PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
12479366-2	2002	Because flavopiridol, a novel flavanoid cyclin-cyclin-dependent kinase inhibitor, may function through Ras-dependent and/or -independent pathways, we hypothesized that treatment of breast cancer cells with inhibitors of Neu signaling and flavopiridol might synergize to inhibit proliferation.	alvocidib	8-20	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	220-223
12479366-12	2002	Flavopiridol and trastuzumab yield cytotoxic synergy in human breast cancer cells overexpressing Neu.	alvocidib	0-12	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	97-100
9050783-7	1997	However, in Pax6(Sey-Neu)/ Pax6(Sey-Neu) embryos, retinoic acid (RA) is not produced by the frontonasal mesenchyme, which normally provides local retinoid signals to the placode and forebrain.	Tretinoin	50-63	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	36-39
10428197-1	1999	The protease catalyzing the hydrolysis of the tripeptide fluorescence substrate, butoxycarbonyl-valine-proline-arginine-(7-amino-4-methylcoumarin) (Boc-Val-Pro-Arg-MCA) and the neu oncogenic protein are potentially useful biomarkers for human cancer prevention studies.	tripeptide K-26	46-56	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	177-180
10428197-1	1999	The protease catalyzing the hydrolysis of the tripeptide fluorescence substrate, butoxycarbonyl-valine-proline-arginine-(7-amino-4-methylcoumarin) (Boc-Val-Pro-Arg-MCA) and the neu oncogenic protein are potentially useful biomarkers for human cancer prevention studies.	butoxycarbonyl-valine	81-102	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	177-180
10428197-1	1999	The protease catalyzing the hydrolysis of the tripeptide fluorescence substrate, butoxycarbonyl-valine-proline-arginine-(7-amino-4-methylcoumarin) (Boc-Val-Pro-Arg-MCA) and the neu oncogenic protein are potentially useful biomarkers for human cancer prevention studies.	Proline	103-110	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	177-180
10428197-1	1999	The protease catalyzing the hydrolysis of the tripeptide fluorescence substrate, butoxycarbonyl-valine-proline-arginine-(7-amino-4-methylcoumarin) (Boc-Val-Pro-Arg-MCA) and the neu oncogenic protein are potentially useful biomarkers for human cancer prevention studies.	Arginine	111-119	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	177-180
10428197-1	1999	The protease catalyzing the hydrolysis of the tripeptide fluorescence substrate, butoxycarbonyl-valine-proline-arginine-(7-amino-4-methylcoumarin) (Boc-Val-Pro-Arg-MCA) and the neu oncogenic protein are potentially useful biomarkers for human cancer prevention studies.	7-amino-4-methylcoumarin	121-145	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	177-180
10428197-1	1999	The protease catalyzing the hydrolysis of the tripeptide fluorescence substrate, butoxycarbonyl-valine-proline-arginine-(7-amino-4-methylcoumarin) (Boc-Val-Pro-Arg-MCA) and the neu oncogenic protein are potentially useful biomarkers for human cancer prevention studies.	Proline	156-160	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	177-180
10428197-3	1999	The results demonstrate that changes in the protease activity in oral mucosal cells after BBIC treatment correlated with the changes in the neu protein levels in oral mucosal cells (r = 0.726, P < 0.001) and serum (r = 0.675, P < 0.001), suggesting that the Boc-Val-Pro-Arg-MCA hydrolyzing activity can be as useful as neu oncogene expression as a cancer biomarker.	bbic	90-94	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	140-143
10428197-3	1999	The results demonstrate that changes in the protease activity in oral mucosal cells after BBIC treatment correlated with the changes in the neu protein levels in oral mucosal cells (r = 0.726, P < 0.001) and serum (r = 0.675, P < 0.001), suggesting that the Boc-Val-Pro-Arg-MCA hydrolyzing activity can be as useful as neu oncogene expression as a cancer biomarker.	bbic	90-94	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	325-328
10428197-4	1999	In the 25 patients enrolled in the study, the level of neu protein in oral mucosal cells correlated with the serum neu protein concentration in the patients before BBIC treatment (r = 0.645, P < 0.001).	bbic	164-168	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	55-58
10428197-6	1999	By inhibiting the cleavage of neu protein on the cell surface, BBI could prevent malignant and premalignant cells expressing high levels of neu protein antigen from escaping host immunological surveillance control.	Amiodarone	63-66	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	30-33
10428197-6	1999	By inhibiting the cleavage of neu protein on the cell surface, BBI could prevent malignant and premalignant cells expressing high levels of neu protein antigen from escaping host immunological surveillance control.	Amiodarone	63-66	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	140-143
9399668-1	1997	A formulation of metoclopramide (MCA) conformationally altered by neutralization of pH (nMCA, Neu-Sensamide) has been shown to have the same efficacy of enhancing the cytotoxicity of a single dose of 1 Gy radiation as acidic formulations (e.g., Primperan, Sensamide) in a human lung adenocarcinoma (H2981) xenografted into SCID mice.	Metoclopramide	17-31	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	94-97
9399668-1	1997	A formulation of metoclopramide (MCA) conformationally altered by neutralization of pH (nMCA, Neu-Sensamide) has been shown to have the same efficacy of enhancing the cytotoxicity of a single dose of 1 Gy radiation as acidic formulations (e.g., Primperan, Sensamide) in a human lung adenocarcinoma (H2981) xenografted into SCID mice.	Metoclopramide	33-36	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	94-97
9399668-1	1997	A formulation of metoclopramide (MCA) conformationally altered by neutralization of pH (nMCA, Neu-Sensamide) has been shown to have the same efficacy of enhancing the cytotoxicity of a single dose of 1 Gy radiation as acidic formulations (e.g., Primperan, Sensamide) in a human lung adenocarcinoma (H2981) xenografted into SCID mice.	sensamide	98-107	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	94-97
9108689-1	1997	Conformations of oligo- and poly-(alpha (2-->8)-D-Neu pNAc) (colominic acid) and its derivatives were studied by circular dichroism (CD) spectroscopy and viscometry to understand the molecular basis of their unusual antigenic properties.	colominic acid	64-78	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	53-56
9089424-0	1997	Comparative central nervous system effects and pharmacokinetics of neu-metoclopramide and metoclopramide in healthy volunteers.	Metoclopramide	71-85	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	67-70
9089424-3	1997	Neu-metoclopramide (Neu-Sensamide), a novel, concentrated, phosphate-buffered, pH-adjusted (pH = 6.5-7.0) formulation of metoclopramide, has been shown to have an improved side-effect profile in animal studies.	Phosphates	59-68	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	0-3
9089424-3	1997	Neu-metoclopramide (Neu-Sensamide), a novel, concentrated, phosphate-buffered, pH-adjusted (pH = 6.5-7.0) formulation of metoclopramide, has been shown to have an improved side-effect profile in animal studies.	Phosphates	59-68	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	20-23
9089424-3	1997	Neu-metoclopramide (Neu-Sensamide), a novel, concentrated, phosphate-buffered, pH-adjusted (pH = 6.5-7.0) formulation of metoclopramide, has been shown to have an improved side-effect profile in animal studies.	Metoclopramide	4-18	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	0-3
9089424-3	1997	Neu-metoclopramide (Neu-Sensamide), a novel, concentrated, phosphate-buffered, pH-adjusted (pH = 6.5-7.0) formulation of metoclopramide, has been shown to have an improved side-effect profile in animal studies.	Metoclopramide	4-18	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	20-23
9089424-4	1997	The present double-blind, four-way crossover study compared the central nervous system effects and pharmacokinetics of neu-metoclopramide (intravenously and intramuscularly at 1.8 mg/kg) with intravenous metoclopramide and intramuscular placebo in 19 healthy male volunteers.	Metoclopramide	123-137	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	119-122
9089424-9	1997	It may be speculated, therefore, that the molecular conformational changes inherent to neu-metoclopramide result in a reduced side-effect profile compared with conventional metoclopramide formulations.	Metoclopramide	91-105	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	87-90
9082708-0	1996	[Life threatening anaphylaxis after repeated cisplatin administration: case report and neu therapy concepts].	Cisplatin	45-54	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	87-90
9208905-1	1997	Radiation induced cytotoxicity was potentiated by neutralized metoclopramide (nMCA; Neu-Sensamide, Oxigene Inc) when a human lung adenocarcinoma (H2981) transplanted into scid mice and an adeno-type 12 virus induced mouse sarcoma (A12B3) inoculated into CBA mice were exposed in vivo to low dose radiation at single doses of 1 and 2 Gy respectively.	Metoclopramide	62-76	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	84-87
1683842-4	1991	With the use of the polymerase chain reaction and allele-specific oligonucleotide hybridization, DNA isolated from individual myotubes was analyzed for the presence of a T----A transversion mutation at nucleotide 2012 of the neu gene, which is diagnostic of EtNU-induced rat schwannomas.	etnu	258-262	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	225-228
7670144-1	1995	A neutralized formulation (Neu-Sensamide) of metoclopramide (MCA) has been shown to possess reduced sedative side effects compared with the conventional acidic formulations (Primperan).	Metoclopramide	45-59	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	27-30
7670144-1	1995	A neutralized formulation (Neu-Sensamide) of metoclopramide (MCA) has been shown to possess reduced sedative side effects compared with the conventional acidic formulations (Primperan).	Metoclopramide	61-64	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	27-30
8368065-1	1993	Heavy metal intoxication of newborn infants fed with "Ba-Pao-Neu-Hwang-San" has been reported every year by many hospitals in Taiwan.	Metals	6-11	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	61-64
32189255-0	2020	Neu: Fentanyl Aristo  Buccal-tabletten zur Behandlung von Durchbruchschmerzen.	Fentanyl	5-13	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	0-3
3524305-3	1986	Important events were the first demonstration of Koller"s local anaesthesia in the eye in 1884, the first intubation for anaesthesia in Heidelberg, performed by F. Kuhn of Kassel and the development by M. Neu of a rotameter apparatus for nitrous oxide/oxygen anaesthesia in 1910.	Nitrous Oxide	238-251	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	205-208
3524305-3	1986	Important events were the first demonstration of Koller"s local anaesthesia in the eye in 1884, the first intubation for anaesthesia in Heidelberg, performed by F. Kuhn of Kassel and the development by M. Neu of a rotameter apparatus for nitrous oxide/oxygen anaesthesia in 1910.	Oxygen	252-258	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	205-208
6584083-2	1983	Chemically, the antigen was identified as ganglioside GD2 [Gal NAc beta 1----4 (Neu Ac alpha 2----8 Neu Ac alpha 2---3) Gal beta 1----4 Glc----ceramide].	Gangliosides	42-53	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	80-83
6584083-2	1983	Chemically, the antigen was identified as ganglioside GD2 [Gal NAc beta 1----4 (Neu Ac alpha 2----8 Neu Ac alpha 2---3) Gal beta 1----4 Glc----ceramide].	Gangliosides	42-53	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	100-103
6584083-2	1983	Chemically, the antigen was identified as ganglioside GD2 [Gal NAc beta 1----4 (Neu Ac alpha 2----8 Neu Ac alpha 2---3) Gal beta 1----4 Glc----ceramide].	ganglioside, GD2	54-57	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	80-83
6786888-14	1981	The second O-glycosidically-linked chain was a disialylated tetrasaccharide with the structure, Neu(alpha 2 leads to 3)Gal(beta 1 leads to 3)[NeuAc(alpha 2 leads to 6)GalNAc leads to Ser.	tetrasaccharide	60-75	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	96-99
6786888-14	1981	The second O-glycosidically-linked chain was a disialylated tetrasaccharide with the structure, Neu(alpha 2 leads to 3)Gal(beta 1 leads to 3)[NeuAc(alpha 2 leads to 6)GalNAc leads to Ser.	cyclohexenoesculetin-beta-galactoside	119-122	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	96-99
6786888-14	1981	The second O-glycosidically-linked chain was a disialylated tetrasaccharide with the structure, Neu(alpha 2 leads to 3)Gal(beta 1 leads to 3)[NeuAc(alpha 2 leads to 6)GalNAc leads to Ser.	N-Acetylneuraminic Acid	142-147	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	96-99
6786888-14	1981	The second O-glycosidically-linked chain was a disialylated tetrasaccharide with the structure, Neu(alpha 2 leads to 3)Gal(beta 1 leads to 3)[NeuAc(alpha 2 leads to 6)GalNAc leads to Ser.	N-acetylgalactosaminuronic acid	167-173	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	96-99
6786888-14	1981	The second O-glycosidically-linked chain was a disialylated tetrasaccharide with the structure, Neu(alpha 2 leads to 3)Gal(beta 1 leads to 3)[NeuAc(alpha 2 leads to 6)GalNAc leads to Ser.	Serine	183-186	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	96-99
4916696-0	1970	[Recollections of a sick prisoner of the Neu Sustrum and Gusen concentration camp].	Cyclic AMP	77-81	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	41-44
32701275-0	2020	The Role of MLCT states in the Franck-Condon region of neu-tral, heteroleptic Cu(I)-4H-imidazolate complexes: A Spectro-scopic and Theoretical Study.	cu(i)-4h-imidazolate	78-98	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	55-58
1970152-5	1990	We also used NIH3T3 cells transfected with either a normal or a mutated human neu gene, encoding a protein with a valine to glutamic acid substitution in the transmembrane domain.	Valine	114-120	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	78-81
1970152-5	1990	We also used NIH3T3 cells transfected with either a normal or a mutated human neu gene, encoding a protein with a valine to glutamic acid substitution in the transmembrane domain.	Glutamic Acid	124-137	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	78-81
1970152-7	1990	In contrast, the antibodies induced 50-65% down-modulation in NIH3T3 cells expressing the mutated human neu protein and could inhibit these cells to form colonies in soft agar.	Agar	171-175	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	104-107
1982565-1	1990	The distribution of the neu protein has been studied with two monoclonal antibodies in a post-embedding immunogold method on glycolmethacrylate sections.	hydroxyethyl methacrylate	125-143	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	24-27
35408676-0	2022	Bisphenol A Impairs Lipid Remodeling Accompanying Cell Differentiation in the Oligodendroglial Cell Line Oli-Neu.	bis(4-hydroxyphenyl)sulfone	0-9	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	109-112
35408676-7	2022	In unexposed cells, significant changes occurred in lipid distribution during Oli-neu differentiation, including an increase in characteristic myelin lipids, sulfatides, and ethanolamine plasmalogens, and a marked remodeling of phospholipid subclasses and fatty acid contents.	Sulfoglycosphingolipids	158-168	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	82-85
35408676-7	2022	In unexposed cells, significant changes occurred in lipid distribution during Oli-neu differentiation, including an increase in characteristic myelin lipids, sulfatides, and ethanolamine plasmalogens, and a marked remodeling of phospholipid subclasses and fatty acid contents.	Ethanolamine	174-186	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	82-85
35408676-7	2022	In unexposed cells, significant changes occurred in lipid distribution during Oli-neu differentiation, including an increase in characteristic myelin lipids, sulfatides, and ethanolamine plasmalogens, and a marked remodeling of phospholipid subclasses and fatty acid contents.	Fatty Acids	256-266	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	82-85
2840027-9	1988	With a thin-layer chromatography method, the biochemical determinants recognized by the cold autoantibodies were defined as glycolipids containing Neu Ac alpha 2-3Gal beta 1-4Glc sequences.	Glycolipids	124-135	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	147-150
4066681-7	1985	Mucin species II contained these same oligosaccharides as well as four additional acidic structures, notably a disaccharide Neu alpha (2-6)GalNAc-ol and a hexasaccharide Gal beta (1-4)GlcNAc beta (1-3)Gal beta (1-4)GlcNAc beta (1-3) (NeuAc alpha (2-6))-GalNAc-ol, not identified in any other mucin species.	Disaccharides	111-123	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	124-127
6689265-3	1983	The structure of this O-glycosidically linked glycan was determined to be: Neu Ac alpha (2 leads to 3) Gal beta (1 leads to 3) GaINAc alpha (1 leads to 0) Ser (or Thr).	Polysaccharides	46-52	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	75-78
6689265-3	1983	The structure of this O-glycosidically linked glycan was determined to be: Neu Ac alpha (2 leads to 3) Gal beta (1 leads to 3) GaINAc alpha (1 leads to 0) Ser (or Thr).	Serine	155-158	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	75-78
6584083-2	1983	Chemically, the antigen was identified as ganglioside GD2 [Gal NAc beta 1----4 (Neu Ac alpha 2----8 Neu Ac alpha 2---3) Gal beta 1----4 Glc----ceramide].	ganglioside, GD2	54-57	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	100-103
6584083-2	1983	Chemically, the antigen was identified as ganglioside GD2 [Gal NAc beta 1----4 (Neu Ac alpha 2----8 Neu Ac alpha 2---3) Gal beta 1----4 Glc----ceramide].	cyclohexenoesculetin-beta-galactoside	59-62	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	80-83
6584083-2	1983	Chemically, the antigen was identified as ganglioside GD2 [Gal NAc beta 1----4 (Neu Ac alpha 2----8 Neu Ac alpha 2---3) Gal beta 1----4 Glc----ceramide].	nac beta 1----4	63-78	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	80-83
6584083-2	1983	Chemically, the antigen was identified as ganglioside GD2 [Gal NAc beta 1----4 (Neu Ac alpha 2----8 Neu Ac alpha 2---3) Gal beta 1----4 Glc----ceramide].	nac beta 1----4	63-78	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	100-103
6584083-2	1983	Chemically, the antigen was identified as ganglioside GD2 [Gal NAc beta 1----4 (Neu Ac alpha 2----8 Neu Ac alpha 2---3) Gal beta 1----4 Glc----ceramide].	Actinium	64-66	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	80-83
6584083-2	1983	Chemically, the antigen was identified as ganglioside GD2 [Gal NAc beta 1----4 (Neu Ac alpha 2----8 Neu Ac alpha 2---3) Gal beta 1----4 Glc----ceramide].	gal beta 1----4 glc----ceramide	120-151	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	80-83
989292-1	1976	Three decomposition products of Morazone (ingredient of the pharmaceutical preparation Rosimon-Neu) were observed following heat treatment in acid medium (hydrochloric or tartaric acid).	morazone	32-40	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	95-98
989292-1	1976	Three decomposition products of Morazone (ingredient of the pharmaceutical preparation Rosimon-Neu) were observed following heat treatment in acid medium (hydrochloric or tartaric acid).	acid medium	142-153	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	95-98
989292-1	1976	Three decomposition products of Morazone (ingredient of the pharmaceutical preparation Rosimon-Neu) were observed following heat treatment in acid medium (hydrochloric or tartaric acid).	hydrochloric	155-167	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	95-98
989292-1	1976	Three decomposition products of Morazone (ingredient of the pharmaceutical preparation Rosimon-Neu) were observed following heat treatment in acid medium (hydrochloric or tartaric acid).	tartaric acid	171-184	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	95-98
23884408-6	2013	Treatment with NAA or NAAG significantly increased GSC growth and suppressed differentiation of Oli-Neu cells and proneural GSCs.	N-acetylaspartate	15-18	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	100-103
31667116-4	2019	The BTM-NEU can test an ISO-standardized cruciform specimen as the BTM-std and its performance is equivalent to that of the BTM-std.	Isoproterenol	24-27	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	8-11
31322250-4	2019	Orally administered GLG-302 and its trizma salt derivative reduced mammary cancer incidence, multiplicity, and tumor weights in female MMTV/Neu mice, and GLG-302 reduced tumor multiplicity and weights in female DMBA-treated rats.	ALPHA-D-GLUCOPYRANOSYL-2-CARBOXYLIC ACID AMIDE	20-23	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	140-143
31068605-2	2019	Using a yeast two-hybrid screen, we have identified a cGMP-hydrolysing phosphodiesterase, PDE9A, as a novel interactor and substrate of Neuralized E3 ubiquitin protein ligase 1 (NEURL1).	Cyclic GMP	54-58	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	136-176
31068605-2	2019	Using a yeast two-hybrid screen, we have identified a cGMP-hydrolysing phosphodiesterase, PDE9A, as a novel interactor and substrate of Neuralized E3 ubiquitin protein ligase 1 (NEURL1).	Cyclic GMP	54-58	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	178-184
31068605-4	2019	We also demonstrate that NEURL1 can promote polyubiquitination of PDE9A that leads to its proteasome-mediated degradation mainly via lysine residue K27 of ubiquitin.	Lysine	133-139	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	25-31
27159951-7	2016	These results show that hemantane has a greater neu-roprotective potential in comparison to amantadine.	hemantane	24-33	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	48-51
23884408-6	2013	Treatment with NAA or NAAG significantly increased GSC growth and suppressed differentiation of Oli-Neu cells and proneural GSCs.	isospaglumic acid	22-26	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	100-103
24455842-1	2013	Publication presents the short history of camp hospital which was organised in 1943 Nazi concentration camp Neu-Dachs in Jaworzno.	Cyclic AMP	42-46	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	108-111
23268106-1	2013	Neu2000 [2-hydroxy-5-(2,3,5,6-tetrafluoro-4 trifluoromethylbenzylamino) benzoic acid] is a dual-acting neuroprotective agent that functions both as a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist and a free radical scavenger.	2-hydroxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)benzoic acid	9-84	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	0-3
23268106-1	2013	Neu2000 [2-hydroxy-5-(2,3,5,6-tetrafluoro-4 trifluoromethylbenzylamino) benzoic acid] is a dual-acting neuroprotective agent that functions both as a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist and a free radical scavenger.	N-Methylaspartate	165-185	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	0-3
24455842-1	2013	Publication presents the short history of camp hospital which was organised in 1943 Nazi concentration camp Neu-Dachs in Jaworzno.	Cyclic AMP	103-107	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	108-111
20191354-4	2010	Staurosporine (160 nM) and H-7 (200 nM) downregulated the cellular NF-kappaB activation up to 20 and 60% compared to the NF-kappaB activity that was upregulated by NMU (5 microM) and NEU (5 microM), respectively.	Staurosporine	0-13	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	183-186
20191354-7	2010	The relative amount of I-kappaBalpha phosphorylation (serines-32 and -36) determined using the cellular activation of signaling ELISA assay method showed that NMU (5 microM) and NEU (5 microM) increased the amount of I-kappaBalpha phosphorylation up to 17 and 10% compared to the control, respectively.	Serine	54-61	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	178-181
17106444-0	2007	Marked prevention of ischemic brain injury by Neu2000, an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine.	N-Methylaspartate	58-62	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	46-49
18077452-0	2008	Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1.	Nitrogen	0-1	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	19-25
17604887-2	2007	The integrated perspective needed to quantify the net effect of N on greenhouse-gas balance is being addressed by the NitroEurope Integrated Project (NEU).	Nitrogen	64-65	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	150-153
19746216-7	2007	For the treatment of the human transfectant cells with chemical carcinogens, all-trans retinoic acid (5 mM) and 13-cis retinoic acid (5 mM) downregulated the cellular NF-kappaB activation up to 83% and 85% compared to the NF-kappaB activity that was upregulated by NMU (5microM) and NEU (5microM), respectively.	Tretinoin	87-100	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	283-286
19746216-7	2007	For the treatment of the human transfectant cells with chemical carcinogens, all-trans retinoic acid (5 mM) and 13-cis retinoic acid (5 mM) downregulated the cellular NF-kappaB activation up to 83% and 85% compared to the NF-kappaB activity that was upregulated by NMU (5microM) and NEU (5microM), respectively.	Isotretinoin	112-132	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	283-286
17106444-0	2007	Marked prevention of ischemic brain injury by Neu2000, an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine.	Aspirin	103-110	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	46-49
17106444-0	2007	Marked prevention of ischemic brain injury by Neu2000, an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine.	Sulfasalazine	115-128	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	46-49
15051716-1	2004	We have investigated peptides corresponding to the complete transmembrane region of both proto-oncogenic (Val(664)) and mutant (Glu(664)) forms of the receptor Neu in detergent micelles by NMR and CD spectroscopy.	Glutamic Acid	128-131	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	160-163
19746216-0	2007	The chemopreventive effect of retinoids on cellular NF-kappaB activity induced by NMU and NEU in human malignant keratinocytes.	Retinoids	30-39	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	90-93
19746216-1	2007	PURPOSE: Retinoids have been shown to be effective in suppressing tumor development when chemical carcinogens such as N-nitroso-N-methylurea (NMU) and N-nitroso-N-ethylurea (NEU) were used to induce mammary tumors in a variety of animal models.	Retinoids	9-18	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	151-172
19746216-1	2007	PURPOSE: Retinoids have been shown to be effective in suppressing tumor development when chemical carcinogens such as N-nitroso-N-methylurea (NMU) and N-nitroso-N-ethylurea (NEU) were used to induce mammary tumors in a variety of animal models.	Retinoids	9-18	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	174-177
19746216-1	2007	PURPOSE: Retinoids have been shown to be effective in suppressing tumor development when chemical carcinogens such as N-nitroso-N-methylurea (NMU) and N-nitroso-N-ethylurea (NEU) were used to induce mammary tumors in a variety of animal models.	Methylnitrosourea	142-145	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	174-177
19746216-3	2007	The purpose of this study was to determine the implications of NF-kappaB activation on the chemopreventive role of retinoids and their effect on cellular NF-kappaB activity that"s induced by known alkylating chemical carcinogens such as NMU and NEU in human transfectant squamous cell carcinoma (SCC-13) cells.	Retinoids	115-124	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	245-248
19746216-3	2007	The purpose of this study was to determine the implications of NF-kappaB activation on the chemopreventive role of retinoids and their effect on cellular NF-kappaB activity that"s induced by known alkylating chemical carcinogens such as NMU and NEU in human transfectant squamous cell carcinoma (SCC-13) cells.	Methylnitrosourea	237-240	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	245-248
16047371-5	2005	Despite the lack of evidence for progenitor cell migration toward the postischemic striatum or prefrontal neocortex, a small but sustained proportion of BrdU-labeled cells expressed features of postmitotic neurons (positive for the protein Neu N and the transcription factors Tbr 1 and Islet 1) in these two regions for at least 79 days after ischemia.	Bromodeoxyuridine	153-157	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	240-243
16076030-0	2005	Generation of anti-Neu-glycolyl-ganglioside antibodies by immunization with an anti-idiotype monoclonal antibody: A self versus non-self-matter.	glycolyl-ganglioside	23-43	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	19-22
16076030-1	2005	We have previously generated a murine anti-idiotype (Ab2) monoclonal antibody (mAb) to a murine Ab1 mAb, named P3, which selectively binds Neu-glycolyl (NeuGc)-sialic acid on several monosialo- and disialogangliosides, and also reacts with sulfatides and antigens expressed in human melanoma and breast tumors.	monosialo- and disialogangliosides	183-217	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	139-142
16076030-1	2005	We have previously generated a murine anti-idiotype (Ab2) monoclonal antibody (mAb) to a murine Ab1 mAb, named P3, which selectively binds Neu-glycolyl (NeuGc)-sialic acid on several monosialo- and disialogangliosides, and also reacts with sulfatides and antigens expressed in human melanoma and breast tumors.	Sulfoglycosphingolipids	240-250	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	139-142
15197512-7	2004	If the energy cost of such water penetration is significant enough, this may be a factor in the enhanced dimerization affinity of Glu664-mutant Neu.	Water	27-32	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	144-147