PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
22453065-3	2012	Our results demonstrated that the local inflammatory response provoked after 2 h of SpV injection in footpad of mice is characterized by release of pivotal pro-inflammatory mediators (TNF, IL-6 and MCP-1).	spv	84-87	mast cell protease 1	Mus musculus	198-203
22453065-10	2012	Our results demonstrate that SpV evokes a complex inflammatory reaction stimulating a secretion of TNF, IL-6, MCP-1 and leukocytes recruitment at the site of venom injection.	spv	29-32	mast cell protease 1	Mus musculus	110-115
22709825-13	2012	Ethanol pretreatment potentiated poly I:C-induced brain TNFalpha (345%), IL-1beta (331%), IL-6 (255%), and MCP-1(190%).	Ethanol	0-7	mast cell protease 1	Mus musculus	107-112
22709825-13	2012	Ethanol pretreatment potentiated poly I:C-induced brain TNFalpha (345%), IL-1beta (331%), IL-6 (255%), and MCP-1(190%).	Poly I	33-39	mast cell protease 1	Mus musculus	107-112
22709825-13	2012	Ethanol pretreatment potentiated poly I:C-induced brain TNFalpha (345%), IL-1beta (331%), IL-6 (255%), and MCP-1(190%).	Carbon	40-41	mast cell protease 1	Mus musculus	107-112
22387176-7	2012	Incubating BV-2 murine microglial cells with the PPARdelta agonist L-165041 prevented the radiation-induced increase in: (i) intracellular reactive oxygen species generation, (ii) Cox-2 and MCP-1 expression, and (iii) IL-1beta and TNF-alpha message levels.	4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid	67-75	mast cell protease 1	Mus musculus	190-195
22564095-3	2012	Treatment with limonene significantly reduced the levels of IL-5, IL-13, eotaxin, MCP-1, and TGF-beta1 in bronchoalveolar lavage fluid.	Limonene	15-23	mast cell protease 1	Mus musculus	82-87
22558981-1	2012	AIM: To investigate the effect of high glucose and mycophenolate (MMF) on the expression of MCP-1 in human mesangial cells (HMCs) and fibronectin (FN).	Glucose	39-46	mast cell protease 1	Mus musculus	92-97
22558981-1	2012	AIM: To investigate the effect of high glucose and mycophenolate (MMF) on the expression of MCP-1 in human mesangial cells (HMCs) and fibronectin (FN).	Mycophenolic Acid	51-64	mast cell protease 1	Mus musculus	92-97
22558981-7	2012	CONCLUSION: Mycophenolate could inhibit the expressions of MCP-1 and FN in human mesangial cells and it might be expected to delay the development and progression of glomerular sclerosis and interstitial fibrosis.	Mycophenolic Acid	12-25	mast cell protease 1	Mus musculus	59-64
22515414-7	2012	RESULTS: Palmitate (PA) dose-dependently increased lipid accumulation, TG content and induced the secretion of interleukin-1beta (IL-1beta), IL-18, TNF-alpha and MCP-1 from HepG2 cells.	Palmitates	9-18	mast cell protease 1	Mus musculus	162-167
22515414-7	2012	RESULTS: Palmitate (PA) dose-dependently increased lipid accumulation, TG content and induced the secretion of interleukin-1beta (IL-1beta), IL-18, TNF-alpha and MCP-1 from HepG2 cells.	Palmitates	20-22	mast cell protease 1	Mus musculus	162-167
22326488-4	2012	beta-caryophyllene dose-dependently ameliorated cisplatin-induced kidney dysfunction, morphological damage, and renal inflammatory response (chemokines MCP-1 and MIP-2, cytokines TNF-alpha and IL-1beta, adhesion molecule ICAM-1, and neutrophil and macrophage infiltration).	caryophyllene	0-18	mast cell protease 1	Mus musculus	152-157
22155353-2	2012	Both Au and SiAu significantly increased the release of Ca, hydrogen peroxide, NO, IL-1alpha, IL-1beta, IL-6, IL-10, IP-10, MCP-1, MCP-3, TNF-alpha, RANTES, G-CSF, GM-CSF, LIF, MIP-2, VEGF, and PGE2 with enhancing expression of STAT1, STAT3, c-Fos, and COX-2 mRNA in RAW 264.7 cells.	Gold	5-7	mast cell protease 1	Mus musculus	124-129
22570747-4	2012	RESULTS: EGCG inhibited accumulation of LPS-induced IL-12p40, IL-6, MCP-1, ICAM-1, and VCAM-1 mRNA in BMMs.	epigallocatechin gallate	9-13	mast cell protease 1	Mus musculus	68-73
22570747-8	2012	U0126 (an inhibitor of MEK-1/2) suppressed the LPS-induced IL-12p40, IL-6, MCP-1, ICAM-1, and VCAM-1 mRNA accumulation in BMMs.	U 0126	0-5	mast cell protease 1	Mus musculus	75-80
22402625-5	2012	The growth of subcutaneous tumors was markedly suppressed when tumors were treated with mMCP-1, as compared with soluble MCP-1, in combination with the HSV-tk/GCV system (P<0.01).	Ganciclovir	159-162	mast cell protease 1	Mus musculus	88-94
21913218-3	2012	We tested two hypotheses: (1) that exogenous local delivery of MCP-1 induces systematic macrophage recruitment and (2) that blockade of the MCP-1 ligand-receptor axis decreases macrophage recruitment and osteolysis in the presence of ultra high molecular weight polyethylene (UHMWPE) particles.	Polyethylene	262-274	mast cell protease 1	Mus musculus	140-145
21549726-7	2012	Furthermore, we observed an increase in peripheral poly I:C-induced IL-6, TNF-alpha, MCP-1, and MIP-1alpha, but not IL-1beta.	Poly I	51-57	mast cell protease 1	Mus musculus	85-90
21549726-7	2012	Furthermore, we observed an increase in peripheral poly I:C-induced IL-6, TNF-alpha, MCP-1, and MIP-1alpha, but not IL-1beta.	Carbon	58-59	mast cell protease 1	Mus musculus	85-90
22325176-10	2012	mRNA expression levels of the pro-inflammatory cytokines, such as IL-1beta, TNF-alpha, IL-6, IL-12p40, IL-17, and MCP-1 were also suppressed by DHMEQ administration.	dehydroxymethylepoxyquinomicin	144-149	mast cell protease 1	Mus musculus	114-119
21780211-3	2012	DcE inhibited the production of IL-6, IL-8 and MCP-1 in THP-1 cells and the release of IL-6 and MCP-1 in EoL-1 cells after treatment with house dust mite extract.	ethylene dichloride	0-3	mast cell protease 1	Mus musculus	47-52
22212354-6	2012	The CBA analyzing results showed that SK&F 96365 pretreatment efficiently inhibited the production of LPS plus IFN-gamma-induced inflammatory cytokines of IL-6, MCP-1, TNF, INF-gamma, and IL-10.	amicloral	38-44	mast cell protease 1	Mus musculus	165-170
21780211-3	2012	DcE inhibited the production of IL-6, IL-8 and MCP-1 in THP-1 cells and the release of IL-6 and MCP-1 in EoL-1 cells after treatment with house dust mite extract.	ethylene dichloride	0-3	mast cell protease 1	Mus musculus	96-101
21780211-7	2012	The synthesis of IL-5, IL-13, MCP-1 and eotaxin was also decreased in splenocytes of the DcE-treated group, while IFN-gamma was increased in the Dc-administered group.	ethylene dichloride	89-92	mast cell protease 1	Mus musculus	30-35
21871511-9	2011	Clenbuterol and forskolin caused downregulation of cytokines and chemokines such as IL-6 and MCP-1.	Clenbuterol	0-11	mast cell protease 1	Mus musculus	93-98
23028463-12	2012	We demonstrate that Rolipram abrogates SCI-induced PDE4B1 and PDE4A5 production, PDE4A5 phosphorylation, MCP-1 expression and immune cell infiltration, while preventing post-injury reductions in IL-10.	Rolipram	20-28	mast cell protease 1	Mus musculus	105-110
22768141-5	2012	N. sativa seed extract, thymoquinone, and U50"488 also decreased intestinal mast cell numbers and plasma mouse mast cell protease-1 (MMCP-1).	thymoquinone	24-36	mast cell protease 1	Mus musculus	111-131
22768141-5	2012	N. sativa seed extract, thymoquinone, and U50"488 also decreased intestinal mast cell numbers and plasma mouse mast cell protease-1 (MMCP-1).	thymoquinone	24-36	mast cell protease 1	Mus musculus	133-139
22768141-5	2012	N. sativa seed extract, thymoquinone, and U50"488 also decreased intestinal mast cell numbers and plasma mouse mast cell protease-1 (MMCP-1).	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer	42-49	mast cell protease 1	Mus musculus	111-131
22768141-5	2012	N. sativa seed extract, thymoquinone, and U50"488 also decreased intestinal mast cell numbers and plasma mouse mast cell protease-1 (MMCP-1).	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer	42-49	mast cell protease 1	Mus musculus	133-139
21703208-11	2011	Hepatic inflammation was more severe in HF+DSS mice, reflected by histology and analysis of proinflammatory gene expression (TNF and MCP-1).	Dextran Sulfate	43-46	mast cell protease 1	Mus musculus	133-138
22189654-7	2012	Bindarit inhibits the LPS-induced MCP-1 and IL-12beta/p40 expression without affecting other analyzed cytokines.	bindarit	0-8	mast cell protease 1	Mus musculus	34-39
22189654-9	2012	Bindarit showed a specific inhibitory effect on the p65 and p65/p50 induced MCP-1 promoter activation, with no effect on other tested activated promoters.	bindarit	0-8	mast cell protease 1	Mus musculus	76-81
22577255-3	2012	CA strongly suppressed the production of IL-6, IL-8, and MCP-1 from keratinocyte HaCaT cells stimulated with sodium lauryl sulfate (SLS) and retinoic acid (RA).	Sodium Dodecyl Sulfate	109-130	mast cell protease 1	Mus musculus	57-62
22577255-3	2012	CA strongly suppressed the production of IL-6, IL-8, and MCP-1 from keratinocyte HaCaT cells stimulated with sodium lauryl sulfate (SLS) and retinoic acid (RA).	Sodium Dodecyl Sulfate	132-135	mast cell protease 1	Mus musculus	57-62
22577255-3	2012	CA strongly suppressed the production of IL-6, IL-8, and MCP-1 from keratinocyte HaCaT cells stimulated with sodium lauryl sulfate (SLS) and retinoic acid (RA).	Tretinoin	141-154	mast cell protease 1	Mus musculus	57-62
22577255-3	2012	CA strongly suppressed the production of IL-6, IL-8, and MCP-1 from keratinocyte HaCaT cells stimulated with sodium lauryl sulfate (SLS) and retinoic acid (RA).	Tretinoin	156-158	mast cell protease 1	Mus musculus	57-62
22815821-5	2012	We observed that mice receiving both silica and LPS had significantly more total inflammatory cells, more whole lung lavage MCP-1, MIP-2, KC and IL-1beta, more evidence of oxidative stress and more total lung hydroxyproline than mice receiving either LPS alone, or silica alone.	Silicon Dioxide	37-43	mast cell protease 1	Mus musculus	124-129
22761883-6	2012	In cultured tubular epithelial cells (NRK-52E), uric acid, probably transported via urate transporter, induced TNF-alpha, MCP-1 and RANTES mRNA as well as RANTES protein expression.	Uric Acid	48-57	mast cell protease 1	Mus musculus	122-127
21542833-7	2011	In mice with thioglycollate-induced peritonitis, both 5alphaTHB and corticosterone reduced the numbers of neutrophils (58.6%, 49.9%) and inflammatory monocytes (69.5%, 96.4%), and also suppressed MCP-1 (48.7%, 80.9%) and IL-6 (53.5%, 86.7%) in peritoneal exudate.	5alphathb	54-63	mast cell protease 1	Mus musculus	196-201
21542833-7	2011	In mice with thioglycollate-induced peritonitis, both 5alphaTHB and corticosterone reduced the numbers of neutrophils (58.6%, 49.9%) and inflammatory monocytes (69.5%, 96.4%), and also suppressed MCP-1 (48.7%, 80.9%) and IL-6 (53.5%, 86.7%) in peritoneal exudate.	Corticosterone	68-82	mast cell protease 1	Mus musculus	196-201
21767963-11	2011	RESULTS: Finasteride treatment resulted in a reduced posttraumatic cytokine secretion of AM as well as in a decreased concentration of MCP-1 and MIP-1beta in lung tissue.	Finasteride	9-20	mast cell protease 1	Mus musculus	135-140
21871511-9	2011	Clenbuterol and forskolin caused downregulation of cytokines and chemokines such as IL-6 and MCP-1.	Colforsin	16-25	mast cell protease 1	Mus musculus	93-98
21786025-10	2011	Real time analysis showed down regulation of mRNA levels of MMP 2, uPA, PAI, PPAR-A, MCSF1 and up regulation of tPA and MCP-1 in the brain during the progression of cerebral aneurysm and beta carotene supplementation to bring to normal expression levels of all the candidate genes for cerebrovascular diseases.	beta Carotene	187-200	mast cell protease 1	Mus musculus	120-125
21921143-9	2011	In vitro, AMPK activation completely inhibited the induction of MCP-1 by palmitic acid in mesangial cells.	Palmitic Acid	73-86	mast cell protease 1	Mus musculus	64-69
21481872-8	2011	Although serum MCP-1 and MIF concentrations were not changed by either statins, atorvastatin administration increased PPAR-alpha and -gamma mRNA abundances and decreased NF-kappaB p50, p65, MCP-1 and TNF-alpha mRNA abundances in atherosclerotic lesions.	Atorvastatin	80-92	mast cell protease 1	Mus musculus	190-195
21498084-7	2011	WT+STZ mice exhibited significantly increased levels of serum and macrophage IL-1beta, IL-6, KC/IL-8, IP-10, MCP-1, IFN beta and TNF-alpha compared to WT mice and this was significantly attenuated in TLR4(-/-) +STZ mice (P<0.01).	Streptozocin	3-6	mast cell protease 1	Mus musculus	109-114
21825171-4	2011	We found that in the trachea, unlike in skin and intestine, CTMCs and MMCs both express all six serine proteases and CPA3 (mMCP-1(+), -2(+), 4(+)-7(+), CPA3(+)).	ctmcs	60-65	mast cell protease 1	Mus musculus	123-129
21904636-8	2011	At day 7 the pro-inflammatory cytokines MCP-1 and IL-6 were found to be significantly decreased in regional draining lymph nodes of eplerenone-treated mice, whereas the anti-inflammatory cytokine IL-10 was significantly upregulated.	Eplerenone	132-142	mast cell protease 1	Mus musculus	40-45
21808238-10	2011	Furthermore, PPS suppressed NF-kappaB, decreased the proinflammatory actions of TNFalpha, and decreased high glucose and AGEs stimulated MCP-1 production in vitro.	Pentosan Sulfuric Polyester	13-16	mast cell protease 1	Mus musculus	137-142
21808238-10	2011	Furthermore, PPS suppressed NF-kappaB, decreased the proinflammatory actions of TNFalpha, and decreased high glucose and AGEs stimulated MCP-1 production in vitro.	Glucose	109-116	mast cell protease 1	Mus musculus	137-142
22001104-7	2011	RESULTS: Clopidogrel decreased MCP-1 expression in the carotid artery at 4 weeks after irradiation.	Clopidogrel	9-20	mast cell protease 1	Mus musculus	31-36
20371085-11	2011	The mRNA levels of IL-1beta at 6h and MCP-1 at 2 and 6h were markedly higher in the CR group than in the IR group.	Chromium	84-86	mast cell protease 1	Mus musculus	38-43
21183557-12	2011	CGS21680 inhibited the activation of NFkappaB and suppressed the expression of IFN-gamma, MCP-1 and MHC-II in MRL/lpr splenocytes.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	0-8	mast cell protease 1	Mus musculus	90-95
21109611-10	2011	In vitro experiments showed that AIgA-MC medium and recombinant TNF-alpha significantly up-regulated hL-FABP expression, which was partially blocked by anti-TNF-alpha antibody, and major mediators of oxidative stress (HO-1 and 4-HNE) and inflammation (MCP-1).	aiga-mc medium	33-47	mast cell protease 1	Mus musculus	252-257
21317532-8	2011	Furthermore, activation of GPR109A by nicotinic acid inhibited MCP-1-induced recruitment of macrophages into the peritoneal cavity and impaired macrophage recruitment to atherosclerotic plaques.	Niacin	38-52	mast cell protease 1	Mus musculus	63-68
21295043-7	2011	Both flavonoids increased the secretion of an insulin-sensitizing factor, adiponectin, but concomitantly decreased the secretion of an insulin-resistance factor, MCP-1, in 3T3-L1 adipocytes.	Flavonoids	5-15	mast cell protease 1	Mus musculus	162-167
21233289-5	2011	Serum levels of total cholesterol and triglyceride were slightly reduced and those of IL-6, leptin, and MCP-1 were decreased by 40-ppm pitavastatin treatment.	pitavastatin	135-147	mast cell protease 1	Mus musculus	104-109
21233289-6	2011	mRNA expression levels of cyclooxygenase-2, IL-6, inducible nitric oxide (iNOS), MCP-1, and Pai-1 were significantly reduced in intestinal nonpolyp parts by pitavastatin treatment.	pitavastatin	157-169	mast cell protease 1	Mus musculus	81-86
21264946-10	2011	MCP-1 and proMMP-9 exhibit a 3-fold reduction of their relative expressions in Pgf(-/-) injured nerves, as demonstrated by cytokine array.	Prostaglandins F	79-82	mast cell protease 1	Mus musculus	0-5
21099231-8	2011	AoAF-derived MCP-1 was potent in recruiting THP-1 monocytes in vitro, and these monocytes stimulated AoAF proliferation based on a flow cytometric assessment of cell number and (3)H-thymidine incorporation in tissue culture.	Thymidine	182-191	mast cell protease 1	Mus musculus	13-18
21081706-11	2011	Sitagliptin significantly reduced mRNA expression of the following inflammatory cytokines: MCP-1 (3.3-fold), IL-6 (2-fold), IL-12(p40) (2.2-fold), IL-12(p35) (5-fold, P < 0.01), and IP-10 (2-fold).	Sitagliptin Phosphate	0-11	mast cell protease 1	Mus musculus	91-96
21088297-6	2011	ABA suppresses LPS-induced prostaglandin E(2) and MCP-1 production via a PPAR gamma-dependent mechanism possibly involving activation of PPAR gamma and suppression of NF-kappaB and nuclear factor of activated T cells.	Abscisic Acid	0-3	mast cell protease 1	Mus musculus	50-55
21206981-5	2011	When stimulated with poly I:C (and also LPS) JAWSII cells produced large amounts of IL-6, TNF-alpha and MCP-1.	Poly I-C	21-29	mast cell protease 1	Mus musculus	104-109
22146708-5	2011	The adipose tissue mRNA levels of inflammatory adipocytokines (MCP-1 and IL-6) and the liver mRNA levels of genes related to fatty acid synthesis were lower in the coffee and caffeine groups than those in the control group.	Caffeine	175-183	mast cell protease 1	Mus musculus	63-68
21799692-8	2011	Evo and Rut, but not DeHE, also had the ability to inhibit cell migration toward RANTES and MCP-1, respectively.	evodiamine	0-3	mast cell protease 1	Mus musculus	92-97
20606471-7	2011	The IL-17A induced release of the pro-inflammatory cytokines IL-6, G-CSF, GM-CSF and MCP-1 from VSMC, as detected by the Luminex technology, was completely abolished by NAD(P)H-oxidase inhibition.	vsmc	96-100	mast cell protease 1	Mus musculus	85-90
20606471-7	2011	The IL-17A induced release of the pro-inflammatory cytokines IL-6, G-CSF, GM-CSF and MCP-1 from VSMC, as detected by the Luminex technology, was completely abolished by NAD(P)H-oxidase inhibition.	NADP	169-175	mast cell protease 1	Mus musculus	85-90
21071958-6	2011	RESULTS: Correction of renal function in ZDF by pioglitazone, occurring with a glycemia >250 mg/dl, was accompanied by normalization of the renal levels of connective tissue growth factor and fibronectin (fibrosis), TNF-alpha, interleukin-6 and MCP-1 (inflammation), megalin (tubular cells), the PCNA/caspase-3 ratio (positive cell turnover), VEGF (abnormal angiogenesis), and the ratio between eNOS and iNOS (endothelial dysfunction).	Pioglitazone	48-60	mast cell protease 1	Mus musculus	248-253
21909350-10	2011	Finally, quantitative RT-PCR performed to determine the expression patterns of specific inflammatory genes at atherosclerotic aortas revealed lower expression of MCP-1, VCAM-1 and TNF-alpha in the darapladib group.	darapladib	197-207	mast cell protease 1	Mus musculus	162-167
21772662-7	2011	Real time-PCR from thoracic aortas revealed that rivaroxaban (5 mg/kg/day) treatment reduced mRNA expression of inflammatory mediators, such of IL-6, TNF-alpha, MCP-1, and Egr-1 (P < .05).	Rivaroxaban	49-60	mast cell protease 1	Mus musculus	161-166
22086064-9	2011	In mice challenged systemically or intratracheally with LPS, repaglinide significantly decreased serum tumor necrosis factor alpha level and bronchial alveolar lavage fluid MCP-1 levels, respectively.	repaglinide	61-72	mast cell protease 1	Mus musculus	173-178
22003398-7	2011	Immunohistochemical and real-time PCR analyses showed that the expression of MCP-1, TNF-alpha, and MMP-9 in atherosclerotic lesions was significantly decreased in 15d-PGJ2 treated mice.	9-deoxy-delta-9-prostaglandin D2	167-171	mast cell protease 1	Mus musculus	77-82
21865767-4	2011	Systemic treatment with bortezomib was efficacious in the thioglycolate-induced MCP-1 production model, and the dinitrofluorobenzene-induced delayed-type hypersensitivity model.	Bortezomib	24-34	mast cell protease 1	Mus musculus	80-85
21865767-4	2011	Systemic treatment with bortezomib was efficacious in the thioglycolate-induced MCP-1 production model, and the dinitrofluorobenzene-induced delayed-type hypersensitivity model.	Thioglycolates	58-71	mast cell protease 1	Mus musculus	80-85
22110737-3	2011	Here, we report that prophylaxis with inhaled nitric oxide significantly reduced systemic inflammation (lower TNF, IFNgamma and MCP-1 in peripheral blood) and endothelial activation (decreased sICAM-1 and vWF, and increased angiopoeitin-1 levels in peripheral blood) in an experimental cerebral malaria model.	Nitric Oxide	46-58	mast cell protease 1	Mus musculus	128-133
20707612-5	2010	An in vivo study on the 7 day action of TCDD on liver of AhR(NLS) mice showed that several early markers (e.g., Cox-2, MCP-1 and SOCS3) are induced, but not late markers such as IL-1beta.	Polychlorinated Dibenzodioxins	40-44	mast cell protease 1	Mus musculus	119-124
20823099-6	2010	The protective effects of ebselen were associated with a reduction in oxidative stress (hydroperoxides in plasma, 8-isoprostane in urine, nitrotyrosine in the kidney, and 4-hydroxynonenal in the aorta) as well as a reduction in VEGF, CTGF, VCAM-1, MCP-1, and Nox2 after 10 weeks of diabetes in the dKO aorta.	ebselen	26-33	mast cell protease 1	Mus musculus	248-253
20817086-7	2010	Treatment with melatonin decreased the mRNA expression of TNF-alpha, IL-1beta, HO (HO-1 and HO-2), iNOS, MCP1, NFkappaB1, NFkappaB2 and NKAP in old male mice.	Melatonin	15-24	mast cell protease 1	Mus musculus	105-109
21110705-3	2010	We investigated the in vitro effect of cobalt ions on a variety of cell lines by measuring production of the proinflammatory chemokines IL-8 and MCP-1.	Cobalt	39-45	mast cell protease 1	Mus musculus	145-150
21110705-5	2010	RESULTS: We found that cobalt ions enhanced the secretion of IL-8 and MCP-1 in renal epithelial cells, gastric and colon epithelium, monocytes and neutrophils, and small airway epithelial cells but not in alveolar cells.	Cobalt	23-29	mast cell protease 1	Mus musculus	70-75
20851137-12	2010	MCP-1 was found to be significantly produced in all groups in the first hours, except the saline treated mice.	Sodium Chloride	90-96	mast cell protease 1	Mus musculus	0-5
20729388-6	2010	Interestingly, silica-exposed female mice had significantly more inflammatory cells, the majority of which were macrophages, as well as higher levels of the macrophage-specific chemokines MCP-1 and CCL9 in whole lung lavage compared with silica-exposed male mice.	Silicon Dioxide	15-21	mast cell protease 1	Mus musculus	188-193
20684827-9	2010	In addition, aortic expression of proatherogenic molecules including TNF-alpha, IL-1beta, IL-6, MCP-1 and VCAM-1, was lower in the BHB-TZD group than the control group.	3-Hydroxybutyric Acid	131-134	mast cell protease 1	Mus musculus	96-101
20557886-6	2010	Q-real-time PCR and protein array approaches confirmed that TNF-alpha-induced ICAM-1, VCAM-1 and ELAM-1 as well as MCP-1 and IL-6 induction was affected upon 3beta-Adiol pre-incubation.	Androstane-3,17-diol	158-169	mast cell protease 1	Mus musculus	115-120
20684827-9	2010	In addition, aortic expression of proatherogenic molecules including TNF-alpha, IL-1beta, IL-6, MCP-1 and VCAM-1, was lower in the BHB-TZD group than the control group.	tzd	135-138	mast cell protease 1	Mus musculus	96-101
20600768-0	2010	Effects of sodium houttuyfonate on expression of NF-kappaB and MCP-1 in membranous glomerulonephritis.	sodium houttuyfonate	11-31	mast cell protease 1	Mus musculus	63-68
20712904-8	2010	Resveratrol inhibited LPS-induced expression and release of TNF-alpha, IL-6, MCP-1, and iNOS/NO in both cell types with more potency in microglia, and inhibited LPS-induced expression of IL-1beta in microglia but not astrocytes.	Resveratrol	0-11	mast cell protease 1	Mus musculus	77-82
20730378-4	2010	Furthermore, inhibitors of Kv11.1 (DOF, E4031, and astemizole), but not Kv1.3 (margatoxin), suppressed the expression of IL-6 and MCP-1 cytokines by murine resident peritoneal macrophages, while again having no effect on TNF alpha.	dofetilide	35-38	mast cell protease 1	Mus musculus	130-135
20730378-4	2010	Furthermore, inhibitors of Kv11.1 (DOF, E4031, and astemizole), but not Kv1.3 (margatoxin), suppressed the expression of IL-6 and MCP-1 cytokines by murine resident peritoneal macrophages, while again having no effect on TNF alpha.	E 4031	40-45	mast cell protease 1	Mus musculus	130-135
21215233-6	2010	MCP-1 mRNA expression in the injured arteries was increased 7 days after cuff placement and which could be significantly attenuated by nifedipine 5 mgxkg(-1)xd(-1).	Nifedipine	135-145	mast cell protease 1	Mus musculus	0-5
20730378-4	2010	Furthermore, inhibitors of Kv11.1 (DOF, E4031, and astemizole), but not Kv1.3 (margatoxin), suppressed the expression of IL-6 and MCP-1 cytokines by murine resident peritoneal macrophages, while again having no effect on TNF alpha.	Astemizole	51-61	mast cell protease 1	Mus musculus	130-135
21215233-9	2010	CONCLUSION: Our results suggest that high dose nifedipine could suppresses expression of MCP-1 induced by injured arteries via the inhibin NF-kappaB DNA binding activity, thereby attenuating vascular inflammation.	Nifedipine	47-57	mast cell protease 1	Mus musculus	89-94
20730378-6	2010	Using murine P388 cells, which lack endogenous C/EBP Beta expression and are unresponsive to LPS for the expression of both IL-6 and MCP-1, we observed that DOF inhibited LPS-induced expression of IL-6 mRNA following ectopic expression of wild-type C/EBP Beta, but not a serine-64 point mutant.	dofetilide	157-160	mast cell protease 1	Mus musculus	133-138
20544860-4	2010	In Foxp3 mutant mice (Foxp3(sf)), microglia release higher levels of inflammatory cytokines and mediators such as NO, MCP-1, CXCL10, and ROS upon liposaccharide treatment than the wild type, while TNF-alpha and IL-1 beta were not significantly different between wild and mutant microglial cells.	liposaccharide	146-160	mast cell protease 1	Mus musculus	118-123
19913782-4	2010	Reduced serum testosterone level was observed after antigenic stimulation and also altered serum IL-12p70, TNF-alpha, IFN-gamma, MCP-1 or IL-10 level.	Testosterone	14-26	mast cell protease 1	Mus musculus	129-134
20669364-6	2010	In mice with acute peritonitis, leukocyte number and protein concentration in peritoneal exudates peaked with a 16 h lag, and serum levels of MCP-1, IL-6 and TNF-alpha were significantly lower at certain time points in the chloral hydrate-treated group compared to those in the normal saline (NS)-treated control group.	Chloral Hydrate	223-238	mast cell protease 1	Mus musculus	142-147
20650015-6	2010	RESULTS: In both upper and lower airways, subacute CS-exposure induced the expression of GCP-2, MCP-1, MIP-3alpha and resulted in a neutrophilic influx.	Cesium	51-53	mast cell protease 1	Mus musculus	96-101
20564194-7	2010	MCP1 and GRO expression/secretion, and cell migration were completely prevented by the inhibitory PKC-zeta pseudosubstrate and by the nuclear factor-kappa B (NF-kappaB) inhibitor BAY11-7082, but not by wortmannin inhibition of PI3K.	3-(4-methylphenylsulfonyl)-2-propenenitrile	179-189	mast cell protease 1	Mus musculus	0-4
20564194-7	2010	MCP1 and GRO expression/secretion, and cell migration were completely prevented by the inhibitory PKC-zeta pseudosubstrate and by the nuclear factor-kappa B (NF-kappaB) inhibitor BAY11-7082, but not by wortmannin inhibition of PI3K.	Wortmannin	202-212	mast cell protease 1	Mus musculus	0-4
20685261-6	2010	In mice with acute peritonitis, leukocyte number and protein concentration in peritoneal exudates peaked with a 16h lag, and serum levels of MCP-1, IL-6 and TNF-alpha were significantly lower at certain time points in the chloral hydrate-treated group compared to those in the normal saline (NS)-treated control group.	Chloral Hydrate	222-237	mast cell protease 1	Mus musculus	141-146
20730378-8	2010	Taken together, our results implicate a potential role for Kv11.1 in regulating cdk2 and C/EBP Beta activity, where robust transactivation of both IL-6 and MCP-1 transcription is known to be dependent on serine-64 of C/EBP Beta.	Serine	204-210	mast cell protease 1	Mus musculus	156-161
20394810-8	2010	Early secretion of IL-1alpha (80%), RANTES (>800%), MIP-1beta (44%), and MCP-1 (60%) was already detected after 1h of exposure to O(3).	Ozone	133-137	mast cell protease 1	Mus musculus	76-81
19913046-8	2010	The marked increase of proinflammatory cytokines (IL-1beta, IFN-gamma) and chemokines (MCP-1, MIP-2beta, KC) in CCl(4) treated mice was additionally attenuated by ginsan, thereby preventing leukocyte infiltration and local inflammation.	Cefaclor	112-115	mast cell protease 1	Mus musculus	87-92
19931343-7	2010	Examination of cytokine expression levels from lungs of bortezomib treated HRSV-infected mice revealed an increase in G-CSF, IL-6, MCP-1, and RANTES levels and a decrease in total IL-12 compared to mock treated-infected control animals.	Bortezomib	56-66	mast cell protease 1	Mus musculus	131-136
20851384-2	2010	DTH paw swelling, along with the cytokines IL-2, IFNgamma, MCP-1 and TNFalpha, were inhibited in Balb/c mice by cyclosporine A (CsA).	Cyclosporine	112-126	mast cell protease 1	Mus musculus	59-64
20851384-2	2010	DTH paw swelling, along with the cytokines IL-2, IFNgamma, MCP-1 and TNFalpha, were inhibited in Balb/c mice by cyclosporine A (CsA).	Cyclosporine	128-131	mast cell protease 1	Mus musculus	59-64
20385066-6	2010	Our report describes additional biological activities for RANTES, MCP-1, and IL-8, suggesting that these chemokines play a fundamental role in histamine and serotonin generation and cell function in mast cells.	Histamine	143-152	mast cell protease 1	Mus musculus	66-71
20385066-6	2010	Our report describes additional biological activities for RANTES, MCP-1, and IL-8, suggesting that these chemokines play a fundamental role in histamine and serotonin generation and cell function in mast cells.	Serotonin	157-166	mast cell protease 1	Mus musculus	66-71
19553349-4	2009	Following 21 days of treatment, WT DOCA-salt urinary MCP-1 excretion increased from control and was attenuated in the Ephx2-/- DOCA-salt group.	Salts	40-44	mast cell protease 1	Mus musculus	53-58
20388958-9	2009	Administration of indomethacin induced expression of inflammatory chemokines such as KC, MIP1alpha and MCP1, which was suppressed in Bach1-deficient mice.	Indomethacin	18-30	mast cell protease 1	Mus musculus	103-107
19682479-9	2009	Expression of pro-inflammatory chemokine MCP-1 and cytokine IL-6 and markers of oxidative stress, protein-HNE and protein-MDA adducts were markedly increased in lesions of arsenic-exposed mice.	Arsenic	172-179	mast cell protease 1	Mus musculus	41-46
19682479-10	2009	Plasma concentrations of MCP-1, IL-6 and MDA were also significantly elevated in arsenic-exposed mice.	Arsenic	81-88	mast cell protease 1	Mus musculus	25-30
19586617-8	2009	Moreover, atorvastatin partially prevented arterial wall thickening, TGF-beta pathway activation, MCP-1 induction and smooth muscle cell proliferation induced by L-NAME treatment although blood pressure was only slightly reduced, suggesting mechanisms independent of blood pressure levels.	Atorvastatin	10-22	mast cell protease 1	Mus musculus	98-103
19553349-4	2009	Following 21 days of treatment, WT DOCA-salt urinary MCP-1 excretion increased from control and was attenuated in the Ephx2-/- DOCA-salt group.	Desoxycorticosterone Acetate	35-39	mast cell protease 1	Mus musculus	53-58
19553349-4	2009	Following 21 days of treatment, WT DOCA-salt urinary MCP-1 excretion increased from control and was attenuated in the Ephx2-/- DOCA-salt group.	Desoxycorticosterone Acetate	127-131	mast cell protease 1	Mus musculus	53-58
19553349-4	2009	Following 21 days of treatment, WT DOCA-salt urinary MCP-1 excretion increased from control and was attenuated in the Ephx2-/- DOCA-salt group.	Salts	132-136	mast cell protease 1	Mus musculus	53-58
19950590-8	2009	In vitro and in vivo chemotaxis assays were performed to determine the effect of AS605240 on MCP-1-induced macrophage chemotaxis.	5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione	81-89	mast cell protease 1	Mus musculus	93-98
19950590-12	2009	In vitro and in vivo chemotaxis assays indicated that AS605240 significantly suppressed MCP-1-induced macrophage chemotaxis (P<0.01).	5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione	54-62	mast cell protease 1	Mus musculus	88-93
19215923-0	2009	Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells.	Phosphatidylcholines	4-23	mast cell protease 1	Mus musculus	48-53
19277846-0	2009	Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells.	sulforaphane	0-12	mast cell protease 1	Mus musculus	84-89
19277846-3	2009	RESULTS: One-hour pretreatment of endothelial cells (EC) with sulforaphane (1-4 muM) suppressed TNF-alpha-induced MCP-1 and VCAM-1 mRNA and protein levels, but had no effect on TNF-alpha-induced ICAM-1 expression.	sulforaphane	62-74	mast cell protease 1	Mus musculus	114-119
19136706-10	2009	Intraocular mRNA expression of ICAM-1 and MCP-1 was downregulated, and the retinal adherent leukocyte counts were significantly decreased in telmisartan-treated mice compared with vehicle-treated mice.	Telmisartan	141-152	mast cell protease 1	Mus musculus	42-47
19454717-3	2009	We found that, in renal tubular cells, induction of MCP-1 by inflammatory cytokines was blunted by CsA and FK506.	Cyclosporine	99-102	mast cell protease 1	Mus musculus	52-57
19454717-3	2009	We found that, in renal tubular cells, induction of MCP-1 by inflammatory cytokines was blunted by CsA and FK506.	Tacrolimus	107-112	mast cell protease 1	Mus musculus	52-57
19454717-7	2009	In TNF-alpha-treated cells, suppression of MCP-1 by CsA or FK506 was associated with blunted responses of NF-kappaB, the crucial regulator of MCP-1.	Cyclosporine	52-55	mast cell protease 1	Mus musculus	43-48
19454717-7	2009	In TNF-alpha-treated cells, suppression of MCP-1 by CsA or FK506 was associated with blunted responses of NF-kappaB, the crucial regulator of MCP-1.	Cyclosporine	52-55	mast cell protease 1	Mus musculus	142-147
19454717-7	2009	In TNF-alpha-treated cells, suppression of MCP-1 by CsA or FK506 was associated with blunted responses of NF-kappaB, the crucial regulator of MCP-1.	Tacrolimus	59-64	mast cell protease 1	Mus musculus	43-48
19454717-10	2009	Furthermore, down-regulation of C/EBPbeta by small interfering RNA substantially reversed the suppressive effect of CsA on TNF-alpha-induced MCP-1 expression.	Cyclosporine	116-119	mast cell protease 1	Mus musculus	141-146
18842266-6	2009	MCP-1 mRNA levels and secretion were 37% (P<0.05) and 38% (P<0.05) lower, respectively, in elicited peritoneal Mphi isolated from HSF R=1:1 compared to HSF omega-6 fed mice.	omega-6	162-169	mast cell protease 1	Mus musculus	0-5
19168128-3	2009	We found that Licochalcone A remarkably inhibited LPS-induced NO production, and TNFalpha expression and MCP-1 expression in both RAW264.7 cells and primary macrophages.	licochalcone	14-26	mast cell protease 1	Mus musculus	105-110
19168128-4	2009	Furthermore, when injected with Licochalcone A prior to injection of LPS, the serum level of TNFalpha and MCP-1 in C57BL/6 mice was clearly decreased, indicating that Licochalcone A has a potent anti-inflammatory effect both in vitro and in vivo.	licochalcone	32-44	mast cell protease 1	Mus musculus	106-111
19168128-4	2009	Furthermore, when injected with Licochalcone A prior to injection of LPS, the serum level of TNFalpha and MCP-1 in C57BL/6 mice was clearly decreased, indicating that Licochalcone A has a potent anti-inflammatory effect both in vitro and in vivo.	licochalcone A	32-46	mast cell protease 1	Mus musculus	106-111
19159432-7	2009	Transmigration of TB-PF NK cells was significantly high in response to IL-8, IP-10, MCP-1 and SLC.	tb-pf	18-23	mast cell protease 1	Mus musculus	84-89
19159945-10	2009	We speculate that the accumulation of DHA in tubules might stimulate epithelium to produce MCP-1 and that profibrogenic TGF-beta produced by infiltrated macrophages might stimulate interstitial fibroblasts to produce collagen.	2,8-dihydroxyadenine	38-41	mast cell protease 1	Mus musculus	91-96
19174150-5	2009	We found that 1,5-AF pretreatment attenuated cytokine release into the serum, including TNF-alpha, IL-6 and macrophage chemoattractant protein (MCP)-1.	1,5-anhydrofructose	14-20	mast cell protease 1	Mus musculus	108-150
19234608-11	2009	IL-6, TNFalpha, and MCP-1 mRNA expression were increased in the colon of TLE-fed, DSS-exposed NF-kappaB(EGFP) mice compared to the control diet.	(5r)-3-Ethyl-4-Hydroxy-5-Methyl-5-[(1e)-2-Methylbuta-1,3-Dien-1-Yl]thiophen-2(5h)-One	73-76	mast cell protease 1	Mus musculus	20-25
19133137-16	2009	Levels of cytokine mRNA were affected similarly, suggesting that TMP is acting to prevent gene expression.TMP partially blocked the production of TNF-alpha and MCP-1 in vivo in the serum of C57BL6/J mice that were challenged i.p.	terameprocol	106-109	mast cell protease 1	Mus musculus	160-165
19144079-5	2009	However, in contrast to LL-pTREX, LL-pTmIL10 inhibited the LPS-stimulated secretion of MCP-1 by BM-DC and reduced the synergistic up-regulation of IL-12/IL-23p40.	ll-ptmil10	34-44	mast cell protease 1	Mus musculus	87-92
18854367-10	2009	Lower molecular weight hyaluronan induced IL-6 and MCP-1 production in PBMC, but high-molecular-weight hyaluronan did not induce IL-6 and MCP-1 production.	Hyaluronic Acid	23-33	mast cell protease 1	Mus musculus	51-56
18854367-11	2009	An anti-CD44 antibody attenuated the induction of both IL-6 and MCP-1 in lower molecular weight hyaluronan-stimulated PBMC.	Hyaluronic Acid	96-106	mast cell protease 1	Mus musculus	64-69
19234608-11	2009	IL-6, TNFalpha, and MCP-1 mRNA expression were increased in the colon of TLE-fed, DSS-exposed NF-kappaB(EGFP) mice compared to the control diet.	Dextran Sulfate	82-85	mast cell protease 1	Mus musculus	20-25
18948087-7	2008	Following TBI, the spared cortex of the rosiglitazone group showed significantly less numbers of GSI-B4(+) activated microglia/macrophages and ICAM1(+) capillaries, and curtailed induction of pro-inflammatory genes IL6, MCP1 and ICAM1 compared to vehicle group.	Rosiglitazone	40-53	mast cell protease 1	Mus musculus	220-224
19305493-5	2009	The ability of phagocytosis and superoxide release by AM was reduced by MCP-1 neutralizing antibodies.	Superoxides	32-42	mast cell protease 1	Mus musculus	72-77
19305493-7	2009	AM from MCP-1(-/-) mice also demonstrated less superoxide and impaired phagocytosis over the controls.	Superoxides	47-57	mast cell protease 1	Mus musculus	8-13
18838678-5	2008	STZ-treated diabetic DBA/2J mice developed progressive albuminuria and glomerulosclerosis within 13 weeks, accompanied by increased intrarenal production of angiotensin (Ang) II, fibronection, TGF-beta, and MCP-1 and decreased expression of slit diaphragm proteins.	Streptozocin	0-3	mast cell protease 1	Mus musculus	207-212
18599682-3	2008	JNJ-27141491 strongly suppressed hCCR2-mediated in vitro functions, such as MCP-1-induced guanosine 5"-O-(3-[(35)S]thio)triphosphate binding; MCP-1, -3, and -4-induced Ca(2+) mobilization; and leukocyte chemotaxis toward MCP-1 (IC(50) = 7-97 nM), whereas it had little or no effect on the function of other chemokine receptors tested.	Guanosine	90-99	mast cell protease 1	Mus musculus	76-81
18829859-12	2008	The expression of VEGF, MCP-1, IL-6, and ICAM-1 was significantly inhibited in telmisartan-treated mice.	Telmisartan	79-90	mast cell protease 1	Mus musculus	24-29
18845708-10	2008	For example, rosiglitazone induced inflammatory genes (e.g., MCP-1) only during zinc deficiency, and adequate zinc was required for rosiglitazone to down-regulate pro-inflammatory markers such as iNOS.	Rosiglitazone	13-26	mast cell protease 1	Mus musculus	61-66
18599682-3	2008	JNJ-27141491 strongly suppressed hCCR2-mediated in vitro functions, such as MCP-1-induced guanosine 5"-O-(3-[(35)S]thio)triphosphate binding; MCP-1, -3, and -4-induced Ca(2+) mobilization; and leukocyte chemotaxis toward MCP-1 (IC(50) = 7-97 nM), whereas it had little or no effect on the function of other chemokine receptors tested.	thio)triphosphate	115-132	mast cell protease 1	Mus musculus	76-81
18552204-6	2008	Supernatants from PAMP + ATP-treated glia induced the secretion of IL-6, IL-13, and MCP-1 from the MC/9 mast cell line in a manner similar to exogenous recombinant IL-33.	Adenosine Triphosphate	25-28	mast cell protease 1	Mus musculus	84-89
18706086-11	2008	In contrast, these MCP-1-/- mice showed significantly lower inductions of brain pro-inflammatory cytokines and chemokines, fewer activated microglia, and a reduction in serum corticosterone levels.	Corticosterone	175-189	mast cell protease 1	Mus musculus	19-24
18463324-9	2008	CsA-induced increases in macrophage infiltration and expression of MCP-1 and ICAM-1 after CsA treatment were significantly reduced by COMP-Ang1.	Cyclosporine	0-3	mast cell protease 1	Mus musculus	67-72
18463324-9	2008	CsA-induced increases in macrophage infiltration and expression of MCP-1 and ICAM-1 after CsA treatment were significantly reduced by COMP-Ang1.	Cyclosporine	90-93	mast cell protease 1	Mus musculus	67-72
18467446-8	2008	In addition, the nitroalkene-mediated inhibitory effects on STAT1 phosphorylation, iNOS expression, and MCP-1 secretion were also largely attenuated by the MKP-1 small interfering RNA approach.	nitroalkene	17-28	mast cell protease 1	Mus musculus	104-109
18093596-9	2008	Thus, we have shown that rosiglitazone appears to have direct anti-atherosclerotic effects in an animal model of diabetes-associated atherosclerosis which are at least partly due to effects on VCAM-1, ICAM-1, MCP-1 and P-selectin expression which leads to decreased leukocyte adhesion and macrophage infiltration.	Rosiglitazone	25-38	mast cell protease 1	Mus musculus	209-214
18334542-5	2008	Animals fed the high-cholesterol/cholate diet for 3 weeks developed a significant, predominantly mononuclear leukocyte infiltration in the liver, hepatic steatosis, elevated hepatic expression of MCP-1, RANTES, and MIP-2, and increased serum levels of liver enzymes.	Cholates	33-40	mast cell protease 1	Mus musculus	196-201
18323514-4	2008	METHODS AND RESULTS: Pravastatin or pitavastatin treatment of obese mice attenuated an increase in mRNA expressions of proinflammatory genes, including MCP1 and IL6, in adipose tissue.	Pravastatin	21-32	mast cell protease 1	Mus musculus	152-156
18334542-5	2008	Animals fed the high-cholesterol/cholate diet for 3 weeks developed a significant, predominantly mononuclear leukocyte infiltration in the liver, hepatic steatosis, elevated hepatic expression of MCP-1, RANTES, and MIP-2, and increased serum levels of liver enzymes.	Cholesterol	21-32	mast cell protease 1	Mus musculus	196-201
18323514-4	2008	METHODS AND RESULTS: Pravastatin or pitavastatin treatment of obese mice attenuated an increase in mRNA expressions of proinflammatory genes, including MCP1 and IL6, in adipose tissue.	pitavastatin	36-48	mast cell protease 1	Mus musculus	152-156
17765904-9	2008	Pretreatment with EPA attenuated the up-regulation of VCAM-1, ICAM-1 and MCP-1 in HUVECs as well as the expression of MMP-2 and MMP-9 in macrophage-like cells induced by TNF-alpha.	Eicosapentaenoic Acid	18-21	mast cell protease 1	Mus musculus	73-78
18313755-9	2008	In positions P3 and P4, N-terminal of the cleaved bond, mMCP-1 showed specificity for aliphatic amino acids.	aliphatic amino acids	86-107	mast cell protease 1	Mus musculus	56-62
18062932-2	2008	Earlier we reported that avenanthramide (Avn)s-enriched extract of oats (AvnsO) significantly suppressed interleukin (IL)-1beta-stimulated secretion of proinflammatory cytokines, such as IL-6, IL-8, and MCP-1, by human aortic endothelial cells (HAEC).	avenanthramide-2C	25-39	mast cell protease 1	Mus musculus	203-208
18348728-9	2008	Ten daily doses of ethanol increased brain and liver TNFalpha, and pretreatment with ethanol potentiated LPS-induced increases in TNFalpha, MCP-1, IL-1beta in liver, serum and brain.	Ethanol	85-92	mast cell protease 1	Mus musculus	140-145
18062932-2	2008	Earlier we reported that avenanthramide (Avn)s-enriched extract of oats (AvnsO) significantly suppressed interleukin (IL)-1beta-stimulated secretion of proinflammatory cytokines, such as IL-6, IL-8, and MCP-1, by human aortic endothelial cells (HAEC).	AVN	41-44	mast cell protease 1	Mus musculus	203-208
18062932-5	2008	CH3-Avn-c, a synthetically prepared methyl ester derivative of Avn-c with a high biological potency, significantly and dose dependently decreased mRNA expression and secretion of IL-6, IL-8, and MCP-1 by HAEC as determined by real-time RT-PCR and ELISA, and it inhibited IL-1beta- and TNFalpha-stimulated NF-kappaB activation as determined by a NF-kappaB DNA binding assay and a NF-kappaB luciferase reporter assay.	methyl ester	36-48	mast cell protease 1	Mus musculus	195-200
17537731-5	2007	The mutation of IKKalpha putative nuclear localization sequence, which prevents its nuclear translocation, or of crucial serines in the IKKalpha activation loop completely inhibits p65 binding on icam-1 and mcp-1 promoters and rather enhances p65 binding on the ikappabalpha promoter.	Serine	121-128	mast cell protease 1	Mus musculus	207-212
18001740-3	2008	This mouse mast cell protease-1 sensitive, calcium-independent PLA2 is not detectable in the jejunal epithelium of uninfected mice but becomes highly expressed within the epithelial compartment within days of nematode establishment.	Calcium	43-50	mast cell protease 1	Mus musculus	11-31
17947701-5	2007	We found that dextran sulfate sodium induced production of proinflammatory cytokines (IL-12 and TNF-alpha) and chemokines (KC, MIP-1alpha, MIP-2, and MCP-1) by DCs.	Dextran Sulfate	14-36	mast cell protease 1	Mus musculus	150-155
17891746-8	2007	The specific c-Jun N-terminal kinase (JNK) inhibitor SP600125 abolished c-Jun phosphorylation at all time points and blunted TGF-beta- or BSA-induced procollagen-1alpha 1 and MCP-1 gene expression in HK-2 cells.	pyrazolanthrone	53-61	mast cell protease 1	Mus musculus	175-180
17719033-3	2007	Capsaicin inhibited the expressions of IL-6 and MCP-1 mRNAs and protein release from the adipose tissues and adipocytes of obese mice, whereas it enhanced the expression of the adiponectin gene and protein.	Capsaicin	0-9	mast cell protease 1	Mus musculus	48-53
17849370-7	2007	We here report, for the first time, that the prosthetic material surface (non-phagocytable) of as-cast high carbon CoCrMo reduces the pro-inflammatory cytokine IL-6 transcription, the chemokine MCP-1 secretion, and M-CSF secretion by 77%, 36%, and 62%, respectively.	Carbon	108-114	mast cell protease 1	Mus musculus	194-199
17565047-8	2007	SR140333 injected 30 min before or 1 h after CLP significantly attenuated the increased lung MPO activity and levels of MIP-2, MCP-1, IL-1beta, IL-6, ICAM-1, and E- and P-selectin compared with CLP-operated mice injected with the vehicle.	SR 140333	0-8	mast cell protease 1	Mus musculus	127-132
17641061-4	2007	Activation of neutrophils with LPS, lipoteichoic acid, or N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-[R]-Cys-[S]-Ser-[S]-Lys did not induce significant MCP-1 production and release; however, the Th1 cytokine IFN-gamma dramatically up-regulated MCP-1 production in cells activated with each TLR ligand.	r]-cys	110-116	mast cell protease 1	Mus musculus	160-165
17641061-4	2007	Activation of neutrophils with LPS, lipoteichoic acid, or N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-[R]-Cys-[S]-Ser-[S]-Lys did not induce significant MCP-1 production and release; however, the Th1 cytokine IFN-gamma dramatically up-regulated MCP-1 production in cells activated with each TLR ligand.	r]-cys	110-116	mast cell protease 1	Mus musculus	252-257
17537724-8	2007	The reduction in caerulein-induced pancreatic inflammation is dependent upon Tpl2 ablation in non-myeloid cells and is associated with both in vivo and in vitro inhibition of MEK, JNK, and AP-1 activation and the expression of MCP-1, MIP-2, and interleukin-6.	Ceruletide	17-26	mast cell protease 1	Mus musculus	227-232
17442725-6	2007	Finally, gentamicin"s potential impact(s) on TNF-alpha/MCP-1 mRNA levels in nontraditional "target" organs (liver, spleen) was assessed.	Gentamicins	9-19	mast cell protease 1	Mus musculus	55-60
17442725-11	2007	Gentamicin augmented LPS-driven renal mRNA increases (TNF-alpha, MCP-1, IL-10, iNOS).	Gentamicins	0-10	mast cell protease 1	Mus musculus	65-70
17442725-7	2007	Gentamicin, when administered alone, slightly increased renal cortical TNF-alpha and MCP-1 mRNAs, but without changing plasma or renal TNF-alpha/MCP-1 protein levels.	Gentamicins	0-10	mast cell protease 1	Mus musculus	85-90
17451938-5	2007	The cytokines KC and MCP-1 were observed to increase after CA4P treatment in all tested models.	CA4P	59-63	mast cell protease 1	Mus musculus	21-26
17494092-8	2007	Urinary IL-6, MCP-1, KC, and GM-CSF also showed a synergistic increase with cisplatin+LPS treatment.	Cisplatin	76-85	mast cell protease 1	Mus musculus	14-19
17697525-4	2007	Telmisartan, an Ang II type 1 receptor blocker, downregulated RAGE mRNA and inhibited superoxide generation and MCP-1 gene expression in mesangial cells; these processes were blocked by GW9662, a PPAR-gamma inhibitor.	Telmisartan	0-11	mast cell protease 1	Mus musculus	112-117
17697525-4	2007	Telmisartan, an Ang II type 1 receptor blocker, downregulated RAGE mRNA and inhibited superoxide generation and MCP-1 gene expression in mesangial cells; these processes were blocked by GW9662, a PPAR-gamma inhibitor.	2-chloro-5-nitrobenzanilide	186-192	mast cell protease 1	Mus musculus	112-117
17697525-6	2007	Telmisartan and the antioxidant, N-acetylcysteine, completely inhibited AGEs-induced MCP-1 overproduction by mesangial cells.	Telmisartan	0-11	mast cell protease 1	Mus musculus	85-90
17697525-6	2007	Telmisartan and the antioxidant, N-acetylcysteine, completely inhibited AGEs-induced MCP-1 overproduction by mesangial cells.	Acetylcysteine	33-49	mast cell protease 1	Mus musculus	85-90
17697525-7	2007	These results suggest that telmisartan inhibits AGEs-signalling to MCP-1 expression in mesangial cells by downregulating RAGE gene expression and subsequent oxidative stress generation via PPAR-gamma activation.	Telmisartan	27-38	mast cell protease 1	Mus musculus	67-72
17459878-3	2007	Our previous studies have shown that the CD40-CD40L interaction modulates release of reactive oxygen species (ROS) and the current findings demonstrate that in endothelial cells CD40L dose dependently induces intracellular CD40L and MCP1 release in a redox sensitive manner.	Reactive Oxygen Species	85-108	mast cell protease 1	Mus musculus	233-237
17459878-3	2007	Our previous studies have shown that the CD40-CD40L interaction modulates release of reactive oxygen species (ROS) and the current findings demonstrate that in endothelial cells CD40L dose dependently induces intracellular CD40L and MCP1 release in a redox sensitive manner.	Reactive Oxygen Species	110-113	mast cell protease 1	Mus musculus	233-237
17453481-6	2007	The aim of this investigation was to reveal whether TAMs in HNSCCs secrete IL-6 and MCP-1.	tams	52-56	mast cell protease 1	Mus musculus	84-89
17147981-0	2007	SKL-2841, a dual antagonist of MCP-1 and MIP-1 beta, prevents bleomycin-induced skin sclerosis in mice.	skl-2841	0-8	mast cell protease 1	Mus musculus	31-36
17147981-0	2007	SKL-2841, a dual antagonist of MCP-1 and MIP-1 beta, prevents bleomycin-induced skin sclerosis in mice.	Bleomycin	62-71	mast cell protease 1	Mus musculus	31-36
17147981-3	2007	SKL-2841 was initially synthesized as a novel small molecule antagonist of MCP-1.	skl-2841	0-8	mast cell protease 1	Mus musculus	75-80
17147981-5	2007	In the early stages of bleomycin-induced skin lesions, immunohistochemical analysis showed the expression of both MCP-1 and MIP-1 beta in dermal inflammatory cells.	Bleomycin	23-32	mast cell protease 1	Mus musculus	114-119
16888236-5	2006	AT1-R signaling blockade with telmisartan inhibited various inflammatory mechanisms including macrophage infiltration and upregulation of VEGF, intercellular adhesion molecule-1 (ICAM-1), MCP-1, and IL-6 in the retinal pigment epithelium-choroid complex.	Telmisartan	30-41	mast cell protease 1	Mus musculus	188-193
17272747-4	2007	Furthermore, we report that BH4 treatment improves endothelial dysfunction and attenuates increased mRNA expression of NADPH oxidase components, as well as a number of inflammatory factors, such as LOX-1 and MCP-1, in the aortas of apolipoprotein E- knockout mice.	sapropterin	28-31	mast cell protease 1	Mus musculus	208-213
17095756-8	2007	IL-1beta, CCR2, MCP-1, and inducible nitric oxide synthase mRNA levels in colons of PPAR-gamma(DeltaMphi) mice treated with DSS were higher than in similarly treated PPAR-gamma(F/F) mice.	Dextran Sulfate	124-127	mast cell protease 1	Mus musculus	16-21
17433708-0	2007	C/EBPbeta serine 64, a phosphoacceptor site, has a critical role in LPS-induced IL-6 and MCP-1 transcription.	Serine	10-16	mast cell protease 1	Mus musculus	89-94
17433708-7	2007	Thus, serine 64, probably through its phosphorylation, is a critical determinant of C/EBPbeta activity in the transcription of IL-6 and MCP-1.	Serine	6-12	mast cell protease 1	Mus musculus	136-141
17014850-4	2007	Several fold increases of IFN-gamma, TNF-alpha, MCP-1, and IL-6 cytokines were detected after estradiol-treatment of mice, resulting in greatly enhanced inflammation and tissue damage throughout the reproductive tract.	Estradiol	94-103	mast cell protease 1	Mus musculus	48-53
17237430-4	2007	Asbestos also caused increases in IL-4, MIP-1beta, and MCP-1 in BALF that were more elevated (p < or = 0.05) in Tg(+) mice at 9 days.	Asbestos	0-8	mast cell protease 1	Mus musculus	55-60
17090620-10	2007	DON markedly enhanced viral-induced elevations of protein, MCP-1, TNF-alpha, and inflammatory cells in the BALF at 3-day PI.	deoxynivalenol	0-3	mast cell protease 1	Mus musculus	59-64
17202330-5	2007	The PGI(2) analogs decreased BMDC production of proinflammatory cytokines (IL-12, TNF-alpha, IL-1alpha, IL-6) and chemokines (MIP-1alpha, MCP-1) and increased the production of the anti-inflammatory cytokine IL-10 by BMDCs.	Epoprostenol	4-10	mast cell protease 1	Mus musculus	138-143
17202330-5	2007	The PGI(2) analogs decreased BMDC production of proinflammatory cytokines (IL-12, TNF-alpha, IL-1alpha, IL-6) and chemokines (MIP-1alpha, MCP-1) and increased the production of the anti-inflammatory cytokine IL-10 by BMDCs.	bmdc	29-33	mast cell protease 1	Mus musculus	138-143
17174561-2	2006	Inhibition of AR by three distinct AR inhibitors sorbinil, tolrestat or zopolrestat suppressed the LPS-induced production of inflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, IFN-gamma, and chemokine MCP-1 in murine peritoneal macrophages.	zopolrestat	72-83	mast cell protease 1	Mus musculus	208-213
17823504-10	2007	In addition, AG490 inhibited the expression of MCP-1 mRNA, accompanied by reduced interstitial infiltration of macrophages and T cells (p <0.05).	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	13-18	mast cell protease 1	Mus musculus	47-52
16873727-6	2006	This additional effect in HC+FF was paralleled by an extra reduction of aortic inflammation (macrophage content; monocyte adhesion; intercellular adhesion molecule-1 [ICAM-1], soluble vascular cell adhesion molecule-1, granulocyte-macrophage colony-stimulating factor (GM-CSF), MCP-1, and NF-kappaB expression), systemic inflammation (plasma SAA and fibrinogen levels), and by an upregulation of plasma apoE levels.	hc+ff	26-31	mast cell protease 1	Mus musculus	278-283
16888236-6	2006	A PPAR-gamma antagonist partially but significantly reversed the suppressive effect of telmisartan on in vivo induction of CNV and in vitro upregulation of ICAM-1 and MCP-1 in endothelial cells and IL-6 in macrophages, showing the dual contribution of PPAR-gamma-agonistic and AT1-R-antagonistic actions in the telmisartan treatment.	Telmisartan	87-98	mast cell protease 1	Mus musculus	167-172
17136324-9	2006	CONCLUSION: These Results suggest that down-regulation of MCP-1 is the main mechanism for antiatherogenic activity of triterpenes and MCP-1 might play important roles in the development of atherosclerosis and xanthoma.	Triterpenes	118-129	mast cell protease 1	Mus musculus	58-63
16764943-8	2006	Interestingly, a combination of 9-cis RA and the PPAR-alpha agonists fenofibrate or gemfibrozil cooperatively inhibited NO, TNF-alpha, IL-1beta, IL-6, and MCP-1 production by these cells.	Radium	38-40	mast cell protease 1	Mus musculus	155-160
16741149-4	2006	METHODS AND RESULTS: In vascular smooth muscle cells (VSMCs) and monocytes stimulated with lipopolysaccharide (LPS), nontoxic doses of PTN reduced IkappaBalpha degradation, NF-kappaB activation, and MCP-1 expression, without inhibiting AP-1 and MAPK.	parthenolide	135-138	mast cell protease 1	Mus musculus	199-204
16895975-5	2006	Administration of E2, flutamide, or E2 + flutamide following T-H resulted in a significant decrease in systemic TNF-alpha, IL-6, and MCP-1 concentrations under those conditions.	Flutamide	22-31	mast cell protease 1	Mus musculus	133-138
16895975-5	2006	Administration of E2, flutamide, or E2 + flutamide following T-H resulted in a significant decrease in systemic TNF-alpha, IL-6, and MCP-1 concentrations under those conditions.	Flutamide	41-50	mast cell protease 1	Mus musculus	133-138
16751070-9	2006	In L-929 cells, EsA inhibited VEGF, TNF, and MCP-1 production at 2, 4, and 8 Gy.	esculentoside A	16-19	mast cell protease 1	Mus musculus	45-50
16764943-8	2006	Interestingly, a combination of 9-cis RA and the PPAR-alpha agonists fenofibrate or gemfibrozil cooperatively inhibited NO, TNF-alpha, IL-1beta, IL-6, and MCP-1 production by these cells.	Fenofibrate	69-80	mast cell protease 1	Mus musculus	155-160
16764943-8	2006	Interestingly, a combination of 9-cis RA and the PPAR-alpha agonists fenofibrate or gemfibrozil cooperatively inhibited NO, TNF-alpha, IL-1beta, IL-6, and MCP-1 production by these cells.	Gemfibrozil	84-95	mast cell protease 1	Mus musculus	155-160
15698514-5	2005	Here we found, that MCP-1 was partially inhibited by L-mimosine, while MIP-2 was totally inhibited.	Mimosine	53-63	mast cell protease 1	Mus musculus	20-25
16709811-4	2006	Similarly, administration of alphaCD40 to both wild-type and CD40-/- mice bearing Renca tumors resulted in substantial amounts of TNF-alpha and MCP-1 in the serum, increased the number of total splenocytes and MHC class II+ CD11c+ leukocytes, and when combined with IFN-gamma, inhibited the progression of established Renca tumors in vivo in both wild-type and CD40-/- mice.	alphacd40	29-38	mast cell protease 1	Mus musculus	144-149
16303184-5	2006	However, this retinoid had no effect on IL-6 secretion and increased MCP-1 production by LPS-stimulated microglia.	Retinoids	14-22	mast cell protease 1	Mus musculus	69-74
15748950-3	2005	The results show that TZDs and 15d-PGJ(2) are effective in inhibiting production of nitric oxide, the pro-inflammatory cytokines TNF-alpha, IL-1beta, and IL-6, and the chemokine MCP-1 from microglia and astrocytes.	Thiazolidinediones	22-26	mast cell protease 1	Mus musculus	178-183
15748950-3	2005	The results show that TZDs and 15d-PGJ(2) are effective in inhibiting production of nitric oxide, the pro-inflammatory cytokines TNF-alpha, IL-1beta, and IL-6, and the chemokine MCP-1 from microglia and astrocytes.	15d-pgj	31-38	mast cell protease 1	Mus musculus	178-183
15681167-5	2005	Deoxynivalenol was found to readily induce expression of cytokines (IL-1alpha, IL-1beta, and IL-6 and IL-11), chemokines (MCP-1, MCP-3, CINC-1 and MIP-2), components of the activator protein-1 (AP-1) transcription factor complex (c-Fos, Fra-2, c-Jun and JunB), as well as two hydrolases (MKP1, CnAbeta).	deoxynivalenol	0-14	mast cell protease 1	Mus musculus	122-127
16581975-4	2006	MPTP-induced expression of microglia-derived factors, TNF-alpha, MCP-1, and IL-1alpha, preceded the degeneration of striatal dopaminergic nerve terminals and astrogliosis, as assessed by loss of striatal dopamine and TH, and an increase in striatal GFAP.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	0-4	mast cell protease 1	Mus musculus	65-70
16332510-5	2006	In the present study, the combined effects of nicotine and bacterial LPS on the expression of IL-6, IL-8, GRO-alpha and MCP-1 in cell lines of human coronary artery endothelial cells (HCAEC) and pulmonary monocytes (THP-1) were examined by quantitative real-time PCR and ELISA.	Nicotine	46-54	mast cell protease 1	Mus musculus	120-125
15698514-7	2005	These findings show, that L-mimosine may have an inhibitory effect on MCP-1 and MIP-2 serum levels in Trichinellosis and may influence the recruitment of inflammatory cells and the intensity of the inflammatory reaction in this parasitic disease.	Mimosine	26-36	mast cell protease 1	Mus musculus	70-75
15316134-3	2004	Following sensitization and inhalation exposure to ovalbumin, the bronchoalveolar lavage fluid of mice in the cholesterol group contained higher numbers of eosinophils and elevated levels of IL-5, PGE(2), and MCP-1.	Cholesterol	110-121	mast cell protease 1	Mus musculus	209-214
15681167-6	2005	Expression of these genes was transient, peaking within 2-4 h and declining thereafter, with the single exception being IL-11 that was elevated at 8 h. (n-3)-PUFA consumption significantly suppressed DON-induced expression of IL-1alpha, IL-6, IL-11, MCP-1, MCP-3, MIP-2 and Fra-2 at 8 h. In contrast, mice fed (n-3)-PUFA exhibited significant increases in MKP1 and CnAbeta expression.	Fatty Acids, Unsaturated	158-162	mast cell protease 1	Mus musculus	250-255
15681167-6	2005	Expression of these genes was transient, peaking within 2-4 h and declining thereafter, with the single exception being IL-11 that was elevated at 8 h. (n-3)-PUFA consumption significantly suppressed DON-induced expression of IL-1alpha, IL-6, IL-11, MCP-1, MCP-3, MIP-2 and Fra-2 at 8 h. In contrast, mice fed (n-3)-PUFA exhibited significant increases in MKP1 and CnAbeta expression.	deoxynivalenol	200-203	mast cell protease 1	Mus musculus	250-255
15582125-7	2004	Curcumin prevented the MCD-induced activation of NF-kappaB and decreased downstream induction of ICAM-1, COX-2 and MCP-1.	Curcumin	0-8	mast cell protease 1	Mus musculus	115-120
15053818-9	2004	Furthermore, TMG attenuated the LPS-induced increase in pulmonary expression of KC, MIP-1alpha and MCP-1 at both the transcriptional and translational levels.	Betaine	13-16	mast cell protease 1	Mus musculus	99-104
15064234-7	2004	Consistent with this result, the expression of chemokines and adhesion molecules [such as ICAM-1, macrophage inflammatory protein (MIP)-1, MIP-2, and MCP-1] controlled by NF-kappaB is upregulated, whereas STAT1-controlled expression of chemokines (such as MIG and IP-10) is downregulated in ethanol-fed mice compared with pair-fed mice.	Ethanol	291-298	mast cell protease 1	Mus musculus	150-155
15236182-9	2004	Additionally, levels of TNF-alpha and nitric oxide were significantly reduced in both W/Wv and mMCP-1 deficient mice.	Nitric Oxide	38-50	mast cell protease 1	Mus musculus	95-101
15316134-6	2004	In contrast to the effect of dietary cholesterol, adding pravastatin to the drinking water significantly reduced eosinophil infiltration and the levels of IL-5, PGE(2) and MCP-1 in lavage fluid.	Pravastatin	57-68	mast cell protease 1	Mus musculus	172-177
15087825-3	2004	Consequently, piceatannol blocks the LPS-induced up-regulation of critical mediators of the inflammatory response such as interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), intercellular adhesion molecule 1 (ICAM-1), and macrophage chemoattractant protein (MCP-1).	3,3',4,5'-tetrahydroxystilbene	14-25	mast cell protease 1	Mus musculus	269-274
15315164-5	2004	The results showed that as compared with control group, M3 cholinergic receptor agonist (10(-3) mol/L, 10(-4) mol/L carbachol) could induce a concentration-dependent and time-dependent increase in the expression of MOB-1, MCP-1 mRNA in pancreatic acinar cells.	Carbachol	116-125	mast cell protease 1	Mus musculus	222-227
15084351-6	2004	Similarly, administration of dexamethasone to mice, previously administered LPS, results in an increase in GS and an inhibition of TNFalpha and MCP-1 in skeletal muscle tissue.	Dexamethasone	29-42	mast cell protease 1	Mus musculus	144-149
15315164-6	2004	After treatment with 10(-3) mol/L carbachol for 2 h, the expression of MOB-1, MCP-1 mRNA was strongest.	Carbachol	34-43	mast cell protease 1	Mus musculus	78-83
15315164-8	2004	Either M3 cholinergic receptor antagonist (10(-5) mol/L atropine) or NF-kappaB inhibitor (10(-2) mol/L PDTC) could obviously inhibit the activation of NF-kappaB and the chemokine MOB-1, MCP-1 mRNA expression induced by carbachol (P<0.05).	Atropine	56-64	mast cell protease 1	Mus musculus	186-191
14728887-12	2003	Yet curcumin could significantly decrease collagen type IV and III in the supernatant of cultured mesangial cells induced by LPS (20.5 +/- 1.00, P < 0.05 and 20.5 +/- 4.12 ng/ml, P < 0.05) and down-regulated the mRNA expression of IL-1 beta and MCP-1 in mesangial cells induced by LPS (P < 0.01).	Curcumin	4-12	mast cell protease 1	Mus musculus	251-256
12138127-5	2002	Ribonuclease protection assay revealed that the mRNA levels of chemokines such as IP-10 and MCP-1 in ear skin were markedly increased at 24 h after challenge with DNFB.	Dinitrofluorobenzene	163-167	mast cell protease 1	Mus musculus	92-97
14522423-9	2003	However, mRNA levels for MCP-1 were increased fivefold following 15 weeks of treatment with Celecoxib in comparison to non-treated control mice.	Celecoxib	92-101	mast cell protease 1	Mus musculus	25-30
14500682-3	2003	Administration of sodium cromoglycate (40 mg/kg, i.p., 1 h before Der f instillation), a mast cell stabilizer, not only suppressed acute mouse mast cell protease 1 production but also attenuated the allergic airway inflammation provoked by repetitive Der f challenge in mice (five times at 1-wk interval).	Cromolyn Sodium	18-37	mast cell protease 1	Mus musculus	143-163
14522253-6	2003	Cerivastatin reduced MCP-1 levels, whereas mecamylamine reduced VEGF levels and EPC.	cerivastatin	0-12	mast cell protease 1	Mus musculus	21-26
12709512-7	2003	Furthermore, the levels of the inflammation-related genes MCP-1, PAI, TF, IL-6, and ICAM-1 and the extent of lung inflammation were reduced during the initiation of caerulein-induced acute pancreatitis in EGR-1-deficient mice.	Ceruletide	165-174	mast cell protease 1	Mus musculus	58-63
12773512-7	2003	Activin A also showed activity in inducing migration of BMCMCs; the optimal concentration for maximal migration was 10 pM, which was much lower than the concentrations to inhibit cell growth and to activate the mMCP-1 gene.	bmcmcs	56-62	mast cell protease 1	Mus musculus	211-217
12471621-5	2003	The ribonuclease protection assay, using a multiprobe template set for human chemokines, revealed induction of not only IL-8 but also MCP-1 in doxorubicin-treated H69 cells.	Doxorubicin	143-154	mast cell protease 1	Mus musculus	134-139
12471621-9	2003	Thus, it is suggested that doxorubicin induces IL-8 and MCP-1 chemokines in human SCLC cells by activating gene expression, in which at least PEA3 is involved.	Doxorubicin	27-38	mast cell protease 1	Mus musculus	56-61
12939225-9	2003	Furthermore, rosuvastatin specifically suppressed the expression of the inflammation parameters MCP-1 and TNF-alpha in the vessel wall and lowered plasma concentrations of serum amyloid A and fibrinogen, independent of its cholesterol-lowering effect.	Rosuvastatin Calcium	13-25	mast cell protease 1	Mus musculus	96-101
12902868-10	2003	Celecoxib also significantly decreased C-C family chemokine (Rantes and MCP-1) mRNA expression in irradiated skin tissues, but not in tumor tissues, which was accompanied by a decrease in skin mRNA expression of both C-C (CCR2 and CCR5) and C-X-C (CXCR2 and CXCR4) chemokine receptors.	Celecoxib	0-9	mast cell protease 1	Mus musculus	72-77
12879250-11	2003	The inhibition of PNF by AsA was associated with decreased intra-islet levels of inflammation-related molecules (IL-1, TNF-alpha, iNOS, COX-2) and chemokines (MCP-1 and MIP-3alpha).	Aspirin	25-28	mast cell protease 1	Mus musculus	159-164
12505275-7	2003	The production of MCP-1 was enhanced by BPA treatment, but that of IL-6 was suppressed after infection.	bisphenol A	40-43	mast cell protease 1	Mus musculus	18-23
12138127-9	2002	Challenge with DNFB slightly induced IP-10 and MCP-1 mRNA in p38alpha +/- mice, with weaker signals than those in SB202190-treated wild-type mice.	Dinitrofluorobenzene	15-19	mast cell protease 1	Mus musculus	47-52
11518728-8	2001	Loss of MCP-1/CCR2 signaling, as seen in CCR2(-/-) mice or in WT mice treated with neutralizing antibodies to MCP-1, significantly reduced recruitment of mononuclear phagocytes following tracheal transplantation and led to attenuation of BOS.	N-[4-(Aminosulfonyl)phenyl]-2-Mercaptobenzamide	238-241	mast cell protease 1	Mus musculus	8-13
12235115-4	2002	We found significant upregulation of TNF-alpha, TGF-beta, RANTES, MIP-2, MCP-1, TCA3, IL-1beta, and ICAM-1 in kidneys from cisplatin-treated animals.	Cisplatin	123-132	mast cell protease 1	Mus musculus	73-78
12235115-6	2002	Inhibitors of TNF-alpha production (GM6001, pentoxifylline) and TNF-alpha Ab"s reduced serum and kidney TNF-alpha protein levels and also blunted the cisplatin-induced increases in TNF-alpha, TGF-beta, RANTES, MIP-2, MCP-1, and IL-1beta, but not ICAM-1, mRNA.	Cisplatin	150-159	mast cell protease 1	Mus musculus	217-222
12225870-7	2002	In contrast, the chemokines MIP-2 and MCP-1 showed enhanced levels of induction following NS-398 administration.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	90-96	mast cell protease 1	Mus musculus	38-43
12173416-10	2002	A significant increase in the TNF alpha and MCP-1 production by macrophages was also observed in the group fed high fat and cholesterol diet.	Cholesterol	124-135	mast cell protease 1	Mus musculus	44-49
11916915-10	2002	Oleate and palmitate also induced expression of chemokines (MCP-1 and GRO1 oncogene) and genes of the acute phase response (serum amyloid A3).	Oleic Acid	0-6	mast cell protease 1	Mus musculus	60-65
11916915-10	2002	Oleate and palmitate also induced expression of chemokines (MCP-1 and GRO1 oncogene) and genes of the acute phase response (serum amyloid A3).	Palmitates	11-20	mast cell protease 1	Mus musculus	60-65
11518728-10	2001	We suggest that MCP-1/CCR2 signaling plays an important role in recruitment of mononuclear phagocytes, a pivotal event in the pathogenesis of BOS.	N-[4-(Aminosulfonyl)phenyl]-2-Mercaptobenzamide	142-145	mast cell protease 1	Mus musculus	16-21
8603436-7	1996	Furthermore, pretreatment of T cells with either bisindolymaleimide HCl, a specific inhibitor of protein kinase C, or genistein, a protein tyrosine kinase inhibitor, significantly decreased the MCP-1-induced transmigration in a dose-dependent manner.	bisindolymaleimide hcl	49-71	mast cell protease 1	Mus musculus	194-199
10686507-1	2000	The effect of two Ca(2+) ATPase inhibitors, cyclopiazonic acid (CPA) and 2,5-di-(tert-butyl)-1,4-hydroquinone (DTBHQ), on the release of MCP-1 from bone marrow-derived mast cells (BMMCs) were investigated.	cyclopiazonic acid	44-62	mast cell protease 1	Mus musculus	137-142
10686507-1	2000	The effect of two Ca(2+) ATPase inhibitors, cyclopiazonic acid (CPA) and 2,5-di-(tert-butyl)-1,4-hydroquinone (DTBHQ), on the release of MCP-1 from bone marrow-derived mast cells (BMMCs) were investigated.	2,5-di-tert-butylhydroquinone	73-109	mast cell protease 1	Mus musculus	137-142
10686507-2	2000	CPA and DTBHQ increased the intracellular free Ca(2+) concentration ([Ca(2+)](i)) and induced MCP-1 release in a dose-dependent manner.	cyclopiazonic acid	0-3	mast cell protease 1	Mus musculus	94-99
10686507-2	2000	CPA and DTBHQ increased the intracellular free Ca(2+) concentration ([Ca(2+)](i)) and induced MCP-1 release in a dose-dependent manner.	2,5-di-tert-butylhydroquinone	8-13	mast cell protease 1	Mus musculus	94-99
10686507-4	2000	MCP-1 release reached a maximum at 6-9 h. It was inhibited by treatment with actinomycin D, the immunosuppressant cyclosporin A, and the cytosolic Ca(2+) chelator BAPTA-AM.	Dactinomycin	77-90	mast cell protease 1	Mus musculus	0-5
10686507-4	2000	MCP-1 release reached a maximum at 6-9 h. It was inhibited by treatment with actinomycin D, the immunosuppressant cyclosporin A, and the cytosolic Ca(2+) chelator BAPTA-AM.	Cyclosporine	114-127	mast cell protease 1	Mus musculus	0-5
10686507-4	2000	MCP-1 release reached a maximum at 6-9 h. It was inhibited by treatment with actinomycin D, the immunosuppressant cyclosporin A, and the cytosolic Ca(2+) chelator BAPTA-AM.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	163-171	mast cell protease 1	Mus musculus	0-5
10686507-7	2000	MCP-1 release was dose-dependently inhibited by the p38 MAP kinase inhibitor SB202190, but not by the p44/42 MAP kinase inhibitor PD98059.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	77-85	mast cell protease 1	Mus musculus	0-5
10555997-4	1999	Characteristic of dendritic cell maturation, R-848 treatment induces cell surface expression of CD83 and increases cell surface expression of CD80, CD86, CD40, and HLA-DR. Additionally, R-848 induces cytokine (IL-6, IL-12, TNF-alpha, IFN-alpha) and chemokine (IL-8, MIP-1alpha, MCP-1) secretion from dendritic cells.	resiquimod	45-50	mast cell protease 1	Mus musculus	278-283
10555997-4	1999	Characteristic of dendritic cell maturation, R-848 treatment induces cell surface expression of CD83 and increases cell surface expression of CD80, CD86, CD40, and HLA-DR. Additionally, R-848 induces cytokine (IL-6, IL-12, TNF-alpha, IFN-alpha) and chemokine (IL-8, MIP-1alpha, MCP-1) secretion from dendritic cells.	resiquimod	186-191	mast cell protease 1	Mus musculus	278-283
10476317-2	1999	In 1995, we found that MCP-1 provokes mast cell aggregation and [3H]5HT-release in cultured mast cells.	Tritium	65-67	mast cell protease 1	Mus musculus	23-28
10476317-2	1999	In 1995, we found that MCP-1 provokes mast cell aggregation and [3H]5HT-release in cultured mast cells.	Serotonin	68-71	mast cell protease 1	Mus musculus	23-28
10476317-6	1999	MCP-1 and RANTES provoked histamine release in intradermal mast cells and prostaglandin D2 generation.	Histamine	26-35	mast cell protease 1	Mus musculus	0-5
10476317-6	1999	MCP-1 and RANTES provoked histamine release in intradermal mast cells and prostaglandin D2 generation.	Prostaglandin D2	74-90	mast cell protease 1	Mus musculus	0-5
10476317-9	1999	In this paper, we found that MCP-1, strongly mediates the recruitment of mononuclear cells in the granuloma formed by KMnO4.	Potassium Permanganate	118-123	mast cell protease 1	Mus musculus	29-34
9137091-2	1997	Using a monoclonal antibody against the chymase mouse mast cell protease-1 (mMCP-1), we have shown that it is constitutively expressed in < or = 20% of esterase-positive (esterase+) IMMCs but not in esterase+ gastric mucosal mast cells (GMMCs) in normal BALB/c mice.	gmmcs	240-245	mast cell protease 1	Mus musculus	54-74
9137091-2	1997	Using a monoclonal antibody against the chymase mouse mast cell protease-1 (mMCP-1), we have shown that it is constitutively expressed in < or = 20% of esterase-positive (esterase+) IMMCs but not in esterase+ gastric mucosal mast cells (GMMCs) in normal BALB/c mice.	gmmcs	240-245	mast cell protease 1	Mus musculus	76-82
9137091-7	1997	In conclusion, mMCP-1 is predominantly expressed by intraepithelial mucosal mast cells but not in all sites; the immunological stimulus associated with intestinal nematodiasis substantially up-regulates mMCP-1 expression by mast cells in the jejunum but not in the stomach; IMMCs and GMMCs in BALB/c mice are phenotypically and possibly functionally distinct.	gmmcs	284-289	mast cell protease 1	Mus musculus	15-21
9137091-7	1997	In conclusion, mMCP-1 is predominantly expressed by intraepithelial mucosal mast cells but not in all sites; the immunological stimulus associated with intestinal nematodiasis substantially up-regulates mMCP-1 expression by mast cells in the jejunum but not in the stomach; IMMCs and GMMCs in BALB/c mice are phenotypically and possibly functionally distinct.	gmmcs	284-289	mast cell protease 1	Mus musculus	203-209
9127001-5	1997	As assessed by nuclear run-on and RNA blot analyses, dexamethasone inhibited the IL-10-mediated expression of mMCP-1 and mMCP-2, primarily by inducing rapid degradation of their transcripts.	Dexamethasone	53-66	mast cell protease 1	Mus musculus	110-116
10839200-0	2000	Secretion of MCP-1 and IL-6 by cytokine stimulated production of reactive oxygen species in endothelial cells.	Reactive Oxygen Species	65-88	mast cell protease 1	Mus musculus	13-18
10839200-8	2000	Cytokine induced release of MCP-1 and IL-6 by endothelial cells was completely inhibited in the presence of Tiron and Tempol, whereas NMMA was less effective.	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt	108-113	mast cell protease 1	Mus musculus	28-33
10839200-8	2000	Cytokine induced release of MCP-1 and IL-6 by endothelial cells was completely inhibited in the presence of Tiron and Tempol, whereas NMMA was less effective.	tempol	118-124	mast cell protease 1	Mus musculus	28-33
10839200-9	2000	Collectively these data indicate that cytokine stimulated endothelial cells increase their reactive oxygen species production probably via NADH oxidase and this production may critically be involved in the secretion of MCP-1 and IL-6.	Reactive Oxygen Species	91-114	mast cell protease 1	Mus musculus	219-224
9561924-7	1998	These results suggest that TC-120IP-induced migration of monocytes may be mediated through the generation of MCP-1 and TGF-beta by tubular cells.	tc-120ip	27-35	mast cell protease 1	Mus musculus	109-114
9191260-0	1997	Stimulation of tyrosine phosphorylation and phosphatidylinositol 3-kinase by MCP-1 in THP-1 cells.	Tyrosine	15-23	mast cell protease 1	Mus musculus	77-82
8603436-7	1996	Furthermore, pretreatment of T cells with either bisindolymaleimide HCl, a specific inhibitor of protein kinase C, or genistein, a protein tyrosine kinase inhibitor, significantly decreased the MCP-1-induced transmigration in a dose-dependent manner.	Genistein	118-127	mast cell protease 1	Mus musculus	194-199
7682557-12	1993	In contrast, mMCP-1 and mMCP-2, which are present in granules of mucosal mast cells that contain chondroitin sulfate, lack one of these regions and have a lower charge density in the other.	Chondroitin Sulfates	97-116	mast cell protease 1	Mus musculus	13-19
7578981-0	1995	Changes in the expression of MCP-1 receptors on monocytic THP-1 cells following differentiation to macrophages with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	116-141	mast cell protease 1	Mus musculus	29-34
7578981-7	1995	The reduction in specific binding of MCP-1 by M phi-THP-1 cells was due to a decrease in both receptor number and affinity; receptor number was reduced to 481 +/- 106 receptors/cells with a Kd of 3.16 +/- 0.7 nM on cells treated for 3 h with PMA.	Tetradecanoylphorbol Acetate	242-245	mast cell protease 1	Mus musculus	37-42
8145015-1	1994	The expression of the murine IP-10 and MCP-1 genes has been examined in the skin of mice during contact hypersensitivity reactions to the hapten trinitrochlorobenezene (TNCB).	trinitrochlorobenezene	145-167	mast cell protease 1	Mus musculus	39-44
8145015-1	1994	The expression of the murine IP-10 and MCP-1 genes has been examined in the skin of mice during contact hypersensitivity reactions to the hapten trinitrochlorobenezene (TNCB).	Picryl Chloride	169-173	mast cell protease 1	Mus musculus	39-44
8145015-8	1994	MCP-1 expression was rarely found associated with fur follicles but instead was distributed throughout the dermis in cells embedded in the collagenous extracellular matrix.	fur	50-53	mast cell protease 1	Mus musculus	0-5
33810307-5	2021	Furthermore, UB-EV-52 treatment increased body weight and lifespan by 25% and reduced gene expression of the inflammatory markers (i.e., Il-1beta and Mcp1) and enhanced oxidative stress (OS) markers (iNOS and Hmox1) in the treated Npc mice group.	ub-ev-52	13-21	mast cell protease 1	Mus musculus	150-154
33811972-4	2021	Ruxolitinib suppressed not only the production of IFN-gamma from CD4+ T cells and MCP-1 from CD11b+ macrophage/monocytes, but also the proliferation of these cells in vitro.	ruxolitinib	0-11	mast cell protease 1	Mus musculus	82-87
33811972-5	2021	Levels of both cytokines (IFN-gamma and MCP-1) were also reduced in the spleen and skin of ruxolitinib-treated recipients in vivo.	ruxolitinib	91-102	mast cell protease 1	Mus musculus	40-45
33034242-6	2020	Furthermore, loganin remarkably reduced macrophage M1 polarization in UC mice evidenced by reduced the number of F4/80 and iNOS dual-stained M1 macrophages, and the expression of M1 macrophage-related pro-inflammatory chemokines/cytokines including MCP-1, CXCL10 as well as COX-2.	loganin	13-20	mast cell protease 1	Mus musculus	249-254
29847555-7	2018	RESULTS: Gemcabene significantly downregulated hepatic mRNA markers of inflammation (TNF-alpha, MCP-1, MIP-1beta, CCR5, CCR2, NF-kappaB), lipogenesis and lipid modulation (ApoC-III, ACC1, ADH-4, Sulf-2), and fibrosis (TIMP-1 and MMP-2).	gemcabene	9-18	mast cell protease 1	Mus musculus	96-101
34924115-7	2022	The secreted pro-inflammatory factors (MCP1, GM-CSF and M-CSF) and M1 biomarker iNOS in synovium were inhibited by Wilforlide A.	wilforlide A	115-127	mast cell protease 1	Mus musculus	39-43
33811972-6	2021	IFN-gamma-induced MCP-1 production and migration of RAW 264.7 cells, a macrophage cell line, were inhibited by ruxolitinib.	ruxolitinib	111-122	mast cell protease 1	Mus musculus	18-23
33811972-7	2021	However, supplement of MCP-1 recovered such effect of ruxolitinib.	ruxolitinib	54-65	mast cell protease 1	Mus musculus	23-28
33811972-9	2021	Taken together, these results suggest that ruxolitinib can prevent scl-GVHD by suppressing IFN-gamma produced by T cells and MCP-1 expression in macrophage/monocytes via inhibition of JAK-STAT signaling.	ruxolitinib	43-54	mast cell protease 1	Mus musculus	125-130
22848208-6	2012	Fenofibrate increased renal expression of CYP4A, restored renal CYP2J expression, reduced the elevation in renal ICAM-1, MCP-1 and COX-2 in WT + Ang II mice.	Fenofibrate	0-11	mast cell protease 1	Mus musculus	121-126
34253875-6	2022	We showed that wogonin (4, 8, 16 muM) dose-dependently alleviated high glucose (HG)-induced MPC5 cell damage, accompanied by increased expression of WT-1, nephrin, and podocin proteins, and decreased expression of TNF-alpha, MCP-1, IL-1beta as well as phosphorylated p65.	wogonin	15-22	mast cell protease 1	Mus musculus	225-230
34861286-14	2022	Notably, doxorubicin elevated both MCP1 and TGFB1 gene expression in addition to increasing the protein expression of Smad3 and Jun N-terminal Kinase-1 (JNK1) while decreasing that of Smad7.	Doxorubicin	9-20	mast cell protease 1	Mus musculus	35-39
34861286-16	2022	SIGNIFICANCE: Pirfenidone and vitamin D demonstrated a viable approach to suppress the nephrotoxicity initiated by doxorubicin through inhibiting the JNK1 and MCP-1 pathways.	pirfenidone	14-25	mast cell protease 1	Mus musculus	159-164
34861286-16	2022	SIGNIFICANCE: Pirfenidone and vitamin D demonstrated a viable approach to suppress the nephrotoxicity initiated by doxorubicin through inhibiting the JNK1 and MCP-1 pathways.	Vitamin D	30-39	mast cell protease 1	Mus musculus	159-164
34861286-16	2022	SIGNIFICANCE: Pirfenidone and vitamin D demonstrated a viable approach to suppress the nephrotoxicity initiated by doxorubicin through inhibiting the JNK1 and MCP-1 pathways.	Doxorubicin	115-126	mast cell protease 1	Mus musculus	159-164
34915776-8	2021	Norgalanthamine also ameliorated inflammation by down-regulating the expression of the pro-inflammatory mediators, TNF-alpha, IL-1beta, and MCP-1, and up-regulating the Nrf2/HO-1 pathway.	norgalanthamine	0-15	mast cell protease 1	Mus musculus	140-145
34970414-6	2021	Immunohistochemical and zymography results show that CIH upregulated the expression and activity of MMP2 and MMP9 and upregulated MCP1 expression while downregulating alpha-SMA expression.	cih	53-56	mast cell protease 1	Mus musculus	130-134
34975482-4	2021	Furthermore, brevinin-2MP has been found to inhibit the lipopolysaccharide (LPS)-induced expression of pro-inflammatory NO, MCP-1, IL-6, and TNF-alpha via binding unidentified targets on the cell membrane and consequently suppressing the activation of MAPK/NF-kappaB signaling cascades induced by LPS in RAW 264.7 cells.	brevinin-2mp	13-25	mast cell protease 1	Mus musculus	124-129
34903499-8	2021	RESULTS: DSS-induced colitis increased steatosis, inflammatory (IL-6, TNFalpha, NLRP3, MCP-1) as well as fibrotic (TGF-beta, alpha-SMA) mediator expression in HFD-FG mice.	Dextran Sulfate	9-12	mast cell protease 1	Mus musculus	87-92
34955852-7	2021	Meanwhile, MaR1 administration obviously diminished pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1beta, and MCP-1), downregulated BAX and cleaved caspase-3 expression, and upregulated BCL-2 expression in the injured kidney tissues and TCMK-1 cells.	7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid	11-15	mast cell protease 1	Mus musculus	111-116
34416495-4	2021	Our results showed that HFPO-DA exposure caused colonic inflammation which was coupled with increased TNF-alpha levels in serum and increased mRNA expression levels of TNF-alpha, p65, TLR4, MCP-1 of the colon in mice after exposure to 200 mug/L HFPO-DA.	perfluorooctane	24-31	mast cell protease 1	Mus musculus	190-195
34938192-6	2021	Additionally, PEG-Loxe considerably inhibited oxidative stress, decreased pro-inflammatory factor (TNF-alpha, IL-6, and MCP-1) levels, and increased anti-inflammatory factor IL-10 levels.	polyethylene glycol loxenatide	14-22	mast cell protease 1	Mus musculus	120-125
34416495-4	2021	Our results showed that HFPO-DA exposure caused colonic inflammation which was coupled with increased TNF-alpha levels in serum and increased mRNA expression levels of TNF-alpha, p65, TLR4, MCP-1 of the colon in mice after exposure to 200 mug/L HFPO-DA.	perfluorooctane	245-252	mast cell protease 1	Mus musculus	190-195
34592488-13	2021	MCD also induced rising expression of typical genes and proteins related to fibrosis (fibronectin, alpha-SMA, collagens, TGF-beta) and inflammation (ILs, TNF-alpha, MCP-1), which was suppressed by low-dose triptolide.	triptolide	206-216	mast cell protease 1	Mus musculus	165-170
34538492-12	2021	In addition, significant reductions of allergen-specific IgE, IgG, histamine, and mMCP-1 were showed in HM-challenged mice, especially for histamine, ranging from 171.42 ng/mL to 214.94 ng/mL.	Histamine	139-148	mast cell protease 1	Mus musculus	82-88
34746942-4	2021	ATO could also reduce the levels of liver MDA, increase the activities of SOD and CAT, and reduce the levels of IL-1beta, MCP-1 and TNF-alpha.	ato	0-3	mast cell protease 1	Mus musculus	122-127
34737710-10	2021	Melatonin inhibited the activation of the NLRP3 inflammasome, thereby reducing the expression of IL-1beta and other related proinflammatory cytokines such as MCP-1, MIP-1, NLRP3, ASC, TNF-a and VEGF-A (all p < 0.05).	Melatonin	0-9	mast cell protease 1	Mus musculus	158-163
34693552-8	2022	Poly(I:C)-stimulated Hpse-/- bone marrow DCs (BMDCs) expressed less IL-12, and when cultured with Hpse-/- NK cells, less MCP-1 mRNA and protein was detected.	Poly I-C	0-9	mast cell protease 1	Mus musculus	121-126
34622729-7	2021	RESULTS: In mice administered piceatannol (12.5 mg/kg), the tumor number, tumor area, and Ki-67-positive cell numbers decreased by 30.1%, 57.2%, and 89.1%, respectively, colon MCP-1 and PD-1 levels showed reductions of 43.8% and 70.9%, respectively, and COX-2-positive cell numbers declined by 60.2%.	3,3',4,5'-tetrahydroxystilbene	30-41	mast cell protease 1	Mus musculus	176-181
34622729-8	2021	CONCLUSIONS: The inhibitory effects of piceatannol on AOM/DSS-induced colon tumor growth appear to be associated with reductions in colon MCP-1 and PD-1 levels through the downregulated expression of COX-2 in the tumor microenvironment.	3,3',4,5'-tetrahydroxystilbene	39-50	mast cell protease 1	Mus musculus	138-143
34622729-8	2021	CONCLUSIONS: The inhibitory effects of piceatannol on AOM/DSS-induced colon tumor growth appear to be associated with reductions in colon MCP-1 and PD-1 levels through the downregulated expression of COX-2 in the tumor microenvironment.	Azoxymethane	54-57	mast cell protease 1	Mus musculus	138-143
34622729-8	2021	CONCLUSIONS: The inhibitory effects of piceatannol on AOM/DSS-induced colon tumor growth appear to be associated with reductions in colon MCP-1 and PD-1 levels through the downregulated expression of COX-2 in the tumor microenvironment.	Dextran Sulfate	58-61	mast cell protease 1	Mus musculus	138-143
34271086-9	2021	Though the intracellular levels of pyroptosis-related cytokine caspase-1, cleaved caspase-1, NLRP3, IL-18, IL-1beta were upregulated both in MI and H2O2 stimulation, knockout of TN-C resisted such injury and alleviated cardiac pyroptosis, which further decreased IL-6, TNF-alpha, MCP-1 expression.	Hydrogen Peroxide	148-152	mast cell protease 1	Mus musculus	280-285
34568404-7	2021	In macrophages from obese mice fed with CRL1446 and CRL1434, after LPS stimulus, lower levels of MCP-1, TNF-alpha, IL-6 compared to obese control were observed.	crl1446	40-47	mast cell protease 1	Mus musculus	97-102
34242900-8	2021	Furthermore, MET in combination with genistein reduced the expression of TNF-alpha, IL-1beta, MCP-1, and IL-6 and increased the expression of IL-10 in comparison with genistein and MET groups alone.	Genistein	37-46	mast cell protease 1	Mus musculus	94-99
34242900-8	2021	Furthermore, MET in combination with genistein reduced the expression of TNF-alpha, IL-1beta, MCP-1, and IL-6 and increased the expression of IL-10 in comparison with genistein and MET groups alone.	Genistein	167-176	mast cell protease 1	Mus musculus	94-99
34568404-7	2021	In macrophages from obese mice fed with CRL1446 and CRL1434, after LPS stimulus, lower levels of MCP-1, TNF-alpha, IL-6 compared to obese control were observed.	crl1434	52-59	mast cell protease 1	Mus musculus	97-102
34504642-6	2021	Moreover, the status of oxidative stress and levels of inflammatory cytokines (TNF-alpha, IL-6, IL-1beta, and MCP-1) were markedly inhibited by YSPDF treatment.	yspdf	144-149	mast cell protease 1	Mus musculus	110-115
34245824-9	2021	Furthermore, 6-OAU treatment reduced ERK phosphorylation and MCP-1 secretion during Brucella infection as well as reduced MALT1 protein expression and ROS production in cells without infection.	6-OAU	13-18	mast cell protease 1	Mus musculus	61-66
34245824-10	2021	LU treatment attenuated ERK and JNK phosphorylation, MCP-1 secretion and NO accumulation but increased ROS production during infection, and similar pattern with MALT1 protein expression.	lauric acid	0-2	mast cell protease 1	Mus musculus	53-58
34424818-9	2021	Furthermore, HDL from the REP-based diet-fed mice significantly suppressed the inflammatory cytokine response of human umbilical vein endothelial cells than that from the casein-based diet-fed mice (MCP-1, p = 0.010; IL-6, p = 0.011; IL-1beta, p = 0.028).	N,N-DIETHYLBENZAMIDE	26-29	mast cell protease 1	Mus musculus	199-204
34485361-5	2021	In lycopene experimental groups, the amount of gastric juice were lower than that in the gastric injury control group; the levels of T-SOD, and the levels of MDA and inflammatory factors (MMP-9 and MCP-1) decreased.	Lycopene	3-11	mast cell protease 1	Mus musculus	198-203
34361736-10	2021	Finally, GT-73 reduced the levels of IL-1beta, IL-6, and MCP-1 in bronchoalveolar lavage fluid (BALF).	gt-73	9-14	mast cell protease 1	Mus musculus	57-62
34393799-11	2021	The levels of inflammatory mediators (TNF-alpha, IL-1beta, IL-6, IL-17A, MCP-1, MIG, IP-10, and CRP) in the lung homogenate were reduced after ISOF treatment.	Isof	143-147	mast cell protease 1	Mus musculus	73-78
35628290-6	2022	Here, we show that Oxy210 also inhibits diet-induced white adipose tissue inflammation in APOE*3-Leiden.CETP mice, evidenced by the inhibition of adipose tissue expression of IL-6, MCP-1, and CD68 macrophage marker.	oxy210	19-25	mast cell protease 1	Mus musculus	181-186
34134952-7	2021	The mice in DSS group had severe pathologies in the colon with significantly increased ratios of CD4+ and CD4+/CD8+ T cells in peripheral blood and LPL, increased levels of IL-6 and MCP-1 but no obvious changes in IL-10 in colon homogenate, and significantly augmented phosphorylation levels of ERK1/2, JNK and P38.	dss	12-15	mast cell protease 1	Mus musculus	182-187
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	dss	23-26	mast cell protease 1	Mus musculus	206-211
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	dss	46-49	mast cell protease 1	Mus musculus	206-211
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	rcshscb	51-58	mast cell protease 1	Mus musculus	206-211
35619631-10	2022	BDMC not only decreased the production of OVA-specific immunoglobulin (OVA-sIg)E, IgG1, histamine, mouse mast cell protease-1, diamine oxidase, cytokines (IL-4, IL-5 and IL-13) but increased cytokines interferon-gamma production.	bisdemethoxycurcumin	0-4	mast cell protease 1	Mus musculus	105-125
34061176-9	2021	cMet Ab treatment decreased inflammatory marker (MCP-1, TNF-alpha, and IL-1beta) expression, reduced Smurf1 and Smad2/3 level, and increased Smad7 expressions.	cmet ab	0-7	mast cell protease 1	Mus musculus	49-54
34072430-7	2021	AUY-922 suppressed the LPS-induced inflammation by inhibiting major pro-inflammatory pathways (e.g., JAK2/STAT3, MAPKs), and downregulated the IL-1beta, IL-6, MCP-1 and TNFalpha.	5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-morpholin-4-ylmethylphenyl)isoxazole-3-carboxylic acid ethylamide	0-7	mast cell protease 1	Mus musculus	159-164
35038590-10	2022	Moreover, RP-PU inhibited foam cell formation, decreased ICAM-1 and MCP-1 expression and delayed lesion formation.	rp-pu	10-15	mast cell protease 1	Mus musculus	68-73
35566338-9	2022	Results: In vivo, the improved levels of LPS-induced pro-inflammatory factors, including TNF-alpha, IL-6, IL-1beta, MCP-1 and ICAM-1 in the cortex and hippocampus, were reduced after ST2825 treatment.	ST2825	183-189	mast cell protease 1	Mus musculus	116-121
35566338-10	2022	In vitro, the levels of LPS-induced pro-inflammatory factors, including NO, TNF-alpha, IL-6, IL-1beta, MCP-1, iNOS, COX2 and ROS, were remarkably decreased after ST2825 treatment.	ST2825	162-168	mast cell protease 1	Mus musculus	103-108
35176443-7	2022	PEA treatment promoted an improvement in anxiety-like behavior of obese mice and the systemic inflammation, reducing serum pro-inflammatory mediators (i.e., TNF-alpha, IL-1beta, MCP-1, LPS).	palmidrol	0-3	mast cell protease 1	Mus musculus	178-183
35203043-8	2022	MSM treatment reduced the ethanol-induced inflammatory factors including myeloperoxidase (MPO), iNOS/NO, cyclooxygenase (COX)-2, nuclear factor kappa B (NF-kappaB), NLRP3 inflammasome and proinflammatory cytokines including TNF-alpha, IL-1beta, IL-6 and MCP-1.	dimethyl sulfone	0-3	mast cell protease 1	Mus musculus	254-259
35203043-8	2022	MSM treatment reduced the ethanol-induced inflammatory factors including myeloperoxidase (MPO), iNOS/NO, cyclooxygenase (COX)-2, nuclear factor kappa B (NF-kappaB), NLRP3 inflammasome and proinflammatory cytokines including TNF-alpha, IL-1beta, IL-6 and MCP-1.	Ethanol	26-33	mast cell protease 1	Mus musculus	254-259
35366186-14	2022	The results suggested that ICAM-1 is involved in the pathological processes by which HSV-1 induces facial paralysis in mice, and the treatment effects of MPSS for Bell"s palsy can be achieved by the inhibition of MCP-1.	Methylprednisolone Hemisuccinate	154-158	mast cell protease 1	Mus musculus	213-218
35332570-6	2022	Alpinetin inhibited macrophage adhesion and migration, and the expression of chemokines and adhesion molecules, such as MCP-1, VCAM-1, and ICAM-1.	alpinetin	0-9	mast cell protease 1	Mus musculus	120-125
35332570-11	2022	Finally, inhibition of Nrf2 in HFD-apoE-/- mice blockaded the effect of alpinetin, which increased aortic macrophage recruitment and aggravated atherosclerosis concurrently with elevating the expression of MCP-1, VCAM-1, and ICAM-1.	alpinetin	72-81	mast cell protease 1	Mus musculus	206-211
35244883-0	2022	Diacerein counteracts acetaminophen-induced hepatotoxicity in mice via targeting NLRP3/caspase-1/IL-1beta and IL-4/MCP-1 signaling pathways.	diacerein	0-9	mast cell protease 1	Mus musculus	115-120
35391841-10	2022	Mechanically, an increased level of tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1beta, IL-6, and MCP-1 were found in MI/R hearts, and Rg2 treatment significantly inhibit the expression of these factors.	rg2	147-150	mast cell protease 1	Mus musculus	110-115
35295759-10	2022	That effect was largely pronounced after treatment with aEVs, probably because the lung TNF-alpha, IFN-gamma, IL-6, and MCP-1 concentrations were specially increased in aEV-treated when compared with vEV-treated mice.	aevs	56-60	mast cell protease 1	Mus musculus	120-125
35498227-5	2022	Digoxin"s ameliorative effect on DN-hepatotoxicity coincided with (i) lowering the increased hepatic production and release of the proinflammatory mediators IL-17A, IL-1beta and TNF-alpha, and (ii) impeding the attraction and infiltration of monocytes to the liver, as denoted by decreasing serum MCP-1 and F4/80 immunohistochemical expression.	Digoxin	0-7	mast cell protease 1	Mus musculus	297-302
35295759-10	2022	That effect was largely pronounced after treatment with aEVs, probably because the lung TNF-alpha, IFN-gamma, IL-6, and MCP-1 concentrations were specially increased in aEV-treated when compared with vEV-treated mice.	2-(4,5-Dichloro-1h-Benzimidazol-2-Yl)-5-Methyl-4-[(1r)-3-Oxo-1,3-Dihydro-2-Benzofuran-1-Yl]-1,2-Dihydro-3h-Pyrazol-3-One	169-172	mast cell protease 1	Mus musculus	120-125
34979499-8	2022	Hippocampal IL-1beta, IL-6, and MCP-1 levels were significantly decreased in NKS-treated SAMP8 mice.	CHEMBL1089210	77-80	mast cell protease 1	Mus musculus	32-37
35215410-9	2022	At 2 days post-surgery for ischemia-reperfusion injury, oligosaccharides reduced kidney inflammation, serum creatine, MCP-1, IL-1beta, and TNF-alpha in AKI mice.	Oligosaccharides	56-72	mast cell protease 1	Mus musculus	118-123
3125111-3	1988	Similar I50 were measured with dansyl polymyxin as a probe for cell surface binding, suggesting that the initial binding site for MCP-1 and MCP-2 on the surface of cells was lipopolysaccharide.	dansyl polymyxin	31-47	mast cell protease 1	Mus musculus	130-135
33953829-14	2021	Mechanistically, EC-derived SO2 deficiency promoted HPAEC ICAM-1 and MCP-1 and the cocultured HPASMC Ki-67 and collagen I expression, which was abolished by andrographolide, an inhibitor of p50 (p < 0.05).	andrographolide	157-172	mast cell protease 1	Mus musculus	69-74
33789149-0	2021	Gamma-glutamyl carboxylated Gas6 facilitates the prophylactic effect of vitamin K in inhibiting hyperlipidemia-associated inflammatory pathophysiology via arresting MCP-1/ICAM-1 mediated monocyte-hepatocyte adhesion.	gamma-glutamyl carboxylated	0-27	mast cell protease 1	Mus musculus	165-170
33789149-0	2021	Gamma-glutamyl carboxylated Gas6 facilitates the prophylactic effect of vitamin K in inhibiting hyperlipidemia-associated inflammatory pathophysiology via arresting MCP-1/ICAM-1 mediated monocyte-hepatocyte adhesion.	Vitamin K	72-81	mast cell protease 1	Mus musculus	165-170
33938511-12	2021	Propranolol, amitriptyline, and ALM demonstrated lower serum MCP-1 7 days after AE.	Propranolol	0-11	mast cell protease 1	Mus musculus	61-66
33938511-12	2021	Propranolol, amitriptyline, and ALM demonstrated lower serum MCP-1 7 days after AE.	Amitriptyline	13-26	mast cell protease 1	Mus musculus	61-66
33919457-8	2021	The FCPLJ treatment decreased the level of GM-CSF, GRO-alpha, IL-1 beta, IL-6, MCP-1 and MIP-1 beta in the plasma of the infected mice.	fcplj	4-9	mast cell protease 1	Mus musculus	79-84
33495520-7	2021	COS administration suppressed the production of proinflammatory cytokines (TNF-alpha, IL-1beta, CXCL2 and MCP1) in the pancreas and ileums.	carbonyl sulfide	0-3	mast cell protease 1	Mus musculus	106-110
33116044-10	2021	In addition, the clinical-mimicking dose of sirolimus reduced the thickness of the intestinal mucosal layer, increased the intestinal permeability, and enriched the circulating pro-inflammatory factors, including IL-12, IL-6, MCP-1, GM-CSF, and IL-1beta.	Sirolimus	44-53	mast cell protease 1	Mus musculus	226-231
33731782-11	2021	The ischemic limbs of female mice treated with NIM-811 showed significantly lower levels of MCP-1, IL-23, IL-6, and IL-1alpha compared to limbs of vehicle-treated mice.	(melle-4)cyclosporin	47-54	mast cell protease 1	Mus musculus	92-97
33876343-11	2021	Firstly, the increased brain permeability and downregulated expression of tight junction proteins in the brain tissue induced by LPS were significantly reversed by treatment with Ramelteon, accompanied by the decrease in the production of IL-1beta and MCP-1 in the vessels in mice.	ramelteon	179-188	mast cell protease 1	Mus musculus	252-257
33429006-4	2021	High-sugar/fat (HSF) diet augmented the levels of the pro-inflammatory mediators MCP-1, IL-6, COX-2, and PGE2 in mammary tissue, and this was accompanied by crown-like structures of breast (CLS-B) formation and aromatase/estrogen upregulation.	Sugars	5-10	mast cell protease 1	Mus musculus	81-86
33429006-5	2021	Treatment with a COX-2 selective inhibitor, etoricoxib, decreased PGE2, IL-6, MCP-1, and CLS-B formation as well as reduced aromatase protein and estrogen levels in the mammary tissue of mice fed a HSF diet.	Etoricoxib	44-54	mast cell protease 1	Mus musculus	78-83
33868268-6	2021	We measured liver tissue and found that the EGCG gavage treatment significantly inhibited the pro-inflammatory factors (TNF-alpha, IL-1beta, IL-6, MCP-1, MIP-2, IFN-gamma) and oxidation indicators (MPO, NO, ALT, and AST) levels increase.	epigallocatechin gallate	44-48	mast cell protease 1	Mus musculus	147-152
33731782-12	2021	Similarly, male mice treated with NIM-811 showed significantly lower levels of MCP-1 and IL-1a.	(melle-4)cyclosporin	34-41	mast cell protease 1	Mus musculus	79-84
33614642-7	2021	Expressions of inflammatory markers MCP-1, F4/80 and ICAM, fibrotic markers type IV collagen and fibronectin, and the cytokine TGF-beta1 were increased in adenine-induced CKD when compared to control groups and significantly attenuated by metformin treatment.	Adenine	155-162	mast cell protease 1	Mus musculus	36-41
32896779-4	2021	TM-Tyr/CA decreased anaphylactic symptoms, and hindered the levels of IgG1, IgE, histamine, tryptase and mouse mast-cell protease-1 (mMCP-1) in mice sera.	Tyrosine	3-6	mast cell protease 1	Mus musculus	111-131
32896779-4	2021	TM-Tyr/CA decreased anaphylactic symptoms, and hindered the levels of IgG1, IgE, histamine, tryptase and mouse mast-cell protease-1 (mMCP-1) in mice sera.	Tyrosine	3-6	mast cell protease 1	Mus musculus	133-139
33796407-8	2021	Furthermore, the polarization of M0- to M2-like macrophages was impaired by CB-839, Trimetazidine, HX531, and Perhexiline, while Hx531 and Perhexiline also reduced MCP-1 secretion.	Perhexiline	139-150	mast cell protease 1	Mus musculus	164-169
33339641-10	2021	Additionally, in a rodent model of CIKI, mangiferin decreased the deposition of calcium oxalate (CaOX) crystals in mouse kidneys, alleviated the pathological damage to kidney tissue, and inhibited the upregulation of OPN, MCP1, and CD44 expression caused by CaOX crystals.	mangiferin	41-51	mast cell protease 1	Mus musculus	222-226
33146827-7	2021	Compared with group S, groups Au and Al had significantly shorter aortic diameters (group S vs Au vs Al; 2.29 vs 1.40 vs 1.36 mm, respectively, p < 0.01), reduced MMP-2 and MMP-9 activities, downregulated IL-6 and MCP-1 and upregulated expression of IGF-1 and TIMP-2.	Aluminum	37-39	mast cell protease 1	Mus musculus	214-219
33542347-12	2021	MK4 diminished levels of several cytokines and chemokines in liver, including IL-6, TNFalpha and MCP1, as measured by hepatic cytokine array.	menatetrenone	0-3	mast cell protease 1	Mus musculus	97-101
33546405-8	2021	Exercise, alone or in combination with DHA, significantly reversed the induction of proinflammatory genes (Mcp1, Il6, Tnfalpha, Tlr4) in DIO mice.	Docosahexaenoic Acids	39-42	mast cell protease 1	Mus musculus	107-111
33091778-7	2021	Exposure to BPA also reduced the anti- and pro-inflammatory cytokines IL-10, IL-6, IFN-gamma, and IL-7 in the epididymis, while the chemotaxis-associated cytokines CCL12, CCL17, CXCL16, and MCP-1 increased.	bisphenol A	12-15	mast cell protease 1	Mus musculus	190-195
33165140-7	2021	In addition, treatment of astragalin markedly decreased the secretion of inflammatory factors, including IL-6, MCP-1, TNF-alpha and IL-1beta.	astragalin	26-36	mast cell protease 1	Mus musculus	111-116
33406219-7	2021	D+Q-treated mice show significantly lower senescent cell (p16 and p21 expression) and inflammatory (Cxcl1, Il1beta, Il6, Mcp1 and Tnfalpha expression) burden in small and large intestine compared with control mice.	d+q	0-3	mast cell protease 1	Mus musculus	121-125
33467546-7	2021	RESULTS: Empagliflozin-treated mice exhibited reduced fasting glucose, total cholesterol and triglyceride serum levels, as well as decreased NAFLD activity score, decreased expression of lipogenic enzymes (Fasn, Screbp-1c and Pck-1) and inflammatory molecules (Mcp-1 and F4/80), compared to the Control group.	empagliflozin	9-22	mast cell protease 1	Mus musculus	261-266
32876525-6	2020	IL6 and MCP1 levels in the cell culture medium and mouse serum were induced by UA treatment.	ursolic acid	79-81	mast cell protease 1	Mus musculus	8-12
33279615-4	2021	Moreover, atorvastatin reversed microbial composition (characterized by increased abundance of Firmicutes and Lactobacillus and decreased Bacteroidetes abundance), increased fecal butyrate level, promoted intestinal barrier function (elevated protein levels of claudin-1, occludin and mucoprotein 2), as well as regulated intestinal immune function (decreased MCP-1, TNF-alpha and increased IL-10).	Atorvastatin	10-22	mast cell protease 1	Mus musculus	360-365
33310295-11	2021	MH lowered the levels of inflammation by reducing the AD enhanced expression of MCP-1 and COX-2 nearly threefold.	morin	0-2	mast cell protease 1	Mus musculus	80-85
32300244-9	2020	In H2O2-treated HK-2 cells, addition of PK (6 pg/mL) significantly decreased ROS production, regulated the expression of oxidant and antioxidant enzymes, suppressed the expression of TGF-beta1 and MCP-1, and inhibited cell apoptosis.	Hydrogen Peroxide	3-7	mast cell protease 1	Mus musculus	197-202
33952827-3	2021	In this study, it showed that Oridonin significantly improved kidney damage, and inhibited the expression of interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha and MCP-1, as well as macrophage marker F4/80 in kidney and the secretion of inflammatory cytokins in serum of AKI mice in vivo.	oridonin	30-38	mast cell protease 1	Mus musculus	177-182
33424997-5	2020	The results revealed that CUR, THC, and OHC dose-dependently inhibited the generation of NO and MCP-1 as well as the gene expression of MCP-1 and iNOS.	tetrahydrocurcumin	31-34	mast cell protease 1	Mus musculus	96-101
33424997-5	2020	The results revealed that CUR, THC, and OHC dose-dependently inhibited the generation of NO and MCP-1 as well as the gene expression of MCP-1 and iNOS.	tetrahydrocurcumin	31-34	mast cell protease 1	Mus musculus	136-141
33424997-5	2020	The results revealed that CUR, THC, and OHC dose-dependently inhibited the generation of NO and MCP-1 as well as the gene expression of MCP-1 and iNOS.	ohc	40-43	mast cell protease 1	Mus musculus	96-101
33424997-5	2020	The results revealed that CUR, THC, and OHC dose-dependently inhibited the generation of NO and MCP-1 as well as the gene expression of MCP-1 and iNOS.	ohc	40-43	mast cell protease 1	Mus musculus	136-141
33323915-17	2020	The paclitaxel effects were accompanied by inhibition of the inflammatory cytokines, MCP-1, TNF-alpha, TNF-R2, and TLR4, as well as attenuation of the apoptosis markers, Bax, Bcl-2, and Caspase-3.	Paclitaxel	4-14	mast cell protease 1	Mus musculus	85-90
33098615-7	2020	Tofogliflozin treatment enhanced damage in both the glomerular (i.e., enlarged mesangial area, increased foot process effacement rate, and decreased number of WT-1-positive cells) and tubulointerstitial (increased protein levels of KIM-1 and MCP-1, increased number of macrophages, and abnormal mitochondrial morphology) areas.	6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol	0-13	mast cell protease 1	Mus musculus	242-247
32767170-12	2020	Serum levels of IL-1alpha, IL-1beta, IL-6, IL-8, ICAM-1, MCP-1, and TNF-alpha were significantly lower in the DM-Acu than in the DM or DM-Sham groups.	dm-acu	110-116	mast cell protease 1	Mus musculus	57-62
33171990-5	2020	In the retinas of high-dose COS-treated mice, the nuclear translocation of NF-kappaB subunit (p65) was suppressed, and the expression of several key EAU inflammatory mediators, IFN-gamma, TNF-alpha, IL-1alpha, IL-4, IL-5, IL-6, IL-10, IL-17 and MCP-1 was lowered.	carbonyl sulfide	28-31	mast cell protease 1	Mus musculus	245-250
32603019-6	2020	LPS-induced activation of microglial cells and elevation in protein expression of inflammatory cytokines including IL-1beta, RANTES and MCP-1 in hypothalamus of mice were abrogated by pre-treatment with PG extract.	pg extract	203-213	mast cell protease 1	Mus musculus	136-141
32861799-12	2020	Besides the inhibition of c-jun/JNK, MCP-1 expression can be attenuated by inhibiting stat1 and ERK under high glucose condition after LPS stimulation.	Glucose	111-118	mast cell protease 1	Mus musculus	37-42
32687983-4	2020	Cytokines and chemokines such as CD68, IL1beta, MCP-1, and TNF-alpha, as well as alpha-SMA were increased in the groups that were exposed to MC-LR with the high-fat diet compared to the vehicle group.	cyanoginosin LR	141-146	mast cell protease 1	Mus musculus	48-53
33095778-11	2020	RESULTS: The URO-MCP-1 mouse model for IC/BPS was found to have a significant increase in bladder permeability, following liposaccharide (LPS) exposure, compared to saline-treated controls.	liposaccharide	122-136	mast cell protease 1	Mus musculus	17-22
33105887-9	2020	Thus, immunohistochemical analysis of VAT showed an increase in MCP-1 and IL-6 staining in HF + PA-fed mice but not in HF + LA-fed mice compared to CD controls.	Palmitic Acid	96-98	mast cell protease 1	Mus musculus	64-69
32083746-2	2020	EPSAH could significantly enhance macrophage phagocytosis and the secretion of nitric oxide, increase the mRNA expression levels of the pro-inflammatory cytokines (IL-1beta, IL-6, IL-12 and TNF-alpha), anti-inflammatory cytokine IL-10, and chemokines (MCP-1 and MIP-1alpha).	epsah	0-5	mast cell protease 1	Mus musculus	252-257
33081290-4	2020	On the basis of the mouse model, we found viridicatol to alleviate the allergy symptoms; decrease the levels of specific immunoglobulin E, mast cell protease-1, histamine, and tumor necrosis factor-alpha; and promote the production of interleukin-10 in the serum.	viridicatol	42-53	mast cell protease 1	Mus musculus	139-159
33026256-8	2020	RESULTS: IR 3T3-L1 adipocytes treated with PCB126 had significantly higher adipokine (adiponectin, IL-6, MCP-1, TNF-alpha) secretion and lower mitochondrial function, glucose uptake, and glycolysis.	3,4,5,3',4'-pentachlorobiphenyl	43-49	mast cell protease 1	Mus musculus	105-110
31510860-6	2020	Renal gene expression of Cdkn1a, KIM-1, NGAL and MCP-1 was increased by most of the STZ doses.	Streptozocin	84-87	mast cell protease 1	Mus musculus	49-54
32842681-4	2020	We demonstrated that OXY strongly decreased the release of IL-6 and MCP-1 from HMC3 cells stimulated with IL-1beta.	puag-haad	21-24	mast cell protease 1	Mus musculus	68-73
32384574-12	2020	Gentamicin administration induced relative systemic inflammation, which may be related to increase in the mRNA levels of TLR2 results in gene expression of proinflammatory chemokines and cytokines including IL-1beta, TNF-alpha, and MCP-1 in immune cells.	Gentamicins	0-10	mast cell protease 1	Mus musculus	232-237
32898015-0	2020	SIRT3 Ablation Deteriorates Obesity-Related Cardiac Remodeling by Modulating ROS-NF-kappaB-MCP-1 Signaling Pathway.	ros	77-80	mast cell protease 1	Mus musculus	91-96
32898015-9	2020	We presumed that SIRT3 ablation-mediated MCP-1 upregulation is attributed to ROS-NF-kappaB activation.	ros	77-80	mast cell protease 1	Mus musculus	41-46
32898015-10	2020	Thus, we concluded that SIRT3 prevents obesity-related cardiac remodeling by attenuating cardiac inflammation and fibrosis, through modulation of ROS-NF-kappaB-MCP-1 pathway.	ros	146-149	mast cell protease 1	Mus musculus	160-165
30903157-6	2020	NTBI causes iron overload, induces reactive oxygen species production and apoptosis in cultured vascular cells, and stimulates massive MCP-1-mediated monocyte recruitment, well-established mechanisms contributing to atherosclerosis.	ntbi	0-4	mast cell protease 1	Mus musculus	135-140
32361570-6	2020	Mice treated with 5-Aza showed a significant reduction of lung neutrophilia, together with lower expressions of CXCL2 and MCP-1.	Azacitidine	18-23	mast cell protease 1	Mus musculus	122-127
32296336-10	2020	NF-kappaB nuclear translocation, MCP-1 secretion, and ICAM-1 expression were also inhibited in BA-5-treated HSCs.	ba-5	95-99	mast cell protease 1	Mus musculus	33-38
32333917-4	2020	The underlying mechanisms behind capmatinib protective effect were found to be i) limiting excessive generation of reactive oxygen species by decreasing the level of lipid peroxidation and nitrosative stress products; and ii) suppressing overproduction of pro-inflammatory mediators like TNF-alpha and IL-6 that coincided with less inflammatory cell infiltration as denoted by lower levels of serum MCP-1 and Ly6G immunostaining.	capmatinib	33-43	mast cell protease 1	Mus musculus	399-404
32477107-8	2020	The absence of 5-HT, through the pharmaceutical blockade of Tph1 (LP533401) and dietary control (TRP-free diet), suppressed hepatic lipid load and the expression of inflammatory factors (Tnfalpha, Il6, and Mcp-1).	Serotonin	15-19	mast cell protease 1	Mus musculus	206-211
32114052-10	2020	In in vitro studies, methylglyoxal (MGO), a precursor of AGEs, significantly increased the expression of inflammatory molecules such as MCP-1 and TNF-alpha in a murine macrophage cell line, RAW264.7.	Pyruvaldehyde	21-34	mast cell protease 1	Mus musculus	136-141
32114052-10	2020	In in vitro studies, methylglyoxal (MGO), a precursor of AGEs, significantly increased the expression of inflammatory molecules such as MCP-1 and TNF-alpha in a murine macrophage cell line, RAW264.7.	Pyruvaldehyde	36-39	mast cell protease 1	Mus musculus	136-141
32411289-8	2020	Moreover, uvaol significantly reduces mRNA expression and production of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1beta, and MCP-1) and infiltration of macrophages in colonic tissues of colitis mice.	uvaol	10-15	mast cell protease 1	Mus musculus	131-136
32388084-6	2020	In an acute mouse model of atherosclerosis, ALE suppressed TNF-alpha-induced monocyte infiltration of the vascular endothelium and the expression of genes encoding inflammatory cytokines including IL-1beta, IL-6, TNF-alpha, and MCP-1 in the mouse aorta.	Epinephrine	44-47	mast cell protease 1	Mus musculus	228-233
31486527-3	2020	Administration of a specific Nln inhibitor Agaricoglyceride A (AgaA) to mice after stroke in a middle cerebral artery occlusion model (MCAO), dose-dependently aggravated injury measured by increased infarct and edema volumes, blood-brain barrier disruption, increased levels of IL-6 and MCP-1, neurological and motor deficit 24 h after stroke.	agaricoglyceride A	43-61	mast cell protease 1	Mus musculus	287-292
31486527-3	2020	Administration of a specific Nln inhibitor Agaricoglyceride A (AgaA) to mice after stroke in a middle cerebral artery occlusion model (MCAO), dose-dependently aggravated injury measured by increased infarct and edema volumes, blood-brain barrier disruption, increased levels of IL-6 and MCP-1, neurological and motor deficit 24 h after stroke.	agaricoglyceride A	63-67	mast cell protease 1	Mus musculus	287-292
31530901-5	2020	PE injection caused cardiac dysfunction and cardiac inflammation, evidenced by the increased expression of inflammatory cytokine IL-6 and chemokines MCP-1 and MCP-5, as well as macrophage infiltration in myocardium.	Phenylephrine	0-2	mast cell protease 1	Mus musculus	149-154
32091078-7	2020	Sphingolipid inhibitors downregulated the expression of MCP-1 and its receptor CCR2, which play a key role in monocyte recruitment.	Sphingolipids	0-12	mast cell protease 1	Mus musculus	56-61
32182914-9	2020	Myricitrin also significantly lowered plasma MCP-1 and TNF-alpha levels and the mRNA expression of hepatic pro-inflammatory genes.	myricitrin	0-10	mast cell protease 1	Mus musculus	45-50
32258175-7	2020	PYR-41 did not alter circulating immune cells determined by flow cytometry but significantly reduced aortic mRNA levels of cytokines related to monocyte recruitment (Mcp-1, Vcam-1, and Icam-1) and macrophage proinflammatory responses (Il-1beta and Il-6).	4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester	0-6	mast cell protease 1	Mus musculus	166-171
32079232-9	2020	Amphenmulin enhanced wound closure and promoted the healing of wound, which inhibited MRSA bacterial counts in the wound and decreased serum levels of the pro-inflammatory cytokines TNF-alpha, IL-6, and MCP-1.	amphenmulin	0-11	mast cell protease 1	Mus musculus	203-208
32079307-7	2020	In particular, AL extract decreased lipopolysaccharide (LPS)-mediated production and secretion of cytokines and chemokine, including IL-6, TNF-alpha, and MCP-1.	Aluminum	15-17	mast cell protease 1	Mus musculus	154-159
31928222-8	2020	We noted a significant rise in plasma FFAs, ALT, and MCP-1 in HF+ET-fed mice, which was blunted in HF+ET+Nano-treated mice.	Ethanol	65-67	mast cell protease 1	Mus musculus	53-58
31954762-9	2020	We further confirmed that DEX pretreatment reversed the EtOH-induced microglia activation in the DG as well as the upregulation of the hippocampal TNFalpha, MCP-1, IL-6, and IL-1beta mRNA levels.	Dexmedetomidine	26-29	mast cell protease 1	Mus musculus	157-162
31992349-6	2020	RESULTS: Our analysis revealed that pathology associated with either db/db, HFD, or STZ models yielded upregulation of a broad profile of cytokines, including chemokines (e.g., MIP-1alpha, MIP-1beta, and MCP-1) and pro-inflammatory cytokines, including IL-1alpha, IFN-gamma, and IL-3.	Streptozocin	84-87	mast cell protease 1	Mus musculus	204-209
32019160-3	2020	The results show that epididymal fat Mcp-1 and Rantes mRNA levels, which were higher in obese mice compared with lean mice, were significantly down-regulated by vitamin D supplementation.	Vitamin D	161-170	mast cell protease 1	Mus musculus	37-42
32019160-5	2020	In accordance with these in vivo findings, the in vitro 1,25(OH)2D3 treatment decreased IL-6, MCP-1, and IL-1beta production by SVCs from obese mice, but not by adipocytes.	25-hydroxyvitamin D3-bromoacetate	56-67	mast cell protease 1	Mus musculus	94-99
31901621-4	2020	Cu-CPT22, a TLR2 antagonist, down-regulated Pam3CSK4-induced production of IL-6, MCP-1, and MIP-1alpha, but not TNF-alpha.	Copper	0-2	mast cell protease 1	Mus musculus	81-86
31705064-5	2020	Interestingly, metformin decreased omental metastasis at least partially by inhibiting MCP-1 secretion from adipocytes independent of direct effects on cancer cells.	Metformin	15-24	mast cell protease 1	Mus musculus	87-92
31979265-7	2020	Furthermore, the anti-inflammatory properties of 4-HAB were confirmed in a mouse model of uric acid crystals-mediated peritonitis by the reduced levels of neutrophil influx, IL-1beta, active caspase-1, IL-6 and MCP-1 in lavage fluids.	auxarconjugatin A	49-54	mast cell protease 1	Mus musculus	211-216
31921356-7	2020	Remarkably, the inflammation-ameliorating effects of carvacrol treatment were not restricted to the intestinal tract, but could also be observed in extra-intestinal organs such as liver, kidneys and lungs and, strikingly, systemically as indicated by lower IFN-gamma, TNF, MCP-1 and IL-6 serum concentrations in carvacrol versus placebo treated mice.	carvacrol	53-62	mast cell protease 1	Mus musculus	273-278
32009945-12	2019	Conversely, the wounds treated with ATP-vesicles showed significantly higher expression of MCP-1 and stem cell markers (CD44, CD106, CD146, and CD34) at day 1, significantly higher IL-1beta and TNF-alpha expression from day 1-4, and significantly higher VEGF-A, VEGF-D, and VEGFR-2 expression from day 4-6 when compared to the controls.	Adenosine Triphosphate	36-39	mast cell protease 1	Mus musculus	91-96
31709729-2	2019	We show that cobalt protoporphyrin IX (CoPP) increases plasma concentrations of G-CSF, IL-6, and MCP-1 in mice, triggering the mobilization of granulocytes and hematopoietic stem and progenitor cells (HSPC).	cobaltiprotoporphyrin	13-37	mast cell protease 1	Mus musculus	97-102
32345030-7	2020	LPS-induced activation of microglial cells and elevation in expression of inflammatory cytokines including IL-1beta, RANTES, and MCP-1 in the prefrontal cortex of mice were effectively abrogated by muscone, which significantly down-regulated expression of TLR4, MyD88, Caspase-1, NLRP3, renin, and Ang II.	muscone	198-205	mast cell protease 1	Mus musculus	129-134
29808705-6	2020	Results The cetylated fatty acids mixture from Celadrin significantly decreased the production of IL-6, MCP-1, and TNF, key regulators of the inflammatory process, in stimulated RAW264.7 mouse macrophage cells.	Fatty Acids	22-33	mast cell protease 1	Mus musculus	104-109
29808705-6	2020	Results The cetylated fatty acids mixture from Celadrin significantly decreased the production of IL-6, MCP-1, and TNF, key regulators of the inflammatory process, in stimulated RAW264.7 mouse macrophage cells.	celadrin	47-55	mast cell protease 1	Mus musculus	104-109
29808705-8	2020	Conclusion The cetylated fatty acids mixture from Celadrin reduces inflammation in vitro by significantly decreasing the expression of IL-6, MCP-1, and TNF in stimulated RAW264.7 mouse macrophage cells.	Fatty Acids	25-36	mast cell protease 1	Mus musculus	141-146
29808705-8	2020	Conclusion The cetylated fatty acids mixture from Celadrin reduces inflammation in vitro by significantly decreasing the expression of IL-6, MCP-1, and TNF in stimulated RAW264.7 mouse macrophage cells.	celadrin	50-58	mast cell protease 1	Mus musculus	141-146
31347703-8	2019	Amelioration of pancreatic damage by butyrate was associated with reduced levels of TNF-alpha, IL-6 and MCP-1 and suppressed NLRP3 inflammasome activation in both pancreas and colon.	Butyrates	37-45	mast cell protease 1	Mus musculus	104-109
31759113-7	2020	Dabigatran decreased the expression of inflammatory molecules (e.g., MCP-1 and ICAM-1) in the aorta of diabetic mice.	dabigatran	0-10	mast cell protease 1	Mus musculus	69-74
31709729-2	2019	We show that cobalt protoporphyrin IX (CoPP) increases plasma concentrations of G-CSF, IL-6, and MCP-1 in mice, triggering the mobilization of granulocytes and hematopoietic stem and progenitor cells (HSPC).	cobaltiprotoporphyrin	39-43	mast cell protease 1	Mus musculus	97-102
31626919-9	2019	Mechanistically, miR-124 directly targeted signal transducer and activator of transcription 3 (STAT3) in BV2 cells; in addition, upregulation of miR-124 inhibited the increase of inducible nitric oxide synthetase and proinflammatory cytokines, including IL-6, IL-1beta, TNF-alpha, and MCP-1, in LPS-stimulated BV2 cells.	Nitric Oxide	189-201	mast cell protease 1	Mus musculus	285-290
31549892-7	2019	Expressions of the proinflammatory genes NF-kappaB, TLR2, MCP1, and TNF-alpha were also lower in the WAT of myricitrin-supplemented mice.	myricitrin	108-118	mast cell protease 1	Mus musculus	58-62
31749764-7	2019	Finally, melatonin supplementation reduced the crown-like-structure (CLS) formation, characteristic of the inflammatory process by macrophage infiltration into white adipose tissue of obese subjects, as well as decreased the gene expression of inflammation-related factors, such as leptin and MCP1.	Melatonin	9-18	mast cell protease 1	Mus musculus	293-297
31595923-3	2019	In this study, we demonstrated that DMY could upregulate the rectal temperature, suppress the development of diarrhea, decrease the levels of serum specific immunoglobulin (Ig)E, histamine, and mouse mast cell protease-1, and promote the production of interleukin-10 in ovalbumin-allergic mice.	dihydromyricetin	36-39	mast cell protease 1	Mus musculus	200-220
31271845-7	2019	DSS treated-P2ry6-/- mice showed increased histological damage and increased neutrophil and macrophage infiltration that correlated with increased mRNA levels of the chemokines KC and MCP-1.	dss	0-3	mast cell protease 1	Mus musculus	184-189
31486774-4	2019	As per the recommendation of a local government agency, we performed a pilot study and confirmed that repetitive administration of buprenorphine indeed markedly elevated circulating levels of four sepsis surrogate markers (e.g., IL-6, KC, MCP-1 and G-CSF) in 20- 60% of septic animals.	Buprenorphine	131-144	mast cell protease 1	Mus musculus	239-244
31323300-10	2019	A total of 12 beta-carboline alkaloids were identified in Part1 and they all showed suppressive effect on inflammatory cytokines including MCP-1, TNF-alpha, IL-6 and IL-1beta through inhibition of NF-kb/p65 phosphorylation, and that epithelial-mesenchymal transition (EMT) process was reversed by different compounds in different levels.	beta-carboline alkaloids	14-38	mast cell protease 1	Mus musculus	139-144
31647861-8	2019	Additionally, BITC-induced dying U937 cells released lower levels of chemoattractants, such as IL-8 and MCP-1, when compared to cells undergoing classical apoptosis.	benzyl isothiocyanate	14-18	mast cell protease 1	Mus musculus	104-109
31395340-2	2019	Our results demonstrated that Verapamil reduced LPS-induced pathological damage of the lung tissue, infiltration of inflammatory cells and the production of IL-1beta, TNF-alpha, and MCP-1 in the serum.	Verapamil	30-39	mast cell protease 1	Mus musculus	182-187
31419710-0	2019	Retinoic acid modulates IL-4, IL-10 and MCP-1 pathways in immune mediated hepatitis and interrupts CD4+ T cells infiltration.	Tretinoin	0-13	mast cell protease 1	Mus musculus	40-45
31545273-5	2019	BA reduced the serum levels of pro-inflammatory cytokines, such as IL-1alpha, IL-1beta, IL-5, IL-6, GM-CSF, KC, MCP-1 and PGE2 in Carr-treated mice, and increased those of anti-inflammatory cytokines, such as IL-12.	betulinic acid	0-2	mast cell protease 1	Mus musculus	112-117
31150720-8	2019	RESULTS: The combined treatment of hUCMSCs and Resveratrol can reduce BG, BUN, SCr, 24-h UAER, and the expression of the inflammatory factors MCP-1, RAGE and NF-kB; increase the number of podocytes and the expression of the podocyte-related proteins nephrin and WT1 in type 1 diabetes mellitus, and improve renal pathological structure.	Resveratrol	47-58	mast cell protease 1	Mus musculus	142-147
31419710-10	2019	A significant decrease in the measured cytokines TNF-alpha and IL-4 was observed in ConA + RA group in addition to a decrease in MCP-1 level.	Tretinoin	91-93	mast cell protease 1	Mus musculus	129-134
31489938-8	2019	In the EPI depot, melatonin reversed the increase of leptin, Il-6, Mcp-1 and Tnf-alpha triggered by obesity.	Melatonin	18-27	mast cell protease 1	Mus musculus	67-72
31412290-9	2019	Trehalose reduced the mRNA and secreted cytokines levels of IL-6, IL-8 and MCP-1 in corneal cells under TNF-alpha and desiccation stress mediated inflammation compared to controls.	Trehalose	0-9	mast cell protease 1	Mus musculus	75-80
31546603-8	2019	Interestingly, the IL-1beta, IL-6, MCP-1, and ICAM-1 mRNA levels, which were increased in KK-Ay mouse kidneys as compared with normal controls, were suppressed by febuxostat administration.	febuxostat	163-173	mast cell protease 1	Mus musculus	35-40
31484989-5	2019	This result suggests that the immune signaling initiated by Mcp1 leads instead to the inhibition of cellular oxygen usage, for which mitochondrial respiration is an obvious target.	Oxygen	109-115	mast cell protease 1	Mus musculus	60-64
31287602-7	2019	In addition, treatment with beta-carotene suppressed protein levels of TNF-alpha, IL-1beta and MCP-1, as well as mRNA expression associated with IL-1beta, IL-6, IL-4 and Par-2 in skin tissues.	beta Carotene	28-41	mast cell protease 1	Mus musculus	95-100
31252263-5	2019	We observed that resveratrol improved CCL4-induced liver fibrosis, upregulated Kupffer cells, increased the expression of IL-10 and M(IL-4) marks including Mrc1, Mrc2, CD163 and Arg1, whereas it slightly suppressed the level of M(LPS) including iNOS, TNF-alpha and MCP1.	Resveratrol	17-28	mast cell protease 1	Mus musculus	265-269
31552040-6	2019	At day 6 post-infection, 25-OH-cholecalciferol treated mice displayed lower numbers of colonic innate and adaptive immune cell populations as compared to placebo controls that were accompanied by lower intestinal concentrations of pro-inflammatory mediators including IL-6, MCP1, and IFN-gamma.	25-oh-cholecalciferol	25-46	mast cell protease 1	Mus musculus	274-278
31363726-11	2019	The results showed that CMP suppressed the expressions of CD68, IL-1beta, IL-6, and MCP-1 mRNA induced by STZ.	Streptozocin	106-109	mast cell protease 1	Mus musculus	84-89
30953775-8	2019	In diabetic mice with pMCAo, proinflammatory mediators (IL-1beta, MCP1, TNFalpha and CD68) were significantly higher than in non-diabetic mice.	pmcao	22-27	mast cell protease 1	Mus musculus	66-70
31452696-7	2019	After the mice were given TAK-242, the levels of hs-CPR, MCP-1, IL-6 and IL-1beta in the PT group evidently increased (P&lt;0.01) compared with those in the N group.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	26-33	mast cell protease 1	Mus musculus	57-62
31302373-6	2019	Luteolin supplementation also significantly lowered mRNA expression of inflammatory and M1 markers MCP-1, CD11c, TNF-alpha and IL-6, while maintaining expression of M2 marker MGL1.	Luteolin	0-8	mast cell protease 1	Mus musculus	99-104
31132306-5	2019	Upon TPPU treatment, the liver steatosis and inflammatory damage were significantly ameliorated in mice with steatohepatitis, paralleled by the downregulation of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) as well as chemokines (CXCL1, MCP-1).	TPPU	5-9	mast cell protease 1	Mus musculus	247-252
32305963-4	2019	The inflammatory factors of TNF-alpha, IL-1beta, IL-6, and MCP1 were also significantly reduced by GYY4137.	GYY 4137	99-106	mast cell protease 1	Mus musculus	59-63
31195080-4	2019	Although empagliflozin significantly reduced Vcam-1 and Mcp-1 (P &lt; 0.05, P &lt; 0.01, respectively) and marginally induced Timp-1 and Timp-2 mRNA expression (P &lt; 0.08, P = 0.1 respectively), immunohistochemistry revealed a marginal reduction in VCAM-1 and MMP-9 (P = 0.1) without affecting the expression of TIMP-2 and MCP-1 in atherosclerotic lesions.	empagliflozin	9-22	mast cell protease 1	Mus musculus	56-61
31195080-4	2019	Although empagliflozin significantly reduced Vcam-1 and Mcp-1 (P &lt; 0.05, P &lt; 0.01, respectively) and marginally induced Timp-1 and Timp-2 mRNA expression (P &lt; 0.08, P = 0.1 respectively), immunohistochemistry revealed a marginal reduction in VCAM-1 and MMP-9 (P = 0.1) without affecting the expression of TIMP-2 and MCP-1 in atherosclerotic lesions.	empagliflozin	9-22	mast cell protease 1	Mus musculus	325-330
31497235-4	2019	RSV inhibited the expression of M1-like macrophage-related biomarkers (e.g., TNF-alpha and MCP-1) when bone marrow-derived macrophages (BMDMs) were stimulated with lipopolysaccharide (LPS) and interferon-gamma (INF-gamma).	Resveratrol	0-3	mast cell protease 1	Mus musculus	91-96
31292344-5	2019	In addition, beta-carotene significantly suppressed protein expression of TNF-alpha, IL-1beta, and MCP-1 and mRNA expression of TSLP, IL-6, IL-1beta, IL-4, IL-5, and Par-2 in AD-like skin tissues.	beta Carotene	13-26	mast cell protease 1	Mus musculus	99-104
31340484-9	2019	It was found that the production of NO and MCP-1 was obviously inhibited by three coumarins.	Coumarins	82-91	mast cell protease 1	Mus musculus	43-48
31362373-9	2019	In addition, EGCG treatment attenuated colon inflammation by suppressing colonic levels of pro-inflammatory cytokines IL-6, MCP-1, and TNF-alpha, and inhibited CD3+ T cell and CD68+ macrophage infiltration.	epigallocatechin gallate	13-17	mast cell protease 1	Mus musculus	124-129
31210194-4	2019	Cinnamaldehyde treatment significantly decreased inflammatory cytokine (TNF-alpha, IL-6, NO and MCP-1) overproduction and the serum lipid level.	cinnamaldehyde	0-14	mast cell protease 1	Mus musculus	96-101
31029908-11	2019	Curcumin also attenuated the high expression of IL-6, MCP-1, OPN, CD44, alpha-SMA, Collagen I and collagen fibril deposition, which were elevated by hyperoxaluria.	Curcumin	0-8	mast cell protease 1	Mus musculus	54-59
31367234-5	2019	Results: Canagliflozin administration to NA/STZ/Suc mice normalized hyperglycemia as well as elevated renal mRNA of collagen 1a1, 1a2, CTGF, TNFalpha and MCP-1.	Canagliflozin	9-22	mast cell protease 1	Mus musculus	154-159
31379468-8	2019	Moreover, the concentration of MCP-1, IFN-gamma, and IL-17A was reduced, and the content of IL-10 and TGF-beta1 was increased in the serum from SBP-treated mice.	sbp	144-147	mast cell protease 1	Mus musculus	31-36
30894457-7	2019	Inflammatory MCP-1 and fibrosis (collagen, fibronectin, plasminogen activator inhibitor-1, and osteopontin) renal biomarkers were significantly reduced in the CXA-10 (2.5 mpk) group.	10-nitro-oleic acid	159-165	mast cell protease 1	Mus musculus	13-18
30656591-7	2019	However, IL-6, MCP-1, and TNF-alpha production induced by Pam3CSK4 or lipid A was not augmented when cells were pretreated with curdlan, a dectin-1 ligand, or mannan, a dectin-2 ligand.	Lipid A	70-77	mast cell protease 1	Mus musculus	15-20
30905179-9	2019	Moreover, atorvastatin withdrawal induced shortly (ATW-3D) a peak in inflammatory markers (macrophages, MCP-1, tumor necrosis factor-alpha) and matrix metalloproteinases (MMP-3, MMP-9) concentrations within plaques, which sustained but to a lesser extent along time (ATW-7D, ATW-6W).	Atorvastatin	10-22	mast cell protease 1	Mus musculus	104-109
31242640-8	2019	DSS + MC-LR also resulted in greater increases in pro-inflammatory transcripts within colonic tissue (TNF-alpha, IL-1beta, CD40, MCP-1) and the pro-fibrotic marker, PAI-1, as compared to DSS-only ingestion.	Dextran Sulfate	0-3	mast cell protease 1	Mus musculus	129-134
31234344-4	2019	We found that DHA enclosed in RV-SLNs significantly enhanced its ability to contrast the cytotoxic effect of SDS and to inhibit the SDS- and TNF-alpha-induced production of the inflammatory cytokines IL-1beta, IL-6, and 1 MCP-1, in the two keratinocyte cell lines, as well as the NLRP3 inflammasome activation.	Docosahexaenoic Acids	14-17	mast cell protease 1	Mus musculus	222-227
31308853-7	2019	Autophagosomes secreted by FFCT-treated CT26.WT cells can activate M1 type macrophages, accompanied with increased expression of costimulatory molecules CD86 and CD40 on the surface of RAW264.7 cells, and more inflammatory cytokines secretion, such as TNF-alpha, IL-6, MCP-1, and IL-1beta.	ffct	27-31	mast cell protease 1	Mus musculus	269-274
30936017-5	2019	Distinctive stress responses resulting from doxorubicin treatment were observed, including upregulation of systemic markers of inflammation (IL-6, IL-1alpha, MCP-1), cardiac damage (ANP, BNP), DNA damage (i.e. DNA double-strand breaks (DSB)), DNA damage response (DDR) and cell death.	Doxorubicin	44-55	mast cell protease 1	Mus musculus	158-163
31359658-8	2019	Both of the in vitro and in vivo data consistently have confirmed that: by down-regulating the expression of MCP-1, LHWQ could efficiently decrease the chemotaxis of monocytes toward the pulmonary infection foci, thus blocking the disease development in ALI animal model.	lhwq	116-120	mast cell protease 1	Mus musculus	109-114
30099700-9	2019	Furthermore, we also found TLR4 deficiency abrogated CIH-induced macrophages (CD68) and fibroblasts (alpha-SMA) recruitment, further reducing expression of extra-cellular matrix protein (collagen I and collagen IV) and inflammatory cytokines release (IL-6, TNF-alpha, and MCP-1).	cih	53-56	mast cell protease 1	Mus musculus	272-277
31178953-8	2019	17-AAG counteracted IS-induced MCP1, TGF-beta, collagen I, and alpha-SMA expression and Smad2/3 phosphorylation.	tanespimycin	0-6	mast cell protease 1	Mus musculus	31-35
30848529-4	2019	This effect of BR was more prominent in contact co-culture of adipocytes and macrophages with a 90% and 34% reduction in IL-6 and MCP-1 levels, respectively.	brassinin	15-17	mast cell protease 1	Mus musculus	130-135
30848529-7	2019	However, knockdown of Nrf2 or HO-1 in RAW264.7 cells restored this BR-mediated inhibition of IL-6 and MCP-1 production.	brassinin	67-69	mast cell protease 1	Mus musculus	102-107
31057355-6	2019	Poly(I:C) increased the circulating levels of cytokines (TNF-alpha, MCP-1, IL-6, IL-10, IFN-alpha, IFN-gamma), an effect amplified by IF.	Poly I-C	0-8	mast cell protease 1	Mus musculus	68-73
31141554-11	2019	Colonic expression of iNOS, COX-2, TNF-alpha, and MCP-1 was decreased significantly in the apocynin treated group.	acetovanillone	91-99	mast cell protease 1	Mus musculus	50-55
31191309-10	2019	The percentage of M1-phenotype cells as well as the mRNA levels of iNOS, TNF-alpha, IL-1beta, and MCP-1 were downregulated when PF-treated polarized macrophages were cultured under conditions of high glucose (HG) levels.	peoniflorin	128-130	mast cell protease 1	Mus musculus	98-103
31134766-8	2019	Furthermore, less F4/80 positive cells, less activity of pathways related to the immune system and lower abundance of MCP1, MCP3, MCP5, and TARC in ligated bemcentinib-treated kidneys was compatible with reduction in inflammatory infiltrates by bemcentinib treatment.	bemcentinib	156-167	mast cell protease 1	Mus musculus	118-122
31073274-11	2019	Taken together, our results indicate that curcumin attenuated OVA-induced airway inflammation and mucus hypersecretion in mice and suppressed OVA- and IL-4-induced upregulation of MCP-1 and MUC5AC both in vivo and in vitro, most likely through a PPARgamma-dependent NF-kappaB signaling pathway.	Curcumin	42-50	mast cell protease 1	Mus musculus	180-185
30944389-9	2019	Furthermore, oral administration of GlcN reduced peritoneal neutrophils influx and lavage fluids concentrations of IL-1beta, IL-6 MCP-1 and TNF-alpha in uric acid crystal-injected mice.	Glucosamine	36-40	mast cell protease 1	Mus musculus	130-135
30343389-10	2019	TQ inhibited plasma cTnT levels; improved ATP; significantly inhibited p62, NLRP3, caspase-1, IL-1beta, IL-18, IL-6, TNF-alpha, and MCP-1expressions; and increased beclin 1 and IL-10 level.	thymoquinone	0-2	mast cell protease 1	Mus musculus	132-137
30721698-4	2019	Furthermore, PGG also inhibited TNF-alpha-induced expression of inflammatory cytokines including IL-6 and MCP-1 in the matured 3T3-L1 adipocytes.	pgg	13-16	mast cell protease 1	Mus musculus	106-111
31084401-6	2019	Neutrophil infiltration and IL-1beta & IL-6 & MCP-1 secretion was also alleviated in lavage fluids from DBA/1 mice with peritonitis due to Madecassoside treatment.	madecassoside	139-152	mast cell protease 1	Mus musculus	46-51
30804206-7	2019	Furthermore, palmitic acid (PA) treatment caused significant increase in Mcp-1, and decrease in both Pax2 and Ampk in murine renal mesangial cells (mRMCs) time- and dose-dependently.	Palmitic Acid	13-26	mast cell protease 1	Mus musculus	73-78
30804206-7	2019	Furthermore, palmitic acid (PA) treatment caused significant increase in Mcp-1, and decrease in both Pax2 and Ampk in murine renal mesangial cells (mRMCs) time- and dose-dependently.	Palmitic Acid	28-30	mast cell protease 1	Mus musculus	73-78
30804206-8	2019	Also, 14(15)-EET (a major substrate of sEH), but not its sEH-mediated metabolite 14,15-DHET, significantly reversed PA-induced increase in Mcp-1, and PA-induced decrease in Pax2 and Ampk.	Palmitic Acid	116-118	mast cell protease 1	Mus musculus	139-144
30596540-7	2019	RESULTS: Celastrol significantly inhibited LPS-induced expression of protein and mRNA expression levels encoding the proinflammatory cytokines, IL-6, IL-8, and MCP-1, in both HRPE and ARPE-19 cells.	celastrol	9-18	mast cell protease 1	Mus musculus	160-165
30062520-10	2019	Further in vivo study revealed that inhibition of MCP-1/CCR2 axis by Bindarit blocked the inhibitory effect of TIPE1 on osteosarcoma growth.	bindarit	69-77	mast cell protease 1	Mus musculus	50-55
30828084-10	2019	RESULTS The levels of serum IgE and IgG in BLA- or Dex- treated mice were significantly reduced compared to those in the asthma (AS) group (P&lt;0.01), whereas the levels of cytokines IL-4, TNF-alpha, and MCP-1 were significantly decreased (P&lt;0.01).	Dextromethorphan	51-54	mast cell protease 1	Mus musculus	205-210
30620923-5	2019	Treatment with WPI-EGCG, in turn, decreased the levels of IgG2a and mMCP-1 in serum of mice, possibly by the modulation of Th1/Th2 response and the increase of CD4+ Foxp3+ LAP- T and IL-17A+CD4+ T (Th17) cell populations.	epigallocatechin gallate	19-23	mast cell protease 1	Mus musculus	68-74
30896303-7	2019	Intracellular-free calcium level was measured by Fluorescent probe fluo-3/AM Results: SIN inhibited the production of TNF-alpha, MCP-1, MIF, and MMP-9, decreased the expression of CD14 and TLR4, and inhibited the release of intracellular-free calcium from intracellular stores in RAW 264.7 cells stimulated by LPS.	sinomenine	86-89	mast cell protease 1	Mus musculus	129-134
30890898-4	2019	The results demonstrate that melatonin inhibited the mRNA expression of TNF-alpha, IL-1beta, IL-6, CXCL1, MCP-1, and RANTES and the production of these cytokines and chemokines and IgG in LPS-stimulated mouse mammary tissue in vitro.	Melatonin	29-38	mast cell protease 1	Mus musculus	106-111
30718548-7	2019	In VTA, 3alpha,5alpha-THP (15 mg/kg, IP) administration reduced TRAF6 (~20%), CRF (~30%), and MCP-1 (~20%) levels, as well as TLR4 binding to GABAA receptor alpha2 subunits (~60%) and MyD88 (~40%).	pirarubicin	21-25	mast cell protease 1	Mus musculus	94-99
30180301-8	2019	In addition, ICAB inhibited hepatic stellate cells (HSCs) activation and the expressions of hepatic genes involved in liver fibrosis including LOX, TGF-beta1, MCP-1, COL1alpha1 and TIMP-1.	3,4-di-O-caffeoylquinic acid	13-17	mast cell protease 1	Mus musculus	159-164
30298517-10	2019	Pro-inflammatory cytokines including MCP-1, TNF-alpha, IL-1 and IL-6 were detected through RT-PCR and ELISA in experiment and GME can significantly inhibit the expression of TNF-alpha, IL-1 and IL-6 but have no effect on MCP-1.	gme	126-129	mast cell protease 1	Mus musculus	37-42
30298517-10	2019	Pro-inflammatory cytokines including MCP-1, TNF-alpha, IL-1 and IL-6 were detected through RT-PCR and ELISA in experiment and GME can significantly inhibit the expression of TNF-alpha, IL-1 and IL-6 but have no effect on MCP-1.	gme	126-129	mast cell protease 1	Mus musculus	221-226
30683148-0	2019	High dose gabapentin does not alter tumor growth in mice but reduces arginase activity and increases superoxide dismutase, IL-6 and MCP-1 levels in Ehrlich ascites.	Gabapentin	10-20	mast cell protease 1	Mus musculus	132-137
30391747-3	2019	In addition, PPARdelta agonist GW501516 enhanced pro-inflammatory gene expressions (COX-2, IL-6, IL-8 and MCP-1) in inflamed colon.	GW 501516	31-39	mast cell protease 1	Mus musculus	106-111
30713573-7	2019	Further studies indicated that SHL suppressed SP-elevated mouse mast cell protease-1 and IgE levels, prevented Th2 differentiation in mediastinal lymph nodes, and lowered Th2 cytokine (e.g., IL-4, IL-5, and IL-13) production in BALF.	sp	46-48	mast cell protease 1	Mus musculus	64-84
31933729-5	2019	After intrathecal injection of ZD-7288 and si-HCN2, both MWT and PWL were significantly increased, while the level of pro-inflammatory factors TNF-alpha, IL-1beta and MCP-1 were decreased in L4-L5 ipsilateral spinal dorsal horn.	ICI D2788	31-38	mast cell protease 1	Mus musculus	167-172
30687752-8	2018	Oridonin treatment significantly inhibited LPS-induced proinflammatory cytokines IL-1beta, IL-6, and MCP-1 production as well as cell adhesion molecules ICAM-1 and VCAM-1.	oridonin	0-8	mast cell protease 1	Mus musculus	101-106
30405619-7	2018	Both 1 w/w% and 2.5 w/w% GOS and/or budesonide suppressed serum mMCP-1 concentrations.	D-Glucitol-1,6-bisphosphate	25-28	mast cell protease 1	Mus musculus	64-70
30462474-8	2018	In terms of therapeutic applications, implant of scaffolds designed to release resveratrol into the visceral fat decreases MCP-1 expression in mice fed a high fat diet, a molecule that drives both local and systemic inflammation during obesity.	Resveratrol	79-90	mast cell protease 1	Mus musculus	123-128
30563142-4	2018	The results revealed that supplementation with LCBP decreased significantly the levels of IL-2, IL-6, MCP-1, and TNF-alpha in serum, as well as endotoxin levels in both serum and liver in HFD-fed mice.	lcbp	47-51	mast cell protease 1	Mus musculus	102-107
30277284-6	2018	In primary cultures, TMT induced significant neuronal death after 24-h intoxication and vigorous secretion of inflammatory cytokines (IL-1alpha/beta, IL-6, TNF-alpha, and MCP-1) in astrocytes.	trimethyltin	21-24	mast cell protease 1	Mus musculus	171-176
30103265-10	2018	In mice, EtOH increased hepatic TLR7 mRNA expression and enhanced imiquimod-induced expression of the pro-inflammatory mediators TNFalpha, MCP-1, and iNOS.	Ethanol	9-13	mast cell protease 1	Mus musculus	139-144
30666040-11	2018	Decrease in serum uric acid levels reduced GIS, AIS, MCP-1 expression and macrophages M1/M2 ratio (p&lt;0.05).	Uric Acid	18-27	mast cell protease 1	Mus musculus	53-58
30524645-9	2018	Serum level of mast cell protease 1 tended to be suppressed in FPP-consumed mice compared to those in saline-treated mice.	farnesyl pyrophosphate	63-66	mast cell protease 1	Mus musculus	15-35
30396035-12	2018	Meanwhile, curcumin significantly decreased the expression of multiple inflammatory cytokines (including mature IL-1beta, IL-6, MCP-1), MPO activity, caspase-1 activity as well as histopathological damage.	Curcumin	11-19	mast cell protease 1	Mus musculus	128-133
30466970-3	2018	HYPOTHESIS/PURPOSE: The sesquiterpene lactones (SLs) coronopilin and damsin, which are major secondary metabolites of A. arborescens, have anti-inflammatory activity by attenuation of IL-6 and MCP-1 expression and inhibition of NF-kappaB in human dermal fibroblasts (HDFa) and human keratinocytes (HaCaT).	Sesquiterpenes	24-37	mast cell protease 1	Mus musculus	193-198
30466970-3	2018	HYPOTHESIS/PURPOSE: The sesquiterpene lactones (SLs) coronopilin and damsin, which are major secondary metabolites of A. arborescens, have anti-inflammatory activity by attenuation of IL-6 and MCP-1 expression and inhibition of NF-kappaB in human dermal fibroblasts (HDFa) and human keratinocytes (HaCaT).	Lactones	38-46	mast cell protease 1	Mus musculus	193-198
30466970-3	2018	HYPOTHESIS/PURPOSE: The sesquiterpene lactones (SLs) coronopilin and damsin, which are major secondary metabolites of A. arborescens, have anti-inflammatory activity by attenuation of IL-6 and MCP-1 expression and inhibition of NF-kappaB in human dermal fibroblasts (HDFa) and human keratinocytes (HaCaT).	Sodium dodecyl sulfate	48-51	mast cell protease 1	Mus musculus	193-198
30466970-3	2018	HYPOTHESIS/PURPOSE: The sesquiterpene lactones (SLs) coronopilin and damsin, which are major secondary metabolites of A. arborescens, have anti-inflammatory activity by attenuation of IL-6 and MCP-1 expression and inhibition of NF-kappaB in human dermal fibroblasts (HDFa) and human keratinocytes (HaCaT).	coronopilin	53-64	mast cell protease 1	Mus musculus	193-198
30466970-17	2018	CONCLUSION: We show that coronopilin and damsin from A. arborescens inhibit pro-inflammatory IL-6 and MCP-1 expression in human skin cells via NF-kappaB inhibition, suggesting that they may be useful for antagonizing inflammatory conditions of the human skin.	coronopilin	25-36	mast cell protease 1	Mus musculus	102-107
30519584-6	2018	Further, treatment with CQ decreased the levels of active p65, TNF-alpha, MCP-1, and MMP-9 in cells underdesiccation stress.	Chloroquine	24-26	mast cell protease 1	Mus musculus	74-79
30405619-7	2018	Both 1 w/w% and 2.5 w/w% GOS and/or budesonide suppressed serum mMCP-1 concentrations.	Budesonide	36-46	mast cell protease 1	Mus musculus	64-70
29913301-17	2018	In vitro experimental results showed that RSF (25-100 mug/mL) could significantly inhibit the release of pro-inflammatory cytokines NO, TNF-alpha, IL-6 and MCP-1 on LPS-induced RAW264.7 cells.	(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol	42-45	mast cell protease 1	Mus musculus	156-161
30275707-7	2018	Meanwhile, the levels of TNF-alpha, IL-6, and MCP-1 in plasma were markedly suppressed in oldhamianoside-treated mice.	oldhamianoside	90-104	mast cell protease 1	Mus musculus	46-51
29656957-7	2018	PGA alone was sufficient to induce expression of TNF-alpha, IL-6, MCP-1, and MIP1-alpha, whereas MDP alone did not under the same conditions.	Folic Acid	0-3	mast cell protease 1	Mus musculus	66-71
30319187-10	2018	Conversely, cells were treated with citral significantly suppress the expression of PI3K/AKT, PPARgamma, SREBP-1c, FAS, CPD, TNF-alpha, IL-6 and MCP-1 in dose dependent manner.	citral	36-42	mast cell protease 1	Mus musculus	145-150
30340819-9	2018	Intake of glycine significantly inhibited allergy development in a concentration dependent manner as indicated by a reduction in; acute allergic skin response, anaphylaxis, serum mMCP-1 and serum levels of whey specific IgE.	Glycine	10-17	mast cell protease 1	Mus musculus	179-185
30298072-10	2018	Simvastatin induced a greater activation and proliferation of CD4+ T cells, as well as an increase in IL-6 and MCP-1 production, in chemotaxis to the peritoneum and in H2O2 secretion at this site.	Simvastatin	0-11	mast cell protease 1	Mus musculus	111-116
29380373-10	2018	Folic acid induced nephropathy was associated with the overexpression of inflammatory markers MCP-1, F4/80, type IV collagen, fibronectin and TGF-beta1 compared to control groups, which were partially attenuated by metformin treatment.	Folic Acid	0-10	mast cell protease 1	Mus musculus	94-99
29380373-10	2018	Folic acid induced nephropathy was associated with the overexpression of inflammatory markers MCP-1, F4/80, type IV collagen, fibronectin and TGF-beta1 compared to control groups, which were partially attenuated by metformin treatment.	Metformin	215-224	mast cell protease 1	Mus musculus	94-99
29723698-4	2018	The results showed that puerarin dose- and time-dependently reduced oxLDL-induced monocyte THP-1 adhesion to HUVECs and the expression of adhesion-related genes such as VCAM-1, ICAM-1, MCP-1 and IL-8 in HUVECs.	puerarin	24-32	mast cell protease 1	Mus musculus	185-190
29921037-6	2018	Meanwhile, H2 inhibited the overexpression of MCP-1, E-selectin, P-selectin and ICAM-1 in oxidant-induced endothelia and reduced inflammatory cells infiltration and proinflammatory cytokines (TNF-alpha, IL-1, IL-6 and IL-8) production in the wound.	Hydrogen	11-13	mast cell protease 1	Mus musculus	46-51
29678603-6	2018	Treatment with CA/CI/GA and the whole Triphala extract showed characteristic inhibition of MMP-9, cell proliferation/migration and tube formation as well the expression of IL-6, IL-8 and MCP-1 without affecting cell viability.	chebulinic acid	18-20	mast cell protease 1	Mus musculus	187-192
29678603-6	2018	Treatment with CA/CI/GA and the whole Triphala extract showed characteristic inhibition of MMP-9, cell proliferation/migration and tube formation as well the expression of IL-6, IL-8 and MCP-1 without affecting cell viability.	Gallic Acid	21-23	mast cell protease 1	Mus musculus	187-192
29787986-15	2018	We found that ASTF significantly inhibited the production of NO, PGE2, TNF-alpha, IL-6, MCP-1 and reactive oxygen species (ROS) in LPS-stimulated RAW 264.7 cells.	astf	14-18	mast cell protease 1	Mus musculus	88-93
29752681-5	2018	Further, differences in RANTES and MCP-1 secretion between C57BL/6J and Becn1+/- glia treated with Tat and morphine also suggest a role of Beclin1 in the morphine-induced enhancement.	Morphine	154-162	mast cell protease 1	Mus musculus	35-40
30187873-5	2018	RESULTS: DEX alleviated the inflammatory response and reduced the mRNA expressions of IL-6, TNF- a, MCP-1 andICAM-1 at 24 h after LPS injection.	Dexamethasone	9-12	mast cell protease 1	Mus musculus	100-115
29427351-6	2018	Acrolein-treated TM significantly decreased TM-specific immunoglobulin E/G1 levels, and histamine and mMCP-1 release in mouse serum.	Acrolein	0-8	mast cell protease 1	Mus musculus	102-108
29730778-8	2018	Thus, we showed that combined high glucose/high Fe alone or with MCM may contribute to an increase on intracellular iron and inflammatory response in 3T3-L1 differentiated cells, by increased mRNA levels of IL-6, TNF-alpha, MCP-1, Hpc and reducing adiponectin levels, enhancing the inflammatory processes.	Glucose	35-42	mast cell protease 1	Mus musculus	224-229
29730778-8	2018	Thus, we showed that combined high glucose/high Fe alone or with MCM may contribute to an increase on intracellular iron and inflammatory response in 3T3-L1 differentiated cells, by increased mRNA levels of IL-6, TNF-alpha, MCP-1, Hpc and reducing adiponectin levels, enhancing the inflammatory processes.	Iron	48-50	mast cell protease 1	Mus musculus	224-229
30049285-12	2018	CONCLUSIONS: Canagliflozin attenuates the progression of atherosclerosis, reducing (1) hyperlipidemia and hyperglycemia, and (2) inflammatory process, by lowering the expression of inflammatory molecules such as MCP-1 and VCAM-1.	Canagliflozin	13-26	mast cell protease 1	Mus musculus	212-217
30093945-7	2018	Following celastrol pretreatment, mice showed increased mortality rate and aggravated inflammation evidenced by further enhanced inflammatory markers of IL-6, IL-1beta, TNF-alpha, IL-18, MCP-1, and ICAM-1 in circulation, liver, and kidney after LPS treatment.	celastrol	10-19	mast cell protease 1	Mus musculus	187-192
29763604-7	2018	Since MCP1 and FetA drive macrophage to inflamed adipose tissue and IFNgamma promotes M2 to M1 transformation, both recruitment and M1 induced inflammation were found to be significantly repressed by dmp.	Unithiol	200-203	mast cell protease 1	Mus musculus	6-10
29763604-8	2018	In addressing the question about how dmp induced excess SIRT1 could reduce MCP1, FetA and IFNgamma levels, we found that it was due to the inactivation of NFkappaB because of its deacetylation by SIRT1.	Unithiol	37-40	mast cell protease 1	Mus musculus	75-79
30034291-7	2018	Treatment with aspirin inhibited 4T1 cell growth and migration and MCP-1, PAI-1, and IL-6 production.	Aspirin	15-22	mast cell protease 1	Mus musculus	67-72
30034291-8	2018	In the coculture of both cells, aspirin inhibited secretion of MCP-1, IL-6, and TGF-beta.	Aspirin	32-39	mast cell protease 1	Mus musculus	63-68
29669585-10	2018	Antibody array analysis showed that 4-PBA reduced several angiogenic factors [Granulocyte Macrophage Colony Stimulating Factor (GM-CSF), MCP-1, IL-6] secreted by PVAT.	4-phenylbutyric acid	36-41	mast cell protease 1	Mus musculus	137-142
29701676-5	2018	Baicalein at concentrations up to 100 &amp;mu;M significantly inhibited the production of NO, IL-1&amp;alpha;, IL-6, G-CSF, GM-CSF, VEGF, MCP-1, IP-10, LIX, and RANTES as well as calcium release in RAW 264.7 cells induced by poly I:C (50 &amp;micro;g/mL) (all p &lt; 0.05).	baicalein	0-9	mast cell protease 1	Mus musculus	138-143
29319896-10	2018	MC903 treatment increased serum baseline and postchallenge mmcp1 levels.	calcipotriene	0-5	mast cell protease 1	Mus musculus	59-64
29726680-11	2018	The three most potent stilbenoids, piceatannol, pinosylvin, and pterostilbene, were selected for in vivo testing and were found to suppress inflammatory edema and to down-regulate the production of inflammatory mediators IL6 and MCP1 in carrageenan-induced paw inflammation in mice.	stilbenoids	22-33	mast cell protease 1	Mus musculus	229-233
29726680-11	2018	The three most potent stilbenoids, piceatannol, pinosylvin, and pterostilbene, were selected for in vivo testing and were found to suppress inflammatory edema and to down-regulate the production of inflammatory mediators IL6 and MCP1 in carrageenan-induced paw inflammation in mice.	3,3',4,5'-tetrahydroxystilbene	35-46	mast cell protease 1	Mus musculus	229-233
29726680-11	2018	The three most potent stilbenoids, piceatannol, pinosylvin, and pterostilbene, were selected for in vivo testing and were found to suppress inflammatory edema and to down-regulate the production of inflammatory mediators IL6 and MCP1 in carrageenan-induced paw inflammation in mice.	pinosylvin	48-58	mast cell protease 1	Mus musculus	229-233
29726680-11	2018	The three most potent stilbenoids, piceatannol, pinosylvin, and pterostilbene, were selected for in vivo testing and were found to suppress inflammatory edema and to down-regulate the production of inflammatory mediators IL6 and MCP1 in carrageenan-induced paw inflammation in mice.	pterostilbene	64-77	mast cell protease 1	Mus musculus	229-233
29494957-10	2018	PAG also reduced serum concentrations of type 2 helper T cell (Th2) cytokines (Interleukin-(IL)-4, IL-5, and IL-13) as well as histamine, mast cell protease-1 (MCP-1), and immunoglobulin (Ig)E. PAG blocked the degranulation of mast cells and infiltration of eosinophils in intestine.	pag	0-3	mast cell protease 1	Mus musculus	138-158
29494957-10	2018	PAG also reduced serum concentrations of type 2 helper T cell (Th2) cytokines (Interleukin-(IL)-4, IL-5, and IL-13) as well as histamine, mast cell protease-1 (MCP-1), and immunoglobulin (Ig)E. PAG blocked the degranulation of mast cells and infiltration of eosinophils in intestine.	pag	0-3	mast cell protease 1	Mus musculus	160-165
29351316-12	2018	The mRNA expression of TNF-alpha, MCP-1, indoleamine 2, 3 dioxygenase (IDO), caspase-3, and iNOS were increased in the brain of LPS-challenged mice, which were reduced by Dex but not vehicle.	Dexmedetomidine	171-174	mast cell protease 1	Mus musculus	34-69
29501084-7	2018	Consistently, SR141716A promoted BV-2 microglia to release inflammatory factors (TNF-alpha, IL-1beta, IL-6) while inhibited the production of IL-10 and chemokines (MCP-1, CX3CL1).	Rimonabant	14-23	mast cell protease 1	Mus musculus	164-169
29642385-8	2018	Two-month exposure to the high dose of CS significantly increased the plaque area in aortic arch, and significantly upregulated the expression of atherosclerotic markers (VCAM-1, ICAM-1, MCP1, p22phox, and gp91phox).	Cesium	39-41	mast cell protease 1	Mus musculus	187-191
29534036-2	2018	BaP enhanced the INFG, especially MCP-1 and TNFalpha.	Benzo(a)pyrene	0-3	mast cell protease 1	Mus musculus	34-39
29534036-4	2018	Treatment with BaP and PCBs during only the maturation period up-regulated the INFG (IL6, TNFalpha, CXCL-10 &amp;amp; MCP-1).	Benzo(a)pyrene	15-18	mast cell protease 1	Mus musculus	118-123
29534036-4	2018	Treatment with BaP and PCBs during only the maturation period up-regulated the INFG (IL6, TNFalpha, CXCL-10 &amp;amp; MCP-1).	Polychlorinated Biphenyls	23-27	mast cell protease 1	Mus musculus	118-123
28969938-8	2018	RESULTS: In mice treated with high-dose GW0742, plasma levels of IL-6, IL-1beta, and MCP-1 were significantly increased compared to the control group mice.	GW0742	40-46	mast cell protease 1	Mus musculus	85-90
28969938-9	2018	When compared to mice treated with low-dose GW0742 plasma levels of IL-6, IL-1beta, GM-CSF, KC, and MCP-1 were significantly elevated in high-dose-treated mice.	GW0742	44-50	mast cell protease 1	Mus musculus	100-105
29328946-5	2018	The results showed that kaempferol reduced the production of various pro-inflammatory factors and inflammatory proteins including IL-1beta, IL-6, TNF-alpha, MCP-1, COX-2 and iNOS in brain tissues.	kaempferol	24-34	mast cell protease 1	Mus musculus	157-162
28935544-10	2018	In vivo, we discovered that metformin not only decreased the serum level of the pro-inflammatory cytokines IL-6 and TNF-alpha but also lowered the expression of the M1 macrophage markers CD11c and MCP-1 in adipose tissue.	Metformin	28-37	mast cell protease 1	Mus musculus	197-202
29127663-7	2018	Consistent with this, inflammatory cytokines including TNFalpha, IL-12p40, IFNgamma, and MCP-1 were enhanced both systemically and locally in the poly(I:C)-treated group compared to the vehicle control.	poly	146-150	mast cell protease 1	Mus musculus	89-94
29592806-10	2018	We showed that BAIBA treatment stimulated AMP-activated protein kinase (AMPK) phosphorylation in a dose-dependent manner and lipopolysaccharide (LPS)-induced secretion of pro-inflammatory cytokines such as TNFalpha and MCP-1 was abrogated in BAIBA-treated 3 T3-L1 cells.	3-aminoisobutyric acid	15-20	mast cell protease 1	Mus musculus	219-224
29541444-4	2018	We found that, in PSGL-1+/+ mice, high salt diet resulted in high blood pressure with the increased expression of serum inflammatory cytokines IL-6, IL-1beta and TNFalpha, vascular injury markers MCP-1, ET-1, and VWF, and renal macrophages and T cells infiltration, and endothelium-dependent acetylcholine vasodilation dysfunction.	Salts	39-43	mast cell protease 1	Mus musculus	196-201
29275496-7	2018	Lastly, DD-treated mice were protected against LPS-induced acute liver injury, based on morphologic and immunohistochemical observations; reduction in the plasma levels of aspartate aminotransferase, TNF-alpha, and MCP-1; and a decrease in inflammatory gene expression.	dd	8-10	mast cell protease 1	Mus musculus	215-220
29234949-3	2018	Curc-mPEG454 showed lower cytotoxicity (IC50 57.8 muM) when compared with that of curcumin (IC50 32.6 muM) and inhibited the release of the inflammatory cytokines IL-6, TNF-alpha, IL-1beta, and MCP-1 in a concentration-dependent manner.	curc-mpeg454	0-12	mast cell protease 1	Mus musculus	194-199
29280507-4	2018	The results showed that injection of SO-GS-R significantly increased the levels of IL-1beta, IL-5, IL-6, G-CSF, KC, MCP-1, MIP-1alpha, and MIP-1beta in both serum and muscle.	sulfur monoxide	37-39	mast cell protease 1	Mus musculus	116-121
28670854-8	2018	Honokiol decreased M1 marker genes (TNFalpha and MCP-1) and increased M2 marker gene (YM-1, IL-10, IL-4R and IL-13) expression in mice liver compared with CL diet.	honokiol	0-8	mast cell protease 1	Mus musculus	49-54
29742501-4	2018	Furthermore, we also examined the effect of histamine on the secretion of MCP-1 and IL-13 from mast cells by ELISA.	Histamine	44-53	mast cell protease 1	Mus musculus	74-79
27867196-6	2018	Consistent with this, ADP and ADP-treated cell culture medium attracted more macrophages in the transwell assay by enhancing the expression of MCP-1.	Adenosine Diphosphate	22-25	mast cell protease 1	Mus musculus	143-148
27867196-6	2018	Consistent with this, ADP and ADP-treated cell culture medium attracted more macrophages in the transwell assay by enhancing the expression of MCP-1.	Adenosine Diphosphate	30-33	mast cell protease 1	Mus musculus	143-148
27867196-10	2018	Accordingly, ADP-induced MCP-1 production and protection against bacterial infection could also be reduced by U0126, forskolin and 8-bromo-cAMP.	Adenosine Diphosphate	13-16	mast cell protease 1	Mus musculus	25-30
27867196-10	2018	Accordingly, ADP-induced MCP-1 production and protection against bacterial infection could also be reduced by U0126, forskolin and 8-bromo-cAMP.	U 0126	110-115	mast cell protease 1	Mus musculus	25-30
27867196-10	2018	Accordingly, ADP-induced MCP-1 production and protection against bacterial infection could also be reduced by U0126, forskolin and 8-bromo-cAMP.	Colforsin	117-126	mast cell protease 1	Mus musculus	25-30
27867196-10	2018	Accordingly, ADP-induced MCP-1 production and protection against bacterial infection could also be reduced by U0126, forskolin and 8-bromo-cAMP.	8-Bromo Cyclic Adenosine Monophosphate	131-143	mast cell protease 1	Mus musculus	25-30
30257239-10	2018	A reduction of inflammatory cell infiltration and inflammatory cytokine mRNA expression (iNOS, NF-kappaB, MCP-1, and TNF-alpha) following the administration of FF (50 mg/kg) was observed in LPS-treated renal tissue.	Phenylalanylphenylalanine	160-162	mast cell protease 1	Mus musculus	106-111
29742501-5	2018	RESULTS: The amplification of TLR3 mRNA and protein expression in mast cells was observed after incubation with histamine, which was accompanied by increasing secretion of IL-13 and MCP-1 via H1 receptor.	Histamine	112-121	mast cell protease 1	Mus musculus	182-187
29742501-7	2018	CONCLUSION: These results demonstrate that histamine up-regulates the expression of TLR3 and secretion of IL-13 and MCP-1 in mast cells, thus identifying a new mechanism for the histamine inducing allergic response.	Histamine	43-52	mast cell protease 1	Mus musculus	116-121
29742501-7	2018	CONCLUSION: These results demonstrate that histamine up-regulates the expression of TLR3 and secretion of IL-13 and MCP-1 in mast cells, thus identifying a new mechanism for the histamine inducing allergic response.	Histamine	178-187	mast cell protease 1	Mus musculus	116-121
28624598-8	2017	This in turn led to the blockade of iNOS and COX-2, thereby inhibiting the production of nitric oxide and pro inflammatory cytokines such as TNF-alpha, IL-6, MCP-1 and IL-1beta.	Nitric Oxide	89-101	mast cell protease 1	Mus musculus	158-163
28744946-8	2017	In addition, these TPM treated mice, also showed a marked reduction in aortic superoxide formation and decreased circulating plasma levels of known pro-inflammatory markers IL-6, MCP-1, IL-1beta, IFN-gamma and TNF-alpha.	Topiramate	19-22	mast cell protease 1	Mus musculus	179-184
28550659-7	2017	In mice ventilated for 12 h, a significant increase in TNF-alpha, IFN-gamma, IL-1beta, IL-10, and MCP-1 (P &lt; 0.01) was observed with 90% FiO2, whereas IL-6 showed a decreasing trend (P for trend = 0.03) across FiO2 groups.	fio2	140-144	mast cell protease 1	Mus musculus	98-103
29056914-11	2017	Histopathological and hepatic damage (Cyp2e1, Caspase3, alphaSma, Tnfalpha, and Mcp1)-related alterations observed after repeated APAP administration were aggravated in the liver of Pparalpha-deficient mice.	Acetaminophen	130-134	mast cell protease 1	Mus musculus	80-84
28608568-8	2018	Furthermore, pretreatment of RAW264.7 cells with HSP70 antibodies reduced pCry1Ac-induced ERK1 phosphorylation and MCP-1 production; thus suggest the functional participation of csHSP70 in pCry1Ac-induced macrophage activation.	pcry1ac	74-81	mast cell protease 1	Mus musculus	115-120
29158052-10	2018	BA treatment dramatically suppressed MCD diet-induced hepatic inflammation, which was associated with decrease in serum TNF-alpha, IL-1beta and MCP-1 production, macrophage influx and suppression of nuclear factor-kappaB activation.	baicalin	0-2	mast cell protease 1	Mus musculus	144-149
29180336-8	2017	The expression levels of Ucp1 mRNA and protein increased (P&lt;0.05) and the expressions of Mcp1 and TNF-alpha decreased significantly in the mice after rutin treatment (P&lt;0.05).	Rutin	153-158	mast cell protease 1	Mus musculus	92-96
28843991-5	2017	Acute oral administration of NaAsO2 also raised pulmonary MPO activity and mRNA levels of chemokine Mip-2 and Mcp-1.	sodium arsenite	29-35	mast cell protease 1	Mus musculus	110-115
28347868-5	2017	Histological analyses demonstrated that teneligliptin decreased lipid deposition and MCP-1 expression (P&lt;0.05, respectively), and tended to decrease macrophage accumulation in atherosclerotic plaques.	3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine	40-53	mast cell protease 1	Mus musculus	85-90
28342364-9	2017	The reduced severity of the disease in animals treated with quercetin was associated with decreased levels of TNF-alpha, IL-1beta, IL-17, and MCP-1.	Quercetin	60-69	mast cell protease 1	Mus musculus	142-147
28603288-8	2017	Moreover, in LPS-stimulated mouse peritoneal macrophages, SB203580 strongly inhibited the restored expression of IL-1beta, IL-6, COX2, and MCP-1, which was achieved by abolishing the suppressive effects of osthole with the PKA inhibitors.	SB 203580	58-66	mast cell protease 1	Mus musculus	139-144
28552635-6	2017	The levels of cytokine production in non-infected mice revealed that GA-treated and TA-treated mice elicited an increased level of IFN-gamma, and both IFN-gamma and MCP-1, respectively, as compared with the PBS-treated group.	Gallic Acid	69-71	mast cell protease 1	Mus musculus	165-170
28525841-5	2017	Similar to LL-37, KR-12-a5 and its analogs significantly inhibited the expression and secretion of NO, TNF-alpha, IL-6 and MCP-1 from LPS-stimulated RAW264.7 cells.	Krypton	18-20	mast cell protease 1	Mus musculus	123-128
28603288-6	2017	In mouse peritoneal macrophages, pretreatment with osthole (50 mumol/L) significantly attenuated the LPS-induced elevation of cytokines at the mRNA level; inhibition of PKA completely reversed the inhibitory effects of osthole on IL-1beta, IL-6, COX2, and MCP-1 but not on TNFalpha.	osthol	51-58	mast cell protease 1	Mus musculus	256-261
28131916-5	2017	The mitochondria-targeted antioxidant plastoquinonyl decyltriphenylphosphonium (SkQ1) which also catalyzes FFA-dependent uncoupling revealed similar protective effects and downregulated expression of the NFkappaB-regulated genes (VCAM1, ICAM1, MCP1, and IL-6) involved in the inflammatory response of endothelium in aortas of the TNF-treated mice.	decyltriphenylphosphonium	53-78	mast cell protease 1	Mus musculus	244-248
28315617-7	2017	Compared with their respective pair-fed controls, all ethanol-fed mice exhibited elevated levels of serum ALT; the inflammatory cytokines TNF-alpha, MCP-1 and MIP-2; hepatic lipid peroxides and triglycerides.	Ethanol	54-61	mast cell protease 1	Mus musculus	149-154
28359154-5	2017	The results of in vivo assay showed that ESO decreased the levels of mast cell protease-1 and histamine and inhibited the levels of specific IgE by 77.7%.	Epoxidized soya bean oil	41-44	mast cell protease 1	Mus musculus	69-89
27585667-8	2017	In vivo and in vitro CsA promoted secretion of the TLR ligand HMGB1 by tubular cells upstream of TLR4 activation, and prevention of HMGB1 secretion significantly reduced CsA-induced synthesis of MCP-1, suggesting that HMGB1 may be one of the mediators of CsA-induced TLR4 activation.	Cyclosporine	170-173	mast cell protease 1	Mus musculus	195-200
27585667-8	2017	In vivo and in vitro CsA promoted secretion of the TLR ligand HMGB1 by tubular cells upstream of TLR4 activation, and prevention of HMGB1 secretion significantly reduced CsA-induced synthesis of MCP-1, suggesting that HMGB1 may be one of the mediators of CsA-induced TLR4 activation.	Cyclosporine	170-173	mast cell protease 1	Mus musculus	195-200
27997528-9	2017	Serum levels of IL-6, TNF-alpha, MCP-1, and IL-10 after Lactobacillus casei cell wall extract injection were slightly decreased by IVIG or losartan.	Losartan	139-147	mast cell protease 1	Mus musculus	33-38
27965141-7	2017	Real time polymerase chain reaction assay indicated that administration of PG after SCI down-regulated the expression of pro-inflammatory cytokines MCP-1, NOS2, and IL-1beta (P &lt; 0.05).	Progesterone	75-77	mast cell protease 1	Mus musculus	148-153
27997528-10	2017	Moreover, IL-1beta, IL-10, and MCP-1 levels were significantly decreased by IVIG+losartan.	Losartan	81-89	mast cell protease 1	Mus musculus	31-36
28160073-7	2017	The activity of NF-kappaB signaling declined sharply after the treatment with genistein, as evidenced by the inhibition of NF-kappaB-p65, phospho-NF-kappaB-p65, and phospo-IkappaB-alpha expressions, as well as the expression of IkappaB-alpha and the messenger RNA (mRNA) expression of inflammatory cytokines (MCP1, TNFalpha, IL1beta, IL4, IL10) mediated by NF-kappaB signaling pathways in the early phase of the infection.	Genistein	78-87	mast cell protease 1	Mus musculus	309-313
28160073-10	2017	These results provided evidence that genistein reduces S. japonicum egg-induced liver granuloma and fibrosis, at least partly due to decreased NF-kappaB signaling, and subsequently decreased MCP1, TNFalpha, and IL10 expressions.	Genistein	37-46	mast cell protease 1	Mus musculus	191-195
28400700-8	2017	The p38 inhibitor (SB203580) attenuated RBP4-stimulated vascular cell adhesion molecule 1 (VCAM-1), intracellular adhesion molecule 1 (ICAM-1), monocyte chemoattractant protein (MCP-1), and interleukin 6 (IL-6) production, while the JNK inhibitor (SP600125) reduced RBP4-stimulated sICAM-1, endothelial cell selectin (E-selectin), and MCP-1 production.	SB 203580	19-27	mast cell protease 1	Mus musculus	178-183
27648694-8	2017	Strikingly, CLP mice treated with GdCl3 were protected against liver injury as evidenced by decreased LSECs defenestration and damage, MPO, ALT and AST activities, liver tissue damage, and inflammatory cytokines TNF-alpha, IL-6 and IL-1beta, and chemokines MCP-1 and MIP-2alpha.	gadolinium chloride	34-39	mast cell protease 1	Mus musculus	257-262
28400700-8	2017	The p38 inhibitor (SB203580) attenuated RBP4-stimulated vascular cell adhesion molecule 1 (VCAM-1), intracellular adhesion molecule 1 (ICAM-1), monocyte chemoattractant protein (MCP-1), and interleukin 6 (IL-6) production, while the JNK inhibitor (SP600125) reduced RBP4-stimulated sICAM-1, endothelial cell selectin (E-selectin), and MCP-1 production.	SB 203580	19-27	mast cell protease 1	Mus musculus	335-340
28356707-9	2017	While NMDA treatment dramatically upregulated mRNAs of inflammatory cytokines (TNFalpha, IL-1beta, MCP-1, RANTES) in retinal homogenates, co-injection with JQ1 suppressed their upregulation by ~50%.	N-Methylaspartate	6-10	mast cell protease 1	Mus musculus	99-104
27817102-10	2017	Of note, the expression of p-Akt increased by curcumin was accompanied by the decreased chemokines MCP-1 and MIP-1 levels and fewer CD68-positive macrophages in the placenta.	Curcumin	46-54	mast cell protease 1	Mus musculus	99-104
28190475-10	2017	RESULTS: Calycosin significantly inhibited body weight loss induced by MCD diet, decreased the ALT and AST activities, MCP-1 and mKC in a dose-dependent manner.	7,3'-dihydroxy-4'-methoxyisoflavone	9-18	mast cell protease 1	Mus musculus	119-124
27692982-4	2017	Although rapamycin did not affect the increase in body weight and adiposity, it exacerbated the glucose intolerance and adipose tissue inflammation induced by HFD feeding, as evidenced by the increased adipose tissue percentage of M1 macrophages, naive and activated cytotoxic T lymphocytes, and mRNA levels of proinflammatory molecules, such as TNF-alpha, IL-6 and MCP-1.	Sirolimus	9-18	mast cell protease 1	Mus musculus	366-371
28202417-7	2017	Triptolide treatment attenuated TAC-induced myocardial remodeling, improved cardiac diastolic and systolic function, inhibited the NLRP3 inflammasome and downstream inflammatory mediators (IL-1beta, IL-18, MCP-1, VCAM-1), activated the profibrotic TGF-beta1 pathway, and suppressed macrophage infiltration in a dose-dependent manner.	triptolide	0-10	mast cell protease 1	Mus musculus	206-211
28259175-9	2017	The levels of TNF-alpha, IL-6, and MCP-1 in response to LPS were significantly increased in the PFC of PTN-Tg mice compared to that of WT mice.	Thioguanine	107-109	mast cell protease 1	Mus musculus	35-40
28228829-10	2017	Hepatic Mcp-1 and Tnf-alpha mRNA levels were significantly lower in the CR compared with the HFD (74 and 47% lower) and showed significantly negative correlations with hepatic non-heme iron levels (Mcp-1: r = -0.557, P &lt; 0.05; Tnf-alpha: r = -0.464, P &lt; 0.05).	Iron	185-189	mast cell protease 1	Mus musculus	8-13
28064485-5	2017	OVA induced mouse pulmonary MCP-1, and H2O2 enhanced the expression of MCP-1/ICAM-1/alphav integrin in bronchial airway epithelial BEAS-2B cells.	Hydrogen Peroxide	39-43	mast cell protease 1	Mus musculus	71-76
28000518-7	2017	Furthermore, pretreatment of cells with artemisinin prevented the TNF-alpha-induced expression of NF-kappaB target genes, such as anti-apoptosis (c-IAP1, Bcl-2, and FLIP), proliferation (COX-2, cyclinD1), invasion (MMP-9), angiogenesis (VEGF), and major inflammatory cytokines (TNF-alpha, iNOS, and MCP1).	artemisinin	40-51	mast cell protease 1	Mus musculus	299-303
28017899-7	2017	For the in vivo tests, nocodazole -treated mice displayed elevated levels of IFN-gamma, MCP-1 and IL-10 while Brucella-infected nocodazole -treated mice showed high levels of TNF, IFN-gamma, MCP-1, IL-10 and IL-6 as compared to controls.	Nocodazole	128-138	mast cell protease 1	Mus musculus	191-196
28104981-7	2017	Endotoxin-associated genes such as TLR4 and Myd88, pro-inflammation genes such as MCP-1, TNF-alpha, IL-1, IL-2, IL-6 and IFN-gamma in liver or epididymal fat were obviously downregulated after NaB intervention.	nab	193-196	mast cell protease 1	Mus musculus	82-87
27525508-7	2017	Furthermore, alpha,beta-amyrin decreased serum TNF-alpha and MCP-1.	alpha,beta-amyrin	13-30	mast cell protease 1	Mus musculus	61-66
27393133-6	2017	Bilirubin supplementation of islet media also decreased the release of DAMPs (HMGB1), inflammatory cytokines (IL-1beta and IL-6), and chemokines (MCP-1).	Bilirubin	0-9	mast cell protease 1	Mus musculus	146-151
28017899-7	2017	For the in vivo tests, nocodazole -treated mice displayed elevated levels of IFN-gamma, MCP-1 and IL-10 while Brucella-infected nocodazole -treated mice showed high levels of TNF, IFN-gamma, MCP-1, IL-10 and IL-6 as compared to controls.	Nocodazole	23-33	mast cell protease 1	Mus musculus	88-93
27902475-8	2017	Furthermore, osthole can suppress NF-kappaB signal pathway through the inhibition of the nuclear translocation by regulating phosphorylation of IkappaBalpha and IKKbeta and hinder the production of chemoattractant (MCP-1 and IL-8) and proinflammatory cytokines (TNF-alpha, IL-1beta and IL-6).	osthol	13-20	mast cell protease 1	Mus musculus	215-220
28056291-8	2017	Conclusions: Treatment with testosterone in adult fe-male mice can induce insulin resistance by blocking insulin signal transduction, without in-fluencing body weight and body fat content.Testosterone could activate the NF-kappaB to pro-mote the expression of IL-6 and MCP-1.	Testosterone	28-40	mast cell protease 1	Mus musculus	269-274
28056291-6	2017	And more obvious significance was detected at 16 weeks treat-ment (P&lt;0.01); (4) 16 weeks treatment with testosterone induced the increase of AUC of the blood glucose following ITT(P&lt;0.01); (5) the serum IL-6 and MCP-1 in testosterone treat-ment was higher than that in thecontrols (P&lt;0.05).	Testosterone	107-119	mast cell protease 1	Mus musculus	218-223
28056291-8	2017	Conclusions: Treatment with testosterone in adult fe-male mice can induce insulin resistance by blocking insulin signal transduction, without in-fluencing body weight and body fat content.Testosterone could activate the NF-kappaB to pro-mote the expression of IL-6 and MCP-1.	Testosterone	188-200	mast cell protease 1	Mus musculus	269-274
29348704-8	2017	Furthermore, nicotine-induced secretions of MMP-2, MMP-9, MCP-1, and RANTES were remarkably downregulated.	Nicotine	13-21	mast cell protease 1	Mus musculus	58-63
28503033-8	2017	Inflammation, measured by nuclear NF-kappaB, F4/80, and MCP-1, was increased in response to UUO and further increased by 15d-PGJ2.	15-deoxy-delta(12,14)-prostaglandin J2	121-129	mast cell protease 1	Mus musculus	56-61
29132134-11	2017	Proinflammatory markers MCP-1, TNF-alpha, CXCL11, IL-6, and CD68 were significantly increased in the intestinal epithelia in CCI4-treated mice.	cci4	125-129	mast cell protease 1	Mus musculus	24-29
29348704-0	2017	Stimulation of Alpha7 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Upregulation of MMP, MCP-1, and RANTES through Modulating ERK1/2/AP-1 Signaling Pathway in RAW264.7 and MOVAS Cells.	Nicotine	66-74	mast cell protease 1	Mus musculus	104-109
29348704-5	2017	Pretreatment with U0126 significantly suppressed phosphorylation of ERK1/2 and further attenuated nicotine-induced activation of c-Jun and upregulation of MMP-2, MMP-9, monocyte chemotactic protein- (MCP-) 1, and regulated upon activation normal T cell expressed and secreted (RANTES).	U 0126	18-23	mast cell protease 1	Mus musculus	169-207
28951767-6	2017	Baicalin attenuated ethanol-induced proinflammatory molecules such as TNF-alpha, IL-1beta, MIP-2, and MCP-1 and reversed redox-sensitive transcription factor NF-kappaB activation.	baicalin	0-8	mast cell protease 1	Mus musculus	102-107
29348704-5	2017	Pretreatment with U0126 significantly suppressed phosphorylation of ERK1/2 and further attenuated nicotine-induced activation of c-Jun and upregulation of MMP-2, MMP-9, monocyte chemotactic protein- (MCP-) 1, and regulated upon activation normal T cell expressed and secreted (RANTES).	Nicotine	98-106	mast cell protease 1	Mus musculus	169-207
29348704-6	2017	Similarly, nicotine treatment also increased phosphorylation of c-Jun and expressions of MMP-2, MMP-9, MCP-1, and RANTES in MOVAS cells.	Nicotine	11-19	mast cell protease 1	Mus musculus	103-108
28751937-4	2017	Myricitrin also markedly suppressed the production of NO, TNF-alpha, IL-6, and MCP-1 in RAW264.7 macrophage cells.	myricitrin	0-10	mast cell protease 1	Mus musculus	79-84
28951767-6	2017	Baicalin attenuated ethanol-induced proinflammatory molecules such as TNF-alpha, IL-1beta, MIP-2, and MCP-1 and reversed redox-sensitive transcription factor NF-kappaB activation.	Ethanol	20-27	mast cell protease 1	Mus musculus	102-107
27702567-9	2016	In addition, berberine reduced the elevated levels of serum TNF-alpha, IL-6 and MCP-1 and the expressions of TNF-alpha, IL-6 and MCP-1 and attenuated the phosphorylation of JNK and IKKbeta and the expression of NF-kappaB p65 in the obese adipose tissue, Raw264.7 macrophages and 3T3-L1 adipocytes, respectively.	Berberine	13-22	mast cell protease 1	Mus musculus	80-85
27702567-9	2016	In addition, berberine reduced the elevated levels of serum TNF-alpha, IL-6 and MCP-1 and the expressions of TNF-alpha, IL-6 and MCP-1 and attenuated the phosphorylation of JNK and IKKbeta and the expression of NF-kappaB p65 in the obese adipose tissue, Raw264.7 macrophages and 3T3-L1 adipocytes, respectively.	Berberine	13-22	mast cell protease 1	Mus musculus	129-134
27747335-3	2016	The STZ-treated C57BL/6J diabetic mice developed progressive albuminuria and renal tubular interstitial fibrosis within 10 weeks, accompanied by increased production of ANG II, fibronection, TGF-beta, CTGF, TNF-alpha, RANTES and MCP-1 and decreased expression of slit diaphragm proteins in the kidney.	Streptozocin	4-7	mast cell protease 1	Mus musculus	229-234
27909560-9	2016	In co-cultures of lipid-laden hepatocytes and macrophages, treatment with quercetin induced HO-1 in the macrophages, markedly suppressed expression of M1 macrophage marker genes, and reduced release of MCP-1.	Quercetin	74-83	mast cell protease 1	Mus musculus	202-207
27777976-4	2016	Blocking MCP-1/CCR2 signaling in HPS mice with genetic deficiency of CCR2 or targeted deletion of MCP-1 in AECs normalized macrophage recruitment, decreased AEC apoptosis, and reduced lung fibrosis in these mice following treatment with low-dose bleomycin.	Bleomycin	246-255	mast cell protease 1	Mus musculus	9-14
27764743-6	2016	In vivo, the results showed that oroxylin A dose-dependently attenuated CS-induced lung histopathologic changes, expression of cytokines TNF-alpha, IL-1beta, and MCP-1, and levels of oxidative biomarkers 3-nitrotyrosine and 8-isoprostane.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	33-41	mast cell protease 1	Mus musculus	162-167
26624246-9	2016	Interestingly, while the ERK1/2 inhibitor PD98059 abolished the elevations in MCP-1 expression and cell proliferation, the ERK5 inhibitor BIX02189 abrogated the elevation in collagen type 1 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	42-49	mast cell protease 1	Mus musculus	78-83
27754445-5	2016	In-vivo experiments indicated that mice treated with P-Asp had less distinct allergenic responses than other bacterial enzyme preparations as indicated by lower serum concentrations of IgG, IgE, IgM and mMCP-1 compared with other treated groups.	4-S-(propionic acid)sulfidocyclophosphamide	53-58	mast cell protease 1	Mus musculus	203-209
27316397-5	2016	Furthermore, artesunate could down-regulate the pro-inflammatory chemokines such as IL-8 and MCP-1 in aorta of mice.	Artesunate	13-23	mast cell protease 1	Mus musculus	93-98
27316397-6	2016	Besides, artesunate didn"t influence IL-8 and MCP-1 secretion in HUVECs up-regulated by TNF-alpha, but inhibited IL-8 and MCP-1 secretion up-regulated by LPS.	Artesunate	9-19	mast cell protease 1	Mus musculus	122-127
27316397-7	2016	CONCLUSION: AS attenuated progression of atherosclerosis lesion formation alone or combined with rosuvastatin through anti-inflammatory effect, resulting in down-regulation of TNF-alpha and IL-6, and further down-regulating IL-8 and MCP-1 expressions in aorta of WD fed ApoE(-/-) mice.	Rosuvastatin Calcium	97-109	mast cell protease 1	Mus musculus	233-238
27498121-9	2016	In addition, liriodendrin decreased the production of the proinflammatory mediators including (TNF-alpha, IL-1beta, MCP-1, and IL-6) in lung tissues.	liriodendrin	13-25	mast cell protease 1	Mus musculus	116-121
27734926-4	2016	On protein expression level, BMDMs showed an M2-like CD206highCD11clow profile, while cholesterol loading led to enhanced CD11c expression and reduced MCP-1 secretion.	Cholesterol	86-97	mast cell protease 1	Mus musculus	151-156
27734926-5	2016	In contrast, PEMs expressed low levels of CD206 and CD11c, and responded to cholesterol loading by increasing CD11c expression and MCP-1 secretion.	Cholesterol	76-87	mast cell protease 1	Mus musculus	131-136
27522255-7	2016	Aortic mRNA expression of macrophage inflammatory cytokines, including MCP-1, iNOS, IL-1beta, IL-6, CXCL9 and CXCL11, was also reduced in PA-treated mice.	patchouli alcohol	138-140	mast cell protease 1	Mus musculus	71-76
27698188-7	2016	Inhibition of either GRP78 or linoleic acid treatment increased MCP-1 serum levels, decreased CD47 expression, and increased macrophage infiltration, suggesting a novel role for GRP78 in regulating innate immunity.	Linoleic Acid	30-43	mast cell protease 1	Mus musculus	64-69
27487733-8	2016	GA also reduced hepatic inflammation via a decrease in the expression of the hepatic inflammatory genes MCP-1 and VCAM-1.	Glycyrrhizic Acid	0-2	mast cell protease 1	Mus musculus	104-109
27494684-5	2016	AA reduced the recruitment of inflammatory cells and MCP-1 expression in lung tissue of CS exposure mice.	Cesium	88-90	mast cell protease 1	Mus musculus	53-58
27161245-4	2016	METHODS AND RESULTS: Dietary oligonol supplementation (20 or 200 mg/kg bw) reduced glucose and insulin levels, improved oral glucose tolerance, and suppressed inflammatory markers, MCP-1 and IL-6, in High-Fat diet (HFD) induced obese mice.	oligonol	29-37	mast cell protease 1	Mus musculus	181-186
27172157-9	2016	Fibrinogen applied to myotubes evoked inflammatory responses (increased MCP-1 and TNF-alpha; 32.6 and 3.9-fold, respectively) and reduced MMP; these changes were ameliorated by glycyrrhizin treatment.	Glycyrrhizic Acid	177-189	mast cell protease 1	Mus musculus	72-77
27314544-9	2016	Mechanistic study showed that 4-hydroxynonenal significantly enhanced mRNA degradation of TNF-alpha, MCP-1, and MIP-1alpha, and decreased the protein levels of MCP-1 in LPS-stimulated Kupffer cells-SV40 through reducing the phosphorylation of mRNA binding proteins.	4-hydroxy-2-nonenal	30-46	mast cell protease 1	Mus musculus	101-106
27314544-9	2016	Mechanistic study showed that 4-hydroxynonenal significantly enhanced mRNA degradation of TNF-alpha, MCP-1, and MIP-1alpha, and decreased the protein levels of MCP-1 in LPS-stimulated Kupffer cells-SV40 through reducing the phosphorylation of mRNA binding proteins.	4-hydroxy-2-nonenal	30-46	mast cell protease 1	Mus musculus	160-165
27268284-3	2016	The study showed that pretreatment with 5Z-7-oxozeaenol not only remarkably decreased high glucose (HG) stimulated excessive release of MCP-1 and TNF-alpha, but also significantly down-regulated ERK1/2, p38MAPK phosphorylation, and NF-kappaB activation in macrophages.	5-7-oxo-zeaenol	40-55	mast cell protease 1	Mus musculus	136-141
27268284-3	2016	The study showed that pretreatment with 5Z-7-oxozeaenol not only remarkably decreased high glucose (HG) stimulated excessive release of MCP-1 and TNF-alpha, but also significantly down-regulated ERK1/2, p38MAPK phosphorylation, and NF-kappaB activation in macrophages.	Glucose	91-98	mast cell protease 1	Mus musculus	136-141
27613825-7	2016	Treatment with didemnin B improved several characteristics of hepatic lipotoxicity to a greater extent than the effects of caloric restriction alone, including hepatic steatosis, and some hepatic markers of ER stress and inflammation (GRP78, Xbp1s, and Mcp1).	didemnins	15-25	mast cell protease 1	Mus musculus	253-257
27351430-4	2016	Moreover, 1,8-cineol efficiently decreased the level of IL-4, IL-5, IL-10, and MCP-1 in nasal lavage fluids and the level of IL-1beta, IL-6, TNF-alpha, and IFN-gamma in lung tissues of mice infected with influenza virus.	Eucalyptol	10-20	mast cell protease 1	Mus musculus	79-84
27166928-7	2016	Investigated fatty acids changed mRNA levels of IL6 and MCP1 in young, mature and old cells.	Fatty Acids	13-24	mast cell protease 1	Mus musculus	56-60
27527870-9	2016	Ethanol caused pancreatic inflammation which was indicated by the induction of TNF-alpha, IL-1beta, IL-6, MCP-1 and CCR2, and the increase of CD68 positive macrophages in the pancreas.	Ethanol	0-7	mast cell protease 1	Mus musculus	106-111
27157410-11	2016	In vitro, COV08-0064 selectively blocked mRNA upregulation of TNF-alpha, IL-1beta, NLRP3 and MCP-1 in macrophages and IFN-beta mRNA in dendritic cells induced by the TLR9 agonist CpG-ODN.	6-N-methylnaltrexamine	10-20	mast cell protease 1	Mus musculus	93-98
27239754-9	2016	The effects of DP on bone were accompanied by a decline in interleukins, TNF and MCP-1, suggesting that DP is acting in part through the immune system to suppress inflammatory activity and reduce the size of the osteoclast precursor pool.	dp	15-17	mast cell protease 1	Mus musculus	81-86
27239754-9	2016	The effects of DP on bone were accompanied by a decline in interleukins, TNF and MCP-1, suggesting that DP is acting in part through the immune system to suppress inflammatory activity and reduce the size of the osteoclast precursor pool.	dp	104-106	mast cell protease 1	Mus musculus	81-86
27042761-7	2016	Additionally, it was noted that the levels of IL-1beta, IL-8 and MCP-1 were enhanced in the blood of mice exposed to both types of AlO NP and the percentages of neutrophils and monocytes among all white blood cells were increased only in mice injected with the long-type AlO NP (5 mg/kg).	alo np	131-137	mast cell protease 1	Mus musculus	65-70
27240856-5	2016	Mechanistically, ROFA exposure increased the levels of the circulating pro-inflammatory cytokines TNF-alpha, IL-6, and MCP-1, activated myeloid and endothelial cells, and enhanced leukocyte recruitment to the peritoneal cavity and the vascular endothelium.	rofa	17-21	mast cell protease 1	Mus musculus	119-124
27206490-16	2016	Treatment of CAFs with 1nM Everolimus showed a significant reduction in the expression of IL 8, IL 13, MCP1, MIF and Serpin E1.	cafs	13-17	mast cell protease 1	Mus musculus	103-107
27154637-4	2016	Inhibition of p38 but not other mitogen-activated protein kinases (MAPK) and PI3K further enhanced ESAT-6-induced MCP-1 production by BMDMs.	esat-6	99-105	mast cell protease 1	Mus musculus	114-119
27154637-6	2016	ESAT-6 also induced TNF-alpha from BMDMs and MCP-1 from mouse lung epithelial cells, and these were suppressed by p38 MAPK inhibition, implying cytokine- and cell-specific effect of p38 MAPK inhibition on ESAT-6-induced MCP-1 by macrophages.	esat-6	0-6	mast cell protease 1	Mus musculus	45-50
27154637-6	2016	ESAT-6 also induced TNF-alpha from BMDMs and MCP-1 from mouse lung epithelial cells, and these were suppressed by p38 MAPK inhibition, implying cytokine- and cell-specific effect of p38 MAPK inhibition on ESAT-6-induced MCP-1 by macrophages.	esat-6	0-6	mast cell protease 1	Mus musculus	220-225
27357136-7	2016	Pristane-treated WT mice showed elevated anti-dsDNA, anti-snRNP, CXCL1, and MCP-1 levels compared to untreated mice; however levels of anti-snRNP, MCP-1, and CXCL1 were reduced in pristane-treated Psgl-1(-/-) mice compared to pristane-treated WT mice.	pristane	0-8	mast cell protease 1	Mus musculus	76-81
27357136-7	2016	Pristane-treated WT mice showed elevated anti-dsDNA, anti-snRNP, CXCL1, and MCP-1 levels compared to untreated mice; however levels of anti-snRNP, MCP-1, and CXCL1 were reduced in pristane-treated Psgl-1(-/-) mice compared to pristane-treated WT mice.	pristane	0-8	mast cell protease 1	Mus musculus	147-152
26976763-13	2016	The release of cytokines and chemokines (IL-4, TNF-alpha, MCP-1) from activated RBL-2H3 cells were also attenuated by pretreatment with HLJDE.	hljde	136-141	mast cell protease 1	Mus musculus	58-63
27206490-16	2016	Treatment of CAFs with 1nM Everolimus showed a significant reduction in the expression of IL 8, IL 13, MCP1, MIF and Serpin E1.	CHEMBL2426582	23-26	mast cell protease 1	Mus musculus	103-107
27206490-16	2016	Treatment of CAFs with 1nM Everolimus showed a significant reduction in the expression of IL 8, IL 13, MCP1, MIF and Serpin E1.	Everolimus	27-37	mast cell protease 1	Mus musculus	103-107
26976763-10	2016	RESULTS: HLJDE could significantly suppress the secretion of NO, IL-1beta, IL-4, MCP-1 and GM-CSF in RAW264.7 cells in a dose-dependent manner.	hljde	9-14	mast cell protease 1	Mus musculus	81-86
26867493-7	2016	The reduction in alcohol-induced fat accumulation in miR-155 KO mice was associated with increased peroxisome proliferator-activated receptor response element (PPRE) and peroxisome proliferator-activated receptors (PPAR)alpha (miR-155 target) binding and decreased MCP1 production.	Alcohols	17-24	mast cell protease 1	Mus musculus	265-269
27144271-9	2016	In addition, the mRNA levels of pro-inflammatory genes such as TNF-alpha, MCP-1, IL-1beta and IL-6 in the liver were dose-dependently reduced by paeonol pre-treatment.	paeonol	145-152	mast cell protease 1	Mus musculus	74-79
27016588-4	2016	Although MV-O2 induced larger and fewer alveoli in both, TNF-alpha(-/-) and TNF-alpha(+/+) mice, it caused enhanced lung apoptosis (TUNEL, caspase-3/-6/-8), infiltration of macrophages and neutrophils, and proinflammatory mediator expression (IL-1beta, CXCL-1, MCP-1) in TNF-alpha(-/-) mice.	mv-o2	9-14	mast cell protease 1	Mus musculus	261-266
27171144-4	2016	In addition, PFOS increased transcription of inflammatory cytokines (i.e., TNFalpha, ICAM1, and MCP1) by NFkappaB activation.	perfluorooctane sulfonic acid	13-17	mast cell protease 1	Mus musculus	96-100
26567290-7	2016	The Th17-dependent secondary immune response against deposited NTS in the glomeruli was totally impaired in FR-ob/obmice because of deteriorated IL-17 and proinflammatory cytokine production including IL-23 and MCP-1 in the kidney.	nts	63-66	mast cell protease 1	Mus musculus	211-216
26062773-10	2016	After treatment with clopidogrel P-/E-selectin levels and cytokine levels of MCP-1 and PDGFbeta were significantly reduced as compared to controls.	Clopidogrel	21-32	mast cell protease 1	Mus musculus	77-82
26944017-2	2016	When administered to the C57BL/6J mice after a 3 days period of cigarettes exposure,TAK-242 significantly decreased the accumulation of macrophages, neutrophils, lymphocytes and DCs, and upregulation of IL-6, IL-8 and TNF-alpha in BAL fluid and lungs in a dose-dependent manner, except MCP-1, IL-1beta and IFN-gamma, which demonstrated that TAK-242 inhibits release of various inflammatory mediators induced by cigarette smoke.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	84-91	mast cell protease 1	Mus musculus	286-291
27158235-7	2016	RESULTS: The AQ extract caused significant increases in the expression of common inflammatory genes (e.g., Mcp1, Ccl5, Tnf-alpha, Nos2) in both cell types.	aq	13-15	mast cell protease 1	Mus musculus	107-111
27186263-7	2016	Renal expressions of TNF-alpha, MCP-1, Nox2 and p47phox and renal TBARS levels, markers of inflammation and oxidative stress, were increased during disease progression in diabetic mice, which were reduced by eplerenone or enalapril given alone and further reduced by the two drugs given in combination.	Eplerenone	208-218	mast cell protease 1	Mus musculus	32-37
27158384-7	2016	IL-6 and MCP-1 in lung tissues and BALF in methazolamide-treated mice were statistically decreased.	Methazolamide	43-56	mast cell protease 1	Mus musculus	9-14
26781273-6	2016	MCP and canrenoate also reduced cardiac hypertrophy and fibrosis and the expression of genes involved in fibrogenesis (Coll-1 and Coll-3) and macrophage infiltration (CD-68 and MCP-1).	Canrenoic Acid	8-18	mast cell protease 1	Mus musculus	177-182
26897632-0	2016	L-Cysteine supplementation increases adiponectin synthesis and secretion, and GLUT4 and glucose utilization by upregulating disulfide bond A-like protein expression mediated by MCP-1 inhibition in 3T3-L1 adipocytes exposed to high glucose.	Cysteine	0-10	mast cell protease 1	Mus musculus	177-182
26802469-4	2016	Linagliptin and higher concentrations of sitagliptin, vildagliptin, and alogliptin all inhibited FFA-bound albumin-induced increases in mRNA expression of MCP-1 in cultured mouse proximal tubular cells.	Linagliptin	0-11	mast cell protease 1	Mus musculus	155-160
26783339-8	2016	In addition, UDP-induced MCP-1 secretion was significantly reduced by MRS2578, FFA, and P2Y6 mutation.	Uridine Diphosphate	13-16	mast cell protease 1	Mus musculus	25-30
26802469-4	2016	Linagliptin and higher concentrations of sitagliptin, vildagliptin, and alogliptin all inhibited FFA-bound albumin-induced increases in mRNA expression of MCP-1 in cultured mouse proximal tubular cells.	Sitagliptin Phosphate	41-52	mast cell protease 1	Mus musculus	155-160
26802469-4	2016	Linagliptin and higher concentrations of sitagliptin, vildagliptin, and alogliptin all inhibited FFA-bound albumin-induced increases in mRNA expression of MCP-1 in cultured mouse proximal tubular cells.	Vildagliptin	54-66	mast cell protease 1	Mus musculus	155-160
26802469-4	2016	Linagliptin and higher concentrations of sitagliptin, vildagliptin, and alogliptin all inhibited FFA-bound albumin-induced increases in mRNA expression of MCP-1 in cultured mouse proximal tubular cells.	alogliptin	72-82	mast cell protease 1	Mus musculus	155-160
25388157-5	2016	The real-time PCR studies showed that (1) inhalational silica induced inflammatory responses in the heart and kidney by elevated mRNA levels of TNF-alpha, IL-6 and MCP-1; (2) early fibrotic responses in the heart were observed as elevated mRNA levels of collagen I and fibronectin.	Silicon Dioxide	55-61	mast cell protease 1	Mus musculus	164-169
26687933-12	2016	Additionally, leucine supplementation did not affect the serum levels of IL-6, IFN-gamma, TNF-alpha, IL-10 and IL-12, but markedly decreased the serum level of MCP-1.	Leucine	14-21	mast cell protease 1	Mus musculus	160-165
26564716-9	2016	In addition, RAW 264.7 macrophages loaded with exogenous iron showed significantly higher levels of inflammatory markers (Inos, Tnfalpha, Mcp1, Tlr4).	Iron	57-61	mast cell protease 1	Mus musculus	138-142
26794215-6	2016	The results showed that aspirin treatment inhibited differentiation and lipid accumulation by 3T3-L1 preadipocytes, and decreased the secretion of the inflammatory adipokine MCP-1 after stimulation with tumor necrosis factor (TNF)-alpha or conditioned medium from RAW264.7 cells.	Aspirin	24-31	mast cell protease 1	Mus musculus	174-179
26794215-7	2016	In 4T1 cells, treatment with aspirin decreased cell viability and migration, possibly by suppressing MCP-1 and VEGF secretion.	Aspirin	29-36	mast cell protease 1	Mus musculus	101-106
26794215-10	2016	Aspirin treatment significantly inhibited the proliferation of 4T1 cells, and decreased the production of MCP-1 and PAI-1 in both the Ad-CM model and co-culture system.	Aspirin	0-7	mast cell protease 1	Mus musculus	106-111
26794215-11	2016	Aspirin inhibited inflammatory MCP-1 adipokine production by 3T3-L1 adipocytes and the cell growth and migration of 4T1 cells.	Aspirin	0-7	mast cell protease 1	Mus musculus	31-36
26919956-9	2016	CONCLUSIONS: N-Acetyl-l-cysteine can lower the incidence rate of infection-associated preterm labor by prohibiting the activation of the protein AP-1/MCP-1 and decreasing the expression of NF-kappaBp65 and TNF-alpha in the pregnant tissues of premature mice to reduce the inflammatory reactions.	Acetylcysteine	13-32	mast cell protease 1	Mus musculus	150-155
26506421-5	2016	Specifically, cardamonin effectively abolishes chemotherapeutic drug-induced up-regulation of IL-6, IL-8 and MCP-1 and activation of NF-kappaB/IKBalpha and Stat3.	cardamonin	14-24	mast cell protease 1	Mus musculus	109-114
26713365-5	2016	In contrast, addition of heparin to the medium suppressed MCP-1 release in a dose-dependent manner.	Heparin	25-32	mast cell protease 1	Mus musculus	58-63
26515692-0	2016	Phosphodiesterase-5 inhibition promotes remyelination by MCP-1/CCR-2 and MMP-9 regulation in a cuprizone-induced demyelination model.	Cuprizone	95-104	mast cell protease 1	Mus musculus	57-62
26492523-12	2016	In addition, 5z-7-oxozeaenol, LY294002, U0126 and aspirin prevented the IL-1beta-induced MCP-1 secretion of pulp cells.	5-7-oxo-zeaenol	13-28	mast cell protease 1	Mus musculus	89-94
26492523-12	2016	In addition, 5z-7-oxozeaenol, LY294002, U0126 and aspirin prevented the IL-1beta-induced MCP-1 secretion of pulp cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	mast cell protease 1	Mus musculus	89-94
26492523-12	2016	In addition, 5z-7-oxozeaenol, LY294002, U0126 and aspirin prevented the IL-1beta-induced MCP-1 secretion of pulp cells.	U 0126	40-45	mast cell protease 1	Mus musculus	89-94
26492523-12	2016	In addition, 5z-7-oxozeaenol, LY294002, U0126 and aspirin prevented the IL-1beta-induced MCP-1 secretion of pulp cells.	Aspirin	50-57	mast cell protease 1	Mus musculus	89-94
27643515-9	2016	DMDD inhibited inflammatory cytokines IL-6, TNF-alpha and MCP-1 generations in palmitic acid (PA)-induced Min6 cells.	2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione	0-4	mast cell protease 1	Mus musculus	58-63
27643515-9	2016	DMDD inhibited inflammatory cytokines IL-6, TNF-alpha and MCP-1 generations in palmitic acid (PA)-induced Min6 cells.	Palmitic Acid	79-92	mast cell protease 1	Mus musculus	58-63
27643515-9	2016	DMDD inhibited inflammatory cytokines IL-6, TNF-alpha and MCP-1 generations in palmitic acid (PA)-induced Min6 cells.	Palmitic Acid	94-96	mast cell protease 1	Mus musculus	58-63
27744426-9	2016	The mRNA and protein expressions of CD68, MCP1, and CXCR3 in the obstructed kidney were significantly decreased by sorafenib.	Sorafenib	115-124	mast cell protease 1	Mus musculus	42-46
26515692-12	2016	CPZ induced an increase in the expression of IL-1beta and a decrease in MCP-1, CCR-2, MBP and GST-pi, as well as promoting damage in the structure and ultra-structure of the myelin sheath.	Cuprizone	0-3	mast cell protease 1	Mus musculus	72-77
26515692-16	2016	Therefore, the present study shows that sildenafil modulates inflammation, with the involvement of MMP-9, MCP-1, and CCR-2, and also contributes to myelin repair.	Sildenafil Citrate	40-50	mast cell protease 1	Mus musculus	106-111
26489728-10	2015	Prasugrel treatment resulted in reduced MCP-1, ICAM-1 and TGF-beta mRNA levels on Day 2 (24h after the injury) and Day 8 (1 week after the injury) in the target arteries.	Prasugrel Hydrochloride	0-9	mast cell protease 1	Mus musculus	40-45
26464379-4	2016	Additionally, immunization with rOhr induced high production of IFN-gamma as well as proinflammatory cytokines such as TNF, MCP-1, IL-12p70, and IL-6, but a lesser amount of IL-10, suggesting that rOhr predominantly elicited a cell-mediated immune response.	rohr	32-36	mast cell protease 1	Mus musculus	124-129
26432179-9	2015	Our results showed that treatment of linalool significantly attenuated CS-induced lung inflammation, coupled with inhibited the infiltration of inflammatory cells and TNF-alpha, IL-6, IL-1beta, IL-8 and MCP-1 production.	linalool	37-45	mast cell protease 1	Mus musculus	203-208
26482537-9	2015	Moreover, saturated fat-induced NFkappaB signaling and elevation of TNFalpha and MCP1 mRNA in HepG2 cells was blocked by targeted knockdown of S1P receptor 1, supporting a role for this lipid signaling pathway in inflammation in nonalcoholic fatty liver disease.	saturated fat	10-23	mast cell protease 1	Mus musculus	81-85
26807019-8	2016	Further results showed that CA treatment markedly inhibited APAP-induced pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6 and MCP-1 mRNA expression and the levels of phosphorylated IkappaBalpha and p65 protein in the liver.	Acetaminophen	60-64	mast cell protease 1	Mus musculus	130-135
26489728-11	2015	In conclusion, we found that a single oral loading dose of prasugrel markedly prevented neointimal hyperplasia by inhibiting platelet activation and thrombus formation and was associated with inhibition of the expression of inflammatory and fibrosis markers, including MCP-1, ICAM-1 and TGF-beta, in the injured arteries.	Prasugrel Hydrochloride	59-68	mast cell protease 1	Mus musculus	269-274
25694398-7	2015	The accumulation of TAMs in apn(-/-) mice was also reduced which correlated to downregulated serum levels of MCP-1.	tams	20-24	mast cell protease 1	Mus musculus	109-114
26409626-10	2015	Co-treatment with NPY1R antagonist decreased the expressions of TNF-alpha, CRP and MCP-1 in NPY and METH treated cells.	Methamphetamine	100-104	mast cell protease 1	Mus musculus	83-88
25324219-9	2015	Treatment of chemical chaperone 4-phenyle-butyric acid alleviated ER stress in adipose tissue stromal cells and adipose tissue macrophages and attenuated the production of IL-6 and MCP-1 by adipose tissue stromal cells, and TNF-alpha by adipose tissue macrophages from both young and old mice.	4-phenyle-butyric acid	32-54	mast cell protease 1	Mus musculus	181-186
26277481-8	2015	Our data showed that quercetin inhibited the MAPK signaling factors ERK1/2, JNK and p38MAPK and MCP-1 and TNF-alpha in adipocytes and macrophages.	Quercetin	21-30	mast cell protease 1	Mus musculus	96-101
26509261-11	2015	In in vitro experiments, SHED significantly decreased MCP-1 secretion in tubular epithelial cells (TEC) stimulated with H2O2.	Hydrogen Peroxide	120-124	mast cell protease 1	Mus musculus	54-59
25543187-9	2015	Among those 6 biomarkers, NGAL, M-CSF, and MCP-1 showed significantly higher values in the urine of DBA/2FG-pcy mice than that of wild type.	1,2,5,6-dibenzanthracene	100-103	mast cell protease 1	Mus musculus	43-48
26047123-7	2015	BMEV treatment also reduced the serum levels of MCP-1 and IL-6 and their production by splenic cells.	bmev	0-4	mast cell protease 1	Mus musculus	48-53
26179875-7	2015	Whey IgE and IgG1 levels remained unaltered, whereas mMCP-1 levels increased in mice fed the 10 % soyabean oil diet.	Oils	107-110	mast cell protease 1	Mus musculus	53-59
26593910-6	2015	We demonstrated that brazilein decreased the expression of IRAK4 protein led to the suppression of MAPK signaling and IKKbeta, and subsequent inactivation of NF-kappaB and COX2 thus promoting the expression of the downstream target pro-inflammatory cytokines such as IL-1beta, MCP-1, MIP-2, and IL-6 in LPS-induced Raw264.7 macrophage cells.	brazilein	21-30	mast cell protease 1	Mus musculus	277-282
26297476-11	2015	In vitro results revealed that piceatannol inhibited migration of 4T1 cells and monocytes, as well as secretion of MCP-1 and M-CSF by 4T1 cells.	3,3',4,5'-tetrahydroxystilbene	31-42	mast cell protease 1	Mus musculus	115-120
26252371-10	2015	In addition, gemcitabine upregulated the angiogenic molecules IL-6, IL-8, ENA-78 and MCP-1.	gemcitabine	13-24	mast cell protease 1	Mus musculus	85-90
25541056-4	2015	Butein also decreased TNF-alpha-induced pro-inflammatory mediators, such as IL-6, IP-10 and MCP-1, in HaCaT cells.	butein	0-6	mast cell protease 1	Mus musculus	92-97
26241646-8	2015	A higher neutrophil influx and enhanced IL-6, MCP-1 and KC production was observed in Nur77-deficient colons after DSS-treatment.	dss	115-118	mast cell protease 1	Mus musculus	46-51
26241646-9	2015	TNBS-induced influx of T-cells and inflammatory monocytes into the colon was higher in Nur77-/- mice, along with increased expression of MCP-1, TNFalpha and IL-6, and decreased Foxp3 RNA expression, compared to wild-type mice.	Trinitrobenzenesulfonic Acid	0-4	mast cell protease 1	Mus musculus	137-142
25985797-5	2015	Our results show that preincubation of 3T3-L1 cells with alpha7nAChR agonist GTS-21 significantly reduces ASP-mediated chemokine MCP-1 secretion, which is regulated though nuclear factor kappaB (NFkappaB) and signal transducer and activator of transcription 3 (STAT3).	3-(2,4-dimethoxybenzylidene)anabaseine	77-83	mast cell protease 1	Mus musculus	129-134
26114959-5	2015	Phage display analysis showed that it is a chymase with a specificity similar to the corresponding enzyme in mice, mMCP-1, with a preference for Phe or Tyr in the P1 position, and a general preference for aliphatic amino acids both upstream and downstream of the cleavage site.	Phenylalanine	145-148	mast cell protease 1	Mus musculus	115-121
25891417-8	2015	Casticin and chrysosplenol D suppressed LPS-induced release of IL-1 beta, IL-6 and MCP-1, inhibited cell migration, and reduced LPS-induced IkappaB and c-JUN phosphorylation in Raw264.7 cells.	casticin	0-8	mast cell protease 1	Mus musculus	83-88
25891417-8	2015	Casticin and chrysosplenol D suppressed LPS-induced release of IL-1 beta, IL-6 and MCP-1, inhibited cell migration, and reduced LPS-induced IkappaB and c-JUN phosphorylation in Raw264.7 cells.	Chrysosplenol C	13-26	mast cell protease 1	Mus musculus	83-88
26114959-5	2015	Phage display analysis showed that it is a chymase with a specificity similar to the corresponding enzyme in mice, mMCP-1, with a preference for Phe or Tyr in the P1 position, and a general preference for aliphatic amino acids both upstream and downstream of the cleavage site.	Tyrosine	152-155	mast cell protease 1	Mus musculus	115-121
26021377-13	2015	In the regenerated tissue, BrdU-positive migrated cells expressed CXCR4 and CCR2, receptors for CXCL14 and MCP1, respectively.	Bromodeoxyuridine	27-31	mast cell protease 1	Mus musculus	107-111
26042828-9	2015	In mice, mild water restriction that elevates serum sodium by 5 mmol/l, increased VCAM1, E-selectin and MCP-1 expression in mouse tissues, accelerated atherosclerotic plaque formation in aortic root and caused thickening or walls of coronary arteries.	Water	14-19	mast cell protease 1	Mus musculus	104-109
25629551-2	2015	In vitro, lipopolysaccharide (LPS) or adriamycin (ADR) elicited podocyte injury and cytoskeletal disruption, associated with NFkappaB activation and induced expression of NFkappaB target molecules, including pro-survival Bcl-xL and podocytopathic mediators like MCP-1, cathepsin L, and B7-1.	Doxorubicin	38-48	mast cell protease 1	Mus musculus	262-267
25895126-5	2015	Metformin treatment in RD and HED mice resulted in a significant reduction in tumor burden in the peritoneum, liver, kidney, spleen and bowel accompanied by decreased levels of growth factors (IGF-1, insulin and leptin), inflammatory cytokines (MCP-1, IL-6) and VEGF in plasma and ascitic fluid, akin to the CR diet mice.	Metformin	0-9	mast cell protease 1	Mus musculus	245-250
25840915-8	2015	Poly(I:C), but not HSV60, also dramatically induced the expression of major proinflammatory cytokines, including TNF-alpha and MCP-1, in EECs.	Poly I-C	0-8	mast cell protease 1	Mus musculus	127-132
25811291-8	2015	Pre-treatment of the cells with the bioaccessible fractions from PGBR and BR suppressed the secretion of IL-8 and MCP-1 and the ROS content in activated cells.	pgbr	65-69	mast cell protease 1	Mus musculus	114-119
25572138-10	2015	More importantly, haloperidol markedly lowered MCP-1 expression (-70%) and secretion (-28%) by peritoneal macrophages.	Haloperidol	18-29	mast cell protease 1	Mus musculus	47-52
25499102-10	2015	RESULTS: Oral allergen challenge (OAC) of transdermal sensitized mice results in hypothermia, hypotension, tachycardia and rapid elevation of circulating mMCP-1.	SDZ 33-243	34-37	mast cell protease 1	Mus musculus	154-160
25740962-4	2015	Chronic alcohol feeding in C57Bl/6 mice led to increased expression of M1 (TNF-alpha, MCP1, and IL-1beta) and M2 (Arg1, Mrc1, and IL-10) genes and the frequency of CD206+CD163+ M2 macrophages in the liver.	Alcohols	8-15	mast cell protease 1	Mus musculus	86-90
25637544-7	2015	Mechanistically, we showed that 17-DMAG prevented the formation and progression of AAA through its inhibitory effects on diverse biological pathways including 1) by blocking ANG II-induced phosphorylation of ERK1/2 and JNK that are critically involved in the regulation of MMPs in vascular smooth muscle cells, 2) by inhibiting IkappaB kinase expression and expression of MCP-1, and 3) by attenuating ANG II-stimulated angiogenic processes critical to AAA formation.	17-(dimethylaminoethylamino)-17-demethoxygeldanamycin	32-39	mast cell protease 1	Mus musculus	372-384
25812588-10	2015	However, NG pretreatment reversed the inflammatory development through downregulation of NF-kappaB, and regulated the expression of CRP, MCP-1, and iNOS2.	naringin	9-11	mast cell protease 1	Mus musculus	137-142
25145931-7	2015	Furthermore, the increase in proinflammatory cytokine (CXCL1, MCP-1, TNF-alpha, and IL-6) expression and infiltration of neutrophils and macrophages induced by cisplatin treatment was attenuated by FTY720 in control mice but not in PT-S1P1-null mice.	Cisplatin	160-169	mast cell protease 1	Mus musculus	62-67
26517816-10	2015	In ex-vivo study, LPS induced prominent production of IL-1beta and MCP-1 in cultured RAW264.7 cells, which was significantly suppressed by rapamycin.	Sirolimus	139-148	mast cell protease 1	Mus musculus	67-72
25747123-6	2015	This led to decreased MCP1/CCR2 dependent macrophage infiltration into adipose tissue and reduced inflammation, resulting in improved glucose tolerance and insulin sensitivity.	Glucose	134-141	mast cell protease 1	Mus musculus	22-26
25878893-4	2015	The NPs with Cibacron Blue F3G-A and Reactive Blue-4 baits demonstrated a low-micromolar affinity binding to IL-8, MIP-2, and MCP-1 with a half-life of several hours at 37 C. The capacity of NPs loaded with IL-8 and MIP-1alpha to increase neutrophil recruitment to lymph nodes (LNs) was tested in mice after footpad injection.	Cibacron Blue	13-26	mast cell protease 1	Mus musculus	126-131
25585347-3	2015	The pretreatment of cells with IFN-gamma dramatically increased the expression of iopromide-induced IL-4 and MCP-1.	iopromide	82-91	mast cell protease 1	Mus musculus	109-114
25877037-8	2015	DHA decreased the expression of palmitate-caused pro-inflammatory cytokines (MCP-1, IL-6 and iNOS) and oxidative stress and increased the gene expression of insulin signaling pathway (Glut4 and p-IRbeta).	Docosahexaenoic Acids	0-3	mast cell protease 1	Mus musculus	77-82
25877037-8	2015	DHA decreased the expression of palmitate-caused pro-inflammatory cytokines (MCP-1, IL-6 and iNOS) and oxidative stress and increased the gene expression of insulin signaling pathway (Glut4 and p-IRbeta).	Palmitates	32-41	mast cell protease 1	Mus musculus	77-82
25454805-5	2015	Exogenous MCP-1 by interacting CCR-2 leads to the release of nitric oxide and ROS that are important for bacterial clearance.	Nitric Oxide	61-73	mast cell protease 1	Mus musculus	10-15
25454805-5	2015	Exogenous MCP-1 by interacting CCR-2 leads to the release of nitric oxide and ROS that are important for bacterial clearance.	Reactive Oxygen Species	78-81	mast cell protease 1	Mus musculus	10-15
25454805-6	2015	In this experimental setup, the possible molecular pathway connecting an increase in proinflammatory cytokine levels with increased ROS/NO production, and therefore increased killing activity, possibly by involving either MyD88 dependent or RhoA GTPases dependent NF-kappaB activation or endogenous synthesis of MCP-1, independent of TLR-2-MyD88 pathway.	Reactive Oxygen Species	132-135	mast cell protease 1	Mus musculus	312-317
25454805-7	2015	Thus, induction of CCR-2/MCP-1 signalling by macrophages depending on the availability of MCP-1 during S. aureus infection may be important for regulation of septic shock by induction of reactive oxygen species and various cytokines.	Reactive Oxygen Species	187-210	mast cell protease 1	Mus musculus	25-30
25454805-7	2015	Thus, induction of CCR-2/MCP-1 signalling by macrophages depending on the availability of MCP-1 during S. aureus infection may be important for regulation of septic shock by induction of reactive oxygen species and various cytokines.	Reactive Oxygen Species	187-210	mast cell protease 1	Mus musculus	90-95
25446779-4	2015	We used WT, TLR4-KO and TLR2-KO mice treated with alcohol for 5 months to show that chronic ethanol consumption increases the levels of cytokines (IL-1beta, IL-17, TNF-alpha) and chemokines (MCP-1, MIP-1alpha, CX3CL1) in the striatum and serum (MCP-1, MIP-1alpha, CX3CL1) of WT mice.	Ethanol	92-99	mast cell protease 1	Mus musculus	191-196
25446779-4	2015	We used WT, TLR4-KO and TLR2-KO mice treated with alcohol for 5 months to show that chronic ethanol consumption increases the levels of cytokines (IL-1beta, IL-17, TNF-alpha) and chemokines (MCP-1, MIP-1alpha, CX3CL1) in the striatum and serum (MCP-1, MIP-1alpha, CX3CL1) of WT mice.	Ethanol	92-99	mast cell protease 1	Mus musculus	245-250
25496441-8	2015	Furthermore, PCAF deficiency reduced palmitate-induced recruitment of H3K18ac on the promoters of ICAM-1 and MCP-1, as well as inhibited palmitate-induced upregulation of these inflammatory molecules.	Palmitates	37-46	mast cell protease 1	Mus musculus	109-114
25703166-5	2015	The subcutaneous injection of SR-ONO (3mg/kg) every 3 wks did not affect the obesity or hyperglycemia in the db/db obese mice used as a model of type 2 diabetes, but it significantly ameliorated their albuminuria, glomerular hypertrophy, glomerular accumulation of type IV collagen, and monocyte/macrophage infiltration, and also the increase of TGF-beta1, alpha-smooth muscle actin (alpha-SMA) and MCP-1 compared to vehicle treatment.	sr-ono	30-36	mast cell protease 1	Mus musculus	399-404
25703166-6	2015	In cultured mouse mesangial cells, ONO-1301 concentration-dependently suppressed the increases in TGF-beta, type IV collagen, alpha-SMA, MCP-1 and fibronectin induced by high ambient glucose, at least partly through prostacyclin (PGI2) receptor-mediated signaling.	ONO 1301	35-43	mast cell protease 1	Mus musculus	137-142
24975165-7	2015	LY294002 and IC87114 prevented Akt phosphorylation as expected and down-regulated the expression of inflammatory factors IL-6, MCP-1,TNFalpha and iNOS.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	mast cell protease 1	Mus musculus	127-132
24975165-7	2015	LY294002 and IC87114 prevented Akt phosphorylation as expected and down-regulated the expression of inflammatory factors IL-6, MCP-1,TNFalpha and iNOS.	IC 87114	13-20	mast cell protease 1	Mus musculus	127-132
25728636-3	2015	In the cell model, Dp3-Sam and Delphinidin (Dp) reduced the levels of inflammatory mediators including iNOS, NO, IL-6, MCP-1, and TNF-alpha induced by LPS.	delphinidin	31-42	mast cell protease 1	Mus musculus	119-124
25728636-3	2015	In the cell model, Dp3-Sam and Delphinidin (Dp) reduced the levels of inflammatory mediators including iNOS, NO, IL-6, MCP-1, and TNF-alpha induced by LPS.	delphinidin	19-21	mast cell protease 1	Mus musculus	119-124
25728636-5	2015	In animal model, Dp3-Sam and Dp reduced the production of IL-6, MCP-1 and TNF-alpha and attenuated mouse paw edema induced by LPS.	delphinidin	17-19	mast cell protease 1	Mus musculus	64-69
25861160-7	2015	Moreover, the circulating TNF-alpha, renal TNF-alpha, IL-1beta, MCP-1, ICAM-1, and VACAM-1 mRNA levels were higher in the cisplatin-treated mice, compared with the controls, but they were attenuated in the OA-NO2 pretreatment group.	Cisplatin	122-131	mast cell protease 1	Mus musculus	64-69
25653480-6	2015	The DNA-binding activity of NF-kappaB was suppressed and expression of several key inflammatory mediators including TNF-alpha, IL-1alpha, IL-1beta, IL-12, IL-17, and MCP-1 was lowered in the high-dose bortezomib-treated group.	Bortezomib	201-211	mast cell protease 1	Mus musculus	166-171
26508815-3	2015	Seven days after UUO, there were significant reductions in the expression of both collagen 1 and collagen 3 in kidneys treated with Ac-SDKP or Captopril, and there was a trend towards reductions in collagen IV, alpha-SMA, and MCP-1 versus control.	goralatide	132-139	mast cell protease 1	Mus musculus	226-231
26783382-8	2015	High-salt significantly promotes IL-6 and MCP-1 production by ARPE-19 cells and is associated with activation of the p38 MAPK, Akt, and NF-kappaB pathway and NFAT-SGK1 pathways.	Salts	5-9	mast cell protease 1	Mus musculus	42-47
25307205-6	2014	Supplementation with alpha- and mixed-tocopherol reduced systemic concentrations of IL-6 (P &lt; 0.001 and P &lt; 0.001, respectively) and IL-10 (P &lt; 0.05 and P &lt; 0.001, respectively), while alpha-tocopherol also reduced MCP-1 (P &lt; 0.05) and tumor necrosis factor (TNF)-alpha (P &lt; 0.05).	alpha- and mixed-tocopherol	21-48	mast cell protease 1	Mus musculus	227-232
25031296-6	2014	Aliskiren and/or valsartan significantly prevented increased expression of profibrotic growth factors (TGFbeta, CTGF and PAI-1), proinflammatory cytokines (MCP-1, TNFalpha and IL-1beta), endoplasmic reticulum (ER) stress markers (CHOP and XBP-1) and lipid accumulation in the kidney of diabetic animals.	aliskiren	0-9	mast cell protease 1	Mus musculus	156-161
25031296-6	2014	Aliskiren and/or valsartan significantly prevented increased expression of profibrotic growth factors (TGFbeta, CTGF and PAI-1), proinflammatory cytokines (MCP-1, TNFalpha and IL-1beta), endoplasmic reticulum (ER) stress markers (CHOP and XBP-1) and lipid accumulation in the kidney of diabetic animals.	Valsartan	17-26	mast cell protease 1	Mus musculus	156-161
25116192-5	2014	RESULTS: Compared to C, STZ-WT mice had significantly increased macrophage and TLR4 immunostaining in kidney, significant increases in MyD88, Interferon Regulatory Factor-3, NFKappaB activity, TNF-Alpha, IL-6, and MCP-1; all these were significantly decreased in the STZ-TLR4KO compared to STZ-WT mice.	Streptozocin	24-27	mast cell protease 1	Mus musculus	214-219
25369140-10	2014	These data demonstrate that curcumin can suppress inflammation by inhibiting macrophage migration via NFkappaB and MCP-1 inhibition and establish that NEC is an effective therapeutic formulation to increase the bioavailability of curcumin in order to facilitate this response.	Curcumin	28-36	mast cell protease 1	Mus musculus	115-120
25450688-8	2014	Overexpression of FABP3 resulted in a greater response to palmitate, a satulated FA, to induce MCP-1 in the rat mesangial cells.	Palmitates	58-67	mast cell protease 1	Mus musculus	95-100
25050617-5	2014	In vivo, pharmacological inhibition of TAK1 with 5Z-7-oxozeaenol blocked the injury-induced phosphorylation of both TAK1 (Thr187) and NF-kB/p65 (Ser536), associated with marked inhibition of superoxide production, 3-nitrotyrosine, and MCP-1 in the injured arteries.	5-7-oxo-zeaenol	49-64	mast cell protease 1	Mus musculus	235-240
25442271-7	2014	Artesunate suppressed cigarette smoke-induced increases in BAL fluid total and differential cell counts; levels of IL-1beta, MCP-1, IP-10 and KC; and levels of oxidative biomarkers 8-isoprostane, 8-OHdG and 3-nitrotyrosine in a dose-dependent manner.	Artesunate	0-10	mast cell protease 1	Mus musculus	125-130
25277804-10	2014	HG induced changes in MCP-1 and adiponectin secretion were partly attenuated by forced expression of CSE or sodium hydrosulfide (NaHS), a source of exogenous H2S.	sodium bisulfide	108-127	mast cell protease 1	Mus musculus	22-27
25277804-10	2014	HG induced changes in MCP-1 and adiponectin secretion were partly attenuated by forced expression of CSE or sodium hydrosulfide (NaHS), a source of exogenous H2S.	sodium bisulfide	129-133	mast cell protease 1	Mus musculus	22-27
24669857-5	2014	Nicotine"s effect on the expression of cell surface Toll-like receptors (TLRs), MCP-1, COX-2, and TNF-alpha were examined by real-time PCR.	Nicotine	0-8	mast cell protease 1	Mus musculus	80-85
25017431-9	2014	In addition, probucol alone and probucol plus cilostazol decreased MCP-1 expression and CD11b and GFAP immuno-reactivity in the ischemic cortex.	Probucol	13-21	mast cell protease 1	Mus musculus	67-72
25017431-9	2014	In addition, probucol alone and probucol plus cilostazol decreased MCP-1 expression and CD11b and GFAP immuno-reactivity in the ischemic cortex.	Probucol	32-40	mast cell protease 1	Mus musculus	67-72
25017431-9	2014	In addition, probucol alone and probucol plus cilostazol decreased MCP-1 expression and CD11b and GFAP immuno-reactivity in the ischemic cortex.	Cilostazol	46-56	mast cell protease 1	Mus musculus	67-72
25017431-10	2014	These findings suggested that the inhibitory effects of probucol plus cilostazol in MCP-1 expression in the ischemic brain with hypercholesterolemia allowed the identification of one of the mechanisms responsible for anti-inflammatory action.	Probucol	56-64	mast cell protease 1	Mus musculus	84-89
25017431-10	2014	These findings suggested that the inhibitory effects of probucol plus cilostazol in MCP-1 expression in the ischemic brain with hypercholesterolemia allowed the identification of one of the mechanisms responsible for anti-inflammatory action.	Cilostazol	70-80	mast cell protease 1	Mus musculus	84-89
25314304-4	2014	Our observations showed that pretreatment with PQQ significantly inhibited the production of NO and PGE2 and suppressed the expression of pro-inflammatory mediators such as iNOS, COX-2, TNF-a, IL-1b, IL-6, MCP-1 and MIP-1a in LPS treated primary microglia cells.	PQQ Cofactor	47-50	mast cell protease 1	Mus musculus	206-211
25566468-5	2014	RESULTS: During their progress, the mRNA expressions of HIF-1alpha and ERK2 decreased, as did the expression of MCP-1 contained in the nucleus by suppressing oxygen free radicals, which was observed after the exercise program.	oxygen free radicals	158-178	mast cell protease 1	Mus musculus	112-117
24524998-8	2014	However, 5-HT combined with a low dose of 2,4,6-trinitrobenzene sulfonic acid (TNBS), the level of which caused a minimal level of colitis, exaggerated colon inflammation accompanied by much more enhanced induction of inflammatory cytokines, IL-6, IL-8, and MCP-1, indicating that colon epithelial cells directly exposed to 5-HT are primed toward inflammation.	Trinitrobenzenesulfonic Acid	42-77	mast cell protease 1	Mus musculus	258-263
25272503-8	2014	RESULT: Mid and high dose of punicosides reduced the liver index in mice significantly, improved liver steatosis, decreased the level of ALT, AST and TG in serum and the content of MDA in liver homogenate, furthermore the two dose groups increased the activity of SOD, GSH-Px and GSH-ST, inhibited the expression of MCP-1 and NF-kappaB in liver tissue.	punicosides	29-40	mast cell protease 1	Mus musculus	316-321
24886543-7	2014	RESULTS: DHEA was associated with a decrease in the systemic inflammatory response induced by bilateral femoral fracture, especially systemic IL-6 (322.2 vs. 62.5 pg/mL; P = 0.01), IL-1beta (1,422.6 vs. 754.1 pg/mL; P = 0.05), and MCP-1 (219.4 vs. 44.1 pg/mL; P &gt;0.01) levels.	Dehydroepiandrosterone	9-13	mast cell protease 1	Mus musculus	231-236
24524998-8	2014	However, 5-HT combined with a low dose of 2,4,6-trinitrobenzene sulfonic acid (TNBS), the level of which caused a minimal level of colitis, exaggerated colon inflammation accompanied by much more enhanced induction of inflammatory cytokines, IL-6, IL-8, and MCP-1, indicating that colon epithelial cells directly exposed to 5-HT are primed toward inflammation.	Trinitrobenzenesulfonic Acid	79-83	mast cell protease 1	Mus musculus	258-263
24319288-0	2014	Characterization of endocannabinoid-mediated induction of myeloid-derived suppressor cells involving mast cells and MCP-1.	Endocannabinoids	20-35	mast cell protease 1	Mus musculus	116-121
24319288-9	2014	Chemokine analysis of AEA- treated WT mice showed an early spike of MCP-1, which was decreased in Kit(W/W-sh) mice, showing a role of mast cells in the secretion of MCP-1 in response to AEA.	anandamide	22-25	mast cell protease 1	Mus musculus	68-73
24319288-9	2014	Chemokine analysis of AEA- treated WT mice showed an early spike of MCP-1, which was decreased in Kit(W/W-sh) mice, showing a role of mast cells in the secretion of MCP-1 in response to AEA.	anandamide	22-25	mast cell protease 1	Mus musculus	165-170
24319288-9	2014	Chemokine analysis of AEA- treated WT mice showed an early spike of MCP-1, which was decreased in Kit(W/W-sh) mice, showing a role of mast cells in the secretion of MCP-1 in response to AEA.	anandamide	186-189	mast cell protease 1	Mus musculus	165-170
24319288-12	2014	Our studies demonstrate for the first time that endocannaboinids activate CB1 on mast cells to induce MCP-1, which facilitates recruitment of monocytic MDSCs.	endocannaboinids	48-64	mast cell protease 1	Mus musculus	102-107
24437980-6	2014	Another mechanism was that DMC avoided the pancreatic islet dysfunction resulting from cellular damage by suppressing the production of nitric oxide (NO) by iNOS, and the expression of MCP-1.	2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone	27-30	mast cell protease 1	Mus musculus	185-190
24586996-8	2014	PolyICLC administration was associated with increases in TNFalpha, IL6, MCP1, MIP1alpha, KC, and MIP1beta levels in the periphery and with the activation of dendritic cells (DCs), NK cells, and B cells.	poly ICLC	0-8	mast cell protease 1	Mus musculus	72-76
24503166-7	2014	The results showed that CPA significantly increased mice survival rates and down-regulated LPS-induced interleukin (IL)-6, IL-1beta and macrophage chemo-attractant protein (MCP)-1 in serum.	cpa	24-27	mast cell protease 1	Mus musculus	136-179
24690681-6	2014	Moreover, exposure to non-toxic concentrations of thimerosal induced cell cycle arrest in G0/G1 phase of TCR-activated T cells, and inhibition of the release of proinflammatory cytokines such as IFN gamma, IL-1 beta, TNF alpha, IL-2, as well as the chemokine MCP1.	Thimerosal	50-60	mast cell protease 1	Mus musculus	259-263
24529144-14	2014	The LFLC mice that were supplemented with vitamin E for 18 mo had the lowest mRNA expression of inflammatory markers such as VCAM-1, MCP-1 and CD36 in samples obtained from lesion and non-lesionareas.	Vitamin E	42-51	mast cell protease 1	Mus musculus	133-138
24586699-13	2014	Irbesartan significantly suppressed MCP-1 mRNA expression in TNF-alpha stimulated THP-1 monocytes (64.8%+-8.4% of un-treated cells).	Irbesartan	0-10	mast cell protease 1	Mus musculus	36-41
24361309-4	2014	Treatment of RAW 264.7 cells with chicanine down-regulated LPS-induced expression of pro-inflammatory cytokines including TNFalpha, IL-1beta, MCP-1, G-CSF, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	chicanine	34-43	mast cell protease 1	Mus musculus	142-147
24324578-6	2013	Treatment with KB3495 was also associated with a reduction of macrophage content in the atherosclerotic plaques and reduced serum levels of IL-1beta, TNFalpha, IL-6, Interferon gamma, MCP-1 and M-CSF.	kb3495	15-21	mast cell protease 1	Mus musculus	184-189
24088954-8	2014	Losartan also attenuated increased H3K9/14Ac at RAGE, PAI-1, and MCP-1 promoters in mesangial cells cultured under diabetic conditions.	Losartan	0-8	mast cell protease 1	Mus musculus	65-70
24465472-5	2014	After 12 hr, DHA was the most anti-inflammatory, decreasing MCP1 and IL-6 secretion in the contact system (-57%, -63%, respectively, p &lt;= 0.05) with similar effects in the trans-well system.	Dihydroalprenolol	13-16	mast cell protease 1	Mus musculus	60-64
24465472-7	2014	DHA decreased mRNA expression (p&lt;0.05) of Mcp1 (-7.1 fold) and increased expression of the negative regulator, Mcp1-IP (+1.5 fold).	Dihydroalprenolol	0-3	mast cell protease 1	Mus musculus	45-49
24465472-7	2014	DHA decreased mRNA expression (p&lt;0.05) of Mcp1 (-7.1 fold) and increased expression of the negative regulator, Mcp1-IP (+1.5 fold).	Dihydroalprenolol	0-3	mast cell protease 1	Mus musculus	114-118
24465472-10	2014	Overall, our findings suggest that DHA may lessen the degree of MCP1 and IL-6 secreted from adipocytes, and may reduce the degree of M1 polarization of macrophages recruited to adipose tissue, thereby decreasing the intensity of pro-inflammatory cross-talk between adipocytes and macrophages in obese adipose tissue.	Dihydroalprenolol	35-38	mast cell protease 1	Mus musculus	64-68
25376384-11	2014	Expression of the inflammatory mediators NF-kappaB, MCP-1, ICAM-1, iNOS and COX-2 were also decreased with LEC pretreatment of mice injected with Gly.	Glycerol	146-149	mast cell protease 1	Mus musculus	52-57
24124125-6	2014	The OVA-mannose group also had less histamine, MMCP-1, specific IgG, IL-4 and IL-17, and more IL-12p70 (p &lt;= 0.05).	Mannose	8-15	mast cell protease 1	Mus musculus	47-53
24494201-4	2014	UA protected THP-1 monocytes and peritoneal macrophages against metabolic priming and prevented their hyper-reactivity to MCP-1.	ursolic acid	0-2	mast cell protease 1	Mus musculus	122-127
24427330-7	2014	We found that GZ treatment resulted in reduction (i) both amylase and lipase activities, (ii) the serum levels of both MCP-1 and MIP-2; and (iii) markedly attenuated cerulein-induced histopathological alternations and water contents.	Glycyrrhizic Acid	14-16	mast cell protease 1	Mus musculus	119-124
23964117-7	2013	We noticed that all of these signaling molecules, except p38 MAPK and ROS, were indispensable for the induction of MCP-1 and MIP-1alpha.	ros	70-73	mast cell protease 1	Mus musculus	115-120
24055769-4	2013	We found that AI and 6-OAAI inhibit the production of NO, iNOS, and pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1beta, and MCP-1) in LPS-stimulated RAW264.7 macrophages.	austroinulin	14-16	mast cell protease 1	Mus musculus	127-132
24055769-4	2013	We found that AI and 6-OAAI inhibit the production of NO, iNOS, and pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1beta, and MCP-1) in LPS-stimulated RAW264.7 macrophages.	6-O-acetyl-austroinulin	21-27	mast cell protease 1	Mus musculus	127-132
23676336-7	2013	Overall, our findings suggest that epoxides of the omega-3 PUFAs contribute to lowering systolic blood pressure and attenuating inflammation in part by reduced prostaglandins and MCP-1 and by upregulation of angiotensin-converting enzyme-2 in angiotensin-II-dependent hypertension.	Epoxy Compounds	35-43	mast cell protease 1	Mus musculus	179-184
24184481-12	2013	However, MCP-1 and F4/80 mRNA expression levels were significantly attenuated by curcumin administration in downhill running mice.	Curcumin	81-89	mast cell protease 1	Mus musculus	9-14
23852084-9	2013	RESULTS: In HepG2 and 3T3-L1 cells, both H2O2 and aldosterone markedly stimulates the expression of MCP-1, TNFalpha, IL-6, p47 and PU.1 genes.	Hydrogen Peroxide	41-45	mast cell protease 1	Mus musculus	100-105
23676336-6	2013	Our results show that omega-3 rich diet in combination with the sEH inhibitor lowered Ang-II, increased the blood pressure, further increased the renal levels of EPA and DHA epoxides, reduced renal markers of inflammation (ie, prostaglandins and MCP-1), downregulated an epithelial sodium channel, and upregulated angiotensin-converting enzyme-2 message and significantly modulated cyclooxygenase and lipoxygenase metabolic pathways.	omega-3	22-29	mast cell protease 1	Mus musculus	246-251
24055641-8	2013	RESULTS: Helicobacter pylori infection resulted in an increase in ROS and activation of NADPH oxidase and Jak2/Stat3, which induced the expression of MCP-1 and iNOS in AGS cells.	Reactive Oxygen Species	66-69	mast cell protease 1	Mus musculus	150-155
23587398-3	2013	Genistein also significantly suppressed TNF-alpha-induced production of adhesion molecules and chemokines such as sICAM-1, sVCAM-1, sE-Selectin, MCP-1 and IL-8, which play key role in the firm adhesion of monocytes to activated endothelial cells (ECs).	Genistein	0-9	mast cell protease 1	Mus musculus	145-150
23852084-9	2013	RESULTS: In HepG2 and 3T3-L1 cells, both H2O2 and aldosterone markedly stimulates the expression of MCP-1, TNFalpha, IL-6, p47 and PU.1 genes.	Aldosterone	50-61	mast cell protease 1	Mus musculus	100-105
23876538-15	2013	As in vivo experiments, administering parthenolide reduced the number, surface area, and weight, the level of Vegf, Il-6, Mcp-1, and Lif gene expression, and the percentage of Ki67-positive cells in murine endometriosis-like lesions.	parthenolide	38-50	mast cell protease 1	Mus musculus	122-127
23721933-14	2013	Preinjury EtOH treatment was associated with reduced levels of proinflammatory cytokines IL-6, KC, MCP-1, and MIP-1alpha post TBI.	Ethanol	10-14	mast cell protease 1	Mus musculus	99-104
23749168-8	2013	PIP3 supplementation also prevented HG-induced MCP-1 and resistin secretion and lowered adiponectin levels.	PIP3	0-4	mast cell protease 1	Mus musculus	47-52
23436220-8	2013	The concentrations of IL-2, IL-4, GM-CSF, MCP-1 and Rantes in serum, and IL-1alpha in mesenteric lymph node and MIP-1beta in spleen were significantly increased by DON treatment compared to control.	deoxynivalenol	164-167	mast cell protease 1	Mus musculus	42-47
23967184-9	2013	However, niacin treatment attenuated HFD-induced increases in adipose tissue gene expression of MCP-1 and IL-1beta in the wild-type HFD-fed mice.	Niacin	9-15	mast cell protease 1	Mus musculus	96-101
23906708-3	2013	Surfactin significantly suppressed expression of MMP-9, iNOS and COX-2, as well as production of ROS, NO, PGE2, TNF-alpha, IL-1beta, IL-6 and MCP-1 in Abeta-stimulated BV-2 microglial cells.	surfactin peptide	0-9	mast cell protease 1	Mus musculus	142-147
23761083-10	2013	The levels of MCP-1, CCL11, and IL-6 increased after light exposure were suppressed by NAC.	Acetylcysteine	87-90	mast cell protease 1	Mus musculus	14-19
23761083-11	2013	Light-induced MCP-1 and IL-6 were suppressed by Y-27632.	Y 27632	48-55	mast cell protease 1	Mus musculus	14-19
23625200-6	2013	Expression of inflammasome components (NLRP1, NLRP3, ASC) and proinflammatory cytokines (TNF-alpha, MCP-1) was increased in brains of alcohol-fed compared with control mice.	Alcohols	134-141	mast cell protease 1	Mus musculus	100-105
23604472-6	2013	We further examined the influence of asTF overexpression on the expression of MCP-1, Cyr61 and VEGF, as well as on cell number and pro-angiogenic properties of A549 cells.	astf	37-41	mast cell protease 1	Mus musculus	78-83
23536230-10	2013	Diphenyliodonium (DPI), an NOX inhibitor, blocked LPS-induced activation of microglia and production of ROS, TNFalpha, IL-1beta, and MCP-1.	diphenyliodonium	0-16	mast cell protease 1	Mus musculus	133-138
24053909-9	2013	A intensely pulmonary cytokines such as IL-1beta, TNF-alpha, MCP-1 were induced by crystalline silica exposure, and partly inhibited by anti-IL-1beta.	Silicon Dioxide	95-101	mast cell protease 1	Mus musculus	61-66
23604539-6	2013	Both neocuproine treatment and ATP7A deficiency reduced IFN-gamma, MCP-1, MCP-3, and VEGF-A levels.	neocuproine	5-16	mast cell protease 1	Mus musculus	67-72
23604539-6	2013	Both neocuproine treatment and ATP7A deficiency reduced IFN-gamma, MCP-1, MCP-3, and VEGF-A levels.	atp7a	31-36	mast cell protease 1	Mus musculus	67-72
23536230-10	2013	Diphenyliodonium (DPI), an NOX inhibitor, blocked LPS-induced activation of microglia and production of ROS, TNFalpha, IL-1beta, and MCP-1.	diphenyliodonium	18-21	mast cell protease 1	Mus musculus	133-138
23339930-6	2013	The changes 8 h after TPA treatment probably reflected transcriptional regulation, and the genes were divided into three groups, up-regulated (IL-6, MCP-1, HO-1 and SOCS3), unregulated (IL-1beta, TNF-alpha and IL-10) and down-regulated (RANTES) genes.	Tetradecanoylphorbol Acetate	22-25	mast cell protease 1	Mus musculus	149-154
23566810-7	2013	The results showed that icaritin significantly inhibited the NO, IL-6, IL-10 TNF-alpha, and MCP-1 production both in vitro and in vivo.	icaritin	24-32	mast cell protease 1	Mus musculus	92-97
23543756-9	2013	First, sympathetic nerve-derived norepinephrine directly restrains MCP-1 production by peritoneal macrophages during infection.	Norepinephrine	33-47	mast cell protease 1	Mus musculus	67-72
23307012-7	2013	Treatment with H2S decreased IL-1beta, MCP-1, and MIP-2, and increased IL-10 expression in lungs of mice exposed to hyperoxia.	Hydrogen Sulfide	15-18	mast cell protease 1	Mus musculus	39-44
22633994-4	2013	We found that LCWE induced in vitro macrophage activation with increased production of IL-6, TNF-alpha, and MCP-1, concomitantly with Syk activation, and dectin-1 and TLR2 enhancement.	lcwe	14-18	mast cell protease 1	Mus musculus	108-113
22634733-7	2013	However, at the same time point, pretreatment with xanthohumol almost completely blunted the I/R-induced AKT and NFkappaB activation and the expression of the proinflammatory genes IL-1alpha, IL-6, MCP-1 and ICAM-1, which are known to play a crucial role in the subacute phase of I/R-induced liver damage.	xanthohumol	51-62	mast cell protease 1	Mus musculus	198-203
23426399-5	2013	IL-1, IL-3, IL-6, TNF-alpha, TGF-beta, PDGF, MCP-1 and MIP-1 expression were higher in rapamycin-treated mice compared to the control group, however, IGF-1 expression was lower.	Sirolimus	87-96	mast cell protease 1	Mus musculus	45-50
24009860-7	2013	THC also suppressed expression of MCP-1, which plays a key role in the migration of activated microglia.	Dronabinol	0-3	mast cell protease 1	Mus musculus	34-39
23051007-5	2013	Both poly I:C and LPS stimulation in porcine islets induced expression of chemokines (RANTES, MCP-1, IP-10, and IL-8), cytokines (IL-6 and type I interferons), and adhesion molecules (VCAM-1 and ICAM-1).	Poly I-C	5-13	mast cell protease 1	Mus musculus	94-99
23085145-9	2013	Plasma MCP-1 was increased following 5-FU treatment on both days 5 (p=0.10) and 14 (p&lt;0.05).	Fluorouracil	37-41	mast cell protease 1	Mus musculus	7-12
23819050-11	2013	Furthermore, increases in MMPs/TIMPs, fibronectin, type IV collagen, MCP-1, and (P)RR expression, in addition to MAPK and NF- kappa B activity, were significantly attenuated by aliskiren administration.	aliskiren	177-186	mast cell protease 1	Mus musculus	69-74
23437361-7	2013	The expression of IL-6, IL-10, IFNgamma, and MCP-1, key chemokines/cytokines implicated in the development of ALI/ARDS, from both the inflammatory infiltrate and whole lung tissue were modulated by curcumin potentially through a reduction in the phosphorylated form of NFkappaB p65.	Curcumin	198-206	mast cell protease 1	Mus musculus	45-50
22841997-8	2012	In addition to anxiety-like behavior the SDR induced splenomegaly and increase in plasma IL-6, TNFalpha, and MCP-1 were each reversed by pre-treatment with propranolol.	Propranolol	156-167	mast cell protease 1	Mus musculus	109-114
22890994-5	2012	Release of mouse mast cell protease 1 is stimulated by ADP and ATP.	Adenosine Diphosphate	55-58	mast cell protease 1	Mus musculus	17-37
22890994-5	2012	Release of mouse mast cell protease 1 is stimulated by ADP and ATP.	Adenosine Triphosphate	63-66	mast cell protease 1	Mus musculus	17-37
21895782-5	2012	The highest non-cytotoxic concentrations of the ethanolic GSGME dose dependently reduced TNFalpha-induced NF-kappaB transactivation and decreased TNFalpha-induced mRNA levels of the NF-kappaB target genes IL-1beta, IL-8, MCP-1 and CXCL1 in Caco-2 intestinal cells (p &lt; 0.05).	gsgme	58-63	mast cell protease 1	Mus musculus	221-226
22926197-4	2012	Additionally, when nicotine was administered to wild-type mice, it significantly affected the expression of adipokine genes, such as Tnfalpha, AdipoQ, Haptoglobin and Mcp1 in WAT.	Nicotine	19-27	mast cell protease 1	Mus musculus	167-171
22796167-6	2012	Graphene significantly stimulates the secretion of Th1/Th2 cytokines including IL-1alpha, IL-6, IL-10, TNF-alpha and GM-CSF as well as chemokines such as MCP-1, MIP-1alpha, MIP-1beta and RANTES, probably by activating TLR-mediated and NF-kappaB-dependent transcription.	Graphite	0-8	mast cell protease 1	Mus musculus	154-159
22906983-7	2012	At 100 mg/kg, a concentration 10 times higher than that which inhibited PSA in rats, cromolyn significantly inhibited the increases in plasma concentrations of mouse mast cell protease-1 (but not of histamine) during PSA, but had no effect on the reduction in body temperature in this setting.	Cromolyn Sodium	85-93	mast cell protease 1	Mus musculus	166-186
22641092-9	2012	Nilotinib lowered intrahepatic expression of IL-1beta, IL-6, MCP-1, and MIP-2 and systemic levels of IL-6, MCP-1, and TNF.	nilotinib	0-9	mast cell protease 1	Mus musculus	61-66
22641092-9	2012	Nilotinib lowered intrahepatic expression of IL-1beta, IL-6, MCP-1, and MIP-2 and systemic levels of IL-6, MCP-1, and TNF.	nilotinib	0-9	mast cell protease 1	Mus musculus	107-112
22971726-6	2012	The GCV-sensitively tumoricidal activities of SKOV3/tk-MCP-1 with or without monocytes were compared to those of SKOV3 expressing HSV-tk or MCP-1.	Ganciclovir	4-7	mast cell protease 1	Mus musculus	55-60
22820172-5	2012	KEY FINDING: Concurrent use of cilostazol and MTX effectively suppressed proliferation and cell viability associated with enhanced apoptosis of synovial fibroblasts and significantly suppressed cytokine production, including TNF-alpha, IL-1beta, IL-6, and MCP-1 in an additive manner.	Cilostazol	31-41	mast cell protease 1	Mus musculus	256-261
22820172-5	2012	KEY FINDING: Concurrent use of cilostazol and MTX effectively suppressed proliferation and cell viability associated with enhanced apoptosis of synovial fibroblasts and significantly suppressed cytokine production, including TNF-alpha, IL-1beta, IL-6, and MCP-1 in an additive manner.	Methotrexate	46-49	mast cell protease 1	Mus musculus	256-261
22971726-8	2012	RESULTS: The significant GCV-sensitively tumoricidal activity of pLXSN/tk-MCP-1 was observed when compared with those of pLXSN/tk, pLXSN/MCP-1 and pLXSN/neo, especially when monocytes were added.	Ganciclovir	25-28	mast cell protease 1	Mus musculus	74-79
22753217-8	2012	Inhibition of HO activity by administration of tin mesoporphyrin to HF-fed mice transduced with the aP2-HO-1 reversed the decrease in Peg1/Mesoderm-specific transcript, TNFalpha, and MCP-1 levels.	tin mesoporphyrin	47-64	mast cell protease 1	Mus musculus	183-188
25780643-13	2012	The ZnO NP HPPS, however, significantly activated NF-kappa B and up-regulated its dependent genes such as TNF-alpha, IL-1, and MCP-1.	Zinc Oxide	4-7	mast cell protease 1	Mus musculus	127-132
22920325-6	2012	The levels of inflammatory cytokines including TNF-alpha and MCP-1 were also significantly decreased with sulindac treatment, as well as the expression of TGF-beta, PDGF-beta, SHH and Gli in the chronic pancreatic tissue detected by qPCR assay and confirmed by western blot assay.	Sulindac	106-114	mast cell protease 1	Mus musculus	61-66
22913271-8	2012	Similarly, 6-week feeding of low-dose resveratrol combined with either leucine or its metabolite HMB to DIO mice increased adipose Sirt1 activity, muscle glucose and palmitate uptake (measured via PET/CT), insulin sensitivity (HOMAIR), improved inflammatory stress biomarkers (CRP, IL-6, MCP-1, adiponectin) and reduced adiposity comparable to the effects of high dose resveratrol, while low-dose resveratrol exerted no independent effect.	Resveratrol	38-49	mast cell protease 1	Mus musculus	288-293
22913271-8	2012	Similarly, 6-week feeding of low-dose resveratrol combined with either leucine or its metabolite HMB to DIO mice increased adipose Sirt1 activity, muscle glucose and palmitate uptake (measured via PET/CT), insulin sensitivity (HOMAIR), improved inflammatory stress biomarkers (CRP, IL-6, MCP-1, adiponectin) and reduced adiposity comparable to the effects of high dose resveratrol, while low-dose resveratrol exerted no independent effect.	Leucine	71-78	mast cell protease 1	Mus musculus	288-293
22728094-7	2012	Ar-turmerone also reduced TNF-alpha, IL-1beta, IL-6, and MCP-1 production in Abeta-stimulated microglial cells.	ar-turmerone	0-12	mast cell protease 1	Mus musculus	57-62
23105977-7	2012	Intranasal rapamycin attenuated lung MCP-1, IL-2, IL-6, and IFNgamma by 70%, 30%, 64%, and 68% respectively.	Sirolimus	11-20	mast cell protease 1	Mus musculus	37-42
22683874-9	2012	Western blot analyses showed increased MCP-1 and iNOS expression in EtOH group, which was significantly inhibited by DEC treatment.	Ethanol	68-72	mast cell protease 1	Mus musculus	39-44
22621868-5	2012	Furthermore, in the adipose tissue, Tb reduced the expression of MCP-1 and infiltration by leukocytes and restored the production of adiponectin.	tributyrin	36-38	mast cell protease 1	Mus musculus	65-70
23034257-12	2012	The two hypoxia-inducing conditions (CoCl2 and 1 percent O2) produced different outcomes in metabolic measurements as well as in the expression of some genes (GLUT-1, ANPGTL4, PPAR-gamma and adiponectin), while it remained similar in others (HIF-1alpha, IL-6 and MCP-1).	Oxygen	57-59	mast cell protease 1	Mus musculus	263-268