PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 30660030-2 2019 The use of co-monomers, such as 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP), is thought to be crucial for hybridization owing to their ionic-binding to calcium and co-polymerization in the polymerizable adhesives. methacryloyloxydecyl dihydrogen phosphate 32-76 dipeptidase 1 Homo sapiens 81-84 30660030-2 2019 The use of co-monomers, such as 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP), is thought to be crucial for hybridization owing to their ionic-binding to calcium and co-polymerization in the polymerizable adhesives. Calcium 162-169 dipeptidase 1 Homo sapiens 81-84 30660030-8 2019 Such reduced mechanical integrity of hybridization could also be associated with the inhibition of nano-layering between 10-MDP and mineralized tissue in the presence of hydroxyethyl methacrylate (HEMA). hydroxyethyl methacrylate 170-195 dipeptidase 1 Homo sapiens 124-127 30660030-8 2019 Such reduced mechanical integrity of hybridization could also be associated with the inhibition of nano-layering between 10-MDP and mineralized tissue in the presence of hydroxyethyl methacrylate (HEMA). hydroxyethyl methacrylate 197-201 dipeptidase 1 Homo sapiens 124-127 30406140-1 2018 Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) is an effective anti-inflammatory drug in treating rheumatoid arthritis (RA) for over 15 years in China. Technetium-99 0-13 dipeptidase 1 Homo sapiens 60-63 30339177-8 2018 Two additional genome-wide significant modifiers of plasma homocysteine were found in the region of the dipeptidase 1 (DPEP1) gene on chromosome 16 and the Twist neighbor B (TWISTNB) gene on chromosome 7. Homocysteine 59-71 dipeptidase 1 Homo sapiens 104-117 30339177-8 2018 Two additional genome-wide significant modifiers of plasma homocysteine were found in the region of the dipeptidase 1 (DPEP1) gene on chromosome 16 and the Twist neighbor B (TWISTNB) gene on chromosome 7. Homocysteine 59-71 dipeptidase 1 Homo sapiens 119-124 30406140-1 2018 Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) is an effective anti-inflammatory drug in treating rheumatoid arthritis (RA) for over 15 years in China. methylene diphosphonate 30-53 dipeptidase 1 Homo sapiens 60-63 30406140-7 2018 Micro-CT analyses showed that (1) 99Tc-MDP reversed glucocorticoid induced bone microarchitecture destruction by increasing BV/TV, Tb.Th, and Tb.N and decreasing BS/BV, Tb.Sp, and TBPf; (2) effect of 99Tc-MDP increased as its dosage increased; and (3) 99Tc-MDP could improve cortical bone thickness while MDP failed to do so. Thorium 134-136 dipeptidase 1 Homo sapiens 39-42 30406140-7 2018 Micro-CT analyses showed that (1) 99Tc-MDP reversed glucocorticoid induced bone microarchitecture destruction by increasing BV/TV, Tb.Th, and Tb.N and decreasing BS/BV, Tb.Sp, and TBPf; (2) effect of 99Tc-MDP increased as its dosage increased; and (3) 99Tc-MDP could improve cortical bone thickness while MDP failed to do so. Terbium 131-133 dipeptidase 1 Homo sapiens 39-42 30406140-7 2018 Micro-CT analyses showed that (1) 99Tc-MDP reversed glucocorticoid induced bone microarchitecture destruction by increasing BV/TV, Tb.Th, and Tb.N and decreasing BS/BV, Tb.Sp, and TBPf; (2) effect of 99Tc-MDP increased as its dosage increased; and (3) 99Tc-MDP could improve cortical bone thickness while MDP failed to do so. Terbium 142-144 dipeptidase 1 Homo sapiens 39-42 30406140-7 2018 Micro-CT analyses showed that (1) 99Tc-MDP reversed glucocorticoid induced bone microarchitecture destruction by increasing BV/TV, Tb.Th, and Tb.N and decreasing BS/BV, Tb.Sp, and TBPf; (2) effect of 99Tc-MDP increased as its dosage increased; and (3) 99Tc-MDP could improve cortical bone thickness while MDP failed to do so. TFF2 protein, human 172-174 dipeptidase 1 Homo sapiens 39-42 30406140-7 2018 Micro-CT analyses showed that (1) 99Tc-MDP reversed glucocorticoid induced bone microarchitecture destruction by increasing BV/TV, Tb.Th, and Tb.N and decreasing BS/BV, Tb.Sp, and TBPf; (2) effect of 99Tc-MDP increased as its dosage increased; and (3) 99Tc-MDP could improve cortical bone thickness while MDP failed to do so. tbpf 180-184 dipeptidase 1 Homo sapiens 39-42 30031056-1 2018 OBJECTIVES: The amounts of calcium salt of 10-methacryloyloxydecyl dihydrogen phosphate (MDP-Ca salt) and dicalcium phosphate dihydride (DCPD) with an amorphous phase produced by the demineralisation of enamel and dentin were determined using commercial MDP-based 2-hydroxyethyl methacrylate (HEMA)-containing and HEMA-free all-in-one adhesives. calcium salt) 27-39 dipeptidase 1 Homo sapiens 89-92 30031056-1 2018 OBJECTIVES: The amounts of calcium salt of 10-methacryloyloxydecyl dihydrogen phosphate (MDP-Ca salt) and dicalcium phosphate dihydride (DCPD) with an amorphous phase produced by the demineralisation of enamel and dentin were determined using commercial MDP-based 2-hydroxyethyl methacrylate (HEMA)-containing and HEMA-free all-in-one adhesives. calcium salt) 27-39 dipeptidase 1 Homo sapiens 254-257 30031056-1 2018 OBJECTIVES: The amounts of calcium salt of 10-methacryloyloxydecyl dihydrogen phosphate (MDP-Ca salt) and dicalcium phosphate dihydride (DCPD) with an amorphous phase produced by the demineralisation of enamel and dentin were determined using commercial MDP-based 2-hydroxyethyl methacrylate (HEMA)-containing and HEMA-free all-in-one adhesives. methacryloyloxydecyl dihydrogen phosphate 43-87 dipeptidase 1 Homo sapiens 89-92 30031056-4 2018 The reactant residues of each adhesive were prepared after interacting with enamel and dentin samples for 60 s. The amounts of MDP-Ca salt and amorphous DCPD produced were determined using a phosphorous-31 nuclear magnetic resonance technique. ca salt 131-138 dipeptidase 1 Homo sapiens 127-130 25755052-7 2015 Near complete inhibition of LY404039 formation was observed in intestinal and kidney homogenate and human plasma with the selective dehydropeptidase1 (DPEP1) inhibitor cilastatin. 4-aminho-2-thiabicyclo(3.1.0)hexane-4,6-dicarboxylic acid 28-36 dipeptidase 1 Homo sapiens 132-149 28656306-1 2017 The aim of the present study was to examine the influence of technetium methylenediphosphonate (99Tc-MDP) on the proliferation and differentiation of human osteoblasts. Technetium Tc 99m Medronate 61-94 dipeptidase 1 Homo sapiens 101-104 27988825-2 2017 The aim of this study was to evaluate the influence of milk and dairy products (MDP) on Pb levels in blood (B-Pb), plasma (P-Pb), and urine (U-Pb), in workers from automotive battery industries in Brazil. Lead 88-90 dipeptidase 1 Homo sapiens 80-83 27988825-2 2017 The aim of this study was to evaluate the influence of milk and dairy products (MDP) on Pb levels in blood (B-Pb), plasma (P-Pb), and urine (U-Pb), in workers from automotive battery industries in Brazil. b-pb 108-112 dipeptidase 1 Homo sapiens 80-83 27988825-6 2017 Multivariable linear regressions showed a significant influence of MDP intake on B-Pb (beta = -0.10; p = 0.012) and P-Pb (beta = -0.16; p < 0.010), while no significance was seen on U-Pb. Boron 81-83 dipeptidase 1 Homo sapiens 67-70 27988825-6 2017 Multivariable linear regressions showed a significant influence of MDP intake on B-Pb (beta = -0.10; p = 0.012) and P-Pb (beta = -0.16; p < 0.010), while no significance was seen on U-Pb. u-pb 185-189 dipeptidase 1 Homo sapiens 67-70 27988825-7 2017 Our results suggest that MDP consumption may modulate Pb levels in individuals highly exposed to the metal; these findings may be due to the Pb-Ca interactions, since the adverse effects of Pb are partially based on its interference with Ca metabolism and proper Ca supplementation may help to reduce the adverse health effects induced by Pb exposure. Lead 54-56 dipeptidase 1 Homo sapiens 25-28 27988825-7 2017 Our results suggest that MDP consumption may modulate Pb levels in individuals highly exposed to the metal; these findings may be due to the Pb-Ca interactions, since the adverse effects of Pb are partially based on its interference with Ca metabolism and proper Ca supplementation may help to reduce the adverse health effects induced by Pb exposure. Metals 101-106 dipeptidase 1 Homo sapiens 25-28 27988825-7 2017 Our results suggest that MDP consumption may modulate Pb levels in individuals highly exposed to the metal; these findings may be due to the Pb-Ca interactions, since the adverse effects of Pb are partially based on its interference with Ca metabolism and proper Ca supplementation may help to reduce the adverse health effects induced by Pb exposure. Lead 141-143 dipeptidase 1 Homo sapiens 25-28 27988825-7 2017 Our results suggest that MDP consumption may modulate Pb levels in individuals highly exposed to the metal; these findings may be due to the Pb-Ca interactions, since the adverse effects of Pb are partially based on its interference with Ca metabolism and proper Ca supplementation may help to reduce the adverse health effects induced by Pb exposure. Lead 141-143 dipeptidase 1 Homo sapiens 25-28 27988825-7 2017 Our results suggest that MDP consumption may modulate Pb levels in individuals highly exposed to the metal; these findings may be due to the Pb-Ca interactions, since the adverse effects of Pb are partially based on its interference with Ca metabolism and proper Ca supplementation may help to reduce the adverse health effects induced by Pb exposure. Lead 141-143 dipeptidase 1 Homo sapiens 25-28 28680204-7 2017 In this case series, we highlight the importance of a 99mtechnetium methylene diphosphonate (99mTc MDP) triple phase bone scan in cases of severe frostbite to precisely delineate the ischaemic and reperfusion zones, so as to help the surgeons in carefully deciding if amputation is required and the level of amputation in such cases. 99mtechnetium methylene diphosphonate 54-91 dipeptidase 1 Homo sapiens 99-102 28467265-0 2017 Bonding Polycrystalline Zirconia With 10-MDP-containing Adhesives. polycrystalline zirconia 8-32 dipeptidase 1 Homo sapiens 41-44 28467265-3 2017 The 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) monomer was added at 0wt%, 3wt%, 6wt%, 9wt%, 12wt%, or 15wt%. methacryloyloxydecyl dihydrogen phosphate 4-48 dipeptidase 1 Homo sapiens 53-56 28413640-1 2017 Dipeptidase 1 (DPEP1) is a zinc-dependent metalloproteinase that is fundamental in glutathione and leukotriene metabolism. Glutathione 83-94 dipeptidase 1 Homo sapiens 0-13 28413640-1 2017 Dipeptidase 1 (DPEP1) is a zinc-dependent metalloproteinase that is fundamental in glutathione and leukotriene metabolism. Glutathione 83-94 dipeptidase 1 Homo sapiens 15-20 28413640-1 2017 Dipeptidase 1 (DPEP1) is a zinc-dependent metalloproteinase that is fundamental in glutathione and leukotriene metabolism. Leukotrienes 99-110 dipeptidase 1 Homo sapiens 0-13 28413640-1 2017 Dipeptidase 1 (DPEP1) is a zinc-dependent metalloproteinase that is fundamental in glutathione and leukotriene metabolism. Leukotrienes 99-110 dipeptidase 1 Homo sapiens 15-20 27170456-6 2016 In biodistribution studies, all of the (99m)Tc complexes exhibited high bone uptake superior to that of 25, which is the directly (99m)Tc-labeled bisphosphonate 3, and comparable to that of (99m)Tc-methylene diphosphonate ((99m)Tc-MDP). Technetium 44-46 dipeptidase 1 Homo sapiens 231-234 27834323-0 2016 Association of CTG repeat polymorphism in carnosine dipeptidase 1 (CNDP1) gene with diabetic nephropathy in north Indians. ctg 15-18 dipeptidase 1 Homo sapiens 52-65 26027769-2 2015 On combined single-photon emission computed tomography and computed tomography (SPECT-CT), increased technetium-99m methylene diphosphonate (99mTc MDP) activity at these articulations is not uncommon. technetium-99m methylene diphosphonate 101-139 dipeptidase 1 Homo sapiens 147-150 26148143-1 2017 In bone scan patients with dialysis-treated chronic kidney disease (CKD) and hyperparathyroidism, soft tissue accumulation of technetium-99 m hydroxy/methylene diphosphonate (Tc-99 m-HDP/MDP) has been reported primarily in case reports and usually explained by hypercalcaemia and/or hyperphosphataemia. technetium-99 m hydroxy/methylene diphosphonate 126-173 dipeptidase 1 Homo sapiens 175-190 26148143-2 2017 As human vascular smooth muscle cells produce hydroxyapatite during cell culture with increased phosphate levels and as Tc-99 m-HDP/MDP primarily binds to hydroxyapatite, we hypothesized that soft tissue accumulation would be found in patients with hyperphosphataemia. Durapatite 155-169 dipeptidase 1 Homo sapiens 132-135 27773341-1 2017 OBJECTIVE: The 10-methacryloyloxydecyl dihydrogen phosphate (MDP) (EX adhesives)-based one-step self-etch adhesives have become widely utilized due to their simplified application procedures. methacryloyloxydecyl dihydrogen phosphate 15-59 dipeptidase 1 Homo sapiens 61-64 27773341-2 2017 The aim of this study was to determine the type of the molecular species of calcium salts of MDP (MDP-Ca salts) that form a layered structure and to understand the layering mechanism of MDP-Ca salts. calcium salts 76-89 dipeptidase 1 Homo sapiens 93-96 27773341-2 2017 The aim of this study was to determine the type of the molecular species of calcium salts of MDP (MDP-Ca salts) that form a layered structure and to understand the layering mechanism of MDP-Ca salts. calcium salts 76-89 dipeptidase 1 Homo sapiens 98-110 27773341-2 2017 The aim of this study was to determine the type of the molecular species of calcium salts of MDP (MDP-Ca salts) that form a layered structure and to understand the layering mechanism of MDP-Ca salts. calcium salts 76-89 dipeptidase 1 Homo sapiens 186-198 27773341-6 2017 RESULTS: The molecular species of MDP-Ca salts that form a layered structure were determined as mono-calcium salt (MCS-MD) and di-calcium salts of the MDP dimer (DCS-MD). mono-calcium salt 96-113 dipeptidase 1 Homo sapiens 34-37 27773341-6 2017 RESULTS: The molecular species of MDP-Ca salts that form a layered structure were determined as mono-calcium salt (MCS-MD) and di-calcium salts of the MDP dimer (DCS-MD). di-calcium 127-137 dipeptidase 1 Homo sapiens 34-37 27773341-6 2017 RESULTS: The molecular species of MDP-Ca salts that form a layered structure were determined as mono-calcium salt (MCS-MD) and di-calcium salts of the MDP dimer (DCS-MD). di-calcium 127-137 dipeptidase 1 Homo sapiens 151-154 27773341-8 2017 A mono-calcium salt of the MDP monomer (MCS-MM), a predominant molecular species, was not contributed to a layered-structure formation, since the intensities of characteristic XRD peaks are limited by the production of DCS-MD and MCS-MD. mono-calcium salt 2-19 dipeptidase 1 Homo sapiens 27-30 26824987-8 2016 Furthermore, cilastatin, a DPEP1 inhibitor, suppressed the invasion and metastasis of DPEP1-expressing cells. Cilastatin 13-23 dipeptidase 1 Homo sapiens 27-32 26824987-8 2016 Furthermore, cilastatin, a DPEP1 inhibitor, suppressed the invasion and metastasis of DPEP1-expressing cells. Cilastatin 13-23 dipeptidase 1 Homo sapiens 86-91 26824987-9 2016 DPEP1 inhibited the leukotriene D4 signaling pathway and increased the expression of E-cadherin. Leukotrienes 20-31 dipeptidase 1 Homo sapiens 0-5 25755052-7 2015 Near complete inhibition of LY404039 formation was observed in intestinal and kidney homogenate and human plasma with the selective dehydropeptidase1 (DPEP1) inhibitor cilastatin. 4-aminho-2-thiabicyclo(3.1.0)hexane-4,6-dicarboxylic acid 28-36 dipeptidase 1 Homo sapiens 151-156 25755052-7 2015 Near complete inhibition of LY404039 formation was observed in intestinal and kidney homogenate and human plasma with the selective dehydropeptidase1 (DPEP1) inhibitor cilastatin. Cilastatin 168-178 dipeptidase 1 Homo sapiens 132-149 25755052-7 2015 Near complete inhibition of LY404039 formation was observed in intestinal and kidney homogenate and human plasma with the selective dehydropeptidase1 (DPEP1) inhibitor cilastatin. Cilastatin 168-178 dipeptidase 1 Homo sapiens 151-156 25755052-8 2015 Human recombinant DPEP1 was expressed and shown to catalyze the hydrolysis, which was completely inhibited by cilastatin. Cilastatin 110-120 dipeptidase 1 Homo sapiens 18-23 25755052-9 2015 These studies demonstrate pomaglumetad methionil can be converted to LY404039 via one or multiple enzymes completely inhibited by cilastatin, likely DPEP1, in plasma, the intestine, and the kidney, with the plasma and kidney involved in the clearance of the circulating prodrug. pomaglumetad methionil 26-48 dipeptidase 1 Homo sapiens 149-154 25755052-9 2015 These studies demonstrate pomaglumetad methionil can be converted to LY404039 via one or multiple enzymes completely inhibited by cilastatin, likely DPEP1, in plasma, the intestine, and the kidney, with the plasma and kidney involved in the clearance of the circulating prodrug. 4-aminho-2-thiabicyclo(3.1.0)hexane-4,6-dicarboxylic acid 69-77 dipeptidase 1 Homo sapiens 149-154 25755052-9 2015 These studies demonstrate pomaglumetad methionil can be converted to LY404039 via one or multiple enzymes completely inhibited by cilastatin, likely DPEP1, in plasma, the intestine, and the kidney, with the plasma and kidney involved in the clearance of the circulating prodrug. Cilastatin 130-140 dipeptidase 1 Homo sapiens 149-154 25753080-3 2015 The molecular species of calcium salts of MDP (MDP-Ca salts) produced by decalcification of enamel or dentin were determined based on the XRD and (31)P NMR analysis results of these three types of synthesized MDP-Ca salts. Calcium 25-32 dipeptidase 1 Homo sapiens 47-50 26504822-3 2015 Cilastatin is a dehydropeptidase I inhibitor that acts on the brush border membrane of the proximal tubule to prevent accumulation of imipenem and toxicity. Cilastatin 0-10 dipeptidase 1 Homo sapiens 16-34 26504822-3 2015 Cilastatin is a dehydropeptidase I inhibitor that acts on the brush border membrane of the proximal tubule to prevent accumulation of imipenem and toxicity. Imipenem 134-142 dipeptidase 1 Homo sapiens 16-34 25753080-0 2015 Determination of molecular species of calcium salts of MDP produced through decalcification of enamel and dentin by MDP-based one-step adhesive. calcium salts 38-51 dipeptidase 1 Homo sapiens 55-58 25753080-0 2015 Determination of molecular species of calcium salts of MDP produced through decalcification of enamel and dentin by MDP-based one-step adhesive. calcium salts 38-51 dipeptidase 1 Homo sapiens 116-119 25753080-1 2015 Enamel and dentin particles were added to an experimental 10-methacryloyloxydecyl dihydrogen phosphate (MDP)-based one-step adhesive to react for 30 s. After enamel and dentin reactants were analyzed using X-ray diffraction (XRD) and phosphorus-31 nuclear magnetic resonance ((31)P NMR) techniques, curve-fitting analysis was performed on the (31)P NMR spectra of enamel and dentin reactants. methacryloyloxydecyl dihydrogen phosphate 58-102 dipeptidase 1 Homo sapiens 104-107 25753080-2 2015 By varying the molar ratio of calcium chloride to MDP, a series of three types of MDP-Ca salts were synthesized. Calcium Chloride 30-46 dipeptidase 1 Homo sapiens 82-85 25753080-3 2015 The molecular species of calcium salts of MDP (MDP-Ca salts) produced by decalcification of enamel or dentin were determined based on the XRD and (31)P NMR analysis results of these three types of synthesized MDP-Ca salts. Calcium 25-32 dipeptidase 1 Homo sapiens 42-45 25753080-3 2015 The molecular species of calcium salts of MDP (MDP-Ca salts) produced by decalcification of enamel or dentin were determined based on the XRD and (31)P NMR analysis results of these three types of synthesized MDP-Ca salts. Calcium 25-32 dipeptidase 1 Homo sapiens 47-59 25753080-5 2015 The molecular species of MDP-Ca salts produced by enamel and dentin were mono-calcium salts of MDP monomer and MDP dimer. Calcium 78-85 dipeptidase 1 Homo sapiens 25-28 25753080-5 2015 The molecular species of MDP-Ca salts produced by enamel and dentin were mono-calcium salts of MDP monomer and MDP dimer. Calcium 78-85 dipeptidase 1 Homo sapiens 95-98 25753080-5 2015 The molecular species of MDP-Ca salts produced by enamel and dentin were mono-calcium salts of MDP monomer and MDP dimer. Calcium 78-85 dipeptidase 1 Homo sapiens 95-98 25753080-6 2015 In addition, dentin produced a di-calcium of MDP dimer. di-calcium 31-41 dipeptidase 1 Homo sapiens 45-48 25397621-2 2014 Methylene diphosphonate-technetium-99m ((99m)Tc-MDP) 3-phase bone scan is considered the most sensitive imaging method for the detection of jaw osteonecrosis at an early stage. methylene diphosphonate 0-23 dipeptidase 1 Homo sapiens 48-51 25568576-1 2014 AIM: The aim of our study is to assess the diagnostic value of Technituim-(99m)-Methyle diphosphonate ((99m)Tc-MDP) Bone scintigraphy in the assessment of children with back pain. technituim-(99m)-methyle diphosphonate 63-101 dipeptidase 1 Homo sapiens 111-114 25397621-2 2014 Methylene diphosphonate-technetium-99m ((99m)Tc-MDP) 3-phase bone scan is considered the most sensitive imaging method for the detection of jaw osteonecrosis at an early stage. Technetium-99 24-37 dipeptidase 1 Homo sapiens 48-51 24864096-6 2014 Introduction of a methyl group at the system of coupled rings: beta-lactam and pyrrolidine, solved the problem of degradation by the dehydropeptidase-I (DHP-I). beta-Lactams 63-74 dipeptidase 1 Homo sapiens 133-151 24864096-6 2014 Introduction of a methyl group at the system of coupled rings: beta-lactam and pyrrolidine, solved the problem of degradation by the dehydropeptidase-I (DHP-I). beta-Lactams 63-74 dipeptidase 1 Homo sapiens 153-158 24864096-6 2014 Introduction of a methyl group at the system of coupled rings: beta-lactam and pyrrolidine, solved the problem of degradation by the dehydropeptidase-I (DHP-I). pyrrolidine 79-90 dipeptidase 1 Homo sapiens 133-151 24864096-6 2014 Introduction of a methyl group at the system of coupled rings: beta-lactam and pyrrolidine, solved the problem of degradation by the dehydropeptidase-I (DHP-I). pyrrolidine 79-90 dipeptidase 1 Homo sapiens 153-158 24790760-11 2014 DPEP1 acts via leukotrienes on TRPC6 and results in increased podocyte motility and proteinuria. Leukotrienes 15-27 dipeptidase 1 Homo sapiens 0-5 24882111-1 2014 Five experimental 10-methacryloyloxydecyl dihydrogen phosphate (MDP)-based one-step self-etch adhesives were designed by varying amounts of MDP. methacryloyloxydecyl dihydrogen phosphate 18-62 dipeptidase 1 Homo sapiens 64-67 24882111-2 2014 The aim of this study was to examine the effect of the quantity of calcium salt of MDP (MDP-Ca) salt produced by demineralization on the bond durability between experimental one-step adhesives and enamel or dentin. calcium salt) 67-79 dipeptidase 1 Homo sapiens 83-86 24882111-2 2014 The aim of this study was to examine the effect of the quantity of calcium salt of MDP (MDP-Ca) salt produced by demineralization on the bond durability between experimental one-step adhesives and enamel or dentin. calcium salt) 67-79 dipeptidase 1 Homo sapiens 88-94 23147735-5 2013 SM-295291 and SM-369926 showed intravenous pharmacokinetics similar to those of meropenem in terms of half-life in monkeys (0.4 h) and were stable against human dehydropeptidase I. Samarium 0-2 dipeptidase 1 Homo sapiens 161-179 24370054-1 2013 The purpose of this study was to explore the effect of NOD2 signalling pathway activated by muramyl dipeptide (MDP) on the immunomodulation effect of human monocyte-derived dendritic cells (DC) loaded with leukemia cell lysates. Acetylmuramyl-Alanyl-Isoglutamine 92-109 dipeptidase 1 Homo sapiens 111-114 23147735-5 2013 SM-295291 and SM-369926 showed intravenous pharmacokinetics similar to those of meropenem in terms of half-life in monkeys (0.4 h) and were stable against human dehydropeptidase I. Samarium 14-16 dipeptidase 1 Homo sapiens 161-179 17914811-3 2007 Thiamine diphosphate (TDP) and uridine 5"-diphosphate (5"-UDP) form 1:1 bidentate {Palpha,Pbeta} chelates, in which the MDP binds Re(I) via Palpha and Pbeta phosphate groups. Thiamine Pyrophosphate 0-20 dipeptidase 1 Homo sapiens 120-123 23919069-6 2012 (99m)Tc-WBCs showed better Sn, Sp, and accuracy in group I (95%, 93.1% and 93.9%, respectively) compared to 40%, 41.4%, and 40.8% for plain X-ray and 90%, 62%, and 73.5% respectively for (99m)Tc-MDP. Technetium 5-7 dipeptidase 1 Homo sapiens 195-198 23919069-7 2012 On the other hand, (99m)Tc-MDP proved to have best Sn 100% versus 78.3% and 30.4% for (99m)Tc-WBCs and plain X-ray respectively. Technetium 24-26 dipeptidase 1 Homo sapiens 27-30 23258559-5 2012 As NOD agonists, N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP; NOD 2) and gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP; NOD 1) were encapsulated. Acetylmuramyl-Alanyl-Isoglutamine 17-56 dipeptidase 1 Homo sapiens 58-61 21440333-2 2011 The authors describe three cases of accidental intraarterial injection of Tc-(99m) methylene diphosphonate ((99m)Tc-MDP) on the antecubital region and discuss the findings and differential diagnosis. Technetium Tc 99m Medronate 74-106 dipeptidase 1 Homo sapiens 116-119 21193884-1 2010 Technetium-extraosseous accumulation of technetium-99m-methyl diphosphonate ((99m)Tc-MDP) on bone scan is not usual. technetium-99m-methyl diphosphonate 40-75 dipeptidase 1 Homo sapiens 85-88 20435919-14 2010 Our findings suggest that the affinity of cilastatin for renal dipeptidase makes this effect specific for proximal tubular cells and may be related to a reduction in intracellular drug accumulation. Cilastatin 42-52 dipeptidase 1 Homo sapiens 57-74 20484183-1 2010 UNLABELLED: The aim of the study was to optimize imaging positions of (99m)Tc-methylene diphosphonate ((99m)Tc-MDP) 3-phase bone scanning for the accurate localization of foot pathology in patients with trauma and diabetes-related complications. tc-methylene diphosphonate 75-101 dipeptidase 1 Homo sapiens 111-114 20000809-1 2010 Human renal dipeptidase, an enzyme associated with glutathione metabolism and the hydrolysis of beta-lactams, is similar in sequence to a cluster of approximately 400 microbial proteins currently annotated as nonspecific dipeptidases within the amidohydrolase superfamily. Glutathione 51-62 dipeptidase 1 Homo sapiens 6-23 20000809-1 2010 Human renal dipeptidase, an enzyme associated with glutathione metabolism and the hydrolysis of beta-lactams, is similar in sequence to a cluster of approximately 400 microbial proteins currently annotated as nonspecific dipeptidases within the amidohydrolase superfamily. beta-Lactams 96-108 dipeptidase 1 Homo sapiens 6-23 18931951-2 2009 Human renal dipeptidase (MDP), the only human beta-lactamase known to date, is a homodimeric enzyme, which contains six cysteine residues per monomer. Cysteine 120-128 dipeptidase 1 Homo sapiens 6-23 18534398-2 2009 This study is a prospective study to assess patellar viability using Technetium-99m methylene diphosphate (Tc-99m MDP) scintigraphy. technetium-99m methylene diphosphate 69-105 dipeptidase 1 Homo sapiens 114-117 20031578-0 2009 Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women"s Genome Health Study. Homocysteine 61-73 dipeptidase 1 Homo sapiens 43-48 22363658-8 2012 We further demonstrated that overexpression of DPEP1 suppressed tumor cells invasiveness and increased sensitivity to chemotherapeutic agent Gemcitabine. gemcitabine 141-152 dipeptidase 1 Homo sapiens 47-52 22363658-9 2012 Our data also showed that growth factor EGF treatment decreased DPEP1 expression and MEK1/2 inhibitor AZD6244 increased DPEP1 expression in vitro, indicating a potential mechanism for DPEP1 gene regulation. AZD 6244 102-109 dipeptidase 1 Homo sapiens 120-125 22363658-9 2012 Our data also showed that growth factor EGF treatment decreased DPEP1 expression and MEK1/2 inhibitor AZD6244 increased DPEP1 expression in vitro, indicating a potential mechanism for DPEP1 gene regulation. AZD 6244 102-109 dipeptidase 1 Homo sapiens 120-125 22363658-10 2012 Therefore, we provide evidence that DPEP1 plays a role in pancreatic cancer aggressiveness and predicts outcome in patients with resected PDAC. pdac 138-142 dipeptidase 1 Homo sapiens 36-41 21063232-1 2011 OBJECTIVE: To explore the effects of technetium-99 methylenediphosphonate (99Tc-MDP) on cell proliferation, hyaluronic acid (HA) synthesis and the expressions of human leucocyte antigen-DR (HLA-DR), intercellular adhesion molecule-1 (ICAM-1) on cultured retro-ocular fibroblasts (RFs) from patients with Graves" ophthalmopathy. technetium-99 methylenediphosphonate 37-73 dipeptidase 1 Homo sapiens 80-83 21193884-1 2010 Technetium-extraosseous accumulation of technetium-99m-methyl diphosphonate ((99m)Tc-MDP) on bone scan is not usual. Technetium 0-10 dipeptidase 1 Homo sapiens 85-88 19879002-0 2010 Dipeptide hydrolysis by the dinuclear zinc enzyme human renal dipeptidase: mechanistic insights from DFT calculations. Dipeptides 0-9 dipeptidase 1 Homo sapiens 56-73 18586631-2 2008 Technetium methylene diphosphonate scan ([(99m)Tc]MDP) is one of the most popular radiotracers used for that purpose. Technetium Tc 99m Medronate 0-34 dipeptidase 1 Homo sapiens 50-53 17914811-3 2007 Thiamine diphosphate (TDP) and uridine 5"-diphosphate (5"-UDP) form 1:1 bidentate {Palpha,Pbeta} chelates, in which the MDP binds Re(I) via Palpha and Pbeta phosphate groups. Uridine Diphosphate 31-53 dipeptidase 1 Homo sapiens 120-123 17914811-3 2007 Thiamine diphosphate (TDP) and uridine 5"-diphosphate (5"-UDP) form 1:1 bidentate {Palpha,Pbeta} chelates, in which the MDP binds Re(I) via Palpha and Pbeta phosphate groups. Uridine Diphosphate 55-61 dipeptidase 1 Homo sapiens 120-123 17914811-3 2007 Thiamine diphosphate (TDP) and uridine 5"-diphosphate (5"-UDP) form 1:1 bidentate {Palpha,Pbeta} chelates, in which the MDP binds Re(I) via Palpha and Pbeta phosphate groups. pbeta phosphate 151-166 dipeptidase 1 Homo sapiens 120-123 17914811-6 2007 31Palpha-31Palpha EXSY cross-peaks indicate that the fac-[Re(CO)3(H2O)({Palpha,Pbeta}MDP)]- isomers interchange slowly on the NMR time scale, with an average k approximately equal to 0.8 s(-1) at 32 degrees C; the EXSY cross-peaks could arise from chirality changes at only Re(I) or at only Palpha. Water 66-69 dipeptidase 1 Homo sapiens 85-88 17914811-10 2007 The similarity of the rate constants for interchange of fac-[Re(CO)3(H2O)({Palpha,Pbeta}MDP)]- and fac-[Re(CO)3(H2O)({N7,Pbeta}GDP)]- adducts suggest strongly that interchange of Pbeta and H2O coordination positions accounts for the EXSY cross-peaks present in the spectra of all adducts. co) 64-67 dipeptidase 1 Homo sapiens 88-91 17914811-10 2007 The similarity of the rate constants for interchange of fac-[Re(CO)3(H2O)({Palpha,Pbeta}MDP)]- and fac-[Re(CO)3(H2O)({N7,Pbeta}GDP)]- adducts suggest strongly that interchange of Pbeta and H2O coordination positions accounts for the EXSY cross-peaks present in the spectra of all adducts. Water 69-72 dipeptidase 1 Homo sapiens 88-91 17914811-10 2007 The similarity of the rate constants for interchange of fac-[Re(CO)3(H2O)({Palpha,Pbeta}MDP)]- and fac-[Re(CO)3(H2O)({N7,Pbeta}GDP)]- adducts suggest strongly that interchange of Pbeta and H2O coordination positions accounts for the EXSY cross-peaks present in the spectra of all adducts. co)3 64-68 dipeptidase 1 Homo sapiens 88-91 17306533-0 2007 Design and synthesis of novel prodrugs of 2"-deoxy-2"-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues. 2'-deoxy-2'-methylenecytidine 42-73 dipeptidase 1 Homo sapiens 87-107 17615681-0 2007 Release of renal dipeptidase from glycosylphosphatidylinositol anchor by insulin-triggered phospholipase C/intracellular Ca2+. Glycosylphosphatidylinositols 34-62 dipeptidase 1 Homo sapiens 11-28 17306533-2 2007 Novel prodrugs of 2"-deoxy-2"-methylidenecytidine (DMDC) including compound 23 that are activated by membrane dipeptidase (MDP) preferentially in tumor tissue were designed and synthesized to generate the active drug, DMDC, after hydrolysis of the dipeptide bond followed by spontaneous cyclization of the promoiety. 2'-deoxy-2'-methylenecytidine 18-49 dipeptidase 1 Homo sapiens 101-121 17306533-2 2007 Novel prodrugs of 2"-deoxy-2"-methylidenecytidine (DMDC) including compound 23 that are activated by membrane dipeptidase (MDP) preferentially in tumor tissue were designed and synthesized to generate the active drug, DMDC, after hydrolysis of the dipeptide bond followed by spontaneous cyclization of the promoiety. 2'-deoxy-2'-methylenecytidine 18-49 dipeptidase 1 Homo sapiens 123-126 17306533-2 2007 Novel prodrugs of 2"-deoxy-2"-methylidenecytidine (DMDC) including compound 23 that are activated by membrane dipeptidase (MDP) preferentially in tumor tissue were designed and synthesized to generate the active drug, DMDC, after hydrolysis of the dipeptide bond followed by spontaneous cyclization of the promoiety. 2'-deoxy-2'-methylenecytidine 51-55 dipeptidase 1 Homo sapiens 101-121 17306533-2 2007 Novel prodrugs of 2"-deoxy-2"-methylidenecytidine (DMDC) including compound 23 that are activated by membrane dipeptidase (MDP) preferentially in tumor tissue were designed and synthesized to generate the active drug, DMDC, after hydrolysis of the dipeptide bond followed by spontaneous cyclization of the promoiety. 2'-deoxy-2'-methylenecytidine 51-55 dipeptidase 1 Homo sapiens 123-126 17306533-2 2007 Novel prodrugs of 2"-deoxy-2"-methylidenecytidine (DMDC) including compound 23 that are activated by membrane dipeptidase (MDP) preferentially in tumor tissue were designed and synthesized to generate the active drug, DMDC, after hydrolysis of the dipeptide bond followed by spontaneous cyclization of the promoiety. 2'-deoxy-2'-methylenecytidine 218-222 dipeptidase 1 Homo sapiens 101-121 17306533-2 2007 Novel prodrugs of 2"-deoxy-2"-methylidenecytidine (DMDC) including compound 23 that are activated by membrane dipeptidase (MDP) preferentially in tumor tissue were designed and synthesized to generate the active drug, DMDC, after hydrolysis of the dipeptide bond followed by spontaneous cyclization of the promoiety. 2'-deoxy-2'-methylenecytidine 218-222 dipeptidase 1 Homo sapiens 123-126 17306533-2 2007 Novel prodrugs of 2"-deoxy-2"-methylidenecytidine (DMDC) including compound 23 that are activated by membrane dipeptidase (MDP) preferentially in tumor tissue were designed and synthesized to generate the active drug, DMDC, after hydrolysis of the dipeptide bond followed by spontaneous cyclization of the promoiety. Dipeptides 248-257 dipeptidase 1 Homo sapiens 101-121 17306533-2 2007 Novel prodrugs of 2"-deoxy-2"-methylidenecytidine (DMDC) including compound 23 that are activated by membrane dipeptidase (MDP) preferentially in tumor tissue were designed and synthesized to generate the active drug, DMDC, after hydrolysis of the dipeptide bond followed by spontaneous cyclization of the promoiety. Dipeptides 248-257 dipeptidase 1 Homo sapiens 123-126 17264777-1 2007 BACKGROUND: The measurement of protein binding is essential for accurate quantitative studies of skeletal kinetics using Tc-methylene diphosphonate (Tc-MDP). tc-methylene diphosphonate 121-147 dipeptidase 1 Homo sapiens 152-155 17160160-2 2006 A single photon emission tomography scan performed after the intravenous injection of 740 MBq of technetium-99m methylene-diphosphonate ((99m)Tc-MDP) showed abnormal uptake throughout the right lung. technetium-99m methylene-diphosphonate 97-135 dipeptidase 1 Homo sapiens 145-148 16973246-3 2006 Of these carbapenems, 1d showed the best combination of antibacterial activity and stability to dehydropeptidase-I (DHP-I). Carbapenems 9-20 dipeptidase 1 Homo sapiens 96-114 16973246-3 2006 Of these carbapenems, 1d showed the best combination of antibacterial activity and stability to dehydropeptidase-I (DHP-I). Carbapenems 9-20 dipeptidase 1 Homo sapiens 116-121 16304447-2 2005 The functional monomer 10-MDP interacts most intensively with hydroxyapatite, and its calcium salt appeared most hydrolytically stable, as compared with 4-MET and phenyl-P. Durapatite 62-76 dipeptidase 1 Homo sapiens 26-29 16469632-7 2006 MBC increased from 215.6 +/- 58.8 cc to 338.3 +/- 98.4 cc (p < 0.01), MDP decreased from 43 +/- 13.7 cm H2O to 21.6 +/- 10.5 cm H2O (p < 0.01) and compliance increased from 5.2 +/- 2.6 ml/cm H2O to 13 +/- 6.9 ml/cm H2O (p < 0.01). Water 107-110 dipeptidase 1 Homo sapiens 73-76 16373855-4 2005 One such vascular receptor of normal lung endothelium is membrane dipeptidase (MDP), which was found by in vivo phage display to bind the tripeptide motif gly-phe-glu (GFE). tripeptide K-26 138-148 dipeptidase 1 Homo sapiens 79-82 16373855-4 2005 One such vascular receptor of normal lung endothelium is membrane dipeptidase (MDP), which was found by in vivo phage display to bind the tripeptide motif gly-phe-glu (GFE). Gly-Phe-Glu 155-166 dipeptidase 1 Homo sapiens 79-82 16373855-4 2005 One such vascular receptor of normal lung endothelium is membrane dipeptidase (MDP), which was found by in vivo phage display to bind the tripeptide motif gly-phe-glu (GFE). 1-(3,4-dichlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine 168-171 dipeptidase 1 Homo sapiens 79-82 16798918-9 2006 CONCLUSIONS: 99Tc(m)-MDP three-phase bone scans who could be used as a screening test to detect subclinical osteonecrosis in patients who have received bisphosphonates. Diphosphonates 152-167 dipeptidase 1 Homo sapiens 21-24 15979227-3 2006 The addition of hydroxyapatite or dentine to MB and the addition of dentine to UB resulted in the decrease in the peak intensity of the 13C NMR peaks attributed to the methacryloxy decyl phosphoric acid, MDP in the MB or 4-methacryloyloxy ethoxy carbonylphthalic acid, 4-MET in the UB. Durapatite 16-30 dipeptidase 1 Homo sapiens 204-207 15979227-3 2006 The addition of hydroxyapatite or dentine to MB and the addition of dentine to UB resulted in the decrease in the peak intensity of the 13C NMR peaks attributed to the methacryloxy decyl phosphoric acid, MDP in the MB or 4-methacryloyloxy ethoxy carbonylphthalic acid, 4-MET in the UB. BM 79-81 dipeptidase 1 Homo sapiens 204-207 15979227-3 2006 The addition of hydroxyapatite or dentine to MB and the addition of dentine to UB resulted in the decrease in the peak intensity of the 13C NMR peaks attributed to the methacryloxy decyl phosphoric acid, MDP in the MB or 4-methacryloyloxy ethoxy carbonylphthalic acid, 4-MET in the UB. 13c 136-139 dipeptidase 1 Homo sapiens 204-207 15979227-4 2006 This decrease was because the MDP or 4-MET demineralised the tooth and the calcium salts produced from the MDP or 4-MET were precipitated from the MB or UB solution. Calcium 75-82 dipeptidase 1 Homo sapiens 107-110 15979227-4 2006 This decrease was because the MDP or 4-MET demineralised the tooth and the calcium salts produced from the MDP or 4-MET were precipitated from the MB or UB solution. mb 147-149 dipeptidase 1 Homo sapiens 30-33 15979227-4 2006 This decrease was because the MDP or 4-MET demineralised the tooth and the calcium salts produced from the MDP or 4-MET were precipitated from the MB or UB solution. mb 147-149 dipeptidase 1 Homo sapiens 107-110 15979227-4 2006 This decrease was because the MDP or 4-MET demineralised the tooth and the calcium salts produced from the MDP or 4-MET were precipitated from the MB or UB solution. BM 153-155 dipeptidase 1 Homo sapiens 30-33 15979227-4 2006 This decrease was because the MDP or 4-MET demineralised the tooth and the calcium salts produced from the MDP or 4-MET were precipitated from the MB or UB solution. BM 153-155 dipeptidase 1 Homo sapiens 107-110 15979227-6 2006 However, the calcium salts produced by the MDP or 4-MET on the tooth surface would not facilitate retention in bonding, since these calcium salts were merely deposited on to the surface of the tooth. Calcium 13-20 dipeptidase 1 Homo sapiens 43-46 15979227-6 2006 However, the calcium salts produced by the MDP or 4-MET on the tooth surface would not facilitate retention in bonding, since these calcium salts were merely deposited on to the surface of the tooth. calcium salts 13-26 dipeptidase 1 Homo sapiens 43-46 16617402-2 2006 The findings in this case were compared with the intravenously injected methylene disphosphonate technetium-99m ((99m)Tc-MDP) scintigraphic findings and could be interpreted as the result of (99m)Tc-pertechenate through blood communication from the right to the left knee. methylene disphosphonate 72-96 dipeptidase 1 Homo sapiens 121-124 16617402-2 2006 The findings in this case were compared with the intravenously injected methylene disphosphonate technetium-99m ((99m)Tc-MDP) scintigraphic findings and could be interpreted as the result of (99m)Tc-pertechenate through blood communication from the right to the left knee. Technetium-99 97-110 dipeptidase 1 Homo sapiens 121-124 16617402-2 2006 The findings in this case were compared with the intravenously injected methylene disphosphonate technetium-99m ((99m)Tc-MDP) scintigraphic findings and could be interpreted as the result of (99m)Tc-pertechenate through blood communication from the right to the left knee. tc-pertechenate 196-211 dipeptidase 1 Homo sapiens 121-124 15177467-0 2004 Synthesis and evaluation of aminophosphinic acid derivatives as inhibitors of renal dipeptidase. aminophosphinic acid 28-48 dipeptidase 1 Homo sapiens 78-95 15618321-6 2005 The SV value increased until 78.0 +/- 9.3% of the power associated with maximal O(2) uptake (Vo(2 max)) in the HRDP group, whereas it increased until 94.4 +/- 8.6% of the power associated with Vo(2 max) in six other subjects (no-HRDP group, P = 0.004). o(2) 80-84 dipeptidase 1 Homo sapiens 111-115 15722906-5 2005 Three hours after intravenous injection of (99m)Tc-methylene diphosphonate ((99m)Tc-MDP), whole-body bone scans in the anterior and posterior projections were acquired. tc-methylene diphosphonate 48-74 dipeptidase 1 Homo sapiens 84-87 15177467-3 2004 Compounds 3a and 3c in which the phenyl ring was para substituted with F and Br and olefin with Z geometry, showed better inhibitory activity against RDP enzyme (IC50 = 5-6 nM). Alkenes 84-90 dipeptidase 1 Homo sapiens 150-153 12719943-3 2003 We wish to report the appearance of the isotope bone scan, technetium 99m-labeled methylene diphosphonate ((99m)Tc-MDP), associated with an auto-transplanted osteoarticular plug (epiphyseal transplant) performed following limb amputation. Technetium 59-73 dipeptidase 1 Homo sapiens 115-118 14679402-3 2003 We have designed a new method of administering N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) for experimental induction of moyamoya disease using an intravascular interventional technique combined with rod-shaped embolic materials made from lactic acid-glycolic acid copolymer. Acetylmuramyl-Alanyl-Isoglutamine 47-86 dipeptidase 1 Homo sapiens 88-91 14679402-3 2003 We have designed a new method of administering N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) for experimental induction of moyamoya disease using an intravascular interventional technique combined with rod-shaped embolic materials made from lactic acid-glycolic acid copolymer. Lactic Acid 241-252 dipeptidase 1 Homo sapiens 88-91 14679402-3 2003 We have designed a new method of administering N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) for experimental induction of moyamoya disease using an intravascular interventional technique combined with rod-shaped embolic materials made from lactic acid-glycolic acid copolymer. glycolic acid copolymer 253-276 dipeptidase 1 Homo sapiens 88-91 12719943-3 2003 We wish to report the appearance of the isotope bone scan, technetium 99m-labeled methylene diphosphonate ((99m)Tc-MDP), associated with an auto-transplanted osteoarticular plug (epiphyseal transplant) performed following limb amputation. methylene diphosphonate 82-105 dipeptidase 1 Homo sapiens 115-118 14584966-4 2003 It possesses higher stability than imipenem or meropenem against animal dehydropeptidase I. Imipenem 35-43 dipeptidase 1 Homo sapiens 72-90 14584966-4 2003 It possesses higher stability than imipenem or meropenem against animal dehydropeptidase I. Meropenem 47-56 dipeptidase 1 Homo sapiens 72-90 11796382-0 2002 Stability of new carbapenem DA-1131 to renal dipeptidase (dehydropeptidase I). Carbapenems 17-27 dipeptidase 1 Homo sapiens 39-56 12144777-0 2002 Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis. beta-Lactams 57-68 dipeptidase 1 Homo sapiens 27-44 12144777-1 2002 Human renal dipeptidase is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. Dipeptides 69-79 dipeptidase 1 Homo sapiens 6-23 12144777-1 2002 Human renal dipeptidase is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. Meropenem 124-129 dipeptidase 1 Homo sapiens 6-23 12144777-1 2002 Human renal dipeptidase is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. Carbapenems 134-144 dipeptidase 1 Homo sapiens 6-23 12144777-1 2002 Human renal dipeptidase is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. beta-Lactams 145-156 dipeptidase 1 Homo sapiens 6-23 12190122-5 2002 The MDP-induced cytotoxicity was characterized as apoptosis by DAPI staining and DNA laddering. DAPI 63-67 dipeptidase 1 Homo sapiens 4-7 12190122-6 2002 The acute rabbit kidney (RK13) cell apoptosis (cell death in < 5 h) induced by apical or basal application of MDP was associated with glutamate (Glu) release, decreased gamma-glutamyltranspeptidase (GGT) and acidosis and was suppressed by Indomethacin, Naproxen and Curcumin. Glutamic Acid 137-146 dipeptidase 1 Homo sapiens 113-116 12190122-6 2002 The acute rabbit kidney (RK13) cell apoptosis (cell death in < 5 h) induced by apical or basal application of MDP was associated with glutamate (Glu) release, decreased gamma-glutamyltranspeptidase (GGT) and acidosis and was suppressed by Indomethacin, Naproxen and Curcumin. Glutamic Acid 148-151 dipeptidase 1 Homo sapiens 113-116 12190122-6 2002 The acute rabbit kidney (RK13) cell apoptosis (cell death in < 5 h) induced by apical or basal application of MDP was associated with glutamate (Glu) release, decreased gamma-glutamyltranspeptidase (GGT) and acidosis and was suppressed by Indomethacin, Naproxen and Curcumin. Indomethacin 242-254 dipeptidase 1 Homo sapiens 113-116 12190122-6 2002 The acute rabbit kidney (RK13) cell apoptosis (cell death in < 5 h) induced by apical or basal application of MDP was associated with glutamate (Glu) release, decreased gamma-glutamyltranspeptidase (GGT) and acidosis and was suppressed by Indomethacin, Naproxen and Curcumin. Naproxen 256-264 dipeptidase 1 Homo sapiens 113-116 12190122-6 2002 The acute rabbit kidney (RK13) cell apoptosis (cell death in < 5 h) induced by apical or basal application of MDP was associated with glutamate (Glu) release, decreased gamma-glutamyltranspeptidase (GGT) and acidosis and was suppressed by Indomethacin, Naproxen and Curcumin. Curcumin 269-277 dipeptidase 1 Homo sapiens 113-116 12190122-9 2002 The results indicate that minute amounts (5 ng/ml) of MDP containing L-alanyl-D-isoglutamine can induce renal cell apoptosis in vitro and support MDP-induced kidney cytotoxicity in rabbits. l-alanyl-d-isoglutamine 69-92 dipeptidase 1 Homo sapiens 54-57 12190122-9 2002 The results indicate that minute amounts (5 ng/ml) of MDP containing L-alanyl-D-isoglutamine can induce renal cell apoptosis in vitro and support MDP-induced kidney cytotoxicity in rabbits. l-alanyl-d-isoglutamine 69-92 dipeptidase 1 Homo sapiens 146-149 11988094-2 2002 In this study the role of NO in the shedding of the glycosylphosphatidylinositol (GPI)-anchored form of renal dipeptidase (RDPase) was examined. Glycosylphosphatidylinositols 52-80 dipeptidase 1 Homo sapiens 104-121 11988094-2 2002 In this study the role of NO in the shedding of the glycosylphosphatidylinositol (GPI)-anchored form of renal dipeptidase (RDPase) was examined. Glycosylphosphatidylinositols 52-80 dipeptidase 1 Homo sapiens 123-129 11988094-2 2002 In this study the role of NO in the shedding of the glycosylphosphatidylinositol (GPI)-anchored form of renal dipeptidase (RDPase) was examined. Glycosylphosphatidylinositols 82-85 dipeptidase 1 Homo sapiens 104-121 11988094-2 2002 In this study the role of NO in the shedding of the glycosylphosphatidylinositol (GPI)-anchored form of renal dipeptidase (RDPase) was examined. Glycosylphosphatidylinositols 82-85 dipeptidase 1 Homo sapiens 123-129 11988094-3 2002 The NO donors sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine rapidly inhibited the release of RDPase from porcine kidney proximal tubules. Nitroprusside 14-34 dipeptidase 1 Homo sapiens 110-116 11988094-3 2002 The NO donors sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine rapidly inhibited the release of RDPase from porcine kidney proximal tubules. S-Nitroso-N-Acetylpenicillamine 45-76 dipeptidase 1 Homo sapiens 110-116 11988094-4 2002 The substrate of NO synthase, l-Arg, also inhibited the release of RDPase, and this effect was reversed by the NO synthase inhibitor N(omega)-nitro-l-arginine methyl ester. Arginine 30-35 dipeptidase 1 Homo sapiens 67-73 11988094-4 2002 The substrate of NO synthase, l-Arg, also inhibited the release of RDPase, and this effect was reversed by the NO synthase inhibitor N(omega)-nitro-l-arginine methyl ester. NG-Nitroarginine Methyl Ester 133-171 dipeptidase 1 Homo sapiens 67-73 11988094-5 2002 Western-blot analyses using antibodies raised against porcine RDPase and the inositol-1,2-cyclic monophosphate moiety formed on phospholipase C cleavage of the GPI anchor demonstrated that SNP mediated its inhibitory effect on the release of RDPase via a GPI-specific phospholipase C (GPI-PLC). inositol-1,2-cyclic monophosphate 77-110 dipeptidase 1 Homo sapiens 242-248 11796382-0 2002 Stability of new carbapenem DA-1131 to renal dipeptidase (dehydropeptidase I). Carbapenems 17-27 dipeptidase 1 Homo sapiens 58-76 11796382-0 2002 Stability of new carbapenem DA-1131 to renal dipeptidase (dehydropeptidase I). DA 1131 28-35 dipeptidase 1 Homo sapiens 39-56 11796382-0 2002 Stability of new carbapenem DA-1131 to renal dipeptidase (dehydropeptidase I). DA 1131 28-35 dipeptidase 1 Homo sapiens 58-76 11796382-1 2002 The stability of DA-1131 to renal dipeptidase (RDPase) (EC 3.4.13.19) was compared with that of imipenem and meropenem by V(max)/K(m) ratios as an index of the enzyme"s preference for substrates. DA 1131 17-24 dipeptidase 1 Homo sapiens 28-45 11796382-1 2002 The stability of DA-1131 to renal dipeptidase (RDPase) (EC 3.4.13.19) was compared with that of imipenem and meropenem by V(max)/K(m) ratios as an index of the enzyme"s preference for substrates. DA 1131 17-24 dipeptidase 1 Homo sapiens 47-53 11796382-3 2002 The biochemical evaluation of DA-1131 as the least preferred substrate of RDPase suggests its potential use as a novel beta-lactam antibiotic which may be usable without coadministration of RDPase inhibitors once its clinical suitability is proven. DA 1131 30-37 dipeptidase 1 Homo sapiens 74-80 11796382-3 2002 The biochemical evaluation of DA-1131 as the least preferred substrate of RDPase suggests its potential use as a novel beta-lactam antibiotic which may be usable without coadministration of RDPase inhibitors once its clinical suitability is proven. DA 1131 30-37 dipeptidase 1 Homo sapiens 190-196 11796382-3 2002 The biochemical evaluation of DA-1131 as the least preferred substrate of RDPase suggests its potential use as a novel beta-lactam antibiotic which may be usable without coadministration of RDPase inhibitors once its clinical suitability is proven. beta-Lactams 119-130 dipeptidase 1 Homo sapiens 74-80 10936509-1 2000 Endotoxin (lipopolysaccharide (LPS), 100 ng/ml) and muramyl dipeptide (MDP 100 ng/ml), two immunomodulatory bacterial cell wall products, were incubated with human whole blood, and the expression of receptors involved in antigen presentation, costimulation, and cell activation was investigated by use of flow cytometry. Acetylmuramyl-Alanyl-Isoglutamine 52-69 dipeptidase 1 Homo sapiens 71-74 11485566-4 2001 The site of cleavage in MDP-STM(ACE) was identified by MS as the Arg(374)-Ser(375) bond, corresponding to the Arg(1203)-Ser(1204) secretase cleavage site in somatic ACE. Arginine 65-68 dipeptidase 1 Homo sapiens 24-27 11485566-4 2001 The site of cleavage in MDP-STM(ACE) was identified by MS as the Arg(374)-Ser(375) bond, corresponding to the Arg(1203)-Ser(1204) secretase cleavage site in somatic ACE. Serine 74-77 dipeptidase 1 Homo sapiens 24-27 11485566-4 2001 The site of cleavage in MDP-STM(ACE) was identified by MS as the Arg(374)-Ser(375) bond, corresponding to the Arg(1203)-Ser(1204) secretase cleavage site in somatic ACE. Arginine 110-113 dipeptidase 1 Homo sapiens 24-27 11485566-4 2001 The site of cleavage in MDP-STM(ACE) was identified by MS as the Arg(374)-Ser(375) bond, corresponding to the Arg(1203)-Ser(1204) secretase cleavage site in somatic ACE. Serine 120-123 dipeptidase 1 Homo sapiens 24-27 11485566-5 2001 The release of MDP-STM(ACE) and ACE from the cells was inhibited in an identical manner by batimastat and two other hydroxamic acid-based zinc metallosecretase inhibitors. batimastat 91-101 dipeptidase 1 Homo sapiens 15-18 11464348-11 2001 Morphine consumption at 2, 6, and 24 hours was lower in the MDP and MD groups compared with the MP and M groups (P <.05). Morphine 0-8 dipeptidase 1 Homo sapiens 60-63 11464348-12 2001 The morphine-sparing effect was higher in groups MDP and MD compared with group MP (57% and 46%, respectively, v 8.2%, P <.05). Morphine 4-12 dipeptidase 1 Homo sapiens 49-52 11834871-0 2002 Glycosyl-phosphatidylinositol (GPI)-anchored renal dipeptidase is released by a phospholipase C in vivo. Glycosylphosphatidylinositols 0-29 dipeptidase 1 Homo sapiens 45-62 11834871-0 2002 Glycosyl-phosphatidylinositol (GPI)-anchored renal dipeptidase is released by a phospholipase C in vivo. Glycosylphosphatidylinositols 31-34 dipeptidase 1 Homo sapiens 45-62 11834871-3 2002 Western blot analysis of human and porcine purified dipeptidase and the urine concentrates with anti-(cross-reacting determinant) serum demonstrated the presence of inositol 1,2-cyclic monophosphate indicating that the renal dipeptidase had been released from the membrane by the action of a phospholipase C. This is the first direct evidence for cleavage of a human GPI-anchored protein by a responsible phospholipase C in vivo. inositol 1,2-cyclic monophosphate 165-198 dipeptidase 1 Homo sapiens 219-236 10727599-3 2000 Patients with a positive bone scan using technetium 99m methylene diphosphonate ((99m)Tc MDP) are eligible for treatment, and indications and contraindications for use are now well defined. methylene diphosphonate 56-79 dipeptidase 1 Homo sapiens 89-92 10727599-3 2000 Patients with a positive bone scan using technetium 99m methylene diphosphonate ((99m)Tc MDP) are eligible for treatment, and indications and contraindications for use are now well defined. Technetium 86-88 dipeptidase 1 Homo sapiens 89-92 9591596-0 1998 Extraskeletal uptake of technetium-99m-MDP in sites of heparin administration. Heparin 55-62 dipeptidase 1 Homo sapiens 39-42 10502626-1 1999 N-(7-Oxoacyl)-L-alanyl-D-isoglutamines are substances with similar effects on immune system as N-acetylmuramyldipeptide (MDP). n-(7-oxoacyl)-l-alanyl-d-isoglutamines 0-38 dipeptidase 1 Homo sapiens 121-124 10370741-5 1999 The mean renal dipeptidase activities in urine were 2.56, 2.46 and 0.78 U/mol creatinine for healthy subjects, patients with diabetes and patients with chronic renal failure, respectively. Creatinine 78-88 dipeptidase 1 Homo sapiens 9-26 9410073-4 1997 Meropenem is a parenteral carbapenem antibiotic stable to renal dehydropeptidase-I which has excellent bactericidal activity against almost all clinically significant aerobic and anaerobic organisms. Meropenem 0-9 dipeptidase 1 Homo sapiens 64-82 9712380-5 1998 Tc-99m MDP bone imaging showed a significant regression of osseous metastases. Technetium 0-3 dipeptidase 1 Homo sapiens 7-10 9453453-1 1997 Amphipathic and hydrophilic forms of human renal dipeptidase and urinary dipeptidase were purified by affinity chromatography using cilastatin, a dipeptidase inhibitor, as the ligand. Cilastatin 132-142 dipeptidase 1 Homo sapiens 43-60 9207914-3 1997 We have found that some derivatives having an amide group in the C-2 side chain show potent and well balanced antibacterial activities as well as high stability against dehydropeptidase-I. Amides 46-51 dipeptidase 1 Homo sapiens 169-187 8899192-2 1996 Cilastatin, an inhibitor of the tubular brush border enzyme dehydropeptidase-I, is added in a fixed combination to imipenem. Cilastatin 0-10 dipeptidase 1 Homo sapiens 60-78 8929386-1 1996 Diffuse pulmonary uptake of both technetium-99m- labeled methylene diphosphonate (99(m)Tc-MDP) and gallium (67Ga) citrate was noted in a patient with chronic renal failure and indicated the presence of pulmonary calcinosis. Technetium 33-47 dipeptidase 1 Homo sapiens 90-93 8929386-1 1996 Diffuse pulmonary uptake of both technetium-99m- labeled methylene diphosphonate (99(m)Tc-MDP) and gallium (67Ga) citrate was noted in a patient with chronic renal failure and indicated the presence of pulmonary calcinosis. methylene diphosphonate 57-80 dipeptidase 1 Homo sapiens 90-93 11725074-2 1995 Cs(+) (2 mM) inconsistently increased and then decreased the maximum diastolic potential (MDP); and markedly decreased diastolic depolarization (DD). Cesium 0-5 dipeptidase 1 Homo sapiens 90-93 8776942-3 1996 For many years the only notable success from such intensive research was the combination of imipenem with cilastatin, an inhibitor of the renal dipeptidase enzyme DHP-1. Imipenem 92-100 dipeptidase 1 Homo sapiens 138-155 8776942-3 1996 For many years the only notable success from such intensive research was the combination of imipenem with cilastatin, an inhibitor of the renal dipeptidase enzyme DHP-1. Cilastatin 106-116 dipeptidase 1 Homo sapiens 138-155 8776942-3 1996 For many years the only notable success from such intensive research was the combination of imipenem with cilastatin, an inhibitor of the renal dipeptidase enzyme DHP-1. dhp-1 163-168 dipeptidase 1 Homo sapiens 138-155 8797196-0 1996 Role of endogenous morphine in the attenuation of opiate withdrawal syndrome by N-acetylmuramyl-L-alanine-D-isoglutamine (MDP). Morphine 19-27 dipeptidase 1 Homo sapiens 122-125 8797196-0 1996 Role of endogenous morphine in the attenuation of opiate withdrawal syndrome by N-acetylmuramyl-L-alanine-D-isoglutamine (MDP). n-acetylmuramyl-l-alanine-d-isoglutamine 80-120 dipeptidase 1 Homo sapiens 122-125 8797196-4 1996 The present report shows that N-acetylmuramyl-L-alanine-D-isoglutamine (MDP), which elevates the endogenous opiate alkaloids in various brain regions and peripheral tissues, can attenuate the withdrawal syndrome of morphine-addicted rats. n-acetylmuramyl-l-alanine-d-isoglutamine 30-70 dipeptidase 1 Homo sapiens 72-75 8797196-4 1996 The present report shows that N-acetylmuramyl-L-alanine-D-isoglutamine (MDP), which elevates the endogenous opiate alkaloids in various brain regions and peripheral tissues, can attenuate the withdrawal syndrome of morphine-addicted rats. Opiate Alkaloids 108-114 dipeptidase 1 Homo sapiens 72-75 8797196-4 1996 The present report shows that N-acetylmuramyl-L-alanine-D-isoglutamine (MDP), which elevates the endogenous opiate alkaloids in various brain regions and peripheral tissues, can attenuate the withdrawal syndrome of morphine-addicted rats. Alkaloids 115-124 dipeptidase 1 Homo sapiens 72-75 8797196-4 1996 The present report shows that N-acetylmuramyl-L-alanine-D-isoglutamine (MDP), which elevates the endogenous opiate alkaloids in various brain regions and peripheral tissues, can attenuate the withdrawal syndrome of morphine-addicted rats. Morphine 215-223 dipeptidase 1 Homo sapiens 72-75 8737157-0 1996 Comparative stability of carbapenem and penem antibiotics to human recombinant dehydropeptidase-I. Carbapenems 25-35 dipeptidase 1 Homo sapiens 79-97 8737157-0 1996 Comparative stability of carbapenem and penem antibiotics to human recombinant dehydropeptidase-I. penem antibiotics 40-57 dipeptidase 1 Homo sapiens 79-97 11725074-8 1995 In 7 and 10 mM [K(+)](o), Cs(+) caused a small inconsistent hyperpolarization and a net depolarization in quiescent fibers; and decreased MDP in driven fibers. Cesium 26-31 dipeptidase 1 Homo sapiens 138-141 7605328-4 1995 Widespread areas of increased radionuclide uptake, consistent with skeletal metastases, were detected on 99mTc MDP bone imaging performed two days later. Radioisotopes 30-42 dipeptidase 1 Homo sapiens 111-114 7492120-0 1995 The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA. Cilastatin 63-73 dipeptidase 1 Homo sapiens 32-50 8574929-1 1995 Meropenem is a new carbapenem antibiotic that is stable to human renal dehydropeptidase-I (DHP-I) and exhibits potent bactericidal activity against almost all clinically significant aerobic and anaerobic bacteria. Meropenem 0-9 dipeptidase 1 Homo sapiens 91-96 8574929-1 1995 Meropenem is a new carbapenem antibiotic that is stable to human renal dehydropeptidase-I (DHP-I) and exhibits potent bactericidal activity against almost all clinically significant aerobic and anaerobic bacteria. Carbapenems 19-29 dipeptidase 1 Homo sapiens 91-96 7957346-2 1994 In group A (n = 30), following intravenous administration of 20 mCi (740 MBq) of technetium-99m methylene diphosphonate (99mTc-MDP), 3- and 24-h scintigraphy of bone lesions was performed. technetium-99m methylene diphosphonate 81-119 dipeptidase 1 Homo sapiens 127-130 7648757-2 1995 In comparison with imipenem, meropenem is relatively stable to hydrolysis by the enzyme dehydropeptidase I (DHP-I), thus precluding the need for coadministration with an inhibitor of DHP-I, such as cilastatin. Imipenem 19-27 dipeptidase 1 Homo sapiens 88-106 7648757-2 1995 In comparison with imipenem, meropenem is relatively stable to hydrolysis by the enzyme dehydropeptidase I (DHP-I), thus precluding the need for coadministration with an inhibitor of DHP-I, such as cilastatin. Meropenem 29-38 dipeptidase 1 Homo sapiens 88-106 7648757-2 1995 In comparison with imipenem, meropenem is relatively stable to hydrolysis by the enzyme dehydropeptidase I (DHP-I), thus precluding the need for coadministration with an inhibitor of DHP-I, such as cilastatin. Meropenem 29-38 dipeptidase 1 Homo sapiens 108-113 7648757-2 1995 In comparison with imipenem, meropenem is relatively stable to hydrolysis by the enzyme dehydropeptidase I (DHP-I), thus precluding the need for coadministration with an inhibitor of DHP-I, such as cilastatin. Meropenem 29-38 dipeptidase 1 Homo sapiens 183-188 7648757-2 1995 In comparison with imipenem, meropenem is relatively stable to hydrolysis by the enzyme dehydropeptidase I (DHP-I), thus precluding the need for coadministration with an inhibitor of DHP-I, such as cilastatin. Cilastatin 198-208 dipeptidase 1 Homo sapiens 88-106 7648757-2 1995 In comparison with imipenem, meropenem is relatively stable to hydrolysis by the enzyme dehydropeptidase I (DHP-I), thus precluding the need for coadministration with an inhibitor of DHP-I, such as cilastatin. Cilastatin 198-208 dipeptidase 1 Homo sapiens 108-113 7648757-2 1995 In comparison with imipenem, meropenem is relatively stable to hydrolysis by the enzyme dehydropeptidase I (DHP-I), thus precluding the need for coadministration with an inhibitor of DHP-I, such as cilastatin. Cilastatin 198-208 dipeptidase 1 Homo sapiens 183-188 7652497-1 1995 Meropenem is a new carbapenem antibiotic which differs chemically from imipenem/cilastatin by having a 1-beta-methyl substitution, providing it with excellent intrinsic stability to human renal dehydropeptidase-I. Meropenem 0-9 dipeptidase 1 Homo sapiens 194-212 7652504-2 1995 Meropenem is relatively stable to human renal dehydropeptidase-I (DHP-I); it does not require to be co-administered with cilastatin and consequently, unlike imipenem, will be administered as a single agent. Meropenem 0-9 dipeptidase 1 Homo sapiens 66-71 8004875-0 1994 Extraskeletal localization of MDP in soft tissue secondary to methotrexate infiltration. Methotrexate 62-74 dipeptidase 1 Homo sapiens 30-33 8405175-4 1993 Muramyl dipeptide, MDP, is a synthetic monomer of Gram positive and Gram negative bacterial cell walls. Acetylmuramyl-Alanyl-Isoglutamine 0-17 dipeptidase 1 Homo sapiens 19-22 8355083-0 1993 Uptake of technetium-99m MDP in primary amyloidosis with a review of the mechanisms of soft tissue localization of bone seeking radiopharmaceuticals. Technetium-99 10-23 dipeptidase 1 Homo sapiens 25-28 8514637-3 1993 The structure of the primary metabolite of meropenem by dehydropeptidase-I was shown to be the beta-lactam ring-opened product by comparing the spectroscopic data with those of meropenem, and confirmed by the preparation and structural analysis of its crystalline derivative. Meropenem 43-52 dipeptidase 1 Homo sapiens 56-74 8514637-3 1993 The structure of the primary metabolite of meropenem by dehydropeptidase-I was shown to be the beta-lactam ring-opened product by comparing the spectroscopic data with those of meropenem, and confirmed by the preparation and structural analysis of its crystalline derivative. beta-Lactams 95-106 dipeptidase 1 Homo sapiens 56-74 8514637-3 1993 The structure of the primary metabolite of meropenem by dehydropeptidase-I was shown to be the beta-lactam ring-opened product by comparing the spectroscopic data with those of meropenem, and confirmed by the preparation and structural analysis of its crystalline derivative. Meropenem 177-186 dipeptidase 1 Homo sapiens 56-74 8097406-0 1993 Importance of Glu-125 in the catalytic activity of human renal dipeptidase. Glutamic Acid 14-17 dipeptidase 1 Homo sapiens 57-74 8097406-1 1993 The carboxyl reagent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) and dansyl-ethylenediamine have shown to inhibit human renal dipeptidase (hrDP) irreversibly in a time-dependent manner. EEDQ 21-67 dipeptidase 1 Homo sapiens 130-147 8097406-1 1993 The carboxyl reagent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) and dansyl-ethylenediamine have shown to inhibit human renal dipeptidase (hrDP) irreversibly in a time-dependent manner. EEDQ 21-67 dipeptidase 1 Homo sapiens 149-153 8097406-1 1993 The carboxyl reagent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) and dansyl-ethylenediamine have shown to inhibit human renal dipeptidase (hrDP) irreversibly in a time-dependent manner. EEDQ 69-73 dipeptidase 1 Homo sapiens 130-147 8097406-1 1993 The carboxyl reagent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) and dansyl-ethylenediamine have shown to inhibit human renal dipeptidase (hrDP) irreversibly in a time-dependent manner. EEDQ 69-73 dipeptidase 1 Homo sapiens 149-153 8097406-1 1993 The carboxyl reagent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) and dansyl-ethylenediamine have shown to inhibit human renal dipeptidase (hrDP) irreversibly in a time-dependent manner. dansylethylenediamine 79-101 dipeptidase 1 Homo sapiens 130-147 8097406-1 1993 The carboxyl reagent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) and dansyl-ethylenediamine have shown to inhibit human renal dipeptidase (hrDP) irreversibly in a time-dependent manner. dansylethylenediamine 79-101 dipeptidase 1 Homo sapiens 149-153 8097406-4 1993 A comparison of the determined amino-acid sequences with the predicted primary structure of hrDP revealed that Glu-125 within the Glu115-Arg138 fragment was modified. Glutamic Acid 111-114 dipeptidase 1 Homo sapiens 92-96 8097406-8 1993 The mutated enzyme, Gln-125-hrDP exhibited specific activity of 28.5 U/mg, corresponding to 11.4% of the wild-type. Glutamine 20-23 dipeptidase 1 Homo sapiens 28-32 8097406-9 1993 In contrast, Asp-125-hrDP and Cys-125hrDP were found to be inactive (< or = 0.1% of wild-type enzyme). Aspartic Acid 13-16 dipeptidase 1 Homo sapiens 21-25 8097406-9 1993 In contrast, Asp-125-hrDP and Cys-125hrDP were found to be inactive (< or = 0.1% of wild-type enzyme). Cysteine 30-33 dipeptidase 1 Homo sapiens 37-41 1301069-0 1992 Inactivation of new carbapenem antibiotics by dehydropeptidase-I from porcine and human renal cortex. Carbapenems 20-30 dipeptidase 1 Homo sapiens 46-64 8447852-1 1993 Comparison has been made on the stability of 4 carbapenems and 3 penems against porcine renal dehydropeptidase-I (DHP-I). Carbapenems 47-58 dipeptidase 1 Homo sapiens 114-119 8447852-4 1993 According to the comparison of the Vmax/Km ratios, the order of stability of the compounds to hydrolysis by renal DHP-I was as follows: DHM >> DHC > HHC > AHC > HTC > CHC > FAC. dihydrocodeine 149-152 dipeptidase 1 Homo sapiens 114-119 8447852-5 1993 From this result it is particularly noteworthy that DHM has extremely high stability against renal DHP-I. Dihydromorphine 52-55 dipeptidase 1 Homo sapiens 99-104 1424374-0 1992 Diffuse liver and splenic activity with Tc-99m MDP associated with iohexol injection. tc-99 40-45 dipeptidase 1 Homo sapiens 47-50 1424374-0 1992 Diffuse liver and splenic activity with Tc-99m MDP associated with iohexol injection. Iohexol 67-74 dipeptidase 1 Homo sapiens 47-50 1341273-5 1992 In addition, the probe may assist with determining adequate margins at definitive resection of tumours which accumulate technetium-99m MDP. Technetium 120-130 dipeptidase 1 Homo sapiens 135-138 1301069-2 1992 The order of stability to hydrolysis by renal DHP-I was: LJC 10,627 greater than meropenem greater than panipenem greater than imipenem. Meropenem 81-90 dipeptidase 1 Homo sapiens 46-51 1301069-2 1992 The order of stability to hydrolysis by renal DHP-I was: LJC 10,627 greater than meropenem greater than panipenem greater than imipenem. panipenem 104-113 dipeptidase 1 Homo sapiens 46-51 1301069-2 1992 The order of stability to hydrolysis by renal DHP-I was: LJC 10,627 greater than meropenem greater than panipenem greater than imipenem. Imipenem 127-135 dipeptidase 1 Homo sapiens 46-51 1500362-2 1992 The antibacterial activity, susceptibility to dehydropeptidase-I (DHP-I) enzyme and chemical stability of these new carbapenems are also reported. Carbapenems 116-127 dipeptidase 1 Homo sapiens 46-64 1500362-2 1992 The antibacterial activity, susceptibility to dehydropeptidase-I (DHP-I) enzyme and chemical stability of these new carbapenems are also reported. Carbapenems 116-127 dipeptidase 1 Homo sapiens 66-71 2168407-2 1990 When treated with phosphatidylinositol-specific phospholipase C, hrDP was released from renal membrane fractions. Phosphatidylinositols 18-38 dipeptidase 1 Homo sapiens 65-69 1605616-0 1992 Renal dehydropeptidase-I stability of LJC 10,627, a new carbapenem antibiotic. Carbapenems 56-66 dipeptidase 1 Homo sapiens 6-24 1544318-1 1992 Renal dipeptidase (DPEP1) or dehydropeptidase-I (E.C.3.4.13.11) is a kidney membrane enzyme which hydrolyzes a variety of dipeptides. Dipeptides 122-132 dipeptidase 1 Homo sapiens 0-17 1544318-1 1992 Renal dipeptidase (DPEP1) or dehydropeptidase-I (E.C.3.4.13.11) is a kidney membrane enzyme which hydrolyzes a variety of dipeptides. Dipeptides 122-132 dipeptidase 1 Homo sapiens 19-24 1544318-1 1992 Renal dipeptidase (DPEP1) or dehydropeptidase-I (E.C.3.4.13.11) is a kidney membrane enzyme which hydrolyzes a variety of dipeptides. Dipeptides 122-132 dipeptidase 1 Homo sapiens 29-47 1544318-2 1992 DPEP1 is implicated in the renal metabolism of glutathione and its conjugates and is also responsible for hydrolysis of beta-lactam antibiotics. Glutathione 47-58 dipeptidase 1 Homo sapiens 0-5 1544318-2 1992 DPEP1 is implicated in the renal metabolism of glutathione and its conjugates and is also responsible for hydrolysis of beta-lactam antibiotics. beta-Lactams 120-131 dipeptidase 1 Homo sapiens 0-5 1762088-6 1991 Because the protein binding of DP was not only concentration-dependent but also stereoselective (i.e., S-DP binds to protein more extensively than R-DP), unbound pharmacokinetic parameters were used for evaluating the kinetic behaviors of DP enantiomers. Disopyramide 31-33 dipeptidase 1 Homo sapiens 147-151 2054857-2 1991 The introduction of fluorine at C-8 of racemic PS-5 led to slight improvements of the antimicrobial activity and the stability to renal dehydropeptidase-I. Fluorine 20-28 dipeptidase 1 Homo sapiens 136-154 2054858-1 1991 With partially purified kidney dehydropeptidase-I (DHP-I) preparations, the hydrolysis kinetics of glycyldehydrophenylalanine (Gly-dPh) by DHP-I were found to be completely non-Michaelian, whereas those of PS-5 and imipenem were composed of at least two-phase reactions which were also observed using Bacillus cereus type II beta-lactamase. Glycyldehydrophenylalanine 99-125 dipeptidase 1 Homo sapiens 31-49 2054858-1 1991 With partially purified kidney dehydropeptidase-I (DHP-I) preparations, the hydrolysis kinetics of glycyldehydrophenylalanine (Gly-dPh) by DHP-I were found to be completely non-Michaelian, whereas those of PS-5 and imipenem were composed of at least two-phase reactions which were also observed using Bacillus cereus type II beta-lactamase. Glycyldehydrophenylalanine 99-125 dipeptidase 1 Homo sapiens 51-56 2054858-1 1991 With partially purified kidney dehydropeptidase-I (DHP-I) preparations, the hydrolysis kinetics of glycyldehydrophenylalanine (Gly-dPh) by DHP-I were found to be completely non-Michaelian, whereas those of PS-5 and imipenem were composed of at least two-phase reactions which were also observed using Bacillus cereus type II beta-lactamase. Glycyldehydrophenylalanine 99-125 dipeptidase 1 Homo sapiens 139-144 2054858-1 1991 With partially purified kidney dehydropeptidase-I (DHP-I) preparations, the hydrolysis kinetics of glycyldehydrophenylalanine (Gly-dPh) by DHP-I were found to be completely non-Michaelian, whereas those of PS-5 and imipenem were composed of at least two-phase reactions which were also observed using Bacillus cereus type II beta-lactamase. gly-dph 127-134 dipeptidase 1 Homo sapiens 31-49 2054858-1 1991 With partially purified kidney dehydropeptidase-I (DHP-I) preparations, the hydrolysis kinetics of glycyldehydrophenylalanine (Gly-dPh) by DHP-I were found to be completely non-Michaelian, whereas those of PS-5 and imipenem were composed of at least two-phase reactions which were also observed using Bacillus cereus type II beta-lactamase. gly-dph 127-134 dipeptidase 1 Homo sapiens 51-56 2054858-1 1991 With partially purified kidney dehydropeptidase-I (DHP-I) preparations, the hydrolysis kinetics of glycyldehydrophenylalanine (Gly-dPh) by DHP-I were found to be completely non-Michaelian, whereas those of PS-5 and imipenem were composed of at least two-phase reactions which were also observed using Bacillus cereus type II beta-lactamase. gly-dph 127-134 dipeptidase 1 Homo sapiens 139-144 2054858-1 1991 With partially purified kidney dehydropeptidase-I (DHP-I) preparations, the hydrolysis kinetics of glycyldehydrophenylalanine (Gly-dPh) by DHP-I were found to be completely non-Michaelian, whereas those of PS-5 and imipenem were composed of at least two-phase reactions which were also observed using Bacillus cereus type II beta-lactamase. Imipenem 215-223 dipeptidase 1 Homo sapiens 31-49 2054858-1 1991 With partially purified kidney dehydropeptidase-I (DHP-I) preparations, the hydrolysis kinetics of glycyldehydrophenylalanine (Gly-dPh) by DHP-I were found to be completely non-Michaelian, whereas those of PS-5 and imipenem were composed of at least two-phase reactions which were also observed using Bacillus cereus type II beta-lactamase. Imipenem 215-223 dipeptidase 1 Homo sapiens 51-56 2054858-1 1991 With partially purified kidney dehydropeptidase-I (DHP-I) preparations, the hydrolysis kinetics of glycyldehydrophenylalanine (Gly-dPh) by DHP-I were found to be completely non-Michaelian, whereas those of PS-5 and imipenem were composed of at least two-phase reactions which were also observed using Bacillus cereus type II beta-lactamase. Imipenem 215-223 dipeptidase 1 Homo sapiens 139-144 2054858-3 1991 The in vitro DHP-I stability of PS-5 was significantly improved by introduction of basic side chains and cysteines at C-3. Cysteine 105-114 dipeptidase 1 Homo sapiens 13-18 2083136-0 1990 Accumulation of technetium-99m MDP in pseudomyxoma peritonei. Technetium 16-26 dipeptidase 1 Homo sapiens 31-34 2168407-8 1990 These results suggest that the mature hrDP molecule lacks the carboxyl-terminal hydrophobic peptide extension predicted from the cDNA sequence and is anchored at Ser369 via glycosylphosphatidylinositol to the membrane. Glycosylphosphatidylinositols 173-201 dipeptidase 1 Homo sapiens 38-42 2137335-0 1990 Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme. Glycosylphosphatidylinositols 24-53 dipeptidase 1 Homo sapiens 69-86 2139939-4 1990 However, when the dehydropeptidase I inhibitor cilastatin is given concomitantly with imipenem the urinary excretion and clearance of imipenem reach similar values in all subjects; in addition, the antibiotic is better tolerated by the kidney. Imipenem 86-94 dipeptidase 1 Homo sapiens 18-36 2139939-4 1990 However, when the dehydropeptidase I inhibitor cilastatin is given concomitantly with imipenem the urinary excretion and clearance of imipenem reach similar values in all subjects; in addition, the antibiotic is better tolerated by the kidney. Imipenem 134-142 dipeptidase 1 Homo sapiens 18-36 2137335-4 1990 The glycosyl-phosphatidylinositol anchor of purified human renal dipeptidase was hydrolysed by a range of bacterial PI-PLCs and by a plasma phospholipase D. Mild acid treatment and nitrous acid deamination of the hydrophilic form revealed that the cross-reacting determinant, characteristic of the glycosyl-phosphatidylinositol anchor, was due exclusively to the inositol 1,2-cyclic phosphate ring epitope. Glycosylphosphatidylinositols 4-33 dipeptidase 1 Homo sapiens 59-76 2137335-4 1990 The glycosyl-phosphatidylinositol anchor of purified human renal dipeptidase was hydrolysed by a range of bacterial PI-PLCs and by a plasma phospholipase D. Mild acid treatment and nitrous acid deamination of the hydrophilic form revealed that the cross-reacting determinant, characteristic of the glycosyl-phosphatidylinositol anchor, was due exclusively to the inositol 1,2-cyclic phosphate ring epitope. Nitrous Acid 181-193 dipeptidase 1 Homo sapiens 59-76 2137335-4 1990 The glycosyl-phosphatidylinositol anchor of purified human renal dipeptidase was hydrolysed by a range of bacterial PI-PLCs and by a plasma phospholipase D. Mild acid treatment and nitrous acid deamination of the hydrophilic form revealed that the cross-reacting determinant, characteristic of the glycosyl-phosphatidylinositol anchor, was due exclusively to the inositol 1,2-cyclic phosphate ring epitope. Glycosylphosphatidylinositols 298-327 dipeptidase 1 Homo sapiens 59-76 2137335-4 1990 The glycosyl-phosphatidylinositol anchor of purified human renal dipeptidase was hydrolysed by a range of bacterial PI-PLCs and by a plasma phospholipase D. Mild acid treatment and nitrous acid deamination of the hydrophilic form revealed that the cross-reacting determinant, characteristic of the glycosyl-phosphatidylinositol anchor, was due exclusively to the inositol 1,2-cyclic phosphate ring epitope. inositol cyclic phosphate 363-392 dipeptidase 1 Homo sapiens 59-76 2137335-6 1990 The N-terminal sequence of human renal dipeptidase showed a high degree of similarity with that of the pig enzyme, and enzymic deglycosylation revealed that the difference in size of renal dipeptidase between these two species is due almost entirely to differences in the extent of N-linked glycosylation. Nitrogen 4-5 dipeptidase 1 Homo sapiens 33-50 34707639-4 2021 The ExWAS identified two loci, 1p36.22 (lead single-nucleotide polymorphism (SNP) rs1801133, MTHFR C677T) and 16q24.3 (rs1126464, DPEP1), showing exome-wide significant association with tHCY (p < 5E-7); and both loci have been previously associated with tHCY in non-East Asian populations. thcy 186-190 dipeptidase 1 Homo sapiens 130-135 2384103-2 1990 After injection of technetium methylene diphosphonate Tc 99m (99mTc-MDP) the count rate was recorded as serial images over the lower thoracic and all the lumbar vertebrae from 1 to 240 min post-injection. Technetium Tc 99m Medronate 19-53 dipeptidase 1 Homo sapiens 68-71 2139939-4 1990 However, when the dehydropeptidase I inhibitor cilastatin is given concomitantly with imipenem the urinary excretion and clearance of imipenem reach similar values in all subjects; in addition, the antibiotic is better tolerated by the kidney. Cilastatin 47-57 dipeptidase 1 Homo sapiens 18-36 2768222-1 1989 Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11] was solubilized from the membrane fraction of kidney by treatment with octyl-beta-D-glucoside and purified by a procedure including ion exchange chromatography and affinity chromatography on cilastatin-immobilized Sepharose. octyl-beta-D-glucoside 186-208 dipeptidase 1 Homo sapiens 6-28 35108055-0 2022 Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion. Dexamethasone 0-13 dipeptidase 1 Homo sapiens 75-88 35108055-4 2022 Mechanistically, we identified that dexamethasone up-regulated the GSH metabolism regulating protein dipeptidase-1 (DPEP1) in a glucocorticoid receptor (GR)-dependent manner. Dexamethasone 36-49 dipeptidase 1 Homo sapiens 101-114 35108055-4 2022 Mechanistically, we identified that dexamethasone up-regulated the GSH metabolism regulating protein dipeptidase-1 (DPEP1) in a glucocorticoid receptor (GR)-dependent manner. Dexamethasone 36-49 dipeptidase 1 Homo sapiens 116-121 35108055-4 2022 Mechanistically, we identified that dexamethasone up-regulated the GSH metabolism regulating protein dipeptidase-1 (DPEP1) in a glucocorticoid receptor (GR)-dependent manner. Glutathione 67-70 dipeptidase 1 Homo sapiens 101-114 35108055-4 2022 Mechanistically, we identified that dexamethasone up-regulated the GSH metabolism regulating protein dipeptidase-1 (DPEP1) in a glucocorticoid receptor (GR)-dependent manner. Glutathione 67-70 dipeptidase 1 Homo sapiens 116-121 35108055-5 2022 DPEP1 knockdown reversed the phenotype of dexamethasone-induced ferroptosis sensitization. Dexamethasone 42-55 dipeptidase 1 Homo sapiens 0-5 35108055-6 2022 Ferroptosis inhibitors, the DPEP1 inhibitor cilastatin, or genetic DPEP1 inactivation reversed the dexamethasone-induced increase in tubular necrosis in freshly isolated renal tubules. Cilastatin 44-54 dipeptidase 1 Homo sapiens 28-33 35108055-6 2022 Ferroptosis inhibitors, the DPEP1 inhibitor cilastatin, or genetic DPEP1 inactivation reversed the dexamethasone-induced increase in tubular necrosis in freshly isolated renal tubules. Dexamethasone 99-112 dipeptidase 1 Homo sapiens 28-33 35108055-6 2022 Ferroptosis inhibitors, the DPEP1 inhibitor cilastatin, or genetic DPEP1 inactivation reversed the dexamethasone-induced increase in tubular necrosis in freshly isolated renal tubules. Dexamethasone 99-112 dipeptidase 1 Homo sapiens 67-72 35108055-7 2022 Our data indicate that dexamethasone sensitizes to ferroptosis by a GR-mediated increase in DPEP1 expression and GSH depletion. Dexamethasone 23-36 dipeptidase 1 Homo sapiens 92-97 2768222-6 1989 We also examined the substrate specificity of human MDP and found that human MDP catalyzed the hydrolysis of S(substituent)-L-cysteinyl-glycine adducts such as L-cystinyl-bis(glycine) and S-N-ethylmaleimide-L-cysteinyl-glycine, as well as the conversion of leukotriene D4 to leukotriene E4. s-n-ethylmaleimide-l-cysteinyl-glycine 188-226 dipeptidase 1 Homo sapiens 52-55 2768222-6 1989 We also examined the substrate specificity of human MDP and found that human MDP catalyzed the hydrolysis of S(substituent)-L-cysteinyl-glycine adducts such as L-cystinyl-bis(glycine) and S-N-ethylmaleimide-L-cysteinyl-glycine, as well as the conversion of leukotriene D4 to leukotriene E4. s-n-ethylmaleimide-l-cysteinyl-glycine 188-226 dipeptidase 1 Homo sapiens 77-80 2768222-6 1989 We also examined the substrate specificity of human MDP and found that human MDP catalyzed the hydrolysis of S(substituent)-L-cysteinyl-glycine adducts such as L-cystinyl-bis(glycine) and S-N-ethylmaleimide-L-cysteinyl-glycine, as well as the conversion of leukotriene D4 to leukotriene E4. Leukotriene D4 257-271 dipeptidase 1 Homo sapiens 52-55 2768222-6 1989 We also examined the substrate specificity of human MDP and found that human MDP catalyzed the hydrolysis of S(substituent)-L-cysteinyl-glycine adducts such as L-cystinyl-bis(glycine) and S-N-ethylmaleimide-L-cysteinyl-glycine, as well as the conversion of leukotriene D4 to leukotriene E4. Leukotriene D4 257-271 dipeptidase 1 Homo sapiens 77-80 2768222-6 1989 We also examined the substrate specificity of human MDP and found that human MDP catalyzed the hydrolysis of S(substituent)-L-cysteinyl-glycine adducts such as L-cystinyl-bis(glycine) and S-N-ethylmaleimide-L-cysteinyl-glycine, as well as the conversion of leukotriene D4 to leukotriene E4. Leukotriene E4 275-289 dipeptidase 1 Homo sapiens 52-55 2768222-6 1989 We also examined the substrate specificity of human MDP and found that human MDP catalyzed the hydrolysis of S(substituent)-L-cysteinyl-glycine adducts such as L-cystinyl-bis(glycine) and S-N-ethylmaleimide-L-cysteinyl-glycine, as well as the conversion of leukotriene D4 to leukotriene E4. Leukotriene E4 275-289 dipeptidase 1 Homo sapiens 77-80 2768222-7 1989 These results suggest that MDP might play an important role in the metabolism of glutathione and leukotriene. Glutathione 81-92 dipeptidase 1 Homo sapiens 27-30 2768222-7 1989 These results suggest that MDP might play an important role in the metabolism of glutathione and leukotriene. Leukotrienes 97-108 dipeptidase 1 Homo sapiens 27-30 2605853-0 1989 Soft tissue uptake on Tc-99m MDP bone scan after cardioversion. tc-99 22-27 dipeptidase 1 Homo sapiens 29-32 2816414-1 1989 The changes of heart rate (HR) and dP/dtmax elicited by challenging the sensitized heart and by a bolus injection of histamine in the presence of cimetidine were observed. Histamine 117-126 dipeptidase 1 Homo sapiens 15-37 2768222-1 1989 Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11] was solubilized from the membrane fraction of kidney by treatment with octyl-beta-D-glucoside and purified by a procedure including ion exchange chromatography and affinity chromatography on cilastatin-immobilized Sepharose. octyl-beta-D-glucoside 186-208 dipeptidase 1 Homo sapiens 30-33 2768222-1 1989 Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11] was solubilized from the membrane fraction of kidney by treatment with octyl-beta-D-glucoside and purified by a procedure including ion exchange chromatography and affinity chromatography on cilastatin-immobilized Sepharose. octyl-beta-D-glucoside 186-208 dipeptidase 1 Homo sapiens 59-77 2768222-1 1989 Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11] was solubilized from the membrane fraction of kidney by treatment with octyl-beta-D-glucoside and purified by a procedure including ion exchange chromatography and affinity chromatography on cilastatin-immobilized Sepharose. octyl-beta-D-glucoside 186-208 dipeptidase 1 Homo sapiens 81-98 2768222-1 1989 Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11] was solubilized from the membrane fraction of kidney by treatment with octyl-beta-D-glucoside and purified by a procedure including ion exchange chromatography and affinity chromatography on cilastatin-immobilized Sepharose. Cilastatin 306-316 dipeptidase 1 Homo sapiens 6-28 2768222-1 1989 Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11] was solubilized from the membrane fraction of kidney by treatment with octyl-beta-D-glucoside and purified by a procedure including ion exchange chromatography and affinity chromatography on cilastatin-immobilized Sepharose. Cilastatin 306-316 dipeptidase 1 Homo sapiens 30-33 2768222-1 1989 Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11] was solubilized from the membrane fraction of kidney by treatment with octyl-beta-D-glucoside and purified by a procedure including ion exchange chromatography and affinity chromatography on cilastatin-immobilized Sepharose. Cilastatin 306-316 dipeptidase 1 Homo sapiens 59-77 2768222-1 1989 Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11] was solubilized from the membrane fraction of kidney by treatment with octyl-beta-D-glucoside and purified by a procedure including ion exchange chromatography and affinity chromatography on cilastatin-immobilized Sepharose. Cilastatin 306-316 dipeptidase 1 Homo sapiens 81-98 2768222-1 1989 Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11] was solubilized from the membrane fraction of kidney by treatment with octyl-beta-D-glucoside and purified by a procedure including ion exchange chromatography and affinity chromatography on cilastatin-immobilized Sepharose. Sepharose 329-338 dipeptidase 1 Homo sapiens 6-28 2768222-1 1989 Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11] was solubilized from the membrane fraction of kidney by treatment with octyl-beta-D-glucoside and purified by a procedure including ion exchange chromatography and affinity chromatography on cilastatin-immobilized Sepharose. Sepharose 329-338 dipeptidase 1 Homo sapiens 30-33 2768222-1 1989 Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11] was solubilized from the membrane fraction of kidney by treatment with octyl-beta-D-glucoside and purified by a procedure including ion exchange chromatography and affinity chromatography on cilastatin-immobilized Sepharose. Sepharose 329-338 dipeptidase 1 Homo sapiens 59-77 2768222-1 1989 Human microsomal dipeptidase (MDP, formerly referred to as dehydropeptidase-I or renal dipeptidase) [EC 3.4.13.11] was solubilized from the membrane fraction of kidney by treatment with octyl-beta-D-glucoside and purified by a procedure including ion exchange chromatography and affinity chromatography on cilastatin-immobilized Sepharose. Sepharose 329-338 dipeptidase 1 Homo sapiens 81-98 2768222-2 1989 The purified human MDP was found to be homogeneous on sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis. Sodium Dodecyl Sulfate 54-76 dipeptidase 1 Homo sapiens 19-22 2768222-2 1989 The purified human MDP was found to be homogeneous on sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis. Sodium Dodecyl Sulfate 78-81 dipeptidase 1 Homo sapiens 19-22 2768222-2 1989 The purified human MDP was found to be homogeneous on sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis. polyacrylamide gels 83-101 dipeptidase 1 Homo sapiens 19-22 2768222-4 1989 After treatment with endoglycosidase F, human MDP showed a single band with an apparent Mr of 42 kDa on SDS-polyacrylamide gel electrophoresis. Sodium Dodecyl Sulfate 104-107 dipeptidase 1 Homo sapiens 46-49 2768222-4 1989 After treatment with endoglycosidase F, human MDP showed a single band with an apparent Mr of 42 kDa on SDS-polyacrylamide gel electrophoresis. polyacrylamide 108-122 dipeptidase 1 Homo sapiens 46-49 2768222-5 1989 Human MDP was found to bind to Con A-Sepharose and the activity was eluted with methyl-alpha-D-mannopyranoside, suggesting that human MDP is a glycoprotein. Sepharose 37-46 dipeptidase 1 Homo sapiens 6-9 2768222-5 1989 Human MDP was found to bind to Con A-Sepharose and the activity was eluted with methyl-alpha-D-mannopyranoside, suggesting that human MDP is a glycoprotein. Sepharose 37-46 dipeptidase 1 Homo sapiens 134-137 2768222-5 1989 Human MDP was found to bind to Con A-Sepharose and the activity was eluted with methyl-alpha-D-mannopyranoside, suggesting that human MDP is a glycoprotein. methylmannoside 80-110 dipeptidase 1 Homo sapiens 6-9 2768222-5 1989 Human MDP was found to bind to Con A-Sepharose and the activity was eluted with methyl-alpha-D-mannopyranoside, suggesting that human MDP is a glycoprotein. methylmannoside 80-110 dipeptidase 1 Homo sapiens 134-137 2768222-6 1989 We also examined the substrate specificity of human MDP and found that human MDP catalyzed the hydrolysis of S(substituent)-L-cysteinyl-glycine adducts such as L-cystinyl-bis(glycine) and S-N-ethylmaleimide-L-cysteinyl-glycine, as well as the conversion of leukotriene D4 to leukotriene E4. cysteinylglycine 122-143 dipeptidase 1 Homo sapiens 52-55 2535487-1 1989 Poly-L-lysine modified with mannose derivatives, the residual cationic charges of which being neutralized by N-acylation, were synthesized and used as carriers of a macrophage activator (N-acetylmuramyl dipeptide, MDP). Lysine 0-13 dipeptidase 1 Homo sapiens 214-217 2535487-1 1989 Poly-L-lysine modified with mannose derivatives, the residual cationic charges of which being neutralized by N-acylation, were synthesized and used as carriers of a macrophage activator (N-acetylmuramyl dipeptide, MDP). Mannose 28-35 dipeptidase 1 Homo sapiens 214-217 2768222-6 1989 We also examined the substrate specificity of human MDP and found that human MDP catalyzed the hydrolysis of S(substituent)-L-cysteinyl-glycine adducts such as L-cystinyl-bis(glycine) and S-N-ethylmaleimide-L-cysteinyl-glycine, as well as the conversion of leukotriene D4 to leukotriene E4. cysteinylglycine 122-143 dipeptidase 1 Homo sapiens 77-80 2768222-6 1989 We also examined the substrate specificity of human MDP and found that human MDP catalyzed the hydrolysis of S(substituent)-L-cysteinyl-glycine adducts such as L-cystinyl-bis(glycine) and S-N-ethylmaleimide-L-cysteinyl-glycine, as well as the conversion of leukotriene D4 to leukotriene E4. l-cystinyl-bis(glycine) 160-183 dipeptidase 1 Homo sapiens 52-55 2768222-6 1989 We also examined the substrate specificity of human MDP and found that human MDP catalyzed the hydrolysis of S(substituent)-L-cysteinyl-glycine adducts such as L-cystinyl-bis(glycine) and S-N-ethylmaleimide-L-cysteinyl-glycine, as well as the conversion of leukotriene D4 to leukotriene E4. l-cystinyl-bis(glycine) 160-183 dipeptidase 1 Homo sapiens 77-80 3383518-1 1988 SPECT was used to identify a focal accumulation of cardiac calcification using Tc-99m MDP in a patient with an arrhythmia and known metastatic calcification elsewhere. Technetium 79-85 dipeptidase 1 Homo sapiens 86-89 3168364-0 1988 Diffuse muscle uptake of technetium-99M MDP in a patient with lung cancer. Technetium-99 25-38 dipeptidase 1 Homo sapiens 40-43 2816414-1 1989 The changes of heart rate (HR) and dP/dtmax elicited by challenging the sensitized heart and by a bolus injection of histamine in the presence of cimetidine were observed. Cimetidine 146-156 dipeptidase 1 Homo sapiens 15-37 2844265-3 1988 A quantitative assay for renal dipeptidase was developed which measures the rate of release of glycine from glycylpeptides by pre-column derivatization of the amino acid with phenylisothiocyanate followed by high-performance liquid chromatography. Glycine 95-102 dipeptidase 1 Homo sapiens 25-42 2844265-3 1988 A quantitative assay for renal dipeptidase was developed which measures the rate of release of glycine from glycylpeptides by pre-column derivatization of the amino acid with phenylisothiocyanate followed by high-performance liquid chromatography. glycylpeptides 108-122 dipeptidase 1 Homo sapiens 25-42 2844265-3 1988 A quantitative assay for renal dipeptidase was developed which measures the rate of release of glycine from glycylpeptides by pre-column derivatization of the amino acid with phenylisothiocyanate followed by high-performance liquid chromatography. phenylisothiocyanate 175-195 dipeptidase 1 Homo sapiens 25-42 2844265-14 1988 The conversion of leukotriene D4 to leukotriene E4 in the presence of human renal dipeptidase was demonstrated by HPLC procedures. Leukotriene D4 18-32 dipeptidase 1 Homo sapiens 76-93 2844265-14 1988 The conversion of leukotriene D4 to leukotriene E4 in the presence of human renal dipeptidase was demonstrated by HPLC procedures. Leukotriene E4 36-50 dipeptidase 1 Homo sapiens 76-93 3527628-6 1986 MDP and its derivatives, such as murabutide, will also prove useful in combination with chemotherapy, especially for immunodepressed and elderly patients. murabutide 33-43 dipeptidase 1 Homo sapiens 0-3 3125614-0 1987 [Muramyl dipeptide (MDP): its origin, mechanism of action and prospects for its use]. Acetylmuramyl-Alanyl-Isoglutamine 1-18 dipeptidase 1 Homo sapiens 20-23 3331041-1 1987 Imipenem/cilastatin is the combination of a broad spectrum beta-lactam antibiotic with dehydropeptidase I--an inhibitor of the metabolism of imipenem. Imipenem 0-8 dipeptidase 1 Homo sapiens 87-105 3331041-1 1987 Imipenem/cilastatin is the combination of a broad spectrum beta-lactam antibiotic with dehydropeptidase I--an inhibitor of the metabolism of imipenem. Cilastatin 9-19 dipeptidase 1 Homo sapiens 87-105 3331041-1 1987 Imipenem/cilastatin is the combination of a broad spectrum beta-lactam antibiotic with dehydropeptidase I--an inhibitor of the metabolism of imipenem. Imipenem 141-149 dipeptidase 1 Homo sapiens 87-105 3546249-2 1986 Since it is hydrolysed by dehydropeptidase-I, a zinc metallo-enzyme resident in the brush border of the renal tubule, it is co-administered with cilastatin, a reversible inhibitor of this enzyme. Cilastatin 145-155 dipeptidase 1 Homo sapiens 26-44 3769329-0 1986 Myocardial, pulmonary, and gastric uptake of technetium-99m MDP in a patient with multiple myeloma and hypercalcemia. Technetium 45-59 dipeptidase 1 Homo sapiens 60-63 3742914-1 1986 Two cases of primary retroperitoneal benign teratoma, in which Tc-99m MDP localized in the primary tumor are presented. tc-99 63-68 dipeptidase 1 Homo sapiens 70-73 3464785-2 1986 Pharmacokinetic and clinical studies of imipenem/cilastatin sodium (MK-0787/MK-0791), a new carbapenem antibiotic and a dehydropeptidase-I inhibitor, respectively, were carried out in a joint study in the pediatric field by a study group consisting of investigators at 16 institutions. Imipenem 40-48 dipeptidase 1 Homo sapiens 120-138 3463788-1 1986 Imipenem/cilastatin sodium (MK-0787/MK-0791), a carbapenem antibiotic and a dehydropeptidase-I inhibitor, was administered at a dose of 500 mg/500 mg twice a day for 5 days for the treatment of obstetric and gynecologic infections. Imipenem 0-8 dipeptidase 1 Homo sapiens 76-94 3463788-1 1986 Imipenem/cilastatin sodium (MK-0787/MK-0791), a carbapenem antibiotic and a dehydropeptidase-I inhibitor, was administered at a dose of 500 mg/500 mg twice a day for 5 days for the treatment of obstetric and gynecologic infections. Cilastatin 9-26 dipeptidase 1 Homo sapiens 76-94 3956046-1 1986 Tc-99m MDP injected into a central venous catheter showed a pattern corresponding to the left pleural space. tc-99 0-5 dipeptidase 1 Homo sapiens 7-10 3713369-1 1986 MDP is a synthetic copy of part of the bacterial cell wall which has been shown to be the minimal structure capable of replacing Mycobacteria in Complete Freund Adjuvant. complete freund adjuvant 145-169 dipeptidase 1 Homo sapiens 0-3 3527818-3 1986 Muramyl peptides (MDP) are synthetic glycopeptides which can substitute mycobacteria in FCA and are also adjuvant-active in saline. Glycopeptides 37-50 dipeptidase 1 Homo sapiens 18-21 3527818-3 1986 Muramyl peptides (MDP) are synthetic glycopeptides which can substitute mycobacteria in FCA and are also adjuvant-active in saline. Sodium Chloride 124-130 dipeptidase 1 Homo sapiens 18-21 3480361-0 1987 [Effects of cilastatin sodium, an inhibitor of dehydropeptidase-I, on human urinary peptide excretion. Cilastatin 12-29 dipeptidase 1 Homo sapiens 47-65 3480361-9 1987 From the above results, CS, as a dehydropeptidase-I inhibitor apparently caused increases in some peptides consisting mainly of Asp, Glu, Gly and Ala in patients with impaired renal function. Cesium 24-26 dipeptidase 1 Homo sapiens 33-51 3480361-9 1987 From the above results, CS, as a dehydropeptidase-I inhibitor apparently caused increases in some peptides consisting mainly of Asp, Glu, Gly and Ala in patients with impaired renal function. Aspartic Acid 128-131 dipeptidase 1 Homo sapiens 33-51 3480361-9 1987 From the above results, CS, as a dehydropeptidase-I inhibitor apparently caused increases in some peptides consisting mainly of Asp, Glu, Gly and Ala in patients with impaired renal function. Glutamic Acid 133-136 dipeptidase 1 Homo sapiens 33-51 3480361-9 1987 From the above results, CS, as a dehydropeptidase-I inhibitor apparently caused increases in some peptides consisting mainly of Asp, Glu, Gly and Ala in patients with impaired renal function. Glycine 138-141 dipeptidase 1 Homo sapiens 33-51 3480361-9 1987 From the above results, CS, as a dehydropeptidase-I inhibitor apparently caused increases in some peptides consisting mainly of Asp, Glu, Gly and Ala in patients with impaired renal function. Alanine 146-149 dipeptidase 1 Homo sapiens 33-51 3608331-2 1987 Radionuclide bone scanning with Tc-99m MDP is a sensitive indicator of early osseous metastases in breast cancer. tc-99 32-37 dipeptidase 1 Homo sapiens 39-42 3595029-1 1987 A case of a 12-year-old boy with sacroiliitis documented by positive Tc-99m MDP and Ga-67 scans is described. tc-99 69-74 dipeptidase 1 Homo sapiens 76-79 3495664-0 1987 Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids. (z)-2-(acylamino)-3-substituted-propenoic acids 85-132 dipeptidase 1 Homo sapiens 62-80 3581620-0 1987 Exercise-induced muscle uptake of technetium-99m MDP. Technetium-99 34-47 dipeptidase 1 Homo sapiens 49-52 3581620-1 1987 Intense muscle localization of Tc-99m MDP to upper extremity musculature was noted three days following weight lifting exercises. Technetium 31-37 dipeptidase 1 Homo sapiens 38-41 3597113-2 1987 The HSA-binding of 99mTc incubated as 99mTc(113Sn)-MDP depends in vitro on the presence of competing anions normally present in plasma and on the MDP and Tc concentration, but is independent of the Sn concentration. Technetium 22-24 dipeptidase 1 Homo sapiens 51-54 3597113-2 1987 The HSA-binding of 99mTc incubated as 99mTc(113Sn)-MDP depends in vitro on the presence of competing anions normally present in plasma and on the MDP and Tc concentration, but is independent of the Sn concentration. Technetium 22-24 dipeptidase 1 Homo sapiens 146-149 3597113-3 1987 The HSA-binding of 113Sn depends on the MDP and Sn concentration; not on the Tc concentration. Altretamine 4-7 dipeptidase 1 Homo sapiens 40-43 3597113-3 1987 The HSA-binding of 113Sn depends on the MDP and Sn concentration; not on the Tc concentration. Tin-113 19-24 dipeptidase 1 Homo sapiens 40-43 3597113-3 1987 The HSA-binding of 113Sn depends on the MDP and Sn concentration; not on the Tc concentration. Tin 22-24 dipeptidase 1 Homo sapiens 40-43 3597113-4 1987 99mTc(Sn)-MDP binds to HSA as a unit. Altretamine 23-26 dipeptidase 1 Homo sapiens 10-13 3465739-1 1986 Cilastatin, a dehydropeptidase-I inhibitor, is coadministered with the beta-lactam antibiotic imipenem. Cilastatin 0-10 dipeptidase 1 Homo sapiens 14-32 3465739-1 1986 Cilastatin, a dehydropeptidase-I inhibitor, is coadministered with the beta-lactam antibiotic imipenem. Imipenem 94-102 dipeptidase 1 Homo sapiens 14-32 3527509-1 1986 Abnormal pulmonary uptake of Ga-67 citrate and Tc-99m MDP and reversible liver uptake of Tc-99m MDP was seen in a patient with hypercalcemia of lymphoma and biopsy-proven metastatic pulmonary calcification. tc-99 47-52 dipeptidase 1 Homo sapiens 54-57 3527509-1 1986 Abnormal pulmonary uptake of Ga-67 citrate and Tc-99m MDP and reversible liver uptake of Tc-99m MDP was seen in a patient with hypercalcemia of lymphoma and biopsy-proven metastatic pulmonary calcification. tc-99 89-94 dipeptidase 1 Homo sapiens 96-99 3527509-2 1986 Abnormal lung uptake of Tc-99m MDP may confirm the diagnosis of pulmonary calcification, lessening the need for invasive procedures to evaluate pathologic lung uptake of Ga-67 citrate. tc-99 24-29 dipeptidase 1 Homo sapiens 31-34 3527509-2 1986 Abnormal lung uptake of Tc-99m MDP may confirm the diagnosis of pulmonary calcification, lessening the need for invasive procedures to evaluate pathologic lung uptake of Ga-67 citrate. gallium citrate 170-183 dipeptidase 1 Homo sapiens 31-34 3698433-0 1986 Extraosseous uptake of technetium-99m MDP in secondary deposits of neuroblastoma. Technetium-99 23-36 dipeptidase 1 Homo sapiens 38-41 3770911-1 1986 Eighty patients who had sustained a fracture of the tibial shaft were studied by scintigraphy using technetium-99m labelled methylene diphosphonate (99Tcm MDP) and a gamma camera. methylene diphosphonate 124-147 dipeptidase 1 Homo sapiens 155-158 3527628-1 1986 MDP (N-acetylmuramyl-L-alanyl-D-isoglutamine), the first synthetic peptidoglycan derivative capable of replacing whole mycobacteria in Freund"s complete adjuvant, is highly active in stimulating antibody production. Acetylmuramyl-Alanyl-Isoglutamine 5-44 dipeptidase 1 Homo sapiens 0-3 3161679-0 1985 Extensive soft tissue uptake of technetium-99m MDP in a patient with breast cancer. Technetium 32-42 dipeptidase 1 Homo sapiens 47-50 4075669-0 1985 Dermal uptake of technetium-99m MDP in calcinosis cutis. Technetium-99 17-30 dipeptidase 1 Homo sapiens 32-35 4075669-1 1985 A rare case of extensive dermal uptake of Tc-99m MDP associated with renal failure is reported. tc-99 42-47 dipeptidase 1 Homo sapiens 49-52 4075669-2 1985 The mechanism of Tc-99m MDP uptake in such examples of metastatic calcification is not proved, but may relate to adsorption onto hydroxyapatite crystals. tc-99 17-22 dipeptidase 1 Homo sapiens 24-27 4075669-2 1985 The mechanism of Tc-99m MDP uptake in such examples of metastatic calcification is not proved, but may relate to adsorption onto hydroxyapatite crystals. Durapatite 129-143 dipeptidase 1 Homo sapiens 24-27 4045556-2 1985 Similar studies in the same normal subjects and patients were carried out with 99mTc-methylene-bisphosphonate ([99mTc]MDP). 99mtc-methylene-bisphosphonate 79-109 dipeptidase 1 Homo sapiens 118-121 3863619-1 1985 The metabolism of leukotriene D4 to leukotriene E4 by a dipeptidase of kidney tissue is strongly inhibited by cilastatin (MK 0791) a known renal dehydropeptidase-I inhibitor. Leukotriene D4 18-32 dipeptidase 1 Homo sapiens 145-163 3863619-1 1985 The metabolism of leukotriene D4 to leukotriene E4 by a dipeptidase of kidney tissue is strongly inhibited by cilastatin (MK 0791) a known renal dehydropeptidase-I inhibitor. Leukotriene E4 36-50 dipeptidase 1 Homo sapiens 145-163 3863619-1 1985 The metabolism of leukotriene D4 to leukotriene E4 by a dipeptidase of kidney tissue is strongly inhibited by cilastatin (MK 0791) a known renal dehydropeptidase-I inhibitor. Cilastatin 110-120 dipeptidase 1 Homo sapiens 145-163 3863619-1 1985 The metabolism of leukotriene D4 to leukotriene E4 by a dipeptidase of kidney tissue is strongly inhibited by cilastatin (MK 0791) a known renal dehydropeptidase-I inhibitor. Cilastatin 122-129 dipeptidase 1 Homo sapiens 145-163 3862492-2 1985 The combination of the lung hypoperfusion and accumulation of the Tc-99m MDP and Ga-67 citrate in the same area suggested the preoperative diagnosis of mediastinal neuroblastoma. tc-99 66-71 dipeptidase 1 Homo sapiens 73-76 3863219-1 1985 Imipenem/cilastatin sodium consists of imipenem, a broad-spectrum carbapenem antimicrobial agent, and cilastatin sodium, an inhibitor of dehydropeptidase I, the renal enzyme that catalyzes the metabolism of imipenem. Imipenem 0-8 dipeptidase 1 Homo sapiens 137-155 3863219-1 1985 Imipenem/cilastatin sodium consists of imipenem, a broad-spectrum carbapenem antimicrobial agent, and cilastatin sodium, an inhibitor of dehydropeptidase I, the renal enzyme that catalyzes the metabolism of imipenem. Cilastatin 9-26 dipeptidase 1 Homo sapiens 137-155 3863219-1 1985 Imipenem/cilastatin sodium consists of imipenem, a broad-spectrum carbapenem antimicrobial agent, and cilastatin sodium, an inhibitor of dehydropeptidase I, the renal enzyme that catalyzes the metabolism of imipenem. Cilastatin 102-119 dipeptidase 1 Homo sapiens 137-155 3863219-1 1985 Imipenem/cilastatin sodium consists of imipenem, a broad-spectrum carbapenem antimicrobial agent, and cilastatin sodium, an inhibitor of dehydropeptidase I, the renal enzyme that catalyzes the metabolism of imipenem. Imipenem 207-215 dipeptidase 1 Homo sapiens 137-155 3863220-1 1985 Imipenem is renally metabolized to the stable open-lactam metabolite by a dipeptidase, dehydropeptidase I, located at the lumenal surface of the proximal tubular cells. Imipenem 0-8 dipeptidase 1 Homo sapiens 87-105 3863220-1 1985 Imipenem is renally metabolized to the stable open-lactam metabolite by a dipeptidase, dehydropeptidase I, located at the lumenal surface of the proximal tubular cells. Lactams 51-57 dipeptidase 1 Homo sapiens 87-105 3901213-2 1985 The efficacy and toxicity of this drug, when administered parenterally in combination with the dehydropeptidase I inhibitor cilastatin, were studied in 41 hospitalized patients with serious infections. Cilastatin 124-134 dipeptidase 1 Homo sapiens 95-113 3867330-1 1985 Cilastatin inhibits dehydropeptidase-I, a zinc metaloenzyme that metabolizes imipenem. Cilastatin 0-10 dipeptidase 1 Homo sapiens 20-38 3867330-1 1985 Cilastatin inhibits dehydropeptidase-I, a zinc metaloenzyme that metabolizes imipenem. Imipenem 77-85 dipeptidase 1 Homo sapiens 20-38 2933203-0 1985 Accumulation of technetium-99m MDP in distended ureter. Technetium 16-30 dipeptidase 1 Homo sapiens 31-34 3160524-2 1985 A well localized hyperactive area on a Tc-99m MDP bone scan provided the correct diagnosis. Technetium 39-41 dipeptidase 1 Homo sapiens 46-49 3859242-1 1985 Imipenem and its renal dehydropeptidase I inhibitor, cilastatin, were coadministered intravenously in a 1:1 ratio to 30 newborns. Cilastatin 53-63 dipeptidase 1 Homo sapiens 23-41 6334084-1 1984 Human renal dipeptidase has been concentrated from kidneys by homogenization, 1-butanol solubilization, and (NH4)2SO4 fractionation. 1-Butanol 78-87 dipeptidase 1 Homo sapiens 6-23 3980311-2 1985 When it is combined with the renal dipeptidase inhibitor cilastatin (MK-0791) the combination is known as primaxin. Cilastatin 57-67 dipeptidase 1 Homo sapiens 29-46 3980311-2 1985 When it is combined with the renal dipeptidase inhibitor cilastatin (MK-0791) the combination is known as primaxin. Cilastatin 69-76 dipeptidase 1 Homo sapiens 29-46 3980311-2 1985 When it is combined with the renal dipeptidase inhibitor cilastatin (MK-0791) the combination is known as primaxin. Cilastatin, Imipenem Drug Combination 106-114 dipeptidase 1 Homo sapiens 29-46 3159575-1 1985 Three cases (rhabdomyosarcoma, lymphoma, and metastatic malignant melanoma) of unexpected increased uptake of methylenediphosphonate labelled by technetium 99m sodium pertechnetate (99mTc-MDP) are described. methylene diphosphonate 110-132 dipeptidase 1 Homo sapiens 188-191 3159575-1 1985 Three cases (rhabdomyosarcoma, lymphoma, and metastatic malignant melanoma) of unexpected increased uptake of methylenediphosphonate labelled by technetium 99m sodium pertechnetate (99mTc-MDP) are described. Sodium Pertechnetate Tc 99m 160-180 dipeptidase 1 Homo sapiens 188-191 6334084-1 1984 Human renal dipeptidase has been concentrated from kidneys by homogenization, 1-butanol solubilization, and (NH4)2SO4 fractionation. Ammonium Sulfate 108-117 dipeptidase 1 Homo sapiens 6-23 6334084-5 1984 Dissociation of human renal dipeptidase in sodium dodecyl sulfate-polyacrylamide gel electrophoresis produced a single polypeptide (Mr 59,000). Sodium Dodecyl Sulfate 43-65 dipeptidase 1 Homo sapiens 22-39 6334084-5 1984 Dissociation of human renal dipeptidase in sodium dodecyl sulfate-polyacrylamide gel electrophoresis produced a single polypeptide (Mr 59,000). polyacrylamide 66-80 dipeptidase 1 Homo sapiens 22-39 6595962-9 1984 The open lactam metabolite, resulting from the metabolism of imipenem in the kidneys by a dipeptidase, dehydropeptidase-I, represented 80 to 90% of the effluent radioactivity when imipenem was given alone and about 20% when cilastatin sodium was coadministered. Lactams 9-15 dipeptidase 1 Homo sapiens 103-121 6595962-9 1984 The open lactam metabolite, resulting from the metabolism of imipenem in the kidneys by a dipeptidase, dehydropeptidase-I, represented 80 to 90% of the effluent radioactivity when imipenem was given alone and about 20% when cilastatin sodium was coadministered. Imipenem 61-69 dipeptidase 1 Homo sapiens 103-121 6595962-9 1984 The open lactam metabolite, resulting from the metabolism of imipenem in the kidneys by a dipeptidase, dehydropeptidase-I, represented 80 to 90% of the effluent radioactivity when imipenem was given alone and about 20% when cilastatin sodium was coadministered. Imipenem 180-188 dipeptidase 1 Homo sapiens 103-121 6595962-9 1984 The open lactam metabolite, resulting from the metabolism of imipenem in the kidneys by a dipeptidase, dehydropeptidase-I, represented 80 to 90% of the effluent radioactivity when imipenem was given alone and about 20% when cilastatin sodium was coadministered. Cilastatin 224-241 dipeptidase 1 Homo sapiens 103-121 6235885-4 1984 The 51Cr EDTA level corrects for the glomerular filtration of 99Tcm MDP. Edetic Acid 9-13 dipeptidase 1 Homo sapiens 68-71 3859213-7 1985 A renal dipeptidase, dehydropeptidase-I, was responsible for hydrolyzing imipenem and other carbapenems. Imipenem 73-81 dipeptidase 1 Homo sapiens 2-19 3859213-7 1985 A renal dipeptidase, dehydropeptidase-I, was responsible for hydrolyzing imipenem and other carbapenems. Imipenem 73-81 dipeptidase 1 Homo sapiens 21-39 3859213-7 1985 A renal dipeptidase, dehydropeptidase-I, was responsible for hydrolyzing imipenem and other carbapenems. Carbapenems 92-103 dipeptidase 1 Homo sapiens 2-19 3859213-7 1985 A renal dipeptidase, dehydropeptidase-I, was responsible for hydrolyzing imipenem and other carbapenems. Carbapenems 92-103 dipeptidase 1 Homo sapiens 21-39 6575782-1 1983 The beta-lactam antibiotic thienamycin is rather unstable and is metabolized in man by renal dehydropeptidase-I. thienamycin 27-38 dipeptidase 1 Homo sapiens 93-111 6546258-5 1984 It seems that uptake of Tc-99m MDP increases with the degree of calcification rather than whether the lesion is benign or malignant. tc-99 24-29 dipeptidase 1 Homo sapiens 31-34 6607914-4 1983 Imipenem was found to be hydrolysed by renal dehydropeptidase-I residing on the luminal surface of the renal tubular epithelium. Imipenem 0-8 dipeptidase 1 Homo sapiens 45-63 6607914-5 1983 A dehydropeptidase-I inhibitor, cilastatin (MK-0791) was developed with specific inhibitory activity toward the renal dehydropeptidase-I and showed detectable effects in humans. Cilastatin 32-42 dipeptidase 1 Homo sapiens 2-20 6607914-5 1983 A dehydropeptidase-I inhibitor, cilastatin (MK-0791) was developed with specific inhibitory activity toward the renal dehydropeptidase-I and showed detectable effects in humans. Cilastatin 32-42 dipeptidase 1 Homo sapiens 118-136 6607914-5 1983 A dehydropeptidase-I inhibitor, cilastatin (MK-0791) was developed with specific inhibitory activity toward the renal dehydropeptidase-I and showed detectable effects in humans. Cilastatin 44-51 dipeptidase 1 Homo sapiens 2-20 6607914-5 1983 A dehydropeptidase-I inhibitor, cilastatin (MK-0791) was developed with specific inhibitory activity toward the renal dehydropeptidase-I and showed detectable effects in humans. Cilastatin 44-51 dipeptidase 1 Homo sapiens 118-136 6885638-3 1983 The procedure is based on the incubation of carbapenem-containing solutions with dehydropeptidase-I and the subsequent assay of residual beta-lactamase-inhibiting/inactivating activity of carbapenems by means of a plate technique using the chromogenic beta-lactamase substrate PADAC. Carbapenems 44-54 dipeptidase 1 Homo sapiens 81-99 6573157-1 1983 N-Formimidoyl thienamycin (MK0787) undergoes renal metabolism by a dipeptidase, dehydropeptidase I, located on the brush border of the proximal tubular cells. Imipenem 0-25 dipeptidase 1 Homo sapiens 80-98 6573157-1 1983 N-Formimidoyl thienamycin (MK0787) undergoes renal metabolism by a dipeptidase, dehydropeptidase I, located on the brush border of the proximal tubular cells. Imipenem 27-33 dipeptidase 1 Homo sapiens 80-98 6573157-2 1983 The effects of two inhibitors (MK-789 and MK-791) of dehydropeptidase I on the pharmacokinetics of N-formimidoyl thienamycin were studied in 41 healthy subjects receiving various combinations of N-formimidoyl thienamycin and MK-789 or MK-791. MK 789 31-37 dipeptidase 1 Homo sapiens 53-71 6573157-2 1983 The effects of two inhibitors (MK-789 and MK-791) of dehydropeptidase I on the pharmacokinetics of N-formimidoyl thienamycin were studied in 41 healthy subjects receiving various combinations of N-formimidoyl thienamycin and MK-789 or MK-791. Cilastatin 42-48 dipeptidase 1 Homo sapiens 53-71 6573157-2 1983 The effects of two inhibitors (MK-789 and MK-791) of dehydropeptidase I on the pharmacokinetics of N-formimidoyl thienamycin were studied in 41 healthy subjects receiving various combinations of N-formimidoyl thienamycin and MK-789 or MK-791. Imipenem 99-124 dipeptidase 1 Homo sapiens 53-71 6575782-1 1983 The beta-lactam antibiotic thienamycin is rather unstable and is metabolized in man by renal dehydropeptidase-I. beta-Lactams 4-15 dipeptidase 1 Homo sapiens 93-111 6332794-1 1984 Synthetic N-acetylmuramyl-L-alanyl-D-isoglutamine, also called MDP for muramyl dipeptide, is a copy of a fragment of bacterial peptidoglycan. Acetylmuramyl-Alanyl-Isoglutamine 10-49 dipeptidase 1 Homo sapiens 63-66 6332794-1 1984 Synthetic N-acetylmuramyl-L-alanyl-D-isoglutamine, also called MDP for muramyl dipeptide, is a copy of a fragment of bacterial peptidoglycan. Dipeptides 79-88 dipeptidase 1 Homo sapiens 63-66 6652634-0 1983 Chemical modification of the C-6 substituent in the carbohydrate moiety of N-acetylmuramoyl-L-alanyl-D-isoglutamine (MDP), and the immunoadjuvant activity. Carbohydrates 52-64 dipeptidase 1 Homo sapiens 117-120 6652634-0 1983 Chemical modification of the C-6 substituent in the carbohydrate moiety of N-acetylmuramoyl-L-alanyl-D-isoglutamine (MDP), and the immunoadjuvant activity. n-acetylmuramoyl-l-alanyl-d-isoglutamine 75-115 dipeptidase 1 Homo sapiens 117-120 6358177-3 1983 All eleven patients treated with thienamycin formamidine/renal dipeptidase inhibitor responded well to therapy. thienamycin formamidine 33-56 dipeptidase 1 Homo sapiens 57-74 6224402-5 1983 Uptake of technetium-99m methylene diphosphate (99mTc-MDP) by the primary tumor occurred in 20 of 27 cases, but correlation between tumor uptake and calcification was not statistically significant. technetium-99m methylene diphosphate 10-46 dipeptidase 1 Homo sapiens 54-57 6358804-1 1983 Synthetic N-acetylmuramyl-L-alanyl-D-isoglutamine, also called MDP for muramyl dipeptide, is a copy of a fragment of bacterial peptidoglycan. Acetylmuramyl-Alanyl-Isoglutamine 10-49 dipeptidase 1 Homo sapiens 63-66 6620356-5 1983 Demembranation of the microvilli with Triton X-100 resulted in a distribution of 68% of renal dipeptidase in the insoluble pellet and 32% in the soluble supernatant. Octoxynol 38-50 dipeptidase 1 Homo sapiens 88-105 6620356-9 1983 Finally extraction of Triton-insoluble pellet with 0.05 mM ATP-0.10 mM MgCl2 X 6 H2O solubilized 57% of the renal dipeptidase. Adenosine Triphosphate 59-62 dipeptidase 1 Homo sapiens 108-125 6620356-9 1983 Finally extraction of Triton-insoluble pellet with 0.05 mM ATP-0.10 mM MgCl2 X 6 H2O solubilized 57% of the renal dipeptidase. Magnesium Chloride 71-76 dipeptidase 1 Homo sapiens 108-125 6620356-9 1983 Finally extraction of Triton-insoluble pellet with 0.05 mM ATP-0.10 mM MgCl2 X 6 H2O solubilized 57% of the renal dipeptidase. Water 81-84 dipeptidase 1 Homo sapiens 108-125 6358804-1 1983 Synthetic N-acetylmuramyl-L-alanyl-D-isoglutamine, also called MDP for muramyl dipeptide, is a copy of a fragment of bacterial peptidoglycan. Dipeptides 79-88 dipeptidase 1 Homo sapiens 63-66 6358804-2 1983 Soon after the recognition of MDP as being the minimal subunit responsible for the activity of Freund"s complete adjuvant, a great number of derivatives were synthesized. freund"s complete 95-112 dipeptidase 1 Homo sapiens 30-33 985477-0 1976 Correlation of structure and adjuvant activity of N-acetyl muramyl-L-alanyl-D-isoglutamine (MDP), its derivatives and analogues. Acetylmuramyl-Alanyl-Isoglutamine 50-90 dipeptidase 1 Homo sapiens 92-95 6983880-0 1982 beta-Lactamase activity of renal dipeptidase against N-formimidoyl-thienamycin. Imipenem 53-78 dipeptidase 1 Homo sapiens 27-44 7161762-7 1982 Liposomes provide an effective means of enhancing the uptake of MDP derivatives (3H nor MDP) by monocytes, with a 20-fold greater uptake of liposome encapsulated drug than of the free compound. Tritium 81-83 dipeptidase 1 Homo sapiens 64-67 6283869-1 1982 Technetium-99m methylene diphosphonate (99mTc MDP) imaging was performed in 29 consecutive children with abdominal masses. Technetium 0-10 dipeptidase 1 Homo sapiens 46-49 6283869-1 1982 Technetium-99m methylene diphosphonate (99mTc MDP) imaging was performed in 29 consecutive children with abdominal masses. methylene diphosphonate 15-38 dipeptidase 1 Homo sapiens 46-49 6460204-2 1982 Myocardioscintigraphy with 99mTc MDP is patients undergoing protracted treatment with adriblastin led to the discovery that accumulation of the isotope was infrequent in subjects protected with strophanthin and vitamin E, contrary to the position in an earlier series for whom no treatment designed to reduce the cardiotoxic effect of the antiblastic drug had been provided. Doxorubicin 86-97 dipeptidase 1 Homo sapiens 33-36 7296716-0 1981 Chemical synthesis and adjuvant activity of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) analogs 1, 2. Acetylmuramyl-Alanyl-Isoglutamine 44-83 dipeptidase 1 Homo sapiens 85-88 7442679-0 1980 Synthesis of conjugates containing N-acetylmuramyl-L-alanyl-D-isoglutaminyl (MDP). n-acetylmuramyl-l-alanyl-d-isoglutaminyl 35-75 dipeptidase 1 Homo sapiens 77-80 7205942-17 1980 Analysis of the microvilli for renal dipeptidase, an enzyme with hydrolytic activity against a wide range of L-dipeptides, revealed this enzyme to be enriched in the microvilli vesicles to a degree equivalent to that observed for marker enzymes for renal microvilli. l-dipeptides 109-121 dipeptidase 1 Homo sapiens 31-48 7205942-18 1980 Renal dipeptidase catalyzed hydrolysis of L-Ala.Gly but not D-Ala.Gly, as was the case with microvilli-catalyzed hydrolysis of the dipeptides. polyalanine 42-47 dipeptidase 1 Homo sapiens 0-17 7205942-18 1980 Renal dipeptidase catalyzed hydrolysis of L-Ala.Gly but not D-Ala.Gly, as was the case with microvilli-catalyzed hydrolysis of the dipeptides. Glycine 48-51 dipeptidase 1 Homo sapiens 0-17 7205942-18 1980 Renal dipeptidase catalyzed hydrolysis of L-Ala.Gly but not D-Ala.Gly, as was the case with microvilli-catalyzed hydrolysis of the dipeptides. Glycine 66-69 dipeptidase 1 Homo sapiens 0-17 7205942-18 1980 Renal dipeptidase catalyzed hydrolysis of L-Ala.Gly but not D-Ala.Gly, as was the case with microvilli-catalyzed hydrolysis of the dipeptides. Dipeptides 131-141 dipeptidase 1 Homo sapiens 0-17 7205942-19 1980 With its location in the renal brush border microvilli and its hydrolytic action against L-dipeptides, renal dipeptidase my act at the luminal surface of the proximal tubule cell to hydrolyze L-dipeptides present in the glomerular filtrate, with the resultant free amino acids transported across the brush border microvilli by Na+ gradient-dependent processes. l-dipeptides 89-101 dipeptidase 1 Homo sapiens 103-120 7205942-19 1980 With its location in the renal brush border microvilli and its hydrolytic action against L-dipeptides, renal dipeptidase my act at the luminal surface of the proximal tubule cell to hydrolyze L-dipeptides present in the glomerular filtrate, with the resultant free amino acids transported across the brush border microvilli by Na+ gradient-dependent processes. l-dipeptides 192-204 dipeptidase 1 Homo sapiens 103-120 291792-1 1979 Some cases of more or less evident reduction in 99mTc MDP take-up by bone subjected to cobalt therapy for skeletal and extraskeletal neoplastic diseases are presented. Cobalt 87-93 dipeptidase 1 Homo sapiens 54-57 852928-1 1977 A relatively easy synthetic method is reported for the production of the immunoadjuvant glycopeptide, N-acetyl-muramy-L-alanyl-D-isoglutamine (MDP). Glycopeptides 88-100 dipeptidase 1 Homo sapiens 143-146 852928-1 1977 A relatively easy synthetic method is reported for the production of the immunoadjuvant glycopeptide, N-acetyl-muramy-L-alanyl-D-isoglutamine (MDP). n-acetyl-muramy-l-alanyl-d-isoglutamine 102-141 dipeptidase 1 Homo sapiens 143-146 7319546-1 1981 Adjuvant activities of fatty acid derivatives of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) in saline, emulsified in Incomplete Freund Adjuvant (IFA) or incorporated in liposomes were compared. Fatty Acids 23-33 dipeptidase 1 Homo sapiens 90-93 7319546-1 1981 Adjuvant activities of fatty acid derivatives of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) in saline, emulsified in Incomplete Freund Adjuvant (IFA) or incorporated in liposomes were compared. Sodium Chloride 98-104 dipeptidase 1 Homo sapiens 90-93 701793-1 1978 The binding of the synthetic immunoadjuvant N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP, for muramyl dipeptide) to human and rabbit sera containing peptidoglycan (PG) antibodies was investigated. Acetylmuramyl-Alanyl-Isoglutamine 44-84 dipeptidase 1 Homo sapiens 86-89 701793-1 1978 The binding of the synthetic immunoadjuvant N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP, for muramyl dipeptide) to human and rabbit sera containing peptidoglycan (PG) antibodies was investigated. Acetylmuramyl-Alanyl-Isoglutamine 95-112 dipeptidase 1 Homo sapiens 86-89 701793-3 1978 Whereas MDP did not react with naturally occurring or experimentally induced PG-antibodies, the analog of MDP MDP-L-Lys-D-Ala did bind to hyperimmune rabbit anti-PG sera, but not to the human sera tested. l-lys-d-ala 114-125 dipeptidase 1 Homo sapiens 106-109 701793-3 1978 Whereas MDP did not react with naturally occurring or experimentally induced PG-antibodies, the analog of MDP MDP-L-Lys-D-Ala did bind to hyperimmune rabbit anti-PG sera, but not to the human sera tested. l-lys-d-ala 114-125 dipeptidase 1 Homo sapiens 106-109 669885-0 1978 Synthesis of some new analogs of the immunoadjuvant glycopeptide MDP (N-acetyl-muramyl-L-alanyl-D-isoglutamine). Acetylmuramyl-Alanyl-Isoglutamine 70-110 dipeptidase 1 Homo sapiens 65-68 669885-1 1978 In our continued efforts to elucidate the relationship between the structure and the immunoadjuvant, antiinfectious or mitogenic activity of N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP), we report the synthesis of 11 new analogs. Acetylmuramyl-Alanyl-Isoglutamine 141-181 dipeptidase 1 Homo sapiens 183-186 48-5 1975 Cyanide ion produced a much more effective inhibition of renal dipeptidase than the other monoanions, and it was shown that two cyanide ions were bound per enzyme molecule. Cyanides 0-7 dipeptidase 1 Homo sapiens 57-74 48-5 1975 Cyanide ion produced a much more effective inhibition of renal dipeptidase than the other monoanions, and it was shown that two cyanide ions were bound per enzyme molecule. Cyanides 128-135 dipeptidase 1 Homo sapiens 57-74 48-8 1975 The 35Cl line broadening produced by renal dipeptidase in 0.5 M NaCl solutions was 100 times more effective than that produced by equivalent concentrations of aquozinc(II). Sodium Chloride 64-68 dipeptidase 1 Homo sapiens 37-54 48-11 1975 Treatment of renal dipeptidase with saturating concentrations of the competitive inhibitor, guanosine triphosphate, in the presence of 0.5 M NaCl also produced a significant decrease in the 35Cl line width. Guanosine Triphosphate 92-114 dipeptidase 1 Homo sapiens 13-30 48-11 1975 Treatment of renal dipeptidase with saturating concentrations of the competitive inhibitor, guanosine triphosphate, in the presence of 0.5 M NaCl also produced a significant decrease in the 35Cl line width. Sodium Chloride 141-145 dipeptidase 1 Homo sapiens 13-30 6020444-0 1967 Reactions of renal dipeptidase and cupric ions with unsaturated dipeptides. Dipeptides 64-74 dipeptidase 1 Homo sapiens 13-30 32896379-8 2020 In function, the MTT, EdU, Clone Formation assays and xenograft tumors assays demonstrated that DPEP1 could boost the proliferation of colon cancer cells through the DPEP1/MYC positive feedback loop in vitro and in vivo. ethylene diurea 22-25 dipeptidase 1 Homo sapiens 96-101 33513824-4 2021 Cilastatin is a selective inhibitor of renal dehydropeptidase I in the proximal renal tubule cells that can reduce the nephrotoxicity of cisplatin. Cilastatin 0-10 dipeptidase 1 Homo sapiens 45-63 33513824-4 2021 Cilastatin is a selective inhibitor of renal dehydropeptidase I in the proximal renal tubule cells that can reduce the nephrotoxicity of cisplatin. Cisplatin 137-146 dipeptidase 1 Homo sapiens 45-63 32896379-8 2020 In function, the MTT, EdU, Clone Formation assays and xenograft tumors assays demonstrated that DPEP1 could boost the proliferation of colon cancer cells through the DPEP1/MYC positive feedback loop in vitro and in vivo. monooxyethylene trimethylolpropane tristearate 17-20 dipeptidase 1 Homo sapiens 96-101 33630278-1 2021 Imipenem/cilastatin/relebactam (Recarbrio ) is an intravenously administered combination of the carbapenem imipenem, the renal dehydropeptidase-I inhibitor cilastatin, and the novel beta-lactamase inhibitor relebactam. imipenem/cilastatin/relebactam 0-30 dipeptidase 1 Homo sapiens 127-145 33630278-1 2021 Imipenem/cilastatin/relebactam (Recarbrio ) is an intravenously administered combination of the carbapenem imipenem, the renal dehydropeptidase-I inhibitor cilastatin, and the novel beta-lactamase inhibitor relebactam. relebactam 20-30 dipeptidase 1 Homo sapiens 127-145 32325220-7 2020 However, DPEP3 diverges from DPEP1 and DPEP2 in key positions of its active site: a histidine to tyrosine variation at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance, whereas an aspartate to asparagine change at position 359 abolishes activation of the nucleophilic water/hydroxide, resulting in no in vitro activity against a variety of dipeptides and biological substrates (imipenem, leukotriene D4 and cystinyl-bis-glycine). Water 308-313 dipeptidase 1 Homo sapiens 29-34 32325220-7 2020 However, DPEP3 diverges from DPEP1 and DPEP2 in key positions of its active site: a histidine to tyrosine variation at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance, whereas an aspartate to asparagine change at position 359 abolishes activation of the nucleophilic water/hydroxide, resulting in no in vitro activity against a variety of dipeptides and biological substrates (imipenem, leukotriene D4 and cystinyl-bis-glycine). hydroxide ion 314-323 dipeptidase 1 Homo sapiens 29-34 32325220-7 2020 However, DPEP3 diverges from DPEP1 and DPEP2 in key positions of its active site: a histidine to tyrosine variation at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance, whereas an aspartate to asparagine change at position 359 abolishes activation of the nucleophilic water/hydroxide, resulting in no in vitro activity against a variety of dipeptides and biological substrates (imipenem, leukotriene D4 and cystinyl-bis-glycine). Dipeptides 380-390 dipeptidase 1 Homo sapiens 29-34 32325220-7 2020 However, DPEP3 diverges from DPEP1 and DPEP2 in key positions of its active site: a histidine to tyrosine variation at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance, whereas an aspartate to asparagine change at position 359 abolishes activation of the nucleophilic water/hydroxide, resulting in no in vitro activity against a variety of dipeptides and biological substrates (imipenem, leukotriene D4 and cystinyl-bis-glycine). Imipenem 418-426 dipeptidase 1 Homo sapiens 29-34 32325220-7 2020 However, DPEP3 diverges from DPEP1 and DPEP2 in key positions of its active site: a histidine to tyrosine variation at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance, whereas an aspartate to asparagine change at position 359 abolishes activation of the nucleophilic water/hydroxide, resulting in no in vitro activity against a variety of dipeptides and biological substrates (imipenem, leukotriene D4 and cystinyl-bis-glycine). Leukotriene D4 428-442 dipeptidase 1 Homo sapiens 29-34 31541079-9 2019 Mechanistically, our results indicated that the miR-193a-5p/DPEP1 axis participated to the progression of HB via regulating the PI3K/Akt/mTOR (phosphatidylinositol-3-kinase/Akt/mammalian target of rapamycin) signaling. Phosphatidylinositols 143-163 dipeptidase 1 Homo sapiens 60-65 31200653-1 2019 BACKGROUND: Cilastatin (CL) is an inhibitor of dehydropeptidase-I, which is safely used in clinical practice to prevent nephrotoxicity of antibiotics. Cilastatin 12-22 dipeptidase 1 Homo sapiens 47-65 32373203-8 2020 But, cilastatin significantly inhibited the uptake of imipenem when dehydropeptidase-1 (DPEP1) was silenced by RNAi technology in hOAT1- and hOAT3-HEK 293 cells. Cilastatin 5-15 dipeptidase 1 Homo sapiens 68-86 32373203-8 2020 But, cilastatin significantly inhibited the uptake of imipenem when dehydropeptidase-1 (DPEP1) was silenced by RNAi technology in hOAT1- and hOAT3-HEK 293 cells. Cilastatin 5-15 dipeptidase 1 Homo sapiens 88-93 32373203-8 2020 But, cilastatin significantly inhibited the uptake of imipenem when dehydropeptidase-1 (DPEP1) was silenced by RNAi technology in hOAT1- and hOAT3-HEK 293 cells. Imipenem 54-62 dipeptidase 1 Homo sapiens 68-86 32373203-8 2020 But, cilastatin significantly inhibited the uptake of imipenem when dehydropeptidase-1 (DPEP1) was silenced by RNAi technology in hOAT1- and hOAT3-HEK 293 cells. Imipenem 54-62 dipeptidase 1 Homo sapiens 88-93 31085457-7 2019 Samples bonded with resin cement containing MDP had a significant reduction in their fatigue failure load when Y-TZP was air-abraded with aluminum oxide particles and subjected to aging (MDP-AO = 2050.71A; MDP-AO/AG = 1756.67B). y-tzp 111-116 dipeptidase 1 Homo sapiens 44-47 31085457-7 2019 Samples bonded with resin cement containing MDP had a significant reduction in their fatigue failure load when Y-TZP was air-abraded with aluminum oxide particles and subjected to aging (MDP-AO = 2050.71A; MDP-AO/AG = 1756.67B). Aluminum Oxide 138-152 dipeptidase 1 Homo sapiens 44-47 31085457-12 2019 The MDP-containing resin cement applied on aluminum oxide air-abraded zirconia surface was not enough to maintain the fatigue performance after aging, while higher stability to aging was achieved by treating with the tribochemical silica coating method. Aluminum Oxide 43-57 dipeptidase 1 Homo sapiens 4-7