PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 7936653-6 1994 Treatment of thymus and spleen extracts with deoxycholate (DOC), however, results in a strong increase in binding to kappa B sites of both RelA and c-Rel complexes. Deoxycholic Acid 45-57 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 139-143 7936653-6 1994 Treatment of thymus and spleen extracts with deoxycholate (DOC), however, results in a strong increase in binding to kappa B sites of both RelA and c-Rel complexes. Deoxycholic Acid 59-62 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 139-143 33765609-7 2021 Furthermore, NaHS or SAMe restored the SIRT1 level and the phosphorylation of mTOR and NF-kappaB p65 disturbed by high glucose in HT-22 cells, suggesting H2S reversed high glucose-induced alteration of SIRT1-mTOR/NF-kappaB signaling pathway. Deuterium 154-157 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 97-100 8035813-3 1994 NF-kappa B p50/p65 is the major inducible nuclear complex after lipopolysaccharide or phorbol myristate acetate treatment of 70Z/3 cells. Tetradecanoylphorbol Acetate 86-111 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 15-18 8497281-5 1993 Within 5 h after exposure to phosphorothio antisense p65 oligonucleotides, cells exhibited dramatic alterations in adhesion properties. phosphorothio 29-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 8497281-5 1993 Within 5 h after exposure to phosphorothio antisense p65 oligonucleotides, cells exhibited dramatic alterations in adhesion properties. Oligonucleotides 57-73 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 8497281-6 1993 Similar findings were obtained in a stable cell line that expressed a dexamethasone-inducible antisense mRNA to p65. Dexamethasone 70-83 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 112-115 8497281-7 1993 Although antisense oligonucleotides raised against both p50 and p65 elicited a significant reduction in their respective mRNAs, only the cells treated with antisense p50 maintained a normal morphology. Oligonucleotides 19-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-67 8497281-9 1993 The ability of the individual antisense oligonucleotides to elicit differential effects on cell adhesion, a property dependent upon the stage of differentiation, suggests that the p50 and p65 subunits of NF-kappa B regulate gene expression either as homodimers or as heterodimers with other rel family members. Oligonucleotides 40-56 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 188-191 8155973-0 1993 A sense phosphorothioate oligonucleotide directed to the initiation codon of transcription factor NF-kappa B p65 causes sequence-specific immune stimulation. Phosphorothioate Oligonucleotides 8-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-112 8155973-4 1993 We have shown that phosphorothioate antisense oligonucleotides to the p65 subunit of NF-kappa B, a transcription factor, cause a block in cell adhesion. Parathion 19-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 8155973-4 1993 We have shown that phosphorothioate antisense oligonucleotides to the p65 subunit of NF-kappa B, a transcription factor, cause a block in cell adhesion. Oligonucleotides 46-62 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 8155973-5 1993 In our efforts to test the efficacy of NF-kappa B p65 oligonucleotides in vivo, we unexpectedly observed that the control p65-sense, but not the p65-antisense, oligonucleotides caused massive splenomegaly in mice. Oligonucleotides 54-70 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 50-53 8155973-5 1993 In our efforts to test the efficacy of NF-kappa B p65 oligonucleotides in vivo, we unexpectedly observed that the control p65-sense, but not the p65-antisense, oligonucleotides caused massive splenomegaly in mice. Oligonucleotides 54-70 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-125 8155973-5 1993 In our efforts to test the efficacy of NF-kappa B p65 oligonucleotides in vivo, we unexpectedly observed that the control p65-sense, but not the p65-antisense, oligonucleotides caused massive splenomegaly in mice. Oligonucleotides 54-70 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-125 8155973-5 1993 In our efforts to test the efficacy of NF-kappa B p65 oligonucleotides in vivo, we unexpectedly observed that the control p65-sense, but not the p65-antisense, oligonucleotides caused massive splenomegaly in mice. Oligonucleotides 160-176 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 50-53 8155973-5 1993 In our efforts to test the efficacy of NF-kappa B p65 oligonucleotides in vivo, we unexpectedly observed that the control p65-sense, but not the p65-antisense, oligonucleotides caused massive splenomegaly in mice. Oligonucleotides 160-176 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-125 8155973-5 1993 In our efforts to test the efficacy of NF-kappa B p65 oligonucleotides in vivo, we unexpectedly observed that the control p65-sense, but not the p65-antisense, oligonucleotides caused massive splenomegaly in mice. Oligonucleotides 160-176 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-125 8155973-6 1993 In the current study we demonstrate a sequence-specific stimulation of splenic cell proliferation, both in vivo and in vitro, by treatment with p65-sense oligonucleotides. Oligonucleotides 154-170 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 144-147 8155973-8 1993 The secretion of immunoglobulins by the p65-sense oligonucleotide-treated splenocytes is also enhanced. Oligonucleotides 50-65 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-43 7950306-0 1994 In vivo toxicological effects of rel A antisense phosphorothioates in CD-1 mice. Parathion 49-66 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-38 8031318-9 1994 Three cellular proteins (p65, p70, and p72) seemed most susceptible to inhibition by THC. Dronabinol 85-88 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 25-28 8254739-6 1994 One sequence motif is shown to constitutively bind CREB- and Jun-related proteins in both keratinocytes and fibroblasts, whereas the other is a target for TPA-induced c-Rel/p65(NF-kappa B)-binding activity specifically in keratinocytes. Tetradecanoylphorbol Acetate 155-158 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 173-176 8234333-5 1993 In diverse transformed cell lines, phosphorothioate antisense oligonucleotides to p65 inhibited in vitro growth, reduced soft-agar colony formation, and eliminated the ability of cells to adhere to an extracellular matrix. Parathion 35-51 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 8234333-5 1993 In diverse transformed cell lines, phosphorothioate antisense oligonucleotides to p65 inhibited in vitro growth, reduced soft-agar colony formation, and eliminated the ability of cells to adhere to an extracellular matrix. Oligonucleotides 62-78 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 8234333-6 1993 Stable transfectants of a fibrosarcoma cell line expressing dexamethasone-inducible antisense RNA to p65 showed inhibition of in vitro growth and in vivo tumor development. Dexamethasone 60-73 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 1841270-0 1991 Antisense oligodeoxynucleoside methylphosphonate inhibition of mouse c-myc p65 protein expression in E mu-c-myc transgenic mice. oligodeoxynucleoside methylphosphonate 10-48 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 75-78 1841270-3 1991 Finally, methylphosphonate oligomers targeted against c-myc mRNA inhibited production of c-myc p65 protein in peripheral and splenic lymphocytes, relative to a scrambled sequence oligomer, 4 hours after injection of a 300 nmol dose, as indicated by immunofluorescence of fixed cells stained with an anti-c-myc antiserum. methylphosphonic acid 9-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-98 33765609-7 2021 Furthermore, NaHS or SAMe restored the SIRT1 level and the phosphorylation of mTOR and NF-kappaB p65 disturbed by high glucose in HT-22 cells, suggesting H2S reversed high glucose-induced alteration of SIRT1-mTOR/NF-kappaB signaling pathway. sodium bisulfide 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 97-100 33765609-7 2021 Furthermore, NaHS or SAMe restored the SIRT1 level and the phosphorylation of mTOR and NF-kappaB p65 disturbed by high glucose in HT-22 cells, suggesting H2S reversed high glucose-induced alteration of SIRT1-mTOR/NF-kappaB signaling pathway. Glucose 119-126 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 97-100 33800441-6 2021 In the NF-kappaB signaling pathway, Schisandrol A suppressed the degradation of IkappaB and the phosphorylation of p65 induced by IL-1beta. schisandrol A 36-49 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 115-118 32795892-6 2020 We found that Abeta caused p65 nuclear translocation in both primary microglial cells and astrocytes, which were, however, restrained by CZ treatments. Chlorzoxazone 137-139 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 27-30 32795892-14 2020 We finally found that hippocampal glial activation in AD mice was obviously blocked by CZ supplementation, along with remarkable decreases in TNF-alpha, IL-1beta and p65 nuclear translocation. Chlorzoxazone 87-89 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 166-169 30853175-5 2019 Furthermore, we found that PMMA induction could directly cause the phosphorylation of IkappaB and significantly promote the nuclear translocation of p65 in RAW264.7 cells. Polymethyl Methacrylate 27-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 149-152 30853175-7 2019 In vivo, PR was observed to attenuate PMMA-induced osteoclastogenesis, osteolysis, mRNA expressions of receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) and RANK, as well as protein levels of MMP-9, TNF-alpha, IL-6, and p65 in a murine calvarial osteolysis model. Polymethyl Methacrylate 38-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 234-237 30853175-6 2019 In other words, PR was able to dose-dependently attenuate the PMMA-induced nuclear translocation of p65 in RAW264.7 cells. Polymethyl Methacrylate 62-66 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 100-103 24147349-0 2013 A new ligustrazine derivative--pharmacokinetic evaluation and antitumor activity by suppression of NF-kappaB/p65 and COX-2 expression in S180 mice. tetramethylpyrazine 6-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-112 19453757-7 2009 Signal transduction studies showed that avermectin significantly inhibits NF-kappaB p65 translocation into the nucleus and inhibits JNK and p38 phosphorylation protein expression. avermectin 40-50 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 34416296-12 2022 CCI induced an increase in the expression of TLR4 and p-P65 in microglia, whereas QFZTC dose-dependently reduced the expression of Iba-1, TLR4, MyD88, and p-P65 in the spinal cord. CCI 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 56-59 34784237-6 2022 In J774A.1 cells induced by LPS alone, paeonol reduced the levels of IL-1beta, NLRP3, p-IKK, p-IkappaBalpha, and p-p65, but did not affect ASC levels. paeonol 39-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 115-118 34784237-7 2022 Paeonol also promoted the content of IkappaBalpha and retained more p65 in the cytoplasm. paeonol 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 34784237-8 2022 Furthermore, paeonol reduced the DNA-binding activity of p65 and lowered the levels of p-JNK, p-ERK, and p-p38. paeonol 13-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 57-60 34463846-8 2022 In vitro, PQ exposure also increased the expressions of TLR4, NF-kappaB p65, and TGF-beta1 in A549 cells, but knocking down TNC gene expression obviously down-regulated the expressions of TLR4, NF-kappaB p65, NF-kappaB Pp65, and TGF-beta1. Paraquat 10-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 204-207 25435215-7 2015 Subsequently, we demonstrated that overexpression of CRY1 inhibited the basal concentration of cyclic adenosine monophosphate (cAMP), leading to decreased protein kinase A activity, which resulted in decreased phosphorylation of p65. Cyclic AMP 95-125 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 229-232 25435215-7 2015 Subsequently, we demonstrated that overexpression of CRY1 inhibited the basal concentration of cyclic adenosine monophosphate (cAMP), leading to decreased protein kinase A activity, which resulted in decreased phosphorylation of p65. Cyclic AMP 127-131 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 229-232 34954266-16 2022 The results of molecular docking showed that dioscin and pseudoprotodioscin were the top two compounds of DXXK, which had high affinity with HIF-1alpha and NF-kappaB p65. dioscin 45-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 166-169 34954266-16 2022 The results of molecular docking showed that dioscin and pseudoprotodioscin were the top two compounds of DXXK, which had high affinity with HIF-1alpha and NF-kappaB p65. pseudo-protodioscin 57-75 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 166-169 34710452-6 2022 Exercise decreased the mRNA expressions of IL-1beta, IL-6, TNF-alpha, TLR2 and NF-kappaB (p65) in fluoride-exposed mice, and restored the gene levels of Occludin and ZO-1 in the duodenum, as well as Occludin, ZO-1, and Claudin-1 in the colon. Fluorides 98-106 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-93 34953939-13 2022 In addition, the absence of Nrf2 abolished the suppressive effect of hydrogen on the expression of Nacht, Lrr, and Pyd domains-containing protein 3 (NLRP3) pathway members and p65 NF-kappaB after HI. Hydrogen 69-77 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 176-189 34968779-8 2022 Western blot was utilized to determine the effect of Ginsenoside Compound K on the nuclear factor-kappaB (NF-kappaB) p65 nuclear translocation. Ginsenosides 53-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-120 34968779-10 2022 RESULTS: Ginsenoside Compound K diminished inflammatory cytokine production and reversed NF-kappaB p65 nuclear translocation induced by Abeta42 oligomers. Ginsenosides 9-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-102 34253875-6 2022 We showed that wogonin (4, 8, 16 muM) dose-dependently alleviated high glucose (HG)-induced MPC5 cell damage, accompanied by increased expression of WT-1, nephrin, and podocin proteins, and decreased expression of TNF-alpha, MCP-1, IL-1beta as well as phosphorylated p65. wogonin 15-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 267-270 34253875-14 2022 We showed that wogonin administration significantly alleviated albuminuria, histopathological lesions, and p65 NF-kappaB-mediated renal inflammatory response. wogonin 15-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-120 34915410-0 2022 Dimethyl fumarate attenuates LPS induced septic acute kidney injury by suppression of NFkappaB p65 phosphorylation and macrophage activation. Dimethyl Fumarate 0-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-98 34960054-6 2021 In addition, DMEE reduced the release of proinflammatory cytokines, mainly IL-6 and IL-1beta, in RAW 264.7 cells by inhibiting the phosphorylation of JNK, ERK and p65. dmee 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 163-166 34934622-12 2021 In ATDC5 cells, we could observe the high glucose up-regulated the P50 and P65 expressions and down-regulated IkappaBalpha expression, but the high glucose-activated NF-kappaB signaling could be reversed by addition of Bay (inhibitor of NF-kappaB signaling). Glucose 42-49 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 75-78 34908863-12 2021 Furthermore, in cultured dorsal root ganglion neurons, estrogen at physiological concentration elevated intracellular Mg2+, and downregulated phospho-p65, tumor necrosis factor-alpha and interleukin-1 beta exclusively in the presence of extracellular Mg2+. magnesium ion 251-255 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 150-153 34934622-12 2021 In ATDC5 cells, we could observe the high glucose up-regulated the P50 and P65 expressions and down-regulated IkappaBalpha expression, but the high glucose-activated NF-kappaB signaling could be reversed by addition of Bay (inhibitor of NF-kappaB signaling). Glucose 148-155 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 75-78 34607110-0 2021 The natural product vioprolide A exerts anti-inflammatory actions through inhibition of its cellular target NOP14 and downregulation of importin-dependent NF-kB p65 nuclear translocation. Vioprolide A 20-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 161-164 34713618-5 2021 Mechanistically, 4HBP exposure activates protein kinase R-like ER kinase (PERK) signaling, which induces CHOP, inhibits IkappaB translation, and transactivates p65, thereby promoting inflammation and apoptosis on multiple levels. 4-hydroxybenzophenone 17-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 160-163 34758665-3 2021 Our study aimed to investigate the mechanisms of hepatotoxicity treated with TP in vivo and in vitro, as well as their relationship with the NF-kappaB (p65) signal pathway; and to assess TP-induced hepatotoxicity after CYP2E1 modulation by the known inhibitor, clomethiazole, and the known inducer, pyrazole. triptolide 77-79 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 152-155 34747340-12 2021 In addition, miR-125-5p up-regulation significantly reduced the expression of IL-6 R in the UC mice, and reduced the expression levels of JAK1, STAT3 and p65 phosphorylation. mir-125-5p 13-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 154-157 34416495-4 2021 Our results showed that HFPO-DA exposure caused colonic inflammation which was coupled with increased TNF-alpha levels in serum and increased mRNA expression levels of TNF-alpha, p65, TLR4, MCP-1 of the colon in mice after exposure to 200 mug/L HFPO-DA. perfluorooctane 24-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 179-182 34416495-4 2021 Our results showed that HFPO-DA exposure caused colonic inflammation which was coupled with increased TNF-alpha levels in serum and increased mRNA expression levels of TNF-alpha, p65, TLR4, MCP-1 of the colon in mice after exposure to 200 mug/L HFPO-DA. perfluorooctane 245-252 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 179-182 34659514-9 2021 Furthermore, the levels of IL-6, cyclooxygenase-2, TNF-alpha and p65 were reduced after administration of DHEP. diclofenac hydroxyethylpyrrolidine 106-110 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 65-68 34758665-8 2021 In addition, TP can promote oxidative stress, inflammatory and involving the NF-kappaB (p65) signal pathway. triptolide 13-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 34810128-6 2021 In vitro, we found that citrate treatment significantly augmented the expression of NLRP3 and pro-IL-1beta and enhanced the translocation of NF-kappaB/p65 into the nucleus. Citric Acid 24-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 151-154 34784210-5 2021 It was also observed that l-theanine treatment downregulated the levels of p-p65, p65, p-p53, p53, and p-AKT protein expression in acute DSS-induced colitis, which showed the protective function of l-theanine, mainly via the NF-kappaB signaling pathway. theanine 26-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-80 34784210-5 2021 It was also observed that l-theanine treatment downregulated the levels of p-p65, p65, p-p53, p53, and p-AKT protein expression in acute DSS-induced colitis, which showed the protective function of l-theanine, mainly via the NF-kappaB signaling pathway. theanine 26-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 34784210-5 2021 It was also observed that l-theanine treatment downregulated the levels of p-p65, p65, p-p53, p53, and p-AKT protein expression in acute DSS-induced colitis, which showed the protective function of l-theanine, mainly via the NF-kappaB signaling pathway. theanine 198-208 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-80 34784210-5 2021 It was also observed that l-theanine treatment downregulated the levels of p-p65, p65, p-p53, p53, and p-AKT protein expression in acute DSS-induced colitis, which showed the protective function of l-theanine, mainly via the NF-kappaB signaling pathway. theanine 198-208 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 34806822-8 2022 Emodin significantly decreased CLP-induced cell apoptosis, upregulated expression of sirtuin 1 (SIRT1), and inhibited p-p65/p65 and HMGB1. Emodin 0-6 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 124-127 34192357-6 2021 We found that these vitamin D effects were accompanied by decreased NF-kappaB (p65) in the knockout intestinal epithelia, reduced tissue-resident macrophages, and partial restoration of epithelial morphology. Vitamin D 20-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 79-82 34460994-15 2021 Th17/Treg ratio was imbalanced, RORgammat and IL-17 were upregulated, and Foxp 3, IL-10, and TGF-beta1 were downregulated after OVA sensitization, while vitamin D treatment inverted these changes and inhibited the NF-kappaB-p65 phosphorylation level. Vitamin D 153-162 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 224-227 34624494-6 2021 Furthermore, DPTM inhibited the translocation of p-65 to nucleus in RAW264.7 cells infected by MRSA. dptm 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 49-53 34880751-0 2021 Cinacalcet Targets the Neurokinin-1 Receptor and Inhibits PKCdelta/ERK/P65 Signaling to Alleviate Dextran Sulfate Sodium-Induced Colitis. Cinacalcet 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 71-74 34880751-8 2021 In vitro studies revealed that cinacalcet suppressed the translocation of P65 and inhibited production of the inflammatory cytokines IL-1beta and IL-6. Cinacalcet 31-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-77 34880751-10 2021 Furthermore, the inhibition of NK-kappaB P65 activation was found to occur via the suppression of PKCdelta/ERK/P65 signaling mediated by cinacalcet. Cinacalcet 137-147 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 111-114 34880751-11 2021 Conclusion: Cinacalcet inhibits the activation of NF-kappaB and reduces the production of inflammatory cytokines by suppressing the PKCdelta/ERK/P65 signaling pathway via targeting NK1R, suggesting that it can be used to treat inflammatory diseases, particularly colitis. Cinacalcet 12-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 145-148 34672194-8 2021 Furthermore, EA significantly inhibited the expressions of XOD and NLRP3 pathway-related proteins (TLR4, p-p65, caspase-1, TNF-alpha, and IL-18) in vitro and in vivo. Ellagic Acid 13-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-110 34757554-8 2022 In addition, SNI-induced pain was reversed by intraperitoneal administration of THP, and further results indicated that THP suppressed inducible nitric oxide synthase (iNOS, pro-nociceptive mediators), phosphorylated MAPKs, and p65 in the dorsal root ganglions and sciatic nerve, while the serum levels of the pro-inflammatory cytokines IL-1beta were significantly higher in the SNI group as compared to the THP group. tetrahydropalmatine 80-83 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 228-231 34757554-8 2022 In addition, SNI-induced pain was reversed by intraperitoneal administration of THP, and further results indicated that THP suppressed inducible nitric oxide synthase (iNOS, pro-nociceptive mediators), phosphorylated MAPKs, and p65 in the dorsal root ganglions and sciatic nerve, while the serum levels of the pro-inflammatory cytokines IL-1beta were significantly higher in the SNI group as compared to the THP group. tetrahydropalmatine 120-123 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 228-231 34757554-8 2022 In addition, SNI-induced pain was reversed by intraperitoneal administration of THP, and further results indicated that THP suppressed inducible nitric oxide synthase (iNOS, pro-nociceptive mediators), phosphorylated MAPKs, and p65 in the dorsal root ganglions and sciatic nerve, while the serum levels of the pro-inflammatory cytokines IL-1beta were significantly higher in the SNI group as compared to the THP group. tetrahydropalmatine 408-411 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 228-231 34757554-10 2022 In vitro experiments indicated that THP suppressed the expression of IL-1beta, iNOS, phosphorylated MAPKs, and p65, which were assayed using western blotting, and immunofluorescence. tetrahydropalmatine 36-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 111-114 34869093-10 2021 Hydrogen inhibited the NF-kappaB p65 in M1 macrophages nucleus and distal ileum of NEC. Hydrogen 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-36 34824589-10 2021 Moreover, AU blocked IkappaB and p65 phosphorylation, and p65 nuclear translocation. aurapten 10-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-36 34824589-10 2021 Moreover, AU blocked IkappaB and p65 phosphorylation, and p65 nuclear translocation. aurapten 10-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 58-61 34824670-7 2021 In addition, the results indicated that vitamin D3 could significantly reduce the phosphorylation level of NF-kappaB (p65) and enhance the expression of Nrf2 and HO-1 in the jejunum compared with the diquat-induced group. Cholecalciferol 40-50 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-121 34824670-7 2021 In addition, the results indicated that vitamin D3 could significantly reduce the phosphorylation level of NF-kappaB (p65) and enhance the expression of Nrf2 and HO-1 in the jejunum compared with the diquat-induced group. Diquat 200-206 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-121 34824670-8 2021 This study suggested that oral administration of vitamin D3 can protect mice against oxidative damage by inhibiting the phosphorylation level of NF-kappaB (p65) and activating Nrf2-related signaling pathways. Cholecalciferol 49-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 156-159 34764323-9 2021 In vivo expression of NF-kappaB targets such as OSX, OCN, PTX3 and p65 in odontoblasts and dental pulp cells from DSPP null mouse was lower when compared with the wild-type. dspp 114-118 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 67-70 34510720-6 2021 Moreover, curcumin supplementation reduced expression of other key pro-inflammatory genes, such as NF-kappaB p65 subunit (p65), Stat1, Tlr4, and Il6, in WAT (p<0.05). Curcumin 10-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-126 34649343-12 2021 LPS stimulation dramatically activated NF-kappaB signal pathway, indicated by increased expressions of phosphorylation of p65 (p-p65), p-IKKalpha/beta and p-IkappaBalpha and the higher p65-DNA binding activity, which were all dose-dependently reversed by Andro-S. Sulfur 260-262 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 185-188 34764958-17 2021 Alda-1 significantly decreased the WBH-induced accumulation of 4-HNE and p65 and p38 activation. Alda-1 0-6 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-76 34764958-17 2021 Alda-1 significantly decreased the WBH-induced accumulation of 4-HNE and p65 and p38 activation. wbh 35-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-76 34721040-10 2021 In mechanism, betulin activated the AKT/Nrf2 pathway and inhibited the phosphorylation of p65. betulin 14-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-93 34689333-7 2022 Moreover, fucoidan down-regulated the TLR4/NF-kappaB pathway, as indicated by decreased levels of TLR4, NF-kappaB p65, NF-kappaB p50, and increased IkappaBalpha level in liver and kidney tissues. fucoidan 10-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-117 34822458-6 2021 Then, DPA inhibited the activation of mitogen-activated protein kinase (MAPK) p38 and nuclear factor-kappaB (NF-kappaB) p65 pathways, which results were similar to the effects of NF-kappaB inhibitor, a positive control. docosapentaenoic acid 6-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 120-123 34681815-6 2021 Both dextran sulfate sodium- and 2, 4, 6-trinitrobenzene sulfonic acid-induced murine IBD models revealed that orally delivered fexofenadine was therapeutic against IBD, evidenced by mitigated clinical symptoms, decreased secretions of the proinflammatory cytokine IL-6 and IL-1beta, lowered intestinal inflammation, and reduced p-p65 and p-IkBalpha. fexofenadine 128-140 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 331-334 34364303-8 2021 Mechanismly, nilotinib inhibited NF-kappaB signaling pathway and suppressed the nuclear translocation of p65 upon LPS stimulation. nilotinib 13-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 105-108 34181194-9 2021 Triptolide (a specific p65 inhibitor) reversed p65 activation and ameliorated PM2.5-induced airway inflammation and bronchial hyperresponsiveness. triptolide 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 23-26 34181194-9 2021 Triptolide (a specific p65 inhibitor) reversed p65 activation and ameliorated PM2.5-induced airway inflammation and bronchial hyperresponsiveness. triptolide 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 47-50 34606539-7 2021 Western blot analysis showed that L. plantarum HM-22 significantly increased the expression of occludin and claudin-1 in the colon of alpha-LA-induced allergic mice and decreased the expression of the inflammatory proteins p65 and IkappaBalpha (p < 0.05). hm-22 47-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 223-226 34426115-7 2021 While, in mice receiving the oral administration of terpinen4-ol, the production of TNF-alpha, IL-10, TLR4, and p65 was suppressed on day 1, 7, and 14 of heat stress. terpinenol-4 52-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 112-115 34390195-7 2021 We further determine that the activation of SIGNR1/phospho-c-Raf (S338)/phospho-p65 (S276)/acetyl-p65 (K310) pathway is responsible for KMOS-induced AAM/M2 polarization. kmos 136-140 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 80-83 34181194-11 2021 Triptolide inhibition of p65 phosphorylation and acetylation could be an effective therapeutic approach in averting PM2.5-induced airway inflammation and bronchial hyperresponsiveness. triptolide 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 25-28 34580236-10 2021 Small molecule-protein docking and co-immunoprecipitation (Co-IP) were used to verify the targeted binding relationship between Gal B and P65. gal b 128-133 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 138-141 34435401-0 2021 Therapeutic potential of isobavachalcone, a natural flavonoid, in murine experimental colitis by inhibiting NF-kappaB p65. isobavachalcone 25-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-121 34580236-15 2021 CONCLUSION: Gal B could target the P65 protein. gal b 12-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 35-38 34552216-11 2021 Importantly, DHC attenuated LPS-induced activation of p65 and the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway. dehydrocorydalin 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 54-57 34646242-0 2021 relA Inactivation Converts Sulfonamides Into Bactericidal Compounds. Sulfonamides 27-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 0-4 34646242-3 2021 Here we show that, deleting relA in Escherichia coli and other bacterial species converted sulfamethoxazole from a bacteriostat into a bactericide. Sulfamethoxazole 91-107 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 28-32 34646242-5 2021 When E. coli relA was treated with SMX, reactive oxygen species and ferrous ion accumulated inside the bacterial cells, which caused extensive DNA double-strand breaks without the involvement of incomplete base excision repair. Sulfamethoxazole 36-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 14-18 34646242-5 2021 When E. coli relA was treated with SMX, reactive oxygen species and ferrous ion accumulated inside the bacterial cells, which caused extensive DNA double-strand breaks without the involvement of incomplete base excision repair. Reactive Oxygen Species 41-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 14-18 34646242-5 2021 When E. coli relA was treated with SMX, reactive oxygen species and ferrous ion accumulated inside the bacterial cells, which caused extensive DNA double-strand breaks without the involvement of incomplete base excision repair. ammonium ferrous sulfate 69-80 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 14-18 34646242-6 2021 In addition, sulfamethoxazole showed bactericidal effect against E. coli O157 relA in mice, suggesting the possibility of designing new potentiators for sulfonamides targeting RelA. Sulfamethoxazole 13-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 79-83 34646242-6 2021 In addition, sulfamethoxazole showed bactericidal effect against E. coli O157 relA in mice, suggesting the possibility of designing new potentiators for sulfonamides targeting RelA. Sulfamethoxazole 13-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 177-181 34646242-6 2021 In addition, sulfamethoxazole showed bactericidal effect against E. coli O157 relA in mice, suggesting the possibility of designing new potentiators for sulfonamides targeting RelA. Sulfonamides 154-166 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 79-83 34646242-6 2021 In addition, sulfamethoxazole showed bactericidal effect against E. coli O157 relA in mice, suggesting the possibility of designing new potentiators for sulfonamides targeting RelA. Sulfonamides 154-166 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 177-181 34552216-12 2021 Thus, we conclude that DHC ameliorates atherosclerosis in ApoE-/- mice by inhibiting inflammation, likely by targeting macrophage p65- and ERK1/2-mediated pathways. dehydrocorydalin 23-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 130-133 34603071-12 2021 Further, the activations of HSCs and TLR4 signaling pathway were observed after DSS + CCl4 treatment, presenting with the increase in expression of alpha-SMA, vimentin, TGF-beta, collagen type I, collagen type II, TIMP-2, TLR4, TRAF6, and NF-kappaB p65, and a decrease in GFAP and MMP-2 expression. Dextran Sulfate 80-83 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 249-252 34482357-9 2021 In addition, LCBE treatment improved the liver function and lipid profile, decreased the levels of LPS and inflammatory cytokines, and downregulated the expression of TLR4 and NF-kappaB p65. lcbe 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 186-189 34271152-5 2021 In this study, an amphiphilic cationic cyclodextrin (CD) nanoparticle modified with PEGylated folate (FA; a ligand to target folate receptor on CRC) has been developed for co-delivery of DTX and siRNA (against the RelA, a subunit of NF-kappaB) in the treatment of CRC. Cyclodextrins 39-51 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 214-218 34271152-5 2021 In this study, an amphiphilic cationic cyclodextrin (CD) nanoparticle modified with PEGylated folate (FA; a ligand to target folate receptor on CRC) has been developed for co-delivery of DTX and siRNA (against the RelA, a subunit of NF-kappaB) in the treatment of CRC. Cyclodextrins 53-55 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 214-218 34271152-7 2021 The CD.DTX.siRelA.PEG-FA nanoparticle enhanced the apoptotic effect of DTX with the downregulation of RelA expression, which significantly retarded the growth of CRC in mice, without causing significant toxicity. Cyclodextrins 4-6 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-106 34271152-7 2021 The CD.DTX.siRelA.PEG-FA nanoparticle enhanced the apoptotic effect of DTX with the downregulation of RelA expression, which significantly retarded the growth of CRC in mice, without causing significant toxicity. Docetaxel 7-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-106 34271152-7 2021 The CD.DTX.siRelA.PEG-FA nanoparticle enhanced the apoptotic effect of DTX with the downregulation of RelA expression, which significantly retarded the growth of CRC in mice, without causing significant toxicity. poly(ethylene glycol)-folate 18-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-106 34271152-7 2021 The CD.DTX.siRelA.PEG-FA nanoparticle enhanced the apoptotic effect of DTX with the downregulation of RelA expression, which significantly retarded the growth of CRC in mice, without causing significant toxicity. Docetaxel 71-74 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-106 34580604-7 2021 In cultured glomerular mesangial cells, high glucose- (HG-) induced p65 phosphorylation and COX-2 expression were attenuated by PP2 or NF-kappaB inhibitor PDTC. Glucose 45-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 34580604-7 2021 In cultured glomerular mesangial cells, high glucose- (HG-) induced p65 phosphorylation and COX-2 expression were attenuated by PP2 or NF-kappaB inhibitor PDTC. prolinedithiocarbamate 155-159 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 34098041-0 2021 Bone Mesenchymal Stem Cells Attenuate Resiniferatoxin-induced Neuralgia via Inhibiting TRPA1-PKCdelta-P38/MAPK-p-P65 pathway in Mice. resiniferatoxin 38-53 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 113-116 34422538-7 2021 We also observed that CC34 exerted anti-inflammatory activity by suppressing the phosphorylation of IKKbeta, IkappaBalpha, and NF-kappaB p65 in vitro. cc34 22-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 137-140 34098041-8 2021 Our research suggested that activation of PKCdelta-CaMKIIalpha-P38/MAPK-p-P65 pathway and mushroom dendritic spines abnormal increase in the spinal cord is the main mechanism of RTX induced neuropathic pain, and transplant of BMSCs to the damaged nerve may offer promising approach for neuropathic pain. resiniferatoxin 178-181 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-77 34465889-0 2022 Ubiquitination of NF-kappaB p65 by FBXW2 suppresses breast cancer stemness, tumorigenesis, and paclitaxel resistance. Paclitaxel 95-105 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 28-31 34183378-4 2021 Moreover, silybin suppressed liver inflammation in HFD-fed mice and inhibited NF-kappaB translocation into the nucleus through elevation of SIRT2 expression and promotion of p65 deacetylation. Silybin 10-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 174-177 34183378-10 2021 In summary, silybin increased NAD+ concentration, promoted SIRT2 expression and lowered p65 acetylation both in vivo and in vitro, which supported the recovery of CYP3A expression. Silybin 12-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 34273909-7 2021 Tumor-associated proteins, including p65 and Ki-67, were downregulated by the IRAK1/4 inhibitor in AOM/DSS-treated mice. Azoxymethane 99-102 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 37-40 34273909-7 2021 Tumor-associated proteins, including p65 and Ki-67, were downregulated by the IRAK1/4 inhibitor in AOM/DSS-treated mice. dss 103-106 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 37-40 34581093-7 2021 The results of network pharmacology showed that 15 potential active components such as EC, procyanidin B1, and luteolin presumedly functioned in the treatment of ALI through nuclear transcription factor-kappaB(NF-kappaB) signaling pathway, transforming growth factor-beta(TGF-beta) signaling pathway, and adenosine 5"-monophosphate(AMP)-activated protein kinase(AMPK) signaling pathway through key targets, such as RELA(P65). procyanidin B1 91-105 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 415-423 34581093-7 2021 The results of network pharmacology showed that 15 potential active components such as EC, procyanidin B1, and luteolin presumedly functioned in the treatment of ALI through nuclear transcription factor-kappaB(NF-kappaB) signaling pathway, transforming growth factor-beta(TGF-beta) signaling pathway, and adenosine 5"-monophosphate(AMP)-activated protein kinase(AMPK) signaling pathway through key targets, such as RELA(P65). Luteolin 111-119 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 415-423 34581093-7 2021 The results of network pharmacology showed that 15 potential active components such as EC, procyanidin B1, and luteolin presumedly functioned in the treatment of ALI through nuclear transcription factor-kappaB(NF-kappaB) signaling pathway, transforming growth factor-beta(TGF-beta) signaling pathway, and adenosine 5"-monophosphate(AMP)-activated protein kinase(AMPK) signaling pathway through key targets, such as RELA(P65). Adenosine 305-314 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 415-423 34581093-7 2021 The results of network pharmacology showed that 15 potential active components such as EC, procyanidin B1, and luteolin presumedly functioned in the treatment of ALI through nuclear transcription factor-kappaB(NF-kappaB) signaling pathway, transforming growth factor-beta(TGF-beta) signaling pathway, and adenosine 5"-monophosphate(AMP)-activated protein kinase(AMPK) signaling pathway through key targets, such as RELA(P65). Adenosine Monophosphate 332-335 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 415-423 34581093-8 2021 The results of in vitro experiments showed that 25 mumol L~(-1) EC had no toxicity to cells and could inhibit the expression of the p65-phosphorylated protein in the NF-kappaB signaling pathway to down-regulate the expression of downstream inflammatory cytokines, including tumor necrosis factor-alpha(TNF-alpha), IL-1beta and nitric oxide(NO), and up-regulate the expression of IL-10. Nitric Oxide 327-339 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 132-135 34294378-5 2021 Andrographolide inhibited PCP-induced production of inflammatory cytokines, decreased p-p65, p-IkappaBalpha, p-p38 and p-ERK1/2 in the prefrontal cortex. andrographolide 0-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 34247115-9 2021 Further, RT-PCR showed that the ectopic transcription of inflammation-associated genes including TNFalpha, IL-1beta, IL-6, COX-2, iNOS, and p65 was reversed in 5XFAD mice treated with tetrandrine. tetrandrine 184-195 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 140-143 34247115-11 2021 Tetrandrine pre-treatment also inhibited the expression of TLR4, p65, iNOS, and COX-2 in BV2 cells induced by Abeta 1-42. tetrandrine 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 65-68 34465889-8 2022 FBXW2 overexpression abrogates the effects of p65 on paclitaxel resistance in vitro and in vivo. Paclitaxel 53-63 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 46-49 34421084-8 2021 Moreover, Dex participates in the regulation of HMGB1, Toll-like receptor 4 (TLR4), NFkappab (p-65) expression and the phosphorylation of IkappaB-alpha. Dexmedetomidine 10-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 94-98 34466017-8 2021 The expression of ATGs including LC3, Beclin-1, and ATG5, and NF-kappaB p65 in lung tissue in the vitamin D-deficient OVA-mediated group was increased compared with vitamin D-supplemented OVA-mediated group. Vitamin D 98-107 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 34466017-8 2021 The expression of ATGs including LC3, Beclin-1, and ATG5, and NF-kappaB p65 in lung tissue in the vitamin D-deficient OVA-mediated group was increased compared with vitamin D-supplemented OVA-mediated group. Vitamin D 165-174 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 34380537-8 2021 Hepatocyte-specific p65-deficient mice markedly decreased in the HCC incidence and size of tumours by the repressing of the proliferation of malignant cells in a DEN-induced HCC model. Diethylnitrosamine 162-165 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 20-23 34118251-7 2021 Furthermore, DEX therapy downregulated the expression of p-p65 in macrophages and VSMCs, which suggested that DEX might ameliorate BAPN-induced TAAD by suppressing NF-kappaB signaling. Dexamethasone 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-62 34118251-7 2021 Furthermore, DEX therapy downregulated the expression of p-p65 in macrophages and VSMCs, which suggested that DEX might ameliorate BAPN-induced TAAD by suppressing NF-kappaB signaling. Dexamethasone 110-113 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-62 34118251-7 2021 Furthermore, DEX therapy downregulated the expression of p-p65 in macrophages and VSMCs, which suggested that DEX might ameliorate BAPN-induced TAAD by suppressing NF-kappaB signaling. Aminopropionitrile 131-135 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-62 34348746-12 2021 LPS-induced NF-kappaB/p65 nuclear translocation was inhibited by both 3,3",4,5"-TMS and 3,4",5-TMS. 3,3',4,5'-tetramethoxystilbene 70-83 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 22-25 34118309-9 2021 Concomitantly, overexpressing miR-216a-5p also restrained the inflammatory response and microglia activation in CFA-induced inflammatory mouse models, concomitant with the decreases in the expression of HMGB1, TLR4 and p-p65 NF-kB in spinal cord. mir-216a-5p 30-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 221-224 34348746-12 2021 LPS-induced NF-kappaB/p65 nuclear translocation was inhibited by both 3,3",4,5"-TMS and 3,4",5-TMS. 3,4',5-trimethoxystilbene 88-98 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 22-25 34274951-9 2021 Thus, our data illustrate a novel mechanism by which DJ-1 facilitates the interaction between IkappaBalpha and p65 by binding to p65 in microglia, and thus repressing microglial activation and exhibiting the protection of DA neurons from neuroinflammation-mediated injury in PD. Dopamine 222-224 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 111-114 34116734-6 2021 RESULTS: Dencichine suppressed osteoclastogenesis through the inhibition of phosphorylation of p65, p50 (NF-kappaB pathway), p38, ERK and JNK (MAPKs pathway) in vitro. oxalyldiaminopropionic acid 9-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-98 34293804-6 2021 Further evaluation demonstrated that compared with suffrutines A, suffrutines B could more significantly inhibit the phosphorylation of IKKalpha/beta, the degradation of IkappaBalpha, and the nuclear translocation of the p65 and p52 subunits in the canonical and non-canonical nuclear factor-kappaB pathways. suffrutines b 66-79 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 221-224 34284715-11 2021 Moreover, DSS significantly inhibited IL-1beta-induced phosphorylation of p-IkappaBalpha and p-p65 in a dose-dependent manner in chondrocytes, suggesting it plays a role in the NF-kappaB signaling pathway. 3,4-dihydroxyphenyllactic acid 10-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-98 34238104-8 2021 Moreover, the results of IHC showed that the miR-494 antagomir downregulated p65 NF-kappaB in kidney tissues from the LPS-induced AKI mice, accompanied by decreased levels of TNF-alpha, IL-1beta, IL-6, MDA, NO, and ROS but increased levels of SOD and GSH. ros 215-218 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-90 34244427-7 2021 Mechanistically, HIPK2 bound and phosphorylated histone deacetylase 3 (HDAC3) at serine 374 to inhibit its enzymatic activity, thus reducing the deacetylation of p65 at lysine 218 to suppress NF-kappaB activation. Serine 81-87 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 162-165 34244427-7 2021 Mechanistically, HIPK2 bound and phosphorylated histone deacetylase 3 (HDAC3) at serine 374 to inhibit its enzymatic activity, thus reducing the deacetylation of p65 at lysine 218 to suppress NF-kappaB activation. Lysine 169-175 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 162-165 34237707-4 2021 Mechanistically, molecular docking tests revealed that alpha-Cyperone stably and effectively binds to p65, p38, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK). alpha-cyperone 55-69 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-105 34356340-8 2021 The protective effects of NAC were, at least, partly due to a decrease in the production of tumor necrosis factor-alpha (TNF-alpha) by acinar cells, which was concomitant with the inhibition of NF-kappaB(p65) nuclear translocation. Acetylcysteine 26-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 194-208 34107997-8 2021 In addition, 2-DG significantly inhibited LPS-induced acetylation of p65/RelA on lysine 310, which is mediated by NAD-dependent protein deacetylase sirtuin-1 (SIRT1) and is critical for NF-kappaB activation. Deoxyglucose 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-72 34209652-7 2021 Moreover, DON exposure downregulated reproductive hormone gene expression and significantly increased nuclear factor kappa B (p65) activation and mitogen-activated protein kinase phosphorylation. deoxynivalenol 10-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 126-129 34202301-7 2021 In addition, alantolactone was found to inhibit STAT3 phosphorylation and NF-kappaB p65 nuclear translocation in HaCaT keratinocytes. alantolactone 13-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 34222477-8 2021 THC administration decreased TNF-alpha, Nox2, Nox4, and phosphorylated p65 levels and activated the Nrf2 pathway. tetrahydrocurcumin 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 71-74 34356841-9 2021 Accordingly, (S)-(+)-carvone did not affect LPS-induced phosphorylation of NF-kappaB/p65 on Ser536 and its nuclear translocation, but it significantly decreased LPS-induced IkappaB-alpha resynthesis, a NF-kappaB-dependent process, and NF-kappaB/p65 acetylation on lysine (Lys) 310. carvone 21-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 245-248 34356841-9 2021 Accordingly, (S)-(+)-carvone did not affect LPS-induced phosphorylation of NF-kappaB/p65 on Ser536 and its nuclear translocation, but it significantly decreased LPS-induced IkappaB-alpha resynthesis, a NF-kappaB-dependent process, and NF-kappaB/p65 acetylation on lysine (Lys) 310. Lysine 264-270 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 245-248 34356841-9 2021 Accordingly, (S)-(+)-carvone did not affect LPS-induced phosphorylation of NF-kappaB/p65 on Ser536 and its nuclear translocation, but it significantly decreased LPS-induced IkappaB-alpha resynthesis, a NF-kappaB-dependent process, and NF-kappaB/p65 acetylation on lysine (Lys) 310. Lysine 272-275 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 245-248 34107997-8 2021 In addition, 2-DG significantly inhibited LPS-induced acetylation of p65/RelA on lysine 310, which is mediated by NAD-dependent protein deacetylase sirtuin-1 (SIRT1) and is critical for NF-kappaB activation. Deoxyglucose 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-77 34107997-8 2021 In addition, 2-DG significantly inhibited LPS-induced acetylation of p65/RelA on lysine 310, which is mediated by NAD-dependent protein deacetylase sirtuin-1 (SIRT1) and is critical for NF-kappaB activation. Lysine 81-87 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-72 34107997-8 2021 In addition, 2-DG significantly inhibited LPS-induced acetylation of p65/RelA on lysine 310, which is mediated by NAD-dependent protein deacetylase sirtuin-1 (SIRT1) and is critical for NF-kappaB activation. Lysine 81-87 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-77 34085926-5 2021 Mechanistically, Rela deletion suppresses expression of Aldh1a1, an enzyme required for retinoic acid synthesis from vitamin A. Tretinoin 88-101 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 17-21 34085926-5 2021 Mechanistically, Rela deletion suppresses expression of Aldh1a1, an enzyme required for retinoic acid synthesis from vitamin A. Vitamin A 117-126 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 17-21 34069822-9 2021 In addition, SA reduced renal p65 and urinary prostaglandin E2, prostaglandin F1alpha, and interleukin-6 in both WT and TRPV1-/- mice (all p < 0.05). Salicylates 13-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 30-33 34243622-16 2021 TP dose-dependently inhibited the activation of NF-kappaB pathway induced by LPS, indicated by the changes of phosphorylations of p65 (p-p65), p-IKKalpha/beta and p-IkappaBalpha, and weakened p65-DNA binding activity. triptolide 0-2 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 130-133 34243622-16 2021 TP dose-dependently inhibited the activation of NF-kappaB pathway induced by LPS, indicated by the changes of phosphorylations of p65 (p-p65), p-IKKalpha/beta and p-IkappaBalpha, and weakened p65-DNA binding activity. triptolide 0-2 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 137-140 34243622-16 2021 TP dose-dependently inhibited the activation of NF-kappaB pathway induced by LPS, indicated by the changes of phosphorylations of p65 (p-p65), p-IKKalpha/beta and p-IkappaBalpha, and weakened p65-DNA binding activity. triptolide 0-2 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 192-195 34277801-0 2021 Apatinib enhances the anti-tumor effect of paclitaxel via the PI3K/p65/Bcl-xl pathway in triple-negative breast cancer. apatinib 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 67-70 34277801-0 2021 Apatinib enhances the anti-tumor effect of paclitaxel via the PI3K/p65/Bcl-xl pathway in triple-negative breast cancer. Paclitaxel 43-53 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 67-70 34277801-2 2021 This study aimed to investigate the synergistic effects of apatinib and paclitaxel (PTX) on triple-negative breast cancer (TNBC) in vivo and in vitro, and to explore the molecular mechanism of the PI3K/p65/Bcl-xl pathway. apatinib 59-67 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 202-205 34277801-2 2021 This study aimed to investigate the synergistic effects of apatinib and paclitaxel (PTX) on triple-negative breast cancer (TNBC) in vivo and in vitro, and to explore the molecular mechanism of the PI3K/p65/Bcl-xl pathway. Paclitaxel 72-82 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 202-205 34277801-2 2021 This study aimed to investigate the synergistic effects of apatinib and paclitaxel (PTX) on triple-negative breast cancer (TNBC) in vivo and in vitro, and to explore the molecular mechanism of the PI3K/p65/Bcl-xl pathway. Paclitaxel 84-87 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 202-205 34277801-4 2021 Western blot (WB) was conducted to detect protein expression levels of PI3K, p65, and Bcl-xl after the application of apatinib and PTX. apatinib 118-126 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-80 34277801-4 2021 Western blot (WB) was conducted to detect protein expression levels of PI3K, p65, and Bcl-xl after the application of apatinib and PTX. Paclitaxel 131-134 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-80 34277801-8 2021 Apatinib could reduce the expression of p-PI3K, p65, and Bcl-xl proteins (P<0.05). apatinib 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 48-51 34277801-10 2021 Conclusions: Apatinib could enhance the anti-tumor effect of PTX on TNBC cells through the PI3K/p65/Bcl-xl molecular pathway, and apatinib combined with PTX might be a promising option for TNBC treatment. apatinib 13-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-99 34277801-10 2021 Conclusions: Apatinib could enhance the anti-tumor effect of PTX on TNBC cells through the PI3K/p65/Bcl-xl molecular pathway, and apatinib combined with PTX might be a promising option for TNBC treatment. Paclitaxel 61-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-99 33713122-7 2021 Melatonin inhibited the transcriptional activity of NF-kappaB by interfering with the binding of PRMT1 and NF-kappaB subunit p65 in RANKL-treated BMDMs. Melatonin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 125-128 34095107-10 2021 Interestingly, PREP disruption inhibited p-ERK and p-p65 and reduced the levels of proinflammatory cytokines in response to endotoxin and proline-glycine-proline, which guided macrophage/neutrophil infiltration in mice fed a HFD for 24 weeks. Glycine 146-153 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 34095107-10 2021 Interestingly, PREP disruption inhibited p-ERK and p-p65 and reduced the levels of proinflammatory cytokines in response to endotoxin and proline-glycine-proline, which guided macrophage/neutrophil infiltration in mice fed a HFD for 24 weeks. Proline 154-161 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 34231485-12 2021 p-p65/ p65 ratio in the DSS + ICA group was remarkably enhanced compared to the DSS group (P < .05). icariin 30-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 2-5 34231485-12 2021 p-p65/ p65 ratio in the DSS + ICA group was remarkably enhanced compared to the DSS group (P < .05). dss 24-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 2-5 34231485-12 2021 p-p65/ p65 ratio in the DSS + ICA group was remarkably enhanced compared to the DSS group (P < .05). icariin 30-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 7-10 34231485-12 2021 p-p65/ p65 ratio in the DSS + ICA group was remarkably enhanced compared to the DSS group (P < .05). dss 24-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 7-10 34231485-12 2021 p-p65/ p65 ratio in the DSS + ICA group was remarkably enhanced compared to the DSS group (P < .05). dss 80-83 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 2-5 34231485-12 2021 p-p65/ p65 ratio in the DSS + ICA group was remarkably enhanced compared to the DSS group (P < .05). dss 80-83 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 7-10 35593299-7 2022 Furthermore, western blot and immunofluorescent staining results revealed that carnosol markedly suppressed the phosphorylation of p65 induced by RANKL and blocked its nuclear translocation, indicating the suppression of NF-kappaB signaling pathway. carnosol 79-87 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 131-134 34384259-11 2021 The phosphorylation levels of p38, JNK, ERK1/2, P65 and cAMP response element-binding protein (CREB) in the mouse were significantly reduced in AM1241 pretreatment, while the level of p-JNK increased. AM 1241 144-150 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 48-51 34384259-12 2021 In addition, the P/T-P65 and P/T-CREB of the AM1241 pretreatment group were significantly reduced. AM 1241 45-51 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 21-24 35567986-10 2022 Mechanistically, PA treatment suppressed the nuclear factor-kappaB (NF-kappaB) p65 nuclear translocation and nucleotide-binding domain like receptor protein 3 (NLRP3) inflammasome activation. Proanthocyanidins 17-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 79-82 35344629-5 2022 Dexamethasone reduced TAAD formation and inhibited MAPK (p-p38) and NF-kappaB (p-p65) signaling pathways. Dexamethasone 0-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 81-84 35635075-8 2022 As expected, cotreatment of macrophages with Hyd and AscA synergistically inhibited the activation of p38 MAPK and p-p65, and the effect could be reversed by additional stimulation with 3-NP. 3-nitropropionic acid 186-190 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-120 35488871-12 2022 We determined that cisplatin treatment activated NF-kappaB subunit P65, and inhibition of P65 increased the mRNA levels of BRAP in HK2cells. Cisplatin 19-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-93 35628627-7 2022 The Western blot assay results show that xanthotoxol suppresses LPS-induced p65 translocation from cytosol to the nucleus in RAW 264.7 cells. xanthotoxol 41-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 76-79 35178902-12 2022 Also, this plant impaired DSS-provoked phosphorylation levels of extracellular signal-regulated kinases (ERK), c-Jun N-terminal kinases (JNK), p38 mitogen-activated protein kinases (p38), p65, and IkappaB. dss 26-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 188-191 35618286-9 2022 Mechanistically, bufalin inhibits overexpression of p50 nuclear factor kappa B (NF-kappaB) factor, leading to the predominance of p65-p50 heterodimers over p50 homodimers in the nuclei. bufalin 17-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 130-133 35598398-9 2022 Next, we identified the downstream signaling pathway of CD147, and proved that the anti-RA effects of GEN were mediated by down-regulating the expression of p38, IkappaBalpha and p65 in vivo and in vitro assays. Radium 88-90 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 179-182 35598398-9 2022 Next, we identified the downstream signaling pathway of CD147, and proved that the anti-RA effects of GEN were mediated by down-regulating the expression of p38, IkappaBalpha and p65 in vivo and in vitro assays. gentiopicroside 102-105 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 179-182 35571728-7 2022 Molecular docking results revealed that beta-carotene and sitosterol were acting as interference factors in attenuating inflammation by binding to an accessory protein of ERK, JNK, AKT, and NF-kappaB p65. beta Carotene 40-53 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 200-203 35571728-7 2022 Molecular docking results revealed that beta-carotene and sitosterol were acting as interference factors in attenuating inflammation by binding to an accessory protein of ERK, JNK, AKT, and NF-kappaB p65. gamma-sitosterol 58-68 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 200-203 35488871-13 2022 ChIP assay and Dual-luciferase reporter gene assay verified P65 binding to the C6ORF89 promoter and reduced its mRNA expression upon cisplatin treatment. Cisplatin 133-142 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 60-63 35528515-7 2022 Mechanistically, the expressions of p-AKT, p-mTOR, p-P65, NLRP3, and cleaved-caspase-1 were decreased after MgH2 treatment, indicating that AKT/mTOR and NF-kappaB/NLRP3/IL-1beta pathways participated in the protective effects of MgH2. magnesium;hydride 108-112 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 35502210-13 2022 Conclusion: We demonstrated that EDA treatment had a protective role in PM-induced lung inflammation through maintaining mitochondrial balance and regulating the ROS-NF-kappaB p65 signaling pathway. Edaravone 33-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 176-179 35502210-13 2022 Conclusion: We demonstrated that EDA treatment had a protective role in PM-induced lung inflammation through maintaining mitochondrial balance and regulating the ROS-NF-kappaB p65 signaling pathway. Reactive Oxygen Species 162-165 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 176-179 35458235-0 2022 Friedelin Alleviates the Pathogenesis of Collagenase-Induced Tendinopathy in Mice by Promoting the Selective Autophagic Degradation of p65. friedelin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 135-138 35517504-9 2022 Mechanistic analysis revealed that acacetin not only inhibits the expression of the major transcription factor NFATc1 and NF-kappaB during RANKL-induced osteoclast formation, but also suppresses RANKL-induced the phosphorylation of Akt, GSK3beta, IkappaBalpha, and p65. acacetin 35-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 265-268 35063480-5 2022 CDs (except GlcNL) significantly upregulated IkappaB-alpha level, and downregulated p65 and p38 phosphory lation and TLR-4 mRNA transcription level, indicating inhibition of TRL-4/NF-kappaB/MAPK signaling pathway activity. cds 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 35396645-9 2022 In contrast, sirtinol, an inhibitor of SIRT1, increases p65 acetylation, activates the NF-kappaB pathway, induces vascular smooth muscle cell transdifferentiation and senescence, and promotes vascular calcification. sirtinol 13-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 56-59 35063480-5 2022 CDs (except GlcNL) significantly upregulated IkappaB-alpha level, and downregulated p65 and p38 phosphory lation and TLR-4 mRNA transcription level, indicating inhibition of TRL-4/NF-kappaB/MAPK signaling pathway activity. glcnl 12-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 35331238-6 2022 The experiments showed that ZnO/Ag nanoparticles could exhibit a self-therapeutic effect that was attributed to reducing innate cytokine profiles by inactivating p65 in proinflammatory macrophages and abrogating secretion of adaptive cytokines in KCs by downregulating ROS-mediated STAT3-cyclin D1 signaling. Zinc Oxide 28-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 162-165 35546047-7 2022 Cyn treatment reduced hind paw swelling and M1 macrophage infiltration, suppressed the mRNA expression of inflammatory factors, and inhibited NLRP3 inflammasome activation in vivo, in addition to inhibiting the phosphorylation of IKKa/beta, p65, and c-Jun NH 2-terminal kinase (JNK). cynarine 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 241-244 35306537-4 2022 Levels of phosphorylated IkBalpha and p65 significantly rose in mdx/mTR-/- dystrophic hearts and Wt1 expression declined in the epicardium of mdx/mTR-/- mice when nuclear factor kappaB (NF-kappaB) and inflammation were inhibited by metformin. Metformin 232-241 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 38-41 35214151-2 2022 Here, we assess the impact of silica-coated calcium phosphate nanoparticles carrying encapsulated siRNA against NF-kappaB p65 on a murine model of colitis. Silicon Dioxide 30-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-125 35126696-13 2022 Subsequently, western blot analysis indicated that lidocaine suppressed phosphorylated (p)-p38 and p-p65 expression levels in AR mice. Lidocaine 51-60 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 35066371-11 2022 Finally, Andrograpanin inhibited the IkappaBalpha degradation and p65 phosphorylation in LPS-stimulated bEECs and LPS-induced endometrial injury. andrograpanin 9-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 35340409-9 2022 Results: ETC-1002 inhibited the production of proinflammatory cytokines, promoted AMPK phosphorylation, and decreased IkappaBalpha and NF-kappaB p65 phosphorylation levels in Pg-LPS-treated RAW264.7 macrophages. 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid 9-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 145-148 35370629-9 2022 KCF18 could effectively decrease the p65 nucleus translocation induced by cytokines, and a mice endotoxemia experiment demonstrated that KCF18 could reduce the expression of IL-6 and the increase of white blood cells in the blood stimulated by lipopolysaccharides. kcf18 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 37-40 35370629-9 2022 KCF18 could effectively decrease the p65 nucleus translocation induced by cytokines, and a mice endotoxemia experiment demonstrated that KCF18 could reduce the expression of IL-6 and the increase of white blood cells in the blood stimulated by lipopolysaccharides. kcf18 137-142 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 37-40 35126813-11 2022 The mRNA and protein levels of IL-1beta, TNF-alpha, and NF-kappaB/p65 in colonic tissue from the colitis mice were decreased after the STV-Na treatment. stv-na 135-141 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 35112986-10 2022 In addition, alpha-TOH reduces p65 phosphorylation and nuclear translocation in alveolar epithelial cells in vivo and in vitro, thus, inhibiting the activity of the nuclear factor kappa-B (NF-kappaB) signaling pathway. alpha-Tocopherol 13-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-34 35165276-5 2022 Under the same conditions, METTL3 knockdown inhibited, whereas METTL3 overexpression promoted p65 phosphorylation in MODE-K cells; NF-kappaB inhibitor JSH-23 partially abolished the promotive effects of METTL3 overexpression upon p65 phosphorylation. 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine 151-157 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 94-97 35165276-5 2022 Under the same conditions, METTL3 knockdown inhibited, whereas METTL3 overexpression promoted p65 phosphorylation in MODE-K cells; NF-kappaB inhibitor JSH-23 partially abolished the promotive effects of METTL3 overexpression upon p65 phosphorylation. 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine 151-157 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 230-233 35185599-8 2021 In addition, NF-kB p65 translocation was also suppressed by myricanol. myricanol 60-69 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 19-22 35087169-4 2022 Interestingly, the transcription factors promoting ciliogenesis (ciliary TFs) (e.g., multicilin) and ZFTA-RELA upregulated luciferase activity using a 5" upstream sequence of ZFTA in cultured cells. zfta 175-179 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-110 35060345-8 2022 4-IPP hindered the binding between MIF and CD74 as well as p65. 4-iodo-6-phenylpyrimidine 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-62 35200626-6 2022 COS also activated SIRT1 to reduce the acetylation of p65 protein at lysine 310, which was reversed by silencing SIRT1 by siRNA. Lysine 69-75 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 54-57 35162978-4 2022 In this study, we demonstrated that the combination of valproate and resveratrol can restore the normal acetylation state of RelA in the SOD1(G93A) murine model of ALS, in order to obtain the neuroprotective form of NF-kB. Valproic Acid 55-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 125-129 35162978-4 2022 In this study, we demonstrated that the combination of valproate and resveratrol can restore the normal acetylation state of RelA in the SOD1(G93A) murine model of ALS, in order to obtain the neuroprotective form of NF-kB. Resveratrol 69-80 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 125-129 34636875-10 2022 Compared with the AP group, both ISO treatments reduced brain phospho-Tau, phosphor-p65, phosphor-inhibitor of NF-kappaB, and brain and serum LPS and TNF-alpha by 17.9%-72.5% and increased brain and serum IL-4 and IL-10 by 130%-210% in the AP + ISO-L and AP + ISO-H groups (P < 0.05). homoorientin 33-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 34976218-9 2022 5Aza induced cholesterol accumulation, p65 phosphorylation and IL-6 expression in an ABC A9-dependent manner. Decitabine 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 39-42 33781833-9 2021 Furthermore, mechanism studies showed that TAK1 and its downstream pathway p38/JNK/ERK1/2/p65 were inhibited by minocycline, which led to lower IL-1beta and TNFalpha expression, but increased IL-10 expression. Minocycline 112-123 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-93 34976218-7 2022 Mechanistically, 5Aza stimulated primary mouse macrophages toward to a M1-like phenotype characterized by the increase of p65 phosphorylation and IL-6 expression. Decitabine 17-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-125 3418715-2 1988 The crystals grown from solutions of 2-methyl-2,4-pentanediol diffract to high resolution and belong to the hexagonal space group P6(1) (P6(5)) with unit cells dimensions a = b = 64.44 A, c = 53.91 A, y = 120 degrees and V = 1.94 x 10(5) A3 (1 A = 0.1 nm). hexylene glycol 37-61 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 137-142 33756153-5 2021 Previously, peptide analogs of the p65 binding domain of GILZ, referred to as GA have been shown to suppress pathology in the lipopolysaccharide induced model of neuroinflammation. Gallium 78-80 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 35-38 33991638-19 2021 Furthermore, Al-EE inhibited the nuclear protein levels of NF-kappaB (p65) and NF-kappaB-driven luciferase reporter gene activity in RAW264.7 macrophage cells. al-ee 13-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 34055059-11 2021 Rosiglitazone significantly inhibited LPS-induced upregulation of p65 phosphorylation levels and downregulated IkappaBalpha expression levels. Rosiglitazone 0-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 33675461-8 2021 Immunofluorescence analysis showed that militarine suppressed NF-kappaB activity through inhibiting p65 nuclear translocation. militarine 40-50 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 100-103 33990219-11 2021 Moreover, fargesin exerted protective effects by suppressing p38/ERK MAPK and p65/NF-kappaB signaling. fargesin 10-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 78-81 33559894-8 2021 Preceding TNFalpha expression, we detected Phosphoserine 536 and acetylated lysine 310 of RelA after 2 hours exposure with P. gingivalis. Lysine 76-82 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-94 33559894-10 2021 Blocking TLR2/4 signaling prevented Sirt1 cleavage, loss of deacetylase activity, and TNFalpha secretion, while co-administering CA074Me (a cathepsin B inhibitor) with P. gingivalis reduced RelA promoter enrichment, resulting in impaired TNFalpha expression. CA 074 methyl ester 129-136 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 190-194 34051263-10 2021 Taken together, these findings suggested that high glucose induced RANK in podocytes and caused the increase of NADPH oxidase 4 and P22phox via p65, possibly together with the cytokines TNF- alpha, MAC-2 and IL-1 beta, resulting in podocyte injury. Glucose 51-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 144-147 33982891-12 2021 Immunostaining of cartilage revealed that Postn knockdown reduced the DMM-induced MMP-13 intensity, phosphorylation of p65, and immunoreactivity of aggrecan neoepitope, DIPEN. dimethylmyleran 70-73 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-122 33484966-8 2021 Altogether, our findings unraveled that METTL3 played a pivotal tumor-suppressor role in PTC carcinogenesis through c-Rel and RelA-participated inactivation of NF-kappaB pathway via cooperating with YTHDF2, and altered the TANs infiltration to regulate tumor growth, which extends our understanding of the relationship between m6A modification and plasticity of the tumor microenvironment. tans 223-227 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 126-130 33460751-14 2021 As a consequence of preserved mitochondrial homeostasis, Suhuang inhibited NF-kappaB pathway activation by prevention of NF-kappaB-p65 phosphorylation and IkappaBalpha degradation. suhuang 57-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 131-134 33974900-9 2021 Furthermore, ASP suppressed oxidative stress through increasing Nrf2, HO-1 and NQO-1 proteins expressions, and down-regulated nuclear levels of p65 to inhibit DSS-induced colonic oxidative stress and inflammation. asperuloside 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 144-147 33974900-9 2021 Furthermore, ASP suppressed oxidative stress through increasing Nrf2, HO-1 and NQO-1 proteins expressions, and down-regulated nuclear levels of p65 to inhibit DSS-induced colonic oxidative stress and inflammation. Dextran Sulfate 159-162 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 144-147 33974900-10 2021 Validation of the molecular docking results also indicated that ASP interacts with Nrf2 or p65 proteins. asperuloside 64-67 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-94 34054527-10 2021 Mechanistically, LIQ enhanced the phosphorylation of AMP-activated protein kinase alpha2 (AMPKalpha2) and decreased the phosphorylation of mTORC1, IkappaBalpha and NFkappaB/p65. liquiritin 17-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 173-176 33962939-4 2021 Thus, c-Cbl deficiency in DCs promotes alpha-mannan-induced activation of RelB, which suppresses p65-mediated transcription of an anti-inflammatory cytokine gene, il10, thereby aggravating DSS-induced colitis. alpha-mannan 39-51 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 97-100 33749522-12 2021 Rifampicin downregulated TLR4 and MyD88 protein levels and inhibited NF-kappaB inhibitor alpha and NF-kappaB inhibitor kinase beta phosphorylation, thus reducing p65 nuclear transfer by inhibiting NF-kappaB signaling activation in LPS-treated mice. Rifampin 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 162-165 33852061-9 2021 The expression of NF-kappaB (p65) and ST2 was upregulated by OVA and suppressed by H2. Deuterium 83-85 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 29-32 33844304-7 2021 Farrerol also downregulated the p-p65, p-IkappaBalpha expression and upregulated the PPAR-gamma expression in RAW 264.7 cells. farrerol 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 34-37 33961837-7 2021 The accumulated bilirubin leads to hyperphosphorylation of IkappaB-alpha, Ikk-beta, and p65 and a significant increase of inflammatory factor. Bilirubin 16-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 33961837-14 2021 Finally, Schisandrin B, an active ingredient with hepatoprotective effects, extracted from a traditional Chinese medicinal herb, which could protect the liver from bilirubin metabolism disorders caused by ugt1a1 deficiency by downregulating p65 phosphorylation, inhibiting Kupffer cells, reducing inflammation levels. schizandrin B 9-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 241-244 33945918-7 2021 The in vitro experiment of aloperine proved that aloperine can inhibit the degradation of IkappaBalpha and the phosphorylation of P65, ERK and JNK. aloperine 27-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 130-133 33945918-7 2021 The in vitro experiment of aloperine proved that aloperine can inhibit the degradation of IkappaBalpha and the phosphorylation of P65, ERK and JNK. aloperine 49-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 130-133 33607154-4 2021 The computational data from network pharmacology identified the crucial genes of formononetin against liver injury, listed as TNF-alpha, NFkappaB-p65, TLR3, RELA, TRAF6, IKBKG, IKBKB, TNFRSF1A. formononetin 81-93 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 157-161 33638773-7 2021 In miR-506-3p mimic group or siRNA-CCL2 group, the expression of CCL2, TLR4, NF-kappaB (p65) and Bcl-2 decreased obviously, while that of Bax increased, cell proliferation decreased, G1 phase prolonged, G2 & S phases shortened, and apoptosis rate increased significantly (all P < 0.05), whereas the opposite trends were found in miR-506-3p inhibitor group (all P < 0.05). mir-506-3p 3-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 33932312-7 2021 In addition, gamma-oryzanol inhibited TGF-beta-Smad-NADPH oxidase 4 pathway and inflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6, and p65 NF-kappaB subunit, which cause skeletal muscle weakness. gamma-oryzanol 13-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 146-159 33930529-6 2021 TCE exposure led to reduction in Nrf2 expression, but increased phos-NF-kappaB (p65) and iNOS along with increased phosphorylation of MAPKs (p38, ERK and JNK) and downstream pro-inflammatory cytokines IL-12, TNF-alpha and RANTES in the livers in a time-dependent manner. Trichloroethylene 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 80-83 33870507-8 2021 Meanwhile, our molecular docking studies indicated nepetin had a powerful binding capacity to p65. eupafolin 51-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 94-97 33593544-4 2021 Western blot of joint tissues showed that cDHPS significantly inhibited the phosphorylation of IkappaB, p65, JNK, p38, ERK1/2, AKT, PI3K, JAK1 and STAT3 in CIA mice. gimeracil 42-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 104-107 33958974-10 2021 Treatment with the anti-IL-16 nAb also reduced p65 pathway activation, decreased M1 macrophage-related marker and cytokine expression, and protected against cardiomyocyte apoptosis in DOX-induced mice. nab 30-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 47-50 33844454-14 2021 Se@SiO2 nanocomposites ultimately inhibited TLR4/ Myd88/p-p65 pathway and increased the level of NQO1, Nrf2, and HO-1 protein. Selenium 0-2 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 58-61 33844454-14 2021 Se@SiO2 nanocomposites ultimately inhibited TLR4/ Myd88/p-p65 pathway and increased the level of NQO1, Nrf2, and HO-1 protein. Silicon Dioxide 3-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 58-61 33792148-4 2021 However, ROCK inhibitor Y-27632 could attenuate phosphorylation levels of p65 and IkappaBalpha and restore histopathological changes of the lung tissue. Y 27632 24-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-77 33725040-8 2021 Furthermore, Zingerone treatment could decrease the expression of phosphorylated (p)-IkappaBalpha and p65 (nuclear) and increase the expression of phosphorylation of AMP-activated protein kinase (p-AMPK), nuclear factor erythroid-2-related factor 2 (Nrf2), and hemeoxygenase-1 (HO-1) to alleviate oxidative damage and inflammation both in vivo and in vitro. zingerone 13-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-105 33537817-7 2021 The in vitro experiments indicated that LPS-mediated inflammation was attenuated due to the protective properties of BAT and of taurine, probably through the inhibition of phosphorylated p65 NF-kappaB subunit (Ser 536) nuclear translocation. Taurine 128-135 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 187-200 33537817-7 2021 The in vitro experiments indicated that LPS-mediated inflammation was attenuated due to the protective properties of BAT and of taurine, probably through the inhibition of phosphorylated p65 NF-kappaB subunit (Ser 536) nuclear translocation. Serine 210-213 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 187-200 33921372-6 2021 Furthermore, TCDD increased the expression of aryl hydrocarbon receptor (AHR), CYP1A1, proinflammatory cytokines, oxidative stress markers (NADPH oxidase (Nox) 2, Nox4), and phosphorylated P65NF-kB, whereas the expression of autophagy-related factors and the antioxidant marker nuclear factor-erythroid 2-related factor 2 (NRF2) decreased. Polychlorinated Dibenzodioxins 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 189-197 33981577-15 2021 The effect of tyloxapol pretreatment on p65 nuclear translocation was evaluated utilizing immunofluorescence. tyloxapol 14-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-43 33981577-20 2021 Molecularly, we found that tyloxapol suppresses RANKL-stimulated NF-kappaB activation through suppressing degradation of IkappaBalpha, phosphorylation and nuclear translocation of p65. tyloxapol 27-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 180-183 33684389-4 2021 The lactucopicrin effect was not due to modulation of inhibitor of NF-kappaB kinases (IKK) alpha/beta/gamma, inhibitor of NF-kappaB alpha (IkappaBalpha), and NF-kappaB/p65 DNA binding activity. intybin 4-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 168-171 33710654-6 2021 The results demonstrate that PQQ prolongs TTE, causes the decrease in the activity of serum creatine kinase and lactate dehydrogenase, increases the activity of antioxidant enzymes, inhibits the production of reactive oxygen species (ROS) and malondialdehyde (MDA), and diminishes the over expression of NF-kappaB (p65) and inflammatory mediators. PQQ Cofactor 29-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 315-318 32852718-5 2021 Moreover, we found that hexahydrocurcumin treatment could decrease interleukin-6 levels by attenuating p65 of nuclear factor kappa-light-chain-enhancer (NF-kappaB) of activated beta cells. hexahydrocurcumin 24-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 103-106 33734700-8 2021 In addition, gliadin-induced intestinal barrier impairment was blocked by l-arabinose treatment via regulation of TJ proteins and suppression of p38 MAPK and p65 NF-kappaB inflammation signaling pathways. Arabinose 74-85 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 158-171 33645621-7 2021 In addition, ACG treatment remarkably down-regulated the expression of TLR4, p-P65, NLRP3, Caspase-1 and adenosquamous carcinoma (ASC) in lung tissue. acg 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 79-82 33496702-7 2021 We also measured the expression of the phosphorylation of p65, IkappaB, p38, ERK and JNK protein and found that SES can alleviate colon damage via the NF-kappaB and MAPK signaling pathways. sesamin 112-115 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 58-61 33751905-8 2021 Consistent with these in vivo findings, ARN treatment significantly decreased the phosphorylation of p65 in LPS-stimulated RAW 264.7 macrophages and BMDMs. arn 40-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 33842604-11 2021 Rosavin inhibited RANKL-induced phosphorylation of p65 and inhibitory subunit of NF-kappaB alpha (IkappaBalpha), and suppressed p65 nuclear translocation. rosavin 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 33842604-11 2021 Rosavin inhibited RANKL-induced phosphorylation of p65 and inhibitory subunit of NF-kappaB alpha (IkappaBalpha), and suppressed p65 nuclear translocation. rosavin 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-131 33383371-11 2021 BBD inhibited the activation of mouse primary BMDMs/PMs/microglia/astrocytes by regulating TLR4 pathway involving the phosphorylation of P65, JNK, ERK and P38. 5-tert-butyl-1,3-benzodioxole 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 137-140 33512774-8 2021 Cisplatin treatment caused increased caspase 3 cleavage and p65 phosphorylation, elevated serum urea nitrogen and creatinine, and obvious histological damage of kidney such as fractured tubules in control mice, which were enhanced in HNF1beta knockdown mice. Cisplatin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 60-63 33091501-10 2021 Physalin A remarkably blocked the degradation of inhibitor of nuclear factor kappa B alpha (IkappaB-alpha) and the nuclear translocation of nuclear factor-kappaB (NF-kappaB) p65 induced by LPS in RAW 264.7 cells. physalin A 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 174-177 33495830-8 2021 HMPH significantly inhibited the translocation of p65 NF-kappaB into the nucleus to a greater extent than curcumin, thus indicating that HMPH has more potent anti-inflammatory activity than curcumin. 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 50-63 33340447-0 2021 Nicotinamide mononucleotide (NMN) protects bEnd.3 cells against H2 O2 -induced damage via NAMPT and the NF-kappaB p65 signalling pathway. Nicotinamide Mononucleotide 0-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-117 33340447-0 2021 Nicotinamide mononucleotide (NMN) protects bEnd.3 cells against H2 O2 -induced damage via NAMPT and the NF-kappaB p65 signalling pathway. Nicotinamide Mononucleotide 29-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-117 33340447-0 2021 Nicotinamide mononucleotide (NMN) protects bEnd.3 cells against H2 O2 -induced damage via NAMPT and the NF-kappaB p65 signalling pathway. Hydrogen Peroxide 64-69 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-117 33785094-9 2021 Moreover, the results from mice model and cell model showed that quercetin could diminish IkappaBalpha and p65 phosphorylation after LPS treatment. Quercetin 65-74 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-110 33495830-8 2021 HMPH significantly inhibited the translocation of p65 NF-kappaB into the nucleus to a greater extent than curcumin, thus indicating that HMPH has more potent anti-inflammatory activity than curcumin. 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one 137-141 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 50-63 33495830-8 2021 HMPH significantly inhibited the translocation of p65 NF-kappaB into the nucleus to a greater extent than curcumin, thus indicating that HMPH has more potent anti-inflammatory activity than curcumin. Curcumin 190-198 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 50-63 33495830-10 2021 In conclusion, HMPH may be considered a promising compound for reducing inflammation via targeting p65 NF-kappaB translocation and interfering with MD2 binding. 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one 15-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-112 33125461-7 2021 Moreover, alogliptin reversed LPS-induced increases in toll-like receptor 4 (TLR4) and myeloid differentiation primary response 88 (MYD88) protein expression, nuclear factor-kappaB (NF-kappaB) p65 content, and microRNA-155 (miRNA-155) gene expression. alogliptin 10-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 193-196 33664740-6 2020 In addition, the activation of nuclear factor kappa B (NF-kappaB; p65 and IkappaBalpha) signaling was significantly suppressed by taxifolin supplementation. taxifolin 130-139 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 32935630-11 2021 In addition, p65 phosphorylation at Ser-276 induced acetyl transferase p300 recruitment, leading to its acetylation on Lys-310 and thereby enhancing its transcriptional activity. Serine 36-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 13-16 33340782-7 2021 Molecular studies revealed that BAK inhibited the activation of upstream mediator nuclear factor-kappaB by suppressing the phosphorylation of IkappaBalpha and p65. bakuchiol 32-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 159-162 33708430-0 2021 Combined targeting of vascular endothelial growth factor C (VEGFC) and P65 using miR-27b-3p agomir and lipoteichoic acid in the treatment of gastric cancer. mir-27b 81-88 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 71-74 32942003-9 2021 Furthermore, chloroquine treatment exacerbated IR-induced p65 nuclear translocation, IkappaBalpha degradation, and transcription of NF-kappaB target genes in peritoneal macrophages. Chloroquine 13-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 58-61 32935630-11 2021 In addition, p65 phosphorylation at Ser-276 induced acetyl transferase p300 recruitment, leading to its acetylation on Lys-310 and thereby enhancing its transcriptional activity. Lysine 119-122 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 13-16 32935630-14 2021 Moreover, chromatin immunoprecipitation and the knock-down experiments revealed that p65 is a nuclear effector of TSH actions, inducing the transcripcional expression of thyroid differentiation markers. Thyrotropin 114-117 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 85-88 33496741-6 2021 Levels of HUWE1 and miR-98 were decreased, and p65 levels were increased in the lungs of SS mice in vivo and in hemin-treated human pulmonary artery endothelial cells (HPAECs) in vitro. Hemin 112-117 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 47-50 33481000-11 2021 Mechanically, SRT1720 administration inhibited p65 phosphorylation in the lung tissues of ARDS mice. SRT1720 14-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 47-50 33377310-6 2021 Instead, the lactucopicrin effect was reliant on the inhibition of cytoplasmic dynein-mediated p65 transportation, a prerequisite step for p65 nuclear translocation. intybin 13-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-98 33377310-6 2021 Instead, the lactucopicrin effect was reliant on the inhibition of cytoplasmic dynein-mediated p65 transportation, a prerequisite step for p65 nuclear translocation. intybin 13-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 139-142 32859792-10 2021 Furthermore, administration of the MAP4K4 inhibitor PF-06260933 reduced blood-brain barrier damage in mice, promoted the recovery of neurological function, and reduced p-p65 and MMP9 protein expression. PF-6260933 52-63 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 170-173 33227274-7 2021 And the inflammatory signal such as p-IKBalpha and p-p65 was correspondingly inhibited by conbercept in STZ-treated mice. Streptozocin 104-107 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 33188837-13 2021 Both miR-548b-3p overexpression and KPNA4 downregulation inhibited tumor growth and Ki-67 expression, elevated numbers of Tunel-positive cells, and deceased nuclear p65 expression in mouse tumor tissues. mir-548b 5-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 165-168 33447908-7 2021 NF-kappaB (P65) mRNA expression and the phosphorylation of p65 were increased in Mn-treated BV2 cell, and suppressed by PAS-Na, analogous to the effect of JSH-23 pretreatment. Protactinium 120-123 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 11-14 33447908-7 2021 NF-kappaB (P65) mRNA expression and the phosphorylation of p65 were increased in Mn-treated BV2 cell, and suppressed by PAS-Na, analogous to the effect of JSH-23 pretreatment. Protactinium 120-123 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-62 33402180-11 2021 Furthermore, GM up-regulated the expression of antioxidant protein Nrf2 and inhibited the expression of inflammatory response protein p-p65. germacrone 13-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-139 32535239-15 2021 We also found that the combination of JF and DT inhibits TLR4/PI3K/AKT/mTOR signaling-related proteins expression level (including TLR, p- PI3K p110alpha/PI3K p110alpha, p-AKT (ser473)/AKT, mTOR, p-mTOR, NF-kappaB p65), it shows an effective anti-inflammatory effect. jf 38-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 214-217 32535239-15 2021 We also found that the combination of JF and DT inhibits TLR4/PI3K/AKT/mTOR signaling-related proteins expression level (including TLR, p- PI3K p110alpha/PI3K p110alpha, p-AKT (ser473)/AKT, mTOR, p-mTOR, NF-kappaB p65), it shows an effective anti-inflammatory effect. Thymidine 45-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 214-217 32865668-11 2021 Olaparib decreased PARylated protein content and p65, IkappaBalpha phosphorylation in IAV lung tissues. olaparib 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 49-52 33321327-9 2021 Inhibition of HDAC6 suppressed nicotine-induced pyroptosis, which is partly mediated by p65 acetylation and NLRP3 transcription. Nicotine 31-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 33747866-8 2021 In contrast, PGV-1 neither inhibited localization nor decreased the expression of HER2, nonetheless showed the most potent inhibition against nuclear localization of p65 indicating the different mechanisms of curcumin, PGV-0, and PGV-1. Curcumin 209-217 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 166-169 32303879-11 2021 Montelukast mitigated THIM-induced social deficit probably through alpha7nAChRs upregulation, NF-kappaB p65, Bax, and brain injury markers downregulation, thus suppressing THIM-induced neuronal toxicity and inflammation. montelukast 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 104-107 33303231-8 2021 LTA- and LPS-stimulated expression of the redox-sensitive transcription factor NF-alphaB (p65) in cell nuclei decreased in the presence of HEMA because the translocation of p65 from the cytosol was prevented by oxidative stress specifically increased by the monomer. lipoteichoic acid 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 79-94 33303231-8 2021 LTA- and LPS-stimulated expression of the redox-sensitive transcription factor NF-alphaB (p65) in cell nuclei decreased in the presence of HEMA because the translocation of p65 from the cytosol was prevented by oxidative stress specifically increased by the monomer. lipoteichoic acid 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-93 33191175-11 2021 Furthermore, MitoQ suppressed IkappaBalpha degradation and NF-kappaB p65 nuclear translocation. mitoquinone 13-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-72 32927162-0 2021 Augmented autophagy suppresses thymocytes development via Bcl10/p-p65 pathway in prenatal nicotine exposed fetal mice. Nicotine 90-98 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 32927162-11 2021 In addition, nicotine-inhibited CD69-CD4+SP cells and the Bcl10/p-p65 pathway have been reversed by an autophagy inhibitor. Nicotine 13-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 33326684-9 2021 MET and CGA combination treatment resulted in the polarization of macrophages to the M2 phenotype, reduction of the expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6), and decreasing protein level of NF-kB p65. Chlorogenic Acid 8-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 227-230 32865324-7 2021 Research on mechanisms found that palmatine could significantly inhibit the protein levels of p-Akt, p-P65, p-ERK1/2 and p-P38 in EpH4-Ev cells. palmatine 34-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 103-106 33653497-7 2021 Apigenin reduced the hypoxia/reoxygenation-induced cell inflammatory injury and NF- B p65 nuclear translocation from cytoplasm and activation. Apigenin 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 86-89 32761488-8 2021 In addition, TLR4, myeloid differentiation primary response gene 88 (MyD88), p-IKKbeta, p-p65, and NF-kappaB p65 in nuclei levels were significantly reduced by dioscin. dioscin 160-167 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-93 33277208-14 2021 Further, the IL6/STAT3/P65 signaling pathway was inhibited in the EVO group. evodiamine 66-69 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 23-26 32761488-8 2021 In addition, TLR4, myeloid differentiation primary response gene 88 (MyD88), p-IKKbeta, p-p65, and NF-kappaB p65 in nuclei levels were significantly reduced by dioscin. dioscin 160-167 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-112 33339187-8 2020 Regarding the molecular mechanism, eudebeiolide B inhibited the phosphorylation of Akt and NF-kappaB p65. eudebeiolide 35-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 33212164-4 2021 The current study aimed at investigating the effects of in utero VPA exposure on the key components of the NF-kappaB signaling pathway including p65, p50, and Pim-1 in CD-1 mouse embryos during the critical period of neural tube closure. Valproic Acid 65-68 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 145-148 33212164-5 2021 Here we report that p65, Pim-1 and p105/p50 mRNA were significantly (p < 0.05) downregulated at 1 and 3 h following in utero exposure to a teratogenic dose (400 mg/kg) of VPA in gestational day (GD)9 exposed embryos. Valproic Acid 171-174 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 20-23 33212164-8 2021 The reported results suggest that VPA exposure perturbates p65, p105/p50, Pim-1 transcript and p65/p50 protein levels in mouse embryos. Valproic Acid 34-37 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-62 33212164-8 2021 The reported results suggest that VPA exposure perturbates p65, p105/p50, Pim-1 transcript and p65/p50 protein levels in mouse embryos. Valproic Acid 34-37 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-98 33290778-5 2021 Arsenic exposure induced hepatic injury and resulted in the activations of p-AKT2, NF-kappaB p65, and NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, downregulation of Sema 3A, and upregulation of Sema 4A or NRP-1. Arsenic 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 93-96 33344446-13 2020 The AKT activator SC79 and p65 inhibitor Bay 11-7082 reduced H2O2-induced cell apoptosis and hypertrophy. 3-(4-methylphenylsulfonyl)-2-propenenitrile 41-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 27-30 33363184-10 2020 Parallel to down-regulation of the inflammatory cytokines, the fecal lipocalin 2, p-P65, p-STAT3, and neutrophil accumulation were also decreased in TS-treated mice. ts 149-151 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 33327537-6 2020 In addition, 5 g/L lincomycin exposure reduced the villus height, crypt depth, and relative expression of TLR2, TLR3, TLR4, IL-18, TNF-alpha, and p65 in the jejunum of mice (p < 0.05), while 1 g/L lincomycin exposure reduced the relative expression of TLR2, TLR3, TNF-alpha, and p65 (p < 0.05). Lincomycin 19-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 146-149 33327537-6 2020 In addition, 5 g/L lincomycin exposure reduced the villus height, crypt depth, and relative expression of TLR2, TLR3, TLR4, IL-18, TNF-alpha, and p65 in the jejunum of mice (p < 0.05), while 1 g/L lincomycin exposure reduced the relative expression of TLR2, TLR3, TNF-alpha, and p65 (p < 0.05). Lincomycin 19-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 279-282 33344446-13 2020 The AKT activator SC79 and p65 inhibitor Bay 11-7082 reduced H2O2-induced cell apoptosis and hypertrophy. Hydrogen Peroxide 61-65 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 27-30 33068864-5 2020 Hesperetin suppresses the acetylation of RelA/p65 to reduce NF-kappaB activity by inducing SIRT1 expression. hesperetin 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 41-45 33059262-0 2020 Anterior gradient 2 is a novel pro-tumor factor in pancreatic cancer under NF-kappaB subunit RelA trans-regulation that can be suppressed by eugenic acid. Eugenol 141-153 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 93-97 33059262-7 2020 Furthermore, EA downregulated the expression of AGR2 in pancreatic cancer cells via the RelA binding site. ea 13-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-92 33039967-10 2020 Furthermore, alpinetin inhibited OVA-induced phosphorylation of p65, IkappaB, PI3K and AKT, and the activity of HO-1 in vivo. alpinetin 13-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-67 33068864-5 2020 Hesperetin suppresses the acetylation of RelA/p65 to reduce NF-kappaB activity by inducing SIRT1 expression. hesperetin 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 46-49 33246465-2 2020 We showed that the sinergistic combination of the histone deacetilase inhibitor MS-275 with the sirtuin 1 activator resveratrol, at very low doses, restores normal RelA acetylation and elicit neuroprotection in mice subjected to transient middle cerebral artery occlusion (tMCAO) and primary cortical neurons exposed to oxygen-glucose-deprivation (OGD). entinostat 80-86 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 164-168 33354662-5 2020 Internal Coordinates Mechanics analysis suggested direct binding between CU-O75 and IkappaBalpha/p50/p65 which leads to the stabilization of the NF-kappaB trimer. Copper 73-75 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-104 33354662-6 2020 A whole cellular thermal shift assay confirmed direct binding of the NQBS to IkappaBalpha, an inhibitory component of the IkappaBalpha/p50/p65 trimer. nqbs 69-73 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-142 33312069-10 2020 Mechanistic studies using Western blotting demonstrated that Tet inhibited the nuclear factor (NF)-kappaB signaling pathway by decreasing the phosphorylation of inhibitor of NF-kappaB alpha (IkappaBalpha) and p65, which play important roles in osteoclast formation. tetrandrine 61-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 209-212 32980473-9 2020 Moreover, the western blot results indicated that Cl-amidine decreased the phosphorylation of IkappaB, p65, p38, ERK and the expression of NLRP3 in LPS-induced mouse mastitis. N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide 50-60 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 103-106 32943552-6 2020 We further showed that low-dose naltrexone (LDN) abrogates hyperinsulinemia-mediated SIRT1 repression and prevents NF-kappaB p65 nuclear translocation. Naltrexone 32-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 125-128 33246465-2 2020 We showed that the sinergistic combination of the histone deacetilase inhibitor MS-275 with the sirtuin 1 activator resveratrol, at very low doses, restores normal RelA acetylation and elicit neuroprotection in mice subjected to transient middle cerebral artery occlusion (tMCAO) and primary cortical neurons exposed to oxygen-glucose-deprivation (OGD). Resveratrol 116-127 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 164-168 33202848-6 2020 Furthermore, all the six flavonoids could significantly inhibit the secretion of IL-1beta, IL-6, NO (p < 0.01) and the protein expression of NF-kappaB p-p65 (p < 0.01) in LPS-stimulated RAW264.7 cells. Flavonoids 25-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 153-156 34026223-13 2021 Sodium butyrate downregulated some elements of the TLR4/NF-kappaB pathway, including phospho-IkappaBalpha and phospho-p65, in RAW264.7 cells. Butyric Acid 0-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-121 33177483-9 2020 RESULTS In the DSS mouse model of IBD, rifaximin reduced the inflammation severity of the colon and reduced the expression of phospho-p65, p65, TNF-alpha, and IL-6. Rifaximin 39-48 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 134-137 33177483-9 2020 RESULTS In the DSS mouse model of IBD, rifaximin reduced the inflammation severity of the colon and reduced the expression of phospho-p65, p65, TNF-alpha, and IL-6. Rifaximin 39-48 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 139-142 32946950-7 2020 Meanwhile, UA treatment inhibited glial activation via affecting inflammatory signaling pathways, specifically by enhancing cerebral AMPK and IkappaBa activation while decreasing the activation of Akt, P65NFkappaB, ERK, JNK, and P38MAPK. 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one 11-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 202-213 33171990-5 2020 In the retinas of high-dose COS-treated mice, the nuclear translocation of NF-kappaB subunit (p65) was suppressed, and the expression of several key EAU inflammatory mediators, IFN-gamma, TNF-alpha, IL-1alpha, IL-4, IL-5, IL-6, IL-10, IL-17 and MCP-1 was lowered. carbonyl sulfide 28-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 75-98 33153477-12 2020 BMAA treatment also activated neuronal extracellular TLR4 and intracellular TLR3, inducing p65 NF-kappaB translocation into the nucleus and activating the transcription of NLRP3 and pro-IL-1beta. beta-N-methylamino-L-alanine 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-104 33182048-12 2020 Meanwhile, emodin effectively inhibited NF-kappaB pathway activation and attenuated p65 DNA binding activity induced by LPS inhalation. Emodin 11-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 33313242-15 2020 Meanwhile, GB inactivated the expression levels of Wnt5a, phosphorylated (p)-JNK, and p-P65 in the synovial tissues and RA-FLSs. ginkgolide B 11-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 33043521-6 2020 The nuclear factor-kappa B (NF-kappaB) p65 pathway was inhibited by JSH-23, and the results showed that treatment with JSH-23 inhibited M1 macrophage differentiation and alleviated cardiac injury in LPS-treated IL-5-knockout mice. 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine 68-74 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 39-42 33043521-6 2020 The nuclear factor-kappa B (NF-kappaB) p65 pathway was inhibited by JSH-23, and the results showed that treatment with JSH-23 inhibited M1 macrophage differentiation and alleviated cardiac injury in LPS-treated IL-5-knockout mice. 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine 119-125 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 39-42 32745764-3 2020 Moreover, NFkappaB-luciferase activity was elevated in cardiomyocytes after simulated ischemia/reperfusion (sI/R) or doxorubicin (DOX) treatment, and inhibition of NFkappaB with Ad-p65-shRNA or Ad-IkappaBalphaM diminished sI/R- and DOX-induced cell death and HMGB1 release. Doxorubicin 117-128 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 181-184 32745764-3 2020 Moreover, NFkappaB-luciferase activity was elevated in cardiomyocytes after simulated ischemia/reperfusion (sI/R) or doxorubicin (DOX) treatment, and inhibition of NFkappaB with Ad-p65-shRNA or Ad-IkappaBalphaM diminished sI/R- and DOX-induced cell death and HMGB1 release. Doxorubicin 130-133 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 181-184 33182072-7 2020 In the LPS-induced inflammatory response of RAW264.7 macrophages, we also found that PE significantly inhibited the phosphorylation of AKT, ERK1/2, JNK1/2, P65, and P38 to reduce the production of IL-1beta, IL-6, TNF-alpha, COX-2, and iNOS. pedunculoside 85-87 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 156-159 32889238-0 2020 PAD4 selective inhibitor TDFA protects lipopolysaccharide-induced acute lung injury by modulating nuclear p65 localization in epithelial cells. TDFA 25-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 106-109 33113116-10 2021 In fluoride-treated mouse odontoblasts, the effect of fluoride was further seen in the upstream of RUNX2 as the reduced nuclear translocation of beta-catenin and phosphorylated p65/NFkappaB. Fluorides 3-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 177-180 32853627-6 2020 This combination T317 + DAPT treatment was also linked with a significant upregulation of ABCA1 and the stimulation of reverse cholesterol transport (RCT), as well as with decreases in the levels of intercellular cell adhesion molecule-1 (ICAM-1) and p-p65, and with altered M1/M2 macrophage proportions within atherosclerotic plaques. Pararosaniline hydrochloride 17-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 253-256 32853627-6 2020 This combination T317 + DAPT treatment was also linked with a significant upregulation of ABCA1 and the stimulation of reverse cholesterol transport (RCT), as well as with decreases in the levels of intercellular cell adhesion molecule-1 (ICAM-1) and p-p65, and with altered M1/M2 macrophage proportions within atherosclerotic plaques. dapt 24-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 253-256 33113116-10 2021 In fluoride-treated mouse odontoblasts, the effect of fluoride was further seen in the upstream of RUNX2 as the reduced nuclear translocation of beta-catenin and phosphorylated p65/NFkappaB. Fluorides 54-62 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 177-180 33090427-10 2020 Likewise, the NF-kappaB/p65, JAK/STAT and TLR/MyD88 signaling pathways were inactivated upon pretreatment with UF010 and SAHA compared to MC1568. UF010 111-116 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 24-27 33081840-18 2020 Daphnetin was found to be able to inhibit p65 phosphorylation and nuclear translocation in HaCaT keratinocytes. daphnetin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 42-45 32871020-9 2020 Further, Sch suppresses phosphorylation of P65 and its nuclear translocation, as well as the degradation of IkappaBalpha. schizandrin A 9-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 43-46 32446898-7 2020 Furthermore, fucoidan administration retained p65/NF-kappaB transcription factor in the cytosol thereby showing down regulation of the gene expression of pro-inflammatory mediators such as IL-1beta, COX-2and MMP-9 in fucoidan treated mice. fucoidan 13-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 46-49 31970441-11 2020 At the same time, resveratrol reduced BUN, SCr, 24 h UMA and the expression of the inflammatory factors RAGE, NF-kB (P65) and NOX4 and improved the renal pathological structure. resveratrol 18-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-120 32605924-8 2020 We observed reduced nuclear translocation of the p65 subunit of NFkappaB in islets of MPE-treated db/db mice, coinciding with enhanced glucose-stimulated insulin secretion (GSIS). Glucose 135-142 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 49-52 32999298-10 2020 PM104 attenuated radiation-induced increases in NF-kappaB activity and inhibited radiation-induced p65 translocation, ROS production, DNA damage, and epithelial-mesenchymal transition. PM 104 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-102 32894174-9 2020 The attenuated phospho-p65 protein levels and the mRNA levels of pro-inflammatory cytokines (IL-6, IL-12 and TNF-alpha) were observed in the livers from fucoidan-treated S. japonicum-infected mice; however, the mRNA levels of anti-inflammatory cytokines (IL-4 and IL-13) were increased. fucoidan 153-161 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 23-26 32934775-3 2020 We demonstrate that the administration of BAY 11-7082, either before or after acidic bile, eliminates NF-kappaB activation, prevents overexpression of Bcl2, Rela, Stat3, Egfr, Tnf, Wnt5a, and deregulations of miR-192, miR-504, linked to bile reflux-related hypopharyngeal cancer. 3-(4-methylphenylsulfonyl)-2-propenenitrile 42-53 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 157-161 32554052-4 2020 Eomes promoted the interaction of RelA and NFATc2 with the Ifng promoter and five CNS, including CNS-22 and CNS + 30 upon stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM). Tetradecanoylphorbol Acetate 139-170 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 34-38 32554052-4 2020 Eomes promoted the interaction of RelA and NFATc2 with the Ifng promoter and five CNS, including CNS-22 and CNS + 30 upon stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM). Tetradecanoylphorbol Acetate 172-175 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 34-38 32554052-4 2020 Eomes promoted the interaction of RelA and NFATc2 with the Ifng promoter and five CNS, including CNS-22 and CNS + 30 upon stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM). Ionomycin 181-190 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 34-38 32554052-4 2020 Eomes promoted the interaction of RelA and NFATc2 with the Ifng promoter and five CNS, including CNS-22 and CNS + 30 upon stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM). Ionomycin 192-194 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 34-38 32705184-7 2020 However, phosphorylated beta-catenin and p65 levels significantly increased after STZ stimulation, compared with untransduced cells. Streptozocin 82-85 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 41-44 32203080-10 2020 CAG also inhibited NF-kappaB p65 nuclear translocation. cycloastragenol 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 29-32 32535536-8 2020 Then we found that Hig suppressed NF-kappaB signaling pathway by inhibiting nuclear translocation of NF-kappaB/p65 subunit as well as degradation and phosphorylation of IkappaBalpha in cytoplasm, and the effect of Hig was intimately related to NF-kappaB inhibitor BAY-11-7082. higenamine 19-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 111-114 32953791-10 2020 After the addition of celastrol, MCL treatment significantly reduced the levels of p-p65, NLRP3, caspase-1, and ASC. celastrol 22-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 85-88 32281710-5 2020 Furthermore, increased inflammation and apoptosis were observed in the tissues of DSS-induced colitis mice, with increased expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), phosphorylation of nuclear factor kappa B (NF-kappaB)-p65 (p-NF-kB-p65) and cleaved caspase-3, and decreased expression of tight junction (TJ) proteins such as zonula occluden-1 (ZO-1) and occludin. dss 82-85 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 254-257 32615888-5 2020 Western blot analysis indicated that Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3, p-65-NF-kappaB and cell apoptosis pathways were activated by LPS but suppressed by Curcumin. Curcumin 200-208 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-131 32615888-7 2020 Moreover, PDTC, AG-490 and Curcumin all significantly reversed the previously increased expressions of p-JAK2/STAT3, p-p65 and proapoptotic proteins in the mice with AKI. prolinedithiocarbamate 10-14 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-122 32615888-7 2020 Moreover, PDTC, AG-490 and Curcumin all significantly reversed the previously increased expressions of p-JAK2/STAT3, p-p65 and proapoptotic proteins in the mice with AKI. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 16-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-122 32615888-7 2020 Moreover, PDTC, AG-490 and Curcumin all significantly reversed the previously increased expressions of p-JAK2/STAT3, p-p65 and proapoptotic proteins in the mice with AKI. Curcumin 27-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-122 32125592-8 2020 In addition, NaBu administration decreased the concentration of proteins p65 and p50 in the nucleus as compared with the cytoplasm by western blot analysis. sethoxydim 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-76 32450529-11 2020 Indeed, both alkaloids reduced the NF-kB (p65) activation on granulocytes and lymphocytes, indicating that the alkaloids shut down the intracellular transduction signals underlie the transcription of TH2 cytokine gens. Alkaloids 13-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 35-46 32449271-10 2020 AAs reversed rotenone-induced effects on lipoperoxidation, NO production, and GSH/GSSG ratio, as well as increased TH and attenuated pro-IL-1beta and MMP-9 levels in both regions, NF-kB-p65 in the SN and GFAP in the striatum. Rotenone 13-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 186-189 32164488-7 2020 Moreover, the addition of budesonide or hesperidin reliably accelerated the expression levels of PGC-1alpha and SIRT1 but suppressed the phosphorylation of p65 in COPD mice. Budesonide 26-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 156-159 32164488-7 2020 Moreover, the addition of budesonide or hesperidin reliably accelerated the expression levels of PGC-1alpha and SIRT1 but suppressed the phosphorylation of p65 in COPD mice. Hesperidin 40-50 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 156-159 31972207-8 2020 Additionally, curcumin reduced the LPS-induced increase in Bax, cleaved-caspase3/caspase 3, p-IkBalpha/IkBalpha, p-p65/p65, p-JNK/JNK, and p-c-JUN/c-JUN protein expression, and increased Bcl2 protein expression in NRK cells. Curcumin 14-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 115-118 32801992-4 2020 Aplysin intervention was able to alleviate spontaneous pancreatic necrosis in NOD mice, accompanied with decreased serum endotoxin levels and downregulated expressions of Toll-like receptor 4 and its related molecules MyD88, TRAF-6, NF-kappaB p65, TRIF, TRAM, and IRF-3, as well as protein levels of interleukin-1beta and interferon-beta in pancreatic tissues. aplysin 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 243-246 32640590-6 2020 LPS-induced cytosolic reactive oxygen species (cROS) oxidized PP2A, a serine/threonine phosphatase, leading to the activation of IKKalpha/beta, followed by the nuclear localization of p65. Reactive Oxygen Species 22-45 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 184-187 32468017-8 2020 Furthermore, pre-treatment with TA suppressed the production of pro-inflammatory markers, as well as the nuclear translocation of nuclear factor-kappaB (NF-kappaB) p65 induced by Abeta exposure in BV2 cells. euscaphic acid 32-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 164-167 32461025-5 2020 In vitro, Nurr1 expression and nuclear translocation decreased in Muller cells exposed to high glucose levels; therefore, p65 was activated, and the downstream NLRP3 inflammasome was up-regulated via the interaction of p65 with its promoter. Glucose 95-102 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-125 32461025-5 2020 In vitro, Nurr1 expression and nuclear translocation decreased in Muller cells exposed to high glucose levels; therefore, p65 was activated, and the downstream NLRP3 inflammasome was up-regulated via the interaction of p65 with its promoter. Glucose 95-102 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 219-222 32850781-10 2020 In cocaine administered mice, EV-Cy5-miR-124 delivered intranasally were detected in the CNS and significantly reduced the expression of inflammatory markers TLR4, MYD88, STAT3 and NF-kB p65 while also downregulating the microglial activation marker, Iba1. ev-cy5-mir-124 30-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 187-190 32724493-15 2020 As expected, the addition of NAC efficiently suppresses the TNF-alpha and IL-6 secretion stimulated from PQ and also downregulated ERK, JNK, and p65 phosphorylation (ERK/JNK MAPK and NF-kappaB pathways) as well as MUC5B expression. Acetylcysteine 29-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 145-148 32376269-13 2020 We further revealed that Eupatilin abolished MPTP-induced downregulation of IkappaBalpha expression and accumulation of p65 in the nuclear compartment. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 45-49 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 120-123 32640590-6 2020 LPS-induced cytosolic reactive oxygen species (cROS) oxidized PP2A, a serine/threonine phosphatase, leading to the activation of IKKalpha/beta, followed by the nuclear localization of p65. Serine 70-76 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 184-187 32640590-8 2020 Consequently, DAC reduced the phosphorylation of IKKalpha/beta to block the nuclear localization of p65, which decreased NF-kappaB activation. dauricine 14-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 100-103 32278007-7 2020 Furthermore, DPLG3 reduced the protein levels of the canonical NF-kappaB p50 and p65, as well as the nuclear p65. dplg3 13-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 81-84 32632306-0 2020 Spermidine activates RIP1 deubiquitination to inhibit TNF-alpha-induced NF-kappaB/p65 signaling pathway in osteoarthritis. Spermidine 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 32632306-7 2020 In terms of the mechanism, 9 muM spermidine did not affect the viability, proliferation, cell cycle and apoptosis of H-FLS, and exerted inhibitory effects by activating CYLD-mediated RIP1 deubiquitination on TNF-alpha-induced NF-kappaB/p65 signaling in H-FLS. Spermidine 33-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 236-239 32692218-7 2020 In addition, 6-gingerol could suppress the phosphorylation level of IkappaBalpha and p65, which was up-regulated by DSS. gingerol 13-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 85-88 32692218-7 2020 In addition, 6-gingerol could suppress the phosphorylation level of IkappaBalpha and p65, which was up-regulated by DSS. Dextran Sulfate 116-119 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 85-88 32692218-8 2020 Further analysis with immunohistochemistry indicated p-p65 staining was mainly in the nucleus with some in the cytoplasm after DSS treatment, and the treatment with 6-gingerol could significantly weaken the density of p-p65 both in the cytoplasm and nucleus. Dextran Sulfate 127-130 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 32692218-8 2020 Further analysis with immunohistochemistry indicated p-p65 staining was mainly in the nucleus with some in the cytoplasm after DSS treatment, and the treatment with 6-gingerol could significantly weaken the density of p-p65 both in the cytoplasm and nucleus. gingerol 165-175 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 32692218-8 2020 Further analysis with immunohistochemistry indicated p-p65 staining was mainly in the nucleus with some in the cytoplasm after DSS treatment, and the treatment with 6-gingerol could significantly weaken the density of p-p65 both in the cytoplasm and nucleus. gingerol 165-175 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 220-223 32247937-5 2020 TAT peptide conjugated on mesoporous silica nanoparticles (MSN) help non-endocytosis cell-membrane transducing and converge toward perinuclear region, where the p65 specific antibody performed the targeting and catching against active NF-kappaB p65 effectively. Silicon Dioxide 37-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 161-164 32278007-7 2020 Furthermore, DPLG3 reduced the protein levels of the canonical NF-kappaB p50 and p65, as well as the nuclear p65. dplg3 13-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-112 33040725-9 2020 Molecular analysis demonstrated that 50 mM glucose upregulated phosphorylation of the NFkappaB heterodimer p65 subunit in the cells grown on the glass support. Glucose 43-50 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-110 32030812-8 2020 Application of topical curcumin also increased the expression level of RelA as the main subunit of the nuclear factor-kappaB (NF-kappaB) signalling pathway. Curcumin 23-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 71-75 32676468-5 2020 KDE also suppressed LPS-induced phosphorylation of p65, IkappaB kinase, and p38 in RAW 264.7 cells. KDE 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 32325405-7 2020 Besides, bilirubin inhibited the secretion of TNF-alpha and IL-6 in LPS-primed macrophages by reduced phosphorylation of IkappaB-alpha and p65, indicating the inhibition of the NF-kappaB pathway. Bilirubin 9-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 139-142 32515468-8 2020 Mechanically, we noticed that cimifugin inhibited IMQ-activated phosphorylation of NF-kappaB (IkappaB and p65) and MAPK (JNK, ERK and p38) signaling pathways. cimifugin 30-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 106-109 32530032-6 2020 Furthermore, GLP administration reversed the attenuated expression of CARD9, p-Syk and p-p65, and increased indoleamine 2, 3-dioxygenase (IDO) protein expression in MDSCs of LLC-bearing mice. glp 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 89-92 32676468-6 2020 Through Western blot assays and immunofluorescence results, we showed that KDE suppresses LPS-induced p65 translocation from cytosol to the nucleus in RAW 264.7 cells. KDE 75-78 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-105 32676468-9 2020 KDE may act by suppressing iNOS expression and subsequent NO production by inhibiting phosphorylation of p65 and p38 and suppressing translocation of p65 from the cytosol to the nucleus. KDE 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 105-108 32676468-9 2020 KDE may act by suppressing iNOS expression and subsequent NO production by inhibiting phosphorylation of p65 and p38 and suppressing translocation of p65 from the cytosol to the nucleus. KDE 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 150-153 32526922-5 2020 Furthermore, results of immunohistochemistry showed that the nuclear translocation of NF-kappaB/p65 and tyrosine nitration of cytoplasmic protein were stimulated by zoledronate, while MPMBP inhibited these phenomena, by acting as a superoxide anion (O2-) scavenger. Zoledronic Acid 165-176 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-99 32526922-5 2020 Furthermore, results of immunohistochemistry showed that the nuclear translocation of NF-kappaB/p65 and tyrosine nitration of cytoplasmic protein were stimulated by zoledronate, while MPMBP inhibited these phenomena, by acting as a superoxide anion (O2-) scavenger. mpmbp 184-189 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-99 32724636-8 2020 We also found that LPS stimulated the mouse macrophage cell line, Raw264.7, and secreted a tremendous level of proinflammatory cytokines and the secretion of these cytokines was reduced with EAA treatment via downregulation of mitogen-activated protein kinase phosphorylation and p65 translocation. Excitatory Amino Acids 191-194 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 280-283 32512874-7 2020 Our results also showed that the degradation of IkBa and nuclear translocation of the p65 subunit were blocked by scytonemin in LPS-stimulated RAW 264.7 cells. scytonemin 114-124 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 86-89 32193100-9 2020 Significantly, RSV improved the interaction between Sirt1 and p65, which may contribute to the decreased activity of NF-kappaB. Resveratrol 15-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 62-65 32272431-9 2020 At the molecular level, Western blot analysis indicated that shikonin inhibited the phosphorylation of inhibitor of NF-kappaB (IkappaB), P50, P65, extracellular regulated protein kinases (ERK), c-Jun N-terminal kinase (JNK), and P38. shikonin 61-69 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 142-145 32301543-8 2020 Further research proved that hemin repressed the inflammatory profiles in macrophages through inhibiting the translocation of NF-kappaB p65 by disrupting IRF5-NF-kappaB p65 complex formation in Spi-C-dependent way. Hemin 29-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-139 32220806-8 2020 Further, the restrain of p38 and p65 activation were also observed after andrographolide sulfonate administration. andrographolide sulfonate 73-98 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-36 32279044-6 2020 Furthermore, GL indirectly attenuated the expression of IL-1beta by directly inhibiting extracellular HMGB1 functions, which activated the NF-kappaB-p65/NLRP3/IL-1beta signalling pathway. Glycyrrhizic Acid 13-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 149-152 32499705-9 2020 Compared to the ISO group, the TA group had reduced levels of TLR4, p38, p-p38, NF-kappaB (p65), p-NF-kappaB (p-p65), caspase-3, Bax, and Bcl-2, as well as CK, CK-MB, and LDH. Tannins 31-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-94 31927655-12 2020 In addition, evaluation of protein expression showed that DEX blocked sepsis-activated JNK phosphorylation and NF-kappaB p65 nuclear translocation. Dexmedetomidine 58-61 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-124 31846070-5 2020 Extensive in vitro and preclinical research has demonstrated that niclosamide was found to exert potent anticancer and anti-inflammatory properties by targeting STAT3, p65 NF-kappaB, and NFATc-1 signaling paradigm with minimal host toxicity. Niclosamide 66-77 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 168-171 31846070-10 2020 Additionally, our results provided a preclinical rationale in imiquimod (IMQ)-induced BALB/c mouse model, where niclosamide diligently mitigated the IMQ-induced epidermal hyperplasia and inflammation by downregulating STAT3, p65 NF-kappaB, and NFATc-1 transcription factors along with Akt, Ki-67, and ICAM-1 protein expression. Niclosamide 112-123 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 225-228 32472295-9 2020 Furthermore, curcumin suppressed p-p65 expression via regulating miR-362-3p/TLR4 axis. Curcumin 13-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 35-38 32004976-13 2020 IL-17A, MPO-producing neutrophils, and NF-kappaB p65 expression in lungs of CLP mice decreased significantly after pretreatment with curcumin. Curcumin 133-141 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 49-52 32425778-9 2020 Western blotting showed that API promoted APAP-induced autophagy, activated the NRF2 pathway, and inhibited the transcriptional activation of nuclear p65 in the presence of APAP. Acetaminophen 42-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 150-153 31930775-7 2020 Furthermore, the NF-kappaB p65 expression in the nucleus in the SLE mice was decreased with the up-regulation of TUG1 expression and NF-kappaB p65 expression in the cytoplasm after PDTC treatment. pyrrolidine dithiocarbamic acid 181-185 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 27-30 31930775-7 2020 Furthermore, the NF-kappaB p65 expression in the nucleus in the SLE mice was decreased with the up-regulation of TUG1 expression and NF-kappaB p65 expression in the cytoplasm after PDTC treatment. pyrrolidine dithiocarbamic acid 181-185 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 143-146 32194087-9 2020 NMDEA suppressed the activation of IL-1beta and IL-6, in the hippocampus, and IL-1beta, IL-6, p65, and iNOS, in lipopolysaccharide (LPS)-induced BV-2 cells. nmdea 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 94-97 32073640-7 2020 In both KCs and T cells, DCAC treatment significantly downregulated Nrf2 and HO-1 expression along with induction of Keap-1, NF-kappaB (p65), TNF-alpha and iNOS, whereas pre-treatment of these cells with tBHQ attenuated these responses. Chlorides 25-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-139 32326535-7 2020 Additionally, phosphorylation of NF-kappaB subunits and upstream signaling molecules, including p65, p50, AKT, IkappaBalpha, and Src was downregulated by 200 muM of alverine in LPS-treated RAW264.7 cells. alverine 165-173 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-99 32326963-10 2020 During pathway analyses in vitro, the use of specific MAPK antagonists (SP600125, SB203580, and PD98059) revealed that JNK and p38 inhibition most efficiently attenuated LPA-induced phosphorylation of proinflammatory transcription factors (STAT1 and -3, p65, and c-Jun) and secretion of IL-6 and TNFalpha. lysophosphatidic acid 170-173 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 254-257 32331432-12 2020 Using a luciferase assay and western blot assay, we found that the NF-kappaB pathway was inhibited by Pg-EE, particularly by the decreased level of phosphorylated proteins of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) subunits (p65 and p50), inhibitor of kappa B alpha (IkappaBalpha), p85, and Src. pg-ee 102-107 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 239-300 32252398-6 2020 TQ-6 (2 muM) potently diminished inflammatory mediators (nitric oxide/inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2)) expression, nuclear factor kappa B (NF-kappaB) p65 phosphorylation, nuclear translocation, and hydroxyl radical (OH ) formation in LPS-stimulated microglia. tq-6 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 186-189 32109511-10 2020 Montelukast significantly reduced JNK level and NFkappaB p65 expression, and inhibited proinflammatory cytokines (TNF-alpha and IL-6) as well as oxidative stress (MDA, NO, and GSH). montelukast 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 57-60 32351323-11 2020 The compounds CUR and Pip also decreased the p65 protein phosphorylation of NF-kappa B and p38 (MAPK) in lung tissue. pip 22-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 45-48 32351323-13 2020 These effects found can be attributed to the ability of the new isolated compounds CUR and Pip to suppress p65 NF-kappaB and p-p38 MAPK pathways. pip 91-94 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-120 32260181-13 2020 Rb-ME also blocked MyD88-induced NF-kappaB promoter activity and nuclear translocation of NF-kappaB subunits (p65 and p50). rb-me 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 110-113 32144443-9 2020 Further, GA suppressed phosphorylation of p65NF-kappaB and IkappaBalpha along with down-regulation of IL-1beta/TNF-alpha/KC/MIP-2/GCSF genes. Gallic Acid 9-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 42-54 32043638-3 2020 Dietary administration of TMOP alleviated hyperuricemia and renal inflammation phenotypes, reprogramed uric acid metabolism pathways, inhibited the activation of NLRP3 inflammasome and TLR4/MyD88/NF-kappaB signaling pathways, and suppressed the phosphorylation of p65-NF-kappaB. tmop 26-30 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 264-277 32219583-6 2020 Kaempferol suppressed the Cisplatin induced infiltration of mononuclear cells, levels of TNF-alpha, iNOS, IL-12, activation of NF-kappaB, phosphorylation of IkappaBalpha and nuclear translocation of p65 in renal tissues. kaempferol 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 199-202 32489561-0 2020 Monascin ameliorate inflammation in the lipopolysaccharide-induced BV-2 microglial cells via suppressing the NF-kappaB/p65 pathway. monascin 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-122 32489561-10 2020 Furthermore, immunofluorescence staining showed that the translocation of NF-kappaB/p65 to the cellular nuclear was blockaded after Monascin treatment. monascin 132-140 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 32004931-12 2020 DMB attenuated all of these changes by reducing plasma TMAO levels, hence negatively inhibiting the p65 NF-kappaB signaling pathway and TGF-beta1/Smad3 signaling pathway. 3,3-dimethylbutan-1-ol 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 100-113 32157554-9 2020 Specifically, quercetin significantly inhibited LPS-induced upregulation of NF-kappa-B/P65(RELA), AP-1/C-JUN(JUN), cyclooxygenase-2(PTGS2), and interleukin 6(IL6) in mice myometrium on mRNA level and inhibited the upregulation of P65 and C-JUN on protein level. Quercetin 14-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 87-90 32157554-9 2020 Specifically, quercetin significantly inhibited LPS-induced upregulation of NF-kappa-B/P65(RELA), AP-1/C-JUN(JUN), cyclooxygenase-2(PTGS2), and interleukin 6(IL6) in mice myometrium on mRNA level and inhibited the upregulation of P65 and C-JUN on protein level. Quercetin 14-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-95 32157554-9 2020 Specifically, quercetin significantly inhibited LPS-induced upregulation of NF-kappa-B/P65(RELA), AP-1/C-JUN(JUN), cyclooxygenase-2(PTGS2), and interleukin 6(IL6) in mice myometrium on mRNA level and inhibited the upregulation of P65 and C-JUN on protein level. Quercetin 14-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 230-233 32219583-6 2020 Kaempferol suppressed the Cisplatin induced infiltration of mononuclear cells, levels of TNF-alpha, iNOS, IL-12, activation of NF-kappaB, phosphorylation of IkappaBalpha and nuclear translocation of p65 in renal tissues. Cisplatin 26-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 199-202 32273685-8 2020 Morusin also decreased IL-1beta-induced p65 phosphorylation and IkappaBalpha degradation. morusin 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-43 32035082-0 2020 The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitros. trovafloxacin 16-45 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 76-79 31866511-13 2020 Arg significantly decreased the phosphorylation of IKKbeta, IkappaBalpha and p65 in the cytoplasm of lung cancer cells by Western blotting assay, and remarkably reduced the release of p65 from the cytoplasm to the nucleus. arenobufagin 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-80 31866511-13 2020 Arg significantly decreased the phosphorylation of IKKbeta, IkappaBalpha and p65 in the cytoplasm of lung cancer cells by Western blotting assay, and remarkably reduced the release of p65 from the cytoplasm to the nucleus. arenobufagin 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 184-187 32035082-7 2020 The prolonged p65 translocation caused by TVX was associated with an increased phosphorylation of IKK and MAPKs and accumulation of inhibitors of NF-kappaB such as IkappaBalpha and A20 in HepG2. trovafloxacin 42-45 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 14-17 32194416-4 2020 In the current study, we found that BBR significantly decreased lipid accumulation, ameliorated reactive oxygen species (ROS) and lipid peroxides, Tumor necrosis factor alpha (TNF-alpha) expression, and phosphorylation of Nuclear factor kappa B (NF-kappaB) p65 both in vivo and in vitro. Berberine 36-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 257-260 31970695-8 2020 Erythropoietin, erythropoietin receptor, Bcl-2, and Bcl-xl mRNA expression were down-regulated, while phospho-Nf-kb p65 was up-regulated in ureteral epithelia following obstruction. phosphorylleucylphenylalanine 102-109 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 116-119 32036165-7 2020 Mechanistic approach indicated that TQ-4 inhibited the LPS-induced JNK phosphorylation, IkappaBalpha degradation, NF-kappaB p65 phosphorylation and its nuclear translocation, and hydroxyl radical (OH ) productions in RAW 264.7 cells. 1,2,4-triazino(6,1-b)quinazolone 36-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 124-127 31970695-9 2020 Erythropoietin treatment induced anti-apoptotic signaling via down-regulated Bax mRNA expression and abrogated phospho-Nf-kb p65. phosphorylleucylphenylalanine 111-118 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 125-128 31864092-8 2020 Importantly, DHEA blocked the nuclear translocation of p65 through down-regulation the IkappaB-alpha protein phosphorylation level in the mice stimulated with E. coli O157:H7. Dehydroepiandrosterone 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 31931366-5 2020 Western blotting analysis illustrated that DMB remarkably inhibited Con A-induced phosphorylation of IKK, IkappaB, NF-kappaB p65, ERK, JNK, p38 MAPK and STAT3 induced by Con A. demethyleneberberine 43-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 125-128 31713877-9 2020 In addition, cilostazol was found to attenuate the TNF-stimulated phosphorylation of mitogen activated protein kinase (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B cell (NF-kappaB) p65 in the aortic vascular smooth muscle cell line, MOVAS-1 and the D-gal plus TNF-challenged heart tissue of mouse. cilostazol 13-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 203-206 31999977-15 2020 CONCLUSION: We for the first time demonstrated that chrysoeriol ameliorates TPA-induced ear edema in mice, and that inhibition of JAK2/STAT3 and IkappaB/p65 NF-kappaB pathways are involved in the anti-inflammatory effects of chrysoeriol. chrysoeriol 52-63 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 153-166 31999977-12 2020 The compound lowered protein levels of phospho-p65 (Ser536), phospho-STAT3 (Tyr705), inducible nitric oxide synthases (iNOS), cyclooxygenase-2 (COX-2), interleukin 6 (IL-6), IL-1beta and tumor necrosis factor alpha (TNF-alpha) in mouse swollen ears. phosphorylleucylphenylalanine 39-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 47-50 32189993-11 2020 TVE is revealed to restore the native expression of AKT and p65. tve 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 60-63 31999977-14 2020 In addition, chrysoeriol decreased the production of NO and prostaglandin E2; inhibited the phosphorylation of inhibitor of kappaB (Ser32), p65 (Ser536) and Janus kinase 2 (Tyr1007/1008); decreased nuclear localization of p50, p65 and STAT3; and down-regulated mRNA levels of pro-inflammatory cytokines IL-6, IL-1beta and TNF-alpha that are transcriptionally regulated by NF-kappaB and STAT3 in the cell model. chrysoeriol 13-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 140-143 31999977-14 2020 In addition, chrysoeriol decreased the production of NO and prostaglandin E2; inhibited the phosphorylation of inhibitor of kappaB (Ser32), p65 (Ser536) and Janus kinase 2 (Tyr1007/1008); decreased nuclear localization of p50, p65 and STAT3; and down-regulated mRNA levels of pro-inflammatory cytokines IL-6, IL-1beta and TNF-alpha that are transcriptionally regulated by NF-kappaB and STAT3 in the cell model. chrysoeriol 13-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 227-230 31898581-12 2020 Translocation of nuclearfactor-kappa B (NF-kappaB) and upregulation of p-p65, TNF-alpha, IL-1beta were inhibited by l-CDL. corydalmine 116-121 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-76 31720988-8 2020 Curcumin administration also restored the redox balance and phosphorylation status of P65-NF-kappaB. Curcumin 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 86-99 32093310-10 2020 The binding of p65 on the promoter region of CLDN7 was increased by ANGII, which was inhibited by losartan and BAY in chromatin immunoprecipitation assay. Losartan 98-106 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 15-18 32084579-10 2020 Furthermore, ALA significantly inhibited the phosphorylation of IkappaBalpha and NF-kappaB (p65) activation in ALI. alpha-Linolenic Acid 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 92-95 31918291-12 2020 Immunohistochemical and immunofluorescence data demonstrated that, compared with the model group, blebbistatin intervention reduced expression of NMMHCIIA, TF, GSK3beta, p65, and p-p65 in carotid-artery endothelia in the CAL-induced AT model, but it increased levels of p-GSK3beta. blebbistatin 98-110 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 170-173 31802382-5 2020 The results of western blot analysis and electrophoretic mobility shift assays showed that ellipticine markedly suppressed LPS-induced activation of the JNK/AP-1 (c-Fos and c-Jun) signaling pathway, but not ERK/p38/NF-kappaB pathway (p65 and p50) activation. ellipticine 91-102 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 234-237 31863920-4 2020 Moreover, baicalein significantly inhibited reactive oxygen species (ROS) production, decreased cyclooxygenase-2 (COX-2) and nuclear factor-b (NF-kappaB)/p65 expression. baicalein 10-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 154-157 31863867-8 2020 OBB appreciably inhibited TLR4-MyD88-NF-kappaB signaling pathway through down-regulating the protein expressions of TLR4 and MyD88, inhibiting the phosphorylation of IkappaBalpha, and the translocation of NF-kappaB p65 from cytoplasm to nucleus. neooxyberberine 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 215-218 31874178-7 2020 When exposed to 5, 10, or 20 mug MC-LR/mL, expressions of proteins involved in inflammatory, p-65 and iNOS were significantly greater than those of the controls. cyanoginosin LR 33-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 93-97 32410853-7 2020 3,5- and 4,5-di-O-E-caffeoylquinic acids also inhibited phosphorylation of both p65 and p38 (P < 0.05). 3,5- and 4,5-di-o-e-caffeoylquinic acids 0-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 80-83 31577939-15 2020 Furthermore, loganin suppressed nuclear translocation of p65 protein, and decreased the amount of p-I-kappaB in chondrocytes. loganin 13-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 57-60 32038294-12 2019 Treatment of mice with ThG increased O-glycosylation of NF-kappaB p65 subunit in mesenteric arteries, which was associated with reduced Ser536 phosphorylation of NF-kappaB p65. seryl-seryl-seryl-arginine 136-139 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 31812773-11 2020 Finally, verteporfin exhibited an anti-inflammation effect by crosslinking of protein such as NF-kappaB p65, JAK1, JAK2, STAT1, or STAT3 leading to inflammation. verteporfin 9-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 104-107 31952106-5 2020 In this study, we aimed to apply our micelles to inhibit metastasis and evaluated the inhibitory effect of anti-RelA siRNA (siRelA), which is a subunit of NF-kappaB conjugated with MPEG-PCL-CH2R4H2C, via systemic administration. methoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-methoxy poly(ethylene glycol) 181-198 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 112-116 32021098-6 2020 Additionally, expression of PPAR-gamma-related genes was increased and phosphorylation of P38 MAPK, NF-kappaB p65 and JAK2/STAT1-related proteins was decreased in Bergenin pre-treatment groups in a dose-dependent manner. bergenin 163-171 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 110-113 32194780-7 2020 Western blot analysis revealed that curcumol reduced the translocation of p65 to the nucleus and decreased p-ERK. curcumol 36-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-77 31790652-0 2020 Dopamine attenuates lipopolysaccharide-induced expression of proinflammatory cytokines by inhibiting the nuclear translocation of NF-kappaB p65 through the formation of dopamine quinone in microglia. Dopamine 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 140-143 31898867-4 2020 Moreover, nuclear accumulation of p65 and transcription of NF-kB-regulated genes were suppressed in sevoflurane-administered mice, suggesting that sevoflurane inhibits the NF-kB signaling pathway. sevoflurane 100-111 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 34-37 31898867-4 2020 Moreover, nuclear accumulation of p65 and transcription of NF-kB-regulated genes were suppressed in sevoflurane-administered mice, suggesting that sevoflurane inhibits the NF-kB signaling pathway. sevoflurane 147-158 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 34-37 31790652-0 2020 Dopamine attenuates lipopolysaccharide-induced expression of proinflammatory cytokines by inhibiting the nuclear translocation of NF-kappaB p65 through the formation of dopamine quinone in microglia. Dopamine 169-177 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 140-143 31790652-0 2020 Dopamine attenuates lipopolysaccharide-induced expression of proinflammatory cytokines by inhibiting the nuclear translocation of NF-kappaB p65 through the formation of dopamine quinone in microglia. Quinones 178-185 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 140-143 31790652-8 2020 Western blot and immunocytochemical analyses revealed that dopamine inhibited LPS-induced nuclear translocation of nuclear factor-kappa B (NF-kappaB) p65. Dopamine 59-67 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 150-153 31790652-9 2020 Dopamine also attenuated the expression of cytokines and the nuclear translocation of NF-kappaB p65 induced by LPS in mouse microglial cells in primary culture. Dopamine 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-99 31790652-10 2020 These results suggest that dopamine attenuated LPS-induced expression of cytokines by inhibiting the nuclear translocation of NF-kappaB p65 through the formation of dopamine quinone in microglial cells. Dopamine 27-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-139 31790652-10 2020 These results suggest that dopamine attenuated LPS-induced expression of cytokines by inhibiting the nuclear translocation of NF-kappaB p65 through the formation of dopamine quinone in microglial cells. Dopamine 165-173 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-139 31790652-10 2020 These results suggest that dopamine attenuated LPS-induced expression of cytokines by inhibiting the nuclear translocation of NF-kappaB p65 through the formation of dopamine quinone in microglial cells. Quinones 174-181 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-139 31796384-4 2020 The further studies indicated that zileuton suppressed hippocampal neuroinflammation, evidenced by lower levels of TNF-alpha, IL-1beta and nuclear NF-kappaB p65 as well as decreased number of Iba1-positive cells. zileuton 35-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 157-160 31880261-7 2020 To further confirm the mechanism of propofol on OGD/R-induced inflammation in mouse N2A cells, P65 was over-expressed and the above experiments were repeated. Propofol 36-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-98 31206674-6 2020 We showed that 3-MA treatment decreases the number of eosinophils, eosinophil peroxidase (EPO) activity, goblet cells hyperplasia, proinflammatory cytokines, and nuclear factor kappa B (NFkappaB) p65 immunocontent in the lung. 3-methyladenine 15-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 196-199 31762195-8 2020 However, cotreatment with melatonin and an SIRT1 inhibitor reduced the level of inflammatory mediators compared with that by treatment with the SIRT1 inhibitor alone, which was accompanied by elevation in SIRT1 expression and reduction in p65 acetylation. Melatonin 26-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 239-242 31762195-5 2020 However, melatonin induced the enhancement of SIRT1 expression, which eventually decreased p65 acetylation in CSC-stimulated J774 cells. Melatonin 9-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-94 31797546-0 2020 Hic-5 deficiency protects cerulein-induced chronic pancreatitis via down-regulation of the NF-kappaB (p65)/IL-6 signalling pathway. Ceruletide 26-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-105 31762195-6 2020 Melatonin-treated mice exhibited an enhancement in SIRT1 expression with the reduction in p65 acetylation, which decreased the level of inflammatory mediators induced by CS. Melatonin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-93 31797546-8 2020 We also found that the Hic-5 up-regulation by cerulein activated the NF-kappaB (p65)/IL-6 signalling pathway and regulated the downstream extracellular matrix (ECM) genes such as alpha-SMA and Col1a1. Ceruletide 46-54 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 80-83 31797546-9 2020 Therefore, we determined whether suppressing NF-kappaB/p65 alleviated CP by treating mice with the NF-kappaB/p65 inhibitor triptolide in the cerulein-induced CP model and found that pancreatic fibrosis was alleviated by NF-kappaB/p65 inhibition. triptolide 123-133 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 31797546-9 2020 Therefore, we determined whether suppressing NF-kappaB/p65 alleviated CP by treating mice with the NF-kappaB/p65 inhibitor triptolide in the cerulein-induced CP model and found that pancreatic fibrosis was alleviated by NF-kappaB/p65 inhibition. triptolide 123-133 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-112 31797546-9 2020 Therefore, we determined whether suppressing NF-kappaB/p65 alleviated CP by treating mice with the NF-kappaB/p65 inhibitor triptolide in the cerulein-induced CP model and found that pancreatic fibrosis was alleviated by NF-kappaB/p65 inhibition. triptolide 123-133 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-112 31797546-9 2020 Therefore, we determined whether suppressing NF-kappaB/p65 alleviated CP by treating mice with the NF-kappaB/p65 inhibitor triptolide in the cerulein-induced CP model and found that pancreatic fibrosis was alleviated by NF-kappaB/p65 inhibition. Ceruletide 141-149 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 31746359-11 2020 In addition, BBR inhibited translocation of nuclear factor (NF)-kappaB p65 from the cytosol to the nucleus, and degradation of inhibitory kappa-Balpha in LPS-exposed mIMCD-3 cells. Berberine 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 71-74 31915509-9 2019 In addition, the phosphorylation level of AKT was markedly upregulated during oxidative stress to promote p65 nuclear translocation, triggering an inflammatory response that exacerbated cell damage and OA treatment significantly inhibited this process. Oleic Acids 202-204 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 106-109 31704270-8 2020 Whereas acute cocaine-treated mice showed transient increases in p-ERK1/2/ERK1/2 and p-p65/p65 NFkappaB ratios after cocaine injection, repeated cocaine-treated mice showed transient increases in p-ERK1/2/ERK1/2, p-p38/p38 MAPK, p-NFkappaB p65/NF-kappaB p65 and p-CREB/CREB ratios. Cocaine 14-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-103 31704270-8 2020 Whereas acute cocaine-treated mice showed transient increases in p-ERK1/2/ERK1/2 and p-p65/p65 NFkappaB ratios after cocaine injection, repeated cocaine-treated mice showed transient increases in p-ERK1/2/ERK1/2, p-p38/p38 MAPK, p-NFkappaB p65/NF-kappaB p65 and p-CREB/CREB ratios. Cocaine 14-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 87-90 31704270-8 2020 Whereas acute cocaine-treated mice showed transient increases in p-ERK1/2/ERK1/2 and p-p65/p65 NFkappaB ratios after cocaine injection, repeated cocaine-treated mice showed transient increases in p-ERK1/2/ERK1/2, p-p38/p38 MAPK, p-NFkappaB p65/NF-kappaB p65 and p-CREB/CREB ratios. Cocaine 14-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-94 31759089-8 2020 Moreover, GPS increased the TGR5 protein levels and promoted the interaction between IkappaBalpha and beta-arrestin2, thereby inhibiting the reduction of IkappaBalpha and blocked NF-kappaB p65 nuclear translocation in the kidneys of STZ-induced diabetic mice. gentiopicroside 10-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 189-192 31618665-12 2020 Mechanistically, p53 antagonist PFTalpha abolished TP-induced the inhibition of IKKbeta, IkappaBalpha phosphorylation, p65 nuclear translocation, and GLUT1, GLUT4 expression. pifithrin 32-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-122 31618665-12 2020 Mechanistically, p53 antagonist PFTalpha abolished TP-induced the inhibition of IKKbeta, IkappaBalpha phosphorylation, p65 nuclear translocation, and GLUT1, GLUT4 expression. triptolide 51-53 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-122 31849516-8 2019 Furthermore, NLRP3-inflammasome and p-p65/p65 were elevated after ALA-PDT mediated IL1beta production in cancer-associated-fibroblasts. delta-aminolevulinic acid methyl ester 66-69 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 38-41 31842455-9 2019 Transfection experiments using apoA-I promoter deletion mutants, chromatin immunoprecipitation, and protein-DNA interaction assays demonstrated that treatment of hepatocytes with BPA induced NF-kappaB signaling and thus the recruitment of p65/50 proteins to the multiple NF-kappaB binding sites located in the apoA-I promoter. bisphenol A 179-182 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 239-242 31849516-8 2019 Furthermore, NLRP3-inflammasome and p-p65/p65 were elevated after ALA-PDT mediated IL1beta production in cancer-associated-fibroblasts. delta-aminolevulinic acid methyl ester 66-69 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 42-45 32042747-11 2019 Results: In vitro, we observed that GENT reduced the inflammatory cytokine production of BMMs stimulated by (LPS)/IFN-gamma and ameliorated the phosphorylation of IKKalpha/beta and p65, the degradation of IkappaBalpha, and the translocation of p65 into the nucleus. gentiopicroside 36-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 181-184 31849652-8 2019 Western blot analysis revealed that Sal inhibited p65 and p38 activation together with peroxisome proliferator-activated receptor (PPARgamma) up-regulation. rhodioloside 36-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 50-53 32042747-8 2019 Moreover, NF-kappaB inhibitor and p65-targeted siRNAs were further used to validate the anti-inflammatory mechanism of GENT. gentiopicroside 119-123 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 34-37 32042747-11 2019 Results: In vitro, we observed that GENT reduced the inflammatory cytokine production of BMMs stimulated by (LPS)/IFN-gamma and ameliorated the phosphorylation of IKKalpha/beta and p65, the degradation of IkappaBalpha, and the translocation of p65 into the nucleus. gentiopicroside 36-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 244-247 32042747-13 2019 NF-kappaB inhibitor and p65 siRNAs eliminated the inhibition effect of GENT. gentiopicroside 71-75 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 24-27 31545206-8 2019 Furthermore, exposure to TBBPA significantly elevated the protein levels of phosphorylated NF-kappaB p65 (p-p65), while it reduced LPS-stimulated p-p65 protein levels. tetrabromobisphenol A 25-30 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 31571510-7 2019 Furthermore, taraxasterol dramatically down-regulated the expressions of T toll-like receptor (TLR2), TLR4 and nuclear factor-kappaappaB (NF-kappaB) p65, and decreased the expression ratio of Bax/Bc1-2 in hepatic tissues. taraxasterol 13-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 149-152 31409917-11 2019 These data suggest that augmented O-GlcNAcylation mitigates IH-induced cardiac remodeling by suppressing NFAT and NF-kappaB activities through the O-GlcNAcylation of GSK-3beta and NF-kappaB p65. Ile-His 60-62 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 190-193 31798708-8 2019 Signaling pathway analysis further demonstrated that OV treatment did not affect the expression of TLR2 and p65 but suppressed p65 phosphorylation. vanillin 53-55 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 127-130 31661121-8 2019 Furthermore, DHA reduced the LPS-induced inflammatory response by suppressing the degradation of I-kappaB and the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB)/p65 in vivo and in vitro. artenimol 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 214-217 31677497-6 2019 In addition, EP decreased microglia enrichment in myelin sheath, and declined TLR4/p-NF-kb/p65 and IL-1beta and IL-6, inhibiting microglia-mediated neuroinflammation. ethyl pyruvate 13-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-94 31638199-8 2019 LY294002 further enhanced Ang II-induced downregulation of Akt and p65 NF-kappaB activation, as well as upregulation of caspase-9 mRNA and protein, and promoted the apoptosis of podocytes. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 67-80 31950023-12 2019 DHA reduced expression of PKC-delta and NF-kappaB p65 in pancreatic tissues of cerulein-treated mice. Docosahexaenoic Acids 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 50-53 31950023-12 2019 DHA reduced expression of PKC-delta and NF-kappaB p65 in pancreatic tissues of cerulein-treated mice. Ceruletide 79-87 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 50-53 31638199-9 2019 Of note, 740Y-P restored Ang II-induced downregulation of Akt and p65 NF-kappaB activation, and upregulation of caspase-9, and decreased podocyte apoptosis. 740y-p 9-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-79 31827674-8 2019 Moreover, aloin inhibited hepatocyte apoptosis and inflammatory response that was caused by the upregulated expression of Bcl-2, the downregulated expression of cleaved caspase3(C-caspase3), Bax, Toll-like receptor 4 (TLR4), FADD, MyD88, TRAF6, phosphorylated IKKalpha/beta (p-IKKalpha/beta), and phosphorylated nuclear factor kappaB p65 (p-NF-kappaB p65). alloin 10-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 334-337 31849616-8 2019 Both inhibitors blunted LPA-induced phosphorylation of STAT1 and STAT3, p65, and c-Jun and consequently reduced the secretion of pro-inflammatory cyto-/chemokines (IL-6, TNFalpha, IL-1beta, CXCL10, CXCL2, and CCL5) at non-toxic concentrations. lysophosphatidic acid 24-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 31827674-8 2019 Moreover, aloin inhibited hepatocyte apoptosis and inflammatory response that was caused by the upregulated expression of Bcl-2, the downregulated expression of cleaved caspase3(C-caspase3), Bax, Toll-like receptor 4 (TLR4), FADD, MyD88, TRAF6, phosphorylated IKKalpha/beta (p-IKKalpha/beta), and phosphorylated nuclear factor kappaB p65 (p-NF-kappaB p65). alloin 10-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 351-354 31827682-6 2019 DBA also upregulated the protein levels of Toll-like receptor (TLR) 4, myeloid differentiation factor 88 (MyD88), tumor necrosis factor receptor-associated factor 6 (TRAF6), inhibitor of nuclear factor kappaB alpha (IkappaB-alpha), nuclear factor kappaB p65 (NF-kappaB p65), and the phosphoralation of P38 mitogen-activated protein kinase (P38MAPK) and c-Jun N-terminal kinase (JNK). dibromoacetic acid 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 254-257 31827682-6 2019 DBA also upregulated the protein levels of Toll-like receptor (TLR) 4, myeloid differentiation factor 88 (MyD88), tumor necrosis factor receptor-associated factor 6 (TRAF6), inhibitor of nuclear factor kappaB alpha (IkappaB-alpha), nuclear factor kappaB p65 (NF-kappaB p65), and the phosphoralation of P38 mitogen-activated protein kinase (P38MAPK) and c-Jun N-terminal kinase (JNK). dibromoacetic acid 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 269-272 31610190-9 2019 Additionally, VGX-1027 treatment resulted in a substantial decrease in IL-1beta, IL-6, TNF-alpha, IFN-gamma, and NF-kappaB p65 production, but increased IL-10 production in CD4+ T cells. 3-phenyl-4,5-dihydro-5-isoxazole acetic acid 14-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 123-126 31788011-11 2019 Curcumin also markedly down-regulated the protein expression of hepatic TLR4 and myeloid differentiation factor 88 (MyD88), inhibited p65 nuclear translocation and DNA binding activity of nuclear factor-kappaB (NF-kappaB) in the liver. Curcumin 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 134-137 31730008-15 2019 In cultured microglia, synaptamide increased cAMP and inhibited LPS-induced proinflammatory cytokine expression by inhibiting the translocation of NF-kappaB subunit RelA into the nucleus. Docosahexaenoyl Ethanolamide 23-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 165-169 31798539-5 2019 RT-PCR and ELISA were used to detect the inflammatory factors, and immunofluorescence was applied to examine the phospho-nuclear factor (NF)-kappaB p65/p100 and Ki67-positive cells in the colons. phosphorylleucylphenylalanine 113-120 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 148-151 31781591-9 2019 Moreover, DSS-induced elevation of phosphorylation of PI3K, AKT, IKKalpha, IkappaBalpha, and NF-kappaB (p65) was remarkably blunted by dihydroartemisinin both in vivo and in vitro, indicating an inhibitive property on the PI3K/AKT and NF-kappaB signaling pathways. artenimol 135-153 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 104-107 31519697-7 2019 Knockdown of both p65 and c-Jun completely blocked the effect of DEX on Urat1, suggesting that GR regulates Urat1 via its interaction with both nuclear factor kappa B (NF-kB) and activator protein 1 (AP-1) signaling pathways. Dexamethasone 65-68 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 18-21 31446053-8 2019 TCE treatment also modulated Nrf2 pathway with decreased Nrf2 and HO-1, and elevated NF-kappaB (p65) expression in the liver. Trichloroethylene 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-99 31626263-6 2019 Furthermore, PTE reversed the phosphorylation of ConA-induced intrahepatic inflammatory kinases including JNK, ERK1/2, p38 and p65. pterostilbene 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 127-130 31680772-2 2019 The previous studies have revealed that RA had therapeutic effects on hepatocellular carcinoma (HCC) in the H22-xenograft models by inhibiting the inflammatory cytokines and NF-kappaB p65 pathway in the tumor microenvironment. rosmarinic acid 40-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 184-187 31580526-6 2019 We observed that a downstream kinase of p38 MAP kinase, MSK1, was activated by Ras (G12V) and catalyzed the phosphorylation of p65/RelA at Ser-276, which is critical for its transcriptional activation. Serine 139-142 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 127-130 31596631-0 2019 Ethanol Extract of Ligularia fischeri Inhibits the Lipopolysaccharide-Induced Inflammatory Response by Exerting Anti-Histone Acetyltransferase Activity to Negatively Regulate p65. Ethanol 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 175-178 31596631-6 2019 Interestingly, we found that ELF blocked p65 translocation in LPS-stimulated Raw 264.7 cells by attenuating acetylation at lysine residue 310 of p65. Lysine 123-129 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 41-44 31596631-6 2019 Interestingly, we found that ELF blocked p65 translocation in LPS-stimulated Raw 264.7 cells by attenuating acetylation at lysine residue 310 of p65. Lysine 123-129 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 145-148 31580526-6 2019 We observed that a downstream kinase of p38 MAP kinase, MSK1, was activated by Ras (G12V) and catalyzed the phosphorylation of p65/RelA at Ser-276, which is critical for its transcriptional activation. Serine 139-142 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 131-135 31749798-5 2019 Phenotypic and transcriptomic analyses showed that RelA is critical in the acquisition of the effector Treg state independently of surrounding inflammatory environment. treg 103-107 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-55 31749798-6 2019 Unexpectedly, RelA-deficient Tregs also displayed reduced stability and cells that had lost Foxp3 produced inflammatory cytokines. tregs 29-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 14-18 31749798-7 2019 Overall, we show that RelA is critical for Treg biology as it promotes both the generation of their effector phenotype and the maintenance of their identity. treg 43-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 22-26 31615487-9 2019 In mechanism, we found that CSO decreased the expression of MuRF1 and the ratio of phospho-p65 (Ser536) to p65 in muscle tissue. seryl-seryl-seryl-arginine 96-102 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-94 31323300-0 2019 beta-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transition. beta-carboline alkaloids 0-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 105-108 31323300-0 2019 beta-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transition. Bleomycin 35-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 105-108 31323300-10 2019 A total of 12 beta-carboline alkaloids were identified in Part1 and they all showed suppressive effect on inflammatory cytokines including MCP-1, TNF-alpha, IL-6 and IL-1beta through inhibition of NF-kb/p65 phosphorylation, and that epithelial-mesenchymal transition (EMT) process was reversed by different compounds in different levels. beta-carboline alkaloids 14-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 203-206 31323300-12 2019 CONCLUSIONS: This study showed that antifibrogenic effect of beta-carboline alkaloids was due to inhibiting the initial of inflammation through NF-kb/p65 pathway and reversing the process of EMT. beta-carboline alkaloids 61-85 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 150-153 31451221-16 2019 Additionally, germacrone remarkably enhanced IkappaB expression, but suppressed p-p65 level in CIA mice. germacrone 14-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 30632647-9 2019 In addition, GEN-27 treatment significantly suppressed LPS-induced phosphorylation of nuclear factor-kappaB (NF-kappaB) p65 and alleviated LPS-induced increase of transcriptional activity of NF-kappaB in RAW264.7 cells. gen-27 13-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 120-123 31636619-10 2019 The underlying mechanism of TSA on eosinophilic meningitis might be associated with decreased NF-kappaB p65 nuclear accumulation by inhibiting IkappaB phosphorylation. trichostatin A 28-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 104-107 31636619-12 2019 We identified the correlations in the gene expression of NF-kappaB p65 with Lrp10, Il12rb1, Nfkbia, Ube2n, and Ube2d1 in infected mice after TSA administration. trichostatin A 141-144 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 67-70 31632276-8 2019 Phosphorylated NF-kappaB p65 at serine 276, a marker of NF-kappaB activation, was markedly induced by MWCNTs in the nucleus of fibroblastic cells. cholecystokinin C-terminal flanking peptide 32-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 25-28 31933758-6 2019 In addition, treatment with apigenin down-regulated the expression of nuclear factor kappa-light -chain-enhancer of activated B cells (NF-kappaB) p65 submit in lung tissue of asthmatic mice. Apigenin 28-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 146-149 31306981-6 2019 Western blotting was performed to revealed that glycitin inhibited the activation of NF-kappaB and MAPKs signaling pathways by suppressing the expression of TLR4 protein and the phosphorylation of IKKbeta, IkappaBalpha, p65, p38, ERK, and JNK. glycitin 48-56 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 220-223 30940905-6 2019 Furthermore, we found that both pharmacological and genetic perturbation of ATM and p65 significantly decreased the residual ALL cells after Ara-C treatment in ALL xenograft mouse models. Cytarabine 141-146 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 31616301-8 2019 Moreover, MH dramatically suppressed the inhibitor of kappa B alpha (IkappaBalpha) degradation and subsequent nuclear factor-kappa B (NF-kappaB) p65 translocation into the nucleus and NF-kappaB-mediated cytokines, such as tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6. morin 10-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 145-148 31399520-4 2019 Tyrosine-phosphorylated PARP1 is required for protein poly(ADP-ribosyl)ation of RelA/p65 and NF-kappaB-dependent expression of proinflammatory genes in murine RAW 264.7 macrophages, human monocytic THP1 cells, or mouse lungs. Tyrosine 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 80-84 31545785-14 2019 In H9C2 cardiomyocytes, the p65-specific inhibitor BAY11-7082 exerted similar effects as As-IV. 3-(4-methylphenylsulfonyl)-2-propenenitrile 51-61 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 28-31 31399520-4 2019 Tyrosine-phosphorylated PARP1 is required for protein poly(ADP-ribosyl)ation of RelA/p65 and NF-kappaB-dependent expression of proinflammatory genes in murine RAW 264.7 macrophages, human monocytic THP1 cells, or mouse lungs. Tyrosine 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 85-88 31313354-11 2019 It was concluded that SA has a potential to limit inflammation via inhibiting the p65-NF-kappaB and STAT3 signaling; hence it can be used for therapeutic purposes. syringic acid 22-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-95 31431007-5 2019 The inhibition of d-galactose-induced oxidative damage in the liver was correlated with the torularhodin-mediated effects on improving the activity of Nrf2/HO-1, reducing the expression of Bax and NF-kappaB p65 by western blot analysis. Galactose 18-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 207-210 31431007-5 2019 The inhibition of d-galactose-induced oxidative damage in the liver was correlated with the torularhodin-mediated effects on improving the activity of Nrf2/HO-1, reducing the expression of Bax and NF-kappaB p65 by western blot analysis. torularhodin 92-104 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 207-210 31233346-7 2019 Western blotting analysis showed that CUMS markedly suppressed the levels of phosphorylated GSK-3beta (Ser9) and phosphorylated Akt (Ser473) but significantly enhanced the translocation of NF-kappaB p65 from cytosol to nuclei in the hippocampus and cerebral cortex of the mice. cums 38-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 199-202 31151047-3 2019 Increased protein expression of TNFR1 and NFkappaB p65 was detected in the left ventricle (LV) of WT mice chronically treated with ethanol. Ethanol 131-138 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 30878677-6 2019 Additionally, compared with the control group, cis-khellactone significantly decreased the activation of NF-kappaB p65 in these infiltrated macrophages. (+)-cis-Khellactone 47-62 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 115-118 31069623-9 2019 Moreover, in MPP+-treated BV-2 cells and primary microglia, FTY720 treatment significantly attenuated the increases in the phosphorylation of PI3K/AKT/GSK-3beta, reduced ROS generation and p65 activation, and also inhibited the activation of NLRP3 inflammasome and caspase-1. mangion-purified polysaccharide (Candida albicans) 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 189-192 31069623-9 2019 Moreover, in MPP+-treated BV-2 cells and primary microglia, FTY720 treatment significantly attenuated the increases in the phosphorylation of PI3K/AKT/GSK-3beta, reduced ROS generation and p65 activation, and also inhibited the activation of NLRP3 inflammasome and caspase-1. Fingolimod Hydrochloride 60-66 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 189-192 31069623-12 2019 Graphical Abstract FTY720 may reduce ROS production by inhibiting the PI3K/AKT/GSK-3beta signaling pathway, while at the same time reducing p65 phosphorylation, thus decreasing NLRP3 inflammasome activation through these two pathways, ultimately reducing microglia activation-induced neuronal damage. Fingolimod Hydrochloride 19-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 140-143 31480279-5 2019 These effects were mediated by the acetylation of lysine 9 of histone 3 and lysine 310 of p65, which resulted in increased mitogen-activated protein kinase phosphorylation, nuclear translocation of p65, microglia activation, and acetylation of high-mobility group box 1. Lysine 76-82 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 198-201 31227976-14 2019 MiR-19b-3p mimic and GRK6 siRNA showed comparable inhibitory effect on IL-1beta-provoked NF-kappaB as reflected by the expression of p-p65. mir-19b-3p 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 135-138 31480279-5 2019 These effects were mediated by the acetylation of lysine 9 of histone 3 and lysine 310 of p65, which resulted in increased mitogen-activated protein kinase phosphorylation, nuclear translocation of p65, microglia activation, and acetylation of high-mobility group box 1. Lysine 50-56 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-93 31480279-5 2019 These effects were mediated by the acetylation of lysine 9 of histone 3 and lysine 310 of p65, which resulted in increased mitogen-activated protein kinase phosphorylation, nuclear translocation of p65, microglia activation, and acetylation of high-mobility group box 1. Lysine 50-56 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 198-201 31695328-16 2019 100 mg/kg silibinin markedly reduced collagen I, fibronectin, and p-p65 expressions in mice renal tissues. Silybin 10-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 31480279-5 2019 These effects were mediated by the acetylation of lysine 9 of histone 3 and lysine 310 of p65, which resulted in increased mitogen-activated protein kinase phosphorylation, nuclear translocation of p65, microglia activation, and acetylation of high-mobility group box 1. Lysine 76-82 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-93 31382637-8 2019 The anti-inflammatory effects of MMI-0100 on DSS-induced colitis were achieved by down-regulating the phosphorylation level of MK2, IkappaBalpha and p65 protein. dss 45-48 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 149-152 31195152-3 2019 We report a systems-level pharmacoproteomics in a standardized murine model of toll-like receptor TLR3-NFkappaB/RelA innate inflammation in the absence or presence of a highly selective BRD4 inhibitor (ZL0454) or nonselective bromodomain and extraterminal domain inhibitor (JQ1). CHEMBL4159382 202-208 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 112-116 31162673-9 2019 EtOH + LPS treatment increased hepatic inflammation, as shown by the increased hepatic protein levels of Toll-like receptor-4, p65, and p-IkappaB, and increased oxidative stress, as shown by protein carbonyl levels and reactive oxygen species formation, which were reduced by L6H21 treatment. Ethanol 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 127-130 30728466-12 2019 Furthermore, the olfactory bulbs in MPTP/P-treated mice showed significantly increased levels of interleukin-1beta (IL-1beta), caspase-1, glial fibrillary acidic protein (GFAP), Toll receptor 4 (TLR4), phosphorylation of p65, as well as activated molecules of NOD-like receptor protein 3 (NLRP3) that were associated with neuroinflammation. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 36-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 221-224 30728466-12 2019 Furthermore, the olfactory bulbs in MPTP/P-treated mice showed significantly increased levels of interleukin-1beta (IL-1beta), caspase-1, glial fibrillary acidic protein (GFAP), Toll receptor 4 (TLR4), phosphorylation of p65, as well as activated molecules of NOD-like receptor protein 3 (NLRP3) that were associated with neuroinflammation. Phosphorus 37-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 221-224 31017817-7 2019 In cultured ECs, narciclasine inhibited the expression of cell adhesion molecules intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin and blocked crucial steps of the NF-kappaB activation cascade: NF-kappaB promotor activity, p65 nuclear translocation, inhibitor of kappaB alpha (IkappaBalpha) phosphorylation and degradation, and IkappaBalpha kinase beta and TGF-beta-activated kinase 1 phosphorylation. narciclasine 17-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 259-262 31203114-0 2019 PIM1 inhibitor SMI-4a attenuated lipopolysaccharide-induced acute lung injury through suppressing macrophage inflammatory responses via modulating p65 phosphorylation. SMI-4a 15-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 147-150 31034776-6 2019 DSS-treated AQP4-/- mice also had lower immunostaining of NF-kappaB p65 as well as nuclear levels of p65 and phosphorylated p65. Dextran Sulfate 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 31034776-6 2019 DSS-treated AQP4-/- mice also had lower immunostaining of NF-kappaB p65 as well as nuclear levels of p65 and phosphorylated p65. Dextran Sulfate 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 30937840-8 2019 The increased protein levels of p65 induced by LPS in the cytoplasm and nucleus were both decreased by tizoxanide, and the nuclear translocation of p65 was also restrained in cell imaging. tizoxanide 103-113 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 32-35 30854667-7 2019 Further studies indicated that rhoifolin inhibited p65 translocation to the nucleus and the activity of NFATc1 and NF-kappaB rhoifolin could decrease the number of tartrate-resistant acid phosphate-positive osteoclasts and titanium particle-induced C57 mouse calvarial bone loss in vivo. rhoifolin 31-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 30854697-10 2019 In histopathological observations, TFPPL-treated mice exhibited reduced hepatocellular Hsp90, TNF-alpha, nuclear factor kappa-light-chain-enhancer of activated B cells-p65 positive cells, and lowered Bax and caspase-3-labeled cells in the livers. tfppl 35-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 168-171 30825206-9 2019 Moreover, NAC blocked cholesterol-induced phosphorylation of IkappaBalpha and p65. Acetylcysteine 10-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 78-81 30825206-9 2019 Moreover, NAC blocked cholesterol-induced phosphorylation of IkappaBalpha and p65. Cholesterol 22-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 78-81 31396089-9 2019 Ad libitum HRW consumption also had an inhibitory effect on the METH-induced increase in the expression of Bax/Bcl-2, cleaved caspase-3, glucose-related protein 78 (GRP 78), CCAAT/enhancer-binding protein homologous protein (CHOP), and p-NF-kB p65 expression and elevation of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha levels in the hippocampus. Methamphetamine 64-68 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 244-247 30953351-7 2019 Meanwhile, CTPR9 markedly reduced the expression of toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), and NF-kappaB p65 phosphorylation by promoting AMPK phosphorylation in vivo and in vitro. ctpr9 11-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 138-141 31075241-7 2019 It was also observed that stevioside significantly suppressed NF-kappaB (p65) activation by abrogating IkappaB phosphorylation and attenuated the phosphorylation of p38, ERK and JNK proteins in colon tissues. stevioside 26-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-76 31210194-7 2019 Furthermore, cinnamaldehyde reduced matrix metalloproteinase-2 (MMP-2) expression and attenuated the high phosphorylation level of IkappaBalpha and p65 NF-kappaB. cinnamaldehyde 13-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 148-161 31270147-6 2019 Treatment of 16HBE cells and Balb/c mice with ergosterol inhibited CSE-induced inflammatory and oxidative stress and apoptosis by inhibiting the activation of NF-kappaB/p65. Ergosterol 46-56 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 169-172 31075241-8 2019 The findings of the present study suggest that stevioside exhibits anti-inflammatory property by inhibiting NF-kappaB (p65) and MAPK pathways and can be employed as an adjunct in nutraceuticals to treat IBD. stevioside 47-57 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-122 31270147-7 2019 Ergosterol suppressed apoptosis by inhibiting the expression of the apoptosis-related proteins both in vitro and in vivo Moreover, the usage of QNZ (an inhibitor of NF-kappaB) also partly demonstrated that NF-kappaB/p65 pathway was involved in the ergosterol protective progress. Ergosterol 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 216-219 31270147-8 2019 These results show that ergosterol suppressed COPD inflammatory and oxidative stress and apoptosis through the NF-kappaB/p65 pathway, suggesting that ergosterol may be partially responsible for the therapeutic effects of cultured C. sinensis on COPD patients. Ergosterol 24-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-124 30943581-7 2019 Plaque macrophages positive for nuclear p65 (RelA) NF-kappaB subunit were markedly reduced after K-80003 treatment. K-80003 97-104 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-43 30951719-6 2019 Finally, CT-133 significantly blocked the LPS-induced P65 activation in both RAW264.7 macrophages and mouse lungs. ct-133 9-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 54-57 31262893-6 2019 RESULTS: Amentoflavone significantly inhibits tumor growth and reduces protein levels of phospho-extracellular signal-regulated kinase (P-ERK), nuclear factor-kappaB (NF-kappaB) p65 (Ser536), vascular endothelial growth factor (VEGF), matrix metallopeptidase 9 (MMP-9), X-linked inhibitor of apoptosis protein (XIAP), and cyclin-D1 in osteosarcoma in vivo. amentoflavone 9-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 178-181 30943581-7 2019 Plaque macrophages positive for nuclear p65 (RelA) NF-kappaB subunit were markedly reduced after K-80003 treatment. K-80003 97-104 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 45-49 30943581-8 2019 Also, K-80003 treatment inhibited 7-KC-induced p65 nuclear translocation, IkappaBalpha degradation, and transcription of NF-kappaB target genes. K-80003 6-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 47-50 30952064-0 2019 Extracellular ATP activates P2X7R-NF-kappaB (p65) pathway to promote the maturation of bone marrow-derived dendritic cells of mice. Adenosine Triphosphate 14-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 45-48 30952064-10 2019 Our study suggested that extracellular ATP could promote DC maturation and release of inflammatory cytokines through the binding of P2X7R and NF-kappaB (p65). Adenosine Triphosphate 39-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 153-156 31059066-6 2019 TQ-5 significantly reversed the LPS-induced degradation of inhibitor of NF-kappaBalpha and phosphorylation of p65. tq-5 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 110-113 31358372-7 2019 Jaceosidin could significantly decrease the levels of myeloperoxidase (MPO), cyclooxygenase-2 (COX-2) and nuclear factor-kappaB (NF-kappaB), COX-2 mRNA and NF-kappaB p65 mRNA together with increasing the activity of catalase (CAT). jaceosidin 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 166-169 30964965-4 2019 Additionally, olaparib blunted the protein expression of STAT-6 and GATA-3 considerably along with a modest reduction in p65-NF-kappaB phosphorylation. olaparib 14-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-134 31358372-8 2019 Additionally, Jaceosidin attenuated lung histopathological changes, inhibited the expressions of COX-2 and NF-kappaB p65 and reduced complement deposition with decreasing the levels of complement 3 (C3) and complement 3c (C3c) in serum. jaceosidin 14-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-120 31048100-6 2019 Furthermore, we elucidate that IKKalpha/beta-NF-kappaB p65 signaling pathway and phosphorylation of serine 534 in NF-kappaB p65 are required for the maximal expression of MCP-1. Serine 100-106 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 124-127 31267840-6 2019 Furthermore, it reduced the expression of p65-NF-kappaB and acetylation of histone H3 at lysine K14, K56 and K79 residues. Lysine 89-95 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 42-55 31338007-4 2019 DON also upregulated IL-1beta expression from between 0.5 h and 6 h after treatment, and enhanced the nuclear localization of the NF-kappaB subunits, p50 and p65. deoxynivalenol 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 158-161 31304904-11 2019 Naringin pretreatment of cells significantly inhibited the activation of p65/NF-kappaB in a concentration-dependent manner. naringin 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-76 31304904-12 2019 In BV2 microglia, naringin inhibits LPO-induced production of NO and inflammatory factors, through a mechanism involving inhibition of activation of the p65/NF-kappaB signaling pathway. naringin 18-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 153-156 30914368-7 2019 BF-I treatment led to the phosphorylation of MAPKs, NF-kappaB, and c-Jun (major component of AP-1 transcription factor) and induced the nuclear translocation of p65 in RAW264.7 cells. bf-i 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 161-164 31312498-8 2019 At the molecular level, PIC suppressed the phosphorylation of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK1/2), NF-kappaB p65, IkappaBalpha and AKT. 3,3',4,5'-tetrahydroxystilbene 24-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 151-154 30893559-3 2019 Mechanistically, 4-IPP inhibited RANKL-induced p65 phosphorylation and nuclear translocation by preventing the interaction of MIF with thioredoxin-interacting protein-p65 complexes. 4-iodo-6-phenylpyrimidine 17-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 47-50 31093481-6 2019 ASIB treatment caused a significant decrease in the glaucoma-induced up-regulation of NF-kappaB p65 activation. asib 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-99 31093481-7 2019 The phosphorylation of NF-kappaB p65 was almost completely inhibited in the glaucoma mice on treatment with 15 mg/kg dose of ASIB. asib 125-129 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-36 30893559-3 2019 Mechanistically, 4-IPP inhibited RANKL-induced p65 phosphorylation and nuclear translocation by preventing the interaction of MIF with thioredoxin-interacting protein-p65 complexes. 4-iodo-6-phenylpyrimidine 17-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 167-170 30893559-5 2019 In contrast, 4-IPP potentiated osteoblast differentiation and mineralization also through the inhibition of the p65/NF-kappaB signaling cascade. 4-iodo-6-phenylpyrimidine 13-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 112-115 30536812-6 2019 Propofol inhibited CFA-induced expression of p-extracellular signal-regulated kinase1/2 (p-ERK1/2) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) p65, as demonstrated by Western blot analysis. Propofol 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 178-181 30894684-10 2019 Depleting cytosolic mtDNA using DNase I or blocking TLR9 pathway by TLR9 antagonist, siRNA for TLR9 or p65 in HCC cells with Drp1 overexpression significantly decreased the recruitment and polarization of TAMs. tams 205-209 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 103-106 31360692-12 2019 Baicalein suppressed the phosphorylation and nuclear translocation of p65, resulting in a reduced DNA binding activity of NF-kappaB. baicalein 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 30847938-0 2019 Mangiferin attenuates bleomycin-induced pulmonary fibrosis in mice through inhibiting TLR4/p65 and TGF-beta1/Smad2/3 pathway. Bleomycin 22-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-94 30951781-9 2019 Additional investigations showed that 4-MCH significantly inhibited the phosphorylation of p65. 4-mch 38-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-94 30099700-10 2019 Finally, we used immunohistochemistry to demonstrate that TLR4 deficiency attenuated increased expression of MyD88 and NF-kB p65 after CIH treatment. cih 135-138 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 125-128 30951781-10 2019 Collectively, these results indicate that 4-MCH alleviated the inflammatory reaction through PPAR-gamma activation via the NF-kappaB-p65 signaling pathway, which regulates the expression of IL-6 and TNF-alpha in AH. 4-mch 42-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 133-136 31217746-7 2019 To determine whether the nuclear factor-kappa B (NF-kappaB) p65 pathway mediates the effect of thyroxine on Mo differentiation and myocardial cell apoptosis, the specific NF-kappaB p65 pathway inhibitor JSH-23 was administered to mice that underwent a thyroidectomy. Thyroxine 95-104 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 60-63 30940720-5 2019 In vitro experiments further revealed that TSH activated MAPKs (ERK1/2, p38alpha, and JNK) and IkappaB/p65 pathways in macrophages and increased inflammatory cytokine production and their recruitment of monocytes. Thyrotropin 43-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 103-106 30793522-4 2019 Stimulation of NOD2 by muramyl dipeptide (MDP) in BV2 cells induced the activation of NF-kappaB by the phosphorylation of p65 subunit and the degradation of IkappaBalpha. Acetylmuramyl-Alanyl-Isoglutamine 23-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-125 30878874-22 2019 The western blot results showed that osthole reduced the expression of NF-kappaB p65 and p-IkappaB alpha and increased the content of IkappaB alpha in colon tissues. osthol 37-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 81-84 30848526-7 2019 Moreover, in lipopolysaccharides-induced BV-2 cells, the levels of inflammatory factors (IL-1beta), p65 acetylation at lysine 310, and SIRT1 expression were different in the group treated with both baicalin and nicotinamide compared with the group treated with baicalin, which suggests that baicalin regulates SIRT1 and thereby inhibits p65 acetylation. baicalin 198-206 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 100-103 30848526-7 2019 Moreover, in lipopolysaccharides-induced BV-2 cells, the levels of inflammatory factors (IL-1beta), p65 acetylation at lysine 310, and SIRT1 expression were different in the group treated with both baicalin and nicotinamide compared with the group treated with baicalin, which suggests that baicalin regulates SIRT1 and thereby inhibits p65 acetylation. baicalin 198-206 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 337-340 31275508-7 2019 Cotreatment of macrophages with auranofin blocked the RANKL-induced inhibitors of kappaB kinase (IKK) phosphorylation, resulting in inhibition of nuclear translocation of p65. Auranofin 32-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 171-174 31105857-7 2019 In vivo and in vitro experiments, the expression of p65 and IkappaB kinase alpha was decreased and the expression of inhibitor of NF-kappaB was increased in the intervertebral disc tissue or nucleus pulposus cells of the vitamin D treatment group, indicating that vitamin D could suppress the NF-kappaB pathway. Vitamin D 221-230 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 52-55 30926424-7 2019 Mechanistically, TGF-beta1 induces phosphorylation of p65, i.e., activation of NF-kappaB, thereby promoting mRNA transcription and protein expression of MAT2A and reduces S-adenosylmethionine (SAM) concentration in HSCs. S-Adenosylmethionine 173-191 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 54-57 30716318-8 2019 In addition, immunohistochemistry staining and western blot analysis indicated that harmine treatment suppressed the expression of toll-like receptor 4 (TLR4) and the phosphorylation of nuclear factor-kappa B (NF-kappaB) p65 and inhibitor of kappaBalpha (IkappaBalpha) while inhibiting the expression of NLRP3, caspase-1 and interleukin-1beta (IL-1beta). Harmine 84-91 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 221-224 30682334-7 2019 Furthermore, CI-994 suppressed the phosphorylation of IkappaBalpha and p65 and the expression of downstream c-Fos and NFATc1. tacedinaline 13-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 71-74 31081070-11 2019 At the same time, the overexpression of miR-940 markedly decreased the protein levels of TLR4, P65, and iNOS in SCI mice. mir-940 40-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-98 30756213-10 2019 The phosphorylated p65 level in the nucleus was dramatically reduced in fisetin-treated mice compared to it in untreated mice. fisetin 72-79 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 19-22 30506106-7 2019 Furthermore, BCI treatment inhibited phosphorylation of P65 and nuclear P65 expression in LPS-activated macrophages. (E)-2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 56-59 31057653-7 2019 Expression of nuclear factor- (NF-) kappaB p65 was significantly decreased and phosphorylation of extracellular signal-regulated kinase (Erk), c-Jun NH2-terminal kinase (JNK), and PI3K/Akt by GBH, but not p38 MAPK, was decreased. gbh 192-195 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 43-46 30586589-0 2019 Astragalus polysaccharide from Astragalus Melittin ameliorates inflammation via suppressing the activation of TLR-4/NF-kappaB p65 signal pathway and protects mice from CVB3-induced virus myocarditis. Polysaccharides 11-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 126-129 30506106-7 2019 Furthermore, BCI treatment inhibited phosphorylation of P65 and nuclear P65 expression in LPS-activated macrophages. (E)-2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 30734183-7 2019 In vivo experiments also showed that high-dose PQ promotes inflammatory cytokines secretion, lung fibrosis and cell apoptosis, inhibits cell proliferation in mice models by regulating Keap1/p65/Nrf2 signal pathway. Paraquat 47-49 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 190-193 30734183-0 2019 High-Dose Paraquat Induces Human Bronchial 16HBE Cell Death and Aggravates Acute Lung Intoxication in Mice by Regulating Keap1/p65/Nrf2 Signal Pathway. Paraquat 10-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 127-130 30734183-8 2019 Therefore, we concluded that high-dose PQ (500 muM) inhibits 16HBE cell proliferation and autophagy, promotes cell death and mice lung fibrosis by regulating Keap1/p65/Nrf2 signal pathway. Paraquat 39-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 164-167 30862773-11 2019 Moreover, the upregulated pro-inflammatory factors production and p-p65 protein level in lung cells caused by hyperoxia were decreased by montelukast treatment. montelukast 138-149 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 30802715-12 2019 In addition, pretreatment with Ha-EtOAc could suppress the nuclear translocation of p65 and the phosphorylation of Erk1/2, p38 and JNK. ha-etoac 31-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 30926814-6 2019 Amongst ROS-activating transcription factors, RelA/p65 induces Gremlin-1 transcription, which antagonizes induction of anabolic genes such as Sox9, Col2a1, and Acan by bone morphogenetic proteins. Reactive Oxygen Species 8-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 30871577-11 2019 We also found that UA affected critical cell signaling pathways, specifically by enhancing cerebral AMPK activation, decreasing the activation of P65NF-kappaB and P38MAPK, and suppressing Bace1 and APP degradation. 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one 19-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 146-158 30930772-9 2019 1,8-Cineole and rosiglitazone blocked the LPS-induced IkappaBalpha degradation and NF-kappaB p65 nucleus translocation, which could be reversed by the pretreatment of GW9662 or silence of PPAR-gamma gene. Eucalyptol 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 93-96 30850637-7 2019 The downstream targets of PPARalpha, PPARdelta, and RELA in this network significantly overlapped with telmisartan-induced differentially expressed genes (DEGs), which were verified in palmitate-treated Hepa1c1c7 cell line. Telmisartan 103-114 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 52-56 30850637-7 2019 The downstream targets of PPARalpha, PPARdelta, and RELA in this network significantly overlapped with telmisartan-induced differentially expressed genes (DEGs), which were verified in palmitate-treated Hepa1c1c7 cell line. Palmitates 185-194 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 52-56 30930772-6 2019 Western blotting indicated that 1,8-cineole significantly decreased the phosphorylation of NF-kappaB p65 and increased the expression of PPAR-gamma in the thoracic aorta tissue. Eucalyptol 32-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 30930772-9 2019 1,8-Cineole and rosiglitazone blocked the LPS-induced IkappaBalpha degradation and NF-kappaB p65 nucleus translocation, which could be reversed by the pretreatment of GW9662 or silence of PPAR-gamma gene. Rosiglitazone 16-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 93-96 30930772-9 2019 1,8-Cineole and rosiglitazone blocked the LPS-induced IkappaBalpha degradation and NF-kappaB p65 nucleus translocation, which could be reversed by the pretreatment of GW9662 or silence of PPAR-gamma gene. 2-chloro-5-nitrobenzanilide 167-173 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 93-96 30218457-2 2019 Our in vitro experiments have confirmed that SSE treatment causes a transient increase in intracellular reactive oxygen species (ROS) levels, resulting in the inhibition of nuclear transcription factor-kappaB (NF-kappaB) signaling and p65 and nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha phosphorylation levels in 4T1 cells. Reactive Oxygen Species 129-132 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 235-326 30830898-9 2019 Mechanistically, we identified calycosin inhibited diabetes-induced inflammation in kidneys by suppressing the phosphorylation of IKBa and NF-kappaB p65 in vitro and in vivo. 7,3'-dihydroxy-4'-methoxyisoflavone 31-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 149-152 30615971-5 2019 TM and TG-treated hepatocytes activated p65 NF-kappaB and JNK, the pathways that respond to stress stimuli and playing a central role in inflammation and apoptosis, respectively. Thapsigargin 7-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-53 30746687-8 2019 In the further mechanism studies, we found that the anti-inflammatory effect of myricetin was mediated by inhibiting LPS-induced phosphorylation of AKT, IKK-alpha, IkappaB-alpha, and P65 in vivo and in vitro. myricetin 80-89 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 183-186 30367332-6 2019 RESULTS: SDG supplementation in the mice significantly reduced tumor volume and expression of phospho-p65 and NF-kappaB target genes (P < 0.05). secoisolariciresinol diglucoside 9-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-105 30717768-11 2019 Further mechanism study revealed that melatonin enhanced the antitumor effect of vemurafenib by abrogating nucleus translocation of NF-kappaB p50/p65 and their binding at iNOS and hTERT promoters, thereby suppressing the expression of iNOS and hTERT. Melatonin 38-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 146-149 30717768-11 2019 Further mechanism study revealed that melatonin enhanced the antitumor effect of vemurafenib by abrogating nucleus translocation of NF-kappaB p50/p65 and their binding at iNOS and hTERT promoters, thereby suppressing the expression of iNOS and hTERT. Vemurafenib 81-92 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 146-149 30537636-3 2019 Moreover, BEMB suppressed the protein and mRNA expression levels of nuclear factor (NF)-kappaB (p65 and inhibitor of NF-kappaB [IkappaB]-A) in RAW264.7 cells and zebrafish embryo, respectively. bemb 10-14 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-126 30483725-8 2019 The mechanism underlying the anti-inflammatory effects of isorhamnetin was subsequently evaluated; this flavonoid inhibited the nuclear factor (NF)-kappaB signaling pathway by disrupting degradation and phosphorylation of inhibitor kappaB-alpha in the cytoplasm and blocking translocation of NF-kappaB p65 into the nucleus. 3-methylquercetin 58-70 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 302-305 30483725-8 2019 The mechanism underlying the anti-inflammatory effects of isorhamnetin was subsequently evaluated; this flavonoid inhibited the nuclear factor (NF)-kappaB signaling pathway by disrupting degradation and phosphorylation of inhibitor kappaB-alpha in the cytoplasm and blocking translocation of NF-kappaB p65 into the nucleus. Flavonoids 104-113 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 302-305 30399318-4 2019 Both ALP and cPLA2 inhibitor, methylarachidonyl fluorophosphate (MAFP), suppressed oAbeta-induced translocation of NFkappaB p65 subunit to nuclei, suggesting that cPLA2 activation and calcium influx are essential for oAbeta-induced NFkappaB activation. methylarachidonyl fluorophosphate 30-63 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 124-127 32958515-4 2020 The highest-ranked drug was the macrolide antibiotic Clarithromycin, which has previously been reported to have anti-inflammatory effects in aseptic conditions.Clarithromycin"s effects were validated in several experiments: it influenced NF-kappaB mediated transcription in murine peritoneal macrophages and intestinal enteroids; it suppressed NF-kappaB protein shuttling in murine reporter enteroids; it suppressed NF-kappaB (p65) DNA binding in the small intestine of mice exposed to LPS, and it reduced the severity of dextran sulphate sodium-induced colitis in C57BL/6 mice. Macrolides 32-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 427-430 32958515-4 2020 The highest-ranked drug was the macrolide antibiotic Clarithromycin, which has previously been reported to have anti-inflammatory effects in aseptic conditions.Clarithromycin"s effects were validated in several experiments: it influenced NF-kappaB mediated transcription in murine peritoneal macrophages and intestinal enteroids; it suppressed NF-kappaB protein shuttling in murine reporter enteroids; it suppressed NF-kappaB (p65) DNA binding in the small intestine of mice exposed to LPS, and it reduced the severity of dextran sulphate sodium-induced colitis in C57BL/6 mice. Clarithromycin 53-67 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 427-430 32958515-4 2020 The highest-ranked drug was the macrolide antibiotic Clarithromycin, which has previously been reported to have anti-inflammatory effects in aseptic conditions.Clarithromycin"s effects were validated in several experiments: it influenced NF-kappaB mediated transcription in murine peritoneal macrophages and intestinal enteroids; it suppressed NF-kappaB protein shuttling in murine reporter enteroids; it suppressed NF-kappaB (p65) DNA binding in the small intestine of mice exposed to LPS, and it reduced the severity of dextran sulphate sodium-induced colitis in C57BL/6 mice. Clarithromycin 160-174 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 427-430 30529602-7 2019 S-nitrosylation of NFkB p65 subunit, which is induced by nitric oxide derived from nitric oxide synthase 2, facilitated subsequent sulfide-induced persulfidation of p65 and transcription of anti-apoptotic genes. Nitric Oxide 57-69 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 24-27 30529602-7 2019 S-nitrosylation of NFkB p65 subunit, which is induced by nitric oxide derived from nitric oxide synthase 2, facilitated subsequent sulfide-induced persulfidation of p65 and transcription of anti-apoptotic genes. Nitric Oxide 57-69 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 165-168 30529602-7 2019 S-nitrosylation of NFkB p65 subunit, which is induced by nitric oxide derived from nitric oxide synthase 2, facilitated subsequent sulfide-induced persulfidation of p65 and transcription of anti-apoptotic genes. Sulfides 131-138 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 24-27 30529602-7 2019 S-nitrosylation of NFkB p65 subunit, which is induced by nitric oxide derived from nitric oxide synthase 2, facilitated subsequent sulfide-induced persulfidation of p65 and transcription of anti-apoptotic genes. Sulfides 131-138 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 165-168 30099676-10 2019 The nuclear quantity of p65 in the LPS + rutin group decreased significantly in a rutin dose-dependent manner. Rutin 41-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 24-27 30099676-10 2019 The nuclear quantity of p65 in the LPS + rutin group decreased significantly in a rutin dose-dependent manner. Rutin 82-87 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 24-27 30674969-0 2019 Astragaloside IV inhibits glucose-induced epithelial-mesenchymal transition of podocytes through autophagy enhancement via the SIRT-NF-kappaB p65 axis. astragaloside A 0-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 142-145 30674969-0 2019 Astragaloside IV inhibits glucose-induced epithelial-mesenchymal transition of podocytes through autophagy enhancement via the SIRT-NF-kappaB p65 axis. Glucose 26-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 142-145 30674969-5 2019 We observed that AS-IV inhibited glucose-induced podocyte EMT and enhanced autophagy by decreasing NF-kappaB subunit p65 acetylation as well as increasing Sirtuin1 (SIRT1) expression. Glucose 33-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-120 30312753-7 2019 P-gp, CYP3A, PXR and NF-kappaB p65 were elevated in bEnd.3 cells incubated with l-glutamate, CBZ or CBZ pretreated by l-glutamate for 30 min. Glutamic Acid 80-91 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-34 30312753-7 2019 P-gp, CYP3A, PXR and NF-kappaB p65 were elevated in bEnd.3 cells incubated with l-glutamate, CBZ or CBZ pretreated by l-glutamate for 30 min. Carbamazepine 93-96 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-34 30312753-7 2019 P-gp, CYP3A, PXR and NF-kappaB p65 were elevated in bEnd.3 cells incubated with l-glutamate, CBZ or CBZ pretreated by l-glutamate for 30 min. Carbamazepine 100-103 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-34 30312753-7 2019 P-gp, CYP3A, PXR and NF-kappaB p65 were elevated in bEnd.3 cells incubated with l-glutamate, CBZ or CBZ pretreated by l-glutamate for 30 min. Glutamic Acid 118-129 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-34 30312753-10 2019 These data suggested that overexpression of P-gp and CYP3A during seizures and treated with CBZ may be regulated by PXR or NF-kappaB p65 activity and expression, which revealed a mechanism underlying the development of DRE. Carbamazepine 92-95 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 133-136 30521868-9 2019 Further, AP effectively inhibited UVA-induced activation of pro-angiogenic (iNOS and VEGF), inflammatory proteins (TNF-alpha, IL-6, and COX-2) expression and prevented the activation of NF-kappaB p65 in the mouse skin. uva 34-37 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 196-199 30399318-4 2019 Both ALP and cPLA2 inhibitor, methylarachidonyl fluorophosphate (MAFP), suppressed oAbeta-induced translocation of NFkappaB p65 subunit to nuclei, suggesting that cPLA2 activation and calcium influx are essential for oAbeta-induced NFkappaB activation. MAFP 65-69 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 124-127 30399318-4 2019 Both ALP and cPLA2 inhibitor, methylarachidonyl fluorophosphate (MAFP), suppressed oAbeta-induced translocation of NFkappaB p65 subunit to nuclei, suggesting that cPLA2 activation and calcium influx are essential for oAbeta-induced NFkappaB activation. oabeta 83-89 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 124-127 31257297-8 2019 We then assessed the efficacy of anti-nuclear factor-kappa B (NF-kappaB) (RelA) siRNA (siRelA)-encapsulated DOPE/CHEMS liposomes with AT1002 in AD model mice. 1,2-dielaidoylphosphatidylethanolamine 108-112 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-78 30626153-5 2019 Further analyses demonstrated that COS induced the phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38, p85 and Akt, and the nuclear translocation of p65, indicating that they are able to activate the mitogen-activated protein kinases (MAPKs) and phosphoinositide 3-kinases (PI3K)/Akt signaling pathways dependent on nuclear factor (NF)-kappaB activation. oligochitosan 35-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 197-200 30296701-7 2019 Also, fenofibrate treatment decreased NF-kappaB p65 and cyclooxygenase 2 proteins in aortas. Fenofibrate 6-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 48-51 30806288-8 2019 Furthermore, oral administration of DA decreased the level of myeloperoxidase (MPO) and inhibited the expression of p65-NF-kappaB, p-IkappaB-alpha, and p-IKK as well as several inflammatory factors, including TNF-alpha, IL-1beta, and IL-6, in the colonic tissues. daidzein 36-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 116-129 30342159-11 2019 This study demonstrates, for the first time, that MGO accumulation increases the antiangiogenic factor HoxA5 via NF-kB-p65, thereby impairing the angiogenic ability of endothelial cells. Pyruvaldehyde 50-53 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-122 29916120-10 2019 Taken together, these findings indicate that silibinin-induced autophagy is mediated by up-regulation of PPARalpha-sirt1-AMPK, contributing to repression of type I collagen-enhanced migration in murine 3T3-L1 preadipocytes through down-regulation of phosphorylated NF-kappaB p65. Silybin 45-54 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 275-278 30152858-0 2018 3"-Sialyllactose as an inhibitor of p65 phosphorylation ameliorates the progression of experimental rheumatoid arthritis. 3'-sialyllactose 0-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 36-39 30352316-8 2018 Additionally, Salmeterol suppressed nuclear translocation of nuclear factor kappa-B (NF-kappaB) p65 by inhibiting the IkappaB-alpha degradation and TAK1 (transforming growth factor-beta-activated kinase1) phosphorylation. Salmeterol Xinafoate 14-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-99 30391477-5 2018 3-DA attenuated the release of pro-inflammatory cytokines IL-6 and TNF-alpha, inhibited the degradation and phosphorylation of IkappaBalpha, and suppressed the nuclear translocation of NF-kappaB p65 as well as the phosphorylation of Akt at Ser473 in LPS-stimulated RAW 264.7 macrophage cells. 3-da 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 195-198 30618760-9 2018 Pretreatment with costunolide could reduce the expression of toll-like receptor 4, myeloid differentiation factor 88, p65 (Nucleus), phosphorylated IkappaB kinase alpha/beta, inhibitor of nuclear factor kappa-B kinase, inhibitor kappa Balpha and prevent the expression of phosphorylated inhibitor kappa B kinase which repressed translocation of p65 from cytoplasm to nucleus. costunolide 18-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-121 30618760-9 2018 Pretreatment with costunolide could reduce the expression of toll-like receptor 4, myeloid differentiation factor 88, p65 (Nucleus), phosphorylated IkappaB kinase alpha/beta, inhibitor of nuclear factor kappa-B kinase, inhibitor kappa Balpha and prevent the expression of phosphorylated inhibitor kappa B kinase which repressed translocation of p65 from cytoplasm to nucleus. costunolide 18-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 345-348 30152858-9 2018 Notably, phosphorylation of p65, which is a key protein in the NF-kappaB signalling pathway, was totally blocked by 3"-SL in the RA models. 3'-sialyllactose 116-121 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 28-31 30409067-6 2018 Renal lesions, increased expressions of B1R, B2R, Kim-1, Lipocalin-2, and NF-kappaB p65 subunit on tubular epithelial cells were all observed in TCE-sensitized mice. Trichloroethylene 145-148 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 30003404-6 2018 Western blot analysis showed that terpinen-4-ol significantly attenuated LPS-induced phosphorylation of IkappaBalpha and NF-kappaB p65. terpinenol-4 34-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 131-134 29534626-13 2018 PDTC pretreatment attenuated TCE-induced up-regulation of p65 and its phosphorylation, complement deposition, cytokine release, and renal damage. Trichloroethylene 29-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 58-61 30321818-9 2018 NF-kappaB p65 nuclear translocation, but not beta-catenin nuclear translocation, was induced by LMW-OPS. lmw-ops 96-103 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 10-13 30306659-5 2018 Berberine suppressed the viral infection-induced up-regulation of TLR7 signaling pathway, such as TLR7, MyD88, and NF-kappaB (p65), at both the mRNA and protein levels. Berberine 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 126-129 30463239-6 2018 Consistent with the in vitro studies, TQ-6 also suppressed the expression of iNOS, TNF-alpha, and p65 in the mouse model with acute liver injury induced by LPS. tq-6 38-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 98-101 29481885-5 2018 MPTP induced translocation of p65 and p52, two subunits of NF-kappaB family, to nucleus where they had been found to dimerize. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 30-33 29481885-6 2018 Therefore, MPTP induced TNF-alpha signaling through TNFR2 mediated pathway and recruited p65-p52 dimer in hippocampal nucleus which is reported to have protective effect on hippocampal neurons indicated by unchanged neuronal count in hippocampus in treated groups with respect to control. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 11-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 89-92 30486413-9 2018 Expression and activation of NF-kappaB p65 was promoted in kidneys of adenine treated mice, but suppressed in kidneys of mice exposed to fucoidan from Laminaria japonica or allopurinol. Adenine 70-77 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 39-42 30486413-9 2018 Expression and activation of NF-kappaB p65 was promoted in kidneys of adenine treated mice, but suppressed in kidneys of mice exposed to fucoidan from Laminaria japonica or allopurinol. Allopurinol 173-184 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 39-42 30155758-9 2018 Curcumin has similar effects with 3-MA, in which curcumin inhibited NF-kappaB by preventing the translocation of NF-kappaB p65. Curcumin 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 123-126 30463239-5 2018 TQ-6 suppressed, LPS-stimulated p38 MAPK phosphorylation, IkappaBalpha degradation, and p65 nuclear translocation in cells. tq-6 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 30257328-6 2018 What"s more, LPS-induced activation and degradation of IkappaBalpha followed by translocation of the p65 from the cytoplasm to the nucleus were attenuated by chelidonine. chelidonine 158-169 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 30257331-6 2018 Mechanistically, hyperoside reduced the expression of receptor activator of nuclear factor-kappaB ligand (RANKL), TNF-receptor-associated factor 6 (TRAF6), phosphorylated inhibitor of nuclear factor-kappaB alpha (IkappaBalpha), NF-kB p65, and nuclear factor of activated T cell cytoplasmic 1 (NFATc1) and promoted the expression of osteoprotegerin (OPG). hyperoside 17-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 234-237 30519584-6 2018 Further, treatment with CQ decreased the levels of active p65, TNF-alpha, MCP-1, and MMP-9 in cells underdesiccation stress. Chloroquine 24-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 58-61 30155758-9 2018 Curcumin has similar effects with 3-MA, in which curcumin inhibited NF-kappaB by preventing the translocation of NF-kappaB p65. 3-methyladenine 34-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 123-126 30155758-9 2018 Curcumin has similar effects with 3-MA, in which curcumin inhibited NF-kappaB by preventing the translocation of NF-kappaB p65. Curcumin 49-57 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 123-126 30173054-5 2018 The results showed that barbaloin decreased the phosphorylation levels of IkappaBalpha and NF-kappaB p65, leading to a reduction in the expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6). barbaloin 24-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 30106126-2 2018 Previous studies have indicated that microRNA (miR)-291b-3p regulates the metabolism of lipids and glucose in the liver via targeting adenosine monophosphate-activated kinase alpha1 and transcription factor p65. Glucose 99-106 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 207-210 30173054-7 2018 Additionally, a pharmacological inhibitor of PI3K/AKT, LY294002, also restrained the phosphorylation levels of IkappaBalpha and NF-kappaB p65 and thereby decreased the expression of pro-inflammatory cytokines. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 55-63 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 138-141 30410469-9 2018 In addition, sodium butyrate treatment can inhibit the pancreatic HMGB1 and NF-kappaB p65 protein expression. Butyric Acid 13-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 86-89 30056058-7 2018 AGEs or DPP-4 up-regulated NF-kappaB p65 or MCP-1 mRNA levels in tubular cells, which were suppressed by linagliptin, an inhibitor of DPP-4. Linagliptin 105-116 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 37-40 29441825-7 2018 In addition, PQ significantly enhanced the expressions of HSP60 and TLR4 proteins in BV2 cells, as well as NF-kappaB-p65, c-fos, and c-jun mRNA. Paraquat 13-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-120 30498366-8 2018 WU-FA-01 significantly suppressed the expression levels of p65, IkappaB-alpha, and p-IkappaB-alpha in the TPA-induced mouse ear model. wu-fa 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-62 30405614-10 2018 Further examination revealed an increase in I-kappaBalpha and a decrease in phospho-relA levels in TSA-treated BMMCs, suggesting that TSA alters transcriptional processes, resulting in enhancement of I-kappaBalpha transcription and decreased NF-kappaB activation. trichostatin A 99-102 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-88 30322375-10 2018 Moreover, SE inhibited CCl4-induced nuclear translocation of hepatic nuclear factor kappa B (NF-kappaB) p65 and phosphorylation of mitogen-activated protein kinase (MAPK). Selenium 10-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 104-107 30194946-0 2018 NIR-light and GSH activated cytosolic p65-shRNA delivery for precise treatment of metastatic cancer. Glutathione 14-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 38-41 30093003-3 2018 RPS-1 stimulated the production of nitric oxide and tumor necrosis factor-alpha by triggering phosphorylation of mitogen-activated protein kinases and nuclear translocation of nuclear factor kappa B p65 in RAW 264.7 macrophage cells. Nitric Oxide 35-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 199-202 30214582-10 2018 Furthermore, osthole downregulated the expression of VEGF and NF-kappaB p65, and upregulated IkappaB-alpha expression in tumor and adjacent tissues. osthol 13-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 30223923-9 2018 Further studies revealed that TFA significantly inhibited iNOS and COX-2 protein levels, the phosphorylations of p38 and JNK in MAPKs pathway and IKKalpha/beta, IkappaBalpha and the expression of nuclear NF-kappaB p65 in NF-kappaB pathway in LPS-stimulated RAW 264.7 cells. Trifluoroacetic Acid 30-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 214-217 29885354-8 2018 However, the addition of Klotho to the TCDD + LPS-cotreated cells significantly increased PDLIM2 and decreased p65 activation and NLRP3 (p < 0.05). Polychlorinated Dibenzodioxins 39-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 111-114 29885354-11 2018 Taken together, TCDD may increase testicular inflammation by affecting the secretion of proinflammatory cytokines in Sertoli cells via the Klotho/PDLIM2/p65 pathway, which influences the testicular microenvironment and induces germ cell apoptosis. Polychlorinated Dibenzodioxins 16-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 153-156 30201812-6 2018 Mechanistically, Psen1 associated with the BCR-CK2alpha complex, which is required for phosphorylation of p65 at serine 529. Serine 113-119 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 106-109 30201812-7 2018 Consistently, TNF-alpha-induced phosphorylation of p65 at serine 529 was significantly decreased in Psen1-deficient cells. Serine 58-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 30344887-13 2018 Further studies revealed that taraxasterol significantly inhibited the ethanol-induced upregulation of CYP2E1, increased the ethanol-induced downregulation of Nrf2 and HO-1, and inhibited the degradation of inhibitory kappa Balpha (IkappaBalpha) and the expression level of NF-kappaB p65 in liver tissues of ethanol-induced mice. taraxasterol 30-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 284-287 30237706-0 2018 Nucleosides isolated from Ophiocordyceps sinensis inhibit cigarette smoke extract-induced inflammation via the SIRT1-nuclear factor-kappaB/p65 pathway in RAW264.7 macrophages and in COPD mice. Nucleosides 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 139-142 30254426-0 2018 Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-kappaB p65 subunit. astragaloside A 0-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 135-138 30237706-8 2018 Moreover, the nucleosides elevated SIRT1 activation and suppressed nuclear factor-kappaB (NF-kappaB)/p65 activation in vitro and in vivo. Nucleosides 14-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 30237706-11 2018 Conclusion: These results show that the nucleosides suppressed COPD inflammation through the SIRT1-NF-kappaB/p65 pathway, suggesting that the nucleosides may be partly responsible for the therapeutic effects of cultured C. sinensis on COPD patients. Nucleosides 40-51 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-112 29721581-10 2018 Our results showed that glycyrrhizin significantly inhibited RANKL-induced osteoclastogenesis, downregulated the expression of NFATc1, c-fos, TRAP, CK, DC-STAMP, and OSCAR, and inhibited p65, p38, and JNK. Glycyrrhizic Acid 24-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 187-190 30237706-11 2018 Conclusion: These results show that the nucleosides suppressed COPD inflammation through the SIRT1-NF-kappaB/p65 pathway, suggesting that the nucleosides may be partly responsible for the therapeutic effects of cultured C. sinensis on COPD patients. Nucleosides 142-153 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-112 29890468-9 2018 Additionally, calycosin significantly reduced cerulein-induced pancreatic edema, inhibited MPO activity and increased superoxide dismutase (SOD) activity, and inhibited the expression of NF-kappaB/p65 and phosphorylation of the inhibitor of NF-kappaB (IkappaBalpha) and p38 MAPK. 7,3'-dihydroxy-4'-methoxyisoflavone 14-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 197-200 29751039-7 2018 WCG-O inhibited the activation of IkappaK-alpha/beta, the phosphorylation of IkappaB-alpha, and degradation of IkappaB-alpha, which results in the inhibition of p65 nuclear accumulation and NF-kappaB activation. wcg-o 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 161-164 30186451-6 2018 Effects of andrographolide on the expression of L-10, STAT3, NF-kappabeta p65 and NF-kappabeta p50 were investigated by western blot analysis. andrographolide 11-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-77 30186451-7 2018 Results indicated that andrographolide treatment reduced serum levels of TNF-alpha, hs-CRP and cTnl, increased the expression levels of IL-10 and STAT3 and reduced the expression levels of NF-kappabeta p65 and NF-kappabeta p50 and the phosphorylation levels of phosphoinositide 3-kinase (P13K) and AKT in the heart tissues of mice with VMC. andrographolide 23-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 202-205 30230981-10 2018 Our results showed that metformin inhibited the phosphorylation of I-kappaBalpha and p65 while it activated AMPK. Metformin 24-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 85-88 30114253-7 2018 Additionally, significantly increased levels of phosphorylated p65 (NF-kappaB) and MAPK signaling proteins were observed in lung tissue of mice that received B19V-VP1u or HBoV-VP1u compared to those of mice that received PBS. Lead 221-224 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 63-66 30214410-9 2018 The results showed that magnoflorine suppressed the levels of phosphorylated p65, IkappaBalpha, p38, ERK, and JNK. magnoflorine 24-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-80 30150770-4 2018 Here we showed that the pro-apoptotic acetylation mode of RelA, involving a general lysine deacetylation of the subunit with the exclusion of the lysine 310, is evident in the lumbar spinal cord of SOD1(G93A) mice, a murine model of ALS. Lysine 84-90 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 58-62 30150770-4 2018 Here we showed that the pro-apoptotic acetylation mode of RelA, involving a general lysine deacetylation of the subunit with the exclusion of the lysine 310, is evident in the lumbar spinal cord of SOD1(G93A) mice, a murine model of ALS. Lysine 146-152 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 58-62 30150770-5 2018 The administration of the HDAC inhibitor MS-275 and the AMPK/sirtuin 1 activator resveratrol restored the normal RelA acetylation in SOD1(G93A) mice. entinostat 41-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 113-117 30150770-5 2018 The administration of the HDAC inhibitor MS-275 and the AMPK/sirtuin 1 activator resveratrol restored the normal RelA acetylation in SOD1(G93A) mice. Resveratrol 81-92 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 113-117 30150770-8 2018 In conclusion, we here demonstrate that MS-275 and resveratrol restore the acetylation state of RelA in the spinal cord, delaying the onset and increasing the lifespan of SOD1(G93A) mice. entinostat 40-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-100 30150770-8 2018 In conclusion, we here demonstrate that MS-275 and resveratrol restore the acetylation state of RelA in the spinal cord, delaying the onset and increasing the lifespan of SOD1(G93A) mice. Resveratrol 51-62 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-100 30098604-10 2018 Moreover, K284-6111 treatment suppressed p50 and p65 translocation into the nucleus, and phosphorylation of IkappaB in vivo and in vitro. methylene iodide 10-14 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 49-52 30210674-8 2018 Furthermore, rivaroxaban inhibited the phosphorylation of TAK1 and p65. Rivaroxaban 13-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 67-70 29775898-13 2018 In vitro experimental results showed that 4-PBA suppressed PE particle-induced ERK1/2, p38, and JNK activation, NFATc1 and c-Fos upregulation, as well as NF-kappaB p65 nucleus translocation. 4-phenylbutylamine 42-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 164-167 29890414-5 2018 The inhibitory effects of DGP on these inflammatory mediators in LPS-stimulated microglial BV2 cells were regulated by NF-kappaB signaling through blocking p65 nuclear translocation and NF-kappaB p65/DNA binding activity. dgp 26-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 156-159 29787986-16 2018 ASTF can obviously inhibit the degredation of IkappaBa and inhibit the nucleus translocations of p-NF-kappaB p65, p-ERK1/2 and p-p38 in RAW 264.7 cells stimulated by LPS. astf 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-112 29733843-17 2018 Quercetin-3-glucoside reduced the levels of p65 (P < .05), a member of the nuclear factor-kappaB transcription factor family, but augmented the levels of the inhibitor of kappaBalpha (P < .05), which suppresses p65 nuclear translocation. isoquercitrin 0-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 44-47 29733843-17 2018 Quercetin-3-glucoside reduced the levels of p65 (P < .05), a member of the nuclear factor-kappaB transcription factor family, but augmented the levels of the inhibitor of kappaBalpha (P < .05), which suppresses p65 nuclear translocation. isoquercitrin 0-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 217-220 29890414-5 2018 The inhibitory effects of DGP on these inflammatory mediators in LPS-stimulated microglial BV2 cells were regulated by NF-kappaB signaling through blocking p65 nuclear translocation and NF-kappaB p65/DNA binding activity. dgp 26-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 196-199 30262993-7 2018 Furthermore, the reduction in inflammation and CD68 macrophage activation correlated with inhibition of toll-like receptor (TLR)-4/NF-kappaB p65 signaling pathway by polydatin treatment. polydatin 166-175 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 141-144 30273050-6 2018 Immunohistochemical staining showed that levels of nuclear factor-kappa B p65 and beta-catenin were attenuated by TAEE in the colon tissues of AOM/DSS-treated mice. Dextran Sulfate 147-150 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-77 30288224-5 2018 Mechanistic investigations demonstrated that GA down-regulated the expressions of IkappaBalpha and p65 and blocked the phosphorylation of IkappaBalpha and p65 in TPA-induced mouse skin. Glycyrrhizic Acid 45-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-102 30288224-5 2018 Mechanistic investigations demonstrated that GA down-regulated the expressions of IkappaBalpha and p65 and blocked the phosphorylation of IkappaBalpha and p65 in TPA-induced mouse skin. Glycyrrhizic Acid 45-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 155-158 30288224-5 2018 Mechanistic investigations demonstrated that GA down-regulated the expressions of IkappaBalpha and p65 and blocked the phosphorylation of IkappaBalpha and p65 in TPA-induced mouse skin. Tetradecanoylphorbol Acetate 162-165 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 155-158 29792864-5 2018 The results revealed that delavatine A significantly decreased LPS-induced the activation of nuclear factor-kappaB (NF-kappaB) by suppressing the p65 subunits, and the phosphorylation of IkappaBalpha, while not related to PI3K/Akt or MAPK pathways. delavatine 26-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 146-149 30038210-4 2018 PolyI:C induced a canonical immune response in the SVZ; it increased mRNA expression of its toll-like receptor 3 (Tlr3) and downstream transcription factors RelA and Sp1. Poly I-C 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 157-161 30038210-6 2018 Dysbindin-1 loss in Sdy mice blocked the polyI:C-induced increases in mRNA expression of Tlr3, RelA and Sp1 in the SVZ. Poly I-C 41-48 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-99 29568921-6 2018 Whether fisetin treatment attenuated OVA-induced airway inflammation was examined via inflammation inhibition through MyD88-related NF-kappaB (p65) signaling pathway. fisetin 8-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 143-146 29229421-9 2018 Moreover, LPS upregulated NF-kB p65 expression and IkappaB degradation was significantly decreased after BA-25 treatment. Barium 105-107 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 32-35 29790745-12 2018 Furthermore, vanillin diminished the phosphorylation of mitogen-activated protein kinases (MAPKs) and reduced the number of p65-positive cells, proliferating cells, and granulocytes in colon tissues with statistical significance. vanillin 13-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 124-127 30037569-6 2018 Furthermore, the thiol groups of p65 were modified by CAPE, and the inhibitory effects of CAPE and DBL on the p65 phosphorylation and nitrite production were reversed by pretreatment with thiol-containing reagents. Nitrites 134-141 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-36 30037569-6 2018 Furthermore, the thiol groups of p65 were modified by CAPE, and the inhibitory effects of CAPE and DBL on the p65 phosphorylation and nitrite production were reversed by pretreatment with thiol-containing reagents. Sulfhydryl Compounds 188-193 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-36 30037569-6 2018 Furthermore, the thiol groups of p65 were modified by CAPE, and the inhibitory effects of CAPE and DBL on the p65 phosphorylation and nitrite production were reversed by pretreatment with thiol-containing reagents. Sulfhydryl Compounds 188-193 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 110-113 30037569-7 2018 These results suggest that CAPE has strong inhibitory effects on the NF-kappaB activation that are associated with the modification of thiol groups and phosphorylation of p65. caffeic acid phenethyl ester 27-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 171-174 29973878-6 2018 For underlying molecular mechanisms, 18beta-GA inhibited RANKL-induced phosphorylation of p65, p50, and IkappaB, blocked p65 nuclear translocation and decreased the DNA-binding activity of NF-kappaB. 18alpha-glycyrrhetinic acid 37-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-93 29973878-6 2018 For underlying molecular mechanisms, 18beta-GA inhibited RANKL-induced phosphorylation of p65, p50, and IkappaB, blocked p65 nuclear translocation and decreased the DNA-binding activity of NF-kappaB. 18alpha-glycyrrhetinic acid 37-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-124 29973940-7 2018 Activation of the GPR84 receptor with a selective agonist, 6-(octylamino) pyrimidine-2,4(1H,3H)-dione (6-n-octylaminouracil, 6-OAU), enhanced the expression of phosphorylated Akt, p-ERK, and p65 nuclear translocation under inflammatory conditions and elevated the expression levels of the inflammatory mediators TNFalpha, IL-6, IL-12B, CCL2, CCL5, and CXCL1. 6-(octylamino) pyrimidine-2,4(1h,3h)-dione 59-101 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 191-194 29680708-3 2018 We showed that apelin-13 treatment reversed a decrease in SIRT1 and an increase in acetylated p65 (lysine 310) proteins" expression in hippocampus of CNH-treated mice, indicating that apelin-13 inhibited NF-kappaB signaling pathway by activating SIRT1. Lysine 99-105 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 94-97 29680708-3 2018 We showed that apelin-13 treatment reversed a decrease in SIRT1 and an increase in acetylated p65 (lysine 310) proteins" expression in hippocampus of CNH-treated mice, indicating that apelin-13 inhibited NF-kappaB signaling pathway by activating SIRT1. 1-hydroxy-11-norcadinan-5-en-4-one 150-153 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 94-97 29680708-5 2018 We also showed that resveratrol treatment decreased IL-1beta, IL-6, TNF-alpha, PCNA, Bcl-2, and acetyl-p65 levels, but increased Bax and caspase 3 levels in hippocampus, suggesting a suppressive effect of resveratrol on cellular neuroinflammation and proliferation while a promotive effect on apoptosis of microglia in hippocampus. Resveratrol 20-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 103-106 29946349-10 2018 Moreover, IRN significantly suppressed the phosphorylation of NF-kappaB p65 and IkappaBalpha in the brain tissues of AlCl3-treated mice. Aluminum Chloride 117-122 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 29899429-6 2018 Curcumin suppressed eIF2alpha phosphorylation, which is induced by endoplasmic reticulum (ER) stress, macrophage accumulation and nuclear factor-kappaB (NF-kappaB) p65 and leptin expression, whereas it"s anti-inflammatory effect was inadequate to decrease TNF-alpha and IFN-gamma levels. Curcumin 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 164-167 30037569-0 2018 Inhibition of nuclear factor-kappaB p65 phosphorylation by 3,4-dihydroxybenzalacetone and caffeic acid phenethyl ester. 3,4-dihydroxybenzalacetone 59-85 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 36-39 30037569-0 2018 Inhibition of nuclear factor-kappaB p65 phosphorylation by 3,4-dihydroxybenzalacetone and caffeic acid phenethyl ester. caffeic acid phenethyl ester 90-118 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 36-39 30037569-4 2018 Consistent with these results, induction of NF-kappaB downstream genes, such as Nitric oxide synthase, interleukin 1 beta, and interleukin 6, and translocation of NF-kappaB p65 to the nucleus were reduced after LPS stimulation, to a greater extent with CAPE than with DBL. caffeic acid phenethyl ester 253-257 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 173-176 30037569-4 2018 Consistent with these results, induction of NF-kappaB downstream genes, such as Nitric oxide synthase, interleukin 1 beta, and interleukin 6, and translocation of NF-kappaB p65 to the nucleus were reduced after LPS stimulation, to a greater extent with CAPE than with DBL. 3,4-dihydroxybenzalacetone 268-271 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 173-176 30037569-5 2018 Interestingly, the phosphorylation of p65 was reduced by both compounds, especially by CAPE, even when the level of IkappaB was not altered. caffeic acid phenethyl ester 87-91 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 38-41 30037569-6 2018 Furthermore, the thiol groups of p65 were modified by CAPE, and the inhibitory effects of CAPE and DBL on the p65 phosphorylation and nitrite production were reversed by pretreatment with thiol-containing reagents. Sulfhydryl Compounds 17-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-36 30037569-6 2018 Furthermore, the thiol groups of p65 were modified by CAPE, and the inhibitory effects of CAPE and DBL on the p65 phosphorylation and nitrite production were reversed by pretreatment with thiol-containing reagents. Sulfhydryl Compounds 17-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 110-113 30037569-6 2018 Furthermore, the thiol groups of p65 were modified by CAPE, and the inhibitory effects of CAPE and DBL on the p65 phosphorylation and nitrite production were reversed by pretreatment with thiol-containing reagents. caffeic acid phenethyl ester 54-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-36 30037569-6 2018 Furthermore, the thiol groups of p65 were modified by CAPE, and the inhibitory effects of CAPE and DBL on the p65 phosphorylation and nitrite production were reversed by pretreatment with thiol-containing reagents. caffeic acid phenethyl ester 54-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 110-113 30037569-6 2018 Furthermore, the thiol groups of p65 were modified by CAPE, and the inhibitory effects of CAPE and DBL on the p65 phosphorylation and nitrite production were reversed by pretreatment with thiol-containing reagents. caffeic acid phenethyl ester 90-94 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-36 30037569-6 2018 Furthermore, the thiol groups of p65 were modified by CAPE, and the inhibitory effects of CAPE and DBL on the p65 phosphorylation and nitrite production were reversed by pretreatment with thiol-containing reagents. caffeic acid phenethyl ester 90-94 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 110-113 30037569-6 2018 Furthermore, the thiol groups of p65 were modified by CAPE, and the inhibitory effects of CAPE and DBL on the p65 phosphorylation and nitrite production were reversed by pretreatment with thiol-containing reagents. 3,4-dihydroxybenzalacetone 99-102 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-36 30037569-6 2018 Furthermore, the thiol groups of p65 were modified by CAPE, and the inhibitory effects of CAPE and DBL on the p65 phosphorylation and nitrite production were reversed by pretreatment with thiol-containing reagents. 3,4-dihydroxybenzalacetone 99-102 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 110-113 29743292-6 2018 Mechanistic studies showed that IL-9 was indispensable for Tc9 cell persistence and antitumor effects, and cholesterol or its derivatives inhibited IL-9 expression by activating liver X receptors (LXRs), leading to LXR Sumoylation and reduced p65 binding to Il9 promoter. Cholesterol 107-118 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 243-246 29620183-11 2018 Mechanism analysis demonstrated that treatment with puerarin effectively inhibited nuclear factor (NF)-kappaB activity and its target protein levels p65, inhibitor of NF-kappaB kinase subunit beta and inhibitor of NF-kappaB kinase subunit alpha in vascular endothelial cells. puerarin 52-60 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 149-152 29518397-7 2018 In addition, vincristine injection induced the phosphorylation of NFkappaB by activating p65/RelA. Vincristine 13-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 89-92 29518397-7 2018 In addition, vincristine injection induced the phosphorylation of NFkappaB by activating p65/RelA. Vincristine 13-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 93-97 29773986-10 2018 Finally, we determined that flavopiridol suppressed RANKL signaling pathway via inhibition of p65 phosphorylation and nuclear translocation of NF-kappaB. alvocidib 28-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 94-97 29518397-8 2018 To confirm these results, we demonstrated that l-CDL controlled astrocytic-released CXCL1 by inhibiting p65/RelA activation, thus acting on the CXCR2 receptor in the spinal cord. l-cdl 47-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 104-107 29518397-8 2018 To confirm these results, we demonstrated that l-CDL controlled astrocytic-released CXCL1 by inhibiting p65/RelA activation, thus acting on the CXCR2 receptor in the spinal cord. l-cdl 47-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 108-112 29518397-9 2018 In cultured astrocytes, TNF-alpha elicited marked release of the chemokine CXCL1; moreover, the release was blocked by NFkappaB p65 small interfering RNA, NFkappaB inhibitor, and was dose-dependently decreased by l-CDL. l-cdl 213-218 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-131 29525603-0 2018 Melatonin suppresses thyroid cancer growth and overcomes radioresistance via inhibition of p65 phosphorylation and induction of ROS. Melatonin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-94 29525603-3 2018 In this study, we found that melatonin showed potent suppressive roles on NF-kappaB signaling via inhibition of p65 phosphorylation and generated redox stress in thyroid cancer including the anaplastic subtypes. Melatonin 29-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 112-115 29525603-5 2018 By contrast, irradiation of thyroid cancer cells resulted in elevated level of phosphorylated p65, which could be reversed by cotreatment with melatonin. Melatonin 143-152 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 94-97 29525603-7 2018 Taken together, our results suggest that melatonin may exert anti-tumor activities against thyroid carcinoma by inhibition of p65 phosphorylation and induction of reactive oxygen species. Melatonin 41-50 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 126-129 29618597-10 2018 Treatment with MR409 induced elevated cytosolic cAMP and its target, protein kinase A which in turn blocked nicotinamide adenine dinucleotide phosphate oxidase activity and reduced production of reactive oxygen species, thus blocking the phosphorylation of nuclear factor kappaB (p65), a key intermediate in the ligand of receptor activator for nuclear factor-kappa B-Runx2/alkaline phosphatase osteogenesis program. Cyclic AMP 48-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 280-283 29548997-10 2018 Finally, FTY720 significantly inhibited activation of PI3K/Akt/GSK3beta/p65 signaling, which further reduced the expression levels of adhesion molecules in bEND.3 cells treated with B6.MRL-lpr mouse serum. Fingolimod Hydrochloride 9-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 29512021-11 2018 We also determined that metformin exposure leads to increased production of collagen I-III and decreased activation of NF-kB(p65) activity. Metformin 24-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 125-128 29512021-12 2018 The data are consistent with the observation that metformin has a protective effect in this in vitro model of aging 3T3 fibroblasts under high glucose conditions inducing cell proliferation, collagen I and III production, protection from apoptosis, and reducing NF-kB(p65) activity. Metformin 50-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 268-271 29589006-7 2018 In addition, DHQ reduced phosphorylation of NF-kB/p65, and inhibited the expressions of pro-apoptotic factors (p53 and Bax), while it up-regulated the expression of the anti-apoptotic factor Bcl-2. taxifolin 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 50-53 29541735-11 2018 In addition, QA inhibited apoptosis and inflammation via inhibition of NF-kB p65 translocation, C3 activation, and PARP cleavage. quinovic acid 13-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-80 29849710-11 2018 Furthermore, berberine hydrochloride suppressed LPS-induced TLR4 and NF-kappaB p65 activation and the phosphorylation of I-kappaB. berberine chloride 13-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 79-82 29669582-8 2018 Furthermore, NF-kappaB p65 levels in microglial cells and hippocampal neurons were examined in response to LPS and galantamine. Galantamine 115-126 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 23-26 29669582-10 2018 Galantamine decreased the expression of microglia and astrocyte markers (CD11b and GFAP), pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha), and NF-kappaB p65 in the hippocampus of LPS-exposed mice. Galantamine 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 164-167 29849865-10 2018 Additionally, Pin1 protein expression and activity, p66Shc mitochondrial translocation, and NF-kappaB p65 in high glucose-cultured HUVECs were also inhibited by VDR agonist and Juglone. Glucose 114-121 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-105 29555853-4 2018 Wild-type p65 or p65DeltaSE both rescue NF-kappaB-dependent gene expression in p65-deficient murine hippocampal neurons responding to diffuse (PMA/ionomycin) stimulation. Tetradecanoylphorbol Acetate 143-146 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 10-13 29555853-4 2018 Wild-type p65 or p65DeltaSE both rescue NF-kappaB-dependent gene expression in p65-deficient murine hippocampal neurons responding to diffuse (PMA/ionomycin) stimulation. Tetradecanoylphorbol Acetate 143-146 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 17-20 29555853-4 2018 Wild-type p65 or p65DeltaSE both rescue NF-kappaB-dependent gene expression in p65-deficient murine hippocampal neurons responding to diffuse (PMA/ionomycin) stimulation. Tetradecanoylphorbol Acetate 143-146 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 17-20 29555853-4 2018 Wild-type p65 or p65DeltaSE both rescue NF-kappaB-dependent gene expression in p65-deficient murine hippocampal neurons responding to diffuse (PMA/ionomycin) stimulation. Ionomycin 147-156 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 10-13 29555853-4 2018 Wild-type p65 or p65DeltaSE both rescue NF-kappaB-dependent gene expression in p65-deficient murine hippocampal neurons responding to diffuse (PMA/ionomycin) stimulation. Ionomycin 147-156 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 17-20 29555853-4 2018 Wild-type p65 or p65DeltaSE both rescue NF-kappaB-dependent gene expression in p65-deficient murine hippocampal neurons responding to diffuse (PMA/ionomycin) stimulation. Ionomycin 147-156 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 17-20 29533613-8 2018 Application of PA induced cell suppression of LPS-induced expressions of genes and proteins of pro-inflammatory cytokines and induced activation of c-Jun N-terminal kinases (JNKs, p54 and p46; P < 0.05) but not nuclear factor-kappaB p65. perillaldehyde 15-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 236-239 29686615-6 2018 Furthermore, LC53 decreased the phosphorylation of p65, expression of HSP90, Bax, and cleaved-caspase-3 in EIU. lc53 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 29335220-4 2018 In turn, excessive ROS induced caspase-3-dependent PKCdelta activation and stimulated NF-kappaB p65 nuclear translocation, resulting in inflammation in the mouse hippocampus. ros 19-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-99 29627390-8 2018 SB inhibited the LPS-induced phosphorylation of the NF-kappaB p65 and AKT signaling pathways, but failed to inhibit the phosphorylation of the MAPK signaling pathway. Butyric Acid 0-2 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 62-65 29453896-2 2018 In the present study, we found that the widely used antimalarial drug mefloquine was a NF-kappaB inhibitor that blocked the activation of IkappaBalpha kinase, leading to reduction of IkappaBalpha degradation, decrease of p65 phosphorylation, and suppressed expression of NF-kappaB target genes in CRC cells. Mefloquine 70-80 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 221-224 29453896-3 2018 We also found that mefloquine induced growth arrest and apoptosis of CRC cells harboring phosphorylated p65 in culture and in mice. Mefloquine 19-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 104-107 29627390-9 2018 Our data indicated that SB ameliorated the TNBS-induced inflammatory response and intestinal epithelium barrier dysfunction through activating GPR109A and inhibiting the AKT and NF-kappaB p65 signaling pathways. Butyric Acid 24-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 188-191 29627390-9 2018 Our data indicated that SB ameliorated the TNBS-induced inflammatory response and intestinal epithelium barrier dysfunction through activating GPR109A and inhibiting the AKT and NF-kappaB p65 signaling pathways. Trinitrobenzenesulfonic Acid 43-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 188-191 29475099-9 2018 Furthermore, western blot analysis revealed that CX-10 treatment reduced the expression of nuclear factor-kappaB (NF-kappaB) p65 and p-IkappaBalpha, increased the expression of IkappaBalpha and down-regulated the phosphorylation of p38 mitogen-activated protein kinase (MAPK), ERK and JNK. cx-10 49-54 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 125-128 29044685-8 2018 CPA markedly increased phosphorylated NF-kappaB p65 levels in the bladder, an effect that was prevented by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor. Cyclophosphamide 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 48-51 29044685-8 2018 CPA markedly increased phosphorylated NF-kappaB p65 levels in the bladder, an effect that was prevented by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor. pyrrolidine dithiocarbamic acid 107-134 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 48-51 29044685-8 2018 CPA markedly increased phosphorylated NF-kappaB p65 levels in the bladder, an effect that was prevented by pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor. pyrrolidine dithiocarbamic acid 136-140 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 48-51 29482156-11 2018 In addition, we also found that berberine activated AKT1/SOCS1 signaling pathway but inhibited p65 phosphorylation in macrophages in vivo. Berberine 32-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-98 29091322-0 2018 A Novel Diterpenoid Suppresses Osteoclastogenesis and Promotes Osteogenesis by Inhibiting Ifrd1-Mediated and IkappaBalpha-Mediated p65 Nuclear Translocation. Diterpenes 8-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 131-134 29253574-8 2018 Meanwhile, metformin notably suppressed the activation of P65 NF-kappaB, mTOR and S6K, reduced Bace1 protein expression. Metformin 11-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 58-71 28933025-5 2018 Regarding the mechanisms of collagen I-stimulated 3T3-L1 migration, we found that NF-kappaB p65 is activated, including the increased nuclear translocation of NF-kappaB p65 as well as the upregulation of NF-kappaB p65 phosphorylation and acetylation, accompanied by the increased expressions of proinflammatory factors and the generation of reactive oxygen species (ROS). Reactive Oxygen Species 341-364 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 92-95 28933025-5 2018 Regarding the mechanisms of collagen I-stimulated 3T3-L1 migration, we found that NF-kappaB p65 is activated, including the increased nuclear translocation of NF-kappaB p65 as well as the upregulation of NF-kappaB p65 phosphorylation and acetylation, accompanied by the increased expressions of proinflammatory factors and the generation of reactive oxygen species (ROS). Reactive Oxygen Species 366-369 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 92-95 28933025-6 2018 Reduction of collagen I-enhanced migration of cells by treatment with silibinin was associated with suppression of NF-kappaB p65 activity and ROS generation, and negatively correlated with the increasing sirt1 expression. Silybin 70-79 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 125-128 28933025-7 2018 Taken together, the enhanced migration of 3T3-L1 cells induced on collagen I-coated dish is mediated by the activation of NF-kappaB p65 function and ROS generation that can be alleviated with silibinin by upregulation of sirt1, leading to the repression of NF-kappaB p65 function and ROS generation. Silybin 192-201 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 132-135 28933025-7 2018 Taken together, the enhanced migration of 3T3-L1 cells induced on collagen I-coated dish is mediated by the activation of NF-kappaB p65 function and ROS generation that can be alleviated with silibinin by upregulation of sirt1, leading to the repression of NF-kappaB p65 function and ROS generation. Silybin 192-201 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 267-270 29589594-5 2018 Mercaptoethanol treatment reduced the expression levels of NFE2L2, NF-kappaB, p65, TNF-alpha, IL-1beta and increased the expression levels of SOD1, MMP9, and GCLC. Mercaptoethanol 0-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 78-81 29571298-6 2018 The protein levels of phospho-NF-kappaB p65, IKKbeta, and p-IkappaBalpha both in the cytoplasm and nucleus of cocaine-induced CPP mice were detected by Western blot. Cocaine 110-117 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-43 29571298-9 2018 Finally, we found that TLR3 inhibitor reverted cocaine-induced upregulation of phospho-NF-kappaB p65, IKKbeta, and p-IkappaBalpha. Cocaine 47-54 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 97-100 29253574-9 2018 Our data suggest that metformin can exert functional recovery of memory deficits and neuroprotective effect on APP/PS1 mice via triggering neurogenesis and anti-inflammation mediated by regulating AMPK/mTOR/S6K/Bace1 and AMPK/P65 NF-kappaB signaling pathways in the hippocampus, which may contribute to improvement in neurological deficits. Metformin 22-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 226-239 29126931-10 2018 Taken together, our findings suggest that allylguaiacol exerts a neuroprotective effect through the antioxidant activation and protein regulation of NF-kappaB p65 and DAXX-related signaling. Eugenol 42-55 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 159-162 29129634-5 2018 The luciferase activity of cells pretreated with beta-chitosan sulfate further confirmed the nuclear translocation of p50/p65 and c-Fos/c-Jun. beta-chitosan sulfate 49-70 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-125 29214686-8 2018 Myricetin could inhibit the nuclear translocation of p65, degradation of IkappaBalpha, and cellular apoptosis in vivo and in vitro. myricetin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 29367091-9 2018 Our data revealed that LPS induced the up-regulation of TNF-alpha, IL-1beta, iNOS and NF-kappaB p65, the down-regulation of PPAR-gamma were substantially suppressed by chrysophanol in RAW264.7 cells. chrysophanic acid 168-180 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-99 29872577-7 2018 Notably, one major role of cell-intrinsic NF-kappaB RelA is to drive TAMs to suppress CTLs for tumor promotion. tams 69-73 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 52-56 29229533-11 2018 Western blotting results showed that xanthoceraside reduced iNOS and COX-2 protein levels in hippocampus; xanthoceraside also inhibited translocation of NF-kappaB p50 and p65 into the nucleus and phosphorylation of extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38. xanthoceraside 37-51 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 171-174 29354820-5 2018 In addition, asiatic acid enhanced Sirt1 expression, reduced NF-kappaB p65 acetylation, and suppressed NF-kappaB activation after LPS stimulation. asiatic acid 13-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 71-74 29926670-10 2018 Compared with ethanol group, addition of CQ increased furtherthe level of LC3-IIexpression, and TG amount, serum AST and ALT activities, and the expression of NF-kappaB p65, TNF-alphaand IL-6. Chloroquine 41-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 169-172 29229533-11 2018 Western blotting results showed that xanthoceraside reduced iNOS and COX-2 protein levels in hippocampus; xanthoceraside also inhibited translocation of NF-kappaB p50 and p65 into the nucleus and phosphorylation of extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38. xanthoceraside 106-120 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 171-174 29737211-9 2018 Furthermore, wedelolactone suppressed the activity of nuclear factor-kappa B (NF-[Formula: see text]B), a critical transcriptional factor of the above-mentioned inflammatory cytokines by limiting the phosphorylation of I kappa B alpha (I[Formula: see text]B[Formula: see text] and p65. wedelolactone 13-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 281-284 29268191-9 2018 Mechanistically, we found that montelukast suppressed LPS-induced nuclear translocation of NF-kappaB p65 as well as NF-kappaB transcriptional activity by inhibiting the phosphorylation and degradation of IkappaBalpha. montelukast 31-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 29034440-10 2018 Curcumin decreased risperidone-induced increases in serum markers of hepatotoxicity (ALAT, ASAT), as well as of one major hepatic pro-inflammatory transcription factor (NFkappaB: p105 mRNA and p65 protein). Curcumin 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 193-196 29034440-10 2018 Curcumin decreased risperidone-induced increases in serum markers of hepatotoxicity (ALAT, ASAT), as well as of one major hepatic pro-inflammatory transcription factor (NFkappaB: p105 mRNA and p65 protein). Risperidone 19-30 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 193-196 29284118-4 2018 We demonstrate here that DANFIN (N,N"-bis-(2,4-dimethyl-phenyl)-ethane-1,2-diamine) functions as an inhibitor of the p65 family proteins and induces chemosensitization to bortezomib in multiple myeloma. N,N'-bis-(2,4-dimethyl-phenyl)-ethane-1,2-diamine 25-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-120 29284118-4 2018 We demonstrate here that DANFIN (N,N"-bis-(2,4-dimethyl-phenyl)-ethane-1,2-diamine) functions as an inhibitor of the p65 family proteins and induces chemosensitization to bortezomib in multiple myeloma. N,N'-bis-(2,4-dimethyl-phenyl)-ethane-1,2-diamine 33-82 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-120 29284118-4 2018 We demonstrate here that DANFIN (N,N"-bis-(2,4-dimethyl-phenyl)-ethane-1,2-diamine) functions as an inhibitor of the p65 family proteins and induces chemosensitization to bortezomib in multiple myeloma. Bortezomib 171-181 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-120 29284118-5 2018 DANFIN was found to be an inhibitor of interactions between p65 and IkappaBalpha without the inhibition of the DNA binding activity of the p65 protein. N,N'-bis-(2,4-dimethyl-phenyl)-ethane-1,2-diamine 0-6 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 60-63 29284118-6 2018 In addition, DANFIN affected the IkappaBalpha binding region in Rel Homology Domain (RHD) and suppressed the nuclear translocalization of the p65 protein in cells. N,N'-bis-(2,4-dimethyl-phenyl)-ethane-1,2-diamine 13-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 142-145 29329581-15 2018 In addition, exogenous delivery of miR-124 could suppress MEKK3 and p-p65 expression and attenuate the activation of microglia in the substantia nigra pars compacta of MPTP-treated mice. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 168-172 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 29316653-5 2018 Resveratrol and valproate restored the acetylation of histone H3 (K9/18), and they reduced the RelA(K310) acetylation and the Bim level in neurons exposed to OGD. Valproic Acid 16-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-99 29113806-5 2018 Besides, Cynatratoside-C blocked the expression of Toll-like receptor 4 (TLR4) and then suppressed the phosphorylation of nuclear transcription factor-kappa B (NF-kappaB) p65 and degradation inhibitor of NF-kappaBalpha (IkappaBalpha). cynatratoside-C 9-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 171-174 29199487-8 2018 The chalcone suppressed nuclear factor-kappaB (NF-kappaB) stimulation by preventing activation of inhibitor kappaB kinase (IKK) alpha/beta, degradation of inhibitor kappaB (IkappaB) alpha, and translocation of p65 NF-kappaB into the nucleus. Chalcone 4-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 210-223 28942135-6 2018 RESULTS: Capnoidine-treated mice had significantly: a) improved clinical symptoms (body weight loss, mobility, piloerection and faecal consistency); b) reduced colon pathology (adhesion, oedema, ulceration, and colon length); c) altered inflammatory cytokines profiles within the colons; d) reduced levels of p-IkappaB-alpha (Ser32) and p-NF-kappaB p65 (Ser536) and e) reduced histological inflammation in the colon when compared with mice administered TNBS only. Capnoidine 9-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 349-352 29329563-7 2018 O-PMs also induced the phosphorylation of AKT, p65, and STAT3. o-pms 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 47-50 29316653-1 2018 Histone deacetylation, together with altered acetylation of NF-kappaB/RelA, encompassing the K310 residue acetylation, occur during brain ischemia. L-arabinitol 93-97 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-74 29929190-15 2018 TUNEL staining, caspase-3, and caspase-9 activity assays consistently revealed that alcohol-induced microglial apoptosis was inhibited by depletion of p65. Alcohols 84-91 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 151-154 29793330-8 2018 In addition, we further explored the potential mechanism of baicalin treatment on AS, and found that baicalin treatment attenuated the high phosphorylation levels of JNK, p65, p-38 and ERK1/2 induced by AS, indicating that baicalin treatment inhibited the NF-kappaB and p38 MAPK signaling pathways in AS. baicalin 101-109 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 171-174 29793330-8 2018 In addition, we further explored the potential mechanism of baicalin treatment on AS, and found that baicalin treatment attenuated the high phosphorylation levels of JNK, p65, p-38 and ERK1/2 induced by AS, indicating that baicalin treatment inhibited the NF-kappaB and p38 MAPK signaling pathways in AS. baicalin 101-109 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 171-174 29399089-8 2018 GA-A treatment reduced LPS-induced expression of nuclear factor (NF)-kappaB (p65) and its inhibitor, demonstrating that non-toxic suppression of IL-1beta, IL-6 and TNF-alpha production by GA-A is, at least in part, due to suppression of the NF-kappaB signaling pathway. ganoderic acid A 188-192 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-80 29486473-12 2018 Nuclear translocation of NFkappaB/p65 was detected in PA-treated cells, which was prevented by SF preparation. Palmitic Acid 54-56 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 34-37 29484117-5 2018 Herein, we demonstrated that paeoniflorin has a dose-dependent suppressive action on RANKL-evoked osteoclast differentiation and bone resorption, achieved by inhibiting the NF-kappaB pathway and subunit p65 nuclear translocation. peoniflorin 29-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 203-206 29399089-8 2018 GA-A treatment reduced LPS-induced expression of nuclear factor (NF)-kappaB (p65) and its inhibitor, demonstrating that non-toxic suppression of IL-1beta, IL-6 and TNF-alpha production by GA-A is, at least in part, due to suppression of the NF-kappaB signaling pathway. ganoderic acid A 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-80 29484117-7 2018 At the molecular level, paeoniflorin was found to inhibit NF-kappaB transcriptional activity and stimulate osteoblastogenesis-related marker gene expression (ALP, osteocalcin, OPN and Runx2), a trend that was inhibited by p65 overexpression. peoniflorin 24-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 222-225 28643395-9 2017 In addition, high-glucose-induced activation of autophagic flux and apoptosis were largely attenuated by p65 siRNA, suggesting that catalase ameliorates diabetes-induced autophagy, at least in part by increasing the activity of the NF-kappaB pathway and p65-mediated transcription of BECN1. Glucose 18-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 105-108 29021196-5 2017 NF-kappaB inhibition with QNZ, caffeic acid phenethyl ester, or small interfering RNA (siRNA)-mediated silencing of NF-kappaB p65 attenuated high-NaCl-induced PRR upregulation. Sodium Chloride 146-150 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 126-129 29021196-7 2017 High-NaCl-induced apoptosis was attenuated by a PRR decoy inhibitor, PRO20, or siRNA-mediated silencing of NF-kappaB p65. Sodium Chloride 5-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-120 28464271-7 2017 Moreover, picroside II markedly decreased the phosphorylation of p38, ERK, JNK, p65, and I-kappaB degradation, and significantly suppressed c-Fos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), both the key transcription factors during osteoclastogenesis. picroside II 10-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 80-83 28643395-9 2017 In addition, high-glucose-induced activation of autophagic flux and apoptosis were largely attenuated by p65 siRNA, suggesting that catalase ameliorates diabetes-induced autophagy, at least in part by increasing the activity of the NF-kappaB pathway and p65-mediated transcription of BECN1. Glucose 18-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 254-257 28983590-10 2017 Nuclear translocation of p65 was significantly inhibited by I-BET151 at all concentrations. GSK1210151A 60-68 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 25-28 29055190-9 2017 Moreover, pinocembrin treatment suppressed phosphorylation of inhibitor-kappaBalpha (IkappaBalpha) and NF-kappaB subunit p65 activation in lung tissue of OVA-sensitized mice. pinocembrin 10-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-124 28865949-2 2017 We previously demonstrated that valproic acid (VPA) exposure in utero decreases total cellular protein expression of the NF-kappaB subunit p65 in CD-1 mouse embryos with a neural tube defect but not in phenotypically normal littermates. Valproic Acid 32-45 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 139-142 29182579-6 2017 Krill oil also suppresses IkappaB degradation as well as p50 and p65 translocation into the nuclei of LPS-injected mice brain cells. krill oil 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 65-68 29243967-4 2017 We found that P. tenera extract regulates the NF-kappaB IkappaB kinase (IKK) signaling pathway, and we assessed the expression and translocation of p65, a subunit of NF-kappaB, in RAW264.7 mouse macrophage cells after treatment with PTE. pte 233-236 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 148-151 29383139-8 2017 DHA can also reduce expression levels of PI3-kinase (PI3K), p-PI3K, protein kinase B (AKT), p-AKT, nuclear factor (NF)-kappaB/p65, and p-NF-kappaB/p65. artenimol 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 126-129 29383139-8 2017 DHA can also reduce expression levels of PI3-kinase (PI3K), p-PI3K, protein kinase B (AKT), p-AKT, nuclear factor (NF)-kappaB/p65, and p-NF-kappaB/p65. artenimol 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 147-150 29044882-6 2017 Furthermore, Sox2-overexpression tumor cells activated NF-kappaB-CCL1 signaling to recruit Tregs through reducing the binding of H3K27Me3 on promoter regions of p65 and Ccl1. tregs 91-96 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 161-164 28865949-2 2017 We previously demonstrated that valproic acid (VPA) exposure in utero decreases total cellular protein expression of the NF-kappaB subunit p65 in CD-1 mouse embryos with a neural tube defect but not in phenotypically normal littermates. Valproic Acid 47-50 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 139-142 29166707-27 2017 Results: (1) The mRNA expression of NF-kappaB-p65 of cells in Cy3-si435 group was 0.183+-0.004, significantly lower than 1.003+-0.092 in Cy3-siNC group (t=15.46, P<0.01). cy3 62-65 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 46-49 29166707-27 2017 Results: (1) The mRNA expression of NF-kappaB-p65 of cells in Cy3-si435 group was 0.183+-0.004, significantly lower than 1.003+-0.092 in Cy3-siNC group (t=15.46, P<0.01). si435 66-71 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 46-49 29166707-27 2017 Results: (1) The mRNA expression of NF-kappaB-p65 of cells in Cy3-si435 group was 0.183+-0.004, significantly lower than 1.003+-0.092 in Cy3-siNC group (t=15.46, P<0.01). cy3-sinc 137-145 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 46-49 29201175-10 2017 The results demonstrated that Fag inhibited the production of proinflammatory cytokines via inhibiting NF-kappaB p65 nuclear translocation and IkappaB phosphorylation (P<0.05). fagomine 30-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 113-116 29166707-31 2017 (5) The mRNA expression of NF-kappaB-p65 of cells in Cy3-si435-PAC group was 0.286+-0.015, significantly lower than 1.002+-0.073 in Cy3-siNC-PAC group (t=16.62, P<0.01). cy3 53-56 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 37-40 29166707-31 2017 (5) The mRNA expression of NF-kappaB-p65 of cells in Cy3-si435-PAC group was 0.286+-0.015, significantly lower than 1.002+-0.073 in Cy3-siNC-PAC group (t=16.62, P<0.01). si435-pac 57-66 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 37-40 29166707-31 2017 (5) The mRNA expression of NF-kappaB-p65 of cells in Cy3-si435-PAC group was 0.286+-0.015, significantly lower than 1.002+-0.073 in Cy3-siNC-PAC group (t=16.62, P<0.01). cy3-sinc-pac 132-144 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 37-40 29166707-37 2017 Cy3-si435-PAC nanoparticles can be effectively uptaked by HL-1 cells and suppress NF-kappaB-p65 mRNA expression. cy3 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 92-95 29166707-37 2017 Cy3-si435-PAC nanoparticles can be effectively uptaked by HL-1 cells and suppress NF-kappaB-p65 mRNA expression. si435 4-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 92-95 29166707-37 2017 Cy3-si435-PAC nanoparticles can be effectively uptaked by HL-1 cells and suppress NF-kappaB-p65 mRNA expression. pac 10-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 92-95 28821450-10 2017 Notably, hypoxia resulted in a significant nuclear translocation of NF-kappaB p65, which was inhibited by administration of carvedilol. Carvedilol 124-134 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 78-81 28888780-8 2017 Further mechanistic studies revealed that BBR-induced inhibition of NF-kappaB is Sirt1-dependent, as either pharmacologically or genetically inactivating Sirt1 enhanced the IkappaBetaalpha degradation, IKK phosphorylation, NF-kappaB p65 acetylation and DNA-binding activity. Berberine 42-45 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 233-236 28892788-9 2017 By western blot analysis we found that triptolide impeded phosphorylation of NF-kappaB p65 subunit and extracellular signal-regulated kinase (ERK), along with reduction of cyclin D1, without any impact on other NF-kappaB related protein expression like total p65, p50, IkappaB-alpha, p-IkappaB-alpha. triptolide 39-49 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 87-90 28892788-9 2017 By western blot analysis we found that triptolide impeded phosphorylation of NF-kappaB p65 subunit and extracellular signal-regulated kinase (ERK), along with reduction of cyclin D1, without any impact on other NF-kappaB related protein expression like total p65, p50, IkappaB-alpha, p-IkappaB-alpha. triptolide 39-49 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 259-262 27796745-6 2017 In addition, PCP treatment significantly upregulated the nuclear translocations of nuclear factor erythroid-2-related factor 2 (Nrf2) and nuclear factor kappa-B (NF-kappaB) p65, as well as their DNA binding activities and gamma-glutamylcysteine (GCL) mRNA expression in WT and non-TG mice. Phencyclidine 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 173-176 28799756-5 2017 Both in vivo and in vitro, CAPE enhanced p-Akt (Ser473) and p-insulin receptor substrate (IRS)-1 (Tyr612), but inhibited p-JNK (Thr183/Tyr185), p-NF-kappaB p65 (Ser536), and nuclear translocation of p-NF-kappaB p65 (Ser536). caffeic acid phenethyl ester 27-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 156-159 28849172-8 2017 Artesunate attenuated TNF-alpha and IL-6 levels, suppressed alpha-SMA, TLR4, MyD88, NF-kappaB p65 and TGF-beta1 protein expression, and decreased caspase-3 activity in nephritis mice. Artesunate 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 94-97 28849173-6 2017 In addition, myricitrin significantly inhibited the TNF-alpha-induced expression of nuclear factor (NF)-kappaB p65, and prevented the TNF-alpha-induced degradation of nuclear factor of kappa light chain enhancer in B-cells inhibitor alpha. myricitrin 13-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 111-114 29271162-7 2017 Moreover, LMSC significantly increased the phosphorylation of IKKbeta, IkappaBalpha, and NF-kappaB p65. lmsc 10-14 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-102 28524642-11 2017 However, PD could inhibit the generation of ROS and NF-kappaB p65 activation, suggesting that PD suppressed LTA-induced injury by attenuating ROS generation and TLR2-NFkappaB signalling. Reactive Oxygen Species 142-145 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 62-65 28799756-5 2017 Both in vivo and in vitro, CAPE enhanced p-Akt (Ser473) and p-insulin receptor substrate (IRS)-1 (Tyr612), but inhibited p-JNK (Thr183/Tyr185), p-NF-kappaB p65 (Ser536), and nuclear translocation of p-NF-kappaB p65 (Ser536). caffeic acid phenethyl ester 27-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 211-214 27374794-8 2017 Moreover, higher expression levels of IL-6, TNF-alpha, p65, CXCL-1 and iNOS, and an increased level of NF-kappaB (p65) nuclear translocation were also found in the DSS-treated BRD7-/- mice. dss 164-167 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 29053632-11 2017 Expression of p65 showed that ZJF dampened nuclear factor-kappaB (NF-kappaB) activation. zjf 30-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 14-17 29026145-8 2017 Experiments using LPS-activated primary macrophages revealed that the anti-inflammatory effects of cibinetide were dependent on CD131 and JAK2 functionality and were mediated via inhibition of NF-kappaB subunit p65 activity. cibinetide 99-109 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 211-214 28867647-8 2017 We also showed that melatonin blocked the phosphorylation of IkappaB-alpha and p65, but not IKKalpha, and significantly inhibited the expression of NFATc1 and c-Fos. Melatonin 20-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 79-82 28818856-7 2017 Tamoxifen administration to Col1a2-CreERT mT/mG mice induced Cre expression and RelA depletion in aortic smooth muscle cells and fibroblasts but not in endothelial cells. Tamoxifen 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 80-84 27374794-8 2017 Moreover, higher expression levels of IL-6, TNF-alpha, p65, CXCL-1 and iNOS, and an increased level of NF-kappaB (p65) nuclear translocation were also found in the DSS-treated BRD7-/- mice. dss 164-167 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-117 28821008-8 2017 We further demonstrated that TC markedly reversed Abeta1-42-induced phosphorylation and degradation of IkappaBalpha, nuclear translocation of p65, and NF-kappaB transcriptional activity. caryophyllene 29-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 142-145 28723419-0 2017 NF-kappaB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFalpha-or diet-induced inflammation. Serine 14-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 10-13 28723419-3 2017 To investigate the control of NF-kappaB activity by phosphorylation of the NF-kappaB p65 subunit, we generated a knock-in mouse model in which serine 467 (the mouse homolog of human p65 serine 468) was replaced with a non-phosphorylatable alanine (S467A). Serine 186-192 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 182-185 28723419-7 2017 Altogether, this study demonstrates that phosphorylation of p65 serine 467 augment NF-kappaB activity and exacerbates various deleterious effects of overnutrition in mice. Serine 64-70 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 60-63 28666365-6 2017 Mechanistic studies showed that chronic Cd treatment suppressed ERK1/2 and NF-kappaB p65 phosphorylation in wounded tissue at early stage after injury. Cadmium 40-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 85-88 28966615-8 2017 Furthermore, in LPS-stimulated mouse mammary epithelial cells (mMECs), LPS increased the expressions of phosphorylated (p)-p65, p-IkappaB proteins, which is attenuated by sodium propionate. sodium propionate 171-188 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 123-126 28960214-6 2017 The upregulation of FcgammaRIIB by resveratrol involved an increase of Sirt1 protein and deacetylation of p65 NF-kappaB (K310). Resveratrol 35-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 106-119 29021784-3 2017 In Pseudomonas aeruginosa this pathway is controlled and coordinated by the activity of the RelA and SpoT enzymes that metabolize the small nucleotide secondary messenger molecule (p)ppGpp. Guanosine Tetraphosphate 183-188 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 92-96 28979674-6 2017 The nuclear localization of NF-kappaB p50/p65 was analyzed after treatment with solasonine. alpha-solamargine 80-90 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 42-45 28979674-11 2017 Besides, solasonine decreased the expression of proinflammatory mediators and nuclear translocalization of NF-kappaB p50/p65. alpha-solamargine 9-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-124 28545897-5 2017 Moreover, resveratrol treatment significantly reduced eosinophil counts, p65, Interferon-gamma, interleukin (IL)-5, IL-33, and tumor necrosis factor-alpha levels, matrix metalloproteinase-9 activity, claudin-5 degradation, and blood-brain barrier permeability. Resveratrol 10-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-76 28566502-8 2017 The present results demonstrate that the treatment of the haplotype Npr1+/- mice with ATRA-NaBu significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC, NF-kappaB (p65), and STAT1. atra-nabu 86-95 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 233-236 28616865-9 2017 Furthermore, isoacteoside attenuated the LPS-induced transcriptional activity of NF-kappaB by decreasing the levels of phosphorylated IkappaB-alpha and IKK and NF-kappaB/p65 nuclear translocation. isoacteoside 13-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 170-173 28444820-5 2017 Western blotting was used to examine the protein expression of B16F10 cells after exposed to casticin and the results showed that casticin decreased the expressions of MMP-9, MMP-2, MMP-1, FAK, 14-3-3, GRB2, Akt, NF-kappaB p65, SOS-1, p-EGFR, p-JNK 1/2, uPA, and Rho A in B16F10 cells. casticin 130-138 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 223-226 28851995-7 2017 Furthermore, melatonin reduced the stress-induced activation of the NF-kappaB signaling pathway by decreasing the phosphorylation of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) and p65 nuclear translocation. Melatonin 13-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 236-239 28634113-8 2017 Compared to the untreated group, DEN/HCB treatment decreased total hepatic glutathione levels and glutathione peroxidase (GSH-Px) activity while increased lipid peroxidation, p65 protein expression, cell proliferation/apoptosis and the PNL development. Diethylnitrosamine 33-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 175-178 28634113-8 2017 Compared to the untreated group, DEN/HCB treatment decreased total hepatic glutathione levels and glutathione peroxidase (GSH-Px) activity while increased lipid peroxidation, p65 protein expression, cell proliferation/apoptosis and the PNL development. Hexachlorobenzene 37-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 175-178 28841192-0 2017 Eicosapentaenoic Acid (EPA) Induced Macrophages Activation through GPR120-Mediated Raf-ERK1/2-IKKbeta-NF-kappaB p65 Signaling Pathways. Eicosapentaenoic Acid 0-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 112-115 28841192-0 2017 Eicosapentaenoic Acid (EPA) Induced Macrophages Activation through GPR120-Mediated Raf-ERK1/2-IKKbeta-NF-kappaB p65 Signaling Pathways. Eicosapentaenoic Acid 23-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 112-115 28841192-7 2017 Conclusions: EPA (0.6-3.0 mumol) activates RAW264.7 cells through GPR120-mediated Raf-ERK1/2-IKKbeta-NF-kappaB p65 signaling pathways. Eicosapentaenoic Acid 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 111-114 28712788-8 2017 As a contrast, the specific inhibitor of NF-kappaB pyrrolidine dithiocarbamate (PDTC) achieved similar repressive effects as ARS on phosphorylation of p65 and IkappaBalpha, and serum levels of aminotransferases. pyrrolidine dithiocarbamic acid 51-78 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 151-154 28712788-8 2017 As a contrast, the specific inhibitor of NF-kappaB pyrrolidine dithiocarbamate (PDTC) achieved similar repressive effects as ARS on phosphorylation of p65 and IkappaBalpha, and serum levels of aminotransferases. pyrrolidine dithiocarbamic acid 80-84 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 151-154 28637784-8 2017 Stat3 acetylation at lysine 370 or lysine 383 played a key role in the ability of Stat3 to form a supercomplex with RelA. Lysine 21-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 116-120 29088843-11 2017 Signaling pathway analysis demonstrated that the phosphorylation of NF-kappaB p65 but not ERK1/2 in DCs was inhibited after the treatment of immethridine. Immethridine 141-153 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 78-81 28637784-8 2017 Stat3 acetylation at lysine 370 or lysine 383 played a key role in the ability of Stat3 to form a supercomplex with RelA. Lysine 35-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 116-120 28779128-3 2017 Furthermore, silencing of P65 attenuated macrophage apoptosis and the upregulation of Fas caused by ox-LDL, whereas P65 expression was not significantly affected by treatment with Fas siRNA. ammonium ferrous sulfate 86-89 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 26-29 28779128-5 2017 Additionally, D4F inhibited ox-LDL-induced P65 nuclear translocation and upregulation of Fas/FasL pathway-related proteins in RAW264.7 cells and in atherosclerotic lesions of apoE-/- mice. D4F 14-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 43-46 28810543-10 2017 Atorvastatin treatment led to downregulation of tTG and TREM-1 expression in lung tissue after ovalbumin sensitization, blocked the activity of MMP-9, vascular endothelial growth factor, nuclear factor-kappaB p65, alpha-SMA, HIF-alpha and TGF-beta1 and up-regulated Nrf2 expression. Atorvastatin 0-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 209-212 28938606-9 2017 Furthermore, the reduction of NLRP3 protein expression by oroxylin A was dependent on the inhibition of NF-kappaB p65 expression and nuclear translocation. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 58-68 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-117 28365871-8 2017 In addition, western blot results showed that cavidine inhibited the phosphorylation of nuclear factor-kappaB (NF-kappaB) p65 and IkappaBalpha induced by LPS. cavidine 46-54 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-125 29179451-12 2017 Moreover, dopamine markedly down-regulated inflammation-related protein expression levels and p50/p65 NF-kappaB nuclear localization in tumor cells, thereby inhibiting increases in tumor weight and size in xenograft mice. Dopamine 10-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 98-101 28600438-6 2017 Rela+/- mice have similarly impaired NF-kappaB activation, develop cutaneous ulceration from TNF exposure, and exhibit severe dextran sodium sulfate-induced colitis, ameliorated by TNF inhibition. dextran sodium sulfate 126-148 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 0-4 28654831-6 2017 The RAW 264.7 cells treated with kappa-carrageenan polysaccharide show upregulated TLR4 expression, and the main subunit of NF-kappaB (p65) is translocated. kappa-carrageenan polysaccharide 33-65 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 135-138 28954469-6 2017 L-arginine was able to elicit NF-kappaB signaling through the increase of p65 active subunit level (p<0.004), while CD26 surface antigen level was not significantly changed. Arginine 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-77 28626608-6 2017 Upon stimulation with an oxidized phospholipid as pro-inflammatory agent, c-Kit deficient SMC displayed enhanced NF-kappaB transcriptional activity, higher phosphorylated/total p65 ratio, and increased protein expression of NF-kappaB regulated pro-inflammatory mediators with respect to cells from control mice. Phospholipids 34-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 177-180 28504466-12 2017 Furthermore, NTB suppressed LPS-stimulated NF-kappaB/p65 phosphorylation and nuclear translocation. nepetoidin B 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 28507170-6 2017 Leptomycin B, a nuclear export inhibitor, blocked p65 nuclear export and inhibited the anti-inflammatory action of PPARgamma. leptomycin B 0-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 50-53 28318634-6 2017 Further studies found that increased Sp1 and NFkappaB-p65 interacted in the nucleus of podocytes incubated with high glucose, and Sp1 bound to the Dnmt1 promoter region. Glucose 117-124 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 54-57 28318634-7 2017 The involvement of the Sp1/NFkappaB-p65 complex in Dnmt1 regulation was confirmed by the observation that Sp1 knockdown using mithramycin A or siRNA decreased Dnmt1 protein levels. mithramycin A 126-139 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 36-39 28655324-11 2017 Interestingly, treatment with JO alone did not affect the activity of nuclear factor (NF)kappaB/RelA in the skin, but combined treatment of LTAP-JO blocked DCNB-mediated NFkappaB/RelA activation. 1,2-dichloro-4-nitrobenzene 156-160 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 179-183 28603455-9 2017 In isolated microglia, TMP attenuated the effects of lipopolysaccharide on the phosphorylation of cytoplasmic IKKalpha/beta and IKB-alpha, and levels of nucleic p65. tetramethylpyrazine 23-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 161-164 28144780-9 2017 The expression of ICAM-1 and NF-kappaB p65 was also reduced after sivelestat administration. sivelestat 66-76 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 39-42 28391962-8 2017 We show that these improvements are mediated through SU9516 inhibitory actions on the p65-NF-kappaB pro-inflammatory and Ste20-related proline alanine rich kinase (SPAK)/OSR1 signaling pathways. SU 9516 53-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 86-99 28389348-9 2017 From the results of western blotting, resveratrol suppressed the expression of phosphorylation of p65 and IkappaB from NF-kappaB signal pathway and phosphorylation of p38 and ERK from MAPK signal pathway. Resveratrol 38-49 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 98-101 28494015-10 2017 Furthermore, overexpression of Lethe in RAW cells treated with high glucose significantly reduced the translocation of p65-NFkB to the nucleus, which resulted in decreased NOX2 expression and ROS production. Glucose 68-75 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-122 28487944-9 2017 After 3 or 7 days of treatment, Disease Activity Index (DAI) as well as histological scores and NF-kappaB p65 protein expression were significantly reduced in mice treated with bortezomib at a dose of 0.6 or 1 mg/kg/day. Bortezomib 177-187 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 106-109 28451684-5 2017 Furthermore, EN supplemented with CPs diminished the phosphorylation of intestinal NF-kappaB p65 and simultaneously down-regulated the mRNA expression of TNF-alpha and IL-6 in small intestine (p < 0.05 vs. BE). cps 34-37 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 93-96 28542400-9 2017 CoCl2 (500mumol/L, 8h) treatment increased intracellular Ca2+ level, and caused the phosphorylation of CAMKIIalpha, ERK1/2 and NFkappaB (p65), as well as the activation of caspase 3. cobaltous chloride 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 137-140 28542400-9 2017 CoCl2 (500mumol/L, 8h) treatment increased intracellular Ca2+ level, and caused the phosphorylation of CAMKIIalpha, ERK1/2 and NFkappaB (p65), as well as the activation of caspase 3. 8h 19-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 137-140 28494015-10 2017 Furthermore, overexpression of Lethe in RAW cells treated with high glucose significantly reduced the translocation of p65-NFkB to the nucleus, which resulted in decreased NOX2 expression and ROS production. Reactive Oxygen Species 192-195 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-122 28148567-5 2017 Under hyperglycemia, cAMP production and PKA activity were markedly increased as a result of glucose transporter 1-mediated glucose influx that drives glucose metabolism and ATP production, which led to increased phosphorylation of p65 and CREB. Cyclic AMP 21-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 232-235 28254441-7 2017 EPA+DHA also inhibited phosphorylation of the stress-associated transcription factor NF-kappaB subunit p65 at Ser536, which is known to enhance NF-kappaB nuclear translocation and transcriptional activity, including cytokine gene activation. Eicosapentaenoic Acid 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 103-106 28254441-7 2017 EPA+DHA also inhibited phosphorylation of the stress-associated transcription factor NF-kappaB subunit p65 at Ser536, which is known to enhance NF-kappaB nuclear translocation and transcriptional activity, including cytokine gene activation. Docosahexaenoic Acids 4-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 103-106 28430612-4 2017 In addition, diosmetin prevented the expression of phosphorylated IKK, IkappaBalpha, and NF-kappaB p65 in the NF-kappaB signaling pathway, and JNK and p38 in the MAPK signaling pathway. diosmetin 13-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-102 28148567-5 2017 Under hyperglycemia, cAMP production and PKA activity were markedly increased as a result of glucose transporter 1-mediated glucose influx that drives glucose metabolism and ATP production, which led to increased phosphorylation of p65 and CREB. Glucose 93-100 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 232-235 28148567-5 2017 Under hyperglycemia, cAMP production and PKA activity were markedly increased as a result of glucose transporter 1-mediated glucose influx that drives glucose metabolism and ATP production, which led to increased phosphorylation of p65 and CREB. Glucose 124-131 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 232-235 28148567-5 2017 Under hyperglycemia, cAMP production and PKA activity were markedly increased as a result of glucose transporter 1-mediated glucose influx that drives glucose metabolism and ATP production, which led to increased phosphorylation of p65 and CREB. Adenosine Triphosphate 174-177 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 232-235 28238828-22 2017 Pre-treatment with HEDb inhibited this translocation of NF-kappaB p65 (58% at 20microg/mL, p<0.001). hedb 19-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 28447718-7 2017 Acetylation levels of NF-kappaB p65 were decreased in lipopolysaccharide-treated cells and ALF mice, and were promoted by MS275 treatment and HDAC1 silencing. entinostat 122-127 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 32-35 28367982-6 2017 Western blot analysis indicated that okanin suppressed LPS-induced activation of the NF-kappaB signaling pathway by inhibiting the phosphorylation of IkappaBalpha and decreasing the level of nuclear NF-kappaB p65 after LPS treatment. okanin 37-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 209-212 28284330-7 2017 FPS-ZM1 and fasudil exerted their anti-inflammatory effects by downregulating inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), NLRP3 and nuclear translocation of nuclear factor kappa B (NF-kappaB) p65. fasudil 12-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 214-217 28529457-6 2017 Our results suggested that deguelin inhibited NF-kappaB binding activity by enhancing the ability of IkappaBalpha to maintain NF-kappaB in an inactive form in the cytoplasm and preventing the TNF-alpha induced translocation of p65 to the nucleus. deguelin 27-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 227-230 28367982-7 2017 Immunofluorescence staining results showed that okanin inhibited the translocation of the NF-kappaB p65 subunit from the cytosol to the nucleus. okanin 48-54 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 100-103 28338009-6 2017 Resveratrol also decreased TNF-alpha-induced IkappaB phosphorylation and the phosphorylation, acetylation, and translocation of NF-kappaB p65. Resveratrol 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 138-141 28065733-8 2017 We found that CNH treatment decreased APJ but increased Iba-1 proteins expression, as well as nucleus translocation of p50 and p65 in the hippocampus, which were reversed by apelin-13 treatment. 1-hydroxy-11-norcadinan-5-en-4-one 14-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 127-130 28152630-5 2017 Meanwhile, physalin E reduced the degradation of I-kappa B protein in the cytoplasm and downregulated the nuclear factor-kappaB (NF-kappaB) p65 protein in the nuclear, which resulted in the inhibition of the NF-kappaB nuclear translocation. physalin E 11-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 140-143 28157617-6 2017 The antiinflammatory effect of ATRA was associated with a reduction in the phosphorylation levels of IkappaB and p65 (~50%, P<.05), two subunits of the NF-kappaB pathway, probably mediated by PGC1alpha, in 3 T3-L1 adipocytes. Tretinoin 31-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 113-116 28167529-5 2017 The IL-8/CXCL8 expression induced by vorinostat in EOC cells is dependent on IkappaB kinase (IKK) activity and associated with a gene-specific recruitment of IKKbeta and IKK-dependent recruitment of p65 NFkappaB to the IL-8/CXCL8 promoter. Vorinostat 37-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 199-202 28237703-6 2017 In addition, Ub deficiency led to the nuclear accumulation of the p65 isoform of Nrf1 under As(III) exposure. as(iii) 92-99 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 27806407-2 2017 Furthermore, tangeretin (5, 10, and 20 microM) suppressed the activation and translocation of nuclear factor kappa-B (p65) into the nuclei in vitro by inhibiting the binding of lipopolysaccharide on dendritic cells. tangeretin 13-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-121 28223539-10 2017 Furthermore, H2O2 treatment increased the phosphorylation of p65 and IkappaBalpha, which were decreased when treated with N-acetyl cysteine or thymol. Hydrogen Peroxide 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 61-64 28223539-10 2017 Furthermore, H2O2 treatment increased the phosphorylation of p65 and IkappaBalpha, which were decreased when treated with N-acetyl cysteine or thymol. Acetylcysteine 122-139 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 61-64 28223539-10 2017 Furthermore, H2O2 treatment increased the phosphorylation of p65 and IkappaBalpha, which were decreased when treated with N-acetyl cysteine or thymol. Thymol 143-149 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 61-64 27865009-7 2017 Melatonin in combination with 5-FU markedly suppressed the phosphorylation of PI3K, AKT, IKKalpha, IkappaBalpha, and p65 proteins, promoted the translocation of NF-kappaB p50/p65 from the nuclei to cytoplasm, abrogated their binding to the iNOS promoter, and thereby enhanced the inhibition of iNOS signaling. Melatonin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-120 28167257-7 2017 Tetradecanol inhibited IkappaBalpha degradation and nuclear translocation of NF-kappaB subunit, p65 in PMA/Io-activated EL-4 T cells. myristyl alcohol 0-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-99 28253885-10 2017 RESULTS: Dh404 significantly attenuated endothelial dysfunction in diabetic Akita mice characterized by reduced contraction in response to phenylephrine and the downregulation of inflammatory genes (VCAM-1, ICAM-1, p65, IL-1beta) and pro-oxidant genes (Nox1 and Nox2). dh404 9-14 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 215-218 27865009-7 2017 Melatonin in combination with 5-FU markedly suppressed the phosphorylation of PI3K, AKT, IKKalpha, IkappaBalpha, and p65 proteins, promoted the translocation of NF-kappaB p50/p65 from the nuclei to cytoplasm, abrogated their binding to the iNOS promoter, and thereby enhanced the inhibition of iNOS signaling. Melatonin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 175-178 27865009-7 2017 Melatonin in combination with 5-FU markedly suppressed the phosphorylation of PI3K, AKT, IKKalpha, IkappaBalpha, and p65 proteins, promoted the translocation of NF-kappaB p50/p65 from the nuclei to cytoplasm, abrogated their binding to the iNOS promoter, and thereby enhanced the inhibition of iNOS signaling. Fluorouracil 30-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-120 27865009-7 2017 Melatonin in combination with 5-FU markedly suppressed the phosphorylation of PI3K, AKT, IKKalpha, IkappaBalpha, and p65 proteins, promoted the translocation of NF-kappaB p50/p65 from the nuclei to cytoplasm, abrogated their binding to the iNOS promoter, and thereby enhanced the inhibition of iNOS signaling. Fluorouracil 30-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 175-178 28065589-6 2017 Knockdown of PERK attenuated TG-induced CXCL10 and CCL2 mRNA expression, associated with significant decreases in phosphorylation of NF-kappaB RelA and STAT3. Thapsigargin 29-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 143-147 28344789-8 2017 Rosiglitazone significantly decreased p-NF-kB p65 phosphorylation and TGFbeta protein expression at 24 and 72 hours post-irradiation and significantly decreased gene expression of Collagen1, Mmp13, Tnfalpha and Bax at 24 hours and p53 at 72 hours post-irradiation. Rosiglitazone 0-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 46-49 28270294-13 2017 Western blot analysis showed a lower phosphorylation level of inhibitor of NF-kappaB in the Ang II group compared with the Sham group or Ang II+BTZ group,accompanied with an increased phosphorylation level of p65. Bortezomib 144-147 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 209-212 28187742-8 2017 Suppression of cPLA2alpha activity inhibited superoxide production by NOX2-NADPH oxidase and activation of NF-kappaB detected by the phosphorylation of p65 on serine 536 at 15 min by LPS and at 4 h by IFNgamma. Serine 159-165 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 152-155 28000518-5 2017 Artemisinin also inhibited TNF-alpha induced phosphorylation and degradation of IkappaBalpha, p65 nuclear translocation. artemisinin 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 94-97 27436852-8 2017 The RelA NF-kappaB subunit is activated by acetylation of lysine 310. Lysine 58-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 4-8 27988459-6 2017 While aurone 1 pre-treatment had no effect on the phosphorylation of ERK, JNK, or p38 MAPK, it strongly suppressed activation of IKK-beta, as indicated by attenuation of Ser176/180 phosphorylation, resulting in decreased phosphorylation of p65 (ser536) as well as phosphorylation (ser32) and degradation of IkappaBalpha. aurone 6-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 240-243 26385798-0 2017 Aldosterone-induced expression of ENaC-alpha is associated with activity of p65/p50 in renal epithelial cells. Aldosterone 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 76-79 26385798-4 2017 Aldosterone exposure led to up-regulation of ENaC-alpha and IKKbeta, and nuclear p65 and p50. Aldosterone 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 81-84 26385798-5 2017 Knockdown of IKKbeta or p65 exhibited >60 % reduction of aldosterone-induced ENaC-alpha mRNA levels. Aldosterone 60-71 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 24-27 27492973-0 2017 Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/beta-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Niclosamide 13-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 27492973-12 2017 CONCLUSIONS: Interaction of p65 with FOXM1/beta-catenin is critical in CML and its disruption by niclosamide eradicates LSCs. Niclosamide 97-108 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 28-31 27920257-3 2017 In turn, PKR stimulates nuclear accumulation of nuclear factor kappaB (NF-kappaB) p65 species phosphorylated at serine-536, which is paralleled by the induction of a subset of inflammatory NF-kappaB p65-responsive genes, including inducible nitric oxide synthase (iNOS), interleukin-6 (IL-6), and IL-1beta. Serine 112-118 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 28197211-13 2017 FFSO treatment reduced the number of cells showing NF-kappaB p65 and iNOS expression. ffso 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 61-64 28054586-10 2017 In conclusion, we found novel evidence suggesting that hepatic miR-291b-3p mediated glycogen synthesis and gluconeogenesis through targeting p65 to regulate PTEN expression. Glycogen 84-92 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 141-144 28867726-8 2017 The elevated concentrations of interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and IL-6, and the activation of nuclear factor-kappaB (NF-kappaB) p65 by ethanol stimulation was also reduced by acetate. Ethanol 162-169 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 155-158 28867726-8 2017 The elevated concentrations of interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and IL-6, and the activation of nuclear factor-kappaB (NF-kappaB) p65 by ethanol stimulation was also reduced by acetate. Acetates 202-209 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 155-158 28088324-8 2017 Meanwhile, the DSS exposure activated nuclear transcription factor kappa B p65 and inhibited nuclear factor E2-related factor 2 (Nrf2), while SCE markedly attenuated the DSS-promoted effect on the p65 nuclear accumulation and the DSS-inhibited effect on the Nrf2 nuclear accumulation. Dextran Sulfate 15-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 75-78 28088324-8 2017 Meanwhile, the DSS exposure activated nuclear transcription factor kappa B p65 and inhibited nuclear factor E2-related factor 2 (Nrf2), while SCE markedly attenuated the DSS-promoted effect on the p65 nuclear accumulation and the DSS-inhibited effect on the Nrf2 nuclear accumulation. Dextran Sulfate 15-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 197-200 28088324-8 2017 Meanwhile, the DSS exposure activated nuclear transcription factor kappa B p65 and inhibited nuclear factor E2-related factor 2 (Nrf2), while SCE markedly attenuated the DSS-promoted effect on the p65 nuclear accumulation and the DSS-inhibited effect on the Nrf2 nuclear accumulation. Dextran Sulfate 170-173 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 197-200 28088324-8 2017 Meanwhile, the DSS exposure activated nuclear transcription factor kappa B p65 and inhibited nuclear factor E2-related factor 2 (Nrf2), while SCE markedly attenuated the DSS-promoted effect on the p65 nuclear accumulation and the DSS-inhibited effect on the Nrf2 nuclear accumulation. Dextran Sulfate 170-173 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 197-200 28088324-9 2017 In conclusion, SCE conferred a protective role in the DSS-induced inflammation and the mechanism might be associated with the activated signals of the nuclear factor kappa B p65 and Nrf2. Dextran Sulfate 54-57 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 174-177 28465762-7 2017 Phosphorylation of Akt was increased and nuclear translocation of p65 NF-kappaB was decreased in paricalcitol-treated mice with IR injury, which was reversed by EP4 blockade. paricalcitol 97-109 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-79 28424738-5 2017 Mechanistically, treatment with LFXY significantly prevented LPS-induced TLR4 expression and NF-kappaB (p65) phosphorylation. lfxy 32-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 104-107 27696512-10 2017 Following DEN treatment, mice exhibited increased phosphorylation of PI3K, AKT, mTOR, STAT3, ERK, and p38, and a higher expression of NF-kappaB p50 and p65 subunits. Diethylnitrosamine 10-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 152-155 28676833-10 2017 The nuclear level of p65 protein was decreased in Andrographolide treatment group. andrographolide 50-65 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 21-24 27977755-6 2016 In these cells, decreased cytosol IkappaBalpha expression was elevated, and increased nuclear NF-kappaB p65 level and nuclear NF-kappaB p65 DNA binding activity were significantly reduced by taxifolin and cilostazol in a similar manner. taxifolin 191-200 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 104-107 29317794-7 2017 Gemigliptin also decreased the plasma levels of tumor necrosis factor-alpha and monocyte chemoattractant protein-1 and attenuated nuclear staining of nuclear factor kappa-B p65 in the kidneys. LC15-0444 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 173-176 27721021-6 2016 In mouse xenografts, intratumoral delivery of the phosphomimetic p65/S536D mutant increased the antitumor activity of RITA. RITA 118-122 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 65-68 27999284-4 2016 We demonstrated that aspirin inhibited hepcidin mRNA as well as NO production in cells treated with LPS, but not in cells without LPS, suppresses IL-6, JAK2, STAT3, and P65 (nuclear factor-kappaB) phosphorylation and has no effect on IRP1 in cells treated with or without LPS. Aspirin 21-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 169-172 27999284-5 2016 These findings provide evidence that aspirin down regulates hepcidin by inhibiting IL6/JAK2/STAT3 and P65 (nuclear factor-kappaB) pathways in the cells under inflammatory conditions, and imply that an aspirin-induced reduction in TfR1 and an increase in ferritin are not associated with IRP1 and NO. Aspirin 37-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-105 27977755-6 2016 In these cells, decreased cytosol IkappaBalpha expression was elevated, and increased nuclear NF-kappaB p65 level and nuclear NF-kappaB p65 DNA binding activity were significantly reduced by taxifolin and cilostazol in a similar manner. taxifolin 191-200 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-139 27977755-6 2016 In these cells, decreased cytosol IkappaBalpha expression was elevated, and increased nuclear NF-kappaB p65 level and nuclear NF-kappaB p65 DNA binding activity were significantly reduced by taxifolin and cilostazol in a similar manner. Cilostazol 205-215 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 104-107 27977755-6 2016 In these cells, decreased cytosol IkappaBalpha expression was elevated, and increased nuclear NF-kappaB p65 level and nuclear NF-kappaB p65 DNA binding activity were significantly reduced by taxifolin and cilostazol in a similar manner. Cilostazol 205-215 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-139 27825966-5 2016 We further found that hypericin ameliorates inflammatory response by suppressing MKL1, which is the essential cofactor of p65 during the transcription process. hypericin 22-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-125 27710897-8 2016 The results of Western blot and luciferase reporter assay indicated that BZ-26 not only inhibited NF-kappaB transcriptional activity, but also abolished LPS-induce nuclear translocation of P65. Quinuclidinyl Benzilate 73-75 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 189-192 27643555-8 2016 Moreover, resveratrol administration not only suppressed the NF-kappaB p65 nuclear translocation, NF-kappaB activity and ROS production in the LPS-treated mice, but also inhibited the LPS-induced thioredoxin-interacting protein (TXNIP) protein expression and interaction of TXNIP-NLRP3 in lung tissue. Resveratrol 10-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 71-74 27581278-4 2016 Furthermore, Western blot and immunofluorescence analysis indicated that neougonin A could inhibit the phosphorylation of IkBalpha and block the translocation of NF-kB/p65 into the nucleus even at 1.25 muM (P < 0.05), but have no effect on JNK, ERK1/2, and p38MAPK phosphorylation. neougonin A 73-84 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 168-171 27702567-9 2016 In addition, berberine reduced the elevated levels of serum TNF-alpha, IL-6 and MCP-1 and the expressions of TNF-alpha, IL-6 and MCP-1 and attenuated the phosphorylation of JNK and IKKbeta and the expression of NF-kappaB p65 in the obese adipose tissue, Raw264.7 macrophages and 3T3-L1 adipocytes, respectively. Berberine 13-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 221-224 27234497-12 2016 SaG2Fu and SaG4Fu also inhibited the activation and translocation of p65 NF-kappaB protein levels, resulting in reduction of NO, ROS, and PGE2 production. Reactive Oxygen Species 129-132 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-82 27234497-12 2016 SaG2Fu and SaG4Fu also inhibited the activation and translocation of p65 NF-kappaB protein levels, resulting in reduction of NO, ROS, and PGE2 production. Dinoprostone 138-142 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-82 30508357-7 2016 These results suggest that ETAS prevents pro-inflammatory responses by suppressing the p65 nuclear translocation in skin fibroblasts induced by H202. h202 144-148 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 87-90 27878238-8 2016 In addition, nobiletin suppressed LPS/GalN-induced phosphorylation and degradation of inhibitor of nuclear factor (NF)-kappaB (IkappaB)alpha, as well as NF-kappaB p65 translocation into the nucleus. nobiletin 13-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 163-166 27928219-8 2016 Western blot showed that SDS efficiently inhibited the phosphorylation of IkappaB-alpha, p65 NF-kappaB, and the expression of TLR4. rhodioloside 25-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 89-102 26961543-9 2016 The protective effect of CORM-2 could be simulated by BAY11-7082, a special inhibitor of NF-kappaB p65. 3-(4-methylphenylsulfonyl)-2-propenenitrile 54-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-102 27809877-10 2016 Synaptamide increased intracellular cAMP levels, phosphorylation of PKA, and phosphorylation of CREB but suppressed LPS-induced nuclear translocation of NF-kappaB p65. synaptamide 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 163-166 27601294-7 2016 Further investigation demonstrated that quercetin treatment significantly attenuated CCl4-induced nuclear translocation of the nuclear factor-kappaB (NF-kappaB) p65 and inhibited degradation of IkappaBalpha (an inhibitor of NF-kappaB) expression in the liver compared with vehicle-treated fibrotic mice. Quercetin 40-49 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 161-164 27562518-9 2016 Furthermore, ginkgolide and bilobalide also downregulated p-TAK1, p-IkBalpha, and p-IKKbeta and inhibited the OGD/R-induced transfer of NF-kappaB p65 from cytoplasm to nucleus in BV2 microglia cells. Ginkgolides 13-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 146-149 27562518-9 2016 Furthermore, ginkgolide and bilobalide also downregulated p-TAK1, p-IkBalpha, and p-IKKbeta and inhibited the OGD/R-induced transfer of NF-kappaB p65 from cytoplasm to nucleus in BV2 microglia cells. bilobalide 28-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 146-149 26961543-0 2016 Pretreatment of Mouse Neural Stem Cells with Carbon Monoxide-Releasing Molecule-2 Interferes with NF-kappaB p65 Signaling and Suppresses Iron Overload-Induced Apoptosis. Carbon Monoxide 45-60 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 108-111 27829992-6 2016 Treatment with DEX also attenuated IkappaB-alpha phosphorylation and further reduced NF-kappaB expression in the nucleus by decreasing acetylation of the p65 subunit. Dexamethasone 15-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 154-157 27487564-4 2016 Also, DMY markedly inhibited NO secretion, iNOS, and COX-2 protein expression, as well as p65 phosphorylation via suppression of IKKbeta activity and IKKalpha/beta phosphorylation in RAW264.7 cells. dihydromyricetin 6-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-93 27711079-3 2016 Ablation of Sirt1 shows remarkable protection against GalN/LPS-induced liver injury, which is a result of enhanced NF-kappaB response because knockdown of RelA/p65 negates the protective effect of Sirt1 knockout. Galactosamine 54-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 155-159 27711079-3 2016 Ablation of Sirt1 shows remarkable protection against GalN/LPS-induced liver injury, which is a result of enhanced NF-kappaB response because knockdown of RelA/p65 negates the protective effect of Sirt1 knockout. Galactosamine 54-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 160-163 27569861-5 2016 BHMB suppressed the phosphorylation and degradation of IkappaB-alpha and markedly inhibited the nuclear translocation of p65 and p50 in LPS-stimulated RAW 264.7 cells. 5-bromo-2-hydroxy-4-methyl-benzaldehyde 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-124 27531364-6 2016 Western blot and qPCR results showed that the expressions of P2X7 receptor protein and mRNA were positively dose-dependent with gp120 concentration; the results of immunocytochemistry and Western blot showed that the expressions of P2X7 receptor and P65 NF-kappaB in the gp120 group increased significantly compared to those of the control (Ctrl) group, but those in the gp120+BBG group decreased. coomassie Brilliant Blue 377-380 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 250-263 27535961-5 2016 When the recipient mice were treated with niclosamide for 3 weeks, niclosamide reduced the size of endometriotic implants with inhibition of cell proliferation, and inflammatory signaling including RELA (NFKB) and STAT3 activation, but did not alter expression of steroid hormone receptors. Niclosamide 42-53 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 198-202 27535961-5 2016 When the recipient mice were treated with niclosamide for 3 weeks, niclosamide reduced the size of endometriotic implants with inhibition of cell proliferation, and inflammatory signaling including RELA (NFKB) and STAT3 activation, but did not alter expression of steroid hormone receptors. Niclosamide 67-78 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 198-202 27226975-0 2016 Single-particle tracking uncovers dynamics of glutamate-induced retrograde transport of NF-kappaB p65 in living neurons. Glutamic Acid 46-55 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 98-101 26931732-5 2016 Furthermore, molecular mechanism studies indicated that alpha-solanine inhibited LPS-induced activation of nuclear factor-kappaB (NF-kappaB) by reducing nuclear translocation of p65, degradation of inhibitory kappaBalpha (IkappaBalpha), and phosphorylation of IkappaB kinasealpha/beta (IKKalpha/beta). alpha-solanine 56-70 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 178-181 27226975-6 2016 Glutamate treatment resulted in an increase of the mean retrograde velocity from [Formula: see text] to [Formula: see text], whereas a velocity increase from [Formula: see text] to [Formula: see text] was observed for anterogradely transported p65. Glutamic Acid 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 244-247 27226975-7 2016 This study demonstrates for the first time that glutamate stimulation leads to an increased mobility of single NF-kappaB p65 molecules in neurites of living hippocampal neurons. Glutamic Acid 48-57 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-124 27185116-5 2016 Additionally, activation of the nuclear factor kappaB p65 (NF-kappaB p65), c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) induced by BBG, were also observed, further confirming the stimulation of RAW264.7 cells by BBG. bbg 164-167 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 54-57 27707649-6 2016 The results showed that RA could effectively suppress tumor growth with fewer toxic effects by regulating the secretion of cytokines associated with inflammation and angiogenesis, and suppressing the expression of NF-kappaB p65 in the xenograft microenvironment. rosmarinic acid 24-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 224-227 27685808-6 2016 Our in silico analysis revealed the binding of oxazines to the hydrophobic cavity that present between the interface of p65 and IkappaBalpha. Oxazines 47-55 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 120-123 27662828-7 2016 In contrast, mating of RelACKO/CKO mice with Col1alpha2-CreER mice allowed for the generation of double transgenics which could be stimulated with tamoxifen to induce fibroblast-specific RelA deletion in adulthood. Tamoxifen 147-156 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 23-27 27608299-9 2016 Western blot analysis confirmed the decreased expression of IL-17, GITR, NF-kappaB p65 proteins and increased Foxp3 and IL-4 proteins following AG126 treatment of knee tissue. AG 127 144-149 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 83-86 27381458-7 2016 Ifrd1 deficiency increased the acetylation of p65 at residues K122 and K123 via the inhibition of histone deacetylase-dependent deacetylation in BMMs. All trans-Teprenone 71-75 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 46-49 27533461-12 2016 The results revealed that suppressing miR-744-3p was effective to inhibit LSCC metastasis by inactivating AKT/mTOR and NF-kappaB (p65) signaling cascade. mir-744 38-45 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 130-133 26748661-7 2016 Tetrandrine could inhibit IL-6, IL-1beta, and TNF-alpha expression via blocking the nuclear translocation of nuclear factor (NF)-kappaB p65 in LPS-induced RAW 264.7 cells. tetrandrine 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-139 26748661-9 2016 In conclusion, the results showed that one of the anti-inflammatory mechanisms of tetrandrine was inhibiting IkappaBalpha and NF-kappaB p65 phosphorylation in LPS-induced macrophage RAW 264.7 cells and chondrogenic ATDC5 cells. tetrandrine 82-93 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-139 27185116-5 2016 Additionally, activation of the nuclear factor kappaB p65 (NF-kappaB p65), c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) induced by BBG, were also observed, further confirming the stimulation of RAW264.7 cells by BBG. bbg 164-167 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-72 27185116-5 2016 Additionally, activation of the nuclear factor kappaB p65 (NF-kappaB p65), c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) induced by BBG, were also observed, further confirming the stimulation of RAW264.7 cells by BBG. bbg 245-248 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 54-57 27500900-5 2016 Using co-immunoprecipitation assays, we observed the constitutive activation of nuclear factor kappa-b (NF-kappaB) p65 and its interaction with the progesterone receptor (PGR); moreover, transcriptional activity of the PGR was also repressed by NF-kappaB activity in primary mouse and human decidual stromal cells that mimic progesterone maintenance. Progesterone 148-160 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 115-118 27430169-6 2016 The immunofluorescence assay indicated that aspirin markedly inhibited NF-kappaB p65 translocation to the nucleus in RANKL-induced RAW264.7 cells. Aspirin 44-51 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 81-84 26853469-5 2016 Unlike RelA knockout mice, the RelA T505A mice develop normally but exhibit aberrant hepatocyte proliferation following liver partial hepatectomy or damage resulting from carbon tetrachloride (CCl4) treatment. Carbon Tetrachloride 171-191 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-35 26853469-6 2016 Consistent with these effects, RelA T505A mice exhibit earlier onset of cancer in the N-nitrosodiethylamine model of hepatocellular carcinoma. Diethylnitrosamine 86-107 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-35 27518439-13 2016 CONCLUSIONS: Mice with CSE (an H2S synthesising enzyme) gene deletion are less susceptible to CLP-induced sepsis and associated inflammatory response through ERK1/2-NF-kappaB p65 pathway as evidenced by reduced inflammation, tissue damage, and LSECs defenestration and gaps formation. Hydrogen Sulfide 31-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 175-178 27558652-8 2016 Further, wedelolactone blocked NF-kB/p65 phosphorylation and abrogated the NFATc1 nuclear translocation. wedelolactone 9-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 37-40 27555662-7 2016 Together, our results suggest that Ser(534) phosphorylation of p65 in mice (and, by extension, Ser(536) phosphorylation of human p65) is not required for its nuclear translocation, but instead inhibits NF-kappaB signaling to prevent deleterious inflammation. Serine 35-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 63-66 27351430-5 2016 The results also showed that 1,8-cineol reduced the expression of NF-kB p65, intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1 in lung tissues. Eucalyptol 29-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 27206337-8 2016 Moreover, overexpression of NF-kappaB p65 reversed the inhibitory effect of LFG-500 on LPS-induced NF-kappaB activation and inflammatory cytokine secretion. LFG-500 76-83 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 38-41 27156691-9 2016 Moreover, blockade of PI3K/Akt activation by LY294002 significantly reduced inflammation response and NF-kappaB p65 nuclear translocation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 45-53 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 112-115 27414646-4 2016 Eupafolin inhibited the LPS-induced phosphorylation of p38 MAPK, ERK1/2, JNK, AKT and p65 and the nuclear translocation of p65 and c-fos. eupafolin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 86-89 27216047-12 2016 In addition, calcitriol blocked LPS-induced nuclear translocation of nuclear factor kappa B (NF-kappaB) p65 and p50 subunit in the lungs. Calcitriol 13-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 104-107 27349640-6 2016 RE administration prevented the DSS-induced activation of p38, ERK and JNK MAPKs, attenuated IkappaBalpha phosphorylation and subsequent nuclear translocation and DNA binding of NF-kappaB (p65). Dextran Sulfate 32-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 189-192 27155455-6 2016 Biochemically, the high concentration of ST2825 significantly reduced the levels of MyD88, further decreased TAK1, p-TAK1, nuclear p65 and increased IkappaB-alpha. ST2825 41-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 131-134 27414646-4 2016 Eupafolin inhibited the LPS-induced phosphorylation of p38 MAPK, ERK1/2, JNK, AKT and p65 and the nuclear translocation of p65 and c-fos. eupafolin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 123-126 27261579-5 2016 Likewise, GB and GM possess almost the same potency in attenuating LPS-induced expression and activation of nuclear factor kappa B (p65) and subsequent increases in tumor necrosis factor-alpha mRNA levels. ginkgolide B 10-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 132-135 27129186-3 2016 Mechanistically, TCF-4 functioned as a co-activator of p65 to amplify the saturated free fatty acid (FFA)-stimulated promoter activity, mRNA transcription and secretion of proinflammatory cytokines in primary macrophages. saturated free fatty acid 74-99 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 27129186-4 2016 Blockage of p65 with a specific interfering RNA or inhibitor could prevent TCF-4-enhanced expression of proinflammatory cytokines in FFA/lipopolysaccharide-treated primary macrophages. Fatty Acids, Nonesterified 133-136 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 12-15 27129186-5 2016 The p65 inhibitor could abolish macrophage TCF-4 transgene-aggravated systemic inflammation, glucose intolerance and insulin resistance in HFD-treated mice. Glucose 93-100 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 4-7 30090448-7 2016 Consistent with these results, H-PM induced the phosphorylation of nuclear factor kappaB (NF-kappaB) p65 and I kappa B kinase (IKK), which was inhibited by co-administration of LPS. h-pm 31-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 27261579-5 2016 Likewise, GB and GM possess almost the same potency in attenuating LPS-induced expression and activation of nuclear factor kappa B (p65) and subsequent increases in tumor necrosis factor-alpha mRNA levels. gm 17-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 132-135 27027358-7 2016 Paeonol also inhibits the expression of phosphorylated NF-kappaB p65, IkappaBalpha and IKKbeta, and restrains NF-kappaB p65 DNA-binding activity. paeonol 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 65-68 27176922-5 2016 Molecular-level studies indicated that the DHA + QE combination can significantly inhibit the mRNA expression of NF-kappaB subunits p50 and p65, extracellular signal-regulated kinase (ERK) 1/2 and c-JUN N-terminal kinase (JNK) 1/2, which suggests that the NF-kappaB signalling pathway is involved in the synergistic effects observed. Docosahexaenoic Acids 43-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 140-143 27176922-5 2016 Molecular-level studies indicated that the DHA + QE combination can significantly inhibit the mRNA expression of NF-kappaB subunits p50 and p65, extracellular signal-regulated kinase (ERK) 1/2 and c-JUN N-terminal kinase (JNK) 1/2, which suggests that the NF-kappaB signalling pathway is involved in the synergistic effects observed. Quercetin 49-51 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 140-143 27176922-6 2016 Furthermore, western blot analysis demonstrated that DHA + QE synergistically inhibit the phosphorylation of p50, p65, ERK1/2 and JNK1/2. Docosahexaenoic Acids 53-56 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-117 27176922-6 2016 Furthermore, western blot analysis demonstrated that DHA + QE synergistically inhibit the phosphorylation of p50, p65, ERK1/2 and JNK1/2. Quercetin 59-61 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-117 26961887-5 2016 Moreover, DDA significantly suppress LPS-mediated nuclear factor-kappaB (NF-kappaB) activation by inhibiting phosphorylation and nuclear translocation of NF-kappaB p65. dda 23-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 177-180 27050799-7 2016 Furthermore, OMT administration inhibited the release of inflammatory factors including tumor necrosis factor-alpha, (TNF-alpha) interleukin-1beta (IL-1beta), and interleukin-6 (IL-6), as well as phosphorylated NF-kappaB p65. oxymatrine 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 221-224 26933138-12 2016 Moreover, IL-17 activated the phosphorylation of IkappaBalpha and p65 in SMG cells, whereas pretreatment with NF-kappaB inhibitor pyrrolidine dithiocarbamate suppressed the IL-17-induced downregulation of claudin-4 and ZO-1 in SMG tissues. pyrrolidine dithiocarbamic acid 130-157 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 27107388-8 2016 The obtained results showed that liquiritigenin effectively reduced the levels of pro-inflammatory cytokines and the expressions of p-p65NF-kappaB and p-IkappaBalpha. liquiritigenin 33-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 134-146 27027358-7 2016 Paeonol also inhibits the expression of phosphorylated NF-kappaB p65, IkappaBalpha and IKKbeta, and restrains NF-kappaB p65 DNA-binding activity. paeonol 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 120-123 27039209-9 2016 Further study showed that sophocarpine could suppress the phosphorylation of IkappaBalpha, p65 and p38. sophocarpine 26-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-94 27284967-5 2016 Using immunoprecipitation assay in a Treg-like cell line Karpas-299, we found that epirubicin inhibited the interaction between Foxp3 and p65. Epirubicin 83-93 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 138-141 27018751-13 2016 alpha-LA inhibited the phosphorylation of NF-kappaB p65, IkappaBalpha and JNK. Thioctic Acid 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 52-55 27068879-5 2016 These findings showing that RelA controls Treg stability and promotes the competitive fitness of effector Tregs highlight the importance of RelA activity in peripheral Treg induced tolerance. treg 42-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 28-32 27089391-10 2016 The results showed that plantamajoside inhibited the phosphorylation of IkappaBalpha, p65, p38, JNK and ERK. plantamajoside 24-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 86-89 27074053-6 2016 The preemptive administration of Dex substantially abated sepsis-induced pulmonary edema, pulmonary histopathological changes, and NF-kappaB p65 activity. Dexmedetomidine 33-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 141-144 26891685-9 2016 The data demonstrated that boldine may be beneficial in colitis through selective immunomodulatory effects, which may be mediated, at least in part, by inhibition of p65-NF-kappaB and STAT3 signaling pathways. boldine 27-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 166-179 27082984-8 2016 UA also reduced the DSS-stimulated high nuclear level of NF-kappaB p65 in the colon tissues. ursolic acid 0-2 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 67-70 27082984-8 2016 UA also reduced the DSS-stimulated high nuclear level of NF-kappaB p65 in the colon tissues. Dextran Sulfate 20-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 67-70 27347321-5 2016 The results demonstrated that the ethanol extract from POL could exhibit the effective protection for the DSS induced UC by increasing the colon length, decreasing body weight loss and the disease activity index score, inhibiting oxidative stress response through the MDA, NO, SOD activities, reducing the mRNA expressions of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) and the protein expressions of TNF-alpha and NF-kB p65. Ethanol 34-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 435-438 26927696-8 2016 Ischemia-induced GSH adducts on specific cysteine residues of several proteins, including p65 NF-kB and the sarcoplasmic reticulum calcium ATPase 2, evidently promote ischemic angiogenesis. Glutathione 17-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-93 26927696-8 2016 Ischemia-induced GSH adducts on specific cysteine residues of several proteins, including p65 NF-kB and the sarcoplasmic reticulum calcium ATPase 2, evidently promote ischemic angiogenesis. Cysteine 41-49 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-93 27212040-7 2016 Honokiol significantly blocked TNF-alpha-induced NF-kappaB p65 nuclear translocation and degradation of the proteasome-dependent inhibitor of NF-kappaB alpha (IkappaBalpha). honokiol 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-62 27144271-10 2016 Pre-treatment with paeonol significantly inhibited IKKalpha/beta, IkappaBalpha and p65 phosphorylation which contributed to ameliorating APAP-induced hepatic inflammation. paeonol 19-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 83-86 27050422-9 2016 Moreover, pre-treatment with quercetin not only inhibited OA-induced apoptosis via the reduction of Bax, and up-regulation of cleaved caspase 3, but also via the inhibition of PI3K/Akt/GSK3beta, MAPKs and activation of NF-kappaB p65. Quercetin 29-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 229-232 27041460-12 2016 Moreover, hyperoside inhibited LPS-induced phosphorylation of p65 and IkappaBalpha, and suppressed LPS-induced nuclear translocation of p65 and DNA biding of NF-kappaB in the cells. hyperoside 10-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 62-65 27041460-12 2016 Moreover, hyperoside inhibited LPS-induced phosphorylation of p65 and IkappaBalpha, and suppressed LPS-induced nuclear translocation of p65 and DNA biding of NF-kappaB in the cells. hyperoside 10-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-139 27104958-7 2016 RT-PCR analysis revealed an increased mRNA expression of IL-6, TNF-alpha, COX-2, iNOS, and NF-kappaB p65 and decreased IL-10 in the LPS group, which were reversed by treatment with DEX in lung tissues. Dexamethasone 181-184 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 27104958-8 2016 Western blot analysis revealed an increased expression of COX-2, iNOS and NF-kappaB p65 in the LPS-group, which was reduced by treatment with DEX. Dexamethasone 142-145 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 26686910-6 2016 Western blot analysis showed that CX significantly suppressed NF-kappaB (p65) activation as well as MAPK phosphorylation. Beta-Cryptoxanthin 34-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-76 26657007-11 2016 Cardiac myeloperoxidase activity, the intensity of dihydroethidium staining and the phosphorylation of nuclear factor-kappaB p65 were also lower in the CPE group compared with the vehicle group. cpe 152-155 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 125-128 26954764-9 2016 In a mouse model of LPS-induced myocardial inflammation, pre-treatment with paricalcitol prevented the LPS-induced increase in the expression of myocardial ICAM-1, phosphorylated p65 and myocardial TNF-alpha. paricalcitol 76-88 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 179-182 26500095-11 2016 TQ has also been shown to induce protein levels of cleaved Caspase-3, Caspase-7, and Caspase-12 and PARP and to reduce phosphorylated p65 and Akt1. thymoquinone 0-2 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 134-137 26798022-12 2016 Finally, transcription factors, including STAT1, STAT3, and p65, were greatly suppressed by vorinostat treatment. Vorinostat 92-102 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 60-63 27011173-5 2016 Furthermore, koumine decreased the phosphorylation of p65 and inhibited nuclear factor kappa Balpha (IkappaBalpha) proteins, resulting in lower production of nuclear factor (NF)-kappaB transactivation. koumine 13-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 54-57 27236893-13 2016 NF-kappaB/p65 was translocated from cytoplasm to nucleus after stimulated by 45 min TNF-alpha in the TNF-alpha group, while it could be significantly inhibited in the high dose PAE group. peoniflorin 177-180 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 10-13 26915320-8 2016 The results showed that LPS/D-gal induced the enhanced expression of TF, elevation of NF-kappaB p65 nuclear translocation, up-regulation of HIF-1alpha and EPO expressions, and increased LA level. Galactosamine 28-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-99 26745676-5 2016 The in vivo effect of NF-kappaB activation is positively correlated with p-STAT3, Ki67, CK14 or beta-catenin expression, while GDFs induce significant transcriptional activation of RELA(p65), bcl-2, TNF-alpha, STAT3, EGFR and wnt5A, in vivo. gdfs 127-131 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 181-185 26907256-4 2016 Cudraflavanone D (1) also decreased IL-6, TNF-alpha, IL-12, and IL-1beta production, blocked nuclear translocation of NF-kappaB heterodimers (p50 and p65) by interrupting the degradation and phosphorylation of inhibitor of IkappaB-alpha, and inhibited NF-kappaB binding. cudraflavanone 0-14 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 150-153 29931859-1 2016 OBJECTIVE: To study the changes of colonic permeability and its correlation with TNF-alpha, NF-kappaB p65 in indextran sulphate sodium (DSS) -induced ulcerative colitis(UC) of mice. indextran sulphate sodium 109-134 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-105 26937141-10 2016 Moreover, PA increased but DHA decreased phosphorylated NF-kappaB p65 protein expression in hepatocytes. Docosahexaenoic Acids 27-30 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 26745676-5 2016 The in vivo effect of NF-kappaB activation is positively correlated with p-STAT3, Ki67, CK14 or beta-catenin expression, while GDFs induce significant transcriptional activation of RELA(p65), bcl-2, TNF-alpha, STAT3, EGFR and wnt5A, in vivo. gdfs 127-131 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 186-189 26761723-6 2016 Investigation of the effect on nuclear factor kappaB (NF-kappaB) signaling pathway showed that corymbocoumarin inhibited the phosphorylation of Akt and inhibitory kappaB (IkappaB)-alpha and decreased the subsequent translocation of the p65 and p50 NF-kappaB subunits to the nucleus. Corymbocoumarin 95-110 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 236-239 26718746-9 2016 CONCLUSION: HAO472 has positive effects on TNBS-induced colitis by modulating the subsets and functions of lymphocytes, suppressing inflammation and inhibiting the nuclear translocation of NF-kappaB p65 subunits. HAO472 12-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 199-202 26647854-9 2016 The inhibitory effect of L-carnitine on the increased expression level of nuclear factor (NF)-kappaB p65 in the peripheral blood mononuclear cells was markedly weakened by GW9662, a selective inhibitor of PPAR-gamma. Carnitine 25-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 26267064-7 2016 Quercetin pretreatment significantly inhibited degradation of inhibitory kappa B alpha and modulated ConA-induced nuclear translocation in the liver of nuclear factor kappa B (NF-kappaB) p65. Quercetin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 187-190 26878795-6 2016 Further studies revealed that fisetin suppressed the activation of NF-kappaB (p65) by inhibiting IkappaBalpha phosphorylation and NF-kappaB (p65)-DNA binding activity and attenuated the phosphorylation of Akt and the p38, but not ERK and JNK MAPKs in the colon tissues of DSS-exposed mice. fisetin 30-37 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 78-81 26878795-6 2016 Further studies revealed that fisetin suppressed the activation of NF-kappaB (p65) by inhibiting IkappaBalpha phosphorylation and NF-kappaB (p65)-DNA binding activity and attenuated the phosphorylation of Akt and the p38, but not ERK and JNK MAPKs in the colon tissues of DSS-exposed mice. fisetin 30-37 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 141-144 26878795-6 2016 Further studies revealed that fisetin suppressed the activation of NF-kappaB (p65) by inhibiting IkappaBalpha phosphorylation and NF-kappaB (p65)-DNA binding activity and attenuated the phosphorylation of Akt and the p38, but not ERK and JNK MAPKs in the colon tissues of DSS-exposed mice. dss 272-275 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 78-81 26647854-9 2016 The inhibitory effect of L-carnitine on the increased expression level of nuclear factor (NF)-kappaB p65 in the peripheral blood mononuclear cells was markedly weakened by GW9662, a selective inhibitor of PPAR-gamma. 2-chloro-5-nitrobenzanilide 172-178 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 26647854-12 2016 Taken together, these results demonstrated that L-carnitine ameliorated liver inflammation and serum pro-inflammatory markers in cancer cachexia through regulating CPT I-dependent PPARgamma signaling, including the downstream molecules of NF-kappaB p65 and Cox-2. Carnitine 48-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 249-252 26597885-7 2016 Furthermore, IL-10 significantly inhibited the ultra-high-molecular-weight polyethylene particle-elevated phospho-STAT1 and phospho-NF-kappaB p65 productions, and promoted phospho-STAT3 expression. Polyethylene 75-87 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 142-145 26597859-8 2016 In addition, lobastin suppressed TNF-alpha-induced IkappaB kinase activation, subsequent degradation of IkappaBalpha and nuclear translocation of p65 NF-kappaB. CHEMBL4163641 13-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 146-159 26520185-10 2016 Moreover, BLM-induced nuclear translocation of nuclear factor kappa B (NF-kappaB) p65 was blocked by calcitriol. Bleomycin 10-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 26520185-10 2016 Moreover, BLM-induced nuclear translocation of nuclear factor kappa B (NF-kappaB) p65 was blocked by calcitriol. Calcitriol 101-111 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 26725521-9 2016 Therefore, our study unveils the role of TERT in macrophage polarization and the cross-talk between TERT and p65, which may provide a possible explanation for the ethanol-mediated hepatic proinflammatory response and M1 macrophage polarization. Ethanol 163-170 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-112 26499331-7 2016 Furthermore, crebanine inhibited LPS-induced nuclear factor kappa B (NF-kappaB) activation by reducing the phosphorylation of p65 at Ser536 but not the p65 translocation to the nucleus and inhibitory factor kappa B alpha degradation. crebanine 13-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 126-129 27413418-7 2016 Furthermore, H2S treatment decreased the protein expression of p50, p65, and p-p65 in the kidney of HFD-induced obese mice. Hydrogen Sulfide 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 28119929-6 2016 Proinflammatory cytokines were decreased and the expression of NF-kappaB p65 in acinar cell nuclei was suppressed after aspirin treatment. Aspirin 120-127 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-76 27034698-8 2016 Furthermore, LCF granule decreased p65 NF-kappaB levels and increased Sirt1 and Nrf2 levels in the kidney tissues of MRL/lpr mice, which might elucidate the beneficial effects of LCF on lupus nephritis. licofelone 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 35-38 26807019-8 2016 Further results showed that CA treatment markedly inhibited APAP-induced pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6 and MCP-1 mRNA expression and the levels of phosphorylated IkappaBalpha and p65 protein in the liver. Acetaminophen 60-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 202-205 26453063-9 2016 Skeletal muscle tissue from streptozotocin-treated diabetic mice also showed Prep1 overexpression accompanied by similarly increased recruitment of NF-kappaB p65 and histone modifications at the 5" region of Prep1. Streptozocin 28-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 158-161 26604089-8 2016 The Western blot results consistently demonstrated that butyrate pretreatment attenuated the phosphorylation of NF-kappaB p65, p38 MAPK and ERKs in the gastric tissues. Butyrates 56-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-125 26606860-9 2016 Baicalein treatment also interferes with doxorubicin-induced myocardial NF-kappaB signaling through inhibition of IkappaBalpha phosphorylation and nuclear translocation of p65 subunit. baicalein 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 172-175 26606860-9 2016 Baicalein treatment also interferes with doxorubicin-induced myocardial NF-kappaB signaling through inhibition of IkappaBalpha phosphorylation and nuclear translocation of p65 subunit. Doxorubicin 41-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 172-175 27504150-6 2016 Furthermore, quercetin resulted in phosphoinositide 3-kinase (PI3K) induction, Ca(2+) restoration, and blockade of the activities of Jun N-terminal kinase (JNK), activating transcription factor 6 (ATF6) and especially NF-kappaB (p65 and p50 nuclear translocation). Quercetin 13-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 229-232 26806739-4 2016 RESULTS: Compared with PBS-treated mice, the mice treated with cabozantinib showed a significantly higher survival rate, lower bacterial counts in the blood and brain (P<0.05 or 0.001), lower IL-10 (P<0.05) and NF-kappaB p65 levels (P<0.01), lower brain EB content (P<0.001), and milder pathological changes in the brain. cabozantinib 63-75 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 227-230 26702389-5 2015 To investigate the role of spleen in the treatment of Dex against sepsis, we studied the effects of preemptive administration of Dex to septic mice on the NF-kappaB p65 activation and downstream pro-inflammatory cytokine expression in the spleen. Dexmedetomidine 129-132 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 165-168 26702389-6 2015 Our results provided evidence that Dex treatment attenuated LPS-activated NF-kappaB p65 activation, as well as the production of tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta at the level of both mRNA and protein in spleen. Dexmedetomidine 35-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 26601804-6 2015 In L4-6 spinal cord, troxerutin reduced the expression of INF-gamma, IL-1beta, TNF-alpha, and activation of NF-kappaB(p65). troxerutin 21-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-121 26515065-3 2015 Following food deprivation, the expression and acetylation of the p65 of NF-kappaB on lysine 310 increase markedly in muscles. Lysine 86-92 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 26515065-4 2015 NF-kappaB inhibition in mouse muscles by overexpression of the IkappaBalpha superrepressor (IkappaBalpha-SR) or of p65 mutated at Lys-310 prevented atrophy. Lysine 130-133 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 115-118 26191652-7 2015 Also, Cilo administration markedly reduced Dox-induced levels of serum B-type natriuretic peptide, dysferlin, high-mobility group protein B1, Toll-like receptor 4, nuclear factor-kappaB p65, and cyclooxygenase-2. Cilostazol 6-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 186-189 26519533-8 2015 Similarly, IgM/LPS-pretreated BMDC are rendered nonprotective by increasing CD40 expression and phosphorylation of p65 NF-kappaB. bmdc 30-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 115-118 26490221-12 2015 GTS-21 also suppressed LPS-induced phosphorylation of NF-kappaBp65, IKKalpha/beta, IkappaBalpha, and Akt, as well as NF-kappaB p65 nuclear translocation. 3-(2,4-dimethoxybenzylidene)anabaseine 0-6 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 63-66 25835814-10 2015 SAE inhibited the phosphorylation of p65, an observation that occurred independently of IKKalphabeta-mediated IkappaBalpha phosphorylation. SELENAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 37-40 26498481-10 2015 Furthermore, the present study observed that NF-kappaB/p65 immunoreactivity was obviously increased in the SP and GCL at 6, 12 and 24 h after TeT treatment. sp 107-109 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 26625143-10 2015 We demonstrated that treating HASMC with TNF-alpha induced cell Ca deposit and result in an increase in ALP, NADPH oxidase activity, NF-kB subunit p65, BMP2, MSX2, and RUNX2 expression. hasmc 30-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 147-150 26377645-7 2015 Additionally, in mouse splenocytes or CH12.LX cells, binding within the hs1.2 and hs4 enhancer of the AhR and the NF-kappaB/Rel proteins RelA and RelB was differentially altered by the cotreatment of LPS and TCDD. Polychlorinated Dibenzodioxins 208-212 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 137-141 26361726-11 2015 Western blot analysis confirmed the increased protein expression of IL-1beta, TNF-alpha and NF-kappaB p65 in the LPS group and treatment of animals with diosmin reversed these effects. Diosmin 153-160 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-105 25835814-11 2015 Collectively, our results demonstrate that SAE suppressed NO( )-mediated inflammation by inhibiting p65 transcriptional activation without affecting IKKalphabeta-mediated IkappaBalpha phosphorylation. SELENAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE 43-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 100-103 26549505-6 2015 Mechanistically, Rocaglamide-A inhibited the phosphorylation of NF-kappaB component p65 protein and the accumulation of p65 in nucleus, which resulted in the diminished NF-kappaB responsible transcriptional activity. rocaglamide 17-30 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 26549505-6 2015 Mechanistically, Rocaglamide-A inhibited the phosphorylation of NF-kappaB component p65 protein and the accumulation of p65 in nucleus, which resulted in the diminished NF-kappaB responsible transcriptional activity. rocaglamide 17-30 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 120-123 26549505-7 2015 Oppositely, overexpression of p65 reversed rocaglamide-A"s protective effects on osteoblast differentiation. rocaglamide 43-54 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 30-33 26378023-7 2015 Administration of the p65 inhibitor parthenolide significantly improved hematology and myelogram indices while prolonging the life span of erythroleukemia mice. parthenolide 36-48 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 22-25 26038580-0 2015 Inactivation of NF-kappaB p65 (RelA) in Liver Improves Insulin Sensitivity and Inhibits cAMP/PKA Pathway. Cyclic AMP 88-92 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 26-29 26271896-7 2015 delta-Amyrone treatment significantly decreased mortality rate, tissues myeloperoxodase (MPO) activity, p65 NF-kappaB protein expression when compared with the LPS groups. amyrone 0-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 104-117 26492242-10 2015 Pretreatment with PI3K/AKT inhibitor LY294002 strikingly ameliorated the inhibitory effects of miR-223 on the activation of TLR4 and p65, concomitant with the increase in lipid deposition and inflammatory cytokine production. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 37-45 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 133-136 26148936-6 2015 Silencing TRAF3IP2 blunted Aldo-induced IKKbeta, p65, JNK, and c-Jun activation, IL-18, IL-6 and CT-1 upregulation, and cardiomyocyte hypertrophy. Aldosterone 27-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 49-52 26038580-0 2015 Inactivation of NF-kappaB p65 (RelA) in Liver Improves Insulin Sensitivity and Inhibits cAMP/PKA Pathway. Cyclic AMP 88-92 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-35 26370415-9 2015 Under 3 h" hypoxic stimulation, the nuclear contents of p65 and hypoxia inducible factor-1alpha (HIF-1alpha) significantly increase, while the cytosol IkappaB-alpha content decreases; these effects can be reversed by 1 h"s pre-incubation of 10(-8) M harpagoside. harpagoside 250-261 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 56-59 24838344-11 2015 In vivo, berberine also activated AMPK, inhibited mTOR and p65 phosphorylation and activated caspase-3 cleavage. Berberine 9-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-62 26370415-10 2015 Harpagoside could decrease IkappaB-alpha protein phosphorylation and inhibit p65 protein translocation from the cytosol to the nucleus, thus suppress NF-kappaB activation and reduce the HIF-1alpha generation. harpagoside 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-80 26319951-7 2015 In addition, GA reduced the activation and nuclear accumulation of p-STAT3(Y705), preventing the degradation of the inhibitory protein IkappaB and inhibiting of the nuclear translocation of p65-NF-kappaB in colonic mucosa. Gallic Acid 13-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 190-203 26319951-8 2015 These findings suggest that GA exerts potentially clinically useful anti-inflammatory effects mediated through the suppression of p65-NF-kappaB and IL-6/p-STAT3(Y705) activation. Gallic Acid 28-30 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 130-143 26102009-8 2015 Furthermore cavidine inhibited the level of TNF-alpha and IL-6 in the serum and colon tissue in response to the regulation of p65 NF-kappaB protein expression. cavidine 12-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 126-139 26190278-9 2015 Western blot analyses revealed that geraniol interfered with NF-kappaB signaling by inhibiting NF-kappaB (p65)-DNA binding, and IkappaBalpha phosphorylation, degradation and subsequent increase in nuclear translocation. geraniol 36-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 106-109 26370562-0 2015 O-linked N-acetylglucosamine glycosylation of p65 aggravated the inflammation in both fibroblast-like synoviocytes stimulated by tumor necrosis factor-alpha and mice with collagen induced arthritis. o-linked n-acetylglucosamine 0-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 46-49 26370562-1 2015 INTRODUCTION: We investigated the inflammatory potential of O-linked N-acetylglucosamine glycosylation (O-GlcNAcylation) of p65 in rheumatoid arthritis (RA). o-linked n-acetylglucosamine 60-88 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 124-127 26285901-4 2015 Mechanistic studies show that MLB counteracts Abeta (1-42)-induced activation of the nuclear factor kappa B (NF-kappaB) pathway, evidenced by the suppression of NF-kappaB luciferase reporters, decreased expression of phosphorylated Inhibitor kappaB alpha and IkappaB kinase alpha, and reduced nuclear translocation of p65 in response to pre-treatment with 50 mug/ml MLB prior to Abeta (1-42) exposure. UNII-042A8N37WH 46-51 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 318-321 26225925-5 2015 In addition, resveratrol inhibited the hypoxia-induced degradation of IkappaB-alpha and phosphorylation of p65 NF-kappaB protein. Resveratrol 13-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-120 25978030-4 2015 We found that MC-38 mouse colon cancer cells contain functional hypoxic (HIF-1alpha) and inflammatory (p65/RelA) signaling pathways. mc-38 14-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 103-106 26005209-10 2015 IGS also reduced the activation of the transcription factor nuclear factor-kappaB p65 in the colon tissue of DSS-treated mice. Dextran Sulfate 109-112 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 25978030-4 2015 We found that MC-38 mouse colon cancer cells contain functional hypoxic (HIF-1alpha) and inflammatory (p65/RelA) signaling pathways. mc-38 14-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-111 26346978-12 2015 Consistently, TMZ combined with FLT markedly attenuated NF-kappaB/p65 activity, reduced MGMT expression, and suppressed in vivo tumor growth in the murine subcutaneous xenograft model. Temozolomide 14-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 26161720-3 2015 One of the 1,2-dihydroisoquinoline derivatives was found to be a potent inhibitor for transcription factor NF-kappaB by blocking IkappaBalpha degradation, p65 nuclear translocation, and NF-kappaB DNA binding in TNF-alpha-induced NIH 3T3 cells. G 1617 11-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 155-158 26150530-6 2015 Furthermore, we establish that nuclear levels of NF-kappaB/p65 are increased in TLR/adenosine-stimulated NR4A2-depleted cells. Adenosine 84-93 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-62 26015438-3 2015 Regarding the molecular mechanism, LPS-induced degradation of IkappaBalpha and phosphorylations of p65, JNK, and p38, as well as NF-kappaB and AP-1 promoter activities, were revealed to be suppressed by incubation with anagliptin, indicating suppressive effects of anagliptin on both NF-kappaB and AP-1 signaling pathways. anagliptin 219-229 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-102 26290634-13 2015 Furthermore, DHI inhibited LPS-induced IkappaBalpha and NF-kappaB p65 phosphorylation. dehydrosoyasaponin I 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 26015438-3 2015 Regarding the molecular mechanism, LPS-induced degradation of IkappaBalpha and phosphorylations of p65, JNK, and p38, as well as NF-kappaB and AP-1 promoter activities, were revealed to be suppressed by incubation with anagliptin, indicating suppressive effects of anagliptin on both NF-kappaB and AP-1 signaling pathways. anagliptin 265-275 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-102 26464629-9 2015 LMWH attenuated LPS-induced hippocampus-dependent cognitive impairments, which was accompanied by decreased hippocampal IL-1beta, malondialdehyde, Toll-like receptor 4, nuclear factor kappa B p65, inducible nitric oxide synthase, cyclooxygenase-2, high mobility group box-1 protein, and IBA1 positive cells, and increased occluding and brain derived neurotrophic factor levels. Heparin, Low-Molecular-Weight 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 192-195 25425548-7 2015 OxyR suppressed the phosphorylation of Akt and JNK and p38 MAPKs and the translocation of NFkappaB p65 subunit into the nucleus. puag-haad 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-102 26283886-12 2015 Mice pretreated with 3-MA before exposure to LPS showed a reduction in p65 phosphorylation, resulting in the accumulation of ubiquitinated IkappaB. 3-methyladenine 21-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 71-74 26178579-7 2015 Compared to the PBS or the NC mice, levels of Bcl-2 mRNA and protein in tumour xenografts were significantly downregulated in p65 siRNA-treated mice. pbs 16-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 126-129 25895149-5 2015 Sinomenine decreased p65 expression in nuclear and increased IkappaBalpha expression in cytoplasm, and these effects were reversed by the alpha7nAChR small interfering RNA as well. sinomenine 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 21-24 26222683-6 2015 Baicalein inhibited the cisplatin-induced expression of iNOS, TNF-alpha, IL-6 and mononuclear cell infiltration and concealed redox-sensitive transcription factor NF-kappaB activation via reduced DNA-binding activity, IkappaBalpha phosphorylation and p65 nuclear translocation in kidneys. baicalein 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 251-254 26222683-6 2015 Baicalein inhibited the cisplatin-induced expression of iNOS, TNF-alpha, IL-6 and mononuclear cell infiltration and concealed redox-sensitive transcription factor NF-kappaB activation via reduced DNA-binding activity, IkappaBalpha phosphorylation and p65 nuclear translocation in kidneys. Cisplatin 24-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 251-254 25975517-9 2015 Eupafolin decreased the TNF-alpha-induced NF-kappaB p65 activation and its nuclear translocation. eupafolin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 52-55 25975517-11 2015 CONCLUSIONS: Eupafolin exerts its anti-inflammatory activity by suppressing the TNF-alpha-induced ICAM-1 expression and subsequent monocyte adhesion via AKT/ERK1/2/JNK phosphorylation and nuclear translocation of NF-kappaB p65. eupafolin 13-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 223-226 26151119-6 2015 Further research demonstrated that procyanidin B2 decreased the expression of TNF-alpha, IL-1beta, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), as well as inhibited the translocation of nuclear factor-kappa B (NF-kappaB) p65 from the cytosol to the nuclear fraction in mouse liver. procyanidin B2 35-49 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 245-248 26094873-0 2015 Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-kappaB/p65 signaling pathway to promote melanoma cell death. Ginsenosides 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 26271975-1 2015 OBJECTIVE: To test a novel gene carrier, named polyethyleneimine nanogel particles (PEI-NP), for delivering the mircroRNA (miRNA) into Kupffer cells (KCs) for silencing the expression of nuclear transcription factor kappaB (NF-kappaB) P65. aziridine 47-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 235-238 26200012-6 2015 Further, ERRalpha was required for the regulation of NF-kappaB signaling by controlling p65 acetylation via maintenance of NAD(+) levels and sirtuin 1 activation. NAD 123-129 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 25987561-8 2015 PO also prevented PA-induced IkappaBalpha degradation, RelA nuclear translocation, NO production, and cytokine secretion. Palmitates 18-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-59 25819340-11 2015 TAMs showed increased nuclear localization of p65 with decreased Nrf2 expression in the nucleus. tams 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 46-49 25887268-9 2015 SND-117 also strongly inhibited the phosphorylation and nuclear translocation of NF-kappaB p65 in FLSCs upon TNF-alpha stimulation. snd-117 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-94 25572867-4 2015 Pre-treatment with delta-amyrone prevented the myeloperoxidase (MPO) activity, production of nitric oxide (NO) in serum, expression of inducible nitric oxide synthase (iNOS) and nuclear factor kappa B (NF-kappaB) p65 protein expression. amyrone 19-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 213-216 25828855-7 2015 As confirmed by the nuclear translocation of p65, tumor necrosis factor alpha and caffeic acid phenethyl ester (CAPE) increased and decreased mCLCA2 promoter activity, respectively, but exhibited modest effects on endogenous mCLCA2 expression in cells in culture medium containing 0.05 mM Ca(2+). caffeic acid phenethyl ester 82-110 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 45-48 25828855-7 2015 As confirmed by the nuclear translocation of p65, tumor necrosis factor alpha and caffeic acid phenethyl ester (CAPE) increased and decreased mCLCA2 promoter activity, respectively, but exhibited modest effects on endogenous mCLCA2 expression in cells in culture medium containing 0.05 mM Ca(2+). caffeic acid phenethyl ester 112-116 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 45-48 25881103-5 2015 Blebbistatin enhanced Akt and GSK3beta phosphorylation and inhibited NF-kappaB p65 nuclear translocation and IkappaBalpha degradation. blebbistatin 0-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 79-82 25881103-10 2015 Importantly, blebbistatin decreased endothelium NMMHC IIA and TF expression, deactivated GSK3beta by inducing its phosphorylation, suppressed p65 nuclear translocation, and inhibited thrombus formation in a mouse deep venous thrombosis model.Our findings provide solid evidence that inhibition of NMMHC II, most likely NMMHC IIA, impedes TF expression and venous thrombosis via Akt/GSK3beta-NF-kappaB signalling pathways in the endothelium both in vitro and in vivo. blebbistatin 13-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 142-145 25572867-5 2015 Analysis of cytokines in gastric tissue and serum of ethanol-induced mice showed the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were decreased by delta-amyrone in response to NF-kappaB p65. Ethanol 53-60 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 217-220 25572867-5 2015 Analysis of cytokines in gastric tissue and serum of ethanol-induced mice showed the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were decreased by delta-amyrone in response to NF-kappaB p65. amyrone 178-191 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 217-220 25858541-7 2015 Chromatin immunoprecipitation assays indicated that C-DIM12 decreased lipopolysaccharide-induced p65 binding to the NOS2 promoter and concurrently enhanced binding of Nurr1 to the p65-binding site. C-DIM12 52-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 97-100 25629551-5 2015 Mechanistically, GSK3beta was sufficient and essential for RelA/p65 phosphorylation, specifically at serine 467, which specifies the expression of selective NFkappaB target molecules, including podocytopathic mediators, but not Bcl-xL. Serine 101-107 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-63 25629551-5 2015 Mechanistically, GSK3beta was sufficient and essential for RelA/p65 phosphorylation, specifically at serine 467, which specifies the expression of selective NFkappaB target molecules, including podocytopathic mediators, but not Bcl-xL. Serine 101-107 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-67 25858541-7 2015 Chromatin immunoprecipitation assays indicated that C-DIM12 decreased lipopolysaccharide-induced p65 binding to the NOS2 promoter and concurrently enhanced binding of Nurr1 to the p65-binding site. C-DIM12 52-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 180-183 25858541-9 2015 Collectively, these data identify C-DIM12 as a modulator of Nurr1 activity that results in inhibition of NF-kappaB-dependent gene expression in glial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. C-DIM12 34-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 226-229 25994935-9 2015 The combination of mechanical strain and icariin stimulation could activate NF-kappaB signaling pathway by increasing the expression of IkappaB alpha, P-IkappaB-alpha, p65, P-p65 (P < 0.01). icariin 41-48 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 168-171 25959124-8 2015 RESULTS: RSV treatment decreased leukocyte/platelet adhesion and E-selectin/ICAM-1 expression with increased SIRT-1 expression in septic ob/ob and WT mice, decreased E-selectin/ICAM-1 expression via increased SIRT-1 expression, and decreased AC-p65 expression in HUVEC. Resveratrol 9-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 245-248 25843059-6 2015 Using qRT-PCR as a follow up to the array, we demonstrated that didox suppresses LPS-induced mRNA levels of iNOS, IL-6, IL-1, TNF-alpha, NF-kappabeta (p65), and p38-alpha, after 24h of treatment. 3,4-dihydroxybenzohydroxamic acid 64-69 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 151-154 25843059-9 2015 Moreover, we demonstrate that nuclear translocation of NF-kappabeta (p65) in response to LPS is inhibited by didox. 3,4-dihydroxybenzohydroxamic acid 109-114 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-72 25902336-5 2015 Furthermore, we demonstrated that AC inhibited the phosphorylation of IkappaBalpha, nuclear factor-kappaB (NF-kappaB) p65, inhibitor of nuclear factor kappa-B kinase-alpha (IKK-alpha) and inhibitor of nuclear factor kappa-B kinase-beta (IKKbeta) in LPS-induced inflammation in A549 cells. acteoside 34-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-171 26137027-6 2015 It was demonstrated that the histological acuteness of AOM/DSS-induced CAC was significantly reduced following the administration of PT, resulting in decreased NF-kappaB p65 expression levels via a blockade of phosphorylation and subsequent degradation of inhibitor of kappaB-alpha (IkappaBalpha). Dextran Sulfate 59-62 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 170-173 25915426-9 2015 In molecular studies, elevated O-GlcNAc levels were shown to enhance the activation of NF-kappaB signaling through increasing the binding of RelA/p65 to its target promoters. o-glcnac 31-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 146-149 25915426-10 2015 We also found that Thr-322 and Thr352 in the p65-O-GlcNAcylation sites are critical for p65 promoter binding. Threonine 19-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 45-48 25915426-10 2015 We also found that Thr-322 and Thr352 in the p65-O-GlcNAcylation sites are critical for p65 promoter binding. Threonine 19-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 25311527-9 2015 High-dose liquiritigenin treatment group showed significant decreases in TNBS-induced phosphorylation of IKKbeta, p65, and IkappaB-alpha. liquiritigenin 10-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-117 25311527-9 2015 High-dose liquiritigenin treatment group showed significant decreases in TNBS-induced phosphorylation of IKKbeta, p65, and IkappaB-alpha. Trinitrobenzenesulfonic Acid 73-77 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-117 25641276-11 2015 In STZ-induced NPDR mice, Andro abrogated the nuclear translocation of nuclear factor kappaB (NF-kappaB) p65 and early growth response-1 (Egr-1), and reduced the increased phospho-NF-kappaBp65, -inhibitor of kappa B (IkappaB), and -IkappaB kinase (IKK). Streptozocin 3-6 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 105-108 25766329-4 2015 Losartan treatment was associated with significantly increased serum tumor necrosis factor alpha (TNF-alpha) level, p65 nuclei accumulation, and decreased muscle IkappaB-beta protein level, indicating NFkappaB activation. Losartan 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 116-119 25517107-6 2015 RESULTS: SPC-RelA mice showed significant increases in lung inflammation and injury following LPS injection with increased neutrophil recruitment as compared to wild type and saline treated controls. Sodium Chloride 175-181 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 13-17 25651848-4 2015 Resveratrol also inhibited the translocation of high-mobility group box 1 (HMGB1) from the nucleus to the cytoplasm and of nuclear transcription factor kappa-B (NF-kappaB) p65 from the cytoplasm to the nucleus; it suppressed the phosphorylation of IkappaBalpha. Resveratrol 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 172-175 25466609-10 2015 Phosphorylation of NF-kappaB p65 was significantly reduced in mice treated with triptolide and dexamethasone. triptolide 80-90 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 29-32 25466609-10 2015 Phosphorylation of NF-kappaB p65 was significantly reduced in mice treated with triptolide and dexamethasone. Dexamethasone 95-108 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 29-32 25680189-5 2015 Macrophages differentiated in the presence of SC-560 (COX-1 inhibitor), NS-398 (COX-2 inhibitor) or indomethacin (COX-1/2 inhibitor) for 7 days produced more TNFalpha or IL-12p70 with enhanced p65/IkappaB phosphoylation. SC 560 46-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 193-196 25609694-6 2015 Moreover, recent studies revealed that RelA/p65 directly binds to the peroxisome proliferator-activated receptor-gamma coactivator1alpha (PGC1alpha) to decrease transcriptional activation of the PGC1alpha target gene PDK4, whose gene product inhibits pyruvate dehydrogenase (PDH), a key regulator of TCA cycle flux. Trichloroacetic Acid 300-303 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 39-43 25609694-6 2015 Moreover, recent studies revealed that RelA/p65 directly binds to the peroxisome proliferator-activated receptor-gamma coactivator1alpha (PGC1alpha) to decrease transcriptional activation of the PGC1alpha target gene PDK4, whose gene product inhibits pyruvate dehydrogenase (PDH), a key regulator of TCA cycle flux. Trichloroacetic Acid 300-303 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 44-47 25680189-5 2015 Macrophages differentiated in the presence of SC-560 (COX-1 inhibitor), NS-398 (COX-2 inhibitor) or indomethacin (COX-1/2 inhibitor) for 7 days produced more TNFalpha or IL-12p70 with enhanced p65/IkappaB phosphoylation. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 72-78 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 193-196 25680189-5 2015 Macrophages differentiated in the presence of SC-560 (COX-1 inhibitor), NS-398 (COX-2 inhibitor) or indomethacin (COX-1/2 inhibitor) for 7 days produced more TNFalpha or IL-12p70 with enhanced p65/IkappaB phosphoylation. Indomethacin 100-112 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 193-196 25304310-10 2015 Western blot analysis revealed an increased protein expressions of COX-2, STAT-3 NF-kB p65 and PARP-1 and decreased IkB-alpha and IL-4 in the Cg group. Carrageenan 142-144 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 87-90 25902030-9 2015 RESULTS: Administration of pectic polysaccharides significantly reduced the severity of DSS-induced colitis as assessed by DAI and histological score, and resulted in down regulation of MPO activity and NF- kappa B p65 expression and subsequent degradation of I kappa B protein, strikingly reduced the production of TNF- a and IL-17. Polysaccharides 34-49 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 215-218 25902030-9 2015 RESULTS: Administration of pectic polysaccharides significantly reduced the severity of DSS-induced colitis as assessed by DAI and histological score, and resulted in down regulation of MPO activity and NF- kappa B p65 expression and subsequent degradation of I kappa B protein, strikingly reduced the production of TNF- a and IL-17. Dextran Sulfate 88-91 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 215-218 25539811-0 2015 Chronic morphine-induced microRNA-124 promotes microglial immunosuppression by modulating P65 and TRAF6. Morphine 8-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-93 25539811-5 2015 Either morphine or inhibition of acetylcholine significantly promotes upregulation of microRNA-124 (miR-124) in microglia, bone marrow-derived macrophages, and the mouse brain, where miR-124 mediates morphine inhibition of the innate immunity by directly targeting a subunit of NF-kappaB p65 and TNFR-associated factor 6 (TRAF6). Morphine 7-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 288-291 25539811-5 2015 Either morphine or inhibition of acetylcholine significantly promotes upregulation of microRNA-124 (miR-124) in microglia, bone marrow-derived macrophages, and the mouse brain, where miR-124 mediates morphine inhibition of the innate immunity by directly targeting a subunit of NF-kappaB p65 and TNFR-associated factor 6 (TRAF6). Acetylcholine 33-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 288-291 25539811-5 2015 Either morphine or inhibition of acetylcholine significantly promotes upregulation of microRNA-124 (miR-124) in microglia, bone marrow-derived macrophages, and the mouse brain, where miR-124 mediates morphine inhibition of the innate immunity by directly targeting a subunit of NF-kappaB p65 and TNFR-associated factor 6 (TRAF6). Morphine 200-208 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 288-291 25539811-7 2015 Moreover, acute morphine treatment transiently upregulated the expression of p65 and phospho-p65 in both nucleus and cytoplasm priming the expression of miR-124, whereas long exposure of morphine maintained miR-124 expression, which inhibited p65- and TRAF6-dependent TLR signaling. Morphine 16-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-80 25539811-7 2015 Moreover, acute morphine treatment transiently upregulated the expression of p65 and phospho-p65 in both nucleus and cytoplasm priming the expression of miR-124, whereas long exposure of morphine maintained miR-124 expression, which inhibited p65- and TRAF6-dependent TLR signaling. Morphine 16-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 93-96 25539811-7 2015 Moreover, acute morphine treatment transiently upregulated the expression of p65 and phospho-p65 in both nucleus and cytoplasm priming the expression of miR-124, whereas long exposure of morphine maintained miR-124 expression, which inhibited p65- and TRAF6-dependent TLR signaling. Morphine 16-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 93-96 25539811-7 2015 Moreover, acute morphine treatment transiently upregulated the expression of p65 and phospho-p65 in both nucleus and cytoplasm priming the expression of miR-124, whereas long exposure of morphine maintained miR-124 expression, which inhibited p65- and TRAF6-dependent TLR signaling. Morphine 187-195 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-80 25173887-10 2015 Magnolol declined the phosphorylation of IkappaBalpha, p65, p38, ERK, and JNK in LPS-stimulated MMECs. magnolol 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 25404465-9 2015 Finally, RT-PCR data revealed that olaparib downregulates the LPS-induced expression of NF-kappaB-dependent genes namely TNF-alpha, IL-1beta, and VCAM-1 in the lungs without altering the expression of total p65NF-kappaB. olaparib 35-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 207-219 25472953-3 2015 The present study demonstrated that R1 alleviated the severity of dextran sulfate sodium-induced colitis in mice by decreasing the activity of myeloperoxidase, the production of cytokines, the expression of proinflammatory genes, and the phosphorylation of IkappaB kinase, IkappaBalpha, and p65 in the colon. Dextran Sulfate 66-88 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 291-294 25445046-6 2015 Furthermore, LPS-mediated DNA binding of p65 and p50 to the NF-kappaB binding site of the iNOS promoter was inhibited by HBU-199 and HBU-200, whereas dopamine and ALA did not inhibit LPS-induced NF-kappaB activation and IkappaB-alpha phosphorylation. Dopamine 150-158 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 41-44 24854198-6 2015 Concomitantly, VPA alleviated the levels of p65 NF-kappaB phosphorylation and enhanced the levels of acetyl-H3, Bcl-2, and phospho-glycogen synthase kinase (GSK)-3beta that occurred in the hippocampus of APP/PS1 transgenic mice. Valproic Acid 15-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 44-57 25446596-7 2015 The nuclear translocation of NF-kappaB (p65 and p50) was suppressed by Pc-ME. 2,4-diamino-5-cyclohexyl-6-methylpyrimidine 71-76 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-43 25445046-6 2015 Furthermore, LPS-mediated DNA binding of p65 and p50 to the NF-kappaB binding site of the iNOS promoter was inhibited by HBU-199 and HBU-200, whereas dopamine and ALA did not inhibit LPS-induced NF-kappaB activation and IkappaB-alpha phosphorylation. Thioctic Acid 163-166 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 41-44 25449038-7 2015 In addition, hinokitiol suppressed the translocation of p65 NF-kappaB from the cytosol to the nucleus, suggesting reduced NF-kappaB activation. beta-thujaplicin 13-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 56-69 25242651-7 2015 Furthermore, inclusion of BAY 11-7028, an inhibitor of NFkappaB activation, reduced nuclear translocation of RelA and fusion in WT macrophages. bay 11-7028 26-37 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-113 25448849-4 2015 We found that triptolide inhibited osteoclastogenesis and bone resorption, as well as RANKL-induced NF-kB activities as monitored by luciferase reporter gene assays and the nuclear translocation of p65. triptolide 14-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 198-201 25559736-7 2015 One of the salient observations of this study was a coupled increase in the expression of renal, relA, NF-kB2, and p53 genes and proteins during folic acid induced AKI (FA AKI). Folic Acid 145-155 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 97-101 25455454-8 2015 Moreover, BLM-induced pulmonary nuclear factor kappa B (NF-kappaB) p65 activation was blocked by PBA. Bleomycin 10-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 67-70 25654487-10 2015 Furthermore, irisflorentin significantly interfered with LPS-induced activation of IkappaB kinase, c-Jun N-terminal kinase, and p38, as well as the nuclear translocation of NF-kappaB p65. irisflorentin 13-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 183-186 26227399-5 2015 (+)-catechin attenuated LPS-induced nuclear factor-kappaB (NF-kappaB) p65 nuclear translocation via the inhibition of IkappaB-alpha phosphorylation. Catechin 0-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 25908255-4 2015 The administration of Fasudil exhibited neuroprotective effects against the dopaminergic neurons and improved the motor function recovery in the MPTP-PD mice, accompanied by the suppression of inflammatory responses (IL-1beta, TNF-alpha, NF-kappaB-p65 and TLR-2), and oxidative stress (iNOS and gp91Phox), which might be associated with the inhibition of ROCK and GSK-3beta activity. fasudil 22-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 248-251 25355930-9 2015 LY2409881 suppressed the activity of the NF-kappaB subunit p65 in lymphoma cells treated by the HDAC inhibitor romidepsin, underlying a potential mechanism of the marked synergy observed of these two drugs. LY2409881 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-62 25287052-7 2015 Further, we observed that, in vitro, Fasudil inhibited the capacity of encephalitogenic MNCs to adoptively transfer EAE and reduced TLR-4/p-NF-kappaB/p65 and inflammatory cytokines in spinal cords. fasudil 37-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 150-153 25838833-5 2015 BHSST significantly suppressed the protein expression of toll-like receptor 4 (TLR4) and phosphorylated nuclear factor-kappa B (NF-kappaB) p65 in RAW 264.7 cells. bhsst 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 139-142 25479726-10 2015 Further results showed that paeoniflorin pretreatment was capable of suppressing the activation of the NF-kappaB pathway by inhibiting IkappaBalpha kinase and p65 phosphorylation in Con A-induced liver injury. peoniflorin 28-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 159-162 24730395-10 2015 Further, the reduced secretion of IL-1beta correlated with reduced nuclear translocation of nuclear factor (NF)-kappaB p65, starting at exposure of pMPhi to 0 5 Gy of X-irradiation. pmphi 148-153 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-122 25563365-5 2015 Compared to the PBS or the NC mice, levels of Bax mRNA and protein in tumor xenografts were significantly upregulated in p65 siRNA-treated mice. Lead 16-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-124 26354372-7 2015 In the C3H/HeJ mice, stimulation with OVA or LPS increased p65 and p52 binding activity and the combination of exposure to toluene and OVA significantly increased the DNA binding activities of the p65 and p52 in the lung. Toluene 123-130 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-62 26354372-7 2015 In the C3H/HeJ mice, stimulation with OVA or LPS increased p65 and p52 binding activity and the combination of exposure to toluene and OVA significantly increased the DNA binding activities of the p65 and p52 in the lung. Toluene 123-130 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 197-200 26600673-4 2015 Knockdown of TRAF6 by siTRAF6 significantly attenuated agonist-CD137mAb induced increase of NF-kappaB p65 and NFATc1 in VSMCs. sitraf6 22-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-105 26540118-6 2015 Furthermore, we demonstrated that TB inhibited the Toll-like receptor-2 (TLR2), Toll-like receptor-4 (TLR4), myeloid differentiation primary response gene-88 (MyD88), nuclear factor-kappaB (NF-kappaB) p65 in LPS-induced ALI. timosaponin B-II 34-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 201-204 26783471-7 2015 Moreover, JSH-23, an inhibitor of NF-kappaB p65 nuclear translocation, counteracted both the proliferation and differentiation changes seen in MMP-1 tg-derived NPCs. 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine 10-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 44-47 26329008-6 2015 In AMJ2-C11 cells, quercetin also attenuated the TLR7-induced CD40 expression; attenuated the translocation of p65; induced translocation of Nrf2 from cytosol to nucleus; and induced heme oxygenase (HO)-1 expression. Quercetin 19-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 111-114 26075036-5 2015 In addition, allicin was capable of reducing the activation and nuclear accumulation of signal transducer and activator of transcription 3 (STAT3), thereby preventing degradation of the inhibitory protein IkappaB and inducing inhibition of the nuclear translocation of nuclear factor (NF)-kappaB-p65 in the colonic mucosa. allicin 13-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 296-299 25034832-6 2014 Oxymatrine inhibited the phosphorylation of NF-kappaB p65 and IkappaB in NF-kappaB signal pathway and reduced the phosphorylation of p38, ERK, and JNK in mitogen-activated protein kinase (MAPKs) signal pathway. oxymatrine 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 54-57 24854163-7 2014 Furthermore, wogonoside inhibited the TLR4 expression and the phosphorylation of NF-kappaB p65, and IkappaB induced by LPS. wogonoside 13-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-94 24912813-4 2014 The results showed that Thd significantly improved the survival rate, reduced the infiltration of inflammatory cells and cytokine (e.g., IL-6, TNF-alpha) and chemokine (e.g., RANTES, IP-10) levels, and inhibited activated p-NFkappaB p65 in infected mice. Thalidomide 24-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 233-236 25664028-0 2014 Intervention of transforming pulmonary fibrosis with NF-kappaB p65 antisense oligonucleotide. Oligonucleotides 77-92 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 63-66 25664028-8 2014 Meanwhile, they were reduced significantly through the intervention of NF-kappaB p65 antisense oligonucleotide in the test group (P < 0.05). Oligonucleotides 95-110 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 81-84 25664028-10 2014 CONCLUSION: our study suggests the potential in prevention of bleomycin-induced pulmonary fibrosis with NF-kappaB p65 antisense oligonucleotide. Bleomycin 62-71 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-117 25168307-8 2014 Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p < 0.05). 1-Butanol 29-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 220-223 25168307-8 2014 Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p < 0.05). aq 35-37 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 220-223 25454762-5 2014 Isobutyrylshikonin also suppressed LPS-induced DNA-binding activity of nuclear transcription factor-kappaB (NF-kappaB), by inhibiting the nuclear translocation of p50 and p65 in addition to blocking the phosphorylation and degradation of IkappaBalpha. isobutyrylshikonin 0-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 171-174 25168307-8 2014 Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p < 0.05). Succinic Acid 39-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 220-223 25057925-4 2014 Analysis of NF-kappaB activation pathway showed that TG2 knockdown was associated with inhibition of thrombin-induced DNA binding as well as serine phosphorylation of RelA/p65, a crucial event that controls transcriptional capacity of the DNA-bound RelA/p65. Serine 141-147 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 167-171 25057925-4 2014 Analysis of NF-kappaB activation pathway showed that TG2 knockdown was associated with inhibition of thrombin-induced DNA binding as well as serine phosphorylation of RelA/p65, a crucial event that controls transcriptional capacity of the DNA-bound RelA/p65. Serine 141-147 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 172-175 25393510-4 2014 Berteroin inhibited LPS-induced degradation of inhibitor of kappaBalpha (IkappaBalpha) and nuclear factor-kappaB p65 translocation to the nucleus and DNA binding activity. berteroin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 113-116 25242730-8 2014 Moreover, nuclear localization of RelA in knee joints was significantly inhibited in NAHNP treatment, indicating down-regulation of the NF-kappaB signaling pathway. nahnp 85-90 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 34-38 25550915-0 2014 Baicalin down regulates the expression of TLR4 and NFkB-p65 in colon tissue in mice with colitis induced by dextran sulfate sodium. Dextran Sulfate 108-130 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 56-59 25387351-4 2014 The sulfated chitosan oligosaccharides also suppressed inducible nitric oxide synthase (iNOS), phosphorylation of JNK and translocation of p65, a subunit of NF-kappaB, into the nucleus by inhibiting degradation of IkappaB-alpha. Chitosan 13-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 139-142 25387351-4 2014 The sulfated chitosan oligosaccharides also suppressed inducible nitric oxide synthase (iNOS), phosphorylation of JNK and translocation of p65, a subunit of NF-kappaB, into the nucleus by inhibiting degradation of IkappaB-alpha. Oligosaccharides 22-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 139-142 25480515-8 2014 RESULTS: The data showed that treatment with the tectorigenin markedly attenuated the inflammatory cell numbers in the BALF, decreased nuclear factor NF-kappaB p65 mRNA level and protein level in the lungs, and improved SOD activity and inhibited MPO activity. tectorigenin 49-61 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 160-163 25038318-6 2014 Furthermore, NF-kappaB activation was inhibited by niacin through blocking the phosphorylation of NF-kappaB p65 and IkappaBalpha. Niacin 51-57 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 108-111 24988983-5 2014 In addition, both the NF-kappaB subunit p65 and the AP-1-related c-jun were markedly inhibited by samidin. samidin 98-105 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-43 25194678-5 2014 DSS-induced degradation of inhibitory kappaBalpha (IkappaBalpha) and the phosphorylation of nuclear factor-kappa B (NF-kappaB) p65 as well as the mRNA expression of pro-inflammatory mediators (inducible NO synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1), TNF-alpha, interleukin-1beta (IL-1beta) and IL-6) in the colon were also downregulated by mangiferin treatment. Dextran Sulfate 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 127-130 25175917-9 2014 Like curcumin, DEC prevents NF-kappaB activation by reducing NF-kappaB p65 phosphorylation and IkappaBalpha degradation. Curcumin 5-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 71-74 25618401-9 2014 Quetiapine inhibits the activation of nuclear factor kappa B p65 pathway in both transgenic mice and primary microglia stimulated by Abeta1-42. Quetiapine Fumarate 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 61-64 25314304-5 2014 The nuclear translocation of NF-kappaB and the phosphorylation level of p65, p38 and JNK MAP kinase pathways were also inhibited by PQQ in LPS stimulated primary microglia cells. PQQ Cofactor 132-135 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 25296021-6 2014 The role of the NFkappaB pathway in nicotine-induced NGF expression was investigated by measuring NFkappaB nuclear translocation, transcriptional activity, chromatin immunoprecipitation assays, and si-p65 NFkappaB knockdown. Nicotine 36-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 201-204 25296021-9 2014 Nicotine increased NGF secretion in lung fibroblasts in vitro in a dose-dependent manner and stimulated NFkappaB nuclear translocation, p65 binding to the NGF promoter, and NFkappaB transcriptional activity. Nicotine 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-139 25146101-6 2014 Also, Western blotting analysis indicated that NF-kappaB p65 expression was significantly attenuated in the mucosa in colitis mice with GdCl3 treatment. gadolinium chloride 136-141 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 57-60 25034806-9 2014 Furthermore, veratric acid inhibited the phosphorylation of NF-kappaB p65 and IkappaB. veratric acid 13-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 25121552-8 2014 Treatment with enalapril and ASS led to significant downregulation of known target genes Vegf and Rela at RNA level. Enalapril 15-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 98-102 25173422-4 2014 Also Betulin suppressed the phosphorylation of nuclear factor-kappaB (NF-kappaB) p65 protein in LPS-stimulated RAW 264.7 cells. betulin 5-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 81-84 25119102-7 2014 MMME also suppressed the expression of COX-2, iNOS, and NF-kappaB p65, suggesting that MMME could affect the expression of inflammation related cytokines and proteins through the deregulation of NF-kappaB. mmme 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 24743918-7 2014 Furthermore, kaempferol suppressed the phosphorylation of nuclear factor-kappaB (NF-kappaB) p65 subunit and the degradation of its inhibitor IkappaBalpha. kaempferol 13-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 92-95 25044948-8 2014 Pretreatment with PPARgamma inhibitor (GW9662) abolished the inhibitory effect of DHA (100 muM) on LA-induced IkappaB degradation, p65 translocation, and MCP-1 expression in ARPE-19 cells (p < 0.05), as well as tube formation in RF6A. 2-chloro-5-nitrobenzanilide 39-45 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 131-134 25044948-8 2014 Pretreatment with PPARgamma inhibitor (GW9662) abolished the inhibitory effect of DHA (100 muM) on LA-induced IkappaB degradation, p65 translocation, and MCP-1 expression in ARPE-19 cells (p < 0.05), as well as tube formation in RF6A. Docosahexaenoic Acids 82-85 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 131-134 25172655-7 2014 Alcohol activation of NF-kappaB allows for nuclear translocation of the NF-kappaB subunit p65 and expression of pro-inflammatory mediators. Alcohols 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-93 25059280-9 2014 Among the compounds, oleanolic acid significantly decreased MafK expression and MafK-mediated p65 acetylation. Oleanolic Acid 21-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 94-97 24913217-4 2014 Using two different models (ulcerative colitis like and Crohn"s disease like) of experimental IBD in mice, we demonstrated that isorhamnetin abrogated inflammation through inhibiting the activity of myeloperoxidase, the levels of TNF-alpha and IL-6, the mRNA expression of proinflammatory mediators (iNOS, ICAM-1, COX2, TNF-alpha, IL-2 and IL-6) and the phosphorylation of IkappaBalpha and NF-kappaB p65. 3-methylquercetin 128-140 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 400-403 24142484-4 2014 Expression of exogenous p50 and p65 subunits of NF-kappaB conferred partial protection on transfected GL261 cells against curcumin insult, indicating that NF-kappaB played a key role in protecting glioblastoma cells. Curcumin 122-130 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 32-35 24796965-9 2014 From a mechanistic view, daumone reduced the phosphorylation of the IkappaBalpha and upregulation of Rela and Nfkbia mRNA in the livers of old mice. ascr#1 25-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-105 24845796-7 2014 PARP-1 inhibition 5-AIQ treatment significantly attenuated the severity of AIA, reduced the arthritis scores, a substantial reduction in the levels of T cell subsets, IL-17A, NF-kB p65, GITR expressing cells, and as well as the pro-inflammatory mediators. 5-aminoisoquinolinone 18-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 181-184 25175164-4 2014 The nuclear localization and interaction between transcriptional co-activator p300 and NF-kappaB p50/p65 and their binding to COX-2 promoter were analyzed after treatment with CS-6. 1-hexene 176-180 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 25175164-10 2014 Moreover, CS-6 markedly down-regulated the protein levels of COX-2 and phosphorylated p65 NF-kappaB in tumor tissues of the xenograft mice, and inhibited tumor weight and size. 1-hexene 10-14 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 86-89 24993070-6 2014 Further study showed that chronic asthma increased the expressions of TLR4 and p65/NFkappaB in the brain, which could be reversed by budesonide treatment. Budesonide 133-143 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 79-82 25089961-5 2014 Icariin also showed properties in inhibiting the phosphorylation of NF-kappaB p65 protein and blocking the degradation of IKappaB-alpha protein. icariin 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 78-81 24706025-6 2014 Additionally, Western blot analysis showed that triptolide inhibited the phosphorylation of inhibitor-kappa B kinase-alpha (IkappaB-alpha), p65, nuclear factor kappa B (NF-kappaB), p38, extracellular receptor kinase (ERK), and Jun N-terminal kinase (JNK) and the expression of Toll-like receptor 4 (TLR4) caused by LPS. triptolide 48-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 140-143 25050617-5 2014 In vivo, pharmacological inhibition of TAK1 with 5Z-7-oxozeaenol blocked the injury-induced phosphorylation of both TAK1 (Thr187) and NF-kB/p65 (Ser536), associated with marked inhibition of superoxide production, 3-nitrotyrosine, and MCP-1 in the injured arteries. 5-7-oxo-zeaenol 49-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 140-143 24880493-5 2014 Furthermore, sulforaphane inhibited TNF-alpha-induced nuclear factor (NF)-kappaB transcriptional activity, Inhibitor of NF-kappaB alpha (IkappaBalpha) degradation and subsequent NF-kappaB p65 nuclear translocation in endothelial cells, suggesting that sulforaphane can inhibit inflammation by suppressing NF-kappaB signaling. sulforaphane 13-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 188-191 24835302-8 2014 Western blot analysis showed that the expressions of IkB, nuclear p65, cyclooxygenase 2 (COX-2) and p-ERK1/2 were down-regulated by curcumin in vitro. Curcumin 132-140 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 24835302-11 2014 Curcumin inhibition of COX-2, p65 expression and ERK1/2 activity in NSCLC cells was associated with decreased survival and increased induction of apoptosis. Curcumin 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 30-33 25080336-10 2014 Progesterone suppressed LPS-induced NF-kappaB activation by decreasing inhibitory kappaBalpha and NF-kappaB p65 phosphorylation and p65 nuclear translocation. Progesterone 0-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 108-111 25080336-10 2014 Progesterone suppressed LPS-induced NF-kappaB activation by decreasing inhibitory kappaBalpha and NF-kappaB p65 phosphorylation and p65 nuclear translocation. Progesterone 0-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 132-135 25050617-5 2014 In vivo, pharmacological inhibition of TAK1 with 5Z-7-oxozeaenol blocked the injury-induced phosphorylation of both TAK1 (Thr187) and NF-kB/p65 (Ser536), associated with marked inhibition of superoxide production, 3-nitrotyrosine, and MCP-1 in the injured arteries. Superoxides 191-201 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 140-143 25050617-5 2014 In vivo, pharmacological inhibition of TAK1 with 5Z-7-oxozeaenol blocked the injury-induced phosphorylation of both TAK1 (Thr187) and NF-kB/p65 (Ser536), associated with marked inhibition of superoxide production, 3-nitrotyrosine, and MCP-1 in the injured arteries. 3-nitrotyrosine 214-229 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 140-143 24952939-3 2014 Here, we show that mice with keratinocyte-restricted p65/RelA deficiency were resistant to 7, 12-dimethylbenz(a)anthracene (DMBA)-/12-O-tetra decanoylphorbol-13 acetate (TPA)-induced skin carcinogenesis. 7, 12-dimethylbenz 91-109 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 24608443-6 2014 Inhibition of AGE formation in db/db mice by pyridoxamine treatment attenuated proteinuria and podocyte injury, restored SIRT1 expression, and reduced p65 and STAT3 acetylation. Pyridoxamine 45-57 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 151-154 24608443-8 2014 Treatment of db/db mice with a bromodomain and extraterminal (BET)-specific bromodomain inhibitor (MS417) which blocks acetylation-mediated association of p65 and STAT3 with BET proteins, attenuated proteinuria, and kidney injury. MS417 99-104 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 155-158 24952939-3 2014 Here, we show that mice with keratinocyte-restricted p65/RelA deficiency were resistant to 7, 12-dimethylbenz(a)anthracene (DMBA)-/12-O-tetra decanoylphorbol-13 acetate (TPA)-induced skin carcinogenesis. 7, 12-dimethylbenz 91-109 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 57-61 24952939-3 2014 Here, we show that mice with keratinocyte-restricted p65/RelA deficiency were resistant to 7, 12-dimethylbenz(a)anthracene (DMBA)-/12-O-tetra decanoylphorbol-13 acetate (TPA)-induced skin carcinogenesis. anthracene 112-122 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 24952939-3 2014 Here, we show that mice with keratinocyte-restricted p65/RelA deficiency were resistant to 7, 12-dimethylbenz(a)anthracene (DMBA)-/12-O-tetra decanoylphorbol-13 acetate (TPA)-induced skin carcinogenesis. anthracene 112-122 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 57-61 24952939-3 2014 Here, we show that mice with keratinocyte-restricted p65/RelA deficiency were resistant to 7, 12-dimethylbenz(a)anthracene (DMBA)-/12-O-tetra decanoylphorbol-13 acetate (TPA)-induced skin carcinogenesis. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 124-128 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 24952939-3 2014 Here, we show that mice with keratinocyte-restricted p65/RelA deficiency were resistant to 7, 12-dimethylbenz(a)anthracene (DMBA)-/12-O-tetra decanoylphorbol-13 acetate (TPA)-induced skin carcinogenesis. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 124-128 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 57-61 24952939-3 2014 Here, we show that mice with keratinocyte-restricted p65/RelA deficiency were resistant to 7, 12-dimethylbenz(a)anthracene (DMBA)-/12-O-tetra decanoylphorbol-13 acetate (TPA)-induced skin carcinogenesis. Tetradecanoylphorbol Acetate 170-173 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 24952939-3 2014 Here, we show that mice with keratinocyte-restricted p65/RelA deficiency were resistant to 7, 12-dimethylbenz(a)anthracene (DMBA)-/12-O-tetra decanoylphorbol-13 acetate (TPA)-induced skin carcinogenesis. Tetradecanoylphorbol Acetate 170-173 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 57-61 24952939-5 2014 In addition, lack of p65 strongly inhibited TPA-induced epidermal hyperplasia and skin inflammation by suppressing the expression of proinflammatory cytokines and chemokines by epidermal keratinocytes. Tetradecanoylphorbol Acetate 44-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 21-24 24952939-6 2014 Therefore, p65-dependent NF-kappaB signalling in keratinocytes promotes DMBA-/TPA-induced skin carcinogenesis by protecting keratinocytes from DNA damage-induced death and facilitating the establishment of a tumour-nurturing proinflammatory microenvironment. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 72-76 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 11-14 24952939-6 2014 Therefore, p65-dependent NF-kappaB signalling in keratinocytes promotes DMBA-/TPA-induced skin carcinogenesis by protecting keratinocytes from DNA damage-induced death and facilitating the establishment of a tumour-nurturing proinflammatory microenvironment. Tetradecanoylphorbol Acetate 78-81 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 11-14 24887420-7 2014 GSNO"s nitrosylating ability was reflected in the induced nitrosylation of various known proteins including NFkappaB p65, Akt and EGFR. S-Nitrosoglutathione 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-120 24747094-5 2014 Mechanistically, daphnetin blunted the transcriptional activity of nuclear factor-kappa B (NF-kappaB), which was associated with the down-regulation of the phosphorylation and nuclear translocation of RelA/p65. daphnetin 17-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 201-205 24747094-5 2014 Mechanistically, daphnetin blunted the transcriptional activity of nuclear factor-kappa B (NF-kappaB), which was associated with the down-regulation of the phosphorylation and nuclear translocation of RelA/p65. daphnetin 17-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 206-209 24585461-8 2014 GA intake dose-dependently suppressed renal expression of nuclear factor kappa B (NF-kappaB) p65 and p-p38, decreased reactive oxygen species production, and retained glutathione content (p < 0.05). Glycyrrhizic Acid 0-2 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 93-96 24977407-8 2014 CONCLUSIONS/SIGNIFICANCE: Among all synthesized compounds tested, we found that complex [Ni(H2L1)(PPh3)]Cl (5) (complex 5), potently inhibited IkappaBalpha degradation and NF-kappaB p65 nuclear translocation in LPS-stimulated RAW264.7 cells as well as TNFalpha-stimulated HeLa S3 cells. [ni(h2l1)(pph3)]cl 88-106 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 182-185 24892995-9 2014 Remarkably, NAC supplementation not only ameliorated TCE-induced nitrosative stress as evident from decreased iNOS, NT, nitrated proteins, NF-kappaB p65 activation and increased GSH levels, but also the markers of autoimmunity, as evident from decreased levels of autoantibodies in the sera. Acetylcysteine 12-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 149-152 24789089-5 2014 Additionally, western blot analysis showed that triptolide inhibited the LPS-induced phosphorylation of nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor-alpha and nuclear factor kappa-light-chain-enhancer of activated B cells-p65 (NF-kappaB p65) and the expression of Toll-like receptor 4 (TLR4). triptolide 48-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 254-257 24789089-5 2014 Additionally, western blot analysis showed that triptolide inhibited the LPS-induced phosphorylation of nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor-alpha and nuclear factor kappa-light-chain-enhancer of activated B cells-p65 (NF-kappaB p65) and the expression of Toll-like receptor 4 (TLR4). triptolide 48-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 269-272 24690200-13 2014 Pharmacological inhibition of STAT3 by AG490 reversed the inactivation of p65 and anti-inflammatory effects of HSYA. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 39-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-77 24894401-5 2014 METHODS: The effect of hyperglycemia and Sirt1 activator, resveratrol, on acetylation of p65 and its binding at MMP-9 promoter-and mitochondrial damage and apoptosis-was assessed in the retinal endothelial cells. Resveratrol 58-69 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 89-92 24894401-8 2014 RESULTS: High glucose decreased Sirt1 activity and increased p65 acetylation, and resveratrol prevented increase in p65 acetylation, binding of p65 at MMP-9 promoter and MMP-9 activation, mitochondria damage, and cell apoptosis. Resveratrol 82-93 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 116-119 24894401-8 2014 RESULTS: High glucose decreased Sirt1 activity and increased p65 acetylation, and resveratrol prevented increase in p65 acetylation, binding of p65 at MMP-9 promoter and MMP-9 activation, mitochondria damage, and cell apoptosis. Resveratrol 82-93 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 116-119 24286322-3 2014 Salicortin significantly suppressed LPS-induced signal cascades of NF-kappaB activation, such as IKK activation, IkappaBalpha phosphorylation and p65 phosphorylation in RAW 264.7 cells. salicortin 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 146-149 24301524-4 2014 The proteasome inhibitor bortezomib repressed the transcription of Notch1 and downstream effectors including Hes1, GATA3, RUNX3 and nuclear factor-kappaB (NF-kappaB) (p65 and p50), coincided with downregulation of the major transactivator Sp1 and its dissociation from Notch1 promoter. Bortezomib 25-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 167-170 23686307-1 2014 Acetylation of the RelA subunit of NF-kappaB at lysine-310 regulates the transcriptional activation of NF-kappaB target genes and contributes to maintaining constitutively active NF-kappaB in tumors. Lysine 48-54 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 19-23 24635351-10 2014 Finally, inhibition of RelA with the chemical inhibitors sulfasalazine and 4-Methyl-N1-(3-phenylpropyl)benzene-1,2-diamine (JSH-23) in tanycyte cell cultures prevented the LPS-induced D2 increase. Sulfasalazine 57-70 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 23-27 24635351-10 2014 Finally, inhibition of RelA with the chemical inhibitors sulfasalazine and 4-Methyl-N1-(3-phenylpropyl)benzene-1,2-diamine (JSH-23) in tanycyte cell cultures prevented the LPS-induced D2 increase. 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine 75-122 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 23-27 24462571-2 2014 Herein, we showed that a new dibenzocyclooctadiene lignan analog XLYF-104-6, with a chemical name of 1,2,3,10,11-pentamethoxydibenzocycloocta-6,7-[c] pyrrole-1,3-dione, inhibited lipopolysaccharide (LPS)-induced NF-kappaB activation in RAW264.7 cells through preventing IkappaBalpha degradation and p65 nuclear translocation. dibenzocyclooctadiene lignan 29-57 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 299-302 24941800-7 2014 RESULTS: After 3 days of LPS intratracheal injection, severe pathological changes, increased W/D, down-regulated AQP-5 expression and increased p-NF-kappaB p65/total NF-kappaB p65 were observed. lps 25-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 156-159 24941800-7 2014 RESULTS: After 3 days of LPS intratracheal injection, severe pathological changes, increased W/D, down-regulated AQP-5 expression and increased p-NF-kappaB p65/total NF-kappaB p65 were observed. lps 25-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 176-179 24941800-8 2014 Compared with mice in the LPS group, mice in the LPS+DG group had more significantly ameliorated pathological changes and increased W/ D, up-regulated AQP-5 expression, and reduced p-NF-kappaB p65/total NF-kappaB p65. lps 49-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 193-196 24941800-8 2014 Compared with mice in the LPS group, mice in the LPS+DG group had more significantly ameliorated pathological changes and increased W/ D, up-regulated AQP-5 expression, and reduced p-NF-kappaB p65/total NF-kappaB p65. lps 49-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 213-216 24462571-2 2014 Herein, we showed that a new dibenzocyclooctadiene lignan analog XLYF-104-6, with a chemical name of 1,2,3,10,11-pentamethoxydibenzocycloocta-6,7-[c] pyrrole-1,3-dione, inhibited lipopolysaccharide (LPS)-induced NF-kappaB activation in RAW264.7 cells through preventing IkappaBalpha degradation and p65 nuclear translocation. xlyf-104-6 65-75 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 299-302 24462571-2 2014 Herein, we showed that a new dibenzocyclooctadiene lignan analog XLYF-104-6, with a chemical name of 1,2,3,10,11-pentamethoxydibenzocycloocta-6,7-[c] pyrrole-1,3-dione, inhibited lipopolysaccharide (LPS)-induced NF-kappaB activation in RAW264.7 cells through preventing IkappaBalpha degradation and p65 nuclear translocation. 1,2,3,10,11-pentamethoxydibenzocycloocta-6,7-[c] pyrrole-1,3-dione 101-167 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 299-302 24530511-9 2014 Copper(II)-initiated microglial activation was accompanied with reduced IkB-alpha expression as well as phosphorylation and translocation of nuclear factor-kappaB (NF-kappaB) p65 and was blocked by NF-kappaB inhibitors (BAY11-7082 and SC-514). cupric ion 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 175-178 24722370-8 2014 Western blotting further indicated that raloxifene suppresses IL-1beta-induced NF-kappaB activation (phosphorylation of p65) and translocation but does not affect phosphorylation of IkappaB. Raloxifene Hydrochloride 40-50 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 120-123 24548765-9 2014 Additionally, western blotting results showed that taraxasterol inhibited the phosphorylation of IkappaB-alpha, p65 NF-kappaB, p46-p54 JNK, p42-p44 ERK, and p38 caused by LPS. taraxasterol 51-63 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 112-125 24552656-9 2014 LPS-increased p65 and C/EBPbeta binding to the COX-2 promoter region was attenuated in the presence of VPA. Valproic Acid 103-106 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 14-17 24632845-12 2014 CONCLUSION: The anti-inflammatory action of daidzein in murine lung epithelial cells seems to be mediated via a direct interaction with PARP-1, which inhibits RelA/p65 protein PARylation required for the transcriptional modulation of pro-inflammatory chemokines such as Cxcl2. daidzein 44-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 164-167 24482236-10 2014 Furthermore, Glrx overexpression removed GSH adducts on p65 in ischemic muscle and EC and enhanced NF-kappaB activity, which was responsible for Wnt5a-sFlt induction. Glutathione 41-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 56-59 24565673-8 2014 LPS-induced nuclear factor kappaB (NF-kappaB) p65 translocation to the nucleus was markedly attenuated by all of the berry anthocyanins. Anthocyanins 123-135 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 46-49 24456746-5 2014 Blockade of CysLT1R by repeated treatment with montelukast (1 or 2 mg/kg, ig, 4 weeks) reduced Abeta1-42-induced CysLT1R expression and also suppressed Abeta1-42-induced increments of NF-kappaB p65, TNF-alpha, IL-1beta and caspase-3 activation, and Bcl-2 downregulation in the hippocampus and cortex. montelukast 47-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 194-197 24638078-10 2014 Additionally, in bone marrow-derived macrophages, metformin treatment partially blunted the effects of lipopolysaccharide on inducing the phosphorylation of JNK1 and nuclear factor kappa B (NF-kappaB) p65 and on increasing the mRNA levels of proinflammatory cytokines. Metformin 50-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 201-204 24658543-5 2014 Furthermore, TiO2 NPs significantly activated the expression of Toll-like receptors (TLR2, TLR4), tumor necrosis factor-alpha, nucleic IkappaB kinase, NF-kappaB-inducible kinase, nucleic factor-kappaB, NF-kappaB2(p52), RelA(p65), and significantly suppressed the expression of IkappaB and interleukin-2. titanium dioxide 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 219-223 24658543-5 2014 Furthermore, TiO2 NPs significantly activated the expression of Toll-like receptors (TLR2, TLR4), tumor necrosis factor-alpha, nucleic IkappaB kinase, NF-kappaB-inducible kinase, nucleic factor-kappaB, NF-kappaB2(p52), RelA(p65), and significantly suppressed the expression of IkappaB and interleukin-2. titanium dioxide 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 224-227 23563178-5 2014 In CS-exposed rela(Delta-/-) mice, the tumor growth was largely inhibited. Cesium 3-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 14-18 24412620-7 2014 Furthermore, we demonstrated that zingerone attenuates the mitogen-activated protein kinases (MAPK) and nuclear factor-kappaB (NF-kappaB) signaling pathways through blocking the phosphorylation of ERK, p38/MAPK and IkappaBalpha, NF-kappaB/P65. zingerone 34-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 239-242 24508132-9 2014 Pre-treatment with MHY884 inhibited Akt and IkappaB kinase alpha/beta signaling pathways, leading to decreased translocation and phosphorylation of p65, a subunit of NF-kappaB. 4-(5-chloro-2,3-dihydrobenzo(d)thiazol-2-yl)-2,6-dimethoxyphenol 19-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 148-151 24637875-10 2014 Specifically, gammaHV68 infection activates IKKbeta and that activated IKKbeta phosphorylates RelA to accelerate RelA degradation. gammahv68 14-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 94-98 24637875-10 2014 Specifically, gammaHV68 infection activates IKKbeta and that activated IKKbeta phosphorylates RelA to accelerate RelA degradation. gammahv68 14-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 113-117 24296134-6 2014 These experiments demonstrated that PL significantly reduced the luciferase activity of an NF-kappaB promoter reporter and p65 nuclear translocation. plumbagin 36-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 123-126 24572641-10 2014 In this study, Western Blot assay showed that HEB could inhibit the activation of NF-kappaB signal pathway stimulated by H2O2 in mouse spleen cells through suppressing NF-kappaB (p65) translocation into nucleus and NF-kappa-B inhibitor (IkappaB) degradation in cytoplasm. Hydrogen Peroxide 121-125 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 179-182 25204186-9 2014 Compared with the cont group, the DSS group showed significantly higher DAI and colonic mucosal lesions, remarkable increase in NF-kappaB p65, IL-8, TNF-alpha expression in colonic tissues, and notable decrease in IL-10 expression (P < 0.05). dss 34-37 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 138-141 25204186-12 2014 Compared with the DSS group, the DSS + FOD-H group and the DSS + FOD-M group showed reduction in colonic mucosal lesions, down-regulation in IL-8, TNF-alpha and NF-kappaB p65 expressions and up-regulation in IL-10 expression (P < 0.05). dss 33-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 171-174 25204186-12 2014 Compared with the DSS group, the DSS + FOD-H group and the DSS + FOD-M group showed reduction in colonic mucosal lesions, down-regulation in IL-8, TNF-alpha and NF-kappaB p65 expressions and up-regulation in IL-10 expression (P < 0.05). dss 33-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 171-174 24624340-9 2014 Immunohistochemical analysis of Nrf2, HO-1 and p65 was conducted and confirmed that treatment with desoxyrhapontigenin induced Nrf2 and HO-1 expression but reduced p65 expression. 3,5-dihydroxy-4'-methoxystilbene 99-118 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 47-50 24624340-9 2014 Immunohistochemical analysis of Nrf2, HO-1 and p65 was conducted and confirmed that treatment with desoxyrhapontigenin induced Nrf2 and HO-1 expression but reduced p65 expression. 3,5-dihydroxy-4'-methoxystilbene 99-118 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 164-167 24232001-7 2014 In accordance with the in vivo results, paeoniflorin downregulated TLR4 expression, blocked nuclear translocation of NF-kappaB p65, and reduced the production of IL-6 in LPS-stimulated mouse macrophage RAW264.7 cells. peoniflorin 40-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 127-130 24161915-9 2014 Additionally, western blotting showed that CTN efficiently inhibited the phosphorylation of IkappaB-alpha, p65 NF-kappaB and the expression of TLR4. Cytidine 43-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-120 24407238-7 2014 5"-AMP failed to attenuate LPS-induced nuclear factor-kappaB (NF-kappaB) p65 nuclear translocation, but reduced LPS-induced recruitment of NF-kappaB p65 to inflammatory gene promoters and decreased LPS-induced enrichment of H3K4 dimethylation at the tumor necrosis factor-alpha (TNF-alpha) promoter, which was involved in 5"-AMP-induced elevation of cellular adenosine and a decline of methylation potential. Adenosine Monophosphate 0-6 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 149-152 24258363-3 2014 Pretreatment with MSE in mouse skin has led to the reduction of TPA-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunits as well as phosphorylation of IkappaBalpha and p65 subsequent reduction of IkappaBalpha degradation. Tetradecanoylphorbol Acetate 64-67 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 194-197 24231956-7 2014 Simultaneously, DETT increased IkappaBalpha, an inhibitor of the p65/p50 heterodimer, even in the presence of stimulants lipopolysaccharide, tumour necrosis factor-alpha, or interleukin-6. dett 16-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 65-68 24989009-5 2014 Tomentosin not only attenuated lipopolysaccharide (LPS)-induced NF-kappaB activation via the abrogation of inhibitory (I)kappaBalpha degradation and caused a subsequent decrease in nuclear p65 level, but it also suppressed the phosphorylation of MAP kinases (p38 and c-Jun N terminal kinase (JNK)). tomentosin 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 189-192 24628271-7 2014 In both in vitro and in vivo studies, we found that UBS109 decreased the levels of phosphorylated IKKbeta and phosphorylated p65 and, unexpectedly, increased the levels of phosphorylated IkappaBalpha by Western blot analysis. UBS109 52-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 125-128 25366476-8 2014 17-DMAG suppressed activation of microglia and decreased phosphorylation of inhibitory (I)kappaB and subsequent nuclear translocation of p65, which eventually downregulated expression of NF-kappaB-regulated genes. 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 137-140 25482945-5 2014 Treatment with DHA increases IkappaB-alpha protein and blocks nuclear translocation of NF-kappaB p65. artenimol 15-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 97-100 25482945-6 2014 In addition, DHA directly regulates VEGFR2 promoter activity through p65 binding motif, and decreases the binding activity of p65 and VEGFR2 promoter, suggesting defective NF-kappaB signaling may underlie the observed effects of DHA on VEGFR2 expression. artenimol 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-72 25482945-6 2014 In addition, DHA directly regulates VEGFR2 promoter activity through p65 binding motif, and decreases the binding activity of p65 and VEGFR2 promoter, suggesting defective NF-kappaB signaling may underlie the observed effects of DHA on VEGFR2 expression. artenimol 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 126-129 25482945-6 2014 In addition, DHA directly regulates VEGFR2 promoter activity through p65 binding motif, and decreases the binding activity of p65 and VEGFR2 promoter, suggesting defective NF-kappaB signaling may underlie the observed effects of DHA on VEGFR2 expression. artenimol 229-232 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 126-129 24369292-2 2014 The inhibitory effect seems to be the result of the ring opening of an epoxide of 1 with Cys(38) of p65. Epoxy Compounds 71-78 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 100-103 24369292-2 2014 The inhibitory effect seems to be the result of the ring opening of an epoxide of 1 with Cys(38) of p65. Cysteine 89-92 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 100-103 24274545-5 2014 LPS enhanced O-GlcNAc modification of NF-kappaB/p65 and activated NF-kappaB pathway, which could be prevented either by siRNA knockdown of O-GlcNAc transferase (OGT) or pretreatment with COS. o-glcnac 13-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 48-51 24274545-5 2014 LPS enhanced O-GlcNAc modification of NF-kappaB/p65 and activated NF-kappaB pathway, which could be prevented either by siRNA knockdown of O-GlcNAc transferase (OGT) or pretreatment with COS. carbonyl sulfide 187-190 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 48-51 24628271-8 2014 These observations may suggest that UBS109 suppresses tumor growth through, in part, inhibition of NF-kappaB p65 phosphorylation by PKAc and not through IkappaBalpha. UBS109 36-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-112 24723958-6 2014 In addition, EORP reduced the phosphorylation and nuclear translocation of nuclear factor- (NF-) kappa B p65 in LPS-treated HASMCs. hasmcs 124-130 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 105-108 24744815-8 2014 These EAFA-induced events were apparently associated with NF- kappa B and MAPK signaling pathways because the DNA binding activity of p50/p65 was impaired and the activities of both ERK and JNK were decreased in EFEA-treated cells comparing to untreated cells. eafa 6-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 138-141 24091016-6 2013 Moreover, SC-514 specifically suppressed NF-kappaB activity owing to delayed RANKL-induced degradation of IkappaBalpha and inhibition of p65 nuclear translocation. SC 514 10-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 137-140 25242406-9 2014 Dexmedetomidine restrained the phosphorylation of NF-kappaB IkappaBalpha and P-65 dramatically which may participate in the regulation of cytokines secretion. Dexmedetomidine 0-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 50-81 25147439-6 2014 Treatment with palmitoleate markedly attenuated the insulin resistance induced by the HFD, increased glucose uptake and incorporation into muscle in vitro, reduced the serum levels of AST in WT mice, decreased the hepatic levels of IL1-beta and IL-12 in KO mice, reduced the expression of TLR-4 and increased the expression of IL-1Ra in WT mice, and reduced the phosphorylation of NF B (p65) in the livers of KO mice. palmitoleic acid 15-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 391-394 24056124-7 2013 Tunicamycin inhibited nuclear factor-kappaB (NF-kappaB) activity by suppressing LPS-induced nuclear translocation of p50 and subsequent DNA binding of p50 and p65 to the NF-kappaB site of the iNOS promoter. Tunicamycin 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 159-162 24145059-7 2013 We observed that SA increased the levels of the phosphorylated forms of nuclear factor of kappa light polypeptide gene enhancer in B cells (NF-kappaB)/p65. sodium arsenite 17-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 151-154 24005906-7 2013 Moreover, Toll-like receptor 4 signaling via Akt/JNK phosphorylation and p65 nuclear translocation was repressed by DHA-activated FFA4 coupling with beta-arrestin 2, which was reversed by FFA4 knockdown. Docosahexaenoic Acids 116-119 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-76 24105415-4 2013 Transgenic (Tg) mice overexpressing p65 in macrophages were generated by crossing fatty acid-binding protein 4 (aP2) promoter-controlled p65 mice with apoE-knockout (KO) mice. Fatty Acids 82-92 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 36-39 24135201-10 2013 Moreover, KR-67105 attenuated cortisone induced iNOS expression and phosphorylation of NF-kappaB p65, p38 MAPK, and ERK1/2 in preadipocytes. Cortisone 30-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 97-100 23891677-0 2013 Up-down regulation of HO-1 and iNOS gene expressions by ethyl pyruvate via recruiting p300 to Nrf2 and depriving It from p65. ethyl pyruvate 56-70 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-124 24036212-10 2013 The activation of p38MAPK and Erk1/2, and the nuclear translocation of NFkappaB(p65) were increased evidently in TGFbeta1-treated cell, which could be dramatically prohibited by the application of the p38MAPK inhibitor SB202190 and the Ras inhibitor FPT Inhibitor III. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 219-227 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 80-83 24204775-10 2013 Furthermore, tunicamycin-induced ROS production activated nuclear translocation of NFkappaB p65 and was required for ER stress-mediated expression of PTP1B. Tunicamycin 13-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 92-95 24044884-7 2013 Helenalin attenuated ligand-independent activation of NF-kappaB induced by MyD88, IKKbeta, and p65, and IRF3 induced by TRIF, TBK1, or IRF3. helenalin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-98 24188583-10 2013 BBR, TAK-242 or SP-600125 (1 muM) could significantly reduce the levels of MCP-1, IL-6 and TNF-alpha, insulin and JNK and NF-kappaB phosphorylation in NIT-1 cells, as well as the p65 NF-kappaB in INS-1 cells. Berberine 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 179-192 24188583-10 2013 BBR, TAK-242 or SP-600125 (1 muM) could significantly reduce the levels of MCP-1, IL-6 and TNF-alpha, insulin and JNK and NF-kappaB phosphorylation in NIT-1 cells, as well as the p65 NF-kappaB in INS-1 cells. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 5-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 179-192 24188583-10 2013 BBR, TAK-242 or SP-600125 (1 muM) could significantly reduce the levels of MCP-1, IL-6 and TNF-alpha, insulin and JNK and NF-kappaB phosphorylation in NIT-1 cells, as well as the p65 NF-kappaB in INS-1 cells. pyrazolanthrone 16-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 179-192 24204674-11 2013 In addition, metformin nearly abrogated the binding of NF-kappaB subunit p65 to the iNOS promoter gene in lung tissue of obese mice. Metformin 13-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-76 24204775-10 2013 Furthermore, tunicamycin-induced ROS production activated nuclear translocation of NFkappaB p65 and was required for ER stress-mediated expression of PTP1B. Reactive Oxygen Species 33-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 92-95 24155943-13 2013 An in vitro study demonstrated COS increased IkappaB expression, attenuated the increase of p65 and thus decreased NF-kappaB/DNA binding activity in PQ-stimulated RGC-5 cells. carbonyl sulfide 31-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 92-95 23994062-4 2013 TG treatment increased the levels of phospho-NF-kappaB p65 in hypothalamic cultures, and inhibitors of NF-kappaB p65 reversed the inhibitory effects of TG on NPY and AgRP expression. Thapsigargin 0-2 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 23583295-9 2013 The significantly increased binding of p65 and c-Jun to the CCL2 promoter was also observed in the lung tissue of bleomycin-induced pulmonary fibrosis murine model. Bleomycin 114-123 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 39-42 23913709-0 2013 Cardiomyocyte-specific p65 NF-kappaB deletion protects the injured heart by preservation of calcium handling. Calcium 92-99 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 23-26 23913709-10 2013 Furthermore, p65 ablation was associated with enhanced calcium reuptake by the sarcoplasmic reticulum. Calcium 55-62 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 13-16 23913709-11 2013 This influence on calcium handling was related to increased expression of phosphorylated phospholamban in conditional p65 null mice. Calcium 18-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-121 23605560-10 2013 Ber pretreatment also profoundly diminished CS-induced secretions of macrophage inflammatory protein 2, tumor necrosis factor alpha, interleukin-6, and monocyte chemotactic protein-1 in BALF, along with less nuclear translocation of the pro-inflammatory transcription factor nuclear factor-kappa B (NF-kappaB) p65 subunit and lower NF-kappaB DNA-binding activity (P < 0.01). Cesium 44-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 310-313 23590664-0 2013 NF-kappaB p65/p52 plays a role in GDNF up-regulating Bcl-2 and Bcl-w expression in 6-OHDA-induced apoptosis of MN9D cell. Oxidopamine 83-89 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 10-13 23912183-10 2013 TMP upregulated the protein expression of cytosolic NF-kappaB p65, while downregulating the protein expression of nuclear NF-kappaB p65, BCL-2 and cyclin D1. tetramethylpyrazine 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 62-65 23912183-10 2013 TMP upregulated the protein expression of cytosolic NF-kappaB p65, while downregulating the protein expression of nuclear NF-kappaB p65, BCL-2 and cyclin D1. tetramethylpyrazine 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 132-135 23322372-8 2013 Doxorubicin treatment raised cardiac activity and protein production of caspase-3, nuclear factor kappa B (NF-kappaB) p50 and p65. Doxorubicin 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 126-129 23951048-14 2013 NF-kappaB activation measured by phosphorylation of p65 and neuroinflammation were reduced in alcohol-fed TLR4-KO compared to control mice. Alcohols 94-101 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 52-55 23506745-7 2013 Consistent with the in vivo results, naringenin exposure blocked lipopolysaccharide-stimulated nuclear translocation of NF-kappaB p65 in mouse macrophage RAW264.7 cells. naringenin 37-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 130-133 23680674-6 2013 ATPgammaS-induced p38 MAPK, p42/p44 MAPK, and NF-kappaB p65 activation were inhibited by Go6976, Ro-318220, GF109203X, or rottlerin. adenosine 5'-O-(3-thiotriphosphate) 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 56-59 23680674-6 2013 ATPgammaS-induced p38 MAPK, p42/p44 MAPK, and NF-kappaB p65 activation were inhibited by Go6976, Ro-318220, GF109203X, or rottlerin. Go 6976 89-95 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 56-59 23680674-6 2013 ATPgammaS-induced p38 MAPK, p42/p44 MAPK, and NF-kappaB p65 activation were inhibited by Go6976, Ro-318220, GF109203X, or rottlerin. Ro 31-8220 97-106 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 56-59 23987495-9 2013 Western blotting showed that celecoxib and combined treatment significantly inhibited the protein expression of COX-2 and NF-KappaB p65(P<0.05), but not capecitabine. Celecoxib 29-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 132-135 23987495-10 2013 CONCLUSION: Celecoxib can enhance the antitumor effect of capecitabine by inhibiting the expressions of COX-2 and NF-KappaB p65 in mice bearing H22 implanted tumor. Celecoxib 12-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 124-127 23987495-10 2013 CONCLUSION: Celecoxib can enhance the antitumor effect of capecitabine by inhibiting the expressions of COX-2 and NF-KappaB p65 in mice bearing H22 implanted tumor. Capecitabine 58-70 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 124-127 24131734-10 2013 Additionally, analysis of inflammatory signaling pathways showed suppressed activation of NF-kappaB and marginally reduced activation of JNK in acrolein-exposed lungs, associated with increased carbonylation of RelA and JNK. Acrolein 144-152 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 211-215 23869429-7 2013 Our results also show that visfatin-induced iNOS expression and NO production were significantly inhibited by melatonin, an effect that was closely associated with a reduction in phosphorylated JAK2/STAT3 levels and with the inhibition of p65 translocation into nucleus. Melatonin 110-119 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 239-242 24086374-6 2013 In addition, BA suppressed IkappaB phosphorylation, p65 phosphorylation and nuclear translocation, and the transcription of NF-kappaB-dependent related gene. betulinic acid 13-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 52-55 23926321-4 2013 We also found that DeltarodA and hydrofluoric acid-treated conidia stimulate significantly higher NF-kappaB p65 nuclear translocation and cytokine production by macrophages from C57BL/6, but not from Dectin-1(-/-) or Dectin-2(-/-) mice. deltaroda 19-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 108-111 23926321-4 2013 We also found that DeltarodA and hydrofluoric acid-treated conidia stimulate significantly higher NF-kappaB p65 nuclear translocation and cytokine production by macrophages from C57BL/6, but not from Dectin-1(-/-) or Dectin-2(-/-) mice. Hydrofluoric Acid 33-50 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 108-111 23399806-9 2013 Further, TPA induced altered expression of NF-kappaB (p65) and COX-2 was also attenuated by GOH. Tetradecanoylphorbol Acetate 9-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 54-57 23557759-9 2013 In addition, DPN inhibited nuclear translocation and phosphorylation of p65 by inhibiting IkappaB degradation and thus prohibited the activation of nuclear factor kappaB (NF-kappaB). diarylpropionitrile 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 23317035-10 2013 PGE2, dbcAMP and 8-Cpt-cAMP induced the phosphorylation of Akt, IkappaB kinase and IkappaBalpha and the translocation of p65 to the nucleus and increased NF-kappaB dependent reporter gene activity, which was diminished by Akti. Dinoprostone 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-124 23317035-10 2013 PGE2, dbcAMP and 8-Cpt-cAMP induced the phosphorylation of Akt, IkappaB kinase and IkappaBalpha and the translocation of p65 to the nucleus and increased NF-kappaB dependent reporter gene activity, which was diminished by Akti. Bucladesine 6-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-124 23317035-10 2013 PGE2, dbcAMP and 8-Cpt-cAMP induced the phosphorylation of Akt, IkappaB kinase and IkappaBalpha and the translocation of p65 to the nucleus and increased NF-kappaB dependent reporter gene activity, which was diminished by Akti. 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP 17-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-124 23142797-14 2013 Significant increase in the protein levels of p53, c-jun, and p65 were observed in DMBA-treated mice, whereas less expression was observed in AQCE-treated animals. 9,10-Dimethyl-1,2-benzanthracene 83-87 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 62-65 23729445-6 2013 The specific knockdown of mitogen- and stress-activated protein kinase 1 in macrophages resulted in a defective phosphorylation of NF-kappaB/RelA at Ser(276) but had no apparent effect on RelA translocation. Serine 149-152 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 141-145 23349493-6 2013 In vitro stimulation of LGALS3(-/-) peritoneal macrophages with lipopolysaccharide (LPS) and saturated fatty acid palmitate caused increased caspase-1-dependent IL-1beta production and increased phosphorylation of NF-kappaB p65 compared with WT cells. saturated fatty acid palmitate 93-123 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 224-227 23429041-6 2013 DHA also remarkably reduced PMA-induced p65, C/EBPbeta, c-jun and CREB nuclear translocation. artenimol 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-43 23429041-6 2013 DHA also remarkably reduced PMA-induced p65, C/EBPbeta, c-jun and CREB nuclear translocation. Tetradecanoylphorbol Acetate 28-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-43 23734085-8 2013 Furthermore, less proinflammatory factors, including nuclear factor-kappa (p65), cyclooxygenase-2, Fas L, and Fas, were induced in the corneas protected by Etafilcon A and HEMA+MA. etafilcon 156-167 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 75-78 23769029-7 2013 Compared with nontreated animals, everolimus-treated animals showed significantly increased TNF-alpha (2741.6 +- 201.72 pg/mg; 1925 +- 185.81 pg/mg, P < .05) and IL-1beta (11.47 +- 1.2 pg/mg; 4.3 +- 0.13 pg/mg, P < .01) production on day 2 after IRI induction accompanied by significantly greater NF-kappaB/DNA binding activity and p65 nuclear expression (P < .01). Everolimus 34-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 338-341 23353591-6 2013 Furthermore, a phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 significantly suppressed LPS-induced NF-kappaB p65 nuclear translocation, iNOS expression, and NO production, which was also mimicked by pretreatment with DSC. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 62-70 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-121 23500883-10 2013 Moreover, treatment with alpha-cyperone suppressed the transcriptional activity of NFkappaB and the nuclear translocation of the p65 NFkappaB subunit in LPS-induced RAW 264.7 cells. alpha-cyperone 25-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 129-141 23338948-4 2013 Furthermore, CeCl3 remarkably increased levels of Toll-like receptors 2 and 4, tumor necrosis factor-alpha, nucleic IkappaB kinase, factor-kappaB-inducible kinase, nucleic factor-kappaB, and p52 and p65 expression as well as significantly decreased levels of IkappaB and interleukin-2 expression. cerous chloride 13-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 199-202 23566812-3 2013 Furthermore, TMC suppressed tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production, and the phosphorylation and degradation of IkappaB-alpha as well as the LPS-stimulated nuclear translocation of p65 in macrophages. 4,2',5'-trihydroxy-4'-methoxychalcone 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 225-228 23438680-5 2013 Western blot analysis indicated that U0126 also inhibited the phosphorylation of p65 subunit of NF-kappaB (p65), indicating that MIP-2 was produced via the ERK/NF-kappaB pathway. U 0126 37-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 81-84 23438680-5 2013 Western blot analysis indicated that U0126 also inhibited the phosphorylation of p65 subunit of NF-kappaB (p65), indicating that MIP-2 was produced via the ERK/NF-kappaB pathway. U 0126 37-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-110 23435932-8 2013 Additionally, gossypol reduced the inflammatory cells in BALF, decreased the wet/dry ratio of lungs and inhibited the phosphorylation of IkappaB-alpha, p65 NF-kappaB, p46-p54 JNK, p42-p44 ERK, and p38 caused by LPS. Gossypol 14-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 152-165 23348408-6 2013 PA inhibited IkappaB-alpha degradation and p65 nuclear translocation, and subsequently suppressed transcriptional activity of NF-kappaB in LPS-stimulated RAW264.7 and TNF-alpha-stimulated HT-29 cells. patchouli alcohol 0-2 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 43-46 23562811-6 2013 DSS-induced CCL11 expression, eosinophilic inflammation, and histopathology were attenuated in RelA/p65(Deltamye) mice, but not in the absence of STAT-6. dss 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-99 23562811-6 2013 DSS-induced CCL11 expression, eosinophilic inflammation, and histopathology were attenuated in RelA/p65(Deltamye) mice, but not in the absence of STAT-6. dss 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 100-103 23661516-9 2013 The ratio of phospho-NF-kappaB p65 to total NF-kappaB p65 was much lower in mice treated with hydrogen-rich saline than in untreated mice. Hydrogen 94-102 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-34 23143538-13 2013 Results show that kinsenoside does not inhibit IKK phosphorylation but suppresses the phosphorylation of IkappaBalpha and p65. 3-glucopyranosyloxybutanolide 18-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-125 23524568-7 2013 RESULTS: The STZ-induced diabetic mice characterized by hyperglycemia and hypoinsulinemia performed poorly in both the passive avoidance and MWM tests, accompanied by increased Abeta1-40/Abeta1-42, APP, BACE1, NF-kappaB p65 and RAGE levels and decreased PPARgamma level in the hippocampus and cortex. Streptozocin 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 220-223 23524568-8 2013 Chronic pioglitazone treatment significantly ameliorated the memory deficits and amyloidogenesis of STZ-induced diabetic mice, and suppressed expression of APP, BACE1, RAGE and NF-kappaB p65, and activated PPARgamma in the hippocampus and cortex. Pioglitazone 8-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 187-190 23021350-9 2013 In addition, the phosphorylated forms of Akt, a downstream kinase of PI3K, and NF-kappaB p65 increased after ZnCl2 exposure. zinc chloride 109-114 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 89-92 23302291-8 2013 delta-Tocotrienol treatment inhibited mutant Kras-driven pathways such as MEK/ERK, PI3K/AKT and NF-kB/p65, as well as Bcl-xL and induced p27. tocotrienol, delta 0-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-105 23180366-6 2013 Furthermore, we demonstrated that limonene blocked the phosphorylation of IkappaBalpha, nuclear factor-kappaB (NF-kappaB) p65, p38 mitogen-activated protein kinase (MAPK), c-Jun NH2-terminal kinase, and extracellular signal-regulated kinase in LPS-induced ALI. Limonene 34-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-125 23499680-6 2013 Pretreatment with ETH reduced the I-kappaBalpha phosphorylation, p65 nuclear translocation as well as NF-kappaB-dependent transcriptional activity. 1-(4-ethoxyphenyl)-3-(4-nitrophenyl)-prop-2-en-1-one 18-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 65-68 23661516-9 2013 The ratio of phospho-NF-kappaB p65 to total NF-kappaB p65 was much lower in mice treated with hydrogen-rich saline than in untreated mice. Hydrogen 94-102 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 54-57 23318472-6 2013 In cultured renal tubular HK-2 cells, paclitaxel decreased the DNA-binding activity of nuclear factor-kappaB (NF-kappaB) during LPS treatment, inhibited the degradation of the inhibitor of kappaB-alpha, and blocked the expression and activation of NF-kappaB p65. Paclitaxel 38-48 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 258-261 23274771-2 2013 Therefore, we tried to assess the involvement of the p65 subunit of NF-kappaB in the embryonic response to the anti-cancer drug Doxorubicin (DOX). Doxorubicin 128-139 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 23268108-6 2013 In addition, beta-ionone significantly reduced DNA-binding activity of nuclear factor-kappaB (NF-kappaB) through suppression of nuclear translocation of p50 and p65. beta-ionone 13-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 161-164 22982818-9 2013 Pancreatic NF-kappaB p65 expression decreased significantly after inflexinol treatment (P < 0.05). ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate 66-76 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 21-24 23274771-2 2013 Therefore, we tried to assess the involvement of the p65 subunit of NF-kappaB in the embryonic response to the anti-cancer drug Doxorubicin (DOX). Doxorubicin 141-144 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 23274771-3 2013 Thus, exposure of p65 knockout (p65(-/-)) or wild type (WT) mouse embryonic fibroblasts (MEFs) to DOX resulted in a decrease in cell survival, culture density and cell proliferation, which was found to be more prominent in p65(-/-) MEFs. Doxorubicin 98-101 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 18-21 23274771-3 2013 Thus, exposure of p65 knockout (p65(-/-)) or wild type (WT) mouse embryonic fibroblasts (MEFs) to DOX resulted in a decrease in cell survival, culture density and cell proliferation, which was found to be more prominent in p65(-/-) MEFs. Doxorubicin 98-101 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 32-35 23274771-3 2013 Thus, exposure of p65 knockout (p65(-/-)) or wild type (WT) mouse embryonic fibroblasts (MEFs) to DOX resulted in a decrease in cell survival, culture density and cell proliferation, which was found to be more prominent in p65(-/-) MEFs. Doxorubicin 98-101 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 32-35 23274771-4 2013 Those phenomena were accompanied by a DOX-induced increase in the proportion of apoptotic cells, which was demonstrated only in p65(-/-) cells and a G2/M arrest, which was found to be more prominent in WT cells. Doxorubicin 38-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-131 23274771-5 2013 Furthermore, DOX-treated WT and p65(-/-) MEFs differed in their expression of various apoptosis-associated molecules, when the former demonstrated a decrease in the percentage of p65-positive and a more prominent decrease in the percentage of p53-positive cells, while a decreased percentage of IkappaBalpha-positive and a more prominent decrease in the percentage of bcl-2-positive cells was detected among the latter. Doxorubicin 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 32-35 23274771-5 2013 Furthermore, DOX-treated WT and p65(-/-) MEFs differed in their expression of various apoptosis-associated molecules, when the former demonstrated a decrease in the percentage of p65-positive and a more prominent decrease in the percentage of p53-positive cells, while a decreased percentage of IkappaBalpha-positive and a more prominent decrease in the percentage of bcl-2-positive cells was detected among the latter. Doxorubicin 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 179-182 23510834-8 2013 Compared with the paraquat poisoning group, the thalidomide treatment groups had significantly decreased levels of TNF-alpha, IL-1beta, IL-6, NF-kappaB mRNA, and nuclear NF-kappaB p65 and wet/dry ratios of the lung (P < 0.05), and the 150 mg/kg thalidomide treatment group showed the most significant decrease in the levels of TNF-alpha, IL-1beta, IL-6, NF-kappaB mRNA, and nuclear NF-kappaB p65. Thalidomide 48-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 180-183 23510834-7 2013 RESULTS: Compared with the negative control group, the paraquat poisoning group had significantly increased levels of TNF-alpha, IL-1beta, IL-6, NF-kappaB mRNA, and nuclear NF-kappaB p65 and wet/dry ratio of the lung (P < 0.05). Paraquat 55-63 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 183-186 23274771-6 2013 The fact that the response of the cells to the teratogen was clearly p65-dependent implicates this molecule to be involved in the response of the embryonic cells to DOX. Doxorubicin 165-168 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-72 23510834-8 2013 Compared with the paraquat poisoning group, the thalidomide treatment groups had significantly decreased levels of TNF-alpha, IL-1beta, IL-6, NF-kappaB mRNA, and nuclear NF-kappaB p65 and wet/dry ratios of the lung (P < 0.05), and the 150 mg/kg thalidomide treatment group showed the most significant decrease in the levels of TNF-alpha, IL-1beta, IL-6, NF-kappaB mRNA, and nuclear NF-kappaB p65. Thalidomide 48-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 395-398 23246654-11 2013 While ApoE did not affect the activation of ERK, JNK, and p38 MAPK signaling pathways by RANKL, the phosphorylation of p65 trans-activation domain on serine 536 and transcription activity of NF-kappaB were reduced by ApoE overexpression. Serine 150-156 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-122 23262090-3 2013 Honokiol (0.1-10muM) significantly reduced the p65 subunit level of NF-kappaB in the nucleus of primary culture-microglia. honokiol 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 47-50 23246979-2 2013 In the present study, we found that diosgenin significantly suppressed the phosphorylation of lung NF-kappaB p50/p65 and MAPK/p38 in lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice, when given orally at doses of 0.1, 1.0 and 10mg/kg 1h prior to LPS challenge (30 mg/kg, intravenous injection). Diosgenin 36-45 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 113-116 23352443-5 2013 Furthermore, gossypol blocked the phosphorylation of IkappaBalpha protein, p65, p38, c-Junterminal kinase (JNK) and extracellular signal-regulated kinase (ERK) in LPS stimulated RAW 264.7 cells. Gossypol 13-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 75-78 23218803-7 2013 And the data showed that glibenclamide could ameliorate the progress of atherosclerosis and reduce the production of inflammatory cytokines as well as the phosphorylation of p65 and ERK1/2, while inhibitors of p65 leaded to robust expression of K(ATP) subunits in macrophages. Glyburide 25-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 174-177 23218803-7 2013 And the data showed that glibenclamide could ameliorate the progress of atherosclerosis and reduce the production of inflammatory cytokines as well as the phosphorylation of p65 and ERK1/2, while inhibitors of p65 leaded to robust expression of K(ATP) subunits in macrophages. Glyburide 25-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 210-213 23174480-10 2013 Moreover, PBA inhibited CCl(4)-induced hepatic nuclear factor kappa B (NF-kappaB) p65 translocation and extracellular signal-regulated kinase (ERK) and c-Jun N-terminal Kinase (JNK) phosphorylation. Cefaclor 24-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 23125156-9 2013 In addition, the ethanol-induced upregulation of chemokine KC, a mouse homolog of IL-8, and phosphorylated p65 NF-kappaB signals were significantly inhibited in murine gastric mucosa pretreated with GG-52. Ethanol 17-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-120 23084372-4 2013 Furthermore, Adjudin exhibited anti-inflammatory properties by suppression of NF-kappaB p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation. 1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide 13-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 23303310-5 2013 Enhancing RANK signalling in cultured neurons resulted in NF-kappaB activation and phosphorylation of the p65 NF-kappaB subunit on serine 536. Serine 131-137 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 106-109 23041330-1 2013 BACKGROUND & AIMS: The transcription factor nuclear factor-kappaB (NF-kappaB) (a heterodimer of NF-kappaB1p50 and RelA) is activated rapidly in acute pancreatitis (AP). Adenosine Monophosphate 12-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-122 23483870-5 2013 Ginsenoside Rh2 was further shown to inhibit NF- kappa B p65 translocation into the nucleus by suppressing I kappa B- alpha degradation. ginsenoside Rh2 0-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 57-60 23059190-5 2013 COS-S also significantly suppressed NO production, the activity and mRNA expression of iNOS, and the protein level of NF-kappaB protein p65, which were activated by H(2)O(2). oligochitosan 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-139 23766559-6 2013 IL-10-deficient mice exposed to carrageenan in a germ-free environment showed an increase in activation of the canonical pathway of NF-kappaB (RelA) activation, but without increase in RelB or phospho-Bcl10, and exogenous IL-10 inhibited only the canonical pathway of NF- kappa B activation in cultured colonic cells. Carrageenan 32-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 143-147 24369446-7 2013 Furthermore, ZY-induced nuclear translocation and DNA-binding activity of NF- kappa B p65 were also reduced by ISO. Zymosan 13-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 86-89 22915087-6 2013 Further studies revealed that salidroside down-regulated phosphorylation of LPS-induced nuclear transcription factor-kappaB (NF-kappaB) p65 and inhibitor of NF-kappaB alpha (IkappaBalpha) in the NF-kappaB signal pathway, and suppressed phosphorylation of p38, extracellular signal-regulated kinase (ERK) and c-jun NH(2)-terminal kinase (JNK) in MAPKs signal pathways. rhodioloside 30-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-139 24250585-6 2013 It was shown that oxymatrine inhibited the productions of NO, PGE2, TNF-alpha, IL-1beta and IL-6, attenuated the mRNA levels of iNOS and COX-2, suppressed the phosphorylation of I-kappaBalpha in cytosol, decreased the nuclear levels of p65, and also blocked ERK, p38 and JNK pathway in LPS-stimulated BV2 microglial cells in a dose-dependent manner. oxymatrine 18-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 236-239 23710113-4 2013 ISO also inhibited ZY-induced expression and activation of nuclear factor-kappaB p65 and inducible nitric oxide synthase in pulmonary tissue. Isoflurane 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 81-84 23710113-4 2013 ISO also inhibited ZY-induced expression and activation of nuclear factor-kappaB p65 and inducible nitric oxide synthase in pulmonary tissue. Zymosan 19-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 81-84 23737649-8 2013 In addition, genistein treatment decreased inflammatory markers such as nuclear factor kappa B (p65), phosphorylated inhibitory kappa B alpha, C-reactive protein, monocyte chemotactic protein-1, cyclooxygenase-2, and tumor necrosis factor-alpha and improved oxidative stress markers (nuclear-related factor E2, heme oxygenase-1, glutathione peroxidase, and superoxide dismutase isoforms) in treatment groups, regardless of the genistein treatment dose. Genistein 13-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 96-99 23383175-6 2013 Anatabine appears to significantly suppress STAT3 and p65 NFkappaB phosphorylation in the spleen and the brain of EAE mice. anatabine 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 54-57 22971966-2 2013 In harmful ischemia, but not in preconditioning insult, neurotoxic activation of p50/RelA is characterized by RelA-specific acetylation at Lys310 (K310) and deacetylation at other Lys residues. L-arabinitol 147-151 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 85-89 22971966-2 2013 In harmful ischemia, but not in preconditioning insult, neurotoxic activation of p50/RelA is characterized by RelA-specific acetylation at Lys310 (K310) and deacetylation at other Lys residues. Lysine 139-142 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 85-89 22971966-2 2013 In harmful ischemia, but not in preconditioning insult, neurotoxic activation of p50/RelA is characterized by RelA-specific acetylation at Lys310 (K310) and deacetylation at other Lys residues. Lysine 139-142 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 110-114 22971966-7 2013 RESULTS: The combined use of MS-275 and resveratrol, by restoring normal RelA acetylation, elicited a synergistic neuroprotection in neurons exposed to OGD. entinostat 29-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-77 22971966-7 2013 RESULTS: The combined use of MS-275 and resveratrol, by restoring normal RelA acetylation, elicited a synergistic neuroprotection in neurons exposed to OGD. Resveratrol 40-51 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-77 22971966-8 2013 This effect correlated with MS-275 capability to increase total RelA acetylation and resveratrol capability to reduce RelA K310 acetylation through the activation of an AMP-activated protein kinase-sirtuin 1 pathway. entinostat 28-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-68 22971966-8 2013 This effect correlated with MS-275 capability to increase total RelA acetylation and resveratrol capability to reduce RelA K310 acetylation through the activation of an AMP-activated protein kinase-sirtuin 1 pathway. Resveratrol 85-96 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-122 25198663-9 2013 (-)-DHMEQ prevented this increase in p65 activity and the subsequent expressions of antiapoptotic molecules. dehydroxymethylepoxyquinomicin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 37-40 23437361-7 2013 The expression of IL-6, IL-10, IFNgamma, and MCP-1, key chemokines/cytokines implicated in the development of ALI/ARDS, from both the inflammatory infiltrate and whole lung tissue were modulated by curcumin potentially through a reduction in the phosphorylated form of NFkappaB p65. Curcumin 198-206 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 278-281 22961094-6 2013 The results show that Cd stimulated nuclear translocation of Trx1 and p65 of NF-kappaB. Cadmium 22-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 22878137-7 2012 Geniposide blocked the phosphorylation of IkappaBalpha, p65, p38, ERK and JNK in LPS stimulated primary mouse macrophages. geniposide 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 56-59 23258328-10 2012 Acetylation of NF-kappaB/p65(Lys310), which was already increased by LPS, was further enhanced by TSA (P < 0.05). trichostatin A 98-101 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 25-28 23258328-11 2012 On the contrary, LPS-increased DNA binding activity of NF-kappaB/p65 was decreased by pretreatment with TSA (P < 0.05). trichostatin A 104-107 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 65-68 23258328-12 2012 The results suggest that TSA-induced anti-inflammation may be attributed to decreases in the expression of TLR4 and DNA binding activity of NF-kappaB/p65. trichostatin A 25-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 150-153 23199346-12 2012 The PPARgamma inhibitor GW9662 partially reversed RvD1-induced suppression of IkappaBalpha degradation and p65 nuclear translocation. 2-chloro-5-nitrobenzanilide 24-30 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-110 22974838-4 2012 In addition, caffeine significantly decreased LPS-induced DNA-binding activity of nuclear factor-kappaB (NF-kappaB) by suppressing the nuclear translocation of p50 and p65 subunits. Caffeine 13-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 168-171 22940184-4 2012 Investigation of the effects on nuclear factor kappaB (NF-kappaB) signaling showed that alantolactone inhibits the phosphorylation of inhibitory kappaB (IkappaB)-alpha and IkappaB kinase (IKK) and the subsequent translocation of the p65 and p50 NF-kappaB subunits to the nucleus. alantolactone 88-101 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 233-236 22782996-7 2012 Furthermore, NFkappaB (p65) was also highly activated at the same time point (as measured by phosphorylation at ser276) in epidermis of DBA/2 mice compared with C57BL/6 mice. 1,2,5,6-dibenzanthracene 136-139 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 23-26 23232512-10 2012 Fasudil inhibited the expression of iNOS on microglia and p-NF-kappaB/p65 on astrocytes in spinal cords, accompanied by the inhibition of inflammatory factors IL-1beta and TNF-alpha. fasudil 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 23568217-4 2013 Although oxymatrine decreased LPS-induced p65 nuclear translocation and binding to the Cxcl2 gene promoter, this effect was independent of IkappaBalpha degradation/phosphorylation. oxymatrine 9-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 42-45 22899404-6 2012 In addition, reduction of pro-inflammatory mediators by treatment with methylalpinumisoflavone prior to treatment with LPS was accompanied by a decrease in translocation of NF-kappaB p50 and p65 from the cytoplasm to the nucleus and by a decrease in activation of mitogen-activated protein kinases (MAPKs), such as ERK1/2 and JNK. methylalpinumisoflavone 71-94 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 191-194 22842666-4 2012 Pterostilbene also reduced TPA-induced phosphorylation of IkappaBalpha and p65 and caused subsequent degradation of IkappaBalpha. pterostilbene 0-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 75-78 23037503-11 2012 Tissue microarray of mouse tumors showed that parthenolide decreased scores of the cell proliferation marker Ki67 and p65/NF-kB, whereas it increased p21 expression. parthenolide 46-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-121 22994384-4 2012 Fasudil inhibited TLR-4, p-NF-kB/p65, and inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and enhanced IL-10 production in spinal cords. fasudil 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-36 22842666-4 2012 Pterostilbene also reduced TPA-induced phosphorylation of IkappaBalpha and p65 and caused subsequent degradation of IkappaBalpha. Tetradecanoylphorbol Acetate 27-30 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 75-78 22890222-4 2012 Chromatin immunoprecipitation assay confirmed that curcumin inhibits the binding of p65 to TREM-1 promoter in response to LPS. Curcumin 51-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 23442671-7 2012 beta-Carotene also suppressed (p<0.05) NF-kappaB (p50 and p65), phosphorylation of extracellular-signal-related kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) expression. beta Carotene 0-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 61-64 22971898-14 2012 Nitidine chloride inhibits LPS-induced TNF alpha, IL-1beta and IL-6 production via the suppression of phosphorylation of MAPK and the translocation of p65. nitidine 0-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 151-154 22956516-9 2012 Western blot analyses also demonstrated that IGF1 and the combined treatment of cAMP and IGF1 decreased NF-kappaB p65 phosphorylation and increased NF-kappaB p52 levels. Cyclic AMP 80-84 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-117 22749847-6 2012 Moreover, we found that nuclear translocation of p65 and c-Rel, which is critical for Foxp3 and CD25 expressions, was markedly decreased in Tregs with curcumin stimulation. Curcumin 151-159 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 49-52 22344225-10 2012 Nuclear translocation and transcriptional activity of p65 NF-kappaB, an important inducer of EMT, were inhibited by resveratrol. Resveratrol 116-127 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 54-67 23311164-13 2012 The pretreatment with puerarin could inhibit the expression of TNF-alpha and MIP-2 in cell supernatant and NF-kappaB p65 mRNA in cells (P < 0.05). puerarin 22-30 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-120 22915067-2 2012 The binding of zymosan with its specific Toll-like receptors (TLR2 and TLR6) on leukocytes initiates activation and phosphorylation of nuclear factor (NF)-kappaB, which leads to accumulation of NF-kappaB p65 subunits in the nucleus and subsequently up-regulation of the proinflammatory cytokine genes expression. Zymosan 15-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 204-207 23107715-5 2012 Furthermore, it was demonstrated that phloretin suppressed the nuclear translocation of NF-kappaB subunit p65 proteins, and decreased phosphorylation in MAPK pathways. Phloretin 38-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 106-109 22804247-7 2012 Selenite, the source of essential micronutrient selenium, could inhibit NF-kappaB p65 nuclear translocation and subsequently reduce iNOS, COX-2 and TNF-alpha expression in LPS-treated BV2 cells in a dose dependant manner. Selenious Acid 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 22804247-7 2012 Selenite, the source of essential micronutrient selenium, could inhibit NF-kappaB p65 nuclear translocation and subsequently reduce iNOS, COX-2 and TNF-alpha expression in LPS-treated BV2 cells in a dose dependant manner. Selenium 48-56 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 22687552-6 2012 PCP induced the phosphorylation of ERK, JNK, and p38, and the nuclear translocation of NF-kappaB p50/p65, which are the main signaling molecules downstream from TLR4. pcp 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-104 22262470-5 2012 An active form of p65 phosphorylated at serine 536 was present mainly in the nucleus in not only differentiated tumor cells but also tumor-associated stromal cells and bone-resorbing osteoclasts. Serine 40-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 18-21 22181855-6 2012 Immunoblot analysis demonstrated that oral feeding of PFE to mice inhibited UVB-induced (1) nuclear translocation and phosphorylation of nuclear factor kappa B/p65, (2) phosphorylation and degradation of IkappaBalpha, (3) activation of IKKalpha/IotaKappaKappabeta and (4) phosphorylation of mitogen-activated protein kinase proteins and c-Jun. Coconut Oil 54-57 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 160-163 22542583-5 2012 Molecular signaling pathway studies showed that paeonol inhibited the translocation of nuclear factor-kappaB (NF-kappaB) p65 and p50 subunits to the nucleus by blocking IKKalpha/beta (IkappaB kinase alpha/beta) mediated degradation of IkappaBalpha. paeonol 48-55 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-124 22753231-8 2012 EGCG treatment reduced nuclear translocation of NF-kappaB p65 in aortic vessels, decreased blood pressure and serum concentrations of cholesterol and triglycerides in db/db-EGCG mice. epigallocatechin gallate 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 58-61 22732655-9 2012 Glycine alone stimulated NF-kappaB activation in an unusual way such that the inhibitor kappaB-beta (IkappaB-beta) degradation was more significant than that of the inhibitor kappaB-alpha (IkappaB-alpha) and led to NF-kappaB complexes comprised of p50 and p65 subunits; IkappaB-epsilon degradation did not affect by glycine. Glycine 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 256-259 22761446-6 2012 Among several phosphorylation residues in RelA, Thr-254 was identified as the critical phosphorylation site for GSK-3 that modulated chondrocyte differentiation. Threonine 48-51 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 42-46 22761446-7 2012 In conclusion, redundant functions of GSK-3alpha and GSK-3beta through phosphorylation of RelA at Thr-254 play a crucial role in early stages of chondrocyte differentiation. Threonine 98-101 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-94 22683839-9 2012 D-Galactose treatment up-regulated the activity, mRNA expression and protein production of nuclear factor-kappaB (NF-kappaB) p65, Bax and cleaved caspase-3 (P<0.05), as well as suppressed Bcl-2 production (P<0.05). Galactose 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 125-128 22683839-10 2012 Oleanolic acid intake at 0.1% and 0.2% suppressed NF-kappaB p65, Bax and cleaved caspase-3 production, and retained Bcl-2 expression (P<0.05). Oleanolic Acid 0-14 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 60-63 22564506-7 2012 In addition, santamarin suppressed the phosphorylation and degradation of IkappaB-alpha as well as the nuclear translocation of p65 in response to LPS in RAW264.7 cells. santamarine 13-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-131 22553199-1 2012 TMF/ARA160 is a Golgi-associated protein with several cellular functions, among them direction of the NF-kappaB subunit, p65 RelA, to ubiquitination and proteasomal degradation in stressed cells. ara160 4-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-124 22463588-7 2012 Our results also showed that the COX-2 induction by arsenite and UVB depended on an NFkappaB pathway because COX-2 co-induction could be attenuated in either p65-deficient or p50-deficient cells. arsenite 52-60 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 158-161 22587999-8 2012 RESULTS: Administration of RU486 resulted in increased phospho-IkappaB levels and nuclear translocation of p65 in decidual stromal cells, accompanied by the up-regulation of NF-kappaB inducing kinase and IkappaB kinase beta mRNA. Mifepristone 27-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-110 22587999-11 2012 RU486 stimulated recruitment of NF-kappaB p65 to the MMP9 promoter and further increased its expression. Mifepristone 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 42-45 22200888-7 2012 TMP significantly attenuated the damage caused by OXZ and substantially reduced the rise in MPO activity, TNF-alpha, iNOS, NF-kappaB p65 and COX-2 expression, as well as the increase in PPAR-gamma production; however, no changes in the activation of p38 MAPK were observed. tetramethylpyrazine 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 133-136 22552693-6 2012 Both p65 siRNA and curcumin mediated suppression of activation of the NF-kappaB signaling pathway via inhibition of the expression of p65 or IkappaBalpha phosphorylation in ESCC cell lines. Curcumin 19-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 134-137 22552693-7 2012 The cells treated with combination of p65 siRNA or curcumin and 5-FU revealed a lower cell viability and higher apoptosis compared to those treated with 5-FU alone. Fluorouracil 153-157 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 38-41 22552693-10 2012 Overall, our results indicate that the constitutively activated NF-kappaB signaling pathway plays a crucial role in these two ESCC cell lines and both p65siRNA and curcumin can promote ESCC cell apoptosis and enhance the sensitivity to 5-FU through suppression of the NF-kappaB signaling pathway. Fluorouracil 236-240 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 151-154 22510152-5 2012 DHAP potently inhibited the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-kappaB (NF-kappaB) p65 in LPS-stimulated cells. Dihydroxyacetone Phosphate 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 160-163 22570747-5 2012 EGCG blocked LPS-induced IkappaBalpha degradation and RelA nuclear translocation. epigallocatechin gallate 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 54-58 22285597-8 2012 We found, by assaying cells treated with LPS and/or DMPO for 15-60 min, that DMPO inhibited the phosphorylation of MAPKs, Akt, and IkappaBalpha, and reduced the NF-kappaB p65 translocation. 5,5-dimethyl-1-pyrroline-1-oxide 52-56 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 171-174 22285597-8 2012 We found, by assaying cells treated with LPS and/or DMPO for 15-60 min, that DMPO inhibited the phosphorylation of MAPKs, Akt, and IkappaBalpha, and reduced the NF-kappaB p65 translocation. 5,5-dimethyl-1-pyrroline-1-oxide 77-81 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 171-174 22608126-6 2012 Furthermore, ES products suppressed nuclear factor (NF)-kappaB RelA (p65)-dependent transcriptional activity, whereas ES products had no effect on the kappaB-binding activity. Einsteinium 13-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 63-67 22608126-6 2012 Furthermore, ES products suppressed nuclear factor (NF)-kappaB RelA (p65)-dependent transcriptional activity, whereas ES products had no effect on the kappaB-binding activity. Einsteinium 13-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-72 22608126-7 2012 These results suggest that ES products suppress the IP-10 gene expression by inhibiting the ISRE- and RelA-dependent transcriptional activities in mouse macrophages. Einsteinium 27-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-106 22155221-7 2012 Pretreatment with aurentiacin prevented the nuclear translocation of p65 by blocking the phosphorylation of I-kappaB kinase (IKK). 2'-hydroxy-4',6'-dimethoxy-3'-methylchalcone 18-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-72 22155221-8 2012 Aurentiacin also attenuated the phosphorylation (Ser536) and acetylation (Lys310) of p65 and phosphorylation of MAPKs. 2'-hydroxy-4',6'-dimethoxy-3'-methylchalcone 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 85-88 22269833-5 2012 Furthermore, RANKL-mediated increase of IKK, IkappaBalpha, and p65 phosphorylation and NF-kappaB-luciferase activity was inhibited by D-pinitol. pinitol 134-143 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 63-66 22552813-7 2012 In addition, the molecular mechanism underlying naringenin-mediated attenuation in BV2 cells has a close relationship to suppressing translocation of the nuclear factor-kappaB (NF-kappaB) p65 subunit into the nucleus and the phosphorylation of Akt and mitogen-activated protein kinases (MAPKs). naringenin 60-70 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 224-227 22414473-13 2012 CONCLUSION: These results suggest that the anti-inflammatory properties of ethanol extract from ZJP might be the results from the inhibition of iNOS, COX-2, IL-6, IL-1beta, and TNF-alpha expression through preventing the nuclear translocation of the NF-kappaB p50 and p65 subunits in RAW 264.7 cells. Ethanol 75-82 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 268-271 22414473-13 2012 CONCLUSION: These results suggest that the anti-inflammatory properties of ethanol extract from ZJP might be the results from the inhibition of iNOS, COX-2, IL-6, IL-1beta, and TNF-alpha expression through preventing the nuclear translocation of the NF-kappaB p50 and p65 subunits in RAW 264.7 cells. zjp 96-99 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 268-271 22391342-7 2012 ERK inhibitor blocked the interaction of PARP-1 with ERK1/2, phosphorylation of PARP-1, and poly(ADP-ribosyl)ation of p65, suggesting that ERK-dependent phosphorylation of PARP-1 regulates PARP-1 activity and NF-kappaB activation. poly(adp-ribosyl) 92-109 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-121 22155163-8 2012 Sulforaphane inhibited TNF-alpha-induced IotakappaBeta kinase activation, subsequent degradation of IotakappaBetaalpha and nuclear translocation of p65 NF-kappaB and decreased c-Jun and c-Fos protein level. sulforaphane 0-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 148-161 22339795-9 2012 4-O-methylhonokiol also inhibited transcriptional and DNA binding activity of NF-kappaB via inhibition of IkappaB degradation as well as p50 and p65 translocation into nucleus of the brain and cultured astrocytes. 4-O-methylhonokiol 0-18 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 145-148 22490838-6 2012 Quinazoline inhibited the activation of NF-kappaB with a reduction of p-p65 and p-p65/p65 in N2a/APP695 cells and increased the BACE1 protein level. Quinazolines 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 22102286-5 2012 It is surprising that LNT-S enhanced LPS-induced NF-kappaB p65 nuclear translocation and NF-kappaB luciferase activity, but severely inhibited the phosphorylation of JNK1/2 and ERK1/2. Lentinan 22-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-62 21682651-7 2012 This study also reveals that andrographolide treatment could alter the production and expression of proinflammatory cytokines and could inhibit the activation and nuclear translocation of p65, p50, and c-Rel subunits of nuclear factor-kappaB (NF-kappaB), and other transcription factors such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response element-binding protein in B16F-10 melanoma cells. andrographolide 29-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 188-191 21682651-7 2012 This study also reveals that andrographolide treatment could alter the production and expression of proinflammatory cytokines and could inhibit the activation and nuclear translocation of p65, p50, and c-Rel subunits of nuclear factor-kappaB (NF-kappaB), and other transcription factors such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response element-binding protein in B16F-10 melanoma cells. Cyclic AMP 340-370 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 188-191 22186294-4 2012 5-FU was used to investigate whether knockdown NF-kappaB p65 can potentiate 5-FU"s antitumor effect. Fluorouracil 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 57-60 22186294-4 2012 5-FU was used to investigate whether knockdown NF-kappaB p65 can potentiate 5-FU"s antitumor effect. Fluorouracil 76-80 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 57-60 23243434-7 2012 TSAV (200 mg/kg) also significantly decreased Bak, Bax mRNA and Fas, FasL, p53, and NF-kappaB p65 protein expressions and increased Bcl-2 mRNA and protein expressions. tsav 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 94-97 22186294-5 2012 Animal results indicated that tumor growth was inhibited in p65 siRNA and p65 siRNA+5-FU groups as compared with the control group. Fluorouracil 84-88 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-77 22186294-7 2012 Overall, our work indicates that downregulation of p65 can increase tumor apoptosis and potentiates the effects of 5-FU by suppressing NF-kappaB signaling pathway. Fluorouracil 115-119 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 22189654-8 2012 The effect of bindarit is mediated by the downregulation of the classical NFkappaB pathway, involving a reduction of IkappaBalpha and p65 phosphorylation, a reduced activation of NFkappaB dimers and a subsequently reduced nuclear translocation and DNA binding. bindarit 14-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 134-137 22189654-9 2012 Bindarit showed a specific inhibitory effect on the p65 and p65/p50 induced MCP-1 promoter activation, with no effect on other tested activated promoters. bindarit 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 52-55 22189654-9 2012 Bindarit showed a specific inhibitory effect on the p65 and p65/p50 induced MCP-1 promoter activation, with no effect on other tested activated promoters. bindarit 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 60-63 22244329-6 2012 H(2)S acts by sulfhydrating the p65 subunit of NF-kappaB at cysteine-38, which promotes its binding to the coactivator ribosomal protein S3 (RPS3). Hydrogen Sulfide 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 32-35 22244329-6 2012 H(2)S acts by sulfhydrating the p65 subunit of NF-kappaB at cysteine-38, which promotes its binding to the coactivator ribosomal protein S3 (RPS3). Cysteine 60-68 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 32-35 22155740-9 2012 RESULTS: Administration of parthenolide significantly reduced the severity of DSS-induced colitis as assessed by DAI and histological score, and resulted in downregulation of MPO activity and phospho-NF-kappaB p65 expression by the blockade of phosphorylation and subsequent degradation of IkappaB protein, strikingly reduced the production of TNF-alpha and IL-1beta. parthenolide 27-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 210-213 22454678-4 2012 Zuonin B attenuated NF-kappaB (NF-kappaB) activation via suppressing proteolysis of inhibitor kappa B-alpha (IkappaB-alpha) and p65 nuclear translocation as well as phosphorylation of extracellular signal-regulated kinase 1/2 and c-Jun N-terminal kinase. Zuonin B 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-131 23394444-10 2012 A significant increase in the protein levels of p53, c-jun, and NF-kappaB (p65) were observed in DMBA-treated mice, whereas low levels of these markers were observed in DMBA+AQCE-treated animals. 9,10-Dimethyl-1,2-benzanthracene 97-101 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 75-78 22155103-3 2012 Treatment with SF decreased the luciferase activities of NF-kappaB reporter promoters in a dose-dependent manner and translocation of NF-kappaB p65. saucerneol F 15-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 144-147 21947658-5 2012 Since, the induction of NFkB-p65 and inducible nitric oxide synthase expression mediated can lead to the hyperproliferation, we estimated a significant increment (P < 0.001) in the synthesis of polyamines in mice skin evidenced here by the ornithine decarboxylase which is the early marker of tumour promotion and further evaluated PCNA expression. Polyamines 197-207 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 29-32 22984593-8 2012 The phosphorylation of AKT and p65 at serine 536 but not serine 468 was enhanced obviously by NCTD in a dose dependent manner, whereas the degradation of IkappaBalpha was little effected. Serine 38-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-34 23125487-8 2012 RESULTS: A significant improvement was observed in DAI and histological score in mice treated with picroliv, and incerased MPO activity, MDA concentrations, and the expression of IL-1beta, TNF-alpha, and NF-kappaB p65 in mice with DSS-induced colitis were significantly reduced while decreased SOD level increased following administration of picroliv. kutkin 99-107 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 214-217 23284853-3 2012 Therefore, transcription of aa-nat driven by NF-kappaB dimers containing RelA or c-Rel subunits mediates pathogen-associated molecular patterns (PAMPs) or pro-inflammatory cytokine-induced melatonin synthesis in macrophages. Melatonin 189-198 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-77 21802165-8 2011 Augmented synthesis of NO and IL-6 was prevented by treatment with Polymyxin B, or by exposure to a specific NF-kappaB p65 oligonucleotide antisense, indicating the involvement of TLR4-mediated NF-kappaB activation in the unleashed pro-inflammatory response triggered by TNFRp55 deficiency. Oligonucleotides 123-138 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-122 22768070-9 2012 Consistently, supplementation of palmitoleate decreased the phosphorylation of nuclear factor kappa B (NF-kappaB, p65) and the expression of proinflammatory cytokines. palmitoleic acid 33-45 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-117 22768070-12 2012 Palmitoleate also decreased the phosphorylation of NF-kappaB p65 and the expression of proinflammatory cytokines in cultured macrophages. palmitoleic acid 0-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 61-64 21769544-4 2011 LPS induced RelA/NF-kappaB p65 activation, iNOS and COX-2 up-regulations, resulting in NO and prostacyclin releases. Epoprostenol 94-106 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 12-16 21899910-4 2011 Furthermore, SDEE suppressed the IL-1beta/IFN-gamma- or STZ-induced p65 expression of NF-kappaB, which is associated with inhibition of IkappaB-alpha degradation. sdee 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 21899910-4 2011 Furthermore, SDEE suppressed the IL-1beta/IFN-gamma- or STZ-induced p65 expression of NF-kappaB, which is associated with inhibition of IkappaB-alpha degradation. Streptozocin 56-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 22563373-9 2012 Furthermore, farrerol markedly attenuated the activation of phosphorylation of Akt and nuclear factor-kappaB (NF-kappaB) subunit p65 both in vivo and in vitro. farrerol 13-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 129-132 22312446-6 2012 Here, we report that CS extract activates MSK1 in human lung epithelial (H292 and BEAS-2B) cell lines, human primary small airway epithelial cells (SAEC), and in mouse lung, resulting in phosphorylation of nuclear MSK1 (Thr581), phospho-acetylation of RelA/p65 at Ser276 and Lys310 respectively. Cesium 21-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 252-256 22312446-6 2012 Here, we report that CS extract activates MSK1 in human lung epithelial (H292 and BEAS-2B) cell lines, human primary small airway epithelial cells (SAEC), and in mouse lung, resulting in phosphorylation of nuclear MSK1 (Thr581), phospho-acetylation of RelA/p65 at Ser276 and Lys310 respectively. Cesium 21-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 257-260 22312446-8 2012 MSK1 N- and C-terminal kinase-dead mutants, MSK1 siRNA-mediated knock-down in transiently transfected H292 cells, and MSK1 stable knock-down mouse embryonic fibroblasts significantly reduced CS extract-induced MSK1, NF-kappaB RelA/p65 activation, and posttranslational modifications of histones. Cesium 191-193 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 226-230 22312446-8 2012 MSK1 N- and C-terminal kinase-dead mutants, MSK1 siRNA-mediated knock-down in transiently transfected H292 cells, and MSK1 stable knock-down mouse embryonic fibroblasts significantly reduced CS extract-induced MSK1, NF-kappaB RelA/p65 activation, and posttranslational modifications of histones. Cesium 191-193 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 231-234 22312446-9 2012 CS extract/CS promotes the direct interaction of MSK1 with RelA/p65 and p300 in epithelial cells and in mouse lung. Cesium 0-2 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-63 22312446-9 2012 CS extract/CS promotes the direct interaction of MSK1 with RelA/p65 and p300 in epithelial cells and in mouse lung. Cesium 0-2 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-67 22312446-9 2012 CS extract/CS promotes the direct interaction of MSK1 with RelA/p65 and p300 in epithelial cells and in mouse lung. Cesium 11-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-63 22312446-9 2012 CS extract/CS promotes the direct interaction of MSK1 with RelA/p65 and p300 in epithelial cells and in mouse lung. Cesium 11-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-67 21940942-7 2011 Deacetylated FoxO1 inhibits free cholesterol-induced Akt phosphorylation and increases levels of the nuclear factor-kappaB precursor p105, decreasing nuclear translocation of nuclear factor-kappaB p65 subunit and dampening mitogen-activated protein/extracellular signal-regulated kinase activation to prevent inflammation. Cholesterol 33-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 197-200 21952584-6 2011 Relative to overweight control, DIO increased whereas 30% CR reduced activation of Akt, mTORC1, STAT3, and NFkappaB (p65) in ventral prostate. Chromium 58-60 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-120 22200709-8 2011 Melatonin can reduce the expression levels of NF-kappaB p65 and synaptophysin in the brain tissue to protect the brain and slow down the aging process. Melatonin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 56-59 21809375-7 2011 In addition, it was found that pretreatment with roxatidine significantly inhibited the nuclear translocations of the p65 and p50 subunits of NF-kappaB, and these inhibitions were not found to be associated with decreases in the phosphorylation or degradation of inhibitory kappa B-alpha (IkappaBalpha). roxatidine acetate 49-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-121 22024029-9 2011 Marked increase in the nuclear translocation of p65, and the phosphorylation and degradation of IkappaB-alpha were also observed in ascophyllan-treated RAW264.7 cells. ascophyllin 132-143 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 48-51 22199113-10 2011 Curcumin treatment inhibited the elevation of NF-kappaB-p65 in the nucleus of mouse pancreas AP group and RAW264.7 cells, but significantly increased the expression of PPARgamma. Curcumin 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 56-59 22037580-9 2011 Furthermore, treatment with this limonoid suppressed RANKL-induced activation of p38, MAPK and Erk and nuclear localization of NF-kappaB p65. Limonins 33-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 137-140 22110409-5 2011 Conversely, uncoupling RelA degradation from gammaHV68 infection promoted NFkappaB activation and elevated cytokine production. gammahv68 45-54 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 23-27 21999414-10 2011 We show that the criterion for validation by use of blocking peptides can still fail the test of specificity, as demonstrated for several antibodies raised against p65 phosphorylated at serine 276. Serine 186-192 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 164-167 21989142-10 2011 DSS-induced IkappaBalpha phosphorylation/degradation and phosphorylation of NF-kappaB/p65 were blocked by BTE. Dextran Sulfate 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 86-89 21443976-4 2011 Interestingly, the suppression of NF-kappaB activation by these flavonoids is due to inhibition of the transcriptional activation of NF-kappaB, since the compounds markedly inhibited the transcriptional activity of GAL4-NF-kappaB p65 fusion protein. Flavonoids 64-74 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 230-233 21596132-3 2011 Here, we investigated whether BAFF expression could be regulated by p65 phosphorylation through the production of reactive oxygen species (ROS) or cyclic AMP (cAMP) in Raw264.7 murine macrophages. Reactive Oxygen Species 114-137 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 21596132-3 2011 Here, we investigated whether BAFF expression could be regulated by p65 phosphorylation through the production of reactive oxygen species (ROS) or cyclic AMP (cAMP) in Raw264.7 murine macrophages. Reactive Oxygen Species 139-142 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 21496499-5 2011 The treatment with tetrandrine resulted in downregulation of phospho NF-kappaB p65 expression and strikingly reduced the production of IL-1beta and TNF-alpha. tetrandrine 19-30 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 79-82 21982455-8 2011 Further, 2,4-bis(p-hydroxyphenyl)-2-butenal inhibited the transcriptional and DNA binding activity of NF-kappaB--a transcription factor that regulates genes involved in neuroinflammation and amyloidogenesis via inhibition of IkappaB degradation as well as nuclear translocation of p50 and p65. 2,4-bis(p-hydroxyphenyl)-2-butenal 9-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 289-292 21671066-4 2011 In particular, glyceollins suppressed the LPS-induced phosphorylation of NF-kB p65, suggesting that the compounds inhibit the production of NO and transcriptional activation of COX-2 by regulating NF-kB activity. glyceollin 15-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 79-82 21596132-6 2011 Serine (Ser) 276 phosphorylation of p65 was increased by LPS-mediated PKA activation or by the treatment with forskolin, adenylate cyclase activator and dibutyl-cAMP. Serine 0-6 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 36-39 21596132-6 2011 Serine (Ser) 276 phosphorylation of p65 was increased by LPS-mediated PKA activation or by the treatment with forskolin, adenylate cyclase activator and dibutyl-cAMP. Serine 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 36-39 21596132-6 2011 Serine (Ser) 276 phosphorylation of p65 was increased by LPS-mediated PKA activation or by the treatment with forskolin, adenylate cyclase activator and dibutyl-cAMP. Colforsin 110-119 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 36-39 21596132-6 2011 Serine (Ser) 276 phosphorylation of p65 was increased by LPS-mediated PKA activation or by the treatment with forskolin, adenylate cyclase activator and dibutyl-cAMP. Bucladesine 153-165 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 36-39 21596132-7 2011 In contrast, p65 phosphorylation at Ser276 was decreased by ROS scavengers. Reactive Oxygen Species 60-63 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 13-16 21596132-15 2011 Data demonstrate that TLR4-mediated mBAFF expression was resulted from the crosstalk of p65 phosphorylation at Ser536 and Ser276 through ROS- and/or cAMP-mediated signal transduction. Reactive Oxygen Species 137-140 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 21596132-15 2011 Data demonstrate that TLR4-mediated mBAFF expression was resulted from the crosstalk of p65 phosphorylation at Ser536 and Ser276 through ROS- and/or cAMP-mediated signal transduction. Cyclic AMP 149-153 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 21737676-0 2011 The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration. Threonine 23-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 12-16 21496491-6 2011 Mechanistically, UA markedly inhibited LPS-induced IkappaBalpha phosphorylation and degradation, NF-kappaB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt. ursolic acid 17-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-110 21737676-0 2011 The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration. Threonine 23-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 18-21 21737676-3 2011 Using rela(-/-) mouse embryonic fibroblasts reconstituted with RelA, we find that mutation of the threonine 505 (T505) phospho site to alanine has wide-ranging effects on NF-kappaB function. Threonine 98-107 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 6-10 21737676-3 2011 Using rela(-/-) mouse embryonic fibroblasts reconstituted with RelA, we find that mutation of the threonine 505 (T505) phospho site to alanine has wide-ranging effects on NF-kappaB function. Alanine 135-142 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 6-10 21737676-6 2011 We also define a new component of cisplatin-induced, RelA T505-dependent apoptosis, involving induction of NOXA gene expression, an effect explained at least in part through induction of the p53 homologue, p73. Cisplatin 34-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-57 21874163-4 2011 In murine lung adenocarcinoma cell lines with high NF-kappaB activity, the proteasome inhibitor bortezomib efficiently reduced nuclear p65, repressed NF-kappaB target genes, and rapidly induced apoptosis. Bortezomib 96-106 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 135-138 21787749-7 2011 Y-27632 attenuated thrombin-mediated phosphorylation of p38MAPK and p65, indicating that Rho-kinase mediates thrombin-induced MCP-1 expression through p38MAPK and NF-kappaB activation. Y 27632 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 22111069-5 2011 LPS-induced inhibitor kappa B alpha (IkappaBalpha) degradation and nuclear translocation of RelA were blocked by theaflavin. theaflavin 113-123 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 92-96 21530968-10 2011 Administration of resveratrol decreased protein expression of phospho-p65 in AAA. Resveratrol 18-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 21474329-8 2011 BEX significantly ameliorated PA-induced upregulation of IL-6 mRNA, which correlated with a reduction in nuclear translocation of p50, p65, and c-fos proteins with the presence of BEX, indicating inhibition of NF-kappaB and AP-1 activation. BEX 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 135-138 20643202-10 2011 Curcumin stabilized IkappaBalpha and inhibited nuclear translocation of p65 and p50 in LPS-activated Raw264.7 cells, and curcumin-treated mice showed reduced nuclear translocation of p65 in lung tissue. Curcumin 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 20643202-10 2011 Curcumin stabilized IkappaBalpha and inhibited nuclear translocation of p65 and p50 in LPS-activated Raw264.7 cells, and curcumin-treated mice showed reduced nuclear translocation of p65 in lung tissue. Curcumin 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 183-186 20643202-10 2011 Curcumin stabilized IkappaBalpha and inhibited nuclear translocation of p65 and p50 in LPS-activated Raw264.7 cells, and curcumin-treated mice showed reduced nuclear translocation of p65 in lung tissue. Curcumin 121-129 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 183-186 21474329-8 2011 BEX significantly ameliorated PA-induced upregulation of IL-6 mRNA, which correlated with a reduction in nuclear translocation of p50, p65, and c-fos proteins with the presence of BEX, indicating inhibition of NF-kappaB and AP-1 activation. Palmitic Acid 30-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 135-138 21593200-0 2011 Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation. Serine 112-118 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 106-110 21481872-8 2011 Although serum MCP-1 and MIF concentrations were not changed by either statins, atorvastatin administration increased PPAR-alpha and -gamma mRNA abundances and decreased NF-kappaB p50, p65, MCP-1 and TNF-alpha mRNA abundances in atherosclerotic lesions. Atorvastatin 80-92 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 185-188 21593200-6 2011 A chromatin immunoprecipitation assay was performed to analyze the effects of Klotho signaling on interleukin-8 and monocyte chemoattractant protein-1 promoter recruitment of RelA and RelA serine (Ser)(536). Serine 189-195 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 184-188 21593200-9 2011 Klotho specifically inhibited RelA Ser(536) phosphorylation as well as promoter DNA binding of this phosphorylated form of RelA without affecting IKK-mediated IkappaBalpha degradation, total RelA nuclear translocation, and total RelA DNA binding. Serine 35-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 30-34 21593200-10 2011 CONCLUSIONS: These findings suggest that Klotho serves as an anti-inflammatory modulator, negatively regulating the production of NF-kappaB-linked inflammatory proteins via a mechanism that involves phosphorylation of Ser(536) in the transactivation domain of RelA. Serine 218-221 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 260-264 21470577-6 2011 Furthermore, kinsenoside inhibited the NF-kappaB activation induced by LPS, and this is associated with the abrogation of IkappaBalpha degradation, with subsequent decreases in nuclear p65 and p50 protein levels. 3-glucopyranosyloxybutanolide 13-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 185-188 21699753-5 2011 Phosphorylation of the pro-inflammatory transcription factor complex nuclear factor-kappa B (NF-kappaB) p65 and expression of inducible nitric oxide synthase (iNOS), one of its downstream proteins, were also suppressed by DCM fraction. Methylene Chloride 222-225 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 104-107 21811692-11 2011 Curcumin also attenuated DNA binding activity of p50 and p65 subunits and suppressed STAT1 phosphorylation. Curcumin 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 57-60 21725879-7 2011 With cells treated with a combination of BCG and PPS, the expression of genes associated with the NF-kappaB signaling pathway, such as IKBKB, ICAM1 and CCL2, were all down-regulated compared to the BCG group, as well as Rel A mRNA expression, NF-kappaB p65 DNA-binding activity and NF-kappaB p65 nuclear expression. pps 49-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 220-225 21649480-6 2011 The study also reveals that vernolide-A treatment could alter the production and expression of proinflammatory cytokines and could inhibit the activation and nuclear translocation of p65, p50, and c-Rel subunits of nuclear factor-kappaB and other transcription factors, such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response-element-binding protein in B16F-10 melanoma cells. vernolide-A 28-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 183-186 21649480-6 2011 The study also reveals that vernolide-A treatment could alter the production and expression of proinflammatory cytokines and could inhibit the activation and nuclear translocation of p65, p50, and c-Rel subunits of nuclear factor-kappaB and other transcription factors, such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response-element-binding protein in B16F-10 melanoma cells. Cyclic AMP 323-353 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 183-186 21549115-8 2011 Baicalein inhibited COX-2 and NF-kappaB/p65 expression, but stimulated HIF-1alpha expression. baicalein 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-43 21502320-7 2011 However, mGBP-2 inhibits p65 binding to a kappaB oligonucleotide probe in gel shift assays and to the MMP-9 promoter in chromatin immunoprecipitation assays. Oligonucleotides 49-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 25-28 21585385-11 2011 Eugenosedin-A, like atorvastatin, could inhibit p38, ERK, JNK, Akt/IKKalpha/p65 proteins, as well as TNF-alpha and IFN-gamma mRNA during the regulation of the obesity-induced inflammatory process. eugenosedin-A 0-13 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 76-79 21480506-8 2011 Moreover, significant increases in the protein levels analyzed by ELISA of c-Jun, p65, and p53 were observed in the skin of DMBA/TPA treated mice, whereas mice treated with 2 and DMBA/TPA had a similar expression of these transcription factors than the control mice. 9,10-Dimethyl-1,2-benzanthracene 124-128 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 21406501-11 2011 This mechanism is responsible for inhibition of glyceroneogenesis in adipocytes, which contributes to lipodystrophy in the aP2-p65 Tg mice. glyceroneogenesis 48-65 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 127-130 21164518-5 2011 We show that glucose-induced anti-apoptotic genes are dependent on NF-kappaB p65 because high glucose is unable to attenuate normal ongoing apoptosis of thymocytes isolated from p65 knockout mice. Glucose 13-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-80 21164518-5 2011 We show that glucose-induced anti-apoptotic genes are dependent on NF-kappaB p65 because high glucose is unable to attenuate normal ongoing apoptosis of thymocytes isolated from p65 knockout mice. Glucose 13-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 178-181 21480506-8 2011 Moreover, significant increases in the protein levels analyzed by ELISA of c-Jun, p65, and p53 were observed in the skin of DMBA/TPA treated mice, whereas mice treated with 2 and DMBA/TPA had a similar expression of these transcription factors than the control mice. Tetradecanoylphorbol Acetate 129-132 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 21335487-5 2011 Salmeterol significantly inhibited LPS-induced production of microglial proinflammatory neurotoxic mediators, such as TNF-alpha, superoxide, and NO, as well as the inhibition of TAK1-mediated phosphorylation of MAPK and p65 NF-kappaB. Salmeterol Xinafoate 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 220-233 21237302-7 2011 Moreover, treatment with TA decreased LPS-induced DNA binding of nuclear factor-kappa B (NF-kappaB) and nuclear translocation of p65 and p50 subunits of NF-kappaB. lps 38-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 129-132 21227469-12 2011 In comparison with group 3, triptolide reduced NF-kappaB p65 nuclear and IkappaBalpha expression, and effectively suppressed pro-inflammatory cytokine level during the I/R. triptolide 28-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 57-60 21199676-10 2011 Furthermore, the phosphorylation level of NF-kappaB p65 was markedly decreased by bicyclol. bicyclol 82-90 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 52-55 21176770-4 2011 Here we show that exposure of mouse embryonic fibroblasts to TNFalpha or LPS led to a marked induction of PAI-1, which was blunted by 1,25(OH)2D3, NF-kappaB inhibitor or p65 siRNA, suggesting the involvement of NF-kappaB in 1,25(OH)2D3-induced repression. Calcitriol 224-235 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 170-173 21264946-7 2011 Our data show dynamic changes of PlGF expression, from periaxonal in normal nerve to SCs 24h postinjury, in parallel with a p65/NF-kappaB recruitment on Pgf promoter. Prostaglandins F 153-156 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 124-137 21408125-6 2011 Western blot analysis showed propofol inhibited LPS-induced activation and phosphorylation of IKKbeta (Ser180) and nuclear factor (NF)-kappaB (Ser536); the subsequent nuclear translocation of NF-kappaB p65 was also reduced. Propofol 29-37 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 202-205 21144805-5 2011 KU55933 suppressed IR-induced IkappaBalpha degradation, p50/p65 nuclear translocation and binding to kB consensus sequences. 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 60-63 21114991-5 2011 BHMC inhibited p65 NF-kappaB nuclear translocation and DNA binding of p65 NF-kappaB only at the highest concentration used (12.5muM) but failed to alter phosphorylation of JNK, ERK1/2 and STAT-1. bhmc 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 15-18 21114991-5 2011 BHMC inhibited p65 NF-kappaB nuclear translocation and DNA binding of p65 NF-kappaB only at the highest concentration used (12.5muM) but failed to alter phosphorylation of JNK, ERK1/2 and STAT-1. bhmc 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 15-28 20979017-5 2011 The results showed that polydatin treatment downregulated NF- kappaB p65 activity and expression, blocked the expression of TNF- alpha, IL-6 and IL-1 beta at both mRNA and protein levels, decreased myeloperoxidase (MPO) activity, and alleviated inflammatory damage of colitis in mice with UC (p < 0.05), suggesting that the anti-inflammation effects of polydatin can be attributed, at least partially, to the blocking of the NF- kappaB pathway. polydatin 24-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-72 21144805-8 2011 Importantly, KU55933 sensitised IKKbeta(+/+) and p65(+/+), but not IKKbeta(-/-) or p65(-/-), mouse embryonic fibroblasts to IR, despite the equivalent inhibitory effects of KU55933 on DSB repair in both the proficient and the deficient cell lines. 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one 13-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 49-52 21609314-4 2011 The study reveals that andrographolide treatment could inhibit the activation and nuclear translocation of p65, p50, and c-Rel subunits of nuclear factor-kappaB, and other transcription factors such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response element-binding protein in B16F-10 melanoma cells. andrographolide 23-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-110 20661184-3 2011 Furthermore, kinsenoside decreased the formation of a nuclear factor [kappa]B-DNA complex and nuclear p65 and p50 protein levels. 3-glucopyranosyloxybutanolide 13-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-105 21167294-5 2011 Pharmacological inhibition of nuclear factor kappa B (NFkappaB) prevented LPS-induced upregulation of Sptlc2 while transfection of p65 subunit of NFkappaB upregulated Sptlc2 and increased cellular ceramide levels. Ceramides 197-205 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 131-134 21609314-4 2011 The study reveals that andrographolide treatment could inhibit the activation and nuclear translocation of p65, p50, and c-Rel subunits of nuclear factor-kappaB, and other transcription factors such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response element-binding protein in B16F-10 melanoma cells. Cyclic AMP 247-277 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-110 21617754-14 2011 FK506 increased FKBP51, NF-kappaB p65, and levels of activated NF-kappaB p65 protein. Tacrolimus 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 34-37 22046080-8 2011 In addition, our results demonstrated that the expression of NF-kappaB (p65), and the phosphorylation/activation of NF-kappaB (p65) at Ser536 are not significantly changed in the cerebellum and cortex of both autistic subjects and BTBR mice. btbr 231-235 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 127-130 21617754-14 2011 FK506 increased FKBP51, NF-kappaB p65, and levels of activated NF-kappaB p65 protein. Tacrolimus 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-76 21617754-17 2011 Both FK506 and FKBP51 appear to act through activation of NF-kappaB p65 protein, suggesting a common pathway for neuroprotection. Tacrolimus 5-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 21660860-6 2011 We demonstrate resveratrol inhibits skeletal muscle and cardiac atrophy induced by C26 adenocarcinoma tumors through its inhibition of NF-kappaB (p65) activity in skeletal muscle and heart. Resveratrol 15-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 146-149 22114683-9 2011 Pre-treatment with rmMFG-E8 significantly reduced LPS-induced NF-kappaB p65 contents. rmmfg-e8 19-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 21194439-12 2010 However, GSK-3beta inactivation inhibited transactivation activity of p65 by deacetylating p65 at lysine 310. Lysine 98-104 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 22140508-5 2011 DHA pretreatment also attenuated UVB-induced DNA binding of nuclear factor-kappaB (NF-kappaB) through the inhibition of phosphorylation of IkappaB kinase-alpha/beta, phosphorylation and degradation of IkappaBalpha and nuclear translocation of p50 and p65. Docosahexaenoic Acids 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 251-254 22140508-6 2011 In addition, UVB-induced phosphorylation of p65 at the serine 276 residue was significantly inhibited by topical application of DHA. Serine 55-61 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 44-47 22140508-6 2011 In addition, UVB-induced phosphorylation of p65 at the serine 276 residue was significantly inhibited by topical application of DHA. Docosahexaenoic Acids 128-131 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 44-47 22069489-10 2011 Resveratrol reduced NF-kappaB subunit RelA/p65 acetylation, which is notably Sirt1 dependent. Resveratrol 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 38-42 22069489-10 2011 Resveratrol reduced NF-kappaB subunit RelA/p65 acetylation, which is notably Sirt1 dependent. Resveratrol 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 43-46 22003398-8 2011 The 15d-PGJ2 also reduced the expression of macrophages and RelA mRNA in atherosclerotic lesions. 15-deoxy-delta(12,14)-prostaglandin J2 4-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 60-64 21194439-12 2010 However, GSK-3beta inactivation inhibited transactivation activity of p65 by deacetylating p65 at lysine 310. Lysine 98-104 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-94 20932499-11 2010 Therefore, our results suggest that astaxanthin regulates IL-6 production through a p-ERK1/2-MSK-1- and p-NF-kappaB p65-dependent pathway in activated microglial cells. astaxanthine 36-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 116-119 21078906-8 2010 In addition, Ron inhibits serine phosphorylation of p65 and NF-kappaB transcriptional activity induced by LPS stimulation of TLR4. Serine 26-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 52-55 20932499-3 2010 Moreover, LPS-induced p-IKKalpha, p-IkappaBalpha, and p-NF-kappaB p65 levels were all suppressed by astaxanthin. astaxanthine 100-111 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 20932499-4 2010 The translocation of p-NF-kappaB p65 from the cytosol into the nucleus and transcriptional activity were inhibited by astaxanthin. astaxanthine 118-129 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-36 21159647-7 2010 Phosphorylation of p65 at Ser276 causing its activation was also significantly augmented in DEN-exposed MTKO livers. Diethylnitrosamine 92-95 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 19-22 21241574-0 2010 [Expression and significance of NF-kappaB p65 in ethanol induced acute liver cell damage in mice]. Ethanol 49-56 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 42-45 20932499-8 2010 In addition, IL-6 suppression through astaxanthin-induced down-regulation of p-ERK1/2, p-MSK1, and p-NF-kappaB p65 occurred in microglial cells stimulated with LPS or stromal derived factor (SDF)-1alpha. astaxanthine 38-49 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 111-114 20932499-10 2010 SDF-1alpha-stimulated ERK1/2, MSK1, and NF-kappaB p65 phosphorylation were reduced by astaxanthin. astaxanthine 86-97 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 50-53 21118574-9 2010 RESULTS: We found that LPS-induced COX-2 expression and PGE2 production were mediated through NF-kappaB (p65) via activation of Toll-like receptor 4 (TLR4). Dinoprostone 56-60 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 105-108 21118574-12 2010 Pretreatment with CO-RM2 also inhibited TLR4/MyD88 complex formation, NF-kappaB (p65) activation, COX-2 expression, and PGE2 production induced by LPS. tricarbonyldichlororuthenium (II) dimer 18-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 81-84 20737476-7 2010 In addition, we found that GlcN strongly repressed p65 transactivation in BV2 cells using Gal4-p65 chimeras system. Glucosamine 27-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 20737476-7 2010 In addition, we found that GlcN strongly repressed p65 transactivation in BV2 cells using Gal4-p65 chimeras system. Glucosamine 27-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-98 20133359-8 2010 Moreover, UA significantly decreased AGEs induced the expression of receptor for advanced glycation end products and inhibited NF-kappaB p65 nuclear translocation in the prefrontal cortex of D-gal-treated mice. ursolic acid 10-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 137-140 20133359-8 2010 Moreover, UA significantly decreased AGEs induced the expression of receptor for advanced glycation end products and inhibited NF-kappaB p65 nuclear translocation in the prefrontal cortex of D-gal-treated mice. Deuterium 191-192 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 137-140 20633530-6 2010 As a mode of action, we showed that glabridin inhibited degradation of IkappaBetaalpha/beta, nuclear translocation of NF-kappaB p65/p50, and phosphorylation of ERK, JNK, and p38 MAPKs. glabridin 36-45 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-131 20509140-3 2010 Addition of dauricine inhibited the phosphorylation and degradation of IkappaBalpha, and the phosphorylation and translocation of p65. dauricine 12-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 130-133 20697819-9 2010 Licofelone treatment also attenuated the expression of apoptotic factor (caspase-3) and transcription factor (NF-kappaB/p65) as compared to MPTP-treated group. licofelone 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 120-123 20519138-6 2010 Western blotting analysis and confocal microscopy showed that icariin pretreatment reduced the nucleus transportation and constant level of NF-kappaB p65 in the RAW 264.7 macrophage cells. icariin 62-69 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 150-153 20542118-6 2010 Western blot analysis found quercetin to maintain cytosolic p65 protein levels to that seen in control. Quercetin 28-37 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 60-63 20542118-8 2010 Immunofluorescence studies revealed quercetin to prevent HG induced nuclear localization of p65 and c-jun. Quercetin 36-45 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 92-95 20519138-4 2010 In addition, icariin suppressed the secretion of TNF-alpha, prostaglandin E2 (PGE(2)) and nitric oxide (NO) as well as NF-kappaB p65 activation. icariin 13-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 129-132 20605904-6 2010 Kidneys from Nrf2-null mice treated with cisplatin had more neutrophil infiltration accompanied by increased p65 nuclear factor kappaB binding and elevated inflammatory mediator mRNA levels. Cisplatin 41-50 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-112 20534383-5 2010 In addition, LPS-induced pro-inflammatory cytokines, including IL-1beta, IL-6, and TNF-alpha, were also decreased by pretreatment with isodojaponin D. This effect was accompanied by a decrease in translocations of Nuclear Factor-KappaB (NF-kappaB) p50 and p65 from the cytoplasm to the nucleus and by a decrease in I kappaB (IkappaB) degradation. isodojaponin 135-147 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 256-259 20609401-3 2010 DMC prevented nuclear translocation of the nuclear factor-kappaB (NF-kappaB) p65 subunit by reducing inhibitor of kappaB alpha (I-kappaB alpha) phosphorylation and degradation, which resulted in a suppression of NF-kappaB activities for its target genes. methyl carbonate 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-80 20554912-9 2010 p65-DNA binding was assessed using electrophoretic mobility shift assay, and it was shown that there was a time-dependent increased binding that was inhibited by means of parthenolide pretreatment or siRNA-mediated p65 gene silencing. parthenolide 171-183 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 0-3 20336681-5 2010 6-Shogaol also reduced TPA-induced phosphorylation of IkappaBalpha and p65, and caused subsequent degradation of IkappaBalpha. Tetradecanoylphorbol Acetate 23-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 71-74 20462523-8 2010 The flavone also inhibited p65-NF-kappaB translocation into the nucleus by I kappaB alpha degradation. flavone 4-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 27-40 20609401-0 2010 Dimethyl cardamonin inhibits lipopolysaccharide-induced inflammatory factors through blocking NF-kappaB p65 activation. 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone 0-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 104-107 20336681-5 2010 6-Shogaol also reduced TPA-induced phosphorylation of IkappaBalpha and p65, and caused subsequent degradation of IkappaBalpha. shogaol 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 71-74 20823682-0 2010 Amelioration of dextran sulfate sodium-induced chronic colitis by sulfasalazine salicylazosulfapyridine via reducing NF-kappaB transcription factor p65 recruitment to ICAM-1 gene promoters. sulfasalazine salicylazosulfapyridine 66-103 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 148-151 20823682-0 2010 Amelioration of dextran sulfate sodium-induced chronic colitis by sulfasalazine salicylazosulfapyridine via reducing NF-kappaB transcription factor p65 recruitment to ICAM-1 gene promoters. Dextran Sulfate 16-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 148-151 20648656-0 2010 Nuclear factor-kappaB/p65 responds to changes in the Notch signaling pathway in murine BV-2 cells and in amoeboid microglia in postnatal rats treated with the gamma-secretase complex blocker DAPT. dapt 191-195 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 22-25 20823682-11 2010 In conclusion, inhibition of NF-kappaB pathway signal proteins and blockade of p65 binding to gene ICAM-1 promoter might explain the effect and mechanisms of SASP at alleviating DSS-induced colitis in mice. Dextran Sulfate 178-181 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 79-82 20623531-4 2010 Glutamate treatment increased NF-kappaB activation along with nuclear expressions of RelA and cRel in wtSOD1 cells but induced only weak nuclear RelA expression in mtSOD1 cells. Glutamic Acid 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 85-89 20623531-4 2010 Glutamate treatment increased NF-kappaB activation along with nuclear expressions of RelA and cRel in wtSOD1 cells but induced only weak nuclear RelA expression in mtSOD1 cells. Glutamic Acid 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 145-149 20623531-8 2010 Our results suggest that glutamate excitotoxicity in motor neurons of SOD1-linked fALS is attributable, at least in part, to the impairment of IkappaBalpha-dependent RelA activation and subsequent apoptosis mediated by XIAP inhibition and caspase-3 activation. Glutamic Acid 25-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 166-170 20538789-5 2010 On the contrary, 17beta-estradiol (E(2)) inhibits LPS-induced MCP-1 production in a time- and dose-dependent manner, which is related to the suppression of p65 translocation to nucleus. Estradiol 17-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 156-159 20472709-6 2010 Neutrophil influx in bronchoalveolar lavage fluid and proinflammatory cytokine release in lung were increased in Glrx1 KO mice compared with WT mice exposed to CS, which was associated with augmented nuclear translocation of RelA/p65 and its phospho-acetylation. Cesium 160-162 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 225-229 20472709-6 2010 Neutrophil influx in bronchoalveolar lavage fluid and proinflammatory cytokine release in lung were increased in Glrx1 KO mice compared with WT mice exposed to CS, which was associated with augmented nuclear translocation of RelA/p65 and its phospho-acetylation. Cesium 160-162 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 230-233 20504883-10 2010 This supposition is supported by increases seen in p65-NF-kappaB, osteopontin, and leukocyte influx in the kidneys of the tempol-treated group. tempol 122-128 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-64 20100194-4 2010 NF-kappaB reporter activities and nuclear translocations of NF-kappaB p65 in cultured keratinocytes stimulated by mezerein were inhibited by pretreatment of the cells with LXA(4). mezerein 114-122 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 20100194-4 2010 NF-kappaB reporter activities and nuclear translocations of NF-kappaB p65 in cultured keratinocytes stimulated by mezerein were inhibited by pretreatment of the cells with LXA(4). N-(1H-benzimidazol-2-ylmethyl)-2-methoxyacetamide 172-175 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 20538789-7 2010 Transfection with p38 MAPK siRNA or the use of p38 MAPK inhibitor SB203580 markedly attenuates LPS-stimulated p65 translocation to nucleus and MCP-1 production, suggesting that E(2) suppresses NFkappaB signaling by the inactivation of p38 MAPK signaling. SB 203580 66-74 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 110-113 20447389-7 2010 Our results revealed that in alloxan-induced diabetic mice, the nuclear staining of NF-kappaB p65 was increased in glomerulus, whereas renal I kappaB-alpha protein was significantly reduced. Alloxan 29-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 94-97 20378317-5 2010 We also showed that atrovirinone prevented phosphorylation of I-kappaBalpha, which resulted in a reduction of p65NF-kappaB nuclear translocation as demonstrated by expression analysis. atrovirinone 20-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 110-122 20672443-6 2010 The observed up-regulation of MYBBP1A, a known repressor of a number of transcription factors such as PGC-1 alpha, C-myb, and p65 of the NF-kappaB family, suggests that this protein might play a role in the mechanism of DON toxicity. deoxynivalenol 220-223 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 126-129 20188786-7 2010 Resveratrol suppressed extracellular receptor-activated kinase (ERK) and transcription factor-kappaB (NF-kappaB) activation by reducing the phosphorylation of ERK1/2 and NF-kappaB p65; moreover, it modulated insulin signaling transduction by modification of Ser/Thr phosphorylation of insulin receptor substrate-1 (IRS-1) and downstream AKT (T308), and thereby improved insulin sensitivity in adiposities. Resveratrol 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 180-183 20351313-5 2010 Treatment with 17-DMAG leads to depletion of the HSP90 client protein IKK, resulting in diminished NF-kappaB p50/p65 DNA binding, decreased NF-kappaB target gene transcription, and caspase-dependent apoptosis. 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin 15-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 113-116 19880966-11 2010 Using real-time PCR we found a significant downregulation of the target genes VEGF and RelA demonstrating our ability to achieve effective pharmacological levels of aspirin and enalapril during pancreatic cancer formation in vivo. Aspirin 165-172 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 87-91 20218615-4 2010 Pretreatment with magnolol resulted in the reduction of TPA-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunit and DNA binding by blocking the phosphorylation of IkappaBalpha and p65 and subsequent degradation of IkappaBalpha. magnolol 18-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 206-209 20218615-4 2010 Pretreatment with magnolol resulted in the reduction of TPA-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunit and DNA binding by blocking the phosphorylation of IkappaBalpha and p65 and subsequent degradation of IkappaBalpha. Tetradecanoylphorbol Acetate 56-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 206-209 20350561-11 2010 TCDD downregulated LPS- and CpG-induced NF-kB p65 levels and induced a trend towards upregulation of RelB levels in the BMDCs. Polychlorinated Dibenzodioxins 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 46-49 20353767-6 2010 Pretreatment of eupatolide inhibited LPS-induced phosphorylation and degradation of I kappaB alpha, and phosphorylation of RelA/p65 on Ser-536 as well as the activation of mitogen-activated protein kinases (MAPKs) and Akt in LPS-stimulated RAW264.7 cells. eupatolide 16-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-131 20353767-6 2010 Pretreatment of eupatolide inhibited LPS-induced phosphorylation and degradation of I kappaB alpha, and phosphorylation of RelA/p65 on Ser-536 as well as the activation of mitogen-activated protein kinases (MAPKs) and Akt in LPS-stimulated RAW264.7 cells. Serine 135-138 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-131 19880966-11 2010 Using real-time PCR we found a significant downregulation of the target genes VEGF and RelA demonstrating our ability to achieve effective pharmacological levels of aspirin and enalapril during pancreatic cancer formation in vivo. Enalapril 177-186 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 87-91 20056147-6 2010 Moreover, silymarin inhibited p65/NF-kappaB phosphorylation in CD4+ T cell. Silymarin 10-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 30-33 20132469-6 2010 Notably, curcumin blocked IL-1beta-induced aquaporin-4 expression in cultured astrocytes, an effect mediated, at least in part, by reduced activation of the p50 and p65 subunits of nuclear factor kappaB. Curcumin 9-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 165-168 20132469-7 2010 Consistent with this notion, curcumin preferentially attenuated phosphorylated p65 immunoreactivity in pericontusional astrocytes and decreased the expression of glial fibrillary acidic protein, a reactive astrocyte marker. Curcumin 29-37 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 79-82 19880242-0 2010 Downregulation of nuclear factor-kappaB p65 subunit by small interfering RNA synergizes with gemcitabine to inhibit the growth of pancreatic cancer. gemcitabine 93-104 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-43 19880242-3 2010 This study aimed to investigate whether downregulation of the p65 subunit of NF-kappaB by siRNA could enhance the efficacy of gemcitabine to treat pancreatic cancer. gemcitabine 126-137 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 62-65 19880242-4 2010 p65 siRNA synergized with gemcitabine to inhibit the proliferation and induce the apoptosis of pancreatic cancer cells in vitro and in vivo, and suppress the growth and angiogenesis of pancreatic tumors in nude mice. gemcitabine 26-37 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 0-3 19880242-6 2010 The results suggest that downregulation of NF-kappaB p65 potentiates the efficacy of gemcitabine in combating pancreatic cancer. gemcitabine 85-96 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 20302656-12 2010 Furthermore, the expression of NF-kappaB p65 in nucleus was markedly suppressed by butyrate pretreatment. Butyrates 83-91 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 41-44 20068030-7 2010 Exposure of mouse macrophages to HE3286 in vitro caused partial suppression of endotoxin (lipopolysaccharide)-induced nuclear factor kappa-B (NF-kappaB)-sensitive reporter gene expression, NF-kappaB nuclear translocation, and NF-kappaB/p65 serine phosphorylation. 17-ethynyl-5-androstene-3, 7, 17-triol 33-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 236-239 19907030-17 2010 DHMEQ treatment suppressed the translocation of the NF-kappaB p65 subunit into the nuclei. dehydroxymethylepoxyquinomicin 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 62-65 19907030-20 2010 DHMEQ-mediated regulation of NF-kappaB p65 could be a therapeutic target for the control of endogenous ocular inflammatory diseases. dehydroxymethylepoxyquinomicin 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 39-42 19777559-4 2010 Interestingly, at low concentration of UA, the induction of NF-kappaB p65 translocation into nucleus and the up-regulation of AP-1 and NFATc1 transcript levels were also observed, suggesting that the stimulatory effect of UA on osteoblast differentiation could be mediated through the activation of transcription factors. undecylenic acid 39-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 19777559-4 2010 Interestingly, at low concentration of UA, the induction of NF-kappaB p65 translocation into nucleus and the up-regulation of AP-1 and NFATc1 transcript levels were also observed, suggesting that the stimulatory effect of UA on osteoblast differentiation could be mediated through the activation of transcription factors. undecylenic acid 222-224 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 20360974-9 2010 Analysis of NF-kappaB gene expression showed that the expression of p100, p50 and p65 was induced around 20, 7 and 4 fold, respectively, in both of the intoxication-resistant cell lines following a 2 h treatment with PLxL (0.1+0.1+1 microg/ml). plxl 217-221 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 20007975-8 2010 The mechanism underlying these findings is associated with decreased RelA/p65 phosphorylation (Ser(311)) and translocation of the RelA/p65 subunit of NF-kappaB into the nucleus. Serine 95-98 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-73 20069651-5 2010 Nuclear factor-kappaB p65 was increased in mouse in response to alcohol feeding. Alcohols 64-71 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 22-25 20007975-8 2010 The mechanism underlying these findings is associated with decreased RelA/p65 phosphorylation (Ser(311)) and translocation of the RelA/p65 subunit of NF-kappaB into the nucleus. Serine 95-98 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-77 20007975-8 2010 The mechanism underlying these findings is associated with decreased RelA/p65 phosphorylation (Ser(311)) and translocation of the RelA/p65 subunit of NF-kappaB into the nucleus. Serine 95-98 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 135-138 20007975-9 2010 Furthermore, CS/reactive aldehydes and LPS exposures led to activation and translocation of PKCzeta into the nucleus where it forms a complex with CREB-binding protein (CBP) and acetylated RelA/p65 causing histone phosphorylation and acetylation on promoters of pro-inflammatory genes. Cesium 13-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 189-193 20007975-9 2010 Furthermore, CS/reactive aldehydes and LPS exposures led to activation and translocation of PKCzeta into the nucleus where it forms a complex with CREB-binding protein (CBP) and acetylated RelA/p65 causing histone phosphorylation and acetylation on promoters of pro-inflammatory genes. Cesium 13-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 194-197 20007975-9 2010 Furthermore, CS/reactive aldehydes and LPS exposures led to activation and translocation of PKCzeta into the nucleus where it forms a complex with CREB-binding protein (CBP) and acetylated RelA/p65 causing histone phosphorylation and acetylation on promoters of pro-inflammatory genes. Aldehydes 25-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 189-193 20007975-9 2010 Furthermore, CS/reactive aldehydes and LPS exposures led to activation and translocation of PKCzeta into the nucleus where it forms a complex with CREB-binding protein (CBP) and acetylated RelA/p65 causing histone phosphorylation and acetylation on promoters of pro-inflammatory genes. Aldehydes 25-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 194-197 20007975-10 2010 Taken together, these data suggest that PKCzeta plays an important role in CS/aldehyde- and LPS-induced lung inflammation through acetylation of RelA/p65 and histone modifications via CBP. Cesium 75-77 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 145-149 20007975-10 2010 Taken together, these data suggest that PKCzeta plays an important role in CS/aldehyde- and LPS-induced lung inflammation through acetylation of RelA/p65 and histone modifications via CBP. Cesium 75-77 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 150-153 20007975-10 2010 Taken together, these data suggest that PKCzeta plays an important role in CS/aldehyde- and LPS-induced lung inflammation through acetylation of RelA/p65 and histone modifications via CBP. Aldehydes 78-86 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 145-149 20007975-10 2010 Taken together, these data suggest that PKCzeta plays an important role in CS/aldehyde- and LPS-induced lung inflammation through acetylation of RelA/p65 and histone modifications via CBP. Aldehydes 78-86 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 150-153 19774506-5 2010 Furthermore, madecassic acid suppressed the LPS-induced activation of nuclear factor-kappaB (NF-kappaB), and this was associated with the abrogation of inhibitory kappa B-alpha (IkappaB-alpha) degradation and with the subsequent blocking of p65 protein translocation to the nucleus. madecassic acid 13-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 241-244 19965984-7 2010 IKK2 inhibitor (IMD-0354), which reduces the nuclear translocation of RelA/p65, attenuated CS-mediated neutrophil influx in bronchoalveolar lavage fluid and cytokine (MCP-1 and IP-10) levels in lungs of WT but not in p50-deficient mice. Cesium 91-93 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-74 19965984-7 2010 IKK2 inhibitor (IMD-0354), which reduces the nuclear translocation of RelA/p65, attenuated CS-mediated neutrophil influx in bronchoalveolar lavage fluid and cytokine (MCP-1 and IP-10) levels in lungs of WT but not in p50-deficient mice. Cesium 91-93 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 75-78 19965984-8 2010 Importantly, p50 deficiency resulted in increased phosphorylation (Ser276 and Ser536), acetylation (Lys310), and DNA binding activity of RelA/p65 in mouse lung, associated with increased chromatin remodeling evidenced by specific phosphoacetylation of histone H3 (Ser10/Lys9) and acetylation of H4 (Lys12) in response to CS exposure. Cesium 321-323 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 137-141 19965984-8 2010 Importantly, p50 deficiency resulted in increased phosphorylation (Ser276 and Ser536), acetylation (Lys310), and DNA binding activity of RelA/p65 in mouse lung, associated with increased chromatin remodeling evidenced by specific phosphoacetylation of histone H3 (Ser10/Lys9) and acetylation of H4 (Lys12) in response to CS exposure. Cesium 321-323 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 142-145 19879381-5 2010 The molecular mechanism of bisabolangelone-mediated attenuation in RAW 264.7 cells has a close relationship to suppressing the translocation of nuclear factor-kappaB (NF-kappaB) p65 subunit into the nucleus and the phosphorylation of mitogen-activated protein kinases (MAPKs). bisabolangelone 27-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 178-181 20026303-5 2010 Immunoblotting showed that carabrol suppressed LPS-induced degradation of I-kappaBalpha and decreased nuclear translocation of p65. carabrol 27-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 127-130 20026373-2 2010 The topical application of these phenolics 15min prior to TPA resulted in a significant decrease in the NF-kappaB activation which was measured in terms of p65-DNA binding. Tetradecanoylphorbol Acetate 58-61 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 156-159 20026373-3 2010 Tannic acid was the most potent inhibitor of the TPA-stimulated p65-DNA binding, while chlorogenic acid was the least effective compound. Tannins 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-67 20026373-3 2010 Tannic acid was the most potent inhibitor of the TPA-stimulated p65-DNA binding, while chlorogenic acid was the least effective compound. Tetradecanoylphorbol Acetate 49-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-67 20026373-4 2010 Tannic acid also reduced the most the NF-kappaB p65 subunit translocation from cytosol to the nucleus and enhanced the retention of IkappaBalpha in the cytosol. Tannins 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 48-51 20026373-5 2010 Although protocatechuic acid decreased p65-DNA binding, it did not affect TPA-stimulated degradation of IkappaBalpha. protocatechuic acid 9-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 39-42 21220918-10 2010 Importantly, obvious translocation of ERK and RelA/p65 to nuclei was observed in TGF-beta1-treated podocyte, which was reduced by ERK inhibitor U0126. U 0126 144-149 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 46-50 21220918-10 2010 Importantly, obvious translocation of ERK and RelA/p65 to nuclei was observed in TGF-beta1-treated podocyte, which was reduced by ERK inhibitor U0126. U 0126 144-149 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 19533603-9 2010 Finally, we report that news SERMs, ospemifene and bazedoxifene, exert anti-inflammatory actions by a mechanism involving classical estrogen receptors and by the inhibition of LPS-induced NFkappaB p65 transactivation. Ospemifene 36-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 197-200 19862499-7 2010 In diabetic mice, high-dose avosentan treatment significantly attenuated the glomerulosclerosis index, mesangial matrix accumulation, glomerular accumulation of the matrix proteins collagen IV, and renal expression of genes encoding connective tissue growth factor, vascular endothelial growth factor, transforming growth factor beta and nuclear factor kappaB (p65 subunit). Avosentan 28-37 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 361-364 19533603-9 2010 Finally, we report that news SERMs, ospemifene and bazedoxifene, exert anti-inflammatory actions by a mechanism involving classical estrogen receptors and by the inhibition of LPS-induced NFkappaB p65 transactivation. bazedoxifene 51-63 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 197-200 19609947-7 2009 The phosphorylation of the p65 subunit of NFkappaB at serine 534 is also upregulated in Akt-transformed cells. Serine 54-60 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 27-30 19487987-6 2010 Moreover, the results showed that moscatilin suppressed nuclear translocation of nuclear factor (NF)-kappaB subunits, p65 and p50, and NF-kappaB activity by inhibiting phosphorylation of inhibitor of kappaBalpha. dendrophenol 34-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-121 19819963-7 2009 In addition, CNS resveratrol delivery improves hypothalamic nuclear factor-kappaB inflammatory signaling by reducing acetylated-RelA/p65 and total RelA/p65 protein contents, and inhibitor of nuclear factor-kappaB alpha and IkappaB kinase beta mRNA levels. Resveratrol 17-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 152-155 20025548-3 2009 The effects of Tanshinone II(A) on radiation-induced proinflammatory cytokines were evaluated by real-time polymerase chain reaction; the expression level of nuclear factor (NF-kappabeta) p65 in cytoplasm and nucleus was measured by Western blot. tanshinone 15-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 188-191 20025548-7 2009 Further, Western blotting showed that Tanshinone II(A) could attenuate the nuclear translocation of (NF-kappabeta) p65 submit postirradiation. tanshinone 38-51 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 115-118 19819963-7 2009 In addition, CNS resveratrol delivery improves hypothalamic nuclear factor-kappaB inflammatory signaling by reducing acetylated-RelA/p65 and total RelA/p65 protein contents, and inhibitor of nuclear factor-kappaB alpha and IkappaB kinase beta mRNA levels. Resveratrol 17-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-132 19942803-7 2009 Besides these, CAF, 24-mCAF, beta-SF, as well as eFA and CA, all these chemicals significantly inhibited the NF-kappaB activity as analyzed by measuring translocation of NF-kappaB p65 in LPS-stimulated RAW 264.7 macrophages. beta-sf 29-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 180-183 19819963-7 2009 In addition, CNS resveratrol delivery improves hypothalamic nuclear factor-kappaB inflammatory signaling by reducing acetylated-RelA/p65 and total RelA/p65 protein contents, and inhibitor of nuclear factor-kappaB alpha and IkappaB kinase beta mRNA levels. Resveratrol 17-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 133-136 19819963-7 2009 In addition, CNS resveratrol delivery improves hypothalamic nuclear factor-kappaB inflammatory signaling by reducing acetylated-RelA/p65 and total RelA/p65 protein contents, and inhibitor of nuclear factor-kappaB alpha and IkappaB kinase beta mRNA levels. Resveratrol 17-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 147-151 19942803-7 2009 Besides these, CAF, 24-mCAF, beta-SF, as well as eFA and CA, all these chemicals significantly inhibited the NF-kappaB activity as analyzed by measuring translocation of NF-kappaB p65 in LPS-stimulated RAW 264.7 macrophages. ethyl ferulate 49-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 180-183 19728025-0 2009 Effect of artesunate on inhibiting proliferation and inducing apoptosis of SP2/0 myeloma cells through affecting NFkappaB p65. Artesunate 10-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-125 20054495-8 2009 However, rifampicin slightly inhibited the nuclear translocation of NF-kappaB p65. Rifampin 9-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 78-81 20054495-9 2009 In addition, rifampicin increased physical interaction between pregnane X receptor, a receptor for rifampicin, and NF-kappaB p65, suggesting pregnane X receptor interferes with NF-kappaB binding to DNA. Rifampin 13-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 125-128 20054495-9 2009 In addition, rifampicin increased physical interaction between pregnane X receptor, a receptor for rifampicin, and NF-kappaB p65, suggesting pregnane X receptor interferes with NF-kappaB binding to DNA. Rifampin 99-109 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 125-128 19743406-5 2009 The repression of iNOS but not COX-2 expression may come from the differential effect of inotilone on nuclear factor-kappaB (NFkappaB) and CCAAT/enhancer-binding protein beta Treatment with inotilone resulted in the reduction of LPS-induced nuclear translocation of NFkappaB subunit and the NFkappaB-dependent transcriptional activity by blocking phosphorylation of inhibitor kappaB(IkappaB)alpha and p65 and subsequent degradation of inhibitor kappaBalpha. inotilone 190-199 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 401-404 19728025-11 2009 Additionally, artesunate treatment decreased the level of NFkappaB p65 protein in the nucleus, while increased the level of IkappaBalpha protein in the cytoplasm. Artesunate 14-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 67-70 19706600-3 2009 Here we report that tumor necrosis factor-alpha (TNFalpha) induces RelA polyubiquitination at the lysine 195 residue, and this ubiquitination event is critical for the degradation of RelA and termination of TNFalpha-mediated NF-kappaB activation. Lysine 98-104 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 67-71 19706600-3 2009 Here we report that tumor necrosis factor-alpha (TNFalpha) induces RelA polyubiquitination at the lysine 195 residue, and this ubiquitination event is critical for the degradation of RelA and termination of TNFalpha-mediated NF-kappaB activation. Lysine 98-104 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 183-187 19706600-0 2009 Tumor necrosis factor-alpha induces RelA degradation via ubiquitination at lysine 195 to prevent excessive nuclear factor-kappaB activation. Lysine 75-81 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 36-40 19706600-6 2009 Our finding is the first report that substitution of a key RelA lysine residue with arginine inhibits TNFalpha-induced RelA ubiquitination and enhances TNFalpha-induced NF-kappaB activation. Lysine 64-70 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-63 19706600-6 2009 Our finding is the first report that substitution of a key RelA lysine residue with arginine inhibits TNFalpha-induced RelA ubiquitination and enhances TNFalpha-induced NF-kappaB activation. Lysine 64-70 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-123 19706600-6 2009 Our finding is the first report that substitution of a key RelA lysine residue with arginine inhibits TNFalpha-induced RelA ubiquitination and enhances TNFalpha-induced NF-kappaB activation. Arginine 84-92 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-63 19706600-6 2009 Our finding is the first report that substitution of a key RelA lysine residue with arginine inhibits TNFalpha-induced RelA ubiquitination and enhances TNFalpha-induced NF-kappaB activation. Arginine 84-92 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-123 19762427-5 2009 Immediately after birth, BDNF-independent constitutive activation of NF-kappaB signalling by serine phosphorylation of IkappaBalpha and constitutive dephosphorylation of p65 at serine 536 are required for BDNF-promoted neurite growth. Serine 177-183 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 170-173 19706715-5 2009 RSV infection produced a time-dependent RelA phosphorylation on serine (Ser) residues Ser-276 and Ser-536 in parallel with enhanced reactive oxygen species (ROS) stress. Serine 64-70 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-44 19595779-2 2009 Dimethylfumarate (DMF) is reported to inhibit tumor necrosis factor-alpha-induced nuclear entry of NF-kappaB/p65. Dimethyl Fumarate 0-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-112 19595779-2 2009 Dimethylfumarate (DMF) is reported to inhibit tumor necrosis factor-alpha-induced nuclear entry of NF-kappaB/p65. Dimethyl Fumarate 18-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-112 19595779-6 2009 DMF also inhibited the nuclear entry of NF-kappaB/p65, thus inhibiting B16BL6 cell invasion and metastasis. Dimethyl Fumarate 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 50-53 19762427-4 2009 Shortly before birth, BDNF activates NF-kappaB by an atypical mechanism that involves tyrosine phosphorylation of IkappaBalpha by Src family kinases, and dephosphorylates p65 at serine 536. Serine 178-184 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 171-174 19706715-5 2009 RSV infection produced a time-dependent RelA phosphorylation on serine (Ser) residues Ser-276 and Ser-536 in parallel with enhanced reactive oxygen species (ROS) stress. Serine 72-75 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-44 19706715-5 2009 RSV infection produced a time-dependent RelA phosphorylation on serine (Ser) residues Ser-276 and Ser-536 in parallel with enhanced reactive oxygen species (ROS) stress. Serine 86-89 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-44 19706715-5 2009 RSV infection produced a time-dependent RelA phosphorylation on serine (Ser) residues Ser-276 and Ser-536 in parallel with enhanced reactive oxygen species (ROS) stress. Serine 86-89 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-44 19706715-5 2009 RSV infection produced a time-dependent RelA phosphorylation on serine (Ser) residues Ser-276 and Ser-536 in parallel with enhanced reactive oxygen species (ROS) stress. Reactive Oxygen Species 132-155 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-44 19706715-5 2009 RSV infection produced a time-dependent RelA phosphorylation on serine (Ser) residues Ser-276 and Ser-536 in parallel with enhanced reactive oxygen species (ROS) stress. Reactive Oxygen Species 157-160 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-44 19706715-6 2009 Inhibition of RSV-induced ROS inhibited formation of phospho-Ser-276 RelA without affecting phospho-Ser-536 RelA formation. Reactive Oxygen Species 26-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-73 19706715-6 2009 Inhibition of RSV-induced ROS inhibited formation of phospho-Ser-276 RelA without affecting phospho-Ser-536 RelA formation. Serine 61-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-73 19706715-8 2009 Inhibition of MSK1 using H89 and small interfering RNA knockdown both reduced RSV-induced phospho-Ser-276 RelA formation and expression of a subset of NF-kappaB-dependent genes. Serine 98-101 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 106-110 19722705-5 2009 Furthermore, troxerutin inhibited the upregulation of the expression of NF-kappaB p65, iNOS, and COX-2 induced by D-gal. Galactose 114-119 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 19474282-11 2009 alpha-LA also attenuated the cisplatin-induced increases in the phosphorylation and nuclear translocation of NF- kappaB p65 subunits in kidney tissue. Cisplatin 29-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 120-123 20137697-7 2009 The expression of NF-kappaB p65 and TNF-alpha [(266 +/- 35) pg/ml] in mice with DSS-induced colitis was significantly reduced after treatment with NF-kappaB p65 siRNA (P < 0.05) in comparisons with the scrambled siRNA [(412 +/- 51) pg/ml] and DSS group pg/ml [(449 +/- 44) pg/ml]. dss 80-83 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 28-31 20137697-7 2009 The expression of NF-kappaB p65 and TNF-alpha [(266 +/- 35) pg/ml] in mice with DSS-induced colitis was significantly reduced after treatment with NF-kappaB p65 siRNA (P < 0.05) in comparisons with the scrambled siRNA [(412 +/- 51) pg/ml] and DSS group pg/ml [(449 +/- 44) pg/ml]. dss 80-83 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 157-160 20137697-7 2009 The expression of NF-kappaB p65 and TNF-alpha [(266 +/- 35) pg/ml] in mice with DSS-induced colitis was significantly reduced after treatment with NF-kappaB p65 siRNA (P < 0.05) in comparisons with the scrambled siRNA [(412 +/- 51) pg/ml] and DSS group pg/ml [(449 +/- 44) pg/ml]. dss 246-249 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 28-31 20137697-7 2009 The expression of NF-kappaB p65 and TNF-alpha [(266 +/- 35) pg/ml] in mice with DSS-induced colitis was significantly reduced after treatment with NF-kappaB p65 siRNA (P < 0.05) in comparisons with the scrambled siRNA [(412 +/- 51) pg/ml] and DSS group pg/ml [(449 +/- 44) pg/ml]. dss 246-249 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 157-160 19168128-0 2009 Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-kappaB p65 phosphorylation at serine 276. licochalcone 0-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 98-101 19553566-5 2009 Our data also showed that roscovitine attenuated LPS-induced phosphorylation of IkappaB kinase beta (IKKbeta), IkappaB, and p65 but enhanced the phosphorylation of ERK, p38, and c-Jun NH(2)-terminal kinase (JNK). Roscovitine 26-37 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 124-127 19483316-6 2009 Consistent with these findings, pretreatment with fraxinellone significantly suppressed the LPS-stimulated phosphorylation of inhibitory kappa B-alpha (IkappaB-alpha) and the subsequent translocation of p65 to the nucleus. fraxinellone 50-62 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 203-206 19457134-4 2009 Treatment with p38 inhibitor, SB239063, prevented downstream phosphorylation of IkappaB alpha and p65 translocation to the nucleus in the ventral midbrain. SB 239063 30-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 98-101 19587437-7 2009 NF-kappaB-P65 DNA binding activity at PT group was remarkably higher than that in the NP, LP and PP groups (P<0.05). leucylproline 90-92 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 10-13 19193728-7 2009 EMSA and ChIP assays demonstrated increased p65/p50 binding to a NF-kappaB binding site at -1734 in the AGT gene promoter upon high glucose stimulation, and the binding was disrupted by 1,25(OH)(2)D(3) treatment. Glucose 132-139 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 44-47 19671685-6 2009 The transcription factor pattern and the motile phenotype of metastatic 1833 cells were influenced by p65-lysine acetylation and HDAC-dependent epigenetic mechanisms, which positively regulated basal NF-kappaB and HIF-1 activities. Lysine 106-112 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-105 19279313-10 2009 Importantly, resveratrol-treated animals showed significant decline of retinal 8-OHdG generation and nuclear NF-kappaB P65 translocation, both of which were upregulated after EIU induction. Resveratrol 13-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-122 19349371-2 2009 After analyzing NF-kappaB activation during increasing times of ischemia in murine I/R, we observed that the nuclear translocation of p65 paralleled Src and IkappaB tyrosine phosphorylation, which peaked after 60 minutes of ischemia. Tyrosine 165-173 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 134-137 19349371-8 2009 In contrast, indiscriminate hepatic GSH depletion by buthionine-sulfoximine before I/R potentiated oxidative stress and decreased both nuclear p65 and Mn-SOD expression levels, increasing TNF/IL-1beta up-regulation and I/R-induced liver damage. Glutathione 36-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 143-146 19349371-8 2009 In contrast, indiscriminate hepatic GSH depletion by buthionine-sulfoximine before I/R potentiated oxidative stress and decreased both nuclear p65 and Mn-SOD expression levels, increasing TNF/IL-1beta up-regulation and I/R-induced liver damage. Buthionine Sulfoximine 53-75 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 143-146 19168128-5 2009 Strikingly, Licochalcone A significantly inhibited LPS-induced NF-kappaB transcriptional activation; however, it had no effect on not only the phosphorylation and degradation of IkappaBalpha but also nuclear translocation and DNA binding activity of NF-kappaB p65. licochalcone 12-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 260-263 19168128-6 2009 Interestingly, Licochalcone A markedly inhibited the phosphorylation of p65 at serine 276. licochalcone 15-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 19168128-6 2009 Interestingly, Licochalcone A markedly inhibited the phosphorylation of p65 at serine 276. Serine 79-85 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 19168128-0 2009 Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-kappaB p65 phosphorylation at serine 276. Serine 121-127 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 98-101 19255242-6 2009 Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes. Vorinostat 48-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 98-101 19255242-6 2009 Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes. Vorinostat 48-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-106 19255242-6 2009 Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes. Vorinostat 48-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 178-181 19255242-6 2009 Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes. Vorinostat 48-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 182-186 19255242-6 2009 Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes. Lysine 110-116 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 98-101 19377466-6 2009 We show that WIP1 is a direct phosphatase of Ser 536 of the p65 subunit of NF-kappaB. Serine 45-48 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 60-63 19377466-7 2009 Phosphorylation of Ser 536 is known to be essential for the transactivation function of p65, as it is required for recruitment of the transcriptional co-activator p300. Serine 19-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 19170127-9 2009 Concomitant administration of Dex, a known NF-kappaB inhibitor, resulted in significantly down-regulated IL-1 beta-induced NF-kappaB/p65 activity, as well as reduced expression of chemokine receptors and IL-17F in mouse prostate tissue. Dexamethasone 30-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 133-136 19255242-6 2009 Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes. Lysine 110-116 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-106 19255242-6 2009 Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes. Lysine 110-116 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 178-181 19255242-6 2009 Induction of DRG mGlu2 receptors in response to SAHA was associated with increased acetylation of p65/RelA on lysine 310, a process that enhances the transcriptional activity of p65/RelA at nuclear factor-kappaB-regulated genes. Lysine 110-116 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 182-186 19249228-7 2009 Additionally, TARL prominently decreased LPS-induced activation of IKKalpha and phosphorylation of p65 on serine 276, but had little impact on the phosphorylation and degradation of IkappaBalpha. Serine 106-112 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-102 19201922-12 2009 Similarly, andrographolide blocked p65 nuclear translocation and DNA-binding activity in the nuclear extracts from lung tissues of OVA-challenged mice. andrographolide 11-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 35-38 19298756-8 2009 Pre-administration of quetiapine significantly alleviated neuronal injury, while inhibiting neurogenesis and down-regulating NF-kappaB p65/p50 expression. Quetiapine Fumarate 22-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 135-138 19194838-5 2009 Lucidone also reduced the translocation of NF-kappaB induced by LPS, which is associated with the prevention of the degradation of I-kappaB, and subsequently decreased p65/p50 protein levels in the nucleus. lucidone 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 168-171 19174150-0 2009 1,5-Anhydro-D-fructose attenuates lipopolysaccharide-induced cytokine release via suppression of NF-kappaB p65 phosphorylation. 1,5-anhydrofructose 0-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-110 19174150-6 2009 Furthermore, pretreatment with 1,5-AF (500 microg/ml) attenuated cytokine release, and 1,5-AF directly inhibited the nuclear translocalization of the NF-kappaB p65 subunit in LPS-stimulated murine macrophage-like RAW264.7 cells. 1,5-anhydrofructose 31-37 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 160-163 19174150-6 2009 Furthermore, pretreatment with 1,5-AF (500 microg/ml) attenuated cytokine release, and 1,5-AF directly inhibited the nuclear translocalization of the NF-kappaB p65 subunit in LPS-stimulated murine macrophage-like RAW264.7 cells. 1,5-anhydrofructose 87-93 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 160-163 19298756-0 2009 Quetiapine regulates neurogenesis in ischemic mice by inhibiting NF-kappaB p65/p50 expression. Quetiapine Fumarate 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 75-78 19060926-3 2009 AG14361, a potent PARP-1 inhibitor, was used in two breast cancer cell lines expressing different levels of constitutively activated NF-kappaB, as well as mouse embryonic fibroblasts (MEFs) proficient or deficient for PARP-1 or NF-kappaB p65. 1-(4-dimethylaminomethylphenyl)-8,9-dihydro-7H-2,7,9a-benzo(cd)azulen-6-one 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 238-241 19103154-9 2009 Then, we found that (-)-DHMEQ lowered the nuclear amount of p65. dehydroxymethylepoxyquinomicin 20-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 60-63 19103154-10 2009 Thus, inhibition of the C/EBPbeta activity by (-)-DHMEQ would be due to a reduction in the amount of nuclear p65, which has a co-activator activity for C/EBPbeta that is essential for the HDC induction. dehydroxymethylepoxyquinomicin 46-55 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-112 19053978-14 2009 Activation of nuclear factor-kappaB is critical to LIX expression in MLE-12 cells, and acute ethanol treatment interferes with early activation of this pathway as evidenced by impairing phosphorylation of p65 (RelA). Ethanol 93-100 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 205-208 19053978-14 2009 Activation of nuclear factor-kappaB is critical to LIX expression in MLE-12 cells, and acute ethanol treatment interferes with early activation of this pathway as evidenced by impairing phosphorylation of p65 (RelA). Ethanol 93-100 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 210-214 19060926-9 2009 Consistent with this, AG14361 sensitized p65(+/+) but not p65(-/-) MEFs to IR. 1-(4-dimethylaminomethylphenyl)-8,9-dihydro-7H-2,7,9a-benzo(cd)azulen-6-one 22-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 41-44 19027004-2 2009 In this study, we investigated the time course changes of NF-kappaB (Nuclear factor kappa B) p65 protein and apoptosis in the substantia nigra after MPTP treatment in mice. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 149-153 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 93-96 19139021-8 2009 Silibinin decreased the phosphorylation of p65NF-kappaB (ser276, 38%; P < 0.01) and STAT-3 (ser727, 16%; P < 0.01) in tumor cells and decreased the lung macrophage population. Silybin 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 43-55 19027004-7 2009 On the other hand, a significant increase of NF-kappaB p65 immunoreactivity was observed mainly in glial cells of the substantia nigra from 5 h to 3 days after MPTP treatment. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 160-164 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 19054675-4 2009 Daily treatment (30 days) of 1 month old mdx mice with the inhibitor ursodeoxycholic acid (UDCA) reduced costal diaphragm nuclear p65 activation by 40% and increased WBT by 21%. Ursodeoxycholic Acid 69-89 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 130-133 19135889-4 2009 SIRT6 interacts with the NF-kappaB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-kappaB target gene promoters. Lysine 76-82 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 35-39 19131703-4 2008 Immunoblotting analysis showed that surfactin strongly blocked the phosphorylation of IKK and IkBa and the nuclear translocation of NF-kappaB (p65). surfactin peptide 36-45 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 143-146 19131801-11 2009 PTX decreased cytoplasmic IKK, IkappaB-alpha phosphorylation, and nuclear NF-kappaB p65 translocation to sham levels (p < 0.05 vs. NS). Pentoxifylline 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 18838070-7 2008 LPS-induced p65 phosphorylation, which is mediated by extracellular signal-regulated kinase (ERK) and Akt pathways, was attenuated by withaferin A treatment. withaferin A 134-146 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 12-15 18816057-5 2008 Moreover, significant increases of phosphorylated AKT, NF-kappaB (p65), and ERK1/2 proteins were detected in liver from the cholesterol/taurine group as compared to the cholesterol group. Cholesterol 124-135 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 18835347-7 2008 SA inhibited NF-kappaB activation by prevention of the degradation of inhibitory factor-kappaB and p65 level in nuclear fractions induced by LPS. sa 0-2 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-102 18959816-4 2008 Protein levels of NF-kappaB p65 and relB were clearly enhanced during retinoic acid-induced differentiation. Tretinoin 70-83 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 28-31 18798274-5 2008 Apoptotic cells were increased after transfection of NF-kappaB p65 siRNA compared with control siRNA in the treatment with paclitaxel. Paclitaxel 123-133 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 63-66 18798274-8 2008 Finally, mice treated by intraperitoneal administration of NF-kappaB p65 siRNA and paclitaxel survived for a significantly longer time than mice treated by intraperitoneal administration of paclitaxel alone (p = 0.0002). Paclitaxel 190-200 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-72 18683823-6 2008 Treatment with 6-shogaol resulted in the reduction of LPS-induced nuclear translocation of nuclear factor-kappaB (NF kappaB) subunit and the dependent transcriptional activity of NF kappaB by blocking phosphorylation of inhibitor kappaB (I kappaB)alpha and p65 and subsequent degradation of I kappaB alpha. shogaol 15-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 257-260 18755736-6 2008 Examination of the expression of the NF-kappaB subunits, p50 and p65, in Akt1 wild-type testes following MEHP exposure revealed a twofold increase in p50 mRNA at 6 h. Interestingly, in Akt1-deficient testes, basal expression of both the p50 and p65 subunits was elevated 1.6- and 4-fold, respectively. mono-(2-ethylhexyl)phthalate 105-109 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 65-68 18397230-6 2008 In vitro studies disclosed that the administration of ATRA reduced (i) the production of TGF-beta1, IL-6 and collagen from HSCs, (ii) TGF-beta-dependent transdifferentiation of the cells and IL-6-dependent cell proliferation and (iii) the activities of nuclear factor-kappaB p65 and p38mitogen-activated protein kinase, which stimulate the production of TGF-beta1 and IL-6, which could be the mechanism underlying the preventive effect of ATRA on liver fibrosis. Tretinoin 54-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 275-278 18816057-5 2008 Moreover, significant increases of phosphorylated AKT, NF-kappaB (p65), and ERK1/2 proteins were detected in liver from the cholesterol/taurine group as compared to the cholesterol group. Taurine 136-143 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 18691416-11 2008 15d-PGJ2 modulated the adhesion process by inhibiting the TNFalpha induced IKK-NF-kappaB pathway as evident from EMSA, NF-kappaB reporter and p65 mediated transcriptional activity results in bEND.3 cells. 15-deoxy-delta(12,14)-prostaglandin J2 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 142-145 18341569-0 2008 Anti-inflammatory and immune-regulatory mechanisms prevent contact hypersensitivity to Arnica montana L. Sesquiterpene lactones (SL), secondary plant metabolites from flowerheads of Arnica, exert anti-inflammatory effects mainly by preventing nuclear factor (NF)-kappaB activation because of alkylation of the p65 subunit. sesquiterpene lactones 105-127 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 310-313 18809715-6 2008 Hyperglycemia-induced epigenetic changes and increased p65 expression are prevented by reducing mitochondrial superoxide production or superoxide-induced alpha-oxoaldehydes. Superoxides 110-120 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 18809715-6 2008 Hyperglycemia-induced epigenetic changes and increased p65 expression are prevented by reducing mitochondrial superoxide production or superoxide-induced alpha-oxoaldehydes. Superoxides 135-145 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 18809715-6 2008 Hyperglycemia-induced epigenetic changes and increased p65 expression are prevented by reducing mitochondrial superoxide production or superoxide-induced alpha-oxoaldehydes. alpha-oxoaldehydes 154-172 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 18656926-4 2008 Treatment with pterostilbene resulted in the reduction of LPS-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunit and the dependent transcriptional activity of NFkappaB by blocking phosphorylation of inhibitor kappaB (IkappaB)alpha and p65 and subsequent degradation of IkappaB alpha. pterostilbene 15-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 262-265 18922932-10 2008 Analysis of tumors from delphinidin-treated mice showed significant decrease in the expression of NF-kappaB/p65, Bcl2, Ki67, and PCNA. delphinidin 24-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 108-111 18621044-8 2008 Moreover, increased phosphorylated p65 (NF-kappaB) protein was observed in brain of NZB/W F1 mice treated with cystamine as compared to control group. Cystamine 111-120 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 35-38 18362169-4 2008 Although inducible RelA binding occurs with similar kinetics on all NF-kappaB-dependent genes, serine 276 (Ser(276))-phosphorylated RelA binding is seen primarily on a subset of genes that are rapidly induced by tumor necrosis factor (TNF), including Gro-beta, interleukin-8 (IL-8), and IkappaBalpha. Serine 95-101 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 132-136 18508047-6 2008 We further provided evidence that p50, but not p65 subunit of NF-kappaB, was involved in GADD45alpha induction and the subsequent MAPKK/MAPK/AP-1 activation under arsenite exposure, while functional NF-kappaB induced by arsenite stimulation consisted of p65 but not of p50 subunit. arsenite 163-171 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 254-257 18474228-10 2008 Ceftiofur also inhibited p65-NF-kappaB translocation into the nucleus. ceftiofur 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 25-38 18425423-0 2008 Chemopreventive activity of lantadenes on two-stage carcinogenesis model in Swiss albino mice: AP-1 (c-jun), NFkappaB (p65) and P53 expression by ELISA and immunohistochemical localization. lantadenes 28-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 119-122 18425423-7 2008 Significant increase in the protein levels of c-jun, p65, and p53 by ELISA were observed in DMBA/TPA treated mice tumors whereas less expression was observed in LA and LAM treated tumors. 9,10-Dimethyl-1,2-benzanthracene 92-96 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 18425423-7 2008 Significant increase in the protein levels of c-jun, p65, and p53 by ELISA were observed in DMBA/TPA treated mice tumors whereas less expression was observed in LA and LAM treated tumors. Tetradecanoylphorbol Acetate 97-100 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 18239189-9 2008 Taken together, these data suggest that IKK alpha plays a key role in CS-induced pro-inflammatory gene transcription through phospho-acetylation of both RelA/p65 and histone H3. Cesium 70-72 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 153-157 18239189-9 2008 Taken together, these data suggest that IKK alpha plays a key role in CS-induced pro-inflammatory gene transcription through phospho-acetylation of both RelA/p65 and histone H3. Cesium 70-72 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 158-161 18536734-5 2008 MPO activity, pro-inflammatory cytokines and COX-2 levels, NF-kappaB p65 nuclear translocation and inhibitory protein of nuclear factor-kappaB-alpha degradation levels were significantly increased in DSS-induced colitis tissues. dss 200-203 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-72 18362169-4 2008 Although inducible RelA binding occurs with similar kinetics on all NF-kappaB-dependent genes, serine 276 (Ser(276))-phosphorylated RelA binding is seen primarily on a subset of genes that are rapidly induced by tumor necrosis factor (TNF), including Gro-beta, interleukin-8 (IL-8), and IkappaBalpha. Serine 107-110 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 132-136 18362169-5 2008 Previous work has shown that TNF-inducible RelA Ser(276) phosphorylation is controlled by a reactive oxygen species (ROS)-protein kinase A signaling pathway. Serine 48-51 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 43-47 18362169-5 2008 Previous work has shown that TNF-inducible RelA Ser(276) phosphorylation is controlled by a reactive oxygen species (ROS)-protein kinase A signaling pathway. Reactive Oxygen Species 92-115 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 43-47 18362169-5 2008 Previous work has shown that TNF-inducible RelA Ser(276) phosphorylation is controlled by a reactive oxygen species (ROS)-protein kinase A signaling pathway. Reactive Oxygen Species 117-120 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 43-47 18362169-6 2008 To further understand the role of phospho-Ser(276) RelA in target gene expression, we inhibited its formation by ROS scavengers and antioxidants, treatments that disrupt phospho-Ser(276) formation but not the translocation and DNA binding of nonphosphorylated RelA. Serine 42-45 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-55 18362169-6 2008 To further understand the role of phospho-Ser(276) RelA in target gene expression, we inhibited its formation by ROS scavengers and antioxidants, treatments that disrupt phospho-Ser(276) formation but not the translocation and DNA binding of nonphosphorylated RelA. Reactive Oxygen Species 113-116 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-55 18362169-7 2008 Here we find that phospho-Ser(276) RelA is required only for activation of IL-8 and Gro-beta, with IkappaBalpha being unaffected. Serine 26-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 35-39 18551458-6 2008 Both stilbenes inhibited the activation of NF-kappaB by blocking the translocation of p65 to the nucleus and increasing the retention of IkappaBa in the cytosol. Stilbenes 5-14 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 86-89 18362169-9 2008 In addition, we observe that phospho-Ser(276) RelA binds the positive transcription elongation factor b (P-TEFb), a complex containing the cyclin-dependent kinase 9 (CDK-9) and cyclin T1 subunits. Serine 37-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 46-50 18362169-10 2008 Inhibition of P-TEFb activity by short interfering RNA (siRNA)-mediated knockdown shows that the phospho-Ser(276) RelA-P-TEFb complex is required for IL-8 and Gro-beta gene activation but not for IkappaBalpha gene activation. Serine 105-108 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-118 18362169-12 2008 One is mediated by phospho-Ser(276) RelA formation and chromatin targeting of P-TEFb controlling polymerase II (Pol II) recruitment and carboxy-terminal domain phosphorylation on the IL-8 and Gro-beta genes. Serine 27-30 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 36-40 18362169-13 2008 The second involves a phospho-Ser(276) RelA-independent activation of genes preloaded with Pol II, exemplified by the IkappaBalpha gene. Serine 30-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 39-43 17977619-4 2008 In the cells treated with H(2)O(2), significant increases in the immunoreactivities of DJ-1 and nuclear factor-kappaB (NF-kappaB) subunits (p65 and p50) were observed in the nuclear fraction. Hydrogen Peroxide 26-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 140-143 18423597-4 2008 Further, IkappaBalpha phosphorylation and NF-kappaB p65 translocation to the nucleus appeared rapidly when embryoid bodies exposed to icariin, and the expression of IkappaBalpha or NF-kappaB p65 in cytoplasm was decreased concomitantly. icariin 134-141 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 52-55 18263801-5 2008 MEASUREMENTS AND MAIN RESULTS: After administration of Dox, expression of the CA-IKKbeta transgene induced the nuclear translocation of RelA in airway epithelium. Doxycycline 55-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-140 18279797-5 2008 Furthermore, asiatic acid inhibited the NF-kappaB activation induced by LPS, and this was associated with the abrogation of I kappa B-alpha degradation and with subsequent decreases in nuclear p65 and p50 protein levels. asiatic acid 13-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 193-196 18328451-9 2008 The phosphorylation of NF-kappaB (p65) could be a possible mechanism involving anti-apoptotic effects of cystamine in liver from NZB/W F1 mice. Cystamine 105-114 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 34-37 18250470-7 2008 Mice lacking colonic RelA were sensitive to dextran sodium sulfate-induced colitis. dextran sodium sulfate 44-66 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 21-25 18083899-11 2008 Inhibition of p38 MAP kinase (SB-202190) blocked both NF-kappaB p65 phosphorylation and NF-kappaB nuclear translocation. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 30-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-67 18060707-5 2008 Furthermore, SDEE suppressed the LPS-induced p65 expression of NF-kappa B, which was associated with the inhibition of I kappa B-alpha degradation. sdee 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 45-48 18060707-7 2008 These results suggest among possibilities of anti-inflammation that SDEE inhibits the production of NO and PGE2 by the down-regulation of iNOS and COX-2 gene expression via the suppression of NF-kappaB (p65) activation. sdee 68-72 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 203-206 17889625-9 2008 DHA pretreatment in vivo decreased TNFalpha secretion and p65 activity, and increased PPARalpha and gamma expression and function. Docosahexaenoic Acids 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 58-61 18025230-7 2007 HO-1 inhibits NF-kappaB (i.e., RelA) phosphorylation at Ser(276), a phosphoacceptor that is critical to sustain TNF-driven NF-kappaB activity in EC. Serine 56-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-35 18652567-5 2008 The study also reveals that 13-cis-retinoic acid treatment could alter the production and expression of proinflammatory cytokines and could inhibit the activation and nuclear translocation of p65, p50, and c-Rel subunits of nuclear factor-kappaB, and other transcription factors such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response element-binding protein in B16F-10 melanoma cells. Isotretinoin 28-48 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 192-195 18652567-5 2008 The study also reveals that 13-cis-retinoic acid treatment could alter the production and expression of proinflammatory cytokines and could inhibit the activation and nuclear translocation of p65, p50, and c-Rel subunits of nuclear factor-kappaB, and other transcription factors such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response element-binding protein in B16F-10 melanoma cells. Cyclic AMP 332-362 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 192-195 18025192-7 2007 Exogenous 15-deoxy-Delta(12,14)-prostaglandin J2, a natural ligand for PPAR-gamma, also induced redistribution of p65 with decreased TNF-alpha secretion after LPS challenge. 15-deoxy-delta(12,14)-prostaglandin J2 10-48 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-117 19066126-9 2008 Furthermore, 13-cis-retinoic acid treatment could inhibit the activation and nuclear translocation of p65, p50, c-Rel subunits of nuclear factor-KB, and other transcription factors such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response element-binding protein in B16F-10 melanoma cells. Isotretinoin 13-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-105 19066126-9 2008 Furthermore, 13-cis-retinoic acid treatment could inhibit the activation and nuclear translocation of p65, p50, c-Rel subunits of nuclear factor-KB, and other transcription factors such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response element-binding protein in B16F-10 melanoma cells. Cyclic AMP 234-264 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-105 17962218-4 2007 Pre-treatment with 5-OH-HxMF resulted in the reduction of TPA-induced nuclear translocation of nuclear factor-kappaB (NF-kappaB) subunit and DNA binding by blocking phosphorylation of inhibitor kappaB (IkappaB) alpha and p65 and subsequent degradation of IkappaBalpha. 5-oh 19-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 221-224 17962218-4 2007 Pre-treatment with 5-OH-HxMF resulted in the reduction of TPA-induced nuclear translocation of nuclear factor-kappaB (NF-kappaB) subunit and DNA binding by blocking phosphorylation of inhibitor kappaB (IkappaB) alpha and p65 and subsequent degradation of IkappaBalpha. hxmf 24-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 221-224 17962218-4 2007 Pre-treatment with 5-OH-HxMF resulted in the reduction of TPA-induced nuclear translocation of nuclear factor-kappaB (NF-kappaB) subunit and DNA binding by blocking phosphorylation of inhibitor kappaB (IkappaB) alpha and p65 and subsequent degradation of IkappaBalpha. Tetradecanoylphorbol Acetate 58-61 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 221-224 18025230-0 2007 Heme oxygenase-1 inhibits the expression of adhesion molecules associated with endothelial cell activation via inhibition of NF-kappaB RelA phosphorylation at serine 276. Serine 159-165 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 135-139 18025230-9 2007 In conclusion, we demonstrate a novel mechanism via which HO-1 down-modulates the proinflammatory phenotype of activated EC, i.e., the inhibition of RelA phosphorylation at Ser(276). Serine 173-176 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 149-153 18048936-7 2007 We show that in B. anthracis the relA gene is responsible for the synthesis of (p)ppGpp and the stringent down-regulation of stable RNA synthesis upon starvation for the essential amino acids isoleucine, leucine and valine. Amino Acids, Essential 170-191 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-37 18048936-7 2007 We show that in B. anthracis the relA gene is responsible for the synthesis of (p)ppGpp and the stringent down-regulation of stable RNA synthesis upon starvation for the essential amino acids isoleucine, leucine and valine. Leucine 195-202 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-37 18048936-7 2007 We show that in B. anthracis the relA gene is responsible for the synthesis of (p)ppGpp and the stringent down-regulation of stable RNA synthesis upon starvation for the essential amino acids isoleucine, leucine and valine. Valine 216-222 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-37 17690092-3 2007 With moderate GSH depletion (approximately 50%), the down-regulation is IkappaB kinase (IKK)-independent and likely acts on NF-kappaB transcriptional activity because TNF-induced IKK activation, IkappaBalpha phosphorylation and degradation, NF-kappaB nuclear translocation, NF-kappaB DNA binding in vitro, and NF-kappaB subunit RelA(p65) recruitment to kappaB sites of target gene promoters all appear unaltered. Glutathione 14-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 328-332 17947640-2 2007 In this study, we observed that Lf protein augmented p65 phosphorylation at the Ser(536), but not the Ser(276) residue, and stimulated the translocation of p65 into the nucleus. Serine 80-83 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 17982090-6 2007 Rectal administration of the NF-kappaB p65 antisense oligonucleotide reduced but did not abrogate inflammation and fibrosis completely. Oligonucleotides 53-68 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 39-42 17690092-3 2007 With moderate GSH depletion (approximately 50%), the down-regulation is IkappaB kinase (IKK)-independent and likely acts on NF-kappaB transcriptional activity because TNF-induced IKK activation, IkappaBalpha phosphorylation and degradation, NF-kappaB nuclear translocation, NF-kappaB DNA binding in vitro, and NF-kappaB subunit RelA(p65) recruitment to kappaB sites of target gene promoters all appear unaltered. Glutathione 14-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 333-336 17556716-14 2007 Western blot analysis of whole lung lysates revealed that TDZD-8 markedly attenuated the phosphorylation of the nuclear factor-kappaB subunit p65 from ovalbumin-challenged mice. 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione 58-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 142-145 17786049-6 2007 Functional characterization of COMMD1 in NFkappaB signaling and ATP7B-dependent biliary copper excretion suggested that COMMD1 also has a role in regulating the protein degradation of RelA (p65) and ATP7B. Copper 88-94 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 184-188 17786049-6 2007 Functional characterization of COMMD1 in NFkappaB signaling and ATP7B-dependent biliary copper excretion suggested that COMMD1 also has a role in regulating the protein degradation of RelA (p65) and ATP7B. Copper 88-94 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 190-193 17761639-11 2007 The study reveals that beta-carotene treatment could alter proinflammatory cytokine production and could inhibit the activation and nuclear translocation of p65, p50, c-Rel subunits of nuclear factor-kappa B, and other transcription factors such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response element-binding protein in B16F-10 melanoma cells. Cyclic AMP 294-324 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 157-160 17724226-10 2007 In vitro, glucose-induced nuclear translocation of NF-kappaB p65 and upregulation of ICAM-1 and MCP-1 were significantly suppressed by application of the ARB. Glucose 10-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 61-64 17761639-11 2007 The study reveals that beta-carotene treatment could alter proinflammatory cytokine production and could inhibit the activation and nuclear translocation of p65, p50, c-Rel subunits of nuclear factor-kappa B, and other transcription factors such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response element-binding protein in B16F-10 melanoma cells. beta Carotene 23-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 157-160 17537731-5 2007 The mutation of IKKalpha putative nuclear localization sequence, which prevents its nuclear translocation, or of crucial serines in the IKKalpha activation loop completely inhibits p65 binding on icam-1 and mcp-1 promoters and rather enhances p65 binding on the ikappabalpha promoter. Serine 121-128 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 181-184 17631635-11 2007 Additionally, the substitution of T352 with a proline inhibited p65 cleavage. C.I. DIRECT BLACK 22 34-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-67 17631635-11 2007 Additionally, the substitution of T352 with a proline inhibited p65 cleavage. Proline 46-53 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-67 17641041-6 2007 A high rate of NF-kappaB/p65 degradation in LNK cells correlates with Pro1 activity, since treatment with the proteasome inhibitor MG132 increased levels of NF-kappaB/p65 protein and decreased Pro1 activity. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 131-136 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 25-28 17641041-6 2007 A high rate of NF-kappaB/p65 degradation in LNK cells correlates with Pro1 activity, since treatment with the proteasome inhibitor MG132 increased levels of NF-kappaB/p65 protein and decreased Pro1 activity. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 131-136 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 167-170 17548797-7 2007 The study reveals that amentoflavone treatment could alter proinflammatory cytokine production and could inhibit the activation and nuclear translocation of p65, p50, c-Rel subunits of nuclear factor-kappaB, and other transcription factors such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response element-binding protein in B16F-10 melanoma cells. Cyclic AMP 293-323 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 157-160 17372274-6 2007 Pre-treatment with humulone attenuated TPA-induced phosphorylation of p65 and nuclear translocation of NF-kappaB subunit proteins. humulon 19-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 17372274-6 2007 Pre-treatment with humulone attenuated TPA-induced phosphorylation of p65 and nuclear translocation of NF-kappaB subunit proteins. Tetradecanoylphorbol Acetate 39-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 17507908-6 2007 This was suppressed by 1,25(OH)2D3, but this decrease was reversed by overexpression of p65. Calcitriol 23-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 17507908-7 2007 1,25(OH)2D3 was found to stabilize IkappaBalpha leading to an inhibition of p65 translocation to the nucleus and subsequent reduction of NF-kappaB binding. Calcitriol 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 76-79 17548797-7 2007 The study reveals that amentoflavone treatment could alter proinflammatory cytokine production and could inhibit the activation and nuclear translocation of p65, p50, c-Rel subunits of nuclear factor-kappaB, and other transcription factors such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response element-binding protein in B16F-10 melanoma cells. amentoflavone 23-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 157-160 17404063-6 2007 EGCG also suppressed TPA-induced phosphorylation and subsequent degradation of IkappaBalpha, and prevented nuclear translocation of p65. epigallocatechin gallate 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 132-135 17409458-7 2007 Concomitantly, phospho-signal transducers and activators of transcription 3 (Tyr(705)) and phospho-p65(Ser(536)) were also decreased by silibinin, which are potential up-stream regulators of iNOS and COX-2. Serine 103-106 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-102 17409458-7 2007 Concomitantly, phospho-signal transducers and activators of transcription 3 (Tyr(705)) and phospho-p65(Ser(536)) were also decreased by silibinin, which are potential up-stream regulators of iNOS and COX-2. Silybin 136-145 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-102 17409458-10 2007 Further analysis showed that silibinin inhibited UVB-caused phosphorylation and nuclear translocation of STAT3 and p65, as well as nuclear factor kappaB (NF-kappaB) DNA binding activity. Silybin 29-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 115-118 17202332-6 2007 Moreover, guanosine abrogated IFN-gamma-induced phosphorylation on Ser(727) and translocation of STAT-1alpha to the nucleus as well as TNF-alpha-/Abeta-induced IkappaBalpha and NF-kappaB p65/RelA subunit phosphorylation, thus inhibiting NF-kappaB-induced nuclear translocation. Guanosine 10-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 187-190 17202332-6 2007 Moreover, guanosine abrogated IFN-gamma-induced phosphorylation on Ser(727) and translocation of STAT-1alpha to the nucleus as well as TNF-alpha-/Abeta-induced IkappaBalpha and NF-kappaB p65/RelA subunit phosphorylation, thus inhibiting NF-kappaB-induced nuclear translocation. Guanosine 10-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 191-195 17449583-6 2007 Most important for understanding the mechanism involved, chromatin immunoprecipitation analysis revealed inhibitory effects of quercetin on phospho-RelA recruitment to the IP-10 and MIP-2 gene promoters. Quercetin 127-136 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 148-152 17258194-5 2007 The evaluation of nuclear factor-kappaB (NF-kappaB) pathway revealed that topical treatment with alpha-amyrin is able to prevent IkappaB alpha degradation, p65/RelA phosphorylation and NF-kappaB activation. beta-amyrin 97-109 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 156-159 17258194-5 2007 The evaluation of nuclear factor-kappaB (NF-kappaB) pathway revealed that topical treatment with alpha-amyrin is able to prevent IkappaB alpha degradation, p65/RelA phosphorylation and NF-kappaB activation. beta-amyrin 97-109 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 160-164 17070014-8 2007 By using Ser to Ala mutants in p65 and c-Rel transactivation domains, PKCzeta and NIK activities seem to be dependent of a restricted set of Ser in both proteins. Serine 9-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-34 17070014-8 2007 By using Ser to Ala mutants in p65 and c-Rel transactivation domains, PKCzeta and NIK activities seem to be dependent of a restricted set of Ser in both proteins. Alanine 16-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-34 17070014-8 2007 By using Ser to Ala mutants in p65 and c-Rel transactivation domains, PKCzeta and NIK activities seem to be dependent of a restricted set of Ser in both proteins. Serine 141-144 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-34 17298882-4 2007 The physical interaction between VDR and p65 was absent in VDR(-/-) MEFs, which may free p65 and increase its activity. mefs 68-72 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 41-44 17298882-4 2007 The physical interaction between VDR and p65 was absent in VDR(-/-) MEFs, which may free p65 and increase its activity. mefs 68-72 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 89-92 18449455-8 2007 However, the major outcome was that the combined effect of Se supplementation and GSH depletion resulted in reduced expression of cjun and cfos while p65 expression increased. Selenium 59-61 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 150-153 18449455-8 2007 However, the major outcome was that the combined effect of Se supplementation and GSH depletion resulted in reduced expression of cjun and cfos while p65 expression increased. Glutathione 82-85 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 150-153 16806824-3 2006 We show that chronic cholesterol depletion achieved with lipoprotein-deficient serum (LPDS) and 25-hydroxycholesterol (25-HC) treatment resulted in a significant increase in NFkappaB-dependent transcription, NFkappaB-DNA binding, IkappaBalpha degradation and p65/NFkappaB translocation to the nucleus, and the addition of exogenous cholesterol reversed these effects. Cholesterol 21-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 259-262 17541474-5 2007 Consistent with the inhibitory effect on iNOS and COX-2 expression, inflexinol also inhibited transcriptional and DNA binding activity of NF-kappaB via inhibition of IkappaB degradation as well as p50 and p65 translocation into nucleus. ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate 68-78 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 205-208 16806824-3 2006 We show that chronic cholesterol depletion achieved with lipoprotein-deficient serum (LPDS) and 25-hydroxycholesterol (25-HC) treatment resulted in a significant increase in NFkappaB-dependent transcription, NFkappaB-DNA binding, IkappaBalpha degradation and p65/NFkappaB translocation to the nucleus, and the addition of exogenous cholesterol reversed these effects. Hydroxycholesterols 99-117 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 259-262 16806824-3 2006 We show that chronic cholesterol depletion achieved with lipoprotein-deficient serum (LPDS) and 25-hydroxycholesterol (25-HC) treatment resulted in a significant increase in NFkappaB-dependent transcription, NFkappaB-DNA binding, IkappaBalpha degradation and p65/NFkappaB translocation to the nucleus, and the addition of exogenous cholesterol reversed these effects. Cholesterol 106-117 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 259-262 16806824-5 2006 Here, we found that inhibition of p38 MAPK with the specific inhibitor SB203580 blocked the increase in NFkappaB activity, IkappaBalpha degradation and p65/NFkappaB translocation to the nucleus induced by cholesterol depletion. SB 203580 71-79 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 152-155 16806824-5 2006 Here, we found that inhibition of p38 MAPK with the specific inhibitor SB203580 blocked the increase in NFkappaB activity, IkappaBalpha degradation and p65/NFkappaB translocation to the nucleus induced by cholesterol depletion. Cholesterol 205-216 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 152-155 16806824-8 2006 We observed that cholesterol depletion increased the p65/NFkappaB transactivation capacity. Cholesterol 17-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 16806824-11 2006 Together, our results demonstrate that cholesterol depletion induces NFkappaB transcriptional activity, not only by affecting the IkappaBalpha degradation and the translocation of p65/NFkappaB to the nucleus, but also regulating the p65/NFkappaB transactivating potential through a p38 MAPK/MSK1 mediated pathway. Cholesterol 39-50 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 180-183 16806824-11 2006 Together, our results demonstrate that cholesterol depletion induces NFkappaB transcriptional activity, not only by affecting the IkappaBalpha degradation and the translocation of p65/NFkappaB to the nucleus, but also regulating the p65/NFkappaB transactivating potential through a p38 MAPK/MSK1 mediated pathway. Cholesterol 39-50 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 233-236 16793190-8 2006 SB203580 inhibited LPS-induced serine phosphorylation, degradation of IkappaB-alpha, and tyrosine phosphorylation of p65 NF-kappaB. SB 203580 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-130 16782536-5 2006 Renal tissue of the BXSB mice was prepared for assaying inhibitory activity of DHA on NF-kappaB, p65 and IkappaB-alpha protein expression in vivo. dihydroarteannuin 79-82 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 97-100 16483740-2 2006 In order to unravel mechanisms underlying teratogen-induced cell death, we tried in our present study to assess the involvement of the p65 subunit of NF-kappaB in the response of mouse embryonic fibroblasts (MEFs) to the anti-cancer drug methotrexate (MTX), using p65 knockout MEFs (p65(-/-)). Methotrexate 238-250 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 135-138 16483740-2 2006 In order to unravel mechanisms underlying teratogen-induced cell death, we tried in our present study to assess the involvement of the p65 subunit of NF-kappaB in the response of mouse embryonic fibroblasts (MEFs) to the anti-cancer drug methotrexate (MTX), using p65 knockout MEFs (p65(-/-)). Methotrexate 252-255 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 135-138 16483740-4 2006 Also, a different pattern of intracellular localization of p65 in WT cells as well as IkappaBalpha and Bax in both cell lines was detected in response to MTX. Methotrexate 154-157 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-62 16483740-5 2006 Altogether, our results implicate the p65 subunit of NF-kappaB to play an important role in the response of embryonic cells to MTX. Methotrexate 127-130 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 38-41 16704919-5 2006 An increase in testicular mRNA abundance of redox-regulated p50 and p65 subunits of NF-kappaB was observed after TBHP treatment. tert-Butylhydroperoxide 113-117 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 16782536-8 2006 The results demonstrated that DHA decreased the expression of NF-kappaB subunit p65 protein and the activation of NF-kappaB in the renal tissue of BXSB mice in vivo. dihydroarteannuin 30-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 80-83 16793190-8 2006 SB203580 inhibited LPS-induced serine phosphorylation, degradation of IkappaB-alpha, and tyrosine phosphorylation of p65 NF-kappaB. Tyrosine 89-97 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-130 16738480-5 2006 Moreover, the synthesis of nuclear factor kappaB protein (p65) and inhibitory factor kappaBalpha decreased when RU486 and metyrapone treatment was given before restraint stress. Mifepristone 112-117 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 58-61 16765938-5 2006 Dipyridamole inhibited the nuclear factor kappa B (NF-kappaB) signaling pathway as demonstrated by inhibition of the inhibitor of NF-kappaB (IkappaB) phosphorylation, IkappaB degradation, p65 translocation from the cytosol to the nucleus, and transcription of the reporter gene. Dipyridamole 0-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 188-191 16474181-6 2006 Resveratrol blunted TPA-induced phosphorylation of p65 and its interaction with CBP/p300, rendering NF-kappaB transcriptionally inactive. Resveratrol 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 16474181-6 2006 Resveratrol blunted TPA-induced phosphorylation of p65 and its interaction with CBP/p300, rendering NF-kappaB transcriptionally inactive. Tetradecanoylphorbol Acetate 20-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 16738480-5 2006 Moreover, the synthesis of nuclear factor kappaB protein (p65) and inhibitory factor kappaBalpha decreased when RU486 and metyrapone treatment was given before restraint stress. Metyrapone 122-132 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 58-61 16713561-2 2006 The CYLD gene encodes a deubiquitinase that removes lysine 63-linked ubiquitin chains from TRAF2 and inhibits p65/p50 NF-kappaB activation. Lysine 52-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 110-113 16732525-7 2006 This occurred at the transcriptional level, since the gingerol compounds decreased LPS-induced IkappaB-alpha degradation, prevented nuclear translocation of NF-kappaB p65 and reduced NF-kappaB activity in a concentration-dependent manner. gingerol 54-62 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 167-170 16796922-11 2006 (2) In the tissue sections NF-kappaB p65 was positive mainly in the nucleus in the 3 DSS-treated groups without significant differences among these 3 groups, and was mainly positive in the cytoplasm in the control group. dss 85-88 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 37-40 16652422-8 2006 Immunohistochemical analysis revealed that p65, phosphorylated IkB-a, and MMP-9 were more strongly stained in the acinar cells of control mice than in cepharanthin-treated mice. cepharanthine 151-163 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 43-46 16627788-7 2006 RESULTS: Upregulation of the p65 subunit of NF-kappaB and subsequent p65 phosphorylation at serine 536 was detected in the Gpx1(-/-) brains after stroke. Serine 92-98 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-72 16672661-3 2006 Activation of group I metabotropic glutamate receptors (GpI-mGluRs) with the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) resulted in a time-dependent increase in DNA binding activity of p50, p65, and c-Rel in area CA1 of the hippocampus. 3,5-dihydroxyphenylglycine 85-115 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 193-196 16672661-3 2006 Activation of group I metabotropic glutamate receptors (GpI-mGluRs) with the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) resulted in a time-dependent increase in DNA binding activity of p50, p65, and c-Rel in area CA1 of the hippocampus. 3,5-dihydroxyphenylglycine 117-121 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 193-196 16651419-5 2006 p50/p65 heterodimer increased the mRNA expression of Bcl-2 and Bcl-xL and decreased etoposide-induced caspase activities and cell death. Etoposide 84-93 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 4-7 16614396-7 2006 CP at the same doses inhibited TPA-induced nuclear translocation of p65 and subsequent DNA binding of NF-kappaB at 1 h by blocking the degradation of IkappaBalpha in mouse skin. Tetradecanoylphorbol Acetate 31-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 16594979-10 2006 NFkappaBia, an important regulator of NFkappaB function and Rela, an NFkappaB-binding partner, were both regulated by ethanol. Ethanol 118-125 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 60-64 16463048-11 2006 In addition, gemfibrozil reduced the expression of the genes encoding nuclear factor kappa B (NF-kappaB) subunit, p65, the NF-kappaB-dependent chemokine monocyte chemoattractant protein-1, and tissue factor. Gemfibrozil 13-24 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-117 16307761-4 2006 Treatment of the transfectant RAW 264.7 cells with irigenin reduced the level of nuclear factor-kappaB (NF-kappaB) activity, also effectively lowered NF-kappaB binding measured by electrophoretic mobility shift assay (EMSA), which was associated with decreased p65 protein levels in the nucleus. irigenin 51-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 261-264 16431847-9 2006 These results suggest that c-Src and Lck act for silica-induced NF-kappaB activation by mediating the tyrosine phosphorylations of IkappaB-alpha and p65 NF-kappaB. Silicon Dioxide 49-55 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 149-162 16477650-2 2006 The ganglioside binding to IL-15 inhibited the proinflammatory effects of the cytokine, reducing IL-15-dependent T-cell proliferation as well as mRNA expression for IL-15Ralpha, p65, and NFATc2 in the N13 murine microglial cell line. Gangliosides 4-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 178-181 16397116-9 2006 In summary, TNF-alpha efficiently induces UPase gene expression through a NF-kappaB subunit p65-dependent pathway enhancing cell sensitivity to 5"-DFUR. doxifluridine 144-151 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 92-95 16431847-0 2006 Src tyrosine kinases mediate crystalline silica-induced NF-kappaB activation through tyrosine phosphorylation of IkappaB-alpha and p65 NF-kappaB in RAW 264.7 macrophages. Silicon Dioxide 41-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 131-144 16431847-9 2006 These results suggest that c-Src and Lck act for silica-induced NF-kappaB activation by mediating the tyrosine phosphorylations of IkappaB-alpha and p65 NF-kappaB. Tyrosine 102-110 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 149-162 16431847-0 2006 Src tyrosine kinases mediate crystalline silica-induced NF-kappaB activation through tyrosine phosphorylation of IkappaB-alpha and p65 NF-kappaB in RAW 264.7 macrophages. Tyrosine 4-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 131-144 16431847-4 2006 Furthermore, these kinase inhibitors suppressed silica-induced tyrosine phosphorylation of IkappaB-alpha and p65 NF-kappaB. Silicon Dioxide 48-54 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-122 16434028-6 2006 In addition, in mouse primary calvarial osteoblasts, kaempferol but not quercetin blocked TNFalpha-induced translocation of the nuclear factor kappaB (NF-kappaB) subunit p65 from the cytoplasm to the nucleus. kaempferol 53-63 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 170-173 16431847-4 2006 Furthermore, these kinase inhibitors suppressed silica-induced tyrosine phosphorylation of IkappaB-alpha and p65 NF-kappaB. Tyrosine 63-71 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 109-122 16249388-4 2006 Although nuclear expression of both p50 and p65 NF-kappaB increased on H2O2 exposure, nuclear c-rel level was inhibited. Hydrogen Peroxide 71-75 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 44-57 16517719-5 2006 GITR engagement using DTA-1, an agonistic mAb against GITR, in the presence of TCR signals, augmented IL-2 production, the expression of activation markers, cell cycle progression, and the nuclear translocations of NF-kappaB p50 and p65. dta-1 22-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 233-236 16188363-7 2006 Moreover, addition of 100 microM CLA significantly diminished LPS-IFN-gamma-induced protein degradation of inhibitor kappaB-alpha (IkappaB-alpha) and the protein expression of phosphorylated IkappaB-alpha in the cytosolic fraction as well as nuclear p65 expression (P < 0.05). Linoleic Acids, Conjugated 33-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 250-253 16049962-9 2006 Fas expression increased in the inulin group between 9-15 weeks (p = 0.034) and correlated negatively with p65 (p = 0.03). ammonium ferrous sulfate 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-110 16302981-0 2005 Inhibition of proinflammatory cytokine expression by NF-kappaB (p65) antisense oligonucleotide in Helicobacter pylori-infected mice. Oligonucleotides 79-94 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-67 16338964-5 2006 The SFK antagonist 4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazolo(3,4-d)pyrimidine (PP2) dramatically inhibited IL-1beta-mediated induction of endogenous NO production as measured by the Griess reaction, as well as the induction of NF-kappaB p50/p65 DNA-binding activity in gel shift assays and the activity of an NF-kappaB-responsive promoter-reporter construct transiently transfected into the cells. AG 1879 19-83 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 247-250 16183703-9 2006 Moreover, cardamomin suppressed transcriptional activity and phosphorylation of Ser536 of RelA/p65 subunit of NF-kappaB. cardamonin 10-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-94 16302981-7 2005 Pretreatment with nuclear factor-kappaB (p65) antisense oligonucleotide inhibited the activation of nuclear factor-kappaB and the expressions of tumor necrosis factor-alpha and interleukin-1beta in H. pylori-infected gastric mucosa. Oligonucleotides 56-71 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 41-44 16325549-8 2005 By means of electrophoretic mobility shift assays we demonstrate that sesquiterpene lactones inhibit Yersinia-triggered activation of NF-kappaB by inhibiting Rel p65, but not Rel p50. sesquiterpene lactones 70-92 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 162-165 16325549-4 2005 Sesquiterpene lactones inhibit the transcription factor NF-kappaB by alkylating the p65 subunit. sesquiterpene lactones 0-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 84-87 15982733-8 2005 We found that the cell lines LBR-V160 and LBR-D160 (resistant to vincristine and doxorubicin, respectively) presented higher constitutive NF-kappaB activity than the sensitive LBR- and the active complex contained both p50 and p65 subunits. Vincristine 65-76 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 227-230 16027228-7 2005 We found that parthenolide could effectively inhibit the gene expression mediated by NF-kappaB and the production of bFGF and MMP-1 from cells overexpressing p65, a major subunit of NF-kappaB. parthenolide 14-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 158-161 15982733-8 2005 We found that the cell lines LBR-V160 and LBR-D160 (resistant to vincristine and doxorubicin, respectively) presented higher constitutive NF-kappaB activity than the sensitive LBR- and the active complex contained both p50 and p65 subunits. Doxorubicin 81-92 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 227-230 16183169-6 2005 The inhibition of NF-kappaB/Rel protein expression by antisense oligonucleotides showed that p65 is involved in glutamate-mediated cell death, whereas p50 is involved in inhibitory pathways of the cell death. Oligonucleotides 64-80 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 93-96 16183169-6 2005 The inhibition of NF-kappaB/Rel protein expression by antisense oligonucleotides showed that p65 is involved in glutamate-mediated cell death, whereas p50 is involved in inhibitory pathways of the cell death. Glutamic Acid 112-121 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 93-96 16000698-6 2005 In addition, increased intracellular [Na+] after selective plasma membrane permeabilization by a low concentration of the Na+ ionophore amphotericin B (1 microg/ml) induced dissociation of the PKA catalytic subunit from p65-NF-kappaB and IkappaBalpha. Amphotericin B 136-150 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 220-233 16192349-5 2005 Remarkably, we show that RelA serine-276, the phosphorylation of which is induced by TNF receptor ligation, is crucial for RelA/RelB complex formation and subsequent inhibition of RelB DNA binding. Serine 30-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 25-29 16192349-5 2005 Remarkably, we show that RelA serine-276, the phosphorylation of which is induced by TNF receptor ligation, is crucial for RelA/RelB complex formation and subsequent inhibition of RelB DNA binding. Serine 30-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 123-127 16204946-5 2005 Furthermore, chiisanoside inhibited the nuclear factor-kappaB (NF-kappaB) activation induced by LPS and this was associated with a reduction in p65 protein in the nucleus and with the phosphorylations of ERK1/2 and JNK MAP kinases. chiisanoside 13-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 144-147 16027734-6 2005 However, v-Ras-infected RelA-deficient cells formed colonies in soft agar at an approximately fourfold reduced efficiency compared to v-Ras-transformed control mouse 3T3 and p50-deficient cells. Agar 69-73 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 24-28 16135789-2 2005 Acetylation at lysines 218, 221, and 310 differentially regulates RelA"s DNA binding activity, assembly with IkappaBalpha, and transcriptional activity. Lysine 15-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-70 15523684-8 2005 Compared to other compounds having the potential to inhibit NF-kappaB, DHMEQ is a unique compound that blocks the translocation of NF-kappaB p65 into the nucleus and selectively targets NF-kappaB activated in tumor cells. dehydroxymethylepoxyquinomicin 71-76 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 141-144 16135789-4 2005 Using anti-acetylated lysine 310 RelA antibodies, we detected p300-mediated acetylation of RelA in vitro and in vivo after stimulation of cells with tumor necrosis factor alpha (TNF-alpha). Lysine 22-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-95 16135789-5 2005 Coexpression of catalytically inactive mutants of the catalytic subunit of protein kinase A/mitogen- and stress-activated kinase 1 or IKK1/IKK2, which phosphorylate RelA on serine 276 or serine 536, respectively, sharply inhibited RelA acetylation on lysine 310. Serine 173-179 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 165-169 16135789-5 2005 Coexpression of catalytically inactive mutants of the catalytic subunit of protein kinase A/mitogen- and stress-activated kinase 1 or IKK1/IKK2, which phosphorylate RelA on serine 276 or serine 536, respectively, sharply inhibited RelA acetylation on lysine 310. Serine 187-193 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 165-169 16135789-5 2005 Coexpression of catalytically inactive mutants of the catalytic subunit of protein kinase A/mitogen- and stress-activated kinase 1 or IKK1/IKK2, which phosphorylate RelA on serine 276 or serine 536, respectively, sharply inhibited RelA acetylation on lysine 310. Lysine 251-257 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 165-169 16135789-6 2005 Furthermore, phosphorylation of RelA on serine 276 or serine 536 increased assembly of phospho-RelA with p300, which enhanced acetylation on lysine 310. Serine 40-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 32-36 16135789-6 2005 Furthermore, phosphorylation of RelA on serine 276 or serine 536 increased assembly of phospho-RelA with p300, which enhanced acetylation on lysine 310. Serine 40-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-99 16135789-6 2005 Furthermore, phosphorylation of RelA on serine 276 or serine 536 increased assembly of phospho-RelA with p300, which enhanced acetylation on lysine 310. Serine 54-60 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-99 16135789-6 2005 Furthermore, phosphorylation of RelA on serine 276 or serine 536 increased assembly of phospho-RelA with p300, which enhanced acetylation on lysine 310. Lysine 141-147 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 32-36 16135789-6 2005 Furthermore, phosphorylation of RelA on serine 276 or serine 536 increased assembly of phospho-RelA with p300, which enhanced acetylation on lysine 310. Lysine 141-147 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-99 16135789-7 2005 Reconstitution of RelA-deficient murine embryonic fibroblasts with RelA S276A or RelA S536A decreased TNF-alpha-induced acetylation of lysine 310 and expression of the endogenous NF-kappaB-responsive E-selectin gene. Lysine 135-141 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 18-22 16135789-7 2005 Reconstitution of RelA-deficient murine embryonic fibroblasts with RelA S276A or RelA S536A decreased TNF-alpha-induced acetylation of lysine 310 and expression of the endogenous NF-kappaB-responsive E-selectin gene. Lysine 135-141 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 67-71 16135789-7 2005 Reconstitution of RelA-deficient murine embryonic fibroblasts with RelA S276A or RelA S536A decreased TNF-alpha-induced acetylation of lysine 310 and expression of the endogenous NF-kappaB-responsive E-selectin gene. Lysine 135-141 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 67-71 16135789-8 2005 These findings indicate that the acetylation of RelA at lysine 310 is importantly regulated by prior phosphorylation of serines 276 and 536. Lysine 56-62 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 48-52 16135789-8 2005 These findings indicate that the acetylation of RelA at lysine 310 is importantly regulated by prior phosphorylation of serines 276 and 536. Serine 120-127 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 48-52 15972635-7 2005 TCDD treatment, in vivo and in vitro, led to colocalization and translocation of NF-kappaB subunits (p50, p65) to the nucleus in stromal but not T cells from AhR wild-type mice. Polychlorinated Dibenzodioxins 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 106-109 15849198-0 2005 Bruton"s tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide. Serine 99-105 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 92-95 15849198-7 2005 Additionally LFM-A13 impaired phosphorylation of serine 536 on p65 induced by LPS in HEK293-TLR4 cells, and in Xid macrophages this response was impaired. Serine 49-55 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 63-66 15849198-9 2005 It is required for the signaling pathway activated by TLR4, which culminates in phosphorylation of p65 on serine 536 promoting transactivation by NFkappaB. Serine 106-112 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-102 15829434-7 2005 Furthermore, the nuclear translocation of p65 by LPS was inhibited by amentoflavone. amentoflavone 70-83 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 42-45 15735738-6 2005 Pretreatment with [6]-gingerol resulted in a decrease in both TPA-induced DNA binding and transcriptional activities of NF-kappaB through suppression of IkappaBalpha degradation and p65 nuclear translocation. gingerol 18-30 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 182-185 15735738-6 2005 Pretreatment with [6]-gingerol resulted in a decrease in both TPA-induced DNA binding and transcriptional activities of NF-kappaB through suppression of IkappaBalpha degradation and p65 nuclear translocation. Tetradecanoylphorbol Acetate 62-65 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 182-185 15735738-7 2005 Phosphorylation of both IkappaBalpha and p65 was substantially blocked by [6]-gingerol. gingerol 74-86 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 41-44 15735738-8 2005 In addition, [6]-gingerol inhibited TPA-stimulated interaction of phospho-p65-(Ser-536) with cAMP response element binding protein-binding protein, a transcriptional coactivator of NF-kappaB. gingerol 13-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-77 15735738-8 2005 In addition, [6]-gingerol inhibited TPA-stimulated interaction of phospho-p65-(Ser-536) with cAMP response element binding protein-binding protein, a transcriptional coactivator of NF-kappaB. Tetradecanoylphorbol Acetate 36-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-77 15735738-8 2005 In addition, [6]-gingerol inhibited TPA-stimulated interaction of phospho-p65-(Ser-536) with cAMP response element binding protein-binding protein, a transcriptional coactivator of NF-kappaB. Serine 79-82 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-77 15735738-8 2005 In addition, [6]-gingerol inhibited TPA-stimulated interaction of phospho-p65-(Ser-536) with cAMP response element binding protein-binding protein, a transcriptional coactivator of NF-kappaB. Cyclic AMP 93-97 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-77 15963474-5 2005 Western blotting analysis indicated that delphinidin inhibited the degradation of IkappaB-alpha, nuclear translocation of p65 and CCAAT/enhancer-binding protein (C/EBP)delta and phosphorylation of c-Jun, but not CRE-binding protein (CREB). delphinidin 41-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 122-125 15866483-7 2005 Increased NF-kappaB activity after palmitate exposure was associated with enhanced protein-protein interaction between PPARbeta/delta and p65. Palmitates 35-44 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 138-141 16013440-8 2005 However, immunoflurescence studies of NF-kB revealed that the inhibition of nuclear translocation of NF-kB p65, a transcription factor required for VEGF gene expression, in curcumin-treated EAT cells. Curcumin 173-181 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-110 15525791-9 2005 Taken together, these results suggest that ethyl pyruvate inhibits DNA-binding by covalently modifying p65 at Cys(38). ethyl pyruvate 43-57 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 103-106 15525791-9 2005 Taken together, these results suggest that ethyl pyruvate inhibits DNA-binding by covalently modifying p65 at Cys(38). Cysteine 110-113 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 103-106 15525791-0 2005 Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65. ethyl pyruvate 0-14 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 15537821-5 2005 Further study demonstrated that the LPS-induced nuclear factor (NF)-kappaB/Rel DNA binding activity and NF-kappaB/Rel-dependent reporter gene activity were significantly inhibited by glabridin in RAW 264.7 cells and that this effect was mediated through the inhibition of inhibitory factor-kappaB degradation and p65 nuclear translocation. glabridin 183-192 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 313-316 15525791-10 2005 We conclude that some of the beneficial anti-inflammatory effects of ethyl pyruvate may be due to modification of p65, thereby inhibiting signaling via the NF-kappaB pathway. ethyl pyruvate 69-83 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-117 16116955-4 2005 Curcumin could suppress the expression of NFkappaB p65. Curcumin 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 16277688-8 2005 In RA FLS stimulated with tumor necrosis factor-alpha, activities of NF-kappaB components p65 and p50 were inhibited by DHMEQ, leading to suppressed expression of the key inflammatory cytokine IL-6, CC chemokine ligand-2 and -5, matrix metalloproteinase-3, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1. dehydroxymethylepoxyquinomicin 120-125 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 90-93 15199053-8 2004 We concluded that 15d-PGJ(2) may help to control NF-kappaB signaling and normal intestinal homeostasis to the enteric microflora by modulating RelA phosphorylation in IEC through altered protein phosphatase 2A activity. 15d-pgj 18-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 143-147 15614131-5 2005 Ethacrynic acid impaired DNA binding of wild-type p65 subunits of NF-kappaB in cells. Ethacrynic Acid 0-15 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 50-53 15614131-6 2005 However, DNA binding of a Cys--> Ser p65 mutant was not inhibited by ethacrynic acid, suggesting that ethacrynic acid inhibits DNA binding by alkylating p65 at Cys. Cysteine 26-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-43 15614131-6 2005 However, DNA binding of a Cys--> Ser p65 mutant was not inhibited by ethacrynic acid, suggesting that ethacrynic acid inhibits DNA binding by alkylating p65 at Cys. Cysteine 26-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 156-159 15614131-6 2005 However, DNA binding of a Cys--> Ser p65 mutant was not inhibited by ethacrynic acid, suggesting that ethacrynic acid inhibits DNA binding by alkylating p65 at Cys. Serine 36-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-43 15614131-6 2005 However, DNA binding of a Cys--> Ser p65 mutant was not inhibited by ethacrynic acid, suggesting that ethacrynic acid inhibits DNA binding by alkylating p65 at Cys. Ethacrynic Acid 105-120 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-43 15614131-6 2005 However, DNA binding of a Cys--> Ser p65 mutant was not inhibited by ethacrynic acid, suggesting that ethacrynic acid inhibits DNA binding by alkylating p65 at Cys. Ethacrynic Acid 105-120 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 156-159 15614131-6 2005 However, DNA binding of a Cys--> Ser p65 mutant was not inhibited by ethacrynic acid, suggesting that ethacrynic acid inhibits DNA binding by alkylating p65 at Cys. Cysteine 163-166 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 156-159 15623648-6 2004 Consistent with this, silibinin inhibited doxorubicin-caused increased translocation of p65 and p50 from cytosol to nucleus. Silybin 22-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 15623648-6 2004 Consistent with this, silibinin inhibited doxorubicin-caused increased translocation of p65 and p50 from cytosol to nucleus. Doxorubicin 42-53 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 88-91 15336524-4 2004 Both analysis by immunocytochemistry and of immunoblots revealed that NF-kappaB-p65 was translocated into the nuclei following 6-OHDA but not MPP(+)-treatment. Oxidopamine 127-133 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 80-83 15336524-6 2004 A competition assay indicated that not only NF-kappaB-p65 but also -p50 is involved in 6-OHDA-induced NF-kappaB activity. Oxidopamine 87-93 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 54-57 15326199-4 2004 The serum-induced intracellular calcium peak was essential for subsequent NF-kappaB activation (measured by real-time imaging of the dynamic p65 and IkappaBalpha fluorescent fusion proteins), cyclin D1 (CD1) promoter-directed transcription (measured by real-time luminescence imaging of CD1 promoter-directed firefly luciferase activity), and progression to cell division. Calcium 32-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 141-144 15199053-0 2004 15-deoxy-delta12,14-prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity. 15-deoxy-delta(12,14)-prostaglandin J2 0-36 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 100-104 15199053-1 2004 We have previously shown that non-pathogenic Gram-negative Bacteroides vulgatus induces transient RelA phosphorylation (Ser-536), NF-kappaB activity, and pro-inflammatory gene expression in native and intestinal epithelial cell (IEC) lines. Serine 120-123 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 98-102 15199053-2 2004 We now demonstrate that 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) but not prostaglandin E(2) inhibits lipopolysaccharide (LPS) (B. vulgatus)/LPS (Escherichia coli)-induced RelA phosphorylation and interleukin-6 gene expression in the colonic epithelial cell line CMT-93. 15-deoxy-delta(12,14)-prostaglandin j 24-61 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 184-188 15199053-5 2004 In addition, 15d-PGJ(2) but not the synthetic high affinity PPARgamma ligand rosiglitazone triggered ERK1/2 phosphorylation in IEC, and most importantly, MEK1 inhibitor PD98059 reversed the inhibitory effect of 15dPGJ(2) on LPS-induced RelA phosphorylation and interleukin-6 gene expression. 15d-pgj 13-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 236-240 15199053-5 2004 In addition, 15d-PGJ(2) but not the synthetic high affinity PPARgamma ligand rosiglitazone triggered ERK1/2 phosphorylation in IEC, and most importantly, MEK1 inhibitor PD98059 reversed the inhibitory effect of 15dPGJ(2) on LPS-induced RelA phosphorylation and interleukin-6 gene expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 169-176 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 236-240 15199053-6 2004 Calyculin A, a specific phosphoserine/phospho-threonine phosphatase inhibitor increased the basal phosphorylation of RelA and reversed the inhibitory effect of 15d-PGJ(2) on LPS-induced RelA phosphorylation. calyculin A 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 117-121 15199053-6 2004 Calyculin A, a specific phosphoserine/phospho-threonine phosphatase inhibitor increased the basal phosphorylation of RelA and reversed the inhibitory effect of 15d-PGJ(2) on LPS-induced RelA phosphorylation. calyculin A 0-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 186-190 15531295-7 2004 We found that the nuclear translocation of p65, p50, c-Rel subunits of NF-kappaB and other transcription factors such as ATF-2, c-Fos and CREB were inhibited by the treatment of piperine. piperine 178-186 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 43-46 15531297-0 2004 Administration of antisense phosphorothioate oligonucleotide to the p65 subunit of NF-kappaB inhibits established asthmatic reaction in mice. Phosphorothioate Oligonucleotides 28-60 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 15505232-6 2004 Accordingly, mouse embryonic fibroblasts (MEF) from p65-/- mice were more susceptible to HEMA-induced apoptosis than were wild-type controls. hydroxyethyl methacrylate 89-93 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 52-55 15464059-5 2004 Further investigation showed that melatonin significantly attenuated the nitration of cytoplasmic IkappaB-alpha, inhibited the degradation of IkappaB-alpha, and blocked the translocation of p65/RelA into the nuclei. Melatonin 34-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 190-193 15464059-5 2004 Further investigation showed that melatonin significantly attenuated the nitration of cytoplasmic IkappaB-alpha, inhibited the degradation of IkappaB-alpha, and blocked the translocation of p65/RelA into the nuclei. Melatonin 34-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 194-198 15378410-4 2004 A two days pre-treatment of fibroblasts with alpha-difluoromethylornithine (DFMO), which caused polyamine depletion, provoked a slight activating effect when given alone, but markedly inhibited the etoposide-induced increases in p65 DNA binding and phosphorylation. Eflornithine 45-74 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 229-232 15378410-4 2004 A two days pre-treatment of fibroblasts with alpha-difluoromethylornithine (DFMO), which caused polyamine depletion, provoked a slight activating effect when given alone, but markedly inhibited the etoposide-induced increases in p65 DNA binding and phosphorylation. Eflornithine 76-80 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 229-232 15155458-4 2004 Further, using mouse embryo fibroblast (MEF) null cells and antisense oligonucleotides to inhibit expression of NF-kappaB family members, we demonstrate that the p65 subunit of NF-kappaB is uniquely involved in p53 inhibition. Oligonucleotides 70-86 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 162-165 15212763-7 2004 Functional analysis demonstrated that Ad5NIK-induced NF-kappaB transcriptional activity, IL-6 mRNA expression and RelA phosphorylation are inhibited by the p38 inhibitor SB203580, suggesting a role for this MAPK in NIK signaling to NF-kappaB. SB 203580 170-178 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 114-118 15386188-4 2004 Furthermore, 23-hydroxyursolic acid ( 2) inhibited the LPS-induced DNA binding activity of nuclear factor- kappaB (NF- kappaB), which was associated with a decrease of p65 protein levels in the nucleus. 23-hydroxyursolic acid 13-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 168-171 14686903-7 2003 Glutamate induced a rapid reduction of IkappaBalpha levels and nuclear translocation of the NF-kappaB subunit p65. Glutamic Acid 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 110-113 15256219-7 2004 Exercise increased nuclear p65, CINC-1, and MCP-1 in gastrocnemius muscle cells, but these changes were ameliorated by the high alpha-tocopherol diet. alpha-Tocopherol 128-144 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 27-30 15122339-2 2004 Here, we show that Aplidin induces c-JUN, JUN B, JUN D, c-FOS, FRA-1 and FOS B genes of the activator-protein (AP)-1 family, and also p65/RELA, a major component of nuclear factor-kappa B (NF-kappaB). plitidepsin 19-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 134-137 15122339-2 2004 Here, we show that Aplidin induces c-JUN, JUN B, JUN D, c-FOS, FRA-1 and FOS B genes of the activator-protein (AP)-1 family, and also p65/RELA, a major component of nuclear factor-kappa B (NF-kappaB). plitidepsin 19-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 138-142 15033982-5 2004 In contrast, an IL-1beta-induced phosphorylation of serine residues in NF-kappaB p65 subunit was observed in EMT-6J, but not in EMT-6H, cells. Serine 52-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 81-84 15033982-6 2004 This IL-1beta-induced phosphorylation of p65 was specifically prevented by pretreatment of EMT-6J cells with the casein kinase II inhibitor DRB. Dichlororibofuranosylbenzimidazole 140-143 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 41-44 15368442-6 2004 In ob/ob mice, double insults with alcohol and LPS augmented proinflammatory responses mediated by increased degradation of inhibitory kappaB (IkappaB)-alpha and IkappaB-beta and preferential induction of the p65/p50 NF-kappaB heterodimer. Alcohols 35-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 209-212 15048731-9 2004 LPS and poly-I-C induced translocation of NF-kappa B p65 to the nucleus and up-regulation of kinin B(1) and B(2) receptor mRNA. Poly C 8-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 14651944-4 2004 Additionally, 5-HT and R-DPAT treatment increased intranuclear levels of the p50 and p65 subunits of NF-kappaB. r-dpat 23-29 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 85-88 15254665-0 2004 Expression of p65 gene in experimental colon cancer under the influence of 5-fluorouracil given alone and in combination with hormonal modulation. Fluorouracil 75-89 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 14-17 15254665-1 2004 The effect of tamoxifen (TAM), lanreotide (LAN) and 5-fluorouracil (5-FU), given separately or together, on p65 gene expression in murine Colon 38 cancer was investigated by RT-PCR method. Fluorouracil 52-66 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 108-111 15254665-1 2004 The effect of tamoxifen (TAM), lanreotide (LAN) and 5-fluorouracil (5-FU), given separately or together, on p65 gene expression in murine Colon 38 cancer was investigated by RT-PCR method. Fluorouracil 68-72 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 108-111 15254665-6 2004 After a combined treatment with TAM and LAN a percentage of p65 positive cases was similar to that of the control group and equaled approximately 60%. Tamoxifen 32-35 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 60-63 15254665-11 2004 In the group with 5-FU alone the expression of p65 was present in about 80% of samples. Fluorouracil 18-22 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 47-50 15254665-13 2004 In the group treated with a combination of TAM and 5-FU all analyzed cases showed the presence of p65 gene expression. Tamoxifen 43-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 98-101 15254665-13 2004 In the group treated with a combination of TAM and 5-FU all analyzed cases showed the presence of p65 gene expression. Fluorouracil 51-55 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 98-101 15254665-15 2004 Based on these findings we conclude that p65 gene expression in murine Colon 38 cancer tissues can be modulated via chemotherapy (5-FU) and also via hormonal modulation (TAM and LAN). Fluorouracil 130-134 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 41-44 12844482-8 2003 Curcumin treatment attenuated TPA- stimulated NF-kappaB activation in mouse skin, which was associated with its blockade of degradation of the inhibitory protein IkappaBalpha and also of subsequent translocation of the p65 subunit to nucleus. Curcumin 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 219-222 14525807-8 2003 In vitro, treatment with Y-27632 inhibited p65 phosphorylation and degradation of IkappaBalpha in mouse peritoneal macrophages and significantly inhibited concanavalin A-induced proliferation of spleen-derived T cells (P<0.001). Y 27632 25-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 43-46 12874295-8 2003 Similar effects were obtained when the conserved serine in RelA was mutated. Serine 49-55 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-63 12963487-2 2003 When T lymphoma cells were treated with the soy isoflavone genistein, a marked reduction in nuclear NF-kappa B levels was detectable predominantly for the p50/p50 homodimer and p50/p65 heterodimer. Isoflavones 48-58 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 181-184 12963487-2 2003 When T lymphoma cells were treated with the soy isoflavone genistein, a marked reduction in nuclear NF-kappa B levels was detectable predominantly for the p50/p50 homodimer and p50/p65 heterodimer. Genistein 59-68 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 181-184 14724828-3 2003 In 2 variations of the model an antisense oligonucleotide for nuclear factor kappa B (NF-kappa B) p65 was given prophylactically or therapeutically to block chronic inflammation-associated fibrosis. Oligonucleotides 42-57 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 98-101 14750024-0 2003 Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-kappaB. sauchinone 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 127-131 14750024-5 2003 Further analysis revealed that transactivation activity of RelA subunit of NF-kappaB was dose-dependently suppressed in the presence of sauchinone. sauchinone 136-146 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-63 14750024-6 2003 Taken together, our results suggested that sauchinone could inhibit production of NO in LPS-stimulated RAW264.7 cells through the suppression of NF-kappaB by inhibiting transactivation activity of RelA subunit. sauchinone 43-53 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 197-201 14633691-4 2003 By using wild-type and Ikkbeta gene knockout (Ikkbeta(-/-)) mouse embryo fibroblasts, we found that IKKbeta deficiency results in prolongation of arsenic-induced JNK activation, which was not due to the decreased expression of GADD45beta or X-linked Inhibitor of Apoptosis (XIAP), as suggested previously for RelA(-/-) cells treated with tumor necrosis factor alpha. Arsenic 146-153 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 309-313 14580677-5 2003 Treatment with antisense PDK1 oligonucleotides reduces PDK1 expression and inhibits the stimulation of Akt phosphorylation by p65. Oligonucleotides 30-46 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 126-129 12964033-8 2003 Furthermore, 20 mg/kg GdCl3 decreased the levels of cNOS, PKC and NF-kappaB p65 expression by 26.6, 68 and 64%, respectively. gadolinium chloride 22-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 76-79 12842894-0 2003 Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. Serine 76-82 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 69-72 12842894-2 2003 Here, we characterized the intracellular signaling pathway leading to phosphorylation of p65 on Ser-536 using a novel anti-phospho-p65 (Ser-536) antibody. Serine 96-99 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 89-92 12842894-2 2003 Here, we characterized the intracellular signaling pathway leading to phosphorylation of p65 on Ser-536 using a novel anti-phospho-p65 (Ser-536) antibody. Serine 96-99 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 131-134 12842894-2 2003 Here, we characterized the intracellular signaling pathway leading to phosphorylation of p65 on Ser-536 using a novel anti-phospho-p65 (Ser-536) antibody. Serine 136-139 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 89-92 12842894-2 2003 Here, we characterized the intracellular signaling pathway leading to phosphorylation of p65 on Ser-536 using a novel anti-phospho-p65 (Ser-536) antibody. Serine 136-139 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 131-134 12842894-3 2003 The Ser-536 of endogenous p65 was rapidly phosphorylated in response to a wide variety of NF-kappaB stimulants including TNF-alpha in the cytoplasm and rapidly dephosphorylated in the nucleus. Serine 4-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 26-29 12844482-8 2003 Curcumin treatment attenuated TPA- stimulated NF-kappaB activation in mouse skin, which was associated with its blockade of degradation of the inhibitory protein IkappaBalpha and also of subsequent translocation of the p65 subunit to nucleus. Tetradecanoylphorbol Acetate 30-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 219-222 12870650-0 2003 Phosphoinositide 3-kinase activity leads to silica-induced NF-kappaB activation through interacting with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB. Silicon Dioxide 44-50 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 193-206 12759356-6 2003 Electrophoretic mobility shift assay using nuclear extracts from TMC-23 chondrocytic cells revealed that the NF-kappaB subunits p50 and p65 bound to the NF-kappaB response elements of the BMP-2 gene. trimethylchlorosilane 65-68 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-139 12870650-0 2003 Phosphoinositide 3-kinase activity leads to silica-induced NF-kappaB activation through interacting with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB. Tyrosine 165-173 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 193-206 12870650-6 2003 Furthermore, tyrosine phosphorylation of NF-kappaB p65 was enhanced in cells stimulated with silica, pervanadate or LPS, and wortmannin substantially inhibited the phosphorylation event induced by the first two stimulants but not LPS. Tyrosine 13-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 12870650-6 2003 Furthermore, tyrosine phosphorylation of NF-kappaB p65 was enhanced in cells stimulated with silica, pervanadate or LPS, and wortmannin substantially inhibited the phosphorylation event induced by the first two stimulants but not LPS. Silicon Dioxide 93-99 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 12870650-6 2003 Furthermore, tyrosine phosphorylation of NF-kappaB p65 was enhanced in cells stimulated with silica, pervanadate or LPS, and wortmannin substantially inhibited the phosphorylation event induced by the first two stimulants but not LPS. pervanadate 101-112 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 12870650-6 2003 Furthermore, tyrosine phosphorylation of NF-kappaB p65 was enhanced in cells stimulated with silica, pervanadate or LPS, and wortmannin substantially inhibited the phosphorylation event induced by the first two stimulants but not LPS. Wortmannin 125-135 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 12870650-8 2003 Our data suggest that p85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB. Tyrosine 119-127 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 207-220 12870650-8 2003 Our data suggest that p85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB. Tyrosine 179-187 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 207-220 12746218-12 2003 Sauchinone (1-30 micro M) inhibited LPS-inducible nuclear NF-kappaB activation and nuclear translocation of p65, which was accompanied by inhibition of I-kappaBalpha phosphorylation. sauchinone 0-10 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 108-111 12759443-3 2003 Here, we reported that LPS induced the phosphorylation of the p65 trans-activation domain on serine 536 in monocytes/macrophages. Serine 93-99 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 62-65 12759443-4 2003 Using mouse embryonic fibroblasts lacking either IKK alpha or IKK beta, we found that IKK beta played an essential role in LPS-induced p65 phosphorylation on serine 536, while IKK alpha was partially required for the p65 phosphorylation. Serine 158-164 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 135-138 12759443-5 2003 The LPS-induced p65 phosphorylation on serine 536 was independent of the phosphatidylinositol 3"-kinase/Akt signaling pathway. Serine 39-45 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 16-19 12759443-6 2003 Furthermore, we found that the phosphorylation on serine 536 increased the p65 transcription activity. Serine 50-56 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 75-78 12759443-7 2003 In summary, our results demonstrate that IKK beta plays an essential role in the LPS-induced p65 phosphorylation on serine 536, which may represent a mechanism to regulate the NF-kappa B transcription activity by LPS. Serine 116-122 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 93-96 12759443-0 2003 IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. Serine 71-77 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-63 12759443-0 2003 IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. Serine 71-77 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-67 12746218-17 2003 These results demonstrate that sauchinone inhibits LPS-inducible iNOS, TNF-alpha and COX-2 expression in macrophages through suppression of I-kappaBalpha phosphorylation and p65 nuclear translocation and of C/EBP and/or AP-1 activation, which may constitute anti-inflammatory effects of the lignan. sauchinone 31-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 174-177 12738649-6 2003 Following induction by IPTG (isopropyl-beta-D-thiogalactopyranoside), both GST-P46 and GST-P65(c) recombinant fusion proteins were recovered by disrupting transformed cells by sonication, purified by affinity chromatography, and then cut with thrombin to release the P46 and P65(c) moieties. Isopropyl Thiogalactoside 23-27 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-94 12738649-6 2003 Following induction by IPTG (isopropyl-beta-D-thiogalactopyranoside), both GST-P46 and GST-P65(c) recombinant fusion proteins were recovered by disrupting transformed cells by sonication, purified by affinity chromatography, and then cut with thrombin to release the P46 and P65(c) moieties. Isopropyl Thiogalactoside 29-67 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 91-94 12738649-12 2003 Both anti-P46 and anti-P65(c) MAbs permitted effective detection by indirect immunofluorescence and indirect immunoperoxidase assay of M. hyopneumoniae in, respectively, frozen and formalin-fixed, paraffin-embedded lung sections from pigs that were killed after the 6- to 7-week observation period. Formaldehyde 181-189 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 23-26 12736120-5 2003 As shown by electrophoretic mobility shift assays (EMSAs), DMXAA induced in vitro translocation of NF-kappaB (p50 and p65 subunits) into the nucleus of 70Z/3 cells, but not of 1.3E2 cells. vadimezan 59-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 118-121 12757742-10 2003 STE also stimulated IFN-gamma-induced activation of NF-kappaB p50 but reduced nuclear localization of IFN-gamma- and IFN-gamma/LPS-induced NF-kappaB p65. ste 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 149-152 12073070-0 2002 Abrogated lymphocyte infiltration and lowered CD14 in dextran sulfate induced colitis in mice treated with p65 antisense oligonucleotides. Oligonucleotides 121-137 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-110 12646656-9 2003 Histological and immunocytochemical analysis showed that NaPA inhibited EAE-induced spinal cord mononuclear cell invasion and normalized iNOS, nitrotyrosine, and p65 (the RelA subunit of NF-kappaB) expression within the spinal cord. Acecainide 57-61 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 162-165 12559944-0 2003 Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses. Serine 19-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 47-60 12559944-1 2003 Phosphorylation of several serine residues especially in the transactivation (TA) domain of p65 NF-kappaB subunit has been suggested to be important for its transcriptional activity. Serine 27-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 92-105 12471138-6 2002 Of interest, we detected a significant decrease of NF-kappaB, AP-1, and CREB DNA binding activities by reciprocal competition for these binding sites when either specific cold oligonucleotides (NF-kappaB, AP-1, and CREB) or Abs against various transcription factor subunits (p50, p65, c-Fos, Jun B, c-Jun, and CREB-1) were added. Oligonucleotides 176-192 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 280-283 12473670-9 2003 Moreover, our data revealed that curcumin inhibited the OPN-induced translocation of p65, NF kappa B-DNA binding, and NF kappa B transcriptional activity. Curcumin 33-41 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 85-88 12057007-6 2002 The direct interaction of STAT3 and NF-kappaB p65 was verified in vivo by co-immunoprecipitation and in vitro by pull-down assays with glutathione S-transferase-NF-kappaB p65 fusion protein and in vitro -translated STAT3alpha. Glutathione 135-146 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 46-49 12360479-11 2002 Phosphatidylinositol 3-kinase inhibition by PTEN or wortmannin has an inverse effect compared with tumor necrosis factor alpha on the balance between the p50 and p65 subunits of nuclear factor kappaB. Wortmannin 52-62 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 162-165 12073070-0 2002 Abrogated lymphocyte infiltration and lowered CD14 in dextran sulfate induced colitis in mice treated with p65 antisense oligonucleotides. Dextran Sulfate 54-69 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-110 12073070-4 2002 METHODS: One local dose of p65 antisense oligonucleotides was administered in DSS colitis mice. Oligonucleotides 41-57 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 27-30 12073070-4 2002 METHODS: One local dose of p65 antisense oligonucleotides was administered in DSS colitis mice. Dextran Sulfate 78-81 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 27-30 12073070-7 2002 RESULTS: FACS analysis demonstrated a considerable drop in infiltrating lymphocytes and a drastic reduction in CD14+ cells in mice treated with p65 antisense oligonucleotides. Oligonucleotides 158-174 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 144-147 10936515-6 2000 DEX treatment caused a significant reduction in nuclear c-rel, p65, and p50 protein contents, and these decreases were paralleled by the accumulation of cytoplasmic c-rel, p65, and p50. Dexamethasone 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 63-66 11912207-0 2002 Opposing roles for NF-kappa B/Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-1beta. Glutamic Acid 105-114 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 42-45 11912207-6 2002 Moreover, IL-1beta activated the p50, p65, and c-Rel subunits of NF-kappaB/Rel, whereas glutamate activated only the p50 and p65 proteins. Glutamic Acid 88-97 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 125-128 11912207-7 2002 The inhibition of NF-kappaB/Rel protein expression by antisense oligonucleotides in cerebellar granule cells showed that p65 was involved in glutamate-mediated cell death, whereas c-Rel was essential for IL-1beta-preserved cell survival. Oligonucleotides 64-80 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-124 11912207-7 2002 The inhibition of NF-kappaB/Rel protein expression by antisense oligonucleotides in cerebellar granule cells showed that p65 was involved in glutamate-mediated cell death, whereas c-Rel was essential for IL-1beta-preserved cell survival. Glutamic Acid 141-150 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 121-124 11971183-4 2002 As compared to normal 3T3 cells, RelA-deficient fibroblasts have a spindled morphology, are less adherent to culture dishes, grow to a higher saturation density, and can form colonies in soft agar. Agar 192-196 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 33-37 11789661-0 2002 Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kappaBalpha phosphorylation and of p65 nuclear translocation in macrophages. Dibenzylbutyrolactone 86-107 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 175-178 11789661-6 2002 RESULTS: Arctigenin (1 microM) inhibited lipopolysaccharide (LPS)-inducible nuclear NF-kappaB activation and nuclear translocation of p65, which was accompanied by inhibition of I-kappaBalpha phosphorylation, whereas demethyltraxillagenin was less active. arctigenin 9-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 134-137 11804338-5 2001 The expression of the NF-kappaB p65, c-jun, and p27(Kip1) genes was increased by the TCDD treatment, as previously reported. Polychlorinated Dibenzodioxins 85-89 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 32-35 11682454-14 2001 LPS and UTP co-stimulation additively increased p65 NF-kappa B phosphorylation. Uridine Triphosphate 8-11 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 48-51 11708847-10 2001 Diazoxide pretreatment significantly increased nuclear translocation of p65 which was blocked by protein kinase C (PKC) or nitric oxide synthase (NOS) inhibition. Diazoxide 0-9 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 72-75 11313375-6 2001 The immunocomplex kinase assay indicated that IkappaB kinase activity stimulated by LPS was inhibited by ceramide, which concomitantly reduced the IkappaBalpha degradation caused by LPS within 1-6 h. In concert with the decreased cytosolic p65 protein level, LPS treatment resulted in rapid nuclear accumulation of NF-kappaB subunit p65 and its association with the cAMP-responsive element binding protein. Ceramides 105-113 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 240-243 11313375-6 2001 The immunocomplex kinase assay indicated that IkappaB kinase activity stimulated by LPS was inhibited by ceramide, which concomitantly reduced the IkappaBalpha degradation caused by LPS within 1-6 h. In concert with the decreased cytosolic p65 protein level, LPS treatment resulted in rapid nuclear accumulation of NF-kappaB subunit p65 and its association with the cAMP-responsive element binding protein. Ceramides 105-113 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 333-336 11179825-2 2001 In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of IkappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65. Capsaicin 45-54 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 300-303 11179825-2 2001 In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of IkappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65. Phorbol Esters 111-124 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 300-303 11701619-7 2001 Western blot confirmed the accumulation of p50 and p65 in nuclear extracts after anisomycin treatment. Anisomycin 81-91 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 11555406-0 2001 Antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappaB abrogate fulminant septic shock induced by S. typhimurium in mice. Phosphorothioate Oligonucleotides 10-43 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 11555406-6 2001 Treatment with specific antisense oligonucleotides against the p65 subunit of NF-kappaB 24 h before infection prevented the development of fulminant, lethal septic shock and was associated with a significant increase of survival. Oligonucleotides 34-50 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 63-66 11312646-11 2001 Further studies demonstrated a marked reduction in the nuclear levels of the stimulatory p65 subunit of NF-kappaB after propanil treatment, as measured by fluorescence confocal microscopy and Western blot analysis. Propanil 120-128 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 89-92 11312646-13 2001 Electrophoretic mobility gel shift assays showed decreased DNA binding of both p65/p50 heterodimers and p50/p50 homodimers to the kappaB3 site of the TNF-alpha promoter of propanil-treated cells. Propanil 172-180 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 79-82 11312646-14 2001 The marked reduction in nuclear p65/p50 NF-kappaB levels and diminished binding to the TNF-alpha promoter in propanil-treated cells are consistent with reduced TNF-alpha levels induced by LPS. Propanil 109-117 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 32-35 11360202-4 2001 Basal and calcium ionopore-induced GADD153 expression was more pronounced in fibroblasts obtained from mouse embryos lacking in p65 subunit of NF-kappaB compared to fibroblasts from wild type littermate embryos. Calcium 10-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-131 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. bu-11 23-28 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-133 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. bms2 29-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-133 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. 9,10-Dimethyl-1,2-benzanthracene 48-78 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-133 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. 9,10-Dimethyl-1,2-benzanthracene 80-84 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-133 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. Polycyclic Aromatic Hydrocarbons 100-103 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-133 11160867-9 2001 Finally, ectopic expression of Rel A or c-Rel rescued BU-11 cells from DMBA-induced apoptosis. bu-11 54-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-36 11160867-9 2001 Finally, ectopic expression of Rel A or c-Rel rescued BU-11 cells from DMBA-induced apoptosis. 9,10-Dimethyl-1,2-benzanthracene 71-75 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 31-36 11077049-7 2000 Curcumin blocked the disappearance of inhibitory kappaBalpha (IkappaBalpha) and p65 from the cytosolic fraction, and inhibited the phosphorylation of IkappaBalpha. Curcumin 0-8 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 80-83 10936515-6 2000 DEX treatment caused a significant reduction in nuclear c-rel, p65, and p50 protein contents, and these decreases were paralleled by the accumulation of cytoplasmic c-rel, p65, and p50. Dexamethasone 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 172-175 10692565-9 2000 Since these complexes are known to repress NF-kappaB-dependent gene transcription, our results delineate a second molecular mechanism, in addition to the recently found block of tumor necrosis factor-alpha-mediated p50/p65 activation, that may be responsible for the immunosuppresive effects of TCDD. Polychlorinated Dibenzodioxins 295-299 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 219-222 10747850-6 2000 The relA-transfected cells showed constitutive NF-kappaB DNA binding activity that could not be inhibited by curcumin and did not show nuclear condensation and DNA fragmentation upon treatment with curcumin. Curcumin 109-117 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 4-8 10747850-7 2000 When a super-repressor form of IkappaB-alpha (known to inhibit NF-kappaB) was transfected transiently into relA-transfected cells, the cells were no longer resistant to curcumin. Curcumin 169-177 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 107-111 10747850-0 2000 L-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosis. Curcumin 56-64 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 44-48 10698690-6 2000 Further analysis with purified recombinant NF-kappaB proteins revealed that both rp50 and rMBP-p65 (Rel A) proteins, but not rGST-IkappaB, could be poly(ADP-ribosyl)ated in vitro and that the modification resulted in a marked decrease in the DNA-binding activity of rMBP-p65, whereas a slight activation was observed in rp50. rmbp 90-94 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-98 10759763-0 2000 Therapeutic effect of intracolonically administered nuclear factor kappa B (p65) antisense oligonucleotide on mouse dextran sulphate sodium (DSS)-induced colitis. Oligonucleotides 91-106 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 76-79 10759763-0 2000 Therapeutic effect of intracolonically administered nuclear factor kappa B (p65) antisense oligonucleotide on mouse dextran sulphate sodium (DSS)-induced colitis. dextran sulphate sodium 116-139 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 76-79 10759763-0 2000 Therapeutic effect of intracolonically administered nuclear factor kappa B (p65) antisense oligonucleotide on mouse dextran sulphate sodium (DSS)-induced colitis. dss 141-144 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 76-79 10759763-3 2000 The effect of intracolonically administered NF-kappaB (p65) antisense phosphorothioate oligonucleotide was examined in mouse DSS-induced colitis using drinking water containing 5% DSS. Phosphorothioate Oligonucleotides 70-102 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 10759763-8 2000 Western blot analysis using homogenized rectal mucosa showed the decreased expression of NF-kappaB p65 in the antisense oligonucleotide-treated group, although it was increased in the colitis group. Oligonucleotides 120-135 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 99-102 10698690-6 2000 Further analysis with purified recombinant NF-kappaB proteins revealed that both rp50 and rMBP-p65 (Rel A) proteins, but not rGST-IkappaB, could be poly(ADP-ribosyl)ated in vitro and that the modification resulted in a marked decrease in the DNA-binding activity of rMBP-p65, whereas a slight activation was observed in rp50. rmbp 90-94 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 100-105 10698690-6 2000 Further analysis with purified recombinant NF-kappaB proteins revealed that both rp50 and rMBP-p65 (Rel A) proteins, but not rGST-IkappaB, could be poly(ADP-ribosyl)ated in vitro and that the modification resulted in a marked decrease in the DNA-binding activity of rMBP-p65, whereas a slight activation was observed in rp50. rmbp 90-94 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 271-274 10698690-7 2000 Poly(ADP-ribosyl)ated p65/NF-kappaB was detected in the cytosol of wild type L1210 cells by immunoblotting with anti-poly(ADP-ribose) and anti-p65 antibodies. poly(adp-ribosyl)ated 0-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 22-25 10698690-7 2000 Poly(ADP-ribosyl)ated p65/NF-kappaB was detected in the cytosol of wild type L1210 cells by immunoblotting with anti-poly(ADP-ribose) and anti-p65 antibodies. poly(adp-ribosyl)ated 0-21 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 143-146 10585435-2 1999 Increased expression of Bcl-x protein was observed in native and silica-exposed p50(-/-) macrophages in which the NF-kappaB p65-containing complex was predominantly induced. Silicon Dioxide 65-71 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 124-127 10723089-0 2000 Activation of a rel-A/CEBP-beta-related transcription factor heteromer by PGG-glucan in a murine monocytic cell line. poly-1-6-glucopyranosyl-1-3-glucopyranose glucan 74-84 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 16-21 10723089-3 2000 Previously we reported that PGG-Glucan treatment of mouse BMC2.3 macrophage cells activates a nuclear factor kappa-B-like (NF-kappaB) transcription factor complex containing subunit p65 (rel-A) attached to an unidentified cohort. poly-1-6-glucopyranosyl-1-3-glucopyranose glucan 28-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 182-185 10723089-3 2000 Previously we reported that PGG-Glucan treatment of mouse BMC2.3 macrophage cells activates a nuclear factor kappa-B-like (NF-kappaB) transcription factor complex containing subunit p65 (rel-A) attached to an unidentified cohort. poly-1-6-glucopyranosyl-1-3-glucopyranose glucan 28-38 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 187-192 10723089-10 2000 These data are consistent with a model whereby treatment of BMC2.3 cells with PGG-Glucan activates IkappaB-alpha via PKC and/or PTK pathways, permitting translocation of the rel-A/CEBP-beta heteromer complex to the nucleus and increases its DNA-binding affinity. poly-1-6-glucopyranosyl-1-3-glucopyranose glucan 78-88 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 174-179 11996111-7 2000 Differential nuclear translocation of p65-NF-kappaB in LY sublines is due to the more efficient antioxidant defence in LY-S than in LY-R cells. ly-s 119-123 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 38-51 9875227-4 1998 GSH inhibited the serine phosphorylation of I kappa B-alpha by TNF-alpha, leading to the downregulation of NF-kappa B-DNA binding activity followed by decreased expression of p65/p50 and I kappa B mRNAs. Glutathione 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 175-178 10432387-12 1999 ATRA also reduced nuclear levels of both subunits (p50 and p65) of NF-kappaB. Tretinoin 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 59-62 10378234-4 1999 Water maze results were correlated with in vivo electrophysiology and expression of the synaptic protein synaptotagmin (p65). Water 0-5 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 120-123 10435725-7 1999 Western blots revealed that, in me(v) whole cell lysates, there were reduced levels of RelA and RelB proteins and increased levels of p50 and c-Rel. Vanadium 16-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 87-91 10383397-4 1999 DZA inhibits the transcriptional activity of NF-kappaB through the hindrance of p65 (Rel-A) phosphorylation without reduction of its nuclear translocation and DNA binding activity. 3-deazaadenosine 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 80-83 10383397-4 1999 DZA inhibits the transcriptional activity of NF-kappaB through the hindrance of p65 (Rel-A) phosphorylation without reduction of its nuclear translocation and DNA binding activity. 3-deazaadenosine 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 85-90 10461759-3 1999 Hydrogen peroxide, phorbol ester and x-rays caused a marked translocation of p65-NF-kappaB in LY-R cells and a weak translocation in LY-S cells. Hydrogen Peroxide 0-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-90 10461759-3 1999 Hydrogen peroxide, phorbol ester and x-rays caused a marked translocation of p65-NF-kappaB in LY-R cells and a weak translocation in LY-S cells. Phorbol Esters 19-32 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 77-90 10461759-7 1999 We conclude that differential nuclear translocation of p65-NF-kappaB in LY sublines is not related to the lethal effect of the activating, damaging agent; rather it is due to the more efficient antioxidant defense in LY-S than in LY-R cells. ly-s 217-221 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-68 9886401-6 1999 In addition, ex vivo treatment of thymocyte single-cell suspension with dexamethasone accelerated p65/RelA down-regulation and cell death. Dexamethasone 72-85 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 98-101 9886401-6 1999 In addition, ex vivo treatment of thymocyte single-cell suspension with dexamethasone accelerated p65/RelA down-regulation and cell death. Dexamethasone 72-85 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-106 9862429-4 1998 PGE2 and iloprost also blocked disappearance of I kappaB-alpha from cytosolic fraction and nuclear translocation of NF-kappaB subunits p50 and p65. Dinoprostone 0-4 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 143-146 9862429-4 1998 PGE2 and iloprost also blocked disappearance of I kappaB-alpha from cytosolic fraction and nuclear translocation of NF-kappaB subunits p50 and p65. Iloprost 9-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 143-146 9535858-9 1998 When OCLs were pretreated with antisense oligodeoxynucleotides to p65 and p50 of NF-kappaB, the expression of respective mRNAs by OCLs was suppressed, and the IL-1-induced survival of OCLs was concomitantly inhibited. Oligodeoxyribonucleotides 41-62 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 66-69 9679644-5 1998 In addition, DEX treatment caused a significant reduction in nuclear c-rel, p65, and p50 protein contents, and these decreases were paralleled by the accumulation of cytoplasmic c-rel, p65, and p50. Dextromethorphan 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 76-79 9679644-5 1998 In addition, DEX treatment caused a significant reduction in nuclear c-rel, p65, and p50 protein contents, and these decreases were paralleled by the accumulation of cytoplasmic c-rel, p65, and p50. Dextromethorphan 13-16 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 185-188 9185577-0 1997 Formation of a G-tetrad and higher order structures correlates with biological activity of the RelA (NF-kappaB p65) "antisense" oligodeoxynucleotide. Oligodeoxyribonucleotides 128-148 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 95-99 9400829-8 1997 In contrast, PGG-Glucan increased the nuclear titer of p65, but apparently not p50, and did not induce cytokine mRNA production. poly-1-6-glucopyranosyl-1-3-glucopyranose glucan 13-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 9333018-4 1997 Cells inducibly expressing IRF-1 or IRF/RelA in response to doxycycline treatment displayed significantly reduced growth rates compared to control cells, and inhibition of cell growth correlated directly with the level of transgene expression. Doxycycline 60-71 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-44 9225039-6 1997 However, when mice were pretreated with cyclophosphamide, p65 primed for a strong DTH response to a level similar to that induced by p59 in mice either pretreated or not treated with cyclophosphamide. Cyclophosphamide 40-56 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 58-61 9405638-3 1997 Calcium-induced differentiation of these cells has been shown to be accompanied by the activation of tyrosine kinases and rapid phosphorylation of a 65-kDa GTPase-activating protein (GAP)-associated protein (GAP-A.p65). Calcium 0-7 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 214-217 9442381-4 1997 Specific downregulation of p65 by administration of antisense phosphorothioate oligonucleotides to mice with experimental colitis abrogated clinical and histological signs of mucosal inflammation. Phosphorothioate Oligonucleotides 62-95 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 27-30 9393872-10 1997 Moreover, inhibition of cellular growth was shown following treatment of p210BCR-ABL transformed DA1 cells by p65 antisense oligonucleotides. Oligonucleotides 124-140 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 110-113 9207123-5 1997 Degradation of IkappaBbeta and the translocation of the NF-kappaB (p50/RelA) into the nucleus, which occurred at 1.5 hr after anti-CD3 activation, were inhibited by lactacystin. lactacystin 165-176 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 71-75 9185577-0 1997 Formation of a G-tetrad and higher order structures correlates with biological activity of the RelA (NF-kappaB p65) "antisense" oligodeoxynucleotide. Oligodeoxyribonucleotides 128-148 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 111-114 9185577-1 1997 We have examined the behavior of the phosphorothioate antisense Rel A (NF-kappaB p65) oligodeoxynucleotide (oligo) and related molecules. Parathion 37-53 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-69 9185577-1 1997 We have examined the behavior of the phosphorothioate antisense Rel A (NF-kappaB p65) oligodeoxynucleotide (oligo) and related molecules. Parathion 37-53 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 81-84 9185577-1 1997 We have examined the behavior of the phosphorothioate antisense Rel A (NF-kappaB p65) oligodeoxynucleotide (oligo) and related molecules. Oligodeoxyribonucleotides 86-106 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-69 9185577-1 1997 We have examined the behavior of the phosphorothioate antisense Rel A (NF-kappaB p65) oligodeoxynucleotide (oligo) and related molecules. Oligodeoxyribonucleotides 86-106 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 81-84 9185577-1 1997 We have examined the behavior of the phosphorothioate antisense Rel A (NF-kappaB p65) oligodeoxynucleotide (oligo) and related molecules. Oligodeoxyribonucleotides 86-91 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-69 9185577-1 1997 We have examined the behavior of the phosphorothioate antisense Rel A (NF-kappaB p65) oligodeoxynucleotide (oligo) and related molecules. Oligodeoxyribonucleotides 86-91 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 81-84 9185577-10 1997 Thus, the parent phosphorothioate AS RelA molecule cannot be a Watson-Crick antisense agent. Parathion 17-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 37-41 9120401-7 1997 Furthermore, both T and B cells lacking RelA showed marked reduction in proliferative responses to stimulation with Con A, anti-CD3, anti-CD3 + anti-CD28, LPS, anti-IgM, and PMA + calcium ionophore. Tetradecanoylphorbol Acetate 174-177 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-44 9186501-4 1997 In fact, chloroquine enhances the signal-induced nuclear expression of NF-kappa B p50/p65 heterodimer by inhibiting the resynthesis of I kappa B alpha. Chloroquine 9-20 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 86-89 9120401-7 1997 Furthermore, both T and B cells lacking RelA showed marked reduction in proliferative responses to stimulation with Con A, anti-CD3, anti-CD3 + anti-CD28, LPS, anti-IgM, and PMA + calcium ionophore. Calcium 180-187 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-44 8687102-5 1996 Antisense phosphorothioate oligomers to relA but not NFKB1 caused a rapid inhibition of cell adhesion in diverse cell types. Parathion 10-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-44 8918464-6 1996 However, major tyrosine-phosphorylated proteins, p61 and p65, specifically associated with STK/RON in MEL/STK cells. Tyrosine 15-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 57-60 8918464-8 1996 Analyses of these mutants and in vitro association revealed that signalling proteins including p61 and p65 directly bound to the phosphotyrosines in the multifunctional docking site. Phosphotyrosine 129-145 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 103-106 8782457-3 1996 Local administration of p65 antisense phosphorothioate oligonucleotides abrogated clinical and histological signs of colitis and was more effective in treating TNBS-induced colitis than single or daily administration of glucocorticoids. Phosphorothioate Oligonucleotides 38-71 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 24-27 8687102-7 1996 Stable transfectants of a fibrosarcoma cell line expressing dexamethasone-inducible antisense RNA to relA also showed inhibition of in vitro growth and in vivo tumor development. Dexamethasone 60-73 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 101-105 7492966-12 1995 We show that binding of a p50/p65 complex to an NF-kappa B consensus sequence is enhanced by H2O2 treatment in NIH3T3 cells. Hydrogen Peroxide 93-97 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 30-33 7493996-6 1995 Nuclear proteins from cytokine-stimulated VSM cells which bind to an oligonucleotide containing this kappa B site are composed of p65 together with an unidentified protein of 50 kDa, which is not a known Rel family member. Oligonucleotides 69-84 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 130-133 7595063-5 1995 The farnesyltransferase inhibitor BZA-5B caused a dramatic decrease in p65 prenylation, suggesting that this protein may be modified by the C15 isoprenoid farnesyl. BZA 5B 34-40 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 71-74 7791759-7 1995 Upon stimulation of RelA-overexpressing thymocytes with phorbol 12-myristate 13-acetate and lectin (phytohemaglutinin), different kappa B-binding complexes, including RelA homodimers, were partially released from I kappa B alpha. Tetradecanoylphorbol Acetate 56-87 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 20-24 7791759-7 1995 Upon stimulation of RelA-overexpressing thymocytes with phorbol 12-myristate 13-acetate and lectin (phytohemaglutinin), different kappa B-binding complexes, including RelA homodimers, were partially released from I kappa B alpha. Tetradecanoylphorbol Acetate 56-87 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 167-171 7730629-9 1995 In addition, binding of the NF-kappa B (p50/p65) heterodimer to the NF-kappa B site was inhibited by cAMP. Cyclic AMP 101-105 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 44-47