PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
12108552-1	2002	We explored the unique substrate specificity of the primary S, subsite of human urinary kallikrein (hK1), which accepts both Phe or Arg synthesizing and assaying peptides derived from Phenylacetyl-Phe-Ser-Arg-EDDnp, a previously described inhibitor with analgesic and anti-inflammatory activities [Emim et al., Br.	Phenylalanine	125-128	keratin 1	Homo sapiens	100-103
12108552-1	2002	We explored the unique substrate specificity of the primary S, subsite of human urinary kallikrein (hK1), which accepts both Phe or Arg synthesizing and assaying peptides derived from Phenylacetyl-Phe-Ser-Arg-EDDnp, a previously described inhibitor with analgesic and anti-inflammatory activities [Emim et al., Br.	Arginine	132-135	keratin 1	Homo sapiens	100-103
12108552-1	2002	We explored the unique substrate specificity of the primary S, subsite of human urinary kallikrein (hK1), which accepts both Phe or Arg synthesizing and assaying peptides derived from Phenylacetyl-Phe-Ser-Arg-EDDnp, a previously described inhibitor with analgesic and anti-inflammatory activities [Emim et al., Br.	phenylacetyl-phe-ser-arg-eddnp	184-214	keratin 1	Homo sapiens	100-103
22896885-9	2002	Geometrical isomers of acitretin showed different effects on differentiation of human epidermal keratinocytes; expression of keratinocyte differentiation markers, keratin 1 and keratin 10, were suppressed more strongly by 9-cis-acitretin and 13-cis-acitretin as compared to all-trans-acitretin or 9, 13-di-cis-acitretin.	Acitretin	23-32	keratin 1	Homo sapiens	163-172
11982762-8	2002	Direct sequencing of the keratin 1 gene revealed a frameshift mutation in exon 9 that leads to the partial loss of the glycine loop motif in the V2 domain and the gain of a novel 70 amino acid peptide.	Glycine	119-126	keratin 1	Homo sapiens	25-34
22896885-9	2002	Geometrical isomers of acitretin showed different effects on differentiation of human epidermal keratinocytes; expression of keratinocyte differentiation markers, keratin 1 and keratin 10, were suppressed more strongly by 9-cis-acitretin and 13-cis-acitretin as compared to all-trans-acitretin or 9, 13-di-cis-acitretin.	13-cis Acitretin	222-237	keratin 1	Homo sapiens	163-172
11800601-2	2002	The structure of the fac-[Fe(II)(CN)(3)(CO)(3)](-) (1) anion was established by the X-ray crystal structures of K-1 and [Ph(4)As]-1.H(2)O.	ammonium ferrous sulfate	26-32	keratin 1	Homo sapiens	112-115
11800601-2	2002	The structure of the fac-[Fe(II)(CN)(3)(CO)(3)](-) (1) anion was established by the X-ray crystal structures of K-1 and [Ph(4)As]-1.H(2)O.	co)(3)	40-46	keratin 1	Homo sapiens	112-115
11558869-8	2001	Five out of 6 patients with KRT10 mutations benefited from treatment with oral acitretin (5-25mg/day) or topical tretinoin/tazarotene, but none of the patients with KRT1 mutations derived any benefit.	Acitretin	79-88	keratin 1	Homo sapiens	28-32
11876525-4	2002	Both URA liposomes and retinoic acid decreased markers of keratinocyte differentiation (keratin 1, keratin 10 and involucrin) in cultured NHEK.	Uracil	5-8	keratin 1	Homo sapiens	88-97
11876525-4	2002	Both URA liposomes and retinoic acid decreased markers of keratinocyte differentiation (keratin 1, keratin 10 and involucrin) in cultured NHEK.	Tretinoin	23-36	keratin 1	Homo sapiens	88-97
11532311-8	2001	First order release constant K(1) was found to be quantitatively related to the reciprocal of the cube root of both mean polymer particle size and number of polymer particles in the matrix.	Polymers	121-128	keratin 1	Homo sapiens	29-33
11532311-8	2001	First order release constant K(1) was found to be quantitatively related to the reciprocal of the cube root of both mean polymer particle size and number of polymer particles in the matrix.	Polymers	157-164	keratin 1	Homo sapiens	29-33
11531804-5	2001	We report a new amino acid substitution mutation in codon 155 of KRT1 (valine to aspartic acid) in the conserved H1 domain of the protein in the patient with BCIE.	Valine	71-77	keratin 1	Homo sapiens	65-69
11531804-5	2001	We report a new amino acid substitution mutation in codon 155 of KRT1 (valine to aspartic acid) in the conserved H1 domain of the protein in the patient with BCIE.	Aspartic Acid	81-94	keratin 1	Homo sapiens	65-69
11558869-8	2001	Five out of 6 patients with KRT10 mutations benefited from treatment with oral acitretin (5-25mg/day) or topical tretinoin/tazarotene, but none of the patients with KRT1 mutations derived any benefit.	Tretinoin	113-122	keratin 1	Homo sapiens	28-32
11558869-8	2001	Five out of 6 patients with KRT10 mutations benefited from treatment with oral acitretin (5-25mg/day) or topical tretinoin/tazarotene, but none of the patients with KRT1 mutations derived any benefit.	tazarotene	123-133	keratin 1	Homo sapiens	28-32
11558869-13	2001	Retinoid therapy is particularly effective in patients with KRT10 mutations possibly because they are less vulnerable to a down-regulation of K2e, potentially functioning as a substitute for the mutated protein in patients with KRT1 mutations.	Retinoids	0-8	keratin 1	Homo sapiens	60-64
11318645-4	2001	However, Abz-F-Ama-S-R-Q-EDDnp inhibited hK1 with a K(i) of 50 nM with high specificity compared to human plasma kallikrein, thrombin, plasmin, and trypsin.	abz-f-ama-s-r-q-eddnp	9-30	keratin 1	Homo sapiens	41-44
11318645-5	2001	The Abz-G-F-S-P-F-X-S-S-R-P-Q-EDDnp series were more susceptible to hK1, although the peptides with Gnf, Pya, and Ama were resistant to it.	abz-g-f-s-p-f-x-s-s-r-p-q-eddnp	4-35	keratin 1	Homo sapiens	68-71
11286071-5	2001	The chemical composition of the saline ground water from the two Cenomanian subaquifers (K1 and K2) point to a single saline source with Na/Cl approximately 0.5 and Br/Cl approximately 7 x 10(-3).	Sodium Chloride	32-38	keratin 1	Homo sapiens	89-98
10926513-1	2000	The internal motions of the backbone nitrogen atoms of the kringle 1 domain of human plasminogen (K1(Pg)) were examined in the absence and presence of the ligand, epsilon-aminocaproic acid.	Nitrogen	37-45	keratin 1	Homo sapiens	98-104
11151026-3	2001	The data indicate that the inhibition of hK1 by 4-aminobenzamidine and benzamidine is linear competitive, while the inhibition by 4-nitroaniline and aniline is linear mixed, with the inhibitor being able to bind both to the free enzyme with a dissociation constant Ki yielding an EI complex, and to the ES complex with a dissociation constant Ki", yielding an ESI complex.	4-aminobenzamidine	48-66	keratin 1	Homo sapiens	41-44
11151026-3	2001	The data indicate that the inhibition of hK1 by 4-aminobenzamidine and benzamidine is linear competitive, while the inhibition by 4-nitroaniline and aniline is linear mixed, with the inhibitor being able to bind both to the free enzyme with a dissociation constant Ki yielding an EI complex, and to the ES complex with a dissociation constant Ki", yielding an ESI complex.	benzamidine	55-66	keratin 1	Homo sapiens	41-44
11151026-3	2001	The data indicate that the inhibition of hK1 by 4-aminobenzamidine and benzamidine is linear competitive, while the inhibition by 4-nitroaniline and aniline is linear mixed, with the inhibitor being able to bind both to the free enzyme with a dissociation constant Ki yielding an EI complex, and to the ES complex with a dissociation constant Ki", yielding an ESI complex.	aziridine	280-282	keratin 1	Homo sapiens	41-44
11151026-3	2001	The data indicate that the inhibition of hK1 by 4-aminobenzamidine and benzamidine is linear competitive, while the inhibition by 4-nitroaniline and aniline is linear mixed, with the inhibitor being able to bind both to the free enzyme with a dissociation constant Ki yielding an EI complex, and to the ES complex with a dissociation constant Ki", yielding an ESI complex.	Einsteinium	303-305	keratin 1	Homo sapiens	41-44
11151026-7	2001	The data about the inhibition of hK1 by 4-aminobenzamidine and benzamidine help to explain previous observations that esters, anilides or chloromethyl ketone derivatives of Nalpha-substituted arginine are more sensitive substrates or inhibitors of hK1 than the corresponding lysine compounds.	4-aminobenzamidine	40-58	keratin 1	Homo sapiens	33-36
11151026-7	2001	The data about the inhibition of hK1 by 4-aminobenzamidine and benzamidine help to explain previous observations that esters, anilides or chloromethyl ketone derivatives of Nalpha-substituted arginine are more sensitive substrates or inhibitors of hK1 than the corresponding lysine compounds.	4-aminobenzamidine	40-58	keratin 1	Homo sapiens	248-251
11151026-7	2001	The data about the inhibition of hK1 by 4-aminobenzamidine and benzamidine help to explain previous observations that esters, anilides or chloromethyl ketone derivatives of Nalpha-substituted arginine are more sensitive substrates or inhibitors of hK1 than the corresponding lysine compounds.	benzamidine	47-58	keratin 1	Homo sapiens	33-36
11151026-7	2001	The data about the inhibition of hK1 by 4-aminobenzamidine and benzamidine help to explain previous observations that esters, anilides or chloromethyl ketone derivatives of Nalpha-substituted arginine are more sensitive substrates or inhibitors of hK1 than the corresponding lysine compounds.	benzamidine	47-58	keratin 1	Homo sapiens	248-251
11151026-7	2001	The data about the inhibition of hK1 by 4-aminobenzamidine and benzamidine help to explain previous observations that esters, anilides or chloromethyl ketone derivatives of Nalpha-substituted arginine are more sensitive substrates or inhibitors of hK1 than the corresponding lysine compounds.	Esters	118-124	keratin 1	Homo sapiens	33-36
11151026-7	2001	The data about the inhibition of hK1 by 4-aminobenzamidine and benzamidine help to explain previous observations that esters, anilides or chloromethyl ketone derivatives of Nalpha-substituted arginine are more sensitive substrates or inhibitors of hK1 than the corresponding lysine compounds.	Esters	118-124	keratin 1	Homo sapiens	248-251
11151026-7	2001	The data about the inhibition of hK1 by 4-aminobenzamidine and benzamidine help to explain previous observations that esters, anilides or chloromethyl ketone derivatives of Nalpha-substituted arginine are more sensitive substrates or inhibitors of hK1 than the corresponding lysine compounds.	Anilides	126-134	keratin 1	Homo sapiens	33-36
11151026-7	2001	The data about the inhibition of hK1 by 4-aminobenzamidine and benzamidine help to explain previous observations that esters, anilides or chloromethyl ketone derivatives of Nalpha-substituted arginine are more sensitive substrates or inhibitors of hK1 than the corresponding lysine compounds.	Anilides	126-134	keratin 1	Homo sapiens	248-251
11151026-7	2001	The data about the inhibition of hK1 by 4-aminobenzamidine and benzamidine help to explain previous observations that esters, anilides or chloromethyl ketone derivatives of Nalpha-substituted arginine are more sensitive substrates or inhibitors of hK1 than the corresponding lysine compounds.	1,3-Dichloroacetone	138-157	keratin 1	Homo sapiens	33-36
11151026-7	2001	The data about the inhibition of hK1 by 4-aminobenzamidine and benzamidine help to explain previous observations that esters, anilides or chloromethyl ketone derivatives of Nalpha-substituted arginine are more sensitive substrates or inhibitors of hK1 than the corresponding lysine compounds.	1,3-Dichloroacetone	138-157	keratin 1	Homo sapiens	248-251
11151026-7	2001	The data about the inhibition of hK1 by 4-aminobenzamidine and benzamidine help to explain previous observations that esters, anilides or chloromethyl ketone derivatives of Nalpha-substituted arginine are more sensitive substrates or inhibitors of hK1 than the corresponding lysine compounds.	nalpha-substituted arginine	173-200	keratin 1	Homo sapiens	33-36
11151026-7	2001	The data about the inhibition of hK1 by 4-aminobenzamidine and benzamidine help to explain previous observations that esters, anilides or chloromethyl ketone derivatives of Nalpha-substituted arginine are more sensitive substrates or inhibitors of hK1 than the corresponding lysine compounds.	nalpha-substituted arginine	173-200	keratin 1	Homo sapiens	248-251
11151026-7	2001	The data about the inhibition of hK1 by 4-aminobenzamidine and benzamidine help to explain previous observations that esters, anilides or chloromethyl ketone derivatives of Nalpha-substituted arginine are more sensitive substrates or inhibitors of hK1 than the corresponding lysine compounds.	Lysine	275-281	keratin 1	Homo sapiens	33-36
10708807-7	2000	These findings suggest that K-1 may serve as a potent inhibitor of apoptosis initiated by ETO or nitric oxide.	Nitric Oxide	97-109	keratin 1	Homo sapiens	28-31
10932278-3	2000	Previous studies showed that the ratio between the rate constants for glucose uptake and phosphorylation (K1 and k3) is reversed in the cerebellum compared with the cerebral cortex; higher K1 in the cerebellum and higher k3 in the cerebral cortex.	Glucose	70-77	keratin 1	Homo sapiens	106-115
10989461-5	2000	The dissociation constant KD, calculated from the measured values of k-1 and k+1, was found to be 2.53 x 10(-8) M. The standard thermodynamics parameters characterizing reversible DIDS binding to Band 3 protein at 0 degree C were calculated.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	180-184	keratin 1	Homo sapiens	69-80
10232403-0	1999	An asparagine to threonine substitution in the 1A domain of keratin 1: a novel mutation that causes epidermolytic hyperkeratosis.	Asparagine	3-13	keratin 1	Homo sapiens	60-69
10983416-7	2000	Level of keratin-1 (K1) mRNA was increased by 11-cis-retinoic acid and 13-cis-retinoic acid, but suppressed by 9,13-di-cis-retinoic acids while all-trans-retinoic acid and 9-cis-retinoic acid had no effect.	11-cis-Retinoic acid	46-66	keratin 1	Homo sapiens	9-18
10983416-7	2000	Level of keratin-1 (K1) mRNA was increased by 11-cis-retinoic acid and 13-cis-retinoic acid, but suppressed by 9,13-di-cis-retinoic acids while all-trans-retinoic acid and 9-cis-retinoic acid had no effect.	11-cis-Retinoic acid	46-66	keratin 1	Homo sapiens	20-22
10983416-7	2000	Level of keratin-1 (K1) mRNA was increased by 11-cis-retinoic acid and 13-cis-retinoic acid, but suppressed by 9,13-di-cis-retinoic acids while all-trans-retinoic acid and 9-cis-retinoic acid had no effect.	Isotretinoin	71-91	keratin 1	Homo sapiens	9-18
10983416-7	2000	Level of keratin-1 (K1) mRNA was increased by 11-cis-retinoic acid and 13-cis-retinoic acid, but suppressed by 9,13-di-cis-retinoic acids while all-trans-retinoic acid and 9-cis-retinoic acid had no effect.	Isotretinoin	71-91	keratin 1	Homo sapiens	20-22
10983416-7	2000	Level of keratin-1 (K1) mRNA was increased by 11-cis-retinoic acid and 13-cis-retinoic acid, but suppressed by 9,13-di-cis-retinoic acids while all-trans-retinoic acid and 9-cis-retinoic acid had no effect.	9,13-retinoic acid	111-137	keratin 1	Homo sapiens	9-18
10983416-7	2000	Level of keratin-1 (K1) mRNA was increased by 11-cis-retinoic acid and 13-cis-retinoic acid, but suppressed by 9,13-di-cis-retinoic acids while all-trans-retinoic acid and 9-cis-retinoic acid had no effect.	9,13-retinoic acid	111-137	keratin 1	Homo sapiens	20-22
10983416-7	2000	Level of keratin-1 (K1) mRNA was increased by 11-cis-retinoic acid and 13-cis-retinoic acid, but suppressed by 9,13-di-cis-retinoic acids while all-trans-retinoic acid and 9-cis-retinoic acid had no effect.	Tretinoin	148-167	keratin 1	Homo sapiens	9-18
10983416-7	2000	Level of keratin-1 (K1) mRNA was increased by 11-cis-retinoic acid and 13-cis-retinoic acid, but suppressed by 9,13-di-cis-retinoic acids while all-trans-retinoic acid and 9-cis-retinoic acid had no effect.	Tretinoin	148-167	keratin 1	Homo sapiens	20-22
10983416-7	2000	Level of keratin-1 (K1) mRNA was increased by 11-cis-retinoic acid and 13-cis-retinoic acid, but suppressed by 9,13-di-cis-retinoic acids while all-trans-retinoic acid and 9-cis-retinoic acid had no effect.	Alitretinoin	172-191	keratin 1	Homo sapiens	9-18
10983416-7	2000	Level of keratin-1 (K1) mRNA was increased by 11-cis-retinoic acid and 13-cis-retinoic acid, but suppressed by 9,13-di-cis-retinoic acids while all-trans-retinoic acid and 9-cis-retinoic acid had no effect.	Alitretinoin	172-191	keratin 1	Homo sapiens	20-22
10535755-3	1999	Since the binding protein does not bind to other steroids or vitamins, such as hydrocortisone, vitamin A, 1,25(OH)2vitamin D3, trolox (a derivative of vitamin E), and warfarin, a specific binding protein to vitamin K1 and vitamin K2 in osteoblasts was suggested.	Calcitriol	106-125	keratin 1	Homo sapiens	215-232
10479588-5	1999	The values of the rotational constants for the K = 0, A, and F states and for the K = 1, E state are in good agreement with the infrared-determined values for Ar-(28)SiH(4).	Argon	159-161	keratin 1	Homo sapiens	82-87
10387087-4	1999	ITC studies between 282 and 312 K at 20, 50, and 120 mM Na+ show that the enthalpy of duplex formation is only weakly salt concentration-dependent but is very strongly temperature-dependent, decreasing approximately linearly with increasing temperature with a heat capacity change (282-312 K) of -1.3 +/- 0.1 kcal K-1 (mol of duplex)-1.	Salts	118-122	keratin 1	Homo sapiens	314-317
10365914-3	1999	HK1.IGF1 transgenic mice, which overexpress IGF-1 in epidermis via the human keratin 1 promoter, were previously shown to be hypersensitive to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	167-203	keratin 1	Homo sapiens	77-86
10344761-4	1999	RA inhibited the growth of five of seven cell lines and also the constitutive expression of the squamous differentiation markers cytokeratin 1 and transglutaminase I in all cell lines.	Tretinoin	0-2	keratin 1	Homo sapiens	129-142
10191281-1	1999	We have explored in detail the determinants of specificity for the hydrolysis by human tissue kallikrein (hK1) of substrates containing the Phe-Phe amino acid pair, after which hK1 cleaves kallistatin (human kallikrein-binding protein), a specific serpin for this protease, as well as somatostatin 1-14.	phe-phe amino acid	140-158	keratin 1	Homo sapiens	106-109
10191281-1	1999	We have explored in detail the determinants of specificity for the hydrolysis by human tissue kallikrein (hK1) of substrates containing the Phe-Phe amino acid pair, after which hK1 cleaves kallistatin (human kallikrein-binding protein), a specific serpin for this protease, as well as somatostatin 1-14.	phe-phe amino acid	140-158	keratin 1	Homo sapiens	177-180
10708807-2	2000	This study was performed to assess the possible apoptosis inhibitory effect of the immunomodulatory compound tri-(2-thioureido-S-ethyl)-amine (K-1) in U-937 and HL-60 leukaemia cell lines as model systems.	tri-(2-thioureidoethyl)amine	109-141	keratin 1	Homo sapiens	143-146
10708807-3	2000	Treatment of U-937 and HL-60 cells with K-1 inhibited etoposide (ETO)-induced apoptosis in both cell lines in a dose-dependent manner, IC(50)=200 microg/ml.	Etoposide	54-63	keratin 1	Homo sapiens	40-43
10708807-3	2000	Treatment of U-937 and HL-60 cells with K-1 inhibited etoposide (ETO)-induced apoptosis in both cell lines in a dose-dependent manner, IC(50)=200 microg/ml.	Etoposide	65-68	keratin 1	Homo sapiens	40-43
10708807-5	2000	Further, like other isothioureas, K-1 proved to be a potent inhibitor of nitric oxide synthase.	Thiourea	20-32	keratin 1	Homo sapiens	34-37
10708807-7	2000	These findings suggest that K-1 may serve as a potent inhibitor of apoptosis initiated by ETO or nitric oxide.	Etoposide	90-93	keratin 1	Homo sapiens	28-31
10597140-7	1999	Sequencing of the K1 gene in affected family members revealed a heterozygous A-to-T transversion at nucleotide 1435 within exon 7, converting isoleucine (ATT) to phenylalanine (TTT), (I479F).	Phenylalanine	162-175	keratin 1	Homo sapiens	18-20
10416619-4	1999	Similarly, cytokeratin 1 mRNA level was more suppressed in ATRA-treated LNSbeta clones than it was in LNSX cells.	Tretinoin	59-63	keratin 1	Homo sapiens	11-24
29711879-3	1999	The six fluorine atoms of K+  1 are coordinated to K+ in a distorted octahedral fashion.	Fluorine	8-16	keratin 1	Homo sapiens	26-31
10232403-0	1999	An asparagine to threonine substitution in the 1A domain of keratin 1: a novel mutation that causes epidermolytic hyperkeratosis.	Threonine	17-26	keratin 1	Homo sapiens	60-69
9737352-8	1998	Both vitamins K1 and K2 increased by 97.6% and 666.9%, respectively, in the MK-4 group.	menatetrenone	76-80	keratin 1	Homo sapiens	14-23
10084317-0	1999	A novel glutamic acid to aspartic acid mutation near the end of the 2B rod domain in the keratin 1 chain in epidermolytic hyperkeratosis.	Glutamic Acid	8-21	keratin 1	Homo sapiens	89-98
10084317-0	1999	A novel glutamic acid to aspartic acid mutation near the end of the 2B rod domain in the keratin 1 chain in epidermolytic hyperkeratosis.	Aspartic Acid	25-38	keratin 1	Homo sapiens	89-98
10084317-1	1999	We report a mutation in a mild case of epidermolytic hyperkeratosis that results in a glutamic acid to aspartic acid substitution in a novel location, codon 477 or position 106 of the 2B rod domain of the keratin 1 chain.	Glutamic Acid	86-99	keratin 1	Homo sapiens	205-214
10084317-1	1999	We report a mutation in a mild case of epidermolytic hyperkeratosis that results in a glutamic acid to aspartic acid substitution in a novel location, codon 477 or position 106 of the 2B rod domain of the keratin 1 chain.	Aspartic Acid	103-116	keratin 1	Homo sapiens	205-214
9833037-8	1998	The same arginine position has been mutated in the keratin 10 gene in epidermolytic hyperkeratosis, the keratin 14 gene in epidermolysis bullosa simplex, and the keratin 9 gene in hereditary EPPK in Western patients.	Arginine	9-17	keratin 1	Homo sapiens	191-195
9520414-2	1998	A 54-kDa protein was isolated by a biotin-high molecular mass kininogen (HK) affinity column that, on aminoterminal sequencing of tryptic digests, was identified as cytokeratin 1.	Biotin	35-41	keratin 1	Homo sapiens	165-178
9831504-2	1998	The troublesome assignments were for the K-1 = 0 lines of the o2 state of CH2DOH and the e2 state of CHD2OH, where a resonance is found for the J0J levels.	ch2doh	74-80	keratin 1	Homo sapiens	41-44
9540975-5	1998	Sodium dodecyl sulfate caused upregulation of involucrin and downregulation of cytokeratin 1 expression, which is associated with the hyperproliferative/inflammatory epidermal phenotype found in psoriasis, wound healing, and skin irritation.	Sodium Dodecyl Sulfate	0-22	keratin 1	Homo sapiens	79-92
9525283-4	1998	Both TCDD and EGF substantially reduced expression of the differentiation markers keratin 1 and keratin 10 in the normal and immortalized cells, and did so in an additive fashion.	Polychlorinated Dibenzodioxins	5-9	keratin 1	Homo sapiens	82-91
9484953-6	1998	Small, but significant differences in the individual binding parameters, K1 and K2, are found in the vincristine data.	Vincristine	101-112	keratin 1	Homo sapiens	73-82
9684913-1	1998	An association between schizophrenia and a rare perfect ten-repeat allele, K1p, of a tetranucleotide microsatellite polymorphism in the tyrosine hydroxylase gene has recently been reported.	tetranucleotide	85-100	keratin 1	Homo sapiens	75-78
9530108-2	1998	The initial rate of 32PO4 influx had saturation kinetics for external Na and PO4 with K1/2Na of 128 mM (PO4 = 0.1 mM) and K1/2PO4 of 0.084 mM (extracellular Na = 143 mM) in sham- and NaPi-3-transfected cells expressing the transporter.	32po4	20-25	keratin 1	Homo sapiens	122-129
9530108-2	1998	The initial rate of 32PO4 influx had saturation kinetics for external Na and PO4 with K1/2Na of 128 mM (PO4 = 0.1 mM) and K1/2PO4 of 0.084 mM (extracellular Na = 143 mM) in sham- and NaPi-3-transfected cells expressing the transporter.	po4	22-25	keratin 1	Homo sapiens	122-129
9530108-2	1998	The initial rate of 32PO4 influx had saturation kinetics for external Na and PO4 with K1/2Na of 128 mM (PO4 = 0.1 mM) and K1/2PO4 of 0.084 mM (extracellular Na = 143 mM) in sham- and NaPi-3-transfected cells expressing the transporter.	po4	77-80	keratin 1	Homo sapiens	122-129
9266709-3	1997	Replacement of the P2" residue Pro by Val in Abz-TSVIRRPQ-EDDnp gave a far less specific substrate that was rapidly hydrolysed by all five rat kallikreins and human kallikrein hK1.	Proline	31-34	keratin 1	Homo sapiens	176-179
9344799-0	1997	The Microwave Spectrum of the Methanol Dimer for K = 0 and 1 States The rotational spectrum of (CH3OH)2 has been observed in the 8 to 24 GHz region with a pulsed-beam Fabry-Perot cavity Fourier-transform microwave spectrometer.	Methanol	30-38	keratin 1	Homo sapiens	49-60
32223123-1	1997	Absolute rate constants have been measured for the gas-phase reactions of hydroxyl radicals with a series of methyl esters: methyl propionate (k 1), methyl butyrate (k 2), methyl valerate (k 3), and methyl caproate (k 4).	Hydroxyl Radical	74-91	keratin 1	Homo sapiens	143-146
32223123-1	1997	Absolute rate constants have been measured for the gas-phase reactions of hydroxyl radicals with a series of methyl esters: methyl propionate (k 1), methyl butyrate (k 2), methyl valerate (k 3), and methyl caproate (k 4).	methyl esters	109-122	keratin 1	Homo sapiens	143-146
9266709-3	1997	Replacement of the P2" residue Pro by Val in Abz-TSVIRRPQ-EDDnp gave a far less specific substrate that was rapidly hydrolysed by all five rat kallikreins and human kallikrein hK1.	Valine	38-41	keratin 1	Homo sapiens	176-179
9266709-3	1997	Replacement of the P2" residue Pro by Val in Abz-TSVIRRPQ-EDDnp gave a far less specific substrate that was rapidly hydrolysed by all five rat kallikreins and human kallikrein hK1.	abz-tsvirrpq-eddnp	45-63	keratin 1	Homo sapiens	176-179
9266709-7	1997	Competition experiments with Abz-TSVIRRPQ-EDDnp, which is resistant to most kallikreins, and Abz-TSVIRRVQ-EDDnp, a general kallikrein substrate, demonstrated that the former competitively inhibited hydrolysis by rK9 and hK1, with Ki values similar to the Km values for the substrate.	abz-tsvirrpq-eddnp	29-47	keratin 1	Homo sapiens	220-223
9219563-2	1997	Growth of these cells in 10 microM arsenate permitted the cultures to reach confluence, but prevented expression of 6 markers of suprabasal differentiation (involucrin, loricrin, filaggrin, spr 1, keratin 1 and keratin 10) as assayed by Northern blotting.	arsenic acid	35-43	keratin 1	Homo sapiens	197-206
9094252-7	1997	However, amiloride had a significant lower affinity in CF tissue (half-maximal blocker concentration, K1/2 = 586 +/- 59 nM) compared with non-CF tissue (K1/2 = 294 +/- 22 nM).	Amiloride	9-18	keratin 1	Homo sapiens	102-112
9094252-8	1997	Astonishingly, phenamil, a blocker which irreversibly blocks all epithelial Na+ channels hitherto described, inhibited the Na+ conductances of human nasal epithelium in a completely reversible way, but nevertheless with high affinity (non-CF: K1/2 = 12.5 +/- 1.2 nM; CF: K1/2 = 17.1 +/- 1.1 nM).	phenylamil	15-23	keratin 1	Homo sapiens	271-282
9060890-9	1997	Flow was defined by K1; volume of distribution (VD = K1/k2) of N-13 ammonia was used as an indirect indication of metabolic retention.	AMMONIA N-13	63-75	keratin 1	Homo sapiens	53-58
9054588-3	1997	To our knowledge it has not yet been demonstrated that the natural quinones, vitamin K1 and K2, exert the same activity.	Quinones	67-75	keratin 1	Homo sapiens	85-94
8943260-4	1996	ATP-inhibited K+ flux was completely reactivated by both GTP (K1/2 = 7 microM) and GDP (K1/2 = 140 microM).	Adenosine Triphosphate	0-3	keratin 1	Homo sapiens	62-86
8943260-4	1996	ATP-inhibited K+ flux was completely reactivated by both GTP (K1/2 = 7 microM) and GDP (K1/2 = 140 microM).	Guanosine Triphosphate	57-60	keratin 1	Homo sapiens	62-86
8921299-2	1996	Cyclic nucleotide-gated channels on olfactory receptor neurons showed selective channel activation by cAMP (K1/2 = 5 microM) and cGMP (K1/2 = 2 microM), a unitary conductance of approximately 20 pS, a reversal potential of single-channel currents close to 0 mV, a linear current-voltage relationship over the range of -80 to 80 mV and a strong extracellular but a weaker intracellular blocking effect of Ca2+.	Nucleotides, Cyclic	0-17	keratin 1	Homo sapiens	108-133
8921299-2	1996	Cyclic nucleotide-gated channels on olfactory receptor neurons showed selective channel activation by cAMP (K1/2 = 5 microM) and cGMP (K1/2 = 2 microM), a unitary conductance of approximately 20 pS, a reversal potential of single-channel currents close to 0 mV, a linear current-voltage relationship over the range of -80 to 80 mV and a strong extracellular but a weaker intracellular blocking effect of Ca2+.	Cyclic AMP	102-106	keratin 1	Homo sapiens	108-133
8935794-4	1996	In each case the entropy of activation was positive (14.1 cal K-1 mol-1 for PY and 56.4 cal K-1 mol-1 for MC).	methyl cellosolve	106-108	keratin 1	Homo sapiens	92-95
8917340-6	1996	Three tryptic peptides of the 35 kD band were sequenced, identifying it as a fragment of cytokeratin 1, a structural protein not normally expressed in the thyroid.	Peptides	14-22	keratin 1	Homo sapiens	89-102
8763798-3	1996	We report that 8-Br-cGMP strongly down-regulates the odour sensitivity of the cells, with a K1/2 of 460 nM.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	15-24	keratin 1	Homo sapiens	92-106
8794756-11	1996	The Ca(2+)-binding constant (K1/2 = 5.33 pCa units) was within the range reported for the low-affinity sites of mammalian cTnC.	ctnc	122-126	keratin 1	Homo sapiens	29-37
8804600-4	1996	In this study, we have used circular dichroism (CD) spectroscopy to examine the binding mechanism and the binding constants (K1 and K2) of cations to gramicidin in the double helical form in methanol solution.	Methanol	191-199	keratin 1	Homo sapiens	125-134
8557941-0	1996	Food sources and dietary intakes of vitamin K-1 (phylloquinone) in the American diet: data from the FDA Total Diet Study.	Vitamin K 1	49-62	keratin 1	Homo sapiens	44-47
8557941-1	1996	OBJECTIVE: To identify important food sources and estimate dietary intake of vitamin K-1 (phylloquinone) in the American diet.	Vitamin K 1	90-103	keratin 1	Homo sapiens	85-88
9159190-6	1996	This 103 bp fragment contains sequences of an AP-1 site (TGAGTCA), a SP-1 site (GGGCGG), and shares homology with two elements in the human keratin-1 promoter, within the regions identified as mediating the calcium responsiveness of that gene in keratinocytes.	Calcium	207-214	keratin 1	Homo sapiens	140-149
11666997-4	1996	The reaction of the title diketone (3) with phenyl Grignard produces (with rate constant k(1)) the conjugate base (6-M) of 10-hydroxy-10-phenylcyclooctadecanone (6), which is subsequently converted (with rate constant k(2)) to the conjugate base of the title diol, as a mixture of the cis (7, 55%) and trans (8, 45%) isomers.	1,4-diselenophene-1,4-diketone	26-34	keratin 1	Homo sapiens	89-93
11666997-4	1996	The reaction of the title diketone (3) with phenyl Grignard produces (with rate constant k(1)) the conjugate base (6-M) of 10-hydroxy-10-phenylcyclooctadecanone (6), which is subsequently converted (with rate constant k(2)) to the conjugate base of the title diol, as a mixture of the cis (7, 55%) and trans (8, 45%) isomers.	10-hydroxy-10-phenylcyclooctadecanone	123-160	keratin 1	Homo sapiens	89-93
11666997-4	1996	The reaction of the title diketone (3) with phenyl Grignard produces (with rate constant k(1)) the conjugate base (6-M) of 10-hydroxy-10-phenylcyclooctadecanone (6), which is subsequently converted (with rate constant k(2)) to the conjugate base of the title diol, as a mixture of the cis (7, 55%) and trans (8, 45%) isomers.	diol	259-263	keratin 1	Homo sapiens	89-93
7532198-5	1995	This arginine residue in a highly conserved region of keratins 1 and 10 is affected by disruptive missense point mutations in many patients with bullous ichthyosiform erythroderma.	Arginine	5-13	keratin 1	Homo sapiens	54-71
8599674-3	1995	Measurements by differential scanning calorimetry have shown that this vitreous but freezable water fraction undergoes, on reheating at a rate of 30 K min-1, a glass-->liquid transition with an onset temperature of between approximately 164 and approximately 174 K, with a width of between approximately 9 and approximately 16 degrees and an increase in heat capacity of between approximately 20 and approximately 40 J K-1 (mol of freezable water)-1 but that the glass transition disappears upon crystallization of the freezable water.	Water	94-99	keratin 1	Homo sapiens	422-425
7548087-5	1995	A set of kinetic constants for 20 degrees C 50 mM NaCl is K1 = 2 x 10(4) M-1, k2 = 200 s-1, k3 = 9 s-1, k5 = 0.01 s-1, and K6 = 2 x 10(-5) M. Values of K1 and K6 are estimates for mant-ATP and mant-ADP, respectively.	Sodium Chloride	50-54	keratin 1	Homo sapiens	152-161
7548087-5	1995	A set of kinetic constants for 20 degrees C 50 mM NaCl is K1 = 2 x 10(4) M-1, k2 = 200 s-1, k3 = 9 s-1, k5 = 0.01 s-1, and K6 = 2 x 10(-5) M. Values of K1 and K6 are estimates for mant-ATP and mant-ADP, respectively.	Mant-ATP	180-188	keratin 1	Homo sapiens	152-161
7548087-5	1995	A set of kinetic constants for 20 degrees C 50 mM NaCl is K1 = 2 x 10(4) M-1, k2 = 200 s-1, k3 = 9 s-1, k5 = 0.01 s-1, and K6 = 2 x 10(-5) M. Values of K1 and K6 are estimates for mant-ATP and mant-ADP, respectively.	3'-O-(N-methylanthraniloyl)adenosine 5'-diphosphate	193-201	keratin 1	Homo sapiens	152-161
7873526-4	1995	10-Fluorofarnesyl diphosphate (15) was the most effective competitive inhibitor, with a K1 of 16 nM compared to the Km for 1 of 87 nM, while the ether analog of farnesyl diphosphate, 8, an extremely potent inhibitor of squalene synthase, showed only modest inhibition of trichodiene synthase, with a K1/Km of 70.	10-fluorofarnesyl diphosphate	0-29	keratin 1	Homo sapiens	300-311
7873526-4	1995	10-Fluorofarnesyl diphosphate (15) was the most effective competitive inhibitor, with a K1 of 16 nM compared to the Km for 1 of 87 nM, while the ether analog of farnesyl diphosphate, 8, an extremely potent inhibitor of squalene synthase, showed only modest inhibition of trichodiene synthase, with a K1/Km of 70.	Diphosphates	18-29	keratin 1	Homo sapiens	300-311
7530273-8	1995	Subconfluent cells cultured in medium containing high calcium and no exogenous growth factor induced expression of K1 and K10 transcripts, but commitment and loss of proliferative potential were not observed.	Calcium	54-61	keratin 1	Homo sapiens	115-117
7530273-10	1995	However, suprabasal K1 and K10 gene expression also was regulated by medium calcium and exogenous growth-factor concentrations in subconfluent cultures that promoted cell-cell association.	Calcium	76-83	keratin 1	Homo sapiens	20-22
7535512-8	1994	Bidimensional gel electrophoresis showed that cytokeratins 1, 2, 10 and 11 disappeared only in the tretinoin group (60 p. 100 of the cases).	Tretinoin	99-108	keratin 1	Homo sapiens	46-74
8542022-10	1995	The K1/K2 polymorphism is due to a C to T substitution in exon 6, encoding a threonine to methionine change.	Threonine	77-86	keratin 1	Homo sapiens	4-9
8542022-10	1995	The K1/K2 polymorphism is due to a C to T substitution in exon 6, encoding a threonine to methionine change.	Methionine	90-100	keratin 1	Homo sapiens	4-9
7721724-2	1994	The affinity of the membrane-bound enzyme for ATP during NADH oxidation was calculated from the ratio of the rate constants for the forward binding step (k+1) and the reverse dissociation step (k-1).	Adenosine Triphosphate	46-49	keratin 1	Homo sapiens	194-197
7721724-2	1994	The affinity of the membrane-bound enzyme for ATP during NADH oxidation was calculated from the ratio of the rate constants for the forward binding step (k+1) and the reverse dissociation step (k-1).	NAD	57-61	keratin 1	Homo sapiens	194-197
7721724-4	1994	In the presence of NADH and ADP an additional enhancement of k-1 was observed.	NAD	19-23	keratin 1	Homo sapiens	61-64
7721724-4	1994	In the presence of NADH and ADP an additional enhancement of k-1 was observed.	Adenosine Diphosphate	28-31	keratin 1	Homo sapiens	61-64
8061228-4	1994	For both the Zn(II)-HSA and Zn(II)-BSA systems, the successive stability constants are basically similar, though such constants for the latter generally slightly larger than those for the former; the order of magnitude of K1 and K2 was found to be approximately 10(5) M-1.	zn(ii)-hsa	13-23	keratin 1	Homo sapiens	222-231
8061228-4	1994	For both the Zn(II)-HSA and Zn(II)-BSA systems, the successive stability constants are basically similar, though such constants for the latter generally slightly larger than those for the former; the order of magnitude of K1 and K2 was found to be approximately 10(5) M-1.	Zinc	13-19	keratin 1	Homo sapiens	222-231
8061228-8	1994	Such a self-association mechanism and the order of magnitude of K1 and K2 both to some extent support the inference that the zinc group ions are bound to the cysteinyl sulphur atoms.	cysteinyl sulphur	158-175	keratin 1	Homo sapiens	64-73
7721724-3	1994	k-1 was accelerated several orders of magnitude by NADH oxidation.	NAD	51-55	keratin 1	Homo sapiens	0-3
7528239-5	1994	Sequence analysis identified a single base change in the amino-terminal V1 variable subdomain of keratin 1, which caused a lysine to isoleucine substitution.	Lysine	123-129	keratin 1	Homo sapiens	97-106
7528239-5	1994	Sequence analysis identified a single base change in the amino-terminal V1 variable subdomain of keratin 1, which caused a lysine to isoleucine substitution.	Isoleucine	133-143	keratin 1	Homo sapiens	97-106
7510286-0	1994	Differentiation-specific expression of human keratin 1 is mediated by a composite AP-1/steroid hormone element.	Steroids	87-102	keratin 1	Homo sapiens	45-54
7535512-11	1994	Bidimensional electrophoresis demonstrated that cytokeratins 1, 2, 10 and 11 disappeared in 43 p. 100 of the patients treated with tretinoin.	Tretinoin	131-140	keratin 1	Homo sapiens	48-76
8239497-8	1993	In spite of this different reactivity with Mabs, analysis by proton nuclear magnetic resonance (1H NMR) proved that carbohydrate structure of K-1 and H-2 were the same: NeuAc alpha 2-->3Ga1 beta 1-->4 [Fuc alpha 1-->3] G1cNAc beta 1-->3 Ga1 beta 1-->4G1c beta 1-->1Cer.	Hydrogen	96-98	keratin 1	Homo sapiens	142-153
8187245-5	1994	Somewhat unexpectedly, the negative groups of the kringle correspond to an enlarged anionic center of the lysine binding site of lysine binding kringles such as plasminogen K1 and K4 and TPA K2.	Lysine	106-112	keratin 1	Homo sapiens	173-193
8187245-5	1994	Somewhat unexpectedly, the negative groups of the kringle correspond to an enlarged anionic center of the lysine binding site of lysine binding kringles such as plasminogen K1 and K4 and TPA K2.	Lysine	129-135	keratin 1	Homo sapiens	173-193
8239497-8	1993	In spite of this different reactivity with Mabs, analysis by proton nuclear magnetic resonance (1H NMR) proved that carbohydrate structure of K-1 and H-2 were the same: NeuAc alpha 2-->3Ga1 beta 1-->4 [Fuc alpha 1-->3] G1cNAc beta 1-->3 Ga1 beta 1-->4G1c beta 1-->1Cer.	Carbohydrates	116-128	keratin 1	Homo sapiens	142-153
8239497-8	1993	In spite of this different reactivity with Mabs, analysis by proton nuclear magnetic resonance (1H NMR) proved that carbohydrate structure of K-1 and H-2 were the same: NeuAc alpha 2-->3Ga1 beta 1-->4 [Fuc alpha 1-->3] G1cNAc beta 1-->3 Ga1 beta 1-->4G1c beta 1-->1Cer.	N-Acetylneuraminic Acid	169-174	keratin 1	Homo sapiens	142-153
7688203-7	1993	Suramin and reactive blue 2, which are recognized antagonists of ATP-operated purinergic receptors in other tissues, inhibited ATP-induced uptake of ethidium+ in lymphocytes with K1/2 of 61 and 69 microM, respectively.	Suramin	0-7	keratin 1	Homo sapiens	179-189
7688203-7	1993	Suramin and reactive blue 2, which are recognized antagonists of ATP-operated purinergic receptors in other tissues, inhibited ATP-induced uptake of ethidium+ in lymphocytes with K1/2 of 61 and 69 microM, respectively.	Cibacron Blue F 3GA	12-27	keratin 1	Homo sapiens	179-189
7688203-7	1993	Suramin and reactive blue 2, which are recognized antagonists of ATP-operated purinergic receptors in other tissues, inhibited ATP-induced uptake of ethidium+ in lymphocytes with K1/2 of 61 and 69 microM, respectively.	Ethidium	149-157	keratin 1	Homo sapiens	179-189
7688203-8	1993	However, hexamethylene amiloride was a more potent inhibitor of ATP-induced ethidium+ uptake with a K1/2 of 13 microM.	5-(N,N-hexamethylene)amiloride	9-32	keratin 1	Homo sapiens	100-110
7688203-8	1993	However, hexamethylene amiloride was a more potent inhibitor of ATP-induced ethidium+ uptake with a K1/2 of 13 microM.	Adenosine Triphosphate	64-67	keratin 1	Homo sapiens	100-110
7688203-8	1993	However, hexamethylene amiloride was a more potent inhibitor of ATP-induced ethidium+ uptake with a K1/2 of 13 microM.	Ethidium	76-84	keratin 1	Homo sapiens	100-110
8314753-5	1993	Comparisons of the high-field methyl and aromatic regions of the uPA/K and tPA/K2 spectra against those from the Pgn/K1 and K4 homologues afford the immediate assignment of signals stemming from conserved residues, such as the characteristic high-field shifted Leu46 delta, delta"-methyl doublets, and the aromatic side chains at the hydrophobic core, in particular those from Trp25, His48a, Tyr50, and Trp62.	his48a	384-390	keratin 1	Homo sapiens	117-126
1281859-0	1992	The two size alleles of human keratin 1 are due to a deletion in the glycine-rich carboxyl-terminal V2 subdomain.	Glycine	69-76	keratin 1	Homo sapiens	30-39
8391018-3	1993	An additional inhibition study (pretreatment with 0.15 mg/kg of flumazenil) was performed on one of the volunteers, which resulted in an average gray matter K1/k2 estimate of 0.68 +/- 0.08 ml/ml (linear three-compartment model, nine brain regions).	Flumazenil	64-74	keratin 1	Homo sapiens	157-162
8499471-2	1993	We now report that the anion-exchange inhibitor DIDS (4,4"-diisothiocyanostilbene-2,2"-disulfonic acid) inhibited 55-60% of the deformation-induced flux with an apparent K1/2 of 1 microM.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	48-52	keratin 1	Homo sapiens	170-179
8499471-2	1993	We now report that the anion-exchange inhibitor DIDS (4,4"-diisothiocyanostilbene-2,2"-disulfonic acid) inhibited 55-60% of the deformation-induced flux with an apparent K1/2 of 1 microM.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	54-102	keratin 1	Homo sapiens	170-179
8145146-7	1993	Analysis of the dose-response relations for OA and MC on ventricular cell ICa were best fitted with a single-site relationship with a K1/2 of 1.58 microM and 0.81 microM, respectively.	microcystin	51-53	keratin 1	Homo sapiens	134-143
7679103-2	1993	In this study, small assembly-competent oligomers of mouse and human keratin 1/keratin 10 keratin filaments were cross-linked by the formation of disulfide bonds catalyzed by the copper-phenanthroline reaction.	Disulfides	146-155	keratin 1	Homo sapiens	69-97
7679103-2	1993	In this study, small assembly-competent oligomers of mouse and human keratin 1/keratin 10 keratin filaments were cross-linked by the formation of disulfide bonds catalyzed by the copper-phenanthroline reaction.	Copper	179-185	keratin 1	Homo sapiens	69-97
7679103-2	1993	In this study, small assembly-competent oligomers of mouse and human keratin 1/keratin 10 keratin filaments were cross-linked by the formation of disulfide bonds catalyzed by the copper-phenanthroline reaction.	Phenanthrolines	186-200	keratin 1	Homo sapiens	69-97
7687781-5	1993	In post-confluent cultures, retinoic acid prevented the appearance of keratin 1, which accompanied the development of a squamous phenotype by cells maintained under these conditions.	Tretinoin	28-41	keratin 1	Homo sapiens	70-79
1531965-1	1992	Inhibition of ATPase activity by vanadate, having K1/2 of 0.5 mM, was demonstrated in the CF1-ATPase.	Vanadates	33-41	keratin 1	Homo sapiens	50-59
1381288-3	1992	We have now identified a leucine----proline amino acid substitution in the conserved H1 subdomain of keratin 1 that is present only in affected family members.	Leucine	25-32	keratin 1	Homo sapiens	101-110
1573142-0	1992	Development of a diet low in vitamin K-1 (phylloquinone).	Vitamin K 1	42-55	keratin 1	Homo sapiens	37-40
1314673-5	1992	In the absence of ADP and phosphate four rate constants are relevant: k1 and k-1, the on and off rate constants for ATP binding; k2, the transphosphorylation rate constant and k3, the constant that governs the dephosphorylation rate.	Phosphates	26-35	keratin 1	Homo sapiens	70-80
1314673-5	1992	In the absence of ADP and phosphate four rate constants are relevant: k1 and k-1, the on and off rate constants for ATP binding; k2, the transphosphorylation rate constant and k3, the constant that governs the dephosphorylation rate.	Adenosine Triphosphate	116-119	keratin 1	Homo sapiens	70-80
1370600-9	1992	ATP-induced 86Rb efflux showed a sigmoid dependence on the concentration of ATP and Hill analysis gave K1/2 of 90 and 130 microM and n values of 2.5 and 2.5 for KCl and NaCl media, respectively.	Adenosine Triphosphate	0-3	keratin 1	Homo sapiens	103-113
1370600-9	1992	ATP-induced 86Rb efflux showed a sigmoid dependence on the concentration of ATP and Hill analysis gave K1/2 of 90 and 130 microM and n values of 2.5 and 2.5 for KCl and NaCl media, respectively.	Rubidium-86	12-16	keratin 1	Homo sapiens	103-113
1370600-9	1992	ATP-induced 86Rb efflux showed a sigmoid dependence on the concentration of ATP and Hill analysis gave K1/2 of 90 and 130 microM and n values of 2.5 and 2.5 for KCl and NaCl media, respectively.	Adenosine Triphosphate	76-79	keratin 1	Homo sapiens	103-113
1725165-2	1991	Retinoic acid (RA) is known to modulate stratified squamous epithelial differentiation, including expression of the basal cell keratin K19 and the suprabasal keratins K1/K10 and K4/K13.	Tretinoin	0-13	keratin 1	Homo sapiens	167-173
1725165-2	1991	Retinoic acid (RA) is known to modulate stratified squamous epithelial differentiation, including expression of the basal cell keratin K19 and the suprabasal keratins K1/K10 and K4/K13.	Tretinoin	15-17	keratin 1	Homo sapiens	167-173
1654222-4	1991	Among them, vitamins K1 and K2 inhibited the lipid peroxidation, as did UQ-10, with the order of effectiveness: UQ-10 greater than K2 greater than K1.	uq-10	72-77	keratin 1	Homo sapiens	21-30
1654222-4	1991	Among them, vitamins K1 and K2 inhibited the lipid peroxidation, as did UQ-10, with the order of effectiveness: UQ-10 greater than K2 greater than K1.	uq-10	112-117	keratin 1	Homo sapiens	21-30
34890750-3	2022	Keratin 1 (K1) is a type II keratin whose structure is comprised of a coiled-coil central domain flanked by flexible, glycine-rich loops in the N- and C-termini.	Glycine	118-125	keratin 1	Homo sapiens	0-9
1845966-1	1991	The reactions of pyrene-labeled actin with myosin subfragment 1 (S1) and S1-ligand complexes at low ionic strength are described by the schemes [formula: see text] where M refers to a myosin head; A is actin; L is ligand; the asterisk refers to a high fluorescence state of actin; and K1 and K3 are association constants.	pyrene	17-23	keratin 1	Homo sapiens	285-294
1701189-6	1990	Western blots of cyanogen bromide digests of the K1 keratin showed that both Kab antibodies reacted with a 30-kD fragment of the molecule presumed to be the N-terminal CNBr peptide.	Cyanogen Bromide	17-33	keratin 1	Homo sapiens	49-59
1706998-5	1990	Extracts from both compartments showed on two-dimensional (2D)-polyacrylamide gels a group of presumptive K1 and K10-turnover products in a wide pI (basic to acidic) and Mr range (56,000-65,000), named IC-I to III and IC-IV, respectively.	polyacrylamide	63-77	keratin 1	Homo sapiens	106-116
2317551-6	1990	Above the fluid-gel transition temperature, Tc, the diffusion rate (f) of the monopyrenyl probe (pyn PC) is accordingly related to K by: pE approximately K/(K + 1/2f + tau -1M), where pE is the probability of excimer formation between nearest neighbor pyn PC probes, and tau M is the monomer lifetime.	Technetium	44-46	keratin 1	Homo sapiens	154-175
34626506-5	2022	D-LCERDP-10.0 (10.0 wt% DP) synchronously possesses excellent intrinsic thermal conductivity and intrinsic flame retardancy, with thermal conductivity coefficient in vertical and parallel direction (lambda  and lambda  ) of 0.34 W m-1 K-1 and 1.30 W m-1 K-1 , much higher than that of general bisphenol A epoxy resin (E-51, lambda  of 0.19 W m-1 K-1 , lambda  of 0.65 W m-1 K-1 ).	d-lcerdp	0-8	keratin 1	Homo sapiens	235-257
1966957-3	1990	Incorporation of these assumptions into the fluoro-deoxyglucose method in humans allowed us to replace the brain blood transfer (k2*) and phosphorylation (k3*) coefficients by the coefficients of net (K*) and undirectional (K1*) transfer in the operational equation of the method, and to calculate the lumped constant directly.	Fluorodeoxyglucose F18	44-63	keratin 1	Homo sapiens	224-227
34391753-9	2021	Overall, our results offered preclinical proof for the use of P18-PEtOx-DOPE-DOX nanoliposomes in KRT-1+ breast cancer therapy.	Doxorubicin	77-80	keratin 1	Homo sapiens	98-103
34645125-4	2021	Methods: Half maximal inhibitory concentration (IC50) values of LGZ in BRAF-mutated PTC cell lines (BCPAP and K1) were determined using MTT assay.	monooxyethylene trimethylolpropane tristearate	136-139	keratin 1	Homo sapiens	100-112
34645125-9	2021	Results: Treatment with LGZ or RGZ significantly inhibited transforming growth factor-beta1 (TGF-beta1)-induced EMT-associated processes such as fibroblast-like morphological changes, EMT-related protein expression, and increased cell migration and invasion in BCPAP and K1 cells.	lobeglitazone	24-27	keratin 1	Homo sapiens	261-273
34645125-9	2021	Results: Treatment with LGZ or RGZ significantly inhibited transforming growth factor-beta1 (TGF-beta1)-induced EMT-associated processes such as fibroblast-like morphological changes, EMT-related protein expression, and increased cell migration and invasion in BCPAP and K1 cells.	Rosiglitazone	31-34	keratin 1	Homo sapiens	261-273
35484158-2	2022	Here, we report a giant barocaloric effect in inorganic NH4I with reversible entropy changes of (Formula: see text) ~71 J K-1 kg-1 around room temperature, associated with a structural phase transition.	barocaloric	24-35	keratin 1	Homo sapiens	122-130
34155226-3	2021	Here we discovered that the quadruple perovskite structure ferrimagnet BiCu3Cr4O12 shows large multiple caloric effects at the first-order charge transition occurring around 190 K. Large latent heat and the corresponding isothermal entropy change, 28.2 J K-1 kg-1, can be utilized by applying both magnetic fields (a magnetocaloric effect) and pressure (a barocaloric effect).	perovskite	38-48	keratin 1	Homo sapiens	255-263
34155226-3	2021	Here we discovered that the quadruple perovskite structure ferrimagnet BiCu3Cr4O12 shows large multiple caloric effects at the first-order charge transition occurring around 190 K. Large latent heat and the corresponding isothermal entropy change, 28.2 J K-1 kg-1, can be utilized by applying both magnetic fields (a magnetocaloric effect) and pressure (a barocaloric effect).	bicu3cr4o12	71-82	keratin 1	Homo sapiens	255-263
35565883-1	2022	The aim of the study was to estimate the content of K1, K2 (MK-n) as well as total K vitamins and their sources in the diets of 1985 PURE Poland study participants based on the FFQ questionnaire.	mk-n	60-64	keratin 1	Homo sapiens	52-58
34993998-6	2022	Combination of Vitamin K analogues such as Vitamin K1, Vitamin K2, Vitamin K3 and Vitamin K5 with other chemotherapeutic drugs have demonstrated a safe, cost effective and most efficient way to overcome drug resistance and improve the outcomes of prevailing chemotherapy.	Vitamin K	15-24	keratin 1	Homo sapiens	51-65
35444364-4	2022	This MOF compound exhibits colossal thermal changes of DeltaS ~ 311 J K-1 kg-1 and DeltaH ~ 93 kJ kg-1 at room temperature (298 K) and under only 16 bar, pressure which is similar to that of common gas refrigerants at the same operating temperature (for instance, p(CO2) ~ 64 bar and p(R134a) ~ 6 bar) and noticeably lower than p > 1000 bar of most solid barocaloric materials.	MOF protocol	5-8	keratin 1	Homo sapiens	70-78
35363433-4	2022	The indicators reflecting arsenic-induced skin lesions (Krt1 and Krt10) were also significantly elevated, which contributed to the occurrence of skin lesions.	Arsenic	26-33	keratin 1	Homo sapiens	56-60
35363433-6	2022	In the arsenic-exposed group, the upregulation of METTL3 exacerbated the increase in cytokine levels (IL-6, IL-17, and IL-10), which was associated with the upregulation of keratins (Krt1 and Krt10).	Arsenic	7-14	keratin 1	Homo sapiens	183-187
2458346-5	1988	The degrees and specific activities (that is, turnover rates) of phosphorylation of these sites varied widely between different isoelectric variants (phosphate isomers) of keratin 1 chains and correlated with their locations on the chain: those sites on the more exposed E1 and E2 subdomains were fully phosphorylated and turning over at high rates, while a site near the end of the rod domain in a presumably more confined location was only slightly phosphorylated and turning over at low rate.	Phosphates	150-159	keratin 1	Homo sapiens	172-181
2591045-5	1989	Sensitivity (detection limit) of the assay was 30 pg for vitamin K1 and 5 ng for vitamin E per injection.	Vitamin E	81-90	keratin 1	Homo sapiens	65-73
2551068-3	1989	The addition of the fragments of plasminogen such as kringle 1 to 3 (K1-3), and K4 resulted in the facilitation of the conversion of sct-PA to tct-PA by plasmin.	Protactinium	136-139	keratin 1	Homo sapiens	69-73
2551068-3	1989	The addition of the fragments of plasminogen such as kringle 1 to 3 (K1-3), and K4 resulted in the facilitation of the conversion of sct-PA to tct-PA by plasmin.	tct-pa	143-149	keratin 1	Homo sapiens	69-73
2548104-5	1989	In keeping with expectations, the apparent entropy change for nipecotic acid binding (112 +/- 13 J.K-1) was more favorable than the apparent entropy change for gamma-aminobutyric acid binding (61.3 +/- 6.6 J.K-1).	nipecotic acid	62-76	keratin 1	Homo sapiens	99-102
2548104-5	1989	In keeping with expectations, the apparent entropy change for nipecotic acid binding (112 +/- 13 J.K-1) was more favorable than the apparent entropy change for gamma-aminobutyric acid binding (61.3 +/- 6.6 J.K-1).	nipecotic acid	62-76	keratin 1	Homo sapiens	208-211
2472990-5	1989	Moreover, in both HaCaT and HaCaT-ras clones the epidermal "suprabasal" keratins, K1 and K10, were expressed in conventional submerged cultures (at normal vitamin A levels), markedly rising with cell density, but not strictly correlated with the degree of stratification.	Vitamin A	155-164	keratin 1	Homo sapiens	82-92
2855257-5	1988	The estimations of the values K1 and K2 in water-alcohol mixtures and in aqueous micellar solutions of surfactant together with kinetical and spectral data show that the increase of K1 and K2 in reversed micelles is caused generally by redox potential changes of low-molecular reagents.	Water	43-48	keratin 1	Homo sapiens	30-39
2855257-5	1988	The estimations of the values K1 and K2 in water-alcohol mixtures and in aqueous micellar solutions of surfactant together with kinetical and spectral data show that the increase of K1 and K2 in reversed micelles is caused generally by redox potential changes of low-molecular reagents.	Water	43-48	keratin 1	Homo sapiens	182-191
2855257-5	1988	The estimations of the values K1 and K2 in water-alcohol mixtures and in aqueous micellar solutions of surfactant together with kinetical and spectral data show that the increase of K1 and K2 in reversed micelles is caused generally by redox potential changes of low-molecular reagents.	Alcohols	49-56	keratin 1	Homo sapiens	30-39
2855257-5	1988	The estimations of the values K1 and K2 in water-alcohol mixtures and in aqueous micellar solutions of surfactant together with kinetical and spectral data show that the increase of K1 and K2 in reversed micelles is caused generally by redox potential changes of low-molecular reagents.	Alcohols	49-56	keratin 1	Homo sapiens	182-191
2850082-2	1988	Single channel slope conductance averaged 26 ps; tetrodotoxin block of the channels was voltage dependent with a K1/2 at 0 mV of 51 nM.	Tetrodotoxin	49-61	keratin 1	Homo sapiens	113-122
24221516-3	1988	Formation of the pH gradient half-saturates at 0.3 mM MgATP, peaks at pH 7, and is competitively inhibited by ADP (k i<=0.1 mM), but not by Pi; it is hardly inhibited by orthovanadate, quickly dissipated by monensink 2=18 nM), nigericin (k 1/2=25 nM), and sluggishly by N-ethylmaleimide (k 1/2 35 muM).	Adenosine Diphosphate	110-113	keratin 1	Homo sapiens	241-244
3421956-3	1988	The second-order rate constants, k-1, obtained are 1.34 x 10(-1) M-1s-1 for 1, 2.42 x 10(-1) M-1s-1 for 2, and 3.65 x 10(-1) M-1s-1 for 3 at 25.0 degrees C. The result indicates that the rate constants increase as the total electron donating capacity of the alkyl substituents at alpha-carbon atom of hydroperoxides increases.	1s	67-69	keratin 1	Homo sapiens	33-36
3421956-3	1988	The second-order rate constants, k-1, obtained are 1.34 x 10(-1) M-1s-1 for 1, 2.42 x 10(-1) M-1s-1 for 2, and 3.65 x 10(-1) M-1s-1 for 3 at 25.0 degrees C. The result indicates that the rate constants increase as the total electron donating capacity of the alkyl substituents at alpha-carbon atom of hydroperoxides increases.	1s	95-97	keratin 1	Homo sapiens	33-36
3421956-3	1988	The second-order rate constants, k-1, obtained are 1.34 x 10(-1) M-1s-1 for 1, 2.42 x 10(-1) M-1s-1 for 2, and 3.65 x 10(-1) M-1s-1 for 3 at 25.0 degrees C. The result indicates that the rate constants increase as the total electron donating capacity of the alkyl substituents at alpha-carbon atom of hydroperoxides increases.	1s	95-97	keratin 1	Homo sapiens	33-36
3421956-3	1988	The second-order rate constants, k-1, obtained are 1.34 x 10(-1) M-1s-1 for 1, 2.42 x 10(-1) M-1s-1 for 2, and 3.65 x 10(-1) M-1s-1 for 3 at 25.0 degrees C. The result indicates that the rate constants increase as the total electron donating capacity of the alkyl substituents at alpha-carbon atom of hydroperoxides increases.	Carbon	286-292	keratin 1	Homo sapiens	33-36
3421956-3	1988	The second-order rate constants, k-1, obtained are 1.34 x 10(-1) M-1s-1 for 1, 2.42 x 10(-1) M-1s-1 for 2, and 3.65 x 10(-1) M-1s-1 for 3 at 25.0 degrees C. The result indicates that the rate constants increase as the total electron donating capacity of the alkyl substituents at alpha-carbon atom of hydroperoxides increases.	Hydrogen Peroxide	301-315	keratin 1	Homo sapiens	33-36
3421956-4	1988	The above rates, k-1, are about seven order of magnitude lower than those, k1, for the reaction of vitamin E with peroxyl radical.	Vitamin E	99-108	keratin 1	Homo sapiens	17-20
3421956-4	1988	The above rates, k-1, are about seven order of magnitude lower than those, k1, for the reaction of vitamin E with peroxyl radical.	perhydroxyl radical	114-129	keratin 1	Homo sapiens	17-20
24221516-3	1988	Formation of the pH gradient half-saturates at 0.3 mM MgATP, peaks at pH 7, and is competitively inhibited by ADP (k i<=0.1 mM), but not by Pi; it is hardly inhibited by orthovanadate, quickly dissipated by monensink 2=18 nM), nigericin (k 1/2=25 nM), and sluggishly by N-ethylmaleimide (k 1/2 35 muM).	Adenosine Triphosphate	54-59	keratin 1	Homo sapiens	241-244
24221516-3	1988	Formation of the pH gradient half-saturates at 0.3 mM MgATP, peaks at pH 7, and is competitively inhibited by ADP (k i<=0.1 mM), but not by Pi; it is hardly inhibited by orthovanadate, quickly dissipated by monensink 2=18 nM), nigericin (k 1/2=25 nM), and sluggishly by N-ethylmaleimide (k 1/2 35 muM).	Adenosine Triphosphate	54-59	keratin 1	Homo sapiens	291-294
24221516-3	1988	Formation of the pH gradient half-saturates at 0.3 mM MgATP, peaks at pH 7, and is competitively inhibited by ADP (k i<=0.1 mM), but not by Pi; it is hardly inhibited by orthovanadate, quickly dissipated by monensink 2=18 nM), nigericin (k 1/2=25 nM), and sluggishly by N-ethylmaleimide (k 1/2 35 muM).	Adenosine Diphosphate	110-113	keratin 1	Homo sapiens	291-294
24221516-3	1988	Formation of the pH gradient half-saturates at 0.3 mM MgATP, peaks at pH 7, and is competitively inhibited by ADP (k i<=0.1 mM), but not by Pi; it is hardly inhibited by orthovanadate, quickly dissipated by monensink 2=18 nM), nigericin (k 1/2=25 nM), and sluggishly by N-ethylmaleimide (k 1/2 35 muM).	Vanadates	173-186	keratin 1	Homo sapiens	241-244
24221516-3	1988	Formation of the pH gradient half-saturates at 0.3 mM MgATP, peaks at pH 7, and is competitively inhibited by ADP (k i<=0.1 mM), but not by Pi; it is hardly inhibited by orthovanadate, quickly dissipated by monensink 2=18 nM), nigericin (k 1/2=25 nM), and sluggishly by N-ethylmaleimide (k 1/2 35 muM).	Vanadates	173-186	keratin 1	Homo sapiens	291-294
24221516-3	1988	Formation of the pH gradient half-saturates at 0.3 mM MgATP, peaks at pH 7, and is competitively inhibited by ADP (k i<=0.1 mM), but not by Pi; it is hardly inhibited by orthovanadate, quickly dissipated by monensink 2=18 nM), nigericin (k 1/2=25 nM), and sluggishly by N-ethylmaleimide (k 1/2 35 muM).	Nigericin	230-239	keratin 1	Homo sapiens	241-244
24221516-3	1988	Formation of the pH gradient half-saturates at 0.3 mM MgATP, peaks at pH 7, and is competitively inhibited by ADP (k i<=0.1 mM), but not by Pi; it is hardly inhibited by orthovanadate, quickly dissipated by monensink 2=18 nM), nigericin (k 1/2=25 nM), and sluggishly by N-ethylmaleimide (k 1/2 35 muM).	Nigericin	230-239	keratin 1	Homo sapiens	291-294
24221516-3	1988	Formation of the pH gradient half-saturates at 0.3 mM MgATP, peaks at pH 7, and is competitively inhibited by ADP (k i<=0.1 mM), but not by Pi; it is hardly inhibited by orthovanadate, quickly dissipated by monensink 2=18 nM), nigericin (k 1/2=25 nM), and sluggishly by N-ethylmaleimide (k 1/2 35 muM).	Ethylmaleimide	273-289	keratin 1	Homo sapiens	241-244
24221516-3	1988	Formation of the pH gradient half-saturates at 0.3 mM MgATP, peaks at pH 7, and is competitively inhibited by ADP (k i<=0.1 mM), but not by Pi; it is hardly inhibited by orthovanadate, quickly dissipated by monensink 2=18 nM), nigericin (k 1/2=25 nM), and sluggishly by N-ethylmaleimide (k 1/2 35 muM).	Ethylmaleimide	273-289	keratin 1	Homo sapiens	291-294
24221516-4	1988	Inhibition by KNO3 (k 1/2 6.7 mM) is incomplete (60%).	potassium nitrate	14-18	keratin 1	Homo sapiens	20-23
24221516-5	1988	Uridine 5"-diphosphate (UDP)-glucose, UDP-galactose, but not UDP-mannose and the pertinent sugars, dissipate the ATP-generated pH gradient (k 1/2 10-20 mM UDP-glucose; optimum pH at 7.8).	Uridine Diphosphate Glucose	0-36	keratin 1	Homo sapiens	140-151
24221516-5	1988	Uridine 5"-diphosphate (UDP)-glucose, UDP-galactose, but not UDP-mannose and the pertinent sugars, dissipate the ATP-generated pH gradient (k 1/2 10-20 mM UDP-glucose; optimum pH at 7.8).	Uridine Diphosphate Galactose	38-51	keratin 1	Homo sapiens	140-151
24221516-5	1988	Uridine 5"-diphosphate (UDP)-glucose, UDP-galactose, but not UDP-mannose and the pertinent sugars, dissipate the ATP-generated pH gradient (k 1/2 10-20 mM UDP-glucose; optimum pH at 7.8).	Sugars	91-97	keratin 1	Homo sapiens	140-151
24221516-5	1988	Uridine 5"-diphosphate (UDP)-glucose, UDP-galactose, but not UDP-mannose and the pertinent sugars, dissipate the ATP-generated pH gradient (k 1/2 10-20 mM UDP-glucose; optimum pH at 7.8).	Adenosine Triphosphate	113-116	keratin 1	Homo sapiens	140-151
24221516-5	1988	Uridine 5"-diphosphate (UDP)-glucose, UDP-galactose, but not UDP-mannose and the pertinent sugars, dissipate the ATP-generated pH gradient (k 1/2 10-20 mM UDP-glucose; optimum pH at 7.8).	Uridine Diphosphate Glucose	155-166	keratin 1	Homo sapiens	140-151
24221516-7	1988	UDP-glucoseinduced Pi release from the GV saturates (k 1/2=1 mM UDP-glucose; optimum pH at 7) and is completely inhibited by the anion-channel blocker 4,4"-diisothiocyano-2,2"-stilbene disulfonic acid (DIDS;k 1/2=140 muM).	udp-glucoseinduced	0-18	keratin 1	Homo sapiens	53-56
24221516-7	1988	UDP-glucoseinduced Pi release from the GV saturates (k 1/2=1 mM UDP-glucose; optimum pH at 7) and is completely inhibited by the anion-channel blocker 4,4"-diisothiocyano-2,2"-stilbene disulfonic acid (DIDS;k 1/2=140 muM).	udp-glucoseinduced	0-18	keratin 1	Homo sapiens	207-210
24221516-7	1988	UDP-glucoseinduced Pi release from the GV saturates (k 1/2=1 mM UDP-glucose; optimum pH at 7) and is completely inhibited by the anion-channel blocker 4,4"-diisothiocyano-2,2"-stilbene disulfonic acid (DIDS;k 1/2=140 muM).	Uridine Diphosphate Glucose	0-11	keratin 1	Homo sapiens	53-56
24221516-7	1988	UDP-glucoseinduced Pi release from the GV saturates (k 1/2=1 mM UDP-glucose; optimum pH at 7) and is completely inhibited by the anion-channel blocker 4,4"-diisothiocyano-2,2"-stilbene disulfonic acid (DIDS;k 1/2=140 muM).	Uridine Diphosphate Glucose	0-11	keratin 1	Homo sapiens	207-210
24221516-7	1988	UDP-glucoseinduced Pi release from the GV saturates (k 1/2=1 mM UDP-glucose; optimum pH at 7) and is completely inhibited by the anion-channel blocker 4,4"-diisothiocyano-2,2"-stilbene disulfonic acid (DIDS;k 1/2=140 muM).	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	151-200	keratin 1	Homo sapiens	53-56
24221516-7	1988	UDP-glucoseinduced Pi release from the GV saturates (k 1/2=1 mM UDP-glucose; optimum pH at 7) and is completely inhibited by the anion-channel blocker 4,4"-diisothiocyano-2,2"-stilbene disulfonic acid (DIDS;k 1/2=140 muM).	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	151-200	keratin 1	Homo sapiens	207-210
2450142-6	1988	In keratinocytes cultured in delipidated serum, which show some expression of keratin 1 (67 kd) characteristic of normal maturation, TGF-beta reduces the incorporation of methionine into this keratin 1 and increases labeling of keratins 6 and 16.	Methionine	171-181	keratin 1	Homo sapiens	192-245
3116369-6	1987	Admixture of partially hardened red cells (0.03% glutaraldehyde for 30 min) with normal red cells at a constant total hematocrit caused increases of both K1 and K2.	Glutaral	49-63	keratin 1	Homo sapiens	154-163
2967179-9	1988	Substitution of phenylalanine(B25) of DPI with tyrosine, a substitution that actually increased the homology of this analog to IGF-I, resulted in a 4- to 5-fold increase in the relative apparent affinity of the analog for the type I IGF receptor (K1/2 = 31 +/- 4 nM).	Phenylalanine	16-29	keratin 1	Homo sapiens	247-256
2967179-9	1988	Substitution of phenylalanine(B25) of DPI with tyrosine, a substitution that actually increased the homology of this analog to IGF-I, resulted in a 4- to 5-fold increase in the relative apparent affinity of the analog for the type I IGF receptor (K1/2 = 31 +/- 4 nM).	3-aminodiphenyleneiodium	38-41	keratin 1	Homo sapiens	247-256
2967179-9	1988	Substitution of phenylalanine(B25) of DPI with tyrosine, a substitution that actually increased the homology of this analog to IGF-I, resulted in a 4- to 5-fold increase in the relative apparent affinity of the analog for the type I IGF receptor (K1/2 = 31 +/- 4 nM).	Tyrosine	47-55	keratin 1	Homo sapiens	247-256
2821651-1	1987	Plasminogen kringle 1+2+3 (K1-3) containing lysine-binding sites inhibited the reaction of plasmin with alpha 2-plasmin inhibitor (alpha 2PI), in a rate assay using a synthetic chromogenic substrate, S-2251.	Lysine	44-50	keratin 1	Homo sapiens	27-31
2821651-3	1987	These results suggest that K1-3 blocked the binding of alpha 2PI to the lysine-binding site of plasmin.	Lysine	72-78	keratin 1	Homo sapiens	27-31
3022641-4	1986	Two additional isolates (K-1 and K-3) recovered from patients who had failed ketoconazole therapy were 32- to 64-fold more resistant than the median of each drug for other isolates.	Ketoconazole	77-89	keratin 1	Homo sapiens	25-36
3593764-8	1987	All the rate constants involved in determining the Km and Kd of NADH (kcat, k1 and k-1) can be modified.	NAD	64-68	keratin 1	Homo sapiens	76-86
2869820-4	1986	The kinetically determined Kd of [3H]RAUW (mean K-1/mean K1) was 0.59 nM and 1.68 nM in cortex and spinal cord, respectively.	Tritium	34-36	keratin 1	Homo sapiens	48-59
3760859-2	1986	Production of hydrogen peroxide during glutathione autooxidation was catalyzed by traces of Fe+2 or Cu+2, and to a much lesser extent by Cu+1 and Ni+2, but not to a detectable extent by Na+1, K+1, Fe+3, Al+3, Cd+2, Zn+2, Ca+2, Mg+2, Mn+2, or Hg+2.	Hydrogen Peroxide	14-31	keratin 1	Homo sapiens	192-195
3760859-2	1986	Production of hydrogen peroxide during glutathione autooxidation was catalyzed by traces of Fe+2 or Cu+2, and to a much lesser extent by Cu+1 and Ni+2, but not to a detectable extent by Na+1, K+1, Fe+3, Al+3, Cd+2, Zn+2, Ca+2, Mg+2, Mn+2, or Hg+2.	Glutathione	39-50	keratin 1	Homo sapiens	192-195
6588052-2	1984	Nearly 90% of the unidirectional 42K+ influx could be inhibited by the cardiac glycoside ouabain with a Ki of 5 X 10(-8) M. This ouabain-sensitive component of influx rose as a saturating function of the extracellular K+ concentration with a K1/2 of 0.85 mM.	Glycosides	79-88	keratin 1	Homo sapiens	242-251
2858849-1	1985	Measurement of the rate of [gamma-32P]ATP binding (k1) and release (k-1) from catalytic sites on submitochondrial particles permitted calculation of the affinity constant in catalytic sites (k1 = K1/k1-1) of 10(12) M-1.	[gamma-32p	27-37	keratin 1	Homo sapiens	196-203
2858849-1	1985	Measurement of the rate of [gamma-32P]ATP binding (k1) and release (k-1) from catalytic sites on submitochondrial particles permitted calculation of the affinity constant in catalytic sites (k1 = K1/k1-1) of 10(12) M-1.	Adenosine Triphosphate	38-41	keratin 1	Homo sapiens	196-203
2578149-7	1985	Cytoplasmic inhibition immunofluorescence studies indicated that K-1-21 binding to STA in Sezary cells or T cell lines was inhibited by preincubation of the K-1-21 antibody with purified kappa-Bence Jones protein.	sta	83-86	keratin 1	Homo sapiens	65-68
2578149-7	1985	Cytoplasmic inhibition immunofluorescence studies indicated that K-1-21 binding to STA in Sezary cells or T cell lines was inhibited by preincubation of the K-1-21 antibody with purified kappa-Bence Jones protein.	sta	83-86	keratin 1	Homo sapiens	157-160
6089577-3	1984	The flux was a Michaelis-Menten function of sulfate concentration at each pH with K1/2SO4 = 4-10 mM.	Sulfates	44-51	keratin 1	Homo sapiens	82-89
6588052-2	1984	Nearly 90% of the unidirectional 42K+ influx could be inhibited by the cardiac glycoside ouabain with a Ki of 5 X 10(-8) M. This ouabain-sensitive component of influx rose as a saturating function of the extracellular K+ concentration with a K1/2 of 0.85 mM.	Ouabain	89-96	keratin 1	Homo sapiens	242-251
6588052-2	1984	Nearly 90% of the unidirectional 42K+ influx could be inhibited by the cardiac glycoside ouabain with a Ki of 5 X 10(-8) M. This ouabain-sensitive component of influx rose as a saturating function of the extracellular K+ concentration with a K1/2 of 0.85 mM.	Ouabain	129-136	keratin 1	Homo sapiens	242-251
6615809-4	1983	The values are log K1* = 7.8 and log K2* = 6.4 in 0.10 M N-(2-hydroxyethyl)piperazine-N"-2-ethanesulfonic acid and 15 mM bicarbonate, pH 7.4 at 25 degrees C. Titrations of the two forms of monoferric transferrin show that K1* corresponds to zinc binding to the C-terminal site and K2* corresponds to binding at the N-terminal site.	Bicarbonates	121-132	keratin 1	Homo sapiens	222-225
6447598-3	1980	In the presence of Ca2+, ATP phosphorylates the enzyme at a much lower concentration: K 1/2 = 100 nM.	Adenosine Triphosphate	25-28	keratin 1	Homo sapiens	86-100
6870785-2	1983	The initial steps on the myosin ATPase (EC 3.6.1.3) pathway are taken to be: (formula; see text) A two-step binding for ATP is assumed, but the evidence for it is unconvincing; because of the rapidity of the process unambiguous values for K1 and K2 are not available.	Adenosine Triphosphate	32-35	keratin 1	Homo sapiens	239-248
7236705-4	1981	In the case of cyanate methemoglobin we find the enthalpy and entropy differences between the high-spin and low-spin states to be deltaH = 600 +/- 40 cal x mol-1 and deltaS = 4.7 +/- 0.7 cal x mol-1 x K-1.	deltah	130-136	keratin 1	Homo sapiens	201-204
33889903-5	2021	Thermal conductivity values of 15.8 +- 0.8 W m-1 K-1 and 4.2 +- 0.3 W m-1 K-1 were measured for Si and SiGe nanowires, respectively, epitaxially grown on silicon microstructures.	Silicon	96-98	keratin 1	Homo sapiens	49-60
5077830-0	1972	Glycolipid derivatives of vitamin K 1 .	Glycolipids	0-10	keratin 1	Homo sapiens	34-37
6006474-0	1966	[Clinical use of vitamin K-1 in hearing disorders caused by kanamycin].	Kanamycin	60-69	keratin 1	Homo sapiens	25-28
14483974-0	1962	Oxidative phosphorylation in mitochondria from animals treated with 2-chloro-3-phytyl-1,4-naphthoquinone, an antagonist of vitamin K-1.	chloro-K	68-104	keratin 1	Homo sapiens	131-134
708003-0	1978	[Characteristics of the polysaccharide-containing somatic antigens isolated from the K-1 strain of the plague microbe and its antibiotic-resistant variants].	Polysaccharides	24-38	keratin 1	Homo sapiens	85-88
708003-1	1978	Immunochemical analysis of 2 polysaccharide-containing structures of the lypopolysaccharide of the plague causative agent (main somatic antigen and lipopolysaccharide) isolated from K-1 strain and a number of its antibiotic resistant mutants was carried out.	lypopolysaccharide	73-91	keratin 1	Homo sapiens	182-185
708003-3	1978	More significant changes associated with development of complex resistance, i.e. K-1 (Strr leads to Penr leads to Tetr) were accompanied by a decrease in the content of hexozamine and serological activity of the main somatic antigen determining the O-specificity of the lipopolysaccharide.	hexozamine	169-179	keratin 1	Homo sapiens	81-84
708003-4	1978	Defective changes in the monosaccharide composition and serological properties of both the main somatic antigen and the polysaccharide were observed in the yellow variant of the streptomycin resistant mutant K-1.	Monosaccharides	25-39	keratin 1	Homo sapiens	208-211
708003-4	1978	Defective changes in the monosaccharide composition and serological properties of both the main somatic antigen and the polysaccharide were observed in the yellow variant of the streptomycin resistant mutant K-1.	Polysaccharides	120-134	keratin 1	Homo sapiens	208-211
708003-4	1978	Defective changes in the monosaccharide composition and serological properties of both the main somatic antigen and the polysaccharide were observed in the yellow variant of the streptomycin resistant mutant K-1.	Streptomycin	178-190	keratin 1	Homo sapiens	208-211
15586-7	1977	pH dependent k2 and KS values were used to calculate values for k1 and k-1, the binding and debinding rate constants for the two p-nitrophenyl compounds.	Potassium	20-22	keratin 1	Homo sapiens	64-74
32189733-6	1973	If each molecule of decomposed dicumyl peroxide of molecular weight M d produces one cross-link in the rubber of specific volume   upsilon   r   , then it is predicted that S = 2 R ( 100 M d upsilon   r ) - 1  = 5.5535 x 10 - 3    Mdyn cm-2 phr-1 K-1, as compared with the experimental value 5.925 x 10-3.	dicumyl peroxide	31-47	keratin 1	Homo sapiens	247-250
33889903-5	2021	Thermal conductivity values of 15.8 +- 0.8 W m-1 K-1 and 4.2 +- 0.3 W m-1 K-1 were measured for Si and SiGe nanowires, respectively, epitaxially grown on silicon microstructures.	sige	103-107	keratin 1	Homo sapiens	49-60
32833274-3	2020	Thanks to the proper design of rigid backbones and rational adjustments of polar and bulky side groups, the polymer substrate exhibits excellent thermal and mechanical properties with thermal decomposition temperature (Td,5% ) of 430  C, upper operating temperature of over 300  C, coefficient of thermal expansion of 48 ppm K-1 , tensile strength of 103 MPa, and elastic modulus of 2.49 GPa.	Polymers	108-115	keratin 1	Homo sapiens	325-328
33670118-7	2021	In the presence of higher calcium concentrations, terminal differentiation of hiPSC-bKs was induced and markers KRT1 and IVL expressed.	Calcium	26-33	keratin 1	Homo sapiens	112-116
33402063-7	2022	The results show that the effective thermal conductivity and the heat capacity decrease with the reduction of the water content from 2.60 W m-1 K-1 and 2.52 J g-1 K-1 for a wet sludge to 1.71 W m-1 K-1 and 0.78 J g-1 K-1 for a dry sludge respectively.	Water	114-119	keratin 1	Homo sapiens	144-153
33402063-7	2022	The results show that the effective thermal conductivity and the heat capacity decrease with the reduction of the water content from 2.60 W m-1 K-1 and 2.52 J g-1 K-1 for a wet sludge to 1.71 W m-1 K-1 and 0.78 J g-1 K-1 for a dry sludge respectively.	Water	114-119	keratin 1	Homo sapiens	198-207
32805670-4	2021	The PCPF obtained with a porous carbon (PC) to polyaniline (PAN) mass ratio of 3:5 (PCPF-3) exhibited a rich pore structure, good hydrophilicity, low thermal conductivity (0.0413 W m-1 K-1), and excellent light absorption (96.1%).	pc	4-6	keratin 1	Homo sapiens	185-188
32805670-4	2021	The PCPF obtained with a porous carbon (PC) to polyaniline (PAN) mass ratio of 3:5 (PCPF-3) exhibited a rich pore structure, good hydrophilicity, low thermal conductivity (0.0413 W m-1 K-1), and excellent light absorption (96.1%).	pcpf	4-8	keratin 1	Homo sapiens	185-188
32618063-4	2021	The emission quantum yield and the maximum relative temperature sensitivity ( S m ) of emission lifetimes for the Eu(III)-Gd(III) polymer (Eu:Gd = 1:1, Phi tot = 52%, S m = 3.73% K -1 ) were higher than those for the pure Eu(III) coordination polymer ( Phi tot = 36%, S m = 2.70% K -1 ), respectively.	Polymers	130-137	keratin 1	Homo sapiens	179-183
32618063-4	2021	The emission quantum yield and the maximum relative temperature sensitivity ( S m ) of emission lifetimes for the Eu(III)-Gd(III) polymer (Eu:Gd = 1:1, Phi tot = 52%, S m = 3.73% K -1 ) were higher than those for the pure Eu(III) coordination polymer ( Phi tot = 36%, S m = 2.70% K -1 ), respectively.	Polymers	130-137	keratin 1	Homo sapiens	280-284
32820892-7	2020	Benefiting from the 3D nano-structural uniqueness of SSPCCs, the thermal conductivity of the SSPCC-2 was up to 1.15 W m-1 K-1, which represented a significant enhancement of 239.7% compared with that of pure PEG.	Polyethylene Glycols	208-211	keratin 1	Homo sapiens	122-125
32729869-1	2020	We showed a reversible bond-switching ferroelastic phase transition at near room temperature in a novel organic-inorganic hybrid, (Me3NNH2)2[Co(CN)6Na(H2O)], to afford a latent heat of 43.7 kJ kg-1 and a large entropy change of 146 J K-1 kg-1.	(me3nnh2)2	130-140	keratin 1	Homo sapiens	234-242
32729869-1	2020	We showed a reversible bond-switching ferroelastic phase transition at near room temperature in a novel organic-inorganic hybrid, (Me3NNH2)2[Co(CN)6Na(H2O)], to afford a latent heat of 43.7 kJ kg-1 and a large entropy change of 146 J K-1 kg-1.	co(cn)6na	141-150	keratin 1	Homo sapiens	234-242
32729869-1	2020	We showed a reversible bond-switching ferroelastic phase transition at near room temperature in a novel organic-inorganic hybrid, (Me3NNH2)2[Co(CN)6Na(H2O)], to afford a latent heat of 43.7 kJ kg-1 and a large entropy change of 146 J K-1 kg-1.	Water	151-154	keratin 1	Homo sapiens	234-242
32672784-2	2020	PAZ:PSS can achieve an overall conductivity up to 0.1 S cm-1, and an ion Seebeck coefficient as high as 4500 muV K-1, demonstrating that PAZ:PSS is another promising water-dispersible polymer for thermoelectrics.	Water	166-171	keratin 1	Homo sapiens	113-116
32842698-6	2020	With 11.3 wt% Lys@BNNP incorporated, the thermal conductivity of Lys@BNNP/PVA hydrogel composite was up to 0.91 W m-1K-1, increased by 78%, comparing to the neat PVA hydrogel.	Lysine	14-17	keratin 1	Homo sapiens	117-120
32842698-6	2020	With 11.3 wt% Lys@BNNP incorporated, the thermal conductivity of Lys@BNNP/PVA hydrogel composite was up to 0.91 W m-1K-1, increased by 78%, comparing to the neat PVA hydrogel.	Lysine	65-68	keratin 1	Homo sapiens	117-120
32785329-3	2020	BaMgSi and Ba2Mg3Si4 exhibited inherently ultra-low lattice thermal conductivity of 1.27-0.37 W m-1 K-1 in the range of 300-1000 K due to the bonding hierarchy and rattling Ba atoms.	ba2mg3si4	11-20	keratin 1	Homo sapiens	100-103
32785329-3	2020	BaMgSi and Ba2Mg3Si4 exhibited inherently ultra-low lattice thermal conductivity of 1.27-0.37 W m-1 K-1 in the range of 300-1000 K due to the bonding hierarchy and rattling Ba atoms.	Barium	0-2	keratin 1	Homo sapiens	100-103
32632426-5	2020	The coefficient of thermal expansion (CTE) and thermal distortion parameter (TDP) substantially decreased from 59.3 ppm  C-1 and 17.5 m K-1 of EPDM/AlN, to 39.7 ppm  C-1 and 8.4 m K-1 of EPDM/AlN/BN, representing reductions of 33 and 52%, respectively.	Carbon	38-39	keratin 1	Homo sapiens	136-139
32806500-6	2020	Higher calcium concentrations significantly stimulated the expression of the genes (e.g., KRT1 and IVL) involved in keratinocyte differentiation and, promoted cell proliferation.	Calcium	7-14	keratin 1	Homo sapiens	90-94
32678587-4	2020	Due to changes in the thermal population of the Stark sublevels, the Tb(III) and Dy(III) complexes can be used as efficient optical thermometers with maximum relative sensitivities of 1.57 and 2.03% K-1 for 3 and 4, respectively.	tb(iii)	69-76	keratin 1	Homo sapiens	199-214
32678587-4	2020	Due to changes in the thermal population of the Stark sublevels, the Tb(III) and Dy(III) complexes can be used as efficient optical thermometers with maximum relative sensitivities of 1.57 and 2.03% K-1 for 3 and 4, respectively.	dy(iii)	81-88	keratin 1	Homo sapiens	199-214
32593008-8	2020	The introduction of the alumina phase makes them stable until 1200-1400  C, maintaining low values of thermal conductivity at very high temperature (below 81 mW m-1 K-1).	Aluminum Oxide	24-31	keratin 1	Homo sapiens	165-168
32608457-3	2020	The reaction of iron(ii) chloride with NO leading to the formation of MNIC (mononitrosyl-iron-complex) and DNIC (dinitrosyl-iron-complex) led to activation parameters of DeltaH  = 55.4 +- 0.4 kJ mol-1 and DeltaS  = 13 +- 2 J K-1 mol-1 for MNIC and DeltaH  = 32 +- 6 kJ mol-1 and DeltaS  = -193 +- 21 J K-1 mol-1 for DNIC.	ferrous chloride	16-33	keratin 1	Homo sapiens	225-228
32049370-2	2020	We found a novel frameshift trucation mutation c.1596_1597insAT, p. Gly533Metfs*82 in exon7 (V2 tail domian) of KRT1, which replacing the glycine-serine-rich tail of KRT1 with the alanine-rich 75 amino acids, developed a mild IHCM phenotype.	Glycine	138-152	keratin 1	Homo sapiens	112-116
32049370-2	2020	We found a novel frameshift trucation mutation c.1596_1597insAT, p. Gly533Metfs*82 in exon7 (V2 tail domian) of KRT1, which replacing the glycine-serine-rich tail of KRT1 with the alanine-rich 75 amino acids, developed a mild IHCM phenotype.	Glycine	138-152	keratin 1	Homo sapiens	166-170
32049370-2	2020	We found a novel frameshift trucation mutation c.1596_1597insAT, p. Gly533Metfs*82 in exon7 (V2 tail domian) of KRT1, which replacing the glycine-serine-rich tail of KRT1 with the alanine-rich 75 amino acids, developed a mild IHCM phenotype.	Alanine	180-187	keratin 1	Homo sapiens	112-116
32049370-2	2020	We found a novel frameshift trucation mutation c.1596_1597insAT, p. Gly533Metfs*82 in exon7 (V2 tail domian) of KRT1, which replacing the glycine-serine-rich tail of KRT1 with the alanine-rich 75 amino acids, developed a mild IHCM phenotype.	Alanine	180-187	keratin 1	Homo sapiens	166-170
32608457-3	2020	The reaction of iron(ii) chloride with NO leading to the formation of MNIC (mononitrosyl-iron-complex) and DNIC (dinitrosyl-iron-complex) led to activation parameters of DeltaH  = 55.4 +- 0.4 kJ mol-1 and DeltaS  = 13 +- 2 J K-1 mol-1 for MNIC and DeltaH  = 32 +- 6 kJ mol-1 and DeltaS  = -193 +- 21 J K-1 mol-1 for DNIC.	ferrous chloride	16-33	keratin 1	Homo sapiens	302-305
32608457-3	2020	The reaction of iron(ii) chloride with NO leading to the formation of MNIC (mononitrosyl-iron-complex) and DNIC (dinitrosyl-iron-complex) led to activation parameters of DeltaH  = 55.4 +- 0.4 kJ mol-1 and DeltaS  = 13 +- 2 J K-1 mol-1 for MNIC and DeltaH  = 32 +- 6 kJ mol-1 and DeltaS  = -193 +- 21 J K-1 mol-1 for DNIC.	Iron	16-20	keratin 1	Homo sapiens	225-228
32608457-3	2020	The reaction of iron(ii) chloride with NO leading to the formation of MNIC (mononitrosyl-iron-complex) and DNIC (dinitrosyl-iron-complex) led to activation parameters of DeltaH  = 55.4 +- 0.4 kJ mol-1 and DeltaS  = 13 +- 2 J K-1 mol-1 for MNIC and DeltaH  = 32 +- 6 kJ mol-1 and DeltaS  = -193 +- 21 J K-1 mol-1 for DNIC.	Iron	16-20	keratin 1	Homo sapiens	302-305
32608457-3	2020	The reaction of iron(ii) chloride with NO leading to the formation of MNIC (mononitrosyl-iron-complex) and DNIC (dinitrosyl-iron-complex) led to activation parameters of DeltaH  = 55.4 +- 0.4 kJ mol-1 and DeltaS  = 13 +- 2 J K-1 mol-1 for MNIC and DeltaH  = 32 +- 6 kJ mol-1 and DeltaS  = -193 +- 21 J K-1 mol-1 for DNIC.	Iron	89-93	keratin 1	Homo sapiens	225-228
32608457-3	2020	The reaction of iron(ii) chloride with NO leading to the formation of MNIC (mononitrosyl-iron-complex) and DNIC (dinitrosyl-iron-complex) led to activation parameters of DeltaH  = 55.4 +- 0.4 kJ mol-1 and DeltaS  = 13 +- 2 J K-1 mol-1 for MNIC and DeltaH  = 32 +- 6 kJ mol-1 and DeltaS  = -193 +- 21 J K-1 mol-1 for DNIC.	Iron	89-93	keratin 1	Homo sapiens	302-305
32461580-4	2020	The crystalline graphene paper exhibits superior mechanical (tensile strength of 1.1 GPa, stiffness of 62.8 GPa) and conductive properties (electrical conductivity of 1.1 x 105 S m-1, thermal conductivity of 109.11 W m-1 K-1).	Graphite	16-24	keratin 1	Homo sapiens	221-224
32240900-8	2020	The weight loss of WF1 being 2.2% and the average thermal expansion co-efficient (alphaavg) of 10.7 +- 1.2 x 10-6 K-1 in the temperature range (298-973 K) were comparatively lower than the parent phase, LaSr4(PO4)3O.	alphaavg	82-90	keratin 1	Homo sapiens	114-117
32620830-3	2020	Here we directly measured thermal conductivities of solid Fe and Fe-Si alloys up to 144 GPa and 3300 K. 15 at% Si alloyed in Fe substantially reduces its conductivity by about 2 folds at 132 GPa and 3000 K. An outer core with 15 at% Si would have a conductivity of about 20 W m-1 K-1, lower than pure Fe at similar pressure-temperature conditions.	Silicon	111-113	keratin 1	Homo sapiens	280-283
32620830-3	2020	Here we directly measured thermal conductivities of solid Fe and Fe-Si alloys up to 144 GPa and 3300 K. 15 at% Si alloyed in Fe substantially reduces its conductivity by about 2 folds at 132 GPa and 3000 K. An outer core with 15 at% Si would have a conductivity of about 20 W m-1 K-1, lower than pure Fe at similar pressure-temperature conditions.	Silicon	111-113	keratin 1	Homo sapiens	280-283
32537621-5	2020	Thermal conductivity decreases with graphene addition and can significantly reduce to as low as ~0.18 W m-1 K-1, resulting in an enhanced figure of merit (ZT) of the SnSe/graphene composite by at least 50% compared with pristine SnSe.	Graphite	36-44	keratin 1	Homo sapiens	108-111
32537621-5	2020	Thermal conductivity decreases with graphene addition and can significantly reduce to as low as ~0.18 W m-1 K-1, resulting in an enhanced figure of merit (ZT) of the SnSe/graphene composite by at least 50% compared with pristine SnSe.	Graphite	171-179	keratin 1	Homo sapiens	108-111
32437119-4	2020	The impressive thermal conductive performance: high in-plane thermal conductivity (28.8 W m-1 K-1) and low cross-plane thermal conductivity (0.27 W m-1 K-1), ingeniously enables highly efficient in-plane heat dissipation and cross-plane heat insulation in the MXene-based films simultaneously.	mxene	260-265	keratin 1	Homo sapiens	94-97
32437119-4	2020	The impressive thermal conductive performance: high in-plane thermal conductivity (28.8 W m-1 K-1) and low cross-plane thermal conductivity (0.27 W m-1 K-1), ingeniously enables highly efficient in-plane heat dissipation and cross-plane heat insulation in the MXene-based films simultaneously.	mxene	260-265	keratin 1	Homo sapiens	152-155
32310640-5	2020	These polymers exhibit red TADF at room temperature and blue fluorescence at 70  C, with a high ratiometric fluorescent thermal response of 32 +- 4% K-1.	Polymers	6-14	keratin 1	Homo sapiens	149-152
31995775-7	2020	In the arsenic-exposed group, miR-155-5p, keratin 1(Krt1), keratin 10 (Krt10), and keratin 6c (Krt6c) were significantly increased in the skin (p < 0.05), while NF-AT1, interleukin-2 (IL-2), and interferon-gamma (IFN-gamma) were significantly decreased (p < 0.05).	Arsenic	7-14	keratin 1	Homo sapiens	42-51
31995775-7	2020	In the arsenic-exposed group, miR-155-5p, keratin 1(Krt1), keratin 10 (Krt10), and keratin 6c (Krt6c) were significantly increased in the skin (p < 0.05), while NF-AT1, interleukin-2 (IL-2), and interferon-gamma (IFN-gamma) were significantly decreased (p < 0.05).	Arsenic	7-14	keratin 1	Homo sapiens	52-56
32018241-4	2020	Moreover, linear dependence on temperature of the zero-phonon line width in Si-doped crystals is 0.061(2) nm K-1 but is 0.047(3) nm K-1, about 35% smaller in Si,P-doped nanodiamonds.	Silicon	76-78	keratin 1	Homo sapiens	109-112
32018241-4	2020	Moreover, linear dependence on temperature of the zero-phonon line width in Si-doped crystals is 0.061(2) nm K-1 but is 0.047(3) nm K-1, about 35% smaller in Si,P-doped nanodiamonds.	Silicon	158-160	keratin 1	Homo sapiens	132-135
32252435-7	2020	We found that the titanium layer increased the TBC by a factor of 2, from 59 x 106 W m-2 K-1 to 115 x 106 W m-2 K-1, while the nickel layer increased TBC to 139 x 106 W m-2 K-1.	Titanium	18-26	keratin 1	Homo sapiens	89-92
32395573-7	2020	The corresponding microscopic dissociation constants for Cu2+-alphaB-crystallin complexes (K 1 and K 2) were found to be equal to 0.94 and 36 microM.	cupric ion	57-61	keratin 1	Homo sapiens	91-102
32395573-8	2020	For peroxynitrite modified alphaB-crystallin the K 1 and K 2 values are equal to 4.3 and 70 microM, respectively.	Peroxynitrous Acid	4-17	keratin 1	Homo sapiens	49-60
32252435-7	2020	We found that the titanium layer increased the TBC by a factor of 2, from 59 x 106 W m-2 K-1 to 115 x 106 W m-2 K-1, while the nickel layer increased TBC to 139 x 106 W m-2 K-1.	Titanium	18-26	keratin 1	Homo sapiens	112-115
32252435-7	2020	We found that the titanium layer increased the TBC by a factor of 2, from 59 x 106 W m-2 K-1 to 115 x 106 W m-2 K-1, while the nickel layer increased TBC to 139 x 106 W m-2 K-1.	Titanium	18-26	keratin 1	Homo sapiens	112-115
32252435-7	2020	We found that the titanium layer increased the TBC by a factor of 2, from 59 x 106 W m-2 K-1 to 115 x 106 W m-2 K-1, while the nickel layer increased TBC to 139 x 106 W m-2 K-1.	tbc	47-50	keratin 1	Homo sapiens	89-92
32252435-7	2020	We found that the titanium layer increased the TBC by a factor of 2, from 59 x 106 W m-2 K-1 to 115 x 106 W m-2 K-1, while the nickel layer increased TBC to 139 x 106 W m-2 K-1.	tbc	47-50	keratin 1	Homo sapiens	112-115
32252435-7	2020	We found that the titanium layer increased the TBC by a factor of 2, from 59 x 106 W m-2 K-1 to 115 x 106 W m-2 K-1, while the nickel layer increased TBC to 139 x 106 W m-2 K-1.	tbc	47-50	keratin 1	Homo sapiens	112-115
32226330-3	2020	Cys401K10 formed a disulfide-linkage with Cys401 from another K1/10 heterodimer, creating an "X-shaped" structure and a loose crystal packing arrangement.	cys401k10	0-9	keratin 1	Homo sapiens	62-67
32256770-10	2020	The mRNA and protein expression levels of keratin 1 and involucrin were significantly decreased following interference of MVK expression, and the decrease was markedly attenuated by FPP.	farnesyl pyrophosphate	182-185	keratin 1	Homo sapiens	42-51
32226330-3	2020	Cys401K10 formed a disulfide-linkage with Cys401 from another K1/10 heterodimer, creating an "X-shaped" structure and a loose crystal packing arrangement.	Disulfides	19-28	keratin 1	Homo sapiens	62-67
32226330-8	2020	We postulated that elimination of the disulfide linkage in the K1/K10(Cys401Ala) 2B structure could allow for the 2B heterodimers to bind/pack in the A22 tetramer configuration associated with mature keratin intermediate filament assembly.	Disulfides	38-47	keratin 1	Homo sapiens	63-69
32097550-6	2020	MXene can enhance the Seebeck coefficient from 23 up to 57.3 microV K-1 and the power factor from 44.1 up to 155 microW m-1 K-2.	mxene	0-5	keratin 1	Homo sapiens	68-71
31929050-4	2020	The ratio of the first-order rate coefficient of fumarate to nitrate (k1,fum/k1,NO3) was obtained to estimate the amount and frequency of fumarate injection for the effective design of WDB.	Fumarates	49-57	keratin 1	Homo sapiens	77-83
32179842-7	2020	Furthermore, retinoid regulation of differentiation-specific keratins involves post-transcriptional mechanisms as we show KRT2 mRNA is stabilised whilst KRT1 and KRT10 mRNAs are destabilised in the presence of ATRA.	Retinoids	13-21	keratin 1	Homo sapiens	153-157
31929050-4	2020	The ratio of the first-order rate coefficient of fumarate to nitrate (k1,fum/k1,NO3) was obtained to estimate the amount and frequency of fumarate injection for the effective design of WDB.	Nitrates	61-68	keratin 1	Homo sapiens	77-83
31929050-4	2020	The ratio of the first-order rate coefficient of fumarate to nitrate (k1,fum/k1,NO3) was obtained to estimate the amount and frequency of fumarate injection for the effective design of WDB.	Fumarates	138-146	keratin 1	Homo sapiens	77-83
31179457-6	2019	Accordingly, based on the fluorescence intensity ratio (FIR) of the luminescence of Mn4+ and Eu3+, the optimal relative sensitivity of temperature sensing in the BLN and CLN matrices could reach 2.08% K-1 and 1.51% K-1, respectively.	mn4+	84-88	keratin 1	Homo sapiens	201-210
30169967-4	2020	Compounds K1 and 2 showed excellent antioxidant DPPH free radical scavenging activity with IC50 values of 4.61 and 4.12 microg/mL compared to ascorbic acid as a standard antioxidant drug with IC50 value of 3.42 microg/mL, respectively.	dpph free radical	48-65	keratin 1	Homo sapiens	10-18
30169967-4	2020	Compounds K1 and 2 showed excellent antioxidant DPPH free radical scavenging activity with IC50 values of 4.61 and 4.12 microg/mL compared to ascorbic acid as a standard antioxidant drug with IC50 value of 3.42 microg/mL, respectively.	Ascorbic Acid	142-155	keratin 1	Homo sapiens	10-18
30169967-5	2020	Evaluation of in vitro cytotoxic activities of compounds K1 and 2 showed significant effects against human oral cancer cell lines (AW13516 and AW8507), human hepatoma cell lines (HEPG2 and PLC-PRF-5) and a human pancreatic cell line (MIA-PA-CA-2), compared to Doxorubicin  as a standard cytotoxic drug with GI50 values of &lt;10 and 18.18 microg/mL.	Doxorubicin	260-271	keratin 1	Homo sapiens	57-65
31986003-5	2020	In addition, Sn-rich and Ag-rich particles/areas observed in the matrix of Sn0.98Na0.016Ag0.004Se contribute to the reduction of lattice thermal conductivity from 0.61 W m-1 K-1 for Sn0.98Ag0.02Se to 0.47 W m-1 K-1 at 785 K. The combination of simultaneously enhanced power factor and depressed thermal conductivity leads to a maximum ZT ~1.2 at 785 K and a high average ZT ~0.74 at 335-785 K for Sn0.98Na0.016Ag0.004Se, and generating a high theoretical conversion efficiency of ~11%.	Tin	13-15	keratin 1	Homo sapiens	174-177
31986003-5	2020	In addition, Sn-rich and Ag-rich particles/areas observed in the matrix of Sn0.98Na0.016Ag0.004Se contribute to the reduction of lattice thermal conductivity from 0.61 W m-1 K-1 for Sn0.98Ag0.02Se to 0.47 W m-1 K-1 at 785 K. The combination of simultaneously enhanced power factor and depressed thermal conductivity leads to a maximum ZT ~1.2 at 785 K and a high average ZT ~0.74 at 335-785 K for Sn0.98Na0.016Ag0.004Se, and generating a high theoretical conversion efficiency of ~11%.	Tin	13-15	keratin 1	Homo sapiens	211-214
31986003-5	2020	In addition, Sn-rich and Ag-rich particles/areas observed in the matrix of Sn0.98Na0.016Ag0.004Se contribute to the reduction of lattice thermal conductivity from 0.61 W m-1 K-1 for Sn0.98Ag0.02Se to 0.47 W m-1 K-1 at 785 K. The combination of simultaneously enhanced power factor and depressed thermal conductivity leads to a maximum ZT ~1.2 at 785 K and a high average ZT ~0.74 at 335-785 K for Sn0.98Na0.016Ag0.004Se, and generating a high theoretical conversion efficiency of ~11%.	Tin	75-77	keratin 1	Homo sapiens	174-177
31986003-5	2020	In addition, Sn-rich and Ag-rich particles/areas observed in the matrix of Sn0.98Na0.016Ag0.004Se contribute to the reduction of lattice thermal conductivity from 0.61 W m-1 K-1 for Sn0.98Ag0.02Se to 0.47 W m-1 K-1 at 785 K. The combination of simultaneously enhanced power factor and depressed thermal conductivity leads to a maximum ZT ~1.2 at 785 K and a high average ZT ~0.74 at 335-785 K for Sn0.98Na0.016Ag0.004Se, and generating a high theoretical conversion efficiency of ~11%.	Tin	75-77	keratin 1	Homo sapiens	211-214
31986003-5	2020	In addition, Sn-rich and Ag-rich particles/areas observed in the matrix of Sn0.98Na0.016Ag0.004Se contribute to the reduction of lattice thermal conductivity from 0.61 W m-1 K-1 for Sn0.98Ag0.02Se to 0.47 W m-1 K-1 at 785 K. The combination of simultaneously enhanced power factor and depressed thermal conductivity leads to a maximum ZT ~1.2 at 785 K and a high average ZT ~0.74 at 335-785 K for Sn0.98Na0.016Ag0.004Se, and generating a high theoretical conversion efficiency of ~11%.	Tin	75-77	keratin 1	Homo sapiens	174-177
31986003-5	2020	In addition, Sn-rich and Ag-rich particles/areas observed in the matrix of Sn0.98Na0.016Ag0.004Se contribute to the reduction of lattice thermal conductivity from 0.61 W m-1 K-1 for Sn0.98Ag0.02Se to 0.47 W m-1 K-1 at 785 K. The combination of simultaneously enhanced power factor and depressed thermal conductivity leads to a maximum ZT ~1.2 at 785 K and a high average ZT ~0.74 at 335-785 K for Sn0.98Na0.016Ag0.004Se, and generating a high theoretical conversion efficiency of ~11%.	Tin	75-77	keratin 1	Homo sapiens	211-214
31986003-5	2020	In addition, Sn-rich and Ag-rich particles/areas observed in the matrix of Sn0.98Na0.016Ag0.004Se contribute to the reduction of lattice thermal conductivity from 0.61 W m-1 K-1 for Sn0.98Ag0.02Se to 0.47 W m-1 K-1 at 785 K. The combination of simultaneously enhanced power factor and depressed thermal conductivity leads to a maximum ZT ~1.2 at 785 K and a high average ZT ~0.74 at 335-785 K for Sn0.98Na0.016Ag0.004Se, and generating a high theoretical conversion efficiency of ~11%.	Tin	75-77	keratin 1	Homo sapiens	174-177
31986003-5	2020	In addition, Sn-rich and Ag-rich particles/areas observed in the matrix of Sn0.98Na0.016Ag0.004Se contribute to the reduction of lattice thermal conductivity from 0.61 W m-1 K-1 for Sn0.98Ag0.02Se to 0.47 W m-1 K-1 at 785 K. The combination of simultaneously enhanced power factor and depressed thermal conductivity leads to a maximum ZT ~1.2 at 785 K and a high average ZT ~0.74 at 335-785 K for Sn0.98Na0.016Ag0.004Se, and generating a high theoretical conversion efficiency of ~11%.	Tin	75-77	keratin 1	Homo sapiens	211-214
31855411-5	2020	Remarkably, the (RGO/fSWCNT)1:2.5 epoxy nanocomposite reaches the thermal conductivity of 0.63 to 0.69 W m-1 K-1 from 300 to 390 K at a very low filler loading of 3.65 vol%, which is more than 4 times enhancement over the pure epoxy resin.	Epoxy Compounds	34-39	keratin 1	Homo sapiens	109-112
31430722-4	2019	The thermal conductance varies from 0.24 to 1.00 nW K-1 at 300 K, and phonon transport in the linear benzene polymers and carbon nanothreads is strongly dependent on the connectivity styles between the benzene rings.	Benzene	101-108	keratin 1	Homo sapiens	52-55
31430722-4	2019	The thermal conductance varies from 0.24 to 1.00 nW K-1 at 300 K, and phonon transport in the linear benzene polymers and carbon nanothreads is strongly dependent on the connectivity styles between the benzene rings.	Polymers	109-117	keratin 1	Homo sapiens	52-55
31859474-12	2020	We achieve a thermal conductivity of 16 W m-1 K-1 at a pressure below 0.2 MPa for capsules treated with dodecanethiol and hydrochloric acid.	dodecylmercaptan	104-117	keratin 1	Homo sapiens	46-49
31859474-12	2020	We achieve a thermal conductivity of 16 W m-1 K-1 at a pressure below 0.2 MPa for capsules treated with dodecanethiol and hydrochloric acid.	Hydrochloric Acid	122-139	keratin 1	Homo sapiens	46-49
31626526-0	2019	High-Performance Pr3+-Doped Scandate Optical Thermometry: 200 K of Sensing Range with Relative Temperature Sensitivity above 2% K-1.	Praseodymium	17-21	keratin 1	Homo sapiens	128-131
31626526-5	2019	The obtained experimental results manifest that Pr3+:CaSc2O4 owns a maximum relative temperature sensitivity Sr of 2.49% K-1 (at 390 K) and a low temperature uncertainty (around 0.1 K from 275 to 490 K).	Praseodymium	48-52	keratin 1	Homo sapiens	121-124
31626526-5	2019	The obtained experimental results manifest that Pr3+:CaSc2O4 owns a maximum relative temperature sensitivity Sr of 2.49% K-1 (at 390 K) and a low temperature uncertainty (around 0.1 K from 275 to 490 K).	Scandium	53-60	keratin 1	Homo sapiens	121-124
31626526-5	2019	The obtained experimental results manifest that Pr3+:CaSc2O4 owns a maximum relative temperature sensitivity Sr of 2.49% K-1 (at 390 K) and a low temperature uncertainty (around 0.1 K from 275 to 490 K).	Strontium	109-111	keratin 1	Homo sapiens	121-124
31659489-2	2019	The ratio of the emissions of Cu(II) and Mn(II) ions in the microparticles is highly temperature dependent in the range from 298 to 498 K. The best absolute and relative sensitivities are 0.547 K-1 and 0.525% K-1, respectively.	Copper	30-36	keratin 1	Homo sapiens	194-197
31659489-2	2019	The ratio of the emissions of Cu(II) and Mn(II) ions in the microparticles is highly temperature dependent in the range from 298 to 498 K. The best absolute and relative sensitivities are 0.547 K-1 and 0.525% K-1, respectively.	Copper	30-36	keratin 1	Homo sapiens	209-212
31659489-2	2019	The ratio of the emissions of Cu(II) and Mn(II) ions in the microparticles is highly temperature dependent in the range from 298 to 498 K. The best absolute and relative sensitivities are 0.547 K-1 and 0.525% K-1, respectively.	Manganese	41-47	keratin 1	Homo sapiens	194-197
31659489-2	2019	The ratio of the emissions of Cu(II) and Mn(II) ions in the microparticles is highly temperature dependent in the range from 298 to 498 K. The best absolute and relative sensitivities are 0.547 K-1 and 0.525% K-1, respectively.	Manganese	41-47	keratin 1	Homo sapiens	209-212
31179457-6	2019	Accordingly, based on the fluorescence intensity ratio (FIR) of the luminescence of Mn4+ and Eu3+, the optimal relative sensitivity of temperature sensing in the BLN and CLN matrices could reach 2.08% K-1 and 1.51% K-1, respectively.	mn4+	84-88	keratin 1	Homo sapiens	201-204
31179457-6	2019	Accordingly, based on the fluorescence intensity ratio (FIR) of the luminescence of Mn4+ and Eu3+, the optimal relative sensitivity of temperature sensing in the BLN and CLN matrices could reach 2.08% K-1 and 1.51% K-1, respectively.	eu3+	93-97	keratin 1	Homo sapiens	201-210
31179457-6	2019	Accordingly, based on the fluorescence intensity ratio (FIR) of the luminescence of Mn4+ and Eu3+, the optimal relative sensitivity of temperature sensing in the BLN and CLN matrices could reach 2.08% K-1 and 1.51% K-1, respectively.	eu3+	93-97	keratin 1	Homo sapiens	201-204
31179457-6	2019	Accordingly, based on the fluorescence intensity ratio (FIR) of the luminescence of Mn4+ and Eu3+, the optimal relative sensitivity of temperature sensing in the BLN and CLN matrices could reach 2.08% K-1 and 1.51% K-1, respectively.	colostrinine	170-173	keratin 1	Homo sapiens	201-210
31179457-6	2019	Accordingly, based on the fluorescence intensity ratio (FIR) of the luminescence of Mn4+ and Eu3+, the optimal relative sensitivity of temperature sensing in the BLN and CLN matrices could reach 2.08% K-1 and 1.51% K-1, respectively.	colostrinine	170-173	keratin 1	Homo sapiens	201-204
30641059-6	2019	MS analysis indicated that leukamenin E could covalently modify amino acid residue(s) in a synthetic peptide based on keratin 1 and keratin 10 sequences, suggesting that covalent modification of the synthetic peptide by leukamenin E caused assembly inhibition or disrupted KF polymerization in HepG2 and NCI-H1299 cells.	leukamenin	27-37	keratin 1	Homo sapiens	118-127
31280719-3	2019	The too large thermal conductivity approximately equal to 10.5 W m-1 K-1 at room temperature prevents this pyrite from being a good thermoelectric material.	pyrite	107-113	keratin 1	Homo sapiens	69-72
31005366-4	2019	Ginnalin B dose-dependently increased the relative amount of keratin 10, keratin 1, and filaggrin gene, with maximal increase of 1.7-, 2.9, and 5.2-fold at 100 muM, respectively.	6-O-galloyl-1,5-anhydroglucitol	0-10	keratin 1	Homo sapiens	61-70
31166922-5	2019	A relative dielectric constant of 46 with a temperature coefficient of 57 ppm K-1 in the temperature range 297-448 K was measured for a polycrystalline ceramic sample at 150 Hz-1 MHz with a dielectric loss tan delta of less than 0.01.	polycrystalline	136-151	keratin 1	Homo sapiens	78-81
30791399-0	2019	Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease.	Vitamin K	0-9	keratin 1	Homo sapiens	85-94
30792099-10	2019	Also, DHT suppressed cytokeratin 1 and cytokeratin 10, in fibroblast-keratinocyte co-culture similarly to the effect of FGF10 to hKC.	Dihydrotestosterone	6-9	keratin 1	Homo sapiens	21-34
30357932-11	2019	In addition, tofacitinib upregulated DSC1, FLG and KRT1.	tofacitinib	13-24	keratin 1	Homo sapiens	51-55
30764551-5	2019	RESULTS: gamma-PSL (1 to 100 mug/mL) triggered keratinocytes, in a concentration-dependent manner, into the terminal differentiation, as shown by the increased protein expression of cytokeratin 1 (KRT1).	gamma-psl	9-18	keratin 1	Homo sapiens	182-195
30764551-5	2019	RESULTS: gamma-PSL (1 to 100 mug/mL) triggered keratinocytes, in a concentration-dependent manner, into the terminal differentiation, as shown by the increased protein expression of cytokeratin 1 (KRT1).	gamma-psl	9-18	keratin 1	Homo sapiens	197-201
30640324-6	2019	The single cathode potential temperature coefficients, estimated in such a way, were positive (dphi(LiMn2O4)/dT = 0.86 mV K-1, dphi(LiFePO4)/dT = 0.86 mV K-1 and dphi(LiCoO2)/dT = 0.83 mV K-1).	dphi	95-99	keratin 1	Homo sapiens	122-125
30640324-6	2019	The single cathode potential temperature coefficients, estimated in such a way, were positive (dphi(LiMn2O4)/dT = 0.86 mV K-1, dphi(LiFePO4)/dT = 0.86 mV K-1 and dphi(LiCoO2)/dT = 0.83 mV K-1).	Thymidine	109-111	keratin 1	Homo sapiens	122-125
30640324-10	2019	The dphiLi/dT value was 1.03 mV K-1.	dphili	4-10	keratin 1	Homo sapiens	32-35
30622265-2	2019	Here we report that, under the temperature gradient applied simultaneously to both parallel and perpendicular directions of measurement, a metallic copper selenide, Cu2Se, shows two sign reversals and colossal values of S exceeding +-2 mV K-1 in a narrow temperature range, 340 K &lt; T &lt; 400 K, where a structure phase transition takes place.	copper selenide	148-163	keratin 1	Homo sapiens	239-242
30640324-10	2019	The dphiLi/dT value was 1.03 mV K-1.	Thymidine	11-13	keratin 1	Homo sapiens	32-35
30640324-11	2019	The measured difference in the dphi/dT values for metallic lithium and graphite (LiC6) anodes was small (dE/dT = dphi(C6Li)/dT - dphiLi/dT = -0.08 mV K-1).	dphi	31-35	keratin 1	Homo sapiens	150-153
30640324-11	2019	The measured difference in the dphi/dT values for metallic lithium and graphite (LiC6) anodes was small (dE/dT = dphi(C6Li)/dT - dphiLi/dT = -0.08 mV K-1).	Thymidine	36-38	keratin 1	Homo sapiens	150-153
30640324-11	2019	The measured difference in the dphi/dT values for metallic lithium and graphite (LiC6) anodes was small (dE/dT = dphi(C6Li)/dT - dphiLi/dT = -0.08 mV K-1).	Lithium	59-66	keratin 1	Homo sapiens	150-153
30640324-11	2019	The measured difference in the dphi/dT values for metallic lithium and graphite (LiC6) anodes was small (dE/dT = dphi(C6Li)/dT - dphiLi/dT = -0.08 mV K-1).	Graphite	71-79	keratin 1	Homo sapiens	150-153
30640324-11	2019	The measured difference in the dphi/dT values for metallic lithium and graphite (LiC6) anodes was small (dE/dT = dphi(C6Li)/dT - dphiLi/dT = -0.08 mV K-1).	Thymidine	108-110	keratin 1	Homo sapiens	150-153
30640324-11	2019	The measured difference in the dphi/dT values for metallic lithium and graphite (LiC6) anodes was small (dE/dT = dphi(C6Li)/dT - dphiLi/dT = -0.08 mV K-1).	Thymidine	108-110	keratin 1	Homo sapiens	150-153
30622265-2	2019	Here we report that, under the temperature gradient applied simultaneously to both parallel and perpendicular directions of measurement, a metallic copper selenide, Cu2Se, shows two sign reversals and colossal values of S exceeding +-2 mV K-1 in a narrow temperature range, 340 K &lt; T &lt; 400 K, where a structure phase transition takes place.	cu2se	165-170	keratin 1	Homo sapiens	239-242
30265270-4	2018	The temperature coefficient of resistance of our films is much greater than the reported values for pristine carbon nanotubes, up to -2.8% K-1 at liquid nitrogen temperature.	Carbon	109-115	keratin 1	Homo sapiens	139-142
30501322-5	2018	At the micrometer scale, thermoelectric characterization of the mesoporous Si (50 mum thickness) was achieved and results gave very promising values (S   700 muV K-1) for micro-thermo-generator fabrication.	Silicon	75-77	keratin 1	Homo sapiens	162-165
30595211-0	2019	Cytoprotective and genotoxic effects of vitamins K1 and B1 on irinotecan in vitro.	Irinotecan	62-72	keratin 1	Homo sapiens	49-58
30292111-1	2018	A new theoretical method was established for the combinatorial calculation of the dissociation rate constant (K-1) of the metal-organic complexes (MLs), the concentration of free ionic soil metals (CM), the labile concentration of soil metal-organic complexes (CML) based on diffusive gradients in thin-films (DGT) technique with a range of diffusive layer thicknesses (0.053-0.173 mm) in soils.	Metals	122-127	keratin 1	Homo sapiens	110-113
30292111-4	2018	According to the results of model fitting, cation exchange capacity and soil organic matter were found to be the key environmental factors for K-1 values of Cd and Ni, respectively.	Cadmium	157-159	keratin 1	Homo sapiens	143-146
29083128-16	2018	CONCLUSIONS: The data obtained here indicate that K-1 fighters need to improve tolerance to lactate accumulation to perform greater number of actions.	Lactic Acid	92-99	keratin 1	Homo sapiens	50-53
30410120-7	2018	Magnetic entropy change DeltaSm ~-18.5 J kg-1 K-1 with relatively concentrated WTI and WTI up to ~60 K with net refrigeration capacity ~240 J kg-1 at 50 kOe are demonstrated in the present Ni-Mn-Ga microwires.	ni-mn	189-194	keratin 1	Homo sapiens	46-49
30410120-7	2018	Magnetic entropy change DeltaSm ~-18.5 J kg-1 K-1 with relatively concentrated WTI and WTI up to ~60 K with net refrigeration capacity ~240 J kg-1 at 50 kOe are demonstrated in the present Ni-Mn-Ga microwires.	Gallium	195-197	keratin 1	Homo sapiens	46-49
30265270-4	2018	The temperature coefficient of resistance of our films is much greater than the reported values for pristine carbon nanotubes, up to -2.8% K-1 at liquid nitrogen temperature.	Nitrogen	153-161	keratin 1	Homo sapiens	139-142
29979868-3	2018	The modified materials were then treated with Rh(acac)(CO)2, giving the catalysts K-1 and K-2.	rh(acac)	46-54	keratin 1	Homo sapiens	82-85
30212199-4	2018	Meanwhile, we found that the lattice thermal conductivity kappal can be reduced from ~0.77 Wm-1 K-1 in PbTe to ~0.45 Wm-1 K-1 in (Pb0.91Sn0.09)(Te0.91Se0.09) by producing point defects via Sn and Se co-alloying.	Lead telluride	103-107	keratin 1	Homo sapiens	96-99
30212199-4	2018	Meanwhile, we found that the lattice thermal conductivity kappal can be reduced from ~0.77 Wm-1 K-1 in PbTe to ~0.45 Wm-1 K-1 in (Pb0.91Sn0.09)(Te0.91Se0.09) by producing point defects via Sn and Se co-alloying.	Lead telluride	103-107	keratin 1	Homo sapiens	122-125
30212199-4	2018	Meanwhile, we found that the lattice thermal conductivity kappal can be reduced from ~0.77 Wm-1 K-1 in PbTe to ~0.45 Wm-1 K-1 in (Pb0.91Sn0.09)(Te0.91Se0.09) by producing point defects via Sn and Se co-alloying.	Selenium	150-152	keratin 1	Homo sapiens	96-99
30212199-4	2018	Meanwhile, we found that the lattice thermal conductivity kappal can be reduced from ~0.77 Wm-1 K-1 in PbTe to ~0.45 Wm-1 K-1 in (Pb0.91Sn0.09)(Te0.91Se0.09) by producing point defects via Sn and Se co-alloying.	Selenium	150-152	keratin 1	Homo sapiens	122-125
30127398-3	2018	Here, we demonstrate large room-temperature mechanocaloric effects in the absence of any structural phase transformation in the fast-ion conductor Li3N ( DeltaS  ~ 25 J K-1 kg-1 and  DeltaT  ~ 5 K).	Lithium nitride	147-151	keratin 1	Homo sapiens	169-177
29979868-3	2018	The modified materials were then treated with Rh(acac)(CO)2, giving the catalysts K-1 and K-2.	co)2	55-59	keratin 1	Homo sapiens	82-85
29979868-8	2018	Catalyst K-1 is reusable and can be applied to the hydroformylation of linear olefins, styrene, 4-vinylcyclohexene, and dienes, as well as representative terpenes and other unsaturated hydrocarbons in a batch reactor.	Alkenes	78-85	keratin 1	Homo sapiens	9-12
29979868-8	2018	Catalyst K-1 is reusable and can be applied to the hydroformylation of linear olefins, styrene, 4-vinylcyclohexene, and dienes, as well as representative terpenes and other unsaturated hydrocarbons in a batch reactor.	Styrene	87-94	keratin 1	Homo sapiens	9-12
29979868-8	2018	Catalyst K-1 is reusable and can be applied to the hydroformylation of linear olefins, styrene, 4-vinylcyclohexene, and dienes, as well as representative terpenes and other unsaturated hydrocarbons in a batch reactor.	4-vinylcyclohexene	96-114	keratin 1	Homo sapiens	9-12
29979868-8	2018	Catalyst K-1 is reusable and can be applied to the hydroformylation of linear olefins, styrene, 4-vinylcyclohexene, and dienes, as well as representative terpenes and other unsaturated hydrocarbons in a batch reactor.	dienes	120-126	keratin 1	Homo sapiens	9-12
29979868-8	2018	Catalyst K-1 is reusable and can be applied to the hydroformylation of linear olefins, styrene, 4-vinylcyclohexene, and dienes, as well as representative terpenes and other unsaturated hydrocarbons in a batch reactor.	Terpenes	154-162	keratin 1	Homo sapiens	9-12
29979868-8	2018	Catalyst K-1 is reusable and can be applied to the hydroformylation of linear olefins, styrene, 4-vinylcyclohexene, and dienes, as well as representative terpenes and other unsaturated hydrocarbons in a batch reactor.	unsaturated hydrocarbons	173-197	keratin 1	Homo sapiens	9-12
30026506-2	2018	Previous studies show that NifB couples a putative pair of [Fe4S4] modules (designated K1 and K2) into an [Fe8S9C] cofactor precursor concomitant with radical SAM-dependent carbide insertion through the action of its SAM-binding [Fe4S4] module.	nifb	27-31	keratin 1	Homo sapiens	87-96
29674144-11	2018	The two-site kinetic retention model and the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory suggested that the combination of k1/k1d, k2 and secondary minimum energy can be used to accurately describe the attachment of nTiO2-montmorillonite and diatomite to sand in the presence of P.	ntio2-montmorillonite	219-240	keratin 1	Homo sapiens	126-132
30026506-2	2018	Previous studies show that NifB couples a putative pair of [Fe4S4] modules (designated K1 and K2) into an [Fe8S9C] cofactor precursor concomitant with radical SAM-dependent carbide insertion through the action of its SAM-binding [Fe4S4] module.	carbide	173-180	keratin 1	Homo sapiens	87-96
29846055-3	2018	The UiO-66(Zr&amp;Eu) polymer films can be used for the detection of temperature changes in the range of 237-337 K due to the energy transfer between the lanthanide ions (Eu in clusters) and the luminescent ligands, and the relative sensitivity reaches 4.26% K-1 at 337 K. Moreover, the sensitivity can be improved to 19.67% K-1 by changing the film thickness.	Polymers	22-29	keratin 1	Homo sapiens	259-262
29846055-3	2018	The UiO-66(Zr&amp;Eu) polymer films can be used for the detection of temperature changes in the range of 237-337 K due to the energy transfer between the lanthanide ions (Eu in clusters) and the luminescent ligands, and the relative sensitivity reaches 4.26% K-1 at 337 K. Moreover, the sensitivity can be improved to 19.67% K-1 by changing the film thickness.	Polymers	22-29	keratin 1	Homo sapiens	325-328
29182275-3	2017	Cu performs several outstanding roles: Cu atoms fill the Pb vacancies and improve carrier mobility, contributing to an unexpectedly high power factor of ~37 muW cm-1 K-2 at 423 K; Cu atoms filling Pb vacancies and Cu interstitials both induce local disorder and, together with nano- and microscale Cu-rich precipitates and their related strain fields, lead to a very low lattice thermal conductivity of ~0.38 Wm-1 K-1 in PbTe-5.5%Cu2Te, approaching the theoretical minimum value of ~0.36 Wm-1 K-1.	Copper	0-2	keratin 1	Homo sapiens	414-417
29460616-5	2018	Indeed, crystalline films with Seebeck coefficients of 624 and -78 muV K-1 are obtained for Sb2Te3 and Bi2Te3, respectively.	Antimony(III) telluride	92-98	keratin 1	Homo sapiens	71-74
29460616-5	2018	Indeed, crystalline films with Seebeck coefficients of 624 and -78 muV K-1 are obtained for Sb2Te3 and Bi2Te3, respectively.	Bi2Te3 Crystal	103-109	keratin 1	Homo sapiens	71-74
29359915-5	2018	The resulting Tb@UiO-66-Hybrid film exhibited good temperature-sensing properties with a relative sensitivity of up to 2.76% K-1 in the temperature range of 303-353 K. In addition, the Eu@UiO-66-Hybrid film showed excellent temperature-sensing performance based on the energy transfer between the luminescent ligand (H2NDC) and europium ions with a relative sensitivity of up to 4.26% K-1 in the temperature range of 303-403 K.	Terbium	14-16	keratin 1	Homo sapiens	125-128
29359915-5	2018	The resulting Tb@UiO-66-Hybrid film exhibited good temperature-sensing properties with a relative sensitivity of up to 2.76% K-1 in the temperature range of 303-353 K. In addition, the Eu@UiO-66-Hybrid film showed excellent temperature-sensing performance based on the energy transfer between the luminescent ligand (H2NDC) and europium ions with a relative sensitivity of up to 4.26% K-1 in the temperature range of 303-403 K.	Terbium	14-16	keratin 1	Homo sapiens	385-388
29336559-3	2018	Based on the new ratio as the temperature-sensing parameter, the Sa and Sr of the BaTiO3: 0.01%Pr3+, 8%Yb3+ nanoparticles at 313 K reach as high as 0.1380 K-1 and 1.23% K-1, respectively.	2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine	65-67	keratin 1	Homo sapiens	155-158
29336559-3	2018	Based on the new ratio as the temperature-sensing parameter, the Sa and Sr of the BaTiO3: 0.01%Pr3+, 8%Yb3+ nanoparticles at 313 K reach as high as 0.1380 K-1 and 1.23% K-1, respectively.	2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine	65-67	keratin 1	Homo sapiens	169-172
29336559-3	2018	Based on the new ratio as the temperature-sensing parameter, the Sa and Sr of the BaTiO3: 0.01%Pr3+, 8%Yb3+ nanoparticles at 313 K reach as high as 0.1380 K-1 and 1.23% K-1, respectively.	Strontium	72-74	keratin 1	Homo sapiens	155-158
29336559-3	2018	Based on the new ratio as the temperature-sensing parameter, the Sa and Sr of the BaTiO3: 0.01%Pr3+, 8%Yb3+ nanoparticles at 313 K reach as high as 0.1380 K-1 and 1.23% K-1, respectively.	Strontium	72-74	keratin 1	Homo sapiens	169-172
29336559-4	2018	Similarly, the Sa and Sr of the BaTiO3: 1%Er3+, 3%Yb3+ nanoparticles at 313 K are as high as 0.0413 K-1 and 1.05% K-1, respectively.	2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine	15-17	keratin 1	Homo sapiens	100-103
29336559-4	2018	Similarly, the Sa and Sr of the BaTiO3: 1%Er3+, 3%Yb3+ nanoparticles at 313 K are as high as 0.0413 K-1 and 1.05% K-1, respectively.	2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine	15-17	keratin 1	Homo sapiens	114-117
29336559-4	2018	Similarly, the Sa and Sr of the BaTiO3: 1%Er3+, 3%Yb3+ nanoparticles at 313 K are as high as 0.0413 K-1 and 1.05% K-1, respectively.	Strontium	22-24	keratin 1	Homo sapiens	100-103
29336559-4	2018	Similarly, the Sa and Sr of the BaTiO3: 1%Er3+, 3%Yb3+ nanoparticles at 313 K are as high as 0.0413 K-1 and 1.05% K-1, respectively.	Strontium	22-24	keratin 1	Homo sapiens	114-117
29337924-4	2018	The K1 and K2 in dry and wet atmospheres at 350  C were increased by humid aging at 580  C, indicating an increase in the adsorption amount of both O- and O2-.	Oxygen	155-157	keratin 1	Homo sapiens	4-13
29235852-6	2018	In particular, microdispersion of any combination of the LM and Cu additives results in a large number of interfaces and a thermal conductivity below 2 W m-1 K-1.	Copper	64-66	keratin 1	Homo sapiens	158-161
29235852-7	2018	In contrast, a shorter blending procedure of premixed LM and Cu particle colloid into the polymer matrix yields a composite with polydispersed filler and effective intrinsic thermal conductivities of up to 17 W m-1 K-1 (effective thermal conductivity of up to 10 W m-1 K-1).	Copper	61-63	keratin 1	Homo sapiens	215-218
29235852-7	2018	In contrast, a shorter blending procedure of premixed LM and Cu particle colloid into the polymer matrix yields a composite with polydispersed filler and effective intrinsic thermal conductivities of up to 17 W m-1 K-1 (effective thermal conductivity of up to 10 W m-1 K-1).	Copper	61-63	keratin 1	Homo sapiens	269-272
29235852-7	2018	In contrast, a shorter blending procedure of premixed LM and Cu particle colloid into the polymer matrix yields a composite with polydispersed filler and effective intrinsic thermal conductivities of up to 17 W m-1 K-1 (effective thermal conductivity of up to 10 W m-1 K-1).	Polymers	90-97	keratin 1	Homo sapiens	215-218
29235852-7	2018	In contrast, a shorter blending procedure of premixed LM and Cu particle colloid into the polymer matrix yields a composite with polydispersed filler and effective intrinsic thermal conductivities of up to 17 W m-1 K-1 (effective thermal conductivity of up to 10 W m-1 K-1).	Polymers	90-97	keratin 1	Homo sapiens	269-272
29278493-6	2018	In the tetragonal regime, the coefficients of volumetric thermal expansion of FASnI3 and FAPbBr3 are among the highest recorded for any extended inorganic crystalline solid, reaching 219 ppm K-1 for FASnI3 at 225 K. Atomic displacement parameters of all atoms for both materials suggest dynamic motion is occurring in the inorganic sublattice due to the flexibility of the inorganic network and dynamic lone pair stereochemical activity on the B-site.	fasni3	78-84	keratin 1	Homo sapiens	191-194
29182275-3	2017	Cu performs several outstanding roles: Cu atoms fill the Pb vacancies and improve carrier mobility, contributing to an unexpectedly high power factor of ~37 muW cm-1 K-2 at 423 K; Cu atoms filling Pb vacancies and Cu interstitials both induce local disorder and, together with nano- and microscale Cu-rich precipitates and their related strain fields, lead to a very low lattice thermal conductivity of ~0.38 Wm-1 K-1 in PbTe-5.5%Cu2Te, approaching the theoretical minimum value of ~0.36 Wm-1 K-1.	Copper	0-2	keratin 1	Homo sapiens	493-496
28700975-7	2017	Additionally, astilbin induced keratinocyte differentiation correlated with suppression of keratin 5 (KRT5) and KRT14 proteins (the markers of epidermal basal layer) and induction KRT1 and KRT10 proteins (occurring in the upper layers).	astilbin	14-22	keratin 1	Homo sapiens	112-116
28578242-3	2017	The values of PFO rate constant k1p and PSO rate constant k2p decreased as SMT-M3&gt;SMT-M3-plN2&gt;TC-M3-plN2&gt;TC-M3&gt;CP-M3&gt;CP-M3-plN2 and SMT-M3&gt;SMT-M3-plN2&gt;TC-M3&gt;TC-M3-plN2&gt;CP-M3&gt;CP-M3-plN2, respectively.	poly(9,9-di-n-octyl-2,7-fluorene)	14-17	keratin 1	Homo sapiens	32-35
29375980-6	2018	Applying a gate electric field to the MOS-HEMT simultaneously modulates S and sigma of the high-mobility electron gas from -490 microV K-1 and  10-1 S cm-1 to -90 microV K-1 and  104 S cm-1, while maintaining a high carrier mobility ( 1500 cm2 V-1 s-1).	mos-hemt	38-46	keratin 1	Homo sapiens	135-189
28735004-2	2017	Thermodynamic analysis DeltaH -14 to -10 (KJMol-1) and DeltaS 14 to -1 (JMol-1, K-1) showed tRNA-folic acid-chitosan bindings occur via H-bonding, hydrophobic and van der Waals contacts.	Folic Acid	97-107	keratin 1	Homo sapiens	80-83
29216153-4	2017	As a result, linearly temperature-sensitive fluorescence lifetime was achieved in the Cr3+-doped Bi2Ga4O9-Bi2Al4O9 SSs with a high Al/Ga ratio, enabling us to conveniently and accurately determine a temperature with a high relative sensitivity of 2.13-3.26%  K-1.	doped	91-96	keratin 1	Homo sapiens	259-262
29216153-4	2017	As a result, linearly temperature-sensitive fluorescence lifetime was achieved in the Cr3+-doped Bi2Ga4O9-Bi2Al4O9 SSs with a high Al/Ga ratio, enabling us to conveniently and accurately determine a temperature with a high relative sensitivity of 2.13-3.26%  K-1.	bi2ga4o9-bi2al4o9	97-114	keratin 1	Homo sapiens	259-262
29216153-4	2017	As a result, linearly temperature-sensitive fluorescence lifetime was achieved in the Cr3+-doped Bi2Ga4O9-Bi2Al4O9 SSs with a high Al/Ga ratio, enabling us to conveniently and accurately determine a temperature with a high relative sensitivity of 2.13-3.26%  K-1.	Aluminum	109-111	keratin 1	Homo sapiens	259-262
29216153-4	2017	As a result, linearly temperature-sensitive fluorescence lifetime was achieved in the Cr3+-doped Bi2Ga4O9-Bi2Al4O9 SSs with a high Al/Ga ratio, enabling us to conveniently and accurately determine a temperature with a high relative sensitivity of 2.13-3.26%  K-1.	Gallium	100-102	keratin 1	Homo sapiens	259-262
29075715-6	2017	The electrical and thermal conductivities of the as-prepared graphene paper were up to 2385 S cm-1 and 1324 W m-1 K-1, respectively, superior to those of most previously reported graphene materials.	Graphite	61-69	keratin 1	Homo sapiens	114-117
28602280-7	2017	The simulation plot of LOD with respect to K1 and alphaK2 showed that a K1 one order of magnitude lower than alphaK2 produced a ppt level LOD.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	128-131	keratin 1	Homo sapiens	43-57
28594118-3	2017	Notably, the presence of guest ions (K+ ) and molecules (H2 O) can substantially switch thermal expansion of YFe(CN)6 from negative (alphav =-33.67x10-6  K-1 ) to positive (alphav =+42.72x10-6  K-1 )-a range that covers the thermal expansion of most inorganic compounds.	Water	57-61	keratin 1	Homo sapiens	154-157
28773182-4	2017	In addition, the density of nano-PETT/PI/SG-CNT hybrid films decreased 1.31 to 0.85 g cm-3 with a decrease in thermal conductivity from 0.18 to 0.12 W m-1 K-1.	2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole	33-37	keratin 1	Homo sapiens	155-158
28594118-3	2017	Notably, the presence of guest ions (K+ ) and molecules (H2 O) can substantially switch thermal expansion of YFe(CN)6 from negative (alphav =-33.67x10-6  K-1 ) to positive (alphav =+42.72x10-6  K-1 )-a range that covers the thermal expansion of most inorganic compounds.	Water	57-61	keratin 1	Homo sapiens	194-197
28594118-3	2017	Notably, the presence of guest ions (K+ ) and molecules (H2 O) can substantially switch thermal expansion of YFe(CN)6 from negative (alphav =-33.67x10-6  K-1 ) to positive (alphav =+42.72x10-6  K-1 )-a range that covers the thermal expansion of most inorganic compounds.	SCHEMBL6233441	109-112	keratin 1	Homo sapiens	154-157
28594118-3	2017	Notably, the presence of guest ions (K+ ) and molecules (H2 O) can substantially switch thermal expansion of YFe(CN)6 from negative (alphav =-33.67x10-6  K-1 ) to positive (alphav =+42.72x10-6  K-1 )-a range that covers the thermal expansion of most inorganic compounds.	SCHEMBL6233441	109-112	keratin 1	Homo sapiens	194-197
28398431-2	2017	We have compared the thermoelectric properties of three zinc porphyrin (ZnP) dimers and a ZnP monomer and found that the "edge-over-edge" dimer formed from stacked ZnP rings possesses a high electrical conductance, negligible phonon thermal conductance and a high Seebeck coefficient of the order of 300 muV K-1.	zinc hematoporphyrin	72-75	keratin 1	Homo sapiens	308-311
27987371-5	2017	The overall in vitro result showed that combination of trans-chalcone, vitamin K1 and sorafenib (10, 5 and 5 muM concentration, respectively) enhanced the resistance against oxidative stress generated by H2 O2 .	Hydrogen Peroxide	204-209	keratin 1	Homo sapiens	79-108
28336935-4	2017	We present scanning transmission x-ray microscopy images at the Fe L3 and C K1 edges showing that the organic matter co-localized with Fe(III) consists primarily of C=C, C=O and C-OH functional groups.	ferric sulfate	135-142	keratin 1	Homo sapiens	74-78
28239697-3	2017	Using a Cr3+ to Nd3+ emission intensity ratio, the highest 3.48% K-1 sensitivity was obtained in the physiological temperature range.	nd3+	16-20	keratin 1	Homo sapiens	65-68
28193902-4	2017	By incorporating liquid metal (LM) microdroplets into a soft elastomer, we achieve a ~25x increase in thermal conductivity (4.7 +- 0.2 W m-1 K-1) over the base polymer (0.20 +- 0.01 W m-1 K-1) under stress-free conditions and a ~50x increase (9.8 +- 0.8 W m-1 K-1) when strained.	Metals	24-29	keratin 1	Homo sapiens	141-144
28193902-4	2017	By incorporating liquid metal (LM) microdroplets into a soft elastomer, we achieve a ~25x increase in thermal conductivity (4.7 +- 0.2 W m-1 K-1) over the base polymer (0.20 +- 0.01 W m-1 K-1) under stress-free conditions and a ~50x increase (9.8 +- 0.8 W m-1 K-1) when strained.	Metals	24-29	keratin 1	Homo sapiens	188-191
28193902-4	2017	By incorporating liquid metal (LM) microdroplets into a soft elastomer, we achieve a ~25x increase in thermal conductivity (4.7 +- 0.2 W m-1 K-1) over the base polymer (0.20 +- 0.01 W m-1 K-1) under stress-free conditions and a ~50x increase (9.8 +- 0.8 W m-1 K-1) when strained.	Metals	24-29	keratin 1	Homo sapiens	188-191
28193902-4	2017	By incorporating liquid metal (LM) microdroplets into a soft elastomer, we achieve a ~25x increase in thermal conductivity (4.7 +- 0.2 W m-1 K-1) over the base polymer (0.20 +- 0.01 W m-1 K-1) under stress-free conditions and a ~50x increase (9.8 +- 0.8 W m-1 K-1) when strained.	Leucylmethionine	31-33	keratin 1	Homo sapiens	141-144
28193902-4	2017	By incorporating liquid metal (LM) microdroplets into a soft elastomer, we achieve a ~25x increase in thermal conductivity (4.7 +- 0.2 W m-1 K-1) over the base polymer (0.20 +- 0.01 W m-1 K-1) under stress-free conditions and a ~50x increase (9.8 +- 0.8 W m-1 K-1) when strained.	Leucylmethionine	31-33	keratin 1	Homo sapiens	188-191
28193902-4	2017	By incorporating liquid metal (LM) microdroplets into a soft elastomer, we achieve a ~25x increase in thermal conductivity (4.7 +- 0.2 W m-1 K-1) over the base polymer (0.20 +- 0.01 W m-1 K-1) under stress-free conditions and a ~50x increase (9.8 +- 0.8 W m-1 K-1) when strained.	Leucylmethionine	31-33	keratin 1	Homo sapiens	188-191
29955705-1	2017	Background: The plant-based form of vitamin K (phylloquinone, vitamin K-1) has been well quantified in the US diet.	Vitamin K	36-45	keratin 1	Homo sapiens	70-73
28943996-3	2017	The GCM simulates basic state changes associated with increasing CO2 that are consistent with results from earlier studies: column water vapor increases at ~7.1% K-1, precipitation also increases but at a lower rate (~3% K-1), and column relative humidity shows little change.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	65-68	keratin 1	Homo sapiens	162-165
28943996-3	2017	The GCM simulates basic state changes associated with increasing CO2 that are consistent with results from earlier studies: column water vapor increases at ~7.1% K-1, precipitation also increases but at a lower rate (~3% K-1), and column relative humidity shows little change.	Water	131-136	keratin 1	Homo sapiens	162-165
28541928-4	2017	Besides, the variation of the luminescence intensity ratio of Tm3+ emissions as a function of temperature was monitored in the 77-293 K temperature range, and the maximum relative sensitivity (Sm) of the samples reached 1.33% K-1 for the hexagonal-plated nanoparticles and 1.76% K-1 for the spheroidal nanoparticles.	tm3+	62-66	keratin 1	Homo sapiens	226-229
28541928-4	2017	Besides, the variation of the luminescence intensity ratio of Tm3+ emissions as a function of temperature was monitored in the 77-293 K temperature range, and the maximum relative sensitivity (Sm) of the samples reached 1.33% K-1 for the hexagonal-plated nanoparticles and 1.76% K-1 for the spheroidal nanoparticles.	tm3+	62-66	keratin 1	Homo sapiens	279-282
28117979-3	2017	However, recent work suggested that kappa of micrometer-thick a-Si films can be greater than 3 W m-1 K-1, which is contributed to by propagating vibrational modes, referred to as "propagons".	Silicon	64-66	keratin 1	Homo sapiens	101-104
28117979-6	2017	We showed unexpectedly high kappa  in a-Si nanostructures, reaching ~3.0 and 5.3 W m-1 K-1 at ~100 nm and 1.7 mum, respectively.	Silicon	40-42	keratin 1	Homo sapiens	87-90
28139766-5	2017	For the mid-infrared, graphene-based detectors with TCRs ~4-11% K-1 have been demonstrated.	Graphite	22-30	keratin 1	Homo sapiens	64-67
28139766-7	2017	This is achieved by fabricating a floating metallic structure that concentrates the pyroelectric charge on the top-gate capacitor of the graphene channel, leading to TCRs up to 900% K-1, and the ability to resolve temperature variations down to 15 muK.	Graphite	137-145	keratin 1	Homo sapiens	182-185
27901022-4	2016	The all-graphene fabrics obtained through a wet-fusing assembly approach are porous and lightweight, showing high in-plane electrical conductivity up to ~2.8 x 104 S m-1 and prominent thermal conductivity of ~301.5 W m-1 K-1.	Graphite	8-16	keratin 1	Homo sapiens	221-224
28698808-2	2017	QUALITY OF EVIDENCE: PubMed was searched for articles on vitamin K (K1 and K2) along with books and conference proceedings and health conditions listed above.	Vitamin K	57-66	keratin 1	Homo sapiens	68-77
27805060-6	2016	The maximum relative sensor sensitivity using the rise time of Ho3+ energy level (5F4/5S2) is 1.35% K-1, which is the highest among the known sensitivities for luminescence based thermal probes.	ho3	63-66	keratin 1	Homo sapiens	100-103
27060689-4	2016	Phosphorylation of ERK, Akt and p38 MAPK, but not JNK, was increased by baicalein, and inhibition of phosphorylation of ERK, but not that of Akt or p38 MAPK, blocked the baicalein-induced increase in K1/K10 expression, suggesting that ERK activation is involved in this increase.	baicalein	72-81	keratin 1	Homo sapiens	200-206
26740170-12	2016	Moreover, protein analyses showed that CS decreased expression of keratin(K) 5 at 3, 6 and 9 d, and increased expression of K14 at 6 and 9 d. Finally, mRNA analyses showed significant decreases of K1, K6, K10 and K16 in CS-exposed cultures, correlating, at times, with a decrease of protein production.	Cesium	39-41	keratin 1	Homo sapiens	197-203
26740170-12	2016	Moreover, protein analyses showed that CS decreased expression of keratin(K) 5 at 3, 6 and 9 d, and increased expression of K14 at 6 and 9 d. Finally, mRNA analyses showed significant decreases of K1, K6, K10 and K16 in CS-exposed cultures, correlating, at times, with a decrease of protein production.	Cesium	220-222	keratin 1	Homo sapiens	197-203
27453822-9	2016	The K1, K10 transcript levels, SIRT1 protein and transcript levels in fructose treated psoriatic keratinocytes were improved.	Fructose	70-78	keratin 1	Homo sapiens	4-6
27060689-2	2016	Treatment of HaCaT keratinocytes with 10 mum baicalein slightly inhibited cell growth, caused morphological differentiation and increased expression of keratins 1 and 10 (K1/K10) without affecting ROS generation, cytochrome c release or apoptosis.	baicalein	45-54	keratin 1	Homo sapiens	152-169
27060689-2	2016	Treatment of HaCaT keratinocytes with 10 mum baicalein slightly inhibited cell growth, caused morphological differentiation and increased expression of keratins 1 and 10 (K1/K10) without affecting ROS generation, cytochrome c release or apoptosis.	baicalein	45-54	keratin 1	Homo sapiens	171-177
27664712-3	2016	expand the mutation spectrum for ichthyosis with confetti caused by mutations in KRT1, showing that a polyarginine frameshift in the keratin-1 tail can also cause this disorder.	polyarginine	102-114	keratin 1	Homo sapiens	81-85
27664712-3	2016	expand the mutation spectrum for ichthyosis with confetti caused by mutations in KRT1, showing that a polyarginine frameshift in the keratin-1 tail can also cause this disorder.	polyarginine	102-114	keratin 1	Homo sapiens	133-142
27980995-3	2016	Taking Ag8SnSe6 as an example, which shows one of the lowest sound velocities among known thermoelectric semiconductors, the lattice thermal conductivity is found to be as low as 0.2 W m-1 K-1 in the entire temperature range.	ag8snse6	7-15	keratin 1	Homo sapiens	189-192
25808222-4	2015	We analysed all exons and flanking sequences of the KRT1 and KRT10 genes using PCR, and found that the proband and his mother had a G&gt;C transition at nucleotide position 1432 in exon 7 of KRT1, resulting in an amino acid substitution of glutamate (GAA) to glutamine (CAA) at codon 478 (E478Q).	Glutamic Acid	240-249	keratin 1	Homo sapiens	52-56
26958637-4	2016	The MS/MS data were generated to confirm amino acid sequences and oxidation sites of tryptic peptides D(290)VDGAYMTK(298) (P1) and N(258)MQDMVEDYR(267) (P2), which contain the most susceptible oxidation sites (Met(259), Met(262), and Met(296) in K1 keratin) upon UVA irradiation [2].	Peptides	93-101	keratin 1	Homo sapiens	246-256
26351984-7	2015	hK1 amidase activity was estimated using the chromogenic substrate D-Val-Leu-Arg-Nan.	d-val-leu-arg-nan	67-84	keratin 1	Homo sapiens	0-3
26351984-9	2015	Urinary hK1-specific amidase activity was expressed as microM/(min   mg creatinine) to correct for differences in urine flow rates.	Creatinine	72-82	keratin 1	Homo sapiens	8-11
27000106-1	2016	PURPOSE: Functional vitamin K deficiency (both K1 and K2) is postulated to be one of the most relevant links between chronic kidney disease and vascular calcification in hemodialysis (HD) patients.	Vitamin K	20-29	keratin 1	Homo sapiens	47-56
26383628-7	2016	In normoxia and hypoxia, inhibition of miR-203 by transfection of NHEK with complementary oligonucleotides, anti-miR-203, attenuated the SM-induced impairment of metabolic activity and proliferation, and counteracted SM-promoted keratin-1 expression in these cells.	Oligonucleotides	90-106	keratin 1	Homo sapiens	229-238
26383628-8	2016	Consistent ameliorating effects on dysregulated metabolic activity, proliferation and keratin-1 expression in SM-treated NHEK were obtained upon inhibition of miR-210 in these cells grown in hypoxia.	Mustard Gas	110-112	keratin 1	Homo sapiens	86-95
26646290-6	2016	We also found that N-acetyl-l-cysteine (NAC), a reactive oxygen species scavenger, antagonized the hypoxia-induced reduction of K1/K10 in keratinocytes and SEs.	Reactive Oxygen Species	48-71	keratin 1	Homo sapiens	128-134
25808222-4	2015	We analysed all exons and flanking sequences of the KRT1 and KRT10 genes using PCR, and found that the proband and his mother had a G&gt;C transition at nucleotide position 1432 in exon 7 of KRT1, resulting in an amino acid substitution of glutamate (GAA) to glutamine (CAA) at codon 478 (E478Q).	Glutamic Acid	240-249	keratin 1	Homo sapiens	61-65
25808222-4	2015	We analysed all exons and flanking sequences of the KRT1 and KRT10 genes using PCR, and found that the proband and his mother had a G&gt;C transition at nucleotide position 1432 in exon 7 of KRT1, resulting in an amino acid substitution of glutamate (GAA) to glutamine (CAA) at codon 478 (E478Q).	Glutamine	259-268	keratin 1	Homo sapiens	52-56
25808222-4	2015	We analysed all exons and flanking sequences of the KRT1 and KRT10 genes using PCR, and found that the proband and his mother had a G&gt;C transition at nucleotide position 1432 in exon 7 of KRT1, resulting in an amino acid substitution of glutamate (GAA) to glutamine (CAA) at codon 478 (E478Q).	Glutamine	259-268	keratin 1	Homo sapiens	61-65
26119310-4	2015	Some intervention studies have described that vitamin K1 and vitamin K2 (menaquinone-4 : MK-4) supplementation were modestly efficacious in preventing fracture, but not in preserving bone mass.	menatetrenone	89-93	keratin 1	Homo sapiens	54-86
25605727-7	2015	During Golgi recovery after brefeldin A treatment, C2GnT-M forms a complex with Giantin before KRT1, demonstrating CT-mediated sequential events of Golgi targeting and retention of C2GnT-M.	ct	115-117	keratin 1	Homo sapiens	95-99
25144715-0	2014	Inhibitory effect of 2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo(b)pyran (K-1) on human primary endometrial hyperplasial cells mediated via combined suppression of Wnt/beta-catenin signaling and PI3K/Akt survival pathway.	2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo(b)pyran	21-84	keratin 1	Homo sapiens	86-89
25825023-0	2015	Docosahexaenoic acid inhibits the invasion of MDA-MB-231 breast cancer cells through upregulation of cytokeratin-1.	Docosahexaenoic Acids	0-20	keratin 1	Homo sapiens	101-114
25825023-5	2015	Immunocytochemistry analyses confirmed the increase in KRT1 induced by DHA.	Docosahexaenoic Acids	71-74	keratin 1	Homo sapiens	55-59
25825023-6	2015	Furthermore, in vitro invasion assays showed that siRNA against KRT1 was able to reverse the DHA-induced inhibition of breast cancer cell invasion.	Docosahexaenoic Acids	93-96	keratin 1	Homo sapiens	64-68
25825023-7	2015	In conclusion, KRT1 is involved in the anti-invasive activity of DHA in breast cancer cells.	Docosahexaenoic Acids	65-68	keratin 1	Homo sapiens	15-19
25144715-3	2014	The benzopyran compound 2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo (b) pyran(K-1), a potent antiestrogenic agent, has been shown to have apoptosis-inducing activity in rat uterine hyperplasia.	Benzopyrans	4-14	keratin 1	Homo sapiens	90-93
25144715-3	2014	The benzopyran compound 2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo (b) pyran(K-1), a potent antiestrogenic agent, has been shown to have apoptosis-inducing activity in rat uterine hyperplasia.	2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo(b)pyran	24-89	keratin 1	Homo sapiens	90-93
23157658-6	2013	RESULTS: The addition of histamine to human keratinocyte cultures and organotypic skin models reduced the expression of the differentiation-associated proteins keratin 1/10, filaggrin, and loricrin by 80-95%.	Histamine	25-34	keratin 1	Homo sapiens	160-169
24816681-1	2014	The CYP4F subfamily of enzymes has been identified recently to be involved in the metabolism of endogenous compounds (arachidonic acid and leukotriene B4), nutrients (vitamins K1 and E), and xenobiotics (pafuramidine and fingolimod).	Arachidonic Acid	118-134	keratin 1	Homo sapiens	176-184
24816681-1	2014	The CYP4F subfamily of enzymes has been identified recently to be involved in the metabolism of endogenous compounds (arachidonic acid and leukotriene B4), nutrients (vitamins K1 and E), and xenobiotics (pafuramidine and fingolimod).	Leukotriene B4	139-153	keratin 1	Homo sapiens	176-184
24816681-1	2014	The CYP4F subfamily of enzymes has been identified recently to be involved in the metabolism of endogenous compounds (arachidonic acid and leukotriene B4), nutrients (vitamins K1 and E), and xenobiotics (pafuramidine and fingolimod).	Fingolimod Hydrochloride	221-231	keratin 1	Homo sapiens	176-184
24280725-6	2014	The restoration of the downregulated expression levels of Krt1 and Krt10 induced by IL-4 with the MEK (mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase kinase) inhibitor U0126 indicated the involvement of the p44/42 MAPK signaling pathway in the attenuated expression.	U 0126	199-204	keratin 1	Homo sapiens	58-62
24569995-5	2014	Active centers lie between K1 and L2 or K2 and L1: dihydroxyacetone binds K and ATP binds L in different subunits too distant (  14 A) for phosphoryl transfer.	Dihydroxyacetone	51-67	keratin 1	Homo sapiens	27-49
24569995-5	2014	Active centers lie between K1 and L2 or K2 and L1: dihydroxyacetone binds K and ATP binds L in different subunits too distant (  14 A) for phosphoryl transfer.	Adenosine Triphosphate	80-83	keratin 1	Homo sapiens	27-49
24332816-7	2014	In addition, DPI, an inhibitor of NOXes, significantly reversed the ionomycin-induced H2O2 level, and inhibited the mRNA expression levels of keratin 1, keratin 10, and filaggrin compared with other ROS generating system inhibitors.	3-aminodiphenyleneiodium	13-16	keratin 1	Homo sapiens	142-151
23402905-1	2013	OBJECTIVE: The aim of the present study was to investigate the effect of non-steroidal, pure antiestrogenic benzopyran derivative i.e., 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b)pyran (K-1) on the growth of human endometrial cancer cells in vivo and in vitro and to elucidate its mechanism of action.	Benzopyrans	108-118	keratin 1	Homo sapiens	201-204
23402905-1	2013	OBJECTIVE: The aim of the present study was to investigate the effect of non-steroidal, pure antiestrogenic benzopyran derivative i.e., 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b)pyran (K-1) on the growth of human endometrial cancer cells in vivo and in vitro and to elucidate its mechanism of action.	2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo(b)pyran	136-199	keratin 1	Homo sapiens	201-204
22348822-8	2012	Taken together, KRT1 protein and its activity levels were higher in cDDP-resistant NPC cell lines compared to their parental cell lines.	Cisplatin	68-72	keratin 1	Homo sapiens	16-20
23210831-5	2013	K1/K2 in DMSO (1.3 x 10(7)) was significantly larger than the value in water (2 x 10).	Dimethyl Sulfoxide	9-13	keratin 1	Homo sapiens	0-5
23210831-6	2013	In addition, K1/K(E) = 200 (where K(E) is the acidity constant of the monomethylester of 1) was greater than the intramolecular hydrogen bonding threshold value of 2.	Hydrogen	128-136	keratin 1	Homo sapiens	13-26
22716220-4	2012	The results in water, especially the activation entropy (+14 +- 2 J K(-1) mol(-1)) and activation volume (-5.9 +- 0.6 cm(3) mol(-1)), differ significantly from those found for the other solvents.	Water	15-20	keratin 1	Homo sapiens	68-73
23650580-0	2012	The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes.	Calcium	37-44	keratin 1	Homo sapiens	53-66
22297637-3	2012	At micromolar concentrations, DHICA induced: (a) time- and dose-dependent reduction of cell proliferation without concomitant toxicity; (b) enhanced expression of early (spinous keratins K1 and K10 and envelope protein involucrin) and late (loricrin and filaggrin) differentiation markers; (c) increased activities and expression of antioxidant enzymes; and (d) decreased cell damage and apoptosis following UVA exposure.	5,6-dihydroxy-2-indolylcarboxylic acid	30-35	keratin 1	Homo sapiens	187-229
22429403-3	2012	RESULTS: The observation that the malate-OAA shuttle activity and the AOX pathway capacity increased markedly after intense light treatment in Rumex K-1 leaves indicates that excess NADPH was transported from the chloroplasts and oxidised by the AOX pathway.	NADP	182-187	keratin 1	Homo sapiens	149-152
21068754-5	2011	Although linoleic acid did not directly affect keratinocyte differentiation, keratin 1 expression was induced by the linoleic acid derivative 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE), and this induction was concomitant with increased NF-kappaB activity.	13-hydroxy-9,11-octadecadienoic acid	142-175	keratin 1	Homo sapiens	77-86
25214340-4	2011	Our results indicated that the larger value of the ratio of two equilibrium constant K1/K2, the more effectively lactisole inhibited the sweetness of the sweetener.	lactisole	113-122	keratin 1	Homo sapiens	85-90
22608582-14	2012	Moreover, the dose of propofol for induction in Group K5 was smaller than in Group S, Group K1, and Group K3 (P &lt; 0.05).	Propofol	22-30	keratin 1	Homo sapiens	92-108
21883255-0	2011	Mitochondrial alternative oxidase pathway protects plants against photoinhibition by alleviating inhibition of the repair of photodamaged PSII through preventing formation of reactive oxygen species in Rumex K-1 leaves.	Reactive Oxygen Species	175-198	keratin 1	Homo sapiens	208-211
22063565-2	2011	Such a case takes place if the relation C(0)=C+C(2) x 10(pK(1)) is valid, where pK(1)=-log K(1), K(1) - dissociation constant for a weak monoprotic acid HL.	monoprotic acid	137-152	keratin 1	Homo sapiens	58-62
22063565-2	2011	Such a case takes place if the relation C(0)=C+C(2) x 10(pK(1)) is valid, where pK(1)=-log K(1), K(1) - dissociation constant for a weak monoprotic acid HL.	monoprotic acid	137-152	keratin 1	Homo sapiens	81-85
21380727-5	2011	In the presence of NAD(+), the complex of keratin 1 and lectin was dissociated, what was recorded during elution of its separate components out of affinity columns and by decrease of their apparent molecular masses during gel-filtration.	NAD	19-25	keratin 1	Homo sapiens	42-51
21380727-7	2011	The latter effect was observed using mannose-binding lectin out of human serum, which is free from keratin 1.	Mannose	37-44	keratin 1	Homo sapiens	99-108
21303657-9	2011	hK1 amidase activity was estimated with D-Val-Leu-Arg-Nan substrate.	d-val-leu-arg	40-53	keratin 1	Homo sapiens	0-3
21303657-11	2011	hK1 specific amidase activity was expressed as muM/(minmg creatinine) to correct for differences in urine flow rate.	Creatinine	58-68	keratin 1	Homo sapiens	0-3
21068754-5	2011	Although linoleic acid did not directly affect keratinocyte differentiation, keratin 1 expression was induced by the linoleic acid derivative 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE), and this induction was concomitant with increased NF-kappaB activity.	Linoleic Acid	9-22	keratin 1	Homo sapiens	77-86
21068754-5	2011	Although linoleic acid did not directly affect keratinocyte differentiation, keratin 1 expression was induced by the linoleic acid derivative 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE), and this induction was concomitant with increased NF-kappaB activity.	Linoleic Acid	117-130	keratin 1	Homo sapiens	77-86
21068754-5	2011	Although linoleic acid did not directly affect keratinocyte differentiation, keratin 1 expression was induced by the linoleic acid derivative 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE), and this induction was concomitant with increased NF-kappaB activity.	13-hydroxy-9,11-octadecadienoic acid	177-187	keratin 1	Homo sapiens	77-86
21068754-7	2011	The reduction of linoleic acid in E-FABP(-/-) keratinocytes led to decreased cellular 13(S)-HODE content, resulting in decreased keratin 1 expression through downregulation of NF-kappaB activity.	Linoleic Acid	17-30	keratin 1	Homo sapiens	129-138
20713726-2	2010	Flecainide, a widely used antiarrhythmic drug, exhibits ventricular proarrhythmic effects while effectively controlling ventricular arrhythmias associated with mutations in the gene encoding Kir2.1 channels that decrease I(K1) (Andersen syndrome).	Flecainide	0-10	keratin 1	Homo sapiens	212-226
21210061-6	2011	Using UV-vis and high-resolution two-dimensional (2D) NMR spectroscopy, the bifunctionality of K1 and K2 (metal chelation and Abeta interaction) was confirmed.	Metals	106-111	keratin 1	Homo sapiens	95-104
21270730-1	2011	Logarithms of stability constants, log K1 and log beta2, of the first transition series metal mono- and bis-complexes with any of four aliphatic amino acids (glycine, alanine, valine and leucine) decrease monotonously with third order valence connectivity index, 3chiv, from Cu2+ to Mn2+.	Metals	88-93	keratin 1	Homo sapiens	39-55
21270730-1	2011	Logarithms of stability constants, log K1 and log beta2, of the first transition series metal mono- and bis-complexes with any of four aliphatic amino acids (glycine, alanine, valine and leucine) decrease monotonously with third order valence connectivity index, 3chiv, from Cu2+ to Mn2+.	cupric ion	275-279	keratin 1	Homo sapiens	39-55
21270730-1	2011	Logarithms of stability constants, log K1 and log beta2, of the first transition series metal mono- and bis-complexes with any of four aliphatic amino acids (glycine, alanine, valine and leucine) decrease monotonously with third order valence connectivity index, 3chiv, from Cu2+ to Mn2+.	Manganese(2+)	283-287	keratin 1	Homo sapiens	39-55
21270730-5	2011	= 0.11), for log K1 and log beta2, respectively, were developed only for Mn2+, Fe2+, Co2+, and Ni2+ complexes with amino acids.	Manganese(2+)	73-77	keratin 1	Homo sapiens	17-33
21270730-5	2011	= 0.11), for log K1 and log beta2, respectively, were developed only for Mn2+, Fe2+, Co2+, and Ni2+ complexes with amino acids.	ammonium ferrous sulfate	79-83	keratin 1	Homo sapiens	17-33
21270730-5	2011	= 0.11), for log K1 and log beta2, respectively, were developed only for Mn2+, Fe2+, Co2+, and Ni2+ complexes with amino acids.	Cobalt(2+)	85-89	keratin 1	Homo sapiens	17-33
21270730-5	2011	= 0.11), for log K1 and log beta2, respectively, were developed only for Mn2+, Fe2+, Co2+, and Ni2+ complexes with amino acids.	Nickel(2+)	95-99	keratin 1	Homo sapiens	17-33
20346212-8	2010	RESULTS: The research showed that K1 and FTC-133 cells had cell spacing increases, with an outer edge of smooth, nuclear chromatin condensation after RA combined TSA.	Tretinoin	150-152	keratin 1	Homo sapiens	34-48
20030669-4	2010	In human embryonic kidney (HEK)293 cells, vitamin K3 inhibited the tumour necrosis factor (TNF)-alpha-evoked translocation of nuclear factor (NF)-kappaB into the nucleus, although vitamins K1 and K2 did not.	Vitamin K 3	42-52	keratin 1	Homo sapiens	189-198
20346212-8	2010	RESULTS: The research showed that K1 and FTC-133 cells had cell spacing increases, with an outer edge of smooth, nuclear chromatin condensation after RA combined TSA.	trichostatin A	162-165	keratin 1	Homo sapiens	34-48
20346212-14	2010	CONCLUSIONS: Lower concentrations of RA combined with lower concentrations of TSA have both inhibited cell proliferation, decreased toxicity of the drugs, and increased the effect of K1 and FTC-133 cell differentiation.	Tretinoin	37-39	keratin 1	Homo sapiens	183-197
20346212-14	2010	CONCLUSIONS: Lower concentrations of RA combined with lower concentrations of TSA have both inhibited cell proliferation, decreased toxicity of the drugs, and increased the effect of K1 and FTC-133 cell differentiation.	trichostatin A	78-81	keratin 1	Homo sapiens	183-197
19441036-4	2009	Stability constants beta1, beta2 and beta3 have been obtained at 25 +/- 1 degrees C at a constant ionic strength of 0.37 M in NaClO4 for K1 and NaCl for beta2 and beta3.	sodium perchlorate	126-132	keratin 1	Homo sapiens	137-148
20217174-3	2010	The derivative technique also revealed for the first time a substantial increase in glassy-state expansivity with increasing nBMA content in S/nBMA random copolymers, from 1.4x10(-4) K-1 in PS to 3.5x10(-4) K-1 in PnBMA.	butyl methacrylate	125-129	keratin 1	Homo sapiens	183-186
20217174-3	2010	The derivative technique also revealed for the first time a substantial increase in glassy-state expansivity with increasing nBMA content in S/nBMA random copolymers, from 1.4x10(-4) K-1 in PS to 3.5x10(-4) K-1 in PnBMA.	butyl methacrylate	125-129	keratin 1	Homo sapiens	207-210
20217174-3	2010	The derivative technique also revealed for the first time a substantial increase in glassy-state expansivity with increasing nBMA content in S/nBMA random copolymers, from 1.4x10(-4) K-1 in PS to 3.5x10(-4) K-1 in PnBMA.	copolymers	155-165	keratin 1	Homo sapiens	183-186
20217174-3	2010	The derivative technique also revealed for the first time a substantial increase in glassy-state expansivity with increasing nBMA content in S/nBMA random copolymers, from 1.4x10(-4) K-1 in PS to 3.5x10(-4) K-1 in PnBMA.	Phosphorus	190-192	keratin 1	Homo sapiens	183-186
19769007-8	2009	hK1 amidase activity is expressed in microM/(min x mg creatinine) to correct for differences in urine flow rate.	Creatinine	54-64	keratin 1	Homo sapiens	0-3
19608980-2	2009	OBJECTIVE: This study aims to analyze the effects of nitric oxide (NO) on human atrial I(K1) and on Kir2.1 channels, the major isoform of inwardly rectifying channels present in the human heart.	Nitric Oxide	53-65	keratin 1	Homo sapiens	80-92
18849344-5	2008	In contrast, DeltaNp63alpha induced keratin 1 (K1), which is expressed at the start of differentiation, via c-Jun N-terminal kinase (JNK)/AP-1 activation.	deltanp63alpha	13-27	keratin 1	Homo sapiens	36-45
19392295-3	2009	Computed results show excellent agreement with experimental data for a wide diameter and temperature range (25-350 K), and successfully predict the extraordinarily low thermal conductivity of 2 W m(-1) K-1 at room temperature in rough-etched 50 nm silicon nanowires.	Silicon	248-255	keratin 1	Homo sapiens	202-205
18849344-5	2008	In contrast, DeltaNp63alpha induced keratin 1 (K1), which is expressed at the start of differentiation, via c-Jun N-terminal kinase (JNK)/AP-1 activation.	deltanp63alpha	13-27	keratin 1	Homo sapiens	47-49
18340000-1	2008	Human tissue kallikrein (hK1) plays an important role in regulation of blood pressure, electrolyte and glucose transport, and renal function.	Glucose	103-110	keratin 1	Homo sapiens	25-28
19123346-4	2008	Under the stress of 300 mmol KCl x L(-1), the leaf Na+ concentration decreased by 88.6%, compared with the control, while the supplement of 25 mmol NaCl x L(-1) could obviously alleviate the damage of KCl on leaf photosynthesis, which proved that the deficit of Na+ and the accumulation of K+ in Rumex K-1 leaves could be responsible to the enhanced damage caused by 300 mmol x L(-1) of KCl.	Potassium Chloride	29-32	keratin 1	Homo sapiens	302-305
19123346-4	2008	Under the stress of 300 mmol KCl x L(-1), the leaf Na+ concentration decreased by 88.6%, compared with the control, while the supplement of 25 mmol NaCl x L(-1) could obviously alleviate the damage of KCl on leaf photosynthesis, which proved that the deficit of Na+ and the accumulation of K+ in Rumex K-1 leaves could be responsible to the enhanced damage caused by 300 mmol x L(-1) of KCl.	Sodium Chloride	148-152	keratin 1	Homo sapiens	302-305
19123346-4	2008	Under the stress of 300 mmol KCl x L(-1), the leaf Na+ concentration decreased by 88.6%, compared with the control, while the supplement of 25 mmol NaCl x L(-1) could obviously alleviate the damage of KCl on leaf photosynthesis, which proved that the deficit of Na+ and the accumulation of K+ in Rumex K-1 leaves could be responsible to the enhanced damage caused by 300 mmol x L(-1) of KCl.	Potassium Chloride	201-204	keratin 1	Homo sapiens	302-305
19123346-4	2008	Under the stress of 300 mmol KCl x L(-1), the leaf Na+ concentration decreased by 88.6%, compared with the control, while the supplement of 25 mmol NaCl x L(-1) could obviously alleviate the damage of KCl on leaf photosynthesis, which proved that the deficit of Na+ and the accumulation of K+ in Rumex K-1 leaves could be responsible to the enhanced damage caused by 300 mmol x L(-1) of KCl.	Potassium Chloride	201-204	keratin 1	Homo sapiens	302-305
18361511-3	2008	The sulfhydryl groups of cysteines in the head region of the keratin proteins 1 (K1) and 10 (K10) are likely targets.	Cysteine	25-34	keratin 1	Homo sapiens	61-91
18636694-3	2008	An Arrhenius expression for this reaction was determined to be k 1 (II)( T) = (7.23 +/- 1.2) x10 (-11)exp[(664 +/- 49)/ T] cm (3) molecule (-1) s (-1) at 263-423 K. The reaction was found to be independent of pressure between 1 and 6 Torr and over the temperature range of 262- 423 K, in contrast to previous results for the OH + isoprene reaction under similar conditions.	oh + isoprene	325-338	keratin 1	Homo sapiens	63-66
18065489-1	2007	Vitamin K3 (menadione; 2-methyl-1,4-naphthoquinone) is a structural precursor of vitamins K1 and K2, which are essential for blood clotting.	Vitamin K 3	0-10	keratin 1	Homo sapiens	90-99
18245893-5	2008	The new biological functions of vitamin K in bone are considered to be attributable, at least in part, to promotion of gamma-carboxylation of glutamic acid residues in vitamin K-dependent proteins, which is shared by both vitamins K1 and K2.	Vitamin K	32-41	keratin 1	Homo sapiens	231-240
18245893-5	2008	The new biological functions of vitamin K in bone are considered to be attributable, at least in part, to promotion of gamma-carboxylation of glutamic acid residues in vitamin K-dependent proteins, which is shared by both vitamins K1 and K2.	Glutamic Acid	142-155	keratin 1	Homo sapiens	231-240
18065489-1	2007	Vitamin K3 (menadione; 2-methyl-1,4-naphthoquinone) is a structural precursor of vitamins K1 and K2, which are essential for blood clotting.	Vitamin K 3	12-21	keratin 1	Homo sapiens	90-99
18065489-1	2007	Vitamin K3 (menadione; 2-methyl-1,4-naphthoquinone) is a structural precursor of vitamins K1 and K2, which are essential for blood clotting.	Vitamin K 3	23-50	keratin 1	Homo sapiens	90-99
17451983-0	2007	Modeling of alphak/gamma2 (k=1, 2, 3 and 5) interface of GABA A receptor and docking studies with zolpidem: implications for selectivity.	Zolpidem	98-106	keratin 1	Homo sapiens	12-42
18374191-16	2008	Future studies are also required to identify the enzymes that catalyze high affinity reduction of vitamin K1 and K2 to hydroquinone for use in gamma-carboxylation reactions.	hydroquinone	119-131	keratin 1	Homo sapiens	106-115
17960045-0	2007	[Effects of different nitrogen application rate on allocation of photosynthetic electron flux in Rumex K-1 leaves].	Nitrogen	22-30	keratin 1	Homo sapiens	103-106
17045186-8	2006	hK1 amidase activity was estimated with D-Val-Leu-Arg-Nan substrate.	d-val-leu-arg	40-53	keratin 1	Homo sapiens	0-3
17339076-5	2007	Always k(1) follows the order: k(1)(CIO)(4) &gt;/= k(1)(NO3)(4) &gt;&gt; k(1)(Cl).	punky blue	56-59	keratin 1	Homo sapiens	7-11
17339076-5	2007	Always k(1) follows the order: k(1)(CIO)(4) &gt;/= k(1)(NO3)(4) &gt;&gt; k(1)(Cl).	punky blue	56-59	keratin 1	Homo sapiens	31-35
17339076-5	2007	Always k(1) follows the order: k(1)(CIO)(4) &gt;/= k(1)(NO3)(4) &gt;&gt; k(1)(Cl).	punky blue	56-59	keratin 1	Homo sapiens	31-35
17339076-5	2007	Always k(1) follows the order: k(1)(CIO)(4) &gt;/= k(1)(NO3)(4) &gt;&gt; k(1)(Cl).	punky blue	56-59	keratin 1	Homo sapiens	31-35
17677502-5	2007	The ratio k1/k0 is an indication of the extent of cooperativity of binding adjacent segments on the polymer.	Polymers	100-107	keratin 1	Homo sapiens	10-15
17677502-6	2007	We observe that c(0,t), c(1,t), and c(2,t) decay to 0 (no correlation) more slowly and the maximum values of c(1,t) and c(2,t) are lower for low values of k1/k0 as compared to high values of k1/k0.	Carbon	16-17	keratin 1	Homo sapiens	155-160
17677502-6	2007	We observe that c(0,t), c(1,t), and c(2,t) decay to 0 (no correlation) more slowly and the maximum values of c(1,t) and c(2,t) are lower for low values of k1/k0 as compared to high values of k1/k0.	Carbon	16-17	keratin 1	Homo sapiens	191-196
17677502-7	2007	This is because at low values of k1/k0 the consecutive binding of adjacent segments along the polymer occurs slowly, while at high values of k1/k0 the cooperativity of binding adjacent segments is high and the segments along the polymer bind in a fast zipping mechanism.	Polymers	94-101	keratin 1	Homo sapiens	33-38
17677502-7	2007	This is because at low values of k1/k0 the consecutive binding of adjacent segments along the polymer occurs slowly, while at high values of k1/k0 the cooperativity of binding adjacent segments is high and the segments along the polymer bind in a fast zipping mechanism.	Polymers	229-236	keratin 1	Homo sapiens	33-38
17677502-7	2007	This is because at low values of k1/k0 the consecutive binding of adjacent segments along the polymer occurs slowly, while at high values of k1/k0 the cooperativity of binding adjacent segments is high and the segments along the polymer bind in a fast zipping mechanism.	Polymers	229-236	keratin 1	Homo sapiens	141-146
17124179-2	2007	Gamma-carboxylation of vitamin K-dependent proteins is dependent on formation of reduced vitamin K1 (Vit.K1H2) in the endoplasmic reticulum (ER), where it works as an essential cofactor for gamma-carboxylase in post-translational gamma-carboxylation of vitamin K-dependent proteins.	Vitamin K	23-32	keratin 1	Homo sapiens	97-99
17124179-3	2007	Vit.K1H2 is produced by the warfarin-sensitive enzyme vitamin K 2,3-epoxide reductase (VKOR) of the vitamin K cycle that has been shown to harbor a thioredoxin-like CXXC center involved in reduction of vitamin K1 2,3-epoxide (Vit.K&gt;O).	Warfarin	28-36	keratin 1	Homo sapiens	0-8
17124179-3	2007	Vit.K1H2 is produced by the warfarin-sensitive enzyme vitamin K 2,3-epoxide reductase (VKOR) of the vitamin K cycle that has been shown to harbor a thioredoxin-like CXXC center involved in reduction of vitamin K1 2,3-epoxide (Vit.K&gt;O).	Vitamin K	54-63	keratin 1	Homo sapiens	0-8
17124179-3	2007	Vit.K1H2 is produced by the warfarin-sensitive enzyme vitamin K 2,3-epoxide reductase (VKOR) of the vitamin K cycle that has been shown to harbor a thioredoxin-like CXXC center involved in reduction of vitamin K1 2,3-epoxide (Vit.K&gt;O).	vitamin K1 oxide	202-224	keratin 1	Homo sapiens	0-8
17455917-6	2007	For (7)LiD2+, rovibrational transition frequencies for K = 0, 1, 2 and J &lt; or = 10 are within ca.	lid2+	7-12	keratin 1	Homo sapiens	55-72
17297992-3	2007	Decreasing distances of 11and 8 mum revealed cytoplasmic extension of the early differentiation marker K1 on poly(dimethylsiloxane) (PDMS) pillars.	baysilon	109-131	keratin 1	Homo sapiens	103-105
16815498-7	2006	Most of the new biological functions of vitamin K in bone, vasculature, and hepatoma cells are considered attributable to promotion of gamma-carboxylation of glutamic acid residues in vitamin K-dependent proteins, which is shared by vitamins K1 and K2.	Vitamin K	40-49	keratin 1	Homo sapiens	242-251
16830865-1	2006	Human tissue kallikrein (hK1) plays an important role in regulation of blood pressure, electrolyte and glucose transport, and renal function.	Glucose	103-110	keratin 1	Homo sapiens	25-28
16776504-3	2006	In acidic solution (HCl) and at intermediate pH values (acetate buffers), water attack (k1(H2O) is rate limiting for 8-Me, 8-Et, and 8-s-Bu; the same is presumably the case for 8-t-Bu, but rates were too slow for accurate measurements at low pH.	Hydrochloric Acid	20-23	keratin 1	Homo sapiens	88-94
16776504-3	2006	In acidic solution (HCl) and at intermediate pH values (acetate buffers), water attack (k1(H2O) is rate limiting for 8-Me, 8-Et, and 8-s-Bu; the same is presumably the case for 8-t-Bu, but rates were too slow for accurate measurements at low pH.	Acetates	56-63	keratin 1	Homo sapiens	88-94
16776504-3	2006	In acidic solution (HCl) and at intermediate pH values (acetate buffers), water attack (k1(H2O) is rate limiting for 8-Me, 8-Et, and 8-s-Bu; the same is presumably the case for 8-t-Bu, but rates were too slow for accurate measurements at low pH.	Water	74-79	keratin 1	Homo sapiens	88-94
16776504-3	2006	In acidic solution (HCl) and at intermediate pH values (acetate buffers), water attack (k1(H2O) is rate limiting for 8-Me, 8-Et, and 8-s-Bu; the same is presumably the case for 8-t-Bu, but rates were too slow for accurate measurements at low pH.	8-me	117-121	keratin 1	Homo sapiens	88-94
17045186-10	2006	hK1 amidase activity was expressed in muM.min(-1).mL(-1) urine and in muM.min(-1).mg(-1) creatinine to correct for differences in urine flow rate.	Creatinine	89-99	keratin 1	Homo sapiens	0-3
16375341-2	2005	The first and second association constants, K1 and K2, for ion pair formation in aqueous 0.02-3.5 M solutions of bis(trimethyl)-alpha,omega-alkanediammonium halides with variable spacer lengths, 1-n-1 2X (n = 2-4, X = Cl, Br) and bolaform salts and for tetramethylammonium halides (TMAX, X = Cl, Br), K(TMAX), were determined by the chemical trapping method.	bis(trimethyl)-alpha,omega-alkanediammonium halides	113-164	keratin 1	Homo sapiens	44-53
16813168-6	2006	We have shown that adsorption of the first two PGEk molecules on TMO and TMS occurs noncooperatively with the high association constants K1(TMO) = (7 +/- 1) x 10(7) M(-1) and K1(TMS) = (3 +/- 0.5) x 10(7) M(-1), respectively.	pgek	47-51	keratin 1	Homo sapiens	175-187
16537612-2	2006	K1 is a transmembrane glycoprotein having a functional immunoreceptor tyrosine-based activation motif (ITAM) capable of activating B-cell receptor signaling.	Tyrosine	70-78	keratin 1	Homo sapiens	0-2
16838068-7	2006	Epidermal differentiation marker proteins such as involucrin, loricrin, and keratin1 were also increased in PS-treated NHEKs, by ELISA or Western blotting analysis.	phytosphingosine	108-110	keratin 1	Homo sapiens	76-84
16361731-5	2005	We found in this case a novel mutation, 559C to T, at amino acid position 187, which resulted in a leucine to phenylalanine substitution within the helix initiation motif of K1.	Leucine	99-106	keratin 1	Homo sapiens	174-176
16361731-5	2005	We found in this case a novel mutation, 559C to T, at amino acid position 187, which resulted in a leucine to phenylalanine substitution within the helix initiation motif of K1.	Phenylalanine	110-123	keratin 1	Homo sapiens	174-176
16161584-2	2005	The hydrogen interchange tunneling is basically quenched in (4, 0) for both K = 0 and 1 levels, consistent with the early suggestion from a phenomenological model [H.-C. Chang and W. Klemperer, J. Chem.	Hydrogen	4-12	keratin 1	Homo sapiens	76-87
15872348-12	2005	CONCLUSION: The high uptake of (68)Ga-DOTA-TOC in meningiomas can be explained by the high values for vB and by the remarkably low values for k2 and k4, leading to significantly greater k1/k2 and k3/k4 ratios and RB in meningiomas than in reference tissue.	ga-dota	35-42	keratin 1	Homo sapiens	186-191
15888189-0	2005	A novel threonine to proline mutation in the helix termination motif of keratin 1 in epidermolytic hyperkeratosis with severe palmoplantar hyperkeratosis and contractures of the digits.	Threonine	8-17	keratin 1	Homo sapiens	72-81
15888189-0	2005	A novel threonine to proline mutation in the helix termination motif of keratin 1 in epidermolytic hyperkeratosis with severe palmoplantar hyperkeratosis and contractures of the digits.	Proline	21-28	keratin 1	Homo sapiens	72-81
12944405-2	2003	In microtiter plates, biotinylated high molecular weight kininogen (biotin-HK) or biotin-FXI binding to HUVEC monolayers or their matrix proteins, but not fibronectin-coated plastic microtiter plate wells, was specifically blocked by antibodies to each of the receptors of HK, uPAR, gC1qR, or cytokeratin 1.	Biotin	22-28	keratin 1	Homo sapiens	293-306
15514282-3	2004	We examined whether dietary intake of phylloquinone (vitamin K-1) and menaquinone (vitamin K-2) were related to aortic calcification and coronary heart disease (CHD) in the population-based Rotterdam Study.	Vitamin K 1	38-51	keratin 1	Homo sapiens	61-64
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	116-121	keratin 1	Homo sapiens	404-412
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	138-143	keratin 1	Homo sapiens	404-412
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	138-143	keratin 1	Homo sapiens	404-412
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	138-143	keratin 1	Homo sapiens	404-412
18494925-1	2004	About sixty years ago Frank and Evans showed, by entropy measurements, that when a "non-polar molecule dissolves in water it modifies the water structure in the direction of greater "cristallinity", the water builds a microscopic iceberg around it" Now, we propose the "concept of ice-like-water capture": a lowering of organized ice-like water promotes aggregation (loss of solubility) of the filaggrin/keratin1/keratin10 associations through their hydrophobic patches.	Water	138-143	keratin 1	Homo sapiens	404-412
15239088-5	2004	CBF (mL/mL/min), K1 (mL/mL/min), and the ammonia extraction fraction (K1/CBF) showed marked regional variance with the highest levels in the thalamus, the lenticular nucleus, and the cerebellum.	Ammonia	41-48	keratin 1	Homo sapiens	70-77
14691569-5	2004	When biotinylated cytokeratin 1 was incubated with either gC1qR or u-PAR and gel filtered, a new, higher molecular weight peak containing biotin was observed indicating complex formation.	Biotin	5-11	keratin 1	Homo sapiens	18-31
14645716-5	2003	Temperature-dependence studies in 100 mM KCl gave an apparent activation enthalpy and entropy of 6.4 +/- 0.4 kcal.mol-1 and -52.3 +/- 1.4 cal.mol-1.K-1, respectively, indicating that the unfolding is entropically driven and can occur easily.	Potassium Chloride	41-44	keratin 1	Homo sapiens	148-151
14645716-6	2003	In contrast, in 100 mM NaCl the respective values are 14.9 +/- 0.2 kcal.mol-1 and -23.0 +/- 0.8 cal.mol-1.K-1, suggesting a more significant enthalpic barrier.	Sodium Chloride	23-27	keratin 1	Homo sapiens	106-109
15558947-2	2004	Hydrolysis of D-valyl-L-leucyl-L-arginine p-nitroanilide by human tissue kallikrein (hK1) was studied in the absence and in the presence of increasing concentrations of the following chloride salts: sodium, potassium, calcium, magnesium and aluminium.	d-valyl-l-leucyl-l-arginine p-nitroanilide	14-56	keratin 1	Homo sapiens	85-88
15558947-2	2004	Hydrolysis of D-valyl-L-leucyl-L-arginine p-nitroanilide by human tissue kallikrein (hK1) was studied in the absence and in the presence of increasing concentrations of the following chloride salts: sodium, potassium, calcium, magnesium and aluminium.	Chlorides	183-191	keratin 1	Homo sapiens	85-88
15558947-3	2004	The data indicate that the inhibition of hK1 by sodium, potassium, calcium and magnesium is linear competitive and that divalent cations are more potent inhibitors of hK1 than univalent cations.	Sodium	48-54	keratin 1	Homo sapiens	41-44
15558947-3	2004	The data indicate that the inhibition of hK1 by sodium, potassium, calcium and magnesium is linear competitive and that divalent cations are more potent inhibitors of hK1 than univalent cations.	Sodium	48-54	keratin 1	Homo sapiens	167-170
15558947-3	2004	The data indicate that the inhibition of hK1 by sodium, potassium, calcium and magnesium is linear competitive and that divalent cations are more potent inhibitors of hK1 than univalent cations.	Potassium	56-65	keratin 1	Homo sapiens	41-44
15558947-3	2004	The data indicate that the inhibition of hK1 by sodium, potassium, calcium and magnesium is linear competitive and that divalent cations are more potent inhibitors of hK1 than univalent cations.	Calcium	67-74	keratin 1	Homo sapiens	41-44
15558947-3	2004	The data indicate that the inhibition of hK1 by sodium, potassium, calcium and magnesium is linear competitive and that divalent cations are more potent inhibitors of hK1 than univalent cations.	Magnesium	79-88	keratin 1	Homo sapiens	41-44
15558947-4	2004	However the inhibition of hK1 by aluminium cation is linear mixed, with the cation being able to bind to both the free enzyme and the ES complex.	Aluminum	33-42	keratin 1	Homo sapiens	26-29
15558947-4	2004	However the inhibition of hK1 by aluminium cation is linear mixed, with the cation being able to bind to both the free enzyme and the ES complex.	Einsteinium	134-136	keratin 1	Homo sapiens	26-29
15040788-3	2004	However, owing to preferential hydrolysis of Phe-Arg compared with the Arg-Ala bond in the peptide derived from rat LMWK, hK1 released bradykinin only from the mouse LMWK fragment and preferentially released des-[Arg9]bradykinin from the rat LMWK fragment (Abz-MTSVIRRPPGFSPFRAPRV-NH2).	phenylalanylarginine	45-52	keratin 1	Homo sapiens	122-125
15040788-3	2004	However, owing to preferential hydrolysis of Phe-Arg compared with the Arg-Ala bond in the peptide derived from rat LMWK, hK1 released bradykinin only from the mouse LMWK fragment and preferentially released des-[Arg9]bradykinin from the rat LMWK fragment (Abz-MTSVIRRPPGFSPFRAPRV-NH2).	Arginine	49-52	keratin 1	Homo sapiens	122-125
15040788-3	2004	However, owing to preferential hydrolysis of Phe-Arg compared with the Arg-Ala bond in the peptide derived from rat LMWK, hK1 released bradykinin only from the mouse LMWK fragment and preferentially released des-[Arg9]bradykinin from the rat LMWK fragment (Abz-MTSVIRRPPGFSPFRAPRV-NH2).	des-[arg9	208-217	keratin 1	Homo sapiens	122-125
15040788-3	2004	However, owing to preferential hydrolysis of Phe-Arg compared with the Arg-Ala bond in the peptide derived from rat LMWK, hK1 released bradykinin only from the mouse LMWK fragment and preferentially released des-[Arg9]bradykinin from the rat LMWK fragment (Abz-MTSVIRRPPGFSPFRAPRV-NH2).	Amido radical	281-284	keratin 1	Homo sapiens	122-125
15040788-5	2004	One of these peptides, Abz-GFSPFRAPRVQ-EDDnp (where EDDnp stands for ethylenediamine 2,4-dinitrophenyl), was preferentially hydrolysed at the Phe-Arg bond, confirming the potential des-[Arg9]bradykinin-releasing activity of hK1 on rat kininogen.	abz-gfspfraprvq-eddnp	23-44	keratin 1	Homo sapiens	224-227
15040788-5	2004	One of these peptides, Abz-GFSPFRAPRVQ-EDDnp (where EDDnp stands for ethylenediamine 2,4-dinitrophenyl), was preferentially hydrolysed at the Phe-Arg bond, confirming the potential des-[Arg9]bradykinin-releasing activity of hK1 on rat kininogen.	n1-(2,4-dinitrophenyl)ethane-1,2-diamine	39-44	keratin 1	Homo sapiens	224-227
15040788-5	2004	One of these peptides, Abz-GFSPFRAPRVQ-EDDnp (where EDDnp stands for ethylenediamine 2,4-dinitrophenyl), was preferentially hydrolysed at the Phe-Arg bond, confirming the potential des-[Arg9]bradykinin-releasing activity of hK1 on rat kininogen.	Phenylalanine	142-145	keratin 1	Homo sapiens	224-227
15040788-5	2004	One of these peptides, Abz-GFSPFRAPRVQ-EDDnp (where EDDnp stands for ethylenediamine 2,4-dinitrophenyl), was preferentially hydrolysed at the Phe-Arg bond, confirming the potential des-[Arg9]bradykinin-releasing activity of hK1 on rat kininogen.	Arginine	146-149	keratin 1	Homo sapiens	224-227
15040788-6	2004	The proline residue that is two residues upstream of bradykinin in rat kininogen is, in part, responsible for this pattern of hydrolysis, since the peptide Abz-GFSPFRASRVQ-EDDnp was preferentially cleaved at the Arg-Ala bond by hK1.	Proline	4-11	keratin 1	Homo sapiens	228-231
14629481-2	2003	Proteins such as gC1qR, cytokeratin-1 and u-PAR have been identified to be responsible for Zn2+-dependent binding of high molecular weight kininogen (HK) to HUVEC.	Zinc	91-95	keratin 1	Homo sapiens	24-37
14667156-3	2003	Consistency with the defined Sauerbrey and Kanazawa terms K1 and K2 when applied to multiple frequencies was found for these specific operating conditions in terms of a significant fit between the measured and calculated values: For an IgG surface density of 13.5 ng mm(-2) the measured value of K1 is 22.5 x 10(-6) and the calculated value is 20.4 x 10(-6), whilst for glycerol viscous loadings of 5.131 cP the measured value of K2 is 0.47 and the calculated value is 0.54.	Glycerol	370-378	keratin 1	Homo sapiens	58-67
12843286-3	2003	Although vitamin K is not a classical antioxidant, we report here the novel finding that vitamin K1 and K2 (menaquinone-4) potently inhibit glutathione depletion-mediated oxidative cell death in primary cultures of oligodendrocyte precursors and immature fetal cortical neurons with EC50 values of 30 nm and 2 nm, respectively.	Vitamin K	9-18	keratin 1	Homo sapiens	97-106
12843286-3	2003	Although vitamin K is not a classical antioxidant, we report here the novel finding that vitamin K1 and K2 (menaquinone-4) potently inhibit glutathione depletion-mediated oxidative cell death in primary cultures of oligodendrocyte precursors and immature fetal cortical neurons with EC50 values of 30 nm and 2 nm, respectively.	menatetrenone	108-121	keratin 1	Homo sapiens	97-106
12843286-3	2003	Although vitamin K is not a classical antioxidant, we report here the novel finding that vitamin K1 and K2 (menaquinone-4) potently inhibit glutathione depletion-mediated oxidative cell death in primary cultures of oligodendrocyte precursors and immature fetal cortical neurons with EC50 values of 30 nm and 2 nm, respectively.	Glutathione	140-151	keratin 1	Homo sapiens	97-106
12663686-4	2003	EGCG elicited cell differentiation with associated induction of p57/KIP2 within 24 h in growing keratinocytes, measured by the expression of keratin 1, filaggrin, and transglutaminase activity.	epigallocatechin gallate	0-4	keratin 1	Homo sapiens	141-150
12383084-4	2002	Ca2+ channel activity decayed rapidly in excised patches, and recovered on adding ATP (K1/2, 1.3 +/- 0.7 mm) but not the non-hydrolyzable analog ATPgammaS.	Adenosine Triphosphate	82-85	keratin 1	Homo sapiens	87-96
12578561-3	2003	Serine and arginine are also the residues at positions P"(1) and P"(2) in human kininogen, from which hK1 releases Lys-bradykinin.	Serine	0-6	keratin 1	Homo sapiens	102-105
12578561-3	2003	Serine and arginine are also the residues at positions P"(1) and P"(2) in human kininogen, from which hK1 releases Lys-bradykinin.	Arginine	11-19	keratin 1	Homo sapiens	102-105
12578561-7	2003	Abz-Lys-Phe-Phe-Pro-Arg-Gln-EDDnp, Abz-Lys-Phe-Arg-Pro-Arg-Gln-EDDnp and acetyl-Lys-Phe-Phe-Pro-Leu-Glu-NH(2) inhibited hK1 in the range 20-30 nM (letters in italics denote the D-form of the amino acid).	abz-lys-phe-phe-pro-arg-gln-eddnp	0-33	keratin 1	Homo sapiens	120-123
12578561-8	2003	The peptide acetyl-Lys-Phe-Phe-Pro-Leu-Glu-NH(2) was a weak inhibitor for other serine proteases, as indicated by the higher K (i) values compared with hK1, but this peptide was a potent inhibitor of human plasma kallikrein, which has a K (i) value of 8 nM.	-leu-glu-nh(2)	34-48	keratin 1	Homo sapiens	152-155
12578561-10	2003	In conclusion, acetyl-Lys-Phe-Phe-Pro-Leu-Glu-NH(2) can be used as a leader compound to design specific inhibitors for hK1, plasma kallikrein, or for both at same time, if the inhibition of kinin release is the main goal.	acetyl-Lys-Phe-Phe-Pro-Leu-Glu-NH(2)	15-51	keratin 1	Homo sapiens	119-122