PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 16313356-5 2005 In contrast, U-75302 increased zymosan-stimulated release of IL-12 p40 by approximately 23%. U 75302 13-20 interleukin 12b Mus musculus 67-70 16313356-5 2005 In contrast, U-75302 increased zymosan-stimulated release of IL-12 p40 by approximately 23%. Zymosan 31-38 interleukin 12b Mus musculus 67-70 16313356-10 2005 Agonists of the nuclear LTB(4) receptor peroxisome proliferator-activated receptor-alpha, 8(S)-hydroxyeicosatetraenoic acid and 5,8,11,14-eicosatetraynoic acid, inhibited release of both IL-12 p40 and IL-10. alpha, 8(s)-hydroxyeicosatetraenoic acid 83-123 interleukin 12b Mus musculus 193-196 16313356-10 2005 Agonists of the nuclear LTB(4) receptor peroxisome proliferator-activated receptor-alpha, 8(S)-hydroxyeicosatetraenoic acid and 5,8,11,14-eicosatetraynoic acid, inhibited release of both IL-12 p40 and IL-10. 5,8,11,14-Eicosatetraynoic Acid 128-159 interleukin 12b Mus musculus 193-196 16114990-3 2005 Quantitatively, BB gelatin stimulated adherent PEC of C3H/HeN mice to secrete interleukin (IL)-12 (+p40), TNF-alpha, and IL-6 but not IL-1beta, IL-2, IL-10, and IFN-gamma. boeravinone B 16-18 interleukin 12b Mus musculus 100-103 16299287-8 2005 The production of IL-12p40 in morphine withdrawal mice was also suppressed. Morphine 30-38 interleukin 12b Mus musculus 18-26 16186163-2 2005 Using an in vitro model of macrophage activation, we show that schistosome larvae possess molecules that directly stimulate both thioglycollate-elicited macrophages (tM) and IFNgamma-activated tM in vitro to produce several cytokines including IL-6, IL-12p40 and IL-10. Thioglycolates 129-143 interleukin 12b Mus musculus 250-258 16148144-4 2005 In addition to DC, HKBA can elicit IL-12p40 secretion from macrophages, in which case the effect is wholly MyD88 dependent but only partially TLR9 dependent. hkba 19-23 interleukin 12b Mus musculus 35-43 15997465-5 2005 KC from gamma-spz-immune-challenged mice up-regulated class I and costimulatory molecules and produced elevated IL-12p40, relative to naive KC. gamma-spz 8-17 interleukin 12b Mus musculus 112-120 15997465-6 2005 In contrast, KC from naive mice exposed to infectious spz down-modulated class I and IL-12p40 was undetectable. saperconazole 54-57 interleukin 12b Mus musculus 85-93 15720441-6 2005 ABH also had a significant impact on peptidoglycan-induced or CpG oligodeoxynucleotide-induced IL-12p40 production in DCs. Oligodeoxyribonucleotides 66-86 interleukin 12b Mus musculus 95-103 15939587-4 2005 IFN-gamma and IL-12p40 levels were significantly reduced by 1,25-dihydroxyvitamin D3 in infected mice sera indicating an inhibition of Th-1-type cytokines. Calcitriol 60-84 interleukin 12b Mus musculus 14-22 15821753-3 2005 2 JWH-133 evoked a concentration-related inhibition (10 nM-5 microM) of LPS/IFN-gamma induced IL-12p40 release. 1,1-dimethylbutyl-1-deoxy-Delta(9)-THC 2-9 interleukin 12b Mus musculus 94-102 15746247-1 2005 Inhibitory oligonucleotides (IN-ODN) differing from stimulatory CpG ODN (ST-ODN) by as few as two bases can block ST-ODN-induced proliferation, apoptosis protection and IL-6 secretion in B lymphocytes and the production of IL-12p40 by non-B cells. Oligonucleotides 11-27 interleukin 12b Mus musculus 223-231 15742155-3 2005 Spleen cells from lupus prone Palmerston North (PN) mice produce several fold less IL-12p40 than controls in response to CpG-oligodeoxynucleotides (ODNs). CPG-oligonucleotide 121-146 interleukin 12b Mus musculus 83-91 15735429-6 2005 Treatment with Ro significantly decreased expression of interferon gamma (IFNgamma), interleukin 17 (IL-17), tumor necrosis factor alpha, and the inducible nitric oxide synthase mRNA in the colon, whereas expression of IL-12p40 was unchanged. Rosiglitazone 15-17 interleukin 12b Mus musculus 219-227 15626475-5 2005 SB203580 significantly increased TMEV-induced p19 but decreased p40 expression. SB 203580 0-8 interleukin 12b Mus musculus 64-67 15626475-6 2005 In contrast, U0126 decreased p19 and increased TMEV-induced p40 and IFN-beta expression. U 0126 13-18 interleukin 12b Mus musculus 60-63 15531295-4 2004 We also found that piperine could reduce the expression of IL-1beta, IL-6, TNF-alpha, GM-CSF and IL-12p40 genes. piperine 19-27 interleukin 12b Mus musculus 97-105 15340218-0 2004 Effect of various catechins on the IL-12p40 production by murine peritoneal macrophages and a macrophage cell line, J774.1. Catechin 18-27 interleukin 12b Mus musculus 35-43 15340218-3 2004 We investigated the effect of catechins on IL-12p40 production in murine macrophages induced by bacterial lipopolysaccharide (LPS). Catechin 30-39 interleukin 12b Mus musculus 43-51 15340218-4 2004 Pretreatment with several catechins at doses of 0.3-30 microM suppressed IL-12 p40 production by murine peritoneal exudate cells (PEC) and J774.1 cells in a dose-dependent manner. Catechin 26-35 interleukin 12b Mus musculus 73-82 15294990-5 2004 EtOH decreased IL-6 and IL-12 (p40), but did not significantly affect IL-10 in peritoneal lavage fluid or in lysates of peritoneal cells. Ethanol 0-4 interleukin 12b Mus musculus 31-34 15313929-7 2004 In vivo stimulation of mice with pIC and CpG-ODN demonstrated synergy for serum IL-6 and IL-12p40 levels that correlated with an enhanced antitumor effect against established B16-F10 experimental pulmonary metastases. Poly I-C 33-36 interleukin 12b Mus musculus 89-97 14679201-4 2004 As a consequence, the NO donor S-nitroso-N-acetylpenicillamine (SNAP) inhibits lipopolysaccharide (LPS)-induced IL-12 p40 mRNA expression, protein production, and promoter activity in murine macrophages, dendritic cells, and the murine macrophage cell line RAW 264.7. S-Nitroso-N-Acetylpenicillamine 31-62 interleukin 12b Mus musculus 112-121 15123779-5 2004 However, PGE2 produced by tumors potently inhibits the production of endogenous IL-12 at the level of protein secretion, mRNA synthesis, and transcription of the constituent p40 and p35 genes. Dinoprostone 9-13 interleukin 12b Mus musculus 174-177 15123779-7 2004 Moreover, PGE2-mediated inhibition of IL-12 production requires the functional cooperation of AP-1 and AP-1 strongly suppresses IL-12 p40 transcription. Dinoprostone 10-14 interleukin 12b Mus musculus 134-137 15187114-3 2004 We report in this work that, unexpectedly, simvastatin enhances LPS-induced IL-12p40 production by murine macrophages, and that it does so by activating the IL-12p40 promoter. Simvastatin 43-54 interleukin 12b Mus musculus 76-84 15187114-3 2004 We report in this work that, unexpectedly, simvastatin enhances LPS-induced IL-12p40 production by murine macrophages, and that it does so by activating the IL-12p40 promoter. Simvastatin 43-54 interleukin 12b Mus musculus 157-165 15274362-6 2004 CY significantly enhanced IL-12 (p40) mRNA compared to that by ONO-4007 alone. Cyclophosphamide 0-2 interleukin 12b Mus musculus 33-36 15340218-9 2004 These results suggest that gallate-containing catechins, particularly EGCG, inhibits LPS-induced IL-12p40 production in murine macrophages by inhibiting p38 MAPK while enhancing p44/p42 ERK, leading to the inhibition of IkappaBalpha degradation and NF-kappaB activation. Gallic acid 27-34 interleukin 12b Mus musculus 97-105 15340218-9 2004 These results suggest that gallate-containing catechins, particularly EGCG, inhibits LPS-induced IL-12p40 production in murine macrophages by inhibiting p38 MAPK while enhancing p44/p42 ERK, leading to the inhibition of IkappaBalpha degradation and NF-kappaB activation. Catechin 46-55 interleukin 12b Mus musculus 97-105 15340218-9 2004 These results suggest that gallate-containing catechins, particularly EGCG, inhibits LPS-induced IL-12p40 production in murine macrophages by inhibiting p38 MAPK while enhancing p44/p42 ERK, leading to the inhibition of IkappaBalpha degradation and NF-kappaB activation. epigallocatechin gallate 70-74 interleukin 12b Mus musculus 97-105 15187114-6 2004 Simvastatin prevents LPS-induced c-Fos expression, thereby relieving the inhibitory effect of c-Fos on the IL-12p40 promoter. Simvastatin 0-11 interleukin 12b Mus musculus 107-115 15187114-7 2004 Concomitantly, simvastatin induces the phosphorylation of c-Jun by the c-Jun N-terminal kinase, resulting in c-Jun-dependent activation of the IL-12p40 promoter. Simvastatin 15-26 interleukin 12b Mus musculus 143-151 15187114-8 2004 This appears to be a general mechanism because simvastatin also augments LPS-dependent activation of the TNF-alpha promoter, perhaps because the TNF-alpha promoter has C/EBP and AP-1 binding sites in a similar configuration to the IL-12p40 promoter. Simvastatin 47-58 interleukin 12b Mus musculus 231-239 15187114-9 2004 The fact that simvastatin potently augments LPS-induced IL-12p40 and TNF-alpha production has implications for the treatment of bacterial infections in statin-treated patients. Simvastatin 14-25 interleukin 12b Mus musculus 56-64 15528012-6 2004 Ethanol significantly affected the concentration of at least one of the cytokines evaluated in serum or peritoneal lavage fluid [interleukin (IL)-6, IL-10, and IL-12 p40 subunit] induced by all TLR ligands tested. Ethanol 0-7 interleukin 12b Mus musculus 160-177 15039220-1 2004 IL-12 consists of two disulfide-linked subunits, p40 and p35, that form functionally active heterodimers for the induction of Th1 cells. Disulfides 22-31 interleukin 12b Mus musculus 49-52 14679201-4 2004 As a consequence, the NO donor S-nitroso-N-acetylpenicillamine (SNAP) inhibits lipopolysaccharide (LPS)-induced IL-12 p40 mRNA expression, protein production, and promoter activity in murine macrophages, dendritic cells, and the murine macrophage cell line RAW 264.7. S-Nitroso-N-Acetylpenicillamine 64-68 interleukin 12b Mus musculus 112-121 14996416-3 2004 Resveratrol also significantly suppressed the ability of BM-DC to produce intracellular IL-12 p40/p70 and secretory IL-12 p70 in response to lipopolysaccharides (LPS) stimulation. Resveratrol 0-11 interleukin 12b Mus musculus 88-97 12752312-9 2003 Sirolimus treatment resulted in decreased expression of IL-12p40, IFN-gamma and IL-10 mRNA. Sirolimus 0-9 interleukin 12b Mus musculus 56-64 14573655-1 2003 Interleukin-12 (IL-12) has been inversely associated with disease severity in human and murine malaria, and a polymorphism in the IL-12 p40 subunit gene (IL12B) has been associated with susceptibility to human cerebral malaria and reduced nitric oxide (NO) production. Nitric Oxide 239-251 interleukin 12b Mus musculus 130-152 14573655-1 2003 Interleukin-12 (IL-12) has been inversely associated with disease severity in human and murine malaria, and a polymorphism in the IL-12 p40 subunit gene (IL12B) has been associated with susceptibility to human cerebral malaria and reduced nitric oxide (NO) production. Nitric Oxide 239-251 interleukin 12b Mus musculus 154-159 12871593-7 2003 Interestingly, PD98059, an inhibitor of ERK, inhibited p40-induced expression of TNF-alpha through the inhibition of C/EBPbeta, but not that of NF-kappaB, whereas SB203580, an inhibitor of p38 MAPK, inhibited p40-induced expression of TNF-alpha through the inhibition of both NF-kappaB and C/EBPbeta. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 15-22 interleukin 12b Mus musculus 55-58 12871593-7 2003 Interestingly, PD98059, an inhibitor of ERK, inhibited p40-induced expression of TNF-alpha through the inhibition of C/EBPbeta, but not that of NF-kappaB, whereas SB203580, an inhibitor of p38 MAPK, inhibited p40-induced expression of TNF-alpha through the inhibition of both NF-kappaB and C/EBPbeta. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 15-22 interleukin 12b Mus musculus 209-212 12871593-7 2003 Interestingly, PD98059, an inhibitor of ERK, inhibited p40-induced expression of TNF-alpha through the inhibition of C/EBPbeta, but not that of NF-kappaB, whereas SB203580, an inhibitor of p38 MAPK, inhibited p40-induced expression of TNF-alpha through the inhibition of both NF-kappaB and C/EBPbeta. SB 203580 163-171 interleukin 12b Mus musculus 55-58 12871593-7 2003 Interestingly, PD98059, an inhibitor of ERK, inhibited p40-induced expression of TNF-alpha through the inhibition of C/EBPbeta, but not that of NF-kappaB, whereas SB203580, an inhibitor of p38 MAPK, inhibited p40-induced expression of TNF-alpha through the inhibition of both NF-kappaB and C/EBPbeta. SB 203580 163-171 interleukin 12b Mus musculus 209-212 12688424-3 2003 It was found that the glutathione reductase inhibitor, 1,3-bis (2-chloroethyl)-1-nitrosourea, markedly augmented LPS induced IL-12p40 production particularly when it was added for 24 h before LPS stimulation, whereas the glutathione-synthesis inhibitor, L-buthionine-(S,R)-sulfoximine, suppressed IL-12p40 production. Carmustine 55-92 interleukin 12b Mus musculus 125-133 12688424-3 2003 It was found that the glutathione reductase inhibitor, 1,3-bis (2-chloroethyl)-1-nitrosourea, markedly augmented LPS induced IL-12p40 production particularly when it was added for 24 h before LPS stimulation, whereas the glutathione-synthesis inhibitor, L-buthionine-(S,R)-sulfoximine, suppressed IL-12p40 production. Carmustine 55-92 interleukin 12b Mus musculus 297-305 12688424-3 2003 It was found that the glutathione reductase inhibitor, 1,3-bis (2-chloroethyl)-1-nitrosourea, markedly augmented LPS induced IL-12p40 production particularly when it was added for 24 h before LPS stimulation, whereas the glutathione-synthesis inhibitor, L-buthionine-(S,R)-sulfoximine, suppressed IL-12p40 production. Glutathione 22-33 interleukin 12b Mus musculus 125-133 12688424-3 2003 It was found that the glutathione reductase inhibitor, 1,3-bis (2-chloroethyl)-1-nitrosourea, markedly augmented LPS induced IL-12p40 production particularly when it was added for 24 h before LPS stimulation, whereas the glutathione-synthesis inhibitor, L-buthionine-(S,R)-sulfoximine, suppressed IL-12p40 production. Glutathione 22-33 interleukin 12b Mus musculus 297-305 14971048-5 2004 CpG oligodeoxynucleotide-induced IL-12p40 and TNF-alpha production, another MyD88-dependent TLR-mediated signal, was also suppressed by C1q treatment. Oligodeoxyribonucleotides 4-24 interleukin 12b Mus musculus 33-41 14688362-9 2004 An overall reduction in gammaHV-68-induced IFN-gamma production was observed in IL-12p40(-/-) mice, suggesting that most of the viral-induced IFN-gamma in C57BL/6 mice was IL-12 dependent. gammahv 24-31 interleukin 12b Mus musculus 80-88 14611683-7 2003 Delayed addition of these ODNs for up to 2 h was still able to profoundly affect CpG-induced IL-12p40 production at 18 h. Inhibitory DNA motif consists of two nucleotide triplets, a proximal pyrimidine-rich CCT sequence and a more distal GGG triplet. pyrimidine 191-201 interleukin 12b Mus musculus 93-101 12807487-5 2003 Addition of neutralizing anti-IL-12p40 monoclonal antibody to cultures of berberine-pretreated macrophages and CD4+ T cells restored IL-4 production in antigen-primed CD4+ T cells. Berberine 74-83 interleukin 12b Mus musculus 30-38 12757742-7 2003 The results show that STE alone stimulates p40 and p35 promoter activity and enhances IFN-gamma-induced p40 and p35 promoter activity. ste 22-25 interleukin 12b Mus musculus 43-46 12757742-7 2003 The results show that STE alone stimulates p40 and p35 promoter activity and enhances IFN-gamma-induced p40 and p35 promoter activity. ste 22-25 interleukin 12b Mus musculus 104-107 12757742-11 2003 SN50, an inhibitor of NF-kappaB nuclear localization, significantly lowered STE-induced p35 and p40 promoter activity. ste 76-79 interleukin 12b Mus musculus 96-99 12688424-3 2003 It was found that the glutathione reductase inhibitor, 1,3-bis (2-chloroethyl)-1-nitrosourea, markedly augmented LPS induced IL-12p40 production particularly when it was added for 24 h before LPS stimulation, whereas the glutathione-synthesis inhibitor, L-buthionine-(S,R)-sulfoximine, suppressed IL-12p40 production. l-buthionine sulfoximine 254-284 interleukin 12b Mus musculus 125-133 12688424-4 2003 The profile of IL-12p40 augmentation correlated well with the profile of intracellular glutathione oxidation (GSSG) and the activation profile of nuclear transcription factor kappaB (NF-kappaB), suggesting that GSSG is important in NF-kappaB activation which leads to IL-12p40 production. Glutathione 87-98 interleukin 12b Mus musculus 15-23 12688424-4 2003 The profile of IL-12p40 augmentation correlated well with the profile of intracellular glutathione oxidation (GSSG) and the activation profile of nuclear transcription factor kappaB (NF-kappaB), suggesting that GSSG is important in NF-kappaB activation which leads to IL-12p40 production. Glutathione Disulfide 110-114 interleukin 12b Mus musculus 15-23 12688424-4 2003 The profile of IL-12p40 augmentation correlated well with the profile of intracellular glutathione oxidation (GSSG) and the activation profile of nuclear transcription factor kappaB (NF-kappaB), suggesting that GSSG is important in NF-kappaB activation which leads to IL-12p40 production. Glutathione Disulfide 211-215 interleukin 12b Mus musculus 15-23 12688424-4 2003 The profile of IL-12p40 augmentation correlated well with the profile of intracellular glutathione oxidation (GSSG) and the activation profile of nuclear transcription factor kappaB (NF-kappaB), suggesting that GSSG is important in NF-kappaB activation which leads to IL-12p40 production. Glutathione Disulfide 211-215 interleukin 12b Mus musculus 268-276 12688424-5 2003 Our results indicate that the glutathione-redox couple plays an important role in the augmented production of IL-12p40 and thus in influencing immune response patterns. Glutathione 30-41 interleukin 12b Mus musculus 110-118 12421981-5 2002 AM cultured with CpG but not control ODN up-regulated IL-12 p40 expression and release, and these effects were blocked by the highly specific p38 MAP kinase inhibitor SB202190. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 167-175 interleukin 12b Mus musculus 60-63 14575147-3 2003 Histamine treatment of iDC significantly increased the IL-12 p40 mRNA and protein levels compared to histamine untreated iDC. Histamine 0-9 interleukin 12b Mus musculus 61-64 14575147-5 2003 However, histamine significantly decreased IL-12 p40 production by lipopolysaccharide (LPS)-stimulated DC in a concentration dependent manner. Histamine 9-18 interleukin 12b Mus musculus 49-52 12414157-9 2002 However, reduction of p40 IL-12 in vivo through administration of indomethacin reduced the infection without a concomitant measurable increase in IFN-gamma. Indomethacin 66-78 interleukin 12b Mus musculus 22-25 12648815-9 2003 In spite of MTX treatment, the expressions of IL-1alpha and IL-12p40 mRNA sustained in spleen cells. Methotrexate 12-15 interleukin 12b Mus musculus 60-68 12528891-0 2002 cAMP elevators inhibit LPS-induced IL-12 p40 expression by interfering with phosphorylation of p38 MAPK in murine peritoneal macrophages. Cyclic AMP 0-4 interleukin 12b Mus musculus 41-44 12528891-3 2002 The present study examined a possible molecular mechanism involved in cAMP elevators-induced inhibition of IL-12 p40 expression in response to LPS. Cyclic AMP 70-74 interleukin 12b Mus musculus 113-116 12528891-4 2002 Our data demonstrated that cAMP elevators downregulated IL-12 p40 mRNA expression and IL-12 p70 production in murine peritoneal macrophages. Cyclic AMP 27-31 interleukin 12b Mus musculus 62-65 12034375-0 2002 Involvement of p38 mitogen-activated protein kinase in the induction of interleukin-12 p40 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid. Berberine 126-135 interleukin 12b Mus musculus 87-90 12193738-1 2002 The p40 subunit of IL-12 (IL-12p40), but not the heterodimeric form IL-12p70, is secreted during the development of silica-induced lung fibrosis in C57BL/6 mice. Silicon Dioxide 116-122 interleukin 12b Mus musculus 19-24 12193738-1 2002 The p40 subunit of IL-12 (IL-12p40), but not the heterodimeric form IL-12p70, is secreted during the development of silica-induced lung fibrosis in C57BL/6 mice. Silicon Dioxide 116-122 interleukin 12b Mus musculus 26-34 12193738-3 2002 IL-12p35(-/-) and IL-12p40(-/-) animals developed strikingly contrasting responses to silica in comparison with wild-type C57BL/6 mice. Silicon Dioxide 86-92 interleukin 12b Mus musculus 18-26 12193738-5 2002 Furthermore, the silica-induced increase in lung IL-12p40 content was significantly higher in IL-12p35(-/-) mice than in wild-type controls, and was associated with extensive lung fibrosis and pulmonary macrophage infiltration. Silicon Dioxide 17-23 interleukin 12b Mus musculus 49-57 12193738-8 2002 In vivo, supplementation with rIL-12p40 restored the impaired pulmonary fibrotic response and macrophage accumulation in silica-treated IL-12p40(-/-) mice, and also promoted fibrosis and macrophage influx in wild-type mice. Silicon Dioxide 121-127 interleukin 12b Mus musculus 31-39 12193738-9 2002 Together, our data suggest that IL-12p40 plays an important role in silica-induced pulmonary inflammation and fibrosis, possibly by exacerbating macrophage recruitment. Silicon Dioxide 68-74 interleukin 12b Mus musculus 32-40 12034375-0 2002 Involvement of p38 mitogen-activated protein kinase in the induction of interleukin-12 p40 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid. benzodioxoloquinolizine alkaloid 139-171 interleukin 12b Mus musculus 87-90 12034375-2 2002 In this study, we investigated the effects of berberine, a benzodioxoloquinolizine alkaloid with anti-microbial and anti-tumor activities, on the production of IL-12 p40, an inducible subunit of IL-12, in mouse macrophages. Berberine 46-55 interleukin 12b Mus musculus 160-169 12034375-3 2002 Berberine-induced IL-12 p40 production and activation of p38 mitogen-activated protein kinase (MAPK) in dose-dependent manners, which were significantly inhibited by p38 MAPK inhibitors and yohimbine, indicating that p38 MAPK and alpha(2)-adrenergic receptor were involved in the induction of IL-12 p40 production in mouse macrophages by berberine. Berberine 0-9 interleukin 12b Mus musculus 24-27 12034375-3 2002 Berberine-induced IL-12 p40 production and activation of p38 mitogen-activated protein kinase (MAPK) in dose-dependent manners, which were significantly inhibited by p38 MAPK inhibitors and yohimbine, indicating that p38 MAPK and alpha(2)-adrenergic receptor were involved in the induction of IL-12 p40 production in mouse macrophages by berberine. Berberine 0-9 interleukin 12b Mus musculus 299-302 12034375-3 2002 Berberine-induced IL-12 p40 production and activation of p38 mitogen-activated protein kinase (MAPK) in dose-dependent manners, which were significantly inhibited by p38 MAPK inhibitors and yohimbine, indicating that p38 MAPK and alpha(2)-adrenergic receptor were involved in the induction of IL-12 p40 production in mouse macrophages by berberine. Yohimbine 190-199 interleukin 12b Mus musculus 24-27 12034375-3 2002 Berberine-induced IL-12 p40 production and activation of p38 mitogen-activated protein kinase (MAPK) in dose-dependent manners, which were significantly inhibited by p38 MAPK inhibitors and yohimbine, indicating that p38 MAPK and alpha(2)-adrenergic receptor were involved in the induction of IL-12 p40 production in mouse macrophages by berberine. Yohimbine 190-199 interleukin 12b Mus musculus 299-302 12034375-4 2002 Furthermore, berberine significantly enhanced IL-12 p40 production in mouse macrophages when combined with lipopolysaccharide, a well-known inducer of IL-12 production. Berberine 13-22 interleukin 12b Mus musculus 52-55 11927655-3 2002 Thiazolidinediones and 15d-PGJ2 suppressed lipopolysaccharide (LPS)-induced PEM production of NO and IL-12(p40) to a greater extent than IL-6 and TNF-alpha production. Thiazolidinediones 0-18 interleukin 12b Mus musculus 107-110 12021842-4 2002 Quantitative RT-PCR analysis of pancreatic mRNA showed that cyclophosphamide induced the expression of Th1 cytokines (IFN-gamma and IL-12p40) in vehicle- or control plasmid-treated mice. Cyclophosphamide 60-76 interleukin 12b Mus musculus 132-140 11927655-3 2002 Thiazolidinediones and 15d-PGJ2 suppressed lipopolysaccharide (LPS)-induced PEM production of NO and IL-12(p40) to a greater extent than IL-6 and TNF-alpha production. 15-deoxy-delta(12,14)-prostaglandin J2 23-31 interleukin 12b Mus musculus 107-110 11884420-3 2002 In this study, we demonstrate that c-Rel is also required for IL-12p40 production by macrophages in response to Corynebacterium parvum, CpG oligodeoxynucleotides, anti-CD40 and low molecular weight hyaluronic acid. CPG-oligonucleotide 136-161 interleukin 12b Mus musculus 62-70 12061835-7 2002 IL-12 dimer formation appears to be reduced by NAC also in vivo, because pretreatment with NAC (1 g/kg, orally), before LPS injection in mice, inhibited peak IL-12 p75 serum levels without affecting those of p40. Acetylcysteine 91-94 interleukin 12b Mus musculus 208-211 11884420-3 2002 In this study, we demonstrate that c-Rel is also required for IL-12p40 production by macrophages in response to Corynebacterium parvum, CpG oligodeoxynucleotides, anti-CD40 and low molecular weight hyaluronic acid. Hyaluronic Acid 198-213 interleukin 12b Mus musculus 62-70 11823513-7 2002 Infected IL-12p40(-/-) and IFN-gamma(-/-) mice also mounted anti-Citrobacter serum and gut-associated IgA responses and strongly expressed inducible NO synthase (iNOS) in mucosal tissue, despite diminished serum nitrite/nitrate levels. Nitrites 212-219 interleukin 12b Mus musculus 9-17 11823513-7 2002 Infected IL-12p40(-/-) and IFN-gamma(-/-) mice also mounted anti-Citrobacter serum and gut-associated IgA responses and strongly expressed inducible NO synthase (iNOS) in mucosal tissue, despite diminished serum nitrite/nitrate levels. Nitrates 220-227 interleukin 12b Mus musculus 9-17 11784117-0 2002 IL-12p40(-/-) mice treated with intratracheal bleomycin exhibit decreased pulmonary inflammation and increased fibrosis. Bleomycin 46-55 interleukin 12b Mus musculus 0-8 11784117-5 2002 IL-12p40(-/-) mice treated with BLM intratracheally showed less pulmonary mononuclear cell inflammation at Day 7 than wild-type controls, whereas pulmonary fibrosis and hydroxyproline content were increased in IL-12p40(-/-) mice at Day 14. Hydroxyproline 169-183 interleukin 12b Mus musculus 210-218 11777541-0 2002 Dopamine suppresses IL-12 p40 production by lipopolysaccharide-stimulated macrophages via a beta-adrenoceptor-mediated mechanism. Dopamine 0-8 interleukin 12b Mus musculus 20-29 11782017-7 2002 These results demonstrate that IL-12p40, in contrast to IL-12p70, inhibits TNBS-induced colitis and IL-18 expression independent of IFN-gamma. Trinitrobenzenesulfonic Acid 75-79 interleukin 12b Mus musculus 31-39 11818448-2 2002 We have shown that peritoneal macrophages from IL-12p40 gene knockout mice have a bias toward the M2 profile, spontaneously secreting large amounts of TGF-beta 1 and responding to rIFN-gamma with weak NO production. rifn-gamma 180-190 interleukin 12b Mus musculus 47-55 11777541-1 2002 In this study, we examined the effect of dopamine on the production of IL-12 p40 by lipopolysaccharide (LPS)-stimulated J774.1 macrophages and mouse peritoneal macrophages. Dopamine 41-49 interleukin 12b Mus musculus 77-80 11777541-2 2002 Treatment of J774.1 cells with dopamine (0.01-100 microM) decreased the release of IL-12 p40, in a concentration-dependent manner. Dopamine 31-39 interleukin 12b Mus musculus 83-92 11777541-3 2002 The attenuating effect of dopamine on IL-12 p40 production appeared to be pretranslational, because dopamine decreased mRNA accumulation of IL-12 p40. Dopamine 26-34 interleukin 12b Mus musculus 38-47 11777541-3 2002 The attenuating effect of dopamine on IL-12 p40 production appeared to be pretranslational, because dopamine decreased mRNA accumulation of IL-12 p40. Dopamine 26-34 interleukin 12b Mus musculus 140-149 11777541-3 2002 The attenuating effect of dopamine on IL-12 p40 production appeared to be pretranslational, because dopamine decreased mRNA accumulation of IL-12 p40. Dopamine 100-108 interleukin 12b Mus musculus 38-47 11777541-3 2002 The attenuating effect of dopamine on IL-12 p40 production appeared to be pretranslational, because dopamine decreased mRNA accumulation of IL-12 p40. Dopamine 100-108 interleukin 12b Mus musculus 140-149 11777541-4 2002 The inhibitory effect of dopamine on IL-12 p40 production by J774.1 macrophages was not mediated by dopamine receptors, because dopamine receptor antagonists were unable to reverse the dopamine-induced suppression of IL-12 p40 production. Dopamine 25-33 interleukin 12b Mus musculus 37-46 11777541-5 2002 Since the beta-adrenoceptor antagonist propranolol completely prevented the inhibitory effect of dopamine on IL-12 p40 production, the suppressive effect of dopamine on IL-12 p40 production by J774.1 cells is mediated by beta-adrenoceptors. Propranolol 39-50 interleukin 12b Mus musculus 109-118 11777541-5 2002 Since the beta-adrenoceptor antagonist propranolol completely prevented the inhibitory effect of dopamine on IL-12 p40 production, the suppressive effect of dopamine on IL-12 p40 production by J774.1 cells is mediated by beta-adrenoceptors. Dopamine 97-105 interleukin 12b Mus musculus 109-118 11777541-5 2002 Since the beta-adrenoceptor antagonist propranolol completely prevented the inhibitory effect of dopamine on IL-12 p40 production, the suppressive effect of dopamine on IL-12 p40 production by J774.1 cells is mediated by beta-adrenoceptors. Dopamine 157-165 interleukin 12b Mus musculus 169-178 11724637-11 2001 LPS-induced IL-12 p40 mRNA expression was increased in the spleens of glucan-treated mice compared with controls. Glucans 70-76 interleukin 12b Mus musculus 12-21 11739531-3 2001 The addition of DHEA to cultures of myelin basic protein-primed splenocytes resulted in a significant decrease in T cell proliferation and secretion of (pro)inflammatory cytokines (IFN-gamma, IL-12 p40, and TNF-alpha) and NO in response to myelin basic protein. Dehydroepiandrosterone 16-20 interleukin 12b Mus musculus 192-201 11350791-5 2001 The results of RT-PCR showed that IL-12p40, IL-12 receptor (R) beta2, interferon-gamma, tumor necrosis factor-alpha and FasL mRNAs were upregulated after bleomycin instillation. Bleomycin 154-163 interleukin 12b Mus musculus 34-42 11592087-6 2001 Furthermore, in IFN-gamma and IL-12p40 double KO mice, exogenous rIL-12 completely loses antitumor efficacy, suggesting the existence of an IFN-gamma-independent IL-12 effect that does require the presence of endogenous IL-12p40 chain. ril-12 65-71 interleukin 12b Mus musculus 30-38 11592087-6 2001 Furthermore, in IFN-gamma and IL-12p40 double KO mice, exogenous rIL-12 completely loses antitumor efficacy, suggesting the existence of an IFN-gamma-independent IL-12 effect that does require the presence of endogenous IL-12p40 chain. ril-12 65-71 interleukin 12b Mus musculus 220-228 11410248-4 2001 The effect of parthenolide on IL-12 p40 promoter activation was analyzed by transfecting RAW264.7 monocytic cells with p40 promoter/luciferase constructs. parthenolide 14-26 interleukin 12b Mus musculus 30-39 11410248-4 2001 The effect of parthenolide on IL-12 p40 promoter activation was analyzed by transfecting RAW264.7 monocytic cells with p40 promoter/luciferase constructs. parthenolide 14-26 interleukin 12b Mus musculus 36-39 11708898-5 2001 The results suggest that differential expression of IL-12p40 and IL-4 mRNA after 24 h allows clear discrimination between DNCB and TMA in C57BL/6 mice, more obviously than in Balb/c mice. Dinitrochlorobenzene 122-126 interleukin 12b Mus musculus 52-60 11350791-7 2001 The results of enzyme-linked immunosorbent assay showed that the levels of IL-12p40, but not of IL-12p70, were increased in lung tissue after bleomycin instillation. Bleomycin 142-151 interleukin 12b Mus musculus 75-83 11412311-3 2001 In this study, GL showed a dose-dependent priming effect on lipopolysaccharide (LPS)-induced IL-12 p40 and IL-12 p70 (heterodimer of p40 and p35) protein production by peritoneal macrophages (PM). Glycyrrhizic Acid 15-17 interleukin 12b Mus musculus 93-102 11412311-3 2001 In this study, GL showed a dose-dependent priming effect on lipopolysaccharide (LPS)-induced IL-12 p40 and IL-12 p70 (heterodimer of p40 and p35) protein production by peritoneal macrophages (PM). Glycyrrhizic Acid 15-17 interleukin 12b Mus musculus 99-102 11412311-6 2001 The augmentation of IL-12 p40 mRNA expression induced by GL pretreatment was associated with increased NF-kappaB activation. Glycyrrhizic Acid 57-59 interleukin 12b Mus musculus 20-29 11367535-7 2001 In addition, the administration of RJ to DNP-KLH mice increased IL-12 p40 mRNA expression and NO production, and decreased PG E2 production from macrophages as compared to untreated DNP-KLH mice. dnp-klh 41-48 interleukin 12b Mus musculus 64-73 11409710-7 2001 NOD/LtJ and NOD/Bom mice were found significantly to upregulate pancreatic IL-12p40 and IL-18 expression after cyclophosphamide treatment, followed by an increase in IFN-gamma mRNA levels. Cyclophosphamide 111-127 interleukin 12b Mus musculus 75-83 11409710-9 2001 The two strains sharing MHC haplotype H-2g7 expression with NOD did respond to cyclophosphamide with IL-12p40/IL-18 gene expression. Cyclophosphamide 79-95 interleukin 12b Mus musculus 101-109 11422205-4 2001 The inhibitory effect of PTX was specific for IL-18, since LPS-induced IL-12 p40 release was not suppressed either in splenocyte cultures or blood of LPS-injected animals. Pentoxifylline 25-28 interleukin 12b Mus musculus 71-80 11311890-4 2001 Sympathomimetics such as salbutamol dose-dependently inhibited IL-12p40 release, whereas the production of IL-6, TNFalpha and MIP-1alpha was only marginally influenced. Albuterol 25-35 interleukin 12b Mus musculus 63-71 11311890-6 2001 The cAMP-elevating agent forskolin could mimic the effects of beta-agonists, indicating that IL-12p40 release inhibition involves intracellular cAMP accumulation. Cyclic AMP 4-8 interleukin 12b Mus musculus 93-101 11311890-6 2001 The cAMP-elevating agent forskolin could mimic the effects of beta-agonists, indicating that IL-12p40 release inhibition involves intracellular cAMP accumulation. Colforsin 25-34 interleukin 12b Mus musculus 93-101 11311890-6 2001 The cAMP-elevating agent forskolin could mimic the effects of beta-agonists, indicating that IL-12p40 release inhibition involves intracellular cAMP accumulation. Cyclic AMP 144-148 interleukin 12b Mus musculus 93-101 10934192-6 2000 9-Hydroxyoctadecadienoic acid, a major oxidized lipid component of oxLDL, significantly inhibited IL-12 production in LPS-stimulated mouse macrophages and also suppressed NF-kappaB-mediated activation in IL-12 p40 promoter. 9-hydroxyoctadecadienoic acid 0-29 interleukin 12b Mus musculus 204-213 11162546-9 2001 Moreover, nuclear localization of NF-kappaB was observed after stimulation of IL-12 or IL-12 p40 in MC-38 and Colon-26-NL-17 cells, but not in Panc-02 cells. mc-38 100-105 interleukin 12b Mus musculus 93-96 11123339-6 2001 In contrast, for optimal induction of COX-2, IL-12 p35, and IL-12 p40 genes by low concentrations of LPS or by all concentrations of Taxol, CD11b/CD18 was also required. Paclitaxel 133-138 interleukin 12b Mus musculus 66-69 11123339-7 2001 Mitigated induction of COX-2, IL-12 p35, and IL-12 p40 gene expression by CD11b/CD18-deficient macrophages correlated with a marked inhibition of NF-kappa B nuclear translocation and mitogen-activated protein kinase (MAPK) activation in response to Taxol and of NF-kappa B nuclear translocation in response to LPS. Paclitaxel 249-254 interleukin 12b Mus musculus 45-54 11073113-6 2000 Morphine enhanced mRNA expression of interleukin (IL)-12 p40 and tumor necrosis factor alpha (TNF-alpha) compared with controls, whereas IL-10 levels were unchanged by drug treatment. Morphine 0-8 interleukin 12b Mus musculus 57-60 11073113-7 2000 ELISA data showed that both IL-12 p40 and p70 were increased by morphine. Morphine 64-72 interleukin 12b Mus musculus 34-37 10944484-6 2000 In addition, splenic cytokine mRNA for IL-12 p40, tumor necrosis factor-alpha, and IL-1beta were lower in infected mice fed n-3 PUFA-containing diets than in mice fed the olive oil ethyl esters control diet. pufa 128-132 interleukin 12b Mus musculus 39-48 10996031-0 2000 Differential effects of pentoxifylline, a non-specific phosphodiesterase inhibitor, on the production of IL-10, IL-12 p40 and p35 subunits by murine peritoneal macrophages. Pentoxifylline 24-38 interleukin 12b Mus musculus 112-121 10996031-11 2000 However, at higher concentrations, PTX inhibited the production of TNF-alpha, IL-10, and IL-12 p35, but surprisingly, PTX enhanced the production of IL-12 p40. Pentoxifylline 118-121 interleukin 12b Mus musculus 149-158 10946255-3 2000 We report that Alexa488-labeled P40 binds (at 4 degrees C) to murine and human macrophages in a dose-dependent manner and is rapidly internalized (at 37 degrees C). alexa488 15-23 interleukin 12b Mus musculus 32-35 10696089-8 2000 The effect of ATP was pretranslational, as it suppressed steady state levels of mRNAs for IL-12 (both p35 and p40). Adenosine Triphosphate 14-17 interleukin 12b Mus musculus 110-113 10947939-11 2000 The levels of mIL-12 p40, mIL-12 p70, and mIFN-gamma were significantly higher for PAGA/pmIL-12 complexes compared to that of naked pmIL-12. mil-12 14-20 interleukin 12b Mus musculus 21-24 10947939-11 2000 The levels of mIL-12 p40, mIL-12 p70, and mIFN-gamma were significantly higher for PAGA/pmIL-12 complexes compared to that of naked pmIL-12. poly((4-aminobutyl)glycolic acid) 83-87 interleukin 12b Mus musculus 21-24 10947939-11 2000 The levels of mIL-12 p40, mIL-12 p70, and mIFN-gamma were significantly higher for PAGA/pmIL-12 complexes compared to that of naked pmIL-12. pmil-12 88-95 interleukin 12b Mus musculus 21-24 10947158-0 2000 Spermine differentially regulates the production of interleukin-12 p40 and interleukin-10 and suppresses the release of the T helper 1 cytokine interferon-gamma. Spermine 0-8 interleukin 12b Mus musculus 67-70 10947158-3 2000 In the present study, we investigated the effect of the polyamines spermine, spermidine, and putrescine on the production of interleukin (IL)-12 p40, IL-10, and interferon (IFN-gamma) in mouse peritoneal macrophages and spleen cell suspensions. Polyamines 56-66 interleukin 12b Mus musculus 145-148 10947158-3 2000 In the present study, we investigated the effect of the polyamines spermine, spermidine, and putrescine on the production of interleukin (IL)-12 p40, IL-10, and interferon (IFN-gamma) in mouse peritoneal macrophages and spleen cell suspensions. Spermine 67-75 interleukin 12b Mus musculus 145-148 10947158-3 2000 In the present study, we investigated the effect of the polyamines spermine, spermidine, and putrescine on the production of interleukin (IL)-12 p40, IL-10, and interferon (IFN-gamma) in mouse peritoneal macrophages and spleen cell suspensions. Spermidine 77-87 interleukin 12b Mus musculus 145-148 10947158-3 2000 In the present study, we investigated the effect of the polyamines spermine, spermidine, and putrescine on the production of interleukin (IL)-12 p40, IL-10, and interferon (IFN-gamma) in mouse peritoneal macrophages and spleen cell suspensions. Putrescine 93-103 interleukin 12b Mus musculus 145-148 10947158-4 2000 Spermine, but not spermidine or putrescine, suppressed, in a concentration-dependent manner, the production of IL-12 p40 by lipopolysaccharide (LPS)-stimulated macrophages. Spermine 0-8 interleukin 12b Mus musculus 111-120 10947158-7 2000 The down-regulation of IL-12 p40 by spermine was independent of enhancement of IL-10 by this agent, for spermine retained its ability to suppress IL-12 production in peritoneal macrophages obtained from IL-10-deficient mice. Spermine 36-44 interleukin 12b Mus musculus 29-32 10878369-12 2000 Finally, depletion of NK cells by anti-asialo GM1 Ab mostly abrogated the residual production of IFN-gamma in IL-12p40-/- mice. G(M1) Ganglioside 46-49 interleukin 12b Mus musculus 110-118 10820397-5 2000 Moreover, IL-18 and IL-12 p40 RNA levels were comparably up-regulated after TNBS treatment in IFN-gammaR1(- / -) wild-type mice. Trinitrobenzenesulfonic Acid 76-80 interleukin 12b Mus musculus 26-29 10798593-6 2000 RESULTS: Ethanol pretreatment suppressed LPS-induced IL-12 p70 and p40 protein production in blood and lung. Ethanol 9-16 interleukin 12b Mus musculus 67-70 10798593-7 2000 In spleen and lung, p40 mRNA was induced to a greater extent than p35 mRNA, and there was greater suppression of p40 mRNA compared with p35 mRNA in ethanol-treated animals. Ethanol 148-155 interleukin 12b Mus musculus 113-116 10798593-8 2000 Ethanol up-regulated the production of IL-10, and pretreatment of these animals with a polyclonal anti-IL-10 antibody resulted in significant increases in IL-12 p70 and p40 levels, but not completely to those of control animals. Ethanol 0-7 interleukin 12b Mus musculus 169-172 10569700-6 1999 In addition, the IL-12 p40 mRNA expression in splenic adherent cells and IFN-gamma mRNA expression in CD4+ T cells were increased by the administration of Z-100 to tumor bearing mice. specific substance maruyama 155-160 interleukin 12b Mus musculus 17-26 10611441-4 1999 The effect of curcumin on interleukin-12 p40 promoter activation was analyzed by transfecting RAW264.7 monocytic cells with p40 promoter/reporter constructs. Curcumin 14-22 interleukin 12b Mus musculus 41-44 10611441-4 1999 The effect of curcumin on interleukin-12 p40 promoter activation was analyzed by transfecting RAW264.7 monocytic cells with p40 promoter/reporter constructs. Curcumin 14-22 interleukin 12b Mus musculus 124-127 10469239-3 1999 Sulfasalazine potently inhibited the production of IL-12 in a dose-dependent manner, in part through the down-regulation of nuclear factor kappaB (NFkappaB) activation in IL-12 p40 gene. Sulfasalazine 0-13 interleukin 12b Mus musculus 171-180 10455266-5 1999 The protein kinase A inhibitor H-89 partially reversed the inhibitory effects of dibutyryl cyclic AMP and PGE2 on both IL-12(p40) and TNF-alpha synthesis. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 31-35 interleukin 12b Mus musculus 125-128 10453037-5 1999 However, the induction of IL-12p40 by dox was sufficient for inhibiting tumor formation, as well as for tumor regression. Doxycycline 38-41 interleukin 12b Mus musculus 26-34 10455266-5 1999 The protein kinase A inhibitor H-89 partially reversed the inhibitory effects of dibutyryl cyclic AMP and PGE2 on both IL-12(p40) and TNF-alpha synthesis. Bucladesine 81-101 interleukin 12b Mus musculus 125-128 10455266-5 1999 The protein kinase A inhibitor H-89 partially reversed the inhibitory effects of dibutyryl cyclic AMP and PGE2 on both IL-12(p40) and TNF-alpha synthesis. Dinoprostone 106-110 interleukin 12b Mus musculus 125-128 10455266-9 1999 Together, our findings favour the hypothesis that the cyclic AMP inhibitory activity on IL-12(p40) but not on TNF-alpha synthesis is dependent on de novo protein synthesis, most likely involving IL-10, by macrophages stimulated with microbial products. Cyclic AMP 54-64 interleukin 12b Mus musculus 94-97 10455266-10 1999 Accordingly, dibutyryl cyclic AMP inhibited IL-12(p40) synthesis only when added before or at the same time of the stimuli. Bucladesine 13-33 interleukin 12b Mus musculus 50-53 10100987-0 1999 Lung fibrosis induced by silica particles in NMRI mice is associated with an upregulation of the p40 subunit of interleukin-12 and Th-2 manifestations. Silicon Dioxide 25-31 interleukin 12b Mus musculus 97-100 10358184-8 1999 In addition, Taxol-induced IL-12 p40 mRNA was markedly reduced in Mac-1 knockout macrophages and anti-Mac-1 Ab blocked secretion of IL-12 p70 in Taxol- and LPS-stimulated macrophages. Paclitaxel 13-18 interleukin 12b Mus musculus 27-36 9550379-9 1997 Consistent with this idea, fewer IL-12 p40-secreting Mac-3+ cells were found in male mice compared with female mice, and treatment with rIL-12 resulted in the priming of Th1 cells in male mice. ril-12 136-142 interleukin 12b Mus musculus 33-42 9949322-8 1999 By using an in vivo approach, sensitization of the skin with trinitrochlorbenzene, but not with ovalbumin, resulted in an early induction of IL-1beta, IL-12p40, and IFN-gamma mRNA in LNCs, whereas IL-18 was induced by both. trinitrochlorbenzene 61-81 interleukin 12b Mus musculus 151-159 10199581-4 1999 Cultured LNC prepared from mice treated with DNCB secreted significantly more IL-12 p40 protein than did TMA- or vehicle-activated LNC, such differences becoming more pronounced as the duration of culture increased. Dinitrochlorobenzene 45-49 interleukin 12b Mus musculus 78-87 9707511-10 1998 However, when VT-fed mice were also challenged with an oral dose of VT equivalent to daily intake at 2 h prior to RNA isolation, vigorous mRNA responses were observed for IL-1beta, IL-6, TNF-alpha, IL-12p40, IL-12p35, IL-2, IFN-gamma, IL-4, and IL-10. deoxynivalenol 14-16 interleukin 12b Mus musculus 198-206 9421488-4 1998 1,25(OH)2D3 significantly inhibits mRNA expression for both IL-12 p35 and p40 subunits acting at the transcriptional level. Calcitriol 0-11 interleukin 12b Mus musculus 74-77 9421488-5 1998 The effect of 1,25(OH)2D3 on p40 promoter activation was analyzed by cotransfecting monocytic RAW264.7 cells with p40 promoter/reporter constructs and expression vectors for vitamin D3 receptor (VDR) and/or retinoid X receptor (RXRalpha). Calcitriol 14-25 interleukin 12b Mus musculus 29-32 9421488-10 1998 Thus, 1,25(OH)2D3 may negatively regulate IL-12 production by downregulation of NF-kappaB activation and binding to the p40-kappaB sequence. Calcitriol 6-17 interleukin 12b Mus musculus 120-123 9693281-6 1998 RESULTS: We observed concurrent upregulation of B7-1, B7-2, and IL-12p40 mRNA in the lung tissues at 1 h to 7 days after bleomycin instillation into the trachea. Bleomycin 121-130 interleukin 12b Mus musculus 64-72 9647215-4 1998 IL-12 p40-deficient mice (12KO) were resistant to EAU induced with the uveitogenic retinal Ag interphotoreceptor retinoid binding protein (IRBP). Water 50-53 interleukin 12b Mus musculus 0-9 9439714-10 1997 Support for the former hypothesis is based on the observation that Pb induced elevated levels of p40 splenic messenger RNA since increased p40 expression would result from lack of IL-12 formation. Lead 67-69 interleukin 12b Mus musculus 97-100 9439714-10 1997 Support for the former hypothesis is based on the observation that Pb induced elevated levels of p40 splenic messenger RNA since increased p40 expression would result from lack of IL-12 formation. Lead 67-69 interleukin 12b Mus musculus 139-142 9361908-4 1997 administration of 50 mg/kg of oligonucleotide, significant increases in the splenic mRNA levels of IL-6, IL-12p40, IL-1 beta, and IL-1Ra and serum levels of IL-6, IL-12, MIP-1 beta, and MCP-1 were observed. Oligonucleotides 30-45 interleukin 12b Mus musculus 105-113 9166427-7 1997 First, preventing extracellular calcium influxes, by performing the assays in EGTA, abrogated FcgammaR-mediated IL-12(p40) mRNA suppression. Calcium 32-39 interleukin 12b Mus musculus 118-121 9310830-7 1997 Free intracellular calcium ([Ca2+]i) increase induced by mAb cross-linking of activating CD94 or p50 was inhibited by simultaneous engagement of p40 molecules, but not of other NK surface molecules including CD44 and CD56. Calcium 19-26 interleukin 12b Mus musculus 145-148 9247296-1 1997 A 3-methylcholanthrene-induced fibrosarcoma cell line of BALB/c origin, CMS5j, was co-transfected with cDNA for the p40 and p35 subunits of interleukin-12 (IL-12). Methylcholanthrene 2-22 interleukin 12b Mus musculus 116-119 9166427-7 1997 First, preventing extracellular calcium influxes, by performing the assays in EGTA, abrogated FcgammaR-mediated IL-12(p40) mRNA suppression. Egtazic Acid 78-82 interleukin 12b Mus musculus 118-121 9166427-8 1997 Second, exposure of macrophages to the calcium ionophores, ionomycin or A23187, mimicked receptor ligation and inhibited IL-12(p40) mRNA induction by LPS. Calcium 39-46 interleukin 12b Mus musculus 127-130 9166427-8 1997 Second, exposure of macrophages to the calcium ionophores, ionomycin or A23187, mimicked receptor ligation and inhibited IL-12(p40) mRNA induction by LPS. Ionomycin 59-68 interleukin 12b Mus musculus 127-130 9166427-8 1997 Second, exposure of macrophages to the calcium ionophores, ionomycin or A23187, mimicked receptor ligation and inhibited IL-12(p40) mRNA induction by LPS. Calcimycin 72-78 interleukin 12b Mus musculus 127-130 9171935-6 1997 We found that the MSCVpac-mIL-12 vector directed robust expression of both p40 and p35 genes in several murine tumor cell lines of hematopoietic origin, including a T-cell lymphoma, a B-cell lymphoma, and a plasmacytoma/myeloma. mil-12 26-32 interleukin 12b Mus musculus 75-78 9222642-0 1997 Suppression of cyclophosphamide induced diabetes development and pancreatic Th1 reactivity in NOD mice treated with the interleukin (IL)-12 antagonist IL-12(p40)2. Cyclophosphamide 15-31 interleukin 12b Mus musculus 157-160 9222642-2 1997 Here we report that treatment with the homodimeric IL-12p40 subunit, an antagonist of the bioactive IL-12p35/p40 heterodimer, suppresses diabetes development in cyclophosphamide-injected NOD mice. Cyclophosphamide 161-177 interleukin 12b Mus musculus 51-67 9222642-2 1997 Here we report that treatment with the homodimeric IL-12p40 subunit, an antagonist of the bioactive IL-12p35/p40 heterodimer, suppresses diabetes development in cyclophosphamide-injected NOD mice. Cyclophosphamide 161-177 interleukin 12b Mus musculus 56-59 7673730-9 1995 The results from Cl2MBP-liposome-treated mice also suggested that splenic macrophages were the primary producers of LPS-induced IL-1 beta, IL-6, IL-12 (p40), and IL-1 receptor antagonist (IL-1ra) mRNA, but not IL-10 and TNF-alpha mRNA. cl2mbp 17-23 interleukin 12b Mus musculus 152-155 9127002-5 1997 Homodimer constituted between 20 and 40% of the total circulating p40 in endotoxemic sera, as confirmed by both Sephacryl S-100 gel filtration and p40-specific immunoprecipitation analyses. sephacryl s-100 112-127 interleukin 12b Mus musculus 66-69 9127002-9 1997 Mice treated with 40 to 80 microg of p40 homodimer generated 80 to 82% less circulating IFN-gamma during acute endotoxemia than saline controls (p < 0.01). Sodium Chloride 128-134 interleukin 12b Mus musculus 37-40 8576576-3 1996 Two of the MAbs, 2B5 and 9A5, were able to capture 125I-moIL-12 in the presence of unlabelled moIL-12 p35 and moIL-12 p40, suggesting specificity for the moIL-12 p75 heterodimer. 125i-moil-12 51-63 interleukin 12b Mus musculus 118-121 9035103-1 1997 Interleukin-12 (IL-12) is unique amongst cytokines in being a disulfide-linked heterodimer of two separately encoded subunits (p35 and p40). Disulfides 62-71 interleukin 12b Mus musculus 135-138 8977282-13 1996 Administration of IL-10 or IL-4 in BALB/c inhibited BPO-TT-induced expression of IL-12 p40 mRNA without modulating IFN-gamma mRNA. bpo-tt 52-58 interleukin 12b Mus musculus 81-90 8871663-4 1996 rhIL-11 pretreatment of thioglycollate-elicited peritoneal macrophages resulted in greater than 60% inhibition of LPS-induced production of TNF-alpha, IL-1beta, IL-12 p40, and nitric oxide. Thioglycolates 24-38 interleukin 12b Mus musculus 161-170 8720612-7 1996 mRNA expression of the p40 chain of interleukin-12 in response to cyclophosphamide was not seen in macrophages of Balb/c mice and thus represents an immune abnormality of non-obese diabetic mice favouring T-helper type 1 reactions. Cyclophosphamide 66-82 interleukin 12b Mus musculus 23-26 7868230-6 1995 Six hours after oral immunization with the Salmonella construct, mice had 12.1- and 8.4-fold increases in expression of IL-12 p40 mRNA in the Peyer"s patches and mesenteric lymph nodes, respectively, compared with control mice receiving only saline. Sodium Chloride 242-248 interleukin 12b Mus musculus 120-129 7704916-5 1995 In parallel to these dissociated actions, GL promoted the tyrosine phosphorylation of p56 but suppressed the phosphorylation of p40 induced by anti-CD3. Glycyrrhizic Acid 42-44 interleukin 12b Mus musculus 128-131 7606797-3 1995 IL-12 is a disulfide-linked heterodimer containing two chains (designated P35 and P40); however, bioactive cytokine production has been more closely linked with P40 expression. Disulfides 11-20 interleukin 12b Mus musculus 82-85 7843232-1 1995 Interleukin-12 (IL-12) is a cytokine that has regulatory effects on T and natural killer (NK) cells and is composed of two disulfide-bonded subunits, p40 and p35. Disulfides 123-132 interleukin 12b Mus musculus 150-153 7843232-7 1995 Purified mouse p40 produced in a baculovirus expression system was found to consist of two species: the p40 monomer and a disulfide-linked p40 dimer [(p40)2]. Disulfides 122-131 interleukin 12b Mus musculus 15-18 7843232-11 1995 Nonetheless, mouse (p40)2 was equally effective as moIL-12 in competing with [125I] huIL-12 for binding to COS cells transfected with the human IL-12R beta subunit and expressing low-affinity IL-12 binding sites. huil-12 84-91 interleukin 12b Mus musculus 20-23 8504805-2 1993 Treatment with okadaic acid caused rapid phosphorylation of five proteins with molecular masses of 65, 55, 50, 28 and 15 kDa (p65, p55, p50, p28, p15, respectively) while TPA caused rapid phosphorylation of five proteins with molecular masses of 80, 70, 40, 34 and 28 kDa (p80, p70, p40, p34, p28, respectively). Okadaic Acid 15-27 interleukin 12b Mus musculus 283-286 8103745-6 1993 The proliferation of mouse splenocytes activated by phorbol ester and IL-12 was inhibited by IL-12p40, whereas the proliferation induced by phorbol ester and IL-2 was not affected. Phorbol Esters 52-65 interleukin 12b Mus musculus 93-101 8504805-2 1993 Treatment with okadaic acid caused rapid phosphorylation of five proteins with molecular masses of 65, 55, 50, 28 and 15 kDa (p65, p55, p50, p28, p15, respectively) while TPA caused rapid phosphorylation of five proteins with molecular masses of 80, 70, 40, 34 and 28 kDa (p80, p70, p40, p34, p28, respectively). Tetradecanoylphorbol Acetate 171-174 interleukin 12b Mus musculus 283-286 7912536-5 1993 We found that Taxol, like lipopolysaccharides (LPS), caused a marked increase in tyrosine phosphorylation of three proteins having M(r) of 40 (p40), 41 (p41), and 43 (p43) kd in RAW cells. Paclitaxel 14-19 interleukin 12b Mus musculus 143-146 7912536-5 1993 We found that Taxol, like lipopolysaccharides (LPS), caused a marked increase in tyrosine phosphorylation of three proteins having M(r) of 40 (p40), 41 (p41), and 43 (p43) kd in RAW cells. Tyrosine 81-89 interleukin 12b Mus musculus 143-146 34937175-8 2021 Both IL-1alpha and IL-12 p40 were released from the alveolar macrophages depending on the TLR2 and reactive oxygen species. Reactive Oxygen Species 99-122 interleukin 12b Mus musculus 19-28 2005396-12 1991 Pulse-chase studies of IL-4R in [35S] methionine-labeled cells indicates that p40 is derived from a 42,000-Da precursor that is detectable at the end of the pulse period, and thus, further argue that p40 is an independently translated molecule and not a degradation product of p120. Sulfur-35 33-36 interleukin 12b Mus musculus 78-81 2005396-12 1991 Pulse-chase studies of IL-4R in [35S] methionine-labeled cells indicates that p40 is derived from a 42,000-Da precursor that is detectable at the end of the pulse period, and thus, further argue that p40 is an independently translated molecule and not a degradation product of p120. Methionine 38-48 interleukin 12b Mus musculus 78-81 2005396-12 1991 Pulse-chase studies of IL-4R in [35S] methionine-labeled cells indicates that p40 is derived from a 42,000-Da precursor that is detectable at the end of the pulse period, and thus, further argue that p40 is an independently translated molecule and not a degradation product of p120. Methionine 38-48 interleukin 12b Mus musculus 200-203 34339693-7 2022 Additionally, DEP-exposed animals showed increased expression of IL-23 and IL-12p40 (proinflammatory cytokines) and inducible nitric oxide synthase. dep 14-17 interleukin 12b Mus musculus 75-83 2256925-0 1990 Regulation of creatine phosphokinase B activity by protein kinase C. We previously reported that topical application of 12-o-tetradecanoylphorbol-13-acetate to mouse skin causes phosphorylation of epidermal proteins with molecular weights of 40,000 (p40) and 34,000 (p34). Tetradecanoylphorbol Acetate 120-156 interleukin 12b Mus musculus 250-253 2256926-2 1990 In the present work, p40 was purified from mouse brain by the use of 32P-labeled p40 of BALB/MK-2 cells as a tracer. Phosphorus-32 69-72 interleukin 12b Mus musculus 21-24 2256926-2 1990 In the present work, p40 was purified from mouse brain by the use of 32P-labeled p40 of BALB/MK-2 cells as a tracer. Phosphorus-32 69-72 interleukin 12b Mus musculus 81-84 34688150-5 2021 6-Gingerol combined with amphotericin B represented a safe mixture, extremely leishmanicidal, a potent antioxidant, induced a remarkable apoptotic index, significantly increased the expression of the Th1-related cytokines (IL-12p40, IFN-gamma, and TNF- alpha), iNOS, and transcription factors (STAT1, c-Fos, and Elk-1). gingerol 0-10 interleukin 12b Mus musculus 223-231 34348595-7 2021 TeEVs and KMP-11 could inhibit the productions of IL-12p40 and IFN-gamma, promote T. evansi proliferation and shorten the survival time of infected mice in vivo. kmp-11 10-16 interleukin 12b Mus musculus 50-58 34688150-5 2021 6-Gingerol combined with amphotericin B represented a safe mixture, extremely leishmanicidal, a potent antioxidant, induced a remarkable apoptotic index, significantly increased the expression of the Th1-related cytokines (IL-12p40, IFN-gamma, and TNF- alpha), iNOS, and transcription factors (STAT1, c-Fos, and Elk-1). Amphotericin B 25-39 interleukin 12b Mus musculus 223-231 34239908-5 2021 GL significantly (P < 0.05) increased secretion of inflammatory cytokines (IFN-gamma, IL-12p70, IL-6, and IL-10) in spleen and IL-12p40 mRNA expression in liver. Glycyrrhizic Acid 0-2 interleukin 12b Mus musculus 127-135 34311083-4 2021 Similarly, thioglycollate-elicited peritoneal cells isolated from wildtype mice treated with TP-064 showed lowered mRNA expression levels and cytokine production of pro-inflammatory mediators interleukin (IL)-1beta, IL-6, IL-12p40, and tumor necrosis factor-alpha in response to lipopolysaccharide exposure. Thioglycolates 11-25 interleukin 12b Mus musculus 222-230 34311083-4 2021 Similarly, thioglycollate-elicited peritoneal cells isolated from wildtype mice treated with TP-064 showed lowered mRNA expression levels and cytokine production of pro-inflammatory mediators interleukin (IL)-1beta, IL-6, IL-12p40, and tumor necrosis factor-alpha in response to lipopolysaccharide exposure. TP-064 93-99 interleukin 12b Mus musculus 222-230 35222366-11 2022 Mechanistically, adenosine receptor signals enhanced the association of AUF1s with the Vegfa, Il12b, and Tnf mRNAs to differentially regulate and facilitate the pro-angiogenic switch. Adenosine 17-26 interleukin 12b Mus musculus 94-99 34220460-6 2021 Reserpine-induced increases in plasma corticosterone concentrations were attenuated by the administration of FX and its components, which were also found to decrease the reserpine-induced enhancement of mRNA levels of interleukin (IL)-12 p40, IL-6, and tumor necrosis factor (TNF)-alpha, pro-inflammatory cytokines. Reserpine 0-9 interleukin 12b Mus musculus 218-241 34220460-6 2021 Reserpine-induced increases in plasma corticosterone concentrations were attenuated by the administration of FX and its components, which were also found to decrease the reserpine-induced enhancement of mRNA levels of interleukin (IL)-12 p40, IL-6, and tumor necrosis factor (TNF)-alpha, pro-inflammatory cytokines. Corticosterone 38-52 interleukin 12b Mus musculus 218-241 34220460-6 2021 Reserpine-induced increases in plasma corticosterone concentrations were attenuated by the administration of FX and its components, which were also found to decrease the reserpine-induced enhancement of mRNA levels of interleukin (IL)-12 p40, IL-6, and tumor necrosis factor (TNF)-alpha, pro-inflammatory cytokines. Reserpine 170-179 interleukin 12b Mus musculus 218-241 34367513-8 2021 The results showed that, asiaticoside stimulated the infected macrophages by stimulating increased production of TNF-alpha, IL-12 p40 and NO as well as increased expression of iNOS in a dose-dependent manner. asiaticoside 25-37 interleukin 12b Mus musculus 124-133 35538512-6 2022 Notably, molecular analysis of isolated tumor-infiltrating leukocytes following NI-1701 administration revealed an upregulation of genes linked to immune activation, including IFNgamma and IL-12b. ni-1701 80-87 interleukin 12b Mus musculus 189-195 35108365-0 2022 Glutamate in the medium of Lactiplantibacillus plantarum FL-664 affects the production of IL-12(p40) on murine spleen cells. Glutamic Acid 0-9 interleukin 12b Mus musculus 90-99 35108365-0 2022 Glutamate in the medium of Lactiplantibacillus plantarum FL-664 affects the production of IL-12(p40) on murine spleen cells. fl-664 57-63 interleukin 12b Mus musculus 90-99 35108365-4 2022 Addition of glutamate to the culture medium changes the size of LAB and affects their ability to induce IL-12(p40) production. Glutamic Acid 12-21 interleukin 12b Mus musculus 104-114 35059975-7 2022 In immunocompetent gp120tg+ mice, morphine increased the RNA expression of CCL2, CCL5, CXCL10, IL-12p40, and IFNbeta; while under the immunodeficient condition, morphine downregulated the expression of CCL2, CCL5, CXCL10, IL-12p40, and IL-1beta. Morphine 34-42 interleukin 12b Mus musculus 95-103 35163272-8 2022 After subcutaneous injection into mice, SA-CpG1668/tripodna induced significantly higher interleukin (IL)-12 p40 production in the draining lymph nodes than SA-CpG1668 or CpG1668/tripodna, with reduced IL-6 levels in plasma. sa-cpg1668 40-50 interleukin 12b Mus musculus 89-112 35163272-8 2022 After subcutaneous injection into mice, SA-CpG1668/tripodna induced significantly higher interleukin (IL)-12 p40 production in the draining lymph nodes than SA-CpG1668 or CpG1668/tripodna, with reduced IL-6 levels in plasma. tripodna 51-59 interleukin 12b Mus musculus 89-112 35059975-7 2022 In immunocompetent gp120tg+ mice, morphine increased the RNA expression of CCL2, CCL5, CXCL10, IL-12p40, and IFNbeta; while under the immunodeficient condition, morphine downregulated the expression of CCL2, CCL5, CXCL10, IL-12p40, and IL-1beta. Morphine 34-42 interleukin 12b Mus musculus 222-230 3084653-5 1986 The p32 precursor was rapidly processed by addition of high-mannose-containing core N-linked sugars to intracytoplasmic precursor intermediates of 38,000 (p38) and 40,000 (p40) daltons, which undergo further processing to yield a mature surface receptor with heterogeneous apparent m.w. Mannose 60-67 interleukin 12b Mus musculus 172-175 3133109-4 1988 Treatment with TPA in vivo resulted in about 2-fold increases in the phosphorylations of epidermal proteins with molecular weights of 34,000 and 40,000 and isoelectric points of 4.7-5.1 and 5.2-6.2 (p34 and p40, respectively). Tetradecanoylphorbol Acetate 15-18 interleukin 12b Mus musculus 207-210 3133109-6 1988 Inhibitors of PKC, such as chlorpromazine, quercetin, and staurosporine inhibited these increases in phosphorylations of p34 and p40 on TPA treatment. Chlorpromazine 27-41 interleukin 12b Mus musculus 129-132 3133109-6 1988 Inhibitors of PKC, such as chlorpromazine, quercetin, and staurosporine inhibited these increases in phosphorylations of p34 and p40 on TPA treatment. Quercetin 43-52 interleukin 12b Mus musculus 129-132 3133109-6 1988 Inhibitors of PKC, such as chlorpromazine, quercetin, and staurosporine inhibited these increases in phosphorylations of p34 and p40 on TPA treatment. Staurosporine 58-71 interleukin 12b Mus musculus 129-132 3133109-6 1988 Inhibitors of PKC, such as chlorpromazine, quercetin, and staurosporine inhibited these increases in phosphorylations of p34 and p40 on TPA treatment. Tetradecanoylphorbol Acetate 136-139 interleukin 12b Mus musculus 129-132 3084653-5 1986 The p32 precursor was rapidly processed by addition of high-mannose-containing core N-linked sugars to intracytoplasmic precursor intermediates of 38,000 (p38) and 40,000 (p40) daltons, which undergo further processing to yield a mature surface receptor with heterogeneous apparent m.w. n-linked sugars 84-99 interleukin 12b Mus musculus 172-175 33670766-8 2021 Immunohistochemical data showed a significant increase in TNF-alpha, alpha4beta7, VEGFRII, GR-1, CD25, CD3 and IL-12p40 expression in DSS mice if compared to controls. Dextran Sulfate 134-137 interleukin 12b Mus musculus 111-119 6547088-1 1984 p40, a mouse 1040-nucleotide cDNA clone encoding a form of phenobarbital-inducible cytochrome P-450b, was selected by probing a cDNA library derived from phenobarbital-treated DBA/2N mouse liver with a rat 1830-nucleotide cDNA probe complementary to P-450b mRNA. Phenobarbital 59-72 interleukin 12b Mus musculus 0-3 6547088-1 1984 p40, a mouse 1040-nucleotide cDNA clone encoding a form of phenobarbital-inducible cytochrome P-450b, was selected by probing a cDNA library derived from phenobarbital-treated DBA/2N mouse liver with a rat 1830-nucleotide cDNA probe complementary to P-450b mRNA. Phenobarbital 154-167 interleukin 12b Mus musculus 0-3 6547088-2 1984 When rat and mouse liver poly(A)+-enriched total RNAs are probed with p40, control rat P-450b mRNA levels are at least three times as much as control mouse P-450b levels. Poly A 25-33 interleukin 12b Mus musculus 70-73 32901588-4 2021 METHODS: A series of amide-containing DTTs were designed, synthesized, and assayed for ability to suppress proneuroinflammatory cytokines IL-12p40 and IL-23p19 induced by LPS in the BV2 microglial cell line. Amides 21-26 interleukin 12b Mus musculus 138-146 33368417-2 2021 IL-12p40 production induced by KT-11 was decreased in the presence of inhibitors of extracellular signal-regulated kinase or nuclear factor kappa B. kt-11 31-36 interleukin 12b Mus musculus 0-8 33368417-3 2021 Guanidine hydrochloride, urea or lithium chloride extract of KT-11 induced IL-12p40 production, but production was suppressed in the presence of Toll-like receptor 2-specific neutralizing antibody. Guanidine 0-23 interleukin 12b Mus musculus 75-83 33368417-3 2021 Guanidine hydrochloride, urea or lithium chloride extract of KT-11 induced IL-12p40 production, but production was suppressed in the presence of Toll-like receptor 2-specific neutralizing antibody. Urea 25-29 interleukin 12b Mus musculus 75-83 33368417-3 2021 Guanidine hydrochloride, urea or lithium chloride extract of KT-11 induced IL-12p40 production, but production was suppressed in the presence of Toll-like receptor 2-specific neutralizing antibody. Lithium Chloride 33-49 interleukin 12b Mus musculus 75-83 33368417-3 2021 Guanidine hydrochloride, urea or lithium chloride extract of KT-11 induced IL-12p40 production, but production was suppressed in the presence of Toll-like receptor 2-specific neutralizing antibody. kt-11 61-66 interleukin 12b Mus musculus 75-83 33461456-7 2022 CONCLUSION: These results suggest that EPA-PC is more effective in decreasing the expression of pro-inflammatory cytokines [IL-2, IFN-gamma, IL-6 and IL-12/IL-23(p40)] upon induction of inflammation. epa-pc 39-45 interleukin 12b Mus musculus 162-165 33263330-8 2020 Furthermore, a third successful implementation of the GlycoDelete technology focusing on murine IL-12B is shown to lead to N-glycosylation featuring an immature glycan in diffraction-quality crystals. Nitrogen 123-124 interleukin 12b Mus musculus 96-102 33263330-8 2020 Furthermore, a third successful implementation of the GlycoDelete technology focusing on murine IL-12B is shown to lead to N-glycosylation featuring an immature glycan in diffraction-quality crystals. Polysaccharides 161-167 interleukin 12b Mus musculus 96-102 33461456-5 2022 Moreover, treatment with EPA-PC and LPS significantly decreased IL-2, IL-6 and IL-12/IL-23(p40) expression (p < 0.01). epa-pc 25-31 interleukin 12b Mus musculus 91-94 32901588-4 2021 METHODS: A series of amide-containing DTTs were designed, synthesized, and assayed for ability to suppress proneuroinflammatory cytokines IL-12p40 and IL-23p19 induced by LPS in the BV2 microglial cell line. dtts 38-42 interleukin 12b Mus musculus 138-146 32333917-7 2020 This effect might be linked to capmatinib and DOX abilities to lower IL-12(p40) that has an inhibitory effect on IL-12(p70)/IFN-gamma-mediated apoptotic activity. Doxorubicin 46-49 interleukin 12b Mus musculus 75-78 32333917-7 2020 This effect might be linked to capmatinib and DOX abilities to lower IL-12(p40) that has an inhibitory effect on IL-12(p70)/IFN-gamma-mediated apoptotic activity. capmatinib 31-41 interleukin 12b Mus musculus 75-78 31548293-9 2020 GLPG1690 decreased irradiation-induced C-C motif chemokine ligand-11 in tumors and levels of IL9, IL12p40, macrophage colony-stimulating factor, and IFNgamma in adipose tissue adjacent to the tumor. GLPG1690 0-8 interleukin 12b Mus musculus 98-105 32528072-8 2020 Topical application of selective endothelin A receptor (ETAR) antagonist ambrisentan significantly attenuated the development of IMQ-induced psoriasiform dermatitis and also significantly inhibited the histological inflammation and cytokine expression (TNF-alpha, IL-12p40, IL-12 p19, and IL-17) in the lesional skin of the mouse model. ambrisentan 73-84 interleukin 12b Mus musculus 264-272 32084361-7 2020 (+)-Naltrexone suppressed the cPAF-induced expression of inflammatory cytokine genes, Il1b, Il6, and Il10 in the decidua, Il6, Il12b, and Il10 in the myometrium, and Il1b and Il6 in the placenta. Naltrexone 0-14 interleukin 12b Mus musculus 127-132 32084361-7 2020 (+)-Naltrexone suppressed the cPAF-induced expression of inflammatory cytokine genes, Il1b, Il6, and Il10 in the decidua, Il6, Il12b, and Il10 in the myometrium, and Il1b and Il6 in the placenta. 1-O-hexadecyl-2-N-methylcarbamylphosphatidylcholine 30-34 interleukin 12b Mus musculus 127-132 32279869-7 2020 Enhancement of IL-12p40 production in BMDMs was also observed when BMDMs were stimulated with CpG DNA ligated to oligodeoxynucleotides (ODNs) harboring 6 mA. Oligodeoxyribonucleotides 113-134 interleukin 12b Mus musculus 15-23 31121497-5 2019 This was accomplished by replacing the basic arginine (R) and lysine (K) residues in the cluster of amino acids 254-260 (RKKEKMK) of the murine IL-12 p40 subunit by the neutral non-polar amino acid alanine (A), generating an AAAEAMA mutant fusion protein. Arginine 45-53 interleukin 12b Mus musculus 144-153 31821337-11 2019 Pulmonary and splenic cytokine expression (TNF-alpha, GM-CSF) remained suppressed, while IL-12/p40 increased in mice administered alcohol 6 or 24 h prior to infection. Ethanol 130-137 interleukin 12b Mus musculus 95-98 31647039-6 2019 In the 0 02 %VC and wild-type groups, dexamethasone caused a significant decrease in the cluster of differentiation (CD)4+ and CD8+ T cells among splenocytes as well as a significant decrease in IL-2, IL-12p40 and interferon-gamma protein production by splenocytes and a significant decrease in T-cell proliferation among splenocytes. Dexamethasone 38-51 interleukin 12b Mus musculus 201-209 31614422-9 2019 Additionally, NT reduced levels of IL-13 and TNF-alpha in BALF and IL-17A, IL12p40, RANTES, mouse mast cell protease and malondialdehyde in lung homogenates. Neurotensin 14-16 interleukin 12b Mus musculus 75-82 31500303-5 2019 Wild type (WT) mice treated with poly(I:C) exhibited altered expression patterns of TNF and IL-12p40 during CASP which were dependent on IFNbeta or IFNAR1, suggesting a mechanism for the increased sepsis susceptibility of WT mice. Poly I-C 33-42 interleukin 12b Mus musculus 92-100 31121497-5 2019 This was accomplished by replacing the basic arginine (R) and lysine (K) residues in the cluster of amino acids 254-260 (RKKEKMK) of the murine IL-12 p40 subunit by the neutral non-polar amino acid alanine (A), generating an AAAEAMA mutant fusion protein. Arginine 55-56 interleukin 12b Mus musculus 144-153 31121497-5 2019 This was accomplished by replacing the basic arginine (R) and lysine (K) residues in the cluster of amino acids 254-260 (RKKEKMK) of the murine IL-12 p40 subunit by the neutral non-polar amino acid alanine (A), generating an AAAEAMA mutant fusion protein. Lysine 62-68 interleukin 12b Mus musculus 144-153 31121497-5 2019 This was accomplished by replacing the basic arginine (R) and lysine (K) residues in the cluster of amino acids 254-260 (RKKEKMK) of the murine IL-12 p40 subunit by the neutral non-polar amino acid alanine (A), generating an AAAEAMA mutant fusion protein. Alanine 198-205 interleukin 12b Mus musculus 144-153 30580570-10 2019 Depletion of macrophages in IL12p40-/- mice by clodronate liposomes significantly decreased the maximal external diameter of aorta and aortic stiffness in response to Ang II as determined by imaging and atomic force microscopy. Clodronic Acid 47-57 interleukin 12b Mus musculus 28-35 31283217-3 2019 Systemically, PIP2 inhibits the lipopolysaccharide (LPS)-elicited TNF-alpha, IL-6, and IL-12p40 in a mouse model. Phosphatidylinositol 4,5-Diphosphate 14-18 interleukin 12b Mus musculus 87-95 31293572-3 2019 Tunicamycin (Tm) treatment of bone marrow derived macrophages (BMDM) cultured with M-CSF cultured bone marrow derived macrophages (M-BMDM) had markedly amplified M1-like responses to LPS, exhibiting higher levels of IL12p40 and IL12p35 mRNAs while BMDM cultured with GM-CSF, which normally express high IL12 subunit production in response to LPS, were relatively unaltered. Tunicamycin 0-11 interleukin 12b Mus musculus 216-223 31293572-3 2019 Tunicamycin (Tm) treatment of bone marrow derived macrophages (BMDM) cultured with M-CSF cultured bone marrow derived macrophages (M-BMDM) had markedly amplified M1-like responses to LPS, exhibiting higher levels of IL12p40 and IL12p35 mRNAs while BMDM cultured with GM-CSF, which normally express high IL12 subunit production in response to LPS, were relatively unaltered. Tunicamycin 13-15 interleukin 12b Mus musculus 216-223 31009850-12 2019 Bavachin also reduced LPS-induced IL-6 and IL-12p40 production and decreased the activation of MAPKs and NF-kappaB. bavachin 0-8 interleukin 12b Mus musculus 43-51 31009850-14 2019 Furthermore, bavachin also suppressed the production of NO, IL-6 and IL-12p40 by LPS-stimulated murine peritoneal macrophages. bavachin 13-21 interleukin 12b Mus musculus 69-77 31178861-7 2019 Macrophages from mice treated with FHTE expressed markers of AAM and had heightened IL-10 and IL-1RA production in response to FHTE or TLR ligands and had suppressed TNF and IL-12p40 production. fhte 35-39 interleukin 12b Mus musculus 174-182 29881422-4 2018 The zymosan-mediated secretion of tumor necrosis factor-alpha (TNF)-alpha), interleukin (IL)-6), and IL12p40 but not IL-10 in BMDMs was significantly inhibited by pre-treatment with wedelolactone (30 microg/mL, P < 0.001). Zymosan 4-11 interleukin 12b Mus musculus 101-108 29753267-0 2018 The localisation of the heparin binding sites of human and murine interleukin-12 within the carboxyterminal domain of the P40 subunit. Heparin 24-31 interleukin 12b Mus musculus 122-125 29753267-4 2018 Heparin markedly protects the human and murine p40 subunits, but not the p35 subunits, from cleavage by the bacterial endoprotease LysC, further implicating the larger subunit as the location of the heparin binding site. Heparin 0-7 interleukin 12b Mus musculus 47-50 30216978-4 2018 We showed that ArtinM activates murine B cells, increasing IL-17 and IL-12p40 production. artinm 15-21 interleukin 12b Mus musculus 69-77 29788053-2 2018 We reported that mouse p40 peptide-based vaccines ameliorated intestinal inflammation in the prevention of trinitrobenzene sulfonic acid (TNBS)-induced murine colitis model. Trinitrobenzenesulfonic Acid 107-136 interleukin 12b Mus musculus 23-26 29788053-2 2018 We reported that mouse p40 peptide-based vaccines ameliorated intestinal inflammation in the prevention of trinitrobenzene sulfonic acid (TNBS)-induced murine colitis model. Trinitrobenzenesulfonic Acid 138-142 interleukin 12b Mus musculus 23-26 29193138-10 2018 Furthermore, IL-12p40 production by DCs was induced by PC-KLH in a dose-dependent manner. pc-klh 55-61 interleukin 12b Mus musculus 13-21 29973940-7 2018 Activation of the GPR84 receptor with a selective agonist, 6-(octylamino) pyrimidine-2,4(1H,3H)-dione (6-n-octylaminouracil, 6-OAU), enhanced the expression of phosphorylated Akt, p-ERK, and p65 nuclear translocation under inflammatory conditions and elevated the expression levels of the inflammatory mediators TNFalpha, IL-6, IL-12B, CCL2, CCL5, and CXCL1. 6-(octylamino) pyrimidine-2,4(1h,3h)-dione 59-101 interleukin 12b Mus musculus 328-334 29544684-8 2018 We found that p40 mAb suppressed epidermal thickness and increased transepidermal water loss (TEWL) as indicator for skin barrier function with accompanying suppression of IL-23p19, IL-17A, IL-22, and keratin 16 gene expression. Water 82-87 interleukin 12b Mus musculus 14-17 29127663-7 2018 Consistent with this, inflammatory cytokines including TNFalpha, IL-12p40, IFNgamma, and MCP-1 were enhanced both systemically and locally in the poly(I:C)-treated group compared to the vehicle control. poly 146-150 interleukin 12b Mus musculus 65-73 29414653-3 2018 Eight genes Ltf, Tnf, Il6, Jun, Il12b, Stat3, Rel and Crem could regulate the inflammatory factors, and TNF signaling pathway and Jak-STAT signaling pathway might play an important role in the mechanism through which DECB protected the liver of mice. decb 217-221 interleukin 12b Mus musculus 32-37 28870465-6 2018 The IMQ-induced upregulation of Il12b and Il23a was marked in the epidermis and was abrogated by CAL application, suggesting CAL-mediated suppression of IL-23 expression. Imiquimod 4-7 interleukin 12b Mus musculus 32-37 27997959-9 2017 This modulation may be related to the lower levels of IL-12p40 and IL-6 after treatment with parthenolide. parthenolide 93-105 interleukin 12b Mus musculus 54-62 28742108-6 2017 Glucose-deprivation by 2-deoxy-D-glucose (2-DG) increased the production of IL-12p40 and IL-23p19 in monocytes, but dose-dependently inhibited the release of anti-inflammatory IL-10. Deoxyglucose 23-40 interleukin 12b Mus musculus 76-84 28742108-6 2017 Glucose-deprivation by 2-deoxy-D-glucose (2-DG) increased the production of IL-12p40 and IL-23p19 in monocytes, but dose-dependently inhibited the release of anti-inflammatory IL-10. Deoxyglucose 42-46 interleukin 12b Mus musculus 76-84 29061708-8 2018 Infected, trimannose-treated mice had decreased IL-12p40 and IL-10 secretion and increased interferon gamma secretion at 14 days p.i. trimannose 10-20 interleukin 12b Mus musculus 48-56 27449383-7 2016 RESULTS: AZM significantly inhibited the expression of co-stimulatory molecules (CD40 and CD80) and reduced TNF-alpha, IL-10, IL-12p40, IL-12p70, IL-23p19 in BMDCs and IFN-alpha production in plasmacytoid DCs. Azithromycin 9-12 interleukin 12b Mus musculus 126-134 28265547-8 2017 RESULTS: In PBS-treated EAE mice, the expression of IL-12 P35 and IL-12 P40 mRNA in the CNS and the mean serum levels of IL-12 were significantly higher than those of healthy group (p<0.001). Lead 12-15 interleukin 12b Mus musculus 66-75 27563010-3 2016 Serum from mice immunized with rH-NS with or without adjuvant also had higher levels of IL-12p40 and TNF-alpha, compared with those from control mice immunized with phosphate-buffered saline. rh-ns 31-36 interleukin 12b Mus musculus 88-96 27563010-5 2016 We found that rH-NS induced the production of TNF-alpha, IL-6, and IL-12p40, which relied on the activation of mitogen-activated protein kinases by stimulating the rapid phosphorylation of ERK1/2, p38, and JNK, and on the activation of transcription factor NF-kappaB in macrophages. rh-ns 14-19 interleukin 12b Mus musculus 67-75 27554194-4 2016 Exogenous PAF inhibited the production of pro-inflammatory cytokines (IL-12p40, IL-6, and TNF-alpha) and increased anti-inflammatory IL-10 in macrophages challenged with Pam3Cys and LPS, but not with Poly (I:C). Platelet Activating Factor 10-13 interleukin 12b Mus musculus 70-78 27515704-3 2016 The corresponding fusion protein (F8-IL12p40), which inhibits colitis development in mice, is a glycosylated protein with suboptimal disease targeting properties in vivo Since the protein was extensively glycosylated, as evidenced by PNGase F treatment and mass spectrometric analysis, we mutated four asparagine residues in various combinations. Asparagine 302-312 interleukin 12b Mus musculus 37-44 26793623-7 2015 Poly I:C induced IFN-gamma expression by NK cells in the MLN, which was mediated through type I IFNs and IL-12p40 from antigen presenting cells and consequent activation of STAT1 and STAT4 in NK cells. Poly I-C 0-8 interleukin 12b Mus musculus 105-113 27091926-7 2016 Increasing the infectious dose of LAC to 10(5) CFU negated these differences in IL-12p40 knockout animals, demonstrating the importance of bacterial inoculum on infection outcome. Lactose 34-37 interleukin 12b Mus musculus 80-88 27001378-2 2016 Here, we performed phenotypic screening in IFNgamma/LPS-activated RAW264.7, mouse macrophage cells, and discovered AS2677131 and AS2795440 as novel and potent inhibitors of IL-12p40, a subunit of IL-23. as2677131 115-124 interleukin 12b Mus musculus 173-181 27001378-2 2016 Here, we performed phenotypic screening in IFNgamma/LPS-activated RAW264.7, mouse macrophage cells, and discovered AS2677131 and AS2795440 as novel and potent inhibitors of IL-12p40, a subunit of IL-23. as2795440 129-138 interleukin 12b Mus musculus 173-181 27001378-6 2016 Regarding mechanism, AS2677131 regulated DNA binding activity of c-Rel on IL-12p40 and IL-1beta promoter. as2677131 21-30 interleukin 12b Mus musculus 74-82 26614407-6 2016 At the molecular level, we demonstrated that the Aldara-induced mRNA expression of the psoriasis-related inflammatory markers interleukin (IL)-17C, IL-23p19, IL-12p40, IL-17A, IL-22 and S100A8 was significantly decreased in TNF-alpha KO mice compared with WT mice. Imiquimod 49-55 interleukin 12b Mus musculus 158-166 26842661-8 2016 RESULTS Haloperidol inhibited NF-kappaB activation, and thereby suppressed expression of CD80, as well as secretion of IL-1beta, IL-6, and IL-12 p40. Haloperidol 8-19 interleukin 12b Mus musculus 145-148 26728370-8 2016 Furthermore, beta-glucan could prompt BMDCs to secret high levels of IL-6, TNF-alpha, IL-12 p40 and increase the production of CCR7 mRNA. beta-Glucans 13-24 interleukin 12b Mus musculus 86-95 26406561-8 2016 Inhibition of SUV39H1 with chaetocin in NG-treated macrophages also increased the expression of IL-6, IL-12p40, MIP-1alpha, and MIP-1beta. chaetocin 27-36 interleukin 12b Mus musculus 102-110 25019567-9 2014 rTB10.4-induced TNF-alpha, IL-6 and IL-12 p40 release was attenuated by the specific IkappaB phosphorylation inhibitor, BAY 11-7082. 3-(4-methylphenylsulfonyl)-2-propenenitrile 120-131 interleukin 12b Mus musculus 36-45 25701315-9 2015 Cytokine and chemokine secretion in the serum of DNV-immunized mice showed elevated levels of IFN-gamma, IL-2, IL-5, IL-12p40, IL-12p70, IL-17, eotaxin and RANTES, all of which have varying immune functions. 2-{(S)-(2-chlorophenyl)[2-(1-methyl-1H-imidazol-2-yl)ethoxy]methyl}-1H-pyrrolo[3,2-b]pyridine-7-carboxylic acid 49-52 interleukin 12b Mus musculus 117-125 25548274-7 2015 Thus, LREL-induced increases in the expression levels of several cell surface marker proteins, production of inflammatory cytokines IL-12p40 and TNF-alpha, and activation and nuclear translocation of transcription factors, as was observed in the WT DCs, were completely abrogated in DCs derived from the TLR4(-/-) mice but not in DCs derived from the TLR2(-/-), TLR7(-/-), and TLR9(-/-) mice. lrel 6-10 interleukin 12b Mus musculus 132-140 25146842-8 2015 LPMCs were isolated from IL-10(-/-) mice, and cellular expression of IL-12p40 and interferon-gamma was suppressed by fluoxetine treatment. lpmcs 0-5 interleukin 12b Mus musculus 69-77 25146842-8 2015 LPMCs were isolated from IL-10(-/-) mice, and cellular expression of IL-12p40 and interferon-gamma was suppressed by fluoxetine treatment. Fluoxetine 117-127 interleukin 12b Mus musculus 69-77 25146842-9 2015 Fluoxetine significantly inhibited IL-12p40 and TNF-alpha gene expression and protein secretion in BMDCs from IL-10(-/-) mice. Fluoxetine 0-10 interleukin 12b Mus musculus 35-43 26522348-5 2015 RESULTS: Pam3CSK4, R848 and CpG oligodeoxynucleotide (ODN) promoted the production of IL-12p40 and IL-6 by splenocytes and dendritic cells obviously, and induced the expression of IFN-gamma in antigen specific CD4+ T cells in a time- and dose-dependent manner. Oligodeoxyribonucleotides 32-52 interleukin 12b Mus musculus 86-94 26522348-5 2015 RESULTS: Pam3CSK4, R848 and CpG oligodeoxynucleotide (ODN) promoted the production of IL-12p40 and IL-6 by splenocytes and dendritic cells obviously, and induced the expression of IFN-gamma in antigen specific CD4+ T cells in a time- and dose-dependent manner. Oligodeoxyribonucleotides 54-57 interleukin 12b Mus musculus 86-94 26522348-6 2015 Monophosphoryl lipid A from Salmonella minnesota R595 lipopolysaccharide (MPLA-SM) induced low levels of cytokines by splenocytes and couldn"t promote the production of IFN-gamma by antigen specific CD4+ T cells, but increased the expressions of IL-12p40 and IL-6 by DCs. monophosphoryl lipid A 0-22 interleukin 12b Mus musculus 246-254 26522348-6 2015 Monophosphoryl lipid A from Salmonella minnesota R595 lipopolysaccharide (MPLA-SM) induced low levels of cytokines by splenocytes and couldn"t promote the production of IFN-gamma by antigen specific CD4+ T cells, but increased the expressions of IL-12p40 and IL-6 by DCs. mpla-sm 74-81 interleukin 12b Mus musculus 246-254 25987561-4 2015 BMDM from low fat-fed mice exposed to palmitate (PA) for 18 h ex vivo also showed elevated expression of proinflammatory genes (Cxcl1, Il6, Tnf, Nos2, and Il12b) associated with M1 polarization. Palmitates 38-47 interleukin 12b Mus musculus 155-160 25987561-4 2015 BMDM from low fat-fed mice exposed to palmitate (PA) for 18 h ex vivo also showed elevated expression of proinflammatory genes (Cxcl1, Il6, Tnf, Nos2, and Il12b) associated with M1 polarization. Palmitates 49-51 interleukin 12b Mus musculus 155-160 25911755-7 2015 Double knockout mice lacking both receptors showed superior protection to Aldara in comparison with the single knockout mice and displayed reduced levels of IL-12p40, IL-17F, and S100A8, indicating that the TNF and type I IFN pathways contribute significantly to inflammation upon treatment with Aldara. Imiquimod 296-302 interleukin 12b Mus musculus 157-165 24818707-8 2014 Conversely, adding 1400W to J774.1 cells further enhanced IL-12p40 production, suggesting that IL-12 production is perturbed by excess endogenous NO. N-((3-(aminomethyl)phenyl)methyl)ethanimidamide 19-24 interleukin 12b Mus musculus 58-66 25259790-6 2014 p35 and p40 but not p35 and EBI3 form an inter-chain disulfide bridge. Disulfides 53-62 interleukin 12b Mus musculus 8-11 25612451-9 2014 The glycyrrhizin acid significantly inhibited IL-1beta, IL-3, IL-5, IL-6, IL-10, IL-12 (p40), IL-12 (p70), IL-13, Eotaxin and TNF-alpha secreted by LPS-stimulated RAW264.7 cells (P < 0.05). glycyrrhizin acid 4-21 interleukin 12b Mus musculus 88-91 24794016-8 2014 Furthermore, in a murine model of endotoxic shock, treatment with CLA suppressed LPS-induced induction of circulating IFN-gamma, IL-12p40 and IL-1beta. Linoleic Acids, Conjugated 66-69 interleukin 12b Mus musculus 129-137 25057822-9 2014 However, Delta9-THC significantly suppressed IL-12p70 and IL-12p40 as well as marginally suppressed IL-17 versus vehicle treated mice. Dronabinol 9-19 interleukin 12b Mus musculus 58-66 24189499-4 2014 Cytokine assay suggested that the SSZ-FUCO-PPID potentially inhibited the IL-12 p40 production in LPS activated macrophages. ssz-fuco-ppid 34-47 interleukin 12b Mus musculus 74-83 23780918-7 2013 IFN-gamma, MCP-1, and IL-12p40 concentrations from lymphocytes of mesenteric lymph nodes were highest in O3H mice, compared to O3O6 and O6H mice. CHEMBL4460557 105-108 interleukin 12b Mus musculus 22-30 23882124-3 2013 Treatment with 300 muM nicotinic acid (reported EC50 3 muM, peak plasma concentration 50-300 muM), significantly inhibited TNF-alpha, IL-6, IL-12p40, and IL-1beta production (P<0.05) in LPS (1 ng/ml)-stimulated wild-type murine bone marrow-derived macrophages (BMMs) but failed to do so in Hca2(-/-) BMMs. Niacin 23-37 interleukin 12b Mus musculus 140-148 24684892-10 2014 Sub-acute exposure to ZnO NPs caused an increase of macrophages in BAL fluid and a moderate increase in IL-12(p40) and MIP-1alpha, but no other inflammatory or toxic responses were observed. Zinc Oxide 22-25 interleukin 12b Mus musculus 110-113 23615706-8 2013 In addition, STZ alone promoted a marked decrease in the levels of several circulating cytokines, including interleukin-12 (IL-12)p40. Streptozocin 13-16 interleukin 12b Mus musculus 124-133 23615706-9 2013 On the other hand, co-injection of STZ + Nutlin-3 significantly (p < 0.01) counteracted IL-12p40 down-modulation. Streptozocin 35-38 interleukin 12b Mus musculus 91-99 23615706-9 2013 On the other hand, co-injection of STZ + Nutlin-3 significantly (p < 0.01) counteracted IL-12p40 down-modulation. nutlin 3 41-49 interleukin 12b Mus musculus 91-99 24028683-7 2013 The TFA diet significantly elevated interleukin (IL)-6, IL-12p40, IL-23p19 and retinoic acid-related orphan receptor (ROR)gammat mRNA levels in the colons of DSS-treated animals. Trans Fatty Acids 4-7 interleukin 12b Mus musculus 56-64 23716000-6 2013 Supplement with recombinant mouse IL-12b or restoration of IL-12b expression in the host by zoledronic acid, which was previously reported to enhance IL-12 expression in vitro and in vivo, alleviated the metastasis-promoting effects of sunitinib and sorafenib. Zoledronic Acid 92-107 interleukin 12b Mus musculus 59-65 23716000-6 2013 Supplement with recombinant mouse IL-12b or restoration of IL-12b expression in the host by zoledronic acid, which was previously reported to enhance IL-12 expression in vitro and in vivo, alleviated the metastasis-promoting effects of sunitinib and sorafenib. Sunitinib 236-245 interleukin 12b Mus musculus 34-40 23716000-6 2013 Supplement with recombinant mouse IL-12b or restoration of IL-12b expression in the host by zoledronic acid, which was previously reported to enhance IL-12 expression in vitro and in vivo, alleviated the metastasis-promoting effects of sunitinib and sorafenib. Sunitinib 236-245 interleukin 12b Mus musculus 59-65 23716000-6 2013 Supplement with recombinant mouse IL-12b or restoration of IL-12b expression in the host by zoledronic acid, which was previously reported to enhance IL-12 expression in vitro and in vivo, alleviated the metastasis-promoting effects of sunitinib and sorafenib. Sorafenib 250-259 interleukin 12b Mus musculus 34-40 23716000-6 2013 Supplement with recombinant mouse IL-12b or restoration of IL-12b expression in the host by zoledronic acid, which was previously reported to enhance IL-12 expression in vitro and in vivo, alleviated the metastasis-promoting effects of sunitinib and sorafenib. Sorafenib 250-259 interleukin 12b Mus musculus 59-65 23101887-7 2013 Mannans lacking the beta-1,2-mannosides induced the production of higher levels of inflammatory cytokines, including IL-6, IL-12p40 and TNF-alpha, in mice dendritic cells compared to wild-type mannan. Mannans 0-7 interleukin 12b Mus musculus 123-131 24062633-8 2013 After exposure to IL-4/LPS BTBR macrophages produced less IL-10 (p < 0.01) than C57 macrophages and more IL-12p40 (p < 0.01) suggesting poor M2 polarization. btbr 27-31 interleukin 12b Mus musculus 108-116 23850963-4 2013 Our results show that TAMs downregulate IL-12p70 but upregulate IL-12p40, IL-23, IL-6 and IL-10. tams 22-26 interleukin 12b Mus musculus 64-72 22576253-2 2013 Furthermore, deletion of the gene encoding interleukin (IL)-12p40 resulted in a strain (IL-12p40(-/-) dnTGFbetaRII) with dramatically reduced autoimmune cholangitis. dntgfbetarii 102-114 interleukin 12b Mus musculus 43-65 22576253-2 2013 Furthermore, deletion of the gene encoding interleukin (IL)-12p40 resulted in a strain (IL-12p40(-/-) dnTGFbetaRII) with dramatically reduced autoimmune cholangitis. dntgfbetarii 102-114 interleukin 12b Mus musculus 88-96 23536773-0 2013 Molecules altering the intracellular thiol content modulate NF-kB and STAT-1/IRF-1 signalling pathways and IL-12 p40 and IL-27 p28 production in murine macrophages. Sulfhydryl Compounds 37-42 interleukin 12b Mus musculus 107-116 23099324-5 2013 GW3965 was able to repress proinflammatory cytokine (TNF-alpha, IL-1beta, IL-6, and IL-12p40) expression in BMMs exposed to LPS alone; however, once BMMs entered the osteoclast lineage following RANKL priming, GW3965 no longer inhibited cytokine expression. GW 3965 0-6 interleukin 12b Mus musculus 84-92 23536773-5 2013 The protein production of IL-12 p40 was increased by GSH-C4 and decreased by I-152 as determined by Enzyme-linked immunosorbent assay. Glutathione 53-56 interleukin 12b Mus musculus 26-35 23781267-10 2013 Artepillin C exerted strong antioxidant activity, significantly inhibited the production of ROS, RNS, NO, and cytokine IL-1 beta , IL-3, IL-4, IL-5, IL-9, IL-12p40, IL-13, IL-17, TNF- alpha , G-CSF, GM-CSF, MCP-1, MIP-1 alpha , MIP-1 beta , RANTES, and KC, and markedly blocked NF- kappa B expression in stimulated RAW264.7 macrophages. artepillin C 0-12 interleukin 12b Mus musculus 155-163 23533666-8 2013 We further show that the reduction in IL-10 production in the MSK1/2 macrophages results in increased secretion of IL-12p40 in response to zymosan relative to wild type controls. Zymosan 139-146 interleukin 12b Mus musculus 115-123 23536773-4 2013 Under these experimental conditions, GSH-C4 and I-152 enhanced and suppressed respectively the mRNA expression levels of IL-12 p40 induced by LPS/IFN-gamma as assessed by Real-Time PCR. Glutathione 37-40 interleukin 12b Mus musculus 121-130 23212638-0 2012 Enhanced IL-12p40 production in LPS-stimulated macrophages by inhibiting JNK activation by artemisinin. artemisinin 91-102 interleukin 12b Mus musculus 9-17 23212638-2 2012 In this study, we investigated the effect of artemisinin on the production of IL-12p40, which is important in the generation of T helper 1 responses. artemisinin 45-56 interleukin 12b Mus musculus 78-86 23212638-3 2012 Artemisinin significantly induced IL-12p40 production in LPS-stimulated RAW264.7 macrophage cells. artemisinin 0-11 interleukin 12b Mus musculus 34-42 23212638-4 2012 To elucidate the signaling molecules regulated by artemisinin in induced IL-12p40 production, the DNA-binding activity of several transcription factors and activation of mitogen-activated protein kinase (MAPK)s were investigated. artemisinin 50-61 interleukin 12b Mus musculus 73-81 23212638-7 2012 Taken together, these data suggest that artemisinin induces the production of IL-12p40 in LPS-stimulated macrophage cells by inhibiting JNK activity. artemisinin 40-51 interleukin 12b Mus musculus 78-86 22570747-4 2012 RESULTS: EGCG inhibited accumulation of LPS-induced IL-12p40, IL-6, MCP-1, ICAM-1, and VCAM-1 mRNA in BMMs. epigallocatechin gallate 9-13 interleukin 12b Mus musculus 52-60 22463790-10 2012 Addition of exogenous tumor necrosis factor (TNF) alpha only partially rescued the expression of il12p40 in the presence of GSI. 2-(5-Chlorothiophen-2-Yl)-N-[(3s)-1-(4-{2-[(Dimethylamino)methyl]-1h-Imidazol-1-Yl}-2-Fluorophenyl)-2-Oxopyrrolidin-3-Yl]ethanesulfonamide 124-127 interleukin 12b Mus musculus 97-104 22936807-7 2012 Lymph node cells from mice treated with p28/p40 blocked adoptive transfer of EAU to naive syngeneic mice by immunopathogenic T cells and suppressive effects of p28/p40 derived in part from antagonizing STAT1 and STAT3 pathways induced by IL-27 and IL-6. Water 77-80 interleukin 12b Mus musculus 44-47 22684115-4 2012 The enhanced expression of MHC II and CD40 on DCs after incubation with amphiphilic polyanhydride particles, and the increased secretion of IL-6, TNF-alpha, and IL-12p40 by hydrophobic polyanhydride particles exemplified the chemistry-dependent activation of DCs by sham-coated particles. Polyanhydrides 185-198 interleukin 12b Mus musculus 161-169 22766077-6 2012 Further comparison revealed that in LPS-stimulated J774A.1 cells, the cPLA2 inhibitor showed the same profile of inhibition as azithromycin in inhibiting PGE2, IL-6, IL-12p40 and arachidonic acid release. Azithromycin 127-139 interleukin 12b Mus musculus 166-174 22917537-5 2012 Resveratrol also suppressed astrocyte production of IL-12p40 and IL-23, which are known to alter the phenotype of T cells involved in adaptive immunity. Resveratrol 0-11 interleukin 12b Mus musculus 52-60 22570747-8 2012 U0126 (an inhibitor of MEK-1/2) suppressed the LPS-induced IL-12p40, IL-6, MCP-1, ICAM-1, and VCAM-1 mRNA accumulation in BMMs. U 0126 0-5 interleukin 12b Mus musculus 59-67 22479554-5 2012 Treatment of bone marrow derived macrophages (BMDMs) with tacrolimus or 11R-VIVIT significantly inhibited LPS and LPS plus IFN-gamma induced IL-12 p40 mRNA and protein expression. Tacrolimus 58-68 interleukin 12b Mus musculus 141-150 22215650-9 2012 Tunicamycin significantly upregulated IL-12p40 expression in adipocytes, and IL-12 addition increased ER stress gene expression; conversely, LSF, an IL-12 signaling inhibitor, and an IL-12p40-neutralizing antibody attenuated tunicamycin-induced ER stress. Tunicamycin 0-11 interleukin 12b Mus musculus 38-46 22215650-9 2012 Tunicamycin significantly upregulated IL-12p40 expression in adipocytes, and IL-12 addition increased ER stress gene expression; conversely, LSF, an IL-12 signaling inhibitor, and an IL-12p40-neutralizing antibody attenuated tunicamycin-induced ER stress. Tunicamycin 225-236 interleukin 12b Mus musculus 183-191 22174456-4 2012 We demonstrated that rMPT83 induced the production of TNF-alpha, IL-6, and IL-12 p40 and that cytokine induction depended on activated MAPKs, because we observed the rapid phosphorylation of ERK1/2, p38, and JNK in macrophages. rmpt83 21-27 interleukin 12b Mus musculus 75-84 21778411-2 2012 Exposure of mice to acrolein at concentrations similar to those in cigarette smoke (5 ppm, 4 h) significantly suppressed alveolar macrophage responses to bacterial LPS, indicated by reduced induction of nitric oxide synthase 2, TNF-alpha, and IL-12p40. Acrolein 20-28 interleukin 12b Mus musculus 243-251 22189654-7 2012 Bindarit inhibits the LPS-induced MCP-1 and IL-12beta/p40 expression without affecting other analyzed cytokines. bindarit 0-8 interleukin 12b Mus musculus 44-53 22189654-7 2012 Bindarit inhibits the LPS-induced MCP-1 and IL-12beta/p40 expression without affecting other analyzed cytokines. bindarit 0-8 interleukin 12b Mus musculus 54-57 22479554-5 2012 Treatment of bone marrow derived macrophages (BMDMs) with tacrolimus or 11R-VIVIT significantly inhibited LPS and LPS plus IFN-gamma induced IL-12 p40 mRNA and protein expression. 11R-VIVIT 72-81 interleukin 12b Mus musculus 141-150 21575254-8 2011 RESULTS: OMC suppressed LPS-induced secretion of tumor necrosis factor-alpha (TNF-alpha, interleukin-6 (IL-6), and IL-12p40 from RAW264.7 macrophages. lps 24-27 interleukin 12b Mus musculus 115-123 22427889-9 2012 Surprisingly, p105DeltaNS930A retained inhibitory activity for Il12b, indicating that ERK activation was not necessary for inhibition. p105deltans930a 14-29 interleukin 12b Mus musculus 63-68 21683614-7 2011 Gene expression analysis showed that salbutamol inhibited the p40 subunit as well as IL-12p35, while IL-23p19 and IL-6 were stimulated. Albuterol 37-47 interleukin 12b Mus musculus 62-65 21730055-0 2011 Morphine withdrawal stress modulates lipopolysaccharide-induced interleukin 12 p40 (IL-12p40) expression by activating extracellular signal-regulated kinase 1/2, which is further potentiated by glucocorticoids. Morphine 0-8 interleukin 12b Mus musculus 64-82 21730055-0 2011 Morphine withdrawal stress modulates lipopolysaccharide-induced interleukin 12 p40 (IL-12p40) expression by activating extracellular signal-regulated kinase 1/2, which is further potentiated by glucocorticoids. Morphine 0-8 interleukin 12b Mus musculus 84-92 21730055-8 2011 ERK inhibitors reversed MW and MW plus corticosterone inhibition of LPS-induced IL-12p40. Corticosterone 39-53 interleukin 12b Mus musculus 80-88 21439412-7 2011 In addition, microparticle stimulation of DCs also enhanced secretion of the cytokines IL-12p40 and IL-6, a phenomenon found to be dependent on polymer chemistry. Polymers 144-151 interleukin 12b Mus musculus 87-95 21039629-6 2011 These EtOH-exposed DCs, after activation by CpG or tumor necrosis factor alpha (TNFalpha), were less able to upregulate costimulatory molecules CD40, CD80, or CD86, and produced less IL-12 p40, TNFalpha, and IFNalpha than DCs from water-fed mice. Ethanol 6-10 interleukin 12b Mus musculus 189-192 21321105-2 2011 Previous work indicated that a region on chromosome 11 encoding the IL-12p40 subunit regulates strain differences in susceptibility to murine trinitrobenzene sulfonic acid-induced colitis. Trinitrobenzenesulfonic Acid 142-171 interleukin 12b Mus musculus 68-76 21081706-9 2011 Sitagliptin also reduced adipocyte mRNA expression of inflammatory genes, including IL-6, TNFalpha, IL-12(p35), and IL-12(p40), 2.5- to fivefold as well as 12-lipoxygenase protein expression. Sitagliptin Phosphate 0-11 interleukin 12b Mus musculus 122-125 21081706-11 2011 Sitagliptin significantly reduced mRNA expression of the following inflammatory cytokines: MCP-1 (3.3-fold), IL-6 (2-fold), IL-12(p40) (2.2-fold), IL-12(p35) (5-fold, P < 0.01), and IP-10 (2-fold). Sitagliptin Phosphate 0-11 interleukin 12b Mus musculus 130-133 21075976-1 2011 The inhibition of UVB-induced immunosuppression by dietary grape seed proanthocyanidins (GSP) has been associated with the induction of interleukin (IL)-12 in mice, and we now confirm that GSPs do not inhibit UVB-induced immunosuppression in IL-12p40 knockout (IL-12 KO) mice and that treatment of these mice with recombinant IL-12 restores the inhibitory effect. Grape Seed Proanthocyanidins 89-92 interleukin 12b Mus musculus 242-250 21424108-0 2011 Targeting IL-12/IL-23 by employing a p40 peptide-based vaccine ameliorates TNBS-induced acute and chronic murine colitis. Trinitrobenzenesulfonic Acid 75-79 interleukin 12b Mus musculus 37-40 21135031-3 2011 Intra nasal delivery of 50 mug GL into the lung of naive Balb/c mice induced FoxP3 expression locally and IL-10 production and IL-12p40 in RNA expression in the airways in vivo. galiellalactone 31-33 interleukin 12b Mus musculus 127-135 21424108-8 2011 After administrations of TNBS, vaccinated mice had significantly less body weight loss and a significant decrease of inflammatory scores, collagen deposition and expression of p40, IL-12, IL-23, IL-17, TNF, iNOS and Bcl-2 in colon tissues, compared with carrier and saline groups. Trinitrobenzenesulfonic Acid 25-29 interleukin 12b Mus musculus 176-179 21078906-4 2010 In this study, we demonstrate that MSP inhibits LPS-induced IL-12p40 expression, and this inhibition is dependent on the docking site tyrosines in Ron. Tyrosine 134-143 interleukin 12b Mus musculus 60-68 20826012-4 2010 Treatment with the transcriptional activator retinoic acid (RA) suppressed mRNA expression and protein release of several important cytokines (IL-1beta 4%, IL-6 21%, TNFalpha 30%, IL-12p40 42%, and IL-12p35/p40 27%; p<0.01). Tretinoin 45-58 interleukin 12b Mus musculus 180-188 20826012-4 2010 Treatment with the transcriptional activator retinoic acid (RA) suppressed mRNA expression and protein release of several important cytokines (IL-1beta 4%, IL-6 21%, TNFalpha 30%, IL-12p40 42%, and IL-12p35/p40 27%; p<0.01). Tretinoin 45-58 interleukin 12b Mus musculus 185-188 20826012-4 2010 Treatment with the transcriptional activator retinoic acid (RA) suppressed mRNA expression and protein release of several important cytokines (IL-1beta 4%, IL-6 21%, TNFalpha 30%, IL-12p40 42%, and IL-12p35/p40 27%; p<0.01). Tretinoin 60-62 interleukin 12b Mus musculus 180-188 20826012-4 2010 Treatment with the transcriptional activator retinoic acid (RA) suppressed mRNA expression and protein release of several important cytokines (IL-1beta 4%, IL-6 21%, TNFalpha 30%, IL-12p40 42%, and IL-12p35/p40 27%; p<0.01). Tretinoin 60-62 interleukin 12b Mus musculus 185-188 20601178-0 2010 Licochalcone E reduces chronic allergic contact dermatitis and inhibits IL-12p40 production through down-regulation of NF-kappa B. licochalcone 0-12 interleukin 12b Mus musculus 72-80 20621581-8 2010 Quantitative RT-PCR showed that epinephrine pre-treatment induced a significant transcriptional decrease of IL-12p40 and a significant increase of IL-12p35 and IL-23p19. Epinephrine 32-43 interleukin 12b Mus musculus 108-116 21141074-3 2010 STA-5326 is a low molecular weight compound developed through highthroughput IL-12/ IL-23 p40 inhibitor screening. apilimod 0-8 interleukin 12b Mus musculus 90-93 20601178-4 2010 Licochalcone E dose-dependently inhibited IL-12p40 production from lipopolysaccharide-stimulated RAW264.7 macrophage cells. licochalcone 0-12 interleukin 12b Mus musculus 42-50 20601178-7 2010 Using a chronic allergic contact dermatitis model induced by repeated application of oxazolone, we showed that licochalcone E inhibited the increased IL-12p40 expression and ear thickness induced by oxazolone. Oxazolone 85-94 interleukin 12b Mus musculus 150-158 20601178-7 2010 Using a chronic allergic contact dermatitis model induced by repeated application of oxazolone, we showed that licochalcone E inhibited the increased IL-12p40 expression and ear thickness induced by oxazolone. licochalcone 111-123 interleukin 12b Mus musculus 150-158 20601178-7 2010 Using a chronic allergic contact dermatitis model induced by repeated application of oxazolone, we showed that licochalcone E inhibited the increased IL-12p40 expression and ear thickness induced by oxazolone. Oxazolone 199-208 interleukin 12b Mus musculus 150-158 20601178-8 2010 Taken together, licochalcone E inhibits IL-12p40 production and has therapeutic potential to reduce skin inflammation. licochalcone 16-28 interleukin 12b Mus musculus 40-48 20145200-6 2010 SHP-1 regulation of IL-12p40 transcription requires both its catalytic activity and phosphotyrosine binding by its N-terminal SH2 domain and is mediated via repression of, and interaction with, phosphatidylinositol 3-kinase, without affecting c-Rel activation. Phosphotyrosine 84-99 interleukin 12b Mus musculus 20-28 20200406-3 2010 We report here that several broad-spectrum HDAC inhibitors, including TSA and SAHA, suppressed the LPS-induced mRNA expression of the proinflammatory mediators Edn-1, Ccl-7/MCP-3, and Il-12p40 but amplified the expression of the proatherogenic factors Cox-2 and Pai-1/serpine1 in primary mouse BMM. Vorinostat 78-82 interleukin 12b Mus musculus 184-192 20200406-3 2010 We report here that several broad-spectrum HDAC inhibitors, including TSA and SAHA, suppressed the LPS-induced mRNA expression of the proinflammatory mediators Edn-1, Ccl-7/MCP-3, and Il-12p40 but amplified the expression of the proatherogenic factors Cox-2 and Pai-1/serpine1 in primary mouse BMM. trichostatin A 70-73 interleukin 12b Mus musculus 184-192 20141737-7 2010 DCs in the low-, medium- and high-dose astilbin groups exhibited weaker capabilities for antigen phagocytosis and less contents of IL-12p40 in the supernatants than in the LPS group. astilbin 39-47 interleukin 12b Mus musculus 131-139 20723405-14 2010 (3) IL-12p40, IL-12p70 secretion by DC from sirolimus devoid trauma group [(120 +/- 13), (10 +/- 3) pg/mL] were significantly reduced as compared with those from sirolimus devoid control group [(200 +/- 25), (20 +/- 6) pg/mL, with F value respectively 218.646, 310.253, P values all below 0.05]. Sirolimus 44-53 interleukin 12b Mus musculus 4-12 20093200-7 2010 Moreover, anandamide prior to sensitization increased both the expression of DC co-stimulatory molecules (CD80/CD86) and IL-12/IL23 (p40) production ex vivo. anandamide 10-20 interleukin 12b Mus musculus 133-136 20370487-7 2010 Intranasal losartan not only decreased IL-12p40/p70, IL-1beta, and GM-CSF, but also increased IL-10, which suppresses inflammation. Losartan 11-19 interleukin 12b Mus musculus 39-47 20673883-2 2010 Treatment of BMDCs with Polyporus polysaccharide (PPS) resulted in enhanced cell-surface expression of CD86, as well as enhanced production of both interleukin (IL)-12 p40 and IL-10 in a dose-dependent manner. pps 50-53 interleukin 12b Mus musculus 168-171 20673883-4 2010 PPS-induced production of IL-12 p40 was inhibited by monoclonal antibodies to Toll-like receptor 4 (TLR4). pps 0-3 interleukin 12b Mus musculus 32-35 19839588-5 2009 The mRNA expression of IL-12p40, IL-2 and IFN-gamma were increased significantly in MZF-treated spleen. mzf 84-87 interleukin 12b Mus musculus 23-31 20046053-8 2010 Pretreatment with clarithromycin ex vivo decreased CD40 expression on DCs obtained from P. aeruginosa-infected mice and also decreased the production of IL-6, IL-12p40 and TNF-alpha by DCs. Clarithromycin 18-32 interleukin 12b Mus musculus 159-167 19759192-3 2009 Using this two-stage chemical carcinogenesis protocol, we found that the development of DMBA/TPA-induced skin tumors was diminished in IL-12p40-knockout mice than in their wild-type counterparts. 9,10-Dimethyl-1,2-benzanthracene 88-92 interleukin 12b Mus musculus 135-143 19759192-3 2009 Using this two-stage chemical carcinogenesis protocol, we found that the development of DMBA/TPA-induced skin tumors was diminished in IL-12p40-knockout mice than in their wild-type counterparts. Tetradecanoylphorbol Acetate 93-96 interleukin 12b Mus musculus 135-143 19893639-13 2009 In conclusion, AZM reduced IL-12p40 transcriptional activity by inhibiting the binding of AP-1, NFAT, and ICSBP to the promoter site. Azithromycin 15-18 interleukin 12b Mus musculus 27-35 19760679-5 2009 Conversely, accumulation of beta-carotene was negatively correlated with the transcription of immune-active molecules, such as IL-1beta, IL-6, and IL-12 p40, in cells stimulated by LPS and INF-gamma. beta Carotene 28-41 interleukin 12b Mus musculus 147-156 19577625-6 2009 RESULTS: We found that SR significantly inhibited the production of NO, interleukin (IL)-3, IL-6, IL-10, IL-12p40, IL-17, interferon-inducible protein (IP)-10, keratinocyte-derived chemokine (KC), and vascular endothelial growth factor (VEGF) in LPS-induced RAW 264.7 cells at the concentrations of 25, 50, 100, 200 microg/ml (p<0.05). Strontium 23-25 interleukin 12b Mus musculus 105-113 19893639-4 2009 We investigated the effect of azithromycin on IL-12p40 production in macrophages after lipopolysaccharide (LPS)/interferon (IFN)-gamma stimulation. Azithromycin 30-42 interleukin 12b Mus musculus 46-54 19893639-9 2009 AZM reduced the induction of IL-12p40 by LPS/IFN-gamma in a dose dependent manner. Azithromycin 0-3 interleukin 12b Mus musculus 29-37 19893639-10 2009 AZM inhibited the binding of AP-1, nuclear factor of activated T cells (NFAT), and ICSBP, to the DNA binding site in the IL-12p40 promoter. Azithromycin 0-3 interleukin 12b Mus musculus 121-129 19893639-11 2009 AZM also reduced LPS/IFN-gamma-induced IL-12p40 promoter activity. Azithromycin 0-3 interleukin 12b Mus musculus 39-47 19733186-9 2009 KEY FINDINGS: Pre-treatment with C-K significantly inhibited zymosan-mediated secretion of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-12 p40, and the activation of ERK1/2 and p38. ginsenoside M1 33-36 interleukin 12b Mus musculus 150-153 19454652-10 2009 In LPS-activated murine macrophages, ethyl pyruvate decreased expression of IL-12 p40 and NO production but did not affect IL-10 levels. ethyl pyruvate 37-51 interleukin 12b Mus musculus 76-85 19724678-2 2009 Here, we report that long-term exposure to ultraviolet (UV) radiation resulted in enhancement of the levels of cell survival kinases, such as phosphatidylinositol 3-kinase (PI3K), Akt (Ser(473)), p-ERK1/2, and p-p38 in the skin of IL-12p40 knockout (IL-12 KO) mice compared with the skin of wild-type mice. Serine 185-188 interleukin 12b Mus musculus 231-239 19487420-6 2009 Moreover, CT and dbcAMP inhibited the binding of IRF8 to the IFN-stimulated response element (ISRE)-like element in the mouse IL-12p40 promoter, likely by blocking the formation of ISRE-binding IRF1-IRF8 heterocomplexes. Bucladesine 17-23 interleukin 12b Mus musculus 126-134 19587012-0 2009 Suppression of regulatory T cells by IL-12p40 homodimer via nitric oxide. Nitric Oxide 60-72 interleukin 12b Mus musculus 37-45 19235606-5 2009 Pre-incubation with p-cresol inhibited IL-12 p40 production of LcS-stimulated J774.1 cells, a murine macrophage-like cell line, in a dose-dependent manner. 4-cresol 20-28 interleukin 12b Mus musculus 39-48 19235606-5 2009 Pre-incubation with p-cresol inhibited IL-12 p40 production of LcS-stimulated J774.1 cells, a murine macrophage-like cell line, in a dose-dependent manner. lcs 63-66 interleukin 12b Mus musculus 39-48 19235606-6 2009 IL-12 p40 and p70 production of LcS-stimulated murine peritoneal macrophages was also inhibited by p-cresol. lcs 32-35 interleukin 12b Mus musculus 0-9 19235606-6 2009 IL-12 p40 and p70 production of LcS-stimulated murine peritoneal macrophages was also inhibited by p-cresol. 4-cresol 99-107 interleukin 12b Mus musculus 0-9 19020550-2 2009 Using IL-12p40 knockout (KO) mice and their wild-type counterparts and an established photocarcinogenesis protocol, we found that although administration of GTPs (0.2%, w/v) in drinking water significantly reduced UVB-induced tumor development in wild-type mice, this treatment had a nonsignificant effect in IL-12-KO mice. gtps 157-161 interleukin 12b Mus musculus 6-14 18922202-6 2009 Venlafaxine suppressed the generation of pro-inflammatory cytokines IL-12 p40, TNF-alpha and IFN-gamma in encephalitogenic T-cell clones, splenocytes and peritoneal macrophages in vitro. Venlafaxine Hydrochloride 0-11 interleukin 12b Mus musculus 68-77 19020550-3 2009 GTPs resulted in reduction in the levels of markers of inflammation (cyclooxygenase-2, prostaglandin E(2), proliferating cell nuclear antigen, and cyclin D1) and proinflammatory cytokines (tumor necrosis factor-alpha, IL-6, and IL-1beta) in chronically UVB-exposed skin and skin tumors of wild-type mice but less effective in IL-12p40-KO mice. gtps 0-4 interleukin 12b Mus musculus 326-334 19428830-3 2009 In vitro, the adjuvant combination of CpG ODN, indolicidin and polyphosphazene (CpG/indol/PP) enhanced the secretion of TNF-alpha, IL-12p40, and IL-6 by bone marrow-derived DCs (BMDCs) when compared to the individual components. poly(phosphazene) 63-78 interleukin 12b Mus musculus 131-139 19185589-0 2009 Modulation of TNFalpha, IL-10 and IL-12p40 levels by a ceramide-1-phosphate analog, PCERA-1, in vivo and ex vivo in primary macrophages. ceramide 1-phosphate 55-75 interleukin 12b Mus musculus 34-42 19428830-3 2009 In vitro, the adjuvant combination of CpG ODN, indolicidin and polyphosphazene (CpG/indol/PP) enhanced the secretion of TNF-alpha, IL-12p40, and IL-6 by bone marrow-derived DCs (BMDCs) when compared to the individual components. indole 47-52 interleukin 12b Mus musculus 131-139 18509360-5 2008 UVB irradiation alone did not upregulate IL-10 mRNA, but UV+DNFB upregulated IL-10 mRNA as early as 3-6 hours after DNFB application, immediately preceding a decrease of IL-12p40 mRNA from the level induced by UVB. Dinitrofluorobenzene 60-64 interleukin 12b Mus musculus 170-178 19032358-10 2009 The hydroxyproline content of the lung and peribronchial fibrosis were, however, significantly increased in IL-12p40(-/-) mice. Hydroxyproline 4-18 interleukin 12b Mus musculus 108-116 19234608-8 2009 Moreover, LPS-induced IL-12p40 gene expression was dose-dependently inhibited in TLE-treated splenocytes. (5r)-3-Ethyl-4-Hydroxy-5-Methyl-5-[(1e)-2-Methylbuta-1,3-Dien-1-Yl]thiophen-2(5h)-One 81-84 interleukin 12b Mus musculus 22-30 18817984-2 2008 It was found that acute MPTP treatment induced behavioral dysfunction, activated microglia/astrocytes, and increased the levels of IL-10, IL-12(p40) IL-13, IFN-gamma, and MCP-1 in CSF in B6, but not in BALB. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 24-28 interleukin 12b Mus musculus 144-147 18509360-2 2008 Analysis of cytokine expression in murine draining lymph nodes (DLNs) revealed that IL-12p40 mRNA and protein expression as well as IL-12p70 protein were upregulated after application of the contact sensitizer 2,4 dinitro-1-fluorobenzene (DNFB) to normal skin. Dinitrofluorobenzene 210-237 interleukin 12b Mus musculus 84-92 18598692-7 2008 Both pirfenidone and prednisolone suppressed the increase in lung interleukin (IL)-1beta, IL-6, IL-12p40 and monocyte chemoattractant protein (MCP)-1 levels induced by bleomycin. pirfenidone 5-16 interleukin 12b Mus musculus 96-104 18509360-2 2008 Analysis of cytokine expression in murine draining lymph nodes (DLNs) revealed that IL-12p40 mRNA and protein expression as well as IL-12p70 protein were upregulated after application of the contact sensitizer 2,4 dinitro-1-fluorobenzene (DNFB) to normal skin. Dinitrofluorobenzene 239-243 interleukin 12b Mus musculus 84-92 18509360-4 2008 By contrast, following DNFB application to UV-irradiated skin (UV+DNFB), IL-12p40 mRNA was not upregulated, and DLN IL-12p40 and p70 proteins were reduced. Dinitrofluorobenzene 23-27 interleukin 12b Mus musculus 73-81 18509360-4 2008 By contrast, following DNFB application to UV-irradiated skin (UV+DNFB), IL-12p40 mRNA was not upregulated, and DLN IL-12p40 and p70 proteins were reduced. Dinitrofluorobenzene 23-27 interleukin 12b Mus musculus 116-124 18602062-10 2008 The mRNA expression of MIF, TNF-alpha, IFN-gamma, IL-2 and IL-12 p40, but not of IL-4, IL-5 and IL-13 in the lesions was significantly reduced by EGCG (p<0.05). epigallocatechin gallate 146-150 interleukin 12b Mus musculus 59-68 18717637-7 2008 Concentrations of interleukin (IL)-12 p40, RANTES, macrophage chemotactic protein-1, and cytokine-induced neutrophil chemoattractant were significantly lower in mice treated with clarithromycin alone and/or combination therapy compared with dexamethasone alone and/or placebo; combination therapy resulted in a significantly greater reduction than clarithromycin alone for IL-12 p40 and RANTES. Clarithromycin 179-193 interleukin 12b Mus musculus 373-382 18598692-7 2008 Both pirfenidone and prednisolone suppressed the increase in lung interleukin (IL)-1beta, IL-6, IL-12p40 and monocyte chemoattractant protein (MCP)-1 levels induced by bleomycin. Prednisolone 21-33 interleukin 12b Mus musculus 96-104 18598692-7 2008 Both pirfenidone and prednisolone suppressed the increase in lung interleukin (IL)-1beta, IL-6, IL-12p40 and monocyte chemoattractant protein (MCP)-1 levels induced by bleomycin. Bleomycin 168-177 interleukin 12b Mus musculus 96-104 18593333-5 2008 Functional IL-12 is a heterodimer consisting of two disulfide-linked subunits, p35 and p40. Disulfides 52-61 interleukin 12b Mus musculus 87-90 18504053-7 2008 Dexamethasone prevented LPS-induced production of cytokines/chemokines such as interleukin (IL)-5, IL-1alpha, TNFalpha, IL-12(p40), and RANTES in PCLS. Dexamethasone 0-13 interleukin 12b Mus musculus 126-129 18535659-3 2008 This approach led to the identification of the mmaA4 gene, which encodes a methyl transferase required for introducing the distal oxygen-containing modifications of mycolic acids, as a key locus involved in the repression of IL-12p40. Oxygen 130-136 interleukin 12b Mus musculus 225-233 18535659-3 2008 This approach led to the identification of the mmaA4 gene, which encodes a methyl transferase required for introducing the distal oxygen-containing modifications of mycolic acids, as a key locus involved in the repression of IL-12p40. Mycolic Acids 165-178 interleukin 12b Mus musculus 225-233 18535659-6 2008 Treatment of macrophages with trehalose dimycolate (TDM) purified from the DeltammaA4 mutant stimulated increased IL-12p40, similar to the increase observed from DeltammaA4 mutant-infected macrophages. Cord Factors 30-50 interleukin 12b Mus musculus 114-122 18442787-5 2008 Cyclosporine A and anti-IL-12p40 (in the acute phase) and anti-CD3 (in the chronic phase) treatment attenuated local cytokine levels, improved clinical symptoms (CsA and anti-IL-12p40) and histology (CsA and anti-CD3). Cyclosporine 0-14 interleukin 12b Mus musculus 175-183 18442787-5 2008 Cyclosporine A and anti-IL-12p40 (in the acute phase) and anti-CD3 (in the chronic phase) treatment attenuated local cytokine levels, improved clinical symptoms (CsA and anti-IL-12p40) and histology (CsA and anti-CD3). Cyclosporine 162-165 interleukin 12b Mus musculus 24-32 17981792-7 2008 IL-12p40 was also produced by poly(A:U)-stimulated pDC in a TLR7-dependent manner. Poly A 30-36 interleukin 12b Mus musculus 0-8 18389479-3 2008 First, we observed that, as compared with two other cationic liposomes, only diC14-amidine liposomes induced the production of IL-12p40 and TNF-alpha by mouse bone marrow-derived DC. N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine 77-90 interleukin 12b Mus musculus 127-135 18389479-4 2008 DiC14-amidine liposomes also activated human DC, as shown by synthesis of IL-12p40 and TNF-alpha, accumulation of IL-6, IFN-beta and CXCL10 mRNA, and up-regulation of membrane expression of CD80 and CD86. N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine 0-13 interleukin 12b Mus musculus 74-82 18083110-4 2008 Treatment with methyl-prednisolone or anti-TNF antibody attenuated the systemic (TNF, IL-6, IL-12p40, and CXCL1) and local (colonic TNF and iNOS mRNA expression) response induced by R-848. Methylprednisolone 15-34 interleukin 12b Mus musculus 92-100 17981792-8 2008 In addition to pDC, conventional dendritic cell (cDC) also produced IL-12p40 in response to poly(A:U). Poly A 92-96 interleukin 12b Mus musculus 68-76 18322216-4 2008 IL-12p40 production and CD40 expression were attenuated by chloroquine, bafilomycin A, and inhibitory oligodeoxynucleotides (ODN) that suppressed the responses caused by CpG-ODN. Chloroquine 59-70 interleukin 12b Mus musculus 0-8 18322216-4 2008 IL-12p40 production and CD40 expression were attenuated by chloroquine, bafilomycin A, and inhibitory oligodeoxynucleotides (ODN) that suppressed the responses caused by CpG-ODN. bafilomycin A 72-85 interleukin 12b Mus musculus 0-8 18322216-4 2008 IL-12p40 production and CD40 expression were attenuated by chloroquine, bafilomycin A, and inhibitory oligodeoxynucleotides (ODN) that suppressed the responses caused by CpG-ODN. Oligodeoxyribonucleotides 102-123 interleukin 12b Mus musculus 0-8 18322216-4 2008 IL-12p40 production and CD40 expression were attenuated by chloroquine, bafilomycin A, and inhibitory oligodeoxynucleotides (ODN) that suppressed the responses caused by CpG-ODN. Oligodeoxyribonucleotides 125-128 interleukin 12b Mus musculus 0-8 18322216-4 2008 IL-12p40 production and CD40 expression were attenuated by chloroquine, bafilomycin A, and inhibitory oligodeoxynucleotides (ODN) that suppressed the responses caused by CpG-ODN. CPG-oligonucleotide 170-177 interleukin 12b Mus musculus 0-8 17981792-7 2008 IL-12p40 was also produced by poly(A:U)-stimulated pDC in a TLR7-dependent manner. Uranium 37-39 interleukin 12b Mus musculus 0-8 17196234-7 2007 Analysis of the ability of ex vivo-cultured splenocytes to secrete cytokines demonstrated a marked reduction in IFN-gamma and IL-12p40 production associated with Pb exposure. Lead 162-164 interleukin 12b Mus musculus 126-134 17785780-3 2007 Treatment of SpDC with laminarin or glucan phosphate, two molecules known to block Dectin-1-dependent activity, led to a reduction in M. tuberculosis-induced IL-12p40 as well as IL-12p70 production. laminaran 23-32 interleukin 12b Mus musculus 158-166 17785780-3 2007 Treatment of SpDC with laminarin or glucan phosphate, two molecules known to block Dectin-1-dependent activity, led to a reduction in M. tuberculosis-induced IL-12p40 as well as IL-12p70 production. glucan phosphate 36-52 interleukin 12b Mus musculus 158-166 17785780-4 2007 Moreover, SpDC from Dectin-1-/- chimeric mice displayed reduced IL-12p40 production in response to mycobacteria when compared with Dectin-sufficient DC. dectin 20-26 interleukin 12b Mus musculus 64-72 17635610-3 2007 We report here the surprising observation that treatment of murine dendritic cells with the HDAC inhibitors trichostatin A (TSA) or suberoylanilide hydroxamic acid (SAHA) in non-apoptotic concentrations strongly inhibited induction of both interleukin-12 protein p40 (IL-12p40) mRNA and protein upon stimulation of Toll-like receptors (TLRs). trichostatin A 108-122 interleukin 12b Mus musculus 263-266 17635610-3 2007 We report here the surprising observation that treatment of murine dendritic cells with the HDAC inhibitors trichostatin A (TSA) or suberoylanilide hydroxamic acid (SAHA) in non-apoptotic concentrations strongly inhibited induction of both interleukin-12 protein p40 (IL-12p40) mRNA and protein upon stimulation of Toll-like receptors (TLRs). trichostatin A 108-122 interleukin 12b Mus musculus 268-276 17635610-3 2007 We report here the surprising observation that treatment of murine dendritic cells with the HDAC inhibitors trichostatin A (TSA) or suberoylanilide hydroxamic acid (SAHA) in non-apoptotic concentrations strongly inhibited induction of both interleukin-12 protein p40 (IL-12p40) mRNA and protein upon stimulation of Toll-like receptors (TLRs). trichostatin A 124-127 interleukin 12b Mus musculus 263-266 17635610-3 2007 We report here the surprising observation that treatment of murine dendritic cells with the HDAC inhibitors trichostatin A (TSA) or suberoylanilide hydroxamic acid (SAHA) in non-apoptotic concentrations strongly inhibited induction of both interleukin-12 protein p40 (IL-12p40) mRNA and protein upon stimulation of Toll-like receptors (TLRs). trichostatin A 124-127 interleukin 12b Mus musculus 268-276 17635610-3 2007 We report here the surprising observation that treatment of murine dendritic cells with the HDAC inhibitors trichostatin A (TSA) or suberoylanilide hydroxamic acid (SAHA) in non-apoptotic concentrations strongly inhibited induction of both interleukin-12 protein p40 (IL-12p40) mRNA and protein upon stimulation of Toll-like receptors (TLRs). Vorinostat 132-163 interleukin 12b Mus musculus 263-266 17635610-3 2007 We report here the surprising observation that treatment of murine dendritic cells with the HDAC inhibitors trichostatin A (TSA) or suberoylanilide hydroxamic acid (SAHA) in non-apoptotic concentrations strongly inhibited induction of both interleukin-12 protein p40 (IL-12p40) mRNA and protein upon stimulation of Toll-like receptors (TLRs). Vorinostat 132-163 interleukin 12b Mus musculus 268-276 17635610-3 2007 We report here the surprising observation that treatment of murine dendritic cells with the HDAC inhibitors trichostatin A (TSA) or suberoylanilide hydroxamic acid (SAHA) in non-apoptotic concentrations strongly inhibited induction of both interleukin-12 protein p40 (IL-12p40) mRNA and protein upon stimulation of Toll-like receptors (TLRs). Vorinostat 165-169 interleukin 12b Mus musculus 263-266 17635610-3 2007 We report here the surprising observation that treatment of murine dendritic cells with the HDAC inhibitors trichostatin A (TSA) or suberoylanilide hydroxamic acid (SAHA) in non-apoptotic concentrations strongly inhibited induction of both interleukin-12 protein p40 (IL-12p40) mRNA and protein upon stimulation of Toll-like receptors (TLRs). Vorinostat 165-169 interleukin 12b Mus musculus 268-276 17517874-10 2007 Farnesol inhibited production of both IL-12 p40 and p70 from IFN-gamma/LPS-stimulated macrophages. Farnesol 0-8 interleukin 12b Mus musculus 38-47 17363777-8 2007 Greater elevations in levels of TGF-beta and IL-12p40 were produced in the lungs and AMs from bleomycin-challenged HPS mice than in WT mice. Bleomycin 94-103 interleukin 12b Mus musculus 45-53 17347151-0 2007 Cyclosporin A and FK506 inhibit IL-12p40 production through the calmodulin/calmodulin-dependent protein kinase-activated phosphoinositide 3-kinase in lipopolysaccharide-stimulated human monocytic cells. Cyclosporine 0-13 interleukin 12b Mus musculus 32-40 17347151-0 2007 Cyclosporin A and FK506 inhibit IL-12p40 production through the calmodulin/calmodulin-dependent protein kinase-activated phosphoinositide 3-kinase in lipopolysaccharide-stimulated human monocytic cells. Tacrolimus 18-23 interleukin 12b Mus musculus 32-40 17347151-2 2007 However, the mechanisms underlying the inhibitory effects of CyA and FK506 on the production of IL-12p40, a critical component of IL-12, remain unknown. Tacrolimus 69-74 interleukin 12b Mus musculus 96-104 17347151-5 2007 Contrary to these observations, we show that LPS-induced IL-12p40 production in human monocytic cells is positively regulated by the calcium pathway and in particular by calmodulin-(CaM) and CaM-dependent protein kinase-II (CaMK-II)-activated PI3K. Calcium 133-140 interleukin 12b Mus musculus 57-65 17347151-9 2007 Importantly, both CyA and FK506 down-regulated LPS-induced IL-12p40 transcription by inhibiting CaM/CaMK-II-activated PI3K and their downstream transcription factors NFkappaB and AP-1 independent of the JNK pathway. Tacrolimus 26-31 interleukin 12b Mus musculus 59-67 17312143-6 2007 In vivo, gamma-PGA NPs were preferentially internalized by APCs (DCs and macrophages) and induced the production of IL-12p40 and IL-6. poly(gamma-glutamic acid) 9-18 interleukin 12b Mus musculus 116-124 17202329-10 2007 Administration of chloroquine to virus-infected BBDR rats decreases the incidence of diabetes and decreases blood levels of IL-12p40. Chloroquine 18-29 interleukin 12b Mus musculus 124-132 17056578-3 2006 Administration of anti-IL-12p35 or anti-IL-12p40 mAb to previously OVA-sensitized BALB/c mice concomitantly with exposure to nebulized OVA, abolished both the development of bronchial hyperresponsiveness to metacholine as well as the eosinophilia in bronchoalveolar lavage fluid and peripheral blood. metacholine 207-218 interleukin 12b Mus musculus 40-48 16960387-5 2006 Lipopolysaccharide-stimulated transcriptions of IL-1beta and IL-12 p40 in RAW264 were inhibited by beta-carotene but not by alpha-tocopherol. beta Carotene 99-112 interleukin 12b Mus musculus 67-70 16845523-6 2006 In okLTA-treated skin, IL-12p40/p-STAT4 positive cellular infiltration was extensive while IL-4/p-STAT6 positive cell infiltration was seen to diminish considerably, compared to untreated NC mice. oklta 3-8 interleukin 12b Mus musculus 23-31 16893987-6 2006 Activation of GA-12 (a repressor element of IL-12 p40), rather than suppression of promoter elements, such as binding sites for NF-kappaB, AP-1, and IRF-1, was detected in LPS-stimulated RAW264.7 cells, accompanying hyperactivation of extracellular signal-related kinase (ERK). gibberellin A12 14-19 interleukin 12b Mus musculus 44-53 16867260-1 2006 AIM: To investigate whether IL-12p40 plays a crucial role in regulating islet allograft rejection in a streptozotocin (STZ)-induced diabetes mouse model. Streptozocin 103-117 interleukin 12b Mus musculus 28-36 16867260-1 2006 AIM: To investigate whether IL-12p40 plays a crucial role in regulating islet allograft rejection in a streptozotocin (STZ)-induced diabetes mouse model. Streptozocin 119-122 interleukin 12b Mus musculus 28-36 16893987-7 2006 When ERK activation was suppressed by an inhibitor (U0126), production of p40 rose from an undetectable to a substantial level and GA-12 activation decreased. U 0126 52-57 interleukin 12b Mus musculus 74-77 16893987-9 2006 Pretreatment of the cells with phorbol myristate acetate to enhance ERK activation reduced p40 production in response to the optimal LPS stimulation. Tetradecanoylphorbol Acetate 31-56 interleukin 12b Mus musculus 91-94 16893987-10 2006 Taken together, these results demonstrate that hyperactivation of the ERK pathway plays a role in upstream signaling for the activation of GA-12, leading to the repression of IL-12 p40 production in mouse macrophages. gibberellin A12 139-144 interleukin 12b Mus musculus 175-184 16504533-8 2006 Reduced lipopolysaccharide-triggered cytokine production (of IL-12p40, IFN-gamma, IL-6 and TNF-alpha) by draining lymph node cells of mice sensitized and challenged with DPCP indicated that no adaptation is induced. diphenylcyclopropenone 170-174 interleukin 12b Mus musculus 61-69 16249388-8 2006 The CaM inhibitor trifIuoperazine increased both nuclear c-rel and IL-12 p40 levels in H2O2-treated macrophages, emphasizing a role of CaM in these processes. trifiuoperazine 18-33 interleukin 12b Mus musculus 67-76 16540644-7 2006 Additionally, a higher load of UV-induced pyrimidine dimers could be detected in the skin of UV-exposed IL-12p40-/- mice. pyrimidine 42-52 interleukin 12b Mus musculus 104-112 16249388-0 2006 Hydrogen peroxide inhibits IL-12 p40 induction in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein. Hydrogen Peroxide 0-17 interleukin 12b Mus musculus 27-36 16519736-5 2006 Furthermore, the different sensitivities of Th1 cells to PGE and db-cAMP were dependent on the different levels of IL-12 p40 monomers or homodimers in the spleen cell cultures. Prostaglandins E 57-60 interleukin 12b Mus musculus 115-124 16519736-5 2006 Furthermore, the different sensitivities of Th1 cells to PGE and db-cAMP were dependent on the different levels of IL-12 p40 monomers or homodimers in the spleen cell cultures. Bucladesine 65-72 interleukin 12b Mus musculus 115-124 16519736-6 2006 As the endogenous specific inhibitors of IL-12 p70 (heterodimers of p40 and p35), large amounts of IL-12 p40 monomers or homodimers in the spleen cell cultures of C57BL and DBA/1 mice enhanced the ability of PGE1 and db-cAMP to inhibit IFN-gamma production by antagonizing the activity of IL-12 heterodimers. Alprostadil 208-212 interleukin 12b Mus musculus 99-108 16519736-6 2006 As the endogenous specific inhibitors of IL-12 p70 (heterodimers of p40 and p35), large amounts of IL-12 p40 monomers or homodimers in the spleen cell cultures of C57BL and DBA/1 mice enhanced the ability of PGE1 and db-cAMP to inhibit IFN-gamma production by antagonizing the activity of IL-12 heterodimers. Bucladesine 217-224 interleukin 12b Mus musculus 99-108 16443217-0 2006 Role of cannabinoid receptors in Delta-9-tetrahydrocannabinol suppression of IL-12p40 in mouse bone marrow-derived dendritic cells infected with Legionella pneumophila. Dronabinol 33-61 interleukin 12b Mus musculus 77-85 16249388-2 2006 We now provide evidence that hydrogen peroxide (H2O2), a major component of ROSs, inhibits interleukin-12 (IL-12) p40 and IL-12 p70 induction in murine macrophages and catalase pretreatment prevents H2O2-mediated down-regulation of IL-12. Hydrogen Peroxide 29-46 interleukin 12b Mus musculus 114-117 16249388-2 2006 We now provide evidence that hydrogen peroxide (H2O2), a major component of ROSs, inhibits interleukin-12 (IL-12) p40 and IL-12 p70 induction in murine macrophages and catalase pretreatment prevents H2O2-mediated down-regulation of IL-12. Hydrogen Peroxide 48-52 interleukin 12b Mus musculus 114-117 16249388-8 2006 The CaM inhibitor trifIuoperazine increased both nuclear c-rel and IL-12 p40 levels in H2O2-treated macrophages, emphasizing a role of CaM in these processes. Hydrogen Peroxide 87-91 interleukin 12b Mus musculus 67-76 16249388-3 2006 Endogenous accumulation of H2O2/ROSs in macrophages treated with alloxan resulted in IL-12 p40 inhibition. Hydrogen Peroxide 27-31 interleukin 12b Mus musculus 85-94 16462022-3 2006 Andrographolide decreased TNF-alpha, IL-12a and IL-12b at mRNA level, and reduced the production of TNF-alpha and IL-12p70 proteins in a concentration-dependent manner. andrographolide 0-15 interleukin 12b Mus musculus 48-54 16249388-3 2006 Endogenous accumulation of H2O2/ROSs in macrophages treated with alloxan resulted in IL-12 p40 inhibition. Reactive Oxygen Species 32-36 interleukin 12b Mus musculus 85-94 16249388-5 2006 Overexpression of c-rel restored IL-12 p40 on stimulation with lipopolysaccharide plus IFN-gamma during H2O2 treatment. Hydrogen Peroxide 104-108 interleukin 12b Mus musculus 33-42 16495657-4 2006 The actinase E- and Benzonase-treated or untreated cell wall fraction of Nz8 enhanced both IFN-gamma and IL-12 p40 expression, while the cell plasma fraction had little effect. CHEMBL4792974 73-76 interleukin 12b Mus musculus 111-114 16476011-0 2006 Hydrogen peroxide increases interleukin-12 p40/p70 molecular ratio and induces Th2-predominant responses in mice. Hydrogen Peroxide 0-17 interleukin 12b Mus musculus 43-46 16330529-5 2006 Similarly, activation of PKC with phorbol 12-myristate 13-acetate (PMA) depressed LPS-stimulated IL-12p40 secretion, and depletion of PKC augmented LPS-stimulated IL-12p40 secretion. Tetradecanoylphorbol Acetate 34-65 interleukin 12b Mus musculus 97-105 16330529-5 2006 Similarly, activation of PKC with phorbol 12-myristate 13-acetate (PMA) depressed LPS-stimulated IL-12p40 secretion, and depletion of PKC augmented LPS-stimulated IL-12p40 secretion. Tetradecanoylphorbol Acetate 67-70 interleukin 12b Mus musculus 97-105 16467332-6 2006 Expression of NOD2, IFN-beta, and IL-12p40 was higher with LF administration than with water or BSA administration. Water 87-92 interleukin 12b Mus musculus 34-42 16303184-4 2006 The studies demonstrated that 9-cis-RA inhibited the production of nitric oxide (NO) as well as the pro-inflammatory cytokines TNF-alpha, IL-1beta and IL-12 p40 by LPS-stimulated microglia. Alitretinoin 30-38 interleukin 12b Mus musculus 157-160 16476011-7 2006 Together, these results suggest that H(2)O(2)-induced overproduction of IL-12p40 promotes the Th2-predominant response through increased production of IL-12p40-homodimers, which could serve as an antagonist of the Th1-inducing cytokine IL-12p70. Hydrogen Peroxide 37-45 interleukin 12b Mus musculus 72-80 16476011-7 2006 Together, these results suggest that H(2)O(2)-induced overproduction of IL-12p40 promotes the Th2-predominant response through increased production of IL-12p40-homodimers, which could serve as an antagonist of the Th1-inducing cytokine IL-12p70. Hydrogen Peroxide 37-45 interleukin 12b Mus musculus 151-159 16396683-10 2006 IL-12 p35 mRNA was not increased in either strain after silica exposure; IL-12 p40 mRNA was up-regulated after silica in WT mice and constitutively absent in the IL-12 KO mice. Silicon Dioxide 111-117 interleukin 12b Mus musculus 73-82