PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23346879-8	2013	In oocytes, the mRNA level of Cdc25C, an activator of Cdc2, was increased by HDACm-FLAG mRNA-injection; in contrast, the mRNA level of Cdc2 inhibitor Wee1 was increased by TSA treatment.	trichostatin A	172-175	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	150-154
18395197-5	2008	We report that TCS elements exert translational repression in both the Wee1 mRNA 3" UTR and the pericentriolar material-1 (Pcm-1) mRNA 3" UTR in immature oocytes.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	15-18	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	71-75
22732570-2	2012	The Translational Control Sequence (TCS) in the 3" untranslated region (UTR) of the maternal mRNA, Wee1, mediates translational repression in immature Xenopus oocytes and translational activation in mature oocytes, but the protein that binds to the TCS and mediates translational control is not known.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	36-39	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	99-103
22732570-3	2012	Here we show that Xenopus laevis Zar2 (encoded by zar2) binds to the TCS in maternal Wee1 mRNA and represses translation in immature oocytes.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	69-72	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	85-89
18395197-7	2008	By contrast, we demonstrate that CPE sequences flanking the TCS elements in the Wee1 3" UTR suppress the ability of the TCS to direct early translational activation.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	60-63	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	80-84
18395197-7	2008	By contrast, we demonstrate that CPE sequences flanking the TCS elements in the Wee1 3" UTR suppress the ability of the TCS to direct early translational activation.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	120-123	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	80-84
17961226-6	2007	Overexpression of Wee1 caused cell cycle delay and tyrosine phosphorylation of Cdks prior to the MBT.	Tyrosine	51-59	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	18-22
17961226-8	2007	Overexpression of Wee1 also resulted in post-MBT apoptosis, tyrosine phosphorylation of Cdks and persistence of cyclin E/Cdk2 activity.	Tyrosine	60-68	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	18-22
11134069-15	2000	We have demonstrated a specific interaction between tyrosine-phosphorylated Wee1 and the Crk SH2 domain and have shown that recombinant Wee1 can restore apoptosis to an extract depleted of SH2 interactors.	Tyrosine	52-60	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	76-80
14711880-4	2004	By depleting Wee1 protein levels using antisense morpholino oligonucleotides, we show that Wee1 regulates M-phase entry and Cdc2 tyrosine phosphorylation in early gastrula embryos.	Morpholinos	49-76	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	13-17
14711880-4	2004	By depleting Wee1 protein levels using antisense morpholino oligonucleotides, we show that Wee1 regulates M-phase entry and Cdc2 tyrosine phosphorylation in early gastrula embryos.	Morpholinos	49-76	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	91-95
14711880-4	2004	By depleting Wee1 protein levels using antisense morpholino oligonucleotides, we show that Wee1 regulates M-phase entry and Cdc2 tyrosine phosphorylation in early gastrula embryos.	Tyrosine	129-137	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	13-17
14711880-4	2004	By depleting Wee1 protein levels using antisense morpholino oligonucleotides, we show that Wee1 regulates M-phase entry and Cdc2 tyrosine phosphorylation in early gastrula embryos.	Tyrosine	129-137	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	91-95
14711880-6	2004	In addition, Wee1 is positively regulated by tyrosine autophosphorylation in early gastrula embryos and this upregulation of Wee1 activity is required for normal gastrulation.	Tyrosine	45-53	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	13-17
14711880-6	2004	In addition, Wee1 is positively regulated by tyrosine autophosphorylation in early gastrula embryos and this upregulation of Wee1 activity is required for normal gastrulation.	Tyrosine	45-53	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	125-129
11251070-1	2001	Wee1 inactivates the Cdc2-cyclin B complex during interphase by phosphorylating Cdc2 on Tyr-15.	Tyrosine	88-91	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	0-4
11251070-5	2001	Binding of 14-3-3 to Xwee1 occurs during interphase, but not M-phase, and requires phosphorylation of Xwee1 on Ser-549.	Serine	111-114	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	21-26
11251070-5	2001	Binding of 14-3-3 to Xwee1 occurs during interphase, but not M-phase, and requires phosphorylation of Xwee1 on Ser-549.	Serine	111-114	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	102-107
11251070-8	2001	In cell-free kinase assays, Xchk1 phosphorylates Xwee1 on Ser-549.	Serine	58-61	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	49-54
11134069-15	2000	We have demonstrated a specific interaction between tyrosine-phosphorylated Wee1 and the Crk SH2 domain and have shown that recombinant Wee1 can restore apoptosis to an extract depleted of SH2 interactors.	Tyrosine	52-60	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	136-140
8573790-6	1995	Dwee1 kinase is closely related to human and Xenopus Wee1 homologues, and can inhibit Cdc2 activity by phosphorylating a critical tyrosine residue.	Tyrosine	130-138	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	53-57
10601234-2	1999	In Xenopus egg extracts, the inhibitory phosphorylations of Cdc2 on Tyr-15 and Thr-14 are controlled by the phosphatase Cdc25 and the kinases Myt1 and Wee1.	Tyrosine	68-71	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	151-155
10601234-2	1999	In Xenopus egg extracts, the inhibitory phosphorylations of Cdc2 on Tyr-15 and Thr-14 are controlled by the phosphatase Cdc25 and the kinases Myt1 and Wee1.	Threonine	79-82	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	151-155
10072389-7	1999	We find that Xe-Wee1 tyrosine autophosphorylation positively regulates Xe-Wee1 and is only detected in the first 30 min of the first cell cycle.	Tyrosine	21-29	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	13-20
10072389-7	1999	We find that Xe-Wee1 tyrosine autophosphorylation positively regulates Xe-Wee1 and is only detected in the first 30 min of the first cell cycle.	Tyrosine	21-29	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	71-78
10072389-8	1999	The level and duration of Xe-Wee1 tyrosine phosphorylation is elevated significantly when the first cell cycle is elongated with nondegradable Mos.	Tyrosine	34-42	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	26-33
10072389-9	1999	Importantly, we show that the tyrosine phosphorylation of Xe-Wee1 is required for the Mos-mediated M-phase delay.	Tyrosine	30-38	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	58-65
7569953-3	1995	Although Wee1 has been identified as the kinase that phosphorylates tyrosine-15 in various organisms, the threonine-14-specific kinase has not been isolated.	Tyrosine	68-76	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	9-13
7569953-4	1995	A complementary DNA was cloned from Xenopus that encodes Myt1, a member of the Wee1 family that was discovered to phosphorylate Cdc2 efficiently on both threonine-14 and tyrosine-15.	Threonine	153-162	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	79-83
7569953-4	1995	A complementary DNA was cloned from Xenopus that encodes Myt1, a member of the Wee1 family that was discovered to phosphorylate Cdc2 efficiently on both threonine-14 and tyrosine-15.	Tyrosine	170-178	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	79-83
9486797-4	1998	A dominant negative form of Xe-wee1 (KM wee1) reduced the level cdc2 tyrosine phosphorylation and length of the first cycle.	Tyrosine	69-77	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	28-35
9486797-4	1998	A dominant negative form of Xe-wee1 (KM wee1) reduced the level cdc2 tyrosine phosphorylation and length of the first cycle.	Tyrosine	69-77	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	31-35
7749193-2	1995	The recombinant Xenopus Wee1 protein efficiently phosphorylates Cdc2 exclusively on Tyr-15 in a cyclin-dependent manner.	Tyrosine	84-87	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	24-28
7749193-3	1995	The addition of exogenous Wee1 protein to Xenopus cell cycle extracts results in a dose-dependent delay of mitotic initiation that is accompanied by enhanced tyrosine phosphorylation of Cdc2.	Tyrosine	158-166	WEE2 oocyte meiosis inhibiting kinase S homeolog	Xenopus laevis	26-30