PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
1831770-3	1991	The amino-terminal sequence analysis of the mature AGIF revealed that AGIF was produced as a precursor consisting of 199 amino acids and processed into a mature form of 178 amino acids by a cleavage between Ala(-1) and Pro(+1).	Alanine	207-210	interleukin 11	Homo sapiens	51-55
1831770-3	1991	The amino-terminal sequence analysis of the mature AGIF revealed that AGIF was produced as a precursor consisting of 199 amino acids and processed into a mature form of 178 amino acids by a cleavage between Ala(-1) and Pro(+1).	Alanine	207-210	interleukin 11	Homo sapiens	70-74
34624437-6	2022	The generation of sIL-11R and thus the initiation of IL-11 trans-signaling is mediated by proteolytic cleavage.	sil-11r	18-25	interleukin 11	Homo sapiens	53-58
34434930-8	2021	Our data shows MSU crystal but not UA enhances the decidualization response of endometrial stromal cells, via the upregulation of inflammatory genes such Ptgs2 and Il11.	Uric Acid	15-18	interleukin 11	Homo sapiens	164-168
34789212-2	2021	We had shown earlier that blocking TGF-beta receptor type I kinase with the inhibitor SB431542 abolished the expression of IL11 and other genes in human gingival fibroblasts exposed to the aqueous fraction of milk.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	86-94	interleukin 11	Homo sapiens	123-127
34789212-5	2021	Among the SB431542-dependent genes is IL11 but also cadherins, claudins, collagens, potassium channels, keratins, solute carrier family proteins, transcription factors, transmembrane proteins, tumor necrosis factor ligand superfamily members, and tetraspanin family members.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	10-18	interleukin 11	Homo sapiens	38-42
34789212-7	2021	In contrast, genistein and blocking phosphoinositide 3-kinases by wortmannin and LY294002 increased the milk-induced IL11 expression in gingival fibroblasts.	Genistein	13-22	interleukin 11	Homo sapiens	117-121
34789212-7	2021	In contrast, genistein and blocking phosphoinositide 3-kinases by wortmannin and LY294002 increased the milk-induced IL11 expression in gingival fibroblasts.	Wortmannin	66-76	interleukin 11	Homo sapiens	117-121
34789212-7	2021	In contrast, genistein and blocking phosphoinositide 3-kinases by wortmannin and LY294002 increased the milk-induced IL11 expression in gingival fibroblasts.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	81-89	interleukin 11	Homo sapiens	117-121
34933172-4	2022	Surface plasmon resonance spectroscopy revealed formation of calcium-dependent complexes between IL-11, OSM, CNTF, CT-1, and CLCF1 and distinct subsets of S100A1/A6/B/P proteins with equilibrium dissociation constants of 19 nM - 12 microM.	Calcium	61-68	interleukin 11	Homo sapiens	97-102
34673182-4	2021	Moreover, the significant decreases in GH production and secretion induced by DON were dose-dependent, accompanied by an increase of caspase 3, 8 and 9, IL-11, IL-lbeta and GHRH.	DONS	78-81	interleukin 11	Homo sapiens	153-158
34447675-10	2021	Conclusions: Our finding regarding AFB1 toxicity enhancement by an HBx-PXR-CYP3A4/ GSTM1-KRAS-IL11:IL11RA signaling axis provides a rational explanation for the synergistic effects of chemical carcinogens in HBV infection-associated hepatocarcinogenesis.	Aflatoxin B1	35-39	interleukin 11	Homo sapiens	94-98
34323400-6	2021	Moreover, MRI-1867 treatment abrogated bleomycin-induced increases in lung levels of the profibrotic interleukin-11 via iNOS inhibition and reversed mitochondrial dysfunction via CB1 R inhibition.	Bleomycin	39-48	interleukin 11	Homo sapiens	101-115
34108253-5	2021	IL11 secreted from APAP-damaged human and mouse hepatocytes triggered an autocrine loop of NADPH oxidase 4 (NOX4)-dependent cell death, which occurred downstream of APAP-initiated mitochondrial dysfunction.	Acetaminophen	165-169	interleukin 11	Homo sapiens	0-4
34175855-12	2022	Compared with n-DMSCs, the p-DMSCs showed increased secretion of IL-11, EGF, and SCF.	n-dmscs	14-21	interleukin 11	Homo sapiens	65-70
34175855-12	2022	Compared with n-DMSCs, the p-DMSCs showed increased secretion of IL-11, EGF, and SCF.	p-dmscs	27-34	interleukin 11	Homo sapiens	65-70
34108253-2	2021	In the mouse model of APAP-induced liver injury (AILI), interleukin 11 (IL11) is highly up-regulated and administration of recombinant human IL11 (rhIL11) has been shown to be protective.	Acetaminophen	22-26	interleukin 11	Homo sapiens	141-145
33562198-0	2021	Increased Interleukin-11 and Stress-Related Gene Expression in Human Endothelial and Bronchial Epithelial Cells Exposed to Silver Nanoparticles.	Silver	123-129	interleukin 11	Homo sapiens	10-24
34108253-5	2021	IL11 secreted from APAP-damaged human and mouse hepatocytes triggered an autocrine loop of NADPH oxidase 4 (NOX4)-dependent cell death, which occurred downstream of APAP-initiated mitochondrial dysfunction.	Acetaminophen	19-23	interleukin 11	Homo sapiens	0-4
35151984-7	2022	The groups treated with GnRHa exhibited a progressive and significant time-dependent decrease in the IL-6 and IL-11 mRNA.	gnrha	24-29	interleukin 11	Homo sapiens	110-115
35151984-11	2022	The results showed that ultra-long GnRHa administration can improve outcomes, especially after 3 cycles of GnRHa pretreatment, and endometrial receptivity through IL-6 and IL-11 expression levels of ESC regulated by the miR-124-3p for patients with HRT, who underwent FET cycles.	gnrha	35-40	interleukin 11	Homo sapiens	172-177
35603964-5	2022	By fusing the skin fibroblast membrane onto poly(lactic-co-glycolic) acid cores, these nanoparticles, termed fibroblast membrane-camouflaged nanoparticles (FNPs), are shown to effectively scavenge various profibrotic cytokines, including transforming growth factor-beta, interleukin (IL)-11, IL-13, and IL-17, thereby modulating the profibrotic microenvironment.	Polylactic Acid-Polyglycolic Acid Copolymer	44-73	interleukin 11	Homo sapiens	271-290
35351591-7	2022	Furthermore, DON increased NNMT to reduce pro-inflammatory cytokines, including interleukin (IL)-1beta, IL-11 and IL-6, and thus increased IGF-1 and cell viability, alleviating the cell growth inhibition induced by DON.	deoxynivalenol	13-16	interleukin 11	Homo sapiens	104-109
35365572-0	2022	Interleukin-11 drives human and mouse alcohol-related liver disease.	Alcohols	38-45	interleukin 11	Homo sapiens	0-14
6303628-3	1983	However, the isoelectrofocusing study with thin-layer polyacrylamide gels (PAGIF) as well as with agarose gels (AGIF) showed a distinctive difference.	polyacrylamide	54-68	interleukin 11	Homo sapiens	76-80
34054526-0	2021	Ameliorative Effects of Osthole on Experimental Renal Fibrosis in vivo and in vitro by Inhibiting IL-11/ERK1/2 Signaling.	osthol	24-31	interleukin 11	Homo sapiens	98-103
34054526-7	2021	After preliminarily confirming the antifibrogenic effects of osthole and the link between its antifibrogenic effects and the inhibition of IL-11/ERK1/2 signaling, we applied a direct IL-11-induced HK-2 cells fibrosis model to further explore the inhibitory effects of osthole on IL-11/ERK1/2 signaling pathway.	osthol	61-68	interleukin 11	Homo sapiens	183-188
34054526-7	2021	After preliminarily confirming the antifibrogenic effects of osthole and the link between its antifibrogenic effects and the inhibition of IL-11/ERK1/2 signaling, we applied a direct IL-11-induced HK-2 cells fibrosis model to further explore the inhibitory effects of osthole on IL-11/ERK1/2 signaling pathway.	osthol	61-68	interleukin 11	Homo sapiens	183-188
34054526-9	2021	More importantly, we found that IL-11/ERK1/2 signaling in UUO-induced renal fibrosis and TGF-beta-induced HK-2 cell model was obviously upregulated, and osthole treatment also significantly inhibited the abnormal IL-11/ERK1/2 signaling activation.	uuo	58-61	interleukin 11	Homo sapiens	32-37
34054526-9	2021	More importantly, we found that IL-11/ERK1/2 signaling in UUO-induced renal fibrosis and TGF-beta-induced HK-2 cell model was obviously upregulated, and osthole treatment also significantly inhibited the abnormal IL-11/ERK1/2 signaling activation.	osthol	153-160	interleukin 11	Homo sapiens	32-37
34054526-9	2021	More importantly, we found that IL-11/ERK1/2 signaling in UUO-induced renal fibrosis and TGF-beta-induced HK-2 cell model was obviously upregulated, and osthole treatment also significantly inhibited the abnormal IL-11/ERK1/2 signaling activation.	osthol	153-160	interleukin 11	Homo sapiens	213-218
33898438-4	2021	We found that prednisolone treatment reduced hESF cytokine expression (IL6, IL11, IL18, LIF, and LIFR) but had no effect on hESF expression or secretion of the classic markers of decidualization [prolactin (PRL) and IGFBP1].	Prednisolone	14-26	interleukin 11	Homo sapiens	76-80
33692217-7	2021	TANs and TAMs produced higher levels of oncostatin M and interleukin-11, respectively, in co-culture than in monoculture.	Tamoxifen	9-13	interleukin 11	Homo sapiens	57-71
34042220-0	2021	miR-10396b-3p inhibits mechanical stress-induced ligamentum flavum hypertrophy by targeting IL-11.	mir-10396b-3p	0-13	interleukin 11	Homo sapiens	92-97
34042220-8	2021	Luciferase reporter assay indicates that IL-11 is a direct target of miR-10396b-3p.	mir-10396b	69-79	interleukin 11	Homo sapiens	41-46
34042220-10	2021	Our results showed that overexpression of miR-10396b-3p suppresses MS-induced LFH by inhibiting collagen I and III via the inhibition of IL-11.	mir-10396b-3p	42-55	interleukin 11	Homo sapiens	137-142
3234387-1	1988	Using isoelectric focusing in thin-layer agarose gel (AGIF) with the narrow pH range of 4.5-5.4, a high resolution of esterase D (ESD) isozyme banding patterns has been achieved.	Sepharose	41-48	interleukin 11	Homo sapiens	54-58
34054526-12	2021	Moreover, it was observed that the IL-11/ERK1/2 inhibitor, U0126, partly blocked the antifibrogenic effects of osthole.	U 0126	59-64	interleukin 11	Homo sapiens	35-40
34054526-12	2021	Moreover, it was observed that the IL-11/ERK1/2 inhibitor, U0126, partly blocked the antifibrogenic effects of osthole.	osthol	111-118	interleukin 11	Homo sapiens	35-40
33562198-9	2021	Of note, IL-11 gene expression was particularly increased following the exposure of endothelial and epithelial cells to 5 nm silver NPs.	Silver	125-135	interleukin 11	Homo sapiens	9-14
33417258-7	2021	Our data provide the first complete transcriptome for aldosterone on a human renal cell line and identifies pro-inflammatory markers (IL6, IL11, CCL7, and CXCL8) as aldosterone-repressed genes.	Aldosterone	165-176	interleukin 11	Homo sapiens	139-143
33440877-4	2021	Exposing fibroblasts to the aqueous solution caused a TGF-beta receptor type I kinase-inhibitor SB431542-dependent increase in interleukin 11 (IL11), NADPH oxidase 4 (NOX4), and proteoglycan 4 (PRG4) expression.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	96-104	interleukin 11	Homo sapiens	127-141
33440877-4	2021	Exposing fibroblasts to the aqueous solution caused a TGF-beta receptor type I kinase-inhibitor SB431542-dependent increase in interleukin 11 (IL11), NADPH oxidase 4 (NOX4), and proteoglycan 4 (PRG4) expression.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	96-104	interleukin 11	Homo sapiens	143-147
31439713-9	2019	Furthermore, inflammatory cytokines (IL-8, IL-1beta and IL-11) were also up-regulated upon treatment with HCC approved kinase inhibitors Sorafenib and Regorafenib.	Sorafenib	137-146	interleukin 11	Homo sapiens	56-61
33042272-8	2020	Mechanistically, MITR counteracted MEF2A-induced transcriptional suppression of IL11, ultimately causing paclitaxel resistance.	Paclitaxel	105-115	interleukin 11	Homo sapiens	80-84
33042272-10	2020	Conclusion: Our in vitro and in vivo genetic and cellular analyses elucidated the pivotal role of MITR/MEF2A/IL11 axis in paclitaxel resistance and provided a novel therapeutic strategy for TNBC patients to overcome poor chemotherapy responses.	Paclitaxel	122-132	interleukin 11	Homo sapiens	109-113
32594141-9	2020	GW0742 treatment enhanced hormone-mediated ESC decidualization in vitro as manifested by upregulation of prolactin, IGFBP-1, IL-11 and VEGF secretion and also increased expression of ERalpha, PR-A and -B and Cx43.	GW0742	0-6	interleukin 11	Homo sapiens	125-130
32566012-8	2020	Furthermore, reverse transcription-quantitative PCR analysis revealed an increase in transcripts of the most upregulated genes in ASR 488-treated MIBC cells: CPEB1 (36-fold), IL11 (30-fold), SFN (20.12-fold) and CYP4F11 (15.8-fold).	asr	130-133	interleukin 11	Homo sapiens	175-179
31856924-3	2019	Using a novel FGFR1-selective agonist (F2 V2) generated by deleting the N-terminal 26 amino acids of FGF2 we demonstrate polarizing signal transduction to favor FGFR1 abrogates FGF mediated inhibition of myelination but retains its ability to induce expression of pro-myelinating and immunomodulatory factors that include Cd93, Lif, Il11, Hbegf, Cxcl1 and Timp1.	Fluorine	39-41	interleukin 11	Homo sapiens	333-337
32888128-12	2020	After treatment with Resveratrol, both IL-1beta mRNA and protein levels were reduced, while IL-11 protein levels showed any increase.	Resveratrol	21-32	interleukin 11	Homo sapiens	92-97
32888128-14	2020	Resveratrol can reverse the inflammatory effects of TNF-alpha by reducing IL-1beta and increasing IL-11 production.	Resveratrol	0-11	interleukin 11	Homo sapiens	98-103
31403827-6	2020	The hypoxia mimetic agent cobalt chloride induced upregulation of IL-11 and IL-11Ra in cultured Muller cells.	cobaltous chloride	26-41	interleukin 11	Homo sapiens	66-71
31439713-9	2019	Furthermore, inflammatory cytokines (IL-8, IL-1beta and IL-11) were also up-regulated upon treatment with HCC approved kinase inhibitors Sorafenib and Regorafenib.	regorafenib	151-162	interleukin 11	Homo sapiens	56-61
31412584-3	2019	Docetaxel or vinorelbine inhibits proliferation and stimulates the differentiation of breast preadipocytes, by increasing C/EBPalpha and PPARgamma expression and by downregulating tumor necrosis factor alpha (TNFalpha), interleukin 6 (IL-6), and IL-11 expression.	Docetaxel	0-9	interleukin 11	Homo sapiens	246-251
31283912-7	2019	Only JJN-3-derived EVs induced IL-11 secretion in osteoblast-like recipient cells.	jjn	5-8	interleukin 11	Homo sapiens	31-36
31502734-8	2019	Fewer numbers of glandular epithelial cells were observed to be positively stained with IL-11 antibody in labial glands from pSS patients than in healthy control patients.	pss	125-128	interleukin 11	Homo sapiens	88-93
31412584-3	2019	Docetaxel or vinorelbine inhibits proliferation and stimulates the differentiation of breast preadipocytes, by increasing C/EBPalpha and PPARgamma expression and by downregulating tumor necrosis factor alpha (TNFalpha), interleukin 6 (IL-6), and IL-11 expression.	Vinorelbine	13-24	interleukin 11	Homo sapiens	246-251
31217693-9	2019	There was a significant decrease in IL-11 levels in the other treatment group compared with the group receiving paclitaxel, docetaxel, gemcitabine, and vinorelbine in the first day following chemotherapy (P = .006).	Paclitaxel	112-122	interleukin 11	Homo sapiens	36-41
31299894-10	2019	As to IL-11, inhibitor of NF-kappaB (BAY 11-7082) can significantly down regulate the mRNA expression of IL-11.	3-(4-methylphenylsulfonyl)-2-propenenitrile	37-48	interleukin 11	Homo sapiens	6-11
31299894-10	2019	As to IL-11, inhibitor of NF-kappaB (BAY 11-7082) can significantly down regulate the mRNA expression of IL-11.	3-(4-methylphenylsulfonyl)-2-propenenitrile	37-48	interleukin 11	Homo sapiens	105-110
31217693-9	2019	There was a significant decrease in IL-11 levels in the other treatment group compared with the group receiving paclitaxel, docetaxel, gemcitabine, and vinorelbine in the first day following chemotherapy (P = .006).	gemcitabine	135-146	interleukin 11	Homo sapiens	36-41
31028903-5	2019	Exposure of these cells to lipogenic (insulin, glucose, fatty acids) and pro-inflammatory factors (IL-1beta, TNF-alpha, TGF-beta) resulted in a characteristic NASH response, as indicated by intracellular lipid accumulation, modulation of NASH-specific gene expression, increased caspase-3/7 activity and the expression and/or secretion of inflammatory markers, including CCL2, CCL5, CCL7, CCL8, CXCL5, CXCL8, IL1a, IL6 and IL11.	Fatty Acids	56-67	interleukin 11	Homo sapiens	423-427
30056070-9	2018	However, there was a suggestive evidence for an association of the length of a dinucleotide repeat in the IL11 promoter region with HSCR with an over-representation of >7 GT repeat subtypes (OR = 4.982 (1.448-17.040), p-value = 0.0111) in HSCR patients.	Dinucleoside Phosphates	79-91	interleukin 11	Homo sapiens	106-110
30736824-3	2019	Bazedoxifene, a third- generation selective estrogen modulator approved by the Food and Drug Administration (FDA), is a novel inhibitor of IL-11/GP130 signaling discovered by docking modeling.	bazedoxifene	0-12	interleukin 11	Homo sapiens	139-144
30736824-5	2019	RESULTS: Bazedoxifene inhibits phosphorylation of signal transducer and activator of transcription 3 (p-STAT3) and its nuclear translocation induced by IL-11 in colon cancer cells.	bazedoxifene	9-21	interleukin 11	Homo sapiens	152-157
30736824-10	2019	IL-11 can reduce the efficacy of oxaliplatin-mediated inhibition of cell viability.	Oxaliplatin	33-44	interleukin 11	Homo sapiens	0-5
30736824-13	2019	CONCLUSIONS: Taken together, these results support bazedoxifene as a novel and effective therapeutic agent targeting IL-11/GP130 signaling for human colorectal cancer therapy.	bazedoxifene	51-63	interleukin 11	Homo sapiens	117-122
31935737-0	2019	Assessment of CCL27 and IL-11 in Multiple Sclerosis Patients Treated with Interferon-beta and Glatiramer Acetate.	Acetates	105-112	interleukin 11	Homo sapiens	24-29
30885958-6	2019	Likewise, bazedoxifene treatment of human colon cancer cells harboring mutant APC did not reduce aberrant canonical WNT signaling, but suppressed IL11-dependent STAT3 signaling.	bazedoxifene	10-22	interleukin 11	Homo sapiens	146-150
30885958-7	2019	Our findings provide compelling proof of concept to support the repurposing of bazedoxifene for the treatment of gastrointestinal cancers in which IL11 plays a tumor-promoting role.	bazedoxifene	79-91	interleukin 11	Homo sapiens	147-151
30903857-14	2019	In conclusion, this study demonstrates the role of thrombin in regulating human EVT migration via IL-11 secretion.	EVT	80-83	interleukin 11	Homo sapiens	98-103
30572654-3	2018	We found that Ponatinib inhibits STAT3 activity driven by EGF/EGFR, IL-6/IL-6R and IL-11/IL-11R, three major ligand/receptor systems involved in CRC development and progression.	ponatinib	14-23	interleukin 11	Homo sapiens	83-88
29901200-0	2018	miR-23b inhibits proliferation of SMMC-7721 cells by directly targeting IL-11.	smmc	34-38	interleukin 11	Homo sapiens	72-77
30005986-3	2018	Modification of human interleukin-11 with chemically inert polyethylene glycol polymer (PEG) may extend the peripheral circulation half-life leading to an improved pharmacokinetic and pharmadynamic profile.	polyethylene glycol polymer	59-86	interleukin 11	Homo sapiens	22-36
30005986-3	2018	Modification of human interleukin-11 with chemically inert polyethylene glycol polymer (PEG) may extend the peripheral circulation half-life leading to an improved pharmacokinetic and pharmadynamic profile.	Polyethylene Glycols	88-91	interleukin 11	Homo sapiens	22-36
30375456-5	2018	Whole genome microarrays and RT-PCR together with the pharmacologic blocking of TGF-beta receptor type I kinase with SB431542 showed that ABL activates the TGF-beta target genes interleukin 11, proteoglycan 4, and NADPH oxidase 4.	lauric acid	138-141	interleukin 11	Homo sapiens	178-192
30293399-3	2018	The main treatments of CIT include transfusion of platelets, recombinant human thrombopoietin (rhTPO), and recombinant human interleukin-11 (rhIL-11).	cit	23-26	interleukin 11	Homo sapiens	125-139
30181697-4	2018	Result demonstrated that IL-8 and IL-11 expression were upregulated in LPA-treated MDA-MB-231 cells.	lysophosphatidic acid	71-74	interleukin 11	Homo sapiens	34-39
30181697-7	2018	In the case of PKC activation, it was observed that PKCdelta and PKCmu might regulate LPA-induced expression of IL-11 and IL-8, respectively, by using specific PKC subtype inhibitors.	lysophosphatidic acid	86-89	interleukin 11	Homo sapiens	112-117
30181697-9	2018	In conclusion, LPA induced the expression of osteolytic cytokines (IL-8 and IL-11) in breast cancer cells by involving different LPA receptors.	lysophosphatidic acid	15-18	interleukin 11	Homo sapiens	76-81
30197757-6	2018	IL-11 expression under various conditions, including hypoxia or treatment with phorbol 12-myristate 13-acetate or copper sulfate.	Tetradecanoylphorbol Acetate	79-110	interleukin 11	Homo sapiens	0-5
30197757-6	2018	IL-11 expression under various conditions, including hypoxia or treatment with phorbol 12-myristate 13-acetate or copper sulfate.	Copper Sulfate	114-128	interleukin 11	Homo sapiens	0-5
30197757-7	2018	Recombinant IL-11-induced phosphorylation of signal transducer and activator of transcription 3 at tyrosine 705 was reduced in a dose-dependent manner in HeLa cells.	Tyrosine	99-107	interleukin 11	Homo sapiens	12-17
30197757-8	2018	Cross-talk between Zac1, IL-11, p53, and suppressor of cytokine signaling 3 was differentially affected by copper sulfate, digoxin, and caffeine.	Copper Sulfate	107-121	interleukin 11	Homo sapiens	25-30
30197757-8	2018	Cross-talk between Zac1, IL-11, p53, and suppressor of cytokine signaling 3 was differentially affected by copper sulfate, digoxin, and caffeine.	Digoxin	123-130	interleukin 11	Homo sapiens	25-30
30197757-8	2018	Cross-talk between Zac1, IL-11, p53, and suppressor of cytokine signaling 3 was differentially affected by copper sulfate, digoxin, and caffeine.	Caffeine	136-144	interleukin 11	Homo sapiens	25-30
29662190-5	2018	Inhibition of JAK2 by LY2784544 or IL-11 by anti-IL-11 antibody overcomes the platinum resistance in vitro or in vivo.	LY2784544	22-31	interleukin 11	Homo sapiens	49-54
29662190-4	2018	Using quantitative high-throughput combinational screen (qHTCS) and genomic sequencing, we show that in platinum-resistant ovarian cancer elevated ROS levels sustain high level of IL-11 by stimulating FRA1-mediated IL-11 expression and increased IL-11 causes resistance to platinum drugs by constitutively activating JAK2-STAT5 via an autocrine mechanism.	Platinum	104-112	interleukin 11	Homo sapiens	180-185
29662190-5	2018	Inhibition of JAK2 by LY2784544 or IL-11 by anti-IL-11 antibody overcomes the platinum resistance in vitro or in vivo.	Platinum	78-86	interleukin 11	Homo sapiens	35-40
29662190-4	2018	Using quantitative high-throughput combinational screen (qHTCS) and genomic sequencing, we show that in platinum-resistant ovarian cancer elevated ROS levels sustain high level of IL-11 by stimulating FRA1-mediated IL-11 expression and increased IL-11 causes resistance to platinum drugs by constitutively activating JAK2-STAT5 via an autocrine mechanism.	Platinum	104-112	interleukin 11	Homo sapiens	215-220
29662190-4	2018	Using quantitative high-throughput combinational screen (qHTCS) and genomic sequencing, we show that in platinum-resistant ovarian cancer elevated ROS levels sustain high level of IL-11 by stimulating FRA1-mediated IL-11 expression and increased IL-11 causes resistance to platinum drugs by constitutively activating JAK2-STAT5 via an autocrine mechanism.	Platinum	104-112	interleukin 11	Homo sapiens	215-220
29662190-5	2018	Inhibition of JAK2 by LY2784544 or IL-11 by anti-IL-11 antibody overcomes the platinum resistance in vitro or in vivo.	Platinum	78-86	interleukin 11	Homo sapiens	49-54
29662190-4	2018	Using quantitative high-throughput combinational screen (qHTCS) and genomic sequencing, we show that in platinum-resistant ovarian cancer elevated ROS levels sustain high level of IL-11 by stimulating FRA1-mediated IL-11 expression and increased IL-11 causes resistance to platinum drugs by constitutively activating JAK2-STAT5 via an autocrine mechanism.	Reactive Oxygen Species	147-150	interleukin 11	Homo sapiens	180-185
29662190-7	2018	These findings not only identify a novel ROS-IL-11-JAK2-mediated platinum resistance mechanism but also provide a new strategy for using LY2784544- or IL-11-mediated immunotherapy to treat platinum-resistant ovarian cancer.	Reactive Oxygen Species	41-44	interleukin 11	Homo sapiens	45-50
29662190-4	2018	Using quantitative high-throughput combinational screen (qHTCS) and genomic sequencing, we show that in platinum-resistant ovarian cancer elevated ROS levels sustain high level of IL-11 by stimulating FRA1-mediated IL-11 expression and increased IL-11 causes resistance to platinum drugs by constitutively activating JAK2-STAT5 via an autocrine mechanism.	Reactive Oxygen Species	147-150	interleukin 11	Homo sapiens	215-220
29662190-4	2018	Using quantitative high-throughput combinational screen (qHTCS) and genomic sequencing, we show that in platinum-resistant ovarian cancer elevated ROS levels sustain high level of IL-11 by stimulating FRA1-mediated IL-11 expression and increased IL-11 causes resistance to platinum drugs by constitutively activating JAK2-STAT5 via an autocrine mechanism.	Reactive Oxygen Species	147-150	interleukin 11	Homo sapiens	215-220
29662190-4	2018	Using quantitative high-throughput combinational screen (qHTCS) and genomic sequencing, we show that in platinum-resistant ovarian cancer elevated ROS levels sustain high level of IL-11 by stimulating FRA1-mediated IL-11 expression and increased IL-11 causes resistance to platinum drugs by constitutively activating JAK2-STAT5 via an autocrine mechanism.	Platinum	273-281	interleukin 11	Homo sapiens	180-185
29662190-7	2018	These findings not only identify a novel ROS-IL-11-JAK2-mediated platinum resistance mechanism but also provide a new strategy for using LY2784544- or IL-11-mediated immunotherapy to treat platinum-resistant ovarian cancer.	Reactive Oxygen Species	41-44	interleukin 11	Homo sapiens	151-156
29662190-7	2018	These findings not only identify a novel ROS-IL-11-JAK2-mediated platinum resistance mechanism but also provide a new strategy for using LY2784544- or IL-11-mediated immunotherapy to treat platinum-resistant ovarian cancer.	Platinum	65-73	interleukin 11	Homo sapiens	45-50
29662190-7	2018	These findings not only identify a novel ROS-IL-11-JAK2-mediated platinum resistance mechanism but also provide a new strategy for using LY2784544- or IL-11-mediated immunotherapy to treat platinum-resistant ovarian cancer.	LY2784544	137-146	interleukin 11	Homo sapiens	45-50
29662190-7	2018	These findings not only identify a novel ROS-IL-11-JAK2-mediated platinum resistance mechanism but also provide a new strategy for using LY2784544- or IL-11-mediated immunotherapy to treat platinum-resistant ovarian cancer.	Platinum	189-197	interleukin 11	Homo sapiens	45-50
29662190-7	2018	These findings not only identify a novel ROS-IL-11-JAK2-mediated platinum resistance mechanism but also provide a new strategy for using LY2784544- or IL-11-mediated immunotherapy to treat platinum-resistant ovarian cancer.	Platinum	189-197	interleukin 11	Homo sapiens	151-156
29492387-10	2018	Although there were no significant differences in any of the baseline-measured values between the two groups, left ventricular developed pressure (LVDP) and changes in left ventricular pressures (dP/dt) were significantly higher in the IL-11 group at 120-minute reperfusion.	lvdp	147-151	interleukin 11	Homo sapiens	236-241
29555322-9	2018	In addition, the plasma IL-11, IL-17 and IFN-gamma were significantly higher in acute TAD patients than in NAD patients, and the correlation analysis showed that IL-11 levels were positively correlated with levels of IFN-gamma, IL-17, glucose, systolic blood pressure, diastolic blood pressure, white blood cells, C-reactive proteins and D-dimers.	Glucose	235-242	interleukin 11	Homo sapiens	162-167
29237553-8	2018	However, IL-11 R112H fails to support the survival of osteoclast progenitor cells and is less thermally stable, which is caused by the loss of the positive charge on the protein surface since protonation of the histidine side chain recovers stability.	Histidine	211-220	interleukin 11	Homo sapiens	9-14
29397850-0	2018	[Efficacy of Recombinant Human Thrombopoietin and Recombinant Human Interleukin 11 for Treatment of Chemotherapy Indu-ced Thrombocytopenia in Acute Myeloid Leukaemia Patients].	indu	113-117	interleukin 11	Homo sapiens	68-82
29397850-0	2018	[Efficacy of Recombinant Human Thrombopoietin and Recombinant Human Interleukin 11 for Treatment of Chemotherapy Indu-ced Thrombocytopenia in Acute Myeloid Leukaemia Patients].	Cephradine	118-121	interleukin 11	Homo sapiens	68-82
29977885-15	2018	The levels of ROR-gammat (retinoic acid receptor-related orphan nuclear receptor gamma), FoxP3 (forkhead transcription factor), IL-10 (interleukin-11) and TGF-beta (transforming growth factor beta) were lower in the CG group than in the AG group (P < 0.05).	cysteinylglycine	216-218	interleukin 11	Homo sapiens	135-149
28462005-7	2017	RESULTS: We found that 5-aza enhanced TGF-beta1-induced interleukin-11 (IL11) expression in gingival fibroblasts 2.37-fold (P=0.008).	Azacitidine	23-28	interleukin 11	Homo sapiens	56-70
29533934-10	2018	CONCLUSION: Our results show that the two N-glycosylation sites differentially influence stability and proteolytic processing of the IL-11R, but that N-linked glycosylation is not a prerequisite for IL-11 signaling.	Nitrogen	2-3	interleukin 11	Homo sapiens	133-138
28390266-8	2017	Patients with suboptimal serum 25-OHD had higher IL-6, 8 and 18 (p=0.003, 0.010 and 0.002 respectively) and lower levels of IL-11 (p=0.005).	25-ohd	31-37	interleukin 11	Homo sapiens	124-129
29550807-4	2018	METHODS: Cell proliferation in response to IL-11 was determined by colony formation, BrdU incorporation and MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay.	3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium	113-201	interleukin 11	Homo sapiens	43-48
29550807-15	2018	Deferoxamine (DFX) or dimethyloxalylglycine (DMOG) induced hypoxia-inducible factor 1-alpha (HIF1alpha) upregulation, which enhanced IL-11 expression in NSCLC cells.	Deferoxamine	0-12	interleukin 11	Homo sapiens	133-138
29550807-15	2018	Deferoxamine (DFX) or dimethyloxalylglycine (DMOG) induced hypoxia-inducible factor 1-alpha (HIF1alpha) upregulation, which enhanced IL-11 expression in NSCLC cells.	Deferoxamine	14-17	interleukin 11	Homo sapiens	133-138
29550807-15	2018	Deferoxamine (DFX) or dimethyloxalylglycine (DMOG) induced hypoxia-inducible factor 1-alpha (HIF1alpha) upregulation, which enhanced IL-11 expression in NSCLC cells.	oxalylglycine	22-43	interleukin 11	Homo sapiens	133-138
29550807-15	2018	Deferoxamine (DFX) or dimethyloxalylglycine (DMOG) induced hypoxia-inducible factor 1-alpha (HIF1alpha) upregulation, which enhanced IL-11 expression in NSCLC cells.	oxalylglycine	45-49	interleukin 11	Homo sapiens	133-138
28735867-3	2017	The liberated soluble IL-11R (sIL-11R) ectodomain can bind its ligand, and the resulting IL-11/sIL-11R complex can activate cells that do not express the IL-11R (trans-signaling).	sil-11r	30-37	interleukin 11	Homo sapiens	22-27
28735867-3	2017	The liberated soluble IL-11R (sIL-11R) ectodomain can bind its ligand, and the resulting IL-11/sIL-11R complex can activate cells that do not express the IL-11R (trans-signaling).	sil-11r	95-102	interleukin 11	Homo sapiens	22-27
28647515-11	2017	The enhanced expression of LIF, IL-11, integrin alphaV, and HOXA10 induced by AglyMax-Sup was abolished by the ER antagonist fulvestrant and the ERK inhibitor PD98059.	aglymax-sup	78-89	interleukin 11	Homo sapiens	32-37
28647515-11	2017	The enhanced expression of LIF, IL-11, integrin alphaV, and HOXA10 induced by AglyMax-Sup was abolished by the ER antagonist fulvestrant and the ERK inhibitor PD98059.	Fulvestrant	125-136	interleukin 11	Homo sapiens	32-37
28647515-11	2017	The enhanced expression of LIF, IL-11, integrin alphaV, and HOXA10 induced by AglyMax-Sup was abolished by the ER antagonist fulvestrant and the ERK inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	159-166	interleukin 11	Homo sapiens	32-37
28462005-13	2017	CONCLUSIONS: These in vitro data suggest that the inhibition of DNA methylation by 5-aza supports TGF-beta-induced IL11 expression in gingival fibroblasts.	Azacitidine	83-88	interleukin 11	Homo sapiens	115-119
28462005-7	2017	RESULTS: We found that 5-aza enhanced TGF-beta1-induced interleukin-11 (IL11) expression in gingival fibroblasts 2.37-fold (P=0.008).	Azacitidine	23-28	interleukin 11	Homo sapiens	72-76
28462005-9	2017	Consistent with this, 5-aza caused demethylation of the IL11 gene commonly next to a guanosine (CpG) island in gingival fibroblasts.	Azacitidine	22-27	interleukin 11	Homo sapiens	56-60
28462005-9	2017	Consistent with this, 5-aza caused demethylation of the IL11 gene commonly next to a guanosine (CpG) island in gingival fibroblasts.	Guanosine	85-94	interleukin 11	Homo sapiens	56-60
28462005-10	2017	The TGF-beta type I receptor kinase inhibitor SB431542 impeded the changes in IL11 expression, indicating that the effects of 5-aza require TGF-beta signaling.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	46-54	interleukin 11	Homo sapiens	78-82
28462005-10	2017	The TGF-beta type I receptor kinase inhibitor SB431542 impeded the changes in IL11 expression, indicating that the effects of 5-aza require TGF-beta signaling.	Azacitidine	126-131	interleukin 11	Homo sapiens	78-82
26818588-8	2017	RESULTS: Incubation of collagen membranes with BCM for at least one minute caused fibroblasts to decrease the expression of adrenomedullin and pentraxin 3, and to increase the expression of interleukin 11 and proteoglycan 4.	bcm	47-50	interleukin 11	Homo sapiens	190-204
27884519-4	2017	Modified vectors were constructed by introducing N- or O-glycosylation site on the region of hIL-11 that does not belong to the core alpha-helical motif based on the predicted secondary structure.	Nitrogen	49-50	interleukin 11	Homo sapiens	93-99
26726132-4	2017	Strict calcium dependence of this interaction suggests a possibility of IL-11 interaction with other calcium sensor proteins.	Calcium	7-14	interleukin 11	Homo sapiens	72-77
26726132-5	2017	Here we probed specificity of IL-11 to calcium-binding proteins of various types: calcium sensors of the EF-hand family (calmodulin, S100B and neuronal calcium sensors: recoverin, NCS-1, GCAP-1, GCAP-2), calcium buffers of the EF-hand family (S100G, oncomodulin), and a non-EF-hand calcium buffer (alpha-lactalbumin).	Calcium	82-89	interleukin 11	Homo sapiens	30-35
27396368-7	2017	IL-11 was significantly lower in the HCV-ITP group (10.829 vs. 15.042).	Inosine Triphosphate	41-44	interleukin 11	Homo sapiens	0-5
26726132-4	2017	Strict calcium dependence of this interaction suggests a possibility of IL-11 interaction with other calcium sensor proteins.	Calcium	101-108	interleukin 11	Homo sapiens	72-77
26726132-5	2017	Here we probed specificity of IL-11 to calcium-binding proteins of various types: calcium sensors of the EF-hand family (calmodulin, S100B and neuronal calcium sensors: recoverin, NCS-1, GCAP-1, GCAP-2), calcium buffers of the EF-hand family (S100G, oncomodulin), and a non-EF-hand calcium buffer (alpha-lactalbumin).	Calcium	82-89	interleukin 11	Homo sapiens	30-35
26726132-5	2017	Here we probed specificity of IL-11 to calcium-binding proteins of various types: calcium sensors of the EF-hand family (calmodulin, S100B and neuronal calcium sensors: recoverin, NCS-1, GCAP-1, GCAP-2), calcium buffers of the EF-hand family (S100G, oncomodulin), and a non-EF-hand calcium buffer (alpha-lactalbumin).	Calcium	82-89	interleukin 11	Homo sapiens	30-35
26726132-5	2017	Here we probed specificity of IL-11 to calcium-binding proteins of various types: calcium sensors of the EF-hand family (calmodulin, S100B and neuronal calcium sensors: recoverin, NCS-1, GCAP-1, GCAP-2), calcium buffers of the EF-hand family (S100G, oncomodulin), and a non-EF-hand calcium buffer (alpha-lactalbumin).	Calcium	39-46	interleukin 11	Homo sapiens	30-35
26726132-6	2017	A specific subset of the calcium sensor proteins (calmodulin, S100B, NCS-1, GCAP-1/2) exhibits metal-dependent binding of IL-11 with dissociation constants of 1-19 muM.	Calcium	25-32	interleukin 11	Homo sapiens	122-127
26726132-5	2017	Here we probed specificity of IL-11 to calcium-binding proteins of various types: calcium sensors of the EF-hand family (calmodulin, S100B and neuronal calcium sensors: recoverin, NCS-1, GCAP-1, GCAP-2), calcium buffers of the EF-hand family (S100G, oncomodulin), and a non-EF-hand calcium buffer (alpha-lactalbumin).	Calcium	82-89	interleukin 11	Homo sapiens	30-35
26726132-6	2017	A specific subset of the calcium sensor proteins (calmodulin, S100B, NCS-1, GCAP-1/2) exhibits metal-dependent binding of IL-11 with dissociation constants of 1-19 muM.	Metals	95-100	interleukin 11	Homo sapiens	122-127
27487122-4	2016	Here, we found that cobalt chloride (a hypoxia mimetic) promoted IL-11 expression via HIF-1alpha activation.	cobaltous chloride	20-35	interleukin 11	Homo sapiens	65-70
26726132-8	2017	Replacements of the respective S100P residues by alanine drastically decrease its affinity to IL-11, suggesting their involvement into the association process.	Alanine	49-56	interleukin 11	Homo sapiens	94-99
27693781-0	2016	Inorganic polyphosphate triggers upregulation of interleukin 11 in human osteoblast-like SaOS-2 cells.	inorganic polyphosphate	0-23	interleukin 11	Homo sapiens	49-63
27922075-0	2016	Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway.	Cisplatin	43-52	interleukin 11	Homo sapiens	112-117
27922075-4	2016	Meanwhile, Interleukin-11(IL-11) was significantly up-regulated in the CAF stimulated by cisplatin.	Cisplatin	89-98	interleukin 11	Homo sapiens	11-25
27922075-4	2016	Meanwhile, Interleukin-11(IL-11) was significantly up-regulated in the CAF stimulated by cisplatin.	Cisplatin	89-98	interleukin 11	Homo sapiens	26-31
27922075-5	2016	As confirmed in lung adenocarcinoma cells in vivo and in vitro, IL-11 could protect cancer cells from cisplatin-induced apoptosis and thus promote their chemoresistance.	Cisplatin	102-111	interleukin 11	Homo sapiens	64-69
27535971-5	2016	Bazedoxifene also inhibited STAT3 phosphorylation induced by IL6 and IL11, but not by OSM or STAT1 phosphorylation induced by INFgamma in pancreatic cancer cells, suggesting that Bazedoxifene inhibits the GP130/STAT3 pathway mediated by IL6 and IL11.	bazedoxifene	0-12	interleukin 11	Homo sapiens	69-73
27011369-6	2016	Unfractionated heparin as well as tinzaparin attenuated the IL-1beta-mediated induction of IL-6, IL-11, and LIF on protein and messenger RNA (mRNA) levels.	Heparin	15-22	interleukin 11	Homo sapiens	97-102
27334537-8	2016	A specific subset of the calcium sensor proteins (calmodulin, S100P, S100B, NCS-1, GCAP-1/2) exhibits metal-dependent binding of IL-11 with dissociation constants in a range of 1-19 muM, and the structural features of their hinge regions likely ensure selectivity and calcium sensitivity of IL-11 binding to the EF-hand proteins studied.	Calcium	25-32	interleukin 11	Homo sapiens	129-134
27334537-8	2016	A specific subset of the calcium sensor proteins (calmodulin, S100P, S100B, NCS-1, GCAP-1/2) exhibits metal-dependent binding of IL-11 with dissociation constants in a range of 1-19 muM, and the structural features of their hinge regions likely ensure selectivity and calcium sensitivity of IL-11 binding to the EF-hand proteins studied.	Calcium	25-32	interleukin 11	Homo sapiens	291-296
27334537-8	2016	A specific subset of the calcium sensor proteins (calmodulin, S100P, S100B, NCS-1, GCAP-1/2) exhibits metal-dependent binding of IL-11 with dissociation constants in a range of 1-19 muM, and the structural features of their hinge regions likely ensure selectivity and calcium sensitivity of IL-11 binding to the EF-hand proteins studied.	Metals	102-107	interleukin 11	Homo sapiens	129-134
27334537-8	2016	A specific subset of the calcium sensor proteins (calmodulin, S100P, S100B, NCS-1, GCAP-1/2) exhibits metal-dependent binding of IL-11 with dissociation constants in a range of 1-19 muM, and the structural features of their hinge regions likely ensure selectivity and calcium sensitivity of IL-11 binding to the EF-hand proteins studied.	Metals	102-107	interleukin 11	Homo sapiens	291-296
27334537-8	2016	A specific subset of the calcium sensor proteins (calmodulin, S100P, S100B, NCS-1, GCAP-1/2) exhibits metal-dependent binding of IL-11 with dissociation constants in a range of 1-19 muM, and the structural features of their hinge regions likely ensure selectivity and calcium sensitivity of IL-11 binding to the EF-hand proteins studied.	Calcium	268-275	interleukin 11	Homo sapiens	129-134
27334537-8	2016	A specific subset of the calcium sensor proteins (calmodulin, S100P, S100B, NCS-1, GCAP-1/2) exhibits metal-dependent binding of IL-11 with dissociation constants in a range of 1-19 muM, and the structural features of their hinge regions likely ensure selectivity and calcium sensitivity of IL-11 binding to the EF-hand proteins studied.	Calcium	268-275	interleukin 11	Homo sapiens	291-296
27011369-6	2016	Unfractionated heparin as well as tinzaparin attenuated the IL-1beta-mediated induction of IL-6, IL-11, and LIF on protein and messenger RNA (mRNA) levels.	Tinzaparin	34-44	interleukin 11	Homo sapiens	97-102
26950201-4	2016	We demonstrated that TSH-induced up-regulation of IL-11 is primarily mediated via the Gs pathway as IL-11 was up-regulated by forskolin (FSK), an adenylyl cyclase activator, and inhibited by protein kinase A inhibitor H-89 and by silencing of Galphas by small interfering RNA.	Thyrotropin	21-24	interleukin 11	Homo sapiens	50-55
26950201-4	2016	We demonstrated that TSH-induced up-regulation of IL-11 is primarily mediated via the Gs pathway as IL-11 was up-regulated by forskolin (FSK), an adenylyl cyclase activator, and inhibited by protein kinase A inhibitor H-89 and by silencing of Galphas by small interfering RNA.	Thyrotropin	21-24	interleukin 11	Homo sapiens	100-105
26950201-4	2016	We demonstrated that TSH-induced up-regulation of IL-11 is primarily mediated via the Gs pathway as IL-11 was up-regulated by forskolin (FSK), an adenylyl cyclase activator, and inhibited by protein kinase A inhibitor H-89 and by silencing of Galphas by small interfering RNA.	Colforsin	126-135	interleukin 11	Homo sapiens	50-55
26950201-4	2016	We demonstrated that TSH-induced up-regulation of IL-11 is primarily mediated via the Gs pathway as IL-11 was up-regulated by forskolin (FSK), an adenylyl cyclase activator, and inhibited by protein kinase A inhibitor H-89 and by silencing of Galphas by small interfering RNA.	Colforsin	126-135	interleukin 11	Homo sapiens	100-105
26950201-4	2016	We demonstrated that TSH-induced up-regulation of IL-11 is primarily mediated via the Gs pathway as IL-11 was up-regulated by forskolin (FSK), an adenylyl cyclase activator, and inhibited by protein kinase A inhibitor H-89 and by silencing of Galphas by small interfering RNA.	Colforsin	137-140	interleukin 11	Homo sapiens	50-55
26950201-4	2016	We demonstrated that TSH-induced up-regulation of IL-11 is primarily mediated via the Gs pathway as IL-11 was up-regulated by forskolin (FSK), an adenylyl cyclase activator, and inhibited by protein kinase A inhibitor H-89 and by silencing of Galphas by small interfering RNA.	Colforsin	137-140	interleukin 11	Homo sapiens	100-105
26950201-4	2016	We demonstrated that TSH-induced up-regulation of IL-11 is primarily mediated via the Gs pathway as IL-11 was up-regulated by forskolin (FSK), an adenylyl cyclase activator, and inhibited by protein kinase A inhibitor H-89 and by silencing of Galphas by small interfering RNA.	galphas	243-250	interleukin 11	Homo sapiens	50-55
26950201-4	2016	We demonstrated that TSH-induced up-regulation of IL-11 is primarily mediated via the Gs pathway as IL-11 was up-regulated by forskolin (FSK), an adenylyl cyclase activator, and inhibited by protein kinase A inhibitor H-89 and by silencing of Galphas by small interfering RNA.	galphas	243-250	interleukin 11	Homo sapiens	100-105
26947914-5	2016	We found that cAMP-PKA pathway regulates the expression of LINC473 through IL-11-mediated STAT3 phosphorylation.	Cyclic AMP	14-18	interleukin 11	Homo sapiens	75-80
27079437-4	2016	Expression of interleukin-11, chemokine (C-X-C motif) ligand 1 (CXCL1), CXCL2, and CXCL5, which play tumor-promoting roles through a variety of mechanisms, is induced in a COX-2/PGE2 pathway-dependent manner in both human and mouse gastric tumors.	Dinoprostone	178-182	interleukin 11	Homo sapiens	14-28
26925632-1	2016	OBJECTIVE: to investigate the effect and side effects of recombinant human interleukin - 11 (rhIL - 11, in Chinese Juheli, produced by Qi Lu Biotechnology CO., LTD) in the second prevention of chemotherapy induced thrombocytopenia (CIT).	cit	232-235	interleukin 11	Homo sapiens	75-91
26857227-10	2016	We showed that several immunoregulatory cytokines and factors might be potentially involved in FSK-MSC immunomodulation with particular attention to hepatocyte growth factor and interleukin-11.	fsk	95-98	interleukin 11	Homo sapiens	178-192
26551460-3	2015	Recombinant forms of IL-11 and S100P interact with each other under physiological level of calcium ions.	Calcium	91-98	interleukin 11	Homo sapiens	21-26
26655736-3	2015	Interleukin-11 (IL11) impedes human EVT invasion in vitro and is elevated in PE decidua in women.	EVT	36-39	interleukin 11	Homo sapiens	0-14
26655736-3	2015	Interleukin-11 (IL11) impedes human EVT invasion in vitro and is elevated in PE decidua in women.	EVT	36-39	interleukin 11	Homo sapiens	16-20
24037316-5	2013	RESULTS: Isoflurane increased IL-11 synthesis in human (approximately 300-500% increase, N = 6) and mouse (23 +- 4 [mean +- SD] fold over carrier gas group, N = 4) proximal tubule cells that were attenuated by a TGF-beta1-neutralizing antibody.	Isoflurane	9-19	interleukin 11	Homo sapiens	30-35
26528857-8	2015	In line with the above findings, treatment with either IL-3 or IL-6 or IL-11 decreased the chemosensitivity to docetaxel while treatment with either IL-10 or IL-24 increased the sensitivity of docetaxel chemotherapy.	Docetaxel	111-120	interleukin 11	Homo sapiens	71-76
25545915-5	2014	The antagonistic effects of bornyl acetate on IL-1beta induced targets MMP-1 and MMP-13 were diminished by IL-11 knockdown.	bornyl acetate	28-42	interleukin 11	Homo sapiens	107-112
25545915-6	2014	Mechanistically, our results indicated that bornyl acetate significantly elevates the expression of AP-1 component c-fos, which may influence gross AP-1 activity and initial the transcription of IL-11.	bornyl acetate	44-58	interleukin 11	Homo sapiens	195-200
25197981-8	2014	The MAPK inhibitors SB203580 and U0126 lowered the impact of Emdogain on IL-11 expression.	SB 203580	20-28	interleukin 11	Homo sapiens	73-78
25197981-8	2014	The MAPK inhibitors SB203580 and U0126 lowered the impact of Emdogain on IL-11 expression.	U 0126	33-38	interleukin 11	Homo sapiens	73-78
24519625-0	2014	Prostaglandin F2alpha inhibits adipogenesis via an autocrine-mediated interleukin-11/glycoprotein 130/STAT1-dependent signaling cascade.	Dinoprost	0-21	interleukin 11	Homo sapiens	70-84
24519625-4	2014	We now report that the IL-11 cytokine, a member of the gp130 cytokine co-receptor-related family, is a downstream transcriptional target of this pathway in 3T3-L1 preadipocytes and is actively secreted in differentiating cells in response to PGF2alpha stimulation.	Dinoprost	242-251	interleukin 11	Homo sapiens	23-28
24519625-5	2014	Using a combined shRNA and dominant-negative receptor mutant approach, we provide evidence that IL-11/gp130-signaling is required to mediate the inhibitory effects of PGF2alpha on adipogenesis.	Dinoprost	167-176	interleukin 11	Homo sapiens	96-101
24519625-8	2014	Collectively, our findings support a model in which PGF2alpha inhibits adipocyte differentiation by means of an IL-11 mediated autocrine negative feedback loop, that acts via gp130 to block adipogenesis through the essential actions of the STAT1 transcription factor.	Dinoprost	52-61	interleukin 11	Homo sapiens	112-117
26419927-7	2015	RESULTS: FTY-P induced leukemia inhibitory factor (LIF), interleukin 11 (IL11), and heparin-binding EGF-like growth factor (HBEGF) mRNA, as well as secretion of LIF and IL11 protein.	FTY 720P	9-14	interleukin 11	Homo sapiens	57-71
26419927-7	2015	RESULTS: FTY-P induced leukemia inhibitory factor (LIF), interleukin 11 (IL11), and heparin-binding EGF-like growth factor (HBEGF) mRNA, as well as secretion of LIF and IL11 protein.	FTY 720P	9-14	interleukin 11	Homo sapiens	73-77
26419927-7	2015	RESULTS: FTY-P induced leukemia inhibitory factor (LIF), interleukin 11 (IL11), and heparin-binding EGF-like growth factor (HBEGF) mRNA, as well as secretion of LIF and IL11 protein.	FTY 720P	9-14	interleukin 11	Homo sapiens	169-173
26419927-9	2015	In the presence of this key inflammatory cytokine, FTY-P synergistically induced LIF, HBEGF, and IL11 mRNA, as well as secretion of LIF and IL11 protein.	FTY 720P	51-56	interleukin 11	Homo sapiens	97-101
26419927-9	2015	In the presence of this key inflammatory cytokine, FTY-P synergistically induced LIF, HBEGF, and IL11 mRNA, as well as secretion of LIF and IL11 protein.	FTY 720P	51-56	interleukin 11	Homo sapiens	140-144
26419927-14	2015	CONCLUSIONS: We identified effects of FTY-P on astrocytes, namely induction of neurotrophic mediators (LIF, HBEGF, and IL11) and inhibition of TNF-induced inflammatory genes (CXCL10, BAFF, MX1, and OAS2).	FTY 720P	38-43	interleukin 11	Homo sapiens	119-123
26284317-6	2015	Incubation of bone chips with 0.2% chlorhexidine, followed by vigorously washing resulted in a BCM with even higher expression of IL11, PRG4 and NOX4.	Chlorhexidine	35-48	interleukin 11	Homo sapiens	130-134
26284317-8	2015	Chlorhexidine alone, at low concentrations, increased IL11, PRG4 and NOX4 expression, independent of the TGF-beta receptor I kinase activity.	Chlorhexidine	0-13	interleukin 11	Homo sapiens	54-58
24633490-7	2015	Transcriptional stimulations by IL-11 were partially inhibited in the constructs that included 2-bp mutations in the cAMP response element 1 (CRE1, -72 to -79) and CRE2 (-667 to -674).	Cyclic AMP	117-121	interleukin 11	Homo sapiens	32-37
25545915-0	2014	Bornyl acetate has an anti-inflammatory effect in human chondrocytes via induction of IL-11.	bornyl acetate	0-14	interleukin 11	Homo sapiens	86-91
25545915-3	2014	In this study, we found that bornyl acetate elevates the expression of IL-11 at both the mRNA and protein levels.	bornyl acetate	29-43	interleukin 11	Homo sapiens	71-76
24823634-2	2014	In this issue of Cancer Cell, Yuan and colleagues discover a novel TGF-beta-induced lncRNA, lncRNA-ATB, which stimulates EMT through sequestering miR-200s and facilitates colonization by stabilizing IL-11 mRNA, thus promoting both early and late steps of cancer metastasis.	4-anisyltetrazolium blue	99-102	interleukin 11	Homo sapiens	199-204
24635366-9	2014	RESULTS: Thirteen potentially functional IL-11 gene variants, the G to A transversions at the position 3651 (G3651A) leading to the arginin to histidin exchange on the position 113 (R113H) were detected in the group of infertile women.	Arginine	132-139	interleukin 11	Homo sapiens	41-46
24635366-9	2014	RESULTS: Thirteen potentially functional IL-11 gene variants, the G to A transversions at the position 3651 (G3651A) leading to the arginin to histidin exchange on the position 113 (R113H) were detected in the group of infertile women.	Histidine	143-151	interleukin 11	Homo sapiens	41-46
24817287-1	2014	OBJECTIVE: To compare the effects of the pretreatment and treatment with recombinant human interleukin-11 (rhIL-11) on acute liver failure induced by D-galactosamine (D-GalN).	Galactosamine	150-165	interleukin 11	Homo sapiens	91-105
23142150-3	2013	In particular, protein levels of Tumor Necrosis Factor (TNF) and the SNPs rs1126757 in interleukin-11 (IL11), and rs7801617 in interleukin-6 (IL6), have previously been implicated in the clinical response to the selective serotonin reuptake inhibitor (SSRI) antidepressant escitalopram.	Serotonin	222-231	interleukin 11	Homo sapiens	87-101
24036113-11	2013	Together, our results suggest a two-step mechanism, whereby LfcinB induces TIMP-1 through an IL-11-dependent pathway involving transcription factor AP-1 and STAT3.	LFcinB	60-66	interleukin 11	Homo sapiens	93-98
23813214-4	2013	Treatment of human proximal tubule epithelial (HK-2) cells with a selective A1 adenosine receptor agonist, chloro-N(6)-cyclopentyladenosine (CCPA), induced the expression of IL-11 mRNA and protein in an extracellular signal-regulated kinase-dependent manner, and administration of CCPA in mice induced renal synthesis of IL-11.	chloro-n(6)-cyclopentyladenosine	107-139	interleukin 11	Homo sapiens	174-179
23813214-4	2013	Treatment of human proximal tubule epithelial (HK-2) cells with a selective A1 adenosine receptor agonist, chloro-N(6)-cyclopentyladenosine (CCPA), induced the expression of IL-11 mRNA and protein in an extracellular signal-regulated kinase-dependent manner, and administration of CCPA in mice induced renal synthesis of IL-11.	2-chloro-N(6)cyclopentyladenosine	141-145	interleukin 11	Homo sapiens	174-179
23813214-4	2013	Treatment of human proximal tubule epithelial (HK-2) cells with a selective A1 adenosine receptor agonist, chloro-N(6)-cyclopentyladenosine (CCPA), induced the expression of IL-11 mRNA and protein in an extracellular signal-regulated kinase-dependent manner, and administration of CCPA in mice induced renal synthesis of IL-11.	2-chloro-N(6)cyclopentyladenosine	281-285	interleukin 11	Homo sapiens	174-179
24273488-7	2013	CONCLUSION: Heparin can significantly enhance the stimulating effects of a combination of TPO, SCF, FL, IL-6, and IL-11 supplemented with autologous serum on CFU-MK, MK, and platelet production from CB CD34+ cells.	Heparin	12-19	interleukin 11	Homo sapiens	114-119
23142150-3	2013	In particular, protein levels of Tumor Necrosis Factor (TNF) and the SNPs rs1126757 in interleukin-11 (IL11), and rs7801617 in interleukin-6 (IL6), have previously been implicated in the clinical response to the selective serotonin reuptake inhibitor (SSRI) antidepressant escitalopram.	Citalopram	273-285	interleukin 11	Homo sapiens	87-101
23142150-6	2013	Binary logistic regressions revealed significant expression differences at baseline between responders and non-responders in TNF, and after escitalopram treatment in TNF and IL11.	Citalopram	140-152	interleukin 11	Homo sapiens	174-178
22151118-10	2012	One millimolar melatonin induced a reduction in TNF-alpha, IL-6, and IL-11 mRNA expression in MCF-7 and 3T3-L1 cells.	Melatonin	15-24	interleukin 11	Homo sapiens	69-74
23813018-6	2013	Serum level and mRNA expression of IL-11 in the MBC-B group were significantly higher than those in the PBC group.	potassium bicarbonate	104-107	interleukin 11	Homo sapiens	35-40
23813018-7	2013	IL-11 immunohistochemical staining showed that the percentage of positively stained cells in the MBC-B group (57.5 %) was significantly higher than that in the PBC group (14.29 %).	potassium bicarbonate	160-163	interleukin 11	Homo sapiens	0-5
22826953-4	2012	After purification with Ni-NTA affinity chromatography and refolding with renaturation buffer, the purity of the target hrIL-11 protein reached 95% and its biology activity was 1 x 10(6) IU/mg, determined by stimulating the proliferation of T1165, which facilitates further researches into effects of IL-11 on platelet proliferation and other function.	ni-nta	24-30	interleukin 11	Homo sapiens	122-127
22522458-5	2012	We subsequently showed how heparin and a high-molecular-weight Escherichia coli K5-derived heparin-like polysaccharide (K5-NSOS) inhibited TGF-beta-induced IL-11 production in MDA-MB-231(SA) cells.	Heparin	27-34	interleukin 11	Homo sapiens	156-161
22522458-5	2012	We subsequently showed how heparin and a high-molecular-weight Escherichia coli K5-derived heparin-like polysaccharide (K5-NSOS) inhibited TGF-beta-induced IL-11 production in MDA-MB-231(SA) cells.	Heparin	91-98	interleukin 11	Homo sapiens	156-161
22522458-5	2012	We subsequently showed how heparin and a high-molecular-weight Escherichia coli K5-derived heparin-like polysaccharide (K5-NSOS) inhibited TGF-beta-induced IL-11 production in MDA-MB-231(SA) cells.	Polysaccharides	104-118	interleukin 11	Homo sapiens	156-161
22522458-5	2012	We subsequently showed how heparin and a high-molecular-weight Escherichia coli K5-derived heparin-like polysaccharide (K5-NSOS) inhibited TGF-beta-induced IL-11 production in MDA-MB-231(SA) cells.	-nsos	122-127	interleukin 11	Homo sapiens	156-161
22151118-4	2012	Our objective was to study whether melatonin interferes in the desmoplastic reaction by regulating some factors secreted by malignant cells, tumor necrosis factor (TNF)-alpha, interleukin (IL)-11, and interleukin (IL)-6.	Melatonin	35-44	interleukin 11	Homo sapiens	176-195
22568077-0	2012	[Effects of anandamide on IL-11 production through the TRPV1 of human periodontal ligament cells].	anandamide	12-22	interleukin 11	Homo sapiens	26-31
22568077-8	2012	IL-11 production from hPDL cells was measured using an ELISA, with or without AEA in the presence or absence of capsazepine, a selective TRPV1 antagonist AEA secreted into GCF was detected, but there was no correlation between the probing pocket depth (PPD) and AEA level.	anandamide	154-157	interleukin 11	Homo sapiens	0-5
22568077-8	2012	IL-11 production from hPDL cells was measured using an ELISA, with or without AEA in the presence or absence of capsazepine, a selective TRPV1 antagonist AEA secreted into GCF was detected, but there was no correlation between the probing pocket depth (PPD) and AEA level.	anandamide	154-157	interleukin 11	Homo sapiens	0-5
22568077-10	2012	IL-11 production from hPDL cells was significantly enhanced by AEA stimulation and this IL-11 production was suppressed by capsazepine.	anandamide	63-66	interleukin 11	Homo sapiens	0-5
22568077-10	2012	IL-11 production from hPDL cells was significantly enhanced by AEA stimulation and this IL-11 production was suppressed by capsazepine.	capsazepine	123-134	interleukin 11	Homo sapiens	0-5
22568077-10	2012	IL-11 production from hPDL cells was significantly enhanced by AEA stimulation and this IL-11 production was suppressed by capsazepine.	capsazepine	123-134	interleukin 11	Homo sapiens	88-93
22138297-0	2012	MAPK- and PKC/CREB-dependent induction of interleukin-11 by the environmental contaminant formaldehyde in human bronchial epithelial cells.	Formaldehyde	90-102	interleukin 11	Homo sapiens	42-56
22138297-7	2012	Implication of protein kinase C (PKC) in FA-induced IL-11 expression was moreover demonstrated by using RO-31-8220, a PKC inhibitor.	Ro 31-8220	104-114	interleukin 11	Homo sapiens	52-57
22168497-6	2012	The cytoprotective effect of diazoxide preconditioning was blocked by Erk1/2 inhibitor PD98059 (20-100 microM), which abrogated STAT-3 phosphorylation, thus confirming a possible involvement of Erk1/2/STAT3 signaling downstream of IL-11 in cell survival.	Diazoxide	29-38	interleukin 11	Homo sapiens	231-236
23226926-7	2012	Moreover, GAgP group showed lower ratios of IL-11/IL-17 when compared to GCP group.	gagp	10-14	interleukin 11	Homo sapiens	44-49
22952917-5	2012	When stimulated with whole sperm cells, the PBMCs from patients with ASA produce less IL-3, IL-11, IL-13, ICAM-1, GCSF and more IL-2, IL-4 and IL-12p70 as compared to healthy women.	Aspirin	69-72	interleukin 11	Homo sapiens	92-97
22168497-6	2012	The cytoprotective effect of diazoxide preconditioning was blocked by Erk1/2 inhibitor PD98059 (20-100 microM), which abrogated STAT-3 phosphorylation, thus confirming a possible involvement of Erk1/2/STAT3 signaling downstream of IL-11 in cell survival.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	87-94	interleukin 11	Homo sapiens	231-236
21593768-7	2011	GW9508 further suppressed expression of IL-11, IL-24, and IL-33 induced in HaCaT cells by TNF-alpha and IFN-gamma.	GW9508	0-6	interleukin 11	Homo sapiens	40-45
21688034-7	2011	Erlotinib suppressed the production of osteolytic factors, such as parathyroid hormone-related protein (PTHrP), IL-8, IL-11 and vascular endothelial growth factor (VEGF) in NCI-H292 cells.	Erlotinib Hydrochloride	0-9	interleukin 11	Homo sapiens	118-123
21840908-7	2011	Protein disulfide isomerase family A, member 3 (PDIA3; endoplasmic reticulum p57) and glucose-regulated protein 78 (GRP78) were further validated to be regulated by IL11 in HTR8/SVneo and primary EVT.	EVT	196-199	interleukin 11	Homo sapiens	165-169
21840908-10	2011	Moreover, IL11 stimulated the secretion of GRP78 in EVT.	EVT	52-55	interleukin 11	Homo sapiens	10-14
21867643-4	2011	At day 7 of the second culture phase, the CD34(+) cells cultured with cytokine combination SCF + TPO + FL + IL-11 were amplified by (204666.7 +- 11718.9) times, which were significantly higher than that of cells cultured with SCF + TPO + FL + IL-3, but were not significantly different from that of cells cultured with SCF + TPO + FL + IL-11 + BMP4 + VEGF.	fl	103-105	interleukin 11	Homo sapiens	336-341
21619578-18	2011	These two case reports also demonstrate that patients with hepatic carcinoma who experience this rare form of CLS after treatment with IL-11 seem to respond to a therapeutic regimen that involves hydroxyethyl starch, albumin, and diuretic therapy.	Hydroxyethyl starch	196-215	interleukin 11	Homo sapiens	135-140
20926603-11	2011	Caspases were activated upon Fas-stimulation and the Fas-mediated effects on LIF, IL-11 and -8 were reversed by caspase-inhibition.	ammonium ferrous sulfate	29-32	interleukin 11	Homo sapiens	82-94
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Cysteine	110-113	interleukin 11	Homo sapiens	57-71
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Cysteine	110-113	interleukin 11	Homo sapiens	73-78
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Glycine	114-117	interleukin 11	Homo sapiens	57-71
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Glycine	114-117	interleukin 11	Homo sapiens	73-78
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Arginine	118-121	interleukin 11	Homo sapiens	57-71
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Arginine	118-121	interleukin 11	Homo sapiens	73-78
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Arginine	122-125	interleukin 11	Homo sapiens	57-71
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Arginine	122-125	interleukin 11	Homo sapiens	73-78
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Alanine	126-129	interleukin 11	Homo sapiens	57-71
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Alanine	126-129	interleukin 11	Homo sapiens	73-78
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Glycine	130-133	interleukin 11	Homo sapiens	57-71
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Glycine	130-133	interleukin 11	Homo sapiens	73-78
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Glycine	130-133	interleukin 11	Homo sapiens	57-71
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Glycine	130-133	interleukin 11	Homo sapiens	73-78
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Serine	138-141	interleukin 11	Homo sapiens	57-71
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Serine	138-141	interleukin 11	Homo sapiens	73-78
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Cysteine	142-145	interleukin 11	Homo sapiens	57-71
21548211-1	2011	OBJECTIVE: To investigate the binding characteristics of interleukin 11 (IL-11) analogue-cyclic nonapeptide c(Cys-Gly-Arg-Arg-Ala-Gly-Gly-Ser-Cys) NH2 C30H54N16O10S2, c(CGRRAGGSC), and human prostate cancer PC-3 cells.	Cysteine	142-145	interleukin 11	Homo sapiens	73-78
21238428-1	2011	Recombinant human interleukin-11 (rhIL-11) has been shown to increase platelet counts in animals and humans and is the only drug approved for its use in chemotherapy-induced thrombocytopenia (CIT).	cit	192-195	interleukin 11	Homo sapiens	18-32
20926603-11	2011	Caspases were activated upon Fas-stimulation and the Fas-mediated effects on LIF, IL-11 and -8 were reversed by caspase-inhibition.	ammonium ferrous sulfate	53-56	interleukin 11	Homo sapiens	82-94
20074812-0	2010	Interleukin 11 and activin A synergise to regulate progesterone-induced but not cAMP-induced decidualization.	Progesterone	51-63	interleukin 11	Homo sapiens	0-14
20360315-7	2010	A set of 72 a priori-selected candidate genes did not show pharmacogenetic associations above a chance level, but an association with response to escitalopram was detected in the interleukin-6 gene, which is a close homologue of IL11.	Citalopram	146-158	interleukin 11	Homo sapiens	229-233
20843944-12	2010	CONCLUSIONS: Medroxyprogesterone acetate controls expression of multiple genes in myometrium, including many that have not previously been characterized as progestogen regulated in this tissue, including IL-11 and IL-24.	Medroxyprogesterone Acetate	13-40	interleukin 11	Homo sapiens	204-209
20498256-3	2010	METHODS AND RESULTS: We report that pharmacological preconditioning of MY with diazoxide showed robust expression of IL-11 and activation of extracellular signal-regulated kinase 1/2 (Erk1/2) and signal transducers and activators of transcription-3 (Stat3) with concomitantly increased miR-21.	Diazoxide	79-88	interleukin 11	Homo sapiens	117-122
20478621-5	2010	The results demonstrated that the expression of IGFBP1, Prolactin (PRL), HOXA10, IL11, and IL15 are co-regulated during steroid hormone-mediated decidualization of human endometrial stromal cells in vitro.	Steroids	120-135	interleukin 11	Homo sapiens	81-85
20360315-6	2010	Response to escitalopram was best predicted by a marker in the interleukin-11 (IL11) gene.	Citalopram	12-24	interleukin 11	Homo sapiens	63-77
20360315-6	2010	Response to escitalopram was best predicted by a marker in the interleukin-11 (IL11) gene.	Citalopram	12-24	interleukin 11	Homo sapiens	79-83
20074812-9	2010	Inclusion of the TGFbeta 1 receptor inhibitor, SB431542, in the activin A treatment, reduced pSMAD2 and IL11 secretion.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	47-55	interleukin 11	Homo sapiens	104-108
19251839-8	2009	MEK inhibitors PD-98059, U0126, and Raf1 kinase inhibitor I, significantly inhibited IL-11 production, whereas overexpression of a Raf1 dominant-negative mutant inhibited its expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	15-23	interleukin 11	Homo sapiens	85-90
19801577-3	2010	Here, we have shown that PROK1-PROKR1 induces the expression of IL-11 in PROKR1 Ishikawa cells and first trimester decidua via the calcium-calcineurin signalling pathway in a guanine nucleotide-binding protein (G(q/11)), extracellular signal-regulated kinases, Ca(2+) and calcineurin-nuclear factor of activated T cells dependent manner.	Calcium	131-138	interleukin 11	Homo sapiens	64-69
19801577-3	2010	Here, we have shown that PROK1-PROKR1 induces the expression of IL-11 in PROKR1 Ishikawa cells and first trimester decidua via the calcium-calcineurin signalling pathway in a guanine nucleotide-binding protein (G(q/11)), extracellular signal-regulated kinases, Ca(2+) and calcineurin-nuclear factor of activated T cells dependent manner.	Guanine Nucleotides	175-193	interleukin 11	Homo sapiens	64-69
20008143-3	2010	This study investigated the expression of IL-11 and role of prostaglandin F(2alpha)-F-prostanoid receptor (FP receptor) signaling in the modulation of IL-11 expression in endometrial adenocarcinoma cells.	Prostaglandins F	60-75	interleukin 11	Homo sapiens	151-156
20008143-8	2010	Prostaglandin F(2alpha)-FP receptor signaling significantly elevated the expression of IL-11 mRNA and protein in a Gq-protein kinase C-calcium-calcineurin-nuclear factor of activated T cells-dependent manner in FPS cells.	Prostaglandins F	0-15	interleukin 11	Homo sapiens	87-92
19251839-8	2009	MEK inhibitors PD-98059, U0126, and Raf1 kinase inhibitor I, significantly inhibited IL-11 production, whereas overexpression of a Raf1 dominant-negative mutant inhibited its expression.	U 0126	25-30	interleukin 11	Homo sapiens	85-90
18987331-2	2009	In humans, during early pregnancy interleukin 11 (IL11) is maximally expressed in the decidua, with its receptor, IL11 receptor alpha (IL11RA), also identified on invasive EVTs in vivo.	evts	172-176	interleukin 11	Homo sapiens	50-54
18987331-2	2009	In humans, during early pregnancy interleukin 11 (IL11) is maximally expressed in the decidua, with its receptor, IL11 receptor alpha (IL11RA), also identified on invasive EVTs in vivo.	evts	172-176	interleukin 11	Homo sapiens	114-118
18987331-3	2009	Although a role for IL11 in EVT migration has been established, whether it also plays a role in regulating EVT invasion is unknown.	EVT	28-31	interleukin 11	Homo sapiens	20-24
18987331-5	2009	Interleukin 11 (100 ng/ml) significantly inhibited invasion of EVT cells by 40% to 60% (P < 0.001).	EVT	63-66	interleukin 11	Homo sapiens	0-14
18987331-9	2009	These data demonstrate that IL11 inhibits human EVT invasion via STAT3, indicating a likely role for IL11 in the decidual restraint of EVT invasion during normal pregnancy.	EVT	48-51	interleukin 11	Homo sapiens	28-32
18987331-9	2009	These data demonstrate that IL11 inhibits human EVT invasion via STAT3, indicating a likely role for IL11 in the decidual restraint of EVT invasion during normal pregnancy.	EVT	135-138	interleukin 11	Homo sapiens	28-32
18987331-9	2009	These data demonstrate that IL11 inhibits human EVT invasion via STAT3, indicating a likely role for IL11 in the decidual restraint of EVT invasion during normal pregnancy.	EVT	135-138	interleukin 11	Homo sapiens	101-105
18093851-6	2008	SB-203580 caused dose-dependent decreases in cytokine protein expression and decreased IL-6 and IL-11 mRNA expression.	SB 203580	0-9	interleukin 11	Homo sapiens	96-101
18718087-2	2008	Fusion expression vector pET32a/IL-11 was transferred into E.coli BL21 (DE3) pLysS and its expression was induced by IPTG, the lysis supernatant of the engineering strain was purified by Ni-NTA resin and then the target rhIL-11 was digested by auto-cleavaged DsbA-EKL-(His)(8).	Isopropyl Thiogalactoside	117-121	interleukin 11	Homo sapiens	32-37
18718087-2	2008	Fusion expression vector pET32a/IL-11 was transferred into E.coli BL21 (DE3) pLysS and its expression was induced by IPTG, the lysis supernatant of the engineering strain was purified by Ni-NTA resin and then the target rhIL-11 was digested by auto-cleavaged DsbA-EKL-(His)(8).	ni-nta	187-193	interleukin 11	Homo sapiens	32-37
17702845-8	2007	In EVT cells in vitro, IL-11: 1) stimulated phosphorylation of signal transducer and activator of transcription-3; 2) was without effect on EVT cell proliferation; and 3) stimulated significant migration of EVT-hybridoma cells (no endogenous IL-11), whereas in primary EVT, blocking endogenous IL-11 inhibited EVT migration by 30-40%.	EVT	3-6	interleukin 11	Homo sapiens	23-28
17956465-7	2007	RESULTS: Interleukin-11 enhanced alkaline phosphatase activity and Runx2, osteocalcin and bone sialoprotein gene expression in the presence of ascorbic acid.	Ascorbic Acid	143-156	interleukin 11	Homo sapiens	9-23
18199361-0	2007	Re: Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis.	Ifosfamide	30-40	interleukin 11	Homo sapiens	4-18
18199362-0	2007	Re: Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis.	Ifosfamide	30-40	interleukin 11	Homo sapiens	4-18
17956465-10	2007	Furthermore, janus kinase/signal transducers and activator of transcription and MAPK signaling inhibitors reduced interleukin-11/ascorbic acid-induced alkaline phosphatase activity in periodontal ligament cells.	Ascorbic Acid	129-142	interleukin 11	Homo sapiens	114-128
17702845-9	2007	These data demonstrate that IL-11 stimulates human EVT migration, but not proliferation, likely via signal transducer and activator of transcription-3, indicating an important role for IL-11 in placentation.	EVT	51-54	interleukin 11	Homo sapiens	28-33
17702845-9	2007	These data demonstrate that IL-11 stimulates human EVT migration, but not proliferation, likely via signal transducer and activator of transcription-3, indicating an important role for IL-11 in placentation.	EVT	51-54	interleukin 11	Homo sapiens	185-190
17295091-0	2007	Heme oxygenase-1 and interleukin-11 are overexpressed in stress-induced premature senescence of human WI-38 fibroblasts induced by tert-butylhydroperoxide and ethanol.	tert-Butylhydroperoxide	131-154	interleukin 11	Homo sapiens	21-35
17980069-0	2007	Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis.	Ifosfamide	26-36	interleukin 11	Homo sapiens	0-14
17980069-1	2007	OBJECTIVE: To investigate the possible protective effect of recombinant human interleukin-11 (rhIL-11) against ifosfamide (IFS)-induced hemorrhagic cystitis (HC).	Ifosfamide	111-121	interleukin 11	Homo sapiens	78-92
17980069-1	2007	OBJECTIVE: To investigate the possible protective effect of recombinant human interleukin-11 (rhIL-11) against ifosfamide (IFS)-induced hemorrhagic cystitis (HC).	Ifosfamide	123-126	interleukin 11	Homo sapiens	78-92
17295091-0	2007	Heme oxygenase-1 and interleukin-11 are overexpressed in stress-induced premature senescence of human WI-38 fibroblasts induced by tert-butylhydroperoxide and ethanol.	Ethanol	159-166	interleukin 11	Homo sapiens	21-35
17295091-2	2007	In the present work we found an increased mRNA and protein level of interleukin-11 and heme oxygenase-1 in premature senescence of WI-38 human diploid foetal lung fibroblasts induced by both tert-butylhydroperoxide and ethanol.	tert-Butylhydroperoxide	191-214	interleukin 11	Homo sapiens	68-82
17295091-2	2007	In the present work we found an increased mRNA and protein level of interleukin-11 and heme oxygenase-1 in premature senescence of WI-38 human diploid foetal lung fibroblasts induced by both tert-butylhydroperoxide and ethanol.	Ethanol	219-226	interleukin 11	Homo sapiens	68-82
17295091-3	2007	We tested whether interleukin-11 and heme oxygenase-1 could protect against tert-butylhydroperoxide- or ethanol-induced premature senescence when stable overexpression was established using a retroviral vector-based transduction.	tert-Butylhydroperoxide	76-99	interleukin 11	Homo sapiens	18-32
17295091-3	2007	We tested whether interleukin-11 and heme oxygenase-1 could protect against tert-butylhydroperoxide- or ethanol-induced premature senescence when stable overexpression was established using a retroviral vector-based transduction.	Ethanol	104-111	interleukin 11	Homo sapiens	18-32
16720575-9	2006	When taken together, these findings suggest that heparin enhances IL-11-induced STAT3 activation and thus osteoclast formation, by a mechanism that is independent of STAT3 Ser-727 phosphorylation but that involves up-regulation of the MAPK pathway.	Heparin	49-56	interleukin 11	Homo sapiens	66-71
17490774-0	2007	Enhanced pharmacological activity of recombinant human interleukin-11 (rhIL11) by chemical modification with polyethylene glycol.	Polyethylene Glycols	109-128	interleukin 11	Homo sapiens	55-69
17629706-8	2007	Finally we showed that IL-11 treatment conferred the resistance to cell death induced by hydrogen peroxide, which was abrogated by adenoviral transfer of dominant negative STAT3, but not by the inhibition of ERK1/2 with U0126.	Hydrogen Peroxide	89-106	interleukin 11	Homo sapiens	23-28
16973236-0	2006	Incorporation into a biodegradable hyaluronic acid matrix enhances in vivo efficacy of recombinant human interleukin 11 (rhIL11).	Hyaluronic Acid	35-50	interleukin 11	Homo sapiens	105-119
16720575-0	2006	Heparin synergistically enhances interleukin-11 signaling through up-regulation of the MAPK pathway.	Heparin	0-7	interleukin 11	Homo sapiens	33-47
16720575-2	2006	Furthermore, we found that, although heparin alone has no effect, it is able to synergistically enhance Interleukin-11 (IL-11)-induced signal transducer and activator of transcription 3 (STAT3) activation and thus increase osteoclast formation in vitro.	Heparin	37-44	interleukin 11	Homo sapiens	104-118
16720575-9	2006	When taken together, these findings suggest that heparin enhances IL-11-induced STAT3 activation and thus osteoclast formation, by a mechanism that is independent of STAT3 Ser-727 phosphorylation but that involves up-regulation of the MAPK pathway.	Serine	172-175	interleukin 11	Homo sapiens	66-71
16720575-2	2006	Furthermore, we found that, although heparin alone has no effect, it is able to synergistically enhance Interleukin-11 (IL-11)-induced signal transducer and activator of transcription 3 (STAT3) activation and thus increase osteoclast formation in vitro.	Heparin	37-44	interleukin 11	Homo sapiens	120-125
16720575-3	2006	In the present study, we examine the effect of various serine kinase inhibitors on the ability of heparin to act synergistically with IL-11.	Heparin	98-105	interleukin 11	Homo sapiens	134-139
16457848-10	2006	Furthermore, a treatment with low 1- to 2-microm concentration NS-398 or Celecoxib significantly reduced the production of IL-11 in COX-2-transfected MDA-231 cells, thus confirming the involvement of COX-2 in IL-11 induction.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	63-69	interleukin 11	Homo sapiens	123-128
16720575-5	2006	In contrast, PD098059, a MAPK kinase inhibitor, completely abolished the synergy between heparin and IL-11.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	13-21	interleukin 11	Homo sapiens	101-106
16457848-10	2006	Furthermore, a treatment with low 1- to 2-microm concentration NS-398 or Celecoxib significantly reduced the production of IL-11 in COX-2-transfected MDA-231 cells, thus confirming the involvement of COX-2 in IL-11 induction.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	63-69	interleukin 11	Homo sapiens	209-214
16457848-10	2006	Furthermore, a treatment with low 1- to 2-microm concentration NS-398 or Celecoxib significantly reduced the production of IL-11 in COX-2-transfected MDA-231 cells, thus confirming the involvement of COX-2 in IL-11 induction.	Celecoxib	73-82	interleukin 11	Homo sapiens	123-128
16457848-10	2006	Furthermore, a treatment with low 1- to 2-microm concentration NS-398 or Celecoxib significantly reduced the production of IL-11 in COX-2-transfected MDA-231 cells, thus confirming the involvement of COX-2 in IL-11 induction.	Celecoxib	73-82	interleukin 11	Homo sapiens	209-214
16002475-6	2005	Induction of IL-1alpha, IL-6, IL-11, and FGF-9 mRNA by MEP and benzo(a)pyrene was concentration and time dependent.	Benzo(a)pyrene	63-77	interleukin 11	Homo sapiens	30-35
16711008-0	2006	Effects of 17beta-estradiol on the expression of IL-6, IL-11 and NF-kappaB in human MG-63 osteoblast-like cell line.	Estradiol	11-27	interleukin 11	Homo sapiens	55-60
16711008-1	2006	In order to characterize the effects of 17beta-estradiol (17beta-E2) on the expression of IL-6, IL-11 and NF-kappaB in the human MG-63 osteoblast-like cell line, the expression of IL-6 was detected by RT-PCR, Northern blot and Western blot.	Estradiol	40-56	interleukin 11	Homo sapiens	96-101
16711008-1	2006	In order to characterize the effects of 17beta-estradiol (17beta-E2) on the expression of IL-6, IL-11 and NF-kappaB in the human MG-63 osteoblast-like cell line, the expression of IL-6 was detected by RT-PCR, Northern blot and Western blot.	17beta-e2	58-67	interleukin 11	Homo sapiens	96-101
16711008-3	2006	The results showed that 17beta-E2 down-regulated the expression of IL-6 mRNA and protein, IL-11 mRNA and NF-kappaB protein in MG-63 cells.	17beta-e2	24-33	interleukin 11	Homo sapiens	90-95
16338497-6	2005	These data indicate that heparin as effective cofactor for TPO and IL-11 promotes expansion of MK progenitor cells from CB CD34(+) cells.	Heparin	25-32	interleukin 11	Homo sapiens	67-72
16002475-8	2005	Treatment with MEP or benzo(a)pyrene increased IL-6 and IL-11 releases to CL5 cell medium.	Benzo(a)pyrene	22-36	interleukin 11	Homo sapiens	56-61
16003467-5	2005	In vitro expression of IL-11 in cultured macrophages is enhanced by stimulation with lipopolysaccharide and is markedly inhibited by cortisol.	Hydrocortisone	133-141	interleukin 11	Homo sapiens	23-28
16086584-2	2005	Madindoline A (MadA), isolated from Streptomyces nitrosporeus K93-0711, specifically inhibits the growth of IL-6- and IL-11-dependent cell lines, most likely by interfering with the homodimerization of gp130.	madindoline A	0-13	interleukin 11	Homo sapiens	118-123
15790759-9	2005	The delayed expression of endogenous IL-11 limited the expression of ICAM-1, and pretreatment of HCCSMC with antisense oligonucleotides to IL-11 enhanced it.	hccsmc	97-103	interleukin 11	Homo sapiens	139-144
15790759-9	2005	The delayed expression of endogenous IL-11 limited the expression of ICAM-1, and pretreatment of HCCSMC with antisense oligonucleotides to IL-11 enhanced it.	Oligonucleotides	119-135	interleukin 11	Homo sapiens	37-42
15790759-9	2005	The delayed expression of endogenous IL-11 limited the expression of ICAM-1, and pretreatment of HCCSMC with antisense oligonucleotides to IL-11 enhanced it.	Oligonucleotides	119-135	interleukin 11	Homo sapiens	139-144
15784719-7	2005	Cotreatment of HESC with RLX, PGE(2), or cAMP and estrogen plus P down-regulated IL-11 mRNA and IL-11 secretion at 24 h, before secretion of prolactin (decidualization marker).	Prostaglandins E	30-33	interleukin 11	Homo sapiens	81-86
15784719-2	2005	We investigated the effects of relaxin (RLX) and prostaglandin E(2) (PGE(2)) on IL-11 secretion by human endometrial stromal cells (HESC) and during cAMP or medroxyprogesterone acetate (P)-induced decidualization.	Relaxin	40-43	interleukin 11	Homo sapiens	80-85
15784719-5	2005	Addition of the cAMP/protein kinase A inhibitor Rp-adenosine-3,5-cyclic-monophosphorothioate to either RLX- or PGE(2)-treated cells decreased IL-11 secretion.	rp-adenosine-3,5-cyclic-monophosphorothioate	48-92	interleukin 11	Homo sapiens	142-147
15784719-2	2005	We investigated the effects of relaxin (RLX) and prostaglandin E(2) (PGE(2)) on IL-11 secretion by human endometrial stromal cells (HESC) and during cAMP or medroxyprogesterone acetate (P)-induced decidualization.	Dinoprostone	49-67	interleukin 11	Homo sapiens	80-85
15784719-5	2005	Addition of the cAMP/protein kinase A inhibitor Rp-adenosine-3,5-cyclic-monophosphorothioate to either RLX- or PGE(2)-treated cells decreased IL-11 secretion.	Relaxin	103-106	interleukin 11	Homo sapiens	142-147
15784719-2	2005	We investigated the effects of relaxin (RLX) and prostaglandin E(2) (PGE(2)) on IL-11 secretion by human endometrial stromal cells (HESC) and during cAMP or medroxyprogesterone acetate (P)-induced decidualization.	Prostaglandins E	69-72	interleukin 11	Homo sapiens	80-85
15784719-5	2005	Addition of the cAMP/protein kinase A inhibitor Rp-adenosine-3,5-cyclic-monophosphorothioate to either RLX- or PGE(2)-treated cells decreased IL-11 secretion.	Dinoprostone	111-117	interleukin 11	Homo sapiens	142-147
15784719-3	2005	cAMP-decidualized HESC secreted high levels of IL-11.	Cyclic AMP	0-4	interleukin 11	Homo sapiens	47-52
15784719-6	2005	Indomethacin treatment decreased IL-11 secretion, which was largely restored by cotreatment with PGE(2) or RLX.	Indomethacin	0-12	interleukin 11	Homo sapiens	33-38
15784719-4	2005	RLX, cAMP, or PGE(2) increased IL-11 mRNA and IL-11 secretion, with maximal response to RLX and cAMP.	Relaxin	0-3	interleukin 11	Homo sapiens	31-36
15784719-6	2005	Indomethacin treatment decreased IL-11 secretion, which was largely restored by cotreatment with PGE(2) or RLX.	Prostaglandins E	97-100	interleukin 11	Homo sapiens	33-38
15784719-4	2005	RLX, cAMP, or PGE(2) increased IL-11 mRNA and IL-11 secretion, with maximal response to RLX and cAMP.	Relaxin	0-3	interleukin 11	Homo sapiens	46-51
15784719-7	2005	Cotreatment of HESC with RLX, PGE(2), or cAMP and estrogen plus P down-regulated IL-11 mRNA and IL-11 secretion at 24 h, before secretion of prolactin (decidualization marker).	Relaxin	25-28	interleukin 11	Homo sapiens	81-86
15784719-4	2005	RLX, cAMP, or PGE(2) increased IL-11 mRNA and IL-11 secretion, with maximal response to RLX and cAMP.	Cyclic AMP	5-9	interleukin 11	Homo sapiens	31-36
15784719-7	2005	Cotreatment of HESC with RLX, PGE(2), or cAMP and estrogen plus P down-regulated IL-11 mRNA and IL-11 secretion at 24 h, before secretion of prolactin (decidualization marker).	Relaxin	25-28	interleukin 11	Homo sapiens	96-101
15784719-4	2005	RLX, cAMP, or PGE(2) increased IL-11 mRNA and IL-11 secretion, with maximal response to RLX and cAMP.	Cyclic AMP	5-9	interleukin 11	Homo sapiens	46-51
15784719-7	2005	Cotreatment of HESC with RLX, PGE(2), or cAMP and estrogen plus P down-regulated IL-11 mRNA and IL-11 secretion at 24 h, before secretion of prolactin (decidualization marker).	Prostaglandins E	30-33	interleukin 11	Homo sapiens	96-101
15784719-7	2005	Cotreatment of HESC with RLX, PGE(2), or cAMP and estrogen plus P down-regulated IL-11 mRNA and IL-11 secretion at 24 h, before secretion of prolactin (decidualization marker).	Cyclic AMP	41-45	interleukin 11	Homo sapiens	81-86
15784719-4	2005	RLX, cAMP, or PGE(2) increased IL-11 mRNA and IL-11 secretion, with maximal response to RLX and cAMP.	Prostaglandins E	14-17	interleukin 11	Homo sapiens	31-36
15784719-7	2005	Cotreatment of HESC with RLX, PGE(2), or cAMP and estrogen plus P down-regulated IL-11 mRNA and IL-11 secretion at 24 h, before secretion of prolactin (decidualization marker).	Cyclic AMP	41-45	interleukin 11	Homo sapiens	96-101
15784719-4	2005	RLX, cAMP, or PGE(2) increased IL-11 mRNA and IL-11 secretion, with maximal response to RLX and cAMP.	Prostaglandins E	14-17	interleukin 11	Homo sapiens	46-51
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Prostaglandins E	100-103	interleukin 11	Homo sapiens	17-22
15784719-4	2005	RLX, cAMP, or PGE(2) increased IL-11 mRNA and IL-11 secretion, with maximal response to RLX and cAMP.	Cyclic AMP	96-100	interleukin 11	Homo sapiens	31-36
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Prostaglandins E	100-103	interleukin 11	Homo sapiens	24-29
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Prostaglandins E	100-103	interleukin 11	Homo sapiens	24-29
15784719-4	2005	RLX, cAMP, or PGE(2) increased IL-11 mRNA and IL-11 secretion, with maximal response to RLX and cAMP.	Cyclic AMP	96-100	interleukin 11	Homo sapiens	46-51
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Prostaglandins E	100-103	interleukin 11	Homo sapiens	24-29
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Cyclic AMP	165-169	interleukin 11	Homo sapiens	17-22
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Cyclic AMP	165-169	interleukin 11	Homo sapiens	24-29
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Cyclic AMP	165-169	interleukin 11	Homo sapiens	24-29
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Cyclic AMP	165-169	interleukin 11	Homo sapiens	24-29
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Relaxin	93-96	interleukin 11	Homo sapiens	17-22
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Relaxin	93-96	interleukin 11	Homo sapiens	24-29
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Relaxin	93-96	interleukin 11	Homo sapiens	24-29
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Relaxin	93-96	interleukin 11	Homo sapiens	24-29
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Prostaglandins E	267-270	interleukin 11	Homo sapiens	17-22
15784719-5	2005	Addition of the cAMP/protein kinase A inhibitor Rp-adenosine-3,5-cyclic-monophosphorothioate to either RLX- or PGE(2)-treated cells decreased IL-11 secretion.	Cyclic AMP	16-20	interleukin 11	Homo sapiens	142-147
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Prostaglandins E	267-270	interleukin 11	Homo sapiens	24-29
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Prostaglandins E	267-270	interleukin 11	Homo sapiens	24-29
15613426-2	2005	In this study, we investigate the function of IL-11 signaling in cAMP-induced decidualization of human endometrial stromal cells.	Cyclic AMP	65-69	interleukin 11	Homo sapiens	46-51
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Prostaglandins E	267-270	interleukin 11	Homo sapiens	24-29
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Cyclic AMP	288-292	interleukin 11	Homo sapiens	17-22
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Cyclic AMP	288-292	interleukin 11	Homo sapiens	24-29
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Cyclic AMP	288-292	interleukin 11	Homo sapiens	24-29
15784719-8	2005	Addition of W147AIL-11 (IL-11 signaling inhibitor) reduced prolactin secretion stimulated by RLX or PGE(2) and estrogen plus P. This is the first demonstration that cAMP-decidualized HESC secrete IL-11 and that IL-11 mRNA and IL-11 secretion are regulated by RLX and PGE(2), partly via a cAMP/protein kinase A-dependent pathway.	Cyclic AMP	288-292	interleukin 11	Homo sapiens	24-29
15784719-9	2005	Blocking IL-11 signaling reduced RLX+P- or PGE(2)+P-induced decidualization, suggesting that RLX and PGE(2) act via IL-11.	rlx+p	33-38	interleukin 11	Homo sapiens	9-14
15784719-9	2005	Blocking IL-11 signaling reduced RLX+P- or PGE(2)+P-induced decidualization, suggesting that RLX and PGE(2) act via IL-11.	Dinoprostone	43-49	interleukin 11	Homo sapiens	9-14
15784719-9	2005	Blocking IL-11 signaling reduced RLX+P- or PGE(2)+P-induced decidualization, suggesting that RLX and PGE(2) act via IL-11.	Phosphorus	37-38	interleukin 11	Homo sapiens	9-14
15784719-9	2005	Blocking IL-11 signaling reduced RLX+P- or PGE(2)+P-induced decidualization, suggesting that RLX and PGE(2) act via IL-11.	Prostaglandins E	43-46	interleukin 11	Homo sapiens	9-14
15613426-3	2005	We show that treatment of endometrial stromal cells with 8-bromo-cAMP (8-Br-cAMP) results in an increase in the levels of secreted IL-11, whereas levels of cell surface IL-11 receptor alpha are similar with or without 8-Br-cAMP treatment.	8-Bromo Cyclic Adenosine Monophosphate	71-80	interleukin 11	Homo sapiens	131-136
15613426-3	2005	We show that treatment of endometrial stromal cells with 8-bromo-cAMP (8-Br-cAMP) results in an increase in the levels of secreted IL-11, whereas levels of cell surface IL-11 receptor alpha are similar with or without 8-Br-cAMP treatment.	8-Bromo Cyclic Adenosine Monophosphate	57-69	interleukin 11	Homo sapiens	131-136
15613426-6	2005	We demonstrate that 8-Br-cAMP-induced endometrial stromal cells derived from patients with primary infertility produce lower levels of prolactin, IGF-binding protein-1, and IL-11 than cells derived from fertile women.	8-br	20-24	interleukin 11	Homo sapiens	173-178
15613426-6	2005	We demonstrate that 8-Br-cAMP-induced endometrial stromal cells derived from patients with primary infertility produce lower levels of prolactin, IGF-binding protein-1, and IL-11 than cells derived from fertile women.	Cyclic AMP	25-29	interleukin 11	Homo sapiens	173-178
15381181-0	2004	Endogenous interleukin-11 (IL-11) levels in newly diagnosed children with acquired severe aplastic anemia (SAA).	saa	107-110	interleukin 11	Homo sapiens	11-25
15465850-13	2004	IL-11 is up-regulated by estrogen and down-regulated by progesterone.	Progesterone	56-68	interleukin 11	Homo sapiens	0-5
15606549-0	2005	Phase I/II dose escalation study of recombinant human interleukin-11 following ifosfamide, carboplatin and etoposide in children, adolescents and young adults with solid tumours or lymphoma: a clinical, haematological and biological study.	Ifosfamide	79-89	interleukin 11	Homo sapiens	54-68
15606549-0	2005	Phase I/II dose escalation study of recombinant human interleukin-11 following ifosfamide, carboplatin and etoposide in children, adolescents and young adults with solid tumours or lymphoma: a clinical, haematological and biological study.	Carboplatin	91-102	interleukin 11	Homo sapiens	54-68
15606549-0	2005	Phase I/II dose escalation study of recombinant human interleukin-11 following ifosfamide, carboplatin and etoposide in children, adolescents and young adults with solid tumours or lymphoma: a clinical, haematological and biological study.	Etoposide	107-116	interleukin 11	Homo sapiens	54-68
15854322-7	2004	Indomethacin, an inhibitor of prostaglandin synthesis, significantly reduced IL-11 production by HGFs stimulated with IL-1alpha and TNF-alpha individually or in combination.	Indomethacin	0-12	interleukin 11	Homo sapiens	77-82
15854322-7	2004	Indomethacin, an inhibitor of prostaglandin synthesis, significantly reduced IL-11 production by HGFs stimulated with IL-1alpha and TNF-alpha individually or in combination.	Prostaglandins	30-43	interleukin 11	Homo sapiens	77-82
15854322-8	2004	IL-1alpha alone or combined with TNF-alpha enhanced the ratio of IL-11/GAPDH mRNA expression in HGFs, and the augmentation was abolished by indomethacin after co-incubation for 24 hs.	Indomethacin	140-152	interleukin 11	Homo sapiens	65-70
15854322-9	2004	CONCLUSIONS: Production of IL-11 in HGFs stimulated with IL-1alpha and TNF-alpha was transcriptionally upregulated by the endogenous prostaglandin synthesis.	Prostaglandins	133-146	interleukin 11	Homo sapiens	27-32
15854322-10	2004	Inhibition of prostaglandin might suppress the osteoclastogenesis by IL-11 in inflammatory periodontal diseases.	Prostaglandins	14-27	interleukin 11	Homo sapiens	69-74
15381181-0	2004	Endogenous interleukin-11 (IL-11) levels in newly diagnosed children with acquired severe aplastic anemia (SAA).	saa	107-110	interleukin 11	Homo sapiens	27-32
15381181-3	2004	OBJECTIVE: To measure interleukin-11 levels in newly diagnosed SAA children and attempt to correlate levels with disease severity and response to therapy.	saa	63-66	interleukin 11	Homo sapiens	22-36
15381181-10	2004	Further studies are warranted to determine what, if any, role this plays in the development of this disorder and if the administration of recombinant human IL-11 might be beneficial in the treatment of acquired SAA.	saa	211-214	interleukin 11	Homo sapiens	156-161
15120938-0	2004	Interleukin 11 May improve thrombocytopenia associated with imatinib mesylate therapy in chronic Myelogenous leukemia.	Imatinib Mesylate	60-77	interleukin 11	Homo sapiens	0-14
15385498-1	2004	We have previously demonstrated that human gingival fibroblasts rescue butyric acid-induced T-cell apoptosis via proinflammatory cytokines such as interleukin 6 (IL-6) and IL-11, which are produced by fibroblasts stimulated with butyric acid.	Butyric Acid	71-83	interleukin 11	Homo sapiens	172-177
15207245-4	2004	The alteration in Galpha(i2) protein corresponds to and provides a molecular rationale for our previously described IL-11 induced increase in plasma membrane glucose transporter content and increased rate of glucose transport.	Glucose	158-165	interleukin 11	Homo sapiens	116-121
15207245-4	2004	The alteration in Galpha(i2) protein corresponds to and provides a molecular rationale for our previously described IL-11 induced increase in plasma membrane glucose transporter content and increased rate of glucose transport.	Glucose	208-215	interleukin 11	Homo sapiens	116-121
15385498-1	2004	We have previously demonstrated that human gingival fibroblasts rescue butyric acid-induced T-cell apoptosis via proinflammatory cytokines such as interleukin 6 (IL-6) and IL-11, which are produced by fibroblasts stimulated with butyric acid.	Butyric Acid	229-241	interleukin 11	Homo sapiens	172-177
15377473-9	2004	The presence of the RANK-Fc that blocks the RANK/RANKL interaction significantly inhibited HMCL-induced secretion of IL-6 and IL-11.	hmcl	91-95	interleukin 11	Homo sapiens	126-131
15120938-4	2004	We report on the use of interleukin-11 in three CML patients with grade > or =3, imatinib-induced thrombocytopenia.	Imatinib Mesylate	84-92	interleukin 11	Homo sapiens	24-38
15120938-5	2004	In all three patients, interleukin-11 led to improved platelets, uninterrupted administration of imatinib and improved cytogenetic response.	Imatinib Mesylate	97-105	interleukin 11	Homo sapiens	23-37
15120938-6	2004	This observation suggests that interleukin-11 may be beneficial for patients with imatinib-induced thrombocytoepnia.	Imatinib Mesylate	82-90	interleukin 11	Homo sapiens	31-45
12522661-3	2003	The aim of this study was to evaluate the effect of etidronate (10-4-10-9 M) and alendronate (10-7-10-12 M) on the production of IL-6 and IL-11 using human osteoblast cultures.	Etidronic Acid	52-62	interleukin 11	Homo sapiens	138-143
14999770-10	2004	The osteoclastogenic activity of IL-11 was mediated by enhancing osteoblast production of PGE(2) effects, which were abrogated by an inhibitor of cyclooxygenase.	Prostaglandins E	90-93	interleukin 11	Homo sapiens	33-38
14701802-9	2004	However, IL-11 stimulation resulted in a dose-dependent tyrosine phosphorylation of Akt, a decreased activation of caspase-9, and a reduced induction of apoptosis in cultured CEC.	Tyrosine	56-64	interleukin 11	Homo sapiens	9-14
12760902-11	2003	IL-1beta and TGF-beta1 induced an activation of ERK p42/44 and p38 MAP kinases, and the MAP kinase inhibitors (SB-202190, PD-98059, and U-0216) significantly reduced the IL-1beta- and TGF-beta1-induced IL-11 secretion.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	122-130	interleukin 11	Homo sapiens	202-207
12697042-7	2003	Similar to IL-6, both constitutive and IL-1beta-inducible IL-11 release were dose-dependently inhibited by cortisol (P<0.01); at variance with IL-6, exogenous IL-11 dose-dependently decreased GR numbers in MG-63 cells (P<0.05), while anti-IL-11 antibody significantly increased GR numbers in both cell lines (P<0.05).	Hydrocortisone	107-115	interleukin 11	Homo sapiens	58-63
12697042-7	2003	Similar to IL-6, both constitutive and IL-1beta-inducible IL-11 release were dose-dependently inhibited by cortisol (P<0.01); at variance with IL-6, exogenous IL-11 dose-dependently decreased GR numbers in MG-63 cells (P<0.05), while anti-IL-11 antibody significantly increased GR numbers in both cell lines (P<0.05).	Hydrocortisone	107-115	interleukin 11	Homo sapiens	162-167
12697042-7	2003	Similar to IL-6, both constitutive and IL-1beta-inducible IL-11 release were dose-dependently inhibited by cortisol (P<0.01); at variance with IL-6, exogenous IL-11 dose-dependently decreased GR numbers in MG-63 cells (P<0.05), while anti-IL-11 antibody significantly increased GR numbers in both cell lines (P<0.05).	Hydrocortisone	107-115	interleukin 11	Homo sapiens	162-167
12697042-10	2003	Our data indicate that even physiological concentrations of cortisol negatively modulate IL-11 secretion and demonstrate, for the first time, an inhibitory effect of the cytokine on GR.	Hydrocortisone	60-68	interleukin 11	Homo sapiens	89-94
14762907-0	2004	Optimizing storage stability of lyophilized recombinant human interleukin-11 with disaccharide/hydroxyethyl starch mixtures.	Disaccharides	82-94	interleukin 11	Homo sapiens	62-76
14734714-8	2004	Topical application of survivin antisense oligonucleotide down-regulates survivin expression in both cell types and largely abrogates the protective effect of IL-11.	Oligonucleotides	42-57	interleukin 11	Homo sapiens	159-164
14720445-7	2003	The percentages of CD(34)(+)CD(38)(-) primitive progenitors in the cultures of Tpo, IL-11 and Tpo + IL-11 modified HFCL were (1.8 +/- 0.24)%, (1.62 +/- 0.23)%, and (2.45 +/- 0.28)%, respectively, which were higher than that in the control [(0.8 +/- 0.23)%].	Cadmium	19-21	interleukin 11	Homo sapiens	100-105
12714376-10	2003	IL-11 inhibited Fas-induced apoptosis and increased Bcl-2 expression in both normal-Fb and IPF-Fb.	ammonium ferrous sulfate	16-19	interleukin 11	Homo sapiens	0-5
12730073-0	2003	Interleukin-11 and interleukin-6 protect cultured human endothelial cells from H2O2-induced cell death.	Hydrogen Peroxide	79-83	interleukin 11	Homo sapiens	0-14
12730073-2	2003	Previous studies have determined that both interleukin (IL)-6 and IL-11 are protective in oxygen toxicity.	Oxygen	90-96	interleukin 11	Homo sapiens	66-71
12730073-7	2003	We found that preincubation of HUVEC cultures with either IL-6 or IL-11 diminished H2O2 (1.0 mM)-induced cell death.	Hydrogen Peroxide	83-87	interleukin 11	Homo sapiens	66-71
12730073-9	2003	The protective effects of both IL-6 and IL-11 were not associated with any changes in antioxidants and were decreased by approximately 80% in the presence of U0126, a specific inhibitor of MEK-1-dependent pathways.	U 0126	158-163	interleukin 11	Homo sapiens	40-45
14520110-0	2003	IL-11 and IL-17 expression in nasal polyps: relationship to collagen deposition and suppression by intranasal fluticasone propionate.	Fluticasone	110-132	interleukin 11	Homo sapiens	0-5
12522661-3	2003	The aim of this study was to evaluate the effect of etidronate (10-4-10-9 M) and alendronate (10-7-10-12 M) on the production of IL-6 and IL-11 using human osteoblast cultures.	Alendronate	81-92	interleukin 11	Homo sapiens	138-143
12543079-0	2002	Effect of azacytidine in the release of leukemia inhibitory factor, oncostatin m, interleukin (IL)-6, and IL-11 by mononuclear cells of patients with refractory anemia.	Azacitidine	10-21	interleukin 11	Homo sapiens	106-111
12486609-7	2002	Dinucleotide repeat frequencies of the IL11.A1 allele and of IL11.A1 homozygous individuals were significantly increased among the patients with UC (P < 0.002 and (P < 0.003, respectively) but not with CD.	Dinucleoside Phosphates	0-12	interleukin 11	Homo sapiens	39-43
12486609-7	2002	Dinucleotide repeat frequencies of the IL11.A1 allele and of IL11.A1 homozygous individuals were significantly increased among the patients with UC (P < 0.002 and (P < 0.003, respectively) but not with CD.	Dinucleoside Phosphates	0-12	interleukin 11	Homo sapiens	61-65
12569176-8	2003	HB-EGF induced IL-11 secretion by cultured stromal cells, and IL-11 induced [(3)H]thymidine uptake by these cells.	Thymidine	82-91	interleukin 11	Homo sapiens	62-67
12543079-5	2002	AZA down-regulated OSM, IL-6, and IL-11 release by MNC of patients but not by MNC from healthy individuals.	Azacitidine	0-3	interleukin 11	Homo sapiens	34-39
12543079-9	2002	We conclude that: (a) AZA inhibits the release of OSM, IL-6, and IL-11 exclusively in RA-diseased MNC, (b) Patient"s MNC release subnormal amounts of LIF, OSM, and IL-11, and (c) RA-derived monocytes probably down-regulate OSM release by phytohemagglutinin-activated MNC.	Azacitidine	22-25	interleukin 11	Homo sapiens	65-70
12543079-9	2002	We conclude that: (a) AZA inhibits the release of OSM, IL-6, and IL-11 exclusively in RA-diseased MNC, (b) Patient"s MNC release subnormal amounts of LIF, OSM, and IL-11, and (c) RA-derived monocytes probably down-regulate OSM release by phytohemagglutinin-activated MNC.	Azacitidine	22-25	interleukin 11	Homo sapiens	164-169
12110441-5	2002	Mouse and human IL-11 also stimulated release of (3)H from [(3)H]-proline-labeled bones.	Proline	66-73	interleukin 11	Homo sapiens	16-21
12240950-0	2002	Characterization of asparagine deamidation and aspartate isomerization in recombinant human interleukin-11.	Asparagine	20-30	interleukin 11	Homo sapiens	92-106
12240950-0	2002	Characterization of asparagine deamidation and aspartate isomerization in recombinant human interleukin-11.	Aspartic Acid	47-56	interleukin 11	Homo sapiens	92-106
12087078-9	2002	Our observations demonstrate that human endometrial stromal cells produce biologically active IL-11, which promotes progesterone-induced decidualization.	Progesterone	116-128	interleukin 11	Homo sapiens	94-99
11161848-3	2001	The ability of IL-11 to stimulate [3H]thymidine incorporation in IL-11R-expressing ovarian carcinoma cell lines (OVCAR-3 and SKOV-3) and/or abrogate cell death mediated by apoptosis-inducing agents using an ELISA assay that quantitates DNA fragmentation was also studied.	Tritium	35-37	interleukin 11	Homo sapiens	15-20
11953371-8	2002	In contrast, IL-6 and IL-11 significantly suppressed butyric acid- or Fas-induced apoptosis in a dose-dependent fashion.	Butyric Acid	53-65	interleukin 11	Homo sapiens	22-27
11953371-8	2002	In contrast, IL-6 and IL-11 significantly suppressed butyric acid- or Fas-induced apoptosis in a dose-dependent fashion.	ammonium ferrous sulfate	70-73	interleukin 11	Homo sapiens	22-27
11953371-10	2002	These results suggest that the proinflammatory cytokines such as IL-6 and IL-11, produced in fibroblasts stimulated with butyric acid, are involved in the attenuation of T-cell apoptosis by gingival fibroblasts.	Butyric Acid	121-133	interleukin 11	Homo sapiens	74-79
11788590-5	2002	Interleukin 6 and interleukin 11, known to activate STAT3 synergistically, stimulated the SP-B promoter activity with retinoic acid, which is at least partially mediated through interactions between STAT3 and retinoid nuclear receptor enhanceosome proteins in pulmonary epithelial cells.	Tretinoin	118-131	interleukin 11	Homo sapiens	18-32
11784299-0	2002	Engineering and use of (32)P-labeled human recombinant interleukin-11 for receptor binding studies.	Phosphorus-32	23-28	interleukin 11	Homo sapiens	55-69
11977595-1	2002	A recombinant transfer vector, pBacIL-11, containing hIL-11 cDNA of 546 nucleotides lacking leader sequence was constructed and co-transfected into BmN cells with linearized BmBacPAK(modified BmNPV) DNA for construction of a recombinant baculovirus carrying the hIL-11 gene.	pbacil-11	31-40	interleukin 11	Homo sapiens	53-59
11977595-5	2002	Specific hIL-11 bands were detected from all the samples of cell extract, culture supernatant, haemolymph of larvae and pupae by SDS-PAGE analysis.	Sodium Dodecyl Sulfate	129-132	interleukin 11	Homo sapiens	9-15
11510989-6	2001	It is now apparent that the constitutive elevation in cAMP level induced by the Gsalpha mutations leads to alterations in the expression of several target genes whose promoters contain cAMP-responsive elements, such as c-fos, c-jun, Il-6 and Il-11.	Cyclic AMP	54-58	interleukin 11	Homo sapiens	242-247
11510989-6	2001	It is now apparent that the constitutive elevation in cAMP level induced by the Gsalpha mutations leads to alterations in the expression of several target genes whose promoters contain cAMP-responsive elements, such as c-fos, c-jun, Il-6 and Il-11.	Cyclic AMP	185-189	interleukin 11	Homo sapiens	242-247
11862431-0	2002	Recombinant human interleukin-11 improved carboplatin-induced thrombocytopenia without affecting antitumor activities in mice bearing Lewis lung carcinoma cells.	Carboplatin	42-53	interleukin 11	Homo sapiens	18-32
11544464-11	2001	IL-17 did enhance the production of pro-fibrotic cytokines (IL-6 and IL-11) by fibroblasts, and this was inhibited by dexamethasone.	Dexamethasone	118-131	interleukin 11	Homo sapiens	69-74
11560100-4	2001	IL-11 enhanced cell viability and prolactin secretion of 8-Br-cAMP-induced decidualized cells but not of non-stimulated stromal cells.	8-Bromo Cyclic Adenosine Monophosphate	57-66	interleukin 11	Homo sapiens	0-5
11560100-5	2001	IL-11 dose-dependently enhanced the viability of stromal cells co-stimulated with 8-Br-cAMP and IL-11 without any significant effect on prolactin secretion from the cells.	8-Bromo Cyclic Adenosine Monophosphate	82-91	interleukin 11	Homo sapiens	0-5
11560100-7	2001	These results indicate that IL-11 enhances the viability of 8-Br-cAMP-stimulated stromal cells and of decidualized stromal cells, and that the cell survival signals generated by IL-11 are independent of those generated by the extracellular matrix.	8-Bromo Cyclic Adenosine Monophosphate	60-69	interleukin 11	Homo sapiens	28-33
11438043-1	2001	Interleukin-11 (IL-11) is a pleiotropic cytokine that regulates the growth and development of hematopoietic stem cells and decreases the proinflammatory mediators of cytokine and nitric oxide production.	Nitric Oxide	179-191	interleukin 11	Homo sapiens	0-14
11172736-0	2001	Signal transduction system for interleukin-6 and interleukin-11 synthesis stimulated by epinephrine in human osteoblasts and human osteogenic sarcoma cells.	Epinephrine	88-99	interleukin 11	Homo sapiens	49-63
11172736-2	2001	An increase in IL-6 and IL-11 synthesis in response to epinephrine appeared to be a common feature in osteoblastic cells, but the magnitude of expression was different in these cell lines.	Epinephrine	55-66	interleukin 11	Homo sapiens	24-29
11172736-6	2001	The findings of the present study suggest that coinduction of IL-6 and IL-11 in response to epinephrine probably occurs via the PKA and p38 MAPK systems, leading to the transcriptional activation of AP-1 in human osteoblastic cells.	Epinephrine	92-103	interleukin 11	Homo sapiens	71-76
11438043-1	2001	Interleukin-11 (IL-11) is a pleiotropic cytokine that regulates the growth and development of hematopoietic stem cells and decreases the proinflammatory mediators of cytokine and nitric oxide production.	Nitric Oxide	179-191	interleukin 11	Homo sapiens	16-21
10934644-7	2000	Osteoclast formation also was stimulated (in the presence of Dex) by prostaglandin E2 (PGE2), interleukin-11 (IL-11), IL-1, tumor necrosis factor-alpha (TNF-alpha), and parathyroid hormone-related protein (PTHrP), factors which also stimulate osteoclast formation supported by osteoblasts.	Dexamethasone	61-64	interleukin 11	Homo sapiens	94-108
10948192-7	2000	We also show that a stable high affinity complex of IL-11, IL-11R, and gp130 can be resolved by nondenaturing polyacrylamide gel electrophoresis, and its composition verified by second dimension denaturing polyacrylamide gel electrophoresis.	polyacrylamide	110-124	interleukin 11	Homo sapiens	52-57
10948192-7	2000	We also show that a stable high affinity complex of IL-11, IL-11R, and gp130 can be resolved by nondenaturing polyacrylamide gel electrophoresis, and its composition verified by second dimension denaturing polyacrylamide gel electrophoresis.	polyacrylamide	206-220	interleukin 11	Homo sapiens	52-57
10945850-0	2000	Dose-dependent effects of recombinant human interleukin-11 on contractile properties in rabbit 2,4,6-trinitrobenzene sulfonic acid colitis.	Trinitrobenzenesulfonic Acid	95-130	interleukin 11	Homo sapiens	44-58
10934644-7	2000	Osteoclast formation also was stimulated (in the presence of Dex) by prostaglandin E2 (PGE2), interleukin-11 (IL-11), IL-1, tumor necrosis factor-alpha (TNF-alpha), and parathyroid hormone-related protein (PTHrP), factors which also stimulate osteoclast formation supported by osteoblasts.	Dexamethasone	61-64	interleukin 11	Homo sapiens	110-115
10908690-5	2000	RESULTS: IL-4 inhibited the production of IL-11 by FRS in a dose-dependent manner.	UNII-CL76HU6PN3	51-54	interleukin 11	Homo sapiens	42-47
10888110-0	2000	Thrombopoietic activity of recombinant human interleukin-11 in nonhuman primates with ACNU-induced thrombocytopenia.	Nimustine	86-90	interleukin 11	Homo sapiens	45-59
10888110-1	2000	The effect of recombinant human interleukin-11 (rHuIL-11) on myelosuppressive nimustine (ACNU)-induced thrombocytopenia was assessed in nonhuman primates.	Nimustine	78-87	interleukin 11	Homo sapiens	32-46
10725745-3	2000	Human IL-11 causes rapid (2-10 min) tyrosine phosphorylation of gp130.	Tyrosine	36-44	interleukin 11	Homo sapiens	6-11
10725745-4	2000	IL-11 at 0.1 and 10 ng/ml induces tyrosine phosphorylation of STAT3 and STAT1, respectively, although maximal responses require 50 ng/ml.	Tyrosine	34-42	interleukin 11	Homo sapiens	0-5
10467228-7	1999	Dexamethasone markedly suppressed basal production of interleukin (IL)-6 and IL-11 and that stimulated by parathyroid hormone (PTH), IL-1alpha, or tumour necrosis factor-alpha in a dose-dependent manner.	Dexamethasone	0-13	interleukin 11	Homo sapiens	77-82
10836206-9	2000	Addition of phosphatidylinositol (PI)-3 kinase inhibitors blocked IL-11 enhanced adhesion of CD34+ cells to fibronectin.	Phosphatidylinositols	12-32	interleukin 11	Homo sapiens	66-71
10859482-3	2000	In the present study, the effect of recombinant human IL-11 (hrIL-11) injected intracerebroventricularly on body temperature of afebrile and febrile rats was studied.	hril-11	61-68	interleukin 11	Homo sapiens	54-59
10537132-9	1999	Interleukin-11 blocked the induction by troglitazone of adipogenesis, but had no effect on the inhibition of osteoclast-like cell formation.	Troglitazone	40-52	interleukin 11	Homo sapiens	0-14
10623427-0	1999	Differential effects of IL-8, LIF (pro-inflammatory) and IL-11 (anti-inflammatory) on TNF-alpha-induced PGE(2)release and on signalling pathways in human OA synovial fibroblasts.	Prostaglandins E	104-107	interleukin 11	Homo sapiens	57-62
10620068-9	1999	The IL-11 mRNA up-regulation in SaOS-2 cells by the 6 h-FSS was not inhibited by the anti-human transforming growth factor-beta1 antibody, but it was significantly inhibited by indomethacin.	Indomethacin	177-189	interleukin 11	Homo sapiens	4-9
10620068-11	1999	These findings thus suggest that FSS induces osteoblasts to produce IL-11 (mediated by prostaglandins) and thus stimulates bone remodeling.	Prostaglandins	87-101	interleukin 11	Homo sapiens	68-73
10467228-9	1999	As both basal and PTH-stimulated production of IL-6 and IL-11 are decreased by dexamethasone, the increased bone resorption observed in glucocorticoid-induced osteopenia does not appear to be mediated by IL-6 or IL-11.	Dexamethasone	79-92	interleukin 11	Homo sapiens	56-61
10542977-0	1999	Role of the endogenous prostaglandin E2 in human lung fibroblast interleukin-11 production.	Dinoprostone	23-39	interleukin 11	Homo sapiens	65-79
10542977-6	1999	The addition of indomethacin, a cyclo-oxygenase inhibitor, resulted in significant suppression of IL-11 production and mRNA expression in lung fibroblasts.	Indomethacin	16-28	interleukin 11	Homo sapiens	98-103
10542977-7	1999	There was no detectable effect of PGE2 alone on IL-11 levels; however, the suppression of IL-11 production by indomethacin was almost completely reversed by addition of PGE2.	Indomethacin	110-122	interleukin 11	Homo sapiens	90-95
10542977-7	1999	There was no detectable effect of PGE2 alone on IL-11 levels; however, the suppression of IL-11 production by indomethacin was almost completely reversed by addition of PGE2.	Dinoprostone	169-173	interleukin 11	Homo sapiens	90-95
10542977-8	1999	In contrast, suppression of IL-11 production by indomenthacin was not reversed by addition of thromboxane B2 and carbocyclic thromboxane A2.	indomenthacin	48-61	interleukin 11	Homo sapiens	28-33
10542977-9	1999	In addition, dexamethasone completely suppressed IL-11 production and downregulated IL-11 mRNA.	Dexamethasone	13-26	interleukin 11	Homo sapiens	49-54
10542977-9	1999	In addition, dexamethasone completely suppressed IL-11 production and downregulated IL-11 mRNA.	Dexamethasone	13-26	interleukin 11	Homo sapiens	84-89
10542977-10	1999	These results suggest that endogenous PGE2 acts as an autocrine stimulus for IL-11 production by human lung fibroblasts activated by IL-1 alpha and TGF-beta.	Dinoprostone	38-42	interleukin 11	Homo sapiens	77-82
9887070-0	1999	Dexamethasone regulation of lung epithelial cell and fibroblast interleukin-11 production.	Dexamethasone	0-13	interleukin 11	Homo sapiens	64-78
10419646-2	1999	We show here that the reduction of LPL activity in J774.2 macrophages observed in the presence of interleukin (IL-1) and IL-11 was sensitive to herbimycin A, with the effect of LPS, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) on LPL activity being sensitive to both herbimycin A and wortmannin.	herbimycin	144-156	interleukin 11	Homo sapiens	121-126
10407498-7	1999	IL-1 alpha, transforming growth factor-beta (TGF beta) and, to a lesser extent, tumor necrosis factor-alpha (TNF alpha) stimulated the IL-11 production by VSMC, and the stimulatory effects of IL-1 alpha and TGF beta on IL-11 production were dose-dependent.	vsmc	155-159	interleukin 11	Homo sapiens	135-140
10407498-8	1999	IL-1 alpha and TNF alpha synergistically augmented TGF beta-stimulated IL-11 production by VSMC.	vsmc	91-95	interleukin 11	Homo sapiens	71-76
10381910-1	1999	BACKGROUND & AIMS: Recombinant human interleukin 11 (rhIL-11) is a cytokine with thrombocytopoietic activity and anti-inflammatory and mucosal protective effects.	Adenosine Monophosphate	12-15	interleukin 11	Homo sapiens	41-55
10210767-3	1999	Preliminary results have shown that antisense oligonucleotides (anti-ICAM), anti-cytokine antibodies (anti-TNF) or recombinant human cytokines (IL-10 or IL-11) are effective in some patients with Crohn"s disease refractory to steroids.	Steroids	226-234	interleukin 11	Homo sapiens	153-158
9887070-3	1999	Dexamethasone inhibited the levels of basal and TGF-beta1-stimulated IL-11 elaboration in a dose-dependent fashion.	Dexamethasone	0-13	interleukin 11	Homo sapiens	69-74
9887070-4	1999	In the setting of TGF-beta1 stimulation, dexamethasone caused a >90% decrease in IL-11 production at 10(-6) M, a 50% decrease in IL-11 production at approximately 1 x 10(-9) M, and significant inhibition at 10(-10) M. This dexamethasone-induced inhibition was reversed by the glucocorticoid-receptor antagonist RU-486.	Dexamethasone	41-54	interleukin 11	Homo sapiens	84-89
9887070-4	1999	In the setting of TGF-beta1 stimulation, dexamethasone caused a >90% decrease in IL-11 production at 10(-6) M, a 50% decrease in IL-11 production at approximately 1 x 10(-9) M, and significant inhibition at 10(-10) M. This dexamethasone-induced inhibition was reversed by the glucocorticoid-receptor antagonist RU-486.	Dexamethasone	41-54	interleukin 11	Homo sapiens	132-137
9887070-5	1999	Dexamethasone also inhibited respiratory syncytial virus, rhinovirus, and TGF-beta1-stimulated IL-11 production by MRC-5 lung fibroblasts.	Dexamethasone	0-13	interleukin 11	Homo sapiens	95-100
9887070-6	1999	In all cases, dexamethasone caused comparable changes in IL-11 mRNA accumulation.	Dexamethasone	14-27	interleukin 11	Homo sapiens	57-62
9887070-7	1999	Nuclear run-on studies demonstrated that dexamethasone caused a modest (</=40%) decrease in TGF-beta1-stimulated IL-11 gene transcription.	Dexamethasone	41-54	interleukin 11	Homo sapiens	116-121
9887070-8	1999	Actinomycin D pulse-chase experiments demonstrated that dexamethasone simultaneously destabilized IL-11 mRNA.	Dactinomycin	0-13	interleukin 11	Homo sapiens	98-103
9887070-8	1999	Actinomycin D pulse-chase experiments demonstrated that dexamethasone simultaneously destabilized IL-11 mRNA.	Dexamethasone	56-69	interleukin 11	Homo sapiens	98-103
9887070-9	1999	Dexamethasone also inhibited TGF-beta1-stimulated IL-11 promoter-driven luciferase activity but did not diminish activator protein-1 binding to IL-11 promoter sequences.	Dexamethasone	0-13	interleukin 11	Homo sapiens	50-55
10331181-3	1999	The transfected cells selected with G418 secreted IL-11 constitutively over the range of 32.4 +/- 10.5 units/ml to 76.6 +/- 18.4 units/ml, which could be inhibited by an IL-11 neutralizing MAb up to 80%.	antibiotic G 418	36-40	interleukin 11	Homo sapiens	50-55
10331181-3	1999	The transfected cells selected with G418 secreted IL-11 constitutively over the range of 32.4 +/- 10.5 units/ml to 76.6 +/- 18.4 units/ml, which could be inhibited by an IL-11 neutralizing MAb up to 80%.	antibiotic G 418	36-40	interleukin 11	Homo sapiens	170-175
9648226-6	1998	N-terminal sequencing of the 23-kDa protein showed that NIa specifically cleaved the fusion protein at Gln-Ala, producing Ala-hIL-11.	Glutamine	103-106	interleukin 11	Homo sapiens	126-132
18020592-7	1998	The recommended adult dosage of subcutaneous oprelvekin is 50 microg/kg once daily, administered until the platelet count is >or=50 000/microl after the expected nadir, but for not more than 21 days per chemotherapy cycle.	nadir	165-170	interleukin 11	Homo sapiens	45-55
9572469-7	1998	When IL-11 was added to the calvaria culture, the concentrations of prostaglandin E2 (PGE2) was elevated.	Dinoprostone	68-84	interleukin 11	Homo sapiens	5-10
9572469-7	1998	When IL-11 was added to the calvaria culture, the concentrations of prostaglandin E2 (PGE2) was elevated.	Dinoprostone	86-90	interleukin 11	Homo sapiens	5-10
9572469-8	1998	Pretreatment of calvaria with cyclooxygenases inhibitors (e.g., indomethacin, NS-398, and dexamethasone) suppressed the production of PGE2 and the bone resorption induced by IL-11.	Indomethacin	64-76	interleukin 11	Homo sapiens	174-179
9572469-8	1998	Pretreatment of calvaria with cyclooxygenases inhibitors (e.g., indomethacin, NS-398, and dexamethasone) suppressed the production of PGE2 and the bone resorption induced by IL-11.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	78-84	interleukin 11	Homo sapiens	174-179
9572469-8	1998	Pretreatment of calvaria with cyclooxygenases inhibitors (e.g., indomethacin, NS-398, and dexamethasone) suppressed the production of PGE2 and the bone resorption induced by IL-11.	Dexamethasone	90-103	interleukin 11	Homo sapiens	174-179
9572469-8	1998	Pretreatment of calvaria with cyclooxygenases inhibitors (e.g., indomethacin, NS-398, and dexamethasone) suppressed the production of PGE2 and the bone resorption induced by IL-11.	Dinoprostone	134-138	interleukin 11	Homo sapiens	174-179
9572469-10	1998	These results indicate that IL-11 promotes bone resorption through a PGE2 synthesis-dependent mechanism and that cyclooxygenases inhibitors could be interesting drugs to suppress IL-11-mediated osteolytic bone metastasis of cancer cells.	Dinoprostone	69-73	interleukin 11	Homo sapiens	28-33
9619855-5	1998	The cyclic AMP inducer, forskolin, and the activator of protein kinase C, phorbol 12-myristate 13-acetate, also stimulated the production of Il-11.	Cyclic AMP	4-14	interleukin 11	Homo sapiens	141-146
9619855-5	1998	The cyclic AMP inducer, forskolin, and the activator of protein kinase C, phorbol 12-myristate 13-acetate, also stimulated the production of Il-11.	Colforsin	24-33	interleukin 11	Homo sapiens	141-146
9619855-5	1998	The cyclic AMP inducer, forskolin, and the activator of protein kinase C, phorbol 12-myristate 13-acetate, also stimulated the production of Il-11.	Tetradecanoylphorbol Acetate	74-105	interleukin 11	Homo sapiens	141-146
9811056-0	1998	Interleukin-1alpha and tumor necrosis factor alpha synergistically stimulate prostaglandin E2-dependent production of interleukin-11 in rheumatoid synovial fibroblasts.	Dinoprostone	77-93	interleukin 11	Homo sapiens	118-132
9811056-12	1998	CONCLUSION: These findings suggest that IL-1alpha and TNFalpha synergistically stimulate the production of IL-11 via their effects on PGE2 production in the rheumatoid joint, and that atypical PKC may be another target for down-regulation of IL-11, the bone resorption-associated cytokine.	Dinoprostone	134-138	interleukin 11	Homo sapiens	107-112
9648226-6	1998	N-terminal sequencing of the 23-kDa protein showed that NIa specifically cleaved the fusion protein at Gln-Ala, producing Ala-hIL-11.	Alanine	107-110	interleukin 11	Homo sapiens	126-132
9566801-0	1998	Differential inhibitory effects of indomethacin, dexamethasone, and interferon-gamma (IFN-gamma) on IL-11 production by rheumatoid synovial cells.	Indomethacin	35-47	interleukin 11	Homo sapiens	100-105
9553159-0	1998	A polymorphic dinucleotide repeat in the 5" flanking region of the human interleukin 11 (IL11) gene.	Dinucleoside Phosphates	14-26	interleukin 11	Homo sapiens	73-87
9553159-0	1998	A polymorphic dinucleotide repeat in the 5" flanking region of the human interleukin 11 (IL11) gene.	Dinucleoside Phosphates	14-26	interleukin 11	Homo sapiens	89-93
9566801-5	1998	Indomethacin inhibited the production of IL-11 by about 55%.	Indomethacin	0-12	interleukin 11	Homo sapiens	41-46
9566801-6	1998	Prostaglandin E2 (PGE2) completely prevented the inhibition, suggesting that IL-11 production by fresh RSC was in part mediated by PGE2.	Dinoprostone	0-16	interleukin 11	Homo sapiens	77-82
9566801-6	1998	Prostaglandin E2 (PGE2) completely prevented the inhibition, suggesting that IL-11 production by fresh RSC was in part mediated by PGE2.	Dinoprostone	18-22	interleukin 11	Homo sapiens	77-82
9566801-6	1998	Prostaglandin E2 (PGE2) completely prevented the inhibition, suggesting that IL-11 production by fresh RSC was in part mediated by PGE2.	rsc	103-106	interleukin 11	Homo sapiens	77-82
9566801-6	1998	Prostaglandin E2 (PGE2) completely prevented the inhibition, suggesting that IL-11 production by fresh RSC was in part mediated by PGE2.	Dinoprostone	131-135	interleukin 11	Homo sapiens	77-82
9566801-7	1998	Dexamethasone inhibited the production of IL-11 by more than 80%.	Dexamethasone	0-13	interleukin 11	Homo sapiens	42-47
9566801-10	1998	These results suggest that the production of IL-11 by rheumatoid synovia was differentially regulated by PGE2 and IFN-gamma, and that treatment with indomethacin or dexamethasone decreased the level of IL-11 at inflammatory joints in patients with RA.	Dinoprostone	105-109	interleukin 11	Homo sapiens	45-50
9566801-10	1998	These results suggest that the production of IL-11 by rheumatoid synovia was differentially regulated by PGE2 and IFN-gamma, and that treatment with indomethacin or dexamethasone decreased the level of IL-11 at inflammatory joints in patients with RA.	Indomethacin	149-161	interleukin 11	Homo sapiens	45-50
9566801-10	1998	These results suggest that the production of IL-11 by rheumatoid synovia was differentially regulated by PGE2 and IFN-gamma, and that treatment with indomethacin or dexamethasone decreased the level of IL-11 at inflammatory joints in patients with RA.	Indomethacin	149-161	interleukin 11	Homo sapiens	202-207
9566801-10	1998	These results suggest that the production of IL-11 by rheumatoid synovia was differentially regulated by PGE2 and IFN-gamma, and that treatment with indomethacin or dexamethasone decreased the level of IL-11 at inflammatory joints in patients with RA.	Dexamethasone	165-178	interleukin 11	Homo sapiens	45-50
9566801-10	1998	These results suggest that the production of IL-11 by rheumatoid synovia was differentially regulated by PGE2 and IFN-gamma, and that treatment with indomethacin or dexamethasone decreased the level of IL-11 at inflammatory joints in patients with RA.	Dexamethasone	165-178	interleukin 11	Homo sapiens	202-207
18031104-2	1997	Recombinant human IL-11 (rhIL-11; oprelvekin) is produced in Escherichia coli and differs from the naturally occurring protein only in the absence of the amino-terminal proline residue.	Proline	169-176	interleukin 11	Homo sapiens	18-23
27416479-5	1998	When TPA/A23187 were added to the culture of bone marrow stromal cell line KM102, IL-11 transcripts were rapidly upregulated.	Tetradecanoylphorbol Acetate	5-8	interleukin 11	Homo sapiens	82-87
27416479-5	1998	When TPA/A23187 were added to the culture of bone marrow stromal cell line KM102, IL-11 transcripts were rapidly upregulated.	Calcimycin	9-15	interleukin 11	Homo sapiens	82-87
18031104-2	1997	Recombinant human IL-11 (rhIL-11; oprelvekin) is produced in Escherichia coli and differs from the naturally occurring protein only in the absence of the amino-terminal proline residue.	Proline	169-176	interleukin 11	Homo sapiens	34-44
9548510-1	1997	Recombinant human IL-11 (rhIL-11) is an anti-inflammatory cytokine that can reduce the production of inflammatory mediators such as TNF-alpha, IL-1beta, IL-12, IL-6, and nitric oxide.	Nitric Oxide	170-182	interleukin 11	Homo sapiens	18-23
9169347-5	1997	Agonists for protein kinase A (PKA) (forskolin), and protein kinase C (PKC) (phorbol 12-myristate 13-acetate; PMA) also stimulated IL-6/IL-11 production.	Colforsin	37-46	interleukin 11	Homo sapiens	136-141
9363868-0	1997	Randomized placebo-controlled study of recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and doxorubicin.	Cyclophosphamide	177-193	interleukin 11	Homo sapiens	57-71
9363868-0	1997	Randomized placebo-controlled study of recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and doxorubicin.	Doxorubicin	198-209	interleukin 11	Homo sapiens	57-71
9245489-0	1997	Mitigating effects of interleukin 11 on consecutive courses of 5-fluorouracil-induced ulcerative mucositis in hamsters.	Fluorouracil	63-77	interleukin 11	Homo sapiens	22-36
9245489-3	1997	Recently, we reported that recombinant human(rh) interleukin 11 (IL-11) favourably modified the course of mucositis following a single stomatotoxic regimen of 5-fluorouracil in hamsters.	Fluorouracil	159-173	interleukin 11	Homo sapiens	49-63
9245489-3	1997	Recently, we reported that recombinant human(rh) interleukin 11 (IL-11) favourably modified the course of mucositis following a single stomatotoxic regimen of 5-fluorouracil in hamsters.	Fluorouracil	159-173	interleukin 11	Homo sapiens	65-70
9169347-5	1997	Agonists for protein kinase A (PKA) (forskolin), and protein kinase C (PKC) (phorbol 12-myristate 13-acetate; PMA) also stimulated IL-6/IL-11 production.	Tetradecanoylphorbol Acetate	77-108	interleukin 11	Homo sapiens	136-141
9169347-6	1997	Rp-diastereoisomer of adenosine cyclic 3",5"-phosphorothioate (Rp-cAMPS) and H-8, inhibitors of PKA, significantly inhibited PTH-stimulated IL-6/IL-11 production, but did not inhibit IL-1-stimulated IL-6/IL-11 production.	adenosine cyclic 3",5"-phosphorothioate	22-61	interleukin 11	Homo sapiens	145-150
9169347-6	1997	Rp-diastereoisomer of adenosine cyclic 3",5"-phosphorothioate (Rp-cAMPS) and H-8, inhibitors of PKA, significantly inhibited PTH-stimulated IL-6/IL-11 production, but did not inhibit IL-1-stimulated IL-6/IL-11 production.	adenosine cyclic 3",5"-phosphorothioate	22-61	interleukin 11	Homo sapiens	204-209
9169347-6	1997	Rp-diastereoisomer of adenosine cyclic 3",5"-phosphorothioate (Rp-cAMPS) and H-8, inhibitors of PKA, significantly inhibited PTH-stimulated IL-6/IL-11 production, but did not inhibit IL-1-stimulated IL-6/IL-11 production.	N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide	77-80	interleukin 11	Homo sapiens	145-150
9169347-6	1997	Rp-diastereoisomer of adenosine cyclic 3",5"-phosphorothioate (Rp-cAMPS) and H-8, inhibitors of PKA, significantly inhibited PTH-stimulated IL-6/IL-11 production, but did not inhibit IL-1-stimulated IL-6/IL-11 production.	N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide	77-80	interleukin 11	Homo sapiens	204-209
9169347-7	1997	In contrast, staurosporine and calphostin C, inhibitors of PKC, suppressed IL-1-stimulated, but not PTH-stimulated, IL-6/ IL-11 production.	calphostin C	31-43	interleukin 11	Homo sapiens	122-127
8947585-4	1996	IL-11 in combination with IL-3 and GM-CSF markedly increased CFU-C colony growth pre- and post-ARA-C or Eilatin incubation from CML and normal individual bone marrow (BM) cells.	Cytarabine	95-100	interleukin 11	Homo sapiens	0-5
8871663-0	1996	Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production.	Nitric Oxide	125-137	interleukin 11	Homo sapiens	18-23
8947585-4	1996	IL-11 in combination with IL-3 and GM-CSF markedly increased CFU-C colony growth pre- and post-ARA-C or Eilatin incubation from CML and normal individual bone marrow (BM) cells.	eilatine	104-111	interleukin 11	Homo sapiens	0-5
8947585-6	1996	A decrease in BCR/ABL fusion product was observed (by FISH analysis) after incubation of BM cells from CML patients in liquid culture for 7 days with 10(-9) M ARA-C or 10(-7) M Eilatin in the presence of IL-11 alone or in combination with other cytokines.	Cytarabine	159-164	interleukin 11	Homo sapiens	204-209
8947585-6	1996	A decrease in BCR/ABL fusion product was observed (by FISH analysis) after incubation of BM cells from CML patients in liquid culture for 7 days with 10(-9) M ARA-C or 10(-7) M Eilatin in the presence of IL-11 alone or in combination with other cytokines.	eilatine	177-184	interleukin 11	Homo sapiens	204-209
8690043-4	1996	In Northern blot experiments, expression of IL-11 mRNA was reduced in the presence of INF-alpha; this inhibiton was prevented by the addition of cycloheximide.	Cycloheximide	145-158	interleukin 11	Homo sapiens	44-49
8769290-0	1996	Protection by recombinant human interleukin-11 against experimental TNB-induced colitis in rats.	Trinitrobenzenesulfonic Acid	68-71	interleukin 11	Homo sapiens	32-46
8769290-1	1996	The potential effect of recombinant human interleukin-11 (rhIL-11) on trinitrobenzene sulfonic acid (TNB)-induced colitis was investigated in rats.	Trinitrobenzenesulfonic Acid	70-99	interleukin 11	Homo sapiens	42-56
8735608-6	1996	Moreover, in these cells, expression of IL-11 transcripts was induced 3-fold by addition of estradiol to the culture medium.	Estradiol	92-101	interleukin 11	Homo sapiens	40-45
8536785-7	1996	IL-1 alpha-induced GM-CSF, IL-1 beta, IL-6, IL-11, and LIF mRNA levels were reduced by the addition of dexamethasone, whereas dexamethasone had no influence on the amounts of IL-1 alpha-induced G-CSF mRNA.	Dexamethasone	103-116	interleukin 11	Homo sapiens	44-49
8600162-5	1996	Exposure of cells in growth medium to dexamethasone resulted in a decrease in the expression of LIF, IL-6, and IL-11.	Dexamethasone	38-51	interleukin 11	Homo sapiens	111-116
8599453-6	1995	Less abundant mRNAs, such as those encoding interleukin-11 or the T-cell receptor beta-chain, could be detected by Southern blotting and hybridization with labeled oligonucleotide probes or by cloning and sequencing.	Oligonucleotides	164-179	interleukin 11	Homo sapiens	44-58
8549788-2	1995	The growth of some of these HMCL can also be supported by IL-11.	hmcl	28-32	interleukin 11	Homo sapiens	58-63
8071352-4	1994	We also determined whether retinoic acid (RA) altered this IL-11 production.	Tretinoin	27-40	interleukin 11	Homo sapiens	59-64
8547068-6	1995	In eight additional AML cases the number of S-phase leukaemic cells induced by IL-11 was determined by the bromodeoxyuridine (BRDU) incorporation assay after 3d of liquid culture.	Bromodeoxyuridine	107-124	interleukin 11	Homo sapiens	79-84
8547068-6	1995	In eight additional AML cases the number of S-phase leukaemic cells induced by IL-11 was determined by the bromodeoxyuridine (BRDU) incorporation assay after 3d of liquid culture.	Bromodeoxyuridine	126-130	interleukin 11	Homo sapiens	79-84
7486676-0	1995	Interleukin-11 induces tyrosine phosphorylation, and c-jun and c-fos mRNA expression in human K562 and U937 cells.	Tyrosine	23-31	interleukin 11	Homo sapiens	0-14
7501271-3	1995	Using RT-PCR, Northern blotting, and ELISA we demonstrated that the human U373 and U87 glioblastoma cell lines expressed IL-11 and its encoding mRNA when stimulated with IL-1 beta, phorbol ester, and calcium ionophore.	Phorbol Esters	181-194	interleukin 11	Homo sapiens	121-126
7501271-3	1995	Using RT-PCR, Northern blotting, and ELISA we demonstrated that the human U373 and U87 glioblastoma cell lines expressed IL-11 and its encoding mRNA when stimulated with IL-1 beta, phorbol ester, and calcium ionophore.	Calcium	200-207	interleukin 11	Homo sapiens	121-126
7668526-0	1995	Alanine-scanning mutagenesis of human interleukin-11: identification of regions important for biological activity.	Alanine	0-7	interleukin 11	Homo sapiens	38-52
7668526-1	1995	We have identified functionally important regions of human interleukin-11 (hIL-11) by means of alanine-scanning mutagenesis.	Alanine	95-102	interleukin 11	Homo sapiens	59-73
7668526-1	1995	We have identified functionally important regions of human interleukin-11 (hIL-11) by means of alanine-scanning mutagenesis.	Alanine	95-102	interleukin 11	Homo sapiens	75-81
7527667-6	1994	Phorbol myristate acetate (PMA) induced a twofold greater increase in IL-11 mRNA expression in neonatal fibroblasts (NFb) compared with adult fibroblasts (AFb), and a 3.6-fold greater increase in HUVEC than human adult aorta endothelial cells (HAEC) by Northern blot analysis.	Tetradecanoylphorbol Acetate	0-25	interleukin 11	Homo sapiens	70-75
7527667-6	1994	Phorbol myristate acetate (PMA) induced a twofold greater increase in IL-11 mRNA expression in neonatal fibroblasts (NFb) compared with adult fibroblasts (AFb), and a 3.6-fold greater increase in HUVEC than human adult aorta endothelial cells (HAEC) by Northern blot analysis.	Tetradecanoylphorbol Acetate	27-30	interleukin 11	Homo sapiens	70-75
7527667-7	1994	PMA also induced a threefold greater increase in IL-11 protein production in NFb than AFb.	Tetradecanoylphorbol Acetate	0-3	interleukin 11	Homo sapiens	49-54
7963541-3	1994	To further understand the biology of histamine and IL-11, we determined whether histamine regulates the production of IL-11 by human lung fibroblasts.	Histamine	80-89	interleukin 11	Homo sapiens	118-123
7963541-4	1994	Histamine was a weak stimulator of IL-11 production.	Histamine	0-9	interleukin 11	Homo sapiens	35-40
7963541-10	1994	These studies demonstrate that histamine is an important regulator of fibroblast IL-11 production, that histamine interacts with TGF-beta 1 in the induction of this cytokine, and that this interaction is mediated, to a great extent, by a pretranslational mechanism that is dependent on H1 receptors and a calcium/calmodulin-dependent activation pathway.	Histamine	31-40	interleukin 11	Homo sapiens	81-86
8069861-0	1994	Increased survival and multilineage hematopoietic protection from delayed and severe myelosuppressive effects of a nitrosourea with recombinant interleukin-11.	Nitrosourea Compounds	115-126	interleukin 11	Homo sapiens	144-158
8069861-5	1994	In this model, we demonstrate that interleukin-11, a stromal-derived hematopoietic growth factor with pleiotropic effects in a number of preclinical ablation models, markedly diminishes nitrosourea-induced pancytopenia and leads to a significant reduction in chemotherapy-related mortality.	Nitrosourea Compounds	186-197	interleukin 11	Homo sapiens	35-49
8069861-6	1994	These data suggest that interleukin-11 could allow significant dose intensification in the treatment of tumors which are nitrosourea sensitive.	Nitrosourea Compounds	121-132	interleukin 11	Homo sapiens	24-38
7816067-4	1995	The production of interleukin-6 by stromal osteoblastic cells, as well as the responsiveness of bone marrow cells to cytokines such as interleukin-6 and interleukin-11, is regulated by sex steroids.	Steroids	189-197	interleukin 11	Homo sapiens	153-167
8071352-4	1994	We also determined whether retinoic acid (RA) altered this IL-11 production.	Tretinoin	42-44	interleukin 11	Homo sapiens	59-64
7532057-6	1994	The human IL-11 gene is localized at 19q13.3-13.4, and codes 199 amino acids and 23 kDa with no N glycosylation.	Nitrogen	96-97	interleukin 11	Homo sapiens	10-15
7518681-4	1994	We further show that IL-11, a cytokine that signals via the gp130 subunit of the IL-6 receptor, induced similar profiles of JAK-TYK tyrosine phosphorylation as IL-6 in B9E and T10D cells.	Tyrosine	132-140	interleukin 11	Homo sapiens	21-26
8383296-4	1993	The cytokine interleukin(IL)-11 induces expression of action potentials that are insensitive to tetrodotoxin, which is indicative of developmentally immature sodium channels.	Tetrodotoxin	96-108	interleukin 11	Homo sapiens	13-31
8123841-0	1994	Recombinant human interleukin-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin.	Carboplatin	150-161	interleukin 11	Homo sapiens	18-32
8111307-5	1993	Like other cytokines such as IL-6, leukemia inhibitory factor (LIF), oncostatin M (ONC) and ciliary neurotrophic factor (CNTF), IL-11 has been shown to utilize IL-6 signal transducer, gp130.	oncostatin	69-79	interleukin 11	Homo sapiens	128-133
8111307-7	1993	Studies of protein tyrosine phosphorylation, primary response gene expression and signaling molecules known to be important in transducing mitogenic signals have suggested that there are convergent and divergent points along the signal transduction pathways utilized by IL-11, IL-6, LIF and ONC.	Tyrosine	19-27	interleukin 11	Homo sapiens	270-275
8408003-4	1993	Activation of protein kinase C by phorbol esters and inhibition of protein synthesis by cyclohexamide increased IL-11 transcripts, whereas calcium ionophore A23817 or dibutyryl cyclic AMP had no effect.	4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]piperidine-2,6-dione	88-101	interleukin 11	Homo sapiens	112-117
8408003-5	1993	Immunoprecipitations revealed the synthesis of IL-11 protein in response to TGF-beta 1, IL-1 beta, as well as phorbol 12-myristate 13-acetate, and a synergistic action of TGF-beta 1 and IL-1 beta was observed.	Tetradecanoylphorbol Acetate	110-141	interleukin 11	Homo sapiens	47-52
8133053-7	1994	A23187, however, did induce IL-11 mRNA accumulation and W7 and TFP did reverse the synergistic stimulation caused by rIL-1 and TGF-beta in combination.	Calcimycin	0-6	interleukin 11	Homo sapiens	28-33
8104229-1	1993	Post 5-fluorouracil-treated murine bone marrow cells infected with a recombinant retrovirus (murine stem cell virus-interleukin 11 [MSCV-IL-11]) bearing a human IL-11 gene were transplanted into lethally irradiated syngeneic mice.	Fluorouracil	5-19	interleukin 11	Homo sapiens	137-142
8104229-1	1993	Post 5-fluorouracil-treated murine bone marrow cells infected with a recombinant retrovirus (murine stem cell virus-interleukin 11 [MSCV-IL-11]) bearing a human IL-11 gene were transplanted into lethally irradiated syngeneic mice.	Fluorouracil	5-19	interleukin 11	Homo sapiens	161-166
8360477-5	1993	The results showed that IL-11 and IL-6 can both stimulate cell proliferation, induce similar pattern of protein tyrosine phosphorylation, and activate the same proto-oncogene (junB) expression in TF-1 cells.	Tyrosine	112-120	interleukin 11	Homo sapiens	24-29
8401258-4	1993	At the molecular level, IL-11 is unique, containing no asparagine-linked glycosylation sites and no cysteine residues.	Asparagine	55-65	interleukin 11	Homo sapiens	24-29
8401258-4	1993	At the molecular level, IL-11 is unique, containing no asparagine-linked glycosylation sites and no cysteine residues.	Cysteine	100-108	interleukin 11	Homo sapiens	24-29
8427997-5	1993	The growth of the cells was inhibited by anti-IL-11 antibody and IL-11 antisense oligonucleotides.	Oligonucleotides	81-97	interleukin 11	Homo sapiens	65-70
1307488-4	1992	Adipogenesis inhibitory factor (AGIF) was cloned from the human bone marrow-derived stromal cell line KM-102.	km-102	102-108	interleukin 11	Homo sapiens	0-30
1292471-6	1992	Results from protein tyrosine phosphorylation and immediate response gene expression suggest that there are convergent and divergent points along the signal transduction pathways utilized by IL-6 or IL-11.	Tyrosine	21-29	interleukin 11	Homo sapiens	199-204
1307488-4	1992	Adipogenesis inhibitory factor (AGIF) was cloned from the human bone marrow-derived stromal cell line KM-102.	km-102	102-108	interleukin 11	Homo sapiens	32-36