PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 2558648-4 1989 Hydroxylated derivatives of arachidonic acid, including prostaglandins, leukotriene B4, 5-hydroxyeicosa 6E, 8Z, 11Z, 14Z-tetraenoic acid, 12-hydroxyeicosa 5Z, 8Z, 10E, 14Z-tetraenoic acid and 15-hydroxyeicosa 5Z, 8Z, 11Z, 13E-tetraenoic acid increased in cells after rIL-1 beta treatment. Arachidonic Acid 28-44 interleukin 1 beta Rattus norvegicus 267-277 2553025-3 1989 When stimulated by appropriate concentrations of recombinant interleukin-1 beta (rIL-1 beta), ASC proliferate and produce PGE. Prostaglandins E 122-125 interleukin 1 beta Rattus norvegicus 81-91 2573510-3 1989 The iv or intracerebroventricular injection of either Il-1 alpha or Il-1 beta caused dose-related increases in plasma ACTH, epinephrine, and norepinephrine levels. Epinephrine 124-135 interleukin 1 beta Rattus norvegicus 68-77 2573510-3 1989 The iv or intracerebroventricular injection of either Il-1 alpha or Il-1 beta caused dose-related increases in plasma ACTH, epinephrine, and norepinephrine levels. Norepinephrine 141-155 interleukin 1 beta Rattus norvegicus 68-77 2573510-6 1989 Similarly, Il-1 alpha was more effective than Il-1 beta at stimulating epinephrine, but not norepinephrine, secretion after icv injection. Epinephrine 71-82 interleukin 1 beta Rattus norvegicus 46-55 2573510-9 1989 These results suggest that both Il-1 alpha and Il-1 beta stimulate ACTH and catecholamine secretion in the rat. Catecholamines 76-89 interleukin 1 beta Rattus norvegicus 47-56 2553025-4 1989 DGLA-enriched medium suppressed both baseline and rIL-1 beta-stimulated ASC growth fivefold, compared with medium supplemented with arachidonic acid. 8,11,14-Eicosatrienoic Acid 0-4 interleukin 1 beta Rattus norvegicus 50-60 2553025-6 1989 Synovial cells incorporated the DGLA, and rIL-1 beta-stimulated cells that were incubated with DGLA exhibited a 14-fold increase in PGE1 (to 25.2 +/- 6.0 ng/ml, mean +/- SD) and a 70% decrease in PGE2 (to 25.2 +/- 4.2 ng/ml) compared with cells in control medium. 8,11,14-Eicosatrienoic Acid 95-99 interleukin 1 beta Rattus norvegicus 42-52 2553025-6 1989 Synovial cells incorporated the DGLA, and rIL-1 beta-stimulated cells that were incubated with DGLA exhibited a 14-fold increase in PGE1 (to 25.2 +/- 6.0 ng/ml, mean +/- SD) and a 70% decrease in PGE2 (to 25.2 +/- 4.2 ng/ml) compared with cells in control medium. Alprostadil 132-136 interleukin 1 beta Rattus norvegicus 42-52 2553025-6 1989 Synovial cells incorporated the DGLA, and rIL-1 beta-stimulated cells that were incubated with DGLA exhibited a 14-fold increase in PGE1 (to 25.2 +/- 6.0 ng/ml, mean +/- SD) and a 70% decrease in PGE2 (to 25.2 +/- 4.2 ng/ml) compared with cells in control medium. Dinoprostone 196-200 interleukin 1 beta Rattus norvegicus 42-52 2697686-4 1989 In the rat islets [3H]thymidine incorporation was decreased by 20% 5 h after exposure to 25 U/ml rIL-1 beta. Tritium 19-21 interleukin 1 beta Rattus norvegicus 97-107 2676656-4 1989 In 11 mM glucose, 2000 ng/L of IL-1 beta caused inhibition of insulin release after approximately 6 h of exposure to IL-1 beta; in 3.3 mM glucose culture, onset of inhibition was delayed by this IL-1 beta concentration until after 48 h of exposure. Glucose 9-16 interleukin 1 beta Rattus norvegicus 31-40 2676656-4 1989 In 11 mM glucose, 2000 ng/L of IL-1 beta caused inhibition of insulin release after approximately 6 h of exposure to IL-1 beta; in 3.3 mM glucose culture, onset of inhibition was delayed by this IL-1 beta concentration until after 48 h of exposure. Glucose 138-145 interleukin 1 beta Rattus norvegicus 31-40 2676656-5 1989 Similarly, stimulation and suppression of beta-cell function with L-leucine and SMS 201-995, respectively, resulted in acceleration and delay of IL-1 beta-mediated inhibition. Leucine 66-75 interleukin 1 beta Rattus norvegicus 145-154 2697686-4 1989 In the rat islets [3H]thymidine incorporation was decreased by 20% 5 h after exposure to 25 U/ml rIL-1 beta. Thymidine 22-31 interleukin 1 beta Rattus norvegicus 97-107 2697686-6 1989 In the RINm5F cells there was a dose-dependent inhibition of the cell replication to approximately 50% of the controls in cells exposed to 25 U/ml rIL-1 beta for 48 h. This was also accompanied by an increased cell death, as measured by trypan blue inclusion (controls 13% and rIL-1 beta treated cells 25%). Trypan Blue 237-248 interleukin 1 beta Rattus norvegicus 147-157 2697686-9 1989 rIL-1 beta decreased the cellular content of the polyamines spermidine and spermine. Polyamines 49-59 interleukin 1 beta Rattus norvegicus 0-10 2697686-9 1989 rIL-1 beta decreased the cellular content of the polyamines spermidine and spermine. Spermidine 60-70 interleukin 1 beta Rattus norvegicus 0-10 2697686-9 1989 rIL-1 beta decreased the cellular content of the polyamines spermidine and spermine. Spermine 75-83 interleukin 1 beta Rattus norvegicus 0-10 2570864-0 1989 Studies on interleukin-1 beta induced glycosaminoglycan release from rat femoral head cartilage in-vitro. Glycosaminoglycans 38-55 interleukin 1 beta Rattus norvegicus 11-29 2508388-0 1989 Modulation of calcium flux influences interleukin 1 beta effects on insulin release from isolated islets of Langerhans. Calcium 14-21 interleukin 1 beta Rattus norvegicus 38-56 2804553-0 1989 Inhibition by neuropeptides of interleukin-1 beta-induced, prostaglandin-independent hyperalgesia. Prostaglandins 59-72 interleukin 1 beta Rattus norvegicus 31-49 2804553-5 1989 These observations indicate that IL-1 beta sensitized pressure-sensitive but not temperature-sensitive sensory neurones, through a prostaglandin-independent mechanism. Prostaglandins 131-144 interleukin 1 beta Rattus norvegicus 33-42 2804553-6 1989 Hyperalgesia induced by IL-1 beta but not PGE2, was inhibited by the neuropeptide melanocyte-stimulating hormone (alpha MSH) and its analogue [Nle4, D-Phe7] alpha MSH which are known to antagonize IL-1 responses in other systems (Holdeman & Lipton, 1985; Cannon et al., 1986). nle4 143-147 interleukin 1 beta Rattus norvegicus 24-33 2804553-6 1989 Hyperalgesia induced by IL-1 beta but not PGE2, was inhibited by the neuropeptide melanocyte-stimulating hormone (alpha MSH) and its analogue [Nle4, D-Phe7] alpha MSH which are known to antagonize IL-1 responses in other systems (Holdeman & Lipton, 1985; Cannon et al., 1986). d-phe7 149-155 interleukin 1 beta Rattus norvegicus 24-33 2804553-6 1989 Hyperalgesia induced by IL-1 beta but not PGE2, was inhibited by the neuropeptide melanocyte-stimulating hormone (alpha MSH) and its analogue [Nle4, D-Phe7] alpha MSH which are known to antagonize IL-1 responses in other systems (Holdeman & Lipton, 1985; Cannon et al., 1986). holdeman & 230-243 interleukin 1 beta Rattus norvegicus 24-33 2804553-6 1989 Hyperalgesia induced by IL-1 beta but not PGE2, was inhibited by the neuropeptide melanocyte-stimulating hormone (alpha MSH) and its analogue [Nle4, D-Phe7] alpha MSH which are known to antagonize IL-1 responses in other systems (Holdeman & Lipton, 1985; Cannon et al., 1986). lipton 245-251 interleukin 1 beta Rattus norvegicus 24-33 2666106-8 1989 The rIL-1 beta-treated islets showed a marked reduction of glucose-stimulated insulin release. Glucose 59-66 interleukin 1 beta Rattus norvegicus 4-14 2666106-9 1989 Stimulation with arginine plus different glucose concentrations, and leucine plus glutamine partially counteracted the rIL-1 beta-induced reduction of insulin release. Arginine 17-25 interleukin 1 beta Rattus norvegicus 119-129 2666106-9 1989 Stimulation with arginine plus different glucose concentrations, and leucine plus glutamine partially counteracted the rIL-1 beta-induced reduction of insulin release. Leucine 69-76 interleukin 1 beta Rattus norvegicus 119-129 2666106-9 1989 Stimulation with arginine plus different glucose concentrations, and leucine plus glutamine partially counteracted the rIL-1 beta-induced reduction of insulin release. Glutamine 82-91 interleukin 1 beta Rattus norvegicus 119-129 2808341-1 1989 Recombinant human interleukin-1 beta (rIL-1 beta) was chemically modified by a 10-fold molar excess (reagent:protein) of sulfosuccinimidyl 6-(biotinamido) hexanoate (sulfo-NHS-LC-biotin) or sulfosuccinimidobiotin (sulfo-NHS-biotin) under mild conditions. sulfosuccinimidyl 6-(biotinamido)hexanoate 121-164 interleukin 1 beta Rattus norvegicus 38-48 2808341-1 1989 Recombinant human interleukin-1 beta (rIL-1 beta) was chemically modified by a 10-fold molar excess (reagent:protein) of sulfosuccinimidyl 6-(biotinamido) hexanoate (sulfo-NHS-LC-biotin) or sulfosuccinimidobiotin (sulfo-NHS-biotin) under mild conditions. sulfosuccinimidyl 6-(biotinamido)hexanoate 166-185 interleukin 1 beta Rattus norvegicus 38-48 2808341-1 1989 Recombinant human interleukin-1 beta (rIL-1 beta) was chemically modified by a 10-fold molar excess (reagent:protein) of sulfosuccinimidyl 6-(biotinamido) hexanoate (sulfo-NHS-LC-biotin) or sulfosuccinimidobiotin (sulfo-NHS-biotin) under mild conditions. biotinyl-N-hydroxysulfosuccinimide ester 190-212 interleukin 1 beta Rattus norvegicus 38-48 2808341-1 1989 Recombinant human interleukin-1 beta (rIL-1 beta) was chemically modified by a 10-fold molar excess (reagent:protein) of sulfosuccinimidyl 6-(biotinamido) hexanoate (sulfo-NHS-LC-biotin) or sulfosuccinimidobiotin (sulfo-NHS-biotin) under mild conditions. sulfo-N-hydroxysuccinimide-biotin 214-230 interleukin 1 beta Rattus norvegicus 38-48 2808341-5 1989 Chromatography of intact biotinylated rIL-1 beta by C4 reverse phase HPLC resolved a protein modified exclusively at the N-terminal alanine from two proteins modified singly at either lysine 93 or lysine 94. Alanine 132-139 interleukin 1 beta Rattus norvegicus 38-48 2808341-5 1989 Chromatography of intact biotinylated rIL-1 beta by C4 reverse phase HPLC resolved a protein modified exclusively at the N-terminal alanine from two proteins modified singly at either lysine 93 or lysine 94. Lysine 184-190 interleukin 1 beta Rattus norvegicus 38-48 2808341-5 1989 Chromatography of intact biotinylated rIL-1 beta by C4 reverse phase HPLC resolved a protein modified exclusively at the N-terminal alanine from two proteins modified singly at either lysine 93 or lysine 94. Lysine 197-203 interleukin 1 beta Rattus norvegicus 38-48 2808341-6 1989 In addition, a protein product modified at lysine 103 was also obtained when rIL-1 beta was similarly modified with sulfo-NHS-biotin. Lysine 43-49 interleukin 1 beta Rattus norvegicus 77-87 2808341-6 1989 In addition, a protein product modified at lysine 103 was also obtained when rIL-1 beta was similarly modified with sulfo-NHS-biotin. sulfo-N-hydroxysuccinimide-biotin 116-132 interleukin 1 beta Rattus norvegicus 77-87 2501001-0 1989 Recombinant interleukin-1 beta stimulates eicosanoid production in rat primary culture astrocytes. Eicosanoids 42-52 interleukin 1 beta Rattus norvegicus 12-30 2784674-2 1989 rIL-1 beta is significantly more potent than rIL-1 alpha or rTNF in stimulating PGE2 as well as PLA2 release from mesangial cells. Dinoprostone 80-84 interleukin 1 beta Rattus norvegicus 0-10 2801329-4 1989 PGE2 release significantly increased (p less than 0.05) when the chondrocytes were incubated with rIL-1 beta, bFGF and EGF alone, but not with rTNF alpha above. Dinoprostone 0-4 interleukin 1 beta Rattus norvegicus 98-108 2785913-0 1989 Interleukin-1 beta increases prostaglandin E2 in rat astrocyte cultures: modulatory effect of neuropeptides. Dinoprostone 29-45 interleukin 1 beta Rattus norvegicus 0-18 2785913-2 1989 The minimum effective dose of IL-1 beta was 10(-10)M. IL-1 alpha also increased PGE2, but at a higher concentration. Dinoprostone 80-84 interleukin 1 beta Rattus norvegicus 30-39 2785913-5 1989 PGE2 response to IL-1 beta was suppressed by simultaneous addition of CRH, somatostatin-14 and LHRH, while these neuropeptides alone did not alter the basal PGE2 levels. Dinoprostone 0-4 interleukin 1 beta Rattus norvegicus 17-26 2656735-5 1989 Recombinant IL-1 beta (rIL-1 beta) also stimulated [3H]thymidine incorporation into thyrocytes from normal subjects and patients with Graves" disease, and it increased the proportion of thyrocytes in the S phase of the cell cycle. Tritium 52-54 interleukin 1 beta Rattus norvegicus 23-33 2656735-5 1989 Recombinant IL-1 beta (rIL-1 beta) also stimulated [3H]thymidine incorporation into thyrocytes from normal subjects and patients with Graves" disease, and it increased the proportion of thyrocytes in the S phase of the cell cycle. Thymidine 55-64 interleukin 1 beta Rattus norvegicus 23-33 2656735-6 1989 Furthermore, thyrocytes stimulated with rIL-1 beta for 24 h produced significant amounts of prostaglandin E2. Dinoprostone 92-108 interleukin 1 beta Rattus norvegicus 40-50 2656735-7 1989 Indomethacin inhibited completely the rIL-1 beta-stimulated prostaglandin E2 production and increased markedly [3H]thymidine incorporation. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 38-48 2656735-7 1989 Indomethacin inhibited completely the rIL-1 beta-stimulated prostaglandin E2 production and increased markedly [3H]thymidine incorporation. Dinoprostone 60-76 interleukin 1 beta Rattus norvegicus 38-48 2656735-7 1989 Indomethacin inhibited completely the rIL-1 beta-stimulated prostaglandin E2 production and increased markedly [3H]thymidine incorporation. Tritium 112-114 interleukin 1 beta Rattus norvegicus 38-48 2656735-7 1989 Indomethacin inhibited completely the rIL-1 beta-stimulated prostaglandin E2 production and increased markedly [3H]thymidine incorporation. Thymidine 115-124 interleukin 1 beta Rattus norvegicus 38-48 2785913-8 1989 Combined addition of AII and IL-1 beta induced a synergistic effect in increasing PGE2 levels. Dinoprostone 82-86 interleukin 1 beta Rattus norvegicus 29-38 2784674-3 1989 When given together, rTNF interacts in a synergistic fashion with rIL-1 alpha and rIL-1 beta to enhance both, PGE2 synthesis and PLA2 release. Dinoprostone 110-114 interleukin 1 beta Rattus norvegicus 82-92 2785834-2 1989 Human embryonic skin fibroblasts (HSF) incubated overnight with either human recombinant interleukin-1 alpha (rIL-1 alpha) or interleukin-1 beta (rIL-1 beta) released large amounts of prostaglandin E2 (PGE2). Dinoprostone 184-200 interleukin 1 beta Rattus norvegicus 146-156 2785834-2 1989 Human embryonic skin fibroblasts (HSF) incubated overnight with either human recombinant interleukin-1 alpha (rIL-1 alpha) or interleukin-1 beta (rIL-1 beta) released large amounts of prostaglandin E2 (PGE2). Dinoprostone 202-206 interleukin 1 beta Rattus norvegicus 146-156 2785834-6 1989 Hydrocortisone inhibited the PGE2 release induced by rIL-1 beta and Bk, but not by AA. Hydrocortisone 0-14 interleukin 1 beta Rattus norvegicus 53-70 2785834-4 1989 rIL-1 beta, bradykinin (Bk) and arachidonic acid (AA) significantly stimulated PGE2 release from HSF incubated overnight in the presence of either interleukin. Dinoprostone 79-83 interleukin 1 beta Rattus norvegicus 0-10 2785834-6 1989 Hydrocortisone inhibited the PGE2 release induced by rIL-1 beta and Bk, but not by AA. Dinoprostone 29-33 interleukin 1 beta Rattus norvegicus 53-70 2788629-2 1989 IL-1 beta also stimulated resting oxygen consumption (VO2) by 38 percent, in vitro thermogenic activity (mitochondrial GDP binding) of brown adipose tissue (BAT) by almost two-fold, and blood flow to brown fat (assessed from the distribution of radiolabelled microspheres) by nine-fold in lean animals. Oxygen 34-40 interleukin 1 beta Rattus norvegicus 0-9 2785834-12 1989 The stimulation of PLA2 activity by rIL-1 beta is inhibited by hydrocortisone, probably via induction of lipocortin-like proteins. Hydrocortisone 63-77 interleukin 1 beta Rattus norvegicus 36-46 2501121-4 1989 However, in the presence of FSH, both IL-1 alpha and IL-1 beta inhibited, in a dose-dependent manner, progesterone and estrogen production as well as LH/hCG receptor induction in response to FSH. Progesterone 102-114 interleukin 1 beta Rattus norvegicus 53-62 2783533-3 1989 IL-1 beta increased resting oxygen consumption by 25-49% in a dose-dependent manner. Oxygen 28-34 interleukin 1 beta Rattus norvegicus 0-9 2788629-2 1989 IL-1 beta also stimulated resting oxygen consumption (VO2) by 38 percent, in vitro thermogenic activity (mitochondrial GDP binding) of brown adipose tissue (BAT) by almost two-fold, and blood flow to brown fat (assessed from the distribution of radiolabelled microspheres) by nine-fold in lean animals. Guanosine Diphosphate 119-122 interleukin 1 beta Rattus norvegicus 0-9 3051564-11 1988 Cyclosporine significantly augmented the level of TPL activity in HUVEC stimulated with rIL-1 alpha, rIL-1 beta, and rTNF alpha and in MNC and M stimulated with rIL-1 alpha, rIL-1 beta, and rIL-2. Cyclosporine 0-12 interleukin 1 beta Rattus norvegicus 101-127 2785913-10 1989 In view of the essential role of central PGE2 in IL-1 beta-induced CRH/ACTH release, these findings suggest the presence of a sophisticated regulatory network in the immune-neuroendocrine interaction. Dinoprostone 41-45 interleukin 1 beta Rattus norvegicus 49-58 2847761-2 1988 Tritiated arachidonic acid (3H-AA)-labeled rat synovial fibroblasts stimulated with human recombinant interleukin-1 beta (rIL-1 beta) released incorporated radiolabel in a time-dependent and dose-dependent manner, with labeled prostaglandins representing 29% of the released radiolabel. 3h-aa 28-33 interleukin 1 beta Rattus norvegicus 122-132 2847761-2 1988 Tritiated arachidonic acid (3H-AA)-labeled rat synovial fibroblasts stimulated with human recombinant interleukin-1 beta (rIL-1 beta) released incorporated radiolabel in a time-dependent and dose-dependent manner, with labeled prostaglandins representing 29% of the released radiolabel. Prostaglandins 227-241 interleukin 1 beta Rattus norvegicus 122-132 2847761-3 1988 Treatment of the cells with dibutyryl cAMP or prostaglandin E2 enhanced both spontaneous and rIL-1 beta-induced 3H-AA release; treatment with indomethacin or naproxen inhibited the response. Bucladesine 28-42 interleukin 1 beta Rattus norvegicus 93-103 2847761-3 1988 Treatment of the cells with dibutyryl cAMP or prostaglandin E2 enhanced both spontaneous and rIL-1 beta-induced 3H-AA release; treatment with indomethacin or naproxen inhibited the response. Dinoprostone 46-62 interleukin 1 beta Rattus norvegicus 93-103 2847761-3 1988 Treatment of the cells with dibutyryl cAMP or prostaglandin E2 enhanced both spontaneous and rIL-1 beta-induced 3H-AA release; treatment with indomethacin or naproxen inhibited the response. 3h-aa 112-117 interleukin 1 beta Rattus norvegicus 93-103 2847761-3 1988 Treatment of the cells with dibutyryl cAMP or prostaglandin E2 enhanced both spontaneous and rIL-1 beta-induced 3H-AA release; treatment with indomethacin or naproxen inhibited the response. Naproxen 158-166 interleukin 1 beta Rattus norvegicus 93-103 2847761-7 1988 These data show that rIL-1 beta stimulates phospholipase activities in rat synovial fibroblasts and that at least one of these activities may be regulated by either prostaglandins or cAMP. Prostaglandins 165-179 interleukin 1 beta Rattus norvegicus 21-31 2847761-7 1988 These data show that rIL-1 beta stimulates phospholipase activities in rat synovial fibroblasts and that at least one of these activities may be regulated by either prostaglandins or cAMP. Cyclic AMP 183-187 interleukin 1 beta Rattus norvegicus 21-31 3051564-11 1988 Cyclosporine significantly augmented the level of TPL activity in HUVEC stimulated with rIL-1 alpha, rIL-1 beta, and rTNF alpha and in MNC and M stimulated with rIL-1 alpha, rIL-1 beta, and rIL-2. Cyclosporine 0-12 interleukin 1 beta Rattus norvegicus 101-111 3069712-2 1988 The rIL-1 beta is purified to apparent homogeneity using freeze-thaw extractions followed by hydrophobic interaction chromatography over phenyl Sepharose. phenyl-sepharose 137-153 interleukin 1 beta Rattus norvegicus 4-14 3257505-3 1988 rTNF alpha, as well as rIL-1 alpha and rIL-1 beta, decreased the incorporation of [35S]sulfate into glycosaminoglycan to about 10% of the levels in the control. [35s]sulfate 82-94 interleukin 1 beta Rattus norvegicus 39-49 2851750-0 1988 Human recombinant interleukin-1 beta and -alpha, but not recombinant tumor necrosis factor alpha stimulate ACTH release from rat anterior pituitary cells in vitro in a prostaglandin E2 and cAMP independent manner. Dinoprostone 168-184 interleukin 1 beta Rattus norvegicus 18-47 2851750-0 1988 Human recombinant interleukin-1 beta and -alpha, but not recombinant tumor necrosis factor alpha stimulate ACTH release from rat anterior pituitary cells in vitro in a prostaglandin E2 and cAMP independent manner. Cyclic AMP 189-193 interleukin 1 beta Rattus norvegicus 18-47 3260876-2 1988 In the presence of low concentrations of LH or in its absence interleukin-1 beta markedly stimulates the production of C19-steroids (testosterone and androstenedione) and C21-steroids (progesterone, 17 alpha-hydroxyprogesterone, 20 alpha-hydroxypregn-4-en-3-one). c19-steroids 119-131 interleukin 1 beta Rattus norvegicus 62-80 3260876-2 1988 In the presence of low concentrations of LH or in its absence interleukin-1 beta markedly stimulates the production of C19-steroids (testosterone and androstenedione) and C21-steroids (progesterone, 17 alpha-hydroxyprogesterone, 20 alpha-hydroxypregn-4-en-3-one). Testosterone 133-145 interleukin 1 beta Rattus norvegicus 62-80 3260876-2 1988 In the presence of low concentrations of LH or in its absence interleukin-1 beta markedly stimulates the production of C19-steroids (testosterone and androstenedione) and C21-steroids (progesterone, 17 alpha-hydroxyprogesterone, 20 alpha-hydroxypregn-4-en-3-one). Androstenedione 150-165 interleukin 1 beta Rattus norvegicus 62-80 3260876-2 1988 In the presence of low concentrations of LH or in its absence interleukin-1 beta markedly stimulates the production of C19-steroids (testosterone and androstenedione) and C21-steroids (progesterone, 17 alpha-hydroxyprogesterone, 20 alpha-hydroxypregn-4-en-3-one). Pregnanes 171-183 interleukin 1 beta Rattus norvegicus 62-80 3260876-2 1988 In the presence of low concentrations of LH or in its absence interleukin-1 beta markedly stimulates the production of C19-steroids (testosterone and androstenedione) and C21-steroids (progesterone, 17 alpha-hydroxyprogesterone, 20 alpha-hydroxypregn-4-en-3-one). Progesterone 185-197 interleukin 1 beta Rattus norvegicus 62-80 3260876-2 1988 In the presence of low concentrations of LH or in its absence interleukin-1 beta markedly stimulates the production of C19-steroids (testosterone and androstenedione) and C21-steroids (progesterone, 17 alpha-hydroxyprogesterone, 20 alpha-hydroxypregn-4-en-3-one). 17-alpha-Hydroxyprogesterone 202-227 interleukin 1 beta Rattus norvegicus 62-80 3260876-2 1988 In the presence of low concentrations of LH or in its absence interleukin-1 beta markedly stimulates the production of C19-steroids (testosterone and androstenedione) and C21-steroids (progesterone, 17 alpha-hydroxyprogesterone, 20 alpha-hydroxypregn-4-en-3-one). alpha-hydroxypregn-4-en-3-one 232-261 interleukin 1 beta Rattus norvegicus 62-80 3260876-3 1988 In the presence of maximally effective concentrations of LH, on the contrary, interleukin-1 beta inhibits C19-steroid production by provoking a block at the level of the 17,20-desmolase. Luteinizing Hormone 57-59 interleukin 1 beta Rattus norvegicus 78-96 3260876-3 1988 In the presence of maximally effective concentrations of LH, on the contrary, interleukin-1 beta inhibits C19-steroid production by provoking a block at the level of the 17,20-desmolase. c19-steroid 106-117 interleukin 1 beta Rattus norvegicus 78-96 2834174-6 1988 Pretreatment with indomethacin completely prevented the ACTH response induced by either iv or icv injection of IL-1 beta. Indomethacin 18-30 interleukin 1 beta Rattus norvegicus 111-120 2834174-11 1988 It is also suggested that prostaglandins may be involved in this central action of IL-1 beta. Prostaglandins 26-40 interleukin 1 beta Rattus norvegicus 83-92 3257505-3 1988 rTNF alpha, as well as rIL-1 alpha and rIL-1 beta, decreased the incorporation of [35S]sulfate into glycosaminoglycan to about 10% of the levels in the control. Glycosaminoglycans 100-117 interleukin 1 beta Rattus norvegicus 39-49 3257505-4 1988 The half-maximal doses of rTNF alpha, rIL-1 alpha or rIL-1 beta required for the suppression of glycosaminoglycan synthesis (by rTNF alpha, rIL-1 alpha, and rIL-1 beta) were 2 ng/ml, 30 ng/ml, or 5 ng/ml, respectively. Glycosaminoglycans 96-113 interleukin 1 beta Rattus norvegicus 53-63 3257505-4 1988 The half-maximal doses of rTNF alpha, rIL-1 alpha or rIL-1 beta required for the suppression of glycosaminoglycan synthesis (by rTNF alpha, rIL-1 alpha, and rIL-1 beta) were 2 ng/ml, 30 ng/ml, or 5 ng/ml, respectively. Glycosaminoglycans 96-113 interleukin 1 beta Rattus norvegicus 157-167 2840656-4 1988 Concentrated solutions of rIL-1 beta have produced crystals by ammonium sulfate precipitation. Ammonium Sulfate 63-79 interleukin 1 beta Rattus norvegicus 26-36 3307775-2 1987 The purified rIL-1 beta had a molecular weight of 18 kD on SDS-polyacrylamide gel electrophoresis and an isoelectric point of 6.9 on analytical isoelectric focusing. Sodium Dodecyl Sulfate 59-62 interleukin 1 beta Rattus norvegicus 13-23 3320203-5 1987 A half-maximal inhibition of glucose-stimulated insulin release after 7 days of culture was obtained with 100 pg/ml of rIL-1 beta, whereas 1000 pg/ml of rIL-1 alpha were necessary to obtain an equivalent effect. Glucose 29-36 interleukin 1 beta Rattus norvegicus 119-129 3497207-5 1987 The linear portion of the standard curve from an ELISA against rIL-1 beta ranged from 0.5 to 10.0 half-maximal units of [3H]thymidine incorporation in mouse thymocyte cultures. Tritium 121-123 interleukin 1 beta Rattus norvegicus 63-73 2825480-4 1987 In addition, the putative DMARD"s, auranofin, dapsone, and levamisole were effective inhibitors of rIL-1 beta induced inflammation. Auranofin 35-44 interleukin 1 beta Rattus norvegicus 99-109 2825480-4 1987 In addition, the putative DMARD"s, auranofin, dapsone, and levamisole were effective inhibitors of rIL-1 beta induced inflammation. Dapsone 46-53 interleukin 1 beta Rattus norvegicus 99-109 2825480-4 1987 In addition, the putative DMARD"s, auranofin, dapsone, and levamisole were effective inhibitors of rIL-1 beta induced inflammation. Levamisole 59-69 interleukin 1 beta Rattus norvegicus 99-109 3307775-2 1987 The purified rIL-1 beta had a molecular weight of 18 kD on SDS-polyacrylamide gel electrophoresis and an isoelectric point of 6.9 on analytical isoelectric focusing. polyacrylamide 63-77 interleukin 1 beta Rattus norvegicus 13-23 2949012-6 1987 Native and rIL 1 beta co-migrated on SDS-polyacrylamide gels as 17.5 kd polypeptides and reacted with specific polyclonal antisera raised to three synthetic peptides of human IL 1 beta in immunoblot experiments. Sodium Dodecyl Sulfate 37-40 interleukin 1 beta Rattus norvegicus 11-21 3494807-3 1987 rIL-1 beta also stimulated the production of PGE2 by smooth muscle cells. Dinoprostone 45-49 interleukin 1 beta Rattus norvegicus 0-10 3034296-1 1987 Human recombinant interleukin-1 beta (rIL-1 beta) stimulated glycosaminoglycan (GAG) production in human synovial fibroblast cultures. Glycosaminoglycans 61-78 interleukin 1 beta Rattus norvegicus 38-48 3034296-5 1987 Indomethacin (5 micrograms/ml) completely inhibited PGE stimulation by rIL-1 beta, but only partially inhibited that of GAG overproduction and had no effect on collagenase production. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 71-81 3034296-5 1987 Indomethacin (5 micrograms/ml) completely inhibited PGE stimulation by rIL-1 beta, but only partially inhibited that of GAG overproduction and had no effect on collagenase production. Prostaglandins E 52-55 interleukin 1 beta Rattus norvegicus 71-81 3301852-9 1987 S-Carboxamidomethyl-Cys-rIL-1 beta retained biological activity in the IL-2 induction assay. Cysteine 19-23 interleukin 1 beta Rattus norvegicus 24-34 3029119-5 1987 At saturating concentrations, both rIL-1 alpha and rIL-1 beta induce a simultaneous rise in intracellular pH and sodium concentration. Sodium 113-119 interleukin 1 beta Rattus norvegicus 51-61 2949012-6 1987 Native and rIL 1 beta co-migrated on SDS-polyacrylamide gels as 17.5 kd polypeptides and reacted with specific polyclonal antisera raised to three synthetic peptides of human IL 1 beta in immunoblot experiments. polyacrylamide 41-55 interleukin 1 beta Rattus norvegicus 11-21 2949012-7 1987 Amino acid sequence analysis of rIL 1 beta showed that the native amino terminus, an ALA residue, was faithfully maintained. Alanine 85-88 interleukin 1 beta Rattus norvegicus 32-42 3103171-2 1986 Recombinant IL-1 alpha was 3 times more effective than rIL-1 beta at stimulating arachidonic acid metabolism by the primate smooth muscle cells. Arachidonic Acid 81-97 interleukin 1 beta Rattus norvegicus 55-65 3103171-3 1986 Recombinant IL-1 alpha was 3 times less effective than rIL-1 beta when measured by their capacity to synergistically stimulate arachidonic acid metabolism of rat liver cells in the presence of palytoxin and anti-diuretic hormone (ADH). Arachidonic Acid 127-143 interleukin 1 beta Rattus norvegicus 55-65 3103171-3 1986 Recombinant IL-1 alpha was 3 times less effective than rIL-1 beta when measured by their capacity to synergistically stimulate arachidonic acid metabolism of rat liver cells in the presence of palytoxin and anti-diuretic hormone (ADH). palytoxin 193-202 interleukin 1 beta Rattus norvegicus 55-65 3103171-4 1986 The rIL-1 alpha and rIL-1 beta also stimulated the release of radiolabelled arachidonic acid from the smooth muscle cells prelabelled with [3H]arachidonic acid. Arachidonic Acid 76-92 interleukin 1 beta Rattus norvegicus 20-30 3103171-4 1986 The rIL-1 alpha and rIL-1 beta also stimulated the release of radiolabelled arachidonic acid from the smooth muscle cells prelabelled with [3H]arachidonic acid. [3h]arachidonic acid 139-159 interleukin 1 beta Rattus norvegicus 20-30 30907158-10 2021 Treatment with GA remarkably improved SA-induced alteration of hematological and histopathological parameters; these protective effects were associated with the reduction of SA-induced elevation of MDA, IL-1beta and NO levels as well as reduction of GSH level and GPx, SOD and CAT activity. sodium arsenite 174-176 interleukin 1 beta Rattus norvegicus 203-211 33781876-8 2021 Mechanistically, LXT inhibited olanzapine-triggered hepatic over-phosphorylation of both IkappaB kinase (IKK)alpha/beta and nuclear factor (NF)kappaB p65 proteins, and mRNA overexpression of tumor necrosis factor alpha, interleukin 6, interleukin 1beta and CD68. Olanzapine 31-41 interleukin 1 beta Rattus norvegicus 235-252 33991607-5 2021 The results demonstrated that CDDO-Im treatment markedly improved the depressive-like behaviors and reduced neuronal cell loss in the hippocampus, through decreasing the malondialdehyde (MDA) content (indicative of lipid peroxidation), superoxide dismutase (SOD), NF-kB activation, interleukin-6 (IL-6) and interleukin-1b (IL-1beta) in PSD rats. 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole 30-37 interleukin 1 beta Rattus norvegicus 307-321 33704910-10 2021 Both TRI L and H doses decreased interleukin-1 beta and tumor necrosis factor-alpha (TNF-alpha). tri l 5-10 interleukin 1 beta Rattus norvegicus 33-51 33905870-4 2021 In Staphylococcus aureus infected rats, isoxanthanol treatment inhibited production of interleukin-18, interleukin-1beta and TNF-alpha significantly (P < 0.05) in the BALF and pulmonary tissues. [(2R,4R)-4-[(3aR,7S,8aS)-7-methyl-3-methylidene-2-oxo-4,7,8,8a-tetrahydro-3aH-cyclohepta[b]furan-6-yl]-4-hydroxybutan-2-yl] acetate 40-52 interleukin 1 beta Rattus norvegicus 103-120 34000276-0 2021 N-acetylserotonin alleviated the expression of interleukin-1beta in retinal ischemia-reperfusion rats via the TLR4/NF-kappaB/NLRP3 pathway. N-acetylserotonin 0-17 interleukin 1 beta Rattus norvegicus 47-64 34000276-1 2021 This study aimed to explore the effects of N-acetylserotonin (NAS) on the expression of interleukin-1beta (IL-1beta) in the retina of retinal ischemia-reperfusion injury (RIRI) rats via the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-kappaB)/nod-like receptor pyrin domain containing 3 (NLRP3) signaling pathway. N-acetylserotonin 43-60 interleukin 1 beta Rattus norvegicus 88-105 34000276-1 2021 This study aimed to explore the effects of N-acetylserotonin (NAS) on the expression of interleukin-1beta (IL-1beta) in the retina of retinal ischemia-reperfusion injury (RIRI) rats via the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-kappaB)/nod-like receptor pyrin domain containing 3 (NLRP3) signaling pathway. N-acetylserotonin 62-65 interleukin 1 beta Rattus norvegicus 88-105 34055003-13 2021 In addition, lycopene reduced levels of interleukin-1beta (IL-1beta) and interleukin-2 (IL-2) in VLG (P < 0.05), compared to NG. Lycopene 13-21 interleukin 1 beta Rattus norvegicus 40-57 33428483-6 2021 Also forced exercise in combination with TPM decreased malondialdehyde (MDA), tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) and Bax protein, while caused increase in superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) activities after PTZ administration. Topiramate 41-44 interleukin 1 beta Rattus norvegicus 122-140 33743341-8 2021 In addition, Vitamin B12 and its combination with LTG decreased levels of total oxidative status (TOS), oxidative stress index (OSI), interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and increased total antioxidant status (TAS) levels in the hippocampus and cerebral cortex. Vitamin B 12 13-24 interleukin 1 beta Rattus norvegicus 134-151 33743341-8 2021 In addition, Vitamin B12 and its combination with LTG decreased levels of total oxidative status (TOS), oxidative stress index (OSI), interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and increased total antioxidant status (TAS) levels in the hippocampus and cerebral cortex. Lamotrigine 50-53 interleukin 1 beta Rattus norvegicus 134-151 33835384-8 2021 As compared to the controls, STZ-injected rats showed significant elevations in the levels of blood glucose, tumor necrosis factor alfa, interleukin-1beta, malondialdehyde, nitric oxide, and expression levels of caspase-3 and B-cell lymphoma-2 associated X-protein. Streptozocin 29-32 interleukin 1 beta Rattus norvegicus 137-154 33932206-7 2021 The BPA group revealed significantly elevated IL-1B, IL-6, MDA and NO, and it showed significantly reduced IL-10, SOD, CAT and GSH when compared to the control and lycopene + BPA groups. bisphenol A 4-7 interleukin 1 beta Rattus norvegicus 46-51 33985878-7 2021 RESULTS: SAA significantly improved the degree of brain edema and ischemic area in I/R rats accompanied by decreases in levels of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha). salvianolic acid A 9-12 interleukin 1 beta Rattus norvegicus 130-147 33676175-9 2021 The enhanced activities of caspases -3 and -9 and cytokines: interleukin-1beta, and -6, and tumor necrosis factor-alpha) in the MCAO group were significantly protected with the treatment of 500 microg of NR. Asparaginyl-Arginine 204-206 interleukin 1 beta Rattus norvegicus 61-78 33610590-8 2021 The GLU + Abeta1-42 treatment significantly decreased cell viability, increased ROS formation, reduced superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities, augmented Advanced Glycation End Products- and 4-hydroxynonenal-adducts generation, increased 3-nitrotyrosine and inflammatory outcomes such as inducible nitric oxide synthase, interleukin 1beta and Tumor Necrosis Factor alpha, decreased MMP and augmented amyloid aggregation. Glucose 4-7 interleukin 1 beta Rattus norvegicus 373-390 33327798-5 2021 After renal I/R injury, high-salt diet significantly increased renal macrophage infiltration, inflammatory cytokines (tumor necrosis factor-alpha and interleukin 1 beta), systolic blood pressure, the urine/water intake ratio, plasma creatine and urea levels, urinary 8-isoprostane, and renal collagen deposition. Salts 29-33 interleukin 1 beta Rattus norvegicus 150-168 33827303-7 2021 Doxorubicin also increased reactive oxygen and nitrogen species, lipid peroxidation, pro-inflammatory-interleukin-1beta and tumour necrosis factor-alpha-cytokine, and apoptotic caspases-3 and -9). Doxorubicin 0-11 interleukin 1 beta Rattus norvegicus 102-119 33797720-8 2021 Moreover, benzene led to the activation of gene expression of the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and interleukin-6 (IL-6), a myelotoxicity in bone marrow cells. Benzene 10-17 interleukin 1 beta Rattus norvegicus 93-110 33141427-10 2021 Moreover, CdCl2 mediated inflammatory events in the cortical tissue through increasing tumor necrosis factor-alpha and interleukin-1 beta levels and upregulating the expression of inducible nitric oxide synthase. Cadmium Chloride 10-15 interleukin 1 beta Rattus norvegicus 119-137 33838246-8 2021 Moreover, EMB increased the level of inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1beta) and decreased brain-derived neurotrophic factor (BDNF) levels in rats" brains. emamectin benzoate 10-13 interleukin 1 beta Rattus norvegicus 93-110 33833854-0 2021 Acteoside Counteracts Interleukin-1beta-Induced Catabolic Processes through the Modulation of Mitogen-Activated Protein Kinases and the NFkappaB Cellular Signaling Pathway. acteoside 0-9 interleukin 1 beta Rattus norvegicus 22-39 33393059-10 2021 ECT alone increased interleukin-1beta (IL-1beta) and the administration of ketamine was able to revert this increase showing a neuroprotective effect of this drug when in combination with ECT. Ketamine 75-83 interleukin 1 beta Rattus norvegicus 20-37 33792028-9 2021 The results show that the atorvastatin treatment markedly increased survival rate, neurological score, greater survival of neurons, downregulated the protein expression of NLRP1, cleaved caspase-1, interleukin-1beta (IL-1beta), and IL-18, which indicated that atorvastatin-inhibited pyroptosis and neuroinflammation, ameliorated neuron death in vivo/vitro subjected to SAH. Atorvastatin 26-38 interleukin 1 beta Rattus norvegicus 198-215 33749080-11 2021 Daphnetin-treated rats showed a reduction of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta (IL-1beta), IL-2, IL-6, and inflammatory mediators including nuclear factor-kappaB. daphnetin 0-9 interleukin 1 beta Rattus norvegicus 109-126 33733385-7 2021 More importantly, F-LC-Lipo could improve the levels of interleukin-1 beta (IL-1beta), IL-6, malondialdehyde (MDA), superoxide dismutase (SOD), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), prostaglandin E2 (PEG2), and IL-10 in rats with enteritis. f-lc-lipo 18-27 interleukin 1 beta Rattus norvegicus 56-74 33731692-5 2021 Using rat insulinoma cells RINm5F and INS-1 treated with interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma), we demonstrate here that both rINGAP and Ingap-p inhibit apoptosis, Caspase-3 activation, inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production, and explore the related signaling pathways. ringap 150-156 interleukin 1 beta Rattus norvegicus 57-74 33731692-5 2021 Using rat insulinoma cells RINm5F and INS-1 treated with interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma), we demonstrate here that both rINGAP and Ingap-p inhibit apoptosis, Caspase-3 activation, inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production, and explore the related signaling pathways. ingap-p 161-168 interleukin 1 beta Rattus norvegicus 57-74 33755276-9 2021 Geraniin significantly (p < .001) decreased the level of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) pro-inflammatory cytokines. Geraniin 0-8 interleukin 1 beta Rattus norvegicus 98-115 33682914-9 2022 Meanwhile, berberine reversed elevated expression of cytokines interleukin-1beta and TNF-alpha in the serum and downregulated nuclear factor kappaB expression. Berberine 11-20 interleukin 1 beta Rattus norvegicus 63-80 33682265-6 2021 In the piriform cortex, NIMP significantly stimulated expression for the macrophage inflammatory proteins CCL4, IL-1A, and IL-1B. nimp 24-28 interleukin 1 beta Rattus norvegicus 123-128 34026086-7 2021 Moreover, 200 mg/kg BW ALA significantly decreased the hepatic levels of NLRP3 inflammasome activation-related proteins NLRP3, caspase-1, and interleukin-1beta expression by 40.0%, 60.1%, and 24.5%, respectively, in T2DM rats. Thioctic Acid 23-26 interleukin 1 beta Rattus norvegicus 142-159 33165014-10 2021 Immunohistochemistry revealed that the levels of inflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha were lowered with PBM treatment in both eyelid and conjunctiva. pbm 140-143 interleukin 1 beta Rattus norvegicus 72-89 33314588-6 2021 Mn alone and EtOH alone also increased neuro-inflammatory markers, namely nitric oxide, myeloperoxidase activity, interleukin-1beta, tumor necrosis factor-alpha, and nuclear factor-kappaB (NF-kappaB) levels in the cerebellar cortex. Ethanol 13-17 interleukin 1 beta Rattus norvegicus 114-131 33421931-7 2021 VPA exerted anti-inflammatory effects by downregulating proinflammatory cytokines (tumor necrosis factor-alpha, cytokines interleukin-1beta, cytokines interleukin-6; TNF-alpha, IL-1beta, and IL-6) and upregulating anti-inflammatory cytokines (transforming growth factor-beta, cytokines interleukin-10, cytokines interleukin-4; TGF-beta, IL-10 and IL-4). Valproic Acid 0-3 interleukin 1 beta Rattus norvegicus 122-139 33319922-8 2021 Additionally, GA treatment abrogated AFB1 -mediated decrease in interleukin-10 and elevation of inflammatory indices, namely tumor necrosis factor-alpha, myeloperoxidase activity, interleukin-1beta, and nitric oxide. Gallic Acid 14-16 interleukin 1 beta Rattus norvegicus 180-197 33562483-8 2021 Linalool enhanced cardiac antioxidant activities, reduced inflammatory cytokines (tumor necrosis factor-alpha (TNF-alpha), nuclear factor-kappa-B (NF-kappaB), interleukin 1 beta (IL-1beta), interleukin 6 (IL-6)), apoptotic markers (Caspase-3, Caspase-9, and Bax), and elevated Bcl2. linalool 0-8 interleukin 1 beta Rattus norvegicus 159-177 33665661-0 2021 [17beta-estradiol inhibits interleukin-1beta-induced rat nucleus pulposus cell apoptosis through the PI3K/Akt/mTOR signal pathway]. Estradiol 1-17 interleukin 1 beta Rattus norvegicus 27-44 33665661-2 2021 Our previous studies showed that 17beta-estradiol (E2) protects rat NPCs from interleukin-1beta (IL-1beta)-induced apoptosis via the PI3K/Akt signaling pathway. Estradiol 33-49 interleukin 1 beta Rattus norvegicus 78-95 33665661-2 2021 Our previous studies showed that 17beta-estradiol (E2) protects rat NPCs from interleukin-1beta (IL-1beta)-induced apoptosis via the PI3K/Akt signaling pathway. Estradiol 51-53 interleukin 1 beta Rattus norvegicus 78-95 33549629-9 2021 Similarly, treatment with 3HF suppressed the paclitaxel-induced increase in mRNA expression of several inflammatory cytokines including tumor necrosis factor -alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6), CGRP, and Substance P. However, the daily treatment of 3HF did not affect the motor behaviors of rats. 3-hydroxyflavone 26-29 interleukin 1 beta Rattus norvegicus 178-195 33549629-9 2021 Similarly, treatment with 3HF suppressed the paclitaxel-induced increase in mRNA expression of several inflammatory cytokines including tumor necrosis factor -alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6), CGRP, and Substance P. However, the daily treatment of 3HF did not affect the motor behaviors of rats. Paclitaxel 45-55 interleukin 1 beta Rattus norvegicus 178-195 33641344-6 2021 Rapamycin attenuated the increment in the expression of tumor necrosis factor-alpha and interleukin-1beta, the inducible nitric oxide synthase, gp91phox, and p47phox in addition to nitrite levels elicited by LPS in tissues or sera. Sirolimus 0-9 interleukin 1 beta Rattus norvegicus 88-105 33669305-4 2021 The body"s response to CS was evaluated by measuring body weight and the plasma level of plasma corticosterone (CORT), adrenocorticotropic hormone (ACTH), and interleukin 1 beta (IL1B). Cesium 23-25 interleukin 1 beta Rattus norvegicus 159-177 33669305-4 2021 The body"s response to CS was evaluated by measuring body weight and the plasma level of plasma corticosterone (CORT), adrenocorticotropic hormone (ACTH), and interleukin 1 beta (IL1B). Cesium 23-25 interleukin 1 beta Rattus norvegicus 179-183 33668480-4 2021 Evaluation of their ability to suppress the generation of PGE2 in interleukin-1beta plus forskolin-stimulated mesangial cells led to the identification of one alpha-ketobenzothiazole (GK181) and one alpha-ketobenzoxazole (GK491), which are able to suppress the PGE2 generation at a nanomolar level. Dinoprostone 58-62 interleukin 1 beta Rattus norvegicus 66-83 33668480-4 2021 Evaluation of their ability to suppress the generation of PGE2 in interleukin-1beta plus forskolin-stimulated mesangial cells led to the identification of one alpha-ketobenzothiazole (GK181) and one alpha-ketobenzoxazole (GK491), which are able to suppress the PGE2 generation at a nanomolar level. alpha-ketobenzothiazole 159-182 interleukin 1 beta Rattus norvegicus 66-83 33668480-4 2021 Evaluation of their ability to suppress the generation of PGE2 in interleukin-1beta plus forskolin-stimulated mesangial cells led to the identification of one alpha-ketobenzothiazole (GK181) and one alpha-ketobenzoxazole (GK491), which are able to suppress the PGE2 generation at a nanomolar level. gk181 184-189 interleukin 1 beta Rattus norvegicus 66-83 33659744-13 2021 Plasma interleukin-1beta concentration in the LPS and OLA groups was significantly higher than that in the CON group; however, there was no significant difference between the LPS and OLA groups. ola 54-57 interleukin 1 beta Rattus norvegicus 7-24 33523201-9 2021 In vitro study demonstrated that pinacidil inhibited tumor necrosis factor and interleukin-1beta expression in M1-type microglia and alleviated the M1 microglia-induced GFAP expression in the Muller cells. Pinacidil 33-42 interleukin 1 beta Rattus norvegicus 79-96 32579730-9 2021 Additionally, alcohol administration boosted lipid peroxidation and levels of glutathione in oxidized form (GSSG), tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta), and Bax protein; while decreased reducing type of glutathione (GSH), Bcl-2 protein, phosphorylated CREB and BDNF levels in rat hippocampus. Alcohols 14-21 interleukin 1 beta Rattus norvegicus 156-174 33491243-9 2021 CGA alleviated TAM-facilitated surges of reactive oxygen and nitrogen species, myeloperoxidase, nitric oxide, interleukin-1beta, and tumor necrosis factor-alpha in rats epididymis and testes. Tamoxifen 15-18 interleukin 1 beta Rattus norvegicus 110-127 33407653-8 2021 MiR-142 silence not only decreased the levels of proinflammatory mediators, such as interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha, but also increased the expressive levels of synaptic proteins including PSD95 and synapsin I in the hippocampus, which was one of the key brain regions associated with PTSD. mir-142 0-7 interleukin 1 beta Rattus norvegicus 84-101 33542790-9 2021 The levels of proinflammatory factors, such as interleukin-1beta and tumor necrosis factor-alpha, in kidney tissue and serum were also increased in the hyperuricemic rats, and resveratrol treatment inhibited their expression. Resveratrol 176-187 interleukin 1 beta Rattus norvegicus 47-64 33503985-8 2021 Nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3, interleukin-1beta, tumor necrosis factor-alpha, and cleaved caspase-1 were significantly downregulated in empagliflozin-treated and liraglutide-treated diabetic rats. empagliflozin 200-213 interleukin 1 beta Rattus norvegicus 94-111 33484196-2 2021 In the present study, we aimed to evaluate the functional mechanism of glycosides extracted from Caulis Lonicerae on the inflammatory proliferation of interleukin-1 beta (IL-1beta)-mediated fibroblast-like synoviocytes (FLSs) from rats. Glycosides 71-81 interleukin 1 beta Rattus norvegicus 151-169 33396140-8 2021 DEHA induced a significant increase in the serum levels of glucose, alanine transaminase, aspartate transaminase, acetylcholine esterase, creatine kinase-myocardium bound, malondialdehyde, tumor necrosis factor-alpha, and interleukin-1beta. dioctyl adipate 0-4 interleukin 1 beta Rattus norvegicus 222-239 33505502-4 2021 Besides, MSU remarkably elevated the release of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and IL-18; however, ZSD treatment dose dependently lowered these levels and resulted in a significant decrease in articular elastase activity. 6-[(8R)-2-({[(3,5-dimethyl-1,2-oxazol-4-yl)methyl](methyl)amino}methyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-5(4H)-yl]pyrimidin-4-amine 145-148 interleukin 1 beta Rattus norvegicus 89-106 33333050-6 2021 In addition, CYP induced marked increases in the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and nitric oxide (NO) confirmed by histological alterations. Cyclophosphamide 13-16 interleukin 1 beta Rattus norvegicus 100-117 33489777-8 2021 Results from this study revealed that GA significantly decreases serum hepatic enzymes, down-regulate the expression of pro-inflammatory cytokines, interleukin 1 beta (IL-1B), interleukin 6 (IL-6), cyclooxygenase 2 (COX 2), and tumor necrosis factor-alpha (TNF alpha), and up-regulate antioxidant gene expression (superoxide dismutase and catalase). Gallic Acid 38-40 interleukin 1 beta Rattus norvegicus 148-166 33489777-8 2021 Results from this study revealed that GA significantly decreases serum hepatic enzymes, down-regulate the expression of pro-inflammatory cytokines, interleukin 1 beta (IL-1B), interleukin 6 (IL-6), cyclooxygenase 2 (COX 2), and tumor necrosis factor-alpha (TNF alpha), and up-regulate antioxidant gene expression (superoxide dismutase and catalase). Gallic Acid 38-40 interleukin 1 beta Rattus norvegicus 168-173 33505502-4 2021 Besides, MSU remarkably elevated the release of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and IL-18; however, ZSD treatment dose dependently lowered these levels and resulted in a significant decrease in articular elastase activity. Uric Acid 9-12 interleukin 1 beta Rattus norvegicus 89-106 33995926-8 2021 Moreover, paeonol significantly restored striatal malondialdehyde, tissue levels of reactive oxygen species, the activity of the protective and vital enzymes consisting of superoxide dismutase and catalase, Glial Fibrillary Acidic Protein (GFAP), DNA fragmentation, phosphor apoptosis signal-regulating kinase 1, and nigral aquaporin 4 with no significant and proper change of nitrite, interleukin-1beta, inducible nitric oxide synthase, and angiotensin II. paeonol 10-17 interleukin 1 beta Rattus norvegicus 386-403 33147650-4 2021 In this study, we found that beta-carotene significantly reduced (p < .05) the production of nitric oxide (NO), prostaglandin (PG)E2, tumor necrosis factor (TNF)-alpha, and interleukin-1beta (IL-1beta) levels by the Griess reaction and enzyme-linked immunosorbent assay (ELISA), and we found that beta-carotene significantly suppressed (p < .05) the mRNA expression levels of IL-1beta and TNF-alpha by RT-PCR. beta Carotene 29-42 interleukin 1 beta Rattus norvegicus 173-190 33139224-7 2021 Rats treated with LZS ointment experienced significantly ameliorated Evans blue extravasation (P < 0.05), decreased macroscopic severity score (0.86 +- 0.14 vs. 1.65 +- 0.16) and the anorectal coefficient (P < 0.01); its use also attenuated tissue damage and inhibited the expression and secretion levels of inflammation-related cytokines (interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha). N-{6-(Cyclopropylmethoxy)-7-Methoxy-2-[6-(2-Methylpropyl)-5-Oxo-3,4,5,6-Tetrahydro-2,6-Naphthyridin-2(1h)-Yl]quinazolin-4-Yl}-2,2,2-Trifluoroethanesulfonamide 18-21 interleukin 1 beta Rattus norvegicus 340-357 32767013-5 2020 The co-administration of Vit E and CLO significantly ameliorated CP-induced elevations in serum creatinine (Cr), blood urea nitrogen (BUN), interleukin 1 beta (IL-1beta), and interleukin- 6 (IL-6). Cod Liver Oil 35-38 interleukin 1 beta Rattus norvegicus 140-158 32967526-11 2021 However, there was marked increase in the uterine MDA and interleukin 1b levels, with concurrent decrease in SOD and GSH activities, in the EB-treated group, which was significantly reversed by MP co-administration. Eriochrome Blue SE 140-142 interleukin 1 beta Rattus norvegicus 58-72 32967526-11 2021 However, there was marked increase in the uterine MDA and interleukin 1b levels, with concurrent decrease in SOD and GSH activities, in the EB-treated group, which was significantly reversed by MP co-administration. 6-trimethylsilylthio-9-trimethylsilylpurine 194-196 interleukin 1 beta Rattus norvegicus 58-72 32967526-13 2021 The immunoexpression of ERalpha and IL-1b in the EB-treated group was reversed by MP co-administration. 6-trimethylsilylthio-9-trimethylsilylpurine 82-84 interleukin 1 beta Rattus norvegicus 36-41 33408612-5 2020 MiR-125b inhibition facilitated neurite outgrowth but suppressed cell apoptosis and proinflammatory cytokines (tumor necrosis factor-alpha, interleukin 1beta, and interleukin 6); meanwhile, it upregulated FOXQ1 but downregulated PTGS2 and CDK5. mir-125b 0-8 interleukin 1 beta Rattus norvegicus 140-157 32971212-8 2020 In addition, AlCl3 exposure increased the levels of malondialdehyde (MDA) and 8-hydroxy-2"-deoxyguanosine (8-OHdG) and the levels of interleukin-1 beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the HP and the FC. Aluminum Chloride 13-18 interleukin 1 beta Rattus norvegicus 133-151 31312872-7 2020 RESULTS: Alprostadil increased the cell viability of LPS-stimulated H9c2 cells, reduced LDH and troponin production, and attenuated IL-1beta, IL-6, IL-17, and TNF-alpha secretion. Alprostadil 9-20 interleukin 1 beta Rattus norvegicus 132-140 31853804-10 2020 Additionally, vildagliptin significantly increased the expression of genes PGC-1alpha, SIRT-1, and NRF-2 and reduced the levels of myeloperoxidase, creatine kinase release, and myocardial content of TNF-alpha and IL-1beta in nondiabetic and diabetic rats as compared to corresponding controls (P < 0.01-0.05). vildagliptin 14-26 interleukin 1 beta Rattus norvegicus 213-221 32485303-13 2020 CBBP also significantly suppressed the expression of interleukin -1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), nuclear factor kappa B (NF-kappaB), and brain-derived neurotrophic factor (BDNF) and its TrkB receptors, and improved the expression of GABA type A receptors (GABAAR) and farnesoid X receptors (FXR). phosphon 0-4 interleukin 1 beta Rattus norvegicus 53-71 33047361-5 2020 Testicular inflammation was evident indicated by increased levels of interleukin-1beta and tumor necrosis factor-alpha in CdCl2 -treated rats. Cadmium Chloride 122-127 interleukin 1 beta Rattus norvegicus 69-86 33312127-9 2020 Further biochemical analyses showed that irisin inhibited SCI-induced overexpression of Interleukin-1beta (IL-1beta), Interleukin- 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), inducible nitricoxidesynthase (iNOS) and Cyclooxygenase-2 (COX-2)], as well as nuclear factor kappa-B (NF-kappaB)p65 in rats, and the positive function of irisin could be reversed by Compound C treatment. irisin 41-47 interleukin 1 beta Rattus norvegicus 88-105 33047770-9 2020 Most importantly, post treatment with astaxanthin decreased the increasing of inflammatory cytokine NF-kappaB, tumor necrosis factor-alpha, interleukin-1beta, oxidative stress level, and total arsenic content in livers of rats exposed to arsenic. astaxanthine 38-49 interleukin 1 beta Rattus norvegicus 140-157 33111549-0 2021 Blockade of Fgfr1 with PD166866 Protects Cartilage from the Catabolic Effects Induced by Interleukin-1beta: A Genome-Wide Expression Profiles Analysis. PD 166866 23-31 interleukin 1 beta Rattus norvegicus 89-106 33111549-2 2021 The aim of this study is to evaluate the effect of PD166866, a potent selective inhibitor of Fgfr1, on cartilage degeneration induced by interleukin-1beta (IL-1beta) and to clarify underlying global gene expression pattern. PD 166866 51-59 interleukin 1 beta Rattus norvegicus 137-154 33086604-11 2020 Lead acetate increased the serum levels of alanine and aspartate aminotransferases and that of urea, creatinine, tumor necrosis factor alpha, and interleukin 1beta, hepatic tissue malondialdehyde contents, and caspase 3 protein expression, as well as altering the hepatic tissue architecture. lead acetate 0-12 interleukin 1 beta Rattus norvegicus 146-163 33081801-9 2020 We found that intrathecal administration of resveratrol (300ug/day) alleviated mechanical allodynia; obviously enhanced autophagy; and markedly reduced the levels of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in the ipsilateral spinal dorsal horn after SNI. Resveratrol 44-55 interleukin 1 beta Rattus norvegicus 166-183 33194013-7 2020 Additionally, interleukin 1beta (IL-1beta), a pro-inflammatory cytokine released by activated glia was significantly up-regulated in the A1 cortex and MGB of rats after salicylate treatments. Salicylates 169-179 interleukin 1 beta Rattus norvegicus 14-31 33069202-7 2021 Injection of STZ resulted in a decline in the insulin, high density lipoprotein and body weight values matched with increase of glucose, total cholesterol, LDL-Cholesterol, triglycerides and interleukin1- beta (IL-1beta). Streptozocin 13-16 interleukin 1 beta Rattus norvegicus 191-209 32798558-9 2020 Results from rats demonstrated that treatment with Dex reversed the increased inflammatory cells in lung and the increased levels of TNF-alpha, interleukin-1beta (IL-beta), MCP-1 and chemokine (C-X-C motif) ligand 1 (CXCL1) resulted from non-ventilation; Dex increased the anti-inflammatory cytokine interleukin-10 (IL-10) in BALF from non-ventilated lung. Dexmedetomidine 51-54 interleukin 1 beta Rattus norvegicus 144-161 33146290-10 2020 Interestingly, direct injection of adenosine A1 or substance P receptor antagonists, or dorsal nerve root transection could significantly impair electroacupuncture induced analgesic actions in Complete Freund"s Adjuvant rats could and reduce the levels of substance P, neurokinin-1 receptor, tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and CD68. Adenosine 35-44 interleukin 1 beta Rattus norvegicus 321-338 32846221-8 2020 Results from RT-qPCR showed up-regulation of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) after 2-VO. 2-vo 124-128 interleukin 1 beta Rattus norvegicus 89-106 31916291-7 2020 Furthermore, PKM2 silencing protected chondrocytes against IL-1beta-triggered inflammatory response, as reflected by the downregulated release of proinflammatory mediators, including tumor necrosis factor-alpha, IL-6, inducible nitric oxide synthase, cyclooxygenase-2, and prostaglandin E2, as well as decreased nitric oxide generation. Dinoprostone 273-289 interleukin 1 beta Rattus norvegicus 59-67 32418004-10 2020 Baicalein significantly (p < 0.001) ameliorated the infarction volume, brain water content, and neurological outcome, and the malondialdehyde level, and reduced the level of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, superoxide dismutase, glutathione, and catalase in a dose-dependent manner. baicalein 0-9 interleukin 1 beta Rattus norvegicus 174-191 32608003-10 2020 Acrylamide intoxication was associated with significant (p < 0.05) increases in serum levels of liver injury biomarkers (alanine transferase, aspartate transferase, and alkaline phosphatase), renal function products (urea, creatinine), DNA oxidative damage biomarker (8-oxo-2"-deoxyguanosine), and pro-inflammatory biomarkers (interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha). Acrylamide 0-10 interleukin 1 beta Rattus norvegicus 327-344 32748670-8 2020 In addition, TQ suppressed the inflammation reaction parameters (interleukin-1beta and -6, IL-1beta and IL-6; tumor necrosis factor-alpha, TNF-alpha) and oxidative stress in PM2.5-induced lung injury. thymoquinone 13-15 interleukin 1 beta Rattus norvegicus 65-89 32347117-9 2020 The levels of serum cytokines (tumor necrosis factor-alpha and interleukin-1 beta) and liver injury marker enzymes (alanine aminotransferase and aspartate aminotransferase) significantly increased in the rat dams treated with ZnO-NPs (25 and 50 mg kg-1) and their offsprings. zno-nps 226-233 interleukin 1 beta Rattus norvegicus 63-81 31916291-7 2020 Furthermore, PKM2 silencing protected chondrocytes against IL-1beta-triggered inflammatory response, as reflected by the downregulated release of proinflammatory mediators, including tumor necrosis factor-alpha, IL-6, inducible nitric oxide synthase, cyclooxygenase-2, and prostaglandin E2, as well as decreased nitric oxide generation. Nitric Oxide 228-240 interleukin 1 beta Rattus norvegicus 59-67 31916291-7 2020 Furthermore, PKM2 silencing protected chondrocytes against IL-1beta-triggered inflammatory response, as reflected by the downregulated release of proinflammatory mediators, including tumor necrosis factor-alpha, IL-6, inducible nitric oxide synthase, cyclooxygenase-2, and prostaglandin E2, as well as decreased nitric oxide generation. Nitric Oxide 312-324 interleukin 1 beta Rattus norvegicus 59-67 32984584-13 2020 Vitamin D diet significantly (p < 0.05) reduced the level of interleukin 1beta and TNF-alpha produced in the deficiency state. Vitamin D 0-9 interleukin 1 beta Rattus norvegicus 61-78 32246641-11 2020 L-cysteine inhibited microglial activation in the prefrontal cortex and reduced the mRNA levels of interleukin 1beta and CD86. Cysteine 0-10 interleukin 1 beta Rattus norvegicus 99-116 32992548-6 2020 Furthermore, MG reduced plasma interleukin-1beta (IL-1beta) and protein expression of NLR family pyrin domain-containing 3 (NLRP3), apoptosis-associated speck-like protein (ASC), and caspase 1 as well as upregulated nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and induction of heme oxygenase-1 (HO-1) in hepatocytes of Tylo-treated rats. magnolol 13-15 interleukin 1 beta Rattus norvegicus 31-48 32619679-7 2020 in fructose-fed rats by down-regulating mRNA and protein levels of nicotinamide adenine dinucleotide phosphate oxidase (NOX) 1, NOX2 and NOX4, resulting in reduction of interleukin-1beta (IL-1beta) levels (1.13 +- 0.09 a.u. Fructose 3-11 interleukin 1 beta Rattus norvegicus 169-186 32932753-5 2020 Moreover, AlCl3 significantly increased tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and acetylcholinesterase (AChE) activities. Aluminum Chloride 10-15 interleukin 1 beta Rattus norvegicus 81-98 31526851-10 2020 MiR-101 mimics inhibited LPS-stimulated increase in the levels of IL-6, IL-1beta and TNF-alpha in primary microglial cells in vitro. mir-101 0-7 interleukin 1 beta Rattus norvegicus 72-80 32615180-8 2020 O-1602 also reversed the pro-inflammatory activity of CYP by restoring concentrations of brain-derived neurotrophic factor, nerve growth factor, calcitonin gene related peptide, interleukin 1-beta, interleukin-6, tumour necrosis factor alpha, malondialdehyde, nitrotyrosine, occludin, and organic cation transporter 3. O-1602 0-6 interleukin 1 beta Rattus norvegicus 178-196 32765751-6 2020 Prazosin treatment decreased the serum expression levels of the inflammatory factors, interleukin-1beta and tumor necrosis factor-alpha in rats with cerebral infarctions as well as in EPCs in vitro. Prazosin 0-8 interleukin 1 beta Rattus norvegicus 86-103 32295429-10 2020 Aspirin induced elevation in the inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta. Aspirin 0-7 interleukin 1 beta Rattus norvegicus 112-129 32585605-9 2020 In addition, curcumin, but not hesperidin, decreased interleukin-1beta (IL-1beta) and MDA levels. Curcumin 13-21 interleukin 1 beta Rattus norvegicus 53-70 32614079-6 2020 When CR groups compared to sepsis group, CR significantly decreased the serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT), interleukin-1 beta (IL-1beta), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and levels of malondialdehyde (MDA) in tissues. chrysin 41-43 interleukin 1 beta Rattus norvegicus 153-171 31526851-11 2020 In the rat CCI model, miR-101 mimics also suppressed CCI-induced decrease in PWT and PWL and inhibited CCI-induced increase in mRNA and protein levels of IL-6, IL-1beta and TNF-alpha. mir-101 22-29 interleukin 1 beta Rattus norvegicus 160-168 33832914-2 2020 We aimed to determine the antiepileptic potential of phyto-flavonoids on the evaluation of the mRNA expression of TNF-alpha, IL-6, IL-1 Beta, IL-10, IL-1Ra, IL 4 and NF-kappaB. phyto-flavonoids 53-69 interleukin 1 beta Rattus norvegicus 131-140 32882253-7 2021 Neferine markedly lowered the upregulated P2 x 3 receptor and interleukin-1beta, inhibited the phosphorylation and activation of ERK1/2 in the DRGs of CCI rats, and relieved neuropathic pain. neferine 0-8 interleukin 1 beta Rattus norvegicus 62-79 32569423-8 2020 Further study found that pirfenidone suppressed the expression of proinflammatory mediators, including tumor necrosis factor-alpha, interleukin-1beta (IL-1beta), IL-6, IL-8. pirfenidone 25-36 interleukin 1 beta Rattus norvegicus 132-149 32758512-8 2020 PCA effectively mitigated furan-mediated increases in myeloperoxidase activity, levels of reactive oxygen and nitrogen species, nitric oxide, tumour necrosis factor-alpha, and interleukin-1beta in testes, epididymis, and hypothalamus of rats. furan 26-31 interleukin 1 beta Rattus norvegicus 176-193 32336744-8 2020 The results showed that treatment of schisandrin significantly reduced the production of inflammation mediators including tumor necrosis factor-alpha, interleukin-1beta and interleukin-6. schizandrin 37-48 interleukin 1 beta Rattus norvegicus 151-168 32879619-6 2020 MCL also prevented LPS- and adenosine triphosphate-induced NLRP3 inflammasome activation in vitro, as evidenced by the inhibition of NLRP3 expression, caspase-1 cleavage, and interleukin-1beta and interleukin-18 maturation and secretion. Adenosine 28-37 interleukin 1 beta Rattus norvegicus 175-192 32782444-6 2020 Compared to untreated rat, Emo-treated rat exhibited significantly ameliorated lung pathological changes and decreased tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). Emodin 27-30 interleukin 1 beta Rattus norvegicus 163-180 32781857-5 2022 The anti-inflammatory effect of zingerone was determined by measuring the cytokine levels causing inflammation such as nuclear factor-kappa B (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta), and its effects on apoptosis were determined by immunohistochemical analysis of caspase-3 and B-cell lymphoma-2 (Bcl-2) expression levels. zingerone 32-41 interleukin 1 beta Rattus norvegicus 200-217 32831633-7 2020 Moreover, inhibition of the ROS-EGFR pathway with Nox1/4 inhibitor GKT137831 or selective EGFR inhibitor AG1478 reduced protein and mRNA levels of proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and interleukin 1beta (IL-1beta), as well as the activities of Akt and extracellular signal-regulated kinase (ERK) 1/2 in the left ventricle of SHRs. Reactive Oxygen Species 28-31 interleukin 1 beta Rattus norvegicus 240-257 32831633-7 2020 Moreover, inhibition of the ROS-EGFR pathway with Nox1/4 inhibitor GKT137831 or selective EGFR inhibitor AG1478 reduced protein and mRNA levels of proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and interleukin 1beta (IL-1beta), as well as the activities of Akt and extracellular signal-regulated kinase (ERK) 1/2 in the left ventricle of SHRs. setanaxib 67-76 interleukin 1 beta Rattus norvegicus 240-257 32831633-7 2020 Moreover, inhibition of the ROS-EGFR pathway with Nox1/4 inhibitor GKT137831 or selective EGFR inhibitor AG1478 reduced protein and mRNA levels of proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and interleukin 1beta (IL-1beta), as well as the activities of Akt and extracellular signal-regulated kinase (ERK) 1/2 in the left ventricle of SHRs. RTKI cpd 105-111 interleukin 1 beta Rattus norvegicus 240-257 32627010-6 2020 Furthermore, TAK-242 decreased the protein expression levels of TLR4, MyD88, TIR-domain-containing adapter-inducing interferon-beta (TRIF), NF-kappaB, tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta in the hippocampus. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 13-20 interleukin 1 beta Rattus norvegicus 195-212 32279160-0 2020 Suberoylanilide Hydroxamic Acid Attenuates Interleukin-1beta-Induced Interleukin-6 Upregulation by Inhibiting the Microtubule Affinity-Regulating Kinase 4/Nuclear Factor-kappaB Pathway in Synovium-Derived Mesenchymal Stem Cells from the Temporomandibular Joint. Vorinostat 0-31 interleukin 1 beta Rattus norvegicus 43-60 32506379-9 2020 Arbutin decreased inflammatory cytokines (IL-1B, IL-17, TNF-alpha) and iNOS mRNA expression level. Arbutin 0-7 interleukin 1 beta Rattus norvegicus 42-47 32859881-8 2020 The results showed that RSV administration reduced plasma levels of aminotransferases and proinflammatory cytokines including interleukin-1 beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) in HCFD-induced NAFLD. Resveratrol 24-27 interleukin 1 beta Rattus norvegicus 126-144 32751448-8 2020 ASBE treatment also reduced Cyclooxygenase-2 (COX-2), Prostaglandin E2 (PGE2) & Interleukin-1beta (IL-1beta) levels in the inflamed colon. asbe 0-4 interleukin 1 beta Rattus norvegicus 80-97 32722564-4 2020 GW501516 strongly suppressed infiltration of neutrophils and pan-macrophages, and reduced the mRNA expression of interleukin-6, interleukin-1beta, tumor necrosis factor alpha, and nuclear factor-kappa B. GW 501516 0-8 interleukin 1 beta Rattus norvegicus 128-145 32715125-10 2020 Oral pretreatment with thymol increased reduced glutathione (GSH), reduced malondialdehyde (MDA), nuclear factor-kappa B (NF-kappaB), and interleukin-1beta (IL-1beta) cardiac contents in MI rats. Thymol 23-29 interleukin 1 beta Rattus norvegicus 138-155 32733956-9 2020 Inhibition of P2X7R with Brilliant Blue G (BBG) reversed neuropathic pain might decrease through the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 via inhibiting p38MAPK phosphorylation. coomassie Brilliant Blue 25-41 interleukin 1 beta Rattus norvegicus 156-173 32733956-9 2020 Inhibition of P2X7R with Brilliant Blue G (BBG) reversed neuropathic pain might decrease through the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 via inhibiting p38MAPK phosphorylation. coomassie Brilliant Blue 43-46 interleukin 1 beta Rattus norvegicus 156-173 32627270-6 2020 Furthermore, DOX-induced rats showed augmented inflammatory mediators (nuclear factor-kappaB [NF-kB], tumor necrosis factor-alpha [TNF-alpha], and interleukin-1beta [IL-1beta]) and increased PI3K/Akt signaling proteins (PI3K, p-Bad/Bad, caspase-3, and p-Akt), whereas decreased oxidative markers (HO-1 and NQO-1) and p-PTEN were observed. Doxorubicin 13-16 interleukin 1 beta Rattus norvegicus 147-164 32628132-5 2020 Pretreating primary chondrocytes with tomatidine suppressed interleukin-1beta (IL-1beta)-induced expression of iNOS, COX-2, MMP1, MMP3, MMP13, and ADAMTS-5. tomatidine 38-48 interleukin 1 beta Rattus norvegicus 60-77 33335763-8 2020 SSa pretreatment significantly reduced the serum HMGB1 level and downregulated the contents of inflammatory cytokines including tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6. saikosaponin D 0-3 interleukin 1 beta Rattus norvegicus 157-175 33078731-7 2020 Pro inflammatory mediators (tumor necrosis factor-alpha TNF-alpha and interleukin-1beta) were noted to increase in the hippocampus and striatum of QA-treated rats. Quinolinic Acid 147-149 interleukin 1 beta Rattus norvegicus 70-87 32222576-7 2020 The flavonoid-enriched extract (FEE) inhibited xylene-induced mouse ear edema and cotton ball-induced rat granuloma, and suppressed LPS-induced over-release and/or overexpression of tumor necrosis factor-alpha, cyclooxygenase-2, inducible nitric oxide synthase, interleukin-1beta and interleukin-6 in RAW264.7 macrophages. Flavonoids 4-13 interleukin 1 beta Rattus norvegicus 262-279 31446563-12 2020 Additionally, serum levels and kidney mRNA expressions of TNF-alpha, NFkappaB, IL-1beta, and IFN-gamma were found to be the highest in the gentamicin group. Gentamicins 139-149 interleukin 1 beta Rattus norvegicus 79-87 32392679-9 2020 PCA also prevented the Cd-induced inflammation by reducing the pro-inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-1beta. Cadmium 23-25 interleukin 1 beta Rattus norvegicus 133-150 32427711-4 2020 Besides, monascin decreased the levels of pro-inflammatory factors such as interleukin-1beta, interleukin-6, tumor necrosis factor-alpha and oxidative stress marker malondialdehyde while promoted the expression of superoxide dismutase, glutathione peroxidase and other antioxidant factors. monascin 9-17 interleukin 1 beta Rattus norvegicus 75-92 32126269-8 2020 Hepatocytes exposed to FFA and CoCl2 exhibited increased TG content and higher cell death rates as well as increased mitochondrial superoxide production and mRNA levels of pro-inflammatory cytokines and of inflammasome-components interleukin-1beta, NLRP3 and ASC. cobaltous chloride 31-36 interleukin 1 beta Rattus norvegicus 230-247 31401744-0 2020 Diacerein Downregulates NLRP3/Caspase-1/IL-1beta and IL-6/STAT3 Pathways of Inflammation and Apoptosis in a Rat Model of Cadmium Testicular Toxicity. diacerein 0-9 interleukin 1 beta Rattus norvegicus 40-48 31201489-5 2020 RESULTS: Chronic DEX treatment significantly (P < 0.05) decreased serum corticosterone level and increased proinflammatory cytokines, such as TNFalpha, IL-1beta, and IL-6. Dexamethasone 17-20 interleukin 1 beta Rattus norvegicus 155-163 31401744-5 2020 Cadmium significantly declined serum testosterone and significantly raised interleukin-1beta, interleukin-6, interleukin-18, tumor necrosis factor-alpha, caspase-1, phosphorylated signal transducer and activator of transcription-3 (pSTAT3), nuclear factor-kappaB p65, Bax, and caspase-3 in rat testes. Cadmium 0-7 interleukin 1 beta Rattus norvegicus 75-92 31401744-8 2020 It was concluded that DCN significantly protected the gonads of male rats exposed to cadmium toxicity through modulation of NLRP3/caspase-1/IL-1beta and IL-6/STAT3 pathways of inflammation and apoptosis. diacerein 22-25 interleukin 1 beta Rattus norvegicus 140-148 32056223-7 2020 Furthermore, the numbers of synovial CD3+ or CD68+ inflammatory cells were reduced, and the elevated levels of tumour necrosis factor-alpha, interleukin-1beta (IL-1beta) and IL-6 were restored to control levels by the Evo treatment. evodiamine 218-221 interleukin 1 beta Rattus norvegicus 141-158 31863333-10 2020 Histamine was able to induce microglia activation and subsequent production of the inflammatory factors TNF-alpha, IL-1beta and IL-10, and these effects were partially abolished by H1R and H4R antagonists. Histamine 0-9 interleukin 1 beta Rattus norvegicus 115-123 31863333-14 2020 Graphical Abstract Histamine induces microglia activation and the release of both proinflammatory (TNF-alpha and IL-1beta) and anti-inflammatory factors (IL-10) in rat brain, thus contributing to the development of inflammation in the brain. Histamine 19-28 interleukin 1 beta Rattus norvegicus 113-121 33077694-9 2020 In addition, warfarin led to an earlier decrease in serum concentration of pro-inflammatory interleukin-1beta and plasma level of D-dimer. Warfarin 13-21 interleukin 1 beta Rattus norvegicus 92-109 31811327-7 2020 Further experiment indicated that SAL treatment reduced inflammatory factors such as IL-1beta, IL-6, and TNF-alpha and decreased tunnel-positive cells and pro-apoptotic Bax after MI. seryl-alanyl-leucy-leucyl-arginyl-seryl-isoleucyl-prolyl-alanine 34-37 interleukin 1 beta Rattus norvegicus 85-93 31483061-6 2020 PBM treatment resulted in reduction of exaggerated inflammatory responses evident by significantly repressed levels of interleukin-1beta (IL-1beta), IL-6, cyclooxygenase 2 (COX-2), and substance-P receptor (SPR), as well as inhibited apoptotic cell death by decreasing p53, cytochrome C, and caspase 3 levels (P < 0.05), which, in turn, effectively augment the wound repair in immunosuppressed rats. pbm 0-3 interleukin 1 beta Rattus norvegicus 119-136 31483061-6 2020 PBM treatment resulted in reduction of exaggerated inflammatory responses evident by significantly repressed levels of interleukin-1beta (IL-1beta), IL-6, cyclooxygenase 2 (COX-2), and substance-P receptor (SPR), as well as inhibited apoptotic cell death by decreasing p53, cytochrome C, and caspase 3 levels (P < 0.05), which, in turn, effectively augment the wound repair in immunosuppressed rats. pbm 0-3 interleukin 1 beta Rattus norvegicus 138-146 32387616-5 2020 In experimental periodontitis sites, SIM-DOX nanospheres significantly down-regulated IL-1b and MMP-8 and significantly reduced bone loss. sim-dox 37-44 interleukin 1 beta Rattus norvegicus 86-91 31758388-8 2020 As results, TPM administration improved the spatial learning and memory ability in POCD rat by decreasing the expression levels of Fas, FADD, and inflammatory factors (tumor necrosis factor-alpha, TNF-alpha; interleukin-1beta, IL-1beta; interleukin-6, IL-6) in POCD rats. topiramate 12-15 interleukin 1 beta Rattus norvegicus 208-225 31758388-8 2020 As results, TPM administration improved the spatial learning and memory ability in POCD rat by decreasing the expression levels of Fas, FADD, and inflammatory factors (tumor necrosis factor-alpha, TNF-alpha; interleukin-1beta, IL-1beta; interleukin-6, IL-6) in POCD rats. topiramate 12-15 interleukin 1 beta Rattus norvegicus 227-235 32485857-5 2020 beta-funaltrexamine shifted the polarization of microglia towards the anti-inflammatory phenotype, as evidenced by decreased nitric oxide, tumor necrosis factor-alpha, interleukin-1beta, and prostaglandin E2, along with increased CD163 and arginase 1. beta-funaltrexamine 0-19 interleukin 1 beta Rattus norvegicus 168-185 32198107-12 2020 In addition, nicotine treatment increased lipid peroxidation and the levels of oxidized form of glutathione (GSSG), interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and Bax protein, while decreasing reduced form of glutathione (GSH), Bcl-2 protein, P-CREB and BDNF levels in the hippocampus of experimental animals. Nicotine 13-21 interleukin 1 beta Rattus norvegicus 116-134 32546959-9 2020 Crocetin was found to significantly restore the protein levels of interleukin 6 (IL-6), interleukin 1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha). crocetin 0-8 interleukin 1 beta Rattus norvegicus 88-105 31792810-7 2020 Meanwhile, scutellarin suppressed the expression of proinflammatory mediators including iNOS, TNF-alpha, and IL-1beta in AM/BM. scutellarin 11-22 interleukin 1 beta Rattus norvegicus 109-117 32486412-9 2020 Treatment with ICTA significantly attenuated the carrageenan-induced hyperalgesia and reduced the elevated levels of proteins including TNF-a and IL-1b in the rats. icta 15-19 interleukin 1 beta Rattus norvegicus 146-151 32531700-7 2020 RESULTS: Compared with sham rats, elevated level of proinflammatory interleukin-1beta (IL-1beta) in plasma, neurological function deficit, reduced glucose uptake in ipsilateral hemisphere, obvious infarct size, the activation of NLRP3 inflammasomes and enhanced microglial pyroptosis were presented in MCAO rats. Glucose 147-154 interleukin 1 beta Rattus norvegicus 68-85 31808807-8 2020 Additionally, CN significantly reduced the burn-induced increases in Interleukin-1beta, Growth-Regulated Oncogene/Keratinocyte Chemoattractant, and Macrophage Inflammatory Protein-1alpha in burn wounds. cerium nitrate 14-16 interleukin 1 beta Rattus norvegicus 69-86 31880092-9 2020 Furthermore, lycopene was suggested to reduce the levels of chemokines MCP1 and MIP-1alpha, down-regulate the expression levels of cytokines (such as TNFalpha, IL-1beta, IL-2, and IL-6), and up-regulate those of CAT, GSH-PX and T-SOD,decrease that of MDA. lycopene 13-21 interleukin 1 beta Rattus norvegicus 160-168 31883121-9 2020 Anti-VEGF additionally reversed the upregulation of VEGF-A, VEGF-R2, HIF-1alpha, MCP-1 and VCAM-1, whereas R-954 inhibited gene expression of IL-1beta and COX-2. Ac-Orn-(Oic2, alpha-MePhe5, D-betaNal7, Ile8)desArg9-bradykinin 107-112 interleukin 1 beta Rattus norvegicus 142-150 32742598-8 2020 Methamphetamine administration may improve malondialdehyde, tumor necrosis factor-alpha, interleukin-1 beta and GSK3 (both forms). Methamphetamine 0-15 interleukin 1 beta Rattus norvegicus 89-107 32419805-6 2020 QUER administration significantly reduced inflammatory markers such as interleukin-6, interleukin-1beta, cyclooxygenase-2, and nuclear factor-kappaB levels in the brain. Quercetin 0-4 interleukin 1 beta Rattus norvegicus 86-103 32392916-3 2020 Furthermore, the production of 25-HC increased in the chondrocytes treated with interleukin-1beta through the expression of CH25H. 25-hydroxycholesterol 31-36 interleukin 1 beta Rattus norvegicus 80-97 32395076-3 2020 Furthermore, the production of 25-HC increased in the chondrocytes treated with interleukin-1beta through the expression of CH25H. 25-hydroxycholesterol 31-36 interleukin 1 beta Rattus norvegicus 80-97 32130432-5 2020 Moreover, ifenprodil activated mTOR signaling and reversed the CUMS-induced elevation of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in the hippocampus after acute administration. ifenprodil 10-20 interleukin 1 beta Rattus norvegicus 89-106 32130432-14 2020 Moreover, ifenprodil reversed the CUMS-induced elevation of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in the hippocampus after acute administration. ifenprodil 10-20 interleukin 1 beta Rattus norvegicus 60-77 32382283-6 2020 The treatment of hordenine restored estradiol, induced the overgrowth of pituitary gland, and reduced the prolactin (PRL) accumulation in the serum and pituitary gland of rats by blocking the MAPK (p38, ERK1/2, and JNK) activation and production of inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6). hordenine 17-26 interleukin 1 beta Rattus norvegicus 314-331 31264127-8 2020 Glycerol-injected rats showed a significant increase in the kidney relative weight, as well as in the serum urea, creatinine, Kim-1, and renal malondialdehyde, nitric oxide, TNF-alpha, IL-1beta, cytochrome c, Bax, and caspase-3 levels. Glycerol 0-8 interleukin 1 beta Rattus norvegicus 185-193 31958453-0 2020 Protective effects of Erdosteine on interleukin-1beta-stimulated inflammation via inhibiting the activation of MAPK, NF-kappaB, and Wnt/beta-catenin signaling pathways in rat osteoarthritis. erdosteine 22-32 interleukin 1 beta Rattus norvegicus 36-53 31881187-2 2020 Doxorubicin has been shown to cause overexpression of proinflammatory cytokines including MCP-1 and IL-1beta via activation of the NF-kappaB pathway. Doxorubicin 0-11 interleukin 1 beta Rattus norvegicus 100-108 31994228-7 2020 Maternal administration of LiCl disturbed the levels of neonatal serum tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), interleukin-1 beta (IL-1beta), interferon-gamma (INF-gamma), leptin, adiponectin, and resistin at all tested PNDs compared to the control group. Lithium Chloride 27-31 interleukin 1 beta Rattus norvegicus 156-174 31919846-7 2020 Simultaneously, repeated administration of J113863 reduced the protein levels of IBA-1 in the spinal cord and MPO and CD4 in the DRG and, as a consequence, the level of pronociceptive factors, such as IL-1beta, IL-6, and IL-18. UCB 35625 43-50 interleukin 1 beta Rattus norvegicus 201-209 31932642-10 2020 Meanwhile, CsA treatment significantly reduced serum IL-1beta, TNF-alpha, and IL-17 levels (P < 0.01), decreased the seizure scores and prolonged the latency to seizure (P < 0.01). Cyclosporine 11-14 interleukin 1 beta Rattus norvegicus 53-61 31823179-0 2020 p-Coumaric Acid Attenuates IL-1beta-Induced Inflammatory Responses and Cellular Senescence in Rat Chondrocytes. p-coumaric acids 0-15 interleukin 1 beta Rattus norvegicus 27-35 31823179-4 2020 In the present study, we aimed to investigate the effects of PCA on interleukin-1beta(IL-1beta)-induced inflammatory responses and cellular senescence in rat chondrocytes. p-coumaric acids 61-64 interleukin 1 beta Rattus norvegicus 68-85 31823179-4 2020 In the present study, we aimed to investigate the effects of PCA on interleukin-1beta(IL-1beta)-induced inflammatory responses and cellular senescence in rat chondrocytes. p-coumaric acids 61-64 interleukin 1 beta Rattus norvegicus 86-94 31823179-5 2020 Our results revealed that PCA remarkably downregulated IL-1beta-induced inflammatory factors such as COX2 and iNOS and cartilage-degrading enzymes like matrix metalloproteinases (MMP1, MMP3, and MMP13) and aggrecanases (ADAMTS4 and ADAMTS5) in chondrocytes. p-coumaric acids 26-29 interleukin 1 beta Rattus norvegicus 55-63 31823179-6 2020 The IL-1beta-induced degradation of cartilage matrix (collagen II and aggrecan) could also be suppressed by PCA. p-coumaric acids 108-111 interleukin 1 beta Rattus norvegicus 4-12 31823179-7 2020 Besides, PCA treatment effectively inhibited the IL-1beta-induced p16INK4a protein expression and SAbeta-gal activities in vitro. p-coumaric acids 9-12 interleukin 1 beta Rattus norvegicus 49-57 31823179-8 2020 Mechanism analysis showed that PCA suppressed IL-1beta-induced activation of mitogen-activated protein kinase (MAPK) and nuclear factor-kappaB (NF-kappaB) pathways. p-coumaric acids 31-34 interleukin 1 beta Rattus norvegicus 46-54 31823179-10 2020 Altogether, our findings implicate that p-coumaric acid attenuates IL-1beta-induced inflammatory responses and cellular senescence via inhibition of the MAPK and NF-kappaB signaling pathway in chondrocytes, and p-coumaric acid may be a promising candidate for the treatment of osteoarthritis. p-coumaric acids 40-55 interleukin 1 beta Rattus norvegicus 67-75 31955887-7 2020 PEG-UK was administrated 2 h and a half after ischemic stroke Delayed administration of PEG-UK significantly ameliorated the severity of neurological deficits of permanent middle cerebral occlusion (pMCAO) rats and reduced the infiltration of inflammatory cells and the concentration of interleukin 1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the brain tissues. peg-uk 88-94 interleukin 1 beta Rattus norvegicus 287-304 31852608-13 2020 The levels of mRNAs encoding TNF-alpha, IL-1beta, RAGE, and AGEs on the ligature sides were significantly upregulated (all P<0.05) in the STZ compared to the control group. Streptozocin 141-144 interleukin 1 beta Rattus norvegicus 40-48 31834465-10 2020 Immunohistochemical and immunoblotting findings showed that GLB improved the hepatic expressions of inflammatory markers (NLRP3, ASC, caspase-1, IL-1beta, NF-kappaB), anti-oxidant markers (SOD, catalase) and insulin signalling markers (p-AKT, p-GSK-3beta, p-IRS). Glyburide 60-63 interleukin 1 beta Rattus norvegicus 145-153 31916151-6 2020 BPA-treated rats showed significant reduction in BW gain and deteriorations in lipid profile, TAC, OGTT, and thyroid hormones as well as significant increases in HOMA-IR, IL-1beta, leptin, and resistin. bisphenol A 0-3 interleukin 1 beta Rattus norvegicus 171-179 32258120-7 2020 Furthermore, DOX caused an inflammatory reaction by elevating the levels of proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and endothelin- (ET-) 1, as well as nuclear factor kappa-B (NF-kappaB) expression. Doxorubicin 13-16 interleukin 1 beta Rattus norvegicus 144-161 30793820-6 2020 The aim of this study was to assess whether CBD prevents reinstatement of METH through change of gene expression of cytokines such as interleukin-1beta, interleukin-6, interleukin-10, and tumor necrosis factor alpha (TNF-alpha) in extinguished rats. Cannabidiol 44-47 interleukin 1 beta Rattus norvegicus 134-151 32226385-2 2020 Inflammation, in particular interleukin-1beta (IL-1beta), is increased in early stages of the disorder, and contributes to inner and outer retinal vasoobliteration in the oxygen-induced retinopathy (OIR) model of ROP. Oxygen 171-177 interleukin 1 beta Rattus norvegicus 28-45 31677374-6 2020 Baicalein reduced the frequency of nasal/ear rubs and sneezes in rats, and inhibited generation of several inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) in both blood and nasal lavage of rats. baicalein 0-9 interleukin 1 beta Rattus norvegicus 142-150 30994109-11 2020 At postoperative 12 h, resveratrol significantly reduced serum levels TNF-alpha, IL-1beta and IL-6 in CLP rats (P<0.05), whereas elevated that of IL-10 (P<0.05). Resveratrol 23-34 interleukin 1 beta Rattus norvegicus 81-89 31674072-7 2020 Meanwhile, the expressions of interleukin-1beta, tumor necrosis factor-alpha, chemokine c-X3-c-motif ligand 1, and C-C motif chemokine ligand 2 were greatly increased in CCI rats, but these effects were reversed by Dex. Dexmedetomidine 215-218 interleukin 1 beta Rattus norvegicus 30-76 31773988-6 2020 In their comparison to the control groups, the BNP levels increase and the IL-6 and IL-1beta levels decreased in the CGTX-III groups. angoletin 117-125 interleukin 1 beta Rattus norvegicus 84-92 32153398-6 2020 Moreover, the levels of inflammatory cytokines including interleukin-1beta (IL-1beta) and IL-18, which mediated by NLRP3 inflammasome and increased in MCAO rats, could be reduced by QNDP, suggesting that QNDP could protect the neurons against inflammation through a mechanism mediated by NLRP3 inflammasome. qndp 182-186 interleukin 1 beta Rattus norvegicus 57-74 31747348-12 2020 UA significantly decreased adiposity, IR, hyperinsulinemia, triacylglycerides, and cholesterol levels, and also VAT mRNA expression of MCP-1 (monocyte chemoattractant protein-1), IL (interleukin)-1beta and IL-6, concomitantly increasing adiponectin levels. ursolic acid 0-2 interleukin 1 beta Rattus norvegicus 179-201 31620822-8 2020 Furthermore, CH reversed the changes in levels of inflammatory, apoptotic, and autophagic parameters such as NF-kappaB, TNF-alpha, IL-1beta, IL-6, iNOS, COX-2, Bax, Bcl-2, and LC3B in liver and kidney tissues. chrysin 13-15 interleukin 1 beta Rattus norvegicus 131-139 31900895-9 2020 Our results also showed the protective effects of melatonin against METH neurotoxic profiles, characterized by reactive gliosis: microglia (integrin-alphaM) and astrocyte (GFAP); an excessive upregulation of primary pro-inflammatory cytokines: interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha); activation of neuroinflammatory signaling: nuclear factor-kappa B (NF-kappaB); and suppression of anti-oxidative signaling: nuclear factor erythroid 2-related factor (Nrf2), that may exacerbate BBB structural impairment. Melatonin 50-59 interleukin 1 beta Rattus norvegicus 244-261 31900895-9 2020 Our results also showed the protective effects of melatonin against METH neurotoxic profiles, characterized by reactive gliosis: microglia (integrin-alphaM) and astrocyte (GFAP); an excessive upregulation of primary pro-inflammatory cytokines: interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha); activation of neuroinflammatory signaling: nuclear factor-kappa B (NF-kappaB); and suppression of anti-oxidative signaling: nuclear factor erythroid 2-related factor (Nrf2), that may exacerbate BBB structural impairment. Melatonin 50-59 interleukin 1 beta Rattus norvegicus 263-271 31898581-12 2020 Translocation of nuclearfactor-kappa B (NF-kappaB) and upregulation of p-p65, TNF-alpha, IL-1beta were inhibited by l-CDL. corydalmine 116-121 interleukin 1 beta Rattus norvegicus 89-97 31779506-4 2020 DAS treatment before CP significantly decreased serum urea, creatinine, sodium, potassium, calcium, blood urea nitrogen (BUN), C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1beta (IL-1ss) and tumor necrosis factor-alpha (TNF-alpha) compared with CP-treated rats. allyl sulfide 0-3 interleukin 1 beta Rattus norvegicus 175-192 32153398-6 2020 Moreover, the levels of inflammatory cytokines including interleukin-1beta (IL-1beta) and IL-18, which mediated by NLRP3 inflammasome and increased in MCAO rats, could be reduced by QNDP, suggesting that QNDP could protect the neurons against inflammation through a mechanism mediated by NLRP3 inflammasome. qndp 204-208 interleukin 1 beta Rattus norvegicus 57-74 31899146-6 2020 Syringin inhibited DSS or LPS-induced overproduction of proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) and proinflammatory substances (iNOS, COX-2). syringin 0-8 interleukin 1 beta Rattus norvegicus 83-91 31554962-4 2020 Primary rat astrocytes were pretreated with ICS II (5, 10, and 20 muM) or dexamethasone (DXMS, 1 muM) for 1 h, thereafter, treated with LPS for another 24 h. We found that ICS II pretreatment dose dependently mitigated the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) in the astrocytes. baohuoside I 44-50 interleukin 1 beta Rattus norvegicus 274-292 32104544-6 2020 Rats with STZ-induced diabetes, with or without AFB1 intoxication, had significantly elevated activities of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, and levels of serum urea, creatinine, cholesterol, 8-oxo-2"-deoxyguanosine, interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha. Streptozocin 10-13 interleukin 1 beta Rattus norvegicus 270-287 32104544-6 2020 Rats with STZ-induced diabetes, with or without AFB1 intoxication, had significantly elevated activities of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, and levels of serum urea, creatinine, cholesterol, 8-oxo-2"-deoxyguanosine, interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha. Aflatoxin B1 48-52 interleukin 1 beta Rattus norvegicus 270-287 31554962-4 2020 Primary rat astrocytes were pretreated with ICS II (5, 10, and 20 muM) or dexamethasone (DXMS, 1 muM) for 1 h, thereafter, treated with LPS for another 24 h. We found that ICS II pretreatment dose dependently mitigated the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) in the astrocytes. baohuoside I 44-50 interleukin 1 beta Rattus norvegicus 294-302 31554962-4 2020 Primary rat astrocytes were pretreated with ICS II (5, 10, and 20 muM) or dexamethasone (DXMS, 1 muM) for 1 h, thereafter, treated with LPS for another 24 h. We found that ICS II pretreatment dose dependently mitigated the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) in the astrocytes. baohuoside I 172-178 interleukin 1 beta Rattus norvegicus 274-292 31554962-4 2020 Primary rat astrocytes were pretreated with ICS II (5, 10, and 20 muM) or dexamethasone (DXMS, 1 muM) for 1 h, thereafter, treated with LPS for another 24 h. We found that ICS II pretreatment dose dependently mitigated the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) in the astrocytes. baohuoside I 172-178 interleukin 1 beta Rattus norvegicus 294-302 31776306-9 2020 Moreover, the curcumin operation inhibited the activated of NF-kappaB and level of inflammatory factors like tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6). Curcumin 14-22 interleukin 1 beta Rattus norvegicus 150-167 31054068-6 2020 Glu-Sr also antagonized the catabolic effects of IL-1beta on chondrocytes. Glutamic Acid 0-3 interleukin 1 beta Rattus norvegicus 49-57 31081996-0 2020 Hyaluronic acid hydrogel loaded by adipose stem cells enhances wound healing by modulating IL-1beta, TGF-beta1, and bFGF in burn wound model in rat. Hyaluronic Acid 0-15 interleukin 1 beta Rattus norvegicus 91-99 31633274-6 2020 Furthermore, resveratrol reduced the contents of inflammatory cytokines; tumor necrosis factor alpha (TNF-alpha), nuclear factor-kappa (NF-kappaB), and interleukin 1beta (IL-1beta) in intestine. resveratrol 13-24 interleukin 1 beta Rattus norvegicus 152-169 31633274-6 2020 Furthermore, resveratrol reduced the contents of inflammatory cytokines; tumor necrosis factor alpha (TNF-alpha), nuclear factor-kappa (NF-kappaB), and interleukin 1beta (IL-1beta) in intestine. resveratrol 13-24 interleukin 1 beta Rattus norvegicus 171-179 31639282-5 2020 Additionally, omega-3FA administration markedly suppressed the increase in hepatic and renal myeloperoxidase activity, nitric oxide, tumor necrosis factor alpha, and interleukin-1 beta levels in the co-exposure group. Fatty Acids, Omega-3 14-23 interleukin 1 beta Rattus norvegicus 166-184 31541222-10 2020 Furthermore, clodronate treatment attenuated the increase in blood pressure and renal sympathetic nerve activity in response to an acute intravenous injection of interleukin-1beta in WKY. Clodronic Acid 13-23 interleukin 1 beta Rattus norvegicus 162-179 31642732-1 2020 This study was conducted to evaluate the protective effects of chamazulene against IL-1beta-induced rat primary chondrocytes and complete Freund"s adjuvant (CFA)-induced osteoarthritic inflammation in rats. chamazulene 63-74 interleukin 1 beta Rattus norvegicus 83-91 31642732-3 2020 Chamazulene significantly reverted (p < 0.05) the levels of lipid peroxidation and enhanced the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) enzymes against IL-1beta and CFA-induced oxidative stress. chamazulene 0-11 interleukin 1 beta Rattus norvegicus 205-213 31642732-4 2020 The levels of TNF-alpha and IL-6 were reduced (p < 0.05) in chamazulene treatment against IL-1beta and CFA-induced inflammation. chamazulene 63-74 interleukin 1 beta Rattus norvegicus 93-101 31642732-5 2020 Western blot analysis results on the expressions of MMP-3, MMP-9, p65 NF-kbeta, iNOS, and COX-2 showed chamazulene was able to protect the chondrocytes against IL-1beta-induced osteoarthritic inflammation. chamazulene 103-114 interleukin 1 beta Rattus norvegicus 160-168 31778663-11 2020 Both PFT-alpha and PFT-mu lowered TBI-induced pro-inflammatory cytokines (IL-1beta and IL-6) mRNA levels as well as TBI-induced autophagic marker localization (LC3 and p62). pifithrin 5-8 interleukin 1 beta Rattus norvegicus 74-82 31778663-11 2020 Both PFT-alpha and PFT-mu lowered TBI-induced pro-inflammatory cytokines (IL-1beta and IL-6) mRNA levels as well as TBI-induced autophagic marker localization (LC3 and p62). pifithrin 19-22 interleukin 1 beta Rattus norvegicus 74-82 31321575-7 2020 The colon shortening, myeloperoxidase activity, and colonic expression of IL-1beta, IL-6 and iNOS were downregulated in a dose-dependent manner in DNBS-induced colitis rats treated with PD123319 and the anti-oxidant defense machinery was also improved. 2,4-dinitrobenzenesulfonic acid 147-151 interleukin 1 beta Rattus norvegicus 74-82 31321575-7 2020 The colon shortening, myeloperoxidase activity, and colonic expression of IL-1beta, IL-6 and iNOS were downregulated in a dose-dependent manner in DNBS-induced colitis rats treated with PD123319 and the anti-oxidant defense machinery was also improved. PD 123319 186-194 interleukin 1 beta Rattus norvegicus 74-82 31352642-11 2020 Increases of IL-1beta, TNF-alpha, nitric oxide, and malondialdehyde and the decrease of glutathione induced by LPS were significantly attenuated by pretreatment with different doses of BA in plasma and aortas (p < 0.05 versus LPS), all of which were blocked by Bru (p < 0.01). betulinic acid 185-187 interleukin 1 beta Rattus norvegicus 13-21 30621446-0 2020 Enhancement of autophagy flux by isopsoralen ameliorates interleukin-1beta-stimulated apoptosis in rat chondrocytes. angelicin 33-44 interleukin 1 beta Rattus norvegicus 57-74 30621446-2 2020 We found that isopsoralen pretreatment significantly reversed the increase in DNA fragmentation and apoptosis rate, and significantly decreased the caspase-3 activity and PARP cleavage in IL-1beta-treated chondrocytes. angelicin 14-25 interleukin 1 beta Rattus norvegicus 188-196 30621446-5 2020 Importantly, the protective effects of isopsoralen against IL-1beta were blocked by pretreatment with autophagy inhibitor 3-MA and bafilomycin A1. angelicin 39-50 interleukin 1 beta Rattus norvegicus 59-67 30621446-5 2020 Importantly, the protective effects of isopsoralen against IL-1beta were blocked by pretreatment with autophagy inhibitor 3-MA and bafilomycin A1. 3-methyladenine 122-126 interleukin 1 beta Rattus norvegicus 59-67 30621446-5 2020 Importantly, the protective effects of isopsoralen against IL-1beta were blocked by pretreatment with autophagy inhibitor 3-MA and bafilomycin A1. bafilomycin A1 131-145 interleukin 1 beta Rattus norvegicus 59-67 31860774-8 2020 The gene expression pattern of neuroinflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) were decreased in the neferine-treated rats. neferine 185-193 interleukin 1 beta Rattus norvegicus 134-151 31942583-9 2020 Additionally, delivering genistein via an oil vehicle was more efficient at reducing MDA formation, MPO activity, and IL-1beta concentration than genistein in aqueous solution. Genistein 25-34 interleukin 1 beta Rattus norvegicus 118-126 32016839-9 2020 In addition, the elevated level of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) was decreased by modafinil. modafinil 125-134 interleukin 1 beta Rattus norvegicus 35-52 31612296-10 2020 The OA and OA + AuNP groups showed increased interleukin (IL)-1 beta in the hippocampus and cortex, and the AuNP group showed increased IL-1 beta in the hippocampus. Gold 16-20 interleukin 1 beta Rattus norvegicus 45-68 31612296-10 2020 The OA and OA + AuNP groups showed increased interleukin (IL)-1 beta in the hippocampus and cortex, and the AuNP group showed increased IL-1 beta in the hippocampus. Gold 108-112 interleukin 1 beta Rattus norvegicus 136-145 32086107-7 2020 Expression of renal inflammatory cytokines including tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) and apoptosis were also elevated in the DOX group. Doxorubicin 167-170 interleukin 1 beta Rattus norvegicus 97-115 31902439-8 2020 Also, diosmin treatment significantly (P < 0.05) lowered the levels of interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), down-regulated cardiac Bcl-2-associated X protein and caspase 3 and 9 and up-regulated B-cell lymphoma 2 mRNA expression levels. Diosmin 6-13 interleukin 1 beta Rattus norvegicus 74-91 31902439-8 2020 Also, diosmin treatment significantly (P < 0.05) lowered the levels of interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), down-regulated cardiac Bcl-2-associated X protein and caspase 3 and 9 and up-regulated B-cell lymphoma 2 mRNA expression levels. Diosmin 6-13 interleukin 1 beta Rattus norvegicus 93-101 31895751-6 2020 Oxycodone also decreased both the mRNA and protein expression levels of proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta. Oxycodone 0-9 interleukin 1 beta Rattus norvegicus 165-182 31715292-7 2020 Hesperidin treatment in rats with SCI reduced the neuropathological changes (e.g., hemorrhage, inflammatory cell infiltration, and tissue loss) and pro-inflammatory cytokines including tumor necrotic factor-alpha and interleukin-1beta. Hesperidin 0-10 interleukin 1 beta Rattus norvegicus 217-234 31688420-5 2020 The levels of interleukin-6, interleukin-1beta, tumor necrosis factor-alpha, and corticotropin-releasing hormone concentration in the serum were inhibited effectively by CP154526 or fluoxetine administration. CP 154526 170-178 interleukin 1 beta Rattus norvegicus 29-75 31688420-5 2020 The levels of interleukin-6, interleukin-1beta, tumor necrosis factor-alpha, and corticotropin-releasing hormone concentration in the serum were inhibited effectively by CP154526 or fluoxetine administration. Fluoxetine 182-192 interleukin 1 beta Rattus norvegicus 29-75 31711915-7 2020 RESULTS: Previous to IR, the EPA+DHA administration improved the rate and prolonged the survival time by decreasing the AST and ALT levels and improving liver degenerative changes generated by the IR, which decreased TNF-alpha and IL-1beta. 2,3-epoxypropyl acrylate 29-32 interleukin 1 beta Rattus norvegicus 231-239 31711915-7 2020 RESULTS: Previous to IR, the EPA+DHA administration improved the rate and prolonged the survival time by decreasing the AST and ALT levels and improving liver degenerative changes generated by the IR, which decreased TNF-alpha and IL-1beta. docosahexaenoylascorbic acid 33-36 interleukin 1 beta Rattus norvegicus 231-239 31731189-5 2020 We found that FSK and STZ significantly increased the hyperphosphorylated tau level, pyroptosis-related protein in PC12 cell and rats" brain, and inhibited the activity of caspase-1 by caspase-1 inhibitor, caspase-1 siRNA, or incubated with Interleukin(IL)-1beta/IL-18 neutralizing antibody could notably alleviate the FSK and STZ induced PC12 cells damage and improve the cognitive disorder in ICV-FSK and ICV-STZ rats. Colforsin 14-17 interleukin 1 beta Rattus norvegicus 241-262 31715312-10 2020 Furthermore, a significant increase in the expression level of NLRC4 inflammasome, ASC and IL-1beta was identified in STZ-treated animals. Streptozocin 118-121 interleukin 1 beta Rattus norvegicus 91-99 31715312-12 2020 Moreover, the number of caspase-1, IL-1beta and p-Tau protein positive cells were remarkably increased in STZ-treated animals. Streptozocin 106-109 interleukin 1 beta Rattus norvegicus 35-43 31654756-7 2020 We also measured concentrations of IL-1beta, Il-6 and uric acid in serum.Allopurinol dose-dependently ameliorated biochemical injuries. Allopurinol 73-84 interleukin 1 beta Rattus norvegicus 35-43 31734518-7 2020 Additionally, nickel mediated decrease in antioxidant enzyme activities as well as the increase in tumour necrosis factor alpha, interleukin-1 beta and caspase-3 activity were markedly abrogated in the cerebrum, cerebellum and liver of rats co-exposed to nickel and zinc. Nickel 14-20 interleukin 1 beta Rattus norvegicus 129-147 31921607-8 2020 Results: Data showed that 100 mg/kg of pCA significantly suppressed LDH activity (p<0.05), IL-18 (p<0.05) and IL-1beta (p<0.01) level in heart tissue. p-coumaric acids 39-42 interleukin 1 beta Rattus norvegicus 116-124 31840221-8 2020 In addition, excessive release of tumor necrosis factor-alpha and interleukin-1beta was recorded in response to HgCl2 intoxication. Mercuric Chloride 112-117 interleukin 1 beta Rattus norvegicus 66-83 31347173-12 2020 Interestingly, we observed that miR-495-3p mimics repressed tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-18 protein expression while their levels were enhanced by the inhibition of miR-495-3p in H9c2 cells. mir-495-3p 32-42 interleukin 1 beta Rattus norvegicus 101-118 31600566-8 2020 In particular, oxidative DNA damages, MDA, TGF-beta, IL-1beta, and IL-6 levels were significantly reduced in STZ-treated rats following treatment with CH extract, whereas IL-10 showed opposite trend. Streptozocin 109-112 interleukin 1 beta Rattus norvegicus 53-61 31837574-0 2020 Protectin DX attenuates IL-1beta-induced inflammation via the AMPK/NF-kappaB pathway in chondrocytes and ameliorates osteoarthritis progression in a rat model. 10,17-dihydroxydocosa-4,7,11,13,15,19-hexaenoic acid 0-12 interleukin 1 beta Rattus norvegicus 24-32 31837574-4 2020 Primary rat chondrocytes were preincubated with PDX 1 h prior to IL-1beta treatment for 24 h. We found that PDX was nontoxic, and pretreatment with PDX increased cell viability in IL-1beta-induced chondrocytes. 10,17-dihydroxydocosa-4,7,11,13,15,19-hexaenoic acid 48-51 interleukin 1 beta Rattus norvegicus 180-188 31837574-4 2020 Primary rat chondrocytes were preincubated with PDX 1 h prior to IL-1beta treatment for 24 h. We found that PDX was nontoxic, and pretreatment with PDX increased cell viability in IL-1beta-induced chondrocytes. 10,17-dihydroxydocosa-4,7,11,13,15,19-hexaenoic acid 108-111 interleukin 1 beta Rattus norvegicus 65-73 31837574-6 2020 Additionally, the expression of MMP-3, MMP-13, ADAMTS4, iNOS, COX-2, NO, and PGE2 decreased after IL-1beta stimulation when cells were preincubated with PDX. Dinoprostone 77-81 interleukin 1 beta Rattus norvegicus 98-106 31837574-6 2020 Additionally, the expression of MMP-3, MMP-13, ADAMTS4, iNOS, COX-2, NO, and PGE2 decreased after IL-1beta stimulation when cells were preincubated with PDX. 10,17-dihydroxydocosa-4,7,11,13,15,19-hexaenoic acid 153-156 interleukin 1 beta Rattus norvegicus 98-106 31837574-7 2020 Moreover, PDX inhibited the increase in phosphorylated NF-kappaB p65 and IkappaBalpha upon IL-1beta stimulation, and the negative effects of IL-1beta on chondrocytes were partially blocked by treatment with pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor. 10,17-dihydroxydocosa-4,7,11,13,15,19-hexaenoic acid 10-13 interleukin 1 beta Rattus norvegicus 91-99 31837574-7 2020 Moreover, PDX inhibited the increase in phosphorylated NF-kappaB p65 and IkappaBalpha upon IL-1beta stimulation, and the negative effects of IL-1beta on chondrocytes were partially blocked by treatment with pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor. pyrrolidine dithiocarbamic acid 207-234 interleukin 1 beta Rattus norvegicus 91-99 31837574-7 2020 Moreover, PDX inhibited the increase in phosphorylated NF-kappaB p65 and IkappaBalpha upon IL-1beta stimulation, and the negative effects of IL-1beta on chondrocytes were partially blocked by treatment with pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor. pyrrolidine dithiocarbamic acid 207-234 interleukin 1 beta Rattus norvegicus 141-149 31837574-7 2020 Moreover, PDX inhibited the increase in phosphorylated NF-kappaB p65 and IkappaBalpha upon IL-1beta stimulation, and the negative effects of IL-1beta on chondrocytes were partially blocked by treatment with pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor. pyrrolidine dithiocarbamic acid 236-240 interleukin 1 beta Rattus norvegicus 141-149 31837574-8 2020 In addition, we found that PDX increased AMPK phosphorylation in IL-1beta-mediated chondrocytes. 10,17-dihydroxydocosa-4,7,11,13,15,19-hexaenoic acid 27-30 interleukin 1 beta Rattus norvegicus 65-73 31740420-10 2020 It should be noted that treatment with Ritalin could significantly increase TNF-alpha and IL-1beta levels in isolated cerebellar cells (p < 0.05). Methylphenidate 39-46 interleukin 1 beta Rattus norvegicus 90-98 31908572-6 2020 CAR administration significantly attenuated expression of several inflammatory factors in the brain, including interleukin-1beta, tumor necrosis factor-alpha, and cyclooxygenase-2. carvacrol 0-3 interleukin 1 beta Rattus norvegicus 111-157 30660765-5 2020 Bexarotene 50mg/kg/day inhibited CCI-induced MAPKs (p38MAPK, ERK1/2, and JNK) activation and upregulation of proinflammatory factors(IL-1beta, TNF-alpha and IL-6). Bexarotene 0-10 interleukin 1 beta Rattus norvegicus 133-141 30660765-5 2020 Bexarotene 50mg/kg/day inhibited CCI-induced MAPKs (p38MAPK, ERK1/2, and JNK) activation and upregulation of proinflammatory factors(IL-1beta, TNF-alpha and IL-6). CCI 33-36 interleukin 1 beta Rattus norvegicus 133-141 31694784-10 2020 Moreover, we demonstrated that edaravone shared a similar effect with MCC950 on alleviating neurodegeneration and decreasing the expression of IL-1beta, Caspase 1 and NF-kappaB in protein or mRNA. edaravone 31-40 interleukin 1 beta Rattus norvegicus 143-151 32879255-10 2020 Furthermore, it was shown that treatment of lead acetate increased the release of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the accumulation of malondialdehyde (MDA) and myeloperoxidase (MPO) in astrocytes, which could be alleviated by further 3-MA induction. lead acetate 44-56 interleukin 1 beta Rattus norvegicus 126-143 31876072-4 2020 In IL-1beta-stimulated rat chondrocytes, amurensin H suppresses the production of inflammatory mediators including nitric oxide, IL-6, IL-17, PGE2 and TNF-alpha using Greiss and ELISA assay. amurensin H 41-52 interleukin 1 beta Rattus norvegicus 3-11 31877779-7 2019 Additionally, PbAc increased the release and expression of the pro-inflammatory cytokines (tumor necrosis factor alpha and interleukin-1 beta), inducible nitric oxide synthase, and nuclear factor kappa B. Lead 14-18 interleukin 1 beta Rattus norvegicus 123-141 31624995-11 2020 VPA administration significantly increased the levels of alpha-GST, MDA, NF-kappaB and of IL-1beta, TNF-alpha gene expression in the liver compared to Group C. Moreover, vacuolization, hydropic degeneration, inflammatory cell infiltration, and sinusoidal congestion were commonly detected in the VPA-treated group along with the highest apoptotic index (TUNEL staining) values. Valproic Acid 0-3 interleukin 1 beta Rattus norvegicus 90-98 31949465-2 2019 Succinate is an inflammatory metabolic signal that exacerbates RA synovitis by activating succinate receptor 1 (SUCNR1) to amplify the release of IL-1beta. Succinates 0-9 interleukin 1 beta Rattus norvegicus 146-154 31949465-2 2019 Succinate is an inflammatory metabolic signal that exacerbates RA synovitis by activating succinate receptor 1 (SUCNR1) to amplify the release of IL-1beta. Succinates 90-99 interleukin 1 beta Rattus norvegicus 146-154 31535655-11 2020 Ilexonin A enhanced nestin expression and reduced the expression of tumor necrosis factor-alpha and interleukin 1beta in the hippocampus post-ischemia/reperfusion. ilexonin A 0-10 interleukin 1 beta Rattus norvegicus 100-117 31678059-8 2020 Moreover, selenium diminished inflammatory parameters (myeloperoxidase activity, nitric oxide, tumour necrosis factor alpha and interleukin-1 beta levels), caspase-3 activity and ameliorated histological lesions in the cerebellum, cerebrum and liver of the rats. Selenium 10-18 interleukin 1 beta Rattus norvegicus 128-146 31704101-7 2020 Furthermore, combined administration of Can and Nan increased oxidative stress (significantly increased malondialdehyde and nitric oxide levels and reduced glutathione content), elevated brain pro-inflammatory cytokines (tumour necrosis factor alpha and interleukin 1 beta), and upregulated caspase-3, caspase-8, and caspase-9 mRNA expression and cytochrome c levels. nan 48-51 interleukin 1 beta Rattus norvegicus 254-272 31590920-4 2019 Co-treatment of cells with a cocktail of pro-inflammatory cytokines (IL-1beta, IFNgamma and TNFalpha) caused a marked increase in caspase activation and a reduction in cell viability, effects attenuated by inclusion of each EET; this was also associated with a reduction in cytokine-induced NFkappaB activation and nitrite accumulation. Nitrites 315-322 interleukin 1 beta Rattus norvegicus 69-77 31933629-8 2019 Furthermore, EP significantly suppressed the mRNA expression levels of HMGB1, IL-1beta, TNF-alpha, and HSP27. ethyl pyruvate 13-15 interleukin 1 beta Rattus norvegicus 78-86 31921865-9 2019 HI-induced increase in systemic IL-6 levels and tissue expression of IL-6, IL-10, IL-1beta, and IL-18 genes in the heart were attenuated with NiDaR treatment. resveratrol 142-147 interleukin 1 beta Rattus norvegicus 82-90 31618621-13 2019 The flavonoid also preserved NF-kappaB, IL-1beta, IL-10, TGF-beta, CTGF, Col-I, MMP-13 and Smad7 protein levels. Flavonoids 4-13 interleukin 1 beta Rattus norvegicus 40-48 31518574-7 2019 CUMS-induced depressive-like behaviors were coupled with the overactivation of NLRP1 and NLRP3 inflammasome sensors and increased levels of IL-1beta. cums 0-4 interleukin 1 beta Rattus norvegicus 140-148 31589333-11 2019 In the frontal cortex adolescent ethanol exposure induced an increase of IL-1beta at day 35, and 28 days of withdrawal, and IL-10 was increased after 28 days of withdrawal. Ethanol 33-40 interleukin 1 beta Rattus norvegicus 73-81 31824881-6 2019 Results: The protective and therapeutic actions of ruscogenin were accomplished by improvements in histopathology, by decreasing blood cytokine levels of CRP, hs-CRP levels, TNF-alpha, IL-6, IL-1beta, ICAM-1, by reducing the pancreatic enzymes amylase and lipase in blood, and by suppressing the expression of nuclear factor kappa B, ICAM-1, and NOS-1, but not MDA in pancreatic tissues. ruscogenin 51-61 interleukin 1 beta Rattus norvegicus 191-199 31586635-7 2019 Administration of isorhamnetin decreased CD68-positive cells and mRNA levels of IL-6, TNF-alpha, and IL-1beta in the esophagus of RE rats. 3-methylquercetin 18-30 interleukin 1 beta Rattus norvegicus 101-109 31398612-8 2019 Further, zinc abrogated nickel-mediated elevation in inflammatory biomarkers including nitric oxide, tumor necrosis factor alpha, interleukin-1 beta as well as caspase-3 activity. Nickel 24-30 interleukin 1 beta Rattus norvegicus 130-148 31623841-9 2019 In DEX-treated rats after injury, tissue RNA expression indicated a significant downregulation of pro-inflammatory markers (e.g. interleukin [IL]-1beta, tumour necrosis factor-alpha, interleukin (IL)-6, and CD11b) and an upregulation of anti-inflammatory and pro-resolving M2 responses (e.g. IL-4, arginase-1, and CD206) (P<0.05). Dexmedetomidine 3-6 interleukin 1 beta Rattus norvegicus 142-181 31586631-6 2019 Anion secretion induced by histamine was downregulated in the presence of interleukin-1beta (IL-1beta) and the cytokine mix, whereas the response to the mast cell stimulator compound 48/80 was not changed significantly. Histamine 27-36 interleukin 1 beta Rattus norvegicus 74-91 31550528-6 2019 In vitro, quercetin remarkably suppressed the expression of matrix degrading proteases and inflammatory mediators, meantime promoted the production of cartilage anabolic factors in interleukin-1beta-induced (IL-1beta) rat chondrocytes. Quercetin 10-19 interleukin 1 beta Rattus norvegicus 181-198 31512108-0 2019 Isorhapontigenin Suppresses Interleukin-1beta-Induced Inflammation and Cartilage Matrix Damage in Rat Chondrocytes. isorhapontigenin 0-16 interleukin 1 beta Rattus norvegicus 28-45 31473901-8 2019 However, oral administration of trans-chalcone reduced TNF-alpha, IL-1beta, IL-6 (P < 0.001), and miR-146a (P < 0.05) expression levels and also improved HFD-induced histological abnormalities. Chalcone 32-46 interleukin 1 beta Rattus norvegicus 66-74 31512108-5 2019 Here, we investigated the effects of ISO on interleukin-1beta (IL-1beta)-treated rat chondrocytes and cartilage explants. isorhapontigenin 37-40 interleukin 1 beta Rattus norvegicus 44-61 31604145-11 2019 PAG was able to reduce levels of CBS, CSE, TNF-alpha, and IL-1beta in the TMJ and TG, after 13 days of CFA injection. pag 0-3 interleukin 1 beta Rattus norvegicus 58-66 31446615-11 2019 Similarly, JWH-133 application decreased the serum tumour necrosis factor alpha, blood urea nitrogen, creatinine, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, Cystatin C, interleukin-18, interleukin-1beta, interleukin-6, and interleukin-10 levels. 1,1-dimethylbutyl-1-deoxy-Delta(9)-THC 11-18 interleukin 1 beta Rattus norvegicus 212-229 31372695-9 2019 Pretreatment with cilostazol reduced ulcer number and severity, ameliorated redox status (reduced glutathione and malonaldehyde content), and decreased levels of IL-1beta, IL-6, and TNF- in gastric mucosa, in parallel with increases in mucosal defensive factors nitric oxide (NO), prostaglandin E2 (PGE2), and heat-shock protein 70 (HSP70) promoting mucus secretion, tissue perfusion, and regeneration. Cilostazol 18-28 interleukin 1 beta Rattus norvegicus 162-170 31704291-6 2019 Our results demonstrated that pinocembrin treatment significantly decreased sympathetic activity, augmented parasympathetic activity, improved heart rate variability (HRV), prolonged the atrial effective refractory period (ERP) and action potential duration (APD), shortened activation latency (AL), lowered the indicibility rate of AF, attenuated atrial fibrosis, and decreased concentrations of norepinephrine (NE), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in the serum and the left atrial (LA). pinocembrin 30-41 interleukin 1 beta Rattus norvegicus 459-481 31368063-8 2019 In addition, ELISAs of TNF-alpha (tumor necrosis factor-alpha), IL-1beta (interleukin-1 beta), IL-6 (interleukin-6), and BDNF supported an effect of sevoflurane on inflammatory cytokines and a neurotrophic factor. Sevoflurane 149-160 interleukin 1 beta Rattus norvegicus 74-92 31622116-6 2019 Results: In the gouty arthritis rat model, BHA at a higher dosage (50 mug) demonstrated a strong anti-inflammatory effect by reducing the degree of articular swelling and the serum levels of IL-1beta, IL-8, IFN-gamma, and MCP-1 by 5.56%, 6.55%, 15.58% and 33.18%. Butylated Hydroxyanisole 43-46 interleukin 1 beta Rattus norvegicus 191-199 31496325-9 2019 Meanwhile, Arg (600 microM) induced expression of proinflammatory cytokines (TNF-alpha, IL-6, IL-1beta, NF-kappaB, IL-17A/IL-17F and IFN-gamma) and activation of p-p38/p-ERK in vitro, which was reversed by OMT. Arginine 11-14 interleukin 1 beta Rattus norvegicus 94-102 31184936-7 2019 The mRNA and protein expression levels of serine-threonine kinase 2 (RIP2) and interleukin-1beta (IL-1beta) were significantly increased in the I/R and H2O2 groups when compared with the controls; however, these levels were significantly decreased after l-NAT intervention. Hydrogen Peroxide 152-156 interleukin 1 beta Rattus norvegicus 79-96 31670060-10 2019 Moreover, IL-1beta level was found significantly reduced in 7,8-DHF treated EtOH, HFD and EtOH+HFD groups. 6,7-dihydroxyflavone 60-67 interleukin 1 beta Rattus norvegicus 10-18 31496325-10 2019 In vivo, OMT (50 mg/kg) inhibited 250 mg/100 g of Arg-induced AP involving intestinal injury, including inhibiting Arg-induced inflammatory in pancreas and intestine, inhibiting Arg-induced increase of TNF-alpha, IL-6, IL-1beta, NF-kappaB and p-p38/p-ERK-MAPK signalling, and inhibiting Arg-induced increase of IL-17A/IL-17F, IFN-gamma, ROR-gammat and T-bet. oxymatrine 9-12 interleukin 1 beta Rattus norvegicus 219-227 31496325-10 2019 In vivo, OMT (50 mg/kg) inhibited 250 mg/100 g of Arg-induced AP involving intestinal injury, including inhibiting Arg-induced inflammatory in pancreas and intestine, inhibiting Arg-induced increase of TNF-alpha, IL-6, IL-1beta, NF-kappaB and p-p38/p-ERK-MAPK signalling, and inhibiting Arg-induced increase of IL-17A/IL-17F, IFN-gamma, ROR-gammat and T-bet. Arginine 50-53 interleukin 1 beta Rattus norvegicus 219-227 31670059-7 2019 Crocin attenuated the LPS-induced toxicity in H9c2 cells via reducing the levels of inflammatory factors (TNF-alpha, PGE2, IL-1beta, and IL-6, p < 0.001), gene expression (TNF-alpha, COX-2, IL-1beta, IL-6, and iNOS, p < 0.001), and NO (p < 0.001), whereas increased the level of thiol content (p < 0.001). crocin 0-6 interleukin 1 beta Rattus norvegicus 123-131 31670059-7 2019 Crocin attenuated the LPS-induced toxicity in H9c2 cells via reducing the levels of inflammatory factors (TNF-alpha, PGE2, IL-1beta, and IL-6, p < 0.001), gene expression (TNF-alpha, COX-2, IL-1beta, IL-6, and iNOS, p < 0.001), and NO (p < 0.001), whereas increased the level of thiol content (p < 0.001). crocin 0-6 interleukin 1 beta Rattus norvegicus 193-201 31670060-10 2019 Moreover, IL-1beta level was found significantly reduced in 7,8-DHF treated EtOH, HFD and EtOH+HFD groups. piperazine hydroxyethylamine 76-80 interleukin 1 beta Rattus norvegicus 10-18 31670060-10 2019 Moreover, IL-1beta level was found significantly reduced in 7,8-DHF treated EtOH, HFD and EtOH+HFD groups. piperazine hydroxyethylamine 90-94 interleukin 1 beta Rattus norvegicus 10-18 31408626-9 2019 An elevated level of reactive oxygen species was seen in aortic tissues together with increased Transforming growth factor beta1 and Interleukin-1beta expression. Reactive Oxygen Species 21-44 interleukin 1 beta Rattus norvegicus 133-150 31781346-11 2019 Histological analysis showed that aspirin treatment prevented the loss of COL2 and decreased MMP-3 and MMP-13, inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), IL-1beta, and TNF-alpha expression in the IVD tissues. Aspirin 34-41 interleukin 1 beta Rattus norvegicus 167-175 31772145-8 2019 Melatonin reduced inflammatory cell aggregation and the release of the inflammatory factors IL-1beta, IL-6, TNF-alpha as determined by immunohistochemistry. Melatonin 0-9 interleukin 1 beta Rattus norvegicus 92-100 31772145-9 2019 In conclusion, the present study demonstrated that melatonin could modulate ECM remodeling by IL-1beta in vitro and attenuate the IVDD and induction of inflammation in a rat tail puncture model in vivo. Melatonin 51-60 interleukin 1 beta Rattus norvegicus 94-102 31885644-7 2019 In addition, CPF induced inflammation in renal tissue as evidenced by increased release of tumor necrosis factor-alpha and interleukin-1beta and upregulation of inducible nitric oxide synthase. 1-(p-fluorphenacyl)-2-methyl-4-nitroimidazole 13-16 interleukin 1 beta Rattus norvegicus 123-140 31819412-2 2019 The aim of this study was to assess the anti-inflammatory comparative effect of curcumin solution with liposomal curcumin formula, regarding the improvement of serum levels of TNF-alpha (tumor necrosis factor-alpha), IL-6 (interleukin), IL-1alpha, IL-1beta, MCP-1 (monocyte chemoattractant protein-1) and RANTES in experimental diabetes, induced by streptozotocin (STZ), in rats. Curcumin 80-88 interleukin 1 beta Rattus norvegicus 248-256 31731792-9 2019 In vitro, polydatin inhibited hyperosmolar stress-induced inflammation through attenuation of the translocation of NF-kappaB to the nucleus and the mRNA expression of TNF-alpha, IL-6, IL-1beta, and MMP9. polydatin 10-19 interleukin 1 beta Rattus norvegicus 184-192 31781182-10 2019 The ethanol-induced increases of p-NF-kappaB-p65, TNF-alpha, and IL-1beta were dampened by overxpression of SENP6 and enhanced in SENP6-siRNA microglia. Ethanol 4-11 interleukin 1 beta Rattus norvegicus 65-73 31568203-10 2019 Moreover, remifentanil also increased the TNF-alpha, IL-1beta, and IL-6 levels and activates the astrocyte in spinal cord. remifentanil 10-22 interleukin 1 beta Rattus norvegicus 53-61 31759413-5 2019 Treatment with ASCs-containing honey (T-H/ASC) resulted in substantial reduction in the level of pro-inflammatory cytokines including interleukin-1beta (IL-1beta) and transforming growth factor-beta1 (TGF-beta1) in wound bed, at 7 day post-surgery. ascs 15-19 interleukin 1 beta Rattus norvegicus 134-151 31814912-8 2019 In the UTI group, IL-1beta was significantly lowly expressed than the ischemia hypoxia group. uti 7-10 interleukin 1 beta Rattus norvegicus 18-26 31717536-7 2019 DMH/DSS treatment induced preneoplastic aberrant crypt foci (ACF), elevated serum levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta, as well as decreased pro-apoptotic Bax expression. 1,2-Dimethylhydrazine 0-3 interleukin 1 beta Rattus norvegicus 150-158 31772727-10 2019 Chronic abuse of methamphetamine could increase malondialdehyde (MDA), tumor necrosis factor-Alpha (TNF-alpha) and interleukine-1beta (IL-1beta) while caused decreases in superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) activities and decreased CREB (both forms) and BDNF proteins, while duloxetine could prevent these malicious effects of methamphetamine. Methamphetamine 17-32 interleukin 1 beta Rattus norvegicus 135-143 31602208-10 2019 Additionally, puerarin decreased the levels inflammatory factors, including tumor necrosis factor alpha, interleukin (IL)-1beta and IL-6 in serum and myocardial tissue compared with the PBS group. puerarin 14-22 interleukin 1 beta Rattus norvegicus 105-127 31449943-4 2019 Pretreatment of animals with resveratrol restored intestinal dysfunction; reduced elevated MDA, MPO, IL-1beta, and TNF-alpha levels; and reversed the depleted intestine GSH levels after both 150 min and 24 h reperfusion periods. Resveratrol 29-40 interleukin 1 beta Rattus norvegicus 101-109 31449943-5 2019 CONCLUSIONS: The results indicated that resveratrol can reverse the effects of disrupted smooth muscle contractility, probably due to its antioxidant and anti-inflammatory effects on MPO, IL-1beta, and TNF-alpha activities. Resveratrol 40-51 interleukin 1 beta Rattus norvegicus 188-196 31690022-3 2019 The spikenard extract significantly inhibited IL-1beta-stimulated production of IL-6, IL-8, metalloproteinase (MMP)-1, MMP-13, cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS) and prostaglandin(PG)E2 in a dose-dependent manner but not MMP-3 production. Prostaglandins E 194-213 interleukin 1 beta Rattus norvegicus 46-54 31690022-4 2019 The extract also inhibited the IL-1beta-induced translocation of NF-kappaB/p65 into the nucleus and dose-dependent phosphorylation levels of extracellular signal-regulated kinase (ERK), Jun amino-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase. Amino Acids 190-195 interleukin 1 beta Rattus norvegicus 31-39 31473390-7 2019 Additionally, selenium or DPDS co-treatment prevented arsenic-mediated elevation in oxidative stress indices and significantly suppressed arsenic-mediated inflammation evidenced by diminished myeloperoxidase activity, nitric oxide, tumor necrosis factor alpha and interleukin-1 beta levels in hypothalamus, testes and epididymis of the rats. Selenium 14-22 interleukin 1 beta Rattus norvegicus 264-282 31473390-7 2019 Additionally, selenium or DPDS co-treatment prevented arsenic-mediated elevation in oxidative stress indices and significantly suppressed arsenic-mediated inflammation evidenced by diminished myeloperoxidase activity, nitric oxide, tumor necrosis factor alpha and interleukin-1 beta levels in hypothalamus, testes and epididymis of the rats. diphenyldiselenide 26-30 interleukin 1 beta Rattus norvegicus 264-282 31641386-10 2019 Results showed that lidocaine markedly reduced the hypoxia-induced expression levels of IL-1beta, TNF-alpha and IL-6 in a dose-dependent manner. Lidocaine 20-29 interleukin 1 beta Rattus norvegicus 88-96 31431087-7 2019 Administration of PCA markedly abated MTX-induced increases in interleukin-1beta, tumor necrosis factor alpha, and caspase 3 activity in the rats. Methotrexate 38-41 interleukin 1 beta Rattus norvegicus 63-80 31773715-19 2019 The mRNA expression levels of IL-1beta, TNF-alpha and NOX-1 were markedly higher in the model group and butylphthalide group than those of the sham group (p<0.05). 3-n-butylphthalide 104-118 interleukin 1 beta Rattus norvegicus 30-38 31773715-21 2019 In addition, the content of IL-1beta and TNF-alpha increased in the model group and butylphthalide group when compared with the sham group (p<0.05). 3-n-butylphthalide 84-98 interleukin 1 beta Rattus norvegicus 28-36 31773715-22 2019 The content of IL-1beta and TNF-alpha in the butylphthalide group was significantly lower than the model group (p<0.05). 3-n-butylphthalide 45-59 interleukin 1 beta Rattus norvegicus 15-23 31032956-11 2019 Furthermore, quantitative reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay demonstrated that extracellular UDP-glucose significantly enhanced interleukin-1beta (IL-1beta) and chemokine CCL2 (CCL2) release, which was abolished by PPTN and significantly decreased by inhibitors of MEK/ERK (U0126) and p38 (SB202190). Uridine Diphosphate Glucose 144-155 interleukin 1 beta Rattus norvegicus 179-196 31032956-11 2019 Furthermore, quantitative reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay demonstrated that extracellular UDP-glucose significantly enhanced interleukin-1beta (IL-1beta) and chemokine CCL2 (CCL2) release, which was abolished by PPTN and significantly decreased by inhibitors of MEK/ERK (U0126) and p38 (SB202190). Uridine Diphosphate Glucose 144-155 interleukin 1 beta Rattus norvegicus 198-206 31032956-11 2019 Furthermore, quantitative reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay demonstrated that extracellular UDP-glucose significantly enhanced interleukin-1beta (IL-1beta) and chemokine CCL2 (CCL2) release, which was abolished by PPTN and significantly decreased by inhibitors of MEK/ERK (U0126) and p38 (SB202190). PPTN 266-270 interleukin 1 beta Rattus norvegicus 179-196 31032956-11 2019 Furthermore, quantitative reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay demonstrated that extracellular UDP-glucose significantly enhanced interleukin-1beta (IL-1beta) and chemokine CCL2 (CCL2) release, which was abolished by PPTN and significantly decreased by inhibitors of MEK/ERK (U0126) and p38 (SB202190). U 0126 325-330 interleukin 1 beta Rattus norvegicus 179-196 30239309-5 2019 Resveratrol could restore RANKL/OPG ratio, slightly increase BMD, and moderately but significantly reduce IL-23, IL-17A, IL-1beta, and TNF-alpha cytokine expression levels. Resveratrol 0-11 interleukin 1 beta Rattus norvegicus 121-129 31106412-7 2019 RESULTS: The administration of omega-3 fatty acids and aspirin significantly inhibited tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in serum of rats. Fatty Acids, Omega-3 31-50 interleukin 1 beta Rattus norvegicus 131-148 31106412-7 2019 RESULTS: The administration of omega-3 fatty acids and aspirin significantly inhibited tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in serum of rats. Fatty Acids, Omega-3 31-50 interleukin 1 beta Rattus norvegicus 150-158 31106412-7 2019 RESULTS: The administration of omega-3 fatty acids and aspirin significantly inhibited tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in serum of rats. Aspirin 55-62 interleukin 1 beta Rattus norvegicus 131-148 31106412-7 2019 RESULTS: The administration of omega-3 fatty acids and aspirin significantly inhibited tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in serum of rats. Aspirin 55-62 interleukin 1 beta Rattus norvegicus 150-158 31197431-9 2019 Cisplatin pro-inflammatory response was reduced by PIC treatment as evidenced by the suppression of nuclear factor kappa-B activation and the subsequent decreased tissue levels of interleukin-1beta, tumor necrosis factor-alpha, cyclooxygenase-2, and inducible nitric oxide synthase. Cisplatin 0-9 interleukin 1 beta Rattus norvegicus 180-226 31465983-7 2019 RESULTS: GL significantly inhibited the IL-1beta stimulated cartilage degradation in vitro by mitigating the MMPs activity, collagen degradation and secretion of pro-inflammatory mediators. guggulu extract 9-11 interleukin 1 beta Rattus norvegicus 40-48 31495083-8 2019 Results: The levels of MDA, MPO, IL-1beta, and TNF-alpha in the lung tissue of the MTX were significantly higher than those of the MTXL and HG groups (p < 0.0001), and the amount of tGSH was lower. Methotrexate 83-86 interleukin 1 beta Rattus norvegicus 33-41 31407455-12 2019 Mechanistically, paeonol markedly reduced the expression of TNF-alpha, IL-1beta, and IL-6 in synovial tissues of MIA rats. paeonol 17-24 interleukin 1 beta Rattus norvegicus 71-79 31541796-12 2019 The biochemical data showed that TFCH significantly suppressed both systemic and intrahepatic inflammation by inhibiting IL-1beta, IL-6, IL-12, TNF-alpha, and IFN-gamma, and the qPCR analysis revealed a Th1/Th2 related anti-inflammatory mechanism of TFCH. tfch 33-37 interleukin 1 beta Rattus norvegicus 121-129 31781324-4 2019 Results: Compared with the PQ group, the MET treatment group showed significantly (1) reduced lung wet/dry ratio (W/D: 4.67 +- 0.31 vs. 5.45 +- 0.40, P < 0.001), (2) reduced pathological changes in lung tissue, (3) decreased MDA levels (nmol/mg prot: 2.70 +- 0.19 vs. 3.08 +- 0.15, P < 0.001) and increased SOD and GSH-Px activities (U/mg prot: 76.17 +- 5.22 vs. 45.23 +- 6.58, 30.40 +- 2.84 vs. 21.00 +- 3.20; all P < 0.001) in lung tissue homogenate, (4) reduced levels of IL-1beta, IL-6, and TNF-alpha in lung tissue homogenates (pg/mL: 47.87 +- 5.06 vs. 66.77 +- 6.55; 93.03 +- 7.41 vs. 107.39 +- 9.81; 75.73 +- 6.08 vs. 89.12 +- 8.94; all P < 0.001), (5) increased activity of RLE-6TN cells (%: 0.69 +- 0.09, 0.76 +- 0.06, and 0.58 +- 0.03 vs. 0.50 +- 0.05; all P < 0.05), (6) decreased protein levels of phospho-NF-kappaBp65 in lung homogenates and RLE-6TN cells (p-NF-kappaB/NF-kappaB: 0.47 +- 0.09 vs. 0.81 +- 0.13; 0.26 +- 0.07 vs. 0.79 +- 0.13; all P < 0.01), and (7) upregulated protein expression of phospho-AMPK in lung homogenates and RLE-6TN cells (p-AMPK/AMPK: 0.88 +- 0.05 vs. 0.36 +- 0.12; 0.93 +- 0.03 vs. 0.56 +- 0.15; all P < 0.01). Metformin 41-44 interleukin 1 beta Rattus norvegicus 484-492 31802883-0 2019 Lp-PLA2 Selective Inhibitor (Darapladib) Effect In Lowering The Expression Level Of IL-1B And IL-6 In The Renal At Type 2 Diabetes Mellitus. darapladib 29-39 interleukin 1 beta Rattus norvegicus 84-89 31802883-1 2019 Purpose: The aim of this study is to prove that type 2 diabetes mellitus can induce increasing inflammation marker in renal and that the provision of darapladib as Lp-LA2 Inhibitor agents can inhibit inflammation that were measured from the expression of IL-1B and IL-6- type cytokine in renal. darapladib 150-160 interleukin 1 beta Rattus norvegicus 255-260 31802883-6 2019 Results: The administration of darapladib can significantly decrease the expression of IL-1B- type cytokine (p ANOVA = 0.029, p < 0.005) measured in rats" renal both at weeks 8 and 16 in the T2DM group. darapladib 31-41 interleukin 1 beta Rattus norvegicus 87-92 31802848-8 2019 In addition, ILQ-treated MGN rats demonstrated anti-inflammatory effects by inhibiting NF-kappaB signaling pathway through decreased mRNA and protein expressions of NF-kappaB p65, IKKbeta, COX-2, iNOS, p38-MAPK, p-p38-MAPK, TNF-alpha, IL-1beta, IL-8, ICAM-1, E-selectin and VCAM-1 and reduced the nuclear translocation of NF-kappaB p65. neoisoliquiritin 13-16 interleukin 1 beta Rattus norvegicus 235-243 31618336-5 2019 While PTZ increased plasma CGRP, SP and IL-1beta concentrations, ghrelin reduced the increases evoked by PTZ. Pentylenetetrazole 6-9 interleukin 1 beta Rattus norvegicus 40-48 31646996-11 2019 Compared with the NBP group, tissue concentrations of inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-8, and interleukin-1beta, were significantly downregulated in the NBP-tadalafil group (P < 0.01; P < 0.05; P < 0.005, respectively). tadalafil 197-206 interleukin 1 beta Rattus norvegicus 134-151 31802922-13 2019 JMT and ALA also decreased IL-1beta, IL-18, and GSDMDC1 protein expression. Thioctic Acid 8-11 interleukin 1 beta Rattus norvegicus 27-35 31601968-6 2019 Compared with the control group, the level of IL-1beta and TNF-alpha in the hippocampus, spinal cord and DRG in the DNP + DP group was significantly increased, and DHM treatment could reduce the increase. dihydromyricetin 164-167 interleukin 1 beta Rattus norvegicus 46-54 32082922-8 2019 Results: Peroxynitrite injected groups at 24 and 48 h showed a statistically significant increase in interleukin 1 beta, tumor necrosis factor alpha, interleukin 4, interleukin 10 and malondialdehyde levels, which are accepted as mediators of the inflammatory process, compared to the control group. Peroxynitrous Acid 9-22 interleukin 1 beta Rattus norvegicus 101-148 31206774-3 2019 PCA suppressed MTX-mediated increases in interleukin-1beta, tumour necrosis factor alpha and caspase-3 activity in treated animals. Methotrexate 15-18 interleukin 1 beta Rattus norvegicus 41-58 31418433-2 2019 The substrate stainless steel (SS) was first coated with a polydopamine layer and subsequently grafted with poly(ethylene glycol) methacrylate brushes, onto which a sandwich immunosensor was modified for detection of IL-1beta. Stainless Steel 14-29 interleukin 1 beta Rattus norvegicus 217-225 31418433-5 2019 Furthermore, this device was validated by detection of IL-1beta in rat whole blood samples with greater concentrations observed in obese rats compared to control, and strong positive correlation between concentrations of IL-1beta and blood glucose. Glucose 240-247 interleukin 1 beta Rattus norvegicus 55-63 31418433-5 2019 Furthermore, this device was validated by detection of IL-1beta in rat whole blood samples with greater concentrations observed in obese rats compared to control, and strong positive correlation between concentrations of IL-1beta and blood glucose. Glucose 240-247 interleukin 1 beta Rattus norvegicus 221-229 31590658-8 2019 RESULTS: ACT treatment significantly inhibited the upregulation of inflammatory cytokines induced by IL-1beta in primary chondrocytes, including IL-6, IL-12, TNF-alpha and IFN-gamma. acteoside 9-12 interleukin 1 beta Rattus norvegicus 101-109 31590658-9 2019 ACT stimulation also enhanced the cell proliferation, while inhibited cell apoptosis in IL-1beta-treated chondrocytes. acteoside 0-3 interleukin 1 beta Rattus norvegicus 88-96 31590658-11 2019 Furthermore, ACT treatment inhibited IL-1beta-induced activation of JAK/STAT pathway. acteoside 13-16 interleukin 1 beta Rattus norvegicus 37-45 31476902-8 2019 At day 10, cardiac TLR4, Il (interleukin) 18, and Il1beta expression were increased in oxygen-exposed compared with room air controls. Oxygen 87-93 interleukin 1 beta Rattus norvegicus 50-57 30903708-8 2019 The administration of meloxicam and caffeic acid significantly protected livers against histopathological injury, significantly decreased plasma ALT, AST, and ALP levels, significantly decreased TNF-alpha, IL-6, IL-1beta levels, and oxidative stress. Meloxicam 22-31 interleukin 1 beta Rattus norvegicus 212-220 30903708-8 2019 The administration of meloxicam and caffeic acid significantly protected livers against histopathological injury, significantly decreased plasma ALT, AST, and ALP levels, significantly decreased TNF-alpha, IL-6, IL-1beta levels, and oxidative stress. caffeic acid 36-48 interleukin 1 beta Rattus norvegicus 212-220 31352322-9 2019 Consequently, Ac-YVAD-cmk reduced the release of mature IL-1beta/IL-18 in perihematoma, improved the behavioral performance, and alleviated microglia in perihematoma region in ICH rats. ac-yvad 14-21 interleukin 1 beta Rattus norvegicus 56-64 31306980-7 2019 The administration of COX-2 inhibitors, celecoxib and MPO-0029, significantly alleviated LSS-induced chronic mechanical allodynia and inhibited the mRNA expression of inflammatory mediators such as tnf-alpha, Il-1beta, il-6, and inos. Celecoxib 40-49 interleukin 1 beta Rattus norvegicus 209-217 31356536-9 2019 Melatonin infusion in PVN reduced LVEDV, NE, ROS, NOX2, NOX4, IL-1beta, and NF-kappaB activity, and increased LVEF, LVFS, Cu/Zn-SOD, and IL-10. Melatonin 0-9 interleukin 1 beta Rattus norvegicus 62-70 31325725-8 2019 In the present research, neuropathic pain induced Nrf2 and HO-1 expression in the microglial cells of the spinal cord; Nrf2 and HO-1 were necessary to alleviate the hyperalgesia of CCI-induced rats; NaHS mitigated the hyperalgesia and allodynia induced by the CCI operation; and NaHS mitigated the excessive release of the cytokines TNF-alpha, IL-1beta, IL-6 and HMGB1 via the Nrf2/HO-1 pathway in the microglial cells of the spinal cord. CCI 181-184 interleukin 1 beta Rattus norvegicus 344-352 31325725-8 2019 In the present research, neuropathic pain induced Nrf2 and HO-1 expression in the microglial cells of the spinal cord; Nrf2 and HO-1 were necessary to alleviate the hyperalgesia of CCI-induced rats; NaHS mitigated the hyperalgesia and allodynia induced by the CCI operation; and NaHS mitigated the excessive release of the cytokines TNF-alpha, IL-1beta, IL-6 and HMGB1 via the Nrf2/HO-1 pathway in the microglial cells of the spinal cord. sodium bisulfide 199-203 interleukin 1 beta Rattus norvegicus 344-352 31111559-5 2019 The inflammatory chondrocytes induced by 10 ng/mL IL-1beta were observed and identified by toluidine blue and COL II immunocytochemical stainings. Tolonium Chloride 91-105 interleukin 1 beta Rattus norvegicus 50-58 31473513-7 2019 Curcumin attenuated VSMC migration, inhibited nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) expression and reduced interleukin (IL)-1beta concentration in VSMC of SHR, which were similar to the effects of NLRP3 knockdown on IL-1beta concentration and VSMC migration. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 143-165 31473513-7 2019 Curcumin attenuated VSMC migration, inhibited nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) expression and reduced interleukin (IL)-1beta concentration in VSMC of SHR, which were similar to the effects of NLRP3 knockdown on IL-1beta concentration and VSMC migration. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 252-260 31473513-9 2019 In another in vitro model of rat VSMC migration, curcumin also inhibited angiotensin II-induced VSMC migration, NFkappaB activation, NLRP3 expression and IL-1beta production. Curcumin 49-57 interleukin 1 beta Rattus norvegicus 154-162 31719759-12 2019 GYY4137 attenuated the IL-1beta-induced Prx4 secretion from hepatocytes. GYY 4137 0-7 interleukin 1 beta Rattus norvegicus 23-31 31561455-4 2019 Capsaicin-induced IL-1beta, COX-2, IL-6, caspase-1, and NGF upregulation on day 3 and 7, while NALP1 and TNF-alpha upregulation was observed on day 7. Capsaicin 0-9 interleukin 1 beta Rattus norvegicus 18-26 31311447-10 2019 Moreover, UTI inhibited the expression of TNF-alpha, IL-1beta and Abeta induced by isoflurane in rat brain harvested at 16 h after isoflurane exposure. Isoflurane 83-93 interleukin 1 beta Rattus norvegicus 53-61 31195405-5 2019 RESULTS: Neurons treated with UCB showed increased caspase-1 activity without the secretion of interleukin (IL)-1beta and IL-18, and caspase-1 was significantly inhibited by pretreatment with VX-765. belnacasan 192-198 interleukin 1 beta Rattus norvegicus 95-117 31195405-8 2019 CONCLUSION: Bilirubin-induced neuronal injury involves the activation of caspase-1 and NF-kappaB, leading to membrane leakage, independently of IL-1beta and IL-18. Bilirubin 12-21 interleukin 1 beta Rattus norvegicus 144-152 31561418-7 2019 In addition, MTX upregulated renal iNOS, COX-2, TNF-alpha, IL-1beta, Bax, caspase-9, and caspase-3, and decreased Bcl-2, Nrf2, and HO-1. Methotrexate 13-16 interleukin 1 beta Rattus norvegicus 59-67 31432179-3 2019 In an in vitro model of cerebral ischemia-reperfusion, the downregulation of miRNA-451 increased inflammation, demonstrated by increased levels of tumor necrosis factor alpha, interleukin (IL)-1b, IL-6 and IL-18. mirna-451 77-86 interleukin 1 beta Rattus norvegicus 176-195 31571883-13 2019 Moreover, galuteolin also significantly reduced the levels of pro-inflammatory factors IL-1beta and TNF-alpha in the cerebral infarction tissues. luteolin-7-glucoside 10-20 interleukin 1 beta Rattus norvegicus 87-95 31692634-10 2019 Results: Treatments with MC1568, ACY1083, MC1568+ACY1083, and VPA were associated with decreased IL-1beta levels in the intestine and serum compared with NS. MC1568 25-31 interleukin 1 beta Rattus norvegicus 97-105 31692634-10 2019 Results: Treatments with MC1568, ACY1083, MC1568+ACY1083, and VPA were associated with decreased IL-1beta levels in the intestine and serum compared with NS. MC1568 42-56 interleukin 1 beta Rattus norvegicus 97-105 31692634-10 2019 Results: Treatments with MC1568, ACY1083, MC1568+ACY1083, and VPA were associated with decreased IL-1beta levels in the intestine and serum compared with NS. Valproic Acid 62-65 interleukin 1 beta Rattus norvegicus 97-105 31228458-8 2019 Moreover, VA concentration -dependently inhibited IL-1beta induced production of High-mobility group box 1 (HMGB1), a classic damage-associated molecular pattern (DAMP) molecule with strong pro-inflammatory effects in OA. Vanillic Acid 10-12 interleukin 1 beta Rattus norvegicus 50-58 31527618-6 2019 In serum, levosimendan decreased the level of tumour necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and nitric oxide (NO). Simendan 10-22 interleukin 1 beta Rattus norvegicus 76-98 31527618-8 2019 In primary cultured rat hepatocytes stimulated by IL-1beta, levosimendan suppressed NO production by inhibiting iNOS promoter activity and stability of its mRNA. Simendan 60-72 interleukin 1 beta Rattus norvegicus 50-58 31632569-10 2019 MR markedly attenuated the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1 beta (IL-1beta). morroniside 0-2 interleukin 1 beta Rattus norvegicus 103-121 31632569-10 2019 MR markedly attenuated the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1 beta (IL-1beta). morroniside 0-2 interleukin 1 beta Rattus norvegicus 123-131 31551683-15 2019 The increased interleukin-6 (IL-6), IL-1beta, and tumor necrosis factor-alpha (TNF-alpha) secretion in CCI + NaCl group was lowered by HS and SP + HS. Sodium Chloride 109-113 interleukin 1 beta Rattus norvegicus 36-44 31228805-6 2019 It was found that the SMH loaded ISH could benefit AA-rats by suppressing the level of IL-1beta in comparison to SMH solutions. sinomenine 22-25 interleukin 1 beta Rattus norvegicus 87-95 31211985-0 2019 Liquiritigenin inhibits IL-1beta-induced inflammation and cartilage matrix degradation in rat chondrocytes. liquiritigenin 0-14 interleukin 1 beta Rattus norvegicus 24-32 31211985-5 2019 Our results showed that LG could inhibit the IL-1beta-induced expression of nitic oxide (NO) and prostaglandin E2 (PGE2). nitic oxide 76-87 interleukin 1 beta Rattus norvegicus 45-53 31211985-5 2019 Our results showed that LG could inhibit the IL-1beta-induced expression of nitic oxide (NO) and prostaglandin E2 (PGE2). Dinoprostone 97-113 interleukin 1 beta Rattus norvegicus 45-53 31211985-5 2019 Our results showed that LG could inhibit the IL-1beta-induced expression of nitic oxide (NO) and prostaglandin E2 (PGE2). Dinoprostone 115-119 interleukin 1 beta Rattus norvegicus 45-53 31431516-9 2019 FM0807 also potently attenuated the increase in the expression of inflammatory factors TNF-alpha, IL-6 and IL-1beta in synovial fluid, while IL-10 levels were also elevated. fm0807 0-6 interleukin 1 beta Rattus norvegicus 107-115 30897968-2 2019 In DR patients, antioxidant defence is disrupted, and production of reactive oxygen species and pro-inflammatory cytokines such as interleukin 1beta (IL-1beta) and tumour necrosis factor alpha (TNF-alpha) increases. Reactive Oxygen Species 68-91 interleukin 1 beta Rattus norvegicus 150-158 30897968-3 2019 Taxifolin has been reported to suppress reactive oxygen species, IL-1beta and TNF-alpha production. taxifolin 0-9 interleukin 1 beta Rattus norvegicus 65-73 30897968-13 2019 Results: MDA, IL-1beta and TNF-alpha levels were significantly increased in blood samples of DC group rats with hyperglycemia induced by alloxan compared with NC group (p < 0.0001), and decreased in the TAX group compared with the DC group (p < 0.0001). Deoxycytidine 93-95 interleukin 1 beta Rattus norvegicus 14-22 31278647-4 2019 In addition, COL caused significant increase in amyloid beta peptide 1-42 (beta, amyloid 1-42) interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNFalpha), cyclooxygenase-2 (COX-2) and TNF-alpha genes expression in the brain, and glial fibrillary acidic protein (GFAP) in cortical astrocytes in the brain cortex.Treatment with SIFE (80 mg/kg b.wt) daily for 14 days followed by a single dose of COL significantly reduced the elevated oxidative stress parameters and restored the reduced antioxidant activities. Colchicine 13-16 interleukin 1 beta Rattus norvegicus 95-112 31142131-10 2019 Contrastingly, caffeic acid lowered 1,3-dichloro-2-propanol-mediated increase in the levels of nuclear factor-kappa B (NF-kappaB), tumour necrosis factor-alpha, interleukin-1beta (IL-1beta) and IL-6. caffeic acid 15-27 interleukin 1 beta Rattus norvegicus 161-178 31142131-10 2019 Contrastingly, caffeic acid lowered 1,3-dichloro-2-propanol-mediated increase in the levels of nuclear factor-kappa B (NF-kappaB), tumour necrosis factor-alpha, interleukin-1beta (IL-1beta) and IL-6. caffeic acid 15-27 interleukin 1 beta Rattus norvegicus 180-188 31132876-6 2019 Wog therapy reduced the Cd-influenced generation of inflammatory mediators, inclusive of tumor necrosis factor alpha, interleukin 6, and interleukin 1 beta. Cadmium 24-26 interleukin 1 beta Rattus norvegicus 137-155 31142131-10 2019 Contrastingly, caffeic acid lowered 1,3-dichloro-2-propanol-mediated increase in the levels of nuclear factor-kappa B (NF-kappaB), tumour necrosis factor-alpha, interleukin-1beta (IL-1beta) and IL-6. 1,3-dichloro-2-propanol 36-59 interleukin 1 beta Rattus norvegicus 161-178 31142131-10 2019 Contrastingly, caffeic acid lowered 1,3-dichloro-2-propanol-mediated increase in the levels of nuclear factor-kappa B (NF-kappaB), tumour necrosis factor-alpha, interleukin-1beta (IL-1beta) and IL-6. 1,3-dichloro-2-propanol 36-59 interleukin 1 beta Rattus norvegicus 180-188 31356540-10 2019 Eliminating ROS with N-acetylcysteine or preinject CY into rat jugular vein reduces the expression of IL-6, TNF-a, and, especially, IL-1b in an in vivo I/R model. Reactive Oxygen Species 12-15 interleukin 1 beta Rattus norvegicus 132-137 30900747-10 2019 RESULTS: TNF-alpha, IL-1beta, MMP-1, MMP-2 levels were significantly lower in AP + ALA group compared with AP group (P < 0.05). ap + ala 78-86 interleukin 1 beta Rattus norvegicus 20-28 31176023-7 2019 TNF-alpha and IL-1beta gene expression significantly down regulated EGCG 50 and combined with PENG compared to the otitis media group. epigallocatechin gallate 68-72 interleukin 1 beta Rattus norvegicus 14-22 31356540-10 2019 Eliminating ROS with N-acetylcysteine or preinject CY into rat jugular vein reduces the expression of IL-6, TNF-a, and, especially, IL-1b in an in vivo I/R model. Acetylcysteine 21-37 interleukin 1 beta Rattus norvegicus 132-137 31356540-10 2019 Eliminating ROS with N-acetylcysteine or preinject CY into rat jugular vein reduces the expression of IL-6, TNF-a, and, especially, IL-1b in an in vivo I/R model. Cyclophosphamide 51-53 interleukin 1 beta Rattus norvegicus 132-137 31254582-8 2019 Furthermore, phosphine significantly induced phosphorylation of IkappaB, NF-kappaB and up-regulation of TNF-alpha, IL-1beta, IL-6, and ICAM-1 expression. phosphine 13-22 interleukin 1 beta Rattus norvegicus 115-123 31257518-10 2019 Additionally, TAK242 significantly inhibited the IRI-associated inflammatory response, indicated by the decreased expression of TLR4, interleukin (IL)-1beta, IL-6 and cyclooxygenase 2 at the mRNA and protein levels (P<0.05). ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 14-20 interleukin 1 beta Rattus norvegicus 134-156 31344482-6 2019 After glucose stimulation, c-myc promoted the releases of IL-1beta, TNF-alpha and IL-6. Glucose 6-13 interleukin 1 beta Rattus norvegicus 58-66 31344482-10 2019 Under glucose treatment, c-myc facilitated the release of Muller cells-derived IL-1beta, TNF-alpha and IL-6 by regulating MIAT/TXNIP pathway. Glucose 6-13 interleukin 1 beta Rattus norvegicus 79-87 31362009-6 2019 In addition, Lut and GA produced significant reversal of CoCl2-induced elevation in levels of serum Interleukin 1 beta (IL-1beta) and Tumor necrosis factor (TNFalpha). Luteolin 13-16 interleukin 1 beta Rattus norvegicus 100-118 31524234-6 2019 Furthermore, formononetin and AG490 attenuated the inflammatory response in HUVECs by downregulating the protein and mRNA expression levels of interleukin (IL)-1beta and intercellular adhesion molecule 1 (ICAM-1). formononetin 13-25 interleukin 1 beta Rattus norvegicus 143-165 31524234-6 2019 Furthermore, formononetin and AG490 attenuated the inflammatory response in HUVECs by downregulating the protein and mRNA expression levels of interleukin (IL)-1beta and intercellular adhesion molecule 1 (ICAM-1). alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 30-35 interleukin 1 beta Rattus norvegicus 143-165 31524234-8 2019 Notably, formononetin was able to reverse the abnormal levels of phosphorylated (p)-JAK2, p-STAT3, IL-1beta, ICAM-1 and NO induced by cotreatment with high glucose and IL-6, an agonist of the JAK/STAT signaling pathway. formononetin 9-21 interleukin 1 beta Rattus norvegicus 99-107 31362009-6 2019 In addition, Lut and GA produced significant reversal of CoCl2-induced elevation in levels of serum Interleukin 1 beta (IL-1beta) and Tumor necrosis factor (TNFalpha). Gallic Acid 21-23 interleukin 1 beta Rattus norvegicus 100-118 31362009-6 2019 In addition, Lut and GA produced significant reversal of CoCl2-induced elevation in levels of serum Interleukin 1 beta (IL-1beta) and Tumor necrosis factor (TNFalpha). cobaltous chloride 57-62 interleukin 1 beta Rattus norvegicus 100-118 30986405-7 2019 A significant down-regulation of IL-1beta, IL-6 and TNF-alpha but not HMGB1 was found in BoxA-treated compared to untreated animals. boxa 89-93 interleukin 1 beta Rattus norvegicus 33-41 31611754-9 2019 Hesperidin significantly inhibited BLM-induced down-regulated lung Nrf2 and HO-1 as well as up-regulated TNF-alpha, IL-1beta, IL-6, collagen-1, TGF-beta, and Smad-3 mRNA expressions. Hesperidin 0-10 interleukin 1 beta Rattus norvegicus 116-124 31611754-9 2019 Hesperidin significantly inhibited BLM-induced down-regulated lung Nrf2 and HO-1 as well as up-regulated TNF-alpha, IL-1beta, IL-6, collagen-1, TGF-beta, and Smad-3 mRNA expressions. Bleomycin 35-38 interleukin 1 beta Rattus norvegicus 116-124 31611754-12 2019 Hesperidin alleviates BLM-induced IPF via inhibition of TGF-beta1/Smad3/AMPK and IkappaBalpha/NF-kappaB pathways which in turn ameliorate the modulation of oxido-inflammatory markers (Nrf2 and HO-1) and pro-inflammatory markers (TNF-alpha, IL-1beta, and IL-6) to reduce collagen deposition during pulmonary fibrosis. Hesperidin 0-10 interleukin 1 beta Rattus norvegicus 240-248 31611754-12 2019 Hesperidin alleviates BLM-induced IPF via inhibition of TGF-beta1/Smad3/AMPK and IkappaBalpha/NF-kappaB pathways which in turn ameliorate the modulation of oxido-inflammatory markers (Nrf2 and HO-1) and pro-inflammatory markers (TNF-alpha, IL-1beta, and IL-6) to reduce collagen deposition during pulmonary fibrosis. Bleomycin 22-25 interleukin 1 beta Rattus norvegicus 240-248 31534463-9 2019 Moreover, the expression of inflammatory factors TNF-alpha, IL-1beta, and IL-6 was significantly reduced in the treated DHI group. dehydrosoyasaponin I 120-123 interleukin 1 beta Rattus norvegicus 60-68 31555091-9 2019 Chronic stress and dexamethasone both increased Iba-1 expression and ROS formation and also elevated levels of NF-kappaB, NLRP3, cleaved caspase-1, IL-1beta and IL-18. Dexamethasone 19-32 interleukin 1 beta Rattus norvegicus 148-156 31555091-10 2019 After use of the NF-kappaB inhibitor BAY 117082 and knocked out NLRP3 in vitro decreased ROS formation and the expression of Iba-1, NF-kappaB and NLRP3 as well as levels of cleaved caspase-1, IL-1beta and IL-18. 3-(4-methylphenylsulfonyl)-2-propenenitrile 37-47 interleukin 1 beta Rattus norvegicus 192-200 31686780-9 2019 Esomeprazole also reduced the levels of MPO (myeloperoxidase), tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta according to its anti-inflammatory effects. Esomeprazole 0-12 interleukin 1 beta Rattus norvegicus 101-123 31427974-0 2019 Luteoloside Inhibits IL-1beta-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration. luteolin-7-glucoside 0-11 interleukin 1 beta Rattus norvegicus 21-29 31399002-6 2021 Also, interleukin-1beta (IL-1beta), IL-6, and tumour necrosis factor-alpha (TNF-alpha) were elevated in the PAG of STZ rats and their receptors (IL-1R, IL-6R, and TNFR1) were upregulated. Streptozocin 115-118 interleukin 1 beta Rattus norvegicus 6-23 31399002-6 2021 Also, interleukin-1beta (IL-1beta), IL-6, and tumour necrosis factor-alpha (TNF-alpha) were elevated in the PAG of STZ rats and their receptors (IL-1R, IL-6R, and TNFR1) were upregulated. Streptozocin 115-118 interleukin 1 beta Rattus norvegicus 25-33 31427974-7 2019 Furthermore, we found increased collagen II and aggrecan expression and reduced MMP13 and ADAMTS5 expression in luteoloside-treated NP cells in the presence of IL-1beta. luteolin-7-glucoside 112-123 interleukin 1 beta Rattus norvegicus 160-168 31175933-5 2019 Furthermore, micro-injection of the NF-kappaB inhibitor pyrrolidine dithiocarbamate into PVN in MI rats, significantly inhibited the activation of NF-kappaB and further reduced the expression of IL-1beta and NGF in the PVN, finally blunting sympathetic hyperinnervation in the heart, moreover, the blockade of NF-kappaB in the PVN reduced the incidence of ventricular arrhythmias (VAs). pyrrolidine dithiocarbamic acid 56-83 interleukin 1 beta Rattus norvegicus 195-203 31132357-5 2019 The results suggested metformin decreased the inflammatory response by reducing the expression of proinflammatory cytokines (TNF-alpha, IL-1beta and IL-6), myeloperoxidase activity, and malondialdehyde levels. Metformin 22-31 interleukin 1 beta Rattus norvegicus 136-144 31427974-5 2019 We found that luteoloside maintains cell morphology and inhibits apoptosis (indicated by the reduced expression of cleaved caspase 3) in IL-1beta-treated nucleus pulposus (NP) cells. luteolin-7-glucoside 14-25 interleukin 1 beta Rattus norvegicus 137-145 31032997-0 2019 Berberine inhibits the interleukin-1 beta-induced inflammatory response via MAPK downregulation in rat articular chondrocytes. Berberine 0-9 interleukin 1 beta Rattus norvegicus 23-41 30792486-7 2019 Administration of minocycline significantly decreased the infarct size, alleviated myocardial cell damage, elevated left ventricle ejection fraction, and left ventricle fractional shortening following I/R injury along with significantly decreased pro-inflammatory cytokine IL-1beta and monocyte chemoattractant protein-1 (MCP-1) levels in heart tissue. Minocycline 18-29 interleukin 1 beta Rattus norvegicus 273-281 31103702-7 2019 Additionally, cisplatin-injected rats showed a significant rise in tissue levels of IL-1beta, TNF-alpha, NF-kB, and caspase-3 enzymatic activity. Cisplatin 14-23 interleukin 1 beta Rattus norvegicus 84-92 31158461-8 2019 RESULTS: The infarct volume was significantly reduced and white matter damage was also significantly alleviated in the melatonin group as compared with the MCAO group (P < 0.05), and there were more TLR4+, NF-kappaB+ and IL-1beta+ cells in the MCAO group compared with the melatonin group (P < 0.01). Melatonin 119-128 interleukin 1 beta Rattus norvegicus 225-233 31158461-11 2019 CONCLUSIONS: In summary, melatonin could promote the proliferation of endogenous OPCs and suppress the expression of IL-1beta protein via inhibiting TLR4/NF-kappaB signaling, thus alleviate the white matter damage in focal cerebral ischemic rats. Melatonin 25-34 interleukin 1 beta Rattus norvegicus 117-125 30937838-6 2019 These data suggest that formononetin may suppress IL-1beta-induced severe catabolic effects and osteoarthritic condition. formononetin 24-36 interleukin 1 beta Rattus norvegicus 50-58 31289794-6 2019 FA inhibited MTX-induced inflammasome activation as showed by the decreased phosphorylation of NF-kappaB, and expression of NLRP3, caspase-1 and IL-1beta. Methotrexate 13-16 interleukin 1 beta Rattus norvegicus 145-153 30937838-0 2019 Formononetin Antagonizes the Interleukin-1beta-Induced Catabolic Effects Through Suppressing Inflammation in Primary Rat Chondrocytes. formononetin 0-12 interleukin 1 beta Rattus norvegicus 29-46 30937838-1 2019 In the present study, we demonstrated the anti-catabolic effects of formononetin, a phytoestrogen derived from herbal plants, against interleukin-1beta (IL-1beta)-induced severe catabolic effects in primary rat chondrocytes and articular cartilage. formononetin 68-80 interleukin 1 beta Rattus norvegicus 134-151 31368542-3 2019 Fisetin administration to CS-exposed rats resulted in a significant reduction in neutrophils and macrophages in bronchoalveolar lavage fluid as well as malondialdehyde, 3-nitrotyrosine, 8-isoprostane, tumor necrosis factor-alpha, interleukin-1beta, granulocyte macrophage-colony stimulating factor, interleukin-4, and interleukin-10 levels in lung tissues compared to those in CS-exposed rats not treated with fisetin. fisetin 0-7 interleukin 1 beta Rattus norvegicus 230-247 30937838-1 2019 In the present study, we demonstrated the anti-catabolic effects of formononetin, a phytoestrogen derived from herbal plants, against interleukin-1beta (IL-1beta)-induced severe catabolic effects in primary rat chondrocytes and articular cartilage. formononetin 68-80 interleukin 1 beta Rattus norvegicus 153-161 30937838-3 2019 Furthermore, formononetin effectively antagonized the IL-1beta-induced catabolic effects including the decrease in proteoglycan content, suppression of pericellular matrix formation, and loss of proteoglycan through the decreased expression of cartilage-degrading enzymes like matrix metalloproteinase (MMP)-13, MMP-1, and MMP-3 in primary rat chondrocytes. formononetin 13-25 interleukin 1 beta Rattus norvegicus 54-62 30937838-4 2019 Moreover, catabolic oxidative stress mediators like nitric oxide, inducible nitric oxide synthase, cyclooxygenase-2, and prostaglandin E2 were significantly downregulated by formononetin in primary rat chondrocytes treated with IL-1beta. formononetin 174-186 interleukin 1 beta Rattus norvegicus 228-236 31378915-8 2019 At the same time, alamandine can significantly reduce the levels of TNF-alpha, IL-1beta, IL-6, and NO. alamandine 18-28 interleukin 1 beta Rattus norvegicus 79-87 31368542-3 2019 Fisetin administration to CS-exposed rats resulted in a significant reduction in neutrophils and macrophages in bronchoalveolar lavage fluid as well as malondialdehyde, 3-nitrotyrosine, 8-isoprostane, tumor necrosis factor-alpha, interleukin-1beta, granulocyte macrophage-colony stimulating factor, interleukin-4, and interleukin-10 levels in lung tissues compared to those in CS-exposed rats not treated with fisetin. Cesium 26-28 interleukin 1 beta Rattus norvegicus 230-247 31173182-9 2019 Furthermore, puerarin administration decreased the expression levels of retinal vascular endothelial growth factor and interleukin-1beta and increased the mRNA expression levels of Nrf2 and HO-1, thus inhibiting oxidative stress. puerarin 13-21 interleukin 1 beta Rattus norvegicus 119-136 30910525-6 2019 Further, 10 muM imatinib increased mRNA expression of TGFB1 7-fold, (p < 0.01), IL6 6-fold (p < 0.01), and IL1B 7-fold (p < 0.05) and reduced PDGFD 15-fold (p < 0.01); whereas sunitinib specifically reduced IL1B mRNA expression 17-fold (p < 0.01). Imatinib Mesylate 16-24 interleukin 1 beta Rattus norvegicus 107-111 31257459-0 2019 17beta-Estradiol protects against interleukin-1beta-induced apoptosis in rat nucleus pulposus cells via the mTOR/caspase-3 pathway. Estradiol 0-16 interleukin 1 beta Rattus norvegicus 34-51 31257459-2 2019 In our previous studies, 17beta-estradiol (E2) was demonstrated to protect rat NPCs from interleukin-1beta (IL-1beta)-induced apoptosis via the PI3K/Akt signaling pathway. Estradiol 25-41 interleukin 1 beta Rattus norvegicus 89-106 31257459-2 2019 In our previous studies, 17beta-estradiol (E2) was demonstrated to protect rat NPCs from interleukin-1beta (IL-1beta)-induced apoptosis via the PI3K/Akt signaling pathway. Estradiol 43-45 interleukin 1 beta Rattus norvegicus 89-106 31197747-9 2019 Metformin and glyburide pretreatment normalized the LPS-induced IL-1beta secretion in the control and diabetic cultures. Metformin 0-9 interleukin 1 beta Rattus norvegicus 64-72 31197747-9 2019 Metformin and glyburide pretreatment normalized the LPS-induced IL-1beta secretion in the control and diabetic cultures. Glyburide 14-23 interleukin 1 beta Rattus norvegicus 64-72 30910525-6 2019 Further, 10 muM imatinib increased mRNA expression of TGFB1 7-fold, (p < 0.01), IL6 6-fold (p < 0.01), and IL1B 7-fold (p < 0.05) and reduced PDGFD 15-fold (p < 0.01); whereas sunitinib specifically reduced IL1B mRNA expression 17-fold (p < 0.01). Imatinib Mesylate 16-24 interleukin 1 beta Rattus norvegicus 207-211 31085237-9 2019 The levels of IL-1beta were remarkably increased in both calcified VSMCs and aortas of uremic rats, while puerarin treatment markedly decreased the expression of IL-1beta. puerarin 106-114 interleukin 1 beta Rattus norvegicus 162-170 31413946-0 2019 Renal and testicular up-regulation of pro-inflammatory chemokines (RANTES and CCL2) and cytokines (TNF-alpha, IL-1beta, IL-6) following acute edible camphor administration is through activation of NF-kB in rats. Camphor 149-156 interleukin 1 beta Rattus norvegicus 110-118 31413946-5 2019 Compared with control, levels of tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta) and interleukin 6 (IL-6) were significantly increased kidney and testes by 2000 and 4000 mg/kg body weight, while interleukin 10 (IL-10) was only significantly increased by 1000 mg/kg body weight of camphor in both tissues. Camphor 303-310 interleukin 1 beta Rattus norvegicus 94-102 31360147-13 2019 In conclusion, berberine exerts its neuroprotective effect against n-STZ-induced diabetic peripheral neuropathy via modulation of pro-inflammatory cytokines (TNF alpha, IL-1beta, and IL-6), oxido-nitrosative stress, BDNF, IGF-1, PPAR-gamma, and AMPK expression to ameliorate impaired allodynia, hyperalgesia, and nerve conduction velocity during T2DM. Berberine 15-24 interleukin 1 beta Rattus norvegicus 169-177 31085237-10 2019 In addition, we found that puerarin reduced IL-1beta possibly through targeting NLRP3/Caspase1/IL-1beta and NF-kappaB signaling pathways and inhibiting the generation of reactive oxygen species. puerarin 27-35 interleukin 1 beta Rattus norvegicus 44-52 31085237-10 2019 In addition, we found that puerarin reduced IL-1beta possibly through targeting NLRP3/Caspase1/IL-1beta and NF-kappaB signaling pathways and inhibiting the generation of reactive oxygen species. puerarin 27-35 interleukin 1 beta Rattus norvegicus 95-103 31002915-6 2019 Bone cancer resulted in the activation of astrocytes and microglia in the SDH through the upregulation of mitogen-activated protein kinase (MAPK) pathways, which was accompanied by an over-expression of pro-inflammatory cytokines, including TNF-alpha, IL-1beta, and IL-6. sdh 74-77 interleukin 1 beta Rattus norvegicus 252-260 31002778-4 2019 Furthermore, ginsenoside Rg1 suppressed the expression of IL-1beta, IL-6,TNF-alpha,NF-kappaB and G6Pase, however, p-Akt was up-regulated. Ginsenosides 13-24 interleukin 1 beta Rattus norvegicus 58-66 31308727-10 2019 The enhancement of p-JAK2, p-STAT3, pro-inflammatory cytokines IL-1beta and IL-6 protein levels induced by SNI were also observed. sni 107-110 interleukin 1 beta Rattus norvegicus 63-71 31331435-5 2019 Cd deposition resulted in lung inflammation characterized by a dose-dependent IL-1beta increase in lung homogenates, increased TNF levels at both doses, and IL-6 stimulation at low doses with inhibition observed at higher doses. Cadmium 0-2 interleukin 1 beta Rattus norvegicus 78-86 31005664-5 2019 Intrathecal administration of RS504393 (a CCR2 antagonist) markedly reduced the zymosan-induced thermal and mechanical hyperalgesia accompanied with reduced expression in the spinal cord of c-Fos, CD11b, phosphorylated p38 mitogen activated protein kinases (p-p38), and interleukin-1beta. RS 504393 30-38 interleukin 1 beta Rattus norvegicus 270-287 31333648-14 2019 ALA improved the cardiac and renal functions, downregulated the expression levels of interleukin-1beta, tumor necrosis factor-alpha, and inducible nitric oxide synthase in the myocardium and small intestine of septic rats. Thioctic Acid 0-3 interleukin 1 beta Rattus norvegicus 85-131 29537332-6 2019 The treatment with zingerone markedly abrogated ROS levels, inhibited the NF-kB activation and considerably reduced level of other downstream inflammatory molecules (TNF-alpha, IL-6, IL-1beta), furthermore, zingerone treatment improved renal functioning by significantly decreasing the levels of kidney toxicity markers KIM-1, BUN, creatinine, and LDH and suppressed TGF-beta. zingerone 19-28 interleukin 1 beta Rattus norvegicus 183-191 31034945-7 2019 Interestingly, baclofen pretreatment inhibited SGC activation and IL-1beta production, however, preserved the decreased expression of GABAB receptors in SGCs activated by CFA in vivo and LPS in vitro. Baclofen 15-23 interleukin 1 beta Rattus norvegicus 66-74 30970221-11 2019 Moreover, DSAP-MSC transplantation down-regulated the expression of IL-6 and IL-1beta and up-regulated the level of VEGF and HGF. dsap 10-14 interleukin 1 beta Rattus norvegicus 77-85 30825296-11 2019 The analysis of protein expression by western blotting revealed that minocycline treatment along with OECs transplantation further decreased the level of IL-1beta, TNF-alpha, caspase-3, and the oxidative stress as compared with when minocycline or OECs transplantation was used alone. Minocycline 69-80 interleukin 1 beta Rattus norvegicus 154-162 31073849-9 2019 Sitagliptin produced a significant increase in the expression of hepatic inflammatory markers (Tnfa, Il1b, and Mcp1) and a corresponding increase in serum TNFalpha and IL-1beta in rats on the high-Cho diet, but it had no effect on rats on the control diet. Sitagliptin Phosphate 0-11 interleukin 1 beta Rattus norvegicus 101-105 31073849-9 2019 Sitagliptin produced a significant increase in the expression of hepatic inflammatory markers (Tnfa, Il1b, and Mcp1) and a corresponding increase in serum TNFalpha and IL-1beta in rats on the high-Cho diet, but it had no effect on rats on the control diet. Sitagliptin Phosphate 0-11 interleukin 1 beta Rattus norvegicus 168-176 31091348-6 2019 Lut therapy reduced the BPA-influenced generation of inflammatory mediators, inclusive of tumor necrosis factor alpha, interleukin 6, and interleukin 1 beta. bisphenol A 24-27 interleukin 1 beta Rattus norvegicus 138-156 30920066-5 2019 Furthermore, the increase in levels of nitric oxide, tumor necrosis factor-alpha and interleukin-1beta, myeloperoxidase and caspase-3 activities as well as histological lesions was more pronounced in the liver and kidney of rats coexposed to DEN and fluoride. Diethylnitrosamine 242-245 interleukin 1 beta Rattus norvegicus 85-102 31142603-7 2019 Our data show that metformin increased IL-10 and IDO expression in Ad-hMSCs and decreased high-mobility group box 1 protein, IL-1beta, and IL-6 expression. Metformin 19-28 interleukin 1 beta Rattus norvegicus 125-133 31142603-9 2019 In cocultures, metformin-stimulated Ad-hMSCs inhibited the mRNA expression of RUNX2, COL X, VEGF, MMP1, MMP3, and MMP13 in IL-1beta-stimulated OA chondrocytes and increased the expression of TIMP1 and TIMP3. Metformin 15-24 interleukin 1 beta Rattus norvegicus 123-131 30892121-5 2019 Clarithromycin significantly reduced IL-1b and TNF-a and significantly increased IL-10 levels. Clarithromycin 0-14 interleukin 1 beta Rattus norvegicus 37-42 30927681-14 2019 On the basis of this research, we concluded that CP/CPPS increases susceptibility to lindane-induced seizures in rats associated with increased level of IL-1beta and IL-6 in the cortex and thalamus. Hexachlorocyclohexane 85-92 interleukin 1 beta Rattus norvegicus 153-161 30511399-6 2019 Moreover, in both the balloon injury-induced rat sera and the LPS-treated VSMCs, DHA significantly inhibited proinflammatory cytokines, including interleukin-1beta, tumor necrosis factor-alpha, and matrix metalloproteinase-1. artenimol 81-84 interleukin 1 beta Rattus norvegicus 146-163 30592970-7 2019 In addition, Sildenafil treatment of MMI in aged rats significantly decreases Beclin1 expression and inflammatory factors Monocyte chemoattractant protein-1 and Interleukin-1beta expression in brain. Sildenafil Citrate 13-23 interleukin 1 beta Rattus norvegicus 161-178 31115561-3 2019 The downregulation of miRNA-22 upregulated the expression of inflammatory factors [including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and IL-18]. mirna-22 22-30 interleukin 1 beta Rattus norvegicus 122-144 31115524-5 2019 Costunolide decreased the interleukin (IL)-1beta-induced upregulation of matrix metalloproteinases (MMPs), inducible nitric oxide synthase, cyclooxygenase-2 and IL-6, and increased the expression of collagen II and transcription factor SOX-9, which were inhibited by IL-1beta. costunolide 0-11 interleukin 1 beta Rattus norvegicus 26-48 31115524-5 2019 Costunolide decreased the interleukin (IL)-1beta-induced upregulation of matrix metalloproteinases (MMPs), inducible nitric oxide synthase, cyclooxygenase-2 and IL-6, and increased the expression of collagen II and transcription factor SOX-9, which were inhibited by IL-1beta. costunolide 0-11 interleukin 1 beta Rattus norvegicus 267-275 31115524-6 2019 Costunolide significantly decreased p65 phosphorylation induced by IL-1beta and the translocation of p65 into the nucleus of rat chondrocytes, as observed by western blot analysis and immunofluorescence staining. costunolide 0-11 interleukin 1 beta Rattus norvegicus 67-75 31115524-7 2019 In addition, activation of the Wnt/beta-catenin signaling pathway was inhibited by costunolide, as demonstrated by the level of activation of beta-catenin and the transfer of beta-catenin into the nucleus induced by IL-1beta. costunolide 83-94 interleukin 1 beta Rattus norvegicus 216-224 31293382-7 2019 Also, treatment with 2-BFI significantly reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine interleukin (IL)-1beta secretion, which is related to nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation after TBI. 2-(2-benzofuranyl)-2-imidazoline 21-26 interleukin 1 beta Rattus norvegicus 126-148 31298403-14 2019 Furthermore, the serum levels of TNF-alpha, IL-1beta, IL-6 and KC-GRO were significantly downregulated in the 22-oxacalcitriol group. maxacalcitol 110-126 interleukin 1 beta Rattus norvegicus 44-52 31185608-2 2019 Interleukin-1beta (IL-1beta) has been shown to induce the upregulation of MMP-9 through nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX)-reactive oxygen species (ROS)-dependent signaling pathways. Reactive Oxygen Species 154-177 interleukin 1 beta Rattus norvegicus 19-27 31185608-2 2019 Interleukin-1beta (IL-1beta) has been shown to induce the upregulation of MMP-9 through nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX)-reactive oxygen species (ROS)-dependent signaling pathways. Reactive Oxygen Species 179-182 interleukin 1 beta Rattus norvegicus 0-17 31185608-2 2019 Interleukin-1beta (IL-1beta) has been shown to induce the upregulation of MMP-9 through nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX)-reactive oxygen species (ROS)-dependent signaling pathways. Reactive Oxygen Species 179-182 interleukin 1 beta Rattus norvegicus 19-27 31185608-6 2019 The increased level of ROS generation in RBA-1 cells exposed to IL-1beta was attenuated by RTA 408, as determined by using 2",7"-dichlorodihydrofluorescein diacetate (DCFH-DA) and CellROX. Reactive Oxygen Species 23-26 interleukin 1 beta Rattus norvegicus 64-72 31185608-6 2019 The increased level of ROS generation in RBA-1 cells exposed to IL-1beta was attenuated by RTA 408, as determined by using 2",7"-dichlorodihydrofluorescein diacetate (DCFH-DA) and CellROX. 2',7'-dichlorodihydrofluorescein diacetate 123-165 interleukin 1 beta Rattus norvegicus 64-72 31185608-6 2019 The increased level of ROS generation in RBA-1 cells exposed to IL-1beta was attenuated by RTA 408, as determined by using 2",7"-dichlorodihydrofluorescein diacetate (DCFH-DA) and CellROX. diacetyldichlorofluorescein 167-174 interleukin 1 beta Rattus norvegicus 64-72 31185608-6 2019 The increased level of ROS generation in RBA-1 cells exposed to IL-1beta was attenuated by RTA 408, as determined by using 2",7"-dichlorodihydrofluorescein diacetate (DCFH-DA) and CellROX. cellrox 180-187 interleukin 1 beta Rattus norvegicus 64-72 31185608-7 2019 In addition, the inhibitory effects of RTA 408 on MMP-9 expression resulted from the suppression of the IL-1beta-stimulated activation of Pyk2 (proline-rich tyrosine kinase), platelet-derived growth factor receptor beta (PDGFRbeta), Akt, ROS, and mitogen-activated protein kinases (MAPKs). Reactive Oxygen Species 238-241 interleukin 1 beta Rattus norvegicus 104-112 30978553-5 2019 RESULTS: In both the periodontal ligament and pulp cells, the expression levels of IL-1B, TNFalpha, RANKL, and CSF1 were significantly higher in the CTF-treated group than in the control group. CHEMBL408967 149-152 interleukin 1 beta Rattus norvegicus 83-88 30978553-7 2019 High expression of IL-1B, TNFalpha, RANKL, and CSF1 at the root apex were also detected immunohistochemically in rats after tooth movement, but were decreased by acetaminophen administration. Acetaminophen 162-175 interleukin 1 beta Rattus norvegicus 19-24 30953818-11 2019 However, high-dose XZK was superior to lovastatin in the suppression of IL-1beta mRNA level and TNF-alpha protein level in hippocampal tissue after CPR. Lovastatin 39-49 interleukin 1 beta Rattus norvegicus 72-80 31056470-1 2019 PURPOSE: To investigate whether dexmedetomidine (Dex) can reduce the production of inflammatory factor IL-1beta by inhibiting the activation of NLRP3 inflammasome in hippocampal microglia, thereby alleviating the inflammatory response of the central nervous system induced by surgical injury. Dexmedetomidine 32-47 interleukin 1 beta Rattus norvegicus 103-111 31056470-1 2019 PURPOSE: To investigate whether dexmedetomidine (Dex) can reduce the production of inflammatory factor IL-1beta by inhibiting the activation of NLRP3 inflammasome in hippocampal microglia, thereby alleviating the inflammatory response of the central nervous system induced by surgical injury. Dexmedetomidine 49-52 interleukin 1 beta Rattus norvegicus 103-111 31056470-12 2019 CONCLUSION: Dex can inhibit the activation of microglia and NLRP3 inflammasome in the hippocampus of rats after operation, and the synthesis and secretion of IL-1beta are also reduced in a dose-dependent manner by using Dex. Dexmedetomidine 12-15 interleukin 1 beta Rattus norvegicus 158-166 31056470-12 2019 CONCLUSION: Dex can inhibit the activation of microglia and NLRP3 inflammasome in the hippocampus of rats after operation, and the synthesis and secretion of IL-1beta are also reduced in a dose-dependent manner by using Dex. Dexmedetomidine 220-223 interleukin 1 beta Rattus norvegicus 158-166 31150368-9 2019 RESULTS: Triptolide promoted locomotion recovery of SCI rats, upregulated the expression of miR-96, decreased microglia activation marker Iba-1 and IKKbeta/NF-kappaB-related proteins, and inhibited inflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta levels in spinal cord tissues and lipopolysaccharide -induced microglia. triptolide 9-19 interleukin 1 beta Rattus norvegicus 253-270 31185608-2 2019 Interleukin-1beta (IL-1beta) has been shown to induce the upregulation of MMP-9 through nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX)-reactive oxygen species (ROS)-dependent signaling pathways. NAD 88-121 interleukin 1 beta Rattus norvegicus 0-17 31185608-2 2019 Interleukin-1beta (IL-1beta) has been shown to induce the upregulation of MMP-9 through nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX)-reactive oxygen species (ROS)-dependent signaling pathways. NAD 88-121 interleukin 1 beta Rattus norvegicus 19-27 31185608-2 2019 Interleukin-1beta (IL-1beta) has been shown to induce the upregulation of MMP-9 through nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX)-reactive oxygen species (ROS)-dependent signaling pathways. Reactive Oxygen Species 154-177 interleukin 1 beta Rattus norvegicus 0-17 31281400-19 2019 The protective effect of special electromagnetic field treated water and far infrared rays on endotoxin-induced acute respiratory distress syndrome may result from their role in reducing the levels of IL-1beta and IL-6 in serum and the expression level of p65 protein in lung tissue, in addition to reliving inflammatory response, lung coefficient, and lungs edema. Water 63-68 interleukin 1 beta Rattus norvegicus 201-209 30607691-4 2019 RESULTS: The results indicated that 4-PBA attenuated the following: (1) pancreas and intestinal pathological injuries, (2) serum TNF-alpha, IL-1beta, and IL-6, (3) serum DAO level, serum endotoxin level, (4) the apoptosis of IECs, (5) ER stress markers (caspase-12, CHOP, GRP78, PERK, IRE1alpha, ATF6) and caspase-3 expression in intestinal. 4-phenylbutyric acid 36-41 interleukin 1 beta Rattus norvegicus 140-148 31210303-12 2019 Nevertheless, relative levels of classical inflammatory stimulators IL-1beta, TNF-alpha and IL-6 were downregulated accordingly by miR-137-5p overexpression. mir-137-5p 131-141 interleukin 1 beta Rattus norvegicus 68-76 30570747-8 2019 The microinjection of the P2X7R antagonist brilliant blue G (BBG, a non-competitive P2X7R antagonist) into the RVM prevented the development of mechanical allodynia, inhibited the activation of microglia, and decreased the expression of IL-1beta and 8-hydroxyguanine in the RVM following SMIR. coomassie Brilliant Blue 43-59 interleukin 1 beta Rattus norvegicus 237-245 30729381-0 2019 Baicalein Inhibits the IL-1beta-Induced Inflammatory Response in Nucleus Pulposus Cells and Attenuates Disc Degeneration In vivo. baicalein 0-9 interleukin 1 beta Rattus norvegicus 23-31 30729381-4 2019 In vitro, NP cells were pretreated with baicalein for 2 h and then incubated with IL-1beta for 24 h. We found that baicalein not only inhibited the overexpression of inflammatory cytokine production, including NO, PGE2, TNF-alpha, and IL-6, but also suppressed the expression of COX-2 and iNOS. baicalein 115-124 interleukin 1 beta Rattus norvegicus 82-90 30729381-5 2019 The IL-1beta-induced overexpression of MMP13 and ADAMTS5 and degradation of aggrecan and type II collagen were reversed by baicalein in a dose-dependent manner. baicalein 123-132 interleukin 1 beta Rattus norvegicus 4-12 30729381-6 2019 Mechanistically, we found that baicalein suppressed the IL-1beta-induced activation of the NF-kappaB and MAPK pathways. baicalein 31-40 interleukin 1 beta Rattus norvegicus 56-64 30811752-2 2019 Administration of DAS (50, 100, and 200 mg/kg) along with CCL 4 effectively mitigated serum aspartate aminotransferase, alanine aminotransferase activities, MDA, TNF-alpha, IL-1beta, and MCP-1 levels, as well as significantly restored HO-1, GSH levels and SOD activity in liver tissues compared with those in rats treated with CCL 4 . allyl sulfide 18-21 interleukin 1 beta Rattus norvegicus 173-181 31082734-9 2019 On treating the STZ injected diabetic rats with AuNPs, all the retinal mRNA expressions of VEGF-1, Tumor Necrosis Factor (TNFalpha), Monocyte Chemotactic Proteins-1 (MCP-1), Intercellular Adhesion Molecule-1 (ICAM-1), and Interleukin (IL)-6, IL-1beta were observed to be reduced. Streptozocin 16-19 interleukin 1 beta Rattus norvegicus 242-250 30848438-11 2019 miR-340-5p overexpression also decreased inflammation as well as expression levels of COX-2, IL-1beta, TNF-alpha and IL-6 in CCI rats. mir-340-5p 0-10 interleukin 1 beta Rattus norvegicus 93-101 30680694-8 2019 Furthermore, ZnPPIX, the HO-1 inhibitor, weakened honokiol-mediated morphological amelioration, and the reduced level of TNF-alpha, IL-1beta, and IL-6 in kidneys of rats subjected to CLP. zinc protoporphyrin 13-19 interleukin 1 beta Rattus norvegicus 132-140 31133150-13 2019 Parecoxib may achieve analgesic effects by down-regulating the expression of IL-1beta, IL-6 and TNF-alpha in the spinal cord. parecoxib 0-9 interleukin 1 beta Rattus norvegicus 77-85 30328550-9 2019 All these effects of extracellular cGMP are due to a reduction of hippocampal IL-1beta levels in hyperammonemic rats, which reduces IL-1 receptor-mediated Src over-activation. Cyclic GMP 35-39 interleukin 1 beta Rattus norvegicus 78-86 30570747-8 2019 The microinjection of the P2X7R antagonist brilliant blue G (BBG, a non-competitive P2X7R antagonist) into the RVM prevented the development of mechanical allodynia, inhibited the activation of microglia, and decreased the expression of IL-1beta and 8-hydroxyguanine in the RVM following SMIR. coomassie Brilliant Blue 61-64 interleukin 1 beta Rattus norvegicus 237-245 30350190-7 2019 Interleukin-1 beta transcript expression was significantly decreased with amitriptyline treatment at 6 h, although protein expression did not differ between groups. Amitriptyline 74-87 interleukin 1 beta Rattus norvegicus 0-18 30916854-11 2019 Compared with model group, TLR4 mRNA expression, the protein expression of TLR4 and MCT, and the number of mast cells with degranulation in the colonic tissue, serum concentration of IL-1beta and IL-8 were all significantly decreased in EA and MCS group. mcs 244-247 interleukin 1 beta Rattus norvegicus 183-191 30989724-10 2019 Further, treatment with PD168393 attenuated mechanical allodynia in CYP-induced cystitis and inhibited microglia activation, leading to decreased production of IL-1beta. PD168393 24-32 interleukin 1 beta Rattus norvegicus 160-168 31028905-8 2019 The results showed that CX-10 exerted potent anti-inflammatory and anti-oxidation activities, which significantly inhibited LPS-induced TNF-alpha and NO release, lowered TNF-alpha and IL-1beta levels in the brain, meanwhile increased activities of SOD, CAT and GSH-P x . cx-10 24-29 interleukin 1 beta Rattus norvegicus 184-192 30922766-13 2019 The CCI-induced increase in IL-6, IL-1beta, TNF-alpha, PI3K/Akt signaling and their phosphorylation was also suppressed by repeated post-CCI cryptotanshinone treatment. CCI 4-7 interleukin 1 beta Rattus norvegicus 34-42 31159189-7 2019 Release of TNF-alpha, IL-6, and IL-1beta after stimulation with palmitic, oleic, linoleic acid, or C6 ceramide in primary microglia culture were quantified using ELISA. oleic 74-79 interleukin 1 beta Rattus norvegicus 32-40 31159189-9 2019 Additionally, in contrast to oleic, linoleic, or C6 ceramide stimulation in primary microglia culture, stimulation with palmitic acid for 24 h promotes TNF-alpha, IL-6, and IL-1beta release and TBK1 activation. Palmitic Acid 120-133 interleukin 1 beta Rattus norvegicus 173-181 30890451-9 2019 The pharmacodynamic study showed that DMNs-NT significantly reduced the toe swelling of RA rats and reduced the levels of TNF-alpha and IL-1beta in serum to alleviate the injury of the ankle joints. dmns-nt 38-45 interleukin 1 beta Rattus norvegicus 136-144 31191315-5 2019 Furthermore, compared with BM-MSCs, PB-MSCs in a co-culture system with lipopolysaccharide-induced M1-type macrophages more efficiently promoted M1 polarization to M2, accompanied by increasing expression of CD206, Arg-1, IL-10, and CCL-22 while decreasing expression of M1 markers including iNOS, TNF-alpha, IL-1beta and IL-6, indicating that PB-MSCs triggered greater M1 polarization to M2. Lead 36-38 interleukin 1 beta Rattus norvegicus 309-317 30922766-13 2019 The CCI-induced increase in IL-6, IL-1beta, TNF-alpha, PI3K/Akt signaling and their phosphorylation was also suppressed by repeated post-CCI cryptotanshinone treatment. cryptotanshinone 141-157 interleukin 1 beta Rattus norvegicus 34-42 30779975-7 2019 Sleep deprivation enhanced the expression of hippocampal inflammatory factors IL-1beta and IL-6 after sevoflurane inhalation. Sevoflurane 102-113 interleukin 1 beta Rattus norvegicus 78-86 31125314-14 2019 At 50 and 100 mg/kg, the methanolic extract significantly (p<0.05 and p<0.01) decreased the Interleukin-1beta (IL-1beta) serum level, compared to negative control (Tween-DMSO 8%). methanolic 25-35 interleukin 1 beta Rattus norvegicus 98-115 31125314-14 2019 At 50 and 100 mg/kg, the methanolic extract significantly (p<0.05 and p<0.01) decreased the Interleukin-1beta (IL-1beta) serum level, compared to negative control (Tween-DMSO 8%). methanolic 25-35 interleukin 1 beta Rattus norvegicus 117-125 31164864-3 2019 Recent studies reported that high glucose stimulates the interaction of TxNIP with the inflammasome protein NLRP3 (NLR family, pyrin domain containing 3) to increase interleukin-1 beta (IL1beta) secretion by pancreatic beta cells. Glucose 34-41 interleukin 1 beta Rattus norvegicus 166-184 31164864-3 2019 Recent studies reported that high glucose stimulates the interaction of TxNIP with the inflammasome protein NLRP3 (NLR family, pyrin domain containing 3) to increase interleukin-1 beta (IL1beta) secretion by pancreatic beta cells. Glucose 34-41 interleukin 1 beta Rattus norvegicus 186-193 30776439-3 2019 By flow cytometry and ELISA analysis, sulfated polysaccharide SFMP-1 showed the best protective effect in reducing PM2.5-induced cell death, cell apoptosis and production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta), which was accompanied by a diminished level in reactive oxygen species (ROS) formation caused by PM2.5 in rat alveolar macrophage NR8383 cells. Polysaccharides 47-61 interleukin 1 beta Rattus norvegicus 218-236 30776439-3 2019 By flow cytometry and ELISA analysis, sulfated polysaccharide SFMP-1 showed the best protective effect in reducing PM2.5-induced cell death, cell apoptosis and production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta), which was accompanied by a diminished level in reactive oxygen species (ROS) formation caused by PM2.5 in rat alveolar macrophage NR8383 cells. Polysaccharides 47-61 interleukin 1 beta Rattus norvegicus 238-246 30776439-3 2019 By flow cytometry and ELISA analysis, sulfated polysaccharide SFMP-1 showed the best protective effect in reducing PM2.5-induced cell death, cell apoptosis and production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta), which was accompanied by a diminished level in reactive oxygen species (ROS) formation caused by PM2.5 in rat alveolar macrophage NR8383 cells. sfmp-1 62-68 interleukin 1 beta Rattus norvegicus 218-236 30776439-3 2019 By flow cytometry and ELISA analysis, sulfated polysaccharide SFMP-1 showed the best protective effect in reducing PM2.5-induced cell death, cell apoptosis and production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta), which was accompanied by a diminished level in reactive oxygen species (ROS) formation caused by PM2.5 in rat alveolar macrophage NR8383 cells. sfmp-1 62-68 interleukin 1 beta Rattus norvegicus 238-246 31139184-0 2019 Cannabinoid Receptor 2 Agonist JWH-015 Inhibits Interleukin-1beta-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts and in Adjuvant Induced Arthritis Rat via Glucocorticoid Receptor. JHW 015 31-38 interleukin 1 beta Rattus norvegicus 48-65 31193169-10 2019 ELISA results showed that ASA VI blocked the release of TNF-alpha, IL-6 and IL-1beta in ADSCs. Aspirin 26-29 interleukin 1 beta Rattus norvegicus 76-84 30606939-7 2019 In addition, retinal expression levels of NLRP3, cleaved caspase-1 p20, IL-1beta p17, and ASC were dramatically increased in STZ-induced DR, and this was abolished by SFN intervention. Streptozocin 125-128 interleukin 1 beta Rattus norvegicus 72-80 30606939-7 2019 In addition, retinal expression levels of NLRP3, cleaved caspase-1 p20, IL-1beta p17, and ASC were dramatically increased in STZ-induced DR, and this was abolished by SFN intervention. sulforaphane 167-170 interleukin 1 beta Rattus norvegicus 72-80 31065039-6 2019 Exposure to sodium nitrite (SN) resulted in increased levels of malondialdehyde, TGF-beta, c-reactive protein, NF-kappaB, TNF-alpha, IL-1beta and caspase-3 associated with reduced levels of glutathione, cytochrome c oxidase, Nrf2 and IL-10. Sodium Nitrite 12-26 interleukin 1 beta Rattus norvegicus 133-141 31065039-6 2019 Exposure to sodium nitrite (SN) resulted in increased levels of malondialdehyde, TGF-beta, c-reactive protein, NF-kappaB, TNF-alpha, IL-1beta and caspase-3 associated with reduced levels of glutathione, cytochrome c oxidase, Nrf2 and IL-10. Sodium Nitrite 28-30 interleukin 1 beta Rattus norvegicus 133-141 29482373-6 2019 Inflammatory markers (IL-1beta, IL-6 & TNF-alpha) levels were significantly reduced after the administration of TQ alone and TQ + fluoxetine. tq + fluoxetine 129-144 interleukin 1 beta Rattus norvegicus 22-30 29482373-6 2019 Inflammatory markers (IL-1beta, IL-6 & TNF-alpha) levels were significantly reduced after the administration of TQ alone and TQ + fluoxetine. thymoquinone 116-118 interleukin 1 beta Rattus norvegicus 22-30 30893507-9 2019 Cisplatin upregulates cytokines (i.e., TNF-alpha and IL-1beta) and NF-kappaB, and downregulates Nrf2 and HO-1. Cisplatin 0-9 interleukin 1 beta Rattus norvegicus 53-61 30802833-7 2019 BDE-209 and DBDPE-induced inflammation was characterized by the upregulation of key inflammatory mediators, including interleukin-1beta (IL-1beta), IL-6, IL-10, and tumor necrosis factor alpha (TNFalpha). decabromodiphenyl ethane 12-17 interleukin 1 beta Rattus norvegicus 118-135 30648297-9 2019 IL-1beta exposure-induced beta-cell stress after 4 H, decreased insulin levels, and increased thioflavin binding were noted. thioflavin T 94-104 interleukin 1 beta Rattus norvegicus 0-8 30802833-7 2019 BDE-209 and DBDPE-induced inflammation was characterized by the upregulation of key inflammatory mediators, including interleukin-1beta (IL-1beta), IL-6, IL-10, and tumor necrosis factor alpha (TNFalpha). decabromodiphenyl ethane 12-17 interleukin 1 beta Rattus norvegicus 137-145 30988709-6 2019 In addition, beta-PAE significantly inhibited the release of proinflammatory factors, including tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6. beta-patchoulene 13-21 interleukin 1 beta Rattus norvegicus 125-147 30911963-7 2019 In addition, biotin decreased the pro-inflammatory cytokines (interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrotic factor alpha (TNF-alpha)), caspase-3, poly(ADP-ribose) polymerase 1 (PARP1) level, and PARP1 gene expression. Biotin 13-19 interleukin 1 beta Rattus norvegicus 62-80 30911963-7 2019 In addition, biotin decreased the pro-inflammatory cytokines (interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrotic factor alpha (TNF-alpha)), caspase-3, poly(ADP-ribose) polymerase 1 (PARP1) level, and PARP1 gene expression. Biotin 13-19 interleukin 1 beta Rattus norvegicus 82-90 30785088-3 2019 SCI models were established using the weight-drop method in rats, additionally, single polydatin administration (20, 40 mg/kg body weight) remarkably improved motor function of SCI rat, along with decreased nitric oxide (NO) generation and inflammatory factor (IL-1beta, IL-6 and TNF-alpha) production in spinal cord tissues. polydatin 87-96 interleukin 1 beta Rattus norvegicus 261-269 30580614-10 2019 Paeonol also reduced NF-kappaB, IL-1beta, and caspase 3 gene expressions. paeonol 0-7 interleukin 1 beta Rattus norvegicus 32-40 30836069-11 2019 DOX also triggered activation of nuclear factor kappa B (NF-kappaB) and increased the levels of pro-inflammatory cytokines (TNF-alpha, IL-6, and IL-1beta) and expression of the inflammatory mediators (iNOS and COX-2) in the heart. Doxorubicin 0-3 interleukin 1 beta Rattus norvegicus 145-153 31182933-10 2019 SHINBARO2 also suppressed the expression of proinflammatory cytokines including tumor necrosis factor-alpha and interleukin-1beta. shinbaro2 0-9 interleukin 1 beta Rattus norvegicus 112-129 30688278-9 2019 Our data revealed that (5R)-5-hydroxytriptolide inhibited the generation of nitric oxide, tumor necrosis factor-alpha and interleukin-1beta from primary astrocytes activated by lipopolysaccharide, decreased the positive reaction intensity of glial fibrillary acidic protein, reduced the expression of tumor necrosis factor alpha and interleukin-1beta in culture supernatant, inhibited the phosphorylation of IkappaB-alpha and the translocation of nuclear factor-kappaB/P65 to the nucleus. 5alpha-Hydroxytriptolide 23-47 interleukin 1 beta Rattus norvegicus 122-139 30688278-9 2019 Our data revealed that (5R)-5-hydroxytriptolide inhibited the generation of nitric oxide, tumor necrosis factor-alpha and interleukin-1beta from primary astrocytes activated by lipopolysaccharide, decreased the positive reaction intensity of glial fibrillary acidic protein, reduced the expression of tumor necrosis factor alpha and interleukin-1beta in culture supernatant, inhibited the phosphorylation of IkappaB-alpha and the translocation of nuclear factor-kappaB/P65 to the nucleus. 5alpha-Hydroxytriptolide 23-47 interleukin 1 beta Rattus norvegicus 333-350 30742852-9 2019 Also chronic administration of methamphetamine could increase malondialdehyde (MDA), tumor necrosis factor-Alpha (TNF-alpha) and interleukine-1 beta (IL-1beta) in rats, while caused reduction of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) activities. Methamphetamine 31-46 interleukin 1 beta Rattus norvegicus 150-158 30852743-6 2019 It was found that the level of MEK phosphorylation was upregulated after LPS stimulation, which was blocked by 10 mug/ml of papaverine.10muM U0126 significantly inhibited TNF-alpha and IL-1beta and increased IL-10 transcription and expression in retinal microglia (P < 0.01). Papaverine 124-134 interleukin 1 beta Rattus norvegicus 185-193 30852743-6 2019 It was found that the level of MEK phosphorylation was upregulated after LPS stimulation, which was blocked by 10 mug/ml of papaverine.10muM U0126 significantly inhibited TNF-alpha and IL-1beta and increased IL-10 transcription and expression in retinal microglia (P < 0.01). U 0126 141-146 interleukin 1 beta Rattus norvegicus 185-193 30848526-5 2019 Our results further demonstrated that baicalin administration negatively regulated the expression of interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF-alpha) in the hippocampus and hypothalamus. baicalin 38-46 interleukin 1 beta Rattus norvegicus 101-123 30975164-13 2019 Injured animals treated with JC124 also had significantly reduced protein expression levels of NLRP3, ASC, IL-1 beta, TNFalpha, iNOS, and caspase-1. JC124 29-34 interleukin 1 beta Rattus norvegicus 107-116 31060166-15 2019 In addition, the concentrations of IL-1beta and IL-6 decreased [(21.79+-3.95) pg/ml vs (31.78+-4.12) pg/ml, (34.68+-4.28) pg/ml vs (49.15+-3.47) pg/ml, both P<0.01] and the expressions of RAGE, p-P38, nuclear NF-kappaB, cleaved caspase-3 up-regulated in the bamboo leaf flavonoid group. Flavonoids 273-282 interleukin 1 beta Rattus norvegicus 35-43 30981278-12 2019 MIF-induced production of PGE2 from astrocytes was able to suppress production of TNF-alpha, but boosted production of IL-1beta and IL-6 in LPS-activated macrophages. Dinoprostone 26-30 interleukin 1 beta Rattus norvegicus 119-127 30975172-11 2019 Paeoniflorin reduced the response of astrocytes and microglia to injury, decreased the expression of IL-1beta and TNF-alpha, and downregulated the expression of CGRP induced by CCI. peoniflorin 0-12 interleukin 1 beta Rattus norvegicus 101-109 30667526-13 2019 Rats with a history of adolescent EtOH displayed a severely blunted neuroimmune response in adulthood, evinced by suppressed IL-1beta, IL-10, and TNF-alpha. Ethanol 34-38 interleukin 1 beta Rattus norvegicus 125-133 31043768-8 2019 Moreover, CDDP enhanced the synthesis of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6. Cisplatin 10-14 interleukin 1 beta Rattus norvegicus 105-122 30711241-13 2019 The level of IL-1beta was highest in the DM group, and decreased significantly in the mirtazapine-treated group. dm 41-43 interleukin 1 beta Rattus norvegicus 13-21 30711241-13 2019 The level of IL-1beta was highest in the DM group, and decreased significantly in the mirtazapine-treated group. Mirtazapine 86-97 interleukin 1 beta Rattus norvegicus 13-21 30274910-9 2019 Furthermore, simvastatin pretreatment affected superoxide dismutase and malondialdehyde activities (P < 0.05) to reduce oxidative stress, and inhibited levels of high-mobility group box-1, CD68, toll-like receptor 4, tumor necrosis factor alpha, interleukin-1beta and interleukin-6 (P < 0.05) to suppress inflammatory response. Simvastatin 13-24 interleukin 1 beta Rattus norvegicus 246-263 30711241-14 2019 CONCLUSION: In this study, 20 mg/kg/day mirtazapine administration for 2 weeks reduced NLRP3 and caspase-1 expressions and IL-1beta level in the diabetic rat kidneys. Mirtazapine 40-51 interleukin 1 beta Rattus norvegicus 123-131 30936996-7 2019 Cerebral ischemia increased the expression levels of TLR4, NF-kappaB p65, COX-2, MMP-9, TNF-alpha and IL-1beta, but all of these factors were reduced by resveratrol. Resveratrol 153-164 interleukin 1 beta Rattus norvegicus 102-110 30072162-5 2019 RESULTS: Serum levels of TNF-alpha, IL-4, IL-6 and IL-1beta were significantly decreased in the hesperidin- and antibiotic-treated groups compared to the AOM group. Hesperidin 96-106 interleukin 1 beta Rattus norvegicus 51-59 30771585-5 2019 Specifically, MSC exosomes enhanced s-GAG synthesis impeded by IL-1beta, and suppressed IL-1beta-induced nitric oxide and MMP13 production. Nitric Oxide 105-117 interleukin 1 beta Rattus norvegicus 88-96 30713033-10 2019 RESULTS: In rats pre-treated with FK506, the levels of transaminases, TNF-alpha and IL-1beta were reduced significantly and also liver damage was dramatically mitigated compared to those without FK506 pre-treatment. Tacrolimus 34-39 interleukin 1 beta Rattus norvegicus 84-92 30315524-7 2019 These results demonstrated that SW significantly inhibited IL-1beta-induced NO and PGE2 production, as well as MMP-1, MMP3, MMP13, and ADAMTS-5 mRNA expression. Dinoprostone 83-87 interleukin 1 beta Rattus norvegicus 59-67 30785069-0 2019 Ligustilide alleviated IL-1beta induced apoptosis and extracellular matrix degradation of nucleus pulposus cells and attenuates intervertebral disc degeneration in vivo. ligustilide 0-11 interleukin 1 beta Rattus norvegicus 23-31 30503749-5 2019 In an in vivo study, resveratrol significantly recovered the insulin level and PON1 expression and activity, as well as clearly reduced the retinal vascular permeability, retinal AGEs, LDL, Ox-LDL, caspase3 activity, retinal damage, IL-1beta, IL-6, TNFalpha, VEGF, IFNgamma and MCP-1 in STZ-diabetic rats. Resveratrol 21-32 interleukin 1 beta Rattus norvegicus 233-241 29907915-9 2019 Guanosine treatment also lowered interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha mRNA levels. Guanosine 0-9 interleukin 1 beta Rattus norvegicus 33-50 31531058-8 2019 In addition, METH treatment increased lipid peroxidation and the levels of oxidized form of glutathione (GSSG), interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and Bax, while reducing reduced form of glutathione (GSH), Bcl-2, P-CREB, and BDNF levels in the hippocampus. Methamphetamine 13-17 interleukin 1 beta Rattus norvegicus 112-130 31531058-8 2019 In addition, METH treatment increased lipid peroxidation and the levels of oxidized form of glutathione (GSSG), interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and Bax, while reducing reduced form of glutathione (GSH), Bcl-2, P-CREB, and BDNF levels in the hippocampus. Methamphetamine 13-17 interleukin 1 beta Rattus norvegicus 132-140 30785069-6 2019 In this study, we found that ligustilide inhibited apoptosis, suppressed the expression of related inflammatory mediators (iNOS and COX-2) and decreased the expression of inflammatory cytokines (TNF-a and IL-6) in nucleus pulposus cells under IL-1beta stimulation. ligustilide 29-40 interleukin 1 beta Rattus norvegicus 243-251 30600184-11 2019 Overexpression of miR-24 significantly reduced LPS-induced lung damage and decreased the release of proinflammatory cytokine TNF-alpha, IL-6, IL-1beta and SP-A, SP-D expression induced by LPS. mir-24 18-24 interleukin 1 beta Rattus norvegicus 142-150 30585984-6 2019 Intravenous injection of clodronate liposomes depleted synovial macrophages, which decreased the level of not only proinflammatory mediator interleukin-1beta but also NGF in the knee joint, leading to pain suppression in the advanced OA model. Clodronic Acid 25-35 interleukin 1 beta Rattus norvegicus 140-157 30813721-8 2019 Anthocyanins suppressed microgliosis and astrocytosis and reduced the overexpression of nuclear factor kappa B (NF-kappaB), interleukin-1-beta (IL-1beta), cyclooxygenase-2 (COX-2), and tumor necrosis factor-alpha (TNF-alpha). Anthocyanins 0-12 interleukin 1 beta Rattus norvegicus 124-142 30653286-8 2019 ALTB also increased interleukin-1beta levels in the striatum and frontal cortex and tumoral necrosis factor-alpha levels in the frontal cortex compared with those of AL, TB, and CT rats. Alcohols 0-2 interleukin 1 beta Rattus norvegicus 20-37 30813721-8 2019 Anthocyanins suppressed microgliosis and astrocytosis and reduced the overexpression of nuclear factor kappa B (NF-kappaB), interleukin-1-beta (IL-1beta), cyclooxygenase-2 (COX-2), and tumor necrosis factor-alpha (TNF-alpha). Anthocyanins 0-12 interleukin 1 beta Rattus norvegicus 144-152 30967905-11 2019 Glutamine mitigated this tissue damage, with visible regeneration of hepatic parenchyma; decreased TBARS (P < 0.001), GSH (P < 0.01), IL-1beta, IL6, and TNFalpha levels (P <0.01) in hepatic tissue; and decreased blood levels of AST, ALT, and ALP (P <0.05). Glutamine 0-9 interleukin 1 beta Rattus norvegicus 140-148 31011359-4 2019 The plasma biochemical indexes showed that therapeutic dose of lipid-soluble alkaloids of FZ could significantly inhibit the concentrations of IL-1beta, TNF-alpha, and IFN-gamma in AIA rats, and combination with total glucosides of peony could further reduce the concentration of IL-1beta. Alkaloids 77-86 interleukin 1 beta Rattus norvegicus 143-151 31011359-4 2019 The plasma biochemical indexes showed that therapeutic dose of lipid-soluble alkaloids of FZ could significantly inhibit the concentrations of IL-1beta, TNF-alpha, and IFN-gamma in AIA rats, and combination with total glucosides of peony could further reduce the concentration of IL-1beta. Alkaloids 77-86 interleukin 1 beta Rattus norvegicus 280-288 31015796-5 2019 In in vitro neurons, G3335 (PPAR-gamma antagonist) reversed the rosiglitazone-induced inhibition of caspase-1, interleukin 1 (IL-1beta), and interleukin 6 (IL-6). H-Trp-Glu-OH 21-26 interleukin 1 beta Rattus norvegicus 126-134 31015796-5 2019 In in vitro neurons, G3335 (PPAR-gamma antagonist) reversed the rosiglitazone-induced inhibition of caspase-1, interleukin 1 (IL-1beta), and interleukin 6 (IL-6). Rosiglitazone 64-77 interleukin 1 beta Rattus norvegicus 126-134 31015796-6 2019 Rosiglitazone inhibited the expression of NLRP3, caspase-1, IL-1beta, and IL-6. Rosiglitazone 0-13 interleukin 1 beta Rattus norvegicus 60-68 30836963-12 2019 The levels of proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in the offspring of the Poly I:C-exposed mothers differed with brain region and time, with more cytokines elevated during periadolescence than during adulthood. Poly I-C 96-104 interleukin 1 beta Rattus norvegicus 41-49 30984340-6 2019 The production of free radicals evidenced as dichlorodihydrofluorescein assay and the activity of NADPH oxidase and xanthine oxidase and IL-1beta concentration were significantly higher in the parotid and submandibular glands of AP rats compared to the controls. Free Radicals 18-31 interleukin 1 beta Rattus norvegicus 137-145 30590313-4 2019 JBP485 treatment ameliorated indomethacin-induced enteropathy characterized by severe histopathological changes and a large number of TUNEL-positive cells in rat intestinal epithelium, elevated levels of MDA, MPO, TNF-alpha, IL-6, IL-1beta and increased expression of COX-2, and reduced levels of SOD, GSH, CAT, HDL-c, PGE2, expression of COX-1 and Bcl-2/Bax ratio in rat intestinal tissues. Indomethacin 29-41 interleukin 1 beta Rattus norvegicus 231-239 30616083-11 2019 With regard to anti-inflammatory mechanisms, zeaxanthin suppressed tumor necrosis factor-alpha, interferon-gamma, interleukin-6, interleukin-1 beta, and nuclear transcription factor kappa B levels, and inhibited nitric oxide synthase and cyclooxygenase-2 protein expression. Zeaxanthins 45-55 interleukin 1 beta Rattus norvegicus 129-147 30941189-7 2019 LPS-resulting increase of TNFalpha and IL-1beta in both serum and kidney of rats and NRK-52E cells was inhibited by EVO. evodiamine 116-119 interleukin 1 beta Rattus norvegicus 39-47 30941189-9 2019 EVO-induced reduction of TNFalpha and IL-1beta expression in LPS-treated cells was blocked by overexpression of P65 NF-kappaB. evodiamine 0-3 interleukin 1 beta Rattus norvegicus 38-46 30936601-11 2019 The chronic abuse of methamphetamine increased malondialdehyde, tumor necrosis factor-alpha, and interleukin-1beta, while it decreased superoxide dismutase, glutathione peroxidase, and glutathione reductase activities. Methamphetamine 21-36 interleukin 1 beta Rattus norvegicus 97-114 30442066-9 2019 The in vivo studies in rat ear model displayed a ~2 fold reduction in comedones count and cytokines (TNF-alpha and IL-1beta) on co-application with curcumin and lauric acid liposomal gel compared to placebo treated group. Curcumin 148-156 interleukin 1 beta Rattus norvegicus 115-123 30442066-9 2019 The in vivo studies in rat ear model displayed a ~2 fold reduction in comedones count and cytokines (TNF-alpha and IL-1beta) on co-application with curcumin and lauric acid liposomal gel compared to placebo treated group. lauric acid 161-172 interleukin 1 beta Rattus norvegicus 115-123 30664158-8 2019 Additionally, curculigoside decreased serum levels of TNF-alpha, IL-1beta, IL-6, IL-10, IL-12 and IL-17A in CIA rats. curculigoside 14-27 interleukin 1 beta Rattus norvegicus 65-73 30569099-9 2019 Kaempferol significantly reduced the overproduction of TNF-alpha, IL-1beta, interleukin-6, ICAM-1 and VCAM-1 induced by LPS, indicating the negative regulation of kaempferol in TLR4, NF-kappaB and STAT signaling underlying intestinal inflammation. kaempferol 0-10 interleukin 1 beta Rattus norvegicus 66-74 29923060-6 2019 RESULTS: After 2 weeks, bleomycin significantly increased the pressure at the airway opening (PAO), a functional parameter related to fibrosis-induced lung stiffness, and induced diffuse lung interstitium fibrosis, with upregulation of inflammation (IL1beta, MCP1) and tissue remodeling (COL1A1, COL3A1, ET1, MMP7, PDGFa, alphaSMA, SNAI1) markers. Bleomycin 24-33 interleukin 1 beta Rattus norvegicus 250-257 30589944-3 2019 Using western blot and qPCR, we found that both lipopolysaccharide and a combination of tumor necrosis factor-alpha and interleukin 1-beta decreased the expression levels of alpha-synuclein in primary culture of rat ENS, an effect that was prevented in the presence of the p38 inhibitors SB203580 and BIRB 796. SB 203580 288-296 interleukin 1 beta Rattus norvegicus 120-138 30589944-3 2019 Using western blot and qPCR, we found that both lipopolysaccharide and a combination of tumor necrosis factor-alpha and interleukin 1-beta decreased the expression levels of alpha-synuclein in primary culture of rat ENS, an effect that was prevented in the presence of the p38 inhibitors SB203580 and BIRB 796. doramapimod 301-309 interleukin 1 beta Rattus norvegicus 120-138 30622226-9 2019 The elevation in the levels of pronociceptive interleukins (IL-1beta, IL-18, MMP-9) after spinal cord injury was mitigated by dehydrocorybulbine. dehydrocorybulbine 126-144 interleukin 1 beta Rattus norvegicus 60-68 30462329-9 2019 Treatment with Fasudil decreased the expression of proinflammatory factors, including tumor necrosis factor-alpha, inducible nitric oxide synthase, interleukin-1beta, and interleukin-6; furthermore, it inactivated the nuclear factor kappa-light-chain-enhancer of activated B cells pathway. fasudil 15-22 interleukin 1 beta Rattus norvegicus 148-165 30480462-7 2019 Moreover, testicular TNF-alpha, IL-1beta, and iNOS and plasma IL-1beta levels were significantly increased in rats fed with fructose. Fructose 124-132 interleukin 1 beta Rattus norvegicus 32-40 30480462-7 2019 Moreover, testicular TNF-alpha, IL-1beta, and iNOS and plasma IL-1beta levels were significantly increased in rats fed with fructose. Fructose 124-132 interleukin 1 beta Rattus norvegicus 62-70 30369549-7 2019 ELISA results indicated that linagliptin significantly reduced overproduction of cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 post balloon injury. Linagliptin 29-40 interleukin 1 beta Rattus norvegicus 142-159 30369549-7 2019 ELISA results indicated that linagliptin significantly reduced overproduction of cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 post balloon injury. Linagliptin 29-40 interleukin 1 beta Rattus norvegicus 161-169 30791908-11 2019 Mechanistically, bexarotene increased the levels of PPARgamma and SIRT6; decreased the expression of phosphorylated FoxO3a (p-FoxO3a), IL-6, IL-1beta, and TNF-a; and inhibited the microglia activation and neutrophils infiltration at 24 h after SAH. Bexarotene 17-27 interleukin 1 beta Rattus norvegicus 141-149 30858801-9 2019 Treatment with bicuculline reduces astrocyte activation and IL-1beta but not microglia activation in the hippocampus of hyperammonemic rats. Bicuculline 15-26 interleukin 1 beta Rattus norvegicus 60-68 30810635-9 2019 Treatment with 1 mg/kg gliclazide reduced myeloperoxidase activity, malondialdehyde, IL-1beta, and TNF-alpha levels (p<=0.05), and resulted in weak staining for COX-2, cathepsin k, MMP-2, RANK, RANKL, SOD-1, GPx-1,MIF and PI3k. Gliclazide 23-33 interleukin 1 beta Rattus norvegicus 85-93 30792526-7 2019 Moreover, afatinib attenuated OGD-induced caspase 1 activation (a biomarker of inflammasome activation) and interleukin-1beta levels (a pro-inflammatory cytokine). Afatinib 10-18 interleukin 1 beta Rattus norvegicus 108-125 30891260-5 2019 The results indicated that baicalin has a protective effect on AR rats by inhibiting the release of immunoglobulin E (IgE), histamine, interleukin-1 beta (IL-1beta), interleukin-4 (IL-4), interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-alpha). baicalin 27-35 interleukin 1 beta Rattus norvegicus 135-153 30891260-5 2019 The results indicated that baicalin has a protective effect on AR rats by inhibiting the release of immunoglobulin E (IgE), histamine, interleukin-1 beta (IL-1beta), interleukin-4 (IL-4), interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-alpha). baicalin 27-35 interleukin 1 beta Rattus norvegicus 155-163 30736422-11 2019 Minocycline reversed CGRP-induced thermal nociception, glial activity, and down-regulated IL-1beta and IL-6 cytokines significantly at 6 h (t-test, p < 0.05). Minocycline 0-11 interleukin 1 beta Rattus norvegicus 90-98 30094758-11 2019 Compared with APIP group, the intervention of SB203580 alleviated the pathological injury of the pancreas and lungs, decreased serum AMY and LIPA, attenuated the secretion of TNF-alpha, IL-1beta, and IL-6 in lung, reduced the inflammatory cells" infiltration and lung W/D ratio and inhibited the activation of P38MAPK signaling pathway. SB 203580 46-54 interleukin 1 beta Rattus norvegicus 186-194 30604648-6 2019 Furthermore, cisplatin treated animals exhibited a noticeable pro-inflammatory response with the substantial increase in renal levels of TNF-alpha, IL-1beta, and IL-6 and decrease in the renal level of IL-10. Cisplatin 13-22 interleukin 1 beta Rattus norvegicus 148-156 30551030-6 2019 Additionally, the curcumin could effectively decrease mRNA expression of proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and suppress NF-kappaB activation. Curcumin 18-26 interleukin 1 beta Rattus norvegicus 100-108 30551030-7 2019 Curcumin also inhibited the stressed-induced P2X7R/NLRP3 inflammasome axis activation, along with the reduced transformation of pro-IL-1beta to mature IL-1beta. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 132-140 30551030-7 2019 Curcumin also inhibited the stressed-induced P2X7R/NLRP3 inflammasome axis activation, along with the reduced transformation of pro-IL-1beta to mature IL-1beta. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 151-159 30362071-13 2019 Up-regulated cardiac caspase-3, COX-II, cTn-I, iNOs, TNF-alpha, and IL-1beta mRNA, as well as protein expressions were significantly decreased (p < 0.05) by fisetin treatment. fisetin 160-167 interleukin 1 beta Rattus norvegicus 68-76 30328008-5 2019 The high-salt diet also resulted in higher levels of the PICs interleukin-6, interleukin-1beta, tumor necrosis factor alpha, and monocyte chemotactic protein-1, as well as higher gp91phox expression and superoxide production in the PVN. Salts 9-13 interleukin 1 beta Rattus norvegicus 77-94 30858867-11 2019 Pretreatment with TMP significantly reduced the levels of pro-inflammatory cytokines, including IL-1beta, IL-6 and TNF-alpha. tetramethylpyrazine 18-21 interleukin 1 beta Rattus norvegicus 96-104 30528878-1 2019 Synergistic expression of cyclooxygenase-2 (COX-2) by interleukin-1beta (IL-1beta) and bradykinin (BK) in peri-sensory neurons results in the production of prostanoids, which affects sensory neuronal activity and responsiveness and causes hyperalgesia. Prostaglandins 156-167 interleukin 1 beta Rattus norvegicus 54-71 30528878-1 2019 Synergistic expression of cyclooxygenase-2 (COX-2) by interleukin-1beta (IL-1beta) and bradykinin (BK) in peri-sensory neurons results in the production of prostanoids, which affects sensory neuronal activity and responsiveness and causes hyperalgesia. Prostaglandins 156-167 interleukin 1 beta Rattus norvegicus 73-81 30787593-8 2019 Additionally, ketamine significantly (P<0.005) suppressed IL-1beta, TNF-alpha, IL-6, caspase-6 and p21WAF1/CIP1, p53 expression and up-regulated the PI3K/AKT/GSK-3beta expression in the group of iso-induced rats. Ketamine 14-22 interleukin 1 beta Rattus norvegicus 61-69 30600100-5 2019 In neuroantigen-stimulated dLN cells of both sexes propranolol increased IL-1beta and IL-23/p19 expression and IL-17+ CD4+ cell frequency, but enhanced IL-17 production only in male rat CD4+ lymphocytes, thereby abrogating sexual dimorphism in IL-17 concentration observed in propranolol-free cultures. Propranolol 51-62 interleukin 1 beta Rattus norvegicus 73-81 30269239-0 2019 Correction to: Geniposide Suppresses Interleukin-1beta-Induced Inflammation and Apoptosis in Rat Chondrocytes via the PI3K/Akt/NF-kappaB Signaling Pathway. geniposide 15-25 interleukin 1 beta Rattus norvegicus 37-54 30483733-0 2019 Hyaluronic acid-chitosan nanoparticles encoding CrmA attenuate interleukin-1beta induced inflammation in synoviocytes in vitro. Hyaluronic Acid 0-15 interleukin 1 beta Rattus norvegicus 63-80 30834084-7 2019 Tangeretin further alleviated inflammation evoked by cisplatin as indicated by reduced NF-kappaB p65 subunit phosphorylation with a simultaneous decrement in its downstream effectors IL-1beta and TNF-alpha expression and protein levels. tangeretin 0-10 interleukin 1 beta Rattus norvegicus 183-191 30349936-10 2019 Moreover, it can be hypothesized that CINC-1 is placed upstream TNF-alpha, IL-1beta, and IL-6 among the prostaglandin-dependent fever-mediator cascade and amidst the prostaglandin-independent synthesis pathway of fever. Prostaglandins 104-117 interleukin 1 beta Rattus norvegicus 75-83 30366345-0 2019 Imipramine treatment reverses depressive- and anxiety-like behaviors, normalize adrenocorticotropic hormone, and reduces interleukin-1beta in the brain of rats subjected to experimental periapical lesion. Imipramine 0-10 interleukin 1 beta Rattus norvegicus 121-138 30366345-13 2019 However, rats treated with imipramine had lower IL-1beta and ACTH levels. Imipramine 27-37 interleukin 1 beta Rattus norvegicus 48-56 30668410-10 2019 Limonene displayed anti-inflammatory activity through decreasing the levels of TNF-a, IL-6, and IL-1beta and increasing the level of IL-10. Limonene 0-8 interleukin 1 beta Rattus norvegicus 96-104 30668410-11 2019 Limonene could down-regulate the expression of Nf-kappab, Il-1beta, and Mpo and up-regulate the expression of Gpx. Limonene 0-8 interleukin 1 beta Rattus norvegicus 58-66 30374891-12 2019 RESULTS: The results show that rats were subjected to CUMS procedure exhibited depressive-like behavior, increased TNF-alpha, IL-6, and IL-1beta levels in hippocampus and PFC, alteration of Bax and Bcl-2 mRNA levels in hippocampus, decreased p-Akt/Akt and p-GSK3beta/GSK3beta protein expression in hippocampus, and an increased apoptotic cell percentage in the hippocampal CA1 region. cums 54-58 interleukin 1 beta Rattus norvegicus 136-144 30374891-15 2019 When rats were injected with LY294002 before resveratrol treatment, the antidepressant effect of resveratrol was significantly attenuated, TNF-alpha, IL-6 and IL-1beta levels in hippocampus and PFC increased again, Bax mRNA levels increased and Bcl-2 mRNA levels decreased in hippocampus, and Akt/GSK3beta protein expression in hippocampus decreased. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 interleukin 1 beta Rattus norvegicus 159-167 30312741-12 2019 DS also decreased the concentrations of interleukin (IL)-1beta and IL-18, indicating anti-inflammation activity. Deuterium 0-2 interleukin 1 beta Rattus norvegicus 40-62 30691440-4 2019 RSV inhibited LPS-induced inflammatory injury in PC-12 cells via increasing viability, decreasing apoptosis, and suppressing IL-1beta, IL-6, and TNF-alpha expression. Resveratrol 0-3 interleukin 1 beta Rattus norvegicus 125-133 30395883-8 2019 These results showed that celastrol significantly suppressed HMGB1, NF-kappaB and IL-1beta mRNA and protein expression in DRG and alleviated CFA-evoked thermal hyperalgesia. celastrol 26-35 interleukin 1 beta Rattus norvegicus 82-90 30691208-8 2019 The expressions of IL-1beta and the percentage of apoptotic cells were higher in the CIN group than in the control and RSV groups, but they were lower in the RCIN group than in the CIN group. Respiratory Syncytial Virus Vaccines 119-122 interleukin 1 beta Rattus norvegicus 19-27 30761007-0 2019 Schisandrin A Inhibits the IL-1beta-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-kappaB Signal Pathways in Rat Chondrocytes. schizandrin A 0-13 interleukin 1 beta Rattus norvegicus 27-35 30761007-11 2019 Our results revealed that Schisandrin A could suppress the IL-1beta-induced production of NO and PGE2 in rat chondrocytes. schizandrin A 26-39 interleukin 1 beta Rattus norvegicus 59-67 30761007-11 2019 Our results revealed that Schisandrin A could suppress the IL-1beta-induced production of NO and PGE2 in rat chondrocytes. Dinoprostone 97-101 interleukin 1 beta Rattus norvegicus 59-67 30761007-13 2019 Additionally, Schisandrin A could inhibit IL-1beta-induced cartilage matrix catabolic enzymes including MMPs and ADAMTS5. schizandrin A 14-27 interleukin 1 beta Rattus norvegicus 42-50 30761007-14 2019 Moreover, the IL-1beta-induced downregulation of Collagen II, aggrecan, and Sox9 could be ameliorated by Schisandrin A. schizandrin A 105-118 interleukin 1 beta Rattus norvegicus 14-22 30761007-17 2019 In conclusion, this study elucidates that Schisandrin A inhibits the IL-1beta-induced inflammation and cartilage degradation via suppression of MAPK and NF-kappaB signal pathways, indicating its potential role in OA therapy. schizandrin A 42-55 interleukin 1 beta Rattus norvegicus 69-77 30997025-8 2019 Also, mRNA expression levels of TNF-alpha, IL-1beta, and IL-6 in the brain, liver, and testes of rats were augmented, whereas IL-10 was decreased with BPA treatment. bisphenol A 151-154 interleukin 1 beta Rattus norvegicus 43-51 30774454-4 2019 Results: In cell culture, both CMC 2.24 and curcumin appeared similarly effective in suppressing LPS-induced cytokine (IL-1beta and TNF-alpha) secretion by mononuclear inflammatory cells; however, CMC 2.24 significantly reduced MMP-9 secretion by 78% (P<0.05) whereas curcumin was ineffective. Curcumin 44-52 interleukin 1 beta Rattus norvegicus 119-127 30641903-4 2019 The results showed that sterone significantly inhibited the morphological changes, the up-regulation of inflammatory biomarker ionized calcium-binding adapter molecule 1 (Iba-1), and the mRNA increase of proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) induced by lipopolysaccharide (LPS) in BV2 microglia and RAW264.7 macrophages. sterone 24-31 interleukin 1 beta Rattus norvegicus 261-278 30723690-0 2019 Acute glufosinate-based herbicide treatment in rats leads to increased ocular interleukin-1beta and c-Fos protein levels, as well as intraocular pressure. phosphinothricin 6-17 interleukin 1 beta Rattus norvegicus 78-95 30723690-7 2019 The results established that the glufosinate-based herbicide significantly increased IL-1beta and c-Fos immunopositivity in the optic nerve (p < 0.05), concomitant with increased IOP. phosphinothricin 33-44 interleukin 1 beta Rattus norvegicus 85-93 30550883-8 2019 KEY FINDINGS: The zeranol administered group showed a reversal of neuronal damage caused by ischemia evidenced by the decrease in MDA, IL-1beta, TNF-alpha, and MMP-9 levels, increase GSH, and ATP levels, decrease expression of iNOS in both regions cortex and hippocampus, increase protein level of p-CREB, GLUT-3 and BDNF, increase number of intact neuron cells in both regions and attenuated histological changes in both cortex and hippocampus regions. Zeranol 18-25 interleukin 1 beta Rattus norvegicus 135-143 30547177-6 2019 Furthermore, the expression levels of VEGF and inflammation-related iNOS, IL-6, IL-1beta, and TNF-alpha were significantly down-regulated in the ginsenoside Rf groups in a dose-dependent manner. ginsenoside Rf 145-159 interleukin 1 beta Rattus norvegicus 80-88 30641903-4 2019 The results showed that sterone significantly inhibited the morphological changes, the up-regulation of inflammatory biomarker ionized calcium-binding adapter molecule 1 (Iba-1), and the mRNA increase of proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) induced by lipopolysaccharide (LPS) in BV2 microglia and RAW264.7 macrophages. sterone 24-31 interleukin 1 beta Rattus norvegicus 280-288 30634696-7 2019 DCA induced changes in the colonic immune response characterized by increased expression of the cytokine Il-1beta and the inducible enzyme Cox-2, which was reduced by the treatments. Deoxycholic Acid 0-3 interleukin 1 beta Rattus norvegicus 105-113 30393232-4 2019 Under the induction of THS, gut barrier failure was characterized by injury of permeability and mucus layer, which were companied by the decreased expression of zonula occludens-1 in the colon and increased levels of inflammatory factors including tumor necrosis factor-alpha, interferon-gamma, interleukin (IL)-6, and IL-1beta in the serum. THYMIDINE-5'-(DITHIO)PHOSPHATE 23-26 interleukin 1 beta Rattus norvegicus 319-327 30657854-7 2019 Results: Our results showed that hyperglycemia greatly increased inflammation in diabetic rats or HRECs exposed to high glucose, increasing the levels of caspase-1, interleukin-1beta (IL-1beta) and IL-18. Glucose 120-127 interleukin 1 beta Rattus norvegicus 165-182 30666189-0 2018 Neuroprotective Effects of Curcumin on IL-1beta-Induced Neuronal Apoptosis and Depression-Like Behaviors Caused by Chronic Stress in Rats. Curcumin 27-35 interleukin 1 beta Rattus norvegicus 39-47 30666189-5 2018 Our results show that chronic administration of curcumin (40 mg/kg, i.p., 5 weeks) prior to stress exposure significantly alleviated depression-like behaviors, expression of the proinflammatory cytokine interleukin-1beta (IL-1beta) and inhibited neuronal apoptosis within neurons of the ventromedial prefrontal cortex (vmPFC). Curcumin 48-56 interleukin 1 beta Rattus norvegicus 203-220 30666189-5 2018 Our results show that chronic administration of curcumin (40 mg/kg, i.p., 5 weeks) prior to stress exposure significantly alleviated depression-like behaviors, expression of the proinflammatory cytokine interleukin-1beta (IL-1beta) and inhibited neuronal apoptosis within neurons of the ventromedial prefrontal cortex (vmPFC). Curcumin 48-56 interleukin 1 beta Rattus norvegicus 222-230 30666189-7 2018 More important, within the vmPFC of wild type rats, overexpression of IL-1beta via intracerebral infusion of AAV-IL-1beta induced p38 MAPK phosphorylation and neuronal apoptosis, which could be significantly prevented by chronic treatment of curcumin. Curcumin 242-250 interleukin 1 beta Rattus norvegicus 70-78 30666189-7 2018 More important, within the vmPFC of wild type rats, overexpression of IL-1beta via intracerebral infusion of AAV-IL-1beta induced p38 MAPK phosphorylation and neuronal apoptosis, which could be significantly prevented by chronic treatment of curcumin. Curcumin 242-250 interleukin 1 beta Rattus norvegicus 113-121 30666189-8 2018 Collectively, these findings reveal that curcumin protects against IL-1beta-induced neuronal apoptosis, which may be related to the display of depression-like behaviors in stressed rats. Curcumin 41-49 interleukin 1 beta Rattus norvegicus 67-75 30814084-9 2019 In addition, the levels of inflammatory cytokines TGF-beta1, TNF-alpha and IL-1beta of the model group were remarkably higher than those in the control group (p<0.01), while after being treated with dioscin these cytokines were obviously decreased (p<0.05). dioscin 202-209 interleukin 1 beta Rattus norvegicus 75-83 30569967-5 2019 In addition, carrageenan-induced pleurisy caused a significant increase in pro-inflammatory cytokines mRNA expressions (TNF-alpha, IL-1beta, and NF-KB), while Aliskiren administration decreased their expressions as well as the standard treatments, indomethacin and dexamethasone, did. Carrageenan 13-24 interleukin 1 beta Rattus norvegicus 131-139 30569967-5 2019 In addition, carrageenan-induced pleurisy caused a significant increase in pro-inflammatory cytokines mRNA expressions (TNF-alpha, IL-1beta, and NF-KB), while Aliskiren administration decreased their expressions as well as the standard treatments, indomethacin and dexamethasone, did. aliskiren 159-168 interleukin 1 beta Rattus norvegicus 131-139 30213522-5 2019 This function of paeonol might be correlated with its ability to reduce inflammatory factors (IL-1beta, IL-6 and TNF-alpha) and alleviate oxidative stress (SOD, MDA, GSH and ROS) in gingival tissues. paeonol 17-24 interleukin 1 beta Rattus norvegicus 94-102 30551424-9 2019 Moreover, elevated levels of pro-inflammatory cytokines IL-1beta, IL-6, TNF-alpha and liver biomarkers ALT, AST were also significantly reversed by CPE (50, and 100 mg/kg) or fluoxetine administration in the CUMS-exposed rats. Fluoxetine 175-185 interleukin 1 beta Rattus norvegicus 56-64 30551412-11 2019 In this study, luteolin considerably reduced the IL-1beta-induced production of NO, PGE2, TNF-alpha, MMP-2, MMP-8 and MMP-9 and the expression of COX-2, iNOS, MMP-1, MMP-3 and MMP-13. Dinoprostone 84-88 interleukin 1 beta Rattus norvegicus 49-57 30551518-9 2019 DOX-treated rats showed significantly higher tumor necrosis factor-alpha and interleukin-1beta. Doxorubicin 0-3 interleukin 1 beta Rattus norvegicus 77-94 30551415-6 2019 Our findings suggest that kaempferol inhibits hyperglycemia-induced activation of RhoA and decreased oxidative stress, pro-inflammatory cytokines (TNF-alpha and IL-1beta) and fibrosis (TGF-beta1 expression, extracellular matrix protein expression) in NRK-52E and RPTEC cells. kaempferol 26-36 interleukin 1 beta Rattus norvegicus 161-169 30291853-12 2019 IL-1beta was found to be highly expressed in B10 cells, and its co-culture with HMO6 further increased that in B10. hmo6 80-84 interleukin 1 beta Rattus norvegicus 0-8 30261305-8 2019 Moreover, H2 caused a reduction in surges of proinflammatory cytokines (plasma TNF-alpha and IL-1beta) and prostaglandin E2 [(PGE2), in plasma and hypothalamus], and an increase in plasma IL-10. Hydrogen 10-12 interleukin 1 beta Rattus norvegicus 93-101 31114432-2 2019 In our previous work, we found the inhibitory effect of maprotiline on inflammatory mediator"s expression like tumor necrosis factor alpha (TNF-alpha and interleukin 1beta (IL-1beta. Maprotiline 56-67 interleukin 1 beta Rattus norvegicus 154-171 31114432-2 2019 In our previous work, we found the inhibitory effect of maprotiline on inflammatory mediator"s expression like tumor necrosis factor alpha (TNF-alpha and interleukin 1beta (IL-1beta. Maprotiline 56-67 interleukin 1 beta Rattus norvegicus 173-181 30551445-7 2019 Concurrently, Nox1/4 dual inhibitor GKT137831 reduced the protein and mRNA levels of proinflammatory cytokines interleukin 1beta (IL-1beta), IL-6, and TNF-alpha in the left ventricle of AAC-induced hypertensive rats. setanaxib 36-45 interleukin 1 beta Rattus norvegicus 111-128 30551445-7 2019 Concurrently, Nox1/4 dual inhibitor GKT137831 reduced the protein and mRNA levels of proinflammatory cytokines interleukin 1beta (IL-1beta), IL-6, and TNF-alpha in the left ventricle of AAC-induced hypertensive rats. setanaxib 36-45 interleukin 1 beta Rattus norvegicus 130-138 30148435-10 2019 By contrast, methotrexate significantly reduced plasma IL-1beta and TNF-alpha levels and increased serum BMP-4 level. Methotrexate 13-25 interleukin 1 beta Rattus norvegicus 55-63 31713483-9 2019 Intrathecal injection of miR-212-3p agomir into CCI rats improved the PWT and PWL, decreased the IL-1beta, IL-6 and TNF-alpha, decreased the expression levels of BCL2 associated X, apoptosis regulator (Bax), cleaved caspase-3 and increased the expression levels BCL2 apoptosis regulator (Bcl-2). 6-chloro-2-(1-piperazinyl)pyrazine 29-42 interleukin 1 beta Rattus norvegicus 97-105 30365041-8 2019 Furthermore, CZ2HF reduced TNF-alpha, IL-1beta, COX-2 protein expression levels, Bax/Bcl-2 ratio, and reduced Abeta1-42 and active-caspase-3 levels. cz2hf 13-18 interleukin 1 beta Rattus norvegicus 38-46 30502652-6 2019 Luteoloside significantly inhibited I/R-induced neuroinflammation, as demonstrated by reduced levels of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the brain tissues of MCAO rats. luteolin-7-glucoside 0-11 interleukin 1 beta Rattus norvegicus 104-121 30502652-6 2019 Luteoloside significantly inhibited I/R-induced neuroinflammation, as demonstrated by reduced levels of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the brain tissues of MCAO rats. luteolin-7-glucoside 0-11 interleukin 1 beta Rattus norvegicus 123-131 31288723-8 2019 RESULTS: Carvacrol treatment, and AdVshTRPM7 infection were both efficient at inhibiting the production of pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6 and IL-12 induced by endotoxemia, without changes in the levels of the anti-inflammatory cytokines IL-10 and IL-4. carvacrol 9-18 interleukin 1 beta Rattus norvegicus 145-153 30387830-13 2019 In addition, rhBMP2 inhibited cell apoptosis via upregulating the phosphorylation levels of the PI3K/Akt signaling pathway, and LY29400 pretreatment inhibited the effects of BMP2 in IL-1beta treated NP cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 128-135 interleukin 1 beta Rattus norvegicus 182-190 30054785-5 2019 In the CIA rats, repeated koumine treatments significantly reduced pain compared to controls and attenuated the collagen-induced increase in levels of glial fibrillary acidic protein (GFAP) and the pro-inflammatory cytokines tumour necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta). koumine 26-33 interleukin 1 beta Rattus norvegicus 270-287 30815381-3 2019 The aim of this study was to prove the efficacy of quercetin-loaded lecithin-chitosan nanoparticles on the OA model rats by observed its effect on interleukin (IL-1) beta, MMP-9, MMP-13, and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-5) expressions. Quercetin 51-60 interleukin 1 beta Rattus norvegicus 160-170 30815381-3 2019 The aim of this study was to prove the efficacy of quercetin-loaded lecithin-chitosan nanoparticles on the OA model rats by observed its effect on interleukin (IL-1) beta, MMP-9, MMP-13, and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-5) expressions. lecithin-chitosan 68-85 interleukin 1 beta Rattus norvegicus 160-170 30353660-11 2019 Together, the data indicated that the knockdown of Mincle in microglia within the PVN prevents VAs by attenuating sympathetic hyperactivity and ventricular susceptibility, in part by inhibiting its downstream NLRP3/IL-1beta axis following MI. vas 95-98 interleukin 1 beta Rattus norvegicus 215-223 30054785-5 2019 In the CIA rats, repeated koumine treatments significantly reduced pain compared to controls and attenuated the collagen-induced increase in levels of glial fibrillary acidic protein (GFAP) and the pro-inflammatory cytokines tumour necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta). koumine 26-33 interleukin 1 beta Rattus norvegicus 289-297 31117104-8 2019 RESULTS: Compared with DN group, the levels of TNF-alpha, IL-6, IL-1beta, and MCP-1 were decreased in the PS-H group (p < 0.05). ps-h 106-110 interleukin 1 beta Rattus norvegicus 64-72 30066041-8 2019 Inflammatory markers IL-1beta, IL-6, and MCP-1 were also raised in the urine of hyperoxaluric rats which were significantly decreased by 4-PBA treatment. 4-phenylbutyric acid 137-142 interleukin 1 beta Rattus norvegicus 21-29 30726810-7 2019 Immunoblot analysis indicated increasing trend of NF-kappaB activation, and real-time PCR analysis showed increasing tendency of TNFalpha and IL-1beta, as well as MUC1 and 5B, in NaHS-administered rat lung. sodium bisulfide 179-183 interleukin 1 beta Rattus norvegicus 142-150 29725905-6 2019 Animals treated with 8 mg/kg JM-20 (p.o., 1 h after reperfusion) showed minimal neurological impairment and lower GABA and IL-1beta levels in CSF when compared to damaged rats that received vehicle. jm-20 29-34 interleukin 1 beta Rattus norvegicus 123-131 30240048-9 2019 Exposure of EGC to pro-inflammatory cytokines (IL-1beta and/or TNFalpha) induced an upregulation of all IL-7 isoforms. (-)-Epigallocatechin 12-15 interleukin 1 beta Rattus norvegicus 47-55 31245947-10 2019 CONCLUSION: Compound Bianyanning can promote the recovering process of acute pharyngitis, improve the morphology of lungs and bronchus, which may be related to inhibiting the releasing of the IL-1beta and TNF-alpha in serum. bianyanning 21-32 interleukin 1 beta Rattus norvegicus 192-200 30463494-10 2019 With damage to the splenocyte structure and DNA, the protein expression levels of IL-1beta, IL-2, IL-6, and TNF-alpha were significantly downregulated by exposure to fluoride. Fluorides 166-174 interleukin 1 beta Rattus norvegicus 82-90 31377033-4 2019 Following administration, 2000 and 4000 mg/kg body weight camphor significantly increase liver and lung levels of tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta) and interleukin 6 (IL-6) in a dose dependent manner compared with control, while interleukin 10 (IL-10) levels were significantly increased only by 1000 and 4000 mg/kg body weight camphor in liver and lung respectively, compared with control. Camphor 58-65 interleukin 1 beta Rattus norvegicus 155-173 31377033-4 2019 Following administration, 2000 and 4000 mg/kg body weight camphor significantly increase liver and lung levels of tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta) and interleukin 6 (IL-6) in a dose dependent manner compared with control, while interleukin 10 (IL-10) levels were significantly increased only by 1000 and 4000 mg/kg body weight camphor in liver and lung respectively, compared with control. Camphor 58-65 interleukin 1 beta Rattus norvegicus 175-183 30394303-4 2019 At the same time, pirfenidone also reduced the level of TNF-alpha, IL-1beta, IL-6 in lung tissues and the protein expression of collagen I. pirfenidone 18-29 interleukin 1 beta Rattus norvegicus 67-75 30687544-7 2018 Concentration of interleukin (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and interferon gamma (INF-gamma) was reduces in stachydrine treated group than TBI group. stachydrine 129-140 interleukin 1 beta Rattus norvegicus 30-38 31303407-6 2019 Exenatide pretreatment improved renal function survival rate with lower scores of acute tubular necrosis, infiltrating macrophages, and interstitial fibrosis as well as reduced messenger RNA expression of inflammatory mediators (tumor necrosis factor alpha, interleukin-6, interleukin-1beta, and intercellular adhesion molecule-1) after KTx. Exenatide 0-9 interleukin 1 beta Rattus norvegicus 273-290 30564065-0 2018 Transient receptor potential ankyrin 1 (trpa1) mediates il-1beta-induced apoptosis in rat chondrocytes via calcium overload and mitochondrial dysfunction. Calcium 107-114 interleukin 1 beta Rattus norvegicus 56-64 30693069-5 2018 The aim of this study is to evaluate the effect of curcumin in preventive and therapeutic approaches against oxidative damage, NF-kappaB activation, and the rise in serum levels of IL-1beta and TNF-alpha induced by acute and chronic exposure to ozone in rat hippocampus. Curcumin 51-59 interleukin 1 beta Rattus norvegicus 181-189 30693069-5 2018 The aim of this study is to evaluate the effect of curcumin in preventive and therapeutic approaches against oxidative damage, NF-kappaB activation, and the rise in serum levels of IL-1beta and TNF-alpha induced by acute and chronic exposure to ozone in rat hippocampus. Ozone 245-250 interleukin 1 beta Rattus norvegicus 181-189 30237062-4 2018 In this study, we investigated the effect of GADD45beta-I, a cell-permeable inhibitor targeted for MKK7, on IL-1beta-induced cytotoxicity in rat chondrocytes. gadd45beta-i 45-57 interleukin 1 beta Rattus norvegicus 108-116 30237062-11 2018 In conclusion, our data indicated that GADD45beta-I protected chondrocytes against IL-1beta through Sirt3-mediated inhibition of ER stress. gadd45beta-i 39-51 interleukin 1 beta Rattus norvegicus 83-91 30397060-5 2019 Rutin also significantly attenuated VCM-induced oxidative stress, inflammatory cell infiltration, apoptosis, and decreased interleukin-1beta and tumor necrosis factor alpha levels (all P < 0.05 or 0.01) in kidneys. Rutin 0-5 interleukin 1 beta Rattus norvegicus 123-140 30397060-5 2019 Rutin also significantly attenuated VCM-induced oxidative stress, inflammatory cell infiltration, apoptosis, and decreased interleukin-1beta and tumor necrosis factor alpha levels (all P < 0.05 or 0.01) in kidneys. Vancomycin 36-39 interleukin 1 beta Rattus norvegicus 123-140 30557884-10 2018 Hesperidin also reversed the activity of H2O2 on inhibiting the Col2a1, aggrecan, and SOX9 gene expression and increasing the gene expression of caspase 3, IL-1beta, TNFalpha, iNOS, and MMP13. Hesperidin 0-10 interleukin 1 beta Rattus norvegicus 156-164 30557884-10 2018 Hesperidin also reversed the activity of H2O2 on inhibiting the Col2a1, aggrecan, and SOX9 gene expression and increasing the gene expression of caspase 3, IL-1beta, TNFalpha, iNOS, and MMP13. Hydrogen Peroxide 41-45 interleukin 1 beta Rattus norvegicus 156-164 30557884-11 2018 In addition, hesperidin administration markedly attenuated cartilage destruction and reduced IL-1beta and TNF-alpha levels in a surgically-induced OA model. Hesperidin 13-23 interleukin 1 beta Rattus norvegicus 93-101 30511573-6 2018 Furthermore, immunoblotting indicated that resveratrol downregulated the increase in the levels of hypoxia-inducible factor-1alpha (HIF-1alpha) and that of the activated phosphorylation of p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase in IL-1beta-stimulated RSC-364 cells. Resveratrol 43-54 interleukin 1 beta Rattus norvegicus 264-272 30248332-8 2018 The expression of iNOS, COX-2, TNF-alpha and IL-1beta, were also suppressed by dexamethasone delivered 30 min (but not 60 min) after MCAO. Dexamethasone 79-92 interleukin 1 beta Rattus norvegicus 45-53 30651902-8 2018 Intrathecal administration of 10 mug/mL, 20 mug/mL, or 30 mug/mL oxygen/ozone significantly attenuated the decreased mechanical PWTs, downregulated the overexpression of spinal TNF-alpha, IL-1beta, and IL-6, and increased the expression of cGMP and cAMP in chronic radiculitis rats. Oxygen 65-71 interleukin 1 beta Rattus norvegicus 188-196 30997021-7 2019 Both maternal caffeine doses caused a marked attenuation in the values of fetal serum GH, IGF-II, VEGF, TGF-beta, TNF-alpha, IL-1beta, IL-6, leptin and MCP-1, and a noticeable elevation in the value of fetal serum adiponectin at ED 20. Caffeine 14-22 interleukin 1 beta Rattus norvegicus 125-133 30618728-12 2018 Crocetin treatment increased the level of red blood cells (RBC), hemoglobin (Hb) and decreased level of white blood cells (WBC), erythrocyte sedimentation rate (ESR), alkaline phosphatase (ALP), serum glutamic pyruvic transaminase (SGPT), and serum glutamic-oxaloacetic transaminase (SGOT) parameters, with reduction of TNF-alpha, IL-6, and IL-1beta.The protective effect of crocetin was substantiated with a reduction in expression of IL-6, IL-1beta, VEGF, and TNF-R1, respectively. crocetin 0-8 interleukin 1 beta Rattus norvegicus 341-349 30618728-12 2018 Crocetin treatment increased the level of red blood cells (RBC), hemoglobin (Hb) and decreased level of white blood cells (WBC), erythrocyte sedimentation rate (ESR), alkaline phosphatase (ALP), serum glutamic pyruvic transaminase (SGPT), and serum glutamic-oxaloacetic transaminase (SGOT) parameters, with reduction of TNF-alpha, IL-6, and IL-1beta.The protective effect of crocetin was substantiated with a reduction in expression of IL-6, IL-1beta, VEGF, and TNF-R1, respectively. crocetin 0-8 interleukin 1 beta Rattus norvegicus 442-450 30412724-10 2018 KEY FINDINGS: Septic rats demonstrated risen levels of IL-1beta, IL-6, IL-10, AST, ALT and gamma-GT, while treatment with dexamethasone or MMF attenuated these levels. citraconic acid 139-142 interleukin 1 beta Rattus norvegicus 55-63 30534634-0 2018 The inhibitory effects of rosmarinic acid on catabolism induced by IL-1beta in rat chondrocyte. rosmarinic acid 26-41 interleukin 1 beta Rattus norvegicus 67-75 30514296-0 2018 The treatment value of IL-1beta monoclonal antibody under the targeting location of alpha-methyl-L-tryptophan and superparamagnetic iron oxide nanoparticles in an acute temporal lobe epilepsy model. alpha-methyltryptophan 84-109 interleukin 1 beta Rattus norvegicus 23-31 30514296-0 2018 The treatment value of IL-1beta monoclonal antibody under the targeting location of alpha-methyl-L-tryptophan and superparamagnetic iron oxide nanoparticles in an acute temporal lobe epilepsy model. ferric oxide 132-142 interleukin 1 beta Rattus norvegicus 23-31 30559669-8 2018 Tissue increments of myeloperoxidase, tumor necrosis factor and interleukin-1beta were more effectively counteracted by INF39 and DEX, than YVAD and anakinra. Dexamethasone 130-133 interleukin 1 beta Rattus norvegicus 64-81 30564103-9 2018 Importantly, ethanol-induced Cx43 hemichannel and Panx1 channel activity was correlated with increased levels of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), IL-6 in the hippocampus, as well as with profound alterations in astrocyte arbor complexity. Ethanol 13-20 interleukin 1 beta Rattus norvegicus 113-130 30564103-9 2018 Importantly, ethanol-induced Cx43 hemichannel and Panx1 channel activity was correlated with increased levels of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), IL-6 in the hippocampus, as well as with profound alterations in astrocyte arbor complexity. Ethanol 13-20 interleukin 1 beta Rattus norvegicus 132-140 29482467-11 2018 CONCLUSION: Oral fluvastatin application could reduce formation of intra-abdominal adhesion by promoting expression of MMP-9 level, lowering the levels of IL-1beta and increasing the activity of t-PA after abdominal surgery. Fluvastatin 17-28 interleukin 1 beta Rattus norvegicus 155-163 30513893-7 2018 Moreover, it neurochemically reverses the SPS increase in pro-inflammatory cytokines; thus, IL-1beta and IFN-gamma can be further blocked by the OXT antagonist atosiban (ASB) in the hippocampus. atosiban 160-168 interleukin 1 beta Rattus norvegicus 92-100 30513893-7 2018 Moreover, it neurochemically reverses the SPS increase in pro-inflammatory cytokines; thus, IL-1beta and IFN-gamma can be further blocked by the OXT antagonist atosiban (ASB) in the hippocampus. atosiban 170-173 interleukin 1 beta Rattus norvegicus 92-100 30513893-8 2018 Peripheral profiles revealed a similar response pattern to SPS of OXT and corticosterone (CORT), and the SPS-induced increase in plasma levels of IL-1beta and TNF-alpha could be reduced by OXT. Sodium phenolsulfonate 105-108 interleukin 1 beta Rattus norvegicus 146-154 30484291-1 2018 BACKGROUND: Oxidative stress and interleukin-1 beta (IL-1beta) have been reported to play a role in the pathogenesis of nephrotoxicity induced by cisplatin. Cisplatin 146-155 interleukin 1 beta Rattus norvegicus 33-51 29795135-9 2018 Moreover, SAA dose-dependently inhibited the activation of nuclear factor-kappaB (NF-kappaB) and p38 mitogen-activated protein kinase (MAPK) signaling pathways, subsequently attenuating the secretion of tumor necrosis factor-alpha and interleukin-1beta and inhibiting the expression of monocyte chemotactic protein-1, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in kidneys of 5/6Nx rats. salvianolic acid A 10-13 interleukin 1 beta Rattus norvegicus 235-252 30484291-1 2018 BACKGROUND: Oxidative stress and interleukin-1 beta (IL-1beta) have been reported to play a role in the pathogenesis of nephrotoxicity induced by cisplatin. Cisplatin 146-155 interleukin 1 beta Rattus norvegicus 53-61 30484291-2 2018 OBJECTIVES: The objective of this study was to investigate the effect of anakinra, which is an IL-1beta receptor antagonist, on cisplatin-induced nephrotoxicity in rats, through biochemical, gene expression and histopathological analyses. Cisplatin 128-137 interleukin 1 beta Rattus norvegicus 95-103 30484291-10 2018 Cisplatin also increased IL-1beta gene expression (6.33 +-0.27 gene expression levels; p < 0.001) compared to other groups. Cisplatin 0-9 interleukin 1 beta Rattus norvegicus 25-33 30484291-11 2018 The impact of anakinra on the MDA and tGSH levels, and on IL-1beta gene expression induced by cisplatin was observed as a reversal of these findings (p < 0.05). Cisplatin 94-103 interleukin 1 beta Rattus norvegicus 58-66 30268893-7 2018 Preliminary pharmacodynamics studies indicated that the group of high-dose TCA-loaded (200 mg kg-1) hexagonal liquid crystal was shown to inhibit the paw swelling of AA rats, improve synovial hyperplasia and inflammatory cell infiltration, and down-regulate the levels of serum interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha. cinnamaldehyde 75-78 interleukin 1 beta Rattus norvegicus 278-300 30575935-9 2018 Moreover, compared with ISO group, OPZ treatment significantly reduced the levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). oltipraz 35-38 interleukin 1 beta Rattus norvegicus 164-181 30575935-9 2018 Moreover, compared with ISO group, OPZ treatment significantly reduced the levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). oltipraz 35-38 interleukin 1 beta Rattus norvegicus 183-191 30412853-0 2018 Corrigendum to "Alpha-Mangostin suppresses interleukin-1beta-induced apoptosis in rat chondrocytes by inhibiting the NF-kappaB signaling pathway and delays the progression of osteoarthritis in a rat model" [Int. mangostin 16-31 interleukin 1 beta Rattus norvegicus 43-60 30584274-9 2018 Curcumin and rapamycin treatment inhibited the increased levels of proinflammatory cytokines including IL-1beta, TNF-alpha, MMP-1, and MMP-3 in CIA rats. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 103-111 30584274-9 2018 Curcumin and rapamycin treatment inhibited the increased levels of proinflammatory cytokines including IL-1beta, TNF-alpha, MMP-1, and MMP-3 in CIA rats. Sirolimus 13-22 interleukin 1 beta Rattus norvegicus 103-111 30185127-4 2018 Additionally, a significant increase in liver triglyceride concentration was found, accompanied by upregulation of hepatic fatty acid synthase expression in the rats fed the HS-MID diet compared to those in the rats fed an HS-IA diet, although no difference was observed in plasma transaminase activity and hepatic interleukin-1beta expression. Triglycerides 46-58 interleukin 1 beta Rattus norvegicus 315-332 30054234-11 2018 After administration of BCA, retina concentrations of vascular endothelial growth factor, tumor necrosis factor-alpha and interleukin-1beta decreased in the 2 groups of treated rats with diabetes compared to the control group with diabetes (p<0.05). biochanin A 24-27 interleukin 1 beta Rattus norvegicus 122-139 30054234-13 2018 CONCLUSIONS: Administration of BCA can improve and postpone retinopathy by lowering blood sugar, suppressing inflammation via decreasing tumor necrosis factor-alpha and interleukin-1beta, and reducing angiogenesis via decreasing vascular endothelial growth factor in the retinal tissues. biochanin A 31-34 interleukin 1 beta Rattus norvegicus 169-186 30312597-2 2018 The expression levels of NgR, IL-1beta, and TNF-alpha in rat MCs were detected by QPCR and Immunoblotting assays. mcs 61-64 interleukin 1 beta Rattus norvegicus 30-38 30542446-4 2018 GW405833 also inhibited the increase of MPO activity, the recruitment of total leukocytes and neutrophils, and MDA concentration during carrageenan-induced acute inflammation, along with reversed nearly to the normal levels the increased of TNF-alpha, and IL-1beta in serum. 1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole 0-8 interleukin 1 beta Rattus norvegicus 256-264 30542446-6 2018 The mechanism of GW405833"s suppression of inflammation is supported by these results, which are achieved by the inhibition of neutrophil migration, which regulates the reduction of oxidative stress, TNF-alpha and IL-1beta levels. 1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole 17-25 interleukin 1 beta Rattus norvegicus 214-222 30088170-5 2018 When compared to rats with PQ-induced lung injuries, rats pretreated with fasudil had significantly fewer polymorphonuclear neutrophils and lower concentrations of protein, TNF-alpha, IL-1beta, and IL-6 in their bronchoalveolar lavage fluid. fasudil 74-81 interleukin 1 beta Rattus norvegicus 184-192 30591891-11 2018 In rats with CFA-induced arthritis, CCHE treatment significantly reduced joint swelling as well as IL-1beta and TNF-alpha levels (p < 0.01). cche 36-40 interleukin 1 beta Rattus norvegicus 99-107 30401827-7 2018 Pro-inflammatory cytokines (IL-1b, IL-12, INFgamma) were also decreased in serum of DIO rats treated with C60 fullerenes while anti-inflammatory cytokines (IL-4, IL-10) were at the control levels. fullerene C60 106-120 interleukin 1 beta Rattus norvegicus 28-33 30129059-6 2018 It was also found that the levels of inflammation and oxidative stress in STZ-induced DM were both enhanced, as evidenced by a decreased level of catalase, superoxide dismutase, glutathione peroxidase, as well as increased levels of malonyldialdehyde, interleukin-1beta (IL-1beta), and IL-6. Streptozocin 74-77 interleukin 1 beta Rattus norvegicus 252-269 30129059-6 2018 It was also found that the levels of inflammation and oxidative stress in STZ-induced DM were both enhanced, as evidenced by a decreased level of catalase, superoxide dismutase, glutathione peroxidase, as well as increased levels of malonyldialdehyde, interleukin-1beta (IL-1beta), and IL-6. Streptozocin 74-77 interleukin 1 beta Rattus norvegicus 271-279 30156477-11 2018 Real-time PCR showed that RSV significantly suppressed the upregulation of the inflammatory factors IL-1beta, TNFalpha, COX2 mRNA levels. Resveratrol 26-29 interleukin 1 beta Rattus norvegicus 100-108 29693453-3 2018 Meanwhile, ZJ01 suppressed LPS-induced production of ROS and the mRNA levels of pro-inflammatory cytokines TNF-alpha, IL-1beta and IL-6 in H9c2 cardiac cells. zj01 11-15 interleukin 1 beta Rattus norvegicus 118-126 29611100-8 2018 Infected rats treated with RSV had lower apoptotic scores and IL-1beta, CCL2, and CCL3 levels when compared to the infected group receiving placebo. Resveratrol 27-30 interleukin 1 beta Rattus norvegicus 62-70 30626474-6 2018 Results Glutamine alleviated lung inflammation response and cell apoptosis, and reduced the levels of IL-1beta and TNF-alpha in the inflammatory lung tissues of premature rats. Glutamine 8-17 interleukin 1 beta Rattus norvegicus 102-110 30026598-2 2018 ATP-induced activation of P2X7 results in IL-1beta release causing neuroinflammation and microglial activation. Adenosine Triphosphate 0-3 interleukin 1 beta Rattus norvegicus 42-50 30026598-7 2018 The P2X7 antagonist (3 mg/kg, oral) blocked Bz-ATP-induced brain IL-1beta release in conscious rats, demonstrating functional effects of target engagement in the brain. Quinuclidinyl Benzilate 44-46 interleukin 1 beta Rattus norvegicus 65-73 30026598-7 2018 The P2X7 antagonist (3 mg/kg, oral) blocked Bz-ATP-induced brain IL-1beta release in conscious rats, demonstrating functional effects of target engagement in the brain. Adenosine Triphosphate 47-50 interleukin 1 beta Rattus norvegicus 65-73 30003825-16 2018 DMY decreased the serum level of NO, MDA, IL-1beta and TNF-alpha, which had increased in LPS rats. dihydromyricetin 0-3 interleukin 1 beta Rattus norvegicus 42-50 30317129-5 2018 RESULTS: The injection of carrageenan in the gastrocnemius muscle increased tissue myeloperoxidase (MPO) activity (p < 0.001), edema (p < 0.001) and the levels of tumoral necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, macrophage inflammatory protein (MIP-2), but not IL-10 levels. Carrageenan 26-37 interleukin 1 beta Rattus norvegicus 206-228 30317129-8 2018 Animals pretreated with betaCD-carvacrol (160 mg/kg) presented significantly lower levels of IL-1beta, IL-6 and MIP-2 and higher levels of IL-10 six hours after induction and lower levels of TNF-alpha and MIP-2 after 24 h when compared to the vehicle group. betacd-carvacrol 24-40 interleukin 1 beta Rattus norvegicus 93-101 30092388-6 2018 At low Cd dose inflammatory response (nitric oxide and IL-1beta) was observed. Cadmium 7-9 interleukin 1 beta Rattus norvegicus 55-63 30555323-7 2018 Diclofenac induced intestinal damage and inflammation, triggering an increase in tissue concentrations of tumor necrosis factor and interleukin-1beta, higher expression of TLR-2 and TLR-4, MyD88, NF-kappaB and activation of caspase-1. Diclofenac 0-10 interleukin 1 beta Rattus norvegicus 132-149 30568481-0 2018 Ozone induces autophagy in rat chondrocytes stimulated with IL-1beta through the AMPK/mTOR signaling pathway. Ozone 0-5 interleukin 1 beta Rattus norvegicus 60-68 30496326-8 2018 Tranexamic acid treatment was associated with a significant decrease in serum IL-1beta at six and 24 hours and IL-10 at 24 hours from start of shock compared to vehicle control. Tranexamic Acid 0-15 interleukin 1 beta Rattus norvegicus 78-86 30568481-13 2018 Moreover, ozone treatment suppressed inflammation and helped maintain metabolic balance in chondrocytes stimulated with IL-1beta. Ozone 10-15 interleukin 1 beta Rattus norvegicus 120-128 30475883-9 2018 The analysis of the cytokines in the conditioned media revealed an increase in IL-1beta, IL-6 and TNFalpha under hyperglycemic conditions, which reverted to the basal concentration in co-cultures maintained in the presence of dexamethasone. Dexamethasone 226-239 interleukin 1 beta Rattus norvegicus 79-87 30470240-10 2018 We found that treatment of astrocytes with M8I significantly inhibited LTA-induced expression of iNOS, TNF-alpha, IL-1beta, IL-6, and TLR-2. m8i 43-46 interleukin 1 beta Rattus norvegicus 114-122 30352244-10 2018 As to the mechanisms, the CLP-induced increases in oxidative stress and lipid peroxidation levels and TNF-alpha and IL-1beta mRNA and protein expressions were subsequently attenuated by propofol. Propofol 186-194 interleukin 1 beta Rattus norvegicus 116-124 30662599-4 2018 Moreover, treatment with DSS significantly reduced the levels of IL-1beta, IL-6, and tumor necrosis factor (TNF)-alpha in serum and in the ischemic penumbra. dss 25-28 interleukin 1 beta Rattus norvegicus 65-73 30405207-7 2018 VPA lowered CCI-induced inflammatory proteins (pNFkappaB, iNOS and COX-2), pro-apoptotic proteins (pAKT/AKT and pGSK-3beta/GSK-3beta), proinflammatory cytokines (TNF-alpha and IL-1beta) and nuclear pNFkappaB activation in the SN, DRG and SC in CCI rats. Valproic Acid 0-3 interleukin 1 beta Rattus norvegicus 176-184 30268781-0 2018 Curcumin Protects Against Chronic Stress-induced Dysregulation of Neuroplasticity and Depression-like Behaviors via Suppressing IL-1beta Pathway in Rats. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 128-136 30473883-7 2018 Myricetin effectively prevented IOP elevation in glaucoma-induced rats and decreased inflammatory cytokines (IL-1alpha, IL-1beta, IL-6, Il-8, TNF-alpha) in the aqueous humor and POAG TM cells of glaucoma-induced rats. myricetin 0-9 interleukin 1 beta Rattus norvegicus 120-128 30405207-7 2018 VPA lowered CCI-induced inflammatory proteins (pNFkappaB, iNOS and COX-2), pro-apoptotic proteins (pAKT/AKT and pGSK-3beta/GSK-3beta), proinflammatory cytokines (TNF-alpha and IL-1beta) and nuclear pNFkappaB activation in the SN, DRG and SC in CCI rats. CCI 12-15 interleukin 1 beta Rattus norvegicus 176-184 30450033-10 2018 The lactulose pretreatment significantly repressed over-expressions of proteins of TLR4, MyD88, TRAF6, NFkappaB, IL-1beta, IL-6, TNF-alpha, cleaved caspase 3, PARP-1. Lactulose 4-13 interleukin 1 beta Rattus norvegicus 113-121 30118883-7 2018 RESULTS: Atorvastatin and alcohol induced liver inflammation with increasing the expression of NLRP3, IL-1beta and caspase-8 immune-reaction. Atorvastatin 9-21 interleukin 1 beta Rattus norvegicus 102-110 30103115-0 2018 Caffeic acid protects against IL-1beta-induced inflammatory responses and cartilage degradation in articular chondrocytes. caffeic acid 0-12 interleukin 1 beta Rattus norvegicus 30-38 30118883-7 2018 RESULTS: Atorvastatin and alcohol induced liver inflammation with increasing the expression of NLRP3, IL-1beta and caspase-8 immune-reaction. Alcohols 26-33 interleukin 1 beta Rattus norvegicus 102-110 30067070-0 2018 Acetazolamide protects rat articular chondrocytes from IL-1beta-induced apoptosis by inhibiting the activation of NF-kappaB signal pathway. Acetazolamide 0-13 interleukin 1 beta Rattus norvegicus 55-63 29969574-13 2018 Aspirin also obviously downregulated the mRNA expressions of IL-6, IL-1beta, and MCP-1 and assuaged the activation of TLR4, MyD88, NF-kappaBp65, and TLR2 in the placental tissue. Aspirin 0-7 interleukin 1 beta Rattus norvegicus 67-75 30067070-4 2018 Here, we investigated the antiapoptotic effect of AZ on interleukin-1beta (IL-1beta)-induced apoptosis, a classic in vitro model of chondrocyte apoptosis. Acetazolamide 50-52 interleukin 1 beta Rattus norvegicus 56-73 30067070-4 2018 Here, we investigated the antiapoptotic effect of AZ on interleukin-1beta (IL-1beta)-induced apoptosis, a classic in vitro model of chondrocyte apoptosis. Acetazolamide 50-52 interleukin 1 beta Rattus norvegicus 75-83 30067070-5 2018 AZ treatment could inhibit IL-1beta-induced apoptosis, evidenced by increasing cell viability, relieving apoptotic nuclear morphology, decreasing apoptosis rates, and restoring mitochondrial membrane potential. Acetazolamide 0-2 interleukin 1 beta Rattus norvegicus 27-35 30067070-7 2018 In conclusion, our findings indicated that AZ could effectively attenuate IL-1beta-induced chondrocyte apoptosis mediated by regulating the protein levels of apoptosis-related genes and inhibiting the activation of NF-kappaB signal pathway, suggesting that AZ might be of potential clinical interest in RA treatment. Acetazolamide 43-45 interleukin 1 beta Rattus norvegicus 74-82 29457525-8 2018 In in vitro tests, both apoptosis and phosphorylated ERK expression in rat AFCs decreased in the IL-1beta+U0126 group compared with the IL-1beta group. U 0126 106-111 interleukin 1 beta Rattus norvegicus 97-105 30090976-17 2018 FF extract and tussilagone significantly inhibited LPS-induced expression of TNF-alpha, IL-1beta, and IL-6 mRNA, and also suppressed the phosphorylation of ERK1/2, JNK and p38 MAPK and the nuclear expression of NF-kappaB in a dose-dependent manner. phenylalanylphenylalanine 0-2 interleukin 1 beta Rattus norvegicus 88-96 30090976-17 2018 FF extract and tussilagone significantly inhibited LPS-induced expression of TNF-alpha, IL-1beta, and IL-6 mRNA, and also suppressed the phosphorylation of ERK1/2, JNK and p38 MAPK and the nuclear expression of NF-kappaB in a dose-dependent manner. tussilagone 15-26 interleukin 1 beta Rattus norvegicus 88-96 29457525-8 2018 In in vitro tests, both apoptosis and phosphorylated ERK expression in rat AFCs decreased in the IL-1beta+U0126 group compared with the IL-1beta group. U 0126 106-111 interleukin 1 beta Rattus norvegicus 136-144 30195108-8 2018 Finally, administration of BA significantly decreased CUMS-induced apoptosis and inflammatory cytokines (caspase-1 and IL-1beta) in hippocampus. baicalin 27-29 interleukin 1 beta Rattus norvegicus 119-127 30218953-7 2018 The results showed that BR notably inhibited the productions of TNF-alpha, pro-IL-1beta, PGE2 and NO, and suppressed the NF-kappaB signaling pathway in LPS-stimulated macrophages. Bromine 24-26 interleukin 1 beta Rattus norvegicus 79-87 30218953-9 2018 BR treatment also increased the levels of TGF-beta and IL-4, decreased the contents of IL-1beta and IL-18, and elevated the levels of CAT, GSH and SOD in the colons. Bromine 0-2 interleukin 1 beta Rattus norvegicus 87-95 31949616-13 2018 Moreover, DiNAC strongly reduced the generation of inflammatory cytokines, such as interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta), through NF-kappaB downregulation. N,N-diacetylcystine 10-15 interleukin 1 beta Rattus norvegicus 149-166 31949616-13 2018 Moreover, DiNAC strongly reduced the generation of inflammatory cytokines, such as interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta), through NF-kappaB downregulation. N,N-diacetylcystine 10-15 interleukin 1 beta Rattus norvegicus 168-176 29761884-7 2018 In vitro studies revealed that TBMS I suppressed the production of pro-inflammatory cytokines including IL-1beta, IL-6, IL-8 and TNFalpha, and downregulated the expression of MMP-9. Tobramycin 31-35 interleukin 1 beta Rattus norvegicus 104-112 29731490-5 2018 Sulfasalazine reduced the increased IL-1beta, IL-6, TNF-alpha and PGE2 levels and significantly increased anti-inflammatory cytokine IL-10 levels. Sulfasalazine 0-13 interleukin 1 beta Rattus norvegicus 36-44 30243066-0 2018 Pravastatin alleviates interleukin 1beta-induced cartilage degradation by restoring impaired autophagy associated with MAPK pathway inhibition. Pravastatin 0-11 interleukin 1 beta Rattus norvegicus 23-40 30243066-6 2018 Activation of MAPK, PI3K/Akt, and NF-kappaB pathways in chondrocytes with or without pravastatin treatment during IL-1beta stimulation was examined by Western blotting. Pravastatin 85-96 interleukin 1 beta Rattus norvegicus 114-122 30243066-7 2018 RESULTS: Our results showed that pravastatin downregulated the degradation related genes MMP3, MMP13 and ADAMTS5, as well as extracellular matrix degeneration induced by IL-1beta. Pravastatin 33-44 interleukin 1 beta Rattus norvegicus 170-178 30243066-8 2018 In addition, pravastatin upregulated the autophagy related genes atg7, atg12, Beclin1, and LC3 II in IL-1beta stimulated chondrocytes. Pravastatin 13-24 interleukin 1 beta Rattus norvegicus 101-109 30139671-10 2018 Baicalein significantly inhibited the expression of tumour necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and IL-1beta on days 14 and 28, and attenuated the activation of astrocytes in the L4-5 spinal cord less than day 28 after PST. baicalein 0-9 interleukin 1 beta Rattus norvegicus 120-128 30381729-7 2018 The methanol extract of H. sabdariffa improved spatial memory consolidation in Wistar rats and prevented impairment in spatial memory consolidation by maintaining the ratio of IL-1beta/IL-1ra in the plasma and hippocampus of Wistar rats who experienced overtraining. Methanol 4-12 interleukin 1 beta Rattus norvegicus 176-184 30221694-4 2018 Administration of fasudil led to reductions in polymorphonuclear neutrophil counts, and the protein concentrations of tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 in the bronchoalveolar lavage fluid of rats with sepsis-induced ALI. fasudil 18-25 interleukin 1 beta Rattus norvegicus 147-169 30062553-8 2018 Quercetin also significantly decreased the levels of inflammatory markers (cyclooxygenase-2, interleukin-1beta, and tumor necrosis factor alpha) in diabetic brains. Quercetin 0-9 interleukin 1 beta Rattus norvegicus 93-110 30066023-12 2018 GLB treatment significantly downregulated the expressions of TGF-beta1, alpha-SMA, NLRP3, ASC, caspase-1, and IL-1beta, and upregulated MMP-2 and catalase against TAA-induced liver damage. Glyburide 0-3 interleukin 1 beta Rattus norvegicus 110-118 29959433-15 2018 While metformin led to weight loss, both metformin and minocycline significantly decreased neuroinflammation in the assessment of cord tissue histopathology, and levels of TNF-alpha and interleukin-1beta (p < 0.001). Metformin 41-50 interleukin 1 beta Rattus norvegicus 186-203 30379218-11 2018 Serum IL-1b was lower in 5-FU/SAL group (134.5+-23pg/ml) than in 5-FU/SIMV (48.3+-9pg/ml). Fluorouracil 25-29 interleukin 1 beta Rattus norvegicus 6-11 30379218-11 2018 Serum IL-1b was lower in 5-FU/SAL group (134.5+-23pg/ml) than in 5-FU/SIMV (48.3+-9pg/ml). sal 30-33 interleukin 1 beta Rattus norvegicus 6-11 30176319-10 2018 Moreover, Eti-Zn treatment reduced both the over-activation of microglia and the expressions of neuroinflammatory cytokines (TNF-alpha, IL-1beta and IL-6) in the hippocampus. eti-zn 10-16 interleukin 1 beta Rattus norvegicus 136-144 30152849-8 2018 Pretreatment of the rat NR8383 macrophage cell line with SB203580 significantly decreased the population of caspase-1+PI+ pyroptotic cells and expression of NLRP3/IL-1beta. SB 203580 57-65 interleukin 1 beta Rattus norvegicus 163-171 30311182-9 2018 Compared with 6-OHDA treats rats, aVNS treatment significantly improved motor deficits, increased TH and alpha7 nAChR expression, and reduced the levels of inflammatory cytokines (tumor necrosis factor-a (TNF-alpha) and interleukin-1beta (IL-1beta)) (p < 0.05). avns 34-38 interleukin 1 beta Rattus norvegicus 220-237 30510620-9 2018 In addition, especially high dose of propofol postconditioning reduced TNF-alpha, IL-1beta, IL-6, TLR4, and NF-kappaB inflammatory pathway, accompanied with decrease of neutrophil elastase activity, MPO activity, 8-isoprotane, p47phox and gp91phox protein expressions, and increase of SOD activity. Propofol 37-45 interleukin 1 beta Rattus norvegicus 82-90 30194012-6 2018 Following the administration of atorvastatin, release of pro-inflammatory (IL-1beta, IL-6 and IL-8) and anti-inflammatory (TGF-beta1 and TGF-beta2) cytokines was found to decrease, with a significant alveolar bone healing, when compared to that of control. Atorvastatin 32-44 interleukin 1 beta Rattus norvegicus 75-83 30365261-10 2018 The effects of EA-GV 20+HT 7+SP 6 were evidently superior to those of EA-GV 20 and EA-SP 6 in up-regulating serum IL-1 beta, BDNF and PGD2levels, and to those of HT 7, GV 20 and SP 6 in up-regulating serum MLT level, and significantly superior to those of EA-ST 7 and EA-SP 6 in down-regulating serum CORT (P<0.05). ea-gv 15-20 interleukin 1 beta Rattus norvegicus 114-123 30365261-10 2018 The effects of EA-GV 20+HT 7+SP 6 were evidently superior to those of EA-GV 20 and EA-SP 6 in up-regulating serum IL-1 beta, BDNF and PGD2levels, and to those of HT 7, GV 20 and SP 6 in up-regulating serum MLT level, and significantly superior to those of EA-ST 7 and EA-SP 6 in down-regulating serum CORT (P<0.05). ea-gv 20 15-23 interleukin 1 beta Rattus norvegicus 114-123 30365261-10 2018 The effects of EA-GV 20+HT 7+SP 6 were evidently superior to those of EA-GV 20 and EA-SP 6 in up-regulating serum IL-1 beta, BDNF and PGD2levels, and to those of HT 7, GV 20 and SP 6 in up-regulating serum MLT level, and significantly superior to those of EA-ST 7 and EA-SP 6 in down-regulating serum CORT (P<0.05). glycylvaline 18-20 interleukin 1 beta Rattus norvegicus 114-123 30405406-4 2018 In the present study, Pue effectively ameliorated pathological injury of the liver, decreased serum enzyme (ALT, AST, gamma-GT, AKP, DBIL, and TBIL) levels, regulated the balance between pro-inflammatory (TNF-alpha, IL-1beta, IL-4, IL-6, and TGF-beta1) and anti-inflammatory cytokines (IL-10), restored the cell cycle and inhibited hepatocellular apoptosis and caspase-3 expression in rats with liver injury induced by 2-AAF/PH. puerarin 22-25 interleukin 1 beta Rattus norvegicus 216-224 30296789-8 2018 Additionally, OA-induced expression of TNF-alpha and IL-1beta were suppressed by alprostadil. Alprostadil 81-92 interleukin 1 beta Rattus norvegicus 53-61 30349478-9 2018 Immunofluorescence and western blot analysis provided evidence that pioglitazone mediates both anti-inflammatory and anti-oxidant effects by decreasing NF-kappaB and IL-1beta expression in the cochlea and opposing the oxidative damage induced by noise insult. Pioglitazone 68-80 interleukin 1 beta Rattus norvegicus 166-174 30333751-8 2018 Further, MG decreased spinal and muscle interleukin-1beta concentration and restored muscle redox status. mangiferin 9-11 interleukin 1 beta Rattus norvegicus 40-57 29920358-11 2018 Furthermore, the overproduction of PGE2, COX-2, IL-1beta, IL-6, NF-kB and TNF-alpha were remarkably attenuated in all EG treated rats, however, IL-4 and 10 were markedly increased. eg 118-120 interleukin 1 beta Rattus norvegicus 48-56 30291731-3 2018 Western blot and immunohistochemical analyses showed that expression of NLRP3, caspase-1 and interleukin-1beta was upregulated significantly in a dose-dependent manner after cisplatin exposure. Cisplatin 174-183 interleukin 1 beta Rattus norvegicus 93-110 30195730-11 2018 Rifampicin pretreatment attenuated SE-induced neuroinflammation and decreased the hippocampal expression of interleukin-1beta, tumor necrosis factor-alpha, nuclear factor kappa-B, and cyclooxygenase-2. Rifampin 0-10 interleukin 1 beta Rattus norvegicus 108-178 28914439-8 2018 RESULTS: Compared with DMBA, DMBA plus DH significantly increased the average number of tumors, average tumor weight, levels of serum MMP-9, TIMP-1, TNF-alpha and IL-1beta, and contents of tumor tissue TNF-alpha and IL-1beta (P<0.05 or P<0.01). 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole 39-41 interleukin 1 beta Rattus norvegicus 163-171 30515034-3 2018 We aimed to investigate the anti-inflammatory effects of PGB on carrageenan (CAR)-induced paw edema and its effects on tumor necrosis factor-alpha (TNF-alpha) and interleukine-1beta (IL-1beta) acting as acute phase cytokines in inflammation, and anti-inflammatory cytokine IL-10, in rats. Pregabalin 57-60 interleukin 1 beta Rattus norvegicus 183-191 30515034-11 2018 The TNF-alpha and IL-1beta levels in the PGB and INDO groups were comparable to the control group, whereas in the CAR group, these levels were increased. Pregabalin 41-44 interleukin 1 beta Rattus norvegicus 18-26 30515034-11 2018 The TNF-alpha and IL-1beta levels in the PGB and INDO groups were comparable to the control group, whereas in the CAR group, these levels were increased. Indomethacin 49-53 interleukin 1 beta Rattus norvegicus 18-26 30119269-8 2018 Liquiritigenin suppressed HG-induced inflammatory response, as demonstrated by the reduced expressions and secretion of interleukin (IL)-6 and IL-1beta in HBZY-1 cells. liquiritigenin 0-14 interleukin 1 beta Rattus norvegicus 143-151 28914439-8 2018 RESULTS: Compared with DMBA, DMBA plus DH significantly increased the average number of tumors, average tumor weight, levels of serum MMP-9, TIMP-1, TNF-alpha and IL-1beta, and contents of tumor tissue TNF-alpha and IL-1beta (P<0.05 or P<0.01). 9,10-Dimethyl-1,2-benzanthracene 29-33 interleukin 1 beta Rattus norvegicus 163-171 28914439-8 2018 RESULTS: Compared with DMBA, DMBA plus DH significantly increased the average number of tumors, average tumor weight, levels of serum MMP-9, TIMP-1, TNF-alpha and IL-1beta, and contents of tumor tissue TNF-alpha and IL-1beta (P<0.05 or P<0.01). 9,10-Dimethyl-1,2-benzanthracene 29-33 interleukin 1 beta Rattus norvegicus 216-224 28914439-8 2018 RESULTS: Compared with DMBA, DMBA plus DH significantly increased the average number of tumors, average tumor weight, levels of serum MMP-9, TIMP-1, TNF-alpha and IL-1beta, and contents of tumor tissue TNF-alpha and IL-1beta (P<0.05 or P<0.01). 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole 39-41 interleukin 1 beta Rattus norvegicus 216-224 28914439-9 2018 CONCLUSION: DH could accelerate the development of mammary tumors through increasing the expressions of MMP-9, TIMP-1, TNF-alpha and IL-1beta in DMBA-induced rats. 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole 12-14 interleukin 1 beta Rattus norvegicus 133-141 30214546-6 2018 In the group treated with resveratrol, renal injury induced by CLP was alleviated with downregulation of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and kidney injury molecule (KIM)-1 expression. Resveratrol 26-37 interleukin 1 beta Rattus norvegicus 140-162 28914439-9 2018 CONCLUSION: DH could accelerate the development of mammary tumors through increasing the expressions of MMP-9, TIMP-1, TNF-alpha and IL-1beta in DMBA-induced rats. 9,10-Dimethyl-1,2-benzanthracene 145-149 interleukin 1 beta Rattus norvegicus 133-141 30422019-10 2018 Mechanistic studies revealed that DMFO reduced proinflammatory genes (IL1beta, TNFalpha, IL6) and protein levels (COX2, MCP1), with a concurrent increase in antioxidant genes (NQO1, haem oxygenase 1 (HO-1), Glo1, Nrf2) and protein (HO-1) in LPS-stimulated macrophages. dmfo 34-38 interleukin 1 beta Rattus norvegicus 70-77 30025709-11 2018 Procyanidin B2 suppressed expression of IL-1beta and IL-18 at both RNA and protein levels, similar to the NLRP3 gene silenced rats. procyanidin B2 0-14 interleukin 1 beta Rattus norvegicus 40-48 29460078-6 2018 The LP reduced the nitric oxide and proteoglycan release from the cartilage explants under IL-1beta induction. Nitric Oxide 19-31 interleukin 1 beta Rattus norvegicus 91-99 30107238-7 2018 The results showed that treatment of rats with Rsv prevented the deficits of spatial reference memory induced by EtOH and mitigated EtOH-induced neuroinflammation by inhibiting microglial activation and decreasing the levels of inflammatory cytokines including interleukin-1beta, interleukin-6 and tumor necrosis factor alpha. Resveratrol 47-50 interleukin 1 beta Rattus norvegicus 261-278 30030129-9 2018 Compared with the HI groups, GB inhibited the activation of microglia and decreased the production of IL-1beta and IL-18 in neocortex. ginkgolide B 29-31 interleukin 1 beta Rattus norvegicus 102-110 30107367-10 2018 MCC950 (an inhibitor of NLRP3 inflammasome) and VX-765 (a Caspase-1 Inhibitor) showed significant interaction with CK on the decrease of IL-1beta concentration in HBZY-1 cells. N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide 0-6 interleukin 1 beta Rattus norvegicus 137-145 30107367-10 2018 MCC950 (an inhibitor of NLRP3 inflammasome) and VX-765 (a Caspase-1 Inhibitor) showed significant interaction with CK on the decrease of IL-1beta concentration in HBZY-1 cells. belnacasan 48-54 interleukin 1 beta Rattus norvegicus 137-145 30107367-10 2018 MCC950 (an inhibitor of NLRP3 inflammasome) and VX-765 (a Caspase-1 Inhibitor) showed significant interaction with CK on the decrease of IL-1beta concentration in HBZY-1 cells. ginsenoside M1 115-117 interleukin 1 beta Rattus norvegicus 137-145 30119032-8 2018 Polygalacic acid significantly reduced the expression of MMPs and COX-2, which could be induced by IL-1beta in rat chondrocytes. polygalacic acid 0-16 interleukin 1 beta Rattus norvegicus 99-107 30119032-10 2018 To investigate the underlying mechanism, we found that polygalacic acid suppressed both the IL-1beta-induced activation of Wnt/beta-catenin and the mitogen-activated protein kinase (MAPK) signal pathway in chondrocytes. polygalacic acid 55-71 interleukin 1 beta Rattus norvegicus 92-100 30393431-7 2018 EEBGP administration did not significantly change the mRNA expression levels of antioxidant enzyme genes in the liver of APAP-treated rats but decreased the mRNA expression of cytokines including Il10 and Il1b, with a significant difference in Il10 expression. eebgp 0-5 interleukin 1 beta Rattus norvegicus 205-209 30372737-10 2018 Diquafosol increased the levels of phospho-Erk1/2, phospho-90RSK, phospho-Akt, and IkappaB-alpha, whereas it significantly decreased the levels of NF-kappaB-p65, IL-1beta, and TNF-alpha. diquafosol 0-10 interleukin 1 beta Rattus norvegicus 162-170 30214546-8 2018 Of note, knockdown of Nrf2 effectively abrogated the downregulation of TNF-alpha, IL-1beta and KIM-1 expression induced by resveratrol in vitro. Resveratrol 123-134 interleukin 1 beta Rattus norvegicus 82-90 30106807-8 2018 Optic nerve tissue IL-1beta levels were significantly lower in group III than in group II (P < 0.05) and higher than in group I (P < 0.05).Mannitol increased the antioxidant GPx levels and decreased the IL-1beta levels, which can protect the optic nerve from secondary injury after severe acute trauma. Mannitol 145-153 interleukin 1 beta Rattus norvegicus 19-27 30106807-8 2018 Optic nerve tissue IL-1beta levels were significantly lower in group III than in group II (P < 0.05) and higher than in group I (P < 0.05).Mannitol increased the antioxidant GPx levels and decreased the IL-1beta levels, which can protect the optic nerve from secondary injury after severe acute trauma. Mannitol 145-153 interleukin 1 beta Rattus norvegicus 209-217 30262747-8 2018 Treatment with minocycline significantly attenuated LPS-induced allodynia, hyperalgesia, the increase in spinal cord microglia, and astrocyte activation, and elevated levels of IL-1beta, COX-2, and PGE2 in neonatal rats. Minocycline 15-26 interleukin 1 beta Rattus norvegicus 177-185 30262747-9 2018 These results suggest that minocycline provides protection against neonatal systemic LPS exposure-induced enhanced pain sensitivity (allodynia and hyperalgesia), and that the protective effects may be associated with its ability to attenuate LPS-induced microglia activation, and the levels of IL-1beta, COX-2, and PGE2 in the spinal cord of neonatal rats. Minocycline 27-38 interleukin 1 beta Rattus norvegicus 294-302 29928887-6 2018 Although no significant molecular differences could be observed within the IoN parenchyma between LPS and Vhcl-pretreated animals, a significant increase of key inflammatory cytokine Interleukin 1 beta (IL - 1beta) could be found in the TG of LPS-pretreated CCI-injured animals versus controls. vhcl 106-110 interleukin 1 beta Rattus norvegicus 203-213 29928887-6 2018 Although no significant molecular differences could be observed within the IoN parenchyma between LPS and Vhcl-pretreated animals, a significant increase of key inflammatory cytokine Interleukin 1 beta (IL - 1beta) could be found in the TG of LPS-pretreated CCI-injured animals versus controls. CCI 258-261 interleukin 1 beta Rattus norvegicus 203-213 29552688-7 2018 In addition, TNF-alpha and IL-1beta plasma levels were significantly lower in the control and 5-FU+melatonin groups than in the 5-FU group. Fluorouracil 94-98 interleukin 1 beta Rattus norvegicus 27-35 29552688-7 2018 In addition, TNF-alpha and IL-1beta plasma levels were significantly lower in the control and 5-FU+melatonin groups than in the 5-FU group. Melatonin 99-108 interleukin 1 beta Rattus norvegicus 27-35 29552688-7 2018 In addition, TNF-alpha and IL-1beta plasma levels were significantly lower in the control and 5-FU+melatonin groups than in the 5-FU group. Fluorouracil 128-132 interleukin 1 beta Rattus norvegicus 27-35 30086885-9 2018 In addition, expression of inflammatory-related cytokines such as TNF-alpha and IL-1beta decreased significantly in SRP-NTP group, while IL-10 level increased substantially. srp-ntp 116-123 interleukin 1 beta Rattus norvegicus 80-88 30252871-9 2018 Histological findings and a significant drop in several markers of inflammation (p65 nuclear translocation, mRNA expressions of TNF-alpha, IL-1beta, IL-6) showed that DEX treatment reversed cholestasis-induced inflammation, and similar results have been obtained with oxidative stress markers. Dextromethorphan 167-170 interleukin 1 beta Rattus norvegicus 139-147 30076921-2 2018 Diacerein (DIA) is interleukin-1b (IL-1b) blocker which has a protective role against myocardial ischemia-reperfusion, however, to-date this role has not been investigated in testicular ischemia- reperfusion (TIR). diacerein 0-9 interleukin 1 beta Rattus norvegicus 19-33 30076921-2 2018 Diacerein (DIA) is interleukin-1b (IL-1b) blocker which has a protective role against myocardial ischemia-reperfusion, however, to-date this role has not been investigated in testicular ischemia- reperfusion (TIR). diacerein 0-9 interleukin 1 beta Rattus norvegicus 35-40 30254599-14 2018 In vitro experiments confirmed that LPD or control microglial cells exposed to ibotenate display an increased expression, at both protein and molecular levels, of A2aR and M1 markers (IL-1beta, IL-6, iNOS, TNFalpha). Ibotenic Acid 79-88 interleukin 1 beta Rattus norvegicus 184-192 30254425-8 2018 Additionally, the expression of IL-1beta, IL-6, monocyte chemotactic protein-1, macrophage inflammatory protein-1alpha and TGF-beta were significantly decreased by tacrolimus. Tacrolimus 164-174 interleukin 1 beta Rattus norvegicus 32-40 30189852-5 2018 Treatment of hippocampal neurons with EPA also ameliorated the decrease in Akt and CREB phosphorylation induced by IL-1beta and BDNF down-regulation mediated by IL-1beta. Eicosapentaenoic Acid 38-41 interleukin 1 beta Rattus norvegicus 115-123 30189852-5 2018 Treatment of hippocampal neurons with EPA also ameliorated the decrease in Akt and CREB phosphorylation induced by IL-1beta and BDNF down-regulation mediated by IL-1beta. Eicosapentaenoic Acid 38-41 interleukin 1 beta Rattus norvegicus 161-169 30189852-0 2018 Involvement of Akt/CREB signaling pathways in the protective effect of EPA against interleukin-1beta-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons. Eicosapentaenoic Acid 71-74 interleukin 1 beta Rattus norvegicus 83-100 30189852-7 2018 CONCLUSIONS: Our data indicate that EPA elicited neuroprotection toward IL-1beta-induced cell damage and BDNF decrease and that its effects potentially occurred via the Akt/CREB signaling pathway. Eicosapentaenoic Acid 36-39 interleukin 1 beta Rattus norvegicus 72-80 30189852-1 2018 BACKGROUND: Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1beta (IL-1beta), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. omega-3 polyunsaturated fatty acid 55-89 interleukin 1 beta Rattus norvegicus 188-205 30220159-1 2018 Objective: In order to study the diagnosis and treatment value of chelating anti-IL-1beta mAb-SPIONs in temporal lobe epilepsy model induced by lithium chlorid and pilocarpine. Lithium Chloride 144-159 interleukin 1 beta Rattus norvegicus 81-89 30189852-1 2018 BACKGROUND: Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1beta (IL-1beta), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. omega-3 polyunsaturated fatty acid 55-89 interleukin 1 beta Rattus norvegicus 207-215 30189852-1 2018 BACKGROUND: Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1beta (IL-1beta), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. Eicosapentaenoic Acid 90-111 interleukin 1 beta Rattus norvegicus 188-205 30189852-1 2018 BACKGROUND: Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1beta (IL-1beta), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. Eicosapentaenoic Acid 90-111 interleukin 1 beta Rattus norvegicus 207-215 30189852-1 2018 BACKGROUND: Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1beta (IL-1beta), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. Eicosapentaenoic Acid 113-116 interleukin 1 beta Rattus norvegicus 188-205 30189852-1 2018 BACKGROUND: Our published data have indicated that the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) provides beneficial effects by attenuating neuronal damage induced by interleukin-1beta (IL-1beta), and up-regulation of the expression of brain-derived neurotrophic factor (BDNF) represents a crucial part in the neuroprotective effect of EPA. Eicosapentaenoic Acid 113-116 interleukin 1 beta Rattus norvegicus 207-215 30220159-1 2018 Objective: In order to study the diagnosis and treatment value of chelating anti-IL-1beta mAb-SPIONs in temporal lobe epilepsy model induced by lithium chlorid and pilocarpine. Pilocarpine 164-175 interleukin 1 beta Rattus norvegicus 81-89 29722563-10 2018 HS/CR increased serum LPS, HA, HMGB1, and some cytokines [interleukin (IL)-1alpha, IL-1beta, IL-6, and interferon-gamma]. Chromium 3-5 interleukin 1 beta Rattus norvegicus 83-91 30373863-1 2018 OBJECTIVE: The aim of the present study was to explore the role of catechin on the expression of heat shock protein 27 (HSP27), nuclear factor-kappa beta (NF-kappaB) and inflammatory factors IL-1beta, IL-6 and TNF-alpha in streptozotocin (STZ)-induced diabetic retinopathy (DR) rats. Catechin 67-75 interleukin 1 beta Rattus norvegicus 191-199 30152807-6 2018 RESULTS: CP group administered cisplatin had significantly increased blood, serum, and cardiac tissue malondialdehyde (MDA), interleukin 1 beta (IL-1ss), tumor necrosis factor alpha (TNF-alpha), troponin I, creatine kinase (CK), and CK-MB levels compared to the HE group, whereas there was a significant decrease in the total glutathione (tGSH) levels. Cisplatin 31-40 interleukin 1 beta Rattus norvegicus 125-143 29527628-9 2018 PGE2 and cytokines IL-1beta, IL-10, and TNF-alpha showed significant increase in DNP compared with control group. 2,4-Dinitrophenol 81-84 interleukin 1 beta Rattus norvegicus 19-27 30021385-18 2018 Furthermore, renal structural abnormalities and the elevation of TNF-alpha, MCP-1 and IL-1beta expression level were blocked by the administration of UA. ursolic acid 150-152 interleukin 1 beta Rattus norvegicus 86-94 30118750-7 2018 Osthole treatment decreased the co-expression levels of P2X4 and glial fibrillary acidic protein (GFAP) and reduced the up-regulated expression of interleukin-1 beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha), brain-derived neurotrophic factor (BDNF) and phosphorylated-p38MAPK and enhanced the down-regulation of IL-10 in DM rats. osthol 0-7 interleukin 1 beta Rattus norvegicus 147-165 30118750-7 2018 Osthole treatment decreased the co-expression levels of P2X4 and glial fibrillary acidic protein (GFAP) and reduced the up-regulated expression of interleukin-1 beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha), brain-derived neurotrophic factor (BDNF) and phosphorylated-p38MAPK and enhanced the down-regulation of IL-10 in DM rats. osthol 0-7 interleukin 1 beta Rattus norvegicus 167-175 29874111-9 2018 Our results also showed that captopril treatment leads to a decrease of cyclooxygenase 2, interleukin-1beta, and beta-arrestin2 and a significant increase of AP2 gene expression levels. Captopril 29-38 interleukin 1 beta Rattus norvegicus 90-107 30039470-14 2018 Prdx6 and Nrf2 were increased, while the inflammatory cytokines including IL-1beta, TNF-alpha and IFN-gamma were decreased in ICP + MgSO4 group compared with that in ICP group. Magnesium Sulfate 132-137 interleukin 1 beta Rattus norvegicus 74-82 29975111-9 2018 Our results showed that ketamine significantly decreased ALT, AST, LDH, IL-6, TNF-alpha, and IL-1beta levels and increased IL-10 level. Ketamine 24-32 interleukin 1 beta Rattus norvegicus 93-101 30373863-8 2018 Furthermore, IL-1beta, IL-6, and TNF-alpha levels were upregulated in the retinas of STZ-induced DR rats, but these changes were partially inhibited after treatment with catechin. Streptozocin 85-88 interleukin 1 beta Rattus norvegicus 13-21 30373863-8 2018 Furthermore, IL-1beta, IL-6, and TNF-alpha levels were upregulated in the retinas of STZ-induced DR rats, but these changes were partially inhibited after treatment with catechin. Catechin 170-178 interleukin 1 beta Rattus norvegicus 13-21 29455557-7 2018 Regarding these parameters, in CIS group MDA, MPO, IL1beta and TNF-alpha levels were statistically significantly increased with cisplatin administration and giving rutin concomitantly with cisplatin prevented this increase. Cisplatin 128-137 interleukin 1 beta Rattus norvegicus 51-58 29990691-0 2018 Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1beta in rats with COPD. Melatonin 0-9 interleukin 1 beta Rattus norvegicus 98-106 29990691-9 2018 The results demonstrated that melatonin prevented the development of COPD, which was attributed to the inhibition of airway inflammation by attenuating NLRP3 inflammasome and IL-1beta. Melatonin 30-39 interleukin 1 beta Rattus norvegicus 175-183 29990691-11 2018 In conclusion, these findings suggested that melatonin attenuated airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1beta in rats with COPD. Melatonin 45-54 interleukin 1 beta Rattus norvegicus 143-151 30688941-1 2018 OBJECTIVE: In this study, the effect of mesalazine was studied on TNF alpha IL-1 beta, IL-6, and C-reactive protein (CRP) levels and inflammatory changes in rat lungs with experimental peritonitis. Mesalamine 40-50 interleukin 1 beta Rattus norvegicus 76-85 30015923-0 2018 Kaempferol inhibits interleukin-1beta stimulated matrix metalloproteinases by suppressing the MAPK-associated ERK and P38 signaling pathways. kaempferol 0-10 interleukin 1 beta Rattus norvegicus 20-37 30015923-6 2018 The results revealed that Kaempferol significantly inhibited the interleukin (IL)-1beta-induced protein expression of inflammatory mediators such as inducible nitric oxide synthase and cyclo-oxygenase-2. kaempferol 26-36 interleukin 1 beta Rattus norvegicus 65-87 30015923-7 2018 In addition, the common matrix degrading enzymes [matrix metalloproteinase (MMP)-1, MMP-3, MMP-13 and a disintegrin and metalloproteinase with thrombospondin motif-5] induced by IL-1beta were also suppressed by Kaempferol, and consequently abolished the degradation of collagen II. kaempferol 211-221 interleukin 1 beta Rattus norvegicus 178-186 30181696-6 2018 Daily dosing of alone canagliflozin and omega-3 fatty acid slightly reduced elevated levels of glucose, insulin, HOMA-R and inflammatory cytokines (IL-1beta, IL-2, and TNFalpha), whereas canagliflozin and omega-3 fatty acid combination has reduced these biochemical parameters significantly when compared with diabetic group. Canagliflozin 22-35 interleukin 1 beta Rattus norvegicus 148-156 30181696-6 2018 Daily dosing of alone canagliflozin and omega-3 fatty acid slightly reduced elevated levels of glucose, insulin, HOMA-R and inflammatory cytokines (IL-1beta, IL-2, and TNFalpha), whereas canagliflozin and omega-3 fatty acid combination has reduced these biochemical parameters significantly when compared with diabetic group. Fatty Acids, Omega-3 40-58 interleukin 1 beta Rattus norvegicus 148-156 29429051-5 2018 Moreover, cilostazol revealed an anti-inflammatory activity as manifested by hampering the global controller of inflammatory signaling pathway, nuclear factor-kappa B, together with its downstream pro-inflammatory cytokines, namely tumor necrosis factor-alpha and interleukin-1 beta, via Nurr-1 upregulation and glycogen synthase kinase 3 beta GSK-3beta inhibition. Cilostazol 10-20 interleukin 1 beta Rattus norvegicus 264-282 30688941-10 2018 CONCLUSION: TNF alpha, IL-1 beta, and CRP levels and leucocyte infiltration in the lung were found to be low in rats that were administered peritoneal irrigation using mesalazine after the development of secondary peritonitis. Mesalamine 168-178 interleukin 1 beta Rattus norvegicus 23-32 30224933-13 2018 LWDH administration decreased the expression of serum levels of IL-1beta (p>0.05), while it increased VEGF (p>0.05) expression. lwdh 0-4 interleukin 1 beta Rattus norvegicus 64-72 30468342-4 2018 On the 1st, 4th, 7th and 10th day, histological changes and distribu- tion of IL-1beta-, IL-6- and TNF-alpha-positive cells were detected in the thymus by hematoxylin-eosin and immunohistochemistry staining, respectively. Hematoxylin 155-166 interleukin 1 beta Rattus norvegicus 78-86 30468342-4 2018 On the 1st, 4th, 7th and 10th day, histological changes and distribu- tion of IL-1beta-, IL-6- and TNF-alpha-positive cells were detected in the thymus by hematoxylin-eosin and immunohistochemistry staining, respectively. Eosine Yellowish-(YS) 167-172 interleukin 1 beta Rattus norvegicus 78-86 30115081-10 2018 RESULTS: Curcumin attenuated the production of IL-1beta and TNF-alpha in rat gingival fibroblasts stimulated by LPS, and inhibited the LPS-induced decrease in OPG/sRANKL ratio and NF-kappaB activation. Curcumin 9-17 interleukin 1 beta Rattus norvegicus 47-55 30317804-15 2018 Conclusion: Methylprednisolone can effectively protect the rats from phosgene-induced acute lung injury by inhibiting the expression of the NLRP3 inflammasome and reducing the release of inflammatory factors such as interleukin-1beta (IL-1beta) mediated by it. Methylprednisolone 12-30 interleukin 1 beta Rattus norvegicus 216-233 30317804-15 2018 Conclusion: Methylprednisolone can effectively protect the rats from phosgene-induced acute lung injury by inhibiting the expression of the NLRP3 inflammasome and reducing the release of inflammatory factors such as interleukin-1beta (IL-1beta) mediated by it. Methylprednisolone 12-30 interleukin 1 beta Rattus norvegicus 235-243 30114208-8 2018 RESULTS: DEX treatment attenuated ischemia reperfusion-induced increase in NLRP3, caspase-1, IL-1beta, phospho-AKT, and phospho-ERK signaling. Dexmedetomidine 9-12 interleukin 1 beta Rattus norvegicus 93-101 30056863-6 2018 KEY FINDINGS: Olopatadine, in the present work, effectively and dose-dependently enhanced the corneal healing after alkali application, with significant reduction of the corneal opacity and neovascularization scores, besides, it suppressed the augmented corneal IL-1beta, VEGF, caspase-3 levels, and nuclear NF-kappaB immunohistochemical expression, meanwhile it abrogated the corneal histopathological changes, induced by alkali application. Olopatadine Hydrochloride 14-25 interleukin 1 beta Rattus norvegicus 262-270 30087236-5 2018 Our results showed that EESS effectively blocked the generation of reactive oxygen species in IL-1beta-treated SW1353 and rat primary chondrocytes, indicating that EESS has a potent antioxidant activity. Reactive Oxygen Species 67-90 interleukin 1 beta Rattus norvegicus 94-102 30135647-8 2018 It was found that SU5402 itself evoked depressive-like behaviors, induced microglia activation, increased production of pro-inflammatory cytokines including IL-1beta, IL-6 and TNF-alpha, and decreased the expression of CX3CL1. SU 5402 18-24 interleukin 1 beta Rattus norvegicus 157-165 30087236-6 2018 EESS also attenuated IL-1beta-induced production of nitric oxide (NO) and prostaglandin E2, major inflammatory mediators in these cells, which was associated with the inhibition of inducible NO synthase and cyclooxygenase-2 expression. Nitric Oxide 52-64 interleukin 1 beta Rattus norvegicus 21-29 30087236-6 2018 EESS also attenuated IL-1beta-induced production of nitric oxide (NO) and prostaglandin E2, major inflammatory mediators in these cells, which was associated with the inhibition of inducible NO synthase and cyclooxygenase-2 expression. Dinoprostone 74-90 interleukin 1 beta Rattus norvegicus 21-29 30020400-6 2018 As compared with the blank and NC groups, the siKSR1, U0126, and siKSR1 + U0126 groups showed decreased levels of TNF-alpha, IL-6, IL-1beta, HSP47, N-ras, Raf-1, c-fos, TNF-alpha, IL-6, p38 MAPK, cleaved caspase-3, cleaved caspase-9, p53, and cell apoptosis, accompanied by an increased mRNA and protein level of Bcl-2. U 0126 54-59 interleukin 1 beta Rattus norvegicus 131-139 30020400-6 2018 As compared with the blank and NC groups, the siKSR1, U0126, and siKSR1 + U0126 groups showed decreased levels of TNF-alpha, IL-6, IL-1beta, HSP47, N-ras, Raf-1, c-fos, TNF-alpha, IL-6, p38 MAPK, cleaved caspase-3, cleaved caspase-9, p53, and cell apoptosis, accompanied by an increased mRNA and protein level of Bcl-2. U 0126 74-79 interleukin 1 beta Rattus norvegicus 131-139 29592526-9 2018 NF-kappaB inhibitor Bay 11-7082 reduced IL-1beta expression induced by Mel + CA and prevented downregulation of AQP2 in inner medullary collecting duct cell suspensions. 3-(4-methylphenylsulfonyl)-2-propenenitrile 20-31 interleukin 1 beta Rattus norvegicus 40-48 28860068-2 2018 Maintenance of this morphine-induced persistent sensitization was dependent on spinal NOD-like receptor protein 3 (NLRP3) inflammasomes-protein complexes that proteolytically activate interleukin-1beta (IL-1beta) via caspase-1. Morphine 20-28 interleukin 1 beta Rattus norvegicus 184-201 28860068-2 2018 Maintenance of this morphine-induced persistent sensitization was dependent on spinal NOD-like receptor protein 3 (NLRP3) inflammasomes-protein complexes that proteolytically activate interleukin-1beta (IL-1beta) via caspase-1. Morphine 20-28 interleukin 1 beta Rattus norvegicus 203-211 29802827-6 2018 In addition, treatment with gAcrp (0.5 and 1 mug/ml) inhibited APAP-induced activation of the inflammasome, judged by suppression of interleukin-1beta maturation, caspase-1 activation, and apoptosis-associated speck-like protein (ASC) speck formation, suggesting that protective effects of gAcrp against APAP-induced hepatocyte death is mediated via modulation of the inflammasome. gacrp 28-33 interleukin 1 beta Rattus norvegicus 133-150 30112065-0 2018 Impact of proteasome inhibitor MG-132 on expression of NF-kappaB, IL-1beta and histological remodeling after myocardial infarction. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 31-37 interleukin 1 beta Rattus norvegicus 66-74 28523372-0 2018 Dietary eicosapentaenoic acid normalizes hippocampal omega-3 and 6 polyunsaturated fatty acid profile, attenuates glial activation and regulates BDNF function in a rodent model of neuroinflammation induced by central interleukin-1beta administration. Eicosapentaenoic Acid 8-29 interleukin 1 beta Rattus norvegicus 217-234 28523372-10 2018 IL-1beta also lowered n-3 EPA and docosapentaenoic acid concentrations but increased n-6 PUFAs and cPLA2 activity in the hippocampus. n-3 epa 22-29 interleukin 1 beta Rattus norvegicus 0-8 28523372-10 2018 IL-1beta also lowered n-3 EPA and docosapentaenoic acid concentrations but increased n-6 PUFAs and cPLA2 activity in the hippocampus. docosapentaenoic acid 34-55 interleukin 1 beta Rattus norvegicus 0-8 28523372-10 2018 IL-1beta also lowered n-3 EPA and docosapentaenoic acid concentrations but increased n-6 PUFAs and cPLA2 activity in the hippocampus. n-6 pufas 85-94 interleukin 1 beta Rattus norvegicus 0-8 29804245-7 2018 In addition, the levels of TNF-alpha and IL-1beta in Se pretreatment groups were significantly lower than that in PM2.5 exposure group. Selenium 53-55 interleukin 1 beta Rattus norvegicus 41-49 30112065-6 2018 In conclusion, MG-132 was demonstrated to improve post-MI tissue remodeling, and the mechanism may be associated with the inhibition of NF-kappaB activation and the downregulation of inflammatory cytokines, such as IL-1beta. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 15-21 interleukin 1 beta Rattus norvegicus 215-223 29660457-9 2018 In conclusion, the results demonstrate that administration of CcL has a potential antinociceptive and anti-inflammatory effect, with a mechanism that is partially dependent on TNF-alpha, IL-1beta, COX-2 and ICAM-1 inhibition and independently from the cannabinoide and opioid system and NO/cGMP/PKG/K+ATP channel pathway. Cefaclor 62-65 interleukin 1 beta Rattus norvegicus 187-195 30116400-0 2018 Paeoniflorin inhibits IL-1beta-induced MMP secretion via the NF-kappaB pathway in chondrocytes. peoniflorin 0-12 interleukin 1 beta Rattus norvegicus 22-30 30116400-7 2018 The results demonstrated that paeoniflorin was able to downregulate the expression of MMP and increase the expression of TIMP-1ntmRNA and protein in IL-1beta-induced rat chondrocytes. peoniflorin 30-42 interleukin 1 beta Rattus norvegicus 149-157 29656315-9 2018 Moreover, acamprosate also significantly suppressed the production of TNF-alpha, IL-1beta, and IL-6 in serum, which is elevated by AIA induction. Acamprosate 10-21 interleukin 1 beta Rattus norvegicus 81-89 29767261-9 2018 TNF-alpha, IL-1beta, IL-6 and MDA were decreased; SOD, GSH and catalase levels inhibited TNF-alpha, IL-1beta, IL-6 and MDA levels, and increased SOD, GSH and catalase levels in myocardial I/R rats treated with oleuropein. Glutathione 55-58 interleukin 1 beta Rattus norvegicus 100-108 30111205-13 2018 While the TNF-alpha and IL-1beta secretions significantly up-regulated in H2O2 model group compared to the Control group (p < .05). Hydrogen Peroxide 74-78 interleukin 1 beta Rattus norvegicus 24-32 30111205-15 2018 The NF-kappaB mRNA and protein levels were significantly decreased, TNF-alpha and IL-1beta secretions were significantly decreased in the Ketamine group compared with the model group (p < .05). Ketamine 138-146 interleukin 1 beta Rattus norvegicus 82-90 30111205-16 2018 CONCLUSIONS: Ketamine delays the progression of oxidative and damaged cataract by regulating HMGB-1/NF-kappaB expression, inhibiting TNF-alpha, IL-1beta, and apoptosis, and promoting cell proliferation. Ketamine 13-21 interleukin 1 beta Rattus norvegicus 144-152 30110204-8 2018 The effects of YH23537 on mRNA levels in chondrocytes stimulated with interleukin (IL)-1beta were analyzed using random polymerase chain reaction. yh23537 15-22 interleukin 1 beta Rattus norvegicus 70-92 31949803-10 2018 The expressions of IL-1beta, TGF beta and TNF alpha were up-regulated in the colons of IBS rats and were down-regulated with the intervention of the activator of AMP (P<0.05). Adenosine Monophosphate 162-165 interleukin 1 beta Rattus norvegicus 19-27 29603293-4 2018 Treatment of RIN-m5F cells with sciadopitysin prevented MG-induced production of interleukin-1beta, intracellular reactive oxygen species and cardiolipin peroxidation. sciadopitysin 32-45 interleukin 1 beta Rattus norvegicus 81-98 29603293-4 2018 Treatment of RIN-m5F cells with sciadopitysin prevented MG-induced production of interleukin-1beta, intracellular reactive oxygen species and cardiolipin peroxidation. Pyruvaldehyde 56-58 interleukin 1 beta Rattus norvegicus 81-98 29857242-7 2018 Additionally, beta-carotene decreased the generation of pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin-1beta, interleukin-18 and cyclooxygenase-2, and inhibited the activation of astrocyte in the spinal cord. beta Carotene 14-27 interleukin 1 beta Rattus norvegicus 123-140 30110204-12 2018 YH23537 suppressed the expression of metalloproteinase-3, nitrotyrosine, IL-1beta and IL-6 increased in OA joints. yh23537 0-7 interleukin 1 beta Rattus norvegicus 73-81 29557530-9 2018 Results indicated that Cd increased levels of the oxidative biomarkers (MDA, NO, GSSG and 8-OHdG) and the inflammatory mediators (TNF-alpha and IL-1beta), while lowered GSH, SOD, CAT, GPx and ATP levels. Cadmium 23-25 interleukin 1 beta Rattus norvegicus 144-152 29884910-8 2018 Treatment with glyburide significantly mitigated the CPB-increased ASC, caspase-1 p10 and IL-1beta expression, and the percentages of AM pyroptosis in the lungs, as well as the levels of HMGB1 in serum and BALF in rats. Glyburide 15-24 interleukin 1 beta Rattus norvegicus 90-98 29901140-10 2018 Therefore, the present results determined that high glucose-induced activation of the NLRP3 inflammasome is mediated by Syk/JNK activation, which subsequently increased the protein expression level of IL-1beta and mature IL-1beta. Glucose 52-59 interleukin 1 beta Rattus norvegicus 201-209 29901140-10 2018 Therefore, the present results determined that high glucose-induced activation of the NLRP3 inflammasome is mediated by Syk/JNK activation, which subsequently increased the protein expression level of IL-1beta and mature IL-1beta. Glucose 52-59 interleukin 1 beta Rattus norvegicus 221-229 30166095-13 2018 Finally, we demonstrated that the extract restored the scopolamine-decreased BDNF expression and increased IL1beta expression in the rat hippocampus. Scopolamine 55-66 interleukin 1 beta Rattus norvegicus 107-114 29683870-8 2018 The results indicated that STVNa (20 mg/kg) showed significant neuroprotective effects 3 and 7 days after TBI, including the reduction of cortical lesions, improvement of the neurological severity score, significantly increased number of restored neurons, decreased number of astrocytes, and lower concentrations of tumor necrosis factor-alpha and interleukin-1beta. stvna 27-32 interleukin 1 beta Rattus norvegicus 348-365 29727961-3 2018 Similarly, lambda-cyhalothrin (4 and 8mg/kg bw, for 6days), in a dose-dependent manner, increased significantly hepatic CYP1A1, 1A2, 2A1, 2B1, 2B2, 2E1, 3A1, 3A2 and 4A1 mRNA levels and IL-1beta, NFkappaB, Nrf2, p53, caspase-3 and Bax gene expressions. cyhalothrin 18-29 interleukin 1 beta Rattus norvegicus 186-194 29580890-0 2018 Mifepristone attenuates depression-like changes induced by chronic central administration of interleukin-1beta in rats. Mifepristone 0-12 interleukin 1 beta Rattus norvegicus 93-110 29580890-1 2018 Increased proinflammatory cytokines, such as interleukin (IL)-1beta, may play an important role in the etiology of depression because they cause the hypothalamic-pituitary-adrenal axis to release glucocorticoids (GC) and induce dysfunction of serotonin and norepinephrine neurotransmission. Serotonin 243-252 interleukin 1 beta Rattus norvegicus 45-67 29580890-1 2018 Increased proinflammatory cytokines, such as interleukin (IL)-1beta, may play an important role in the etiology of depression because they cause the hypothalamic-pituitary-adrenal axis to release glucocorticoids (GC) and induce dysfunction of serotonin and norepinephrine neurotransmission. Norepinephrine 257-271 interleukin 1 beta Rattus norvegicus 45-67 29580890-3 2018 Here, we tested the hypothesis that glucocorticoid receptor (GR) antagonist mifepristone (RU486) may attenuate IL-1beta-induced depression-like behavior by regulating the neuroinflammation and neurotrophin functions of microglia and astrocytes. Mifepristone 76-88 interleukin 1 beta Rattus norvegicus 111-119 29580890-3 2018 Here, we tested the hypothesis that glucocorticoid receptor (GR) antagonist mifepristone (RU486) may attenuate IL-1beta-induced depression-like behavior by regulating the neuroinflammation and neurotrophin functions of microglia and astrocytes. Mifepristone 90-95 interleukin 1 beta Rattus norvegicus 111-119 29580890-8 2018 RU486 treatment markedly attenuated these changes induced by IL-1beta, except for the expressions of GFR-alpha1. Mifepristone 0-5 interleukin 1 beta Rattus norvegicus 61-69 29654614-6 2018 Quercetin was identified to ameliorate the histo-pathologic changes, decrease the expression of pro-inflammatory cytokines IL-1beta, IL-2, IL-6, IL-17A, MCP1, and TNFalpha, improve anti-oxidant capacity, and suppress the phosphorylation of NF-kappaB and MAPKs. Quercetin 0-9 interleukin 1 beta Rattus norvegicus 123-131 29864931-7 2018 Furthermore, SA enhanced levels of malondialdehyde, tumor necrosis factor-alpha, interleukin-1beta and nitric oxide in testes. sodium arsenite 13-15 interleukin 1 beta Rattus norvegicus 81-98 29864946-5 2018 Furthermore, the interlukin (IL)-1beta-induced accumulation of nitric oxide (NO), matrixmetalloproteinase (MMP)-3) and MMP-13 could be suppressed by quercetin. Nitric Oxide 63-75 interleukin 1 beta Rattus norvegicus 17-38 29864919-10 2018 The combination of Dex and Taurine significantly suppressed the activation of NF-kappaB pathway via inhibiting P65 phosphorylation and P65 nuclear translocation, leading to the down-regulation of interleukin (IL)-6 and IL-1beta. Dexmedetomidine 19-22 interleukin 1 beta Rattus norvegicus 219-227 29080256-7 2018 RESULTS: High glucose (30 mmol/L) significantly decreased the cell viability of TAECs after being co-cultivated for 12 h and showed a time-dependent manner, and increased interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha secretion in TAECs. Glucose 14-21 interleukin 1 beta Rattus norvegicus 171-193 29864919-10 2018 The combination of Dex and Taurine significantly suppressed the activation of NF-kappaB pathway via inhibiting P65 phosphorylation and P65 nuclear translocation, leading to the down-regulation of interleukin (IL)-6 and IL-1beta. Taurine 27-34 interleukin 1 beta Rattus norvegicus 219-227 29865885-5 2018 Dunnione repressed cisplatin-induced inflammation in the kidneys as indicated by decreased TNF-alpha/IL-1beta levels, and reduced nuclear phosphorylated NF-kappaB p65. Cisplatin 19-28 interleukin 1 beta Rattus norvegicus 101-109 29620141-10 2018 In addition, expression levels of its downstream effectors IL-1beta, TNF-alpha and VEGF were attenuated by intrathecal treatment with LV-JMJD6, compared with those in the NS- and NC-treated CCI rats. CCI 190-193 interleukin 1 beta Rattus norvegicus 59-67 29600538-7 2018 SB-216763 suppressed cardiac and renal inflammatory cytokines levels (TNF-a, IL-1beta, and MCP-1). SB 216763 0-9 interleukin 1 beta Rattus norvegicus 77-85 29171721-10 2018 CONCLUSIONS: Heparan sulfate inhibits inflammation and improves wound healing by downregulating the NLRP3 inflammasome and cleaved IL-1beta during the wound healing process in diabetic rats. Heparitin Sulfate 13-28 interleukin 1 beta Rattus norvegicus 131-139 29864946-5 2018 Furthermore, the interlukin (IL)-1beta-induced accumulation of nitric oxide (NO), matrixmetalloproteinase (MMP)-3) and MMP-13 could be suppressed by quercetin. Quercetin 149-158 interleukin 1 beta Rattus norvegicus 17-38 29947321-11 2018 Furthermore, PA decreased serum levels of proinflammatory cytokines, which included TNF-alpha, IL-1beta and IL-6. Phytic Acid 13-15 interleukin 1 beta Rattus norvegicus 95-103 29614410-0 2018 Aluminum trichloride-induced hippocampal inflammatory lesions are associated with IL-1beta-activated IL-1 signaling pathway in developing rats. Aluminum Chloride 0-20 interleukin 1 beta Rattus norvegicus 82-90 29614410-10 2018 The above results demonstrate that AlCl3-induced HIL is associated with IL-1 signaling pathway, in which IL-1beta is a link. Aluminum Chloride 35-40 interleukin 1 beta Rattus norvegicus 105-113 29896261-8 2018 CD11b, TNF-alpha, IL-1beta and IL-6 levels were increased following remifentanil administration and these effects were counteracted by EA (all P<0.05). Remifentanil 68-80 interleukin 1 beta Rattus norvegicus 18-26 29962859-9 2018 Additionally, the levels of LDH and inflammatory cytokines, such as TNF-alpha, MCP-1, IL-1beta, and IL-6, in plasma were lower in Ang-(1-9) co-treated MCT group than in vehicle-treated MCT group. Monocrotaline 151-154 interleukin 1 beta Rattus norvegicus 86-94 29777942-9 2018 ZOL-PBM showed significant improvement in some parameters compared to ZOL, such as positive repair tissue, higher NFBT, greater amount of mature collagen fibers, besides TNFalpha and IL-1beta immunoreactivity decrease. zol-pbm 0-7 interleukin 1 beta Rattus norvegicus 183-191 29749492-9 2018 The expression levels of tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta were significantly reduced (P<0.05) in the spinal cord tissues of the dexmedetomidine group, compared with those in the control group of rats. Dexmedetomidine 159-174 interleukin 1 beta Rattus norvegicus 63-85 29749492-12 2018 Taken together, dexmedetomidine improved the locomotor activity of the rats through the inhibition of edema, reduction in the expression levels of TNF-alpha and IL-1beta, and inhibition of the induction of apoptosis. Dexmedetomidine 16-31 interleukin 1 beta Rattus norvegicus 161-169 29953508-8 2018 Interleukin-1-beta and interferon-gamma also increase mitochondrial superoxide levels (P < 0.05), which may reinforce the inhibition of pyruvate oxidation, and cause a modest (20%) but significant (P < 0.01) loss of INS-1E cells. Superoxides 68-78 interleukin 1 beta Rattus norvegicus 0-18 29653194-11 2018 Agomelatine treatment during epileptogenesis exerted a clear antidepressant effect by suppressing all behavioral hallmarks, reducing plasma IL-1beta levels and preventing microgliosis and astrogliosis in specific limbic regions. agomelatine 0-11 interleukin 1 beta Rattus norvegicus 140-148 28605990-10 2018 miR-25 protected PC-12 cells against H2O2-induced oxidative damage, as evidenced by significant suppression in cell apoptosis, increase in cell viability, decrease in the level of ROS, HIF-alpha and gammaH2A, and decrease in inflammatory mediators (IL-1beta, TNF-alpha, IL-6, and MCP-1). PC 12 ester 17-22 interleukin 1 beta Rattus norvegicus 249-257 28605990-10 2018 miR-25 protected PC-12 cells against H2O2-induced oxidative damage, as evidenced by significant suppression in cell apoptosis, increase in cell viability, decrease in the level of ROS, HIF-alpha and gammaH2A, and decrease in inflammatory mediators (IL-1beta, TNF-alpha, IL-6, and MCP-1). Hydrogen Peroxide 37-41 interleukin 1 beta Rattus norvegicus 249-257 30050432-0 2018 Specnuezhenide Decreases Interleukin-1beta-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats. nuezhenide 0-14 interleukin 1 beta Rattus norvegicus 25-42 29953508-8 2018 Interleukin-1-beta and interferon-gamma also increase mitochondrial superoxide levels (P < 0.05), which may reinforce the inhibition of pyruvate oxidation, and cause a modest (20%) but significant (P < 0.01) loss of INS-1E cells. Pyruvic Acid 139-147 interleukin 1 beta Rattus norvegicus 0-18 29944647-8 2018 Moreover, the injection of SB203580 could inhibit the inflammatory reactions and the increased expression of IL-1beta at both mRNA and protein levels. SB 203580 27-35 interleukin 1 beta Rattus norvegicus 109-117 30046341-6 2018 In addition, levels of TNF-alpha, IL-6, and IL-1beta in XDD-treated group were significantly lower compared to the model group. xdd 56-59 interleukin 1 beta Rattus norvegicus 44-52 29943090-8 2018 In macrophage culture, SIM-PPi inhibited LPS-induced pro-inflammatory cytokines (IL-1beta, IL-6). sim-ppi 23-30 interleukin 1 beta Rattus norvegicus 81-89 29673592-9 2018 Compared to the HS group, VC treatment led to a remarkable reduction in the kidney pathological score and CRE,BUN,TNF-alpha, and IL-1beta levels (P < 0.05), and a significant increase in Vitamin C, SOD, and RAFHR levels in the plasma (P < 0.05). Ascorbic Acid 26-28 interleukin 1 beta Rattus norvegicus 129-137 29929501-13 2018 Further, it reduced the expression of inflammatory factors that are mediated by NLRP3 through the NLRP3-caspase-1-IL-1beta/IL-18 signaling pathway, which makes naringin a potentially novel treatment for DKD disease. naringin a 160-170 interleukin 1 beta Rattus norvegicus 114-122 29950892-7 2018 Oxycodone at 50 and 100 ng/mL could significantly suppress LPS-induced production of TNF-alpha and IL-1beta and the expression of TNF-alphamRNA, IL-1betamRNA, and TGF-beta1/smad2/3 signaling pathway. Oxycodone 0-9 interleukin 1 beta Rattus norvegicus 99-107 29970985-17 2018 Sirt3 activation could decrease NLRP3 and interleukin-1beta levels through deacetylating SOD2 and scavenging ROS. Reactive Oxygen Species 109-112 interleukin 1 beta Rattus norvegicus 42-59 29730170-10 2018 Besides, rosiglitazone administration significantly decreased the levels of TNF-alpha, IL-1beta, SOD and MDA in hippocampus. Rosiglitazone 9-22 interleukin 1 beta Rattus norvegicus 87-95 30018712-9 2018 Western blot data indicated that NADH promoted the microtubule associated protein 1A/1B-light chain 3(LC3)-I to LC3II and the expression of IL-1beta and TNFalpha decreased in a dose dependent manner. NAD 33-37 interleukin 1 beta Rattus norvegicus 140-148 29730170-11 2018 Compared with rosiglitazone group, 3-MA administration, but not Compound C administration, significantly increased the levels of TNF-alpha, IL-1beta, SOD and MDA in hippocampus. 3-methyladenine 35-39 interleukin 1 beta Rattus norvegicus 140-148 29571019-0 2018 Involvement of estrogen receptors in silibinin protection of pancreatic beta-cells from TNFalpha- or IL-1beta-induced cytotoxicity. Silybin 37-46 interleukin 1 beta Rattus norvegicus 101-109 29928231-8 2018 The effects of CAR on the inflammatory response in interleukin (IL)-1beta-stimulated FLSs under a high glucose environment were evaluated by real-time quantitative polymerase chain reaction, western blotting, flow cytometry, and immunofluorescence. Glucose 103-110 interleukin 1 beta Rattus norvegicus 51-73 29942148-13 2018 The increased expression of tumor necrosis factor-alpha, interleukin-1 beta, and calcitonin gene-related peptide in CM group were significantly decreased by PNU-282987 and aggravated by alpha-bungarotoxin. N-neopentyl-N-nitrosourea 157-160 interleukin 1 beta Rattus norvegicus 57-75 29942258-7 2018 Moreover, TSA altered cytokine secretion by reducing the pro-inflammatory cytokines IL-1beta, IL-10, IL-12, and TGF-beta. trichostatin A 10-13 interleukin 1 beta Rattus norvegicus 84-92 29928231-10 2018 Moreover, CAR alleviated MMP-3 and MMP-13 expression levels by decreasing reactive oxygen species content and suppressing nuclear translocation of NF-kappaB p65 on IL-1beta-induced FLSs in a high glucose environment. Glucose 196-203 interleukin 1 beta Rattus norvegicus 164-172 30002711-11 2018 Moreover, obestatin administered at a dose of 8 or 16 nmol/kg/dose significantly reduced mucosal concentration of IL-1beta and activity of myeloperoxidase (p < 0.05). Ghrelin 10-19 interleukin 1 beta Rattus norvegicus 114-122 29567541-5 2018 Compared with TNBS alone, epiisopiloturine at 1 mg/kg reduced the macroscopic and microscopic scores, wet weight of the colon, and neutrophilic infiltration and expression of the pro-inflammatory cytokine IL-1beta. epiisopiloturine 26-42 interleukin 1 beta Rattus norvegicus 205-213 29571019-4 2018 This study reports the effect of silibinin on the rat pancreatic beta-cell line, INS-1, damaged with pro-inflammatory cytokine, TNFalpha or IL-1beta. Silybin 33-42 interleukin 1 beta Rattus norvegicus 140-148 29567541-7 2018 Animals treated with epiisopiloturine exhibited reduced immunostaining for IL-1beta, iNOS, and COX-2 and reduced cell count per field. epiisopiloturine 21-37 interleukin 1 beta Rattus norvegicus 75-83 29752991-12 2018 Also, blood levels of CGRP, PACAP, and pro-inflammatory cytokines (TNF-alpha and IL-1beta) significantly decreased by CBL administration. cerebrolysin 118-121 interleukin 1 beta Rattus norvegicus 81-89 29587238-8 2018 ZO was able to reduce the levels of the inflammatory markers NF-kappaB, TNF-alpha, IL-1beta, IL-6, COX-2 and iNOS in CP-induced ovarian and uterine damage. zingerone 0-2 interleukin 1 beta Rattus norvegicus 83-91 29528526-12 2018 Treatment with minocycline, an inhibitor of microglial activation, decreased IL-1beta, TNFalpha and MMP9 mRNA expression in the RVLM, and increased IL-6 mRNA expression in the RVLM and PVH of rats exposed to AH. Minocycline 15-26 interleukin 1 beta Rattus norvegicus 77-85 29573618-10 2018 Hyperammonemic rats showed elevated levels of cerebral TNF-alpha, IL-1beta and glutamine as well as increased activity and expression of Na+/K+-ATPase, effects that were significantly reversed by UMB. 7-hydroxycoumarin 196-199 interleukin 1 beta Rattus norvegicus 66-74 29637744-0 2018 The group VIA calcium-independent phospholipase A2 and NFATc4 pathway mediates IL-1beta-induced expression of chemokines CCL2 and CXCL10 in rat fibroblasts. Calcium 14-21 interleukin 1 beta Rattus norvegicus 79-87 29904426-9 2018 Furthermore, the protein levels of p-p65, p-ERK1/2, COX-2, PGE2, IL-1beta and TNF-alpha were significantly upregulated following CFA injection, while they were suppressed by dezocine pretreatment. dezocine 174-182 interleukin 1 beta Rattus norvegicus 65-73 29917216-7 2018 Enzyme-linked immunosorbent assay revealed inhibition of interleukin-1beta expression and nitric oxide generation on treatment with glucosamine methyl ester. glucosamine methyl ester 132-156 interleukin 1 beta Rattus norvegicus 57-74 29904397-7 2018 Treatment with thymoquinone decreased inflammatory response [measured by levels of tumor necrosis factor alpha, interleukin (IL)-1beta, IL-6 and IL-18], oxidative stress (measured by levels of superoxide dismutase, catalase, glutathione and malondialdehyde) and cell apoptosis (measured by levels of caspase-3 and caspase-9) in SCI rats. thymoquinone 15-27 interleukin 1 beta Rattus norvegicus 112-134 29637744-3 2018 We obtained evidence that the induction of some chemokines is regulated by group VIA calcium-independent phospholipase A2 beta (iPLA2 beta) in IL-1beta-stimulated rat fibroblastic 3Y1 cells. Calcium 85-92 interleukin 1 beta Rattus norvegicus 143-151 29637744-10 2018 Additionally, the transcriptional activation of nuclear factor of activated T-cell proteins (NFATs), but not nuclear factor-kappaB, by IL-1beta stimulation was markedly attenuated by the iPLA2 inhibitor bromoenol lactone, and NFATc4 knockdown markedly attenuated the IL-1beta-induced expression of both CCL2 and CXCL10. 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one 203-220 interleukin 1 beta Rattus norvegicus 135-143 29932348-9 2018 The levels of iNOS, IL-1beta, and TNF-alpha were higher in CCI group (p < .05). CCI 59-62 interleukin 1 beta Rattus norvegicus 20-28 29486618-0 2018 Involvement of IL-1beta and IL-6 in antiarrhythmic properties of atorvastatin in ouabain-induced arrhythmia in rats. Atorvastatin 65-77 interleukin 1 beta Rattus norvegicus 15-23 29486618-7 2018 Injection of ouabain elevated the atrial levels of IL-1beta, IL-6, and TNF-alpha, while pretreatment of animals with atorvastatin could reverse the ouabain-induced increase in atrial IL-1beta and IL-6 (p < .01 and p < .05, respectively). Ouabain 13-20 interleukin 1 beta Rattus norvegicus 51-59 29486618-7 2018 Injection of ouabain elevated the atrial levels of IL-1beta, IL-6, and TNF-alpha, while pretreatment of animals with atorvastatin could reverse the ouabain-induced increase in atrial IL-1beta and IL-6 (p < .01 and p < .05, respectively). Atorvastatin 117-129 interleukin 1 beta Rattus norvegicus 51-59 29486618-8 2018 CONCLUSIONS: It is concluded that observed antiarrhythmic effects of atorvastatin might be attributed to modulation of some inflammatory cytokines, at least IL-1beta and IL-6. Atorvastatin 69-81 interleukin 1 beta Rattus norvegicus 157-165 29290042-8 2018 Furthermore, excessive production of IL-6, IL-1beta and TNF-alpha could be reduced with zeaxanthin treatment. Zeaxanthins 88-98 interleukin 1 beta Rattus norvegicus 43-51 29525080-6 2018 RESULTS: We found that combined rosuvastatin and resveratrol pretreatment not only significantly decreased the neurologic defective score, cerebral infarct volume, the levels of caspase-3, and Interleukin-1beta (IL-1beta) but also significantly increased the ratios of Bcl-2/Bax and LC3II/LC3I, as well as the level of Becline-1, compared with resveratrol alone or rosuvastatin alone pretreatment group. Rosuvastatin Calcium 32-44 interleukin 1 beta Rattus norvegicus 193-210 29525080-6 2018 RESULTS: We found that combined rosuvastatin and resveratrol pretreatment not only significantly decreased the neurologic defective score, cerebral infarct volume, the levels of caspase-3, and Interleukin-1beta (IL-1beta) but also significantly increased the ratios of Bcl-2/Bax and LC3II/LC3I, as well as the level of Becline-1, compared with resveratrol alone or rosuvastatin alone pretreatment group. Rosuvastatin Calcium 32-44 interleukin 1 beta Rattus norvegicus 212-220 29525080-6 2018 RESULTS: We found that combined rosuvastatin and resveratrol pretreatment not only significantly decreased the neurologic defective score, cerebral infarct volume, the levels of caspase-3, and Interleukin-1beta (IL-1beta) but also significantly increased the ratios of Bcl-2/Bax and LC3II/LC3I, as well as the level of Becline-1, compared with resveratrol alone or rosuvastatin alone pretreatment group. Resveratrol 49-60 interleukin 1 beta Rattus norvegicus 193-210 29525080-6 2018 RESULTS: We found that combined rosuvastatin and resveratrol pretreatment not only significantly decreased the neurologic defective score, cerebral infarct volume, the levels of caspase-3, and Interleukin-1beta (IL-1beta) but also significantly increased the ratios of Bcl-2/Bax and LC3II/LC3I, as well as the level of Becline-1, compared with resveratrol alone or rosuvastatin alone pretreatment group. Resveratrol 49-60 interleukin 1 beta Rattus norvegicus 212-220 28846566-9 2018 In addition, DCA reduced the messenger RNA expression of tumor necrosis factor alpha and interleukin 1beta in brain hippocampus and cortex after ROSC. Dichloroacetic Acid 13-16 interleukin 1 beta Rattus norvegicus 89-106 29649568-6 2018 We also found that honokiol suppressed the phosphorylation of NF-kB and JNK, and activation of TXNIP-NLRP3 inflammasome in H2O2-stimulated nucleus pulposus cells, thereby inhibiting the activation of downstream inflammatory mediators such as Interleukin-1beta. honokiol 19-27 interleukin 1 beta Rattus norvegicus 242-259 29803222-0 2018 Serum amyloid A primes microglia for ATP-dependent interleukin-1beta release. Adenosine Triphosphate 37-40 interleukin 1 beta Rattus norvegicus 51-68 29649568-8 2018 Thus, our results demonstrate that honokiol inhibited the H2O2 induced apoptosis, oxidative stress, and inflammatory responses through the depression of TXNIP/NLRP3/caspase-1/ Interleukin - 1beta signaling axis and the activation of NF-kB and JNK. honokiol 35-43 interleukin 1 beta Rattus norvegicus 176-195 29802529-6 2018 Inhibition of NLRP3 by glyburide strongly suppressed the expression of NLRP3 inflammasome proteins and IL-1beta, and markedly reduced brain tissue damage. Glyburide 23-32 interleukin 1 beta Rattus norvegicus 103-111 29803222-3 2018 IL-1beta release is promoted by ATP acting at the purinergic P2X7 receptor (P2X7R) in cells primed with toll-like receptor (TLR) ligands. Adenosine Triphosphate 32-35 interleukin 1 beta Rattus norvegicus 0-8 29803222-7 2018 RESULTS: Apo-SAA stimulated, in a time-dependent manner, the expression of NLRP3, IL-1beta, and TNF-alpha in cortical microglia, and produced a concentration-dependent increase in the intracellular content of IL-1beta in these cells. apo-saa 9-16 interleukin 1 beta Rattus norvegicus 82-90 29803222-7 2018 RESULTS: Apo-SAA stimulated, in a time-dependent manner, the expression of NLRP3, IL-1beta, and TNF-alpha in cortical microglia, and produced a concentration-dependent increase in the intracellular content of IL-1beta in these cells. apo-saa 9-16 interleukin 1 beta Rattus norvegicus 209-217 29803222-8 2018 A 2-h "priming" of the microglia with Apo-SAA followed by addition of ATP for 1 h, resulting in a robust release of IL-1beta into the culture medium, with a concomitant reduction in its intracellular content. Adenosine Triphosphate 70-73 interleukin 1 beta Rattus norvegicus 116-124 29803222-9 2018 The selective P2X7R antagonist A740003 blocked ATP-dependent release of IL-1beta. (N-(1-(((cyanoimino)(5-quinolinylamino) methyl) amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide) 31-38 interleukin 1 beta Rattus norvegicus 72-80 29803222-9 2018 The selective P2X7R antagonist A740003 blocked ATP-dependent release of IL-1beta. Adenosine Triphosphate 47-50 interleukin 1 beta Rattus norvegicus 72-80 29741190-8 2018 Hippocampus gene expressions were affected by age (an increase of TNF-alpha), sucrose treatment (an increase of IL-1beta and IL-6), and micronutrient supplementation (a decrease of heme oxygenase, catalase, glutathione peroxidase, TNF-alpha, and Nrf2). Sucrose 78-85 interleukin 1 beta Rattus norvegicus 112-120 29627302-6 2018 In RA cells, TNF-alpha, IL-1beta and MCP-1 in the supernatant and the proliferation index in the cell cycle were decreased by 5, 12.5, and 25 muM Res and 20 nM 17beta-estradiol treatment 24 h before Abeta1-42. Estradiol 160-176 interleukin 1 beta Rattus norvegicus 24-32 29627302-7 2018 Similarly, in N9 microglial, the levels of IL-1beta, IL-6 and NO in the supernatant and CD40 and MHCII in the 10, 20, and 40 muM Res and 20 nM 17beta-estradiol treatment groups decreased markedly compared with the Abeta1-42 treatment group. 17beta 143-149 interleukin 1 beta Rattus norvegicus 43-51 29996376-7 2018 Compared with group saline once/week, the mRNA levels of IL-1beta, TGF-beta, Col I, Col III and CTGF were significantly increased in group crystalline silica 6.25 mg/week (P<0.05) . Silicon Dioxide 151-157 interleukin 1 beta Rattus norvegicus 57-65 29649568-8 2018 Thus, our results demonstrate that honokiol inhibited the H2O2 induced apoptosis, oxidative stress, and inflammatory responses through the depression of TXNIP/NLRP3/caspase-1/ Interleukin - 1beta signaling axis and the activation of NF-kB and JNK. Hydrogen Peroxide 58-62 interleukin 1 beta Rattus norvegicus 176-195 29332858-8 2018 Increased production of IL-1beta and MDA by cisplatin was inhibited by TPP, while it was not inhibited by thiamine. Cisplatin 44-53 interleukin 1 beta Rattus norvegicus 24-32 29867706-10 2018 UA (10 and 20 mg/kg) treatment significantly decreased the neurological deficit scores, infarct volume, apoptotic cells, and IL-1beta, TNF-alpha, and IL-6 concentrations. ursolic acid 0-2 interleukin 1 beta Rattus norvegicus 125-133 29780671-7 2018 TNF-alpha and IL-1beta induced cell damage, measured by impedance and MTT assay, which was attenuated by alpha-MSH (1 and 10 pM). monooxyethylene trimethylolpropane tristearate 70-73 interleukin 1 beta Rattus norvegicus 14-22 29776417-13 2018 Finally, PTZ kindling increases the expression of NLRP1 inflammasome complexes and the levels of inflammatory cytokines IL-1beta, IL-18, IL-6, and TNF-alpha, which are all attenuated by SN in a dose- dependent manner. Pentylenetetrazole 9-12 interleukin 1 beta Rattus norvegicus 120-128 29776417-13 2018 Finally, PTZ kindling increases the expression of NLRP1 inflammasome complexes and the levels of inflammatory cytokines IL-1beta, IL-18, IL-6, and TNF-alpha, which are all attenuated by SN in a dose- dependent manner. sinomenine 186-188 interleukin 1 beta Rattus norvegicus 120-128 29844659-11 2018 Simultaneously tanshinol could regulate nuclear factor kappa B signaling pathway to inhibit expression of inflammation factors, including transforming growth factor-beta, tumor necrosis factor-alpha, Cox-2, interleukin-1beta, and interleukin-6. tanshinol 15-24 interleukin 1 beta Rattus norvegicus 207-224 29332858-8 2018 Increased production of IL-1beta and MDA by cisplatin was inhibited by TPP, while it was not inhibited by thiamine. Thiamine Pyrophosphate 71-74 interleukin 1 beta Rattus norvegicus 24-32 29720230-16 2018 Additionally, increased plasma urate level abolished the reduction of URAT1 expression, the increase in the expression of interleukin-1beta, and the number of ionized calcium-binding adaptor molecule 1-positive microglia along with changes in their morphology. Uric Acid 31-36 interleukin 1 beta Rattus norvegicus 122-139 29854833-6 2018 ERK1/2 and p38 activators (t-butylhydroquinone, tBHQ, and U-46619) reversed the suppressive effect of PAR4 activation on IL-1beta and iNOS expression, whereas ERK1/2 and p38 inhibitors (PD98059 and SB203580) reversed the suppressive effect of PAR4 activation on P2X7 and tryptase expression. 2-tert-butylhydroquinone 27-46 interleukin 1 beta Rattus norvegicus 121-129 29854833-6 2018 ERK1/2 and p38 activators (t-butylhydroquinone, tBHQ, and U-46619) reversed the suppressive effect of PAR4 activation on IL-1beta and iNOS expression, whereas ERK1/2 and p38 inhibitors (PD98059 and SB203580) reversed the suppressive effect of PAR4 activation on P2X7 and tryptase expression. 2-tert-butylhydroquinone 48-52 interleukin 1 beta Rattus norvegicus 121-129 29867457-6 2018 Furthermore, alpha-asarone significantly reduced the TNF-alpha, IL-1beta, IL-6, monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 2 (MIP-2), and inducible nitric oxide synthase (iNOS) levels but increased the IL-4, IL-10, and arginase 1 levels at 24 h after SCI. asarone 13-26 interleukin 1 beta Rattus norvegicus 64-72 29785089-4 2018 Results: The results showed that Schisandrin B decreased IL-1beta-induced upregulation of matrix metalloproteinase 3 (MMP3), MMP13, IL-6, and inducible nitric oxide synthase (iNOS) and increased IL-1beta-induced downregulation of collagen II, aggrecan, and sox9 as well. schizandrin B 33-46 interleukin 1 beta Rattus norvegicus 57-65 29785089-4 2018 Results: The results showed that Schisandrin B decreased IL-1beta-induced upregulation of matrix metalloproteinase 3 (MMP3), MMP13, IL-6, and inducible nitric oxide synthase (iNOS) and increased IL-1beta-induced downregulation of collagen II, aggrecan, and sox9 as well. schizandrin B 33-46 interleukin 1 beta Rattus norvegicus 195-203 29785089-5 2018 Schisandrin B significantly decreased IL-1beta-induced p65 phosphorylation and nuclear translocation of p65 in rat chondrocytes. schizandrin B 0-13 interleukin 1 beta Rattus norvegicus 38-46 29853790-7 2018 In addition, there was a downregulation of the TNBS-induced increase in the activity of iNOS and levels of Cox-2, TNF-alpha, and IL-1beta while the protein expression of NF-kappaB was significantly unregulated after administration of H-PHL. Trinitrobenzenesulfonic Acid 47-51 interleukin 1 beta Rattus norvegicus 129-137 29477473-8 2018 The elevated levels of serum pro-inflammatory cytokines, IL-1beta and TNF-alpha, as well as PGE-2 and LTB-4 were decreased in non-diabetic and diabetic wounded rats with quercetin and LLLT while the lowered level of serum anti-inflammatory cytokine, IL-10, was increased. Quercetin 170-179 interleukin 1 beta Rattus norvegicus 57-65 29518435-6 2018 Furthermore, ZFE effectively modulated the mRNA expression of redox-sensitive transcription factors, such as nuclear factor (erythroid-derived 2)-like 2 and heme oxygenase-1, downregulated the expression of p38 mitogen-activated protein kinase, and upregulated that of vascular endothelial growth factor A and interleukin-1beta in AcOH-induced colitis in rats. zfe 13-16 interleukin 1 beta Rattus norvegicus 310-327 29427595-6 2018 Meanwhile, the expression of P2X7 receptors, GFAP, TNF-alpha and IL-1beta in the hippocampus of the rats with comorbidity of DNP and DP was significantly increased compared with the control rats, and palmatine treatment could decrease the expression. dnp 125-128 interleukin 1 beta Rattus norvegicus 65-73 29427595-8 2018 The results of this study suggest that palmatine can alleviate the comorbidity of DNP and DP by inhibiting the expression of P2X7 receptors in the hippocampus, and its action may be related to suppression of the phosphorylation of ERK1/2 and the release of TNF-alpha and IL-1beta in the hippocampus. palmatine 39-48 interleukin 1 beta Rattus norvegicus 271-279 29743895-5 2018 20 and 40 mg/kg osthole decreased the level of IL-1beta, TNF-alpha and IL-6 in rats and ameliorated oxidative stress in serum evaluated using ELISA kits. osthol 16-23 interleukin 1 beta Rattus norvegicus 47-55 29743895-9 2018 Conclusion: These results collectively demonstrated that osthole improves collagen-induced arthritis in a rat model and IL-1beta-treated SW982 cells through inhibiting inflammation and cellular stress in vivo and in vitro, and osthole might be a promising therapeutic agent for RA. osthol 57-64 interleukin 1 beta Rattus norvegicus 120-128 28621212-9 2018 Meth upregulated the gene expression of IL-6, IL-1beta, and TNFalpha and downregulated the expression of Arg-1, IL-10, and KLF4. Methamphetamine 0-4 interleukin 1 beta Rattus norvegicus 46-54 28621212-10 2018 Meth could also upregulate the protein expression of IL-1beta and TNF alpha and downregulate the expression of Arg-1 and KLF4. Methamphetamine 0-4 interleukin 1 beta Rattus norvegicus 53-61 29488614-6 2018 THS caused significant reductions in heart rate and mean arterial blood pressure, and was associated with significant increases in tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, p-p38MAPK, NF-kappaB and AP-1 activation, in addition to TLR4 expression, in the lung. THYMIDINE-5'-(DITHIO)PHOSPHATE 0-3 interleukin 1 beta Rattus norvegicus 180-188 29484377-11 2018 The levels of TNF-alpha, IL-1beta and IL-6 in the peripheral serum of the DML group were significantly suppressed compared with those of the DM group. dml 74-77 interleukin 1 beta Rattus norvegicus 25-33 29484377-11 2018 The levels of TNF-alpha, IL-1beta and IL-6 in the peripheral serum of the DML group were significantly suppressed compared with those of the DM group. dm 74-76 interleukin 1 beta Rattus norvegicus 25-33 29484377-12 2018 It was also observed that the mRNA expression levels of TNF-alpha, IL-6, IL-1beta, MCP-1, ICAM-1 and NOX4 in the sciatic nerve were attenuated in the DML group. dml 150-153 interleukin 1 beta Rattus norvegicus 73-81 29520818-6 2018 RESULTS: Colchicine treatment significantly reduced IL-1beta, IL-8, RANKL, RANKL/OPG, TOS, OSI, and bone volume ratio levels, and increased TAS levels compared to group P (p < 0.05). Colchicine 9-19 interleukin 1 beta Rattus norvegicus 52-60 29488608-9 2018 Interleukin (IL)-1beta and tumor necrosis factor alpha levels in the GdCl3 group were significantly increased compared with those in the control and saline groups (P<0.01). gadolinium chloride 69-74 interleukin 1 beta Rattus norvegicus 0-22 29432804-11 2018 RESULTS: Nitrate supplementation in diabetic rats significantly improved glucose tolerance, lipid profiles, and catalase activity as well as decreased gluconeogenesis, fasting glucose, insulin, and IL-1beta; although it had no significant effect on GSIS, islet insulin content, HbA1c, and serum TBARS. Nitrates 9-16 interleukin 1 beta Rattus norvegicus 198-206 29694352-6 2018 Gene expression and protein concentration of COX-1, COX-2, IL-1beta, TNF-alpha, RANKL and M-CSF were significantly higher in the CTF group than in the control group. CHEMBL408967 129-132 interleukin 1 beta Rattus norvegicus 59-67 30081998-36 2018 IL-1beta, IL-6 and TNF-alphadecreased after DMF exposure, in which IL-1beta significantly decreased on day 28 after DMF exposure when compared with day 0[(34. Dimethylformamide 44-47 interleukin 1 beta Rattus norvegicus 0-8 30081998-36 2018 IL-1beta, IL-6 and TNF-alphadecreased after DMF exposure, in which IL-1beta significantly decreased on day 28 after DMF exposure when compared with day 0[(34. Dimethylformamide 44-47 interleukin 1 beta Rattus norvegicus 67-75 30081998-36 2018 IL-1beta, IL-6 and TNF-alphadecreased after DMF exposure, in which IL-1beta significantly decreased on day 28 after DMF exposure when compared with day 0[(34. Dimethylformamide 116-119 interleukin 1 beta Rattus norvegicus 67-75 29061383-7 2018 In contrast, ATP administered alone to glial cells at high micromolar concentrations significantly stimulated the release of PNP within 1 h, an effect not modified by LPS presence, whereas IL-1beta secretion was stimulated by ATP only in cells primed for 2 h with LPS. Adenosine Triphosphate 226-229 interleukin 1 beta Rattus norvegicus 189-197 29694352-8 2018 After orthodontic tooth movement, the expression of IL-1beta, TNF-alpha, RANKL and M-CSF decreased in the loxoprofen group than in the control group by immunohistochemical staining. loxoprofen 106-116 interleukin 1 beta Rattus norvegicus 52-60 29609691-6 2018 Moreover, chrysophanol effectively relieved HFD-induced inflammation, as demonstrated by the reduction of interleukin (IL)-6 and IL-1beta and the elevation of IL-10. chrysophanic acid 10-22 interleukin 1 beta Rattus norvegicus 129-137 29678208-2 2018 IL-1beta induces cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2). Dinoprostone 46-62 interleukin 1 beta Rattus norvegicus 0-8 29678208-2 2018 IL-1beta induces cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2). Dinoprostone 64-68 interleukin 1 beta Rattus norvegicus 0-8 29678208-10 2018 RESULTS: IL-1beta upregulated Nav1.7 mRNA and protein expressions in the TG explants, whereas NS398, PF-04418948, H89, or PKI-(6-22)-amide could all block this upregulation, and forskolin could also upregulate Nav1.7 mRNA and protein expressions. Amides 133-138 interleukin 1 beta Rattus norvegicus 9-17 29678208-10 2018 RESULTS: IL-1beta upregulated Nav1.7 mRNA and protein expressions in the TG explants, whereas NS398, PF-04418948, H89, or PKI-(6-22)-amide could all block this upregulation, and forskolin could also upregulate Nav1.7 mRNA and protein expressions. Colforsin 178-187 interleukin 1 beta Rattus norvegicus 9-17 29678208-13 2018 Moreover, microinjection of fluorocitrate into the TGs completely blocked TMJ inflammation-induced activation of SGCs and the upregulation of IL-1beta and COX-2 in the SGCs, and phospho-CREB and Nav1.7 in the neurons and alleviated inflammation-induced TMJ hypernociception. fluorocitrate 28-41 interleukin 1 beta Rattus norvegicus 142-150 29678208-14 2018 CONCLUSIONS: Glial IL-1beta upregulated neuronal Nav1.7 expression via the crosstalk between signaling pathways of the glial IL-1beta/COX-2/PGE2 and the neuronal EP2/PKA/CREB/Nav1.7 in TG contributing to TMJ inflammatory hypernociception. Dinoprostone 140-144 interleukin 1 beta Rattus norvegicus 19-27 29678208-14 2018 CONCLUSIONS: Glial IL-1beta upregulated neuronal Nav1.7 expression via the crosstalk between signaling pathways of the glial IL-1beta/COX-2/PGE2 and the neuronal EP2/PKA/CREB/Nav1.7 in TG contributing to TMJ inflammatory hypernociception. Dinoprostone 140-144 interleukin 1 beta Rattus norvegicus 125-133 29849861-6 2018 Gossypol injection significantly decreased the semen quality and testosterone level that resulted from the elevation of testicular reactive oxygen and nitrogen species (TBARS and NO), TNF-alpha, TNF-alpha-converting enzyme, and interleukins (IL-1beta, IL-6, and IL-18) by 230, 180, 12.5, 97.9, and 300%, respectively, while interleukin-12 and tissue inhibitors of metalloproteinases-3 were significantly decreased by 59 and 66%, respectively. Gossypol 0-8 interleukin 1 beta Rattus norvegicus 242-250 29440071-8 2018 Systemic administration of 2-deoxyglucose after rodent MI normalized the hyperpolarized [1-13C]lactate signal in healing myocardial segments at day 3 and also caused dose-dependent improvement in IL (interleukin)-1beta expression in infarct tissue without impairing the production of key reparative cytokines. Deoxyglucose 27-41 interleukin 1 beta Rattus norvegicus 196-218 29627845-9 2018 Levels of IL-1beta, TNF-alpha, and IL-18 were significantly reduced after EPA treatment. Eicosapentaenoic Acid 74-77 interleukin 1 beta Rattus norvegicus 10-18 29620048-8 2018 SIN administration decreased the levels of TNF-alpha, IL-1beta, and IL-6. sinomenine 0-3 interleukin 1 beta Rattus norvegicus 54-62 29102165-8 2018 IL-1beta levels demonstrated a significant reduction (p < .05) in the PG group when compared to saline. Pregabalin 73-75 interleukin 1 beta Rattus norvegicus 0-8 29499191-11 2018 Moreover, L-carnitine significantly downregulated the levels of the early response proinflammatory cytokines TNF-alpha, IL-6, and IL-1beta. Carnitine 10-21 interleukin 1 beta Rattus norvegicus 130-138 29031875-12 2018 In addition, t-TUCB decreased the levels of proinflammatory cytokines, including IL-1beta, IL-6, IL-10, tumor necrosis factor-alpha (TNF-alpha) and NF-kappaB, within cirrhotic hepatic tissue. 4-(4-(3-(4-trifluoromethoxy-phenyl)ureido)cyclohexyloxy)benzoic acid 13-19 interleukin 1 beta Rattus norvegicus 81-89 29102165-8 2018 IL-1beta levels demonstrated a significant reduction (p < .05) in the PG group when compared to saline. Sodium Chloride 99-105 interleukin 1 beta Rattus norvegicus 0-8 29881417-10 2018 The increased levels of IL-1beta and IL-6 stimulated by TNF-alpha on CMECs were also decreased after treating with 4-ACGC. 4-acgc 115-121 interleukin 1 beta Rattus norvegicus 24-32 29441689-12 2018 Compared with the vehicle/control, 1400W significantly: (i) limited development of mechanical hypersensitivity at 66 h post-SNA and of heat hypersensitivity at 42 h and at several time points tested thereafter; and (ii) increased the plasma concentrations of interleukin (IL)-1alpha, IL-1beta and IL-10 in the SNA rats. N-((3-(aminomethyl)phenyl)methyl)ethanimidamide 35-40 interleukin 1 beta Rattus norvegicus 284-292 29441689-13 2018 The findings suggest that 1400W might exert its analgesic effects by reducing iNOS and altering the balance between the pro-inflammatory (IL-1beta and IL-1alpha) and anti-inflammatory (IL-10) cytokines and that therapies targeting NO or its enzymes might be effective for the treatment of PNP. N-((3-(aminomethyl)phenyl)methyl)ethanimidamide 26-31 interleukin 1 beta Rattus norvegicus 138-146 29260240-5 2018 BzATP induced a local increase of TNF-alpha, IL-1beta, IL-6, and CINC-1 concentration and neutrophil migration into the knee joint. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 0-5 interleukin 1 beta Rattus norvegicus 45-53 29303018-0 2018 The beta2-adrenoceptor agonist clenbuterol reduces the neuroinflammatory response, neutrophil infiltration and apoptosis following intra-striatal IL-1beta administration to rats. Clenbuterol 31-42 interleukin 1 beta Rattus norvegicus 146-154 29303018-2 2018 In the present investigation, the effect of clenbuterol was assessed in a rat model of acute brain injury induced by intra-striatal administration of the pro-inflammatory cytokine IL-1beta. Clenbuterol 44-55 interleukin 1 beta Rattus norvegicus 180-188 29303018-9 2018 Treatment with clenbuterol attenuated all IL-1beta-induced changes in the striatum including MBS-2 immunoreactivity and TUNEL + staining. Clenbuterol 15-26 interleukin 1 beta Rattus norvegicus 42-50 29303018-10 2018 Clenbuterol also attenuated IL-1beta-induced expression of TNF-alpha in the liver and the increase in circulating CINC-1 concentrations. Clenbuterol 0-11 interleukin 1 beta Rattus norvegicus 28-36 29303018-11 2018 CONCLUSIONS: The results provide evidence that clenbuterol elicits anti-inflammatory effects, suppresses the peripheral acute phase response and reduces the infiltration of neutrophils and apoptotic response to acute IL-1beta-induced brain injury. Clenbuterol 47-58 interleukin 1 beta Rattus norvegicus 217-225 29303021-4 2018 The effect of AZ on rat AIA was evaluated by secondary hind paw swelling, arthritis index, TNF-alpha and IL-1beta serum levels and histological examination of ankle joint. Acetazolamide 14-16 interleukin 1 beta Rattus norvegicus 105-113 29303021-7 2018 RESULTS: AZ treatment could inhibit secondary hind paw swelling and arthritis index, reduce serum levels of TNF-alpha and IL-1beta, and ameliorate pathological changes of ankle joint in AIA rats. Acetazolamide 9-11 interleukin 1 beta Rattus norvegicus 122-130 29282807-7 2018 RESULTS: Compared with control rats, plasma levels of IL-1alpha, IL-1beta, IL-6, TNF-alpha, INF-gamma and MCP-1 were significantly upregulated in paclitaxel-treated rats. Paclitaxel 146-156 interleukin 1 beta Rattus norvegicus 65-73 29282807-17 2018 Nevertheless, our findings that pharmacological blockade of TNF-alpha, IL-1beta and MCP-1 attenuated both evoked and spontaneous pain suggest that strategies that target inhibition of these cytokines may be effective in treating CIPNP. cipnp 229-234 interleukin 1 beta Rattus norvegicus 71-79 29393346-8 2018 IL-1beta-induced activation of extracellular signal-regulated kinase was downregulated by the HDAC inhibitor Trichostatin A, but not significantly by PCI-34051. trichostatin A 109-123 interleukin 1 beta Rattus norvegicus 0-8 29881429-9 2018 In rat paws with carrageenan, treatment with TFF (500 and 250 mg/kg) markedly inhibited the expression of IL-1beta and iNOS. trofosfamide 45-48 interleukin 1 beta Rattus norvegicus 106-114 29719465-10 2018 IL-1beta, IL-6, and tumor necrotizing factor-alpha levels significantly decreased after ginsenoside Rf treatment. Ginsenosides 88-99 interleukin 1 beta Rattus norvegicus 0-8 29397217-9 2018 CONCLUSIONS: Supplementation with omega-3 PUFAs can modulate the inflammatory response in rat AP, decreasing levels of TNF-alpha, IL-6, IL-1beta, and IL-17 but increasing levels of IL-10. Fatty Acids, Omega-3 34-47 interleukin 1 beta Rattus norvegicus 136-144 29392519-4 2018 We demonstrated that CCH increased tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), interleukin 6 (IL-6), and malondialdehyde (MDA), and decreased superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels. 1-acetyl-2-(coumariniminecarboxamide-3-yl)hydrazine 21-24 interleukin 1 beta Rattus norvegicus 76-93 29683497-13 2018 CONCLUSION: The findings of the present study suggest that testosterone depletion attenuates inflammatory bone resorption in ligature-induced periodontitis, which may be partly mediated via decreased production of IL-1beta. Testosterone 59-71 interleukin 1 beta Rattus norvegicus 214-222 29683499-12 2018 Testosterone supplementation significantly increased the inflammatory cell count, decreased the levels of IL-4, IL-10, IL-1beta, IL-6, and TNF-alpha; and increased VEGF and EGF. Testosterone 0-12 interleukin 1 beta Rattus norvegicus 119-127 29196833-8 2018 Furthermore, CS/GS + PBM decreased IL-1beta protein expression (p = 0.0359) and increased IL-10 (p = 0.028) and Col II imunoexpression (p = 0.0204) compared to CG. Cesium 13-15 interleukin 1 beta Rattus norvegicus 35-43 29196833-8 2018 Furthermore, CS/GS + PBM decreased IL-1beta protein expression (p = 0.0359) and increased IL-10 (p = 0.028) and Col II imunoexpression (p = 0.0204) compared to CG. pbm 21-24 interleukin 1 beta Rattus norvegicus 35-43 29436632-3 2018 Sparstolonin B attenuated the mRNA expression of proinflammatory cytokines interleukin (IL)-18, IL-6, IL-1beta, and IL-23, decreased the levels of tumor necrosis factor-alpha and interferon-gamma, and decreased caspase-3 activity and apoptosis regulator Bax protein expression in SCI rats. sparstolonin 0-12 interleukin 1 beta Rattus norvegicus 102-110 29411262-4 2018 reduced MA-induced mechanical allodynia and multiple methane treatments blocked activation of glial cells, decreased IL-1beta and TNF-alpha production and MMP-2 activity, and upregulated IL-10 expression in the spinal cord on day 10 post-MA. Methane 53-60 interleukin 1 beta Rattus norvegicus 117-125 29484390-0 2018 Paeoniflorin inhibits IL-1beta-induced chondrocyte apoptosis by regulating the Bax/Bcl-2/caspase-3 signaling pathway. peoniflorin 0-12 interleukin 1 beta Rattus norvegicus 22-30 29484390-11 2018 Treatment with 25 or 50 microM paeoniflorin markedly decreased the release of LDH and the ratio of apoptotic cells in interleukin (IL)-1beta-induced rat chondrocytes. peoniflorin 31-43 interleukin 1 beta Rattus norvegicus 118-140 29484390-15 2018 Therefore, paeoniflorin may exert its protective effect by inhibiting apoptosis in IL-1beta-induced rat chondrocytes and thus, may be an effective agent in the prevention and treatment of OA. peoniflorin 11-23 interleukin 1 beta Rattus norvegicus 83-91 29392519-4 2018 We demonstrated that CCH increased tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), interleukin 6 (IL-6), and malondialdehyde (MDA), and decreased superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels. 1-acetyl-2-(coumariniminecarboxamide-3-yl)hydrazine 21-24 interleukin 1 beta Rattus norvegicus 95-103 29350427-6 2018 RESULTS: In comparison with the control group, the colitis group showed significant increases in (1) micturition frequency during cystometry; (2) resiniferatoxin-induced freezing behavior (bladder pain); (3) the number of total and degranulated mast cells in the bladder; (4) the number of microglia in the L6 spinal cord, and (5) the expression of IL-1beta, CCL3, and BDNF mRNA in the L6 spinal cord. resiniferatoxin 146-161 interleukin 1 beta Rattus norvegicus 349-357 29243196-9 2018 Acetylsalicylic acid totally prevented the effect of homocysteine on acetylcholinesterase activity and catalase activity and immunocontent, as well as the ultrastructural changes, and partially prevented alterations on IL-1beta levels, superoxide dismutase activity, sulfhydryl content, and comet assay. Aspirin 0-20 interleukin 1 beta Rattus norvegicus 219-227 29164519-11 2018 Atorvastatin per se reduced the levels of the cytokines TNF-alpha and IL-1beta, and surprisingly, it reduced IL-10 and nerve growth factor levels in the striatum. Atorvastatin 0-12 interleukin 1 beta Rattus norvegicus 70-78 29199028-10 2018 An increase in IL-1beta, IL-6 and TNF was observed in females following intra-PAG morphine or M6G. phenylacetylglycine 78-81 interleukin 1 beta Rattus norvegicus 15-23 29397336-9 2018 The protection afforded by artesunate was evident from the histoarchitecture of stomach tissue and marked reduction in tissue expression of IL-1beta, IL-6, NF-kappaB(p65) and COX-2. Artesunate 27-37 interleukin 1 beta Rattus norvegicus 140-148 29199028-10 2018 An increase in IL-1beta, IL-6 and TNF was observed in females following intra-PAG morphine or M6G. Morphine 82-90 interleukin 1 beta Rattus norvegicus 15-23 29199028-11 2018 In males, only IL-1beta levels increased following morphine. Morphine 51-59 interleukin 1 beta Rattus norvegicus 15-23 29212295-3 2018 In aged rats, the oral administration of BPE (200 mg kg-1 day-1) for 8 weeks significantly reduced the mRNA and protein expression of interleukin-1beta, nuclear factor-kappa B, matrix metalloproteinase (MMP)-2, and MMP-8 in gingival tissues (p < 0.01). 1,2-bis(4-pyridyl)ethene 41-44 interleukin 1 beta Rattus norvegicus 134-175 29065194-7 2018 Results: We found that nicotine markedly attenuated the POCD and reduced the elevated levels of inflammatory cytokines in the serum, including IL-1beta and high mobility group box-1 (HMGB1), on postoperative day 1. Nicotine 23-31 interleukin 1 beta Rattus norvegicus 143-151 29628771-5 2018 Results: Compared with normal rats, STZ-diabetic rats displayed obvious mechanical allodynia and the increased expression of P2Y13 receptor, Iba-1, IL-1beta, and IL-6 in the dorsal spinal cord that was continued for 6 weeks in DNP rats. Streptozocin 36-39 interleukin 1 beta Rattus norvegicus 148-156 29628771-12 2018 A possible mechanism involved in MRS2211-induced analgesia is that blocking the P2Y13 receptor downregulates levels of IL-1beta and IL-6, which subsequently inhibit the activation of the JAK2/STAT3 signaling pathway. MRS 2211 33-40 interleukin 1 beta Rattus norvegicus 119-127 29606872-11 2018 Moreover, compared with MPS group, Se@SiO2 could increase collagen II and aggrecan, and reduce the IL-1beta level in the cartilage of femoral head. Selenium 35-37 interleukin 1 beta Rattus norvegicus 99-107 29606872-11 2018 Moreover, compared with MPS group, Se@SiO2 could increase collagen II and aggrecan, and reduce the IL-1beta level in the cartilage of femoral head. Silicon Dioxide 38-42 interleukin 1 beta Rattus norvegicus 99-107 29593572-5 2018 ZnO-NPs induced significant increases in the serum levels of interleukin 8 (IL-8), interleukin-1 beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha), and elevated the number of cells and the percentage of neutrophils in the blood. Zinc Oxide 0-3 interleukin 1 beta Rattus norvegicus 83-101 29593572-5 2018 ZnO-NPs induced significant increases in the serum levels of interleukin 8 (IL-8), interleukin-1 beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha), and elevated the number of cells and the percentage of neutrophils in the blood. Zinc Oxide 0-3 interleukin 1 beta Rattus norvegicus 103-111 29167166-3 2018 In urethane-anesthetized male Sprague-Dawley rats, intravenous injection of IL-1beta (500 ng) increased blood pressure, heart rate, renal sympathetic nerve activity, and mRNA for angiotensin-converting enzyme, angiotensin II type 1a receptor, cyclooxygenase-2, tumor necrosis factor-alpha, and IL-1beta, as well as the tumor necrosis factor-alpha p55 receptor and the IL-1 receptor, in the SFO and PVN. Urethane 3-11 interleukin 1 beta Rattus norvegicus 76-84 29536186-7 2018 METHODS: In vivo ALI model was simulated through intra-tracheal instillation of IL-1beta solution (100 mug/mL in PBS, pH 7.2, 200 muL) in male Sprague-Dawley rats. Lead 113-116 interleukin 1 beta Rattus norvegicus 80-88 29928672-6 2018 Propranolol, a beta-blocker, markedly ameliorated the inflammatory response and IL1beta overexpression by mitigating against epigenetic modifications. Propranolol 0-11 interleukin 1 beta Rattus norvegicus 80-87 29510478-6 2018 On the other hand, THSG inhibited PGE2 production and iNOS and matrix metalloproteinase-13 expressions by interleukin-1beta-stimulated primary rat chondrocytes. 2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside 19-23 interleukin 1 beta Rattus norvegicus 106-123 30302330-13 2018 Marked increase in the levels of serum amylase, lipase, caspase-1, IL-18 and IL-1beta were observed in ethanol and cerulein administered rats than in MEMARB co-administered rats. Ethanol 103-110 interleukin 1 beta Rattus norvegicus 77-85 29065194-8 2018 Additionally, nicotine suppressed the surgery-induced release of IL-1beta, TNF-alpha, HMGB1, and NF-kappaB p65 in the hippocampus on postoperative day 1 and day 3. Nicotine 14-22 interleukin 1 beta Rattus norvegicus 65-73 28365975-3 2018 We found that treatment with 20 mg/kg DXT could attenuate the neuronal damage, the reduction of phosphorylations of mTOR and p70S6K as well as the elevations of TNF-alpha and IL-1beta levels in the hippocampal CA1 region at 28 days following CCH. Duloxetine Hydrochloride 38-41 interleukin 1 beta Rattus norvegicus 175-183 29203367-11 2018 NaHS increased Nrf-2, EGFr, VEGFA and decreased pro-inflammatory markers expression and IL-1beta, IL-2, IL-13, TNF-alpha, GM-CSF plasma concentration. sodium bisulfide 0-4 interleukin 1 beta Rattus norvegicus 88-96 28488010-9 2018 Furthermore, the pretreatment with OSC (0.8, 2, or 5 micromol/L) significantly down-regulated expressions of IL-1beta, TNF-alpha, p-ERK1/2, p-JNK1/2, and p-p38 MAPK in neonatal rat primary-cultured hippocampal neurons induced by OGD/R injury. oxysophocarpine 35-38 interleukin 1 beta Rattus norvegicus 109-117 29331761-7 2018 In addition, WFA reduced the ROS generation, mitochondrial depolarization and apoptosis induced by inflammatory cytokines IL-1beta and TNF-alpha. withaferin A 13-16 interleukin 1 beta Rattus norvegicus 122-130 29331761-7 2018 In addition, WFA reduced the ROS generation, mitochondrial depolarization and apoptosis induced by inflammatory cytokines IL-1beta and TNF-alpha. ros 29-32 interleukin 1 beta Rattus norvegicus 122-130 28401316-7 2018 The results of enzyme-linked immunosorbent assay (ELISA) showed that perampanel significantly decreased the expression of pro-inflammatory cytokines IL-1beta and TNF-alpha, whereas it increased the levels of anti-inflammatory cytokines IL-10 and TGF-beta1 after MCAO. perampanel 69-79 interleukin 1 beta Rattus norvegicus 149-157 29307658-7 2018 The results showed that 2 Hz EA stimulation significantly improved the expression of alpha7nAChR and reduced the production of IL-1beta and CD11b in the spinal cord of rats with SNI-induced neuropathic pain, along with the relief of mechanical hypersensitivity after EA treatment. sni 178-181 interleukin 1 beta Rattus norvegicus 127-135 29467841-9 2018 MFA treatment markedly inhibited the expression of inflammatory factors TNF-alpha and IL-1beta. mfa 0-3 interleukin 1 beta Rattus norvegicus 86-94 29541166-12 2018 Its protection mechanism may be realized through decreasing the increased p38 and IL-1beta expression levels induced by desflurane, thus blocking the p38 mitogen-activated protein kinase (p38 MAPK) pathway. Desflurane 120-130 interleukin 1 beta Rattus norvegicus 82-90 29226500-6 2018 RESULTS: We found that the co-administration of propranolol with carrageenan in the TMJ of female rats significantly reduced several parameters of the inflammatory response induced by carrageenan such as plasma extravasation, neutrophil migration and the release of the pro-inflammatory cytokines TNF-alpha, IL-1beta and CINC-1. Propranolol 48-59 interleukin 1 beta Rattus norvegicus 308-316 29226500-6 2018 RESULTS: We found that the co-administration of propranolol with carrageenan in the TMJ of female rats significantly reduced several parameters of the inflammatory response induced by carrageenan such as plasma extravasation, neutrophil migration and the release of the pro-inflammatory cytokines TNF-alpha, IL-1beta and CINC-1. Carrageenan 65-76 interleukin 1 beta Rattus norvegicus 308-316 29214554-0 2018 Geniposide Suppresses Interleukin-1beta-Induced Inflammation and Apoptosis in Rat Chondrocytes via the PI3K/Akt/NF-kappaB Signaling Pathway. geniposide 0-10 interleukin 1 beta Rattus norvegicus 22-39 29188498-6 2018 The elevated concentration of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and IL-6 in MI rats was effectively reversed by the Umb administration. 7-hydroxycoumarin 185-188 interleukin 1 beta Rattus norvegicus 102-120 29188498-6 2018 The elevated concentration of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and IL-6 in MI rats was effectively reversed by the Umb administration. 7-hydroxycoumarin 185-188 interleukin 1 beta Rattus norvegicus 122-130 29414666-6 2018 In vitro studies using alveolar NR8383 macrophages with KC-characteristic gene expression further demonstrated that DEX not only repressed the pro-inflammatory cytokine production including with respect to interleukin (IL)-1beta and IL-6, but also enhanced gene expression of TAK1 and a phagocytic marker, natural-resistance-associated macrophage protein 1, under PBE-mimicked cholestatic conditions. Dexamethasone 116-119 interleukin 1 beta Rattus norvegicus 206-228 29243030-6 2018 Moreover, SA could also suppress the IL-1beta-induced expression of matrix metalloproteinase (MMP)-1, MMP-3, MMP-13, and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) in chondrocytes. sinapinic acid 10-12 interleukin 1 beta Rattus norvegicus 37-45 29243030-7 2018 Furthermore, our data found that SA could suppress the IL-1beta-induced mitogen-activated protein kinase (MAPK) pathway activation. sinapinic acid 33-35 interleukin 1 beta Rattus norvegicus 55-63 29243030-8 2018 In general, this paper elucidates that sinapic acid inhibits the IL-1beta-induced inflammation via MAPK pathways and may be a good agent for the treatment of OA. sinapinic acid 39-51 interleukin 1 beta Rattus norvegicus 65-73 29243030-0 2018 Sinapic Acid Inhibits the IL-1beta-Induced Inflammation via MAPK Downregulation in Rat Chondrocytes. sinapinic acid 0-12 interleukin 1 beta Rattus norvegicus 26-34 29243030-3 2018 To explore its potential therapeutic role for OA, rat chondrocytes were treated with IL-1beta (10 ng/ml) with different concentrations of SA in vitro. sinapinic acid 138-140 interleukin 1 beta Rattus norvegicus 85-93 29243030-4 2018 Our study revealed that SA could inhibit the IL-1beta-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2). sinapinic acid 24-26 interleukin 1 beta Rattus norvegicus 45-53 29243030-4 2018 Our study revealed that SA could inhibit the IL-1beta-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2). Nitric Oxide 76-88 interleukin 1 beta Rattus norvegicus 45-53 29243030-4 2018 Our study revealed that SA could inhibit the IL-1beta-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2). Dinoprostone 98-114 interleukin 1 beta Rattus norvegicus 45-53 29243030-4 2018 Our study revealed that SA could inhibit the IL-1beta-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2). Dinoprostone 116-120 interleukin 1 beta Rattus norvegicus 45-53 29414667-7 2018 Besides, fraxetin alleviated lipid peroxidation, enhanced hepatic antioxidant capabilities, inhibited CYP2E1 activity, and reduced the inflammatory mediators, including TNF-alpha and IL-1beta via up-regulation of hemeoxygenase-1 (HO-1) protein. fraxetin 9-17 interleukin 1 beta Rattus norvegicus 183-191 29257323-6 2018 The authors identified that oxyresveratrol significantly reversed the SCI-induced inhibition of Basso, Beattie, and Bresnahan scores, inhibited the SCI-mediated increase in spinal cord water content, significantly suppressed SCI-induced nuclear factor-kappaB/p65, tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 activities and reversed the malondialdehyde, superoxide dismutase, glutathione (GSH) and GSH peroxidase activities in SCI rats. puag-haad 28-42 interleukin 1 beta Rattus norvegicus 293-315 29314607-3 2018 Here, we demonstrated that high glucose (HG) induced the collagen synthesis by activation of the NLRP3 inflammasome, leading to caspase-1 activation, interleukin-1beta (IL-1beta) and IL-18 secretion in neonatal rat cardiac fibroblasts. Glucose 32-39 interleukin 1 beta Rattus norvegicus 150-167 29565745-1 2018 This study aimed to evaluate the role of eplerenone on the modulation of interleukin (IL)-1beta and IL-33/sST2 signaling pathway in an experimental model of left ventricular (LV) systolic dysfunction after acute myocardial infarction (MI). Eplerenone 41-51 interleukin 1 beta Rattus norvegicus 73-95 29565745-8 2018 Eplerenone reduced levels of sST2 and IL-1beta significantly. Eplerenone 0-10 interleukin 1 beta Rattus norvegicus 38-46 29565745-11 2018 Eplerenone could improve LV function by reducing expression of IL-1beta and sST2. Eplerenone 0-10 interleukin 1 beta Rattus norvegicus 63-71 29154988-7 2018 Myricetin significantly alleviated I/R-induced rat intestinal injury by reducing the generation of pro-inflammatory cytokines including TNF-alpha, IL-1beta, and IL-6 and by reducing MPO activity. myricetin 0-9 interleukin 1 beta Rattus norvegicus 147-155 29428576-7 2018 Simultaneously, GM1 administration also counteracted the enhanced inflammation in HH-exposed rats by muting pro-inflammatory cytokines IL-1beta, TNF-alpha, and IL-6 levels in serum and brain tissues. G(M1) Ganglioside 16-19 interleukin 1 beta Rattus norvegicus 135-143 29520237-10 2018 The results showed that central administration of hypertonic saline in SD rats significantly increased the expression of PICs including TNF-alpha, IL-6, and IL-1beta, as well as neuronal activation marker Fra1, compared to isotonic NaCl controls and osmolarity controls. Sodium Chloride 61-67 interleukin 1 beta Rattus norvegicus 157-165 29681766-11 2018 Also, paclitaxel treatment increased the expression levels of TNF-alpha and IL-1beta in the hippocampus tissue. Paclitaxel 6-16 interleukin 1 beta Rattus norvegicus 76-84 29973026-33 2018 At PIH 24, the mRNA expressions of IL-1beta, IL-18, NLRP3, and caspase-1 in lung tissue of rats in group SB were 5.0+-0.4, 3.32+-0.21, 3.54+-0.42, and 6.3+-1.0, respectively, significantly higher than 1.0, 1.00, 1.00, and 1.0 of group C (t=13.97, 14.14, 11.78, 7.13, P<0.01). Antimony 105-107 interleukin 1 beta Rattus norvegicus 35-43 29766025-0 2018 Isoliquiritigenin Inhibits IL-1beta-Induced Production of Matrix Metalloproteinase in Articular Chondrocytes. isoliquiritigenin 0-17 interleukin 1 beta Rattus norvegicus 27-35 29179648-15 2018 In females, but not males, hippocampal IL-6 content increased post-CCI compared with sham-injured controls, whereas IL-1beta content was augmented by minocycline. Minocycline 150-161 interleukin 1 beta Rattus norvegicus 116-124 29766025-3 2018 In this study, the effect of isoliquiritigenin on IL-1beta-induced production of matrix metalloproteinase and nuclear factor kappaB (NF-kappaB) activation was analyzed. isoliquiritigenin 29-46 interleukin 1 beta Rattus norvegicus 50-58 29766025-9 2018 Injecting isoliquiritigenin into rat knee joint also inhibited IL-1beta-induced NF-kappaB activation and MMPs production in articular cartilage. isoliquiritigenin 10-27 interleukin 1 beta Rattus norvegicus 63-71 29766025-8 2018 A 10-muM isoliquiritigenin treatment significantly inhibited IL-1beta-induced NF-kappaB activation and these MMPs production on chondrocytes. isoliquiritigenin 9-26 interleukin 1 beta Rattus norvegicus 61-69 29766025-10 2018 Isoliquiritigenin treatment inhibited IL-1beta-induced MMPs production and NF-kappaB activation both in vitro and in vivo, suggesting a potential therapeutic role of isoliquiritigenin to treat osteoarthritis. isoliquiritigenin 0-17 interleukin 1 beta Rattus norvegicus 38-46 29415719-7 2018 RESULTS: The results obtained showed that when compared with the morphine tolerance group, there was an increase in miR-365 expression and a decrease in the beta-arrestin2, ERK, CREB protein expressions, contents of IL-1beta, TNF-alpha, IL-18 and GFAP expression in the miR-365 mimic group, while the miR-365 inhibitor group displayed an opposite trend. Morphine 65-73 interleukin 1 beta Rattus norvegicus 216-224 29766025-10 2018 Isoliquiritigenin treatment inhibited IL-1beta-induced MMPs production and NF-kappaB activation both in vitro and in vivo, suggesting a potential therapeutic role of isoliquiritigenin to treat osteoarthritis. isoliquiritigenin 166-183 interleukin 1 beta Rattus norvegicus 38-46 29289839-9 2018 Furthermore, ZJPE also alleviated the retinal electrophysiology changes and impaired morphology of the retina and lowered the high levels of TNF-alpha, IL-1beta, ICAM-1, VEGF, AGEs, and AR in the retina. zjpe 13-17 interleukin 1 beta Rattus norvegicus 152-160 29120821-9 2018 In comparison with other formulations, Min(+)-MC-C induced the suppression of the expression of pro-inflammatory proteins TNF-alpha and IL-1beta in the articular knee joint, which resulted in the amelioration of RA. min(+)-mc-c 39-50 interleukin 1 beta Rattus norvegicus 136-144 29278855-6 2018 Fluoxetine administration significantly increased circulating ALT, AST, ALP and the pro-inflammatory cytokines TNF-alpha and IL-1beta levels in rats. Fluoxetine 0-10 interleukin 1 beta Rattus norvegicus 125-133 28871498-13 2018 Elevated TNF-alpha, nitric oxide (NO) and cytokines-IL-6 and IL-1beta with upregulated NF-kappaB/TNF-alpha/iNOS signalling pathways were effectively down-regulated by tangeretin. Nitric Oxide 20-32 interleukin 1 beta Rattus norvegicus 61-69 28988395-9 2018 The protection afforded by roxithromycin was substantiated by dose-dependent increase in mucus content, normalization of markers of oxidative stress (GSH and TBARS) and levels of TNF-alpha, PGE2 and nitrite along with marked decrease in expression of NFkappaB (p65), IL-1beta and COX-2. Roxithromycin 27-40 interleukin 1 beta Rattus norvegicus 267-275 29455725-6 2018 We demonstrated that external use of escin showed significant anti-inflammatory effects on acute and chronic inflammation in different animal models and its anti-inflammatory effects might be related to down-regulation of PGE2, TNF-alpha, and IL-1beta. Escin 37-42 interleukin 1 beta Rattus norvegicus 243-251 29022140-4 2018 Treatment with simvastatin demonstrated significant decreases in the concentration of protein, TNF-alpha, IL-1beta, IL-6, and lipocalin 2, and the number of polymorphonuclear neutrophils in bronchoalveolar lavage fluid in septic rats. Simvastatin 15-26 interleukin 1 beta Rattus norvegicus 106-114 29315967-7 2018 Curcumin also attenuated activities of Caspase-3, cyclooxygenase-2, inducible nitric oxide synthase, and levels of nuclear factor kappa-B, tumor necrosis factor-alpha, and interleukin-1beta, and cardiac tissue damages that were induced by DXR. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 172-189 29095793-3 2018 Our results from the in vivo experiments showed that low-dose (<=50 mg/kg) chronic SA administration suppressed serum endothelin 1 (ET-1) and interleukin-1beta (IL-1beta) contents, pyroptotic death of bone marrow-derived macrophages, and the expression of pyroptotic proteins ASC, NRLP3, and caspase-1. sinapinic acid 86-88 interleukin 1 beta Rattus norvegicus 145-162 29241031-8 2018 DEX effectively attenuated pulmonary pathology, and ameliorated the levels of MPO, SOD, MDA, GSH-Px, TNF-alpha, IL-6, IL-1beta and NO in LPS-stimulated rats and BEAS-2B cells. Dexmedetomidine 0-3 interleukin 1 beta Rattus norvegicus 118-126 29095793-3 2018 Our results from the in vivo experiments showed that low-dose (<=50 mg/kg) chronic SA administration suppressed serum endothelin 1 (ET-1) and interleukin-1beta (IL-1beta) contents, pyroptotic death of bone marrow-derived macrophages, and the expression of pyroptotic proteins ASC, NRLP3, and caspase-1. sinapinic acid 86-88 interleukin 1 beta Rattus norvegicus 164-172 29273374-11 2018 GSH also decreased H2O2-mediated increases in interleukin 1 beta secretion, cleaved caspase-3 activation, and apoptosis in IEC-6 cells. Glutathione 0-3 interleukin 1 beta Rattus norvegicus 46-64 29273374-11 2018 GSH also decreased H2O2-mediated increases in interleukin 1 beta secretion, cleaved caspase-3 activation, and apoptosis in IEC-6 cells. Hydrogen Peroxide 19-23 interleukin 1 beta Rattus norvegicus 46-64 29207198-6 2018 The results revealed that, following intervention with triptolide, inflammation was suppressed, and the mRNA expression levels of TNF-alpha, IL-1beta and IL-6 were reduced. triptolide 55-65 interleukin 1 beta Rattus norvegicus 141-149 29257269-0 2018 Protective effects of psoralidin on IL-1beta-induced chondrocyte apoptosis. psoralidin 22-32 interleukin 1 beta Rattus norvegicus 36-44 29257250-10 2018 Furthermore, myricetin reduced the expression levels of IL-1beta, IL-6, TNF-alpha, and MDA, and increased GSH/GSSG ratio and SOD activity. myricetin 13-22 interleukin 1 beta Rattus norvegicus 56-64 29257269-2 2018 The present study aimed to investigate the protective effects of psoralidin on interleukin (IL)-1beta-induced chondrocyte apoptosis and explore the underlying mechanisms. psoralidin 65-75 interleukin 1 beta Rattus norvegicus 79-101 29257269-8 2018 The results of the present study demonstrated that psoralidin may reduce IL-1beta-induced chondrocyte apoptosis. psoralidin 51-61 interleukin 1 beta Rattus norvegicus 73-81 29257269-9 2018 Psoralidin pretreatment also reversed the inhibitory effects of IL-1beta on B-cell lymphoma 2 (Bcl-2) expression, and decreased the IL-1beta-induced expression of Bcl-2-associated X protein, matrix metalloproteinase (MMP)-1 and MMP-13. psoralidin 0-10 interleukin 1 beta Rattus norvegicus 64-72 29257269-9 2018 Psoralidin pretreatment also reversed the inhibitory effects of IL-1beta on B-cell lymphoma 2 (Bcl-2) expression, and decreased the IL-1beta-induced expression of Bcl-2-associated X protein, matrix metalloproteinase (MMP)-1 and MMP-13. psoralidin 0-10 interleukin 1 beta Rattus norvegicus 132-140 29257269-10 2018 Furthermore, psoralidin decreased IL-1beta-induced caspase-3 and -9 activity, NO release, ROS production and nuclear factor (NF)-kappaB nuclear translocation. psoralidin 13-23 interleukin 1 beta Rattus norvegicus 34-42 29257269-10 2018 Furthermore, psoralidin decreased IL-1beta-induced caspase-3 and -9 activity, NO release, ROS production and nuclear factor (NF)-kappaB nuclear translocation. Reactive Oxygen Species 90-93 interleukin 1 beta Rattus norvegicus 34-42 29257269-11 2018 In addition, the NF-kappaB inhibitor pyrriolidine-dithiocarbamate exerted similar effects to psoralidin, thus suggesting that IL-1beta induced proapoptotic effects in rat chondrocytes via an NF-kappaB-dependent pathway. pyrriolidine-dithiocarbamate 37-65 interleukin 1 beta Rattus norvegicus 126-134 29257269-11 2018 In addition, the NF-kappaB inhibitor pyrriolidine-dithiocarbamate exerted similar effects to psoralidin, thus suggesting that IL-1beta induced proapoptotic effects in rat chondrocytes via an NF-kappaB-dependent pathway. psoralidin 93-103 interleukin 1 beta Rattus norvegicus 126-134 29257269-12 2018 Since psoralidin could protect chondrocytes from IL-1beta-induced apoptosis and MMP expression, the present results suggested that psoralidin may be considered a drug candidate for the treatment of osteoarthritis. psoralidin 6-16 interleukin 1 beta Rattus norvegicus 49-57 29257269-12 2018 Since psoralidin could protect chondrocytes from IL-1beta-induced apoptosis and MMP expression, the present results suggested that psoralidin may be considered a drug candidate for the treatment of osteoarthritis. psoralidin 131-141 interleukin 1 beta Rattus norvegicus 49-57 29079428-7 2018 Interestingly, gAcrp prevented the tunicamycin-induced activation of the inflammasome, a key platform involved in the production of inflammatory cytokines that induces pyroptosis, determined by suppression of interleukin-1beta (IL-1beta) maturation, apoptosis-associated speck-like protein containing a carboxy-terminal CARD (ASC) speck formation, and caspase-1 activation. gacrp 15-20 interleukin 1 beta Rattus norvegicus 209-226 29303910-6 2018 RESULTS: Severe acute pancreatitis resulted in significantly higher serum IL-18 and IL-1beta concentration, higher mRNA expression, and protein levels of NOD1, NOD2, and NLRP3 in intestine in SAP treated with saline groups compared with sham operation groups. Sodium Chloride 209-215 interleukin 1 beta Rattus norvegicus 84-92 29133079-13 2018 The levels of apoptotic (Bax/Bcl-2 ratio and cleaved caspase-3) and inflammatory (IL-6, TNF-alpha, and IL-1beta) biomarkers in lung tissue were lower in baicalein-treated groups. baicalein 153-162 interleukin 1 beta Rattus norvegicus 103-111 29207058-5 2018 In addition, treatment with baicalin decreased tumor necrosis factor-alpha, interleukin (IL)-8, IL-1beta and IL-18 concentrations in the serum, reduced myeloperoxidase activity and malondialdehyde content, and increased the level of superoxide dismutase in the serum in treated model rats with ALI. baicalin 28-36 interleukin 1 beta Rattus norvegicus 96-104 29128398-7 2018 Next, we optimized the sequence and modification of the iNOS sense oligonucleotides in interleukin 1beta-treated rat hepatocytes. Oligonucleotides 67-83 interleukin 1 beta Rattus norvegicus 87-104 29422835-11 2017 The nanoparticle-encapsulated curcumin decreased up-regulated IL-1beta and Cx43 expression and reduced levels of phosphorylated-Akt (p-Akt) in the DRG of rats with DM. Curcumin 30-38 interleukin 1 beta Rattus norvegicus 62-70 29079428-7 2018 Interestingly, gAcrp prevented the tunicamycin-induced activation of the inflammasome, a key platform involved in the production of inflammatory cytokines that induces pyroptosis, determined by suppression of interleukin-1beta (IL-1beta) maturation, apoptosis-associated speck-like protein containing a carboxy-terminal CARD (ASC) speck formation, and caspase-1 activation. gacrp 15-20 interleukin 1 beta Rattus norvegicus 228-236 29079428-7 2018 Interestingly, gAcrp prevented the tunicamycin-induced activation of the inflammasome, a key platform involved in the production of inflammatory cytokines that induces pyroptosis, determined by suppression of interleukin-1beta (IL-1beta) maturation, apoptosis-associated speck-like protein containing a carboxy-terminal CARD (ASC) speck formation, and caspase-1 activation. Tunicamycin 35-46 interleukin 1 beta Rattus norvegicus 209-226 29079428-7 2018 Interestingly, gAcrp prevented the tunicamycin-induced activation of the inflammasome, a key platform involved in the production of inflammatory cytokines that induces pyroptosis, determined by suppression of interleukin-1beta (IL-1beta) maturation, apoptosis-associated speck-like protein containing a carboxy-terminal CARD (ASC) speck formation, and caspase-1 activation. Tunicamycin 35-46 interleukin 1 beta Rattus norvegicus 228-236 29352206-4 2018 Acute treatment with the OM-3 fatty acid docosahexaenoic acid suppressed MSU-, cholesterol crystal-, and calcium pyrophosphate crystal-mediated interleukin-1beta (IL-1beta) production in vitro. Fatty Acids, Omega-3 25-40 interleukin 1 beta Rattus norvegicus 144-161 29352206-4 2018 Acute treatment with the OM-3 fatty acid docosahexaenoic acid suppressed MSU-, cholesterol crystal-, and calcium pyrophosphate crystal-mediated interleukin-1beta (IL-1beta) production in vitro. Fatty Acids, Omega-3 25-40 interleukin 1 beta Rattus norvegicus 163-171 29352206-4 2018 Acute treatment with the OM-3 fatty acid docosahexaenoic acid suppressed MSU-, cholesterol crystal-, and calcium pyrophosphate crystal-mediated interleukin-1beta (IL-1beta) production in vitro. Docosahexaenoic Acids 41-61 interleukin 1 beta Rattus norvegicus 144-161 29352206-4 2018 Acute treatment with the OM-3 fatty acid docosahexaenoic acid suppressed MSU-, cholesterol crystal-, and calcium pyrophosphate crystal-mediated interleukin-1beta (IL-1beta) production in vitro. Docosahexaenoic Acids 41-61 interleukin 1 beta Rattus norvegicus 163-171 29352206-4 2018 Acute treatment with the OM-3 fatty acid docosahexaenoic acid suppressed MSU-, cholesterol crystal-, and calcium pyrophosphate crystal-mediated interleukin-1beta (IL-1beta) production in vitro. Cholesterol 79-90 interleukin 1 beta Rattus norvegicus 163-171 29352206-4 2018 Acute treatment with the OM-3 fatty acid docosahexaenoic acid suppressed MSU-, cholesterol crystal-, and calcium pyrophosphate crystal-mediated interleukin-1beta (IL-1beta) production in vitro. Calcium Pyrophosphate 105-126 interleukin 1 beta Rattus norvegicus 144-161 29352206-4 2018 Acute treatment with the OM-3 fatty acid docosahexaenoic acid suppressed MSU-, cholesterol crystal-, and calcium pyrophosphate crystal-mediated interleukin-1beta (IL-1beta) production in vitro. Calcium Pyrophosphate 105-126 interleukin 1 beta Rattus norvegicus 163-171 29352206-7 2018 Additionally, in complex formulations of OM-3 fatty acids, high levels of palmitic acid could reduce the in vivo effect on crystal-mediated IL-1beta elevation. Fatty Acids, Omega-3 41-57 interleukin 1 beta Rattus norvegicus 140-148 29352206-7 2018 Additionally, in complex formulations of OM-3 fatty acids, high levels of palmitic acid could reduce the in vivo effect on crystal-mediated IL-1beta elevation. Palmitic Acid 74-87 interleukin 1 beta Rattus norvegicus 140-148 29398906-11 2018 Expression of tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) in the DPN group was significantly increased compared with the control and T2DM groups (P<0.01). dpn 171-174 interleukin 1 beta Rattus norvegicus 55-73 29398906-11 2018 Expression of tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) in the DPN group was significantly increased compared with the control and T2DM groups (P<0.01). dpn 171-174 interleukin 1 beta Rattus norvegicus 75-83 29321061-10 2018 Cardiac inflammatory markers including tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) and caspase-3, an apoptotic marker, were also elevated in the DOX group. Doxorubicin 175-178 interleukin 1 beta Rattus norvegicus 83-101 29329251-3 2018 Briefly, DADS exerted an anti-inflammation effect on emphysema rats through decreasing cell influx in the bronchoalveolar lavage fluid (BALF) and suppressing pro-inflammation cytokine production including tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) via inhibiting the NF-kappaB pathway. diallyl disulfide 9-13 interleukin 1 beta Rattus norvegicus 246-263 29329251-3 2018 Briefly, DADS exerted an anti-inflammation effect on emphysema rats through decreasing cell influx in the bronchoalveolar lavage fluid (BALF) and suppressing pro-inflammation cytokine production including tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) via inhibiting the NF-kappaB pathway. diallyl disulfide 9-13 interleukin 1 beta Rattus norvegicus 265-273 29329279-11 2018 In addition, the increased expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) in serum, and myeloperoxidase (MPO) in myocardium were significantly suppressed by diosgenin administration. Diosgenin 195-204 interleukin 1 beta Rattus norvegicus 82-100 29329279-11 2018 In addition, the increased expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) in serum, and myeloperoxidase (MPO) in myocardium were significantly suppressed by diosgenin administration. Diosgenin 195-204 interleukin 1 beta Rattus norvegicus 102-110 29321061-10 2018 Cardiac inflammatory markers including tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) and caspase-3, an apoptotic marker, were also elevated in the DOX group. Doxorubicin 175-178 interleukin 1 beta Rattus norvegicus 103-111 29511679-6 2018 PGE1 pretreatment attenuated IR injury in extrahepatic cholestatic liver probably by suppressing MDA, MPO, TNF-alpha, IL-1beta, ICAM-1, and Bax levels and improving GSH and Bcl-2 levels. Alprostadil 0-4 interleukin 1 beta Rattus norvegicus 118-126 28917976-10 2018 In addition, upregulation of several inflammatory factors, such as ICAM-1 and IL-1beta in the gastrocnemius muscles of ischemic hindlimb were suppressed by LMWF administration. lmwf 156-160 interleukin 1 beta Rattus norvegicus 78-86 29304864-8 2018 In addition, Z-YVAD-FMK, a caspase-1 inhibitor, was used to treat BV-2 microglia to determine whether activation of NLRP3 inflammasome was required for the enhancing effect of hypercapnia on expressing IL-1beta by Western blotting or double immunofluorescence. benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone 13-23 interleukin 1 beta Rattus norvegicus 202-210 30357735-4 2018 In addition, CIH increases the CB levels of proinflammatory cytokines IL-1beta, IL-6 and TNF-alpha in the CB. cih 13-16 interleukin 1 beta Rattus norvegicus 70-78 30357735-10 2018 In addition, a significant increase of IL-1beta, IL-6 and TNF-alpha immunofluorescence was found in the NTS at day 28 of CIH exposure compared with control rats. cih 121-124 interleukin 1 beta Rattus norvegicus 39-47 29135586-11 2018 The fentanyl or surgical incision upregulated the expression of IL-1beta, IL-6, and TNF-alpha in the spinal cord and bilateral DRG for more than 7 days and increase of ionized calcium-binding adapter molecule 1 in the spinal cord. Fentanyl 4-12 interleukin 1 beta Rattus norvegicus 64-72 29135586-12 2018 The combination of fentanyl and incision resulted in higher increase of IL-1beta, IL-6, and TNF-alpha in the spinal cord and bilateral DRG. Fentanyl 19-27 interleukin 1 beta Rattus norvegicus 72-80 29135586-13 2018 CONCLUSIONS: The surgical plantar incision with or without perioperative fentanyl induced significant mechanical and thermal hyperalgesia, an increased expression of IL-1beta, IL-6, TNF-alpha in the spinal cord and DRG, and activation of microglia in the spinal cord. Fentanyl 73-81 interleukin 1 beta Rattus norvegicus 166-174 29080744-9 2018 DEX reduced seizure severity and increased the amplitudes and sustainable time of LTP, and also inhibited the hippocampal expression of alpha7-nAChR and IL-1beta in CSE rats. Dexmedetomidine 0-3 interleukin 1 beta Rattus norvegicus 153-161 30306802-8 2018 Moreover, Cel-Indo-NLCs showed prominent effect of decreasing paw oedema, inhibiting inflammation and pain by regulating the levels of IL-1beta, TNF-alpha, beta-endorphin and Substance P. After the administration of Cel-Indo-NLCs-gel, no skin irritation was observed in rats. cel-indo 10-18 interleukin 1 beta Rattus norvegicus 135-143 28986307-8 2018 Dual luciferase and gel-shift assays and chromatin immunoprecipitation-polymerase chain reaction demonstrated that IL-1beta and TNF-alpha enhanced ASIC1a promoter activity in chondrocytes by increasing NF-kappaB DNA-binding activities, which was in turn prevented by the NF-kappaB inhibitor ammonium pyrrolidinedithiocarbamate. pyrrolidine dithiocarbamic acid 291-326 interleukin 1 beta Rattus norvegicus 115-123 28986307-9 2018 IL-1beta and TNF-alpha also decreased cell viability but enhanced LDH release, intracellular Ca2+ concentration elevation, loss of mitochondrial membrane potential, cleaved PARP and cleaved caspase-3/9 expression, and apoptosis in acid-stimulated chondrocytes, which effects could be abrogated by the specific ASIC1a inhibitor psalmotoxin-1 (PcTX-1), ASIC1a-short hairpin RNA or calcium chelating agent BAPTA-AM. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 403-411 interleukin 1 beta Rattus norvegicus 0-8 29553845-5 2018 After induction CIA rats were treated with AuNGs in phosphate buffer at a dose of 20 mug/kg body weight for 20 days and found a significant decrease in the level of inflammatory mediators like TNF-alpha, IL-1beta, COX-2 and transcription factor NF-kB (Nuclear factor-kB), which was found to be elevated in CIA rats. Phosphates 52-61 interleukin 1 beta Rattus norvegicus 204-212 28561324-7 2018 Curcumin further reduced adenine-induced hypertension, urinary albumin, the inflammatory cytokines IL-1beta, IL-6 and TNF-alpha, cystatin C and adiponectin. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 99-107 29080744-10 2018 DEX treatment decreased serum IL-1beta, TNF-alpha and S-100beta levels and increased BDNF levels. Dexmedetomidine 0-3 interleukin 1 beta Rattus norvegicus 30-38 29091898-7 2018 Furthermore, dioscin obviously down-regulated the expression levels of NF-kappaB (p65), ICAM-1, HMGB1, COX-2, TNF-alpha, IL-1beta and IL-6. dioscin 13-20 interleukin 1 beta Rattus norvegicus 121-129 29996116-8 2018 Furthermore, alpha-LA induced the polarization of microglia to the M2 phenotype, modulated the expression of IL-1beta, IL-6, TNF-alpha and IL-10, and attenuated the activation of NF-kappaB after MCAO. Thioctic Acid 13-21 interleukin 1 beta Rattus norvegicus 109-117 29101808-0 2018 Gastrodin reduces IL-1beta-induced apoptosis, inflammation, and matrix catabolism in osteoarthritis chondrocytes and attenuates rat cartilage degeneration in vivo. gastrodin 0-9 interleukin 1 beta Rattus norvegicus 18-26 29101808-5 2018 Our results showed that gastrodin could prevent chondrocyte apoptosis induced by IL-1beta. gastrodin 24-33 interleukin 1 beta Rattus norvegicus 81-89 29101808-6 2018 Additionally, gastrodin suppressed the nuclear factor kappa B (NF-kappaB) pathway, decreased the release of inflammatory mediators (IL-6, TNF-alpha), and reduced matrix catabolism in IL-1beta-treated chondrocytes. gastrodin 14-23 interleukin 1 beta Rattus norvegicus 183-191 29378386-10 2018 STA significantly inhibited the expressions of inflammatory factors interleukin-6 (IL-6), IL-8, IL-1beta, tumor necrosis factor-alpha, inducible nitric oxide synthase and cyclooxygenase-2. stachydrine 0-3 interleukin 1 beta Rattus norvegicus 96-133 29091874-10 2018 RESULTS: These results demonstrated that AECF significantly inhibited nitrite production and inhibited the levels of iNOS, MMP-13, ADAMTS-4, and ADAMTS-5 in interleukin-1beta-induced rat primary cultured chondrocytes. aecf 41-45 interleukin 1 beta Rattus norvegicus 157-174 29091880-11 2018 The anti-hyperalgesic effects of diosmin were also linked with reduced levels of TNF-alpha, IL-1beta and IL-6. Diosmin 33-40 interleukin 1 beta Rattus norvegicus 92-100 29136765-5 2018 We showed that PQS treatment could protect chondrocytes against endoplasmic reticulum (ER) stress and associated apoptosis induced by interleukin (IL)-1beta. Panax quinquefolium saponin 15-18 interleukin 1 beta Rattus norvegicus 134-156 30160153-0 2018 Ethyl pyruvate prevents from chronic cerebral hypoperfusion via preserving cognitive function and decreasing oxidative stress, caspase 3 activation and IL-1beta level. ethyl pyruvate 0-14 interleukin 1 beta Rattus norvegicus 152-160 30160153-7 2018 RESULTS: Results showed that CCH caused a striking impairment of spatial working memory, accompanied with increased levels of MDA and IL-1beta as well as caspase 3 level. 1-acetyl-2-(coumariniminecarboxamide-3-yl)hydrazine 29-32 interleukin 1 beta Rattus norvegicus 134-142 30165357-14 2018 In addition, beta-elemene reduced the ELISA-detected secretion of interleukin (IL)-6 and IL-1beta. beta-elemene 13-25 interleukin 1 beta Rattus norvegicus 89-97 30261488-13 2018 RESULTS: Malondialdehyde level and myeloperoxidase and glutathione peroxidase, TNF-alpha, IL-1beta, and IL-6 levels group in intestinal tissue decreased significantly in the SalA pretreatment groups compared to the I/R group. salvianolic acid A 174-178 interleukin 1 beta Rattus norvegicus 90-98 30308489-12 2018 CONCLUSION: Overexpression of miR-136-5p promotes the generation of IL-1beta, IL-6, TNF-alpha, IFN-alpha, IKKbeta, and NF-kappaB in SCI rats but inhibits the expression of A20. mir-136-5p 30-40 interleukin 1 beta Rattus norvegicus 68-76 29843137-4 2018 In a group of healthy rats, induction of chronic muscle pain by intramuscular injection of 100 microL of acidic saline on days 0 and 5 resulted in peripheral sensitization (measured using the von Frey test) and significant (p < 0.05) increases in IL-1beta (160.2 +- 1.1 to 335.2 +- 1.8), IL-6 (100.1 +- 1.4 to 202.4 +- 1.1), and TNF-alpha (60.0 +- 0.7 to 115.5 +- 1). Sodium Chloride 112-118 interleukin 1 beta Rattus norvegicus 250-258 30062967-11 2018 Western blot showed that KA stimulation increased the expression of IL-1beta and NLRP3, which were reduced by curcumin treatment. Curcumin 110-118 interleukin 1 beta Rattus norvegicus 68-76 29879885-8 2018 RESULTS: Our data show that ranolazine intraperitoneally improved the impaired left ventricular function, and attenuated the exaggerated NE/BNP-45 and cytokines (such as IL-1beta, IL-6 and TNF-alpha) after development of CHF. Ranolazine 28-38 interleukin 1 beta Rattus norvegicus 170-178 29399112-5 2018 Notably, berberine significantly suppressed the levels of tumor necrosis factor, interleukin-1beta and monocyte chemoattractant protein-1, as well as reduced the protein expression levels of nuclear factor-kappaB, Bcl-2-associated X protein and cytochrome c in DAI rats. Berberine 9-18 interleukin 1 beta Rattus norvegicus 81-98 29274628-7 2018 NaHS also relieved the up-regulation of tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 in the medulla oblongata of the neonatal CSE rats. sodium bisulfide 0-4 interleukin 1 beta Rattus norvegicus 69-86 30703768-4 2018 Ob-jectives: In this study, we aimed to evaluate the anticatabolic effect of 40% prethanol extract of T. pratense (40% PeTP) on IL-1beta-stimulated chondrocytes. prethanol 81-90 interleukin 1 beta Rattus norvegicus 128-136 30703768-4 2018 Ob-jectives: In this study, we aimed to evaluate the anticatabolic effect of 40% prethanol extract of T. pratense (40% PeTP) on IL-1beta-stimulated chondrocytes. petp 119-123 interleukin 1 beta Rattus norvegicus 128-136 30703768-8 2018 RESULTS: PeTP (40%) significantly inhibited the IL-1beta-induced expression of nitrite, iNOS, PGE2, COX-2, MMP-1, MMP-3, MMP-13, and ADAMTS-4 in isolated primary rat chondrocytes. petp 9-13 interleukin 1 beta Rattus norvegicus 48-56 30703768-8 2018 RESULTS: PeTP (40%) significantly inhibited the IL-1beta-induced expression of nitrite, iNOS, PGE2, COX-2, MMP-1, MMP-3, MMP-13, and ADAMTS-4 in isolated primary rat chondrocytes. Nitrites 79-86 interleukin 1 beta Rattus norvegicus 48-56 30703768-8 2018 RESULTS: PeTP (40%) significantly inhibited the IL-1beta-induced expression of nitrite, iNOS, PGE2, COX-2, MMP-1, MMP-3, MMP-13, and ADAMTS-4 in isolated primary rat chondrocytes. Dinoprostone 94-98 interleukin 1 beta Rattus norvegicus 48-56 29399074-7 2018 D-Limonene markedly decreased the mRNA expression of interleukin-1beta, monocyte chemoattractant protein-1 and cyclooxygenase-2 in SHRsp rats following stroke. Limonene 0-10 interleukin 1 beta Rattus norvegicus 53-70 29434699-6 2018 Treatment with EGCG significantly reduced interleukin-1beta, interferon-gamma (INF-gamma) and tumor necrosis factor-alpha (TNF-alpha) levels in the AIT rats through suppression of nuclear factor-kappaB (NF-kappaB) pathway. epigallocatechin gallate 15-19 interleukin 1 beta Rattus norvegicus 42-59 29399101-7 2018 Vaccarin treatment attenuated hypertension, reduced fibrosis markers, NADPH oxidase (NOX)-2, NOX-4, 3-nitrotyrosine, tumor necrosis factor-alpha, interleukin 1beta (IL-1beta), and IL-6 protein levels and altered pro-apoptotic protein levels including caspase-3, anti-apoptosis protein B cell lymphoma (Bcl)-2 and Bcl-2 associated X, apoptosis regulator in the right kidney of 2K1C rats. vaccarin H 0-8 interleukin 1 beta Rattus norvegicus 146-163 29399101-7 2018 Vaccarin treatment attenuated hypertension, reduced fibrosis markers, NADPH oxidase (NOX)-2, NOX-4, 3-nitrotyrosine, tumor necrosis factor-alpha, interleukin 1beta (IL-1beta), and IL-6 protein levels and altered pro-apoptotic protein levels including caspase-3, anti-apoptosis protein B cell lymphoma (Bcl)-2 and Bcl-2 associated X, apoptosis regulator in the right kidney of 2K1C rats. vaccarin H 0-8 interleukin 1 beta Rattus norvegicus 165-173 28945000-8 2018 We found that RosA down-regulated the MMPs expression as well as nitric oxide and PGE2 production in IL-1beta-induced chondrocytes. Dinoprostone 82-86 interleukin 1 beta Rattus norvegicus 101-109 29861525-12 2018 Pretreatment with HEZA attenuated scopolamine-induced elevation of TNF-alpha, IL-1 beta, levels in hippocampus and reversed diminished IL-10 concentrations towards normal levels in the brain. heza 18-22 interleukin 1 beta Rattus norvegicus 78-87 29861525-12 2018 Pretreatment with HEZA attenuated scopolamine-induced elevation of TNF-alpha, IL-1 beta, levels in hippocampus and reversed diminished IL-10 concentrations towards normal levels in the brain. Scopolamine 34-45 interleukin 1 beta Rattus norvegicus 78-87 29348722-10 2018 Treatment with SPJ decreased the levels of interleukin-1beta and tumor necrosis factor-alpha, reduced the phosphorylation of three MAPK isoforms, and inhibited the expression of NF-kappaB in the colon of aging rats. (3R,3'R)-N~1~,N~1~'-butane-1,4-diyldibutane-1,3-diamine 15-18 interleukin 1 beta Rattus norvegicus 43-92 29078973-10 2018 The up-regulations of inflammation-related molecules (TNF-alpha, IL-1beta) in SAH rats were suppressed by glycyrrhizin treatment. Glycyrrhizic Acid 106-118 interleukin 1 beta Rattus norvegicus 65-73 31938086-8 2018 The results indicated that High glucose (30 mmol/L) significantly decreased the cell viability of cardiomyocytes after co-cultivated for 12 h and had a time-dependent manner, and increased IL-1beta, IL-6 and TNF-alpha secretion in cardiomyocytes. Glucose 32-39 interleukin 1 beta Rattus norvegicus 189-197 31938086-11 2018 After treatment with Res 20 mumol/L for 12 h, IL-1beta, IL-6 and TNF-alpha secretion were markedly decreased, and the phosphorylation of ERK1/2, p38 MAPK and NF-kappaB level were also decreased. resveratrol 21-24 interleukin 1 beta Rattus norvegicus 46-54 30587690-8 2018 At 10 muM, alpha-tocopherol increased the gene expression of IL-1beta, and markedly promoted that of TNF-alpha. alpha-Tocopherol 11-27 interleukin 1 beta Rattus norvegicus 61-69 29229114-3 2018 MATERIALS AND METHODS: We investigated the role of estradiol on the generation of interleukin (IL)-1beta, IL-10, vascular endothelial growth factor (VEGF), and cytokine-induced neutrophil chemoattractant 1 (CINC-1) in a female rat model of intestinal IR. Estradiol 51-60 interleukin 1 beta Rattus norvegicus 82-104 30606963-8 2018 The elevated serum concentrations of TNFalpha and IL-1beta by LPS in the AsA-deficient group decreased in groups fed AsA. Ascorbic Acid 73-76 interleukin 1 beta Rattus norvegicus 50-58 30606963-8 2018 The elevated serum concentrations of TNFalpha and IL-1beta by LPS in the AsA-deficient group decreased in groups fed AsA. Ascorbic Acid 117-120 interleukin 1 beta Rattus norvegicus 50-58 29229114-11 2018 In addition, 17beta-estradiol significantly prevented the ex-vivo release of IL-1beta and VEGF from lung tissue. Estradiol 13-29 interleukin 1 beta Rattus norvegicus 77-85 29302208-8 2018 We also observed that morroniside reduced the expression of IL-6, IL-1beta and TNF-alpha in myocardium. morroniside 22-33 interleukin 1 beta Rattus norvegicus 66-74 29913457-9 2018 Quantitative polymerase chain reaction analysis revealed that mRNA expression of NLRP3, caspase-1, ASC, and IL-1beta was remarkably increased in rat kidneys with doxorubicin nephropathy, and that this upregulation of the major components of the NLRP3 inflammasome was effectively suppressed by treatment with either sitagliptin or linagliptin. Doxorubicin 162-173 interleukin 1 beta Rattus norvegicus 108-116 29913457-9 2018 Quantitative polymerase chain reaction analysis revealed that mRNA expression of NLRP3, caspase-1, ASC, and IL-1beta was remarkably increased in rat kidneys with doxorubicin nephropathy, and that this upregulation of the major components of the NLRP3 inflammasome was effectively suppressed by treatment with either sitagliptin or linagliptin. Sitagliptin Phosphate 316-327 interleukin 1 beta Rattus norvegicus 108-116 29913457-9 2018 Quantitative polymerase chain reaction analysis revealed that mRNA expression of NLRP3, caspase-1, ASC, and IL-1beta was remarkably increased in rat kidneys with doxorubicin nephropathy, and that this upregulation of the major components of the NLRP3 inflammasome was effectively suppressed by treatment with either sitagliptin or linagliptin. Linagliptin 331-342 interleukin 1 beta Rattus norvegicus 108-116 29257210-5 2018 Treatment with tanshinone IIA effectively inhibited spastic cerebral palsy, and the activities of interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha, monocyte chemoattractant protein 1, cyclooxygenase-2 and prostaglandin E2 in a neonatal rat model of SCP. tanshinone 15-29 interleukin 1 beta Rattus norvegicus 98-120 29115625-8 2018 The production of proinflammatory cytokines was investigated using ELISA kits, and the results demonstrated that silymarin dose-dependently inhibited the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-10 and IL-1beta in the liver. Silymarin 113-122 interleukin 1 beta Rattus norvegicus 233-241 28866823-6 2018 Moreover, baicalein attenuated acrolein-induced caspase 1 activation (a pro-inflammatory caspase) and interleukin-1beta levels, indicating that baicalein prevented acrolein-induced inflammasome activation. baicalein 10-19 interleukin 1 beta Rattus norvegicus 102-119 28866823-6 2018 Moreover, baicalein attenuated acrolein-induced caspase 1 activation (a pro-inflammatory caspase) and interleukin-1beta levels, indicating that baicalein prevented acrolein-induced inflammasome activation. Acrolein 31-39 interleukin 1 beta Rattus norvegicus 102-119 28866823-6 2018 Moreover, baicalein attenuated acrolein-induced caspase 1 activation (a pro-inflammatory caspase) and interleukin-1beta levels, indicating that baicalein prevented acrolein-induced inflammasome activation. baicalein 144-153 interleukin 1 beta Rattus norvegicus 102-119 28866823-6 2018 Moreover, baicalein attenuated acrolein-induced caspase 1 activation (a pro-inflammatory caspase) and interleukin-1beta levels, indicating that baicalein prevented acrolein-induced inflammasome activation. Acrolein 164-172 interleukin 1 beta Rattus norvegicus 102-119 29138829-5 2018 Resveratrol inhibited tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and IL-18 expression levels, and decreased caspase-3/9 activity in rats with OA. Resveratrol 0-11 interleukin 1 beta Rattus norvegicus 51-73 29115481-6 2018 Sparstolonin B significantly inhibited the IVDD-induced inflammatory factors tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6, oxidative stress factors (malondialdehyde), and superoxide dismutase and caspase-3/9 activities. sparstolonin B 0-14 interleukin 1 beta Rattus norvegicus 106-128 29451216-10 2018 Curcumin and EGCG alone or in combination increased axonal sprouting, decreased glial scar formation, and altered the levels of macrophage inflammatory protein 1-alpha, interleukin-1beta, interleukin-4 and interleukin-6 cytokines. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 169-186 29623757-11 2018 Paclitaxel treatment also induced NF-kappaB(p65) activation and upregulation of proinflammatory factors (TNF-alpha, IL-1beta, and IL-6). Paclitaxel 0-10 interleukin 1 beta Rattus norvegicus 116-124 29900804-6 2018 Results IL-1beta, IL-6, and TNF-alpha were elevated within the periaqueductal gray of oxaliplatin rats. Oxaliplatin 86-97 interleukin 1 beta Rattus norvegicus 8-16 29900804-7 2018 Protein expression of IL-1beta, IL-6, and TNF-alpha receptors (namely, IL-1R, IL-6R, and TNFR subtype TNFR1) in the plasma membrane periaqueductal gray of oxaliplatin rats was upregulated, whereas the total expression of pro-inflammatory cytokine receptors was not altered. Oxaliplatin 155-166 interleukin 1 beta Rattus norvegicus 22-30 28697972-14 2018 Moreover, edaravone decreased the levels of NF-kappaB (P65) and proinflammatory cytokines TNF-alpha, IL-1beta and IL-6 and the inflammatory proteins expression levels, HMGB1, nNOS, iNOS and eNOS in the hippocampus. Edaravone 10-19 interleukin 1 beta Rattus norvegicus 101-109 29451216-10 2018 Curcumin and EGCG alone or in combination increased axonal sprouting, decreased glial scar formation, and altered the levels of macrophage inflammatory protein 1-alpha, interleukin-1beta, interleukin-4 and interleukin-6 cytokines. epigallocatechin gallate 13-17 interleukin 1 beta Rattus norvegicus 169-186 28666294-6 2018 Treatment of EGCG significantly reduced the expression of malondialdehyde, glial fibrillary acidic protein, tumor necrosis factor-alpha, and interleukin-1beta and increased glutathione level in the homocysteine-treated group. epigallocatechin gallate 13-17 interleukin 1 beta Rattus norvegicus 141-158 28666294-6 2018 Treatment of EGCG significantly reduced the expression of malondialdehyde, glial fibrillary acidic protein, tumor necrosis factor-alpha, and interleukin-1beta and increased glutathione level in the homocysteine-treated group. Homocysteine 198-210 interleukin 1 beta Rattus norvegicus 141-158 29032684-8 2017 In contrast, supplementation with 480 and 640 mg/L boron had the opposite effect on the above indicators in rats and elevated levels of pro-inflammatory cytokines, such as interleukin 6 (IL-6), interleukin 1beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha) (p < 0.05). Boron 51-56 interleukin 1 beta Rattus norvegicus 194-211 29379356-10 2018 The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group. Sevoflurane 83-94 interleukin 1 beta Rattus norvegicus 182-190 29379356-10 2018 The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group. Halothane 96-105 interleukin 1 beta Rattus norvegicus 182-190 29379356-10 2018 The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group. Sevoflurane 110-121 interleukin 1 beta Rattus norvegicus 182-190 29379356-10 2018 The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group. Halothane 124-133 interleukin 1 beta Rattus norvegicus 182-190 29379356-10 2018 The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group. Sevoflurane 110-121 interleukin 1 beta Rattus norvegicus 182-190 29379356-10 2018 The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group. Halothane 124-133 interleukin 1 beta Rattus norvegicus 182-190 29379356-10 2018 The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group. Sevoflurane 110-121 interleukin 1 beta Rattus norvegicus 182-190 29379356-10 2018 The proinflammatory cytokines including IL-10 and IL-4 was significantly higher in sevoflurane, halothane and sevoflurane + halothane group rats after anesthesia and the whole brain IL-1beta was significantly decrease in the sevoflurane, halothane and sevoflurane + halothane as compared to control group. Halothane 124-133 interleukin 1 beta Rattus norvegicus 182-190 28385490-0 2018 Manganese exposure facilitates microglial JAK2-STAT3 signaling and consequent secretion of TNF-a and IL-1beta to promote neuronal death. Manganese 0-9 interleukin 1 beta Rattus norvegicus 101-109 29281967-10 2017 Vitamin D administrations reduced IL-1beta, NF-Kbeta and acetylcholine concentration and BDNF concentrations in ND + vitamin D compared with ND group. Vitamin D 0-9 interleukin 1 beta Rattus norvegicus 34-42 29267220-11 2017 In vitro, galangin markedly inhibited LPS-induced expression of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta), cyclooxygenase 2 (COX-2), and induced nitric oxide synthase (iNOS) via associating with the phosphorylation of c-JUN N-terminal Kinase (JNK), p38, protein kinase B (AKT), and nuclear factor kappaB (NF-kappaB) p65. galangin 10-18 interleukin 1 beta Rattus norvegicus 130-147 29032684-8 2017 In contrast, supplementation with 480 and 640 mg/L boron had the opposite effect on the above indicators in rats and elevated levels of pro-inflammatory cytokines, such as interleukin 6 (IL-6), interleukin 1beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha) (p < 0.05). Boron 51-56 interleukin 1 beta Rattus norvegicus 213-221 28926473-9 2017 Moreover, hydrogen gas suppressed NF-kappaB phosphorylation and nuclear translocation and reduced the production of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha following sevoflurane administration. Sevoflurane 192-203 interleukin 1 beta Rattus norvegicus 116-133 29312516-6 2017 In addition, SalA also decreased the release of inflammation cytokines (i.e., TNF-alpha, IL-1beta, IL-6, and IL-8) in SAH rats. salvianolic acid A 13-17 interleukin 1 beta Rattus norvegicus 89-97 29244751-4 2017 Interleukin-1beta and interferon-gamma induced substantial cytotoxicity to RINm5F rat insulinoma cells, increasing nitric oxide (NO) production, nuclear factor-kappa B (NF-kappaB) activity, the expression of endoplasmic reticulum (ER) stress genes, and activation of mitogen-activated protein kinases and key genes related apoptosis. rinm5f 75-81 interleukin 1 beta Rattus norvegicus 0-17 29244751-4 2017 Interleukin-1beta and interferon-gamma induced substantial cytotoxicity to RINm5F rat insulinoma cells, increasing nitric oxide (NO) production, nuclear factor-kappa B (NF-kappaB) activity, the expression of endoplasmic reticulum (ER) stress genes, and activation of mitogen-activated protein kinases and key genes related apoptosis. Nitric Oxide 115-127 interleukin 1 beta Rattus norvegicus 0-17 29236702-6 2017 In the peritoneal macrophages from obese rats, tumor necrosis factor (TNF) alpha, interleukin 1beta and CD36 were increased, and were further increased in nicotine-treated obese rats. Nicotine 155-163 interleukin 1 beta Rattus norvegicus 82-99 29311826-5 2017 We found that methylene blue inhibited the protein levels of IL-1beta and IL-18 rather than their mRNA levels in activated microglia. Methylene Blue 14-28 interleukin 1 beta Rattus norvegicus 61-69 28926473-9 2017 Moreover, hydrogen gas suppressed NF-kappaB phosphorylation and nuclear translocation and reduced the production of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha following sevoflurane administration. Hydrogen 10-18 interleukin 1 beta Rattus norvegicus 116-133 29371912-9 2017 Moreover, decreased cell viability induced by IS was shown to be attenuated by IL-1beta or IL-18-neutralizing antibody. Indican 46-48 interleukin 1 beta Rattus norvegicus 79-87 29399548-9 2017 In addition, IL-1beta concentration was lowered by 0.1mg/rat of verapamil (P<0.05). Verapamil 64-73 interleukin 1 beta Rattus norvegicus 13-21 27288252-7 2017 Moreover, inhibition of HIF-1alpha by injection of 2-methoxyestradiol (2-MET) significantly decreased the amplified expression IL-6, TNF-alpha, IL-6R and TNFR1 in diabetic retina, but did not modify IL-1beta pathway. 2-Methoxyestradiol 71-76 interleukin 1 beta Rattus norvegicus 199-207 29255417-7 2017 Paclitaxel significantly increased the expression of inflammatory cytokines including tumor necrosis factor-alpha (2.2 times) and interleukin-1beta (2.7 times) in the lumbar dorsal root ganglion, and rolipram significantly decreased it. Paclitaxel 0-10 interleukin 1 beta Rattus norvegicus 130-147 29255417-8 2017 In addition, phosphodiesterase-4 and interleukin-1beta were expressed in the dorsal root ganglion neurons and satellite cells and paclitaxel significantly increased the intensity of interleukin-1beta (2 times) and rolipram significantly decreased it. Paclitaxel 130-140 interleukin 1 beta Rattus norvegicus 182-199 29255417-8 2017 In addition, phosphodiesterase-4 and interleukin-1beta were expressed in the dorsal root ganglion neurons and satellite cells and paclitaxel significantly increased the intensity of interleukin-1beta (2 times) and rolipram significantly decreased it. Rolipram 214-222 interleukin 1 beta Rattus norvegicus 37-54 27288252-6 2017 With increasing HIF-1alpha retinal PICs including IL-1beta, IL-6 and TNF-alpha, their respective receptors, namely IL-1R, IL-6R and TNFR1, were also elevated in STZ rats. Streptozocin 161-164 interleukin 1 beta Rattus norvegicus 50-58 27288252-7 2017 Moreover, inhibition of HIF-1alpha by injection of 2-methoxyestradiol (2-MET) significantly decreased the amplified expression IL-6, TNF-alpha, IL-6R and TNFR1 in diabetic retina, but did not modify IL-1beta pathway. 2-Methoxyestradiol 51-69 interleukin 1 beta Rattus norvegicus 199-207 29399548-11 2017 Conclusion: Verapamil has significant anti-inflammatory and anti-angiogenesis effects in the air pouch model probably due to attenuation effects of verapamil on IL-1beta and VEGF. Verapamil 12-21 interleukin 1 beta Rattus norvegicus 161-169 29399548-11 2017 Conclusion: Verapamil has significant anti-inflammatory and anti-angiogenesis effects in the air pouch model probably due to attenuation effects of verapamil on IL-1beta and VEGF. Verapamil 148-157 interleukin 1 beta Rattus norvegicus 161-169 28986735-9 2017 Furthermore, NO2 exposure promoted the increase in the expression of mucin gene (MUC5AC) and pro-inflammatory factors [interleukin (IL)-1beta, intercellular adhesion molecule-1 (ICAM-1), and IL-6] as well as serum OVA-specific immunoglobulin E (IgE) production. Nitrogen Dioxide 13-16 interleukin 1 beta Rattus norvegicus 119-141 28084090-8 2017 Further analysis demonstrated salidroside markedly suppressed the release of tumor necrosis factor-alpha and interleukin-1beta. rhodioloside 30-41 interleukin 1 beta Rattus norvegicus 109-126 28238753-6 2017 GILZ silencing attenuated the anti-inflammatory effects of intravitreal injection of triamcinolone acetonide (TA) in the EIU retina, as demonstrated by increased retinal interleukin (IL)-1beta, monocyte chemoattractant protein (MCP)-1and intercellular cell adhesion molecule-1 expression at 18 h after TA injection. Triamcinolone Acetonide 85-108 interleukin 1 beta Rattus norvegicus 170-192 28238753-6 2017 GILZ silencing attenuated the anti-inflammatory effects of intravitreal injection of triamcinolone acetonide (TA) in the EIU retina, as demonstrated by increased retinal interleukin (IL)-1beta, monocyte chemoattractant protein (MCP)-1and intercellular cell adhesion molecule-1 expression at 18 h after TA injection. Triamcinolone Acetonide 110-112 interleukin 1 beta Rattus norvegicus 170-192 28990108-10 2017 Anagliptin altered the serum activity of IL-6, IL-1beta and TNF-alpha (P<0.01). anagliptin 0-10 interleukin 1 beta Rattus norvegicus 47-55 28791506-7 2017 Subsequently, the effects of paeoniflorin on the production of inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) were detected by qPCR and ELISA. peoniflorin 29-41 interleukin 1 beta Rattus norvegicus 87-95 28812173-12 2017 Oxaliplatin injection also enhanced the messenger RNA (mRNA) expressions of cytokines including interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) and chemokines including monocyte chemoattractant protein-1 (MCP-1) and monocyte inflammatory protein-1 (MIP-1alpha) in the spinal dorsal horn, which could be significantly repressed by melatonin. Oxaliplatin 0-11 interleukin 1 beta Rattus norvegicus 96-113 28812173-12 2017 Oxaliplatin injection also enhanced the messenger RNA (mRNA) expressions of cytokines including interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) and chemokines including monocyte chemoattractant protein-1 (MCP-1) and monocyte inflammatory protein-1 (MIP-1alpha) in the spinal dorsal horn, which could be significantly repressed by melatonin. Oxaliplatin 0-11 interleukin 1 beta Rattus norvegicus 115-123 28944913-10 2017 Serum levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and IL-18 in the oleanolic acid-treated diabetic rats were downregulated. Oleanolic Acid 91-105 interleukin 1 beta Rattus norvegicus 45-67 28944913-11 2017 Consistent with the serum results, it was demonstrated that oleanolic acid administration caused a significant decrease in the levels of NLRP3, caspase-1 and IL-1beta in the carotid arteries of diabetic rats. Oleanolic Acid 60-74 interleukin 1 beta Rattus norvegicus 158-166 28825114-5 2017 All the protein levels of OX-42, GFAP, TNF-a, IL-1beta, COX-2, and iNOS are increased in CCH rats. 1-acetyl-2-(coumariniminecarboxamide-3-yl)hydrazine 89-92 interleukin 1 beta Rattus norvegicus 46-54 28825114-6 2017 WIN and URB downregulated the levels of OX-42, GFAP, TNF-alpha, IL-1beta, COX-2 and iNOS and inhibited CCH-induced ROS accumulation in CCH rats, indicating that WIN and URB might exert their neuroprotective effects by inhibiting the neuroinflammatory response. cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester 8-11 interleukin 1 beta Rattus norvegicus 64-72 28447512-9 2017 Hepatic concentrations of IL-1beta, MCP-1 and TNF-alpha in DCA group were reduced to 68%, 75% and 63% of DC values, respectively. Dichloroacetic Acid 59-62 interleukin 1 beta Rattus norvegicus 26-34 29067744-5 2017 The extract suppressed glycosaminoglycan release from the cartilage explant in the presence of Interleukin-1beta. Glycosaminoglycans 23-40 interleukin 1 beta Rattus norvegicus 95-112 28548620-4 2017 Baicalein significantly inhibited the releases of inflammatory mediators such as nitric oxide, interleukin-6, interleukin-1 beta, and tumor necrosis factor-alpha in d-gal-induced aging model. baicalein 0-9 interleukin 1 beta Rattus norvegicus 110-161 28812176-3 2017 After treated by SH (24.3 mg/kg), the abnormal morphology changes of lung tissues in COPD rats, such as neutrophil infiltration and airway obstruction, were considerably alleviated, as well as both proinflammatory cytokines, TNF-alpha and IL-1beta, significantly decreased in BALF. sodium houttuyfonate 17-19 interleukin 1 beta Rattus norvegicus 239-247 28365854-7 2017 Our results showed that dioscin not only reduced the levels of plasma lipid, TNF-a, IL-1beta and IL-6, but also inhibited atherosclerotic development in AS rats, as evidenced by decreased atherosclerotic lesions size and aortic lipid level. dioscin 24-31 interleukin 1 beta Rattus norvegicus 84-92 28365854-8 2017 In vitro study revealed dioscin directly reduced foam cell formation, decreased intracellular cholesterol accumulation and lowered TNF-a, IL-1beta and IL-6 secretion in ox-LDL treated macrophages. dioscin 24-31 interleukin 1 beta Rattus norvegicus 138-146 28844098-7 2017 Treatment with DBA increased the protein and mRNA expression of Iba-1, NF-kappaB, TNF-alpha, IL-6, IL-1beta and HO-1 in the hippocampus and pre-frontal cortex of rats. dibromoacetic acid 15-18 interleukin 1 beta Rattus norvegicus 99-107 29344175-9 2017 Andrographolide decreased NSE, S-100beta, and the inflammation factors, IL-6, IL-1beta and TNF-alpha in serum. andrographolide 0-15 interleukin 1 beta Rattus norvegicus 78-86 29128802-10 2017 Prior IS significantly increased plasma IL-1beta level induced by subsequent combined CS for 3days+acute RS, but significantly or totally inhibited the acute stress-induced increase of plasma IL-1beta level after 7 and 14days of combined stress. Cesium 86-88 interleukin 1 beta Rattus norvegicus 40-48 28628927-10 2017 Both curcumin and MyD88 siRNA inhibited the mRNA expression of MyD88 pathway-related effectors (TLR2, TLR4, NF-kappaB, TNF-alpha, IL-1beta) in HSC. Curcumin 5-13 interleukin 1 beta Rattus norvegicus 130-138 29551938-8 2017 But compared with the ischemia-reperfusion group, the total flavonoid of ilex pubesceus can significantly or obviously increase the iNOS activity, IL-1beta content and TNF-alpha content in the brain tissue of the rats. Flavonoids 60-69 interleukin 1 beta Rattus norvegicus 147-155 28990110-9 2017 Furthermore, butylphthalide significantly increased the level of SOD, reduced MDA levels, and reduced TNF-alpha, IL-1beta, and IL-6 levels in the hippocampus when compared with the DM group. 3-n-butylphthalide 13-27 interleukin 1 beta Rattus norvegicus 113-121 29184072-7 2017 ADM supplementation reversed the significantly increased gene expression levels and concentrations of TNF-alpha, IL-1beta, TGF-beta1, MCP-1 and MIF. Adrenomedullin 0-3 interleukin 1 beta Rattus norvegicus 113-121 29376267-7 2017 At the same time, SPJ could significantly inhibit the protein expression of Bax, IL-1beta, TNF-alpha and Ac-NF-kappaB p65, and increase the expression of Bcl-2, Bcl-2/Bax, p-AMPK/AMPK and Sirt1 in the heart tissues of natural aging rats. (3R,3'R)-N~1~,N~1~'-butane-1,4-diyldibutane-1,3-diamine 18-21 interleukin 1 beta Rattus norvegicus 81-89 29180332-6 2017 RESULTS: Compared with those in the sham-operated group, normal and diabetic rats in IR and DP groups showed significantly lowered MAP, HR, and RPP and increased levels of plasma CTnI, TNF-a, IL-6, IL-10 and IL-1beta levels after 30 min of ischemia and at 30 min and 120 min of reperfusion (P<0.05). dp 92-94 interleukin 1 beta Rattus norvegicus 208-216 29084866-3 2017 Treatment with exenatide in cultured primary spinal microglia concentration dependently stimulated the expression of the M2 microglial markers IL-10, IL-4, Arg 1, and CD206, but not the M1 microglial markers TNF-alpha, IL-1beta, IL-6, or CD68. Exenatide 15-24 interleukin 1 beta Rattus norvegicus 219-227 29180332-7 2017 Compared with those in the IR group, the normal rats in DP group showed decreased MAP, HR, and RPP at 30 min of ischemia and at 30 min of reperfusion, which increased at 120 min of reperfusion (P<0.05); the infarct size and plasma CTnI, TNF-a, IL-6 and IL-1beta levels were decreased while IL-10 was increased in DP group (P<0.05). dp 56-58 interleukin 1 beta Rattus norvegicus 256-264 29209167-0 2017 Heme Oxygenase-1 Induction by Carbon Monoxide Releasing Molecule-3 Suppresses Interleukin-1beta-Mediated Neuroinflammation. Carbon Monoxide 30-45 interleukin 1 beta Rattus norvegicus 78-95 29180332-8 2017 Compared with those in DP group, the rats in DM-DP group showed similar MAP, HR and RPP (P>0.05) but significantly increased infarct size and plasma CTnI, TNF-a, IL-6 and IL-1beta levels (P<0.05). dm-dp 45-50 interleukin 1 beta Rattus norvegicus 174-182 28993160-0 2017 Inhibition of morphine tolerance by MrgC receptor via modulation of interleukin-1beta and matrix metalloproteinase 9 in dorsal root ganglia in rats. Morphine 14-22 interleukin 1 beta Rattus norvegicus 68-85 28993160-5 2017 administration of morphine (20microg) increased the expression of interleukin-1beta (IL-1beta) and matrix metalloproteinase-9 (MMP-9) in small- and medium-sized neurons in dorsal root ganglia (DRG). Morphine 18-26 interleukin 1 beta Rattus norvegicus 66-83 28993160-5 2017 administration of morphine (20microg) increased the expression of interleukin-1beta (IL-1beta) and matrix metalloproteinase-9 (MMP-9) in small- and medium-sized neurons in dorsal root ganglia (DRG). Morphine 18-26 interleukin 1 beta Rattus norvegicus 85-93 28993160-10 2017 The treatment with BAM8-22 for 1h inhibited chronic morphine-induced increase of MMP-9 and IL-1beta mRNA in DRG but these effects were abolished by MrgC receptor antibody. bovine adrenal medulla 8-22 19-26 interleukin 1 beta Rattus norvegicus 91-99 28993160-10 2017 The treatment with BAM8-22 for 1h inhibited chronic morphine-induced increase of MMP-9 and IL-1beta mRNA in DRG but these effects were abolished by MrgC receptor antibody. Hydrogen 31-33 interleukin 1 beta Rattus norvegicus 91-99 28993160-10 2017 The treatment with BAM8-22 for 1h inhibited chronic morphine-induced increase of MMP-9 and IL-1beta mRNA in DRG but these effects were abolished by MrgC receptor antibody. Morphine 52-60 interleukin 1 beta Rattus norvegicus 91-99 28993160-11 2017 The treatment with BAM8-22 for 24 and 72h respectively inhibited and enhanced morphine-induced expression of MMP-9 and IL-1beta mRNA in the cultured DRG. Morphine 78-86 interleukin 1 beta Rattus norvegicus 119-127 28993160-13 2017 The results suggest that the inhibition of IL-1beta and MMP-9 expressions in DRG underlain the modulation of morphine tolerance by the acute activation of MrgC receptors. Morphine 109-117 interleukin 1 beta Rattus norvegicus 43-51 28993160-14 2017 The chronic activation of MrgC receptors can facilitate morphine-induced increase of MMP-9 and IL-1beta expressions in DRG. Morphine 56-64 interleukin 1 beta Rattus norvegicus 95-103 28673836-11 2017 15d-PGJ2 cream associated with MNs also significantly reduced the release of tumor necrosis factor-alpha and interleukin-1 beta, which are pro-inflammatory cytokines. 15-deoxy-delta(12,14)-prostaglandin J2 0-8 interleukin 1 beta Rattus norvegicus 109-127 28673836-11 2017 15d-PGJ2 cream associated with MNs also significantly reduced the release of tumor necrosis factor-alpha and interleukin-1 beta, which are pro-inflammatory cytokines. 3,4-methylenedioxy-beta-nitrostyrene 31-34 interleukin 1 beta Rattus norvegicus 109-127 28931778-5 2017 Nicotine (10 nM) significantly inhibited LPS-induced mRNA expression of IL-1beta and iNOS, but not TNF-alpha and MCP-1. Nicotine 0-8 interleukin 1 beta Rattus norvegicus 72-80 28869897-9 2017 Single administration of thalidomide significantly reduced production of cytokines (tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta) in serum but not in the brain, and attenuated upregulation of NMDA receptor (NR) 2A/B subunits in the hippocampus at POD 14. Thalidomide 25-36 interleukin 1 beta Rattus norvegicus 122-144 28931778-6 2017 In addition, the alpha7 nicotinic acetylcholine receptor selective agonist, PNU-282987 (10 nM), significantly inhibited LPS-induced mRNA expression of IL-1beta but not TNF-alpha, iNOS and MCP-1. N-neopentyl-N-nitrosourea 76-79 interleukin 1 beta Rattus norvegicus 151-159 28962079-8 2017 Whereas expressions of proinflammatory gene such as tumor necrosis factor alpha, interlukin-6, IL-1beta and cycloxygenase -2 (COX-2) was found to be reduced in corilagin treated group than I/R group. corilagin 160-169 interleukin 1 beta Rattus norvegicus 95-103 29151689-10 2017 While earliest morphological signs of inflammation in liver were visible after 6 h, increased expression of the two acute-phase cytokines IFN-gamma (1h) and IL-1beta (3h) was detectable earlier, with maximum values after 12-24 h. Iron concentrations in liver tissue increased steadily between 1 h and 48 h, and remained high at 96 h. In contrast, spleen iron concentrations remained unchanged until 48 h, and increased mildly thereafter (96 h). Tritium 167-169 interleukin 1 beta Rattus norvegicus 157-165 29151689-10 2017 While earliest morphological signs of inflammation in liver were visible after 6 h, increased expression of the two acute-phase cytokines IFN-gamma (1h) and IL-1beta (3h) was detectable earlier, with maximum values after 12-24 h. Iron concentrations in liver tissue increased steadily between 1 h and 48 h, and remained high at 96 h. In contrast, spleen iron concentrations remained unchanged until 48 h, and increased mildly thereafter (96 h). Iron 230-234 interleukin 1 beta Rattus norvegicus 157-165 28675823-0 2017 Endothelial immunocytochemical expression of pituitary IL-1beta and its relation to ACTH-positive cells is regulated by corticosterone in the male rat. Corticosterone 120-134 interleukin 1 beta Rattus norvegicus 55-63 28461107-8 2017 Tofacitinib down-regulated significantly the frequency of CD4+IFN-gamma+ T cells and reduced IL-1beta mRNA expression levels in the spleen of the treated rats. tofacitinib 0-11 interleukin 1 beta Rattus norvegicus 93-101 28858724-0 2017 Alpha-Mangostin protects rat articular chondrocytes against IL-1beta-induced inflammation and slows the progression of osteoarthritis in a rat model. mangostin 0-15 interleukin 1 beta Rattus norvegicus 60-68 28910961-0 2017 Paeonol alleviates interleukin-1beta-induced inflammatory responses in chondrocytes during osteoarthritis. paeonol 0-7 interleukin 1 beta Rattus norvegicus 19-36 28910961-4 2017 The purpose of this study was to investigate whether paeonol could alleviate the progression of OA through inhibition of IL-1beta-induced inflammatory responses in chondrocytes. paeonol 53-60 interleukin 1 beta Rattus norvegicus 121-129 28910961-9 2017 The results showed that paeonol could negatively affect IL-1beta-mediate chondrocyte apoptosis and proliferation. paeonol 24-31 interleukin 1 beta Rattus norvegicus 56-64 28910961-10 2017 Application of paeonol attenuated the secretion of cartilage extracellular matrix and cartilage degrading enzymes induced by IL-1beta in chondrocytes. paeonol 15-22 interleukin 1 beta Rattus norvegicus 125-133 28910961-11 2017 Increasing of ROS production by IL-1beta was obviously alleviated by paeonol. Reactive Oxygen Species 14-17 interleukin 1 beta Rattus norvegicus 32-40 28910961-11 2017 Increasing of ROS production by IL-1beta was obviously alleviated by paeonol. paeonol 69-76 interleukin 1 beta Rattus norvegicus 32-40 28915536-11 2017 Losartan with simvastatin produced similar effects on renal tissues oxidative stress, nitrite and inflammatory markers levels and on protein expressions of eNOS, iNOS, TNF-alpha, IL-6 and IL-1beta. Losartan 0-8 interleukin 1 beta Rattus norvegicus 188-196 28915536-11 2017 Losartan with simvastatin produced similar effects on renal tissues oxidative stress, nitrite and inflammatory markers levels and on protein expressions of eNOS, iNOS, TNF-alpha, IL-6 and IL-1beta. Simvastatin 14-25 interleukin 1 beta Rattus norvegicus 188-196 28915439-0 2017 Alpha-Mangostin suppresses interleukin-1beta-induced apoptosis in rat chondrocytes by inhibiting the NF-kappaB signaling pathway and delays the progression of osteoarthritis in a rat model. mangostin 0-15 interleukin 1 beta Rattus norvegicus 27-44 28675666-6 2017 The anti-inflammatory activity of PGA-g-HA was confirmed in IL-1beta-stimulated chondrocytes. Prostaglandins A 34-37 interleukin 1 beta Rattus norvegicus 60-68 28682524-7 2017 PC induced inflammatory responses by increasing the levels of TNF-alpha and IL-1beta. Acetaminophen 0-2 interleukin 1 beta Rattus norvegicus 76-84 27796742-9 2017 The CLP rats treated with simvastatin showed a reduction in nitric oxide (P < 0.05), IL1-beta (P < 0.001), IL-6 (P < 0.01), and TBARS levels (P < 0.001) and an increase in catalase activity (P < 0.01), citrate synthase enzyme (P < 0.05), and normalized GSH/GSSG ratio. Simvastatin 26-37 interleukin 1 beta Rattus norvegicus 88-96 27744573-8 2017 STZ-infused rats showed significant learning and memory deficit which was associated with an increase in oxidative stress (lipid peroxidation and nitrite), compromised antioxidant defense (reduced glutathione), neurotransmitter alterations (AChE, dopamine, noradrenaline, 5-hydroxytryptamine, gama amino butyric acid, and glutamate), and elevation in neuroinflammatory cytokine (IL-1 beta, IL-6, and TNF-alpha) levels. Streptozocin 0-3 interleukin 1 beta Rattus norvegicus 379-388 28470940-5 2017 3"-O-(4-benzoyl) benzoyl adenosine 5"-triphosphate (BzATP), a P2X7 R agonist, induced caspase-1 activation and mature IL-1beta release, which was further neutralized by a NLRP3 inhibitor (16673-34-0). 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 0-50 interleukin 1 beta Rattus norvegicus 118-126 28470940-5 2017 3"-O-(4-benzoyl) benzoyl adenosine 5"-triphosphate (BzATP), a P2X7 R agonist, induced caspase-1 activation and mature IL-1beta release, which was further neutralized by a NLRP3 inhibitor (16673-34-0). BzATP 52-57 interleukin 1 beta Rattus norvegicus 118-126 28470940-13 2017 In vitro studies showed that BzATP up-regulated secretion of nerve growth factor (NGF) in M1 macrophages via IL-1beta. BzATP 29-34 interleukin 1 beta Rattus norvegicus 109-117 28776262-12 2017 In addition, vaspin significantly inhibited IL-1beta-induced ROS generation and MMP-2 activation in PASMCs. Reactive Oxygen Species 61-64 interleukin 1 beta Rattus norvegicus 44-52 28849083-9 2017 Tanshinone IIA treatment significantly reduced the levels of inflammatory cytokines, including interleukin-1beta, tumor necrosis factor-alpha and nitric oxide in rat serum samples. tanshinone 0-14 interleukin 1 beta Rattus norvegicus 95-141 28901458-5 2017 It was revealed that treatment with curcumin significantly reduced interleukin (IL)-1beta and IL-6, iNOS, COX-2 and MMP-9 levels in rats with LIDD. Curcumin 36-44 interleukin 1 beta Rattus norvegicus 67-89 28944915-8 2017 IPTF pretreatment decreased the activities of total nitric oxide synthase (TNOS), induced NOS (iNOS) and constitutive NOS (cNOS), and the levels of nitric oxide (NO), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), however, it increased the levels of IL-10 in brain tissues. iptf 0-4 interleukin 1 beta Rattus norvegicus 167-184 28944915-8 2017 IPTF pretreatment decreased the activities of total nitric oxide synthase (TNOS), induced NOS (iNOS) and constitutive NOS (cNOS), and the levels of nitric oxide (NO), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), however, it increased the levels of IL-10 in brain tissues. iptf 0-4 interleukin 1 beta Rattus norvegicus 186-194 28849211-12 2017 In addition, the inositol-requiring enzyme 1 pathway mediated the ER stress associated with autophagy and inflammatory cytokines (IL1beta and caspase-1). Inositol 17-25 interleukin 1 beta Rattus norvegicus 130-137 28664397-8 2017 PBM tolerance reduced peripheral LPS-induced elevation of serum TNF-alpha, IL-1beta expression and TLR4 expression in PBM. pbm 0-3 interleukin 1 beta Rattus norvegicus 75-83 28776262-12 2017 In addition, vaspin significantly inhibited IL-1beta-induced ROS generation and MMP-2 activation in PASMCs. pasmcs 100-106 interleukin 1 beta Rattus norvegicus 44-52 29125102-0 2017 Role of Methylprednisolone in Treatment of Spinal Cord Injured with Bone Marrow Mesenchymal Stem Cells Transplantation in Rats and Its Effect on the Expressions of Tumor Necrosis Factor-alpha and Interleukin-1beta. Methylprednisolone 8-26 interleukin 1 beta Rattus norvegicus 196-213 28637971-6 2017 Moreover, EsA inhibited excessive generation of pro-inflammatory tumor necrosis factor-alpha, IL-1beta, and IL-6 in the serum and downregulated cyclooxygenase-2 and inducible nitric oxide synthase in the renal tissues of septic rats. esculentoside A 10-13 interleukin 1 beta Rattus norvegicus 94-102 28772214-8 2017 Oral administration of EGCG for one month after diabetes induction significantly protected the increase in serum levels of pro-inflammatory cytokines (IL-1 beta, IL-6 and TNF-alpha) and adhesion molecules (ICAM-1 and VCAM-1), suggesting its anti-inflammatory potential. epigallocatechin gallate 23-27 interleukin 1 beta Rattus norvegicus 151-160 28734929-15 2017 Serum levels of MDA, IL-1beta and TNF-alpha were significantly lower in the aripiprazole group. Aripiprazole 76-88 interleukin 1 beta Rattus norvegicus 21-29 29207603-0 2017 Effects of baicalein on IL-1beta-induced inflammation and apoptosis in rat articular chondrocytes. baicalein 11-20 interleukin 1 beta Rattus norvegicus 24-32 29207603-2 2017 In this study, we examined the anti-inflammatory and anti-apoptotic effect of baicalein on IL-1beta signaling and NF-kappaB-regulated gene products in rat chondrocytes. baicalein 78-87 interleukin 1 beta Rattus norvegicus 91-99 29207603-8 2017 Baicalein inhibited the NF-kappaB activation that was induced by IL-1beta in a time-dependent manner in chondrocytes. baicalein 0-9 interleukin 1 beta Rattus norvegicus 65-73 28710069-8 2017 Dox increased the levels of cardiac proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6, whereas the expression of Vit C transporter proteins (sodium-ascorbate cotransporter 2 and glucose transporter 4) was reduced. Doxorubicin 0-3 interleukin 1 beta Rattus norvegicus 73-81 29049348-1 2017 This study evaluated the chronic effects of fluoxetine, a commonly prescribed SSRI antidepressant, on the peripheral and central levels of inflammatory cytokines including IL-1beta, IL-6, TNF-alpha and IL-17 over a 4-interval in a rat model of chronic mild stress (CMS) which resembles the human experience of depression. Fluoxetine 44-54 interleukin 1 beta Rattus norvegicus 172-180 29049348-8 2017 Rats treated with fluoxetine demonstrated lower IL-1beta in plasma and brain after 90 and 120-day treatment respectively (p<0.05). Fluoxetine 18-28 interleukin 1 beta Rattus norvegicus 48-56 29049348-10 2017 This study revealed the potential therapeutic effects of fluoxetine by reducing central and peripheral levels of IL-1beta in the alleviation of depressive symptoms. Fluoxetine 57-67 interleukin 1 beta Rattus norvegicus 113-121 28969701-10 2017 In HT rats, bazedoxifene restored the mRNA level of ERalpha and ERbeta and decreased the level of interleukin-1beta and matrix metalloproteinase-9. bazedoxifene 12-24 interleukin 1 beta Rattus norvegicus 98-115 28800541-8 2017 Levels of TNF-alpha, IL-1beta, IL-6, MCP-1 and NO in myocardial tissues, together with levels of CTnI in serum were significantly declined in simvastatin-treated rats. Simvastatin 142-153 interleukin 1 beta Rattus norvegicus 21-29 28912867-7 2017 CS-CrmA microspheres significantly inhibited IL-1beta-induced inflammation in chondrocytes by attenuating increases in the gene expression levels of inducible nitric oxide synthase and cyclooxygenase-2, as well as the concentrations of nitric oxide and prostaglandin E2. Chitosan 0-2 interleukin 1 beta Rattus norvegicus 45-53 28912867-7 2017 CS-CrmA microspheres significantly inhibited IL-1beta-induced inflammation in chondrocytes by attenuating increases in the gene expression levels of inducible nitric oxide synthase and cyclooxygenase-2, as well as the concentrations of nitric oxide and prostaglandin E2. crma 3-7 interleukin 1 beta Rattus norvegicus 45-53 28912867-9 2017 In addition, CS-CrmA microspheres blocked IL-1beta-induced chondrocyte apoptosis by increasing B-cell lymphoma 2 (Bcl-2) and decreasing Bcl-2-associated X protein, caspase-3 and poly adenosine diphosphate-ribose polymerase expression at the mRNA and protein levels, as indicated by reverse-transcription quantitative polymerase chain reaction and western blot analysis, respectively. crma 16-20 interleukin 1 beta Rattus norvegicus 42-50 28966691-8 2017 Results also indicated that treatment with wogonoside significantly reduced the levels of IL-1beta, TNF-alpha and IL-6 in rats with SCI-induced inflammation (P<0.01), potentially via the phosphorylation of NF-kappaB inhibitor alpha. wogonoside 43-53 interleukin 1 beta Rattus norvegicus 90-98 28912867-7 2017 CS-CrmA microspheres significantly inhibited IL-1beta-induced inflammation in chondrocytes by attenuating increases in the gene expression levels of inducible nitric oxide synthase and cyclooxygenase-2, as well as the concentrations of nitric oxide and prostaglandin E2. nitric 159-165 interleukin 1 beta Rattus norvegicus 45-53 28912867-10 2017 The results of the present study revealed that CS-CrmA microspheres, as a controlled release system of CrmA, may protect rat chondrocytes from IL-1beta-induced inflammation and apoptosis via regulating inflammatory and apoptosis-associated genes. Chitosan 47-49 interleukin 1 beta Rattus norvegicus 143-151 28912867-10 2017 The results of the present study revealed that CS-CrmA microspheres, as a controlled release system of CrmA, may protect rat chondrocytes from IL-1beta-induced inflammation and apoptosis via regulating inflammatory and apoptosis-associated genes. crma 50-54 interleukin 1 beta Rattus norvegicus 143-151 28912867-7 2017 CS-CrmA microspheres significantly inhibited IL-1beta-induced inflammation in chondrocytes by attenuating increases in the gene expression levels of inducible nitric oxide synthase and cyclooxygenase-2, as well as the concentrations of nitric oxide and prostaglandin E2. Nitric Oxide 159-171 interleukin 1 beta Rattus norvegicus 45-53 28912867-7 2017 CS-CrmA microspheres significantly inhibited IL-1beta-induced inflammation in chondrocytes by attenuating increases in the gene expression levels of inducible nitric oxide synthase and cyclooxygenase-2, as well as the concentrations of nitric oxide and prostaglandin E2. Dinoprostone 253-269 interleukin 1 beta Rattus norvegicus 45-53 28912867-8 2017 CS-CrmA microspheres significantly decreased the number of apoptotic chondrocytes induced by IL-1beta as indicated by a terminal deoxyribonucleotide transferase deoxyuridine triphosphate nick-end labeling assay. Chitosan 0-2 interleukin 1 beta Rattus norvegicus 93-101 28912867-8 2017 CS-CrmA microspheres significantly decreased the number of apoptotic chondrocytes induced by IL-1beta as indicated by a terminal deoxyribonucleotide transferase deoxyuridine triphosphate nick-end labeling assay. crma 3-7 interleukin 1 beta Rattus norvegicus 93-101 28912867-9 2017 In addition, CS-CrmA microspheres blocked IL-1beta-induced chondrocyte apoptosis by increasing B-cell lymphoma 2 (Bcl-2) and decreasing Bcl-2-associated X protein, caspase-3 and poly adenosine diphosphate-ribose polymerase expression at the mRNA and protein levels, as indicated by reverse-transcription quantitative polymerase chain reaction and western blot analysis, respectively. Chitosan 13-15 interleukin 1 beta Rattus norvegicus 42-50 28667503-4 2017 Citral given by gavage caused no change in control euthermic rats (treated with saline) but blunted most of the assessed parameters related to the sickness syndrome [fever (hallmark of infection), plasma cytokines (IL-1beta, IL-6, and TNF-alpha) release, and prostaglandin E2 (PGE2) synthesis (both peripherally and hypothalamic)]. citral 0-6 interleukin 1 beta Rattus norvegicus 215-223 28667503-6 2017 These data are consistent with the notion that citral has a corticosterone-independent potent antipyretic effect, acting on the peripheral febrigenic signaling (plasma levels of IL-1beta, IL-6, TNF-alpha, and PGE2), eventually down-modulating hypothalamic PGE2 production. citral 47-53 interleukin 1 beta Rattus norvegicus 178-186 28664399-12 2017 Furthermore, metformin downregulated the levels of apoptotic factors (p-JNK3, p-c-Jun and cleaved caspase-3) as well as pro-inflammatory cytokines (IL-1beta, IL-4 and IL-6 and TNF-alpha). Metformin 13-22 interleukin 1 beta Rattus norvegicus 148-156 28782532-9 2017 Ghrelin could inhibit the increased protein levels of NLRP3, caspase-1, and IL-1beta induced by lipopolysacharide in primary cultured cardiomyocytes of neonatal rats. lipopolysacharide 96-113 interleukin 1 beta Rattus norvegicus 76-84 28397014-4 2017 4NQO provoked inflammation by upregulating the expressions of the p65 subunit nuclear factor kappa-beta (NF-kappaB) in the nucleus, tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS). 4-Nitroquinoline-1-oxide 0-4 interleukin 1 beta Rattus norvegicus 173-190 28397014-4 2017 4NQO provoked inflammation by upregulating the expressions of the p65 subunit nuclear factor kappa-beta (NF-kappaB) in the nucleus, tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS). 4-Nitroquinoline-1-oxide 0-4 interleukin 1 beta Rattus norvegicus 192-200 28608236-12 2017 In addition, nicotine treatment increased lipid peroxidation and the levels of GSH, IL-1beta, TNF-alpha and Bax, while reducing Bcl-2, P-CREB and BDNF levels in the hippocampus. Nicotine 13-21 interleukin 1 beta Rattus norvegicus 84-92 29084331-9 2017 Additionally, the protein level of MCP-1 in the aqueous humor and mRNA levels of IL-1beta, IL-6, TNF-alpha, MCP-1, and intercellular adhesion molecule-1 in the ICB and retina were suppressed by ripasudil. K-115 194-203 interleukin 1 beta Rattus norvegicus 81-89 28643232-7 2017 Co-treatment with caffeine significantly decreased these upregulations at all time points investigated, while caffeine without phenobarbital resulted in increased expression of TNFalpha, IL-1beta, and IL-18, but not IFNgamma at 6 h. Downregulation of the adenosine A1 and A2a receptors, both of which bind caffeine, by 24 h of phenobarbital exposure was partly antagonized by caffeine. Caffeine 18-26 interleukin 1 beta Rattus norvegicus 187-195 29375052-10 2017 Increased levels of serum TNF-alpha, IL-1beta, IL-10 in the saline-treated ulcer group, as compared to control group, were significantly decreased in the nesfatin-1-treated ulcer group. Sodium Chloride 60-66 interleukin 1 beta Rattus norvegicus 37-45 28643232-6 2017 RNA expression of the pro-inflammatory cytokines TNFalpha, IFNgamma, and IL-1beta, but not IL-18, was upregulated by phenobarbital. Phenobarbital 117-130 interleukin 1 beta Rattus norvegicus 73-81 28643232-7 2017 Co-treatment with caffeine significantly decreased these upregulations at all time points investigated, while caffeine without phenobarbital resulted in increased expression of TNFalpha, IL-1beta, and IL-18, but not IFNgamma at 6 h. Downregulation of the adenosine A1 and A2a receptors, both of which bind caffeine, by 24 h of phenobarbital exposure was partly antagonized by caffeine. Caffeine 110-118 interleukin 1 beta Rattus norvegicus 187-195 28643232-7 2017 Co-treatment with caffeine significantly decreased these upregulations at all time points investigated, while caffeine without phenobarbital resulted in increased expression of TNFalpha, IL-1beta, and IL-18, but not IFNgamma at 6 h. Downregulation of the adenosine A1 and A2a receptors, both of which bind caffeine, by 24 h of phenobarbital exposure was partly antagonized by caffeine. Caffeine 110-118 interleukin 1 beta Rattus norvegicus 187-195 28643232-7 2017 Co-treatment with caffeine significantly decreased these upregulations at all time points investigated, while caffeine without phenobarbital resulted in increased expression of TNFalpha, IL-1beta, and IL-18, but not IFNgamma at 6 h. Downregulation of the adenosine A1 and A2a receptors, both of which bind caffeine, by 24 h of phenobarbital exposure was partly antagonized by caffeine. Caffeine 110-118 interleukin 1 beta Rattus norvegicus 187-195 28974974-8 2017 In addition, salbutamol decreased the production of VEGF and IL-1beta. Albuterol 13-23 interleukin 1 beta Rattus norvegicus 61-69 28974974-13 2017 The observed IL-1beta and VEGF inhibitory properties of salbutamol may be responsible for anti-inflammatory and anti-angiogenic effect of the agent. Albuterol 56-66 interleukin 1 beta Rattus norvegicus 13-21 29026307-9 2017 The results showed that the levels of ROS, malondialdehyde, NF-kappaB, p-NF-kappaB, tumor necrosis factor-alpha and interleukin-1beta were markedly increased after PQ treatment. Paraquat 164-166 interleukin 1 beta Rattus norvegicus 116-133 28421347-11 2017 CPT-11 caused a significant increase in the expression of TLR4, IL-6, TNF-alpha, IL-1beta and caspase-3 mRNAs in the large intestine. Irinotecan 0-6 interleukin 1 beta Rattus norvegicus 81-89 28780351-11 2017 Moreover, SB203580, an inhibitor of p38 MAPK/NF-kappaB signal pathway, could further enhance the inhibitory effects of KCNQ1OT1 suppression on the expression of p-p38, TNF-alpha, IL-6, IL-1beta and p-NF-kappaB in OGD/R-induced myocardial H9C2 cells. SB 203580 10-18 interleukin 1 beta Rattus norvegicus 185-193 28973966-5 2017 We found that adult rats exposed to an acute binge-like level of alcohol, regardless of gestational alcohol exposure, have a robust increase in the expression of Interleukin (IL)-6 within the brain, and a significant decrease in the expression of IL-1beta and CD11b. Alcohols 65-72 interleukin 1 beta Rattus norvegicus 247-255 29026298-12 2017 Additionally, LX-NM significantly attenuated the rise of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta, prostaglandin E2, nuclear factor-kappabeta, malondialdehyde and nitric oxide serum levels. lx-nm 14-19 interleukin 1 beta Rattus norvegicus 98-115 28771433-7 2017 RESULTS: The chronic treatment with paracetamol led to renal dysfunction, represented by the elevation of plasma urea and creatinine and the decline in the enzymatic antioxidant status, but did not cause a significant increase in TNF-alpha and IL-1beta. Acetaminophen 36-47 interleukin 1 beta Rattus norvegicus 244-252 28903766-11 2017 Administration of AC-YVAD-CMK, a caspase-1 inhibitor, reduced the expression of IL-1beta and IL-18 and the number of PI-positive cells, attenuated brain edema, and improved neurological function, which was also observed in fluoxetine-treated rats. ac-yvad 18-25 interleukin 1 beta Rattus norvegicus 80-88 28983255-9 2017 Microinjection of baclofen into the LHA obviously reduced the expression of inflammatory factor IL-1beta, NOX2, and NOX4 in the gastric mucosa. Baclofen 18-26 interleukin 1 beta Rattus norvegicus 96-104 28648404-8 2017 Moreover, Osthole down-regulated the pro-inflammatory factors TNF-alpha and IL-1beta and NF-kappaB (p65), whose expression had been upregulated after balloon injury. osthol 10-17 interleukin 1 beta Rattus norvegicus 76-84 28648404-11 2017 We concluded that Osthole significantly inhibited neointimal hyperplasia in balloon-induced rat carotid artery injury and that the mechanism by which this occurs may involve NF-kappaB, IL-1beta and TNF-alpha down-regulation, which alleviates the inflammatory response, and TGF-beta1/Smad2 signalling pathway inhibition. osthol 18-25 interleukin 1 beta Rattus norvegicus 185-193 28928666-9 2017 Simultaneously, (+-)-8-ADC also increased XBP1 expression, and decreased NF-kappaB expression and secretion of myeloperoxidase, TNF-alpha, IL-6 and IL-1beta in the colon. (+-)-8-adc 16-26 interleukin 1 beta Rattus norvegicus 148-156 28928666-6 2017 In vitro, (+-)-8-ADC activated the transcriptional activity of XBP1, inhibited expression of NF-kappaB, and reduced production of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta), in lipopolysaccharide-stimulated IEC6 cells. (+-)-8-adc 10-20 interleukin 1 beta Rattus norvegicus 209-227 28704755-5 2017 Increased release of inflammatory cytokines (TNF, IL-1beta and IL-10) was noted by skin explants from rats which received warfarin, but without effect on IL-6. Warfarin 122-130 interleukin 1 beta Rattus norvegicus 50-58 28928666-6 2017 In vitro, (+-)-8-ADC activated the transcriptional activity of XBP1, inhibited expression of NF-kappaB, and reduced production of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta), in lipopolysaccharide-stimulated IEC6 cells. (+-)-8-adc 10-20 interleukin 1 beta Rattus norvegicus 229-237 28962159-7 2017 In addition, EAEG decreased plasma levels of tumor necrosis factor-alpha and interleukin-1beta in the rat model of inflammation. eaeg 13-17 interleukin 1 beta Rattus norvegicus 77-94 28731135-11 2017 On the whole, we expounded that GTW, as a natural regulator in vivo, alleviates GS without affecting hyperglycemia, by exerting anti-microinflammatory effects, including reducing macrophage infiltration in glomeruli, suppressing TNF-alpha, IL-1beta and TGF-beta1 overexpression in the kidney and inhibiting p38 MAPK and NF-kappaB signaling activities. GTW 32-35 interleukin 1 beta Rattus norvegicus 240-248 28560522-4 2017 RESULTS: The hepatoprotective effects of HMBA against CCl4-induced liver damage, were evident from low serum transaminases activities, reduced hepatic lipid peroxidation and collagen content, restoration of total glutathione, and recouping of the inflammatory cytokines, such as TNF-alpha, IL-1beta, IL-10, and IL-6 levels. 2-hydroxy-4-methoxy benzoic acid 41-45 interleukin 1 beta Rattus norvegicus 290-298 28284975-9 2017 Increased oxidative stress and increased levels of TNF-alpha, IL-1beta induced by STZ were also significantly attenuated by taurine. Streptozocin 82-85 interleukin 1 beta Rattus norvegicus 62-70 28741143-8 2017 SAL alleviated mechanical and thermal hyperalgesia and reduced TNF-alpha and IL-1beta in sciatic nerve and spinal cord in DM rats. rhodioloside 0-3 interleukin 1 beta Rattus norvegicus 77-85 28714024-5 2017 Magnesium isoglycyrrhizinate suppressed the activities of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, superoxide dismutase, glutathione peroxidase, inducible nitric oxide synthase (iNOS) and caspase-3 in RIRI model rats. 18alpha,20beta-hydroxy-11-oxo-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranurosyl-alpha-D-glucopyranosiduronate magnesium tetrahydrate 0-28 interleukin 1 beta Rattus norvegicus 87-109 28407665-5 2017 Insulin sensitivity was assessed by intraperitoneal glucose tolerance test and homeostasis model assessment index, and through analysis of insulin signaling pathway in the visceral adipose tissue.Dihydrotestosterone treatment led to increased body weight, abdominal obesity and elevated triglycerides and non-esterified fatty acids, which were accompanied by the activation of nuclear factor kappa B and increase in macrophage migration inhibitory factor, IL6 and IL1beta levels in the visceral adipose tissue. Dihydrotestosterone 196-215 interleukin 1 beta Rattus norvegicus 464-471 28529112-10 2017 Moreover, 10mug ST2825 prevented the proconvulsant actions of IL-1beta. ST2825 16-22 interleukin 1 beta Rattus norvegicus 62-70 28529112-12 2017 Our results revealed that 10mug ST2825 markedly reversed the increased Tyr1472-phosphorylation of the NR2B subunit of NMDA receptor observed in the proconvulsant conditions of IL-1beta and in seizures induced by pilocarpine alone. ST2825 32-38 interleukin 1 beta Rattus norvegicus 176-184 28606823-8 2017 ALA reduced BBB permeability and TNF-alpha levels in hippocampus in 24 h and IL-1beta levels and MPO activity in hippocampus and prefrontal cortex in 24 h. ALA reduced nitrite/nitrate concentration and lipid peroxidation in 24 h in all structures and protein carbonylation in 12 and 24 h in hippocampus and cortex. Thioctic Acid 156-159 interleukin 1 beta Rattus norvegicus 77-85 28511952-3 2017 We determined that LiCl -attenuated LPS-induced activated toll-like receptor 4 (TLR4) signalling and significantly reduced the nuclear factor-kB (NF-KB) translation factor and various other inflammatory mediators such as interleukin-1 beta (IL-1beta) and tumour necrosis factor alpha (TNF-alpha). Lithium Chloride 19-23 interleukin 1 beta Rattus norvegicus 221-239 28511952-3 2017 We determined that LiCl -attenuated LPS-induced activated toll-like receptor 4 (TLR4) signalling and significantly reduced the nuclear factor-kB (NF-KB) translation factor and various other inflammatory mediators such as interleukin-1 beta (IL-1beta) and tumour necrosis factor alpha (TNF-alpha). Lithium Chloride 19-23 interleukin 1 beta Rattus norvegicus 241-249 28284975-9 2017 Increased oxidative stress and increased levels of TNF-alpha, IL-1beta induced by STZ were also significantly attenuated by taurine. Taurine 124-131 interleukin 1 beta Rattus norvegicus 62-70 28720397-3 2017 ISO-induced myocardial damage was indicated by elevated levels of cardiac specific troponin-T, enhanced myocardial expression of proinflammatory cytokines (interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha), and increased number of cells with apoptotic and necrotic appearance in the myocardial tissue. Isoproterenol 0-3 interleukin 1 beta Rattus norvegicus 156-173 28273031-9 2017 The mean IL-1beta level was significantly lower in D-Cys-Asn-Ser and Arg-Cys-Asn-Ser groups compared with I/R group (both p <= 0.046). d-cys-asn 51-60 interleukin 1 beta Rattus norvegicus 9-17 28851350-0 2017 Preventive effects of the novel antimicrobial peptide Nal-P-113 in a rat Periodontitis model by limiting the growth of Porphyromonas gingivalis and modulating IL-1beta and TNF-alpha production. nal-p-113 54-63 interleukin 1 beta Rattus norvegicus 159-167 28851350-13 2017 CONCLUSIONS: Nal-P-113 exhibited protective effects on Porphyromonas gingivalis-induced periodontitis in rats by limiting the amount of bacteria and modulating IL-1beta and TNF-alpha production. nal-p-113 13-22 interleukin 1 beta Rattus norvegicus 160-168 29207635-7 2017 Ad-SOCS2 infection alleviated STZ-induced renal injury and pathological changes and inhibited STZ-induced IL-6, IL-1beta and MCP-1 generation and activation of the TLR4/NF-kappaB pathway in DN rats. Streptozocin 94-97 interleukin 1 beta Rattus norvegicus 112-120 28823689-5 2017 injection of interleukin-1beta (IL-1beta) after the cessation of ethanol exposure. Ethanol 65-72 interleukin 1 beta Rattus norvegicus 13-30 28823689-5 2017 injection of interleukin-1beta (IL-1beta) after the cessation of ethanol exposure. Ethanol 65-72 interleukin 1 beta Rattus norvegicus 32-40 29089075-8 2017 Pyruvate treatment significantly promoted cell proliferation and inhibited cell apoptosis, decreased the levels of IL-1beta, IL-6 and TNF-alpha, and depressed p38MAPK phosphorylation. Pyruvic Acid 0-8 interleukin 1 beta Rattus norvegicus 115-123 28273031-9 2017 The mean IL-1beta level was significantly lower in D-Cys-Asn-Ser and Arg-Cys-Asn-Ser groups compared with I/R group (both p <= 0.046). Serine 61-64 interleukin 1 beta Rattus norvegicus 9-17 28273031-9 2017 The mean IL-1beta level was significantly lower in D-Cys-Asn-Ser and Arg-Cys-Asn-Ser groups compared with I/R group (both p <= 0.046). Arginine 69-72 interleukin 1 beta Rattus norvegicus 9-17 28273031-9 2017 The mean IL-1beta level was significantly lower in D-Cys-Asn-Ser and Arg-Cys-Asn-Ser groups compared with I/R group (both p <= 0.046). Cysteine 53-56 interleukin 1 beta Rattus norvegicus 9-17 28273031-9 2017 The mean IL-1beta level was significantly lower in D-Cys-Asn-Ser and Arg-Cys-Asn-Ser groups compared with I/R group (both p <= 0.046). Asparagine 57-60 interleukin 1 beta Rattus norvegicus 9-17 28273031-9 2017 The mean IL-1beta level was significantly lower in D-Cys-Asn-Ser and Arg-Cys-Asn-Ser groups compared with I/R group (both p <= 0.046). Serine 81-84 interleukin 1 beta Rattus norvegicus 9-17 28691484-4 2017 In vitro, the nanosensor allows the monitoring of the NO release in interleukin-1beta-stimulated chondrocytes and the alleviated effect of NG-monomethyl-l-arginine (a NO inhibitor) and andrographolide (an anti-inflammatory agent). andrographolide 185-200 interleukin 1 beta Rattus norvegicus 68-85 28832497-8 2017 Dexmedetomidine decreased the LPS-induced neuroinflammation in the hippocampus and cortex via significant reduction of the IL1-beta and TNF-alpha gene expressions after 24 h. Moreover, the LPS-mediated increased expressions of miR 124, 132, 134, and 155 were significantly decreased after dexmedetomidine treatment in both brain regions. Dexmedetomidine 0-15 interleukin 1 beta Rattus norvegicus 123-131 28806392-0 2017 Kaempferol Alleviates the Interleukin-1beta-Induced Inflammation in Rat Osteoarthritis Chondrocytes via Suppression of NF-kappaB. kaempferol 0-10 interleukin 1 beta Rattus norvegicus 26-43 28806392-1 2017 BACKGROUND This study was designed to examine the anti-inflammatory and anti-osteoarthritis (OA) effects of kaempferol in rat articular chondrocytes stimulated with interleukin-1beta. kaempferol 108-118 interleukin 1 beta Rattus norvegicus 165-182 28806392-6 2017 RESULTS Kaempferol treatment (up to 100 muM) in a concentration-dependent way caused reduction in the interleukin-1b-stimulated formations of PGE2 and NO. kaempferol 8-18 interleukin 1 beta Rattus norvegicus 102-116 28806392-6 2017 RESULTS Kaempferol treatment (up to 100 muM) in a concentration-dependent way caused reduction in the interleukin-1b-stimulated formations of PGE2 and NO. Dinoprostone 142-146 interleukin 1 beta Rattus norvegicus 102-116 28806392-7 2017 Kaempferol also upregulated the expression of iNOS and Cox-2 in interleukin-1beta-stimulated rat OA chondrocytes. kaempferol 0-10 interleukin 1 beta Rattus norvegicus 64-81 28806392-8 2017 Additionally, kaempferol was found to inhibit the IkBa degradation and NF-kappaB activation in rat chondrocytes stimulated with interleukin-1beta. kaempferol 14-24 interleukin 1 beta Rattus norvegicus 128-145 28806392-9 2017 CONCLUSIONS Kaempferol significantly caused reduction in interleukin-1beta-stimulated pro-inflammatory mediators in rat OA chondrocytes by inhibiting the NF-kappaB pathway. kaempferol 12-22 interleukin 1 beta Rattus norvegicus 57-74 28824433-6 2017 Glucose-fed rats displayed hyperglycemia, hyperinsulinemia, hyperleptinemia, insulin resistance, hypertension, positive body weight gain, and enhanced expression of B1R, CPM, iNOS, and IL-1beta in renal cortex, aorta and liver. Glucose 0-7 interleukin 1 beta Rattus norvegicus 185-193 28614179-8 2017 Furthermore, H2 treatment significantly ameliorated the increase in serum and hippocampal proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and high-mobility group protein 1 in surgery-challenged animals. Hydrogen 13-15 interleukin 1 beta Rattus norvegicus 145-162 28478517-6 2017 We observed significantly downregulated mRNA expressions for IL-1beta and TNF-alpha in blood and tissue samples 24 and 120 h post I/R injury in VPA-treated animals compared to control groups (P < 0.0001). VALPROIC ACID 144-147 interleukin 1 beta Rattus norvegicus 61-69 28552911-7 2017 In consistence with the in vitro studies, PL administration significantly decreased the expression of TNF-alpha, IL-1beta and IL-6 in gingiva of the rat with CP, with the dosage 4 mg kg-1 d-1 showing the best anti-inflammatory effect. plumbagin 42-44 interleukin 1 beta Rattus norvegicus 113-121 28299811-0 2017 The role of interleukin-1b and its antagonist (diacerein) in estradiol benzoate-induced endometrial hyperplasia and atypia in female rats. estradiol 3-benzoate 61-79 interleukin 1 beta Rattus norvegicus 12-26 28477248-5 2017 Flu also inhibited the levels of cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta). Fluoxetine 0-3 interleukin 1 beta Rattus norvegicus 120-137 28477248-5 2017 Flu also inhibited the levels of cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta). Fluoxetine 0-3 interleukin 1 beta Rattus norvegicus 139-147 28478514-3 2017 Salidroside also decreased IL-6, IL-1beta, TNF-alpha, CD14, CD44, and iNOs mRNAs. rhodioloside 0-11 interleukin 1 beta Rattus norvegicus 33-41 28514495-9 2017 Also, dioscin affected levels of AP-1, COX-2, HMGB1, IkappaB-alpha, IL-1beta, IL-6 and TNF-alpha and decreased the ratio of acetylated NF-kappaB and normal NF-kappaB, to suppress inflammation. dioscin 6-13 interleukin 1 beta Rattus norvegicus 68-76 28703832-7 2017 iNOS, COX-2, NOX-1, tumor necrosis factor alpha (TNFalpha) and interleukin 1beta (IL1beta) expressions were higher in the mesenteric arteries from TNBS-treated rats, without changes in both eNOS expression and eNOS-Ser1177 phosphorylation. Trinitrobenzenesulfonic Acid 147-151 interleukin 1 beta Rattus norvegicus 63-80 28703832-7 2017 iNOS, COX-2, NOX-1, tumor necrosis factor alpha (TNFalpha) and interleukin 1beta (IL1beta) expressions were higher in the mesenteric arteries from TNBS-treated rats, without changes in both eNOS expression and eNOS-Ser1177 phosphorylation. Trinitrobenzenesulfonic Acid 147-151 interleukin 1 beta Rattus norvegicus 82-89 28703832-8 2017 The in vivo pre-treatment with 5 mg kg-1 of the flavonoid quercitrin reverts both the early hyporesponse of mesenteric arteries to noradrenaline and the up-regulation of iNOS, COX2, NOX1, TNFalpha and IL1beta in colitic rats. Flavonoids 48-57 interleukin 1 beta Rattus norvegicus 201-208 28703832-8 2017 The in vivo pre-treatment with 5 mg kg-1 of the flavonoid quercitrin reverts both the early hyporesponse of mesenteric arteries to noradrenaline and the up-regulation of iNOS, COX2, NOX1, TNFalpha and IL1beta in colitic rats. quercitrin 58-68 interleukin 1 beta Rattus norvegicus 201-208 28627596-0 2017 Regulation of type II collagen, matrix metalloproteinase-13 and cell proliferation by interleukin-1beta is mediated by curcumin via inhibition of NF-kappaB signaling in rat chondrocytes. Curcumin 119-127 interleukin 1 beta Rattus norvegicus 86-103 29151078-9 2017 Moreover, treatment with ghrelin increased mucosal blood flow and DNA synthesis in the gum, while a local inflammation was decreased what was observed as a reduction in mucosal concentration of pro-inflammatory interleukin-1beta. Ghrelin 25-32 interleukin 1 beta Rattus norvegicus 211-228 28656223-6 2017 In contrast, the CaCl2-induced TAA formation was inhibited by pre-administering rapamycin to CaCl2-treated rats, which demonstrated attenuated mTOR phosphorylation and downregulation of the proinflammatory mediators (i.e., TNF-alpha, IL-6, IL-1beta, matrix metallopeptidases 2 and 9) to the control level. Calcium Chloride 93-98 interleukin 1 beta Rattus norvegicus 240-248 29067449-6 2017 Furthermore, diosgenin inhibited CCI-induced upregulated levels of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-2, and suppressed oxidative stress induced by CCI in the spinal cord. Diosgenin 13-22 interleukin 1 beta Rattus norvegicus 127-149 29067449-6 2017 Furthermore, diosgenin inhibited CCI-induced upregulated levels of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-2, and suppressed oxidative stress induced by CCI in the spinal cord. CCI 33-36 interleukin 1 beta Rattus norvegicus 127-149 28656223-6 2017 In contrast, the CaCl2-induced TAA formation was inhibited by pre-administering rapamycin to CaCl2-treated rats, which demonstrated attenuated mTOR phosphorylation and downregulation of the proinflammatory mediators (i.e., TNF-alpha, IL-6, IL-1beta, matrix metallopeptidases 2 and 9) to the control level. Calcium Chloride 17-22 interleukin 1 beta Rattus norvegicus 240-248 28205387-7 2017 Fructose was found to downregulate miR-330 expression to increase SphK1/S1P/S1PR1/3 signaling, and then activate NF-kappaB/NLRP3 inflammasome to produce IL-1beta, causing insulin signaling impairment. Fructose 0-8 interleukin 1 beta Rattus norvegicus 153-161 28627596-8 2017 Curcumin was demonstrated to inhibit the IL-1beta-induced activation of NF-kappaB by suppressing IkappaBalpha phosphorylation and p65/RelA nuclear translocation. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 41-49 28627596-10 2017 CCK-8 assays revealed that co-treatment with curcumin resulted in increased proliferation in IL-1beta-treated chondrocytes. Curcumin 45-53 interleukin 1 beta Rattus norvegicus 93-101 28587937-3 2017 Thus, we aim to investigate the strontium ranelate efficacy in reducing the zymosan-induced inflammatory hypernociception in the TMJ of rats by evaluating the TNF-alpha, IL-1beta, and hemeoxygenase-1 (HO-1) involvement. strontium ranelate 32-50 interleukin 1 beta Rattus norvegicus 170-178 28505603-10 2017 Further, the anti-autophagic property of ICA was evidenced by amelioration of the decrease in mTOR and p70S6 kinase expression and an increase in TLR4, NFkappaB, IL1-beta, and COX-2 immunohistochemically. icariin 41-44 interleukin 1 beta Rattus norvegicus 162-170 28527875-9 2017 Magnolol had an anti-inflammatory effect mediated by a decrease in the expression of IL-1beta and TNF-alpha in the brain tissue. magnolol 0-8 interleukin 1 beta Rattus norvegicus 85-93 28738820-9 2017 RESULTS: It was found that omega-3 PUFA supplementation inhibited TBI-induced microglial activation and expression of inflammatory factors (TNF-alpha, IL-1beta, IL-6, and IFN-gamma), reduced brain edema, decreased neuronal apoptosis, and improved neurological functions after TBI. omega-3 pufa 27-39 interleukin 1 beta Rattus norvegicus 151-159 28527691-3 2017 The effect of IL-1beta on the blood glucose level of animals was examined in glucose tolerance test (GTT), and concentrations of relevant plasma metabolites (total cholesterol, HDL, LDH, triglycerides, uric acid) were additionally also determined following the above microinjections. Glucose 36-43 interleukin 1 beta Rattus norvegicus 14-22 28527691-5 2017 Prostaglandin-mediated mechanisms were shown to have important role in the mode of this action of IL-1beta, since paracetamol pretreatment partially prevented the development of the above mentioned hyperthermia. Prostaglandins 0-13 interleukin 1 beta Rattus norvegicus 98-106 28527691-5 2017 Prostaglandin-mediated mechanisms were shown to have important role in the mode of this action of IL-1beta, since paracetamol pretreatment partially prevented the development of the above mentioned hyperthermia. Acetaminophen 114-125 interleukin 1 beta Rattus norvegicus 98-106 28527691-7 2017 Following IL-1beta microinjection, however, significant decrease of HDL and total cholesterol was found. Cholesterol 82-93 interleukin 1 beta Rattus norvegicus 10-18 28458159-4 2017 Our results showed that celastrol reduced the expression of catabolic genes (MMP-3, 9, 13, ADAMTS-4, 5), oxidative stress factors (COX-2, iNOS) and pro-inflammatory factors (IL-6, TNF-a) induced by IL-1beta in nucleus pulposus cells, also phosphorylation of IkappaBalpha and p65 were attenuated by celastrol, indicating NF-kappaB pathway was inhibited by celastrol in nucleus pulposus cells. celastrol 24-33 interleukin 1 beta Rattus norvegicus 198-206 28947973-0 2017 Hyperbaric oxygen protects type II collagen in interleukin-1beta-induced mandibular condylar chondrocyte via inhibiting the JNK/c-Jun signaling pathway. Oxygen 11-17 interleukin 1 beta Rattus norvegicus 47-64 28947973-1 2017 The aim of this study was to explore the mechanisms of Hyperbaric oxygen (HBO) protective on interleukin-1beta (IL-1beta) induced rat"s mandibular condylar chondrocytes. Oxygen 66-72 interleukin 1 beta Rattus norvegicus 93-110 28947973-1 2017 The aim of this study was to explore the mechanisms of Hyperbaric oxygen (HBO) protective on interleukin-1beta (IL-1beta) induced rat"s mandibular condylar chondrocytes. Oxygen 66-72 interleukin 1 beta Rattus norvegicus 112-120 28947973-2 2017 Chondrocytes were exposure to Hyperbaric oxygen after induced inflammatory by IL-1beta. Oxygen 41-47 interleukin 1 beta Rattus norvegicus 78-86 28947973-6 2017 However, Hyperbaric oxygen can inhibits IL-1beta induced inflammatory response in chondrocytes though block the JNK/c-Jun signaling pathway and up-regulate the expression of Sox-9 and COL2. Oxygen 20-26 interleukin 1 beta Rattus norvegicus 40-48 28499240-10 2017 RESULTS: Maximum infiltration of inflammatory cells and the highest level of IL-1beta in the prostate tissue was observed in T2+AL(OH)3+CFA group as revealed by histopathology and Immunohistochemistry, respectively. t2+al(oh)3 125-135 interleukin 1 beta Rattus norvegicus 77-85 28499240-10 2017 RESULTS: Maximum infiltration of inflammatory cells and the highest level of IL-1beta in the prostate tissue was observed in T2+AL(OH)3+CFA group as revealed by histopathology and Immunohistochemistry, respectively. 3-chloro-4-fluoroaniline 136-139 interleukin 1 beta Rattus norvegicus 77-85 28686201-6 2017 MC and HGPC LPS-stimulated splenocytes produced less IL-1beta and IL-6 than Control. Methylcholanthrene 0-2 interleukin 1 beta Rattus norvegicus 53-61 28686201-6 2017 MC and HGPC LPS-stimulated splenocytes produced less IL-1beta and IL-6 than Control. hgpc 7-11 interleukin 1 beta Rattus norvegicus 53-61 28680032-14 2017 In the sham group, there was little IL-1beta/IL-6, and fentanyl significantly inhibited SAP-induced up-regulation of IL-1beta/IL-6 levels. Fentanyl 55-63 interleukin 1 beta Rattus norvegicus 117-125 28499974-5 2017 CSIS caused depressive- and anxiety-like behaviors, compromised GSH-dependent defense, and induced nuclear factor-kappa B (NF-kappaB) activation with a concomitant increase in cytosolic levels of proinflammatory mediators cyclooxigenase-2, interleukin-1beta and tumor necrosis factor-alpha in the PFC. csis 0-4 interleukin 1 beta Rattus norvegicus 240-289 28319517-13 2017 Serum levels of tumor necrosis factor-alpha, IL-1beta, IL-6, and high-sensitivity C-reactive protein were decreased in lidocaine-loaded groups compared with group S or P at 1, 2, and 48 hours, and 2 weeks after surgery, respectively. Lidocaine 119-128 interleukin 1 beta Rattus norvegicus 45-53 28285348-2 2017 Our results showed that pretreatment with KHG26693 significantly attenuated glutamate-induced elevation of lipid peroxidation, tumor necrosis factor-alpha, interferon gamma, IFN-gamma, interleukin-1beta, nitric oxide, reactive oxygen species, NADPH oxidase, caspase-3, calpain activity, and Bax. N-adamantyl-4-methylthiazol-2-amine 42-50 interleukin 1 beta Rattus norvegicus 185-202 28460353-4 2017 In this study, CUMS treated rats showed a notable depressive-like behavior (decreased sucrose intake and locomotor activity, and increased immobility time), and significant increase in the activation of NLRP3 inflammasome and the levels of pro-inflammatory cytokines (IL-1beta and IL-6) in rat prefrontal cortex. cums 15-19 interleukin 1 beta Rattus norvegicus 268-276 28525856-10 2017 Moreover, OLE inhibited CD4+, CD8+ cells and macrophage infiltration in myocardium and decreased the serum production of tumour necrosis factor-a (TNF-a), interleukin-1beta (IL-1beta) and IL-6 in EAM rats. oleuropein 10-13 interleukin 1 beta Rattus norvegicus 155-172 28525856-10 2017 Moreover, OLE inhibited CD4+, CD8+ cells and macrophage infiltration in myocardium and decreased the serum production of tumour necrosis factor-a (TNF-a), interleukin-1beta (IL-1beta) and IL-6 in EAM rats. oleuropein 10-13 interleukin 1 beta Rattus norvegicus 174-182 28283331-3 2017 High-glucose (HG) and recombinant IL-1beta treatment were both shown to increase the expression of FoxO1 and IL-1beta in HRMECs in a dose-dependent manner. Glucose 5-12 interleukin 1 beta Rattus norvegicus 109-117 27572744-9 2017 Moreover, the results in hypoxia-treated primary spinal cord microglia confirmed the effect of FK-506 on TNF-a, IL-1b, and IL-6 expression and NF-kappaB activation. Tacrolimus 95-101 interleukin 1 beta Rattus norvegicus 112-117 28544775-1 2017 AIMS: We previously demonstrated that intrathecal IL-1beta upregulated phosphorylation of p38 mitogen-activated protein kinase (P-p38 MAPK) and inducible nitric oxide synthase (iNOS) in microglia and astrocytes in spinal cord, increased nitric oxide (NO) release into cerebrospinal fluid, and induced thermal hyperalgesia in rats. Nitric Oxide 154-166 interleukin 1 beta Rattus norvegicus 50-58 28544775-3 2017 METHODS: The pretreatment effects of MK-801 (5 mug), minocycline (20 mug), and SB203580 (5 mug) on intrathecal IL-1beta (100 ng) in rats were measured by behavior, Western blotting, CSF analysis, and immunofluorescence studies. Dizocilpine Maleate 37-43 interleukin 1 beta Rattus norvegicus 111-119 28544775-3 2017 METHODS: The pretreatment effects of MK-801 (5 mug), minocycline (20 mug), and SB203580 (5 mug) on intrathecal IL-1beta (100 ng) in rats were measured by behavior, Western blotting, CSF analysis, and immunofluorescence studies. Minocycline 53-64 interleukin 1 beta Rattus norvegicus 111-119 28544775-3 2017 METHODS: The pretreatment effects of MK-801 (5 mug), minocycline (20 mug), and SB203580 (5 mug) on intrathecal IL-1beta (100 ng) in rats were measured by behavior, Western blotting, CSF analysis, and immunofluorescence studies. SB 203580 79-87 interleukin 1 beta Rattus norvegicus 111-119 28544775-5 2017 MK-801 significantly inhibited all the IL-1beta-induced responses; however, minocycline and SB203580 blocked the IL-1beta-downregulated GTs and elevated glutamate but not the upregulated p-NR1. Dizocilpine Maleate 0-6 interleukin 1 beta Rattus norvegicus 39-47 28544775-5 2017 MK-801 significantly inhibited all the IL-1beta-induced responses; however, minocycline and SB203580 blocked the IL-1beta-downregulated GTs and elevated glutamate but not the upregulated p-NR1. Minocycline 76-87 interleukin 1 beta Rattus norvegicus 113-121 28544775-5 2017 MK-801 significantly inhibited all the IL-1beta-induced responses; however, minocycline and SB203580 blocked the IL-1beta-downregulated GTs and elevated glutamate but not the upregulated p-NR1. SB 203580 92-100 interleukin 1 beta Rattus norvegicus 39-47 28544775-5 2017 MK-801 significantly inhibited all the IL-1beta-induced responses; however, minocycline and SB203580 blocked the IL-1beta-downregulated GTs and elevated glutamate but not the upregulated p-NR1. SB 203580 92-100 interleukin 1 beta Rattus norvegicus 113-121 28544775-5 2017 MK-801 significantly inhibited all the IL-1beta-induced responses; however, minocycline and SB203580 blocked the IL-1beta-downregulated GTs and elevated glutamate but not the upregulated p-NR1. Glutamic Acid 153-162 interleukin 1 beta Rattus norvegicus 113-121 28283839-9 2017 RESULTS: Intrathecal administration of the PDE2A inhibitor Bay 60-7550, significantly attenuated mechanical allodynia, down-regulated spinal TNF-alpha, IL-1beta and IL-6 over-expressions, increased the expression of spinal cAMP, as well as cGMP in a more remarkable manner, and decreased the spinal PDE2A expression in NCLDH rats in a dose-dependent manner. 2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one 59-70 interleukin 1 beta Rattus norvegicus 152-160 28522306-7 2017 Furthermore, chronic testosterone administration decreased hypothalamic TNF-alpha mRNA levels in OVX rats, whereas it increased hypothalamic IL-1beta mRNA levels in OVX with estradiol-administered rats. Estradiol 174-183 interleukin 1 beta Rattus norvegicus 141-149 28487990-9 2017 BALF protein concentration, total leukocytes and eosinophils, peripheral blood expression levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and monocyte chemotactic protein 1 were significantly upregulated after THS induction, and each exhibited decreased expression upon LFM-A13 treatment. THYMIDINE-5'-(DITHIO)PHOSPHATE 230-233 interleukin 1 beta Rattus norvegicus 129-151 28285348-2 2017 Our results showed that pretreatment with KHG26693 significantly attenuated glutamate-induced elevation of lipid peroxidation, tumor necrosis factor-alpha, interferon gamma, IFN-gamma, interleukin-1beta, nitric oxide, reactive oxygen species, NADPH oxidase, caspase-3, calpain activity, and Bax. Glutamic Acid 76-85 interleukin 1 beta Rattus norvegicus 185-202 28410217-11 2017 Pterostilbene inhibited the level of COX-2, iNOS, PGE2, and NO, as well as the mitochondrial and total intracellular ROS production induced by IL-1beta in chondrocytes, partially reversed by the Nrf2 silencing. pterostilbene 0-13 interleukin 1 beta Rattus norvegicus 143-151 28839358-10 2017 ZBSO also decreased tumor necrosis factor alpha, interleukin-1 (IL-1) beta, and IL-6 levels in serum, upregulated IkappaBalpha, and downregulated p-NF-kappaB p65 and p-IkappaBalpha expression in vivo, indicating the anti-inflammatory action of ZBSO. zbso 0-4 interleukin 1 beta Rattus norvegicus 64-74 29903169-14 2017 Similarly, the levels of IL-1beta, IL-6 in bronchoalveolar lavage fluid had a decreasing trend with the increase of Ve and omega-3 FA compared with the PM_(2. omega-3 fa 123-133 interleukin 1 beta Rattus norvegicus 25-33 29903169-34 2017 Meanwhile, the levels of IL-1beta and TNF-alpha in cardiac tissue had an obvious decrease trend with the increase of Ve and omega-3 FA. omega-3 fa 124-134 interleukin 1 beta Rattus norvegicus 25-33 28410217-11 2017 Pterostilbene inhibited the level of COX-2, iNOS, PGE2, and NO, as well as the mitochondrial and total intracellular ROS production induced by IL-1beta in chondrocytes, partially reversed by the Nrf2 silencing. ros 117-120 interleukin 1 beta Rattus norvegicus 143-151 28410217-13 2017 These results suggest that pterostilbene could inhibit the IL-1beta-induced inflammation and ROS production in chondrocytes by stimulating the nuclear translocation of Nrf2. pterostilbene 27-40 interleukin 1 beta Rattus norvegicus 59-67 28410217-13 2017 These results suggest that pterostilbene could inhibit the IL-1beta-induced inflammation and ROS production in chondrocytes by stimulating the nuclear translocation of Nrf2. ros 93-96 interleukin 1 beta Rattus norvegicus 59-67 28322843-7 2017 Menthol also reduced significantly the colonic levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and myeloperoxidase (MPO) activity in inflamed colons. Menthol 0-7 interleukin 1 beta Rattus norvegicus 117-125 29134975-0 2017 Plasma Interleukin-1beta (IL-1beta) Concentrations at the Different Phases of the Oestrus Cycle in Clomiphene Treated Female Rats. Clomiphene 99-109 interleukin 1 beta Rattus norvegicus 7-24 29134975-0 2017 Plasma Interleukin-1beta (IL-1beta) Concentrations at the Different Phases of the Oestrus Cycle in Clomiphene Treated Female Rats. Clomiphene 99-109 interleukin 1 beta Rattus norvegicus 26-34 29134975-3 2017 It was thereforenecessary to determine plasma IL-1beta levels in female rats administered ovulation inducing agent clomiphene citrate. Clomiphene 115-133 interleukin 1 beta Rattus norvegicus 46-54 29134975-9 2017 The IL-1beta plasma concentrationswere higher in clomiphene treated rats at all the phases of the oestrus cycle of experimental rats when compared with thecontrol. Clomiphene 49-59 interleukin 1 beta Rattus norvegicus 4-12 29134975-10 2017 The increase in plasma IL-1beta was significant (p 0.05) in the estrus phase of the clomiphene citrate treated rats(550.53pg/ml) when compared with the control (304.42pg/ml). Clomiphene 84-102 interleukin 1 beta Rattus norvegicus 23-31 29134975-11 2017 The high plasma concentration of IL-1beta at the estrus phaseof clomiphene citrate treated rats suggests its possible involvement in oocyte maturation and ovulation which characterizesthe phase. Clomiphene 64-82 interleukin 1 beta Rattus norvegicus 33-41 28322843-7 2017 Menthol also reduced significantly the colonic levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and myeloperoxidase (MPO) activity in inflamed colons. Menthol 0-7 interleukin 1 beta Rattus norvegicus 98-115 29029441-3 2017 Curcumin significantly inhibited cell apoptosis, and decreased levels of LDH and production of TNF-a, IL-1b, and IL-6 in the cell supernatant. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 102-107 28638434-3 2017 RESULTS: We found Cr (VI) caused hepatotoxicity characterized by the alterations of several enzymatic and cytokine markers including aspartate aminotransferase (AST), alanine aminotransferase (ALT), interleukine-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha), etc. chromium hexavalent ion 18-25 interleukin 1 beta Rattus norvegicus 219-227 28428089-9 2017 MTX-UDLs-gel effectively suppressed the expression of pro-inflammatory cytokines, TNF-alpha and IL-1beta, in paw tissues. mtx-udls 0-8 interleukin 1 beta Rattus norvegicus 96-104 28495142-0 2017 N-methyl-d-aspartate receptor-mediated calcium overload and endoplasmic reticulum stress are involved in interleukin-1beta-induced neuronal apoptosis in rat hippocampus. Calcium 39-46 interleukin 1 beta Rattus norvegicus 105-122 28301301-8 2017 Moreover, TBBPA increased the levels of inflammatory cytokines (TNF-alpha and IL-1beta), nitric oxide, intracellular ROS, and mitochondrial superoxide. tetrabromobisphenol A 10-15 interleukin 1 beta Rattus norvegicus 78-86 28638224-11 2017 The levels of AST, ALT, TNF-alpha and IL-1beta in the model group increased significantly, and were significantly reduced by OMT pretreatment. oxymatrine 125-128 interleukin 1 beta Rattus norvegicus 38-46 28412496-1 2017 OBJECTIVE: As maternal treatment with magnesium sulfate (MG) may protect the fetal brain, we sought to assess the inflammation associated neuroprotective potential of MG and its association to interleukin 1beta (IL-1beta). Magnesium Sulfate 38-55 interleukin 1 beta Rattus norvegicus 212-220 28412496-1 2017 OBJECTIVE: As maternal treatment with magnesium sulfate (MG) may protect the fetal brain, we sought to assess the inflammation associated neuroprotective potential of MG and its association to interleukin 1beta (IL-1beta). Magnesium Sulfate 167-169 interleukin 1 beta Rattus norvegicus 193-210 28430709-5 2017 Vitamin D3 suppressed the expression of proinflammatory cytokines tumour necrosis factor-alpha, interleukin-1beta, vascular endothelial growth factor, and also TLR4 in activated astrocytes. Cholecalciferol 0-10 interleukin 1 beta Rattus norvegicus 96-113 28600519-8 2017 Interestingly, higher serum levels of IL-1beta and IL-6 in the rat with depression-like phenotype were normalized after a single dose of ketamine. Ketamine 137-145 interleukin 1 beta Rattus norvegicus 38-46 28638864-5 2017 Meanwhile, the bone mineral density and content (BMD and BMC) were substantially improved on supplementation with VA. Also, the bone turnover markers like calcium (Ca), phosphorous (P), osteocalcin (OC), alkaline phosphatase (ALP) and deoxypyridinoline (DPD) and inflammatory markers (IL-1beta, IL-6, and TNF-alpha) levels were markedly attenuated in VA-treated rats. Vanillic Acid 114-116 interleukin 1 beta Rattus norvegicus 285-293 28574475-6 2017 At 10 weeks, MC and HGPC offspring had a lower proportion of macrophages and dendritic cells and produced less interleukin (IL)-1beta but more IL-10 after lipopolysaccharide stimulation vs. Control pups (p < 0.05). Methylcholanthrene 13-15 interleukin 1 beta Rattus norvegicus 111-133 28215032-9 2017 Besides, the activation of NLRP3 inflammasome and secretion of IL-1beta and IL-18 in paraquat-treated rat renal tubular epithelial cells were inhibited by siRNA against DAPK. Paraquat 85-93 interleukin 1 beta Rattus norvegicus 63-71 28351778-9 2017 Theophylline treatment also reduced MPO activity and tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1 beta) and interleukin 6 (IL-6) concentrations in inflamed colon. Theophylline 0-12 interleukin 1 beta Rattus norvegicus 94-111 28351778-9 2017 Theophylline treatment also reduced MPO activity and tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1 beta) and interleukin 6 (IL-6) concentrations in inflamed colon. Theophylline 0-12 interleukin 1 beta Rattus norvegicus 113-122 28177673-0 2017 Interleukin-1beta suppresses the ventilatory hypoxic response in rats via prostaglandin-dependent pathways. Prostaglandins 74-87 interleukin 1 beta Rattus norvegicus 0-17 28177673-2 2017 The goal was to test the hypothesis that IL-1beta impairs the hypoxic ventilatory response in vivo by indirectly inhibiting respiratory neurons in the brainstem via prostaglandins. Prostaglandins 165-179 interleukin 1 beta Rattus norvegicus 41-49 28177673-7 2017 Thus, the data indicate that IL-1beta degrades the ventilatory hypoxic response by stimulating production of prostaglandin. Prostaglandins 109-122 interleukin 1 beta Rattus norvegicus 29-37 28588676-11 2017 The expression of iNOS in lung tissue and the concentration of TNF-alpha, IL-1beta and IL-10 in the bronchoalveolar lavage fluid of rats treated with saline was higher than in rats with XBJ pre-treatment. Sodium Chloride 150-156 interleukin 1 beta Rattus norvegicus 74-82 28588676-11 2017 The expression of iNOS in lung tissue and the concentration of TNF-alpha, IL-1beta and IL-10 in the bronchoalveolar lavage fluid of rats treated with saline was higher than in rats with XBJ pre-treatment. 4-fluoro-2-(4-(4-(2-hydroxypropan-2-yl)pyrrolidin-3-ylamino)-6,7-dimethoxyquinazolin-2-yl)phenol 186-189 interleukin 1 beta Rattus norvegicus 74-82 28501584-6 2017 Exposure of DEN up-regulated the levels of different serum biochemical parameters, antioxidant enzyme level, Alfa-fetoprotein (AFP) and reduced the level of High density lipoprotein (HDL) in Wistar rats along with the alteration in pro-inflammatory cytokines viz., interlukin-6 (IL-6), Tumor necrosis factor (TNF-alpha) and Interleukin-1beta (IL-1beta) with decrease in body weight. Diethylnitrosamine 12-15 interleukin 1 beta Rattus norvegicus 324-341 28501584-6 2017 Exposure of DEN up-regulated the levels of different serum biochemical parameters, antioxidant enzyme level, Alfa-fetoprotein (AFP) and reduced the level of High density lipoprotein (HDL) in Wistar rats along with the alteration in pro-inflammatory cytokines viz., interlukin-6 (IL-6), Tumor necrosis factor (TNF-alpha) and Interleukin-1beta (IL-1beta) with decrease in body weight. Diethylnitrosamine 12-15 interleukin 1 beta Rattus norvegicus 343-351 28177762-3 2017 Moreover, CIH promoted the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6, and activated mitogen-activated protein kinase (MAPK) family members, extracellular regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK), and P38, depending on the O2 concentration. cih 10-13 interleukin 1 beta Rattus norvegicus 76-98 28391163-9 2017 It also reversed the activity of IL-1beta that increased ROS and NO production. Reactive Oxygen Species 57-60 interleukin 1 beta Rattus norvegicus 33-41 28295853-5 2017 Our study found that matrine modulated the imbalance of Th1 and Th2 cytokine responses in rats with RA by reducing the levels of Th1 cytokines (IFN-gamma, TNF-alpha, IL-1beta), but increasing Th2 cytokine (IL-4 and IL-10) through attenuating the NF-kappaB signaling in T cells, suggesting matrine as a promising drug for intervention of RA. matrine 21-28 interleukin 1 beta Rattus norvegicus 166-174 28411046-4 2017 In the present study, the effect of chlorpromazine, haloperidol and risperidone (0.5, 5 or 10muM) on production of pro-inflammatory cytokines IL-1beta and TNF-alpha and anti-inflammatory IL-10 was investigated in the unstimulated and lipopolysaccharide-stimulated primary rat mixed glial cell cultures. Chlorpromazine 36-50 interleukin 1 beta Rattus norvegicus 142-150 28411046-4 2017 In the present study, the effect of chlorpromazine, haloperidol and risperidone (0.5, 5 or 10muM) on production of pro-inflammatory cytokines IL-1beta and TNF-alpha and anti-inflammatory IL-10 was investigated in the unstimulated and lipopolysaccharide-stimulated primary rat mixed glial cell cultures. Haloperidol 52-63 interleukin 1 beta Rattus norvegicus 142-150 28411046-4 2017 In the present study, the effect of chlorpromazine, haloperidol and risperidone (0.5, 5 or 10muM) on production of pro-inflammatory cytokines IL-1beta and TNF-alpha and anti-inflammatory IL-10 was investigated in the unstimulated and lipopolysaccharide-stimulated primary rat mixed glial cell cultures. Risperidone 68-79 interleukin 1 beta Rattus norvegicus 142-150 28659745-8 2017 Interestingly, dietary tea polyphenols decreased the serum levels of pro-inflammatory factors (TNF-alpha: 13%, p < 0.05; IL-1beta: 10%, p < 0.05; and IL-6: 48%, p < 0.05) and shifted the serum IL-10/TNF-alpha ratio to a predominantly anti-inflammatory milieu (0.52 +- 0.07 vs. 0.67 +- 0.10, p < 0.01). Polyphenols 27-38 interleukin 1 beta Rattus norvegicus 124-132 28659745-9 2017 Furthermore, the polyphenols effectively inhibited the release of tissue damage markers (CK: 24%, p < 0.05 and LDH: 28%, p < 0.05) in the serum and decreased IL-1beta mRNA expression in the liver. Polyphenols 17-28 interleukin 1 beta Rattus norvegicus 164-172 28391159-8 2017 Moreover, quercetin regulated inflammation factors and hepatic stellate cells (HSCs)-activation markers, such as TNF-alpha, IL-6, IL-1beta, Cox-2, TGF-beta, alpha-SMA, Colla1, Colla2, TIMP-1, MMP-1, and desmin. Quercetin 10-19 interleukin 1 beta Rattus norvegicus 130-138 28761430-8 2017 These results suggest that deferoxamine decreases total iron ion, tumor necrosis factor-alpha, interleukin-1beta, and caspase-3 expression levels after spinal cord injury and inhibits apoptosis and glial scar formation to promote motor function recovery. Deferoxamine 27-39 interleukin 1 beta Rattus norvegicus 95-112 28298306-6 2017 Moreover, we found that the expression of miR-372 was stimulated in hNSC by IL-1beta through an NF-kappaB binding site at its promoter region. mir-372 42-49 interleukin 1 beta Rattus norvegicus 76-84 28298306-7 2017 Finally, stable overexpression of miR-372 inhibitor in hNSC rescued the IL-1beta-induced impairment as shown by significant improvements in tissue water content, myeloperoxidase activity, and behavioral assessments in SCI rats. mir-372 34-41 interleukin 1 beta Rattus norvegicus 72-80 28298306-7 2017 Finally, stable overexpression of miR-372 inhibitor in hNSC rescued the IL-1beta-induced impairment as shown by significant improvements in tissue water content, myeloperoxidase activity, and behavioral assessments in SCI rats. Water 147-152 interleukin 1 beta Rattus norvegicus 72-80 28298306-8 2017 These findings suggest a critical role of miR-372 in inflammatory signaling and pinpoint a novel target for the treatment of acute SCI.NEW & NOTEWORTHY Our data demonstrate that IL-1beta can impair the functional recovery of neural stem cell transplant therapy for spinal cord injury (SCI) treatment in rats. mir-372 42-49 interleukin 1 beta Rattus norvegicus 182-190 28298306-8 2017 These findings suggest a critical role of miR-372 in inflammatory signaling and pinpoint a novel target for the treatment of acute SCI.NEW & NOTEWORTHY Our data demonstrate that IL-1beta can impair the functional recovery of neural stem cell transplant therapy for spinal cord injury (SCI) treatment in rats. Adenosine Monophosphate 140-143 interleukin 1 beta Rattus norvegicus 182-190 27690698-0 2017 Allopurinol Protective Effect of Renal Ischemia by Downregulating TNF-alpha, IL-1beta, and IL-6 Response. Allopurinol 0-11 interleukin 1 beta Rattus norvegicus 77-85 27690698-3 2017 The objective of this study was to define the role of allopurinol regarding kidney ischemic injury particularly as to its effect on inflammatory molecules such as TNF-alpha, IL-1beta, and IL-6 response. Allopurinol 54-65 interleukin 1 beta Rattus norvegicus 174-182 27690698-12 2017 In conclusion, Allopurinol protected ischemic kidneys through a mechanism associated with downregulation of TNF-alpha, IL-1 beta, and IL-6, in addition to other well-known effects such as decreased lipid peroxidation and neutrophil activity. Allopurinol 15-26 interleukin 1 beta Rattus norvegicus 119-128 27473778-10 2017 Gene expression levels of inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-1beta, were significantly downregulated in the EGCG group (1.82 +- 0.71 vs 0.97 +- 0.59 [P < .05] and 3.91 +- 3.24 vs 0.89 +- 0.59 [P < .05], respectively). epigallocatechin gallate 151-155 interleukin 1 beta Rattus norvegicus 92-109 28378512-4 2017 5-FU induced significant weight loss, shortened villi height, and increased histological severity, IL-1beta expression, and MPO activity compared to the normal control group. Fluorouracil 0-4 interleukin 1 beta Rattus norvegicus 99-107 28245954-9 2017 In addition, Ceftriaxone also attenuated the marked increase of NFkappaB, TNF-alpha and IL-1beta in MPTP treated rats thus, conferring its neuro-inflammatory property. Ceftriaxone 13-24 interleukin 1 beta Rattus norvegicus 88-96 28601316-13 2017 RESULTS: Serum aspartate aminotransferase, alanine aminotransferase, IL-1beta, and IL-6 levels were significantly lower in the cilostazol group than in the saline group. Cilostazol 127-137 interleukin 1 beta Rattus norvegicus 69-77 28245954-9 2017 In addition, Ceftriaxone also attenuated the marked increase of NFkappaB, TNF-alpha and IL-1beta in MPTP treated rats thus, conferring its neuro-inflammatory property. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 100-104 interleukin 1 beta Rattus norvegicus 88-96 28430592-4 2017 The results demonstrated that resveratrol significantly improved the renal function and tubular epithelial cell injury and enhanced the survival rate of CLP-induced rat model of sepsis, which was accompanied by a substantial decrease of the serum content and renal mRNA expressions of TNF-alpha, IL-1beta and IL-6. Resveratrol 30-41 interleukin 1 beta Rattus norvegicus 296-304 28389372-11 2017 CONCLUSIONS: aPDT with curcumin PS 500mg/L demonstrated biocompatibility similar to saline solution and induced the IL-1beta and IL-6 cytokines production. curcumin ps 23-34 interleukin 1 beta Rattus norvegicus 116-124 28410798-6 2017 CoQ10 or L-carnitine showed a noticeable effects in improving cardiac functions evidenced reducing serum enzymes as serum interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), leptin, lactate dehydrogenase (LDH), Cardiotrophin-1, Troponin-I and Troponin-T. Also, alleviate oxidative stress, decrease of cardiac Malondialdehyde (MDA), Nitric oxide (NO) and restoring cardiac reduced glutathione levels to normal levels. coenzyme Q10 0-5 interleukin 1 beta Rattus norvegicus 122-140 28410798-6 2017 CoQ10 or L-carnitine showed a noticeable effects in improving cardiac functions evidenced reducing serum enzymes as serum interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), leptin, lactate dehydrogenase (LDH), Cardiotrophin-1, Troponin-I and Troponin-T. Also, alleviate oxidative stress, decrease of cardiac Malondialdehyde (MDA), Nitric oxide (NO) and restoring cardiac reduced glutathione levels to normal levels. coenzyme Q10 0-5 interleukin 1 beta Rattus norvegicus 142-151 28410798-6 2017 CoQ10 or L-carnitine showed a noticeable effects in improving cardiac functions evidenced reducing serum enzymes as serum interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), leptin, lactate dehydrogenase (LDH), Cardiotrophin-1, Troponin-I and Troponin-T. Also, alleviate oxidative stress, decrease of cardiac Malondialdehyde (MDA), Nitric oxide (NO) and restoring cardiac reduced glutathione levels to normal levels. Carnitine 9-20 interleukin 1 beta Rattus norvegicus 122-140 28410798-6 2017 CoQ10 or L-carnitine showed a noticeable effects in improving cardiac functions evidenced reducing serum enzymes as serum interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), leptin, lactate dehydrogenase (LDH), Cardiotrophin-1, Troponin-I and Troponin-T. Also, alleviate oxidative stress, decrease of cardiac Malondialdehyde (MDA), Nitric oxide (NO) and restoring cardiac reduced glutathione levels to normal levels. Carnitine 9-20 interleukin 1 beta Rattus norvegicus 142-151 28319836-2 2017 These manifest as increased interleukin (IL)-6 and IkappaBalpha, and suppressed IL-1beta and tumor necrosis factor alpha during acute ethanol intoxication. Ethanol 134-141 interleukin 1 beta Rattus norvegicus 80-88 28492224-3 2017 Here we show that concentrations of ATP and adenosine, its metabolite, fall after treatment of mouse chondrocytes and rat tibia explants with IL-1beta, an inflammatory mediator thought to participate in OA pathogenesis. Adenosine Triphosphate 36-39 interleukin 1 beta Rattus norvegicus 142-150 28579828-10 2017 Our results show that quercetin suppresses prenatal stress-induced pro-inflammatory marker (interleukin 1 beta) levels, subsequently attenuating febrile seizures. Quercetin 22-31 interleukin 1 beta Rattus norvegicus 92-110 28492224-3 2017 Here we show that concentrations of ATP and adenosine, its metabolite, fall after treatment of mouse chondrocytes and rat tibia explants with IL-1beta, an inflammatory mediator thought to participate in OA pathogenesis. Adenosine 44-53 interleukin 1 beta Rattus norvegicus 142-150 28522995-12 2017 The results showed that compared with those of normal-lipid ANP (NANP) groups, the HANP groups had more severe histopathological injuries in pancreas and distal ileum, aggravated intestinal barrier dysfunction and increased TNFalpha, IL-1beta, and IL-17A expression in plasma and distal ileum. hanp 83-87 interleukin 1 beta Rattus norvegicus 234-242 29926585-1 2017 OBJECTIVE: To evaluate the effects and mechanism of the Dexmedetomidine on the levels of proinflammatory mediators interleukin 1 beta (IL-1beta) and tumor necrosis factor-alpha(TNF-alpha) in ischemia/reperfusion(I/R)rats. Dexmedetomidine 56-71 interleukin 1 beta Rattus norvegicus 115-133 29926585-1 2017 OBJECTIVE: To evaluate the effects and mechanism of the Dexmedetomidine on the levels of proinflammatory mediators interleukin 1 beta (IL-1beta) and tumor necrosis factor-alpha(TNF-alpha) in ischemia/reperfusion(I/R)rats. Dexmedetomidine 56-71 interleukin 1 beta Rattus norvegicus 135-143 29926585-7 2017 Compared with I/R Atip Dex+Atip group, the levels of W/D TLW,IL-1beta and TNF-alpha in Dex group were lower (P<0.05), the structure damages of lung tissues observed under light microscopy and electron microscope in Dex group were slighter. Dextromethorphan 23-26 interleukin 1 beta Rattus norvegicus 61-69 29926585-7 2017 Compared with I/R Atip Dex+Atip group, the levels of W/D TLW,IL-1beta and TNF-alpha in Dex group were lower (P<0.05), the structure damages of lung tissues observed under light microscopy and electron microscope in Dex group were slighter. atip 27-31 interleukin 1 beta Rattus norvegicus 61-69 29926585-7 2017 Compared with I/R Atip Dex+Atip group, the levels of W/D TLW,IL-1beta and TNF-alpha in Dex group were lower (P<0.05), the structure damages of lung tissues observed under light microscopy and electron microscope in Dex group were slighter. Dextromethorphan 87-90 interleukin 1 beta Rattus norvegicus 61-69 29926585-7 2017 Compared with I/R Atip Dex+Atip group, the levels of W/D TLW,IL-1beta and TNF-alpha in Dex group were lower (P<0.05), the structure damages of lung tissues observed under light microscopy and electron microscope in Dex group were slighter. Dextromethorphan 87-90 interleukin 1 beta Rattus norvegicus 61-69 29926585-9 2017 CONCLUSIONS: Dexmedetomidine can alleviate ischemia/reperfusion injury in rat lung through lowering the level of proinflammatory mediators IL-1beta and TNF-alpha,the possible mechanism may be through stimulation of alpha2 adrenaline receptors. Dexmedetomidine 13-28 interleukin 1 beta Rattus norvegicus 139-147 26857094-5 2017 OEA reduced the levels of interleukin-1beta (IL-1beta), the monocyte chemoattractant protein-1 (MCP-1), and the enzymes cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in ethanol binged animals. oleoylethanolamide 0-3 interleukin 1 beta Rattus norvegicus 26-43 28260798-8 2017 Geniposide or SASP suppressed inflammatory cytokine (TNF-alpha, IL-1beta, and IL-6) release and neutrophil infiltration (myeloperoxidase activity) in the colon. geniposide 0-10 interleukin 1 beta Rattus norvegicus 64-72 26857094-5 2017 OEA reduced the levels of interleukin-1beta (IL-1beta), the monocyte chemoattractant protein-1 (MCP-1), and the enzymes cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in ethanol binged animals. oleoylethanolamide 0-3 interleukin 1 beta Rattus norvegicus 45-53 26857094-6 2017 Elevations in plasma tumor necrosis factor alpha (TNF-alpha) and IL-1beta after ethanol were also inhibited by OEA. Ethanol 80-87 interleukin 1 beta Rattus norvegicus 65-73 28190546-12 2017 Sevoflurane treatment reduced levels of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha. Sevoflurane 0-11 interleukin 1 beta Rattus norvegicus 40-57 28561222-8 2017 The results showed that lung HP level as well as IL-1beta, TNF-alpha and IL-8 were significantly lower in the CS treated rats as compared to PQ group. Cromolyn Sodium 110-112 interleukin 1 beta Rattus norvegicus 49-57 28214689-9 2017 Moreover, paeoniflorin significantly reduced the over expressions of NF-kappaB and IL-1beta induced by ANIT in liver tissue. peoniflorin 10-22 interleukin 1 beta Rattus norvegicus 83-91 28647186-6 2017 There were also marked and significant inhibition of brain PON-1 and BChE activities and increased Il-1beta in brain of rotenone-treated rats. Rotenone 120-128 interleukin 1 beta Rattus norvegicus 99-107 28357802-6 2017 The sera interleukin (IL)-1beta, tumor necrosis factor (TNF-alpha), and IL-10, liver transaminase, urea, creatinine, and peripheral neutrophil count were significantly increased in Cd-exposed rats compared to the control group. Cadmium 181-183 interleukin 1 beta Rattus norvegicus 9-31 28257878-3 2017 High glucose stimulated the production of reactive oxygen species (ROS), nicotinamide adenine dinucleotide phosphate oxidase (NOX), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1) production. Glucose 5-12 interleukin 1 beta Rattus norvegicus 132-149 28565823-0 2017 Corticosterone suppresses IL-1beta-induced mPGE2 expression through regulation of the 11beta-HSD1 bioactivity of synovial fibroblasts in vitro. Corticosterone 0-14 interleukin 1 beta Rattus norvegicus 26-34 28565823-6 2017 Corticosterone was demonstrated to suppress the mRNA expression levels of inflammatory factors, such as TNF-alpha and PGE2, induced by IL-1beta in vitro. Corticosterone 0-14 interleukin 1 beta Rattus norvegicus 135-143 28565823-6 2017 Corticosterone was demonstrated to suppress the mRNA expression levels of inflammatory factors, such as TNF-alpha and PGE2, induced by IL-1beta in vitro. Dinoprostone 118-122 interleukin 1 beta Rattus norvegicus 135-143 28257878-3 2017 High glucose stimulated the production of reactive oxygen species (ROS), nicotinamide adenine dinucleotide phosphate oxidase (NOX), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1) production. Glucose 5-12 interleukin 1 beta Rattus norvegicus 151-159 28565759-13 2017 Similar to pranlukast, AMP also inhibited the MCAO-induced IL-1beta and TNF-alpha release. ampelopsin 23-26 interleukin 1 beta Rattus norvegicus 59-67 28565773-11 2017 Furthermore, CCl4-mediated increases in the inflammatory factors tumor necrosis factor-alpha and interleukin-1beta secretion into the serum and their expression in liver tissues were reversed following GB treatment, as revealed by ELISA and PCR, respectively. gb 202-204 interleukin 1 beta Rattus norvegicus 97-114 28188686-4 2017 Furthermore, immunological dysfunction caused by TiO2 NPs was involved in the increased expression of NF-kappaB, TNF-alpha, and IL-1beta, and decreased IkappaB expression. titanium dioxide 49-53 interleukin 1 beta Rattus norvegicus 128-136 27881606-2 2017 Damaged mitochondria release danger molecules, such as reactive oxygen species, DNA, and cardiolipin, which can cause NLRP3 inflammasome activation and upregulation of IL-18 and IL-1beta It is not known if mitochondrial damage persists long after ischemia to sustain chronic inflammasome activation. Reactive Oxygen Species 55-78 interleukin 1 beta Rattus norvegicus 178-186 27635524-4 2017 CIH rats treated with infliximab further increased TNF-alpha, IL-1beta, IL-6, and interferon-gamma diaphragm levels, whereas NAC induced a reduction only in TNF-alpha and IL-1beta levels in diaphragm and plasma. cih 0-3 interleukin 1 beta Rattus norvegicus 171-179 27635524-4 2017 CIH rats treated with infliximab further increased TNF-alpha, IL-1beta, IL-6, and interferon-gamma diaphragm levels, whereas NAC induced a reduction only in TNF-alpha and IL-1beta levels in diaphragm and plasma. Acetylcysteine 125-128 interleukin 1 beta Rattus norvegicus 171-179 27635524-3 2017 Compared to non-exposed controls, in CIH-exposed rats, body weight gain was reduced, TNF-alpha, IL-1beta, IL-6, and interferon-gamma levels were increased in diaphragm, TNF-alpha, and IL-1 beta plasma levels were greater, systemic and muscle superoxide anion production was higher, diaphragm and gastrocnemius inflammatory cells and internal nuclei were higher, and muscle fiber-type and morphometry remained unmodified. cih 37-40 interleukin 1 beta Rattus norvegicus 96-104 27635524-3 2017 Compared to non-exposed controls, in CIH-exposed rats, body weight gain was reduced, TNF-alpha, IL-1beta, IL-6, and interferon-gamma levels were increased in diaphragm, TNF-alpha, and IL-1 beta plasma levels were greater, systemic and muscle superoxide anion production was higher, diaphragm and gastrocnemius inflammatory cells and internal nuclei were higher, and muscle fiber-type and morphometry remained unmodified. cih 37-40 interleukin 1 beta Rattus norvegicus 184-193 27635524-4 2017 CIH rats treated with infliximab further increased TNF-alpha, IL-1beta, IL-6, and interferon-gamma diaphragm levels, whereas NAC induced a reduction only in TNF-alpha and IL-1beta levels in diaphragm and plasma. cih 0-3 interleukin 1 beta Rattus norvegicus 62-70 27982724-11 2017 Moreover, in the LPS and ligature-induced periodontitis rat model, BTZ suppressed expression of TNF-alpha, IL-1beta, IL-6, and IL-8, reduced the ratio of receptor activator of NF-kappaB ligand/osteoprotegerin, and prevented alveolar bone absorption. Bortezomib 67-70 interleukin 1 beta Rattus norvegicus 107-115 28359852-12 2017 Alone doses of lithium and memantine or the association of lithium and memantine caused reductions in the levels of IL-1beta in the frontal cortex and hippocampus, and decreased the levels of TNF-alpha in the hippocampus. Lithium 15-22 interleukin 1 beta Rattus norvegicus 116-124 28359852-12 2017 Alone doses of lithium and memantine or the association of lithium and memantine caused reductions in the levels of IL-1beta in the frontal cortex and hippocampus, and decreased the levels of TNF-alpha in the hippocampus. Memantine 27-36 interleukin 1 beta Rattus norvegicus 116-124 28359852-12 2017 Alone doses of lithium and memantine or the association of lithium and memantine caused reductions in the levels of IL-1beta in the frontal cortex and hippocampus, and decreased the levels of TNF-alpha in the hippocampus. Lithium 59-66 interleukin 1 beta Rattus norvegicus 116-124 28359852-12 2017 Alone doses of lithium and memantine or the association of lithium and memantine caused reductions in the levels of IL-1beta in the frontal cortex and hippocampus, and decreased the levels of TNF-alpha in the hippocampus. Memantine 71-80 interleukin 1 beta Rattus norvegicus 116-124 28353366-9 2017 Interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha mRNA expression were significantly lower in the 5-FU plus selenium group than in the 5-FU only group (IL-1beta, P < 0.01; TNF-alpha, P < 0.05). Fluorouracil 109-113 interleukin 1 beta Rattus norvegicus 0-22 28353366-9 2017 Interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha mRNA expression were significantly lower in the 5-FU plus selenium group than in the 5-FU only group (IL-1beta, P < 0.01; TNF-alpha, P < 0.05). Selenium 119-127 interleukin 1 beta Rattus norvegicus 0-22 28353366-9 2017 Interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha mRNA expression were significantly lower in the 5-FU plus selenium group than in the 5-FU only group (IL-1beta, P < 0.01; TNF-alpha, P < 0.05). Selenium 119-127 interleukin 1 beta Rattus norvegicus 163-171 27634381-11 2017 Quercetin significantly reduced the levels of blood insulin, interleukin 1beta, IL-6, and tumor necrosis factor alpha. Quercetin 0-9 interleukin 1 beta Rattus norvegicus 61-78 28214521-9 2017 The I/R-induced pro-inflammatory mediator mRNA and protein overexpression in the penumbra cortex, including ICAM-1, IL-1beta, IL-6, IL-8, and MCP-1, were significantly inhibited by SAB in a dose-dependent manner. salvianolic acid B 181-184 interleukin 1 beta Rattus norvegicus 116-124 28263009-10 2017 MAPC treatment restored spleen mass reduction caused by stroke, elevated Treg cells within the spleen, increased IL-10 and decreased IL-1beta released by splenocytes. mapc 0-4 interleukin 1 beta Rattus norvegicus 133-141 28263009-11 2017 MAPC reduced IL-6 and IL-1beta and upregulated IL-10 serum levels. mapc 0-4 interleukin 1 beta Rattus norvegicus 22-30 28729914-5 2017 Blocking mTOR using rapamycin attenuated upregulation of pro-inflammatory cytokines (namely IL-1beta, IL-6 and TNF-alpha), and Caspase-3, indicating cell apoptosis and also promoting the levels of vascular endothelial growth factor (VEGF) and its subtype receptor VEGFR-2 in the hippocampus. Sirolimus 20-29 interleukin 1 beta Rattus norvegicus 92-100 28491822-5 2017 Our results show that BoNT/A and minocycline influenced primary microglial cells by inhibiting intracellular signaling pathways, such as p38, ERK1/2, NF-kappaB, and the release of pro-inflammatory factors, including IL-1beta, IL-18, IL-6, and NOS2. bont 22-26 interleukin 1 beta Rattus norvegicus 216-224 28491822-5 2017 Our results show that BoNT/A and minocycline influenced primary microglial cells by inhibiting intracellular signaling pathways, such as p38, ERK1/2, NF-kappaB, and the release of pro-inflammatory factors, including IL-1beta, IL-18, IL-6, and NOS2. Minocycline 33-44 interleukin 1 beta Rattus norvegicus 216-224 28458629-7 2017 The results showed that SNI produced mechanical allodynia and depressive-like behaviors, and also increased the expressions of microglia markers (Iba1, CD11b) and M1 markers (CD68, iNOS, IL-1beta, TNF-alpha, and 8-OH-dG) in the prefrontal cortex. sni 24-27 interleukin 1 beta Rattus norvegicus 187-195 28092020-9 2017 Interestingly, treatment with minocycline to block microglial activation induced by ESI inhibited increases in hippocampal microglia and prevented ESI-induced depressive-like behavior as well as increases in IL-1beta, IL-6, and TNF-alpha. Minocycline 30-41 interleukin 1 beta Rattus norvegicus 208-216 28302538-6 2017 Garcinol suppressed microglial activation as well as the expression of interleukin (IL)-1beta, IL-6, inducible nitric oxide synthase (iNOS)/nitric oxide (NO), and cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) in the spinal cord of SNL rats. garcinol 0-8 interleukin 1 beta Rattus norvegicus 71-93 28321024-10 2017 We meanwhile confirmed that hexarelin induced down-regulation of IL-1beta expression and up-regulation of IL-1Ra expression in I/R myocardium, which could be neutralized by the GHSR antagonist [D-Lys3]-growth hormone releasing peptide-6 ([D-Lys3]-GHRP-6). hexarelin 28-37 interleukin 1 beta Rattus norvegicus 65-73 28903333-6 2017 Besides, Ro-32-0432 suppressed EAM-induced cardiac fibrosis and release of pro-inflammatory cytokines IL-1beta and IL-17. Ro 32-0432 9-19 interleukin 1 beta Rattus norvegicus 102-110 28465656-8 2017 RESULTS: The levels of NLRP3, ASC, cleaved caspase-1, IL-1beta, and IL-18 were upregulated in the retinas of the STZ-induced diabetic rats; however, these changes were partially inhibited by the RvD1 treatment. Streptozocin 113-116 interleukin 1 beta Rattus norvegicus 54-62 28104476-9 2017 Meanwhile, pretreatment with vit E or Omega-3 FA induced a significantly alleviation of the inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and the elevation of the anti-oxidative activity especially in the rats pretreated with combined vit E and Omega-3 FA. Vitamin E 29-34 interleukin 1 beta Rattus norvegicus 127-135 28216621-6 2017 Furthermore, pretreatment with RABE (3 mumol/L) markedly inhibited lipopolysaccharide (LPS)-induced increases in the release of TNF-alpha, IL-1beta, NO and PGE2, and the expression levels of iNOS, and COX-2 in cultured rat microglial cells. rosmarinic acid n-butyl ester 31-35 interleukin 1 beta Rattus norvegicus 139-147 28110193-15 2017 Melanin reduced the content of IL-1beta in rat serum and restored the level of anti-inflammatory cytokines (IL-10, TGF-beta) to the control values. Melanins 0-7 interleukin 1 beta Rattus norvegicus 31-39 28153540-10 2017 These data indicate the involvement of P2Y1Rs in IL-1beta mediated pain in both naive and carrageenan injected rats. Carrageenan 90-101 interleukin 1 beta Rattus norvegicus 49-57 28060522-9 2017 Cotreatment with aspirin and (or) omega-3 PUFAs reduced convulsive behaviour; reduced levels of LXA4, interleukin-1beta, and nuclear factor-kappaB; and showed a lower percentage of corticohippocampal degenerative cells compared to PTZ-kindled rats. Aspirin 17-24 interleukin 1 beta Rattus norvegicus 102-119 28060522-9 2017 Cotreatment with aspirin and (or) omega-3 PUFAs reduced convulsive behaviour; reduced levels of LXA4, interleukin-1beta, and nuclear factor-kappaB; and showed a lower percentage of corticohippocampal degenerative cells compared to PTZ-kindled rats. 3 pufas 40-47 interleukin 1 beta Rattus norvegicus 102-119 28104476-9 2017 Meanwhile, pretreatment with vit E or Omega-3 FA induced a significantly alleviation of the inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and the elevation of the anti-oxidative activity especially in the rats pretreated with combined vit E and Omega-3 FA. Fatty Acids, Omega-3 38-48 interleukin 1 beta Rattus norvegicus 127-135 28201924-2 2017 Acute ethanol intoxication significantly modulates several pro-inflammatory cytokines (e.g. interleukins-1 and 6 [IL-1beta and IL-6, respectively] and tumor necrosis factor alpha [TNFalpha])) in several brain areas, including amygdala (AMG), paraventricular nucleus (PVN), and hippocampus (HPC). Ethanol 6-13 interleukin 1 beta Rattus norvegicus 114-122 28199036-10 2017 STZ-induced increase in oxidative stress and increased levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta) were mitigated by edaravone. Streptozocin 0-3 interleukin 1 beta Rattus norvegicus 104-112 28199036-10 2017 STZ-induced increase in oxidative stress and increased levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta) were mitigated by edaravone. Edaravone 132-141 interleukin 1 beta Rattus norvegicus 104-112 28257293-12 2017 Minocycline pretreatment also significantly attenuated ischemia-induced pyramidal cell death and microglial activation in the CA1 region and reduced the levels of malondialdehyde and proinflammatory cytokines (interleukin-1beta and tumor necrosis factor-alpha) in the hippocampus of ischemic rats. Minocycline 0-11 interleukin 1 beta Rattus norvegicus 210-259 28077335-3 2017 Rats treated with omega-3 FAs had significantly less TBI-induced caspase-1 cleavage and IL-1beta secretion than those with vehicle. Fatty Acids, Omega-3 18-29 interleukin 1 beta Rattus norvegicus 88-96 28485787-9 2017 In PA-treated rats, the wet/dry weight ratios and the serum levels of TNF-a, IL-1beta and IL-6 were down-regulated compared with the CLP group. pachymic acid 3-5 interleukin 1 beta Rattus norvegicus 77-85 27739173-8 2017 Pretreatment of animals by ketamine, topiramate, and yohimbine inhibited the MPH-induced oxidative stress and inflammation; it significantly decreased lipid peroxidation, GSSG level, IL-1beta and TNF-alpha levels and increased GSH content, SOD, GPx, and GR activities in hippocampus and cerebral cortex of acutely MPH-treated rats. Ketamine 27-35 interleukin 1 beta Rattus norvegicus 183-191 27739173-8 2017 Pretreatment of animals by ketamine, topiramate, and yohimbine inhibited the MPH-induced oxidative stress and inflammation; it significantly decreased lipid peroxidation, GSSG level, IL-1beta and TNF-alpha levels and increased GSH content, SOD, GPx, and GR activities in hippocampus and cerebral cortex of acutely MPH-treated rats. Topiramate 37-47 interleukin 1 beta Rattus norvegicus 183-191 28485779-7 2017 Isoflurane increased the expression of interleukin 1beta (IL-1beta) and activated caspase 3 in the hippocampus, but not cortex of the rats. Isoflurane 0-10 interleukin 1 beta Rattus norvegicus 39-56 28485779-7 2017 Isoflurane increased the expression of interleukin 1beta (IL-1beta) and activated caspase 3 in the hippocampus, but not cortex of the rats. Isoflurane 0-10 interleukin 1 beta Rattus norvegicus 58-66 28485779-11 2017 At the same time, IL-1beta may play an important role in this isoflurane effect. Isoflurane 62-72 interleukin 1 beta Rattus norvegicus 18-26 28322346-4 2017 The cytokine assays showed that RSV could markedly decrease the production of proinflammatory mediators and cytokines (IL-1, IL-1beta, IL-6, NO, iNOS and COX-2), and increase the expression of anti-inflammatory mediator (IL-10). Resveratrol 32-35 interleukin 1 beta Rattus norvegicus 125-133 28485782-13 2017 Concomitantly, TNF-alpha, IL-6, and IL-1beta levels, which are indicators of immunological and informatory responses, were also decreased after NAC treatment. Acetylcysteine 144-147 interleukin 1 beta Rattus norvegicus 36-44 29069238-8 2017 Candesartan and aliskiren decreased IL-1beta, while only candesartan reduced TGF-beta and only aliskiren increased IL-10. candesartan 0-11 interleukin 1 beta Rattus norvegicus 36-44 29069238-8 2017 Candesartan and aliskiren decreased IL-1beta, while only candesartan reduced TGF-beta and only aliskiren increased IL-10. aliskiren 16-25 interleukin 1 beta Rattus norvegicus 36-44 27135637-11 2017 The immunoenzymatic assay of the gingival tissue showed a lower concentration of IL-1beta in the COMBI group in comparison with the PL group (p < 0.05). combi 97-102 interleukin 1 beta Rattus norvegicus 81-89 28089828-13 2017 Nitrite decreased elevated serum IL-1beta in diabetic rats (4.0 +- 0.2 vs. 2.9 +- 0.2 pg/mL, P = 0.001). Nitrites 0-7 interleukin 1 beta Rattus norvegicus 33-41 27739173-8 2017 Pretreatment of animals by ketamine, topiramate, and yohimbine inhibited the MPH-induced oxidative stress and inflammation; it significantly decreased lipid peroxidation, GSSG level, IL-1beta and TNF-alpha levels and increased GSH content, SOD, GPx, and GR activities in hippocampus and cerebral cortex of acutely MPH-treated rats. Yohimbine 53-62 interleukin 1 beta Rattus norvegicus 183-191 28189971-12 2017 Sulforaphane treatment inhibits NLRP3 inflammasome activation and the downregulation of cleaved caspase-1, while reducing IL-1beta and IL-18 expression. sulforaphane 0-12 interleukin 1 beta Rattus norvegicus 122-130 28189971-14 2017 This neuroprotective effect is likely exerted by Sulforaphane inhibited NLRP3 inflammasome activation caused by the downregulation of NLRP3, the induction of cleaved caspase-1, and thus the reduction of IL-1beta and IL-18. sulforaphane 49-61 interleukin 1 beta Rattus norvegicus 203-211 28804612-9 2017 Significant reduction of Nf-kappaB and IL-1beta, and increasing of SIRT1 were observed during genistein treatment (P<0.05). Genistein 94-103 interleukin 1 beta Rattus norvegicus 39-47 28282556-6 2017 Data showed that cisplatin caused elevation in serum creatinine and urea, disturbance in blood count, elevation in gene expression of tumor necrosis factor alpha, nuclear factor kappa B, interleukin-1beta, caspase-3, mitochondrial cytochrome C and apoptosis-inducing factor in renal tissue. Cisplatin 17-26 interleukin 1 beta Rattus norvegicus 187-204 27933551-9 2017 Treatment with PTX (60 mg/kg) significantly inhibited the protein expressions of TLR4, NF-kappaB, MyD88 and the downstream pro-inflammatory cytokines, such as the tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). Pentoxifylline 15-18 interleukin 1 beta Rattus norvegicus 207-224 27933551-9 2017 Treatment with PTX (60 mg/kg) significantly inhibited the protein expressions of TLR4, NF-kappaB, MyD88 and the downstream pro-inflammatory cytokines, such as the tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). Pentoxifylline 15-18 interleukin 1 beta Rattus norvegicus 226-234 28355351-7 2017 Moreover, the effect of naringenin was also studied in vitro in IL-1beta activated articular chondrocytes. naringenin 24-34 interleukin 1 beta Rattus norvegicus 64-72 28185984-6 2017 The levels of MAP, HR, plasma norepinephrine (NE), reactive oxygen species (ROS), NOX2, NOX4 and IL-1beta were increased significantly in high salt-induced hypertensive rats. Salts 143-147 interleukin 1 beta Rattus norvegicus 97-105 28435433-10 2017 SOD activity, NGF, and bcl-2 were significantly increased, while IL-1beta was significantly decreased after melatonin treatment as compared to the untreated injury group. Melatonin 108-117 interleukin 1 beta Rattus norvegicus 65-73 29806266-9 2017 MTT assay showed that IL-1beta and Melittin could inhibit the EPCs in a dose-dependent manner after intervention of 24 and 48 hours, and the optimal concentrations of IL-1beta and Melittin intervention were 10 ng/mL and 1.0 mug/mL respectively. monooxyethylene trimethylolpropane tristearate 0-3 interleukin 1 beta Rattus norvegicus 22-30 29806266-9 2017 MTT assay showed that IL-1beta and Melittin could inhibit the EPCs in a dose-dependent manner after intervention of 24 and 48 hours, and the optimal concentrations of IL-1beta and Melittin intervention were 10 ng/mL and 1.0 mug/mL respectively. monooxyethylene trimethylolpropane tristearate 0-3 interleukin 1 beta Rattus norvegicus 167-175 28287423-7 2017 Ginsenoside Rg1 inhibited Interleukin (IL)-1beta-induced chondrocyte gene and protein expressions of MMP-13, COX-2 and PGE2, and prevented type II collagen and aggrecan degradation, in a dose-dependent manner. Ginsenosides 0-11 interleukin 1 beta Rattus norvegicus 26-48 28287423-7 2017 Ginsenoside Rg1 inhibited Interleukin (IL)-1beta-induced chondrocyte gene and protein expressions of MMP-13, COX-2 and PGE2, and prevented type II collagen and aggrecan degradation, in a dose-dependent manner. Dinoprostone 119-123 interleukin 1 beta Rattus norvegicus 26-48 28211272-4 2017 In in vitro examinations, RAW264.7 macrophages grown on PCLF/DMOG meshes enhance the expression of growth factors (IGF-1, HB-EGF, and NGF) and anti-inflammatory factors (TGF-beta1 and IL-4) but decrease that of pro-inflammatory factors (IL-1beta and IL-6). pclf 56-60 interleukin 1 beta Rattus norvegicus 237-245 28211272-4 2017 In in vitro examinations, RAW264.7 macrophages grown on PCLF/DMOG meshes enhance the expression of growth factors (IGF-1, HB-EGF, and NGF) and anti-inflammatory factors (TGF-beta1 and IL-4) but decrease that of pro-inflammatory factors (IL-1beta and IL-6). oxalylglycine 61-65 interleukin 1 beta Rattus norvegicus 237-245 28272417-6 2017 Compared with those in the DM + MCAO group, rats in the DM + MCAO + TAK242 group exhibited an increase in SOD activity and a decrease in cell apoptosis, expression of Bcl-2, Bax, cleaved caspase-3, TNF-alpha, IL-1beta and TLR4 proteins and MDA content. dm 56-58 interleukin 1 beta Rattus norvegicus 209-217 28272417-6 2017 Compared with those in the DM + MCAO group, rats in the DM + MCAO + TAK242 group exhibited an increase in SOD activity and a decrease in cell apoptosis, expression of Bcl-2, Bax, cleaved caspase-3, TNF-alpha, IL-1beta and TLR4 proteins and MDA content. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 68-74 interleukin 1 beta Rattus norvegicus 209-217 28199982-9 2017 NAC inhibited the cleavage of IL-1beta in DRGs, which is a critical substrate of MMP-9, and markedly suppressed glial activation and neuron excitability in spinal dorsal horn induced by remifentanil. Acetylcysteine 0-3 interleukin 1 beta Rattus norvegicus 30-38 28435433-11 2017 SFI reached the control level; muscle contraction and IL-1B were significantly improved in the group treated with melatonin in the dark. Melatonin 114-123 interleukin 1 beta Rattus norvegicus 54-59 28072457-2 2017 The present study investigated the effects of binge-like EtOH exposure in adolescent rats on the febrile response that was induced by lipopolysaccharide (LPS) and interleukin-1beta (IL-1beta). Ethanol 57-61 interleukin 1 beta Rattus norvegicus 163-180 28072457-9 2017 The febrile response that was induced by intracerebroventricular IL-1beta also significantly decreased in animals that received binge-like EtOH exposure during adolescence. Ethanol 139-143 interleukin 1 beta Rattus norvegicus 65-73 28261302-8 2017 Pretreatment with paricalcitol decreased the levels of pro-inflammatory mediators, such as interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and macrophage migration inhibitory factor (MIF), in both plasma and liver tissue. paricalcitol 18-30 interleukin 1 beta Rattus norvegicus 91-113 28348965-6 2017 RESULTS: Plasma levels of TNF-alpha and IL-1beta were found to be non-detectable in control and groups treated with 500 and 1000 mg/kg of stevioside. stevioside 138-148 interleukin 1 beta Rattus norvegicus 40-48 28348965-8 2017 Additionally, IL-1beta levels in rats treated with 500 and 1000 mg/kg of stevioside were significantly different (p<0.05) from those in LPS-treated control group (220.0+12.1 and 158.1 + 22.6 vs 294.4+16.1 pg/ml). stevioside 73-83 interleukin 1 beta Rattus norvegicus 14-22 28348965-9 2017 CONCLUSION: Consumption of stevioside has an inhibitory effect on the release of TNF-alpha and IL-1beta from LPS-stimulated PBMCs in rats. stevioside 27-37 interleukin 1 beta Rattus norvegicus 95-103 28095363-15 2017 Also, alcohol administration augmented lipid peroxidation, mitochondrial oxidized glutathione (GSSG), interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and Bax levels in isolated hippocampal tissues. Alcohols 6-13 interleukin 1 beta Rattus norvegicus 102-120 28188848-11 2017 Moreover, 3-MA increased the apoptosis and the expression of TNF-alpha, IL-1beta, and MMP-9. 3-methyladenine 10-14 interleukin 1 beta Rattus norvegicus 72-80 28011263-7 2017 Sciatic nerves from CCI rats revealed that PAE potentiated the proinflammatory cytokines interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha (TNFalpha) protein levels with a simultaneous robust suppression of the anti-inflammatory cytokine, IL-10. 2-(Isopropylamino)ethanol 43-46 interleukin 1 beta Rattus norvegicus 89-111 28068647-4 2017 Subsequently, western blot analysis revealed that berberine decreased the protein expression of IL-1beta and caspase 1 and increased Nrf2 expression in RAW 264.7 macrophages. Berberine 50-59 interleukin 1 beta Rattus norvegicus 96-104 28364439-9 2017 Similarly, pro-inflammatory cytokine levels (interleukin-1beta and interleukin-6) in the left lung were significantly lower in the hydrogen-rich saline group than in the normal saline group ( P < 0.05). Hydrogen 131-139 interleukin 1 beta Rattus norvegicus 45-62 28068647-2 2017 Our results indicate that berberine (25, 50 and 75muM) suppressed the levels of pro-inflammatory cytokines (interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha)) and intracellular reactive oxygen species in MSU crystal stimulated RAW 264.7 macrophages. Berberine 26-35 interleukin 1 beta Rattus norvegicus 108-125 28068647-2 2017 Our results indicate that berberine (25, 50 and 75muM) suppressed the levels of pro-inflammatory cytokines (interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha)) and intracellular reactive oxygen species in MSU crystal stimulated RAW 264.7 macrophages. Berberine 26-35 interleukin 1 beta Rattus norvegicus 127-135 28092862-13 2017 Furthermore, TFA significantly inhibited serum TNF-alpha, IL-1beta, PGE2 and RANKL production, and promoted serum OPG production and OPG/RANKL ratio of rats induced by FCA. Trifluoroacetic Acid 13-16 interleukin 1 beta Rattus norvegicus 58-66 28068647-6 2017 In addition, the paw edema, pain score, pro-inflammatory cytokines (IL-1beta and TNFalpha) and articular elastase activity were found significantly reduced in berberine (50mg/kgb wt) administered MSU crystal-induced rats. Berberine 159-168 interleukin 1 beta Rattus norvegicus 68-76 28025796-9 2017 Exogenous IFN-gamma, TNF-alpha, and IL-1beta enhanced superoxide, ROS, and XO in the PMNs of control and MB+PQ-treated rats; however, IFN- gamma was found to be the most potent inducer. Superoxides 54-64 interleukin 1 beta Rattus norvegicus 36-44 28196290-5 2017 Enzyme-linked immunosorbent assay (ELISA) and real-time quantitative polymerase chain reaction (qRT-PCR) showed that curcumin could reduce c-reaction protein levels and inflammatory cytokine (TNF-alpha, IL-1beta, IL-6, and CINC-1/IL-8) concentrations in peripheral serum and liver tissue. Curcumin 117-125 interleukin 1 beta Rattus norvegicus 203-211 28450945-11 2017 Furthermore, reverse transcription-quantitative polymerase chain reaction analysis was performed to analyze the expression levels of inflammatory cytokines, which demonstrated that bupivacaine significantly inhibited the expression of TNF-alpha, IL-1beta and IL-6, as compared with the untreated group (P<0.01). Bupivacaine 181-192 interleukin 1 beta Rattus norvegicus 246-254 28025796-9 2017 Exogenous IFN-gamma, TNF-alpha, and IL-1beta enhanced superoxide, ROS, and XO in the PMNs of control and MB+PQ-treated rats; however, IFN- gamma was found to be the most potent inducer. Reactive Oxygen Species 66-69 interleukin 1 beta Rattus norvegicus 36-44 28098910-5 2017 H2-rich saline improved fasting blood glucose, fasting insulin, insulin sensitivity and glucose tolerance, and lowered the expression levels of tumor necrosis factor alpha, interleukin-1 beta, 3-nitrotyrosine and 8-hydroxy-2"-deoxyguanosine in the liver. Hydrogen 0-2 interleukin 1 beta Rattus norvegicus 173-191 28098910-5 2017 H2-rich saline improved fasting blood glucose, fasting insulin, insulin sensitivity and glucose tolerance, and lowered the expression levels of tumor necrosis factor alpha, interleukin-1 beta, 3-nitrotyrosine and 8-hydroxy-2"-deoxyguanosine in the liver. Sodium Chloride 8-14 interleukin 1 beta Rattus norvegicus 173-191 28025796-9 2017 Exogenous IFN-gamma, TNF-alpha, and IL-1beta enhanced superoxide, ROS, and XO in the PMNs of control and MB+PQ-treated rats; however, IFN- gamma was found to be the most potent inducer. mb+pq 105-110 interleukin 1 beta Rattus norvegicus 36-44 28214085-0 2017 Folic acid protects against lead acetate-induced hepatotoxicity by decreasing NF-kappaB, IL-1beta production and lipid peroxidation mediataed cell injury. Folic Acid 0-10 interleukin 1 beta Rattus norvegicus 89-97 28112382-8 2017 The levels of interleukin-1beta, tumor necrosis factor-alpha, nitric oxide and inducible nitric oxide synthetase were reduced by 67, 54, 32 ad 49%, respectively after one month of treatment with 15 mg/kg dose of ginsenoside-Rg5. ginsenoside Rg5 212-227 interleukin 1 beta Rattus norvegicus 14-60 28214085-0 2017 Folic acid protects against lead acetate-induced hepatotoxicity by decreasing NF-kappaB, IL-1beta production and lipid peroxidation mediataed cell injury. lead acetate 28-40 interleukin 1 beta Rattus norvegicus 89-97 28214085-13 2017 In conclusion, folic acid protects against lead acetate-induced hepatotoxicity by decreasing NF-kappaB, IL-1beta production and lipid peroxidation mediataed cell injury. Folic Acid 15-25 interleukin 1 beta Rattus norvegicus 104-112 28093813-7 2017 Nerolidol notably inhibited the increase of TNFalpha and IL-1beta in LPS-treated rats and the mRNA expression of TNFalpha and IL-1beta in LPS-treated NRK-52E cells. nerolidol 0-9 interleukin 1 beta Rattus norvegicus 57-65 28093813-7 2017 Nerolidol notably inhibited the increase of TNFalpha and IL-1beta in LPS-treated rats and the mRNA expression of TNFalpha and IL-1beta in LPS-treated NRK-52E cells. nerolidol 0-9 interleukin 1 beta Rattus norvegicus 126-134 28093813-9 2017 Overexpression of TLR4 and p65 NF-kappaB significantly suppressed nerolidol-induced inhibition of TNFalpha and IL-1beta expression and increase of cell viability in LPS-treated cells. nerolidol 66-75 interleukin 1 beta Rattus norvegicus 111-119 28249154-6 2017 Consistent with reduced gouty flares in rats fed a ketogenic diet, BHB blocked IL-1beta in neutrophils in a NLRP3-dependent manner in mice and humans irrespective of age. 3-Hydroxybutyric Acid 67-70 interleukin 1 beta Rattus norvegicus 79-87 28082111-5 2017 In addition, dioscin suppressed the nuclear translocation of NF-kappaB and HMGB1, and subsequently decreased the mRNA levels of IL-1beta, IL-6, and TNF-alpha against inflammation. dioscin 13-20 interleukin 1 beta Rattus norvegicus 128-136 28087473-8 2017 Activation of microglia cells was reduced, and TLR4/NF-kappaB signals, which were markedly inhibited by SAFI treatment in ischemic hemisphere, were accompanied by reduced expression and release of cytokines IL-1beta and IL-6. safi 104-108 interleukin 1 beta Rattus norvegicus 207-215 28275350-10 2017 administration of CORM-2 lowers the CCI-elevated level of MMP-9 and pronociceptive interleukins (IL-1beta, IL-18, IL-6) in the dorsal L4-L6 spinal cord and/or DRG. CCI 36-39 interleukin 1 beta Rattus norvegicus 97-105 28243141-8 2017 Treatment with Bay11-7082, an inhibitor of the actions of IKK-beta, was able to inhibit expression and activation of the molecules (NLRP3, ASC, caspase-1, IL-1beta, IL-18, p-IkappaBalpha, and p-p65) and relieve the pain in rats. 3-(4-methylphenylsulfonyl)-2-propenenitrile 15-25 interleukin 1 beta Rattus norvegicus 155-163 29786261-14 2017 Conclusion: AdIL-10-BMSCs can inhibit secretion of TNF-alpha and IL-1beta from microglial cells and inhibit the nerve cell apoptosis around infarct brain tissue, which might contribute to its protective role upon cerebral ischemia reperfusion injury. adil-10-bmscs 12-25 interleukin 1 beta Rattus norvegicus 65-73 28195183-7 2017 In addition, we also found directional migration of IL-1beta-BMSCs was mediated by inceased C-X-C motif chemokine ligand (CXCL) 13 expression following SNL. c-x-c 92-97 interleukin 1 beta Rattus norvegicus 52-60 27883909-5 2017 RESULTS: In the high omega-3/low omega-6 group, a significant decrease was observed in masseter edema (p<0.0001), myeloperoxidase (p<0.0001), osteoclasts (p=0.0001) and TNF-alpha expression (p<0.0001), but not in IL-1beta expression. omega 21-26 interleukin 1 beta Rattus norvegicus 222-230 28187734-13 2017 RESULTS: SB treatment-reduced brain damage, as assessed by HE staining, suppressed the production of inflammatory markers-IL-1beta, chemokine CXCL10, and blocked ischemia-elicited upregulation of COX-2 in the damaged ipsilateral hemisphere. Butyric Acid 9-11 interleukin 1 beta Rattus norvegicus 122-130 30090495-10 2017 Nano NiO increased the concentrations of pro-inflammatory cytokines (IL-1beta and IL-6), but decreased the levels of anti-inflammatory cytokines (IL-4 and IL-10). nio 5-8 interleukin 1 beta Rattus norvegicus 69-77 28024294-11 2017 Serum AST, ALT, LDH, BUN, Cr and inflammatory cytokine (tumor necrosis factor-alpha, interleukin-1 beta and interleukin-6) levels were increased in CLP group that were prevented by celecoxib. Celecoxib 181-190 interleukin 1 beta Rattus norvegicus 85-103 27300038-6 2017 HSP also caused decrease in TNF-alpha, IL-1beta, IL-6, and CRP levels which was higher in the ZnONP-treated group. znonp 94-99 interleukin 1 beta Rattus norvegicus 39-47 27824430-11 2017 Conclusion: Long-term dietary fructose causes hepatic degeneration possibly via a decrease in eNOS, but increase in TNFalpha and IL-1beta, in both genders. Fructose 30-38 interleukin 1 beta Rattus norvegicus 129-137 27764704-0 2017 Buthionine sulfoximine, a glutathione depletor, attenuates endotoxic fever and reduces IL-1beta and IL-6 level in rats. Buthionine Sulfoximine 0-22 interleukin 1 beta Rattus norvegicus 87-95 27764704-1 2017 PURPOSE: The aim of our study was to investigate the effect of buthionine sulfoximine (BSO) - a glutathione depletor - on a course of endotoxic fever and IL-1beta and IL-6 production. Buthionine Sulfoximine 63-85 interleukin 1 beta Rattus norvegicus 154-162 27764704-1 2017 PURPOSE: The aim of our study was to investigate the effect of buthionine sulfoximine (BSO) - a glutathione depletor - on a course of endotoxic fever and IL-1beta and IL-6 production. Buthionine Sulfoximine 87-90 interleukin 1 beta Rattus norvegicus 154-162 27824430-10 2017 Resveratrol supplementation markedly attenuated hepatic degeneration, hyperemia and triglyceride content in association with reduced TNFalpha and IL-1beta levels, but enhanced IRbeta mRNA and IRS-1 protein, in male and female rats upon fructose feeding. Resveratrol 0-11 interleukin 1 beta Rattus norvegicus 146-154 27921246-13 2017 Se pretreatment caused a dose-dependent decrease in TNF-alpha, IL-1beta, sICAM-1, LDH, TP, AKP, and MDA when compared with the PM2.5-only exposure group. Selenium 0-2 interleukin 1 beta Rattus norvegicus 63-71 28237480-9 2017 CONCLUSIONS: Simvastatin can inhibit the expressions of NF-kappaB, TLR4 and IL-1beta proteins in rats with cerebral hemorrhage, and protect neurons and reduce secondary inflammatory damages by down-regulating the above protein-mediated inflammatory responses. Simvastatin 13-24 interleukin 1 beta Rattus norvegicus 76-84 27785530-8 2017 NLRP3 silencing blocked these effects in the rat model and HRMECs, confirming that inflammasome activation contributed to inflammation in DR. TXNIP expression was increased by reactive oxygen species (ROS) overproduction in animal and cell models, whereas antioxidant addition or TXNIP silencing blocked IL-1beta and IL-18 secretion in high glucose-exposed HRMECs, indicating that the ROS-TXNIP pathway mediates NLRP3 inflammasome activation. Reactive Oxygen Species 201-204 interleukin 1 beta Rattus norvegicus 304-312 27461472-10 2017 Phosphorylation of EphB1, activation of the astrocytes and microglial cells, and level of tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta in the spinal cord were significantly increased in rats with DNP. dnp 213-216 interleukin 1 beta Rattus norvegicus 129-151 28352356-6 2017 In addition, administration of PF (5, 10 and 20 mg/kg/day) for 28 days markedly exhibited an anti-arthritic activity by offsetting the body weight loss, inhibiting the paw edema, reducing the arthritis scores and the indices of thymus and spleen, inhibiting the expression levels of TNF-alpha, IL-1beta, IL-6, COX-2 and 5-LOX, and increasing the expression of IL-10, when compared with the respective control group in CFA-induced arthritis assay. 15,16-epoxy-8(9),13(16),14-labdatrien-7-ketone-19-oic acid glucopyranosyl ester 31-33 interleukin 1 beta Rattus norvegicus 294-302 27709316-0 2017 Coumestrol Counteracts Interleukin-1beta-Induced Catabolic Effects by Suppressing Inflammation in Primary Rat Chondrocytes. Coumestrol 0-10 interleukin 1 beta Rattus norvegicus 23-40 27709316-1 2017 In the present study, we investigated the anti-catabolic effects of coumestrol, a phytoestrogen derived from herbal plants, against interleukin-1beta-induced cartilage degeneration in primary rat chondrocytes and articular cartilage. Coumestrol 68-78 interleukin 1 beta Rattus norvegicus 132-149 27709316-3 2017 Although coumestrol did not significantly increase the proteoglycan contents in long-term culture, it abolished the interleukin-1beta-induced loss of proteoglycans in primary rat chondrocytes and knee articular cartilage. Coumestrol 9-19 interleukin 1 beta Rattus norvegicus 116-133 28040845-10 2017 Treatment with sodium valproate at the doses of 100 and 300 mg/Kg) decreased the MPO activity and colonic concentrations of IL-1beta, IL-6 and TNF-alpha. Valproic Acid 15-31 interleukin 1 beta Rattus norvegicus 124-132 27709316-4 2017 Furthermore, coumestrol suppressed the expression of matrix-degrading enzymes such as matrix metalloproteinase-13, -3, and -1 in primary rat chondrocytes stimulated with interleukin-1beta. Coumestrol 13-23 interleukin 1 beta Rattus norvegicus 170-187 27709316-5 2017 Moreover, the expression of catabolic factors such as nitric oxide synthase, cyclooxygenase-2, prostaglandin E2, and inflammatory cytokines in interleukin-1beta-stimulated primary rat chondrocytes was suppressed by coumestrol. Dinoprostone 95-111 interleukin 1 beta Rattus norvegicus 143-160 27709316-5 2017 Moreover, the expression of catabolic factors such as nitric oxide synthase, cyclooxygenase-2, prostaglandin E2, and inflammatory cytokines in interleukin-1beta-stimulated primary rat chondrocytes was suppressed by coumestrol. Coumestrol 215-225 interleukin 1 beta Rattus norvegicus 143-160 27709316-6 2017 In summary, these results indicate that coumestrol counteracts the catabolic effects induced by interleukin-1beta through the suppression of inflammation. Coumestrol 40-50 interleukin 1 beta Rattus norvegicus 96-113 26433940-4 2017 METHODS: We examined the effects of 9-week fructose-enriched diet applied immediately after weaning on nuclear factor kappaB (NF-kappaB) intracellular distribution, and on the expression of pro-inflammatory cytokines (IL-1beta and TNFalpha) and key antioxidative enzymes in the VAT of female rats. Fructose 43-51 interleukin 1 beta Rattus norvegicus 218-226 27895138-7 2017 Furthermore, we found that SB657510 reduced the expression of phosphorylated c-Jun N-terminal kinase (p-JNK) and nuclear factor-kappaB (NF-kappaB) p65 as well as subsequent secretion of interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha). SB 657510 27-35 interleukin 1 beta Rattus norvegicus 186-203 26433940-6 2017 RESULTS: Fructose-fed rats had increased VAT mass along with increased NF-kappaB nuclear accumulation and elevated IL-1beta, but not TNFalpha expression. Fructose 9-17 interleukin 1 beta Rattus norvegicus 115-123 27895138-7 2017 Furthermore, we found that SB657510 reduced the expression of phosphorylated c-Jun N-terminal kinase (p-JNK) and nuclear factor-kappaB (NF-kappaB) p65 as well as subsequent secretion of interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha). SB 657510 27-35 interleukin 1 beta Rattus norvegicus 205-213 27722988-13 2017 Ethanol increased plasma levels of TBARS, TNF-alpha, IL-6, IL-1beta, and IL-10, whereas it decreased NO x levels. Ethanol 0-7 interleukin 1 beta Rattus norvegicus 59-67 28005706-11 2017 Treatment of CKD + Ca/P/VitD rats with atrasentan reduced vascular calcification, SBP, PP and PWV, macrophage infiltration and expression of IL-1beta, IL-6, tumor necrosis factor, calgranulins and osteoblastic markers. Atrasentan 39-49 interleukin 1 beta Rattus norvegicus 141-149 26781077-8 2017 Preadministration of GYY4137 significantly attenuated acute lung injury induced by IAC, evidenced by reduced histologic scores and wet lung contents; improved blood gas parameters; reduced cell counts and protein amounts in bronchoalveolar lavage fluids; and reduced myeloperoxidase activity in lung tissues and plasma levels of tumor necrosis factor alpha, interleukin 6, and interleukin 1beta. GYY 4137 21-28 interleukin 1 beta Rattus norvegicus 377-394 28456769-0 2017 Neuroprotective effect of resveratrol against late cerebral ischemia reperfusion induced oxidative stress damage involves upregulation of osteopontin and inhibition of interleukin-1beta. Resveratrol 26-37 interleukin 1 beta Rattus norvegicus 168-185 28137413-0 2017 Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1beta-induced inflammation and apoptosis in vitro. Saponins 22-30 interleukin 1 beta Rattus norvegicus 74-91 27909743-9 2017 Stimulation of RASMCs with IL-1beta caused a marked increase in transplasmalemmal L-arginine uptake into RASMCs. rasmcs 15-21 interleukin 1 beta Rattus norvegicus 27-35 27585466-7 2017 Meanwhile, nimodipine was able to significantly reduce the expression of IL-1beta and TNF-alpha, but had no obvious effect on IL-10 or TGF-beta1. Nimodipine 11-21 interleukin 1 beta Rattus norvegicus 73-81 27909743-9 2017 Stimulation of RASMCs with IL-1beta caused a marked increase in transplasmalemmal L-arginine uptake into RASMCs. Arginine 82-92 interleukin 1 beta Rattus norvegicus 27-35 27909743-9 2017 Stimulation of RASMCs with IL-1beta caused a marked increase in transplasmalemmal L-arginine uptake into RASMCs. rasmcs 105-111 interleukin 1 beta Rattus norvegicus 27-35 27909743-10 2017 L-Arginine uptake in the presence of IL-1beta was markedly inhibited by R59949, while basal L-arginine uptake was not significantly affected by R59949. Arginine 0-10 interleukin 1 beta Rattus norvegicus 37-45 27909743-11 2017 Both IL-1beta-induced NO production and L-arginine uptake were abolished in the presence of cycloheximide (1 muM). Arginine 40-50 interleukin 1 beta Rattus norvegicus 5-13 27909743-11 2017 Both IL-1beta-induced NO production and L-arginine uptake were abolished in the presence of cycloheximide (1 muM). Cycloheximide 92-105 interleukin 1 beta Rattus norvegicus 5-13 28141871-9 2017 Two-way ANOVA showed an interaction of prenatal LP and postnatal HE on IL-6 and IL-1beta transcription. Helium 65-67 interleukin 1 beta Rattus norvegicus 80-88 27838288-11 2017 The expression of IL-1beta or TNF-alpha in the ankle synovial tissue was significantly decreased in the BoNT/A group compared to the NS group (p < 0.05). bont 104-108 interleukin 1 beta Rattus norvegicus 18-26 27771871-6 2017 Administration of either IPostC or CsA alone in nondiabetic animals significantly reduced CK, TNF-alpha, IL-1beta, and IL-6 concentrations, increased the p-GSK3beta and Bcl-2, and decreased the level of apoptosis (P < 0.05) but had no effect on diabetic hearts. Cyclosporine 35-38 interleukin 1 beta Rattus norvegicus 105-113 29762002-11 2017 Conclusion: Hydrogen-rich saline attenuated PWT and inhibited the release of cytokines TNF-alpha,IL-1beta,IL-6 in rats with PHN via activating autophagy. Hydrogen 12-20 interleukin 1 beta Rattus norvegicus 97-105 29762002-11 2017 Conclusion: Hydrogen-rich saline attenuated PWT and inhibited the release of cytokines TNF-alpha,IL-1beta,IL-6 in rats with PHN via activating autophagy. Sodium Chloride 26-32 interleukin 1 beta Rattus norvegicus 97-105 28009869-7 2017 BA significantly decreased the levels of serum insulin, IL-6, IL-1beta, TNF-alpha and blood glucose. betulinic acid 0-2 interleukin 1 beta Rattus norvegicus 62-70 28009869-8 2017 In addition, BA increased the activities of SOD, CAT and reduced the contents of MDA, IL-6, IL-1beta, and TNF-alpha in kidney tissues. betulinic acid 13-15 interleukin 1 beta Rattus norvegicus 92-100 28134775-9 2017 Additionally, PC led to significant increases in the levels of inflammatory markers including tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-33 (IL-33). Acetaminophen 14-16 interleukin 1 beta Rattus norvegicus 136-153 29979504-7 2017 Rhynchophylline relieved the experimental abdominal adhesion and decreased the levels of interleukin-1 beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the blood serum in a dose-dependent manner. rhyncophylline 0-15 interleukin 1 beta Rattus norvegicus 89-107 28134775-9 2017 Additionally, PC led to significant increases in the levels of inflammatory markers including tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-33 (IL-33). Acetaminophen 14-16 interleukin 1 beta Rattus norvegicus 155-163 29979504-7 2017 Rhynchophylline relieved the experimental abdominal adhesion and decreased the levels of interleukin-1 beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the blood serum in a dose-dependent manner. rhyncophylline 0-15 interleukin 1 beta Rattus norvegicus 109-117 28138318-9 2016 Paclitaxel increased the levels of phosphorylated protein kinase C, phosphorylated nuclear factor kappaB, phosphodiesterase 4D (PDE4D), IL-1beta, and monocyte chemoattractant protein-1 in the lumbar dorsal root ganglia; however, tempol decreased these levels. Paclitaxel 0-10 interleukin 1 beta Rattus norvegicus 136-144 28086859-9 2017 RESULTS: In an in vitro study, CBTE inhibited the production of NO and PGE2 and also decreased the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) activity, interleukin (IL)-1beta, IL-6 and tumuor necrosis factor-alpha. cbte 31-35 interleukin 1 beta Rattus norvegicus 188-210 28088201-12 2017 Immunohistochemical analysis showed the activation of astrocytes and microglia and the increase of the IL-1beta and TNF-alpha levels in the spinal cord after an oxaliplatin injection. Oxaliplatin 161-172 interleukin 1 beta Rattus norvegicus 103-111 28074914-8 2017 Treatment with HSYA also alleviated strike-induced increases in TNF-alpha, IL-1beta, IL-6, VCAM-1, and ICAM-1mRNA levels and inhibited the increased activation of NF-kappaB and phosphorylation of p38 MAPK in muscle tissue. hydroxysafflor yellow A 15-19 interleukin 1 beta Rattus norvegicus 75-83 28372289-7 2017 Furthermore, sitagliptin significantly decreased the levels of the inflammatory cytokines IL-1beta, TNF-alpha, and IL-6 but not IL-10. Sitagliptin Phosphate 13-24 interleukin 1 beta Rattus norvegicus 90-98 28056930-8 2017 Additionally, oral treatment with AERCAP significantly decreased the macroscopic damage area, improved the microscopic structure, and reduced the malondialdehyde (MDA) content, IL-1beta and TNF-alpha levels in colonic tissue compared with the TNBS control group in rats. aercap 34-40 interleukin 1 beta Rattus norvegicus 177-185 27569183-3 2017 In this study we looked at how Fluvoxamine treatment regulates depressive-like signs, motor impairments and the expression of IL-1beta, IL-6, TNF-alpha, TGF-beta and IL-10 cytokines in the striatum of a stressed Parkinsonian rat model. Fluvoxamine 31-42 interleukin 1 beta Rattus norvegicus 126-134 27815021-2 2017 Since it was reported that a highly selective cyclooxygenase-2 (COX-2) inhibitor, NS398, completely inhibited IL-1beta-induced sleep in rats, IL-1beta-induced sleep had been believed to be mediated by prostanoids, most probably PGD2. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 82-87 interleukin 1 beta Rattus norvegicus 110-118 27815021-2 2017 Since it was reported that a highly selective cyclooxygenase-2 (COX-2) inhibitor, NS398, completely inhibited IL-1beta-induced sleep in rats, IL-1beta-induced sleep had been believed to be mediated by prostanoids, most probably PGD2. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 82-87 interleukin 1 beta Rattus norvegicus 142-150 27815021-2 2017 Since it was reported that a highly selective cyclooxygenase-2 (COX-2) inhibitor, NS398, completely inhibited IL-1beta-induced sleep in rats, IL-1beta-induced sleep had been believed to be mediated by prostanoids, most probably PGD2. Prostaglandins 201-212 interleukin 1 beta Rattus norvegicus 142-150 27815021-2 2017 Since it was reported that a highly selective cyclooxygenase-2 (COX-2) inhibitor, NS398, completely inhibited IL-1beta-induced sleep in rats, IL-1beta-induced sleep had been believed to be mediated by prostanoids, most probably PGD2. Prostaglandin D2 228-232 interleukin 1 beta Rattus norvegicus 142-150 27815021-5 2017 These results indicate that IL-1beta-induced NREM sleep is independent of the PGD2/DP1R system and other COX-2-derived prostaglandins in rats and mice. Prostaglandins 119-133 interleukin 1 beta Rattus norvegicus 28-36 27239677-6 2017 AgNP administration decreased Glutathione (GSH) levels and activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and increased levels of malondialdehyde (MDA) and expression of interleukin-1 beta (IL-1beta), IL-6, and tumor necrosis factor alpha (TNF-alpha). agnp 0-4 interleukin 1 beta Rattus norvegicus 214-232 27239677-6 2017 AgNP administration decreased Glutathione (GSH) levels and activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and increased levels of malondialdehyde (MDA) and expression of interleukin-1 beta (IL-1beta), IL-6, and tumor necrosis factor alpha (TNF-alpha). agnp 0-4 interleukin 1 beta Rattus norvegicus 234-242 28123710-8 2017 In addition, the administration of propofol increased the serum NO concentration, and reduced ET-1 and cTnT levels, as well as levels of inflammatory mediators including IL-1beta, IL-6 and TNF-alpha. Propofol 35-43 interleukin 1 beta Rattus norvegicus 170-178 29359143-6 2017 Results: DEX protected against H/R-induced cell damage and inflammation, as evidenced by increased cell survival rates, decreased LDH activity, and decreased TNF-alpha, IL-6, and IL-1beta mRNA levels, as well as TLR4 and NF-kappaB protein expression. Dexmedetomidine 9-12 interleukin 1 beta Rattus norvegicus 179-187 29359143-6 2017 Results: DEX protected against H/R-induced cell damage and inflammation, as evidenced by increased cell survival rates, decreased LDH activity, and decreased TNF-alpha, IL-6, and IL-1beta mRNA levels, as well as TLR4 and NF-kappaB protein expression. r 0-1 interleukin 1 beta Rattus norvegicus 179-187 28516791-9 2017 For IL-1beta and IL-6 levels a statistically significant decline was observed in the LPS+thalidomide and LPS+etanercept treated groups compared to the LPS group (p < 0.05). Thalidomide 89-100 interleukin 1 beta Rattus norvegicus 4-12 27569183-9 2017 Lipid peroxidation, mRNA levels of IL-1beta, IL-6 and TNF-alpha were down-regulated while IL-10 and TGF-beta levels were up-regulated in the lesioned striatum of Fluvoxamine treated rats. Fluvoxamine 162-173 interleukin 1 beta Rattus norvegicus 35-43 28471231-6 2017 RESULTS: Mtx administration increased histopathological damage, TNF-alpha, IL-1beta, TOS, TAS and OSI levels in tissues; AST, ALT levels in the blood. Methotrexate 9-12 interleukin 1 beta Rattus norvegicus 75-83 28471231-7 2017 Sinusoidal dilatation, inflammatory cell infiltration and congestion were significantly improved in the Mtx-L aon histopathologic examination of the rats.In Mtx-L group that were treated at the Lyc, TNF-alpha and IL-1beta levels of liver tissue were decreased significantly compared to Mtx group whereas the decrease in OSI was not significant. Methotrexate 104-107 interleukin 1 beta Rattus norvegicus 213-221 28528333-8 2017 Compared with the blank group, the 1,25-(OH)2D3 and miR-22 inhibitors groups exhibited higher proliferation inhibition and apoptosis rates, lower levels of pro-inflammatory cytokines (IL-1beta, IL-6, IL-8, and PGE2), and decreased mRNA expressions of MMP-3, INOS, and Cox-2. Calcitriol 35-47 interleukin 1 beta Rattus norvegicus 184-192 26883519-10 2017 The results showed that perampanel suppressed the expression of pro-inflammatory cytokines TNF-alpha and IL-1beta, whereas increased the levels of anti-inflammatory cytokines IL-10 and TGF-beta1. perampanel 24-34 interleukin 1 beta Rattus norvegicus 105-113 29181410-6 2017 RT-PCR results indicated that the mRNA expressions of TNF-alpha, IL-6, and IL-1beta were downregulated by toonaciliatin K. Toonaciliatin K 106-121 interleukin 1 beta Rattus norvegicus 75-83 29181410-7 2017 The toonaciliatin K inhibited TNF-alpha, IL-6, and IL-1beta levels stimulated by LPS. Toonaciliatin K 4-19 interleukin 1 beta Rattus norvegicus 51-59 29236548-10 2017 Furthermore, treatment with budesonide significantly decreased the levels of MDA, MPO, and XO in the lung and the levels of TNF-alpha, IL-1beta, IL-6, and neutrophil elastase, but increased IL-10 in the BALF, accompanied by significantly reduced levels of serum P-selectin and LFA-1 in rats. Budesonide 28-38 interleukin 1 beta Rattus norvegicus 135-143 28693025-8 2017 Meanwhile, high salt-induced increases in the mRNA level of proinflammatory factors interleukin-1beta and interleukin-6 were blocked in VA-treated rats. Salts 16-20 interleukin 1 beta Rattus norvegicus 84-101 28693025-8 2017 Meanwhile, high salt-induced increases in the mRNA level of proinflammatory factors interleukin-1beta and interleukin-6 were blocked in VA-treated rats. Valproic Acid 136-138 interleukin 1 beta Rattus norvegicus 84-101 29111854-6 2017 We observed differential methylation of Bdnf and Il6 in the pons, Nr3c1 in the cerebellum, and Il1b in the hippocampus in response to acute morphine exposure (all P value < 0.05). Morphine 140-148 interleukin 1 beta Rattus norvegicus 95-99 27776252-1 2017 Although we have recently demonstrated that carrageenan-induced inflammation upregulates the expression of spinal interleukin (IL)-1beta, which inhibits spinal astrocyte activation and results in the delayed development of Mirror-Image Pain (MIP), little is known regarding the mechanisms that underlie how spinal IL-1beta inhibits the astrocyte activation. Carrageenan 44-55 interleukin 1 beta Rattus norvegicus 314-322 29104606-6 2017 Accordingly, astilbin exhibited remarkable inhibitory effects on TNF-alpha, IL-1beta, and IL-6 mRNA expression. astilbin 13-21 interleukin 1 beta Rattus norvegicus 76-84 29104606-7 2017 Significant decrease of serum cytokine levels of TNF-alpha, IL-1beta, and IL-6 was also observed in astilbin-treated AA rats compared to the vehicle-treated AA rats. astilbin 100-108 interleukin 1 beta Rattus norvegicus 60-68 28854431-9 2017 RESULTS: Iopromide caused elevation of SCr, BUN and NGAL level, decrease of endogenous creatinine clearance, morphological injury and tubular apoptosis, enhanced IL-1beta and IL-18 expression, and increased expression of S100A8/A9, TLR4 and NLRP3 inflammsome. iopromide 9-18 interleukin 1 beta Rattus norvegicus 162-170 29234386-5 2017 It was found that OGD/R significantly decreased the cell viability and lactate dehydrogenase (LDH) activity and increased the release of IL-1beta, IL-6, and TNF-alpha in PC12 cells, and these effects were suppressed by XJDH and one of its major active constituents, paeoniflorin. peoniflorin 266-278 interleukin 1 beta Rattus norvegicus 137-145 29599803-7 2017 beta-Asarone improved cognitive impairment, alleviated Abeta deposition and hippocampal damage, and inhibited GFAP, AQP4, IL-1beta, and TNF-alpha expression. asarone 0-12 interleukin 1 beta Rattus norvegicus 122-130 29599803-8 2017 These results suggested that beta-asarone could alleviate the symptoms of AD by protecting astrocytes, possibly by inhibiting TNF-alpha and IL-1beta secretion and then downregulating AQP4 expression. asarone 29-41 interleukin 1 beta Rattus norvegicus 140-148 27709321-2 2017 Lignans were purified from guaiac resin (also known as gum guaiacum) by monitoring the nitric oxide (NO) production in rat hepatocytes treated with an inflammatory cytokine interleukin-1beta (IL-1beta). Lignans 0-7 interleukin 1 beta Rattus norvegicus 173-190 27709321-2 2017 Lignans were purified from guaiac resin (also known as gum guaiacum) by monitoring the nitric oxide (NO) production in rat hepatocytes treated with an inflammatory cytokine interleukin-1beta (IL-1beta). Lignans 0-7 interleukin 1 beta Rattus norvegicus 192-200 28066135-5 2017 The results indicated that atractylodin reduced proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6 in the plasma and inhibited the expression of inflammatory mediators iNOS and NF-kappa B in jejunal segments in both CP and DP rats. atractylodin 27-39 interleukin 1 beta Rattus norvegicus 85-93 27406329-8 2017 GA also lowered the apoptotic rate and the levels of LDH, CK-MB and IL-1beta in a dose-dependent manner. Glycyrrhetinic Acid 0-2 interleukin 1 beta Rattus norvegicus 68-76 28066137-0 2017 Betulin suppressed interleukin-1beta-induced gene expression, secretion and proteolytic activity of matrix metalloproteinase in cultured articular chondrocytes and production of matrix metalloproteinase in the knee joint of rat. betulin 0-7 interleukin 1 beta Rattus norvegicus 19-36 28066137-3 2017 Effect of betulin on IL-1beta-induced secretion and proteolytic activity of MMP-3 was investigated using western blot analysis and casein zymography, respectively. betulin 10-17 interleukin 1 beta Rattus norvegicus 21-29 28845732-10 2017 The observed hyperbaric oxygen-induced reductions in glial cell activation and neuroinflammation, as indicated by the production of TNF-alpha, IL-1beta, and fractalkine, were also prominently diminished in the group with kindlin-1 overexpression. Oxygen 24-30 interleukin 1 beta Rattus norvegicus 143-151 28066142-6 2017 Intracisternal injection of bumetanide, an Na-K-Cl cotransporter (NKCC 1) inhibitor, reversed the IL-1beta-induced mechanical allodynia. Bumetanide 28-38 interleukin 1 beta Rattus norvegicus 98-106 28066142-8 2017 However, in some neurons, application of GABA or muscimol led to membrane depolarization in the IL-1beta-treated rats. gamma-Aminobutyric Acid 41-45 interleukin 1 beta Rattus norvegicus 96-104 28066142-8 2017 However, in some neurons, application of GABA or muscimol led to membrane depolarization in the IL-1beta-treated rats. Muscimol 49-57 interleukin 1 beta Rattus norvegicus 96-104 28637984-6 2017 Although rosuvastatin reduced the levels of IL-1beta, they did not differ significantly between the PR and P groups. Rosuvastatin Calcium 9-21 interleukin 1 beta Rattus norvegicus 44-52 28714351-3 2017 Growing evidences have supported that peripheral interleukin-1beta is critical in enhancing paclitaxel-induced neuropathic pain. Paclitaxel 92-102 interleukin 1 beta Rattus norvegicus 49-66 28714351-6 2017 Paclitaxel resulted in expression of NLRP3 and activated fragments of caspase-1 and interleukin-1beta in L4-6 dorsal root ganglia and sciatic nerve three weeks after injection, indicating activation of NLRP3 inflammasome. Paclitaxel 0-10 interleukin 1 beta Rattus norvegicus 84-101 28614825-11 2017 Ceftiofur 20 mg/kg/day significantly alleviated hyperalgesia, but not allodynia, and the increased iNOS and IL-1beta expression was attenuated in neuropathic rats at both doses while decreasing p38 MAPK expression only at 20 mg/kg/day. ceftiofur 0-9 interleukin 1 beta Rattus norvegicus 108-116 28614825-13 2017 CONCLUSIONS: Ceftiofur has anti-inflammatory effects by decreasing iNOS, IL-1beta, and p38 MAPK expression in lumbar spinal cord, and treatment of neuropathic rats with repeated doses of ceftiofur for 14 days results in antihyperalgesic effects. ceftiofur 13-22 interleukin 1 beta Rattus norvegicus 73-81 28614825-13 2017 CONCLUSIONS: Ceftiofur has anti-inflammatory effects by decreasing iNOS, IL-1beta, and p38 MAPK expression in lumbar spinal cord, and treatment of neuropathic rats with repeated doses of ceftiofur for 14 days results in antihyperalgesic effects. ceftiofur 187-196 interleukin 1 beta Rattus norvegicus 73-81 28793299-10 2017 Whereas adenosine pretreatment decreased brain TNF-alpha, IL-1beta, and IL-6 levels significantly (p < 0.05), caffeine pretreatment reduced brain cytokine levels slightly but nonsignificantly (p > 0.05). Adenosine 8-17 interleukin 1 beta Rattus norvegicus 58-66 28123623-8 2017 Moreover, interleukin (IL)-1beta, IL-6 and TNF-alpha mRNA levels were significantly higher in the paraquat group (P<0.01, respectively). Paraquat 98-106 interleukin 1 beta Rattus norvegicus 10-32 28713490-10 2017 The results showed that picroside II treatment reduced the level of ALT, AST, NF-kappaB, IL-1beta, IL-6, TNF-alpha, and SIRT1 (NAD+-dependent deacetylase) and increased the level of SOD and GSH. picroside II 24-36 interleukin 1 beta Rattus norvegicus 89-97 28467992-4 2017 Furthermore, the effect of rutin on the tumor necrosis factor-alpha and interleukin-1beta in arthritic rats showed does-dependent lowering of these cytokines with maximum benefit at 15 mg/kg dose and the level of both NF-kappaB p65 and NF-kappaBp65 (Ser536) has been significantly reduced in the presence of rutin. Rutin 27-32 interleukin 1 beta Rattus norvegicus 72-89 28467992-4 2017 Furthermore, the effect of rutin on the tumor necrosis factor-alpha and interleukin-1beta in arthritic rats showed does-dependent lowering of these cytokines with maximum benefit at 15 mg/kg dose and the level of both NF-kappaB p65 and NF-kappaBp65 (Ser536) has been significantly reduced in the presence of rutin. Rutin 308-313 interleukin 1 beta Rattus norvegicus 72-89 28096675-8 2017 ZPP group compared to ICH: HO-1 positive rate and mRNA expression were decreased, neurological deficit score and cell apoptosis rate were decreased, Caspase 3, Caspase 8, Caspase 9 activity were decreased, level of TNF-alpha, IL-1beta, IL-6 and IL-8 were decreased, Bcl-2 expression was upregulated, Bax, p-NF-kappaB p65 and p-IkappaBalpha expression were downregulated, and the differences were statistically significant (P<0.01). zinc protoporphyrin 0-3 interleukin 1 beta Rattus norvegicus 226-234 27742410-10 2016 Furthermore, MPP+-induced elevations in alpha-synuclein aggregates (a pathological hallmark of PD), ED-1 (a biomarker of activated microglia), activated caspase-1 (a proinflammatory caspase), IL-1beta and cathepsin B (a cysteine lysosomal protease) in the infused SN were attenuated in the baicalein-treated rats. mangion-purified polysaccharide (Candida albicans) 13-17 interleukin 1 beta Rattus norvegicus 192-200 28030563-3 2016 Mild TBI caused a rapid (within 6 h post-mTBI) upregulation of synthesis of TNF-alpha and IL-1beta in the cerebral cortex and hippocampus, followed by an increase in production of neutrophil (CXCL1-3) and monocyte (CCL2) chemoattractants. Thioacetazone 5-8 interleukin 1 beta Rattus norvegicus 90-98 27930719-7 2016 In addition, eBV suppressed compound 48/80-induced expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in RBL-2H3 cells. (2S)-2-amino-1-[(3aR,6aS)-5-[(5-chloro-1H-indol-3-yl)methyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-3-(1H-indol-3-yl)propan-1-one 13-16 interleukin 1 beta Rattus norvegicus 109-126 28078028-7 2016 Ro25-6981 and amitriptyline treatment also decreased colorectal expression of TNF-alpha and IL-1beta induced by IBS model. Amitriptyline 14-27 interleukin 1 beta Rattus norvegicus 92-100 27955671-10 2016 PIC administration also led to an increase in interleukin 1beta (IL-1beta) levels in the hippocampus in P14 and P75 rats. Poly I-C 0-3 interleukin 1 beta Rattus norvegicus 46-63 27955671-10 2016 PIC administration also led to an increase in interleukin 1beta (IL-1beta) levels in the hippocampus in P14 and P75 rats. Poly I-C 0-3 interleukin 1 beta Rattus norvegicus 65-73 27930719-7 2016 In addition, eBV suppressed compound 48/80-induced expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in RBL-2H3 cells. (2S)-2-amino-1-[(3aR,6aS)-5-[(5-chloro-1H-indol-3-yl)methyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-3-(1H-indol-3-yl)propan-1-one 13-16 interleukin 1 beta Rattus norvegicus 128-136 27666336-5 2016 After the administration of indomethacin to rats, ulcers were observed in the small intestine and expression of CYP3A1, the major isoform of hepatic CYP, was significantly down-regulated in the liver, accompanied by increased expression of inducible nitric oxide synthase, tumor necrosis factor alpha, interleukin (IL)-1beta and IL-6, in the small intestine and the liver. Indomethacin 28-40 interleukin 1 beta Rattus norvegicus 302-324 27558948-10 2016 CONCLUSIONS: Our data demonstrated that the protective effects of triptolide against DCM might attribute to inhibition of TLR4-induced NF-kappaB/IL-1beta immune pathway, suppression of NF-kappaB/TNF-alpha/VCAM-1 inflammatory pathway and down-regulation of TGF-beta1/alpha-SMA/Vimentin fibrosis pathway. triptolide 66-76 interleukin 1 beta Rattus norvegicus 145-153 27560658-7 2016 After 28 d of injection, administration of only PBS into the site of muscle injury caused up-regulation in the levels of interleukins IL-1beta, IL-6, tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta1), interferon alpha (IFN-alpha) and down-regulate the level of IL-10 in muscular tissue comparing to the untreated control. pbs 48-51 interleukin 1 beta Rattus norvegicus 134-142 28076507-7 2016 RESULTS:: Clinical scores, TNF-alpha, IL-1beta, liver/kidney proof levels, and lung injury were significantly reduced in coconut water+NaCl 3%+simvastatin group treated rats, comparing with the other resuscitation treatments. Sodium Chloride 135-139 interleukin 1 beta Rattus norvegicus 38-46 28076507-7 2016 RESULTS:: Clinical scores, TNF-alpha, IL-1beta, liver/kidney proof levels, and lung injury were significantly reduced in coconut water+NaCl 3%+simvastatin group treated rats, comparing with the other resuscitation treatments. Simvastatin 143-154 interleukin 1 beta Rattus norvegicus 38-46 26332274-7 2016 In addition to stimulation of oxidative DNA damage, acrylonitrile triggered induction of pro-inflammatory cytokines Tnfalpha, Il-1beta, and Ccl2, and the growth stimulatory cyclin D1 and cyclin D2 genes, which were effectively down-regulated with antioxidant treatment. Acrylonitrile 52-65 interleukin 1 beta Rattus norvegicus 126-134 28076507-7 2016 RESULTS:: Clinical scores, TNF-alpha, IL-1beta, liver/kidney proof levels, and lung injury were significantly reduced in coconut water+NaCl 3%+simvastatin group treated rats, comparing with the other resuscitation treatments. Water 129-134 interleukin 1 beta Rattus norvegicus 38-46 27757590-10 2016 Niflumic acid restored core and associated symptoms of peripheral neuropathy by suppressing oxidative-nitrosative stress, inflammatory cytokines (TNF-alpha, IL-1beta) and TRPV1 level in stavudine-induced neuropathic pain in rats. Niflumic Acid 0-13 interleukin 1 beta Rattus norvegicus 157-165 27560658-8 2016 Bone marrow MSCs + PBS injected at the site of muscle injury significantly down-regulate the inflammatory cytokines levels IL-1beta and IL-6 and TNF-alpha, TGF-beta1 and IFN-alpha and up-regulate the level of IL-10. pbs 19-22 interleukin 1 beta Rattus norvegicus 123-131 26671617-6 2016 DBT rats exhibited a significant increase in HIP levels of TNFalpha, IL-1beta, and IL-6 and a decrease in HIP 5-HT and NA levels. dbt 0-3 interleukin 1 beta Rattus norvegicus 69-77 27377707-0 2016 KYNA analogue SZR72 modifies CFA-induced dural inflammation- regarding expression of pERK1/2 and IL-1beta in the rat trigeminal ganglion. 3-chloro-4-fluoroaniline 29-32 interleukin 1 beta Rattus norvegicus 97-105 27905989-10 2016 NaB also reduced expression of the inflammatory cytokine IL-1beta in circulation and IL-18 in the ischemic hemisphere. nab 0-3 interleukin 1 beta Rattus norvegicus 57-65 27905989-11 2016 At the late acute phase (5 days post stroke), NaB treatment further suppressed MCAo-induced increase of IL-1beta, IL-17A, and IL-18 in brain lysates (cortex and striatum) from the ischemic hemisphere, and decreased ischemia-induced upregulation of IL-1beta and IL-18 in circulation, indicating a potent anti-inflammatory effect of the HDAC inhibitor. nab 46-49 interleukin 1 beta Rattus norvegicus 104-112 27905989-11 2016 At the late acute phase (5 days post stroke), NaB treatment further suppressed MCAo-induced increase of IL-1beta, IL-17A, and IL-18 in brain lysates (cortex and striatum) from the ischemic hemisphere, and decreased ischemia-induced upregulation of IL-1beta and IL-18 in circulation, indicating a potent anti-inflammatory effect of the HDAC inhibitor. nab 46-49 interleukin 1 beta Rattus norvegicus 248-256 27748894-10 2016 Our results also revealed that helenalin, an NF-kappaB pathway inhibitor, decreased the expression of P2X7R, IL-1beta, IL-6, TNF-alpha, SP, PGE2 and MMP-13, which was induced by MIA, in the knee cartilage tissues of rats with OA. helenalin 31-40 interleukin 1 beta Rattus norvegicus 109-117 27771081-3 2016 Pretreatment with goat whey (1, 2, and 4g/kg) and sulfasalazine (250mg/kg) on colitic rats improved colonic inflammatory markers, including myeloperoxidase activity, leukotriene B4 levels, as well as the production of proinflammatory cytokines IL-1beta and tumor necrosis factor-alpha. Sulfasalazine 50-63 interleukin 1 beta Rattus norvegicus 244-284 27825050-12 2016 Combined treatment of rats (FRH+PBP) results in decrease of IL-1beta, IL-6 and TNF-alpha mRNA expression in peripheral blood mononuclear cells compared to cells derived from rats treated with protein-bound polysaccharides extract alone. frh 28-31 interleukin 1 beta Rattus norvegicus 60-68 27654903-6 2016 IL-1beta positively correlated with glucose AUC response. Glucose 36-43 interleukin 1 beta Rattus norvegicus 0-8 28058139-1 2016 OBJECTIVE: Paclitaxel is used in the treatment of cancer, and it may cause interleukin-1 beta (IL-1beta)-related peripheral neuropathic pain. Paclitaxel 11-21 interleukin 1 beta Rattus norvegicus 75-93 27249953-11 2016 The tricaffeoylquinic acid (3) showed a significantly higher activity than the other three dicaffeoylquinic acids (1, 2, 4) and indomethacin in reduction of TNF-alpha and IL-1beta concentrations (8.44 +- 0.62 and 5.83 +- 0.57 pg/mL compared to 12.60 +- 1.30 and 52.91 +- 5.20 pg/mL induced by indomethacin, respectively). tricaffeoylquinic acid 4-26 interleukin 1 beta Rattus norvegicus 171-179 27249953-11 2016 The tricaffeoylquinic acid (3) showed a significantly higher activity than the other three dicaffeoylquinic acids (1, 2, 4) and indomethacin in reduction of TNF-alpha and IL-1beta concentrations (8.44 +- 0.62 and 5.83 +- 0.57 pg/mL compared to 12.60 +- 1.30 and 52.91 +- 5.20 pg/mL induced by indomethacin, respectively). caffeoylquinic acid 91-113 interleukin 1 beta Rattus norvegicus 171-179 27249953-11 2016 The tricaffeoylquinic acid (3) showed a significantly higher activity than the other three dicaffeoylquinic acids (1, 2, 4) and indomethacin in reduction of TNF-alpha and IL-1beta concentrations (8.44 +- 0.62 and 5.83 +- 0.57 pg/mL compared to 12.60 +- 1.30 and 52.91 +- 5.20 pg/mL induced by indomethacin, respectively). Indomethacin 128-140 interleukin 1 beta Rattus norvegicus 171-179 27649096-7 2016 CS markedly decreased the expression of nNOS, iNOS and IL-1beta in HIP. Cesium 0-2 interleukin 1 beta Rattus norvegicus 55-63 27825819-19 2016 NaHS raised mRNA or protein expression for CSE, COX-1 and decreased mRNA expression for IL-1beta and COHb level in blood. sodium bisulfide 0-4 interleukin 1 beta Rattus norvegicus 88-96 27793418-0 2016 Omega-3 fatty acids decreases oxidative stress, tumor necrosis factor-alpha, and interleukin-1 beta in hyperthyroidism-induced hepatic dysfunction rat model. Fatty Acids, Omega-3 0-19 interleukin 1 beta Rattus norvegicus 81-99 27793418-5 2016 Hyperthyroid omega-3 treated group showed significantly increased final body weight and body weight gain, decreased liver weight to body weight ratio, decreased serum triiodo-l-thyronine level, increased serum thyroid stimulating hormone level, decreased serum levels of alanine transaminase, aspartate transaminase and tumor necrosis factor-alpha, increased hepatic levels of total antioxidant capacity and decreased hepatic levels of total peroxide and interleukin-1 beta when compared with the hyperthyroid group. Fatty Acids, Omega-3 13-20 interleukin 1 beta Rattus norvegicus 455-473 27825819-15 2016 ASA caused hemorrhagic gastric mucosal damage and significantly decreased GBF, H2S production, CO content, mRNA or protein expression for CSE, 3-MST, HO-2 and increased mRNA and/or protein expression for CBS, HO-1, Nrf-2, HIF-1alpha, iNOS, IL-1beta, COX-2 in gastric mucosa and COHb concentration in blood. Aspirin 0-3 interleukin 1 beta Rattus norvegicus 240-248 27994500-11 2016 The inflammatory cytokines" mRNA levels of tumor necrosis factor alpha, interleukin 6, and interleukin 1beta were all suppressed by resveratrol treatment. Resveratrol 132-143 interleukin 1 beta Rattus norvegicus 91-108 28058139-1 2016 OBJECTIVE: Paclitaxel is used in the treatment of cancer, and it may cause interleukin-1 beta (IL-1beta)-related peripheral neuropathic pain. Paclitaxel 11-21 interleukin 1 beta Rattus norvegicus 95-103 27904712-0 2016 Hyperbaric oxygen protects mandibular condylar chondrocytes from interleukin-1beta-induced apoptosis via the PI3K/AKT signaling pathway. Oxygen 11-17 interleukin 1 beta Rattus norvegicus 65-82 27619001-7 2016 Western blotting results suggested that CCI induces the upregulation of the pronociceptive proteins IL-18, IL-6 and IL-1beta in the ipsilateral lumbar spinal cord and DRG, but no changes in the levels of the antinociceptive proteins IL-18BP, IL-1RA and IL-10 were observed. CCI 40-43 interleukin 1 beta Rattus norvegicus 116-124 27568839-9 2016 Zingerone pretreatment significantly (P<0.05) decreased serum cTnI, Hs CRP, lysosomal hydrolases and heart lysosomal LPO and down regulated myocardial TNF-alpha, IL-1beta and IL-6 genes and prevented coronary thrombosis in isoproterenol induced myocardial infarcted rats. zingerone 0-9 interleukin 1 beta Rattus norvegicus 165-173 27852964-11 2016 Furthermore, we found that spinal IL-1beta was dramatically increased in cyclophosphamide-induced cystitis, and activated astrocytes were the only source of IL-1beta release, which contributed to allodynia in cystitis rats. Cyclophosphamide 73-89 interleukin 1 beta Rattus norvegicus 34-42 27619001-8 2016 Interestingly, BoNT/A injection suppressed the CCI-induced upregulation of IL-18 and IL-1beta in the spinal cord and/or DRG and increased the levels of IL-10 and IL-1RA in the DRG. bont 15-19 interleukin 1 beta Rattus norvegicus 85-93 27619001-8 2016 Interestingly, BoNT/A injection suppressed the CCI-induced upregulation of IL-18 and IL-1beta in the spinal cord and/or DRG and increased the levels of IL-10 and IL-1RA in the DRG. CCI 47-50 interleukin 1 beta Rattus norvegicus 85-93 27519154-7 2016 Exploration of changes induced by early post-trauma morphine revealed that this elevated gene expression of TLR4, TNF, IL-1beta, and NLRP3, as well as IL-1beta protein at the site of spinal cord injury. Morphine 52-60 interleukin 1 beta Rattus norvegicus 119-127 27452660-9 2016 RESULTS: ETCB was able to inhibit IL-1beta and nitrite production in vitro in RAW 264.7 macrophages. etcb 9-13 interleukin 1 beta Rattus norvegicus 34-42 27565759-11 2016 The levels of serum CRP, TNF-alpha, IL-1beta, and IL-6 in EAP group were all significantly higher than these in control group. phosphorylethanolamine 58-61 interleukin 1 beta Rattus norvegicus 36-44 27519154-7 2016 Exploration of changes induced by early post-trauma morphine revealed that this elevated gene expression of TLR4, TNF, IL-1beta, and NLRP3, as well as IL-1beta protein at the site of spinal cord injury. Morphine 52-60 interleukin 1 beta Rattus norvegicus 151-159 27541924-8 2016 NaHS and CORM-2 inhibited gastric expression of HIF-1alpha protein and HO-1, HIF-1alpha, NF-kappaB, COX-2, iNOS, IL-1beta, TNF-alpha mRNAs but failed to affect those of HO-2, GPx-1, and SOD-2. sodium bisulfide 0-4 interleukin 1 beta Rattus norvegicus 113-121 27569904-4 2016 In L6-GLUT4myc cells, stimulation with IL-1beta for 24 h promoted GLUT4 translocation to the plasma membrane and increased glucose uptake in a concentration-dependent manner, whereas short-term stimulation with IL-1 for up to 6 h did not affect that. Glucose 123-130 interleukin 1 beta Rattus norvegicus 39-47 27541924-9 2016 CONCLUSION: Both H2S and CO released from their donors, NaHS and CORM-2, protect gastric mucosa compromised by stress against alendronate-induced gastric damage via mechanism involving downregulation of HIF-1alpha, NF-kappaB and proinflammatory factors COX-2, iNOS, IL-1beta, and TNF-alpha. Hydrogen Sulfide 17-20 interleukin 1 beta Rattus norvegicus 266-274 27694039-5 2016 KOS administration improved rat weight, colonic length, damage score, structure of gut microbiota, production of SCFA, and reduced colon tissue levels of malondialdehyde (MDA), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta). KOS 0-3 interleukin 1 beta Rattus norvegicus 288-305 27721162-4 2016 The aim of the present study was to investigate whether topiramate, a new generation antiepileptic drug with a complex mechanism of action, could affect the lipopolysaccharide (LPS)-induced release of TNF-alpha, IL-1beta and IL-6 from primary rat microglial cell cultures. Topiramate 56-66 interleukin 1 beta Rattus norvegicus 212-220 27721162-7 2016 Topiramate (1, 10, 100mug/ml; 24h incubation) produced a statistically significant decrease in LPS-stimulated IL-1beta and IL-6 levels from primary rat microglial cells in a concentration-dependent manner. Topiramate 0-10 interleukin 1 beta Rattus norvegicus 110-118 27694039-5 2016 KOS administration improved rat weight, colonic length, damage score, structure of gut microbiota, production of SCFA, and reduced colon tissue levels of malondialdehyde (MDA), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta). KOS 0-3 interleukin 1 beta Rattus norvegicus 307-315 27725274-9 2016 Further studies indicated that treatment with mefunidone mitigated the expressions of tumor necrosis factoralpha (TNFalpha) and interleukin-1beta (IL-1beta) in the kidney. 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one 46-56 interleukin 1 beta Rattus norvegicus 128-145 27725274-9 2016 Further studies indicated that treatment with mefunidone mitigated the expressions of tumor necrosis factoralpha (TNFalpha) and interleukin-1beta (IL-1beta) in the kidney. 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one 46-56 interleukin 1 beta Rattus norvegicus 147-155 27725274-12 2016 Mefunidone markedly decreased necrotic cell or LPS induced IL-1beta production and LPS induced TNFalpha production in primary peritoneal macrophages. 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one 0-10 interleukin 1 beta Rattus norvegicus 59-67 27683871-8 2016 In comparison with pups fed the control diet, feeding DHA at weaning resulted in a 25% lower type 1 T helper (IL-1beta) and type 2 T helper (IL-6) response by splenocytes after LPS stimulation and a 33% lower plasma concentration of ovalbumin-specific immunoglobulin (Ig) G (P < 0.05). Docosahexaenoic Acids 54-57 interleukin 1 beta Rattus norvegicus 110-118 28396300-6 2016 In the kidneys of rats with streptozotocin-induced diabets, the levels of cytokines IL-1beta, IL-6, IL-10, and PGE2 were significantly elevated above those of the control group. Streptozocin 28-42 interleukin 1 beta Rattus norvegicus 84-92 27466288-0 2016 Repeated Water Avoidance Stress Alters Mucosal Mast Cell Counts, Interleukin-1beta Levels with Sex Differences in the Distal Colon of Wistar Rats. Water 9-14 interleukin 1 beta Rattus norvegicus 65-82 26563497-7 2016 Sal could effectively decrease the levels of interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) in serum of the MCAO rats and supernatant of I/R-induced SH-SY5Y cells. rhodioloside 0-3 interleukin 1 beta Rattus norvegicus 67-84 26563497-7 2016 Sal could effectively decrease the levels of interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) in serum of the MCAO rats and supernatant of I/R-induced SH-SY5Y cells. rhodioloside 0-3 interleukin 1 beta Rattus norvegicus 86-94 27748941-7 2016 In addition, pretreatment with NaHS markedly attenuated p38MAPK/NF-kappaB-mediated cytotoxicity and inflammation, as evidenced by the significant increase in cell viability and decrease in iNOS, COX-2, IL-1beta and IL-6 expression levels. sodium bisulfide 31-35 interleukin 1 beta Rattus norvegicus 202-210 27043860-8 2016 We also found significant decreases in hepatic mRNA expression of interleukin (IL)-1beta, IL-12beta, toll-like receptor (TLR)-4 and cyclooxygenase (COX)-2 in the PV-, PI- and PS-treated groups compared with those of the EC group. Phosphorus 175-177 interleukin 1 beta Rattus norvegicus 66-88 27429048-8 2016 The expression of tumor necrosis factor alpha, IL-1beta, p38, and NR2B was up-regulated in RTX-induced neuropathic pain rat model and lasted for at least 49 days. resiniferatoxin 91-94 interleukin 1 beta Rattus norvegicus 47-55 28134940-2 2016 In the brain, inflammation is associated with expression of pro-inflammatory cytokines (e.g. tumor necrosis factor-alpha, interleukin-1beta and interleukin-6, among others) that may induce an overproduction of reactive oxygen and nitrogen species. reactive oxygen and nitrogen species 210-246 interleukin 1 beta Rattus norvegicus 122-139 27657857-6 2016 Furthermore, koumine also attenuated the increase in the expression of IL-1beta and TNF-alpha, as well as the robust increase of serum anti-CII antibodies in response to immunization. koumine 13-20 interleukin 1 beta Rattus norvegicus 71-79 27551045-12 2016 In kidney, metformin increased the activation of AMP-activated protein kinase (AMPK) and decreased inflammatory markers (COX-2 and IL-1beta) and apoptotic markers (poly(ADP-ribose) polymerase (PARP) and caspase 3). Metformin 11-20 interleukin 1 beta Rattus norvegicus 131-139 27589890-6 2016 Furthermore, edaravone reduced the levels of plasma interleukin (IL)-1beta and matrix metalloproteinase-9 at 3-h after ischemic onset. Edaravone 13-22 interleukin 1 beta Rattus norvegicus 52-74 27760517-8 2016 The intra-hippocampus and intra-BLA injections of WAY-100635 improved the delirium-like behavior of rats by significantly reducing the expression of NLRP3 inflammasome and the release of IL1-beta and IL8 into CSF. N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide 50-60 interleukin 1 beta Rattus norvegicus 187-195 27399810-0 2016 Amlodipine and atorvastatin improve ventricular hypertrophy and diastolic function via inhibiting TNF-alpha, IL-1beta and NF-kappaB inflammatory cytokine networks in elderly spontaneously hypertensive rats. Amlodipine 0-10 interleukin 1 beta Rattus norvegicus 109-117 27754317-6 2016 Moreover, pretreatment with acenocoumarol given at the dose of 50 or 100 microg/kg/dose/day reduced the AP-evoked increase in pancreatic weight, serum activity of amylase and lipase, and serum concentration of pro-inflammatory interleukin-1beta, as well as ameliorated pancreatic DNA synthesis and pancreatic blood flow. Acenocoumarol 28-41 interleukin 1 beta Rattus norvegicus 227-244 27496879-7 2016 TUDCA-treated HF rats also had lower mRNA levels for angiotensin converting enzyme, angiotensin II type 1 receptor, tumor necrosis factor-alpha, interleukin-1beta, cyclooxygenase-2, and NF-kappaB p65, and a higher mRNA level of IkappaB-alpha, in the SFO and PVN than Veh-treated HF rats. ursodoxicoltaurine 0-5 interleukin 1 beta Rattus norvegicus 145-162 27872694-8 2016 RESULTS: The results indicated that vitamin B1(150 and 200 mg/kg) attenuated the paw edema, thermal hyperalgesia, and serum levels of TNF-alpha and IL-1beta during both phases of CFA-induced inflammation in a dose-dependent manner. Thiamine 36-46 interleukin 1 beta Rattus norvegicus 148-156 27872694-9 2016 Effective dose of vitamin B1(150 mg/kg) reduced inflammatory symptoms and serum levels of TNF-alpha and IL-1beta compare to indomethacin during the chronic phase of inflammation. Thiamine 18-28 interleukin 1 beta Rattus norvegicus 104-112 27562059-11 2016 This was also reflected in changes in IL-1beta, IL-6, TNF-alpha, IGF-I, TGF-beta1, procollagen I, and procollagen III mRNAs that were decreased or trended downward in PG-PS-injected animals given anti-TNF-alpha beginning d1 or d7 compared with vehicle-treated rats; there was no effect if anti-TNF-alpha was begun d14. PG-PS 167-172 interleukin 1 beta Rattus norvegicus 38-46 27061450-6 2016 Agmatine significantly down-regulated the gene expressions of all stress-induced NLRP3 inflammasome components (NLRP3, NF-kappaB, PYCARD, caspase-1, IL-1beta and IL-18) in the hippocampus and prefrontal cortex (PFC) and reduced pro-inflammatory cytokine levels not only in both brain regions, but also in serum. Agmatine 0-8 interleukin 1 beta Rattus norvegicus 149-157 27399810-0 2016 Amlodipine and atorvastatin improve ventricular hypertrophy and diastolic function via inhibiting TNF-alpha, IL-1beta and NF-kappaB inflammatory cytokine networks in elderly spontaneously hypertensive rats. Atorvastatin 15-27 interleukin 1 beta Rattus norvegicus 109-117 27399810-8 2016 Either amlodipine or atorvastatin decreased plasma IL-1beta content in SH rats, but there was no significant difference when compared with untreated SH rats. Amlodipine 7-17 interleukin 1 beta Rattus norvegicus 51-59 27399810-8 2016 Either amlodipine or atorvastatin decreased plasma IL-1beta content in SH rats, but there was no significant difference when compared with untreated SH rats. Atorvastatin 21-33 interleukin 1 beta Rattus norvegicus 51-59 27399810-9 2016 However, the combination of amlodipine and atorvastatin significantly decreased plasma IL-1beta level in SH rats. Amlodipine 28-38 interleukin 1 beta Rattus norvegicus 87-95 27399810-9 2016 However, the combination of amlodipine and atorvastatin significantly decreased plasma IL-1beta level in SH rats. Atorvastatin 43-55 interleukin 1 beta Rattus norvegicus 87-95 27399810-10 2016 Moreover, amlodipine or atorvastatin intervention significantly reduced myocardial TNF-alpha and IL-1beta protein levels in SH rats, which was further suppressed by the combination of amlodipine and atorvastatin. Amlodipine 10-20 interleukin 1 beta Rattus norvegicus 97-105 27399810-10 2016 Moreover, amlodipine or atorvastatin intervention significantly reduced myocardial TNF-alpha and IL-1beta protein levels in SH rats, which was further suppressed by the combination of amlodipine and atorvastatin. Atorvastatin 24-36 interleukin 1 beta Rattus norvegicus 97-105 27399810-10 2016 Moreover, amlodipine or atorvastatin intervention significantly reduced myocardial TNF-alpha and IL-1beta protein levels in SH rats, which was further suppressed by the combination of amlodipine and atorvastatin. Amlodipine 184-194 interleukin 1 beta Rattus norvegicus 97-105 27399810-10 2016 Moreover, amlodipine or atorvastatin intervention significantly reduced myocardial TNF-alpha and IL-1beta protein levels in SH rats, which was further suppressed by the combination of amlodipine and atorvastatin. Atorvastatin 199-211 interleukin 1 beta Rattus norvegicus 97-105 27399810-13 2016 Our results demonstrated amlodipine and atorvastatin improved ventricular hypertrophy and diastolic function possibly through the intervention of TNF-alpha, IL-1beta, NF-kappaB/IkappaB inflammatory cytokine network. Amlodipine 25-35 interleukin 1 beta Rattus norvegicus 157-165 27399810-13 2016 Our results demonstrated amlodipine and atorvastatin improved ventricular hypertrophy and diastolic function possibly through the intervention of TNF-alpha, IL-1beta, NF-kappaB/IkappaB inflammatory cytokine network. Atorvastatin 40-52 interleukin 1 beta Rattus norvegicus 157-165 27008429-2 2016 Combining quercetin treatment with delayed transplantation of HUMSCs after local cerebral ischemia significantly (i) improved neurological functional recovery; (ii) reduced proinflammatory cytokines (interleukin(IL)-1beta and IL-6), increased anti-inflammatory cytokines (IL-4, IL-10, and transforming growth factor-beta1), and reduced ED-1 positive areas; (iii) inhibited cell apoptosis (caspase-3 expression); and (iv) improved the survival rate of HUMSCs in the injury site. Quercetin 10-19 interleukin 1 beta Rattus norvegicus 200-221 27490898-11 2016 In addition, GL suppressed the induction of the proinflammatory cytokines interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) in both cerebral regions evaluated. Glycyrrhizic Acid 13-15 interleukin 1 beta Rattus norvegicus 94-102 27703516-6 2016 However, shikonin treatment significantly inhibited the increases in IL-1beta, TNF-alpha and iNOS levels in the rats with osteoarthritis. shikonin 9-17 interleukin 1 beta Rattus norvegicus 69-77 27490898-11 2016 In addition, GL suppressed the induction of the proinflammatory cytokines interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) in both cerebral regions evaluated. Glycyrrhizic Acid 13-15 interleukin 1 beta Rattus norvegicus 74-92 26391895-5 2016 Moreover, triptolide administration suppressed macrophage infiltration, inhibited the overproduction of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and malondialdehyde (MDA) in reperfused myocardium tissues and upregulated the activities of antioxidative superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GPx). triptolide 10-20 interleukin 1 beta Rattus norvegicus 133-155 26438340-7 2016 These findings suggest that high-salt-induced NF-kappaB activation in the PVN caused hypertension via sympathoexcitation, which are associated with the increases of NLRP3, IL-1beta and oxidative stress in the PVN; PVN inhibition of NF-kappaB activity attenuates NLRP3, IL-1beta and oxidative stress in the PVN and thereby attenuates hypertension. Salts 33-37 interleukin 1 beta Rattus norvegicus 172-180 26438340-7 2016 These findings suggest that high-salt-induced NF-kappaB activation in the PVN caused hypertension via sympathoexcitation, which are associated with the increases of NLRP3, IL-1beta and oxidative stress in the PVN; PVN inhibition of NF-kappaB activity attenuates NLRP3, IL-1beta and oxidative stress in the PVN and thereby attenuates hypertension. Salts 33-37 interleukin 1 beta Rattus norvegicus 269-277 27307378-10 2016 MgSO4 treatment significantly decreased both TNF-alpha and IL-1beta concentrations, increased the latency to develop a seizure, decreased the seizure duration and shortened the EEG amplitude. Magnesium Sulfate 0-5 interleukin 1 beta Rattus norvegicus 59-67 26514127-14 2016 YM-58483 also inhibited the release of spinal cord IL-1beta, TNF-alpha, and PGE2, compared with control + vehicle (n = 5, #P < 0.001). 4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide 0-8 interleukin 1 beta Rattus norvegicus 51-59 26514127-15 2016 The analgesic mechanism of YM-58483 may be via inhibiting central ERK/CREB signaling in the neurons and decreasing central IL-1beta, TNF-alpha, and PGE2 release to reduce neuronal excitability in the spinal dorsal horn of the SNL rats. 4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide 27-35 interleukin 1 beta Rattus norvegicus 123-131 26497033-7 2016 On the contrary, Zn augmented lipid peroxidation, activity of superoxide dismutase, expression of TNF-alpha, IL-1beta, Bcl-xl, and p53-upregulated modulator of apoptosis (PUMA), and translocation of NF-kappaB and Bax from the cytosol to the nucleus and mitochondria, respectively, with concomitant increase in the mitochondrial cytochrome c release and activation of procaspase-3 and -9. Zinc 17-19 interleukin 1 beta Rattus norvegicus 109-117 27427274-8 2016 There was also down-regulation of the expression of gene for interleukin 1alpha, interleukin 1beta, interleukin 1 receptor, interleukin 6, and tumor necrosis factor alpha (TNFalpha) in the liver of rats treated with LPS as a result of hesperidin pretreatment. Hesperidin 235-245 interleukin 1 beta Rattus norvegicus 81-122 27572468-10 2016 Naringenin significantly inhibited isoflurane-induced neuroapoptosis and markedly decreased the protein expression of caspase-3, Bad, Bax, NF-kappaB, tumor necrosis factor-alpha, interleukin (IL)-6 and IL-1beta. naringenin 0-10 interleukin 1 beta Rattus norvegicus 202-210 27240474-9 2016 RESULTS: ATV decreased bone loss, reduced MPO, TNF-alpha, IL-1beta, IL-6, and IL-8, and increased IL-10, GSH, SOD, and CAT levels. Atorvastatin 9-12 interleukin 1 beta Rattus norvegicus 58-66 27712653-6 2016 In normotensive animals the activation of the cold-sensitive TRPM8 ion channel in skin by its agonist menthol without any temperature shifts causes an increase (about two fold) of pro-inflammatory cytokines IL-6 and IL-1 beta in blood without any changes in the level of TNFalpha. Menthol 102-109 interleukin 1 beta Rattus norvegicus 216-225 27363337-2 2016 It also suppressed the expression of IL-1beta-induced catabolic factors such as nitric oxide synthase 2, cyclooxygenase-2, prostaglandin E2, and inflammatory cytokines. Dinoprostone 123-139 interleukin 1 beta Rattus norvegicus 37-45 27755955-8 2016 ELISA and real-time quantitative PCR demonstrated that rapamycin inhibited ICH-induced excessive expression of TNF-alpha and IL-1beta in ipsilateral hemisphere. Sirolimus 55-64 interleukin 1 beta Rattus norvegicus 125-133 27474069-5 2016 The study was extended further for determination of tissue levels of TNF-alpha and expression of IL-1beta, IL-6 and NFkappaB (p65) in ethanol induced gastric ulcer model. Ethanol 134-141 interleukin 1 beta Rattus norvegicus 97-105 27474069-9 2016 Furthermore, artesunate pretreatment also alleviated the gastric mucosal inflammation as revealed by significant decrease in the tissue level of pro-inflammatory cytokine TNF-alpha (p < 0.01) and tissue expression of IL-1beta, IL-6 and NFkappaB (p65). Artesunate 13-23 interleukin 1 beta Rattus norvegicus 220-228 27656145-10 2016 ZJME at 200, 400 mg/kg and ZJWF at 50, 100 mg/kg inhibited the lipid peroxidation and significantly restored the liver function markers (AST, ALT, ALP, LDH, SOD, and CAT) and cytokine levels (TNF-alpha, Il-1beta, and Il-10) in CCl4 induced acute liver damage in rats. zjwf 27-31 interleukin 1 beta Rattus norvegicus 203-211 27657030-6 2016 WECC at 200 mg/kg significantly suppressed the activation of astrocytes and microglia and decreased the expression levels of IL-1beta and TNF in the spinal cord after injection with oxaliplatin. Oxaliplatin 182-193 interleukin 1 beta Rattus norvegicus 125-133 27497920-9 2016 Simultaneously, ketamine reduced the levels of IL-6, IL-1beta, IDO, and KYN/TRP ratio and increased the 5-HT/TRP ratio in the hippocampus. Ketamine 16-24 interleukin 1 beta Rattus norvegicus 53-61 27704348-7 2016 A progressive decrease in the content of proinflammatory cytokines (IL-1beta and TNF-alpha) was observed by day 10 after endoprosthesis implantation, this decrease being more manifest in response to polytetrafluoroethylene. Polytetrafluoroethylene 199-222 interleukin 1 beta Rattus norvegicus 68-76 27128308-4 2016 Results show that sesamin significantly inhibits the lipopolysaccharide (LPS)-induced expression of catabolic enzymes (MMP-1, MMP-3, MMP-13, ADAMTS-4, ADAMTS-5) and inflammation factors (IL-1beta, TNF-alpha, iNOS, NO, COX-2, PGE2) in a dose-dependent manner in vitro. sesamin 18-25 interleukin 1 beta Rattus norvegicus 187-195 27128308-7 2016 Moreover, sesamin suppresses LPS-induced activation of the mitogen-activated protein kinase (MAPK) pathway through inhibiting phosphorylation of JNK, the common downstream signaling pathway of LPS and IL-1beta, which may be the potential mechanism of the effects of sesamin. sesamin 10-17 interleukin 1 beta Rattus norvegicus 201-209 27588105-14 2016 Furthermore, DOX provoked inflammatory responses by increasing the expression levels of IL-1beta, IL-6, NF-kappaB and tumor necrosis factor-alpha, whereas vitexin pretreatment significantly inhibited these inflammatory responses. Doxorubicin 13-16 interleukin 1 beta Rattus norvegicus 88-96 27169686-6 2016 In this study, expression of NOD1, RICK, IkappaBalpha, NF-kappaB and IL-1beta was detected in cultured rat glomerular mesangial cells (rGMCs) stimulated with high concentrations of glucose and LPS. Glucose 181-188 interleukin 1 beta Rattus norvegicus 69-77 27169686-8 2016 Our results showed that high glucose or LPS increased the protein and mRNA expression of NOD1, RICK,NF-kappaBp65 and IL-1beta, but attenuated IkappaBalpha expression (P<0.05). Glucose 29-36 interleukin 1 beta Rattus norvegicus 117-125 26500219-0 2016 Ethanol attenuates vasorelaxation via inhibition of inducible nitric oxide synthase in rat artery exposed to interleukin-1beta. Ethanol 0-7 interleukin 1 beta Rattus norvegicus 109-126 26500219-4 2016 The present study aimed to elucidate the effect of EtOH on gradual relaxation and iNOS expression induced by IL-1beta in isolated rat superior mesenteric arteries (SMAs). Ethanol 51-55 interleukin 1 beta Rattus norvegicus 109-117 26500219-5 2016 Exposure to IL-1beta-induced contraction in SMA rings, followed by a gradual relaxation of phenylephrine precontracted tone. Phenylephrine 91-104 interleukin 1 beta Rattus norvegicus 12-20 26500219-13 2016 Taken together, EtOH inhibits IL-1beta-mediated vasorelaxation by suppressing endothelium iNOS expression. Ethanol 16-20 interleukin 1 beta Rattus norvegicus 30-38 26500219-14 2016 This study provides the first evidence of EtOH -induced inhibition of IL-1beta-mediated vasorelaxation. Ethanol 42-46 interleukin 1 beta Rattus norvegicus 70-78 27598133-6 2016 Administration of ghrelin after induction of colitis led to faster regeneration of the colonic wall and reduction in colonic levels of IL-1beta, TNF-alpha, and myeloperoxidase. Ghrelin 18-25 interleukin 1 beta Rattus norvegicus 135-143 27485077-5 2016 RESULTS: OLETF rats treated with the vaccine reduced blood glucose levels, improved renal pathological changes, and inhibited overexpression of TGF-beta1 and p-Smad3, as well as MCP-1, TNF-alpha and IL-1beta. oletf 9-14 interleukin 1 beta Rattus norvegicus 199-207 27812611-6 2016 Results:: The levels of MDA, IL-1beta, and TNF-alpha were found to be significantly higher in the cheek, lower lip, and tongue tissue of the animals receiving MTX, compared with HG and HMTX groups; however, these parameters were lower in the cheek and low lip tissue, and a milder damage ocurred in these tissues, compared with the tongue tissue in MTXC group. Methotrexate 159-162 interleukin 1 beta Rattus norvegicus 29-37 27430346-10 2016 Pre-treatment with cannabidiol suppressed the promotion of COX-2, iNOS, IL-1beta and IL-6 expression in the nucleus pulposus cells following H2O2 exposure. Cannabidiol 19-30 interleukin 1 beta Rattus norvegicus 72-80 27430552-8 2016 In addition, sivelestat suppressed the CLP-induced macrophage infiltration, the overproduction of pro-inflammatory mediators (tumor necrosis factor-alpha, interleukin-1beta, high-mobility group box 1 and inducible nitric oxide synthase) and serine/threonine kinase (Akt) pathway activation in the rats. sivelestat 13-23 interleukin 1 beta Rattus norvegicus 155-172 27430724-11 2016 CIF stimulated the expression of hyaluronan synthase (HAS)1 and 2, lubricin, collagen I, versican, aggrecan, matrix metalloproteinases (MMPs)2 and 3, tissue inhibitors of metalloproteinases (TIMPs) 1-3, interleukin (IL)-6 and TGFbeta1, and decreased the expression of tumor necrosis factor (TNF) and IL-1beta. cif 0-3 interleukin 1 beta Rattus norvegicus 300-308 25754438-3 2016 In inflamed liver, proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta stimulate the induction of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production. Nitric Oxide 151-163 interleukin 1 beta Rattus norvegicus 91-113 27344040-0 2016 Lectin from Abelmoschus esculentus reduces zymosan-induced temporomandibular joint inflammatory hypernociception in rats via heme oxygenase-1 pathway integrity and tnf-alpha and il-1beta suppression. Zymosan 43-50 interleukin 1 beta Rattus norvegicus 178-186 27431944-3 2016 The present study therefore examined the effects of TSA on the expression levels of interleukin-1beta (IL-1beta)-induced matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in vitro and in vivo. trichostatin A 52-55 interleukin 1 beta Rattus norvegicus 84-101 27431944-3 2016 The present study therefore examined the effects of TSA on the expression levels of interleukin-1beta (IL-1beta)-induced matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in vitro and in vivo. trichostatin A 52-55 interleukin 1 beta Rattus norvegicus 103-111 27431944-7 2016 Chondrocytes treated with IL-1beta demonstrated increased mRNA and protein expression levels of MMP-1, MMP-3 and MMP-13, and decreased expression levels of TIMP-1 mRNA and protein; these alterations were significantly attenuated by TSA treatment. trichostatin A 232-235 interleukin 1 beta Rattus norvegicus 26-34 27430346-10 2016 Pre-treatment with cannabidiol suppressed the promotion of COX-2, iNOS, IL-1beta and IL-6 expression in the nucleus pulposus cells following H2O2 exposure. Hydrogen Peroxide 141-145 interleukin 1 beta Rattus norvegicus 72-80 27230882-8 2016 However, IL-1beta and IFN-gamma levels were higher in animals treated with haloperidol than risperidone. Haloperidol 75-86 interleukin 1 beta Rattus norvegicus 9-17 26253724-9 2016 The levels of IL-1beta and IL-6 protein expression in OX-42-labeled microglial cells were significantly increased in the cortex and hippocampus of rats exposed to fluoride, and TNF-alpha immunoreactivity in microglial cells of the hippocampus was significantly higher in the 120 ppm fluoride-treated group than that in the control group. Fluorides 163-171 interleukin 1 beta Rattus norvegicus 14-22 26253724-9 2016 The levels of IL-1beta and IL-6 protein expression in OX-42-labeled microglial cells were significantly increased in the cortex and hippocampus of rats exposed to fluoride, and TNF-alpha immunoreactivity in microglial cells of the hippocampus was significantly higher in the 120 ppm fluoride-treated group than that in the control group. Fluorides 283-291 interleukin 1 beta Rattus norvegicus 14-22 27209303-7 2016 NR treatment significantly attenuated DOX-induced raised plasma corticosterone (CORT), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) levels in the hippocampus (HC). Doxorubicin 38-41 interleukin 1 beta Rattus norvegicus 131-149 27209303-7 2016 NR treatment significantly attenuated DOX-induced raised plasma corticosterone (CORT), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) levels in the hippocampus (HC). Doxorubicin 38-41 interleukin 1 beta Rattus norvegicus 151-159 27245167-5 2016 Meloxicam mitigated CCl4-induced elevation in hepatic levels of nuclear factor kappa B (NF-kappaB), tumor necrosis factor alpha (TNF-alpha), total nitric oxide (NO), interleukin-l beta (IL 1beta), and prostaglandin E2 (PGE2). Meloxicam 0-9 interleukin 1 beta Rattus norvegicus 186-194 27230882-8 2016 However, IL-1beta and IFN-gamma levels were higher in animals treated with haloperidol than risperidone. Risperidone 92-103 interleukin 1 beta Rattus norvegicus 9-17 27245167-9 2016 The antifibrotic mechanism of meloxicam could be through decreasing NF-kappaB level and subsequent proinflammatory cytokine production (TNF-alpha, NO, IL-1 beta, and PGE2) and, hence, collagen deposition through inhibition of TIMP-1 and TGF-beta. Meloxicam 30-39 interleukin 1 beta Rattus norvegicus 151-160 27324074-9 2016 Pretreatment with zVAD-fmk significantly inhibited a post-SAP increase in the activation of MPO, TNF-alpha, IL-1beta, and caspase-3, and decreased lung injury induced by SAP as determined by the pathologic score. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 18-26 interleukin 1 beta Rattus norvegicus 108-116 27178879-7 2016 Topical application of curcumin-emu oil combination resulted in significant reduced levels of proinflammatory mediators TNF-alpha, IL-1 beta, and IL-6 (P < 0.05, 0.001, and 0.01, respectively) compared to arthritic animals. curcumin-emu oil 23-39 interleukin 1 beta Rattus norvegicus 131-140 27180880-11 2016 Our data also demonstrated that GMI inhibited pro-inflammatory cytokines such as TNF-alpha, IL-1beta and IL-6, regulated the expression of iNOS and COX-2 compared with those in the CIA group. misonidazole-glutathione conjugate 32-35 interleukin 1 beta Rattus norvegicus 92-100 27163523-0 2016 Effects of interleukin-1 beta injections into the subfornical organ and median preoptic nucleus on sodium appetite, blood pressure and body temperature of sodium-depleted rats. Sodium 99-105 interleukin 1 beta Rattus norvegicus 11-29 27163523-3 2016 The aim of the present study was to investigate the effects of IL-1beta injections directly into the subfornical organ (SFO) and the median preoptic nucleus (MnPO) on salt appetite, hedonic response, locomotion, body temperature and blood pressure in sodium-depleted rats. Salts 167-171 interleukin 1 beta Rattus norvegicus 63-71 27163523-4 2016 IL-1beta injections into the SFO and MnPO at the doses of 0.2, 0.4, 0.8 and 1.6ng/0.2mul promoted a dose-dependent inhibition of salt intake in sodium-depleted rats. Salts 129-133 interleukin 1 beta Rattus norvegicus 0-8 27163523-4 2016 IL-1beta injections into the SFO and MnPO at the doses of 0.2, 0.4, 0.8 and 1.6ng/0.2mul promoted a dose-dependent inhibition of salt intake in sodium-depleted rats. Sodium 144-150 interleukin 1 beta Rattus norvegicus 0-8 27163523-10 2016 Further studies are required to clarify the mechanisms involved in fever, blood pressure increase and inhibition of sodium appetite induced by injections of IL-1beta into the SFO and MnPO in sodium-depleted rats. Sodium 116-122 interleukin 1 beta Rattus norvegicus 157-165 27163523-10 2016 Further studies are required to clarify the mechanisms involved in fever, blood pressure increase and inhibition of sodium appetite induced by injections of IL-1beta into the SFO and MnPO in sodium-depleted rats. Sodium 191-197 interleukin 1 beta Rattus norvegicus 157-165 27180133-11 2016 injection of 100mug/5mul FAM-20 had a significant increase in the concentration of IL-1beta in both the hypothalamus and the hippocampus for ~27h after injection. fam-20 25-31 interleukin 1 beta Rattus norvegicus 83-91 28925130-4 2016 The results showed that ethyl acetate portion of unripe Forsythiae Fructus had a better anti-inflammatory activity against acute lung injury, and could suppress the release of inflammatory factors of IL-6, TNF-alpha, IL-1beta, significantly reduce contents of creatine, beta-OH-butyrate, succinate, lysine, valine, isoleucine and glutamine, and elevate the content of GPC in serum. ethyl acetate 24-37 interleukin 1 beta Rattus norvegicus 217-225 26853745-7 2016 Results Compared with the model group, VOAS and Dex significantly accelerated the recovery of the exterior behaviour, the liver pathological changes of rats, and increased the level of IL-10, but decreased the level of WBC, NE%, GOT, GPT, ALP, TNF-alpha, IL-1beta, IL-6, HIS, 5-HT, NO, PGE2, iNOS and COX-2 (p < 0.05). Dexamethasone 48-51 interleukin 1 beta Rattus norvegicus 255-263 27562050-7 2016 Moreover, oxycodone decreased the productions of the inflammatory cytokines including IL-1beta, TNF-alpha, HMGB-1((1 208+-18)pg/ml, (1 660+-14) pg/ml, (61+-4) pg/ml , all P<0.05). Oxycodone 10-19 interleukin 1 beta Rattus norvegicus 86-94 27368151-9 2016 Caffeic acid administration protected livers against histopathological injury, decreased plasma ALT, AST, and ALP levels, decreased TNF-alpha, IL-6, IL-1beta and LTs levels, increased the reactive oxygen species content, and down-regulated the mRNA and protein expressions of 5-LO in aluminum overloaded rats. caffeic acid 0-12 interleukin 1 beta Rattus norvegicus 149-157 27525946-11 2016 Pterostilbene reduced serum levels of TNF-a and IL-1b; decreased NF-kB gene expression, serum indices, and ROS generation; and increased SOD activity in a dose-dependent manner. pterostilbene 0-13 interleukin 1 beta Rattus norvegicus 48-53 27509307-12 2016 Furthermore, serum IL-1beta, IL-6, TNF-alpha, AMY and LIP levels and tissue MPO activity were significantly decreased in the galunisertib-treated group. LY-2157299 125-137 interleukin 1 beta Rattus norvegicus 19-27 27180880-13 2016 CONCLUSION: Taken together, our results shed light on the therapeutic efficacy of GMI in rats rheumatoid arthritis model by reducing the levels of IL-1beta, IL-6 and TNF-alpha in serum as well as down-regulating the levels of iNOS and COX-2. misonidazole-glutathione conjugate 82-85 interleukin 1 beta Rattus norvegicus 147-155 27470331-8 2016 RESULTS: Ligustrazine downregulated the levels of TNF-alpha, IL-1beta, IL-6. tetramethylpyrazine 9-21 interleukin 1 beta Rattus norvegicus 61-69 27184601-7 2016 On the other hand, the treatment with the AM receptor agonist AM1-50 (10nM) for 96h induced an increase in the level of GFAP, IL-1beta, pCREB and pNF-kappaB proteins. am1-50 62-68 interleukin 1 beta Rattus norvegicus 126-134 26928198-2 2016 However, clenbuterol is also known to increase the expression of IL-1beta in the brain, a potent neuromodulator that plays a role in provoking sickness related symptoms including anxiety and depression-related behaviours. Clenbuterol 9-20 interleukin 1 beta Rattus norvegicus 65-73 27163720-6 2016 Dexmedetomidine pretreatment significantly suppressed the inflammatory responses, as evidenced by lower TNF-alpha and IL-1beta levels, significantly inhibited NF-kappaB activity, and alleviated overexpression of microglia and astrocytes in the hippocampus. Dexmedetomidine 0-15 interleukin 1 beta Rattus norvegicus 118-126 27214098-8 2016 RESULT: Cytokines such as IL-1beta, IL-10, and TGFbeta were 3.7+-0.9-fold, 3.4+-1.2-fold, and 1.2+-0.1-fold higher in APS, respectively, compared with naive platelet supernatant. aps 118-121 interleukin 1 beta Rattus norvegicus 26-34 27149420-12 2016 Atorvastatin markedly downregulated IL-1beta, TNF-alpha, iNOS, and NGF and upregulated Arg1, shifting the macrophage phenotype from M1 to M2. Atorvastatin 0-12 interleukin 1 beta Rattus norvegicus 36-44 27149420-14 2016 CONCLUSION: Atorvastatin effectively ameliorated cardiac sympathetic nerve remodeling and prevented VAs after MI by significantly downregulating the expression of NGF, IL-1beta, and TNF-alpha via together with the augmentation of M2 macrophage. Atorvastatin 12-24 interleukin 1 beta Rattus norvegicus 168-176 26909502-5 2016 Treatment with Salidroside (Sal, 20, 40 mg/kg) for 28 days ameliorated D-gal-induced memory deficits and inflammatory mediators including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). rhodioloside 15-26 interleukin 1 beta Rattus norvegicus 182-199 27223823-5 2016 Microinjection into RVLM of IL-1beta suppressed the expressions of p-Nrf2 and TFAM, and evoked a pressor response; conversely, the Nrf2 inducer, tert-butylhydroquinone, lessened the LPS-induced suppression of TFAM expression and pressor response. 2-tert-butylhydroquinone 145-167 interleukin 1 beta Rattus norvegicus 28-36 27445100-0 2016 Angiotensin(1-7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1beta/Smad circuit. nox 80-83 interleukin 1 beta Rattus norvegicus 126-134 27445100-0 2016 Angiotensin(1-7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1beta/Smad circuit. Hydrogen Peroxide 92-96 interleukin 1 beta Rattus norvegicus 126-134 27446319-13 2016 Atorvastatin, and LMWH may therefore be useful for the treatment of sepsis due to its ability to inhibit the release of TNF-alpha, IL-1beta and HMGB1 in septic rats. Atorvastatin 0-12 interleukin 1 beta Rattus norvegicus 131-139 27446319-13 2016 Atorvastatin, and LMWH may therefore be useful for the treatment of sepsis due to its ability to inhibit the release of TNF-alpha, IL-1beta and HMGB1 in septic rats. Heparin, Low-Molecular-Weight 18-22 interleukin 1 beta Rattus norvegicus 131-139 26909502-5 2016 Treatment with Salidroside (Sal, 20, 40 mg/kg) for 28 days ameliorated D-gal-induced memory deficits and inflammatory mediators including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). rhodioloside 15-18 interleukin 1 beta Rattus norvegicus 182-199 27068033-6 2016 Blockage of JAK and p38/JNK/ERK MAPKs with their specific inhibitors, AG490, SB202190, SP600125 and U0126 significantly reduced PM-induced iNOS expression and IL-1beta production. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 77-85 interleukin 1 beta Rattus norvegicus 159-167 27068033-6 2016 Blockage of JAK and p38/JNK/ERK MAPKs with their specific inhibitors, AG490, SB202190, SP600125 and U0126 significantly reduced PM-induced iNOS expression and IL-1beta production. pyrazolanthrone 87-95 interleukin 1 beta Rattus norvegicus 159-167 27068033-6 2016 Blockage of JAK and p38/JNK/ERK MAPKs with their specific inhibitors, AG490, SB202190, SP600125 and U0126 significantly reduced PM-induced iNOS expression and IL-1beta production. U 0126 100-105 interleukin 1 beta Rattus norvegicus 159-167 27483221-4 2016 Among the two synthetic spirosteroid analogues, only the (25R)-5alpha-spirostan-3,6-one (S15) protected PC12 against ischemia-related in vitro models and inhibited NO production, as well as the release of IL-1beta by stimulated primary microglia. (25r)-5alpha-spirostan-3,6-one 57-87 interleukin 1 beta Rattus norvegicus 205-213 27075430-7 2016 The administration of NAC blocked the maturation of interleukin-1beta, which is a critical substrate of MMPs, and markedly suppressed the neuronal activation induced by CCI, including inhibiting the phosphorylation of protein kinase Cgamma, NMDAR1, and mitogen-activated protein kinases. Acetylcysteine 22-25 interleukin 1 beta Rattus norvegicus 52-69 26863032-12 2016 Plasma levels of IL-1beta, IL-5, IL-6, TNF-alpha, and HMGB1 were attenuated by NaHS. sodium bisulfide 79-83 interleukin 1 beta Rattus norvegicus 17-25 27524893-7 2016 NiONP-induced IL-1beta secretion was partially prevented by co-treatment with a caspase-1 inhibitor in macrophages. nionp 0-5 interleukin 1 beta Rattus norvegicus 14-22 27493629-5 2016 Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1beta (IL-1beta) and CNS markers after LPS exposure in aged rats. pyrrolidine dithiocarbamic acid 52-79 interleukin 1 beta Rattus norvegicus 202-219 27493629-5 2016 Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1beta (IL-1beta) and CNS markers after LPS exposure in aged rats. pyrrolidine dithiocarbamic acid 52-79 interleukin 1 beta Rattus norvegicus 221-229 27493629-5 2016 Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1beta (IL-1beta) and CNS markers after LPS exposure in aged rats. pyrrolidine dithiocarbamic acid 81-85 interleukin 1 beta Rattus norvegicus 202-219 27493629-5 2016 Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kappaB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1beta (IL-1beta) and CNS markers after LPS exposure in aged rats. pyrrolidine dithiocarbamic acid 81-85 interleukin 1 beta Rattus norvegicus 221-229 27435304-5 2016 Omeprazole significantly decreased the levels of tumor necrosis factor (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) as compared to their respective control groups. Omeprazole 0-10 interleukin 1 beta Rattus norvegicus 84-101 27435304-7 2016 Similarly, in-vitro study, LPS mediated ROS-induced U-87 cells, omeprazole reduced the oxidative stress as well as the release of TNF-alpha, IL-1beta and IL-6. Omeprazole 64-74 interleukin 1 beta Rattus norvegicus 141-149 27435304-5 2016 Omeprazole significantly decreased the levels of tumor necrosis factor (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) as compared to their respective control groups. Omeprazole 0-10 interleukin 1 beta Rattus norvegicus 103-111 27174766-10 2016 In concert with these results, we highlighted that the secretion of IL-1beta and STAT3 activation induced by Arsenic trioxide can be mediated by elevation of P38/JNK MAPK in HAPI microglia cells and then induced the toxicity of neurons. Arsenic Trioxide 109-125 interleukin 1 beta Rattus norvegicus 68-76 27266851-11 2016 CEP, Pip or their combination showed significant inhibition of NF-kappaB together with decreased IL-1beta and TNF-alpha levels in diabetic rats. piperine 5-8 interleukin 1 beta Rattus norvegicus 97-105 27464631-13 2016 The content of TNF-alpha and IL-1beta in culture supernatant of macrophages of rats in sodium hydrosulfide+ PPG group was obviously higher than that of sodium hydrosulfide group but obviously lower than that of group PPG at each time point (with P values below 0.01), reaching the nadir on PID 14 at (488+-16) and (144+-6) pg/mL respectively. sodium bisulfide 87-106 interleukin 1 beta Rattus norvegicus 29-37 27464631-13 2016 The content of TNF-alpha and IL-1beta in culture supernatant of macrophages of rats in sodium hydrosulfide+ PPG group was obviously higher than that of sodium hydrosulfide group but obviously lower than that of group PPG at each time point (with P values below 0.01), reaching the nadir on PID 14 at (488+-16) and (144+-6) pg/mL respectively. propargylglycine 108-111 interleukin 1 beta Rattus norvegicus 29-37 27464631-13 2016 The content of TNF-alpha and IL-1beta in culture supernatant of macrophages of rats in sodium hydrosulfide+ PPG group was obviously higher than that of sodium hydrosulfide group but obviously lower than that of group PPG at each time point (with P values below 0.01), reaching the nadir on PID 14 at (488+-16) and (144+-6) pg/mL respectively. sodium bisulfide 152-171 interleukin 1 beta Rattus norvegicus 29-37 27464631-13 2016 The content of TNF-alpha and IL-1beta in culture supernatant of macrophages of rats in sodium hydrosulfide+ PPG group was obviously higher than that of sodium hydrosulfide group but obviously lower than that of group PPG at each time point (with P values below 0.01), reaching the nadir on PID 14 at (488+-16) and (144+-6) pg/mL respectively. propargylglycine 217-220 interleukin 1 beta Rattus norvegicus 29-37 27464631-14 2016 CONCLUSIONS: Supplementation of exogenous hydrogen sulfide in small dosage can increase the secretion of growth factors bFGF and TGF-beta1 in macrophages of wound in rats with deep partial-thickness burn in the early stage and reduce the release of inflammatory mediators TNF-alpha and IL-1beta in the meantime, thus affecting the healing of wound. Hydrogen Sulfide 42-58 interleukin 1 beta Rattus norvegicus 286-294 27174766-4 2016 In this study, using ELISA, we showed that Arsenic trioxide up-regulated the expression and secretion of IL-1beta in a dose-dependent manner and a time-dependent manner in cultured HAPI microglia cells. Arsenic Trioxide 43-59 interleukin 1 beta Rattus norvegicus 105-113 27424012-7 2016 Levels of TNF-alpha and IL-1beta were significantly increased in the renal tissue in cisplatin group. Cisplatin 85-94 interleukin 1 beta Rattus norvegicus 24-32 29441918-9 2016 Additionally, the elevated levels of TNF-alpha, IL-1beta, and IL-2 in CCI spinal cord were inhibited by ligustrazine. tetramethylpyrazine 104-116 interleukin 1 beta Rattus norvegicus 48-56 26304161-7 2016 These findings suggest that IL-1beta activation in the PVN plays a role in salt-sensitive hypertension. Salts 75-79 interleukin 1 beta Rattus norvegicus 28-36 26747719-9 2016 In addition, DHA promoted a reduction in the expression of interleukin (IL) 1beta and an increase in the expression of IL-6. Docosahexaenoic Acids 13-16 interleukin 1 beta Rattus norvegicus 59-81 23884077-8 2016 Furthermore, ketotifen significantly decreased proinflammatory mediators, including nitric oxide, interleukin-1beta, and interleukin-6, production in MSU-treated rats. Ketotifen 13-22 interleukin 1 beta Rattus norvegicus 98-115 23884077-8 2016 Furthermore, ketotifen significantly decreased proinflammatory mediators, including nitric oxide, interleukin-1beta, and interleukin-6, production in MSU-treated rats. Uric Acid 150-153 interleukin 1 beta Rattus norvegicus 98-115 27261609-6 2016 Juglanin exerted prevention of fructose-feeding-stimulated increased LPS levels, accelerated alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) and up-regulated inflammatory cytokines expression in serum, mainly including tumor necrosis factor-alpha (TNF-a), Interleukin 1beta (IL-1beta), Interleukin 6 (IL-6) and Interleukin 18 (IL-18). juglanin 0-8 interleukin 1 beta Rattus norvegicus 296-313 27261609-6 2016 Juglanin exerted prevention of fructose-feeding-stimulated increased LPS levels, accelerated alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) and up-regulated inflammatory cytokines expression in serum, mainly including tumor necrosis factor-alpha (TNF-a), Interleukin 1beta (IL-1beta), Interleukin 6 (IL-6) and Interleukin 18 (IL-18). juglanin 0-8 interleukin 1 beta Rattus norvegicus 315-323 27261609-6 2016 Juglanin exerted prevention of fructose-feeding-stimulated increased LPS levels, accelerated alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) and up-regulated inflammatory cytokines expression in serum, mainly including tumor necrosis factor-alpha (TNF-a), Interleukin 1beta (IL-1beta), Interleukin 6 (IL-6) and Interleukin 18 (IL-18). Fructose 31-39 interleukin 1 beta Rattus norvegicus 296-313 27261609-6 2016 Juglanin exerted prevention of fructose-feeding-stimulated increased LPS levels, accelerated alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) and up-regulated inflammatory cytokines expression in serum, mainly including tumor necrosis factor-alpha (TNF-a), Interleukin 1beta (IL-1beta), Interleukin 6 (IL-6) and Interleukin 18 (IL-18). Fructose 31-39 interleukin 1 beta Rattus norvegicus 315-323 27346278-5 2016 We found that ZDF rats became hyperglycemic and exhibited increased levels of TNFalpha, IL-1beta, and NFkappaB in the RVM at the age of 13 weeks. zdf 14-17 interleukin 1 beta Rattus norvegicus 88-96 27346278-6 2016 Intra-RVM administrations of thalidomide dose-dependently attenuated mechanical allodynia and thermal hyperalgesia, and this phenomenon was associated with reduced levels of TNFalpha, IL-1beta, and NFkappaB in the RVM, without altering serum levels of TNFalpha or IL-1beta. Thalidomide 29-40 interleukin 1 beta Rattus norvegicus 184-192 27346278-6 2016 Intra-RVM administrations of thalidomide dose-dependently attenuated mechanical allodynia and thermal hyperalgesia, and this phenomenon was associated with reduced levels of TNFalpha, IL-1beta, and NFkappaB in the RVM, without altering serum levels of TNFalpha or IL-1beta. Thalidomide 29-40 interleukin 1 beta Rattus norvegicus 264-272 27346278-7 2016 These results suggested that supraspinal mechanisms of thalidomide play a critical role in modulations of type 2 diabetes induced neuropathic pain, which is likely mediated by TNFalpha and IL-1beta in the RVM. Thalidomide 55-66 interleukin 1 beta Rattus norvegicus 189-197 26224360-6 2016 The results indicated that MIS joint LCL treatment showed enhanced therapeutic effects against ICH-induced inflammation injury and apoptosis in rats, as convinced by the decline of TUNEL-positive cells, followed by the decrease of IL-1beta and LDH and increase of IL-10 and SOD. dextramycine 37-40 interleukin 1 beta Rattus norvegicus 231-239 26304161-0 2016 Targeting Interleukin-1 beta to Suppress Sympathoexcitation in Hypothalamic Paraventricular Nucleus in Dahl Salt-Sensitive Hypertensive Rats. Salts 108-112 interleukin 1 beta Rattus norvegicus 10-28 27104804-13 2016 This study found that ACZ could decrease the content of pro-inflammatory cytokines, such as MCP-1, IL-1beta, TNF-alpha and IFN-gamma in rat lungs, and, the lung injury in the HA+ACZ group reduced. Acetazolamide 22-25 interleukin 1 beta Rattus norvegicus 99-107 26304161-2 2016 In this study, we determined whether interleukin-1 beta (IL-1beta) activation within the PVN contributes to sympathoexcitation during development of salt-dependent hypertension. Salts 149-153 interleukin 1 beta Rattus norvegicus 37-55 26304161-2 2016 In this study, we determined whether interleukin-1 beta (IL-1beta) activation within the PVN contributes to sympathoexcitation during development of salt-dependent hypertension. Salts 149-153 interleukin 1 beta Rattus norvegicus 57-65 27310207-3 2016 Punicalagin significantly and dose-dependently reduced the elevations of serum alanine aminotransferase, and liver nuclear factor-kappaB p65, tumor necrosis factor-alpha, interleukin-1beta, malondialdehyde, nitric oxide, Bax/Bcl-2 ratio, inducible nitric oxide synthase, caspases 3 and 9 activities, and prevented the decrease of hepatic total antioxidant capacity. punicalagin 0-11 interleukin 1 beta Rattus norvegicus 171-188 27347079-7 2016 Furthermore, isoflurane exposure induced marked upregulation of proinflammatory cytokines, including interleukin (IL)-1beta, TNF-alpha, IL-6 and IL-8 in the hippocampus tissue. Isoflurane 13-23 interleukin 1 beta Rattus norvegicus 101-123 27135545-9 2016 Therefore, pro-inflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta levels were measured and it has been shown that PGE1 suppressed both cytokines. Alprostadil 136-140 interleukin 1 beta Rattus norvegicus 70-87 27109342-8 2016 Furthermore, taraxasterol significantly inhibited the overproduction of serum TNF-alpha, IL-1beta, PGE2 and RANKL, and increased serum OPG production in FCA-induced rats. taraxasterol 13-25 interleukin 1 beta Rattus norvegicus 89-97 27125588-8 2016 CONCLUSION: The polysaccharide-rich extract of C. ferra stem barks accelerates wound healing by the control of the inflammatory phase and attenuates hypernociception via modulation of inflammatory mediators (TNF-alpha, IL-1beta, NO, TGF-beta). Polysaccharides 16-30 interleukin 1 beta Rattus norvegicus 219-227 26864306-6 2016 Furthermore, FIR inhibited both the NLRP3 inflammasome and the production of IL-1beta in lipopolysaccharide-activated THP-1 macrophages. fir 13-16 interleukin 1 beta Rattus norvegicus 77-85 27382352-6 2016 IBU administration signifi cantly decreased the expression of pro-inflammatory mediators, such as tumor necrosis factor-alpha, interleukin-1beta, and BDNF, in the hippocampus, as assessed by reverse transcription-polymerase chain reaction analysis and immunohistochemistry. Ibuprofen 0-3 interleukin 1 beta Rattus norvegicus 127-144 26961891-6 2016 At the molecular analysis, the levels of IL-1beta and of IL-4 in the hippocampus were decreased and enhanced, respectively, by the treatment with silibinin. Silybin 146-155 interleukin 1 beta Rattus norvegicus 41-49 27107801-6 2016 Treatment with 100 or 200mg/kg/day baicalin dramatically reduced the alveolar bone loss, the levels of HMGB1, TNF-alpha, IL-1beta, and MPO expression, and the numbers of inflammatory infiltrates in the gingival tissues. baicalin 35-43 interleukin 1 beta Rattus norvegicus 121-129 27214337-6 2016 It was also observed that administration of rhodioloside (20, 40mg/kg) decreased pro-inflammatory cytokines interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6) levels and inhibits nuclear factor-kappa B (NF-kappaB) activation, as well as normalized the monoaminergic system changes in prefrontal cortex (PFC) of OBX rats. rhodioloside 44-56 interleukin 1 beta Rattus norvegicus 108-126 27214337-6 2016 It was also observed that administration of rhodioloside (20, 40mg/kg) decreased pro-inflammatory cytokines interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6) levels and inhibits nuclear factor-kappa B (NF-kappaB) activation, as well as normalized the monoaminergic system changes in prefrontal cortex (PFC) of OBX rats. rhodioloside 44-56 interleukin 1 beta Rattus norvegicus 128-136 27018398-10 2016 Furthermore, the BAM8-22 exposure suppressed the lipopolysaccharide (LPS)-induced increase of nNOS and IL-1beta in the DRG explant cultures and the BAM8-22-induced suppression disappeared in the presence of MrgC receptor antibody. bovine adrenal medulla 8-22 17-24 interleukin 1 beta Rattus norvegicus 103-111 27316538-11 2016 Compared with the control group, DcR3.Fc-treated rats had increased vascularization at the injury epicenter along with higher levels of interleukin (IL)-4 and IL-10 and lower level of IL-1beta on DcR3.Fc-treated rats at day 7 after SCI. Fc(alpha) receptor 38-40 interleukin 1 beta Rattus norvegicus 184-192 27342775-17 2016 In addition, histidine treatment initiated immediately, but not 3 days after PSL, inhibited microglial activation and IL-1beta upregulation in the lumbar spinal cord, in parallel with its effects on behavioral hypersensitivity. Histidine 13-22 interleukin 1 beta Rattus norvegicus 118-126 27357391-12 2016 The immunohistochemical and biochemical results show that minocycline inhibited IFN-alpha-induced microglial activation and reduced IL-1beta and TNF-alpha production. Minocycline 58-69 interleukin 1 beta Rattus norvegicus 132-140 27060631-13 2016 The compound of paeoniflorin, a major bioactive compound in SFZYD, was proved to regulate the MAPK signaling pathway by inhibiting the expression of IL-1beta, IL-2, IL-10, IL-12, TNFalpha, INFgamma, c-jun and c-fos in PHA stimulated-PBMC. peoniflorin 16-28 interleukin 1 beta Rattus norvegicus 149-157 26996510-7 2016 Furthermore, both alcohol-exposed and SI animals had increased levels of pro-inflammatory cytokines IL-1beta, TNF-alpha, CD11b, and CCL4; in addition, CCL4 was significantly increased in alcohol-exposed animals compared to SI as well. Alcohols 18-25 interleukin 1 beta Rattus norvegicus 100-108 27012613-8 2016 After 5z-7-oxozeaenol treatment in epileptic rats, TRAF6-TAK1-P-TAK1 signaling protein expressions were reduced, inflammatory cytokine IL-1beta expression was decreased, neuron survival index was improved, the neuron apoptosis index was decreased and seizure durations were alleviated. 5-7-oxo-zeaenol 6-21 interleukin 1 beta Rattus norvegicus 135-143 27363651-6 2016 In addition, NG significantly inhibited the increase of cardiac expression of IL-1beta, IL-6, and interferon gamma. naringenin 13-15 interleukin 1 beta Rattus norvegicus 78-86 27247388-4 2016 Using pharmacologic and genetic approaches, we discovered that the initiation and maintenance of this multimonth prolongation of neuropathic pain was mediated by a previously unidentified mechanism for spinal cord and pain-namely, morphine-induced spinal NOD-like receptor protein 3 (NLRP3) inflammasomes and associated release of interleukin-1beta (IL-1beta). Morphine 231-239 interleukin 1 beta Rattus norvegicus 331-348 27247388-4 2016 Using pharmacologic and genetic approaches, we discovered that the initiation and maintenance of this multimonth prolongation of neuropathic pain was mediated by a previously unidentified mechanism for spinal cord and pain-namely, morphine-induced spinal NOD-like receptor protein 3 (NLRP3) inflammasomes and associated release of interleukin-1beta (IL-1beta). Morphine 231-239 interleukin 1 beta Rattus norvegicus 350-358 26996510-7 2016 Furthermore, both alcohol-exposed and SI animals had increased levels of pro-inflammatory cytokines IL-1beta, TNF-alpha, CD11b, and CCL4; in addition, CCL4 was significantly increased in alcohol-exposed animals compared to SI as well. Silicon 38-40 interleukin 1 beta Rattus norvegicus 100-108 26996510-7 2016 Furthermore, both alcohol-exposed and SI animals had increased levels of pro-inflammatory cytokines IL-1beta, TNF-alpha, CD11b, and CCL4; in addition, CCL4 was significantly increased in alcohol-exposed animals compared to SI as well. Alcohols 187-194 interleukin 1 beta Rattus norvegicus 100-108 27245224-3 2016 Here, we aimed to identify the cellular mechanisms by which high glucose exacerbates the vascular inflammation induced by IL1beta. Glucose 65-72 interleukin 1 beta Rattus norvegicus 122-129 27157092-11 2016 In IL-1beta-stimulated primary rat astrocytes, pretreatment with minocycline (75, 100 mumol/L) significantly inhibited the translocation of NF-kappaB to nucleus. Minocycline 65-76 interleukin 1 beta Rattus norvegicus 3-11 27284307-5 2016 Treatment of the 2VO rats with melatonin significantly reduced the escape latency and neuronal cell damage, and was associated with reduced levels of malondialdehyde, microglial activation, and tumor necrosis factor-alpha and interleukin-1beta in the ischemic hippocampus. Melatonin 31-40 interleukin 1 beta Rattus norvegicus 226-243 27338064-13 2016 Rosuvastatin treatment reduced the infiltration of inflammatory cells and TNF-alpha and IL-1beta expression. Rosuvastatin Calcium 0-12 interleukin 1 beta Rattus norvegicus 88-96 27064547-9 2016 In vivo assays revealed that resveratrol reduced levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and liver pathological changes, while it alleviated hepatocyte apoptosis, negatively mediated the production of TNF-alpha and IL-1beta in serum, and reversed TLR4/NF-kappaB signaling pathway caused by hepatic ischemia/reperfusion stimulation in liver tissues. Resveratrol 29-40 interleukin 1 beta Rattus norvegicus 254-262 27072679-8 2016 RESULTS: Ethyl pyruvate treatment inhibited microglia activation and reduced the expression of proinflammatory cytokines (IL-1beta and TNF-alpha). ethyl pyruvate 9-23 interleukin 1 beta Rattus norvegicus 122-130 27059924-6 2016 Whereas the treatment with 1400W had no impact on the elevated systolic blood pressure and leptin levels in glucose-fed rats, it significantly reversed or attenuated hyperglycaemia, hyperinsulinaemia, insulin resistance (HOMA index), body weight gain, peroxynitrite formation (nitrotyrosine expression) and the up-regulation of biomarkers of inflammation (B1 receptor, carboxypeptidase M, iNOS and IL-1beta) in renal cortex and aorta and to some extent in the liver. N-((3-(aminomethyl)phenyl)methyl)ethanimidamide 27-32 interleukin 1 beta Rattus norvegicus 398-406 27284355-5 2016 In addition, sitagliptin inhibited the increased protein expression of IL-6, TNF-alpha and IL-1beta. Sitagliptin Phosphate 13-24 interleukin 1 beta Rattus norvegicus 91-99 27313665-10 2016 Furthermore, the levels of MDA and inflammatory mediators (NF-kappaB, TNF-alpha and IL-1beta) were decreased in liver tissues, and the overexpression of CYP2E1 mRNA induced by ethanol treatment. Ethanol 176-183 interleukin 1 beta Rattus norvegicus 84-92 27245224-8 2016 RESULTS: We found that excess glucose uptake in HASMC cultured in 22 mM glucose only occurred following activation with IL1beta. Glucose 30-37 interleukin 1 beta Rattus norvegicus 120-127 27245224-8 2016 RESULTS: We found that excess glucose uptake in HASMC cultured in 22 mM glucose only occurred following activation with IL1beta. hasmc 48-53 interleukin 1 beta Rattus norvegicus 120-127 27245224-8 2016 RESULTS: We found that excess glucose uptake in HASMC cultured in 22 mM glucose only occurred following activation with IL1beta. Glucose 72-79 interleukin 1 beta Rattus norvegicus 120-127 27245224-10 2016 In fact, besides allowing glucose entry, IL1beta activated the PPP, thus permitting some of the excess glucose to be metabolized via this route. Glucose 103-110 interleukin 1 beta Rattus norvegicus 41-48 27245224-12 2016 Moreover, in rat mesenteric microvessels high glucose incubation enhanced the endothelial dysfunction induced by IL1beta by a mechanism which was abrogated by the inhibition of the PPP. Glucose 46-53 interleukin 1 beta Rattus norvegicus 113-120 27245224-13 2016 CONCLUSIONS: A pro-inflammatory stimulus like IL1beta transforms excess glucose into a vascular deleterious agent by causing an increase in glucose uptake and its subsequent diversion into the PPP, promoting the pro-oxidant conditions required for the exacerbation of pro-oxidant and pro-inflammatory pathways. Glucose 72-79 interleukin 1 beta Rattus norvegicus 46-53 27245224-13 2016 CONCLUSIONS: A pro-inflammatory stimulus like IL1beta transforms excess glucose into a vascular deleterious agent by causing an increase in glucose uptake and its subsequent diversion into the PPP, promoting the pro-oxidant conditions required for the exacerbation of pro-oxidant and pro-inflammatory pathways. Glucose 140-147 interleukin 1 beta Rattus norvegicus 46-53 27142746-4 2016 Cd intoxication revealed increased levels of proinflammatory cytokines (TNF-alpha, IL1beta and IFN-gamma), reduced levels of cellular defense proteins (Nrf-2 and HO-1) and glucose transporter (GLUT-2 and GLUT-4) along with the enhanced levels of signaling molecules of apoptosis (cleaved Caspase-12/9/8/3) in the pancreas of Cd-intoxicated rats. Cadmium 0-2 interleukin 1 beta Rattus norvegicus 83-90 27083000-7 2016 In the cultured visceral WAT, visfatin antagonist (FK-866) attenuated the LPS-induced up-regulations of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha). N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide 51-57 interleukin 1 beta Rattus norvegicus 132-140 27044804-5 2016 In the insulin-secreting INS-1 cells, arglabin inhibited, in a concentration-dependent manner, the maturation of pro-IL-1beta into biologically active IL-1beta probably through the inhibition of the maturation of procaspase-1 into active capsase-1. arglabin 38-46 interleukin 1 beta Rattus norvegicus 117-125 27044804-5 2016 In the insulin-secreting INS-1 cells, arglabin inhibited, in a concentration-dependent manner, the maturation of pro-IL-1beta into biologically active IL-1beta probably through the inhibition of the maturation of procaspase-1 into active capsase-1. arglabin 38-46 interleukin 1 beta Rattus norvegicus 151-159 27382377-9 2016 EC+PBS mixture reduced the production of PGE2, NO, IL-1beta, and IL-6. ec 0-2 interleukin 1 beta Rattus norvegicus 51-59 27382377-9 2016 EC+PBS mixture reduced the production of PGE2, NO, IL-1beta, and IL-6. bamboo salt 3-6 interleukin 1 beta Rattus norvegicus 51-59 26850876-8 2016 However, decreased synovial tissue inflammation and lower mRNA and protein levels of IL-1beta and MMP-3 were observed in the iOVD + SB203580 group. SB 203580 132-140 interleukin 1 beta Rattus norvegicus 85-93 26891162-12 2016 Furthermore, addition of GSNO reduced plasma and intestinal tumor necrosis factor and interleukin 1beta levels as well as inhibited the LPS-induced up-regulation of myosin light-chain kinase expression and NF-kappaB p65 level in the intestine. S-Nitrosoglutathione 25-29 interleukin 1 beta Rattus norvegicus 86-103 27109015-7 2016 Chronic ibuprofen treatment decreased urinary protein excretion, blood urea nitrogen, glomerular basement membrane thickening and renal fibrosis, which were accompanied by increases in PPARgamma protein expression, glutathione (GSH) level, and superoxide dismutase (SOD) activity, decreases in cyclooxygenase 2 and inducible nitric oxide synthase protein expressions, as well as a decreased interleukin 1beta (IL-1beta) level in the renal cortex of DN rats. Ibuprofen 8-17 interleukin 1 beta Rattus norvegicus 391-408 27109015-7 2016 Chronic ibuprofen treatment decreased urinary protein excretion, blood urea nitrogen, glomerular basement membrane thickening and renal fibrosis, which were accompanied by increases in PPARgamma protein expression, glutathione (GSH) level, and superoxide dismutase (SOD) activity, decreases in cyclooxygenase 2 and inducible nitric oxide synthase protein expressions, as well as a decreased interleukin 1beta (IL-1beta) level in the renal cortex of DN rats. Ibuprofen 8-17 interleukin 1 beta Rattus norvegicus 410-418 27109015-8 2016 Furthermore, the reduced IL-1beta level, increased GSH quantities and stronger SOD activity in the rat serum were evaluated in ibuprofen-treated diabetic rats and were compared with untreated diabetic rats. Ibuprofen 127-136 interleukin 1 beta Rattus norvegicus 25-33 27347312-6 2016 ISO treatment decreased the myeloperoxidase activity, F4/80-positive cells, and the mRNA expression of IL-1beta and IL-18 in the lung tissues of LPS-treated rats. Isoflurane 0-3 interleukin 1 beta Rattus norvegicus 103-111 26907800-11 2016 In addition, ozone therapy suppressed excessive activation of TLR4 and p-NF-kappaB P65 in the tubulointerstitium of adenine-induced CKD rats, accompanied by the reduction of inflammation-related cytokines including monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6). Adenine 116-123 interleukin 1 beta Rattus norvegicus 300-317 26907800-11 2016 In addition, ozone therapy suppressed excessive activation of TLR4 and p-NF-kappaB P65 in the tubulointerstitium of adenine-induced CKD rats, accompanied by the reduction of inflammation-related cytokines including monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6). Adenine 116-123 interleukin 1 beta Rattus norvegicus 319-327 27222637-0 2016 Erratum to: Interleukin-1beta-induced reduction of tissue water diffusion in the juvenile rat brain on ADC MRI is not associated with (31)P MRS-detectable energy failure. Water 58-63 interleukin 1 beta Rattus norvegicus 12-29 27184741-7 2016 RESULTS: Formalin injection caused acute and chronic inflammatory responses including transient local edema, increased levels of inflammatory cytokines, TNF-alpha, and IL-1beta in the blood as well as in the brain, and increased microglia in the brain. Formaldehyde 9-17 interleukin 1 beta Rattus norvegicus 168-176 27082007-7 2016 Treatment with tetrandrine reduced the expression levels of COX-2, IL-1beta, TNF-alpha, NF-kappaB, iNOS and caspase-3, and increased the Bcl-2 protein expression in sevoflurane-treated aged rats. tetrandrine 15-26 interleukin 1 beta Rattus norvegicus 67-75 27012773-7 2016 Following MAG-EPA administrations, tissue levels of the proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6 were markedly lower compared with rats treated only with DSS. 1-eicosapentaenoylglycerol 10-17 interleukin 1 beta Rattus norvegicus 93-101 27347328-7 2016 Administration of PTX significantly attenuated ALI induced by IAC, evidenced by reduced histological scores and wet lung contents, improved blood gas parameters, decreased cell counts and protein amounts in bronchoalveolar lavage fluids, and inhibition of MPO activity and ICAM-1 expression in lung tissues, and lower plasma levels of TNF-alpha, IL-6, IL-1beta and soluble ICAM-1. Pentoxifylline 18-21 interleukin 1 beta Rattus norvegicus 352-360 26999361-6 2016 Moreover, KA-induced microglia activation and gene expression of proinflammatory cytokines, namely, interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha, in the hippocampus were reduced by the lidocaine pretreatment. Lidocaine 206-215 interleukin 1 beta Rattus norvegicus 100-117 27177152-6 2016 D-Trp(8)-gammaMSH decreased LPS-induced anorexia and prevented the stimulatory effect of LPS on hypothalamic IL-1beta, COX-2 and CRH as well as on serum ACTH and corticosterone. D-Tryptophan 0-5 interleukin 1 beta Rattus norvegicus 109-117 27176485-13 2016 Both HA and PBS induced acute tendon injury and inflammation, sequential histopathological changes, ED1+ and ED2+ macrophage accumulation, IL-1beta expression, and neovascularization until post-injection day 42.HA induced more-severe injury than did PBS. pbs 12-15 interleukin 1 beta Rattus norvegicus 139-147 26946116-7 2016 These results showed exposure to AlCl3 lead to increased mRNA levels of IL-1beta, IL-6, TNF-alpha and MCH II, decreased mRNA levels of CX3CL1 and BDNF, decreased density of dendritic spine and impaired learning and memory in developing rat. Aluminum Chloride 33-38 interleukin 1 beta Rattus norvegicus 72-80 27168839-9 2016 Carvedilol was observed to significantly reduce clinical sign scores in a dose-dependent manner (P<0.01), and reduce IL-1beta, IL-6, IL-8 and TNF-alpha expression levels (P<0.01) in the LPS-induced rat model of conjunctivitis. Carvedilol 0-10 interleukin 1 beta Rattus norvegicus 120-128 27398410-6 2016 BEX supplement to the TG rats significantly lowered protein expressions of GFAP, p65, and c-Jun, and showed a trend to decrease the protein expression of IL-1beta. BEX 0-3 interleukin 1 beta Rattus norvegicus 154-162 26868031-7 2016 PBM increased the tissue levels of IL-1beta at the early stage of oral wound healing (p < 0.01) and increased the tissue levels of TNF-alpha during all stages of oral wound healing (p < 0.05). pbm 0-3 interleukin 1 beta Rattus norvegicus 35-43 26973056-9 2016 A pilocarpine re-injection resulted in less hippocampal neuronal apoptosis and reduced level of interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and microglial activation in epileptic rats with TNS treatment in comparison to the epileptic rats without TNS treatment. Pilocarpine 2-13 interleukin 1 beta Rattus norvegicus 96-114 26973056-9 2016 A pilocarpine re-injection resulted in less hippocampal neuronal apoptosis and reduced level of interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and microglial activation in epileptic rats with TNS treatment in comparison to the epileptic rats without TNS treatment. Pilocarpine 2-13 interleukin 1 beta Rattus norvegicus 116-124 26798045-5 2016 We observed significant elevation (p < 0.05) in serum IL-1beta correlating with hemorrhages and leucocytic and lymphocytic infiltration in the liver and intestines as evidences of an acute inflammatory response to AFB1 administration. Aflatoxin B1 217-221 interleukin 1 beta Rattus norvegicus 57-65 27040098-9 2016 Furthermore resveratrol attenuated the protein levels of TNFalpha and IL1beta in the 24-month group. Resveratrol 12-23 interleukin 1 beta Rattus norvegicus 70-77 26143258-5 2016 Minocycline treatment markedly attenuated brain edema secondary to blood-brain barrier (BBB) dysfunction by inhibiting NLRP3 inflammasome activation, which controls the maturation and release of pro-inflammatory cytokines, especially interleukin-1beta (IL-1beta). Minocycline 0-11 interleukin 1 beta Rattus norvegicus 234-251 26143258-5 2016 Minocycline treatment markedly attenuated brain edema secondary to blood-brain barrier (BBB) dysfunction by inhibiting NLRP3 inflammasome activation, which controls the maturation and release of pro-inflammatory cytokines, especially interleukin-1beta (IL-1beta). Minocycline 0-11 interleukin 1 beta Rattus norvegicus 253-261 27095151-15 2016 Furthermore, physostigmine reduced IL1beta (p < 0.05). Physostigmine 13-26 interleukin 1 beta Rattus norvegicus 35-42 27063892-9 2016 In cultured endothelial cells Ni(PipNONO)Cl restored the cell functions (cytoskeletal protein expression, migration and proliferation) altered by the inflammatory mediator interleukin-1beta (IL-1beta), impairing the endothelial to mesenchimal transition. ni(pipnono)cl 30-43 interleukin 1 beta Rattus norvegicus 172-189 27228525-2 2016 Pentoxifylline inhibits the production of inflammatory cytokines including tumor necrosis factor alpha(TNF- alpha) and interleukin 1beta (IL-1beta). Pentoxifylline 0-14 interleukin 1 beta Rattus norvegicus 119-136 27228525-2 2016 Pentoxifylline inhibits the production of inflammatory cytokines including tumor necrosis factor alpha(TNF- alpha) and interleukin 1beta (IL-1beta). Pentoxifylline 0-14 interleukin 1 beta Rattus norvegicus 138-146 27228525-12 2016 Pentoxifylline decreased the paclitaxel-induced TNF- alpha and IL-1beta levels. Pentoxifylline 0-14 interleukin 1 beta Rattus norvegicus 63-71 27228525-12 2016 Pentoxifylline decreased the paclitaxel-induced TNF- alpha and IL-1beta levels. Paclitaxel 29-39 interleukin 1 beta Rattus norvegicus 63-71 27228525-13 2016 In addition, IL-1beta was expressed in neurons and satellite cells in the lumbar dorsal root ganglia after paclitaxel. Paclitaxel 107-117 interleukin 1 beta Rattus norvegicus 13-21 27063892-9 2016 In cultured endothelial cells Ni(PipNONO)Cl restored the cell functions (cytoskeletal protein expression, migration and proliferation) altered by the inflammatory mediator interleukin-1beta (IL-1beta), impairing the endothelial to mesenchimal transition. ni(pipnono)cl 30-43 interleukin 1 beta Rattus norvegicus 191-199 26359686-8 2016 RESULTS: Mtx administration increased histopathological damage and increased TNF-alpha, IL-1beta, TOS, TAC, and OSI levels in the small intestine tissues. Methotrexate 9-12 interleukin 1 beta Rattus norvegicus 88-96 26359686-9 2016 Lyc therapy applied to the Mtx-L group provided significant improvement in all parameters of histopathological damage to the small intestine and significantly reduced the levels of IL-1beta, TOS, and OSI in the intestinal tissues. Methotrexate 27-30 interleukin 1 beta Rattus norvegicus 181-189 26359686-9 2016 Lyc therapy applied to the Mtx-L group provided significant improvement in all parameters of histopathological damage to the small intestine and significantly reduced the levels of IL-1beta, TOS, and OSI in the intestinal tissues. l 0-1 interleukin 1 beta Rattus norvegicus 181-189 24215062-6 2016 Besides, TCDD led to significant histopathological damage in liver and serum cytokine levels alterations (increase in tumor necrosis factor alpha and interleukin 1beta levels). Polychlorinated Dibenzodioxins 9-13 interleukin 1 beta Rattus norvegicus 150-167 27116554-5 2016 Treatment with HPMC/GSNO 10 mM solution significantly reduced alveolar bone loss, oxidative stress and TNF-alpha e IL-1beta levels in the surrounding gingival tissue, and led to a decreased transcription of RANK and TNF-alpha genes and elevated bone alkaline phosphatase, compared to the HPMC group. Hypromellose Derivatives 15-19 interleukin 1 beta Rattus norvegicus 115-123 27188737-10 2016 Markedly, the level of the whole brain IL-1beta was found to be significantly higher in the ketamine treated group in comparison to the control group rats. Ketamine 92-100 interleukin 1 beta Rattus norvegicus 39-47 26953552-8 2016 Similar to the protective effect of USP22 knockdown, resveratrol (RSV) depressed not only high d-glucose- and USP22 overexpression-induced cytotoxicity, but also the secretion of TNF-alpha, IL-1beta, IL-6 and TGF-beta1. Resveratrol 53-64 interleukin 1 beta Rattus norvegicus 190-198 26953552-8 2016 Similar to the protective effect of USP22 knockdown, resveratrol (RSV) depressed not only high d-glucose- and USP22 overexpression-induced cytotoxicity, but also the secretion of TNF-alpha, IL-1beta, IL-6 and TGF-beta1. Resveratrol 66-69 interleukin 1 beta Rattus norvegicus 190-198 27383488-9 2016 After applying DFA, the concentration of iron ions in the brain tissue around the hematoma was significantly reduced, so did the number of microglial cells and activation of neurotoxic cytokines (IL-1beta and TNF-alpha content) secreted by microglial cells was significantly reduced. Diphenylamine 15-18 interleukin 1 beta Rattus norvegicus 196-204 27116554-5 2016 Treatment with HPMC/GSNO 10 mM solution significantly reduced alveolar bone loss, oxidative stress and TNF-alpha e IL-1beta levels in the surrounding gingival tissue, and led to a decreased transcription of RANK and TNF-alpha genes and elevated bone alkaline phosphatase, compared to the HPMC group. S-Nitrosoglutathione 20-24 interleukin 1 beta Rattus norvegicus 115-123 27108411-1 2016 BACKGROUND 17beta-Estradiol (E2) has been reported to protect annulus fibrosus (AF) cells in vitro against interleukin-1beta (IL-1beta)-induced apoptosis in a concentration-dependent manner. Estradiol 11-27 interleukin 1 beta Rattus norvegicus 107-124 27090509-12 2016 Sulforaphane promotes polarization of microglia from the M1 to the M2 phenotype, reducing IL-1b and increasing IL-4, IL-10, Arg1, and YM-1 in the cerebellum. sulforaphane 0-12 interleukin 1 beta Rattus norvegicus 90-95 27108411-1 2016 BACKGROUND 17beta-Estradiol (E2) has been reported to protect annulus fibrosus (AF) cells in vitro against interleukin-1beta (IL-1beta)-induced apoptosis in a concentration-dependent manner. Estradiol 11-27 interleukin 1 beta Rattus norvegicus 126-134 27120616-10 2016 Additionally, gene expression of pro-inflammatory cytokines, including IL-1beta, IL-6, and TNF-alpha, and the protein levels of NF-kappaB and iNOS were significantly increased in brain tissues of DOX-treated group, whereas omega-3 PUFAs supplementation significantly attenuated DOX-induced neuroinflammation. Doxorubicin 196-199 interleukin 1 beta Rattus norvegicus 71-79 26463212-6 2016 The upregulated production of IL-1beta, IL-6 and IL-10 and downregulated that of TGF-beta was observed in response to LPS in resident and thioglycollate-elicited macrophages from rats of both ages. Thioglycolates 138-152 interleukin 1 beta Rattus norvegicus 30-38 27108901-9 2016 In the hypoxia-treated rats, minocycline down-regulated Iba-1, IL-1beta, TNF-alpha and EAAT2 protein expressions significantly, but did not affect total Tau and phosphorylated Tau protein expressions. Minocycline 29-40 interleukin 1 beta Rattus norvegicus 63-71 26884383-7 2016 Inhibition of neutral sphingomyelinase, a key player in the IL-1beta signaling cascade that acts upstream of ERK, also suppressed the IL-1beta effects, while increasing the ceramide, through the addition of C2-ceramide or via treatment with exogenous sphingomyelinase, was sufficient to induce IGFBP1 promoter-driven luciferase activity. Ceramides 173-181 interleukin 1 beta Rattus norvegicus 60-68 26884383-7 2016 Inhibition of neutral sphingomyelinase, a key player in the IL-1beta signaling cascade that acts upstream of ERK, also suppressed the IL-1beta effects, while increasing the ceramide, through the addition of C2-ceramide or via treatment with exogenous sphingomyelinase, was sufficient to induce IGFBP1 promoter-driven luciferase activity. N-acetylsphingosine 207-218 interleukin 1 beta Rattus norvegicus 60-68 26884383-7 2016 Inhibition of neutral sphingomyelinase, a key player in the IL-1beta signaling cascade that acts upstream of ERK, also suppressed the IL-1beta effects, while increasing the ceramide, through the addition of C2-ceramide or via treatment with exogenous sphingomyelinase, was sufficient to induce IGFBP1 promoter-driven luciferase activity. N-acetylsphingosine 207-218 interleukin 1 beta Rattus norvegicus 134-142 27143890-10 2016 Both IL-1beta and IL-6 were downregulated by SJF and fluoxetine. sjf 45-48 interleukin 1 beta Rattus norvegicus 5-13 27143890-10 2016 Both IL-1beta and IL-6 were downregulated by SJF and fluoxetine. Fluoxetine 53-63 interleukin 1 beta Rattus norvegicus 5-13 27143890-14 2016 CONCLUSION: Dysfunction of proinflammatory cytokines and Tregs in different stages of PPD was attenuated by SJF and fluoxetine through the modulation of serum concentrations of IL-1beta and IL-6, expressions of IL-1RI, and gp130 in the hippocampus, and CD4(+)CD25(+) Treg cells in peripheral blood. Fluoxetine 116-126 interleukin 1 beta Rattus norvegicus 177-185 27073627-5 2016 The results suggest that the IL-1beta-induced BTB permeability increase may be associated with the expression of caveolin-1 protein, and VEGF may be involved in this process. btb 46-49 interleukin 1 beta Rattus norvegicus 29-37 27044820-7 2016 RESULTS: CS-GlcN protected against cartilage degradation and reduced the levels of inflammatory mediators such as interleukin-1beta and tumor necrosis factor-alpha in the affected knee. Cesium 9-11 interleukin 1 beta Rattus norvegicus 114-163 27044820-7 2016 RESULTS: CS-GlcN protected against cartilage degradation and reduced the levels of inflammatory mediators such as interleukin-1beta and tumor necrosis factor-alpha in the affected knee. Glucosamine 12-16 interleukin 1 beta Rattus norvegicus 114-163 26937856-0 2016 Desipramine administered chronically inhibits lipopolysaccharide-stimulated production of IL-1beta in the brain and plasma of rats. Desipramine 0-11 interleukin 1 beta Rattus norvegicus 90-98 26905582-9 2016 RS-containing diets increased short chain fatty acids (SCFA) and expression of the SCFA receptor GPR43 mRNA, and reduced inflammation (COX-2, NF-kB, TNF-alpha and IL-1beta mRNA) and cell proliferation P< 0.05. rs 0-2 interleukin 1 beta Rattus norvegicus 163-171 26937856-2 2016 The present study investigated for the first time the effect of 21-day oral administration of desipramine on the lipopolysaccharide (LPS)-stimulated IL-1beta concentration in the olfactory bulb, hypothalamus, frontal cortex, hippocampus and plasma of rats, and on the LPS-induced IL-1beta mRNA level in the olfactory bulb. Desipramine 94-105 interleukin 1 beta Rattus norvegicus 149-157 26937856-2 2016 The present study investigated for the first time the effect of 21-day oral administration of desipramine on the lipopolysaccharide (LPS)-stimulated IL-1beta concentration in the olfactory bulb, hypothalamus, frontal cortex, hippocampus and plasma of rats, and on the LPS-induced IL-1beta mRNA level in the olfactory bulb. Desipramine 94-105 interleukin 1 beta Rattus norvegicus 280-288 26937856-6 2016 By using the alpha1/alpha2-adrenoceptor antagonist prazosin and the unspecific beta-adrenoceptor antagonist propranolol given prior to LPS, we found that the effect of desipramine on LPS-induced IL-1beta production was partially mediated by both adrenoceptors in the olfactory bulb and plasma, and that beta-adrenoceptors contributed also to its effect on the stimulated IL-1beta concentration in the hypothalamus. Desipramine 168-179 interleukin 1 beta Rattus norvegicus 195-203 27279986-11 2016 Moreover, naringin supplement dramatically increased SOD levels, reduced MDA levels, and alleviated TNF-alpha, IL-1beta, and IL-6 compared with the STZ group in the hippocampus. naringin 10-18 interleukin 1 beta Rattus norvegicus 111-119 27279977-10 2016 CONCLUSION: The results showed that DIO causes overexpression of IL-1beta, IRAK-1 and TRAF-6 mRNA in an experimental model of asthma. 3,3'-Dioctadecyloxacarbocyanine perchlorate 36-39 interleukin 1 beta Rattus norvegicus 65-73 26946964-7 2016 Altogether, these results suggest that delirium rats induced by scopolamine may be correlated with an increased cerebral concentration of 5-HT and dopamine neurotransmitters system; the selective 5-HT(1A) antagoniszts can reverse the delirium symptoms at some extent through tendering PI3K/Akt/mammalian target of rapamycin complex 1 (mTOR) activation-induced NLRP3 activity and then reducing IL-1beta release. Scopolamine 64-75 interleukin 1 beta Rattus norvegicus 393-401 27092634-4 2016 Moreover, during endosulfan-induced neuronal cell death, mRNA expression of pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was elevated, which seemed to be mediated by the activation of nuclear factor-kappa B (NF-kappaB) by phosphorylation of p65 subunit. Endosulfan 17-27 interleukin 1 beta Rattus norvegicus 156-173 27054520-14 2016 Dexamethasone-PUD downregulated proinflammatory cytokines/chemokines (IL-1beta, IL-6, cytokine-induced neutrophil chemoattractant [CINC]) and inducible nitric oxide synthase (iNOS) and upregulated IL-10 anti-inflammatory cytokine. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 70-78 26955884-6 2016 The current study demonstrated that glycyrrhizic acid could alleviate MTX-induced increases of tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 levels, and raise IL-10 levels, in rats with enteritis. Glycyrrhizic Acid 36-53 interleukin 1 beta Rattus norvegicus 124-146 26955884-6 2016 The current study demonstrated that glycyrrhizic acid could alleviate MTX-induced increases of tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 levels, and raise IL-10 levels, in rats with enteritis. Methotrexate 70-73 interleukin 1 beta Rattus norvegicus 124-146 28879744-10 2016 These results indicated that Abeta1-42 could induce RA-h activation and its release of IL-1beta, TNF-alpha and other inflammatory factors to aggravate the PC12 cells injury; beta-asarone could reduce the levels of IL-1beta, TNF-alpha, promote the release of BDNF, and inhibit the NF-kappaB activity as well as phosphorylation levels of ERK, p38 and JNK protein in PC12 cells. asarone 174-186 interleukin 1 beta Rattus norvegicus 214-222 28884529-4 2016 The concentration of TNF-alpha and IL-1beta of rat pleural effusion in GML, CMM and WMM group decreased significantly. dodecanoic acid;propane-1,2,3-triol 71-74 interleukin 1 beta Rattus norvegicus 35-43 25966322-4 2016 AMME-treated rats had lower expression levels of nitric oxide, tumor necrosis factor-alpha, interleukins (IL-1beta, IL-6 and IL-12) and titer of anti-type II collagen antibody compared with untreated CIA rats. amme 0-4 interleukin 1 beta Rattus norvegicus 106-114 25663200-8 2016 Administration of sEH inhibitor AUDA significantly suppressed local inflammatory responses as indicated by the reduced microglia activation and IL-1 beta expression, as well as the decreased infiltration of neutrophils and T lymphocytes. 12-(3-adamantan-1-ylureido)dodecanoic acid 32-36 interleukin 1 beta Rattus norvegicus 144-153 26690894-6 2016 The contents of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6) in hippocampus and serum were significantly reduced with salidroside (20 mg/kg, 40 mg/kg) treatment compared with those in the CIA group. rhodioloside 196-207 interleukin 1 beta Rattus norvegicus 84-102 26690894-6 2016 The contents of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6) in hippocampus and serum were significantly reduced with salidroside (20 mg/kg, 40 mg/kg) treatment compared with those in the CIA group. rhodioloside 196-207 interleukin 1 beta Rattus norvegicus 104-112 27212924-5 2016 At 3 days, animals in the high-dose CG group had smaller infarct volumes, greater interleukin-10 expression, and fewer interleukin-1beta-immunoreactive cells than those in the untreated model group. cg 36-38 interleukin 1 beta Rattus norvegicus 119-136 28879744-8 2016 Results showed that beta-asarone (55.5 mg L-1) could significantly slowdown the decline of PC12 cells survival rate caused by Abeta1-42-induced RA-h activation (P<0.01), significantly reduce the levels of IL-1beta, TNF-alpha and the phosphorylation levels of ERK, p38 and JNK in culture media of the lower chamber (P<0.01). asarone 20-32 interleukin 1 beta Rattus norvegicus 208-216 27043583-6 2016 Fucoxanthin treatment resulted in a slight decrease in tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 levels and a significant decrease in oxidative stress index. fucoxanthin 0-11 interleukin 1 beta Rattus norvegicus 84-101 27127723-7 2016 RESULTS: We found that estradiol reduced the level of proinflammatory cytokines including IL-1beta and TNF-alpha, both in vivo and in vitro. Estradiol 23-32 interleukin 1 beta Rattus norvegicus 90-98 26989349-0 2016 Interleukin-1beta-induced reduction of tissue water diffusion in the juvenile rat brain on ADC MRI is not associated with (31)P MRS-detectable energy failure. Water 46-51 interleukin 1 beta Rattus norvegicus 0-17 26989349-1 2016 BACKGROUND: It has long been known that an intrastriatal microinjection of the archetypal pro-inflammatory cytokine, interleukin-1beta (IL-1beta), in juvenile rats induces a chronic reduction in the apparent diffusion coefficient (ADC) of tissue water on magnetic resonance imaging (MRI). Water 246-251 interleukin 1 beta Rattus norvegicus 117-134 26989349-1 2016 BACKGROUND: It has long been known that an intrastriatal microinjection of the archetypal pro-inflammatory cytokine, interleukin-1beta (IL-1beta), in juvenile rats induces a chronic reduction in the apparent diffusion coefficient (ADC) of tissue water on magnetic resonance imaging (MRI). Water 246-251 interleukin 1 beta Rattus norvegicus 136-144 26599792-6 2016 The selective P2X7R antagonist A-438079 was used to examine the P2X7R+ microglia-dependent release of IL-1beta and IL-18. 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine 31-39 interleukin 1 beta Rattus norvegicus 102-110 26599792-9 2016 Moreover, A-438079 also improved pain thresholds and suppressed overexpression of IL-1beta in the CCI- and BzATP-injected rats. CCI 98-101 interleukin 1 beta Rattus norvegicus 82-90 26599792-9 2016 Moreover, A-438079 also improved pain thresholds and suppressed overexpression of IL-1beta in the CCI- and BzATP-injected rats. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 107-112 interleukin 1 beta Rattus norvegicus 82-90 26599792-10 2016 The analysis of cultured microglia further demonstrated that A-438079 markedly decreased BzATP-induced IL-1beta release. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 89-94 interleukin 1 beta Rattus norvegicus 103-111 27092634-4 2016 Moreover, during endosulfan-induced neuronal cell death, mRNA expression of pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was elevated, which seemed to be mediated by the activation of nuclear factor-kappa B (NF-kappaB) by phosphorylation of p65 subunit. Endosulfan 17-27 interleukin 1 beta Rattus norvegicus 175-183 26851531-7 2016 KEY FINDINGS: In the joint homogenate of rats with MSU crystal-induced inflammation, treatment with ferulic acid (30mg/kg body weight (b.wt)) decreased paw edema; the level/activity of elastase, lysosomal enzymes, nitric oxide, lipid peroxidation, and pro-inflammatory cytokines (TNF-alpha and IL-1beta); and the mRNA expression of NLRP3 inflammasomes, caspase-1, pro-inflammatory cytokines, and NF-kappaB p65. ferulic acid 100-112 interleukin 1 beta Rattus norvegicus 294-302 25893720-5 2016 RESULTS: LPS/GalN challenge alone resulted in significantly increased production of endotoxin, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and nitric oxide as compared to the normal control rats. Galactosamine 13-17 interleukin 1 beta Rattus norvegicus 136-154 25893720-5 2016 RESULTS: LPS/GalN challenge alone resulted in significantly increased production of endotoxin, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and nitric oxide as compared to the normal control rats. Galactosamine 13-17 interleukin 1 beta Rattus norvegicus 156-164 26751764-8 2016 Chronic treatment with mangiferin decreased the levels of myocardial enzymes (CK-MB, LDH) and inflammatory mediators (TNF-alpha, IL-1beta). mangiferin 23-33 interleukin 1 beta Rattus norvegicus 129-137 26550949-10 2016 The combination of ELISA and Western blot results showed that glycyrrhizin attenuated isoflurane-induced increases of pro-inflammatory cytokines (TNF-alpha and IL-1beta) and activation of HMGB1/NFkappaB signaling pathway in the hippocampus of neonatal rats. Glycyrrhizic Acid 62-74 interleukin 1 beta Rattus norvegicus 160-168 26550949-10 2016 The combination of ELISA and Western blot results showed that glycyrrhizin attenuated isoflurane-induced increases of pro-inflammatory cytokines (TNF-alpha and IL-1beta) and activation of HMGB1/NFkappaB signaling pathway in the hippocampus of neonatal rats. Isoflurane 86-96 interleukin 1 beta Rattus norvegicus 160-168 26718602-8 2016 Both markers were elevated in vitro and in vivo, and DEX and Ara-C were able to reduce IL-1beta and TGF-beta1 production. Dexamethasone 53-56 interleukin 1 beta Rattus norvegicus 87-95 26718602-8 2016 Both markers were elevated in vitro and in vivo, and DEX and Ara-C were able to reduce IL-1beta and TGF-beta1 production. Cytarabine 61-66 interleukin 1 beta Rattus norvegicus 87-95 26656865-7 2016 The decrease in hippocampal GR expression and increase in hippocampal IL-1beta and TNF-alpha accumulation could be prevented by hippocampal local infusion of minocycline, a microglial inhibitor. Minocycline 158-169 interleukin 1 beta Rattus norvegicus 70-78 26875558-8 2016 Finally, any one of the three drugs, diazepam, Ro5-4864 and pregnenolone, could reduce the activation of astrocytes and the production of interleukin-1beta (IL-1beta) in the L5 spinal dorsal horn 14 d after L5 SNL. Diazepam 37-45 interleukin 1 beta Rattus norvegicus 138-155 27127485-8 2016 Western blot assay showed that interleukin-1beta expression, and phosphorylation of the N-methyl-D-aspartate 2B receptor at tyrosine 1472, were lower in model rats that received tetrandrine than in those that did not. tetrandrine 178-189 interleukin 1 beta Rattus norvegicus 31-48 27127485-9 2016 The present findings suggest that tetrandrine may be neuroprotective in chronic vascular dementia by reducing interleukin-1beta expression, N-methyl-D-aspartate receptor 2B phosphorylation at tyrosine 1472, and neuronal necrosis. tetrandrine 34-45 interleukin 1 beta Rattus norvegicus 110-127 26873426-8 2016 RESULTS: Quercetin intervention reduced plasma amylase level (P < 0.001) in a dose-dependent manner, attenuated pancreatic histopathological damage (P < 0.05), and reduced the mRNA and protein expression of NF-kB, IL-1beta, IL-6, TNFalpha (P < 0.05) more significantly in HTG-related AP rats than in normal-lipid AP rats. Quercetin 9-18 interleukin 1 beta Rattus norvegicus 220-228 26875558-8 2016 Finally, any one of the three drugs, diazepam, Ro5-4864 and pregnenolone, could reduce the activation of astrocytes and the production of interleukin-1beta (IL-1beta) in the L5 spinal dorsal horn 14 d after L5 SNL. Diazepam 37-45 interleukin 1 beta Rattus norvegicus 157-165 26875558-8 2016 Finally, any one of the three drugs, diazepam, Ro5-4864 and pregnenolone, could reduce the activation of astrocytes and the production of interleukin-1beta (IL-1beta) in the L5 spinal dorsal horn 14 d after L5 SNL. 4'-chlorodiazepam 47-55 interleukin 1 beta Rattus norvegicus 138-155 26875558-8 2016 Finally, any one of the three drugs, diazepam, Ro5-4864 and pregnenolone, could reduce the activation of astrocytes and the production of interleukin-1beta (IL-1beta) in the L5 spinal dorsal horn 14 d after L5 SNL. 4'-chlorodiazepam 47-55 interleukin 1 beta Rattus norvegicus 157-165 30263277-6 2016 BF-RBEE also inhibited acetic acid-mediated increases in mRNA levels of nitric oxide synthase, interleukin-1beta, and tumor necrosis factor-alpha. Acetic Acid 23-34 interleukin 1 beta Rattus norvegicus 95-112 26875558-8 2016 Finally, any one of the three drugs, diazepam, Ro5-4864 and pregnenolone, could reduce the activation of astrocytes and the production of interleukin-1beta (IL-1beta) in the L5 spinal dorsal horn 14 d after L5 SNL. Pregnenolone 60-72 interleukin 1 beta Rattus norvegicus 138-155 26875558-8 2016 Finally, any one of the three drugs, diazepam, Ro5-4864 and pregnenolone, could reduce the activation of astrocytes and the production of interleukin-1beta (IL-1beta) in the L5 spinal dorsal horn 14 d after L5 SNL. Pregnenolone 60-72 interleukin 1 beta Rattus norvegicus 157-165 26711852-11 2016 In addition, methane significantly increased the superoxide dismutase (SOD) activity, lowered the CO-increased level of malondialdehyde (MDA) 3-nitrotyrosine (3-NT) and 8-hydroxy-2-deoxyguanosine (8-OHdG), inhibited levels of tumour necrosis factor-alpha (TNF-alpha), interleukin 1-beta (IL1-beta) and caspase-3 in the rat cerebral cortex and hippocampus but had no effect on IL-6 levels. Methane 13-20 interleukin 1 beta Rattus norvegicus 268-286 26901193-7 2016 Moreover, matrix metalloproteinase (MMP)-13 and COX-2 expressions of interleukin (IL)-1beta-stimulated primary rat chondrocytes were inhibited by zerumbone. zerumbone 146-155 interleukin 1 beta Rattus norvegicus 69-91 26891124-9 2016 Treatment with CARV 5 mg/kg also reduced expression levels of COX-2, RANK, RANKL, IBA-1, and ICAM-1 (all p < 0.05), while increasing expression of SOCS1, SOD-1, and GPx-1 (all p < 0.05) and decreasing expression of IL-1beta and NF-kappaB (both, p < 0.05). Carvedilol 15-19 interleukin 1 beta Rattus norvegicus 221-229 26721217-10 2016 The administration of RWE at dose of 100mg/kg also suppressed the TNBS- or DSS-stimulated expression of TNF-alpha, IL-1beta, monocyte chemotactic protein-1, inducible nitric oxide, and intercellular adhesion molecule-1. dss 75-78 interleukin 1 beta Rattus norvegicus 115-123 26786697-5 2016 In addition, TMP decreased the expression of several proinflammatory cytokines, including IL-1beta, TNFalpha and IL-18, reduced TUNEL-positive cells and caspase 3 and 9 activities, decreased thiobarbituric acid reactive substances content and increased glutathione level and superoxide dismutase activity in rats. tetramethylpyrazine 13-16 interleukin 1 beta Rattus norvegicus 90-98 27158345-8 2016 The serum level of inflammatory cytokines, such as TNF-alpha, IL-1beta, IFN-gamma and IL-6 were markedly decreased in colitis rats treated with STEA. stea 144-148 interleukin 1 beta Rattus norvegicus 62-70 26633263-7 2016 Moreover, rosuvastatin markedly inhibited microglial activation in LPS-challenged cells by affecting both their morphology and functions as it inhibited LPS-elicited phagocytosis and inhibited pro-inflammatory cytokine (IL-1beta, TNF-alpha) production, concomitantly increasing the level of IL-10, an anti-inflammatory cytokine. Rosuvastatin Calcium 10-22 interleukin 1 beta Rattus norvegicus 220-228 26711852-11 2016 In addition, methane significantly increased the superoxide dismutase (SOD) activity, lowered the CO-increased level of malondialdehyde (MDA) 3-nitrotyrosine (3-NT) and 8-hydroxy-2-deoxyguanosine (8-OHdG), inhibited levels of tumour necrosis factor-alpha (TNF-alpha), interleukin 1-beta (IL1-beta) and caspase-3 in the rat cerebral cortex and hippocampus but had no effect on IL-6 levels. Methane 13-20 interleukin 1 beta Rattus norvegicus 288-296 26959620-7 2016 RESULTS: Intraperitoneal ozone administration reversed TNF-alpha, IL-1beta, MDA and MPO levels and the colonic burst pressures. Ozone 25-30 interleukin 1 beta Rattus norvegicus 66-74 26403426-11 2016 RESULTS: Pretreatment with simvastatin prevented alendronate-induced macroscopic gastric damage and reduced the levels of MDA and GSH, TNF-alpha and IL-1beta, MPO activity, and mucus levels, in the stomach. Simvastatin 27-38 interleukin 1 beta Rattus norvegicus 149-157 26667466-3 2016 Zingerone treatment attenuated CCl4-induced increases in inflammatory mediators, including tumor necrosis factor-alpha, interleukin-1beta, cyclooxygenase-2, and inducible nitric oxide synthase mRNA levels. zingerone 0-9 interleukin 1 beta Rattus norvegicus 120-137 26667466-3 2016 Zingerone treatment attenuated CCl4-induced increases in inflammatory mediators, including tumor necrosis factor-alpha, interleukin-1beta, cyclooxygenase-2, and inducible nitric oxide synthase mRNA levels. Carbon Tetrachloride 31-35 interleukin 1 beta Rattus norvegicus 120-137 26705611-10 2016 Moreover, H2 treatment significantly decreased the number of 4-HNE-stained cells in the ganglion cell layer and inhibited the retinal overexpression of IL1-beta and TNF-alpha that was induced by retinal I/R injury. Hydrogen 10-12 interleukin 1 beta Rattus norvegicus 152-160 26996110-8 2016 Our results indicated that the expression levels of IL-1beta, IL-17A, NLRP3 and HMGB1 were elevated in the inflamed colon of rats with oxazolone-induced colitis. Oxazolone 135-144 interleukin 1 beta Rattus norvegicus 52-60 26893662-8 2016 Furthermore, paeoniflorin attenuated the activity of nuclear factor-kappaB p65 unit, tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6, and reduced the COX-2 protein expression level. peoniflorin 13-25 interleukin 1 beta Rattus norvegicus 114-136 27066297-8 2016 RESULTS: Injection of LPS stimulated inflammasome activation (caspase-1 activity) and the release of IL-1beta into the urine which was prevented by glyburide. Glyburide 148-157 interleukin 1 beta Rattus norvegicus 101-109 25852135-6 2016 L-Theanine prevented increased expression of NF-kappaB and down-regulated the pro-inflammatory (interleukin (IL)-1beta and IL-6) and profibrotic (TGF-beta and CTGF) cytokines. theanine 0-10 interleukin 1 beta Rattus norvegicus 96-118 26490364-6 2016 Silencing of ER-beta attenuated 17beta-estradiol mediated decrease in caspase 1, ASC, and IL-1beta. Estradiol 32-48 interleukin 1 beta Rattus norvegicus 90-98 26506502-8 2016 Monoiodoacetate increased the expression of matrix metalloprotinase-3 and metalloprotinase-13 in the articular cartilage and elevated the production of inflammatory markers such as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6, but they were lower in the UCE than in the other groups (P < 0.05). Iodoacetic Acid 0-15 interleukin 1 beta Rattus norvegicus 210-227 26373954-9 2016 RESULTS: The BTZ treatment induced an upsurge in the mRNA and protein levels of TNF-alpha in the neurons and IL-1beta in the astrocytes in the spinal dorsal horn. Bortezomib 13-16 interleukin 1 beta Rattus norvegicus 109-117 26373954-11 2016 Inhibition of TNF-alpha or IL-1beta ameliorated JNK activation and mechanical allodynia induced by BTZ. Bortezomib 99-102 interleukin 1 beta Rattus norvegicus 27-35 26373954-13 2016 CONCLUSION: Our results suggest that the TNF-alpha or IL-1beta/JNK pathway in the spinal dorsal horn may play a critical role in the development of painful peripheral neuropathy induced by BTZ. Bortezomib 189-192 interleukin 1 beta Rattus norvegicus 54-62 26946622-1 2016 OBJECTIVE: To evaluate the effect of Nelumbo Nucifera leaf water extract (NNLE) on insulinoma (RIN) cells induced by interleukin-1beta (IL-1beta) and interferon-g (IFN-gamma), and injured pancreatic beta-cells induced by Streptozotocin (STZ) in rats. leaf water 54-64 interleukin 1 beta Rattus norvegicus 117-134 26879793-1 2016 OBJECTIVE: To investigate the roles of PI3K in bone cancer pain, the present study was performed to demonstrate the changes of pain-related behavior and the production of IL-1beta, IL-6 and TNF-alpha after intrathecal injection of wortmannin (antagonist of PI3K receptors) in rat model. Wortmannin 231-241 interleukin 1 beta Rattus norvegicus 171-179 26820153-5 2016 RESULTS: In cirrhotic rats, high tumor necrosis factor (TNF)alpha, vascular endothelial growth factor (VEGF) and nitric oxide (NO)x levels were associated with the NOD-like receptors protein 3 (NLRP3), IL-1beta and caspase-1 inflammasome over-expression in splenorenal shunt and mesenteric tissues. Nitric Oxide 113-125 interleukin 1 beta Rattus norvegicus 202-210 26812205-4 2016 RESULTS: Hyperbaric oxygen therapy significantly inhibited the activation of the TLR4/NF-kappaB signaling pathway, reduced the expression of cleaved caspase-3, TNF-alpha, IL-6 and IL-1beta (P<0.05), reduced apoptosis of the neurons and improved the neurological function of the rats (P<0.05). Oxygen 20-26 interleukin 1 beta Rattus norvegicus 180-188 26518973-8 2016 Treatment with ALA significantly attenuated the levels of superoxide, gp91(phox), gp47(phox), ACE, AT1-R, IL-1beta and IL-6, increased the levels of IL-10 and Cu/Zn-SOD, and decreased MAP and RSNA compared with high-salt induced hypertensive rats. Thioctic Acid 15-18 interleukin 1 beta Rattus norvegicus 106-114 27168372-0 2016 Hippocampal distribution of IL-1beta and IL-1RI following lithium-pilocarpine-induced status epilepticus in the developing rat. lithium-pilocarpine 58-77 interleukin 1 beta Rattus norvegicus 28-36 26656757-6 2016 Mangiferin also reduced the content of malondialdehyde (MDA), IL-1beta and TNF-alpha, and up-regulated the activities of superoxide dismutase (SOD), glutathione (GSH) and IL-10 levels in the brain tissue of rats with the cerebral ischemia-reperfusion injury. mangiferin 0-10 interleukin 1 beta Rattus norvegicus 62-70 26745377-7 2016 rats, due to its anti-apoptotic, anti-oxidant and potentially anti-glutamate activities (NCM-induced IL-1beta can inhibit the glutamate-mediated neurotoxicity) and restriction upon the infiltration of inflammatory microglia into the core area of ischemic brain. Glutamic Acid 126-135 interleukin 1 beta Rattus norvegicus 101-109 26824000-0 2016 Combined effect of 17beta-estradiol and resveratrol against apoptosis induced by interleukin-1beta in rat nucleus pulposus cells via PI3K/Akt/caspase-3 pathway. Estradiol 19-35 interleukin 1 beta Rattus norvegicus 81-98 26824000-0 2016 Combined effect of 17beta-estradiol and resveratrol against apoptosis induced by interleukin-1beta in rat nucleus pulposus cells via PI3K/Akt/caspase-3 pathway. Resveratrol 40-51 interleukin 1 beta Rattus norvegicus 81-98 26761790-7 2016 Plasma levels of IL-1beta, TNFalpha and MIP-1alpha negatively correlated with Ach-induced relaxation throughout the course of AIA. Acetylcholine 78-81 interleukin 1 beta Rattus norvegicus 17-25 27168372-2 2016 The goal of this study was to determine the hippocampal expression of IL-1beta and its type 1 receptor (IL-1RI) following SE induced by the lithium-pilocarpine model in fourteen-days-old rat pups; control animals were given an equal volume of saline instead of the convulsant. lithium-pilocarpine 140-159 interleukin 1 beta Rattus norvegicus 70-78 27168372-2 2016 The goal of this study was to determine the hippocampal expression of IL-1beta and its type 1 receptor (IL-1RI) following SE induced by the lithium-pilocarpine model in fourteen-days-old rat pups; control animals were given an equal volume of saline instead of the convulsant. Sodium Chloride 243-249 interleukin 1 beta Rattus norvegicus 70-78 26671026-10 2016 Melatonin decreased the production of the inflammatory cytokines TNF-alpha, IL-1beta, and HMGB1, increased anti-oxidant enzyme activity, and decreased the expression of markers of oxidative damage. Melatonin 0-9 interleukin 1 beta Rattus norvegicus 76-84 27872853-0 2016 Controlled Release of Interleukin-1 Receptor Antagonist from Hyaluronic Acid-Chitosan Microspheres Attenuates Interleukin-1beta-Induced Inflammation and Apoptosis in Chondrocytes. Hyaluronic Acid 61-76 interleukin 1 beta Rattus norvegicus 110-127 27872853-1 2016 This paper investigates the protective effect of interleukin-1 receptor antagonist (IL-1Ra) released from hyaluronic acid chitosan (HA-CS) microspheres in a controlled manner on IL-1beta-induced inflammation and apoptosis in chondrocytes. hyaluronic acid chitosan 106-130 interleukin 1 beta Rattus norvegicus 178-186 27872853-1 2016 This paper investigates the protective effect of interleukin-1 receptor antagonist (IL-1Ra) released from hyaluronic acid chitosan (HA-CS) microspheres in a controlled manner on IL-1beta-induced inflammation and apoptosis in chondrocytes. ha-cs 132-137 interleukin 1 beta Rattus norvegicus 178-186 27066503-3 2016 Consumption of high-fructose diet for 24 weeks increased the expression of genes involved in insulin signaling including IR, IRS-1, IRS-2, Akt, PI3K, eNOS, mTOR, and PPARgamma, despite induction of proinflammatory markers, iNOS, TNFalpha, IL-1beta, IL-18, MDA, and ALT, as well as anti-inflammatory factors, IL-10 and Nrf2 in adipose tissues from males and females. Fructose 20-28 interleukin 1 beta Rattus norvegicus 239-247 27413737-8 2016 SGD or clopidogrel after CI-RP reduced TNF-alpha and IL-1beta levels in brain tissue and serum levels of MCP-1, IL-1beta, and IL-10. Clopidogrel 7-18 interleukin 1 beta Rattus norvegicus 53-61 27413737-8 2016 SGD or clopidogrel after CI-RP reduced TNF-alpha and IL-1beta levels in brain tissue and serum levels of MCP-1, IL-1beta, and IL-10. Clopidogrel 7-18 interleukin 1 beta Rattus norvegicus 112-120 27346180-8 2016 Although serum IL-1beta, IL-6, IL-18, TNF-alpha, and IFN- gamma levels have decreased in treatment group following melatonin administration, this decrement was statistically significant for serum IL-18, TNF-alpha, and IFN- gamma parameters compared with the IR group. Melatonin 115-124 interleukin 1 beta Rattus norvegicus 15-23 27872853-4 2016 The cell viability was decreased by IL-1beta, which was attenuated by HA-CS-IL-1Ra microspheres as indicated by an MTT assay. ha-cs 70-75 interleukin 1 beta Rattus norvegicus 36-44 27872853-4 2016 The cell viability was decreased by IL-1beta, which was attenuated by HA-CS-IL-1Ra microspheres as indicated by an MTT assay. monooxyethylene trimethylolpropane tristearate 115-118 interleukin 1 beta Rattus norvegicus 36-44 27872853-5 2016 ELISA showed that HA-CS-IL-1Ra microspheres inhibited IL-1beta-induced inflammation by attenuating increases in NO2- and prostaglandin E2 levels as well as increase in glycosaminoglycan release. Nitrogen Dioxide 112-115 interleukin 1 beta Rattus norvegicus 54-62 27872853-5 2016 ELISA showed that HA-CS-IL-1Ra microspheres inhibited IL-1beta-induced inflammation by attenuating increases in NO2- and prostaglandin E2 levels as well as increase in glycosaminoglycan release. Dinoprostone 121-137 interleukin 1 beta Rattus norvegicus 54-62 27872853-5 2016 ELISA showed that HA-CS-IL-1Ra microspheres inhibited IL-1beta-induced inflammation by attenuating increases in NO2- and prostaglandin E2 levels as well as increase in glycosaminoglycan release. Glycosaminoglycans 168-185 interleukin 1 beta Rattus norvegicus 54-62 27872853-6 2016 A terminal deoxyribonucleotide transferase deoxyuridine triphosphate nick-end labeling assay revealed that the IL-1beta-induced chondrocyte apoptosis was decreased by HA-CS-IL-1Ra microspheres. deoxyuridine triphosphate 43-68 interleukin 1 beta Rattus norvegicus 111-119 27195281-11 2016 In addition, plasma concentrations of TNF-alpha, IL-6, and IL-1beta were significantly lower in the CLP+Cit 6-hour group than in the CLP 6-hour group. Citrulline 104-107 interleukin 1 beta Rattus norvegicus 59-67 25938977-2 2016 Ebosin, a novel exopolysaccharide (EPS), exhibits anti-inflammatory activity in rat collagen-induced arthritis by suppressing the production of tumor necrosis factor-alpha, interleukin-6 and interleukin-1beta. exopolysaccharide 16-33 interleukin 1 beta Rattus norvegicus 191-208 26254235-9 2016 The effect of METH on HMGB1 and IL-1beta in striatal tissue was then measured. Methamphetamine 14-18 interleukin 1 beta Rattus norvegicus 32-40 26254235-13 2016 In particular, METH induced profound effects on IL-1beta in NAcc (2h) and PFC (2h and 4h). Methamphetamine 15-19 interleukin 1 beta Rattus norvegicus 48-56 26254235-13 2016 In particular, METH induced profound effects on IL-1beta in NAcc (2h) and PFC (2h and 4h). Deuterium 66-68 interleukin 1 beta Rattus norvegicus 48-56 26254235-13 2016 In particular, METH induced profound effects on IL-1beta in NAcc (2h) and PFC (2h and 4h). Deuterium 79-81 interleukin 1 beta Rattus norvegicus 48-56 26254235-13 2016 In particular, METH induced profound effects on IL-1beta in NAcc (2h) and PFC (2h and 4h). 4h 86-88 interleukin 1 beta Rattus norvegicus 48-56 26254235-14 2016 Exposure of microglia to METH in vitro failed to induce a pro-inflammatory response, but rather induced significant cell death as well as a decrease in IL-1beta. Methamphetamine 25-29 interleukin 1 beta Rattus norvegicus 152-160 26254235-15 2016 METH treatment increased HMGB1 in parallel with IL-1beta in striatum. Methamphetamine 0-4 interleukin 1 beta Rattus norvegicus 48-56 26254235-16 2016 Pre-treatment with the HMGB1 antagonist box A blocked the neuroinflammatory effects (IL-1beta) of METH in NAcc, VTA and PFC. Methamphetamine 98-102 interleukin 1 beta Rattus norvegicus 85-93 25938977-2 2016 Ebosin, a novel exopolysaccharide (EPS), exhibits anti-inflammatory activity in rat collagen-induced arthritis by suppressing the production of tumor necrosis factor-alpha, interleukin-6 and interleukin-1beta. eps 35-38 interleukin 1 beta Rattus norvegicus 191-208 26741705-1 2016 BACKGROUND/AIMS: A recent study demonstrates that pro-inflammatory cytokines (PICs, i.e., IL-1beta, IL-6 and TNF-alpha) in specific brain regions of rats play a role in regulating kainic acid (KA)-induced status epilepticus (SE) via a GABAergic mechanism. Kainic Acid 180-191 interleukin 1 beta Rattus norvegicus 90-98 27997926-5 2016 RESULTS: H2S attenuated HG-induced cell apoptosis, ROS expression and loss of MMP and reduced the expression of NLRP3, ASC, pro-caspase-1, caspase-1, IL-1beta, IL-18 and caspase-3. Hydrogen Sulfide 9-12 interleukin 1 beta Rattus norvegicus 150-158 26904148-6 2016 The production of inflammatory cytokines, such as TNF-alpha, IL-1beta, and IL-6, was markedly inhibited by GA. Glycyrrhizic Acid 107-109 interleukin 1 beta Rattus norvegicus 61-69 26517155-12 2016 Furthermore, arjunolic acid showed dose dependent reduction in cisplatin-induced elevation in renal levels of TGF-betaR1, TGF-beta1, TNF-alpha, IL-1beta and caspases. arjunolic acid 13-27 interleukin 1 beta Rattus norvegicus 144-165 26517155-12 2016 Furthermore, arjunolic acid showed dose dependent reduction in cisplatin-induced elevation in renal levels of TGF-betaR1, TGF-beta1, TNF-alpha, IL-1beta and caspases. Cisplatin 63-72 interleukin 1 beta Rattus norvegicus 144-165 27455577-2 2016 Methanol antidote 4-methylpyrazole (non-competitive inhibitor of alcohol dehydrogenase) administered upon acute intoxication with methanol at a dose of 1.0 DL50 partially reduces the intoxication-induced suppression of humoral and cellular immune response, activity of T-helper cells, and production of IL-4 and restores blood levels of TNF, IL-1b, IFN-gamma, IL-4, IL-2, IL-6 to the control values. Methanol 0-8 interleukin 1 beta Rattus norvegicus 342-347 27455577-2 2016 Methanol antidote 4-methylpyrazole (non-competitive inhibitor of alcohol dehydrogenase) administered upon acute intoxication with methanol at a dose of 1.0 DL50 partially reduces the intoxication-induced suppression of humoral and cellular immune response, activity of T-helper cells, and production of IL-4 and restores blood levels of TNF, IL-1b, IFN-gamma, IL-4, IL-2, IL-6 to the control values. Fomepizole 18-34 interleukin 1 beta Rattus norvegicus 342-347 27455577-2 2016 Methanol antidote 4-methylpyrazole (non-competitive inhibitor of alcohol dehydrogenase) administered upon acute intoxication with methanol at a dose of 1.0 DL50 partially reduces the intoxication-induced suppression of humoral and cellular immune response, activity of T-helper cells, and production of IL-4 and restores blood levels of TNF, IL-1b, IFN-gamma, IL-4, IL-2, IL-6 to the control values. Methanol 130-138 interleukin 1 beta Rattus norvegicus 342-347 26527061-4 2016 8-Bromo cAMP significantly enhanced IL-1beta-induced STAT3 phosphorylation without affecting phosphorylation of IkappaB, p38 MAP kinase or SAPK/JNK. 8-bromo 0-7 interleukin 1 beta Rattus norvegicus 36-44 26527061-5 2016 In addition, we found that forskolin, a direct activator of adenylyl cyclase, significantly enhanced IL-1beta-induced STAT3 phosphorylation. Colforsin 27-36 interleukin 1 beta Rattus norvegicus 101-109 26527061-7 2016 IL-1beta induced JAK2 phosphorylation, and FLLL32, a specific JAK2 inhibitor, significantly reduced IL-1beta-stimulated IL-6 release. FLLL 32 43-49 interleukin 1 beta Rattus norvegicus 100-108 26527061-8 2016 4-Cyano-3-methylisoquinoline, an inhibitor of protein kinase A (PKA), significantly attenuated the enhancing effect of 8-bromo cAMP on IL-1beta-induced STAT3 phosphorylation. 4-cyano-3-methylisoquinoline 0-28 interleukin 1 beta Rattus norvegicus 135-143 26745386-7 2016 In addition, TCBQ significantly induced protein and mRNA expressions of inflammatory cytokines and mediators, such as interleukin-1 beta (IL-1beta), IL-6, tumor necrosis factor-alpha (TNF-alpha), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and the production of nitric oxide (NO) and prostaglandin E2 (PGE2). tetrachlorobenzoquinone 13-17 interleukin 1 beta Rattus norvegicus 118-136 26745386-7 2016 In addition, TCBQ significantly induced protein and mRNA expressions of inflammatory cytokines and mediators, such as interleukin-1 beta (IL-1beta), IL-6, tumor necrosis factor-alpha (TNF-alpha), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and the production of nitric oxide (NO) and prostaglandin E2 (PGE2). tetrachlorobenzoquinone 13-17 interleukin 1 beta Rattus norvegicus 138-146 27556049-8 2016 Interestingly, in contrast to MTX, N-f-5HT significantly lowered the level of IL-1beta in plasma and IL-1beta mRNA expression in the liver and spleen of arthritic rats. n-f-5ht 35-42 interleukin 1 beta Rattus norvegicus 78-86 26644168-11 2016 In addition, levels of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and high mobility group box 1 in the serum were also lowered by betulin treatment. betulin 149-156 interleukin 1 beta Rattus norvegicus 52-69 28116212-8 2016 Minocycline, an inhibitor of microglial activation, inhibited the increase in neuronal activity and attenuated the increase in IL-1beta, Csf1, CX3L1, and CX3CR1 expression in NP tissue. Minocycline 0-11 interleukin 1 beta Rattus norvegicus 127-135 26931452-0 2016 Methylprednisolone blocks interleukin 1 beta induced calcitonin gene related peptide release in trigeminal ganglia cells. Methylprednisolone 0-18 interleukin 1 beta Rattus norvegicus 26-44 26135783-10 2016 Furthermore, the hyperoxia + Dxp group had lower tumor necrosis factor-alpha and interleukin-1beta median levels compared to the hyperoxia group (p = 0.007). dexpanthenol 29-32 interleukin 1 beta Rattus norvegicus 81-98 28105061-14 2016 Ginsenoside Rg3 also caused significant reductions of the contents of TNF-alpha and IL-1beta in left ventricles of myocardial I/R-rats. Ginsenosides 0-11 interleukin 1 beta Rattus norvegicus 84-92 26499137-7 2016 Indomethacin-induced rats also exhibited considerable increases of pro-inflammatory cytokines including interleukin-6 (IL-6), interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) levels and decreases of anti-inflammatory cytokines such as interleukin-10 (IL-10) and interleukin-4 (IL-4), but these imbalances were normalized through treatment of TRG. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 126-143 26499137-7 2016 Indomethacin-induced rats also exhibited considerable increases of pro-inflammatory cytokines including interleukin-6 (IL-6), interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) levels and decreases of anti-inflammatory cytokines such as interleukin-10 (IL-10) and interleukin-4 (IL-4), but these imbalances were normalized through treatment of TRG. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 145-153 26679676-12 2016 The mRNA expression and protein level of TNF-alpha and the mRNA of IL-1beta and MMP-9 were progressively and markedly reduced in bilirubin-treated rats. Bilirubin 129-138 interleukin 1 beta Rattus norvegicus 67-75 26679678-6 2016 It was found that pretreatment with ICA could decrease neurological deficit score, diminish the infarct volume, and reduce the protein levels of IL-1beta and TGF-beta1. icariin 36-39 interleukin 1 beta Rattus norvegicus 145-153 27556049-8 2016 Interestingly, in contrast to MTX, N-f-5HT significantly lowered the level of IL-1beta in plasma and IL-1beta mRNA expression in the liver and spleen of arthritic rats. n-f-5ht 35-42 interleukin 1 beta Rattus norvegicus 101-109 26517535-9 2016 MTX also increased IL-1beta (40.33 +- 5.43 gene expression levels), TNF-alpha (6.08 +- 0.59) and MPO gene expression (9 +- 1.41) in group 1 compared to the controls (11.33 +- 2.07, 2.15 +- 0.33 and 3.43 +- 0.48, respectively, p < 0.001). Methotrexate 0-3 interleukin 1 beta Rattus norvegicus 19-27 26511903-9 2016 Increased plasma TNF-alpha, IL-1beta levels, along with decreased BDNF, S100B and IL-10 values were observed in the saline-treated PHZ group, while these changes were all reversed in the melatonin-treated group. Melatonin 187-196 interleukin 1 beta Rattus norvegicus 28-36 26517535-10 2016 The impact of RST on IL-1beta, TNF-alpha and MPO gene expression induced by MTX was observed as a reversal of these findings (p < 0.05). Methotrexate 76-79 interleukin 1 beta Rattus norvegicus 21-29 27413256-7 2016 In addition, the inflammation reactions and the increased expression of IL-1beta could be restrained by treatment with TAK-242, a blocker of TLR4 signaling. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 119-126 interleukin 1 beta Rattus norvegicus 72-80 26980948-7 2016 Moreover, administration of SB239063, an inhibitor of P38 alpha and beta, could effectively downregulate the expressions of IL-1beta and protects lung tissues from injury in II/R rats. SB 239063 28-36 interleukin 1 beta Rattus norvegicus 124-132 26798415-9 2016 Treatment with obestatin after induction of colitis accelerated the healing of colonic wall damage and this effect was associated with a decrease in the colitis-evoked increase in mucosal activity of myeloperoxidase and content of interleukin-1beta. Ghrelin 15-24 interleukin 1 beta Rattus norvegicus 231-248 25978596-5 2016 Furthermore, isofuranodiene treatment significantly inhibited GalN/LPS-induced mRNA expression of IL-1beta, IL-6 and inducible nitric oxide synthase in liver tissues. isofuranodiene 13-27 interleukin 1 beta Rattus norvegicus 98-106 25978596-5 2016 Furthermore, isofuranodiene treatment significantly inhibited GalN/LPS-induced mRNA expression of IL-1beta, IL-6 and inducible nitric oxide synthase in liver tissues. Galactosamine 62-66 interleukin 1 beta Rattus norvegicus 98-106 26337121-10 2016 In addition, mRNA protein levels of the cytokines interleukin-1beta (IL1beta), IL18 and TNFalpha were reduced by the steroids. Steroids 117-125 interleukin 1 beta Rattus norvegicus 50-67 26337121-10 2016 In addition, mRNA protein levels of the cytokines interleukin-1beta (IL1beta), IL18 and TNFalpha were reduced by the steroids. Steroids 117-125 interleukin 1 beta Rattus norvegicus 69-76 27524867-7 2016 Our data show that imperialine mitigates pulmonary functional and structural impairment and suppressed inflammatory response in a COPD-like rat model by mediating expression of related cytokines in lung tissues of the COPD-like rats, such as IL-1beta, IL-6, IL-8, TNF-alpha, NF-kappaB, TGF-beta1, MMP-9, and TIMP-1. peiminine 19-30 interleukin 1 beta Rattus norvegicus 242-250 26798422-6 2016 Oligonol treatment attenuated the CCl4-induced production of inflammatory mediators, including TNF-alpha, IL-1beta, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) mRNA levels. oligonol 0-8 interleukin 1 beta Rattus norvegicus 106-114 27069534-6 2016 Our results demonstrated that consuming a mixture of alcohol and ED for 60 days induced an increase in reactive gliosis, IL-1beta, TNF-alpha, iNOS, reactive oxygen species, lipid peroxidation, and nitric oxide, in the TCx and Hp. Alcohols 53-60 interleukin 1 beta Rattus norvegicus 121-129 27143993-10 2016 The production of proinflammatory cytokines and proteins, including interleukin 1beta, TNF-alpha, and inducible nitric oxide synthase (iNOS), was inhibited by melatonin through the NF-kappaB pathway. Melatonin 159-168 interleukin 1 beta Rattus norvegicus 68-85 26895214-8 2016 PDTC and NAC markedly decreased the protein expression of IL-1beta (p < 0.01) and increased the protein expression of DIO1 (p < 0.01), respectively. Acetylcysteine 9-12 interleukin 1 beta Rattus norvegicus 58-66 27274777-0 2016 Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-beta, and TNF-alpha Production and Inhibiting NF-kappaB and Caspase-3 Expression. Carvedilol 22-32 interleukin 1 beta Rattus norvegicus 119-127 27274777-0 2016 Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-beta, and TNF-alpha Production and Inhibiting NF-kappaB and Caspase-3 Expression. Ascorbic Acid 37-46 interleukin 1 beta Rattus norvegicus 119-127 27274777-11 2016 Carvedilol and vitamin C decreased lactate dehydrogenase, malondialdehyde, IL1-beta, TNF-alpha, NF-kappaB, and caspase-3. Carvedilol 0-10 interleukin 1 beta Rattus norvegicus 75-83 27274777-11 2016 Carvedilol and vitamin C decreased lactate dehydrogenase, malondialdehyde, IL1-beta, TNF-alpha, NF-kappaB, and caspase-3. Ascorbic Acid 15-24 interleukin 1 beta Rattus norvegicus 75-83 26977316-8 2016 TNF-alpha, IL-1beta, and MDA levels and hydroxyproline content significantly increased (p < 0.01) and GPx and SOD activities significantly decreased in bleomycin group (p < 0.01). Bleomycin 155-164 interleukin 1 beta Rattus norvegicus 11-19 26977316-9 2016 Naringin at a dose of 80 mg/kg body weight significantly decreased TNF-alpha and IL-1beta activity, hydroxyproline content, and MDA level (p < 0.01) and increased GPx and SOD activities (p < 0.05). naringin 0-8 interleukin 1 beta Rattus norvegicus 81-89 26688329-10 2016 SB203580 (p38 inhibitor) partly prevented the change in NO, IL-10, IL-1beta, TNF-alpha levels induced by EMP exposure. SB 203580 0-8 interleukin 1 beta Rattus norvegicus 67-75 26535964-6 2016 Our results demonstrate that only the stressed animals that were characterized by a deficit in sucrose intake showed increased expression of the pro-inflammatory cytokines IL-1beta, IL-6 and up-regulation of markers and mediators of microglia activation such as CD11b, CX3CL1 and its receptor CX3CR1 in comparison with stress-resilient animals. Sucrose 95-102 interleukin 1 beta Rattus norvegicus 172-180 27803479-1 2016 Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression is induced by interleukin-1beta (IL-1beta) stimulation in vascular smooth muscle cells (VSMCs), resulting in the production of nitric oxide and prostaglandins such as PGI2. Nitric Oxide 10-22 interleukin 1 beta Rattus norvegicus 93-110 27803479-4 2016 Docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, potentiates IL-1beta-induced iNOS and COX-2 expression in VSMCs isolated from WKY, but not those from SHRSP. Docosahexaenoic Acids 22-25 interleukin 1 beta Rattus norvegicus 75-83 27803479-1 2016 Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression is induced by interleukin-1beta (IL-1beta) stimulation in vascular smooth muscle cells (VSMCs), resulting in the production of nitric oxide and prostaglandins such as PGI2. Nitric Oxide 10-22 interleukin 1 beta Rattus norvegicus 112-120 27803479-4 2016 Docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, potentiates IL-1beta-induced iNOS and COX-2 expression in VSMCs isolated from WKY, but not those from SHRSP. Fatty Acids, Omega-3 31-61 interleukin 1 beta Rattus norvegicus 75-83 27803479-1 2016 Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression is induced by interleukin-1beta (IL-1beta) stimulation in vascular smooth muscle cells (VSMCs), resulting in the production of nitric oxide and prostaglandins such as PGI2. Prostaglandins 223-237 interleukin 1 beta Rattus norvegicus 93-110 27803479-1 2016 Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression is induced by interleukin-1beta (IL-1beta) stimulation in vascular smooth muscle cells (VSMCs), resulting in the production of nitric oxide and prostaglandins such as PGI2. Prostaglandins 223-237 interleukin 1 beta Rattus norvegicus 112-120 27803479-1 2016 Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression is induced by interleukin-1beta (IL-1beta) stimulation in vascular smooth muscle cells (VSMCs), resulting in the production of nitric oxide and prostaglandins such as PGI2. Epoprostenol 246-250 interleukin 1 beta Rattus norvegicus 93-110 27803479-1 2016 Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression is induced by interleukin-1beta (IL-1beta) stimulation in vascular smooth muscle cells (VSMCs), resulting in the production of nitric oxide and prostaglandins such as PGI2. Epoprostenol 246-250 interleukin 1 beta Rattus norvegicus 112-120 27803479-4 2016 Docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, potentiates IL-1beta-induced iNOS and COX-2 expression in VSMCs isolated from WKY, but not those from SHRSP. Docosahexaenoic Acids 0-20 interleukin 1 beta Rattus norvegicus 75-83 26528797-0 2015 Levosimendan inhibits interleukin-1beta-induced apoptosis through activation of Akt and inhibition of inducible nitric oxide synthase in rat cardiac fibroblasts. Simendan 0-12 interleukin 1 beta Rattus norvegicus 22-39 26561928-14 2015 The level of TNF-alpha, IL-1beta, and COX-2 was also decreased with GA treatment in NR8383 cells that had been stimulated with lipopolysaccharide (LPS). Gallium 68-70 interleukin 1 beta Rattus norvegicus 24-32 26528797-3 2015 The aim of this study was to examine whether levosimendan modulates interleukin (IL)-1beta-induced apoptosis in adult rat cardiac fibroblast. Simendan 45-57 interleukin 1 beta Rattus norvegicus 68-90 26528797-9 2015 Levosimendan (3-100muM) concentration-dependently inhibited IL-1beta (4ng/ml, 24h)-induced apoptotic changes in cardiac fibroblasts, such as cellular shrinkage, nuclear condensation and the increase of TUNEL-positive cells. Simendan 0-12 interleukin 1 beta Rattus norvegicus 60-68 26528797-9 2015 Levosimendan (3-100muM) concentration-dependently inhibited IL-1beta (4ng/ml, 24h)-induced apoptotic changes in cardiac fibroblasts, such as cellular shrinkage, nuclear condensation and the increase of TUNEL-positive cells. 3-100mum 14-22 interleukin 1 beta Rattus norvegicus 60-68 26528797-9 2015 Levosimendan (3-100muM) concentration-dependently inhibited IL-1beta (4ng/ml, 24h)-induced apoptotic changes in cardiac fibroblasts, such as cellular shrinkage, nuclear condensation and the increase of TUNEL-positive cells. 9-(3-hydroxy-2-phosphonomethoxypropyl)guanine 78-81 interleukin 1 beta Rattus norvegicus 60-68 26528797-10 2015 Levosimendan inhibited IL-1beta-induced iNOS expression and subsequent NO production. Simendan 0-12 interleukin 1 beta Rattus norvegicus 23-31 26610718-7 2015 Treatment with hesperetin dramatically improved the histology of lung tissue, and reduced the wet/dry ratio, myeloperoxidase activity, protein concentration, and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-1beta, and MIP-2 in the bronchoalveolar lavage fluid of rats with ventilator-induced acute lung injury. hesperetin 15-25 interleukin 1 beta Rattus norvegicus 231-239 26703073-12 2015 Indomethacin reduced IL-1beta and knee joint pain but failed to improve hydrarthrosis or HA concentration in rats with OA. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 21-29 26528797-11 2015 1400W, an iNOS inhibitor, suppressed the IL-1beta-induced apoptosis. N-((3-(aminomethyl)phenyl)methyl)ethanimidamide 0-5 interleukin 1 beta Rattus norvegicus 41-49 26528797-13 2015 LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, reversed the protective effect of levosimendan on IL-1beta-induced apoptosis in TUNEL assay. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 interleukin 1 beta Rattus norvegicus 110-118 26528797-13 2015 LY294002, a phosphatidylinositol 3-kinase (PI3K) inhibitor, reversed the protective effect of levosimendan on IL-1beta-induced apoptosis in TUNEL assay. Simendan 94-106 interleukin 1 beta Rattus norvegicus 110-118 26528797-14 2015 In addition, levosimendan and 1400W inhibited the IL-1beta-induced cytosolic translocation of cytochrome-c. LY294002 reversed the suppressive effects of levosimendan. Simendan 13-25 interleukin 1 beta Rattus norvegicus 50-58 26528797-14 2015 In addition, levosimendan and 1400W inhibited the IL-1beta-induced cytosolic translocation of cytochrome-c. LY294002 reversed the suppressive effects of levosimendan. N-((3-(aminomethyl)phenyl)methyl)ethanimidamide 30-35 interleukin 1 beta Rattus norvegicus 50-58 26528797-14 2015 In addition, levosimendan and 1400W inhibited the IL-1beta-induced cytosolic translocation of cytochrome-c. LY294002 reversed the suppressive effects of levosimendan. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 108-116 interleukin 1 beta Rattus norvegicus 50-58 26528797-14 2015 In addition, levosimendan and 1400W inhibited the IL-1beta-induced cytosolic translocation of cytochrome-c. LY294002 reversed the suppressive effects of levosimendan. Simendan 153-165 interleukin 1 beta Rattus norvegicus 50-58 26528797-15 2015 The present study for the first time demonstrated that levosimendan inhibits IL-1beta-induced apoptosis via the activation of PI3K/Akt pathway and the inhibition of iNOS expression in adult rat cardiac fibroblasts. Simendan 55-67 interleukin 1 beta Rattus norvegicus 77-85 26669668-8 2015 TFB can inhibit the production of IL-6, IL-1beta, and TNF-alpha from serum. tfb 0-3 interleukin 1 beta Rattus norvegicus 40-48 26511504-12 2015 ADM pretreatment inhibited IL-1beta-induced inflammation in Leydig cells by decreasing the gene expression levels of iNOS and COX-2, as well as the concentrations of NO and PGE2. Dinoprostone 173-177 interleukin 1 beta Rattus norvegicus 27-35 26658436-4 2015 We have shown, in vitro, that celastrol inhibits both IL-1beta and TNF, which play an important role in RA, and, in vivo, that celastrol has significant anti-inflammatory properties. celastrol 30-39 interleukin 1 beta Rattus norvegicus 54-62 26424290-10 2015 In contrast, QGYD and combination QGYD and ceftazidime treatment restored the elevated serum IL-1beta and Th1/Th2 levels to normal (P>0.05). Ceftazidime 43-54 interleukin 1 beta Rattus norvegicus 93-101 26522475-10 2015 Besides, ethanol-induced pro-inflammatory response was significantly decreased by apocynin pre-treatment via reducing elevated levels of pro-inflammatory markers; interleukin-1beta, tumor necrosis factor-alpha, cyclooxygenase-2 and inducible nitric oxide synthase. Ethanol 9-16 interleukin 1 beta Rattus norvegicus 163-209 26522475-10 2015 Besides, ethanol-induced pro-inflammatory response was significantly decreased by apocynin pre-treatment via reducing elevated levels of pro-inflammatory markers; interleukin-1beta, tumor necrosis factor-alpha, cyclooxygenase-2 and inducible nitric oxide synthase. acetovanillone 82-90 interleukin 1 beta Rattus norvegicus 163-209 26426856-9 2015 The beta2-adrenoceptor agonist terbutaline was sufficient to enhance the skin expression of TNF-alpha and IL-1beta and to increase 5-HT-induced scratching in naive rats. Terbutaline 31-42 interleukin 1 beta Rattus norvegicus 106-114 26427494-10 2015 Immunohistochemical analyses showed that CcL (1 mg/kg) reduced the expression of the cytokines IL-1beta, TNF-alpha, IL-6 and COX-2. Cefaclor 41-44 interleukin 1 beta Rattus norvegicus 95-103 25410748-9 2015 Also, in these animals, administration of DSS induced a significant increase in interleukin (IL)-1alpha, IL-1beta and IL-6. dss 42-45 interleukin 1 beta Rattus norvegicus 105-113 26668605-10 2015 The levels of cytokine-induced neutrophil chemoattractant-1, IL-1beta, and TNF-alpha in bronchoalveolar lavage fluid were also markedly reduced following BMCS infusion. S-benzyl-N-malonylcysteine 154-158 interleukin 1 beta Rattus norvegicus 61-69 26427494-16 2015 CONCLUSIONS: The anti-inflammatory action of CcL involves the inhibition of IL-1beta, TNF-alpha, IL-6 and COX-2 expression and histamine H1 receptors. Cefaclor 45-48 interleukin 1 beta Rattus norvegicus 76-84 26182997-9 2015 RESULTS: Hydrogen water consumption reduced wet-to-dry weight ratio, malondialdehyde and myeloperoxidase activity and decreased the concentration of TNF-alpha, IL-1beta, and IL-6 in the lung tissues compared with sham group and sham + H2 group. hydrogen water 9-23 interleukin 1 beta Rattus norvegicus 160-168 26453508-6 2015 CGP treatment also inhibited the TNBS-mediated increases in nitric oxide synthase, cyclooxygenase-2, interleukin-1beta, tumor necrosis factor-alpha, intercellular adhesion molecule-1, and monocyte chemotactic protein-1 proteins or mRNA levels. Trinitrobenzenesulfonic Acid 33-37 interleukin 1 beta Rattus norvegicus 101-147 25645818-13 2015 Western blot analysis showed that puerarin (200 mg/kg) inhibited the activation of nuclear factor-kappa B p65, which is associated with lower IL-1beta and TNF-alpha production, and reduced the glycosylation of extracellular matrix metalloproteinase inducer, which is associated with lower levels of MMP-2 and MMP-9. puerarin 34-42 interleukin 1 beta Rattus norvegicus 142-150 25645818-14 2015 CONCLUSIONS: Puerarin reduced the alveolar bone loss and collagen destruction in rats with ligature-induced periodontitis by inhibiting the production of RANKL, IL-1beta, TNF-alpha, MMP-2 and MMP-9. puerarin 13-21 interleukin 1 beta Rattus norvegicus 161-169 25736698-12 2015 Piperine (100 mg/kg) significantly downregulated the expressions of IL-1beta, MMP-8 and MMP-13 in periodontitis, but not that of TNF-alpha. piperine 0-8 interleukin 1 beta Rattus norvegicus 68-76 26525983-11 2015 Compared with sinomenine, the derivatives significantly inhibited the expression of the inflammatory factors IL-1beta and IL-6 at the transcriptional and translational levels. sinomenine 14-24 interleukin 1 beta Rattus norvegicus 109-117 26401980-7 2015 RESULTS: The concentrations of IL-1beta, IL-2, and IL-6 in the conjunctiva were significantly lower in the brimonidine group (P = 0.033, 0.017, and 0.016, respectively) than in the control group. Brimonidine Tartrate 107-118 interleukin 1 beta Rattus norvegicus 31-39 26401980-9 2015 However, in the analysis of the cytokines in the aqueous humor, the concentrations of IL-1beta and IL-2 were significantly higher in the brimonidine group than in the control group (P = 0.016 and 0.008, respectively). Brimonidine Tartrate 137-148 interleukin 1 beta Rattus norvegicus 86-94 26769837-16 2015 Moreover, ghrelin administration reduced mucosal concentration of IL-1beta and MDA, as well as decreased mucosal activity of myeloperoxidase. Ghrelin 10-17 interleukin 1 beta Rattus norvegicus 66-74 25367879-5 2015 In addition, BAY 43-9006 treatment significantly reversed the phosphorylation of ERK1/2 and the activation of NF-kappaB induced by SAH and decreased the messenger RNA (mRNA) levels of IL-6 and IL-1beta. Sorafenib 13-24 interleukin 1 beta Rattus norvegicus 193-201 26640368-17 2015 Moreover, the mucoadhesive microspheres loaded with alkaloids reduce the inflammatory response by decreasing the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), downregulating the mRNA expression of inducible nitric oxide synthase, TNF-alpha, and IL-1beta in gastric mucosa. Alkaloids 52-61 interleukin 1 beta Rattus norvegicus 280-288 26496827-10 2015 In addition, harmine significantly increased the protein expression of GLT-1, and markedly attenuated the expression levels of interleukin-1beta and tumor necrosis factor-alpha, thereby attenuating apoptotic neuronal death in the hippocampus. Harmine 13-20 interleukin 1 beta Rattus norvegicus 127-176 26987229-2 2015 To achieve this, we studied the effect of intravenous administration of IL-1beta during inhibition of NO-synthase by N-nitro-L-arginine methyl ester (L-NAME, a non-specific blocker of NO-synthase) on the parameters of breathing and the Hering-Breuer inspiratory-inhibitory reflex. NG-Nitroarginine Methyl Ester 150-156 interleukin 1 beta Rattus norvegicus 72-80 26987229-3 2015 It was shown that the effect of L-NAME eliminates the IL-1beta-dependent increase of the Hering-Breuer reflex, whereas effects on breathing pattern does not change: the increase in IL-1beta system-level evokes an increase in respiratory rate, tidal volume and lung ventilation. NG-Nitroarginine Methyl Ester 32-38 interleukin 1 beta Rattus norvegicus 54-62 26987229-3 2015 It was shown that the effect of L-NAME eliminates the IL-1beta-dependent increase of the Hering-Breuer reflex, whereas effects on breathing pattern does not change: the increase in IL-1beta system-level evokes an increase in respiratory rate, tidal volume and lung ventilation. NG-Nitroarginine Methyl Ester 32-38 interleukin 1 beta Rattus norvegicus 181-189 26987229-4 2015 It is assumed that one of the mechanisms of enhance in the strength inspiratory-inhibitory reflex by increasing circulatory IL-1beta level is the increased glutamate-ergic transmission on pump-neurons induced by increase in nitric oxide synthesis in cerebrovascular endothelial cells. Glutamic Acid 156-165 interleukin 1 beta Rattus norvegicus 124-132 26987229-4 2015 It is assumed that one of the mechanisms of enhance in the strength inspiratory-inhibitory reflex by increasing circulatory IL-1beta level is the increased glutamate-ergic transmission on pump-neurons induced by increase in nitric oxide synthesis in cerebrovascular endothelial cells. Nitric Oxide 224-236 interleukin 1 beta Rattus norvegicus 124-132 26640368-17 2015 Moreover, the mucoadhesive microspheres loaded with alkaloids reduce the inflammatory response by decreasing the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), downregulating the mRNA expression of inducible nitric oxide synthase, TNF-alpha, and IL-1beta in gastric mucosa. Alkaloids 52-61 interleukin 1 beta Rattus norvegicus 164-181 26640368-17 2015 Moreover, the mucoadhesive microspheres loaded with alkaloids reduce the inflammatory response by decreasing the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), downregulating the mRNA expression of inducible nitric oxide synthase, TNF-alpha, and IL-1beta in gastric mucosa. Alkaloids 52-61 interleukin 1 beta Rattus norvegicus 183-191 26572488-6 2015 Sorafenib significantly inhibited the expression of angiogenesis-associated cell markers and cytokines, including CD31, von Willebrand factor (vWF), and vascular endothelial growth factor, whereas GdCl3 suppressed macrophage-related cell markers and cytokines, including CD68, tumor necrosis factor-alpha, interleukin-1beta, and CCL2. Sorafenib 0-9 interleukin 1 beta Rattus norvegicus 306-323 26344001-5 2015 This IL-1beta expression in OASFs is attenuated by N-acetylcysteine (NAC), inhibitors of ASK1, p38, or JNK, or treatment with berberine. Acetylcysteine 69-72 interleukin 1 beta Rattus norvegicus 5-13 26344001-5 2015 This IL-1beta expression in OASFs is attenuated by N-acetylcysteine (NAC), inhibitors of ASK1, p38, or JNK, or treatment with berberine. Berberine 126-135 interleukin 1 beta Rattus norvegicus 5-13 26344001-0 2015 Berberine attenuates CCN2-induced IL-1beta expression and prevents cartilage degradation in a rat model of osteoarthritis. Berberine 0-9 interleukin 1 beta Rattus norvegicus 34-42 26344001-4 2015 We showed that CCN2-induced IL-1beta expression is mediated by the activation of alphavbeta3/alphavbeta5 integrin-dependent reactive oxygen species (ROS) generation, and subsequent activation of apoptosis signal-regulating kinase 1 (ASK1), p38/JNK, and nuclear factor-kappaB (NF-kappaB) signaling pathways. Reactive Oxygen Species 124-147 interleukin 1 beta Rattus norvegicus 28-36 26344001-4 2015 We showed that CCN2-induced IL-1beta expression is mediated by the activation of alphavbeta3/alphavbeta5 integrin-dependent reactive oxygen species (ROS) generation, and subsequent activation of apoptosis signal-regulating kinase 1 (ASK1), p38/JNK, and nuclear factor-kappaB (NF-kappaB) signaling pathways. Reactive Oxygen Species 149-152 interleukin 1 beta Rattus norvegicus 28-36 26344001-5 2015 This IL-1beta expression in OASFs is attenuated by N-acetylcysteine (NAC), inhibitors of ASK1, p38, or JNK, or treatment with berberine. Acetylcysteine 51-67 interleukin 1 beta Rattus norvegicus 5-13 26344001-7 2015 We observed that CCN2 increased IL-1beta expression via alphavbeta3/alphavbeta5 integrins, ROS, and ASK1, p38/JNK, and NF-kappaB signaling pathways. Reactive Oxygen Species 91-94 interleukin 1 beta Rattus norvegicus 32-40 26290366-0 2015 Acute reactive oxygen species (ROS)-dependent effects of IL-1beta, TNF-alpha, and IL-6 on the glomerular filtration barrier (GFB) in vivo. Reactive Oxygen Species 6-29 interleukin 1 beta Rattus norvegicus 57-65 26562417-12 2015 Fetuses of mothers fed a high fructose diet displayed increased hepatic fructose transporter and reduced fructokinase mRNA levels and by 10 days of postnatal age, also have hepatic ER stress, and elevated IL1beta mRNA levels. Fructose 30-38 interleukin 1 beta Rattus norvegicus 205-212 26556241-7 2015 TAK-242 suppresses cardiac and renal inflammatory cytokines levels (TNF-a, IL-1beta and MCP-1). ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 0-7 interleukin 1 beta Rattus norvegicus 75-83 26290366-0 2015 Acute reactive oxygen species (ROS)-dependent effects of IL-1beta, TNF-alpha, and IL-6 on the glomerular filtration barrier (GFB) in vivo. Reactive Oxygen Species 31-34 interleukin 1 beta Rattus norvegicus 57-65 26290366-8 2015 In conclusion IL-1beta, TNF-alpha, and IL-6, when infused systemically, caused immediate and partly reversible increases in glomerular permeability, which could be inhibited by the superoxide scavenger tempol, suggesting an important role of ROS in acute cytokine-induced permeability changes in the GFB. Superoxides 181-191 interleukin 1 beta Rattus norvegicus 14-22 26290366-8 2015 In conclusion IL-1beta, TNF-alpha, and IL-6, when infused systemically, caused immediate and partly reversible increases in glomerular permeability, which could be inhibited by the superoxide scavenger tempol, suggesting an important role of ROS in acute cytokine-induced permeability changes in the GFB. tempol 202-208 interleukin 1 beta Rattus norvegicus 14-22 26290366-8 2015 In conclusion IL-1beta, TNF-alpha, and IL-6, when infused systemically, caused immediate and partly reversible increases in glomerular permeability, which could be inhibited by the superoxide scavenger tempol, suggesting an important role of ROS in acute cytokine-induced permeability changes in the GFB. Reactive Oxygen Species 242-245 interleukin 1 beta Rattus norvegicus 14-22 26623013-0 2015 Tripterygium glycosides inhibit inflammatory mediators in the rat synovial RSC-364 cell line stimulated with interleukin-1beta. Glycosides 13-23 interleukin 1 beta Rattus norvegicus 109-126 26535078-7 2015 Treatment of simvastatin reduced the LPS-accelerated infarct size by 73%, and decreased the ischemia/reperfusion-induced expressions of pro-inflammatory mediators such as iNOS, COX-2 and IL-1beta in LPS-injected rat brains. Simvastatin 13-24 interleukin 1 beta Rattus norvegicus 187-195 26385354-7 2015 Sal also attenuated the pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in serum by inhibiting TLR4/NF-kappaB signaling pathway. rhodioloside 0-3 interleukin 1 beta Rattus norvegicus 102-124 26162710-2 2015 In the current study, which is based on a chronic morphine tolerance rat model and sustained morphine treatment on primary neuron culture, it was observed that Akt phosphorylation, cleaved-Caspase-1-dependent NALP1 inflammasome activation and IL-1beta maturation in spinal cord neurons were significantly enhanced by morphine. Morphine 50-58 interleukin 1 beta Rattus norvegicus 243-251 26162710-2 2015 In the current study, which is based on a chronic morphine tolerance rat model and sustained morphine treatment on primary neuron culture, it was observed that Akt phosphorylation, cleaved-Caspase-1-dependent NALP1 inflammasome activation and IL-1beta maturation in spinal cord neurons were significantly enhanced by morphine. Morphine 93-101 interleukin 1 beta Rattus norvegicus 243-251 26162710-2 2015 In the current study, which is based on a chronic morphine tolerance rat model and sustained morphine treatment on primary neuron culture, it was observed that Akt phosphorylation, cleaved-Caspase-1-dependent NALP1 inflammasome activation and IL-1beta maturation in spinal cord neurons were significantly enhanced by morphine. Morphine 93-101 interleukin 1 beta Rattus norvegicus 243-251 26162710-4 2015 Tail-flick tests demonstrated that pharmacological inhibition on Caspase-1 activation or antagonizing IL-1beta dramatically blocked the development of morphine tolerance. Morphine 151-159 interleukin 1 beta Rattus norvegicus 102-110 26162710-5 2015 The administration of an exogenous analogue of lipoxin, Aspirin-triggered Lipoxin (ATL), caused a decline in Caspase-1 cleavage, inflammasome activation and mature IL-1beta production and thus attenuated the development of morphine tolerance by inhibiting upstream Akt phosphorylation. Lipoxins 47-54 interleukin 1 beta Rattus norvegicus 164-172 26162710-5 2015 The administration of an exogenous analogue of lipoxin, Aspirin-triggered Lipoxin (ATL), caused a decline in Caspase-1 cleavage, inflammasome activation and mature IL-1beta production and thus attenuated the development of morphine tolerance by inhibiting upstream Akt phosphorylation. Aspirin 56-63 interleukin 1 beta Rattus norvegicus 164-172 26162710-5 2015 The administration of an exogenous analogue of lipoxin, Aspirin-triggered Lipoxin (ATL), caused a decline in Caspase-1 cleavage, inflammasome activation and mature IL-1beta production and thus attenuated the development of morphine tolerance by inhibiting upstream Akt phosphorylation. Lipoxins 74-81 interleukin 1 beta Rattus norvegicus 164-172 26138652-5 2015 NFkappaB activity and inflammatory cytokine expression, including serum levels of TNF-alpha, IL-1beta, and IL-6, increased in the MDP group compared to the controls; these effects were reversed by perfusion of the nutritional dipeptide Gly-Gly. Dipeptides 226-235 interleukin 1 beta Rattus norvegicus 93-101 27352344-7 2015 ELISA analysis data showed that both levels of IL-1beta and IL-6 produced by the stimulation of TNF-alpha were decreased by paeonol in a dose-dependent manner in VSMCs. paeonol 124-131 interleukin 1 beta Rattus norvegicus 47-55 26138652-5 2015 NFkappaB activity and inflammatory cytokine expression, including serum levels of TNF-alpha, IL-1beta, and IL-6, increased in the MDP group compared to the controls; these effects were reversed by perfusion of the nutritional dipeptide Gly-Gly. Glycylglycine 236-243 interleukin 1 beta Rattus norvegicus 93-101 25669660-5 2015 Moreover, l-carnitine accelerated reactive oxygen species production in serum and liver, thereby triggering hepatic NOD-like receptor 3 (NLRP3) inflammasome activation to elevate serum interleukin (IL)-1beta and IL-18 levels in rats. Carnitine 10-21 interleukin 1 beta Rattus norvegicus 185-207 26377490-6 2015 CONCLUSION: The renoprotective effect of sildenafil against renal I/R might be due to the activation of antioxidant genes (Nrf2, HO-1 and NQO-1) and antiapoptotic gene (Bcl2) and attenuation of proinflammatory cytokines (TNF-a, IL-1beta and ICAM-1). Sildenafil Citrate 41-51 interleukin 1 beta Rattus norvegicus 228-236 26485583-9 2015 The expression of TNF-alpha, IL-6, IL-1beta, CXCL-10, VCAM-1, and ICAM-1 were markedly decreased in the samples from the fucoidan-treated group. fucoidan 121-129 interleukin 1 beta Rattus norvegicus 35-43 26557015-8 2015 Real-time PCR results revealed that EGCG inhibited TBI-induced IL-1beta and TNF-alpha mRNA expression. epigallocatechin gallate 36-40 interleukin 1 beta Rattus norvegicus 63-71 25719309-9 2015 The mRNA expression of IL-1beta, IL-18, and TNF-alpha was significantly reduced in TQ-coadministered rats than that in EtOH- and HFD-fed rats. Ethanol 119-123 interleukin 1 beta Rattus norvegicus 23-31 26205746-0 2015 Exenatide and Sitagliptin Decrease Interleukin 1beta, Matrix Metalloproteinase 9, and Nitric Oxide Synthase 2 Gene Expression But Does Not Reduce Alveolar Bone Loss in Rats With Periodontitis. Sitagliptin Phosphate 14-25 interleukin 1 beta Rattus norvegicus 35-52 25269538-7 2015 Baicalin treatment also induced a significant decrease in the levels of inflammatory mediators, including the myeloperoxidase activity, the levels of tumor necrosis factor alpha, IL-1beta, and Th1-related cytokines IL-12 and IFN-gamma. baicalin 0-8 interleukin 1 beta Rattus norvegicus 179-187 26209154-9 2015 Additionally, caffeine treatment significantly reduced the d-galactose-induced neuroinflammation through alleviation of COX-2, NOS-2, TNFalpha and IL-1beta. Caffeine 14-22 interleukin 1 beta Rattus norvegicus 147-155 26209154-9 2015 Additionally, caffeine treatment significantly reduced the d-galactose-induced neuroinflammation through alleviation of COX-2, NOS-2, TNFalpha and IL-1beta. Galactose 59-70 interleukin 1 beta Rattus norvegicus 147-155 26475134-10 2015 Most importantly, inflammasome activation and IL-1beta/IL-18 release were significantly inhibited by ONOO(-) decomposition with FeTPPS. onoo 101-105 interleukin 1 beta Rattus norvegicus 46-54 26473731-4 2015 We have shown that A151, a synthetic oligodeoxynucleotide containing multiple telemeric TTAGGG motifs, reduces IL-1beta production by activated bone marrow derived macrophages that have been subjected to oxygen-glucose deprivation and LPS stimulation. Oligodeoxyribonucleotides 37-57 interleukin 1 beta Rattus norvegicus 111-119 26770320-7 2015 Moreover, dexmedetomidine significantly inhibited these TNF-alpha, IL-1beta, MDA, SOD and caspase-3 activities in isoflurane-induced aging rat. Dexmedetomidine 10-25 interleukin 1 beta Rattus norvegicus 67-75 26770320-7 2015 Moreover, dexmedetomidine significantly inhibited these TNF-alpha, IL-1beta, MDA, SOD and caspase-3 activities in isoflurane-induced aging rat. Isoflurane 114-124 interleukin 1 beta Rattus norvegicus 67-75 26469068-6 2015 Additionally, the BMSC-EVs injection resulted in a markedly decrease in interleukin-1beta (IL-1beta) and an increase in interleukin-10 (IL-10) expression. bmsc-evs 18-26 interleukin 1 beta Rattus norvegicus 72-89 26469068-6 2015 Additionally, the BMSC-EVs injection resulted in a markedly decrease in interleukin-1beta (IL-1beta) and an increase in interleukin-10 (IL-10) expression. bmsc-evs 18-26 interleukin 1 beta Rattus norvegicus 91-99 26101070-11 2015 The mRNA expression and protein levels of TNF-alpha, MMP-9 and IL-1beta were progressively and markedly reduced in deferoxamine-treated rats. Deferoxamine 115-127 interleukin 1 beta Rattus norvegicus 63-71 24812291-0 2015 Inadequate corticosterone levels relative to arthritic inflammation are accompanied by altered mitochondria/cholesterol breakdown in adrenal cortex: a steroid-inhibiting role of IL-1beta in rats. Steroids 151-158 interleukin 1 beta Rattus norvegicus 178-186 24812291-9 2015 IL-1beta inhibited ACTH-stimulated corticosterone secretion from adrenocortical cells in vitro. Corticosterone 35-49 interleukin 1 beta Rattus norvegicus 0-8 26511444-13 2015 Sildenafil treatment normalizes IL-1beta and TNF-alpha levels, p38 phosphorylation, and membrane expression of GABAA, AMPA, and NMDA receptors and restores spatial learning. Sildenafil Citrate 0-10 interleukin 1 beta Rattus norvegicus 32-40 26210617-13 2015 The ATX-mediated down-regulation of MMP-9 was correlated with the decreased levels of IL-1beta, TNF-alpha, oxidative stress, activated microglia and infiltrating neutrophils. astaxanthine 4-7 interleukin 1 beta Rattus norvegicus 86-94 26770373-5 2015 We found that sulforaphane significantly attenuated the blood-brain barrier (BBB) disruption; decreased the levels of pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta; reduced the nitric oxide (NO) levels and inducible nitric oxide synthase (iNOS) activity; inhibited the expression of iNOS and cyclooxygenase-2 (COX-2). sulforaphane 14-26 interleukin 1 beta Rattus norvegicus 183-205 26770491-6 2015 The results of detection of renal function and inflammatory factors showed that, comparing to group S, Scr, BUN, IL-1beta and TNF-alpha were all enhanced in group I/R, group Pre/Dex and group Post/Dex, significantly (P < 0.05), while the inflammatory factors in group Pre/Dex and group Post/Dex were lower than in group I/R, significantly (P < 0.05). Dexmedetomidine 197-200 interleukin 1 beta Rattus norvegicus 113-121 26770491-6 2015 The results of detection of renal function and inflammatory factors showed that, comparing to group S, Scr, BUN, IL-1beta and TNF-alpha were all enhanced in group I/R, group Pre/Dex and group Post/Dex, significantly (P < 0.05), while the inflammatory factors in group Pre/Dex and group Post/Dex were lower than in group I/R, significantly (P < 0.05). Dexmedetomidine 197-200 interleukin 1 beta Rattus norvegicus 113-121 26770491-6 2015 The results of detection of renal function and inflammatory factors showed that, comparing to group S, Scr, BUN, IL-1beta and TNF-alpha were all enhanced in group I/R, group Pre/Dex and group Post/Dex, significantly (P < 0.05), while the inflammatory factors in group Pre/Dex and group Post/Dex were lower than in group I/R, significantly (P < 0.05). Dexmedetomidine 197-200 interleukin 1 beta Rattus norvegicus 113-121 26043968-11 2015 In summary, restoration of the analgesic activity of morphine and buprenorphine by blockade of IL-1 signaling suggests that increased IL-1beta responses may account for the decreased analgesic efficacy of opioids observed in the treatment of neuropathy. Morphine 53-61 interleukin 1 beta Rattus norvegicus 134-142 26043968-11 2015 In summary, restoration of the analgesic activity of morphine and buprenorphine by blockade of IL-1 signaling suggests that increased IL-1beta responses may account for the decreased analgesic efficacy of opioids observed in the treatment of neuropathy. Buprenorphine 66-79 interleukin 1 beta Rattus norvegicus 134-142 26297952-7 2015 Quercetin lowered levels of interleukin-1beta, C-reactive protein, and monocyte chemotactic protein-1 and restored plasma antioxidant capacity. Quercetin 0-9 interleukin 1 beta Rattus norvegicus 28-45 25820467-9 2015 We found that H2 clearly inhibited hyperalgesia and allodynia in neuropathic pain and also attenuated the pro-inflammatory cytokines TNF-alpha, IL-1beta, and high-mobility group box (HMGB) 1. Hydrogen 14-16 interleukin 1 beta Rattus norvegicus 144-152 26469753-6 2015 RESULTS: Treatment with doxycycline dramatically reduced the clinical scores of EIU (P < 0.001), with significant decreases in inflammatory cell infiltration, protein concentrations, and the production of NO, TNF-alpha, and IL-1beta in the aqueous humor (AqH). Doxycycline 24-35 interleukin 1 beta Rattus norvegicus 227-235 26469753-7 2015 In vitro, doxycycline significantly inhibited the production of NO, IL-1beta, and TNF-alpha in peritoneal macrophages by modulating the PI3K/Akt/IkappaB-alpha/NF-kappaB pathway. Doxycycline 10-21 interleukin 1 beta Rattus norvegicus 68-76 26516581-10 2015 DEX inhibited the expressions of IL-1beta, IL-6, and RANKL, but did not alter OPG. Dexamethasone 0-3 interleukin 1 beta Rattus norvegicus 33-41 25917538-5 2015 The results demonstrated that the inflammatory process caused by the administration of CG into the pleural cavity resulted in a substantial increase in the levels of tumor necrosis factor-alpha, interleukin-1beta, and myeloperoxidase and a reduction in interleukin-10 levels. Carrageenan 87-89 interleukin 1 beta Rattus norvegicus 195-212 26239160-0 2015 Roles of microRNA-146a and microRNA-181b in regulating the secretion of tumor necrosis factor-alpha and interleukin-1beta in silicon dioxide-induced NR8383 rat macrophages. Silicon Dioxide 125-140 interleukin 1 beta Rattus norvegicus 104-121 26239160-2 2015 Therefore, the present study examined the roles of miR-146a and miR-181b in inflammatory responses, and their effect on the expression of the tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) inflammatory chemokines in silicon dioxide (SiO2)-induced NR8383 rat macrophages. Silicon Dioxide 242-257 interleukin 1 beta Rattus norvegicus 205-213 26239160-2 2015 Therefore, the present study examined the roles of miR-146a and miR-181b in inflammatory responses, and their effect on the expression of the tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) inflammatory chemokines in silicon dioxide (SiO2)-induced NR8383 rat macrophages. Silicon Dioxide 259-263 interleukin 1 beta Rattus norvegicus 205-213 26239160-8 2015 It was observed that, following treatment of the NR8383 cells with SiO2 for 12 h, the levels of TNF-alpha were significantly increased following miR-181b knockdown and the levels of IL-1beta were significantly increased following miR-146a knockdown, compared with the inhibitor-treated controls (P<0.05). Silicon Dioxide 67-71 interleukin 1 beta Rattus norvegicus 182-190 26348276-6 2015 Mechanistic studies showed that dioscin significantly increased HSP70 levels, decreased the levels of TLR4, MyD88, TRAF6, COX-2, JNK, ERK and p38 MAPK phosphorylation, suppressed the nuclear translocation of NF-kappaB and HMGB1, and subsequently decreased the mRNA levels of IL-1beta, IL-6, TNF-alpha, ICAM-1 and IFN-gamma. dioscin 32-39 interleukin 1 beta Rattus norvegicus 275-283 26330101-7 2015 We found that H2O2 stimulated the production of IL-6, IL-1beta, TNF-alpha and NO, which could be reduced by pretreatment with FA through inhibiting the p-NF-kappaB as well as the iNOS expression. Hydrogen Peroxide 14-18 interleukin 1 beta Rattus norvegicus 54-62 26426693-11 2015 Moreover, PD98059 also prevented increase of pro- (IL-1beta, IL-6, and iNOS) but enhances anti-nociceptive (IL-10) factors. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 10-17 interleukin 1 beta Rattus norvegicus 51-59 25919765-11 2015 The I/R-induced increases of hepatic interferon-gamma, tumor necrosis factor-alpha and IL-1beta expression, and neutrophil infiltration were also significantly reduced by remifentanil. Remifentanil 171-183 interleukin 1 beta Rattus norvegicus 87-95 26547344-5 2015 Dex pretreatment obviously lowered IL-1beta and MDA levels and enhanced SOD activity in the plasma and renal tissues in LPS-challenged rats (P<0.05), and significantly lessened LPS-induced renal pathologies. Dexmedetomidine 0-3 interleukin 1 beta Rattus norvegicus 35-43 26827495-6 2015 Because diclofenac is a non-specific antagonist of cyclooxygenases, it had been concluded that the prostaglandins mediate respiratory effects of IL-1beta in point of fact. Diclofenac 8-18 interleukin 1 beta Rattus norvegicus 145-153 26827495-6 2015 Because diclofenac is a non-specific antagonist of cyclooxygenases, it had been concluded that the prostaglandins mediate respiratory effects of IL-1beta in point of fact. Prostaglandins 99-113 interleukin 1 beta Rattus norvegicus 145-153 26727788-7 2015 RESULTS: Compared with the model control group, the femur BMD was increased, while IL-1beta, IL-6 and TNF-alpha were all decreased in zoledronate sodium group; the serum TRACP5b and CTX-I level were both reduced in zoledronate sodium group. zoledronate sodium 134-152 interleukin 1 beta Rattus norvegicus 83-91 26727788-8 2015 CONCLUSION: The zoledronate sodium could effectively inhibit periprosthetic osteolysis in rats induced by polyethylene particles, which might be realized by inhibiting the activity of osteoclasts and the expression of IL-1beta, IL-6 and TNF-alpha. zoledronate sodium 16-34 interleukin 1 beta Rattus norvegicus 218-226 26727788-8 2015 CONCLUSION: The zoledronate sodium could effectively inhibit periprosthetic osteolysis in rats induced by polyethylene particles, which might be realized by inhibiting the activity of osteoclasts and the expression of IL-1beta, IL-6 and TNF-alpha. Polyethylene 106-118 interleukin 1 beta Rattus norvegicus 218-226 26403947-7 2015 Furthermore, nicorandil significantly alleviated oxidative stress (as determined by lipid peroxides and reduced glutathione levels and total antioxidant capacity), as well as inflammatory markers (tumour necrosis factor-alpha and interleukin-1beta), in bronchoalveolar lavage fluid and testicular tissue. Nicorandil 13-23 interleukin 1 beta Rattus norvegicus 230-247 27132443-7 2015 (2) ACh with the final concentrations of 0.01, 0.1, and 1 mumol/L had less influence on the production of TNF-alpha, IL-1beta and IL-6 in the culture supernatants of alveolar macrophages stimulated with LPS compared with LPS group (all P > 0.05). Acetylcholine 4-7 interleukin 1 beta Rattus norvegicus 117-125 26282205-3 2015 We previously reported that the suppression of ACSL4 activity by treatment with an ACSL inhibitor or a small interfering RNA markedly enhanced interleukin-1beta (IL-1beta)-dependent prostaglandin (PG) biosynthesis in rat fibroblastic 3Y1 cells. Prostaglandins 182-195 interleukin 1 beta Rattus norvegicus 143-160 26282205-3 2015 We previously reported that the suppression of ACSL4 activity by treatment with an ACSL inhibitor or a small interfering RNA markedly enhanced interleukin-1beta (IL-1beta)-dependent prostaglandin (PG) biosynthesis in rat fibroblastic 3Y1 cells. Prostaglandins 182-195 interleukin 1 beta Rattus norvegicus 162-170 26282205-3 2015 We previously reported that the suppression of ACSL4 activity by treatment with an ACSL inhibitor or a small interfering RNA markedly enhanced interleukin-1beta (IL-1beta)-dependent prostaglandin (PG) biosynthesis in rat fibroblastic 3Y1 cells. Prostaglandins 197-199 interleukin 1 beta Rattus norvegicus 143-160 26282205-3 2015 We previously reported that the suppression of ACSL4 activity by treatment with an ACSL inhibitor or a small interfering RNA markedly enhanced interleukin-1beta (IL-1beta)-dependent prostaglandin (PG) biosynthesis in rat fibroblastic 3Y1 cells. Prostaglandins 197-199 interleukin 1 beta Rattus norvegicus 162-170 26282205-5 2015 Treatment of several types of cells with an ACSL inhibitor, triacsin C, markedly enhanced IL-1beta-dependent production of 5,11-diHETE. triacsin C 60-70 interleukin 1 beta Rattus norvegicus 90-98 26394827-3 2015 RESULTS: Co-administration of the pioglitazone with morphine not only attenuated morphine-induced tolerance, but also prevented the up-regulation of pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin-1beta, and interleukin 6) and nuclear factor-kappa B activity. Pioglitazone 34-46 interleukin 1 beta Rattus norvegicus 206-223 26282205-5 2015 Treatment of several types of cells with an ACSL inhibitor, triacsin C, markedly enhanced IL-1beta-dependent production of 5,11-diHETE. 5,11-diHETE 123-134 interleukin 1 beta Rattus norvegicus 90-98 26282205-6 2015 siRNA-mediated knockdown of ACSL4 also enhanced IL-1beta-dependent production of 5,11-diHETE from 3Y1 cells. 5,11-diHETE 81-92 interleukin 1 beta Rattus norvegicus 48-56 26394827-3 2015 RESULTS: Co-administration of the pioglitazone with morphine not only attenuated morphine-induced tolerance, but also prevented the up-regulation of pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin-1beta, and interleukin 6) and nuclear factor-kappa B activity. Morphine 52-60 interleukin 1 beta Rattus norvegicus 206-223 26188590-5 2015 KEY FINDINGS: Fructose fed rats had hyperinsulinemia, hypertriglyceridemia, higher HOMA-IR, IGR and lower Matsuda indices compared to control animals, together with increased oxidative stress markers, TNFalpha, IL1beta and PAI-1 gene expression, and TNFalpha and COX-2 protein content. Fructose 14-22 interleukin 1 beta Rattus norvegicus 211-218 26259694-3 2015 We found that acute nicotine injection markedly attenuated LPS-elicited cognitive deficits and suppressed the strong LPS-induced release of IL-1beta, IL-6, and TNF-alpha into serum and the dorsal hippocampus at 4 and 24h after LPS injection. Nicotine 20-28 interleukin 1 beta Rattus norvegicus 140-148 26370989-0 2015 Tetramethylpyrazine Protects Retinal Capillary Endothelial Cells (TR-iBRB2) against IL-1beta-Induced Nitrative/Oxidative Stress. tetramethylpyrazine 0-19 interleukin 1 beta Rattus norvegicus 84-92 25979673-6 2015 Sevoflurane preconditioning significantly dose-dependently reduced MDA, IL-1beta, IL-6, IL-10 and TNF-alpha levels and enhanced antioxidant enzyme activities in hippocampus tissue of CIR+SP groups compared to CIR group. Sevoflurane 0-11 interleukin 1 beta Rattus norvegicus 72-80 25979673-6 2015 Sevoflurane preconditioning significantly dose-dependently reduced MDA, IL-1beta, IL-6, IL-10 and TNF-alpha levels and enhanced antioxidant enzyme activities in hippocampus tissue of CIR+SP groups compared to CIR group. Citrulline 183-186 interleukin 1 beta Rattus norvegicus 72-80 26354875-8 2015 Meanwhile, rhein reduced ATP/BzATP-induced IL-1beta release in lipopolysaccharide-activated macrophages. Adenosine Triphosphate 25-28 interleukin 1 beta Rattus norvegicus 43-51 26354875-8 2015 Meanwhile, rhein reduced ATP/BzATP-induced IL-1beta release in lipopolysaccharide-activated macrophages. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 29-34 interleukin 1 beta Rattus norvegicus 43-51 26354875-11 2015 Together, our results demonstrate that rhein inhibit ATP/BzATP-induced [Ca(2+)]c increase, pore formation, ROS production, phagocytosis attenuation, IL-1beta release and cell apoptosis by antagonizing the P2X7 receptor in rat peritoneal macrophages. Adenosine Triphosphate 53-56 interleukin 1 beta Rattus norvegicus 149-157 26354875-11 2015 Together, our results demonstrate that rhein inhibit ATP/BzATP-induced [Ca(2+)]c increase, pore formation, ROS production, phagocytosis attenuation, IL-1beta release and cell apoptosis by antagonizing the P2X7 receptor in rat peritoneal macrophages. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 57-62 interleukin 1 beta Rattus norvegicus 149-157 26370989-3 2015 In the present study, we investigated the protective effect of tetramethylpyrazine (TMP), a major active component of the traditional herb Ligusticum chuanxiong, on IL-1beta-induced cell death of the rat retinal capillary endothelial TR-iBRB2 cells. tetramethylpyrazine 63-82 interleukin 1 beta Rattus norvegicus 165-173 26370989-3 2015 In the present study, we investigated the protective effect of tetramethylpyrazine (TMP), a major active component of the traditional herb Ligusticum chuanxiong, on IL-1beta-induced cell death of the rat retinal capillary endothelial TR-iBRB2 cells. tetramethylpyrazine 84-87 interleukin 1 beta Rattus norvegicus 165-173 26370989-4 2015 Our results showed that IL-1beta-induced cell dysfunction in TR-iBRB2 cells via inducing nitrative/oxidative stress; however, such effect was attenuated with the pre-treatment of TMP. tetramethylpyrazine 179-182 interleukin 1 beta Rattus norvegicus 24-32 26283592-6 2015 The total intracellular nitric oxide level induced by both interleukin 1beta and stretching is balanced by interleukin-1beta induced cation influx. Nitric Oxide 24-36 interleukin 1 beta Rattus norvegicus 107-124 26112336-11 2015 The brain measures of IL-1beta, IL-6 and TNF-alpha in TBI were also reduced by estrogen. Thioacetazone 54-57 interleukin 1 beta Rattus norvegicus 22-30 26283592-6 2015 The total intracellular nitric oxide level induced by both interleukin 1beta and stretching is balanced by interleukin-1beta induced cation influx. Nitric Oxide 24-36 interleukin 1 beta Rattus norvegicus 59-76 26389948-7 2015 Retinal gene expression of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, vascular endothelial growth factor, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 were all decreased in ZZRext-treated diabetic rats. zzrext 216-222 interleukin 1 beta Rattus norvegicus 56-78 26051590-3 2015 Cadmium consumption resulted in reduction of bacteria corresponding to Lactobacillus strain, tissue damage and intestinal inflammation [increases in high mobility group box 1 (HMGB1 molecules), superoxide dismutase (SOD) and catalase (CAT) activity and proinflammatory cytokine (TNF, IL-1beta, IFN-gamma, IL-17) content]. Cadmium 0-7 interleukin 1 beta Rattus norvegicus 284-292 25880347-7 2015 KEY FINDINGS: The levels of ROS and inflammatory cytokine including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6 and IL-8 in H9c2 cells were increased remarkably by hypoxia. Reactive Oxygen Species 28-31 interleukin 1 beta Rattus norvegicus 103-125 26218407-7 2015 The levels of interleukin-1 beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha) in the lungs increased after injection of neutral fat and oleic acid. Oleic Acid 152-162 interleukin 1 beta Rattus norvegicus 14-32 26218407-7 2015 The levels of interleukin-1 beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha) in the lungs increased after injection of neutral fat and oleic acid. Oleic Acid 152-162 interleukin 1 beta Rattus norvegicus 34-42 26218407-11 2015 After injection of oleic acid, peak levels of IL-1beta, IL-6, and TNF-alpha were detected at 6h, and IL-6 again increased in all organs and plasma at 15h. Oleic Acid 19-29 interleukin 1 beta Rattus norvegicus 46-54 26196303-6 2015 Salicylate and AICAR reduced TXNIP induction and inhibited NLRP3 inflammasome activation by reducing NLRP3 and caspase-1 expression, leading to a reduction in IL-1beta secretion. Salicylates 0-10 interleukin 1 beta Rattus norvegicus 159-167 26188182-9 2015 Ligustrazine decreased the levels of IL-1beta, IL-6, TNF-alpha in blood serum and the expression of TGF-beta1, CTGF in the peritoneal fluid in dose-dependent manner. tetramethylpyrazine 0-12 interleukin 1 beta Rattus norvegicus 37-45 26016627-8 2015 In vitro experiment showed that propofol pre-treatment inhibited ATP-induced microglial activation and release of tumor necrosis factor-alpha and interleukin-1beta. Propofol 32-40 interleukin 1 beta Rattus norvegicus 146-163 26016627-8 2015 In vitro experiment showed that propofol pre-treatment inhibited ATP-induced microglial activation and release of tumor necrosis factor-alpha and interleukin-1beta. Adenosine Triphosphate 65-68 interleukin 1 beta Rattus norvegicus 146-163 26116164-8 2015 Using immunohistochemistry, ELISA, RT-PCR, Western blot method to explore the protective effect and mechanism of gentiopicroside on chondrocytes induced by IL-1beta. gentiopicroside 113-128 interleukin 1 beta Rattus norvegicus 156-164 26032330-4 2015 In the saline-treated I/R group, the increased serum interleukin (IL)-1beta level, high damage scores, and elevated tissue malondialdehyde level and collagen content in both tissues were significantly reduced by obestatin or ghrelin. Sodium Chloride 7-13 interleukin 1 beta Rattus norvegicus 53-75 26032330-4 2015 In the saline-treated I/R group, the increased serum interleukin (IL)-1beta level, high damage scores, and elevated tissue malondialdehyde level and collagen content in both tissues were significantly reduced by obestatin or ghrelin. Ghrelin 225-232 interleukin 1 beta Rattus norvegicus 53-75 26035555-7 2015 PF was able to significantly decrease the myocardial infarct size as well as the activities of creatine kinase (CK), the MB isoenzyme of CK, lactate dehydrogenase and cardiac troponin T. In addition, in the PF-treated groups, the expression levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and nuclear factor-kappaB were markedly inhibited. peoniflorin 0-2 interleukin 1 beta Rattus norvegicus 280-302 25989747-7 2015 Moreover, TA pretreatment contributed to the decrease in ratio of Bax/Bcl-2, as well as reduced expression of TNF-alpha, IL-1beta, caspase-3, cleaved-caspase-3 and -9. Tannins 10-12 interleukin 1 beta Rattus norvegicus 121-129 26182882-5 2015 In addition, both expression and secretion of inflammatory factor IL-1beta was inhibited in DAPT-pretreated astrocytes, while no significant change in TNF-alpha expression was detected. dapt 92-96 interleukin 1 beta Rattus norvegicus 66-74 26345159-2 2015 Curcumin (CM), a yellow hydrophobic polyphenol derived from the herb turmeric, has various pharmacological activities against many chronic diseases and acts by inhibiting cell proliferation and metastasis and downregulating various factors, including nuclear factor kappa B, interleukin-1beta and TNF-alpha. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 275-292 26116164-0 2015 Gentiopicroside prevents interleukin-1 beta induced inflammation response in rat articular chondrocyte. gentiopicroside 0-15 interleukin 1 beta Rattus norvegicus 25-43 26116164-6 2015 Western blotting, reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry were utilized to explore the protective effects and mechanisms of gentiopicroside prevents interleukin-1 beta induced inflammation response in rat articular chondrocyte. gentiopicroside 166-181 interleukin 1 beta Rattus norvegicus 191-209 26116164-9 2015 The results showed some pathways of IL-1beta signal transduction were inhibited by gentiopicroside in rat chondrocytes: p38, ERK and JNK. gentiopicroside 83-98 interleukin 1 beta Rattus norvegicus 36-44 26116164-10 2015 Meanwhile, gentiopicroside showed inhibition in the IL-1beta-induced release of MMPs while increasing Collagen type II expression. gentiopicroside 11-26 interleukin 1 beta Rattus norvegicus 52-60 26116164-11 2015 CONCLUSIONS: The current study demonstrated that gentiopicroside exhibited a potent protective effect on IL-1beta induced inflammation response in rat articular chondrocyte. gentiopicroside 49-64 interleukin 1 beta Rattus norvegicus 105-113 26117533-11 2015 Furthermore, Simiao pill up-regulated Sirt1 protein levels and suppressed NF-kappaB/NLRP3 inflammasome activation to reduce IL-1beta in renal glomeruli of high fructose-fed rats. Fructose 160-168 interleukin 1 beta Rattus norvegicus 124-132 26550330-10 2015 There was significant increase in tissue MDA, MPO activity, TNF-alpha and IL-1beta (P<0.05) and significant decrease in tissue GSH and histopathology (P<0.05) after Mtx administration. Methotrexate 171-174 interleukin 1 beta Rattus norvegicus 74-82 26135545-6 2015 A further analysis was undertaken to investigate the contribution of SGCs; the expression of interleukin-1beta (IL-1beta) in SGCs and interleukin-1 receptor I (IL-1RI) in neurons was significantly increased after chronic restraint stress, whereas injection of L-alpha-aminoadipate (a SGC inhibitor, LAA) into the TG dramatically inhibited the overexpression of these proteins. 2-Aminoadipic Acid 260-280 interleukin 1 beta Rattus norvegicus 112-120 26141610-6 2015 Moreover, we also tested the hypothesis that an inflammatory stimulus (interleukin-1beta) could exacerbate the effects induced by exposure to elevated glucose, contributing for changes in synaptic proteins in retinal neurons. Glucose 151-158 interleukin 1 beta Rattus norvegicus 71-88 26839527-9 2015 In addition, sesamol increased mean arterial pressure and IL-10, inhibited TNF-alpha and IL-1beta, but did not affect nitrite production in LPS-induced hypotension. sesamol 13-20 interleukin 1 beta Rattus norvegicus 89-97 26345937-6 2015 Midazolam significantly suppressed the IL-1beta-induced release of IL-6 in rat C6 glioma cells. Midazolam 0-9 interleukin 1 beta Rattus norvegicus 39-47 26262605-8 2015 Tumor necrosis factor alpha (TNF-alpha), interleukin (IL-1beta) and vascular endothelial growth factor (VEGF) were significantly reduced in diabetic rats treated with EAE, compared with untreated diabetic rats. EAE 167-170 interleukin 1 beta Rattus norvegicus 54-62 26839527-8 2015 Sesamol significantly inhibited BUN, CRE, IL-1beta, IL-6, and nitrite after CLP-induced acute renal injury. sesamol 0-7 interleukin 1 beta Rattus norvegicus 42-50 26260484-7 2015 Microglial interleukin-1beta over-expression in Vc was induced by trapezius muscle inflammation, which was significantly suppressed by SB203580 administration. SB 203580 135-143 interleukin 1 beta Rattus norvegicus 11-28 26044583-13 2015 Ticagrelor, but not clopidogrel, attenuated the increase in proinflammatory tumor necrosis factor-alpha, interleukin-1beta, and interleukin-18, and increased anti-inflammatory 15-epi-lipoxin-A4 levels. Ticagrelor 0-10 interleukin 1 beta Rattus norvegicus 105-122 26248290-13 2015 Furthermore, the content of IL-1beta, IL-2, IFN-gamma, TNF-alpha in serum and cerebral cortex were significantly decreased in 1.0 and 3.0 mg/kg rapamycin-treated rats. Sirolimus 144-153 interleukin 1 beta Rattus norvegicus 28-36 25989136-0 2015 IL-1beta reduces tonic contraction of mesenteric lymphatic muscle cells, with the involvement of cycloxygenase-2 and prostaglandin E2. Dinoprostone 117-133 interleukin 1 beta Rattus norvegicus 0-8 25989136-9 2015 IL-1beta increased COX-2 protein and PGE2 production in RMLMC.. PGE2 induced relaxations in RMLMC, comparable to h-IL-1beta. Dinoprostone 37-41 interleukin 1 beta Rattus norvegicus 0-8 25989136-9 2015 IL-1beta increased COX-2 protein and PGE2 production in RMLMC.. PGE2 induced relaxations in RMLMC, comparable to h-IL-1beta. Dinoprostone 64-68 interleukin 1 beta Rattus norvegicus 0-8 25989136-11 2015 CONCLUSIONS AND IMPLICATIONS: The IL-1beta-induced decrease in RMLMC tonic contraction was COX-2 dependent, and mediated by PGE2 . Dinoprostone 124-128 interleukin 1 beta Rattus norvegicus 34-42 25989136-12 2015 In experimental colitis, IL-1beta and tonic lymphatic contractility were causally related, as this cytokine was critical for the relaxation induced by AC-CM and pharmacological blockade of IL-1beta restored tonic contraction. ac-cm 151-156 interleukin 1 beta Rattus norvegicus 25-33 25989136-12 2015 In experimental colitis, IL-1beta and tonic lymphatic contractility were causally related, as this cytokine was critical for the relaxation induced by AC-CM and pharmacological blockade of IL-1beta restored tonic contraction. ac-cm 151-156 interleukin 1 beta Rattus norvegicus 189-197 25912457-9 2015 Using invasion chambers, interleukin-1beta (IL-1beta) stimulated by 5-fold the invasiveness of F98 cells, but this stimulation was completely inhibited by meloxicam. Meloxicam 155-164 interleukin 1 beta Rattus norvegicus 25-42 26397829-5 2015 BDNF levels in the rat"s prefrontal cortex were decreased at 1 h and 24 h after the last administration of ketamine, whereas the group administered with ketamine and omega-3 showed a decrease in BDNF levels only after 24 h. In contrast, both interventions induced similar responses in levels of IL-1beta and IL6. Ketamine 153-161 interleukin 1 beta Rattus norvegicus 295-303 26397829-6 2015 These findings suggest that the similarity of IL-1beta and IL6 levels in our experimental groups is due to the mechanism of action of ketamine on the immune system. Ketamine 134-142 interleukin 1 beta Rattus norvegicus 46-54 26464617-15 2015 Resveratrol also significantly modulated mRNA and protein levels by down-regulating NALP3 and Caspase1 expression and IL-1beta and IL-18 activation. Resveratrol 0-11 interleukin 1 beta Rattus norvegicus 118-126 26222320-8 2015 The brain tissue levels of IL-1beta, IL-6, and TNF-alpha were significantly reduced (p < 0.001) in the group treated with GA. Gallium 125-127 interleukin 1 beta Rattus norvegicus 27-35 25687637-9 2015 The expressions of MMP-1 and MMP-13 were significantly downregulated after PQQ treatment compared with that in IL-1beta alone group. PQQ Cofactor 75-78 interleukin 1 beta Rattus norvegicus 111-119 25687638-5 2015 The results showed that, as compared with a single treatment of CLX or DC, CLX combined with DC markedly attenuated OA and inhibited the levels of inflammatory mediators interleukin-1beta and nitric oxide, improved bone cartilage metabolism, and suppressed chondrocyte apoptosis. Celecoxib 75-78 interleukin 1 beta Rattus norvegicus 170-187 25912457-9 2015 Using invasion chambers, interleukin-1beta (IL-1beta) stimulated by 5-fold the invasiveness of F98 cells, but this stimulation was completely inhibited by meloxicam. Meloxicam 155-164 interleukin 1 beta Rattus norvegicus 44-52 26122117-11 2015 RESULTS: EGCG pretreatment can significantly reduce renal dysfunction, histologic change and the expression of tumor necrosis factor-alpha, IL-1beta, IL-6, Bax and cleavage caspase 3 induced by I/R injury and increase the expression of Bax and caspase 3. epigallocatechin gallate 9-13 interleukin 1 beta Rattus norvegicus 140-148 26080623-11 2015 Furthermore, the increase in the expression of STAT6 and p-STAT6 induced by cisplatin was reversed by treatment with TSA, accompanied by the decreased expression of IL-1beta, IL-4 and IL-6. Cisplatin 76-85 interleukin 1 beta Rattus norvegicus 165-173 26080623-11 2015 Furthermore, the increase in the expression of STAT6 and p-STAT6 induced by cisplatin was reversed by treatment with TSA, accompanied by the decreased expression of IL-1beta, IL-4 and IL-6. trichostatin A 117-120 interleukin 1 beta Rattus norvegicus 165-173 25891824-8 2015 Compared with the vehicle treated-SE group, pretreatment with pioglitazone was associated with the loss of fewer neurons, lower levels of IL-1beta and IL-6, and inhibition of the activation of the mTOR signaling pathway. Pioglitazone 62-74 interleukin 1 beta Rattus norvegicus 138-146 25774002-8 2015 Interestingly, posttreatment of SB significantly decreased the expression of alpha-smooth muscle actin, interleukin-1beta, inducible nitric oxide synthase, and 3-nitrotyrosine. Butyric Acid 32-34 interleukin 1 beta Rattus norvegicus 104-121 25944087-8 2015 Curcumin also reduced the inflammatory cell infiltration and myocardial mRNA levels of interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS). Curcumin 0-8 interleukin 1 beta Rattus norvegicus 87-104 25944087-8 2015 Curcumin also reduced the inflammatory cell infiltration and myocardial mRNA levels of interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS). Curcumin 0-8 interleukin 1 beta Rattus norvegicus 106-114 25976855-9 2015 RESULTS: Phospholipids reduced intra-abdominal adhesions (P < 0.001), with respect to their intensity and area, and serum levels of cytokines (interleukin 1beta, interleukin 6, platelet-derived growth factor-1, and TGFbeta1) compared with placebo-treated rats. Phospholipids 9-22 interleukin 1 beta Rattus norvegicus 146-163 25128027-9 2015 XQ-1H alleviated LPS-induced inflammatory response in rBMECs, characterized by promoting cell viability, inhibiting TNF-alpha, IL-1beta, and IL-6 releasing, and downregulating NF-kappaB inflammatory signal and downstream proteins, such as VCAM-1 and iNOS. xq-1h 0-5 interleukin 1 beta Rattus norvegicus 127-135 25872478-11 2015 Following the induction of cerebral trauma, CQ treatment significantly suppressed neuronal autophagy and reduced expression levels of the inflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), in the rat hippocampus. Chloroquine 44-46 interleukin 1 beta Rattus norvegicus 162-179 25872478-11 2015 Following the induction of cerebral trauma, CQ treatment significantly suppressed neuronal autophagy and reduced expression levels of the inflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), in the rat hippocampus. Chloroquine 44-46 interleukin 1 beta Rattus norvegicus 181-189 25873133-10 2015 Following trauma, BBG treatment significantly reduced the levels of PKCgamma and interleukin-1beta in the cortex. coomassie Brilliant Blue 18-21 interleukin 1 beta Rattus norvegicus 81-98 25873133-11 2015 The results provide in vivo evidence that BBG exerted neuroprotective effects by attenuating brain edema and improving neurological functions via reducing PKCgamma and interleukin-1beta levels following TBI. coomassie Brilliant Blue 42-45 interleukin 1 beta Rattus norvegicus 168-185 25159478-0 2015 IL-1beta Induces MMP-9-Dependent Brain Astrocytic Migration via Transactivation of PDGF Receptor/NADPH Oxidase 2-Derived Reactive Oxygen Species Signals. Reactive Oxygen Species 121-144 interleukin 1 beta Rattus norvegicus 0-8 25159478-7 2015 Next, IL-1beta-induced MMP-9 expression is mediated through a c-Src-mediated transactivation of PDGFR/PI3K/Akt cascade linking to p47(phox)/NADPH oxidase 2 (Nox2)/ROS signaling pathway. Reactive Oxygen Species 163-166 interleukin 1 beta Rattus norvegicus 6-14 25159478-10 2015 These results demonstrated that in RBA-1 cells, activation of NF-kappaB and AP-1 (ATF2) by the c-Src/PDGFR/PI3K/Akt-mediated Nox2/ROS/MAPKs signals is required for upregulation of MMP-9 and cell migration enhanced by IL-1beta. Reactive Oxygen Species 130-133 interleukin 1 beta Rattus norvegicus 217-225 25936382-9 2015 Iptakalim also prevented an increase in IL-1beta and a decrease in IL-10 in the peripheral blood and lung tissue, and alleviated inflammatory cell infiltration in hypoxia-induced PAH rats. N-(1-methylethyl)-1,1,2-trimethylpropylamine 0-9 interleukin 1 beta Rattus norvegicus 40-48 25891824-9 2015 Therefore, the mTOR signaling pathway was activated in the PTZ-induced SE rat model, and the PPAR-gamma agonist, pioglitazone, had a neuroprotective effect, by inhibiting activation of the mTOR pathway and preventing the increase in the levels of IL-1beta and IL-6. Pioglitazone 113-125 interleukin 1 beta Rattus norvegicus 247-255 26160706-4 2015 Administration of 3-NP (10 mg/kg for 21 days) showed loss in body weight, declined motor function and changes in biochemical (LPO, nitrite and glutathione level), neuroinflammatory (TNF-alpha and IL-1beta level) and neurochemical (DA, NE, 5-HT, DOPAC, 5-HIAA and HVA). 3-nitropropionic acid 18-22 interleukin 1 beta Rattus norvegicus 196-204 26198193-9 2015 The inflammation-related molecules TNF-alpha, IL-1beta, IL-6 levels usually caused by ischemia/reperfusion were significantly ameliorated by EGCG. epigallocatechin gallate 141-145 interleukin 1 beta Rattus norvegicus 46-54 25955348-10 2015 However, TNF-alpha, IL-1beta and iNOS expression levels were higher in rats with STZ-induced diabetes compared with control rats. Streptozocin 81-84 interleukin 1 beta Rattus norvegicus 20-28 25797150-8 2015 Levels of TNF-alpha, IL-6 and IL-1beta in the hippocampal homogenates were significantly increased in sedentary ZDF rats compared to sedentary ZLC rats, respectively. zdf 112-115 interleukin 1 beta Rattus norvegicus 30-38 25797150-9 2015 However, TNF-alpha, IL-6 and IL-1beta levels in the exercised ZDF rats were significantly decreased compared with those of sedentary ZDF rats, respectively. zdf 62-65 interleukin 1 beta Rattus norvegicus 29-37 26224622-8 2015 Furthermore, blocking TLR4 by eritoran (TLR4 antagonist) in TGs of the AP model significantly down-regulated MyD88, TRIF, NF-kappaB, TNF-alpha and IL-1beta production and behavior of nociceptive response. eritoran 30-38 interleukin 1 beta Rattus norvegicus 147-155 26983232-4 2015 RESULTS: Morinda processed by salt and n-BuOH extract could reduce paw swelling and levels of TNF-alpha, IL-1beta, IL-6 and INF-gamma in AA rats serum, which followed by morinda EtOAc extract. Salts 30-34 interleukin 1 beta Rattus norvegicus 105-113 26983232-4 2015 RESULTS: Morinda processed by salt and n-BuOH extract could reduce paw swelling and levels of TNF-alpha, IL-1beta, IL-6 and INF-gamma in AA rats serum, which followed by morinda EtOAc extract. Butanols 39-45 interleukin 1 beta Rattus norvegicus 105-113 25955429-11 2015 The rats with SP presented with a shorter refractoriness, a higher incidence and duration of AF, an enhanced susceptibility to developing AF, increased mRNA levels of AF-related pro-inflammatory cytokines (IL-6, IL-1beta and TGF-beta1), as well as marked atrial inflammation and fibrosis. sp 14-16 interleukin 1 beta Rattus norvegicus 212-220 26045616-10 2015 Metformin downregulated the I/R-induced expression of proinflammatory (TNF-alpha, TLR4, IL-1beta, Ccr2) and infiltrating monocyte (Ly6c) and macrophage (CD11b) markers. Metformin 0-9 interleukin 1 beta Rattus norvegicus 88-96 26379861-8 2015 There was no obvious effect on the cognitive function and neuroapoptosis after repeated use of propofol at a low dose for 5 days, whereas repeated use of propofol at a middle/high dose significantly increase the expression of apoptotic factors (caspase-3 and Bax), pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha), and impair the cognitive function. Propofol 154-162 interleukin 1 beta Rattus norvegicus 293-301 26133372-11 2015 An interleukin-1 receptor antagonist not only attenuated cell death but also abolished lipopolysaccharide-induced NR1 and serine racemase upregulation and increases in D-serine secretion, suggesting that interleukin-1beta-mediated NMDA receptor hyperfunction participates in lipopolysaccharide-induced tubular damage. D-serine 168-176 interleukin 1 beta Rattus norvegicus 204-221 25910811-9 2015 Furthermore, daily MAG-DHA treatment resulted in reduced proinflammatory marker levels such as CRP, IL-6, TNFalpha, and IL-1beta. docosahexaenoic acid monoacylglyceride 19-26 interleukin 1 beta Rattus norvegicus 120-128 26045616-10 2015 Metformin downregulated the I/R-induced expression of proinflammatory (TNF-alpha, TLR4, IL-1beta, Ccr2) and infiltrating monocyte (Ly6c) and macrophage (CD11b) markers. r 30-31 interleukin 1 beta Rattus norvegicus 88-96 26379924-6 2015 Compared with the neuropathic pain group, high doses of TAK-242 significantly inhibited the expression of p65, IL-1beta, and TNF-alpha; significantly increased the expression level of IkBalpha; and upregulated the heat pain and mechanic pain thresholds. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 56-63 interleukin 1 beta Rattus norvegicus 111-119 25964086-8 2015 Analysis of inflammatory cytokines declared that the inhibition of TNF-alpha, IL-1beta and IL-6 could be carried by juglone in response to high-fat diet rats. juglone 116-123 interleukin 1 beta Rattus norvegicus 78-86 26133170-0 2015 Increased CCL2, CCL3, CCL5, and IL-1beta cytokine concentration in piriform cortex, hippocampus, and neocortex after pilocarpine-induced seizures. Pilocarpine 117-128 interleukin 1 beta Rattus norvegicus 32-40 26351555-8 2015 Also IP and ICV administration of venlafaxine significantly decreased myeloperoxidase (MPO) activity and interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha production. Venlafaxine Hydrochloride 34-45 interleukin 1 beta Rattus norvegicus 105-127 26351555-12 2015 Also we have shown that anti-inflammatory effect of venlafaxine is mediated mostly through the inhibition of IL-1beta and TNF-alpha production and decreases MPO activity in the site of inflammation. Venlafaxine Hydrochloride 52-63 interleukin 1 beta Rattus norvegicus 109-117 26218952-18 2015 TNBS significantly increased the spinal expression of HMGB1 and proinflammatory cytokines IL-1beta, TNF-alpha, and IL-6. Trinitrobenzenesulfonic Acid 0-4 interleukin 1 beta Rattus norvegicus 90-98 26026045-6 2015 Both vessel denudation and cyclooxygenase blockade (by indomethacin), but not the nitric oxide (NO) antagonist L-NIO, inhibited the vasodilator effect of rIL-1beta. Indomethacin 55-67 interleukin 1 beta Rattus norvegicus 154-163 25783305-10 2015 Treatment with Dxp significantly reduced elevations in tissue homogenate levels of tumor necrosis factor-alpha and interleukin-1beta in the NEC+Dxp group (p=0.002 and p=0.01, respectively). dexpanthenol 15-18 interleukin 1 beta Rattus norvegicus 115-132 25783305-10 2015 Treatment with Dxp significantly reduced elevations in tissue homogenate levels of tumor necrosis factor-alpha and interleukin-1beta in the NEC+Dxp group (p=0.002 and p=0.01, respectively). dexpanthenol 144-147 interleukin 1 beta Rattus norvegicus 115-132 25645065-4 2015 KEY FINDINGS: Cyclopamine effectively attenuated inflammation and cartilage damage of AIA rats, as evidenced by reduced paw swelling, serum levels of tumor necrosis factors (TNF)-alpha, IL-1beta, IL-6 and histological scores of joint damage, increased proteoglycans expression and mRNA levels of COII and aggrecan in articular cartilage. cyclopamine 14-25 interleukin 1 beta Rattus norvegicus 186-194 25689466-7 2015 Survival rate, TNFalpha, and IL-1beta mRNA were improved in TNBS/Gln compared with TNBS/PBS (p < 0.05). Trinitrobenzenesulfonic Acid 60-64 interleukin 1 beta Rattus norvegicus 29-37 25689466-7 2015 Survival rate, TNFalpha, and IL-1beta mRNA were improved in TNBS/Gln compared with TNBS/PBS (p < 0.05). Glutamine 65-68 interleukin 1 beta Rattus norvegicus 29-37 25874913-8 2015 Atorvastatin attenuated CCI-induced inflammatory mediators (pAkt/Akt, COX-2, iNOS, EP1, and EP4) and reduced proinflammatory cytokines TNF-alpha and IL-1beta levels in DRG and spinal cord. CCI 24-27 interleukin 1 beta Rattus norvegicus 149-157 26055348-11 2015 Furthermore, resveratrol increased the expression of peroxisome proliferator-activated receptor delta, while decreasing the expression of ATP citrate lyase, suppressor of cytokine signaling-3, and interleukin-1beta. Resveratrol 13-24 interleukin 1 beta Rattus norvegicus 197-214 26020571-7 2015 The solutes normalized the rise in myeloperoxidase, TNFalpha, and IL-1beta induced by TNBS but did not affect levels of reduced glutathione or ICAM-1, while reducing the level of fecal calprotectin, an established marker for inflammatory bowel disease. Trinitrobenzenesulfonic Acid 86-90 interleukin 1 beta Rattus norvegicus 66-74 25874913-8 2015 Atorvastatin attenuated CCI-induced inflammatory mediators (pAkt/Akt, COX-2, iNOS, EP1, and EP4) and reduced proinflammatory cytokines TNF-alpha and IL-1beta levels in DRG and spinal cord. Atorvastatin 0-12 interleukin 1 beta Rattus norvegicus 149-157 26055348-12 2015 Our data suggest that resveratrol can prevent hepatic ER stress and regulate the expression of peroxisome proliferator-activated receptor delta, ATP citrate lyase, suppressor of cytokine signaling-3, tumor necrosis factor alpha, and interleukin-1beta in diet-induced obese rats, and these effects likely contribute to resveratrol"s protective function against excessive accumulation of fat in the liver. Resveratrol 22-33 interleukin 1 beta Rattus norvegicus 233-250 26399109-7 2015 RESULTS: Both the Toluidine blue and Safranine O staining were pale in the margin of femoral heads which were stimulated with IL-1beta for three days compared to that in control group. Tolonium Chloride 18-32 interleukin 1 beta Rattus norvegicus 126-134 26399109-7 2015 RESULTS: Both the Toluidine blue and Safranine O staining were pale in the margin of femoral heads which were stimulated with IL-1beta for three days compared to that in control group. safranine T 37-48 interleukin 1 beta Rattus norvegicus 126-134 26309556-6 2015 The expression levels of TNF-alpha IL-6 and IL-1beta were significantly upregulated after treatment with 6-OHDA. Oxidopamine 105-111 interleukin 1 beta Rattus norvegicus 44-52 26309556-7 2015 The 6-OHDA-stimulated mRNA and protein levels of TNF-alpha IL-6 and IL-1beta were reduced by lovastatin. Oxidopamine 4-10 interleukin 1 beta Rattus norvegicus 68-76 26309556-7 2015 The 6-OHDA-stimulated mRNA and protein levels of TNF-alpha IL-6 and IL-1beta were reduced by lovastatin. Lovastatin 93-103 interleukin 1 beta Rattus norvegicus 68-76 26309557-10 2015 Furthermore, DCA could markedly reduce the release of MMP-1, MMP-3 and IL-1beta in serum. Deoxycholic Acid 13-16 interleukin 1 beta Rattus norvegicus 71-79 26062761-13 2015 Administration of acetic acid resulted in increased levels of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, total nitrite/nitrate levels and nitric oxide synthase activity. Acetic Acid 18-29 interleukin 1 beta Rattus norvegicus 91-108 25891026-6 2015 In addition, rats with high-salt diet had higher levels of NOX-2, NOX-4 (subunits of NAD(P)H oxidase), angiotensin-converting enzyme (ACE), interleukin-1beta (IL-1beta), glutamate and NE, and lower levels of gamma-aminobutyric acid (GABA) and interleukin-10 (IL-10) in the PVN than normal diet rats. Salts 28-32 interleukin 1 beta Rattus norvegicus 140-157 25891026-6 2015 In addition, rats with high-salt diet had higher levels of NOX-2, NOX-4 (subunits of NAD(P)H oxidase), angiotensin-converting enzyme (ACE), interleukin-1beta (IL-1beta), glutamate and NE, and lower levels of gamma-aminobutyric acid (GABA) and interleukin-10 (IL-10) in the PVN than normal diet rats. Salts 28-32 interleukin 1 beta Rattus norvegicus 159-167 25981395-11 2015 SalB also exerted anti-inflammatory effects as indicated by the decreased TNF-alpha and IL-1beta levels in the brain tissue. salvianolic acid B 0-4 interleukin 1 beta Rattus norvegicus 88-96 25819555-9 2015 Together, the results here demonstrate that the febrile response in zymosan-induced arthritis in rats depends on the centrally acting pyrogenic cytokines TNF-alpha, IL-1beta, and IL-6, but does not depend on either CRF or ET-1. Zymosan 68-75 interleukin 1 beta Rattus norvegicus 165-173 26136944-10 2015 Inhalation of hydrogen gas at 2% concentration for 1 h significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, the expression of cytokines, including IL-6, TNF-alpha, early growth response protein 1 (Egr-1) and IL-1beta, and morphological damage. Hydrogen 14-22 interleukin 1 beta Rattus norvegicus 267-275 26937527-2 2015 Studies have shown that sleep deprivation increases interleukin 1 beta (IL-1beta), a pro-inflammatory cytokine and that increased IL-1beta levels cause reductions in Leydig cell production of testosterone. Testosterone 192-204 interleukin 1 beta Rattus norvegicus 130-138 26937527-3 2015 This study was therefore designed to determine the effects of methotrexate, an IL-1beta blocker on serum testosterone levels in sleep deprived male Wistar rats. Methotrexate 62-74 interleukin 1 beta Rattus norvegicus 79-87 26937527-3 2015 This study was therefore designed to determine the effects of methotrexate, an IL-1beta blocker on serum testosterone levels in sleep deprived male Wistar rats. Testosterone 105-117 interleukin 1 beta Rattus norvegicus 79-87 26937527-11 2015 RESULTS: Serum testosterone levels were significantly decreased while testicular IL-1beta was increased in SD and SD+Methotrexate compared with Control. sd+methotrexate 114-129 interleukin 1 beta Rattus norvegicus 81-89 25846801-10 2015 Various regimens of morphine reduced TWI, cortisol levels, Bax activity, caspase-3, caspase-9, TNF-alpha, and IL-1beta and lipid peroxidation. Morphine 20-28 interleukin 1 beta Rattus norvegicus 110-118 25746774-4 2015 This reactive oxygen species induction increased p38 MAPK phosphorylation and thioredoxin-interacting protein (TXNIP) expression and activated the NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome to produce interleukin-1beta in kidney glomeruli of fructose-fed rats. Fructose 264-272 interleukin 1 beta Rattus norvegicus 223-240 25746774-4 2015 This reactive oxygen species induction increased p38 MAPK phosphorylation and thioredoxin-interacting protein (TXNIP) expression and activated the NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome to produce interleukin-1beta in kidney glomeruli of fructose-fed rats. Reactive Oxygen Species 5-28 interleukin 1 beta Rattus norvegicus 223-240 26084225-15 2015 A parallel strong increase of plasma ACTH and corticosterone levels were significantly impaired by IL-1Ra suggesting a marked involvement of stress-induced stimulation of ACTH and corticosterone by IL-1beta in single restraint. Corticosterone 46-60 interleukin 1 beta Rattus norvegicus 198-206 25753843-7 2015 RESULTS: Our results showed that administration of CoQ10, amlodipine and their combination decreased colon tissue malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), prostaglandin E2 (PGE2), myeloperoxidase (MPO) and heat shock protein (HSP70) levels induced by intracolonic injection of acetic acid and restored many of the colon structure in histological examination. coenzyme Q10 51-56 interleukin 1 beta Rattus norvegicus 178-195 25753843-7 2015 RESULTS: Our results showed that administration of CoQ10, amlodipine and their combination decreased colon tissue malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), prostaglandin E2 (PGE2), myeloperoxidase (MPO) and heat shock protein (HSP70) levels induced by intracolonic injection of acetic acid and restored many of the colon structure in histological examination. coenzyme Q10 51-56 interleukin 1 beta Rattus norvegicus 197-205 25753843-7 2015 RESULTS: Our results showed that administration of CoQ10, amlodipine and their combination decreased colon tissue malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), prostaglandin E2 (PGE2), myeloperoxidase (MPO) and heat shock protein (HSP70) levels induced by intracolonic injection of acetic acid and restored many of the colon structure in histological examination. Amlodipine 58-68 interleukin 1 beta Rattus norvegicus 178-195 25753843-7 2015 RESULTS: Our results showed that administration of CoQ10, amlodipine and their combination decreased colon tissue malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), prostaglandin E2 (PGE2), myeloperoxidase (MPO) and heat shock protein (HSP70) levels induced by intracolonic injection of acetic acid and restored many of the colon structure in histological examination. Amlodipine 58-68 interleukin 1 beta Rattus norvegicus 197-205 25069044-10 2015 Telmisartan had a significant down-regulatory effect on IL-1beta expression. Telmisartan 0-11 interleukin 1 beta Rattus norvegicus 56-64 26084225-15 2015 A parallel strong increase of plasma ACTH and corticosterone levels were significantly impaired by IL-1Ra suggesting a marked involvement of stress-induced stimulation of ACTH and corticosterone by IL-1beta in single restraint. Corticosterone 180-194 interleukin 1 beta Rattus norvegicus 198-206 26084225-23 2015 Increased plasma IL-1beta level by a single restraint stress is significantly involved in ACTH and corticosterone secretion. Corticosterone 99-113 interleukin 1 beta Rattus norvegicus 17-25 25672255-7 2015 In addition, BLM-induced increased expression of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, cyclooxygenase-2, prostaglandin E2, malondialdehyde, inducible nitric oxide synthase and nitric oxide in rats, which was also suppressed by Tan IIA injection. Bleomycin 13-16 interleukin 1 beta Rattus norvegicus 78-100 25818190-8 2015 KEY FINDINGS: MDA, NO and 8-OH/Gua levels and IL-1beta and TNF-alpha gene expression were significantly lower in the GCMHB-500 group compared to the FCG group, whereas tGSH was significantly higher in the GCMHB-500 group than in the FCG group. gcmhb 117-122 interleukin 1 beta Rattus norvegicus 46-54 26502574-0 2015 The Inhibitory Effect of Ethanol on Interleukin-1 beta-Induced Suppression of Contractile Response in the Rat Superior Mesenteric Artery. Ethanol 25-32 interleukin 1 beta Rattus norvegicus 36-54 25647547-5 2015 The results showed that icariin significantly reduced the increase in the mRNA expression of tumor necrosis factor alpha, interleukin (IL)-1beta and IL-6 that occurred in response to LPS. icariin 24-31 interleukin 1 beta Rattus norvegicus 122-144 25846008-5 2015 CHPG or VU0360172 administration significantly reduces the numbers of activated microglia and the protein and mRNA levels of pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha at 24 h after SAH. N-cyclobutyl-6-((3-fluorophenyl)ethynyl)nicotinamide 8-17 interleukin 1 beta Rattus norvegicus 152-160 25735949-3 2015 Oral administration of RA (100 mg/kg b.w) significantly (p < 0.05) increased the insulin sensitivity index (ISI0,120), while the levels of blood glucose, HbA1c, advanced glycation end products (AGE), TNF-alpha, IL-1beta, IL 6, NO, p-JNK, P38 MAPK and NF-kappaB were significantly reduced, with a concomitant elevation in the plasma insulin levels in diabetic rats. rosmarinic acid 23-25 interleukin 1 beta Rattus norvegicus 214-222 26502574-2 2015 This study examined the effect of ethanol on IL-1 beta-mediated suppression of phenylephrine-induced contractility and inducible nitric oxide synthase (iNOS) expression in the rat superior mesenteric artery (SMA). Ethanol 34-41 interleukin 1 beta Rattus norvegicus 45-54 26502574-2 2015 This study examined the effect of ethanol on IL-1 beta-mediated suppression of phenylephrine-induced contractility and inducible nitric oxide synthase (iNOS) expression in the rat superior mesenteric artery (SMA). Phenylephrine 79-92 interleukin 1 beta Rattus norvegicus 45-54 26502574-3 2015 IL-1 beta suppressed the phenylephrine-induced contractile response, and this effect was inhibited by ethanol. Phenylephrine 25-38 interleukin 1 beta Rattus norvegicus 0-9 26242125-14 2015 GMT protected neurons by down-regulating protein expressions of TLR2, ERK, p-ERK, p38, p-p38 and contents of IL-1beta and IL-6. GlcNAc-Mal 0-3 interleukin 1 beta Rattus norvegicus 109-117 26502574-3 2015 IL-1 beta suppressed the phenylephrine-induced contractile response, and this effect was inhibited by ethanol. Ethanol 102-109 interleukin 1 beta Rattus norvegicus 0-9 26502574-4 2015 The IL-1 beta-mediated effects were also blocked by cycloheximide, an inhibitor of protein synthesis, as well as AMT and 1400W, which are iNOS inhibitors, and PTIO, an NO scavenger. Cycloheximide 52-65 interleukin 1 beta Rattus norvegicus 4-13 26502574-4 2015 The IL-1 beta-mediated effects were also blocked by cycloheximide, an inhibitor of protein synthesis, as well as AMT and 1400W, which are iNOS inhibitors, and PTIO, an NO scavenger. indopan 113-116 interleukin 1 beta Rattus norvegicus 4-13 26502574-4 2015 The IL-1 beta-mediated effects were also blocked by cycloheximide, an inhibitor of protein synthesis, as well as AMT and 1400W, which are iNOS inhibitors, and PTIO, an NO scavenger. N-((3-(aminomethyl)phenyl)methyl)ethanimidamide 121-126 interleukin 1 beta Rattus norvegicus 4-13 26502574-4 2015 The IL-1 beta-mediated effects were also blocked by cycloheximide, an inhibitor of protein synthesis, as well as AMT and 1400W, which are iNOS inhibitors, and PTIO, an NO scavenger. 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide 159-163 interleukin 1 beta Rattus norvegicus 4-13 26502574-8 2015 Furthermore, these data suggest that ethanol inhibits the effects of IL-1 beta on the contractile response via inhibition of iNOS, rather than COX-2. Ethanol 37-44 interleukin 1 beta Rattus norvegicus 69-78 25847619-9 2015 The influence on the level of cAMP in inflammatory cells (shown in RAW 264.7 macrophages) and subsequent inhibition of cytokine (TNFalpha, IL-1beta) release can also be one of the important mechanisms of their action. Cyclic AMP 30-34 interleukin 1 beta Rattus norvegicus 139-147 25891268-9 2015 Safranal treatment suppressed immunoreactivity and expression of the inflammatory cytokines IL-1beta, TNF-alpha, and p38 MAPK, and increased expression of IL-10 after SCI, suggesting an anti-inflammatory effect. safranal 0-8 interleukin 1 beta Rattus norvegicus 92-100 25747863-13 2015 Besides, nanocurcumin decreased CSF levels of TNF-alpha and IL-1beta, which may contribute to the extrinsic antiapoptotic effect. nanocurcumin 9-21 interleukin 1 beta Rattus norvegicus 60-68 25749305-9 2015 We further showed that IL-1beta was localized to microglia and that minocycline inhibited the carrageenan-induced increases in spinal Iba-1 and IL-1beta expression. Minocycline 68-79 interleukin 1 beta Rattus norvegicus 144-152 25749305-9 2015 We further showed that IL-1beta was localized to microglia and that minocycline inhibited the carrageenan-induced increases in spinal Iba-1 and IL-1beta expression. Carrageenan 94-105 interleukin 1 beta Rattus norvegicus 23-31 25749305-9 2015 We further showed that IL-1beta was localized to microglia and that minocycline inhibited the carrageenan-induced increases in spinal Iba-1 and IL-1beta expression. Carrageenan 94-105 interleukin 1 beta Rattus norvegicus 144-152 25605261-6 2015 Both in vivo and in vitro studies showed that CTS suppressed the production of proinflammatory cytokines including interleukin 1beta, tumor necrosis factor alpha, and interleukin 17alpha production and downregulated the production and activity of matrix metalloproteinase 9. cryptotanshinone 46-49 interleukin 1 beta Rattus norvegicus 115-161 26762065-8 2015 RESULTS: Total saponins of Panacis Majoris Rhizoma might significantly decrease the levels of serum TNF-alpha, IL-1beta, IL-6 and IL-8; decrease myocardial hypertrophy indexes, myocardial infarct size, degree of ventricular dilatation and myocardial interstitial collagen volume fraction; improve heart tissue morphology and cardiac function; downregulate protein expression of pIkappaB-alpha and NF-kappaBp65; and upregulate protein expression of SIRT1. Saponins 15-23 interleukin 1 beta Rattus norvegicus 111-119 26025257-2 2015 Within term-equivalent rat brains exposed to systemic lipopolysaccharide (LPS) plus HI, it was previously showed that neurons produce IL-1beta earlier than do glial cells, and that blocking IL-1 was neuroprotective. hi 84-86 interleukin 1 beta Rattus norvegicus 134-142 25747863-8 2015 The levels of IL-1beta and IL-6 were increased in animals subjected to SAH, compared with the healthy controls, but absent in the high dose nanocurcumin+SAH group. nanocurcumin 140-152 interleukin 1 beta Rattus norvegicus 14-22 26242127-23 2015 Contents of FIB, serum levels of IL-1beta and IL-6 decreased significantly in the MTX group (P < 0.05). Methotrexate 82-85 interleukin 1 beta Rattus norvegicus 33-41 26242127-24 2015 Contents of FIB, serum levels of IL-1beta and IL-6 decreased significantly in the TMP group and the MTX plus TMP group (P < 0.05). tetramethylpyrazine 82-85 interleukin 1 beta Rattus norvegicus 33-41 26242127-24 2015 Contents of FIB, serum levels of IL-1beta and IL-6 decreased significantly in the TMP group and the MTX plus TMP group (P < 0.05). Methotrexate 100-103 interleukin 1 beta Rattus norvegicus 33-41 25791226-6 2015 Interestingly, icariin negatively regulated the activation of the nod-like receptor protein 3 (NLRP3) inflammasome/caspase-1/IL-1beta axis in the hippocampus of CMS rats. icariin 15-22 interleukin 1 beta Rattus norvegicus 125-133 25791226-7 2015 These results confirm that icariin exerts antidepressant-like effects, which may be mediated, at least in part, by enhanced antioxidant status and anti-inflammatory effects on the brain tissue via the inhibition of NF-kappaB signaling activation and the NLRP3-inflammasome/caspase-1/IL-1beta axis. icariin 27-34 interleukin 1 beta Rattus norvegicus 283-291 25988362-6 2015 Furthermore, such a curcumin treatment reduced CFA-induced activation of glial cells and production of inflammatory mediators [interleukin-1beta (IL-1beta), monocyte chemoattractant protein-1 (MCP-1), and monocyte inflammatory protein-1 (MIP-1alpha)] in the spinal cord. Curcumin 20-28 interleukin 1 beta Rattus norvegicus 127-144 25988362-7 2015 Curcumin also decreased lipopolysaccharide-induced production of IL-1beta, tumor necrosis factor-alpha, MCP-1, and MIP-1alpha in cultured astrocytes and microglia. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 65-73 25988362-6 2015 Furthermore, such a curcumin treatment reduced CFA-induced activation of glial cells and production of inflammatory mediators [interleukin-1beta (IL-1beta), monocyte chemoattractant protein-1 (MCP-1), and monocyte inflammatory protein-1 (MIP-1alpha)] in the spinal cord. Curcumin 20-28 interleukin 1 beta Rattus norvegicus 146-154 25839444-10 2015 Then, we firstly demonstrated that prophylactic 2mM/kg of lithium alleviated splenectomy-induced cognitive impairments, decreased splenectomy-associated systemic, central, and hippocampal TNF-alpha and interleukin (IL)-1beta expression and reduced the increase of CD11b(+) area in hippocampal CA1 region caused by the surgery. Lithium 58-65 interleukin 1 beta Rattus norvegicus 202-224 25651569-8 2015 In vivo, intrarenal IL-1beta expression and macrophage infiltration increased in HFD-fed OLETF rats. oletf 89-94 interleukin 1 beta Rattus norvegicus 20-28 26044239-7 2015 RESULTS: In CAPE treated group, decreased serum levels of proinflammatory cytokines (TNF-alpha, IL-6, IL-1beta) and CRP (p < 0.05), additionally increased serum levels of antioxidant parameters (PONS, TAS) (p < 0.05), were observed after IO. caffeic acid phenethyl ester 12-16 interleukin 1 beta Rattus norvegicus 102-110 25611692-12 2015 Pioglitazone decreased the proliferation of microglia and astrocyte and lowered the expression of proinflammatory cytokines IL-1beta and TNF-alpha in the white matter. Pioglitazone 0-12 interleukin 1 beta Rattus norvegicus 124-132 25488902-1 2015 Interleukin (IL)-1beta, the sole proinflammatory cytokine released from pancreas-infiltrating macrophages, inhibits glucose-stimulated insulin secretion (GSIS), causing hyperglycemia in Cohen diabetes-sensitive (CDs) rats fed a diabetogenic-diet (CDs-HSD). Glucose 116-123 interleukin 1 beta Rattus norvegicus 0-22 25488902-1 2015 Interleukin (IL)-1beta, the sole proinflammatory cytokine released from pancreas-infiltrating macrophages, inhibits glucose-stimulated insulin secretion (GSIS), causing hyperglycemia in Cohen diabetes-sensitive (CDs) rats fed a diabetogenic-diet (CDs-HSD). cds 212-215 interleukin 1 beta Rattus norvegicus 0-22 25488902-1 2015 Interleukin (IL)-1beta, the sole proinflammatory cytokine released from pancreas-infiltrating macrophages, inhibits glucose-stimulated insulin secretion (GSIS), causing hyperglycemia in Cohen diabetes-sensitive (CDs) rats fed a diabetogenic-diet (CDs-HSD). cds 247-250 interleukin 1 beta Rattus norvegicus 0-22 25488902-7 2015 Altogether, these data demonstrate that blocking IL-1beta action by IL-1betaAb counteracted beta-cell dysfunction and glucose intolerance, supporting the notion that prevention of pancreas infiltration by macrophages producing IL-1beta is of crucial importance for the preservation of beta-cell function and prevention of diabetes. Glucose 118-125 interleukin 1 beta Rattus norvegicus 49-57 25488902-7 2015 Altogether, these data demonstrate that blocking IL-1beta action by IL-1betaAb counteracted beta-cell dysfunction and glucose intolerance, supporting the notion that prevention of pancreas infiltration by macrophages producing IL-1beta is of crucial importance for the preservation of beta-cell function and prevention of diabetes. Glucose 118-125 interleukin 1 beta Rattus norvegicus 68-76 26069367-5 2015 RESULTS: The results showed that intraplantar injection of carrageenan led to time-dependent development of peripheral inflammation, which resulted in a significant increase in the levels of tumor necrosis factor alpha (TNF-alpha) and interleukin 1 (IL-1) beta, nitric oxide (NO) and prostaglandin E2 (PGE2) and also iNOS and COX-2 protein expression in inflamed paw. Carrageenan 59-70 interleukin 1 beta Rattus norvegicus 250-260 25776070-4 2015 In urethane-anesthetized Sprague-Dawley rats, direct microinjection of tumor necrosis factor (TNF)-alpha (25 ng) or interleukin (IL)-1beta (25 ng) into SFO increased mean blood pressure, heart rate, and renal sympathetic nerve activity within 15 to 20 minutes, mimicking the response to systemically administered proinflammatory cytokines. Urethane 3-11 interleukin 1 beta Rattus norvegicus 116-138 26069367-11 2015 CONCLUSIONS: Collectively, the anti-inflammatory mechanisms of EA might be related to the decrease in the level of MDA, iNOS, and COX-2 in the edema paw via the suppression of pro-inflammatory cytokines (TNFalpha, IL1 beta), NO and PGE2 overproduction. Ellagic Acid 63-65 interleukin 1 beta Rattus norvegicus 214-222 25957427-9 2015 RESULTS: The methotrexate group had significantly higher tissue levels of tumor necrosis factor-alpha (P = .008), interleukin-1beta (P = .04), nitric oxide (P < .001), and adenosine deaminase (P < .001) than the methotrexate and infliximab group after the 5-day study. Methotrexate 13-25 interleukin 1 beta Rattus norvegicus 114-131 25437532-11 2015 Genes encoding for PYCARD (ASC), TXNIP, NLRP3, caspase-1, and IL-1beta and 18 were significantly up-regulated in hydroxy-L-proline fed rats but in the group that received apocynin these genes were down-regulated in the cortex and medulla. Hydroxyproline 113-130 interleukin 1 beta Rattus norvegicus 62-70 25910227-4 2015 Results revealed that the ethanol-fed group showed increases in plasma AST and ALT activities, the endotoxin level, the hepatic triglyceride (TG) level, and hepatic tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 levels, and a decrease in the hepatic IL-10 level. Ethanol 26-33 interleukin 1 beta Rattus norvegicus 200-222 25439190-7 2015 RESULTS: We established that PAR, as a prototype compound, suppressed lipopolysaccharide (LPS)- and tumour necrosis factor (TNF)-alpha-induced increases in matrix metalloproteinase (MMP)-1, MMP-3, inducible nitric oxide synthase (iNOS), and interleukin (IL)-1beta mRNA in chondrocytes. parthenolide 29-32 interleukin 1 beta Rattus norvegicus 241-263 25835215-4 2015 Using a global PA rat model, we report here evidence that hypoxia increases PARP-1 activity, triggering a signalling cascade leading to nuclear translocation of the NF-kappaB subunit p65, modulating the expression of IL-1beta and TNF-alpha, pro-inflammatory molecules, increasing apoptotic-like cell death in mesencephalon of neonate rats, monitored with Western blots, qPCR, TUNEL and ELISA. Protactinium 15-17 interleukin 1 beta Rattus norvegicus 217-225 25933224-6 2015 BBG also ameliorated liver fibrosis and down-regulated hepatic interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), PDGF, IL-1beta, transforming growth factor-beta (TGF-beta), p-extracellular-signal-regulated kinases (ERK), and alpha-smooth muscle actin (alpha-SMA) expressions in CBDL rats. coomassie Brilliant Blue 0-3 interleukin 1 beta Rattus norvegicus 132-140 25697231-10 2015 Compared to the IR group, rats receiving PAG or HA showed significantly higher levels of TLR-2, TLR-4, nuclear NF-kappaB p65, phosphorylated ASK1, phosphorylated TRAF2, IL-1beta, IL-6, IL-18 and TNF-alpha (p < 0.01), more severe acute kidney injury (p < 0.05) and increased apoptosis (p < 0.01). propargylglycine 41-44 interleukin 1 beta Rattus norvegicus 169-177 25681271-9 2015 Also, HAMI 3379 inhibited release of the cytokines IL-1beta, interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) into the serum and cerebrospinal fluid 24h after MCAO. 3-(((3-carboxycyclohexyl)amino)carbonyl)-4-(3-(4-(4-(cyclohexyloxy)butoxy)phenyl)propoxy)benzoic acid 6-15 interleukin 1 beta Rattus norvegicus 51-59 25931810-8 2015 Furthermore, paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin, alpha-SMA, and collagen I, and suppressed the infiltration of macrophages and production of TNF-alpha, IL-1beta, TGF-beta, and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. Paclitaxel 13-23 interleukin 1 beta Rattus norvegicus 209-217 26535039-9 2015 Furthermore, LCD at a dose of 50, 100 and 400 mg/Kg was found to reduce significantly LPS induced tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta production in female Sprague Dawley (SD) rats. lps 86-89 interleukin 1 beta Rattus norvegicus 136-158 25748315-6 2015 Moreover, the over-expression in IL-1beta and TNF-alpha as well as the extensive astrogliosis and microgliosis in hippocampus induced by Abeta1-42 were significantly reduced following administration of pratensein. 4'-methoxy-3',5,7-trihydroxyisoflavone 202-212 interleukin 1 beta Rattus norvegicus 33-41 25686667-10 2015 RESULTS: Depletion of IL-1beta or TNF-alpha effectively eliminated the ability of AM media to enhance the response of endothelial and epithelial cells to oxidative stress. am media 82-90 interleukin 1 beta Rattus norvegicus 22-30 25888837-6 2015 Lycopene also modified the levels of immunoregulatory cytokines (IL- 1beta and IL-6) favourably. Lycopene 0-8 interleukin 1 beta Rattus norvegicus 65-74 25848767-14 2015 Protective effects of baclofen treatment on ALI were possibly mediated by inhibition of TNF-alpha- and IL-1beta-mediated inflammatory signaling. Baclofen 22-30 interleukin 1 beta Rattus norvegicus 103-111 25832428-7 2015 RESULTS: In BDL rats, EGCG treatment significantly ameliorates liver necrosis, inflammation and fibrosis, and suppressed expression of the genes associated with liver inflammation and fibrogenesis, including TNF-alpha, IL-1beta, TGF-beta1, MMP-9, alpha-SMA, and COL1A1. epigallocatechin gallate 22-26 interleukin 1 beta Rattus norvegicus 219-227 27307952-12 2015 Use of 6-OHDA to induce the PD significantly increased the levels of TNF-alpha (P<0.001) and IL-1beta (P<0.001) in MFB-lesioned rats. Oxidopamine 7-13 interleukin 1 beta Rattus norvegicus 96-104 25780418-10 2015 Reverse transcription-quantitative polymerase chain reaction demonstrated that picroside II inhibited the increase of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and intercellular adhesion molecule (ICAM)-1 expression induced by I/R injury. picroside II 79-91 interleukin 1 beta Rattus norvegicus 153-175 25975502-5 2015 RESULTS: FA-Pr-Al in combination reduced neurological deficits, decreased infarct volume and inhibited the expression levels of IL-1beta and NPY (all P<0.05) compared with the model group. fa-pr-al 9-17 interleukin 1 beta Rattus norvegicus 128-136 24962643-5 2015 Our data indicated that ALA pretreatment reduced LPS-stimulated release of inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1 beta (IL-1beta), as well as IL-6, in HBZY-1 cell supernatant. Thioctic Acid 24-27 interleukin 1 beta Rattus norvegicus 148-171 25759121-3 2015 Gentiopicroside was given orally and it markedly reduced the pancreatitis-evoked increase of serum amylase and lipase activity, decreased the pancreas mass/body mass index, tissue water content, TNF-alpha and IL-1beta concentrations, and attenuated the histopathological changes and NF-kappaB p65 protein expression in pancreatic tissue. gentiopicroside 0-15 interleukin 1 beta Rattus norvegicus 209-217 24962643-5 2015 Our data indicated that ALA pretreatment reduced LPS-stimulated release of inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1 beta (IL-1beta), as well as IL-6, in HBZY-1 cell supernatant. Thioctic Acid 24-27 interleukin 1 beta Rattus norvegicus 173-181 25975052-8 2015 Levels of IL-1beta in joint fluid and MMP-1 in sera from the BHF- and GS-treated groups were significantly reduced. alpha-naphthoflavone 61-64 interleukin 1 beta Rattus norvegicus 10-18 25596949-1 2015 OBJECTIVE: This study aimed to assess the chondroprotective potential of atorvastatin in rat"s cartilage explant culture model of osteoarthritis, stimulated by interleukin-1beta (IL-1beta). Atorvastatin 73-85 interleukin 1 beta Rattus norvegicus 160-177 25596949-1 2015 OBJECTIVE: This study aimed to assess the chondroprotective potential of atorvastatin in rat"s cartilage explant culture model of osteoarthritis, stimulated by interleukin-1beta (IL-1beta). Atorvastatin 73-85 interleukin 1 beta Rattus norvegicus 179-187 25596949-4 2015 RESULTS: Atorvastatin inhibited IL-1beta-induced GAGs release, TNF-alpha, MMP-13, and O2(-) with no effect on TIMP-1 and NO. Atorvastatin 9-21 interleukin 1 beta Rattus norvegicus 32-40 25596949-4 2015 RESULTS: Atorvastatin inhibited IL-1beta-induced GAGs release, TNF-alpha, MMP-13, and O2(-) with no effect on TIMP-1 and NO. Superoxides 86-88 interleukin 1 beta Rattus norvegicus 32-40 25596949-7 2015 CONCLUSION: The present study suggests that atorvastatin has the ability to protect cartilage degradation following IL-1beta-stimulated cartilage in in vitro OA model and supports additional therapeutic application of atorvastatin in OA. Atorvastatin 44-56 interleukin 1 beta Rattus norvegicus 116-124 25596949-7 2015 CONCLUSION: The present study suggests that atorvastatin has the ability to protect cartilage degradation following IL-1beta-stimulated cartilage in in vitro OA model and supports additional therapeutic application of atorvastatin in OA. Atorvastatin 218-230 interleukin 1 beta Rattus norvegicus 116-124 25847612-4 2015 In addition, TMP significantly protected the liver from CCl4-caused injury and fibrogenesis by suppressing inflammation with reducing levels of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), NLRP3, nuclear factor-kappa B (NF-kappaB) and interleukin-1beta (IL-1beta). tetramethylpyrazine 13-16 interleukin 1 beta Rattus norvegicus 265-282 25847612-4 2015 In addition, TMP significantly protected the liver from CCl4-caused injury and fibrogenesis by suppressing inflammation with reducing levels of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), NLRP3, nuclear factor-kappa B (NF-kappaB) and interleukin-1beta (IL-1beta). tetramethylpyrazine 13-16 interleukin 1 beta Rattus norvegicus 284-292 25908625-0 2015 Ginsenoside Ro suppresses interleukin-1beta-induced apoptosis and inflammation in rat chondrocytes by inhibiting NF-kappaB. Ginsenosides 0-11 interleukin 1 beta Rattus norvegicus 26-43 25908625-1 2015 This study investigated effects of Ginsenoside Ro (Ro) on interleukin-1beta (IL-1beta)-induced apoptosis and inflammation in rat chondrocytes. ginsenoside Ro 35-49 interleukin 1 beta Rattus norvegicus 58-75 25908625-1 2015 This study investigated effects of Ginsenoside Ro (Ro) on interleukin-1beta (IL-1beta)-induced apoptosis and inflammation in rat chondrocytes. ginsenoside Ro 35-49 interleukin 1 beta Rattus norvegicus 77-85 25626516-4 2015 Protective B-CA effects correlated with decreased inflammatory responses as indicated by inhibition of microglia and astrocyte activation [stained with ionized calcium-binding adapter molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP) antibody, respectively], as well as suppression of tumor necrosis factor-alpha, interleukin-1beta, and cyclooxygenase-2 overproduction in the ipsilateral cortex of ischemic rat. bromochloroacetic acid 11-15 interleukin 1 beta Rattus norvegicus 326-343 25975052-8 2015 Levels of IL-1beta in joint fluid and MMP-1 in sera from the BHF- and GS-treated groups were significantly reduced. Glucosamine 70-72 interleukin 1 beta Rattus norvegicus 10-18 24965599-10 2015 IL-1beta knockdown by siRNA in vitro or by lentivirus in vivo can reverse cell swelling, brain edema and neurologic function deficiencies induced by HI. hi 149-151 interleukin 1 beta Rattus norvegicus 0-8 25888442-0 2015 Inhibition of interleukin-1beta-stimulated dedifferentiation of chondrocytes via controlled release of CrmA from hyaluronic acid-chitosan microspheres. crma 103-107 interleukin 1 beta Rattus norvegicus 14-31 25815839-9 2015 The consequence of VILI by H&E stain showed inducing lung congestion and increasing the expression of pro-inflammatory cytokines such as TNF-alpha and IL-1beta in the lung tissue homogenization, serum, and BALF, respectively. Adenosine Monophosphate 29-32 interleukin 1 beta Rattus norvegicus 155-163 25788673-4 2015 Specifically, the activation of the CX3CR1 receptor by fractalkine induces the release of interleukin-1beta from microglia, which modulates NMDA signaling in postsynaptic neurons, leading to the release of an eicosanoid messenger, which ultimately enhances presynaptic neurotransmitter release. N-Methylaspartate 140-144 interleukin 1 beta Rattus norvegicus 90-107 25788673-4 2015 Specifically, the activation of the CX3CR1 receptor by fractalkine induces the release of interleukin-1beta from microglia, which modulates NMDA signaling in postsynaptic neurons, leading to the release of an eicosanoid messenger, which ultimately enhances presynaptic neurotransmitter release. Eicosanoids 209-219 interleukin 1 beta Rattus norvegicus 90-107 24828341-10 2015 A preliminary study with a lower Cd dose (0.5 mg/kg) revealed some of the same outcomes noted here (mononuclear cell infiltration into lungs, increases in PBMC IL-1beta mRNA levels), but differential (increased IL-17 mRNA levels) or newly detected outcomes (increased levels of IL-1alpha mRNA) as well. Cadmium 33-35 interleukin 1 beta Rattus norvegicus 160-168 25511383-4 2015 Using the method of rebreathing with hyperoxic gas mixture we demonstrate that the slope of the ventilatory response to carbon dioxide decreased almost twofold from 5.6+-0.52 to 2.5+-0.28 ml min(-1)mmHg(-1) (p<0.01) 40 min after cerebroventricular administration of IL-1beta. Carbon Dioxide 120-134 interleukin 1 beta Rattus norvegicus 269-277 25511383-6 2015 Diclofenac pretreatment eliminated these respiratory effects of IL-1beta. Diclofenac 0-10 interleukin 1 beta Rattus norvegicus 64-72 25888442-0 2015 Inhibition of interleukin-1beta-stimulated dedifferentiation of chondrocytes via controlled release of CrmA from hyaluronic acid-chitosan microspheres. hyaluronic acid-chitosan 113-137 interleukin 1 beta Rattus norvegicus 14-31 25888442-2 2015 In this study, we investigated the controlled-released cytokine response modifier A (CrmA) from hyaluronic acid (HA)-chitosan (CS) microspheres to improve interleukin-1beta (IL-1beta)-stimulated dedifferentiation of chondrocytes. Hyaluronic Acid 96-111 interleukin 1 beta Rattus norvegicus 155-172 25888442-2 2015 In this study, we investigated the controlled-released cytokine response modifier A (CrmA) from hyaluronic acid (HA)-chitosan (CS) microspheres to improve interleukin-1beta (IL-1beta)-stimulated dedifferentiation of chondrocytes. Hyaluronic Acid 96-111 interleukin 1 beta Rattus norvegicus 174-182 25888442-2 2015 In this study, we investigated the controlled-released cytokine response modifier A (CrmA) from hyaluronic acid (HA)-chitosan (CS) microspheres to improve interleukin-1beta (IL-1beta)-stimulated dedifferentiation of chondrocytes. Hyaluronic Acid 113-115 interleukin 1 beta Rattus norvegicus 155-172 25888442-2 2015 In this study, we investigated the controlled-released cytokine response modifier A (CrmA) from hyaluronic acid (HA)-chitosan (CS) microspheres to improve interleukin-1beta (IL-1beta)-stimulated dedifferentiation of chondrocytes. Hyaluronic Acid 113-115 interleukin 1 beta Rattus norvegicus 174-182 25888442-2 2015 In this study, we investigated the controlled-released cytokine response modifier A (CrmA) from hyaluronic acid (HA)-chitosan (CS) microspheres to improve interleukin-1beta (IL-1beta)-stimulated dedifferentiation of chondrocytes. Chitosan 117-125 interleukin 1 beta Rattus norvegicus 155-172 25888442-2 2015 In this study, we investigated the controlled-released cytokine response modifier A (CrmA) from hyaluronic acid (HA)-chitosan (CS) microspheres to improve interleukin-1beta (IL-1beta)-stimulated dedifferentiation of chondrocytes. Chitosan 117-125 interleukin 1 beta Rattus norvegicus 174-182 25888442-2 2015 In this study, we investigated the controlled-released cytokine response modifier A (CrmA) from hyaluronic acid (HA)-chitosan (CS) microspheres to improve interleukin-1beta (IL-1beta)-stimulated dedifferentiation of chondrocytes. Chitosan 127-129 interleukin 1 beta Rattus norvegicus 155-172 25888442-2 2015 In this study, we investigated the controlled-released cytokine response modifier A (CrmA) from hyaluronic acid (HA)-chitosan (CS) microspheres to improve interleukin-1beta (IL-1beta)-stimulated dedifferentiation of chondrocytes. Chitosan 127-129 interleukin 1 beta Rattus norvegicus 174-182 25888442-4 2015 HA-CS-CrmA microspheres were added to the medium after IL-1beta was co-cultured with freshly isolated rat chondrocytes for 48 hours. ha-cs 0-5 interleukin 1 beta Rattus norvegicus 55-63 25782157-10 2015 In vitro, PACAP prevented IL-1beta-induced chondrocyte apoptosis, as determined by MTT assay; Hoechst staining and western blots of apoptotic-related proteins. monooxyethylene trimethylolpropane tristearate 83-86 interleukin 1 beta Rattus norvegicus 26-34 25573175-8 2015 In addition, L-NAME induced a shift toward proinflammatory M1 macrophage polarity, as indicated by elevated hepatic CD11c (P < 0.05) and IL-1beta (P = 0.07) mRNA in OLETF rats and reduced expression of the anti-inflammatory M2 markers CD163 and CD206 (P < 0.05) in LETO rats. NG-Nitroarginine Methyl Ester 13-19 interleukin 1 beta Rattus norvegicus 140-148 25782157-10 2015 In vitro, PACAP prevented IL-1beta-induced chondrocyte apoptosis, as determined by MTT assay; Hoechst staining and western blots of apoptotic-related proteins. hoechst 94-101 interleukin 1 beta Rattus norvegicus 26-34 25885968-11 2015 Real-time PCR and Western blot analysis of the female brain revealed that DOCA/salt treatment enhanced the mRNA and protein expression for both antihypertensive components including AT2-R, angiotensin-converting enzyme (ACE)-2, and interleukin (IL)-10 and hypertensive components including angiotensin receptor type 1 (AT1-R), ACE-1, tumor necrosis factor (TNF)-alpha, and IL-1beta, but decreased mRNA expression of renin in the PVN. Desoxycorticosterone Acetate 74-78 interleukin 1 beta Rattus norvegicus 373-381 25885968-11 2015 Real-time PCR and Western blot analysis of the female brain revealed that DOCA/salt treatment enhanced the mRNA and protein expression for both antihypertensive components including AT2-R, angiotensin-converting enzyme (ACE)-2, and interleukin (IL)-10 and hypertensive components including angiotensin receptor type 1 (AT1-R), ACE-1, tumor necrosis factor (TNF)-alpha, and IL-1beta, but decreased mRNA expression of renin in the PVN. Salts 79-83 interleukin 1 beta Rattus norvegicus 373-381 25586177-6 2015 Similar differential effects of IL-1beta depending on concentration were observed after 15 min of KCl stimulation but were prevented by diazoxide. Potassium Chloride 98-101 interleukin 1 beta Rattus norvegicus 32-40 25732721-7 2015 Together, our findings suggest that pre-activation of MSCs with TNF-alpha, IL-1beta and nitric oxide enhances its paracine effects on RIII via a heme oxygenase-1 dependent mechanism, which may help us to maximize the paracrine potential of MSCs. paracine 114-122 interleukin 1 beta Rattus norvegicus 75-83 25586177-6 2015 Similar differential effects of IL-1beta depending on concentration were observed after 15 min of KCl stimulation but were prevented by diazoxide. Diazoxide 136-145 interleukin 1 beta Rattus norvegicus 32-40 25586177-10 2015 These results indicate that 2 h of exposure of beta cells to a low but not a high concentration of IL-1beta enhances glucose-stimulated insulin secretion through focal adhesion and actin remodeling, as well as modulation of gene expression. Glucose 117-124 interleukin 1 beta Rattus norvegicus 99-107 25440843-11 2015 Intraperitoneal administration of Gly (60mg/kg) significantly reduced the levels of serum TNF-alpha and IL-1beta (P<0.01). Glycyrrhizic Acid 34-37 interleukin 1 beta Rattus norvegicus 104-112 25445477-3 2015 Intracisternal administration of high dose TBOA (10 mug) produced thermal hyperalgesia in naive rats but significantly attenuated the thermal hyperalgesia in rats that had been pretreated with interleukin (IL)-1beta or Complete Freund"s Adjuvant (CFA). benzyloxyaspartate 43-47 interleukin 1 beta Rattus norvegicus 193-215 25445477-7 2015 In contrast, intracisternal administration of TBOA significantly decreased the up-regulation of c-Fos immunoreactivity in the medullary dorsal horn of IL-1beta- and CFA-treated rats. benzyloxyaspartate 46-50 interleukin 1 beta Rattus norvegicus 151-159 25576195-0 2015 17beta-estradiol protects against apoptosis induced by interleukin-1beta in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13. Estradiol 0-16 interleukin 1 beta Rattus norvegicus 55-72 25445065-7 2015 Protein analysis using multiplex assays and ELISA showed that polyI:C significantly increased maternal serum concentrations of interleukin-1beta, tumor necrosis factor, and CXCL1 3h after administration. Poly I-C 62-69 interleukin 1 beta Rattus norvegicus 127-144 25576195-1 2015 In our previous study, 17beta-estradiol was proved to protect rat annulus fibrosus cells against apoptosis induced by interleukin-1beta (IL-1beta). Estradiol 23-39 interleukin 1 beta Rattus norvegicus 118-135 25576195-1 2015 In our previous study, 17beta-estradiol was proved to protect rat annulus fibrosus cells against apoptosis induced by interleukin-1beta (IL-1beta). Estradiol 23-39 interleukin 1 beta Rattus norvegicus 137-145 25576195-3 2015 The purpose of this study was to further explore the effects of 17beta-estradiol on rat nucleus pulposus cells based on IL-1beta-induced apoptosis. Estradiol 64-80 interleukin 1 beta Rattus norvegicus 120-128 25576195-4 2015 TUNEL assay and Annexin V/PI double staining were used to detect apoptosis and revealed that IL-1beta induced notable apoptosis, which was reversed by 17beta-estradiol. Estradiol 151-167 interleukin 1 beta Rattus norvegicus 93-101 25576195-6 2015 However, all of the detected effects of IL-1beta were eliminated by 17beta-estradiol. Estradiol 68-84 interleukin 1 beta Rattus norvegicus 40-48 25576195-8 2015 Finally, 17beta-estradiol was proved to abolish the above negative effects of IL-1beta. Estradiol 9-25 interleukin 1 beta Rattus norvegicus 78-86 25576195-9 2015 In summary, this work presented that IL-1beta maybe induced apoptosis of rat nucleus pulposus cells, which was resisted by 17beta-estradiol by down-regulating MMP-3 and MMP-13 via a mitochondrial pathway. Estradiol 123-139 interleukin 1 beta Rattus norvegicus 37-45 25576195-10 2015 This research provides a novel insight into the anti-apoptotic effect of 17beta-estradiol on IL-1beta-induced cytotoxicity, and may potentially lead to a better understanding of the clinical effects of 17beta-estradiol, especially in terms of intervertebral disc degeneration. Estradiol 73-89 interleukin 1 beta Rattus norvegicus 93-101 25576195-10 2015 This research provides a novel insight into the anti-apoptotic effect of 17beta-estradiol on IL-1beta-induced cytotoxicity, and may potentially lead to a better understanding of the clinical effects of 17beta-estradiol, especially in terms of intervertebral disc degeneration. Estradiol 202-218 interleukin 1 beta Rattus norvegicus 93-101 25704036-8 2015 Altered levels of inflammatory cytokines like TNF-alpha, IL-1beta, IL-6 and nuclear transcriptional factor subunit NF-kappaB p65 were reverted to the normal level upon treatment with BAY 11-7082. 3-(4-methylphenylsulfonyl)-2-propenenitrile 183-194 interleukin 1 beta Rattus norvegicus 57-65 25450597-11 2015 IL-1beta in the hippocampus was increased at 4 h after isoflurane exposure. Isoflurane 55-65 interleukin 1 beta Rattus norvegicus 0-8 25625851-11 2015 Expression of IL-1beta and TLR-4 was attenuated in OH-F-treated WKY rats. oh-f 51-55 interleukin 1 beta Rattus norvegicus 14-22 25536420-4 2015 Moreover, treatment with curcumin markedly decreased the sub-arm of the UPR signaling protein such as phospho-double-stranded RNA-dependent protein kinase-like ER kinase, CCAAT/enhancer-binding protein homologous protein, tumor necrosis factor receptor-associated factor 2, and inositol-requiring enzyme1alpha; and inhibited tumor necrosis factor alpha, interleukin 1beta, phospho-p38 mitogen-activated protein kinase, and apoptosis signal-regulating kinase 1 in liver tissues of diabetic rats. Curcumin 25-33 interleukin 1 beta Rattus norvegicus 354-371 25667680-6 2015 Compared with the ischemia group, the levels of interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha) in the serum of rats in the ischemia + medium- and high-dose NaHS groups were significantly reduced, and the expression of intercellular adhesion molecule-1 (ICAM-1) mRNA and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) protein in the myocardial tissues of rats was significantly reduced. sodium bisulfide 182-186 interleukin 1 beta Rattus norvegicus 48-70 25667680-7 2015 In the ischemia + PPG group, the TNF-alpha, IL-1beta and IL-6 levels in the serum were significantly increased, the expression of ICAM-1 mRNA was increased, although without a significant difference, and the expression of NF-kappaB was increased. propargylglycine 18-21 interleukin 1 beta Rattus norvegicus 44-52 25546615-7 2015 Our data revealed decreases in the muscle concentrations of IL-1beta (35%), TNF-alpha (13%), IL-6 (48%), and TBARS (40%) in the melatonin-treated group compared with the control group. Melatonin 128-137 interleukin 1 beta Rattus norvegicus 60-68 25546615-8 2015 We also observed decreases in the plasma concentrations of IL-1beta (17%) in the melatonin-treated group. Melatonin 81-90 interleukin 1 beta Rattus norvegicus 59-67 25479948-0 2015 Curcumin attenuates CFA induced thermal hyperalgesia by modulation of antioxidant enzymes and down regulation of TNF-alpha, IL-1beta and IL-6. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 124-132 25620059-8 2015 In addition Genistein significantly suppressed the production of d-GalN-induced proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1beta. Genistein 12-21 interleukin 1 beta Rattus norvegicus 161-183 25524622-9 2015 Aliskiren treatment showed a significant down-regulatory effect on IL-1beta, iNOS and NFkB mRNA expression. aliskiren 0-9 interleukin 1 beta Rattus norvegicus 67-75 25541249-8 2015 Minocycline inhibited the SE-induced microglial activation and the increased production of interleukin-1beta and tumor necrosis factor-alpha in the hippocampal CA1 and the adjacent cortex, without affecting astrocytic activation. Minocycline 0-11 interleukin 1 beta Rattus norvegicus 91-140 25887642-10 2015 Also blood levels of inflammatory mediators (tumor necrosis factor-alpha, interleukin-1beta, interleukin-10, CXCL-2, interferon-gamma and high mobility group protein-1) were accentuated in propofol + CLP rats compared to the isoflurane + CLP group at the same time point (P <0.04). Propofol 189-197 interleukin 1 beta Rattus norvegicus 74-91 25559498-3 2015 In this study, we attempted to find a connection between interleukin-1beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1Ra) in trinitrobenzene sulfonic acid (TNBS)-induced chronic pancreatitis, and then the therapeutic effect of recombinant IL-1Ra was also detected in the CP model. Trinitrobenzenesulfonic Acid 136-165 interleukin 1 beta Rattus norvegicus 57-74 25559498-3 2015 In this study, we attempted to find a connection between interleukin-1beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1Ra) in trinitrobenzene sulfonic acid (TNBS)-induced chronic pancreatitis, and then the therapeutic effect of recombinant IL-1Ra was also detected in the CP model. Trinitrobenzenesulfonic Acid 136-165 interleukin 1 beta Rattus norvegicus 76-84 25559498-3 2015 In this study, we attempted to find a connection between interleukin-1beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1Ra) in trinitrobenzene sulfonic acid (TNBS)-induced chronic pancreatitis, and then the therapeutic effect of recombinant IL-1Ra was also detected in the CP model. Trinitrobenzenesulfonic Acid 167-171 interleukin 1 beta Rattus norvegicus 57-74 25559498-3 2015 In this study, we attempted to find a connection between interleukin-1beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1Ra) in trinitrobenzene sulfonic acid (TNBS)-induced chronic pancreatitis, and then the therapeutic effect of recombinant IL-1Ra was also detected in the CP model. Trinitrobenzenesulfonic Acid 167-171 interleukin 1 beta Rattus norvegicus 76-84 25497831-13 2015 Treatment with LMWH significantly decreased the expression of TNF-alpha, IL-1beta, HMGB1 and ICAM-1 in the lungs of ALI rats. Heparin, Low-Molecular-Weight 15-19 interleukin 1 beta Rattus norvegicus 73-81 25932110-7 2015 RESULTS: Pretreatment with pycnogenol could markedly decrease lung wet/dry ratio, lower myeloperoxidase (MPO) activity and total protein concentration and reduce the production of TNF-alpha, IL-6, IL-1beta and MIP-2 in the BALF in ventilator-induced lung injury rats. pycnogenols 27-37 interleukin 1 beta Rattus norvegicus 197-205 25220279-5 2015 Our results herein demonstrate that the development of oxaliplatin-induced mechano-hypersensitivity (allodynia and hyperalgesia) in rats is associated with the hyperactivation of astrocytes, but not microglial cells, increased production of pro-inflammatory and neuroexcitatory cytokines (TNF, IL-1beta), and reductions in the levels of anti-inflammatory/neuroprotective cytokines (IL-10, IL-4) in the dorsal horn of the spinal cord. Oxaliplatin 55-66 interleukin 1 beta Rattus norvegicus 294-302 25524407-8 2015 Second, gene knockdown of P2X7R with P2X7-siRNA or inhibition of P2X7R with BBG reduce the mRNA and protein expression of IL-1beta and TNF-alpha in the PVN of AMI rat. bbg 76-79 interleukin 1 beta Rattus norvegicus 122-130 25204979-8 2015 The treatments also reduced concentrations of interleukin-1beta, granulocyte colony-stimulating factor, and matrix metalloproteinase 2 in STZ-induced diabetic bone marrow supernatant and decreased the expression of NADPH oxidase 2, nitric oxide synthase 2, and nuclear factor-kappaB1 mRNA in bone marrow progenitor cells. Streptozocin 138-141 interleukin 1 beta Rattus norvegicus 46-63 25889169-14 2015 Treatment with minocycline significantly reduced levels of TNF-alpha and IL-1beta, and increased levels of TGF-beta, IL-10 and YM1. Minocycline 15-26 interleukin 1 beta Rattus norvegicus 73-81 25256150-10 2015 Moreover, COG and Dex significantly suppressed the production of TNF-alpha, IL-1beta, and IL-6 in serum. Dextromethorphan 18-21 interleukin 1 beta Rattus norvegicus 76-84 25001186-14 2015 CONCLUSION: In this study, we showed that trimetazidine treatment significantly decreases the levels of IL-1beta, amylase and lipase reduces pancreatic apoptosis and ameliorates the histopathological findings of cerulein-induced acute pancreatitis. Trimetazidine 42-55 interleukin 1 beta Rattus norvegicus 104-112 25449583-11 2015 Hippocampal IL-1beta levels were increased in LPS-treated adult but not preadolescent rats in response to formalin injection. Formaldehyde 106-114 interleukin 1 beta Rattus norvegicus 12-20 25446353-5 2015 alpha,beta-meATP induced increases in the local concentration of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin 1beta (IL-1beta), which were reduced by bradykinin antagonist. beta-meatp 6-16 interleukin 1 beta Rattus norvegicus 140-157 25338942-8 2015 NLRP3 inflammasome blocker glybenclamide pretreatment attenuated lung edema, inhibited the NLRP3, ASC, and caspase-1 activation, and reduced IL-1beta and IL-18 levels in BALF. Glyburide 27-40 interleukin 1 beta Rattus norvegicus 141-149 25338942-10 2015 In conclusion, paraquat can induce IL-1beta/IL-18 secretion via NLRP3-ASC-caspase-1 pathway, and the NLRP3 inflammasome is essential for paraquat-induced acute lung injury. Paraquat 15-23 interleukin 1 beta Rattus norvegicus 35-43 25592017-4 2015 The serum concentrations of interleukin (IL)-1beta and IL-6, which induce acute-phase proteins in the liver, were also significantly elevated on day 14 in the AsA-deficient group compared with the respective values in the control group. Ascorbic Acid 159-162 interleukin 1 beta Rattus norvegicus 28-50 25592017-5 2015 IL-1beta mRNA levels in the liver, spleen, and lung were increased by AsA deficiency. Ascorbic Acid 70-73 interleukin 1 beta Rattus norvegicus 0-8 25592017-6 2015 Moreover, on both days 14 and 18, the portal blood endotoxin concentration was significantly higher in the AsA-deficient group than in the control group, and a significant correlation between serum IL-1beta concentrations and portal endotoxin concentrations was found in AsA-deficient rats. Ascorbic Acid 107-110 interleukin 1 beta Rattus norvegicus 198-206 25592017-6 2015 Moreover, on both days 14 and 18, the portal blood endotoxin concentration was significantly higher in the AsA-deficient group than in the control group, and a significant correlation between serum IL-1beta concentrations and portal endotoxin concentrations was found in AsA-deficient rats. Ascorbic Acid 271-274 interleukin 1 beta Rattus norvegicus 198-206 25512333-0 2015 pyroGlu-Leu inhibits the induction of inducible nitric oxide synthase in interleukin-1beta-stimulated primary cultured rat hepatocytes. pyroglutamylleucine 0-11 interleukin 1 beta Rattus norvegicus 73-90 25512333-9 2015 IL-1beta stimulated the enhancement of NO production in hepatocytes and this effect was inhibited by pyroGlu-Leu. pyroglutamylleucine 101-112 interleukin 1 beta Rattus norvegicus 0-8 25059512-7 2015 These results suggest the possible role of glutamate excitotoxicity in neuronal death in the midline thalamic region following kainic acid-induced status epilepticus due to astrocytic EAAT2 downregulation following microglial activation showing upregulation of IL-1beta and iNOS. Glutamic Acid 43-52 interleukin 1 beta Rattus norvegicus 261-269 25059512-7 2015 These results suggest the possible role of glutamate excitotoxicity in neuronal death in the midline thalamic region following kainic acid-induced status epilepticus due to astrocytic EAAT2 downregulation following microglial activation showing upregulation of IL-1beta and iNOS. Kainic Acid 127-138 interleukin 1 beta Rattus norvegicus 261-269 25560579-7 2015 RESULTS: Co-administration of pioglitazone (40 mg/kg) with morphine not only attenuated morphine-induced tolerance, but also prevented the up-regulation of pro-inflammatory cytokines (tumour necrosis factor alpha, interleukin-1beta, interleukin-6) and nuclear factor-kappa B activity in the rat cerebral cortex. Pioglitazone 30-42 interleukin 1 beta Rattus norvegicus 214-231 25560579-7 2015 RESULTS: Co-administration of pioglitazone (40 mg/kg) with morphine not only attenuated morphine-induced tolerance, but also prevented the up-regulation of pro-inflammatory cytokines (tumour necrosis factor alpha, interleukin-1beta, interleukin-6) and nuclear factor-kappa B activity in the rat cerebral cortex. Morphine 59-67 interleukin 1 beta Rattus norvegicus 214-231 25993753-1 2015 OBJECTIVE: To study the effect of total saponins from Rhizoma Dioscoreae nipponicae (RDN) on the expression of stroma cell derived factor 1 (SDF1) and IKB kinase (IKK) in rIL-1beta induced fibroblast-like synoviocytes (FLS). Saponins 40-48 interleukin 1 beta Rattus norvegicus 171-180 25446353-5 2015 alpha,beta-meATP induced increases in the local concentration of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin 1beta (IL-1beta), which were reduced by bradykinin antagonist. beta-meatp 6-16 interleukin 1 beta Rattus norvegicus 159-167 25108038-11 2015 Propofol suppressed IL-1beta and TNF-alpha production, up-regulated the expression of GLT-1, decreased the concentration of glutamate in the hippocampus and attenuated the impairment of learning and memory induced by ECS. Propofol 0-8 interleukin 1 beta Rattus norvegicus 20-28 25240714-7 2015 Furthermore, PA markedly suppressed the level of proinflammatory cytokines (IL-1beta, TNF alpha and IL-6) and down regulated expressions of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (NOS-2) and nuclear factor kappaB (NF-kappaB) in MCAO group. perillyl alcohol 13-15 interleukin 1 beta Rattus norvegicus 76-84 25755829-10 2015 And melatonin showed an inhibition on TLR4/NF-kB signaling as well as IL-1beta and TNF-alpha production in the pulp of AP rats. Melatonin 4-13 interleukin 1 beta Rattus norvegicus 70-78 25589761-4 2015 Allopregnanolone attenuated ACTH responses to IL-1beta (500 ng/kg, i.v.) Pregnanolone 0-16 interleukin 1 beta Rattus norvegicus 46-54 25589761-6 2015 However, 3beta-diol normalized HPA axis responses to IL-1beta in PNS males. 3beta-diol 9-19 interleukin 1 beta Rattus norvegicus 53-61 26364660-5 2015 Pretreatment with RA significantly ameliorated pancreas histopathological changes, decreased amylase and lipase activities in serum, lowered myeloperoxidase activity in the pancreas, reduced systematic and pancreatic interleukin-1 beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) levels, and inhibited NF-kappaB translocation in pancreas. rosmarinic acid 18-20 interleukin 1 beta Rattus norvegicus 217-235 26581384-6 2015 We observed an age-dependent increase in the basal density of IL-1beta/NeuN-ir cells in CeA and MeA in P90 vs. P360 and P360 vs. P720 rats. cea 88-91 interleukin 1 beta Rattus norvegicus 62-70 26581384-9 2015 Moreover, chronic HL-OF led to an increase in the density of IL-1beta-ir neurons in relation to acute HL-OF in the CeA and MeA of both P360 and P720 rats. cea 115-118 interleukin 1 beta Rattus norvegicus 61-69 26581384-9 2015 Moreover, chronic HL-OF led to an increase in the density of IL-1beta-ir neurons in relation to acute HL-OF in the CeA and MeA of both P360 and P720 rats. mea 123-126 interleukin 1 beta Rattus norvegicus 61-69 26364660-5 2015 Pretreatment with RA significantly ameliorated pancreas histopathological changes, decreased amylase and lipase activities in serum, lowered myeloperoxidase activity in the pancreas, reduced systematic and pancreatic interleukin-1 beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) levels, and inhibited NF-kappaB translocation in pancreas. rosmarinic acid 18-20 interleukin 1 beta Rattus norvegicus 237-245 25947920-11 2015 The IL-1beta and TNF-alpha levels were decreased in the MTX+OLME 5.0 mg/kg (p<0.01 and p<0.05, respectively) compared with the MTX-alone group. Methotrexate 56-59 interleukin 1 beta Rattus norvegicus 4-12 25420023-5 2015 IL-1beta, IL-6, and IL-10 mRNA levels were significantly decreased in the periwound skin around the wounds and granulation tissue covered with HCF. hcf 143-146 interleukin 1 beta Rattus norvegicus 0-8 25266050-0 2015 A new flavanone and other flavonoids from green perilla leaf extract inhibit nitric oxide production in interleukin 1beta-treated hepatocytes. flavanone 6-15 interleukin 1 beta Rattus norvegicus 104-121 25266050-0 2015 A new flavanone and other flavonoids from green perilla leaf extract inhibit nitric oxide production in interleukin 1beta-treated hepatocytes. Flavonoids 26-36 interleukin 1 beta Rattus norvegicus 104-121 25266050-0 2015 A new flavanone and other flavonoids from green perilla leaf extract inhibit nitric oxide production in interleukin 1beta-treated hepatocytes. Nitric Oxide 77-89 interleukin 1 beta Rattus norvegicus 104-121 25266050-6 2015 Shisoflavanone A and the other constituents (except 7) significantly inhibited nitric oxide production in interleukin 1beta-stimulated rat hepatocytes, which have been used to monitor the anti-inflammatory effects of herbal constituents. shisoflavanone A 0-16 interleukin 1 beta Rattus norvegicus 106-123 25266050-6 2015 Shisoflavanone A and the other constituents (except 7) significantly inhibited nitric oxide production in interleukin 1beta-stimulated rat hepatocytes, which have been used to monitor the anti-inflammatory effects of herbal constituents. Nitric Oxide 79-91 interleukin 1 beta Rattus norvegicus 106-123 26287758-9 2015 RESULTS: Brain and erythrocyte lipid peroxidation levels and plasma IL-1beta and IL-4 levels were high in the STZ group, although they were low in melatonin and selenium treatments. Streptozocin 110-113 interleukin 1 beta Rattus norvegicus 68-76 25294342-7 2015 L-NAME induced an increase in MAP and plasma IL-1beta. NG-Nitroarginine Methyl Ester 0-6 interleukin 1 beta Rattus norvegicus 45-53 25947920-11 2015 The IL-1beta and TNF-alpha levels were decreased in the MTX+OLME 5.0 mg/kg (p<0.01 and p<0.05, respectively) compared with the MTX-alone group. olmesartan 60-64 interleukin 1 beta Rattus norvegicus 4-12 26165866-6 2015 Subsequently, NaHS significantly suppressed the expression of tumor necrosis factor (TNF)-alpha, interleukin-1beta (IL-1beta) and cyclooxygenase-2 (COX-2) in rat hippocampus following Abeta administration. sodium bisulfide 14-18 interleukin 1 beta Rattus norvegicus 97-114 26584300-4 2015 Thus, in this report we examined the effects of nefiracetam (NEF), a pyrrolidone derivative, on the levels of IL-1beta, IL-6 and TNF-alpha, and expression of GAT-1 and GAT-3 in the parietal cortex, hippocampus and amygdala using a rat model of post-ischemic nonconvulsive seizure (NCS). nefiracetam 48-59 interleukin 1 beta Rattus norvegicus 110-118 26159236-13 2015 The mechanisms underlying protective effects of H2S were associated with the inhibition of CA/ CPR-induced inflammation reactions by reducing IL-1beta, IL-6 and TNF-alpha, and concomitantly inhibiting the activation and infiltration of neutrophils. Hydrogen Sulfide 48-51 interleukin 1 beta Rattus norvegicus 142-150 25613062-9 2015 In primary cultured rat chondrocytes, pretreatment with nicotine suppressed both p38, extracellular regulated kinase (Erk) 1/2 and c-Jun-N-terminal kinase (JNK) mitogen-activated protein kinases (MAPK) phosphorylation and phosphorylated nuclear factor-kappa B (NF-kappaB) p65 activation induced by MIA- or IL-1beta, and these effects were also reversed by MLA. Nicotine 56-64 interleukin 1 beta Rattus norvegicus 306-314 25945106-7 2015 DFE, DPE, and their combination with coffee attenuated the elevated levels of inflammatory cytokines including tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta. dpe 5-8 interleukin 1 beta Rattus norvegicus 159-176 26591203-1 2015 It was established in experiments on noninbred albino rats that acute intoxication with malathion (0.75 LD50) reduced the function of Th1 cells more significantly than the function of Th2 lymphocyte, decreases the activity of B cells and NK cells, blood levels of TNFa, IL-1b and IL-6, IFN-g, IL-2, and IL-4, while not significantly affecting the concentration of IL-10 and IL-13. Malathion 88-97 interleukin 1 beta Rattus norvegicus 270-275 27051922-9 2015 In case of immunodeficiency caused by cyclophosphamide, there was a significant decrease in IL-1beta, IL-4 and IL-6, but the introduction of phenotropil largely restored their levels. Cyclophosphamide 38-54 interleukin 1 beta Rattus norvegicus 92-100 27051922-11 2015 Under these conditions, phenotropil restored the normal levels of IL-1beta, IL-6 and caused an increase in the level of IL-4. 4-phenylpiracetam 24-35 interleukin 1 beta Rattus norvegicus 66-74 25945106-7 2015 DFE, DPE, and their combination with coffee attenuated the elevated levels of inflammatory cytokines including tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta. 1,1-difluoroethane 0-3 interleukin 1 beta Rattus norvegicus 159-176 26279449-14 2015 GAG synthesis and type II collagen were decreased in both the IL-1beta groups and the Osthole groups, and significantly reduced by Osthole plus IL-1beta. Glycosaminoglycans 0-3 interleukin 1 beta Rattus norvegicus 62-70 26279449-14 2015 GAG synthesis and type II collagen were decreased in both the IL-1beta groups and the Osthole groups, and significantly reduced by Osthole plus IL-1beta. Glycosaminoglycans 0-3 interleukin 1 beta Rattus norvegicus 144-152 24812154-8 2015 Pretreatment with Ad-RUNRF2 and RU486 also strongly suppressed the PQ-induced activation of nuclear factor kappaB (NF-kappaB) and decreased the levels of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6). Mifepristone 32-37 interleukin 1 beta Rattus norvegicus 196-213 26273316-6 2015 Moreover, reductions in serum interleukins IL-1beta and IL-6 levels were also observed in BDL rats treated with swertianlarin (P < 0.05). swertianlarin 112-125 interleukin 1 beta Rattus norvegicus 43-51 26151083-8 2015 Moreover, 1,25(OH)2D3 significantly downregulated the expression of TLR4, NF-kappaB, and the inflammatory cytokines TNF-alpha, IL-1beta, and IL-6. Calcitriol 10-21 interleukin 1 beta Rattus norvegicus 127-135 24812154-8 2015 Pretreatment with Ad-RUNRF2 and RU486 also strongly suppressed the PQ-induced activation of nuclear factor kappaB (NF-kappaB) and decreased the levels of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6). Mifepristone 32-37 interleukin 1 beta Rattus norvegicus 215-223 24812154-8 2015 Pretreatment with Ad-RUNRF2 and RU486 also strongly suppressed the PQ-induced activation of nuclear factor kappaB (NF-kappaB) and decreased the levels of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6). Paraquat 67-69 interleukin 1 beta Rattus norvegicus 196-213 24812154-8 2015 Pretreatment with Ad-RUNRF2 and RU486 also strongly suppressed the PQ-induced activation of nuclear factor kappaB (NF-kappaB) and decreased the levels of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6). Paraquat 67-69 interleukin 1 beta Rattus norvegicus 215-223 25411096-10 2015 It was ascertained that, compared to the diabetic group, safranal decreased the inflammation both in the plasma and pancreas tissue, by reducing the TNF-alpha and IL-1beta levels in particular. safranal 57-65 interleukin 1 beta Rattus norvegicus 163-171 26466641-10 2015 We also observed that treatment with triptolide significantly decreases serum levels of IL-1beta and IL-18, and may exerted anti-inflammatory effects by down-regulating NLRP3 and TLR4 expression. triptolide 37-47 interleukin 1 beta Rattus norvegicus 88-96 25428204-5 2015 A significant decrease in interleukin 1beta and tumor necrosis factor alpha occurred in tendons treated with phonophoresis+diclophenac+GNPs. Diclofenac 123-134 interleukin 1 beta Rattus norvegicus 26-75 25412187-0 2015 Exogenous H2S protects H9c2 cardiac cells against high glucose-induced injury and inflammation by inhibiting the activation of the NF-kappaB and IL-1beta pathways. Hydrogen Sulfide 10-13 interleukin 1 beta Rattus norvegicus 145-153 25755716-9 2015 Our results showed that pretreatment with shikonin (4 muM) inhibited cytotoxicity and apoptosis induced by IL-1beta (10 ng/ml) in chondrocytes. shikonin 42-50 interleukin 1 beta Rattus norvegicus 107-115 25755716-10 2015 Shikonin pretreatment also decreased the activity of IL-1beta that decreased Bcl-2 expression and levels of p-PI3K and p-Akt, and increased Bax expression, cytochrome c release, and caspase-3 activation. shikonin 0-8 interleukin 1 beta Rattus norvegicus 53-61 25755716-12 2015 These data suggested that shikonin may protect chondrocytes from apoptosis induced by IL-1beta through the PI3K/Akt signaling pathway, by deactivating caspase-3. shikonin 26-34 interleukin 1 beta Rattus norvegicus 86-94 25412187-0 2015 Exogenous H2S protects H9c2 cardiac cells against high glucose-induced injury and inflammation by inhibiting the activation of the NF-kappaB and IL-1beta pathways. Glucose 55-62 interleukin 1 beta Rattus norvegicus 145-153 25412187-2 2015 We have previously demonstrated that exogenous hydrogen sulfide (H2S) protects cardiomyocytes against high glucose (HG)-induced injury by inhibiting the activity of p38 mitogen-activated protein kinase (MAPK), which can activate the NF-kappaB pathway and induce interleukin (IL)-1beta production. Hydrogen Sulfide 47-63 interleukin 1 beta Rattus norvegicus 262-284 25412187-2 2015 We have previously demonstrated that exogenous hydrogen sulfide (H2S) protects cardiomyocytes against high glucose (HG)-induced injury by inhibiting the activity of p38 mitogen-activated protein kinase (MAPK), which can activate the NF-kappaB pathway and induce interleukin (IL)-1beta production. Hydrogen Sulfide 65-68 interleukin 1 beta Rattus norvegicus 262-284 25412187-2 2015 We have previously demonstrated that exogenous hydrogen sulfide (H2S) protects cardiomyocytes against high glucose (HG)-induced injury by inhibiting the activity of p38 mitogen-activated protein kinase (MAPK), which can activate the NF-kappaB pathway and induce interleukin (IL)-1beta production. Glucose 107-114 interleukin 1 beta Rattus norvegicus 262-284 25412187-3 2015 In the present study, we aimed to investigate the hypothesis that exogenous H2S protects cardiomyocytes against HG-induced injury and inflammation through the inhibition of the NF-kappaB/IL-1beta pathway. Hydrogen Sulfide 76-79 interleukin 1 beta Rattus norvegicus 187-195 25412187-7 2015 In addition, pre-treatment of the cells with NaHS or PDTC ameliorated the HG-induced inflammatory response, leading to a decrease in the levels of IL-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha). sodium bisulfide 45-49 interleukin 1 beta Rattus norvegicus 147-155 25412187-7 2015 In addition, pre-treatment of the cells with NaHS or PDTC ameliorated the HG-induced inflammatory response, leading to a decrease in the levels of IL-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha). pyrrolidine dithiocarbamic acid 53-57 interleukin 1 beta Rattus norvegicus 147-155 25412187-9 2015 In conclusion, the present study presents novel mechanistic evidence that exogenous H2S protects H9c2 cardiac cells against HG-induced inflammation and injury, including cytotoxicity, apoptosis, overproduction of ROS and the dissipation of MMP, by inhibiting the NF-kappaB/IL-1beta pathway. Hydrogen Sulfide 84-87 interleukin 1 beta Rattus norvegicus 273-281 25854530-6 2015 RESULTS: Treatment with resveratrol (100 muM, 24 hours) in CVECs from SHRSP significantly decreased the interleukin (IL)-1beta-induced monocyte chemoattractant protein-1 (MCP-1) mRNA expression levels and p50 and p65 protein levels in the nuclear fraction. Resveratrol 24-35 interleukin 1 beta Rattus norvegicus 104-126 25854530-8 2015 Resveratrol slightly, but not significantly, decreased the plasma levels of IL-1beta and MCP-1 compared with that observed in the control group. Resveratrol 0-11 interleukin 1 beta Rattus norvegicus 76-84 25854530-9 2015 In addition, resveratrol decreased the IL-1beta and MCP-1 mRNA expression levels in the brain versus the control animals. Resveratrol 13-24 interleukin 1 beta Rattus norvegicus 39-47 26756424-9 2015 and flunixin (2.5 mg/kg daily, s.c.) decreased serum LDH, ALP, interleukin (IL)-1beta, and tumor necrosis factor-alpha levels, as well as colonic MPO and lipid peroxide levels, whereas increased colonic prostaglandin E2 and IL-10 concentrations were observed. flunixin 4-12 interleukin 1 beta Rattus norvegicus 63-85 25160751-5 2015 In cultured rat hepatocytes, GSK3 inhibitors decreased IL-1beta mediated nitric oxide (NO) production and iNOS protein expression, while the phosphatidylinositol 3-kinase (PI3K)/Akt pathway inhibitor LY294002 increased the cytokine-mediated NO production and iNOS expression. Nitric Oxide 73-85 interleukin 1 beta Rattus norvegicus 55-63 26245187-8 2015 Co-incubation with U0126 or BoNT-A retained the increased expression of SNAP-25, while it decreased the IL-1beta immunoreactivity in neurons. U 0126 19-24 interleukin 1 beta Rattus norvegicus 104-112 26245187-8 2015 Co-incubation with U0126 or BoNT-A retained the increased expression of SNAP-25, while it decreased the IL-1beta immunoreactivity in neurons. bont-a 28-34 interleukin 1 beta Rattus norvegicus 104-112 24954678-10 2015 Results revealed that cadmium significantly increased IL-1beta, TNF alpha, IL-6 and IL-10, beside peripheral neutrophils count, while the IFN-gamma and lymphocytes were decreased in rat sera. Cadmium 22-29 interleukin 1 beta Rattus norvegicus 54-62 25759838-6 2015 Increased protein levels of cytokine-induced neutrophil chemoattractant (CINC-3) and interleukin-1 beta (IL-1beta) were found after 30 or 60 min of helium inhalation, in comparison to control. Helium 148-154 interleukin 1 beta Rattus norvegicus 85-103 25759838-6 2015 Increased protein levels of cytokine-induced neutrophil chemoattractant (CINC-3) and interleukin-1 beta (IL-1beta) were found after 30 or 60 min of helium inhalation, in comparison to control. Helium 148-154 interleukin 1 beta Rattus norvegicus 105-113 25759838-7 2015 30 min of helium increased mRNA levels of CINC-3, IL-1beta, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) in myocardial tissue not directly subjected to ischemia/reperfusion. Helium 10-16 interleukin 1 beta Rattus norvegicus 50-58 24954678-14 2015 Selenium in combination with cadmium, significantly improved the elevation of serum IL-1beta, IL-6, TNF alpha, IL-10 and malondialdehyde in addition to enhancing the antioxidant enzyme activities of GSH, CAT, GPx and SOD. Selenium 0-8 interleukin 1 beta Rattus norvegicus 84-92 24954678-14 2015 Selenium in combination with cadmium, significantly improved the elevation of serum IL-1beta, IL-6, TNF alpha, IL-10 and malondialdehyde in addition to enhancing the antioxidant enzyme activities of GSH, CAT, GPx and SOD. Cadmium 29-36 interleukin 1 beta Rattus norvegicus 84-92 25878401-4 2015 Results showed that hydrogen-rich saline attenuated the following: (1) serum Cr and BUN, (2) pancreatic and renal pathological injuries, (3) renal MDA, (4) renal MPO, (5) serum IL-1beta, IL-6, and renal TNF-alpha, HMGB1, and (6) tyrosine nitration, IkappaB degradation, and NF-kappaB activation in renal tissues. Hydrogen 20-28 interleukin 1 beta Rattus norvegicus 177-185 25070591-7 2015 In comparisons with control (IL-1beta: 100.5 +- 92.5 / COX-2: 180.1 +- 97.1 / PGE2: 187.8 +- 128.8) IL-1beta exhibited (mean +- SD) near-normal level (p > 0.05) at LASER 3 (142.0 +- 162.4). Dinoprostone 78-82 interleukin 1 beta Rattus norvegicus 100-108 25896311-8 2015 The administration of a PPAR-gamma inhibitor, BADGE, halted the reduction of IL-1beta and TNF-alpha in the glycyrrhizin groups. Glycyrrhizic Acid 107-119 interleukin 1 beta Rattus norvegicus 77-85 25729217-11 2015 Allicin reduced the body weight loss of trinitrobenzenesulfonic acid-induced rats, histological score, serum TNF-alpha and IL-1beta levels, and colon IL-1beta mRNA level and induced serum IL-4 level, particularly in combination with mesalazine. allicin 0-7 interleukin 1 beta Rattus norvegicus 123-131 25729217-11 2015 Allicin reduced the body weight loss of trinitrobenzenesulfonic acid-induced rats, histological score, serum TNF-alpha and IL-1beta levels, and colon IL-1beta mRNA level and induced serum IL-4 level, particularly in combination with mesalazine. allicin 0-7 interleukin 1 beta Rattus norvegicus 150-158 25878401-4 2015 Results showed that hydrogen-rich saline attenuated the following: (1) serum Cr and BUN, (2) pancreatic and renal pathological injuries, (3) renal MDA, (4) renal MPO, (5) serum IL-1beta, IL-6, and renal TNF-alpha, HMGB1, and (6) tyrosine nitration, IkappaB degradation, and NF-kappaB activation in renal tissues. Sodium Chloride 34-40 interleukin 1 beta Rattus norvegicus 177-185 26617437-0 2015 DMA(V) in Drinking Water Activated NF-kappaB Signal Pathway and Increased TGF-beta and IL-1beta Expressions in Bladder Epithelial Cells of Rats. N-myristoyl-alaninol 0-3 interleukin 1 beta Rattus norvegicus 87-95 26417153-5 2015 Treatment with IL-4 markedly blocked IL-1beta-induced increase in PGE2 and CORT levels. Dinoprostone 66-70 interleukin 1 beta Rattus norvegicus 37-45 26273145-7 2015 In DEX group, mortality was lower, histology change was minor, DAO, and D-lactate levels were reduced, and occludin expression was increased; the expressions of TNF-alpha, IL-1beta, IL-6, and TLR4 were also decreased in DEX group. Dexmedetomidine 3-6 interleukin 1 beta Rattus norvegicus 172-180 26617437-6 2015 In addition, DMA(V) treated rats exhibited significantly increased inflammatory factor TGF-beta immunoreactivity in bladder epithelium and IL-1beta secretion in urine. N-myristoyl-alaninol 13-16 interleukin 1 beta Rattus norvegicus 139-147 26617437-7 2015 These data suggest that DMA(V) could activate NF-kappaB signal pathway and increase TGF-beta and IL-1beta expressions in bladder epithelial cells of rats. N-myristoyl-alaninol 24-27 interleukin 1 beta Rattus norvegicus 97-105 26648661-6 2015 What was more, AC-Rsv and Rsv treatment reduced the secretion of TNF-alpha, IL-6, and IL-1beta in lungs and NR8383 cells, respectively. 3,5,4'-tri-O-acetylresveratrol 15-21 interleukin 1 beta Rattus norvegicus 86-94 25445360-10 2015 Additionally, the activation of astrocytes, the phosphorylation of extracellular signal-regulated kinase 42/44 (ERK(42/44)) and the expressions of TNFalpha and IL-1beta were inhibited significantly by rosuvastatin. Rosuvastatin Calcium 201-213 interleukin 1 beta Rattus norvegicus 160-168 25765436-7 2015 Data obtained 45 days after EAE induction showed that DHT exerts a beneficial effect on clinical scores, coupled with decreased gliosis (i.e. glial fibrillary acidic protein and major histocompatibility complex of class II staining) and inflammation (i.e. translocator protein 18 kDa, interleukin-1beta, Toll-like receptor 4 and nuclear factor-kappaB expression) in the spinal cord. Dihydrotestosterone 54-57 interleukin 1 beta Rattus norvegicus 285-302 24945989-7 2015 In addition, cod liver oil results in reduction of hepatic TNF-alpha, IL-1beta, CRP, TGF-beta1, and caspase-3 when compared with the sodium nitrite group. Cod Liver Oil 13-26 interleukin 1 beta Rattus norvegicus 70-78 25653737-7 2015 Moreover, administration of dexmedetomidine induced downregulation of IL-1beta on mRNA and protein level in the developing rat brain. Dexmedetomidine 28-43 interleukin 1 beta Rattus norvegicus 70-78 25455865-9 2015 In addition, plasma levels of tumor necrosis factor-alpha and interleukin-1 beta were increased by CUMS, but were restored to normal by resveratrol. Resveratrol 136-147 interleukin 1 beta Rattus norvegicus 62-80 26202209-7 2015 RESULTS: GEN induced a raise in the levels of serum Cr, BUN and also the levels of MDA, IL-6, IL-18, IL-1beta and TNF-alpha with decease in GSH, SOD, GPx and IL-10 in the kidney (p < 0.05). Gentamicins 9-12 interleukin 1 beta Rattus norvegicus 101-109 25551197-9 2014 RESULTS: OUA pretreatment decreased mRNA levels of the pro-inflammatory cytokines, inducible nitric oxide synthase (iNOS) and IL-1beta, which are activated by LPS in the hippocampus, but with no effect on serum measures of these factors. Ouabain 9-12 interleukin 1 beta Rattus norvegicus 126-134 25548106-11 2014 Neither oleoylethanolamide nor palmitoylethanolamide modified plasma corticosterone levels after lipopolysaccharide, but both acylethanolamides reduced the expression of hypothalamic markers of thermoregulation interleukin-1beta, cyclooxygenase-2, and prostaglandin E2, and potentiated the hypothermic response after lipopolysaccharide. acylethanolamides 126-143 interleukin 1 beta Rattus norvegicus 211-228 25598708-8 2014 RESULTS AND DISCUSSION: The LPS resulted in induction of systemic inflammation as evidenced by increased levels of IL-1beta in plasma of LPS-treated rats compared to their non-treated control counterparts. lps 28-31 interleukin 1 beta Rattus norvegicus 115-123 25598708-8 2014 RESULTS AND DISCUSSION: The LPS resulted in induction of systemic inflammation as evidenced by increased levels of IL-1beta in plasma of LPS-treated rats compared to their non-treated control counterparts. lps 137-140 interleukin 1 beta Rattus norvegicus 115-123 25598708-10 2014 However, the elevation of IL-1beta levels in plasma of LPS-induced rats consuming either RPO or rooibos alone were paralleled with increased levels of the anti-inflammatory cytokine, IL-10. lps 55-58 interleukin 1 beta Rattus norvegicus 26-34 25671045-10 2014 Nicotine treatment led to a decrease of the effect of the burn trauma with significantly lower concentrations of tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 compared to the trauma group. Nicotine 0-8 interleukin 1 beta Rattus norvegicus 142-160 25593509-0 2014 The effect of puerarin against IL-1beta-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2). puerarin 14-22 interleukin 1 beta Rattus norvegicus 31-39 25593509-3 2014 This study extensively evaluated the protective effect of puerarin, a major active component extracted from the traditional herb Radix puerariae, against IL-1beta-induced cell dysfunction in TR-iBRB2 cells, a retinal capillary endothelial cell line. puerarin 58-66 interleukin 1 beta Rattus norvegicus 154-162 25593509-6 2014 RESULTS: Our data showed that puerarin attenuated IL-1beta-mediated leukostasis and cell apoptosis in TR-iBRB2 cells. puerarin 30-38 interleukin 1 beta Rattus norvegicus 50-58 25593509-7 2014 Furthermore, puerarin strikingly prevented IL-1beta-induced molecular events of the upstream and downstream signaling pathways involved in this cellular process. puerarin 13-21 interleukin 1 beta Rattus norvegicus 43-51 25446642-8 2014 Furthermore, the LPS-induced increase of IL-1beta mRNA levels was significantly blunted in the frontal cortex of alcohol-exposed female rats. Alcohols 113-120 interleukin 1 beta Rattus norvegicus 41-49 25481391-12 2014 Kolaviron treatment of diabetic rats also suppressed renal IL-1beta. kolaviron 0-9 interleukin 1 beta Rattus norvegicus 59-67 25481391-13 2014 The beneficial effects of kolaviron on diabetes-induced kidney injury may be due to its inhibitory action on oxidative stress, IL-1beta production and apoptosis. kolaviron 26-35 interleukin 1 beta Rattus norvegicus 127-135 25501918-2 2014 Resveratrol can prevent cells from p53- and reactive oxygen species-dependent apoptosis induced by interleukin-1b. Resveratrol 0-11 interleukin 1 beta Rattus norvegicus 99-113 25501918-2 2014 Resveratrol can prevent cells from p53- and reactive oxygen species-dependent apoptosis induced by interleukin-1b. Reactive Oxygen Species 44-67 interleukin 1 beta Rattus norvegicus 99-113 24980862-6 2014 Levels of activated microglia, activated NF-kappaB, and proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) in lumber spinal cord were elevated in rats following CCI induction, and catalpol significantly inhibited these effects. CCI 164-167 interleukin 1 beta Rattus norvegicus 83-91 25132256-8 2014 RESULTS: Compared to normal control rats, TNBS+IP saline had significant weight loss, increased macroscopic and microscopic scores, higher disease activity index (DAI) up-regulation of TNF-alpha, IL-1beta and NFATc4 mRNA expression and up-regulation of TNF-alpha and IL-1beta protein expression. ip 47-49 interleukin 1 beta Rattus norvegicus 196-204 25132256-8 2014 RESULTS: Compared to normal control rats, TNBS+IP saline had significant weight loss, increased macroscopic and microscopic scores, higher disease activity index (DAI) up-regulation of TNF-alpha, IL-1beta and NFATc4 mRNA expression and up-regulation of TNF-alpha and IL-1beta protein expression. ip 47-49 interleukin 1 beta Rattus norvegicus 267-275 25132256-8 2014 RESULTS: Compared to normal control rats, TNBS+IP saline had significant weight loss, increased macroscopic and microscopic scores, higher disease activity index (DAI) up-regulation of TNF-alpha, IL-1beta and NFATc4 mRNA expression and up-regulation of TNF-alpha and IL-1beta protein expression. Sodium Chloride 50-56 interleukin 1 beta Rattus norvegicus 196-204 25132256-8 2014 RESULTS: Compared to normal control rats, TNBS+IP saline had significant weight loss, increased macroscopic and microscopic scores, higher disease activity index (DAI) up-regulation of TNF-alpha, IL-1beta and NFATc4 mRNA expression and up-regulation of TNF-alpha and IL-1beta protein expression. Sodium Chloride 50-56 interleukin 1 beta Rattus norvegicus 267-275 25132256-9 2014 Compared to TNBS+IP saline, treatment with APS or dexamethasone significantly reduced DAI, partially but significantly prevented TNBS colitis-induced weight loss and improved both macroscopic and microscopic scores; high dose APS or dexamethasone significantly down-regulated TNF-alpha and IL-1beta expressions (both mRNA and protein) and up-regulated NFATc4 mRNA and protein expression. Dexamethasone 50-63 interleukin 1 beta Rattus norvegicus 290-298 24920394-8 2014 Low-dose treatment of MTX decreased the level of IL-1beta and MCP-1 on day 14 and activation of NF-kappaB in liver without significant effect on other parameters. Methotrexate 22-25 interleukin 1 beta Rattus norvegicus 49-57 24920394-9 2014 N-f-5HT and MTX combination showed both the anti-arthritic (hind paw volume and arthritic score) and anti-inflammatory effect (plasmatic levels of IL-1beta, IL-17, MCP-1, CRP, and activation of NF-kappaB in liver). n-f-5ht 0-7 interleukin 1 beta Rattus norvegicus 147-155 24920394-9 2014 N-f-5HT and MTX combination showed both the anti-arthritic (hind paw volume and arthritic score) and anti-inflammatory effect (plasmatic levels of IL-1beta, IL-17, MCP-1, CRP, and activation of NF-kappaB in liver). Methotrexate 12-15 interleukin 1 beta Rattus norvegicus 147-155 25466266-5 2014 UA administration markedly decreased the expressions of TLR4 pathway-related agents, such as intercellular adhesion molecule-1 (ICAM-1), TLR4, nuclear factor-kappaB (NF-kappaB) P65, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9. ursolic acid 0-2 interleukin 1 beta Rattus norvegicus 182-199 24839089-5 2014 The results showed that rosiglitazone attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), and the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) in a dose-dependent manner. Rosiglitazone 24-37 interleukin 1 beta Rattus norvegicus 217-234 24839089-5 2014 The results showed that rosiglitazone attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), and the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) in a dose-dependent manner. Rosiglitazone 24-37 interleukin 1 beta Rattus norvegicus 236-244 25445962-9 2014 RESULTS: Gastric emptying was delayed significantly in diabetic rats and improved significantly with SB203580; high glucose significantly activated p38 MAPK and increased the expression of iNOS, TNF-alpha and IL-1beta. Glucose 116-123 interleukin 1 beta Rattus norvegicus 209-217 25445962-10 2014 The administration of SB203580 led to a significant decrease in the activation of p38 MAPK and the expression of iNOS, TNF-alpha and IL-1beta. SB 203580 22-30 interleukin 1 beta Rattus norvegicus 133-141 25445962-11 2014 CONCLUSIONS: Inflammation was associated with the development of delayed gastric emptying, and blockade of p38 MAPK pathway with SB203580 ameliorates delayed gastric emptying in diabetic rats, at least in part, by inhibiting the expression of iNOS, TNF-a and IL-1beta. SB 203580 129-137 interleukin 1 beta Rattus norvegicus 259-267 25357233-11 2014 The PQ group had significantly higher pulmonary histology scores, wet-to-dry weight ratios and phosphorylated p-p38 MAPK levels, as well as higher IL-1beta and TNF-alpha levels in BALF and lung tissues, that did the SB + PQ and control groups (p < 0.05, all). Paraquat 4-6 interleukin 1 beta Rattus norvegicus 147-155 25466266-5 2014 UA administration markedly decreased the expressions of TLR4 pathway-related agents, such as intercellular adhesion molecule-1 (ICAM-1), TLR4, nuclear factor-kappaB (NF-kappaB) P65, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9. ursolic acid 0-2 interleukin 1 beta Rattus norvegicus 201-209 24617291-7 2014 Also ALA decreased IL-1beta and Caspase 3 levels that increased in SNC group. Alanine 5-8 interleukin 1 beta Rattus norvegicus 19-27 26914760-2 2014 Previously we demonstrated, in vitro, that by delivering interleukin-1 receptor antagonist (IL-1ra) from poly(lactic co-glycolic acid) (PLGA) microspheres, we could attenuate the degradative effects of IL-1beta on the nucleus pulposus (NP) for up to 20 days. Polylactic Acid-Polyglycolic Acid Copolymer 105-134 interleukin 1 beta Rattus norvegicus 202-210 26914760-9 2014 Glycosaminoglycan content for discs injected with IL-1beta alone was significantly lower than for intact controls. Glycosaminoglycans 0-17 interleukin 1 beta Rattus norvegicus 50-58 25480578-0 2014 Rapamycin ameliorates neuropathic pain by activating autophagy and inhibiting interleukin-1beta in the rat spinal cord. Sirolimus 0-9 interleukin 1 beta Rattus norvegicus 78-95 26914760-10 2014 For discs injected with IL-1beta along with IL-1ra microspheres, glycosaminoglycan content was not significantly different from intact controls. Glycosaminoglycans 65-82 interleukin 1 beta Rattus norvegicus 24-32 25480578-6 2014 Our results showed that rapamycin could ameliorate neuropathic pain by activating autophagy and inhibiting IL-1beta in the spinal cord. Sirolimus 24-33 interleukin 1 beta Rattus norvegicus 107-115 25238748-11 2014 In the presence of IL-1beta, Ni(PipNONO)Cl inhibited cyclooxygenase-2 and inducible nitric oxide synthase upregulation, and reduced endothelial permeability and the platelet and monocyte adhesion markers CD31 and CD40 at the plasma membrane. ni(pipnono)cl 29-42 interleukin 1 beta Rattus norvegicus 19-27 25182346-2 2014 Compelling evidence suggest that neuro-immune activation (pro-inflammatory cytokines including IL-1beta, IL-6 and TNF) as well as neuro-inflammation have been shown to mediate the development of morphine analgesic tolerance. Morphine 195-203 interleukin 1 beta Rattus norvegicus 95-103 25270428-9 2014 High concentrations of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and myeloperoxidase activity caused by IR were significantly decreased in kidney tissue with fluoxetine. Fluoxetine 179-189 interleukin 1 beta Rattus norvegicus 52-69 25141943-5 2014 The rats on a sucrose diet exhibited increased body weight, abdominal fat, triglycerides, GTT, and plasma levels of insulin, adiponectin, leptin, resistin, IL-6, IL-1beta, tumor necrosis factor-alpha (TNF-alpha) and IFN-gamma, upregulated lung IL-6, IL-1beta, TNF-alpha and IFN-gamma, showing hyperplastic bronchial and alveolar epithelium. Sucrose 14-21 interleukin 1 beta Rattus norvegicus 250-258 25271258-4 2014 The compound blocked the ATP-induced current and Bz-ATP [2"(3")-O-(4-benzoylbenzoyl)adenosine-5"-triphosphate tri(triethylammonium)]-induced release of IL-1beta in a concentration-dependent manner. Adenosine Triphosphate 25-28 interleukin 1 beta Rattus norvegicus 152-160 25271258-4 2014 The compound blocked the ATP-induced current and Bz-ATP [2"(3")-O-(4-benzoylbenzoyl)adenosine-5"-triphosphate tri(triethylammonium)]-induced release of IL-1beta in a concentration-dependent manner. CHEMBL339386 49-55 interleukin 1 beta Rattus norvegicus 152-160 25271258-4 2014 The compound blocked the ATP-induced current and Bz-ATP [2"(3")-O-(4-benzoylbenzoyl)adenosine-5"-triphosphate tri(triethylammonium)]-induced release of IL-1beta in a concentration-dependent manner. 2"(3")-o-(4-benzoylbenzoyl)adenosine-5"-triphosphate 57-109 interleukin 1 beta Rattus norvegicus 152-160 25271258-4 2014 The compound blocked the ATP-induced current and Bz-ATP [2"(3")-O-(4-benzoylbenzoyl)adenosine-5"-triphosphate tri(triethylammonium)]-induced release of IL-1beta in a concentration-dependent manner. triethylammonium) 114-131 interleukin 1 beta Rattus norvegicus 152-160 25271258-6 2014 The compound blocked the release of IL-1beta induced by Bz-ATP in freely moving rat brain. CHEMBL339386 56-62 interleukin 1 beta Rattus norvegicus 36-44 25336715-8 2014 Additionally, pro-inflammatory cytokines tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1beta, and IL-6 were upregulated by olanzapine in the hypothalamus, WAT, and BAT compared to control, but not the liver. Olanzapine 134-144 interleukin 1 beta Rattus norvegicus 81-103 23420778-7 2014 The levels of inflammatory cytokines (TNF-alpha, IL-1beta and IFN-gamma) and adhesion molecules (MCP-1, ICAM-1 and VCAM-1) increased in the gentamicin-treated kidneys. Gentamicins 140-150 interleukin 1 beta Rattus norvegicus 49-57 25446875-6 2014 The increase in TNF-alpha and IL-1beta expression induced by chronic morphine exposure was also partially blocked by PDTC pretreatment. Morphine 69-77 interleukin 1 beta Rattus norvegicus 30-38 25141943-6 2014 The animals exposed to sucrose and tobacco smoke exhibited decreased body weight, abdominal fat and plasma levels of leptin, resistin, IL-1beta and IFN-gamma, reducing inflammation but showing emphysematous lesions. Sucrose 23-30 interleukin 1 beta Rattus norvegicus 135-143 25245162-4 2014 Systemic URB597 increased IFNalpha, IFNgamma and IL-6 expression following TLR3 activation and attenuated TLR3-induced IL-1beta and TNFalpha expression. cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester 9-15 interleukin 1 beta Rattus norvegicus 119-127 25432491-13 2014 Gene expression measurements revealed that paracetamol decreased the expression of antioxidant genes and increased the expression of interleukin-1beta (IL-1beta), IL-8, tumor necrosis factor-alpha (TNF-alpha) and acute phase proteins. Acetaminophen 43-54 interleukin 1 beta Rattus norvegicus 133-150 25432491-13 2014 Gene expression measurements revealed that paracetamol decreased the expression of antioxidant genes and increased the expression of interleukin-1beta (IL-1beta), IL-8, tumor necrosis factor-alpha (TNF-alpha) and acute phase proteins. Acetaminophen 43-54 interleukin 1 beta Rattus norvegicus 152-160 25432865-4 2014 Plasma interleukin-1beta, nitric oxide and organ superoxide levels in the levosimendan-treated CLP group were less than those in CLP rats treated with vehicle (P < 0.05). Simendan 74-86 interleukin 1 beta Rattus norvegicus 7-24 25406505-10 2014 RESULTS: Silica polymorphs triggered secretion of IL-1beta, bFGF and HMGB1 in a surface reactivity dependent manner. Silicon Dioxide 9-15 interleukin 1 beta Rattus norvegicus 50-58 25403085-9 2014 CONCLUSIONS: According to our modeling of metabolic and signalization pathways using differentially expressed genes we have identified a network with major nodes (including Sirt3, Il1b, Cpt1b and Pparg) likely to underlie the observed strain specific response to ATRA. Tretinoin 263-267 interleukin 1 beta Rattus norvegicus 180-184 25035059-7 2014 Even the lowest tested doses of AP (50 mg/kg/day) or of andrographolide (30 mg/kg/day) suppressed almost maximally the blood IL-1beta and IL-10 as well as brain TNF-alpha and IL-10 expressions induced by chronic stress. andrographolide 56-71 interleukin 1 beta Rattus norvegicus 125-133 25364907-0 2014 Sertraline reduces IL-1beta and TNF-alpha mRNA expression and overcomes their rise induced by seizures in the rat hippocampus. Sertraline 0-10 interleukin 1 beta Rattus norvegicus 19-27 25364907-5 2014 For this purpose, IL-1beta and TNF-alpha mRNA expression was determined by RT-PCR in the hippocampus of rats administered once, or for seven consecutive days with sertraline at a low dose (0.75 mg/kg). Sertraline 163-173 interleukin 1 beta Rattus norvegicus 18-26 25364907-6 2014 The effect of sertraline at doses within the range of 0.75 to 25 mg/kg on the increase in IL-1beta and TNF-alpha mRNA expression accompanying generalized tonic-clonic seizures, and increase in the pro-inflammatory cytokines expression induced by lipopolysaccharide was also investigated. Sertraline 14-24 interleukin 1 beta Rattus norvegicus 90-98 25364907-7 2014 We found that under basal conditions, a single 0.75 mg/kg sertraline dose decreased IL-1beta mRNA expression, and also TNF-alpha expression after repeated doses. Sertraline 58-68 interleukin 1 beta Rattus norvegicus 84-92 25364907-8 2014 The increase in IL-1beta and TNF-alpha expression induced by the convulsive agents and by the inoculation of lipopolysaccharide in the hippocampus was markedly reduced by sertraline also. Sertraline 171-181 interleukin 1 beta Rattus norvegicus 16-24 24994592-6 2014 Chronic administration of minocycline reduced the expression of CD11b, a marker of microglial activation, and the M1 pro-inflammatory cytokine IL-1beta, in the prefrontal cortex of sham-SNL animals. Minocycline 26-37 interleukin 1 beta Rattus norvegicus 143-151 25461543-5 2014 In addition, carbaryl significantly decreased IL-2, IFN-gamma, IL-1beta and TNF-alpha and also increased IL-4, IL-10 cytokines. Carbaryl 13-21 interleukin 1 beta Rattus norvegicus 63-71 25169829-7 2014 RESULTS: Hinokitiol inhibited IL-1beta-stimulated MMP-1,-3 and -13 expressions and IL-1beta-induced activation of intracellular beta-catenin proteins in cultured chondrocytes. beta-thujaplicin 9-19 interleukin 1 beta Rattus norvegicus 30-38 25169829-7 2014 RESULTS: Hinokitiol inhibited IL-1beta-stimulated MMP-1,-3 and -13 expressions and IL-1beta-induced activation of intracellular beta-catenin proteins in cultured chondrocytes. beta-thujaplicin 9-19 interleukin 1 beta Rattus norvegicus 83-91 24955935-8 2014 IL-1beta could further increase the expression of CRH, NE, Glu, EPI, and IL-1beta and decrease GABA expression. Glutamic Acid 59-62 interleukin 1 beta Rattus norvegicus 0-8 24955935-8 2014 IL-1beta could further increase the expression of CRH, NE, Glu, EPI, and IL-1beta and decrease GABA expression. gamma-Aminobutyric Acid 95-99 interleukin 1 beta Rattus norvegicus 0-8 25108658-9 2014 Quercetin alleviated BDL-induced transforming growth factor beta-1 (TGF-beta1), interleukin-1 beta, connective tissue growth factor and collagen expression. N-(biphenyl-4-ylsulfonyl)-D-leucine 21-24 interleukin 1 beta Rattus norvegicus 80-98 25108658-9 2014 Quercetin alleviated BDL-induced transforming growth factor beta-1 (TGF-beta1), interleukin-1 beta, connective tissue growth factor and collagen expression. Quercetin 0-9 interleukin 1 beta Rattus norvegicus 80-98 25131934-7 2014 Meanwhile, high-salt-induced increases of proinflammatory factors, monocyte chemoattractant protein-1, and interleukin-1beta, in the renal medulla were blocked by MSC treatment. Salts 16-20 interleukin 1 beta Rattus norvegicus 107-124 25149586-7 2014 Propofol was associated with lower IL (interleukin)-6 and IL-1beta expression, whereas dexmedetomidine led to reduced inducible nitric oxide (iNOS) and increased nuclear factor erythroid 2-related factor 2 (Nrf2) expression in lung tissue compared to thiopental sodium. Propofol 0-8 interleukin 1 beta Rattus norvegicus 58-66 25087910-2 2014 We sought to explore whether glucosamine can activate autophagy in rat nucleus pulposus (NP) cells and protect cells treated with IL-1beta or hydrogen peroxide (H2 O2 ). Glucosamine 29-40 interleukin 1 beta Rattus norvegicus 130-138 25087910-9 2014 Autophagy in IL-1beta or H2 O2 -treated cells was increased by glucosamine. Glucosamine 63-74 interleukin 1 beta Rattus norvegicus 13-21 25087910-10 2014 Glucosamine attenuated the decrease of aggrecan and prevented the apoptosis of the NP cells induced by IL-1beta, whereas 3-MA partly reversed these effects. Glucosamine 0-11 interleukin 1 beta Rattus norvegicus 103-111 25107300-9 2014 In addition, saikosaponin a inhibited CCI-induced the levels of TNF-alpha, IL-1beta, IL-2 in spinal cord. saikosaponin D 13-27 interleukin 1 beta Rattus norvegicus 75-83 25107300-9 2014 In addition, saikosaponin a inhibited CCI-induced the levels of TNF-alpha, IL-1beta, IL-2 in spinal cord. CCI 38-41 interleukin 1 beta Rattus norvegicus 75-83 25158313-9 2014 STZ treatment caused enhanced translocation of p65 NF-kB, triggered over expression of TNF-alpha, IL-1beta, COX-2, oxidative/nitrosative stress and caspase activation (p < 0.05) in astrocytes. Streptozocin 0-3 interleukin 1 beta Rattus norvegicus 98-106 25172308-5 2014 Minocycline reverts the expression of IL-1beta and IL-6 mRNA within the spinal cord and IL-1beta mRNA in DRG, which was elevated following intrathecal administration of dynorphin (15 nmol). Minocycline 0-11 interleukin 1 beta Rattus norvegicus 38-46 25280822-6 2014 RESULTS: TNF-alpha, IL-1beta messenger RNA (mRNA) and P-IkappaB-alpha, P-IKKbeta, p53 protein expression levels were significantly increased in the saline group compared with the sham group. Sodium Chloride 148-154 interleukin 1 beta Rattus norvegicus 20-28 25175856-0 2014 Different concentrations of 17beta-estradiol modulates apoptosis induced by interleukin-1beta in rat annulus fibrosus cells. Estradiol 28-44 interleukin 1 beta Rattus norvegicus 76-93 25175856-6 2014 The present study aimed to examine whether 17beta-estradiol (17beta-E2) inhibited IL-1beta-induced apoptosis of rat annulus fibrosus (AF) cells. Estradiol 43-59 interleukin 1 beta Rattus norvegicus 82-90 25175856-6 2014 The present study aimed to examine whether 17beta-estradiol (17beta-E2) inhibited IL-1beta-induced apoptosis of rat annulus fibrosus (AF) cells. 17beta-e2 61-70 interleukin 1 beta Rattus norvegicus 82-90 25432370-7 2014 RESULTS: After 2, 6, 24 h reperfusion, compared with the IR group, the liver function (ALT, AST and LDH) in the minocycline group was significantly improved (all P<0.05); the Suzuki"s scores and the levels of hepatic TNF-alpha and IL-1beta mRNA were significantly decreased (all P<0. Minocycline 112-123 interleukin 1 beta Rattus norvegicus 234-242 25550781-7 2014 Our results demonstrated that the lung Wet/Dry weight ratio and the inflammatory mediators (TNF-alpha, IL-1beta) in BALF were decreased significantly with doxycycline treatment. Doxycycline 155-166 interleukin 1 beta Rattus norvegicus 103-111 25351234-0 2014 Toll-like receptors 2, -3 and -4 prime microglia but not astrocytes across central nervous system regions for ATP-dependent interleukin-1beta release. Adenosine Triphosphate 110-113 interleukin 1 beta Rattus norvegicus 124-141 25351234-4 2014 Here we show that purified (>99%) microglia cultured from rat cortex, spinal cord and cerebellum respond robustly to ATP-dependent IL-1beta release, upon priming with a number of TLR isoform ligands (zymosan and Pam3CSK4 for TLR2, poly(I:C) for TLR3). Adenosine Triphosphate 120-123 interleukin 1 beta Rattus norvegicus 134-142 25351234-4 2014 Here we show that purified (>99%) microglia cultured from rat cortex, spinal cord and cerebellum respond robustly to ATP-dependent IL-1beta release, upon priming with a number of TLR isoform ligands (zymosan and Pam3CSK4 for TLR2, poly(I:C) for TLR3). Zymosan 203-210 interleukin 1 beta Rattus norvegicus 134-142 25351234-7 2014 Activation of multiple TLR isoforms in nervous system pathology, coupled with elevated extracellular ATP levels and subsequent P2X7R activation may represent an important route for microglia-derived IL-1beta. Adenosine Triphosphate 101-104 interleukin 1 beta Rattus norvegicus 199-207 24975095-9 2014 TMP significantly inhibited the Abeta25-35 and IFN-gamma-stimulated productions of nitric oxide, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, monocyte chemoattractant protein-1, and intracellular reactive oxygen species from primary microglial cells. tetramethylpyrazine 0-3 interleukin 1 beta Rattus norvegicus 132-154 24975095-12 2014 Furthermore, TMP also inhibited Abeta1-42-induced TNF-alpha and IL-1beta production in primary microglial cells and neuronal death in OHSCs. tetramethylpyrazine 13-16 interleukin 1 beta Rattus norvegicus 64-72 25036265-5 2014 The results show that IL-1beta, and to a lower extent, TNF-alpha, causes cell death and that moxonidine protects against starvation- as well as IL-1beta -induced mortality, mainly by maintaining membrane integrity, and in part, by improving mitochondrial activity. moxonidine 93-103 interleukin 1 beta Rattus norvegicus 144-152 25036265-7 2014 In contrast, moxonidine stimulates basal and IL-1beta-induced fibroblast mortality by mechanisms that include inhibition of JNK and iNOS. moxonidine 13-23 interleukin 1 beta Rattus norvegicus 45-53 24975100-4 2014 Edaravone scavenged OH, NO and ONOO concentration-dependently, and borneol inhibited ischemia/reperfusion-induced tumor necrosis factor-alpha (TNF-alpha), inducible nitric oxide synthase (iNOS), interleukin-1beta (IL-1beta) and cyclooxygenase-2 (COX-2) expressions. Edaravone 0-9 interleukin 1 beta Rattus norvegicus 196-213 25064339-8 2014 The results demonstrated that doliroside A (10, 20 and 40 mg/kg) ameliorated the symptoms of gouty arthritis, decreased the levels of pro-inflammatory cytokines, and inhibited the expressions of caspase-1 and pro-interleukin-1beta (pro-IL-1beta) proteins in MSU crystals-treated rats. doliroside A 30-42 interleukin 1 beta Rattus norvegicus 236-244 25064339-10 2014 The action of doliroside A on gouty arthritis exerts via inhibiting the activation of caspase-1 and IL-1beta secretion by affecting both LPS-induced priming and inflammasome activation. doliroside A 14-26 interleukin 1 beta Rattus norvegicus 100-108 24975100-4 2014 Edaravone scavenged OH, NO and ONOO concentration-dependently, and borneol inhibited ischemia/reperfusion-induced tumor necrosis factor-alpha (TNF-alpha), inducible nitric oxide synthase (iNOS), interleukin-1beta (IL-1beta) and cyclooxygenase-2 (COX-2) expressions. Edaravone 0-9 interleukin 1 beta Rattus norvegicus 215-223 24664661-7 2014 injection of morphine (20 mug) increased the expression of IL-1beta, IL-6 and TNF-alpha mRNAs in the spinal dorsal horn. Morphine 13-21 interleukin 1 beta Rattus norvegicus 59-67 25033380-10 2014 The reduced tooth movement observed in the animals treated with 0.1mg/kg of propranolol (G3) occurred due to decreased amounts of IL-1beta and IL-6, in addition to lower ICAM-1 and RANKL expression. Propranolol 76-87 interleukin 1 beta Rattus norvegicus 130-138 24859041-9 2014 These alterations in CUMS rats were restored by chronic treatment of the antidepressant fluoxetine, indicating that fluoxetine-mediated rat PFC IL-1beta reduction involves both transcriptional and post-transcriptional regulatory mechanisms. Fluoxetine 88-98 interleukin 1 beta Rattus norvegicus 144-152 24859041-9 2014 These alterations in CUMS rats were restored by chronic treatment of the antidepressant fluoxetine, indicating that fluoxetine-mediated rat PFC IL-1beta reduction involves both transcriptional and post-transcriptional regulatory mechanisms. Fluoxetine 116-126 interleukin 1 beta Rattus norvegicus 144-152 24664661-8 2014 The co-administration of the selective AM receptor antagonist AM22-52 (36 mug) markedly attenuated chronic morphine-evoked increase in IL-1beta and IL-6, but not TNF-alpha, mRNA levels. Morphine 107-115 interleukin 1 beta Rattus norvegicus 135-143 25040499-15 2014 Furthermore, direct application of poly-I:C enhanced IL-1beta expression in primary microglia. Poly I-C 35-43 interleukin 1 beta Rattus norvegicus 53-61 24664661-9 2014 Exposure of cultured dorsal root ganglion (DRG) explants to morphine (3.3 mumol/L) for 6 days up-regulated IL-1beta and IL-6 mRNA expressions. Morphine 60-68 interleukin 1 beta Rattus norvegicus 107-115 25040499-16 2014 We therefore propose that poly-I:C-induced microglial activation, which may be at least partly caused by a direct action of poly-I:C, enhances IL-1beta expression. Poly I-C 26-34 interleukin 1 beta Rattus norvegicus 143-151 24664661-10 2014 The depletion of AM gene using small interfering RNA (siRNA) approach abolished morphine-evoked increase in IL-1beta and IL-6 syntheses in the cultured DRG. Morphine 80-88 interleukin 1 beta Rattus norvegicus 108-116 25040499-16 2014 We therefore propose that poly-I:C-induced microglial activation, which may be at least partly caused by a direct action of poly-I:C, enhances IL-1beta expression. Poly I-C 124-132 interleukin 1 beta Rattus norvegicus 143-151 24723245-13 2014 In addition, curcumin attenuated the release of TNF-alpha and IL-1beta in blood. Curcumin 13-21 interleukin 1 beta Rattus norvegicus 62-70 25041941-5 2014 Intraperitoneal injection of vinpocetine (15 mg/kg) inhibited NF-kappaB nuclear translocation and reduced the expression and activation of NLRP3, caspase-1, IL-1beta, IL-18, and TNF-alpha in the RPE of adult rats that received intraocular Alphabeta, as measured by retinal immunohistochemistry and Western blot. vinpocetine 29-40 interleukin 1 beta Rattus norvegicus 157-165 24803296-5 2014 The expression levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, IL-17 and vascular endothelial growth factor (VEGF) were obviously reduced in the sera of berberine-treated rats (all P<0.05). Berberine 180-189 interleukin 1 beta Rattus norvegicus 60-82 24748477-5 2014 Remifentanil also attenuated the concentrations of proinflammatory cytokines tumor necrosis factor alpha, interleukin-1beta, and interleukin-6 in BALF, as well as effectively repressed the activation of nuclear factor-kappaB (NF-kappaB), which has been associated with the inhibition of IkappaBalpha degradation.These results suggest that remifentanil may be a suitable treatment for LPS-induced ALI. Remifentanil 0-12 interleukin 1 beta Rattus norvegicus 106-123 25587321-0 2014 Anethole, a Medicinal Plant Compound, Decreases the Production of Pro-Inflammatory TNF-alpha and IL-1beta in a Rat Model of LPS-Induced Periodontitis. anethole 0-8 interleukin 1 beta Rattus norvegicus 97-105 24972037-13 2014 Galantamine significantly reduced IL-1beta productions when compared to the control (p<0.01). Galantamine 0-11 interleukin 1 beta Rattus norvegicus 34-42 25635252-1 2014 Interleukin-1beta (IL-1beta) has a role in beta- cell destruction in autoimmune diabetes by stimulating the expression of inducible nitric oxide synthase (iNOS) that generates the free radical nitric oxide. Nitric Oxide 132-144 interleukin 1 beta Rattus norvegicus 0-17 25635252-1 2014 Interleukin-1beta (IL-1beta) has a role in beta- cell destruction in autoimmune diabetes by stimulating the expression of inducible nitric oxide synthase (iNOS) that generates the free radical nitric oxide. Nitric Oxide 132-144 interleukin 1 beta Rattus norvegicus 19-27 25635252-13 2014 It seems that beneficial effect of Achillea millefolium L. on STZ- induced diabetes is at least partly due to amelioration of IL-1beta and iNOS gene over expression which can have a beta-cell protective effect. Streptozocin 62-65 interleukin 1 beta Rattus norvegicus 126-134 25587321-9 2014 Anethole at both concentrations significantly suppressed IL-1beta and TNF-alpha production when compared to LPS-treated rats. anethole 0-8 interleukin 1 beta Rattus norvegicus 57-65 25113124-6 2014 Melatonin decreased the augmented circulating levels of IL-1beta, IL-6, TNF-alpha, IFN-gamma, and CRP seen in obese rats and restored the depressed levels of IL-4 and IL-10. Melatonin 0-9 interleukin 1 beta Rattus norvegicus 56-64 25069417-0 2014 Dexmedetomidine suppresses interleukin-1beta-induced interleukin-6 synthesis in rat glial cells. Dexmedetomidine 0-15 interleukin 1 beta Rattus norvegicus 27-44 25069417-6 2014 In the present study, we investigated the effects of dexmedetomidine on the IL-1beta-induced IL-6 synthesis in C6 cells. Dexmedetomidine 53-68 interleukin 1 beta Rattus norvegicus 76-84 25069417-7 2014 Dexmedetomidine inhibited the IL-1beta-stimulated IL-6 release and mRNA expression in C6 cells. Dexmedetomidine 0-15 interleukin 1 beta Rattus norvegicus 30-38 25069417-8 2014 8-Bromo-adenosine-3",5"-cyclic monophosphate, but not 8-bromo-guanosine 3",5"-cyclic monophosphate, significantly enhanced the IL-1beta-induced IL-6 release and mRNA expression. 8-Bromo Cyclic Adenosine Monophosphate 0-44 interleukin 1 beta Rattus norvegicus 127-135 25069417-12 2014 Our findings strongly suggest that dexmedetomidine inhibits the IL-1beta-induced IL-6 synthesis independently of the adenylyl cyclase-cAMP pathway through alpha2-adrenoceptors in C6 glioma cells. Dexmedetomidine 35-50 interleukin 1 beta Rattus norvegicus 64-72 25187344-7 2014 Melatonin treatment also repressed cortical levels of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha), which were increased in EBI 24 hr after SAH. Melatonin 0-9 interleukin 1 beta Rattus norvegicus 82-90 25193704-2 2014 This study is the first report which demonstrates the cartilage protective effect of 5,7,3",4"-tetramethoxyflavone (TMF) by decreasing the concentration of IL-1beta, TNF-alpha and PGE2 in the knee synovial fluid in OA rat models in vivo. methoxyluteolin 85-114 interleukin 1 beta Rattus norvegicus 156-164 24859607-8 2014 The expression of TNF-alpha, IL-1beta and IL-6 in injured sites was completely inhibited by GL treatment. Glycyrrhizic Acid 92-94 interleukin 1 beta Rattus norvegicus 29-37 25256700-10 2014 Similarly, the influence of bilobalide on the expression of nitric oxide, TNF-alpha, IL-1beta, p-ERK1/2, p-JNK1/2, and p-p38 MAPK was also observed in an OGD/R in vitro model of I/R injury. bilobalide 28-38 interleukin 1 beta Rattus norvegicus 85-93 25256700-11 2014 RESULTS: Pretreatment with bilobalide (5, 10 mg/kg) significantly decreased neurological deficit scores, infarct volume, infarct weight, brain edema, and concentrations of MDA, nitric oxide, TNF-alpha, IL-1beta, and increased SOD activity. bilobalide 27-37 interleukin 1 beta Rattus norvegicus 202-210 25256700-13 2014 Supporting these observations in vivo, pretreatment with bilobalide (50, 100 muM) significantly down-regulated nitric oxide, TNF-alpha, IL-1beta, p-JNK1/2, and p-p38 MAPK expression, but did not change p-ERK1/2 expression in rat cortical neurons after OGD/R injury. bilobalide 57-67 interleukin 1 beta Rattus norvegicus 136-144 24997266-6 2014 BzATP also induced the release of the pro-inflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta, IL-6 and cytokine-induced neutrophil chemoattractant-1 (CINC-1), an effect that was significantly reduced by A-438079. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 0-5 interleukin 1 beta Rattus norvegicus 106-128 25193704-2 2014 This study is the first report which demonstrates the cartilage protective effect of 5,7,3",4"-tetramethoxyflavone (TMF) by decreasing the concentration of IL-1beta, TNF-alpha and PGE2 in the knee synovial fluid in OA rat models in vivo. methoxyluteolin 116-119 interleukin 1 beta Rattus norvegicus 156-164 24997266-7 2014 Co-administration of DALBK or bradyzide with BzATP significantly reduced BzATP-induced IL-1beta and CINC-1 release. [Leu8,des-Arg9]bradykinin 21-26 interleukin 1 beta Rattus norvegicus 87-95 25247592-8 2014 Serum levels of interleukin-1beta (IL-1beta) and IL-6 were elevated in the PTSD-like group compared with the control group, and were decreased by MPH, FLU, DES or the combination drug treatments, with the combination of DES+MPH producing the most complete rescue of the inflammatory response. Fluoxetine 151-154 interleukin 1 beta Rattus norvegicus 16-33 24997266-7 2014 Co-administration of DALBK or bradyzide with BzATP significantly reduced BzATP-induced IL-1beta and CINC-1 release. bradyzide 30-39 interleukin 1 beta Rattus norvegicus 87-95 24997266-7 2014 Co-administration of DALBK or bradyzide with BzATP significantly reduced BzATP-induced IL-1beta and CINC-1 release. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 45-50 interleukin 1 beta Rattus norvegicus 87-95 24997266-7 2014 Co-administration of DALBK or bradyzide with BzATP significantly reduced BzATP-induced IL-1beta and CINC-1 release. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 73-78 interleukin 1 beta Rattus norvegicus 87-95 25108165-4 2014 Here, we demonstrate that significant elevation of IL-1beta occurs in the cortex as early as 1h after the beginning of reperfusion in rats subjected to 2-h middle cerebral artery occlusion (MCAo). Hydrogen 93-95 interleukin 1 beta Rattus norvegicus 51-59 25247592-8 2014 Serum levels of interleukin-1beta (IL-1beta) and IL-6 were elevated in the PTSD-like group compared with the control group, and were decreased by MPH, FLU, DES or the combination drug treatments, with the combination of DES+MPH producing the most complete rescue of the inflammatory response. Fluoxetine 151-154 interleukin 1 beta Rattus norvegicus 35-43 25247592-8 2014 Serum levels of interleukin-1beta (IL-1beta) and IL-6 were elevated in the PTSD-like group compared with the control group, and were decreased by MPH, FLU, DES or the combination drug treatments, with the combination of DES+MPH producing the most complete rescue of the inflammatory response. Desipramine 156-159 interleukin 1 beta Rattus norvegicus 16-33 25247592-8 2014 Serum levels of interleukin-1beta (IL-1beta) and IL-6 were elevated in the PTSD-like group compared with the control group, and were decreased by MPH, FLU, DES or the combination drug treatments, with the combination of DES+MPH producing the most complete rescue of the inflammatory response. Desipramine 156-159 interleukin 1 beta Rattus norvegicus 35-43 25247592-8 2014 Serum levels of interleukin-1beta (IL-1beta) and IL-6 were elevated in the PTSD-like group compared with the control group, and were decreased by MPH, FLU, DES or the combination drug treatments, with the combination of DES+MPH producing the most complete rescue of the inflammatory response. Desipramine 220-223 interleukin 1 beta Rattus norvegicus 16-33 25247592-8 2014 Serum levels of interleukin-1beta (IL-1beta) and IL-6 were elevated in the PTSD-like group compared with the control group, and were decreased by MPH, FLU, DES or the combination drug treatments, with the combination of DES+MPH producing the most complete rescue of the inflammatory response. Desipramine 220-223 interleukin 1 beta Rattus norvegicus 35-43 25016361-8 2014 The results revealed that Hcy significantly induced mRNA and protein expressions of CRP in VSMCs both in vitro and in vivo, and anti-IL-1beta or anti-IL-6 neutralizing antibody alone or in combination partially reduced Hcy-induced CRP expression. Homocysteine 219-222 interleukin 1 beta Rattus norvegicus 133-141 25038313-7 2014 The levels of acute inflammatory cytokines, including interleukin-1 beta, tumor necrosis factor alpha, and interleukin-6 were attenuated by magnolol. magnolol 140-148 interleukin 1 beta Rattus norvegicus 54-101 24890001-10 2014 Physostigmine administration significantly reduced IL-1beta and AChE levels. Physostigmine 0-13 interleukin 1 beta Rattus norvegicus 51-59 24914105-7 2014 Plasma levels of IL-1beta and TNF-alpha increased significantly following radiation (P < 0.01 and P < 0.001, respectively) as compared with non-irradiated controls, and physostigmine treatment prevented the increase in the pro-inflammatory cytokines (P < 0.01 and P < 0.001, respectively). Physostigmine 175-188 interleukin 1 beta Rattus norvegicus 17-25 24903676-0 2014 The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduce inflammatory IL-1beta and TNF-alpha expression in rat hippocampus. vinpocetine 23-34 interleukin 1 beta Rattus norvegicus 97-105 24903676-0 2014 The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduce inflammatory IL-1beta and TNF-alpha expression in rat hippocampus. Carbamazepine 39-52 interleukin 1 beta Rattus norvegicus 97-105 24903676-1 2014 In the present study, the effects of the two classical anti-epileptic drugs, carbamazepine and valproic acid, and the non-classical anti-seizure drug vinpocetine were investigated on the expression of the pro-inflammatory cytokines IL-1beta and TNF-alpha in the hippocampus of rats by PCR or western blot after the administration of one or seven doses. Valproic Acid 95-108 interleukin 1 beta Rattus norvegicus 232-240 24903676-1 2014 In the present study, the effects of the two classical anti-epileptic drugs, carbamazepine and valproic acid, and the non-classical anti-seizure drug vinpocetine were investigated on the expression of the pro-inflammatory cytokines IL-1beta and TNF-alpha in the hippocampus of rats by PCR or western blot after the administration of one or seven doses. vinpocetine 150-161 interleukin 1 beta Rattus norvegicus 232-240 24903676-5 2014 Results show that vinpocetine and carbamazepine reduced the expression of IL-1beta and TNF-alpha from basal conditions, and the increase in both pro-inflammatory cytokines induced by LPS. vinpocetine 18-29 interleukin 1 beta Rattus norvegicus 74-82 24903676-5 2014 Results show that vinpocetine and carbamazepine reduced the expression of IL-1beta and TNF-alpha from basal conditions, and the increase in both pro-inflammatory cytokines induced by LPS. Carbamazepine 34-47 interleukin 1 beta Rattus norvegicus 74-82 24903676-7 2014 Tonic-clonic seizures induced either by 4-aminopyridine, pentylenetetrazole or pilocarpine increased the expression of IL-1beta and TNF-alpha markedly. 4-Aminopyridine 40-55 interleukin 1 beta Rattus norvegicus 119-127 24903676-7 2014 Tonic-clonic seizures induced either by 4-aminopyridine, pentylenetetrazole or pilocarpine increased the expression of IL-1beta and TNF-alpha markedly. Pentylenetetrazole 57-75 interleukin 1 beta Rattus norvegicus 119-127 24903676-7 2014 Tonic-clonic seizures induced either by 4-aminopyridine, pentylenetetrazole or pilocarpine increased the expression of IL-1beta and TNF-alpha markedly. Pilocarpine 79-90 interleukin 1 beta Rattus norvegicus 119-127 24893328-12 2014 The effect of parthenolide and the outcomes obtained so far suggest that HMGB1 indirectly up-regulates AQP4 expression through diffusible factor(s) such as IL-1beta from microglia since HMGB1 by itself didnot affect NF-kappaB intracellular localization in astrocytes. parthenolide 14-26 interleukin 1 beta Rattus norvegicus 156-164 25318094-5 2014 RESULTS: Compared with controls, reduced levels of the kinin B2 receptors IL1beta and TNFalpha were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin. Indomethacin 195-207 interleukin 1 beta Rattus norvegicus 74-81 24985046-0 2014 Ceftriaxone pretreatment protects rats against cerebral ischemic injury by attenuating microglial activation-induced IL-1beta expression. Ceftriaxone 0-11 interleukin 1 beta Rattus norvegicus 117-125 24878007-8 2014 Erythromycin may up-regulate the activity of gamma-GCS, increasing the expression of GSH, inhibiting the levels of oxidant-mediated IL-1 beta and alleviating hyperoxia-induced lung injury via an antioxidant effect. Erythromycin 0-12 interleukin 1 beta Rattus norvegicus 132-141 24571083-7 2014 Similarly, IFN-gamma and IL-1beta protein levels were significantly increased in ZDF rats compared to ZLC rats at 30 weeks of age, but not at 12 and 20 weeks of age. zdf 81-84 interleukin 1 beta Rattus norvegicus 25-33 24571083-7 2014 Similarly, IFN-gamma and IL-1beta protein levels were significantly increased in ZDF rats compared to ZLC rats at 30 weeks of age, but not at 12 and 20 weeks of age. zlc 102-105 interleukin 1 beta Rattus norvegicus 25-33 24571083-8 2014 Interleukin-1beta immunoreactivity in the ZDF rats predominantly increased in the dentate gyrus and CA1 region of the hippocampus compared to that of ZLC rats at 30 weeks of age. zdf 42-45 interleukin 1 beta Rattus norvegicus 0-17 24571083-9 2014 In addition, IL-1beta immunoreactive structures in ZDF rats at 30 weeks of age were detected near the astrocytes and microglia. zdf 51-54 interleukin 1 beta Rattus norvegicus 13-21 24914105-9 2014 In the liver and ileum homogenates, IL-1beta and TNF-alpha levels were also elevated following radiation, and this effect was inhibited by physostigmine treatment but not by atropine. Physostigmine 139-152 interleukin 1 beta Rattus norvegicus 36-44 24651933-0 2014 Curcumin attenuates ischemia-like injury induced IL-1beta elevation in brain microvascular endothelial cells via inhibiting MAPK pathways and nuclear factor-kappaB activation. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 49-57 24651933-6 2014 The treatment of curcumin (20 muM) inhibited the increased production of IL-1beta both at the protein and mRNA levels. Curcumin 17-25 interleukin 1 beta Rattus norvegicus 73-81 24651933-7 2014 The increased phosphorylation of p38 and JNK induced by OGD was decreased under the treatment of curcumin, whereas the p38 inhibitor, SB203580, significantly inhibited OGD-induced IL-1beta production, but the JNK inhibitor, SP600125, failed to do so. Curcumin 97-105 interleukin 1 beta Rattus norvegicus 180-188 25064822-7 2014 KEY FINDINGS: Sodium nitrite resulted in increased TNF-alpha (1.6-fold), IL-1beta (3.7-fold) and CRP (2.4-fold) levels accompanied by 52%, 59% and 40% reductions in IL-10, IL-4 and cytochrome-C-oxidase, respectively, as well as enhanced JNK, caspase-3, caspase-8 and caspase-9 activities. Sodium Nitrite 14-28 interleukin 1 beta Rattus norvegicus 73-81 24651933-7 2014 The increased phosphorylation of p38 and JNK induced by OGD was decreased under the treatment of curcumin, whereas the p38 inhibitor, SB203580, significantly inhibited OGD-induced IL-1beta production, but the JNK inhibitor, SP600125, failed to do so. SB 203580 134-142 interleukin 1 beta Rattus norvegicus 180-188 24651933-8 2014 These results suggest that the inhibition of IL-1beta by curcumin may dependent on the p38 signaling pathway. Curcumin 57-65 interleukin 1 beta Rattus norvegicus 45-53 24871567-8 2014 Administration of hesperetin resulted in a dose dependent attenuation in PSNL-induced mechanical and thermal hyperalgesia, mechanical allodynia as well as down regulation of IL-1beta, IL-6 and TNF-alpha, and biochemical markers. hesperetin 18-28 interleukin 1 beta Rattus norvegicus 174-182 25101546-6 2014 Chronic treatment with SA could remarkably reduce TNF-alpha and IL-1beta levels in hippocampus. rhodioloside 23-25 interleukin 1 beta Rattus norvegicus 64-72 28962276-3 2014 Administration of bromobenzene (10 mmol/kg body weight) to rats resulted in increased levels of liver marker enzymes, lipid peroxidation, TNF-alpha, IL-1beta and VEGF. bromobenzene 18-30 interleukin 1 beta Rattus norvegicus 149-157 24933538-6 2014 Rosiglitazone completely prevented the increase in the levels of IL-1beta and IFNgamma induced by Abeta42 oligomers. Rosiglitazone 0-13 interleukin 1 beta Rattus norvegicus 65-73 25153082-6 2014 The major changes found in paraquat-treated animals were: decreased body weight and hypothermia, nociception behavior, impairment of locomotor and gait capabilities, enhanced TNF-alpha and IL-1beta expression in the striatum, and cell migration to the lungs and blood. Paraquat 27-35 interleukin 1 beta Rattus norvegicus 189-197 25153082-7 2014 Some of these parameters were reversed when the antagonist SB225002 was administered, including recovery of physiological parameters, decreased nociception, improvement of gait abnormalities, modulation of striatal TNF-alpha and IL-1beta expression, and decrease of neutrophil migration to the lungs and blood. SB 225002 59-67 interleukin 1 beta Rattus norvegicus 229-237 24960633-4 2014 DPN pre-treatment decreased the expression levels of pro-inflammatory cytokines IL-1beta and IL-6 through attenuation of Abeta1-42-induced phosphorylation of mitogen-activated protein kinases JNK and p38. diarylpropionitrile 0-3 interleukin 1 beta Rattus norvegicus 80-88 24862493-10 2014 The overproduction of TNF-alpha and IL-1beta were remarkably suppressed in the serum of all EXS-treated rats, and in contrast IL-10 was markedly increased. (2R)-2,4-dihydroxy-N-[2-(7-hydroxy-1H-benzimidazol-2-yl)ethyl]-3,3-dimethylbutanamide 92-95 interleukin 1 beta Rattus norvegicus 36-44 24949817-0 2014 Andrographolide attenuates interleukin-1beta-stimulated upregulation of chemokine CCL5 and glial fibrillary acidic protein in astrocytes. andrographolide 0-15 interleukin 1 beta Rattus norvegicus 27-44 24949817-5 2014 Andrographolide pretreatment was found to attenuate the upregulation of CCL5 and glial fibrillary basic protein as well as reduce the phosphorylation of nuclear factor-kappaB p65 and IkappaBalpha after interleukin 1beta stimulation. andrographolide 0-15 interleukin 1 beta Rattus norvegicus 202-219 25136835-14 2014 ROS inhibition markedly decreased nuclear factor-kB (NF-kB) phosphorylation, thioredoxin interacting/inhibiting protein (TXNIP), NLRP3 inflammasome, and mature IL-1beta in high glucose treated H9c2 cells. ros 0-3 interleukin 1 beta Rattus norvegicus 160-168 25136835-14 2014 ROS inhibition markedly decreased nuclear factor-kB (NF-kB) phosphorylation, thioredoxin interacting/inhibiting protein (TXNIP), NLRP3 inflammasome, and mature IL-1beta in high glucose treated H9c2 cells. Glucose 177-184 interleukin 1 beta Rattus norvegicus 160-168 25136835-18 2014 NF-kappaB and TXNIP mediated the ROS-induced caspase-1 and IL-1beta activation, which are the effectors of NLRP3 inflammasome. ros 33-36 interleukin 1 beta Rattus norvegicus 59-67 24797782-5 2014 KHG26693 also suppressed several inflammatory responses in STZ-induced diabetic rats, as evidenced by decreased levels of serum tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide. N-adamantyl-4-methylthiazol-2-amine 0-8 interleukin 1 beta Rattus norvegicus 157-174 24797782-5 2014 KHG26693 also suppressed several inflammatory responses in STZ-induced diabetic rats, as evidenced by decreased levels of serum tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide. Streptozocin 59-62 interleukin 1 beta Rattus norvegicus 157-174 24877639-9 2014 Ellagic acid also significantly reduced the serum levels of pro-inflammatory cytokines, interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha). Ellagic Acid 0-12 interleukin 1 beta Rattus norvegicus 88-105 24880026-9 2014 Naringin treatment at 40 and 80 mg/kg resulted in significant (P<0.05) up-regulation of mRNA expression of growth factor (IFG-1, TGF-beta and VEGF-c), Ang-1 and collagen-1 whereas mRNA expression of inflammatory mediators (TNF-alpha, IL-1beta and IL-6) was down-regulated. naringin 0-8 interleukin 1 beta Rattus norvegicus 237-245 24877639-9 2014 Ellagic acid also significantly reduced the serum levels of pro-inflammatory cytokines, interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha). Ellagic Acid 0-12 interleukin 1 beta Rattus norvegicus 107-115 24496569-6 2014 The protein and mRNA expression levels of IL-1beta, IL-6, TNF-alpha, and IFN-gamma were significantly higher in the DM group than in the NC group (p < 0.05), whereas in the resveratrol-treated groups (NB and DB), the levels were relatively lower than those in the corresponding groups. Resveratrol 176-187 interleukin 1 beta Rattus norvegicus 42-50 24937348-10 2014 Furthermore, we found that the beneficial effects of hydrogen-rich saline treatment were associated with decreased levels of oxidative products (8-iso-prostaglandin F2alpha and malondialdehyde) and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and high-mobility group box protein 1), as well as the increased activity of antioxidant enzymes (superoxide dismutase and catalase) in serum and brain tissues. Hydrogen 53-61 interleukin 1 beta Rattus norvegicus 251-268 24937348-10 2014 Furthermore, we found that the beneficial effects of hydrogen-rich saline treatment were associated with decreased levels of oxidative products (8-iso-prostaglandin F2alpha and malondialdehyde) and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and high-mobility group box protein 1), as well as the increased activity of antioxidant enzymes (superoxide dismutase and catalase) in serum and brain tissues. Sodium Chloride 67-73 interleukin 1 beta Rattus norvegicus 251-268 25132762-13 2014 Serum IL-1beta levels in the SAP-S group were 276.77 +- 44.92 pg/mL at 6 h, 308.99 +- 34.95 pg/mL at 12 h, and 311.60 +- 46.51 pg/mL at 18 h; all significantly higher than those in the HC and SAP-ICE-I groups (P < 0.01 for all). sap-s 29-34 interleukin 1 beta Rattus norvegicus 6-14 24496569-7 2014 The DM group showed reduced levels of DNA methylation at the specific cytosine phosphate guanosine sites of IL-1beta, IL-6, TNF-alpha, and IFN-gamma, relative to those in the NC group (p < 0.01), and these levels were increased by resveratrol. cytosine phosphate guanosine 70-98 interleukin 1 beta Rattus norvegicus 108-116 24496569-7 2014 The DM group showed reduced levels of DNA methylation at the specific cytosine phosphate guanosine sites of IL-1beta, IL-6, TNF-alpha, and IFN-gamma, relative to those in the NC group (p < 0.01), and these levels were increased by resveratrol. Resveratrol 234-245 interleukin 1 beta Rattus norvegicus 108-116 25434084-1 2014 OBJECTIVE: To explore the effect of nitric oxide (NO) on the gene expression of hepatic TNF-alpha and IL-1beta by crush injury of rat"s soft tissues. Nitric Oxide 36-48 interleukin 1 beta Rattus norvegicus 102-110 24928403-4 2014 Pretreatment with stansin 6 inhibited convulsions in rats from kainic acid-induced seizures, reduced the degeneration pattern in the CA3 region, decreased astrocytic reactivity, and reduced the expression of IL-1beta and TNF-alpha induced by kainic acid. stansin 6 18-27 interleukin 1 beta Rattus norvegicus 208-216 25434084-6 2014 After pretreated L-Arg, expressions of TNF-alpha and IL-1beta mRNA were markedly increased (P<0.05). Arginine 17-22 interleukin 1 beta Rattus norvegicus 53-61 24618002-11 2014 Importantly, sophocarpine (20 and 40 mg/kg) decreased pro-inflammatory cytokine levels (IL-6, 14.6% and 18.5%; IL-1beta, 23.1% and 32.6%), collagen content (27.7% and 50.1%), as well as matrix metalloproteinases-2, 9 (MMP-2, 9) expression (MMP-2, 11.8% and 18.5%; MMP-9, 16.2% and 21.1%). sophocarpine 13-25 interleukin 1 beta Rattus norvegicus 111-119 24626059-1 2014 The recreational drug 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") produces a neuro-inflammatory response in rats characterized by an increase in microglial activation and IL-1beta levels. N-Methyl-3,4-methylenedioxyamphetamine 22-55 interleukin 1 beta Rattus norvegicus 179-187 24626059-1 2014 The recreational drug 3,4-methylenedioxymethamphetamine (MDMA; "ecstasy") produces a neuro-inflammatory response in rats characterized by an increase in microglial activation and IL-1beta levels. N-Methyl-3,4-methylenedioxyamphetamine 57-61 interleukin 1 beta Rattus norvegicus 179-187 25068701-2 2014 In the present study, using the INS-1 rat pancreatic beta-cell line, we investigated the potential involvement of membrane-associated cholesterol-enriched lipid rafts in IL-1beta signaling and biological effects on insulin secretion, beta-cell proliferation and apoptosis. Cholesterol 134-145 interleukin 1 beta Rattus norvegicus 170-178 25322555-1 2014 The effect of amygdalin joint hydroxysafflor yellow A (HSYA) on the endplate chondrocytes derived from intervertebral discs of rats induced by IL-1beta and the possible mechanism were studied and explored. amygdalin joint hydroxysafflor yellow a 14-53 interleukin 1 beta Rattus norvegicus 143-151 25322555-1 2014 The effect of amygdalin joint hydroxysafflor yellow A (HSYA) on the endplate chondrocytes derived from intervertebral discs of rats induced by IL-1beta and the possible mechanism were studied and explored. hydroxysafflor yellow A 55-59 interleukin 1 beta Rattus norvegicus 143-151 24768528-12 2014 CcL also reduced the leukocyte influx and the expression of IL-1beta and TNF-alpha in the TMJ, based on histopathological and immunohistochemistry analyses, respectively. Cefaclor 0-3 interleukin 1 beta Rattus norvegicus 60-68 24858057-6 2014 We found that rotenone (1 and 3 nM) increased BV2 microglial phagocytosis and the release of the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha). Rotenone 14-22 interleukin 1 beta Rattus norvegicus 124-141 24858057-6 2014 We found that rotenone (1 and 3 nM) increased BV2 microglial phagocytosis and the release of the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha). Rotenone 14-22 interleukin 1 beta Rattus norvegicus 143-151 24858057-10 2014 Rotenone also increased CysLT(1)R expression and induced nuclear translocation of CysLT(1)R. In primary rat microglia, rotenone (10 nM) increased release of IL-1beta and TNF-alpha, whereas zileuton (0.1 muMu) and montelukast (0.01 muMu) significantly inhibited this response. Rotenone 0-8 interleukin 1 beta Rattus norvegicus 157-165 24858057-10 2014 Rotenone also increased CysLT(1)R expression and induced nuclear translocation of CysLT(1)R. In primary rat microglia, rotenone (10 nM) increased release of IL-1beta and TNF-alpha, whereas zileuton (0.1 muMu) and montelukast (0.01 muMu) significantly inhibited this response. Rotenone 119-127 interleukin 1 beta Rattus norvegicus 157-165 25509306-9 2014 Polydatin downregulated I/R induced mRNA and protein expressions of TLR4, and decreased the protein expression of NF-kappaB, TNF-alpha and IL-1beta. polydatin 0-9 interleukin 1 beta Rattus norvegicus 139-147 24951883-10 2014 We also discovered that hydrogen-rich saline not 2.5 ml/kg but 5 and 10 ml/kg could dose-dependently attenuate mechanical and thermal hyperalgesia without affecting baseline nociceptive threshold, reduce expressions of inflammatory mediators (TNF-alpha, IL-1beta, and IL-6) and decrease NR1 trafficking mediated by GSK-3beta, and minimal effective concentration was observed to be higher than 10 mumol/L, namely peak concentration in arterial blood after administration of HRS 2.5 ml/kg without any influence on hyperalgesia. Hydrogen 24-32 interleukin 1 beta Rattus norvegicus 254-262 24951883-10 2014 We also discovered that hydrogen-rich saline not 2.5 ml/kg but 5 and 10 ml/kg could dose-dependently attenuate mechanical and thermal hyperalgesia without affecting baseline nociceptive threshold, reduce expressions of inflammatory mediators (TNF-alpha, IL-1beta, and IL-6) and decrease NR1 trafficking mediated by GSK-3beta, and minimal effective concentration was observed to be higher than 10 mumol/L, namely peak concentration in arterial blood after administration of HRS 2.5 ml/kg without any influence on hyperalgesia. Sodium Chloride 38-44 interleukin 1 beta Rattus norvegicus 254-262 24738479-7 2014 Furthermore, early treatment with ALA markedly inhibited the release of tumour necrosis factor-alpha, interleukin (IL)-6 and IL-1beta into the serum and reduced mRNA and protein expression of inducible nitric oxide synthase and high mobility group box 1 in kidney tissues from CLP-induced rats. Thioctic Acid 34-37 interleukin 1 beta Rattus norvegicus 125-133 24768528-13 2014 Therefore, CcL reduces TMJ hyper-nociception and inflammation with a mechanism that is partially dependent on TNF-alpha and IL-1beta inhibition. Cefaclor 11-14 interleukin 1 beta Rattus norvegicus 124-132 24768584-2 2014 In this study, we investigated the effect of CTXA on IL-1beta (5 ng/ml) and IFN-gamma (100 U/ml)-induced beta-cell damage. cudratricusxanthone A 45-49 interleukin 1 beta Rattus norvegicus 53-61 24825147-10 2014 RESULTS: Experiment 1: IVD levels of tumor necrosis factor-alpha (through 2 wk), IL-1beta (at 4 d), and IL-6 (at 4 d) were significantly higher in the saline group than in the sham group, and significantly lower in the IKKbeta group than in the saline group (P < 0.05). Sodium Chloride 151-157 interleukin 1 beta Rattus norvegicus 81-89 24857811-4 2014 In this context, this study investigated the long-lasting effects of lovastatin on mRNA expression of proinflammatory cytokines (interleukin-1beta, tumor necrosis factor alpha, interleukin-6) and the antiinflammatory cytokine IL-10 in the hippocampus during epileptogenesis by immunohistochemistry and real time polymerase chain reaction (RT-PCR) during the latent and chronic phases in the epilepsy model induced by pilocarpine in rats. Lovastatin 69-79 interleukin 1 beta Rattus norvegicus 129-175 24857811-9 2014 The pilocarpine plus lovastatin group showed a significant decrease in the levels of IL-1beta, TNF-alpha, and IL-6 during the latent phase and a decreased expression of IL-1beta and TNF-alpha in the chronic phase when compared with the PILO group. Pilocarpine 4-15 interleukin 1 beta Rattus norvegicus 85-93 24687774-5 2014 The mechanistic studies showed that mulberroside A decreased the expressions of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 and inhibited the activation of NALP3, caspase-1, and nuclear factor-kappaB and the phosphorylation of extracellular signal-regulated protein kinases, the c-Jun N-terminal kinase, and p38, exhibiting anti-inflammatory antiapoptotic effects. mulberroside A 36-50 interleukin 1 beta Rattus norvegicus 121-143 24746834-6 2014 We showed that, after 1-, 2- or 5-day exposure of rats to 16 Hz, 130 dB infrasound (2 h/day), EGCG significantly inhibited infrasound-induced microglial activation in rat hippocampal region, evidenced by reduced expressions of Iba-1 (a marker for microglia) and proinflammatory cytokines (IL-1beta, IL-6, IL-18 and TNF-alpha). epigallocatechin gallate 94-98 interleukin 1 beta Rattus norvegicus 289-297 24037056-9 2014 T-2 toxin under a selenium-deficient nutritional status induces increased levels of IL-6, IL-1beta, and TNF-alpha in serum and cartilages, which may account for the pathological mechanism underlying the cartilage damage in KBD. Selenium 18-26 interleukin 1 beta Rattus norvegicus 90-98 24857811-9 2014 The pilocarpine plus lovastatin group showed a significant decrease in the levels of IL-1beta, TNF-alpha, and IL-6 during the latent phase and a decreased expression of IL-1beta and TNF-alpha in the chronic phase when compared with the PILO group. Pilocarpine 4-15 interleukin 1 beta Rattus norvegicus 169-177 24857811-9 2014 The pilocarpine plus lovastatin group showed a significant decrease in the levels of IL-1beta, TNF-alpha, and IL-6 during the latent phase and a decreased expression of IL-1beta and TNF-alpha in the chronic phase when compared with the PILO group. Lovastatin 21-31 interleukin 1 beta Rattus norvegicus 85-93 24857811-9 2014 The pilocarpine plus lovastatin group showed a significant decrease in the levels of IL-1beta, TNF-alpha, and IL-6 during the latent phase and a decreased expression of IL-1beta and TNF-alpha in the chronic phase when compared with the PILO group. Lovastatin 21-31 interleukin 1 beta Rattus norvegicus 169-177 24722948-5 2014 In streptozotocin-induced diabetic rats, hyperglycemia induced glomerular hypertrophy and fibrosis in association with increased IL-1beta, fibronectin, and CB1R expressions and reduced PPARgamma2 signaling. Streptozocin 3-17 interleukin 1 beta Rattus norvegicus 129-137 24774438-8 2014 RESULTS: The pretreatment with GW0742 significantly increased the expression of Bcl-2, and significantly decreased in the volume of infarction, NDS, edema, expressions of IL-1beta, NF-kappaB, TNFalpha, and Bax, contents of iNOS and the apoptotic cells in infarct cerebral hemisphere compared with rats in the vehicle group at 24 hours after MCAO. GW0742 31-37 interleukin 1 beta Rattus norvegicus 171-179 24338136-7 2014 The binding of Iba-1 and IL-1beta antibody was significantly lower in the BoNT-A group than the saline group at 1 and 2 weeks after BoNT-A injection. Sodium Chloride 96-102 interleukin 1 beta Rattus norvegicus 25-33 24338136-8 2014 The number of Iba-1 and IL-1beta-IR cells at 1 and 2 weeks after the injection of BoNT-A were significantly different from the corresponding number of Iba-1 and IL-1beta-IR cells in the saline group. Sodium Chloride 186-192 interleukin 1 beta Rattus norvegicus 161-169 25671080-11 2014 We identified several genes (IL-1beta, IL-6, iNOS, TGF-beta, and NGF) whose transcription was elevated 24 h after the study intervention, and whose expression levels significantly differed between argon treatment and placebo following tMCAO. Argon 197-202 interleukin 1 beta Rattus norvegicus 29-37 25182814-8 2014 CONCLUSION: Acrylonitrile may lead to the changes of CD3, CD4, CD8 T lymphocyte percentages and CD4/CD8 ratio in rat blood and spleen, and also significantly effected the expression level of TLR4 mRNA and protein together with the secretion of IL-1beta, TNF-alpha. Acrylonitrile 12-25 interleukin 1 beta Rattus norvegicus 244-252 24810974-8 2014 When malathion-treated rats were compared to NAC supplemented rats, leukocytosis, T cell count and IL-1beta, IL-6, INF-gamma expression were reduced. Malathion 5-14 interleukin 1 beta Rattus norvegicus 99-107 24810974-8 2014 When malathion-treated rats were compared to NAC supplemented rats, leukocytosis, T cell count and IL-1beta, IL-6, INF-gamma expression were reduced. Acetylcysteine 45-48 interleukin 1 beta Rattus norvegicus 99-107 24425537-12 2014 Treatment with LMWH significantly decreased the expression of TNF-alpha, IL-1beta, HMGB1 and ICAM-1 in the lung of ALI rats. Heparin, Low-Molecular-Weight 15-19 interleukin 1 beta Rattus norvegicus 73-81 25120739-0 2014 Interleukin-1beta induces autophagy by affecting calcium homeostasis and trypsinogen activation in pancreatic acinar cells. Calcium 49-56 interleukin 1 beta Rattus norvegicus 0-17 24750893-7 2014 RESULTS: Seizures induced by intra-amygdala kainic acid increased levels of P2X7 receptor protein and interleukin-1beta and caused significant cell death within the ipsilateral hippocampus. Kainic Acid 44-55 interleukin 1 beta Rattus norvegicus 102-119 24492951-0 2014 Swertiamarin ameliorates inflammation and osteoclastogenesis intermediates in IL-1beta induced rat fibroblast-like synoviocytes. swertiamarin 0-12 interleukin 1 beta Rattus norvegicus 78-86 24492951-3 2014 In the present study, the potential of swertiamarin was evaluated in IL-1beta induced fibroblast-like synoviocytes (FLS). swertiamarin 39-51 interleukin 1 beta Rattus norvegicus 69-77 24492951-11 2014 CONCLUSION: These findings suggest that treatment with swertiamarin attenuated IL-1beta induced FLS, and it revealed anti-inflammatory potential by attenuating aggressive FLS. swertiamarin 55-67 interleukin 1 beta Rattus norvegicus 79-87 24469603-0 2014 Astragaloside IV possesses antiarthritic effect by preventing interleukin 1beta-induced joint inflammation and cartilage damage. astragaloside A 0-16 interleukin 1 beta Rattus norvegicus 62-79 24675438-5 2014 Curcumin application increased the wound contraction and decreased the expressions of inflammatory cytokines/enzymes i.e. tumor necrosis factor-alpha, interleukin (IL)-1beta and matrix metalloproteinase-9. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 151-173 24535716-9 2014 Administration of diosgenin before the main ischemia significantly reduced the levels of IL-6 (P < 0.05), IL-1beta, and TNF-alpha (P < 0.01) in the reperfusion phase of diosgenin-treated hearts as compared with untreated control hearts. Diosgenin 18-27 interleukin 1 beta Rattus norvegicus 109-117 24676878-7 2014 Results showed significant lower expression of IL-1beta, IL-6, TGF-beta, TNF-alpha, and ICAM-1, in berberine groups compared with the operation group. Berberine 99-108 interleukin 1 beta Rattus norvegicus 47-55 24482305-5 2014 In EAN sciatic nerves, curcumin treatment suppressed the inflammatory cell accumulation and the expression of interferon (IFN)-gamma, tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-17. Curcumin 23-31 interleukin 1 beta Rattus norvegicus 163-185 24662629-12 2014 TNF-alpha, IL-1beta TNFR1A, and COX-2 mRNA levels were upregulated by gentamicin (p < 0.05). Gentamicins 70-80 interleukin 1 beta Rattus norvegicus 11-19 25244766-3 2014 Quercetin with the concentrations of 82.78, 41.39, 20.70 micromol x L(-1) could notably inhibit the increase of TNF-alpha and IL-1beta induced by LPS 100 microg x L(-1) for 3 h and then ATP 5 mmol x L(-1) for 36 h (P < 0.01 or P < 0.05). Quercetin 0-9 interleukin 1 beta Rattus norvegicus 126-134 25244766-3 2014 Quercetin with the concentrations of 82.78, 41.39, 20.70 micromol x L(-1) could notably inhibit the increase of TNF-alpha and IL-1beta induced by LPS 100 microg x L(-1) for 3 h and then ATP 5 mmol x L(-1) for 36 h (P < 0.01 or P < 0.05). Adenosine Triphosphate 186-189 interleukin 1 beta Rattus norvegicus 126-134 25244766-8 2014 Therefore, this study believes that quercetin could attenuate the secretion of inflammatory factors TNF-alpha, IL-1beta and IL-6 of cardiac fibroblasts by inhibiting the activation of NF-kappaB p65 (S276) and Akt (473). Quercetin 36-45 interleukin 1 beta Rattus norvegicus 111-119 24630969-8 2014 At the same time, tea polyphenol pretreatment attenuated the increased level of serum IL-1beta, IL-6, ICAM-1 and TNF-alpha, and enhanced IL-10 production in RIRI rats. Polyphenols 22-32 interleukin 1 beta Rattus norvegicus 86-94 25174378-20 2014 Activation of SIRT1 by RSV can alleviate myocardial tissue injury and reduce apoptosis of cardiac myocytes and secretion of IL-1beta and TNF-alpha. Resveratrol 23-26 interleukin 1 beta Rattus norvegicus 124-132 24857932-9 2014 We also showed that the analgesic effect of hydrogen-rich normal saline was associated with decreased activation of astrocytes and microglia, attenuated expression of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the spinal cord. hydrogen-rich normal saline 44-71 interleukin 1 beta Rattus norvegicus 167-184 24857932-9 2014 We also showed that the analgesic effect of hydrogen-rich normal saline was associated with decreased activation of astrocytes and microglia, attenuated expression of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the spinal cord. hydrogen-rich normal saline 44-71 interleukin 1 beta Rattus norvegicus 186-194 24884762-15 2014 The incubation of control hippocampal slices with IL-1beta and IL-6 abolished tetraethylammonium-induced GluR1 trafficking and phosphorylation. Tetraethylammonium 78-96 interleukin 1 beta Rattus norvegicus 50-58 24642361-0 2014 The role of interleukin-1beta in the pentylenetetrazole-induced kindling of seizures, in the rat hippocampus. Pentylenetetrazole 37-55 interleukin 1 beta Rattus norvegicus 12-29 24747612-9 2014 It also decreased the synthesis of cytokine IL-1beta and TNF-alpha in substantia nigra and recovered the motor dysfunction in the rats injected with MPTP. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 149-153 interleukin 1 beta Rattus norvegicus 44-52 24884664-11 2014 mannose pretreatment significantly and dose-dependently prolonged pDNA-IL-10 pain suppressive effects, reduced spinal IL-1beta and enhanced spinal and dorsal root ganglia IL-10 immunoreactivity. Mannose 0-7 interleukin 1 beta Rattus norvegicus 118-126 24884664-12 2014 Macrophages exposed to D-mannose revealed reduced proinflammatory TNF-alpha, IL-1beta, and nitric oxide, and increased IL-10 protein release, while IL-4 revealed no improvement in transgene uptake. Mannose 23-32 interleukin 1 beta Rattus norvegicus 77-85 24884548-10 2014 RESULTS: In gp120ADA-injected rats, mRNA transcripts of interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) were significantly elevated in the frontal cortex, striatum and hippocampus compared to saline or heat-inactivated gp120-injected controls. Sodium Chloride 216-222 interleukin 1 beta Rattus norvegicus 56-73 24884548-10 2014 RESULTS: In gp120ADA-injected rats, mRNA transcripts of interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) were significantly elevated in the frontal cortex, striatum and hippocampus compared to saline or heat-inactivated gp120-injected controls. Sodium Chloride 216-222 interleukin 1 beta Rattus norvegicus 75-83 24680620-5 2014 The remarkable decrement of serum inflammatory factors (TNF-alpha, IL-1beta and IL-6) were observed in EVNS-treated rats, whereas, IL-10, an anti-inflammatory cytokine, was found to be significantly increased by EVNS. evns 103-107 interleukin 1 beta Rattus norvegicus 67-75 24636743-0 2014 Uncaria rhynchophylla and rhynchophylline improved kainic acid-induced epileptic seizures via IL-1beta and brain-derived neurotrophic factor. rhyncophylline 26-41 interleukin 1 beta Rattus norvegicus 94-102 24636743-0 2014 Uncaria rhynchophylla and rhynchophylline improved kainic acid-induced epileptic seizures via IL-1beta and brain-derived neurotrophic factor. Kainic Acid 51-62 interleukin 1 beta Rattus norvegicus 94-102 24669856-8 2014 Inflammatory proteins (COX2, iNOS, and nNOS) and proinflammatory cytokines (TNF-alpha and IL-1beta) induced by CCI were decreased in the KMUP-1 treated group at day 7 after surgery. CCI 111-114 interleukin 1 beta Rattus norvegicus 90-98 24886466-8 2014 Prenatal dexamethasone also programmed increased adipose expression of Il6, Il1b (both P < 0.05) and Tnfa (P < 0.001) mRNAs regardless of fetal sex, but again this effect was prevented (for Il6 and Il1b) by Hn3 consumption. Dexamethasone 9-22 interleukin 1 beta Rattus norvegicus 76-80 24886466-8 2014 Prenatal dexamethasone also programmed increased adipose expression of Il6, Il1b (both P < 0.05) and Tnfa (P < 0.001) mRNAs regardless of fetal sex, but again this effect was prevented (for Il6 and Il1b) by Hn3 consumption. Dexamethasone 9-22 interleukin 1 beta Rattus norvegicus 204-208 24488033-7 2014 This neurotoxicity was antagonized by minocycline and the observed neuroprotective effects were associated with the ability of minocycline to suppress the expression of tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide synthase. Minocycline 127-138 interleukin 1 beta Rattus norvegicus 198-215 24481487-6 2014 The two-way ANOVA of pro-inflammatory cytokine levels demonstrated a significant exercise x caffeine interaction for IL-1beta (F (1, 16) = 9.5772; p = 0.0069), IL-6 (F (1, 16) = 8.0463; p = 0.0119) and INF-gamma (F (1, 16) = 15.078; p = 0.0013). Caffeine 92-100 interleukin 1 beta Rattus norvegicus 117-125 24468888-11 2014 In addition, induction of ER stress by tunicamycin resulted in significantly increased expression of pro-inflammatory molecules such as IL-1beta and TNF-alpha in cultured inflammatory FLS. Tunicamycin 39-50 interleukin 1 beta Rattus norvegicus 136-144 24648308-0 2014 beta-Ecdysterone suppresses interleukin-1beta-induced apoptosis and inflammation in rat chondrocytes via inhibition of NF-kappaB signaling pathway. Ecdysterone 0-16 interleukin 1 beta Rattus norvegicus 28-45 24819928-6 2014 RESULTS: Treatment with 5 mg/kg AZT resulted in reduced MPO (p<0.05) and IL-1beta (p<0.05), increased levels of IL-10 (p<0.05), and reduced expression of MMP-2, MMP-9, COX-2, RANK, RANKL, cathepsin K, and increased expression of OPG. azilsartan 32-35 interleukin 1 beta Rattus norvegicus 76-84 24482148-8 2014 The expression levels of NMDAR1, TNF-alpha, IL-1beta, and IL-6 were significantly upregulated after treatment with 6-OHDA. Oxidopamine 115-121 interleukin 1 beta Rattus norvegicus 44-52 24576740-7 2014 Further studies showed osthole could decrease tumor necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta) levels in the lungs. osthol 23-30 interleukin 1 beta Rattus norvegicus 90-107 24576740-7 2014 Further studies showed osthole could decrease tumor necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta) levels in the lungs. osthol 23-30 interleukin 1 beta Rattus norvegicus 109-117 24482148-9 2014 The 6-OHDA-stimulated mRNA and protein levels of the proinflammatory cytokines NMDAR1, TNF-alpha, IL-1beta, and IL-6 were reduced by simvastatin. Oxidopamine 4-10 interleukin 1 beta Rattus norvegicus 98-106 24482148-9 2014 The 6-OHDA-stimulated mRNA and protein levels of the proinflammatory cytokines NMDAR1, TNF-alpha, IL-1beta, and IL-6 were reduced by simvastatin. Simvastatin 133-144 interleukin 1 beta Rattus norvegicus 98-106 24482148-10 2014 Silencing of NMDAR1 with siRNA decreased the NMDAR1, TNF-alpha, IL-1beta, and IL-6 mRNA and protein expression levels in 6-OHDA-stimulated PC12 cells. Oxidopamine 121-127 interleukin 1 beta Rattus norvegicus 64-72 24632017-6 2014 In addition, we also found that HCE inhibited interleukin-1 beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) expression, as well as IDO activity in frontal cortex and hippocampus, which were increased in rats exposed to CUMS. HCE 32-35 interleukin 1 beta Rattus norvegicus 46-64 24415531-6 2014 DAS also inhibited inflammation by suppressing interleukin-1beta and TNF-alpha through the inhibition of ROS-induced PI3K/Akt and the downstream NF-kappaB and activator protein-1. allyl sulfide 0-3 interleukin 1 beta Rattus norvegicus 47-64 24415531-6 2014 DAS also inhibited inflammation by suppressing interleukin-1beta and TNF-alpha through the inhibition of ROS-induced PI3K/Akt and the downstream NF-kappaB and activator protein-1. Reactive Oxygen Species 105-108 interleukin 1 beta Rattus norvegicus 47-64 24584301-9 2014 Further analyses demonstrated that the SAP-D group had lower levels of serum amylase, lipase and pro-inflammatory cytokines, including TNF-alpha and IL-1beta, and a decreased MPO activity and MDA content 3, 6 and 12 h subsequent to the infusion of sodium taurocholate compared with the SAP group (SAP). BENSULIDE 39-42 interleukin 1 beta Rattus norvegicus 149-157 24530657-8 2014 Compared with the TBI group, taurine significantly suppressed growth-related oncogene (GRO/KC) and interleukin (IL)-1beta levels while elevating the levels of regulated on activation, normal T cell expressed and secreted (RANTES) at 1day. Taurine 29-36 interleukin 1 beta Rattus norvegicus 62-121 24632017-6 2014 In addition, we also found that HCE inhibited interleukin-1 beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) expression, as well as IDO activity in frontal cortex and hippocampus, which were increased in rats exposed to CUMS. HCE 32-35 interleukin 1 beta Rattus norvegicus 66-74 24576725-6 2014 Treatment with PVN infusion of TEMP attenuated the overexpression of gp91(phox), ACE and IL-1beta within the PVN, and decreased sympathetic activity and MAP in ANG II-infused rats. tempol 31-35 interleukin 1 beta Rattus norvegicus 89-97 24751148-15 2014 CONCLUSION: The results indicate that compromised BSCB caused by I/R injury lead to spinal microglial activation and TLR4, its membrane-bound receptor, up-regulation, which then initiate neuro-inflammation and neuro-apoptosis via NF-kappaB/ IL-1beta pathway. bscb 50-54 interleukin 1 beta Rattus norvegicus 241-249 24751148-16 2014 To inhibit the positive feedback loop of TLR4-microglia-NF-kappaB/ IL-1beta pathway by minocycline, TAK-242 (TLR4 inhibitor) and pyrrolidine dithiocarbamate (PDTC, NF-kappaB inhibitor) may provide new targets for treating I/R injury in clinic. Minocycline 87-98 interleukin 1 beta Rattus norvegicus 67-75 24751148-16 2014 To inhibit the positive feedback loop of TLR4-microglia-NF-kappaB/ IL-1beta pathway by minocycline, TAK-242 (TLR4 inhibitor) and pyrrolidine dithiocarbamate (PDTC, NF-kappaB inhibitor) may provide new targets for treating I/R injury in clinic. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 100-107 interleukin 1 beta Rattus norvegicus 67-75 24708631-7 2014 RESULTS: In endotoxemic animals with epidural saline, LPS significantly increased the interleukin-1beta plasma concentration (48%), the expression of endothelial adhesion molecules E-selectin (34%) and ICAM-1 (42%), and the number of adherent leukocytes (40%) with an increase in intestinal myeloperoxidase activity (26%) and tissue edema (75%) when compared to healthy controls. Sodium Chloride 46-52 interleukin 1 beta Rattus norvegicus 86-103 24571985-4 2014 When Dex was subcutaneously injected 1 h after we administered an intraperitoneal lipopolysaccharide (LPS) challenge, neutrophil infiltration and proinflammatory Il1b, Il6, and Tnfa expression in rat placenta were significantly reduced. Dexamethasone 5-8 interleukin 1 beta Rattus norvegicus 162-166 24146106-3 2014 The anti-inflammatory potential of fucoxanthin in the regulation of maleic dialdehyde (MDA), polymorphonuclear cells (PMNs), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-alpha), and cyclooxygenase-2 (COX-2) was determined by ELISA. fucoxanthin 35-46 interleukin 1 beta Rattus norvegicus 125-142 24754049-5 2014 Treatment of primary mouse PAC or the rat AR42J PAC line with ethanol or CTGF/CCN2 resulted in enhanced expression of IL-1b or CCL3. Ethanol 62-69 interleukin 1 beta Rattus norvegicus 118-123 24146106-4 2014 Fucoxanthin significantly inhibited obesity-induced upregulation of the production of IL-1beta, TNF-alpha, iNOS, and COX-2. fucoxanthin 0-11 interleukin 1 beta Rattus norvegicus 86-94 24262494-10 2014 Up-regulated myeloperoxidase, IL-1beta, IL-6 and TNF-alpha expression in cyclophosphamide treated rats was also suppressed in rebamipide treated rats. Cyclophosphamide 73-89 interleukin 1 beta Rattus norvegicus 30-38 24462494-4 2014 The results showed that tangeretin decreased the production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and interleukin-6 (IL-6), in a dose-dependent manner. tangeretin 24-34 interleukin 1 beta Rattus norvegicus 148-166 24462494-4 2014 The results showed that tangeretin decreased the production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and interleukin-6 (IL-6), in a dose-dependent manner. tangeretin 24-34 interleukin 1 beta Rattus norvegicus 168-176 24491957-7 2014 Minocycline blocked changes in microglial morphology and IL-1beta release induced by hyperoxia. Minocycline 0-11 interleukin 1 beta Rattus norvegicus 57-65 24491314-10 2014 Subsequently, it ameliorated high fructose-caused hypothalamic inflammatory lesions in rats by suppressing the activation of hypothalamic nuclear factor kappaB (NF-kappaB) pathway and NOD-like receptor 3 (NLRP3) inflammasome with interleukin 1beta maturation. Fructose 34-42 interleukin 1 beta Rattus norvegicus 230-247 24262494-10 2014 Up-regulated myeloperoxidase, IL-1beta, IL-6 and TNF-alpha expression in cyclophosphamide treated rats was also suppressed in rebamipide treated rats. rebamipide 126-136 interleukin 1 beta Rattus norvegicus 30-38 23943137-5 2014 Estradiol decreased the mRNA levels of IL6, IP10, TNFalpha, and IL1beta in male but not in female cultures treated with DMT. Dimethoate 120-123 interleukin 1 beta Rattus norvegicus 64-71 24014157-5 2014 The results demonstrated that the levels of interleukin-1 beta (IL-1beta) were increased in the cortex of streptozocin (STZ)-induced diabetic rats. Streptozocin 106-118 interleukin 1 beta Rattus norvegicus 44-62 24014157-5 2014 The results demonstrated that the levels of interleukin-1 beta (IL-1beta) were increased in the cortex of streptozocin (STZ)-induced diabetic rats. Streptozocin 106-118 interleukin 1 beta Rattus norvegicus 64-72 24014157-5 2014 The results demonstrated that the levels of interleukin-1 beta (IL-1beta) were increased in the cortex of streptozocin (STZ)-induced diabetic rats. Streptozocin 120-123 interleukin 1 beta Rattus norvegicus 44-62 24014157-5 2014 The results demonstrated that the levels of interleukin-1 beta (IL-1beta) were increased in the cortex of streptozocin (STZ)-induced diabetic rats. Streptozocin 120-123 interleukin 1 beta Rattus norvegicus 64-72 24014157-6 2014 The levels of mature IL-1beta and IL-18 were also elevated in culture medium of neurons treated with high glucose (50 mM). Glucose 106-113 interleukin 1 beta Rattus norvegicus 21-29 23943137-5 2014 Estradiol decreased the mRNA levels of IL6, IP10, TNFalpha, and IL1beta in male but not in female cultures treated with DMT. Estradiol 0-9 interleukin 1 beta Rattus norvegicus 64-71 24667059-13 2014 Asiaticoside has potential for hydrogen peroxide cytotoxicity, and the caspase-3 activity increased with increasing asiaticoside dose in MCF-7 cells treated for 48 h. The expression of the cytokines TNF-alpha and IL-1beta was significantly decreased and correlated with MIBI uptake ratios in vitro and in vivo after asiaticoside administration. asiaticoside 116-128 interleukin 1 beta Rattus norvegicus 213-221 24406203-5 2014 Pretreatment with H89, a protein kinase A (PKA) inhibitor, blocked IL-1beta-induced mechanical allodynia but not thermal hyperalgesia. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 18-21 interleukin 1 beta Rattus norvegicus 67-75 24406203-6 2014 In contrast, pretreatment with chelerythrine, a protein kinase C (PKC) inhibitor, inhibited IL-1beta-induced thermal hyperalgesia. chelerythrine 31-44 interleukin 1 beta Rattus norvegicus 92-100 24406203-7 2014 Subcutaneous injections of 2% lidocaine, a local anesthetic agent, blocked IL-1beta-induced thermal hyperalgesia but not IL-1beta-induced mechanical allodynia. Lidocaine 30-39 interleukin 1 beta Rattus norvegicus 75-83 24406203-8 2014 In the resiniferatoxin (RTX)-pretreated rats, a subcutaneous injection of IL-1beta did not produce thermal hyperalgesia due to the depletion of TRPV1 in the primary afferent fibers. resiniferatoxin 24-27 interleukin 1 beta Rattus norvegicus 74-82 24661619-9 2014 DAPT and aspirin given only by regimen 2 and 3 reduced NICD, IL-6 and IL-1beta in the ischemic penumbral cortex. dapt 0-4 interleukin 1 beta Rattus norvegicus 70-78 24661619-9 2014 DAPT and aspirin given only by regimen 2 and 3 reduced NICD, IL-6 and IL-1beta in the ischemic penumbral cortex. Aspirin 9-16 interleukin 1 beta Rattus norvegicus 70-78 24519543-2 2014 N-acetylcysteine (NAC) and selenium (Se) display neuroprotective activities mediated at least in part by their antioxidant and anti-inflammatory properties although there is no report on oxidative stress, antioxidant vitamin, interleukin-1 beta (IL)-1beta and IL-4 levels in brain and blood of TBI-induced rats. Acetylcysteine 18-21 interleukin 1 beta Rattus norvegicus 226-255 24519543-2 2014 N-acetylcysteine (NAC) and selenium (Se) display neuroprotective activities mediated at least in part by their antioxidant and anti-inflammatory properties although there is no report on oxidative stress, antioxidant vitamin, interleukin-1 beta (IL)-1beta and IL-4 levels in brain and blood of TBI-induced rats. Selenium 27-35 interleukin 1 beta Rattus norvegicus 226-255 24519543-2 2014 N-acetylcysteine (NAC) and selenium (Se) display neuroprotective activities mediated at least in part by their antioxidant and anti-inflammatory properties although there is no report on oxidative stress, antioxidant vitamin, interleukin-1 beta (IL)-1beta and IL-4 levels in brain and blood of TBI-induced rats. Selenium 37-39 interleukin 1 beta Rattus norvegicus 226-255 24519543-9 2014 The lipid peroxidation and IL-1beta values were decreased by NAC and Se treatments. Acetylcysteine 61-64 interleukin 1 beta Rattus norvegicus 27-35 24446128-7 2014 Compared to control, formalin-injected prostate exhibited a 2.5-fold to sixfold increased protein expression of IL-1alpha, IL-1beta, and IL-6. Formaldehyde 21-29 interleukin 1 beta Rattus norvegicus 123-131 24667059-13 2014 Asiaticoside has potential for hydrogen peroxide cytotoxicity, and the caspase-3 activity increased with increasing asiaticoside dose in MCF-7 cells treated for 48 h. The expression of the cytokines TNF-alpha and IL-1beta was significantly decreased and correlated with MIBI uptake ratios in vitro and in vivo after asiaticoside administration. asiaticoside 316-328 interleukin 1 beta Rattus norvegicus 213-221 24667059-13 2014 Asiaticoside has potential for hydrogen peroxide cytotoxicity, and the caspase-3 activity increased with increasing asiaticoside dose in MCF-7 cells treated for 48 h. The expression of the cytokines TNF-alpha and IL-1beta was significantly decreased and correlated with MIBI uptake ratios in vitro and in vivo after asiaticoside administration. 2-methoxyisobutylisonitrile 270-274 interleukin 1 beta Rattus norvegicus 213-221 24425765-0 2014 IL-1beta hampers glucose-stimulated insulin secretion in Cohen diabetic rat islets through mitochondrial cytochrome c oxidase inhibition by nitric oxide. Glucose 17-24 interleukin 1 beta Rattus norvegicus 0-8 24457042-9 2014 Moreover, in saline-treated rats basal hypothalamic Il-1beta and CD11b expression were positively correlated with tumor weight; heavier tumors, in turn, were characterized by more inflammatory, necrotic, and granulation tissue. Sodium Chloride 13-19 interleukin 1 beta Rattus norvegicus 52-60 24425765-8 2014 Interleukin-1beta (2.5 U/ml) reduced GSIS and COX activity in CDs islets. Cadmium 62-65 interleukin 1 beta Rattus norvegicus 0-17 24425765-9 2014 Exposure to 10 U/ml interleukin-1beta decreased GSIS and COX activity in both CDs and CDr islets, inducing a similar nitrite production. Cadmium 78-81 interleukin 1 beta Rattus norvegicus 20-37 24650557-7 2014 Sitagliptin-treated diabetic rats presented a reduced pancreas Bax/Bcl2 ratio, suggestive of an antiapoptotic effect; in addition, sitagliptin was able to completely reduce (p < 0.001) the pancreas overexpression of IL-1beta and TRIB3 found in the untreated diabetic animals; and promoted a significant (p < 0.001) overexpression of VEGF and PCNA. Sitagliptin Phosphate 0-11 interleukin 1 beta Rattus norvegicus 219-227 24650557-7 2014 Sitagliptin-treated diabetic rats presented a reduced pancreas Bax/Bcl2 ratio, suggestive of an antiapoptotic effect; in addition, sitagliptin was able to completely reduce (p < 0.001) the pancreas overexpression of IL-1beta and TRIB3 found in the untreated diabetic animals; and promoted a significant (p < 0.001) overexpression of VEGF and PCNA. Sitagliptin Phosphate 131-142 interleukin 1 beta Rattus norvegicus 219-227 24217958-3 2014 RESULTS: Binge-like ethanol administration to adolescent rats increased the gene expression of TLR4 and TLR2 in the prefrontal cortex (PFC), as well as inflammatory cytokines TNFalpha and IL-1beta. Ethanol 20-27 interleukin 1 beta Rattus norvegicus 188-196 24425765-0 2014 IL-1beta hampers glucose-stimulated insulin secretion in Cohen diabetic rat islets through mitochondrial cytochrome c oxidase inhibition by nitric oxide. Nitric Oxide 140-152 interleukin 1 beta Rattus norvegicus 0-8 24425765-9 2014 Exposure to 10 U/ml interleukin-1beta decreased GSIS and COX activity in both CDs and CDr islets, inducing a similar nitrite production. cdr 86-89 interleukin 1 beta Rattus norvegicus 20-37 24425765-9 2014 Exposure to 10 U/ml interleukin-1beta decreased GSIS and COX activity in both CDs and CDr islets, inducing a similar nitrite production. Nitrites 117-124 interleukin 1 beta Rattus norvegicus 20-37 24555878-10 2014 Administration of GTS suppressed the postincision rise in serum IL-1beta levels and NMDA inhibited the increase in the MWT compared with GTS alone. Glutathionesulfonic acid 18-21 interleukin 1 beta Rattus norvegicus 64-72 24425765-12 2014 N(omega)-nitro-l-arginine and copper prevented the deleterious effect of interleukin-1beta on COX activity and GSIS. Nitroarginine 0-25 interleukin 1 beta Rattus norvegicus 73-90 24425765-12 2014 N(omega)-nitro-l-arginine and copper prevented the deleterious effect of interleukin-1beta on COX activity and GSIS. Copper 30-36 interleukin 1 beta Rattus norvegicus 73-90 24308861-9 2014 HU308 reduced this effect after LPS injection and decreased pro-inflammatory mediators: TNF-alpha, IL-1beta, IL-6, CCL5 and CXCL2. HU 308 0-5 interleukin 1 beta Rattus norvegicus 99-107 24309633-6 2014 Rats exposed to sucrose exhibited both increased hippocampal inflammation (TNF-alpha and IL-1beta mRNA) and oxidative stress, as indicated by an upregulation of NRF1 mRNA compared to control rats. Sucrose 16-23 interleukin 1 beta Rattus norvegicus 89-97 24741183-7 2014 In addition, also statistically insignificant, the bladder tissue expressions of IL-1beta were lower in ketamine and/or mesna-receiving groups (P > 0,05). Ketamine 104-112 interleukin 1 beta Rattus norvegicus 81-89 24741183-7 2014 In addition, also statistically insignificant, the bladder tissue expressions of IL-1beta were lower in ketamine and/or mesna-receiving groups (P > 0,05). Mesna 120-125 interleukin 1 beta Rattus norvegicus 81-89 24586695-13 2014 Significant increased (P<0.05) in the serum levels of the inflammatory cytokines TNF-alpha and IL-1beta in PE and PE-PTZ groups, and decreased (P<0.05) in their levels following MgSO4 administration. Pentylenetetrazole 120-123 interleukin 1 beta Rattus norvegicus 98-106 24956851-10 2014 CONCLUSION: Paeonol could inhibit IL-1beta and TNF-alpha expression to protect VECs from being injured by LPS, and reduce ICAM-1 expression to inhibit the adhesion between VECs and monocytes. paeonol 12-19 interleukin 1 beta Rattus norvegicus 34-42 25204188-8 2014 Paeoniflorin was able to inhibit the expression of IL-1beta, NF-kappaB p65, TNF-alpha, PGE2 of synovial tissue in CIA rats. peoniflorin 0-12 interleukin 1 beta Rattus norvegicus 51-59 24490798-5 2014 RESULTS: Ilantide bound IL-1RI, inhibited the IL-1beta-induced activation of NF-kappaB, and inhibited the secretion of TNF-alpha in vitro. ilantide 9-17 interleukin 1 beta Rattus norvegicus 46-54 24389027-12 2014 Moreover, IL-1beta and TNF-alpha were downregulated (both P<0.05 or P<0.01) and IkappaBalpha was upregulated by the (FA+LZ+THP)-medicated serum (P<0.01). tetrahydropalmatine 129-132 interleukin 1 beta Rattus norvegicus 10-18 24551070-11 2014 Ethanol and HMGB1 treatment increased mRNA expression of proinflammatory cytokines TNFalpha and IL-1beta as well as toll-like receptor 4 (TLR4). Ethanol 0-7 interleukin 1 beta Rattus norvegicus 96-104 24519204-9 2014 RESULTS: After transplantation, a significant reduction in the levels of tumor necrosis factor-alpha and IL-1beta was observed in the group that received methylprednisolone (p=0.0084 and p=0.0155, respectively). Methylprednisolone 154-172 interleukin 1 beta Rattus norvegicus 105-113 24496680-14 2014 The mRNA and protein expression of IL-1beta, IL-6, and TNF-alpha was down-regulated in the colonic tissue of rats topically treated with 5-ASA, significantly lower than those from rats treated with oral 5-ASA or Etiasa. Mesalamine 137-142 interleukin 1 beta Rattus norvegicus 35-43 24337018-9 2014 PCPA markedly attenuated MCT-induced pulmonary vascular remodeling and lung inflammation, inhibited the expression of Tph-1 and SERT and suppressed the expression of MMP-2/-9, TIMP-1/-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1). Fenclonine 0-4 interleukin 1 beta Rattus norvegicus 187-204 24337018-9 2014 PCPA markedly attenuated MCT-induced pulmonary vascular remodeling and lung inflammation, inhibited the expression of Tph-1 and SERT and suppressed the expression of MMP-2/-9, TIMP-1/-2, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 (ICAM-1). Fenclonine 0-4 interleukin 1 beta Rattus norvegicus 206-214 24286347-0 2014 Berberine ameliorates cartilage degeneration in interleukin-1beta-stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling. Berberine 0-9 interleukin 1 beta Rattus norvegicus 48-65 24286347-4 2014 Here, we assessed the effects of berberine on cartilage degeneration in interleukin-1beta (IL-1beta)-stimulated rat chondrocytes and in a rat model of OA. Berberine 33-42 interleukin 1 beta Rattus norvegicus 72-89 24286347-5 2014 The results of an MTT assay and western blotting analysis showed that berberine attenuated the inhibitory effect of IL-1beta on the cell viability and proliferating cell nuclear antigen expression in rat chondrocytes. Berberine 70-79 interleukin 1 beta Rattus norvegicus 116-124 24286347-6 2014 Furthermore, berberine activated Akt, which triggered p70S6K/S6 pathway and up-regulated the levels of aggrecan and Col II expression in IL-1beta-stimulated rat chondrocytes. Berberine 13-22 interleukin 1 beta Rattus norvegicus 137-145 24286347-8 2014 The data thus strongly suggest that berberine may ameliorate cartilage degeneration from OA by promoting cell survival and matrix production of chondrocytes, which was partly attributed to the activation of Akt in IL-1beta-stimulated articular chondrocytes and in a rat OA model. Berberine 36-45 interleukin 1 beta Rattus norvegicus 214-222 24496680-14 2014 The mRNA and protein expression of IL-1beta, IL-6, and TNF-alpha was down-regulated in the colonic tissue of rats topically treated with 5-ASA, significantly lower than those from rats treated with oral 5-ASA or Etiasa. Mesalamine 203-208 interleukin 1 beta Rattus norvegicus 35-43 24496680-14 2014 The mRNA and protein expression of IL-1beta, IL-6, and TNF-alpha was down-regulated in the colonic tissue of rats topically treated with 5-ASA, significantly lower than those from rats treated with oral 5-ASA or Etiasa. etiasa 212-218 interleukin 1 beta Rattus norvegicus 35-43 24234420-8 2014 Related to immune response, resveratrol pretreatment reduced pro-inflammatory cytokine IL-1beta levels and increased anti-inflammatory cytokine IL-10 levels. Resveratrol 28-39 interleukin 1 beta Rattus norvegicus 87-95 24622834-9 2014 Moreover induction of gastric ulcer by ethanol significantly increased mucosal expression of mRNA for COX-2, IL-1beta and TNF-alpha. Ethanol 39-46 interleukin 1 beta Rattus norvegicus 109-117 23884618-2 2014 Previously, we have shown that after 24 h of dichlorvos exposure, microglia become activated and secrete pro-inflammatory molecules like nitric oxide, tumour necrosis factor-alpha and interleukin-1beta. Dichlorvos 45-55 interleukin 1 beta Rattus norvegicus 184-201 24291733-9 2014 Moreover, ibuprofen treatment markedly reduced the activity, protein, and mRNA levels of BACE1, AGE level, protein expression of RAGE, COX-2, and iNOS in the brain, and interleukin 1beta level in serum, while increasing the protein and mRNA expression of PPARgamma in the brain of diabetic rats. Ibuprofen 10-19 interleukin 1 beta Rattus norvegicus 169-186 24338284-10 2014 The non-steroid anti-inflammatory drug metamizole also reversed completely the action of IL-1beta (187-207). Steroids 8-15 interleukin 1 beta Rattus norvegicus 89-97 24338284-10 2014 The non-steroid anti-inflammatory drug metamizole also reversed completely the action of IL-1beta (187-207). Dipyrone 39-49 interleukin 1 beta Rattus norvegicus 89-97 24338284-12 2014 This effect is mediated through prostaglandin E2 stimulation and other mechanisms may also be involved in the action of IL-1beta (187-207). Dinoprostone 32-48 interleukin 1 beta Rattus norvegicus 120-128 24226635-5 2014 The O2 treatment was >95% O2 for 7 d, followed by 60% O2 for 14 d. RESULTS: Rat pups born to LPS-injected dams exhibited significantly higher lung interferon-gamma and interleukin-1beta (IL-1beta) on postnatal day 7 than the pups born to NS-injected dams. Oxygen 4-6 interleukin 1 beta Rattus norvegicus 171-188 24672948-0 2014 [Effect of Tetramethyl pyrazine on serum levels of IL-1beta, IL-6, and IL-2, and NO and PGE2 in the synovial fluid of CIA rats: an experimental research]. tetramethylpyrazine 11-31 interleukin 1 beta Rattus norvegicus 51-59 24226635-5 2014 The O2 treatment was >95% O2 for 7 d, followed by 60% O2 for 14 d. RESULTS: Rat pups born to LPS-injected dams exhibited significantly higher lung interferon-gamma and interleukin-1beta (IL-1beta) on postnatal day 7 than the pups born to NS-injected dams. Oxygen 4-6 interleukin 1 beta Rattus norvegicus 190-198 24498101-11 2014 Our results suggest that following a hypoxic insult, astrocytes in the PWM of neonatal rats produce inflammatory cytokines such as TNF-alpha and IL-1beta, which induce apoptosis of OLs via their corresponding receptors associated with them. N-biotin-C-Co4(mu3-O)4(Py)4(H2O)4-beta-alanine 181-184 interleukin 1 beta Rattus norvegicus 145-153 24184413-2 2014 In addition to providing a summary of stress effects on neuroimmune changes within the CNS, we present a series of experiments that characterize stress effects on members of the interleukin-1beta (IL-1) super-family and other inflammatory-related genes in key structures comprising the HPA axis (PVN, pituitary and adrenal glands), followed by a series of experiments examining the impact of exogenous hormone administration (CRH and ACTH) and dexamethasone on the expression of inflammatory-related genes in adult male Sprague-Dawley rats. Dexamethasone 444-457 interleukin 1 beta Rattus norvegicus 178-195 25231848-9 2014 Enzyme-Linked Immunosorbent Assay (ELISA) revealed the significant increase of cytokine (IL-1beta, IL-6) levels in the repeated morphine treatment rats" cortex and hippocampus regions, which are both addiction-related brain areas. Morphine 128-136 interleukin 1 beta Rattus norvegicus 89-97 24447929-9 2014 At 32 h post-TBI phenoxybenzamine treated animals had significantly lower expression of pro-inflammatory signaling proteins CCL2, IL1beta, and MyD88, suggesting that phenoxybenzamine may exert a neuroprotective effect by reducing neuroinflammation after TBI. Phenoxybenzamine 17-33 interleukin 1 beta Rattus norvegicus 130-137 24447929-9 2014 At 32 h post-TBI phenoxybenzamine treated animals had significantly lower expression of pro-inflammatory signaling proteins CCL2, IL1beta, and MyD88, suggesting that phenoxybenzamine may exert a neuroprotective effect by reducing neuroinflammation after TBI. Phenoxybenzamine 166-182 interleukin 1 beta Rattus norvegicus 130-137 24871659-9 2014 CAE (8, 16, and 32 mg/kg) treatment significantly reduced the levels of TNFalpha, IL-1beta and PGE-2 in serum compared with the CIA group. ACE protocol 1 0-3 interleukin 1 beta Rattus norvegicus 82-90 23403542-13 2014 The inflammatory mediators (tumor necrosis factor alpha, interleukin 1beta, and interferon gamma) were significantly lower in the VNP-treated group than the control group (P < 0.05). ventricular natriuretic peptide, eel 130-133 interleukin 1 beta Rattus norvegicus 57-74 24064301-7 2014 In addition, S1P/S1P2-dependent upregulation of COX-2 led to significantly elevated PGE2 levels, which were further potentiated in the presence of Ang II and IL-1beta. Dinoprostone 84-88 interleukin 1 beta Rattus norvegicus 158-166 24095834-0 2014 Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1beta-stimulated rat fibroblasts. Arachidonic Acid 68-84 interleukin 1 beta Rattus norvegicus 99-116 24095834-3 2014 Treatment of 3Y1 cells with triacsin C, an ACSL inhibitor, markedly enhanced the IL-1beta-induced prostaglandin (PG) biosynthesis. triacsin C 28-38 interleukin 1 beta Rattus norvegicus 81-89 24095834-3 2014 Treatment of 3Y1 cells with triacsin C, an ACSL inhibitor, markedly enhanced the IL-1beta-induced prostaglandin (PG) biosynthesis. Prostaglandins 98-111 interleukin 1 beta Rattus norvegicus 81-89 24095834-3 2014 Treatment of 3Y1 cells with triacsin C, an ACSL inhibitor, markedly enhanced the IL-1beta-induced prostaglandin (PG) biosynthesis. Prostaglandins 113-115 interleukin 1 beta Rattus norvegicus 81-89 24963491-7 2014 PQ-induced TNF-alpha and IL-1beta secretion in BALF, increases of PaO2 in arterial blood, and MPO levels in the lung tissue were significantly reduced. Primaquine 0-2 interleukin 1 beta Rattus norvegicus 25-33 25088045-7 2014 Pretreatment with isoflurane suppressed renal NF-kappaB activation, leading to a reduction in proinflammatory molecules (high-mobility group box 1, interleukin-1beta, and tumor necrosis factor-alpha) both in the kidneys and circulation. Isoflurane 18-28 interleukin 1 beta Rattus norvegicus 148-165 23661600-0 2014 Ferulic acid in the treatment of post-diabetes testicular damage: relevance to the down regulation of apoptosis correlates with antioxidant status via modulation of TGF-beta1, IL-1beta and Akt signalling. ferulic acid 0-12 interleukin 1 beta Rattus norvegicus 176-184 24557329-6 2014 The mRNA expression and protein content of NF-kappaB, IL-1beta, IL-6 and TNF-alpha were significantly reduced in the triptolide-treated group compared with the control groups. triptolide 117-127 interleukin 1 beta Rattus norvegicus 54-62 23771723-7 2014 Moreover, administration of TGP (50 or 100 mg/kg/day) decreased the up-regulated levels of serum TNF-alpha and IL-1beta, and expression of TNF-alpha and IL-1beta mRNA and protein in colonic tissues, and increased the serum IL-10 and colonic IL-10 mRNA and protein level. tgp 28-31 interleukin 1 beta Rattus norvegicus 111-119 24316519-8 2014 Pre-treatment with minocycline and ketoconazole prevented the development of thermal hyperalgesia and the increase in IL-1beta, without significantly modifying serum corticosterone. Minocycline 19-30 interleukin 1 beta Rattus norvegicus 118-126 24316519-8 2014 Pre-treatment with minocycline and ketoconazole prevented the development of thermal hyperalgesia and the increase in IL-1beta, without significantly modifying serum corticosterone. Ketoconazole 35-47 interleukin 1 beta Rattus norvegicus 118-126 23771723-7 2014 Moreover, administration of TGP (50 or 100 mg/kg/day) decreased the up-regulated levels of serum TNF-alpha and IL-1beta, and expression of TNF-alpha and IL-1beta mRNA and protein in colonic tissues, and increased the serum IL-10 and colonic IL-10 mRNA and protein level. tgp 28-31 interleukin 1 beta Rattus norvegicus 153-161 23661600-7 2014 Our data indicated that significant reduction in the activity of apoptosis by using terminal deoxyuridine triphosphate nick end-labelling and reduced expression of transforming growth factor-beta1 and interleukin-1beta in the testis tissue of ferulic acid-treated diabetic rats. ferulic acid 243-255 interleukin 1 beta Rattus norvegicus 201-218 23771723-9 2014 TGP attenuates TNBS/ethanol-induced colitis in rats and its efficacy is similar to SASP, the potential mechanism might be related to the adjustment of Th1/Th2 cytokines polarization by decreasing pro-inflammatory cytokine TNF-alpha and IL-1beta, and increasing anti-inflammatory cytokine IL-10. tgp 0-3 interleukin 1 beta Rattus norvegicus 236-244 24931258-21 2014 On day 7 the expressions of TNF-alpha and IL-1beta in the thalidomide treatment group were lower than in the TNBS model group. Thalidomide 58-69 interleukin 1 beta Rattus norvegicus 42-50 24890166-17 2014 In vitro, GW501516 and over-expression of PPARbeta/delta attenuated gene expression of TNF-alpha, IL-1beta and IL-6 in alveolar macrophages. GW 501516 10-18 interleukin 1 beta Rattus norvegicus 98-106 24394943-5 2014 In addition, significant anti-inflammatory effects were observed in trikatu treated adjuvant induced arthritic rats by a reduction in the levels of circulating immune complexes and inflammatory mediators (TNF-alpha and Interleukin-1beta). trikatu 68-75 interleukin 1 beta Rattus norvegicus 219-236 24931258-21 2014 On day 7 the expressions of TNF-alpha and IL-1beta in the thalidomide treatment group were lower than in the TNBS model group. Trinitrobenzenesulfonic Acid 109-113 interleukin 1 beta Rattus norvegicus 42-50 24931258-22 2014 On day 14, the expressions of TNF-alpha and IL-1beta in the thalidomide treatment group were significantly lower than in the TNBS model group (P < 0.05). Thalidomide 60-71 interleukin 1 beta Rattus norvegicus 44-52 24725086-0 2014 Phosphatidylserine and curcumin act synergistically to down-regulate release of interleukin-1beta from lipopolysaccharide-stimulated cortical primary microglial cells. Phosphatidylserines 0-18 interleukin 1 beta Rattus norvegicus 80-97 24762601-16 2014 Treatment with M8I or DEX, however, attenuated sepsis induced histopathological changes in the heart, and was associated with significant reductions in serum and myocardial levels of TNF-alpha and IL-1beta (P < 0.05). m8i 15-18 interleukin 1 beta Rattus norvegicus 197-205 24725086-0 2014 Phosphatidylserine and curcumin act synergistically to down-regulate release of interleukin-1beta from lipopolysaccharide-stimulated cortical primary microglial cells. Curcumin 23-31 interleukin 1 beta Rattus norvegicus 80-97 24762601-16 2014 Treatment with M8I or DEX, however, attenuated sepsis induced histopathological changes in the heart, and was associated with significant reductions in serum and myocardial levels of TNF-alpha and IL-1beta (P < 0.05). Dexamethasone 22-25 interleukin 1 beta Rattus norvegicus 197-205 24725086-9 2014 PS and curcumin inhibited the release of interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha induced by lipopolysaccharide. Phosphatidylserines 0-2 interleukin 1 beta Rattus norvegicus 41-63 24725086-9 2014 PS and curcumin inhibited the release of interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha induced by lipopolysaccharide. Curcumin 7-15 interleukin 1 beta Rattus norvegicus 41-63 24448467-7 2014 Paracetamol decreased COX-2 activity, levels of PGE2, TNF-alpha and IL-1beta and caused up-regulation of CB1 receptors. Acetaminophen 0-11 interleukin 1 beta Rattus norvegicus 68-76 24140713-6 2014 Correspondingly, hemin significantly enhanced the antiinflammatory macrophage-M2 phenotype, IL-10, adiponectin, HO-1, HO activity, and atrial natriuretic-peptide (ANP), a substance that abates TNF-alpha, IL-6, and IL-1beta, with parallel increase of urinary cGMP, a surrogate marker of ANP. Hemin 17-22 interleukin 1 beta Rattus norvegicus 214-222 24140713-9 2014 Because aldosterone stimulate NF-kappaB, which activates cytokines like TNF-alpha, IL-6, IL-1beta that in turn stimulate chemokines such as MCP-1 and MIP-1alpha to promote macrophage-M1 infiltration, the hemin-dependent potentiation of the HO-adiponectin-ANP axis may account for reduced macrophage infiltration and inflammatory insults in streptozotocin-diabetic rats. Aldosterone 8-19 interleukin 1 beta Rattus norvegicus 89-97 24140713-9 2014 Because aldosterone stimulate NF-kappaB, which activates cytokines like TNF-alpha, IL-6, IL-1beta that in turn stimulate chemokines such as MCP-1 and MIP-1alpha to promote macrophage-M1 infiltration, the hemin-dependent potentiation of the HO-adiponectin-ANP axis may account for reduced macrophage infiltration and inflammatory insults in streptozotocin-diabetic rats. Streptozocin 340-354 interleukin 1 beta Rattus norvegicus 89-97 25345510-4 2014 The present study aimed to investigate the result of non-observable adverse effect level dose of a highly toxic OPC, terbufos sulfone (TBS), on sub-chronic exposure on the status of proinflammatory cytokines; interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha in rats brain. terbufos sulfone 117-133 interleukin 1 beta Rattus norvegicus 209-226 25345510-4 2014 The present study aimed to investigate the result of non-observable adverse effect level dose of a highly toxic OPC, terbufos sulfone (TBS), on sub-chronic exposure on the status of proinflammatory cytokines; interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha in rats brain. terbufos sulfone 135-138 interleukin 1 beta Rattus norvegicus 209-226 23786480-0 2014 Progesterone inhibits the expression of cycloxygenase-2 and interleukin-1beta in neonatal rats with hypoxic ischemic brain damage. Progesterone 0-12 interleukin 1 beta Rattus norvegicus 60-77 24563432-0 2014 Effect of SB203580 on pathologic change of pancreatic tissue and expression of TNF-alpha and IL-1beta in rats with severe acute pancreatitis. SB 203580 10-18 interleukin 1 beta Rattus norvegicus 93-101 24563432-1 2014 OBJECTIVE: This study aimed to investigate the effect of SB203580 which is the inhibitor of p38 mitogen-activated protein kinase on pathologic change of pancreatic tissue and expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1b) in rats with severe acute pancreatitis (SAP), Hematoxylin-eosin (HE) staining and immunohistochemistry were carried out in the present study. SB 203580 57-65 interleukin 1 beta Rattus norvegicus 233-251 24563432-1 2014 OBJECTIVE: This study aimed to investigate the effect of SB203580 which is the inhibitor of p38 mitogen-activated protein kinase on pathologic change of pancreatic tissue and expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1b) in rats with severe acute pancreatitis (SAP), Hematoxylin-eosin (HE) staining and immunohistochemistry were carried out in the present study. SB 203580 57-65 interleukin 1 beta Rattus norvegicus 253-258 24563432-11 2014 CONCLUSIONS: Those data suggest that SB203580, down regulating the expression of pro-inflammatory mediators such as TNF-alpha and IL-1beta, then through p38 MAPK signaling pathway inhibition, plays an important role in the treatment of SAP. SB 203580 37-45 interleukin 1 beta Rattus norvegicus 130-138 24348792-9 2014 Paeoniflorin significantly improved the disease resistant ability of RA rats and reduced the levels of the inflammatory cytokines, IL-1beta and TNF-alpha, thereby inhibiting inflammation and bone erosion in the rats with CIA. peoniflorin 0-12 interleukin 1 beta Rattus norvegicus 131-139 24872832-6 2014 We found that pretreatment with ligustrazine for 1 month recovered the structural distortion of the degenerative disc; inhibited the expression of type X collagen, matrix metalloproteinase (MMP)-13, and MMP3; upregulated type II collagen; and decreased IL-1 beta , cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) expression. tetramethylpyrazine 32-44 interleukin 1 beta Rattus norvegicus 253-262 23786480-10 2014 Compared with the HI group, the PROG group showed noticeably lower expression and contents of COX-2 and IL-1beta (P < 0.05). hi 18-20 interleukin 1 beta Rattus norvegicus 104-112 24211397-15 2014 The reduced values of TNF-alpha, IL-1beta, COX-2, PEG2, inducible nitric oxide synthase (iNOS) and nitric oxide (NO) were observed both in AHT and TFA treated groups. Trifluoroacetic Acid 147-150 interleukin 1 beta Rattus norvegicus 33-41 24126566-7 2014 Pretreatment with MHBFC decreased the infarction areas, the malondialdehyde, IL-1beta and IL-6 levels, the expression of caspase-3, NF-kappaBp65, and intercellular adhesion molecule-1. 17-methoxyl-7-hydroxy-benzene-furanchalcone 18-23 interleukin 1 beta Rattus norvegicus 77-85 24817793-7 2014 Sitagliptin also decreased IL-1beta and TNF-alpha levels, as well as, prevented the increase of BAX/Bcl-2 ratio, Bid protein levels, and TUNEL-positive cells which indicates protective effects against inflammation and proapoptotic state in the kidney of diabetic rats, respectively. Sitagliptin Phosphate 0-11 interleukin 1 beta Rattus norvegicus 27-35 23988196-9 2014 In addition, circulating tumor necrosis factor alpha, interleukin 1beta was greatly reduced in Tadalafil group versus the no treatment group. Tadalafil 95-104 interleukin 1 beta Rattus norvegicus 54-71 24007817-10 2014 RESULTS: Plasma tumor necrosis factor alpha or interleukin 1beta levels increased significantly in the I/R group (P < 0.01 compared with sham group) and decreased significantly in the DEX group (P < 0.01 compared with I/R group). Dexmedetomidine 187-190 interleukin 1 beta Rattus norvegicus 47-64 24623960-3 2014 We have recently identified gambogic acid as a promising therapeutic candidate to simultaneously block IL-1beta and TNF secretion. gambogic acid 28-41 interleukin 1 beta Rattus norvegicus 103-111 25152897-8 2014 Likewise, glycyrrhizin was able to reduce the IL-1beta and MCP-1 mRNA levels. Glycyrrhizic Acid 10-22 interleukin 1 beta Rattus norvegicus 46-54 23981709-7 2014 RESULTS: Celastrol significantly suppressed elevation of the renal function markers and the lipid peroxidation level, alleviated renal tubular damage, and decreased the levels of tumor necrosis factor-alpha, interleukin-1beta, and monocyte chemotactic protein-1 (MCP-1) messenger RNA in kidney caused by IR. celastrol 9-18 interleukin 1 beta Rattus norvegicus 208-225 24028150-0 2014 Emodin inhibits ATP-induced IL-1beta secretion, ROS production and phagocytosis attenuation in rat peritoneal macrophages via antagonizing P2X7 receptor. Adenosine Triphosphate 16-19 interleukin 1 beta Rattus norvegicus 28-36 25323082-7 2014 Perioperative treatment with propofol and dex significantly suppressed I/R-up regulated TNF-alpha and IL-1beta expressions, ameliorated AKT1 expression and caspase-3 activity. Propofol 29-37 interleukin 1 beta Rattus norvegicus 102-110 25323082-7 2014 Perioperative treatment with propofol and dex significantly suppressed I/R-up regulated TNF-alpha and IL-1beta expressions, ameliorated AKT1 expression and caspase-3 activity. dex 42-45 interleukin 1 beta Rattus norvegicus 102-110 24211709-0 2014 The specific PKR inhibitor C16 prevents apoptosis and IL-1beta production in an acute excitotoxic rat model with a neuroinflammatory component. Palmitic Acid 27-30 interleukin 1 beta Rattus norvegicus 54-62 24683438-6 2014 Furthermore, 6 weeks of running significantly decreased TNBS-induced inflammatory markers, including extent of lesions, severity of mucosal damage, and gene expression of IL-1beta, CXCL1, and MPO activity, while IL-10 gene expression and cNOS activity were increased. Trinitrobenzenesulfonic Acid 56-60 interleukin 1 beta Rattus norvegicus 171-179 24028150-13 2014 CONCLUSION: These results showed the inhibitory effects of emodin on ATP-induced [Ca2+](c) increase, IL-1beta release, ROS production and phagocytosis attenuation in rat peritoneal macrophages, by inhibiting the activation of P2X7R. Adenosine Triphosphate 69-72 interleukin 1 beta Rattus norvegicus 101-109 24373431-8 2013 RESULTS: We found that treatment with tamoxifen markedly inhibited the protein expressions of TLR4, NF-kappaB and the downstream inflammatory agents, such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and intercellular adhesion molecule-1 (ICAM-1). Tamoxifen 38-47 interleukin 1 beta Rattus norvegicus 158-175 24801881-9 2014 The levels of interleukin-1beta and tumor necrosis factor-alpha decreased in the Gln group. Glutamine 81-84 interleukin 1 beta Rattus norvegicus 14-63 24848171-14 2014 CONCLUSION: The present study focused on both B and T cell mediated immunity and confirmed the beneficial effect of atorvastatin with decreased expressions of IL-1beta and IL-6. Atorvastatin 116-128 interleukin 1 beta Rattus norvegicus 159-167 25226844-8 2014 The group receiving hesperidin alone showed decreases in lipid peroxidation, NF-kappaB, TGF-beta, CTGF and IL-1beta and an increase in IL-10. Hesperidin 20-30 interleukin 1 beta Rattus norvegicus 107-115 24373431-8 2013 RESULTS: We found that treatment with tamoxifen markedly inhibited the protein expressions of TLR4, NF-kappaB and the downstream inflammatory agents, such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and intercellular adhesion molecule-1 (ICAM-1). Tamoxifen 38-47 interleukin 1 beta Rattus norvegicus 177-185 24314273-0 2013 L-arginine abolishes the hypothalamic serotonergic activation induced by central interleukin-1beta administration to normal rats. Arginine 0-10 interleukin 1 beta Rattus norvegicus 81-98 24359406-11 2013 Kolaviron prevented diabetes induced increase in the hepatic levels of proinflammatory cytokines; interleukin (IL)-1beta, IL-6, tumour necrosis factor (TNF-alpha) and monocyte chemotactic protein (MCP-1). kolaviron 0-9 interleukin 1 beta Rattus norvegicus 98-120 24076348-5 2013 The present study was designed to examine whether the inflammasome caspase-1 IL-1beta platform is involved in chronic constriction injury (CCI)-induced neuropathic pain and in lipoxin-induced analgesia. Lipoxins 176-183 interleukin 1 beta Rattus norvegicus 77-85 24455299-17 2013 Simvastatin significantly counteracted the increase in myocardium level of TNF- alpha , IL-1B, IL-6, MCP-1 and MIP-1 alpha , plasma cTnI, and apoptosis (P < 0.05). Simvastatin 0-11 interleukin 1 beta Rattus norvegicus 88-93 24134913-6 2013 Fructose feeding induced hyperlipidemia, and activated SphK1/S1P signaling pathway characterized by the elevation of SphK1 activity, S1P production as well as SphK1, S1PR1 and S1PR3 protein levels, which in turn caused NF-kappaB signaling activation to produce IL-1beta, IL-6 and TNF-alpha and inflammation in the liver of rats. Fructose 0-8 interleukin 1 beta Rattus norvegicus 261-269 24314273-2 2013 In the complex interplay involved in feeding modulation, nitric oxide has been ascribed a stimulatory action, which could be of significance in counteracting IL-1beta effects.The present study aims to explore the participation of the nitric oxide and the serotonin systems on the central mechanisms induced by IL-1beta and the relevance of their putative interactions to IL-1beta hypophagia in normal rats.Serotonin levels were determined in microdialysates of the ventromedial hypothalamus after a single intracerebroventricular injection of 10 ng of IL-1beta , with or without the pre-injection of 20 mug of the nitric oxide precursor L-arginine. Nitric Oxide 57-69 interleukin 1 beta Rattus norvegicus 310-318 24314273-2 2013 In the complex interplay involved in feeding modulation, nitric oxide has been ascribed a stimulatory action, which could be of significance in counteracting IL-1beta effects.The present study aims to explore the participation of the nitric oxide and the serotonin systems on the central mechanisms induced by IL-1beta and the relevance of their putative interactions to IL-1beta hypophagia in normal rats.Serotonin levels were determined in microdialysates of the ventromedial hypothalamus after a single intracerebroventricular injection of 10 ng of IL-1beta , with or without the pre-injection of 20 mug of the nitric oxide precursor L-arginine. Nitric Oxide 57-69 interleukin 1 beta Rattus norvegicus 310-318 24314273-1 2013 IL-1beta-induced anorexia may depend on interactions of the cytokine with neuropeptides and neurotransmitters of the central nervous system control of energy balance and serotonin is likely to be one catabolic mediator targeted by IL-1beta. Serotonin 170-179 interleukin 1 beta Rattus norvegicus 0-8 24314273-3 2013 IL-1beta significantly stimulated hypothalamic serotonin extracellular levels, with a peak variation of 130 +- 37% above baseline. Serotonin 47-56 interleukin 1 beta Rattus norvegicus 0-8 24314273-5 2013 The IL-1beta-induced serotonergic activation was abolished by the pre-injection of L-arginine while the hypophagic effect was unaffected.The data showed that one central effect of IL-1beta is serotonergic stimulation in the ventromedial hypothalamus, an action inhibited by nitric oxide activity. Arginine 83-93 interleukin 1 beta Rattus norvegicus 4-12 24314273-1 2013 IL-1beta-induced anorexia may depend on interactions of the cytokine with neuropeptides and neurotransmitters of the central nervous system control of energy balance and serotonin is likely to be one catabolic mediator targeted by IL-1beta. Serotonin 170-179 interleukin 1 beta Rattus norvegicus 231-239 24314273-5 2013 The IL-1beta-induced serotonergic activation was abolished by the pre-injection of L-arginine while the hypophagic effect was unaffected.The data showed that one central effect of IL-1beta is serotonergic stimulation in the ventromedial hypothalamus, an action inhibited by nitric oxide activity. Arginine 83-93 interleukin 1 beta Rattus norvegicus 180-188 24314273-5 2013 The IL-1beta-induced serotonergic activation was abolished by the pre-injection of L-arginine while the hypophagic effect was unaffected.The data showed that one central effect of IL-1beta is serotonergic stimulation in the ventromedial hypothalamus, an action inhibited by nitric oxide activity. Nitric Oxide 274-286 interleukin 1 beta Rattus norvegicus 4-12 24314273-2 2013 In the complex interplay involved in feeding modulation, nitric oxide has been ascribed a stimulatory action, which could be of significance in counteracting IL-1beta effects.The present study aims to explore the participation of the nitric oxide and the serotonin systems on the central mechanisms induced by IL-1beta and the relevance of their putative interactions to IL-1beta hypophagia in normal rats.Serotonin levels were determined in microdialysates of the ventromedial hypothalamus after a single intracerebroventricular injection of 10 ng of IL-1beta , with or without the pre-injection of 20 mug of the nitric oxide precursor L-arginine. Nitric Oxide 57-69 interleukin 1 beta Rattus norvegicus 158-166 24314273-5 2013 The IL-1beta-induced serotonergic activation was abolished by the pre-injection of L-arginine while the hypophagic effect was unaffected.The data showed that one central effect of IL-1beta is serotonergic stimulation in the ventromedial hypothalamus, an action inhibited by nitric oxide activity. Nitric Oxide 274-286 interleukin 1 beta Rattus norvegicus 180-188 23400915-9 2013 In rat brain microglia, BP significantly inhibited the lipopolysaccharide (LPS)-induced production of nitric oxide (NO), tumour necrosis factor-alpha and interleukin-1beta. butylidenephthalide 24-26 interleukin 1 beta Rattus norvegicus 154-171 25206641-5 2013 Results showed that puerarin pretreatment (intravenous injection) reduced the ischemic infarct volume, improved neurological deficit after cerebral ischemia/reperfusion and decreased the levels of interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha in brain tissue. puerarin 20-28 interleukin 1 beta Rattus norvegicus 197-214 24309933-9 2013 In addition, silencing of KSGal6ST attenuated KS expression on the primary cultured microglia and upregulated expression of some activation markers (TNF-alpha, IL-1beta, and iNOS) under the stimulation with lipopolysaccharide and IFN-gamma. Keratan Sulfate 26-28 interleukin 1 beta Rattus norvegicus 160-168 23872719-3 2013 CCI caused significant increase in tumor necrosis factor-alpha, interleukin 1 beta, prostaglandin E2, along with matrix metalloproteases (MMP-2) and nerve growth factor (NGF) levels in sciatic nerve and spinal cord concomitant with mechanical and thermal hyperalgesia, which were significantly reduced by oral administration of atorvastatin for 14 days as compared to CCI rats. CCI 0-3 interleukin 1 beta Rattus norvegicus 64-82 24083665-3 2013 We investigated whether bupivacaine exerts an influence on the Ca(2+) signaling and interleukin-1beta (IL-1beta) secretion in inflammation-reactive astrocytes when used at ultralow concentrations, < 10(-8) m. Furthermore, we wanted to determine if bupivacaine interacts with the opioid-, 5-hydroxytryptamine- (5-HT) and glutamate-receptor systems. Bupivacaine 24-35 interleukin 1 beta Rattus norvegicus 84-101 24083665-6 2013 Ultralow concentrations of bupivacaine attenuated the inflammation-induced upregulation of IL-1beta secretion. Bupivacaine 27-38 interleukin 1 beta Rattus norvegicus 91-99 24083665-7 2013 The results indicate that bupivacaine interacts with the opioid-, 5-HT- and glutamate-receptor systems by affecting Ca(2+) signaling and IL-1beta release in inflammation-reactive astrocytes. Bupivacaine 26-37 interleukin 1 beta Rattus norvegicus 137-145 23892052-5 2013 Indomethacin, time dependently stimulated the expression of proinflammatory molecules such as intercellular adhesion molecule 1(ICAM-1), vascular cell adhesion molecule 1(VCAM-1), interleukin1beta (IL-1beta), and monocyte chemotactic protein-1 (MCP-1) in gastric mucosa in parallel with the increase of neutrophil infiltration and injury of gastric mucosa in rat. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 180-196 23892052-5 2013 Indomethacin, time dependently stimulated the expression of proinflammatory molecules such as intercellular adhesion molecule 1(ICAM-1), vascular cell adhesion molecule 1(VCAM-1), interleukin1beta (IL-1beta), and monocyte chemotactic protein-1 (MCP-1) in gastric mucosa in parallel with the increase of neutrophil infiltration and injury of gastric mucosa in rat. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 198-206 23892052-7 2013 The prevention of MOS by antioxidant tryptamine-gallic acid hybrid (SEGA) inhibited indomethacin-induced expression of ICAM-1, VCAM-1, IL-1beta, and MCP-1. tryptamine 37-47 interleukin 1 beta Rattus norvegicus 135-143 23892052-7 2013 The prevention of MOS by antioxidant tryptamine-gallic acid hybrid (SEGA) inhibited indomethacin-induced expression of ICAM-1, VCAM-1, IL-1beta, and MCP-1. Gallic Acid 48-59 interleukin 1 beta Rattus norvegicus 135-143 23892052-7 2013 The prevention of MOS by antioxidant tryptamine-gallic acid hybrid (SEGA) inhibited indomethacin-induced expression of ICAM-1, VCAM-1, IL-1beta, and MCP-1. Indomethacin 84-96 interleukin 1 beta Rattus norvegicus 135-143 23690274-8 2013 The mechanisms by which unfractionated heparin exerts its anti-inflammatory effect are correlated with inhibition of IL-1beta and IL-6 production via inactivation of NF-kappaB. Heparin 39-46 interleukin 1 beta Rattus norvegicus 117-125 24444809-5 2013 Concentrations of proinflammatory cytokines like IL-1 beta, TNF alpha and IL-6 were significantly higher in arthritic rats which were reduced on treatment with alginic acid. Alginic Acid 160-172 interleukin 1 beta Rattus norvegicus 49-58 24455774-0 2013 Scopoletin suppresses IL-6 production from fibroblast-like synoviocytes of adjuvant arthritis rats induced by IL-1beta stimulation. Scopoletin 0-10 interleukin 1 beta Rattus norvegicus 112-120 24570834-8 2013 IL-1beta and IL-6 decreased and increased in parkinsonian rats and in 8-OH-DPAT-treated parkinsonian rats, respectively. 8-Hydroxy-2-(di-n-propylamino)tetralin 70-79 interleukin 1 beta Rattus norvegicus 0-8 23794035-5 2013 Increasing doses of sivelestat inhibits the expression of lipase, amylase, corticosterone, IL-1beta, TNF-alpha, and nuclear factor-kappaB. sivelestat 20-30 interleukin 1 beta Rattus norvegicus 91-99 28664069-11 2013 Regarding TNF-alpha pro-inflammatory cytokine, there was no particular trend; however, the expression of IL-1beta mRNA increased in the white muscle of the gastrocnemius muscle and tibialis anterior muscle after sciatic nerve cut, but showed a decrease with exercise and CLA treatment. Linoleic Acids, Conjugated 271-274 interleukin 1 beta Rattus norvegicus 105-113 23957729-5 2013 The serum levels of TNF-alpha, IL-6, and IL-1beta were found to have decreased as a result of the administration of both doses of levosimendan in the IR. Simendan 130-142 interleukin 1 beta Rattus norvegicus 41-49 24120988-2 2013 We focused on whether naloxone, ouabain, and bupivacaine, all agents with reported anti-inflammatory effects on astrocytes, could affect the release of TNF-alpha and IL-1beta in microglia. Naloxone 22-30 interleukin 1 beta Rattus norvegicus 166-174 24312352-3 2013 The aim of this study was to investigate the impact of wortmannin, a PI3K/Akt inhibitor, on SAP rats through exposure to sodium taurocholate (STC) after 3 h and 6 h. The SAP group was found to have a significant increase in pancreas Akt expression, along with the activation of serum amylase, TNF-alpha, IL-1beta, and IL-6, and pancreas histological aggravation. Wortmannin 55-65 interleukin 1 beta Rattus norvegicus 304-312 23973554-5 2013 TCI increased the expression of TLR4 and the EphB1 receptor, the activation of astrocytes and microglial cells, and increased levels of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha). tci 0-3 interleukin 1 beta Rattus norvegicus 136-153 23973554-5 2013 TCI increased the expression of TLR4 and the EphB1 receptor, the activation of astrocytes and microglial cells, and increased levels of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha). tci 0-3 interleukin 1 beta Rattus norvegicus 155-163 23973554-8 2013 The TCI-induced activation of astrocytes and microglial cells, as well as the increased levels of IL-1beta and TNF-alpha, were inhibited by intrathecal administration of TLR4-targeting siRNA2 and the EphB receptor antagonist EphB2-Fc, respectively. tci 4-7 interleukin 1 beta Rattus norvegicus 98-106 24206061-5 2013 The mRNA levels of IL-1beta were significantly reduced in GK rats given 0.1% EGCG (0.059 +- 0.008; means +- SEM in arbitrary unit) compared with those in GK rats given a control diet (0.135 +- 0.011), but not in those given 0.2% EGCG (0.123 +- 0.012) or 0.5% EGCG (0.112 +- 0.019). epigallocatechin gallate 77-81 interleukin 1 beta Rattus norvegicus 19-27 24206061-5 2013 The mRNA levels of IL-1beta were significantly reduced in GK rats given 0.1% EGCG (0.059 +- 0.008; means +- SEM in arbitrary unit) compared with those in GK rats given a control diet (0.135 +- 0.011), but not in those given 0.2% EGCG (0.123 +- 0.012) or 0.5% EGCG (0.112 +- 0.019). epigallocatechin gallate 229-233 interleukin 1 beta Rattus norvegicus 19-27 24206061-5 2013 The mRNA levels of IL-1beta were significantly reduced in GK rats given 0.1% EGCG (0.059 +- 0.008; means +- SEM in arbitrary unit) compared with those in GK rats given a control diet (0.135 +- 0.011), but not in those given 0.2% EGCG (0.123 +- 0.012) or 0.5% EGCG (0.112 +- 0.019). epigallocatechin gallate 229-233 interleukin 1 beta Rattus norvegicus 19-27 24120988-2 2013 We focused on whether naloxone, ouabain, and bupivacaine, all agents with reported anti-inflammatory effects on astrocytes, could affect the release of TNF-alpha and IL-1beta in microglia. Ouabain 32-39 interleukin 1 beta Rattus norvegicus 166-174 24120988-2 2013 We focused on whether naloxone, ouabain, and bupivacaine, all agents with reported anti-inflammatory effects on astrocytes, could affect the release of TNF-alpha and IL-1beta in microglia. Bupivacaine 45-56 interleukin 1 beta Rattus norvegicus 166-174 24177287-9 2013 The adjunction of berberine with verapamil improved the neurological outcome in a battery of behavioral paradigms, improved spatial memory in Morris water maze task, ameliorated the oxidative-nitrosative stress, increased acetylcholinesterase (AChE) activity, as well as improved mitochondrial complex (I, II, and IV) activity, reducing tumor necrosis factor-alpha, interleukin-1 beta and caspase-3 levels in brain tissues as compared to berberine alone group in ischemic rats. Berberine 18-27 interleukin 1 beta Rattus norvegicus 366-384 23928073-6 2013 Preventing ERK1/2 activation with 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthiol]-butadiene antagonized IL-1beta-induced GFAP expression while inhibiting selectively nuclear translocation of NF-kB with caffeic-acid phenethyl-ester down-regulated both ERK1/2 and GFAP expression induced by IL-1beta. 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthiol]-butadiene 34-95 interleukin 1 beta Rattus norvegicus 108-116 24260182-6 2013 Hemin administration to ZDFs abated hepatic/plasma triglycerides and cholesterol, and suppressed several pro-inflammatory cytokines and chemokines including, TNF-alpha, IL-6, IL-1beta, macrophage-inflammatory-protein-1alpha (MIP-1alpha) and macrophage-chemoattractant-protein-1 (MCP-1), with corresponding reduction of the pro-inflammatory M1-phenotype marker, ED1 and hepatic macrophage infiltration. zdfs 24-28 interleukin 1 beta Rattus norvegicus 175-183 23928073-6 2013 Preventing ERK1/2 activation with 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthiol]-butadiene antagonized IL-1beta-induced GFAP expression while inhibiting selectively nuclear translocation of NF-kB with caffeic-acid phenethyl-ester down-regulated both ERK1/2 and GFAP expression induced by IL-1beta. caffeic acid phenethyl ester 206-234 interleukin 1 beta Rattus norvegicus 108-116 24055021-5 2013 Furthermore, our results showed that PA-MSHA effectively increased serum pro-inflammatory mediators (TNF-alpha, IL-1beta and IL-6) at the early stage (8 days) but increased anti-inflammatory mediators (IL-4 and IL-10) at the late stage (16 days). pa-msha 37-44 interleukin 1 beta Rattus norvegicus 112-120 23892126-6 2013 Also, ultrafine PM activated NF-kappaB and increased IL-1beta and TNFalpha in the striatum. ultrafine 6-15 interleukin 1 beta Rattus norvegicus 53-61 24007200-7 2013 Treatment with melatonin markedly decreased the expressions of TLR4 pathway-related agents, such as high-mobility group box 1 (HMGB1), TLR4, nuclear factor-kappaB (NF-kappaB), myeloid differentiation factor 88 (MyD88), interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and inducible nitric oxide synthase (iNOS). Melatonin 15-24 interleukin 1 beta Rattus norvegicus 219-236 24007200-7 2013 Treatment with melatonin markedly decreased the expressions of TLR4 pathway-related agents, such as high-mobility group box 1 (HMGB1), TLR4, nuclear factor-kappaB (NF-kappaB), myeloid differentiation factor 88 (MyD88), interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and inducible nitric oxide synthase (iNOS). Melatonin 15-24 interleukin 1 beta Rattus norvegicus 238-246 23993832-9 2013 Systemic administration of pentoxifylline immediately after hypoxic-ischemic encephalopathy significantly reduced the tumor necrosis factor-alpha and interleukin-1beta messenger RNA expression levels in ischemic tissue as compared with the ischemia group. Pentoxifylline 27-41 interleukin 1 beta Rattus norvegicus 150-167 23993832-12 2013 CONCLUSIONS: Based on the significantly lower interleukin-1beta and tumor necrosis factor-alpha gene expression measured after 4 and 24 hours and significantly reduced caspase-3 activity measured colorimetrically in the animals treated with pentoxifylline, our findings suggest that pentoxifylline may reduce brain damage due to hypoxic-ischemic injury. Pentoxifylline 283-297 interleukin 1 beta Rattus norvegicus 46-95 24204851-12 2013 Furthermore, triptolide significantly reduced the expression of angiogenic activators including TNF-alpha, IL-17, VEGF, VEGFR, Ang-1, Ang-2 and Tie2, as well as suppressed the IL1-beta-induced phosphorylated of ERK, p38 and JNK at protein levels. triptolide 13-23 interleukin 1 beta Rattus norvegicus 176-184 23911880-10 2013 ALA administration increased BMD levels and decreased osteocalcin, osteopontin, IL-1 beta, IL-6, and TNF-alpha levels versus OVX and OVX+INF control groups. Thioctic Acid 0-3 interleukin 1 beta Rattus norvegicus 80-89 24152426-4 2013 RESULTS: Cytokines IL-1alpha and IL-1beta were reduced 2-fold (p<0.05) in DRG and/or nerve of 2 and 5 month streptozotocin (STZ)-diabetic rats. Streptozocin 111-125 interleukin 1 beta Rattus norvegicus 33-41 24152426-4 2013 RESULTS: Cytokines IL-1alpha and IL-1beta were reduced 2-fold (p<0.05) in DRG and/or nerve of 2 and 5 month streptozotocin (STZ)-diabetic rats. Streptozocin 127-130 interleukin 1 beta Rattus norvegicus 33-41 24152426-7 2013 STAT3 phosphorylation on Tyr705 or Ser727 was depressed in DRG from STZ-diabetic mice and treatment of cultures derived from STZ-diabetic rats with IL-1beta for 30 min raised phosphorylation of STAT3 on Tyr705 and Ser727 by 1.5 to 2-fold (p<0.05). Streptozocin 68-71 interleukin 1 beta Rattus norvegicus 148-156 24152426-7 2013 STAT3 phosphorylation on Tyr705 or Ser727 was depressed in DRG from STZ-diabetic mice and treatment of cultures derived from STZ-diabetic rats with IL-1beta for 30 min raised phosphorylation of STAT3 on Tyr705 and Ser727 by 1.5 to 2-fold (p<0.05). Streptozocin 125-128 interleukin 1 beta Rattus norvegicus 148-156 24003233-0 2013 Endogenous interleukin-1beta in neuropathic rats enhances glutamate release from the primary afferents in the spinal dorsal horn through coupling with presynaptic N-methyl-D-aspartic acid receptors. Glutamic Acid 58-67 interleukin 1 beta Rattus norvegicus 11-28 24003233-3 2013 We demonstrated that endogenous IL-1beta in neuropathic rats enhances glutamate release from the primary afferent terminals and non-NMDA glutamate receptor activities in postsynaptic neurons in the spinal dorsal horn. Glutamic Acid 70-79 interleukin 1 beta Rattus norvegicus 32-40 24003233-5 2013 Presynaptic NMDA receptors are effector receptors used by the endogenous IL-1beta to enhance glutamate release from the primary afferents in neuropathic rats. Glutamic Acid 93-102 interleukin 1 beta Rattus norvegicus 73-81 24003233-6 2013 This is further supported by the fact that NMDA currents recorded from small neurons in the dorsal root ganglion of normal rats are potentiated by exogenous IL-1beta. N-Methylaspartate 43-47 interleukin 1 beta Rattus norvegicus 157-165 24003233-8 2013 Hence, functional coupling between IL-1beta receptors and presynaptic NMDA receptors at the primary afferent terminals is a crucial mechanism leading to enhanced glutamate release and activation of non-NMDA receptors in the spinal dorsal horn neurons in neuropathic pain conditions. Glutamic Acid 162-171 interleukin 1 beta Rattus norvegicus 35-43 23541609-7 2013 Triptolide treatment markedly inhibited AC-induced increases in myocardial collagen volume fraction, collagen type I/III deposition, left ventricular end-diastolic pressure, expressions of pro-fibrogenic factors (transforming growth factor-beta and angiotensin II) and pro-inflammatory cytokines (IL-1beta and IL-6), NF-kappaB activation and inflammatory cell infiltration in left ventricles compared with vehicle, without affecting cardiac hypertrophy. triptolide 0-10 interleukin 1 beta Rattus norvegicus 297-305 24012928-0 2013 Levosimendan inhibits interleukin-1beta-induced cell migration and MMP-9 secretion in rat cardiac fibroblasts. Simendan 0-12 interleukin 1 beta Rattus norvegicus 22-39 24012928-3 2013 Therefore, we investigated the effects of levosimendan on interleukin (IL)-1beta-induced MMP-9 secretion and migration in adult rat cardiac fibroblasts. Simendan 42-54 interleukin 1 beta Rattus norvegicus 58-80 24012928-9 2013 Levosimendan (3-100 muM) concentration-dependently inhibited IL-1beta (4 ng/ml)-induced MMP-9 secretion, activity and mRNA expression. Simendan 0-12 interleukin 1 beta Rattus norvegicus 61-69 24012928-10 2013 Levosimendan inhibited IL-1beta (4 ng/ml)-induced ERK phosphorylation. Simendan 0-12 interleukin 1 beta Rattus norvegicus 23-31 24012928-11 2013 Levosimendan (10 and 100 muM) inhibited IL-1beta-induced migration, and CTTHWGFTLC peptide (10 muM), an MMP inhibitor, or PD98059 (50 muM), an ERK inhibitor, also suppressed it. Simendan 0-12 interleukin 1 beta Rattus norvegicus 40-48 24012928-12 2013 The present study for the first time demonstrated in adult rat cardiac fibroblasts that levosimendan inhibits IL-1beta-induced migration at least partly through the inhibition of MMP-9 secretion via suppressing ERK phosphorylation. Simendan 88-100 interleukin 1 beta Rattus norvegicus 110-118 23541609-7 2013 Triptolide treatment markedly inhibited AC-induced increases in myocardial collagen volume fraction, collagen type I/III deposition, left ventricular end-diastolic pressure, expressions of pro-fibrogenic factors (transforming growth factor-beta and angiotensin II) and pro-inflammatory cytokines (IL-1beta and IL-6), NF-kappaB activation and inflammatory cell infiltration in left ventricles compared with vehicle, without affecting cardiac hypertrophy. Charcoal 40-42 interleukin 1 beta Rattus norvegicus 297-305 23269651-8 2013 Sesamol also abrogated the non-enzymatic inflammatory markers (TNF, IL-1beta, IL-6, COX-2, PGE2, ROS, and H2O2,) effectively. sesamol 0-7 interleukin 1 beta Rattus norvegicus 68-76 23889535-4 2013 Target engagement of JNJ-47965567 was demonstrated by ex vivo receptor binding autoradiography and in vivo blockade of Bz-ATP induced IL-1beta release in the rat brain. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 119-125 interleukin 1 beta Rattus norvegicus 134-142 23889535-8 2013 JNJ-47965567 exhibited target engagement in rat brain, with a brain EC50 of 78 +- 19 ng mL(-1) (P2X7 receptor autoradiography) and functional block of Bz-ATP induced IL-1beta release. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 151-157 interleukin 1 beta Rattus norvegicus 166-174 24779037-9 2013 Furthermore, melatonin pre-treatment reduced pro-inflammatory cytokines IL-1b and TNF-a and increased the serum levels of anti-inflammatory cytokine IL-4. Melatonin 13-22 interleukin 1 beta Rattus norvegicus 72-77 23277230-13 2013 Fisetin treatment showed a significant decline in the levels of blood glucose, glycosylated hemoglobin (HbA1c), NF-kB p65 unit (in pancreas) and IL-1beta (plasma), serum nitric oxide (NO) with an elevation in plasma insulin. fisetin 0-7 interleukin 1 beta Rattus norvegicus 145-153 23299178-9 2013 Our data also revealed a significant reduction in the activity of apoptosis using terminal dUTP nick end-labeling and reduced expression of TGF-beta1 and IL-1beta in the pancreatic beta-cell of ferulic acid-treated rats. ferulic acid 194-206 interleukin 1 beta Rattus norvegicus 154-162 23933652-8 2013 The pretreatment significantly reduced the levels of TNF-alpha, IL-1beta and MDA, increased SOD activity in the peripheral blood of PQ-treated rats. Paraquat 132-134 interleukin 1 beta Rattus norvegicus 64-72 23963446-8 2013 RESULTS: MTX increased the mRNA levels of TNF-alpha, IL-1beta, MIP-2, and TLR4 in the small intestine, as well as the protein expression of claudin-2. Methotrexate 9-12 interleukin 1 beta Rattus norvegicus 53-61 23816751-2 2013 Cytotoxic events following SAH, such as extracellular accumulation of adenosine triphosphate (ATP), may activate the P2X purinoceptor 7 (P2X7R)/cryopyrin inflammasome axis, thus inducing the proinflammatory cytokine IL-1beta/IL-18 secretion. Adenosine Triphosphate 70-92 interleukin 1 beta Rattus norvegicus 216-224 23816751-2 2013 Cytotoxic events following SAH, such as extracellular accumulation of adenosine triphosphate (ATP), may activate the P2X purinoceptor 7 (P2X7R)/cryopyrin inflammasome axis, thus inducing the proinflammatory cytokine IL-1beta/IL-18 secretion. Adenosine Triphosphate 94-97 interleukin 1 beta Rattus norvegicus 216-224 23775504-0 2013 Olmesartan decreases IL-1beta and TNF-alpha levels; downregulates MMP-2, MMP-9, COX-2, and RANKL; and upregulates OPG in experimental periodontitis. olmesartan 0-10 interleukin 1 beta Rattus norvegicus 21-29 23816751-11 2013 In LPS-primed naive rats, BzATP induced caspase-1 activation and mature IL-1beta release were neutralized by cryopyrin siRNA. BzATP 26-31 interleukin 1 beta Rattus norvegicus 72-80 23775504-6 2013 In addition, the group that was treated with 6 mg/kg olmesartan showed a decreased level of IL-1beta (p < 0.05), and all doses of olmesartan resulted in decreased levels of TNF-alpha. olmesartan 53-63 interleukin 1 beta Rattus norvegicus 92-100 23867467-2 2013 Formalin-induced responses were evaluated 24h after an IL-1beta injection. Formaldehyde 0-8 interleukin 1 beta Rattus norvegicus 55-63 23948071-11 2013 Chronic administration of haloperidol also induced oxidative damage and neuroinflammation (TNF-alpha and IL-1beta) in brain regions. Haloperidol 26-37 interleukin 1 beta Rattus norvegicus 105-113 23850171-3 2013 As, pro-inflammatory mediators and nitric oxide control the expression of Hsps, our aim was to investigate the effect of Abeta(25-35) on the concentration of IL-1beta, TNF-alpha and nitrite levels, and their relation to pHSF-1, Hsp-60, -70 and -90 expressions, in the rat C6 astrocyte cells. UNII-042A8N37WH 121-126 interleukin 1 beta Rattus norvegicus 158-166 23652767-0 2013 N-acetyl-Ser-Asp-Lys-Pro inhibits interleukin-1beta-mediated matrix metalloproteinase activation in cardiac fibroblasts. goralatide 0-24 interleukin 1 beta Rattus norvegicus 34-51 24146541-9 2013 The messenger ribonucleic acid expression of the P2X7 receptor, TNF-alpha, IL-1beta, and IL-6 was significantly upregulated in the retina after IOP elevation, and was suppressed by treatment with OxATP. oxatp 196-201 interleukin 1 beta Rattus norvegicus 75-83 23867467-3 2013 A subcutaneous injection of 10ng of IL-1beta elevated the formalin-induced scratching response significantly in the second phase compared to the vehicle-treated group. Formaldehyde 58-66 interleukin 1 beta Rattus norvegicus 36-44 23867467-5 2013 Pretreatment with IL-1beta increased the p-ERK and p-p38 expression induced by the formalin injection. Formaldehyde 83-91 interleukin 1 beta Rattus norvegicus 18-26 23867467-7 2013 The intracisternal administration of minocycline (50mug), a microglia inhibitor, attenuated the increased formalin-induced scratching responses in the IL-1beta-treated rats. Minocycline 37-48 interleukin 1 beta Rattus norvegicus 151-159 23867467-7 2013 The intracisternal administration of minocycline (50mug), a microglia inhibitor, attenuated the increased formalin-induced scratching responses in the IL-1beta-treated rats. Formaldehyde 106-114 interleukin 1 beta Rattus norvegicus 151-159 23867467-8 2013 The intracisternal administration of PD98059 (1, 10mug), a MEK inhibitor, and SB203580 (1, 5mug), a p38 inhibitor, also attenuated the number of formalin-induced scratches in the second phase in the IL-1beta-treated rats. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 37-44 interleukin 1 beta Rattus norvegicus 199-207 23867467-8 2013 The intracisternal administration of PD98059 (1, 10mug), a MEK inhibitor, and SB203580 (1, 5mug), a p38 inhibitor, also attenuated the number of formalin-induced scratches in the second phase in the IL-1beta-treated rats. SB 203580 78-86 interleukin 1 beta Rattus norvegicus 199-207 23867467-8 2013 The intracisternal administration of PD98059 (1, 10mug), a MEK inhibitor, and SB203580 (1, 5mug), a p38 inhibitor, also attenuated the number of formalin-induced scratches in the second phase in the IL-1beta-treated rats. Formaldehyde 145-153 interleukin 1 beta Rattus norvegicus 199-207 24167735-9 2013 Both MK-886 and DITPA significantly counteract the increase in the levels of cardiac TNF- alpha , IL-1 beta , and ICAM-1 and plasma level of cTnI (P < 0.05). MK-886 5-11 interleukin 1 beta Rattus norvegicus 98-107 24167735-9 2013 Both MK-886 and DITPA significantly counteract the increase in the levels of cardiac TNF- alpha , IL-1 beta , and ICAM-1 and plasma level of cTnI (P < 0.05). 3,5-diiodothyropropionic acid 16-21 interleukin 1 beta Rattus norvegicus 98-107 24007297-9 2013 An increased IL-1beta response in neocortical and basal gray neurons was demonstrated at 4 h after LPS + HI-exposure and preceded other neuroinflammatory responses such as microglial and astroglial cell activation. hi 105-107 interleukin 1 beta Rattus norvegicus 13-21 23933318-0 2013 Activation of the canonical nuclear factor-kappaB pathway is involved in isoflurane-induced hippocampal interleukin-1beta elevation and the resultant cognitive deficits in aged rats. Isoflurane 73-83 interleukin 1 beta Rattus norvegicus 104-121 23933318-4 2013 These events were accompanied by an increase in NF-kappaB p65 nuclear translocation at 6h after isoflurane exposure and hippocampal IL-1beta elevation from 1 to 6h after isoflurane exposure. Isoflurane 170-180 interleukin 1 beta Rattus norvegicus 132-140 23933318-6 2013 Pharmacological inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate markedly suppressed the IL-1beta increase and NF-kappaB signaling, and also mitigated the severity of cognitive deficits in the Morris water maze task. pyrrolidine dithiocarbamic acid 54-81 interleukin 1 beta Rattus norvegicus 106-114 23933318-7 2013 Overall, our results demonstrate that isoflurane-induced cognitive deficits may stem from upregulation of hippocampal IL-1beta, partially via activation of the canonical NF-kappaB pathway, in aged rats. Isoflurane 38-48 interleukin 1 beta Rattus norvegicus 118-126 24007297-13 2013 Neuronal cells were the first cells to produce IL-1beta in LPS + HI-exposed full-term brains. hi 65-67 interleukin 1 beta Rattus norvegicus 47-55 24007297-14 2013 Such IL-1beta production might be responsible for neuronal self-injuries via well-described neurotoxic mechanisms such as IL-1beta-induced nitric oxide production, or IL-1beta-dependent exacerbation of excitotoxic damage. Nitric Oxide 139-151 interleukin 1 beta Rattus norvegicus 5-13 24007297-14 2013 Such IL-1beta production might be responsible for neuronal self-injuries via well-described neurotoxic mechanisms such as IL-1beta-induced nitric oxide production, or IL-1beta-dependent exacerbation of excitotoxic damage. Nitric Oxide 139-151 interleukin 1 beta Rattus norvegicus 122-130 24007297-14 2013 Such IL-1beta production might be responsible for neuronal self-injuries via well-described neurotoxic mechanisms such as IL-1beta-induced nitric oxide production, or IL-1beta-dependent exacerbation of excitotoxic damage. Nitric Oxide 139-151 interleukin 1 beta Rattus norvegicus 122-130 23322373-8 2013 Blood levels of inflammation-related high-sensitivity C-reactive protein and cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha were increased after exposure to three silica nanoparticles at 10 mg/Kg bw. Silicon Dioxide 218-224 interleukin 1 beta Rattus norvegicus 95-112 24007266-8 2013 Meanwhile, the expression levels of proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta) and IL-6, were found to be upregulated, which may have played an import role in neuronal damage mediated by the nSMase2/ceramide pathway. Ceramides 263-271 interleukin 1 beta Rattus norvegicus 114-131 24007266-8 2013 Meanwhile, the expression levels of proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta) and IL-6, were found to be upregulated, which may have played an import role in neuronal damage mediated by the nSMase2/ceramide pathway. Ceramides 263-271 interleukin 1 beta Rattus norvegicus 133-141 23322373-9 2013 Moreover, the levels of IL-1beta and IL-6 at 10 mg/Kg bw of silica nanoparticles (30 nm) were higher than the fine silica particles. Silicon Dioxide 60-66 interleukin 1 beta Rattus norvegicus 24-32 23808809-2 2013 The aim of the present investigation was to evaluate the effect of noradrenaline (NA) on the release of IL-1beta, IL-6 and TNFalpha by macrophages from ObZ, as well as the effect of habitual exercise (running, 5days/week for 35 min at 35cm/s for 14week); all of them using lean Zucker rats (Fa/fa) (LZ) as reference values. Norepinephrine 67-80 interleukin 1 beta Rattus norvegicus 104-112 23774260-10 2013 Consistently, TNF-alpha, IL-1beta and IL-6 expression, representative NF-kappaB target genes, were almost completely prohibited by isorhamnetin. 3-methylquercetin 131-143 interleukin 1 beta Rattus norvegicus 25-33 23707774-8 2013 Furthermore, fluoride also induced testicular inflammation, as manifested by gene up-regulation of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in a nuclear factor-kappaB (NF-kappaB)-dependent manner. Fluorides 13-21 interleukin 1 beta Rattus norvegicus 140-157 23352192-10 2013 RESULTS: LPS-induced IL-1beta and TNF-alpha protein expression was significantly lower in the spleen of the morphine-tolerant animals than in the placebo-control animals. Morphine 108-116 interleukin 1 beta Rattus norvegicus 21-29 23726524-7 2013 The blood of MMA-treated animals showed a decrease in the number of polymorphonuclear and neutrophils, and an increase in mononuclear and other cell types, as well as an increase of IL-1beta and TNF-alpha levels. Methylmalonic Acid 13-16 interleukin 1 beta Rattus norvegicus 182-190 23775412-5 2013 The expression of PAR4 in cultured DRG neurons was also assessed after treatment with IL-1beta with pre-addition of phorbol-12-myristate 13-acetate (PMA, a PKC activator) or chelerythrine chloride (a PKC inhibitor). Tetradecanoylphorbol Acetate 116-147 interleukin 1 beta Rattus norvegicus 86-94 23775412-8 2013 This IL-1beta effect was enhanced in DRG neurons when DRG cultures were pre-treatment with the PMA. Tetradecanoylphorbol Acetate 95-98 interleukin 1 beta Rattus norvegicus 5-13 23775412-9 2013 But pre-incubation with chelerythrine chloride strongly inhibited the IL-1beta-induced increase of PAR4 mRNA and protein levels. chelerythrine 24-46 interleukin 1 beta Rattus norvegicus 70-78 23707774-8 2013 Furthermore, fluoride also induced testicular inflammation, as manifested by gene up-regulation of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in a nuclear factor-kappaB (NF-kappaB)-dependent manner. Fluorides 13-21 interleukin 1 beta Rattus norvegicus 159-167 23583655-4 2013 Ethanol-exposed rats showed impaired spatial navigation in the Morris water maze test and poor retention in the elevated plus maze task which was coupled with enhanced acetylcholinesterase activity, increased oxidative-nitrosative stress, cytokines (tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta)), NF-kbeta and caspase-3 levels in different brain regions (cerebral cortex and hippocampus) of ethanol-treated rats. Ethanol 0-7 interleukin 1 beta Rattus norvegicus 294-312 23850644-6 2013 Inductions of proinflammatory markers (TNF-alpha, IL-1beta, iNOS, and COX-2) were also suppressed by OBA-09 in both the LPS and MCAO models. OBA-09 101-107 interleukin 1 beta Rattus norvegicus 50-58 24009718-11 2013 Real-time RT-PCR demonstrated IL-1beta up-expression in the ipsilateral spinal dorsal horn after the lesion, which was significantly decreased by tramadol and propentofylline coadministration. Tramadol 146-154 interleukin 1 beta Rattus norvegicus 30-38 24009718-11 2013 Real-time RT-PCR demonstrated IL-1beta up-expression in the ipsilateral spinal dorsal horn after the lesion, which was significantly decreased by tramadol and propentofylline coadministration. propentofylline 159-174 interleukin 1 beta Rattus norvegicus 30-38 24009718-12 2013 Inhibiting proinflammatory factor IL-1beta contributed to the synergistic effects of tramadol and propentofylline coadministration on rat peripheral nerve injury-induced neuropathic pain. Tramadol 85-93 interleukin 1 beta Rattus norvegicus 34-42 24009718-12 2013 Inhibiting proinflammatory factor IL-1beta contributed to the synergistic effects of tramadol and propentofylline coadministration on rat peripheral nerve injury-induced neuropathic pain. propentofylline 98-113 interleukin 1 beta Rattus norvegicus 34-42 23583655-4 2013 Ethanol-exposed rats showed impaired spatial navigation in the Morris water maze test and poor retention in the elevated plus maze task which was coupled with enhanced acetylcholinesterase activity, increased oxidative-nitrosative stress, cytokines (tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta)), NF-kbeta and caspase-3 levels in different brain regions (cerebral cortex and hippocampus) of ethanol-treated rats. Ethanol 0-7 interleukin 1 beta Rattus norvegicus 314-322 23904373-6 2013 Real-time PCR analysis demonstrated that isoflurane anesthesia increased mRNA levels of TNF-alpha, IL-1beta and IL-6, which was consistent with the ELISA results. Isoflurane 41-51 interleukin 1 beta Rattus norvegicus 99-107 23710625-5 2013 In the syngeneic Lewis-to-Lewis rat model of kidney transplantation, xenon exposure to donors before graft retrieval or to recipients after engraftment decreased caspase-3 expression, localized HMGB-1 within nuclei and prevented TLR-4/NF-kappaB activation in tubular cells; serum pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha were reduced and renal function was preserved. Xenon 69-74 interleukin 1 beta Rattus norvegicus 307-315 23940786-9 2013 ETs inhibited IL-8 secretion induced by TNF-alpha and IL-1beta at low concentrations (IC50 range of 0.7-4 microg/mL). ets 0-3 interleukin 1 beta Rattus norvegicus 54-62 23766263-4 2013 APPROACH AND RESULTS: Sprague Dawley rats subjected to retinopathy induced by hyperoxia (80% O2; O2-induced retinopathy) exhibited retinal vaso-obliteration associated with microglial activation, NLRP3 upregulation, and IL-1beta and Sema3A release; IL-1beta was mostly generated by microglia. Oxygen 97-99 interleukin 1 beta Rattus norvegicus 220-228 23766263-4 2013 APPROACH AND RESULTS: Sprague Dawley rats subjected to retinopathy induced by hyperoxia (80% O2; O2-induced retinopathy) exhibited retinal vaso-obliteration associated with microglial activation, NLRP3 upregulation, and IL-1beta and Sema3A release; IL-1beta was mostly generated by microglia. Oxygen 97-99 interleukin 1 beta Rattus norvegicus 249-257 23766263-8 2013 CONCLUSIONS: Our findings suggest that in the early stages of O2-induced retinopathy, retinal microglia are activated to produce IL-1beta, which sustains the activation of microglia and induces microvascular injury through the release of Sema3A from adjacent neurons. Oxygen 62-64 interleukin 1 beta Rattus norvegicus 129-137 23500899-6 2013 In the rat bone milieu, high-methionine diet-induced hyperhomocysteinemia lowered FOXO1 and OPG expression and increased synthesis of proresorptive and inflammatory cytokines such as RANKL, M-CSF, IL-1alpha, IL-1beta, G-CSF, GM-CSF, MIP-1alpha, IFN-gamma, IL-17, and TNF-alpha. Methionine 29-39 interleukin 1 beta Rattus norvegicus 208-216 23807148-4 2013 The results of our study demonstrated that the exposure of H9c2 cardiac cells to DOX reduced cell viability and stimulated an inflammatory response, as demonstrated by an increase in the levels of interleukin-1beta (IL-1beta) and IL-6, as well as tumor necrosis factor-alpha (TNF-alpha) production. Doxorubicin 81-84 interleukin 1 beta Rattus norvegicus 197-214 23480366-9 2013 Upregulation of IL-1beta and TNF-alpha mRNAs and plasma IL-1beta and TNF-alpha levels were significantly attenuated by melatonin and L-tryptophan. Melatonin 119-128 interleukin 1 beta Rattus norvegicus 16-24 23480366-9 2013 Upregulation of IL-1beta and TNF-alpha mRNAs and plasma IL-1beta and TNF-alpha levels were significantly attenuated by melatonin and L-tryptophan. Melatonin 119-128 interleukin 1 beta Rattus norvegicus 56-64 23480366-9 2013 Upregulation of IL-1beta and TNF-alpha mRNAs and plasma IL-1beta and TNF-alpha levels were significantly attenuated by melatonin and L-tryptophan. Tryptophan 133-145 interleukin 1 beta Rattus norvegicus 16-24 23480366-9 2013 Upregulation of IL-1beta and TNF-alpha mRNAs and plasma IL-1beta and TNF-alpha levels were significantly attenuated by melatonin and L-tryptophan. Tryptophan 133-145 interleukin 1 beta Rattus norvegicus 56-64 23480366-10 2013 We conclude that melatonin protects against acid reflux-induced damage via activation of MT2 receptors mediated by NO and CGRP released from sensory nerves and the suppression of expression and release of TNF-alpha and IL-1beta. Melatonin 17-26 interleukin 1 beta Rattus norvegicus 219-227 23748101-16 2013 The expressional levels of apoptosis related genes (Bax, Bcl-2) and inflammation related genes (IL-1 beta, TNF alpha, MCP-1 and CCR2) were measured by real-time PCR, the results showed that minocycline treatment upregulated Bcl-2 expression and inhibits TNF alpha expression since early stage of BRVO. Minocycline 190-201 interleukin 1 beta Rattus norvegicus 96-105 23260460-10 2013 After transplantation, the carbon monoxide-ventilation group had better oxygenation; higher levels of tissue cyclic guanosine monophosphate, heme oxidase-1 expression, and p38 phosphorylation; reduced c-Jun N-terminal kinase phosphorylation; and reduced expression of interleukin-6 and interleukin-1beta messenger RNA. Carbon Monoxide 27-42 interleukin 1 beta Rattus norvegicus 286-303 23807148-4 2013 The results of our study demonstrated that the exposure of H9c2 cardiac cells to DOX reduced cell viability and stimulated an inflammatory response, as demonstrated by an increase in the levels of interleukin-1beta (IL-1beta) and IL-6, as well as tumor necrosis factor-alpha (TNF-alpha) production. Doxorubicin 81-84 interleukin 1 beta Rattus norvegicus 216-224 23807148-6 2013 The inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, significantly ameliorated DOX-induced inflammation, leading to a decrease in the levels of IL-1beta and IL-6, as well as TNF-alpha production in H9c2 cells. pyrrolidine dithiocarbamic acid 31-58 interleukin 1 beta Rattus norvegicus 194-202 23807148-6 2013 The inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, significantly ameliorated DOX-induced inflammation, leading to a decrease in the levels of IL-1beta and IL-6, as well as TNF-alpha production in H9c2 cells. pyrrolidine dithiocarbamic acid 60-64 interleukin 1 beta Rattus norvegicus 194-202 23807148-6 2013 The inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, significantly ameliorated DOX-induced inflammation, leading to a decrease in the levels of IL-1beta and IL-6, as well as TNF-alpha production in H9c2 cells. Doxorubicin 129-132 interleukin 1 beta Rattus norvegicus 194-202 23807243-5 2013 The administration of hemin lowered the plasma levels of cystatin C, creatinine, blood urea nitrogen, tumor necrosis factor alpha, interleukin 1beta, TM, and EPCR; elevated plasma level of activated protein C; prolonged prothrombin time and activated partial thromboplastin time; attenuated microthrombus formation; and upregulated the expression of TM and EPCR and mRNA levels of TM and EPCR in the kidney in the CLP + hemin group. Hemin 22-27 interleukin 1 beta Rattus norvegicus 131-148 23964314-8 2013 Bamboo salt induced a significant decrease (~80%) in mRNA and protein expression levels of COX-2, iNOS, TNF-alpha, and IL-1beta, compared with the other salts. bamboo salt 0-11 interleukin 1 beta Rattus norvegicus 119-127 23695883-0 2013 Arthritis severity locus Cia4 is an early regulator of IL-6, IL-1beta, and NF-kappaB activators" expression in pristane-induced arthritis. pristane 111-119 interleukin 1 beta Rattus norvegicus 61-69 23923069-5 2013 Our results demonstrated that propentofylline could attenuate the CCI-induced mechanical allodynia and thermal hyperalgesia and inhibit the astrocyte activation and production of IL-1beta. propentofylline 30-45 interleukin 1 beta Rattus norvegicus 179-187 23828564-3 2013 Cyclopiazonic acid (CPA)-induced ER stress enhanced the IL-1beta apoptosis in INS-1E and primary rat beta cells. cyclopiazonic acid 0-18 interleukin 1 beta Rattus norvegicus 56-64 23828564-3 2013 Cyclopiazonic acid (CPA)-induced ER stress enhanced the IL-1beta apoptosis in INS-1E and primary rat beta cells. cyclopiazonic acid 20-23 interleukin 1 beta Rattus norvegicus 56-64 23336970-6 2013 Kolaviron suppressed the DSS-mediated increase in colonic nitric oxide concentration and myeloperoxidase activity and significantly prevented the increase in inflammatory mediators, interleukin-1beta and tumour necrosis factor alpha, in the colon of DSS-treated rats. kolaviron 0-9 interleukin 1 beta Rattus norvegicus 182-232 23336970-6 2013 Kolaviron suppressed the DSS-mediated increase in colonic nitric oxide concentration and myeloperoxidase activity and significantly prevented the increase in inflammatory mediators, interleukin-1beta and tumour necrosis factor alpha, in the colon of DSS-treated rats. dss 250-253 interleukin 1 beta Rattus norvegicus 182-232 23647015-9 2013 KEY RESULTS: Quercetin and allopurinol significantly inhibited the TXNIP overexpression, activation of NLRP3 inflammasome, down-regulation of PPARalpha and up-regulation of sterol regulatory element binding protein-1c (SREBP-1c), SREBP-2, fatty acid synthase and liver X receptor alpha, as well as elevation of ROS and IL-1beta in diabetic rat liver. Quercetin 13-22 interleukin 1 beta Rattus norvegicus 319-327 23843954-7 2013 Rats treated with 10 mg/kg Carvedilol presented with significantly reduced MPO and MDA concentrations (p<0.05) in addition to presenting with reduced levels of the pro-inflammatory cytokines IL-1 beta and TNF-alpha (p<0.05). Carvedilol 27-37 interleukin 1 beta Rattus norvegicus 194-203 23843954-0 2013 Carvedilol decrease IL-1beta and TNF-alpha, inhibits MMP-2, MMP-9, COX-2, and RANKL expression, and up-regulates OPG in a rat model of periodontitis. Carvedilol 0-10 interleukin 1 beta Rattus norvegicus 20-28 23647015-9 2013 KEY RESULTS: Quercetin and allopurinol significantly inhibited the TXNIP overexpression, activation of NLRP3 inflammasome, down-regulation of PPARalpha and up-regulation of sterol regulatory element binding protein-1c (SREBP-1c), SREBP-2, fatty acid synthase and liver X receptor alpha, as well as elevation of ROS and IL-1beta in diabetic rat liver. Allopurinol 27-38 interleukin 1 beta Rattus norvegicus 319-327 24225033-7 2013 RESULTS: We found that oral sodium nitrite enhanced oxidative stress with subsequent increases in TNF-alpha (2-fold), IL-1beta (4-fold), MCP-1 (4-fold), TGF-beta1 (3-fold) and CRP (4-fold). Sodium Nitrite 28-42 interleukin 1 beta Rattus norvegicus 118-126 23619720-6 2013 The results showed that xanthotoxol treatment significantly attenuated BBB disruption, reduced the IL-1beta, TNF-alpha, IL-8 and NO level, and attenuated the iNOS activity compared with vehicle-treated animals. xanthotoxol 24-35 interleukin 1 beta Rattus norvegicus 99-107 23921080-8 2013 Oral administration of piperine resulted in significantly reduced the levels of pro-inflammatory mediators (IL-1beta, TNF-alpha and PGE2) and increased level of IL-10. piperine 23-31 interleukin 1 beta Rattus norvegicus 108-116 23671260-5 2013 Sucrose increased serum IL-1beta and -6 and hypothalamic IL-6 mRNA levels in NON and TNFalpha mRNA levels in control and NON rats, whereas NON alone had no effect. Sucrose 0-7 interleukin 1 beta Rattus norvegicus 24-61 23465391-10 2013 The tissue levels of tumor necrosis factor-alpha and interleukin-1beta were significantly higher in the saline-treated NEC group compared with the colchicine-treated NEC group (P < 0.001 and 0.003, respectively). Sodium Chloride 104-110 interleukin 1 beta Rattus norvegicus 53-70 23608519-3 2013 The histologic signs of non-muscle-invasive bladder tumors observed in BBN animals were related to 17% loss of body weight and high serum levels of IL-1beta, TNF-alpha, TWEAK, C-reactive protein, myostatin and lactate and high urinary MMPs activities, suggesting a catabolic phenotype underlying urothelial carcinoma. Butylhydroxybutylnitrosamine 71-74 interleukin 1 beta Rattus norvegicus 148-156 23885269-6 2013 Moreover, we found that H2S dramatically suppressed the release of TNF-alpha, IL-1beta and IL-6 in the hippocampus. Hydrogen Sulfide 24-27 interleukin 1 beta Rattus norvegicus 78-86 23740952-10 2013 We conclude that the synergism of IL-1beta and IFN-gamma to induce expression of the CXCL10 gene requires NF-kappaB, STAT1 phosphorylated at Tyr(701), recruitment of coactivators, and acetylation of histones H3 and H4. Tyrosine 141-144 interleukin 1 beta Rattus norvegicus 34-42 23709104-8 2013 The amount of acetylated H3K9 bound to the promoter regions of Cox-1, Cox-2, IL-1beta and NF-kappaB p65 genes, but not IL-4 in were increased in BV-2 microglia treated with acetate. Acetates 173-180 interleukin 1 beta Rattus norvegicus 77-85 23465391-10 2013 The tissue levels of tumor necrosis factor-alpha and interleukin-1beta were significantly higher in the saline-treated NEC group compared with the colchicine-treated NEC group (P < 0.001 and 0.003, respectively). Colchicine 147-157 interleukin 1 beta Rattus norvegicus 53-70 23561481-1 2013 OBJECTIVES: To investigate the effects of tetrandrine (Tet) on cognitive impairment induced by chronic cerebral hypoperfusion and its potential anti-inflammatory mechanism by modulating the expression of S100B, interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and inducible nitric oxide synthase (iNOS). tetrandrine 42-53 interleukin 1 beta Rattus norvegicus 211-229 23073826-6 2013 As compared to controls, Pb exposure significantly enhanced the expression of Iba-1 immunoreactivity; increased the expression levels of IL-1beta, IL-6, and TNF-alpha and decreased the numbers of BrdU(+) and doublecortin(+) cells. Lead 25-27 interleukin 1 beta Rattus norvegicus 137-145 23561481-1 2013 OBJECTIVES: To investigate the effects of tetrandrine (Tet) on cognitive impairment induced by chronic cerebral hypoperfusion and its potential anti-inflammatory mechanism by modulating the expression of S100B, interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and inducible nitric oxide synthase (iNOS). tetrandrine 42-53 interleukin 1 beta Rattus norvegicus 231-240 23561481-1 2013 OBJECTIVES: To investigate the effects of tetrandrine (Tet) on cognitive impairment induced by chronic cerebral hypoperfusion and its potential anti-inflammatory mechanism by modulating the expression of S100B, interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and inducible nitric oxide synthase (iNOS). tet 55-58 interleukin 1 beta Rattus norvegicus 211-229 23561481-1 2013 OBJECTIVES: To investigate the effects of tetrandrine (Tet) on cognitive impairment induced by chronic cerebral hypoperfusion and its potential anti-inflammatory mechanism by modulating the expression of S100B, interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and inducible nitric oxide synthase (iNOS). tet 55-58 interleukin 1 beta Rattus norvegicus 231-240 23561481-9 2013 Additionally, S100B, IL-1 beta, TNF-alpha, and iNOS levels were significantly (P <0.05) decreased in the CA1 region of the chronic cerebral hypoperfusion affected rats treated with Tet. tet 184-187 interleukin 1 beta Rattus norvegicus 21-30 23561481-11 2013 Tetrandrine may be a novel and promising candidate for future treatment and/or prevention of chronic cerebral hypoperfusion via inhibiting S100B activation and decreasing the expression of IL-1 beta, TNF-alpha, and iNOS in the hippocampal CA1 region. tetrandrine 0-11 interleukin 1 beta Rattus norvegicus 189-198 23823010-7 2013 Although, TCDD led to a significant increase in TNF-alpha and IL-1beta levels, hesperidin treatment was able to normalize these values in rats. Polychlorinated Dibenzodioxins 10-14 interleukin 1 beta Rattus norvegicus 62-70 25867037-8 2013 The n-3 fatty acid-fortified diet was found to have potent immunopotentiating and anti-inflammatory effects in the group receiving this diet, as evidenced by total blood lymphocyte count and plasma levels of interleukin-1 beta (IL-1beta) and sialic acid on day 1 after wounding. Fatty Acids, Omega-3 4-18 interleukin 1 beta Rattus norvegicus 208-226 25867037-8 2013 The n-3 fatty acid-fortified diet was found to have potent immunopotentiating and anti-inflammatory effects in the group receiving this diet, as evidenced by total blood lymphocyte count and plasma levels of interleukin-1 beta (IL-1beta) and sialic acid on day 1 after wounding. Fatty Acids, Omega-3 4-18 interleukin 1 beta Rattus norvegicus 228-236 23485816-10 2013 Celecoxib administration significantly attenuated systemic LPS-induced increments in the number of activated microglia and astrocytes, concentrations of IL-1beta and TNFalpha, and protein levels of phosphorylated-p38 MAPK in the neonatal rat brain. Celecoxib 0-9 interleukin 1 beta Rattus norvegicus 153-161 23043675-6 2013 AM251 attenuated JZL184-induced decreases in frontal cortical IL-1beta expression. JZL 184 17-23 interleukin 1 beta Rattus norvegicus 62-70 23600830-0 2013 Ethyl pyruvate significantly inhibits tumour necrosis factor-alpha, interleukin-1beta and high mobility group box 1 releasing and attenuates sodium taurocholate-induced severe acute pancreatitis associated with acute lung injury. ethyl pyruvate 0-14 interleukin 1 beta Rattus norvegicus 68-85 23313315-0 2013 Isoflurane postconditioning reduces ischemia-induced nuclear factor-kappaB activation and interleukin 1beta production to provide neuroprotection in rats and mice. Isoflurane 0-10 interleukin 1 beta Rattus norvegicus 90-107 23543229-8 2013 Glibenclamide did not affect leukocyte infiltration, IL-1beta release and PGE2 production, but only reduced IL-1beta production by MSU-stimulated macrophages at very high concentration (200 muM). Glyburide 0-13 interleukin 1 beta Rattus norvegicus 108-116 23543229-9 2013 Dexamethasone significantly reduced leukocyte infiltration, IL-1beta release and PGE2 production. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 60-68 23619555-9 2013 Treatment of FLS with ADMA also significantly increased the levels of IL-1beta and IL-6, and reduced the expression of CST. N,N-dimethylarginine 22-26 interleukin 1 beta Rattus norvegicus 70-78 23122581-8 2013 In addition, NaHS inhibited the production of interleukin 1beta but increased interleukin 10 levels in graft lung tissues. sodium bisulfide 13-17 interleukin 1 beta Rattus norvegicus 46-63 23313315-6 2013 Isoflurane postconditioning reduced brain ischemia/reperfusion-induced nuclear transcription factor (NF)-kappaB (NF-kappaB) activation as well as interleukin 1beta (IL-1beta) and interleukin-6 production in the ischemic penumbral brain tissues at 24h after the MCAO. Isoflurane 0-10 interleukin 1 beta Rattus norvegicus 146-163 23474429-10 2013 Maternal MgCl2 supplementation significantly decreased IL-1beta, TNF-alpha, and CCL2 levels in AF and IL-1beta in PL tissues of MgBL vs BL rats (P < .0001). Magnesium Chloride 9-14 interleukin 1 beta Rattus norvegicus 55-63 23512809-2 2013 We recently demonstrated that Cohen diabetic sensitive (CDs) rats fed a high-sucrose, low-copper diet (HSD) developed hyperglycemia and reduced GSIS in association with peri-islet infiltration of fat and interleukin (IL)-1beta-expressing macrophages, whereas CD resistant (CDr) rats remained normoglycemic on HSD. cds 56-59 interleukin 1 beta Rattus norvegicus 204-226 23512809-2 2013 We recently demonstrated that Cohen diabetic sensitive (CDs) rats fed a high-sucrose, low-copper diet (HSD) developed hyperglycemia and reduced GSIS in association with peri-islet infiltration of fat and interleukin (IL)-1beta-expressing macrophages, whereas CD resistant (CDr) rats remained normoglycemic on HSD. Cadmium 56-58 interleukin 1 beta Rattus norvegicus 204-226 23512809-3 2013 We examined: 1) the correlation between copper concentration in the HSD and progression, prevention, and reversion of hyperglycemia in CDs rats, 2) the relationship between activity of the copper-dependent, respiratory-chain enzyme cytochrome c oxidase (COX), infiltration of fat, IL-1beta-expressing macrophages, and defective GSIS in hyperglycemic CDs rats. Copper 189-195 interleukin 1 beta Rattus norvegicus 281-289 23512809-9 2013 CDs rats maintained on copper-supplemented HSD did not develop hyperglycemia, and in hyperglycemic CDs rats, copper supplementation restored GSIS and COX activity, reversed hyperglycemia and infiltration of fat and IL-1beta-expressing macrophages (P < 0.01 vs. hyperglycemic CDs-HSD rats, all parameters, respectively). Copper 109-115 interleukin 1 beta Rattus norvegicus 215-223 24252536-8 2013 Injection of interleukin-1 beta caused higher numbers of blood vessels with perivascular, cellular C1q reactivity than any other cytokine tested. C10Ph 99-102 interleukin 1 beta Rattus norvegicus 13-31 23470622-4 2013 Compared with cells from control rats, cultured PA-SMCs from MCT-PH rats exhibited increased growth responses to platelet-derived growth factor, serotonin (5-hydroxytryptophan), IL-1beta, insulin-like growth factor-1, or fetal calf serum (FCS), with increases in phosphorylated (Ser-473)Akt, (Thr-308)Akt, glycogen synthase kinase (GSK)3, and S6K reflecting activated mTORC1 and mTORC2 signaling. pa-smcs 48-55 interleukin 1 beta Rattus norvegicus 178-186 23541724-13 2013 Aspirin and ibuprofen also reversed the increased wall thickness, macroscopic damage and levels of IL-1beta, IL-6 and PGE2, and the decreased panthotenic acid levels. Aspirin 0-7 interleukin 1 beta Rattus norvegicus 99-107 23541724-13 2013 Aspirin and ibuprofen also reversed the increased wall thickness, macroscopic damage and levels of IL-1beta, IL-6 and PGE2, and the decreased panthotenic acid levels. Ibuprofen 12-21 interleukin 1 beta Rattus norvegicus 99-107 23474429-10 2013 Maternal MgCl2 supplementation significantly decreased IL-1beta, TNF-alpha, and CCL2 levels in AF and IL-1beta in PL tissues of MgBL vs BL rats (P < .0001). Magnesium Chloride 9-14 interleukin 1 beta Rattus norvegicus 102-110 22932066-5 2013 MEK inhibitors--PD98059 and U0126--blocked the effect of bFGF on phosphorylated CREB while a p38-MAPK inhibitor--SB203580--blocked the effect of IL1beta on phosphorylated CREB. SB 203580 113-121 interleukin 1 beta Rattus norvegicus 145-152 23494565-6 2013 In addition, sinapic acid treatment significantly attenuated the CCl4-induced production of inflammatory mediators, including tumor necrosis factor-alpha and interleukin-1beta mRNA levels, and increased the expression of nuclear factor-kappa B (NF-kappaB p65). sinapinic acid 13-25 interleukin 1 beta Rattus norvegicus 158-175 23357470-0 2013 Heroin-induced conditioned immunomodulation requires expression of IL-1beta in the dorsal hippocampus. Heroin 0-6 interleukin 1 beta Rattus norvegicus 67-75 23357470-3 2013 Thus, the present study evaluated whether the dorsal hippocampus (DH), and more specifically interleukin-1 beta (IL-1beta) within the DH, is necessary for the expression of heroin-induced conditioned immunomodulation. Heroin 173-179 interleukin 1 beta Rattus norvegicus 93-111 23357470-3 2013 Thus, the present study evaluated whether the dorsal hippocampus (DH), and more specifically interleukin-1 beta (IL-1beta) within the DH, is necessary for the expression of heroin-induced conditioned immunomodulation. Heroin 173-179 interleukin 1 beta Rattus norvegicus 113-121 23357470-9 2013 Inactivation of, or IL-1beta silencing in, the DH disrupted the CS-induced suppression of nitric oxide production relative to vehicle or negative control siRNA treatment. Cesium 64-66 interleukin 1 beta Rattus norvegicus 20-28 23357470-9 2013 Inactivation of, or IL-1beta silencing in, the DH disrupted the CS-induced suppression of nitric oxide production relative to vehicle or negative control siRNA treatment. Nitric Oxide 90-102 interleukin 1 beta Rattus norvegicus 20-28 23542012-7 2013 The 25 and 50 mg/kg of lithium decreased the level of interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and the tumor necrosis factor-alpha (TNF-alpha) in the serum, and the 8-iso-prostaglandin F2alpha (8-ISO) level in lung tissue. Lithium 23-30 interleukin 1 beta Rattus norvegicus 54-72 23542012-7 2013 The 25 and 50 mg/kg of lithium decreased the level of interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and the tumor necrosis factor-alpha (TNF-alpha) in the serum, and the 8-iso-prostaglandin F2alpha (8-ISO) level in lung tissue. Lithium 23-30 interleukin 1 beta Rattus norvegicus 74-82 22932066-7 2013 PD98059 blocked the ability of bFGF to stimulate Ldh A expression and SB203580 blocked the ability of IL1beta to stimulate Ldh A expression and LDH activity. SB 203580 70-78 interleukin 1 beta Rattus norvegicus 102-109 23238043-10 2013 TNF-alpha and IL-1beta levels were increased in the serum and CSF of deprived rats treated with saline (p<0.05). Sodium Chloride 96-102 interleukin 1 beta Rattus norvegicus 14-22 23508312-4 2013 Our results showed that anesthetic isoflurane increased the hippocampal mRNA level of IL-1beta, while surgery of partial hepatectomy increased the hippocampal mRNA levels of IL-1beta, TNF-alpha, and IL-6 as well as impaired rats" spatial memory at day 7 post-surgery. Isoflurane 35-45 interleukin 1 beta Rattus norvegicus 86-94 23422878-4 2013 Ethanol-exposed rats showed impaired spatial navigation in the Morris water maze test and poor retention in the elevated plus maze task which was coupled with enhanced acetylcholinesterase activity, increased oxidative-nitrosative stress, cytokines (TNF-alpha and IL-1beta), NF-kappa beta and caspase-3 levels in different brain regions (cerebral cortex and hippocampus) of ethanol-treated rats. Ethanol 0-7 interleukin 1 beta Rattus norvegicus 264-272 23422878-6 2013 Correlatively, the results of the present study revealed that treatment with resveratrol significantly prevented cognitive deficits induced by chronic ethanol exposure not only by modulating oxido-nitrosative stress but also by attenuating the enhanced levels of pro-inflammatory cytokines (TNF-alpha and IL-1beta), NF-kbeta and caspase-3 in different brain regions of ethanol treated rats. Resveratrol 77-88 interleukin 1 beta Rattus norvegicus 305-313 23422878-6 2013 Correlatively, the results of the present study revealed that treatment with resveratrol significantly prevented cognitive deficits induced by chronic ethanol exposure not only by modulating oxido-nitrosative stress but also by attenuating the enhanced levels of pro-inflammatory cytokines (TNF-alpha and IL-1beta), NF-kbeta and caspase-3 in different brain regions of ethanol treated rats. Ethanol 151-158 interleukin 1 beta Rattus norvegicus 305-313 23677262-1 2013 OBJECTIVE: To test the hypothesis that the neurohormone, melatonin, differentially activates the release of the proinflammatory cytokines, such as, interleukin-1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as inducing leukocyte mobilization into the peripheral blood in response to a sterile tissue injury. Melatonin 57-66 interleukin 1 beta Rattus norvegicus 148-166 23677262-1 2013 OBJECTIVE: To test the hypothesis that the neurohormone, melatonin, differentially activates the release of the proinflammatory cytokines, such as, interleukin-1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as inducing leukocyte mobilization into the peripheral blood in response to a sterile tissue injury. Melatonin 57-66 interleukin 1 beta Rattus norvegicus 168-176 23677262-4 2013 RESULTS: Melatonin treatment and sterile tissue injuries significantly (p<0.05) increased the plasma levels of IL-1beta and TNF-alpha compared to baseline levels. Melatonin 9-18 interleukin 1 beta Rattus norvegicus 114-122 23677262-5 2013 However, higher levels of IL-1beta compared with TNF-alpha were obtained only with melatonin treatment. Melatonin 83-92 interleukin 1 beta Rattus norvegicus 26-34 23677262-8 2013 CONCLUSION: Melatonin differentially stimulated plasma IL-1beta and TNF-alpha, and increased blood leukocyte counts before and after sterile tissue injuries. Melatonin 12-21 interleukin 1 beta Rattus norvegicus 55-63 23613842-7 2013 We found that pretreatment with minocycline mitigated isoflurane-induced cognitive deficits and suppressed the isoflurane-induced excessive release of IL-1beta and caspase-3 in the hippocampal CA1 region at 4 h after isoflurane exposure, as well as the number of TUNEL-positive nuclei. Minocycline 32-43 interleukin 1 beta Rattus norvegicus 151-159 23613842-7 2013 We found that pretreatment with minocycline mitigated isoflurane-induced cognitive deficits and suppressed the isoflurane-induced excessive release of IL-1beta and caspase-3 in the hippocampal CA1 region at 4 h after isoflurane exposure, as well as the number of TUNEL-positive nuclei. Isoflurane 111-121 interleukin 1 beta Rattus norvegicus 151-159 23613842-7 2013 We found that pretreatment with minocycline mitigated isoflurane-induced cognitive deficits and suppressed the isoflurane-induced excessive release of IL-1beta and caspase-3 in the hippocampal CA1 region at 4 h after isoflurane exposure, as well as the number of TUNEL-positive nuclei. Isoflurane 111-121 interleukin 1 beta Rattus norvegicus 151-159 23593390-11 2013 Restricted-iron adult rats showed an increase in heart Ftl mRNA and the enriched-iron adult rats showed an increase in liver nuclear factor erythroid derived 2 like 2 (Nfe2l2) and Il1b mRNAs and in gut divalent metal transporter-1 mRNA (Slc11a2) relative to the control adult group. Iron 81-85 interleukin 1 beta Rattus norvegicus 180-184 24195349-1 2013 A significant increase in serum lipase, amylase, capase-1 and myeloperoxidase activities, oxidative stress index (OSI), IL-1beta and IL-18 was observed in rats receiving ethanol (EtOH) and high fat diet (HFD). Ethanol 170-177 interleukin 1 beta Rattus norvegicus 120-128 23561827-10 2013 Celecoxib administration significantly attenuated LPS-induced increases in the numbers of activated microglia and astrocytes and in the concentration of IL-1beta in the neonatal rat brain. Celecoxib 0-9 interleukin 1 beta Rattus norvegicus 153-161 23596475-0 2013 Ketamine exerts antidepressant effects and reduces IL-1beta and IL-6 levels in rat prefrontal cortex and hippocampus. Ketamine 0-8 interleukin 1 beta Rattus norvegicus 51-59 23596475-10 2013 In addition, the ketamine group demonstrated a statistically significant decrease in the expression of IL-1beta and IL-6 in rat prefrontal cortex and hippocampus compared with the saline group (P<0.05). Ketamine 17-25 interleukin 1 beta Rattus norvegicus 103-111 23596475-11 2013 Ketamine-induced antidepressant effects are associated with decreased levels of IL-1beta and IL-6 in rat prefrontal cortex and hippocampus. Ketamine 0-8 interleukin 1 beta Rattus norvegicus 80-88 22891744-0 2013 Diazepam reverses the alveolar bone loss and hippocampal interleukin-1beta and interleukin-6 enhanced by conditioned fear stress in ligature-induced periodontal disease in rats. Diazepam 0-8 interleukin 1 beta Rattus norvegicus 57-74 22891744-11 2013 In addition, diazepam treatment led to decreased IL-1beta and IL-6 levels in the hippocampus. Diazepam 13-21 interleukin 1 beta Rattus norvegicus 49-57 23142117-5 2013 RESULTS: Nitrite treatment was associated with better oxygenation, lower peak airway pressure, lower wet/dry ratio, reduced myeloperoxidase level and macrophage infiltration, increased cyclic guanosine monophosphate (cGMP) levels, and decreased levels of interleukin 6, interleukin 1-beta, inducible nitric oxide synthase, and intercellular adhesion molecule-1 at 2 hours after reperfusion. Nitrites 9-16 interleukin 1 beta Rattus norvegicus 270-288 23756390-9 2013 Combination of reduced dose of indomethacin and GS-HCl significantly reduced the expressions of ICAM-1, VCAM-1, IL-8, IL-1beta, MMP-2, MMP-7, MMP-9, and MMP-11 mRNA as well as NF-kappaB activation better than high dose indomethacin alone. Indomethacin 31-43 interleukin 1 beta Rattus norvegicus 118-126 23756390-9 2013 Combination of reduced dose of indomethacin and GS-HCl significantly reduced the expressions of ICAM-1, VCAM-1, IL-8, IL-1beta, MMP-2, MMP-7, MMP-9, and MMP-11 mRNA as well as NF-kappaB activation better than high dose indomethacin alone. gs-hcl 48-54 interleukin 1 beta Rattus norvegicus 118-126 23537341-7 2013 Minocycline, a microglia inhibitor, blocked the facilitatory effect of IL-1beta on AMPA- but not NMDA-induced currents, where minocycline itself depressed NMDA- but had not any effects on AMPA-induced currents. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 83-87 interleukin 1 beta Rattus norvegicus 71-79 23287539-11 2013 In contrast, both hinokiresinols suppressed neutrophil infiltration and IL-1beta release to a similar extent. hinokiresinol 18-32 interleukin 1 beta Rattus norvegicus 72-80 23404506-4 2013 Real time PCR showed that PGE2 had no effect on expression of CXCL10, TGF-beta1, and IL-11 and exacerbated the rapid up-regulation of mRNAs encoding cyclooxygenase-2, inducible NOS, IL-6, and IL-1beta but blunted the production of mRNAs encoding TNF-alpha, IL-10, CCL3, and CCL4. Dinoprostone 26-30 interleukin 1 beta Rattus norvegicus 192-200 23537341-4 2013 RESULTS: AMPA- and NMDA-induced currents were increased in peak amplitude by IL-1beta in a manner different from each other in SG neurons. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 9-13 interleukin 1 beta Rattus norvegicus 77-85 23537341-4 2013 RESULTS: AMPA- and NMDA-induced currents were increased in peak amplitude by IL-1beta in a manner different from each other in SG neurons. N-Methylaspartate 19-23 interleukin 1 beta Rattus norvegicus 77-85 23537341-8 2013 CONCLUSIONS: IL-1beta enhances AMPA and NMDA responses in SG neurons through IL-1R activation; the former but not latter action is reversible and due to an increase in neuronal activity in a manner dependent on extracellular Ca2+ and minocycline. N-Methylaspartate 40-44 interleukin 1 beta Rattus norvegicus 13-21 23537341-6 2013 The AMPA- but not NMDA-induced current facilitated by IL-1beta was recovered to control level 30 min after IL-1beta washout and largely depressed in Na+-channel blocker tetrodotoxin-containing or nominally Ca2+-free Krebs solution. Tetrodotoxin 169-181 interleukin 1 beta Rattus norvegicus 54-62 23537341-8 2013 CONCLUSIONS: IL-1beta enhances AMPA and NMDA responses in SG neurons through IL-1R activation; the former but not latter action is reversible and due to an increase in neuronal activity in a manner dependent on extracellular Ca2+ and minocycline. Minocycline 234-245 interleukin 1 beta Rattus norvegicus 13-21 23537341-6 2013 The AMPA- but not NMDA-induced current facilitated by IL-1beta was recovered to control level 30 min after IL-1beta washout and largely depressed in Na+-channel blocker tetrodotoxin-containing or nominally Ca2+-free Krebs solution. krebs 216-221 interleukin 1 beta Rattus norvegicus 54-62 23333234-5 2013 METHODS: LPS or LOS was administered intravenously (IV) or intranasally (IN) 2h pre- or post-injection of IL-1beta. lipid-linked oligosaccharides 16-19 interleukin 1 beta Rattus norvegicus 106-114 23537341-7 2013 Minocycline, a microglia inhibitor, blocked the facilitatory effect of IL-1beta on AMPA- but not NMDA-induced currents, where minocycline itself depressed NMDA- but had not any effects on AMPA-induced currents. Minocycline 0-11 interleukin 1 beta Rattus norvegicus 71-79 23622648-11 2013 CsA-induced nephrotoxicity was accompanied by kidney overexpression of inflammatory and proliferative mRNA markers (IL-1beta, mTOR and PCNA), which were absent among SRL group. Cyclosporine 0-3 interleukin 1 beta Rattus norvegicus 116-124 23376060-7 2013 Intraventricular microinjection of recombinant rat IL-1beta aggravated cerebral ischemic injury, which was significantly reduced by memantine. Memantine 132-141 interleukin 1 beta Rattus norvegicus 51-59 22976935-8 2013 Downstream inflammasome proteins like IL-1beta and caspase 1 increased within the prostate and decreased with CHA treatment. Chlorogenic Acid 110-113 interleukin 1 beta Rattus norvegicus 38-46 23532269-6 2013 The administration of LPS resulted in a significant increase in TNF-alpha and IL-1beta levels, 7- and 3.5-fold, respectively (P < 0.05), while treatment with propofol partially blunted the secretion of both cytokines (P < 0.05). Propofol 161-169 interleukin 1 beta Rattus norvegicus 78-86 23429466-9 2013 RESULTS: PG-PS-injected rats treated with anti-TNFalpha had less histologic inflammation, and cecal tissue expressed lower levels of proinflammatory cytokine messenger RNAs than vehicle-treated PG-PS-injected rats (IL-1beta: 5.59 +- 1.53 versus 10.41 +- 1.78, P = 0.02; IL-6: 23.23 +- 9.33 versus 45.89 +- 11.79, P = 0.07). PG-PS 9-14 interleukin 1 beta Rattus norvegicus 215-223 23415748-15 2013 maprotiline at all applied doses noticeably declined levels of IL-1beta into the site of inflammation, while only i.p. Maprotiline 0-11 interleukin 1 beta Rattus norvegicus 63-71 23415748-19 2013 maprotiline in the carrageenan induced paw edema model and showed that these properties of maprotiline might be mediated through inhibition of PMN infiltration and release of IL-1beta and TNF-alpha. Maprotiline 91-102 interleukin 1 beta Rattus norvegicus 175-183 23233245-1 2013 Acetate supplementation attenuates neuroglia activation in a rat model of neuroinflammation by a mechanism associated with an increase in brain acetyl-CoA, an alteration in histone acetylation, and reduction of interleukin (IL)-1beta expression. Acetates 0-7 interleukin 1 beta Rattus norvegicus 211-233 23233245-3 2013 Using primary astroglial cultures, we found that LPS (0-25 ng/ml, 4 h) increased tumor necrosis factor (TNF-alpha) and IL-1beta in a concentration-dependent manner, which was reduced by treatment with sodium acetate (12 mM). Sodium Acetate 201-215 interleukin 1 beta Rattus norvegicus 119-127 23507231-0 2013 Phosphatidylserine inhibits inflammatory responses in interleukin-1beta-stimulated fibroblast-like synoviocytes and alleviates carrageenan-induced arthritis in rat. Phosphatidylserines 0-18 interleukin 1 beta Rattus norvegicus 54-71 22585561-9 2013 Resveratrol significantly inhibited LPS-induced microglial activation and subsequent production of multiple pro-inflammatory and cytotoxic factors such as tumor necrosis factor-alpha, nitric oxide, and interleukin-1beta. Resveratrol 0-11 interleukin 1 beta Rattus norvegicus 202-219 23426662-6 2013 TNFalpha or IL-1beta sharply increased both mRNA and protein for GDNF, while the neurotrophic effects of TNFalpha or IL-1beta were blocked by the RET-receptor blocker vandetanib. vandetanib 167-177 interleukin 1 beta Rattus norvegicus 12-20 23200736-5 2013 The results showed that tigecycline significantly attenuated the expression and the release of nuclear factor-kappa beta (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), as well as nitric oxide (NO) levels in LPS-induced PC12 cells. Tigecycline 24-35 interleukin 1 beta Rattus norvegicus 178-195 23200736-5 2013 The results showed that tigecycline significantly attenuated the expression and the release of nuclear factor-kappa beta (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), as well as nitric oxide (NO) levels in LPS-induced PC12 cells. Tigecycline 24-35 interleukin 1 beta Rattus norvegicus 197-205 23401543-5 2013 Similarly, oligodeoxynucleotide-antisense against COX-1 or COX-2, but not oligodeoxynucleotide-mismatch, decreased their respective expressions in the L5-DRG and prevented the hyperalgesia induced by IL-1beta in the hindpaw. Oligodeoxyribonucleotides 11-31 interleukin 1 beta Rattus norvegicus 200-208 23426662-6 2013 TNFalpha or IL-1beta sharply increased both mRNA and protein for GDNF, while the neurotrophic effects of TNFalpha or IL-1beta were blocked by the RET-receptor blocker vandetanib. vandetanib 167-177 interleukin 1 beta Rattus norvegicus 117-125 23201589-3 2013 Poly I:C induced a neuroinflammatory response characterised by increased expression of IL-1beta, IL-6, TNF-alpha and CD11b in frontal cortex and hippocampus. Poly I-C 0-8 interleukin 1 beta Rattus norvegicus 87-95 23275614-9 2013 In the experiment using isolated Kupffer cells, the expression of interleukin-6, interleukin-1beta, and endothelin-1 in response to LPS stimulation was attenuated by BCAA in a dose-dependent fashion. Amino Acids, Branched-Chain 166-170 interleukin 1 beta Rattus norvegicus 81-98 23331247-8 2013 Suppressions of AGEs, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-beta) in serum of MG-induced rats were attenuated in the monascin administration group treated with retinoic acid (RA). Pyruvaldehyde 107-109 interleukin 1 beta Rattus norvegicus 67-84 23331247-8 2013 Suppressions of AGEs, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-beta) in serum of MG-induced rats were attenuated in the monascin administration group treated with retinoic acid (RA). monascin 146-154 interleukin 1 beta Rattus norvegicus 67-84 23331247-8 2013 Suppressions of AGEs, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-beta) in serum of MG-induced rats were attenuated in the monascin administration group treated with retinoic acid (RA). Tretinoin 189-202 interleukin 1 beta Rattus norvegicus 67-84 23302986-7 2013 Isoflurane"s preconditioning effect was assessed by histologic examination, protein content, neutrophil recruitment, and determination of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 levels in bronchoalveolar lavage fluid and lung tissue. Isoflurane 0-10 interleukin 1 beta Rattus norvegicus 173-195 23302986-10 2013 RESULTS: Isoflurane preconditioning reduced inflammatory lung injury and TNF-alpha, IL-1beta, and IL-6 release in the lung. Isoflurane 9-19 interleukin 1 beta Rattus norvegicus 84-92 23270609-5 2013 We found that pretreatment with minocycline remarkably alleviated isoflurane-induced cognitive dysfunction and inhibited the isoflurane-induced over expression of TNF-alpha, IL-1beta, and IL-6, possibly by inhibiting the degradation of IkappaBalpha. Minocycline 32-43 interleukin 1 beta Rattus norvegicus 174-182 23270609-5 2013 We found that pretreatment with minocycline remarkably alleviated isoflurane-induced cognitive dysfunction and inhibited the isoflurane-induced over expression of TNF-alpha, IL-1beta, and IL-6, possibly by inhibiting the degradation of IkappaBalpha. Isoflurane 125-135 interleukin 1 beta Rattus norvegicus 174-182 23331247-8 2013 Suppressions of AGEs, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-beta) in serum of MG-induced rats were attenuated in the monascin administration group treated with retinoic acid (RA). Tretinoin 204-206 interleukin 1 beta Rattus norvegicus 67-84 23261364-8 2013 Treatment with different concentrations of beta-glucan for 12h activated Dectin1/Syk, which subsequently suppressed TLR4, MyD88 and NF-kappaB expression and TNF-alpha and IL-1beta secretion. beta-Glucans 43-54 interleukin 1 beta Rattus norvegicus 171-179 22978269-7 2013 We found DMHP inhibited secondary hind paw swelling and arthritis index, and decreased TNF-alpha and IL-1beta serum levels in AA rats. 3-(1,2-dimethylheptyl)-7,8,9,10-tetrahydro-6,6,9-trimethyl-6H-dibenzo(b,d)pyran-1-ol 9-13 interleukin 1 beta Rattus norvegicus 101-109 23138560-5 2013 Furthermore, blockade of ERG1 channels with E4031 down-regulated the mature of ERG1 protein, inhibited NF-kappaB translocation into the nucleus, and reduced LPS-stimulated IL-6 and IL-1beta secretion. E 4031 44-49 interleukin 1 beta Rattus norvegicus 181-189 23569141-6 2013 RESULTS: At 24 h after SCI, apoptosis and TNFalpha, IL-1beta and MPO concentrations were significantly lower in the rosiglitazone group than in the vehicle and SCI groups. Rosiglitazone 116-129 interleukin 1 beta Rattus norvegicus 52-60 23354246-11 2013 Dexmedetomidine not only significantly modified hemodynamics and relieved the infiltration of inflammatory cells into alveolar spaces but also inhibited the plasma TNF-alpha and IL-1beta production as well as the lung NF-kappaB activation (p < 0.05, respectively). Dexmedetomidine 0-15 interleukin 1 beta Rattus norvegicus 178-186 22727944-6 2013 Cytokines, namely tumor necrosis factor-alpha and interleukin-1beta, released into the conditioned media of PA-treated astrocytes activate neural and acidic SMase in the neurons. Palmitic Acid 108-110 interleukin 1 beta Rattus norvegicus 50-67 22660838-9 2013 The STZ group showed elevated level of nitric oxide, tumor necrosis factor-alpha, and interleukin-1beta in serum which were decreased by PYC treatment. Streptozocin 4-7 interleukin 1 beta Rattus norvegicus 86-103 23324889-0 2013 Activation of the heat shock response attenuates the interleukin 1beta-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport. Amiloride 98-107 interleukin 1 beta Rattus norvegicus 53-70 23443766-7 2013 IL-1beta concentration was significantly lower in early TAT-NBD intervention group (15.348-+0.812 pg/ml) than in bilirubin group (P<0.05). Bilirubin 113-122 interleukin 1 beta Rattus norvegicus 0-8 23000924-6 2013 Crotonaldehyde caused inhibition of NO, TNF-alpha, IL-1beta and IL-12 production in AMs treated with lipopolysaccharide (LPS), which is probably related to inhibition of NF-kappaB activation. 2-butenal 0-14 interleukin 1 beta Rattus norvegicus 51-59 22944319-4 2013 Prior isoproterenol treatment significantly enhanced IL-1beta and IL-6, but not TNF-alpha production following LPS stimulation. Isoproterenol 6-19 interleukin 1 beta Rattus norvegicus 53-61 23261498-11 2013 Pretreatment with hemin or DMDC reduced neutrophil infiltration and TNF-alpha, IL-1beta, and MDA formation, and increased the levels of GSH and mucus in the gastric tissue. Hemin 18-23 interleukin 1 beta Rattus norvegicus 79-87 23261498-11 2013 Pretreatment with hemin or DMDC reduced neutrophil infiltration and TNF-alpha, IL-1beta, and MDA formation, and increased the levels of GSH and mucus in the gastric tissue. dimanganese decacarbonyl 27-31 interleukin 1 beta Rattus norvegicus 79-87 23159886-7 2013 Similarly, MB and/or PQ-mediated histopathological symptoms and changes in the catalytic activities/expressions of CYP1A2, CYP2E1, iNOS, TNF-alpha, and IL-1beta were alleviated by NAC and SIL. Paraquat 21-23 interleukin 1 beta Rattus norvegicus 152-160 23159886-7 2013 Similarly, MB and/or PQ-mediated histopathological symptoms and changes in the catalytic activities/expressions of CYP1A2, CYP2E1, iNOS, TNF-alpha, and IL-1beta were alleviated by NAC and SIL. Acetylcysteine 180-183 interleukin 1 beta Rattus norvegicus 152-160 23021418-2 2013 STZ produced significant increase in proinflammatory cytokines (TNF-alpha and IL-1beta), ROS, nitrite and mRNA and protein expression of iNOS and nNOS indicating a state of neuroinflammation in rat brain which was significantly prevented by Memantine and Ibuprofen treatment. Streptozocin 0-3 interleukin 1 beta Rattus norvegicus 78-86 22890678-12 2013 IL-1beta was significantly elevated following the induction of SAH but was inhibited by high-dose simvastatin. Simvastatin 98-109 interleukin 1 beta Rattus norvegicus 0-8 23146752-12 2013 Moreover, the hepatic mRNA expression and serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) were significantly increased in CCl(4)-treated rats and attenuated by co-treatment with CGA. Cefaclor 185-188 interleukin 1 beta Rattus norvegicus 124-141 23146752-12 2013 Moreover, the hepatic mRNA expression and serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) were significantly increased in CCl(4)-treated rats and attenuated by co-treatment with CGA. Cefaclor 185-188 interleukin 1 beta Rattus norvegicus 143-151 23085209-4 2013 We measured the effects of each fraction or constituent thereof on the induction of the inflammatory mediator nitric oxide (NO), which was induced by interleukin 1beta in primary cultured rat hepatocytes. Nitric Oxide 110-122 interleukin 1 beta Rattus norvegicus 150-167 23085209-5 2013 The hydrophobic fraction markedly suppressed NO induction and reduced the expression of inducible nitric oxide syntheses (iNOS) in interleukin 1beta-treated hepatocytes. Nitric Oxide 98-110 interleukin 1 beta Rattus norvegicus 131-148 24020061-9 2013 Ketofol decreased the level of TNF-alpha and IL-1beta in plasma, as well as expression of cyclooxygenase-2 mRNA and the nitrate/nitrite level in lung tissue. Ketofol 0-7 interleukin 1 beta Rattus norvegicus 45-53 23221506-7 2013 Furthermore, TNF-alpha/protein and IL-1beta/protein levels in the samples of animals treated with raloxifene (23.27 +- 5.27 pg/mg and 6.09 +- 0.77 pg/mg, respectively) were significantly lower than those taken from group B (P = 0.002 and P = 0.002, respectively). Raloxifene Hydrochloride 98-108 interleukin 1 beta Rattus norvegicus 35-43 23392928-10 2013 Meanwhile, the serum concentrations of TNF-alpha and IL-1beta were significantly increased, which were significantly attenuated by taurine administration. Taurine 131-138 interleukin 1 beta Rattus norvegicus 53-61 23548128-6 2013 The findings showed that RA inhibited Cd(2+) -mediated cell toxicity, reactive oxygen species generation, interleukin (IL)-6 and IL-1beta production, the translocation of the apoptosis inducing factor into the nucleus and activation of caspases-3 in an auditory cell line, HEI-OC1. rosmarinic acid 25-27 interleukin 1 beta Rattus norvegicus 129-137 23221506-10 2013 CONCLUSION: A single dose of 3.0 mg/kg of raloxifene intraperitoneally given 30 minutes after the induction of SCI reduced the production of TNF-alpha and IL-1beta 6 hours after SCI and attenuated ultrastructural changes in a rat model. Raloxifene Hydrochloride 42-52 interleukin 1 beta Rattus norvegicus 155-163 23338062-8 2013 Rebamipide reduced the expression of matrix metalloproteinase 13, interleukin-1beta, inducible nitric oxide synthase, and nitrotyrosine in OA cartilage. rebamipide 0-10 interleukin 1 beta Rattus norvegicus 66-83 23714389-0 2013 Response to "TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1beta-induced rat osteoarthritis chondrocytes in vitro". ferulic acid 107-122 interleukin 1 beta Rattus norvegicus 126-134 23111331-5 2013 In the CHOL group, the expression levels of pro-inflammatory genes, including IL-1beta, IL-1alpha, iNOS, and COX-2, were elevated. Cholesterol 7-11 interleukin 1 beta Rattus norvegicus 78-86 23218603-3 2013 Diacerein is an anthraquinone derivative with a marked disease modifying effect on OA owing to IL-1 beta inhibition. diacerein 0-9 interleukin 1 beta Rattus norvegicus 95-104 23971039-10 2013 Both IL-1 beta (P < 0.001) and TNF- alpha (P < 0.001), were significantly decreased in NHAG-treated group. nhag 93-97 interleukin 1 beta Rattus norvegicus 5-14 23984371-8 2013 Water immersion restraint increased gastric mucosal ulcer and hemorrhage, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 levels but failed to affect mucosal lipid peroxidation and mucus secretion compared with non-WIR. Water 0-5 interleukin 1 beta Rattus norvegicus 109-131 23984371-9 2013 Sesamol significantly decreased gastric ulceration and hemorrhage and inhibited mucosal TNF-alpha, IL-1beta, and IL-6 production and NF-kappaB activity in WIR-treated rats. sesamol 0-7 interleukin 1 beta Rattus norvegicus 99-107 23218603-3 2013 Diacerein is an anthraquinone derivative with a marked disease modifying effect on OA owing to IL-1 beta inhibition. Anthraquinones 16-29 interleukin 1 beta Rattus norvegicus 95-104 23121415-10 2013 Betamethasone suppressed astrocyte activation and increases in TNF-alpha and IL-1beta levels in a rat model of neuropathic pain. Betamethasone 0-13 interleukin 1 beta Rattus norvegicus 77-85 23789867-5 2013 When rats were exposed to nano-TiO2 of 10 and 20 nm in diameter in 1.0 and 10.0 mg kg(-1), the concentrations IL-1beta, TNF-alpha and IL-10 in brain tissue increased with the dose of nano-TiO2. titanium dioxide 31-35 interleukin 1 beta Rattus norvegicus 110-118 24356372-13 2013 We also provide novel data that the interaction between NF-kappaB pathway and IL-1beta is important in the induction of DOX-induced inflammation and cytotoxicity in H9c2 cardiac cells. Doxorubicin 120-123 interleukin 1 beta Rattus norvegicus 78-86 24356372-8 2013 Importantly, the pretreatment with NaHS significantly attenuated the p38 MAPK/NF-kappaB pathway-mediated inflammatory responses induced by DOX, as evidenced by decreases in the levels of IL-1beta, IL-6 and TNF-alpha. sodium bisulfide 35-39 interleukin 1 beta Rattus norvegicus 187-195 24356372-8 2013 Importantly, the pretreatment with NaHS significantly attenuated the p38 MAPK/NF-kappaB pathway-mediated inflammatory responses induced by DOX, as evidenced by decreases in the levels of IL-1beta, IL-6 and TNF-alpha. Doxorubicin 139-142 interleukin 1 beta Rattus norvegicus 187-195 24356372-9 2013 In addition, application of NaHS or IL-1beta receptor antagonist (IL-1Ra) or PDTC (an inhibitor of NF-kappaB) attenuated the DOX-induced expression of iNOS and production of nitric oxide (NO), respectively. Doxorubicin 125-128 interleukin 1 beta Rattus norvegicus 36-44 24356372-9 2013 In addition, application of NaHS or IL-1beta receptor antagonist (IL-1Ra) or PDTC (an inhibitor of NF-kappaB) attenuated the DOX-induced expression of iNOS and production of nitric oxide (NO), respectively. Nitric Oxide 174-186 interleukin 1 beta Rattus norvegicus 36-44 22855292-8 2013 TNF-alpha, IL-1beta, and IL-6 were reduced at the protein and mRNA level in the TTA + DSS-group. 1-(carboxymethylthio)tetradecane 80-83 interleukin 1 beta Rattus norvegicus 11-19 23983461-3 2013 This study has evaluated minocycline influence on expression of Abeta protein, tau phosphorylation, and inflammatory cytokines (interleukin-1beta and tumor necrosis factor-alpha) in the brain of diabetic rats to clarify neuroprotection by minocycline under diabetic metabolic disorder. Minocycline 25-36 interleukin 1 beta Rattus norvegicus 128-145 23762140-6 2013 In addition, curcumin suppressed neuroinflammatory response by decreasing inflammatory mediators, such as IL-1 beta , TNF- alpha , PGE2, NO, COX-2, and iNOS induced by cerebral ischemia of rats. Curcumin 13-21 interleukin 1 beta Rattus norvegicus 106-115 24348690-4 2013 WSP-AbM administration markedly (P < 0.05) decreased serum IL-1 beta and TNF- alpha levels and the expressions of ICAM-1, COX-2, and iNOS NF- kappa B compared with OVX rats. abm 4-7 interleukin 1 beta Rattus norvegicus 62-71 23064810-10 2013 S-100beta release, edema volume and upregulation of IL-6 and IL-1beta expression were impeded by isoflurane. Isoflurane 97-107 interleukin 1 beta Rattus norvegicus 61-69 23737832-5 2013 Our results showed that cryptolepine significantly inhibited LPS-induced production of tumour necrosis factor-alpha (TNF alpha ), interleukin-6 (IL-6), interleukin-1beta (IL-1 beta ), nitric oxide, and PGE2. cryptolepine 24-36 interleukin 1 beta Rattus norvegicus 152-169 23737832-5 2013 Our results showed that cryptolepine significantly inhibited LPS-induced production of tumour necrosis factor-alpha (TNF alpha ), interleukin-6 (IL-6), interleukin-1beta (IL-1 beta ), nitric oxide, and PGE2. cryptolepine 24-36 interleukin 1 beta Rattus norvegicus 171-180 23689428-8 2013 RESULTS: 3 h after HI, an upregulation of the proinflammatory cytokines TNF-alpha and IL-1beta and anti-inflammatory IL-10 was observed in the ipsilateral hemisphere of the brain compared to mRNA levels in sham-operated animals. hi 19-21 interleukin 1 beta Rattus norvegicus 86-94 23689428-11 2013 Conversely, in the liver 3 h after HI, a downregulation of TNF-alpha, IL-1beta, and MCP-1 and a trend towards an upregulation of IL-10 were observed compared to mRNA levels of sham-operated animals. hi 35-37 interleukin 1 beta Rattus norvegicus 70-78 23533501-7 2013 Treatment with BCA or E2 prevented the OVX-induced increase in urinary deoxypyridinoline (DPD) and serum tumor necrosis factor alpha (TNF- alpha ) and interleukin-1 beta (IL-1 beta ). biochanin A 15-18 interleukin 1 beta Rattus norvegicus 151-169 23533501-7 2013 Treatment with BCA or E2 prevented the OVX-induced increase in urinary deoxypyridinoline (DPD) and serum tumor necrosis factor alpha (TNF- alpha ) and interleukin-1 beta (IL-1 beta ). biochanin A 15-18 interleukin 1 beta Rattus norvegicus 171-180 22855292-8 2013 TNF-alpha, IL-1beta, and IL-6 were reduced at the protein and mRNA level in the TTA + DSS-group. Dextran Sulfate 86-89 interleukin 1 beta Rattus norvegicus 11-19 23022406-4 2013 We found that stimulation of VSM cells with IL-1beta increased PKCdelta activity and intracellular ROS generation. Reactive Oxygen Species 99-102 interleukin 1 beta Rattus norvegicus 44-52 23022406-5 2013 SiRNA silencing of NOX4 but not NOX1 ablated the IL-1beta-dependent increase in ROS production. Reactive Oxygen Species 80-83 interleukin 1 beta Rattus norvegicus 49-57 23022406-8 2013 Taken together, these results indicate that IL-1beta-dependent activation of PKCdelta is modulated by NOX4-derived ROS. Reactive Oxygen Species 115-118 interleukin 1 beta Rattus norvegicus 44-52 23378761-10 2013 Gene-expression profile showed that cotreatment with RS to AlCl(3)-treated rats succeeded in exerting significant decreases in BACE1, AChE, and IL1B gene expression. Aluminum Chloride 59-66 interleukin 1 beta Rattus norvegicus 144-148 24223475-6 2013 Furthermore, scutellarin significantly reduced the expression of TLR4, NF- kappa B p65, TNF- alpha , IL-1 beta , IL-18, Bax and cleaved-caspase-3 p17, and increased the expression of Mcl1. scutellarin 13-24 interleukin 1 beta Rattus norvegicus 101-110 23089744-5 2013 P2RX7 and active IL-1beta, IL-18, and caspase-1 protein levels were markedly increased in the WKY nephritic glomeruli 4 days following induction of NTN, and the use of a P2RX7 antagonist reduced the levels of secreted active IL-1beta. imidacloprid 148-151 interleukin 1 beta Rattus norvegicus 17-25 21851230-6 2013 A high dose of estrogen (E2) or a low dose of progesterone (P1) increased brain levels of IL-1beta 52.7% and 79.2% respectively at 6 h after the TBI. Progesterone 46-58 interleukin 1 beta Rattus norvegicus 90-98 24522018-8 2013 We observed a correlation between CRF and IL-1beta mRNA levels in the citalopram-treated group of rats. Citalopram 70-80 interleukin 1 beta Rattus norvegicus 42-50 22991065-3 2013 The study of pro-inflammatory cytokines like IL-1beta, TNF-alpha, and IFN-gamma revealed their upregulation by DMBA administration and restoration of their levels toward normal by the treatment with etoricoxib, while the anti-inflammatory cytokine IL-2 was found to be down-regulated with carcinogen administration and corrected with etoricoxib treatment. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 111-115 interleukin 1 beta Rattus norvegicus 45-53 22991065-3 2013 The study of pro-inflammatory cytokines like IL-1beta, TNF-alpha, and IFN-gamma revealed their upregulation by DMBA administration and restoration of their levels toward normal by the treatment with etoricoxib, while the anti-inflammatory cytokine IL-2 was found to be down-regulated with carcinogen administration and corrected with etoricoxib treatment. Etoricoxib 199-209 interleukin 1 beta Rattus norvegicus 45-53 23147682-0 2013 Dietary beta-carotene regulates interleukin-1beta-induced expression of apolipoprotein E in astrocytes isolated from stroke-prone spontaneously hypertensive rats. beta Carotene 8-21 interleukin 1 beta Rattus norvegicus 32-49 24522018-10 2013 Citalopram administration inhibited the expression of TNF-alpha and IL-1beta transcripts in the hypothalamus, suggesting that selective serotonin reuptake inhibitors may be appropriate for PSD therapy. Citalopram 0-10 interleukin 1 beta Rattus norvegicus 68-76 23563031-10 2013 The protective effect of pioglitazone was accompanied by a fall in serum IL-1beta level. Pioglitazone 25-37 interleukin 1 beta Rattus norvegicus 73-81 23563031-12 2013 Suppression of IL-1beta could be another mechanism in pioglitazone-induced healing effect of gastric ulcers in cirrhotic rats. Pioglitazone 54-66 interleukin 1 beta Rattus norvegicus 15-23 23934460-7 2013 RESULTS: Fenofibrate administration significantly reduced serum total bilirubin, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, and tumor necrosis factor-alpha and interleukin-1beta levels. Fenofibrate 9-20 interleukin 1 beta Rattus norvegicus 221-238 24020812-0 2013 Gastrodin ameliorates anxiety-like behaviors and inhibits IL-1beta level and p38 MAPK phosphorylation of hippocampus in the rat model of posttraumatic stress disorder. gastrodin 0-9 interleukin 1 beta Rattus norvegicus 58-66 24020812-6 2013 However, repeated treatment with gastrodin, particularly at higher doses, reversed the aforementioned changes, including anxiety-like behavior, levels of IL-6 and IL-1beta, and the expression of iNOS and the p38 MAPK phosphorylation. gastrodin 33-42 interleukin 1 beta Rattus norvegicus 163-171 23469045-3 2013 In combination with carbachol (10 microM), rivastigmine (1 microM) significantly decreased the release of nitric oxide, TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-activated RAW 264.7 macrophages and this effect was abolished by alpha7 nicotinic receptor blockade by bungarotoxin. Carbachol 20-29 interleukin 1 beta Rattus norvegicus 131-139 23469045-3 2013 In combination with carbachol (10 microM), rivastigmine (1 microM) significantly decreased the release of nitric oxide, TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-activated RAW 264.7 macrophages and this effect was abolished by alpha7 nicotinic receptor blockade by bungarotoxin. Rivastigmine 43-55 interleukin 1 beta Rattus norvegicus 131-139 23437066-12 2013 Subsequently, these flavonoids inhibited the expression of tumor necrosis factor alpha, interleukin 1beta, intercellular adhesion molecule 1, matrix metallopeptidase 9, inducible nitric oxide synthase, and myeloperoxidase. Flavonoids 20-30 interleukin 1 beta Rattus norvegicus 88-140 23268791-20 2012 injection with ATL could significantly attenuate the expression of the mRNA of proinflammatory cytokines (IL-1beta and TNF-alpha) in the spinal cord in CIBP. cibp 152-156 interleukin 1 beta Rattus norvegicus 106-114 22648034-17 2013 IL-1beta and IL-10 were both significantly elevated by saline alone and their response was not prevented by IFN-gamma blockade. Sodium Chloride 55-61 interleukin 1 beta Rattus norvegicus 0-8 23548945-9 2013 Moreover, osthole treatment attenuated myeloperoxidase activity, monocyte/macrophage infiltration, and tumor necrosis factor-alpha, IL-1beta, and activated p38 mitogen-activated protein kinase expression in kidneys. osthol 10-17 interleukin 1 beta Rattus norvegicus 132-140 22902858-11 2012 Administration of docetaxel increased IL-1beta, COX-2, and POMC mRNA expression in the hypothalamus of rats. Docetaxel 18-27 interleukin 1 beta Rattus norvegicus 38-46 23197686-8 2012 Some oxidative stress and inflammatory markers (TNF-alpha, IL-6, ICAM-1, and IL1-beta) were upregulated in the retina of ZDF(fa/fa) and STZ diabetic rats after 4 months of disease. zdf 121-124 interleukin 1 beta Rattus norvegicus 77-85 23197686-8 2012 Some oxidative stress and inflammatory markers (TNF-alpha, IL-6, ICAM-1, and IL1-beta) were upregulated in the retina of ZDF(fa/fa) and STZ diabetic rats after 4 months of disease. Streptozocin 136-139 interleukin 1 beta Rattus norvegicus 77-85 22902858-0 2012 Involvement of hypothalamic cyclooxygenase-2, interleukin-1beta and melanocortin in the development of docetaxel-induced anorexia in rats. Docetaxel 103-112 interleukin 1 beta Rattus norvegicus 46-63 22902858-14 2012 These results suggest that IL-1beta and COX-2 mRNA expression and subsequent activation of POMC in the hypothalamus may contribute to the development of docetaxel-induced anorexia in rats. Docetaxel 153-162 interleukin 1 beta Rattus norvegicus 27-35 22940226-5 2012 At transcriptional level of inflammatory cytokine genes, guggulipid and nimesulide down regulated MPTP-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expressions with up regulations in interleukin-6 (IL-6) and interleukin-1alpha (IL-1alpha) mRNA expressions. guggulu extract 57-67 interleukin 1 beta Rattus norvegicus 155-172 23227940-13 2012 Functional analysis showed that miR-101 could aggravate chondrocyte ECM degradation, whereas miR-101 inhibition could reverse IL-1beta-induced ECM degradation. mir-101 93-100 interleukin 1 beta Rattus norvegicus 126-134 23227940-14 2012 CONCLUSION: miR-101 participates in IL-1beta-induced chondrocyte ECM degradation. mir-101 12-19 interleukin 1 beta Rattus norvegicus 36-44 23227940-15 2012 Down-regulating miR-101 expression can prevent the IL-1beta-induced ECM degradation in chondrocytes. mir-101 16-23 interleukin 1 beta Rattus norvegicus 51-59 22940226-5 2012 At transcriptional level of inflammatory cytokine genes, guggulipid and nimesulide down regulated MPTP-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expressions with up regulations in interleukin-6 (IL-6) and interleukin-1alpha (IL-1alpha) mRNA expressions. nimesulide 72-82 interleukin 1 beta Rattus norvegicus 155-172 22940226-5 2012 At transcriptional level of inflammatory cytokine genes, guggulipid and nimesulide down regulated MPTP-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expressions with up regulations in interleukin-6 (IL-6) and interleukin-1alpha (IL-1alpha) mRNA expressions. nimesulide 72-82 interleukin 1 beta Rattus norvegicus 174-182 22940226-5 2012 At transcriptional level of inflammatory cytokine genes, guggulipid and nimesulide down regulated MPTP-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expressions with up regulations in interleukin-6 (IL-6) and interleukin-1alpha (IL-1alpha) mRNA expressions. guggulu extract 57-67 interleukin 1 beta Rattus norvegicus 174-182 22940226-5 2012 At transcriptional level of inflammatory cytokine genes, guggulipid and nimesulide down regulated MPTP-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expressions with up regulations in interleukin-6 (IL-6) and interleukin-1alpha (IL-1alpha) mRNA expressions. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 98-102 interleukin 1 beta Rattus norvegicus 155-172 22940226-5 2012 At transcriptional level of inflammatory cytokine genes, guggulipid and nimesulide down regulated MPTP-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA expressions with up regulations in interleukin-6 (IL-6) and interleukin-1alpha (IL-1alpha) mRNA expressions. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 98-102 interleukin 1 beta Rattus norvegicus 174-182 22960133-7 2012 Also, Schisandrin B treated animal treatment abrogated protein expression of TNF-alpha and IL-1beta and degradation of MMP-2 and MMP-9 in ischemic hemispheres. schizandrin B 6-19 interleukin 1 beta Rattus norvegicus 91-99 23061565-8 2012 In addition, DSS-induced expression of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-1beta was significantly decreased. Dextran Sulfate 13-16 interleukin 1 beta Rattus norvegicus 92-100 22917079-6 2012 Because levels of interleukin (IL)-1beta were elevated in sera of pristane-injected rats, with levels mirroring the course of PIA, we examined the effect of pristane at single cell level in vitro, using rat splenocytes and the human monocytic cell line THP-1. pristane 66-74 interleukin 1 beta Rattus norvegicus 18-40 22917079-8 2012 The potassium channel inhibitor glibenclamide partly inhibited IL-1beta induction, suggesting involvement of the inflammasome. Glyburide 32-45 interleukin 1 beta Rattus norvegicus 63-71 22917079-11 2012 The higher serum IL-1beta levels in pristane-injected animals might be caused by both inflammasome-dependent and -independent mechanisms, such as passive release from dying-cells and probably extracellular maturation of pro-IL-1beta. pristane 36-44 interleukin 1 beta Rattus norvegicus 17-25 22917079-11 2012 The higher serum IL-1beta levels in pristane-injected animals might be caused by both inflammasome-dependent and -independent mechanisms, such as passive release from dying-cells and probably extracellular maturation of pro-IL-1beta. pristane 36-44 interleukin 1 beta Rattus norvegicus 224-232 22972308-0 2012 Minocycline and fluorocitrate suppress spinal nociceptive signaling in intrathecal IL-1beta-induced thermal hyperalgesic rats. Minocycline 0-11 interleukin 1 beta Rattus norvegicus 83-91 22972308-0 2012 Minocycline and fluorocitrate suppress spinal nociceptive signaling in intrathecal IL-1beta-induced thermal hyperalgesic rats. fluorocitrate 16-29 interleukin 1 beta Rattus norvegicus 83-91 22760256-3 2012 LIG significantly inhibited OVX-induced up-regulation of NF-kappaB activation and the production of IL-1beta, TNF-alpha, iNOS, ICAM-1 and COX-2. ovx 28-31 interleukin 1 beta Rattus norvegicus 100-108 22972308-3 2012 The effects of minocycline (20 mug), fluorocitrate (1 nmol), and SB203580 (5 mug) on IL-1beta (100 ng) treatment in rats were measured by nociceptive behaviors, western blotting of p38 mitogen-activated protein kinase (MAPK) and inducible nitric oxide synthase (iNOS) expression, cerebrospinal fluid nitric oxide (NO) levels, and immunohistochemical analyses. SB 203580 65-73 interleukin 1 beta Rattus norvegicus 85-93 22972308-6 2012 Minocycline, fluorocitrate, or SB203580 pretreatment suppressed this IL-1beta-upregulated P-p38 MAPK mainly in microglia and iNOS mainly in astrocytes; minocycline exhibited the most potent effect. Minocycline 0-11 interleukin 1 beta Rattus norvegicus 69-77 22972308-6 2012 Minocycline, fluorocitrate, or SB203580 pretreatment suppressed this IL-1beta-upregulated P-p38 MAPK mainly in microglia and iNOS mainly in astrocytes; minocycline exhibited the most potent effect. fluorocitrate 13-26 interleukin 1 beta Rattus norvegicus 69-77 22972308-6 2012 Minocycline, fluorocitrate, or SB203580 pretreatment suppressed this IL-1beta-upregulated P-p38 MAPK mainly in microglia and iNOS mainly in astrocytes; minocycline exhibited the most potent effect. SB 203580 31-39 interleukin 1 beta Rattus norvegicus 69-77 22972308-6 2012 Minocycline, fluorocitrate, or SB203580 pretreatment suppressed this IL-1beta-upregulated P-p38 MAPK mainly in microglia and iNOS mainly in astrocytes; minocycline exhibited the most potent effect. Minocycline 152-163 interleukin 1 beta Rattus norvegicus 69-77 22972308-7 2012 Minocycline and fluorocitrate pretreatment abrogated IL-1beta-induced NO release and thermal hyperalgesia in rats. Minocycline 0-11 interleukin 1 beta Rattus norvegicus 53-61 22972308-7 2012 Minocycline and fluorocitrate pretreatment abrogated IL-1beta-induced NO release and thermal hyperalgesia in rats. fluorocitrate 16-29 interleukin 1 beta Rattus norvegicus 53-61 22972308-8 2012 In conclusion, minocycline, fluorocitrate, and SB203580 effectively suppressed the IL-1beta-induced central sensitization and hyperalgesia in rats. Minocycline 15-26 interleukin 1 beta Rattus norvegicus 83-91 22972308-8 2012 In conclusion, minocycline, fluorocitrate, and SB203580 effectively suppressed the IL-1beta-induced central sensitization and hyperalgesia in rats. fluorocitrate 28-41 interleukin 1 beta Rattus norvegicus 83-91 22972308-8 2012 In conclusion, minocycline, fluorocitrate, and SB203580 effectively suppressed the IL-1beta-induced central sensitization and hyperalgesia in rats. SB 203580 47-55 interleukin 1 beta Rattus norvegicus 83-91 22806180-5 2012 While both drugs efficiently reduced the expression of iNOS and the release of nitric oxide, only FK506 strongly inhibited the expression of Cox-2 and secretion of the mature form of IL-1beta. Tacrolimus 98-103 interleukin 1 beta Rattus norvegicus 183-191 23116637-5 2012 OGD increased cell viability and release of TNF-alpha, IL-1beta, IL-6 and IL-8, these effects were suppressed by baicalin. baicalin 113-121 interleukin 1 beta Rattus norvegicus 55-63 22981168-0 2012 Aldosterone synergizes with peripheral inflammation to induce brain IL-1beta expression and depressive-like effects. Aldosterone 0-11 interleukin 1 beta Rattus norvegicus 68-76 22981168-9 2012 We found that aldosterone treatment increased LPS-induced IL-1beta mRNA expression in the PFC and CSF. Aldosterone 14-25 interleukin 1 beta Rattus norvegicus 58-66 22907416-12 2012 CONCLUSIONS: When compared directly, IL-1Ra loaded PF127 gel exhibited prolonged in vitro and in vivo release, greater efficacy to induce hypoglycemia and inhibited IL-1beta-stimulated production of IL-6 as compared to IL-1Ra aq. aq 226-228 interleukin 1 beta Rattus norvegicus 165-173 23147509-9 2012 Ibuprofen also significantly attenuated P3 HI-induced increases in brain cyclooxygenase 2 protein expression, interleukin-1beta, and tumor necrosis factor levels, as well as the increase in numbers of activated microglia. Ibuprofen 0-9 interleukin 1 beta Rattus norvegicus 110-127 23168994-5 2012 This study shows that GSK-3beta inhibition using a small-molecule inhibitor and the mood stabilizer lithium restores the IL-1beta-induced decrease in NSPC proliferation and neuronal differentiation of embryonic rat hippocampal NSPCs to control levels. Lithium 100-107 interleukin 1 beta Rattus norvegicus 121-129 23053967-7 2012 Ex-4 significantly inhibited the increase in LDH, CK, TNF-alpha, IL-1beta and MDA levels induced by high glucose, especially at the 1 and 10 nM concentrations as well as suppressed the decrease in SOD level. Glucose 105-112 interleukin 1 beta Rattus norvegicus 65-73 22422608-6 2012 The administration of 10 and 20 mg/kg GB could significantly (least-significant difference test: p < 0.05) suppress gene expressions of TLR-4 and NF-kappaB, lessen concentrations of tumour necrosis factor alpha, interleukin-1beta and interleukin-6, as well as reduce the number of apoptotic neuronal cells in traumatic rat brain tissues, but the administration of 5 mg/kg GB did not (p > 0.05). ginkgolide B 38-40 interleukin 1 beta Rattus norvegicus 215-232 23164507-2 2012 We have previously shown that IL-1beta expression is altered in the rat brain during a morphine tolerant state, indicating that this cytokine may serve as a convergent point between the immune challenge and opiate mediated biological pathways. Morphine 87-95 interleukin 1 beta Rattus norvegicus 30-38 22717997-5 2012 Hydroquinone treatment impaired LPS-induced nitric oxide (NO), tumour necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 secretions by neutrophils. hydroquinone 0-12 interleukin 1 beta Rattus norvegicus 105-127 23134577-0 2012 TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1beta-induced rat osteoarthritis chondrocytes in vitro. ferulic acid 94-109 interleukin 1 beta Rattus norvegicus 113-121 23134838-0 2012 Acetate supplementation reduces microglia activation and brain interleukin-1beta levels in a rat model of Lyme neuroborreliosis. Acetates 0-7 interleukin 1 beta Rattus norvegicus 63-80 23134838-8 2012 Further, acetate supplementation also reduced the expression of the pro-inflammatory cytokine IL-1beta by 2-fold as compared to controls. Acetates 9-16 interleukin 1 beta Rattus norvegicus 94-102 22221676-0 2012 Effects of physiological quercetin metabolites on interleukin-1beta-induced inducible NOS expression. Quercetin 25-34 interleukin 1 beta Rattus norvegicus 50-67 22995521-0 2012 Trafficking of endogenous smooth muscle cell cholesterol: a role for serum amyloid A and interleukin-1beta. Cholesterol 45-56 interleukin 1 beta Rattus norvegicus 89-106 22995521-8 2012 Interestingly, although neither tumor necrosis factor-alpha nor interferon-gamma induced cholesterol trafficking, interleukin-1beta induced [(14)C] cholesteryl ester accumulation that was also dependent upon sPLA(2) and sphingomyelinase activities. Cholesterol Esters 148-165 interleukin 1 beta Rattus norvegicus 114-131 22995521-9 2012 Serum amyloid A activates smooth muscle cell interleukin-1beta expression, and although the interleukin-1-receptor antagonist inhibited the interleukin-1beta-induced cholesterol trafficking, it had no effect on the movement of cholesterol mediated by serum amyloid A. Cholesterol 166-177 interleukin 1 beta Rattus norvegicus 140-157 23102243-6 2012 We estimated the effect of honey on serum levels and hepatic content of interleukin-1beta (IL-1beta) because the initial event in paracetamol-induced hepatotoxicity has been shown to be a toxic-metabolic injury that leads to hepatocyte death, activation of the innate immune response and upregulation of inflammatory cytokines. Acetaminophen 130-141 interleukin 1 beta Rattus norvegicus 72-89 23102243-6 2012 We estimated the effect of honey on serum levels and hepatic content of interleukin-1beta (IL-1beta) because the initial event in paracetamol-induced hepatotoxicity has been shown to be a toxic-metabolic injury that leads to hepatocyte death, activation of the innate immune response and upregulation of inflammatory cytokines. Acetaminophen 130-141 interleukin 1 beta Rattus norvegicus 91-99 23102243-7 2012 RESULTS: Paracetamol caused marked liver damage as noted by significant increased activities of serum AST and ALT as well as the level of Il-1beta. Acetaminophen 9-20 interleukin 1 beta Rattus norvegicus 138-146 23102243-8 2012 Paracetamol also resulted in a significant decrease in liver GSH content and GPx activity which paralleled an increase in Il-1beta and MDA levels. Acetaminophen 0-11 interleukin 1 beta Rattus norvegicus 122-130 23486342-0 2012 The lysine deacetylase inhibitor Givinostat inhibits beta-cell IL-1beta induced IL-1beta transcription and processing. givinostat 33-43 interleukin 1 beta Rattus norvegicus 63-71 23486342-0 2012 The lysine deacetylase inhibitor Givinostat inhibits beta-cell IL-1beta induced IL-1beta transcription and processing. givinostat 33-43 interleukin 1 beta Rattus norvegicus 80-88 24049647-8 2012 GdCl3 pre-treatment upregulated IL-1 beta , -2 and -10 pulmonary gene expression without significantly affecting the others. gadolinium chloride 0-5 interleukin 1 beta Rattus norvegicus 32-54 22221676-4 2012 Therefore, we investigated the effects of quercetin and its metabolites quercetin 3"-sulfate, quercetin 3-glucuronide and isorhamnetin 3-glucuronide on IL-1beta-stimulated iNOS gene expression in RINm5F beta-cells. Quercetin 42-51 interleukin 1 beta Rattus norvegicus 152-160 22221676-4 2012 Therefore, we investigated the effects of quercetin and its metabolites quercetin 3"-sulfate, quercetin 3-glucuronide and isorhamnetin 3-glucuronide on IL-1beta-stimulated iNOS gene expression in RINm5F beta-cells. quercetin 3'-sulfate 72-92 interleukin 1 beta Rattus norvegicus 152-160 22221676-4 2012 Therefore, we investigated the effects of quercetin and its metabolites quercetin 3"-sulfate, quercetin 3-glucuronide and isorhamnetin 3-glucuronide on IL-1beta-stimulated iNOS gene expression in RINm5F beta-cells. quercetin 3-O-glucuronide 94-117 interleukin 1 beta Rattus norvegicus 152-160 22221676-4 2012 Therefore, we investigated the effects of quercetin and its metabolites quercetin 3"-sulfate, quercetin 3-glucuronide and isorhamnetin 3-glucuronide on IL-1beta-stimulated iNOS gene expression in RINm5F beta-cells. Isorhamnetin 3-glucuronide 122-148 interleukin 1 beta Rattus norvegicus 152-160 22954523-4 2012 We hypothesized that pterostilbene would ameliorate the immediate inflammatory response in tumor necrosis factor alpha (TNF-alpha)-induced pancreatitis through downregulation of signal transducer and activator of transcription 3 (STAT3) and inhibition of TNF-alpha-induced secretion of lipase and proinflammatory cytokines interleukins (ILs) 1beta and 6. pterostilbene 21-34 interleukin 1 beta Rattus norvegicus 323-353 22954523-10 2012 Pterostilbene treatment inhibited TNF-alpha-induced secretion of lipase (P<0.01 and P<0.001), IL-1beta (P<0.05), and IL-6 (P<0.05 and P<0.01). pterostilbene 0-13 interleukin 1 beta Rattus norvegicus 100-108 22954523-12 2012 CONCLUSIONS: The dietary compound pterostilbene exerts an anti-inflammatory effect in pancreatitis through downregulation of STAT3 and decreased the secretion of lipase, IL-1beta, and IL-6. pterostilbene 34-47 interleukin 1 beta Rattus norvegicus 170-178 22959208-13 2012 Parecoxib inhibited hippocampal IL-1beta and TNF-alpha expression through downregulation of the COX-2/PGE2 pathway. parecoxib 0-9 interleukin 1 beta Rattus norvegicus 32-40 22221676-8 2012 Quercetin significantly reduced IL-1beta-induced nitrite production, iNOS protein and its mRNA expression levels, and it also inhibited IL-1beta-induced IkappaBalpha phosphorylation, NF-kappaB activation and iNOS promoter activity. Quercetin 0-9 interleukin 1 beta Rattus norvegicus 32-40 22221676-8 2012 Quercetin significantly reduced IL-1beta-induced nitrite production, iNOS protein and its mRNA expression levels, and it also inhibited IL-1beta-induced IkappaBalpha phosphorylation, NF-kappaB activation and iNOS promoter activity. Quercetin 0-9 interleukin 1 beta Rattus norvegicus 136-144 22221676-8 2012 Quercetin significantly reduced IL-1beta-induced nitrite production, iNOS protein and its mRNA expression levels, and it also inhibited IL-1beta-induced IkappaBalpha phosphorylation, NF-kappaB activation and iNOS promoter activity. Nitrites 49-56 interleukin 1 beta Rattus norvegicus 32-40 22221676-9 2012 Additionally, quercetin significantly restored the inhibition of insulin secretion by IL-1beta. Quercetin 14-23 interleukin 1 beta Rattus norvegicus 86-94 23000030-0 2012 Interleukin-1 beta simultaneously affects the stress and reproductive axes by modulating norepinephrine levels in different brain areas. Norepinephrine 89-103 interleukin 1 beta Rattus norvegicus 0-18 22890185-8 2012 Rebamipide reduced the expression of MMP-13, IL-1beta, HIF-2alpha, iNOS, and nitrotyrosine in OA cartilage in a dose-dependent manner. rebamipide 0-10 interleukin 1 beta Rattus norvegicus 45-53 22713680-10 2012 Moreover, chronic morphine infusion activated glial cells with an increase of proinflammatory cytokine tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 mRNA expression in morphine-tolerant rat spinal cords and these effects were suppressed by resveratrol pretreatment before the morphine challenge. Morphine 18-26 interleukin 1 beta Rattus norvegicus 132-149 22952117-6 2012 Exogenous PA augmented insulin-induced protection from interleukin-1beta-induced apoptosis. Phosphatidic Acids 10-12 interleukin 1 beta Rattus norvegicus 55-72 22904093-11 2012 In vivo, nicotine enhanced plasma levels of TLR7/8-mediated IL-6 and IL-1beta responses in prehypertensive SHRs but suppressed these responses in WKY rats. Nicotine 9-17 interleukin 1 beta Rattus norvegicus 69-77 22865118-9 2012 Treatment with 6-mp significantly reduced IL-1beta and TNF-alpha levels to those of the healthy control. Mercaptopurine 15-19 interleukin 1 beta Rattus norvegicus 42-50 22867973-4 2012 The aim of this study was to investigate the effect of exposure to ultrafine particles (UFP) during a single bout of forced exercise on the expression of inflammatory (IL1alpha, IL1beta, TNF, IL6, NOS2, NOS3) and oxidative stress (NFE2L2)-related genes, as well as BDNF in the brain of rats. ultrafine 67-76 interleukin 1 beta Rattus norvegicus 178-185 25538757-4 2012 The results of the enzyme-linked immunosorbent assay and the real-time quantitative PCR showed that the secretion and mRNA expression of the pro-inflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha were significantly decreased in the hippocampus and cerebral cortex of model rats treated with oxymatrine. oxymatrine 313-323 interleukin 1 beta Rattus norvegicus 168-217 22713680-10 2012 Moreover, chronic morphine infusion activated glial cells with an increase of proinflammatory cytokine tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 mRNA expression in morphine-tolerant rat spinal cords and these effects were suppressed by resveratrol pretreatment before the morphine challenge. Morphine 188-196 interleukin 1 beta Rattus norvegicus 132-149 22713680-10 2012 Moreover, chronic morphine infusion activated glial cells with an increase of proinflammatory cytokine tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 mRNA expression in morphine-tolerant rat spinal cords and these effects were suppressed by resveratrol pretreatment before the morphine challenge. Morphine 188-196 interleukin 1 beta Rattus norvegicus 132-149 23291590-8 2012 Pretreatment with beta-carotene decreased the total area of gastric ulcer and mRNA expression, as well as plasma levels of pro-inflammatory cytokines, IL-1beta and TNF-alpha, in a dose-dependent manner. beta Carotene 18-31 interleukin 1 beta Rattus norvegicus 151-159 22648072-4 2012 PFNA exposure dose-dependently increased absolute and relative liver weights, induced triglyceride accumulation, up-regulated the expression of both SERBP-1c and PPARalpha, and stimulated the release of TNFalpha and IL-1beta. perfluorononanoic acid 0-4 interleukin 1 beta Rattus norvegicus 216-224 22648072-6 2012 In vitro, PFNA-induced expression of PPARalpha in primary cultured hepatocytes was suppressed by recombinant rat TNFalpha and IL-1beta. perfluorononanoic acid 10-14 interleukin 1 beta Rattus norvegicus 126-134 22648072-9 2012 Our data demonstrate that TNFalpha and IL-1beta released from KCs following PFNA exposure can suppress the expression of PPARalpha via NF-kappaB pathway, which partially contribute to the evident accumulation of triglycerides in rat liver. Triglycerides 212-225 interleukin 1 beta Rattus norvegicus 39-47 22869351-4 2012 Positive correlations between the content of heptane-soluble diene conjugates and an area of necrosis, as well as between content carbonylated proteins and an area of necrosis, were found after injection of IL-1beta to unstressed rats. Heptanes 45-52 interleukin 1 beta Rattus norvegicus 207-215 22869351-4 2012 Positive correlations between the content of heptane-soluble diene conjugates and an area of necrosis, as well as between content carbonylated proteins and an area of necrosis, were found after injection of IL-1beta to unstressed rats. diene 61-66 interleukin 1 beta Rattus norvegicus 207-215 22869351-8 2012 Positive correlations between the level of circulating IL-1beta and necrosis areas, as well as between circulating IL-1beta and the content of heptane-soluble diene conjugates, were observed in stressed rats. Heptanes 143-150 interleukin 1 beta Rattus norvegicus 115-123 22869351-8 2012 Positive correlations between the level of circulating IL-1beta and necrosis areas, as well as between circulating IL-1beta and the content of heptane-soluble diene conjugates, were observed in stressed rats. diene 159-164 interleukin 1 beta Rattus norvegicus 115-123 23291590-10 2012 Our findings showed that the protective effect of beta-carotene may be mediated partly by reducing mRNA expression and plasma levels of IL-1beta and TNF-alpha, and concurrently, by increasing gene expression and plasma levels of the anti-inflammatory cytokine TGF-beta. beta Carotene 50-63 interleukin 1 beta Rattus norvegicus 136-144 22871953-6 2012 RESULTS: Tumor necrosis factor-alpha, interleukin-1beta, and myeloperoxidase levels decreased and antioxidant enzyme levels increased in the sevoflurane group compared with the control and isoflurane groups. Sevoflurane 141-152 interleukin 1 beta Rattus norvegicus 38-55 22710061-7 2012 An inhibitor of PKC, bisindolylmaleimide II (BIM), reversed phosphorylation, prevented elevation of nuclear c-Jun levels, and inhibited LPS-induced increases of IL-1beta and TNF-alpha mRNA"s induced by PLCdelta(1) knockdown. bisindolylmaleimide II 21-43 interleukin 1 beta Rattus norvegicus 161-169 22710061-7 2012 An inhibitor of PKC, bisindolylmaleimide II (BIM), reversed phosphorylation, prevented elevation of nuclear c-Jun levels, and inhibited LPS-induced increases of IL-1beta and TNF-alpha mRNA"s induced by PLCdelta(1) knockdown. bisindolylmaleimide II 45-48 interleukin 1 beta Rattus norvegicus 161-169 22706317-7 2012 IL-1beta induced the development of large colonies in the soft-agar as well as the formation of foci when IEC-18 cells were cultured in type-I collagen-coated plates. Agar 63-67 interleukin 1 beta Rattus norvegicus 0-8 22869019-8 2012 OGD increased cell viability and release of TNF-alpha, IL-1beta, IL-6, IL-8 and IL-10, these effects were suppressed by geniposide. geniposide 120-130 interleukin 1 beta Rattus norvegicus 55-63 23211305-15 2012 Administration of ADMA resulted in a significant decrease in the expression of SOD and GPx mRNAs and the up-regulation of mRNA for IL-1beta and TNF-alpha followed by an increase in these plasma cytokine levels as compared to respective values observed in vehicle-pretreated animals. N,N-dimethylarginine 18-22 interleukin 1 beta Rattus norvegicus 131-139 22836011-7 2012 The addition of APV or ifenprodil inhibited these enhanced responses, suggesting that LPS exposure stimulates IL-1beta release from astrocytes through a mechanism that requires NMDA receptor stimulation. apv 16-19 interleukin 1 beta Rattus norvegicus 110-118 22694660-8 2012 Isoproterenol enhanced the content of malondialdehyde (MDA), tumor necrosis-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and decreased the activities of superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH-Px) in left ventricles. Isoproterenol 0-13 interleukin 1 beta Rattus norvegicus 95-112 22694660-8 2012 Isoproterenol enhanced the content of malondialdehyde (MDA), tumor necrosis-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and decreased the activities of superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH-Px) in left ventricles. Isoproterenol 0-13 interleukin 1 beta Rattus norvegicus 114-122 22694660-11 2012 Ginsenoside Rh1 also partially inhibited the increase of MDA, TNF-alpha, IL-1beta contents and the decrease of SOD, catalase, and GSH-Px activities in left ventricles. ginsenoside Rh1 0-15 interleukin 1 beta Rattus norvegicus 73-81 22694660-12 2012 The results indicated that ginsenoside Rh1 possessed the effect against isoproterenol-induced cardiotoxicity, and that the mechanism of pharmacological action was related to regulating the activities of SOD, catalase, and GSH-Px and decreasing the contents of TNF-alpha and IL-1beta. ginsenoside Rh1 27-42 interleukin 1 beta Rattus norvegicus 274-282 22836011-7 2012 The addition of APV or ifenprodil inhibited these enhanced responses, suggesting that LPS exposure stimulates IL-1beta release from astrocytes through a mechanism that requires NMDA receptor stimulation. ifenprodil 23-33 interleukin 1 beta Rattus norvegicus 110-118 23492757-2 2012 This study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain IL-10 and IL-1beta after traumatic brain injury (TBI) in male rats. Ibuprofen 63-72 interleukin 1 beta Rattus norvegicus 107-115 22781706-8 2012 KEY FINDINGS: In comparison with the l-NAME group the silibinin treatment reduced the values of systolic blood pressure, proteinuria, TNF-alpha, IL-1beta and IFN-gamma in liver, normalized the platelet count and improved fetal outcomes. Silybin 54-63 interleukin 1 beta Rattus norvegicus 145-153 22781706-10 2012 Silibinin treatment induced attenuation of periportal inflammatory infiltrate, showing an association between inflammatory infiltrate and TNF-alpha, IL-1beta and IFN-gamma levels in liver homogenate. Silybin 0-9 interleukin 1 beta Rattus norvegicus 149-157 22854193-9 2012 Celastrol-treated rats showed a significant reduction in the levels of chemokines (RANTES, MCP-1, MIP-1alpha, and GRO/KC) as well as cytokines (TNF-alpha and IL-1beta) that induce them, compared to the vehicle-treated rats. celastrol 0-9 interleukin 1 beta Rattus norvegicus 158-166 22354681-8 2012 In addition, 15d-PGJ2 reduced the RA-induced release of TNF-alpha, IL-1beta and KC (p < 0.05) as well the expression of PKA and PKCepsilon (p < 0.05). 15-deoxy-delta(12,14)-prostaglandin J2 13-21 interleukin 1 beta Rattus norvegicus 67-75 22424886-7 2012 The short time ethanol administration also potentiated the periodontitis stimulatory effect on the mRNA expression of interleukin (IL)-1beta (p<0.01 and p<0.001, in semi-quantitative and real time PCR, respectively) and on the height of periodontal ligament (p<0.05). Ethanol 15-22 interleukin 1 beta Rattus norvegicus 118-140 22994521-5 2012 Immnofluorescence and quantitative PCR studies showed that concurrent treatment with the ET-A/B receptor antagonist, bosentan (200 mg/kg/day), blocked CH-induced ED-1+ macrophage invasion and the upregulation of cytokines, including interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha), and monocyte chemoattractant protein-1 (MCP-1). Bosentan 117-125 interleukin 1 beta Rattus norvegicus 233-250 22994521-5 2012 Immnofluorescence and quantitative PCR studies showed that concurrent treatment with the ET-A/B receptor antagonist, bosentan (200 mg/kg/day), blocked CH-induced ED-1+ macrophage invasion and the upregulation of cytokines, including interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha), and monocyte chemoattractant protein-1 (MCP-1). Bosentan 117-125 interleukin 1 beta Rattus norvegicus 252-260 22735354-9 2012 Furthermore, silibinin treatment significantly (P<0.01) decreased the genetic expression of biomarkers of the inflammatory response such as IL1beta, TNFalpha and their downstream target MMP7, all of them shown to be upregulated during colon carcinogenesis. Silybin 13-22 interleukin 1 beta Rattus norvegicus 143-150 23492757-2 2012 This study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain IL-10 and IL-1beta after traumatic brain injury (TBI) in male rats. Celecoxib 77-86 interleukin 1 beta Rattus norvegicus 107-115 23492757-7 2012 Brain IL-1beta decreased after treatment by ibuprofen or celecoxib (P< 0.001). Ibuprofen 44-53 interleukin 1 beta Rattus norvegicus 6-14 23492757-7 2012 Brain IL-1beta decreased after treatment by ibuprofen or celecoxib (P< 0.001). Celecoxib 57-66 interleukin 1 beta Rattus norvegicus 6-14 23492757-9 2012 Serum IL-1beta significantly decreased in rats that received celecoxib compared to TBI group (P< 0.01). Celecoxib 61-70 interleukin 1 beta Rattus norvegicus 6-14 22528462-10 2012 However, they decreased markedly after rat TG pretreatment with PD98059 (ERK1/2 inhibitor), SB203580 (P38 inhibitor), or SP600125 (JNK inhibitor) compared with rat TG co-culture with TNF-alpha or IL-1beta. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 64-71 interleukin 1 beta Rattus norvegicus 196-204 22528462-10 2012 However, they decreased markedly after rat TG pretreatment with PD98059 (ERK1/2 inhibitor), SB203580 (P38 inhibitor), or SP600125 (JNK inhibitor) compared with rat TG co-culture with TNF-alpha or IL-1beta. pyrazolanthrone 121-129 interleukin 1 beta Rattus norvegicus 196-204 22354081-9 2012 Animals treated with CCl(4) or SMN 100 showed an upregulation of IL-1beta, while animals in SMN 25 and SMN 50 groups showed a slight downregulation of expression of IL-1beta at the messenger RNA level. Cefaclor 21-24 interleukin 1 beta Rattus norvegicus 65-73 22354081-9 2012 Animals treated with CCl(4) or SMN 100 showed an upregulation of IL-1beta, while animals in SMN 25 and SMN 50 groups showed a slight downregulation of expression of IL-1beta at the messenger RNA level. Cefaclor 21-24 interleukin 1 beta Rattus norvegicus 165-173 22354081-9 2012 Animals treated with CCl(4) or SMN 100 showed an upregulation of IL-1beta, while animals in SMN 25 and SMN 50 groups showed a slight downregulation of expression of IL-1beta at the messenger RNA level. Silymarin 31-34 interleukin 1 beta Rattus norvegicus 65-73 22354081-10 2012 These findings suggest that SMN at higher dosage level might exert pro-oxidant effect as an increase in the level of MDA and proinflammatory mediators such as NO, and upregulation of IL-1beta in the hippocampus were shown. Silymarin 28-31 interleukin 1 beta Rattus norvegicus 183-191 22974604-7 2012 Curcumin treatments effectively attenuated the rats" pulmonary inflammation responses (as shown by reduced alveolar damage), decreased serum malondialdehyde and surfactant protein D levels, and inhibited the expressions of tumor necrosis factor alpha and interleukin-1beta. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 255-272 22311599-6 2012 Presynaptic release of glutamate with subsequent activation of NMDA receptors was necessary for IL-1beta-induced synapse loss. Glutamic Acid 23-32 interleukin 1 beta Rattus norvegicus 96-104 22220769-2 2012 The purpose of this study is to evaluate the effect of mono and combined BP clodronate and LDD therapies in reducing gingival levels of matrix metalloproteinase-9 (MMP-9), interleukin-1beta (IL-1beta), and alveolar bone loss in rats with diabetes. Clodronic Acid 76-86 interleukin 1 beta Rattus norvegicus 172-189 22220769-15 2012 The use of mono and combined clodronate and LDD administrations may significantly reduce levels of MMP-9 and IL-1beta expression. Clodronic Acid 29-39 interleukin 1 beta Rattus norvegicus 109-117 22922276-0 2012 Formononetin attenuates IL-1beta-induced apoptosis and NF-kappaB activation in INS-1 cells. formononetin 0-12 interleukin 1 beta Rattus norvegicus 24-32 22980653-1 2012 AIM: To determine the effects of glycyrrhetinic acid (GA), methotrexate(MTX) and GA+MTX on the expressions of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in fibroblast-like synovial (FLS) cells from collagen induced arthritis (CIA) rats. Methotrexate 59-71 interleukin 1 beta Rattus norvegicus 154-171 22980653-1 2012 AIM: To determine the effects of glycyrrhetinic acid (GA), methotrexate(MTX) and GA+MTX on the expressions of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in fibroblast-like synovial (FLS) cells from collagen induced arthritis (CIA) rats. Methotrexate 72-75 interleukin 1 beta Rattus norvegicus 154-171 22980653-1 2012 AIM: To determine the effects of glycyrrhetinic acid (GA), methotrexate(MTX) and GA+MTX on the expressions of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in fibroblast-like synovial (FLS) cells from collagen induced arthritis (CIA) rats. ga+mtx 81-87 interleukin 1 beta Rattus norvegicus 154-171 22980653-8 2012 CONCLUSION: GA, MTX, GA+MTX suppress the expression of TNF-alpha and IL-1beta in CIA-FLS cells in a time-dependent manner, and the suppressing effect is GA+MTX>MTX>GA. Methotrexate 16-19 interleukin 1 beta Rattus norvegicus 69-77 22980653-8 2012 CONCLUSION: GA, MTX, GA+MTX suppress the expression of TNF-alpha and IL-1beta in CIA-FLS cells in a time-dependent manner, and the suppressing effect is GA+MTX>MTX>GA. Glycyrrhetinic Acid 12-14 interleukin 1 beta Rattus norvegicus 69-77 22980653-8 2012 CONCLUSION: GA, MTX, GA+MTX suppress the expression of TNF-alpha and IL-1beta in CIA-FLS cells in a time-dependent manner, and the suppressing effect is GA+MTX>MTX>GA. Methotrexate 24-27 interleukin 1 beta Rattus norvegicus 69-77 22980653-8 2012 CONCLUSION: GA, MTX, GA+MTX suppress the expression of TNF-alpha and IL-1beta in CIA-FLS cells in a time-dependent manner, and the suppressing effect is GA+MTX>MTX>GA. Glycyrrhetinic Acid 21-23 interleukin 1 beta Rattus norvegicus 69-77 22980653-8 2012 CONCLUSION: GA, MTX, GA+MTX suppress the expression of TNF-alpha and IL-1beta in CIA-FLS cells in a time-dependent manner, and the suppressing effect is GA+MTX>MTX>GA. Methotrexate 24-27 interleukin 1 beta Rattus norvegicus 69-77 22980653-8 2012 CONCLUSION: GA, MTX, GA+MTX suppress the expression of TNF-alpha and IL-1beta in CIA-FLS cells in a time-dependent manner, and the suppressing effect is GA+MTX>MTX>GA. Methotrexate 24-27 interleukin 1 beta Rattus norvegicus 69-77 22750437-6 2012 RESULTS: Oxymatrine at 120mg/kg significantly suppressed gene expressions of TLR-4 and NF-kappaB, decreased levels of TNF-alpha, interleukin-1beta and interleukin-6, inhibited synthesis of 12/15-LOX, phospho-p38 MAPK and cPLA2 protein, and mitigated apoptotic neuronal changes following ICH in rat. oxymatrine 9-19 interleukin 1 beta Rattus norvegicus 129-146 22922276-6 2012 The aim of the present study was to assess possible in vitro effects of formononetin on cell apoptosis induced by IL-1beta in the rat insulinoma cell line, INS-1. formononetin 72-84 interleukin 1 beta Rattus norvegicus 114-122 22922276-7 2012 Our results demonstrate that formononetin significantly prevents IL-1beta-increased INS-1 cell death and blocks cytokine-induced apoptotic signaling (the reduction of Bax/Bcl-2 ratio and caspase-3 activity). formononetin 29-41 interleukin 1 beta Rattus norvegicus 65-73 22922276-9 2012 Our observations indicated that formononetin could protect against pancreatic beta-cell apoptosis caused by IL-1beta and therefore could be used in the future as a new drug improving diabetes mellitus. formononetin 32-44 interleukin 1 beta Rattus norvegicus 108-116 22882971-11 2012 CONCLUSIONS: In conclusion, non-crystalline silica particles in the nano- and submicro-size ranges seemed to induce IL-1beta release from LPS-primed RAW264.7 macrophages via similar mechanisms as crystalline silica, involving particle uptake, phagosomal leakage and activation of the NALP3 inflammasome. Silicon Dioxide 44-50 interleukin 1 beta Rattus norvegicus 116-124 22564261-3 2012 Thioacetamide (100 mg/kg, intraperitoneally) increased, within 12 h, hepatic serum aspartate transferase and alanine transferase levels, tumor necrosis factor-alpha production, interleukin-1beta and nitrite levels, and myeloperoxidase activity. Thioacetamide 0-13 interleukin 1 beta Rattus norvegicus 177-194 22564261-5 2012 In addition, FMO-competitive inhibitor methimazole reduced thioacetamide-induced myeloperoxidase activity, hepatic tumor necrosis factor-alpha, interleukin-1beta, nitrite, inducible nitric oxide synthase, and hepatic damage in thioacetamide-treated rats. Methimazole 39-50 interleukin 1 beta Rattus norvegicus 144-161 22882971-0 2012 Comparison of non-crystalline silica nanoparticles in IL-1beta release from macrophages. Silicon Dioxide 30-36 interleukin 1 beta Rattus norvegicus 54-62 22817663-7 2012 We observed significant up-regulation of pro-inflammatory molecules like nitric oxide, TNF-alpha, and IL-1beta when microglia were treated with Dichlorvos (10 muM). Dichlorvos 144-154 interleukin 1 beta Rattus norvegicus 102-110 22882971-12 2012 Notably, rat primary lung macrophages were more sensitive with respect to silica-induced IL-1beta release. Silicon Dioxide 74-80 interleukin 1 beta Rattus norvegicus 89-97 22882971-2 2012 Several reports have demonstrated that crystalline, but also non-crystalline silica particles induce IL-1beta release from macrophages via the NALP3-inflammasome complex (caspase-1, ASC and NALP3) in the presence of lipopolysaccharide (LPS) from bacteria. Silicon Dioxide 77-83 interleukin 1 beta Rattus norvegicus 101-109 22882971-13 2012 The differential response patterns obtained suggest that silica-induced IL-1beta responses not only depend on the particle surface area, but on factors and/or mechanisms such as particle reactivity or particle uptake. Silicon Dioxide 57-63 interleukin 1 beta Rattus norvegicus 72-80 22882971-3 2012 Our aim was to study the potential of different non-crystalline SiO2 particles from the nano- to submicro-sized range to activate IL-1beta responses in LPS-primed RAW264.7 macrophages and primary rat lung macrophages. Silicon Dioxide 64-68 interleukin 1 beta Rattus norvegicus 130-138 22621234-0 2012 Interleukin-1beta increases release of endothelin-1 and tumor necrosis factor as well as reactive oxygen species by peripheral leukocytes during experimental subarachnoid hemorrhage. Reactive Oxygen Species 89-112 interleukin 1 beta Rattus norvegicus 0-17 22882971-7 2012 In the lung macrophages, crystalline silica (MinUsil 5) induced IL-1beta release more potently than the non-crystalline Si50 and Si500, when adjusted to surface area. Silicon Dioxide 37-43 interleukin 1 beta Rattus norvegicus 64-72 22882971-7 2012 In the lung macrophages, crystalline silica (MinUsil 5) induced IL-1beta release more potently than the non-crystalline Si50 and Si500, when adjusted to surface area. minusil 45-52 interleukin 1 beta Rattus norvegicus 64-72 22882971-9 2012 The caspase-1 inhibitor zYVAD and RNA silencing of the NALP3 receptor reduced the particle-induced IL-1beta release in the RAW264.7 macrophages. zyvad 24-29 interleukin 1 beta Rattus norvegicus 99-107 22068917-11 2012 A combination of arginine and glutamine significantly decreased TNF-alpha and IL-1beta mRNA abundance in both the jejunum and ileum, while they also significantly decreased anti-inflammatory IL-10 in the ileum. Arginine 17-25 interleukin 1 beta Rattus norvegicus 78-86 22068917-11 2012 A combination of arginine and glutamine significantly decreased TNF-alpha and IL-1beta mRNA abundance in both the jejunum and ileum, while they also significantly decreased anti-inflammatory IL-10 in the ileum. Glutamine 30-39 interleukin 1 beta Rattus norvegicus 78-86 22327804-7 2012 Mi-64 significantly inhibited the overproduction of IL-1beta, IL-6, CINC-1, and TNF-alpha and augmented IL-10 production. mi-64 0-5 interleukin 1 beta Rattus norvegicus 52-60 22391294-11 2012 As compared with LR treatment, HTS-PTX resuscitation resulted in a 49% decrease in TNF-alpha, 29% decrease in IL-1beta, and 58% decrease in IL-6 in the shock model at 24h (p<0.05), and the respective decreases were 45, 24, and 35% in the sepsis model (p<0.05). Pentoxifylline 35-38 interleukin 1 beta Rattus norvegicus 110-118 22698911-13 2012 Serum tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and nitric oxide (NO) were decreased in the group treated with CCl(4) plus EVT. Cefaclor 140-143 interleukin 1 beta Rattus norvegicus 47-64 22698911-13 2012 Serum tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and nitric oxide (NO) were decreased in the group treated with CCl(4) plus EVT. Cefaclor 140-143 interleukin 1 beta Rattus norvegicus 66-74 22698911-13 2012 Serum tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and nitric oxide (NO) were decreased in the group treated with CCl(4) plus EVT. EVT 152-155 interleukin 1 beta Rattus norvegicus 47-64 22698911-13 2012 Serum tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and nitric oxide (NO) were decreased in the group treated with CCl(4) plus EVT. EVT 152-155 interleukin 1 beta Rattus norvegicus 66-74 22695743-5 2012 Oral administration with OLA decreased the production of IL-1beta, IL-6 and CINC-2alphabeta by resident macrophages and LNA decreased the production of IL-1beta, IL-6 and VEGF in the absence of lipopolysaccharide (LPS), although it accelerated IL-1beta release and decreased IL-10 synthesis when cells were stimulated with LPS. ola 25-28 interleukin 1 beta Rattus norvegicus 57-65 22846080-5 2012 The results showed that myricetin (especially at concentrations of 10 muM and 20 muM) increased cell viability and decreased cell apoptosis induced by the cytokine mixture of TNF-alpha (10 ng/mL), IL-1beta (5 ng/mL), and IFN-gamma (1000 IU/mL) for 3 days. myricetin 24-33 interleukin 1 beta Rattus norvegicus 197-205 22553216-1 2012 Carboxyamidotrizole (CAI) has been reported to suppress the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1beta and be effective in rats with adjuvant arthritis. carboxyamidotrizole 0-19 interleukin 1 beta Rattus norvegicus 118-140 22553216-1 2012 Carboxyamidotrizole (CAI) has been reported to suppress the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1beta and be effective in rats with adjuvant arthritis. Carboxyamidotriazole 21-24 interleukin 1 beta Rattus norvegicus 118-140 22553216-6 2012 CAI inhibited the production of TNF-alpha, IL-1beta, and IL-6 in serum, supernatant of peritoneal macrophages, and lamina propria. Carboxyamidotriazole 0-3 interleukin 1 beta Rattus norvegicus 43-51 22669728-7 2012 Piperine successfully reduced the level of proinflammatory cytokines IL-1beta, IL-6 and TNF-alpha, in ischemic group (p < 0.01). piperine 0-8 interleukin 1 beta Rattus norvegicus 69-77 22627682-7 2012 Stimulation with IL-1beta increased mRNA expression of DGKgamma, which was strongly attenuated by SB203580, a p38 MAPK inhibitor. SB 203580 98-106 interleukin 1 beta Rattus norvegicus 17-25 22704650-4 2012 With the porcine cartilage explant, IL-1beta induced release of sulfated-glycosaminoglycan (s-GAG) and hydroxyproline release, and this induction was significantly inhibited by sesamin. A73025 64-90 interleukin 1 beta Rattus norvegicus 36-44 22704650-4 2012 With the porcine cartilage explant, IL-1beta induced release of sulfated-glycosaminoglycan (s-GAG) and hydroxyproline release, and this induction was significantly inhibited by sesamin. Sulfur 58-59 interleukin 1 beta Rattus norvegicus 36-44 22704650-4 2012 With the porcine cartilage explant, IL-1beta induced release of sulfated-glycosaminoglycan (s-GAG) and hydroxyproline release, and this induction was significantly inhibited by sesamin. Glycosaminoglycans 94-97 interleukin 1 beta Rattus norvegicus 36-44 22704650-4 2012 With the porcine cartilage explant, IL-1beta induced release of sulfated-glycosaminoglycan (s-GAG) and hydroxyproline release, and this induction was significantly inhibited by sesamin. Hydroxyproline 103-117 interleukin 1 beta Rattus norvegicus 36-44 22484967-5 2012 Results showed that chronic hyperhomocysteinemia significantly increased pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6), chemokine CCL(2) (MCP-1) and prostaglandin E(2) in hippocampus and serum of rats at 1 and 12 h after the last injection of homocysteine. Homocysteine 33-45 interleukin 1 beta Rattus norvegicus 112-120 22695743-5 2012 Oral administration with OLA decreased the production of IL-1beta, IL-6 and CINC-2alphabeta by resident macrophages and LNA decreased the production of IL-1beta, IL-6 and VEGF in the absence of lipopolysaccharide (LPS), although it accelerated IL-1beta release and decreased IL-10 synthesis when cells were stimulated with LPS. ola 25-28 interleukin 1 beta Rattus norvegicus 152-160 22704650-4 2012 With the porcine cartilage explant, IL-1beta induced release of sulfated-glycosaminoglycan (s-GAG) and hydroxyproline release, and this induction was significantly inhibited by sesamin. sesamin 177-184 interleukin 1 beta Rattus norvegicus 36-44 22695743-5 2012 Oral administration with OLA decreased the production of IL-1beta, IL-6 and CINC-2alphabeta by resident macrophages and LNA decreased the production of IL-1beta, IL-6 and VEGF in the absence of lipopolysaccharide (LPS), although it accelerated IL-1beta release and decreased IL-10 synthesis when cells were stimulated with LPS. ola 25-28 interleukin 1 beta Rattus norvegicus 152-160 22698499-8 2012 However, the combined LIPUS with DMSO resulted in significantly lower levels of TNFalpha (2.2 times), IL-1beta (2.1 times), JNK phosphorylation (2.4 times), and NFkappaB (2.1 times). Dimethyl Sulfoxide 33-37 interleukin 1 beta Rattus norvegicus 102-110 22698499-9 2012 The results demonstrate that LIPUS associated with DMSO gel can attenuate TNFalpha, IL-1beta, NFkappaB protein levels and JNK phosphorylation in traumatic muscle injury. Dimethyl Sulfoxide 51-55 interleukin 1 beta Rattus norvegicus 84-92 22732404-0 2012 Rebamipide induces dendritic cell recruitment to N-methyl-N"-nitro-N-nitrosoguanidine (MNNG)-exposed rat gastric mucosa based on IL-1beta upregulation. rebamipide 0-10 interleukin 1 beta Rattus norvegicus 129-137 22941689-0 2012 [Effect of different CO2 pneumoperitoneum on IL-1beta and IL-6 in abdominal cavity]. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 21-24 interleukin 1 beta Rattus norvegicus 45-53 22941689-1 2012 OBJECTIVE: To evaluate the effect of different CO2 pneumoperitoneum on IL-1beta and IL-6 in abdominal cavity. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 47-50 interleukin 1 beta Rattus norvegicus 71-79 22941689-8 2012 With the increasing of duration and gas flow in CO2 pneumoperitoneum, the concentrations of IL-1beta and IL-6 in group C2 h, C3 h and C3f were higher than those in group C1 h (P<0.05). N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 48-51 interleukin 1 beta Rattus norvegicus 92-100 22732404-6 2012 Analysis of two chemotactic factors of dendritic cells, IL-1beta and TNF-alpha, in the gastric cancer cells showed that expression of IL-1beta, but not TNF-alpha, was induced by rebamipide in a dose-dependent manner. rebamipide 178-188 interleukin 1 beta Rattus norvegicus 56-64 22732404-0 2012 Rebamipide induces dendritic cell recruitment to N-methyl-N"-nitro-N-nitrosoguanidine (MNNG)-exposed rat gastric mucosa based on IL-1beta upregulation. Methylnitronitrosoguanidine 49-85 interleukin 1 beta Rattus norvegicus 129-137 22732404-6 2012 Analysis of two chemotactic factors of dendritic cells, IL-1beta and TNF-alpha, in the gastric cancer cells showed that expression of IL-1beta, but not TNF-alpha, was induced by rebamipide in a dose-dependent manner. rebamipide 178-188 interleukin 1 beta Rattus norvegicus 134-142 22732404-8 2012 In conclusion, rebamipide has potential tumor-suppressive effects on gastric tumorigenesis via the recruitment of dendritic cells, based on the upregulation of the IL-1beta gene in gastric epithelial cells. rebamipide 15-25 interleukin 1 beta Rattus norvegicus 164-172 22732404-0 2012 Rebamipide induces dendritic cell recruitment to N-methyl-N"-nitro-N-nitrosoguanidine (MNNG)-exposed rat gastric mucosa based on IL-1beta upregulation. Methylnitronitrosoguanidine 87-91 interleukin 1 beta Rattus norvegicus 129-137 22713471-0 2012 Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis. Nicotine 89-97 interleukin 1 beta Rattus norvegicus 101-118 22713471-4 2012 We aimed to investigate the effect of nicotine on IL-1beta-induced chondrocyte apoptosis and the mechanism underlying how nicotine antagonizes IL-1beta-induced apoptosis of rat chondrocytes. Nicotine 38-46 interleukin 1 beta Rattus norvegicus 50-58 22713471-4 2012 We aimed to investigate the effect of nicotine on IL-1beta-induced chondrocyte apoptosis and the mechanism underlying how nicotine antagonizes IL-1beta-induced apoptosis of rat chondrocytes. Nicotine 122-130 interleukin 1 beta Rattus norvegicus 143-151 22713471-8 2012 The results showed that nicotine neutralized the effect of IL-1beta on chondrocytes by activating PI3K/Akt signaling pathways, including the PI3K/Akt/Bcl-2 pathway, to block IL-1beta-induced cell apoptosis and the PI3K/Akt/p70S6K (p70S6 kinase)/S6 pathway for promoting protein synthesis, modulating its downstream effectors such as TIMP-1 and MMP-13. Nicotine 24-32 interleukin 1 beta Rattus norvegicus 59-67 22713471-8 2012 The results showed that nicotine neutralized the effect of IL-1beta on chondrocytes by activating PI3K/Akt signaling pathways, including the PI3K/Akt/Bcl-2 pathway, to block IL-1beta-induced cell apoptosis and the PI3K/Akt/p70S6K (p70S6 kinase)/S6 pathway for promoting protein synthesis, modulating its downstream effectors such as TIMP-1 and MMP-13. Nicotine 24-32 interleukin 1 beta Rattus norvegicus 174-182 22713471-9 2012 Activation of the PI3K/Akt pathway is, in part, required for the effect of nicotine on IL-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis. Nicotine 75-83 interleukin 1 beta Rattus norvegicus 87-95 22321167-4 2012 Inversely, the more severe elevations of hepatic water-soluble parts of TC and TG were found in the HFD+CS group, as the elevations of low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol in liver and serum, tumor necrosis factor-alpha, interleukin-1beta and malondialdehyde in liver. Water 49-54 interleukin 1 beta Rattus norvegicus 262-279 22426011-3 2012 The present study used fructose to induce hyperuricemia and dyslipidemia, which caused renal NLRP3 inflammasome activation characterized by over-expression of the NLRP3, apoptosis-associated speck-like protein (ASC) and caspase-1, resulting in overproduction of interleukin (IL)-1beta and IL-18, as well as IL-6 and tumor necrosis factor alpha (TNF-alpha) in rats. Fructose 23-31 interleukin 1 beta Rattus norvegicus 262-284 22320124-7 2012 The mRNA levels of TNF-alpha, IL-1beta and TNF-receptor type 1 were significantly reduced in GM + DXM and GM + MLT groups. gm + dxm 93-101 interleukin 1 beta Rattus norvegicus 30-38 22320124-7 2012 The mRNA levels of TNF-alpha, IL-1beta and TNF-receptor type 1 were significantly reduced in GM + DXM and GM + MLT groups. Gentamicins 93-97 interleukin 1 beta Rattus norvegicus 30-38 22529213-7 2012 CPA pretreatment enhanced IL-1beta- induced, but not TNF-alpha-induced, expression of chemokine (C-C motif) ligand 2, chemokine (C-X-C motif) ligand 1, inducible nitric oxide synthase, and Fas via augmented nuclear factor kappaB (NF-kappaB) activation. cyclopiazonic acid 0-3 interleukin 1 beta Rattus norvegicus 26-34 22529213-8 2012 X-box binding protein 1 (XBP1) and inositol-requiring enzyme 1, but not CCAAT/enhancer binding protein homologous protein, knockdown prevented the CPA-induced exacerbation of NF-kappaB-dependent genes and decreased IL-1beta-induced NF-kappaB promoter activity. cyclopiazonic acid 147-150 interleukin 1 beta Rattus norvegicus 215-223 22529213-10 2012 In conclusion, rat beta-cells facing mild ER stress are sensitized to IL-1beta, generating a more intense and protracted inflammatory response through inositol-requiring enzyme 1/XBP1 activation. Inositol 151-159 interleukin 1 beta Rattus norvegicus 70-78 22321167-4 2012 Inversely, the more severe elevations of hepatic water-soluble parts of TC and TG were found in the HFD+CS group, as the elevations of low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol in liver and serum, tumor necrosis factor-alpha, interleukin-1beta and malondialdehyde in liver. Cesium 104-106 interleukin 1 beta Rattus norvegicus 262-279 22564409-6 2012 Pretreatment with 15d-PGJ(2)-NC (100 and 1000 pg/TMJ), but not unloaded 15d-PGJ(2), was found to significantly decrease the release of IL-1beta cytokine and the animals" nociceptive behavioral response induced by intra-TMJ injection of formalin. 15d-pgj 18-25 interleukin 1 beta Rattus norvegicus 135-143 22738239-5 2012 It is suggested that because acute stressor exposure differentially increases IL-1beta levels within subcutaneous adipose relative to visceral adipose tissue in otherwise healthy, non-obese rats, repeated induction of this response may impair the ability of subcutaneous adipose tissue to uptake energy substrates, synthesize and retain triglycerides, and/or adapt to positive energy balance via hyperplasia. Triglycerides 337-350 interleukin 1 beta Rattus norvegicus 78-86 22784284-8 2012 The experimental results indicated that RSV significantly decreased oxidative stress (superoxide anion content, protein carbonyl level and Mn-SOD expression) in both tissues and hepatic inflammation (NF- kappaB and IL-1 beta ), but implicated proinflammatory potential of RSV in diabetic spleen (TNF-alpha and IL-6). Resveratrol 40-43 interleukin 1 beta Rattus norvegicus 215-224 22415536-7 2012 Both CCISE and CCITE groups demonstrated greater Hsp72 expression and lower TNF-alpha or IL-1beta level than did the CCI group in sciatic nerve on day 21 after CCI. ccise 5-10 interleukin 1 beta Rattus norvegicus 89-97 22676811-0 2012 Indomethacin protects rats from neuronal damage induced by traumatic brain injury and suppresses hippocampal IL-1beta release through the inhibition of Nogo-A expression. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 109-117 22676811-10 2012 More importantly, the TBI-associated stimulation in the levels of both Nogo-A and IL-1beta could be effectively inhibited by a specific Nogo-A antisense oligonucleotide. Oligonucleotides 153-168 interleukin 1 beta Rattus norvegicus 82-90 22676811-11 2012 CONCLUSIONS: Our findings suggest that the suppression of Nogo-A expression appears to be an early response conferred by indomethacin, which then leads to decreases in the levels of IL-1beta and TBI-induced neuron damage. Indomethacin 121-133 interleukin 1 beta Rattus norvegicus 182-190 22415536-7 2012 Both CCISE and CCITE groups demonstrated greater Hsp72 expression and lower TNF-alpha or IL-1beta level than did the CCI group in sciatic nerve on day 21 after CCI. ccite 15-20 interleukin 1 beta Rattus norvegicus 89-97 22415536-7 2012 Both CCISE and CCITE groups demonstrated greater Hsp72 expression and lower TNF-alpha or IL-1beta level than did the CCI group in sciatic nerve on day 21 after CCI. CCI 5-8 interleukin 1 beta Rattus norvegicus 89-97 22415536-7 2012 Both CCISE and CCITE groups demonstrated greater Hsp72 expression and lower TNF-alpha or IL-1beta level than did the CCI group in sciatic nerve on day 21 after CCI. CCI 15-18 interleukin 1 beta Rattus norvegicus 89-97 22821656-6 2012 RESULTS: Caf inhibited the production of NO, TNF-alpha and IL-1beta induced by LPS treatment in primary microglia in a dose-dependent manner. cafestol palmitate 9-12 interleukin 1 beta Rattus norvegicus 59-67 22821656-9 2012 Caf could also significantly inhibit the up-regulation of iNOS, TNF-alpha, and IL-1beta gene expressions in ischemic cerebral tissues. cafestol palmitate 0-3 interleukin 1 beta Rattus norvegicus 79-87 22103576-9 2012 In addition, kaerophyllin suppressed inflammation by reducing the mRNA of TNF-alpha, interleukin-1beta (IL-1beta) and monocyte chemoattractant protein-1 (MCP-1) genes. kaerophyllin 13-25 interleukin 1 beta Rattus norvegicus 85-102 22271414-12 2012 The mRNA expression and plasma levels of IL-1beta and TNF-alpha were significantly decreased in L-cysteine- and NaHS-treated rats in a dose-dependent manner. Cysteine 96-106 interleukin 1 beta Rattus norvegicus 41-49 22271414-12 2012 The mRNA expression and plasma levels of IL-1beta and TNF-alpha were significantly decreased in L-cysteine- and NaHS-treated rats in a dose-dependent manner. sodium bisulfide 112-116 interleukin 1 beta Rattus norvegicus 41-49 22103576-10 2012 In HSCs, kaerophyllin elevated PPAR-gamma activity and reduced TNF-alpha-stimulated mRNA levels of intracellular adhesion molecule-1 (ICAM-1), MCP-1 and IL-1beta genes, which were reversed by small interfering RNA knockdown of PPAR-gamma gene. kaerophyllin 9-21 interleukin 1 beta Rattus norvegicus 153-161 22103576-9 2012 In addition, kaerophyllin suppressed inflammation by reducing the mRNA of TNF-alpha, interleukin-1beta (IL-1beta) and monocyte chemoattractant protein-1 (MCP-1) genes. kaerophyllin 13-25 interleukin 1 beta Rattus norvegicus 104-112 21994254-9 2012 We found that pre-treatment with lithium 10 mM (but not 1 mM) significantly reduced LPS-induced secretion of TNF-alpha, IL1-beta, PGE(2) and NO. Lithium 33-40 interleukin 1 beta Rattus norvegicus 120-128 22969993-11 2012 However, PVAE administration significantly prevented IL-1beta-increased INS-1 cell death and LDH activity and attenuated IL-1beta-increased caspase-3 activity. pvae 9-13 interleukin 1 beta Rattus norvegicus 53-61 22969993-11 2012 However, PVAE administration significantly prevented IL-1beta-increased INS-1 cell death and LDH activity and attenuated IL-1beta-increased caspase-3 activity. pvae 9-13 interleukin 1 beta Rattus norvegicus 121-129 22969993-12 2012 Western blot data showed that PVAE also significantly attenuated IL-1beta-increased Fas, FasL and phospho-JNK levels in the INS-1 cells. ammonium ferrous sulfate 84-87 interleukin 1 beta Rattus norvegicus 65-73 22969993-13 2012 In addition, PVAE treatment significantly attenuated IL-1beta-increased NF-kappaB binding activity and prevented IL-1beta-increased TNF-alpha and IL-6 expression in INS-1 cells. pvae 13-17 interleukin 1 beta Rattus norvegicus 53-62 22969993-13 2012 In addition, PVAE treatment significantly attenuated IL-1beta-increased NF-kappaB binding activity and prevented IL-1beta-increased TNF-alpha and IL-6 expression in INS-1 cells. pvae 13-17 interleukin 1 beta Rattus norvegicus 53-61 21898269-7 2012 Pretreatment with CSEX also inhibited TNF-alpha, IL-1beta, VEGF-alpha, and IL-17A and blocked inflammation-related events (ICAM-1 and iNOS) by activation of NF-kappaB. csex 18-22 interleukin 1 beta Rattus norvegicus 49-57 22183481-4 2012 CIH increased CB TNF-alpha and IL-1beta and c-fos-positive neurons in the NTS, enhanced carotid chemosensory and ventilatory hypoxic responses, and produced hypertension. cih 0-3 interleukin 1 beta Rattus norvegicus 31-39 22454040-2 2012 The present study showed that 6 months treatment of 16 month old rats with ladostigil (1 mg/kg/day), a novel drug designed for the treatment of MCI, prevented the development of spatial memory deficits at 22 months of age and significantly decreased the gene expression of IL-1beta, IL-6, TNF-alpha and inducible nitric oxide synthase (iNOS) in the parietal cortex. (N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate 75-85 interleukin 1 beta Rattus norvegicus 273-281 21911049-9 2012 In addition, SS powder was revealed to modulate the equilibrium of T lymphocyte subsets, down-regulate TNF-alpha and IL-1beta, up-regulate IL-4 and IL-10, and significantly suppress the level of anti-CII antibody. H-SER-SER-OH 13-15 interleukin 1 beta Rattus norvegicus 117-125 22205542-9 2012 After 6 days of morphine treatment, cytokine (IL-1beta, IL-6) levels had significantly increased in serum; IL-1beta and IL-6 mRNA levels had significantly increased in the nucleus accumbens and medial prefrontal cortex, both addiction-related brain areas; and BDNF levels had significantly decreased, both in serum and in addiction-related brain areas. Morphine 16-24 interleukin 1 beta Rattus norvegicus 46-54 22205542-9 2012 After 6 days of morphine treatment, cytokine (IL-1beta, IL-6) levels had significantly increased in serum; IL-1beta and IL-6 mRNA levels had significantly increased in the nucleus accumbens and medial prefrontal cortex, both addiction-related brain areas; and BDNF levels had significantly decreased, both in serum and in addiction-related brain areas. Morphine 16-24 interleukin 1 beta Rattus norvegicus 107-115 22684568-10 2012 The results showed that METH could increase the microglia activation in the neuron-microglia cultures and elevate the secretion of IL-1beta and TNF-alpha, which could be attenuated by CD200-Fc. Methamphetamine 24-28 interleukin 1 beta Rattus norvegicus 131-139 22454040-4 2012 Ladostigil and its metabolites (10nM) also reduced TNF-alpha mRNA and protein by 25-35 % and IL-1beta and inducible nitric oxide synthase (iNOS) mRNA by 20-35 %. (N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate 0-10 interleukin 1 beta Rattus norvegicus 93-101 22820580-8 2012 DFA injection caused significantly decreased iron content in the brain tissue, reduced number of microglial cells, and lowered levels of IL-1beta and TNF-alpha. Deferoxamine 0-3 interleukin 1 beta Rattus norvegicus 137-145 22642771-0 2012 Telmisartan directly ameliorates the neuronal inflammatory response to IL-1beta partly through the JNK/c-Jun and NADPH oxidase pathways. Telmisartan 0-11 interleukin 1 beta Rattus norvegicus 71-79 22330755-4 2012 Overall, the treatment with carrageenan increased the effect of the intranigral injection of LPS on the loss of dopaminergic neurons in the SN along with all the other parameters studied, including: serum levels of the inflammatory markers TNF-alpha, IL-1beta, IL-6 and C-reactive protein; activation of microglia, expression of proinflammatory cytokines, the adhesion molecule ICAM and the enzyme iNOS, loss of astrocytes and damage to the blood brain barrier (BBB). Carrageenan 28-39 interleukin 1 beta Rattus norvegicus 251-259 22588836-9 2012 Furthermore, we found tanshinone IIA alone could also inhibit urate-induced MCP-1 and IL-1beta overexpression both in vivo and in vitro, accompanied with inhibition of NF-kappaB translocation from cytosome to nucleus. Uric Acid 62-67 interleukin 1 beta Rattus norvegicus 86-94 22642771-6 2012 Telmisartan reduced IL-1beta-induced cyclooxygenase-2 (COX-2) expression and PGE2 release more potently than did candesartan and losartan. Telmisartan 0-11 interleukin 1 beta Rattus norvegicus 20-28 22480513-7 2012 KEY FINDINGS: OKA caused memory-impairment in rats with increased expression of proinflammatory cytokine TNF-alpha and IL-1beta and total nitrite in brain regions hippocampus and cortex. Okadaic Acid 14-17 interleukin 1 beta Rattus norvegicus 119-127 22642771-6 2012 Telmisartan reduced IL-1beta-induced cyclooxygenase-2 (COX-2) expression and PGE2 release more potently than did candesartan and losartan. Dinoprostone 77-81 interleukin 1 beta Rattus norvegicus 20-28 22642771-6 2012 Telmisartan reduced IL-1beta-induced cyclooxygenase-2 (COX-2) expression and PGE2 release more potently than did candesartan and losartan. candesartan 113-124 interleukin 1 beta Rattus norvegicus 20-28 22642771-7 2012 Telmisartan reduced the IL-1beta-induced increase in IL-1R1 receptor and NADPH oxidase-4 (NOX-4) mRNA expression, NADPH oxidase activity, and ROS generation, and reduced hydrogen peroxide-induced COX-2 gene expression. Telmisartan 0-11 interleukin 1 beta Rattus norvegicus 24-32 22642771-7 2012 Telmisartan reduced the IL-1beta-induced increase in IL-1R1 receptor and NADPH oxidase-4 (NOX-4) mRNA expression, NADPH oxidase activity, and ROS generation, and reduced hydrogen peroxide-induced COX-2 gene expression. Reactive Oxygen Species 142-145 interleukin 1 beta Rattus norvegicus 24-32 22642771-7 2012 Telmisartan reduced the IL-1beta-induced increase in IL-1R1 receptor and NADPH oxidase-4 (NOX-4) mRNA expression, NADPH oxidase activity, and ROS generation, and reduced hydrogen peroxide-induced COX-2 gene expression. Hydrogen Peroxide 170-187 interleukin 1 beta Rattus norvegicus 24-32 22642771-8 2012 Telmisartan did not modify IL-1beta-induced ERK1/2 and p38 mitogen-activated protein kinase (MAPK) phosphorylation or nuclear factor-kappaB activation but significantly decreased IL-1beta-induced c-Jun N-terminal kinase (JNK) and c-Jun activation. Telmisartan 0-11 interleukin 1 beta Rattus norvegicus 179-187 22642771-9 2012 The JNK inhibitor SP600125 decreased IL-1beta-induced PGE2 release with a potency similar to that of telmisartan. pyrazolanthrone 18-26 interleukin 1 beta Rattus norvegicus 37-45 22642771-9 2012 The JNK inhibitor SP600125 decreased IL-1beta-induced PGE2 release with a potency similar to that of telmisartan. Dinoprostone 54-58 interleukin 1 beta Rattus norvegicus 37-45 22642771-10 2012 The PPARgamma agonist pioglitazone reduced IL-1beta-induced inflammatory reaction, whereas telmisartan did not activate PPARgamma, as shown by its failure to enhance the expression of the PPARgamma target genes ABCG1 and CD36, and the inability of the PPARgamma antagonists GW9662 and T0070907 to modify the effect of telmisartan on COX-2 induction. Pioglitazone 22-34 interleukin 1 beta Rattus norvegicus 43-51 22642771-11 2012 The effect of telmisartan on IL-1beta-stimulated COX-2 and IL-1R1 mRNA expression and ROS production was replicated in primary rat cortical neurons. Telmisartan 14-25 interleukin 1 beta Rattus norvegicus 29-37 22642771-11 2012 The effect of telmisartan on IL-1beta-stimulated COX-2 and IL-1R1 mRNA expression and ROS production was replicated in primary rat cortical neurons. Reactive Oxygen Species 86-89 interleukin 1 beta Rattus norvegicus 29-37 22642771-12 2012 CONCLUSIONS: Telmisartan directly ameliorates IL-1beta-induced neuronal inflammatory response by inhibition of oxidative stress and the JNK/c-Jun pathway. Telmisartan 13-24 interleukin 1 beta Rattus norvegicus 46-54 21409386-7 2012 Moreover, taurine significantly reduced the levels of tumor necrosis factor-alpha, interleukin-1beta, inducible nitric oxide synthase, and intracellular adhesion molecule-1, lessened the activities of myeloperoxidase and attenuated the infiltration of neutrophils in the penumbra and core at 22 h of reperfusion. Taurine 10-17 interleukin 1 beta Rattus norvegicus 83-100 22401764-10 2012 The in vitro data showed that puerarin inhibited the production of IL-1beta, TNF-alpha, IL-6, PGE(2) and NO; moreover, the RT-PCR analysis and the western blot analysis indicated that puerarin regulated the transcriptional level via suppression of NF-kappaB activation and blockade of MAPK signal pathway. puerarin 30-38 interleukin 1 beta Rattus norvegicus 67-75 22076633-0 2012 Identification of two new arthritis severity loci that regulate levels of autoantibodies, interleukin-1beta, and joint damage in pristane- and collagen-induced arthritis. pristane 129-137 interleukin 1 beta Rattus norvegicus 90-107 22465472-6 2012 In rats, SM induced a burst of pro-inflammatory cytokines/chemokines within 72 h, including IL-1beta, TNF-alpha, IL-2, IL-6, CCL2, CCL3, CCL11, and CXCL1 that was associated with neutrophilic infiltration into the lung. Mustard Gas 9-11 interleukin 1 beta Rattus norvegicus 92-100 22337285-10 2012 Furthermore, EA or AM1241 treatment significantly decreased the mRNA and protein levels of IL-1beta, IL-6 and TNF-alpha in inflamed skin tissues. AM 1241 19-25 interleukin 1 beta Rattus norvegicus 91-99 22406435-7 2012 U46619 inhibited IL-1beta-induced cyclic GMP production, and the inhibition was partially prevented by superoxide dismutase. Cyclic GMP 34-44 interleukin 1 beta Rattus norvegicus 17-25 21966942-7 2012 Moreover, in gingival tissue sampled 3 days after ligature attachment, fluoxetine administration reduced IL-1beta and COX-2 mRNA expression. Fluoxetine 71-81 interleukin 1 beta Rattus norvegicus 105-113 22578573-2 2012 Our aim was to investigate the acute effects of Interleukin-1beta (IL-1beta) and Interferon-gamma (IFN-gamma) on glucose-induced insulin secretion in normal lean sand rats maintained on their natural diet and in obese insulin resistant normoglycemic or type 2 diabetic animals after a 9-month high caloric diet. Glucose 113-120 interleukin 1 beta Rattus norvegicus 48-65 22534700-6 2012 RESULTS: Induction of ulcers by cysteamine was accompanied by a reduction in duodenal blood flow, mucosal DNA synthesis and mucosal activity of superoxide dismutase (SOD); whereas mucosal concentration of interleukin-1beta and malonyldialdehyde (MDA - an index of lipid peroxidation) were increased. Cysteamine 32-42 interleukin 1 beta Rattus norvegicus 205-222 22234378-9 2012 Only female rats treated with olanzapine (2 mg/kg) had elevated plasma levels of IL-8 and IL-1beta, while both males and females had olanzapine-induced increases in adiposity and evidence of macrophage infiltration into adipose tissue. Olanzapine 30-40 interleukin 1 beta Rattus norvegicus 90-98 22450316-7 2012 Inhibition of JNK with SP600125 (a JNK inhibitor) decreased the expression of TNFalpha and IL-1beta. pyrazolanthrone 23-31 interleukin 1 beta Rattus norvegicus 91-99 22426481-9 2012 The in vivo protective effect of EGCG was tested by measuring testicular levels of TNF-alpha, IL-6 and IL-1beta by ELISA and mRNA expression of iNOS, MCP-1, p53, Bax, Bcl-2 and survivin by real-time PCR. epigallocatechin gallate 33-37 interleukin 1 beta Rattus norvegicus 103-111 22298642-5 2012 Treatment with losartan significantly attenuated TAC-induced cardiac hypertrophy, in parallel with decreased expression of RANKL, TNF-alpha, IL-1alpha, and IL-1beta. Losartan 15-23 interleukin 1 beta Rattus norvegicus 156-164 22781577-16 2012 The pancreatic expressions of TNF-alpha mRNA, IL-1beta mRNA, ICAM-1 mRNA, E-selectin mRNA and NF-kappaB p65 mRNA at 12 h and 24 h decreased in the LXA(4)-ME group versus the AP group at the corresponding time points (all P < 0.01)while the expression of IL-10 mRNA increased versus the AP group at the corresponding time points (all P < 0.01). lipoxin A4 methyl ester 147-156 interleukin 1 beta Rattus norvegicus 46-54 22340139-5 2012 Inhibition of 5alpha-reductase (an allopregnanolone-synthesising enzyme) with finasteride potentiated IL-1beta-evoked oxytocin secretion in late pregnant rats, whereas allopregnanolone reduced the oxytocin response in virgin rats. Finasteride 78-89 interleukin 1 beta Rattus norvegicus 102-110 22246136-10 2012 Furthermore, resveratrol treatment significantly attenuated the TLR4 expression, inhibited NF-kappaB activation and reduced the levels of tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta caused by A/R injury in the culture medium. Resveratrol 13-24 interleukin 1 beta Rattus norvegicus 176-198 22528236-4 2012 CIBP rats showed significant activation of microglia and astrocytes, and also up-regulation of phosphorylated p38 mitogen-activated protein kinase (p38 MAPK) and pro-inflammatory mediators released by glial cells (IL-1beta, IL-6, TNF-alpha and brain-derived neurotrophic factor) in the RVM. cibp 0-4 interleukin 1 beta Rattus norvegicus 214-222 22340139-4 2012 In the present study, we tested whether allopregnanolone induces opioid inhibition of the oxytocin system in response to IL-1beta in late pregnancy. Pregnanolone 40-56 interleukin 1 beta Rattus norvegicus 121-129 22340139-7 2012 In immunoreactive oxytocin neurones in the SON and PVN, finasteride increased IL-1beta-induced Fos expression in pregnant rats. Finasteride 56-67 interleukin 1 beta Rattus norvegicus 78-86 22340139-8 2012 Conversely, allopregnanolone reduced the number of magnocellular oxytocin neurones activated by IL-1beta in virgin rats. Pregnanolone 12-28 interleukin 1 beta Rattus norvegicus 96-104 22340139-9 2012 Treatment with naloxone (an opioid antagonist) greatly enhanced the oxytocin response to IL-1beta in pregnancy, and finasteride did not enhance this effect, indicating that allopregnanolone and the endogenous opioid mechanisms do not act independently. Naloxone 15-23 interleukin 1 beta Rattus norvegicus 89-97 22340139-10 2012 Indeed, allopregnanolone induced opioid inhibition over oxytocin responses to IL-1beta in virgin rats. Pregnanolone 8-24 interleukin 1 beta Rattus norvegicus 78-86 22466130-13 2012 Injection of IL-1beta (120 fmol) into the RVM induced behavioral hyperalgesia, which was blocked by RS-102895 (10 pmol). RS 102895 100-109 interleukin 1 beta Rattus norvegicus 13-21 22201038-10 2012 administration of low doses of AM251 per se significantly decreased both pain related behavior and spinal IL1-beta expression in formalin test. Formaldehyde 129-137 interleukin 1 beta Rattus norvegicus 106-114 22427156-0 2012 Interleukin-1beta causes fluoxetine resistance in an animal model of epilepsy-associated depression. Fluoxetine 25-35 interleukin 1 beta Rattus norvegicus 0-17 22342823-11 2012 Astragaloside IV exerts the protection through remarkably decreasing the percentage of CD11b/CD18-positive neutrophils and down-regulating the expression of intercellular adhesion molecule-1 (ICAM-1), which is partly achieved by strongly attenuating the production of TNF-alpha and IL-1beta and inhibiting level of nuclear factor-kappaB (NF-kappaB). astragaloside A 0-16 interleukin 1 beta Rattus norvegicus 282-290 22561570-7 2012 The IL-1beta in blood and the cerebrospinal fluid of rats in the highdose TSA group was lower than that in control and DMSO groups (P<0.05); for the low-dose TSA group IL-1beta levels were statistically the same as in controls. trichostatin A 74-77 interleukin 1 beta Rattus norvegicus 4-12 22561570-7 2012 The IL-1beta in blood and the cerebrospinal fluid of rats in the highdose TSA group was lower than that in control and DMSO groups (P<0.05); for the low-dose TSA group IL-1beta levels were statistically the same as in controls. trichostatin A 161-164 interleukin 1 beta Rattus norvegicus 4-12 22561570-7 2012 The IL-1beta in blood and the cerebrospinal fluid of rats in the highdose TSA group was lower than that in control and DMSO groups (P<0.05); for the low-dose TSA group IL-1beta levels were statistically the same as in controls. trichostatin A 161-164 interleukin 1 beta Rattus norvegicus 171-179 22574283-4 2012 AM1241 produced profound anti-allodynia with corresponding immunoreactive levels of p38 mitogen-activated kinase, IL-1beta, IL-10, the endocannabinoid enzyme monoacylglycerol lipase, and astrocyte activation markers that were similar to nonneuropathic controls. AM 1241 0-6 interleukin 1 beta Rattus norvegicus 114-122 22561570-10 2012 CONCLUSION: High-dose TSA preconditioning reduces cerebral infarction volume and decreases IL- 1beta levels in blood and cerebrospinal fluid; age does not affect these parameters. trichostatin A 22-25 interleukin 1 beta Rattus norvegicus 91-100 21806470-6 2012 Treatment of injured rats with sulforaphane, an activator of Nrf2/ARE signaling, significantly increased levels of Nrf2 and glutamate-cysteine ligase (GCL), a rate-limiting enzyme for synthesis of glutathione, and decreased levels of inflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) thus leading to a reduction in contusion volume and improvement in coordination. sulforaphane 31-43 interleukin 1 beta Rattus norvegicus 258-275 21806470-6 2012 Treatment of injured rats with sulforaphane, an activator of Nrf2/ARE signaling, significantly increased levels of Nrf2 and glutamate-cysteine ligase (GCL), a rate-limiting enzyme for synthesis of glutathione, and decreased levels of inflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) thus leading to a reduction in contusion volume and improvement in coordination. sulforaphane 31-43 interleukin 1 beta Rattus norvegicus 277-285 22413888-0 2012 Acetate supplementation modulates brain histone acetylation and decreases interleukin-1beta expression in a rat model of neuroinflammation. Acetates 0-7 interleukin 1 beta Rattus norvegicus 74-91 22413888-4 2012 METHODS: In this study, we examined the effect of a 28-day-dosing regimen of glyceryl triacetate, to induce acetate supplementation, on brain histone acetylation and interleukin-1beta expression in a rat model of lipopolysaccharide-induced neuroinflammation. Triacetin 77-96 interleukin 1 beta Rattus norvegicus 166-183 22413888-4 2012 METHODS: In this study, we examined the effect of a 28-day-dosing regimen of glyceryl triacetate, to induce acetate supplementation, on brain histone acetylation and interleukin-1beta expression in a rat model of lipopolysaccharide-induced neuroinflammation. Acetates 89-96 interleukin 1 beta Rattus norvegicus 166-183 22281447-8 2012 Hence, it was concluded that curcumin is of potent therapeutic value in the amelioration of alcoholic neuropathy in rats and acts by inhibition of pro-inflammatory mediators like TNF-alpha and IL-1beta. Curcumin 29-37 interleukin 1 beta Rattus norvegicus 193-201 22236721-6 2012 Further, arsenic enhanced cyclooxygenase-1 and cyclooxygenase-2 activities and tumor necrosis factor-alpha, interleukin-1beta and prostaglandin-E(2) production in hind paw muscle. Arsenic 9-16 interleukin 1 beta Rattus norvegicus 108-125 22236721-8 2012 This may relate to arsenic-mediated local release of tumor necrosis factor-alpha and interleukin-1beta, which causes cyclooxygenase induction and consequent prostaglandin-E(2) release. Arsenic 19-26 interleukin 1 beta Rattus norvegicus 85-102 22236721-8 2012 This may relate to arsenic-mediated local release of tumor necrosis factor-alpha and interleukin-1beta, which causes cyclooxygenase induction and consequent prostaglandin-E(2) release. Prostaglandins E 157-172 interleukin 1 beta Rattus norvegicus 85-102 21806470-6 2012 Treatment of injured rats with sulforaphane, an activator of Nrf2/ARE signaling, significantly increased levels of Nrf2 and glutamate-cysteine ligase (GCL), a rate-limiting enzyme for synthesis of glutathione, and decreased levels of inflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) thus leading to a reduction in contusion volume and improvement in coordination. Glutathione 197-208 interleukin 1 beta Rattus norvegicus 258-275 21806470-6 2012 Treatment of injured rats with sulforaphane, an activator of Nrf2/ARE signaling, significantly increased levels of Nrf2 and glutamate-cysteine ligase (GCL), a rate-limiting enzyme for synthesis of glutathione, and decreased levels of inflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) thus leading to a reduction in contusion volume and improvement in coordination. Glutathione 197-208 interleukin 1 beta Rattus norvegicus 277-285 21915762-2 2012 The overproduction of nitrogen species derived from inducible nitric oxide synthase (iNOS), its enzyme, and interleukine-1 beta (IL-1beta), and inflammatory cytokine have been implicated in immune responses. Nitrogen 22-30 interleukin 1 beta Rattus norvegicus 129-137 22023455-8 2012 The B(1) R antagonist also reversed the enhancing effect of glucose feeding on whole body and epididymal fat mass and on the expression of macrophage CD68, interleukin-1beta, tumour necrosis factor-alpha and inducible nitric oxide synthase in retroperitoneal adipose tissue. Glucose 60-67 interleukin 1 beta Rattus norvegicus 156-203 22183812-9 2012 Moreover, treatment of isolated liver cells with melanocortin agonists (alpha-MSH and THIQ) inhibited the endotoxin-induced upregulation of the acute-phase cytokine (IL-6, IL1beta and TNF-alpha) gene expression in Kupffer cells and of chemokine gene expression in hepatocytes. 1,2,3,4-tetrahydroisoquinoline 86-90 interleukin 1 beta Rattus norvegicus 172-179 22138247-5 2012 Both doses of DAS suppressed endotoxin-induced neutrophilia, serum levels of sICAM-1 and CINC-1, cellular CD11b on neutrophils, and intestinal contents of ICAM-1, CINC-1, TNF-alpha, and IL-1beta (p<0.05). allyl sulfide 14-17 interleukin 1 beta Rattus norvegicus 186-194 22138247-6 2012 DADS suppressed endotoxin-induced intestinal contents of ICAM-1, TNF-alpha, and IL-1beta at both doses, but only suppressed the serum sICAM-1 level and cellular CD11b on neutrophils at the low dose (p<0.05). diallyl disulfide 0-4 interleukin 1 beta Rattus norvegicus 80-88 22138247-7 2012 DATS did not ameliorate the endotoxin-induced serum level of sICAM-1 or CINC-1 but suppressed intestinal IL-1beta at both doses. diallyl trisulfide 0-4 interleukin 1 beta Rattus norvegicus 105-113 22031851-4 2012 We hypothesized that curcumin, by blocking the inflammatory mediators TNF-alpha and IL-1beta, could also reduce cyclooxygenase (COX) and phospholipase expression in the kidney. Curcumin 21-29 interleukin 1 beta Rattus norvegicus 84-92 22239125-7 2012 Sirolimus was associated with a reduction in plasma interleukin (IL)-1beta and tumour necrosis factor (TNF)-alpha and higher levels of catalase and total antioxidant status. Sirolimus 0-9 interleukin 1 beta Rattus norvegicus 52-74 22363136-18 2012 SKLB010 inhibited the activation of NF-kappaB by suppressing the degradation of IkappaB, and prevented the secretion of pro-inflammatory mediators such as tumor necrosis factor-alpha, interleukin-1beta, and the reactive free radical, nitric oxide, at the transcriptional and translational levels. 5-(4-methoxybenzylidene)thiazolidine-2,4-dione 0-7 interleukin 1 beta Rattus norvegicus 184-201 22031851-8 2012 Compared with controls, Nx animals had higher plasma/kidney TNF-alpha and IL-1beta, which were reduced by curcumin and enalapril treatment. Curcumin 106-114 interleukin 1 beta Rattus norvegicus 74-82 22031851-8 2012 Compared with controls, Nx animals had higher plasma/kidney TNF-alpha and IL-1beta, which were reduced by curcumin and enalapril treatment. Enalapril 119-128 interleukin 1 beta Rattus norvegicus 74-82 21918525-8 2012 In an in vitro experiment using macrophages, we showed that lipopolysaccharide (LPS)-primed macrophages from the DS rats released more interleukin-1 beta in response to BzATP, a P2X(7) receptor agonist, than the macrophages from Lewis rats, possibly due to higher P2X(7) expression in the DS rats. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 169-174 interleukin 1 beta Rattus norvegicus 135-153 22210452-4 2012 KEY FINDINGS: Telmisartan treatment effectively suppressed myocardial protein and mRNA expressions of inflammatory markers [CD68, iNOS, NF-kB, interleukin-1beta, interferon-gamma, monocyte chemotactic protein-1] in comparison to vehicle-treated rats. Telmisartan 14-25 interleukin 1 beta Rattus norvegicus 143-160 21790532-11 2012 Ethanol enhanced serum IL-1beta at 2 h, but did not affect increased hepatic IL-1beta expression at 72 h after H/R. Ethanol 0-7 interleukin 1 beta Rattus norvegicus 23-31 21468628-6 2012 By ELISA techniques, higher levels of TNF-alpha and IL-1beta in lung and kidney tissues were measured in the IR group than in the control and DEX groups, these were verified by immunohistochemistry. Dexamethasone 142-145 interleukin 1 beta Rattus norvegicus 52-60 25774170-7 2012 Treatment of rats with gastrodin or Madopar at 28 days significantly reduced interleukin-1beta expression. gastrodin 23-32 interleukin 1 beta Rattus norvegicus 77-94 25774170-7 2012 Treatment of rats with gastrodin or Madopar at 28 days significantly reduced interleukin-1beta expression. benserazide, levodopa drug combination 36-43 interleukin 1 beta Rattus norvegicus 77-94 25774170-10 2012 Gastrodin could protect dopaminergic neurons via inhibition of interleukin-1beta expression and neuroinflammation in the substantia nigra. gastrodin 0-9 interleukin 1 beta Rattus norvegicus 63-80 22215116-1 2012 The aim of this study was to examine the effect of the archetypal pro-inflammatory cytokine, interleukin-1beta (IL-1beta), on high-energy phosphate levels within an ex vivo rat organotypic hippocampal-slice culture (OHSC) preparation using phosphorus ((31)P) magnetic resonance spectroscopy (MRS). Phosphates 138-147 interleukin 1 beta Rattus norvegicus 93-110 22215116-1 2012 The aim of this study was to examine the effect of the archetypal pro-inflammatory cytokine, interleukin-1beta (IL-1beta), on high-energy phosphate levels within an ex vivo rat organotypic hippocampal-slice culture (OHSC) preparation using phosphorus ((31)P) magnetic resonance spectroscopy (MRS). Phosphates 138-147 interleukin 1 beta Rattus norvegicus 112-120 22215116-2 2012 Intrastriatal microinjection of IL-1beta induces a chronic reduction in the apparent diffusion coefficient (ADC) of tissue water, which may be indicative of metabolic failure as established by in vivo models of acute cerebral ischaemia. Water 123-128 interleukin 1 beta Rattus norvegicus 32-40 22172598-7 2012 Of the curcuminoids the furan RK-106 was the only compound to inhibit production of TNFalpha and IL-1beta in a monocytic cell-line THP-1 in vitro. furan 24-29 interleukin 1 beta Rattus norvegicus 97-105 22179086-3 2012 This study analyzes the effect of pioglitazone, a PPARgamma agonist, on interleukin-1beta-induced COX-2 expression and the role of reactive oxygen species (ROS) on this effect. Pioglitazone 34-46 interleukin 1 beta Rattus norvegicus 72-89 22196794-3 2012 We aimed to develop a rat model of TTO which, in turn, could be used to assay the levels of TNF-alpha and IL-1beta through the course of the infection. Tea Tree Oil 35-38 interleukin 1 beta Rattus norvegicus 106-114 22196794-13 2012 Ears treated with CDX had lower rates of otorrhea at all time points and lower levels of IL-1beta and TNF-alpha. Cefadroxil 18-21 interleukin 1 beta Rattus norvegicus 89-97 22179086-5 2012 Interleukin-1beta increased: 1) COX-2 protein and mRNA levels; 2) protein and mRNA levels of the NADPH oxidase subunit NOX-1, NADPH oxidase activity and ROS production; and 3) phosphorylation of inhibitor of nuclear factor kappa B (IkappaB) kinase (IKK) nuclear expression of the p65 nuclear factor kappa B (NF-kappaB) subunit and cell proliferation, all of which were reduced by apocynin (30 mumol/l). Reactive Oxygen Species 153-156 interleukin 1 beta Rattus norvegicus 0-17 22179086-6 2012 Interleukin-1beta-induced COX-2 expression was reduced by apocynin, tempol (10 mumol/l), catalase (1000 U/ml) and lactacystin (5 mumol/l). acetovanillone 58-66 interleukin 1 beta Rattus norvegicus 0-17 22179086-6 2012 Interleukin-1beta-induced COX-2 expression was reduced by apocynin, tempol (10 mumol/l), catalase (1000 U/ml) and lactacystin (5 mumol/l). tempol 68-74 interleukin 1 beta Rattus norvegicus 0-17 22179086-6 2012 Interleukin-1beta-induced COX-2 expression was reduced by apocynin, tempol (10 mumol/l), catalase (1000 U/ml) and lactacystin (5 mumol/l). lactacystin 114-125 interleukin 1 beta Rattus norvegicus 0-17 22179086-8 2012 Pioglitazone (10 mumol/l) reduced the effects of interleukin-1beta on: 1) COX-2 protein and mRNA levels; 2) NOX-1 protein and mRNA levels, NADPH oxidase activity and ROS production; and 3) p-IKK, p65 expressions and cell proliferation. Pioglitazone 0-12 interleukin 1 beta Rattus norvegicus 49-66 22305382-10 2012 At 10 days, simvastatin significantly attenuated the production of pro-inflammatory cytokines, IL-1beta, TNF-alpha, MCP-1 and IP-10, and Th17-polarizing cytokines, IL-6 and IL-17e, and inhibited allograft infiltration by inflammatory cells. Simvastatin 12-23 interleukin 1 beta Rattus norvegicus 95-103 22179086-8 2012 Pioglitazone (10 mumol/l) reduced the effects of interleukin-1beta on: 1) COX-2 protein and mRNA levels; 2) NOX-1 protein and mRNA levels, NADPH oxidase activity and ROS production; and 3) p-IKK, p65 expressions and cell proliferation. Reactive Oxygen Species 166-169 interleukin 1 beta Rattus norvegicus 49-66 22179086-11 2012 In addition, pioglitazone increased the interleukin-1beta-induced PPARgamma mRNA levels. Pioglitazone 13-25 interleukin 1 beta Rattus norvegicus 40-57 22179086-12 2012 CONCLUSION: PPARgamma activation with pioglitazone reduces interleukin-1beta-induced COX-2 expression by interference with the redox-sensitive transcription factor NF-kappaB. Pioglitazone 38-50 interleukin 1 beta Rattus norvegicus 59-76 22129064-4 2012 RHSE inhibited alloxan-induced nitric oxide (NO) generation through inhibition of inducible nitric oxide synthase (iNOS) gene expression and suppressed the inflammatory reaction in INS-1 cells through inhibition of expression of pro-inflammatory genes, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6). Alloxan 15-22 interleukin 1 beta Rattus norvegicus 304-321 22240811-3 2012 Treatment of 832/13 rat INS-1-derived cells with 25 mm glucose and the proinflammatory cytokine IL-1beta led to a similar loss of SERCA2b expression, which was prevented by treatment with the peroxisome proliferator-activated receptor (PPAR)-gamma agonist, pioglitazone. Pioglitazone 257-269 interleukin 1 beta Rattus norvegicus 96-104 22129064-4 2012 RHSE inhibited alloxan-induced nitric oxide (NO) generation through inhibition of inducible nitric oxide synthase (iNOS) gene expression and suppressed the inflammatory reaction in INS-1 cells through inhibition of expression of pro-inflammatory genes, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6). Alloxan 15-22 interleukin 1 beta Rattus norvegicus 323-331 22119283-9 2012 In vitro assays revealed that 4-methylesculetin promoted an inhibition in IL-1beta, IL-8, IL-2 and IFN-gamma production in cell cultures. 4-methylesculetin 30-47 interleukin 1 beta Rattus norvegicus 74-82 22056485-8 2012 With the exception of the high TNF-alpha mRNA expression in 3-month-old zi/zi midbrains, chronic treatment of melatonin attenuated expressional changes of IL-1beta, CAT, SOD1, and GPx1. Melatonin 110-119 interleukin 1 beta Rattus norvegicus 155-163 22158106-6 2012 RESULTS: Gly (6 mg/kg) administered intravenously 30 min before inducing the transient lumbar spinal cord ischemia significantly improved the hind-limb motor function scores, and reduced the number of apoptotic neurons, which was accompanied by reduced levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in the plasma and injured spinal cord. Glycyrrhizic Acid 9-12 interleukin 1 beta Rattus norvegicus 304-321 22036618-3 2012 Since norepinephrine (NE) is involved in these effects, we hypothesized that IL-1beta acts on brainstem noradrenergic nuclei to affect gene transcription of NE synthesizing enzymes, cytokines and associated transcription factors. Norepinephrine 6-20 interleukin 1 beta Rattus norvegicus 77-85 22158106-6 2012 RESULTS: Gly (6 mg/kg) administered intravenously 30 min before inducing the transient lumbar spinal cord ischemia significantly improved the hind-limb motor function scores, and reduced the number of apoptotic neurons, which was accompanied by reduced levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in the plasma and injured spinal cord. Glycyrrhizic Acid 9-12 interleukin 1 beta Rattus norvegicus 323-331 22946894-3 2012 Further, the role of proinflammatory cytokines like TNF-alpha and IL-1beta, cyclooxygenases (COX-1 and COX-2), and free radicals in the action of flavone derivatives was investigated using in vitro assays. flavone 146-153 interleukin 1 beta Rattus norvegicus 66-74 23080163-5 2012 Recently, we found that CIH-induced increase expression of TNF-a and IL-1b within the CB. cih 24-27 interleukin 1 beta Rattus norvegicus 69-74 23080163-9 2012 Exposure to CIH significantly increases the immunorreactive levels of TNF-a and IL-1b in the CB, along with an increase accumulation of the p65 NF-kb subunit. cih 12-15 interleukin 1 beta Rattus norvegicus 80-85 23080163-10 2012 Treating rats with ibuprofen significantly prevents the CIH-induced increases in TNF-a and IL-1b in the CB chemoreceptor cells but failed to decrease the enhanced CB chemosensory reactivity to hypoxia. Ibuprofen 19-28 interleukin 1 beta Rattus norvegicus 91-96 23080163-10 2012 Treating rats with ibuprofen significantly prevents the CIH-induced increases in TNF-a and IL-1b in the CB chemoreceptor cells but failed to decrease the enhanced CB chemosensory reactivity to hypoxia. cih 56-59 interleukin 1 beta Rattus norvegicus 91-96 22454687-5 2012 In addition, paeonol reduced proinflammatory cytokines in bronchoalveolar lavage fluid, including tumor-necrosis factor-alpha, interleukin-1beta, interleukin-6, and plasminogen-activated inhibition factor-1. paeonol 13-20 interleukin 1 beta Rattus norvegicus 127-144 22878260-8 2012 However, pretreatment with osthole restored the mRNA and protein levels of these factors, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) of ischemic penumbra cortices, suggesting that osthole possessed the function of preventing brain against ischemic damage, while no significant difference was found in any of normal groups with or without osthole. osthol 27-34 interleukin 1 beta Rattus norvegicus 141-159 22878260-8 2012 However, pretreatment with osthole restored the mRNA and protein levels of these factors, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) of ischemic penumbra cortices, suggesting that osthole possessed the function of preventing brain against ischemic damage, while no significant difference was found in any of normal groups with or without osthole. osthol 27-34 interleukin 1 beta Rattus norvegicus 161-169 21744117-5 2012 A mechanistic study found that the protective effect of AOE against 6-OHDA-induced neuronal injury involved anti-inflammatory action (down-regulation of gene expression of IL-1beta and TNF-alpha) and anti-oxidative action (inhibition of NO production and iNOS expression in PC12 cells). Oxidopamine 68-74 interleukin 1 beta Rattus norvegicus 172-180 21926608-11 2012 In multiple anesthetic dose studies, plasma corticosterone concentrations were persistently lower and peak plasma interleukin-1beta and interleukin-6 concentrations were higher in the etomidate group vs. the carboetomidate and control groups. Etomidate 184-193 interleukin 1 beta Rattus norvegicus 114-131 22293346-5 2012 In addition gomisin A treatment ameliorated mRNA levels of CCl(4)-induced inflammatory mediators, including tumor necrosis factor-alpha, interleukin-1beta and inducible nitric oxide (NO) synthase, and the protein levels of transcriptional upregulator nuclear factor kappa B (NF-kappaB) and phospho-inhibitor of NF-kappaB (IkappaB). schizandrol B 12-21 interleukin 1 beta Rattus norvegicus 137-154 21466437-9 2012 Resveratrol treatment reversed the DENAinduced alteration of the level and expression of hepatic TNF-alpha, IL-1beta and IL-6. Resveratrol 0-11 interleukin 1 beta Rattus norvegicus 108-116 21614028-6 2012 TNF soluble receptor expressed by HSV vector reduced gene transcription of spinal TNFalpha and interleukin-1beta (IL-1beta) induced by repeated morphine. Morphine 144-152 interleukin 1 beta Rattus norvegicus 95-112 21614028-6 2012 TNF soluble receptor expressed by HSV vector reduced gene transcription of spinal TNFalpha and interleukin-1beta (IL-1beta) induced by repeated morphine. Morphine 144-152 interleukin 1 beta Rattus norvegicus 114-122 21614028-7 2012 Furthermore, we found that TNF soluble receptor mediated by HSV reversed the upregulation of protein level of TNFalpha and IL-1beta and phosphorylation of p38 mitogen-activated protein kinase induced by repeated morphine. Morphine 212-220 interleukin 1 beta Rattus norvegicus 123-131 22582804-10 2012 DOX significantly increased serum TNF-alpha and IL-1beta compared with those in control rats, and 1 significantly reduced the serum levels of TNF-alpha and IL-1beta. Doxorubicin 0-3 interleukin 1 beta Rattus norvegicus 48-56 22178418-8 2012 Levels of pro-inflammatory cytokines such as TNF-alpha, IL-1beta and IL-6 in plasma and joint extracts were reduced (p<0.0001) significantly in response to suramin treatment. Suramin 159-166 interleukin 1 beta Rattus norvegicus 56-64 22168577-13 2012 The key inflammatory regulators IL-1beta and NFkappaB were inhibited in the presence of surface-complexed Fe possibly through decreased ERK signaling upstream of the NALP3 inflammasome. Iron 106-108 interleukin 1 beta Rattus norvegicus 32-40 22052053-7 2012 Furthermore, tamoxifen abrogated IL-1beta- and angiotensin-II-induced proliferation of fibroblasts from both kidney explants and from the NRK-49F cell line. Tamoxifen 13-22 interleukin 1 beta Rattus norvegicus 33-42 22582804-10 2012 DOX significantly increased serum TNF-alpha and IL-1beta compared with those in control rats, and 1 significantly reduced the serum levels of TNF-alpha and IL-1beta. Doxorubicin 0-3 interleukin 1 beta Rattus norvegicus 156-164 21898537-8 2012 Consumption of Suppl SB resulted in decreased serum VEGF levels (18.42%), N-acetylglucosaminidase activity (27.77%), IL1beta concentration (9.07%), and NO released (77.06%), accompanied by a reduced redox state as observed by increased GSH/GSSG ratio (to 198.80%). suppl sb 15-23 interleukin 1 beta Rattus norvegicus 117-124 22529518-6 2012 Applying zerumbone also has been shown to inhibit NF-kappaB protein and downregulation of ICAM-1 and IL-1beta mRNA. zerumbone 9-18 interleukin 1 beta Rattus norvegicus 101-109 22450006-5 2012 RESULTS: Gefitinib treatment increased the infiltration of inflammatory cells, which produced more pro-inflammatory cytokines (IL-6, IL-1beta), in the lungs of the irradiated rats on days 15 and 57, while gefitinib treatment reduced collagen content of the lungs in irradiated rats and decreased proliferation and EGFR expression in the lung fibroblasts from irradiated rats on day 57. Gefitinib 9-18 interleukin 1 beta Rattus norvegicus 133-141 21951109-12 2012 After freeze-injury of the sciatic nerve, administration of etifoxine also strongly reduced the number of activated macrophages and decreased the production of the inflammatory cytokines tumour necrosis factor-alpha and interleukin-1beta. etifoxine 60-69 interleukin 1 beta Rattus norvegicus 220-237 22619518-9 2012 A significant decrease was observed in expression of cytokines interleukin 1 beta in the three treatment groups, in comparison with untreated challenged tendons, although, in the group treated with diclofenac and GNP, results were similar to the control (1.732 +- 239) (P < 0.05). Diclofenac 198-208 interleukin 1 beta Rattus norvegicus 63-81 22619518-9 2012 A significant decrease was observed in expression of cytokines interleukin 1 beta in the three treatment groups, in comparison with untreated challenged tendons, although, in the group treated with diclofenac and GNP, results were similar to the control (1.732 +- 239) (P < 0.05). LHRH (1-6) 213-216 interleukin 1 beta Rattus norvegicus 63-81 22529518-7 2012 The present paper suggests that treatment of zerumbone on rat attenuates the severity of acute necrotizing pancreatitis and pancreatitis-induced hepatic injury, via inhibiting NF-kappaB activation and downregulating the expression of ICAM-1 and IL-1beta. zerumbone 45-54 interleukin 1 beta Rattus norvegicus 245-253 22919443-3 2012 We first established that quercetin and sesamin defend microglial cells against MPP(+)-induced increases in the mRNA or protein levels of 3 pro-inflammatory cytokines (interleukin-6, IL-1beta and tumor necrosis factor-alpha), as revealed by real time-quantitative polymerase chain reaction and enzyme-linked immunoabsorbent assay, respectively. Quercetin 26-35 interleukin 1 beta Rattus norvegicus 183-223 22922655-11 2012 Furthermore, colchicine-treated pups had lower lung homogenate TNF-alpha and IL-1beta levels compared with the hyperoxia group (p < 0.05). Colchicine 13-23 interleukin 1 beta Rattus norvegicus 77-85 22777139-7 2012 Local injection of AEA (10(-8)M, 30 microl) decreased corticosterone plasma levels and the content of the cytokines TNF-alpha and IL-1beta in gingival tissue in periodontitis-stress groups. anandamide 19-22 interleukin 1 beta Rattus norvegicus 130-138 22797174-0 2012 IL-1beta induction and IL-6 suppression are associated with aggravated neuronal damage in a lipopolysaccharide-pretreated kainic acid-induced rat pup seizure model. Kainic Acid 122-133 interleukin 1 beta Rattus norvegicus 0-8 23112571-5 2012 IMD-0354, N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide, selectively inhibits IKKbeta, particularly when induced by proinflammatory cytokines, such as TNF-alpha and IL-1beta. N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide 10-71 interleukin 1 beta Rattus norvegicus 181-189 21839099-13 2012 When administered alone, DMP904 had no significant effect on p38 MAPK or phospho-p38 MAPK in the hippocampus, but when given with IL-1beta led to increased phosphorylation of p38 MAPK. 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine 25-31 interleukin 1 beta Rattus norvegicus 130-138 21839099-16 2012 DMP904 blocked some of the neurochemical effects of IL-1beta, but did not impact the behavioral measures, or serum cytokines. 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine 0-6 interleukin 1 beta Rattus norvegicus 52-60 22919443-3 2012 We first established that quercetin and sesamin defend microglial cells against MPP(+)-induced increases in the mRNA or protein levels of 3 pro-inflammatory cytokines (interleukin-6, IL-1beta and tumor necrosis factor-alpha), as revealed by real time-quantitative polymerase chain reaction and enzyme-linked immunoabsorbent assay, respectively. sesamin 40-47 interleukin 1 beta Rattus norvegicus 183-223 22166439-8 2012 Fluoxetine significantly inhibited LPS-induced activation of microglia and subsequent release of multiple pro-inflammatory and cytotoxic factors including tumor necrosis factor-alpha, interleukin-1beta, nitric oxide, and reactive oxygen species. Fluoxetine 0-10 interleukin 1 beta Rattus norvegicus 184-201 23406756-8 2012 RESULTS: IL-1beta significantly increased plasma ACTH, corticosterone and IL-1beta levels during 2 h after ip administration. Corticosterone 55-69 interleukin 1 beta Rattus norvegicus 9-17 23406756-9 2012 IL-1 receptor antagonist was able to abolish the stimulatory effect of IL-1beta on plasma ACTH and corticosterone levels and significantly, but not totally, reduced plasma IL-1beta level. Corticosterone 99-113 interleukin 1 beta Rattus norvegicus 71-79 23166749-3 2012 The present study showed that PF treatment for 14 days could significantly inhibit transient middle cerebral artery occlusion (MCAO)-induced over-activation of astrocytes and microglia, and prevented up-regulations of pro-inflamamtory mediators (TNFalpha, IL-1beta, iNOS, COX(2) and 5-LOX) in plasma and brain. peoniflorin 30-32 interleukin 1 beta Rattus norvegicus 256-264 23251531-0 2012 Isoflurane induces learning impairment that is mediated by interleukin 1beta in rodents. Isoflurane 0-10 interleukin 1 beta Rattus norvegicus 59-76 23251531-10 2012 Isoflurane increased the expression of interleukin 1beta (IL-1beta), interleukin-6 and activated caspase 3 in the hippocampus of the 18-month old rats. Isoflurane 0-10 interleukin 1 beta Rattus norvegicus 39-56 23251531-10 2012 Isoflurane increased the expression of interleukin 1beta (IL-1beta), interleukin-6 and activated caspase 3 in the hippocampus of the 18-month old rats. Isoflurane 0-10 interleukin 1 beta Rattus norvegicus 58-66 23251531-12 2012 The increase of IL-1beta and activated caspase 3 but not interleukin-6 was attenuated by lidocaine. Lidocaine 89-98 interleukin 1 beta Rattus norvegicus 16-24 23251531-16 2012 IL-1beta may play an important role in this isoflurane effect. Isoflurane 44-54 interleukin 1 beta Rattus norvegicus 0-8 22768159-7 2012 Intrathecal injection of spironolactone significantly attenuated pain behaviors as well as the expression of microglia, IL-1beta, TNF-alpha, t-NR1, and p-NR1, whereas the production of IL-6 wasn"t affected. Spironolactone 25-39 interleukin 1 beta Rattus norvegicus 120-128 23071661-5 2012 Systemically, plasma of folinic acid supplemented rats, in comparison to plasma from rats treated with MTX alone, contained a significantly lower level of IL-1beta and suppressed osteoclast formation in vitro in normal bone marrow cells. Leucovorin 24-36 interleukin 1 beta Rattus norvegicus 155-163 23071661-5 2012 Systemically, plasma of folinic acid supplemented rats, in comparison to plasma from rats treated with MTX alone, contained a significantly lower level of IL-1beta and suppressed osteoclast formation in vitro in normal bone marrow cells. Methotrexate 103-106 interleukin 1 beta Rattus norvegicus 155-163 23071661-6 2012 The importance of IL-1beta in supporting plasma-induced osteoclast formation was confirmed as the presence of an anti-IL-1beta neutralizing antibody attenuated the ability of the plasma (from MTX-treated rats) in inducing osteoclast formation. Methotrexate 192-195 interleukin 1 beta Rattus norvegicus 18-26 23071661-6 2012 The importance of IL-1beta in supporting plasma-induced osteoclast formation was confirmed as the presence of an anti-IL-1beta neutralizing antibody attenuated the ability of the plasma (from MTX-treated rats) in inducing osteoclast formation. Methotrexate 192-195 interleukin 1 beta Rattus norvegicus 118-126 22802969-3 2012 FcepsilonRIota-evoked degranulation, calcium mobilization, and synthesis of cytokine transcripts (IL-1beta, IL-10, and monocyte chemoattractant protein 1 (MCP-1)) were reduced in Shp2 knockdown RBL cells. fcepsilonriota 0-14 interleukin 1 beta Rattus norvegicus 98-106 22715380-10 2012 The protein expression levels of IL-1beta and IL-6 in the serum samples from the control, HF, and HF+GTP groups confirmed the results of gene expression. Guanosine Triphosphate 101-104 interleukin 1 beta Rattus norvegicus 33-41 22126533-7 2012 Tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta were elevated in the DSS group compared with controls. Dextran Sulfate 82-85 interleukin 1 beta Rattus norvegicus 38-60 22701621-5 2012 In this study, we used streptozotocin (STZ)-induced diabetic nephropathy model with hyperuricemia and dyslipidemia in rats, and found over-expression of renal inflammasome components NLRP3, apoptosis-associated speck-like protein and Caspase-1, resulting in elevation of IL-1beta and IL-18, with subsequently deteriorated renal injury. Streptozocin 23-37 interleukin 1 beta Rattus norvegicus 271-279 22615852-0 2012 IL-1beta is upregulated in the diabetic retina and retinal vessels: cell-specific effect of high glucose and IL-1beta autostimulation. Glucose 97-104 interleukin 1 beta Rattus norvegicus 0-8 22615852-4 2012 The aim of this study was to investigate the effect of high glucose and IL-1beta itself on IL-1beta expression in microglial, macroglial (astrocytes and Muller cells) and retinal vascular endothelial cells; and to study the effect of diabetes on the expression of IL-1beta in isolated retinal vessels and on the temporal pattern of IL-1beta upregulation and glial reactivity in the retina of streptozotocin-diabetic rats. Glucose 60-67 interleukin 1 beta Rattus norvegicus 91-99 22615852-4 2012 The aim of this study was to investigate the effect of high glucose and IL-1beta itself on IL-1beta expression in microglial, macroglial (astrocytes and Muller cells) and retinal vascular endothelial cells; and to study the effect of diabetes on the expression of IL-1beta in isolated retinal vessels and on the temporal pattern of IL-1beta upregulation and glial reactivity in the retina of streptozotocin-diabetic rats. Glucose 60-67 interleukin 1 beta Rattus norvegicus 91-99 22615852-4 2012 The aim of this study was to investigate the effect of high glucose and IL-1beta itself on IL-1beta expression in microglial, macroglial (astrocytes and Muller cells) and retinal vascular endothelial cells; and to study the effect of diabetes on the expression of IL-1beta in isolated retinal vessels and on the temporal pattern of IL-1beta upregulation and glial reactivity in the retina of streptozotocin-diabetic rats. Glucose 60-67 interleukin 1 beta Rattus norvegicus 91-99 22615852-6 2012 We found that high glucose induced a 3-fold increase of IL-1beta expression in retinal endothelial cells but not in macroglia and microglia. Glucose 19-26 interleukin 1 beta Rattus norvegicus 56-64 22615852-8 2012 In retinal endothelial cells, the high glucose-induced IL-1beta overexpression was prevented by calphostin C, a protein kinase C inhibitor. Glucose 39-46 interleukin 1 beta Rattus norvegicus 55-63 22615852-8 2012 In retinal endothelial cells, the high glucose-induced IL-1beta overexpression was prevented by calphostin C, a protein kinase C inhibitor. calphostin C 96-108 interleukin 1 beta Rattus norvegicus 55-63 22359588-4 2012 The in vitro anti-arthritic activity of magnolol was tested on interleukin (IL)-1beta-stimulated FLS by measuring levels of IL-6, cyclooxygenase-2, prostaglandin E(2), and matrix metalloproteinases (MMPs) by ELISA and RT-PCR. magnolol 40-48 interleukin 1 beta Rattus norvegicus 63-85 22359588-5 2012 Further studies on how magnolol inhibits IL-1beta-stimulated cytokine expression were performed using Western blots, reporter gene assay, electrophoretic mobility shift assay, and confocal microscope analysis. magnolol 23-31 interleukin 1 beta Rattus norvegicus 41-49 22359588-7 2012 Magnolol markedly inhibited IL-1beta (10 ng/mL)-induced cytokine expression in a concentration-dependent manner (2.5-25 microg/mL). magnolol 0-8 interleukin 1 beta Rattus norvegicus 28-36 22359588-8 2012 In clarifying the mechanisms involved, magnolol was found to inhibit the IL-1beta-induced activation of the IKK/IkappaB/NF-kappaB and MAPKs pathways by suppressing the nuclear translocation and DNA binding activity of both transcription factors. magnolol 39-47 interleukin 1 beta Rattus norvegicus 73-81 22701621-5 2012 In this study, we used streptozotocin (STZ)-induced diabetic nephropathy model with hyperuricemia and dyslipidemia in rats, and found over-expression of renal inflammasome components NLRP3, apoptosis-associated speck-like protein and Caspase-1, resulting in elevation of IL-1beta and IL-18, with subsequently deteriorated renal injury. Streptozocin 39-42 interleukin 1 beta Rattus norvegicus 271-279 22171672-11 2011 It stimulated release of sAPP and glutamate in these cultures too, and both of these agents--as well as Abeta--stimulated ApoE expression themselves, suggesting that they may contribute to the effect of IL-1beta on ApoE levels. sapp 25-29 interleukin 1 beta Rattus norvegicus 203-211 22359633-17 2012 In addition, L-cysteine increased the mRNA expression of Nrf2, NQO1 and HO-1 and reduced the expression of IL-1beta in L-cysteine treated group when compared with control group. Cysteine 13-23 interleukin 1 beta Rattus norvegicus 107-115 22359633-17 2012 In addition, L-cysteine increased the mRNA expression of Nrf2, NQO1 and HO-1 and reduced the expression of IL-1beta in L-cysteine treated group when compared with control group. Cysteine 119-129 interleukin 1 beta Rattus norvegicus 107-115 22219595-13 2011 Additionally, rosiglitazone significantly reduced the concentration of TNF-alpha, IL-1beta, IL-6 and ALT in sham-operated rats, but not in BDL rats, in response to LPS (3 mg/kg). Rosiglitazone 14-27 interleukin 1 beta Rattus norvegicus 82-90 22210172-7 2011 Results showed that sevoflurane postconditioning can decrease serum tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), nitric oxide (NO), nitric oxide synthase (NOS) and increase serum interleukin-10 (IL-10) levels in cerebral ischemia reperfusion rats. Sevoflurane 20-31 interleukin 1 beta Rattus norvegicus 109-127 22210172-7 2011 Results showed that sevoflurane postconditioning can decrease serum tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), nitric oxide (NO), nitric oxide synthase (NOS) and increase serum interleukin-10 (IL-10) levels in cerebral ischemia reperfusion rats. Sevoflurane 20-31 interleukin 1 beta Rattus norvegicus 129-137 21983654-7 2011 Moreover, the treatments with apocynin and indomethacin blunted the effect of FA on the generation of IL-1beta, while the treatments with L-NAME and apocynin reduced the generation of IL-6 by lung explants when compared to the untreated group. acetovanillone 30-38 interleukin 1 beta Rattus norvegicus 102-110 21983654-7 2011 Moreover, the treatments with apocynin and indomethacin blunted the effect of FA on the generation of IL-1beta, while the treatments with L-NAME and apocynin reduced the generation of IL-6 by lung explants when compared to the untreated group. Indomethacin 43-55 interleukin 1 beta Rattus norvegicus 102-110 21700370-5 2011 RESULTS: IR and systemic and adipose tissue inflammation (TNFalpha and IL1beta) were improved in the HFO group. 1,3,3,3-tetrafluoropropene 101-104 interleukin 1 beta Rattus norvegicus 71-78 22159112-5 2011 In primary microglial cultures, administration of iron chelator deferoxamine reduced the generation of iron-induced reactive oxygen and nitrogen species and proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-1beta. Iron 50-54 interleukin 1 beta Rattus norvegicus 223-240 22159112-5 2011 In primary microglial cultures, administration of iron chelator deferoxamine reduced the generation of iron-induced reactive oxygen and nitrogen species and proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-1beta. Deferoxamine 64-76 interleukin 1 beta Rattus norvegicus 223-240 22159112-5 2011 In primary microglial cultures, administration of iron chelator deferoxamine reduced the generation of iron-induced reactive oxygen and nitrogen species and proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-1beta. Iron 103-107 interleukin 1 beta Rattus norvegicus 223-240 21971020-11 2011 PTX reduced plasma IL-1beta concentrations in both sham and MI rats. Pentoxifylline 0-3 interleukin 1 beta Rattus norvegicus 19-27 21983485-7 2011 Furthermore, levels of inflammatory mediators (nitric oxide, TNF-alpha, IL-1beta, IL-6) measured in both plasma and joint exudates were significantly reduced by SNME treatment. snme 161-165 interleukin 1 beta Rattus norvegicus 72-80 21945291-7 2011 These results indicate, at least in part, that prophylactic lithium can alleviate surgery-associated impairment of the spatial memory in aged rats which is strongly associated with the reduced levels of hippocampal p-GSK-3beta and IL-1beta resulted from the activation of PI3K/AKT/mTORC2 pathway. Lithium 60-67 interleukin 1 beta Rattus norvegicus 231-239 21958968-6 2011 In addition, treatment with PA (10-40 mg/kg) also dose-dependently decreased the production of TNF-alpha, IL-1beta, PGE2 and NO in the hind paw of carrageenan-treated rats. patchouli alcohol 28-30 interleukin 1 beta Rattus norvegicus 106-114 21958968-6 2011 In addition, treatment with PA (10-40 mg/kg) also dose-dependently decreased the production of TNF-alpha, IL-1beta, PGE2 and NO in the hind paw of carrageenan-treated rats. Carrageenan 147-158 interleukin 1 beta Rattus norvegicus 106-114 21958968-7 2011 Furthermore, PA treatment also suppressed the mRNA expression of TNF-alpha, IL-1beta, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the hind paw of carrageenan-treated rats. patchouli alcohol 13-15 interleukin 1 beta Rattus norvegicus 76-84 21958968-8 2011 These results suggest that PA possesses potent anti-inflammatory activity, which may be mediated, at least in part, by down-regulating the mRNA expression of a panel of inflammatory mediators including TNF-alpha, IL-1beta, iNOS and COX-2. patchouli alcohol 27-29 interleukin 1 beta Rattus norvegicus 213-221 22060287-7 2011 Elevated TNF-alpha and IL-1beta levels were also reduced with CAPE treatment. caffeic acid phenethyl ester 62-66 interleukin 1 beta Rattus norvegicus 23-31 21983642-8 2011 The overproduction and mRNA expression of TNF-alpha, IL-1beta and IL-6 were remarkably suppressed in serum and synovium tissue of all TCDCA-treated rats, however, IL-10 was markedly increased in prophylactic treatment. Taurochenodeoxycholic Acid 134-139 interleukin 1 beta Rattus norvegicus 53-61 21983642-9 2011 In a definite concentration ranging from 300 mug/mL to 500 mug/mL, TCDCA showed marked inhibition in the overproduction and mRNA expression of TNF-alpha, IL-1beta and IL-6 in synoviocytes in a concentration-dependent manner, but opposite action on IL-10. Taurochenodeoxycholic Acid 67-72 interleukin 1 beta Rattus norvegicus 154-162 21983642-10 2011 In conclusion, treatment with TCDCA confers a good anti-adjuvant arthritis activity in rats, which its reparative effects could be mediated via reduction of the protein and mRNA expression of TNF-alpha, IL-1beta and IL-6, and augment of IL-10 in rats. Taurochenodeoxycholic Acid 30-35 interleukin 1 beta Rattus norvegicus 203-211 21824496-12 2011 Escitalopram lowered TNF-alpha, IL-1beta, and PGE(2) levels in both groups of rats while IL-6 showed no differences whatsoever. Citalopram 0-12 interleukin 1 beta Rattus norvegicus 32-40 21864548-7 2011 IL-1beta in the hippocampus was increased at 6 h after isoflurane exposure. Isoflurane 55-65 interleukin 1 beta Rattus norvegicus 0-8 22001142-2 2011 We examined the effect of tetrandrine on interleukin-1beta (IL-1beta)-provoked inflammatory response in mesangial cells. tetrandrine 26-37 interleukin 1 beta Rattus norvegicus 41-58 22001142-2 2011 We examined the effect of tetrandrine on interleukin-1beta (IL-1beta)-provoked inflammatory response in mesangial cells. tetrandrine 26-37 interleukin 1 beta Rattus norvegicus 60-68 22039247-10 2011 With DTSH treatment, doxycycline inhibited the activity and expression of MMPs, the expression of VEGF and of phosphorylated VEGFR1 and VEGFR2, and the production of iNOS and IL-1beta in local cornea. dtsh 5-9 interleukin 1 beta Rattus norvegicus 175-183 22039247-10 2011 With DTSH treatment, doxycycline inhibited the activity and expression of MMPs, the expression of VEGF and of phosphorylated VEGFR1 and VEGFR2, and the production of iNOS and IL-1beta in local cornea. Doxycycline 21-32 interleukin 1 beta Rattus norvegicus 175-183 22039247-11 2011 CONCLUSIONS: Doxycycline enhances the inhibitory effects of bevacizumab on CNV and prevents its side effects on CWH, possibly by inhibiting the expression and activity of MMPs, the expression of VEGF and of phosphorylated VEGFR1 and VEGFR2, and the production of iNOS and IL-1beta. Doxycycline 13-24 interleukin 1 beta Rattus norvegicus 272-280 22114930-0 2011 Increased interleukin-1beta levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMA. N-Methyl-3,4-methylenedioxyamphetamine 54-58 interleukin 1 beta Rattus norvegicus 10-27 22114930-0 2011 Increased interleukin-1beta levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMA. N-Methyl-3,4-methylenedioxyamphetamine 130-134 interleukin 1 beta Rattus norvegicus 10-27 22114930-9 2011 RESULTS: Pretreatment with low dose MDMA attenuated both the 5-HT transporter loss and elevated IL-1beta levels induced by neurotoxic MDMA while producing an increase in IL-1ra levels. N-Methyl-3,4-methylenedioxyamphetamine 36-40 interleukin 1 beta Rattus norvegicus 96-104 22114930-10 2011 Low dose MDMA produced an increase in IL-1beta at 3 h and in IL-1ra at 96 h. sIL-1RI expression was also increased after low dose MDMA. N-Methyl-3,4-methylenedioxyamphetamine 9-13 interleukin 1 beta Rattus norvegicus 38-46 22114930-13 2011 Furthermore, IL-1beta (2.5 pg, intracortical) given 96 h before neurotoxic MDMA protected against the 5-HT neurotoxicity produced by the drug, thus mimicking preconditioning. N-Methyl-3,4-methylenedioxyamphetamine 75-79 interleukin 1 beta Rattus norvegicus 13-21 22114930-14 2011 CONCLUSIONS: These results suggest that IL-1beta plays an important role in the development of delayed preconditioning by low dose MDMA. N-Methyl-3,4-methylenedioxyamphetamine 131-135 interleukin 1 beta Rattus norvegicus 40-48 22001142-8 2011 At non-toxic concentrations, TET inhibited expression of phosphorylated ERK as well as phosphorylated IKK, enhanced degradation of IkappaBalpha and reduced the DNA-binding activity of NF-kappaB in IL-1beta-primed PRMCs, suggesting an inhibitory effect on ERK/NF-kappaB signaling. tetrandrine 29-32 interleukin 1 beta Rattus norvegicus 197-205 22001142-9 2011 TET attenuated the IL-1beta-provoked expression of iNOS and release of NO. tetrandrine 0-3 interleukin 1 beta Rattus norvegicus 19-27 21971118-8 2011 The atorvastatin administration also decreased the expression of TGF-beta1, IL-1beta, IL-6, TNF-alpha, PCNA and the labeling index of apoptotic cells in the smooth muscle layer of ligated ureters in the treated group. Atorvastatin 4-16 interleukin 1 beta Rattus norvegicus 76-84 22126765-6 2011 Cerebral ischemia-reperfusion caused significantly increased expressions of IL-1beta, TNF-alpha, caspase-3 and HSP-70 mRNA, and these changes were obviously reversed by PPTA, but not by edaravone. 5-((3,4-methylenedioxyphenylethane)methylamino)-1-p-hydroxyphenyl-1-penten-3-one 169-173 interleukin 1 beta Rattus norvegicus 76-84 21832250-10 2011 These findings support a novel role for autocrine P1 and P2 purinergic receptors coupled to cAMP signaling cascades and transcriptional induction of caspase-1 in mediating the high-glucose-induced activation of caspase-1 and secretion of IL-1beta in a cell culture model of nonhematopoietic retinal Muller cells. Glucose 181-188 interleukin 1 beta Rattus norvegicus 238-246 21645265-4 2011 Hydroquinone treatment induced the membrane expression of cell adhesion molecules (CAMs) from the immunoglobulin superfamilies ICAM-1 (intercellular), VCAM-1(vascular) and PECAM-1 (platelet endothelial) and induced the secretion of cytokines interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha). hydroquinone 0-12 interleukin 1 beta Rattus norvegicus 242-259 21645265-4 2011 Hydroquinone treatment induced the membrane expression of cell adhesion molecules (CAMs) from the immunoglobulin superfamilies ICAM-1 (intercellular), VCAM-1(vascular) and PECAM-1 (platelet endothelial) and induced the secretion of cytokines interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha). hydroquinone 0-12 interleukin 1 beta Rattus norvegicus 261-269 21764859-9 2011 Importantly, colon adenocarcinomas from atorvastatin and NSAIDs fed animals showed reduced key inflammatory markers, inducible nitric oxide synthase and COX-2, phospho-p65, as well as inflammatory cytokines, TNF-alpha, interleukin (IL)-1beta, and IL-4. Atorvastatin 40-52 interleukin 1 beta Rattus norvegicus 219-241 21636647-9 2011 RESULTS: p38 activity is increased in the brains of PCS rats and treatment with SB239063 reduces microglial activation, as well as inflammatory markers in brain (prostaglandin E2, cyclooxygenase activity, iNOS, IL-1beta, TNFalpha) and blood (prostaglandin E2 and TNFalpha). SB 239063 80-88 interleukin 1 beta Rattus norvegicus 211-219 21624097-7 2011 In the rats pretreated with TNF-alpha or IL-1beta but not in the rats pretreated with IL-4 or IL-13, sub-response dose of angiotensin II caused significant increases in the MAP and RSNA and enhancement in the CSAR. rsna 181-185 interleukin 1 beta Rattus norvegicus 41-49 21995525-9 2011 IL-1beta-exposed males and females had reduced oestradiol content in hippocampus, medial prefrontal cortex and diencephalon compared to controls. Estradiol 47-57 interleukin 1 beta Rattus norvegicus 0-8 21878382-9 2011 RESULTS: The administration of 10 and 20mg/kg GB could significantly suppress gene expressions of TLR-4 and NF-kappaB, lessen concentrations of TNF-alpha, IL-1beta and IL-6 as well as reduce number of apoptotic neuronal cells in hemorrhagic rat brain tissues by Least-significant Difference test (P<0.05), but the administration of 5mg/kg GB not (P>0.05). ginkgolide B 46-48 interleukin 1 beta Rattus norvegicus 155-163 21624097-8 2011 AT(1) receptor antagonist losartan in the PVN attenuated the effects of angiotensin II, TNF-alpha and IL-1beta, but not the effects of IL-4 and IL-13. Losartan 26-34 interleukin 1 beta Rattus norvegicus 102-110 21632157-9 2011 RESULTS: DHA led to a decreased VCAM-1, TLR4, cyclooxygenase-2 and VEGFR2 expression and a decreased production of IL-6, IL-8 and GM-CSF and a reduced production of PGE(2) and LTB(4) (p < 0.001) in IL-1beta-induced HIMEC. dehydroacetic acid 9-12 interleukin 1 beta Rattus norvegicus 201-209 21741371-3 2011 Thus, COX-1 is constitutive and expressed ubiquitously and serves a housekeeping role, while COX-2 is inducible or upregulated by inflammatory/injury stimuli such as interleukin-1beta, tumor necrosis factor-alpha, and lipopolysaccharide in macrophage, monocyte, synovial, liver, and lung, and is associated with prostaglandin E2 and prostacyclin production that evokes or sustains systemic/peripheral inflammatory symptoms. Dinoprostone 312-328 interleukin 1 beta Rattus norvegicus 166-212 21741371-3 2011 Thus, COX-1 is constitutive and expressed ubiquitously and serves a housekeeping role, while COX-2 is inducible or upregulated by inflammatory/injury stimuli such as interleukin-1beta, tumor necrosis factor-alpha, and lipopolysaccharide in macrophage, monocyte, synovial, liver, and lung, and is associated with prostaglandin E2 and prostacyclin production that evokes or sustains systemic/peripheral inflammatory symptoms. Epoprostenol 333-345 interleukin 1 beta Rattus norvegicus 166-212 21708146-16 2011 Microarray analysis showed that betaine feeding prevented the up regulation of a large number of genes including TLR2/4, Il-1b, Jax3, Sirt3, Fas, Ifngr1, Tgfgr2, Tnfrsf21, Lbp and Stat 3 which could explain how betaine prevented fatty liver. Betaine 32-39 interleukin 1 beta Rattus norvegicus 121-126 21763302-6 2011 In addition, isoproterenol induced group electrocardiogram showed an elevation in ST segments and increased expressions of interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha genes in the myocardium. Isoproterenol 13-26 interleukin 1 beta Rattus norvegicus 123-140 21763302-7 2011 Pretreatment with vanillic acid showed significant protective effects on cardiac troponins, lipid peroxidation, antioxidant system, electrocardiogram and expressions of interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha gene in the heart of isoproterenol induced cardiotoxic rats. Vanillic Acid 18-31 interleukin 1 beta Rattus norvegicus 169-186 21910168-7 2011 RESULTS: Intestinal permeability, diarrhea, myeloperoxidase, and interleukin-1beta levels were significantly lower in rats fed both antioxidants and calcium compared to rats supplemented with antioxidants only. Calcium 149-156 interleukin 1 beta Rattus norvegicus 65-82 22038352-10 2011 The levels of TNF-alpha and IL-1beta in the hippocampus were substantially elevated at each time point of measurement (P<0.05), and they also reached a peak value at about 3 h. Administration of NaHS significantly aggravated sepsis-associated hippocampus inflammation, as evidenced by TNF-alpha and IL-1beta activity and histological changes in hippocampus. sodium bisulfide 198-202 interleukin 1 beta Rattus norvegicus 28-36 21777577-5 2011 In addition, vanillin markedly attenuated the expression levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) and prevented CCl(4)-induced hepatic cell alteration and necrosis, as indicated by liver histopathology. vanillin 13-21 interleukin 1 beta Rattus norvegicus 143-160 21777577-5 2011 In addition, vanillin markedly attenuated the expression levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) and prevented CCl(4)-induced hepatic cell alteration and necrosis, as indicated by liver histopathology. vanillin 13-21 interleukin 1 beta Rattus norvegicus 162-170 21825230-6 2011 Moreover, GW0742 inhibited vascular superoxide production, downregulated p22(phox) and p47(phox) proteins, decreased both basal and angiotensin II-stimulated NADPH oxidase activity, inhibited extracellular-regulated kinase 1/2 activation, and reduced the expression of the proinflammatory and proatherogenic genes, interleukin 1beta, interleukin 6, or intercellular adhesion molecule 1. GW0742 10-16 interleukin 1 beta Rattus norvegicus 315-332 20865308-5 2011 We conclude that testosterone increases the expression of TNF-alpha, IL-1beta and CINC-1, and estradiol and progesterone increase the expression of IL-6. Testosterone 17-29 interleukin 1 beta Rattus norvegicus 69-77 22038352-10 2011 The levels of TNF-alpha and IL-1beta in the hippocampus were substantially elevated at each time point of measurement (P<0.05), and they also reached a peak value at about 3 h. Administration of NaHS significantly aggravated sepsis-associated hippocampus inflammation, as evidenced by TNF-alpha and IL-1beta activity and histological changes in hippocampus. sodium bisulfide 198-202 interleukin 1 beta Rattus norvegicus 302-310 21574817-7 2011 Compared with the control, BPA activated the phosphorylation of ERK1/2 (p-ERK1/2) through 30 min to 6 h. TF was down-regulated at 6 and 24 h. Furthermore, IL-1beta was up-regulated at 30 min and IL-6 was up-regulated at 1 and 24 h. ERK activity inhibitor (PD98059, 10 micromol/l) inhibited these molecular changes. bisphenol A 27-30 interleukin 1 beta Rattus norvegicus 155-163 21574817-7 2011 Compared with the control, BPA activated the phosphorylation of ERK1/2 (p-ERK1/2) through 30 min to 6 h. TF was down-regulated at 6 and 24 h. Furthermore, IL-1beta was up-regulated at 30 min and IL-6 was up-regulated at 1 and 24 h. ERK activity inhibitor (PD98059, 10 micromol/l) inhibited these molecular changes. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 256-263 interleukin 1 beta Rattus norvegicus 155-163 21645506-14 2011 amitriptyline at the applied doses markedly reduced interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha levels in the paw treated with carrageenan. Amitriptyline 0-13 interleukin 1 beta Rattus norvegicus 52-74 21457799-11 2011 Ibuprofen blocked increases in inflammatory cytokines (IL-1beta, IL-6) in the brainstem with chronic hypoxia. Ibuprofen 0-9 interleukin 1 beta Rattus norvegicus 55-63 21645506-14 2011 amitriptyline at the applied doses markedly reduced interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha levels in the paw treated with carrageenan. Carrageenan 144-155 interleukin 1 beta Rattus norvegicus 52-74 21645506-16 2011 amitriptyline noticeably decreased the concentration of IL-1beta in the inflamed paws. Amitriptyline 0-13 interleukin 1 beta Rattus norvegicus 56-64 21645506-19 2011 These results confirmed the anti-inflammatory effects of systemic and central amitriptyline in the carrageenan-induced paw edema in rats, and demonstrated that these effects mediated mostly through the inhibition of PMN cells migration and release of IL-1beta and TNF-alpha into the site of inflammation. Amitriptyline 78-91 interleukin 1 beta Rattus norvegicus 251-259 21596875-4 2011 Our present study was designed to examine the hypotheses that (1) CCI-induced neuropathic pain may be associated with increased production of TNF-alpha and IL-1beta, (2) HBOT may alleviate CCI-induced neuropathic pain, and (3) the alleviated neuropathic pain may be associated with reduced production of TNF-alpha and/or IL-1beta. CCI 66-69 interleukin 1 beta Rattus norvegicus 156-164 22125677-6 2011 The mean serum levels of CRP and IL-1beta were significantly lower (P < 0.05) in the cranberry powder groups compared to those in HL rats. cranberry powder 88-104 interleukin 1 beta Rattus norvegicus 33-41 21762681-10 2011 The higher expressions of pro-inflammatory cytokines such as interleukin-1beta, interleukin-6 and tumour necrosis factor-alpha in the isoproterenol-induced rats were controlled by the pretreatment with ellagic acid. Isoproterenol 134-147 interleukin 1 beta Rattus norvegicus 61-78 21762681-10 2011 The higher expressions of pro-inflammatory cytokines such as interleukin-1beta, interleukin-6 and tumour necrosis factor-alpha in the isoproterenol-induced rats were controlled by the pretreatment with ellagic acid. Ellagic Acid 202-214 interleukin 1 beta Rattus norvegicus 61-78 21596875-4 2011 Our present study was designed to examine the hypotheses that (1) CCI-induced neuropathic pain may be associated with increased production of TNF-alpha and IL-1beta, (2) HBOT may alleviate CCI-induced neuropathic pain, and (3) the alleviated neuropathic pain may be associated with reduced production of TNF-alpha and/or IL-1beta. CCI 66-69 interleukin 1 beta Rattus norvegicus 321-329 21596875-4 2011 Our present study was designed to examine the hypotheses that (1) CCI-induced neuropathic pain may be associated with increased production of TNF-alpha and IL-1beta, (2) HBOT may alleviate CCI-induced neuropathic pain, and (3) the alleviated neuropathic pain may be associated with reduced production of TNF-alpha and/or IL-1beta. CCI 189-192 interleukin 1 beta Rattus norvegicus 156-164 21596875-4 2011 Our present study was designed to examine the hypotheses that (1) CCI-induced neuropathic pain may be associated with increased production of TNF-alpha and IL-1beta, (2) HBOT may alleviate CCI-induced neuropathic pain, and (3) the alleviated neuropathic pain may be associated with reduced production of TNF-alpha and/or IL-1beta. CCI 189-192 interleukin 1 beta Rattus norvegicus 321-329 21434880-8 2011 KEY RESULTS: NMDA injection enhanced TXNIP expression, decreased Trx activity, causing increased oxidative stress, glial activation and release of TNF-alpha and IL-1beta. N-Methylaspartate 13-17 interleukin 1 beta Rattus norvegicus 161-169 21745559-9 2011 RESULTS: Kirenol (1, 2, and 4 mg/kg) and prednisolone depressed paw swelling and reduced IL-1beta of synovial fluid in the CIA rats (p<0.05 or p<0.01). kirenol 9-16 interleukin 1 beta Rattus norvegicus 89-97 21745559-9 2011 RESULTS: Kirenol (1, 2, and 4 mg/kg) and prednisolone depressed paw swelling and reduced IL-1beta of synovial fluid in the CIA rats (p<0.05 or p<0.01). Prednisolone 41-53 interleukin 1 beta Rattus norvegicus 89-97 21624390-8 2011 Morphine-tolerant rats expressed high levels of the pro-inflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha and the increase in interleukin-1beta and interleukin-6, and tumor necrosis factor-alpha levels was prevented by MK-801 pre-treatment at both the protein and mRNA levels. Morphine 0-8 interleukin 1 beta Rattus norvegicus 79-96 21624390-8 2011 Morphine-tolerant rats expressed high levels of the pro-inflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha and the increase in interleukin-1beta and interleukin-6, and tumor necrosis factor-alpha levels was prevented by MK-801 pre-treatment at both the protein and mRNA levels. Morphine 0-8 interleukin 1 beta Rattus norvegicus 165-182 22007590-9 2011 CONCLUSION: Acupuncture can down-regulate the expression of IL-1beta and TNF-alpha in osteoarthritic chondrocytes, and the regulating effect is the same as Diclofenac. Diclofenac 156-166 interleukin 1 beta Rattus norvegicus 60-68 21411230-10 2011 However, CIC stress enhanced the acute induction of the pro-inflammatory cytokines, IL1beta and particularly IL6, and the chemokines, CXCL1 and MCP-1, in plasma, hypothalamus and prefrontal cortex in response to LPS, and also sensitized the hypothalamic IL1beta response to acute footshock. CHVP protocol 9-12 interleukin 1 beta Rattus norvegicus 84-91 21411230-10 2011 However, CIC stress enhanced the acute induction of the pro-inflammatory cytokines, IL1beta and particularly IL6, and the chemokines, CXCL1 and MCP-1, in plasma, hypothalamus and prefrontal cortex in response to LPS, and also sensitized the hypothalamic IL1beta response to acute footshock. CHVP protocol 9-12 interleukin 1 beta Rattus norvegicus 254-261 21764125-9 2011 Additionally, hydrogen-rich saline treatment decreased the blood and placental MDA, proteinuria and the pro-inflammatory cytokine TNF-alpha, IL-1beta in the placental tissues compared with those in L-NAME-treated rats (all P < 0.05). Hydrogen 14-22 interleukin 1 beta Rattus norvegicus 141-149 21764125-9 2011 Additionally, hydrogen-rich saline treatment decreased the blood and placental MDA, proteinuria and the pro-inflammatory cytokine TNF-alpha, IL-1beta in the placental tissues compared with those in L-NAME-treated rats (all P < 0.05). Sodium Chloride 28-34 interleukin 1 beta Rattus norvegicus 141-149 21605631-8 2011 Administration of desipramine (a norepinephrine reuptake inhibitor) to Sprague-Dawley rats was sufficient either alone or in combination with stress to increase IL-1beta mRNA in the hypothalamus and desipramine combined with stress was sufficient to increase IL-1R2 mRNA in the hypothalamus. Desipramine 18-29 interleukin 1 beta Rattus norvegicus 161-169 21876380-9 2011 The administration of SRG consistently significantly alleviated memory-associated decreases in cholinergic immunoreactivity and decreased interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) mRNA expression in the hippocampus. syringaresinol-4''-O-glucoside 22-25 interleukin 1 beta Rattus norvegicus 138-155 21354353-7 2011 Treatment with curcumin also resulted in significant reduction in serum and tissue level of TNF-alpha, IL-1beta, IL-12, IL-18 and INF-gamma that were increased by renal I/R injury (p<0.05). Curcumin 15-23 interleukin 1 beta Rattus norvegicus 103-111 21487676-2 2011 Exposure of insulin-producing RINm5F cells to IL-1beta generated NO, while exposure to a combination of IL-1beta, TNF-alpha, and IFN-gamma, which simulates T1DM conditions, generated both NO and ROS. Reactive Oxygen Species 195-198 interleukin 1 beta Rattus norvegicus 104-112 21531147-9 2011 The toxic effects of IL-1beta towards cell viability, caspase activation and iNOS activity were dependent on nitric oxide and abolished by an iNOS blocker. Nitric Oxide 109-121 interleukin 1 beta Rattus norvegicus 21-29 21531147-15 2011 The deleterious effects on cell viability and function are crucially dependent on IL-1beta-induced nitric oxide formation. Nitric Oxide 99-111 interleukin 1 beta Rattus norvegicus 82-90 21617123-5 2011 Treatment with nilotinib also significantly decreased renal cortical expression of profibrogenic genes, such as IL-1beta and monocyte chemotactic protein-1, which correlated closely with the tubulointerstitial damage score and ED1-positive macrophages score. nilotinib 15-24 interleukin 1 beta Rattus norvegicus 112-120 21745392-7 2011 Similarly, the full mixture (and to a lesser degree PCBs alone) elevated levels of the pro-inflammatory cytokine, IL-1b, as well as the anti-inflammatory cytokine, IL-10. Polychlorinated Biphenyls 52-56 interleukin 1 beta Rattus norvegicus 114-119 21574020-10 2011 The results from immunohistochemical staining demonstrated that NAC suppressed the expression of IL-1beta and TNF-alpha in the periodontal ligament tissues compared to the vehicle-treated group. Acetylcysteine 64-67 interleukin 1 beta Rattus norvegicus 97-105 22066456-9 2011 Tet can inhibit the elevation of cytosolic free calcium of rat satellite cell and decrease the mRNA and protein levels of NF-kappaB and the mRNA levels of IL-1beta. tet 0-3 interleukin 1 beta Rattus norvegicus 155-163 22066456-10 2011 CONCLUSION: Via preventing Ca2+ influxion, Tet inhibited NF-kappaB activation of satellite cell which decreased IL-1beta expression. tet 43-46 interleukin 1 beta Rattus norvegicus 112-120 20371087-7 2011 VSMC released increasing levels of active MMP-2 in a dose-response fashion at IL-1beta 1-10 ng/mL (P < 0.05) while significantly increased levels of latent MMP-2 (pro-MMP-2) were attained more gradually (10 ng/mL, P < 0.05). vsmc 0-4 interleukin 1 beta Rattus norvegicus 78-86 21713382-9 2011 The concentration of IL-1beta was reduced by 53.1% by the racemic form, 30.6% by the S(+) and 43.2% by the R(-) enantiomer of ibuprofen. Ibuprofen 126-135 interleukin 1 beta Rattus norvegicus 21-29 22146222-8 2011 Hydrogen saline decreased 8-hydroxyl-2"-deoxyguanosine (8-OHdG), reduced malondidehyde, interleukin-1beta, tumor necrosis factor-alpha, and suppressed caspase 3 activity in the ischemic brain. hydrogen saline 0-15 interleukin 1 beta Rattus norvegicus 88-134 21410460-8 2011 TEA injected 4 h after surgery attenuated the increased NOS-2 expression, reduced plasma NO(x) , lung myeloperoxidase activity, levels of TNF-alpha and IL-1beta, urea, creatinine and lactate levels, prevented development of hypotension and hyporesponsiveness to phenylephrine, the alterations in plasma glucose and reduced late mortality by 50%. Tetraethylammonium 0-3 interleukin 1 beta Rattus norvegicus 152-160 21439372-3 2011 Oral administration of resveratrol to diabetic rats showed a significant normalization on the levels of creatinine clearance, plasma adiponectin, C-peptide and renal superoxide anion, hydroxyl radical, nitric oxide, TNF-alpha, IL-1beta, IL-6 and NF-kappaB p65 subunit and activities of renal aspartate transaminase, alanine transaminase and alkaline phosphatase in comparison with diabetic rats. Resveratrol 23-34 interleukin 1 beta Rattus norvegicus 227-235 21461920-6 2011 At transcriptional stage, LPS upregulated mRNA levels of cyclooxygenase-2 and IL-6 with downregulation in IL-1alpha, IL-1beta, and microsomal prostaglandin E synthase-1 (mPGES-1) through activating NF-kB translocation. lps 26-29 interleukin 1 beta Rattus norvegicus 117-125 21461920-8 2011 Treatment with nimesulide also attenuated LPS-induced Ca(2+) ion, iNOS, NF-kB, and c-fos expressions, but does not significantly influence CHOP, c-jun protein expressions, and mRNA levels of IL-6, IL-1alpha, IL-1beta, and mPGES-1 genes. nimesulide 15-25 interleukin 1 beta Rattus norvegicus 208-216 20639273-6 2011 Co-treated with ostensibly ineffectual doses of Cd and LPS had higher levels of aspartate aminotransferase and alanine aminotransferase, hepatic lipid peroxidation, peroxynitrite, nitrite, and interleukin-1beta (IL-1beta), but lower levels of hepatic metallothionein (MT) than did that treated with saline only, Cd only, and LPS only. Cadmium 48-50 interleukin 1 beta Rattus norvegicus 193-210 21536024-7 2011 In addition, minocyline treatment reduced the levels of interleukin-1beta and tumor necrosis factor-alpha, lipid peroxidation, nitrite and also improved antioxidant defense in spinal cords of diabetic rats as compared to diabetic control animals. minocyline 13-23 interleukin 1 beta Rattus norvegicus 56-105 20639273-6 2011 Co-treated with ostensibly ineffectual doses of Cd and LPS had higher levels of aspartate aminotransferase and alanine aminotransferase, hepatic lipid peroxidation, peroxynitrite, nitrite, and interleukin-1beta (IL-1beta), but lower levels of hepatic metallothionein (MT) than did that treated with saline only, Cd only, and LPS only. Cadmium 48-50 interleukin 1 beta Rattus norvegicus 212-220 20639273-9 2011 Cd promotes LPS-initiated oxidative-stress-associated liver damage by increasing IL-1beta and decreasing MT levels in rats. Cadmium 0-2 interleukin 1 beta Rattus norvegicus 81-89 21458204-12 2011 TMP treatment reduced the expressions of proinflammatory cytokines TNF-alpha (28.62 vs 15.23 pg/mg protein) and IL-1beta (13.62 vs 8.24 pg/mg protein), upregulated the expression of anti-inflammatory cytokine IL-10 (18.35 vs 31.26 pg/mg protein), and inhibited the activation of NF-kappaB (2.78 vs 1.22) in ischemic spinal cord. tetramethylpyrazine 0-3 interleukin 1 beta Rattus norvegicus 112-120 21524691-5 2011 We observed that Scutellarin inhibited lipopolysaccharide (LPS)-induced production of proinflammatory mediators such as nitric oxide (NO), tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS), suppressed LPS-stimulated inducible nitric oxide synthase (iNOS), TNFalpha, and IL-1beta mRNA expression in rat primary microglia or BV-2 mouse microglial cell line. scutellarin 17-28 interleukin 1 beta Rattus norvegicus 179-196 21524691-5 2011 We observed that Scutellarin inhibited lipopolysaccharide (LPS)-induced production of proinflammatory mediators such as nitric oxide (NO), tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS), suppressed LPS-stimulated inducible nitric oxide synthase (iNOS), TNFalpha, and IL-1beta mRNA expression in rat primary microglia or BV-2 mouse microglial cell line. scutellarin 17-28 interleukin 1 beta Rattus norvegicus 198-206 21524691-5 2011 We observed that Scutellarin inhibited lipopolysaccharide (LPS)-induced production of proinflammatory mediators such as nitric oxide (NO), tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS), suppressed LPS-stimulated inducible nitric oxide synthase (iNOS), TNFalpha, and IL-1beta mRNA expression in rat primary microglia or BV-2 mouse microglial cell line. scutellarin 17-28 interleukin 1 beta Rattus norvegicus 323-331 21699681-11 2011 RSV reduced IL-1beta but increased TNF-alpha and IL-6 levels in the diabetic kidneys. Resveratrol 0-3 interleukin 1 beta Rattus norvegicus 12-20 21681347-0 2011 Chuanxiongzine-astragaloside IV decreases IL-1beta and Caspase-3 gene expressions in rat brain damaged by cerebral ischemia/reperfusion: a study of real-time quantitative PCR assay. tetramethylpyrazine 0-14 interleukin 1 beta Rattus norvegicus 42-50 21681347-0 2011 Chuanxiongzine-astragaloside IV decreases IL-1beta and Caspase-3 gene expressions in rat brain damaged by cerebral ischemia/reperfusion: a study of real-time quantitative PCR assay. astragaloside 15-28 interleukin 1 beta Rattus norvegicus 42-50 21681347-12 2011 The results showed that melting curves exhibited sharp peaks, and PCR product also generated prominent band with expected size in agarose gel electrophoresis, which validated the optimization of the selected primer sets of IL-1beta and Caspase-3 genes. Sepharose 130-137 interleukin 1 beta Rattus norvegicus 223-231 21681347-15 2011 However, compared to those in the model group, IL-1beta and Caspase-3 gene expressions were obviously decreased in AST IV, chuanxiongzine-AST IV and nimodipine groups. tetramethylpyrazine 123-137 interleukin 1 beta Rattus norvegicus 47-55 21681347-15 2011 However, compared to those in the model group, IL-1beta and Caspase-3 gene expressions were obviously decreased in AST IV, chuanxiongzine-AST IV and nimodipine groups. Nimodipine 149-159 interleukin 1 beta Rattus norvegicus 47-55 21682888-0 2011 Midazolam suppresses interleukin-1beta-induced interleukin-6 release from rat glial cells. Midazolam 0-9 interleukin 1 beta Rattus norvegicus 21-38 21555119-5 2011 On the contrary, CIH produced a transient 2-fold increase of ET-1 immunoreactivity at 7 days, a decrease in eNOS immunoreactivity, and a delayed but progressive increase of TNF-alpha, IL-1beta and iNOS immunoreactivity, which was not associated with changes in systemic plasma levels or immune cell invasion within the CB. cih 17-20 interleukin 1 beta Rattus norvegicus 184-192 21443890-7 2011 Metoprolol administration reduced TNF-alpha and IL-1beta levels, but increased IL-10 levels at 3, 6, 12, and 24h compared to the CME group. Metoprolol 0-10 interleukin 1 beta Rattus norvegicus 48-56 21682888-6 2011 In the present study, we investigated the effect of midazolam on IL-1beta-induced IL-6 release from C6 cells, and the mechanisms of this effect. Midazolam 52-61 interleukin 1 beta Rattus norvegicus 65-73 21682888-9 2011 RESULTS: Midazolam, but not propofol, inhibited IL-1beta-stimulated IL-6 release from C6 cells. Midazolam 9-18 interleukin 1 beta Rattus norvegicus 48-56 21682888-10 2011 The IL-1beta-stimulated levels of IL-6 were suppressed by wedelolactone (an inhibitor of IkappaB kinase), SP600125 (an inhibitor of SAPK/JNK), and JAK inhibitor I (an inhibitor of JAK 1, 2 and 3). wedelolactone 58-71 interleukin 1 beta Rattus norvegicus 4-12 21682888-10 2011 The IL-1beta-stimulated levels of IL-6 were suppressed by wedelolactone (an inhibitor of IkappaB kinase), SP600125 (an inhibitor of SAPK/JNK), and JAK inhibitor I (an inhibitor of JAK 1, 2 and 3). pyrazolanthrone 106-114 interleukin 1 beta Rattus norvegicus 4-12 21682888-12 2011 Midazolam markedly suppressed IL-1beta-stimulated STAT3 phosphorylation without affecting the phosphorylation of p38 MAP kinase, SAPK/JNK or IkappaB. Midazolam 0-9 interleukin 1 beta Rattus norvegicus 30-38 21682888-13 2011 CONCLUSION: These results strongly suggest that midazolam inhibits IL-1beta-induced IL-6 release in rat C6 glioma cells via suppression of STAT3 activation. Midazolam 48-57 interleukin 1 beta Rattus norvegicus 67-75 21698800-0 2011 [Acute effects of IL-1beta on sodium current in cortical neurons of rats]. Sodium 30-36 interleukin 1 beta Rattus norvegicus 18-26 20584203-0 2011 Neuropharmacological effects of lipoic acid and ubiquinone on the mRNA level of interleukin-1beta and acetylcholinesterase activity in rat hippocampus after seizures. Thioctic Acid 32-43 interleukin 1 beta Rattus norvegicus 80-97 20584203-0 2011 Neuropharmacological effects of lipoic acid and ubiquinone on the mRNA level of interleukin-1beta and acetylcholinesterase activity in rat hippocampus after seizures. Ubiquinone 48-58 interleukin 1 beta Rattus norvegicus 80-97 20584203-1 2011 The purpose of this study was to investigate the neuroprotective effects of lipoic acid and ubiquinone on interleukin-1beta (IL-1beta) mRNA levels and acetylcholinesterase (AChE) activities in rat hippocampus after pilocarpine-induced seizures. Thioctic Acid 76-87 interleukin 1 beta Rattus norvegicus 106-123 20584203-1 2011 The purpose of this study was to investigate the neuroprotective effects of lipoic acid and ubiquinone on interleukin-1beta (IL-1beta) mRNA levels and acetylcholinesterase (AChE) activities in rat hippocampus after pilocarpine-induced seizures. Thioctic Acid 76-87 interleukin 1 beta Rattus norvegicus 125-133 20584203-1 2011 The purpose of this study was to investigate the neuroprotective effects of lipoic acid and ubiquinone on interleukin-1beta (IL-1beta) mRNA levels and acetylcholinesterase (AChE) activities in rat hippocampus after pilocarpine-induced seizures. Ubiquinone 92-102 interleukin 1 beta Rattus norvegicus 106-123 20584203-1 2011 The purpose of this study was to investigate the neuroprotective effects of lipoic acid and ubiquinone on interleukin-1beta (IL-1beta) mRNA levels and acetylcholinesterase (AChE) activities in rat hippocampus after pilocarpine-induced seizures. Ubiquinone 92-102 interleukin 1 beta Rattus norvegicus 125-133 20584203-5 2011 Reduced IL-1beta mRNA and marked AChE activities in the hippocampus were significantly higher in rats pretreated with LA or UQ in comparison with the values of the control and seized groups. uq 124-126 interleukin 1 beta Rattus norvegicus 8-16 20584203-6 2011 Our findings strongly support the hypothesis that an increase on IL-1beta mRNA levels in hippocampus occurs during seizures induced by pilocarpine, which indicates that inflammatory process plays a crucial role in seizures pathogenic consequences. Pilocarpine 135-146 interleukin 1 beta Rattus norvegicus 65-73 21272678-13 2011 In conclusion, pretreatment with isoforskolin attenuates lipopolysaccharide-induced acute lung injury in several models, and it is involved in down-regulation of inflammatory responses and proinflammatory cytokines TNF-alpha, IL-1beta, IL-6, and IL-8. Isoforskolin 33-45 interleukin 1 beta Rattus norvegicus 226-234 21190123-5 2011 RESULTS: The administration of 120 mg/kg OMT could significantly suppress gene expressions of TLR-4 and NF-kappaB, lessen concentrations of TNF-alpha, IL-1beta and IL-6, and reduce the number of apoptotic neuronal cells in traumatic rat brain tissues by the Mann-Whitney U test (P < 0.05), but the administration of 60 mg/kg OMT could not (P > 0.05). oxymatrine 41-44 interleukin 1 beta Rattus norvegicus 151-159 21671171-7 2011 Furthermore, telmisartan administration significantly reduced serum CRP, TNF-alpha and IL-1beta levels, and elevated serum IL-10 levels. Telmisartan 13-24 interleukin 1 beta Rattus norvegicus 87-95 20498031-7 2011 Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis demonstrated that the gene expression levels of interleukin-1 beta and interleukin-6 were significantly increased at 21 days after PQ challenge compared with the controls. Paraquat 215-217 interleukin 1 beta Rattus norvegicus 132-150 21359962-16 2011 HQH treatment inhibited adriamycin-induced TNF-alpha and IL-1beta expression. Doxorubicin 24-34 interleukin 1 beta Rattus norvegicus 57-65 21440046-7 2011 Post-insult administration of minocycline for 1 week (P3-P9) attenuated the P3 HI-induced increases in numbers of activated microglia and levels of TNF-alpha and IL-1beta on P45 with concurrent changes in serotonergic outcomes. Minocycline 30-41 interleukin 1 beta Rattus norvegicus 162-170 21108488-7 2011 In IL-1beta-induced rat articular chondrocytes, berberine decreased IL-1beta-induced GAG release and NO production. Berberine 48-57 interleukin 1 beta Rattus norvegicus 3-11 21108488-7 2011 In IL-1beta-induced rat articular chondrocytes, berberine decreased IL-1beta-induced GAG release and NO production. Berberine 48-57 interleukin 1 beta Rattus norvegicus 68-76 21108488-7 2011 In IL-1beta-induced rat articular chondrocytes, berberine decreased IL-1beta-induced GAG release and NO production. Glycosaminoglycans 85-88 interleukin 1 beta Rattus norvegicus 68-76 21108488-8 2011 Meanwhile, high-dose berberine exhibited an anticatabolic effect in an IL-1beta-induced rat osteoarthritis (OA) model. Berberine 21-30 interleukin 1 beta Rattus norvegicus 71-79 21241778-4 2011 In addition, edaravone increased superoxide dismutase (SOD) levels and reduced the levels of inflammatory cytokines such as IL-1beta and TNF-alpha expression; edaravone, also suppressed glial fibrillary acidic protein (GFAP) proliferation at days 3, 7 and 30 after reperfusion. Edaravone 13-22 interleukin 1 beta Rattus norvegicus 124-132 21369693-8 2011 Administration of RPM or AG490 decreased the activity of NF-kappaB and inhibited the release of TNF-alpha, IL-1beta, and IL-6. Sirolimus 18-21 interleukin 1 beta Rattus norvegicus 107-115 21633533-8 2011 Cytokine antibody array analysis showed that GL-p treatment significantly decreased the expression levels of pro-inflammatory cytokines and chemokines, including interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha, cytokine-induced neutrophil chemoattractant-2, and monocyte chemoattractant protein-1 in the inflamed mucosa. gl-p 45-49 interleukin 1 beta Rattus norvegicus 162-184 21375533-6 2011 Behavioral deficit in ethanol-exposed pups was associated with enhanced acetylcholinesterase activity, increased oxidative-nitrosative stress, cytokine (TNF-alpha, IL-1beta and TGF-beta), nuclear factor kappa beta and caspase 3 levels in both cerebral cortex and hippocampus. Ethanol 22-29 interleukin 1 beta Rattus norvegicus 164-172 21595923-1 2011 BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA) produces a neuroinflammatory reaction in rat brain characterized by an increase in interleukin-1 beta (IL-1beta) and microglial activation. N-Methyl-3,4-methylenedioxyamphetamine 12-45 interleukin 1 beta Rattus norvegicus 136-154 21595923-1 2011 BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA) produces a neuroinflammatory reaction in rat brain characterized by an increase in interleukin-1 beta (IL-1beta) and microglial activation. N-Methyl-3,4-methylenedioxyamphetamine 12-45 interleukin 1 beta Rattus norvegicus 156-164 21595923-1 2011 BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA) produces a neuroinflammatory reaction in rat brain characterized by an increase in interleukin-1 beta (IL-1beta) and microglial activation. N-Methyl-3,4-methylenedioxyamphetamine 47-51 interleukin 1 beta Rattus norvegicus 136-154 21595923-1 2011 BACKGROUND: 3,4-Methylenedioxymethamphetamine (MDMA) produces a neuroinflammatory reaction in rat brain characterized by an increase in interleukin-1 beta (IL-1beta) and microglial activation. N-Methyl-3,4-methylenedioxyamphetamine 47-51 interleukin 1 beta Rattus norvegicus 156-164 21369693-8 2011 Administration of RPM or AG490 decreased the activity of NF-kappaB and inhibited the release of TNF-alpha, IL-1beta, and IL-6. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 25-30 interleukin 1 beta Rattus norvegicus 107-115 19482377-3 2011 Vitamin D deficient (VitD-deficient) animals showed elevated inflammatory proteins (TNFalpha, IL-1beta, IL-6, NFkappaB p65) in the brain even without injury. Vitamin D 0-9 interleukin 1 beta Rattus norvegicus 94-102 21333725-6 2011 RESULTS: Type I collagen synthesis in HSCs increased significantly under the stimulation of IL-1beta for 24h, YiGanKang could inhibit p38 expression and type I collagen synthesis, SB203580, a p38 inhibitor, can significantly reduce type I collagen synthesis. SB 203580 180-188 interleukin 1 beta Rattus norvegicus 92-100 21508281-11 2011 However, alcohol-treated animals were found to have increased pulmonary levels of IL-6, IL-1beta, IL-2, and macrophage inflammatory protein-1alpha following bilateral femoral fracture. Alcohols 9-16 interleukin 1 beta Rattus norvegicus 88-96 20705428-11 2011 HSP induction by heme was associated with decreased protein levels of myeloperoxidase and interleukin-1beta after subsequent TNBS infusion. Heme 17-21 interleukin 1 beta Rattus norvegicus 90-107 21673369-9 2011 Administration of anandamide reduced the ulcers area, generation of MDA+4-HNE and serum level of IL-1beta, and this effect was associated with the reduction in the WRS-induced decrease in gastric mucosal blood flow, mucosal DNA synthesis and SOD activity. anandamide 18-28 interleukin 1 beta Rattus norvegicus 97-105 21296062-5 2011 The transcripts of IL-1beta and IL-8, and the protein expression of TNF-alpha in rats treated with both TBCP and TRBCP were also down-regulated (P<0.05), while these proinflammatory cytokines remained unchanged in rats treated with irrelevant peptide or normal saline. tbcp 104-108 interleukin 1 beta Rattus norvegicus 19-27 21296062-5 2011 The transcripts of IL-1beta and IL-8, and the protein expression of TNF-alpha in rats treated with both TBCP and TRBCP were also down-regulated (P<0.05), while these proinflammatory cytokines remained unchanged in rats treated with irrelevant peptide or normal saline. trbcp 113-118 interleukin 1 beta Rattus norvegicus 19-27 21542970-13 2011 When compared with the LPS group, the oxygenation index, white blood cell count, the lung histopathological scores and the level of IL-6 in the LPS + yohimbine group were significantly improved at each time interval, and the concentrations of TNF-alpha and IL-1beta were also lower at 24 hours of LPS administration (all P < 0.05). Yohimbine 150-159 interleukin 1 beta Rattus norvegicus 257-265 21542970-15 2011 CONCLUSIONS: Yohimbine can inhibit TNF-alpha, IL-1beta and IL-6 overproduction and relieve the severity of pulmonary inflammation induced by endotoxin, which is maybe mediated by blockade of alpha2A AR on inflammatory cells. Yohimbine 13-22 interleukin 1 beta Rattus norvegicus 46-54 21319220-7 2011 MK801 also down regulated the hypoxia-induced expression of tumor necrosis factor-alpha, interleukin-1beta, inducible nitric oxide synthase (iNOS), and nitric oxide (NO) production by microglia which may be mediated by the NF-kappaB signaling pathway. Dizocilpine Maleate 0-5 interleukin 1 beta Rattus norvegicus 89-106 21235574-8 2011 Significantly, SCH58261 also prevented the LPS-induced recruitment of activated microglial cells and the increase in interleukin-1beta concentration in the hippocampus, indicating that A2AR activation is a pivotal step in mediating the neuroinflammation triggered by LPS. 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine 15-23 interleukin 1 beta Rattus norvegicus 117-134 21244430-0 2011 Unmasking of LPA1 receptor-mediated migration response to lysophosphatidic acid by interleukin-1beta-induced attenuation of Rho signaling pathways in rat astrocytes. lysophosphatidic acid 58-79 interleukin 1 beta Rattus norvegicus 83-100 21244430-2 2011 While LPA exerted no significant effect on the cell migration, the prior treatment of the cells with LPS or IL-1beta resulted in the appearance of migration activity in response to LPA. lysophosphatidic acid 181-184 interleukin 1 beta Rattus norvegicus 108-116 21244430-3 2011 The LPS induction of the migration response to LPA was associated with the production of IL-1beta precursor protein and inhibited by the IL-1 receptor antagonist. lysophosphatidic acid 47-50 interleukin 1 beta Rattus norvegicus 89-97 21244430-4 2011 The IL-1beta treatment also allowed LPA to activate Rac1. lysophosphatidic acid 36-39 interleukin 1 beta Rattus norvegicus 4-12 21244430-7 2011 The induction of the migration response to LPA by IL-1beta was inhibited by a constitutively active RhoA. lysophosphatidic acid 43-46 interleukin 1 beta Rattus norvegicus 50-58 21542970-12 2011 The level of norepinephrine in BALF was increased at each time interval in the LPS + yohimbine group, and so did the levels of TNF-alpha, IL-1beta and IL-6 at 6 and 48 hours after LPS administration respectively. Norepinephrine 13-27 interleukin 1 beta Rattus norvegicus 138-146 21200321-8 2011 Hydrogen-rich saline treatment significantly reduced the level of degraded myelin basic protein, decreased the expression of ionized calcium-binding adapter molecule 1, Iba1, a microglial marker, reduced DNA oxidation, and suppressed proinflammatory cytokine interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in the cortex and hippocampal tissues when compared with those in normal saline-treated rats. Hydrogen 0-8 interleukin 1 beta Rattus norvegicus 259-276 21394197-10 2011 Functional significance was demonstrated by prostaglandin E2 (PGE(2)) release 4 hours after stimulation with IL-1beta, which could be aborted by a selective COX-2 (parecoxib) and a non-selective COX-inhibitor (indomethacin). parecoxib 164-173 interleukin 1 beta Rattus norvegicus 109-117 21399909-0 2011 Acute cocaine increases interleukin-1beta mRNA and immunoreactive cells in the cortex and nucleus accumbens. Cocaine 6-13 interleukin 1 beta Rattus norvegicus 24-41 21399909-3 2011 First, IL1beta mRNA levels were measured at the start or end of the light period after saline or acute exposure to a low dose of cocaine (5 mg/kg, intraperitoneal (ip)). Sodium Chloride 87-93 interleukin 1 beta Rattus norvegicus 7-14 21399909-3 2011 First, IL1beta mRNA levels were measured at the start or end of the light period after saline or acute exposure to a low dose of cocaine (5 mg/kg, intraperitoneal (ip)). Cocaine 129-136 interleukin 1 beta Rattus norvegicus 7-14 21399909-4 2011 IL1beta mRNA levels after an acute exposure to cocaine (5 mg/kg, ip) at dark onset were significantly higher than those obtained from rats sacrificed after an acute exposure to saline in the piriform and somatosensory cortex, and nucleus accumbens. Cocaine 47-54 interleukin 1 beta Rattus norvegicus 0-7 21399909-5 2011 Acute exposure of cocaine at 5 mg/kg at dark onset also increased the number of IL1beta-immunoreactive astrocytes in layer I-V of the prefrontal cortex, somatosensory cortex and nucleus accumbens. Cocaine 18-25 interleukin 1 beta Rattus norvegicus 80-87 21399909-6 2011 These data suggest that IL1beta mRNA and protein levels in some of the dopaminergically innervated brain regions are responsive to cocaine. Cocaine 131-138 interleukin 1 beta Rattus norvegicus 24-31 21394197-0 2011 IL-1beta stimulates COX-2 dependent PGE2 synthesis and CGRP release in rat trigeminal ganglia cells. Dinoprostone 36-40 interleukin 1 beta Rattus norvegicus 0-8 21185827-5 2011 IL-1beta induced COX-2 expression in RASMCs, which was inhibited by docetaxel (5-20microg/ml) in a concentration-dependent manner. rasmcs 37-43 interleukin 1 beta Rattus norvegicus 0-8 21185827-5 2011 IL-1beta induced COX-2 expression in RASMCs, which was inhibited by docetaxel (5-20microg/ml) in a concentration-dependent manner. Docetaxel 68-77 interleukin 1 beta Rattus norvegicus 0-8 21185827-7 2011 IL-1beta-induced COX-2 expression level was markedly augmented at 24h after washing out docetaxel from the culture medium. Docetaxel 88-97 interleukin 1 beta Rattus norvegicus 0-8 21185827-8 2011 Immunocytochemical analysis revealed that COX-2 immunoreactivity in RASMCs stimulated with IL-1beta was decreased in the presence of docetaxel but was recovered at 24h after washing out docetaxel, while docetaxel-induced change in tubulin formation, namely, polymerization of alpha-tubulin fibers, remained at 24h after washing out docetaxel. rasmcs 68-74 interleukin 1 beta Rattus norvegicus 91-99 21185827-8 2011 Immunocytochemical analysis revealed that COX-2 immunoreactivity in RASMCs stimulated with IL-1beta was decreased in the presence of docetaxel but was recovered at 24h after washing out docetaxel, while docetaxel-induced change in tubulin formation, namely, polymerization of alpha-tubulin fibers, remained at 24h after washing out docetaxel. Docetaxel 133-142 interleukin 1 beta Rattus norvegicus 91-99 21185827-8 2011 Immunocytochemical analysis revealed that COX-2 immunoreactivity in RASMCs stimulated with IL-1beta was decreased in the presence of docetaxel but was recovered at 24h after washing out docetaxel, while docetaxel-induced change in tubulin formation, namely, polymerization of alpha-tubulin fibers, remained at 24h after washing out docetaxel. Docetaxel 186-195 interleukin 1 beta Rattus norvegicus 91-99 21185827-8 2011 Immunocytochemical analysis revealed that COX-2 immunoreactivity in RASMCs stimulated with IL-1beta was decreased in the presence of docetaxel but was recovered at 24h after washing out docetaxel, while docetaxel-induced change in tubulin formation, namely, polymerization of alpha-tubulin fibers, remained at 24h after washing out docetaxel. Docetaxel 186-195 interleukin 1 beta Rattus norvegicus 91-99 21185827-8 2011 Immunocytochemical analysis revealed that COX-2 immunoreactivity in RASMCs stimulated with IL-1beta was decreased in the presence of docetaxel but was recovered at 24h after washing out docetaxel, while docetaxel-induced change in tubulin formation, namely, polymerization of alpha-tubulin fibers, remained at 24h after washing out docetaxel. Docetaxel 186-195 interleukin 1 beta Rattus norvegicus 91-99 21394197-10 2011 Functional significance was demonstrated by prostaglandin E2 (PGE(2)) release 4 hours after stimulation with IL-1beta, which could be aborted by a selective COX-2 (parecoxib) and a non-selective COX-inhibitor (indomethacin). Dinoprostone 44-60 interleukin 1 beta Rattus norvegicus 109-117 21394197-10 2011 Functional significance was demonstrated by prostaglandin E2 (PGE(2)) release 4 hours after stimulation with IL-1beta, which could be aborted by a selective COX-2 (parecoxib) and a non-selective COX-inhibitor (indomethacin). Dinoprostone 62-68 interleukin 1 beta Rattus norvegicus 109-117 21394197-10 2011 Functional significance was demonstrated by prostaglandin E2 (PGE(2)) release 4 hours after stimulation with IL-1beta, which could be aborted by a selective COX-2 (parecoxib) and a non-selective COX-inhibitor (indomethacin). Indomethacin 210-222 interleukin 1 beta Rattus norvegicus 109-117 21394197-14 2011 IL-1beta induced CGRP release was blocked by parecoxib and indomethacin, but the 5-HT1B/D receptor agonist sumatriptan had no effect. parecoxib 45-54 interleukin 1 beta Rattus norvegicus 0-8 21394197-14 2011 IL-1beta induced CGRP release was blocked by parecoxib and indomethacin, but the 5-HT1B/D receptor agonist sumatriptan had no effect. Indomethacin 59-71 interleukin 1 beta Rattus norvegicus 0-8 21075106-7 2011 In both models, the neuropathy seen in the saline group was associated with decreased BDNF and an increase in IL-1beta, IL-6, NGF and GDNF in most brain regions when compared to sham group. Sodium Chloride 43-49 interleukin 1 beta Rattus norvegicus 110-118 20699198-4 2011 Rats fed with alcohol (35%) for 10 weeks showed markedly decreased tail flick latency in tail-immersion test (thermal hyperalgesia), vocalization threshold in Randall-Sellito test (mechanical hyperalgesia) and paw-withdrawal threshold in von-Frey hair test (mechanical allodynia) along with enhanced oxidative-nitrosative stress and inflammatory mediators (TNF-alpha, IL-1beta and TGF-beta1 levels). Alcohols 14-21 interleukin 1 beta Rattus norvegicus 368-376 21169864-3 2011 IL-1beta up-regulated COX-2 and mPGES-1 (protein and mRNA) and increased PGI2 and PGE2 release, without altering PGIS protein expression. Epoprostenol 73-77 interleukin 1 beta Rattus norvegicus 0-8 20656372-14 2011 Taken together, these results for the first time indicate that various GCs and various cGMP-dependent signaling pathways can modulate the activity of AP-1 and/or NF-kappaB and thus affect the expressions of IL-1beta, IL-6, and TNF-alpha, which play important roles in the development of inflammation. Cyclic GMP 87-91 interleukin 1 beta Rattus norvegicus 207-215 21169864-3 2011 IL-1beta up-regulated COX-2 and mPGES-1 (protein and mRNA) and increased PGI2 and PGE2 release, without altering PGIS protein expression. Dinoprostone 82-86 interleukin 1 beta Rattus norvegicus 0-8 21169864-5 2011 Interestingly, Ang II further enhanced IL-1beta-induced COX-2 expression and PGI2 release and concomitantly reduced IL-1beta-induced mPGES-1 expression. Epoprostenol 77-81 interleukin 1 beta Rattus norvegicus 39-47 21169864-6 2011 The AT1 receptor antagonist losartan prevented the effects of Ang II on IL-1beta-induced COX-2 or mPGES-1 expression. Losartan 28-36 interleukin 1 beta Rattus norvegicus 72-80 21169864-8 2011 Inhibition of either p38 MAPK (SB203580) or ERK1/2 (PD98059) reduced COX-2 and mPGES-1 expression in cells treated with IL-1beta or the combination of IL-1beta and Ang II. SB 203580 31-39 interleukin 1 beta Rattus norvegicus 120-128 21169864-8 2011 Inhibition of either p38 MAPK (SB203580) or ERK1/2 (PD98059) reduced COX-2 and mPGES-1 expression in cells treated with IL-1beta or the combination of IL-1beta and Ang II. SB 203580 31-39 interleukin 1 beta Rattus norvegicus 151-159 21169864-8 2011 Inhibition of either p38 MAPK (SB203580) or ERK1/2 (PD98059) reduced COX-2 and mPGES-1 expression in cells treated with IL-1beta or the combination of IL-1beta and Ang II. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 52-59 interleukin 1 beta Rattus norvegicus 120-128 21169864-8 2011 Inhibition of either p38 MAPK (SB203580) or ERK1/2 (PD98059) reduced COX-2 and mPGES-1 expression in cells treated with IL-1beta or the combination of IL-1beta and Ang II. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 52-59 interleukin 1 beta Rattus norvegicus 151-159 21035874-1 2011 Systemic administration of the beta(2)-adrenoceptor agonist clenbuterol induces expression of IL-1beta and its negative regulators, interleukin-1 receptor antagonist (IL-1ra) and the interleukin-1 type II decoy receptor (IL-1RII) in rat brain. Clenbuterol 60-71 interleukin 1 beta Rattus norvegicus 94-102 21035874-3 2011 Here we examine the impact of combined treatment with clenbuterol (0.5mg/kg) and the glucocorticoid dexamethasone (1mg/kg) on mRNA expression of IL-1beta and the IL-1beta-inducible gene iNOS, on IkappaBalpha mRNA expression and NFkappaB activation, and on mRNA expression of the anti-inflammatory molecules IL-1ra, IL-1RII, IL-10 and SOCS-3 in rat cortex, striatum and hippocampus. Clenbuterol 54-65 interleukin 1 beta Rattus norvegicus 145-153 21035874-3 2011 Here we examine the impact of combined treatment with clenbuterol (0.5mg/kg) and the glucocorticoid dexamethasone (1mg/kg) on mRNA expression of IL-1beta and the IL-1beta-inducible gene iNOS, on IkappaBalpha mRNA expression and NFkappaB activation, and on mRNA expression of the anti-inflammatory molecules IL-1ra, IL-1RII, IL-10 and SOCS-3 in rat cortex, striatum and hippocampus. Clenbuterol 54-65 interleukin 1 beta Rattus norvegicus 162-170 21035874-3 2011 Here we examine the impact of combined treatment with clenbuterol (0.5mg/kg) and the glucocorticoid dexamethasone (1mg/kg) on mRNA expression of IL-1beta and the IL-1beta-inducible gene iNOS, on IkappaBalpha mRNA expression and NFkappaB activation, and on mRNA expression of the anti-inflammatory molecules IL-1ra, IL-1RII, IL-10 and SOCS-3 in rat cortex, striatum and hippocampus. Dexamethasone 100-113 interleukin 1 beta Rattus norvegicus 145-153 21035874-3 2011 Here we examine the impact of combined treatment with clenbuterol (0.5mg/kg) and the glucocorticoid dexamethasone (1mg/kg) on mRNA expression of IL-1beta and the IL-1beta-inducible gene iNOS, on IkappaBalpha mRNA expression and NFkappaB activation, and on mRNA expression of the anti-inflammatory molecules IL-1ra, IL-1RII, IL-10 and SOCS-3 in rat cortex, striatum and hippocampus. Dexamethasone 100-113 interleukin 1 beta Rattus norvegicus 162-170 21035874-4 2011 Dexamethasone inhibited induction of IL-1beta and iNOS mRNA expression by clenbuterol in all three brain regions, without altering its ability to induce IL-1ra mRNA expression. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 37-45 21035874-4 2011 Dexamethasone inhibited induction of IL-1beta and iNOS mRNA expression by clenbuterol in all three brain regions, without altering its ability to induce IL-1ra mRNA expression. Clenbuterol 74-85 interleukin 1 beta Rattus norvegicus 37-45 21749393-5 2011 Myeloperoxidase, tumour necrosis factor-alpha and interleukin-1beta of colon tissue or serum in the rectal glycyrrhizic acid groups were markedly reduced when compared with the TNBS group, and lower than in the orally treated glycyrrhizic acid group. Glycyrrhizic Acid 107-124 interleukin 1 beta Rattus norvegicus 50-67 21247366-1 2011 BACKGROUND: Silymarin has intracellular antioxidant property and inhibits activation of nuclear factor-kappaB (NF-kappaB) in low concentrations and reduces tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6 levels, cyclooxygenase (COX), and angiogenesis. Silymarin 12-21 interleukin 1 beta Rattus norvegicus 197-214 21254154-9 2011 Eviprostat significantly suppressed the increases in prostate IL-1beta, TNF-alpha and CCL3/MIP-1alpha and prostatic and urinary CCL2/MCP-1 and CXCL1/CINC-1. eviprostat 0-10 interleukin 1 beta Rattus norvegicus 62-70 21167929-2 2011 In this study, we investigated the effect of sauchinone on IL-1beta (5 ng/ml) and IFN-gamma (100 U/ml)-induced beta-cell damage. sauchinone 45-55 interleukin 1 beta Rattus norvegicus 59-67 21247366-1 2011 BACKGROUND: Silymarin has intracellular antioxidant property and inhibits activation of nuclear factor-kappaB (NF-kappaB) in low concentrations and reduces tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6 levels, cyclooxygenase (COX), and angiogenesis. Silymarin 12-21 interleukin 1 beta Rattus norvegicus 216-224 21111721-9 2011 In addition, resveratrol treatment suppressed immunoreactivity and expression of inflammatory cytokines including IL-1beta, IL-10, TNF-alpha, and myeloperoxidase (MPO) after SCI, suggesting an anti-inflammation effect of resveratrol. Resveratrol 13-24 interleukin 1 beta Rattus norvegicus 114-122 21426644-14 2011 Edaravone may decrease the expression of GFAP and IL-1beta and reduce the number of neuronal apoptosis. Edaravone 0-9 interleukin 1 beta Rattus norvegicus 50-58 21293471-3 2011 RESULTS: Compared to low glucose (10 mmol/L), treatment with high glucose (35 mmol/L) increased the secretion of tumor necrosis factor (TNF)alpha and monocyte chemotactic protein-1 (MCP-1), but not interleukin (IL)-1beta and IL-6, in a time-dependent manner in primary cultured rat microglia. Glucose 66-73 interleukin 1 beta Rattus norvegicus 198-220 21383952-6 2011 Treatment with olmesartan attenuated the myocardial mRNA expressions of proinflammatory cytokines, [Interleukin (IL)-1beta, monocyte chemoattractant protein-1, tumor necrosis factor-alpha and interferon-gamma)] and the protein expression of tumor necrosis factor-alpha compared with that of vehicle-treated rats. olmesartan 15-25 interleukin 1 beta Rattus norvegicus 100-122 21217769-8 2011 Fluoxetine also suppressed inflammatory responses in lung tissue and inhibited the expression of the inflammatory cytokines interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), monocyte chemotactic protein (MCP-1) and intercellular adhesion molecule-1 (ICAM-1). Fluoxetine 0-10 interleukin 1 beta Rattus norvegicus 124-141 21217769-8 2011 Fluoxetine also suppressed inflammatory responses in lung tissue and inhibited the expression of the inflammatory cytokines interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), monocyte chemotactic protein (MCP-1) and intercellular adhesion molecule-1 (ICAM-1). Fluoxetine 0-10 interleukin 1 beta Rattus norvegicus 143-151 20578796-5 2011 SM produced a significant decrease in monocytic interleukin-1beta and COX-2 levels and prevented oxidant formation caused by S100b, which appeared to be mediated by inhibition of p47phox membrane translocation. Silymarin 0-2 interleukin 1 beta Rattus norvegicus 48-65 21115000-9 2011 Increased myocardial mRNA expressions of inflammatory cytokines [interleukin (IL-6), IL-1beta, tumor necrosis factor-alpha and interferon-gamma] were also suppressed by telmisartan treatment compared with vehicle-treated rats. Telmisartan 169-180 interleukin 1 beta Rattus norvegicus 85-122 21081778-7 2011 In addition, the expression of TNFalpha mRNA was increased by 2.5-fold, interleukin (IL)-1beta mRNA increased by 13-fold and IL-6 mRNA by 111-fold in the dorsal spinal cord of morphine-tolerant rats. Morphine 176-184 interleukin 1 beta Rattus norvegicus 72-94 21081778-10 2011 CONCLUSIONS: The present study demonstrates that etanercept restores the antinociceptive effect of morphine in morphine-tolerant rats by inhibition of proinflammatory cytokine TNF-alpha, IL-1beta, and IL-6 expression and spinal neuroinflammation. Morphine 99-107 interleukin 1 beta Rattus norvegicus 187-195 24648573-11 2011 The pretreatment of astrocytes with morphine (10(-3) M) before stimulation with TNF-alpha, IL-8, and IL-1beta increased by 33% (P < 0.05), decreased by 15.2% (P < 0.05), and did not change the production of TGF-beta protein, respectively. Morphine 36-44 interleukin 1 beta Rattus norvegicus 101-109 24648573-9 2011 Pretreatment with morphine suppressed induction of C3 expression at both the protein and mRNA levels in astrocytes stimulated with TNF-alpha, IL-8, and IL-1beta (P < 0.05) in a dose-dependent manner. Morphine 18-26 interleukin 1 beta Rattus norvegicus 152-160 20806320-9 2011 Interestingly, continuous ERK inhibition with PD98059, after 2 and 4 days of IL-1beta treatment, enhanced the IL-1beta anabolic effect by increasing bone nodules formed. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 46-53 interleukin 1 beta Rattus norvegicus 77-85 21183317-8 2011 The intrastriatal injection of an IL-1beta antibody (200 ng/2 mul) prevented the facilitation of GA-induced seizures by LPS. glutaric acid 97-99 interleukin 1 beta Rattus norvegicus 34-42 20806320-9 2011 Interestingly, continuous ERK inhibition with PD98059, after 2 and 4 days of IL-1beta treatment, enhanced the IL-1beta anabolic effect by increasing bone nodules formed. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 46-53 interleukin 1 beta Rattus norvegicus 110-118 21598417-11 2011 Moreover, pretreatment with AMP suppressed the expression of interleukin-1beta and NF-kB in IRI-treated rats. Adenosine Monophosphate 28-31 interleukin 1 beta Rattus norvegicus 61-78 21213400-8 2011 Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and IL-6 were higher in tMCAO-operated rats than in the sham-operated rats. tmcao 112-117 interleukin 1 beta Rattus norvegicus 57-75 20692381-4 2011 Our results showed that 30min after IL-1beta injection (2-6 mug kg-1), SP levels and Evans blue extravasation in bronchoalveolar lavage fluid were markedly increased and these responses were eliminated or largely reduced in neonatal capsaicin-treated rats. Evans Blue 85-95 interleukin 1 beta Rattus norvegicus 36-44 20692381-4 2011 Our results showed that 30min after IL-1beta injection (2-6 mug kg-1), SP levels and Evans blue extravasation in bronchoalveolar lavage fluid were markedly increased and these responses were eliminated or largely reduced in neonatal capsaicin-treated rats. Capsaicin 233-242 interleukin 1 beta Rattus norvegicus 36-44 21213400-8 2011 Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and IL-6 were higher in tMCAO-operated rats than in the sham-operated rats. tmcao 112-117 interleukin 1 beta Rattus norvegicus 77-85 21362383-11 2011 HES130/0.4 lessened the release of TNF-alpha and IL-1beta consistent with the reduction of MPO activity, and HES 130/0.4 inhibited the activity of NF-kappaB in H-I/R group. hes130 0-6 interleukin 1 beta Rattus norvegicus 49-57 20854798-4 2011 Treatment of rat mesangial cells (MC) with rapamycin dose-dependently reduced the interleukin 1beta (IL-1beta)-triggered increase in gelatinolytic levels as demonstrated by zymography. Sirolimus 43-52 interleukin 1 beta Rattus norvegicus 82-99 20854798-4 2011 Treatment of rat mesangial cells (MC) with rapamycin dose-dependently reduced the interleukin 1beta (IL-1beta)-triggered increase in gelatinolytic levels as demonstrated by zymography. Sirolimus 43-52 interleukin 1 beta Rattus norvegicus 101-109 20854798-7 2011 Surprisingly, the attenuation of MMP-9 mRNA levels by rapamycin is accompanied by a potentiation of IL-1beta-induced MMP-9 promoter activity in which the stimulatory effects by rapamycin are mainly attributed to a proximal AP-1 binding site. Sirolimus 54-63 interleukin 1 beta Rattus norvegicus 100-108 20854798-7 2011 Surprisingly, the attenuation of MMP-9 mRNA levels by rapamycin is accompanied by a potentiation of IL-1beta-induced MMP-9 promoter activity in which the stimulatory effects by rapamycin are mainly attributed to a proximal AP-1 binding site. Sirolimus 177-186 interleukin 1 beta Rattus norvegicus 100-108 22083989-6 2011 Both 1x and 3 x HE treatments decreased plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, and reduced hepatic levels of pro-inflammatory cytokines - tumor necrosis factor-alpha and interleukin-1beta - compared to CCl(4) treatment alone. Helium 16-18 interleukin 1 beta Rattus norvegicus 218-235 21720000-8 2011 Furthermore, curcumin reduced the heart weight-to-body weight ratio, area of inflammatory lesions and the myocardial protein level of NF-kappaB, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and GATA-4. Curcumin 13-21 interleukin 1 beta Rattus norvegicus 145-167 21720000-9 2011 Our results indicate that curcumin has the potential to protect against cardiac inflammation through suppression of IL-1beta, TNF-alpha, GATA-4 and NF-kappaB expresses, and may provide a novel therapeutic strategy for autoimmune myocarditis. Curcumin 26-34 interleukin 1 beta Rattus norvegicus 116-124 21362383-11 2011 HES130/0.4 lessened the release of TNF-alpha and IL-1beta consistent with the reduction of MPO activity, and HES 130/0.4 inhibited the activity of NF-kappaB in H-I/R group. Helium 0-3 interleukin 1 beta Rattus norvegicus 49-57 21716679-7 2011 RMD also inhibited diabetes-induced elevation in the levels of interleukin (IL)-1beta, IL-6, interferon-gamma and tumor necrosis factor-alpha. rmd 0-3 interleukin 1 beta Rattus norvegicus 63-85 21130693-4 2011 Quantitative real-time polymerase chain reaction showed a significant decrease in mRNA expression of interleukin-1beta, interleukin-6, tumor necrosis factor alpha, and kinin B1 receptor in animals with SE treated with lovastatin, compared with untreated animals with SE (P<0.001). Lovastatin 218-228 interleukin 1 beta Rattus norvegicus 101-118 21654060-2 2011 This pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine suppresses amyloid-beta (Abeta)1-42-induced macrophage production of nitric oxide, TNF-alpha, IL-1beta, and IL-6 in a dose-dependent fashion, an activity profile consistent with SEN1176 being a neuroinflammation inhibitor. pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine 5-51 interleukin 1 beta Rattus norvegicus 146-154 21196299-3 2011 The expression levels of TNF-alpha, IL-1beta, IL-6 and VEGF in cultured rat Muller cells were enhanced by 1 mM glyoxal. Glyoxal 111-118 interleukin 1 beta Rattus norvegicus 36-44 19939655-7 2011 The results demonstrated that CsA treatment decreases blood levels of interleukins 1alpha (IL-1alpha), 1beta (IL-1beta) and interleukin 2 (IL-2), but does not alter interleukin 6 (IL-6) and IFN-gamma levels. Cyclosporine 30-33 interleukin 1 beta Rattus norvegicus 110-118 20967881-0 2011 Astrocyte reactivity to unconjugated bilirubin requires TNF-alpha and IL-1beta receptor signaling pathways. Bilirubin 37-46 interleukin 1 beta Rattus norvegicus 70-78 20967881-2 2011 We have reported that tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta are produced by cultured neurons and mainly by glial cells exposed to unconjugated bilirubin (UCB). Bilirubin 166-175 interleukin 1 beta Rattus norvegicus 60-82 20967881-2 2011 We have reported that tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta are produced by cultured neurons and mainly by glial cells exposed to unconjugated bilirubin (UCB). ucb 177-180 interleukin 1 beta Rattus norvegicus 60-82 20967881-4 2011 The present study was designed to evaluate the role of TNF-alpha and IL-1beta signaling on astrocyte reactivity to UCB in rat cortical astrocytes. ucb 115-118 interleukin 1 beta Rattus norvegicus 69-77 21654060-2 2011 This pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine suppresses amyloid-beta (Abeta)1-42-induced macrophage production of nitric oxide, TNF-alpha, IL-1beta, and IL-6 in a dose-dependent fashion, an activity profile consistent with SEN1176 being a neuroinflammation inhibitor. Nitric Oxide 121-133 interleukin 1 beta Rattus norvegicus 146-154 21672350-7 2011 In diabetic rats, minocycline treatment decreased AQP4, VEGF, Iba-1 and IL-1beta levels and retinal oedema, and increased Kir4.1 levels. Minocycline 18-29 interleukin 1 beta Rattus norvegicus 72-80 21725497-6 2011 Attenuated TNF-Alphaalpha, IL-1Beta, Nitrotyrosine, iNOS, COX-2, and PARP expression could be detected in the EGCG treated rats. epigallocatechin gallate 110-114 interleukin 1 beta Rattus norvegicus 27-35 21157380-6 2011 Minocycline effects seemed to be region specific, that is, where there was micro-glial activation and increases in tumor necrosis factor-alpha and inter-leukin 1beta. Minocycline 0-11 interleukin 1 beta Rattus norvegicus 147-165 21949812-2 2011 First, we evaluated cytokines expression at 3 days post KA-lesion in hippocampus and found that simvastatin-treatment suppressed lesion-induced expression of interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha). Simvastatin 96-107 interleukin 1 beta Rattus norvegicus 158-180 22129743-5 2011 In the hippocampus, the examination of markers of apoptosis and inflammation revealed an increase in caspase-3 activity and DNA fragmentation as well as tumor necrosis factor alpha, interleukin-1 beta and prostaglandin E2 in Pb-exposed rats. Lead 225-227 interleukin 1 beta Rattus norvegicus 182-200 21602593-6 2011 The levels of NF-kappaB, COX-2, iNOS, IL-1beta and TNF-alpha after the STZ injection were significantly increased in the hippocampus. Streptozocin 71-74 interleukin 1 beta Rattus norvegicus 38-46 21602593-8 2011 The levels of Abeta, NF-kappaB, COX-2, iNOS, IL-1beta and TNF-alpha were significantly decreased after minocycline administration; however, minocycline had no effect on BACE1 expression. Minocycline 103-114 interleukin 1 beta Rattus norvegicus 45-53 22087754-9 2011 Examination of cervical spinal cords of untreated and ibuprofen treated HRHF rats showed increased IL-1beta, an inflammatory cytokine, in neurons. Ibuprofen 54-63 interleukin 1 beta Rattus norvegicus 99-107 19815232-7 2011 Real-time RT-PCR and Western blotting showed that pretreatment with low-dose FK506 partially inhibited AIF-1 activation as well as its inducers (IFN-gamma and IL-1beta) in these three models. Tacrolimus 77-82 interleukin 1 beta Rattus norvegicus 159-167 21208533-0 2011 The effects of medroxy progesterone acetate on the pro-inflammatory cytokines, TNF-alpha and IL-1beta in the early phase of the spinal cord injury. Medroxyprogesterone Acetate 15-43 interleukin 1 beta Rattus norvegicus 93-101 22164217-6 2011 After detection using ELISA and Western blot assays, it has also been found that propofol can not only promote the expression of Annexin A1, but also inhibit the phosphorylation level of p38 and release of inflammatory factors (IL-1beta, IL-6 and TNF-alpha) in rats with endotoxemia. Propofol 81-89 interleukin 1 beta Rattus norvegicus 228-236 20869955-7 2010 Pretreatment with osthole significantly increased in GSH, and decreased the volume of infarction, NDS, edema, MDA, MPO, IL-1beta and IL-8 compared with rats in the MCAO group at 24h after MCAO. osthol 18-25 interleukin 1 beta Rattus norvegicus 120-128 20666638-4 2011 Suppressed responsiveness of parvocellular paraventricular nucleus (pPVN) corticotropin-releasing hormone neurons, and hence the HPA axis, following IL-1beta in late pregnancy is evidently explained by presynaptic inhibition of noradrenaline release in the pPVN, owing to increased endogenous opioid peptide enkephalin production in brainstem nucleus tractus solitarii neurons. Norepinephrine 228-241 interleukin 1 beta Rattus norvegicus 149-157 21351610-0 2011 [Effect of alendronate on interleukin-1beta induced chondrocytes of rat in vitro]. Alendronate 11-22 interleukin 1 beta Rattus norvegicus 26-43 21351610-1 2011 OBJECTIVE: To investigate the feasibility of alendronate (ALN) in treating osteoarthritis (OA) by observing the effects of ALN on interleukin 1beta (IL-1beta) induced chondrocytes of rat in vitro. Alendronate 45-56 interleukin 1 beta Rattus norvegicus 130-147 21351610-1 2011 OBJECTIVE: To investigate the feasibility of alendronate (ALN) in treating osteoarthritis (OA) by observing the effects of ALN on interleukin 1beta (IL-1beta) induced chondrocytes of rat in vitro. Alendronate 45-56 interleukin 1 beta Rattus norvegicus 149-157 21351610-1 2011 OBJECTIVE: To investigate the feasibility of alendronate (ALN) in treating osteoarthritis (OA) by observing the effects of ALN on interleukin 1beta (IL-1beta) induced chondrocytes of rat in vitro. Alendronate 58-61 interleukin 1 beta Rattus norvegicus 130-147 21351610-1 2011 OBJECTIVE: To investigate the feasibility of alendronate (ALN) in treating osteoarthritis (OA) by observing the effects of ALN on interleukin 1beta (IL-1beta) induced chondrocytes of rat in vitro. Alendronate 58-61 interleukin 1 beta Rattus norvegicus 149-157 21351610-1 2011 OBJECTIVE: To investigate the feasibility of alendronate (ALN) in treating osteoarthritis (OA) by observing the effects of ALN on interleukin 1beta (IL-1beta) induced chondrocytes of rat in vitro. Alendronate 123-126 interleukin 1 beta Rattus norvegicus 130-147 21351610-1 2011 OBJECTIVE: To investigate the feasibility of alendronate (ALN) in treating osteoarthritis (OA) by observing the effects of ALN on interleukin 1beta (IL-1beta) induced chondrocytes of rat in vitro. Alendronate 123-126 interleukin 1 beta Rattus norvegicus 149-157 20601239-3 2010 To test this, high-molecular-weight hyaluronic acid was conjugated with monoclonal antibodies to the pro-inflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha in two forms of the material: viscous, non-crosslinked polymer-antibody conjugates and crosslinked, elastomeric polymer-antibody conjugates. Hyaluronic Acid 36-51 interleukin 1 beta Rattus norvegicus 128-177 20883707-8 2010 In both MTX and pair-fed rats, a decrease of hypothalamic proopiomelanocortin mRNA expression and low plasma levels of interleukin-1beta (IL-1beta) were found reflecting probably the energy deficit. Methotrexate 8-11 interleukin 1 beta Rattus norvegicus 138-146 21161038-3 2010 Intraperitoneal injection of IL-1beta (5 mug/kg) was followed by accumulation of malonic dialdehyde (end-product of lipid peroxidation) in all structures of the brain in passive rats, as well as in the hypothalamus of active animals. Malondialdehyde 81-99 interleukin 1 beta Rattus norvegicus 29-37 20573453-8 2010 RESULTS: PTX substantially suppressed the burn-induced surge in the levels of TNF-alpha, IL-1beta, and IL-6 in the rat-brain tissues. Pentoxifylline 9-12 interleukin 1 beta Rattus norvegicus 89-97 20698743-6 2010 Treatment with celecoxib in a dose of 5 mg/kg was effective in decreasing the elevated levels of IL-6, IL-1beta, TNF-alpha, PGE2 whereas it lacked any effect on TXB2 level since it had hardly any effect on COX-1 enzyme. Celecoxib 15-24 interleukin 1 beta Rattus norvegicus 103-111 20626630-10 2010 However, pioglitazone inhibited iron-induced alpha-synuclein aggregation, elevations in interleukin-1beta and interleukin-6 mRNA levels as well as increases in oxygenase-1, cyclo-oxygenase II, nitric oxide synthase and ED-1 protein levels, an indicator of activated microglia. Pioglitazone 9-21 interleukin 1 beta Rattus norvegicus 88-105 21030598-9 2010 Real-time RT-PCR and immunohistochemical analyses showed that minocycline inhibited the activity of microglia and the expression of inflammatory cytokines (e.g. IL-1beta, inducible nitric-oxide synthase, and TNF-alpha), monocyte chemoattractant protein-1, and matrix metalloproteinase-12 in microglia. Minocycline 62-73 interleukin 1 beta Rattus norvegicus 161-169 21054408-8 2010 TCHE treatment also reduced serum TNF-alpha level and synovial expression of TNF-R1, IL-6 and IL-1beta. tche 0-4 interleukin 1 beta Rattus norvegicus 94-102 21224496-7 2010 Incubation of rPaSMC with interleukin-1beta and tumor necrosis factor-alpha induced PDE3A gene expression, an effect which was inhibited by L-NIL, an antagonist of NO synthase 2, or ODQ. L-NIL 140-145 interleukin 1 beta Rattus norvegicus 26-75 21224496-7 2010 Incubation of rPaSMC with interleukin-1beta and tumor necrosis factor-alpha induced PDE3A gene expression, an effect which was inhibited by L-NIL, an antagonist of NO synthase 2, or ODQ. 1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one 182-185 interleukin 1 beta Rattus norvegicus 26-75 20626630-10 2010 However, pioglitazone inhibited iron-induced alpha-synuclein aggregation, elevations in interleukin-1beta and interleukin-6 mRNA levels as well as increases in oxygenase-1, cyclo-oxygenase II, nitric oxide synthase and ED-1 protein levels, an indicator of activated microglia. Iron 32-36 interleukin 1 beta Rattus norvegicus 88-105 20811738-5 2010 We have investigated for the first time whether the antidepressant, moclobemide (a reversible selective inhibitor of monoamine oxidase-A) has an influence on pro-inflammatory cytokines [interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha] and anti-inflammatory cytokine (IL-10) in primary rat mixed glial cell cultures stimulated by lipopolysaccharide (LPS). Moclobemide 68-79 interleukin 1 beta Rattus norvegicus 186-208 20731673-11 2010 The intramucosal concentration of proinflammatory cytokines, interleukin-1beta and cytokine-induced neutrophil chemoattractant (CINC)-2, was markedly increased in methotrexate-treated rats receiving vehicle or pepstatin A but not after E64 treatment. Methotrexate 163-175 interleukin 1 beta Rattus norvegicus 61-78 20811738-6 2010 Our results showed that moclobemide used in a wide range of concentrations diminished LPS-stimulated IL-1beta and TNF-alpha mRNAs expression in cellular extracts and remarkably reduced the levels of both pro-inflammatory cytokines in culture medium. Moclobemide 24-35 interleukin 1 beta Rattus norvegicus 101-109 20811738-9 2010 These results suggest that moclobemide exerts anti-inflammatory effect in the central nervous system because it affects the balance between pro- and anti-inflammatory cytokines (IL-1beta, TNF-alpha/IL-10) in primary mixed glial cell cultures. Moclobemide 27-38 interleukin 1 beta Rattus norvegicus 178-186 20881452-7 2010 Administration of bilirubin improved glucose control and enhanced glucose tolerance in diabetic recipients, and reduced the serum levels of inflammatory mediators including IL-1beta, TNF-alpha, soluble intercellular adhesion molecule 1, monocyte chemoattractant protein-1 and NO, and inhibited the infiltration of Kupffer cells into the islet grafts, and restored insulin-producing ability of transplanted islets. Bilirubin 18-27 interleukin 1 beta Rattus norvegicus 173-181 20736048-8 2010 In contrast, intraperitoneal RA rendered a 60%, 35% and 58% reduction of IL-1beta, IL-6 and TNFalpha mRNA levels, respectively. Tretinoin 29-31 interleukin 1 beta Rattus norvegicus 73-81 20738224-7 2010 In the rat knee osteoarthritis model, the treatment of the ethanol (70%) extracts resulted in a significant increase in the activity of superoxide dismutase, an inhibition on inducible nitric oxide synthase activity, and a decrease in the contents of interleukin-1beta and tumor necrosis factor-alpha of the rat serum. Ethanol 59-66 interleukin 1 beta Rattus norvegicus 251-300 21147611-5 2010 Furthermore, injection of IL-1beta into the cerebral-spinal fluid decreases the responses of ventilation, tidal volume, and of mean inspiratory flow to carbon dioxide. Carbon Dioxide 152-166 interleukin 1 beta Rattus norvegicus 26-34 20495845-8 2010 RESULTS: Pioglitazone effectively inhibited NO, iNOS, TNF-alpha, IL-6, IL-1beta production in LPS-stimulated microglial cells. Pioglitazone 9-21 interleukin 1 beta Rattus norvegicus 71-79 20886661-4 2010 We now investigate whether sulfatide is able to protect insulin-producing cells against the pro-apoptotic effect of interleukin-1beta, interferon-gamma and tumour necrosis factor-alpha. Sulfoglycosphingolipids 27-36 interleukin 1 beta Rattus norvegicus 116-133 20854249-7 2010 IL-1beta-induced brain endothelial expression of ICAM-1 and VCAM-1 was inhibited (80-88 %) by the proteasome inhibitor MG132 or the antioxidant caffeic acid phenethyl ester (CAPE), effects suggested to be NF-kB-dependent. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 119-124 interleukin 1 beta Rattus norvegicus 0-8 20854249-7 2010 IL-1beta-induced brain endothelial expression of ICAM-1 and VCAM-1 was inhibited (80-88 %) by the proteasome inhibitor MG132 or the antioxidant caffeic acid phenethyl ester (CAPE), effects suggested to be NF-kB-dependent. caffeic acid phenethyl ester 144-172 interleukin 1 beta Rattus norvegicus 0-8 20854249-7 2010 IL-1beta-induced brain endothelial expression of ICAM-1 and VCAM-1 was inhibited (80-88 %) by the proteasome inhibitor MG132 or the antioxidant caffeic acid phenethyl ester (CAPE), effects suggested to be NF-kB-dependent. caffeic acid phenethyl ester 174-178 interleukin 1 beta Rattus norvegicus 0-8 20854249-8 2010 IL-1beta-induced brain endothelial CXCL1 expression was partially inhibited by JNK MAP kinase or MG132 (62 or 56 %, respectively). benzyloxycarbonylleucyl-leucyl-leucine aldehyde 97-102 interleukin 1 beta Rattus norvegicus 0-8 20854249-10 2010 Similarly, IL-1beta-induced neutrophil transendothelial migration was reduced (77-89 %) by MG132, but not MAP kinase inhibitors. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 91-96 interleukin 1 beta Rattus norvegicus 11-19 21265103-7 2010 The administration of enalapril resulted in a significant downregulation of IL-1beta and IL-6 in both protein and gene level, accompany with the decrease of inflammation. Enalapril 22-31 interleukin 1 beta Rattus norvegicus 76-84 20671072-4 2010 Fenofibrate completely prevented the renal disorder characterized by severe vascular lesions, tubular damage, and glomerular sclerosis, reduced the number of ED-1-positive cells and collagen accumulation, and decreased the renal expression of interleukin-1beta, transforming growth factor beta, and monocyte chemoattractant protein 1. Fenofibrate 0-11 interleukin 1 beta Rattus norvegicus 243-260 20658311-10 2010 Ad-mIL-10 prevented IL-1beta-mediated nitric oxide production from beta cells in vitro as well as the suppression of beta cells function as determined by glucose-stimulated insulin production. Nitric Oxide 38-50 interleukin 1 beta Rattus norvegicus 20-28 21265103-1 2010 OBJECTIVE: To investigate the effects of enalapril on the expressions of IL-1beta and IL-6 in the lung of rats treated with acrolein inhalation. Enalapril 41-50 interleukin 1 beta Rattus norvegicus 73-81 20807703-9 2010 10% DMSO) 5 min before reperfusion significantly reduced the (1) histological evidence of tissue injury, (2) proinflammatory cytokine production (TNF-alpha, IL-1beta), (3) adhesion molecules (ICAM-1, P-selectin), (4) nitrotyrosine formation, (5) NF-kappaB expression, and (6) apoptosis (Bax, Bcl-2, Fas-L, and TUNEL). Dimethyl Sulfoxide 4-8 interleukin 1 beta Rattus norvegicus 157-165 21265103-1 2010 OBJECTIVE: To investigate the effects of enalapril on the expressions of IL-1beta and IL-6 in the lung of rats treated with acrolein inhalation. Acrolein 124-132 interleukin 1 beta Rattus norvegicus 73-81 21265103-8 2010 CONCLUSION: Enalapril, as a ACE inhibitor, could protect the airway from inflammation injury in acrolein-treated rats via the down-regulation of IL-1beta and IL-6 expression. Enalapril 12-21 interleukin 1 beta Rattus norvegicus 145-153 21265103-6 2010 RESULTS: Increased immunostaining, protein level and mRNA expression of IL-1beta and IL-6 were found in rat lung at 3 weeks and reached to the peak at 6 weeks post exposure to acrolein. Acrolein 176-184 interleukin 1 beta Rattus norvegicus 72-80 21265103-8 2010 CONCLUSION: Enalapril, as a ACE inhibitor, could protect the airway from inflammation injury in acrolein-treated rats via the down-regulation of IL-1beta and IL-6 expression. Acrolein 96-104 interleukin 1 beta Rattus norvegicus 145-153 20621090-3 2010 Co-administration of the selective P2X7 receptor antagonist, A-438079, or the P2X7 receptor antagonist, oATP, with carrageenan blocked the mechanical hyperalgesia induced by carrageenan and significantly reduced the increased concentration of TNF-alpha, IL-6 and CINC-1, but not of IL-1beta induced by carrageenan in the subcutaneous tissue of the rat"s hind paw. Carrageenan 115-126 interleukin 1 beta Rattus norvegicus 282-290 21355277-8 2010 Phytosterols could obviously reduce the serum IL-1beta, TNF-alpha, prostate COX-2 and 5-LOX expression and improve IL-2 level. Phytosterols 0-12 interleukin 1 beta Rattus norvegicus 46-54 21039614-5 2010 After administration of rSj16 (recombinant Sj16) in vivo, paw swelling reduced significantly and in a dose-dependent manner, the level of TNF-alpha, IL-1beta and NO decreased and IL-10 in the serum increased. rsj16 24-29 interleukin 1 beta Rattus norvegicus 149-157 20621090-5 2010 It is suggested that this essential role of P2X7 receptors in the development of carrageenan-induced mechanical hyperalgesia is mediated by an indirect sensitization of the primary afferent nociceptors dependent on the previous release of TNF-alpha, IL-6 and CINC-1, but not of IL-1beta. Carrageenan 81-92 interleukin 1 beta Rattus norvegicus 278-286 20621090-3 2010 Co-administration of the selective P2X7 receptor antagonist, A-438079, or the P2X7 receptor antagonist, oATP, with carrageenan blocked the mechanical hyperalgesia induced by carrageenan and significantly reduced the increased concentration of TNF-alpha, IL-6 and CINC-1, but not of IL-1beta induced by carrageenan in the subcutaneous tissue of the rat"s hind paw. periodate-oxidized adenosine 5'-triphosphate 104-108 interleukin 1 beta Rattus norvegicus 282-290 20880404-13 2010 CONCLUSIONS AND IMPLICATIONS: Andrographolide exhibited neuroprotective effects, with accompanying suppression of NF-kappaB and microglial activation, and reduction in the production of cytokines including TNF-alpha and IL-1beta, and pro-inflammatory factors such as PGE(2). andrographolide 30-45 interleukin 1 beta Rattus norvegicus 220-228 20643114-3 2010 Oral administration of d-pinitol (50mg/kg body weight/day) for 30 days to diabetic group of rats showed a significant elevation in the level of total protein and significant decline in the levels of blood urea, serum uric acid, creatinine and advanced glycation endproducts (AGEs) and kidney proinflammatory cytokines such as TNF-alpha, IL-1beta, IL-6, NF-kappaB p65 subunit and nitrite. pinitol 23-32 interleukin 1 beta Rattus norvegicus 337-345 20601373-9 2010 On histological analysis, thalidomide treatment lowered total myocardial collagen content and the expression of TNF-alpha, IL-1beta, ICAM-1, and VCAM-1. Thalidomide 26-37 interleukin 1 beta Rattus norvegicus 123-131 20401639-5 2010 In addition, LXA(4) ME also attenuated proinflammatory cytokines (TNF-alpha and IL-1beta) production. lipoxin A4 methyl ester 13-22 interleukin 1 beta Rattus norvegicus 80-88 20204486-11 2010 In addition, zileuton attenuated the release of TNF-alpha and IL-1beta in serum. zileuton 13-21 interleukin 1 beta Rattus norvegicus 62-70 20554014-9 2010 Further, pre-administration of BBG inhibited increased expression of the microglial marker Iba-1, phosphorylated p38 (p-p38), interleukin 1beta (IL-1beta) and GluR1 following TSS. bbg 31-34 interleukin 1 beta Rattus norvegicus 126-143 20554014-9 2010 Further, pre-administration of BBG inhibited increased expression of the microglial marker Iba-1, phosphorylated p38 (p-p38), interleukin 1beta (IL-1beta) and GluR1 following TSS. bbg 31-34 interleukin 1 beta Rattus norvegicus 145-153 20630763-1 2010 The aim of this study was to evaluate the effects of tamoxifen on tumor necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta) levels and ultrastructural changes in rats with spinal cord injury. Tamoxifen 53-62 interleukin 1 beta Rattus norvegicus 110-127 20630763-5 2010 TNF-alpha and IL-1beta levels at 6 hours were significantly lower in the tamoxifen group than in the trauma group. Tamoxifen 73-82 interleukin 1 beta Rattus norvegicus 14-22 20526589-8 2010 CsA administration resulted in significant alveolar bone resorption, as assessed by a lower bone volume and an increased number of osteoclasts, and increased serum bone-specific alkaline phosphatase, TRAP-5b, IL-1 beta, IL-6, and TNF-alpha concentrations. Cyclosporine 0-3 interleukin 1 beta Rattus norvegicus 209-218 21081804-10 2010 In pituitary-intact rats, treatment with ghrelin reduced biochemical indexes of the severity of acute pancreatitis and morphological signs of pancreatic damage, leading to faster regeneration of the pancreas reduction in serum concentration of pro-inflammatory interleukin-1beta and decrease in serum activity of amylase and lipase. Ghrelin 41-48 interleukin 1 beta Rattus norvegicus 261-278 20965840-6 2010 Na2SeO3 treatment significantly inhibited the expressions of TNF-alpha and IL-1beta and decreased the apoptosis of hippocampal neurons following cerebral IR injury (P<0.05). na2seo3 0-7 interleukin 1 beta Rattus norvegicus 75-83 20655936-0 2010 Exposure to di(n-butyl)phthalate and benzo(a)pyrene alters IL-1beta secretion and subset expression of testicular macrophages, resulting in decreased testosterone production in rats. Dibutyl Phthalate 12-32 interleukin 1 beta Rattus norvegicus 59-67 20655936-0 2010 Exposure to di(n-butyl)phthalate and benzo(a)pyrene alters IL-1beta secretion and subset expression of testicular macrophages, resulting in decreased testosterone production in rats. Benzo(a)pyrene 37-51 interleukin 1 beta Rattus norvegicus 59-67 20655936-9 2010 DBP and BaP acted additively, as demonstrated by greater IL-1beta secretion relative to each compound alone. Dibutyl Phthalate 0-3 interleukin 1 beta Rattus norvegicus 57-65 20655936-9 2010 DBP and BaP acted additively, as demonstrated by greater IL-1beta secretion relative to each compound alone. Benzo(a)pyrene 8-11 interleukin 1 beta Rattus norvegicus 57-65 20382007-6 2010 In conclusion, this study suggested that icariin can improve spatial learning and memory abilities in rats with brain dysfunction induced by LPS, an effect which may be due to decreased expressions of TNF-alpha, IL-1beta and COX-2 in the hippocampus. icariin 41-48 interleukin 1 beta Rattus norvegicus 212-220 20885979-8 2010 We found Curcumin decreased the levels of D-lactate, DAO, MPO, ICAM-1, IL-1beta and TNF-alpha, but increased the levels of IL-10 and SOD in rat models. Curcumin 9-17 interleukin 1 beta Rattus norvegicus 71-79 20686009-6 2010 RESULTS: We found that lidocaine (in a dose-dependent manner) significantly attenuated p38 MAPK activation triggered by 1 mM ATP, by inhibiting the transcription of 3 cytokine messenger RNAs and causing a decrease in their respective protein concentrations (TNF-alpha, IL-1beta, and IL-6, P < 0.05, vs. the ATP group). Lidocaine 23-32 interleukin 1 beta Rattus norvegicus 269-277 20686009-6 2010 RESULTS: We found that lidocaine (in a dose-dependent manner) significantly attenuated p38 MAPK activation triggered by 1 mM ATP, by inhibiting the transcription of 3 cytokine messenger RNAs and causing a decrease in their respective protein concentrations (TNF-alpha, IL-1beta, and IL-6, P < 0.05, vs. the ATP group). Adenosine Triphosphate 125-128 interleukin 1 beta Rattus norvegicus 269-277 20686009-7 2010 SB203580, an antagonist of P38, attenuated ATP-activated elevation in protein levels of TNF-alpha, IL-1beta, and IL-6 in the microglia. SB 203580 0-8 interleukin 1 beta Rattus norvegicus 99-107 20686009-7 2010 SB203580, an antagonist of P38, attenuated ATP-activated elevation in protein levels of TNF-alpha, IL-1beta, and IL-6 in the microglia. Adenosine Triphosphate 43-46 interleukin 1 beta Rattus norvegicus 99-107 20686009-10 2010 Lidocaine, by inhibiting the increase of intracellular calcium, also inhibited p38 MAPK activation and attenuated the production of proinflammatory cytokines (including TNF-alpha, IL-1beta, and IL-6), which were triggered by extracellular ATP in cultured rat microglia. Lidocaine 0-9 interleukin 1 beta Rattus norvegicus 180-188 20221745-9 2010 Terbutaline significantly (1) prevented delayed hypotension and reduced hepatic and renal dysfunction, (2) diminished plasma IL-1beta and nitrite/nitrate, lung iNOS expression, tissue O(2) (-) level and the infiltration of neutrophils in the lung and the liver, and (3) improved the 18-h survival rate. Terbutaline 0-11 interleukin 1 beta Rattus norvegicus 125-133 20685402-4 2010 Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression. Flavonoids 23-33 interleukin 1 beta Rattus norvegicus 164-173 20660063-9 2010 Moreover, when TNFalpha-induced secretion/production of IL-1beta from adipocytes was inhibited by the IL-1 converting enzyme (ICE-1) inhibitor II (Ac-YVAD-CMK), insulin resistance was prevented. ac-yvad 147-154 interleukin 1 beta Rattus norvegicus 56-64 20685402-4 2010 Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression. Quercetin 45-54 interleukin 1 beta Rattus norvegicus 164-173 20685402-4 2010 Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression. Genistein 56-65 interleukin 1 beta Rattus norvegicus 164-173 20685402-4 2010 Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression. quercetagetin 67-80 interleukin 1 beta Rattus norvegicus 164-173 20700770-6 2010 25HC3S reduced TNFalpha-induced inflammatory response by increasing cytoplasmic IkappaBalpha levels, decreasing NFkappaB nuclear translocation, and consequently repressing expression of NFkappaB-dependent genes, IL-1beta, TNFalpha, and TRAF1. 25-hydroxycholesterol 3-sulfate 0-6 interleukin 1 beta Rattus norvegicus 212-220 23554653-0 2010 Resveratrol prevents interleukin-1beta-induced dysfunction of pancreatic beta-cells. Resveratrol 0-11 interleukin 1 beta Rattus norvegicus 21-38 23554653-3 2010 In this research, we examined the effects of resveratrol on IL-1beta-induced beta-cell dysfunction. Resveratrol 45-56 interleukin 1 beta Rattus norvegicus 60-68 23554653-4 2010 METHODS: We first evaluated the effect of resveratrol on nitric oxide (NO) formation in RINm5F cells stimulated with IL-1beta using the Griess method. Resveratrol 42-53 interleukin 1 beta Rattus norvegicus 117-125 23554653-4 2010 METHODS: We first evaluated the effect of resveratrol on nitric oxide (NO) formation in RINm5F cells stimulated with IL-1beta using the Griess method. Nitric Oxide 57-69 interleukin 1 beta Rattus norvegicus 117-125 23554653-8 2010 Finally, we evaluated the effect of resveratrol on IL-1beta-induced inhibition of glucose-stimulated insulin secretion in freshly isolated rat pancreatic islets. Resveratrol 36-47 interleukin 1 beta Rattus norvegicus 51-59 23554653-8 2010 Finally, we evaluated the effect of resveratrol on IL-1beta-induced inhibition of glucose-stimulated insulin secretion in freshly isolated rat pancreatic islets. Glucose 82-89 interleukin 1 beta Rattus norvegicus 51-59 23554653-9 2010 RESULTS: Resveratrol significantly suppressed IL-1beta-induced NO production, a finding that correlated well with reduced levels of iNOS mRNA and protein. Resveratrol 9-20 interleukin 1 beta Rattus norvegicus 46-54 23554653-11 2010 Further analysis showed that resveratrol could prevent IL-1beta-induced inhibition of glucose-stimulated insulin secretion in rat islets. Resveratrol 29-40 interleukin 1 beta Rattus norvegicus 55-63 23554653-11 2010 Further analysis showed that resveratrol could prevent IL-1beta-induced inhibition of glucose-stimulated insulin secretion in rat islets. Glucose 86-93 interleukin 1 beta Rattus norvegicus 55-63 23554653-12 2010 CONCLUSION: In this study, we demonstrated that resveratrol could protect against pancreatic beta-cell dysfunction caused by IL-1beta. Resveratrol 48-59 interleukin 1 beta Rattus norvegicus 125-133 20648656-9 2010 However, in rats given an intraperitoneal injection of DAPT prior to LPS, Notch-1 labeling was augmented, but that of TNF-alpha and IL-1beta was reduced. dapt 55-59 interleukin 1 beta Rattus norvegicus 132-140 20352441-6 2010 RESULTS: High glucose increased the expression of IL-1beta, but decreased the expressions of GS and PEDF in retinal Muller cells. Glucose 14-21 interleukin 1 beta Rattus norvegicus 50-58 20943085-8 2010 The expressions of TNFalpha and IL-1beta mRNA and proteins in liver were significantly decreased in BD+SB203580 group compared with the BD group (q = 55.11, 98.13, 61.03 and 50.85, respectively, P < 0.01), but higher than that in control group (q = 68.89, 37.22, 182.06 and 141.38, respectively, P < 0.01). SB 203580 103-111 interleukin 1 beta Rattus norvegicus 32-40 20714435-5 2010 Our results demonstrated that intrathecal siRNA-mediated suppression of TLR4 attenuated CCI-induced mechanical allodynia and thermal hyperalgesia through inhibiting the activation of NF-kappaB p65 and production of proinflammatory cytokines (e.g., TNF-alpha and IL-1 beta). CCI 88-91 interleukin 1 beta Rattus norvegicus 262-271 20353818-7 2010 In addition, intrathecal choline, delivered either with or 30 min after gp120, reduced gp120-induced IL-1beta protein and pro-inflammatory cytokine mRNAs within the lumbar spinal cord. Choline 25-32 interleukin 1 beta Rattus norvegicus 101-109 20353818-8 2010 A second alpha7nAchR agonist, GTS-21, also significantly reversed gp120-induced mechanical allodynia and lumbar spinal cord levels of pro-inflammatory cytokine mRNAs and IL-1beta protein. 3-(2,4-dimethoxybenzylidene)anabaseine 30-36 interleukin 1 beta Rattus norvegicus 170-178 20352441-7 2010 PEDF increased the expression of GS and decreased the expression of IL-1beta in retinal Muller cells under high glucose conditions. Glucose 112-119 interleukin 1 beta Rattus norvegicus 68-76 20939479-0 2010 [Effects of melatonin on expression of bone morphogenetic protein 2 and interleukin 1beta in articular cartilage of rat with osteoarthritis]. Melatonin 12-21 interleukin 1 beta Rattus norvegicus 72-89 20446039-7 2010 The increase in serum alanine aminotransferase, asparate aminotransferase, tumor necrosis factor-alpha and IL-1beta levels caused by BDL were also significantly reduced by treatment with andrographolide. andrographolide 187-202 interleukin 1 beta Rattus norvegicus 107-115 19777321-7 2010 Minocycline prevented the MDMA-induced increase in NFkappaB activation, IL-1beta release and microglial activation in the frontal cortex and prevented the 5-HT neurotoxicity 7 days later. N-Methyl-3,4-methylenedioxyamphetamine 26-30 interleukin 1 beta Rattus norvegicus 72-80 20333650-3 2010 Oral administration of resveratrol (5 mg/kg body weight) to diabetic rats for 30 days showed a significant decline in the levels of blood glucose, glycosylated hemoglobin (HbA1c), TNF-alpha, IL-1beta, IL-6, NF-kappaB p65 unit and nitric oxide (NO) with concomitant elevation in plasma insulin. Resveratrol 23-34 interleukin 1 beta Rattus norvegicus 191-199 20127399-6 2010 Since both Dexamethasone and Salvia miltiorrhizae can reduce the contents of serum PAF, sIL-2R and IL-1 beta, mitigate the pathological changes in the small intestine, spleen and thymus and reduce the mortality rate of SAP rats, they show good therapeutic effects on SAP rats. Dexamethasone 11-24 interleukin 1 beta Rattus norvegicus 99-108 20814069-14 2010 We conclude that: (1) treatment with ghrelin exhibits therapeutic effect in caerulein-induced experimental acute pancreatitis; (2) this effect is related, at least in part, to the improvement of pancreatic blood flow, reduction in proinflammatory interleukin-1beta and stimulation of pancreatic cell proliferation. Ghrelin 37-44 interleukin 1 beta Rattus norvegicus 247-264 19777321-1 2010 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a selective 5-HT neurotoxin in rat brain which has been shown to produce acute neuroinflammation characterized by activation of microglia and release of interleukin-1beta (IL-1beta). N-Methyl-3,4-methylenedioxyamphetamine 0-33 interleukin 1 beta Rattus norvegicus 208-225 19777321-1 2010 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a selective 5-HT neurotoxin in rat brain which has been shown to produce acute neuroinflammation characterized by activation of microglia and release of interleukin-1beta (IL-1beta). N-Methyl-3,4-methylenedioxyamphetamine 0-33 interleukin 1 beta Rattus norvegicus 227-235 19777321-9 2010 This suggests that the protective mechanism of minocycline against MDMA-induced neurotoxicity in frontal cortex involves inhibition of MDMA-induced NFkappaB activation possibly through a reduction in IL-1beta signalling. Minocycline 47-58 interleukin 1 beta Rattus norvegicus 200-208 19777321-1 2010 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a selective 5-HT neurotoxin in rat brain which has been shown to produce acute neuroinflammation characterized by activation of microglia and release of interleukin-1beta (IL-1beta). N-Methyl-3,4-methylenedioxyamphetamine 35-39 interleukin 1 beta Rattus norvegicus 208-225 19777321-1 2010 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a selective 5-HT neurotoxin in rat brain which has been shown to produce acute neuroinflammation characterized by activation of microglia and release of interleukin-1beta (IL-1beta). N-Methyl-3,4-methylenedioxyamphetamine 35-39 interleukin 1 beta Rattus norvegicus 227-235 20561905-10 2010 CsA treatment noticeably reduced both the serum levels and the pancreatic mRNA expression of TNF-alpha and IL-1beta and decreased brain water and MDA contents. Cyclosporine 0-3 interleukin 1 beta Rattus norvegicus 107-115 19777321-7 2010 Minocycline prevented the MDMA-induced increase in NFkappaB activation, IL-1beta release and microglial activation in the frontal cortex and prevented the 5-HT neurotoxicity 7 days later. Minocycline 0-11 interleukin 1 beta Rattus norvegicus 72-80 20689135-5 2010 The infusion of HES130/0.4 in endotoxemic rats, especially 15 ml/kg, significantly reduced the release of plasma TNF-alpha and IL-1beta, which was consistent with the observed inhibitory effects of HES130/0.4 on NF-kappaB activation, TLR4 mRNA expression, and TLR4 protein level in monocytes. hes130 16-22 interleukin 1 beta Rattus norvegicus 127-135 20061362-8 2010 Pterostilbene decreased mucosal levels of the proinflammatory cytokines, tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-4. pterostilbene 0-13 interleukin 1 beta Rattus norvegicus 102-124 20590609-7 2010 Treatment with RSCL-0520 reduced LPS-stimulated mRNA expression of TNF-alpha, COX-2, intercellular adhesion molecule-1, interleukin (IL)-8 and IL-1beta, all regulated through NF-kappaB activation. rscl-0520 15-24 interleukin 1 beta Rattus norvegicus 143-151 20540174-8 2010 They both inhibited the increased production of prostaglandin E2 in cerebrospinal fluid and tumour necrosis factor-alpha and interleukin 1beta in stimulated whole blood induced by carrageenan. Carrageenan 180-191 interleukin 1 beta Rattus norvegicus 125-142 20438866-4 2010 The data indicated that toll-like receptor 4 (TLR4) gene expression reached its peak value earlier in retinoic acid-treated rats than in the control group, and that retinoic acid significantly decreased NF-kappaB DNA binding activity and the level of IL-1beta in the mammary gland. Tretinoin 102-115 interleukin 1 beta Rattus norvegicus 251-259 20438866-4 2010 The data indicated that toll-like receptor 4 (TLR4) gene expression reached its peak value earlier in retinoic acid-treated rats than in the control group, and that retinoic acid significantly decreased NF-kappaB DNA binding activity and the level of IL-1beta in the mammary gland. Tretinoin 165-178 interleukin 1 beta Rattus norvegicus 251-259 20238162-4 2010 Sal B also suppressed LPS-induced inducible nitric oxide synthase (iNOS), TNF-alpha, and IL-1beta mRNA expression, which was accompanied by inhibiting transcription factor NF-kappaB activation. salvianolic acid B 0-5 interleukin 1 beta Rattus norvegicus 89-97 20410836-3 2010 We studied in rats the effects of the PPARgamma agonist, pioglitazone, on the regulation of IL-1beta, IL-1ra and IL-1 receptor I (IL-1RI) expression in ischaemic brain after occlusion of the middle cerebral artery for 90 min. Pioglitazone 57-69 interleukin 1 beta Rattus norvegicus 92-100 20410836-8 2010 Pioglitazone reduced IL-1beta, but upregulated IL-1ra and increased the number of IL-1ra immunoreactive cells. Pioglitazone 0-12 interleukin 1 beta Rattus norvegicus 21-29 20332187-5 2010 Terutroban decreased cerebral mRNA transcription of interleukin-1beta, transforming growth factor-beta, and monocyte chemoattractant protein-1 after 6 weeks of dietary treatment. terutroban 0-10 interleukin 1 beta Rattus norvegicus 52-69 20238162-2 2010 Our results showed that Sal B significantly reduced the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS) induced by lipopolysaccharide (LPS) treatment in rat primary microglia in a dose-dependent manner. salvianolic acid B 24-29 interleukin 1 beta Rattus norvegicus 130-147 20587056-13 2010 The enhanced mRNA expression (B1R, IL-1beta, TNF-alpha, TRPV1) and Iba-1 immunoreactivity in the STZ spinal cord were normalized by fluorocitrate or minocycline, yet B1R binding sites were reduced by 38%. fluorocitrate 132-145 interleukin 1 beta Rattus norvegicus 35-43 20238162-2 2010 Our results showed that Sal B significantly reduced the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS) induced by lipopolysaccharide (LPS) treatment in rat primary microglia in a dose-dependent manner. salvianolic acid B 24-29 interleukin 1 beta Rattus norvegicus 149-157 20361987-0 2010 Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex. Norepinephrine 0-13 interleukin 1 beta Rattus norvegicus 65-73 20361987-3 2010 Treatment with the noradrenaline reuptake inhibitor reboxetine combined with the alpha(2)-adrenoceptor antagonist idazoxan induced expression of IL-1beta as well as its negative regulators, IL-1 receptor antagonist (IL-1ra) and IL-1 type II receptor (IL-1RII) in rat cortex. Reboxetine 52-62 interleukin 1 beta Rattus norvegicus 145-153 20361987-3 2010 Treatment with the noradrenaline reuptake inhibitor reboxetine combined with the alpha(2)-adrenoceptor antagonist idazoxan induced expression of IL-1beta as well as its negative regulators, IL-1 receptor antagonist (IL-1ra) and IL-1 type II receptor (IL-1RII) in rat cortex. Idazoxan 114-122 interleukin 1 beta Rattus norvegicus 145-153 20361987-5 2010 Moreover, administration of the brain penetrant beta(2)-adrenoceptor agonist clenbuterol induced expression of IL-1beta, IL-1ra and IL-1RII in rat brain. Clenbuterol 77-88 interleukin 1 beta Rattus norvegicus 111-119 20361987-7 2010 Induction of IL-1beta was accompanied by activation of NFkappaB and of the MAP kinase ERK, and clenbuterol also induced expression of the IL-1beta-inducible gene CINC-1. Clenbuterol 95-106 interleukin 1 beta Rattus norvegicus 138-146 20346393-0 2010 Interleukin-1beta-induced brain injury and neurobehavioral dysfunctions in juvenile rats can be attenuated by alpha-phenyl-n-tert-butyl-nitrone. phenyl-N-tert-butylnitrone 110-143 interleukin 1 beta Rattus norvegicus 0-17 20510675-5 2010 AS605240 also inhibited augmented expression of TNF-alpha and IL-1beta induced by bleomycin instillation. 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione 0-8 interleukin 1 beta Rattus norvegicus 62-70 20510675-5 2010 AS605240 also inhibited augmented expression of TNF-alpha and IL-1beta induced by bleomycin instillation. Bleomycin 82-91 interleukin 1 beta Rattus norvegicus 62-70 20346393-1 2010 Our previous study showed that perinatal exposure to interleukin-1beta (IL-1beta), an inflammatory cytokine, induces acute injury to developing white matter in the neonatal rat brain, and alpha-phenyl-n-tert-butyl-nitrone (PBN), a free radical scavenger and antioxidant, protects against IL-1beta-induced acute brain injury. phenyl-N-tert-butylnitrone 223-226 interleukin 1 beta Rattus norvegicus 53-70 20346393-1 2010 Our previous study showed that perinatal exposure to interleukin-1beta (IL-1beta), an inflammatory cytokine, induces acute injury to developing white matter in the neonatal rat brain, and alpha-phenyl-n-tert-butyl-nitrone (PBN), a free radical scavenger and antioxidant, protects against IL-1beta-induced acute brain injury. phenyl-N-tert-butylnitrone 223-226 interleukin 1 beta Rattus norvegicus 72-80 20346393-7 2010 Treatments with PBN provided lasting protection against the IL-1beta-induced brain injury and improved the associated neurological dysfunctions in juvenile rats, suggesting that prompt treatments for brain injury induced by perinatal infection/inflammation might have important long-term consequences. phenyl-N-tert-butylnitrone 16-19 interleukin 1 beta Rattus norvegicus 60-68 20395292-6 2010 In addition, miR-101 contributed to the regulation of APP in response to the proinflammatory cytokine interleukin-1beta (IL-lbeta). mir-101 13-20 interleukin 1 beta Rattus norvegicus 102-119 20363306-13 2010 These findings suggest that LPS markedly decreases P-gp-mediated ileal and biliary excretion of rhodamine123, probably by partly decreasing the expression of P-gp protein levels, likely due to increased lipid peroxidation levels through iNOS mRNA and inflammatory mediators such as IL-1beta. Rhodamine 123 96-108 interleukin 1 beta Rattus norvegicus 282-290 20222144-11 2010 Blockade of IL-1beta-stimulated HMGB1 release with the ERK inhibitor U0126 was accompanied by a downregulation of CRM1. U 0126 69-74 interleukin 1 beta Rattus norvegicus 12-20 19763723-6 2010 In vitro, muscone reversed IL-1beta-induced upregulation of IL-1beta, tumor necrosis factor alpha, cyclooxygenase 2, inducible nitric oxide synthase, matrix metalloproteinase 13, aggrecanase 2, and nitric oxide and downregulation of Col2alpha1 and aggrecan. muscone 10-17 interleukin 1 beta Rattus norvegicus 27-35 19763723-6 2010 In vitro, muscone reversed IL-1beta-induced upregulation of IL-1beta, tumor necrosis factor alpha, cyclooxygenase 2, inducible nitric oxide synthase, matrix metalloproteinase 13, aggrecanase 2, and nitric oxide and downregulation of Col2alpha1 and aggrecan. muscone 10-17 interleukin 1 beta Rattus norvegicus 60-68 19763723-6 2010 In vitro, muscone reversed IL-1beta-induced upregulation of IL-1beta, tumor necrosis factor alpha, cyclooxygenase 2, inducible nitric oxide synthase, matrix metalloproteinase 13, aggrecanase 2, and nitric oxide and downregulation of Col2alpha1 and aggrecan. Nitric Oxide 127-139 interleukin 1 beta Rattus norvegicus 27-35 19763723-7 2010 Pretreatment with muscone (6.25, 12.5, 25 mumol/L) inhibited the IL-1beta-induced phosphorylation of extracellular signal-regulated kinases 1/2 and c-Jun N-terminal kinase in a dose-dependent manner. muscone 18-25 interleukin 1 beta Rattus norvegicus 65-73 19763723-8 2010 In vivo, muscone inhibited the expression of prostaglandin E2, 6-keto-prostaglandin F1alpha, IL-1beta, and tumor necrosis factor alpha and recovered the structural distortion of the degenerative disc. muscone 9-16 interleukin 1 beta Rattus norvegicus 93-101 20931796-7 2010 HSYA could alleviate pulmonary edema, reduce acidosis, keep PaO2 from descending, inhibit inflammatory cell infiltration, inhibit rat lung TNF-alpha and ICAM-1 mRNA expression and plasma IL-6 and IL-1beta level elevation. hydroxysafflor yellow A 0-4 interleukin 1 beta Rattus norvegicus 196-204 20435353-6 2010 RESULTS: IL-1beta expression was elevated in the liver of adult and reproductive senescent females fed with the high cholesterol diet, although this was restricted to groups that were ovariectomized and not replaced with estrogen. Cholesterol 117-128 interleukin 1 beta Rattus norvegicus 9-17 20412328-6 2010 Furthermore, both HTHQ and vitamin E attenuated interleukin-1beta-induced iNOS protein expression in cultured hepatocytes, the potency of HTHQ being 10-times higher than that of vitamin E. 1-O-hexyl-2,3,5-trimethylhydroquinone 18-22 interleukin 1 beta Rattus norvegicus 48-65 20412328-6 2010 Furthermore, both HTHQ and vitamin E attenuated interleukin-1beta-induced iNOS protein expression in cultured hepatocytes, the potency of HTHQ being 10-times higher than that of vitamin E. Vitamin E 27-36 interleukin 1 beta Rattus norvegicus 48-65 20412328-6 2010 Furthermore, both HTHQ and vitamin E attenuated interleukin-1beta-induced iNOS protein expression in cultured hepatocytes, the potency of HTHQ being 10-times higher than that of vitamin E. 1-O-hexyl-2,3,5-trimethylhydroquinone 138-142 interleukin 1 beta Rattus norvegicus 48-65 20412328-6 2010 Furthermore, both HTHQ and vitamin E attenuated interleukin-1beta-induced iNOS protein expression in cultured hepatocytes, the potency of HTHQ being 10-times higher than that of vitamin E. Vitamin E 178-187 interleukin 1 beta Rattus norvegicus 48-65 20452680-5 2010 Isoproterenol (beta-AR agonist) treatment induced a time- and concentration-dependent increase of IL-1beta in cells. Isoproterenol 0-13 interleukin 1 beta Rattus norvegicus 98-106 20452680-6 2010 Both ERK1/2 and P38 MAPK inhibitor, but not PKA and JNK1/2 inhibitor abrogated isoproterenol-induced IL-1beta and IL-6 production in microglia cells. Isoproterenol 79-92 interleukin 1 beta Rattus norvegicus 101-109 20145375-11 2010 PD98059 (50 microM), a selective inhibitor of ERK pathway, inhibited the angiotensin II enhancement of IL-1beta-induced MMP-9 secretion. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 interleukin 1 beta Rattus norvegicus 103-111 20424906-6 2010 Results showed that homocysteine significantly increased proinflammatory cytokines (TNF-alpha, IL-1beta and IL-6) and chemokine CCL2 (MCP-1) in serum, hippocampus and cerebral cortex. Homocysteine 20-32 interleukin 1 beta Rattus norvegicus 95-103 20145375-8 2010 Telmisartan (10 nM), an angiotensin II type 1 receptor (AT1R) antagonist, significantly suppressed the enhancement of IL-1beta-induced MMP-9 secretion by angiotensin II, whereas PD123319 (10 nM), an angiotensin II type 2 receptor antagonist, was ineffective. Telmisartan 0-11 interleukin 1 beta Rattus norvegicus 118-126 19949838-0 2010 IL-1beta modulate the Ca(2+)-activated big-conductance K channels (BK) via reactive oxygen species in cultured rat aorta smooth muscle cells. Reactive Oxygen Species 75-98 interleukin 1 beta Rattus norvegicus 0-8 20496196-7 2010 The overexpressions of hepatic TGF-beta1, IL-1beta, IL-10, MMP-2, and TIMP-1 were suppressed by bicyclol in BSA-treated rats. bicyclol 96-104 interleukin 1 beta Rattus norvegicus 42-50 20620549-8 2010 Nitrite accumulation in the supernatants revealed that rapamycin decreased nitrite release induced by interleukin-1beta but did not affect basal or A23187-stimulated nitrite levels. Nitrites 0-7 interleukin 1 beta Rattus norvegicus 102-119 20620549-8 2010 Nitrite accumulation in the supernatants revealed that rapamycin decreased nitrite release induced by interleukin-1beta but did not affect basal or A23187-stimulated nitrite levels. Sirolimus 55-64 interleukin 1 beta Rattus norvegicus 102-119 20620549-8 2010 Nitrite accumulation in the supernatants revealed that rapamycin decreased nitrite release induced by interleukin-1beta but did not affect basal or A23187-stimulated nitrite levels. Nitrites 75-82 interleukin 1 beta Rattus norvegicus 102-119 19949838-9 2010 IL-1beta increased BK channel-dependent K(+) current and hyperpolarized ASMCs when applied for 30 min. asmcs 72-77 interleukin 1 beta Rattus norvegicus 0-8 20155318-6 2010 Pretreatment with CIG decreased the infarct area, DNA fragmentation, IL-1beta and TNF-alpha concentrations, microglia and astrocyte activation, Bax expression, and caspase-3 cleavage while increasing Bcl-2 expression. 2-AMINO-6-CHLOROPYRAZINE 18-21 interleukin 1 beta Rattus norvegicus 69-77 20112301-7 2010 GTP also decreased the inflammatory factors: Tnf, Il1b and Il6 mRNA levels, and enhanced the anti-inflammatory protein, zinc-finger protein, protein and mRNA expression. Guanosine Triphosphate 0-3 interleukin 1 beta Rattus norvegicus 50-54 19953005-8 2010 Sivelestat also induced a significant reduction in serum IL-1beta (P = 0.038) and IL-10 (P = 0.008) levels in these CLP rats. sivelestat 0-10 interleukin 1 beta Rattus norvegicus 57-65 20374443-6 2010 In highly aggressively proliferating immortalized (HAPI) cells, a rat microglial cell line, METH reduced cell viability in a concentration- and time-dependent manner and initiated the expression of interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and tumor necrosis factor alpha. Methamphetamine 92-96 interleukin 1 beta Rattus norvegicus 198-215 20374443-6 2010 In highly aggressively proliferating immortalized (HAPI) cells, a rat microglial cell line, METH reduced cell viability in a concentration- and time-dependent manner and initiated the expression of interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and tumor necrosis factor alpha. Methamphetamine 92-96 interleukin 1 beta Rattus norvegicus 217-225 20426659-8 2010 Genistein treatment also decreased the levels of the inflammatory cytokines TNF-alpha, IL-1beta and TGF-beta and led to a reduction in collagen content, a reduction in 8-OHdG levels, and complete protection against DNA damage measured in surviving rats at 28 weeks after irradiation. Genistein 0-9 interleukin 1 beta Rattus norvegicus 87-95 20412551-2 2010 High molecular weight hyaluronic acid was conjugated with monoclonal antibodies to the cytokine interleukin-1beta to create a matrix-forming polymer capable of modifying healing. Hyaluronic Acid 22-37 interleukin 1 beta Rattus norvegicus 96-113 20707201-7 2010 In addition, abnormal elevation of TNF-alpha, IL-1beta and PGE2 in serum and COX-2 expression in synovium tissues of AA rats were markedly repressed by TFO treatment. tfo 152-155 interleukin 1 beta Rattus norvegicus 46-54 20412551-5 2010 Incisional wound studies in Sprague-Dawley rats indicates that viscous hyaluronic acid solutions were immunologically active, but covalent functionalization with antibodies against tumor necrosis factor-alpha and interleukin-1beta resulted in significant reductions in the inflammatory response. Hyaluronic Acid 71-86 interleukin 1 beta Rattus norvegicus 213-230 20138164-6 2010 Moreover, Treatment with LXA(4) ME suppressed neutrophils infiltration and lipid peroxidation levels; inhibited the activation of microglia and astrocytes; reduced the expression of pro-inflammatory cytokines TNF-alpha and IL-1beta; and up-regulated the expression of anti-inflammatory cytokines IL-10 and TGF-beta1 in the ischemic brain. lipoxin A4 methyl ester 25-34 interleukin 1 beta Rattus norvegicus 223-231 20043954-3 2010 Because some cytokines are involved in the regulation of sleep, this study was designed to determine if tumor necrosis factor (TNF) and interleukin-1beta (IL-1beta), mediate daytime somnolence in the proteasome inhibitor (MG-132)-induced hemiparkinsonian rat model. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 222-228 interleukin 1 beta Rattus norvegicus 155-163 20422370-8 2010 Also, resveratrol significantly inhibited the mRNA expression of inflammatory mediators including inducible nitric oxide, tumor necrosis factor-alpha and interleukin-1beta. Resveratrol 6-17 interleukin 1 beta Rattus norvegicus 154-171 20060862-8 2010 Following IL-1beta microinjection, plasma levels of triglycerides, total cholesterol and LDL were found increased. Triglycerides 52-65 interleukin 1 beta Rattus norvegicus 10-18 20060862-8 2010 Following IL-1beta microinjection, plasma levels of triglycerides, total cholesterol and LDL were found increased. Cholesterol 73-84 interleukin 1 beta Rattus norvegicus 10-18 20043954-3 2010 Because some cytokines are involved in the regulation of sleep, this study was designed to determine if tumor necrosis factor (TNF) and interleukin-1beta (IL-1beta), mediate daytime somnolence in the proteasome inhibitor (MG-132)-induced hemiparkinsonian rat model. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 222-228 interleukin 1 beta Rattus norvegicus 136-153 20004657-9 2010 Furthermore, we found that the expression of p47phox component of NAPDH oxidase, phosphorylated nuclear factor NF-kappaB p65, tumor necrosis factor alpha and interleukin-1 beta was significantly increased in the cerebral cortex of fructose-drinking rats (P<0.001). Fructose 231-239 interleukin 1 beta Rattus norvegicus 158-176 19897563-7 2010 Both BQ-123 and bosentan prevented the development of CSE-induced emphysema, blocked the expression of ET(A) receptor, inhibited pulmonary apoptosis, inactivated MMP-2 and MMP-9 activities in the lung tissues, reduced the concentrations of inflammatory cytokines TNF-alpha and IL-1beta, and improved the biological antioxidant activity in the serum. cyclo(Trp-Asp-Pro-Val-Leu) 5-11 interleukin 1 beta Rattus norvegicus 277-285 19897563-7 2010 Both BQ-123 and bosentan prevented the development of CSE-induced emphysema, blocked the expression of ET(A) receptor, inhibited pulmonary apoptosis, inactivated MMP-2 and MMP-9 activities in the lung tissues, reduced the concentrations of inflammatory cytokines TNF-alpha and IL-1beta, and improved the biological antioxidant activity in the serum. Bosentan 16-24 interleukin 1 beta Rattus norvegicus 277-285 20114032-9 2010 The concentration of Gd-DTPA in the SAS increased in a dose-dependent manner following IL-1beta intracisternal injection. Gadolinium DTPA 21-28 interleukin 1 beta Rattus norvegicus 87-95 19795501-4 2010 In primary microglial cultures subjected to hypoxia, administration of exogenous glutamate decreased IGF-1 but increased the release of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) by the cells. Glutamic Acid 81-90 interleukin 1 beta Rattus norvegicus 180-197 19795501-4 2010 In primary microglial cultures subjected to hypoxia, administration of exogenous glutamate decreased IGF-1 but increased the release of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) by the cells. Glutamic Acid 81-90 interleukin 1 beta Rattus norvegicus 199-207 20338413-7 2010 Dietary cheese whey protein reduced DSS-induced gene expression of the inflammation markers interleukin 1beta, calprotectin, and inducible nitric oxide synthase, and diminished the clinical symptoms diarrhea and fecal blood loss. Dextran Sulfate 36-39 interleukin 1 beta Rattus norvegicus 92-109 20210857-12 2010 In addition, melatonin increased Nrf2 expression, and reduced expressions of tumor necrosis factor-alpha, IL-1beta, IL-6, IL-8, and iNOS. Melatonin 13-22 interleukin 1 beta Rattus norvegicus 106-114 19948880-12 2010 The messenger RNA expression of TNF-alpha, IL-1beta, IFN-gamma, MCP1, ICAM-1 and ET-1 was increased in DSH, which was attenuated by rosuvastatin treatment. Rosuvastatin Calcium 132-144 interleukin 1 beta Rattus norvegicus 43-51 20668581-5 2010 The levels of cytokines such as IL-1beta, IL-1, IL-6, IL-8, and TNF-alpha in rats plasma were also significantly enhanced, and level of IL-10 was obviously lowered through ethanol treatment. Ethanol 172-179 interleukin 1 beta Rattus norvegicus 32-40 20617696-5 2010 RESULT: The high dose of baicalin significantly inhibited the yeast-induced fever of rats, and decresesed IL-6, IL-1beta and TNF-alpha contents in serum, hypothalamus and CSF. baicalin 25-33 interleukin 1 beta Rattus norvegicus 112-120 20617696-7 2010 CONCLUSION: Baicalin may have obvious antipyretic effect by decreasing the increasing contents of IL-1beta and TNF-alpha in rats. baicalin 12-20 interleukin 1 beta Rattus norvegicus 98-106 19958762-5 2010 Stimulation with interleukin-1beta (IL-1beta) induced iNOS expression, which was much greater in ASMCs from G-K rats than in ASMCs from control rats. asmcs 97-102 interleukin 1 beta Rattus norvegicus 17-34 19958762-5 2010 Stimulation with interleukin-1beta (IL-1beta) induced iNOS expression, which was much greater in ASMCs from G-K rats than in ASMCs from control rats. asmcs 97-102 interleukin 1 beta Rattus norvegicus 36-44 19958762-5 2010 Stimulation with interleukin-1beta (IL-1beta) induced iNOS expression, which was much greater in ASMCs from G-K rats than in ASMCs from control rats. asmcs 125-130 interleukin 1 beta Rattus norvegicus 17-34 19958762-5 2010 Stimulation with interleukin-1beta (IL-1beta) induced iNOS expression, which was much greater in ASMCs from G-K rats than in ASMCs from control rats. asmcs 125-130 interleukin 1 beta Rattus norvegicus 36-44 19958762-6 2010 When ASMCs were stimulated with IL-1beta, the number of iNOS-immunoreactive ASMCs from G-K rats increased more prominently than did the number of such ASMCs from control rats. asmcs 5-10 interleukin 1 beta Rattus norvegicus 32-40 19958762-7 2010 IL-1beta-induced NO production was also much greater in ASMCs from G-K rats than in those from control rats. asmcs 56-61 interleukin 1 beta Rattus norvegicus 0-8 19958762-8 2010 Both IL-1beta-induced iNOS expression and NO production in ASMCs of G-K and control rats were markedly reduced in the presence of an ERK inhibitor, U0126 or PD98059. asmcs 59-64 interleukin 1 beta Rattus norvegicus 5-13 19958762-8 2010 Both IL-1beta-induced iNOS expression and NO production in ASMCs of G-K and control rats were markedly reduced in the presence of an ERK inhibitor, U0126 or PD98059. U 0126 148-153 interleukin 1 beta Rattus norvegicus 5-13 19958762-8 2010 Both IL-1beta-induced iNOS expression and NO production in ASMCs of G-K and control rats were markedly reduced in the presence of an ERK inhibitor, U0126 or PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 157-164 interleukin 1 beta Rattus norvegicus 5-13 19958762-9 2010 Both basal and IL-1beta-stimulated levels of ERK activity were significantly higher in ASMCs from G-K rats than in ASMCs from control rats. asmcs 87-92 interleukin 1 beta Rattus norvegicus 15-23 19958762-9 2010 Both basal and IL-1beta-stimulated levels of ERK activity were significantly higher in ASMCs from G-K rats than in ASMCs from control rats. asmcs 115-120 interleukin 1 beta Rattus norvegicus 15-23 20080147-0 2010 Levetiracetam inhibits interleukin-1 beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats. Levetiracetam 0-13 interleukin 1 beta Rattus norvegicus 23-41 20080147-7 2010 LEV reduced reactive gliosis and expression levels of IL-1 beta system in the hippocampus and the piriform cortex, while valproic acid did not. Levetiracetam 0-3 interleukin 1 beta Rattus norvegicus 54-63 20080147-8 2010 These findings suggest that the LEV may have, at least in part, anti-inflammatory effect, particularly against IL-1 beta system in neuroglia within epileptic brains. Levetiracetam 32-35 interleukin 1 beta Rattus norvegicus 111-120 20050970-7 2010 Furthermore, anti-IL-1beta antibodies suppressed the glutamate-induced expression of MCP-1 mRNA and protein, whereas an isotype-matched antibody exerted only minimal effects. Glutamic Acid 53-62 interleukin 1 beta Rattus norvegicus 18-26 20018257-4 2010 DMC also decreased LPS-induced TNF-alpha and IL-1beta expression at both transcriptional and protein level in a concentration-dependent manner. demethoxycurcumin 0-3 interleukin 1 beta Rattus norvegicus 45-53 19769609-10 2010 Treatment of diabetic rats with the PRRB or valsartan alone and in combination significantly reduced UACR and RIF TNF-alpha and IL-1beta levels. Valsartan 44-53 interleukin 1 beta Rattus norvegicus 128-136 19769609-11 2010 Renal expression of TNF-alpha and IL-1beta was higher in untreated diabetic rats than in control rats, but was reduced significantly following treatment with PRRB or valsartan alone and in combination. Valsartan 166-175 interleukin 1 beta Rattus norvegicus 34-42 19674055-7 2010 RESULTS: Naloxone reduced IL-1 beta synthesis and microglial activation most potently at a dose of 3.84 mg/kg. Naloxone 9-17 interleukin 1 beta Rattus norvegicus 26-35 20050970-8 2010 It is worthy of note that resveratrol, to a similar degree as SL327, down-regulated glutamate-induced IL-1beta expression and reduced the expression of MCP-1 mRNA and protein release via the inactivation of ERK1/2. Resveratrol 26-37 interleukin 1 beta Rattus norvegicus 102-110 20050970-8 2010 It is worthy of note that resveratrol, to a similar degree as SL327, down-regulated glutamate-induced IL-1beta expression and reduced the expression of MCP-1 mRNA and protein release via the inactivation of ERK1/2. Glutamic Acid 84-93 interleukin 1 beta Rattus norvegicus 102-110 20050970-9 2010 These results indicate that the activation of the MEK/ERK pathway and the consequent IL-1beta expression are essential for glutamate-stimulated MCP-1 production in the hippocampus. Glutamic Acid 123-132 interleukin 1 beta Rattus norvegicus 85-93 20118807-2 2010 Lipopolysaccharide (LPS), tumor necrosis factor-alpha, and interleukin-1beta induce expression of nitric oxide (NO) and reduce the expression of gut tight junction proteins. Nitric Oxide 98-110 interleukin 1 beta Rattus norvegicus 59-76 20350432-1 2010 OBJECTIVE: To study the possible protection of edaravone on neurons of the hippocampus after status convulsion (SC) and its effects on the expression of interleukin-1beta (IL-lbeta) in juvenile rats. Edaravone 47-56 interleukin 1 beta Rattus norvegicus 153-170 19321178-11 2010 The IL-1beta concentration in the liver was also slightly, but not significantly, lower in the curcumin group. Curcumin 95-103 interleukin 1 beta Rattus norvegicus 4-12 21170295-3 2010 Local anesthetic block with lidocaine (2%) of the masseter muscle at 10 min prior to injection of CFA into the same site significantly reduced the CFA-induced increase in GFAP, IL-1beta and P-NR1 (p<0.05, n=4/group). Lidocaine 28-37 interleukin 1 beta Rattus norvegicus 177-185 20350432-15 2010 CONCLUSIONS: Edaravone pretreatment may decrease the IL-1beta expression and neuronal apoptosis in the hippocampus. Edaravone 13-22 interleukin 1 beta Rattus norvegicus 53-61 19940033-8 2010 Paricalcitol prevented upregulated inflammatory cytokines (TNF-alpha, IL-1beta, INF-gamma) and adhesion molecules (monocyte chemoattractant protein-1, ICAM-1, VCAM-1) induced by GM. paricalcitol 0-12 interleukin 1 beta Rattus norvegicus 70-78 19799935-6 2010 Our results showed that co-infusion of naloxone (15 pg/h) with morphine not only attenuated tolerance, shifting the AD(50) from 89.2 to 11.7 microg but also inhibited the increased expression of pro-inflammatory cytokine (TNF-alpha, IL-1beta, and IL-6) caused by chronic intrathecal morphine infusion. Naloxone 39-47 interleukin 1 beta Rattus norvegicus 233-241 19799935-6 2010 Our results showed that co-infusion of naloxone (15 pg/h) with morphine not only attenuated tolerance, shifting the AD(50) from 89.2 to 11.7 microg but also inhibited the increased expression of pro-inflammatory cytokine (TNF-alpha, IL-1beta, and IL-6) caused by chronic intrathecal morphine infusion. Morphine 63-71 interleukin 1 beta Rattus norvegicus 233-241 20004705-2 2010 It has been suggested that endogenous interleukin-1beta (IL-1beta) is involved in norepinephrine (NE)-induced release of corticotropin-releasing hormone (CRH) from the paraventricular nucleus of the hypothalamus (PVN). Norepinephrine 82-96 interleukin 1 beta Rattus norvegicus 38-55 20004705-2 2010 It has been suggested that endogenous interleukin-1beta (IL-1beta) is involved in norepinephrine (NE)-induced release of corticotropin-releasing hormone (CRH) from the paraventricular nucleus of the hypothalamus (PVN). Norepinephrine 82-96 interleukin 1 beta Rattus norvegicus 57-65 20004705-6 2010 Pharmacological treatments with NE or IL-1beta elicited nitric oxide (NO) release from the PVN cultures, implying that local NO might be a candidate for modulating the action of IL-1beta. Nitric Oxide 56-68 interleukin 1 beta Rattus norvegicus 38-46 20004705-6 2010 Pharmacological treatments with NE or IL-1beta elicited nitric oxide (NO) release from the PVN cultures, implying that local NO might be a candidate for modulating the action of IL-1beta. Nitric Oxide 56-68 interleukin 1 beta Rattus norvegicus 178-186 20004705-11 2010 Moreover, we found that application of L-NNA attenuated IL-1beta-induced CRH release, indicating that NO likely mediates this process. Nitroarginine 39-44 interleukin 1 beta Rattus norvegicus 56-64 20142002-12 2010 Vessel-wall IL-1 beta was reduced only in the DOXY group at 7 days (NaCl = 26 +/- 3, LMWH = 38 +/- 17, DOXY = 6 +/- 3 pg/mg protein, n = 4-6, p < 0.05), as was the IT score versus controls (NaCl = 2.2 +/- 0.6, LMWH =1.7 +/- 0.3, DOXY = 0.8 +/- 0.20, n = 4-6, p < 0.05). Doxycycline 46-50 interleukin 1 beta Rattus norvegicus 12-21 19968753-0 2010 Reductions of acetylcholine release and nerve growth factor expression are correlated with memory impairment induced by interleukin-1beta administrations: effects of omega-3 fatty acid EPA treatment. Acetylcholine 14-27 interleukin 1 beta Rattus norvegicus 120-137 20036301-4 2010 In vivo, pretreatment of rats with different doses of FSC (25, 50 and 100 mg/kg bw) and vitamin C (100 mg/kg bw, positive control) for 15 days significantly lowered the tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) in plasma compared to the negative control group. Ascorbic Acid 88-97 interleukin 1 beta Rattus norvegicus 210-227 20036301-4 2010 In vivo, pretreatment of rats with different doses of FSC (25, 50 and 100 mg/kg bw) and vitamin C (100 mg/kg bw, positive control) for 15 days significantly lowered the tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) in plasma compared to the negative control group. Ascorbic Acid 88-97 interleukin 1 beta Rattus norvegicus 229-237 19968753-5 2010 Intracerebroventricular IL-1beta administrations produced a significant reduction in hippocampal ACh release in rats fed control diet, which was partially attenuated by mifepristone (RU 486) and completely blocked by IL-1 receptor antagonist. Acetylcholine 97-100 interleukin 1 beta Rattus norvegicus 24-32 19968753-5 2010 Intracerebroventricular IL-1beta administrations produced a significant reduction in hippocampal ACh release in rats fed control diet, which was partially attenuated by mifepristone (RU 486) and completely blocked by IL-1 receptor antagonist. Mifepristone 169-181 interleukin 1 beta Rattus norvegicus 24-32 19968753-5 2010 Intracerebroventricular IL-1beta administrations produced a significant reduction in hippocampal ACh release in rats fed control diet, which was partially attenuated by mifepristone (RU 486) and completely blocked by IL-1 receptor antagonist. Mifepristone 183-189 interleukin 1 beta Rattus norvegicus 24-32 19968753-6 2010 In eight-arm radial maze, significantly less ACh release was correlated with the memory deficits after IL-1beta administrations. Acetylcholine 45-48 interleukin 1 beta Rattus norvegicus 103-111 19968753-8 2010 E-EPA treatment significantly improved the memory, which was correlated with normalizing ACh release, and expressions of NGF and IL-1beta. eicosapentaenoic acid ethyl ester 0-5 interleukin 1 beta Rattus norvegicus 129-137 20101270-9 2010 RESULTS: Levels of GFAP, COX-2, NF-kappaB, IL-1beta and TNF-alpha were all up-regulated after permanent BCCAO, which could be significantly inhibited by minocycline. Minocycline 153-164 interleukin 1 beta Rattus norvegicus 43-51 20414574-10 2010 Peripheral blood TNFalpha, IL-1beta, IL-6, C-reactive protein, procalcitonin, leukocytes and neutrophils were lower in diabetic and non diabetics septic rats treated with simvastatin, than after saline treatment. Simvastatin 171-182 interleukin 1 beta Rattus norvegicus 27-35 20043115-6 2010 RT-PCR quantitative analysis showed that aspirin treatment reduced significantly (P<0.01) the AOM-triggered increase in mRNA levels of soluble inflammatory mediators (TNFalpha and IL-1beta) and metalloproteinases (MMP3 and MMP7). Aspirin 41-48 interleukin 1 beta Rattus norvegicus 183-191 19818755-0 2010 Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1beta-induced neurotoxicity. Norepinephrine 0-13 interleukin 1 beta Rattus norvegicus 110-118 19782127-4 2010 Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta. Curcumin 81-89 interleukin 1 beta Rattus norvegicus 31-39 19782127-4 2010 Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta. Curcumin 81-89 interleukin 1 beta Rattus norvegicus 274-282 19782127-4 2010 Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta. pyrazolanthrone 163-171 interleukin 1 beta Rattus norvegicus 31-39 19782127-4 2010 Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta. pyrrolidine dithiocarbamic acid 182-209 interleukin 1 beta Rattus norvegicus 31-39 20458900-6 2010 Compared with sham group, GFAP immunoactivity (mainly in the lamina I-II of the spinal dorsal horn), TNF-alpha mRNA and IL-1beta mRNA expression in the ipsilateral spinal cord on the CCI side in model group increased considerably (P < 0.05), while compared with model group, the expression of GFAP, TNF-alpha mRNA and IL-1beta mRNA in EA group was down-regulated remarkably (P < 0.05). CCI 183-186 interleukin 1 beta Rattus norvegicus 120-128 20458900-7 2010 CONCLUSION: EA can effectively suppress CCI-induced up-regulation of expression of spinal GFAP, TNF-alpha mRNA and IL-1beta mRNA, which may contribute to its effect in reducing mechanical allodynia and thermal hyperalgesia in neuropathic pain rats. CCI 40-43 interleukin 1 beta Rattus norvegicus 115-123 19782127-4 2010 Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 (PD98069), p38 (SB202190) and JNK (SP600125), whereas pyrrolidine dithiocarbamate (PDTC) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta. pyrrolidine dithiocarbamic acid 211-215 interleukin 1 beta Rattus norvegicus 31-39 19818755-9 2010 In parallel with its ability to increase IL-1ra and IL-1RII, noradrenaline prevented neurotoxicity in cortical primary neurons induced by conditioned medium from IL-1beta treated mixed glial cells. Norepinephrine 61-74 interleukin 1 beta Rattus norvegicus 162-170 19895668-5 2010 Mechanistically, MnCl2 significantly potentiated LPS-induced release of tumor necrosis factor-alpha and interleukin-1 beta in microglia, but not in astroglia. manganese chloride 17-22 interleukin 1 beta Rattus norvegicus 104-122 19782155-4 2010 Treatment of 3Y1 cells with PKC selective inhibitors having broad specificity, such as chelerythrine chloride and GF109203X, blocked IL-1beta/TNFalpha-dependent induction of sPLA(2)-IIA protein in a dose-dependent manner. chelerythrine 87-109 interleukin 1 beta Rattus norvegicus 133-141 19782155-4 2010 Treatment of 3Y1 cells with PKC selective inhibitors having broad specificity, such as chelerythrine chloride and GF109203X, blocked IL-1beta/TNFalpha-dependent induction of sPLA(2)-IIA protein in a dose-dependent manner. bisindolylmaleimide I 114-123 interleukin 1 beta Rattus norvegicus 133-141 20490358-5 2010 An ELISA-based cytokine array revealed that candesartan normalized elevated renal interleukin (IL) 1-beta and monocyte chemoattractant protein-1 (MCP-1) levels in OZ. candesartan 44-55 interleukin 1 beta Rattus norvegicus 82-105 20424388-4 2010 IL-1beta-induced COX-2 expression in all of the above cells was abolished in the presence of U0126, an inhibitor of extracellular signal-regulated kinases (ERK). U 0126 93-98 interleukin 1 beta Rattus norvegicus 0-8 20652060-5 2010 Sitagliptin in diabetic rats promoted a decrease in glucose, HbA1c, Total-c, and TGs accompanied by a partial prevention of insulinopenia, together, with a decrease in CRPhs and IL-1beta. Sitagliptin Phosphate 0-11 interleukin 1 beta Rattus norvegicus 178-186 20040243-7 2010 RESULTS: We found that DOXY significantly inhibits neuroinflammation in the frontal cortex, striatum and hippocampus; decreases interleukin-1Beta (IL-1Beta) and tumour necrosis factor-alpha (TNF-alpha); and augments BDNF following HI. Doxycycline 23-27 interleukin 1 beta Rattus norvegicus 128-145 20040243-7 2010 RESULTS: We found that DOXY significantly inhibits neuroinflammation in the frontal cortex, striatum and hippocampus; decreases interleukin-1Beta (IL-1Beta) and tumour necrosis factor-alpha (TNF-alpha); and augments BDNF following HI. Doxycycline 23-27 interleukin 1 beta Rattus norvegicus 147-155 20402659-10 2010 Treatment with all three drugs (tacrolimus, somatostatin and glucocorticoids) resulted in a significant decrease of serum amylase, lung edema, and serum TNF-alpha and IL-1beta levels. Tacrolimus 32-42 interleukin 1 beta Rattus norvegicus 167-175 19585485-9 2010 Furthermore, synoviocyte proliferation in AA rats was apparently suppressed after hesperidin treatment, which was accompanied by decreased transcription as well as production of TNF-alpha and IL-1beta from synoviocytes. Hesperidin 82-92 interleukin 1 beta Rattus norvegicus 192-200 19816055-0 2010 Kainic acid-activated microglia mediate increased excitability of rat hippocampal neurons in vitro and in vivo: crucial role of interleukin-1beta. Kainic Acid 0-11 interleukin 1 beta Rattus norvegicus 128-145 20722564-7 2010 Administration of trapidil diminished the renal and liver injury and significantly attenuated the levels of serum creatinine, urea, aspartate aminotransferase (AST), alanine aminotransferase (ALT), interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), and oxidative stress, while it significantly elevated the level of serum nitric oxide and the activity of antioxidative stress. Trapidil 18-26 interleukin 1 beta Rattus norvegicus 198-215 20722564-7 2010 Administration of trapidil diminished the renal and liver injury and significantly attenuated the levels of serum creatinine, urea, aspartate aminotransferase (AST), alanine aminotransferase (ALT), interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), and oxidative stress, while it significantly elevated the level of serum nitric oxide and the activity of antioxidative stress. Trapidil 18-26 interleukin 1 beta Rattus norvegicus 217-225 19818401-5 2009 Lower plasma chemokine levels as well as decreased amylasemia, hematocrit and plasma interleukin-1beta (Il-1beta) levels were found either in mild or severe AP treated with Dex. Dexamethasone 173-176 interleukin 1 beta Rattus norvegicus 85-102 19818401-5 2009 Lower plasma chemokine levels as well as decreased amylasemia, hematocrit and plasma interleukin-1beta (Il-1beta) levels were found either in mild or severe AP treated with Dex. Dexamethasone 173-176 interleukin 1 beta Rattus norvegicus 104-112 19130224-3 2009 In addition, SK-MS10 reduced increases of mucosal myeloperoxidase (MPO), IL-1beta, and TNFalpha levels and the expression of cPLA(2), and 5-LOX induced by ethanol or WRS. Ethanol 155-162 interleukin 1 beta Rattus norvegicus 73-81 20222429-14 2009 CONCLUSION: GA could inhibit the secondary inflamation of AA rats and decrease the level of TNF-alpha and IL-1beta protein in the AA rats serum. Gallium 12-14 interleukin 1 beta Rattus norvegicus 106-114 19861503-4 2009 We hypothesized that glucose-induced up-regulation of PRR leads to increased production of the proinflammatory factors IL-1beta and cyclooxygenase-2 (COX-2). Glucose 21-28 interleukin 1 beta Rattus norvegicus 119-127 19861503-6 2009 The results showed that D-glucose treatment up-regulates prorenin, renin, angiotensin II, PRR, IL-1beta, and COX-2 mRNA and protein expression and increases phosphorylation of ERK1/2, c-Jun N-terminal kinase, c-Jun, and nuclear factor-kappaB (NF-kappaB) p65 (serine 276,468 and 536), respectively. Glucose 24-33 interleukin 1 beta Rattus norvegicus 95-103 19861503-10 2009 We conclude that glucose induces the up-regulation of PRR and its ligands prorenin and renin, leading to increased IL-1beta and COX-2 production via the angiotensin II-dependent pathway. Glucose 17-24 interleukin 1 beta Rattus norvegicus 115-123 19455716-4 2009 Zymographic, Western blotting, and RT-PCR analyses showed that IL-1beta-induced expression of MMP-9 mRNA and protein was attenuated by Ca(2+) chelator (BAPTA), and the inhibitors of ER Ca(2+)-ATPase (thapsigargin), CaMKII (KN-62), and JNK1/2 (SP600125). 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid 152-157 interleukin 1 beta Rattus norvegicus 63-71 19455716-4 2009 Zymographic, Western blotting, and RT-PCR analyses showed that IL-1beta-induced expression of MMP-9 mRNA and protein was attenuated by Ca(2+) chelator (BAPTA), and the inhibitors of ER Ca(2+)-ATPase (thapsigargin), CaMKII (KN-62), and JNK1/2 (SP600125). Thapsigargin 200-212 interleukin 1 beta Rattus norvegicus 63-71 19455716-5 2009 IL-1beta also stimulated phosphorylation of CaMKII and JNK1/2, and increase in intracellular Ca(2+) ([Ca(2+)](i)), which were inhibited by pretreatment with BAPTA, thapsigargin (TG), KN-62, or SP600125. 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid 157-162 interleukin 1 beta Rattus norvegicus 0-8 19455716-5 2009 IL-1beta also stimulated phosphorylation of CaMKII and JNK1/2, and increase in intracellular Ca(2+) ([Ca(2+)](i)), which were inhibited by pretreatment with BAPTA, thapsigargin (TG), KN-62, or SP600125. Thapsigargin 164-176 interleukin 1 beta Rattus norvegicus 0-8 19455716-5 2009 IL-1beta also stimulated phosphorylation of CaMKII and JNK1/2, and increase in intracellular Ca(2+) ([Ca(2+)](i)), which were inhibited by pretreatment with BAPTA, thapsigargin (TG), KN-62, or SP600125. Thapsigargin 178-180 interleukin 1 beta Rattus norvegicus 0-8 19455716-5 2009 IL-1beta also stimulated phosphorylation of CaMKII and JNK1/2, and increase in intracellular Ca(2+) ([Ca(2+)](i)), which were inhibited by pretreatment with BAPTA, thapsigargin (TG), KN-62, or SP600125. KN 62 183-188 interleukin 1 beta Rattus norvegicus 0-8 19455716-5 2009 IL-1beta also stimulated phosphorylation of CaMKII and JNK1/2, and increase in intracellular Ca(2+) ([Ca(2+)](i)), which were inhibited by pretreatment with BAPTA, thapsigargin (TG), KN-62, or SP600125. pyrazolanthrone 193-201 interleukin 1 beta Rattus norvegicus 0-8 19710095-3 2009 Sesamol: (i) dose-dependently inhibited LPS from binding to LPS binding protein; (ii) significantly decreased the release of tumor necrosis factor-alpha and interleukin-1beta in LPS-challenged peritoneal macrophages in medium and in the serum of LPS-challenged rats; and (iii) significantly reduced the mortality rate in mice given a lethal dose of LPS. sesamol 0-7 interleukin 1 beta Rattus norvegicus 157-174 20046028-9 2009 When l-NMMA was added to the medium with IL-1beta and TNF-alpha, changes to PAR-2 by these cytokine recovered. omega-N-Methylarginine 5-11 interleukin 1 beta Rattus norvegicus 41-49 19747956-6 2009 Moreover, ghrelin inhibited the inflammatory response, as shown by decreased mRNA and protein levels of interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha). Ghrelin 10-17 interleukin 1 beta Rattus norvegicus 104-126 19464322-6 2009 From the 6th week onwards, ethanol-treated rats showed significant increase in transfer latency in both the behavioral paradigms which was coupled with enhanced acetylcholinesterase activity, increased oxidative-nitrosative stress, TNF-alpha and IL-1beta levels in different brain regions of ethanol-treated rats. Ethanol 27-34 interleukin 1 beta Rattus norvegicus 246-254 19673871-11 2009 I/R treatment increased mRNA levels of COX-2, IL-1beta, IL-6 and iNOS, which were further augmented by nicotine in a dose-dependent manner. Nicotine 103-111 interleukin 1 beta Rattus norvegicus 46-54 19627280-5 2009 In the lung, alpha-DG treatment reduced concentrations of IL-1beta by 30% (p > 0.05), IL-6 by 43% (p < 0.01), IFN-gamma by 46% (p < 0.01) and the anti-inflammatory cytokine, IL-10, by 31% (p > 0.05) compared to endotoxaemia. alpha-dg 13-21 interleukin 1 beta Rattus norvegicus 58-66 19627280-6 2009 In the spleen, alpha-DG treatment decreased the ratio of IL-1beta to IL-10 by 55% (p < 0.05), demonstrating an anti-inflammatory trend. alpha-dg 15-23 interleukin 1 beta Rattus norvegicus 57-65 19682987-0 2009 Interleukin-1beta-induced brain injury in the neonatal rat can be ameliorated by alpha-phenyl-n-tert-butyl-nitrone. phenyl-N-tert-butylnitrone 81-114 interleukin 1 beta Rattus norvegicus 0-17 19682987-6 2009 Protection of PBN was linked with the attenuated oxidative stress induced by IL-1beta, as indicated by decreased elevation of 8-isoprostane content and by the reduced number of 4-hydroxynonenal or malondialdehyde or nitrotyrosine-positive cells following IL-1beta exposure. phenyl-N-tert-butylnitrone 14-17 interleukin 1 beta Rattus norvegicus 77-85 19682987-6 2009 Protection of PBN was linked with the attenuated oxidative stress induced by IL-1beta, as indicated by decreased elevation of 8-isoprostane content and by the reduced number of 4-hydroxynonenal or malondialdehyde or nitrotyrosine-positive cells following IL-1beta exposure. phenyl-N-tert-butylnitrone 14-17 interleukin 1 beta Rattus norvegicus 255-263 19682987-6 2009 Protection of PBN was linked with the attenuated oxidative stress induced by IL-1beta, as indicated by decreased elevation of 8-isoprostane content and by the reduced number of 4-hydroxynonenal or malondialdehyde or nitrotyrosine-positive cells following IL-1beta exposure. 8-epi-prostaglandin F2alpha 126-139 interleukin 1 beta Rattus norvegicus 77-85 19682987-6 2009 Protection of PBN was linked with the attenuated oxidative stress induced by IL-1beta, as indicated by decreased elevation of 8-isoprostane content and by the reduced number of 4-hydroxynonenal or malondialdehyde or nitrotyrosine-positive cells following IL-1beta exposure. 4-hydroxy-2-nonenal 177-193 interleukin 1 beta Rattus norvegicus 77-85 19660463-8 2009 Exposure of squamous cells to acidified bile salts significantly increased the secretion of interleukin-8 and interleukin-1beta; conditioned media from these cells caused significant increases in the migration rates of T cells and neutrophils. Bile Acids and Salts 40-50 interleukin 1 beta Rattus norvegicus 110-127 19682987-6 2009 Protection of PBN was linked with the attenuated oxidative stress induced by IL-1beta, as indicated by decreased elevation of 8-isoprostane content and by the reduced number of 4-hydroxynonenal or malondialdehyde or nitrotyrosine-positive cells following IL-1beta exposure. Malondialdehyde 197-212 interleukin 1 beta Rattus norvegicus 77-85 19682987-6 2009 Protection of PBN was linked with the attenuated oxidative stress induced by IL-1beta, as indicated by decreased elevation of 8-isoprostane content and by the reduced number of 4-hydroxynonenal or malondialdehyde or nitrotyrosine-positive cells following IL-1beta exposure. 3-nitrotyrosine 216-229 interleukin 1 beta Rattus norvegicus 77-85 19682987-7 2009 PBN also attenuated IL-1beta-stimulated inflammatory responses as indicated by the reduced activation of microglia. phenyl-N-tert-butylnitrone 0-3 interleukin 1 beta Rattus norvegicus 20-28 19682987-8 2009 The finding that IL-1beta induced perinatal brain injury was very similar to that induced by lipopolysaccharide (LPS), as we previously reported and that PBN was capable to attenuate the injury induced by either LPS or IL-1beta suggests that IL-1beta may play a critical role in mediating brain injury associated with perinatal infection/inflammation. phenyl-N-tert-butylnitrone 154-157 interleukin 1 beta Rattus norvegicus 219-227 19682987-8 2009 The finding that IL-1beta induced perinatal brain injury was very similar to that induced by lipopolysaccharide (LPS), as we previously reported and that PBN was capable to attenuate the injury induced by either LPS or IL-1beta suggests that IL-1beta may play a critical role in mediating brain injury associated with perinatal infection/inflammation. phenyl-N-tert-butylnitrone 154-157 interleukin 1 beta Rattus norvegicus 219-227 19427376-5 2009 The AT(1) receptor blocker (ARB) candesartan (1mg/kg/day, s.c. daily for 3 days before LPS) blocked pituitary and PVN AT(1) receptors, inhibited LPS-induced ACTH but not corticosterone secretion and decreased LPS-induced release of TNF-alpha, IL-1beta and IL-6 to the circulation. candesartan 33-44 interleukin 1 beta Rattus norvegicus 243-251 19660546-6 2009 The increase in seizure susceptibility, glutamate receptor subunits, and hippocampal IL-1beta levels were suppressed by neonatal systemic minocycline. Minocycline 138-149 interleukin 1 beta Rattus norvegicus 85-93 21158055-6 2009 IL-1beta induced a significant decrease of cell activity and insulin release, flow cytometry analysis showed that apoptotic percentage of islet cells remarkably increased following the addition of IL-1beta, FDP obviously improved the islets cellular activity damaged by IL-1beta, and basic amount of insulin secretion and stimulated by high glucose were improved (P < 0.01). Glucose 341-348 interleukin 1 beta Rattus norvegicus 0-8 21158055-6 2009 IL-1beta induced a significant decrease of cell activity and insulin release, flow cytometry analysis showed that apoptotic percentage of islet cells remarkably increased following the addition of IL-1beta, FDP obviously improved the islets cellular activity damaged by IL-1beta, and basic amount of insulin secretion and stimulated by high glucose were improved (P < 0.01). Glucose 341-348 interleukin 1 beta Rattus norvegicus 197-205 21158055-6 2009 IL-1beta induced a significant decrease of cell activity and insulin release, flow cytometry analysis showed that apoptotic percentage of islet cells remarkably increased following the addition of IL-1beta, FDP obviously improved the islets cellular activity damaged by IL-1beta, and basic amount of insulin secretion and stimulated by high glucose were improved (P < 0.01). Glucose 341-348 interleukin 1 beta Rattus norvegicus 197-205 19849845-10 2009 RESULTS: In burned rats, 17 beta-estradiol significantly decreased the levels of brain tissue TNF-alpha (approximately 25%), IL-1beta (approximately 60%), and IL-6 (approximately 90%) when compared to the placebo group. Estradiol 25-42 interleukin 1 beta Rattus norvegicus 125-133 19520101-9 2009 In addition, DrosL treatment induced cytokines (TNF-alpha, IL-1beta and CINC-1) and NO release into the peritoneal cavity of rats. drosl 13-18 interleukin 1 beta Rattus norvegicus 59-67 20209965-4 2009 RESULT: Total alkaloids of Radix Aconiti Praeparata and total glycosides or polysaccharides of Radix Paeoniae Alba could relieve arthrocele and arthralgia and elevate the contents of L-ENK, beta-END, IL-2 and degrade the contents of SP, IgG, IL-1beta, IL-6 and inhibit abnormal secretion accentuation of synovial cell like fiber. Glycosides 62-72 interleukin 1 beta Rattus norvegicus 242-250 20209965-4 2009 RESULT: Total alkaloids of Radix Aconiti Praeparata and total glycosides or polysaccharides of Radix Paeoniae Alba could relieve arthrocele and arthralgia and elevate the contents of L-ENK, beta-END, IL-2 and degrade the contents of SP, IgG, IL-1beta, IL-6 and inhibit abnormal secretion accentuation of synovial cell like fiber. Polysaccharides 76-91 interleukin 1 beta Rattus norvegicus 242-250 20396745-3 2009 Intraperitoneal injection of interleukin-1beta (5 mug/kg, 10(8) U/mg) was accompanied by accumulation of Chinese ink in the mesenteric lymph nodes of unstressed passive and active rats. chinese ink 105-116 interleukin 1 beta Rattus norvegicus 29-46 18946717-9 2009 The secretion of IL-1beta and IFN-gamma was increased by about 50% when the PBMCs were cultured with the PGA scaffold. Polyglycolic Acid 105-108 interleukin 1 beta Rattus norvegicus 17-25 19592596-10 2009 Likewise, the inhibitory effects of IL-beta on beta-cell replication were not modified by glucose, and were only modestly prevented by IGF2 overexpression, in contrast with the higher protection against IL1B-induced apoptosis afforded by glucose and by IGF2 overexpression. Glucose 238-245 interleukin 1 beta Rattus norvegicus 203-207 19798548-8 2009 In many respects, celecoxib (5 mg/kg) was as potent as diclofenac in decreasing the elevated levels of IL-6, IL-1beta, TNF-alpha, LTB(4), PGE(2), but lacked any significant effect on TXB(2) level. Celecoxib 18-27 interleukin 1 beta Rattus norvegicus 109-117 19798548-8 2009 In many respects, celecoxib (5 mg/kg) was as potent as diclofenac in decreasing the elevated levels of IL-6, IL-1beta, TNF-alpha, LTB(4), PGE(2), but lacked any significant effect on TXB(2) level. Diclofenac 55-65 interleukin 1 beta Rattus norvegicus 109-117 19630503-10 2009 The concentration of IL-1beta was significantly higher in the non-resuscitated rats than in those receiving bicarbonate Ringer"s, lactated Ringer"s, or normal saline for early resuscitation. Bicarbonates 108-119 interleukin 1 beta Rattus norvegicus 21-29 19608326-10 2009 Dexmedetomidine-ketamine combination, but not dexmedetomidine or ketamine alone, also significantly inhibited haemorrhagic shock-induced upregulation of pulmonary inflammatory molecules, including nitric oxide, prostaglandin E(2), chemokine (e.g., macrophage inflammatory protein-2), and cytokines [e.g., interleukin (IL)-1beta, and IL-6]. Dexmedetomidine 0-15 interleukin 1 beta Rattus norvegicus 305-327 19608326-10 2009 Dexmedetomidine-ketamine combination, but not dexmedetomidine or ketamine alone, also significantly inhibited haemorrhagic shock-induced upregulation of pulmonary inflammatory molecules, including nitric oxide, prostaglandin E(2), chemokine (e.g., macrophage inflammatory protein-2), and cytokines [e.g., interleukin (IL)-1beta, and IL-6]. Ketamine 16-24 interleukin 1 beta Rattus norvegicus 305-327 19597040-5 2009 Resveratrol treatment (25 mg/kg per day, PO, from day 1 postmonocrotaline) attenuated right ventricular systolic pressure and pulmonary arterial remodeling, decreased expression of inflammatory cytokines (tumor necrosis factor-alpha, interleukin 1beta, interleukin 6, and platelet-derived growth factor-alpha/beta), and limited leukocyte infiltration in the lung. Resveratrol 0-11 interleukin 1 beta Rattus norvegicus 234-251 19582783-5 2009 AMPH, and EIH to a lesser extent, elicited a significant inflammatory response at 3 h as indicated by an increased MAV expression of cytokines Il1b, Il6, Ccl-2, Cxcl1, and Cxcl2. Amphetamine 0-4 interleukin 1 beta Rattus norvegicus 143-147 19347386-0 2009 Glutamine attenuates nitric oxide synthase expression and mitochondria membrane potential decrease in interleukin-1beta-activated rat hepatocytes. Glutamine 0-9 interleukin 1 beta Rattus norvegicus 102-119 19347386-12 2009 The Deltapsim of hepatocytes was markedly decreased after IL-1beta stimulation which was significantly attenuated by Gln at 5 and 10 mmol/l. Glutamine 117-120 interleukin 1 beta Rattus norvegicus 58-66 19347386-13 2009 NF-kappaB activity was increased by IL-1beta stimulation and this effect was augmented by Gln at 5 and 10 mol/l. Glutamine 90-93 interleukin 1 beta Rattus norvegicus 36-44 18976941-9 2009 Treatment with SR140333 substantially inhibited the increase in plasma extravasation and leukocyte influx at 4 and 24h, as well as the production of TNFalpha and IL-1beta into the joint cavity, but failed to affect changes in head-withdrawal threshold. SR 140333 15-23 interleukin 1 beta Rattus norvegicus 162-170 19556450-5 2009 In contrast, chronic treatment with a COX2-selective dose of rofecoxib exaggerated the harmful effects of the SFD, i.e., increasing vascular and renal dysfunction, dyslipidemia, hypertension, cardiac hypertrophy, PRA, aldosterone, and IL-1beta. rofecoxib 61-70 interleukin 1 beta Rattus norvegicus 235-243 19680075-7 2009 Thalidomide also caused a substantial reduction of 1) the rise in myeloperoxidase activity (mucosa); 2) the expression in the tissue of TNF-alpha, IL-1beta, transforming growth factor-beta, and vascular endothelial growth factor; 3) the increase in staining (immunohistochemistry) for nitrotyrosine and for poly(ADP ribose), as well as 4) the nuclear factor-kappaB activation caused by CG in the peritoneum. Thalidomide 0-11 interleukin 1 beta Rattus norvegicus 147-155 19627459-9 2009 Melatonin increased expression of novel transcription factor, Nrf2, and decreased expression of inflammatory mediators including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and inducible nitric oxide synthase. Melatonin 0-9 interleukin 1 beta Rattus norvegicus 158-180 19541419-6 2009 TNF-alpha and IL-1beta levels were also significantly increased in both serum and sciatic nerve of ethanol-treated rats. Ethanol 99-106 interleukin 1 beta Rattus norvegicus 14-22 19656406-7 2009 RESULTS: NNZ-2566 treatment significantly reduced injury-mediated up-regulation of IL-1beta, TNF-alpha, E-selectin and IL-6 mRNA during the acute injury phase. NNZ 2566 9-17 interleukin 1 beta Rattus norvegicus 83-91 20099767-0 2009 Six-shogaol inhibits production of tumour necrosis factor alpha, interleukin-1 beta and nitric oxide from lipopolysaccharide-stimulated RAW 264.7 macrophages. six-shogaol 0-11 interleukin 1 beta Rattus norvegicus 65-83 20099767-4 2009 METHODS: Effects of 6-shogaol were investigated on the production of the mediators TNF-alpha, IL-1-beta and NO (measured as nitrate)from macrophages. shogaol 20-29 interleukin 1 beta Rattus norvegicus 94-103 20099767-8 2009 Also, the inhibitory effects against TNF-alpha, IL-1beta and NO production from LPS activated macrophages are cellular mechanisms by which 6-shogaol produced its anti-inflammatory effects. shogaol 139-148 interleukin 1 beta Rattus norvegicus 48-56 19552966-3 2009 Somatostatin further enhanced the increase in PGE(2) release induced by IL-1beta, whereas cortistatin inhibited such increase. Prostaglandins E 46-49 interleukin 1 beta Rattus norvegicus 72-80 19375439-7 2009 In contrast, aspirin reduced both LPS- and IL-1beta induced fever, whereas diazepam had little effect on these fever states. Aspirin 13-20 interleukin 1 beta Rattus norvegicus 43-51 19656406-8 2009 ELISA cytokine array showed that NZ-2566 treatment significantly reduced levels of the pro-inflammatory cytokines IL-1beta, TNF-alpha and IFN-gamma in the injured brain, but did not affect anti-inflammatory cytokine IL-6 levels. nz-2566 33-40 interleukin 1 beta Rattus norvegicus 114-122 19299480-4 2009 In the present study, we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the ERK-dependent up-regulation of IL-1beta, TNF-alpha, and microsomal prostaglandin E synthase-1 (mPGES-1) in astrocytes and p38-dependent up-regulation of IL-6 in microglia in the rat spinal cord. Morphine 62-70 interleukin 1 beta Rattus norvegicus 145-153 19299480-6 2009 Interestingly, the inhibition of the ERK pathway suppressed the development of tolerance and morphine-induced up-regulation of IL-1beta, TNF-alpha, and mPGES-1. Morphine 93-101 interleukin 1 beta Rattus norvegicus 127-135 19557820-4 2009 They were screened by measuring prostaglandin E(2) (PGE(2)) production by CCD-18 colon fibroblast cells stimulated with IL-1beta. Dinoprostone 32-50 interleukin 1 beta Rattus norvegicus 120-128 19141058-9 2009 Stimulation with IL-1beta increased the level of PGE(2) in conditioned media of cultured FLS in a time-dependent manner up to 48 h. Immunohistochemistry showed a strong positive staining for COX-2 in the lining and sub-lining synovial tissues of the TMJ of IL-1beta-injected rats. Prostaglandins E 49-52 interleukin 1 beta Rattus norvegicus 17-25 19141058-11 2009 CONCLUSION: These data suggest that COX-2 expression stimulated by IL-1beta stimulates the production of PGE(2) in FLS and plays important roles in the progression of inflammation in TMJ. Prostaglandins E 105-108 interleukin 1 beta Rattus norvegicus 67-75 19076990-11 2009 CONCLUSION: This study shows that simvastatin therapy leads to a reversal of the cyclosporine A-induced bone loss, which may be mediated by downregulation of interleukin-1beta and prostaglandin E(2) production. Simvastatin 34-45 interleukin 1 beta Rattus norvegicus 158-175 19076990-11 2009 CONCLUSION: This study shows that simvastatin therapy leads to a reversal of the cyclosporine A-induced bone loss, which may be mediated by downregulation of interleukin-1beta and prostaglandin E(2) production. Cyclosporine 81-95 interleukin 1 beta Rattus norvegicus 158-175 19120693-6 2009 Dexamethasone (1-10 microM) reduced the LPS-evoked release of IL-1beta, TNF-alpha and L-selectin, decreased expression of CSE and iNOS and diminished nuclear factor kappaB (NF-kappaB)-DNA binding in isolated rat neutrophils. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 62-70 19557820-4 2009 They were screened by measuring prostaglandin E(2) (PGE(2)) production by CCD-18 colon fibroblast cells stimulated with IL-1beta. Dinoprostone 52-58 interleukin 1 beta Rattus norvegicus 120-128 19557820-8 2009 HCAF treatment diminished the expression of the cytokines IL-1beta, IL-8, and TNF-alpha, reduced malonyldialdehyde (MDA) levels and oxidative DNA damage (measured as 8-oxo-2"-deoxyguanosine levels) in distal colon mucosa. hcaf 0-4 interleukin 1 beta Rattus norvegicus 58-66 21155249-1 2009 AIM: To study the effects and mechanism of naloxone on the febrile response in IL-1beta-induced fever rats. Naloxone 43-51 interleukin 1 beta Rattus norvegicus 79-87 19535420-10 2009 Mucosal IL-1beta levels were lower in calcium-fed rats and histological colitis scores tended to be lower (P = 0.08). Calcium 38-45 interleukin 1 beta Rattus norvegicus 8-16 19671414-9 2009 The serum contents of IL-6 and IL-1beta were decreased in the astilbin group as compared with the untreated group (P<0.01). astilbin 62-70 interleukin 1 beta Rattus norvegicus 31-39 19671414-10 2009 CONCLUSION: Astilbin can ameliorate kidney IR injury in rats by inhibiting the production of chemokine MCP-1 and cytokines IL-6 and IL-1beta. astilbin 12-20 interleukin 1 beta Rattus norvegicus 132-140 19671767-5 2009 Celastrol, BMS-345541, and parthenolide abolished IL1beta and tumor necrosis factor alpha-induced IkappaB phosphorylation and prevented nuclear translocation of NF-kappaB and DNA binding. celastrol 0-9 interleukin 1 beta Rattus norvegicus 50-57 19671767-5 2009 Celastrol, BMS-345541, and parthenolide abolished IL1beta and tumor necrosis factor alpha-induced IkappaB phosphorylation and prevented nuclear translocation of NF-kappaB and DNA binding. parthenolide 27-39 interleukin 1 beta Rattus norvegicus 50-57 21155249-5 2009 RESULTS: Naloxone alleviated IL-1beta-induced fever and the contents of cAMP in hypothalamus and AVP in VSA were correspondingly decreased (P < 0.01). Naloxone 9-17 interleukin 1 beta Rattus norvegicus 29-37 25903672-6 2009 Wounds treated with the combination of SS and SSD cream showed higher levels of IL-1beta and TNF-alpha when compared to wounds treated by SS alone, but the differences were not significant. H-SER-SER-OH 39-41 interleukin 1 beta Rattus norvegicus 80-88 25903672-6 2009 Wounds treated with the combination of SS and SSD cream showed higher levels of IL-1beta and TNF-alpha when compared to wounds treated by SS alone, but the differences were not significant. H-SER-SER-OH 46-48 interleukin 1 beta Rattus norvegicus 80-88 21155249-6 2009 CONCLUSION: Naloxone could inhibit IL-1beta-induced fever in rats, and the mechanism might be due to inhibiting synthesis of cAMP in hypothalamus and promoting release of AVP in VSA. Naloxone 12-20 interleukin 1 beta Rattus norvegicus 35-43 21155249-6 2009 CONCLUSION: Naloxone could inhibit IL-1beta-induced fever in rats, and the mechanism might be due to inhibiting synthesis of cAMP in hypothalamus and promoting release of AVP in VSA. Cyclic AMP 125-129 interleukin 1 beta Rattus norvegicus 35-43 19401198-6 2009 Furthermore, CTS inhibited NF-kappaB translocation, expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), neutrophil infiltration and MPO activity in ischemic myocardial tissues. cryptotanshinone 13-16 interleukin 1 beta Rattus norvegicus 105-113 19951488-0 2009 [Effects of edaravone on the expression of interleukin-1beta, nuclear factor-kappaB and neuron apoptosis in juvenile rat hippocampus after status convulsion]. Edaravone 12-21 interleukin 1 beta Rattus norvegicus 43-60 19951488-1 2009 OBJECTIVE: To investigate the effect of edaravone on expression of interleukin-1beta (IL-1beta), nuclear factor-kappaB (NF-kappaB) and neuron apoptosis in the juvenile rat hippocampus after status convulsion (SC). Edaravone 40-49 interleukin 1 beta Rattus norvegicus 67-84 19951488-1 2009 OBJECTIVE: To investigate the effect of edaravone on expression of interleukin-1beta (IL-1beta), nuclear factor-kappaB (NF-kappaB) and neuron apoptosis in the juvenile rat hippocampus after status convulsion (SC). Edaravone 40-49 interleukin 1 beta Rattus norvegicus 86-94 19951488-15 2009 CONCLUSIONS: Edaravone inhibited expression of IL-1beta and NF-kappaB in pilocarpine-induced seizures in rat hippocampus, reduced the number of neuronal apoptosis. Edaravone 13-22 interleukin 1 beta Rattus norvegicus 47-55 19951488-15 2009 CONCLUSIONS: Edaravone inhibited expression of IL-1beta and NF-kappaB in pilocarpine-induced seizures in rat hippocampus, reduced the number of neuronal apoptosis. Pilocarpine 73-84 interleukin 1 beta Rattus norvegicus 47-55 19359664-7 2009 Nuclear factor kappa-B (NF-kappaB) was activated in IL-1beta-stimulated RASMCs, and treatment with NF-kappaB decoy oligodeoxynucleotides (ODN) restored reduced expression of procollagen type I, III, and LOX in vitro. rasmcs 72-78 interleukin 1 beta Rattus norvegicus 52-60 19138443-0 2009 The alpha-glucosidase inhibitor miglitol suppresses postprandial hyperglycaemia and interleukin-1beta and tumour necrosis factor-alpha gene expression in rat peripheral leucocytes induced by intermittent sucrose loading. Sucrose 204-211 interleukin 1 beta Rattus norvegicus 84-134 19138443-7 2009 Gene expression levels of IL-1beta and TNF-alpha were higher in the streptozotocin-treated rats at fasting on day 1 than in saline-treated rats. Streptozocin 68-82 interleukin 1 beta Rattus norvegicus 26-34 19138443-8 2009 Fasting IL-1beta and TNF-alpha gene expression on day 1 were not only increased at 3 h on the same day of sucrose loading, but was also increased at the fasting period on day 4. Sucrose 106-113 interleukin 1 beta Rattus norvegicus 8-16 19138443-10 2009 The present results suggest that miglitol decreases postprandial hyperglycaemia and intermittent sucrose-induced expression of the IL-1beta and TNF-alpha genes in rat peripheral leucocytes. Sucrose 97-104 interleukin 1 beta Rattus norvegicus 131-139 19375498-4 2009 GYY4137 (50 mg/kg, ip) administered to conscious rats 1 or 2 h after (but not 1 h before) LPS decreased the subsequent (4 h) rise in plasma proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6), nitrite/nitrate, C-reactive protein, and L-selectin. GYY 4137 0-7 interleukin 1 beta Rattus norvegicus 178-186 20095326-4 2009 RESULTS: The level of IL-1 beta increased significantly on the 1st, the 3rd, the 7th day in PQ group compared with control group (P<0.01). Primaquine 92-94 interleukin 1 beta Rattus norvegicus 22-31 20095326-7 2009 Meanwhile, IL-1 beta and TNF-alpha were positively correlated with lung coefficient (r=0.37, 0.46, P<0.05 or P<0.01 ); TGF-beta1 and PDGF had positive correlation with hydroxyproline (r=0.56, 0.89, P<0.01). Hydroxyproline 174-188 interleukin 1 beta Rattus norvegicus 11-20 20095326-9 2009 There was a significant decrease of IL-1 beta, TGF-beta1, TNF-alpha and PDGF in PQ + PDTC group compared with PQ group (P<0.05 or P<0.01) in the corresponding sacrifice dates. Primaquine 80-82 interleukin 1 beta Rattus norvegicus 36-45 19398497-1 2009 Cytokines such as interleukin-1beta (IL-1beta) stimulate inducible nitric oxide synthase (iNOS) expression and nitric oxide overproduction leading to beta-cell damage. Nitric Oxide 67-79 interleukin 1 beta Rattus norvegicus 18-35 19398497-1 2009 Cytokines such as interleukin-1beta (IL-1beta) stimulate inducible nitric oxide synthase (iNOS) expression and nitric oxide overproduction leading to beta-cell damage. Nitric Oxide 67-79 interleukin 1 beta Rattus norvegicus 37-45 19398497-5 2009 EX-4 inhibited IL-1beta-induced iNOS protein expression and nitrite production. Nitrites 60-67 interleukin 1 beta Rattus norvegicus 15-23 19235895-8 2009 The augmenting effects of IL-1beta on the BK-induced neural [Ca(2+)](i) increase and PGE(2) release from enteric glial cells were abolished by a phospholipase A(2) (PLA(2)) inhibitor and a COX inhibitor, and partly suppressed by a COX-2 inhibitor. Dinoprostone 85-91 interleukin 1 beta Rattus norvegicus 26-34 19398497-11 2009 Meanwhile, forskolin significantly inhibited IL-1beta-induced iNOS protein, which was reversed by H-89, a protein kinase A (PKA) inhibitor. Colforsin 11-20 interleukin 1 beta Rattus norvegicus 45-53 19398497-11 2009 Meanwhile, forskolin significantly inhibited IL-1beta-induced iNOS protein, which was reversed by H-89, a protein kinase A (PKA) inhibitor. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 98-102 interleukin 1 beta Rattus norvegicus 45-53 19398497-12 2009 Moreover, EX-4 pretreatment restored IL-1beta-induced decrease in cAMP toward control level. Cyclic AMP 66-70 interleukin 1 beta Rattus norvegicus 37-45 19398497-14 2009 We therefore concluded that EX-4 inhibited IL-1beta-induced iNOS protein and nitrite production via cAMP/PKA system irrespective of both transcriptional and posttranscriptional mechanisms of iNOS gene, and this inhibitory effect of EX-4 appears to be regulated at posttranslational level. Nitrites 77-84 interleukin 1 beta Rattus norvegicus 43-51 19398497-14 2009 We therefore concluded that EX-4 inhibited IL-1beta-induced iNOS protein and nitrite production via cAMP/PKA system irrespective of both transcriptional and posttranscriptional mechanisms of iNOS gene, and this inhibitory effect of EX-4 appears to be regulated at posttranslational level. Cyclic AMP 100-104 interleukin 1 beta Rattus norvegicus 43-51 19235895-10 2009 LPS promotes IL-1beta secretion from enteric glial cells, resulting in augmentation of the neural response to BK through PGE(2) release via glial PLA(2) and COX-2. Prostaglandins E 121-124 interleukin 1 beta Rattus norvegicus 13-21 19362079-8 2009 The IL-1beta-stimulated levels of GDNF were suppressed by wedelolactone, an inhibitor of IkappaB kinase, SB203580, an inhibitor of p38 MAP kinase, PD98059, an inhibitor of MAP kinase kinase 1/2 or Janus family of tyrosine kinase (JAK) inhibitor I, an inhibitor of upstream kinase of STAT3. wedelolactone 58-71 interleukin 1 beta Rattus norvegicus 4-12 19041098-6 2009 Experiment II: Male and female RASMCs were incubated for 48 h in Dulbecco"s modified Eagler"s medium containing IL-1beta and 17-beta-estradiol at doses from 1x10(-10) to 1x10(-6) molar. dulbecco"s modified eagler"s medium 65-100 interleukin 1 beta Rattus norvegicus 112-120 19041098-9 2009 Aortas from males, females, and estradiol-treated males were stimulated with IL-1beta for 48-h, and MMP2 activity in the conditioned media was determined. Estradiol 32-41 interleukin 1 beta Rattus norvegicus 77-85 19041098-10 2009 RESULTS: Experiment I: MMP2 gene expression was 3-fold higher in male compared with female IL-1beta stimulated RASMCs (P<0.0001). rasmcs 111-117 interleukin 1 beta Rattus norvegicus 91-99 19620074-9 2009 The expressions of TNF-alpha and IL-1beta were significantly higher in MTX-treated group than in the control group. Methotrexate 71-74 interleukin 1 beta Rattus norvegicus 33-41 19620074-10 2009 The expression of TNF-alpha and IL-1beta mRNA in the Changyanqing group and NAC group were significantly lower, but IL-10 significantly higher than those of the MTX group. Methotrexate 161-164 interleukin 1 beta Rattus norvegicus 32-40 19615317-1 2009 OBJECTIVE: To investigate the effects of genistein (Gen) on interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) secreted by fibroblast-like synoviocytes (FLSs) of rats with type II collagen-induced arthritis (CIA). Genistein 41-50 interleukin 1 beta Rattus norvegicus 60-77 19615317-9 2009 After administration of different concentrations of Gen (100, 200, 400 micromol/L), the contents of IL-1beta and TNF-alpha in supernatants of FLSs were decreased dose-dependently. Genistein 52-55 interleukin 1 beta Rattus norvegicus 100-108 19615317-10 2009 CONCLUSION: Genistein can suppress the secretion of TNF-alpha and IL-1beta in FLSs dose-dependently, which may be one of the mechanisms for genistein in inhibiting the arthromeningitis of CIA rats. Genistein 12-21 interleukin 1 beta Rattus norvegicus 66-74 19615317-10 2009 CONCLUSION: Genistein can suppress the secretion of TNF-alpha and IL-1beta in FLSs dose-dependently, which may be one of the mechanisms for genistein in inhibiting the arthromeningitis of CIA rats. Genistein 140-149 interleukin 1 beta Rattus norvegicus 66-74 19574840-0 2009 Simvastatin attenuates microglial cells and astrocyte activation and decreases interleukin-1beta level after traumatic brain injury. Simvastatin 0-11 interleukin 1 beta Rattus norvegicus 79-96 19574840-9 2009 Simvastatin only reduced the level of IL-1beta but not IL-6 and tumor necrosis factor-alpha, compared with the saline group. Simvastatin 0-11 interleukin 1 beta Rattus norvegicus 38-46 19574840-13 2009 Simvastatin selectively reduces IL-1beta expression and inhibits the activation of microglial cells and astrocytes after TBI, which might be one of the mechanisms underlying the therapeutic benefits of simvastatin treatment of TBI. Simvastatin 0-11 interleukin 1 beta Rattus norvegicus 32-40 19574840-13 2009 Simvastatin selectively reduces IL-1beta expression and inhibits the activation of microglial cells and astrocytes after TBI, which might be one of the mechanisms underlying the therapeutic benefits of simvastatin treatment of TBI. Simvastatin 202-213 interleukin 1 beta Rattus norvegicus 32-40 19358839-9 2009 Liver tissue from high-fat and MC- rats stained positive for IL-1beta, a pro-inflammatory cytokine known to decrease expression of NTCP, OATP and OAT transporters, suggesting a plausible mechanism for the observed transporter alterations. Methylcholanthrene 31-33 interleukin 1 beta Rattus norvegicus 61-69 19358839-9 2009 Liver tissue from high-fat and MC- rats stained positive for IL-1beta, a pro-inflammatory cytokine known to decrease expression of NTCP, OATP and OAT transporters, suggesting a plausible mechanism for the observed transporter alterations. periodate-oxidized adenosine 5'-triphosphate 137-141 interleukin 1 beta Rattus norvegicus 61-69 19362079-8 2009 The IL-1beta-stimulated levels of GDNF were suppressed by wedelolactone, an inhibitor of IkappaB kinase, SB203580, an inhibitor of p38 MAP kinase, PD98059, an inhibitor of MAP kinase kinase 1/2 or Janus family of tyrosine kinase (JAK) inhibitor I, an inhibitor of upstream kinase of STAT3. SB 203580 105-113 interleukin 1 beta Rattus norvegicus 4-12 19362079-8 2009 The IL-1beta-stimulated levels of GDNF were suppressed by wedelolactone, an inhibitor of IkappaB kinase, SB203580, an inhibitor of p38 MAP kinase, PD98059, an inhibitor of MAP kinase kinase 1/2 or Janus family of tyrosine kinase (JAK) inhibitor I, an inhibitor of upstream kinase of STAT3. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 147-154 interleukin 1 beta Rattus norvegicus 4-12 19715517-11 2009 Significantly greater up-regulation of CXC motif chemokine ligand and interleukin-1beta occurred in the livers of rats that received norepinephrine and vasopressin than in those that received no resuscitation. Norepinephrine 133-147 interleukin 1 beta Rattus norvegicus 70-87 19344884-7 2009 NAC before LPS significantly reduced the fetal IL-6 and IL-1 beta response. Acetylcysteine 0-3 interleukin 1 beta Rattus norvegicus 56-65 18973186-0 2009 Ursolic acid inhibits IL-1beta or TNF-alpha-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-zeta and downregulating the MMP-9 expression. ursolic acid 0-12 interleukin 1 beta Rattus norvegicus 22-30 19046481-9 2009 In contrast, in vitro exposure of cultured glial cells to noradrenaline suppressed IL-1beta, TNF-alpha, iNOS and CD40 expression. Norepinephrine 58-71 interleukin 1 beta Rattus norvegicus 83-91 19457130-5 2009 The results showed that tamoxifen, administered at 30 min post-injury, significantly decreased interleukin-1beta (IL-1beta) production induced by microglial activation, alleviated the amount of Evans blue leakage and edema formation. Tamoxifen 24-33 interleukin 1 beta Rattus norvegicus 95-112 19457130-5 2009 The results showed that tamoxifen, administered at 30 min post-injury, significantly decreased interleukin-1beta (IL-1beta) production induced by microglial activation, alleviated the amount of Evans blue leakage and edema formation. Tamoxifen 24-33 interleukin 1 beta Rattus norvegicus 114-122 17950491-4 2009 In this study the PPAR gamma agonist, rosiglitazone, was orally administered to young and aged rats, and we report that the age-related increases in NO and IL-1 beta production were attenuated in hippocampus of rosiglitazone-treated aged rats and that this was associated with a restoration of LTP. Rosiglitazone 38-51 interleukin 1 beta Rattus norvegicus 156-165 17950491-4 2009 In this study the PPAR gamma agonist, rosiglitazone, was orally administered to young and aged rats, and we report that the age-related increases in NO and IL-1 beta production were attenuated in hippocampus of rosiglitazone-treated aged rats and that this was associated with a restoration of LTP. Rosiglitazone 211-224 interleukin 1 beta Rattus norvegicus 156-165 19216056-5 2009 RESULTS: Microarray analysis revealed that gene expression of interleukin-1beta and putative inflammatory cytokines, S100a4/6/8/9, was induced by streptozotocin treatment. Streptozocin 146-160 interleukin 1 beta Rattus norvegicus 62-79 19138753-6 2009 Immunohistochemical, immunofluorescent and immunoblot studies revealed that EGCG supplementation decreased the levels of nuclear factor-kappaB (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), which were increased upon bleomycin induction. epigallocatechin gallate 76-80 interleukin 1 beta Rattus norvegicus 200-218 19138753-6 2009 Immunohistochemical, immunofluorescent and immunoblot studies revealed that EGCG supplementation decreased the levels of nuclear factor-kappaB (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), which were increased upon bleomycin induction. epigallocatechin gallate 76-80 interleukin 1 beta Rattus norvegicus 220-229 18973186-2 2009 In the present study, we found that UA was able to reduce interleukin-1 beta (IL-1beta) or tumor necrosis-alpha (TNF-alpha)-induced rat C6 glioma cell invasion, which was examined by a reconstituted basement membrane in a set of transwell chambers. ursolic acid 36-38 interleukin 1 beta Rattus norvegicus 58-76 18973186-2 2009 In the present study, we found that UA was able to reduce interleukin-1 beta (IL-1beta) or tumor necrosis-alpha (TNF-alpha)-induced rat C6 glioma cell invasion, which was examined by a reconstituted basement membrane in a set of transwell chambers. ursolic acid 36-38 interleukin 1 beta Rattus norvegicus 78-86 19463182-8 2009 The cooperative effect of Sn was mimicked with the combination of interleukin-1beta, interleukin-2, interleukin-6, interleukin-17, interferon-gamma and tumor necrosis factor-alpha. Tin 26-28 interleukin 1 beta Rattus norvegicus 66-83 19079834-7 2009 The HFO diet was more effective in lowering IL-1beta and increasing IL-10 production (ConA, P < 0.05). 1,3,3,3-tetrafluoropropene 4-7 interleukin 1 beta Rattus norvegicus 44-52 19401694-8 2009 Cipro normalised the hyper-responsiveness of MLN cells, and in the spleen, it partially restored the proliferative response and normalised depressed production of IL-1beta and IL-6. Ciprofloxacin 0-5 interleukin 1 beta Rattus norvegicus 163-171 19225144-4 2009 Candesartan pretreatment reduced the LPS-induced release of TNF-alpha, IL-1beta, and IL-6 into the circulation. candesartan 0-11 interleukin 1 beta Rattus norvegicus 71-79 19458216-4 2009 In late pregnancy, HPA axis responses to stressors, including IL-1beta, are attenuated by a central opioid mechanism that auto-inhibits noradrenaline release in the PVN. Norepinephrine 136-149 interleukin 1 beta Rattus norvegicus 62-70 19458216-5 2009 Here we show that the neuroactive progesterone metabolite allopregnanolone induces these changes in HPA responsiveness to IL-1beta in pregnancy. Pregnanolone 58-74 interleukin 1 beta Rattus norvegicus 122-130 19458216-6 2009 In late pregnancy, inhibition of 5alpha-reductase (an allopregnanolone-synthesizing enzyme) with finasteride restored HPA axis responses (rapidly increased pPVN CRH mRNA expression, ACTH, and corticosterone secretion) to IL-1beta. Finasteride 97-108 interleukin 1 beta Rattus norvegicus 221-229 19458216-9 2009 Naloxone, an opioid antagonist, restores HPA axis responses to IL-1beta in pregnancy but had no additional effect after finasteride, indicating a causal connection between allopregnanolone and the endogenous opioid mechanism. Naloxone 0-8 interleukin 1 beta Rattus norvegicus 63-71 19458216-10 2009 Indeed, allopregnanolone induced opioid inhibition over HPA responses to IL-1beta in virgin rats. Pregnanolone 8-24 interleukin 1 beta Rattus norvegicus 73-81 19079834-8 2009 This lower IL-1beta production was accompanied by a lower proportion of major histocompatability complex class II-positive cells and a higher incorporation of DHA into lipid rafts. dehydroacetic acid 159-162 interleukin 1 beta Rattus norvegicus 11-19 19233196-8 2009 Suppression of mRNA expression for IL-1alpha, IL-1beta, IL-4, IL-6, and TNF-alpha was noted in the heart tissue treated with 4-1BBIg. 4-1bbig 125-132 interleukin 1 beta Rattus norvegicus 46-54 19281808-3 2009 Chronic gastric ulcer induced in rats by intraluminal application of acetic acid resulted in elevation of proinflammatory cytokines gene expression, such as, TNF-alpha (Tumor Necrosis Factor-alpha), IL-1beta (Interleukin-1beta) and the protein levels of nuclear p65 subunit of NF-kappaB (Nuclear Factor-kappaB) but decreased levels of PPAR-gamma gene expression. Acetic Acid 69-80 interleukin 1 beta Rattus norvegicus 199-207 19281808-3 2009 Chronic gastric ulcer induced in rats by intraluminal application of acetic acid resulted in elevation of proinflammatory cytokines gene expression, such as, TNF-alpha (Tumor Necrosis Factor-alpha), IL-1beta (Interleukin-1beta) and the protein levels of nuclear p65 subunit of NF-kappaB (Nuclear Factor-kappaB) but decreased levels of PPAR-gamma gene expression. Acetic Acid 69-80 interleukin 1 beta Rattus norvegicus 209-226 19281808-4 2009 Pioglitazone treatment reduced the severity of ulceration, repressed levels of TNF-alpha, IL-1beta and nuclear p65 subunit as well as increased the abundance of PPAR-gamma in gastric mucosa. Pioglitazone 0-12 interleukin 1 beta Rattus norvegicus 90-98 19281808-7 2009 Moreover, pharmacological inhibition of glucocorticoid receptor function by its antagonist (RU486) inhibited pioglitazone mediated downregulation of TNF-alpha and IL-1beta gene expression confirming involvement of glucocorticoid receptor in pioglitazone mediated ulcer healing. Mifepristone 92-97 interleukin 1 beta Rattus norvegicus 163-171 19281808-7 2009 Moreover, pharmacological inhibition of glucocorticoid receptor function by its antagonist (RU486) inhibited pioglitazone mediated downregulation of TNF-alpha and IL-1beta gene expression confirming involvement of glucocorticoid receptor in pioglitazone mediated ulcer healing. Pioglitazone 109-121 interleukin 1 beta Rattus norvegicus 163-171 19273740-6 2009 Compared with vehicle, the subhypotensive dose of moxonidine resulted in lower (P<0.01) heart rate, left ventricular hypertrophy, cardiomyocyte cross-sectional area, interleukin 1 beta, tumor necrosis factor-alpha, and mRNA for natriuretic peptides. moxonidine 50-60 interleukin 1 beta Rattus norvegicus 169-216 19115234-8 2009 Moreover, the GSH-based cellular response was achieved together with a brain-derived neurotrophic factor over-expression as well as with the interleukin 1beta-dependent regulation of pro-survival signaling pathways after ELF-MF exposure. Glutathione 14-17 interleukin 1 beta Rattus norvegicus 141-158 19220658-8 2009 Trinitrobenzene sulfonic acid-induced expression of TNF-alpha and IL-1beta was reduced by muscovite and 5-ASA treatment. Trinitrobenzenesulfonic Acid 0-29 interleukin 1 beta Rattus norvegicus 66-74 19220658-8 2009 Trinitrobenzene sulfonic acid-induced expression of TNF-alpha and IL-1beta was reduced by muscovite and 5-ASA treatment. muscovite 90-99 interleukin 1 beta Rattus norvegicus 66-74 19220658-8 2009 Trinitrobenzene sulfonic acid-induced expression of TNF-alpha and IL-1beta was reduced by muscovite and 5-ASA treatment. Mesalamine 104-109 interleukin 1 beta Rattus norvegicus 66-74 19040799-5 2009 RESULTS: Microinjection of IL-1beta (0.1 or 0.2 ng) resulted in increases in blood pressure in a dose-dependent manner, and the pressor effect caused by administration of IL-1beta (0.2 ng) could be attenuated by pre-treatment with AT(1) receptor antagonist (100 ng Losartan). Losartan 265-273 interleukin 1 beta Rattus norvegicus 27-35 19416632-11 2009 Moreover, the expression of several genes involved in inflammation and pain, as IL-1beta, TNFalpha, COX2 and iNOS, was up-regulated in colonic tissue from post-colitis rats and NO2-Arg-Trim, but not trimebutine, effectively reversed this effect. Nitroarginine 177-184 interleukin 1 beta Rattus norvegicus 80-88 19416632-11 2009 Moreover, the expression of several genes involved in inflammation and pain, as IL-1beta, TNFalpha, COX2 and iNOS, was up-regulated in colonic tissue from post-colitis rats and NO2-Arg-Trim, but not trimebutine, effectively reversed this effect. Trimebutine 199-210 interleukin 1 beta Rattus norvegicus 80-88 19303104-2 2009 Evidence suggests that tumor necrosis factor-alpha (R&D Systems), interleukin-1beta and cyclooxygenase-2 are directly involved in the pathogenesis of cyclophosphamide induced cystitis and these molecules depend on transcription factor NF-kappaB for maximal secretion. Cyclophosphamide 154-170 interleukin 1 beta Rattus norvegicus 70-87 19040799-5 2009 RESULTS: Microinjection of IL-1beta (0.1 or 0.2 ng) resulted in increases in blood pressure in a dose-dependent manner, and the pressor effect caused by administration of IL-1beta (0.2 ng) could be attenuated by pre-treatment with AT(1) receptor antagonist (100 ng Losartan). Losartan 265-273 interleukin 1 beta Rattus norvegicus 171-179 19249288-7 2009 RESULTS: Hydrogen-rich saline treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, NF-kappaB activation and the pro-inflammatory cytokine interleukin IL-1beta and TNF-alpha in the lung tissues compared with those in saline-treated rat. Hydrogen 9-17 interleukin 1 beta Rattus norvegicus 179-187 19249288-7 2009 RESULTS: Hydrogen-rich saline treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, NF-kappaB activation and the pro-inflammatory cytokine interleukin IL-1beta and TNF-alpha in the lung tissues compared with those in saline-treated rat. Sodium Chloride 23-29 interleukin 1 beta Rattus norvegicus 179-187 19493399-16 2009 Similarly, pulmonary IL-1beta levels were elevated markedly in the saline + lipopolysaccharide group in contrast to the saline group, whereas the elevation was much less in the erythropoietin + lipopolysaccharide group. Sodium Chloride 67-73 interleukin 1 beta Rattus norvegicus 21-29 19368815-2 2009 Compared to the control group, combination therapy group with melatonin (10 mg/kg) and DEX (0.025 mg/kg) significantly reduced the degree of (1) brain edema, (2) the permeability of blood brain barrier (measured by Evans blue), (3) Oxidative stress (evaluated by malondialdehyde assay), (4) cytokines expression (tumor necrosis factor-alpha and interleukin-1beta), and (5) apoptosis (measured by Bax and Bcl-2 expression). Melatonin 62-71 interleukin 1 beta Rattus norvegicus 345-362 19493399-16 2009 Similarly, pulmonary IL-1beta levels were elevated markedly in the saline + lipopolysaccharide group in contrast to the saline group, whereas the elevation was much less in the erythropoietin + lipopolysaccharide group. Sodium Chloride 120-126 interleukin 1 beta Rattus norvegicus 21-29 19368815-2 2009 Compared to the control group, combination therapy group with melatonin (10 mg/kg) and DEX (0.025 mg/kg) significantly reduced the degree of (1) brain edema, (2) the permeability of blood brain barrier (measured by Evans blue), (3) Oxidative stress (evaluated by malondialdehyde assay), (4) cytokines expression (tumor necrosis factor-alpha and interleukin-1beta), and (5) apoptosis (measured by Bax and Bcl-2 expression). Dexamethasone 87-90 interleukin 1 beta Rattus norvegicus 345-362 19109696-6 2009 Furthermore, reduced activation of JNK, utilizing JNK inhibitor SP600125, resulted in significant protection from IL-1beta- or thapsigargin-induced apoptosis via ER stress. pyrazolanthrone 64-72 interleukin 1 beta Rattus norvegicus 114-122 19171675-1 2009 Whereas many cytochrome P450 enzymes are transcriptionally suppressed by inflammatory stimuli, down-regulation of CYP2B protein by the inflammatory cytokine interleukin (IL)-1beta is nitric oxide (NO)-dependent and occurs via polyubiquitination and proteasomal degradation. Nitric Oxide 183-195 interleukin 1 beta Rattus norvegicus 157-179 19171675-4 2009 In cultured rat hepatocytes treated with phenobarbital, IL-1beta stimulation failed to down-regulate CYP3A1 mRNA within 24 h of treatment, whereas CYP3A protein was down-regulated to 40% of control within 6 h, showing the post-transcriptional down-regulation of CYP3A1 protein. Phenobarbital 41-54 interleukin 1 beta Rattus norvegicus 56-64 19166837-7 2009 As a result, we found that treatment with simvastatin markedly inhibited the mRNA and protein expressions of TLR4, NF-kappaB and the downstream inflammatory agents, such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and intercellular adhesion molecule-1 (ICAM-1). Simvastatin 42-53 interleukin 1 beta Rattus norvegicus 173-190 19166837-7 2009 As a result, we found that treatment with simvastatin markedly inhibited the mRNA and protein expressions of TLR4, NF-kappaB and the downstream inflammatory agents, such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and intercellular adhesion molecule-1 (ICAM-1). Simvastatin 42-53 interleukin 1 beta Rattus norvegicus 192-200 19288032-9 2009 Furthermore, a protective effect of FXE was demonstrated by reduction in NO generation and iNOS expression, as well as the normal insulin secreting responses to glucose observed in IL-1beta and IFN-gamma-treated islets. Glucose 161-168 interleukin 1 beta Rattus norvegicus 181-189 19060282-0 2009 Differential regulation of high glucose-induced glyceraldehyde-3-phosphate dehydrogenase nuclear accumulation in Muller cells by IL-1beta and IL-6. Glucose 32-39 interleukin 1 beta Rattus norvegicus 129-137 19060282-1 2009 PURPOSE: This study determined the role of the proinflammatory cytokines known to be elevated in the diabetic retina, namely IL-1beta, TNFalpha, and IL-6, in a high glucose-induced nuclear accumulation of GAPDH in retinal Muller cells, an event considered crucial for the induction of cell death. Glucose 165-172 interleukin 1 beta Rattus norvegicus 125-133 19060282-3 2009 RESULTS: High glucose induced IL-1beta, weak IL-6, and no TNFalpha production by rMC-1 and HMCs. Glucose 14-21 interleukin 1 beta Rattus norvegicus 30-38 19060282-5 2009 Further, high glucose-induced GAPDH nuclear accumulation in Muller cells was mediated by IL-1beta. Glucose 14-21 interleukin 1 beta Rattus norvegicus 89-97 19060282-6 2009 Inhibition of the IL-1 receptor using an IL-1 receptor antagonist (IL-1ra; 50 ng/mL) or inhibition of IL-1beta production using a specific caspase-1 inhibitor (YVAD-fmk; 100 microM) significantly decreased high glucose-induced GAPDH nuclear accumulation. tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone 160-168 interleukin 1 beta Rattus norvegicus 102-110 19060282-6 2009 Inhibition of the IL-1 receptor using an IL-1 receptor antagonist (IL-1ra; 50 ng/mL) or inhibition of IL-1beta production using a specific caspase-1 inhibitor (YVAD-fmk; 100 microM) significantly decreased high glucose-induced GAPDH nuclear accumulation. Glucose 211-218 interleukin 1 beta Rattus norvegicus 102-110 19060282-9 2009 CONCLUSIONS: These results revealed a novel mechanism for high glucose-induced GAPDH nuclear accumulation in Muller cells through production and autocrine stimulation by IL-1beta. Glucose 63-70 interleukin 1 beta Rattus norvegicus 170-178 19060282-10 2009 The protective role of IL-6 in high glucose- and IL-1beta-induced toxicity indicates that changes in the balance of these cytokines might contribute to cellular damage mediated by elevated glucose levels. Glucose 189-196 interleukin 1 beta Rattus norvegicus 49-57 19220703-6 2009 Minocycline treatment prevented both microglial activation as well as the up-regulation of IL-1beta, IotaL-6 and TNF-alpha mRNA and protein expression with a concomitant attenuation of the progression of encephalopathy and brain edema. Minocycline 0-11 interleukin 1 beta Rattus norvegicus 91-99 18389381-7 2009 NAC inhibits the pro-inflammatory factors expressions (TNF-alphaand IL-1beta) stimulated by ISO. Acetylcysteine 0-3 interleukin 1 beta Rattus norvegicus 68-76 19217659-3 2009 Third ventricle injections of IL-1beta significantly inhibited the increase in water intake observed in those situations. Water 79-84 interleukin 1 beta Rattus norvegicus 30-38 19138703-6 2009 RESULTS: After 10 weeks of streptozotocin injection, the rats produced significant increase in transfer latency which was coupled with enhanced acetylcholinesterase activity, increased oxidative-nitrosative stress, TNF-alpha, IL-1beta, caspase-3 activity and active p65 subunit of NFkappabeta in different regions of diabetic rat brain. Streptozocin 27-41 interleukin 1 beta Rattus norvegicus 226-234 19645241-5 2009 Tumor necrosis factor-alpha (TNF-alpha) activity was measured by L929 cytotoxicity bioassay and Interleukin (IL)-1beta activity was measured by MTT dye reduction. monooxyethylene trimethylolpropane tristearate 144-147 interleukin 1 beta Rattus norvegicus 96-118 19022353-4 2009 The present study was designed to evaluate the effects of EA and antisense oligodeoxynucleotide (ODN) to IL-1 receptor type I (IL-1RI) on carrageenan-induced thermal hyperalgesia and the expression of IL-1beta as well as IL-1RI. Oligodeoxyribonucleotides 97-100 interleukin 1 beta Rattus norvegicus 201-209 19217659-4 2009 The pharmacological blockade of central KOR by the selective KOR antagonist nor-binaltorphimine (BNI) at different doses significantly inhibited the antidipsogenic effect induced by the central administration of IL-1beta in all conditions tested: dehydration, hypovolemia and hyperosmolarity. norbinaltorphimine 76-95 interleukin 1 beta Rattus norvegicus 212-220 19217659-4 2009 The pharmacological blockade of central KOR by the selective KOR antagonist nor-binaltorphimine (BNI) at different doses significantly inhibited the antidipsogenic effect induced by the central administration of IL-1beta in all conditions tested: dehydration, hypovolemia and hyperosmolarity. norbinaltorphimine 97-100 interleukin 1 beta Rattus norvegicus 212-220 19217659-7 2009 Furthermore, the inhibitory effects of IL-1beta on water intake cannot be attributed to sickness-like effects induced by these compounds, since an aversion test excluded this possibility. Water 51-56 interleukin 1 beta Rattus norvegicus 39-47 19595066-0 2009 [Glutamine inhibits interleukin-1beta induced nitric oxide production and inducible nitric oxide synthase expression: experiment with cultured rat hepatocytes]. Glutamine 1-10 interleukin 1 beta Rattus norvegicus 20-37 19171179-0 2009 In inflammatory reactive astrocytes co-cultured with brain endothelial cells nicotine-evoked Ca(2+) transients are attenuated due to interleukin-1beta release and rearrangement of actin filaments. Nicotine 77-85 interleukin 1 beta Rattus norvegicus 133-150 19171179-9 2009 Incubation with both LPS and IL-1beta further attenuated nicotine-induced Ca(2+) response. Nicotine 57-65 interleukin 1 beta Rattus norvegicus 29-37 19171179-10 2009 We also found that LPS and IL-1beta induced rearrangement of the F-actin filaments, as measured with an Alexa488-conjugated phalloidin probe. alexa488 104-112 interleukin 1 beta Rattus norvegicus 27-35 19171179-10 2009 We also found that LPS and IL-1beta induced rearrangement of the F-actin filaments, as measured with an Alexa488-conjugated phalloidin probe. Phalloidine 124-134 interleukin 1 beta Rattus norvegicus 27-35 19171179-12 2009 These results indicate that there is a connection between a dysfunction of nicotine Ca(2+) signaling in inflammatory reactive astrocytes and upregulation of IL-1beta and the rearrangements of actin filaments in the cells. Nicotine 75-83 interleukin 1 beta Rattus norvegicus 157-165 19595066-0 2009 [Glutamine inhibits interleukin-1beta induced nitric oxide production and inducible nitric oxide synthase expression: experiment with cultured rat hepatocytes]. Nitric Oxide 46-58 interleukin 1 beta Rattus norvegicus 20-37 19070602-5 2009 Four days after DNBS administration, colon TNF-alpha and IL-1beta productions were increased, associated with colon damage. dinitrobenzenesulfonic acid 16-20 interleukin 1 beta Rattus norvegicus 57-65 18554967-7 2009 RESULTS: Tibia fracture chronically up-regulated TNFalpha, IL-1beta and IL-6 mRNA and protein levels in hindpaw skin and PTX treatment significantly reduced the mRNA expression and cytokine protein levels for all these cytokines. Pentoxifylline 121-124 interleukin 1 beta Rattus norvegicus 59-67 19054775-0 2009 Effect of L-dopa on interleukin-1 beta-induced suppression of luteinizing hormone secretion in intact female rats. Levodopa 10-16 interleukin 1 beta Rattus norvegicus 20-38 19054775-1 2009 BACKGROUND: The cytokine, interleukin-1 beta (IL-1 beta), increases during immune stress and is known to suppress the preovulatory luteinizing hormone (LH) surge in female rats by decreasing hypothalamic norepinephrine (NE). Norepinephrine 204-218 interleukin 1 beta Rattus norvegicus 26-44 19054775-1 2009 BACKGROUND: The cytokine, interleukin-1 beta (IL-1 beta), increases during immune stress and is known to suppress the preovulatory luteinizing hormone (LH) surge in female rats by decreasing hypothalamic norepinephrine (NE). Norepinephrine 204-218 interleukin 1 beta Rattus norvegicus 46-55 19054775-10 2009 IL-1 beta treatment caused failure of ovulation and this effect was also reversed by L-dopa. Levodopa 85-91 interleukin 1 beta Rattus norvegicus 0-9 19067786-7 2009 Further melatonin repressed the upregulated levels of expression of proinflammatory cytokines like, TNF-alpha, IL-1beta and IL-6 in RE. Melatonin 8-17 interleukin 1 beta Rattus norvegicus 111-119 19061541-11 2009 Minocycline reduced thrombin-induced up-regulation of tumor necrosis factor-alpha and interleukin-1beta. Minocycline 0-11 interleukin 1 beta Rattus norvegicus 86-103 19061541-13 2009 DISCUSSION: Thrombin stimulates microglia to release the pro-inflammatory cytokines, tumor necrosis factor-alpha and interleukin-1beta, and microglial inhibition with minocycline reduces brain injury after intracerebral hemorrhage, suggesting a critical role of microglia activation in intracerebral hemorrhage-related brain injury. Minocycline 167-178 interleukin 1 beta Rattus norvegicus 117-134 19190463-10 2009 Expression of monocyte chemotactic protein-1, vascular cell adhesion molecule-1, interleukin-1beta, inducible nitric oxide synthase, and matrix metalloproteinase-9 in aneurysmal walls was also inhibited by pitavastatin. pitavastatin 206-218 interleukin 1 beta Rattus norvegicus 81-98 19002429-4 2009 We have previously shown that suppressor of cytokine signalling (SOCS)-3 inhibits IL-1beta- and IFN-gamma-induced nitric oxide production in a beta cell line. Nitric Oxide 114-126 interleukin 1 beta Rattus norvegicus 82-105 18400050-8 2009 mRNA expressions of matrix metallopeptidase-9, inducible nitric oxide synthase and pro-inflammatory cytokines interleukin-1 beta and tumour necrosis factor-alpha in EAN sciatic nerves were greatly decreased by administration of minocycline as well. Minocycline 228-239 interleukin 1 beta Rattus norvegicus 110-161 19013185-9 2009 In myenteric neurons cultured without mast cells the PAR(2) agonist SLIGRL-amide, prostaglandin D(2) and interleukin (IL) 6 reduced neuronal survival while histamine, serotonin, heparin, IL1beta and tumour necrosis factor alpha had no effect; corticosteroid and VIP enhanced neuronal survival. Prostaglandins D 82-97 interleukin 1 beta Rattus norvegicus 187-194 19270356-4 2009 RESULTS: Apoptosis index (AI), the protein level and the mRNA expression of TNF-alpha and IL-1beta were significantly higher in the I/R group than those of Group S. Pre-administration of sevoflurane could inhibit the increase of the protein level and the expression of mRNA of TNF-alpha, and IL-1beta and attenuate the cerebral damage induced by ischemia-reperfusion. Sevoflurane 187-198 interleukin 1 beta Rattus norvegicus 90-98 19270356-4 2009 RESULTS: Apoptosis index (AI), the protein level and the mRNA expression of TNF-alpha and IL-1beta were significantly higher in the I/R group than those of Group S. Pre-administration of sevoflurane could inhibit the increase of the protein level and the expression of mRNA of TNF-alpha, and IL-1beta and attenuate the cerebral damage induced by ischemia-reperfusion. Sevoflurane 187-198 interleukin 1 beta Rattus norvegicus 292-300 19270356-7 2009 CONCLUSION: Sevoflurane can produce delayed protection against cerebral ischemia-reperfusion injury by down-regulating TNF-alpha, IL-1beta protein, and mRNA expression. Sevoflurane 12-23 interleukin 1 beta Rattus norvegicus 130-138 19028472-5 2009 MEL exposure modulated the mitotic and apoptotic indices in the colonic adenocarcinomas that developed and lowered the immunohistochemical expression of nuclear factor kappa B, tumor necrosis factor alpha, interleukin-1beta and STAT3 in the epithelial malignancies. Melatonin 0-3 interleukin 1 beta Rattus norvegicus 206-223 19027145-3 2009 In the control and levosimendan groups, cecal ligation and puncture resulted in moderate IL-1beta immunolabelling in lung tissue; marked IL-1beta immunolabelling was demonstrated in the dobutamine group. Dobutamine 186-196 interleukin 1 beta Rattus norvegicus 137-145 18983910-7 2009 Furthermore, in ligature-induced periodontitis lesions, gene expression encoding inflammation, including interleukin-1 alpha and interleukin-1 beta, was more than twofold down-regulated by vitamin C intake. Ascorbic Acid 189-198 interleukin 1 beta Rattus norvegicus 129-147 19129380-9 2009 EPA also reduced serum concentrations of IL-1beta and PGE2, but reversed NGF reduction. eicosapentaenoic acid ethyl ester 0-3 interleukin 1 beta Rattus norvegicus 41-49 19129380-10 2009 Similar to the effects of EPA, the anti-inflammatory drug celecoxib significantly reduced blood PGE2, IL-1beta, and corticosterone concentrations and increased NGF expression in OB rats. Celecoxib 58-67 interleukin 1 beta Rattus norvegicus 102-110 19014915-0 2009 Interaction between GABA and norepinephrine in interleukin-1beta-induced suppression of the luteinizing hormone surge. gamma-Aminobutyric Acid 20-24 interleukin 1 beta Rattus norvegicus 47-64 19014915-0 2009 Interaction between GABA and norepinephrine in interleukin-1beta-induced suppression of the luteinizing hormone surge. Norepinephrine 29-43 interleukin 1 beta Rattus norvegicus 47-64 19014915-13 2009 The GABA-A receptor antagonist, bicuculline, was able to reverse the effect of IL-1beta on NE and LH, while the GABA-B receptor antagonist, CGP 35348 was without any effect. Bicuculline 32-43 interleukin 1 beta Rattus norvegicus 79-87 19014915-14 2009 This leads us to conclude that the IL-1beta-induced suppression of the LH surge is most probably mediated through an increase in GABA levels in the MPA which causes a reduction in NE levels. gamma-Aminobutyric Acid 129-133 interleukin 1 beta Rattus norvegicus 35-43 19081643-0 2009 Tumor necrosis factor-alpha, interleukin-1beta and nitric oxide induce calcium transients in distinct populations of cells cultured from the rat area postrema. Calcium 71-78 interleukin 1 beta Rattus norvegicus 29-46 18824844-8 2009 The analysis of mRNA expressions of Th1 (t-bet, TNF-alpha, IL-1beta) and Th2 (gata-3, IL-4, IL-10) cytokines showed a Th1-polarized response in Gly-AKI rats that was aggravated with the anti-HGF treatment. Glycine 144-147 interleukin 1 beta Rattus norvegicus 59-67 19655406-9 2009 In addition, EPS (2.25, 4.5 g/kg, ig 9 days) inhibited the expression of TNF-alpha and IL-1beta and the biological activity of NF-kappaB. exophthalmos producing substance 13-16 interleukin 1 beta Rattus norvegicus 87-95 19183878-0 2009 The inhibitory effects of cholalic acid and hyodeoxycholalic acid on the expression of TNFalpha and IL-1beta after cerebral ischemia in rats. Cholic Acids 26-39 interleukin 1 beta Rattus norvegicus 100-108 19327174-9 2009 Piperine inhibited the migration of activator protein 1 (AP-1), but not nuclear factor (NF)kappaB, into the nucleus in IL1beta-treated synoviocytes. piperine 0-8 interleukin 1 beta Rattus norvegicus 119-126 19586548-7 2009 Intrathecal IL-1beta increased spinal cord wind-up activity in normal and monoarthritic rats without propentofylline pre-treatment, but resulted in decreased wind-up activity in normal and monoarthritic propentofylline-treated animals. propentofylline 101-116 interleukin 1 beta Rattus norvegicus 12-20 19586548-7 2009 Intrathecal IL-1beta increased spinal cord wind-up activity in normal and monoarthritic rats without propentofylline pre-treatment, but resulted in decreased wind-up activity in normal and monoarthritic propentofylline-treated animals. propentofylline 203-218 interleukin 1 beta Rattus norvegicus 12-20 18710439-7 2009 The levels of inflammation-related transcripts including inducible NO synthase (iNOS), interleukin-1beta and tumour necrosis factor-alpha, induced by CYP, were down-regulated significantly by pretreatment with rolipram. Rolipram 210-218 interleukin 1 beta Rattus norvegicus 87-137 19183878-0 2009 The inhibitory effects of cholalic acid and hyodeoxycholalic acid on the expression of TNFalpha and IL-1beta after cerebral ischemia in rats. hyodeoxycholalic acid 44-65 interleukin 1 beta Rattus norvegicus 100-108 19276636-11 2009 In vitro studies showed that muscovite had a dose-dependent adsorption of TNF-alpha and IL-1beta. muscovite 29-38 interleukin 1 beta Rattus norvegicus 88-96 19893089-10 2009 The peak levels of TNF-alpha and IL-1beta were significantly suppressed by simvastatin, compared to control rats only treated with dimethylsulfoxide before LPS. Simvastatin 75-86 interleukin 1 beta Rattus norvegicus 33-41 18987305-4 2009 Here, in both cultured cells and freshly isolated rat cortical collecting duct, aldosterone activated the canonical NF-kappaB signaling pathway, leading to increased expression of several NF-kappaB-targeted genes (IkappaBalpha, plasminogen activator inhibitor 1, monocyte chemoattractant protein 1, IL-1beta, and IL-6). Aldosterone 80-91 interleukin 1 beta Rattus norvegicus 299-307 19893089-12 2009 Simvastatin pretreatment given orally produced acute anti-inflammatory effects by inhibiting TNF-alpha and IL-1beta, but no IL-6 production. Simvastatin 0-11 interleukin 1 beta Rattus norvegicus 107-115 18435714-8 2009 Reduced alanine aminotransferase (ALT) levels and blunted expression of inflammatory factors [tumour necrosis factor-alpha, interleukin (IL)-1beta and IL-6] were seen in the liver of BDL-treated rats that received celecoxib at week 1. Celecoxib 214-223 interleukin 1 beta Rattus norvegicus 124-146 18841529-6 2009 Shortly after ovariectomy (at 3 d) serum interleukin-1beta levels significantly increased in ovariectomized rats, treated or not with estradiol, while serum interleukin-10 levels increased only 9 d after ovariectomy. Estradiol 134-143 interleukin 1 beta Rattus norvegicus 41-58 19521107-8 2009 CONCLUSION: We found that DHEA pretreatment alters renal IL-1beta, IL-6 and VEGF synthesis. Dehydroepiandrosterone 26-30 interleukin 1 beta Rattus norvegicus 57-65 19609086-14 2009 Activated expression of IL-1beta in nARC suggests its role in keeping AA-induced anorexia in progress. narc 36-40 interleukin 1 beta Rattus norvegicus 24-32 19484971-7 2009 mRNAs encoding IL-1beta and TNFalpha were increased, which were reduced to normal levels after insulin and gliclazide treatment. Gliclazide 107-117 interleukin 1 beta Rattus norvegicus 15-23 19212441-1 2009 Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both epinephrine and norepinephrine directly activate NFkappaB in macrophages, causing enhanced release of proinflammatory cytokines (TNFalpha, IL-1beta, IL-6). Epinephrine 157-168 interleukin 1 beta Rattus norvegicus 296-304 19212441-1 2009 Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both epinephrine and norepinephrine directly activate NFkappaB in macrophages, causing enhanced release of proinflammatory cytokines (TNFalpha, IL-1beta, IL-6). Norepinephrine 173-187 interleukin 1 beta Rattus norvegicus 296-304 18836210-8 2009 We found that manganese upregulated inducible nitric oxide synthase (iNOS) and tumor necrosis factor alpha (TNF-alpha) gene expression, as well as iNOS, TNF-alpha, and interleukin-1beta (IL-1beta) protein levels in the SN. Manganese 14-23 interleukin 1 beta Rattus norvegicus 168-185 18836210-8 2009 We found that manganese upregulated inducible nitric oxide synthase (iNOS) and tumor necrosis factor alpha (TNF-alpha) gene expression, as well as iNOS, TNF-alpha, and interleukin-1beta (IL-1beta) protein levels in the SN. Manganese 14-23 interleukin 1 beta Rattus norvegicus 187-195 18836210-9 2009 Furthermore, treatment with minocycline, an inhibitor of microglial activation, attenuated microglial activation and mitigated IL-1beta, TNF-alpha, and iNOS production as well as dopaminergic neurotoxicity induced by manganese. Minocycline 28-39 interleukin 1 beta Rattus norvegicus 127-135 19091115-3 2008 RESULTS: Examination of the cultures with confocal Fluo-4 AM imaging showed that IL-1beta increased the change in intracellular Ca(2+) produced by exposure to 35-50 mM K+. Fluo 4 51-57 interleukin 1 beta Rattus norvegicus 81-89 19004508-0 2008 Triptolide inhibits amyloid-beta1-42-induced TNF-alpha and IL-1beta production in cultured rat microglia. triptolide 0-10 interleukin 1 beta Rattus norvegicus 59-67 19004508-4 2008 Pretreatment of the cultures with triptolide, an anti-inflammatory reagent, alleviated the elevation of TNF-alpha and IL-1beta level induced by oligomeric Abeta1-42. triptolide 34-44 interleukin 1 beta Rattus norvegicus 118-126 19120138-5 2008 HPA axis responses to IL-1beta and CCK can be reinstated in pregnant rats by systemic administration of the opioid receptor antagonist naloxone, and when infused directly into the PVN, naloxone restores noradrenaline release in the PVN following IL-1beta treatment. Naloxone 185-193 interleukin 1 beta Rattus norvegicus 246-254 19026158-8 2008 Significantly, treatment of aged rats with SF (100 mg/kg and 200 mg/kg per day) for 4 weeks prevented the agerelated increase in IL-1beta and IL-1beta-induced JNK signaling pathway and also the age-related changes in ERK and Akt kinase. ferulic acid 43-45 interleukin 1 beta Rattus norvegicus 129-137 19026158-8 2008 Significantly, treatment of aged rats with SF (100 mg/kg and 200 mg/kg per day) for 4 weeks prevented the agerelated increase in IL-1beta and IL-1beta-induced JNK signaling pathway and also the age-related changes in ERK and Akt kinase. ferulic acid 43-45 interleukin 1 beta Rattus norvegicus 142-150 19120138-3 2008 Forced swimming, systemic interleukin-1beta (IL-1beta), and cholecystokinin (CCK) all activate brain stem noradrenergic cell groups, stimulate noradrenaline release in the PVN, and activate the HPA axis in nonpregnant rats. Norepinephrine 143-156 interleukin 1 beta Rattus norvegicus 26-43 19120138-3 2008 Forced swimming, systemic interleukin-1beta (IL-1beta), and cholecystokinin (CCK) all activate brain stem noradrenergic cell groups, stimulate noradrenaline release in the PVN, and activate the HPA axis in nonpregnant rats. Norepinephrine 143-156 interleukin 1 beta Rattus norvegicus 45-53 19120138-5 2008 HPA axis responses to IL-1beta and CCK can be reinstated in pregnant rats by systemic administration of the opioid receptor antagonist naloxone, and when infused directly into the PVN, naloxone restores noradrenaline release in the PVN following IL-1beta treatment. Naloxone 135-143 interleukin 1 beta Rattus norvegicus 22-30 19120138-5 2008 HPA axis responses to IL-1beta and CCK can be reinstated in pregnant rats by systemic administration of the opioid receptor antagonist naloxone, and when infused directly into the PVN, naloxone restores noradrenaline release in the PVN following IL-1beta treatment. Naloxone 135-143 interleukin 1 beta Rattus norvegicus 246-254 19120138-5 2008 HPA axis responses to IL-1beta and CCK can be reinstated in pregnant rats by systemic administration of the opioid receptor antagonist naloxone, and when infused directly into the PVN, naloxone restores noradrenaline release in the PVN following IL-1beta treatment. Naloxone 185-193 interleukin 1 beta Rattus norvegicus 22-30 19120138-5 2008 HPA axis responses to IL-1beta and CCK can be reinstated in pregnant rats by systemic administration of the opioid receptor antagonist naloxone, and when infused directly into the PVN, naloxone restores noradrenaline release in the PVN following IL-1beta treatment. Norepinephrine 203-216 interleukin 1 beta Rattus norvegicus 22-30 18802725-2 2008 Lactate production is hormonally regulated by follicle-stimulating hormone (FSH) and by a large set of intratesticular regulators such as interleukin-1 beta (IL1 beta) and basic fibroblast growth factor (bFGF). Lactic Acid 0-7 interleukin 1 beta Rattus norvegicus 138-156 19180878-0 2008 Effect of interleukin-1 beta on growth hormone gene expression and its possible molecular mechanism in rat MtT/S somatotroph cells. monooxyethylene trimethylolpropane tristearate 107-110 interleukin 1 beta Rattus norvegicus 10-28 19180878-10 2008 CONCLUSIONS: IL-1 beta promotes GH secretion and synthesis in rat MtT/S somatotroph cells. monooxyethylene trimethylolpropane tristearate 66-69 interleukin 1 beta Rattus norvegicus 13-22 18584332-2 2008 However, we previously reported that serum levels of LPS-induced tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) are potentiated during morphine tolerance due to the HPA axis desensitization. Morphine 184-192 interleukin 1 beta Rattus norvegicus 106-123 18584332-2 2008 However, we previously reported that serum levels of LPS-induced tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) are potentiated during morphine tolerance due to the HPA axis desensitization. Morphine 184-192 interleukin 1 beta Rattus norvegicus 125-133 18791746-4 2008 Anti-inflammatory effects of simvastatin were studied by evaluating the expression of the inflammatory mediators interleukin-1 beta (IL-1beta), transforming growth factor-beta1 (TGF-beta1), and transcription factor nuclear factor kappa B (NF-kappaB). Simvastatin 29-40 interleukin 1 beta Rattus norvegicus 113-131 18791746-4 2008 Anti-inflammatory effects of simvastatin were studied by evaluating the expression of the inflammatory mediators interleukin-1 beta (IL-1beta), transforming growth factor-beta1 (TGF-beta1), and transcription factor nuclear factor kappa B (NF-kappaB). Simvastatin 29-40 interleukin 1 beta Rattus norvegicus 133-141 18791746-6 2008 Simvastatin significantly decreases IL-1beta and TGF-beta1 expression and NF-kappaB activation, accompanied by significant attenuation of glomerulosclerosis and renal function at 12 weeks after ADR injection, and these changes occurred in the absence of lowering of serum lipids. Simvastatin 0-11 interleukin 1 beta Rattus norvegicus 36-44 18791746-8 2008 The beneficial effect of simvastatin might be mediated by the effect of anti-inflammatory action through a reduction of NF-kappaB activation, and IL-1beta and TGF-beta expression. Simvastatin 25-36 interleukin 1 beta Rattus norvegicus 146-154 19260320-5 2008 CONCLUSION: JDTL injection had inhibiting effect on TNF-alpha, IL1-beta, MCP-1 as well as ICMA-1 caused by cerebral ischemia, the result suggested that JDIL injection can protect cerebral tissue from ischemic injury by inhibiting inflammatory factors. jdtl 12-16 interleukin 1 beta Rattus norvegicus 63-71 19260320-5 2008 CONCLUSION: JDTL injection had inhibiting effect on TNF-alpha, IL1-beta, MCP-1 as well as ICMA-1 caused by cerebral ischemia, the result suggested that JDIL injection can protect cerebral tissue from ischemic injury by inhibiting inflammatory factors. jdil 152-156 interleukin 1 beta Rattus norvegicus 63-71 18782565-5 2008 Sinomenine suppressed the production of proinflammatory cytokines IL-1beta and IL-6 in serum, inhibited the protein expressions and activities of MMP-2 and MMP-9, and elevated the protein expressions and activities of TIMP-1 and TIMP-3 in rat paw tissues. sinomenine 0-10 interleukin 1 beta Rattus norvegicus 66-74 18787523-7 2008 Plasma levels and heart expression of IL-1 beta, IL-6, and TNF-alpha showed an increase in the L-NAME group, which was reversed by LC treatment. NG-Nitroarginine Methyl Ester 95-101 interleukin 1 beta Rattus norvegicus 38-47 19037001-11 2008 IL-1beta caused depletion of intracellular ATP, loss of mitochondrial transmembrane potential, caspase-3/7 activation, and LDH release. Adenosine Triphosphate 43-46 interleukin 1 beta Rattus norvegicus 0-8 19037001-12 2008 IL-1beta treatment increased rates of glucose utilization and lactate production. Glucose 38-45 interleukin 1 beta Rattus norvegicus 0-8 19037001-12 2008 IL-1beta treatment increased rates of glucose utilization and lactate production. Lactic Acid 62-69 interleukin 1 beta Rattus norvegicus 0-8 19037001-13 2008 The cells were partially protected from IL-1beta toxicity by ample ambient glucose. Glucose 75-82 interleukin 1 beta Rattus norvegicus 40-48 19037001-15 2008 IL-1beta decreased oxygen consumption of the R28 cells by nearly half, but did not lower cytochrome c oxidase activity. Oxygen 19-25 interleukin 1 beta Rattus norvegicus 0-8 18524010-0 2008 The effect of hyaluronic acid on IL-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis. Hyaluronic Acid 14-29 interleukin 1 beta Rattus norvegicus 33-41 18524010-1 2008 The purpose of this article was to study the effect of hyaluronic acid (HA) on chondrocyte apoptosis in a rat osteoarthritis in vitro model (exposure to IL-1beta) and explore its mechanism. Hyaluronic Acid 55-70 interleukin 1 beta Rattus norvegicus 153-161 18524010-1 2008 The purpose of this article was to study the effect of hyaluronic acid (HA) on chondrocyte apoptosis in a rat osteoarthritis in vitro model (exposure to IL-1beta) and explore its mechanism. Hyaluronic Acid 72-74 interleukin 1 beta Rattus norvegicus 153-161 18791062-9 2008 Desipramine at the dose of 20 mg/kg produced more decrease in the level of TNF-alpha compared with the effect of the smaller dose, but fluoxetine at 10 mg/kg diminished more in the level of IL-1beta compared with the effect of the larger dose. Fluoxetine 135-145 interleukin 1 beta Rattus norvegicus 190-198 19141974-12 2008 RESULTS: Six hours after the infusion of LPS (T(1)), the plasma concentrations of TNF-alpha, IL-1beta, and IL-8 were much lower in the Ala-Gln treated group and the Gln treated group than those in the LPS-induced shock group (P<0.05). alanylglutamine 135-142 interleukin 1 beta Rattus norvegicus 93-101 18973600-9 2008 Analyses using real-time RT-PCR indicated that inactivation of the BLA blocked the suppressive effect of heroin-associated environmental stimuli on iNOS induction and on the expression of the proinflammatory cytokines TNF-alpha and IL-1beta in spleen and liver tissue. Heroin 105-111 interleukin 1 beta Rattus norvegicus 232-240 18802725-2 2008 Lactate production is hormonally regulated by follicle-stimulating hormone (FSH) and by a large set of intratesticular regulators such as interleukin-1 beta (IL1 beta) and basic fibroblast growth factor (bFGF). Lactic Acid 0-7 interleukin 1 beta Rattus norvegicus 158-166 18573161-12 2008 Significant rice in IL-10 and reductions in the iNOS, HO-1, IL-6, TNF-alpha and IL-1beta protein expression were also found in rats treated with melatonin. Melatonin 145-154 interleukin 1 beta Rattus norvegicus 80-88 18752652-1 2008 Interleukin (IL)-1beta is present throughout the magnocellular neuroendocrine system and co-depletes with oxytocin and vasopressin from the neural lobe during salt-loading. Salts 159-163 interleukin 1 beta Rattus norvegicus 0-22 18752652-6 2008 In response to osmotic stimulation, IL-1beta increased progressively in dialysates of the SON area by a mechanism dependent on intracellular Ca2+ stores sensitive to thapsigargin and, similar to dendritic secretion of oxytocin and vasopressin, required local voltage-gated Na+ and Ca2+ channels for activation by osmoregulatory pathways from the forebrain. Thapsigargin 166-178 interleukin 1 beta Rattus norvegicus 36-44 18694623-0 2008 Activation of interleukin-1beta receptor suppresses the voltage-gated potassium currents in the small-diameter trigeminal ganglion neurons following peripheral inflammation. Potassium 70-79 interleukin 1 beta Rattus norvegicus 14-31 18500552-7 2008 Compared with chronic vehicle, chronic NMDA significantly increased protein and mRNA levels of interleukin-1beta, tumor necrosis factor alpha, glial fibrillary acidic protein and inducible nitric oxide synthase. N-Methylaspartate 39-43 interleukin 1 beta Rattus norvegicus 95-141 19033105-4 2008 RESULTS: AngII induced TNF-alpha and IL-1beta secretion from the hypertrophied cardiomyocyets, and pretreatment of the cells with PD123319, but not losartan, decreased their secretion. PD 123319 130-138 interleukin 1 beta Rattus norvegicus 37-45 18722361-4 2008 Treatment of co-cultures with the excitotoxin N-methyl-D-aspartate (NMDA) induced neuronal cell death leading to the appearance of pro-IL-1beta in the culture supernatant. N-Methylaspartate 46-66 interleukin 1 beta Rattus norvegicus 135-143 18722361-4 2008 Treatment of co-cultures with the excitotoxin N-methyl-D-aspartate (NMDA) induced neuronal cell death leading to the appearance of pro-IL-1beta in the culture supernatant. N-Methylaspartate 68-72 interleukin 1 beta Rattus norvegicus 135-143 18827362-0 2008 Troglitazone increases IL-1beta induced cyclooxygenase-2 and inducible nitric oxide synthase expression via enhanced phosphorylation of IkappaBalpha in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats. Troglitazone 0-12 interleukin 1 beta Rattus norvegicus 23-31 18923025-8 2008 Neutralization of endogenous TNF-alpha and IL-1beta in the RVM significantly reduced CCI-induced behavioral hypersensitivity and attenuated NR1 phosphorylation. CCI 85-88 interleukin 1 beta Rattus norvegicus 43-51 18821705-8 2008 The positive correlation between hypothalamic IL-1beta expression and noradrenaline content in control groups was not observed in rats in which arthritis developed. Norepinephrine 70-83 interleukin 1 beta Rattus norvegicus 46-54 18827362-5 2008 Troglitazone treatment of these cells also resulted in a dose-dependent increase in IL-1beta induced IkappaBalpha phosphorylation. Troglitazone 0-12 interleukin 1 beta Rattus norvegicus 84-92 18827362-6 2008 These data suggest that troglitazone is capable of increasing IL-1beta induced COX-2 and iNOS expression through an IkappaBalpha dependent mechanism in VSMC from WKY and SHR. Troglitazone 24-36 interleukin 1 beta Rattus norvegicus 62-70 18827362-3 2008 We report here that troglitazone but not ciglitazone increased IL-1beta induced cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression in vascular smooth muscle cell (VSMC) from Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). Troglitazone 20-32 interleukin 1 beta Rattus norvegicus 63-71 18054352-13 2008 The mRNA of metalloproteinases, interleukin-1beta, interleukin-1r, prostaglandin E synthase (Ptges), and nuclear factor (NF)-kappaB were reduced in the EPA group. Eicosapentaenoic Acid 152-155 interleukin 1 beta Rattus norvegicus 32-49 18796608-3 2008 We found that epigallocatechin-3-gallate (EGCG), an anti-inflammatory compound found in green tea, inhibits IL-1beta-induced IL-6 production and transsignaling in RA synovial fibroblasts by inducing alternative splicing of gp130 mRNA, resulting in enhanced sgp130 production. epigallocatechin gallate 14-40 interleukin 1 beta Rattus norvegicus 108-116 18393970-7 2008 In contrast, AM404 inhibited LPS-induced increases in circulating interleukin-1beta (IL-1beta) and IL-6. N-(4-hydroxyphenyl)arachidonylamide 13-18 interleukin 1 beta Rattus norvegicus 66-83 18393970-7 2008 In contrast, AM404 inhibited LPS-induced increases in circulating interleukin-1beta (IL-1beta) and IL-6. N-(4-hydroxyphenyl)arachidonylamide 13-18 interleukin 1 beta Rattus norvegicus 85-93 18393970-8 2008 AM251 attenuated the immunosuppressive effect of AM404 on IL-1beta. N-(4-hydroxyphenyl)arachidonylamide 49-54 interleukin 1 beta Rattus norvegicus 58-66 18393970-12 2008 The immunosuppressive effect of AM404 on IL-1beta levels is mediated by the cannabinoid CB1 receptor. N-(4-hydroxyphenyl)arachidonylamide 32-37 interleukin 1 beta Rattus norvegicus 41-49 18929807-16 2008 The GLN-treated group showed attenuated IL-1beta-induced injury in association with NO production. Glutamine 4-7 interleukin 1 beta Rattus norvegicus 40-48 18929807-17 2008 CONCLUSION: These results suggested that preoperative GLN administration induced HSP70 and GSH expressions before islet transplantation, thus attenuating IL-1beta-induced injury in association with NO production and apoptosis, which might be potential tool to mitigate the ischemic damage to islet cells and the early inflammation at the site of implantation through a self-protective mechanism. Glutamine 54-57 interleukin 1 beta Rattus norvegicus 154-162 18687386-0 2008 Exogenous corticosterone reduces L-DOPA-induced dyskinesia in the hemi-parkinsonian rat: role for interleukin-1beta. Corticosterone 10-24 interleukin 1 beta Rattus norvegicus 98-115 18687386-9 2008 Real-time reverse-transcription polymerase chain reaction of striatal tissue implicated a role for interleukin-1 (IL-1) beta in these effects as its expression was increased on the lesioned side in rats treated with l-DOPA (within the DA-depleted striatum) and attenuated with CORT. Levodopa 216-222 interleukin 1 beta Rattus norvegicus 114-124 18796608-3 2008 We found that epigallocatechin-3-gallate (EGCG), an anti-inflammatory compound found in green tea, inhibits IL-1beta-induced IL-6 production and transsignaling in RA synovial fibroblasts by inducing alternative splicing of gp130 mRNA, resulting in enhanced sgp130 production. epigallocatechin gallate 42-46 interleukin 1 beta Rattus norvegicus 108-116 18591261-6 2008 Dex also programmed increased plasma tumour necrosis factor alpha and interleukin 1 beta (IL-1 beta), but the increase in IL-1 beta was also prevented by the Hn3 diet. Dexamethasone 0-3 interleukin 1 beta Rattus norvegicus 70-88 18606162-2 2008 Adenosine significantly inhibited interferon-gamma (IFN-gamma)+interleukin-1beta (IL-1beta)-induced synthesis of iNOS mRNA/protein and subsequent production of NO in C6 cells. Adenosine 0-9 interleukin 1 beta Rattus norvegicus 63-80 18606162-2 2008 Adenosine significantly inhibited interferon-gamma (IFN-gamma)+interleukin-1beta (IL-1beta)-induced synthesis of iNOS mRNA/protein and subsequent production of NO in C6 cells. Adenosine 0-9 interleukin 1 beta Rattus norvegicus 82-90 18606162-4 2008 Adenosine also blocked the IFN-gamma+IL-1beta-triggered expression of mRNA for the proinflammatory cytokine TNF-alpha, while it significantly enhanced the accumulation of cyclooxygenase-2 (COX-2) mRNA in glioma cells. Adenosine 0-9 interleukin 1 beta Rattus norvegicus 37-45 18806959-6 2008 The expressions of TNF-alpha, IL-1beta, IL-6, and iNOS were increased by CCl(4) treatment and increased expressions of those were decreased by morin. Cefaclor 73-76 interleukin 1 beta Rattus norvegicus 30-38 18777114-6 2008 CONCLUSIONS: LXA(4) inhibits synthesis of IL-1beta, IL-6 and IL-8 in PMVEC and this antagonism is related to PI3-K, p38 and p42/44 MAPK, NF-kappaB and AP-1 pathway-dependent signal transduction. lipoxin A4 13-19 interleukin 1 beta Rattus norvegicus 42-50 18053091-0 2008 Regulatory roles for histone deacetylation in IL-1beta-induced nitric oxide release in pancreatic beta-cells. Nitric Oxide 63-75 interleukin 1 beta Rattus norvegicus 46-54 18053091-2 2008 Herein, we investigated potential roles for histone deacetylation (or hypoacetylation) in interleukin-1beta (IL-1beta)-mediated inducible nitric oxide synthase (iNOS) and nitric oxide (NO) release in insulin-secreting INS 832/13 (INS) cells. Nitric Oxide 138-150 interleukin 1 beta Rattus norvegicus 90-107 18053091-2 2008 Herein, we investigated potential roles for histone deacetylation (or hypoacetylation) in interleukin-1beta (IL-1beta)-mediated inducible nitric oxide synthase (iNOS) and nitric oxide (NO) release in insulin-secreting INS 832/13 (INS) cells. Nitric Oxide 138-150 interleukin 1 beta Rattus norvegicus 109-117 18053091-4 2008 Trichostatin A (TSA), a known inhibitor of HDACs, markedly reduced IL-1beta-mediated iNOS expression and NO release from these cells in a concentration-dependent manner. trichostatin A 0-14 interleukin 1 beta Rattus norvegicus 67-75 18053091-4 2008 Trichostatin A (TSA), a known inhibitor of HDACs, markedly reduced IL-1beta-mediated iNOS expression and NO release from these cells in a concentration-dependent manner. trichostatin A 16-19 interleukin 1 beta Rattus norvegicus 67-75 18053091-5 2008 TSA also promoted hyperacetylation of histone H4 under conditions in which it inhibited IL-1beta-mediated effects on isolated beta cells. trichostatin A 0-3 interleukin 1 beta Rattus norvegicus 88-96 18053091-6 2008 Rottlerin, a known inhibitor of protein kinase Cdelta, also increased histone H4 acetylation, and inhibited IL-1beta-induced iNOS expression and NO release in these cells. rottlerin 0-9 interleukin 1 beta Rattus norvegicus 108-116 18591261-6 2008 Dex also programmed increased plasma tumour necrosis factor alpha and interleukin 1 beta (IL-1 beta), but the increase in IL-1 beta was also prevented by the Hn3 diet. Dexamethasone 0-3 interleukin 1 beta Rattus norvegicus 90-99 18718124-9 2008 Furthermore, PHCD also substantially reduced the LPS-induced TNF-alpha and IL-1beta mRNA expression and production in lung tissue and suppressed neutrophil recruitment. penehyclidine 13-17 interleukin 1 beta Rattus norvegicus 75-83 18718124-10 2008 The results suggest that PHCD attenuates LPS-induced acute lung responses through inhibition of NF-kappaB activation and LPS-induced TNF-alpha and IL-1beta production and resulting neutrophil recruitment associated with acute lung inflammation and injury. penehyclidine 25-29 interleukin 1 beta Rattus norvegicus 147-155 18448864-11 2008 Model parameters indicated that IL-6 and IL-1beta were most sensitive to inhibition by DEX. Dexamethasone 87-90 interleukin 1 beta Rattus norvegicus 41-49 18953098-0 2008 Prostaglandins and interleukin-1beta in the hypothalamic-pituitary-adrenal response to systemic phenylephrine under basal and stress conditions. Phenylephrine 96-109 interleukin 1 beta Rattus norvegicus 19-36 18953098-1 2008 We investigated the role of interleukin-1beta (IL-1beta) and prostaglandins (PG) in the alpha(1)-adrenergic agonist, phenylephrine-induced hypothalamic-pituitary-adrenal axis (HPA) responses under basal and social stress conditions. Phenylephrine 117-130 interleukin 1 beta Rattus norvegicus 28-45 18953098-1 2008 We investigated the role of interleukin-1beta (IL-1beta) and prostaglandins (PG) in the alpha(1)-adrenergic agonist, phenylephrine-induced hypothalamic-pituitary-adrenal axis (HPA) responses under basal and social stress conditions. Phenylephrine 117-130 interleukin 1 beta Rattus norvegicus 47-55 18953098-18 2008 Crowding stress for 7 days markedly impaired the IL-1beta-induced ACTH and corticosterone secretion. Corticosterone 75-89 interleukin 1 beta Rattus norvegicus 49-57 18492028-6 2008 SR58611A significantly reduced the severity of colitis as well as the tissue levels of TNF-alpha, IL-1beta and IL-6. amibegron 0-8 interleukin 1 beta Rattus norvegicus 98-106 18790178-7 2008 RESULTS: In the NM+PG group, the values of interleukin-1beta, tumor necrosis factor-alpha, and thromboxane B2 were significantly lower than those in the NHB group. nm+pg 16-21 interleukin 1 beta Rattus norvegicus 43-89 18602075-2 2008 Administration of ribavirin to EAE rats markedly affected the production of pro-inflammatory cytokines IFN-gamma, IL-1beta and TNF-alpha in DLN and spinal cord, thus shifting the balance towards the anti-inflammatory cytokines IL-10 and TGF-beta. Ribavirin 18-27 interleukin 1 beta Rattus norvegicus 114-122 18786325-10 2008 In the in vitro experiment, it was shown that rhizoma paridis total saponins in concentrations of 5, 10, 20 and 40 mg/L could inhibit remarkably the release of TNF-alpha and IL-1 beta from LPS-stimulated PMPhi of rats (all P < 0.01). Saponins 68-76 interleukin 1 beta Rattus norvegicus 174-183 18577440-7 2008 The effects of tripterine were associated with decreased interleukin-1beta (IL-1beta) mRNA expression in ankle joint synovial membrane and tumor necrosis factor-alpha (TNF-alpha) mRNA expression in homogenized paws from adjuvant-induced arthritic rats. celastrol 15-25 interleukin 1 beta Rattus norvegicus 57-74 18577440-7 2008 The effects of tripterine were associated with decreased interleukin-1beta (IL-1beta) mRNA expression in ankle joint synovial membrane and tumor necrosis factor-alpha (TNF-alpha) mRNA expression in homogenized paws from adjuvant-induced arthritic rats. celastrol 15-25 interleukin 1 beta Rattus norvegicus 76-84 18498041-8 2008 On the other hand, a chelator of intracellular free Ca(2+) [bis-(o-aminophenoxy)-N,N,N",N"-tetraacetic acid-acetoxymethyl] (BAPTA/AM) and an inhibitor of calmodulin (W7) diminished IL-1beta-induced phosphorylation of ERK. bis-(o-aminophenoxy)-n,n,n",n"-tetraacetic acid-acetoxymethyl] 60-122 interleukin 1 beta Rattus norvegicus 181-189 18498041-1 2008 Increasing evidence indicates that beta-cell apoptosis and impaired secretory function were partly mediated by interleukin (IL)-1beta and/or high-glucose-induced beta-cell production of IL-1beta. Glucose 146-153 interleukin 1 beta Rattus norvegicus 186-194 18498041-8 2008 On the other hand, a chelator of intracellular free Ca(2+) [bis-(o-aminophenoxy)-N,N,N",N"-tetraacetic acid-acetoxymethyl] (BAPTA/AM) and an inhibitor of calmodulin (W7) diminished IL-1beta-induced phosphorylation of ERK. 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid 124-129 interleukin 1 beta Rattus norvegicus 181-189 18498041-6 2008 Ca(2+) channel blocker nimodipine or ERK inhibitor PD98059 prevented glucose- and IL-1beta-induced ERK activation, beta-cell apoptosis, and impaired function. Nimodipine 23-33 interleukin 1 beta Rattus norvegicus 82-90 18498041-9 2008 Finally, islet release of IL-1beta in response to high glucose could be abrogated by nimodipine, mibefradil, or PD98059. Glucose 55-62 interleukin 1 beta Rattus norvegicus 26-34 18498041-6 2008 Ca(2+) channel blocker nimodipine or ERK inhibitor PD98059 prevented glucose- and IL-1beta-induced ERK activation, beta-cell apoptosis, and impaired function. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 51-58 interleukin 1 beta Rattus norvegicus 82-90 18498041-9 2008 Finally, islet release of IL-1beta in response to high glucose could be abrogated by nimodipine, mibefradil, or PD98059. Nimodipine 85-95 interleukin 1 beta Rattus norvegicus 26-34 18498041-7 2008 Furthermore, treatment with Ca(2+) ionophore ionomycin, or exposure to thapsigargin, an inhibitor of sarco(endo)plasmic reticulum Ca(2+) ATPase, all caused an amplification of IL-1beta-induced ERK activation in rat islet. Ionomycin 45-54 interleukin 1 beta Rattus norvegicus 176-184 18535786-6 2008 The negative inotropic effects of IL-1beta were blocked by the neutral sphingomyelinase inhibitor Manumycin A (5 microM) or the ceramidase inhibitor N-oleoyl ethanolamine (1 microM). manumycin 98-109 interleukin 1 beta Rattus norvegicus 34-42 18498041-9 2008 Finally, islet release of IL-1beta in response to high glucose could be abrogated by nimodipine, mibefradil, or PD98059. Mibefradil 97-107 interleukin 1 beta Rattus norvegicus 26-34 18535786-6 2008 The negative inotropic effects of IL-1beta were blocked by the neutral sphingomyelinase inhibitor Manumycin A (5 microM) or the ceramidase inhibitor N-oleoyl ethanolamine (1 microM). N-oleoylethanolamine 149-170 interleukin 1 beta Rattus norvegicus 34-42 18535786-7 2008 Prior exposure of myocytes to leptin blocked IL-1beta-induced cardiosuppression in conjunction with a blunting of IL-1beta stimulated ceramide accumulation. Ceramides 134-142 interleukin 1 beta Rattus norvegicus 114-122 18535786-8 2008 These data suggest that leptin may modulate IL-1beta signaling through the sphingolipid signaling pathway in cardiomyocytes. Sphingolipids 75-87 interleukin 1 beta Rattus norvegicus 44-52 18498041-7 2008 Furthermore, treatment with Ca(2+) ionophore ionomycin, or exposure to thapsigargin, an inhibitor of sarco(endo)plasmic reticulum Ca(2+) ATPase, all caused an amplification of IL-1beta-induced ERK activation in rat islet. Thapsigargin 71-83 interleukin 1 beta Rattus norvegicus 176-184 18498041-9 2008 Finally, islet release of IL-1beta in response to high glucose could be abrogated by nimodipine, mibefradil, or PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 112-119 interleukin 1 beta Rattus norvegicus 26-34 18483478-7 2008 Obese rats fed the t10c12 diet produced less TNF-alpha and IL-1beta (lippopolysaccharide (LPS), P < 0.05). lippopolysaccharide 69-88 interleukin 1 beta Rattus norvegicus 59-67 18483478-7 2008 Obese rats fed the t10c12 diet produced less TNF-alpha and IL-1beta (lippopolysaccharide (LPS), P < 0.05). lps 90-93 interleukin 1 beta Rattus norvegicus 59-67 18656620-14 2008 Cell proliferation in DMNV neurons after 24-hour exposure to the cytokines interleukin- (IL)-1 beta, IL-6, or tumor necrosis factor- (TNF)-alpha was significantly decreased. dmnv 22-26 interleukin 1 beta Rattus norvegicus 75-99 18681986-8 2008 Kainic acid up-regulated the expression of the inflammatory cytokines IL-1beta and TNF-alpha, the neurotrophic factor IGF-1, and the transcription factor NF-kappaB. Kainic Acid 0-11 interleukin 1 beta Rattus norvegicus 70-78 18681986-9 2008 Blueberry and piroxicam supplementations were found to attenuate the kainic acid-induced increase in the expression of IL-1beta, TNF-alpha, and NF-kappaB, while only blueberry was able to augment the increased IGF-1 expression. Kainic Acid 69-80 interleukin 1 beta Rattus norvegicus 119-127 18795653-4 2008 Furthermore, in vitro CINC production by isolated liver cells from obstructive jaundice (OJ) liver or sham-treated liver was evaluated after stimulation with tumor necrosis factor-alpha (TNFalpha), interleukin-1beta (IL-1beta) or LPS. Zinc 22-26 interleukin 1 beta Rattus norvegicus 198-215 18487441-8 2008 With the exception of plasma IL-1beta, an indicator of peripheral proinflammatory cytokine activity, all measures of neurohumoral excitation were significantly lower in HF rats treated with intracerebroventricular PTX. Pentoxifylline 214-217 interleukin 1 beta Rattus norvegicus 29-37 18487443-6 2008 Isoproterenol enhanced aortic mRNA and protein expression of IL-1beta (124% and 125%) and IL-6 (231% and 40%) compared with controls but did not change TNF-alpha expression. Isoproterenol 0-13 interleukin 1 beta Rattus norvegicus 61-69 18343024-3 2008 Therefore, in this study, the effect of guggulsterone on IL-1beta- and IFN-gamma-induced beta-cell damage was investigated. pregna-4,17-diene-3,16-dione 40-53 interleukin 1 beta Rattus norvegicus 57-80 18343024-4 2008 Treatment of RINm5F (RIN) rat insulinoma cells with IL-1beta and IFN-gamma induced cell damage, and this damage was well correlated with nitric oxide (NO) and prostaglandin E2 (PGE2) production. Nitric Oxide 137-149 interleukin 1 beta Rattus norvegicus 52-60 18343024-4 2008 Treatment of RINm5F (RIN) rat insulinoma cells with IL-1beta and IFN-gamma induced cell damage, and this damage was well correlated with nitric oxide (NO) and prostaglandin E2 (PGE2) production. Dinoprostone 159-175 interleukin 1 beta Rattus norvegicus 52-60 18343024-4 2008 Treatment of RINm5F (RIN) rat insulinoma cells with IL-1beta and IFN-gamma induced cell damage, and this damage was well correlated with nitric oxide (NO) and prostaglandin E2 (PGE2) production. Dinoprostone 177-181 interleukin 1 beta Rattus norvegicus 52-60 18371179-7 2008 Primary cultured microglial cells subjected to hypoxia (3% oxygen, 5% CO(2) and 92% nitrogen) showed enhanced expression of TNF-alpha and IL-1beta. Oxygen 59-65 interleukin 1 beta Rattus norvegicus 138-146 18371179-7 2008 Primary cultured microglial cells subjected to hypoxia (3% oxygen, 5% CO(2) and 92% nitrogen) showed enhanced expression of TNF-alpha and IL-1beta. co(2) 70-75 interleukin 1 beta Rattus norvegicus 138-146 18371179-7 2008 Primary cultured microglial cells subjected to hypoxia (3% oxygen, 5% CO(2) and 92% nitrogen) showed enhanced expression of TNF-alpha and IL-1beta. Nitrogen 84-92 interleukin 1 beta Rattus norvegicus 138-146 18795653-8 2008 In vitro study proved that CINC production by isolated hepatocytes was markedly enhanced by IL-1beta stimulation in OJ liver. Zinc 27-31 interleukin 1 beta Rattus norvegicus 92-100 18795653-11 2008 CONCLUSIONS: Excessive production of IL-1beta by activated Kupffer cells, as a result of portal endotoxemia, may play an important role for increased CINC release from hepatocytes in cholestatic liver, leading to PMN infiltration. Zinc 150-154 interleukin 1 beta Rattus norvegicus 37-45 18479673-13 2008 RSG, however, significantly attenuated MPO activity and qualitatively decreased IL-1beta and TNF-alpha expression compared to vehicle-treated group. Rosiglitazone 0-3 interleukin 1 beta Rattus norvegicus 80-88 18490106-11 2008 Additionally, treatment with selenium decreased the TNF-alpha and IL-1beta levels and increased the NGF levels in prefrontal cortex and hippocampal tissue of animals subjected to IR. Selenium 29-37 interleukin 1 beta Rattus norvegicus 66-74 18652771-4 2008 Administration of C1-INH + factor XIII and NAC + TM both resulted in reduced leucocyte adherence and reduced levels of interleukin-1beta (IL-1beta). Acetylcysteine 43-46 interleukin 1 beta Rattus norvegicus 119-136 18652771-4 2008 Administration of C1-INH + factor XIII and NAC + TM both resulted in reduced leucocyte adherence and reduced levels of interleukin-1beta (IL-1beta). Acetylcysteine 43-46 interleukin 1 beta Rattus norvegicus 138-146 18652771-7 2008 In conclusion, the administration of C1-INH + factor XIII and NAC + TM reduced endothelial leucocyte adherence and IL-1beta plasma levels, but increased IL-6 levels. Acetylcysteine 62-65 interleukin 1 beta Rattus norvegicus 115-123 18413658-6 2008 In addition, topical LXA(4) (10 ng/eye) inhibited the LPS-induced production of IL-1beta, TNF-alpha, and PGE(2), and expression of COX-2 and VEGF. N-(1H-benzimidazol-2-ylmethyl)-2-methoxyacetamide 21-24 interleukin 1 beta Rattus norvegicus 80-88 18486376-4 2008 Our study demonstrated that FBD-CO(2) prevented brain ischemia/reperfusion injury, at least in part, by limiting PMNs infiltration and neurotoxicity mediated by TNF-alpha, IL-1beta and IL-8, via inhibition on NF-kappaB activation. co(2) 32-37 interleukin 1 beta Rattus norvegicus 172-180 18444990-5 2008 It attenuated the expressions of ethanol-induced pro-inflammatory cytokines, including interleukin (IL)-1beta and interferon-gamma, a weak activation of IL-10, the inhibition of the alcohol-induced overexpression of intercellular adhesion molecule-1, and the considerable induction of heat shock protein-72 expression in gastric mucosal homogenates. Ethanol 33-40 interleukin 1 beta Rattus norvegicus 87-109 18462759-9 2008 Immunohistochemical studies revealed that DAS reduced the bleomycin-induced activation of inducible nitric oxide synthase (iNOS) and nuclear factor kappa-B (NF-kappaB) and decreased the augmented levels of the early inflammatory cytokines, tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), in the lung tissues. allyl sulfide 42-45 interleukin 1 beta Rattus norvegicus 285-302 18462759-9 2008 Immunohistochemical studies revealed that DAS reduced the bleomycin-induced activation of inducible nitric oxide synthase (iNOS) and nuclear factor kappa-B (NF-kappaB) and decreased the augmented levels of the early inflammatory cytokines, tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), in the lung tissues. allyl sulfide 42-45 interleukin 1 beta Rattus norvegicus 304-312 18462759-9 2008 Immunohistochemical studies revealed that DAS reduced the bleomycin-induced activation of inducible nitric oxide synthase (iNOS) and nuclear factor kappa-B (NF-kappaB) and decreased the augmented levels of the early inflammatory cytokines, tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), in the lung tissues. Bleomycin 58-67 interleukin 1 beta Rattus norvegicus 285-302 18462759-9 2008 Immunohistochemical studies revealed that DAS reduced the bleomycin-induced activation of inducible nitric oxide synthase (iNOS) and nuclear factor kappa-B (NF-kappaB) and decreased the augmented levels of the early inflammatory cytokines, tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), in the lung tissues. Bleomycin 58-67 interleukin 1 beta Rattus norvegicus 304-312 18496375-13 2008 Additionally, inhalation of 240 microg and infusion of 24 microg/kg levosimendan significantly reduced the release of interleukin-1beta, the nitric oxide release from alveolar macrophages, macrophage inflammatory protein-2 in plasma, and the macrophage inflammatory protein-2 and matrix metalloproteinase-9 content in bronchoalveolar lavage fluid compared with VILI only. Simendan 68-80 interleukin 1 beta Rattus norvegicus 118-135 18496380-11 2008 Moreover, hypertonic saline reduced plasma nitric oxide and interleukin-1beta and organ O2-* levels in rats that underwent cecal ligation and puncture. Sodium Chloride 21-27 interleukin 1 beta Rattus norvegicus 60-77 18496380-13 2008 These beneficial effects of hypertonic saline may be attributed to reducing the plasma concentration of nitric oxide and interleukin-1beta as well as the organ O2-* level and decreasing lung neutrophil infiltration and liver necrosis. Sodium Chloride 39-45 interleukin 1 beta Rattus norvegicus 121-138 18536735-6 2008 KEY RESULTS: BGMP pretreatment (500 mg kg(-1) day(-1)) resulted in marked reduction of inflammatory injury, as assessed by lower extension of necrosis and damage score, myeloperoxidase, alkaline phosphatase, inducible nitric oxide synthase, interleukin 1beta, tumour necrosis factor and interleukin 17. bgmp 13-17 interleukin 1 beta Rattus norvegicus 241-282 18357464-13 2008 The levels of TNF-alpha, IL-1beta and IL-6 mRNA were increased with scopolamine treatment in both conjunctiva and exorbital LG. Scopolamine 68-79 interleukin 1 beta Rattus norvegicus 25-33 18475188-10 2008 RESULTS: Compared with vehicle controls, glycine-treated graft muscularis expressed a significant alleviation in mRNA peak expression for IL-6, IL-1beta, ICAM-1, MCP-1, TNFalpha, COX-2, and iNOS. Glycine 41-48 interleukin 1 beta Rattus norvegicus 144-152 18807719-11 2008 In comparison with the corresponding time-points of model group, the number of inflammatory cells at 48 h and 72 h, plasma and cerebral TNF-alpha and IL-1beta contents at 72 h in SA group declined significantly (P<0.01). sa 179-181 interleukin 1 beta Rattus norvegicus 150-158 18315570-3 2008 Here, we first report that IL-1beta-induced up-regulation of proMMP-9 was inhibited by genistein. Genistein 87-96 interleukin 1 beta Rattus norvegicus 27-35 18441462-8 2008 MCI-186 significantly inhibited rIL-1beta-induced proliferation of smooth muscle cells from rabbit aorta, as well as the activation of NF-kappaB. Edaravone 0-7 interleukin 1 beta Rattus norvegicus 32-41 18545642-5 2008 IL-1beta was administered for ulcer recurrence after 28 weeks of acetic acid injection. Acetic Acid 65-76 interleukin 1 beta Rattus norvegicus 0-8 18545642-7 2008 ip injections of rIL-1beta (200 microg/kg) at 28 weeks after acetic acid injection led to 100% of ulcer recurrence in Group I and 75.0% in Group II, but only 16.7% of Group III rats showed ulcer recurrence. Acetic Acid 61-72 interleukin 1 beta Rattus norvegicus 17-26 18403593-6 2008 DHA significantly decreased VSMC migration/proliferation induced by interleukin-1beta as well as fibrinolytic/MMP activity. Docosahexaenoic Acids 0-3 interleukin 1 beta Rattus norvegicus 68-85 18403593-6 2008 DHA significantly decreased VSMC migration/proliferation induced by interleukin-1beta as well as fibrinolytic/MMP activity. vsmc 28-32 interleukin 1 beta Rattus norvegicus 68-85 18315570-6 2008 Moreover, IL-1beta-induced proMMP-9 expression was blocked by pre-treatment with curcumin (a p300 inhibitor). Curcumin 81-89 interleukin 1 beta Rattus norvegicus 10-18 18047562-4 2008 We evaluated TH positive neurons, astroglial, and microglial populations and found that simvastatin prevented the inflammatory processes, as the induction of interleukin-1beta, tumor necrosis factor-alpha, and iNOS and the consequent dopaminergic degeneration induced by LPS. Simvastatin 88-99 interleukin 1 beta Rattus norvegicus 158-204 18424607-0 2008 Long-chain polyunsaturated fatty acids modulate interleukin-1beta-induced changes in behavior, monoaminergic neurotransmitters, and brain inflammation in rats. long-chain polyunsaturated fatty acids 0-38 interleukin 1 beta Rattus norvegicus 48-65 18424607-2 2008 In this study, the mechanisms by which eicosapentaenoic acid (EPA), gamma-linolenic acid (GLA), and arachidonic acid (AA) modulate neurotransmitters, behavior, and brain inflammation were evaluated in rats that received central saline or interleukin-1beta (IL-1) administrations. Eicosapentaenoic Acid 62-65 interleukin 1 beta Rattus norvegicus 238-255 18424607-2 2008 In this study, the mechanisms by which eicosapentaenoic acid (EPA), gamma-linolenic acid (GLA), and arachidonic acid (AA) modulate neurotransmitters, behavior, and brain inflammation were evaluated in rats that received central saline or interleukin-1beta (IL-1) administrations. gamma-Linolenic Acid 90-93 interleukin 1 beta Rattus norvegicus 238-255 19108466-11 2008 The production of IL-1beta, IL-6, TNF-alpha was inhibited when alendronate was used. Alendronate 63-74 interleukin 1 beta Rattus norvegicus 18-26 18316064-8 2008 The injured spinal cord of 17beta-estradiol-treated rats expressed more IL-1alpha, IL-1beta and IL-6 than controls 6 h after injury. Estradiol 27-43 interleukin 1 beta Rattus norvegicus 83-91 18203872-8 2008 Conversely, hypernociception and neutrophil migration induced by TNF-alpha, IL-1beta, and CINC-1/CXCL1 was inhibited by fucoidin, suggesting that neutrophils are involved in the production of direct-acting hypernociceptive mediators. fucoidan 120-128 interleukin 1 beta Rattus norvegicus 76-84 18203872-9 2008 Indeed, neutrophils stimulated in vitro with IL-1beta produced PGE(2), and IL-1beta-induced PGE(2) production in the rat paw was inhibited by the pretreatment with fucoidin. Prostaglandins E 63-66 interleukin 1 beta Rattus norvegicus 45-53 18203872-9 2008 Indeed, neutrophils stimulated in vitro with IL-1beta produced PGE(2), and IL-1beta-induced PGE(2) production in the rat paw was inhibited by the pretreatment with fucoidin. Prostaglandins E 63-66 interleukin 1 beta Rattus norvegicus 75-83 18203872-9 2008 Indeed, neutrophils stimulated in vitro with IL-1beta produced PGE(2), and IL-1beta-induced PGE(2) production in the rat paw was inhibited by the pretreatment with fucoidin. Prostaglandins E 92-95 interleukin 1 beta Rattus norvegicus 45-53 18203872-9 2008 Indeed, neutrophils stimulated in vitro with IL-1beta produced PGE(2), and IL-1beta-induced PGE(2) production in the rat paw was inhibited by the pretreatment with fucoidin. Prostaglandins E 92-95 interleukin 1 beta Rattus norvegicus 75-83 18203872-9 2008 Indeed, neutrophils stimulated in vitro with IL-1beta produced PGE(2), and IL-1beta-induced PGE(2) production in the rat paw was inhibited by the pretreatment with fucoidin. fucoidan 164-172 interleukin 1 beta Rattus norvegicus 45-53 18203872-9 2008 Indeed, neutrophils stimulated in vitro with IL-1beta produced PGE(2), and IL-1beta-induced PGE(2) production in the rat paw was inhibited by the pretreatment with fucoidin. fucoidan 164-172 interleukin 1 beta Rattus norvegicus 75-83 18464888-6 2008 Furthermore, pre-treatment with IL-4 (10 ng/ml) suppressed both MMP-13 and cathepsin B induction by mechanical stress, as well as CTS-induced IL-1beta expression. castanospermine 130-133 interleukin 1 beta Rattus norvegicus 142-150 18081694-5 2008 The cytotoxic effect of IL-1beta/IFNgamma was associated with the expression of inducible nitric oxide synthase (iNOS) and production of nitric oxide. Nitric Oxide 90-102 interleukin 1 beta Rattus norvegicus 24-32 18081694-7 2008 The broad range caspase inhibitor, Boc-D-fmk, blocked IL-1beta/IFNgamma -induced caspase activity, but not nitric oxide production nor cell death. Boc-D-FMK 35-44 interleukin 1 beta Rattus norvegicus 54-62 17901407-5 2008 Ozone stimulated secretion of IL-1alpha, IL-1beta, and IL-18 from NR8383 cells, but there was no secretion of chemokines or TNF-alpha. Ozone 0-5 interleukin 1 beta Rattus norvegicus 41-49 18171908-0 2008 Sphingosine 1-phosphate inhibits nitric oxide production induced by interleukin-1beta in rat vascular smooth muscle cells. sphingosine 1-phosphate 0-23 interleukin 1 beta Rattus norvegicus 68-85 18171908-0 2008 Sphingosine 1-phosphate inhibits nitric oxide production induced by interleukin-1beta in rat vascular smooth muscle cells. Nitric Oxide 33-45 interleukin 1 beta Rattus norvegicus 68-85 18292427-9 2008 After ischemia, 2 and 4 h of reperfusion, tumor necrosis factor-alpha and interleukin-1beta values were lowest in the sevoflurane group and highest in the control group but it was not statistically significant (P > 0.05). Sevoflurane 118-129 interleukin 1 beta Rattus norvegicus 74-91 18309148-9 2008 In quantitative polymerase chain reaction and immunohistochemistry, simvastatin significantly inhibited upregulated expression of interleukin-1beta, inducible nitric oxide synthase, matrix metalloproteinase-2, and matrix metalloproteinase-9 associated with CA progression. Simvastatin 68-79 interleukin 1 beta Rattus norvegicus 130-147 18322229-10 2008 Furthermore, in rat bronchoalveolar lavage fluid, adenosine triggered the release of IL-6 as well as proinflammatory IL-1beta. Adenosine 50-59 interleukin 1 beta Rattus norvegicus 117-125 17918246-8 2008 A dose-dependent increase in vascular endothelial growth factor-alpha (VEGF-alpha) and interleukin-1beta (IL-1beta) by neutrophils incubated in the presence of oleic and linoleic acid was observed. oleic 160-165 interleukin 1 beta Rattus norvegicus 87-104 17891165-7 2008 Treatment with DF2162 (15 mg kg(-1), twice daily) or metabolite 1, but not metabolite 2, starting on day 10 after arthritis induction diminished histological score, the increase in paw volume, neutrophil influx and local production of TNF, IL-1beta, CCL2 and CCL5. 4-(2-amino-1-methyl-2-oxoethyl)phenyl trifluoromethanesulfonate 15-21 interleukin 1 beta Rattus norvegicus 240-248 17918246-8 2008 A dose-dependent increase in vascular endothelial growth factor-alpha (VEGF-alpha) and interleukin-1beta (IL-1beta) by neutrophils incubated in the presence of oleic and linoleic acid was observed. oleic 160-165 interleukin 1 beta Rattus norvegicus 106-114 17918246-8 2008 A dose-dependent increase in vascular endothelial growth factor-alpha (VEGF-alpha) and interleukin-1beta (IL-1beta) by neutrophils incubated in the presence of oleic and linoleic acid was observed. Linoleic Acid 170-183 interleukin 1 beta Rattus norvegicus 87-104 17918246-8 2008 A dose-dependent increase in vascular endothelial growth factor-alpha (VEGF-alpha) and interleukin-1beta (IL-1beta) by neutrophils incubated in the presence of oleic and linoleic acid was observed. Linoleic Acid 170-183 interleukin 1 beta Rattus norvegicus 106-114 18369576-3 2008 RESULTS: TNF-alpha and IL-1beta secretion and nitric oxide (NO) formation following LPS stimulation were inhibited by treatment with surfactants or DPPC. 1,2-Dipalmitoylphosphatidylcholine 148-152 interleukin 1 beta Rattus norvegicus 23-31 18328572-8 2008 Interestingly, the ERbeta agonist, DPN significantly decreased IL-1beta following LPS treatment in young adult-derived microglia. NAD 35-38 interleukin 1 beta Rattus norvegicus 63-71 18206168-11 2008 The elevated expression of inducible nitric oxide synthase and interleukin-1beta in cyclophosphamide induced cystitis was significantly down-regulated by exogenously applied bilirubin. Cyclophosphamide 84-100 interleukin 1 beta Rattus norvegicus 63-80 18206168-11 2008 The elevated expression of inducible nitric oxide synthase and interleukin-1beta in cyclophosphamide induced cystitis was significantly down-regulated by exogenously applied bilirubin. Bilirubin 174-183 interleukin 1 beta Rattus norvegicus 63-80 18078833-5 2008 Edaravone decreased the expression of iNOS mRNA and its protein stimulated by IL-1beta, resulting in the reduction of NO production. Edaravone 0-9 interleukin 1 beta Rattus norvegicus 78-86 18293166-7 2008 Meanwhile, GW0742 pretreatment exerted inhibition on mRNA expression augmentation of such cytokines as MMP9, MMP2, and IL-1beta in hypertrophic myocytes. GW0742 11-17 interleukin 1 beta Rattus norvegicus 119-127 18374092-11 2008 Interleukin-1beta expression by macrophages was observed during coculture with islets microencapsulated with Biodritin-CaCl2, but not with Biodritin-BaCl2. Calcium Chloride 119-124 interleukin 1 beta Rattus norvegicus 0-17 18304357-0 2008 Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson"s disease. Dopamine 67-75 interleukin 1 beta Rattus norvegicus 30-38 18001810-7 2008 Curcumin also inhibited the release of macrophage inflammatory protein-2 (MIP-2) from RLE cells as observed upon treatment with interleukin-1 beta (IL-1beta) and tumour necrosis factor-alpha (TNFalpha). Curcumin 0-8 interleukin 1 beta Rattus norvegicus 128-146 18001810-7 2008 Curcumin also inhibited the release of macrophage inflammatory protein-2 (MIP-2) from RLE cells as observed upon treatment with interleukin-1 beta (IL-1beta) and tumour necrosis factor-alpha (TNFalpha). Curcumin 0-8 interleukin 1 beta Rattus norvegicus 148-156 18161853-6 2008 Additionally, the inflammatory responses were also reduced in the PBN-treated brain, as indicated by the decreased number of activated microglia following LPS exposure and by the consequently decreased elevation of interleukin1-beta and tumor necrosis factor-alpha contents in the rat brain. phenyl-N-tert-butylnitrone 66-69 interleukin 1 beta Rattus norvegicus 215-264 24692783-8 2008 Compared with the saline group, IL-1beta concentration decreased signifcantly in the OMF, EM-2, and EM-1 groups at 12 hours (P < 0.05, P < 0.05, and P < 0.01, respectively) and at 24 hours (P < 0.05, P < 0.01, and P < 0.01, respectively). Sodium Chloride 18-24 interleukin 1 beta Rattus norvegicus 32-40 18046513-9 2008 We propose that testosterone delays ulcer healing via a fall in blood flow at the ulcer margin, a rise in plasma levels of IL-1 beta and TNF-alpha and, in the case of gastric ulcers, an increase in gastric acid secretion. Testosterone 16-28 interleukin 1 beta Rattus norvegicus 123-132 18357892-0 2008 [Effect of berberine hydrochloride on the expression of interleukin-1beta and tumor necrosis factor-alpha in periodontal tissues in rats]. berberine chloride 11-34 interleukin 1 beta Rattus norvegicus 56-73 18357892-1 2008 OBJECTIVE: To determine the effects of berberine hydrochloride on the expressions of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in periodontal tissues in rat periodontitis model. berberine chloride 39-62 interleukin 1 beta Rattus norvegicus 85-102 18357892-1 2008 OBJECTIVE: To determine the effects of berberine hydrochloride on the expressions of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in periodontal tissues in rat periodontitis model. berberine chloride 39-62 interleukin 1 beta Rattus norvegicus 104-112 18357892-6 2008 Treatment with berberine hydrochloride decreased the levels of IL-1beta and TNF-alpha in periodontitis tissues (P<0.05). berberine chloride 15-38 interleukin 1 beta Rattus norvegicus 63-71 18357892-8 2008 CONCLUSION: Berberine hydrochloride inhibited the expression of IL-1beta and TNF-alpha in periodontal tissues in rats periodontitis model and promoted the regeneration of the periodontal tissues. berberine chloride 12-35 interleukin 1 beta Rattus norvegicus 64-72 18222977-5 2008 We observed at D4 that MTX induced mucosal damage and increased intestinal permeability (7-fold) and the mucosal concentration of interleukin (IL)-1beta and IL-6 (4- to 6-fold). Methotrexate 23-26 interleukin 1 beta Rattus norvegicus 130-152 17874178-2 2008 IL-1beta induced a dose-dependent neutrophil migration to the peritoneal cavity of rats which depends on LTB(4), PAF and cytokines, since the animal treatment with inhibitors of these mediators (MK 886, PCA 4248 and dexamethasone respectively) inhibited IL-1beta-induced neutrophil migration. Dexamethasone 216-229 interleukin 1 beta Rattus norvegicus 0-8 17874178-5 2008 The chemotactic activity of the supernatant of IL-1beta-stimulated macrophages is due to the presence of LTB(4), since MK 886 inhibited its release. MK-886 119-125 interleukin 1 beta Rattus norvegicus 47-55 17693925-13 2008 The heatstroke-induced increased levels of IL-1beta and TNF-alpha in the hypothalamus were suppressed by L-arginine treatment. Arginine 105-115 interleukin 1 beta Rattus norvegicus 43-51 17936043-6 2008 Pretreatment of cells with rebamipide resulted in up-regulation of iNOS induction by IL-1beta, followed by increased NO production. rebamipide 27-37 interleukin 1 beta Rattus norvegicus 85-93 18096265-3 2008 METHODS: NHE inhibitor (FR183998) was administered to rats treated with d-galactosamine/lipopolysaccharide (GalN/LPS), or incubated with cultured hepatocytes stimulated by pro-inflammatory cytokine, interleukin (IL)-1beta. FR 183998 24-32 interleukin 1 beta Rattus norvegicus 199-221 17920124-8 2008 Moreover, the rIL-1beta-induced IL-1beta and COX-2 expression were reduced by p38 MAPK inhibitor (SB203580) and JNK inhibitor (SP600125), respectively. SB 203580 98-106 interleukin 1 beta Rattus norvegicus 14-23 17920124-8 2008 Moreover, the rIL-1beta-induced IL-1beta and COX-2 expression were reduced by p38 MAPK inhibitor (SB203580) and JNK inhibitor (SP600125), respectively. pyrazolanthrone 127-135 interleukin 1 beta Rattus norvegicus 14-23 18053651-8 2008 Either indomethacin or an EP1 receptor antagonist suppressed the increased [Ca(2+)]i response to BK invoked by treatment with IL-1beta. Indomethacin 7-19 interleukin 1 beta Rattus norvegicus 126-134 17981803-5 2008 Treatment of rats with atorvastatin increased IL-4 concentration in hippocampal tissue prepared from LPS-treated and aged rats and abrogated the age-related and LPS-induced increases in pro-inflammatory cytokines, interferon-gamma (IFNgamma) and IL-1beta, and the accompanying deficit in LTP. Atorvastatin 23-35 interleukin 1 beta Rattus norvegicus 246-254 18053651-9 2008 IL-1beta treatment increased BK-induced PGE(2) release from cultured myenteric plexus cells. Prostaglandins E 40-43 interleukin 1 beta Rattus norvegicus 0-8 18053651-10 2008 These results suggest that IL-1beta promotes up-regulation of B1R expression in glial cells, resulting in the potentiation of neural responses to BK through the elevation of PGE(2) released from glial cells. Prostaglandins E 174-177 interleukin 1 beta Rattus norvegicus 27-35 17962358-10 2008 PDGF-BB, IL-1beta, and angiotensin II induced ROS production, which was abolished by DPI and apocynin. Reactive Oxygen Species 46-49 interleukin 1 beta Rattus norvegicus 9-17 17962358-10 2008 PDGF-BB, IL-1beta, and angiotensin II induced ROS production, which was abolished by DPI and apocynin. diphenyleneiodonium 85-88 interleukin 1 beta Rattus norvegicus 9-17 17962358-11 2008 DPI inhibited PDGF-induced proliferation, IL-1beta-induced chemokine production, and expression of alpha-smooth muscle actin and collagen. diphenyleneiodonium 0-3 interleukin 1 beta Rattus norvegicus 42-50 18047633-12 2008 Levels of IL-1beta, IL-6 and AngII were all significantly increased (P < 0.05) in the sodium-loaded rats. Sodium 89-95 interleukin 1 beta Rattus norvegicus 10-18 18199331-10 2008 At these doses, thiazolidinediones reduced synovitis and synovial expression of TNF-alpha, IL-1beta and basic fibroblast growth factor without affecting neovascularization or the expression of vascular endothelial growth factor. Thiazolidinediones 16-34 interleukin 1 beta Rattus norvegicus 91-99 17991694-7 2008 Suppressed responsiveness of the CRH neurones, and hence the HPA axis, following IL-1beta in late pregnancy is explained by presynaptic inhibition of noradrenaline release in the pPVN, due to increased endogenous enkephalin and mu-opioid receptor production in brainstem NTS neurones. Norepinephrine 150-163 interleukin 1 beta Rattus norvegicus 81-89 17717418-8 2008 RESULTS: Inhalation of isoflurane after induction of endotoxemia attenuated the release of TNF-alpha (-52%, p < 0.05) and IL-1 beta (-39%, p < 0.05) as compared to the LPS group, while IL-6 and IL-10 levels were not significantly altered. Isoflurane 23-33 interleukin 1 beta Rattus norvegicus 125-134 18037506-5 2008 We identified an increased expression of interleukin 1beta and glial cell line-derived neurotrophic factor in DA rats as the possible mechanism of the observed endogenous neuroprotection in MOG-induced optic neuritis. da 110-112 interleukin 1 beta Rattus norvegicus 41-58 18035585-3 2008 We previously showed that cerulein induced IL-1beta expression through the Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3 pathway in pancreatic acinar cells. Ceruletide 26-34 interleukin 1 beta Rattus norvegicus 43-51 18679050-2 2008 We investigated the GABA-mediated suppression of the synergistic release of interleukin (IL)-6 due to interleukin 1-beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha). gamma-Aminobutyric Acid 20-24 interleukin 1 beta Rattus norvegicus 102-120 18483565-4 2008 In this work, we investigated the effect of NAC administration on cortical expressions of nuclear factor kappa B (NF-kappaB) and inflammatory proteins such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and intercellular adhesion molecule-1 (ICAM-1) after TBI. Acetylcysteine 44-47 interleukin 1 beta Rattus norvegicus 159-176 18483565-6 2008 In animals given NAC post-TBI, NF-kappaB, IL-1beta, TNF-alpha, and ICAM-1 were decreased in comparison to vehicle-treated animals. Acetylcysteine 17-20 interleukin 1 beta Rattus norvegicus 42-50 17939964-5 2008 Urokinase plasminogen activator (uPA) was constitutively expressed on neuronal membrane fractions, and amiloride (an antagonist of uPA) or plasminogen activator inhibitor (PAI)-1 significantly reduced IL-1beta-induced neurotoxicity. Amiloride 103-112 interleukin 1 beta Rattus norvegicus 201-209 17920716-0 2008 Different response between production of free radicals induced by central and peripheral administration of interleukin-1beta in conscious rats. Free Radicals 41-54 interleukin 1 beta Rattus norvegicus 107-124 17920716-1 2008 We examined whether central or peripheral administration of interleukin-1beta (IL-1beta) might change levels of nitric oxide (NO) and hydroxyl radical (*OH) in the medial prefrontal cortex (mPFC). Nitric Oxide 112-124 interleukin 1 beta Rattus norvegicus 60-77 17920716-1 2008 We examined whether central or peripheral administration of interleukin-1beta (IL-1beta) might change levels of nitric oxide (NO) and hydroxyl radical (*OH) in the medial prefrontal cortex (mPFC). Nitric Oxide 112-124 interleukin 1 beta Rattus norvegicus 79-87 17920716-1 2008 We examined whether central or peripheral administration of interleukin-1beta (IL-1beta) might change levels of nitric oxide (NO) and hydroxyl radical (*OH) in the medial prefrontal cortex (mPFC). Hydroxyl Radical 134-150 interleukin 1 beta Rattus norvegicus 60-77 17920716-1 2008 We examined whether central or peripheral administration of interleukin-1beta (IL-1beta) might change levels of nitric oxide (NO) and hydroxyl radical (*OH) in the medial prefrontal cortex (mPFC). Hydroxyl Radical 134-150 interleukin 1 beta Rattus norvegicus 79-87 18155487-5 2008 In the VIT-treated group, the number of interleukin-1 beta (IL-1 beta)-expressing macrophages initially increased, followed by that of transforming growth factor-beta1 (TGF-beta1)-expressing macrophages. calcium hydroxide, iodoform, silicone oil drug combination 7-10 interleukin 1 beta Rattus norvegicus 40-58 18155487-5 2008 In the VIT-treated group, the number of interleukin-1 beta (IL-1 beta)-expressing macrophages initially increased, followed by that of transforming growth factor-beta1 (TGF-beta1)-expressing macrophages. calcium hydroxide, iodoform, silicone oil drug combination 7-10 interleukin 1 beta Rattus norvegicus 60-69 18679050-2 2008 We investigated the GABA-mediated suppression of the synergistic release of interleukin (IL)-6 due to interleukin 1-beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha). gamma-Aminobutyric Acid 20-24 interleukin 1 beta Rattus norvegicus 122-131 17920716-3 2008 In the mPFC, central administration of IL-1beta into the mPFC resulted in dose-dependent increases in levels of both NOx(-) and 2,3-DHBA. nicotine 1-N-oxide 117-121 interleukin 1 beta Rattus norvegicus 39-47 18679050-8 2008 Western blot analysis revealed that co-treatments with IL-1 beta and TNF-alpha resulted in an increase in intracellular IL-6 that was prevented by GABA. gamma-Aminobutyric Acid 147-151 interleukin 1 beta Rattus norvegicus 55-64 17920716-3 2008 In the mPFC, central administration of IL-1beta into the mPFC resulted in dose-dependent increases in levels of both NOx(-) and 2,3-DHBA. 2,3-dihydroxybenzoic acid 128-136 interleukin 1 beta Rattus norvegicus 39-47 17920716-4 2008 In contrast, peripheral administration of IL-1beta significantly increased NOx(-) levels but not 2,3-DHBA levels. nicotine 1-N-oxide 75-78 interleukin 1 beta Rattus norvegicus 42-50 17920716-5 2008 Perfusion of Mn(III) tetrakis (4-benzoic acid) porphyrin chloride, a superoxide (O(2)(-)) dismutase mimic, into the mPFC reduced the increases in levels of 2,3-DHBA induced by centrally administered IL-1beta, but enhanced the increases in levels of NOx(-) induced by centrally administered IL-1beta. mn(iii) tetrakis (4-benzoic acid) porphyrin chloride 13-65 interleukin 1 beta Rattus norvegicus 199-207 17920716-5 2008 Perfusion of Mn(III) tetrakis (4-benzoic acid) porphyrin chloride, a superoxide (O(2)(-)) dismutase mimic, into the mPFC reduced the increases in levels of 2,3-DHBA induced by centrally administered IL-1beta, but enhanced the increases in levels of NOx(-) induced by centrally administered IL-1beta. mn(iii) tetrakis (4-benzoic acid) porphyrin chloride 13-65 interleukin 1 beta Rattus norvegicus 290-298 17920716-5 2008 Perfusion of Mn(III) tetrakis (4-benzoic acid) porphyrin chloride, a superoxide (O(2)(-)) dismutase mimic, into the mPFC reduced the increases in levels of 2,3-DHBA induced by centrally administered IL-1beta, but enhanced the increases in levels of NOx(-) induced by centrally administered IL-1beta. 2,3-dihydroxybenzoic acid 156-164 interleukin 1 beta Rattus norvegicus 199-207 17920716-5 2008 Perfusion of Mn(III) tetrakis (4-benzoic acid) porphyrin chloride, a superoxide (O(2)(-)) dismutase mimic, into the mPFC reduced the increases in levels of 2,3-DHBA induced by centrally administered IL-1beta, but enhanced the increases in levels of NOx(-) induced by centrally administered IL-1beta. 2,3-dihydroxybenzoic acid 156-164 interleukin 1 beta Rattus norvegicus 290-298 17920716-7 2008 This finding should be useful for our understanding of the response of NO and free radicals such as *OH and O(2)(-) in the mPFC after central and peripheral administration of IL-1beta. Free Radicals 78-91 interleukin 1 beta Rattus norvegicus 175-183 17920716-7 2008 This finding should be useful for our understanding of the response of NO and free radicals such as *OH and O(2)(-) in the mPFC after central and peripheral administration of IL-1beta. Superoxides 108-113 interleukin 1 beta Rattus norvegicus 175-183 17926059-11 2007 The radioimmunoassay result showed that the blood IL-1beta level was increased after the intraperitoneal injection of rmIL-1beta (750 ng/kg) from 0.48+/-0.08 to 0.78+/-0.07 ng/ml (P<0.05). rmil-1beta 118-128 interleukin 1 beta Rattus norvegicus 50-58 18751923-5 2008 This phenomenon is referred to as IL-1b hyperresponsiveness and is linked to abnormal regulation of various acute phase proteins during aging.Evidence has consistently indicated that activation of neutral sphingomyelinase and the resulting accumulation of ceramide mediate cellular responses to LPS, IL-1beta, and TNFalpha in young animals. Ceramides 256-264 interleukin 1 beta Rattus norvegicus 34-39 18751923-5 2008 This phenomenon is referred to as IL-1b hyperresponsiveness and is linked to abnormal regulation of various acute phase proteins during aging.Evidence has consistently indicated that activation of neutral sphingomyelinase and the resulting accumulation of ceramide mediate cellular responses to LPS, IL-1beta, and TNFalpha in young animals. Ceramides 256-264 interleukin 1 beta Rattus norvegicus 300-308 17904177-8 2008 In summary, the present study indicates that the high level of IL-6 observed in the rat peritoneal cavity after ip CCl(4) administration is at least partially produced by PMCs stimulated cooperatively with IL-1alpha, IL-1beta, TNF-alpha and PGE(2). Cefaclor 115-118 interleukin 1 beta Rattus norvegicus 217-225 18035502-0 2007 Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus. Prostaglandins 0-14 interleukin 1 beta Rattus norvegicus 97-115 18035502-2 2007 There is evidence suggesting that the induction of prostaglandin (PG) formation by IL-1beta is involved in impairments in working and spatial memory following IL-1beta. Prostaglandins 51-64 interleukin 1 beta Rattus norvegicus 83-91 18035502-2 2007 There is evidence suggesting that the induction of prostaglandin (PG) formation by IL-1beta is involved in impairments in working and spatial memory following IL-1beta. Prostaglandins 51-64 interleukin 1 beta Rattus norvegicus 159-167 18035502-2 2007 There is evidence suggesting that the induction of prostaglandin (PG) formation by IL-1beta is involved in impairments in working and spatial memory following IL-1beta. Prostaglandins 66-68 interleukin 1 beta Rattus norvegicus 83-91 18035502-2 2007 There is evidence suggesting that the induction of prostaglandin (PG) formation by IL-1beta is involved in impairments in working and spatial memory following IL-1beta. Prostaglandins 66-68 interleukin 1 beta Rattus norvegicus 159-167 18035502-3 2007 The present experiments extend these findings by showing that PGs are responsible for memory deficits in contextual fear conditioning that occur following IL-1beta injection into the dorsal hippocampus of Sprague-Dawley rats. Phosphatidylglycerols 62-65 interleukin 1 beta Rattus norvegicus 155-163 18035502-4 2007 Cyclooxygenase (COX) inhibition blocked the disruption in contextual fear conditioning produced by IL-1beta and COX inhibition alone also disrupted contextual memory, suggesting an inverted U-shaped relationship between PG levels and memory. Prostaglandins 220-222 interleukin 1 beta Rattus norvegicus 99-107 18025227-5 2007 Selectively blocking p38 by pretreatment with SB 239063, a potent and selective p38 inhibitor, suppressed the stress-promoted TNF-alpha, IL-1beta, and CINC-1 production and then prevented the subsequent neutrophil infiltration, gastric mucosal epithelial necrosis and apoptosis, and the ulcerative lesions formation. SB 239063 46-55 interleukin 1 beta Rattus norvegicus 137-145 17992263-6 2007 Exogenous rIL-1beta recapitulated a high degree of bleomycin-induced lung pathology, and specific blockade of IL-1R1 by IL-1 receptor antagonist dramatically reduced bleomycin-induced inflammation. Bleomycin 51-60 interleukin 1 beta Rattus norvegicus 10-19 17607157-10 2007 Incubation of naive bronchial segments with IL-1beta, but not with IL-10 or TNF-alpha, significantly induced BHR that was prevented by N-L-nitroarginine methyl ester. n-l-nitroarginine methyl ester 135-165 interleukin 1 beta Rattus norvegicus 44-52 17935147-5 2007 The anti-inflammatory effects of alcohol were confirmed by decreased expression of pro-inflammatory cytokines including TNFalpha, IL-1beta, IL-18, TGFbeta, and MCP-1. Alcohols 33-40 interleukin 1 beta Rattus norvegicus 130-138 18030068-13 2007 Parecoxib treatment was associated with lower apoptotic rates (1.0 +/- 0.2 vs. 4.0 +/- 0.4%, P < 0.001) and preservation of arteriolar density (20 +/- 5 vs. 8 +/- 2 mm/mm3, P = 0.018) in the peri-infarct area, without differences in circulating interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, and interferon-gamma levels. parecoxib 0-9 interleukin 1 beta Rattus norvegicus 248-265 17991490-9 2007 Benzo(a)pyrene also induced TNF-alpha and IL-1beta production in PMNs, which was significantly reversed by genistein. Benzo(a)pyrene 0-14 interleukin 1 beta Rattus norvegicus 42-50 17991490-9 2007 Benzo(a)pyrene also induced TNF-alpha and IL-1beta production in PMNs, which was significantly reversed by genistein. Genistein 107-116 interleukin 1 beta Rattus norvegicus 42-50 18001276-5 2007 Here we analysed cells positive for 5-bromo-2-deoxyuridine (BrdU; 50 mg/kg) in animals in which cleavage of IL-1beta was inhibited by the caspase-1 inhibitor Ac-YVAD-CMK (10 pmol). Bromodeoxyuridine 36-58 interleukin 1 beta Rattus norvegicus 108-116 18001276-5 2007 Here we analysed cells positive for 5-bromo-2-deoxyuridine (BrdU; 50 mg/kg) in animals in which cleavage of IL-1beta was inhibited by the caspase-1 inhibitor Ac-YVAD-CMK (10 pmol). Bromodeoxyuridine 60-64 interleukin 1 beta Rattus norvegicus 108-116 18001276-5 2007 Here we analysed cells positive for 5-bromo-2-deoxyuridine (BrdU; 50 mg/kg) in animals in which cleavage of IL-1beta was inhibited by the caspase-1 inhibitor Ac-YVAD-CMK (10 pmol). N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone 158-169 interleukin 1 beta Rattus norvegicus 108-116 18045488-7 2007 RESULTS: Fenofibrate administration significantly reduced serum total bilirubin, AST, ALT, ALP, and GGT, TNF-alpha, IL-1 beta levels, and TBA (P < 0.01). Fenofibrate 9-20 interleukin 1 beta Rattus norvegicus 116-125 17962483-5 2007 RESULTS: Isoproterenol treatment significantly decreased protein levels of iNOS, TNF-alpha, and IL-1B, in rMC-1 cells cultured in high glucose as early as 1 hour, compared with cells receiving no treatment. Isoproterenol 9-22 interleukin 1 beta Rattus norvegicus 96-101 17962483-9 2007 Isoproterenol significantly increased gene expression for IL-1B after 24 hours of treatment. Isoproterenol 0-13 interleukin 1 beta Rattus norvegicus 58-63 17962483-10 2007 CONCLUSIONS: These results suggest that stimulation of beta-adrenergic receptors with isoproterenol leads to decreased levels of PGE(2), TNF-alpha, and IL-1B protein content, and in both gene expression and protein levels of iNOS in Muller cells cultured in hyperglycemia. Isoproterenol 86-99 interleukin 1 beta Rattus norvegicus 152-157 18008033-8 2007 RESULTS: In rats treated with APC (50 microg/kg) or CNI1493, the severity of pancreatitis and expression of pancreatic TNF-alpha and IL-1beta proteins were attenuated by the decreased expression and activity of p38 MAPK and JNK (vs. the SAP group, P < 0.01). BENSULIDE 237-240 interleukin 1 beta Rattus norvegicus 133-141 17997947-6 2007 The content of TNF-alpha and IL-1beta at each phase point after ischemia-reperfusion in SA-treated was decreased as compared with that in the untreated group, and there were differences between SA-treated group and untreated group at 72 h after ischemia-reperfusion (P<0.01). sa 88-90 interleukin 1 beta Rattus norvegicus 29-37 17705056-3 2007 RESULTS: Macrophages that were stimulated with PTFE produced significantly more TNF-alpha and IL1-beta than unstimulated macrophages (p < 0.001). Polytetrafluoroethylene 47-51 interleukin 1 beta Rattus norvegicus 94-102 17705056-4 2007 The PLGA, NPG, beta-TCP, and CPC groups also induced moderate TNF-alpha and IL1-beta expression (p < 0.01). beta-tricalcium phosphate 15-23 interleukin 1 beta Rattus norvegicus 76-84 17705056-4 2007 The PLGA, NPG, beta-TCP, and CPC groups also induced moderate TNF-alpha and IL1-beta expression (p < 0.01). cytidylyl-(3'-5')-cytidine 29-32 interleukin 1 beta Rattus norvegicus 76-84 18090225-5 2007 Quercetin, apigenin, and luteolin completely protected against IL-1beta- and IFN-gamma-mediated cytotoxicity in RIN cells. Quercetin 0-9 interleukin 1 beta Rattus norvegicus 63-71 18090225-6 2007 Incubation with quercetin, apigenin, and luteolin resulted in a significant reduction in IL-1beta- and IFN-gamma-induced nitric oxide production, a finding that correlated well with reduced levels of the inducible form of NO synthase messenger RNA and protein. Quercetin 16-25 interleukin 1 beta Rattus norvegicus 89-97 18090225-6 2007 Incubation with quercetin, apigenin, and luteolin resulted in a significant reduction in IL-1beta- and IFN-gamma-induced nitric oxide production, a finding that correlated well with reduced levels of the inducible form of NO synthase messenger RNA and protein. Nitric Oxide 121-133 interleukin 1 beta Rattus norvegicus 89-97 18090225-9 2007 Quercetin, apigenin, and luteolin also prevented IL-1beta- and IFN-gamma-mediated inhibition of insulin secretion. Quercetin 0-9 interleukin 1 beta Rattus norvegicus 49-57 18090225-10 2007 CONCLUSION: Quercetin, apigenin, and luteolin inhibited cytotoxicity in RIN cells and attenuated the decrease of glucose-stimulated insulin secretion in islets by IL-1beta and IFN-gamma. Quercetin 12-21 interleukin 1 beta Rattus norvegicus 163-171 18090225-10 2007 CONCLUSION: Quercetin, apigenin, and luteolin inhibited cytotoxicity in RIN cells and attenuated the decrease of glucose-stimulated insulin secretion in islets by IL-1beta and IFN-gamma. Apigenin 23-31 interleukin 1 beta Rattus norvegicus 163-171 18090225-10 2007 CONCLUSION: Quercetin, apigenin, and luteolin inhibited cytotoxicity in RIN cells and attenuated the decrease of glucose-stimulated insulin secretion in islets by IL-1beta and IFN-gamma. Glucose 113-120 interleukin 1 beta Rattus norvegicus 163-171 17698507-9 2007 Pretreatment with either PTX or Etan resulted in the attenuation of liver injury and diminished circulating concentrations of TNF, IL-1beta, IL-6, macrophage inflammatory protein-2, and coagulation/fibrinolysis biomarkers in LPS/RAN-cotreated animals. Pentoxifylline 25-28 interleukin 1 beta Rattus norvegicus 131-139 17693623-6 2007 Inhibition of GSH synthesis in young hepatocytes activates NSMase, causing increased JNK activation and IRAK-1 stabilization in response to IL-1beta, mimicking the hyperresponsiveness typical for aged hepatocytes. Glutathione 14-17 interleukin 1 beta Rattus norvegicus 140-148 17693623-7 2007 Vice versa, increased GSH content in hepatocytes from aged animals by treatment with N-acetylcysteine inhibits NSMase activity and restores normal IL-1beta response. Glutathione 22-25 interleukin 1 beta Rattus norvegicus 147-155 17693623-7 2007 Vice versa, increased GSH content in hepatocytes from aged animals by treatment with N-acetylcysteine inhibits NSMase activity and restores normal IL-1beta response. Acetylcysteine 85-101 interleukin 1 beta Rattus norvegicus 147-155 17693623-9 2007 In summary, this report demonstrates that depletion of cellular GSH during aging plays an important role in regulating the hepatic response to IL-1beta by inducing NSMase-2 activity. Glutathione 64-67 interleukin 1 beta Rattus norvegicus 143-151 17984161-7 2007 The pro-inflammatory cytokines (TNFalpha, IL1beta and IFNgamma), were significantly higher whereas the anti-inflammatory cytokine, IL10 was lower in the stimulated whole blood culture of IFNalpha treated rats. ifnalpha 187-195 interleukin 1 beta Rattus norvegicus 42-49 17984161-8 2007 In the brain, both pro-inflammatory cytokine IL1beta and anti-inflammatory cytokine IL10 were higher in hypothalamus of the IFNalpha treated rats; by contrast the concentration of IL10 was lowest in hippocampus region of this group compared to the other groups. ifnalpha 124-132 interleukin 1 beta Rattus norvegicus 45-52 17706606-7 2007 The pan-selective MMP inhibitor GM 6001 effectively blocked IL-1beta stimulated migration. N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide 32-39 interleukin 1 beta Rattus norvegicus 60-68 18049307-6 2007 Basal, calcium ionophore-stimulated, or interleukin-1 beta-induced NO synthesis was determined by measuring total nitrite in the media. Nitrites 114-121 interleukin 1 beta Rattus norvegicus 40-58 17786293-16 2007 Inhalation of isoflurane significantly attenuated plasma levels of TNFalpha (-65%) and IL-1beta (-53%) compared to the LPS-only group whereas it had no effect on nitrite production from cultured AM. Isoflurane 14-24 interleukin 1 beta Rattus norvegicus 87-95 17938539-11 2007 CONCLUSION: Our results suggest that, under diabetic conditions, the MAP kinase superfamily was activated by different pathways in the vasculature; i.e., ERKs and p38 might be mainly phosphorylated by a complex of high concentrations of glucose and of several types of proinflammatory cytokines, but the phosphorylation of JNK-1 might depend on the concentration of proinflammatory cytokines such as IL-1beta, and/or additional unknown factors, except glucose. Glucose 237-244 interleukin 1 beta Rattus norvegicus 400-408 17436088-8 2007 NPI 32101 treatment suppresses the expression and activity of MMP-9 and the expression of TNF-alpha, IL-1beta, and IL-12, mechanisms by which NPI 32101 may exert its anti-inflammatory effects. npi 32101 0-9 interleukin 1 beta Rattus norvegicus 101-109 17436088-8 2007 NPI 32101 treatment suppresses the expression and activity of MMP-9 and the expression of TNF-alpha, IL-1beta, and IL-12, mechanisms by which NPI 32101 may exert its anti-inflammatory effects. npi 32101 142-151 interleukin 1 beta Rattus norvegicus 101-109 17493833-7 2007 Stimulation of head kidney leukocytes with different concentrations of rIL-1beta (ranging from 0 to 100ng/ml) resulted in a dose-dependent reduction of the Dila-DAB expression. diazobenzenesulfonic acid 161-164 interleukin 1 beta Rattus norvegicus 71-80 17911403-2 2007 Addition of IL-1beta, tumour necrosis factor-alpha and IFN-gamma (at concentrations that did not induce apoptosis) inhibited chronic (24 h) and acute stimulated levels of insulin release (by 59 and 93% respectively), increased cellular glucose and alanine consumption, and also elevated lactate and glutamate release. Glucose 236-243 interleukin 1 beta Rattus norvegicus 12-50 17911403-2 2007 Addition of IL-1beta, tumour necrosis factor-alpha and IFN-gamma (at concentrations that did not induce apoptosis) inhibited chronic (24 h) and acute stimulated levels of insulin release (by 59 and 93% respectively), increased cellular glucose and alanine consumption, and also elevated lactate and glutamate release. Alanine 248-255 interleukin 1 beta Rattus norvegicus 12-50 17911403-2 2007 Addition of IL-1beta, tumour necrosis factor-alpha and IFN-gamma (at concentrations that did not induce apoptosis) inhibited chronic (24 h) and acute stimulated levels of insulin release (by 59 and 93% respectively), increased cellular glucose and alanine consumption, and also elevated lactate and glutamate release. Lactic Acid 287-294 interleukin 1 beta Rattus norvegicus 12-50 17911403-2 2007 Addition of IL-1beta, tumour necrosis factor-alpha and IFN-gamma (at concentrations that did not induce apoptosis) inhibited chronic (24 h) and acute stimulated levels of insulin release (by 59 and 93% respectively), increased cellular glucose and alanine consumption, and also elevated lactate and glutamate release. Glutamic Acid 299-308 interleukin 1 beta Rattus norvegicus 12-50 17760822-7 2007 Significantly lower expression of cyclooxygenase-2 and interleukin-1beta mRNA, but higher interleukin-6 expression, were observed in gingiva from cyclosporine A-treated rats than in those from the control rats. Cyclosporine 146-160 interleukin 1 beta Rattus norvegicus 55-72 18062121-12 2007 Significant reductions in IL-1beta (P < 0.01 ), TNF-alpha (P < 0.05), and osteoclast formation (P < 0.01) occurred in the presence of SD282. indole-5-carboxamide 143-148 interleukin 1 beta Rattus norvegicus 26-34 17895847-9 2007 Ethyl pyruvate treatment significantly decreased serum HMGB1, tumor necrosis factor alpha, IL-1beta, and IL-6 levels and ameliorated extrapancreatic organ dysfunction in rats with SAP. ethyl pyruvate 0-14 interleukin 1 beta Rattus norvegicus 91-99 17621647-5 2007 The data indicate that dexamethasone and vitamin D3 ameliorated the age-related increase in IFNgamma and suggest that IFNgamma may be the trigger leading to microglial activation, since it increases MHCII mRNA and IL-1beta release from cultured glia. Dexamethasone 23-36 interleukin 1 beta Rattus norvegicus 214-222 17621647-5 2007 The data indicate that dexamethasone and vitamin D3 ameliorated the age-related increase in IFNgamma and suggest that IFNgamma may be the trigger leading to microglial activation, since it increases MHCII mRNA and IL-1beta release from cultured glia. Cholecalciferol 41-51 interleukin 1 beta Rattus norvegicus 214-222 17621647-6 2007 In parallel with its ability to decrease microglial activation in vivo, we report that treatment of cultured glia with dexamethasone and vitamin D3 blocked the lipopolysaccharide increased MHCII mRNA and IL-1beta concentration, while the IL-1beta-induced increases in activation of JNK and caspase 3 in cultured neurons were also reversed by treatment with dexamethasone and vitamin D3. Dexamethasone 119-132 interleukin 1 beta Rattus norvegicus 204-212 17621647-6 2007 In parallel with its ability to decrease microglial activation in vivo, we report that treatment of cultured glia with dexamethasone and vitamin D3 blocked the lipopolysaccharide increased MHCII mRNA and IL-1beta concentration, while the IL-1beta-induced increases in activation of JNK and caspase 3 in cultured neurons were also reversed by treatment with dexamethasone and vitamin D3. Dexamethasone 119-132 interleukin 1 beta Rattus norvegicus 238-246 17621647-6 2007 In parallel with its ability to decrease microglial activation in vivo, we report that treatment of cultured glia with dexamethasone and vitamin D3 blocked the lipopolysaccharide increased MHCII mRNA and IL-1beta concentration, while the IL-1beta-induced increases in activation of JNK and caspase 3 in cultured neurons were also reversed by treatment with dexamethasone and vitamin D3. Cholecalciferol 137-147 interleukin 1 beta Rattus norvegicus 204-212 17621647-6 2007 In parallel with its ability to decrease microglial activation in vivo, we report that treatment of cultured glia with dexamethasone and vitamin D3 blocked the lipopolysaccharide increased MHCII mRNA and IL-1beta concentration, while the IL-1beta-induced increases in activation of JNK and caspase 3 in cultured neurons were also reversed by treatment with dexamethasone and vitamin D3. Cholecalciferol 137-147 interleukin 1 beta Rattus norvegicus 238-246 17668873-10 2007 More importantly, inhibition of NSMase activity in hepatocytes from aged rats using either scyphostatin or short interfering ribonucleic acid (siRNA) leads to reversion to the "young" phenotype of IL-1beta response. scyphostatin 91-103 interleukin 1 beta Rattus norvegicus 197-205 17984579-1 2007 FR167653 is a potent inhibitor of p38 MAP Kinase and inhibits TNF-alpha and IL-1beta production in inflammatory cells. FR 167653 0-8 interleukin 1 beta Rattus norvegicus 76-84 17645865-3 2007 Employment of c-Jun N-terminal kinase (JNK) inhibitor SP600125 resulted in 3-fold reduction of IGFBP-1 mRNA and protein levels, indicating that IL-1beta-induced IGFBP-1 production is mediated through JNK activation. pyrazolanthrone 54-62 interleukin 1 beta Rattus norvegicus 144-152 18051719-1 2007 OBJECTIVE: To detect the nitric oxide (NO) production and energy metabolism of the interleukin (IL)-1beta-treated residual hepatocytes from rats after partial hepatectomy. Nitric Oxide 25-37 interleukin 1 beta Rattus norvegicus 83-105 18051719-9 2007 IL-1beta decreased the content of ATP and the KBR in the hepatocytes of both groups, and the decrease magni tude in the PH group was significantly larger than that in the Sham group. Adenosine Triphosphate 34-37 interleukin 1 beta Rattus norvegicus 0-8 18051719-9 2007 IL-1beta decreased the content of ATP and the KBR in the hepatocytes of both groups, and the decrease magni tude in the PH group was significantly larger than that in the Sham group. magni tude 102-112 interleukin 1 beta Rattus norvegicus 0-8 18051719-12 2007 CONCLUSION: After partial hepatectomy, increased NO production in the hepatocytes after the treatment of interleukin-1beta may disturb the function of mitochondria by inhibiting the synthesis of ATP. Adenosine Triphosphate 195-198 interleukin 1 beta Rattus norvegicus 105-122 17645865-6 2007 Moreover, glutathione depletion in hepatocytes from young rats potently activated JNK, as well as increased IL-1beta-induced IGFBP-1 mRNA levels, suggesting that age-related oxidative stress underlies the upregulated JNK activation and IGFBP-1 expression. Glutathione 10-21 interleukin 1 beta Rattus norvegicus 108-116 17634417-8 2007 Estradiol also caused an increased release of IL-1beta and TNF-alpha by BAL cells. Estradiol 0-9 interleukin 1 beta Rattus norvegicus 46-54 17543500-5 2007 In contrast to the mechanism described for the rat gene our results indicate that IL-1beta suppresses the IL-6-induced activation of the human gamma-fibrinogen gene particularly by blocking the late phase STAT3-tyrosine phosphorylation NF-kappaB-dependently but independent from de novo protein synthesis. Tyrosine 211-219 interleukin 1 beta Rattus norvegicus 82-90 17687726-7 2007 Pretreatment of cells with NAC or R6G also inhibited silica-induced production of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha, but the inhibition of these cytokines with agents known to block their secretion did not protect cells from silica-induced apoptosis. Acetylcysteine 27-30 interleukin 1 beta Rattus norvegicus 82-104 17367747-5 2007 More specifically, Tacrolimus suppressed the expression of serum interleukin (IL-1beta), tumour necrosis factor (TNF-alpha), IL-6, airpouch exudate PGE(2) and leukocytosis usually observed after the induction of periodontitis. Tacrolimus 19-29 interleukin 1 beta Rattus norvegicus 78-86 17805009-6 2007 The secretion of tumor necrosis factor-alpha (TNF-alpha) and IL-1beta elicited by UCB in astrocytes was reduced in the presence of GUDCA and IL-10, whereas the suppression of IL-6 was only counteracted by GUDCA. glycoursodeoxycholic acid 131-136 interleukin 1 beta Rattus norvegicus 61-69 17805009-6 2007 The secretion of tumor necrosis factor-alpha (TNF-alpha) and IL-1beta elicited by UCB in astrocytes was reduced in the presence of GUDCA and IL-10, whereas the suppression of IL-6 was only counteracted by GUDCA. glycoursodeoxycholic acid 205-210 interleukin 1 beta Rattus norvegicus 61-69 17805009-9 2007 Moreover, GUDCA inhibited TNF-alpha- and IL-1beta-converting enzymes, preventing the maturation of these cytokines and their consequent release. glycoursodeoxycholic acid 10-15 interleukin 1 beta Rattus norvegicus 41-49 17687726-9 2007 The secretion of IL-1beta and TNF-alpha by silica-exposed AM was markedly inhibited by NAC and R6G, suggesting that the production of these cytokines is also ROS dependent. Reactive Oxygen Species 158-161 interleukin 1 beta Rattus norvegicus 17-25 17367747-6 2007 Tacrolimus treatment in periodontitis-induced rats conferred protection against the inflammation-induced tissue and bone loss associated with periodontitis, through a mechanism involving IL-1beta, TNF-alpha and IL-6. Tacrolimus 0-10 interleukin 1 beta Rattus norvegicus 187-195 17900404-5 2007 Following TBI, glutamine supplementation was found to: decrease intestinal concentrations of interleukin (IL) -1beta, tumour necrosis factor-alpha (TNF-alpha) and IL-6; downregulate intercellular adhesion molecule-1 (ICAM-1) expression; attenuate TBI-induced damage to the intestine structure; and reduce apoptosis. Glutamine 15-24 interleukin 1 beta Rattus norvegicus 93-116 17895588-6 2007 Furthermore, analysis of inflammatory cytokines in ischemic brain showed that GZFLC treatment significantly down-regulated expressions of pro-inflammatory cytokines including interleukin (IL)-1beta and tissue necrosis factor-alpha and markedly up-regulated expressions of anti-inflammatory cytokines IL-10 and IL-10R both in mRNA and protein levels. gzflc 78-83 interleukin 1 beta Rattus norvegicus 175-197 17687726-7 2007 Pretreatment of cells with NAC or R6G also inhibited silica-induced production of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha, but the inhibition of these cytokines with agents known to block their secretion did not protect cells from silica-induced apoptosis. Silicon Dioxide 53-59 interleukin 1 beta Rattus norvegicus 82-104 17687726-9 2007 The secretion of IL-1beta and TNF-alpha by silica-exposed AM was markedly inhibited by NAC and R6G, suggesting that the production of these cytokines is also ROS dependent. Silicon Dioxide 43-49 interleukin 1 beta Rattus norvegicus 17-25 17687726-9 2007 The secretion of IL-1beta and TNF-alpha by silica-exposed AM was markedly inhibited by NAC and R6G, suggesting that the production of these cytokines is also ROS dependent. Acetylcysteine 87-90 interleukin 1 beta Rattus norvegicus 17-25 17559833-5 2007 Systemic treatment with alpha-humulene largely prevented both tumor necrosis factor-alpha (TNFalpha) and interleukin-1beta (IL-1beta) generation in carrageenan-injected rats, whereas (-)-trans-caryophyllene diminished only TNFalpha release. humulene 24-38 interleukin 1 beta Rattus norvegicus 105-122 17914162-6 2007 IL-1beta-induced beta cell destruction may be mediated by the generation of NO and/or ROS, although the relative importance of NO and ROS in this process remains unclear. ros 86-89 interleukin 1 beta Rattus norvegicus 0-8 17914162-6 2007 IL-1beta-induced beta cell destruction may be mediated by the generation of NO and/or ROS, although the relative importance of NO and ROS in this process remains unclear. ros 134-137 interleukin 1 beta Rattus norvegicus 0-8 17914162-9 2007 That is, IL-1beta exposure (100 U/ml) induced a time-dependent decrease in rat insulinoma (RIN) cell viability, which coincided with an induction in iNOS expression and nitrite accumulation. Nitrites 169-176 interleukin 1 beta Rattus norvegicus 9-17 17669395-11 2007 Also inflammatory markers were reduced after atorvastatin treatment indexed by reduced mRNA expression of VCAM-1 (-24%), tumor necrosis factor alpha (-59%) and interleukin 1beta (-50%) and reduced ICAM-1 (-81%) and VCAM-1 (-74%) positive staining. Atorvastatin 45-57 interleukin 1 beta Rattus norvegicus 160-177 17559833-5 2007 Systemic treatment with alpha-humulene largely prevented both tumor necrosis factor-alpha (TNFalpha) and interleukin-1beta (IL-1beta) generation in carrageenan-injected rats, whereas (-)-trans-caryophyllene diminished only TNFalpha release. humulene 24-38 interleukin 1 beta Rattus norvegicus 124-132 17559833-5 2007 Systemic treatment with alpha-humulene largely prevented both tumor necrosis factor-alpha (TNFalpha) and interleukin-1beta (IL-1beta) generation in carrageenan-injected rats, whereas (-)-trans-caryophyllene diminished only TNFalpha release. Carrageenan 148-159 interleukin 1 beta Rattus norvegicus 105-122 17559833-5 2007 Systemic treatment with alpha-humulene largely prevented both tumor necrosis factor-alpha (TNFalpha) and interleukin-1beta (IL-1beta) generation in carrageenan-injected rats, whereas (-)-trans-caryophyllene diminished only TNFalpha release. Carrageenan 148-159 interleukin 1 beta Rattus norvegicus 124-132 17600534-5 2007 RESULTS: Rats on the omega-3 FA diet exhibited decreased proinflammatory cytokine gene expression (IL-1beta, TNF-alpha) and enhanced IFN-gamma, CAT and SOD messenger RNA expression compared to rats fed a corn oil diet, supporting a diet-induced modulation of host inflammatory reactions. Fatty Acids, Omega-3 21-31 interleukin 1 beta Rattus norvegicus 99-107 17635397-11 2007 RESULTS: Inhalation of sevoflurane significantly attenuated plasma levels of TNF-alpha (-60%, P < 0.05) and IL-1beta (-68%, P < 0.05) as compared with the LPS-only group. Sevoflurane 23-34 interleukin 1 beta Rattus norvegicus 111-119 17635398-12 2007 RESULTS: Inhalation of isoflurane reduced the release of TNF-alpha (P < 0.05) and IL-1beta (P < 0.05) in plasma and IL-1beta (P < 0.05) in BALF. Isoflurane 23-33 interleukin 1 beta Rattus norvegicus 85-93 17635398-12 2007 RESULTS: Inhalation of isoflurane reduced the release of TNF-alpha (P < 0.05) and IL-1beta (P < 0.05) in plasma and IL-1beta (P < 0.05) in BALF. Isoflurane 23-33 interleukin 1 beta Rattus norvegicus 122-130 17612778-6 2007 Treatment with CsA for either 60 or 120 days was associated with bone resorption, represented by lower bone volume and increased number of osteoclasts; serum BALP, TRAP-5b, IL-1beta, IL-6, and TNF-alpha were also higher in these animals. Cyclosporine 15-18 interleukin 1 beta Rattus norvegicus 173-181 17612778-8 2007 This study shows that conversion from CsA to tacrolimus therapy leads to a reversal of the CsA-induced bone loss, which can probably be mediated by downregulation of IL-1beta, IL-6, and TNF-alpha production. Cyclosporine 38-41 interleukin 1 beta Rattus norvegicus 166-174 17612778-8 2007 This study shows that conversion from CsA to tacrolimus therapy leads to a reversal of the CsA-induced bone loss, which can probably be mediated by downregulation of IL-1beta, IL-6, and TNF-alpha production. Tacrolimus 45-55 interleukin 1 beta Rattus norvegicus 166-174 17612778-8 2007 This study shows that conversion from CsA to tacrolimus therapy leads to a reversal of the CsA-induced bone loss, which can probably be mediated by downregulation of IL-1beta, IL-6, and TNF-alpha production. Cyclosporine 91-94 interleukin 1 beta Rattus norvegicus 166-174 17640624-10 2007 Independent of the heat load, Metyrapone rats showed the same thermophysiological responses and IL-1beta and Hsp70 mRNA expressions when compared with vehicle rats. Metyrapone 30-40 interleukin 1 beta Rattus norvegicus 96-104 17600562-16 2007 Administration of lipopolysaccharide or interleukin-1beta to ovariectomized female rats induces cerebrovascular COX-2 and inducible nitric oxide synthase (iNOS) protein expression and increases prostaglandin E(2) expression. Prostaglandins E 194-209 interleukin 1 beta Rattus norvegicus 40-57 17907382-12 2007 Compared with model group, IL-1beta mRNA expression of the local inflammatory tissues in IND and EA-post-treatment groups was down-regulated, and TNF-alpha mRNA expression in Rofecoxib and two EA groups down-regulated slightly. Indomethacin 89-92 interleukin 1 beta Rattus norvegicus 27-35 17321804-3 2007 We then demonstrated with patch clamping technique that extracellular application of IL-1beta dose-dependently inhibited the outward voltage-dependent and TEA-sensitive potassium currents (I(K)) in the PC12 cells, and pre-incubation with the interleukin-1 receptor antagonist almost completely abolished this inhibitory effect. Potassium 169-178 interleukin 1 beta Rattus norvegicus 85-93 18001575-1 2007 OBJECTIVE: To investigate the effect of cytokine interleukin-1 beta (IL-1 beta) on the glutamine synthetase (GS) in retinal Muller cell under high glucose conditions and its possible mechanism. Glucose 147-154 interleukin 1 beta Rattus norvegicus 49-67 18001575-1 2007 OBJECTIVE: To investigate the effect of cytokine interleukin-1 beta (IL-1 beta) on the glutamine synthetase (GS) in retinal Muller cell under high glucose conditions and its possible mechanism. Glucose 147-154 interleukin 1 beta Rattus norvegicus 69-78 18001575-4 2007 Apoptosis of retinal Muller cells induced by IL-1 beta in the control and experimental groups was analyzed by flow cytometry after Annexin V-fluorescein isothiocyanate/Propidium idoium (Annexin V-FITC/PI) staining. propidium idoium 168-184 interleukin 1 beta Rattus norvegicus 45-54 18001575-5 2007 RESULTS: Under high glucose condition, increase in the expression of c-Jun and IL-1 beta and decrease in the expression of GS could be found by western blot analysis and immunocytochemistry (P < 0.05). Glucose 20-27 interleukin 1 beta Rattus norvegicus 79-88 18001575-6 2007 After being treated by IL-1 beta, the expression of GS was down-regulated significantly and the expression of c-Jun was up-regulated significantly in a dose-dependent manner in these two groups, especially under high glucose condition. Glucose 217-224 interleukin 1 beta Rattus norvegicus 23-32 18001575-9 2007 CONCLUSIONS: In mimicked diabetic condition, IL-1 beta decreases the expression of GS in retinal Muller cells, which may elevate the level of glutamate and cause the damage of the ganglion cells. Glutamic Acid 142-151 interleukin 1 beta Rattus norvegicus 45-54 17602892-7 2007 The maximum phenylephrine-induced contraction was greater in aorta from SHRSP incubated with IL-1beta than control. Phenylephrine 12-25 interleukin 1 beta Rattus norvegicus 93-101 17602892-10 2007 CONCLUSIONS: These novel data suggest that IL-1beta has rapid effects on vascular smooth muscle from hypertensive rats to produce constriction and to enhance phenylephrine-induced constriction. Phenylephrine 158-171 interleukin 1 beta Rattus norvegicus 43-51 17694686-4 2007 administration of IL-1beta activates p38 mitogen-activated protein kinase (MAPK), and leads to induction of inducible nitric oxide synthase (iNOS) and release of nitric oxide (NO), which sensitizes the spinal nociceptors and produces thermal hyperalgesia and allodynia. Nitric Oxide 118-130 interleukin 1 beta Rattus norvegicus 18-26 17471174-6 2007 However, only alpha-humulene significantly reduced the increase in TNF-alpha and IL-1beta levels, paw oedema and the up-regulation of B(1) receptors following treatment with LPS. humulene 14-28 interleukin 1 beta Rattus norvegicus 81-89 17471174-8 2007 CONCLUSIONS AND IMPLICATIONS: Both alpha-humulene and trans-caryophyllene inhibit the LPS-induced NF-kappaB activation and neutrophil migration, although only alpha-humulene had the ability to prevent the production of pro-inflammatory cytokines TNF-alpha and IL-1beta and the in vivo up-regulation of kinin B(1) receptors. humulene 35-49 interleukin 1 beta Rattus norvegicus 260-268 17471174-8 2007 CONCLUSIONS AND IMPLICATIONS: Both alpha-humulene and trans-caryophyllene inhibit the LPS-induced NF-kappaB activation and neutrophil migration, although only alpha-humulene had the ability to prevent the production of pro-inflammatory cytokines TNF-alpha and IL-1beta and the in vivo up-regulation of kinin B(1) receptors. humulene 159-173 interleukin 1 beta Rattus norvegicus 260-268 17901573-10 2007 Enalapril, quinapril and losartan significantly decreased LPS-stimulated TNF-alpha and IL-1 beta level after 21 days. Quinapril 11-20 interleukin 1 beta Rattus norvegicus 87-96 17612572-12 2007 Our results show that pre-administration of lovastatin improved functional outcomes and reduced extent of brain damage, with a concomitant decrease in tissue levels of TNF-alpha and IL-1beta mRNA and protein. Lovastatin 44-54 interleukin 1 beta Rattus norvegicus 182-190 17400913-7 2007 17-AAG treatment significantly suppressed the LPS-induced increase in retinal leukocyte adhesion; vascular leakage; NF-kappaB, HIF-1alpha, p38, and PI-3K activity; and VEGF, TNF-alpha, and IL-1beta levels. tanespimycin 0-6 interleukin 1 beta Rattus norvegicus 189-197 17901573-10 2007 Enalapril, quinapril and losartan significantly decreased LPS-stimulated TNF-alpha and IL-1 beta level after 21 days. Enalapril 0-9 interleukin 1 beta Rattus norvegicus 87-96 17901573-10 2007 Enalapril, quinapril and losartan significantly decreased LPS-stimulated TNF-alpha and IL-1 beta level after 21 days. Losartan 25-33 interleukin 1 beta Rattus norvegicus 87-96 17610583-5 2007 The results from whole-cell patch-clamp recordings and calcium imaging showed that extracellular application of IL-1beta significantly decreased the outward potassium current and triggered a transient rise in [Ca(2+)](i) in the cultured glomus cells of rat CB. Calcium 55-62 interleukin 1 beta Rattus norvegicus 112-120 17452936-12 2007 Bay 11-7082 selectively blocked the stress-induced nuclear factor-kappaB activation and up-regulation of tumor necrosis factor-alpha, interleukin-1beta, CINC-1, ICAM-1, and iNOS messenger RNAs. 3-(4-methylphenylsulfonyl)-2-propenenitrile 0-11 interleukin 1 beta Rattus norvegicus 134-151 17610583-5 2007 The results from whole-cell patch-clamp recordings and calcium imaging showed that extracellular application of IL-1beta significantly decreased the outward potassium current and triggered a transient rise in [Ca(2+)](i) in the cultured glomus cells of rat CB. Potassium 157-166 interleukin 1 beta Rattus norvegicus 112-120 17610583-6 2007 Furthermore, by using extracellular recordings and pharmacological intervention, it was found that IL-1beta stimulation of the CB in the anaesthetized rat in vivo significantly increased the discharge rate in the carotid sinus nerve, most probably mediated by ATP release. Adenosine Triphosphate 260-263 interleukin 1 beta Rattus norvegicus 99-107 17272403-7 2007 SDD treatment of experimental burn attenuated septic challenge-related inflammatory responses and improved myocardial contractile responses, producing cardiac TNF-alpha, IL-1beta, and IL-6 levels, LVP, +dP/dt, and rate of LVP fall (-dP/dt) values that were significantly better (P<0.05) than values measured in burn plus sepsis in the absence of SDD. SDDS 0-3 interleukin 1 beta Rattus norvegicus 170-178 17525204-12 2007 However, nicotine decreased the endotoxin-induced elevation of interleukin (IL)-6, IL-1beta, tumor necrosis factor (TNF)-alpha, cytokine-induced neutrophil chemoattractant (CINC)-1, and monocyte chemotactic protein (MCP)-1, but did not affect IL-10 in the serum and aqueous humor. Nicotine 9-17 interleukin 1 beta Rattus norvegicus 83-91 17578710-5 2007 Homocysteine did not affect basal nitrite accumulation; however, it significantly increased the nitrite accumulation induced by the calcium ionophore A23187 or interleukin-1beta only at 1 mM. Nitrites 96-103 interleukin 1 beta Rattus norvegicus 160-177 17626737-7 2007 Bumetanide (15 mg/kg), a specific Na(+) -K(+) -2Cl(-) cotransporter inhibitor, significantly attenuated the TBI-induced neuronal damage by IL-1beta overexpression. Bumetanide 0-10 interleukin 1 beta Rattus norvegicus 139-147 17234889-8 2007 Furthermore, IL-1beta upregulated inducible nitric oxide (NO) synthase and cyclooxygenase-2 mRNA and protein and thus stimulated NO and PGE(2) productions. Nitric Oxide 44-56 interleukin 1 beta Rattus norvegicus 13-21 17234889-8 2007 Furthermore, IL-1beta upregulated inducible nitric oxide (NO) synthase and cyclooxygenase-2 mRNA and protein and thus stimulated NO and PGE(2) productions. Prostaglandins E 136-139 interleukin 1 beta Rattus norvegicus 13-21 17234889-11 2007 Based on these findings, IL-1beta acts as an anti-proliferative mediator, which acts indirectly through the production of PGE(2) and NO from resident macrophage within ileal smooth muscle tissue. Dinoprostone 122-128 interleukin 1 beta Rattus norvegicus 25-33 17489075-5 2007 Pioglitazone decreased TNF-alpha and IL-1B mRNA expression, blunted aortic wall calcification and prevented fragmentation of elastic fibers. Pioglitazone 0-12 interleukin 1 beta Rattus norvegicus 37-42 17375077-11 2007 Thus sulphasalazine post-treatment reduced the mRNA levels of IL-1 beta/IL-1 ra and MCP-1 to the same extent as alendronate and additionally lowered colonic alkaline phosphatase activity, but failed to affect body weight loss or colonic damage score. Sulfasalazine 5-19 interleukin 1 beta Rattus norvegicus 62-71 17158358-2 2007 In this study we investigated the role of phosphatidylcholine-specific phospholipase C (PC-PLC) in silica-stimulated induction of TNF-alpha and IL-1beta and how PC-PLC activity is regulated by silica in a rat alveolar macrophage model. Phosphatidylcholines 42-61 interleukin 1 beta Rattus norvegicus 144-152 17158358-2 2007 In this study we investigated the role of phosphatidylcholine-specific phospholipase C (PC-PLC) in silica-stimulated induction of TNF-alpha and IL-1beta and how PC-PLC activity is regulated by silica in a rat alveolar macrophage model. Silicon Dioxide 99-105 interleukin 1 beta Rattus norvegicus 144-152 17158358-3 2007 We demonstrated that inhibition of PC-PLC, which was achieved with tricychodecan-9-yl-xanthate (D609), blocked the silica-stimulated induction of TNF-alpha and IL-1beta in alveolar macrophage, suggesting that PC-PLC is involved in the silica-associated inflammatory response. tricychodecan-9-yl-xanthate 67-94 interleukin 1 beta Rattus norvegicus 160-168 17158358-3 2007 We demonstrated that inhibition of PC-PLC, which was achieved with tricychodecan-9-yl-xanthate (D609), blocked the silica-stimulated induction of TNF-alpha and IL-1beta in alveolar macrophage, suggesting that PC-PLC is involved in the silica-associated inflammatory response. tricyclodecane-9-yl-xanthogenate 96-100 interleukin 1 beta Rattus norvegicus 160-168 17158358-3 2007 We demonstrated that inhibition of PC-PLC, which was achieved with tricychodecan-9-yl-xanthate (D609), blocked the silica-stimulated induction of TNF-alpha and IL-1beta in alveolar macrophage, suggesting that PC-PLC is involved in the silica-associated inflammatory response. Silicon Dioxide 115-121 interleukin 1 beta Rattus norvegicus 160-168 17464780-2 2007 Intrathecal IL-1beta did not modify the C reflex integrated activity in either group of animals, while producing increased wind-up in intact and decreased wind-up in propentofylline pre-treated rats. propentofylline 166-181 interleukin 1 beta Rattus norvegicus 12-20 17382409-4 2007 Chronic nicotine increased mechanical hypersensitivity, microglia activation, and the production of IL-1beta, but not the number of immune cells at the site of injury. Nicotine 8-16 interleukin 1 beta Rattus norvegicus 100-108 17384935-1 2007 OBJECTIVE: We set out to investigate whether the nebulized and inhaled specific caspase-1 inhibitor Ac-YVAD-CHO has the potential to attenuate the pulmonary and systemic release of the caspase-1-dependent cytokines interleukin-1 beta (IL-1 beta) and interleukin-18 (IL-18) as well as their downstream enzymes iNOS and COX-2 in rat experimental endotoxaemia. L 709049 100-111 interleukin 1 beta Rattus norvegicus 215-233 17384935-1 2007 OBJECTIVE: We set out to investigate whether the nebulized and inhaled specific caspase-1 inhibitor Ac-YVAD-CHO has the potential to attenuate the pulmonary and systemic release of the caspase-1-dependent cytokines interleukin-1 beta (IL-1 beta) and interleukin-18 (IL-18) as well as their downstream enzymes iNOS and COX-2 in rat experimental endotoxaemia. L 709049 100-111 interleukin 1 beta Rattus norvegicus 235-244 17464780-0 2007 Effects of interleukin-1beta on spinal cord nociceptive transmission in intact and propentofylline-treated rats. propentofylline 83-98 interleukin 1 beta Rattus norvegicus 11-28 17250684-5 2007 We report that the Abeta-induced inhibition of LTP was associated with increases in expression of MHCII, JNK phosphorylation and IL-1beta concentration, and that these changes were attenuated by treatment of rats with IL-4 and minocycline. UNII-042A8N37WH 19-24 interleukin 1 beta Rattus norvegicus 129-137 17250684-5 2007 We report that the Abeta-induced inhibition of LTP was associated with increases in expression of MHCII, JNK phosphorylation and IL-1beta concentration, and that these changes were attenuated by treatment of rats with IL-4 and minocycline. Minocycline 227-238 interleukin 1 beta Rattus norvegicus 129-137 17250684-6 2007 We also report that Abeta-induced increases in expression of MHCII and IL-1beta were similarly attenuated by IL-4 and minocycline in glial cultures prepared from neonatal rats. UNII-042A8N37WH 20-25 interleukin 1 beta Rattus norvegicus 71-79 17510525-8 2007 Furthermore, DP treatment significantly inhibited the induction of proinflammatory factor interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha in the culture medium of LPS-treated NSCs mediated by Bcl-2 modulation. Desipramine 13-15 interleukin 1 beta Rattus norvegicus 90-112 17250684-6 2007 We also report that Abeta-induced increases in expression of MHCII and IL-1beta were similarly attenuated by IL-4 and minocycline in glial cultures prepared from neonatal rats. Minocycline 118-129 interleukin 1 beta Rattus norvegicus 71-79 17437639-9 2007 Curcumin also inhibited diabetes-induced elevation in the levels of IL-1beta, VEGF and NF-kB. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 68-76 17320862-3 2007 Aspirin, at 10, 30 and 100 mg/kg doses, increased IL-1beta levels in exudates, however, only the highest dose lead to a significant increase when compared to control, whereas a significant increase in TNF-alpha level was observed at all doses tested. Aspirin 0-7 interleukin 1 beta Rattus norvegicus 50-58 17320050-0 2007 NMDA-induced interleukin-1beta expression is mediated by nuclear factor-kappa B p65 in the retina. N-Methylaspartate 0-4 interleukin 1 beta Rattus norvegicus 13-30 17320050-2 2007 We examined the involvement of NF-kappaB p65 in N-methyl-D-aspartate (NMDA)-induced upregulation of interleukin (IL)-1beta, a proinflammatory cytokine, and subsequent neurotoxicity in the rat retina. N-Methylaspartate 48-68 interleukin 1 beta Rattus norvegicus 100-122 17320050-2 2007 We examined the involvement of NF-kappaB p65 in N-methyl-D-aspartate (NMDA)-induced upregulation of interleukin (IL)-1beta, a proinflammatory cytokine, and subsequent neurotoxicity in the rat retina. N-Methylaspartate 70-74 interleukin 1 beta Rattus norvegicus 100-122 17320050-3 2007 Immunohistochemistry showed that IL-1beta is localized not only in glial cells, but also in neurons, especially retinal ganglion cells (RGCs) after intravitreal injection of NMDA. N-Methylaspartate 174-178 interleukin 1 beta Rattus norvegicus 33-41 17320050-4 2007 Semi-quantitative real-time PCR showed that NMDA induces an increase in IL-1beta mRNA levels. N-Methylaspartate 44-48 interleukin 1 beta Rattus norvegicus 72-80 17320050-5 2007 Preinjection of NF-kappaB p65 antisense oligodeoxynucleotide (AS ODN) ameliorated the NMDA-induced increase in IL-1beta mRNA expression. Oligodeoxyribonucleotides 40-60 interleukin 1 beta Rattus norvegicus 111-119 17320050-5 2007 Preinjection of NF-kappaB p65 antisense oligodeoxynucleotide (AS ODN) ameliorated the NMDA-induced increase in IL-1beta mRNA expression. N-Methylaspartate 86-90 interleukin 1 beta Rattus norvegicus 111-119 17320050-6 2007 Western blot analysis showed elevated levels of retinal IL-1beta protein 12 h after intravitreal NMDA injection and this elevation was significantly inhibited by NF-kappaB p65 AS ODN. N-Methylaspartate 97-101 interleukin 1 beta Rattus norvegicus 56-64 17320050-8 2007 IL-1beta siRNA also had a protective effect on RGC number in NMDA-treated eyes. N-Methylaspartate 61-65 interleukin 1 beta Rattus norvegicus 0-8 17320050-10 2007 These results suggest that NF-kappaB p65 may participate in the induction of IL-1beta expression in NMDA-induced retinal neuronal cell death and that the inhibition of NF-kappaB p65 and IL-1beta with the use of AS ODN or siRNA may be a viable neuroprotective strategy for RGC survival. N-Methylaspartate 100-104 interleukin 1 beta Rattus norvegicus 77-85 17320132-8 2007 In addition, production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and vascular endothelial growth factor (VEGF) production induced by SCF was significantly inhibited by treatment with SC-236. 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide 204-210 interleukin 1 beta Rattus norvegicus 62-84 17368305-10 2007 SB203580 inhibited p38 MAPK and MPO activity, and reduced iNOS, COX-2, and IL-1beta protein or gene expression. SB 203580 0-8 interleukin 1 beta Rattus norvegicus 75-83 17520785-0 2007 Interleukin-1beta mediates sleep alteration in rats with rotenone-induced parkinsonism. Rotenone 57-65 interleukin 1 beta Rattus norvegicus 0-17 17304576-0 2007 Interleukin-1beta but not tumor necrosis factor-alpha potentiates neuronal damage by quinolinic acid: protection by an adenosine A2A receptor antagonist. Quinolinic Acid 85-100 interleukin 1 beta Rattus norvegicus 0-17 17304576-8 2007 The adenosine A(2A) receptor antagonist ZM241385 reduced neuronal loss produced by the combinations of quinolinic acid and IL-1beta. ZM 241385 40-48 interleukin 1 beta Rattus norvegicus 123-131 17414422-12 2007 When beta-glucan was administered, it completely blocked the elevation of TNF-alpha, IL-1beta, and IL-6. beta-Glucans 5-16 interleukin 1 beta Rattus norvegicus 85-93 17349015-9 2007 A moderate increase in baseline interleukin (IL)-1beta levels was observed in the SBGsc group (P< 0 x 05). sbgsc 82-87 interleukin 1 beta Rattus norvegicus 32-54 17265033-1 2007 AIMS/HYPOTHESIS: The immune-mediated elimination of pancreatic beta cells in type 1 diabetes involves release of cytotoxic cytokines such as IL-1beta and IFNgamma, which induce beta cell death in vitro by mechanisms that are both dependent and independent of nitric oxide (NO). Nitric Oxide 259-271 interleukin 1 beta Rattus norvegicus 141-149 17394460-8 2007 Rosiglitazone treatment curtailed the post-ischemic expression of the pro-inflammatory genes interleukin-1beta, interleukin-6, macrophage inflammatory protein-1alpha, monocyte chemoattractant protein-1, cyclooxygenase-2, inducible nitric oxide synthase, early growth response-1, CCAAT/enhancer binding protein-beta and nuclear factor-kappa B, and increased the expression of the anti-oxidant enzymes catalase and copper/zinc-superoxide dismutase. Rosiglitazone 0-13 interleukin 1 beta Rattus norvegicus 93-110 17504920-0 2007 Participation of phosphatidyl inositol 3-kinase/protein kinase B and ERK1/2 pathways in interleukin-1beta stimulation of lactate production in Sertoli cells. Lactic Acid 121-128 interleukin 1 beta Rattus norvegicus 88-105 17504920-6 2007 PD and W, but not R, decreased IL1beta-stimulated lactate production. Lactic Acid 50-57 interleukin 1 beta Rattus norvegicus 31-38 17504920-8 2007 It was observed that W decreased IL1beta-stimulated glucose uptake, whereas PD and R did not modify it. Glucose 52-59 interleukin 1 beta Rattus norvegicus 33-40 17504920-11 2007 Moreover, these results show that while IL1beta utilizes the PI3K/PKB pathway to regulate glucose transport, it utilizes the ERK1/2 pathway to regulate LDH A mRNA levels. Glucose 90-97 interleukin 1 beta Rattus norvegicus 40-47 17504920-12 2007 This study reveals that IL1beta utilizes different signal transduction pathways to modify the biochemical steps that are important to regulate lactate production in rat Sertoli cells. Lactic Acid 143-150 interleukin 1 beta Rattus norvegicus 24-31 17520785-15 2007 However, the results of enhanced expression of IL-1beta in the hypothalamus after rotenone and that of the blockade of sleep alteration, but not the locomotion activity, by intracerebroventricular administration of an IL-1 receptor antagonist implies that increased IL-1beta in the hypothalamus mediates sleep alteration, but not the locomotion, in rats with rotenone-induced parkinsonism. Rotenone 82-90 interleukin 1 beta Rattus norvegicus 47-55 17279089-0 2007 Negative inotropic effects of tumour necrosis factor-alpha and interleukin-1beta are ameliorated by alfentanil in rat ventricular myocytes. Alfentanil 100-110 interleukin 1 beta Rattus norvegicus 63-80 17188663-15 2007 In the olomoucine-treated group, a significant reduction of activated and/or proliferated microglial induced IL-1beta expression was observed 24 h after SCI. olomoucine 7-17 interleukin 1 beta Rattus norvegicus 109-117 17535659-1 2007 OBJECTIVE: To observe the change of cytokine interleukin IL-1 beta, IL-6, IL-10, tumor necrosis factor-alpha (TNF-alpha) occurred in acute paraquat (PQ) poisoning rats and to investigate the mechanism of acute lung injury caused by paraquat (PQ) poisoning. Paraquat 139-147 interleukin 1 beta Rattus norvegicus 57-66 17583206-5 2007 RESULT: Two kinds of water abstract induced significantly renal injury in rats, IL-1beta, IL-6 levels in renal homogenate were significantly increased compared with controls, histological section showed inflammatory cell infiltration play important role in renal tubulointerstitium damage. Water 21-26 interleukin 1 beta Rattus norvegicus 80-88 17279089-8 2007 Alfentanil significantly increased contraction of TNF-alpha and IL-1beta treated cells via a small increase in the Ca(2+) transient and a larger increase in myofilament Ca(2+) sensitivity, effects that were not blocked by 10 microM naloxone, a broad spectrum opioid receptor antagonist. Alfentanil 0-10 interleukin 1 beta Rattus norvegicus 64-72 17279089-8 2007 Alfentanil significantly increased contraction of TNF-alpha and IL-1beta treated cells via a small increase in the Ca(2+) transient and a larger increase in myofilament Ca(2+) sensitivity, effects that were not blocked by 10 microM naloxone, a broad spectrum opioid receptor antagonist. Naloxone 232-240 interleukin 1 beta Rattus norvegicus 64-72 17223105-7 2007 The oral pre-treatment with thalidomide decreased, in a dose-dependent manner, the number of inflammatory cells, the protein concentration, and the levels of IL-1beta and TNF-alpha in the AqH. Thalidomide 28-39 interleukin 1 beta Rattus norvegicus 158-166 17384995-8 2007 In addition, cell proliferative activity against IL-1beta or platelet-derived growth factor-BB was assessed by bromodeoxyuridine incorporation. Bromodeoxyuridine 111-128 interleukin 1 beta Rattus norvegicus 49-57 17204294-12 2007 The heatstroke-induced increased levels of IL-1beta and TNF-alpha in both the serum and hypothalamus, and renal and hepatic dysfunction were suppressed by baicalin pretreatment. baicalin 155-163 interleukin 1 beta Rattus norvegicus 43-51 17291994-4 2007 S-diclofenac administration downregulated expression of genes encoding enzymes which synthesize nitric oxide, prostanoids, and H2S; reduced plasma IL-1beta/TNF-alpha; and elevated plasma IL-10. Sulfur 0-1 interleukin 1 beta Rattus norvegicus 147-155 17291994-4 2007 S-diclofenac administration downregulated expression of genes encoding enzymes which synthesize nitric oxide, prostanoids, and H2S; reduced plasma IL-1beta/TNF-alpha; and elevated plasma IL-10. Diclofenac 2-12 interleukin 1 beta Rattus norvegicus 147-155 17242297-9 2007 Eplerenone, but not pyrrolidine dithiocarbamate, reduced plasma interleukin-1beta. Eplerenone 0-10 interleukin 1 beta Rattus norvegicus 64-81 17273805-6 2007 Incubation with ACE resulted in a significant reduction in IL-1beta and IFN-gamma-induced NO production, a finding that correlated well with reduced levels of the iNOS mRNA and protein. Acetaldehyde 16-19 interleukin 1 beta Rattus norvegicus 59-67 17167171-8 2007 At 6 h after SCI, the pioglitazone group showed significantly less induction of inflammatory genes [interleukin (IL)-6 by 83%, IL-1beta by 87%, monocyte chemoattractant protein-1 by 75%, intracellular adhesion molecule-1 by 84%, and early growth response-1 by 67%] compared with the vehicle group (p < 0.05 in all cases). Pioglitazone 22-34 interleukin 1 beta Rattus norvegicus 127-135 17349851-8 2007 The administration of hemin led to a significant decrease in the activation of p38 MAPK and myeloperoxidase and the gene and/or protein expression of iNOS, COX-2, and IL-1beta. Hemin 22-27 interleukin 1 beta Rattus norvegicus 167-175 17204250-2 2007 Transient middle cerebral artery occlusion (tMCAO) in spontaneously hypertensive rat (SHR) resulted in significant increases in TNF-alpha and IL-1beta levels. tmcao 44-49 interleukin 1 beta Rattus norvegicus 142-150 17196563-9 2007 Interestingly, mature IL-1beta protein was elevated in the hypothalamus of prenatally LAAM-treated rats. Methadyl Acetate 86-90 interleukin 1 beta Rattus norvegicus 22-30 17140731-9 2007 Pentoxifylline administration resulted in a dose-dependent reduction of the production of proinflammatory cytokines like TNFalpha, IL-1beta and IL-6, and enhancement of IL-10. Pentoxifylline 0-14 interleukin 1 beta Rattus norvegicus 131-139 17151863-5 2007 In the presence of 16.7 mmol/l glucose protein production of p47(phox) was increased by 1.7-fold in isolated rat islets after 1 h, while in the presence of 0.1 mmol/l palmitic acid or 5 ng/ml IL-1beta it was increased by 1.4-fold or 1.8-fold, respectively. Glucose 31-38 interleukin 1 beta Rattus norvegicus 192-200 17268059-4 2007 Presence of scoparone significantly protected interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma)-mediated cytotoxicity of RINm5F, a rat insulinoma cell line, and preserved glucose-stimulated insulin secretion in rat pancreatic islets. scoparone 12-21 interleukin 1 beta Rattus norvegicus 46-63 17268059-4 2007 Presence of scoparone significantly protected interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma)-mediated cytotoxicity of RINm5F, a rat insulinoma cell line, and preserved glucose-stimulated insulin secretion in rat pancreatic islets. scoparone 12-21 interleukin 1 beta Rattus norvegicus 65-73 17268059-4 2007 Presence of scoparone significantly protected interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma)-mediated cytotoxicity of RINm5F, a rat insulinoma cell line, and preserved glucose-stimulated insulin secretion in rat pancreatic islets. rinm5f 133-139 interleukin 1 beta Rattus norvegicus 46-63 17268059-5 2007 Scoparone also resulted in a significant reduction in IL-1beta and IFN-gamma-induced nitric oxide (NO) production, a finding that correlated well with reduced levels of the inducible form of NO synthase (iNOS) mRNA and protein. scoparone 0-9 interleukin 1 beta Rattus norvegicus 54-62 17151863-6 2007 However, palmitic acid or IL-1beta-dependent production was reduced after 24 h. Islet ROS production was significantly increased after incubation in elevated glucose for 1 h and was completely abolished by addition of diphenylene iodonium, an inhibitor of NADPH oxidase or by the oligonucleotide anti-p47(phox). Reactive Oxygen Species 86-89 interleukin 1 beta Rattus norvegicus 26-34 17151863-6 2007 However, palmitic acid or IL-1beta-dependent production was reduced after 24 h. Islet ROS production was significantly increased after incubation in elevated glucose for 1 h and was completely abolished by addition of diphenylene iodonium, an inhibitor of NADPH oxidase or by the oligonucleotide anti-p47(phox). Glucose 158-165 interleukin 1 beta Rattus norvegicus 26-34 17151863-6 2007 However, palmitic acid or IL-1beta-dependent production was reduced after 24 h. Islet ROS production was significantly increased after incubation in elevated glucose for 1 h and was completely abolished by addition of diphenylene iodonium, an inhibitor of NADPH oxidase or by the oligonucleotide anti-p47(phox). diphenyleneiodonium 218-238 interleukin 1 beta Rattus norvegicus 26-34 17151863-6 2007 However, palmitic acid or IL-1beta-dependent production was reduced after 24 h. Islet ROS production was significantly increased after incubation in elevated glucose for 1 h and was completely abolished by addition of diphenylene iodonium, an inhibitor of NADPH oxidase or by the oligonucleotide anti-p47(phox). Oligonucleotides 280-295 interleukin 1 beta Rattus norvegicus 26-34 17151863-7 2007 Addition of 0.1 mmol/l palmitic acid or 5 ng/ml IL-1beta plus 5.6 mmol/l glucose also resulted in a significant increase in islet ROS production after 1 h, which was partially attenuated by diphenylene iodonium or the protein kinase C inhibitor GF109203X. Reactive Oxygen Species 130-133 interleukin 1 beta Rattus norvegicus 48-56 17110428-0 2007 Osteopontin protects the islets and beta-cells from interleukin-1 beta-mediated cytotoxicity through negative feedback regulation of nitric oxide. Nitric Oxide 133-145 interleukin 1 beta Rattus norvegicus 52-70 17110428-3 2007 Here, we demonstrate that addition of OPN before IL-1beta in freshly isolated rat islets improved their glucose stimulated insulin secretion dose-dependently and inhibited IL-1beta-induced NO production in an arginine-glycine-aspartate-dependent manner. Glycine 218-225 interleukin 1 beta Rattus norvegicus 172-180 17110428-3 2007 Here, we demonstrate that addition of OPN before IL-1beta in freshly isolated rat islets improved their glucose stimulated insulin secretion dose-dependently and inhibited IL-1beta-induced NO production in an arginine-glycine-aspartate-dependent manner. Arginine 209-217 interleukin 1 beta Rattus norvegicus 172-180 17151863-7 2007 Addition of 0.1 mmol/l palmitic acid or 5 ng/ml IL-1beta plus 5.6 mmol/l glucose also resulted in a significant increase in islet ROS production after 1 h, which was partially attenuated by diphenylene iodonium or the protein kinase C inhibitor GF109203X. diphenyleneiodonium 190-210 interleukin 1 beta Rattus norvegicus 48-56 17110428-3 2007 Here, we demonstrate that addition of OPN before IL-1beta in freshly isolated rat islets improved their glucose stimulated insulin secretion dose-dependently and inhibited IL-1beta-induced NO production in an arginine-glycine-aspartate-dependent manner. Aspartic Acid 226-235 interleukin 1 beta Rattus norvegicus 172-180 17151863-7 2007 Addition of 0.1 mmol/l palmitic acid or 5 ng/ml IL-1beta plus 5.6 mmol/l glucose also resulted in a significant increase in islet ROS production after 1 h, which was partially attenuated by diphenylene iodonium or the protein kinase C inhibitor GF109203X. bisindolylmaleimide I 245-254 interleukin 1 beta Rattus norvegicus 48-56 21171372-0 2007 [Effects of IL-1beta on inducible nitric oxide synthase-nitric oxide system activity in arginine vasopressin-induced rat cardiac fibroblasts]. Nitric Oxide 34-46 interleukin 1 beta Rattus norvegicus 12-20 17283238-12 2007 We conclude that a sustained functional stimulation by glucose of islets is coupled to a decreased conversion of proinsulin which is also true for islets treated with IL-1beta. Glucose 55-62 interleukin 1 beta Rattus norvegicus 167-175 16949880-7 2007 IL-1beta was elevated 6 h after carrageenan injection in the hind paw tissue but only 24 h in the muscle tissue (P < .001). Carrageenan 32-43 interleukin 1 beta Rattus norvegicus 0-8 16829209-1 2007 Testosterone secretion by Leydig cells is affected by interleukin-1beta (IL-1beta). Testosterone 0-12 interleukin 1 beta Rattus norvegicus 54-71 21171372-1 2007 AIM: To explore the effects of interleukin-1beta (IL-1beta) on inducible nitric oxide synthase (iNOS)-nitric oxide (NO) system activity in arginine vasopressin (AVP)-induced rat cardiac fibroblasts (CFs). Nitric Oxide 73-85 interleukin 1 beta Rattus norvegicus 31-48 16829209-1 2007 Testosterone secretion by Leydig cells is affected by interleukin-1beta (IL-1beta). Testosterone 0-12 interleukin 1 beta Rattus norvegicus 73-81 21171372-1 2007 AIM: To explore the effects of interleukin-1beta (IL-1beta) on inducible nitric oxide synthase (iNOS)-nitric oxide (NO) system activity in arginine vasopressin (AVP)-induced rat cardiac fibroblasts (CFs). Nitric Oxide 73-85 interleukin 1 beta Rattus norvegicus 50-58 16829209-4 2007 One day after treatment with local injection of IL-1beta induced a significant rise in testosterone secretion that could be prevented by vasectomy (that also means transection of the inferior spermatic nerve). Testosterone 87-99 interleukin 1 beta Rattus norvegicus 48-56 16829209-5 2007 In a model in which neither IL-1beta nor ketanserin interfered with steroidogenesis, administration of the receptor antagonist just prior to IL-1beta treatment significantly reduced testosterone secretion. Testosterone 182-194 interleukin 1 beta Rattus norvegicus 141-149 17112678-12 2007 Treatment with CMZ ameliorated the increases in IL-1alpha, IL-1beta, TNF-alpha and GM-CSF levels while increasing plasma IL-4 and IL-10 levels. Chlormethiazole 15-18 interleukin 1 beta Rattus norvegicus 59-67 16829209-6 2007 Data indicate interaction between testicular nerves and IL-1beta action and interaction between testicular 5-HT2 receptors and local effect of IL-1beta on testosterone secretion. Testosterone 155-167 interleukin 1 beta Rattus norvegicus 143-151 17224798-6 2007 L-NAME significantly increased the lymph levels of IL-1beta and IL-10; in serum, however, only IL-1beta increased in rats with either intact or ligated thoracic lymph duct. NG-Nitroarginine Methyl Ester 0-6 interleukin 1 beta Rattus norvegicus 51-59 17224798-7 2007 The treatment with PTX reduced the serum levels of IL-1beta irrespective of the lymph circulation interruption but was effective to increase the IL-10 levels in intact rats during I/R. Pentoxifylline 19-22 interleukin 1 beta Rattus norvegicus 51-59 17224798-8 2007 The lymphatic levels of IL-1beta of rats subjected to I/R were reduced and those of IL-10 were increased after treatment with PTX. Pentoxifylline 126-129 interleukin 1 beta Rattus norvegicus 24-32 17179956-10 2007 Treatment with SB 239063 significantly reduced cytokine expression of tumour necrosis factor and interleukin-1beta after myocardial infarction. SB 239063 15-24 interleukin 1 beta Rattus norvegicus 97-114 17278232-9 2007 RESULTS: Serum IL-1beta levels in SAP-S group were 276.77 +/- 44.92 pg/mL at 6 h, 308.99 +/- 34.95 pg/mL at 12 h, and 311.60 +/- 46.51 pg/mL at 18 h, which were increased significantly (P < 0.01, vs HC). sap-s 34-39 interleukin 1 beta Rattus norvegicus 15-23 17678975-7 2007 Pharmacological manipulation of MMPs activity, using the broad spectrum MMPs inhibitor GM6001, reduces the increase in IL-1beta immunoreactivity and the neuronal apoptosis induced by gp120. N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide 87-93 interleukin 1 beta Rattus norvegicus 119-127 17049356-6 2007 CTS inhibited the IL-1beta-stimulated synthesis of TNF-alpha, TNFR2, and iNOS. castanospermine 0-3 interleukin 1 beta Rattus norvegicus 18-26 17678960-7 2007 More importantly, when administered at a neuroprotective dose GM6001 abolishes the early IL-1beta increase in the ischemic cortex and reduces the cleavage of the cytokine proform supporting the deduction that MMPs may initiate IL-1beta processing. N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide 62-68 interleukin 1 beta Rattus norvegicus 89-97 17641529-7 2007 RESULTS: Cisplatin injection induced neutrophil recruitment and increased tumor necrosis factor-alpha and interleukin-1beta contents in renal cortices and outer medullae tissues. Cisplatin 9-18 interleukin 1 beta Rattus norvegicus 106-123 17678960-7 2007 More importantly, when administered at a neuroprotective dose GM6001 abolishes the early IL-1beta increase in the ischemic cortex and reduces the cleavage of the cytokine proform supporting the deduction that MMPs may initiate IL-1beta processing. N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide 62-68 interleukin 1 beta Rattus norvegicus 227-235 17678971-0 2007 Evidence to implicate early modulation of interleukin-1beta expression in the neuroprotection afforded by 17beta-estradiol in male rats undergone transient middle cerebral artery occlusion. Estradiol 106-122 interleukin 1 beta Rattus norvegicus 42-59 17678971-5 2007 Here we investigate whether reduced brain damage by acute pharmacological treatment with 17beta-E(2) in male rats subjected to transient (2h) middle cerebral artery occlusion (tMCAo) involves modulation of interleukin-1beta (IL-1beta), a proinflammatory cytokine strongly implicated in the pathophysiology of ischemic stroke. 17beta-e 89-97 interleukin 1 beta Rattus norvegicus 206-223 17678971-5 2007 Here we investigate whether reduced brain damage by acute pharmacological treatment with 17beta-E(2) in male rats subjected to transient (2h) middle cerebral artery occlusion (tMCAo) involves modulation of interleukin-1beta (IL-1beta), a proinflammatory cytokine strongly implicated in the pathophysiology of ischemic stroke. 17beta-e 89-97 interleukin 1 beta Rattus norvegicus 225-233 17678971-5 2007 Here we investigate whether reduced brain damage by acute pharmacological treatment with 17beta-E(2) in male rats subjected to transient (2h) middle cerebral artery occlusion (tMCAo) involves modulation of interleukin-1beta (IL-1beta), a proinflammatory cytokine strongly implicated in the pathophysiology of ischemic stroke. tmcao 176-181 interleukin 1 beta Rattus norvegicus 206-223 17678971-11 2007 In conclusion, we report the original observation that neuroprotection exerted by 17beta-E(2) in a rat model of transient focal brain ischemia is accompanied by reduced cytochrome c translocation to the cytosol and involves early modulation of IL-1beta production. 17beta-e 82-90 interleukin 1 beta Rattus norvegicus 244-252 17259747-8 2007 RESULTS: Serum ALT, AST, and LDH activities and TNF-alpha and IL-1beta levels were elevated in the I/R group, while this increase was significantly lower in the group of animals treated concomitantly with lipoic acid. Thioctic Acid 205-216 interleukin 1 beta Rattus norvegicus 62-70 17941462-9 2007 Administration of fluconazole or Lacidofil significantly decreased the weight of colon segments, the MPO activity and the plasma IL-1beta and TNF-alpha levels, as compared with respective values in the group receiving Candida only. Fluconazole 18-29 interleukin 1 beta Rattus norvegicus 129-137 17941462-9 2007 Administration of fluconazole or Lacidofil significantly decreased the weight of colon segments, the MPO activity and the plasma IL-1beta and TNF-alpha levels, as compared with respective values in the group receiving Candida only. lacidofil 33-42 interleukin 1 beta Rattus norvegicus 129-137 17713352-7 2007 In the prefrontal cortex, the OBX group showed significantly higher concentrations of tumour necrosis factor alpha (z = -2.205, p = 0.028) and IL-1beta (z = -3.361, p = 0.001) than the OBX + celecoxib group, but a significantly lower concentration of IL-10 (p = -3.361, p = 0.001) than the OBX + celecoxib group. obx 30-33 interleukin 1 beta Rattus norvegicus 143-151 17030435-5 2006 Pre-treatment, as well as post-treatment with (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (APDC), a group II mGluR agonist, blocked either IL-1beta-induced mechanical allodynia or mirror-image mechanical allodynia. 4-aminopyrrolidine-2,4-dicarboxylic acid 46-90 interleukin 1 beta Rattus norvegicus 140-148 17172986-7 2007 In vitro trehalose significantly blunted LPS-induced extracellular-regulated kinase (LPS = 21 +/- 6 integrated intensity; LPS + trehalose 100 mmol = 2 +/- 0.3 integrated intensity), c-jun-N terminal kinase (LPS = 15 +/- 5 integrated intensity; LPS + trehalose 100 mmol = 3.5 +/- 0.9 integrated intensity), and inducible nitric oxide synthase activation (LPS = 12 +/- 3 integrated intensity; LPS + trehalose 100 mmol = 1 +/- 0.09 integrated intensity), blunted IL-1beta (LPS = 5 +/- 1.9 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.5 +/- 0.8 n-folds/beta-actin), IL-6 (LPS = 4 +/- 1.5 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.4 +/- 0.5 n-folds/beta-actin), and TNF-alpha (LPS = 4.2 +/- 1.6 n-folds/beta-actin; LPS + trehalose 100 mmol = 1.1 +/- 0.7 n-folds/beta-actin) gene expression, and markedly reduced the release of inflammatory cytokines and nitrite content. Trehalose 9-18 interleukin 1 beta Rattus norvegicus 460-468 17030435-5 2006 Pre-treatment, as well as post-treatment with (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (APDC), a group II mGluR agonist, blocked either IL-1beta-induced mechanical allodynia or mirror-image mechanical allodynia. Ammonium pyrrolidyldithiocarbamate 92-96 interleukin 1 beta Rattus norvegicus 140-148 17011047-2 2006 The cannabinoid receptor agonist, HU210 attenuated lipopolysaccharide (LPS)-induced increases in IL-1beta and TNFalpha in rat brain and IL-1beta, TNFalpha, IL-6 and IFNgamma in plasma. HU 211 34-39 interleukin 1 beta Rattus norvegicus 97-105 17137520-0 2006 Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1beta and inducible nitric oxide synthase in the rat model of Alzheimer"s disease. berberine chloride 0-18 interleukin 1 beta Rattus norvegicus 95-112 17137520-3 2006 The present study was carried out to investigate the effect of berberine chloride on the spatial memory, inflammation factors interleukin-1 beta (IL-1beta) and inducible nitric oxide synthase (iNOS) expression in the rat model of Alzheimer"s disease (AD) which was established by injecting Abeta (1-40) (5 microgram) into the rats hippocampuses bilaterally. berberine chloride 63-81 interleukin 1 beta Rattus norvegicus 126-144 17130506-9 2006 Inhibition of glycosphingolipid synthesis also suppressed glucosamine- and interleukin-1beta-induced death. Glycosphingolipids 14-31 interleukin 1 beta Rattus norvegicus 75-92 16972262-5 2006 We found that islets of non-diabetic BB rats became positive to both IL-1beta and IL-4 very early on, confirming a local but intense production of both cytokines within the islets during the initial non-diabetic period. boeravinone B 37-39 interleukin 1 beta Rattus norvegicus 69-77 17011047-2 2006 The cannabinoid receptor agonist, HU210 attenuated lipopolysaccharide (LPS)-induced increases in IL-1beta and TNFalpha in rat brain and IL-1beta, TNFalpha, IL-6 and IFNgamma in plasma. HU 211 34-39 interleukin 1 beta Rattus norvegicus 136-144 17076768-0 2006 Response of interleukin-1beta in the magnocellular system to salt-loading. Salts 61-65 interleukin 1 beta Rattus norvegicus 12-29 17076768-9 2006 In the neural lobe, all three peptides decreased progressively with increasing duration of salt-loading (IL-1beta, r2 = 0.98; OT, r2 = 0.94; VP, r2 = 0.93), beginning on day 2 (IL-1beta; VP) or 5 (OT), with only VP replenished by rehydration. Salts 91-95 interleukin 1 beta Rattus norvegicus 105-113 17076768-11 2006 Local effects of IL-1beta on magnocellular terminals, pituicytes and microglia in the neural lobe with activation of forebrain osmoregulatory structures by circulating cytokine may sustain neurosecretion of OT and VP during prolonged salt-loading. Salts 234-238 interleukin 1 beta Rattus norvegicus 17-25 17011047-3 2006 The CB(1) receptor antagonist, SR141716A, attenuated the immunosupressive effects of HU210 on IL-1beta, but not TNFalpha. Rimonabant 31-40 interleukin 1 beta Rattus norvegicus 94-102 17011047-3 2006 The CB(1) receptor antagonist, SR141716A, attenuated the immunosupressive effects of HU210 on IL-1beta, but not TNFalpha. HU 211 85-90 interleukin 1 beta Rattus norvegicus 94-102 21155270-0 2006 [The effects of Tetrandrine on the changes of IL-1beta, TNF-alpha and IL-8 after cerebral ischemia/reperfusion in rats]. tetrandrine 16-27 interleukin 1 beta Rattus norvegicus 46-54 17235413-8 2006 Furthermore, pioglitazone upregulated the suppressed expression of PPARgamma and attenuated the increased IL-1beta and IL-6 expression. Pioglitazone 13-25 interleukin 1 beta Rattus norvegicus 106-114 17129391-11 2006 This conclusion is based on the above mentioned published data and the current findings showing animals treated with PFOA alone or in combination with methylpalmitate to have similar levels of serum TNFalpha and IL-1beta, which are reliable indicators of Kupffer cell activity, despite a remarkable difference in hepatocellular proliferation. perfluorooctanoic acid 117-121 interleukin 1 beta Rattus norvegicus 212-220 17067358-13 2006 Ethanol also impaired LPS-induced levels of IL-1beta and TNF-alpha mRNAs both in the spleen and in the ARC. Ethanol 0-7 interleukin 1 beta Rattus norvegicus 44-52 17077517-0 2006 2-methoxycinnamaldehyde reduces IL-1beta-induced prostaglandin production in rat cerebral endothelial cells. 2-methoxycinnamaldehyde 0-23 interleukin 1 beta Rattus norvegicus 32-40 17077517-0 2006 2-methoxycinnamaldehyde reduces IL-1beta-induced prostaglandin production in rat cerebral endothelial cells. Prostaglandins 49-62 interleukin 1 beta Rattus norvegicus 32-40 17077517-5 2006 2-Methoxycinnamaldehyde dose-dependently inhibited interleukin (IL)-1beta-induced PGE2 production in CECs with IC50 values of 174 microM. 2-methoxycinnamaldehyde 0-23 interleukin 1 beta Rattus norvegicus 51-73 17077517-5 2006 2-Methoxycinnamaldehyde dose-dependently inhibited interleukin (IL)-1beta-induced PGE2 production in CECs with IC50 values of 174 microM. Dinoprostone 82-86 interleukin 1 beta Rattus norvegicus 51-73 17077517-7 2006 2-Methoxycinnamaldehyde reduced IL-1beta-induced protein and activity of COX-2, but did not influence the COX-2 mRNA expression. 2-methoxycinnamaldehyde 0-23 interleukin 1 beta Rattus norvegicus 32-40 17027164-2 2006 Initially, we examined whether glutamate, hydrogen peroxide (H(2)O(2)), interleukin-1 (IL-1) beta, and sodium nitroprusside (SNP) induce the secretion of l-Ser in astrocytes isolated from Wistar Kyoto rats (WKY). Serine 154-159 interleukin 1 beta Rattus norvegicus 87-97 16934228-0 2006 Suppression of IL-1beta expression by the Jak 2 inhibitor AG490 in cerulein-stimulated pancreatic acinar cells. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 58-63 interleukin 1 beta Rattus norvegicus 15-23 16934228-8 2006 As a result, cerulein induced the activation of Jak2 and Stat3 as well as IL-1beta expression, which was inhibited by the treatment of AG490 in AR42J cells. Ceruletide 13-21 interleukin 1 beta Rattus norvegicus 74-82 17076683-0 2006 Low doses of tumour necrosis factor alpha and interleukin 1beta diminish hepatic gluconeogenesis from alanine in vivo. Alanine 102-109 interleukin 1 beta Rattus norvegicus 46-63 16750340-6 2006 Pretreatment of rats with PE at oral dose of 25, 50 and 75 mg/kg or SL (silymarin, a reference hepatoprotective agent) at 5 mg/kg, 4 h before ethanol, lowered the ethanol induced levels of AST, ALT and IL-1beta. pe 26-28 interleukin 1 beta Rattus norvegicus 202-210 16750340-6 2006 Pretreatment of rats with PE at oral dose of 25, 50 and 75 mg/kg or SL (silymarin, a reference hepatoprotective agent) at 5 mg/kg, 4 h before ethanol, lowered the ethanol induced levels of AST, ALT and IL-1beta. Silymarin 72-81 interleukin 1 beta Rattus norvegicus 202-210 17018335-5 2006 Intracisternal administration of APDC, a group II mGluR agonist, or L-AP4, a group III mGluR agonist, reduced both IL-1beta-induced mechanical allodynia and mirror-image mechanical allodynia. Ammonium pyrrolidyldithiocarbamate 33-37 interleukin 1 beta Rattus norvegicus 115-123 16860347-2 2006 In a previous study, we found that pretreatment with NAC attenuated organ dysfunction and damage, reduced the production of free radicals, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) following endotoxemia elicited by administration of lipopolysaccharide (LPS). Acetylcysteine 53-56 interleukin 1 beta Rattus norvegicus 183-200 16860347-2 2006 In a previous study, we found that pretreatment with NAC attenuated organ dysfunction and damage, reduced the production of free radicals, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) following endotoxemia elicited by administration of lipopolysaccharide (LPS). Acetylcysteine 53-56 interleukin 1 beta Rattus norvegicus 202-210 16794003-2 2006 The cytokines, IL-1beta and interferon-gamma, induced terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) staining of rat islet cells within 48 h by about 25-30%, indicative of apoptosis and/or necrosis. deoxyuridine triphosphate 101-126 interleukin 1 beta Rattus norvegicus 15-23 16879708-3 2006 Exposure of pure microglial cultures to lipoteichoic acid triggered a significant time- and dose-dependent production of pro-inflammatory cytokines (tumour-necrosis factor-alpha, interleukin-1beta, interleukin-6) and nitric oxide. lipoteichoic acid 40-57 interleukin 1 beta Rattus norvegicus 179-196 17033518-8 2006 Likewise, dexamethasone decreased TNF-alpha and IL-1beta gene expression but did not affect TGF-betas in either epithelial or myofibroblast cells. Dexamethasone 10-23 interleukin 1 beta Rattus norvegicus 48-56 17018335-5 2006 Intracisternal administration of APDC, a group II mGluR agonist, or L-AP4, a group III mGluR agonist, reduced both IL-1beta-induced mechanical allodynia and mirror-image mechanical allodynia. 2-amino-4-phosphono-propinate 68-73 interleukin 1 beta Rattus norvegicus 115-123 16621158-5 2006 Since it has been documented that astrocytes release PGE2 in response to IL-1beta, we examined the effect of indomethacin (a PGE2 synthesis inhibitor) on mixed or neuron-enriched cultures treated with IL-1beta. Dinoprostone 53-57 interleukin 1 beta Rattus norvegicus 73-81 16452991-4 2006 Indeed, Interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) stimulated serotonin uptake in both the rat embryonic raphe cell line, RN46A, and in mouse midbrain and striatal synaptosomes. Serotonin 92-101 interleukin 1 beta Rattus norvegicus 8-25 16621158-6 2006 Indomethacin blocked both stimulatory and inhibitory IL-1beta effects on BDNF mRNA expression whereas picrotoxin (a GABA(A) blocker) or MK-801 (a NMDA receptor blocker) had no effect on BDNF mRNA levels. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 53-61 16452991-4 2006 Indeed, Interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) stimulated serotonin uptake in both the rat embryonic raphe cell line, RN46A, and in mouse midbrain and striatal synaptosomes. Serotonin 92-101 interleukin 1 beta Rattus norvegicus 27-35 16452991-8 2006 Western blots showed that IL-1beta and TNF-alpha activated p38 MAPK, in an SB203580-sensitive manner. SB 203580 75-83 interleukin 1 beta Rattus norvegicus 26-34 16621158-7 2006 About 3 and 6h treatments of cells with exogenous PGE2 reproduced the effects of IL-1beta on neuron-enriched or on mixed cultures suggesting that PGE2 was involved in BDNF mRNA regulation. Dinoprostone 50-54 interleukin 1 beta Rattus norvegicus 81-89 16452991-9 2006 IL-1beta induced an SB203580-sensitive decrease in 5-HT Km with no significant change in Vmax. SB 203580 20-28 interleukin 1 beta Rattus norvegicus 0-8 16452991-13 2006 As with RN46A cells, the effects of IL-1beta and TNF-alpha were completely (IL-1beta) or partially (TNF-alpha) blocked by SB203580. SB 203580 122-130 interleukin 1 beta Rattus norvegicus 36-44 16452991-13 2006 As with RN46A cells, the effects of IL-1beta and TNF-alpha were completely (IL-1beta) or partially (TNF-alpha) blocked by SB203580. SB 203580 122-130 interleukin 1 beta Rattus norvegicus 76-84 16621158-7 2006 About 3 and 6h treatments of cells with exogenous PGE2 reproduced the effects of IL-1beta on neuron-enriched or on mixed cultures suggesting that PGE2 was involved in BDNF mRNA regulation. Dinoprostone 146-150 interleukin 1 beta Rattus norvegicus 81-89 16960100-5 2006 Eplerenone-treated HF rats had lower plasma TNF-alpha, interleukin (IL)-1beta and IL-6, less COX-2 staining of small blood vessels penetrating PVN, fewer PVN neurons expressing Fra-like activity (indicating chronic neuronal activation), and fewer PVN neurons staining for TNF-alpha, IL-1beta, and CRH than vehicle-treated HF rats. Eplerenone 0-10 interleukin 1 beta Rattus norvegicus 55-77 16840564-8 2006 Interleukin-1beta and total antioxidant potential in lung tissues were also increased in rats exposed to CFA. 3-chloro-4-fluoroaniline 105-108 interleukin 1 beta Rattus norvegicus 0-17 16960100-5 2006 Eplerenone-treated HF rats had lower plasma TNF-alpha, interleukin (IL)-1beta and IL-6, less COX-2 staining of small blood vessels penetrating PVN, fewer PVN neurons expressing Fra-like activity (indicating chronic neuronal activation), and fewer PVN neurons staining for TNF-alpha, IL-1beta, and CRH than vehicle-treated HF rats. Eplerenone 0-10 interleukin 1 beta Rattus norvegicus 283-291 16876321-8 2006 PBN significantly inhibited HI-induced up-regulation of IL-1beta, TNF-alpha and iNOS mRNA expression at 4h following HI. phenyl-N-tert-butylnitrone 0-3 interleukin 1 beta Rattus norvegicus 56-64 16876321-8 2006 PBN significantly inhibited HI-induced up-regulation of IL-1beta, TNF-alpha and iNOS mRNA expression at 4h following HI. hi 28-30 interleukin 1 beta Rattus norvegicus 56-64 16876321-9 2006 PBN treatment also reduced the brain concentration of IL-1beta significantly and decreased the number of IL-1beta- or iNOS-expressing cells in the white matter area at 12h following HI. phenyl-N-tert-butylnitrone 0-3 interleukin 1 beta Rattus norvegicus 54-62 16876321-9 2006 PBN treatment also reduced the brain concentration of IL-1beta significantly and decreased the number of IL-1beta- or iNOS-expressing cells in the white matter area at 12h following HI. phenyl-N-tert-butylnitrone 0-3 interleukin 1 beta Rattus norvegicus 105-113 16959029-12 2006 Production of TNF-alpha and IL-1beta, measured after 24 hours of Abeta treatment, was also prevented by apocynin, catalase and EUKs, but the early release (measured after 1 hour of Abeta treatment) of TNF-alpha was insensitive to apocynin or catalase. UNII-042A8N37WH 65-70 interleukin 1 beta Rattus norvegicus 28-36 16880766-3 2006 EXPERIMENTAL APPROACHES: Tone induced by phenylephrine in aortic rings was measured after exposure in vitro to ambient lipopolysaccharide (LPS) or the proinflammatory cytokine interleukin-1beta (IL-1beta) for 6h, with or without MMP inhibitors (doxycycline or GM6001). Phenylephrine 41-54 interleukin 1 beta Rattus norvegicus 176-193 16574981-8 2006 In CCl(4)-induced liver injury, IL-6, IL-1beta, TNF-alpha, and IFN-gamma upregulation were found at the maximum 12 h after the administration of the toxin. Cefaclor 3-6 interleukin 1 beta Rattus norvegicus 38-46 16880766-3 2006 EXPERIMENTAL APPROACHES: Tone induced by phenylephrine in aortic rings was measured after exposure in vitro to ambient lipopolysaccharide (LPS) or the proinflammatory cytokine interleukin-1beta (IL-1beta) for 6h, with or without MMP inhibitors (doxycycline or GM6001). Phenylephrine 41-54 interleukin 1 beta Rattus norvegicus 195-203 16880766-5 2006 KEY RESULTS: Inhibition of MMP prevented the loss of phenylephrine-induced tone in aortic rings after LPS or IL-1beta. Phenylephrine 53-66 interleukin 1 beta Rattus norvegicus 109-117 16697108-9 2006 Glial cells activation and increased cytokine expression (TNFalpha, IL-1beta, and IL-6) in the rat spinal cord were induced by the 5-day morphine infusion and these neuroimmune responses were also prevented by amitriptyline co-infusion. Morphine 137-145 interleukin 1 beta Rattus norvegicus 68-76 16330180-6 2006 IL-1beta injections resulted in prolonged elevations of microdialysate NE, as well as plasma ACTH and corticosterone, and body temperature. Corticosterone 102-116 interleukin 1 beta Rattus norvegicus 0-8 16330180-8 2006 Pretreatment with indomethacin (10 mg/kg sc) prevented the IL-1beta-induced increases in body temperature and the apparent increase in hypothalamic NE release, but only attenuated the IL-1beta-induced shivering and the increase in plasma ACTH. Indomethacin 18-30 interleukin 1 beta Rattus norvegicus 59-67 16330180-8 2006 Pretreatment with indomethacin (10 mg/kg sc) prevented the IL-1beta-induced increases in body temperature and the apparent increase in hypothalamic NE release, but only attenuated the IL-1beta-induced shivering and the increase in plasma ACTH. Indomethacin 18-30 interleukin 1 beta Rattus norvegicus 184-192 16697108-9 2006 Glial cells activation and increased cytokine expression (TNFalpha, IL-1beta, and IL-6) in the rat spinal cord were induced by the 5-day morphine infusion and these neuroimmune responses were also prevented by amitriptyline co-infusion. Amitriptyline 210-223 interleukin 1 beta Rattus norvegicus 68-76 16814279-6 2006 Nimesulide or indomethacin administered i.p 30 min prior LPS, IL-1beta, IL-6, TNF-alpha or arachidonic acid reduced the febrile response and PGE(2) or PGF(2alpha) levels in LPS-febrile rats but did not modify PGE(2)-induced fever. nimesulide 0-10 interleukin 1 beta Rattus norvegicus 62-70 16814279-6 2006 Nimesulide or indomethacin administered i.p 30 min prior LPS, IL-1beta, IL-6, TNF-alpha or arachidonic acid reduced the febrile response and PGE(2) or PGF(2alpha) levels in LPS-febrile rats but did not modify PGE(2)-induced fever. Indomethacin 14-26 interleukin 1 beta Rattus norvegicus 62-70 16814279-6 2006 Nimesulide or indomethacin administered i.p 30 min prior LPS, IL-1beta, IL-6, TNF-alpha or arachidonic acid reduced the febrile response and PGE(2) or PGF(2alpha) levels in LPS-febrile rats but did not modify PGE(2)-induced fever. Prostaglandins E 141-144 interleukin 1 beta Rattus norvegicus 62-70 16824509-0 2006 Changes in brain interleukin-1beta following the coadministration of norfloxacin with biphenylacetic acid in rats. Norfloxacin 69-80 interleukin 1 beta Rattus norvegicus 17-34 16814279-6 2006 Nimesulide or indomethacin administered i.p 30 min prior LPS, IL-1beta, IL-6, TNF-alpha or arachidonic acid reduced the febrile response and PGE(2) or PGF(2alpha) levels in LPS-febrile rats but did not modify PGE(2)-induced fever. Prostaglandins F 151-154 interleukin 1 beta Rattus norvegicus 62-70 16879255-8 2006 Analysis of cytokine mRNA expression in lymph nodes 10 days after immunzation revealed an increased expression of interferon (IFN)-gamma mRNA and interleukin (IL)-1beta mRNA in CII-Cl-immunized rats compared to CII-immunized rats. cii-cl 177-183 interleukin 1 beta Rattus norvegicus 146-168 16824509-0 2006 Changes in brain interleukin-1beta following the coadministration of norfloxacin with biphenylacetic acid in rats. biphenylylacetic acid 86-105 interleukin 1 beta Rattus norvegicus 17-34 16824509-1 2006 We sought to determine the changes in brain interleukin-1beta (IL-1beta) following the coadministration of norfloxacin (25 mg/kg, i.p.) Norfloxacin 107-118 interleukin 1 beta Rattus norvegicus 44-61 16824509-1 2006 We sought to determine the changes in brain interleukin-1beta (IL-1beta) following the coadministration of norfloxacin (25 mg/kg, i.p.) Norfloxacin 107-118 interleukin 1 beta Rattus norvegicus 63-71 16824509-9 2006 Norfloxacin plus biphenylacetic acid-induced convulsions rapidly and transiently enhanced IL-1beta mRNA in the prefrontal cortex and hippocampus. Norfloxacin 0-11 interleukin 1 beta Rattus norvegicus 90-98 16824509-9 2006 Norfloxacin plus biphenylacetic acid-induced convulsions rapidly and transiently enhanced IL-1beta mRNA in the prefrontal cortex and hippocampus. biphenylylacetic acid 17-36 interleukin 1 beta Rattus norvegicus 90-98 16824509-10 2006 IL-1beta mRNA expression in the prefrontal cortex and hippocampus was detected as soon as 30 min after norfloxacin injection, and decayed to control levels by 6 h. ELISA analysis revealed significant increase of the IL-1beta protein in the prefrontal cortex and hippocampus at 2 h and 6 h. Administration of either norfloxacin or biphenylacetic acid alone did not elicit convulsions and increase in IL-1beta mRNA and protein expressions. Norfloxacin 103-114 interleukin 1 beta Rattus norvegicus 0-8 16824509-10 2006 IL-1beta mRNA expression in the prefrontal cortex and hippocampus was detected as soon as 30 min after norfloxacin injection, and decayed to control levels by 6 h. ELISA analysis revealed significant increase of the IL-1beta protein in the prefrontal cortex and hippocampus at 2 h and 6 h. Administration of either norfloxacin or biphenylacetic acid alone did not elicit convulsions and increase in IL-1beta mRNA and protein expressions. Norfloxacin 103-114 interleukin 1 beta Rattus norvegicus 216-224 16824509-10 2006 IL-1beta mRNA expression in the prefrontal cortex and hippocampus was detected as soon as 30 min after norfloxacin injection, and decayed to control levels by 6 h. ELISA analysis revealed significant increase of the IL-1beta protein in the prefrontal cortex and hippocampus at 2 h and 6 h. Administration of either norfloxacin or biphenylacetic acid alone did not elicit convulsions and increase in IL-1beta mRNA and protein expressions. Norfloxacin 103-114 interleukin 1 beta Rattus norvegicus 216-224 16824509-10 2006 IL-1beta mRNA expression in the prefrontal cortex and hippocampus was detected as soon as 30 min after norfloxacin injection, and decayed to control levels by 6 h. ELISA analysis revealed significant increase of the IL-1beta protein in the prefrontal cortex and hippocampus at 2 h and 6 h. Administration of either norfloxacin or biphenylacetic acid alone did not elicit convulsions and increase in IL-1beta mRNA and protein expressions. Norfloxacin 315-326 interleukin 1 beta Rattus norvegicus 0-8 16824509-10 2006 IL-1beta mRNA expression in the prefrontal cortex and hippocampus was detected as soon as 30 min after norfloxacin injection, and decayed to control levels by 6 h. ELISA analysis revealed significant increase of the IL-1beta protein in the prefrontal cortex and hippocampus at 2 h and 6 h. Administration of either norfloxacin or biphenylacetic acid alone did not elicit convulsions and increase in IL-1beta mRNA and protein expressions. Norfloxacin 315-326 interleukin 1 beta Rattus norvegicus 216-224 16824509-10 2006 IL-1beta mRNA expression in the prefrontal cortex and hippocampus was detected as soon as 30 min after norfloxacin injection, and decayed to control levels by 6 h. ELISA analysis revealed significant increase of the IL-1beta protein in the prefrontal cortex and hippocampus at 2 h and 6 h. Administration of either norfloxacin or biphenylacetic acid alone did not elicit convulsions and increase in IL-1beta mRNA and protein expressions. Norfloxacin 315-326 interleukin 1 beta Rattus norvegicus 216-224 16824509-10 2006 IL-1beta mRNA expression in the prefrontal cortex and hippocampus was detected as soon as 30 min after norfloxacin injection, and decayed to control levels by 6 h. ELISA analysis revealed significant increase of the IL-1beta protein in the prefrontal cortex and hippocampus at 2 h and 6 h. Administration of either norfloxacin or biphenylacetic acid alone did not elicit convulsions and increase in IL-1beta mRNA and protein expressions. biphenylylacetic acid 330-349 interleukin 1 beta Rattus norvegicus 0-8 16824509-10 2006 IL-1beta mRNA expression in the prefrontal cortex and hippocampus was detected as soon as 30 min after norfloxacin injection, and decayed to control levels by 6 h. ELISA analysis revealed significant increase of the IL-1beta protein in the prefrontal cortex and hippocampus at 2 h and 6 h. Administration of either norfloxacin or biphenylacetic acid alone did not elicit convulsions and increase in IL-1beta mRNA and protein expressions. biphenylylacetic acid 330-349 interleukin 1 beta Rattus norvegicus 216-224 16824509-10 2006 IL-1beta mRNA expression in the prefrontal cortex and hippocampus was detected as soon as 30 min after norfloxacin injection, and decayed to control levels by 6 h. ELISA analysis revealed significant increase of the IL-1beta protein in the prefrontal cortex and hippocampus at 2 h and 6 h. Administration of either norfloxacin or biphenylacetic acid alone did not elicit convulsions and increase in IL-1beta mRNA and protein expressions. biphenylylacetic acid 330-349 interleukin 1 beta Rattus norvegicus 216-224 16824509-11 2006 The results suggest that the increased IL-1beta expressions in the prefrontal cortex and hippocampus induced by norfloxacin with biphenylacetic acid relate to seizure activities, and that these brain regions play pivotal roles in norfloxacin-induced convulsions. Norfloxacin 112-123 interleukin 1 beta Rattus norvegicus 39-47 16824509-11 2006 The results suggest that the increased IL-1beta expressions in the prefrontal cortex and hippocampus induced by norfloxacin with biphenylacetic acid relate to seizure activities, and that these brain regions play pivotal roles in norfloxacin-induced convulsions. biphenylylacetic acid 129-148 interleukin 1 beta Rattus norvegicus 39-47 16824509-11 2006 The results suggest that the increased IL-1beta expressions in the prefrontal cortex and hippocampus induced by norfloxacin with biphenylacetic acid relate to seizure activities, and that these brain regions play pivotal roles in norfloxacin-induced convulsions. Norfloxacin 230-241 interleukin 1 beta Rattus norvegicus 39-47 16830232-5 2006 Exposure of INS cells to interleukin-1beta (IL-1beta; 600 pM; 48 h) resulted in a marked increase in nitric oxide (NO) release with concomitant reduction in the degree of expression, the CML and the catalytic activity of only PP4, but not PP2A, in the nuclear fraction. Nitric Oxide 101-113 interleukin 1 beta Rattus norvegicus 25-42 16830232-5 2006 Exposure of INS cells to interleukin-1beta (IL-1beta; 600 pM; 48 h) resulted in a marked increase in nitric oxide (NO) release with concomitant reduction in the degree of expression, the CML and the catalytic activity of only PP4, but not PP2A, in the nuclear fraction. Nitric Oxide 101-113 interleukin 1 beta Rattus norvegicus 44-52 16718462-9 2006 RESULTS: Pre-exposure of INS-1E cells to the FGFR-inhibitor SU5402, but not to the Src-inhibitor PP2, dose-dependently inhibited IL-1beta-mediated MAPK activity. SU 5402 60-66 interleukin 1 beta Rattus norvegicus 129-137 16838118-0 2006 Hyperbaric oxygenation ameliorates indomethacin-induced enteropathy in rats by modulating TNF-alpha and IL-1beta production. Indomethacin 35-47 interleukin 1 beta Rattus norvegicus 104-112 16838118-8 2006 Indomethacin increased MPO activity and iNOS expression, and these were reduced by HBO2 treatment, with a concomitant reduction in TNF-alpha and IL-1beta. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 145-153 16838118-9 2006 Our data suggest that HBO2 treatment has a beneficial effect on indomethacin-induced enteropathy and this effect is possibly mediated by decreased production of TNF-alpha and IL-1beta. Indomethacin 64-76 interleukin 1 beta Rattus norvegicus 175-183 16785328-7 2006 Intrarenal injection of phenol raised BP, NE secretion from the PH, renal sympathetic nerve activity, and the abundance of reduced nicotinamide-adenine dinucleotide phosphate and reduced the abundance of interleukin-1beta and neural-NO synthase mRNA in the PH, paraventricular nuclei, and locus coeruleus compared with control rats. Phenol 24-30 interleukin 1 beta Rattus norvegicus 204-221 16759642-7 2006 Also, the level of pancreatic proinflammatory cytokine (interleukin-1beta (IL-1beta)) was significantly reduced when rats were treated with rolipram prior cerulein injection (P<0.05). Rolipram 140-148 interleukin 1 beta Rattus norvegicus 56-73 16939916-10 2006 CONCLUSION: PGE(1) can protect against ischemia-reperfusion injury of the rat liver partially by suppressing KCs activation, reducing excessive release of TNF-alpha and IL-1beta from KCs and decreasing the high expression of MCP-1 protein and mRNA. Prostaglandins E 12-15 interleukin 1 beta Rattus norvegicus 169-177 16878024-1 2006 During hepatic ischemia/reperfusion (I/R), proinflammatory cytokines such as tumor necrosis factor alpha and interleukin (IL) 1beta stimulate the induction of inducible nitric oxide synthase (iNOS) in hepatocytes, followed by massive production of nitric oxide. Nitric Oxide 169-181 interleukin 1 beta Rattus norvegicus 109-131 16878024-6 2006 Hepatocytes isolated from rats with I/R markedly increased the production of nitric oxide when stimulated by IL-1beta as compared with sham control. Nitric Oxide 77-89 interleukin 1 beta Rattus norvegicus 109-117 16784727-8 2006 IL-1beta also induced prolonged elevations of hypothalamic microdialysate NE, as well as plasma ACTH and corticosterone. Corticosterone 105-119 interleukin 1 beta Rattus norvegicus 0-8 16784727-15 2006 However, IL-1beta can also exert direct effects on IL-1 receptors on cerebral blood vessels, activating cyclooxygenases and hence synthesis of prostaglandins which in turn can affect body temperature, behavior and HPA axis activation. Prostaglandins 143-157 interleukin 1 beta Rattus norvegicus 9-17 16720054-6 2006 GLP-1 prevented the LPS-induced IL-1beta mRNA expression, which effect was, in turn, inhibited by pretreatment with SQ22536, an adenylate cyclase inhibitor. 9-(tetrahydro-2-furyl)-adenine 116-123 interleukin 1 beta Rattus norvegicus 32-40 16759642-7 2006 Also, the level of pancreatic proinflammatory cytokine (interleukin-1beta (IL-1beta)) was significantly reduced when rats were treated with rolipram prior cerulein injection (P<0.05). Rolipram 140-148 interleukin 1 beta Rattus norvegicus 75-83 16865774-12 2006 In rat insulinoma RINm5F cells, CCE completely protected against interleukin-1beta and interferon-gamma-mediated cytotoxicity. Carbamylcholine 32-35 interleukin 1 beta Rattus norvegicus 65-82 16865774-13 2006 Moreover, RINm5F cells incubated with CCE showed significant reductions in interleukin-1beta and interferon-gamma-induced nitric oxide production and in iNOS mRNA and protein expression, and these findings correlated well with in vivo observations. Carbamylcholine 38-41 interleukin 1 beta Rattus norvegicus 75-92 16886979-8 2006 RESULTS: Caspase-1 inhibition reduced the release of IL-1beta in organotypic slices exposed to LPS+ATP. Adenosine Triphosphate 99-102 interleukin 1 beta Rattus norvegicus 53-61 16765325-6 2006 The pressor response to IL-1beta was abolished by losartan but not by V1ANT. Losartan 50-58 interleukin 1 beta Rattus norvegicus 24-32 16707097-0 2006 Hydrogen sulfide potentiates interleukin-1beta-induced nitric oxide production via enhancement of extracellular signal-regulated kinase activation in rat vascular smooth muscle cells. Hydrogen Sulfide 0-16 interleukin 1 beta Rattus norvegicus 29-46 16707097-0 2006 Hydrogen sulfide potentiates interleukin-1beta-induced nitric oxide production via enhancement of extracellular signal-regulated kinase activation in rat vascular smooth muscle cells. Nitric Oxide 55-67 interleukin 1 beta Rattus norvegicus 29-46 16707097-3 2006 In this study, we investigated whether H(2)S could affect NO production in rat vascular smooth muscle cells (VSMCs) stimulated with interleukin-1beta (IL-1beta). Hydrogen Sulfide 39-44 interleukin 1 beta Rattus norvegicus 132-149 16707097-3 2006 In this study, we investigated whether H(2)S could affect NO production in rat vascular smooth muscle cells (VSMCs) stimulated with interleukin-1beta (IL-1beta). Hydrogen Sulfide 39-44 interleukin 1 beta Rattus norvegicus 151-159 16879498-9 2006 5 Circulating plasma levels of TNF-alpha/IL-1beta were augmented in bleomycin-exposed rats compared with controls. Bleomycin 68-77 interleukin 1 beta Rattus norvegicus 41-49 16879498-10 2006 Tissue incubation with TNF-alpha (100 ng ml(-1))/IL-1beta (10 ng ml(-1)) increased in vitro tracheal responsiveness to carbachol. Carbachol 119-128 interleukin 1 beta Rattus norvegicus 49-57 16751791-18 2006 In conclusion, LPC dose and time dependently reduces the organ injury and circulating IL-1beta levels caused by gram-negative or gram-positive shock in the rat. Lysophosphatidylcholines 15-18 interleukin 1 beta Rattus norvegicus 86-94 16786153-7 2006 Furthermore, after exposure to TMT and LPS, the levels of tumor necrosis factor-alpha and interleukin-1beta were also increased in astrocyte cultures, suggesting that the PAR-1 upregulation we have detected may be involved in glial inflammatory response rather than in cell death. trimethyltin 31-34 interleukin 1 beta Rattus norvegicus 90-107 16805812-7 2006 The NMDA receptor antagonist dizolcipine (MK-801) attenuated cell death induced by low doses of IL-1beta but the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) had no effect. dizolcipine 29-40 interleukin 1 beta Rattus norvegicus 96-104 16805812-7 2006 The NMDA receptor antagonist dizolcipine (MK-801) attenuated cell death induced by low doses of IL-1beta but the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) had no effect. Dizocilpine Maleate 42-48 interleukin 1 beta Rattus norvegicus 96-104 16858290-7 2006 Pretreatment with gadolinium chloride to deplete Kupffer cells before IR: 1) blocked the increase in serum bile acids, 2) attenuated TNFalpha but not IL1beta/IL6 levels, 3) inhibited the altered hepatic transporter expression, and 4) blocked the decrease in HNF1alpha nuclear protein levels. gadolinium chloride 18-37 interleukin 1 beta Rattus norvegicus 150-157 16797507-3 2006 A significant increase in vascular permeability, NOS-2 activity, TNF-alpha, IL-1beta levels and oxidative damage were noted in aspirin administered rats. Aspirin 127-134 interleukin 1 beta Rattus norvegicus 76-84 16580131-3 2006 LPS-inducible IL-1beta was significantly suppressed by pretreatment with the nuclear factor kappa B (NFkappaB) inhibitor ammonium pyrrolidine dithiocarbamate (APDC), but TNFalpha was not. pyrrolidine dithiocarbamic acid 121-157 interleukin 1 beta Rattus norvegicus 14-22 16580131-3 2006 LPS-inducible IL-1beta was significantly suppressed by pretreatment with the nuclear factor kappa B (NFkappaB) inhibitor ammonium pyrrolidine dithiocarbamate (APDC), but TNFalpha was not. pyrrolidine dithiocarbamic acid 159-163 interleukin 1 beta Rattus norvegicus 14-22 16810004-9 2006 Bupivacaine was effective in suppressing systemic tumor necrosis factor alpha and interleukin 1beta by all three routes, whereas tetrodotoxin was ineffective by all three routes. Bupivacaine 0-11 interleukin 1 beta Rattus norvegicus 82-99 16810005-6 2006 RESULTS: Carrageenan-induced hind paw inflammation enhanced tumor necrosis factor-alpha and interleukin-1beta production in bilateral DRGs and spinal cord and enhanced p38 MAPK activation in bilateral DRGs. Carrageenan 9-20 interleukin 1 beta Rattus norvegicus 92-109 16723252-8 2006 CONCLUSIONS: These findings suggested that (1) p38 MAP kinase activation is one of the important aspects of the signaling event that mediate the release of TNF-alpha and IL-1beta and contributes to CPB-induced pulmonary inflammatory response, (2) SB203580 selectively inhibiting p38 MAP kinase activation efficaciously reduces pulmonary inflammatory response after CPB, and (3) p38 MAP kinase influence the activation of NF-kappaB in the lung during and after CPB. SB 203580 247-255 interleukin 1 beta Rattus norvegicus 170-178 16886979-9 2006 Administration of pralnacasan (intracerebroventricular, 50 microg) or VX-765 (intraperitoneal, 25-200 mg/kg) to rats blocked seizure-induced production of IL-1beta in the hippocampus, and resulted in a twofold delay in seizure onset and 50% reduction in seizure duration. pralnacasan 18-29 interleukin 1 beta Rattus norvegicus 155-163 16886979-9 2006 Administration of pralnacasan (intracerebroventricular, 50 microg) or VX-765 (intraperitoneal, 25-200 mg/kg) to rats blocked seizure-induced production of IL-1beta in the hippocampus, and resulted in a twofold delay in seizure onset and 50% reduction in seizure duration. belnacasan 70-76 interleukin 1 beta Rattus norvegicus 155-163 16436473-5 2006 Stimulation with IL-1beta activated PKC-alpha and -delta, which was blocked using the PLC inhibitor U-73122. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 100-107 interleukin 1 beta Rattus norvegicus 17-25 16754540-10 2006 NAC was shown to prevent intracellular GSH depletion and silica-induced production of IL-1beta and TNF-alpha but not apoptosis in AM from silica-exposed rats. Acetylcysteine 0-3 interleukin 1 beta Rattus norvegicus 86-94 16754540-10 2006 NAC was shown to prevent intracellular GSH depletion and silica-induced production of IL-1beta and TNF-alpha but not apoptosis in AM from silica-exposed rats. Silicon Dioxide 57-63 interleukin 1 beta Rattus norvegicus 86-94 16844207-0 2006 Lipopolysaccharide and interleukin-1beta decrease sucrose intake but do not affect expression of place preference in rats. Sucrose 50-57 interleukin 1 beta Rattus norvegicus 23-40 16844207-4 2006 Using a conditioned place preference procedure, the effects of LPS and interleukin-1beta (IL-1beta) on sucrose intake (primary reinforcer) and preference for a sucrose-paired environment (conditioned reinforcer) were tested. Sucrose 103-110 interleukin 1 beta Rattus norvegicus 71-88 16844207-4 2006 Using a conditioned place preference procedure, the effects of LPS and interleukin-1beta (IL-1beta) on sucrose intake (primary reinforcer) and preference for a sucrose-paired environment (conditioned reinforcer) were tested. Sucrose 103-110 interleukin 1 beta Rattus norvegicus 90-98 16844207-5 2006 LPS and IL-1beta decreased sucrose intake but had no effect on the expression of a sucrose-induced place preference, indicating a differential effect of immune system activation on appetitive behaviors maintained by primary and conditioned reinforcers. Sucrose 27-34 interleukin 1 beta Rattus norvegicus 8-16 16603549-2 2006 Treatment of the rat gastric epithelial cell line RGM1 with transforming growth factor-alpha and interleukin-1beta leads to synergistic release of arachidonate and production of prostaglandin E(2). Arachidonic Acid 147-159 interleukin 1 beta Rattus norvegicus 97-114 16603549-2 2006 Treatment of the rat gastric epithelial cell line RGM1 with transforming growth factor-alpha and interleukin-1beta leads to synergistic release of arachidonate and production of prostaglandin E(2). Prostaglandins E 178-193 interleukin 1 beta Rattus norvegicus 97-114 16452158-9 2006 Like iNOS, DTF also inhibited IL-1beta-induced expression of proinflammatory mediators involved in joint inflammation. dtf 11-14 interleukin 1 beta Rattus norvegicus 30-38 16804126-0 2006 Crocetin inhibits mRNA expression for tumor necrosis factor-alpha, interleukin-1beta, and inducible nitric oxide synthase in hemorrhagic shock. crocetin 0-8 interleukin 1 beta Rattus norvegicus 67-84 16804126-3 2006 The hypothesis of the present study is that treatment with crocetin at the beginning of resuscitation suppresses subsequent expression of messenger ribonucleic acid (mRNA) for tumor necrosis factor (TNF-alpha), interleukin-1 (IL-1beta) and inducible nitric oxide synthase (iNOS). crocetin 59-67 interleukin 1 beta Rattus norvegicus 226-234 16458462-13 2006 Paeonol suppresses and scavenges superoxide anion, and inhibit microglia activation and IL-1beta in ischemia-reperfusion injured rats. paeonol 0-7 interleukin 1 beta Rattus norvegicus 88-96 16452158-7 2006 DTF strongly repressed IL-1beta-dependent iNOS induction in a magnitude-dependent manner. dtf 0-3 interleukin 1 beta Rattus norvegicus 23-31 16452158-8 2006 Exposure to 15% DTF resulted in >90% suppression of IL-1beta-induced mRNA within 4 h and this suppression was sustained for the ensuing 20 h. The mechanosensitivity of fibrochondrocytes was also frequency dependent and maximal suppression of iNOS mRNA expression was observed at rapid frequencies of DTF compared with lower frequencies. dtf 16-19 interleukin 1 beta Rattus norvegicus 55-63 16452158-8 2006 Exposure to 15% DTF resulted in >90% suppression of IL-1beta-induced mRNA within 4 h and this suppression was sustained for the ensuing 20 h. The mechanosensitivity of fibrochondrocytes was also frequency dependent and maximal suppression of iNOS mRNA expression was observed at rapid frequencies of DTF compared with lower frequencies. dtf 303-306 interleukin 1 beta Rattus norvegicus 55-63 16731157-9 2006 Pravastatin resulted in significant decreases in the serum levels of interleukin 1beta and tumor necrosis factor-alpha, and also in the infiltration of CD45-positive cells, but not CD117-positive stem cells, in infarcted myocardium. Pravastatin 0-11 interleukin 1 beta Rattus norvegicus 69-118 16685427-11 2006 Inhalation of desflurane during endotoxemia showed a significant decrease in release of the proinflammatory cytokines TNF-alpha (-61%, P< or =0.05) and IL-1beta (-47%, P< or =0.05) in plasma as compared to LPS-only group, whereas the release of IL-6 was not significantly affected by desflurane. Desflurane 14-24 interleukin 1 beta Rattus norvegicus 155-163 16501068-9 2006 In addition, SC-409 inhibited SCW-stimulated expression of numerous factors, including TNF-alpha, interleukin-1beta, and RANKL. sc-409 13-19 interleukin 1 beta Rattus norvegicus 98-115 16293679-7 2006 The effects of IL-1beta were inhibited by Na-salicylate, an inhibitor of cyclooxygenase. na-salicylate 42-55 interleukin 1 beta Rattus norvegicus 15-23 16778360-2 2006 IL-1beta mRNA induction by CA-G alpha13 was suppressed by diphenyleneiodonium (DPI), an NADPH oxidase inhibitor, but not by BAPTA-AM, an intracellular Ca2+ chelator. diphenyleneiodonium 58-77 interleukin 1 beta Rattus norvegicus 0-8 16778360-2 2006 IL-1beta mRNA induction by CA-G alpha13 was suppressed by diphenyleneiodonium (DPI), an NADPH oxidase inhibitor, but not by BAPTA-AM, an intracellular Ca2+ chelator. diphenyleneiodonium 79-82 interleukin 1 beta Rattus norvegicus 0-8 16631733-2 2006 The aim was to determine whether high glucose levels interfere with nitric oxide (NO) production and inducible NO synthase (iNOS) protein expression in interleukin-1beta-stimulated vascular smooth muscle cells from normotensive Wistar Kyoto and spontaneously hypertensive rats. Glucose 38-45 interleukin 1 beta Rattus norvegicus 152-169 16545775-9 2006 Furthermore, fluoxetine treatment significantly inhibited the induction of proinflammatory factor IL-1beta, IL-6, and TNF-alpha in the culture medium of LPS-treated NSCs (p<0.01). Fluoxetine 13-23 interleukin 1 beta Rattus norvegicus 98-106 16293679-8 2006 Moreover, the effects of IL-1beta were mimicked and occluded by PGE2, and were inhibited by AH-23848, an antagonist of the PGE2 type 4 (i.e., EP4) receptor. Dinoprostone 64-68 interleukin 1 beta Rattus norvegicus 25-33 16293679-8 2006 Moreover, the effects of IL-1beta were mimicked and occluded by PGE2, and were inhibited by AH-23848, an antagonist of the PGE2 type 4 (i.e., EP4) receptor. AH 23848 92-100 interleukin 1 beta Rattus norvegicus 25-33 16293679-8 2006 Moreover, the effects of IL-1beta were mimicked and occluded by PGE2, and were inhibited by AH-23848, an antagonist of the PGE2 type 4 (i.e., EP4) receptor. Dinoprostone 123-127 interleukin 1 beta Rattus norvegicus 25-33 16293679-9 2006 The current evoked by IL-1beta was also abolished by 100 microM gadolinium (Gd3+), but was significantly larger when examined in cells preshrunk by negative pressure applied via the recording pipette. Gadolinium 64-74 interleukin 1 beta Rattus norvegicus 22-30 16293679-9 2006 The current evoked by IL-1beta was also abolished by 100 microM gadolinium (Gd3+), but was significantly larger when examined in cells preshrunk by negative pressure applied via the recording pipette. ganglioside, GD3 76-80 interleukin 1 beta Rattus norvegicus 22-30 16293679-11 2006 We conclude that IL-1beta directly excites MNCs via an IL-1R1-mediated induction of PGE2 synthesis and EP4 receptor-dependent autocrine upregulation of the nonselective cation conductance that underlies osmoreception. Dinoprostone 84-88 interleukin 1 beta Rattus norvegicus 17-25 16528573-11 2006 IL-1beta-induced nitric oxide production and decreases in insulin content and secretion were reduced by GADD45beta. Nitric Oxide 17-29 interleukin 1 beta Rattus norvegicus 0-8 16624280-0 2006 Cinnamaldehyde reduces IL-1beta-induced cyclooxygenase-2 activity in rat cerebral microvascular endothelial cells. cinnamaldehyde 0-14 interleukin 1 beta Rattus norvegicus 23-31 16624280-8 2006 IL-1beta increased the mRNA expression and activity of COX-2, and production of PGE(2) in a dose- and time-dependent manner in RCMEC, while mRNA and activity of COX-1 were not significantly altered. Dinoprostone 80-86 interleukin 1 beta Rattus norvegicus 0-8 16624280-9 2006 Cinnamaldehyde significantly decreased IL-1beta-induced COX-2 activity and PGE(2) production in a dose-dependent manner, while it showed no inhibitory effect on IL-1beta-induced COX-2 mRNA expression in cultured RCMEC. cinnamaldehyde 0-14 interleukin 1 beta Rattus norvegicus 39-47 16624280-9 2006 Cinnamaldehyde significantly decreased IL-1beta-induced COX-2 activity and PGE(2) production in a dose-dependent manner, while it showed no inhibitory effect on IL-1beta-induced COX-2 mRNA expression in cultured RCMEC. Dinoprostone 75-81 interleukin 1 beta Rattus norvegicus 39-47 16624280-10 2006 In conclusion, cinnamaldehyde reduces IL-1beta-induced COX-2 activity, but not IL-1beta-induced COX-2 mRNA expression, and consequently inhibits production of PGE(2) in cultured RCMEC. cinnamaldehyde 15-29 interleukin 1 beta Rattus norvegicus 38-46 16557150-13 2006 Treatment with insulin or TDZD-8 reduced the plasma levels of the proinflammatory cytokine interleukin-1beta. 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione 26-32 interleukin 1 beta Rattus norvegicus 91-108 16644698-5 2006 IL-1beta alone induced a strong inhibition of insulin secretion and glucose oxidation rate and a marked increase in medium nitrite accumulation as an indicator of nitric oxide generation. Nitrites 123-130 interleukin 1 beta Rattus norvegicus 0-8 16644698-5 2006 IL-1beta alone induced a strong inhibition of insulin secretion and glucose oxidation rate and a marked increase in medium nitrite accumulation as an indicator of nitric oxide generation. Nitric Oxide 163-175 interleukin 1 beta Rattus norvegicus 0-8 16671873-1 2006 BACKGROUND: In this study, we evaluated the effects of two different regimes of dietary supplementation of omega-3 fatty acid on serum levels of interleukin-1 beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Fatty Acids, Omega-3 107-125 interleukin 1 beta Rattus norvegicus 145-163 16671873-1 2006 BACKGROUND: In this study, we evaluated the effects of two different regimes of dietary supplementation of omega-3 fatty acid on serum levels of interleukin-1 beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Fatty Acids, Omega-3 107-125 interleukin 1 beta Rattus norvegicus 165-173 29539164-1 2006 BACKGROUND: In this study, we evaluated the effects of two different regimes of dietary supplementation of omega-3 fatty acid on serum levels of interleukin-1 beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Fatty Acids, Omega-3 107-125 interleukin 1 beta Rattus norvegicus 145-163 16419088-6 2006 Production of IL-1beta was significantly decreased in vitamin E-treated microglia in vitro. Vitamin E 54-63 interleukin 1 beta Rattus norvegicus 14-22 29539164-1 2006 BACKGROUND: In this study, we evaluated the effects of two different regimes of dietary supplementation of omega-3 fatty acid on serum levels of interleukin-1 beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Fatty Acids, Omega-3 107-125 interleukin 1 beta Rattus norvegicus 165-173 16403660-7 2006 Treatment of myocytes with IL-1beta, TNF-alpha, and IFN-gamma induced a significant increase in the formation of peroxynitrite, and a pretreatment with catalase was found to quench the production of peroxynitrite. Peroxynitrous Acid 113-126 interleukin 1 beta Rattus norvegicus 27-35 16403660-7 2006 Treatment of myocytes with IL-1beta, TNF-alpha, and IFN-gamma induced a significant increase in the formation of peroxynitrite, and a pretreatment with catalase was found to quench the production of peroxynitrite. Peroxynitrous Acid 199-212 interleukin 1 beta Rattus norvegicus 27-35 16480888-1 2006 We investigated the effects of simvastatin treatment on the expression of IL-1beta and MCP-1, the activity of NF-kB, and the signaling pathways related to NF-kB activation in a rat model of permanent middle cerebral artery occlusion (pMCAO). Simvastatin 31-42 interleukin 1 beta Rattus norvegicus 74-82 16480888-2 2006 IL-1beta and MCP-1 expression, determined using RT-PCR, was enhanced by pMCAO; this effect was inhibited by the administration of simvastatin before ischemia. Simvastatin 130-141 interleukin 1 beta Rattus norvegicus 0-8 16701099-12 2006 Serum levels of TNFalpha and IL-1beta showed a significant decrease in the ONO-4817 group, compared with the vehicle group after reperfusion. N-hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide 75-83 interleukin 1 beta Rattus norvegicus 29-37 16299053-6 2006 Incubation of rPASMC with IL-1beta and tumor necrosis factor-alpha induced PDE4B gene expression, an effect that was inhibited by l-N(6)-(1-iminoethyl)lysine, an antagonist of NO synthase 2 (NOS2). N(6)-(1-iminoethyl)lysine 130-157 interleukin 1 beta Rattus norvegicus 26-66 16713284-8 2006 Moreover, incubation of splenocytes with rIL-1beta induced a rapid tyrosine phosphorylation of a 24 kDa polypeptide in both species. Tyrosine 67-75 interleukin 1 beta Rattus norvegicus 41-50 16371439-13 2006 IL-1beta activated ERK, and PD-98059, a MEK1 inhibitor, blocked IL-1beta enhancement of TGF-beta(1) expression and secretion by PSCs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 28-36 interleukin 1 beta Rattus norvegicus 64-72 16584347-15 2006 However, the failure to observe any significant inhibition of bone loss in celecoxib- and/or omega-3 fatty acid-treated rats compared to the LPS group suggests that their therapeutic effect may be reduced by other factors, such as increases in serum IL-1beta promoting osteoclast activity. Celecoxib 75-84 interleukin 1 beta Rattus norvegicus 250-258 16294327-8 2006 Curcumin inhibited platelet-derived growth factor (PDGF)-induced proliferation, alpha-smooth muscle actin gene expression, interleukin-1beta- and tumor necrosis factor (TNF)-alpha-induced MCP-1 production, type I collagen production, and expression of type I and type III collagen genes. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 123-140 16294327-10 2006 Curcumin inhibited interleukin-1beta- and TNF-alpha-induced activation of activator protein-1 (AP-1) and mitogen-activated protein (MAP) kinases (ERK, c-Jun N-terminal kinase (JNK), and p38 MAP kinase), but not of nuclear factor-kappaB (NF-kappaB). Curcumin 0-8 interleukin 1 beta Rattus norvegicus 19-36 16386803-0 2006 The involvement of norepinephrine and microglia in hypothalamic and splenic IL-1beta responses to stress. Norepinephrine 19-33 interleukin 1 beta Rattus norvegicus 76-84 16386803-3 2006 One goal of the following studies was to assess the role of norepinephrine in stress-elicited increases in IL-1beta. Norepinephrine 60-74 interleukin 1 beta Rattus norvegicus 107-115 16386803-6 2006 We found that propranolol blocked the IL-1beta response to footshock in both the hypothalamus and the spleen, while the noradrenergic reuptake inhibitor desipramine significantly augmented the footshock-induced IL-1beta response in both of these sites. Propranolol 14-25 interleukin 1 beta Rattus norvegicus 38-46 16386803-6 2006 We found that propranolol blocked the IL-1beta response to footshock in both the hypothalamus and the spleen, while the noradrenergic reuptake inhibitor desipramine significantly augmented the footshock-induced IL-1beta response in both of these sites. Desipramine 153-164 interleukin 1 beta Rattus norvegicus 211-219 29539151-1 2006 BACKGROUND: The aim of this study was to evaluate the effects of selective cyclooxygenase-2 inhibitor, celecoxib, and omega-3 fatty acid on serum levels of interleukin 1-beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Celecoxib 103-112 interleukin 1 beta Rattus norvegicus 156-174 29539151-1 2006 BACKGROUND: The aim of this study was to evaluate the effects of selective cyclooxygenase-2 inhibitor, celecoxib, and omega-3 fatty acid on serum levels of interleukin 1-beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Fatty Acids, Omega-3 118-136 interleukin 1 beta Rattus norvegicus 156-174 16584347-0 2006 Effects of selective cyclooxygenase-2 inhibitor and omega-3 fatty acid on serum interleukin-1beta, osteocalcin, and C-reactive protein levels in rats. Fatty Acids, Omega-3 52-70 interleukin 1 beta Rattus norvegicus 80-97 16584347-1 2006 BACKGROUND: The aim of this study was to evaluate the effects of selective cyclooxygenase-2 inhibitor, celecoxib, and omega-3 fatty acid on serum levels of interleukin 1-beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Celecoxib 103-112 interleukin 1 beta Rattus norvegicus 156-174 16584347-1 2006 BACKGROUND: The aim of this study was to evaluate the effects of selective cyclooxygenase-2 inhibitor, celecoxib, and omega-3 fatty acid on serum levels of interleukin 1-beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Fatty Acids, Omega-3 118-136 interleukin 1 beta Rattus norvegicus 156-174 16584347-1 2006 BACKGROUND: The aim of this study was to evaluate the effects of selective cyclooxygenase-2 inhibitor, celecoxib, and omega-3 fatty acid on serum levels of interleukin 1-beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Fatty Acids, Omega-3 118-136 interleukin 1 beta Rattus norvegicus 176-184 16584347-10 2006 Omega-3 fatty acid, both alone and in combination with celecoxib, revealed significantly higher IL-1beta levels than LPS and celecoxib groups (P <0.05). Fatty Acids, Omega-3 0-18 interleukin 1 beta Rattus norvegicus 96-104 16584347-10 2006 Omega-3 fatty acid, both alone and in combination with celecoxib, revealed significantly higher IL-1beta levels than LPS and celecoxib groups (P <0.05). Celecoxib 55-64 interleukin 1 beta Rattus norvegicus 96-104 29539151-1 2006 BACKGROUND: The aim of this study was to evaluate the effects of selective cyclooxygenase-2 inhibitor, celecoxib, and omega-3 fatty acid on serum levels of interleukin 1-beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis. Fatty Acids, Omega-3 118-136 interleukin 1 beta Rattus norvegicus 176-184 29539151-10 2006 Omega-3 fatty acid, both alone and in combination with celecoxib, revealed significantly higher IL-1beta levels than LPS and celecoxib groups (P <0.05). Fatty Acids, Omega-3 0-18 interleukin 1 beta Rattus norvegicus 96-104 29539151-10 2006 Omega-3 fatty acid, both alone and in combination with celecoxib, revealed significantly higher IL-1beta levels than LPS and celecoxib groups (P <0.05). Celecoxib 55-64 interleukin 1 beta Rattus norvegicus 96-104 29539151-15 2006 However, the failure to observe any significant inhibition of bone loss in celecoxib- and/or omega-3 fatty acid-treated rats compared to the LPS group suggests that their therapeutic effect may be reduced by other factors, such as increases in serum IL-1beta promoting osteoclast activity. Celecoxib 75-84 interleukin 1 beta Rattus norvegicus 250-258 29539151-15 2006 However, the failure to observe any significant inhibition of bone loss in celecoxib- and/or omega-3 fatty acid-treated rats compared to the LPS group suggests that their therapeutic effect may be reduced by other factors, such as increases in serum IL-1beta promoting osteoclast activity. Fatty Acids, Omega-3 93-111 interleukin 1 beta Rattus norvegicus 250-258 16584347-15 2006 However, the failure to observe any significant inhibition of bone loss in celecoxib- and/or omega-3 fatty acid-treated rats compared to the LPS group suggests that their therapeutic effect may be reduced by other factors, such as increases in serum IL-1beta promoting osteoclast activity. Fatty Acids, Omega-3 93-111 interleukin 1 beta Rattus norvegicus 250-258 16375968-0 2006 Inhibition of water intake by the central administration of IL-1beta in rats: role of the central opioid system. Water 14-19 interleukin 1 beta Rattus norvegicus 60-68 16583240-0 2006 Effect of chronic treatment with perazine on lipopolysaccharide-induced interleukin-1 beta levels in the rat brain. Perazine 33-41 interleukin 1 beta Rattus norvegicus 72-90 16583240-1 2006 In the present study, we sought to determine whether chronic treatment with perazine alters lipopolysaccharide (LPS)-induced interleukin-1 beta (IL-1 beta) levels in the following rat brain regions: the hypothalamus, frontal cortex, striatum and hippocampus. Perazine 76-84 interleukin 1 beta Rattus norvegicus 125-143 16583240-1 2006 In the present study, we sought to determine whether chronic treatment with perazine alters lipopolysaccharide (LPS)-induced interleukin-1 beta (IL-1 beta) levels in the following rat brain regions: the hypothalamus, frontal cortex, striatum and hippocampus. Perazine 76-84 interleukin 1 beta Rattus norvegicus 145-154 16583240-7 2006 Treatment with perazine (30 mg/kg/day) reduced LPS-stimulated IL-1 beta levels in the hypothalamus, and a tendency to its decrease in the striatum and frontal cortex was observed. Perazine 15-23 interleukin 1 beta Rattus norvegicus 62-71 16583240-8 2006 This in vivo study suggests for the first time that long-term oral administration of perazine modulates reactivity of cells producing IL-1 beta. Perazine 85-93 interleukin 1 beta Rattus norvegicus 134-143 16375968-2 2006 Central administration of IL-1beta at the doses of 4 and 8 ng reduced water intake in all three conditions studied. Water 70-75 interleukin 1 beta Rattus norvegicus 26-34 16375968-1 2006 In the present study we investigated, the effect of third ventricle injections of IL-1beta on water intake, in rats, induced by three different physiological stimuli: dehydration induced by water deprivation, hypernatremia associated with hyperosmolarity induced by intragastric salt load, and hypovolemia produced by subcutaneous polytethyleneglycol administration. Water 94-99 interleukin 1 beta Rattus norvegicus 82-90 16351573-1 2006 In IL-1beta (interleukin 1beta)-stimulated rat hepatocytes exposed to superoxide, we have previously identified an IRX (inflammatory redox)-sensitive DR1 [direct repeat of RG(G/T)TCA with one base spacing] cis-acting activator element (nt -1327 to -1315) in the iNOS (inducible nitric oxide synthase) promoter: AGGTCAGGGGACA. Trichloroacetic Acid 179-182 interleukin 1 beta Rattus norvegicus 3-11 16351573-1 2006 In IL-1beta (interleukin 1beta)-stimulated rat hepatocytes exposed to superoxide, we have previously identified an IRX (inflammatory redox)-sensitive DR1 [direct repeat of RG(G/T)TCA with one base spacing] cis-acting activator element (nt -1327 to -1315) in the iNOS (inducible nitric oxide synthase) promoter: AGGTCAGGGGACA. Trichloroacetic Acid 179-182 interleukin 1 beta Rattus norvegicus 13-30 16351573-1 2006 In IL-1beta (interleukin 1beta)-stimulated rat hepatocytes exposed to superoxide, we have previously identified an IRX (inflammatory redox)-sensitive DR1 [direct repeat of RG(G/T)TCA with one base spacing] cis-acting activator element (nt -1327 to -1315) in the iNOS (inducible nitric oxide synthase) promoter: AGGTCAGGGGACA. Superoxides 70-80 interleukin 1 beta Rattus norvegicus 3-11 16484541-6 2006 When compared with the T group, the OS group showed decreased anorexia and body weight loss; reduced bowel wall thickening and longitudinal extension of necrotic lesions; downregulated colonic expression of interleukin 1beta, inducible nitric oxide synthase, cyclooxygenase 2, and mucin 3; and increased trefoil factor 3. Osmium 36-38 interleukin 1 beta Rattus norvegicus 207-224 16351573-1 2006 In IL-1beta (interleukin 1beta)-stimulated rat hepatocytes exposed to superoxide, we have previously identified an IRX (inflammatory redox)-sensitive DR1 [direct repeat of RG(G/T)TCA with one base spacing] cis-acting activator element (nt -1327 to -1315) in the iNOS (inducible nitric oxide synthase) promoter: AGGTCAGGGGACA. Superoxides 70-80 interleukin 1 beta Rattus norvegicus 13-30 16553786-7 2006 Accordingly, we tested the effects of the opioid antagonist, naloxone, on oxytocin neuron responses to IL-1beta in pregnancy. Naloxone 61-69 interleukin 1 beta Rattus norvegicus 103-111 16553786-9 2006 did not affect the oxytocin secretory response to IL-1beta in virgin rats, whereas in late pregnant rats naloxone revealed a greater oxytocin secretory response to IL-1beta (3.5-fold) than in virgin rats. Naloxone 105-113 interleukin 1 beta Rattus norvegicus 164-172 16553786-10 2006 In virgin rats, naloxone decreased oxytocin neuron firing rate after IL-1beta, however, in pregnant rats naloxone increased the firing rate response to IL-1beta to the level seen in virgin rats. Naloxone 16-24 interleukin 1 beta Rattus norvegicus 69-77 16553786-10 2006 In virgin rats, naloxone decreased oxytocin neuron firing rate after IL-1beta, however, in pregnant rats naloxone increased the firing rate response to IL-1beta to the level seen in virgin rats. Naloxone 105-113 interleukin 1 beta Rattus norvegicus 152-160 16553786-13 2006 The exaggerated oxytocin secretory response to IL-1beta in pregnancy after naloxone reflects increased oxytocin stores and/or increased efficiency of excitation-secretion coupling at the posterior pituitary. Naloxone 75-83 interleukin 1 beta Rattus norvegicus 47-55 16545059-4 2006 Furthermore, aluminum caused marked elevation in the levels of the glial markers (glial fibrillary acidic protein (GFAP) and S100B) and proinflammatory cytokines (TNF-alpha and IL-1beta) in both brain areas. Aluminum 13-21 interleukin 1 beta Rattus norvegicus 177-185 16169897-6 2006 In both mixed species (human fibroblasts-rat ATII cells) and same species cocultures (rat fibroblasts and ATII cells), PGE2 secretion was inhibited by the presence of IL-1 receptor antagonist (IL-1Ra) or selective neutralizing antibody directed against rat IL-1alpha (but not IL-1beta). Dinoprostone 119-123 interleukin 1 beta Rattus norvegicus 276-284 16438962-5 2006 The IL-1beta-mediated potentiation was partly suppressed by zinc protoporphyrin (3 microM) and was abolished by tetrodotoxin (TTX, 100 nM), (-)-perillic acid (1 microM), PD98059 (0.3 microM), SB203580 (1 microM) and prazosin (1 microM). zinc protoporphyrin 60-79 interleukin 1 beta Rattus norvegicus 4-12 16438962-5 2006 The IL-1beta-mediated potentiation was partly suppressed by zinc protoporphyrin (3 microM) and was abolished by tetrodotoxin (TTX, 100 nM), (-)-perillic acid (1 microM), PD98059 (0.3 microM), SB203580 (1 microM) and prazosin (1 microM). Tetrodotoxin 112-124 interleukin 1 beta Rattus norvegicus 4-12 16438962-5 2006 The IL-1beta-mediated potentiation was partly suppressed by zinc protoporphyrin (3 microM) and was abolished by tetrodotoxin (TTX, 100 nM), (-)-perillic acid (1 microM), PD98059 (0.3 microM), SB203580 (1 microM) and prazosin (1 microM). Tetrodotoxin 126-129 interleukin 1 beta Rattus norvegicus 4-12 16438962-5 2006 The IL-1beta-mediated potentiation was partly suppressed by zinc protoporphyrin (3 microM) and was abolished by tetrodotoxin (TTX, 100 nM), (-)-perillic acid (1 microM), PD98059 (0.3 microM), SB203580 (1 microM) and prazosin (1 microM). perillic acid 140-157 interleukin 1 beta Rattus norvegicus 4-12 16438962-5 2006 The IL-1beta-mediated potentiation was partly suppressed by zinc protoporphyrin (3 microM) and was abolished by tetrodotoxin (TTX, 100 nM), (-)-perillic acid (1 microM), PD98059 (0.3 microM), SB203580 (1 microM) and prazosin (1 microM). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 170-177 interleukin 1 beta Rattus norvegicus 4-12 16438962-5 2006 The IL-1beta-mediated potentiation was partly suppressed by zinc protoporphyrin (3 microM) and was abolished by tetrodotoxin (TTX, 100 nM), (-)-perillic acid (1 microM), PD98059 (0.3 microM), SB203580 (1 microM) and prazosin (1 microM). SB 203580 192-200 interleukin 1 beta Rattus norvegicus 4-12 16438962-5 2006 The IL-1beta-mediated potentiation was partly suppressed by zinc protoporphyrin (3 microM) and was abolished by tetrodotoxin (TTX, 100 nM), (-)-perillic acid (1 microM), PD98059 (0.3 microM), SB203580 (1 microM) and prazosin (1 microM). Prazosin 216-224 interleukin 1 beta Rattus norvegicus 4-12 16438962-6 2006 Our data suggest that IL-1beta (10 ng/ml) causes an enhancement of U46619-mediated basilar artery contraction that probably involves TTX-sensitive neuronal release of an alpha1-adrenoceptor agonist and activation of p42/p44 and p38 mitogen-activated protein kinases/p21(ras) pathways. 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid 67-73 interleukin 1 beta Rattus norvegicus 22-30 16438962-6 2006 Our data suggest that IL-1beta (10 ng/ml) causes an enhancement of U46619-mediated basilar artery contraction that probably involves TTX-sensitive neuronal release of an alpha1-adrenoceptor agonist and activation of p42/p44 and p38 mitogen-activated protein kinases/p21(ras) pathways. Tetrodotoxin 133-136 interleukin 1 beta Rattus norvegicus 22-30 16516485-0 2006 Inhibition of brain nitric oxide synthesis enhances and prolongs the hypertensive effect of centrally administered interleukin-1beta in rats. Nitric Oxide 20-32 interleukin 1 beta Rattus norvegicus 115-132 16516485-1 2006 The present study was designed to find out whether brain nitric oxide (NO) influences hemodynamic response to intracerebroventricular (ICV) infusion of interleukin-1 beta (IL-1beta). Nitric Oxide 57-69 interleukin 1 beta Rattus norvegicus 152-170 16516485-1 2006 The present study was designed to find out whether brain nitric oxide (NO) influences hemodynamic response to intracerebroventricular (ICV) infusion of interleukin-1 beta (IL-1beta). Nitric Oxide 57-69 interleukin 1 beta Rattus norvegicus 172-180 15963243-3 2006 The aim of this study was to evaluate the effect of amitriptyline and its metabolite nortriptyline on the release of IL-1beta and TNF-alpha by lipopolysaccharide (LPS)-activated rat mixed glial and microglial cell cultures. Amitriptyline 52-65 interleukin 1 beta Rattus norvegicus 117-125 16376325-7 2006 IL-1beta downregulated the expression of VLDL-R in a time- and dose-dependent manner and markedly reduced the uptake of DiI-labeled beta-VLDL but not DiI-labeled low-density lipoprotein (LDL). dilC18(3) dye 120-123 interleukin 1 beta Rattus norvegicus 0-8 15963243-5 2006 The exposure of mixed glial culture to amitriptyline and nortriptyline led to a decrease in both IL-1beta and TNF-alpha release. Nortriptyline 57-70 interleukin 1 beta Rattus norvegicus 97-105 16049703-0 2006 Triamcinolone acetonide suppresses interleukin-1 beta-mediated increase in vascular endothelial growth factor expression in cultured rat Muller cells. Triamcinolone Acetonide 0-23 interleukin 1 beta Rattus norvegicus 35-53 16049703-3 2006 We investigated the effect of TA on the expression of VEGF mRNA and protein induced by interleukin-1 beta (IL-1b) and hypoxia in cultured rat Muller cells. Triamcinolone Acetonide 30-32 interleukin 1 beta Rattus norvegicus 87-105 16049703-3 2006 We investigated the effect of TA on the expression of VEGF mRNA and protein induced by interleukin-1 beta (IL-1b) and hypoxia in cultured rat Muller cells. Triamcinolone Acetonide 30-32 interleukin 1 beta Rattus norvegicus 107-112 15963243-3 2006 The aim of this study was to evaluate the effect of amitriptyline and its metabolite nortriptyline on the release of IL-1beta and TNF-alpha by lipopolysaccharide (LPS)-activated rat mixed glial and microglial cell cultures. Nortriptyline 85-98 interleukin 1 beta Rattus norvegicus 117-125 15963243-6 2006 Moreover, amitriptyline reduced LPS-stimulated IL-1beta release by microglial cultures. Amitriptyline 10-23 interleukin 1 beta Rattus norvegicus 47-55 15963243-5 2006 The exposure of mixed glial culture to amitriptyline and nortriptyline led to a decrease in both IL-1beta and TNF-alpha release. Amitriptyline 39-52 interleukin 1 beta Rattus norvegicus 97-105 15963243-8 2006 Our study has shown for the first time that amitriptyline and nortriptyline administered at concentrations which may be achieved in plasma and brain structures during treatment, inhibit the secretion of IL-1beta and TNF-alpha in rat mixed glial and microglial cell cultures. Amitriptyline 44-57 interleukin 1 beta Rattus norvegicus 203-211 16427196-0 2006 Peripheral inflammation modifies the effect of intrathecal IL-1beta on spinal PGE2 production mainly through cyclooxygenase-2 activity. Dinoprostone 78-82 interleukin 1 beta Rattus norvegicus 59-67 15963243-8 2006 Our study has shown for the first time that amitriptyline and nortriptyline administered at concentrations which may be achieved in plasma and brain structures during treatment, inhibit the secretion of IL-1beta and TNF-alpha in rat mixed glial and microglial cell cultures. Nortriptyline 62-75 interleukin 1 beta Rattus norvegicus 203-211 16485131-6 2006 Tyrphostin AG126, given intraperitoneally 30 min before ischemia at the dose of 5 mg/kg, significantly improved mean arterial blood pressure, markedly reduced TNF-alpha and IL-1beta levels and the positive staining of ICAM-1 into the reperfused ileum. Tyrphostins 0-10 interleukin 1 beta Rattus norvegicus 173-181 16485131-6 2006 Tyrphostin AG126, given intraperitoneally 30 min before ischemia at the dose of 5 mg/kg, significantly improved mean arterial blood pressure, markedly reduced TNF-alpha and IL-1beta levels and the positive staining of ICAM-1 into the reperfused ileum. AG 127 11-16 interleukin 1 beta Rattus norvegicus 173-181 16427196-7 2006 IL-1beta on spinal PGE(2) production in the absence and presence of peripheral formalin inflammation with spinal microdialysis in freely moving rats. Prostaglandins E 19-22 interleukin 1 beta Rattus norvegicus 0-8 16461476-0 2006 Effects of topical treatment of sodium butyrate and 5-aminosalicylic acid on expression of trefoil factor 3, interleukin 1beta, and nuclear factor kappaB in trinitrobenzene sulphonic acid induced colitis in rats. Butyric Acid 32-47 interleukin 1 beta Rattus norvegicus 109-126 16461476-0 2006 Effects of topical treatment of sodium butyrate and 5-aminosalicylic acid on expression of trefoil factor 3, interleukin 1beta, and nuclear factor kappaB in trinitrobenzene sulphonic acid induced colitis in rats. Mesalamine 52-73 interleukin 1 beta Rattus norvegicus 109-126 16461476-2 2006 This study evaluates effects of topical treatment of sodium butyrate (NaB) and 5-aminosalicylic acid (5-ASA) on the expression of trefoil factor 3 (TFF3), interleukin 1beta (IL1beta), and nuclear factor kappaB (NFkappaB) in trinitrobenzene sulphonic acid (TNBS) induced colitis in rats. Butyric Acid 53-68 interleukin 1 beta Rattus norvegicus 155-172 16461476-2 2006 This study evaluates effects of topical treatment of sodium butyrate (NaB) and 5-aminosalicylic acid (5-ASA) on the expression of trefoil factor 3 (TFF3), interleukin 1beta (IL1beta), and nuclear factor kappaB (NFkappaB) in trinitrobenzene sulphonic acid (TNBS) induced colitis in rats. Butyric Acid 53-68 interleukin 1 beta Rattus norvegicus 174-181 16461476-2 2006 This study evaluates effects of topical treatment of sodium butyrate (NaB) and 5-aminosalicylic acid (5-ASA) on the expression of trefoil factor 3 (TFF3), interleukin 1beta (IL1beta), and nuclear factor kappaB (NFkappaB) in trinitrobenzene sulphonic acid (TNBS) induced colitis in rats. nab 70-73 interleukin 1 beta Rattus norvegicus 155-172 16461476-2 2006 This study evaluates effects of topical treatment of sodium butyrate (NaB) and 5-aminosalicylic acid (5-ASA) on the expression of trefoil factor 3 (TFF3), interleukin 1beta (IL1beta), and nuclear factor kappaB (NFkappaB) in trinitrobenzene sulphonic acid (TNBS) induced colitis in rats. nab 70-73 interleukin 1 beta Rattus norvegicus 174-181 16554088-0 2006 Role of the central opioid system in the inhibition of water and salt intake induced by central administration of IL-1beta in rats. Water 55-60 interleukin 1 beta Rattus norvegicus 114-122 16554088-0 2006 Role of the central opioid system in the inhibition of water and salt intake induced by central administration of IL-1beta in rats. Salts 65-69 interleukin 1 beta Rattus norvegicus 114-122 16554088-1 2006 In the present study we investigated, the effect of third ventricle injections of IL-1beta on water and salt intake in fluid-deprived and sodium-depleted rats. Water 94-99 interleukin 1 beta Rattus norvegicus 82-90 16554088-1 2006 In the present study we investigated, the effect of third ventricle injections of IL-1beta on water and salt intake in fluid-deprived and sodium-depleted rats. Salts 104-108 interleukin 1 beta Rattus norvegicus 82-90 16554088-2 2006 Central administration of IL-1beta significantly reduced water and salt intake in fluid-deprived animals and decreased salt intake in sodium-depleted rats. Water 57-62 interleukin 1 beta Rattus norvegicus 26-34 16461476-2 2006 This study evaluates effects of topical treatment of sodium butyrate (NaB) and 5-aminosalicylic acid (5-ASA) on the expression of trefoil factor 3 (TFF3), interleukin 1beta (IL1beta), and nuclear factor kappaB (NFkappaB) in trinitrobenzene sulphonic acid (TNBS) induced colitis in rats. Mesalamine 79-100 interleukin 1 beta Rattus norvegicus 155-172 16427196-8 2006 The possible involvement of cyclooxygenase (COX) isoforms in the IL-1beta-mediated spinal PGE(2) production on the background of peripheral formalin inflammation was further evaluated with the selective COX-1 and COX-2 inhibitors. Dinoprostone 90-96 interleukin 1 beta Rattus norvegicus 65-73 16461476-2 2006 This study evaluates effects of topical treatment of sodium butyrate (NaB) and 5-aminosalicylic acid (5-ASA) on the expression of trefoil factor 3 (TFF3), interleukin 1beta (IL1beta), and nuclear factor kappaB (NFkappaB) in trinitrobenzene sulphonic acid (TNBS) induced colitis in rats. Mesalamine 102-107 interleukin 1 beta Rattus norvegicus 155-172 16461476-5 2006 RESULTS: Treatment of NaB, 5-ASA, and the combination improved diarrhoea, colonic damage score, and MPO activities, increased TFF3 mRNA expression, and decreased serum IL1beta production and tissue NFkappaB expression. nab 22-25 interleukin 1 beta Rattus norvegicus 168-175 16554088-2 2006 Central administration of IL-1beta significantly reduced water and salt intake in fluid-deprived animals and decreased salt intake in sodium-depleted rats. Salts 67-71 interleukin 1 beta Rattus norvegicus 26-34 16554088-2 2006 Central administration of IL-1beta significantly reduced water and salt intake in fluid-deprived animals and decreased salt intake in sodium-depleted rats. Salts 119-123 interleukin 1 beta Rattus norvegicus 26-34 16427196-8 2006 The possible involvement of cyclooxygenase (COX) isoforms in the IL-1beta-mediated spinal PGE(2) production on the background of peripheral formalin inflammation was further evaluated with the selective COX-1 and COX-2 inhibitors. Formaldehyde 140-148 interleukin 1 beta Rattus norvegicus 65-73 16554088-2 2006 Central administration of IL-1beta significantly reduced water and salt intake in fluid-deprived animals and decreased salt intake in sodium-depleted rats. Sodium 134-140 interleukin 1 beta Rattus norvegicus 26-34 16461476-5 2006 RESULTS: Treatment of NaB, 5-ASA, and the combination improved diarrhoea, colonic damage score, and MPO activities, increased TFF3 mRNA expression, and decreased serum IL1beta production and tissue NFkappaB expression. Mesalamine 27-32 interleukin 1 beta Rattus norvegicus 168-175 16461476-7 2006 CONCLUSIONS: The combination of topical treatment of NaB and 5-ASA was effective for relieving and repairing colonic inflammation and the effects were related to stimulation of TFF3 mRNA expression and down-regulation of IL1beta production and NFkappaB expression. nab 53-56 interleukin 1 beta Rattus norvegicus 221-228 16554088-3 2006 The antidipsogenic and antinatriorexic effects elicited by the central administration of IL-1beta were suppressed by pretreatment with central injections of the non-selective opioid antagonist naloxone (10 mug) in the two different experimental protocols used here (water deprivation and sodium depletion). Naloxone 193-201 interleukin 1 beta Rattus norvegicus 89-97 16427196-10 2006 administration of IL-1beta, with doses of 1, 2, 8, or 16 ng, increased PGE(2) levels in CSF in a dose-related fashion. Dinoprostone 71-77 interleukin 1 beta Rattus norvegicus 18-26 16554088-3 2006 The antidipsogenic and antinatriorexic effects elicited by the central administration of IL-1beta were suppressed by pretreatment with central injections of the non-selective opioid antagonist naloxone (10 mug) in the two different experimental protocols used here (water deprivation and sodium depletion). Sodium 288-294 interleukin 1 beta Rattus norvegicus 89-97 16461476-7 2006 CONCLUSIONS: The combination of topical treatment of NaB and 5-ASA was effective for relieving and repairing colonic inflammation and the effects were related to stimulation of TFF3 mRNA expression and down-regulation of IL1beta production and NFkappaB expression. Mesalamine 61-66 interleukin 1 beta Rattus norvegicus 221-228 16554088-5 2006 The present results suggest that the activation of the central interleukinergic component by IL-1beta impairs the increase in water and salt intake induced by water deprivation and the enhancement in sodium appetite that follows sodium depletion. Water 126-131 interleukin 1 beta Rattus norvegicus 93-101 16427196-12 2006 Peripheral formalin inflammation in the paw induced a more prolonged effect of spinal IL-1beta with larger PGE(2) releases in the CSF compared with the non-inflammatory state, suggesting that peripheral inflammation enhances central sensitization. Formaldehyde 11-19 interleukin 1 beta Rattus norvegicus 86-94 16554088-5 2006 The present results suggest that the activation of the central interleukinergic component by IL-1beta impairs the increase in water and salt intake induced by water deprivation and the enhancement in sodium appetite that follows sodium depletion. Salts 136-140 interleukin 1 beta Rattus norvegicus 93-101 16427196-12 2006 Peripheral formalin inflammation in the paw induced a more prolonged effect of spinal IL-1beta with larger PGE(2) releases in the CSF compared with the non-inflammatory state, suggesting that peripheral inflammation enhances central sensitization. Dinoprostone 107-113 interleukin 1 beta Rattus norvegicus 86-94 16554088-5 2006 The present results suggest that the activation of the central interleukinergic component by IL-1beta impairs the increase in water and salt intake induced by water deprivation and the enhancement in sodium appetite that follows sodium depletion. Sodium 200-206 interleukin 1 beta Rattus norvegicus 93-101 16554088-5 2006 The present results suggest that the activation of the central interleukinergic component by IL-1beta impairs the increase in water and salt intake induced by water deprivation and the enhancement in sodium appetite that follows sodium depletion. Sodium 229-235 interleukin 1 beta Rattus norvegicus 93-101 16427196-13 2006 The COX-2 inhibitor SC58236 (15 mg/kg) reduced the IL-1beta-mediated PGE(2) increase in CSF by 86% while the COX-1 inhibitor SC58560 (15 mg/kg) had less effect (28%). 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide 20-27 interleukin 1 beta Rattus norvegicus 51-59 16427196-13 2006 The COX-2 inhibitor SC58236 (15 mg/kg) reduced the IL-1beta-mediated PGE(2) increase in CSF by 86% while the COX-1 inhibitor SC58560 (15 mg/kg) had less effect (28%). Prostaglandins E 69-72 interleukin 1 beta Rattus norvegicus 51-59 16427196-13 2006 The COX-2 inhibitor SC58236 (15 mg/kg) reduced the IL-1beta-mediated PGE(2) increase in CSF by 86% while the COX-1 inhibitor SC58560 (15 mg/kg) had less effect (28%). SC 58560 125-132 interleukin 1 beta Rattus norvegicus 51-59 16427196-14 2006 Our study suggests that mainly the COX-2 enzyme mediates the IL-1beta-induced increase in spinal PGE(2) in the presence of peripheral formalin inflammation. Prostaglandins E 97-100 interleukin 1 beta Rattus norvegicus 61-69 16427196-14 2006 Our study suggests that mainly the COX-2 enzyme mediates the IL-1beta-induced increase in spinal PGE(2) in the presence of peripheral formalin inflammation. Formaldehyde 134-142 interleukin 1 beta Rattus norvegicus 61-69 16393992-5 2006 IL-1beta and TNF-alpha rapidly stimulated the rate of hydrogen peroxide produced by isolated microglia, and this was inhibited by diphenylene iodonium, implying that the cytokines were acting directly on microglia to stimulate the NADPH oxidase. Hydrogen Peroxide 54-71 interleukin 1 beta Rattus norvegicus 0-8 16461118-7 2006 Moreover, 15d-PGJ2 significantly decreased the cytokine interleukin-1beta in the bladder. 15-deoxy-delta(12,14)-prostaglandin J2 10-18 interleukin 1 beta Rattus norvegicus 56-73 16393992-5 2006 IL-1beta and TNF-alpha rapidly stimulated the rate of hydrogen peroxide produced by isolated microglia, and this was inhibited by diphenylene iodonium, implying that the cytokines were acting directly on microglia to stimulate the NADPH oxidase. diphenyleneiodonium 130-150 interleukin 1 beta Rattus norvegicus 0-8 16393992-8 2006 In conclusion, these findings indicate that microglial proliferation in response to IL-1beta or TNF-alpha is mediated by hydrogen peroxide from NADPH oxidase. Hydrogen Peroxide 121-138 interleukin 1 beta Rattus norvegicus 84-92 16883638-10 2006 IL-1beta increased the production of PGE(2) in a dose- and time-dependent manner. Prostaglandins E 37-40 interleukin 1 beta Rattus norvegicus 0-8 16883638-11 2006 3-Phenyl-2-propene-1-ol significantly decreased IL-1beta-induced PGE(2) release in a dose-dependent manner. cinnamyl alcohol 0-23 interleukin 1 beta Rattus norvegicus 48-56 16883638-0 2006 Effect of 3-Phenyl-2-Propene-1-ol on PGE2 release from rat cerebral microvascular endothelial cells stimulated by IL-1beta. cinnamyl alcohol 10-33 interleukin 1 beta Rattus norvegicus 114-122 16883638-0 2006 Effect of 3-Phenyl-2-Propene-1-ol on PGE2 release from rat cerebral microvascular endothelial cells stimulated by IL-1beta. Dinoprostone 37-41 interleukin 1 beta Rattus norvegicus 114-122 16883638-11 2006 3-Phenyl-2-propene-1-ol significantly decreased IL-1beta-induced PGE(2) release in a dose-dependent manner. Dinoprostone 65-71 interleukin 1 beta Rattus norvegicus 48-56 16883638-4 2006 In the present study, we examined the influence of interleukin-1beta (IL-1beta) on prostaglandin E(2) (PGE(2)) release, and the effect of 3-phenyl-2-propene-1-ol on IL-1beta-induced PGE(2) release from rat cerebral endothelial cells (rCMEC). Prostaglandins E 83-98 interleukin 1 beta Rattus norvegicus 70-78 16883638-12 2006 Our results indicate that 3-phenyl-2-propene-1-ol inhibits the PGE(2) release from rCMEC stimulated by IL-1beta, and may have an antipyretic effect. cinnamyl alcohol 26-49 interleukin 1 beta Rattus norvegicus 103-111 16883638-12 2006 Our results indicate that 3-phenyl-2-propene-1-ol inhibits the PGE(2) release from rCMEC stimulated by IL-1beta, and may have an antipyretic effect. Dinoprostone 63-69 interleukin 1 beta Rattus norvegicus 103-111 16501235-8 2006 Betamethasone may act by regulating the expression of NF-kappaB, TNFalpha, IL-1beta and IL-10 in the brain. Betamethasone 0-13 interleukin 1 beta Rattus norvegicus 75-83 16912428-4 2006 As the stimulated synthesis of PGE2 originates from the preferential coupling of inducible enzymes, cyclooxygenase-2 (COX-2) and membrane PGE synthase-1 (mPGES-1), we investigated the potency of 15d-PGJ2 to regulate prostaglandins synthesis in rat chondrocytes stimulated with interleukin-1beta (IL-1beta). Dinoprostone 31-35 interleukin 1 beta Rattus norvegicus 277-294 16368379-6 2006 Hypoxia-induced upregulation of TNF-alpha and IL-1beta mRNA in pulmonary artery was significantly decreased by tadalafil, but not sildenafil or vardenafil pretreatment. Tadalafil 111-120 interleukin 1 beta Rattus norvegicus 46-54 16501235-6 2006 In addition, betamethasone reduced the activation of NF-kappaB and elevation of TNFalpha and IL-1beta, and induced the expression of IL-10 in the brain, all of which correlated with the changes of pain thresholds in rats. Betamethasone 13-26 interleukin 1 beta Rattus norvegicus 93-101 16378139-9 2006 DETA decreased IL-1beta-induced MMP-9 expression and activity in both RA-SMCs and RAEs in a dose-dependent fashion. DEET 0-4 interleukin 1 beta Rattus norvegicus 15-23 17109745-0 2006 Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta. Glucosamine 10-21 interleukin 1 beta Rattus norvegicus 87-95 17109745-6 2006 Of the 2,813 genes whose transcription was altered by IL-1beta stimulation (P < 0.0001), glucosamine significantly blocked the response in 2,055 (approximately 73%). Glucosamine 92-103 interleukin 1 beta Rattus norvegicus 54-62 17109745-10 2006 They suggest, however, that the potential benefit of glucosamine in osteoarthritis is not related to cartilage matrix biosynthesis, but is more probably related to its ability to globally inhibit the deleterious effects of IL-1beta signaling. Glucosamine 53-64 interleukin 1 beta Rattus norvegicus 223-231 16465047-12 2006 When NAG was used as the osmotic solute instead of GLU, intraperitoneal inflammation in uremic animals was further reduced: TNFalpha (-40%, p < 0.05); IL-1beta (-49%, p < 0.005); MCP-1 (-21%, p < 0.005). Acetylglucosamine 5-8 interleukin 1 beta Rattus norvegicus 154-162 16465047-13 2006 The presence of NAG also reduced the increased blood level of IL-1beta (-47%,p < 0.02) and MCP-1 (-36%, p < 0.02). Acetylglucosamine 16-19 interleukin 1 beta Rattus norvegicus 62-70 16912428-4 2006 As the stimulated synthesis of PGE2 originates from the preferential coupling of inducible enzymes, cyclooxygenase-2 (COX-2) and membrane PGE synthase-1 (mPGES-1), we investigated the potency of 15d-PGJ2 to regulate prostaglandins synthesis in rat chondrocytes stimulated with interleukin-1beta (IL-1beta). Dinoprostone 31-35 interleukin 1 beta Rattus norvegicus 296-304 16501855-9 2006 The gastric contents of MPO, TNF-alpha, IL-1beta, and CRO/CINC-1 were all increased after water-immersion stress and were reduced to almost normal levels by cilostazol. Cilostazol 157-167 interleukin 1 beta Rattus norvegicus 40-48 16038916-6 2006 The inhibitory effect of CTS on the IL-1beta-induced upregulation of RANKL and RANK was sustained as well as magnitude and frequency dependent. castanospermine 25-28 interleukin 1 beta Rattus norvegicus 36-44 16374148-13 2006 mRNA expression of interleukin (IL)-1beta was downregulated by 42.5 +/- 4.7% (p < .05) and transforming growth factor (TGF)-beta1 was upregulated by 11.7 +/- 1.5% (p < .05) in splenocytes obtained 6 hrs postsophorolipid treatment. postsophorolipid 209-225 interleukin 1 beta Rattus norvegicus 19-41 16183707-0 2006 Increased superoxide anion production by interleukin-1beta impairs nitric oxide-mediated relaxation in resistance arteries. Superoxides 10-26 interleukin 1 beta Rattus norvegicus 41-58 17207419-4 2006 RESULTS: Atorvastatin attenuated downregulation of PPARgamma mRNA and inhibited brain natriuretic peptide (BNP), interleukin-1beta (IL-1beta) and matrix metalloproteinase 9 (MMP9) mRNA expression, as well as 3H-leucine incorporation in a dose-dependent manner in vitro. Atorvastatin 9-21 interleukin 1 beta Rattus norvegicus 113-130 17207419-4 2006 RESULTS: Atorvastatin attenuated downregulation of PPARgamma mRNA and inhibited brain natriuretic peptide (BNP), interleukin-1beta (IL-1beta) and matrix metalloproteinase 9 (MMP9) mRNA expression, as well as 3H-leucine incorporation in a dose-dependent manner in vitro. Atorvastatin 9-21 interleukin 1 beta Rattus norvegicus 132-140 16183707-0 2006 Increased superoxide anion production by interleukin-1beta impairs nitric oxide-mediated relaxation in resistance arteries. Nitric Oxide 67-79 interleukin 1 beta Rattus norvegicus 41-58 17207419-5 2006 Furthermore, atorvastatin reduced the mRNA expression of BNP, IL-1beta and MMP9, and enhanced PPARgamma mRNA expression, and diminished the pressure overload-induced increase in the ratio of heart weight to body weight, left ventricular wall thickness and myocyte diameter of rats in vivo. Atorvastatin 13-25 interleukin 1 beta Rattus norvegicus 62-70 16183707-6 2006 IL-1beta impaired acetylcholine (ACh) and sodium nitroprusside (SNP) vasodilation and increased nitrite and O(2)(.) Acetylcholine 18-31 interleukin 1 beta Rattus norvegicus 0-8 16183707-6 2006 IL-1beta impaired acetylcholine (ACh) and sodium nitroprusside (SNP) vasodilation and increased nitrite and O(2)(.) Acetylcholine 33-36 interleukin 1 beta Rattus norvegicus 0-8 16183707-6 2006 IL-1beta impaired acetylcholine (ACh) and sodium nitroprusside (SNP) vasodilation and increased nitrite and O(2)(.) Nitroprusside 42-62 interleukin 1 beta Rattus norvegicus 0-8 16183707-6 2006 IL-1beta impaired acetylcholine (ACh) and sodium nitroprusside (SNP) vasodilation and increased nitrite and O(2)(.) Nitrites 96-103 interleukin 1 beta Rattus norvegicus 0-8 16183707-6 2006 IL-1beta impaired acetylcholine (ACh) and sodium nitroprusside (SNP) vasodilation and increased nitrite and O(2)(.) Superoxides 108-112 interleukin 1 beta Rattus norvegicus 0-8 16183707-11 2006 The impairment of ACh relaxation induced by IL-1beta was also partially reversed by the xanthine oxidase inhibitor allopurinol (1 mM) but not by either the NADPH oxidase inhibitor apocynin (0.3 mM) or the inducible NOS inhibitor N-3-aminomethylbenzylacetamidine (1 microM). Acetylcholine 18-21 interleukin 1 beta Rattus norvegicus 44-52 16183707-11 2006 The impairment of ACh relaxation induced by IL-1beta was also partially reversed by the xanthine oxidase inhibitor allopurinol (1 mM) but not by either the NADPH oxidase inhibitor apocynin (0.3 mM) or the inducible NOS inhibitor N-3-aminomethylbenzylacetamidine (1 microM). Allopurinol 115-126 interleukin 1 beta Rattus norvegicus 44-52 16183707-11 2006 The impairment of ACh relaxation induced by IL-1beta was also partially reversed by the xanthine oxidase inhibitor allopurinol (1 mM) but not by either the NADPH oxidase inhibitor apocynin (0.3 mM) or the inducible NOS inhibitor N-3-aminomethylbenzylacetamidine (1 microM). N-(3-(aminomethyl)benzyl)acetamidine 229-261 interleukin 1 beta Rattus norvegicus 44-52 16183707-13 2006 The results of the present study demonstrate that long-term incubation with IL-1beta induces an impairment of the nitric oxide-mediated relaxation in mesenteric resistance arteries through the production of O(2)(. Nitric Oxide 114-126 interleukin 1 beta Rattus norvegicus 76-84 16183707-13 2006 The results of the present study demonstrate that long-term incubation with IL-1beta induces an impairment of the nitric oxide-mediated relaxation in mesenteric resistance arteries through the production of O(2)(. Superoxides 207-211 interleukin 1 beta Rattus norvegicus 76-84 16310312-7 2006 Finasteride pretreatment, inhibiting progesterone conversion to allopregnanolone, a positive GABA(A) receptor allosteric modifier, also restores an oxytocin response to interleukin-1beta. Finasteride 0-11 interleukin 1 beta Rattus norvegicus 169-186 17047293-3 2006 STZ-hyperglycemic rats also predisposed the eye to produce high levels of both the cytokines IL-1beta and CXCL8. Streptozocin 0-3 interleukin 1 beta Rattus norvegicus 93-101 16289838-8 2006 The protective effect of minocycline was associated with suppression of hypoxia-ischemia-induced microglial activation as indicated by the decreased number of activated microglia, which were also interleukin-1beta and inducible nitric oxide synthase expressing cells. Minocycline 25-36 interleukin 1 beta Rattus norvegicus 196-213 16785751-11 2006 CONCLUSION: PTX decreased the up-regulated activation of NF-kappaB and the expression of proinflammatory cytokines, TNF-alpha and IL-1beta in rat retinas following ischemia/reperfusion. Pentoxifylline 12-15 interleukin 1 beta Rattus norvegicus 130-138 16054375-6 2006 Poly (ADP-ribose) polymerase fragmentation, caspase-1 activation, and IL-1beta and ICAM-1 mRNA expression were increased by hypoxia-ischemia and significantly reduced in simvastatin-treated animals. Simvastatin 170-181 interleukin 1 beta Rattus norvegicus 70-78 16601920-14 2006 Relative to the control, immunohistochemical staining intensity of the neurotransmitter substance P and of the cytokines TNFalpha and IL-1beta was increased in cells of the bone microenvironment in the Mg depletion group, suggesting that inflammatory cytokines may contribute to bone loss. Magnesium 202-204 interleukin 1 beta Rattus norvegicus 134-142 16238458-13 2006 A transient increase in GGT activity at 24 h, together with a less sharp delineation of GGT-stained vessels, may reflect IL-1beta induced increased turnover of glutathione and/or oxidative stress, that may in turn, be related to altered permeability of the blood-brain barrier in some neurological and mental disorders, including schizophrenia. Glutathione 160-171 interleukin 1 beta Rattus norvegicus 121-129 16369182-11 2006 In contrast, in non-infected animals the combination of O3/O2-PP and TZP enhanced IL-1beta and TNF-alpha mRNA in the spleen and IL-1beta mRNA in liver when compared with TZP- and sham-treated controls. Ozone 56-58 interleukin 1 beta Rattus norvegicus 82-90 16369182-11 2006 In contrast, in non-infected animals the combination of O3/O2-PP and TZP enhanced IL-1beta and TNF-alpha mRNA in the spleen and IL-1beta mRNA in liver when compared with TZP- and sham-treated controls. Ozone 56-58 interleukin 1 beta Rattus norvegicus 128-136 16369182-11 2006 In contrast, in non-infected animals the combination of O3/O2-PP and TZP enhanced IL-1beta and TNF-alpha mRNA in the spleen and IL-1beta mRNA in liver when compared with TZP- and sham-treated controls. o2-pp 59-64 interleukin 1 beta Rattus norvegicus 82-90 16369182-11 2006 In contrast, in non-infected animals the combination of O3/O2-PP and TZP enhanced IL-1beta and TNF-alpha mRNA in the spleen and IL-1beta mRNA in liver when compared with TZP- and sham-treated controls. o2-pp 59-64 interleukin 1 beta Rattus norvegicus 128-136 16369182-11 2006 In contrast, in non-infected animals the combination of O3/O2-PP and TZP enhanced IL-1beta and TNF-alpha mRNA in the spleen and IL-1beta mRNA in liver when compared with TZP- and sham-treated controls. Piperacillin, Tazobactam Drug Combination 69-72 interleukin 1 beta Rattus norvegicus 82-90 16369182-11 2006 In contrast, in non-infected animals the combination of O3/O2-PP and TZP enhanced IL-1beta and TNF-alpha mRNA in the spleen and IL-1beta mRNA in liver when compared with TZP- and sham-treated controls. Piperacillin, Tazobactam Drug Combination 69-72 interleukin 1 beta Rattus norvegicus 128-136 16310312-7 2006 Finasteride pretreatment, inhibiting progesterone conversion to allopregnanolone, a positive GABA(A) receptor allosteric modifier, also restores an oxytocin response to interleukin-1beta. Pregnanolone 64-80 interleukin 1 beta Rattus norvegicus 169-186 16310312-9 2006 In virgin rats allopregnanolone attenuates the oxytocin response to interleukin-1beta, which is exaggerated by naloxone. Pregnanolone 15-31 interleukin 1 beta Rattus norvegicus 68-85 16310312-9 2006 In virgin rats allopregnanolone attenuates the oxytocin response to interleukin-1beta, which is exaggerated by naloxone. Naloxone 111-119 interleukin 1 beta Rattus norvegicus 68-85 16310312-10 2006 The effects of naloxone and finasteride in late pregnant rats in restoring an oxytocin response to interleukin-1beta are not additive. Naloxone 15-23 interleukin 1 beta Rattus norvegicus 99-116 16310312-10 2006 The effects of naloxone and finasteride in late pregnant rats in restoring an oxytocin response to interleukin-1beta are not additive. Finasteride 28-39 interleukin 1 beta Rattus norvegicus 99-116 16310312-11 2006 Accordingly, allopregnanolone may both enhance GABA inhibition of oxytocin neurone responses to interleukin-1beta, and induce opioid suppression of noradrenaline release onto oxytocin neurones. Pregnanolone 13-29 interleukin 1 beta Rattus norvegicus 96-113 16310312-11 2006 Accordingly, allopregnanolone may both enhance GABA inhibition of oxytocin neurone responses to interleukin-1beta, and induce opioid suppression of noradrenaline release onto oxytocin neurones. gamma-Aminobutyric Acid 47-51 interleukin 1 beta Rattus norvegicus 96-113 16219027-4 2005 This neurotoxicity was antagonized by the semisynthetic tetracycline derivative, minocycline, and the observed neuroprotective effects were associated with the ability of minocycline to suppress NADPH oxidase-derived ROS production and pro-inflammatory cytokine expression, including interleukin-1beta and inducible nitric oxide synthase, from activated microglia. Tetracycline 56-68 interleukin 1 beta Rattus norvegicus 284-301 16100244-7 2005 Myocardial interleukin-1beta (IL-1beta)-positive cells and myocardial oxidative stress overload with DNA damage in rats with EAM given MCI-186 treatment were significantly less compared with those of the untreated rats with EAM. molibresib 125-128 interleukin 1 beta Rattus norvegicus 11-28 16100244-7 2005 Myocardial interleukin-1beta (IL-1beta)-positive cells and myocardial oxidative stress overload with DNA damage in rats with EAM given MCI-186 treatment were significantly less compared with those of the untreated rats with EAM. molibresib 125-128 interleukin 1 beta Rattus norvegicus 30-38 16848226-0 2005 Effect of interleukin-1beta on NMDA-induced 45Ca2+ uptake by synaptosomes of rat brain cortex. N-Methylaspartate 31-35 interleukin 1 beta Rattus norvegicus 10-27 16848226-1 2005 The effect of interleukin-1beta on presynaptic NMDA receptors was evaluated by studying NMDA-induced 45Ca2+ uptake by synaptosomes from rat brain cortex. N-Methylaspartate 47-51 interleukin 1 beta Rattus norvegicus 14-31 16219027-4 2005 This neurotoxicity was antagonized by the semisynthetic tetracycline derivative, minocycline, and the observed neuroprotective effects were associated with the ability of minocycline to suppress NADPH oxidase-derived ROS production and pro-inflammatory cytokine expression, including interleukin-1beta and inducible nitric oxide synthase, from activated microglia. Minocycline 81-92 interleukin 1 beta Rattus norvegicus 284-301 16219027-4 2005 This neurotoxicity was antagonized by the semisynthetic tetracycline derivative, minocycline, and the observed neuroprotective effects were associated with the ability of minocycline to suppress NADPH oxidase-derived ROS production and pro-inflammatory cytokine expression, including interleukin-1beta and inducible nitric oxide synthase, from activated microglia. Minocycline 171-182 interleukin 1 beta Rattus norvegicus 284-301 16404139-2 2005 We investigated the effect of a higher dose (60 mg/kg intravenously) of salbutamol, a selective beta(2)-adrenoceptor agonist, on the induction of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha in plasma and the expression of protein and mRNA of metallothioein-1 (MT-1), heme oxygenase-1 (HO-1) and inducible nitric oxide synthase (iNOS) in heart, lung, liver and spleen in rats. Albuterol 72-82 interleukin 1 beta Rattus norvegicus 146-168 16274312-1 2005 BACKGROUND: The aim of the present study was to evaluate the effects of systemic administration of low-dose doxycycline and a bisphosphonate, alendronate, on serum levels of interleukin-1beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis in rats. Doxycycline 108-119 interleukin 1 beta Rattus norvegicus 174-191 16249482-8 2005 ASODN did not significantly affect the expression of VEGF but significantly decreased the expression of IL-1beta at 24 hours (P = 0.04). asodn 0-5 interleukin 1 beta Rattus norvegicus 104-112 16388089-2 2005 In 21-d-old animals local bilateral injection or unilateral administration of 0.1 microg/testis of IL-1beta to hemicastrates resulted in a significant increase in basal testosterone secretion in vitro and serum testosterone concentration one day posttreatment. Testosterone 169-181 interleukin 1 beta Rattus norvegicus 99-107 16388089-2 2005 In 21-d-old animals local bilateral injection or unilateral administration of 0.1 microg/testis of IL-1beta to hemicastrates resulted in a significant increase in basal testosterone secretion in vitro and serum testosterone concentration one day posttreatment. Testosterone 211-223 interleukin 1 beta Rattus norvegicus 99-107 16236122-5 2005 In Cg-treated paws, Gln depletion increased MPO activity by 44% (P < 0.05), interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) concentrations by 47% and 52%, respectively (P < 0.05), and immunostaining for TNF-alpha in paw tissue. Glutamine 20-23 interleukin 1 beta Rattus norvegicus 79-96 16236122-10 2005 Gln depletion potentiates acute inflammation, possibly by increasing neutrophil migration through resident cell activation and production of IL-1beta and TNF-alpha. Glutamine 0-3 interleukin 1 beta Rattus norvegicus 141-149 16274312-1 2005 BACKGROUND: The aim of the present study was to evaluate the effects of systemic administration of low-dose doxycycline and a bisphosphonate, alendronate, on serum levels of interleukin-1beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis in rats. Diphosphonates 126-140 interleukin 1 beta Rattus norvegicus 174-191 16274312-1 2005 BACKGROUND: The aim of the present study was to evaluate the effects of systemic administration of low-dose doxycycline and a bisphosphonate, alendronate, on serum levels of interleukin-1beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis in rats. Diphosphonates 126-140 interleukin 1 beta Rattus norvegicus 193-201 16274312-1 2005 BACKGROUND: The aim of the present study was to evaluate the effects of systemic administration of low-dose doxycycline and a bisphosphonate, alendronate, on serum levels of interleukin-1beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis in rats. Doxycycline 108-119 interleukin 1 beta Rattus norvegicus 193-201 16274312-1 2005 BACKGROUND: The aim of the present study was to evaluate the effects of systemic administration of low-dose doxycycline and a bisphosphonate, alendronate, on serum levels of interleukin-1beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis in rats. Alendronate 142-153 interleukin 1 beta Rattus norvegicus 174-191 16274312-1 2005 BACKGROUND: The aim of the present study was to evaluate the effects of systemic administration of low-dose doxycycline and a bisphosphonate, alendronate, on serum levels of interleukin-1beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis in rats. Alendronate 142-153 interleukin 1 beta Rattus norvegicus 193-201 16154694-6 2005 Subcutaneous administration of CPCCOEt or LY367385, an mGluR1 antagonist, or MPEP or SIB1893, an mGluR5 antagonist, 10 min prior to injection of IL-1beta abolished IL-1beta-induced mechanical allodynia. 7-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester 31-38 interleukin 1 beta Rattus norvegicus 164-172 16274312-10 2005 Significantly higher IL-1beta levels were observed with alendronate either alone or in combination with doxycycline than in the LPS group (P <0.05). Alendronate 56-67 interleukin 1 beta Rattus norvegicus 21-29 16274312-10 2005 Significantly higher IL-1beta levels were observed with alendronate either alone or in combination with doxycycline than in the LPS group (P <0.05). Doxycycline 104-115 interleukin 1 beta Rattus norvegicus 21-29 16221205-8 2005 The 17 kD active IL-1beta remained unchanged, but 35 kD IL-1beta precursor was decreased by rapamycin in comparison with I/R group (P < 0.05). Sirolimus 92-101 interleukin 1 beta Rattus norvegicus 56-64 16059754-2 2005 The rIL-1beta contains a 6-histidine tag at the N-terminus, and protein purification has been achieved through this tag by affinity chromatography. 6-histidine 25-36 interleukin 1 beta Rattus norvegicus 4-13 16154694-7 2005 Pretreatment with APDC or DCG4, a group II mGluR agonist, blocked the IL-1beta-induced mechanical allodynia. Ammonium pyrrolidyldithiocarbamate 18-22 interleukin 1 beta Rattus norvegicus 70-78 16154694-7 2005 Pretreatment with APDC or DCG4, a group II mGluR agonist, blocked the IL-1beta-induced mechanical allodynia. dcg4 26-30 interleukin 1 beta Rattus norvegicus 70-78 16316536-6 2005 RESULTS: The ratio of IL-1beta/IL-1ra at hippocampal CA(1) region in PTZ-IVIG group (0.5 +/- 0.1) was significantly lower than that in PTZ-NS group (1.9 +/- 0.5, t = 12.9, P < 0.05). Pentylenetetrazole 69-72 interleukin 1 beta Rattus norvegicus 22-30 16247326-8 2005 Hypoxia-induced upregulation of TNF-alpha and IL-1beta mRNA in pulmonary artery was decreased by zaprinast, but not milrinone, pretreatment. zaprinast 97-106 interleukin 1 beta Rattus norvegicus 46-54 16247326-9 2005 These results suggest that zaprinast, but not milrinone, preferentially vasodilates pulmonary artery over aorta, attenuates hypoxic pulmonary vasoconstriction, and inhibits hypoxia-induced pulmonary artery TNF-alpha and IL-1beta expression. zaprinast 27-36 interleukin 1 beta Rattus norvegicus 220-228 16419161-8 2005 CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1beta and to the overexpression of HSP70. Pioglitazone 12-24 interleukin 1 beta Rattus norvegicus 177-185 16419161-8 2005 CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1beta and to the overexpression of HSP70. Pioglitazone 74-86 interleukin 1 beta Rattus norvegicus 177-185 15953659-10 2005 The sugar load led to a diabetes-like prolonged elevation of BGL in the IL-1beta treated animals. Sugars 4-9 interleukin 1 beta Rattus norvegicus 72-80 16084017-3 2005 Under pentobarbital sodium anesthesia, a polyethylene tube was implanted in the subcutaneous area of one vibrissa pad, which enabled us to inject IL-1beta. Polyethylene 41-53 interleukin 1 beta Rattus norvegicus 146-154 16084017-10 2005 Intracisternal pretreatment with PD98059, a p44/42 MAPK inhibitor, or SB203580, a p38 MAPK inhibitor, significantly reduced the decrease in the threshold of air puffs ipsilateral to the IL-1beta injection site produced by 10 pg of IL-1beta. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 interleukin 1 beta Rattus norvegicus 186-194 16084017-10 2005 Intracisternal pretreatment with PD98059, a p44/42 MAPK inhibitor, or SB203580, a p38 MAPK inhibitor, significantly reduced the decrease in the threshold of air puffs ipsilateral to the IL-1beta injection site produced by 10 pg of IL-1beta. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 33-40 interleukin 1 beta Rattus norvegicus 231-239 16084017-10 2005 Intracisternal pretreatment with PD98059, a p44/42 MAPK inhibitor, or SB203580, a p38 MAPK inhibitor, significantly reduced the decrease in the threshold of air puffs ipsilateral to the IL-1beta injection site produced by 10 pg of IL-1beta. SB 203580 70-78 interleukin 1 beta Rattus norvegicus 186-194 16084017-10 2005 Intracisternal pretreatment with PD98059, a p44/42 MAPK inhibitor, or SB203580, a p38 MAPK inhibitor, significantly reduced the decrease in the threshold of air puffs ipsilateral to the IL-1beta injection site produced by 10 pg of IL-1beta. SB 203580 70-78 interleukin 1 beta Rattus norvegicus 231-239 16084017-11 2005 IL-1beta-induced mirror-image mechanical allodynia was also reduced significantly by intracisternal pretreatment with both PD98059 and SB203580. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 123-130 interleukin 1 beta Rattus norvegicus 0-8 16084017-11 2005 IL-1beta-induced mirror-image mechanical allodynia was also reduced significantly by intracisternal pretreatment with both PD98059 and SB203580. SB 203580 135-143 interleukin 1 beta Rattus norvegicus 0-8 15888553-7 2005 We also demonstrate that TNF-alpha/IL-1beta stimulation of rat fetal lung (RFL-6) fibroblast cells resulted in sGCalpha1 mRNA inhibition, which was blocked by SP-600125. pyrazolanthrone 159-168 interleukin 1 beta Rattus norvegicus 35-43 16132952-7 2005 RESULTS: Apoptosis in INS-1 cells induced by IL-1beta plus IFNgamma was dependent on NO production as demonstrated by the use of the NOS blocker NG-methyl-L-arginine. ng-methyl-l-arginine 145-165 interleukin 1 beta Rattus norvegicus 45-53 16197515-5 2005 In the present study, cleavage of IL-1beta was chronically inhibited using a specific caspase-1 inhibitor (Ac-YVAD-CMK; 10 pmol) in both aged (22 month) and young (4 month) rats. N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone 107-118 interleukin 1 beta Rattus norvegicus 34-42 16165703-12 2005 Moreover, in TGFbeta-activated cells, nicotinamide reduces expression of pro-inflammatory and pro-fibrotic cytokines TGFbeta2, IL-1beta, TNFalpha and macrophage chemotactic protein-1. Niacinamide 38-50 interleukin 1 beta Rattus norvegicus 127-135 16148608-8 2005 RESULTS: Incubation of cultures with interleukin-1beta for 24 h caused a significant increase in nitrite generation. Nitrites 97-104 interleukin 1 beta Rattus norvegicus 37-54 16148608-9 2005 Interleukin-1beta-induced nitrite production by vascular smooth muscle cells was significantly suppressed by GGA in a dose-dependent manner. Nitrites 26-33 interleukin 1 beta Rattus norvegicus 0-17 16205165-6 2005 The dexamethasone injection reduced the expression of interleukin-1beta and transforming growth factor-beta1 compared with injured vehicle-injected controls and led to a transient improvement of contractile tension 3 days after the injury. Dexamethasone 4-17 interleukin 1 beta Rattus norvegicus 54-108 15965498-4 2005 The increase in plasma concentrations of IL-1beta and IL-6, measured 1 h after LPS treatment, was reduced by PPADS (25 mg kg(-1)) and BBG (100 mg kg(-1)). coomassie Brilliant Blue 134-137 interleukin 1 beta Rattus norvegicus 41-49 16156894-8 2005 Olfactory bulb injections of NMDA+vehicle (preimmune serum) increased IL-1beta and activated the signaling molecule c-jun terminal kinase (JNK)-2 at 6 h. At 24 h, the lesion significantly increased matrix metalloproteinase (MMP)-9 and prostaglandin (PG)E2, a COX-2 mediated metabolite of arachadonic acid. N-Methylaspartate 29-33 interleukin 1 beta Rattus norvegicus 70-78 16115381-9 2005 RESULTS: Expression of iNOS protein and IL-1beta mRNA were increased significantly in the Mec/saline group (both P<0.01) compared with the control group. Sodium Chloride 94-100 interleukin 1 beta Rattus norvegicus 40-48 16023081-8 2005 Ellagic acid inhibited IL-1beta- and TNF-alpha-induced activation of activator protein-1 and mitogen-activated protein kinases (extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38 mitogen-activated protein kinase), but not of nuclear factor-kappaB. Ellagic Acid 0-12 interleukin 1 beta Rattus norvegicus 23-31 15879491-6 2005 Numbers of myocardial interleukin-1beta (IL-1beta)-positive-staining cells (obtained by immunohistochemistry) and quantities of IL-1beta expression (obtained by Western blotting) were significantly lower in rats with EAM given olmesartan treatment compared with rats given vehicle. molibresib 217-220 interleukin 1 beta Rattus norvegicus 22-39 15879491-6 2005 Numbers of myocardial interleukin-1beta (IL-1beta)-positive-staining cells (obtained by immunohistochemistry) and quantities of IL-1beta expression (obtained by Western blotting) were significantly lower in rats with EAM given olmesartan treatment compared with rats given vehicle. molibresib 217-220 interleukin 1 beta Rattus norvegicus 41-49 15879491-6 2005 Numbers of myocardial interleukin-1beta (IL-1beta)-positive-staining cells (obtained by immunohistochemistry) and quantities of IL-1beta expression (obtained by Western blotting) were significantly lower in rats with EAM given olmesartan treatment compared with rats given vehicle. molibresib 217-220 interleukin 1 beta Rattus norvegicus 128-136 15879491-6 2005 Numbers of myocardial interleukin-1beta (IL-1beta)-positive-staining cells (obtained by immunohistochemistry) and quantities of IL-1beta expression (obtained by Western blotting) were significantly lower in rats with EAM given olmesartan treatment compared with rats given vehicle. olmesartan 227-237 interleukin 1 beta Rattus norvegicus 22-39 15965498-1 2005 Adenosine 5"-triphosphate (ATP) has been shown to induce release of cytokines implicated in fever, including interleukin(IL)-1beta, IL-6, and tumour necrosis factor-alpha (TNF-alpha). Adenosine Triphosphate 0-25 interleukin 1 beta Rattus norvegicus 109-130 15965498-1 2005 Adenosine 5"-triphosphate (ATP) has been shown to induce release of cytokines implicated in fever, including interleukin(IL)-1beta, IL-6, and tumour necrosis factor-alpha (TNF-alpha). Adenosine Triphosphate 27-30 interleukin 1 beta Rattus norvegicus 109-130 16077954-9 2005 The potentiating effect of Abeta(25-35) on IL-1beta-induced NF-kappaB binding activity was observed after 30 min, 2 h and 24 h, and did not significantly differ over time. UNII-042A8N37WH 27-32 interleukin 1 beta Rattus norvegicus 43-51 16133968-9 2005 Treatment with TNF-Ab, theophylline, or pentoxifylline significantly reduced serum/tissue TNF-alpha, IL-1beta, nitrate/nitrite, and iNOS expression. Theophylline 23-35 interleukin 1 beta Rattus norvegicus 101-109 16133968-9 2005 Treatment with TNF-Ab, theophylline, or pentoxifylline significantly reduced serum/tissue TNF-alpha, IL-1beta, nitrate/nitrite, and iNOS expression. Pentoxifylline 40-54 interleukin 1 beta Rattus norvegicus 101-109 16023603-5 2005 Isoflurane significantly inhibited plasma levels of TNFalpha and IL-1beta by 69.3% and 61.8%, respectively. Isoflurane 0-10 interleukin 1 beta Rattus norvegicus 65-73 15874975-7 2005 Minocycline reduced accumulation of IL-1beta and CINC-1 in the systemic circulation but failed to affect the increased levels of IL-1beta, IL-18, MCP-1 or CINC-1 in the injured brain tissue. Minocycline 0-11 interleukin 1 beta Rattus norvegicus 36-44 15993952-7 2005 DMF and SP attenuated the LPS-induced production and release of TNFalpha, IL-1beta, IL-6 and NO. Dimethyl Fumarate 0-3 interleukin 1 beta Rattus norvegicus 74-82 16025141-2 2005 Herein, we analyse the role of TNF-alpha and IL-1beta production for PAF-induced B1 receptor upregulation in the rat paw. Platelet Activating Factor 69-72 interleukin 1 beta Rattus norvegicus 45-53 16025141-4 2005 In our experiments, treatment with PAF resulted in a marked increase of B1 receptor-mediated paw oedema and in situ production of TNF-alpha at 1 h and IL-1beta at 3 and 6 h later. Platelet Activating Factor 35-38 interleukin 1 beta Rattus norvegicus 151-159 16025141-6 2005 TNF-alpha was necessary for the local PAF-induced IL-1beta production. Platelet Activating Factor 38-41 interleukin 1 beta Rattus norvegicus 50-58 16025141-9 2005 Although both TNF-alpha and IL-1beta are relevant to functional B1 receptor upregulation, PAF-induced increase in B1 receptor mRNA was markedly suppressed by anti-TNF-alpha and, to a lesser extent, by IRA. Platelet Activating Factor 90-93 interleukin 1 beta Rattus norvegicus 28-36 15993952-7 2005 DMF and SP attenuated the LPS-induced production and release of TNFalpha, IL-1beta, IL-6 and NO. sulforaphane 8-10 interleukin 1 beta Rattus norvegicus 74-82 16141635-1 2005 The effect of docosahexaenoic acid (DHA) on cyclooxygenase expression induced by interleukin (IL)-1beta and phorbol 12-myristate 13-acetate (PMA) in rat vascular smooth muscle cells (VSMCs) was investigated in order to clarify the cellular mechanism of cardiovascular protective effects. Docosahexaenoic Acids 14-34 interleukin 1 beta Rattus norvegicus 81-103 16204770-0 2005 Nitric oxide mediates the interleukin-1beta- and nicotine-induced hypothalamic-pituitary-adrenocortical response during social stress. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 26-43 16204770-1 2005 We investigated the role of nitric oxide (NO) in the interleukin 1beta (IL-1beta) and nicotine induced hypothalamic-pituitary-adrenal axis (HPA) responses, and a possible significance of CRH and vasopressin in these responses under basal and social stress conditions. Nitric Oxide 28-40 interleukin 1 beta Rattus norvegicus 72-80 16141635-1 2005 The effect of docosahexaenoic acid (DHA) on cyclooxygenase expression induced by interleukin (IL)-1beta and phorbol 12-myristate 13-acetate (PMA) in rat vascular smooth muscle cells (VSMCs) was investigated in order to clarify the cellular mechanism of cardiovascular protective effects. Docosahexaenoic Acids 36-39 interleukin 1 beta Rattus norvegicus 81-103 16204770-6 2005 L-NAME (2 mg/kg), a general nitric oxide synthase (NOS) inhibitor, considerably reduced the ACTH and corticosterone response to IL-1beta (0.5 microg/rat) the same extent in control and crowded rats. NG-Nitroarginine Methyl Ester 0-6 interleukin 1 beta Rattus norvegicus 128-136 16141635-2 2005 DHA and eicosapentaenoic acid slightly enhanced IL-1beta-induced cyclooxygenase (COX)-2, but not COX-1, expression, whereas arachidonic acid had no effect. Docosahexaenoic Acids 0-3 interleukin 1 beta Rattus norvegicus 48-56 16204770-6 2005 L-NAME (2 mg/kg), a general nitric oxide synthase (NOS) inhibitor, considerably reduced the ACTH and corticosterone response to IL-1beta (0.5 microg/rat) the same extent in control and crowded rats. Corticosterone 101-115 interleukin 1 beta Rattus norvegicus 128-136 16141635-2 2005 DHA and eicosapentaenoic acid slightly enhanced IL-1beta-induced cyclooxygenase (COX)-2, but not COX-1, expression, whereas arachidonic acid had no effect. Eicosapentaenoic Acid 8-29 interleukin 1 beta Rattus norvegicus 48-56 16141635-4 2005 DHA stimulated both rapid and prolonged activation of p44/42, but not p38, mitogen-activated protein kinase (MAPK) induced by IL-1beta and PMA. Docosahexaenoic Acids 0-3 interleukin 1 beta Rattus norvegicus 126-134 16098663-3 2005 Intra-articular injection of 100 pg or 1 ng of IL-1beta significantly facilitated formalin-induced behavior by 130 or 174% in the number of scratches. Formaldehyde 82-90 interleukin 1 beta Rattus norvegicus 47-55 16098663-4 2005 Intracisternal administration of 100 pg or 1 ng of IL-1beta also significantly increased formalin-induced behavior by 166 or 82% in the number of scratches. Formaldehyde 89-97 interleukin 1 beta Rattus norvegicus 51-59 16098663-6 2005 Intracisternal pretreatment with SC-560, a selective COX-1 inhibitor, or NS-398, a selective COX-2 inhibitor, abolished intra-articular administration of IL-1beta-induced hyperalgesic response. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 73-79 interleukin 1 beta Rattus norvegicus 154-162 16098663-6 2005 Intracisternal pretreatment with SC-560, a selective COX-1 inhibitor, or NS-398, a selective COX-2 inhibitor, abolished intra-articular administration of IL-1beta-induced hyperalgesic response. SC 560 33-39 interleukin 1 beta Rattus norvegicus 154-162 16098663-7 2005 Intracisternal pretreatment with NS-398, a selective COX-2 inhibitor, abolished the intracisternal administration of IL-1beta-induced hyperalgesic response, while pretreatment with SC-560, a selective COX-1 inhibitor, did not change IL-1beta-induced hyperalgesic responses. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 33-39 interleukin 1 beta Rattus norvegicus 117-125 16098663-7 2005 Intracisternal pretreatment with NS-398, a selective COX-2 inhibitor, abolished the intracisternal administration of IL-1beta-induced hyperalgesic response, while pretreatment with SC-560, a selective COX-1 inhibitor, did not change IL-1beta-induced hyperalgesic responses. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 33-39 interleukin 1 beta Rattus norvegicus 233-241 15925388-9 2005 Furthermore, melatonin inhibited the expression of NF-kappaB in liver tissue and decreasing production of proinflammatory cytokines such as TNF-alpha and IL-1beta from KCs in fibrotic rats. Melatonin 13-22 interleukin 1 beta Rattus norvegicus 154-162 16098663-8 2005 On the other hand, pretreatment with acetaminophen, a tentative COX-3 inhibitor, also abolished both intra-articular and intracisternal administration of IL-1beta-induced hyperalgesic responses. Acetaminophen 37-50 interleukin 1 beta Rattus norvegicus 154-162 16079481-5 2005 Additionally, the secretions of IL-1beta, TNF-alpha and IL-6 and the lipase levels were decreased in statin treated group. statin 101-107 interleukin 1 beta Rattus norvegicus 32-40 16094491-1 2005 The purpose of this study is to determine whether aspirin can reduce interleukin-1beta(IL-1beta) concentration and exert protective effects against heatstroke. Aspirin 50-57 interleukin 1 beta Rattus norvegicus 69-86 16094491-1 2005 The purpose of this study is to determine whether aspirin can reduce interleukin-1beta(IL-1beta) concentration and exert protective effects against heatstroke. Aspirin 50-57 interleukin 1 beta Rattus norvegicus 87-95 16038626-1 2005 AIM: To observe whether an amyloid beta (Abeta)-induced increase in interleukin (IL)-1beta was accompanied by an increase in the p38 mitogen-activated protein kinase (MAPK) pathway and a decrease in the cell survival pathway, and whether sodium ferulate (SF) treatment was effective in preventing these Abeta-induced changes. UNII-042A8N37WH 41-46 interleukin 1 beta Rattus norvegicus 68-90 16038626-8 2005 Increased IL-1beta synthesis was accompanied by increased activation of p38 MAPK and downregulation of phospho-ERK and phospho-Akt/PKB in hippocampal CA regions prepared from Abeta-treated rats, leading to cell death as assessed by activation of caspase-3. UNII-042A8N37WH 175-180 interleukin 1 beta Rattus norvegicus 10-18 16038626-9 2005 SF significantly prevented Abeta-induced increases in IL-1beta and p38 MAPK activation and also Abeta-induced changes in phospho-ERK and phospho-Akt/PKB expression levels. UNII-042A8N37WH 27-32 interleukin 1 beta Rattus norvegicus 54-62 15963473-5 2005 We demonstrate that the GR agonist RU 24858, equipotent to dexamethasone (DEX), exhibited strong suppressive effects on the IL-1beta-induced MMP-9 and tPA mRNA levels concomitant with an inhibition of corresponding enzyme activities. Ruthenium 35-37 interleukin 1 beta Rattus norvegicus 124-132 15963473-5 2005 We demonstrate that the GR agonist RU 24858, equipotent to dexamethasone (DEX), exhibited strong suppressive effects on the IL-1beta-induced MMP-9 and tPA mRNA levels concomitant with an inhibition of corresponding enzyme activities. Dexamethasone 74-77 interleukin 1 beta Rattus norvegicus 124-132 15963473-10 2005 Interestingly, the different RUs affected the expression of cAMP-induced tPA and inducible NO synthase with the same potency as the IL-1beta-induced protease expression thus indicating that these compounds equipotently modulate cytokine- and cAMP-driven gene expression. Cyclic AMP 242-246 interleukin 1 beta Rattus norvegicus 132-140 16042547-4 2005 In this paper, we provide evidence to suggest that vitamin D3 acts as an anti-inflammatory agent and reverses the age-related increase in microglial activation and the accompanying increase in IL-1beta (interleukin-1beta) concentration. Cholecalciferol 51-61 interleukin 1 beta Rattus norvegicus 193-201 16042547-4 2005 In this paper, we provide evidence to suggest that vitamin D3 acts as an anti-inflammatory agent and reverses the age-related increase in microglial activation and the accompanying increase in IL-1beta (interleukin-1beta) concentration. Cholecalciferol 51-61 interleukin 1 beta Rattus norvegicus 203-220 15758944-1 2005 Interleukin-1beta (IL-1beta) induces cyclooxygenase-2 (Cox-2) expression in many of its cellular targets resulting in production and release of prostaglandins. Prostaglandins 144-158 interleukin 1 beta Rattus norvegicus 0-17 15828022-10 2005 Individually or together, L-N(G)-monomethylarginine and antibodies to IL-1beta, IL-6, and TNF-alpha only partly reversed qHSC + LPS-conditioned medium-induced inhibition of DNA synthesis in hepatocytes. qhsc 121-125 interleukin 1 beta Rattus norvegicus 70-78 15828022-12 2005 They also indicate that other factors, in addition to NO, TGF-beta, TNF-alpha, IL-1beta, and IL-6 are involved in the mechanisms of the growth inhibitory effects of qHSCs on hepatocytes. qhscs 165-170 interleukin 1 beta Rattus norvegicus 79-87 15758944-1 2005 Interleukin-1beta (IL-1beta) induces cyclooxygenase-2 (Cox-2) expression in many of its cellular targets resulting in production and release of prostaglandins. Prostaglandins 144-158 interleukin 1 beta Rattus norvegicus 19-27 16011486-0 2005 Prostaglandin E2 mediates cellular effects of interleukin-1beta on parvocellular neurones in the paraventricular nucleus of the hypothalamus. Dinoprostone 0-16 interleukin 1 beta Rattus norvegicus 46-63 15972237-2 2005 We studied apoptosis, the levels of TNF-alpha, IL-1beta, and IL-6, and the cell type producing TNF-alpha in rats at 8, 10, and 14 days of age after neonatal exposure to glutamate, which induces neuronal damage. Glutamic Acid 169-178 interleukin 1 beta Rattus norvegicus 47-55 16011486-2 2005 Previously, we have shown that IL-1beta depolarises parvocellular neurones in the paraventricular nucleus (PVN) of the hypothalamus, and these effects are dependent on attenuation of gamma-amino butyric acid (GABA)-ergic input. gamma-Aminobutyric Acid 183-207 interleukin 1 beta Rattus norvegicus 31-39 16011486-3 2005 In the present study, using whole-cell patch clamp recordings of rat neurones in a slice preparation of the PVN, we show that the effects of IL-1beta are abolished in the presence of a cyclooxygenase (COX)-2 inhibitor, NS-398, indicating a dependence on prostaglandin (PG) synthesis and activation. Prostaglandins 269-271 interleukin 1 beta Rattus norvegicus 141-149 16011486-2 2005 Previously, we have shown that IL-1beta depolarises parvocellular neurones in the paraventricular nucleus (PVN) of the hypothalamus, and these effects are dependent on attenuation of gamma-amino butyric acid (GABA)-ergic input. gamma-Aminobutyric Acid 209-213 interleukin 1 beta Rattus norvegicus 31-39 16011486-5 2005 Furthermore, neurones responsive to both IL-1beta and PGE2 exhibited a decrease in the frequency of inhibitory post-synaptic potentials, suggesting that effects of these modulators are mediated via a decrease in GABA-ergic input to these neurones. gamma-Aminobutyric Acid 212-216 interleukin 1 beta Rattus norvegicus 41-49 16011486-6 2005 A proportion (44% and 40%, respectively) of putative GABA-ergic neurones in the halo region surrounding the PVN demonstrated hyperpolarising responses to 1 nM IL-1beta and 1 microM PGE2, and these effects were maintained in TTX. gamma-Aminobutyric Acid 53-57 interleukin 1 beta Rattus norvegicus 159-167 16011486-3 2005 In the present study, using whole-cell patch clamp recordings of rat neurones in a slice preparation of the PVN, we show that the effects of IL-1beta are abolished in the presence of a cyclooxygenase (COX)-2 inhibitor, NS-398, indicating a dependence on prostaglandin (PG) synthesis and activation. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 219-225 interleukin 1 beta Rattus norvegicus 141-149 16011486-6 2005 A proportion (44% and 40%, respectively) of putative GABA-ergic neurones in the halo region surrounding the PVN demonstrated hyperpolarising responses to 1 nM IL-1beta and 1 microM PGE2, and these effects were maintained in TTX. Tetrodotoxin 224-227 interleukin 1 beta Rattus norvegicus 159-167 16033422-2 2005 injection of interleukin-1beta (IL-1beta), at a dose of 100 ng, induces inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production in the spinal cord and results in thermal hyperalgesia in rats. Nitric Oxide 82-94 interleukin 1 beta Rattus norvegicus 13-30 16033422-2 2005 injection of interleukin-1beta (IL-1beta), at a dose of 100 ng, induces inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production in the spinal cord and results in thermal hyperalgesia in rats. Nitric Oxide 82-94 interleukin 1 beta Rattus norvegicus 32-40 16011486-7 2005 Furthermore, direct hyperpolarising effects of IL-1beta were blocked in the presence of NS-398. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 88-94 interleukin 1 beta Rattus norvegicus 47-55 16011486-3 2005 In the present study, using whole-cell patch clamp recordings of rat neurones in a slice preparation of the PVN, we show that the effects of IL-1beta are abolished in the presence of a cyclooxygenase (COX)-2 inhibitor, NS-398, indicating a dependence on prostaglandin (PG) synthesis and activation. Prostaglandins 254-267 interleukin 1 beta Rattus norvegicus 141-149 16011486-8 2005 Together, these data suggest that PGE2, synthesised in response to IL-1beta-activation of COX-2 expressing cells, directly hyperpolarises putative GABA-ergic neurones in the halo zone surrounding and projecting to the PVN, resulting in a decrease in GABA-ergic input to parvocellular neurones and consequent depolarisation. Dinoprostone 34-38 interleukin 1 beta Rattus norvegicus 67-75 16011486-8 2005 Together, these data suggest that PGE2, synthesised in response to IL-1beta-activation of COX-2 expressing cells, directly hyperpolarises putative GABA-ergic neurones in the halo zone surrounding and projecting to the PVN, resulting in a decrease in GABA-ergic input to parvocellular neurones and consequent depolarisation. gamma-Aminobutyric Acid 147-151 interleukin 1 beta Rattus norvegicus 67-75 16011486-8 2005 Together, these data suggest that PGE2, synthesised in response to IL-1beta-activation of COX-2 expressing cells, directly hyperpolarises putative GABA-ergic neurones in the halo zone surrounding and projecting to the PVN, resulting in a decrease in GABA-ergic input to parvocellular neurones and consequent depolarisation. gamma-Aminobutyric Acid 250-254 interleukin 1 beta Rattus norvegicus 67-75 15998432-10 2005 Octreotide suppressed the secretion of IL-1beta and IL-8. Octreotide 0-10 interleukin 1 beta Rattus norvegicus 39-47 15993445-4 2005 Pre-treatment with naloxone methiodide decreased (15%) IL-1beta-induced Fos-immunoreactivity (Fos-IR) in medial parvocellular paraventricular nucleus (mPVN) corticotropin-releasing hormone (CRH) neurons but increased responses in the ventrolateral medulla (VLM) C1 (65%) and nucleus tractus solitarius (NTS) A2 (110%) catecholamine cell groups and area postrema (136%). N-methylnaloxone 19-38 interleukin 1 beta Rattus norvegicus 55-63 15993445-4 2005 Pre-treatment with naloxone methiodide decreased (15%) IL-1beta-induced Fos-immunoreactivity (Fos-IR) in medial parvocellular paraventricular nucleus (mPVN) corticotropin-releasing hormone (CRH) neurons but increased responses in the ventrolateral medulla (VLM) C1 (65%) and nucleus tractus solitarius (NTS) A2 (110%) catecholamine cell groups and area postrema (136%). Catecholamines 318-331 interleukin 1 beta Rattus norvegicus 55-63 15993445-6 2005 We next determined the effect of blocking both central and peripheral opioid receptors with naloxone and, when compared to the naloxone methiodide pre-treated group, a further 60% decrease in Fos-IR mPVN CRH neurons induced by IL-1beta was detected, which was attributed to block of central opioid receptors. N-methylnaloxone 127-146 interleukin 1 beta Rattus norvegicus 227-235 15784009-5 2005 Generation of nitrated guanosine and tyrosine suggested the formation of reactive nitrogen species including ONOO- (peroxynitrite), a reaction product of NO and O2-, in ATDC5 cells and rat primary chondrocytes treated with IL-1beta. Peroxynitrous Acid 116-129 interleukin 1 beta Rattus norvegicus 223-231 16235775-8 2005 Homocysteine, in a dose and time dependent manner, increased expression of matrix metallinoproteinase-9 and interleukin-1beta, which have been implicated in vascular smooth muscle cell migration and/or proliferation. Homocysteine 0-12 interleukin 1 beta Rattus norvegicus 108-125 15967733-5 2005 Pretreatment with NAC partially prevented tumor necrosis factor alpha (TNFalpha) production induced by the low concentration of LPS, while pretreatment with budesonide totally prevented the increased production of TNFalpha, interleukin (IL)-1beta, IL-6, and monocyte chemoattractive protein (MCP)-1 after LPS challenge at both low and high concentrations. Budesonide 157-167 interleukin 1 beta Rattus norvegicus 224-246 16046881-7 2005 Similarly, EtOH blunted the LPS-induced increase in tissue mRNA expression of TNF-alpha and IL-1beta. Ethanol 11-15 interleukin 1 beta Rattus norvegicus 92-100 15784009-5 2005 Generation of nitrated guanosine and tyrosine suggested the formation of reactive nitrogen species including ONOO- (peroxynitrite), a reaction product of NO and O2-, in ATDC5 cells and rat primary chondrocytes treated with IL-1beta. Reactive Nitrogen Species 73-98 interleukin 1 beta Rattus norvegicus 223-231 15784009-5 2005 Generation of nitrated guanosine and tyrosine suggested the formation of reactive nitrogen species including ONOO- (peroxynitrite), a reaction product of NO and O2-, in ATDC5 cells and rat primary chondrocytes treated with IL-1beta. oxido nitrite 109-114 interleukin 1 beta Rattus norvegicus 223-231 15927699-0 2005 Interleukin-1beta depolarizes magnocellular neurons in the paraventricular nucleus of the hypothalamus through prostaglandin-mediated activation of a non selective cationic conductance. Prostaglandins 111-124 interleukin 1 beta Rattus norvegicus 0-17 15927699-4 2005 In response to 1 nM IL-1beta, 62% of MNC neurons tested depolarized (mean depolarization=10.9+/-1.4 mV); effects which were maintained in the presence of a sodium channel blocker, tetrodotoxin (TTX). Tetrodotoxin 180-192 interleukin 1 beta Rattus norvegicus 20-28 15927699-4 2005 In response to 1 nM IL-1beta, 62% of MNC neurons tested depolarized (mean depolarization=10.9+/-1.4 mV); effects which were maintained in the presence of a sodium channel blocker, tetrodotoxin (TTX). Tetrodotoxin 194-197 interleukin 1 beta Rattus norvegicus 20-28 15927699-5 2005 The effects of IL-1beta on MNC neurons were blocked in the presence of a specific cyclooxygenase (COX)-2 inhibitor, NS-398, indicating a dependence on prostaglandins (PG) in mediating these effects. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 116-122 interleukin 1 beta Rattus norvegicus 15-23 15927699-5 2005 The effects of IL-1beta on MNC neurons were blocked in the presence of a specific cyclooxygenase (COX)-2 inhibitor, NS-398, indicating a dependence on prostaglandins (PG) in mediating these effects. Prostaglandins 151-165 interleukin 1 beta Rattus norvegicus 15-23 15927699-5 2005 The effects of IL-1beta on MNC neurons were blocked in the presence of a specific cyclooxygenase (COX)-2 inhibitor, NS-398, indicating a dependence on prostaglandins (PG) in mediating these effects. Prostaglandins 167-169 interleukin 1 beta Rattus norvegicus 15-23 15927699-6 2005 In response to direct application of 1 muM PGE2, 57% of MNC neurons depolarized, exhibiting a membrane potential change similar to that induced by IL-1beta (mean depolarization=7.8+/-1.1 mV). Dinoprostone 43-47 interleukin 1 beta Rattus norvegicus 147-155 15927699-8 2005 These data provide evidence that IL-1beta depolarizes MNC neurons in the PVN as a result of prostaglandin-mediated activation of a NSCC. Prostaglandins 92-105 interleukin 1 beta Rattus norvegicus 33-41 16046881-14 2005 In this regard, EtOH administered within two hr of LPS generally suppressed IL-6, IL-1beta, and TNF-alpha mRNAs in muscle, heart, liver, and spleen. Ethanol 16-20 interleukin 1 beta Rattus norvegicus 82-90 15831571-0 2005 Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells. Calcium 0-7 interleukin 1 beta Rattus norvegicus 33-50 15878884-5 2005 Moreover, a MIP-2-specific antisense oligonucleotide and small interfering RNA attenuated the IL-1beta/TNFalpha-induced expression of sPLA2-IIA, suggesting that MIP-2 is an absolute intermediate requirement for optimal induction of sPLA2-IIA. Oligonucleotides 37-52 interleukin 1 beta Rattus norvegicus 94-102 15831571-4 2005 In insulin-secreting rat INS-1 cells cultured in the presence of 11 mm glucose, combined pharmacological blockade of L- and T-type Ca(2+) channels suppressed IL-1beta-induced in vitro phosphorylation of the JNK substrate c-jun and reduced IL-1beta-stimulated activation of JNK1/2 as assessed by immunoblotting. Glucose 71-78 interleukin 1 beta Rattus norvegicus 158-166 15954894-1 2005 BACKGROUND: Studies have shown that lipoxin A(4) (LXA(4)) and its analogues inhibited proliferation of glomerular mesangial cells induced by leukotriene D(4) (LTD(4)) or platelet-derived growth factor (PDGF), reduced the production of proinflammatory cytokines such as interleukin (IL)-1beta and IL-6 in renal tissue of ischemic injury. lipoxin A4 36-45 interleukin 1 beta Rattus norvegicus 269-291 15729290-5 2005 Candesartan decreased the macrophage infiltration and reversed the enhanced tumor necrosis factor-alpha and interleukin-1beta mRNA and nuclear factor-kappaB in microvessels in hypertensive rats. candesartan 0-11 interleukin 1 beta Rattus norvegicus 108-125 16104441-5 2005 HES significantly reduced the LPS-induced increase in intestinal levels of TNF-alpha, IL-1beta, IL-6, IL-8 and their corresponding mRNAs. Hydroxyethyl Starch Derivatives 0-3 interleukin 1 beta Rattus norvegicus 86-94 15946185-5 2005 The induction of mRNA for these inflammatory proteins by turpentine oil was preceded by a transient increase in the level of mRNAs for IL-1beta, IL-6 and TNF-alpha at 6 h after subcutaneous injection of the oil. Turpentine 57-71 interleukin 1 beta Rattus norvegicus 135-143 15954894-1 2005 BACKGROUND: Studies have shown that lipoxin A(4) (LXA(4)) and its analogues inhibited proliferation of glomerular mesangial cells induced by leukotriene D(4) (LTD(4)) or platelet-derived growth factor (PDGF), reduced the production of proinflammatory cytokines such as interleukin (IL)-1beta and IL-6 in renal tissue of ischemic injury. N-(1H-benzimidazol-2-ylmethyl)-2-methoxyacetamide 50-53 interleukin 1 beta Rattus norvegicus 269-291 15954894-2 2005 In the present studies, we examine whether LXA(4) have inhibitory effects on tumor necrosis factor-alpha (TNF-alpha)-induced productions of IL-1beta and IL-6 and proliferation of glomerular mesangial cells of rat, and explore the molecular mechanisms of signal pathway of LXA(4). N-(1H-benzimidazol-2-ylmethyl)-2-methoxyacetamide 43-46 interleukin 1 beta Rattus norvegicus 140-148 15954894-13 2005 Pretreatment of the cells with NF-kappaB inhibitor pyrrolidine dithio-carbamate (PDTC) blocked the productions of IL-1beta, IL-6, and activation of NF-kappaB induced by TNF-alpha. pyrrolidine dithiocarbamic acid 51-79 interleukin 1 beta Rattus norvegicus 114-122 15954894-13 2005 Pretreatment of the cells with NF-kappaB inhibitor pyrrolidine dithio-carbamate (PDTC) blocked the productions of IL-1beta, IL-6, and activation of NF-kappaB induced by TNF-alpha. pyrrolidine dithiocarbamic acid 81-85 interleukin 1 beta Rattus norvegicus 114-122 15882780-2 2005 The fever induced by IL-1beta was significantly attenuated by pretreatment with intracerebroventricular injection of 5-HT2A receptor antagonists including cyproheptadine, ketanserin, or mianserin. Cyproheptadine 155-169 interleukin 1 beta Rattus norvegicus 21-29 15970284-7 2005 The concentrations of the cytokines interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha and the chemokines CCL5 and CCL2 were significantly decreased in arthritic rats treated with atorvastatin. Atorvastatin 194-206 interleukin 1 beta Rattus norvegicus 36-53 15882780-2 2005 The fever induced by IL-1beta was significantly attenuated by pretreatment with intracerebroventricular injection of 5-HT2A receptor antagonists including cyproheptadine, ketanserin, or mianserin. Ketanserin 171-181 interleukin 1 beta Rattus norvegicus 21-29 15882780-2 2005 The fever induced by IL-1beta was significantly attenuated by pretreatment with intracerebroventricular injection of 5-HT2A receptor antagonists including cyproheptadine, ketanserin, or mianserin. Mianserin 186-195 interleukin 1 beta Rattus norvegicus 21-29 15949713-0 2005 Gut-derived norepinephrine plays an important role in up-regulating IL-1beta and IL-10. Norepinephrine 12-26 interleukin 1 beta Rattus norvegicus 68-76 15882780-3 2005 In addition, the IL-1beta-induced fever was mimicked by intracerebroventricular administration of a 5-HT2A receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-amionpropane (DOI). 1-(2,5-dimethoxy-4-iodophenyl)-2-amionpropane 125-170 interleukin 1 beta Rattus norvegicus 17-25 15949713-9 2005 Co-administration of NE and YHB, however, significantly attenuated IL-1beta and IL-10 production. Yohimbine 28-31 interleukin 1 beta Rattus norvegicus 67-75 15949713-12 2005 Since adenylate cyclase activator forskolin prevents the increase in NE-induced IL-1beta and IL-10, the up-regulatory effect of NE on those cytokines appears to be mediated, at least in part, by inhibition of adenylate cyclase and reduction in intracellular cyclic AMP levels. Colforsin 34-43 interleukin 1 beta Rattus norvegicus 80-88 15882780-4 2005 The DOI-induced (present results) or IL-1beta-induced (previous results) fever was further attenuated by pretreatment with an intracerebroventricular dose of mu-opioid receptor antagonists (e.g., buprenorphine or cyclic d-phe-cys-Try-d-Arg-Thr-pen-Thr-NH2) or 5-HT receptor antagonists (e.g., ketanserin or cyproheptadine). Buprenorphine 196-209 interleukin 1 beta Rattus norvegicus 37-45 15882780-4 2005 The DOI-induced (present results) or IL-1beta-induced (previous results) fever was further attenuated by pretreatment with an intracerebroventricular dose of mu-opioid receptor antagonists (e.g., buprenorphine or cyclic d-phe-cys-Try-d-Arg-Thr-pen-Thr-NH2) or 5-HT receptor antagonists (e.g., ketanserin or cyproheptadine). cyclic d-phe-cys 213-229 interleukin 1 beta Rattus norvegicus 37-45 15882780-4 2005 The DOI-induced (present results) or IL-1beta-induced (previous results) fever was further attenuated by pretreatment with an intracerebroventricular dose of mu-opioid receptor antagonists (e.g., buprenorphine or cyclic d-phe-cys-Try-d-Arg-Thr-pen-Thr-NH2) or 5-HT receptor antagonists (e.g., ketanserin or cyproheptadine). 1,6-Trimethylene-3,5-dichloropyrazine-2(1H)-one 230-233 interleukin 1 beta Rattus norvegicus 37-45 15882780-4 2005 The DOI-induced (present results) or IL-1beta-induced (previous results) fever was further attenuated by pretreatment with an intracerebroventricular dose of mu-opioid receptor antagonists (e.g., buprenorphine or cyclic d-phe-cys-Try-d-Arg-Thr-pen-Thr-NH2) or 5-HT receptor antagonists (e.g., ketanserin or cyproheptadine). -arg-thr-pen-thr-nh2 235-255 interleukin 1 beta Rattus norvegicus 37-45 15882780-4 2005 The DOI-induced (present results) or IL-1beta-induced (previous results) fever was further attenuated by pretreatment with an intracerebroventricular dose of mu-opioid receptor antagonists (e.g., buprenorphine or cyclic d-phe-cys-Try-d-Arg-Thr-pen-Thr-NH2) or 5-HT receptor antagonists (e.g., ketanserin or cyproheptadine). Ketanserin 293-303 interleukin 1 beta Rattus norvegicus 37-45 15882780-4 2005 The DOI-induced (present results) or IL-1beta-induced (previous results) fever was further attenuated by pretreatment with an intracerebroventricular dose of mu-opioid receptor antagonists (e.g., buprenorphine or cyclic d-phe-cys-Try-d-Arg-Thr-pen-Thr-NH2) or 5-HT receptor antagonists (e.g., ketanserin or cyproheptadine). Cyproheptadine 307-321 interleukin 1 beta Rattus norvegicus 37-45 15885234-2 2005 Fructose leads to experimental steatosis in the liver by exerting its effect on some components of the oxidant/antioxidant system, and on several cytokines (interleukin-1beta, -2, and -6) in blood. Fructose 0-8 interleukin 1 beta Rattus norvegicus 157-186 15885234-7 2005 In addition, increased IL-1beta and IL-6 levels were kept at near to normal levels with treatment of Talpha(1), but not IL-2 levels. talpha 101-107 interleukin 1 beta Rattus norvegicus 23-31 15930438-0 2005 Quercetin attenuates nuclear factor-kappaB activation and nitric oxide production in interleukin-1beta-activated rat hepatocytes. Quercetin 0-9 interleukin 1 beta Rattus norvegicus 85-102 15958288-6 2005 RESULTS: CTOL evidently reduced the severity of postoperative adhesions and decreased the serum levels of the proinflammatory cytokines such as TNF-alpha, IL-1beta, TGF-beta(1) and IL-6. ctol 9-13 interleukin 1 beta Rattus norvegicus 155-163 15986861-13 2005 Increases in the gastric content of TNF-alpha and IL-1beta after aspirin administration were inhibited by pretreatment with rolipram. Aspirin 65-72 interleukin 1 beta Rattus norvegicus 50-58 15986861-13 2005 Increases in the gastric content of TNF-alpha and IL-1beta after aspirin administration were inhibited by pretreatment with rolipram. Rolipram 124-132 interleukin 1 beta Rattus norvegicus 50-58 23674954-1 2005 OBJECTIVE: To investigate the influence of bizhongxiao decoction (BZXD) which is a Traditional Chinese medicine for RA including, on the plasma TNF-alpha and IL-1beta in rats with CII-induced arthritis (CIA) and explore the protective mechanism of BZXD in the treatment of rheumatoid arthritis. bzxd 66-70 interleukin 1 beta Rattus norvegicus 158-166 23674954-11 2005 The plasma TNF-alpha and IL-1beta levels of CIA group, BZXD group and MTX group were notably higher than those of normal control group (p<0.05), moreover, the CIA group was higher than those of the MTX group and BZXD group at various interval (p<0.01). Methotrexate 70-73 interleukin 1 beta Rattus norvegicus 25-33 23674954-12 2005 TNF-alpha and IL-1beta rose step by step in CIA group but decreased in BZXD group and MTX group gradually. bzxd 71-75 interleukin 1 beta Rattus norvegicus 14-22 23674954-12 2005 TNF-alpha and IL-1beta rose step by step in CIA group but decreased in BZXD group and MTX group gradually. Methotrexate 86-89 interleukin 1 beta Rattus norvegicus 14-22 23674954-15 2005 BZXD can notably decrease the plasma TNF-alpha and IL-1beta levels, which was better than MTX. bzxd 0-4 interleukin 1 beta Rattus norvegicus 51-59 15930438-1 2005 We investigated whether different concentrations of the flavonoid quercetin ameliorate nitric oxide production and nuclear factor (NF)-kappaB activation in interleukin (IL)-1beta-activated rat hepatocytes. Quercetin 66-75 interleukin 1 beta Rattus norvegicus 156-178 15930438-4 2005 Quercetin at 100 micromol/L significantly prevented the IL-1beta-induced release of nitrite into the culture medium. Quercetin 0-9 interleukin 1 beta Rattus norvegicus 56-64 15930438-4 2005 Quercetin at 100 micromol/L significantly prevented the IL-1beta-induced release of nitrite into the culture medium. Nitrites 84-91 interleukin 1 beta Rattus norvegicus 56-64 15930438-5 2005 Western blot and reverse transcription-PCR analyses demonstrated that increased levels of inducible nitric oxide synthase (iNOS) protein and mRNA in hepatocytes stimulated by IL-1beta were prevented by 50 micromol/L and 100 micromol/L of quercetin. Quercetin 238-247 interleukin 1 beta Rattus norvegicus 175-183 15930438-6 2005 Electrophoretic mobility shift assay experiments and Western blots indicated that quercetin blocked the activation of NF-kappaB and decreased the inhibitor kappaB protein levels induced by IL-1beta. Quercetin 82-91 interleukin 1 beta Rattus norvegicus 189-197 15930438-0 2005 Quercetin attenuates nuclear factor-kappaB activation and nitric oxide production in interleukin-1beta-activated rat hepatocytes. Nitric Oxide 58-70 interleukin 1 beta Rattus norvegicus 85-102 15930438-1 2005 We investigated whether different concentrations of the flavonoid quercetin ameliorate nitric oxide production and nuclear factor (NF)-kappaB activation in interleukin (IL)-1beta-activated rat hepatocytes. Flavonoids 56-65 interleukin 1 beta Rattus norvegicus 156-178 15888326-0 2005 Ageing alters the production of nitric oxide and prostanoids after IL-1beta exposure in mesenteric resistance arteries. Nitric Oxide 32-44 interleukin 1 beta Rattus norvegicus 67-75 15888326-0 2005 Ageing alters the production of nitric oxide and prostanoids after IL-1beta exposure in mesenteric resistance arteries. Prostaglandins 49-60 interleukin 1 beta Rattus norvegicus 67-75 15833600-0 2005 Systemic Interleukin-1beta stimulates the simultaneous release of norepinephrine in the paraventricular nucleus and the median eminence. Norepinephrine 66-80 interleukin 1 beta Rattus norvegicus 9-26 15045524-11 2005 CONCLUSION: Treatment with a somostatin analogue attenuated early inflammatory changes in AIA joints and increased mRNA expression of IL-1beta in the articular tissues of rats with ongoing arthritis. somostatin 29-39 interleukin 1 beta Rattus norvegicus 134-142 15927991-11 2005 MCT-induced PH was also associated with increased expression of various cytokines, but only interleukin-1beta and monocyte chemotactic protein-1 increased at the early phase and stimulated 5-HTT expression by cultured PA-SMCs. pa-smcs 218-225 interleukin 1 beta Rattus norvegicus 92-109 15917452-12 2005 IL-1beta increased noradrenaline release in the PVN of virgin, but not pregnant, rats. Norepinephrine 19-32 interleukin 1 beta Rattus norvegicus 0-8 15917452-13 2005 However, naloxone infused directly into the PVN increased noradrenaline release after IL-1beta in pregnant rats. Naloxone 9-17 interleukin 1 beta Rattus norvegicus 86-94 15917452-13 2005 However, naloxone infused directly into the PVN increased noradrenaline release after IL-1beta in pregnant rats. Norepinephrine 58-71 interleukin 1 beta Rattus norvegicus 86-94 15964419-0 2005 Peritransplant and long-term secretion of interleukin-1beta in cyclosporine treated syngeneic rats allografted with islets of langerhans. Cyclosporine 63-75 interleukin 1 beta Rattus norvegicus 42-59 15964419-14 2005 Our results suggest that IL-1beta secretion, which is detrimental for islet engraftment, decreases at peritransplant day +2, but is upregulated during long-term graft survival both in controls and in CyA-treated recipients. Cyclosporine 200-203 interleukin 1 beta Rattus norvegicus 25-33 15755725-6 2005 IL-1beta significantly reduced the amiloride-sensitive fraction of the transepithelial current and sodium transport across rat ATII cell monolayers. Amiloride 35-44 interleukin 1 beta Rattus norvegicus 0-8 15836676-7 2005 HES significantly reduced the increased hepatic levels of TNF-alpha, IL-1beta, IL-6, IL-8 and the mRNAs in the endotoxemic rats. Hydroxyethyl Starch Derivatives 0-3 interleukin 1 beta Rattus norvegicus 69-77 15869713-1 2005 We report that N-acetyl-L-cysteine (NAC) treatment blocked induction of TNF-alpha, IL-1beta, IFN-gamma and iNOS in the CNS and attenuated clinical disease in the myelin basic protein induced model of experimental allergic encephalomyelitis (EAE) in Lewis rats. Acetylcysteine 15-34 interleukin 1 beta Rattus norvegicus 83-91 15774288-8 2005 SB203580 inhibited the activation of p38 MAP kinase, reduced the levels of TNF-alpha and IL-1beta, and prevented burn-mediated liver injury. SB 203580 0-8 interleukin 1 beta Rattus norvegicus 89-97 15869713-1 2005 We report that N-acetyl-L-cysteine (NAC) treatment blocked induction of TNF-alpha, IL-1beta, IFN-gamma and iNOS in the CNS and attenuated clinical disease in the myelin basic protein induced model of experimental allergic encephalomyelitis (EAE) in Lewis rats. Acetylcysteine 36-39 interleukin 1 beta Rattus norvegicus 83-91 15932594-7 2005 Treatment of NMDA-lesioned OHSCs with IL-1beta exacerbated neuronal cell death and further enhanced microglial cell numbers. N-Methylaspartate 13-17 interleukin 1 beta Rattus norvegicus 38-46 15909595-6 2005 RESULTS: Increased concentration of glucose had a weak, but significant stimulatory effect on sPLA2-IIA expression, which was markedly up-regulated (2-3-fold) in IL-1beta treated mesangial cells compared to the levels obtained in low glucose medium. Glucose 36-43 interleukin 1 beta Rattus norvegicus 162-170 15909595-6 2005 RESULTS: Increased concentration of glucose had a weak, but significant stimulatory effect on sPLA2-IIA expression, which was markedly up-regulated (2-3-fold) in IL-1beta treated mesangial cells compared to the levels obtained in low glucose medium. Glucose 234-241 interleukin 1 beta Rattus norvegicus 162-170 15855300-6 2005 Consistent with these results, the rate of hypothalamic HA turnover, assessed by the accumulation of tele-methylhistamine (t-MH), was elevated with ip injections of LPS and IL-1beta, but unaffected by TNF-alpha at equivalent doses. tele-methylhistamine 101-121 interleukin 1 beta Rattus norvegicus 173-181 15855300-6 2005 Consistent with these results, the rate of hypothalamic HA turnover, assessed by the accumulation of tele-methylhistamine (t-MH), was elevated with ip injections of LPS and IL-1beta, but unaffected by TNF-alpha at equivalent doses. tele-methylhistamine 123-127 interleukin 1 beta Rattus norvegicus 173-181 15583962-0 2005 Intra-parenchymal injection of tumor necrosis factor-alpha and interleukin 1-beta produces dopamine neuron loss in the rat. Dopamine 91-99 interleukin 1 beta Rattus norvegicus 63-81 15877292-8 2005 Immunohistochemistry revealed marked suppression of expressions of tumor necrosis factor alpha , interleukin 1 beta , interleukin 6, and alpha-smooth muscle actin in the islets of camostat-treated rats, compared with control rats. camostat 180-188 interleukin 1 beta Rattus norvegicus 97-115 15971681-0 2005 Production of ex vivo lipopolysaccharide-induced tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 is suppressed by trans-resveratrol in a concentration-dependent manner. Resveratrol 132-149 interleukin 1 beta Rattus norvegicus 78-95 15932707-6 2005 After 4 weeks therapy, metoprolol reduced the production of TNF-alpha and IL-1beta and increased IL-10 levels (P < 0.05) in cardiac myocytes, but had no effect on the number of lymphocytes infiltrated in myocardium. Metoprolol 23-33 interleukin 1 beta Rattus norvegicus 74-82 15763362-6 2005 In a definite concentration ranging from 30 to 120 microg/ml, SN showed inhibiting effect on the NF-kappaB activity and the expression of the mRNAs of TNF-alpha and IL-1beta in AA rats in a concentration-dependent manner (P<0.05). sinomenine 62-64 interleukin 1 beta Rattus norvegicus 165-173 16075741-0 2005 [Effect of geniposide on serum IL-1beta and TNF-alpha of rheumatoid arthritis rats]. geniposide 11-21 interleukin 1 beta Rattus norvegicus 31-39 16075741-1 2005 OBJECTIVE: To study the effect of geniposide on serum IL-1beta and TNF-alpha levels of rheumatoid arthritis rats, as well as the mechanism of this drug. geniposide 34-44 interleukin 1 beta Rattus norvegicus 54-62 16075741-4 2005 RESULT: Compared with the model, geniposide delayed the starting time of right paw edema significantly, and the levels of serum IL-1beta and TNF-alpha were significantly decreased by geniposide at high dose or medium dose (P < 0.01). geniposide 183-193 interleukin 1 beta Rattus norvegicus 128-136 16075741-5 2005 CONCLUSION: Geniposide can lower serum IL-1beta and TNF-alpha levels in rheumatoid arthritis rats. geniposide 12-22 interleukin 1 beta Rattus norvegicus 39-47 15769453-5 2005 RESULTS: (1) IL-1beta time-dependently increased the levels of two molecular forms of adrenomedullin, adrenomedullin-mature and adrenomedullin-glycine (P<0.01). Glycine 142-150 interleukin 1 beta Rattus norvegicus 13-21 15769453-8 2005 (3) Preincubated IL-1beta elevated the intracellular cAMP response to exogenous adrenomedullin administered at a concentration of 10(-7) M (+26%, P<0.05). Cyclic AMP 53-57 interleukin 1 beta Rattus norvegicus 17-25 15971681-7 2005 The production of inflammatory (TNF-alpha and IL-1beta) and anti-inflammatory (IL-6) cytokines was suppressed by trans-resveratrol in a concentration-dependent manner. Resveratrol 113-130 interleukin 1 beta Rattus norvegicus 46-54 15707879-9 2005 IL-1beta, IL-6, TNFalpha and NO levels increased after ethanol administration in SHAM and OVX rats. Ethanol 55-62 interleukin 1 beta Rattus norvegicus 0-8 15792947-5 2005 Treatment with CS plus GS, but not CS alone, significantly reduced clinical scores, incidences of disease, joint temperatures, and joint and serum IL-1beta levels. Chondroitin Sulfates 15-17 interleukin 1 beta Rattus norvegicus 147-155 15389634-0 2005 Interleukin (IL)-1beta toxicity to islet beta cells: Efaroxan exerts a complete protection. efaroxan 53-61 interleukin 1 beta Rattus norvegicus 0-22 15389634-1 2005 Interleukin (IL)-1beta-treated rat islets of Langerhans were exposed in vitro either to the imidazoline compound, Efaroxan, or to the selective inducible nitric oxide synthase (iNOS) inhibitor, 1400W, in a medium containing a high concentration of glucose (16.7 mmol/L). Imidazolines 92-103 interleukin 1 beta Rattus norvegicus 0-22 15389634-1 2005 Interleukin (IL)-1beta-treated rat islets of Langerhans were exposed in vitro either to the imidazoline compound, Efaroxan, or to the selective inducible nitric oxide synthase (iNOS) inhibitor, 1400W, in a medium containing a high concentration of glucose (16.7 mmol/L). efaroxan 114-122 interleukin 1 beta Rattus norvegicus 0-22 15389634-1 2005 Interleukin (IL)-1beta-treated rat islets of Langerhans were exposed in vitro either to the imidazoline compound, Efaroxan, or to the selective inducible nitric oxide synthase (iNOS) inhibitor, 1400W, in a medium containing a high concentration of glucose (16.7 mmol/L). N-((3-(aminomethyl)phenyl)methyl)ethanimidamide 194-199 interleukin 1 beta Rattus norvegicus 0-22 15389634-1 2005 Interleukin (IL)-1beta-treated rat islets of Langerhans were exposed in vitro either to the imidazoline compound, Efaroxan, or to the selective inducible nitric oxide synthase (iNOS) inhibitor, 1400W, in a medium containing a high concentration of glucose (16.7 mmol/L). Glucose 248-255 interleukin 1 beta Rattus norvegicus 0-22 15389634-3 2005 Thus, Efaroxan completely protected islet beta cells from damage caused by IL-1beta-induced toxicity, while compound 1400W only inhibited NO radical production without altering the cytokine"s cytotoxicity. efaroxan 6-14 interleukin 1 beta Rattus norvegicus 75-83 15840993-0 2005 Methylprednisolone inhibits production of interleukin-1beta and interleukin-6 in the spinal cord following compression injury in rats. Methylprednisolone 0-18 interleukin 1 beta Rattus norvegicus 42-59 15840993-2 2005 This study sought to evaluate the effects of methylprednisolone (MP) on IL-1beta and IL-6 protein in spinal cord tissue following SCI. Methylprednisolone 45-63 interleukin 1 beta Rattus norvegicus 72-80 15840993-2 2005 This study sought to evaluate the effects of methylprednisolone (MP) on IL-1beta and IL-6 protein in spinal cord tissue following SCI. Methylprednisolone 65-67 interleukin 1 beta Rattus norvegicus 72-80 15808840-6 2005 Use of specific pharmacologic inhibitors indicated that the tyrosine kinase inhibitors, herbimycin A and geldanamycin, completely reversed IL-1beta-induced downregulation of the VLDL receptor expression. herbimycin 88-100 interleukin 1 beta Rattus norvegicus 139-147 15808840-6 2005 Use of specific pharmacologic inhibitors indicated that the tyrosine kinase inhibitors, herbimycin A and geldanamycin, completely reversed IL-1beta-induced downregulation of the VLDL receptor expression. geldanamycin 105-117 interleukin 1 beta Rattus norvegicus 139-147 15737438-15 2005 The DHA-induced post-transcriptional normalization of MnSOD, CuZnSOD, COX-2 and IL-1beta levels and the decreased edema formation suggest that hyperglycemia accelerates superoxide formation and the inflammatory response, thus contributing to early damage in hyperglycemic stroke and strategies to scavenge superoxide should be an important therapeutic avenue. Dehydroascorbic Acid 4-7 interleukin 1 beta Rattus norvegicus 80-88 15707879-12 2005 In ovariectomized and SHAM rats, administration of L-NAME together with ethanol, produced a significant increase in IL-1beta, IL-6 and TNFalpha levels. NG-Nitroarginine Methyl Ester 51-57 interleukin 1 beta Rattus norvegicus 116-124 15707879-12 2005 In ovariectomized and SHAM rats, administration of L-NAME together with ethanol, produced a significant increase in IL-1beta, IL-6 and TNFalpha levels. Ethanol 72-79 interleukin 1 beta Rattus norvegicus 116-124 15832818-0 2005 Agastache rugosa leaf extract inhibits the iNOS expression in ROS 17/2.8 cells activated with TNF-alpha and IL-1beta. ros 62-65 interleukin 1 beta Rattus norvegicus 108-116 15516486-7 2005 Cytokine-induced neutrophil chemoattractants (CINCs) 1-3, the rat growth-related oncogene-alpha family homologs, and IL-1beta demonstrated time-dependent increases in lung tissue or lavage fluid over the 24-h period following CS exposure. Cesium 226-228 interleukin 1 beta Rattus norvegicus 117-125 15681303-6 2005 In comparison with vehicle-treated SHRSP, rosuvastatin treatment attenuated the transcription of monocyte chemoattractant protein-1, transforming growth factor-beta1, IL-1beta, and tumor necrosis factor-alpha in the kidney, and of P-selectin in brain vessels and increased the transcription of endothelial nitric oxide synthase mRNA in the aorta. Rosuvastatin Calcium 42-54 interleukin 1 beta Rattus norvegicus 167-175 15868110-5 2005 Nitrite, IL-1beta and TNF-alpha were significantly higher in macrophage supernatants and sera of the acutely affected STZ-LETO rats either with or without LPS stimulation compared to corresponding controls. Streptozocin 118-121 interleukin 1 beta Rattus norvegicus 9-17 15683716-3 2005 We found that interleukin-1beta (IL-1beta) stimulated the production of hydrogen peroxide (H2O2) which could be inhibited by loading the cells with the H2O2-scavenging enzyme catalase. Hydrogen Peroxide 72-89 interleukin 1 beta Rattus norvegicus 14-31 15751073-0 2005 Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism. Rosiglitazone 0-13 interleukin 1 beta Rattus norvegicus 59-76 15751073-7 2005 RESULTS: IL-1beta-induced IL-1Ra production was increased by 10 microM rosiglitazone but was reduced dose-dependently by 15-deoxy-PGJ(2). Rosiglitazone 71-84 interleukin 1 beta Rattus norvegicus 9-17 15751073-7 2005 RESULTS: IL-1beta-induced IL-1Ra production was increased by 10 microM rosiglitazone but was reduced dose-dependently by 15-deoxy-PGJ(2). 15-deoxy-pgj 121-133 interleukin 1 beta Rattus norvegicus 9-17 15751073-8 2005 Both agonists lowered IL-1beta secretion, but rosiglitazone alone reduced the imbalance of IL-1beta/IL-1Ra toward basal levels. Rosiglitazone 46-59 interleukin 1 beta Rattus norvegicus 91-99 15751073-9 2005 Enhancement of IL-1beta-induced IL-1Ra production by rosiglitazone was not affected by PPARgamma overexpression or by its inhibition with dominant-negative PPARgamma or GW-9662. Rosiglitazone 53-66 interleukin 1 beta Rattus norvegicus 15-23 15734859-6 2005 STZ hyperglycemic rats also predisposed the heart to produce high levels of the cytokines interleukin (IL)-1beta and CXCL8. Streptozocin 0-3 interleukin 1 beta Rattus norvegicus 90-112 15813930-8 2005 In contrast, although IL-1beta and IL-1RI were elevated to similar levels in response to NMDA challenge, the response was delayed and IL-1RII mRNA expression was unchanged. N-Methylaspartate 89-93 interleukin 1 beta Rattus norvegicus 22-30 15683716-3 2005 We found that interleukin-1beta (IL-1beta) stimulated the production of hydrogen peroxide (H2O2) which could be inhibited by loading the cells with the H2O2-scavenging enzyme catalase. Hydrogen Peroxide 72-89 interleukin 1 beta Rattus norvegicus 33-41 15683716-3 2005 We found that interleukin-1beta (IL-1beta) stimulated the production of hydrogen peroxide (H2O2) which could be inhibited by loading the cells with the H2O2-scavenging enzyme catalase. Hydrogen Peroxide 91-95 interleukin 1 beta Rattus norvegicus 14-31 15683716-3 2005 We found that interleukin-1beta (IL-1beta) stimulated the production of hydrogen peroxide (H2O2) which could be inhibited by loading the cells with the H2O2-scavenging enzyme catalase. Hydrogen Peroxide 91-95 interleukin 1 beta Rattus norvegicus 33-41 15683716-3 2005 We found that interleukin-1beta (IL-1beta) stimulated the production of hydrogen peroxide (H2O2) which could be inhibited by loading the cells with the H2O2-scavenging enzyme catalase. Hydrogen Peroxide 152-156 interleukin 1 beta Rattus norvegicus 14-31 15683716-3 2005 We found that interleukin-1beta (IL-1beta) stimulated the production of hydrogen peroxide (H2O2) which could be inhibited by loading the cells with the H2O2-scavenging enzyme catalase. Hydrogen Peroxide 152-156 interleukin 1 beta Rattus norvegicus 33-41 15683716-4 2005 Inhibition of the upstream ERK1,2 activator MEK1,2 with U0126 prevented IL-1beta-stimulated iNOS expression, while the p38MAPK inhibitor SB03580 potentiated iNOS expression. U 0126 56-61 interleukin 1 beta Rattus norvegicus 72-80 15854535-0 2005 [Effects of carvedilol on the expression of IL-1beta and collagen precipitation in myocardium in post-myocardial infarction rats ]. Carvedilol 12-22 interleukin 1 beta Rattus norvegicus 44-52 15883745-1 2005 OBJECTIVE AND DESIGN: P2X(7) receptor activation by ATP results in the release of IL-1beta and IL-18. Adenosine Triphosphate 52-55 interleukin 1 beta Rattus norvegicus 82-90 15713338-0 2005 Effects of HI 6, diazepam and atropine on soman-induced IL-1 beta protein in rat brain. Soman 42-47 interleukin 1 beta Rattus norvegicus 56-65 15713338-4 2005 In this paper we focus on the cytokine IL-1beta induction in the rat brain after soman-intoxication (1.0 x LD50 and 1.1 x LD50) and during antidote treatment. Soman 81-86 interleukin 1 beta Rattus norvegicus 39-47 15713338-7 2005 The study also demonstrated that atropine alone was more effective against IL-1beta up-regulation after soman-intoxication within the 2-h time frame, than the combination of the HI 6 and atropine, the therapy of choice in many countries. Atropine 33-41 interleukin 1 beta Rattus norvegicus 75-83 15713338-8 2005 Furthermore, treatment with a combination of diazepam and atropine maintained IL-1beta levels at normal when administered at the onset of the seizures following soman exposure. Diazepam 45-53 interleukin 1 beta Rattus norvegicus 78-86 15713338-8 2005 Furthermore, treatment with a combination of diazepam and atropine maintained IL-1beta levels at normal when administered at the onset of the seizures following soman exposure. Atropine 58-66 interleukin 1 beta Rattus norvegicus 78-86 15830285-6 2005 Plasma tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) decreased significantly in the gabexate mesilate-treated rats compared with saline-treated rats. Gabexate 111-128 interleukin 1 beta Rattus norvegicus 51-68 15830285-6 2005 Plasma tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) decreased significantly in the gabexate mesilate-treated rats compared with saline-treated rats. Gabexate 111-128 interleukin 1 beta Rattus norvegicus 70-78 15683463-6 2005 Treatment with melatonin significantly increased the levels of IL-1beta, IL-6, nitrite/nitrate and LPO in joints. Melatonin 15-24 interleukin 1 beta Rattus norvegicus 63-71 15773051-1 2005 We investigated the role of IL-1alpha and IL-1beta expressed in the reactive gliosis following hippocampal damage induced by trimethyltin (TMT). trimethyltin 125-137 interleukin 1 beta Rattus norvegicus 42-50 15773051-1 2005 We investigated the role of IL-1alpha and IL-1beta expressed in the reactive gliosis following hippocampal damage induced by trimethyltin (TMT). trimethyltin 139-142 interleukin 1 beta Rattus norvegicus 42-50 15713265-5 2005 In contrast, in the brain, ciglitazone administration increased IL-1beta synthesis at the protein and mRNA level, while TNF-alpha protein expression was also increased. ciglitazone 27-38 interleukin 1 beta Rattus norvegicus 64-72 15713265-6 2005 To ensure that the latter findings were not an indirect effect originating from the periphery, we delivered ciglitazone intracerebrally for a 7-day period using an osmotic pump, which confirmed the increase in IL-1beta and TNF-alpha expression. ciglitazone 108-119 interleukin 1 beta Rattus norvegicus 210-218 15454397-5 2005 When rat beta-cells were cultured for 24 h with nontoxic interleukin (IL)-1beta concentrations that suppressed glucose-induced insulin release, cellular GABA content was not decreased and GABA release increased by 90% in the period 8-24 h. These data indicate that a reduction in cellular and medium GABA levels is more sensitive than insulin as a marker for the presence of dead beta-cells in isolated preparations. Glucose 111-118 interleukin 1 beta Rattus norvegicus 57-79 15880951-5 2005 MATERIAL AND METHODS: The expression of c-fos and IL-1beta was identified after injecting saline solution, 10 microg of lipopolysaccharide or 100 microg of lipopolysaccharide into the larynx of 12 rats. Sodium Chloride 90-96 interleukin 1 beta Rattus norvegicus 50-58 15663898-1 2005 AIM: To investigate the effects of complete Freund adjuvant (CFA) on inflammatory hyperalgesia and morphological change of the coexistence of interleukin-1 beta (IL-1beta) and type I IL-1 receptor (IL-1RI) in neurons and glia cells of rat dorsal root ganglion (DRG). 3-chloro-4-fluoroaniline 61-64 interleukin 1 beta Rattus norvegicus 142-160 15454397-5 2005 When rat beta-cells were cultured for 24 h with nontoxic interleukin (IL)-1beta concentrations that suppressed glucose-induced insulin release, cellular GABA content was not decreased and GABA release increased by 90% in the period 8-24 h. These data indicate that a reduction in cellular and medium GABA levels is more sensitive than insulin as a marker for the presence of dead beta-cells in isolated preparations. gamma-Aminobutyric Acid 153-157 interleukin 1 beta Rattus norvegicus 57-79 15454397-5 2005 When rat beta-cells were cultured for 24 h with nontoxic interleukin (IL)-1beta concentrations that suppressed glucose-induced insulin release, cellular GABA content was not decreased and GABA release increased by 90% in the period 8-24 h. These data indicate that a reduction in cellular and medium GABA levels is more sensitive than insulin as a marker for the presence of dead beta-cells in isolated preparations. gamma-Aminobutyric Acid 188-192 interleukin 1 beta Rattus norvegicus 57-79 15454397-5 2005 When rat beta-cells were cultured for 24 h with nontoxic interleukin (IL)-1beta concentrations that suppressed glucose-induced insulin release, cellular GABA content was not decreased and GABA release increased by 90% in the period 8-24 h. These data indicate that a reduction in cellular and medium GABA levels is more sensitive than insulin as a marker for the presence of dead beta-cells in isolated preparations. gamma-Aminobutyric Acid 188-192 interleukin 1 beta Rattus norvegicus 57-79 15685554-7 2005 At the long-term level, vitamin D(3) , lipopolysaccharide, thyroid hormone T(3), dexamethasone, platelet-derived growth factor, endothelin 1, and interleukin 1beta up-regulate connexin 43 protein and messenger RNA expression and enhance intercellular communication. Vitamin D 24-33 interleukin 1 beta Rattus norvegicus 146-163 15685554-7 2005 At the long-term level, vitamin D(3) , lipopolysaccharide, thyroid hormone T(3), dexamethasone, platelet-derived growth factor, endothelin 1, and interleukin 1beta up-regulate connexin 43 protein and messenger RNA expression and enhance intercellular communication. thyroid hormone t 59-76 interleukin 1 beta Rattus norvegicus 146-163 15683432-9 2005 The gastric content of MPO, TNF-alpha and IL-1beta were all increased after water-immersion stress and reduced to near normal levels by ATL-146e. Water 76-81 interleukin 1 beta Rattus norvegicus 42-50 15647746-5 2005 Treatment with GSNO reduced the expression of tumor necrosis factor-alpha, interleukin-1beta, and iNOS; inhibited the activation of microglia/macrophage (ED1, CD11-b); and downregulated the expression of leukocyte function-associated antigen-1 and intercellular adhesion molecule-1 in the ischemic brain. S-Nitrosoglutathione 15-19 interleukin 1 beta Rattus norvegicus 75-92 15647747-9 2005 Occasional IL-1beta+/ED-1+ macrophages/microglia were observed in the PVN and SCN exclusively in brain-injured animals developing PTH. pth 130-133 interleukin 1 beta Rattus norvegicus 11-19 15665080-11 2005 As in rats, the final mediators of this cascade were prostaglandins released by IL-1beta and sympathetic amines released by KC. Prostaglandins 53-67 interleukin 1 beta Rattus norvegicus 80-88 21166160-8 2005 Furthermore, pioglitazone reduced the mRNA expression of proinflammatory cytokines, including interleukin-1 beta and cardiotrophin-1, and inhibited the pressure overload-induced increase in the ratio of heart weight to body weight, left ventricular wall thickness and myocyte diameter of rats in vivo. Pioglitazone 13-25 interleukin 1 beta Rattus norvegicus 94-112 15842901-9 2005 In vivo administration of SB203580 markedly suppressed both the release of TNF-alpha and IL-1beta and the mRNA expressions of TNF-alpha and IL-1beta in KCs from both sham and burn rats. SB 203580 26-34 interleukin 1 beta Rattus norvegicus 89-97 15842901-9 2005 In vivo administration of SB203580 markedly suppressed both the release of TNF-alpha and IL-1beta and the mRNA expressions of TNF-alpha and IL-1beta in KCs from both sham and burn rats. SB 203580 26-34 interleukin 1 beta Rattus norvegicus 140-148 15680274-8 2005 RESULTS: Histamine alone reduced ulcer area evoked by stress and this effect was accompanied by an increase in gastric mucosal blood flow and mucosal DNA synthesis, as well as a decrease in serum pro-inflammatory interleukin-1beta concentration. Histamine 9-18 interleukin 1 beta Rattus norvegicus 213-230 15680274-9 2005 Treatment with combination of pyrilamine plus histamine caused an increase in gastric ulcer area and serum interleukin-1beta above the value observed in animals treated with saline, and this effect was accompanied by a decrease in gastric mucosal DNA synthesis. Pyrilamine 30-40 interleukin 1 beta Rattus norvegicus 107-124 15680274-9 2005 Treatment with combination of pyrilamine plus histamine caused an increase in gastric ulcer area and serum interleukin-1beta above the value observed in animals treated with saline, and this effect was accompanied by a decrease in gastric mucosal DNA synthesis. Histamine 46-55 interleukin 1 beta Rattus norvegicus 107-124 15680274-10 2005 Ranitidine, in combination with histamine, reduced the ulcer area and serum interleukin-1beta to a minimal value, whereas gastric mucosal blood flow and DNA synthesis reached a maximal value. Ranitidine 0-10 interleukin 1 beta Rattus norvegicus 76-93 15680274-10 2005 Ranitidine, in combination with histamine, reduced the ulcer area and serum interleukin-1beta to a minimal value, whereas gastric mucosal blood flow and DNA synthesis reached a maximal value. Histamine 32-41 interleukin 1 beta Rattus norvegicus 76-93 15544852-0 2005 Central administration of a nitric oxide precursor abolishes both the hypothalamic serotonin release and the hypophagia induced by interleukin-1beta in obese Zucker rats. Nitric Oxide 28-40 interleukin 1 beta Rattus norvegicus 131-148 15670336-9 2005 RESULTS: Rat microglial cells express alpha7 nicotinic receptor, and its activation by nicotine dose-dependently reduces the LPS-induced release of TNF-alpha, but has little or no effect on nitric oxide, interleukin-10 and interleukin-1beta. Nicotine 87-95 interleukin 1 beta Rattus norvegicus 223-240 15544852-2 2005 More recently, interleukin-1beta and nitric oxide have been suggested to influence this control, possibly through modulation of hypothalamic serotonin. Serotonin 141-150 interleukin 1 beta Rattus norvegicus 15-32 15544852-10 2005 Since L-arginine, probably through NO stimulation, abolished both the anorexia and the serotonergic activation, it can be proposed that the NO system, either directly or indirectly, counteracts IL-1beta anorexia. Arginine 6-16 interleukin 1 beta Rattus norvegicus 194-202 15589968-7 2005 In addition, rat islets pretreated with CR extract retained the insulin-secretion capacity even after the treatment with IL-1beta. Chromium 40-42 interleukin 1 beta Rattus norvegicus 121-129 15730430-2 2005 In the present study, we used a low dose of propofol (5 mg/kg per h) to investigate its effects on the pro-inflammatory cytokines (tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-10) and changes in nitric oxide (NO) following lipopolysaccharide (LPS) for a period of 12 h in conscious rats. Propofol 44-52 interleukin 1 beta Rattus norvegicus 167-189 15308481-9 2005 Candesartan decreased (P < 0.05) blood pressure levels, aortic mRNA expression of IL-1beta, IL-6, and TNF-alpha, and (P < 0.05) IL-1beta and IL-6 plasma concentration. candesartan 0-11 interleukin 1 beta Rattus norvegicus 85-93 15308481-9 2005 Candesartan decreased (P < 0.05) blood pressure levels, aortic mRNA expression of IL-1beta, IL-6, and TNF-alpha, and (P < 0.05) IL-1beta and IL-6 plasma concentration. candesartan 0-11 interleukin 1 beta Rattus norvegicus 134-142 16277686-4 2005 Levels of 6-keto-PGF1alpha and PGE2 peaked 24 hours after stimulation with IL-1beta; the induction of PGE2 was greater (11-fold versus 70-fold, respectively). 6-Ketoprostaglandin F1 alpha 10-26 interleukin 1 beta Rattus norvegicus 75-83 16277686-4 2005 Levels of 6-keto-PGF1alpha and PGE2 peaked 24 hours after stimulation with IL-1beta; the induction of PGE2 was greater (11-fold versus 70-fold, respectively). Dinoprostone 31-35 interleukin 1 beta Rattus norvegicus 75-83 16277686-9 2005 EMSA and TransAM analyses demonstrated that mutated IkappaBalpha almost completely suppressed the stimulating effect of IL-1beta on mPGES-1 expression and PGE2 production, whereas 15d-PGJ2 inhibited NF-kappaB transactivation. Dinoprostone 155-159 interleukin 1 beta Rattus norvegicus 120-128 15883752-8 2005 Simvastatin markedly attenuated the production of TNF-alpha, IL-1beta, IL-6 and increased IL-10 levels in the noninfarcted and infarcted regions, reduced collagen deposition in the noninfarcted myocardium and improved left ventricular function. Simvastatin 0-11 interleukin 1 beta Rattus norvegicus 61-69 15730430-10 2005 Post-treatment with propofol suppressed the release of TNF-alpha, IL-1beta, IL-10 and NO production after endotoxin shock. Propofol 20-28 interleukin 1 beta Rattus norvegicus 66-74 15572270-0 2005 Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Loxapine 19-27 interleukin 1 beta Rattus norvegicus 35-52 15459112-3 2005 In this study, the effect of silymarin on IL-1beta and/or interferon (IFN)-gamma-induced beta-cell damage was investigated using RINm5F cells and human islets. Silymarin 29-38 interleukin 1 beta Rattus norvegicus 42-50 15572270-4 2005 The aim of this study was to evaluate the effect of chlorpromazine and loxapine on release of IL-1beta and IL-2 by mixed glial and microglial cell cultures. Chlorpromazine 52-66 interleukin 1 beta Rattus norvegicus 94-102 15572270-0 2005 Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Chlorpromazine 0-14 interleukin 1 beta Rattus norvegicus 35-52 15572270-4 2005 The aim of this study was to evaluate the effect of chlorpromazine and loxapine on release of IL-1beta and IL-2 by mixed glial and microglial cell cultures. Loxapine 71-79 interleukin 1 beta Rattus norvegicus 94-102 15572270-5 2005 Chlorpromazine in concentrations 2 and 20 muM, and loxapine 0.2, 2 and 20 microM reduced IL-1beta secretion by LPS-activated mixed glia cultures after 1 and 3 days of exposure. Loxapine 51-59 interleukin 1 beta Rattus norvegicus 89-97 15589521-6 2005 This effect began 0.5 h after administration and was continued up to 72 h. Pretreatment of the kindled animals with nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester, or cyclooxygenase inhibitor, piroxicam, reversed the anticonvulsant effect of IL-1beta at early time points. NG-Nitroarginine Methyl Ester 149-183 interleukin 1 beta Rattus norvegicus 263-271 15390105-8 2005 In FK506-treated rats, a significant reduction of IL-1beta, IL-6, and TNF-alpha expression was observed 12 h after reperfusion. Tacrolimus 3-8 interleukin 1 beta Rattus norvegicus 50-58 15390105-9 2005 FK506 neuroprotection was associated with a significant downregulation of IL-1beta expression in astrocytes and microglia in the injured side. Tacrolimus 0-5 interleukin 1 beta Rattus norvegicus 74-82 15578044-3 2005 IL-1beta reduced dramatically beta-cell replication in adult rat islets both at 5.5 mM (control: 0.29+/-0.04%; IL-1beta: 0.02+/-0.02%, P<0.05) and 22.2 mM glucose (control: 0.84+/-0.2%; IL-1beta: 0.05+/-0.05%, P<0.05). Glucose 158-165 interleukin 1 beta Rattus norvegicus 0-8 15390105-10 2005 FK506 selectively decreased the levels of TNF-alpha, and IL-1beta mRNAs in astrocytes in vitro, with no effect on transforming growth factor-beta 1 (TGF-beta1) and IL-6 expression. Tacrolimus 0-5 interleukin 1 beta Rattus norvegicus 57-65 16259750-8 2005 The protective effect of pioglitazone was accompanied by the significant rise in the GBF, an increase in PGE2 generation and the significant fall in the plasma TNF-alpha and IL-1beta levels. Pioglitazone 25-37 interleukin 1 beta Rattus norvegicus 174-182 16259750-9 2005 Strong signals for IL-1beta- and TNF-alpha mRNA were recorded in gastric mucosa exposed to ethanol or WRS, and these effects were significantly decreased by pioglitazone. Ethanol 91-98 interleukin 1 beta Rattus norvegicus 19-27 16259750-9 2005 Strong signals for IL-1beta- and TNF-alpha mRNA were recorded in gastric mucosa exposed to ethanol or WRS, and these effects were significantly decreased by pioglitazone. Pioglitazone 157-169 interleukin 1 beta Rattus norvegicus 19-27 16259750-13 2005 We conclude that (1) pioglitazone exerts a potent gastroprotective and hyperaemic actions on the stomach involving endogenous PG and NO and attenuation of the expression and release of proinflammatory cytokines TNF-alpha and IL-1beta, and (2) PPAR-gamma ligand accelerates ulcer healing, possibly due to the enhancement in angiogenesis at ulcer margin. Pioglitazone 21-33 interleukin 1 beta Rattus norvegicus 225-233 16201258-1 2005 To explore the mechanism of epilepsy induced by IL-1beta and IL-6, the changes of glutamic acid (Glu) and GABA immunoreaction in the cerebral cortex and hippocampus of rats with seizure induced by IL-1beta or IL-6 were studied. Glutamic Acid 82-95 interleukin 1 beta Rattus norvegicus 197-205 15643139-1 2005 OBJECTIVE: Nicotinamide adenine dinucleotide phosphate (NAD(P)H) oxidase is regulated by angiotensin II, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha via p38 mitogen-activated protein kinase (MAPK). NADP 11-54 interleukin 1 beta Rattus norvegicus 105-127 16201258-5 2005 Compared with the controls, the immunoreaction of Glu was significantly increased, while GABA was obviously decreased in IL-1beta group and IL-6 group after 120 min. gamma-Aminobutyric Acid 89-93 interleukin 1 beta Rattus norvegicus 121-129 16201258-6 2005 Our study suggested that the IL-1beta and II-6 might promote and induce epilepsy by increasing Glu and decreasing GABA in the cerebral cortex and hippocampus. Glutamic Acid 95-98 interleukin 1 beta Rattus norvegicus 29-37 16201258-6 2005 Our study suggested that the IL-1beta and II-6 might promote and induce epilepsy by increasing Glu and decreasing GABA in the cerebral cortex and hippocampus. gamma-Aminobutyric Acid 114-118 interleukin 1 beta Rattus norvegicus 29-37 16043966-5 2005 Among inhibitors of intracellular signaling transduction pathways, mitogen-activated protein kinase kinase (MAPKK/MEK) inhibitor PD98059 (40 microM) and p38 MAPK inhibitor SB203580 (5 microM)blocked completely the stimulatory effect of IL-1beta, and the phosphoinositide 3-kinase inhibitor LY294002 (10 microM) blocked partially the induction of IL-1beta. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 129-136 interleukin 1 beta Rattus norvegicus 236-244 15639000-7 2005 Aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, and ascorbic acid, an antioxidant, decreased IL-1beta, TNF-alpha contents and hyperglycaemia. Ascorbic Acid 73-86 interleukin 1 beta Rattus norvegicus 114-122 15639000-5 2005 LPS-induced increases in plasma interleukin-1beta (IL-beta), IL-6, interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and blood glucose levels were significantly inhibited by eugenosedin-A (1 mg kg(-1), i. v.). eugenosedin-A 195-208 interleukin 1 beta Rattus norvegicus 32-49 15639000-6 2005 The same dose of trazodone, a chloropiperazinylbenzene-type antidepressant, and yohimbine, an alpha(2)-adrenoceptor antagonist, reduced IL-1beta and TNF-alpha, but it could not inhibit hyperglycaemia. Trazodone 17-26 interleukin 1 beta Rattus norvegicus 136-144 15639000-6 2005 The same dose of trazodone, a chloropiperazinylbenzene-type antidepressant, and yohimbine, an alpha(2)-adrenoceptor antagonist, reduced IL-1beta and TNF-alpha, but it could not inhibit hyperglycaemia. Yohimbine 80-89 interleukin 1 beta Rattus norvegicus 136-144 15639000-7 2005 Aminoguanidine, an inducible nitric oxide synthase (iNOS) inhibitor, and ascorbic acid, an antioxidant, decreased IL-1beta, TNF-alpha contents and hyperglycaemia. pimagedine 0-14 interleukin 1 beta Rattus norvegicus 114-122 16043966-5 2005 Among inhibitors of intracellular signaling transduction pathways, mitogen-activated protein kinase kinase (MAPKK/MEK) inhibitor PD98059 (40 microM) and p38 MAPK inhibitor SB203580 (5 microM)blocked completely the stimulatory effect of IL-1beta, and the phosphoinositide 3-kinase inhibitor LY294002 (10 microM) blocked partially the induction of IL-1beta. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 129-136 interleukin 1 beta Rattus norvegicus 346-354 16043966-5 2005 Among inhibitors of intracellular signaling transduction pathways, mitogen-activated protein kinase kinase (MAPKK/MEK) inhibitor PD98059 (40 microM) and p38 MAPK inhibitor SB203580 (5 microM)blocked completely the stimulatory effect of IL-1beta, and the phosphoinositide 3-kinase inhibitor LY294002 (10 microM) blocked partially the induction of IL-1beta. SB 203580 172-180 interleukin 1 beta Rattus norvegicus 236-244 16043966-5 2005 Among inhibitors of intracellular signaling transduction pathways, mitogen-activated protein kinase kinase (MAPKK/MEK) inhibitor PD98059 (40 microM) and p38 MAPK inhibitor SB203580 (5 microM)blocked completely the stimulatory effect of IL-1beta, and the phosphoinositide 3-kinase inhibitor LY294002 (10 microM) blocked partially the induction of IL-1beta. SB 203580 172-180 interleukin 1 beta Rattus norvegicus 346-354 15632700-6 2005 Immunohistochemical studies of the pancreas showed that expressions of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, and alpha-smooth muscle actin in camostat-treated rats were greatly suppressed compared with those in the untreated control rats. camostat 167-175 interleukin 1 beta Rattus norvegicus 71-88 15893639-8 2005 The protective effect of minocycline was associated with suppressed microglial activation as indicated by the decreased number of activated microglial cells following LPS stimulation and with consequently decreased elevation of interleukin 1beta and tumor necrosis factor-alpha concentrations induced by LPS and a reduced number of inducible nitric oxide synthase expressing cells. Minocycline 25-36 interleukin 1 beta Rattus norvegicus 228-277 16165281-0 2005 3,4-Methylenedioxymethamphetamine increases pro-interleukin-1beta production and caspase-1 protease activity in frontal cortex, but not in hypothalamus, of Dark Agouti rats: role of interleukin-1beta in neurotoxicity. N-Methyl-3,4-methylenedioxyamphetamine 0-33 interleukin 1 beta Rattus norvegicus 48-65 16165281-0 2005 3,4-Methylenedioxymethamphetamine increases pro-interleukin-1beta production and caspase-1 protease activity in frontal cortex, but not in hypothalamus, of Dark Agouti rats: role of interleukin-1beta in neurotoxicity. N-Methyl-3,4-methylenedioxyamphetamine 0-33 interleukin 1 beta Rattus norvegicus 182-199 16165281-1 2005 3,4-Methylenedioxymethamphetamine (ecstasy) increases mature interleukin-1beta production in rat brain shortly after injection. N-Methyl-3,4-methylenedioxyamphetamine 0-33 interleukin 1 beta Rattus norvegicus 61-78 16165281-1 2005 3,4-Methylenedioxymethamphetamine (ecstasy) increases mature interleukin-1beta production in rat brain shortly after injection. N-Methyl-3,4-methylenedioxyamphetamine 35-42 interleukin 1 beta Rattus norvegicus 61-78 16165281-4 2005 3,4-Methylenedioxymethamphetamine increased the immunoreactivity of pro-interleukin-1beta in frontal cortex, not in hypothalamus, 3 h and 6 h after administration. N-Methyl-3,4-methylenedioxyamphetamine 0-33 interleukin 1 beta Rattus norvegicus 72-89 16165281-9 2005 These data indicate that 3,4-methylenedioxymethamphetamine alters, in a region-specific manner, the mechanisms which regulate interleukin-1beta production in the brain of Dark Agouti rats and suggest that the release of interleukin-1beta in hypothalamus may be regulated independently of caspase-1 activation. N-Methyl-3,4-methylenedioxyamphetamine 25-58 interleukin 1 beta Rattus norvegicus 126-143 16165281-9 2005 These data indicate that 3,4-methylenedioxymethamphetamine alters, in a region-specific manner, the mechanisms which regulate interleukin-1beta production in the brain of Dark Agouti rats and suggest that the release of interleukin-1beta in hypothalamus may be regulated independently of caspase-1 activation. N-Methyl-3,4-methylenedioxyamphetamine 25-58 interleukin 1 beta Rattus norvegicus 220-237 16165281-11 2005 of interleukin-1beta enhanced the 3,4-methylenedioxymethamphetamine-induced long-term loss of brain 5-HT parameters and immediate hyperthermia. N-Methyl-3,4-methylenedioxyamphetamine 34-67 interleukin 1 beta Rattus norvegicus 3-20 16165281-13 2005 These results indicate that exogenous interleukin-1beta potentiates 3,4-methylenedioxymethamphetamine neurotoxicity as a consequence of its effect on body temperature and suggest that the 3,4-methylenedioxymethamphetamine-induced rise in interleukin-1beta levels could in turn contribute to the maintenance of 3,4-methylenedioxymethamphetamine-induced hyperthermia and subsequent neurotoxicity. N-Methyl-3,4-methylenedioxyamphetamine 68-101 interleukin 1 beta Rattus norvegicus 38-55 16165281-13 2005 These results indicate that exogenous interleukin-1beta potentiates 3,4-methylenedioxymethamphetamine neurotoxicity as a consequence of its effect on body temperature and suggest that the 3,4-methylenedioxymethamphetamine-induced rise in interleukin-1beta levels could in turn contribute to the maintenance of 3,4-methylenedioxymethamphetamine-induced hyperthermia and subsequent neurotoxicity. N-Methyl-3,4-methylenedioxyamphetamine 188-221 interleukin 1 beta Rattus norvegicus 38-55 16165281-13 2005 These results indicate that exogenous interleukin-1beta potentiates 3,4-methylenedioxymethamphetamine neurotoxicity as a consequence of its effect on body temperature and suggest that the 3,4-methylenedioxymethamphetamine-induced rise in interleukin-1beta levels could in turn contribute to the maintenance of 3,4-methylenedioxymethamphetamine-induced hyperthermia and subsequent neurotoxicity. N-Methyl-3,4-methylenedioxyamphetamine 188-221 interleukin 1 beta Rattus norvegicus 238-255 16165281-13 2005 These results indicate that exogenous interleukin-1beta potentiates 3,4-methylenedioxymethamphetamine neurotoxicity as a consequence of its effect on body temperature and suggest that the 3,4-methylenedioxymethamphetamine-induced rise in interleukin-1beta levels could in turn contribute to the maintenance of 3,4-methylenedioxymethamphetamine-induced hyperthermia and subsequent neurotoxicity. N-Methyl-3,4-methylenedioxyamphetamine 188-221 interleukin 1 beta Rattus norvegicus 38-55 16165281-13 2005 These results indicate that exogenous interleukin-1beta potentiates 3,4-methylenedioxymethamphetamine neurotoxicity as a consequence of its effect on body temperature and suggest that the 3,4-methylenedioxymethamphetamine-induced rise in interleukin-1beta levels could in turn contribute to the maintenance of 3,4-methylenedioxymethamphetamine-induced hyperthermia and subsequent neurotoxicity. N-Methyl-3,4-methylenedioxyamphetamine 188-221 interleukin 1 beta Rattus norvegicus 238-255 16165282-6 2005 Prazosin attenuated stress-induced plasma IL-1beta and IL-6, but had no effect on tissue IL-1beta levels, while propranolol attenuated plasma IL-6 and blocked tissue IL-1beta elevation, and labetalol, which cannot cross the blood-brain barrier, attenuated plasma IL-1beta and IL-6, blocked pituitary IL-1beta, but had no effect on central tissue IL-1beta levels. Prazosin 0-8 interleukin 1 beta Rattus norvegicus 42-50 16165282-7 2005 Furthermore, administration of 50.0 mg/kg N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride, a neurotoxin that lesions neural projections from the locus coeruleus, prevented stress-induced elevation in hippocampal IL-1beta, a region highly innervated by the locus coeruleus, but had no effect on hypothalamic IL-1beta, a region that receives few locus coeruleus projections. DSP-4 hydrochloride 42-100 interleukin 1 beta Rattus norvegicus 223-231 16165282-7 2005 Furthermore, administration of 50.0 mg/kg N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride, a neurotoxin that lesions neural projections from the locus coeruleus, prevented stress-induced elevation in hippocampal IL-1beta, a region highly innervated by the locus coeruleus, but had no effect on hypothalamic IL-1beta, a region that receives few locus coeruleus projections. DSP-4 hydrochloride 42-100 interleukin 1 beta Rattus norvegicus 318-326 16165282-9 2005 injection of 5.0 mg/kg isoproterenol (beta-adrenoceptor agonist) was sufficient to induce circulating IL-1 and IL-6, and tissue IL-1beta. Isoproterenol 23-36 interleukin 1 beta Rattus norvegicus 128-136 15304373-3 2004 Adrenalectomy (ADX) increased hypothalamic IL-1beta mRNA levels twofold, measured by real-time PCR (P < 0.05 vs. sham-operated controls), and this effect was blocked by subcutaneous infusion of a physiological dose of corticosterone. Corticosterone 221-235 interleukin 1 beta Rattus norvegicus 43-51 15471850-4 2004 In this study, we have shown that treatment of rat islets with IL-1beta or human islets with a cytokine mixture containing IL-1beta + IFN-gamma +/- TNF-alpha stimulates COX-2 expression and PGE(2) formation in a time-dependent manner. Prostaglandins E 190-193 interleukin 1 beta Rattus norvegicus 63-71 15271652-0 2004 Epidermal growth factor and interleukin-1beta synergistically stimulate the production of nitric oxide in rat intestinal epithelial cells. Nitric Oxide 90-102 interleukin 1 beta Rattus norvegicus 28-45 15304373-5 2004 Moreover, fasting for 48 h (which lowers leptin and raises corticosterone levels) reduced hypothalamic IL-1beta mRNA levels by 30% (P = 0.02), and this decrease was fully reversed by refeeding for 12 h. Thus leptin and GCs exert opposing effects on hypothalamic IL-1beta gene expression, and corticosterone plays a physiological role to limit expression of this cytokine in both the presence and absence of intact leptin signaling. Corticosterone 59-73 interleukin 1 beta Rattus norvegicus 103-111 15304373-5 2004 Moreover, fasting for 48 h (which lowers leptin and raises corticosterone levels) reduced hypothalamic IL-1beta mRNA levels by 30% (P = 0.02), and this decrease was fully reversed by refeeding for 12 h. Thus leptin and GCs exert opposing effects on hypothalamic IL-1beta gene expression, and corticosterone plays a physiological role to limit expression of this cytokine in both the presence and absence of intact leptin signaling. Corticosterone 292-306 interleukin 1 beta Rattus norvegicus 103-111 15304373-7 2004 These data support a model in which expression of hypothalamic IL-1beta is subject to opposing physiological regulation by corticosterone and leptin. Corticosterone 123-137 interleukin 1 beta Rattus norvegicus 63-71 15477222-9 2004 SB239063, U0126 and SP600125 dose-dependently inhibited IL-1beta-dependent proliferation at doses that inhibit the activities of p38, ERK and JNK MAPKs, respectively. SB 239063 0-8 interleukin 1 beta Rattus norvegicus 56-64 15605101-0 2004 [Genistein inhibits the promotive effect of IL-1beta on osteoclastic bone resorption]. Genistein 1-10 interleukin 1 beta Rattus norvegicus 44-52 15605101-1 2004 OBJECTIVE: To investigate the effect of genistein, a soybean-derived isoflavone, on the stimulating effect on bone resorption of IL-1beta. Genistein 40-49 interleukin 1 beta Rattus norvegicus 129-137 15605101-1 2004 OBJECTIVE: To investigate the effect of genistein, a soybean-derived isoflavone, on the stimulating effect on bone resorption of IL-1beta. Isoflavones 69-79 interleukin 1 beta Rattus norvegicus 129-137 15605101-9 2004 The index of bone resorption of 10(-6) mol/L genisteine + 10 microg//L IL-1beta lied between 10(-6) mol/L genistein and 10 mug/L IL-1beta. Sparteine 45-55 interleukin 1 beta Rattus norvegicus 129-137 15605101-13 2004 CONCLUSION: Genistein can suppress obviously the bone resorption simulated by single IL-1beta. Genistein 12-21 interleukin 1 beta Rattus norvegicus 85-93 15520047-4 2004 Pentoxifylline also inhibited the mechanical hypernociception in rats induced by the intraplantar injection of either carrageenin (-81%), bradykinin (-56%) or tumor necrosis factor alpha (TNF-alpha; -46%), but not that induced by interleukin-1beta (IL-1beta) or prostaglandin E(2) (PGE(2)). Pentoxifylline 0-14 interleukin 1 beta Rattus norvegicus 230-247 15520047-4 2004 Pentoxifylline also inhibited the mechanical hypernociception in rats induced by the intraplantar injection of either carrageenin (-81%), bradykinin (-56%) or tumor necrosis factor alpha (TNF-alpha; -46%), but not that induced by interleukin-1beta (IL-1beta) or prostaglandin E(2) (PGE(2)). Pentoxifylline 0-14 interleukin 1 beta Rattus norvegicus 249-257 15520047-8 2004 Pentoxifylline significantly reduced TNF-alpha (-43%) and IL-1beta (-42%) concentrations in the joint exudates of rats stimulated by intra-articular injection of zymosan and the production of both cytokines (-66 and -86%, respectively) by mouse peritoneal macrophages stimulated in vivo with zymosan as well as the expression of TNF-alpha at the tissue level in carrageenin-injected rat paws. Pentoxifylline 0-14 interleukin 1 beta Rattus norvegicus 58-66 15520047-8 2004 Pentoxifylline significantly reduced TNF-alpha (-43%) and IL-1beta (-42%) concentrations in the joint exudates of rats stimulated by intra-articular injection of zymosan and the production of both cytokines (-66 and -86%, respectively) by mouse peritoneal macrophages stimulated in vivo with zymosan as well as the expression of TNF-alpha at the tissue level in carrageenin-injected rat paws. Zymosan 162-169 interleukin 1 beta Rattus norvegicus 58-66 15520047-9 2004 In conclusion, the antinociceptive activity of pentoxifylline is associated with the inhibition of the release of both TNF-alpha and IL-1beta. Pentoxifylline 47-61 interleukin 1 beta Rattus norvegicus 133-141 15477222-9 2004 SB239063, U0126 and SP600125 dose-dependently inhibited IL-1beta-dependent proliferation at doses that inhibit the activities of p38, ERK and JNK MAPKs, respectively. U 0126 10-15 interleukin 1 beta Rattus norvegicus 56-64 15477222-9 2004 SB239063, U0126 and SP600125 dose-dependently inhibited IL-1beta-dependent proliferation at doses that inhibit the activities of p38, ERK and JNK MAPKs, respectively. pyrazolanthrone 20-28 interleukin 1 beta Rattus norvegicus 56-64 15604057-5 2004 Curcumin and sulfasalazine obviously suppressed the high expression of proinflammatory cytokine interleukin (IL)-1beta mRNA and increased the low expression of IL-10 mRNA in the colonic mucosa. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 96-118 15561930-4 2004 We show that IL-1beta decreases insulin-induced tyrosine phosphorylation of the insulin receptor (IR) and insulin receptor substrate (IRS) proteins as well as phosphatidylinositol 3-kinase (PI3K) activation, and that this action is not due to the IL-1beta-dependent nitric oxide (NO) production in RINm5F cells. Tyrosine 48-56 interleukin 1 beta Rattus norvegicus 13-21 15561930-4 2004 We show that IL-1beta decreases insulin-induced tyrosine phosphorylation of the insulin receptor (IR) and insulin receptor substrate (IRS) proteins as well as phosphatidylinositol 3-kinase (PI3K) activation, and that this action is not due to the IL-1beta-dependent nitric oxide (NO) production in RINm5F cells. Tyrosine 48-56 interleukin 1 beta Rattus norvegicus 247-255 15561930-4 2004 We show that IL-1beta decreases insulin-induced tyrosine phosphorylation of the insulin receptor (IR) and insulin receptor substrate (IRS) proteins as well as phosphatidylinositol 3-kinase (PI3K) activation, and that this action is not due to the IL-1beta-dependent nitric oxide (NO) production in RINm5F cells. Nitric Oxide 266-278 interleukin 1 beta Rattus norvegicus 13-21 15605246-4 2004 METHODS: Transcriptome analyses were performed on two phenotypes characterised as a glucagon-producing pre-beta-cell phenotype (NHI-glu), which matures to an IL-1beta-sensitive insulin-producing beta cell phenotype (NHI-ins). Glutamic Acid 84-87 interleukin 1 beta Rattus norvegicus 158-166 15604057-5 2004 Curcumin and sulfasalazine obviously suppressed the high expression of proinflammatory cytokine interleukin (IL)-1beta mRNA and increased the low expression of IL-10 mRNA in the colonic mucosa. Sulfasalazine 13-26 interleukin 1 beta Rattus norvegicus 96-118 15517615-7 2004 Diminished infiltration by MHC class II(+) inflammatory cells and low expression of TNF-alpha, IL-1beta, and RANTES mRNA were noted in eyes of NP-PEG-TAM-treated rats. Polyethylene Glycols 146-149 interleukin 1 beta Rattus norvegicus 95-103 15517615-7 2004 Diminished infiltration by MHC class II(+) inflammatory cells and low expression of TNF-alpha, IL-1beta, and RANTES mRNA were noted in eyes of NP-PEG-TAM-treated rats. Tamoxifen 150-153 interleukin 1 beta Rattus norvegicus 95-103 15571975-5 2004 The presence of Fluoro-Jade-B-positive degenerating neurons was associated with IL1-beta, NF-kappaB, and COX-2 proteins expression during status epilepticus but not during the latent period while neurons were still degenerating. fluoro jade 16-29 interleukin 1 beta Rattus norvegicus 80-88 15302895-7 2004 Valsartan treatment preserved renal structure, by preventing the infiltration of inflammatory cells, and lowered renal expression of monocyte chemoattractant protein-1, transforming growth factor-beta1, and interleukin-1beta, compared with vehicle-treated SHRSP. Valsartan 0-9 interleukin 1 beta Rattus norvegicus 207-224 15613743-13 2004 ASA and rofecoxib, that significantly suppressed the mucosal prostaglandin (PG) E(2) generation in ulcer area, delayed significantly the rate of ulcer healing and decreased the GBF at ulcer margin, while elevating plasma IL-1beta, TNF-alpha and IL-10 concentrations in non-diabetic rats and these alterations were significantly augmented in diabetic animals. Aspirin 0-3 interleukin 1 beta Rattus norvegicus 221-229 15613743-13 2004 ASA and rofecoxib, that significantly suppressed the mucosal prostaglandin (PG) E(2) generation in ulcer area, delayed significantly the rate of ulcer healing and decreased the GBF at ulcer margin, while elevating plasma IL-1beta, TNF-alpha and IL-10 concentrations in non-diabetic rats and these alterations were significantly augmented in diabetic animals. rofecoxib 8-17 interleukin 1 beta Rattus norvegicus 221-229 15613743-14 2004 In contrast to ASA, the treatment with NO-ASA failed to influence both, the ulcer healing and GBF at ulcer margin and significantly attenuated the plasma levels of IL-1beta, TNF-alpha and IL-10 as compared to those recorded in ASA- or rofecoxib-treated animals. Aspirin 42-45 interleukin 1 beta Rattus norvegicus 164-172 15613743-14 2004 In contrast to ASA, the treatment with NO-ASA failed to influence both, the ulcer healing and GBF at ulcer margin and significantly attenuated the plasma levels of IL-1beta, TNF-alpha and IL-10 as compared to those recorded in ASA- or rofecoxib-treated animals. Aspirin 42-45 interleukin 1 beta Rattus norvegicus 164-172 15390122-5 2004 Expression of IL-1beta, TNF-alpha, and iNOS in ganglioside-treated cells was significantly reduced in the presence of inhibitors of PKC (GF109203X, Go6976, Ro31-8220, and rottlerin) and NADPH oxidase (diphenyleneiodonium chloride [DPI]). rottlerin 171-180 interleukin 1 beta Rattus norvegicus 14-22 15390122-4 2004 Our results show that gangliosides induce the expression of interleukin (IL)-1beta, tumor necrosis factor-alpha (TNF-alpha), and inducible nitric oxide synthase (iNOS) in rat brain microglia and BV2 murine microglia via protein kinase C (PKC) and NADPH oxidase. Gangliosides 22-34 interleukin 1 beta Rattus norvegicus 60-82 15390122-5 2004 Expression of IL-1beta, TNF-alpha, and iNOS in ganglioside-treated cells was significantly reduced in the presence of inhibitors of PKC (GF109203X, Go6976, Ro31-8220, and rottlerin) and NADPH oxidase (diphenyleneiodonium chloride [DPI]). Gangliosides 47-58 interleukin 1 beta Rattus norvegicus 14-22 15390122-5 2004 Expression of IL-1beta, TNF-alpha, and iNOS in ganglioside-treated cells was significantly reduced in the presence of inhibitors of PKC (GF109203X, Go6976, Ro31-8220, and rottlerin) and NADPH oxidase (diphenyleneiodonium chloride [DPI]). Go 6976 148-154 interleukin 1 beta Rattus norvegicus 14-22 15390122-5 2004 Expression of IL-1beta, TNF-alpha, and iNOS in ganglioside-treated cells was significantly reduced in the presence of inhibitors of PKC (GF109203X, Go6976, Ro31-8220, and rottlerin) and NADPH oxidase (diphenyleneiodonium chloride [DPI]). ro31 156-160 interleukin 1 beta Rattus norvegicus 14-22 15390122-5 2004 Expression of IL-1beta, TNF-alpha, and iNOS in ganglioside-treated cells was significantly reduced in the presence of inhibitors of PKC (GF109203X, Go6976, Ro31-8220, and rottlerin) and NADPH oxidase (diphenyleneiodonium chloride [DPI]). diphenyleneiodonium 201-229 interleukin 1 beta Rattus norvegicus 14-22 15390122-5 2004 Expression of IL-1beta, TNF-alpha, and iNOS in ganglioside-treated cells was significantly reduced in the presence of inhibitors of PKC (GF109203X, Go6976, Ro31-8220, and rottlerin) and NADPH oxidase (diphenyleneiodonium chloride [DPI]). diphenyleneiodonium 231-234 interleukin 1 beta Rattus norvegicus 14-22 15390122-9 2004 Furthermore, ganglioside-induced activation of NF-kappaB, an essential transcription factor that mediates the expression of IL-1beta, TNF-alpha, and iNOS, was reduced in the presence of GF109203X and DPI. Gangliosides 13-24 interleukin 1 beta Rattus norvegicus 124-132 15390122-9 2004 Furthermore, ganglioside-induced activation of NF-kappaB, an essential transcription factor that mediates the expression of IL-1beta, TNF-alpha, and iNOS, was reduced in the presence of GF109203X and DPI. bisindolylmaleimide I 186-195 interleukin 1 beta Rattus norvegicus 124-132 15390122-9 2004 Furthermore, ganglioside-induced activation of NF-kappaB, an essential transcription factor that mediates the expression of IL-1beta, TNF-alpha, and iNOS, was reduced in the presence of GF109203X and DPI. diphenyleneiodonium 200-203 interleukin 1 beta Rattus norvegicus 124-132 15519644-0 2004 Pirfenidone inhibits the induction of iNOS stimulated by interleukin-1beta at a step of NF-kappaB DNA binding in hepatocytes. pirfenidone 0-11 interleukin 1 beta Rattus norvegicus 57-74 15560787-0 2004 Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1beta-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids. Fatty Acids, Unsaturated 143-170 interleukin 1 beta Rattus norvegicus 78-95 15560787-3 2004 We have investigated the molecular mechanisms by which the incorporation of the n-6 PUFA, arachidonic acid, increases the proliferation of rat SMC treated with interleukin-1beta, while the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), elicit no mitogenic response. n-6 pufa 80-88 interleukin 1 beta Rattus norvegicus 160-177 15560787-3 2004 We have investigated the molecular mechanisms by which the incorporation of the n-6 PUFA, arachidonic acid, increases the proliferation of rat SMC treated with interleukin-1beta, while the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), elicit no mitogenic response. Arachidonic Acid 90-106 interleukin 1 beta Rattus norvegicus 160-177 15560787-4 2004 Incorporation of EPA or DHA into SMC, which are then activated by interleukin-1beta to mimic inflammation, decreases promoter activity of the cyclin D1 gene and phosphorylation of the retinoblastoma protein. Eicosapentaenoic Acid 17-20 interleukin 1 beta Rattus norvegicus 66-83 15560787-4 2004 Incorporation of EPA or DHA into SMC, which are then activated by interleukin-1beta to mimic inflammation, decreases promoter activity of the cyclin D1 gene and phosphorylation of the retinoblastoma protein. Docosahexaenoic Acids 24-27 interleukin 1 beta Rattus norvegicus 66-83 15505070-6 2004 IL-1beta also increased the levels of 8-hydroxy-2"-deoxyguanosine (an indicator of oxidative stress) and nitric oxide by more than 40% and activated NF-kappaB by 35% to 55%. 8-ohdg 38-65 interleukin 1 beta Rattus norvegicus 0-8 15505070-6 2004 IL-1beta also increased the levels of 8-hydroxy-2"-deoxyguanosine (an indicator of oxidative stress) and nitric oxide by more than 40% and activated NF-kappaB by 35% to 55%. Nitric Oxide 105-117 interleukin 1 beta Rattus norvegicus 0-8 15475176-4 2004 On the other hand, the gene expression of cholesterol 7alpha-hydroxylase (CYP7A1), a catabolic enzyme of cholesterol, was remarkably suppressed at 3-72 h. The gene expression levels of cytokines interleukin-1beta (IL-1beta) and TNF-alpha, which activate the HMGR gene and suppress the CYP7A1 gene, were significantly increased at 1-3 h and 3-24 h, respectively. Cholesterol 42-53 interleukin 1 beta Rattus norvegicus 195-212 15475176-4 2004 On the other hand, the gene expression of cholesterol 7alpha-hydroxylase (CYP7A1), a catabolic enzyme of cholesterol, was remarkably suppressed at 3-72 h. The gene expression levels of cytokines interleukin-1beta (IL-1beta) and TNF-alpha, which activate the HMGR gene and suppress the CYP7A1 gene, were significantly increased at 1-3 h and 3-24 h, respectively. Cholesterol 42-53 interleukin 1 beta Rattus norvegicus 214-222 15550091-5 2004 The production of TNF-alpha, interleukin (IL)-1beta, IL-6, and IL-10 was assessed after 4, 12 and 24 h. RESULTS: Lipopolysaccharide and zymosan stimulated TNF-alpha, IL-1beta, and IL-10 production; and peritoneal fluids from both control animals and animals with zymosan-induced peritonitis stimulated the production of TNF-alpha, IL-1RII, and IL-6. Zymosan 136-143 interleukin 1 beta Rattus norvegicus 29-51 15550091-5 2004 The production of TNF-alpha, interleukin (IL)-1beta, IL-6, and IL-10 was assessed after 4, 12 and 24 h. RESULTS: Lipopolysaccharide and zymosan stimulated TNF-alpha, IL-1beta, and IL-10 production; and peritoneal fluids from both control animals and animals with zymosan-induced peritonitis stimulated the production of TNF-alpha, IL-1RII, and IL-6. Zymosan 136-143 interleukin 1 beta Rattus norvegicus 166-174 15450943-0 2004 Inhibitory effects of epicatechin on interleukin-1beta-induced inducible nitric oxide synthase expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-kappaB activation. Catechin 22-33 interleukin 1 beta Rattus norvegicus 37-54 15450943-2 2004 Specifically, interleukin-1beta (IL-1beta) stimulates inducible nitric oxide synthase (iNOS) expression and nitric oxide overproduction, leading to the beta-cell damage. Nitric Oxide 64-76 interleukin 1 beta Rattus norvegicus 14-31 15450943-2 2004 Specifically, interleukin-1beta (IL-1beta) stimulates inducible nitric oxide synthase (iNOS) expression and nitric oxide overproduction, leading to the beta-cell damage. Nitric Oxide 64-76 interleukin 1 beta Rattus norvegicus 33-41 15450943-5 2004 In the present study, the effects of epicatechin on IL-1beta-induced beta-cell damage were examined. Catechin 37-48 interleukin 1 beta Rattus norvegicus 52-60 15450943-11 2004 Epicatechin significantly reduced IL-1beta-induced nitrite production, iNOS protein and mRNA expressions, and it also inhibited IL-1beta-induced IkappaBalpha protein degradation, NF-kappaB activation, and iNOS promoter activity. Catechin 0-11 interleukin 1 beta Rattus norvegicus 34-42 15450943-11 2004 Epicatechin significantly reduced IL-1beta-induced nitrite production, iNOS protein and mRNA expressions, and it also inhibited IL-1beta-induced IkappaBalpha protein degradation, NF-kappaB activation, and iNOS promoter activity. Catechin 0-11 interleukin 1 beta Rattus norvegicus 128-136 15450943-11 2004 Epicatechin significantly reduced IL-1beta-induced nitrite production, iNOS protein and mRNA expressions, and it also inhibited IL-1beta-induced IkappaBalpha protein degradation, NF-kappaB activation, and iNOS promoter activity. Nitrites 51-58 interleukin 1 beta Rattus norvegicus 34-42 15450943-12 2004 Epicatechin partly restored the IL-1beta-induced inhibition of insulin release. Catechin 0-11 interleukin 1 beta Rattus norvegicus 32-40 15450943-13 2004 These results suggest that epicatechin inhibits the IL-1beta-induced iNOS expression by down-regulating NF-kappaB activation, and protecting beta-cells from IL-1beta. Catechin 27-38 interleukin 1 beta Rattus norvegicus 52-60 15450943-13 2004 These results suggest that epicatechin inhibits the IL-1beta-induced iNOS expression by down-regulating NF-kappaB activation, and protecting beta-cells from IL-1beta. Catechin 27-38 interleukin 1 beta Rattus norvegicus 157-165 15505070-5 2004 RESULTS: The number of TUNEL-positive capillary cells in the retinal microvessels obtained from normal rats that received intravitreal injection of IL-1beta was increased by more than threefold and that of acellular capillaries by more than twofold, compared with the microvessels obtained from rats that received an intravitreal injection of PBS (5 microL) or BSA (5 ng/5 microL). Lead 343-346 interleukin 1 beta Rattus norvegicus 148-156 15519644-10 2004 Finally, pirfenidone inhibited the activation of Akt and up-regulation of IL-1 receptor stimulated by IL-1beta. pirfenidone 9-20 interleukin 1 beta Rattus norvegicus 102-110 15201138-2 2004 Western blot analysis indicated that IL-1beta treatment caused significant alterations in the redistribution of lamin B, specifically between the Triton X-100-soluble (membrane) and -insoluble (matrix) fractions of the nucleus. Octoxynol 146-158 interleukin 1 beta Rattus norvegicus 37-45 15389835-4 2004 Intraperitoneal pretreatment of pregnant female rats with NAC (50 mg/kg), 2 hr prior to administration of LPS at embryonic day 18 (E18), attenuated the LPS-induced expression of inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta, and inducible nitric oxide synthase in fetal rat brains. Acetylcysteine 58-61 interleukin 1 beta Rattus norvegicus 238-255 15656140-8 2004 Jasminoidin dramatically inhibited the increase of TNF-alpha and IL-1beta after 12 h and 24 h of ischemia, and repressed the increase of vWF after 12 h and 24 h of ischemia too. geniposide 0-11 interleukin 1 beta Rattus norvegicus 65-73 15656140-10 2004 CONCLUSION: Jasminoidin had good effect on repressing the expression of TNF-alpha and IL-1beta as well as vWF caused by cerebral ischemia, thus it manifested the effect of relieving the damage to vascular endothelial cell and blocking the progress of cascade damage of cerebral ischemia through inhibiting the process of inflammation. geniposide 12-23 interleukin 1 beta Rattus norvegicus 86-94 15498105-7 2004 In indomethacin treated rats, the volume of pleural exudate was low, its content in leukocytes and its contents in TNF-alpha, IL-1beta, IL-6 and IL-10 but not in NOx were reduced. Indomethacin 3-15 interleukin 1 beta Rattus norvegicus 126-134 15450110-0 2004 The stimulatory effect of alpha-melanotropin on progesterone release from rat granulosa cells is inhibited by interleukin-1beta and by tumour necrosis factor-alpha. Progesterone 48-60 interleukin 1 beta Rattus norvegicus 110-127 15450110-2 2004 In this work we study whether the administration of peptide alpha-melanotropin and the cytokines interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) on their own modify the release of progesterone in cultured granulosa cells (GC) from pro-oestrous rats. Progesterone 206-218 interleukin 1 beta Rattus norvegicus 97-114 15450110-2 2004 In this work we study whether the administration of peptide alpha-melanotropin and the cytokines interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) on their own modify the release of progesterone in cultured granulosa cells (GC) from pro-oestrous rats. Progesterone 206-218 interleukin 1 beta Rattus norvegicus 116-124 15450110-8 2004 However, when interleukin-1beta or TNF-alpha were added simultaneously with 1 microm alpha-melanotropin, a significant reduction (P < 0.01 for interleukin-1beta and P < 0.05 for TNF-alpha) of the steroid release was found with respect to the alpha-melanotropin-treated group. Steroids 202-209 interleukin 1 beta Rattus norvegicus 14-31 15205185-11 2004 IL-1beta and cyclooxygenase-2 mRNA were significantly upregulated in the hypothalamus of poly I:C-treated animals. Poly I-C 89-97 interleukin 1 beta Rattus norvegicus 0-8 15201138-7 2004 N(G)-monomethyl-l-arginine, a known inhibitor of inducible nitric oxide synthetase (iNOS), markedly inhibited IL-1beta-induced iNOS gene expression, NO release, caspase-3 and caspase-6 activation, lamin B degradation, and loss of metabolic cell viability, indicating that the observed IL-1beta-induced effects on nuclear lamin B involve the intermediacy of NO. omega-N-Methylarginine 0-26 interleukin 1 beta Rattus norvegicus 110-118 15201138-7 2004 N(G)-monomethyl-l-arginine, a known inhibitor of inducible nitric oxide synthetase (iNOS), markedly inhibited IL-1beta-induced iNOS gene expression, NO release, caspase-3 and caspase-6 activation, lamin B degradation, and loss of metabolic cell viability, indicating that the observed IL-1beta-induced effects on nuclear lamin B involve the intermediacy of NO. omega-N-Methylarginine 0-26 interleukin 1 beta Rattus norvegicus 285-293 15605983-5 2004 Our results demonstrate that chronic ethanol treatment up-regulates iNOS, COX-2 and IL-1beta in rat cerebral cortex and in cultured astrocytes. Ethanol 37-44 interleukin 1 beta Rattus norvegicus 84-92 15367215-7 2004 Molsidomine prevented an I-R-induced increase in superoxide anion and reduced plasma levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IFN-gamma), whereas it enhanced anti-inflammatory cytokines (IL-6 and IL-10). Molsidomine 0-11 interleukin 1 beta Rattus norvegicus 134-142 15367215-7 2004 Molsidomine prevented an I-R-induced increase in superoxide anion and reduced plasma levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IFN-gamma), whereas it enhanced anti-inflammatory cytokines (IL-6 and IL-10). i-r 25-28 interleukin 1 beta Rattus norvegicus 134-142 19641722-6 2004 There were significantly fewer myocardial interleukin-1beta-positive cells in rats with EAM treated with MCI-186 (at 3 mg/kg/day and 10 mg/kg/day) than in the untreated rats with EAM. molibresib 88-91 interleukin 1 beta Rattus norvegicus 42-59 19641722-6 2004 There were significantly fewer myocardial interleukin-1beta-positive cells in rats with EAM treated with MCI-186 (at 3 mg/kg/day and 10 mg/kg/day) than in the untreated rats with EAM. Edaravone 105-112 interleukin 1 beta Rattus norvegicus 42-59 15525583-4 2004 Rat islets treated with a cytokine combination (interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma) displayed a significant increase in islet cell apoptosis when the islets were incubated in 24.4 mM glucose compared with untreated islets at the same glucose concentration (13.07 +/- 1.78% vs 6.09 +/- 0.78%; P < 0.01) or islets incubated in 5.5 mM glucose concentration and cytokines (13.07 +/- 1.78% vs 8.04 +/- 1.56%; P < 0.05). Glucose 284-291 interleukin 1 beta Rattus norvegicus 48-70 15380490-2 2004 This study examined the changes in expression of the proinflammatory cytokines IL-1beta and TNF-alpha after progesterone (8 mg/kg) or allopregnanolone (4 mg/kg) treatment in brain-injured rats at 3, 8, and 12 h and 6 days post-injury. Progesterone 108-120 interleukin 1 beta Rattus norvegicus 79-87 15380490-2 2004 This study examined the changes in expression of the proinflammatory cytokines IL-1beta and TNF-alpha after progesterone (8 mg/kg) or allopregnanolone (4 mg/kg) treatment in brain-injured rats at 3, 8, and 12 h and 6 days post-injury. Pregnanolone 134-150 interleukin 1 beta Rattus norvegicus 79-87 15380490-7 2004 The results indicated that progesterone and allopregnanolone reduce both IL-1beta and TNF-alpha at 3 h post-injury, when the expression of these cytokines peaks. Progesterone 27-39 interleukin 1 beta Rattus norvegicus 73-81 15380490-7 2004 The results indicated that progesterone and allopregnanolone reduce both IL-1beta and TNF-alpha at 3 h post-injury, when the expression of these cytokines peaks. Pregnanolone 44-60 interleukin 1 beta Rattus norvegicus 73-81 15379883-1 2004 Eicosapentaenoic acid (EPA) protects hippocampus from age-related and irradiation-induced changes that lead to impairment in synaptic function; the evidence suggests that this is due to its anti-inflammatory effects, specifically preventing changes induced by the proinflammatory cytokine, interleukin-1beta (IL-1beta). Eicosapentaenoic Acid 0-21 interleukin 1 beta Rattus norvegicus 290-307 15525583-4 2004 Rat islets treated with a cytokine combination (interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma) displayed a significant increase in islet cell apoptosis when the islets were incubated in 24.4 mM glucose compared with untreated islets at the same glucose concentration (13.07 +/- 1.78% vs 6.09 +/- 0.78%; P < 0.01) or islets incubated in 5.5 mM glucose concentration and cytokines (13.07 +/- 1.78% vs 8.04 +/- 1.56%; P < 0.05). Glucose 233-240 interleukin 1 beta Rattus norvegicus 48-70 15525583-4 2004 Rat islets treated with a cytokine combination (interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma) displayed a significant increase in islet cell apoptosis when the islets were incubated in 24.4 mM glucose compared with untreated islets at the same glucose concentration (13.07 +/- 1.78% vs 6.09 +/- 0.78%; P < 0.01) or islets incubated in 5.5 mM glucose concentration and cytokines (13.07 +/- 1.78% vs 8.04 +/- 1.56%; P < 0.05). Glucose 284-291 interleukin 1 beta Rattus norvegicus 48-70 15379883-1 2004 Eicosapentaenoic acid (EPA) protects hippocampus from age-related and irradiation-induced changes that lead to impairment in synaptic function; the evidence suggests that this is due to its anti-inflammatory effects, specifically preventing changes induced by the proinflammatory cytokine, interleukin-1beta (IL-1beta). Eicosapentaenoic Acid 0-21 interleukin 1 beta Rattus norvegicus 309-317 15379883-1 2004 Eicosapentaenoic acid (EPA) protects hippocampus from age-related and irradiation-induced changes that lead to impairment in synaptic function; the evidence suggests that this is due to its anti-inflammatory effects, specifically preventing changes induced by the proinflammatory cytokine, interleukin-1beta (IL-1beta). Eicosapentaenoic Acid 23-26 interleukin 1 beta Rattus norvegicus 290-307 15379883-1 2004 Eicosapentaenoic acid (EPA) protects hippocampus from age-related and irradiation-induced changes that lead to impairment in synaptic function; the evidence suggests that this is due to its anti-inflammatory effects, specifically preventing changes induced by the proinflammatory cytokine, interleukin-1beta (IL-1beta). Eicosapentaenoic Acid 23-26 interleukin 1 beta Rattus norvegicus 309-317 15612528-8 2004 In the control group injected with saline solution, mRNA expressions of iNOS, IL-1beta, TNF-alpha and MnSOD were absent. Sodium Chloride 35-41 interleukin 1 beta Rattus norvegicus 78-86 15380328-1 2004 We investigated the role of IL-1alpha and IL-1beta expressed in the reactive gliosis following hippocampal damage induced by trimethyltin (TMT). trimethyltin 125-137 interleukin 1 beta Rattus norvegicus 42-50 15380328-1 2004 We investigated the role of IL-1alpha and IL-1beta expressed in the reactive gliosis following hippocampal damage induced by trimethyltin (TMT). trimethyltin 139-142 interleukin 1 beta Rattus norvegicus 42-50 15377890-6 2004 Mortality was recorded within 24 h. Bicuculline methiodide potently decreased the production of tumor necrosis factor-alpha and interleukin-1beta but increased interleukin-10 in serum. bicuculline methiodide 36-58 interleukin 1 beta Rattus norvegicus 128-145 15612528-17 2004 However, only SOD + CAT and vitamin C inhibited the mRNA expression of IL-1beta. Ascorbic Acid 28-37 interleukin 1 beta Rattus norvegicus 71-79 15341531-4 2004 In accordance with these findings, IL-1beta stimulated phosphorylation of p42/p44 MAPK, p38, and c-Jun N-terminal kinase (JNK), which was attenuated by U0126, SB202190, or SP600125, respectively. U 0126 152-157 interleukin 1 beta Rattus norvegicus 35-43 15331536-7 2004 The observed higher rate of cell death after exposure to a cytokine mixture in comparison with the weaker effect of IL-1beta alone may be due to an additive toxicity of TNF-alpha through ROS formation in mitochondria. Reactive Oxygen Species 187-190 interleukin 1 beta Rattus norvegicus 116-124 15341531-6 2004 Consistently, IL-1beta-stimulated translocation of NF-kappaB into the nucleus and degradation of inhibitory kappa B-alpha (IkappaB-alpha) was revealed by western blotting and immunofluorescence staining, which was blocked by helenalin, but not by U0126, SB202190, or SP600125. U 0126 247-252 interleukin 1 beta Rattus norvegicus 14-22 15341531-4 2004 In accordance with these findings, IL-1beta stimulated phosphorylation of p42/p44 MAPK, p38, and c-Jun N-terminal kinase (JNK), which was attenuated by U0126, SB202190, or SP600125, respectively. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 159-167 interleukin 1 beta Rattus norvegicus 35-43 15341531-6 2004 Consistently, IL-1beta-stimulated translocation of NF-kappaB into the nucleus and degradation of inhibitory kappa B-alpha (IkappaB-alpha) was revealed by western blotting and immunofluorescence staining, which was blocked by helenalin, but not by U0126, SB202190, or SP600125. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 254-262 interleukin 1 beta Rattus norvegicus 14-22 15341531-6 2004 Consistently, IL-1beta-stimulated translocation of NF-kappaB into the nucleus and degradation of inhibitory kappa B-alpha (IkappaB-alpha) was revealed by western blotting and immunofluorescence staining, which was blocked by helenalin, but not by U0126, SB202190, or SP600125. pyrazolanthrone 267-275 interleukin 1 beta Rattus norvegicus 14-22 15341531-4 2004 In accordance with these findings, IL-1beta stimulated phosphorylation of p42/p44 MAPK, p38, and c-Jun N-terminal kinase (JNK), which was attenuated by U0126, SB202190, or SP600125, respectively. pyrazolanthrone 172-180 interleukin 1 beta Rattus norvegicus 35-43 15341531-6 2004 Consistently, IL-1beta-stimulated translocation of NF-kappaB into the nucleus and degradation of inhibitory kappa B-alpha (IkappaB-alpha) was revealed by western blotting and immunofluorescence staining, which was blocked by helenalin, but not by U0126, SB202190, or SP600125. helenalin 225-234 interleukin 1 beta Rattus norvegicus 14-22 15591644-0 2004 Flupentixol and trifluperidol reduce interleukin-1 beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Flupenthixol 0-11 interleukin 1 beta Rattus norvegicus 37-55 15201401-4 2004 IL-1beta induced apoptotic cell death in the rat brain 24 h after the injection, as indicated by increases in positive TUNEL staining and caspase-3 activity, and apoptotic cell death was partially blocked by systemic administration of NBQX, an antagonist of the AMPA glutamate receptor. 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline 235-239 interleukin 1 beta Rattus norvegicus 0-8 15591644-0 2004 Flupentixol and trifluperidol reduce interleukin-1 beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Trifluperidol 16-29 interleukin 1 beta Rattus norvegicus 37-55 15591644-7 2004 Flupentixol at 20 and 2 muM reduced IL-1beta by mixed glial cell cultures after 3 days of exposure. Flupenthixol 0-11 interleukin 1 beta Rattus norvegicus 36-44 15591644-8 2004 Flupentixol at 20, 2 and 0.2 muM caused diminution of IL-1beta release after 1 day of exposure. Flupenthixol 0-11 interleukin 1 beta Rattus norvegicus 54-62 15591644-11 2004 Flupentixol at 20, 10, 2 and 0.2 muM reduced IL-1beta release by microgial cell cultures. Flupenthixol 0-11 interleukin 1 beta Rattus norvegicus 45-53 15300591-11 2004 Biliverdin treatment (1) led to a significant decrease in mRNA expression of iNOS, Cox-2, and ICAM-1 as well as the inflammatory cytokines IL-6 and IL-1beta; (2) decreased neutrophil infiltration into the jejunal muscularis; and (3) prevented SITx-induced suppression of intestinal circular muscle contractility. Biliverdine 0-10 interleukin 1 beta Rattus norvegicus 148-156 15304320-0 2004 15-Deoxy-delta(12,14)-prostaglandin J(2) inhibits IL-1beta-induced IKK enzymatic activity and IkappaBalpha degradation in rat chondrocytes through a PPARgamma-independent pathway. 15-deoxy-delta(12,14)-prostaglandin j 0-37 interleukin 1 beta Rattus norvegicus 50-58 15304320-3 2004 We previously demonstrated that 15d-PGJ(2) was more potent than troglitazone to counteract IL-1beta effects on chondrocytes. 15d-pgj 32-39 interleukin 1 beta Rattus norvegicus 91-99 15304320-3 2004 We previously demonstrated that 15d-PGJ(2) was more potent than troglitazone to counteract IL-1beta effects on chondrocytes. Troglitazone 64-76 interleukin 1 beta Rattus norvegicus 91-99 15304320-4 2004 Here, we studied the action of 15d-PGJ(2) on intracellular targets in nuclear factor-kappaB (NF-kappaB) signalling pathway in IL-1beta treated rat chondrocytes. 15d-pgj 31-38 interleukin 1 beta Rattus norvegicus 126-134 15305869-6 2004 The D1 antagonist, SCH23390, and the D2 antagonist, sulpiride, both attenuated expression of Fos in the medial parvocellular hypothalamic paraventricular nucleus (mpPVN) corticotropin-releasing factor cells at the apex of the HPA axis, as well as in most extra-hypothalamic brain regions examined in response to interleukin-1 beta. SCH 23390 19-27 interleukin 1 beta Rattus norvegicus 312-330 15305869-6 2004 The D1 antagonist, SCH23390, and the D2 antagonist, sulpiride, both attenuated expression of Fos in the medial parvocellular hypothalamic paraventricular nucleus (mpPVN) corticotropin-releasing factor cells at the apex of the HPA axis, as well as in most extra-hypothalamic brain regions examined in response to interleukin-1 beta. Sulpiride 52-61 interleukin 1 beta Rattus norvegicus 312-330 15277202-6 2004 In contrast, epicardial phenol blocked MI-induced increases in hypothalamic TNF-alpha and IL-1beta without affecting increases in the plasma and heart. Phenol 24-30 interleukin 1 beta Rattus norvegicus 90-98 15273826-8 2004 Chronic SHR treatment with moxonidine (0, 60 and 120 microg kg(-1) h(-1), sc for 4 weeks) dose-dependently decreased blood pressure, resulted in reversal of LVH and decreased ventricular interleukin 1beta concentration after 4 weeks of treatment. moxonidine 27-37 interleukin 1 beta Rattus norvegicus 187-204 15350552-0 2004 Cycloprodigiosin up-regulates inducible nitric oxide synthase gene expression in hepatocytes stimulated by interleukin-1beta. cycloprodigiosin 0-16 interleukin 1 beta Rattus norvegicus 107-124 15265664-4 2004 UCB leads to an increase of extracellular glutamate and highly enhances the release of TNF-alpha and IL-1beta, while inhibiting the production of IL-6. ucb 0-3 interleukin 1 beta Rattus norvegicus 101-109 15056726-10 2004 SP600125 inhibited interleukin-1beta-induced JNK activity and activator protein-1 activation, but it did not affect the activation of extracellular-regulated kinase, p38 mitogen-activated protein kinase, and nuclear factor-kappaB. pyrazolanthrone 0-8 interleukin 1 beta Rattus norvegicus 19-36 15350552-4 2004 This study investigated whether cycloprodigiosin influenced NF-kappaB activation and induction of iNOS by interleukin-1beta. cycloprodigiosin 32-48 interleukin 1 beta Rattus norvegicus 106-123 15350552-6 2004 Simultaneous addition of cycloprodigiosin and interleukin-1beta markedly stimulated the induction of iNOS mRNA and protein compared with addition of interleukin-1beta alone, resulting in overproduction of NO. cycloprodigiosin 25-41 interleukin 1 beta Rattus norvegicus 149-166 15229242-5 2004 Silencing of GalT-2 gene with the use of antisense oligonucleotides resulted in decreased LPS/IFN-gamma-induced iNOS, TNF-alpha, and IL-1beta gene expression. Oligonucleotides 51-67 interleukin 1 beta Rattus norvegicus 133-141 15223378-1 2004 The effect of the pro-inflammatory cytokine interleukin-1beta (IL-1beta) on the inducible nitric oxide synthase-nitric oxide (iNOS-NO) cascade in nociceptive signal transduction was examined in the intact rat spinal cord. Nitric Oxide 90-102 interleukin 1 beta Rattus norvegicus 44-61 15223378-1 2004 The effect of the pro-inflammatory cytokine interleukin-1beta (IL-1beta) on the inducible nitric oxide synthase-nitric oxide (iNOS-NO) cascade in nociceptive signal transduction was examined in the intact rat spinal cord. Nitric Oxide 90-102 interleukin 1 beta Rattus norvegicus 63-71 15237969-5 2004 EGCG inhibited CINC-1 production by IL-1beta-stimulated rat fibroblasts (NRK-49F cells) and lipopolysaccharide-stimulated rat macrophages at the concentration over 50 microg/mL, a comparatively high concentration. epigallocatechin gallate 0-4 interleukin 1 beta Rattus norvegicus 36-44 15196245-6 2004 Prednisolone reduced joint swelling through a mechanism associated with a reduction in IL-1beta and IL-6 protein and mRNA expression levels. Prednisolone 0-12 interleukin 1 beta Rattus norvegicus 87-95 15191814-0 2004 Modulation of IL-1 beta gene expression by lipid peroxidation inhibition after kainic acid-induced rat brain injury. Kainic Acid 79-90 interleukin 1 beta Rattus norvegicus 14-23 15608364-9 2004 Testosterone applied alone or supplemented in testectomized animals produced the significant increment in plasma IL-1 beta levels as compared to the respective levels of this cytokine in placebo-control animals. Testosterone 0-12 interleukin 1 beta Rattus norvegicus 113-122 15246743-0 2004 Protective effect of retinoic acid on interleukin-1 beta-induced cytotoxicity of pancreatic beta-cells. Tretinoin 21-34 interleukin 1 beta Rattus norvegicus 38-56 15165704-5 2004 Significantly, treatment of aged rats with eicosapentaenoic acid reversed the age-related increases in IL-1beta and IL-1beta-induced signalling and also the age-related changes in IL-4, ERK and PI-3 kinase. Eicosapentaenoic Acid 43-64 interleukin 1 beta Rattus norvegicus 103-111 15165704-5 2004 Significantly, treatment of aged rats with eicosapentaenoic acid reversed the age-related increases in IL-1beta and IL-1beta-induced signalling and also the age-related changes in IL-4, ERK and PI-3 kinase. Eicosapentaenoic Acid 43-64 interleukin 1 beta Rattus norvegicus 116-124 15110927-7 2004 Chronic tianeptine treatment attenuated LPS-induced expression of TNF-alpha in the spleen as well as plasma levels of this cytokine and altered the central balance between pro- and anti-inflammatory cytokines (IL-1 beta/IL-10). tianeptine 8-18 interleukin 1 beta Rattus norvegicus 210-219 15207038-4 2004 Ketamine/xylazine, chloral hydrate, and pentobarbital enhanced the basal expression of IL-1beta and IL-6 mRNA in rat spleen, while urethane reduced splenic IL-1beta mRNA expression. Ketamine 0-8 interleukin 1 beta Rattus norvegicus 87-95 15207038-4 2004 Ketamine/xylazine, chloral hydrate, and pentobarbital enhanced the basal expression of IL-1beta and IL-6 mRNA in rat spleen, while urethane reduced splenic IL-1beta mRNA expression. Ketamine 0-8 interleukin 1 beta Rattus norvegicus 156-164 15207038-4 2004 Ketamine/xylazine, chloral hydrate, and pentobarbital enhanced the basal expression of IL-1beta and IL-6 mRNA in rat spleen, while urethane reduced splenic IL-1beta mRNA expression. Xylazine 9-17 interleukin 1 beta Rattus norvegicus 87-95 15207038-4 2004 Ketamine/xylazine, chloral hydrate, and pentobarbital enhanced the basal expression of IL-1beta and IL-6 mRNA in rat spleen, while urethane reduced splenic IL-1beta mRNA expression. Xylazine 9-17 interleukin 1 beta Rattus norvegicus 156-164 15207038-4 2004 Ketamine/xylazine, chloral hydrate, and pentobarbital enhanced the basal expression of IL-1beta and IL-6 mRNA in rat spleen, while urethane reduced splenic IL-1beta mRNA expression. Chloral Hydrate 19-34 interleukin 1 beta Rattus norvegicus 87-95 15207038-4 2004 Ketamine/xylazine, chloral hydrate, and pentobarbital enhanced the basal expression of IL-1beta and IL-6 mRNA in rat spleen, while urethane reduced splenic IL-1beta mRNA expression. Chloral Hydrate 19-34 interleukin 1 beta Rattus norvegicus 156-164 15207038-4 2004 Ketamine/xylazine, chloral hydrate, and pentobarbital enhanced the basal expression of IL-1beta and IL-6 mRNA in rat spleen, while urethane reduced splenic IL-1beta mRNA expression. Pentobarbital 40-53 interleukin 1 beta Rattus norvegicus 87-95 15207038-4 2004 Ketamine/xylazine, chloral hydrate, and pentobarbital enhanced the basal expression of IL-1beta and IL-6 mRNA in rat spleen, while urethane reduced splenic IL-1beta mRNA expression. Pentobarbital 40-53 interleukin 1 beta Rattus norvegicus 156-164 15207038-4 2004 Ketamine/xylazine, chloral hydrate, and pentobarbital enhanced the basal expression of IL-1beta and IL-6 mRNA in rat spleen, while urethane reduced splenic IL-1beta mRNA expression. Urethane 131-139 interleukin 1 beta Rattus norvegicus 156-164 15246588-4 2004 Blood levels of TNF-alpha, IL-1beta, IL-6, IL-10, INF-gamma and IL-1 receptor antagonist were significantly increased in LPS and PLV + LPS groups. lps 121-124 interleukin 1 beta Rattus norvegicus 27-35 15246588-7 2004 Other cytokine mRNA expression including IL-10 and IL-1beta was also potentiated in PLV + LPS group, however this was not significant. lps 90-93 interleukin 1 beta Rattus norvegicus 51-59 15285793-0 2004 Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1beta production. Norepinephrine 51-65 interleukin 1 beta Rattus norvegicus 95-112 15172111-0 2004 Interleukin-1beta up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis. Iron 31-35 interleukin 1 beta Rattus norvegicus 0-17 15147833-6 2004 Males did not differ significantly from females in serum ALT values or pathology despite greater elevations in TNFalpha and IL-1beta mRNAs in ethanol-treated female rat livers (p < 0.05). Ethanol 142-149 interleukin 1 beta Rattus norvegicus 124-132 15201075-10 2004 CONCLUSION: Pretreatment with anti-inflammatory dose of aspirin can provide protection against heat stroke in rats, which may be associated with the inhibition of elevation of plasma IL-1beta levels by aspirin. Aspirin 56-63 interleukin 1 beta Rattus norvegicus 183-191 15201075-10 2004 CONCLUSION: Pretreatment with anti-inflammatory dose of aspirin can provide protection against heat stroke in rats, which may be associated with the inhibition of elevation of plasma IL-1beta levels by aspirin. Aspirin 202-209 interleukin 1 beta Rattus norvegicus 183-191 15060086-0 2004 Omega-3 fatty acid ethyl-eicosapentaenoate, but not soybean oil, attenuates memory impairment induced by central IL-1beta administration. Fatty Acids, Omega-3 0-18 interleukin 1 beta Rattus norvegicus 113-121 15309881-7 2004 On inflamed mucosa, celecoxib augmented enzymatic activity at the lower dose, which was parallelled by an increase in the interleukin 1beta level. Celecoxib 20-29 interleukin 1 beta Rattus norvegicus 122-139 15120750-5 2004 In addition, BHA markedly attenuated the production of proinflammatory cytokines IL-1beta and TNF-alpha by both islets of pancreas and peritoneal macrophages. Butylated Hydroxyanisole 13-16 interleukin 1 beta Rattus norvegicus 81-89 15060086-8 2004 IL-1beta also caused an increase in the hippocampal PGE2 concentration. Dinoprostone 52-56 interleukin 1 beta Rattus norvegicus 0-8 15060086-0 2004 Omega-3 fatty acid ethyl-eicosapentaenoate, but not soybean oil, attenuates memory impairment induced by central IL-1beta administration. eicosapentaenoic acid ethyl ester 19-42 interleukin 1 beta Rattus norvegicus 113-121 15060086-2 2004 IL-1beta has also been shown to increase the concentration of the inflammatory mediator prostaglandin E2 (PGE2) in the blood. Dinoprostone 88-104 interleukin 1 beta Rattus norvegicus 0-8 15060086-2 2004 IL-1beta has also been shown to increase the concentration of the inflammatory mediator prostaglandin E2 (PGE2) in the blood. Dinoprostone 106-110 interleukin 1 beta Rattus norvegicus 0-8 15060086-4 2004 The purpose of this study was to determine whether dietary supplements of EPA would attenuate the inflammation-induced impairment of spatial memory by centrally administered IL-1beta. Eicosapentaenoic Acid 74-77 interleukin 1 beta Rattus norvegicus 174-182 15189347-0 2004 3,4-Methylenedioxymethamphetamine increases interleukin-1beta levels and activates microglia in rat brain: studies on the relationship with acute hyperthermia and 5-HT depletion. N-Methyl-3,4-methylenedioxyamphetamine 0-33 interleukin 1 beta Rattus norvegicus 44-61 15145601-0 2004 Potent effect of interleukin-1 beta to evoke ATP and adenosine release from rat hippocampal slices. Adenosine Triphosphate 45-48 interleukin 1 beta Rattus norvegicus 17-35 15145601-0 2004 Potent effect of interleukin-1 beta to evoke ATP and adenosine release from rat hippocampal slices. Adenosine 53-62 interleukin 1 beta Rattus norvegicus 17-35 15145601-1 2004 In this study the effect of IL-1 beta on [(3)H]purine release from rat hippocampal slices was explored. [(3)h]purine 41-53 interleukin 1 beta Rattus norvegicus 28-37 15145601-2 2004 IL-1 beta (3 x 10(-18)-3 x 10(-14) M) concentration-dependently elevated the basal [(3)H]purine efflux, and this effect was reversed by the selective IL-1RI receptor antagonist IL-1ra (10(-12) M). purine 89-95 interleukin 1 beta Rattus norvegicus 0-9 15145601-3 2004 HPLC analysis revealed that the amount of [(3)H]ATP and [(3)H]adenosine significantly increased in the effluent in response to IL-1 beta. [(3)h]atp 42-51 interleukin 1 beta Rattus norvegicus 127-136 15145601-3 2004 HPLC analysis revealed that the amount of [(3)H]ATP and [(3)H]adenosine significantly increased in the effluent in response to IL-1 beta. [(3)h]adenosine 56-71 interleukin 1 beta Rattus norvegicus 127-136 15145601-5 2004 The effect of IL-1 beta on [(3)H]purine efflux was also prevented by the p38 MAP kinase inhibitor SB 203580, by the nucleoside transport inhibitor nitrobenzyl-thioinosine (NBTI) and by low temperature (4 degrees C). [(3)h]purine 27-39 interleukin 1 beta Rattus norvegicus 14-23 15145601-5 2004 The effect of IL-1 beta on [(3)H]purine efflux was also prevented by the p38 MAP kinase inhibitor SB 203580, by the nucleoside transport inhibitor nitrobenzyl-thioinosine (NBTI) and by low temperature (4 degrees C). SB 203580 98-107 interleukin 1 beta Rattus norvegicus 14-23 15145601-5 2004 The effect of IL-1 beta on [(3)H]purine efflux was also prevented by the p38 MAP kinase inhibitor SB 203580, by the nucleoside transport inhibitor nitrobenzyl-thioinosine (NBTI) and by low temperature (4 degrees C). 4-nitrobenzylthioinosine 147-170 interleukin 1 beta Rattus norvegicus 14-23 15145601-5 2004 The effect of IL-1 beta on [(3)H]purine efflux was also prevented by the p38 MAP kinase inhibitor SB 203580, by the nucleoside transport inhibitor nitrobenzyl-thioinosine (NBTI) and by low temperature (4 degrees C). 4-nitrobenzylthioinosine 172-176 interleukin 1 beta Rattus norvegicus 14-23 15145601-6 2004 In summary IL-1 beta triggers a transporter mediated [(3)H]purine efflux in the hippocampus which is conveyed by glutamate receptor activation and the p38 MAP kinase pathway, and could serve as a mediator of IL-1 beta-induced synaptic depression. purine 59-65 interleukin 1 beta Rattus norvegicus 11-20 15145601-6 2004 In summary IL-1 beta triggers a transporter mediated [(3)H]purine efflux in the hippocampus which is conveyed by glutamate receptor activation and the p38 MAP kinase pathway, and could serve as a mediator of IL-1 beta-induced synaptic depression. purine 59-65 interleukin 1 beta Rattus norvegicus 208-217 15189347-4 2004 MDMA, given to rats housed at 22 degrees C, increased IL-1beta levels in hypothalamus and cortex from 1 to 6 h and [(3)H]-(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)3-isoquinolinecarboxamide) binding between 3 and 48 h. Increased immunoreactivity to OX-42 was also detected. N-Methyl-3,4-methylenedioxyamphetamine 0-4 interleukin 1 beta Rattus norvegicus 54-62 15189347-7 2004 When MDMA was given to rats housed at 4 degrees C, hyperthermia was abolished and the IL-1beta increase significantly reduced. N-Methyl-3,4-methylenedioxyamphetamine 5-9 interleukin 1 beta Rattus norvegicus 86-94 15111026-0 2004 Involvement of arachidonic acid cascade in working memory impairment induced by interleukin-1 beta. Arachidonic Acid 15-31 interleukin 1 beta Rattus norvegicus 80-98 15213357-11 2004 Administration of PTX significantly attenuated the gastric lesions, induced by 3.5 h of WRS and this was accompanied by the rise in the GBF and a significant decrease in plasma proinflammatory cytokines (IL-1beta and TNFalpha) levels, as well as the reduction of lipid peroxidation. Pentoxifylline 18-21 interleukin 1 beta Rattus norvegicus 204-212 14699427-0 2004 Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1beta in rats. icosapent 0-27 interleukin 1 beta Rattus norvegicus 126-143 14699427-0 2004 Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1beta in rats. Corticosterone 47-61 interleukin 1 beta Rattus norvegicus 126-143 14699427-1 2004 Central or peripheral administration of the proinflammatory cytokine interleukin (IL)-1beta can impair performance on spatial memory tasks and also elevate circulating concentration of corticosterone. Corticosterone 185-199 interleukin 1 beta Rattus norvegicus 69-91 14699427-3 2004 The probable involvement of corticosterone in IL-1beta-induced memory impairment was indicated by elevated corticosterone levels after IL-1beta administration. Corticosterone 28-42 interleukin 1 beta Rattus norvegicus 46-54 14699427-3 2004 The probable involvement of corticosterone in IL-1beta-induced memory impairment was indicated by elevated corticosterone levels after IL-1beta administration. Corticosterone 28-42 interleukin 1 beta Rattus norvegicus 135-143 14699427-3 2004 The probable involvement of corticosterone in IL-1beta-induced memory impairment was indicated by elevated corticosterone levels after IL-1beta administration. Corticosterone 107-121 interleukin 1 beta Rattus norvegicus 46-54 14699427-5 2004 Ingestion of diet containing omega-3 fatty acid eicosapentaenoic acid (EPA) is known to antagonize the synthesis of prostaglandin (PG) E2 from aracadonic acid, and the present study confirmed that ethyl EPA (1%) reduced IL-1beta-elevated concentrations of PGE2 and corticosterone. Fatty Acids, Omega-3 29-47 interleukin 1 beta Rattus norvegicus 220-228 14699427-5 2004 Ingestion of diet containing omega-3 fatty acid eicosapentaenoic acid (EPA) is known to antagonize the synthesis of prostaglandin (PG) E2 from aracadonic acid, and the present study confirmed that ethyl EPA (1%) reduced IL-1beta-elevated concentrations of PGE2 and corticosterone. Eicosapentaenoic Acid 48-69 interleukin 1 beta Rattus norvegicus 220-228 14699427-5 2004 Ingestion of diet containing omega-3 fatty acid eicosapentaenoic acid (EPA) is known to antagonize the synthesis of prostaglandin (PG) E2 from aracadonic acid, and the present study confirmed that ethyl EPA (1%) reduced IL-1beta-elevated concentrations of PGE2 and corticosterone. Eicosapentaenoic Acid 71-74 interleukin 1 beta Rattus norvegicus 220-228 14699427-5 2004 Ingestion of diet containing omega-3 fatty acid eicosapentaenoic acid (EPA) is known to antagonize the synthesis of prostaglandin (PG) E2 from aracadonic acid, and the present study confirmed that ethyl EPA (1%) reduced IL-1beta-elevated concentrations of PGE2 and corticosterone. Dinoprostone 116-137 interleukin 1 beta Rattus norvegicus 220-228 14699427-5 2004 Ingestion of diet containing omega-3 fatty acid eicosapentaenoic acid (EPA) is known to antagonize the synthesis of prostaglandin (PG) E2 from aracadonic acid, and the present study confirmed that ethyl EPA (1%) reduced IL-1beta-elevated concentrations of PGE2 and corticosterone. icosapent 197-206 interleukin 1 beta Rattus norvegicus 220-228 14699427-7 2004 IL-1beta-induced suppression of mitogen-stimulated release of the anti-inflammatory cytokine IL-10 was also blocked by treatment with ethyl-EPA. icosapent 134-143 interleukin 1 beta Rattus norvegicus 0-8 14699427-8 2004 Collectively, these data demonstrate that IL-1beta can impair memory function by elevating the concentration of corticosterone and that prior consumption of 1% ethyl-EPA can block both the neuroendocrine and cognitive effects of IL-1beta. Corticosterone 112-126 interleukin 1 beta Rattus norvegicus 42-50 14699427-8 2004 Collectively, these data demonstrate that IL-1beta can impair memory function by elevating the concentration of corticosterone and that prior consumption of 1% ethyl-EPA can block both the neuroendocrine and cognitive effects of IL-1beta. icosapent 160-169 interleukin 1 beta Rattus norvegicus 229-237 32585792-0 2004 Involvement of arachidonic acid cascade in working memory impairment induced by interleukin-1 beta. Arachidonic Acid 15-31 interleukin 1 beta Rattus norvegicus 80-98 32585792-2 2004 Interleukin-1 beta, injected bilaterally into the dorsal hippocampus at a dose of 100 ng/side, significantly impaired working memory, and this impairment was attenuated by pretreatment with 10 mg/kg (s.c.) of diclofenac, a cyclooxygenase inhibitor. Diclofenac 209-219 interleukin 1 beta Rattus norvegicus 0-18 32585792-4 2004 Furthermore, an injection of 100 ng/side of interleukin-1 beta significantly increased production of prostaglandin E2 (580+-32 pg to 1142+-101 pg/100 mg wet tissue) in the hippocampus. Dinoprostone 101-117 interleukin 1 beta Rattus norvegicus 44-62 32585792-5 2004 Taken together, these findings suggest that the activation of the arachidonic acid cascade was causative of the working memory impairment induced by interleukin-1 beta. Arachidonic Acid 66-82 interleukin 1 beta Rattus norvegicus 149-167 15111026-2 2004 Interleukin-1 beta, injected bilaterally into the dorsal hippocampus at a dose of 100 ng/side, significantly impaired working memory, and this impairment was attenuated by pretreatment with 10 mg/kg (s.c.) of diclofenac, a cyclooxygenase inhibitor. Diclofenac 209-219 interleukin 1 beta Rattus norvegicus 0-18 15111026-4 2004 Furthermore, an injection of 100 ng/side of interleukin-1 beta significantly increased production of prostaglandin E2 (580 +/- 32 pg to 1142 +/- 101 pg/100 mg wet tissue) in the hippocampus. Dinoprostone 101-117 interleukin 1 beta Rattus norvegicus 44-62 15111026-5 2004 Taken together, these findings suggest that the activation of the arachidonic acid cascade was causative of the working memory impairment induced by interleukin-1 beta. Arachidonic Acid 66-82 interleukin 1 beta Rattus norvegicus 149-167 16136957-10 2004 Moreover, the plasma TNF-alpha and IL-1beta levels of the rats of BZXD group were lower than those of the MTX group (P < 0. bzxd 66-70 interleukin 1 beta Rattus norvegicus 35-43 15266826-7 2004 Among the inhibitors of intracellular signaling transduction pathways, mitogen-activated protein kinases (MAPK) inhibitor PD98059 (40 micromol/L) and p38 MAPK inhibitor SB203580 (5 micromol/L) completely blocked the stimulatory effect of IL-1beta, and phosphoinositide 3-kinase (PI3-K) inhibitor LY294002 (10 micromol/L) partly blocked the induction of IL-1beta. SB 203580 169-177 interleukin 1 beta Rattus norvegicus 238-246 15266826-7 2004 Among the inhibitors of intracellular signaling transduction pathways, mitogen-activated protein kinases (MAPK) inhibitor PD98059 (40 micromol/L) and p38 MAPK inhibitor SB203580 (5 micromol/L) completely blocked the stimulatory effect of IL-1beta, and phosphoinositide 3-kinase (PI3-K) inhibitor LY294002 (10 micromol/L) partly blocked the induction of IL-1beta. SB 203580 169-177 interleukin 1 beta Rattus norvegicus 353-361 16136957-13 2004 Both BZXD and MTX can notably decrease the plasma TNF-alpha and IL-1beta levels, but the effect of BZXD is better than that of MTX. bzxd 5-9 interleukin 1 beta Rattus norvegicus 64-72 15706927-0 2004 [The influence of CGE on expression of IL-1beta and c-fos protein in the hippocampus region in rats following cerebral ischemia-reperfusion]. Clopidogrel 18-21 interleukin 1 beta Rattus norvegicus 39-47 16136957-13 2004 Both BZXD and MTX can notably decrease the plasma TNF-alpha and IL-1beta levels, but the effect of BZXD is better than that of MTX. Methotrexate 14-17 interleukin 1 beta Rattus norvegicus 64-72 15706927-1 2004 OBJECTIVE: To observe inhibiting effect of CGE (compound ginseng extract) on increased expression of IL-1beta and c-fos protein following cerebral ischemia-reperfusion. Clopidogrel 43-46 interleukin 1 beta Rattus norvegicus 101-109 15706927-8 2004 CGE inhibited the expression of hippocampus IL-1beta protein, taking effect from the 2 h after reperfusion. Clopidogrel 0-3 interleukin 1 beta Rattus norvegicus 44-52 14684367-7 2004 IL-1beta increased PGE2 but not PGI2 production and decreased vascular tone as measured in isolated cerebral arteries; the latter effect was partially reversed by treatment with the selective COX-2 inhibitor NS-398 (10 micromol/l). Dinoprostone 19-23 interleukin 1 beta Rattus norvegicus 0-8 16136957-1 2004 OBJECTIVE: To observe the influence of bizhongxiao decotion (BZXD) on the plasma TNF-alpha and IL-1beta in rats with C II-induced arthritis (CIA) and to explore the mechanism of BZXD in the treatment of rheumatoid arthritis. bzxd 61-65 interleukin 1 beta Rattus norvegicus 95-103 15239610-2 2004 In vitro, AGI-1096 inhibited the inducible expression of vascular cell adhesion molecule (VCAM)-1, E-selectin, and monocyte chemoattractant protein (MCP)-1 in endothelial cells and tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta secretion from lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells. elsibucol 10-18 interleukin 1 beta Rattus norvegicus 219-241 14684367-1 2004 Interleukin (IL)-1beta is a potent inducer of inflammatory prostaglandins, which are important mediators of vascular response to cerebral injury, whereas estrogen reduces brain injury in models of ischemic stroke. Prostaglandins 59-73 interleukin 1 beta Rattus norvegicus 0-22 14684367-7 2004 IL-1beta increased PGE2 but not PGI2 production and decreased vascular tone as measured in isolated cerebral arteries; the latter effect was partially reversed by treatment with the selective COX-2 inhibitor NS-398 (10 micromol/l). N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 208-214 interleukin 1 beta Rattus norvegicus 0-8 14684367-9 2004 Combined treatment with 17beta-estradiol and medroxyprogesterone acetate also prevented increases in PGE2 production after IL-1beta treatment, but treatment with 17alpha-estradiol had no effect. Estradiol 24-40 interleukin 1 beta Rattus norvegicus 123-131 15084165-5 2004 Inhibition of ET-1 action by a nonselective ET-1 receptor antagonist, bosentan, significantly decreased tracheal occlusion, which was linked to delayed epithelial necrosis, suppressed smooth muscle cell proliferation, and a marked reduction in the number of interleukin-1beta and interleukin-2 immunoreactive cells. Bosentan 70-78 interleukin 1 beta Rattus norvegicus 258-275 14684367-9 2004 Combined treatment with 17beta-estradiol and medroxyprogesterone acetate also prevented increases in PGE2 production after IL-1beta treatment, but treatment with 17alpha-estradiol had no effect. Medroxyprogesterone Acetate 45-72 interleukin 1 beta Rattus norvegicus 123-131 14684367-9 2004 Combined treatment with 17beta-estradiol and medroxyprogesterone acetate also prevented increases in PGE2 production after IL-1beta treatment, but treatment with 17alpha-estradiol had no effect. Dinoprostone 101-105 interleukin 1 beta Rattus norvegicus 123-131 14684367-10 2004 IL-1beta induction of COX-2 protein was prevented by treatment with the nuclear factor-kappaB inhibitor caffeic acid phenethyl ester (20 mg/kg i.p. caffeic acid phenethyl ester 104-132 interleukin 1 beta Rattus norvegicus 0-8 15143896-5 2004 Animals in the FR group received intraperitoneal FR167653, a selective inhibitor of TNF alpha and IL 1beta, while those in the Control group received vehicle only. FR 167653 49-57 interleukin 1 beta Rattus norvegicus 98-106 15097442-12 2004 CONCLUSIONS: The authors conclude that IL-1beta and TNF-alpha are involved in the spermine effects on maltase- and sucrase-specific activities and suggest that IL-2 is involved in the spermine-induced decrease of lactase activity. Spermine 184-192 interleukin 1 beta Rattus norvegicus 39-47 15097442-12 2004 CONCLUSIONS: The authors conclude that IL-1beta and TNF-alpha are involved in the spermine effects on maltase- and sucrase-specific activities and suggest that IL-2 is involved in the spermine-induced decrease of lactase activity. Spermine 82-90 interleukin 1 beta Rattus norvegicus 39-47 15105991-2 2004 We have previously shown that IL-1 beta modulates beta cell function, causes beta cell death and induces expression changes in 82 out of 1815 protein spots detected by two-dimensional gel electrophoresis (2-DGE) in diabetes-prone bio-breeding (BB-DP) rat islets in vitro. bb-dp 244-249 interleukin 1 beta Rattus norvegicus 30-39 15105991-11 2004 CONCLUSIONS/INTERPRETATION: IL-1 beta-induced protein expression changes in islets in vitro also occur in vivo and change in a complex pattern during the development of diabetes in the BB-DP rat. boeravinone B 185-187 interleukin 1 beta Rattus norvegicus 28-37 15105991-11 2004 CONCLUSIONS/INTERPRETATION: IL-1 beta-induced protein expression changes in islets in vitro also occur in vivo and change in a complex pattern during the development of diabetes in the BB-DP rat. dp 188-190 interleukin 1 beta Rattus norvegicus 28-37 15024756-1 2004 Interleukin-1 beta (IL-1 beta) is thought to act on the brain to induce fever, neuroendocrine activation, and behavioral changes during disease through induction of prostaglandins at the blood-brain barrier (BBB). Prostaglandins 165-179 interleukin 1 beta Rattus norvegicus 0-18 15063785-0 2004 IL-1beta and TNFalpha regulate sodium absorption in rat distal colon. Sodium 31-37 interleukin 1 beta Rattus norvegicus 0-8 15063785-9 2004 We conclude that the pro-inflammatory cytokines IL-1beta and TNFalpha inhibit electrogenic sodium absorption in rat distal colon by mRNA expression regulation of the beta- and gamma-ENaC subunits. Sodium 91-97 interleukin 1 beta Rattus norvegicus 48-56 15082173-0 2004 Interleukin-1 beta injected intracisternally inhibited NMDA-evoked behavioral response in the orofacial area of freely moving rats. N-Methylaspartate 55-59 interleukin 1 beta Rattus norvegicus 0-18 15082173-6 2004 The intracisternal injection of 1 or 10 ng IL-1beta significantly decreased the NMDA-evoked scratching behavioral responses. N-Methylaspartate 80-84 interleukin 1 beta Rattus norvegicus 43-51 15082173-7 2004 Pretreatment with an IL-1 receptor antagonist or naloxone, an opioid receptor antagonist, blocked the IL-1beta-induced antinociceptive response. Naloxone 49-57 interleukin 1 beta Rattus norvegicus 102-110 15024756-1 2004 Interleukin-1 beta (IL-1 beta) is thought to act on the brain to induce fever, neuroendocrine activation, and behavioral changes during disease through induction of prostaglandins at the blood-brain barrier (BBB). Prostaglandins 165-179 interleukin 1 beta Rattus norvegicus 20-29 15024756-2 2004 However, despite the fact that IL-1 beta induces the prostaglandin-synthesizing enzyme cyclooxygenase-2 (COX-2) in brain vascular cells, no study has established the presence of IL-1 receptor type 1 (IL-1R1) protein in these cells. Prostaglandins 53-66 interleukin 1 beta Rattus norvegicus 31-40 15020069-5 2004 Morphine also enhanced LPS-induced leukocyte-endothelial adhesion (LEA), suppressed leukocyte flux, and corticosterone production, and elevated interleukin-1beta, tumor necrosis factor-alpha, and interleukin-6 serum levels. Morphine 0-8 interleukin 1 beta Rattus norvegicus 144-190 15006904-11 2004 Our results indicate that BK, TNF-alpha, IL-1 beta, IL-6, IL-8, sympathetic amines and PGs (but not leukotrienes) contribute significantly to formalin-induced orofacial nociception in the rat and the response seems to be more susceptible to inhibition by B(2) receptor antagonist and selective COX-2 inhibitor than by B(1) receptor antagonist or nonselective COX inhibitor. Formaldehyde 142-150 interleukin 1 beta Rattus norvegicus 41-50 15087710-2 2004 In the present study, we show that in cultured leptomeningeal cells, IL-1beta, tumor necrosis factors, or lipopolysaccharide causes a prominent increase in the synthesis and release of prostaglandin (PG) D synthase, which catalyzes the final step in the biosynthesis of PGD2. Prostaglandin D2 270-274 interleukin 1 beta Rattus norvegicus 69-77 15087710-5 2004 Furthermore, we found that the increased secretion of PGD synthase by IL-1beta was completely inhibited by 10(-7) M PGE2. Dinoprostone 116-120 interleukin 1 beta Rattus norvegicus 70-78 15081310-5 2004 Inhibition of p38 MAP kinase with SB203580 abolished IL-1 beta- and TNF-alpha-stimulated increase in BNP mRNA, promoter activity and secretion. SB 203580 34-42 interleukin 1 beta Rattus norvegicus 53-62 15003285-8 2004 These results suggest that peripheral cytokine can produce mechanical allodynia in the orofacial area and that excitatory amino acids can modulate IL-1beta-induced mechanical allodynia via non-NMDA receptors. Excitatory Amino Acids 111-133 interleukin 1 beta Rattus norvegicus 147-155 15124927-6 2004 Myocardial interleukin (IL)- 1beta expression by western blotting and IL-1beta-positive staining cells by immunohistochemistry were significantly lower in rats with EAM given olmesartan treatment compared with those of rats given vehicle. molibresib 165-168 interleukin 1 beta Rattus norvegicus 70-78 15124927-6 2004 Myocardial interleukin (IL)- 1beta expression by western blotting and IL-1beta-positive staining cells by immunohistochemistry were significantly lower in rats with EAM given olmesartan treatment compared with those of rats given vehicle. olmesartan 175-185 interleukin 1 beta Rattus norvegicus 70-78 15164758-1 2004 Stimulation of rat mesangial cells for 24 h with interleukin-1beta (IL- 1beta) plus forskolin (Fk) leads to a marked increase in prostaglandin E2 (PGE2) synthesis. Dinoprostone 129-145 interleukin 1 beta Rattus norvegicus 49-66 15164758-1 2004 Stimulation of rat mesangial cells for 24 h with interleukin-1beta (IL- 1beta) plus forskolin (Fk) leads to a marked increase in prostaglandin E2 (PGE2) synthesis. Dinoprostone 129-145 interleukin 1 beta Rattus norvegicus 68-77 15164758-1 2004 Stimulation of rat mesangial cells for 24 h with interleukin-1beta (IL- 1beta) plus forskolin (Fk) leads to a marked increase in prostaglandin E2 (PGE2) synthesis. Dinoprostone 147-151 interleukin 1 beta Rattus norvegicus 49-66 15164758-1 2004 Stimulation of rat mesangial cells for 24 h with interleukin-1beta (IL- 1beta) plus forskolin (Fk) leads to a marked increase in prostaglandin E2 (PGE2) synthesis. Dinoprostone 147-151 interleukin 1 beta Rattus norvegicus 68-77 15164758-4 2004 In parallel to the increased PGE2 synthesis, a potentiation of IL-1beta-induced secretory group IIA phospholipases A2 (sPLA2-IIA) protein expression also occurs by Rho inhibition. Dinoprostone 29-33 interleukin 1 beta Rattus norvegicus 63-71 15164758-5 2004 However, only toxin A triggers an increased sPLA2-IIA activity consistent with the elevated levels of protein expression, whereas Y27632 and lovastatin rather reduced IL-1beta-induced sPLA2-IIA activity. Lovastatin 141-151 interleukin 1 beta Rattus norvegicus 167-175 14711797-6 2004 In newborns, the addition of 100% oxygen (O2) to 30 minutes of ventilation blunted the high VT induction of IL-1beta, IL-10, and MIP-2 mRNA expressions, whereas at 3 hours, 100% O2 concentration synergistically increased the mRNAs for TNF-alpha and IL-6. Oxygen 34-40 interleukin 1 beta Rattus norvegicus 108-116 14711797-6 2004 In newborns, the addition of 100% oxygen (O2) to 30 minutes of ventilation blunted the high VT induction of IL-1beta, IL-10, and MIP-2 mRNA expressions, whereas at 3 hours, 100% O2 concentration synergistically increased the mRNAs for TNF-alpha and IL-6. Oxygen 42-44 interleukin 1 beta Rattus norvegicus 108-116 15000880-0 2004 Brain IL-1 beta was involved in reserpine-induced behavioral depression in rats. Reserpine 32-41 interleukin 1 beta Rattus norvegicus 6-15 15000880-1 2004 AIM: To investigate the mechanism of brain interleukin-1 beta (IL-1 beta) in reserpine-induced behavioral depression in rats. Reserpine 77-86 interleukin 1 beta Rattus norvegicus 63-72 15000880-1 2004 AIM: To investigate the mechanism of brain interleukin-1 beta (IL-1 beta) in reserpine-induced behavioral depression in rats. Reserpine 77-86 interleukin 1 beta Rattus norvegicus 43-61 15036398-0 2004 Exaggerated production of nitric oxide (NO) and increases in inducible NO-synthase mRNA levels induced by the pro-inflammatory cytokine interleukin-1beta in vascular smooth muscle cells of elderly rats. Nitric Oxide 26-38 interleukin 1 beta Rattus norvegicus 136-153 15000880-4 2004 Intracerebroventricular injection (icv) of IL-1 beta receptor antagonist (IL-1ra, 6 mg/kg) blocked the increment of floating time in Porsult swim test at 48 and 72 h after reserpine injection, but not at 1 and 24 h after injection. Reserpine 172-181 interleukin 1 beta Rattus norvegicus 43-52 15000880-5 2004 Brain IL-1 beta increased after reserpine treatment in posterior cortex, hippocampus, and hypothalamus. Reserpine 32-41 interleukin 1 beta Rattus norvegicus 6-15 15000880-6 2004 The increase of IL-1 beta concentration starts at 24 hours after injection of reserpine and reached the peak at 48 h. CONCLUSION: Reserpine induced behavioral depression partially via brain interleukin-1 beta generation. Reserpine 78-87 interleukin 1 beta Rattus norvegicus 16-25 15000880-6 2004 The increase of IL-1 beta concentration starts at 24 hours after injection of reserpine and reached the peak at 48 h. CONCLUSION: Reserpine induced behavioral depression partially via brain interleukin-1 beta generation. Reserpine 130-139 interleukin 1 beta Rattus norvegicus 16-25 15000880-6 2004 The increase of IL-1 beta concentration starts at 24 hours after injection of reserpine and reached the peak at 48 h. CONCLUSION: Reserpine induced behavioral depression partially via brain interleukin-1 beta generation. Reserpine 130-139 interleukin 1 beta Rattus norvegicus 190-208 14769784-4 2004 Injection of carrageenan into the pleural cavity of rats elicited an acute inflammatory response characterized by: fluid accumulation in the pleural cavity which contained a large number of polymorphonuclear cells (PMNs) as well as an infiltration of PMNs in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate (NO(x)), tumour necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta). Carrageenan 13-24 interleukin 1 beta Rattus norvegicus 405-422 14769784-4 2004 Injection of carrageenan into the pleural cavity of rats elicited an acute inflammatory response characterized by: fluid accumulation in the pleural cavity which contained a large number of polymorphonuclear cells (PMNs) as well as an infiltration of PMNs in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate (NO(x)), tumour necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta). Carrageenan 13-24 interleukin 1 beta Rattus norvegicus 424-432 15036398-2 2004 The present study determined if aging affects the ability of interleukin-1beta (IL-1beta), a pro-inflammatory cytokine, to induce increased NO production (assessed by Griess reaction) and iNOS mRNA levels (assessed by RT-PCR/agarose gel electrophoresis) in vascular smooth muscle cells (VSMCs) from young (3-month-old) and elderly (20-22-month-old) rats. Sepharose 225-232 interleukin 1 beta Rattus norvegicus 61-78 15036398-2 2004 The present study determined if aging affects the ability of interleukin-1beta (IL-1beta), a pro-inflammatory cytokine, to induce increased NO production (assessed by Griess reaction) and iNOS mRNA levels (assessed by RT-PCR/agarose gel electrophoresis) in vascular smooth muscle cells (VSMCs) from young (3-month-old) and elderly (20-22-month-old) rats. Sepharose 225-232 interleukin 1 beta Rattus norvegicus 80-88 15036398-5 2004 IL-1beta (5 ng/ml) significantly (P < 0.05) increased NO production 3.7-fold in elderly female VSMCs and 6.7-fold in elderly male VSMCs, but had no detectable effect in young female and male VSMCs. vsmcs 98-103 interleukin 1 beta Rattus norvegicus 0-8 15036398-5 2004 IL-1beta (5 ng/ml) significantly (P < 0.05) increased NO production 3.7-fold in elderly female VSMCs and 6.7-fold in elderly male VSMCs, but had no detectable effect in young female and male VSMCs. vsmcs 133-138 interleukin 1 beta Rattus norvegicus 0-8 15036398-5 2004 IL-1beta (5 ng/ml) significantly (P < 0.05) increased NO production 3.7-fold in elderly female VSMCs and 6.7-fold in elderly male VSMCs, but had no detectable effect in young female and male VSMCs. vsmcs 133-138 interleukin 1 beta Rattus norvegicus 0-8 14966365-9 2004 N-Acetylcysteine suppressed the release of TNF-alpha, IL-1 beta, and MG, but enhanced NO production. Acetylcysteine 0-16 interleukin 1 beta Rattus norvegicus 54-63 14755545-0 2004 ERK1/2 and JNKs, but not p38 kinase, are involved in reactive oxygen species-mediated induction of osteopontin gene expression by angiotensin II and interleukin-1beta in adult rat cardiac fibroblasts. Reactive Oxygen Species 53-76 interleukin 1 beta Rattus norvegicus 149-166 14755545-7 2004 Diphenylene iodonium (DPI), inhibitor of NAD(P)H oxidase, and tiron, superoxide scavenger, inhibited Ang II- and Ang II+ IL-1beta-stimulated increases in OPN mRNA. diphenyleneiodonium 0-20 interleukin 1 beta Rattus norvegicus 121-129 14755545-7 2004 Diphenylene iodonium (DPI), inhibitor of NAD(P)H oxidase, and tiron, superoxide scavenger, inhibited Ang II- and Ang II+ IL-1beta-stimulated increases in OPN mRNA. diphenyleneiodonium 22-25 interleukin 1 beta Rattus norvegicus 121-129 15135362-0 2004 Interleukin-1beta up-regulates nitrite production: effects on ovarian function. Nitrites 31-38 interleukin 1 beta Rattus norvegicus 0-17 14755545-7 2004 Diphenylene iodonium (DPI), inhibitor of NAD(P)H oxidase, and tiron, superoxide scavenger, inhibited Ang II- and Ang II+ IL-1beta-stimulated increases in OPN mRNA. 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt 62-67 interleukin 1 beta Rattus norvegicus 121-129 14755545-7 2004 Diphenylene iodonium (DPI), inhibitor of NAD(P)H oxidase, and tiron, superoxide scavenger, inhibited Ang II- and Ang II+ IL-1beta-stimulated increases in OPN mRNA. Superoxides 69-79 interleukin 1 beta Rattus norvegicus 121-129 14755545-12 2004 DPI almost completely inhibited Ang II + IL-1beta-stimulated activation of ERK1/2, while partially inhibiting JNKs. diphenyleneiodonium 0-3 interleukin 1 beta Rattus norvegicus 41-49 14755545-13 2004 PD98059, ERK1/2 pathway inhibitor, and SP600125, JNKs inhibitor, partially inhibited Ang II + IL-1beta-stimulated increases in OPN mRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 interleukin 1 beta Rattus norvegicus 94-102 14755545-13 2004 PD98059, ERK1/2 pathway inhibitor, and SP600125, JNKs inhibitor, partially inhibited Ang II + IL-1beta-stimulated increases in OPN mRNA. pyrazolanthrone 39-47 interleukin 1 beta Rattus norvegicus 94-102 14755545-14 2004 A combination of PD98059 and SP600125 almost completely inhibited Ang II + IL-1beta-stimulated increases in OPN mRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 17-24 interleukin 1 beta Rattus norvegicus 75-83 14755545-14 2004 A combination of PD98059 and SP600125 almost completely inhibited Ang II + IL-1beta-stimulated increases in OPN mRNA. pyrazolanthrone 29-37 interleukin 1 beta Rattus norvegicus 75-83 15082877-10 2004 Capsaicin-induced ablation of sensory neurons significantly delayed ulcer healing and this was accompanied by the significant fall in the GBF and the significant rise in the gastric mucosal gene expression of IL-1beta and TNF-alpha. Capsaicin 0-9 interleukin 1 beta Rattus norvegicus 209-217 15135362-7 2004 Moreover, the selective iNOS inhibitor, 1400 W, completely abolished IL-1beta antisteroidogenic effect, therefore confirming the dependence of IL-1beta action upon iNOS activation. N-((3-(aminomethyl)phenyl)methyl)ethanimidamide 40-46 interleukin 1 beta Rattus norvegicus 69-77 15135362-7 2004 Moreover, the selective iNOS inhibitor, 1400 W, completely abolished IL-1beta antisteroidogenic effect, therefore confirming the dependence of IL-1beta action upon iNOS activation. N-((3-(aminomethyl)phenyl)methyl)ethanimidamide 40-46 interleukin 1 beta Rattus norvegicus 143-151 15123337-7 2004 Sulindac treatment also attenuated an age-related decrease in the NR1 and NR2B NMDA receptor subunits and prevented an age-related increase in the pro-inflammatory cytokine, interleukin 1beta (IL-1beta), in the hippocampus. Sulindac 0-8 interleukin 1 beta Rattus norvegicus 174-191 15123337-7 2004 Sulindac treatment also attenuated an age-related decrease in the NR1 and NR2B NMDA receptor subunits and prevented an age-related increase in the pro-inflammatory cytokine, interleukin 1beta (IL-1beta), in the hippocampus. Sulindac 0-8 interleukin 1 beta Rattus norvegicus 193-201 14972338-5 2004 RESULTS: IL-1beta treatment of untransduced-synoviocyte/chondrocyte co-cultures resulted in markedly decreased proteoglycan synthesis by the chondrocytes, and increased NO and PGE2 levels in the culture medium. Dinoprostone 176-180 interleukin 1 beta Rattus norvegicus 9-17 14972338-6 2004 In contrast, adenovirus-mediated transfer of GFAT in synoviocytes prevented both the decrease in chondrocyte proteoglycan synthesis and increases in NO and PGE2 provoked by IL-1beta. Dinoprostone 156-160 interleukin 1 beta Rattus norvegicus 173-181 15135362-1 2004 We have previously reported that Interleukin-1beta (IL-1beta) affects ovarian function in the rat, modulating prostaglandin and progesterone (P) production. Prostaglandins 110-123 interleukin 1 beta Rattus norvegicus 33-50 15028959-0 2004 The combined inducible nitric oxide synthase inhibitor and free radical scavenger guanidinoethyldisulfide prevents multiple low-dose streptozotocin-induced diabetes in vivo and interleukin-1beta-induced suppression of islet insulin secretion in vitro. bis(2-guanidinoethyl)disulfide 82-105 interleukin 1 beta Rattus norvegicus 177-194 15135362-1 2004 We have previously reported that Interleukin-1beta (IL-1beta) affects ovarian function in the rat, modulating prostaglandin and progesterone (P) production. Prostaglandins 110-123 interleukin 1 beta Rattus norvegicus 52-60 15135362-1 2004 We have previously reported that Interleukin-1beta (IL-1beta) affects ovarian function in the rat, modulating prostaglandin and progesterone (P) production. Progesterone 128-140 interleukin 1 beta Rattus norvegicus 33-50 15135362-1 2004 We have previously reported that Interleukin-1beta (IL-1beta) affects ovarian function in the rat, modulating prostaglandin and progesterone (P) production. Progesterone 128-140 interleukin 1 beta Rattus norvegicus 52-60 15135362-6 2004 L-Arginine (1 and 2 mM) was able to mimic IL-1beta actions and the NOS blocker L-Nitro-Arginin-Methyl Ester reverted these effects. Arginine 0-10 interleukin 1 beta Rattus norvegicus 42-50 14757118-6 2004 Interleukin-1 beta-induced nitrite production was twofold increased by 0.05 microM cerivastatin, and this effect could be reversed by addition of 100 microM mevalonate. Nitrites 27-34 interleukin 1 beta Rattus norvegicus 0-18 14988006-3 2004 In the present work we show that the mono-unsaturates palmitoleate (C16:1) or oleate (C18:1) also cause marked inhibition of apoptosis induced by exposure of clonal BRIN-BD11 beta-cells to serum withdrawal or a combination of interleukin-1beta plus interferon-gamma. mono-unsaturates palmitoleate 37-66 interleukin 1 beta Rattus norvegicus 226-243 14988006-3 2004 In the present work we show that the mono-unsaturates palmitoleate (C16:1) or oleate (C18:1) also cause marked inhibition of apoptosis induced by exposure of clonal BRIN-BD11 beta-cells to serum withdrawal or a combination of interleukin-1beta plus interferon-gamma. Oleic Acid 60-66 interleukin 1 beta Rattus norvegicus 226-243 14973242-5 2004 In cell culture experiments, S1627 inhibited interleukin (IL)-1beta-stimulated nuclear translocation and DNA-binding of NF-kappaB. nitazoxanide 29-34 interleukin 1 beta Rattus norvegicus 45-67 14973242-11 2004 As hypothesized, S1627 prevented the zymosan-induced nuclear translocation of NF-kappaB in the spinal cord and the upregulation of NF-kappaB-responsive genes including cyclooxygenase-2, tumor necrosis factor-alpha, and IL-1beta. nitazoxanide 17-22 interleukin 1 beta Rattus norvegicus 219-227 14973242-11 2004 As hypothesized, S1627 prevented the zymosan-induced nuclear translocation of NF-kappaB in the spinal cord and the upregulation of NF-kappaB-responsive genes including cyclooxygenase-2, tumor necrosis factor-alpha, and IL-1beta. Zymosan 37-44 interleukin 1 beta Rattus norvegicus 219-227 14757118-0 2004 Cerivastatin inhibits proliferation of interleukin-1 beta-induced rat mesangial cells by enhanced formation of nitric oxide. cerivastatin 0-12 interleukin 1 beta Rattus norvegicus 39-57 14757118-6 2004 Interleukin-1 beta-induced nitrite production was twofold increased by 0.05 microM cerivastatin, and this effect could be reversed by addition of 100 microM mevalonate. cerivastatin 83-95 interleukin 1 beta Rattus norvegicus 0-18 14757118-0 2004 Cerivastatin inhibits proliferation of interleukin-1 beta-induced rat mesangial cells by enhanced formation of nitric oxide. Nitric Oxide 111-123 interleukin 1 beta Rattus norvegicus 39-57 14757118-6 2004 Interleukin-1 beta-induced nitrite production was twofold increased by 0.05 microM cerivastatin, and this effect could be reversed by addition of 100 microM mevalonate. Mevalonic Acid 157-167 interleukin 1 beta Rattus norvegicus 0-18 14757118-5 2004 Cerivastatin (0.0625 microM) significantly inhibited DNA synthesis in interleukin-1 beta-stimulated mesangial cells without altering cell viability. cerivastatin 0-12 interleukin 1 beta Rattus norvegicus 70-88 14757118-10 2004 The cyclooxygenase-2 inhibitor celecoxib did not alter DNA synthesis and iNOS or cyclooxygenase-2 expression, but blocked prostacyclin production in interleukin-1 beta and cerivastatin-treated mesangial cells. Celecoxib 31-40 interleukin 1 beta Rattus norvegicus 149-167 14757118-10 2004 The cyclooxygenase-2 inhibitor celecoxib did not alter DNA synthesis and iNOS or cyclooxygenase-2 expression, but blocked prostacyclin production in interleukin-1 beta and cerivastatin-treated mesangial cells. Epoprostenol 122-134 interleukin 1 beta Rattus norvegicus 149-167 14741443-5 2004 Furthermore, THC administration resulted in decreased levels of mRNA for the pro-inflammatory cytokines interleukin-1 alpha, interleukin-1 beta, and tumor necrosis factor alpha for neonatal rat microglia co-cultured with Acanthamoeba. Dronabinol 13-16 interleukin 1 beta Rattus norvegicus 125-143 14758170-10 2004 The results show further increases in serum concentrations of tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 in aminobenzotriazole-treated animals at 10 hrs after CLP, which was associated with elevated concentrations of circulating lactate and severe morphologic alterations in the liver. 1H-1,2,3-benzotriazol-4-amine 131-149 interleukin 1 beta Rattus norvegicus 91-108 14729054-1 2004 Generation of high levels of nitric oxide (NO) following induction of NOS2 by interleukin-1 beta (IL-1beta) triggers beta cell apoptosis in insulin-secreting RINm5F cells. Nitric Oxide 29-41 interleukin 1 beta Rattus norvegicus 78-96 14729054-1 2004 Generation of high levels of nitric oxide (NO) following induction of NOS2 by interleukin-1 beta (IL-1beta) triggers beta cell apoptosis in insulin-secreting RINm5F cells. Nitric Oxide 29-41 interleukin 1 beta Rattus norvegicus 98-106 14729054-3 2004 We report in the present paper that exposure of insulin-producing RINm5F cells to NO donors and to IL-1beta leads to oxidative carbonylation of both Bcl-2 and the adenine nucleotide translocator (ANT) component of the mitochondrial PT pore. Adenine Nucleotides 163-181 interleukin 1 beta Rattus norvegicus 99-107 14684360-6 2004 Only carvedilol suppressed myocardial mRNA expression of inflammatory cytokines and IL-1beta protein expression in myocarditis. Carvedilol 5-15 interleukin 1 beta Rattus norvegicus 84-92 14581482-5 2004 Either PD98059 or U0126, selective inhibitors of MEK, or overexpression of a dominant negative MEK-1 inhibited interleukin-1beta- induced ERK activation and the expression of iNOS and COX-2 but had essentially no effect on the expression of VCAM-1 and Mn-SOD. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 7-14 interleukin 1 beta Rattus norvegicus 111-128 14581482-5 2004 Either PD98059 or U0126, selective inhibitors of MEK, or overexpression of a dominant negative MEK-1 inhibited interleukin-1beta- induced ERK activation and the expression of iNOS and COX-2 but had essentially no effect on the expression of VCAM-1 and Mn-SOD. U 0126 18-23 interleukin 1 beta Rattus norvegicus 111-128 16137000-5 2004 But the contents of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6, and IL-8) in the CTMM group were much lower than those in the scalded group. ctmm 92-96 interleukin 1 beta Rattus norvegicus 59-67 14724246-2 2004 A pharmacological activator of AMPK, 5-amino-4-imidazole carboxamide riboside (AICAR) inhibited lipopolysaccharide (LPS)-induced expression of proinflammatory cytokines (tumor necrosis factor alpha, interleukin-1beta, and interleukin-6) and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages. 5-amino-4-imidazole carboxamide riboside 37-77 interleukin 1 beta Rattus norvegicus 199-216 14724246-2 2004 A pharmacological activator of AMPK, 5-amino-4-imidazole carboxamide riboside (AICAR) inhibited lipopolysaccharide (LPS)-induced expression of proinflammatory cytokines (tumor necrosis factor alpha, interleukin-1beta, and interleukin-6) and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages. acadesine 79-84 interleukin 1 beta Rattus norvegicus 199-216 14698450-4 2004 Lovastatin also tends to reduce, although not in a significant manner, basal and interleukin-1beta-stimulated PGE2 release from astrocytes. Lovastatin 0-10 interleukin 1 beta Rattus norvegicus 81-98 14698450-4 2004 Lovastatin also tends to reduce, although not in a significant manner, basal and interleukin-1beta-stimulated PGE2 release from astrocytes. Dinoprostone 110-114 interleukin 1 beta Rattus norvegicus 81-98 14707577-17 2004 Moreover, serum interleukin-1beta, tumor necrosis factor-alpha, and interleukin-6 were elevated in nonsurvivors compared with survivors after cocaine and lipopolysaccharide administration. Cocaine 142-149 interleukin 1 beta Rattus norvegicus 16-62 15217752-2 2004 We report here that the inhibitor of p38 MAPK (p38), SB203580 (10-100 microM) inhibits interleukin-1beta (IL-1beta)-induced nitric oxide production in rat insulin-producing RINm5F cells. SB 203580 53-61 interleukin 1 beta Rattus norvegicus 87-104 15217752-2 2004 We report here that the inhibitor of p38 MAPK (p38), SB203580 (10-100 microM) inhibits interleukin-1beta (IL-1beta)-induced nitric oxide production in rat insulin-producing RINm5F cells. SB 203580 53-61 interleukin 1 beta Rattus norvegicus 106-114 15217752-2 2004 We report here that the inhibitor of p38 MAPK (p38), SB203580 (10-100 microM) inhibits interleukin-1beta (IL-1beta)-induced nitric oxide production in rat insulin-producing RINm5F cells. Nitric Oxide 124-136 interleukin 1 beta Rattus norvegicus 87-104 15217752-2 2004 We report here that the inhibitor of p38 MAPK (p38), SB203580 (10-100 microM) inhibits interleukin-1beta (IL-1beta)-induced nitric oxide production in rat insulin-producing RINm5F cells. Nitric Oxide 124-136 interleukin 1 beta Rattus norvegicus 106-114 15217752-3 2004 SB203580 also counteracts apoptosis induced by a combination of IL-1beta and interferon-gamma. SB 203580 0-8 interleukin 1 beta Rattus norvegicus 64-72 15791834-0 2004 Effect of interleukin-1beta on the variation of adenylyl cyclase expression in rats with seizures induced by L-glutamate. Glutamic Acid 109-120 interleukin 1 beta Rattus norvegicus 10-27 15165121-4 2004 After silicon tubulization of sciatic nerve in rat, 15 microl 1 ng/ml IL-1beta and PBS solution were injected into the silicon capsule respectively. Silicon 119-126 interleukin 1 beta Rattus norvegicus 70-78 15791834-1 2004 To explore the mechanism of interleukin-1beta (IL-1beta) in the onset of seizure and the effect of IL-1beta on the expression of adenylyl cyclase (AC) in rats with seizure induced by L-glutamate. Glutamic Acid 183-194 interleukin 1 beta Rattus norvegicus 99-107 15791834-10 2004 The results indicated that IL-1beta could facilitate the onset of epilepsy induced by L-glutamate through IL-1R, metabotropic glutamate receptors might work with IL-1R and the increased expression of AC might be involved in the process. Glutamic Acid 86-97 interleukin 1 beta Rattus norvegicus 27-35 15316242-3 2004 Little is known about regulation of their production, and therefore the purpose of the present work was to describe the relationship between circulating corticosterone and the mRNA expression of proopiomelanocortin (POMC), IL-1 beta and IL-6 in the AP during a 24-hour cycle in normal rats and rats with acute adjuvant arthritis (AA). Corticosterone 153-167 interleukin 1 beta Rattus norvegicus 223-232 14732351-2 2004 METHODS AND RESULTS: Treatment of interleukin-1beta-stimulated RA-SMC with aminoguanidine led to an increase of 96% in MMP-9 activity (P = 0.003) by gelatin zymography, a 40% increase in pro-MMP-9 protein (P = 0.018) by Western blot, and a 155% increase in MMP-9 mRNA (P = 0.06) by reverse transcription polymerase chain reaction. pimagedine 75-89 interleukin 1 beta Rattus norvegicus 34-51 15316242-14 2004 CONCLUSION: These results suggest a regulatory relationship between circulating corticosterone and the expression of POMC, IL-1 beta and IL-6 in AP of normal rats. Corticosterone 80-94 interleukin 1 beta Rattus norvegicus 123-132 15316244-0 2004 Somatostatin and gamma-aminobutyric acid inhibit interleukin-1 beta-stimulated release of interleukin-6 from rat C6 glioma cells. gamma-Aminobutyric Acid 17-40 interleukin 1 beta Rattus norvegicus 49-67 15316244-6 2004 GABA also prevented IL-1 beta-driven IL-6 release (ED(50) = 100 microM). gamma-Aminobutyric Acid 0-4 interleukin 1 beta Rattus norvegicus 20-29 15316244-7 2004 IL-1 beta and LPC synergistically enhanced release of IL-6 in the presence of the beta-adrenergic receptor agonist isoproterenol (ISO); these effects were largely reversed by SRIF or GABA. Isoproterenol 115-128 interleukin 1 beta Rattus norvegicus 0-9 15316244-7 2004 IL-1 beta and LPC synergistically enhanced release of IL-6 in the presence of the beta-adrenergic receptor agonist isoproterenol (ISO); these effects were largely reversed by SRIF or GABA. Isoproterenol 130-133 interleukin 1 beta Rattus norvegicus 0-9 15501601-2 2004 Here we have examined whether pretreatment of rats with the proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha causes sensitization of vagal afferent pathways to HCl. Hydrochloric Acid 187-190 interleukin 1 beta Rattus norvegicus 86-135 15316244-7 2004 IL-1 beta and LPC synergistically enhanced release of IL-6 in the presence of the beta-adrenergic receptor agonist isoproterenol (ISO); these effects were largely reversed by SRIF or GABA. gamma-Aminobutyric Acid 183-187 interleukin 1 beta Rattus norvegicus 0-9 15501601-7 2004 administration of interleukin-1beta and tumor necrosis factor-alpha alone induced c-Fos in the brainstem, an effect that was gone after 24 h. At this time, however, the effect of HCl to cause expression of c-Fos in the nucleus tractus solitarii was significantly enhanced by pretreatment with interleukin-1beta and tumor necrosis factor-alpha. Hydrochloric Acid 179-182 interleukin 1 beta Rattus norvegicus 18-67 15501601-7 2004 administration of interleukin-1beta and tumor necrosis factor-alpha alone induced c-Fos in the brainstem, an effect that was gone after 24 h. At this time, however, the effect of HCl to cause expression of c-Fos in the nucleus tractus solitarii was significantly enhanced by pretreatment with interleukin-1beta and tumor necrosis factor-alpha. Hydrochloric Acid 179-182 interleukin 1 beta Rattus norvegicus 293-342 15501601-10 2004 These results show that peripheral administration of the proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha induces prolonged sensitization of vagal afferent pathways to gastric HCl challenge. Hydrochloric Acid 203-206 interleukin 1 beta Rattus norvegicus 83-132 15316244-8 2004 The pyridinylimidazole inhibitor of p38, SB-203580, completely blocked stimulation of IL-6 release by IL-1 beta or LPC; conversely, the anthrapyrazolone JNK inhibitor, SP-600125, was ineffective in modifying stimulated IL-6 release. CHEMBL96741 4-22 interleukin 1 beta Rattus norvegicus 102-111 15316244-8 2004 The pyridinylimidazole inhibitor of p38, SB-203580, completely blocked stimulation of IL-6 release by IL-1 beta or LPC; conversely, the anthrapyrazolone JNK inhibitor, SP-600125, was ineffective in modifying stimulated IL-6 release. SB 203580 41-50 interleukin 1 beta Rattus norvegicus 102-111 15316244-9 2004 CONCLUSIONS: The effects of IL-1 beta and LPC on IL-6 release from glioma cells are effectively antagonized by the inhibitory neurotransmitters SRIF and GABA. gamma-Aminobutyric Acid 153-157 interleukin 1 beta Rattus norvegicus 28-37 14723342-0 2003 Ursodeoxycholic acid inhibits pro-inflammatory repertoires, IL-1 beta and nitric oxide in rat microglia. Ursodeoxycholic Acid 0-20 interleukin 1 beta Rattus norvegicus 60-69 15047987-1 2004 The aim of present study was to evaluate the effects of immunophilin ligands (cyclosporin A, FK506 and rapamycin) on the simulated ischemia-induced release of pro-inflammatory cytokines (IL-1beta, TNF-alpha and IL-2) in rat primary astrocyte cell cultures. Sirolimus 103-112 interleukin 1 beta Rattus norvegicus 187-195 15047987-3 2004 In vitro simulated ischemia significantly increased secretion of IL-1beta, TNF-alpha and IL-2 by astrocyte cultures deprived of microglia (by shaking and incubating with L-leucine methyl ester). leucine methyl ester 170-192 interleukin 1 beta Rattus norvegicus 65-73 15047987-4 2004 CsA (at concentrations of 10-50 microM), FK506 (at all used concentrations) and rapamycin (in dose-dependent manner) significantly attenuated IL-1beta release after 24 h exposure to ischemic conditions. Cyclosporine 0-3 interleukin 1 beta Rattus norvegicus 142-150 15047987-4 2004 CsA (at concentrations of 10-50 microM), FK506 (at all used concentrations) and rapamycin (in dose-dependent manner) significantly attenuated IL-1beta release after 24 h exposure to ischemic conditions. Tacrolimus 41-46 interleukin 1 beta Rattus norvegicus 142-150 15047987-4 2004 CsA (at concentrations of 10-50 microM), FK506 (at all used concentrations) and rapamycin (in dose-dependent manner) significantly attenuated IL-1beta release after 24 h exposure to ischemic conditions. Sirolimus 80-89 interleukin 1 beta Rattus norvegicus 142-150 14625016-0 2003 Central cyclooxygenase-2 participates in interleukin-1 beta-induced hyperalgesia in the orofacial formalin test of freely moving rats. Formaldehyde 98-106 interleukin 1 beta Rattus norvegicus 41-59 14625016-6 2003 Pretreatment with indomethacin, a non-selective COX inhibitor, or NS-398, a selective COX-2 inhibitor, blocked IL-1beta-induced hyperalgesic responses. Indomethacin 18-30 interleukin 1 beta Rattus norvegicus 111-119 14625016-6 2003 Pretreatment with indomethacin, a non-selective COX inhibitor, or NS-398, a selective COX-2 inhibitor, blocked IL-1beta-induced hyperalgesic responses. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 66-72 interleukin 1 beta Rattus norvegicus 111-119 15283957-0 2004 The role of IL-1beta in stress-induced sensitization of proinflammatory cytokine and corticosterone responses. Corticosterone 85-99 interleukin 1 beta Rattus norvegicus 12-20 14728979-3 2004 Because it has been demonstrated that such effects are often associated with inflammation, the effect of uranium on TNFalpha, IL-1beta, and IL-10 synthesis by macrophages was assessed in vitro using the NR8383 cell line. Uranium 105-112 interleukin 1 beta Rattus norvegicus 126-134 14525971-5 2003 A close coupling between ROS accumulation and concentration of the pro-inflammatory cytokine, interleukin-1 beta (IL-1 beta) in hippocampus has been reported, and the evidence suggests that IL-1 beta may be responsible for the enhanced ROS production. Reactive Oxygen Species 25-28 interleukin 1 beta Rattus norvegicus 94-112 14525971-5 2003 A close coupling between ROS accumulation and concentration of the pro-inflammatory cytokine, interleukin-1 beta (IL-1 beta) in hippocampus has been reported, and the evidence suggests that IL-1 beta may be responsible for the enhanced ROS production. Reactive Oxygen Species 25-28 interleukin 1 beta Rattus norvegicus 114-123 14525971-5 2003 A close coupling between ROS accumulation and concentration of the pro-inflammatory cytokine, interleukin-1 beta (IL-1 beta) in hippocampus has been reported, and the evidence suggests that IL-1 beta may be responsible for the enhanced ROS production. Reactive Oxygen Species 25-28 interleukin 1 beta Rattus norvegicus 190-199 14525971-5 2003 A close coupling between ROS accumulation and concentration of the pro-inflammatory cytokine, interleukin-1 beta (IL-1 beta) in hippocampus has been reported, and the evidence suggests that IL-1 beta may be responsible for the enhanced ROS production. Reactive Oxygen Species 236-239 interleukin 1 beta Rattus norvegicus 94-112 14525971-5 2003 A close coupling between ROS accumulation and concentration of the pro-inflammatory cytokine, interleukin-1 beta (IL-1 beta) in hippocampus has been reported, and the evidence suggests that IL-1 beta may be responsible for the enhanced ROS production. Reactive Oxygen Species 236-239 interleukin 1 beta Rattus norvegicus 190-199 14525971-9 2003 Significantly, EPA treatment enhanced hippocampal IL-10 concentration that was inversely correlated with IL-1 beta concentration. Eicosapentaenoic Acid 15-18 interleukin 1 beta Rattus norvegicus 105-114 14512413-3 2003 When ileal smooth muscle strips were cultured with IL-1beta (10 ng/ml), contractions elicited by high K+ and carbachol were inhibited in a time-dependent manner. Carbachol 109-118 interleukin 1 beta Rattus norvegicus 51-59 14512413-4 2003 IL-1beta more strongly inhibited the carbachol-induced contractions than high K+ with decreasing myosin light chain phosphorylation. Carbachol 37-46 interleukin 1 beta Rattus norvegicus 0-8 14512413-5 2003 In the alpha-toxin-permeabilized ileal muscle, carbachol with GTP or guanosine 5"-3-O-(thio)triphosphate increased the Ca2+ sensitivity of contractile elements, and this G protein-coupled Ca2+ sensitization was significantly reduced in the IL-1beta-treated ileum. Carbachol 47-56 interleukin 1 beta Rattus norvegicus 240-248 14512413-5 2003 In the alpha-toxin-permeabilized ileal muscle, carbachol with GTP or guanosine 5"-3-O-(thio)triphosphate increased the Ca2+ sensitivity of contractile elements, and this G protein-coupled Ca2+ sensitization was significantly reduced in the IL-1beta-treated ileum. Guanosine Triphosphate 62-65 interleukin 1 beta Rattus norvegicus 240-248 14512413-5 2003 In the alpha-toxin-permeabilized ileal muscle, carbachol with GTP or guanosine 5"-3-O-(thio)triphosphate increased the Ca2+ sensitivity of contractile elements, and this G protein-coupled Ca2+ sensitization was significantly reduced in the IL-1beta-treated ileum. Guanosine 5'-O-(3-Thiotriphosphate) 69-104 interleukin 1 beta Rattus norvegicus 240-248 14675850-9 2003 Plasma level of IL-1beta was higher and IL-6 was lower in the metoprolol group. Metoprolol 62-72 interleukin 1 beta Rattus norvegicus 16-24 14653967-6 2003 RESULTS: The levels of TNF-alpha, IL-1beta, IL-6, TGF-beta, total and differential WCC in BALF of MC groups were significantly decreased than that of COPD group (P<0.01), and there was no significant difference among MC groups. Methylcholanthrene 98-100 interleukin 1 beta Rattus norvegicus 34-42 14691386-4 2003 RESULTS: Chronic ethanol intake increased both the serum levels of IL-1beta and IL-10 and the expression of IL-1RI, but not of IL-10R, in the liver microsomal fraction. Ethanol 17-24 interleukin 1 beta Rattus norvegicus 67-75 14691386-6 2003 It is interesting to note that ethanol, either given in a single dose or chronically fed, stimulated IL-1beta and IL-10 release from cultured hepatocytes. Ethanol 31-38 interleukin 1 beta Rattus norvegicus 101-109 14691386-7 2003 Stimulation of hepatocytes with IL-1beta caused a higher activation of IL-1-associated kinase, extracellular receptor-activated kinases 1 and 2, and nuclear factor-kappaB (NF-kappaB) in hepatocytes from alcohol-fed animals than from controls. Alcohols 203-210 interleukin 1 beta Rattus norvegicus 32-40 14691386-9 2003 Our results suggest the participation of the extracellular signal-regulated kinase (ERK)1/2 pathway in ethanol-induced NF-kappaB activation, because treatment with PD-98059, an ERK1/2 inhibitor, partially suppressed IL-1beta-induced NF-kappaB expression. Ethanol 103-110 interleukin 1 beta Rattus norvegicus 216-224 14691386-10 2003 CONCLUSIONS: Chronic ethanol intake potentiates the action of the proinflammatory cytokine IL-1beta, enhancing the release and signaling response of IL-1beta in the hepatocyte, which in conjunction with other cytokines or LPS may exacerbate the inflammatory damage associated with alcoholic liver disease. Ethanol 21-28 interleukin 1 beta Rattus norvegicus 91-99 14691386-10 2003 CONCLUSIONS: Chronic ethanol intake potentiates the action of the proinflammatory cytokine IL-1beta, enhancing the release and signaling response of IL-1beta in the hepatocyte, which in conjunction with other cytokines or LPS may exacerbate the inflammatory damage associated with alcoholic liver disease. Ethanol 21-28 interleukin 1 beta Rattus norvegicus 149-157 14996425-8 2003 Immunoblots of extracts of IL-1beta-treated cells cultivated with or without the iNOS inhibitor N(G)-monomethyl-L-arginine and the inhibitor of soluble guanylyl cyclase (sGC) 1H-[1,2,4]oxadiazole[4,3-a]quinoxalin-1-one (ODQ) demonstrated that the upregulation of the Mn-SOD by NO is due to a NO-dependent activation of sGC. 1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one 175-218 interleukin 1 beta Rattus norvegicus 27-35 14629650-4 2003 Cultured rat PASMCs were treated with IL-1beta, TNF-alpha, or MIF. pasmcs 13-19 interleukin 1 beta Rattus norvegicus 38-46 14629650-7 2003 IL-1beta increased PGI2 production in a dose-dependent manner. Epoprostenol 19-23 interleukin 1 beta Rattus norvegicus 0-8 14642796-10 2003 Administration of rofecoxib significantly (P<0.05) reduced the colonic damage, the degree of neutrophil infiltration, and interleukin-1 beta levels. rofecoxib 18-27 interleukin 1 beta Rattus norvegicus 125-143 14723822-9 2003 RESULTS: (1) The WC and Na(+), MDA, TNF-alpha and IL-1beta were increased in PB group compared with NS group (P < 0.01); they were decreased in HS and CUR groups compared with PB group (P < 0.01 or P < 0.05). pladienolide B 77-79 interleukin 1 beta Rattus norvegicus 50-58 14611637-2 2003 In rats, PGF(2alpha) and interleukin 1beta (IL-1beta) are involved in structural luteolysis, PGF(2alpha) by increasing ovarian lipid peroxidation, and IL-1beta by reducing progesterone and increasing PGF(2alpha) concentrations. Prostaglandins F 9-12 interleukin 1 beta Rattus norvegicus 151-159 14563479-9 2003 Depletion of membrane-bound cholesterol using methyl-beta-cyclodextrin, which also disrupts caveolar organization within the plasma membrane, abolished IL-1 beta-induced NO release suggesting that IL-1 beta-mediated Ras-dependent signaling in these cells involves the intermediacy of caveolae and their key constituents (e.g. caveolin-1) in isolated beta cells. Cholesterol 28-39 interleukin 1 beta Rattus norvegicus 152-161 14563479-9 2003 Depletion of membrane-bound cholesterol using methyl-beta-cyclodextrin, which also disrupts caveolar organization within the plasma membrane, abolished IL-1 beta-induced NO release suggesting that IL-1 beta-mediated Ras-dependent signaling in these cells involves the intermediacy of caveolae and their key constituents (e.g. caveolin-1) in isolated beta cells. Cholesterol 28-39 interleukin 1 beta Rattus norvegicus 197-206 14563479-9 2003 Depletion of membrane-bound cholesterol using methyl-beta-cyclodextrin, which also disrupts caveolar organization within the plasma membrane, abolished IL-1 beta-induced NO release suggesting that IL-1 beta-mediated Ras-dependent signaling in these cells involves the intermediacy of caveolae and their key constituents (e.g. caveolin-1) in isolated beta cells. methyl-beta-cyclodextrin 46-70 interleukin 1 beta Rattus norvegicus 152-161 14563479-9 2003 Depletion of membrane-bound cholesterol using methyl-beta-cyclodextrin, which also disrupts caveolar organization within the plasma membrane, abolished IL-1 beta-induced NO release suggesting that IL-1 beta-mediated Ras-dependent signaling in these cells involves the intermediacy of caveolae and their key constituents (e.g. caveolin-1) in isolated beta cells. methyl-beta-cyclodextrin 46-70 interleukin 1 beta Rattus norvegicus 197-206 14596894-6 2003 The control animals received an injection of the vehicle for IL-1beta (0.1% PBS-BSA). Lead 76-79 interleukin 1 beta Rattus norvegicus 61-69 14563479-0 2003 Novel roles for palmitoylation of Ras in IL-1 beta-induced nitric oxide release and caspase 3 activation in insulin-secreting beta cells. Nitric Oxide 59-71 interleukin 1 beta Rattus norvegicus 41-50 14563479-2 2003 Since palmitoylation of Ras has been implicated in its membrane targeting, we examined the contributory roles of palmitoylation of Ras in IL-1 beta-induced nitric oxide (NO) release and subsequent activation of caspases. Nitric Oxide 156-168 interleukin 1 beta Rattus norvegicus 138-147 14563479-3 2003 Preincubation of HIT-T15 or INS-1 cells with cerulenin (CER, 134 microM; 3 hr), an inhibitor of protein palmitoylation, significantly reduced (-95%) IL-1 beta-induced NO release from these cells. Cerulenin 45-54 interleukin 1 beta Rattus norvegicus 149-158 14563479-3 2003 Preincubation of HIT-T15 or INS-1 cells with cerulenin (CER, 134 microM; 3 hr), an inhibitor of protein palmitoylation, significantly reduced (-95%) IL-1 beta-induced NO release from these cells. Cerulenin 56-59 interleukin 1 beta Rattus norvegicus 149-158 14563479-4 2003 2-Bromopalmitate, a structurally distinct inhibitor of protein palmitoylation, but not 2-hydroxymyristic acid, an inhibitor of protein myristoylation, also reduced (-67%) IL-1 beta-induced NO release from HIT cells. 2-bromopalmitate 0-16 interleukin 1 beta Rattus norvegicus 171-180 14686802-4 2003 Incubation with FBR extract resulted in a significant reduction of IL-1beta and IFN-gamma-induced nitric oxide (NO) production, a finding that correlated well with reduced levels of the inducible form of NO synthase (iNOS) mRNA and protein. fbr 16-19 interleukin 1 beta Rattus norvegicus 67-75 14576508-4 2003 Incubation of cultures with interleukin (IL)-1beta (10 ng/mL) caused a significant increase in nitrite production. Nitrites 95-102 interleukin 1 beta Rattus norvegicus 28-50 14576508-5 2003 C-reactive protein significantly decreased the IL-1beta-induced nitrite production by VSMCs in a dose-dependent manner (10-100 microg/mL). Nitrites 64-71 interleukin 1 beta Rattus norvegicus 47-55 14576508-5 2003 C-reactive protein significantly decreased the IL-1beta-induced nitrite production by VSMCs in a dose-dependent manner (10-100 microg/mL). vsmcs 86-91 interleukin 1 beta Rattus norvegicus 47-55 14611637-2 2003 In rats, PGF(2alpha) and interleukin 1beta (IL-1beta) are involved in structural luteolysis, PGF(2alpha) by increasing ovarian lipid peroxidation, and IL-1beta by reducing progesterone and increasing PGF(2alpha) concentrations. Progesterone 172-184 interleukin 1 beta Rattus norvegicus 25-42 14611637-2 2003 In rats, PGF(2alpha) and interleukin 1beta (IL-1beta) are involved in structural luteolysis, PGF(2alpha) by increasing ovarian lipid peroxidation, and IL-1beta by reducing progesterone and increasing PGF(2alpha) concentrations. Progesterone 172-184 interleukin 1 beta Rattus norvegicus 44-52 14611637-2 2003 In rats, PGF(2alpha) and interleukin 1beta (IL-1beta) are involved in structural luteolysis, PGF(2alpha) by increasing ovarian lipid peroxidation, and IL-1beta by reducing progesterone and increasing PGF(2alpha) concentrations. Prostaglandins F 93-96 interleukin 1 beta Rattus norvegicus 25-42 14611637-2 2003 In rats, PGF(2alpha) and interleukin 1beta (IL-1beta) are involved in structural luteolysis, PGF(2alpha) by increasing ovarian lipid peroxidation, and IL-1beta by reducing progesterone and increasing PGF(2alpha) concentrations. Prostaglandins F 93-96 interleukin 1 beta Rattus norvegicus 44-52 14611637-5 2003 At 15 ng ml(-1), IL-1beta inhibited progesterone after 4 and 8 h of culture without affecting PGF(2alpha) production, and a longer incubation (21 h) was needed to increase PGF(2alpha) production. Progesterone 36-48 interleukin 1 beta Rattus norvegicus 17-25 14611637-6 2003 In contrast, IL-1beta enhanced PGF(2alpha) concentrations at 8 h only at the higher dose (25 ng ml(-1)). Prostaglandins F 31-34 interleukin 1 beta Rattus norvegicus 13-21 14611637-7 2003 The observed reduction in progesterone synthesis at the lower dose of IL-1beta before the increase in PGF(2alpha) concentrations led to the hypothesis that IL-1beta regulates functional luteolysis (progesterone diminution) before it affects structural luteolysis (PGF(2alpha) increase). Prostaglandins F 102-105 interleukin 1 beta Rattus norvegicus 156-164 14611637-7 2003 The observed reduction in progesterone synthesis at the lower dose of IL-1beta before the increase in PGF(2alpha) concentrations led to the hypothesis that IL-1beta regulates functional luteolysis (progesterone diminution) before it affects structural luteolysis (PGF(2alpha) increase). Progesterone 26-38 interleukin 1 beta Rattus norvegicus 156-164 14611637-7 2003 The observed reduction in progesterone synthesis at the lower dose of IL-1beta before the increase in PGF(2alpha) concentrations led to the hypothesis that IL-1beta regulates functional luteolysis (progesterone diminution) before it affects structural luteolysis (PGF(2alpha) increase). Prostaglandins F 264-267 interleukin 1 beta Rattus norvegicus 156-164 14611637-2 2003 In rats, PGF(2alpha) and interleukin 1beta (IL-1beta) are involved in structural luteolysis, PGF(2alpha) by increasing ovarian lipid peroxidation, and IL-1beta by reducing progesterone and increasing PGF(2alpha) concentrations. Prostaglandins F 93-96 interleukin 1 beta Rattus norvegicus 25-42 14611637-2 2003 In rats, PGF(2alpha) and interleukin 1beta (IL-1beta) are involved in structural luteolysis, PGF(2alpha) by increasing ovarian lipid peroxidation, and IL-1beta by reducing progesterone and increasing PGF(2alpha) concentrations. Prostaglandins F 93-96 interleukin 1 beta Rattus norvegicus 44-52 14576830-5 2003 Electrophoretic mobility-shift assays demonstrated that NF-kappaB binding activity induced by IL-1beta or LPS was also increased in K-rasAsp12-transfected cells, along with the binding of CREB-1, CREM-1, ATF-1, ATF-2, and Jun D to a cAMP-responsive element (CRE)-like site and the binding of C/EBPbeta to a C/EBP-binding consensus site. Cyclic AMP 233-237 interleukin 1 beta Rattus norvegicus 94-102 14576830-10 2003 These results suggest that an activating mutation of K-ras can markedly enhance the iNOS expression mediated by IL-1beta or LPS, through the activation of promoters on NF-kappaB, C/EBP, and CRE-like sites, and that nitric oxide contributes to the colony formation and tumor growth of K-ras-transformed cells. Nitric Oxide 215-227 interleukin 1 beta Rattus norvegicus 112-120 12960105-2 2003 We have previously shown in vitro that IL-1beta induces nitric oxide (NO) and beta-cell damage. Nitric Oxide 56-68 interleukin 1 beta Rattus norvegicus 39-47 13679239-7 2003 Treatment of the thoracic aortas, isolated from control and Mg-deficient rats before endotoxic challenge, with IL-1beta or TNF-alpha for 6 h in vitro caused hyporeactivity to PE, but its severity did not differ significantly between the two groups. Magnesium 60-62 interleukin 1 beta Rattus norvegicus 111-119 13679239-7 2003 Treatment of the thoracic aortas, isolated from control and Mg-deficient rats before endotoxic challenge, with IL-1beta or TNF-alpha for 6 h in vitro caused hyporeactivity to PE, but its severity did not differ significantly between the two groups. Phenylephrine 175-177 interleukin 1 beta Rattus norvegicus 111-119 13679239-8 2003 These results suggest that high serum IL-1beta and TNF-alpha levels, and increased TNF receptor production in the vascular tissue, contribute to vascular hyporeactivity to PE in endotoxemia, and to its enhancement in Mg-deficient rats, via NO/cGMP signaling. Magnesium 217-219 interleukin 1 beta Rattus norvegicus 38-46 12960105-3 2003 Here, we show that IL-1beta administration in vivo to Wistar rats transiently increases manganese superoxide dismutase activity, whereas inducible NO synthase is not detected, and the levels of nitrate+nitrate do not change. nitrate+nitrate 194-209 interleukin 1 beta Rattus norvegicus 19-27 14622206-7 2003 Herbimycin A and genistein also decreased IL-1beta-induced expression of PPT mRNA-encoding transcripts and the levels of SP-li synthesized in the cells and secreted into the culture medium in a concentration-dependent manner. Genistein 17-26 interleukin 1 beta Rattus norvegicus 42-50 14622206-7 2003 Herbimycin A and genistein also decreased IL-1beta-induced expression of PPT mRNA-encoding transcripts and the levels of SP-li synthesized in the cells and secreted into the culture medium in a concentration-dependent manner. herbimycin 0-12 interleukin 1 beta Rattus norvegicus 42-50 14622206-3 2003 Stimulation of IL-1 receptor by IL-1beta may induce the phosphorylation of tyrosine residues in many effector proteins through the activation of p60c-src kinase. Tyrosine 75-83 interleukin 1 beta Rattus norvegicus 32-40 14622206-9 2003 Whereas, IL-1 receptor antagonist and cycloheximide inhibited IL-1beta-evoked secretion of SP-like immunoreactivity (SP-li), actinomycin D decreased it significantly but did not entirely abolish it. Cycloheximide 38-51 interleukin 1 beta Rattus norvegicus 62-70 14622206-9 2003 Whereas, IL-1 receptor antagonist and cycloheximide inhibited IL-1beta-evoked secretion of SP-like immunoreactivity (SP-li), actinomycin D decreased it significantly but did not entirely abolish it. sp-li 91-96 interleukin 1 beta Rattus norvegicus 62-70 14622206-10 2003 These findings show that phosphorylation of specific protein tyrosine residue(s) following IL-1 receptor activation might play a key role in IL-1beta signalling to modulate PPT gene expression and SP secretion in sensory neurons. Tyrosine 61-69 interleukin 1 beta Rattus norvegicus 141-149 14622208-3 2003 IL-1beta treatment also increased serum corticosterone. Corticosterone 40-54 interleukin 1 beta Rattus norvegicus 0-8 14622208-4 2003 This increase in serum corticosterone was further enhanced in rats given both IL-1beta and footshock. Corticosterone 23-37 interleukin 1 beta Rattus norvegicus 78-86 14622208-5 2003 Furthermore, the glucocorticoid receptor antagonist mifepristone blocked IL-1beta-induced elevation in corticosterone and also attenuated the enhanced conditioned fear memory. Mifepristone 52-64 interleukin 1 beta Rattus norvegicus 73-81 14622208-5 2003 Furthermore, the glucocorticoid receptor antagonist mifepristone blocked IL-1beta-induced elevation in corticosterone and also attenuated the enhanced conditioned fear memory. Corticosterone 103-117 interleukin 1 beta Rattus norvegicus 73-81 14622208-6 2003 Central administration of IL-1beta significantly increased prostaglandin E2 and decreased the anti-inflammatory cytokine IL-10 release from whole blood cultures; therefore this treatment appears to be effective in inducing an inflammatory response in both the periphery and the brain. Dinoprostone 59-75 interleukin 1 beta Rattus norvegicus 26-34 12897060-3 2003 Moreover, rosiglitazone both synergized with IL-1beta to further induce prostaglandin release and affected the expression of phospholipase A2 and COX-2. Prostaglandins 72-85 interleukin 1 beta Rattus norvegicus 45-53 12897065-3 2003 Wogonin inhibited inflammatory activation of cultured brain microglia by diminishing lipopolysaccharide-induced tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta, and nitric oxide (NO) production. wogonin 0-7 interleukin 1 beta Rattus norvegicus 153-170 14625533-10 2003 Chronic Kupffer-cell depletion attenuates peptidoglycan-polysaccharide-induced granulomatous inflammation in the colon, liver, and spleen and reduces the incidence of arthritis, possibly by suppressing the production of interleukin-1beta and nitric oxide. peptidoglycan-polysaccharide 42-70 interleukin 1 beta Rattus norvegicus 220-237 14528517-8 2003 FK506 caused a marked reduction of TNF-a and IL-1beta levels in paw tissue even in short-term (3-day) therapeutic treatment. Tacrolimus 0-5 interleukin 1 beta Rattus norvegicus 45-53 14578583-5 2003 Secondarily, we assessed whether the fever induced by either LPS, IL-1beta, or PGE(2) can be altered by pretreatment with buprenorphine (an opioid receptor antagonist). Buprenorphine 122-135 interleukin 1 beta Rattus norvegicus 66-74 14528517-11 2003 MTX reduced IL-1beta levels only in the 6-day treatment. Methotrexate 0-3 interleukin 1 beta Rattus norvegicus 12-20 14528517-12 2003 CONCLUSION: FK506 is more effective than MTX in reducing elevated levels of inflammatory cytokines TNF-a, IL-1beta, and IL-6 in established stages of AIA. Tacrolimus 12-17 interleukin 1 beta Rattus norvegicus 106-114 12892655-10 2003 Six hours after 5-HTP injection, IL-1beta mRNA increased in the hypothalamus. 5-Hydroxytryptophan 16-21 interleukin 1 beta Rattus norvegicus 33-41 12837849-0 2003 Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in rats. Fatty Acids, Omega-6 26-41 interleukin 1 beta Rattus norvegicus 45-62 12837849-1 2003 The present study demonstrated that an omega (n)-3 fatty acid, ethyl-eicosapentaenoic acid (ethyl-EPA), supplemented diet significantly attenuated the stress/anxiety behavior of rats in the "open field" and elevated plus maze, which was induced by subchronic intracerebroventricular administration of proinflammatory cytokine interleukin (IL)-1beta. omega (n)-3 fatty acid 39-61 interleukin 1 beta Rattus norvegicus 326-348 12837849-1 2003 The present study demonstrated that an omega (n)-3 fatty acid, ethyl-eicosapentaenoic acid (ethyl-EPA), supplemented diet significantly attenuated the stress/anxiety behavior of rats in the "open field" and elevated plus maze, which was induced by subchronic intracerebroventricular administration of proinflammatory cytokine interleukin (IL)-1beta. icosapent 63-90 interleukin 1 beta Rattus norvegicus 326-348 12837849-1 2003 The present study demonstrated that an omega (n)-3 fatty acid, ethyl-eicosapentaenoic acid (ethyl-EPA), supplemented diet significantly attenuated the stress/anxiety behavior of rats in the "open field" and elevated plus maze, which was induced by subchronic intracerebroventricular administration of proinflammatory cytokine interleukin (IL)-1beta. icosapent 92-101 interleukin 1 beta Rattus norvegicus 326-348 12837849-4 2003 Following IL-1beta administration, ethyl-EPA reduced the elevated prostaglandin (PG) E2 secretion and increased the secretion of antiinflammatory cytokine IL-10 from whole blood cells. icosapent 35-44 interleukin 1 beta Rattus norvegicus 10-18 14552679-9 2003 The concentrations of IL-1beta were significantly increased in IBE group compared with NS group at 4 hours, 8 hours. ibe 63-66 interleukin 1 beta Rattus norvegicus 22-30 14552679-11 2003 CONCLUSION: IL-1beta and TNF-alpha are involved in infectious brain edema by IBE. ibe 77-80 interleukin 1 beta Rattus norvegicus 12-20 14507968-0 2003 Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. Calcium 64-71 interleukin 1 beta Rattus norvegicus 0-17 14507968-8 2003 Finally, 0.05 ng/ml IL-1beta increased by approximately 30% neuronal cell death induced by NMDA, and this effect was blocked by both lavendustin A and PP2. N-Methylaspartate 91-95 interleukin 1 beta Rattus norvegicus 20-28 14507968-3 2003 Using primary cultures of rat hippocampal neurons, we investigated whether IL-1beta affects NMDA receptor function(s) by studying (1) NMDA receptor-induced [Ca2+]i increase and (2) NMDA-mediated neurotoxicity. N-Methylaspartate 92-96 interleukin 1 beta Rattus norvegicus 75-83 14507968-4 2003 IL1beta (0.01-0.1 ng/ml) dose-dependently enhances NMDA-induced [Ca2+]i increases with a maximal effect of approximately 45%. N-Methylaspartate 51-55 interleukin 1 beta Rattus norvegicus 0-7 14507968-8 2003 Finally, 0.05 ng/ml IL-1beta increased by approximately 30% neuronal cell death induced by NMDA, and this effect was blocked by both lavendustin A and PP2. lavendustin A 133-146 interleukin 1 beta Rattus norvegicus 20-28 14507968-6 2003 Facilitation of NMDA-induced [Ca2+]i increase by IL-1beta was prevented by both lavendustin (LAV) A (500 nm) and 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2) (1 microm), suggesting an involvement of tyrosine kinases. N-Methylaspartate 16-20 interleukin 1 beta Rattus norvegicus 49-57 14507968-6 2003 Facilitation of NMDA-induced [Ca2+]i increase by IL-1beta was prevented by both lavendustin (LAV) A (500 nm) and 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2) (1 microm), suggesting an involvement of tyrosine kinases. lavendustin A 80-99 interleukin 1 beta Rattus norvegicus 49-57 14507968-6 2003 Facilitation of NMDA-induced [Ca2+]i increase by IL-1beta was prevented by both lavendustin (LAV) A (500 nm) and 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2) (1 microm), suggesting an involvement of tyrosine kinases. AG 1879 113-176 interleukin 1 beta Rattus norvegicus 49-57 14507968-6 2003 Facilitation of NMDA-induced [Ca2+]i increase by IL-1beta was prevented by both lavendustin (LAV) A (500 nm) and 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2) (1 microm), suggesting an involvement of tyrosine kinases. pp2 178-181 interleukin 1 beta Rattus norvegicus 49-57 12956704-12 2003 Serotonin enhances wakefulness and these novel data also suggest that IL-1beta-induced enhancement of NREM sleep could be due in part to the inhibition of DRN serotonergic neurons. Serotonin 0-9 interleukin 1 beta Rattus norvegicus 70-78 13130488-1 2003 OBJECTIVE: FR167653 is a potent inhibitor of p38 mitogen-activated protein kinase (MAPK) and inhibits tumor necrosis factor alpha (TNFalpha) and interleukin-1 beta (IL-1 beta) production in inflammatory cells. FR 167653 11-19 interleukin 1 beta Rattus norvegicus 145-163 13130488-1 2003 OBJECTIVE: FR167653 is a potent inhibitor of p38 mitogen-activated protein kinase (MAPK) and inhibits tumor necrosis factor alpha (TNFalpha) and interleukin-1 beta (IL-1 beta) production in inflammatory cells. FR 167653 11-19 interleukin 1 beta Rattus norvegicus 165-174 12967643-2 2003 We investigated the hypothesis that chronic ethanol exposure induces the expression of TNF-alpha and/or IL-1beta and inhibits proliferation during distraction osteogenesis (DO). Ethanol 44-51 interleukin 1 beta Rattus norvegicus 104-112 12967643-4 2003 In the bone marrow, the expression of both TNF-alpha and IL-1beta mRNA was significantly increased by ethanol (p<0.04 for both). Ethanol 102-109 interleukin 1 beta Rattus norvegicus 57-65 12964126-0 2003 Imidazolineoxyl N-oxide prevents the impairment of vascular contraction caused by interleukin-1beta through several mechanisms. imidazolineoxyl n-oxide 0-23 interleukin 1 beta Rattus norvegicus 82-99 12964126-1 2003 Overnight exposure to interleukin (IL)-1beta caused a dramatic hyporesponsiveness to phenylephrine, increased nitric oxide (NO) and prostacyclin production, and induced cycloxygenase-2 expression in rat aortic rings. Phenylephrine 85-98 interleukin 1 beta Rattus norvegicus 22-44 12964126-1 2003 Overnight exposure to interleukin (IL)-1beta caused a dramatic hyporesponsiveness to phenylephrine, increased nitric oxide (NO) and prostacyclin production, and induced cycloxygenase-2 expression in rat aortic rings. Nitric Oxide 110-122 interleukin 1 beta Rattus norvegicus 22-44 12964126-1 2003 Overnight exposure to interleukin (IL)-1beta caused a dramatic hyporesponsiveness to phenylephrine, increased nitric oxide (NO) and prostacyclin production, and induced cycloxygenase-2 expression in rat aortic rings. Epoprostenol 132-144 interleukin 1 beta Rattus norvegicus 22-44 12964126-4 2003 Activation of charybdotoxin-sensitive K(+) channels was probably due to NO stores formed during the exposition to IL-1beta; 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO), either when added with IL-1beta or in the organ bath, partially restored the contractility of IL-1beta-treated vessels. 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole 191-196 interleukin 1 beta Rattus norvegicus 114-122 14499870-8 2003 PPAR-gamma ligands suppressed myocardial mRNA expression of inflammatory cytokines and the expression of interleukin (IL)-1beta protein in rats with EAM. molibresib 149-152 interleukin 1 beta Rattus norvegicus 105-127 12898012-10 2003 Furthermore, in isolated rat pancreatic islets ONO-1714 prevented IL-1beta-induced inhibition of insulin secretion, this protection being evident in much lower concentrations than with L-NMMA. 7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane 47-55 interleukin 1 beta Rattus norvegicus 66-74 12761362-0 2003 IL-1 beta depresses respiration and anoxic survival via a prostaglandin-dependent pathway in neonatal rats. Prostaglandins 58-71 interleukin 1 beta Rattus norvegicus 0-9 12885581-5 2003 NMDA injections resulted in local activation of microglia and an increase in IL-1beta. N-Methylaspartate 0-4 interleukin 1 beta Rattus norvegicus 77-85 14499442-7 2003 Peri-neural clonidine reduced the increase in tissue content of the proinflammatory cytokines IL-1beta and particularly TNFalpha in sciatic nerve, DRG and spinal cord while increasing concentrations of the anti-inflammatory cytokine TGF-beta1. Clonidine 12-21 interleukin 1 beta Rattus norvegicus 94-102 12949723-8 2003 Further, dietary glycine largely prevented increases in IL-1beta and TNF-alpha in the colon 2 days after TNBS, and TNBS induction of CINC and MIP-2 in the colonic tissue also was abrogated by glycine. Glycine 17-24 interleukin 1 beta Rattus norvegicus 56-64 14575314-6 2003 Furthermore, propranolol attenuated IL-1beta mRNA expression, but had not effect on the other cytokines. Propranolol 13-24 interleukin 1 beta Rattus norvegicus 36-44 12761362-2 2003 We hypothesized that IL-1 beta acts in this capacity by depressing brainstem respiratory neurons via a prostaglandin-dependent pathway. Prostaglandins 103-116 interleukin 1 beta Rattus norvegicus 21-30 12761362-12 2003 These findings suggest that IL-1 beta does not inhibit respiratory neurons directly but may depress breathing and hypoxic defense via a prostaglandin-mediated mechanism. Prostaglandins 136-149 interleukin 1 beta Rattus norvegicus 28-37 12812860-0 2003 Systemic apomorphine alters HPA axis responses to interleukin-1 beta administration but not sound stress. Apomorphine 9-20 interleukin 1 beta Rattus norvegicus 50-68 14680578-6 2003 After treated with genistein, BMD and the serum level of ALP, ACP, osteocalcin increased significantly, while the serum level of IL-1beta and TNF-alpha decreased. Genistein 19-28 interleukin 1 beta Rattus norvegicus 129-137 12900941-5 2003 Exposure to iron particles at a concentration of 90 microg/m(3) resulted in a significant decrease in total antioxidant power along with a significant induction in ferritin expression, GST activity, and IL-1beta levels in lungs compared with lungs of the FA control or of animals exposed to iron particles at 57 microg/m(3). Iron 12-16 interleukin 1 beta Rattus norvegicus 203-211 12851700-4 2003 We found that IFN-gamma, IL-1beta, IL-6 and IL-12 mRNA expression of the tumor tissue were higher in the ONO-4007 treated rats than in phosphate buffer saline (PBS) treated rats. ONO 4007 105-113 interleukin 1 beta Rattus norvegicus 25-33 12957354-0 2003 Enhancement by interleukin-1 beta of gastric carcinogenesis induced by N-methyl-N"-nitro-N-nitrosoguanidine in Wistar rats: a possible mechanism for Helicobacter pylori-associated gastric carcinogenesis. Methylnitronitrosoguanidine 71-107 interleukin 1 beta Rattus norvegicus 15-33 12916707-4 2003 IL-1beta stimulated cellular proliferation and the synthesis of prostaglandin E2 and plasminogen activator activity in the cultured cells in a dose-dependent manner. Dinoprostone 64-80 interleukin 1 beta Rattus norvegicus 0-8 12836161-5 2003 In addition, pretreatment of DRG cells with actinomycin D at 1 microM or cyclohexamide at 10 microM for 30 min inhibited 1 ng/ml IL-1beta-induced CGRP release in DRG neurons of neonatal rats. 4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]piperidine-2,6-dione 73-86 interleukin 1 beta Rattus norvegicus 129-137 12836161-5 2003 In addition, pretreatment of DRG cells with actinomycin D at 1 microM or cyclohexamide at 10 microM for 30 min inhibited 1 ng/ml IL-1beta-induced CGRP release in DRG neurons of neonatal rats. Dactinomycin 44-57 interleukin 1 beta Rattus norvegicus 129-137 12829860-0 2003 Prophylactic but not delayed administration of simvastatin protects against long-lasting cognitive and morphological consequences of neonatal hypoxic-ischemic brain injury, reduces interleukin-1beta and tumor necrosis factor-alpha mRNA induction, and does not affect endothelial nitric oxide synthase expression. Simvastatin 47-58 interleukin 1 beta Rattus norvegicus 181-230 12878045-9 2003 However, the addition of 45 microg/m3 of iron to soot with a combined total mass concentration of 250 microg/m3 demonstrated significant pulmonary ferritin induction, oxidative stress, elevation of IL-1beta, and cytochrome P450s, as well as activation of NFkappaB. Iron 41-45 interleukin 1 beta Rattus norvegicus 198-206 12934647-3 2003 Salicylate inhibited the IL-1beta and TNF-alpha-induced COX-2 expressions, regulated the activation of ERK, IKK and IkappaB degradation, and the subsequent activation of NF-kappaB, in neonatal rat ventricular cardiomyocytes. Salicylates 0-10 interleukin 1 beta Rattus norvegicus 25-33 12871756-4 2003 Pioglitazone reduced the area of gastric ulcers and raised significantly the gastric blood flow at the ulcer margin and downregulated the mRNA for interleukin-1beta, TNF-alpha, cyclooxygenase-2 and iNOS while cyclooxygenase-1 mRNA was not affected. Pioglitazone 0-12 interleukin 1 beta Rattus norvegicus 147-164 12871756-6 2003 We conclude that pioglitazone accelerates the healing of preexisting gastric ulcers due to the hyperemia at ulcer margin and the anti-inflammatory action including suppression of interleukin-1beta, TNF-alpha, cyclooxygenase-2 and iNOS and by an overexpression of HSP70. Pioglitazone 17-29 interleukin 1 beta Rattus norvegicus 179-196 12934647-4 2003 The inhibition of the ERK pathway, with a selective inhibitor, PD098059, blocked the expressions of IL-1beta and TNF-alpha-induced COX-2 and PGE2 release. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 63-71 interleukin 1 beta Rattus norvegicus 100-108 12934647-4 2003 The inhibition of the ERK pathway, with a selective inhibitor, PD098059, blocked the expressions of IL-1beta and TNF-alpha-induced COX-2 and PGE2 release. Dinoprostone 141-145 interleukin 1 beta Rattus norvegicus 100-108 12934647-5 2003 The antioxidant, N-acetyl-cysteine, also reduced the glutathione or catalase- attenuated COX-2 expressions in IL-1beta and TNF-alpha-treated cells. Acetylcysteine 17-34 interleukin 1 beta Rattus norvegicus 110-118 12934647-5 2003 The antioxidant, N-acetyl-cysteine, also reduced the glutathione or catalase- attenuated COX-2 expressions in IL-1beta and TNF-alpha-treated cells. Glutathione 53-64 interleukin 1 beta Rattus norvegicus 110-118 12934647-7 2003 In addition, IL-1beta and TNF-alpha stimulated the release of reactive oxygen species (ROS) in the cardiomyocytes. Reactive Oxygen Species 62-85 interleukin 1 beta Rattus norvegicus 13-21 12934647-7 2003 In addition, IL-1beta and TNF-alpha stimulated the release of reactive oxygen species (ROS) in the cardiomyocytes. Reactive Oxygen Species 87-90 interleukin 1 beta Rattus norvegicus 13-21 12810357-6 2003 Treatment with DAA also inhibited the production of macrophage cytokines interleukin-1beta, IL-6 and tumor necrosis factor alpha in response to in vitro stimulation of lymph node and macrophage cells with CII. daa 15-18 interleukin 1 beta Rattus norvegicus 73-90 12871832-15 2003 In conclusion, our results suggest that the TNFalpha-, IL-1beta- and CINC-1-driven release of prostaglandins, sympathetic amines and LTB(4) mediates the first 3 h of mechanical hypersensitivity induced by antigen challenge in rats. Prostaglandins 94-108 interleukin 1 beta Rattus norvegicus 55-63 12871832-15 2003 In conclusion, our results suggest that the TNFalpha-, IL-1beta- and CINC-1-driven release of prostaglandins, sympathetic amines and LTB(4) mediates the first 3 h of mechanical hypersensitivity induced by antigen challenge in rats. sympathetic amines 110-128 interleukin 1 beta Rattus norvegicus 55-63 12871832-15 2003 In conclusion, our results suggest that the TNFalpha-, IL-1beta- and CINC-1-driven release of prostaglandins, sympathetic amines and LTB(4) mediates the first 3 h of mechanical hypersensitivity induced by antigen challenge in rats. Leukotriene B4 133-136 interleukin 1 beta Rattus norvegicus 55-63 12871833-8 2003 Treatment with paeonol dose-dependently inhibited tumour necrosis factor-alpha (TNF-alpha) and interleukin-lbeta (IL-1beta) formation, but enhanced IL-10 production in the rat paw exudates both at the early (1.5 h) and late phase (4 h) after carrageenan injection. paeonol 15-22 interleukin 1 beta Rattus norvegicus 114-122 12839866-20 2003 FK506 reduced IL-1beta and COX-2 mRNA expression and PGE(2) level in arthritic paws. Tacrolimus 0-5 interleukin 1 beta Rattus norvegicus 14-22 12810357-6 2003 Treatment with DAA also inhibited the production of macrophage cytokines interleukin-1beta, IL-6 and tumor necrosis factor alpha in response to in vitro stimulation of lymph node and macrophage cells with CII. N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide 205-208 interleukin 1 beta Rattus norvegicus 73-90 15070082-8 2003 Importantly, both early and late components of reserpine-induced depression and IL-1beta induced depression are reversed by a systemic injection of the highly selective A2A adenosine receptor antagonist 8-(3-Chlorostyryl) caffeine. 8-(3-chlorostyryl)caffeine 203-230 interleukin 1 beta Rattus norvegicus 80-88 12844341-7 2003 Pretreatment of LPS-treated animals by pentoxifylline abolished the LPS-induced rise in serum TNF-alpha (-98% at 90 min; P<0.001 vs LPS alone) and to a lesser extent in serum IL-1beta (-44% at 3 h; not significant vs LPS alone). Pentoxifylline 39-53 interleukin 1 beta Rattus norvegicus 178-186 12817292-4 2003 Protein kinase C (PKC) inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7) prevented LPS-, TNF-alpha- and IL-1beta-induced NO production, whereas N-(2-guanidinoethyl)-5-isoquinoline-sulfonamide (HA1004), an H7 analogue with little activity towards PKC, had no inhibition effect. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 33-78 interleukin 1 beta Rattus norvegicus 115-123 12813363-10 2003 Administration of PAF-AH significantly inhibited LPS-induced tumor necrosis factor alpha and interleukin-1beta production by alveolar macrophages from zymosan-treated animals. Zymosan 151-158 interleukin 1 beta Rattus norvegicus 93-110 12817292-2 2003 Treatment of vascular media and VSMCs with lipopolysaccharide (LPS) or cytokines [tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta)] resulted in a dose-dependent increase of NO release. vsmcs 32-37 interleukin 1 beta Rattus norvegicus 126-144 12782338-4 2003 In the presence of nicotine the inhibitory effect of interleukin-1 beta, interleukin-18 and tumour necrosis factor-alpha on LTP was eliminated. Nicotine 19-27 interleukin 1 beta Rattus norvegicus 53-71 12817292-2 2003 Treatment of vascular media and VSMCs with lipopolysaccharide (LPS) or cytokines [tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta)] resulted in a dose-dependent increase of NO release. vsmcs 32-37 interleukin 1 beta Rattus norvegicus 146-154 12817292-6 2003 Treatment of VSMCs with protein tyrosine kinase (PTK) inhibitor genistein or tyrphostin AG18 also reduced the NO production evoked by LPS, TNF-alpha or IL-1beta, which was associated with inhibition of iNOS protein expression. Genistein 64-73 interleukin 1 beta Rattus norvegicus 152-160 12817292-6 2003 Treatment of VSMCs with protein tyrosine kinase (PTK) inhibitor genistein or tyrphostin AG18 also reduced the NO production evoked by LPS, TNF-alpha or IL-1beta, which was associated with inhibition of iNOS protein expression. tyrphostin A23 77-92 interleukin 1 beta Rattus norvegicus 152-160 14563014-3 2003 Pancreatic islets exposed for 24 h to IL-1beta at a glucose concentration of 6.0 mmol/l exhibited a reduced insulin secretion following a 48h recovery period compared to islets which were cytokine treated at 2.2 or 3.2mmol/l glucose, respectively. Glucose 52-59 interleukin 1 beta Rattus norvegicus 38-46 14563014-3 2003 Pancreatic islets exposed for 24 h to IL-1beta at a glucose concentration of 6.0 mmol/l exhibited a reduced insulin secretion following a 48h recovery period compared to islets which were cytokine treated at 2.2 or 3.2mmol/l glucose, respectively. Glucose 225-232 interleukin 1 beta Rattus norvegicus 38-46 12808286-12 2003 In vivo, after treated with genistein, BMD and the serum level of ALP, ACP, osteocalcin increased significantly, while the serum level of IL-1beta and TNFalpha decreased. Genistein 28-37 interleukin 1 beta Rattus norvegicus 138-146 14563014-5 2003 A temporary (3 h) influence of IL-1beta under hyperglycemic conditions at 11 mmol/l glucose caused a reduction of the subsequent insulin secretion of Langerhans" islets prior incubated for 24 h at 6.0 mmol/l glucose without cytokines, but not of islets precultured at 2.2 mmol/l glucose. Glucose 84-91 interleukin 1 beta Rattus norvegicus 31-39 14563014-5 2003 A temporary (3 h) influence of IL-1beta under hyperglycemic conditions at 11 mmol/l glucose caused a reduction of the subsequent insulin secretion of Langerhans" islets prior incubated for 24 h at 6.0 mmol/l glucose without cytokines, but not of islets precultured at 2.2 mmol/l glucose. Glucose 208-215 interleukin 1 beta Rattus norvegicus 31-39 14563014-5 2003 A temporary (3 h) influence of IL-1beta under hyperglycemic conditions at 11 mmol/l glucose caused a reduction of the subsequent insulin secretion of Langerhans" islets prior incubated for 24 h at 6.0 mmol/l glucose without cytokines, but not of islets precultured at 2.2 mmol/l glucose. Glucose 208-215 interleukin 1 beta Rattus norvegicus 31-39 14563014-9 2003 During glucose stimulation at 11 mmol/l islets" insulin secretory machinery is protected from IL-1beta as well as TNF-alpha plus IFN-gamma for 3 h by a preceding 24 h hypoglycemia, but its vulnerability is restored within additional 3 h. Glucose 7-14 interleukin 1 beta Rattus norvegicus 94-102 12808275-6 2003 Myocardial interleukin-1beta (IL-1beta) expression and IL-1beta-positive cells were significantly less in rats with EAM that were treated with low-dose benidipine compared with untreated rats. benidipine 152-162 interleukin 1 beta Rattus norvegicus 11-28 12808275-6 2003 Myocardial interleukin-1beta (IL-1beta) expression and IL-1beta-positive cells were significantly less in rats with EAM that were treated with low-dose benidipine compared with untreated rats. benidipine 152-162 interleukin 1 beta Rattus norvegicus 30-38 12808275-6 2003 Myocardial interleukin-1beta (IL-1beta) expression and IL-1beta-positive cells were significantly less in rats with EAM that were treated with low-dose benidipine compared with untreated rats. benidipine 152-162 interleukin 1 beta Rattus norvegicus 55-63 12757853-6 2003 LPS-induced plasma levels of IL-6, IL-1beta, and TNF-alpha were also significantly higher in iron-preloaded rats as shown by ELISA, but IFN-gamma levels were unchanged. Iron 93-97 interleukin 1 beta Rattus norvegicus 35-43 12757853-7 2003 We conclude that colloidal-iron phagocytosed by liver Kupffer cells enhanced LPS-induced NO production in vivo, iNOS induction in the liver, and release of IL-6, IL-1beta, and TNF-alpha. Iron 27-31 interleukin 1 beta Rattus norvegicus 162-170 12892381-4 2003 The enhanced release of IL-1beta was completely suppressed by pretreatment with verapamil (a calcium entry blocker), U73122 (a phospholipase C inhibitor), W-7 (a calmodulin inhibitor), and curcumin (an activator-protein [AP]-1 inhibitor), and weakly suppressed by dexamethasone (which inhibits nuclear factor [NF]-kappaB and AP-1). Verapamil 80-89 interleukin 1 beta Rattus norvegicus 24-32 12734649-10 2003 There was a significant higher expression of HSP70 and IL-1beta mRNA in the lungs of the ZEEP group than in the PEEP group and nonventilated controls. zeep 89-93 interleukin 1 beta Rattus norvegicus 55-63 12886986-5 2003 METHODS: To test this hypothesis, indomethacin (IND)-treated peripheral blood mononuclear cell (PBL) cultures from healthy volunteers were stimulated with pokeweed mitogen (PWM), and the cultures were manipulated by adding PGE2, rIFN-gamma, rIL-Ialpha, rIL-1beta, rIL-6, or rIL-12. Indomethacin 34-46 interleukin 1 beta Rattus norvegicus 253-262 12892381-6 2003 From these results, we conclude that the enhanced release of IL-1beta and TNF-alpha from LPS-stimulated alveolar macrophages in low-Mg(2+) medium depends partly on the enhanced synthesis of both cytokines, and occurs partly via identical, and partly via different, signaling pathways. magnesium ion 132-138 interleukin 1 beta Rattus norvegicus 61-69 12892381-4 2003 The enhanced release of IL-1beta was completely suppressed by pretreatment with verapamil (a calcium entry blocker), U73122 (a phospholipase C inhibitor), W-7 (a calmodulin inhibitor), and curcumin (an activator-protein [AP]-1 inhibitor), and weakly suppressed by dexamethasone (which inhibits nuclear factor [NF]-kappaB and AP-1). 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 117-123 interleukin 1 beta Rattus norvegicus 24-32 12892381-4 2003 The enhanced release of IL-1beta was completely suppressed by pretreatment with verapamil (a calcium entry blocker), U73122 (a phospholipase C inhibitor), W-7 (a calmodulin inhibitor), and curcumin (an activator-protein [AP]-1 inhibitor), and weakly suppressed by dexamethasone (which inhibits nuclear factor [NF]-kappaB and AP-1). W 7 155-158 interleukin 1 beta Rattus norvegicus 24-32 12892381-4 2003 The enhanced release of IL-1beta was completely suppressed by pretreatment with verapamil (a calcium entry blocker), U73122 (a phospholipase C inhibitor), W-7 (a calmodulin inhibitor), and curcumin (an activator-protein [AP]-1 inhibitor), and weakly suppressed by dexamethasone (which inhibits nuclear factor [NF]-kappaB and AP-1). Curcumin 189-197 interleukin 1 beta Rattus norvegicus 24-32 12892381-4 2003 The enhanced release of IL-1beta was completely suppressed by pretreatment with verapamil (a calcium entry blocker), U73122 (a phospholipase C inhibitor), W-7 (a calmodulin inhibitor), and curcumin (an activator-protein [AP]-1 inhibitor), and weakly suppressed by dexamethasone (which inhibits nuclear factor [NF]-kappaB and AP-1). Dexamethasone 264-277 interleukin 1 beta Rattus norvegicus 24-32 12609991-6 2003 We suggest that one consequence of these LPS and IL-1 beta-induced changes is a compromise in glutamate release in dentate gyrus, which was coupled with the inhibition of LTP. Glutamic Acid 94-103 interleukin 1 beta Rattus norvegicus 49-58 12738033-5 2003 xanthoides extract completely protected interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma)-mediated cytotoxicity in rat insulinoma cell line (RINm5F). xanthoides 0-10 interleukin 1 beta Rattus norvegicus 40-57 12738033-5 2003 xanthoides extract completely protected interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma)-mediated cytotoxicity in rat insulinoma cell line (RINm5F). xanthoides 0-10 interleukin 1 beta Rattus norvegicus 59-67 12738033-7 2003 xanthoides extract resulted in a significant reduction in IL-1beta and IFN-gamma-induced nitric oxide (NO) production, a finding that correlated well with reduced levels of the inducible form of NO synthase (iNOS) mRNA and protein. xanthoides 0-10 interleukin 1 beta Rattus norvegicus 58-66 12948843-5 2003 On day 3, TNBS-treated animals were killed and the severity of gut inflammation was evaluated by measuring myeloperoxidase (MPO) activity, interleukin-1beta (IL-1beta) production and by scoring macroscopic and histologic colonic damage. Trinitrobenzenesulfonic Acid 10-14 interleukin 1 beta Rattus norvegicus 139-156 12948843-5 2003 On day 3, TNBS-treated animals were killed and the severity of gut inflammation was evaluated by measuring myeloperoxidase (MPO) activity, interleukin-1beta (IL-1beta) production and by scoring macroscopic and histologic colonic damage. Trinitrobenzenesulfonic Acid 10-14 interleukin 1 beta Rattus norvegicus 158-166 12948843-7 2003 In the TNBS group, PG-SPI and PG-KII increased scores for the severity of colonic damage, stimulated the production of IL-1beta and increased granulocyte infiltration into the colon (MPO activity). Trinitrobenzenesulfonic Acid 7-11 interleukin 1 beta Rattus norvegicus 119-127 12948843-7 2003 In the TNBS group, PG-SPI and PG-KII increased scores for the severity of colonic damage, stimulated the production of IL-1beta and increased granulocyte infiltration into the colon (MPO activity). pyroglutamyl-prolyl-asparaginyl-prolyl-aspartyl-glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methioninamide 19-25 interleukin 1 beta Rattus norvegicus 119-127 12948843-7 2003 In the TNBS group, PG-SPI and PG-KII increased scores for the severity of colonic damage, stimulated the production of IL-1beta and increased granulocyte infiltration into the colon (MPO activity). CHEMBL2347657 30-36 interleukin 1 beta Rattus norvegicus 119-127 12803978-11 2003 In cultured rat mesangial cells, DHEF (and DHEA) potently inhibited interleukin-1beta-induced cyclooxygenase-2 (COX2) mRNA and prostaglandin (PGE2) production. dhef 33-37 interleukin 1 beta Rattus norvegicus 68-85 12531724-1 2003 We tested the hypothesis that intracerebroventricular (lateral ventricle) administration of interleukin-1beta (IL-1beta) antibody increases the level of sympathetic nerve discharge (SND) in alpha-chloralose-anesthetized rats. Chloralose 190-206 interleukin 1 beta Rattus norvegicus 92-109 12531724-1 2003 We tested the hypothesis that intracerebroventricular (lateral ventricle) administration of interleukin-1beta (IL-1beta) antibody increases the level of sympathetic nerve discharge (SND) in alpha-chloralose-anesthetized rats. Chloralose 190-206 interleukin 1 beta Rattus norvegicus 111-119 12706339-9 2003 LPS-induced tumor necrosis factor alpha and interleukin-1beta release were lower in taurine-fed rats; however, downregulation of Mrp2 and Bsep expression by LPS was delayed but not prevented. Taurine 84-91 interleukin 1 beta Rattus norvegicus 44-61 12694391-0 2003 Intranigral infusion of interleukin-1beta activates astrocytes and protects from subsequent 6-hydroxydopamine neurotoxicity. Oxidopamine 92-109 interleukin 1 beta Rattus norvegicus 24-41 12694391-6 2003 Intranigral infusion of interleukin-1beta 5 days before a striatal injection of 6-hydroxydopamine significantly protected nigral dopaminergic cell bodies, but not striatal terminals from the 6-hydroxydopamine lesion. Oxidopamine 80-97 interleukin 1 beta Rattus norvegicus 24-41 12694391-6 2003 Intranigral infusion of interleukin-1beta 5 days before a striatal injection of 6-hydroxydopamine significantly protected nigral dopaminergic cell bodies, but not striatal terminals from the 6-hydroxydopamine lesion. Oxidopamine 191-208 interleukin 1 beta Rattus norvegicus 24-41 12694391-7 2003 Also, in the animals pre-treated with interleukin-1beta, a significant prevention of 6-hydroxydopamine-induced reduction of adjusting steps, but not of 6-hydroxydopamine-induced amphetamine rotations, were observed. Oxidopamine 85-102 interleukin 1 beta Rattus norvegicus 38-55 12694391-7 2003 Also, in the animals pre-treated with interleukin-1beta, a significant prevention of 6-hydroxydopamine-induced reduction of adjusting steps, but not of 6-hydroxydopamine-induced amphetamine rotations, were observed. Oxidopamine 152-169 interleukin 1 beta Rattus norvegicus 38-55 12694391-7 2003 Also, in the animals pre-treated with interleukin-1beta, a significant prevention of 6-hydroxydopamine-induced reduction of adjusting steps, but not of 6-hydroxydopamine-induced amphetamine rotations, were observed. Amphetamine 178-189 interleukin 1 beta Rattus norvegicus 38-55 12784914-11 2003 Interleukin-1beta increased to 2 folds on day 21 and 10 folds on day 35 which were significantly brought down by curcumin and ibuprofen. Curcumin 113-121 interleukin 1 beta Rattus norvegicus 0-17 12784914-11 2003 Interleukin-1beta increased to 2 folds on day 21 and 10 folds on day 35 which were significantly brought down by curcumin and ibuprofen. Ibuprofen 126-135 interleukin 1 beta Rattus norvegicus 0-17 12787803-1 2003 In the present study, the effect of FR167653, a novel suppressive agent against interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), on liver regeneration was investigated in rats after partial hepatectomy (PH). FR 167653 36-44 interleukin 1 beta Rattus norvegicus 80-97 12787803-1 2003 In the present study, the effect of FR167653, a novel suppressive agent against interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), on liver regeneration was investigated in rats after partial hepatectomy (PH). FR 167653 36-44 interleukin 1 beta Rattus norvegicus 99-107 12803978-11 2003 In cultured rat mesangial cells, DHEF (and DHEA) potently inhibited interleukin-1beta-induced cyclooxygenase-2 (COX2) mRNA and prostaglandin (PGE2) production. Dehydroepiandrosterone 43-47 interleukin 1 beta Rattus norvegicus 68-85 12803978-11 2003 In cultured rat mesangial cells, DHEF (and DHEA) potently inhibited interleukin-1beta-induced cyclooxygenase-2 (COX2) mRNA and prostaglandin (PGE2) production. Prostaglandins 127-140 interleukin 1 beta Rattus norvegicus 68-85 12803978-11 2003 In cultured rat mesangial cells, DHEF (and DHEA) potently inhibited interleukin-1beta-induced cyclooxygenase-2 (COX2) mRNA and prostaglandin (PGE2) production. Dinoprostone 142-146 interleukin 1 beta Rattus norvegicus 68-85 12682744-9 2003 Omega-3 fatty acids are therefore considered to have an immunosuppressive effect on rat allogenic small intestinal transplantation based on the recipient plasma IL-1 beta, TNF and IL-2 levels and the histological findings of the grafts. Fatty Acids, Omega-3 0-19 interleukin 1 beta Rattus norvegicus 161-170 12743417-7 2003 Indeed, analysis of DNA fragmentation in BRIN-BD11 cells revealed that efaroxan enhanced the level of damage caused by interleukin-1beta. efaroxan 71-79 interleukin 1 beta Rattus norvegicus 119-136 12743417-12 2003 However, since efaroxan enhanced the cytotoxic effects of interleukin-1beta, it appears that this imidazoline may sensitise BRIN-BD11 cells to the damaging effects of certain cytokines. efaroxan 15-23 interleukin 1 beta Rattus norvegicus 58-75 12743417-12 2003 However, since efaroxan enhanced the cytotoxic effects of interleukin-1beta, it appears that this imidazoline may sensitise BRIN-BD11 cells to the damaging effects of certain cytokines. Imidazolines 98-109 interleukin 1 beta Rattus norvegicus 58-75 12689607-1 2003 Administration of bacterial endotoxin (lipopolysachharide; LPS) elevates proinflammatory cytokines, such as interleukin-1beta (IL-1beta) and IL-6, and activates the hypothalamic-pituitary-adrenal (HPA) axis. lipopolysachharide 39-57 interleukin 1 beta Rattus norvegicus 108-125 12689607-1 2003 Administration of bacterial endotoxin (lipopolysachharide; LPS) elevates proinflammatory cytokines, such as interleukin-1beta (IL-1beta) and IL-6, and activates the hypothalamic-pituitary-adrenal (HPA) axis. lipopolysachharide 39-57 interleukin 1 beta Rattus norvegicus 127-135 12761298-0 2003 Nitric oxide synthase induction, cGMP elevation, and biopterin synthesis in vascular smooth muscle cells stimulated with interleukin-1beta in hypoxia. nitric 0-6 interleukin 1 beta Rattus norvegicus 121-138 12744493-7 2003 SB203580 inhibited the activation of p38 MAP kinase, reduced the levels of TNF-alpha and IL-1beta, and prevented burn-mediated lung injury. SB 203580 0-8 interleukin 1 beta Rattus norvegicus 89-97 15139133-7 2003 RESULTS: Both Tangfukang and aminoguanidine significantly decreased the expression of AGEs, but Tangfukang was greatly superior to aminoguanidine in suppressing the expression of cytokine like ICAM-1, IL-1 beta, TNF-alpha and the ingredients of extracellular matrix like IV-C, FN. pimagedine 131-145 interleukin 1 beta Rattus norvegicus 201-210 12711629-3 2003 This study examined the effect of two cytokines, tumour necrosis factor-alpha (TNF) and interleukin-1beta (IL-1) on endothelium-dependent relaxation in response to acetylcholine (ACH), bradykinin (BK) and histamine (HIS) in rat mesenteric small arteries in vitro. Acetylcholine 164-177 interleukin 1 beta Rattus norvegicus 88-105 12675855-8 2003 Treatment with eplerenone reduced systemic osteopontin (58.3 +/- 4.2 ng/mL), albuminuria (41.5 +/- 7.2 mg/24 hours), and proinflammatory gene expression: osteopontin (OPN), monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta). Eplerenone 15-25 interleukin 1 beta Rattus norvegicus 243-260 12675855-8 2003 Treatment with eplerenone reduced systemic osteopontin (58.3 +/- 4.2 ng/mL), albuminuria (41.5 +/- 7.2 mg/24 hours), and proinflammatory gene expression: osteopontin (OPN), monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta). Eplerenone 15-25 interleukin 1 beta Rattus norvegicus 262-270 12754418-3 2003 EGCG effectively protected IL-1beta and IFN-gamma-mediated cytotoxicity in insulinoma cell line (RINm5F). epigallocatechin gallate 0-4 interleukin 1 beta Rattus norvegicus 27-35 12754418-4 2003 EGCG induced a significant reduction in IL-1beta and IFN-gamma-induced nitric oxide (NO) production and reduced levels of the inducible form of NO synthase (iNOS) mRNA and protein levels on RINm5F cells. epigallocatechin gallate 0-4 interleukin 1 beta Rattus norvegicus 40-48 12649265-4 2003 Interleukin-1beta induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and stimulated RNA polymerase II binding to the COX-2 promoter, COX-2 transcription, COX-2 protein synthesis, and prostaglandin E2 (PGE2) release. Dinoprostone 208-224 interleukin 1 beta Rattus norvegicus 0-17 12649265-4 2003 Interleukin-1beta induced the phosphorylation of p38alpha and p38beta2 MAPK in cardiomyocytes and stimulated RNA polymerase II binding to the COX-2 promoter, COX-2 transcription, COX-2 protein synthesis, and prostaglandin E2 (PGE2) release. Dinoprostone 226-230 interleukin 1 beta Rattus norvegicus 0-17 12649265-5 2003 Infecting cardiomyocytes with adenoviruses that encode mutant, phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited interleukin-1beta-induced p38 MAPK activation, COX-2 gene expression, and PGE2 release. Dinoprostone 195-199 interleukin 1 beta Rattus norvegicus 121-138 12649265-6 2003 Treatment with the p38alpha and p38beta2 MAPK inhibitor, SB202190, attenuated interleukin-1beta-induced COX-2 transcription and accelerated the degradation of COX-2 mRNA. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 57-65 interleukin 1 beta Rattus norvegicus 78-95 12649265-9 2003 These results provide direct evidence that MKK6 mediated p38 MAPK activation is necessary for interleukin-1beta-induced cardiac myocyte COX-2 gene expression and PGE2 biosynthesis in vitro and is sufficient for COX-2 gene expression by cardiac myocytes in vitro and in vivo. Dinoprostone 162-166 interleukin 1 beta Rattus norvegicus 94-111 12761298-0 2003 Nitric oxide synthase induction, cGMP elevation, and biopterin synthesis in vascular smooth muscle cells stimulated with interleukin-1beta in hypoxia. Cyclic GMP 33-37 interleukin 1 beta Rattus norvegicus 121-138 12761298-0 2003 Nitric oxide synthase induction, cGMP elevation, and biopterin synthesis in vascular smooth muscle cells stimulated with interleukin-1beta in hypoxia. Biopterin 53-62 interleukin 1 beta Rattus norvegicus 121-138 12761298-1 2003 In cultured rat vascular smooth muscle cells (VSMC), inducible nitric oxide synthase (iNOS) expression evoked by interleukin-1beta (IL-1beta) or tumor necrosis factor-alpha was greatly enhanced in hypoxia (2% O(2)), compared to in normoxia. vsmc 46-50 interleukin 1 beta Rattus norvegicus 113-130 12761298-1 2003 In cultured rat vascular smooth muscle cells (VSMC), inducible nitric oxide synthase (iNOS) expression evoked by interleukin-1beta (IL-1beta) or tumor necrosis factor-alpha was greatly enhanced in hypoxia (2% O(2)), compared to in normoxia. vsmc 46-50 interleukin 1 beta Rattus norvegicus 132-140 12761298-6 2003 In addition, cGMP increased in response to IL-1beta in hypoxia to a level comparable to that in normoxia. Cyclic GMP 13-17 interleukin 1 beta Rattus norvegicus 43-51 12761298-7 2003 Thus, it seems that the IL-1beta-induced expression of iNOS is up-regulated in hypoxia to compensate for a decrease in the enzyme activity due to the lower availability of O(2) as a substrate, and consequently a sufficient amount of NO is produced to elevate cGMP to an adequate level. o(2) 172-176 interleukin 1 beta Rattus norvegicus 24-32 12761298-7 2003 Thus, it seems that the IL-1beta-induced expression of iNOS is up-regulated in hypoxia to compensate for a decrease in the enzyme activity due to the lower availability of O(2) as a substrate, and consequently a sufficient amount of NO is produced to elevate cGMP to an adequate level. Cyclic GMP 259-263 interleukin 1 beta Rattus norvegicus 24-32 12761298-8 2003 In addition, the IL-1beta-induced synthesis of tetrahydrobiopterin, a cofactor for iNOS, was also greatly stimulated by hypoxia in VSMC. sapropterin 47-66 interleukin 1 beta Rattus norvegicus 17-25 12761298-8 2003 In addition, the IL-1beta-induced synthesis of tetrahydrobiopterin, a cofactor for iNOS, was also greatly stimulated by hypoxia in VSMC. vsmc 131-135 interleukin 1 beta Rattus norvegicus 17-25 12841341-12 2003 Our results suggest that FR167653 suppresses the development of myocarditis by suppression of IL-1beta. FR 167653 25-33 interleukin 1 beta Rattus norvegicus 94-102 12753420-2 2003 Ambroxol and erdosteine significantly decreased the production of tumour necrosis factors-alpha, interleukin-1beta, and interleukin-6 in alveolar macrophages activated by lipopolysaccharide. Ambroxol 0-8 interleukin 1 beta Rattus norvegicus 97-114 12753420-2 2003 Ambroxol and erdosteine significantly decreased the production of tumour necrosis factors-alpha, interleukin-1beta, and interleukin-6 in alveolar macrophages activated by lipopolysaccharide. erdosteine 13-23 interleukin 1 beta Rattus norvegicus 97-114 12759126-10 2003 In both trials, interleukin-1beta (IL-1beta) levels were increased similarly in CFA-CON and CFA+IBU groups (P<.01). Ibuprofen 96-99 interleukin 1 beta Rattus norvegicus 35-43 12562859-0 2003 Different effects of n-6 and n-3 polyunsaturated fatty acids on the activation of rat smooth muscle cells by interleukin-1 beta. n-6 21-24 interleukin 1 beta Rattus norvegicus 109-127 12688550-2 2003 We hypothesized that enhancement of nitric oxide (NO) production in the presence of interleukin (IL)-1beta in hepatocytes, isolated under septic conditions, could be implicated in the change in liver energy metabolism, thus resulting in hepatocellular dysfunction. Nitric Oxide 36-48 interleukin 1 beta Rattus norvegicus 84-106 12688550-7 2003 IL-1beta markedly decreased cellular ATP content and KBR in the CLP group. Adenosine Triphosphate 37-40 interleukin 1 beta Rattus norvegicus 0-8 12688550-9 2003 In contrast, L-NMMA, an inhibitor of nitric oxide synthase, abolished the effects of IL-1beta on ATP content and KBR, as well as on NO production. omega-N-Methylarginine 13-19 interleukin 1 beta Rattus norvegicus 85-93 12688550-9 2003 In contrast, L-NMMA, an inhibitor of nitric oxide synthase, abolished the effects of IL-1beta on ATP content and KBR, as well as on NO production. Adenosine Triphosphate 97-100 interleukin 1 beta Rattus norvegicus 85-93 12857441-1 2003 OBJECTIVE: To study whether nimodipine, a dihydropyridine-type calcium channel blocker, can inhibit the production of interleukin-1beta(IL-1beta), interleukin-6(IL-6) by Kupffer cells(KC) and down-regulate its level of plasma after severe burn injury. Nimodipine 28-38 interleukin 1 beta Rattus norvegicus 118-135 12857441-1 2003 OBJECTIVE: To study whether nimodipine, a dihydropyridine-type calcium channel blocker, can inhibit the production of interleukin-1beta(IL-1beta), interleukin-6(IL-6) by Kupffer cells(KC) and down-regulate its level of plasma after severe burn injury. Nimodipine 28-38 interleukin 1 beta Rattus norvegicus 136-144 12857441-10 2003 At present of 1 micromol/L nimodipine, however, the [Ca2+]i, IL-1beta, IL-6 values decreased significantly(all P<0.01). Nimodipine 27-37 interleukin 1 beta Rattus norvegicus 61-69 12857441-13 2003 CONCLUSION: Kupffer cells of rats are activated to secret IL-1beta and IL-6 after severe burn injury and this process is realized through calcium ion signal transduction channel. Calcium 138-145 interleukin 1 beta Rattus norvegicus 58-66 12857441-14 2003 Nimodipine can inhibit IL-1beta and IL-6 production of KC by preventing its mRNA transcription, down-regulating its level of plasma. Nimodipine 0-10 interleukin 1 beta Rattus norvegicus 23-31 12627004-1 2003 OBJECTIVES: This study examined the effects of interleukin-1 beta on isometric tension development and relaxation in isolated rat aortic rings in response to the alpha-1 adrenergic agonist phenylephrine, the endothelium-dependent vasodilator acetylcholine, and the endothelium-independent vasodilator sodium nitroprusside. Phenylephrine 189-202 interleukin 1 beta Rattus norvegicus 47-65 12627004-13 2003 Dactinomycin pretreatment inhibited early interleukin-1 beta-mediated endothelial dysfunction. Dactinomycin 0-12 interleukin 1 beta Rattus norvegicus 42-60 12627004-15 2003 Interleukin-1 beta attenuated responsiveness to sodium nitroprusside relative to control. Nitroprusside 48-68 interleukin 1 beta Rattus norvegicus 0-18 12627004-18 2003 The altered vasorelaxation induced by interleukin-1 beta is at least partly mediated by a reduction in nitric oxide responsiveness. Nitric Oxide 103-115 interleukin 1 beta Rattus norvegicus 38-56 12562859-7 2003 EPA and DHA also abolished proinflammatory prostaglandin PGE2 production by inhibiting the IL1 beta-induced production of cyclooxygenase-2 (COX-2) mRNA. Eicosapentaenoic Acid 0-3 interleukin 1 beta Rattus norvegicus 91-99 12562859-7 2003 EPA and DHA also abolished proinflammatory prostaglandin PGE2 production by inhibiting the IL1 beta-induced production of cyclooxygenase-2 (COX-2) mRNA. Docosahexaenoic Acids 8-11 interleukin 1 beta Rattus norvegicus 91-99 12562859-7 2003 EPA and DHA also abolished proinflammatory prostaglandin PGE2 production by inhibiting the IL1 beta-induced production of cyclooxygenase-2 (COX-2) mRNA. Prostaglandins 43-56 interleukin 1 beta Rattus norvegicus 91-99 12562859-7 2003 EPA and DHA also abolished proinflammatory prostaglandin PGE2 production by inhibiting the IL1 beta-induced production of cyclooxygenase-2 (COX-2) mRNA. Dinoprostone 57-61 interleukin 1 beta Rattus norvegicus 91-99 12562859-10 2003 These results indicate that EPA and DHA act in opposition to AA by modulating various steps of the inflammatory process induced by IL1 beta, probably by reducing mitogen-activated protein kinase p42/p44 activity. Eicosapentaenoic Acid 28-31 interleukin 1 beta Rattus norvegicus 131-139 12562859-10 2003 These results indicate that EPA and DHA act in opposition to AA by modulating various steps of the inflammatory process induced by IL1 beta, probably by reducing mitogen-activated protein kinase p42/p44 activity. Docosahexaenoic Acids 36-39 interleukin 1 beta Rattus norvegicus 131-139 12562859-0 2003 Different effects of n-6 and n-3 polyunsaturated fatty acids on the activation of rat smooth muscle cells by interleukin-1 beta. Fatty Acids, Omega-3 29-60 interleukin 1 beta Rattus norvegicus 109-127 12562859-3 2003 This study was designed to investigate the effects of membrane incorporation of two major components of fish oil [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], on rat smooth muscle cells (SMCs) activation induced by interleukin-1 beta (IL1 beta). Eicosapentaenoic Acid 114-135 interleukin 1 beta Rattus norvegicus 231-249 12562859-3 2003 This study was designed to investigate the effects of membrane incorporation of two major components of fish oil [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)], on rat smooth muscle cells (SMCs) activation induced by interleukin-1 beta (IL1 beta). Docosahexaenoic Acids 146-166 interleukin 1 beta Rattus norvegicus 231-249 12667918-4 2003 IP 8-OH-DPAT attenuated ICV IL-1 beta-induced anorexia (P<.01). 8-Hydroxy-2-(di-n-propylamino)tetralin 3-12 interleukin 1 beta Rattus norvegicus 28-37 12708746-1 2003 The norepinephrine (NE)-induced hypertrophy of the left ventricle (LV) in the rat is associated with increased interleukin (IL)-6 and IL-1beta expression. Norepinephrine 4-18 interleukin 1 beta Rattus norvegicus 134-142 12667918-7 2003 Median raphe injections of 8-OH-DPAT significantly attenuated both IL-1 beta- and LPS-induced anorexia (both P<.01). 8-Hydroxy-2-(di-n-propylamino)tetralin 27-36 interleukin 1 beta Rattus norvegicus 67-76 12509805-1 2003 Expression of inducible nitric oxide synthase (iNOS), which leads to the production of nitric oxide (NO), is stimulated by proinflammatory cytokines such as interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha). Nitric Oxide 24-36 interleukin 1 beta Rattus norvegicus 157-174 12535733-5 2003 Treatment of VSMCs with cerivastatin (10(-7)-10(-5) mol/l), which inhibits isoprenylation of Rho and other small G proteins, significantly increased nitrite/nitrate (NOx) production and upregulated the expression of iNOS mRNA in IL-1beta-stimulated VSMCs. cerivastatin 24-36 interleukin 1 beta Rattus norvegicus 229-237 12535733-7 2003 Furthermore, C3 exoenzyme (50 microg/ml), an inactivator of Rho protein, and Rho kinase inhibitor Y-27632 (10(-5) mol/l) also enhanced NOx production and the expression of iNOS mRNA in IL-1beta-stimulated VSMCs. Y 27632 98-105 interleukin 1 beta Rattus norvegicus 185-193 12535733-9 2003 Our study suggests that cerivastatin stimulates iNOS expression in IL-1beta treated VSMCs by its inhibitory effect on Rho/Rho kinase pathway. cerivastatin 24-36 interleukin 1 beta Rattus norvegicus 67-75 12598422-12 2003 15d-PGJ(2) also caused a substantial reduction of (i) the degree of colonic injury, (ii) the rise in myeloperoxidase (MPO) activity (mucosa), (iii) the increase in the tissue levels of malondialdehyde (MDA) and (iv) of the pro-inflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). 15d-pgj 0-7 interleukin 1 beta Rattus norvegicus 295-312 12598422-12 2003 15d-PGJ(2) also caused a substantial reduction of (i) the degree of colonic injury, (ii) the rise in myeloperoxidase (MPO) activity (mucosa), (iii) the increase in the tissue levels of malondialdehyde (MDA) and (iv) of the pro-inflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). 15d-pgj 0-7 interleukin 1 beta Rattus norvegicus 314-322 12576959-13 2003 CONCLUSIONS: Endogenous nitric oxide may be an important endogenous inhibitor of hyperoxia + tumor necrosis factor-alpha-induced leukocyte recruitment and subsequently tumor necrosis factor-alpha, interleukin-1 beta, and GRO/CINC-1 release. Nitric Oxide 24-36 interleukin 1 beta Rattus norvegicus 197-215 12540607-10 2003 Blocking of NF-kappaB activation in cytokine-exposed primary beta-cells by an adenovirus overexpressing a nondegradable form of IkappaBalpha or by pyrrolidine dithiocarbamate decreased IL-1beta-induced MCP-1 mRNA expression. pyrrolidine dithiocarbamic acid 147-174 interleukin 1 beta Rattus norvegicus 185-193 12535154-3 2003 In response to 1 nm IL-1 beta, 65% of parvocellular neurones tested exhibited a clear depolarization, which was abolished in the presence of tetrodotoxin (TTX). Tetrodotoxin 141-153 interleukin 1 beta Rattus norvegicus 20-29 12535154-3 2003 In response to 1 nm IL-1 beta, 65% of parvocellular neurones tested exhibited a clear depolarization, which was abolished in the presence of tetrodotoxin (TTX). Tetrodotoxin 155-158 interleukin 1 beta Rattus norvegicus 20-29 12535154-6 2003 Bicuculline administration blocked the effects of IL-1 beta, suggesting that this cytokine modulates GABA-ergic output, resulting in a decrease in inhibitory input (IPSPs) and consequent depolarization. Bicuculline 0-11 interleukin 1 beta Rattus norvegicus 50-59 12535154-6 2003 Bicuculline administration blocked the effects of IL-1 beta, suggesting that this cytokine modulates GABA-ergic output, resulting in a decrease in inhibitory input (IPSPs) and consequent depolarization. gamma-Aminobutyric Acid 101-105 interleukin 1 beta Rattus norvegicus 50-59 12535154-7 2003 These data support the conclusion that IL-1 beta influences the excitability of parvocellular neurones in the PVN, as a secondary consequence of nitric oxide generation and modulation of GABAergic inhibitory input to these cells. Nitric Oxide 145-157 interleukin 1 beta Rattus norvegicus 39-48 12578124-8 2003 In contrast, oral administration of curcumin for 7 days followed by hemorrhage/resuscitation regimen resulted in significant restoration of these cytokines to depleted levels, and, in fact, IL-1beta levels were lower than sham levels. Curcumin 36-44 interleukin 1 beta Rattus norvegicus 190-198 12631052-8 2003 RESULTS: Both LPS and IL-1beta reduced contractility in response to phenylephrine and increased NO production as well as iNOS expression. Phenylephrine 68-81 interleukin 1 beta Rattus norvegicus 22-30 12371906-3 2003 Culture of rat cardiac fibroblasts for 24 h in 1% oxygen enhanced MMP-2 synthesis by more than 5-fold and augmented the MMP-2 synthetic responses of these cells to endothelin-1, angiotensin II and interleukin 1beta. Oxygen 50-56 interleukin 1 beta Rattus norvegicus 197-214 12423601-0 2003 IL-1alpha, IL-1beta and TNF-alpha secretion during in vivo/ex vivo cellular interactions with titanium and copper. Titanium 94-102 interleukin 1 beta Rattus norvegicus 11-19 12576959-12 2003 L-NAME significantly enhanced the percentage of neutrophil recovery and the production of tumor necrosis factor-alpha, interleukin-1 beta, and GRO/CINC-1 in airways compared with the corresponding hyperoxia + tumor necrosis factor-alpha treatment alone. NG-Nitroarginine Methyl Ester 0-6 interleukin 1 beta Rattus norvegicus 119-137 12653206-6 2003 Allopurinol, the competitive inhibitor of XO, also caused a dose related (1-50 microM) inhibition of TNFalpha (20 ng/ml) and (0.01-10 microM) IL-1beta (50 IU/ml)-induced bone resorption, respectively. Allopurinol 0-11 interleukin 1 beta Rattus norvegicus 142-150 12459927-5 2003 Using this schedule, it was then possible to assess the influence of chronic fluoxetine in attenuating the effects of IL-1beta. Fluoxetine 77-87 interleukin 1 beta Rattus norvegicus 118-126 12459927-6 2003 METHODS: The effect of a single intraperitoneal injection of IL-1beta treatment was assessed in rats trained to respond on a PR schedule for sucrose reward, and who could obtain ad lib chow. Sucrose 141-148 interleukin 1 beta Rattus norvegicus 61-69 12459927-8 2003 RESULTS: A single intraperitoneal injection of IL-1beta reduced chow consumption for 48 h in both males and females; in contrast, among males, the effort expended to gain sucrose reward was reduced for 24 h, while in females the effect persisted for 72 h. Chronic pretreatment with fluoxetine attenuated the disturbance of PR performance elicited by IL-1beta, but did not alter the reduced chow consumption. Sucrose 171-178 interleukin 1 beta Rattus norvegicus 47-55 12459927-8 2003 RESULTS: A single intraperitoneal injection of IL-1beta reduced chow consumption for 48 h in both males and females; in contrast, among males, the effort expended to gain sucrose reward was reduced for 24 h, while in females the effect persisted for 72 h. Chronic pretreatment with fluoxetine attenuated the disturbance of PR performance elicited by IL-1beta, but did not alter the reduced chow consumption. Fluoxetine 282-292 interleukin 1 beta Rattus norvegicus 47-55 12509805-1 2003 Expression of inducible nitric oxide synthase (iNOS), which leads to the production of nitric oxide (NO), is stimulated by proinflammatory cytokines such as interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha). Nitric Oxide 24-36 interleukin 1 beta Rattus norvegicus 176-184 12509805-6 2003 By contrast, the selective p38 kinase inhibitor SB203,580 amplified the effects of IL-1beta/TNF-alpha on nitrite accumulation. sb203 48-53 interleukin 1 beta Rattus norvegicus 83-91 12509805-6 2003 By contrast, the selective p38 kinase inhibitor SB203,580 amplified the effects of IL-1beta/TNF-alpha on nitrite accumulation. Nitrites 105-112 interleukin 1 beta Rattus norvegicus 83-91 12468033-4 2002 This study investigates the expression of the principal pro-inflammatory cytokines--IL-1beta and TNFalpha--in the brain after IL-1beta, TNFalpha, NMDA or endotoxin injection into the brain parenchyma of rats. N-Methylaspartate 146-150 interleukin 1 beta Rattus norvegicus 84-92 12637986-8 2003 However, long-term addition (24 h) of NNC 55-0118 counteracted IL-1beta induced inhibition of the glucose oxidation rate. Glucose 98-105 interleukin 1 beta Rattus norvegicus 63-71 12616337-0 2003 Interleukin 1 beta-induced inhibition of gastric acid secretion involves glutamate, NO and cGMP synthesis in the brain. Glutamic Acid 73-82 interleukin 1 beta Rattus norvegicus 0-18 12616337-0 2003 Interleukin 1 beta-induced inhibition of gastric acid secretion involves glutamate, NO and cGMP synthesis in the brain. Cyclic GMP 91-95 interleukin 1 beta Rattus norvegicus 0-18 12616337-1 2003 This study examines the role of a central pathway involving glutamate receptors, nitric oxide (NO) and cGMP in the acute inhibitory effects of central interleukin 1beta on pentagastrin-stimulated acid production.The acid-inhibitory effect of central interleukin 1beta was prevented by intracisternal (i.c.) Cyclic GMP 103-107 interleukin 1 beta Rattus norvegicus 151-168 12616337-1 2003 This study examines the role of a central pathway involving glutamate receptors, nitric oxide (NO) and cGMP in the acute inhibitory effects of central interleukin 1beta on pentagastrin-stimulated acid production.The acid-inhibitory effect of central interleukin 1beta was prevented by intracisternal (i.c.) Pentagastrin 172-184 interleukin 1 beta Rattus norvegicus 151-168 12617945-7 2003 Dexamethasone (1 mg/kg s.c. at -18 h and -1 h) attenuated the effect endotoxin on the expression of interleukin-1beta, cyclooxygenase-2, and membrane bound prostaglandin E synthase messenger RNA in all tissues investigated, but did not significantly influence expression of lipocalin prostaglandin D synthase mRNA in spinal cord and dorsal root ganglia. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 100-117 12903836-5 2003 The rate of glucose oxidation (pmol/10 islets x 90 min) was suppressed by IL-1beta (115 +/- 17 vs. control 380 +/- 57). Glucose 12-19 interleukin 1 beta Rattus norvegicus 74-82 12903836-8 2003 MG115 (10 microM) and norLEU (100 microM) blocked nitric oxide formation induced by IL-1beta, while alIMET was without effect. carbobenzoxy-leucyl-leucyl-norvalinal 0-5 interleukin 1 beta Rattus norvegicus 84-92 12903836-8 2003 MG115 (10 microM) and norLEU (100 microM) blocked nitric oxide formation induced by IL-1beta, while alIMET was without effect. norleu 22-28 interleukin 1 beta Rattus norvegicus 84-92 12903836-8 2003 MG115 (10 microM) and norLEU (100 microM) blocked nitric oxide formation induced by IL-1beta, while alIMET was without effect. Nitric Oxide 50-62 interleukin 1 beta Rattus norvegicus 84-92 12903836-9 2003 We also investigated if IL-1beta could influence the expression of two inducible proteasome subunits, namely LMP2 and LMP7, and found that the cytokine increased the mRNA expression of the proteasome subunit LMP2 in islets, and that the proteasome inhibitor MG115 prevented this increase. carbobenzoxy-leucyl-leucyl-norvalinal 258-263 interleukin 1 beta Rattus norvegicus 24-32 12903836-11 2003 Moreover, the observation that inhibitors of the proteasome protect islets against IL-1beta induced inhibition of glucose metabolism, suggests that these compounds might be worthwile to explore in future therapies against the development of type 1 diabetes. Glucose 114-121 interleukin 1 beta Rattus norvegicus 83-91 12468033-6 2002 Injection of NMDA results in IL-1beta, but not TNFalpha up-regulation. N-Methylaspartate 13-17 interleukin 1 beta Rattus norvegicus 29-37 12475221-0 2002 Suppression of interleukin-1 beta-induced nitric oxide production in RINm5F cells by inhibition of glucose-6-phosphate dehydrogenase. Nitric Oxide 42-54 interleukin 1 beta Rattus norvegicus 15-33 12475221-1 2002 In rat pancreatic islets and insulin-producing cell lines, IL-1beta induces expression of inducible nitric oxide synthase and NO production leading to impairment of glucose-stimulated insulin release and decreased cell survival. Glucose 165-172 interleukin 1 beta Rattus norvegicus 59-67 12475221-3 2002 We hypothesized that IL-1beta stimulates an increase in activity of NADPH-producing enzyme(s) prior to NO production and that this increase is necessary for NO production. NADP 68-73 interleukin 1 beta Rattus norvegicus 21-29 12475221-6 2002 In conclusion, our data show that IL-1beta stimulated G6PD activity and expression level, providing NADPH that is required by iNOS for NO production in RINm5F cells. NADP 100-105 interleukin 1 beta Rattus norvegicus 34-42 12475221-7 2002 Also, inhibition of the cAMP-dependent PKA signal pathway is involved in an IL-1beta-stimulated increase in G6PD activity. Cyclic AMP 24-28 interleukin 1 beta Rattus norvegicus 76-84 12699771-3 2003 Here, the effects of the novel JNK inhibitor anthra[1,9-cd]pyrazol-6(2H)-1 (SP600125) were investigated on the inhibition of LTP by cytokines interleukin-1beta, interleukin-18 and tumour necrosis factor-alpha in the dentate gyrus. anthra[1,9-cd]pyrazol-6(2h)-1 45-74 interleukin 1 beta Rattus norvegicus 142-159 12699771-3 2003 Here, the effects of the novel JNK inhibitor anthra[1,9-cd]pyrazol-6(2H)-1 (SP600125) were investigated on the inhibition of LTP by cytokines interleukin-1beta, interleukin-18 and tumour necrosis factor-alpha in the dentate gyrus. pyrazolanthrone 76-84 interleukin 1 beta Rattus norvegicus 142-159 12688637-0 2002 IL-1beta-induced nitric oxide release from insulin-secreting beta-cells: further evidence for the involvement of GTP-binding proteins. Nitric Oxide 17-29 interleukin 1 beta Rattus norvegicus 0-8 12688637-0 2002 IL-1beta-induced nitric oxide release from insulin-secreting beta-cells: further evidence for the involvement of GTP-binding proteins. Guanosine Triphosphate 113-116 interleukin 1 beta Rattus norvegicus 0-8 12688637-5 2002 For example, IL-1beta treatment resulted in significant reduction in (high-and low-affinity) GTPase activities in lysates derived from normal rat islets; such a scenario might lead to retention of candidate G-proteins in GTP-bound, active conformation. Guanosine Triphosphate 93-96 interleukin 1 beta Rattus norvegicus 13-21 12438508-2 2002 The hypothesis tested herein was that overexpression of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha mediates these deleterious effects of ethanol on the rat skeleton. Ethanol 155-162 interleukin 1 beta Rattus norvegicus 56-78 12451324-11 2002 Interleukin-1beta-stimulated H-leucine incorporation was completely inhibited by fluvastatin, but not by pravastatin. Leucine 31-38 interleukin 1 beta Rattus norvegicus 0-17 12451324-11 2002 Interleukin-1beta-stimulated H-leucine incorporation was completely inhibited by fluvastatin, but not by pravastatin. Fluvastatin 81-92 interleukin 1 beta Rattus norvegicus 0-17 12558194-11 2002 Treatment of animals with CLX or RFX did not alter the content of pro-inflammatory cytokines IL-1beta or TNF-alpha in the pleural exudate, but CLX reduced IL-1beta levels in the rat paw tissue and RFX increased TNF-alpha in this tissue. Celecoxib 143-146 interleukin 1 beta Rattus norvegicus 155-163 12635866-7 2002 From these results, we conclude that the enhanced elevation of IL-1beta and TNF-alpha mRNA levels seen in LPS-stimulated alveolar macrophages in low-Mg2+ medium occurs partly via the same, and partly via different, signaling pathways. magnesium ion 149-153 interleukin 1 beta Rattus norvegicus 63-71 12465160-8 2002 Both in vitro and in vivo, peroxynitrite formation was extensive with IL-1beta, but negligible or nonexistent with IL-17. Peroxynitrous Acid 27-40 interleukin 1 beta Rattus norvegicus 70-78 12465160-9 2002 L-NMMA and CuDips completely corrected the suppressive effect of IL-1beta on proteoglycan synthesis, unlike with IL-17. omega-N-Methylarginine 0-6 interleukin 1 beta Rattus norvegicus 65-73 12478038-3 2002 This study was designed to determine the effects of IAH on the production of interleukin-1b (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), and the effects on remote organ injury. 3-iodo-4-azido-N-hexadecylsalicylamide 52-55 interleukin 1 beta Rattus norvegicus 77-91 12478038-3 2002 This study was designed to determine the effects of IAH on the production of interleukin-1b (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor (TNF-alpha), and the effects on remote organ injury. 3-iodo-4-azido-N-hexadecylsalicylamide 52-55 interleukin 1 beta Rattus norvegicus 93-101 12635865-0 2002 Effects of a low extracellular magnesium concentration and endotoxin on IL-1beta and TNF-alpha release from, and mRNA levels in, isolated rat alveolar macrophages. Magnesium 31-40 interleukin 1 beta Rattus norvegicus 72-80 12635865-5 2002 These results suggest that a low extracellular Mg2+ concentration and LPS stimulate the release of IL-1beta and TNF-alpha from rat alveolar macrophages by increasing the synthesis of both cytokines and by Ca2+ signaling pathways. magnesium ion 47-51 interleukin 1 beta Rattus norvegicus 99-107 12635866-0 2002 Mechanisms underlying the enhanced elevation of IL-1beta and TNF-alpha mRNA levels following endotoxin challenge in rat alveolar macrophages cultured with low-Mg2+ medium. magnesium ion 159-163 interleukin 1 beta Rattus norvegicus 48-56 12635866-1 2002 We have previously shown that interleukin (IL)-1beta and tumour necrosis factor (TNF)-alpha mRNA levels in rat alveolar macrophages are increased in by endotoxin (lipopolysaccharide; LPS)- stimulation and further enhanced by culturing with low-Mg2+ medium. magnesium ion 244-248 interleukin 1 beta Rattus norvegicus 30-52 12446178-0 2002 Arginase expression and modulation of IL-1beta-induced nitric oxide generation in rat and human islets of Langerhans. Nitric Oxide 55-67 interleukin 1 beta Rattus norvegicus 38-46 12507434-5 2002 Both ME and LE increased the baseline release of IL-1 beta, which was completely blocked by naloxone pretreatment. Naloxone 92-100 interleukin 1 beta Rattus norvegicus 49-58 12446178-6 2002 to investigate the competition for arginine between NO synthase and arginase in IL-1beta-treated rat islets. Arginine 35-43 interleukin 1 beta Rattus norvegicus 80-88 12446178-10 2002 IL-1beta-induced NO generation was unaffected by ABH at 1.14 mM arginine, but significantly increased at 0.1 and 0.01 mM arginine. Arginine 64-72 interleukin 1 beta Rattus norvegicus 0-8 12446178-10 2002 IL-1beta-induced NO generation was unaffected by ABH at 1.14 mM arginine, but significantly increased at 0.1 and 0.01 mM arginine. Arginine 121-129 interleukin 1 beta Rattus norvegicus 0-8 12426209-6 2002 Inhibition of ERK phosphorylation with selective inhibitors (PD98059 or U0126) attenuated interleukin-1beta-induced persistent NF-kappaB activation and iNOS expression in either the absence or presence of the growth factors. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 61-68 interleukin 1 beta Rattus norvegicus 90-107 12468262-4 2002 Meanwhile 1, 10 and 20 ng/ml of IL-1beta decreased progesterone (P4) production, only the highest doses of IL-1beta increased prostaglandin F2alpha (PGF2alpha) levels. Progesterone 51-63 interleukin 1 beta Rattus norvegicus 32-40 12468262-4 2002 Meanwhile 1, 10 and 20 ng/ml of IL-1beta decreased progesterone (P4) production, only the highest doses of IL-1beta increased prostaglandin F2alpha (PGF2alpha) levels. Dinoprost 126-147 interleukin 1 beta Rattus norvegicus 107-115 12468262-4 2002 Meanwhile 1, 10 and 20 ng/ml of IL-1beta decreased progesterone (P4) production, only the highest doses of IL-1beta increased prostaglandin F2alpha (PGF2alpha) levels. Dinoprost 149-158 interleukin 1 beta Rattus norvegicus 107-115 12433597-9 2002 administered interleukin-1beta (100 ng/animal) elevated plasma levels of noradrenaline but not adrenaline. Norepinephrine 73-86 interleukin 1 beta Rattus norvegicus 13-30 12433597-9 2002 administered interleukin-1beta (100 ng/animal) elevated plasma levels of noradrenaline but not adrenaline. Epinephrine 76-86 interleukin 1 beta Rattus norvegicus 13-30 12468262-6 2002 We found that P4 inhibition induced by IL-1beta was completely prevented by addition of indomethacin. Indomethacin 88-100 interleukin 1 beta Rattus norvegicus 39-47 12468262-7 2002 On the other hand, when ovarian rat tissue were exposed at 20 ng/ml of IL-1beta (doses that affected both PGF2alpha and P4 production) the nitric oxide synthase (NOS) activity was augmented. Dinoprost 106-115 interleukin 1 beta Rattus norvegicus 71-79 12468262-8 2002 Moreover, IL-1beta effects on PGF2alpha and P4 levels were impaired when a NOS inhibitor N(W)-nitro- L -arginine methyl ester (L-NAME, 600 microM) was added to the incubation media. Dinoprost 30-39 interleukin 1 beta Rattus norvegicus 10-18 12468262-8 2002 Moreover, IL-1beta effects on PGF2alpha and P4 levels were impaired when a NOS inhibitor N(W)-nitro- L -arginine methyl ester (L-NAME, 600 microM) was added to the incubation media. n(w)-nitro- l -arginine methyl ester 89-125 interleukin 1 beta Rattus norvegicus 10-18 12468262-8 2002 Moreover, IL-1beta effects on PGF2alpha and P4 levels were impaired when a NOS inhibitor N(W)-nitro- L -arginine methyl ester (L-NAME, 600 microM) was added to the incubation media. NG-Nitroarginine Methyl Ester 127-133 interleukin 1 beta Rattus norvegicus 10-18 12445584-1 2002 We examined the immunomodulatory potential of acute fenfluramine administration, by measuring production of the pro-inflammatory cytokines interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha in response to an in vivo challenge with bacterial lipopolysaccharide in rats. Fenfluramine 52-64 interleukin 1 beta Rattus norvegicus 139-161 12445584-2 2002 Fenfluramine (2.5-10 mg/kg) suppressed tumor necrosis factor-alpha production, but only fenfluramine (5 and 10 mg/kg) suppressed interleukin-1beta production. Fenfluramine 88-100 interleukin 1 beta Rattus norvegicus 129-146 12445584-3 2002 Fenfluramine (10 mg/kg)-induced suppression of interleukin-1beta and tumor necrosis factor-alpha production persisted for 6 and 24 h, respectively. Fenfluramine 0-12 interleukin 1 beta Rattus norvegicus 47-96 12413956-7 2002 Similar to exogenously added ceramide, also interleukin-1beta which is an established activator of the neutral sphingomyelinase that leads to endogenous ceramide formation upregulates LIMK-1 protein expression and activity. Ceramides 29-37 interleukin 1 beta Rattus norvegicus 44-61 12413956-7 2002 Similar to exogenously added ceramide, also interleukin-1beta which is an established activator of the neutral sphingomyelinase that leads to endogenous ceramide formation upregulates LIMK-1 protein expression and activity. Ceramides 153-161 interleukin 1 beta Rattus norvegicus 44-61 12411406-6 2002 Both 6(5H)-phenanthridinone and benzamide attenuated development of EAE, reducing clinical score, neuroimmune infiltration and expression of inflammatory mediators such as inducible nitric oxide synthase, interleukin-1beta and -2, cyclooxygenase-2, tumour necrosis factor-alpha and interferon-gamma in the spinal cord of myelin-immunized rats. phenanthridone 5-27 interleukin 1 beta Rattus norvegicus 205-229 12411406-6 2002 Both 6(5H)-phenanthridinone and benzamide attenuated development of EAE, reducing clinical score, neuroimmune infiltration and expression of inflammatory mediators such as inducible nitric oxide synthase, interleukin-1beta and -2, cyclooxygenase-2, tumour necrosis factor-alpha and interferon-gamma in the spinal cord of myelin-immunized rats. benzamide 32-41 interleukin 1 beta Rattus norvegicus 205-229 12426209-6 2002 Inhibition of ERK phosphorylation with selective inhibitors (PD98059 or U0126) attenuated interleukin-1beta-induced persistent NF-kappaB activation and iNOS expression in either the absence or presence of the growth factors. U 0126 72-77 interleukin 1 beta Rattus norvegicus 90-107 12517731-4 2002 Conversely, IL-1beta-evoked hypersensitivity was inhibited (76%) by local pre-treatment of the animals with indomethacin, but not by atenolol. Indomethacin 108-120 interleukin 1 beta Rattus norvegicus 12-20 12390534-4 2002 While the induction of IL-1beta expression by lipopolysaccharide or by IL-1beta itself was very sensitive to nuclear factor kappa B (NF-kappaB) inhibitors, chlomethiazole or SB203580 were nearly without effect, indicating a differential regulation as compared to peripheral cells, e.g. monocytes. chlomethiazole 156-170 interleukin 1 beta Rattus norvegicus 23-31 12390534-4 2002 While the induction of IL-1beta expression by lipopolysaccharide or by IL-1beta itself was very sensitive to nuclear factor kappa B (NF-kappaB) inhibitors, chlomethiazole or SB203580 were nearly without effect, indicating a differential regulation as compared to peripheral cells, e.g. monocytes. SB 203580 174-182 interleukin 1 beta Rattus norvegicus 23-31 12390534-4 2002 While the induction of IL-1beta expression by lipopolysaccharide or by IL-1beta itself was very sensitive to nuclear factor kappa B (NF-kappaB) inhibitors, chlomethiazole or SB203580 were nearly without effect, indicating a differential regulation as compared to peripheral cells, e.g. monocytes. SB 203580 174-182 interleukin 1 beta Rattus norvegicus 71-79 12390534-5 2002 In contrast, chlomethiazole and SB203580 potently inhibited the IL-1beta-induced expression of c-fos and inducible nitric oxide synthase, as monitored by northern blot and quantitative RT-PCR, respectively. chlomethiazole 13-27 interleukin 1 beta Rattus norvegicus 64-72 12390534-5 2002 In contrast, chlomethiazole and SB203580 potently inhibited the IL-1beta-induced expression of c-fos and inducible nitric oxide synthase, as monitored by northern blot and quantitative RT-PCR, respectively. SB 203580 32-40 interleukin 1 beta Rattus norvegicus 64-72 12390534-6 2002 Because IL-1beta-induced expression of c-fos and inducible nitric oxide synthase is believed to directly contribute to the pathology of cerebral ischaemic injury, the results suggest a direct mechanism for the neuroprotective effects of chlomethiazole and SB203580, and further establish the anti-inflammatory properties of chlomethiazole. chlomethiazole 237-251 interleukin 1 beta Rattus norvegicus 8-16 12390534-6 2002 Because IL-1beta-induced expression of c-fos and inducible nitric oxide synthase is believed to directly contribute to the pathology of cerebral ischaemic injury, the results suggest a direct mechanism for the neuroprotective effects of chlomethiazole and SB203580, and further establish the anti-inflammatory properties of chlomethiazole. SB 203580 256-264 interleukin 1 beta Rattus norvegicus 8-16 12390534-6 2002 Because IL-1beta-induced expression of c-fos and inducible nitric oxide synthase is believed to directly contribute to the pathology of cerebral ischaemic injury, the results suggest a direct mechanism for the neuroprotective effects of chlomethiazole and SB203580, and further establish the anti-inflammatory properties of chlomethiazole. chlomethiazole 324-338 interleukin 1 beta Rattus norvegicus 8-16 12491784-1 2002 The effects of sphingosine 1-phosphate (S1P) on nitric oxide (NO) production induced by interleukin (IL)-1 beta in cultured rat vascular smooth muscle cells (VSMCs) have been investigated. sphingosine 1-phosphate 15-38 interleukin 1 beta Rattus norvegicus 88-111 12491784-1 2002 The effects of sphingosine 1-phosphate (S1P) on nitric oxide (NO) production induced by interleukin (IL)-1 beta in cultured rat vascular smooth muscle cells (VSMCs) have been investigated. sphingosine 1-phosphate 40-43 interleukin 1 beta Rattus norvegicus 88-111 12491784-1 2002 The effects of sphingosine 1-phosphate (S1P) on nitric oxide (NO) production induced by interleukin (IL)-1 beta in cultured rat vascular smooth muscle cells (VSMCs) have been investigated. Nitric Oxide 48-60 interleukin 1 beta Rattus norvegicus 88-111 12491784-8 2002 These results suggest that S1P modulates IL-1 beta induction of NO production by rat VSMCs through multiple mechanisms, partially via Edg-3 and Edg-5 receptor subtypes coupled to PTX-sensitive G proteins. ptx 179-182 interleukin 1 beta Rattus norvegicus 41-50 12271472-3 2002 Stimulation of beta-ARs on microglia by norepinephrine (NE) resulted in an increase in the level of intracellular cAMP and the subsequent expression of interleukin-1beta mRNA. Norepinephrine 40-54 interleukin 1 beta Rattus norvegicus 152-169 12377622-3 2002 The changes in the histological morphology of the periodontium and the expression of IL-1beta in the PDLC and osteoblasts were observed in both normal rats and the rat models using HE staining and immunohistochemistry techniques. Helium 181-183 interleukin 1 beta Rattus norvegicus 85-93 12374772-1 2002 Brief applications of IL-1 beta to nociceptive neurons yielded a potentiation of heat-activated inward currents (Iheat) and a shift of activation threshold toward lower temperature without altering intracellular calcium levels. Calcium 212-219 interleukin 1 beta Rattus norvegicus 22-31 12374772-3 2002 The nonspecific protein kinase inhibitor staurosporine, the specific protein kinase C inhibitor bisindolylmaleimide BIM1, and the protein tyrosine kinase inhibitor genistein reduced the sensitizing effect of IL-1 beta whereas negative controls were ineffective. Staurosporine 41-54 interleukin 1 beta Rattus norvegicus 208-217 12374772-3 2002 The nonspecific protein kinase inhibitor staurosporine, the specific protein kinase C inhibitor bisindolylmaleimide BIM1, and the protein tyrosine kinase inhibitor genistein reduced the sensitizing effect of IL-1 beta whereas negative controls were ineffective. bisindolylmaleimide bim1 96-120 interleukin 1 beta Rattus norvegicus 208-217 12374772-3 2002 The nonspecific protein kinase inhibitor staurosporine, the specific protein kinase C inhibitor bisindolylmaleimide BIM1, and the protein tyrosine kinase inhibitor genistein reduced the sensitizing effect of IL-1 beta whereas negative controls were ineffective. Genistein 164-173 interleukin 1 beta Rattus norvegicus 208-217 12436339-7 2002 Comparison of IL-1beta exposed BB-DP and WF islets showed common changes in 14 proteins and several proteins influencing similar pathways, suggesting that similar routes in the two strains lead to beta-cell destruction. bb-dp 31-36 interleukin 1 beta Rattus norvegicus 14-22 12436339-8 2002 CONCLUSION/INTERPRETATION: We demonstrate that proteome analysis is a powerful tool to identify proteins and pathways in BB-DP rat islets exposed to IL-1beta. bb-dp 121-126 interleukin 1 beta Rattus norvegicus 149-157 12390534-0 2002 The neuroprotective agents chlomethiazole and SB203580 inhibit IL-1beta signalling but not its biosynthesis in rat cortical glial cells. chlomethiazole 27-41 interleukin 1 beta Rattus norvegicus 63-71 12390534-0 2002 The neuroprotective agents chlomethiazole and SB203580 inhibit IL-1beta signalling but not its biosynthesis in rat cortical glial cells. SB 203580 46-54 interleukin 1 beta Rattus norvegicus 63-71 12457245-10 2002 IL-1beta-treated cells had reduced responses to isoproterenol as evidenced by a lack of enhanced amplitude of contraction and a reduction in cAMP production. Isoproterenol 48-61 interleukin 1 beta Rattus norvegicus 0-8 12457245-10 2002 IL-1beta-treated cells had reduced responses to isoproterenol as evidenced by a lack of enhanced amplitude of contraction and a reduction in cAMP production. Cyclic AMP 141-145 interleukin 1 beta Rattus norvegicus 0-8 12457245-11 2002 IL-1beta decreased the expression of genes important to the regulation of calcium homeostasis (phospholamban, sarcoplasmic reticulum calcium ATPase) at both the transcript and protein level. Calcium 74-81 interleukin 1 beta Rattus norvegicus 0-8 12457245-13 2002 These results support the hypothesis that IL-1beta may play an important role in contractile dysfunction through alterations in calcium homeostasis. Calcium 128-135 interleukin 1 beta Rattus norvegicus 42-50 12237169-8 2002 RESULTS: Incubation of cardiac myocytes with interleukin-1beta (IL-1beta; 10 ng/ml) caused a significant increase in nitrite production. Nitrites 117-124 interleukin 1 beta Rattus norvegicus 45-62 12237169-8 2002 RESULTS: Incubation of cardiac myocytes with interleukin-1beta (IL-1beta; 10 ng/ml) caused a significant increase in nitrite production. Nitrites 117-124 interleukin 1 beta Rattus norvegicus 64-72 12237169-9 2002 CRP significantly increased the IL-1beta-induced nitrite production in a dose-dependent manner (10-100 microg/ml). Nitrites 49-56 interleukin 1 beta Rattus norvegicus 32-40 12395901-6 2002 After DSS was withdrawn, disease activity subsided gradually and HGF expression was significantly enhanced along with the augmented expression of IL-1beta, TNF-alpha, and cyclooxygenase-2, accompanied by an increased number of proliferating epithelial cells in colon. dss 6-9 interleukin 1 beta Rattus norvegicus 146-154 12370118-2 2002 In the present study, we tested a highly selective iNOS inhibitor, 1400 W, against interleukin-1beta (IL-1beta) induced suppression of rat pancreatic islets, and investigated whether 1400 W could prevent multiple low-dose streptozotocin (MLDS) induced diabetes in mice. N-((3-(aminomethyl)phenyl)methyl)ethanimidamide 67-73 interleukin 1 beta Rattus norvegicus 83-100 12517731-5 2002 Carrageenin- and TNF-alpha-evoked hypersensitivity were attenuated to about the same extent (50%) by antisera neutralising CINC-1 or IL-1beta. Carrageenan 0-11 interleukin 1 beta Rattus norvegicus 133-141 12433284-4 2002 On the other hand, we have shown previously that IL-1beta inhibits glucose absorption from the jejunum. Glucose 67-74 interleukin 1 beta Rattus norvegicus 49-57 12379511-6 2002 Blockade of endogenous ACTH release by administration of the synthetic glucocorticoid dexamethasone prevented the rIL-1 beta/LPS-mediated elevation of plasma cortisol, suggesting that IL-1 beta and LPS modulate cortisol secretion via effects at the level of the hypothalamic-pituitary axis. Dexamethasone 86-99 interleukin 1 beta Rattus norvegicus 114-124 12433284-8 2002 The results suggest that the diuretic and natriuretic effect of IL-1beta and its inhibitory effect on glucose absorption are all due to downregulation of the Na(+)/K(+) pump in the kidney and jejunum. Glucose 102-109 interleukin 1 beta Rattus norvegicus 64-72 12091394-0 2002 Apoptotic changes in the aged brain are triggered by interleukin-1beta-induced activation of p38 and reversed by treatment with eicosapentaenoic acid. Eicosapentaenoic Acid 128-149 interleukin 1 beta Rattus norvegicus 53-70 12354747-8 2002 In contrast, milrinone increased nuclear NFkappaB translocation, iNOS and COX-2 expression, and cardiomyocyte production of interleukin-1beta. Milrinone 13-22 interleukin 1 beta Rattus norvegicus 124-141 12091394-6 2002 These changes were coupled with an age-related deficit in long term potentiation in perforant path-granule cell synapses, while eicosapentaenoate treatment was associated with reversal of age-related changes in interleukin-1beta and p38 and with restoration of long term potentiation. Eicosapentaenoic Acid 128-145 interleukin 1 beta Rattus norvegicus 211-228 12091394-2 2002 This study investigated the possibility that treatment with the polyunsaturated fatty acid eicosapentaenoic acid might prevent interleukin-1beta-induced deterioration in neuronal function. Fatty Acids, Unsaturated 64-90 interleukin 1 beta Rattus norvegicus 127-144 12091394-2 2002 This study investigated the possibility that treatment with the polyunsaturated fatty acid eicosapentaenoic acid might prevent interleukin-1beta-induced deterioration in neuronal function. Eicosapentaenoic Acid 91-112 interleukin 1 beta Rattus norvegicus 127-144 12091394-4 2002 The data are consistent with the idea that activation of p38 plays a significant role in inducing the changes described since interleukin-1beta-induced activation of cytochrome c translocation and caspase-3 activation in cortical tissue in vitro were reversed by the p38 inhibitor SB203580. SB 203580 281-289 interleukin 1 beta Rattus norvegicus 126-143 12242464-3 2002 Lisofylline has previously been shown to block Th1 cell differentiation and to reduce IL-1 beta-induced dysfunction in rat islets. lisofylline 0-11 interleukin 1 beta Rattus norvegicus 86-95 12352050-13 2002 Tumor necrosis factor-alpha and interleukin-1beta concentrations in alveolar macrophage supernatants and lung homogenates were significantly higher with alpha-naphthylthiourea + granulocyte colony-stimulating factor than with either agent alone, and anti-tumor necrosis factor-alpha antibodies abolished granulocyte colony-stimulating factor-related exacerbation of alpha-naphthylthiourea-induced pulmonary edema. alpha-naphthyl thiourea 153-175 interleukin 1 beta Rattus norvegicus 32-49 12202119-7 2002 PPAR agonists 15d-PGJ(2) and GI262570 (10 microM) inhibited IL-1beta- and TNFalpha-induced proteoglycan degradation measured both before and after addition of APMA. 15d-pgj 14-21 interleukin 1 beta Rattus norvegicus 60-68 12218351-0 2002 Maternal adrenalectomy abrogates the effect of fetal alcohol exposure on the interleukin-1beta-induced febrile response: gender differences. Alcohols 53-60 interleukin 1 beta Rattus norvegicus 77-94 12218351-1 2002 Fetal alcohol exposure (FAE) has been shown to blunt the febrile component of the primary host-defense response to infection induced experimentally by systemic administration of interleukin (IL)-1beta. Alcohols 6-13 interleukin 1 beta Rattus norvegicus 178-200 12218351-2 2002 Given that maternal adrenalectomy (ADX) can prevent various postnatal effects of FAE, the present experiments were designed to determine whether maternal ADX would prevent the blunted IL-1beta-induced febrile response of fetal alcohol-exposed offspring and whether the effects of maternal ADX would be gender related. Alcohols 227-234 interleukin 1 beta Rattus norvegicus 184-192 12193539-7 2002 In contrast, COX2 mRNA is induced by IL-1beta at 6, 9, and 24 h. IL-1beta induction of IL mRNAs was in part significantly impaired in the presence of INDO or NS-398. Indomethacin 150-154 interleukin 1 beta Rattus norvegicus 37-45 12193539-7 2002 In contrast, COX2 mRNA is induced by IL-1beta at 6, 9, and 24 h. IL-1beta induction of IL mRNAs was in part significantly impaired in the presence of INDO or NS-398. Indomethacin 150-154 interleukin 1 beta Rattus norvegicus 65-73 12193539-10 2002 PGE(2), PGF(2alpha), and PGI(2) measurements show that IL-1beta treatment significantly increases progenitor Leydig cell production of these PGs. Prostaglandins E 0-3 interleukin 1 beta Rattus norvegicus 55-63 12193539-10 2002 PGE(2), PGF(2alpha), and PGI(2) measurements show that IL-1beta treatment significantly increases progenitor Leydig cell production of these PGs. Prostaglandins F 8-11 interleukin 1 beta Rattus norvegicus 55-63 12193539-10 2002 PGE(2), PGF(2alpha), and PGI(2) measurements show that IL-1beta treatment significantly increases progenitor Leydig cell production of these PGs. Prostaglandins I 25-28 interleukin 1 beta Rattus norvegicus 55-63 12193539-10 2002 PGE(2), PGF(2alpha), and PGI(2) measurements show that IL-1beta treatment significantly increases progenitor Leydig cell production of these PGs. Phosphatidylglycerols 141-144 interleukin 1 beta Rattus norvegicus 55-63 12456992-0 2002 An imidazoline compound completely counteracts interleukin-1[beta] toxic effects to rat pancreatic islet [beta] cells. Imidazolines 3-14 interleukin 1 beta Rattus norvegicus 47-65 12456992-10 2002 Hence, imidazoline compounds may protect beta cells against damage caused by IL-1beta-induced free oxygen and nitrogen radicals. Imidazolines 7-18 interleukin 1 beta Rattus norvegicus 77-85 12456992-10 2002 Hence, imidazoline compounds may protect beta cells against damage caused by IL-1beta-induced free oxygen and nitrogen radicals. Oxygen 99-105 interleukin 1 beta Rattus norvegicus 77-85 12456992-10 2002 Hence, imidazoline compounds may protect beta cells against damage caused by IL-1beta-induced free oxygen and nitrogen radicals. Nitrogen 110-118 interleukin 1 beta Rattus norvegicus 77-85 12202119-7 2002 PPAR agonists 15d-PGJ(2) and GI262570 (10 microM) inhibited IL-1beta- and TNFalpha-induced proteoglycan degradation measured both before and after addition of APMA. farglitazar 29-37 interleukin 1 beta Rattus norvegicus 60-68 12498315-12 2002 IL-1beta induced expression of intercellular adhesion molecule-1 and monocyte chemoattractant protein-1, both of which were abolished in the presence of pyrrolidine dithiocarbamate, a specific inhibitor of nuclear factor-kappaB activation. pyrrolidine dithiocarbamic acid 153-180 interleukin 1 beta Rattus norvegicus 0-8 12498315-13 2002 IL-1beta-induced monocyte chemoattractant protein-1 was partially inhibited by specific inhibitors of MAP kinase kinase (U0126) and of p38 MAP kinase (SB203580) whereas intercellular adhesion molecule-1 expression was not altered by the inhibitors. U 0126 121-126 interleukin 1 beta Rattus norvegicus 0-8 12183018-5 2002 Norepinephrine release in the MPA of control rats increased significantly at 1530, 1600, and 1630 h paralelling an increase in LH at 1600 h. In contrast, IL-1beta treatment blocked the LH surge and the rise in norepinephrine release in the MPA. Norepinephrine 0-14 interleukin 1 beta Rattus norvegicus 154-162 12498315-13 2002 IL-1beta-induced monocyte chemoattractant protein-1 was partially inhibited by specific inhibitors of MAP kinase kinase (U0126) and of p38 MAP kinase (SB203580) whereas intercellular adhesion molecule-1 expression was not altered by the inhibitors. SB 203580 151-159 interleukin 1 beta Rattus norvegicus 0-8 12183018-5 2002 Norepinephrine release in the MPA of control rats increased significantly at 1530, 1600, and 1630 h paralelling an increase in LH at 1600 h. In contrast, IL-1beta treatment blocked the LH surge and the rise in norepinephrine release in the MPA. Luteinizing Hormone 127-129 interleukin 1 beta Rattus norvegicus 154-162 12183018-5 2002 Norepinephrine release in the MPA of control rats increased significantly at 1530, 1600, and 1630 h paralelling an increase in LH at 1600 h. In contrast, IL-1beta treatment blocked the LH surge and the rise in norepinephrine release in the MPA. Norepinephrine 210-224 interleukin 1 beta Rattus norvegicus 154-162 12107056-6 2002 3-Isobutyl-1-methylxanthine, a nonspecific phosphodiesterase (PDE) inhibitor, and erythro-9-(2-hydroxy-3-nonyl)adenine, a specific inhibitor of the cGMP-stimulated PDE (PDE2), completely restore cAMP accumulation in sodium nitroprusside-treated fibroblasts and largely reverse the attenuated response in IL-1beta-treated fibroblasts. 9-(2-hydroxy-3-nonyl)adenine 82-118 interleukin 1 beta Rattus norvegicus 304-312 12163122-9 2002 Brain concentrations of proinflammatory cytokines [interleukin-1beta (IL-beta), interleukin-6 (IL-6), and macrophage inflammatory protein-2 (MIP-2)] were also reduced by urate and MnTBAP. Uric Acid 170-175 interleukin 1 beta Rattus norvegicus 51-68 12107056-0 2002 Attenuation of cAMP accumulation in adult rat cardiac fibroblasts by IL-1beta and NO: role of cGMP-stimulated PDE2. Cyclic AMP 15-19 interleukin 1 beta Rattus norvegicus 69-77 12147249-0 2002 Fatty acids potentiate interleukin-1beta toxicity in the beta-cell line INS-1E. Fatty Acids 0-11 interleukin 1 beta Rattus norvegicus 23-40 12147249-7 2002 L-NAME, an inhibitor of constitutive nitric oxide (NO) synthase, reduced the negative effects of IL-1beta per se but did not abolish the potentiating effects of FA. NG-Nitroarginine Methyl Ester 0-6 interleukin 1 beta Rattus norvegicus 97-105 12133574-0 2002 Inhibitory effects of intrathecally administered interleukin-1beta on carrageenan-induced hyperalgesia and spinal c-Fos expression in rats. Carrageenan 70-81 interleukin 1 beta Rattus norvegicus 49-66 12133574-11 2002 pre-injected IL-1beta significantly decreased the number of carrageenan-induced c-Fos-LI neurons in laminae I-II in the ipsilateral spinal cord and also inhibited the hyperalgesia induced by i.pl. Carrageenan 60-71 interleukin 1 beta Rattus norvegicus 13-21 12107056-1 2002 Treatment of cultured adult rat cardiac fibroblasts with interleukin-1beta (IL-1beta) induces the inducible nitric oxide synthase (iNOS) expression, increases nitric oxide (NO) and cGMP production, and attenuates cAMP accumulation in response to isoproterenol by ~50%. Nitric Oxide 108-120 interleukin 1 beta Rattus norvegicus 57-74 12107056-1 2002 Treatment of cultured adult rat cardiac fibroblasts with interleukin-1beta (IL-1beta) induces the inducible nitric oxide synthase (iNOS) expression, increases nitric oxide (NO) and cGMP production, and attenuates cAMP accumulation in response to isoproterenol by ~50%. Nitric Oxide 108-120 interleukin 1 beta Rattus norvegicus 76-84 12107056-1 2002 Treatment of cultured adult rat cardiac fibroblasts with interleukin-1beta (IL-1beta) induces the inducible nitric oxide synthase (iNOS) expression, increases nitric oxide (NO) and cGMP production, and attenuates cAMP accumulation in response to isoproterenol by ~50%. Cyclic GMP 181-185 interleukin 1 beta Rattus norvegicus 57-74 12107056-1 2002 Treatment of cultured adult rat cardiac fibroblasts with interleukin-1beta (IL-1beta) induces the inducible nitric oxide synthase (iNOS) expression, increases nitric oxide (NO) and cGMP production, and attenuates cAMP accumulation in response to isoproterenol by ~50%. Cyclic GMP 181-185 interleukin 1 beta Rattus norvegicus 76-84 12107056-1 2002 Treatment of cultured adult rat cardiac fibroblasts with interleukin-1beta (IL-1beta) induces the inducible nitric oxide synthase (iNOS) expression, increases nitric oxide (NO) and cGMP production, and attenuates cAMP accumulation in response to isoproterenol by ~50%. Cyclic AMP 213-217 interleukin 1 beta Rattus norvegicus 57-74 12107056-1 2002 Treatment of cultured adult rat cardiac fibroblasts with interleukin-1beta (IL-1beta) induces the inducible nitric oxide synthase (iNOS) expression, increases nitric oxide (NO) and cGMP production, and attenuates cAMP accumulation in response to isoproterenol by ~50%. Cyclic AMP 213-217 interleukin 1 beta Rattus norvegicus 76-84 12107056-1 2002 Treatment of cultured adult rat cardiac fibroblasts with interleukin-1beta (IL-1beta) induces the inducible nitric oxide synthase (iNOS) expression, increases nitric oxide (NO) and cGMP production, and attenuates cAMP accumulation in response to isoproterenol by ~50%. Isoproterenol 246-259 interleukin 1 beta Rattus norvegicus 57-74 12107056-1 2002 Treatment of cultured adult rat cardiac fibroblasts with interleukin-1beta (IL-1beta) induces the inducible nitric oxide synthase (iNOS) expression, increases nitric oxide (NO) and cGMP production, and attenuates cAMP accumulation in response to isoproterenol by ~50%. Isoproterenol 246-259 interleukin 1 beta Rattus norvegicus 76-84 12124194-1 2002 We investigated the contributions of forebrain, brain stem, and spinal neural circuits to interleukin (IL)-1beta-induced sympathetic nerve discharge (SND) responses in alpha-chloralose-anesthetized rats. Chloralose 168-184 interleukin 1 beta Rattus norvegicus 90-112 12110001-11 2002 The induction of the inducible NO-synthase by TNF-alpha, IL-1beta and LPS provoked a transient down-regulation of CTGF mRNA, an effect that could be partially overcome by pretreatment with the NOS-inhibitor Nomega-nitro-l-arginine methyl ester. NG-Nitroarginine Methyl Ester 207-243 interleukin 1 beta Rattus norvegicus 57-65 12160195-1 2002 Intrarenal injection of phenol in rats causes a persistent elevation in blood pressure (BP) and in norepinephrine (NE) secretion from the posterior hypothalamus (PH), and downregulation of neuronal nitric oxide synthase (nNOS) and interleukin-1beta (IL-1beta) in the PH. Phenol 24-30 interleukin 1 beta Rattus norvegicus 231-248 12160195-1 2002 Intrarenal injection of phenol in rats causes a persistent elevation in blood pressure (BP) and in norepinephrine (NE) secretion from the posterior hypothalamus (PH), and downregulation of neuronal nitric oxide synthase (nNOS) and interleukin-1beta (IL-1beta) in the PH. Phenol 24-30 interleukin 1 beta Rattus norvegicus 250-258 12160195-9 2002 Chronic renal injury caused by phenol was associated with decreased abundance of IL-1beta and nNOS in the PH. Phenol 31-37 interleukin 1 beta Rattus norvegicus 81-89 12160195-12 2002 Because NO and IL-1beta modulate SNS activity, the stimulatory action of phenol on the SNS could be mediated by downregulation of nNOS and IL-1beta in the brain. Phenol 73-79 interleukin 1 beta Rattus norvegicus 139-147 12200111-0 2002 Increase of nociceptive threshold induced by intrathecal injection of interleukin-1beta in normal and carrageenan inflammatory rat. Carrageenan 102-113 interleukin 1 beta Rattus norvegicus 70-87 12145332-6 2002 The IL-1beta-caused increase in DNA binding of both NF-kappaB and Ets-1 immunopositive complexes was substantially suppressed by dexamethasone as shown by EMSA. Dexamethasone 129-142 interleukin 1 beta Rattus norvegicus 4-12 12202007-6 2002 IL-1beta (10 ng/mL) inhibited albumin (-90%), urea (-40 to 50%), and IL-6-stimulated fibrinogen (-90%) secretion. Urea 46-50 interleukin 1 beta Rattus norvegicus 0-8 12202007-7 2002 The inhibitory effect of IL-1beta on urea secretion was dose-dependent. Urea 37-41 interleukin 1 beta Rattus norvegicus 25-33 12202007-8 2002 Furthermore, IL-1beta transiently stimulated nitric oxide (NO) synthesis; however, NO did not mediate the effect of IL-1beta on albumin and fibrinogen production, and played a minor role in IL-1beta-mediated urea synthesis suppression. Nitric Oxide 45-57 interleukin 1 beta Rattus norvegicus 13-21 12202007-8 2002 Furthermore, IL-1beta transiently stimulated nitric oxide (NO) synthesis; however, NO did not mediate the effect of IL-1beta on albumin and fibrinogen production, and played a minor role in IL-1beta-mediated urea synthesis suppression. Urea 208-212 interleukin 1 beta Rattus norvegicus 13-21 12145332-2 2002 In this study, we elucidated the mechanisms of dexamethasone-mediated suppression of matrix metalloproteinase-9 (MMP-9) expression triggered by IL-1beta in rat mesangial cells. Dexamethasone 47-60 interleukin 1 beta Rattus norvegicus 144-152 12097404-12 2002 These data suggest that the anti-inflammatory properties of ebselen are achieved through an inhibition of lung ICAM-1 expression possibly through an inhibition of TNF-alpha and IL-1 beta, which are potent neutrophil recruiting mediators and effective inducers of ICAM-1 expression. ebselen 60-67 interleukin 1 beta Rattus norvegicus 177-186 11955955-0 2002 Cilostazol enhances IL-1beta-induced NO production and apoptosis in rat vascular smooth muscle via PKA-dependent pathway. Cilostazol 0-10 interleukin 1 beta Rattus norvegicus 20-28 11955955-1 2002 Interleukin-1beta (IL-1beta) stimulates nitric oxide (NO) production and induces apoptosis in several tissues. Nitric Oxide 40-52 interleukin 1 beta Rattus norvegicus 0-17 11955955-1 2002 Interleukin-1beta (IL-1beta) stimulates nitric oxide (NO) production and induces apoptosis in several tissues. Nitric Oxide 40-52 interleukin 1 beta Rattus norvegicus 19-27 11955955-3 2002 We investigated whether cilostazol affects IL-1beta-induced NO production and apoptosis in rat vascular smooth muscle cells. Cilostazol 24-34 interleukin 1 beta Rattus norvegicus 43-51 11955955-4 2002 Cilostazol (100 nM-10 microM) potentiated NO production triggered by IL-1beta. Cilostazol 0-10 interleukin 1 beta Rattus norvegicus 69-77 11955955-6 2002 KT5720, an inhibitor of protein kinase A, and N(G)-monomethyl-L-arginine, an inhibitor of NO synthase, abrogated cilostazol-enhanced IL-1beta-stimulated NO production and apoptosis. KT 5720 0-6 interleukin 1 beta Rattus norvegicus 133-141 11955955-6 2002 KT5720, an inhibitor of protein kinase A, and N(G)-monomethyl-L-arginine, an inhibitor of NO synthase, abrogated cilostazol-enhanced IL-1beta-stimulated NO production and apoptosis. omega-N-Methylarginine 46-72 interleukin 1 beta Rattus norvegicus 133-141 11955955-6 2002 KT5720, an inhibitor of protein kinase A, and N(G)-monomethyl-L-arginine, an inhibitor of NO synthase, abrogated cilostazol-enhanced IL-1beta-stimulated NO production and apoptosis. Cilostazol 113-123 interleukin 1 beta Rattus norvegicus 133-141 11955955-7 2002 These results shows that cilostazol potentiates IL-1beta-induced NO production via PKA-pathway and thereafter augments apoptosis via NO-dependent pathway. Cilostazol 25-35 interleukin 1 beta Rattus norvegicus 48-56 12231480-7 2002 IL-1beta reduced the net absorption of water and chloride. Chlorides 49-57 interleukin 1 beta Rattus norvegicus 0-8 12231480-7 2002 IL-1beta reduced the net absorption of water and chloride. Water 39-44 interleukin 1 beta Rattus norvegicus 0-8 12231480-9 2002 In addition IL-1beta decreased the protein expression of the Na(+)-K(+) pump and increased that of the NaKCl(2) symporter. nakcl(2) 103-111 interleukin 1 beta Rattus norvegicus 12-20 12231480-10 2002 It is concluded that IL-1beta has a dual effect: it inhibits the Na(+)-K(+) pump and consequently NaCl absorption, and up-regulates the NaKCl(2) transporter and increases Cl(-) secretion. Sodium Chloride 98-102 interleukin 1 beta Rattus norvegicus 21-29 12127805-4 2002 We previously reported that proinflammatory cytokine interleukin-1beta (IL-1beta) stimulated the production of nitric oxide in hepatocytes, which was associated with mitochondrial dysfunction. Nitric Oxide 111-123 interleukin 1 beta Rattus norvegicus 53-70 12070215-6 2002 3) Hypothermia after IL-1beta significantly reduced the coupling (0-2 Hz and CF) between renal-IBAT but not splenic-lumbar SND bursts. ibat 95-99 interleukin 1 beta Rattus norvegicus 21-29 12070215-7 2002 4) Combining IL-1beta and mild hypothermia had a greater effect on renal-IBAT SND coherence values than did mild hypothermia alone. ibat 73-77 interleukin 1 beta Rattus norvegicus 13-21 12127805-4 2002 We previously reported that proinflammatory cytokine interleukin-1beta (IL-1beta) stimulated the production of nitric oxide in hepatocytes, which was associated with mitochondrial dysfunction. Nitric Oxide 111-123 interleukin 1 beta Rattus norvegicus 72-80 12127805-8 2002 RESULTS: Hepatocytes obtained from obstructive jaundice rats markedly increased the levels of nitric oxide production stimulated by IL-1beta compared with those from sham control. Nitric Oxide 94-106 interleukin 1 beta Rattus norvegicus 132-140 12127805-10 2002 IL-1beta decreased cellular ATP content in obstructive jaundice but not in sham control. Adenosine Triphosphate 28-31 interleukin 1 beta Rattus norvegicus 0-8 12093444-10 2002 RESULTS: The results showed that interleukin-1beta and tumor necrosis factor-alpha concentrations in peritoneal lavage fluid at 6 h and interleukin-6 levels at 24 h after CLP in the Gly group were significantly higher than those in the Arg group. Glycine 182-185 interleukin 1 beta Rattus norvegicus 33-82 12055140-6 2002 IL-1beta-induced iNOS protein expression was significantly inhibited by PD 98059 (10 microM), a selective inhibitor of p44/42 MAPK kinase, both in the absence and the presence of DHA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 72-80 interleukin 1 beta Rattus norvegicus 0-8 12037376-0 2002 Interleukin-1beta-induced increases of plasma catecholamine levels in rats: enhancement by superior cervical ganglionectomy. Catecholamines 46-59 interleukin 1 beta Rattus norvegicus 0-17 12037376-1 2002 In urethane-anesthetized rats, we examined the effect of bilateral superior cervical ganglionectomy on interleukin-1beta (IL-1beta)-induced elevation of plasma catecholamines. Catecholamines 160-174 interleukin 1 beta Rattus norvegicus 103-120 12037376-1 2002 In urethane-anesthetized rats, we examined the effect of bilateral superior cervical ganglionectomy on interleukin-1beta (IL-1beta)-induced elevation of plasma catecholamines. Catecholamines 160-174 interleukin 1 beta Rattus norvegicus 122-130 12037376-3 2002 administered IL-1beta (100 ng/animal) effectively elevated plasma noradrenaline rather than plasma adrenaline. Norepinephrine 66-79 interleukin 1 beta Rattus norvegicus 13-21 12037376-3 2002 administered IL-1beta (100 ng/animal) effectively elevated plasma noradrenaline rather than plasma adrenaline. Epinephrine 69-79 interleukin 1 beta Rattus norvegicus 13-21 12037376-4 2002 In superior cervical ganglionectomized rats, however, IL-1beta significantly elevated adrenaline to a greater extent than noradrenaline, and they were attenuated by i.c.v. Epinephrine 86-96 interleukin 1 beta Rattus norvegicus 54-62 12020869-6 2002 Moreover, enhanced OT secretion induced by centrally administered IL-1beta, but not naloxone (opiate receptor antagonist), is prevented by indomethacin. Indomethacin 139-151 interleukin 1 beta Rattus norvegicus 66-74 12009687-0 2002 Cyclic estradiol treatment enhances the effects of interleukin-1beta on food intake in female rats. cyclic estradiol 0-16 interleukin 1 beta Rattus norvegicus 51-68 12009687-6 2002 The results indicate that a cyclic pattern of estradiol treatment enhances the anorectic effect of IL-1beta and suggest that responses to immune system activation are influenced by estradiol. Estradiol 46-55 interleukin 1 beta Rattus norvegicus 99-107 12132579-3 2002 NO production (NO2-), indicating iNOS activity, was much higher in the young rat hepatocytes following stimulation with LPS or IL-1beta. Nitrogen Dioxide 15-18 interleukin 1 beta Rattus norvegicus 127-135 12055140-0 2002 Docosahexaenoic acid potentiates interleukin-1beta induction of nitric oxide synthase through mechanism involving p44/42 MAPK activation in rat vascular smooth muscle cells. Docosahexaenoic Acids 0-20 interleukin 1 beta Rattus norvegicus 33-50 12055140-1 2002 The effect of docosahexaenoic acid (DHA) on nitric oxide (NO) production and inducible NO synthase (iNOS) expression induced by interleukin (IL)-1beta, and whether the effect of DHA is related to its effect on mitogen-activated protein kinase (MAPK) activation were investigated in cultured rat vascular smooth muscle cells (VSMCs). Docosahexaenoic Acids 14-34 interleukin 1 beta Rattus norvegicus 128-150 12055140-1 2002 The effect of docosahexaenoic acid (DHA) on nitric oxide (NO) production and inducible NO synthase (iNOS) expression induced by interleukin (IL)-1beta, and whether the effect of DHA is related to its effect on mitogen-activated protein kinase (MAPK) activation were investigated in cultured rat vascular smooth muscle cells (VSMCs). Docosahexaenoic Acids 36-39 interleukin 1 beta Rattus norvegicus 128-150 12055140-6 2002 IL-1beta-induced iNOS protein expression was significantly inhibited by PD 98059 (10 microM), a selective inhibitor of p44/42 MAPK kinase, both in the absence and the presence of DHA. Docosahexaenoic Acids 179-182 interleukin 1 beta Rattus norvegicus 0-8 12055140-2 2002 DHA and eicosapentaenoic acid (EPA), although less potent, increased the NO production induced by IL-1beta (3 ng ml(-1)) in a concentration-dependent manner (3 - 30 microM) Arachidonic acid had no significant effect. Docosahexaenoic Acids 0-3 interleukin 1 beta Rattus norvegicus 98-106 12055140-2 2002 DHA and eicosapentaenoic acid (EPA), although less potent, increased the NO production induced by IL-1beta (3 ng ml(-1)) in a concentration-dependent manner (3 - 30 microM) Arachidonic acid had no significant effect. Eicosapentaenoic Acid 8-29 interleukin 1 beta Rattus norvegicus 98-106 12055140-9 2002 DHA significantly potentiated the IL-1beta-induced phosphorylation of p44/42 MAPK, while it had no significant effect on the phosphorylation of p38 MAPK. Docosahexaenoic Acids 0-3 interleukin 1 beta Rattus norvegicus 34-42 12055140-2 2002 DHA and eicosapentaenoic acid (EPA), although less potent, increased the NO production induced by IL-1beta (3 ng ml(-1)) in a concentration-dependent manner (3 - 30 microM) Arachidonic acid had no significant effect. Eicosapentaenoic Acid 31-34 interleukin 1 beta Rattus norvegicus 98-106 12055140-2 2002 DHA and eicosapentaenoic acid (EPA), although less potent, increased the NO production induced by IL-1beta (3 ng ml(-1)) in a concentration-dependent manner (3 - 30 microM) Arachidonic acid had no significant effect. Arachidonic Acid 173-189 interleukin 1 beta Rattus norvegicus 98-106 12055140-10 2002 These results suggest that DHA increases NO production by potentiating iNOS expression induced by IL-1beta through mechanism involving p44/42 MAPK signalling cascade in rat VSMCs. Docosahexaenoic Acids 27-30 interleukin 1 beta Rattus norvegicus 98-106 12055140-3 2002 The stimulatory effect of DHA (30 microM) on the NO production was more obvious at lower concentrations of IL-1beta. Docosahexaenoic Acids 26-29 interleukin 1 beta Rattus norvegicus 107-115 12021199-2 2002 Lisofylline (LSF), an anti-inflammatory agent, has been shown to protect pancreatic islets from IL-1 beta-induced inhibitory effects on insulin release. lisofylline 0-11 interleukin 1 beta Rattus norvegicus 96-105 12055140-4 2002 IL-1beta induced iNOS protein and mRNA expressions, which were significantly potentiated by DHA. Docosahexaenoic Acids 92-95 interleukin 1 beta Rattus norvegicus 0-8 12021199-2 2002 Lisofylline (LSF), an anti-inflammatory agent, has been shown to protect pancreatic islets from IL-1 beta-induced inhibitory effects on insulin release. lisofylline 13-16 interleukin 1 beta Rattus norvegicus 96-105 12081657-4 2002 Analysis of colocalization of activated caspase-3 with activated p38 (p-p38) suggested that p-p38 was necessary for activation of caspase-3; while in vitro analysis indicated that the IL-1beta-induced increase in caspase-3 activity was abrogated by the p38 inhibitor, SB203580. SB 203580 268-276 interleukin 1 beta Rattus norvegicus 184-192 12052849-11 2002 Losartan prevented the rise in BP and SNS activity, as well as the decrease in IL-1beta and nNOS mRNA abundance caused by phenol. Phenol 122-128 interleukin 1 beta Rattus norvegicus 79-87 12052849-7 2002 The intrarenal injection of phenol raised BP, as well as central and renal SNS activity, but reduced the abundance of IL-1beta and neuronal NOS (nNOS) mRNA in the PH, PVN, and LC. Phenol 28-34 interleukin 1 beta Rattus norvegicus 118-126 12052849-12 2002 These studies have demonstrated that the antihypertensive action of losartan in the phenol renal injury model is largely mediated by inhibition of central and peripheral SNS activity and suggest that activation of IL-1beta and nNOS, 2 important modulators of central SNS activity, mediates the inhibitory action of losartan on SNS activity. Losartan 68-76 interleukin 1 beta Rattus norvegicus 214-222 12052849-9 2002 Losartan also caused a significant (P<0.01) and dose-dependent rise in IL-1beta and nNOS-mRNA gene expression in the PH, PVN, and LC of phenol-injected rats. Losartan 0-8 interleukin 1 beta Rattus norvegicus 74-82 12052849-9 2002 Losartan also caused a significant (P<0.01) and dose-dependent rise in IL-1beta and nNOS-mRNA gene expression in the PH, PVN, and LC of phenol-injected rats. Phenol 139-145 interleukin 1 beta Rattus norvegicus 74-82 12052849-10 2002 In conclusion, these studies have shown that the intrarenal injection of phenol causes a rise in central and renal SNS activity and a decrease in IL-1beta and nNOS-mRNA in the PH, PVN, and LC. Phenol 73-79 interleukin 1 beta Rattus norvegicus 146-154 12028436-0 2002 15-Deoxy-Delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells. 14-prostaglandin j2 17-36 interleukin 1 beta Rattus norvegicus 46-54 12052849-11 2002 Losartan prevented the rise in BP and SNS activity, as well as the decrease in IL-1beta and nNOS mRNA abundance caused by phenol. Losartan 0-8 interleukin 1 beta Rattus norvegicus 79-87 12107686-9 2002 Furthermore, treatment of rats with tyrphostin AG 126 significantly reduced the production of peroxynitrite and of pro-inflammatory cytokines TNF-alpha and IL-1beta. Tyrphostins 36-46 interleukin 1 beta Rattus norvegicus 156-164 12021578-5 2002 In the early-post-MI group, quinapril improved cardiac hemodynamics, improved ventricular remodeling, and prevented the increase in the expression of several cardiac cytokines (interleukin-1beta and -6) and reduced the cardiac expression of other cytokines (tumor necrosis factor-alpha and interleukin-5). Quinapril 28-37 interleukin 1 beta Rattus norvegicus 177-201 12028436-10 2002 RESULTS: 15D-PGJ2 significantly suppressed IL-1beta-induced COX-2 expression and PGE2 production, but thiazolidinediones, synthetic PPARgamma ligands, did not affect COX-2 expression. 15-deoxyprostaglandin J2 9-17 interleukin 1 beta Rattus norvegicus 43-51 12120758-3 2002 The present study was to investigate the effect of a calcium antagonist amlodipine on nitrite, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) formation and iNOS induction both in lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma)-treated rat aortic smooth muscle cells (RASMC) and in a rat model of endotoxemia. Calcium 53-60 interleukin 1 beta Rattus norvegicus 139-156 12120758-3 2002 The present study was to investigate the effect of a calcium antagonist amlodipine on nitrite, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) formation and iNOS induction both in lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma)-treated rat aortic smooth muscle cells (RASMC) and in a rat model of endotoxemia. Amlodipine 72-82 interleukin 1 beta Rattus norvegicus 139-156 12120758-4 2002 Incubation with amlodipine (0.1 - 10 microM) for 24 h resulted in a significant and dose-dependent attenuation in medium nitrite, TNF-alpha and IL-1beta formation as well as iNOS protein expression in LPS/IFN-gamma-treated RASMC. Amlodipine 16-26 interleukin 1 beta Rattus norvegicus 144-152 12120758-6 2002 In the rat endotoxic model, the serum nitrite/nitrate, TNF-alpha and IL-1beta levels as well as iNOS protein expression of lungs were also suppressed by administration of amlodipine (50 microg/kg, i.v.). Amlodipine 171-181 interleukin 1 beta Rattus norvegicus 69-77 12120758-3 2002 The present study was to investigate the effect of a calcium antagonist amlodipine on nitrite, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) formation and iNOS induction both in lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma)-treated rat aortic smooth muscle cells (RASMC) and in a rat model of endotoxemia. Amlodipine 72-82 interleukin 1 beta Rattus norvegicus 158-166 12028436-13 2002 15d-PGJ2 inhibited the IL-1beta-induced increase in binding activities of nuclear proteins to consensus AP-1 site and AP-1-like site of COX-2 promoter but not of NF-kappaB. 15-deoxy-delta(12,14)-prostaglandin J2 0-8 interleukin 1 beta Rattus norvegicus 23-31 12028436-15 2002 CONCLUSIONS: These data suggest that 15d-PGJ2 inhibits IL-1beta-induced COX-2 expression, independent of PPARgamma activation, by suppression of ERK and JNK pathways and AP-1 activation in mesangial cells. 15-deoxy-delta(12,14)-prostaglandin J2 37-45 interleukin 1 beta Rattus norvegicus 55-63 11922921-8 2002 Furthermore, TKT inhibited both IL-1beta and TNF-alpha secretion induced by PMA and A23187, respectively. Calcimycin 84-90 interleukin 1 beta Rattus norvegicus 32-40 12096922-0 2002 Interleukin-1beta-induced nitric oxide production and inhibition of insulin secretion in rat islets of langerhans is dependent upon the nitric oxide synthase cofactor tetrahidrobiopterin. Nitric Oxide 26-38 interleukin 1 beta Rattus norvegicus 0-17 11959672-5 2002 PNT dose dependently attenuated, without ablating, the elevation in serum TNF-alpha and IL-1beta and raised liver and spleen IL-10. Pentostatin 0-3 interleukin 1 beta Rattus norvegicus 88-96 11950807-6 2002 RESULTS: Interleukin 1beta, interleukin 1 receptor II, tumour necrosis factor alpha, and monocyte inflammatory peptide 2 but not monocyte chemoattractant protein 1 mRNA were detected in the epithelium within hours of indomethacin injection. Indomethacin 217-229 interleukin 1 beta Rattus norvegicus 9-83 12175593-9 2002 Previously defeated rats responded to the high dose of LPS with a deficient corticosterone (CORT) response resulting in an aggravated interleukin-1beta (IL-1beta) response 4 h after LPS injection. Corticosterone 76-90 interleukin 1 beta Rattus norvegicus 134-151 12175593-9 2002 Previously defeated rats responded to the high dose of LPS with a deficient corticosterone (CORT) response resulting in an aggravated interleukin-1beta (IL-1beta) response 4 h after LPS injection. Corticosterone 92-96 interleukin 1 beta Rattus norvegicus 134-151 12175593-9 2002 Previously defeated rats responded to the high dose of LPS with a deficient corticosterone (CORT) response resulting in an aggravated interleukin-1beta (IL-1beta) response 4 h after LPS injection. Corticosterone 92-96 interleukin 1 beta Rattus norvegicus 153-161 12096922-0 2002 Interleukin-1beta-induced nitric oxide production and inhibition of insulin secretion in rat islets of langerhans is dependent upon the nitric oxide synthase cofactor tetrahidrobiopterin. tetrahidrobiopterin 167-186 interleukin 1 beta Rattus norvegicus 0-17 12096922-1 2002 Interleukin (IL)-1 beta-induced inhibition of glucose-stimulated insulin secretion in rat islets of Langerhans is mediated in part by nitric oxide (NO). Glucose 46-53 interleukin 1 beta Rattus norvegicus 0-23 12096922-1 2002 Interleukin (IL)-1 beta-induced inhibition of glucose-stimulated insulin secretion in rat islets of Langerhans is mediated in part by nitric oxide (NO). Nitric Oxide 134-146 interleukin 1 beta Rattus norvegicus 0-23 12096922-2 2002 The NO synthase cofactor 5,6,7,8-tetrahydrobiopterin (BH(4)) supports NO synthesis in many cell types and IL-1 beta-induced NO generation and inhibition of insulin secretion have been previously correlated with intracellular BH(4 )levels in rat insulinoma cells. sapropterin 25-52 interleukin 1 beta Rattus norvegicus 106-115 12096922-4 2002 IL-1 beta-induced NO generation by BRIN cells and islets was reduced by 2,4-diamino-6-hydroxypyrimidine (DAHP), an inhibitor of de novo BH(4) synthesis. 2,4-diaminohypoxanthine 72-103 interleukin 1 beta Rattus norvegicus 0-9 12096922-4 2002 IL-1 beta-induced NO generation by BRIN cells and islets was reduced by 2,4-diamino-6-hydroxypyrimidine (DAHP), an inhibitor of de novo BH(4) synthesis. 2,4-diaminohypoxanthine 105-109 interleukin 1 beta Rattus norvegicus 0-9 12096922-6 2002 DAHP reversed IL-1 beta-induced inhibition of islet insulin secretion, an effect prevented by sepiapterin. 2,4-diaminohypoxanthine 0-4 interleukin 1 beta Rattus norvegicus 14-23 12096922-6 2002 DAHP reversed IL-1 beta-induced inhibition of islet insulin secretion, an effect prevented by sepiapterin. sepiapterin 94-105 interleukin 1 beta Rattus norvegicus 14-23 11990391-9 2002 The increase in interleukin-1beta seen after 3 hours reperfusion was partly reversed by lexipafant. lexipafant 88-98 interleukin 1 beta Rattus norvegicus 16-33 11888511-3 2002 Mevinolin also appears to oppose the increased vascular reactivity to ET-1 induced by interleukin 1-beta and phospholipase A(2) suggesting that statins display some anti-inflammatory properties. Lovastatin 0-9 interleukin 1 beta Rattus norvegicus 86-104 11922745-2 2002 space reduced TNF-alpha and IL-1beta mRNA synthesis in the brain after laparotomy, resulting in a reduction of nitrogen excretion in the urine. Nitrogen 111-119 interleukin 1 beta Rattus norvegicus 28-36 11877316-4 2002 Pre-treatment with the PAF receptor antagonist WEB 2086 inhibited des-Arg(9)-BK-induced oedema in IL-1 beta-treated paws, while the LTB(4) receptor antagonist CP105696 had no effect. des-arg 66-73 interleukin 1 beta Rattus norvegicus 98-107 11877316-13 2002 Des-Arg(9)-BK alone had no effect in MPO activity but enhanced (by about 40%) the response induced by IL-1 beta, an effect prevented by the B(1) receptor antagonist des-Arg(9)-[Leu(8)]-BK. des-arg 0-7 interleukin 1 beta Rattus norvegicus 102-111 11877316-13 2002 Des-Arg(9)-BK alone had no effect in MPO activity but enhanced (by about 40%) the response induced by IL-1 beta, an effect prevented by the B(1) receptor antagonist des-Arg(9)-[Leu(8)]-BK. des-arg 165-172 interleukin 1 beta Rattus norvegicus 102-111 11877316-19 2002 Finally, IL-1 beta induced an increase of B(1) receptor mRNA levels in the rat paw, an effect which was prevented by fucoidin treatment. fucoidan 117-125 interleukin 1 beta Rattus norvegicus 9-18 11867071-1 2002 This study describes the infiltration and death of monocyte/macrophages and concomitant endoneurial expression of the pro-inflammatory cytokine interleukin-1beta (IL-1beta) and neurotrophin receptor p75 (p75NTR) in the sciatic nerve at the early phases of experimental diabetic neuropathy induced in Lewis rats by streptozotocin (STZ) intraperitoneal injection. Streptozocin 314-328 interleukin 1 beta Rattus norvegicus 144-161 11867071-1 2002 This study describes the infiltration and death of monocyte/macrophages and concomitant endoneurial expression of the pro-inflammatory cytokine interleukin-1beta (IL-1beta) and neurotrophin receptor p75 (p75NTR) in the sciatic nerve at the early phases of experimental diabetic neuropathy induced in Lewis rats by streptozotocin (STZ) intraperitoneal injection. Streptozocin 330-333 interleukin 1 beta Rattus norvegicus 144-161 11953449-2 2002 In the present study, we examined the involvement of two types of phospholipase A2 (PLA2) enzymes, which lie upstream of COX in the prostanoid-generating pathway, in the IL-1beta-induced release of SP from DRG cells. Prostaglandins 132-142 interleukin 1 beta Rattus norvegicus 170-178 11875313-0 2002 Downregulation of nitric oxide accumulation by cyclooxygenase-2 induction and thromboxane A2 production in interleukin-1beta-stimulated rat aortic smooth muscle cells. Nitric Oxide 18-30 interleukin 1 beta Rattus norvegicus 107-124 11875313-4 2002 METHODS AND RESULTS: We studied the interleukin-1beta (IL-1beta)-induced production of nitric oxide in rat VSMCs using the TXA2/PGH2 receptor antagonists, seratrodast and Bay-u3405, and an agonist, U-46619. Nitric Oxide 87-99 interleukin 1 beta Rattus norvegicus 36-53 11875313-4 2002 METHODS AND RESULTS: We studied the interleukin-1beta (IL-1beta)-induced production of nitric oxide in rat VSMCs using the TXA2/PGH2 receptor antagonists, seratrodast and Bay-u3405, and an agonist, U-46619. Nitric Oxide 87-99 interleukin 1 beta Rattus norvegicus 55-63 11875313-4 2002 METHODS AND RESULTS: We studied the interleukin-1beta (IL-1beta)-induced production of nitric oxide in rat VSMCs using the TXA2/PGH2 receptor antagonists, seratrodast and Bay-u3405, and an agonist, U-46619. ramatroban 171-180 interleukin 1 beta Rattus norvegicus 36-53 11875313-4 2002 METHODS AND RESULTS: We studied the interleukin-1beta (IL-1beta)-induced production of nitric oxide in rat VSMCs using the TXA2/PGH2 receptor antagonists, seratrodast and Bay-u3405, and an agonist, U-46619. ramatroban 171-180 interleukin 1 beta Rattus norvegicus 55-63 11875313-6 2002 IL-1beta increased nitrite formation in a time-dependent manner. Nitrites 19-26 interleukin 1 beta Rattus norvegicus 0-8 11875313-14 2002 CONCLUSIONS: These data suggest that the expression of iNOS and the production of nitric oxide are regulated by the TXA2/PGH2 receptor in IL-1beta-stimulated VSMCs. Nitric Oxide 82-94 interleukin 1 beta Rattus norvegicus 138-146 11875313-15 2002 The endogenous production of TXA2 by the induction of COX-2 from IL-1beta-stimulated VSMCs probably downregulated the production of nitric oxide in VSMCs. Nitric Oxide 132-144 interleukin 1 beta Rattus norvegicus 65-73 11932065-11 2002 In conclusion, our results support the suggestion that IL-1beta- and IL-8-induced persistent mechanical nociceptor hypersensitivity results from the endogenous release of eicosanoids and sympathetic amines, respectively. Eicosanoids 171-182 interleukin 1 beta Rattus norvegicus 55-63 11932065-11 2002 In conclusion, our results support the suggestion that IL-1beta- and IL-8-induced persistent mechanical nociceptor hypersensitivity results from the endogenous release of eicosanoids and sympathetic amines, respectively. Amines 199-205 interleukin 1 beta Rattus norvegicus 55-63 11895038-6 2002 The presence of PS-liposomes strongly reduced the release of pro-inflammatory molecules such as nitric oxide, interleukin-1beta, and tumor necrosis factor-alpha by LPS-activated microglia. Phosphatidylserines 16-18 interleukin 1 beta Rattus norvegicus 110-127 11939499-3 2002 The present study was undertaken to examine the effect of acute ethanol pretreatments (producing blood alcohol concentrations of 100+/-16 mg/dL, and 220+/-10 mg/dL, considered low and intoxicating doses, respectively) on interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) levels in discrete brain regions. Ethanol 64-71 interleukin 1 beta Rattus norvegicus 221-238 11894041-10 2002 RESULTS: Serum levels of aspartate transaminase, alanine transaminase, lactate dehydrogenase, TNF-alpha, and IL-1beta were significantly lower in the FR-treated group than in the control group, and liver tissue blood flow was significantly higher in the FR-treated group than in the control group. FR 167653 150-152 interleukin 1 beta Rattus norvegicus 109-117 11930237-7 2002 There were different changes in IL-1 beta level and gene expression after treatment with PLA(2) inhibitor chloroquine, cyclo-oxidase inhibitor indomethacin, or PAF receptor antagonist SR27417 respectively after injury. Chloroquine 106-117 interleukin 1 beta Rattus norvegicus 32-41 11930237-7 2002 There were different changes in IL-1 beta level and gene expression after treatment with PLA(2) inhibitor chloroquine, cyclo-oxidase inhibitor indomethacin, or PAF receptor antagonist SR27417 respectively after injury. Indomethacin 143-155 interleukin 1 beta Rattus norvegicus 32-41 11930237-7 2002 There were different changes in IL-1 beta level and gene expression after treatment with PLA(2) inhibitor chloroquine, cyclo-oxidase inhibitor indomethacin, or PAF receptor antagonist SR27417 respectively after injury. Foropafant 184-191 interleukin 1 beta Rattus norvegicus 32-41 11953449-5 2002 The IL-1beta-induced SP release was significantly inhibited by the sPLA2 inhibitor, thioetheramide phosphorylcholine (TEA-PC), and the cPLA2 inhibitor, arachidonyl trifluoromethyl ketone (AACOCF3 ). thioetheramide phosphorylcholine 84-116 interleukin 1 beta Rattus norvegicus 4-12 11953449-5 2002 The IL-1beta-induced SP release was significantly inhibited by the sPLA2 inhibitor, thioetheramide phosphorylcholine (TEA-PC), and the cPLA2 inhibitor, arachidonyl trifluoromethyl ketone (AACOCF3 ). tea-pc 118-124 interleukin 1 beta Rattus norvegicus 4-12 11741883-2 2002 We have demonstrated previously that oxidative stress induced by benzenetriol-mediated superoxide production increases interleukin-1beta-induced iNOS protein synthesis, steady state iNOS mRNA expression, NO production, iNOS gene transcription, and trans-activation of the iNOS promoter in primary cultures of rat hepatocytes. benzenetriol 65-77 interleukin 1 beta Rattus norvegicus 119-136 11741883-2 2002 We have demonstrated previously that oxidative stress induced by benzenetriol-mediated superoxide production increases interleukin-1beta-induced iNOS protein synthesis, steady state iNOS mRNA expression, NO production, iNOS gene transcription, and trans-activation of the iNOS promoter in primary cultures of rat hepatocytes. Superoxides 87-97 interleukin 1 beta Rattus norvegicus 119-136 11953449-5 2002 The IL-1beta-induced SP release was significantly inhibited by the sPLA2 inhibitor, thioetheramide phosphorylcholine (TEA-PC), and the cPLA2 inhibitor, arachidonyl trifluoromethyl ketone (AACOCF3 ). arachidonyltrifluoromethane 152-186 interleukin 1 beta Rattus norvegicus 4-12 11953449-5 2002 The IL-1beta-induced SP release was significantly inhibited by the sPLA2 inhibitor, thioetheramide phosphorylcholine (TEA-PC), and the cPLA2 inhibitor, arachidonyl trifluoromethyl ketone (AACOCF3 ). arachidonyltrifluoromethane 188-195 interleukin 1 beta Rattus norvegicus 4-12 11953449-7 2002 These observations suggested that two types of PLA2, sPLA2 -IIA and cPLA2, were involved in the IL-1beta-induced release of SP from DRG cells, and that the functional cross-talk between the two enzymes might help to control their activity in the prostanoid-generating system in DRG cells. Prostaglandins 246-256 interleukin 1 beta Rattus norvegicus 96-104 11992649-2 2002 Injection of carrageenan into the pleural cavity of rats elicited an acute inflammatory response characterized by: fluid accumulation in the pleural cavity which contained a large number of polymorphonuclear neutrophils (PMNs) as well as an infiltration of PMNs in lung tissues and subsequent lipid peroxidation, and increased production of prostaglandin E(2) (PGE(2)), tumor necrosis factor alpha (TNFalpha), and interleukin-1beta. Carrageenan 13-24 interleukin 1 beta Rattus norvegicus 414-431 12423426-9 2002 Treatments of oesophagitis rats with rutin and harmaline inhibited IL-1beta production in the oesophagus in comparison with untreated rats, but TNF-alpha production was not affected by rutin and harmaline. Rutin 37-42 interleukin 1 beta Rattus norvegicus 67-75 11835309-1 2002 Interleukin (IL)-1beta mediates diverse forms of neurodegeneration and exacerbates cell death induced by striatal injection of the excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) in the rat brain. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 143-200 interleukin 1 beta Rattus norvegicus 0-22 11835309-1 2002 Interleukin (IL)-1beta mediates diverse forms of neurodegeneration and exacerbates cell death induced by striatal injection of the excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) in the rat brain. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 202-206 interleukin 1 beta Rattus norvegicus 0-22 12423426-9 2002 Treatments of oesophagitis rats with rutin and harmaline inhibited IL-1beta production in the oesophagus in comparison with untreated rats, but TNF-alpha production was not affected by rutin and harmaline. Harmaline 47-56 interleukin 1 beta Rattus norvegicus 67-75 12423426-12 2002 The results of this study suggest that rutin and harmaline may have beneficial protective effects against reflux oesophagitis by the inhibition of gastric acid secretion, oxidative stress, inflammatory cytokine production (i.e. IL-1beta), and intracellular calcium mobilization in PMNs in rats. Rutin 39-44 interleukin 1 beta Rattus norvegicus 228-236 12423426-12 2002 The results of this study suggest that rutin and harmaline may have beneficial protective effects against reflux oesophagitis by the inhibition of gastric acid secretion, oxidative stress, inflammatory cytokine production (i.e. IL-1beta), and intracellular calcium mobilization in PMNs in rats. Harmaline 49-58 interleukin 1 beta Rattus norvegicus 228-236 11813247-0 2002 Zaprinast, an inhibitor of cGMP-selective phosphodiesterases, enhances the secretion of TNF-alpha and IL-1beta and the expression of iNOS and MHC class II molecules in rat microglial cells. zaprinast 0-9 interleukin 1 beta Rattus norvegicus 102-110 11861327-4 2002 IL-1beta caused a significant reduction in albuterol-mediated relaxation to protect against MCh-induced bronchoconstriction. Albuterol 43-52 interleukin 1 beta Rattus norvegicus 0-8 11861327-5 2002 Dexamethasone attenuated the IL-1beta-induced impaired relaxation while alone had no effect when compared to rats treated identically with saline. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 29-37 11861327-7 2002 The density of beta(2)-adrenoceptors was significantly reduced in lung membranes harvested from IL-1beta-treated rats, which was associated with impaired isoproterenol- and forskolin-stimulated cyclic AMP accumulation and adenylyl cyclase (AC) activity ex vivo. Isoproterenol 154-167 interleukin 1 beta Rattus norvegicus 96-104 11861327-7 2002 The density of beta(2)-adrenoceptors was significantly reduced in lung membranes harvested from IL-1beta-treated rats, which was associated with impaired isoproterenol- and forskolin-stimulated cyclic AMP accumulation and adenylyl cyclase (AC) activity ex vivo. Colforsin 173-182 interleukin 1 beta Rattus norvegicus 96-104 11861327-7 2002 The density of beta(2)-adrenoceptors was significantly reduced in lung membranes harvested from IL-1beta-treated rats, which was associated with impaired isoproterenol- and forskolin-stimulated cyclic AMP accumulation and adenylyl cyclase (AC) activity ex vivo. Cyclic AMP 194-204 interleukin 1 beta Rattus norvegicus 96-104 11861327-8 2002 Dexamethasone did not prevent IL-1beta-induced down-regulation of beta(2)-adrenoceptors but completely blocked IL-1beta-induced impairment of cyclic AMP accumulation and AC activity stimulated by isoproterenol and forskolin. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 111-119 11861327-8 2002 Dexamethasone did not prevent IL-1beta-induced down-regulation of beta(2)-adrenoceptors but completely blocked IL-1beta-induced impairment of cyclic AMP accumulation and AC activity stimulated by isoproterenol and forskolin. Isoproterenol 196-209 interleukin 1 beta Rattus norvegicus 111-119 11861327-8 2002 Dexamethasone did not prevent IL-1beta-induced down-regulation of beta(2)-adrenoceptors but completely blocked IL-1beta-induced impairment of cyclic AMP accumulation and AC activity stimulated by isoproterenol and forskolin. Colforsin 214-223 interleukin 1 beta Rattus norvegicus 111-119 11861327-12 2002 The activity of cytosolic GRK and the expression of GRK2 and GRK5 were elevated in the lung of IL-1beta-treated rats, which were completely abolished by dexamethasone. Dexamethasone 153-166 interleukin 1 beta Rattus norvegicus 95-103 11882601-3 2002 Moreover, in 2 rat models of neurogenic hypertension, one caused by intrarenal injection of phenol and the other by 5/6 nephrectomy, we observed that losartan, an Ang II type 1 receptor blocker, inhibits SNS activity and increases the abundance of IL-1beta and the neuronal isoform of nitric oxide synthase (nNOS) in the posterior hypothalamic nuclei (PH), paraventricular nuclei (PVN), and locus ceruleus (LC). Losartan 150-158 interleukin 1 beta Rattus norvegicus 248-256 11882601-9 2002 Pretreatment with losartan (10 microg/kg body wt dissolved in 10 microL of aCSF) given ICV 20 minutes before Ang II abolished the effects of Ang II on BP, RSNA, and NE secretion from the PH and IL-1beta and nNOS mRNA. Losartan 18-26 interleukin 1 beta Rattus norvegicus 194-202 11791017-4 2002 Fluvastatin but not pravastatin enhanced apoptosis in interleukin-1beta-stimulated VSMCs. Fluvastatin 0-11 interleukin 1 beta Rattus norvegicus 54-71 11791017-8 2002 Furthermore, fluvastatin-induced apoptosis was inhibited by YVAD-FMK (a caspase-1/interleukin-1beta-converting enzyme-like protease inhibitor) and DEVD-FMK (a caspase-3/CPP32 inhibitor), indicating involvement of an important segment in the apoptosis signaling pathway. Fluvastatin 13-24 interleukin 1 beta Rattus norvegicus 82-99 11791017-8 2002 Furthermore, fluvastatin-induced apoptosis was inhibited by YVAD-FMK (a caspase-1/interleukin-1beta-converting enzyme-like protease inhibitor) and DEVD-FMK (a caspase-3/CPP32 inhibitor), indicating involvement of an important segment in the apoptosis signaling pathway. tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone 60-68 interleukin 1 beta Rattus norvegicus 82-99 11847504-4 2002 The depression of contractility by IL-1beta and TNF-alpha was prevented by administration of a nonselective nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME) or an inhibitor of inducible nitric oxide synthase, L-canavanine. NG-Nitroarginine Methyl Ester 141-175 interleukin 1 beta Rattus norvegicus 35-43 11847504-4 2002 The depression of contractility by IL-1beta and TNF-alpha was prevented by administration of a nonselective nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME) or an inhibitor of inducible nitric oxide synthase, L-canavanine. NG-Nitroarginine Methyl Ester 177-183 interleukin 1 beta Rattus norvegicus 35-43 11847504-4 2002 The depression of contractility by IL-1beta and TNF-alpha was prevented by administration of a nonselective nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME) or an inhibitor of inducible nitric oxide synthase, L-canavanine. Canavanine 237-249 interleukin 1 beta Rattus norvegicus 35-43 11847504-6 2002 These results support current thinking that the depression of myocardial function by IL-1beta and TNF-alpha is mediated, at least in part, by an intracardiac increase in inducible nitric oxide synthase, and that in contrast to L-NAME, the decline in coronary conductance seen in cytokine-treated is not prevented by L-canavanine hearts. Canavanine 316-328 interleukin 1 beta Rattus norvegicus 85-93 11813247-4 2002 In primary cultures of mixed astrocytes and microglial cells, zaprinast (0.1 mM), an inhibitor of cGMP-selective phosphodiesterases, enhanced the basal and LPS (1.0 microg/ml)-induced secretion of TNF-alpha and IL-1beta. zaprinast 62-71 interleukin 1 beta Rattus norvegicus 211-219 11813247-5 2002 Zaprinast also enhanced NO production induced by LPS or IFN-gamma (100 U/ml), and in microglial cell cultures, but not in astrocyte cultures, zaprinast enhanced the basal and the IFN-gamma-induced production of the cytokines, TNF-alpha and IL-1beta, and of NO. zaprinast 142-151 interleukin 1 beta Rattus norvegicus 240-248 11813247-6 2002 This upregulation by zaprinast was partially inhibited by KT5823 (1.0 microM), an inhibitor of protein kinase G. The LPS-induced production of TNF-alpha, IL-1beta, and NO was inhibited by ODQ (50 microM), an inhibitor of soluble guanylyl cyclase, and by KT5823. zaprinast 21-30 interleukin 1 beta Rattus norvegicus 154-162 11813247-6 2002 This upregulation by zaprinast was partially inhibited by KT5823 (1.0 microM), an inhibitor of protein kinase G. The LPS-induced production of TNF-alpha, IL-1beta, and NO was inhibited by ODQ (50 microM), an inhibitor of soluble guanylyl cyclase, and by KT5823. KT 5823 58-64 interleukin 1 beta Rattus norvegicus 154-162 11813247-9 2002 Summarizing, zaprinast, which is associated with cGMP/protein kinase G signaling, may augment central immune/inflammatory reactions, possibly via the increased production of TNF-alpha and IL-1beta by activated microglial cells. zaprinast 13-22 interleukin 1 beta Rattus norvegicus 188-196 11821653-9 2002 EtOH consumption attenuated fever induced by LPS or IL-1beta administered ip during the light phase and significantly reduced hypothalamic production of IL-1beta. Ethanol 0-4 interleukin 1 beta Rattus norvegicus 52-60 11801247-1 2002 We recently reported that glucosamine reversed the decrease in proteoglycan synthesis and in UDP-glucuronosyltransferase I mRNA expression induced by interleukin-1 beta (IL-1 beta) [Arthritis Rheum. Glucosamine 26-37 interleukin 1 beta Rattus norvegicus 150-168 11801247-1 2002 We recently reported that glucosamine reversed the decrease in proteoglycan synthesis and in UDP-glucuronosyltransferase I mRNA expression induced by interleukin-1 beta (IL-1 beta) [Arthritis Rheum. Glucosamine 26-37 interleukin 1 beta Rattus norvegicus 170-179 11801247-4 2002 In order to better understand its mechanism of action, we determined if glucosamine could prevent the binding of IL-1 beta to its cellular receptors or could interfere with its signaling pathway at a post-receptor level. Glucosamine 72-83 interleukin 1 beta Rattus norvegicus 113-122 11801247-5 2002 Addition of glucosamine to rat chondrocytes treated with IL-1 beta or with ROS decreased the activation of the nuclear factor kappa B, but not the activator protein-1. Glucosamine 12-23 interleukin 1 beta Rattus norvegicus 57-66 11801247-6 2002 After treatment with IL-1 beta, glucosamine increased the expression of mRNA encoding the type II IL-1 beta receptor. Glucosamine 32-43 interleukin 1 beta Rattus norvegicus 21-30 11801247-6 2002 After treatment with IL-1 beta, glucosamine increased the expression of mRNA encoding the type II IL-1 beta receptor. Glucosamine 32-43 interleukin 1 beta Rattus norvegicus 98-107 11801247-7 2002 These results emphasize the potential role of two regulating proteins of the IL-1 beta signaling pathway that could account for the beneficial effect of glucosamine in osteoarthritis. Glucosamine 153-164 interleukin 1 beta Rattus norvegicus 77-86 11853230-1 2002 Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. Nitric Oxide 10-22 interleukin 1 beta Rattus norvegicus 128-145 11853230-1 2002 Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. Nitric Oxide 10-22 interleukin 1 beta Rattus norvegicus 147-155 11853230-1 2002 Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. Prostaglandins 211-225 interleukin 1 beta Rattus norvegicus 128-145 11853230-1 2002 Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. Prostaglandins 211-225 interleukin 1 beta Rattus norvegicus 147-155 11853230-1 2002 Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. Prostaglandins 227-230 interleukin 1 beta Rattus norvegicus 128-145 11853230-1 2002 Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. Prostaglandins 227-230 interleukin 1 beta Rattus norvegicus 147-155 11853230-1 2002 Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. Epoprostenol 240-244 interleukin 1 beta Rattus norvegicus 128-145 11853230-1 2002 Inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 are expressed in vascular smooth muscle cells stimulated with interleukin-1beta (IL-1beta), resulting in the production of nitric oxide (NO) and prostaglandins (PGs) such as PGI2. Epoprostenol 240-244 interleukin 1 beta Rattus norvegicus 147-155 12044018-4 2002 Using in situ hybridization technique, it was found that in the MCAO group the expression of IL-1beta mRNA was significantly increased at 2h, 6h, 12h after reperfusion in cerebral ischemic cortex compared with normal group. Deuterium 138-140 interleukin 1 beta Rattus norvegicus 93-101 12044018-4 2002 Using in situ hybridization technique, it was found that in the MCAO group the expression of IL-1beta mRNA was significantly increased at 2h, 6h, 12h after reperfusion in cerebral ischemic cortex compared with normal group. 6H 142-144 interleukin 1 beta Rattus norvegicus 93-101 12044018-4 2002 Using in situ hybridization technique, it was found that in the MCAO group the expression of IL-1beta mRNA was significantly increased at 2h, 6h, 12h after reperfusion in cerebral ischemic cortex compared with normal group. 12-hydroxydodecanoic acid 146-149 interleukin 1 beta Rattus norvegicus 93-101 11786214-6 2002 By comparison, the effect of IL-1beta-induced neutrophil accumulation was significantly potentiated by co-stimulation of the ipsilateral saphenous nerve; an effect prevented by an NK(1) receptor antagonist (SR140333, 480 nmol/kg, i.v.). SR 140333 207-215 interleukin 1 beta Rattus norvegicus 29-37 11821653-0 2002 Alcohol consumption attenuates febrile responses to lipopolysaccharide and interleukin-1 beta in male rats. Alcohols 0-7 interleukin 1 beta Rattus norvegicus 75-93 11821653-9 2002 EtOH consumption attenuated fever induced by LPS or IL-1beta administered ip during the light phase and significantly reduced hypothalamic production of IL-1beta. Ethanol 0-4 interleukin 1 beta Rattus norvegicus 153-161 11821653-11 2002 Central administration of IL-1beta produced a normal febrile response in chronic-EtOH rats. Ethanol 81-85 interleukin 1 beta Rattus norvegicus 26-34 11821653-12 2002 CONCLUSIONS: The attenuated LPS- and IL-1beta-induced febrile responses in EtOH-consuming rats and the corresponding deficit in hypothalamic production of IL-1beta suggest that alcohol may impair IL-1beta-mediated neuroimmune communication. Ethanol 75-79 interleukin 1 beta Rattus norvegicus 37-45 11821653-12 2002 CONCLUSIONS: The attenuated LPS- and IL-1beta-induced febrile responses in EtOH-consuming rats and the corresponding deficit in hypothalamic production of IL-1beta suggest that alcohol may impair IL-1beta-mediated neuroimmune communication. Alcohols 177-184 interleukin 1 beta Rattus norvegicus 37-45 11821653-12 2002 CONCLUSIONS: The attenuated LPS- and IL-1beta-induced febrile responses in EtOH-consuming rats and the corresponding deficit in hypothalamic production of IL-1beta suggest that alcohol may impair IL-1beta-mediated neuroimmune communication. Alcohols 177-184 interleukin 1 beta Rattus norvegicus 155-163 11821653-12 2002 CONCLUSIONS: The attenuated LPS- and IL-1beta-induced febrile responses in EtOH-consuming rats and the corresponding deficit in hypothalamic production of IL-1beta suggest that alcohol may impair IL-1beta-mediated neuroimmune communication. Alcohols 177-184 interleukin 1 beta Rattus norvegicus 155-163 12082283-4 2002 Using L-NMMA (1 mM), as a NO synthase inhibitor, and CuDips (10 microM), as a SOD mimetic, we provide evidence that the inhibitory potency of IL-1beta on proteoglycan synthesis and its stimulating effect on COX-2 activity depend both on NO and O2-* production. omega-N-Methylarginine 6-12 interleukin 1 beta Rattus norvegicus 142-150 11755929-4 2002 Both IL-1beta and TNF-alpha stimulated NF-kappaB activity, iNOS mRNA and protein expression with massive nitrite/nitrate (NOx) production in rat VSMCs. Nitrites 105-112 interleukin 1 beta Rattus norvegicus 5-13 11755929-4 2002 Both IL-1beta and TNF-alpha stimulated NF-kappaB activity, iNOS mRNA and protein expression with massive nitrite/nitrate (NOx) production in rat VSMCs. Nitrates 113-120 interleukin 1 beta Rattus norvegicus 5-13 11755929-4 2002 Both IL-1beta and TNF-alpha stimulated NF-kappaB activity, iNOS mRNA and protein expression with massive nitrite/nitrate (NOx) production in rat VSMCs. nicotine 1-N-oxide 122-125 interleukin 1 beta Rattus norvegicus 5-13 12082283-4 2002 Using L-NMMA (1 mM), as a NO synthase inhibitor, and CuDips (10 microM), as a SOD mimetic, we provide evidence that the inhibitory potency of IL-1beta on proteoglycan synthesis and its stimulating effect on COX-2 activity depend both on NO and O2-* production. Superoxides 244-246 interleukin 1 beta Rattus norvegicus 142-150 12085975-7 2002 Quinapril did however attenuate the MI-induced rise in cardiac cytokine expression (tumor necrosis factor-alpha [TNF-alpha], interleukin-1beta, -5 and -6). Quinapril 0-9 interleukin 1 beta Rattus norvegicus 125-153 12097830-0 2002 The anti-platelet agent, ticlopidine, upregulates interleukin-1-Beta-stimulated nitric oxide production in cultured rat vascular smooth muscle cells. Ticlopidine 25-36 interleukin 1 beta Rattus norvegicus 50-68 12640177-8 2002 HI induced an increase in mRNA expression for IL-1beta, TNF-alpha and TNF-beta, but there was no difference between the ipsi- and contralateral hemispheres. hi 0-2 interleukin 1 beta Rattus norvegicus 46-54 12097830-0 2002 The anti-platelet agent, ticlopidine, upregulates interleukin-1-Beta-stimulated nitric oxide production in cultured rat vascular smooth muscle cells. Nitric Oxide 80-92 interleukin 1 beta Rattus norvegicus 50-68 12097830-6 2002 RESULTS: Ticlopidine enhanced interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner. Ticlopidine 9-20 interleukin 1 beta Rattus norvegicus 30-47 12097830-6 2002 RESULTS: Ticlopidine enhanced interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner. Ticlopidine 9-20 interleukin 1 beta Rattus norvegicus 49-57 12097830-6 2002 RESULTS: Ticlopidine enhanced interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner. Nitrites 67-74 interleukin 1 beta Rattus norvegicus 30-47 12097830-6 2002 RESULTS: Ticlopidine enhanced interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner. Nitrites 67-74 interleukin 1 beta Rattus norvegicus 49-57 12097830-8 2002 IL-1beta alone stimulated both intracellular cAMP and cGMP contents, and the addition of ticlopidine further enhanced their contents. Cyclic AMP 45-49 interleukin 1 beta Rattus norvegicus 0-8 12097830-8 2002 IL-1beta alone stimulated both intracellular cAMP and cGMP contents, and the addition of ticlopidine further enhanced their contents. Cyclic GMP 54-58 interleukin 1 beta Rattus norvegicus 0-8 12097830-8 2002 IL-1beta alone stimulated both intracellular cAMP and cGMP contents, and the addition of ticlopidine further enhanced their contents. Ticlopidine 89-100 interleukin 1 beta Rattus norvegicus 0-8 12097830-9 2002 KT 5720, a selective inhibitor of protein kinase A, but not KT 5823, a selective inhibitor of protein kinase G, abolished the enhancement of IL-1beta-induced nitrite production by ticlopidine. Nitrites 158-165 interleukin 1 beta Rattus norvegicus 141-149 12097830-9 2002 KT 5720, a selective inhibitor of protein kinase A, but not KT 5823, a selective inhibitor of protein kinase G, abolished the enhancement of IL-1beta-induced nitrite production by ticlopidine. Ticlopidine 180-191 interleukin 1 beta Rattus norvegicus 141-149 12097830-10 2002 In addition, a phosphodiesterase inhibitor, isobutylmethylxanthine, enhanced IL-1beta and ticlopidine induced nitrite production. 1-Methyl-3-isobutylxanthine 44-66 interleukin 1 beta Rattus norvegicus 77-85 12097830-11 2002 CONCLUSION: We concluded that ticlopidine enhanced the IL-1beta-induced NO production via cAMP and subsequent activation of protein kinase A in cultured rat VSMC. Ticlopidine 30-41 interleukin 1 beta Rattus norvegicus 55-63 12097830-11 2002 CONCLUSION: We concluded that ticlopidine enhanced the IL-1beta-induced NO production via cAMP and subsequent activation of protein kinase A in cultured rat VSMC. Cyclic AMP 90-94 interleukin 1 beta Rattus norvegicus 55-63 12097830-11 2002 CONCLUSION: We concluded that ticlopidine enhanced the IL-1beta-induced NO production via cAMP and subsequent activation of protein kinase A in cultured rat VSMC. vsmc 157-161 interleukin 1 beta Rattus norvegicus 55-63 11900276-0 2002 Effect of aldose reductase inhibition on interleukin-1beta-induced nitric oxide (NO) synthesis in vascular tissue. Nitric Oxide 67-79 interleukin 1 beta Rattus norvegicus 41-58 11852909-6 2002 RESULTS: Indomethacin or dipyrone reduced LPS, IL-1beta, IL-6 or TNF-alpha induced fever and CRH release from rat hypothalamus. Indomethacin 9-21 interleukin 1 beta Rattus norvegicus 47-55 11852909-6 2002 RESULTS: Indomethacin or dipyrone reduced LPS, IL-1beta, IL-6 or TNF-alpha induced fever and CRH release from rat hypothalamus. Dipyrone 25-33 interleukin 1 beta Rattus norvegicus 47-55 11852909-8 2002 Only indomethacin inhibited fever induced by AA or IL-1beta, plus AA. Indomethacin 5-17 interleukin 1 beta Rattus norvegicus 51-59 11900276-8 2002 Interleukin-1beta stimulated the 24 hr nitric oxide production and WAY 121509 decreased it under both low and high glucose culture conditions. Nitric Oxide 39-51 interleukin 1 beta Rattus norvegicus 0-17 11900276-10 2002 Nitric oxide production in response to interleukin-1beta was greater at all time points when compared to the incubation in media without interleukin-1beta. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 39-56 11900276-10 2002 Nitric oxide production in response to interleukin-1beta was greater at all time points when compared to the incubation in media without interleukin-1beta. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 137-154 11900276-12 2002 Interleukin-1beta stimulated a greater increase in nitric oxide production from aortic rings when incubated in high glucose when compared to normal glucose. Nitric Oxide 51-63 interleukin 1 beta Rattus norvegicus 0-17 11900276-12 2002 Interleukin-1beta stimulated a greater increase in nitric oxide production from aortic rings when incubated in high glucose when compared to normal glucose. Glucose 116-123 interleukin 1 beta Rattus norvegicus 0-17 11900276-12 2002 Interleukin-1beta stimulated a greater increase in nitric oxide production from aortic rings when incubated in high glucose when compared to normal glucose. Glucose 148-155 interleukin 1 beta Rattus norvegicus 0-17 11900276-14 2002 We conclude that high glucose enhances the interleukin-1beta-induced nitric oxide synthesis and the cytokine-induced nitric oxide production was inhibited by aldose reductase inhibition. Glucose 22-29 interleukin 1 beta Rattus norvegicus 43-60 11900276-14 2002 We conclude that high glucose enhances the interleukin-1beta-induced nitric oxide synthesis and the cytokine-induced nitric oxide production was inhibited by aldose reductase inhibition. Nitric Oxide 69-81 interleukin 1 beta Rattus norvegicus 43-60 11743230-4 2002 Carvedilol reduced cardiac expression of interleukin-1beta but did not prevent cardiac fetal gene re-expression or modify cardiac oxidative stress. Carvedilol 0-10 interleukin 1 beta Rattus norvegicus 41-58 12162412-3 2002 RESULTS: The intravenous administration of MP (30 mg/kg body weight) significantly reduced the increase in pancreas web weight, volume of ascites, hematocrit, serum amylase activity, concentrations of IL-1beta and IL-6, histological edema, and necrosis observed in CDL pancreatitis. Methylprednisolone 43-45 interleukin 1 beta Rattus norvegicus 201-209 11709410-4 2001 IBAT SND did not change after IL-1 beta administration but was significantly increased during acute mild hypothermia, which was induced 60 min after IL-1 beta treatment. ibat 0-4 interleukin 1 beta Rattus norvegicus 149-158 12013149-0 2002 Effect of fentanyl on TNF-alpha and IL-1beta levels during global ischemia/reperfusion in rats. Fentanyl 10-18 interleukin 1 beta Rattus norvegicus 36-44 12013149-3 2002 The goal of this study was to evaluate the effect of fentanyl infusion on levels of the proinflammatory cytokines, tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta, during global cerebral ischemia/reperfusion in rats using the intracerebral microdialysis technique. Fentanyl 53-61 interleukin 1 beta Rattus norvegicus 153-175 12013149-12 2002 However, in both cases of fentanyl infusion, TNF-alpha and IL-1beta showed no increase compared with the control value. Fentanyl 26-34 interleukin 1 beta Rattus norvegicus 59-67 12013149-13 2002 Fentanyl inhibited an increase of the proinflammatory cytokines, TNF-alpha and IL-1beta levels, during global cerebral ischemia/reperfusion in rats. Fentanyl 0-8 interleukin 1 beta Rattus norvegicus 79-87 12584407-4 2002 RESULTS: Our observations in these mixed cultures indicated that addition of IL-1beta exaggerated NMDA and glutamate-evoked hippocampal neuron death. Glutamic Acid 107-116 interleukin 1 beta Rattus norvegicus 77-85 11786081-7 2002 Since MnTBAP, a superoxide dismutase mimetic, had no effects on the amplification of mRNA levels, we suggest that H2O2 is the candidate reactive oxygen species (ROS) responsible for the potentiation of IL-1beta-triggered tPA and PAI-1 expression. Hydrogen Peroxide 114-118 interleukin 1 beta Rattus norvegicus 202-210 11786081-7 2002 Since MnTBAP, a superoxide dismutase mimetic, had no effects on the amplification of mRNA levels, we suggest that H2O2 is the candidate reactive oxygen species (ROS) responsible for the potentiation of IL-1beta-triggered tPA and PAI-1 expression. Reactive Oxygen Species 136-159 interleukin 1 beta Rattus norvegicus 202-210 11786081-7 2002 Since MnTBAP, a superoxide dismutase mimetic, had no effects on the amplification of mRNA levels, we suggest that H2O2 is the candidate reactive oxygen species (ROS) responsible for the potentiation of IL-1beta-triggered tPA and PAI-1 expression. Reactive Oxygen Species 161-164 interleukin 1 beta Rattus norvegicus 202-210 12584407-3 2002 METHOD: In the present studies, we examined the role of interleukin-1beta (IL-1beta) in NMDA-related and microglia-induced excitotoxicity in cocultures of mixed neurons and microglia. N-Methylaspartate 88-92 interleukin 1 beta Rattus norvegicus 56-73 12584407-3 2002 METHOD: In the present studies, we examined the role of interleukin-1beta (IL-1beta) in NMDA-related and microglia-induced excitotoxicity in cocultures of mixed neurons and microglia. N-Methylaspartate 88-92 interleukin 1 beta Rattus norvegicus 75-83 12584407-4 2002 RESULTS: Our observations in these mixed cultures indicated that addition of IL-1beta exaggerated NMDA and glutamate-evoked hippocampal neuron death. N-Methylaspartate 98-102 interleukin 1 beta Rattus norvegicus 77-85 11749811-5 2001 PA 10 mg/kg reduced MDA content in inflamed paws, inhibited beta-NAG and NOS activity, and lowered the content of NO, IL-1beta, TNFalpha, and PGE2 in exudate from edema paws of rats induced by carrageenan. Proanthocyanidins 0-2 interleukin 1 beta Rattus norvegicus 118-126 11709410-7 2001 Increases in IBAT SND during sustained (120 min) hypothermia were significantly higher in IL-1 beta-treated rats compared with saline-treated rats, whereas renal SND responses to sustained hypothermia did not differ among groups. ibat 13-17 interleukin 1 beta Rattus norvegicus 90-99 11709410-9 2001 These data suggest that IL-1 beta alters IBAT SND responses to acute and sustained hypothermia. ibat 41-45 interleukin 1 beta Rattus norvegicus 24-33 11860476-4 2001 The evidence presented supports the view that this is secondary to the stress-induced increase in IL-1beta concentration, as IL-1beta increased activity of superoxide dismutase and increased reactive oxygen species accumulation in hippocampus in vitro. Reactive Oxygen Species 191-214 interleukin 1 beta Rattus norvegicus 98-106 11860476-4 2001 The evidence presented supports the view that this is secondary to the stress-induced increase in IL-1beta concentration, as IL-1beta increased activity of superoxide dismutase and increased reactive oxygen species accumulation in hippocampus in vitro. Reactive Oxygen Species 191-214 interleukin 1 beta Rattus norvegicus 125-133 11860476-5 2001 We report that the inhibitory effect of stress on LTP is mimicked by H2O2, which increases reactive oxygen species accumulation, and by IL-1beta, the effect of which is overcome by the antioxidant, phenylarsine oxide. oxophenylarsine 198-216 interleukin 1 beta Rattus norvegicus 136-144 11714876-15 2001 Moreover, colonic cytokine levels (TNF-alpha and IL-1beta) were significantly reduced in CAPE-treated rats. caffeic acid phenethyl ester 89-93 interleukin 1 beta Rattus norvegicus 49-57 11910991-0 2001 Vasoactive intestinal peptide is involved in the inhibitory effect of interleukin-1 beta on the jejunal contractile response induced by acetylcholine. Acetylcholine 136-149 interleukin 1 beta Rattus norvegicus 70-88 11910991-1 2001 UNLABELLED: Although previous studies have shown that interleukin-1 beta (IL-1 beta) decreases acetylcholine (ACh)-induced intestinal contraction by an action on the enteric nervous system, the neuromediator(s) involved are still unknown. Acetylcholine 95-108 interleukin 1 beta Rattus norvegicus 54-72 11910991-1 2001 UNLABELLED: Although previous studies have shown that interleukin-1 beta (IL-1 beta) decreases acetylcholine (ACh)-induced intestinal contraction by an action on the enteric nervous system, the neuromediator(s) involved are still unknown. Acetylcholine 95-108 interleukin 1 beta Rattus norvegicus 74-83 11910991-1 2001 UNLABELLED: Although previous studies have shown that interleukin-1 beta (IL-1 beta) decreases acetylcholine (ACh)-induced intestinal contraction by an action on the enteric nervous system, the neuromediator(s) involved are still unknown. Acetylcholine 110-113 interleukin 1 beta Rattus norvegicus 54-72 11910991-1 2001 UNLABELLED: Although previous studies have shown that interleukin-1 beta (IL-1 beta) decreases acetylcholine (ACh)-induced intestinal contraction by an action on the enteric nervous system, the neuromediator(s) involved are still unknown. Acetylcholine 110-113 interleukin 1 beta Rattus norvegicus 74-83 11742864-3 2001 Either PD98059 or U0126, selective inhibitors of ERK activation, did not influence IL-1beta-induced early activation but effectively reduced the prolonged activation of NF-kappaB and significantly reduced IL-1beta induction of iNOS. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 7-14 interleukin 1 beta Rattus norvegicus 205-213 11742864-3 2001 Either PD98059 or U0126, selective inhibitors of ERK activation, did not influence IL-1beta-induced early activation but effectively reduced the prolonged activation of NF-kappaB and significantly reduced IL-1beta induction of iNOS. U 0126 18-23 interleukin 1 beta Rattus norvegicus 205-213 11742864-4 2001 Transfection with antisense, but not sense, phosphorothioate-modified oligodeoxynucleotides directed toward ERK also reduced IL-1beta-induced prolonged NF-kappaB activation and iNOS expression. Parathion 44-60 interleukin 1 beta Rattus norvegicus 125-133 11742864-4 2001 Transfection with antisense, but not sense, phosphorothioate-modified oligodeoxynucleotides directed toward ERK also reduced IL-1beta-induced prolonged NF-kappaB activation and iNOS expression. Oligodeoxyribonucleotides 70-91 interleukin 1 beta Rattus norvegicus 125-133 11735269-6 2001 RESULTS: Expressions of TNF-alpha and IL-1 beta in the remnant liver were significantly inhibited in the FR group compared to the saline group. Sodium Chloride 130-136 interleukin 1 beta Rattus norvegicus 38-47 11571275-6 2001 Treatment with the p38 MAPK inhibitor, SB202190, decreased interleukin-1beta stimulated MAPKAP-K2 activity, GIIa PLA(2) mRNA expression, GIIa PLA(2) protein synthesis, and the release of extracellular PLA(2) activity. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 39-47 interleukin 1 beta Rattus norvegicus 59-76 24383773-1 2001 Abstract The effects of FR167653, a dual inhibitor of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha production, on the development of adjuvant arthritis were investigated in rats. FR 167653 24-32 interleukin 1 beta Rattus norvegicus 54-76 11746392-0 2001 Differential effects of the nonsteroidal antiinflammatory drug flurbiprofen and its nitric oxide-releasing derivative, nitroflurbiprofen, on prostaglandin E(2), interleukin-1beta, and nitric oxide synthesis by activated microglia. Flurbiprofen 63-75 interleukin 1 beta Rattus norvegicus 161-178 11698145-4 2001 When rats were pre-treated with Escherichia coli lipopolisaccharide (LPS), an enhancement of cardiovascular response elicited by IL-1 beta and TNF alpha was found. lipopolisaccharide 49-67 interleukin 1 beta Rattus norvegicus 129-138 11698145-4 2001 When rats were pre-treated with Escherichia coli lipopolisaccharide (LPS), an enhancement of cardiovascular response elicited by IL-1 beta and TNF alpha was found. lps 69-72 interleukin 1 beta Rattus norvegicus 129-138 11696360-0 2001 Interleukin-1beta stimulates cyclic GMP efflux in brain astrocytes. Cyclic GMP 29-39 interleukin 1 beta Rattus norvegicus 0-17 11733865-0 2001 Interleukin-1 beta inhibits proinsulin conversion in rat beta-cells via a nitric oxide-dependent pathway. Nitric Oxide 74-86 interleukin 1 beta Rattus norvegicus 0-18 11696360-4 2001 In cells treated with bacterial endotoxin a larger NO-dependent cGMP accumulation occurs only intracellularly, however a significant cGMP egression is observed when cells are co-treated with interleukin-1beta. Cyclic GMP 133-137 interleukin 1 beta Rattus norvegicus 191-208 11696360-5 2001 The non-selective anion transport inhibitors probenecid and verapamil block cGMP efflux, indicating that interleukin-1beta stimulates a cGMP transporter. Probenecid 45-55 interleukin 1 beta Rattus norvegicus 105-122 11696360-5 2001 The non-selective anion transport inhibitors probenecid and verapamil block cGMP efflux, indicating that interleukin-1beta stimulates a cGMP transporter. Verapamil 60-69 interleukin 1 beta Rattus norvegicus 105-122 11696360-5 2001 The non-selective anion transport inhibitors probenecid and verapamil block cGMP efflux, indicating that interleukin-1beta stimulates a cGMP transporter. Cyclic GMP 76-80 interleukin 1 beta Rattus norvegicus 105-122 11729502-0 2001 Lovastatin increases nitric oxide synthesis in IL-1 beta-stimulated smooth muscle cells. Lovastatin 0-10 interleukin 1 beta Rattus norvegicus 47-56 11729502-0 2001 Lovastatin increases nitric oxide synthesis in IL-1 beta-stimulated smooth muscle cells. Nitric Oxide 21-33 interleukin 1 beta Rattus norvegicus 47-56 11729502-6 2001 RESULTS: Lovastatin (10(-5) mol/L) significantly increased interleukin-1 beta (IL-1 beta, 10 ng/mL)-induced nitrite accumulation in a time (0-24 hours)-dependent manner. Lovastatin 9-19 interleukin 1 beta Rattus norvegicus 59-77 11729502-6 2001 RESULTS: Lovastatin (10(-5) mol/L) significantly increased interleukin-1 beta (IL-1 beta, 10 ng/mL)-induced nitrite accumulation in a time (0-24 hours)-dependent manner. Lovastatin 9-19 interleukin 1 beta Rattus norvegicus 79-88 11729502-6 2001 RESULTS: Lovastatin (10(-5) mol/L) significantly increased interleukin-1 beta (IL-1 beta, 10 ng/mL)-induced nitrite accumulation in a time (0-24 hours)-dependent manner. Nitrites 108-115 interleukin 1 beta Rattus norvegicus 59-77 11729502-6 2001 RESULTS: Lovastatin (10(-5) mol/L) significantly increased interleukin-1 beta (IL-1 beta, 10 ng/mL)-induced nitrite accumulation in a time (0-24 hours)-dependent manner. Nitrites 108-115 interleukin 1 beta Rattus norvegicus 79-88 11729502-8 2001 Furthermore, inhibition of Rho by C3 exoenzyme mimicked the increase in IL-1 beta-induced nitrite accumulation induced by lovastatin in the vascular smooth muscle cells. Nitrites 90-97 interleukin 1 beta Rattus norvegicus 72-81 11729502-8 2001 Furthermore, inhibition of Rho by C3 exoenzyme mimicked the increase in IL-1 beta-induced nitrite accumulation induced by lovastatin in the vascular smooth muscle cells. Lovastatin 122-132 interleukin 1 beta Rattus norvegicus 72-81 11729502-9 2001 CONCLUSION: These results demonstrate that lovastatin up-regulates NO formation in rat vascular smooth muscle cells stimulated by IL-1 beta, and the effect may be associated with the inhibition of Rho activity. Lovastatin 43-53 interleukin 1 beta Rattus norvegicus 130-139 11711044-3 2001 The cholinesterase inhibitor physostigmine at a dose of 3.2 microg/side and D-cycloserine (1.0 and 10 microg/side), which is a partial agonist acting at the glycine binding site of the NMDA receptor/channel complex, reduced the increase in working memory errors induced by 100 ng/side interleukin-1beta. Glycine 157-164 interleukin 1 beta Rattus norvegicus 285-302 11679969-8 2001 This IL-1 beta-induced decrease was likely caused by degradation via the proteasome, because it was prevented by the addition of the proteasome inhibitor, MG132. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 155-160 interleukin 1 beta Rattus norvegicus 5-14 11733865-7 2001 The suppressive effects of IL-1 beta on proinsulin synthesis and conversion were prevented by addition of NMA. Nitroarginine 106-109 interleukin 1 beta Rattus norvegicus 27-36 11699081-9 2001 A single dose of GLN significantly attenuated the release of TNF-alpha at 2 h (P < 0.005) and IL-1 beta at 4 h (P < 0.0001). Glutamine 17-20 interleukin 1 beta Rattus norvegicus 97-106 11760899-7 2001 Dexamethasone inhibited interleukin-1beta induced, NF-kappaB driven gene transcription only in IEC-6 and not in Caco-2 cells. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 24-41 11578770-3 2001 IL-1 beta, which can act as a mitogen for astrocytes, also elicits the expression and secretion of multiple factors and paracrine "second messengers" such as other cytokines, nerve growth factor, prostaglandins and nitric oxide that may in turn modulate neuronal and glial responses to injury. Prostaglandins 196-210 interleukin 1 beta Rattus norvegicus 0-9 11578770-3 2001 IL-1 beta, which can act as a mitogen for astrocytes, also elicits the expression and secretion of multiple factors and paracrine "second messengers" such as other cytokines, nerve growth factor, prostaglandins and nitric oxide that may in turn modulate neuronal and glial responses to injury. Nitric Oxide 215-227 interleukin 1 beta Rattus norvegicus 0-9 11694623-6 2001 Administration of long-chain fatty acids significantly increased the GRO/CINC-1 and IL-6 secretion into culture media, and this secretion was markedly increased (P < 0.05) in the presence of IL-1beta or TGF-beta. long-chain fatty acids 18-40 interleukin 1 beta Rattus norvegicus 194-202 11694623-8 2001 Furthermore, treatment with long-chain fatty acids significantly enhanced the GRO/CINC-1 and IL-6 expression that was induced by IL-1beta or TGF-beta. long-chain fatty acids 28-50 interleukin 1 beta Rattus norvegicus 129-137 11593036-3 2001 Using a doxycycline-inducible SOCS-3 expression system in the rat beta-cell line INS-1, we demonstrate that the toxic effect of both IL-1beta or IFN-gamma at concentrations that reduced the viability by 50% over 3 days, was fully preventable when SOCS-3 expression was turned on in the cells. Doxycycline 8-19 interleukin 1 beta Rattus norvegicus 133-141 11698071-5 2001 Caerulein administration induced acute edematous pancreatitis manifested by 41% decrease in DNA synthesis, 53% inhibition of pancreatic blood flow, a significant increase in plasma amylase and lipase activity, plasma interleukin-1beta and interleukin-6 concentration, as well as, the development of the histological signs of pancreatic damage (edema, leukocyte infiltration, and vacuolization). Ceruletide 0-9 interleukin 1 beta Rattus norvegicus 217-234 11595215-0 2001 Effects of serotonin synthesis blockade on interleukin-1 beta action in the brain of rats. Serotonin 11-20 interleukin 1 beta Rattus norvegicus 43-61 11595215-3 2001 Pre-treatment with p-chlorphenylalanine, an inhibitor of serotonin synthesis, blocked the IL-1beta-induced decrease in food intake and loss of body weight, but failed to alter the temperature increase and the decrease in communicative activity. Fenclonine 19-39 interleukin 1 beta Rattus norvegicus 90-98 11595215-3 2001 Pre-treatment with p-chlorphenylalanine, an inhibitor of serotonin synthesis, blocked the IL-1beta-induced decrease in food intake and loss of body weight, but failed to alter the temperature increase and the decrease in communicative activity. Serotonin 57-66 interleukin 1 beta Rattus norvegicus 90-98 11593036-6 2001 In addition we show that SOCS-3 prevention of IL-1beta-induced toxicity is accompanied by inhibited transcription of the inducible nitric oxide synthase (iNOS) by 80%, resulting in 60% decreased formation of the toxic nitric oxide (NO). Nitric Oxide 131-143 interleukin 1 beta Rattus norvegicus 46-54 11767459-4 2001 The opposite effects of two doses of IL-1 beta were observed also in a test with saccharine. Saccharin 81-91 interleukin 1 beta Rattus norvegicus 37-46 11606330-11 2001 Corticosterone did not affect the resting plasma corticotrophin (ACTH) concentration but suppressed the hypersecretion of ACTH induced by IL-1beta (i.p. Corticosterone 0-14 interleukin 1 beta Rattus norvegicus 138-146 11686836-3 2001 FR167653 (C24H18FN5O2-H2SO4-H2O) is a newly synthesized organic compound with a potent inhibitory effect on IL-1beta and TNF-alpha production. c24h18fn5o2-h2so4-h2o 10-31 interleukin 1 beta Rattus norvegicus 108-116 11686836-9 2001 Colonic mucosal TNF-alpha and IL-1beta levels of rats treated with FR167653 showed significant decrease in a dose-dependent fashion compared with the control group. FR 167653 67-75 interleukin 1 beta Rattus norvegicus 30-38 11833422-4 2001 Injection of anti-rat TNF alpha and IL-1 beta antibodies, alpha-MSH and KPV prevented Rt of aldosterone binding activity from decrease in kidney cytosol of rats with heavy-degree scald. Aldosterone 92-103 interleukin 1 beta Rattus norvegicus 36-45 11833422-5 2001 These findings suggest that aldosterone binding activity may be down-regulated in heavy-degree scalded rats, but it may be reversed by injection of anti-rat TNF alpha and IL-1 beta antibodies, alpha-MSH and KPV. Aldosterone 28-39 interleukin 1 beta Rattus norvegicus 171-180 11606330-11 2001 Corticosterone did not affect the resting plasma corticotrophin (ACTH) concentration but suppressed the hypersecretion of ACTH induced by IL-1beta (i.p. acth 122-126 interleukin 1 beta Rattus norvegicus 138-146 11606330-23 2001 They also provide novel evidence that the positive influence of the steroids on GH secretion evident within this timeframe is effected centrally via an annexin 1-dependent mechanism which is antagonized by IL-1beta. Steroids 68-76 interleukin 1 beta Rattus norvegicus 206-214 11686836-3 2001 FR167653 (C24H18FN5O2-H2SO4-H2O) is a newly synthesized organic compound with a potent inhibitory effect on IL-1beta and TNF-alpha production. FR 167653 0-8 interleukin 1 beta Rattus norvegicus 108-116 11589995-3 2001 Our recent data suggest that the pro-inflammatory cytokine interleukin-1beta (IL-1beta) acts at specific sites (e.g., the striatum) in the rat brain to cause distant cortical injury, when co-administered with the potent excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (S-AMPA). alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate 232-284 interleukin 1 beta Rattus norvegicus 59-76 11819851-6 2001 CCK-8 significantly inhibited the LPS-induced increase in serum TNF-alpha IL-1beta and IL-6. Sincalide 0-5 interleukin 1 beta Rattus norvegicus 74-82 11819851-9 2001 In the heart, CCK-8 significantly inhibited LPS-induced increase of TNF-alpha (864 +/- 123 ng.L(-1) in CCK-8+LPS group vs 1599 +/- 227 ng.L(-1) in LPS group, P < 0.01), and IL-1beta (282 +/- 93 ng.L(-1) in CCK-8+LPS group vs 621 +/- 145ng.L(-1) in LPS group, P < 0.01). Sincalide 14-19 interleukin 1 beta Rattus norvegicus 176-184 11578593-9 2001 Application of pyrrolidine dithiocarbamate, an inhibitor of nuclear factor-kB (NF-kappaB), prior to LPS stimulation not only prevented up-regulation of NF-kappaB gene expression, but also completely blocked up-regulation of pro-inflammatory cytokine genes (TNF-alpha and interleukin-1beta) and two chemokine genes: CXC chemokine LIX and CC chemokine MIP-3 alpha. pyrrolidine dithiocarbamic acid 15-42 interleukin 1 beta Rattus norvegicus 271-288 11525800-0 2001 Intracerebroventricular interleukin-1beta impairs clearance of tumor cells from the lungs: role of brain prostaglandins. Prostaglandins 105-119 interleukin 1 beta Rattus norvegicus 24-41 11525800-7 2001 Central administration of the prostaglandin antagonist, diclofenac (250 ug), but not ibuprofen, completely blocked the effect of IL-1beta on lung clearance of tumor cells. Prostaglandins 30-43 interleukin 1 beta Rattus norvegicus 129-137 11525800-7 2001 Central administration of the prostaglandin antagonist, diclofenac (250 ug), but not ibuprofen, completely blocked the effect of IL-1beta on lung clearance of tumor cells. Diclofenac 56-66 interleukin 1 beta Rattus norvegicus 129-137 11585587-0 2001 Hypothalamic 11,12-epoxyeicosatrienoic acid attenuates fever induced by central interleukin-1beta in the rat. 11,12-epoxy-5,8,14-eicosatrienoic acid 13-43 interleukin 1 beta Rattus norvegicus 80-97 11594790-3 2001 Our results indicate that thymic stimulation (performed by means of interleukin 1beta) induces substantial changes in the fresh weight of the whole thymus, as well as in the thymic microenvironment, thymic nerve fibres, CNF, neuropeptide Y (NPY)-like positive nerve fibres and total amount of both proteins and norepinephrine in rat thymic tissue homogenates. Norepinephrine 311-325 interleukin 1 beta Rattus norvegicus 68-85 11589995-3 2001 Our recent data suggest that the pro-inflammatory cytokine interleukin-1beta (IL-1beta) acts at specific sites (e.g., the striatum) in the rat brain to cause distant cortical injury, when co-administered with the potent excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (S-AMPA). alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate 232-284 interleukin 1 beta Rattus norvegicus 78-86 11589995-3 2001 Our recent data suggest that the pro-inflammatory cytokine interleukin-1beta (IL-1beta) acts at specific sites (e.g., the striatum) in the rat brain to cause distant cortical injury, when co-administered with the potent excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (S-AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 286-292 interleukin 1 beta Rattus norvegicus 59-76 11589995-3 2001 Our recent data suggest that the pro-inflammatory cytokine interleukin-1beta (IL-1beta) acts at specific sites (e.g., the striatum) in the rat brain to cause distant cortical injury, when co-administered with the potent excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (S-AMPA). alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 286-292 interleukin 1 beta Rattus norvegicus 78-86 11489265-8 2001 Immunohistochemical and ELISA studies demonstrated upregulated expression of IL-1beta in retinas that had undergone NMDA injection. N-Methylaspartate 116-120 interleukin 1 beta Rattus norvegicus 77-85 11596859-11 2001 Plasma interleukin-1beta was significantly reduced after administration of omeprazole, ranitidine, or histamine, however, the effect of histamine was less pronounced. Omeprazole 75-85 interleukin 1 beta Rattus norvegicus 7-24 11596859-11 2001 Plasma interleukin-1beta was significantly reduced after administration of omeprazole, ranitidine, or histamine, however, the effect of histamine was less pronounced. Ranitidine 87-97 interleukin 1 beta Rattus norvegicus 7-24 11596859-11 2001 Plasma interleukin-1beta was significantly reduced after administration of omeprazole, ranitidine, or histamine, however, the effect of histamine was less pronounced. Histamine 102-111 interleukin 1 beta Rattus norvegicus 7-24 11514054-2 2001 Rat 17K IL-1alpha and IL-1beta, 32K IL-1alpha precursor (32proIL-1alpha) and a 24K splice variant (24proIL-1alpha) stimulated testosterone production by Leydig cells from 40- but not 80-day-old rats. Testosterone 126-138 interleukin 1 beta Rattus norvegicus 22-30 11509539-3 2001 Recently, we demonstrated that nitric oxide (NO) inhibits interleukin-1 beta (IL-1 beta)-stimulated MMP-9 induction in rat aortic VSM cells. Nitric Oxide 31-43 interleukin 1 beta Rattus norvegicus 58-76 11509539-3 2001 Recently, we demonstrated that nitric oxide (NO) inhibits interleukin-1 beta (IL-1 beta)-stimulated MMP-9 induction in rat aortic VSM cells. Nitric Oxide 31-43 interleukin 1 beta Rattus norvegicus 78-87 11531023-7 2001 (2) Inhibition of NO synthesis with L-NAME in rats subjected to HI/R also enhanced systemic inflammatory response as assessed by the increase in the number of circulating leukocytes and levels of plasma tumor necrosis factor-alpha (TNFalpha) and interleukin 1-beta (IL-1beta). NG-Nitroarginine Methyl Ester 36-42 interleukin 1 beta Rattus norvegicus 246-264 11531023-7 2001 (2) Inhibition of NO synthesis with L-NAME in rats subjected to HI/R also enhanced systemic inflammatory response as assessed by the increase in the number of circulating leukocytes and levels of plasma tumor necrosis factor-alpha (TNFalpha) and interleukin 1-beta (IL-1beta). NG-Nitroarginine Methyl Ester 36-42 interleukin 1 beta Rattus norvegicus 266-274 11531023-9 2001 (4) Pulmonary alveolar macrophages isolated from rats subjected to HI/R + L-NAME produced higher levels of TNFalpha and IL-1beta in the supernatant of culture medium than that of rats subjected to HI/R alone. NG-Nitroarginine Methyl Ester 74-80 interleukin 1 beta Rattus norvegicus 120-128 11531023-12 2001 The increase in TNFalpha and IL-1beta production by alveolar macrophages may, in part, account for L-NAME-induced enhancement of acute lung injury. NG-Nitroarginine Methyl Ester 99-105 interleukin 1 beta Rattus norvegicus 29-37 11498262-0 2001 Chronic morphine potentiates the inflammatory response by disrupting interleukin-1beta modulation of the hypothalamic-pituitary-adrenal axis. Morphine 8-16 interleukin 1 beta Rattus norvegicus 69-86 11498262-2 2001 In this study, chronic morphine was shown to suppress IL-1beta-induction of corticotropin releasing factor (CRF) mRNA and plasma corticosterone levels. Morphine 23-31 interleukin 1 beta Rattus norvegicus 54-62 11498262-2 2001 In this study, chronic morphine was shown to suppress IL-1beta-induction of corticotropin releasing factor (CRF) mRNA and plasma corticosterone levels. Corticosterone 129-143 interleukin 1 beta Rattus norvegicus 54-62 11498262-4 2001 Chronic morphine potentiated the LEA response to either IL-1beta or FMLP alone, and greatly enhanced LEA in response to combined IL-1beta and FMLP. Morphine 8-16 interleukin 1 beta Rattus norvegicus 56-64 11498262-4 2001 Chronic morphine potentiated the LEA response to either IL-1beta or FMLP alone, and greatly enhanced LEA in response to combined IL-1beta and FMLP. Morphine 8-16 interleukin 1 beta Rattus norvegicus 129-137 11498262-5 2001 Thus, it appears that chronic morphine exposure may promote a potentially damaging inflammatory reaction by disrupting the balance between IL-1beta-mediated local inflammation and the anti-inflammatory effects of the HPA axis. Morphine 30-38 interleukin 1 beta Rattus norvegicus 139-147 11478844-6 2001 The stimulation of PKC-beta(I) translocation by PTH, TNF-alpha or IL-1 beta was inhibited by LY379196. 5,21 - 12,17-dimetheneo-18H-dibenzo(i,o)pyrrolo(3,4-1)(1,8)diazacyclohexandecine-18,10(19H)dione,8((dimethylamino)methyl)-6,7,8,9,10,11-hexahydro,monomethanesulfonate 93-101 interleukin 1 beta Rattus norvegicus 66-75 11489265-0 2001 Dual effects of interleukin-1beta on N-methyl-D-aspartate-induced retinal neuronal death in rat eyes. N-Methylaspartate 37-57 interleukin 1 beta Rattus norvegicus 16-33 11489265-1 2001 In this study we determine if interleukin-1beta (IL-1beta) modulates N-methyl-D-aspartate (NMDA)-induced retinal damage. N-Methylaspartate 69-89 interleukin 1 beta Rattus norvegicus 30-47 11489265-1 2001 In this study we determine if interleukin-1beta (IL-1beta) modulates N-methyl-D-aspartate (NMDA)-induced retinal damage. N-Methylaspartate 69-89 interleukin 1 beta Rattus norvegicus 49-57 11489265-1 2001 In this study we determine if interleukin-1beta (IL-1beta) modulates N-methyl-D-aspartate (NMDA)-induced retinal damage. N-Methylaspartate 91-95 interleukin 1 beta Rattus norvegicus 30-47 11489265-1 2001 In this study we determine if interleukin-1beta (IL-1beta) modulates N-methyl-D-aspartate (NMDA)-induced retinal damage. N-Methylaspartate 91-95 interleukin 1 beta Rattus norvegicus 49-57 11489265-10 2001 Pretreatment with IL-1beta induced a significant protective effect on NMDA-induced retinal damage. N-Methylaspartate 70-74 interleukin 1 beta Rattus norvegicus 18-26 11489265-11 2001 Our studies suggest that IL-1beta induces neuronal cell death directly, as shown by the protective effects of IL-1ra, but has a protective effect on NMDA-induced retinal damage indirectly after an incubation time of at least 2 days. N-Methylaspartate 149-153 interleukin 1 beta Rattus norvegicus 25-33 11506125-0 2001 Halothane but not isoflurane attenuates interleukin 1beta-induced nitric oxide synthase in vascular smooth muscle. Halothane 0-9 interleukin 1 beta Rattus norvegicus 40-57 11506125-3 2001 The aim of the current study was to examine the effect of halothane on the IL-1beta-evoked induction of NOS in vascular smooth muscle. Halothane 58-67 interleukin 1 beta Rattus norvegicus 75-83 11506125-10 2001 Halothane at 3.0% significantly inhibited the increase in cyclic guanosine monophosphate content induced by IL-1beta. Halothane 0-9 interleukin 1 beta Rattus norvegicus 108-116 11506125-5 2001 The effects of halothane (1.0-3.0%) or isoflurane (3.0%) on IL-1beta (20 ng/ml)-induced inhibition of the contractile responses to KCl (30 mM) and phenylephrine (10(-9)-10(-5) M) were studied. Halothane 15-24 interleukin 1 beta Rattus norvegicus 60-68 11506125-10 2001 Halothane at 3.0% significantly inhibited the increase in cyclic guanosine monophosphate content induced by IL-1beta. Cyclic GMP 58-88 interleukin 1 beta Rattus norvegicus 108-116 11506125-12 2001 IL-1beta-induced expression of iNOS and iNOS mRNA in the rat aorta were inhibited significantly by halothane. Halothane 99-108 interleukin 1 beta Rattus norvegicus 0-8 11506125-5 2001 The effects of halothane (1.0-3.0%) or isoflurane (3.0%) on IL-1beta (20 ng/ml)-induced inhibition of the contractile responses to KCl (30 mM) and phenylephrine (10(-9)-10(-5) M) were studied. Isoflurane 39-49 interleukin 1 beta Rattus norvegicus 60-68 11506125-13 2001 CONCLUSION: The current study demonstrated that halothane but not isoflurane inhibits IL-1beta-stimulated hyporesponsiveness to vasoconstrictive agents in vascular smooth muscle and that this inhibitory effect of halothane involves the inhibition of iNOS mRNA expression. Halothane 48-57 interleukin 1 beta Rattus norvegicus 86-94 11506125-5 2001 The effects of halothane (1.0-3.0%) or isoflurane (3.0%) on IL-1beta (20 ng/ml)-induced inhibition of the contractile responses to KCl (30 mM) and phenylephrine (10(-9)-10(-5) M) were studied. Potassium Chloride 131-134 interleukin 1 beta Rattus norvegicus 60-68 11506125-5 2001 The effects of halothane (1.0-3.0%) or isoflurane (3.0%) on IL-1beta (20 ng/ml)-induced inhibition of the contractile responses to KCl (30 mM) and phenylephrine (10(-9)-10(-5) M) were studied. Phenylephrine 147-160 interleukin 1 beta Rattus norvegicus 60-68 11506125-9 2001 The cyclic guanosine monophosphate content of the vascular smooth muscle increased significantly after a 5-h exposure to IL-1beta. Cyclic GMP 4-34 interleukin 1 beta Rattus norvegicus 121-129 11556886-5 2001 Blockade of the IL-1beta-converting enzyme (ICE) by Tyr-Val-Ala-Asp-aldehyde (YVAD-CHO) decreased the levels of mature IL-1beta but had no effect on pro-IL-1beta. tyrosyl-valyl-alanyl-aspartal 52-76 interleukin 1 beta Rattus norvegicus 16-24 11556886-5 2001 Blockade of the IL-1beta-converting enzyme (ICE) by Tyr-Val-Ala-Asp-aldehyde (YVAD-CHO) decreased the levels of mature IL-1beta but had no effect on pro-IL-1beta. tyrosyl-valyl-alanyl-aspartal 52-76 interleukin 1 beta Rattus norvegicus 119-127 11556886-5 2001 Blockade of the IL-1beta-converting enzyme (ICE) by Tyr-Val-Ala-Asp-aldehyde (YVAD-CHO) decreased the levels of mature IL-1beta but had no effect on pro-IL-1beta. tyrosyl-valyl-alanyl-aspartal 78-86 interleukin 1 beta Rattus norvegicus 16-24 11556886-5 2001 Blockade of the IL-1beta-converting enzyme (ICE) by Tyr-Val-Ala-Asp-aldehyde (YVAD-CHO) decreased the levels of mature IL-1beta but had no effect on pro-IL-1beta. tyrosyl-valyl-alanyl-aspartal 78-86 interleukin 1 beta Rattus norvegicus 119-127 11508863-4 2001 Tissue cytokine mRNA expression (TNF-alpha, IL-1beta, IL-10) was decreased in the lung and the liver but not in the mesenteric lymph node or ileum, in the glycine-fed group. Glycine 155-162 interleukin 1 beta Rattus norvegicus 44-52 11454939-6 2001 The current work shows ethanol also suppresses cytokine-induced iNOS expression and reduces interleukin-1beta and tumor necrosis factor-alpha potency without affecting interferon-gamma potency. Ethanol 23-30 interleukin 1 beta Rattus norvegicus 92-141 11672585-1 2001 Daunorubicin (0.1-1 microM) concentration-dependently inhibited prostacyclin production induced by interleukin-1beta (IL-1beta, 2.5 ng/ml) in cultured aortic smooth muscle cells isolated from rats. Daunorubicin 0-12 interleukin 1 beta Rattus norvegicus 99-116 11672585-1 2001 Daunorubicin (0.1-1 microM) concentration-dependently inhibited prostacyclin production induced by interleukin-1beta (IL-1beta, 2.5 ng/ml) in cultured aortic smooth muscle cells isolated from rats. Daunorubicin 0-12 interleukin 1 beta Rattus norvegicus 118-126 11672585-1 2001 Daunorubicin (0.1-1 microM) concentration-dependently inhibited prostacyclin production induced by interleukin-1beta (IL-1beta, 2.5 ng/ml) in cultured aortic smooth muscle cells isolated from rats. Epoprostenol 64-76 interleukin 1 beta Rattus norvegicus 99-116 11672585-1 2001 Daunorubicin (0.1-1 microM) concentration-dependently inhibited prostacyclin production induced by interleukin-1beta (IL-1beta, 2.5 ng/ml) in cultured aortic smooth muscle cells isolated from rats. Epoprostenol 64-76 interleukin 1 beta Rattus norvegicus 118-126 11672585-2 2001 IL-1beta stimulation caused activation of nuclear factor-kappaB (NF-kappaB) and expression of cyclooxygenase-2 (COX-2) mRNA and protein, which were inhibited by daunorubicin. Daunorubicin 161-173 interleukin 1 beta Rattus norvegicus 0-8 11672585-5 2001 Daunorubicin also inhibited nitric oxide (NO) production induced by IL-1beta. Daunorubicin 0-12 interleukin 1 beta Rattus norvegicus 68-76 11672585-5 2001 Daunorubicin also inhibited nitric oxide (NO) production induced by IL-1beta. Nitric Oxide 28-40 interleukin 1 beta Rattus norvegicus 68-76 11702679-10 2001 17-beta estradiol at 3 x 10(-8)-10(-6) mol/L counteracts the increase of VCAM-1 in VECs induced by interleukin-1 beta. Estradiol 0-17 interleukin 1 beta Rattus norvegicus 99-117 11580140-5 2001 Both pentoxifylline and dexamethasone inhibited TNFalpha and IL-1beta production, albeit to a different extent, iNOS induction and, as a result thereof, NO production. Pentoxifylline 5-19 interleukin 1 beta Rattus norvegicus 61-69 11580140-5 2001 Both pentoxifylline and dexamethasone inhibited TNFalpha and IL-1beta production, albeit to a different extent, iNOS induction and, as a result thereof, NO production. Dexamethasone 24-37 interleukin 1 beta Rattus norvegicus 61-69 11469895-7 2001 RESULTS: Cyclic AMP dose dependently decreased NO synthesis in response to a combination of proinflammatory cytokines or interleukin-1beta (IL-1beta) alone. Cyclic AMP 9-19 interleukin 1 beta Rattus norvegicus 121-138 11469895-7 2001 RESULTS: Cyclic AMP dose dependently decreased NO synthesis in response to a combination of proinflammatory cytokines or interleukin-1beta (IL-1beta) alone. Cyclic AMP 9-19 interleukin 1 beta Rattus norvegicus 140-148 11702679-8 2001 17-beta estradiol at the contents of 3 x 10(-8)-10(-6) mol/L all counteracted the increase in expression rate of VCAM-1 induced by interleukin-1 beta (15.4% +/- 1.42%, 12.4% +/- 0.34%, 8.7% +/- 0.27%, P < 0.01). Estradiol 0-17 interleukin 1 beta Rattus norvegicus 131-149 11454665-6 2001 In vitro the cytokine combination; interleukin-1beta, tumor necrosis factor-alpha and interferon-gamma inhibited glucose-stimulated insulin secretion from isolated rat islets of Langerhans and decreased RIN-5F cell viability. Glucose 113-120 interleukin 1 beta Rattus norvegicus 35-81 11274144-1 2001 Transforming growth factor (TGF)-alpha and interleukin (IL)-1beta are responsible for the healing of gastric lesions through, in part, prostaglandin (PG) generation. Prostaglandins 135-148 interleukin 1 beta Rattus norvegicus 43-65 11582860-3 2001 Vitamin E supplementation, which resulted in increased colonic vitamin E levels, reduced colonic weight and damage score, prevented lipid peroxidation and diarrhea, reduced interleukin-1 beta levels and preserved glutathione reductase activity and total glutathione levels. Vitamin E 0-9 interleukin 1 beta Rattus norvegicus 173-191 11450697-4 2001 In contrast to these findings, the stimulatory effects of PTH, TNF-alpha, and IL-1beta on the IL-6 promoter expression were enhanced by staurosporine. Staurosporine 136-149 interleukin 1 beta Rattus norvegicus 78-86 11444504-5 2001 The lipophilic statins fluvastatin and lovastatin significantly increased interleukin-1beta-induced nitrite production by cardiac myocytes, whereas hydrophilic pravastatin did not. Fluvastatin 23-34 interleukin 1 beta Rattus norvegicus 74-91 11444504-5 2001 The lipophilic statins fluvastatin and lovastatin significantly increased interleukin-1beta-induced nitrite production by cardiac myocytes, whereas hydrophilic pravastatin did not. Lovastatin 39-49 interleukin 1 beta Rattus norvegicus 74-91 11444504-5 2001 The lipophilic statins fluvastatin and lovastatin significantly increased interleukin-1beta-induced nitrite production by cardiac myocytes, whereas hydrophilic pravastatin did not. Nitrites 100-107 interleukin 1 beta Rattus norvegicus 74-91 11444504-9 2001 Furthermore, both Rho inhibitor C3 exoenzyme and Rho kinase inhibitor Y-27632 significantly increased interleukin-1beta-induced nitrite accumulation in cardiac myocytes. Y 27632 70-77 interleukin 1 beta Rattus norvegicus 102-119 11444504-9 2001 Furthermore, both Rho inhibitor C3 exoenzyme and Rho kinase inhibitor Y-27632 significantly increased interleukin-1beta-induced nitrite accumulation in cardiac myocytes. Nitrites 128-135 interleukin 1 beta Rattus norvegicus 102-119 11436078-9 2001 Reverse transcriptase-polymerase chain reaction and Western blot analysis revealed that the addition of L-NMMA to IL-1beta-stimulated RA-SMCs led to significant increases in MMP-9 mRNA (n = 3, P <.01 for 1.0 mmol/L L-NMMA) and MMP-9 protein levels (n = 3, P <.05), respectively. N(G)-monomethylarginine acetate 218-224 interleukin 1 beta Rattus norvegicus 114-122 11484850-5 2001 The untreated rats, and groups receiving monotherapy with IFN-gamma or 25% BZL, had increased circulating interleukin (IL)-1beta and IL-2 levels, which were reduced in those given BZL plus IFN-gamma. benzonidazole 75-78 interleukin 1 beta Rattus norvegicus 106-128 11274144-1 2001 Transforming growth factor (TGF)-alpha and interleukin (IL)-1beta are responsible for the healing of gastric lesions through, in part, prostaglandin (PG) generation. Prostaglandins 150-152 interleukin 1 beta Rattus norvegicus 43-65 11274144-8 2001 Furthermore, despite an increase in cPLA(2) including its phosphorylated form (phosphoserine), -induced arachidonic acid liberation was impaired in the TGF-alpha/IL-1beta-stimulated cells, in which p11, a putative cPLA(2) inhibitory molecule, was also increased and co-immunoprecipitated with cPLA(2). cpla 36-40 interleukin 1 beta Rattus norvegicus 162-170 11274144-8 2001 Furthermore, despite an increase in cPLA(2) including its phosphorylated form (phosphoserine), -induced arachidonic acid liberation was impaired in the TGF-alpha/IL-1beta-stimulated cells, in which p11, a putative cPLA(2) inhibitory molecule, was also increased and co-immunoprecipitated with cPLA(2). Phosphoserine 79-92 interleukin 1 beta Rattus norvegicus 162-170 11274144-8 2001 Furthermore, despite an increase in cPLA(2) including its phosphorylated form (phosphoserine), -induced arachidonic acid liberation was impaired in the TGF-alpha/IL-1beta-stimulated cells, in which p11, a putative cPLA(2) inhibitory molecule, was also increased and co-immunoprecipitated with cPLA(2). Arachidonic Acid 104-120 interleukin 1 beta Rattus norvegicus 162-170 11274144-9 2001 These results suggest that synergistic stimulation of sPLA(2) and COX-2 expression by TGF-alpha and IL-1beta results in an increase in PGE(2). Prostaglandins E 135-138 interleukin 1 beta Rattus norvegicus 100-108 11352824-5 2001 Inhibition of activated NF-kappaB action resulted in suppression of both their mRNA expression and increases in PGE(2) and CINC-1 levels induced by interleukin-1beta. Prostaglandins E 112-115 interleukin 1 beta Rattus norvegicus 148-165 11403935-1 2001 We previously reported that cells other than mast cells or neurons could synthesize histamine in response to lipopolysaccharide (LPS) or interleukin 1beta in the rat brain. Histamine 84-93 interleukin 1 beta Rattus norvegicus 137-154 11458880-4 2001 This review article summarizes our major findings concerning the synthesis of TNF-alpha and IL-1beta in the uterus of diabetic rats, and in cultures of rodent uterine cells upon their exposure to high concentrations of glucose. Glucose 219-226 interleukin 1 beta Rattus norvegicus 92-100 11374865-5 2001 In rat islets exposed to a lower dose (1.5 U/ml) of IL-1beta, insulin secretion in response to glucose, but not to glyceraldehydes (GA), ketoisocaproate (KIC), or KCl, was selectively impaired, concomitantly with lower ATP concentrations in the presence of 16.7 mM glucose, while such suppression of insulin secretion and ATP content was not observed in heat shock-treated islets. Glucose 95-102 interleukin 1 beta Rattus norvegicus 52-60 11358894-11 2001 Omeprazole inhibited the effects of IL-1beta. Omeprazole 0-10 interleukin 1 beta Rattus norvegicus 36-44 11374865-4 2001 Exposure to a higher dose (15 U/ml) of interleukin-1beta (IL-1beta) abolished the insulin release by stimulation of glucose or KCl in both control and heat shocked islets. Glucose 116-123 interleukin 1 beta Rattus norvegicus 39-56 11374865-4 2001 Exposure to a higher dose (15 U/ml) of interleukin-1beta (IL-1beta) abolished the insulin release by stimulation of glucose or KCl in both control and heat shocked islets. Glucose 116-123 interleukin 1 beta Rattus norvegicus 58-66 11374865-4 2001 Exposure to a higher dose (15 U/ml) of interleukin-1beta (IL-1beta) abolished the insulin release by stimulation of glucose or KCl in both control and heat shocked islets. Potassium Chloride 127-130 interleukin 1 beta Rattus norvegicus 39-56 11374865-4 2001 Exposure to a higher dose (15 U/ml) of interleukin-1beta (IL-1beta) abolished the insulin release by stimulation of glucose or KCl in both control and heat shocked islets. Potassium Chloride 127-130 interleukin 1 beta Rattus norvegicus 58-66 11356709-3 2001 We presently investigated whether the viral replicative intermediate double stranded RNA [here used as synthetic polyinosinic-polycytidylic acid (PIC)] modifies the effects of IL-1beta and IFN-gamma on gene expression and viability of rat pancreatic beta-cells. Poly I-C 146-149 interleukin 1 beta Rattus norvegicus 176-184 11356709-13 2001 PIC has an additive effect on cytokine-induced beta-cell death by both NO-dependent (in the case of IL-1beta) and NO-independent (in the case of IFN-gamma) mechanisms. Poly I-C 0-3 interleukin 1 beta Rattus norvegicus 100-108 11422452-4 2001 A cotreatment of both culture systems with interleukin-1beta and interferon-gamma induced the protein expression of astrocytic inducible nitric oxide synthase (iNOS), resulting in increased nitric oxide (NO) production. Nitric Oxide 137-149 interleukin 1 beta Rattus norvegicus 43-60 11374865-5 2001 In rat islets exposed to a lower dose (1.5 U/ml) of IL-1beta, insulin secretion in response to glucose, but not to glyceraldehydes (GA), ketoisocaproate (KIC), or KCl, was selectively impaired, concomitantly with lower ATP concentrations in the presence of 16.7 mM glucose, while such suppression of insulin secretion and ATP content was not observed in heat shock-treated islets. Adenosine Triphosphate 219-222 interleukin 1 beta Rattus norvegicus 52-60 11374865-5 2001 In rat islets exposed to a lower dose (1.5 U/ml) of IL-1beta, insulin secretion in response to glucose, but not to glyceraldehydes (GA), ketoisocaproate (KIC), or KCl, was selectively impaired, concomitantly with lower ATP concentrations in the presence of 16.7 mM glucose, while such suppression of insulin secretion and ATP content was not observed in heat shock-treated islets. Glucose 265-272 interleukin 1 beta Rattus norvegicus 52-60 11374865-5 2001 In rat islets exposed to a lower dose (1.5 U/ml) of IL-1beta, insulin secretion in response to glucose, but not to glyceraldehydes (GA), ketoisocaproate (KIC), or KCl, was selectively impaired, concomitantly with lower ATP concentrations in the presence of 16.7 mM glucose, while such suppression of insulin secretion and ATP content was not observed in heat shock-treated islets. Adenosine Triphosphate 322-325 interleukin 1 beta Rattus norvegicus 52-60 11374865-7 2001 The glucose utilization rate measurement using [5-3H]-glucose and [2-3H]-glucose and the glucokinase activity in vitro were reduced in islets treated with 1.5 U/ml IL-1beta. Glucose 4-11 interleukin 1 beta Rattus norvegicus 164-172 11374865-7 2001 The glucose utilization rate measurement using [5-3H]-glucose and [2-3H]-glucose and the glucokinase activity in vitro were reduced in islets treated with 1.5 U/ml IL-1beta. [5-3h]-glucose 47-61 interleukin 1 beta Rattus norvegicus 164-172 11374865-7 2001 The glucose utilization rate measurement using [5-3H]-glucose and [2-3H]-glucose and the glucokinase activity in vitro were reduced in islets treated with 1.5 U/ml IL-1beta. [2-3h]-glucose 66-80 interleukin 1 beta Rattus norvegicus 164-172 11376495-14 2001 Indomethacin and ASA, which suppressed PGE(2) generation both in the non-ulcerated and ulcerated gastric mucosa, significantly delayed the rate of ulcer healing and this was accompanied by the fall in GBF at ulcer margin and further elevation of plasma IL-1beta and TNFalpha levels, which was sustained up to the end of the study. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 253-261 11459126-3 2001 We showed that the excitotoxin-induced microglia reaction, the expression of inducible nitric oxide synthase-positive cells and the production of interleukin-1beta and prostaglandin-E2 in the injected area were attenuated by the NO-flurbiprofen (15 mg/kg, p.o.) Flurbiprofen 232-244 interleukin 1 beta Rattus norvegicus 146-163 11376495-14 2001 Indomethacin and ASA, which suppressed PGE(2) generation both in the non-ulcerated and ulcerated gastric mucosa, significantly delayed the rate of ulcer healing and this was accompanied by the fall in GBF at ulcer margin and further elevation of plasma IL-1beta and TNFalpha levels, which was sustained up to the end of the study. Aspirin 17-20 interleukin 1 beta Rattus norvegicus 253-261 11376495-15 2001 Treatment with NS-398 and Vioxx, which caused only a moderate decrease in the PGE(2) generation in the non-ulcerated gastric mucosa, delayed ulcer healing and attenuated significantly the GBF at ulcer margin and PGE(2) generation in the ulcerated tissue, while raising the plasma IL-1beta and TNFalpha similarly to those observed in indomethacin- and ASA-treated rats. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 15-21 interleukin 1 beta Rattus norvegicus 280-288 11376495-15 2001 Treatment with NS-398 and Vioxx, which caused only a moderate decrease in the PGE(2) generation in the non-ulcerated gastric mucosa, delayed ulcer healing and attenuated significantly the GBF at ulcer margin and PGE(2) generation in the ulcerated tissue, while raising the plasma IL-1beta and TNFalpha similarly to those observed in indomethacin- and ASA-treated rats. rofecoxib 26-31 interleukin 1 beta Rattus norvegicus 280-288 11376495-16 2001 Resveratrol, which suppressed the PGE(2) generation in both non-ulcerated and ulcerated gastric mucosa, prolonged ulcer healing and this was accompanied by the fall in the GBF at the ulcer margin and a significant increase in plasma IL-1beta and TNFalpha levels. Resveratrol 0-11 interleukin 1 beta Rattus norvegicus 233-241 11390713-11 2001 Moreover, GEC proliferation cultured with K1 medium was partially inhibited by anti-IL-1beta neutralizing antibody. k1 medium 42-51 interleukin 1 beta Rattus norvegicus 84-92 11350047-4 2001 In the present study, 15d-PGJ2, but not TRO and other prostanoids, suppressed interleukin (IL)-1beta-induced PGE2 synthesis in rheumatoid synovial fibroblasts (RSFs) through the inhibition of cyclooxygenase (COX-2) and cytosolic phospholipase A2 (cPLA2) expression. 15-deoxyprostaglandin J2 22-30 interleukin 1 beta Rattus norvegicus 78-100 11469536-6 2001 The cAMP-elevator forskolin did not augment the cytokine-induced elevation of sPLA2-IIa enzyme activity but significantly increased the IL-1beta-stimulated sPLA2-IIa mRNA contents in endothelial cells. Colforsin 18-27 interleukin 1 beta Rattus norvegicus 136-144 11350047-4 2001 In the present study, 15d-PGJ2, but not TRO and other prostanoids, suppressed interleukin (IL)-1beta-induced PGE2 synthesis in rheumatoid synovial fibroblasts (RSFs) through the inhibition of cyclooxygenase (COX-2) and cytosolic phospholipase A2 (cPLA2) expression. Dinoprostone 109-113 interleukin 1 beta Rattus norvegicus 78-100 11344087-3 2001 Injection of carrageenan into the pleural cavity of rats elicited an acute inflammatory response characterized by fluid accumulation in the pleural cavity that contained many neutrophils (PMNs), an infiltration of PMNs in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate, tumor necrosis factor alpha, and interleukin 1beta. Carrageenan 13-24 interleukin 1 beta Rattus norvegicus 348-365 11299211-10 2001 The kappaB-responsive cytokines interleukin-1beta and tumor necrosis factor-alpha were transiently expressed in the CR group but persisted longer in the AL group. Chromium 116-118 interleukin 1 beta Rattus norvegicus 32-81 11299211-10 2001 The kappaB-responsive cytokines interleukin-1beta and tumor necrosis factor-alpha were transiently expressed in the CR group but persisted longer in the AL group. Aluminum 153-155 interleukin 1 beta Rattus norvegicus 32-81 11334407-6 2001 We also evaluated the effect of TIMP-1 on IL-1beta-induced inhibition of glucose-stimulated insulin secretion (GSIS) in freshly isolated rat pancreatic islets. Glucose 73-80 interleukin 1 beta Rattus norvegicus 42-50 11403685-1 2001 Single administration of the cytokine interleukin-1beta (IL-1) or the psychostimulant amphetamine causes long-term sensitization of the hypothalamus pituitary adrenal (HPA) axis, i.e. enhanced adrenocorticotropine hormone (ACTH) and corticosterone responses weeks later. Corticosterone 233-247 interleukin 1 beta Rattus norvegicus 38-55 11411959-0 2001 The new antirheumatic drug KE-298 suppresses monocyte chemoattractant protein (MCP)-1 and RANTES production in rats with adjuvant-induced arthritis and in IL-1beta-stimulated synoviocytes of patients with rheumatoid arthritis. esonarimod 27-33 interleukin 1 beta Rattus norvegicus 155-163 11382546-2 2001 Pretreatment of islets with IL-1beta for 1 h or 24 h inhibited the insulin secretion induced by glucose in both groups, but it was less marked in LP than in NP group. Glucose 96-103 interleukin 1 beta Rattus norvegicus 28-36 11382546-3 2001 Islets from LP rats exhibited a decreased IL-1beta-induced nitric oxide (NO) production, lower inhibition of D-[U(14)C]-glucose oxidation to (14)CO(2) and less pronounced effect of IL-1beta on alpha-ketoisocaproic acid-induced insulin secretion than NP islets. Nitric Oxide 59-71 interleukin 1 beta Rattus norvegicus 42-50 11382546-3 2001 Islets from LP rats exhibited a decreased IL-1beta-induced nitric oxide (NO) production, lower inhibition of D-[U(14)C]-glucose oxidation to (14)CO(2) and less pronounced effect of IL-1beta on alpha-ketoisocaproic acid-induced insulin secretion than NP islets. alpha-ketoisocaproic acid 193-218 interleukin 1 beta Rattus norvegicus 181-189 11420064-6 2001 The IL-1beta-induced decrease in body weight was inhibited by injections of genistein, but not by injections of chelerythrine or indomethacin. Genistein 76-85 interleukin 1 beta Rattus norvegicus 4-12 11411959-3 2001 Furthermore, KE-298 (10-100 microg/ml) suppressed MCP-1 and RANTES production by IL-1beta-stimulated RA synoviocytes through inhibition of NF-kappaB and AP-1 activation. esonarimod 13-19 interleukin 1 beta Rattus norvegicus 81-89 11340116-8 2001 In contrast, dietary caffeine significantly suppressed LPS-induced enhancement not only of plasma IL-1beta, IL-6, IL-10 and IFN-gamma concentrations, but also of TNF-alpha concentration. Caffeine 21-29 interleukin 1 beta Rattus norvegicus 98-106 11334877-0 2001 Methylenedioxymethamphetamine-induced suppression of interleukin-1beta and tumour necrosis factor-alpha is not mediated by serotonin. N-Methyl-3,4-methylenedioxyamphetamine 0-29 interleukin 1 beta Rattus norvegicus 53-103 11334877-2 2001 We examined the effect of pretreatment with the selective serotonin reuptake inhibitor paroxetine, and the tryptophan hydroxylase inhibitor para-chlorophenylalanine on MDMA-induced suppression of interleukin-1beta and tumour necrosis factor (TNF)-alpha secretion following an in vivo lipopolysaccharide challenge. Fenclonine 140-164 interleukin 1 beta Rattus norvegicus 196-213 11311405-6 2001 The effect of IL-1beta was completely abolished when we treated cells with inhibitor of mitogen-activated protein kinases (MAPKs) (PD98059) (25 microM), phospholipase A(2) inhibitor mepacrine (30 microM) and protein synthesis inhibitor cycloheximide (CHX) (10 microg/ml). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 131-138 interleukin 1 beta Rattus norvegicus 14-22 11334877-2 2001 We examined the effect of pretreatment with the selective serotonin reuptake inhibitor paroxetine, and the tryptophan hydroxylase inhibitor para-chlorophenylalanine on MDMA-induced suppression of interleukin-1beta and tumour necrosis factor (TNF)-alpha secretion following an in vivo lipopolysaccharide challenge. N-Methyl-3,4-methylenedioxyamphetamine 168-172 interleukin 1 beta Rattus norvegicus 196-213 11311405-6 2001 The effect of IL-1beta was completely abolished when we treated cells with inhibitor of mitogen-activated protein kinases (MAPKs) (PD98059) (25 microM), phospholipase A(2) inhibitor mepacrine (30 microM) and protein synthesis inhibitor cycloheximide (CHX) (10 microg/ml). Quinacrine 182-191 interleukin 1 beta Rattus norvegicus 14-22 11399523-0 2001 Glucose potentiates interleukin-1 beta (IL-1 beta)-induced p38 mitogen-activated protein kinase activity in rat pancreatic islets of Langerhans. Glucose 0-7 interleukin 1 beta Rattus norvegicus 20-38 11311405-6 2001 The effect of IL-1beta was completely abolished when we treated cells with inhibitor of mitogen-activated protein kinases (MAPKs) (PD98059) (25 microM), phospholipase A(2) inhibitor mepacrine (30 microM) and protein synthesis inhibitor cycloheximide (CHX) (10 microg/ml). Cycloheximide 236-249 interleukin 1 beta Rattus norvegicus 14-22 11311405-6 2001 The effect of IL-1beta was completely abolished when we treated cells with inhibitor of mitogen-activated protein kinases (MAPKs) (PD98059) (25 microM), phospholipase A(2) inhibitor mepacrine (30 microM) and protein synthesis inhibitor cycloheximide (CHX) (10 microg/ml). Cycloheximide 251-254 interleukin 1 beta Rattus norvegicus 14-22 11247753-0 2001 Role of nitric oxide in the cerebrovascular and thermoregulatory response to interleukin-1 beta. Nitric Oxide 8-20 interleukin 1 beta Rattus norvegicus 77-95 11247753-1 2001 Central administration of interleukin-1 beta (IL-1 beta) increases cerebral blood flow (CBF) and body temperature, in part, through the production of prostaglandins. Prostaglandins 150-164 interleukin 1 beta Rattus norvegicus 26-44 11247753-1 2001 Central administration of interleukin-1 beta (IL-1 beta) increases cerebral blood flow (CBF) and body temperature, in part, through the production of prostaglandins. Prostaglandins 150-164 interleukin 1 beta Rattus norvegicus 46-55 11247753-3 2001 In this study, we hypothesized that the increase in CBF occurs before any change in brain or body temperature and that the cerebrovascular and thermoregulatory effects of IL-1 beta would be attenuated by inhibiting the production of nitric oxide (NO). Nitric Oxide 233-245 interleukin 1 beta Rattus norvegicus 171-180 11247753-7 2001 Pretreatment with N(omega)-nitro-L-arginine methyl ester (L-NAME; 5 mg/kg iv) completely prevented the changes in cCBF and brain and rectal temperature induced by IL-1 beta. NG-Nitroarginine Methyl Ester 18-56 interleukin 1 beta Rattus norvegicus 163-172 11247753-7 2001 Pretreatment with N(omega)-nitro-L-arginine methyl ester (L-NAME; 5 mg/kg iv) completely prevented the changes in cCBF and brain and rectal temperature induced by IL-1 beta. NG-Nitroarginine Methyl Ester 58-64 interleukin 1 beta Rattus norvegicus 163-172 11287034-0 2001 Aspirin dose dependently inhibits the interleukin-1 beta-stimulated increase in inducible nitric oxide synthase, nitric oxide, and prostaglandin E(2) production in rat ovarian dispersates cultured in vitro. Aspirin 0-7 interleukin 1 beta Rattus norvegicus 38-56 11286988-2 2001 In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time-dependent manner, to produce high prostaglandin E(2) (PGE(2)) and nitrite (NO(2)(-)) levels in an apparently coordinated fashion. Prostaglandins E 134-149 interleukin 1 beta Rattus norvegicus 15-32 11286988-2 2001 In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time-dependent manner, to produce high prostaglandin E(2) (PGE(2)) and nitrite (NO(2)(-)) levels in an apparently coordinated fashion. Prostaglandins E 134-149 interleukin 1 beta Rattus norvegicus 34-42 11286988-2 2001 In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time-dependent manner, to produce high prostaglandin E(2) (PGE(2)) and nitrite (NO(2)(-)) levels in an apparently coordinated fashion. Prostaglandins E 154-157 interleukin 1 beta Rattus norvegicus 15-32 11286988-2 2001 In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time-dependent manner, to produce high prostaglandin E(2) (PGE(2)) and nitrite (NO(2)(-)) levels in an apparently coordinated fashion. Prostaglandins E 154-157 interleukin 1 beta Rattus norvegicus 34-42 11286988-2 2001 In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time-dependent manner, to produce high prostaglandin E(2) (PGE(2)) and nitrite (NO(2)(-)) levels in an apparently coordinated fashion. Nitrites 166-173 interleukin 1 beta Rattus norvegicus 15-32 11286988-2 2001 In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time-dependent manner, to produce high prostaglandin E(2) (PGE(2)) and nitrite (NO(2)(-)) levels in an apparently coordinated fashion. Nitrites 166-173 interleukin 1 beta Rattus norvegicus 34-42 11286988-10 2001 In tridimensional culture, IL-1beta inhibited radiolabelled sodium sulphate incorporation while stimulating COX-2 and NOS II activities. sodium sulfate 60-75 interleukin 1 beta Rattus norvegicus 27-35 11237998-3 2001 In lungs precontracted with methacholine, IL-1beta alone and IL-1beta/TNF-alpha decreased airway resistance 10 min after administration, whereas TNF-alpha alone had no effect. Methacholine Chloride 28-40 interleukin 1 beta Rattus norvegicus 61-69 11237998-8 2001 However, at later time points (after 40 min), IL-1beta and TNF-alpha in concert cause a COX-2- and thromboxane-dependent bronchoconstriction. Thromboxanes 99-110 interleukin 1 beta Rattus norvegicus 46-54 11309243-8 2001 Alternatively, SB 203580 (100 mg kg(-1)) produced dose-related inhibition of BAL IL-1beta levels (67.5% inhibition, P<0.01) and BAL neutrophilia (45.9% inhibition, P<0.01) 4 h after LPS challenge. SB 203580 15-24 interleukin 1 beta Rattus norvegicus 81-89 11287034-0 2001 Aspirin dose dependently inhibits the interleukin-1 beta-stimulated increase in inducible nitric oxide synthase, nitric oxide, and prostaglandin E(2) production in rat ovarian dispersates cultured in vitro. Nitric Oxide 90-102 interleukin 1 beta Rattus norvegicus 38-56 11287034-0 2001 Aspirin dose dependently inhibits the interleukin-1 beta-stimulated increase in inducible nitric oxide synthase, nitric oxide, and prostaglandin E(2) production in rat ovarian dispersates cultured in vitro. Dinoprostone 131-149 interleukin 1 beta Rattus norvegicus 38-56 11287034-1 2001 OBJECTIVE: Determine if aspirin inhibits the IL-1 beta-stimulated expression of inducible nitric oxide synthase (iNOS), nitric oxide (NO), and prostaglandin E(2) (PGE(2)) in rat ovarian dispersates cultured in vitro. Aspirin 24-31 interleukin 1 beta Rattus norvegicus 45-54 11399523-0 2001 Glucose potentiates interleukin-1 beta (IL-1 beta)-induced p38 mitogen-activated protein kinase activity in rat pancreatic islets of Langerhans. Glucose 0-7 interleukin 1 beta Rattus norvegicus 40-49 11287034-1 2001 OBJECTIVE: Determine if aspirin inhibits the IL-1 beta-stimulated expression of inducible nitric oxide synthase (iNOS), nitric oxide (NO), and prostaglandin E(2) (PGE(2)) in rat ovarian dispersates cultured in vitro. Nitric Oxide 90-102 interleukin 1 beta Rattus norvegicus 45-54 11287034-1 2001 OBJECTIVE: Determine if aspirin inhibits the IL-1 beta-stimulated expression of inducible nitric oxide synthase (iNOS), nitric oxide (NO), and prostaglandin E(2) (PGE(2)) in rat ovarian dispersates cultured in vitro. Dinoprostone 143-161 interleukin 1 beta Rattus norvegicus 45-54 11352557-0 2001 Regulation of lactate production by FSH, iL1beta, and TNFalpha in rat Sertoli cells. Lactic Acid 14-21 interleukin 1 beta Rattus norvegicus 41-48 11399523-2 2001 IL-1 beta causes expression of inducible nitric oxide synthase (iNOS) and production of nitric oxide (NO). Nitric Oxide 41-53 interleukin 1 beta Rattus norvegicus 0-9 11352557-2 2001 The present study shows that, as in porcine Sertoli cells, interleukin (IL)1beta and follicle-stimulating hormone (FSH) increase lactate production in rat Sertoli cells (basal, 9.1 +/- 1.0; FSH (100 ng/ml), 16.6 +/- 2.0; IL1beta (50 ng/ml), 13.3 +/- 1.6 microg/microg DNA). Lactic Acid 129-136 interleukin 1 beta Rattus norvegicus 59-80 11287034-1 2001 OBJECTIVE: Determine if aspirin inhibits the IL-1 beta-stimulated expression of inducible nitric oxide synthase (iNOS), nitric oxide (NO), and prostaglandin E(2) (PGE(2)) in rat ovarian dispersates cultured in vitro. Prostaglandins E 163-166 interleukin 1 beta Rattus norvegicus 45-54 11287034-9 2001 RESULT(S): Administration of IL-1 beta increased nitrite and PGE(2) levels over that observed in the control group after culture of ovarian dispersates for 24 and 48 hours. Nitrites 49-56 interleukin 1 beta Rattus norvegicus 29-38 11399523-4 2001 Glucose has been shown to modulate the effects of IL-1 beta on accumulated insulin release and potentiate NO production in rat islets, but the biochemical mechanism is unknown. Glucose 0-7 interleukin 1 beta Rattus norvegicus 50-59 11287034-9 2001 RESULT(S): Administration of IL-1 beta increased nitrite and PGE(2) levels over that observed in the control group after culture of ovarian dispersates for 24 and 48 hours. Prostaglandins E 61-64 interleukin 1 beta Rattus norvegicus 29-38 11352557-4 2001 Differences in the period required by IL1beta to increase glucose uptake, as compared with the porcine model, have been observed. Glucose 58-65 interleukin 1 beta Rattus norvegicus 38-45 11399523-7 2001 The aim of this study was to investigate whether glucose potentiated IL-1 beta-induced p38 and ERK1/2 activity in rat islets. Glucose 49-56 interleukin 1 beta Rattus norvegicus 69-78 11287034-10 2001 Aspirin dose dependently reduced the IL-1 beta-stimulated increase in nitrite production from ovarian dispersates after culture for 24 and 48 hours. Aspirin 0-7 interleukin 1 beta Rattus norvegicus 37-46 11287034-10 2001 Aspirin dose dependently reduced the IL-1 beta-stimulated increase in nitrite production from ovarian dispersates after culture for 24 and 48 hours. Nitrites 70-77 interleukin 1 beta Rattus norvegicus 37-46 11287034-12 2001 Coadministration of IL-1 beta and aspirin (10 mM) attenuates IL-1 beta-stimulated iNOS expression after culture for 24 and 48 hours. Aspirin 34-41 interleukin 1 beta Rattus norvegicus 61-70 11287034-13 2001 CONCLUSION(S): Aspirin significantly inhibits the IL-1 beta-stimulated expression of iNOS, NO, and PGE(2) in ovarian dispersates cultured in vitro. Aspirin 15-22 interleukin 1 beta Rattus norvegicus 50-59 11287034-13 2001 CONCLUSION(S): Aspirin significantly inhibits the IL-1 beta-stimulated expression of iNOS, NO, and PGE(2) in ovarian dispersates cultured in vitro. Prostaglandins E 99-102 interleukin 1 beta Rattus norvegicus 50-59 11399523-9 2001 D-glucose potentiated the p38 activity induced by a low concentration of IL-1 beta, whereas no effect was seen at high concentrations of IL-1 beta. Glucose 0-9 interleukin 1 beta Rattus norvegicus 73-82 11399523-10 2001 Inhibition of p38 activity prevented IL-1 beta-induced nitrite production in the presence of D-glucose. Nitrites 55-62 interleukin 1 beta Rattus norvegicus 37-46 11399523-10 2001 Inhibition of p38 activity prevented IL-1 beta-induced nitrite production in the presence of D-glucose. Glucose 93-102 interleukin 1 beta Rattus norvegicus 37-46 11399523-11 2001 We conclude that IL-1 beta-induced NO production in the presence of glucose is signalled by the p38 pathway. Glucose 68-75 interleukin 1 beta Rattus norvegicus 17-26 11260389-4 2001 METHODS: Synthesis of prostanoid by resting and interleukin-1beta (IL-1beta)-treated (overnight) RGMCs from exogenous or endogenous arachidonic acid (AA) was assessed by high-performance liquid chromtography or enzyme immunoassay, respectively. Prostaglandins 22-32 interleukin 1 beta Rattus norvegicus 48-65 11275558-3 2001 N2733 dose-dependently (10-100 microM) inhibited IL-1beta-stimulated NO production, and decreased IL-1beta-induced iNOS mRNA and protein expression, as found on Northern and Western blot analyses, respectively. 1-(3-(3-pyridyl)acryloyl)-2-pyrrolidinone 0-5 interleukin 1 beta Rattus norvegicus 49-57 11275558-3 2001 N2733 dose-dependently (10-100 microM) inhibited IL-1beta-stimulated NO production, and decreased IL-1beta-induced iNOS mRNA and protein expression, as found on Northern and Western blot analyses, respectively. 1-(3-(3-pyridyl)acryloyl)-2-pyrrolidinone 0-5 interleukin 1 beta Rattus norvegicus 98-106 11275558-4 2001 Gel shift assay and an immunocytochemical study showed that N2733 inhibited IL-1beta-induced NF-kappaB activation and its nuclear translocation. 1-(3-(3-pyridyl)acryloyl)-2-pyrrolidinone 60-65 interleukin 1 beta Rattus norvegicus 76-84 11275558-6 2001 N2733 blocked IL-1beta-induced phosphorylated IkappaB-alpha even in the presence of a proteasome inhibitor (MG115). 1-(3-(3-pyridyl)acryloyl)-2-pyrrolidinone 0-5 interleukin 1 beta Rattus norvegicus 14-22 11275558-6 2001 N2733 blocked IL-1beta-induced phosphorylated IkappaB-alpha even in the presence of a proteasome inhibitor (MG115). carbobenzoxy-leucyl-leucyl-norvalinal 108-113 interleukin 1 beta Rattus norvegicus 14-22 11275558-7 2001 Immunoblot analysis involving anti-IkappaB kinase (IKK)-alpha and anti-phosphoserine antibodies revealed that N2733 inhibited IL-1beta-induced IKK-alpha phosphorylation, whereas N2733 had no inhibitory effect on IL-1beta-stimulated p42/p44 MAP kinase or p38 MAP kinase activity. 1-(3-(3-pyridyl)acryloyl)-2-pyrrolidinone 110-115 interleukin 1 beta Rattus norvegicus 126-134 11275558-8 2001 Our results suggest that the inhibitory action of N2733 toward IL-1beta-induced NF-kappaB activation and iNOS expression is due to its blockade of the upstream signal(s) leading to IKK-alpha activation, and subsequent phosphorylation and degradation of IkappaB-alpha in rat VSMCs. 1-(3-(3-pyridyl)acryloyl)-2-pyrrolidinone 50-55 interleukin 1 beta Rattus norvegicus 63-71 11316326-1 2001 In the present study, we examined whether melatonin can protect rodent pancreatic islets against streptozotocin (STZ) and interleukin-1beta (IL-1beta)-induced suppression of beta-cell function. Melatonin 42-51 interleukin 1 beta Rattus norvegicus 122-139 11316326-1 2001 In the present study, we examined whether melatonin can protect rodent pancreatic islets against streptozotocin (STZ) and interleukin-1beta (IL-1beta)-induced suppression of beta-cell function. Melatonin 42-51 interleukin 1 beta Rattus norvegicus 141-149 11316326-3 2001 Activation of inducible nitric oxide synthase and nitric oxide (NO) formation may cause IL-1beta -induced beta-cell impairment. nitric 24-30 interleukin 1 beta Rattus norvegicus 88-96 11316326-3 2001 Activation of inducible nitric oxide synthase and nitric oxide (NO) formation may cause IL-1beta -induced beta-cell impairment. Nitric Oxide 24-36 interleukin 1 beta Rattus norvegicus 88-96 11260389-4 2001 METHODS: Synthesis of prostanoid by resting and interleukin-1beta (IL-1beta)-treated (overnight) RGMCs from exogenous or endogenous arachidonic acid (AA) was assessed by high-performance liquid chromtography or enzyme immunoassay, respectively. Prostaglandins 22-32 interleukin 1 beta Rattus norvegicus 67-75 11346186-0 2001 Enhanced production of IL-1beta and IL-6 following endotoxin challenge in rats with dietary magnesium deficiency. Magnesium 92-101 interleukin 1 beta Rattus norvegicus 23-31 11260389-4 2001 METHODS: Synthesis of prostanoid by resting and interleukin-1beta (IL-1beta)-treated (overnight) RGMCs from exogenous or endogenous arachidonic acid (AA) was assessed by high-performance liquid chromtography or enzyme immunoassay, respectively. Arachidonic Acid 132-148 interleukin 1 beta Rattus norvegicus 67-75 11346186-4 2001 Levels of mRNA for IL-1beta, IL-6 and TNFalpha in alveolar macrophages showed a tendency to decrease during Mg deficiency, but the levels of IL-1beta and TNFalpha mRNAs after endotoxin challenge were higher in Mg-deficient rats than in controls. Magnesium 108-110 interleukin 1 beta Rattus norvegicus 19-27 11260389-8 2001 SnCl2 totally deviated formation of PGE2 and PGD2 toward PGF2alpha in resting RGMCs, whereas PGE2 was only partially deviated toward PGF2alpha in IL-1beta-treated RGMCs. Dinoprostone 93-97 interleukin 1 beta Rattus norvegicus 146-154 11260389-10 2001 Aspirin-treated platelets formed TXB2 when either RGMCs or intact glomeruli were present in the incubation and formation of TXB2 was approximately fourfold higher with IL-1beta-treated RGMCs or glomeruli. Aspirin 0-7 interleukin 1 beta Rattus norvegicus 168-176 11260389-11 2001 CONCLUSIONS: RGMCs and intact glomeruli released substantial amounts of untransformed PGH2, which was enhanced following exposure to IL-1beta. Prostaglandin H2 86-90 interleukin 1 beta Rattus norvegicus 133-141 11290377-10 2001 The effect of interleukin-1 beta + bradykinin was abolished by adding 10 nM hydrocortisone (suppressing phospholipase A2 and cyclooxygenase) or 1 microM indomethacin (inhibiting cyclooxygenase). Hydrocortisone 76-90 interleukin 1 beta Rattus norvegicus 14-32 11290377-0 2001 Isolated rat stomach ECL cells generate prostaglandin E(2) in response to interleukin-1 beta, tumor necrosis factor-alpha and bradykinin. Dinoprostone 40-58 interleukin 1 beta Rattus norvegicus 74-121 11312373-9 2001 CONCLUSIONS: Liposomally conjugated MTX may exert its beneficial effects in experimental arthritis through IL-1beta and IL-6 inhibition. Methotrexate 36-39 interleukin 1 beta Rattus norvegicus 107-115 11290377-10 2001 The effect of interleukin-1 beta + bradykinin was abolished by adding 10 nM hydrocortisone (suppressing phospholipase A2 and cyclooxygenase) or 1 microM indomethacin (inhibiting cyclooxygenase). Indomethacin 153-165 interleukin 1 beta Rattus norvegicus 14-32 11290377-11 2001 Incubating ECL cells in the presence of interleukin-1 beta+bradykinin for 24 h reduced their ability to secrete histamine in response to gastrin. Histamine 112-121 interleukin 1 beta Rattus norvegicus 40-58 11251208-0 2001 Inhibition of interleukin-1beta and prostaglandin E(2) thermogenesis by glycyl-glutamine, a pro-opiomelanocortin-derived peptide. glycylglutamine 72-88 interleukin 1 beta Rattus norvegicus 14-31 11251208-5 2001 Interleukin-1beta (1 U) injection into the same PGE(2) responsive thermogenic sites in the mPOA elicited a prolonged rise in colonic temperature (T(c)) (+1.02+/-0.06 degrees C) that persisted for at least 2 h. Glycyl-glutamine (3 nmol) co-injection into the mPOA inhibited IL-1beta thermogenesis completely (T(c)=-0.18+/-0.22 degrees C). Prostaglandins E 48-51 interleukin 1 beta Rattus norvegicus 0-17 11251208-5 2001 Interleukin-1beta (1 U) injection into the same PGE(2) responsive thermogenic sites in the mPOA elicited a prolonged rise in colonic temperature (T(c)) (+1.02+/-0.06 degrees C) that persisted for at least 2 h. Glycyl-glutamine (3 nmol) co-injection into the mPOA inhibited IL-1beta thermogenesis completely (T(c)=-0.18+/-0.22 degrees C). glycylglutamine 210-226 interleukin 1 beta Rattus norvegicus 0-17 11251208-8 2001 Glycyl-glutamine (3 nmol) also prevented the rise in body temperature produced by PGE(2) (PGE(2)=0.89+/-0.05 degrees C; PGE(2) plus Gly-Gln=-0.16+/-0.14 degrees C), consistent with evidence that PGE(2) mediates IL-1beta-induced fever. glycylglutamine 0-16 interleukin 1 beta Rattus norvegicus 211-219 11251208-1 2001 Interleukin-1beta (IL-1beta) and other cytokines produce fever by stimulating prostaglandin E(2) (PGE(2)) synthesis in thermoregulatory regions of the preoptic area and anterior hypothalamus (POA/AH). Dinoprostone 78-96 interleukin 1 beta Rattus norvegicus 0-17 11251208-1 2001 Interleukin-1beta (IL-1beta) and other cytokines produce fever by stimulating prostaglandin E(2) (PGE(2)) synthesis in thermoregulatory regions of the preoptic area and anterior hypothalamus (POA/AH). Dinoprostone 78-96 interleukin 1 beta Rattus norvegicus 19-27 11251208-1 2001 Interleukin-1beta (IL-1beta) and other cytokines produce fever by stimulating prostaglandin E(2) (PGE(2)) synthesis in thermoregulatory regions of the preoptic area and anterior hypothalamus (POA/AH). Prostaglandins E 98-101 interleukin 1 beta Rattus norvegicus 0-17 11251208-1 2001 Interleukin-1beta (IL-1beta) and other cytokines produce fever by stimulating prostaglandin E(2) (PGE(2)) synthesis in thermoregulatory regions of the preoptic area and anterior hypothalamus (POA/AH). Prostaglandins E 98-101 interleukin 1 beta Rattus norvegicus 19-27 11164953-15 2001 Proposed inhibitors such as peptide YY, neuropeptide Y and the cytokines interleukin 1-beta and tumor necrosis factor alpha induced at best a moderate inhibition of gastrin- or PACAP-stimulated secretion at high concentrations, while calcitonin gene-related peptide, pancreatic polypeptide and histamine itself were without effect. Histamine 294-303 interleukin 1 beta Rattus norvegicus 73-91 11251208-3 2001 In this study, we investigated whether glycyl-glutamine (beta-endorphin(30-31)), an inhibitory dipeptide synthesized from beta-endorphin post-translationally, inhibits IL-1beta and PGE(2)-induced hyperthermia. glycylglutamine 39-55 interleukin 1 beta Rattus norvegicus 168-176 11282554-8 2001 Cytokine transcripts in the colon were modified by these treatments: IFN-gamma and IL-1beta were decreased after dexamethasone treatment, whereas administration of L-NIL resulted in decreased IFN-gamma, and TNF-alpha. Dexamethasone 113-126 interleukin 1 beta Rattus norvegicus 83-91 11171635-0 2001 Interleukin-1beta enhances retinoic acid-mediated expression of bone-type alkaline phosphatase in rat IEC-6 cells. Tretinoin 27-40 interleukin 1 beta Rattus norvegicus 0-17 11171635-4 2001 In contrast, IL-1beta markedly increased the activity, protein, and mRNA of the bone-type ALP only when RA was present. Tretinoin 104-106 interleukin 1 beta Rattus norvegicus 13-21 11223862-8 2001 In addition, neuroprotective plasma concentrations of SB 239063 that reduced p38 activity following stroke also reduced the stroke-induced expression of IL-1beta and TNFalpha (i.e., cytokines known to contribute to stroke-induced brain injury). Antimony 54-56 interleukin 1 beta Rattus norvegicus 153-161 11170729-6 2001 QUIS injections also resulted in an increase in mRNA levels of interleukin-1 beta (IL-1 beta), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), CD95 ligand (CD95-L, also called FAS-L/APO-1L), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Quisqualic Acid 0-4 interleukin 1 beta Rattus norvegicus 63-81 11170729-6 2001 QUIS injections also resulted in an increase in mRNA levels of interleukin-1 beta (IL-1 beta), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), CD95 ligand (CD95-L, also called FAS-L/APO-1L), and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Quisqualic Acid 0-4 interleukin 1 beta Rattus norvegicus 83-92 11259370-5 2001 Moreover, inhibition of IL-1b-induced endogenous NO formation by the NO-synthase (NOS) inhibitor L-NMMA markedly attenuated MIP-2 protein expression. omega-N-Methylarginine 97-103 interleukin 1 beta Rattus norvegicus 24-29 11300617-5 2001 When IL-1beta or IL-6 was added to the culture medium, the Hp mRNA level increased much more in the hepatocytes cultured in low Mg2+ medium (Mg2+; 0.46 mM) than in those cultured in the control Mg2+ medium (Mg2+; 0.92 mM). magnesium ion 128-132 interleukin 1 beta Rattus norvegicus 5-13 11165036-7 2001 However, both TNFalpha and IL-1beta caused a dose-dependent inhibition of the recombinant FSH-induced enzyme activity and the Forskoline-induced expression of 17HSD type 1 and P450arom mRNAs. forskoline 126-136 interleukin 1 beta Rattus norvegicus 27-35 11300617-5 2001 When IL-1beta or IL-6 was added to the culture medium, the Hp mRNA level increased much more in the hepatocytes cultured in low Mg2+ medium (Mg2+; 0.46 mM) than in those cultured in the control Mg2+ medium (Mg2+; 0.92 mM). magnesium ion 141-145 interleukin 1 beta Rattus norvegicus 5-13 11300617-5 2001 When IL-1beta or IL-6 was added to the culture medium, the Hp mRNA level increased much more in the hepatocytes cultured in low Mg2+ medium (Mg2+; 0.46 mM) than in those cultured in the control Mg2+ medium (Mg2+; 0.92 mM). magnesium ion 141-145 interleukin 1 beta Rattus norvegicus 5-13 11300617-5 2001 When IL-1beta or IL-6 was added to the culture medium, the Hp mRNA level increased much more in the hepatocytes cultured in low Mg2+ medium (Mg2+; 0.46 mM) than in those cultured in the control Mg2+ medium (Mg2+; 0.92 mM). magnesium ion 141-145 interleukin 1 beta Rattus norvegicus 5-13 11087760-1 2001 Exposure of pancreatic islets to cytokines such as interleukin (IL)-1beta induces a variety of proinflammatory genes including type II nitric-oxide synthase (iNOS) which produces nitric oxide (NO). Nitric Oxide 179-191 interleukin 1 beta Rattus norvegicus 51-73 11165036-10 2001 Despite the presence of inhibitors of protein kinase C (staurosporine) or tyrosine kinases (genistein), the inhibitory effects of TNFalpha and IL-1beta on the Forskoline-induced expression of 17HSD type 1 and P450arom and the Forskoline-induced 17HSD activity were not blocked. forskoline 159-169 interleukin 1 beta Rattus norvegicus 143-151 11530235-9 2001 However, rotenone inhibited NOS-2 and COX-2 proteins and associated nitric oxide and prostaglandin E(2) production, respectively, suggesting a posttranscriptional target for interleukin 1beta-mediated regulation of NOS-2 and COX-2 gene expression. Rotenone 9-17 interleukin 1 beta Rattus norvegicus 174-191 11159015-7 2001 However, both staurosporine- and IL-1beta-induced phosphorylation of p38 mitogen-activated protein kinase and upregulation of PDGFR-alpha by these two agents was inhibited by the p38 inhibitor SB-203580. SB 203580 193-202 interleukin 1 beta Rattus norvegicus 33-41 11139783-11 2001 Serum LH and testosterone levels were considerably reduced at 6 h and 18 h after LPS treatment, and had not completely recovered by 72 h. At 6 h after injection, DEX inhibited basal IL-1beta expression and the LPS-induced increase of IL-1beta mRNA levels in the liver, but had no effect on IL-1beta in the testis. Dexamethasone 162-165 interleukin 1 beta Rattus norvegicus 182-190 11139783-11 2001 Serum LH and testosterone levels were considerably reduced at 6 h and 18 h after LPS treatment, and had not completely recovered by 72 h. At 6 h after injection, DEX inhibited basal IL-1beta expression and the LPS-induced increase of IL-1beta mRNA levels in the liver, but had no effect on IL-1beta in the testis. Dexamethasone 162-165 interleukin 1 beta Rattus norvegicus 234-242 11139783-11 2001 Serum LH and testosterone levels were considerably reduced at 6 h and 18 h after LPS treatment, and had not completely recovered by 72 h. At 6 h after injection, DEX inhibited basal IL-1beta expression and the LPS-induced increase of IL-1beta mRNA levels in the liver, but had no effect on IL-1beta in the testis. Dexamethasone 162-165 interleukin 1 beta Rattus norvegicus 234-242 11139783-12 2001 The effects of DEX on IL-1beta levels in the liver were no longer evident by 18 h. In LPS-treated rats, DEX caused a significant reversal of the inhibition of serum LH and testosterone at 18 h, although not at 6 h or 72 h. Accordingly, DEX inhibited the systemic inflammatory response, but had no direct effect on either testicular steroidogenesis or intra-testicular inflammation, at the dose employed. Dexamethasone 15-18 interleukin 1 beta Rattus norvegicus 22-30 11139783-12 2001 The effects of DEX on IL-1beta levels in the liver were no longer evident by 18 h. In LPS-treated rats, DEX caused a significant reversal of the inhibition of serum LH and testosterone at 18 h, although not at 6 h or 72 h. Accordingly, DEX inhibited the systemic inflammatory response, but had no direct effect on either testicular steroidogenesis or intra-testicular inflammation, at the dose employed. Dexamethasone 104-107 interleukin 1 beta Rattus norvegicus 22-30 11139783-12 2001 The effects of DEX on IL-1beta levels in the liver were no longer evident by 18 h. In LPS-treated rats, DEX caused a significant reversal of the inhibition of serum LH and testosterone at 18 h, although not at 6 h or 72 h. Accordingly, DEX inhibited the systemic inflammatory response, but had no direct effect on either testicular steroidogenesis or intra-testicular inflammation, at the dose employed. Dexamethasone 104-107 interleukin 1 beta Rattus norvegicus 22-30 11530235-1 2001 Interleukin 1beta induced both nitric oxide synthase 2 (NOS-2) and cyclooxygenase 2 (COX-2) gene expression in dorsal root ganglion explant culture with increased NOS-2 and COX-2 activities, and corresponding increases in the production of nitric oxide and prostaglandin E(2). Nitric Oxide 31-43 interleukin 1 beta Rattus norvegicus 0-17 11530235-1 2001 Interleukin 1beta induced both nitric oxide synthase 2 (NOS-2) and cyclooxygenase 2 (COX-2) gene expression in dorsal root ganglion explant culture with increased NOS-2 and COX-2 activities, and corresponding increases in the production of nitric oxide and prostaglandin E(2). Prostaglandins E 257-272 interleukin 1 beta Rattus norvegicus 0-17 11530235-4 2001 Reactive oxygen species play an important role in inflammatory processes as mediators of injury, and potentially as intracellular signaling molecules in interleukin 1beta-mediated regulation of gene expression. Reactive Oxygen Species 0-23 interleukin 1 beta Rattus norvegicus 153-170 11530235-6 2001 The oxidant scavenger pyrrolidine dithiocarbamate abolished interleukin 1beta-induced NOS-2 mRNA accumulation and decreased nitric oxide production in a concentration-dependent manner, thus indicating that this antioxidant decreased either the transcription of NOS-2 gene or the stability of NOS-2 mRNA. pyrrolidine dithiocarbamic acid 22-49 interleukin 1 beta Rattus norvegicus 60-77 11530235-6 2001 The oxidant scavenger pyrrolidine dithiocarbamate abolished interleukin 1beta-induced NOS-2 mRNA accumulation and decreased nitric oxide production in a concentration-dependent manner, thus indicating that this antioxidant decreased either the transcription of NOS-2 gene or the stability of NOS-2 mRNA. Nitric Oxide 124-136 interleukin 1 beta Rattus norvegicus 60-77 11229466-0 2001 Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes. Glucosamine 144-155 interleukin 1 beta Rattus norvegicus 0-17 11229466-0 2001 Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes. Glucosamine 144-155 interleukin 1 beta Rattus norvegicus 159-176 11229466-1 2001 OBJECTIVE: To assess the variations of galactose-beta-1,3-glucuronosyltransferase I (GlcAT-I) expression related to the decrease in proteoglycan synthesis mediated by interleukin-1beta (IL-1beta) in rat chondrocytes, and to evaluate the influence of glucosamine on the effects elicited by this proinflammatory cytokine. Glucosamine 250-261 interleukin 1 beta Rattus norvegicus 167-184 11229466-8 2001 In addition, glucosamine was able to prevent, in a dose-dependent manner, the inhibitory effects of IL-1beta. Glucosamine 13-24 interleukin 1 beta Rattus norvegicus 100-108 11229466-9 2001 In the same way, the amino sugar reduced NO2- and PGE2 production induced by IL-1beta. Amino Sugars 21-32 interleukin 1 beta Rattus norvegicus 77-85 11229466-9 2001 In the same way, the amino sugar reduced NO2- and PGE2 production induced by IL-1beta. Nitrogen Dioxide 41-44 interleukin 1 beta Rattus norvegicus 77-85 11229466-9 2001 In the same way, the amino sugar reduced NO2- and PGE2 production induced by IL-1beta. Dinoprostone 50-54 interleukin 1 beta Rattus norvegicus 77-85 11229466-10 2001 Finally, the up-regulation of stromelysin 1 (MMP-3) mRNA expression by IL-1beta was fully prevented by glucosamine. Glucosamine 103-114 interleukin 1 beta Rattus norvegicus 71-79 11229466-11 2001 CONCLUSION: The results of this study suggest that the deleterious effect of IL-1beta on the anabolism of proteoglycan could involve the repression of GlcAT-I, a key enzyme in the biosynthesis of glycosaminoglycan. Glycosaminoglycans 196-213 interleukin 1 beta Rattus norvegicus 77-85 11229466-12 2001 Glucosamine was highly effective in preventing these IL-1beta-mediated suppressive effects. Glucosamine 0-11 interleukin 1 beta Rattus norvegicus 53-61 12045362-10 2001 These results demonstrate that variable-size hypothalamic damage (a larger lesion produced in AHA by NMA treatment vs. a smaller lesion control after aCSF) can result in a differential blunting of PRL, IL-1beta and ACTH release into blood in the face of robust, unmodulated corticosterone increases. N-methyl-DL-aspartic acid 101-104 interleukin 1 beta Rattus norvegicus 202-210 12045362-11 2001 In summary, these findings revealed a consistent predominant influence of ENDO on adrenal release of corticosterone as a concomitant to differential IL-1beta, ACTH and PRL release after AHA cell loss. Corticosterone 101-115 interleukin 1 beta Rattus norvegicus 149-157 11530235-9 2001 However, rotenone inhibited NOS-2 and COX-2 proteins and associated nitric oxide and prostaglandin E(2) production, respectively, suggesting a posttranscriptional target for interleukin 1beta-mediated regulation of NOS-2 and COX-2 gene expression. Nitric Oxide 68-80 interleukin 1 beta Rattus norvegicus 174-191 11530235-9 2001 However, rotenone inhibited NOS-2 and COX-2 proteins and associated nitric oxide and prostaglandin E(2) production, respectively, suggesting a posttranscriptional target for interleukin 1beta-mediated regulation of NOS-2 and COX-2 gene expression. Dinoprostone 85-103 interleukin 1 beta Rattus norvegicus 174-191 11530235-10 2001 Furthermore, both pyrrolidine dithiocarbamate and rotenone also decreased interleukin 1beta-induced 8-isoprostaglandin F(2alpha) production. pyrrolidine dithiocarbamic acid 18-45 interleukin 1 beta Rattus norvegicus 74-91 11530235-10 2001 Furthermore, both pyrrolidine dithiocarbamate and rotenone also decreased interleukin 1beta-induced 8-isoprostaglandin F(2alpha) production. Rotenone 50-58 interleukin 1 beta Rattus norvegicus 74-91 11530235-10 2001 Furthermore, both pyrrolidine dithiocarbamate and rotenone also decreased interleukin 1beta-induced 8-isoprostaglandin F(2alpha) production. 8-isoprostaglandin f 100-120 interleukin 1 beta Rattus norvegicus 74-91 11124973-3 2000 IL-1beta (10 ng/ml) treatment of rat striatal slices preloaded with (45)Ca(2+) elicited a delayed (30 min) and sustained increase (125-150%) in spontaneous (45)Ca(2+) release that was potentiated by l-arginine (300 microm) and counteracted by N-omega-nitro-l-arginine methyl ester (l-NAME) (1 and 3 mm). Arginine 199-209 interleukin 1 beta Rattus norvegicus 0-8 11178769-5 2001 RESULTS: The plasma IL-1beta and IL-6 levels in the PP-CO2, AWL-CO2, and AWL-He groups were significantly lower than those in AWL-Air group at 6 h (p < 0.05). Carbon Dioxide 64-67 interleukin 1 beta Rattus norvegicus 20-28 11178769-5 2001 RESULTS: The plasma IL-1beta and IL-6 levels in the PP-CO2, AWL-CO2, and AWL-He groups were significantly lower than those in AWL-Air group at 6 h (p < 0.05). Helium 77-79 interleukin 1 beta Rattus norvegicus 20-28 11178769-6 2001 The PLF IL-1beta (at 3, 6, and 24 h) and IL-6 (at 6 h) levels in the AWL-CO2 group were significantly lower than those in the AWL-Air group (p < 0.05). Carbon Dioxide 73-76 interleukin 1 beta Rattus norvegicus 8-16 11218240-10 2001 CONCLUSIONS: Our results suggest that treatment with the PAF inhibitor lexipafant and monoclonal antibodies against ICAM-1 or, seemingly most efficient, PECAM-1 reduces the severity of I/R-associated intestinal dysfunction, associated with a decrease in systemic concentrations of IL-1beta local leukocyte recruitment, and partly restoring plasma protease inhibitor levels. lexipafant 71-81 interleukin 1 beta Rattus norvegicus 281-289 11282287-10 2000 TNFalpha and IL1beta, two possible inducers of sphingomyelin hydrolysis, produced similar effects on hCG-stimulated testosterone production. Testosterone 116-128 interleukin 1 beta Rattus norvegicus 13-20 11146112-0 2000 Inhibition of kainic acid induced expression of interleukin-1 beta and interleukin-1 receptor antagonist mRNA in the rat brain by NMDA receptor antagonists. Kainic Acid 14-25 interleukin 1 beta Rattus norvegicus 48-66 11146112-8 2000 MK-801 at 3.0 mg/kg decreased the IL-1 beta mRNA expression, blocked or decreased the IL-1ra mRNA expression, depending on the brain region. Dizocilpine Maleate 0-6 interleukin 1 beta Rattus norvegicus 34-43 11146112-11 2000 15 min prior to the kainic acid injection abolished the IL-1 beta mRNA expression. Kainic Acid 20-31 interleukin 1 beta Rattus norvegicus 56-65 11146112-13 2000 The finding that NMDA receptor antagonists inhibit the IL-1 beta and IL-1ra mRNA synthesis induced by kainic acid suggests that NMDA receptor activation may be involved in triggering cytokine synthesis following excitotoxic brain damage. Kainic Acid 102-113 interleukin 1 beta Rattus norvegicus 55-64 11189033-6 2000 Preadministration of indomethacin (5 mg kg(-1)) 30 min before IL-1beta blocked this reduction. Indomethacin 21-33 interleukin 1 beta Rattus norvegicus 62-70 11189033-8 2000 The present results suggest that the subdiaphragmatic vagal afferents modulate the parasympathetic efferent outflow in response to IL-1beta partly through prostaglandin dependent mechanisms and that supradiaphragmatic afferents or central sites are more sensitive to the low doses of IL-1beta which becomes evident after elimination of the subdiaphragmatic vagal input. Prostaglandins 155-168 interleukin 1 beta Rattus norvegicus 131-139 11124973-3 2000 IL-1beta (10 ng/ml) treatment of rat striatal slices preloaded with (45)Ca(2+) elicited a delayed (30 min) and sustained increase (125-150%) in spontaneous (45)Ca(2+) release that was potentiated by l-arginine (300 microm) and counteracted by N-omega-nitro-l-arginine methyl ester (l-NAME) (1 and 3 mm). NG-Nitroarginine Methyl Ester 243-280 interleukin 1 beta Rattus norvegicus 0-8 11124973-3 2000 IL-1beta (10 ng/ml) treatment of rat striatal slices preloaded with (45)Ca(2+) elicited a delayed (30 min) and sustained increase (125-150%) in spontaneous (45)Ca(2+) release that was potentiated by l-arginine (300 microm) and counteracted by N-omega-nitro-l-arginine methyl ester (l-NAME) (1 and 3 mm). NG-Nitroarginine Methyl Ester 282-288 interleukin 1 beta Rattus norvegicus 0-8 11193380-5 2000 The above described facts suggest that glutamate and some sorts of cytokines (IL-1 beta and CINC-1) contribute to nociception at least from the primary afferents to the spinal dorsal horn neurons and in higher brain, respectively. Glutamic Acid 39-48 interleukin 1 beta Rattus norvegicus 78-87 11058221-1 2000 The activation of neurosecretory neurons that express corticotropin-releasing hormone (CRH) in response to increased circulating levels of interleukin-1beta (IL-1beta) depends on prostaglandin E(2) (PGE(2)) acting locally within the brain parenchyma. Dinoprostone 179-197 interleukin 1 beta Rattus norvegicus 139-156 11058221-1 2000 The activation of neurosecretory neurons that express corticotropin-releasing hormone (CRH) in response to increased circulating levels of interleukin-1beta (IL-1beta) depends on prostaglandin E(2) (PGE(2)) acting locally within the brain parenchyma. Dinoprostone 179-197 interleukin 1 beta Rattus norvegicus 158-166 11058221-1 2000 The activation of neurosecretory neurons that express corticotropin-releasing hormone (CRH) in response to increased circulating levels of interleukin-1beta (IL-1beta) depends on prostaglandin E(2) (PGE(2)) acting locally within the brain parenchyma. Prostaglandins E 199-202 interleukin 1 beta Rattus norvegicus 139-156 11058221-1 2000 The activation of neurosecretory neurons that express corticotropin-releasing hormone (CRH) in response to increased circulating levels of interleukin-1beta (IL-1beta) depends on prostaglandin E(2) (PGE(2)) acting locally within the brain parenchyma. Prostaglandins E 199-202 interleukin 1 beta Rattus norvegicus 158-166 11087273-3 2000 We have previously reported that interleukin-1beta (IL-1beta) (500 U/ml) alone induced nitric oxide (NO) production by neonatal rat cardiac myocytes (CM). Nitric Oxide 87-99 interleukin 1 beta Rattus norvegicus 33-50 11087273-3 2000 We have previously reported that interleukin-1beta (IL-1beta) (500 U/ml) alone induced nitric oxide (NO) production by neonatal rat cardiac myocytes (CM). Nitric Oxide 87-99 interleukin 1 beta Rattus norvegicus 52-60 11087273-7 2000 HIV-gp120 enhancement of IL-1beta-induced NO(2)(-) production was blocked by 10 microM of SB-203580 (SB), a selective p38 protein kinase inhibitor (3.6 +/- 0.2 vs. 6.6 +/- 0.6 micromol/1. SB 203580 90-99 interleukin 1 beta Rattus norvegicus 25-33 11087273-7 2000 HIV-gp120 enhancement of IL-1beta-induced NO(2)(-) production was blocked by 10 microM of SB-203580 (SB), a selective p38 protein kinase inhibitor (3.6 +/- 0.2 vs. 6.6 +/- 0.6 micromol/1. Antimony 90-92 interleukin 1 beta Rattus norvegicus 25-33 11132246-0 2000 High glucose enhances IL-1beta-induced cyclooxygenase-2 expression in rat vascular smooth muscle cells. Glucose 5-12 interleukin 1 beta Rattus norvegicus 22-30 11132246-3 2000 In this study, we investigated the effect of high glucose on IL-1beta-induced PG production and the possible underlying mechanism in cultured vascular smooth muscle cell (VSMC). Glucose 50-57 interleukin 1 beta Rattus norvegicus 61-69 11132246-3 2000 In this study, we investigated the effect of high glucose on IL-1beta-induced PG production and the possible underlying mechanism in cultured vascular smooth muscle cell (VSMC). Prostaglandins 78-80 interleukin 1 beta Rattus norvegicus 61-69 11132246-4 2000 High glucose evoked an augmentation of IL-1beta-induced PG synthesis in a dose dependent manner and enhanced cyclooxygenase (COX) activity, which reached to maximum at 8-12 hours after stimulation. Glucose 5-12 interleukin 1 beta Rattus norvegicus 39-47 11132246-4 2000 High glucose evoked an augmentation of IL-1beta-induced PG synthesis in a dose dependent manner and enhanced cyclooxygenase (COX) activity, which reached to maximum at 8-12 hours after stimulation. Prostaglandins 56-58 interleukin 1 beta Rattus norvegicus 39-47 11132246-6 2000 Protein kinase C (PKC) inhibitors, H-7 and chelerythrine, significantly inhibited the enhancement of IL-1beta-induced COX-2 expression by high glucose. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 35-38 interleukin 1 beta Rattus norvegicus 101-109 11132246-6 2000 Protein kinase C (PKC) inhibitors, H-7 and chelerythrine, significantly inhibited the enhancement of IL-1beta-induced COX-2 expression by high glucose. chelerythrine 43-56 interleukin 1 beta Rattus norvegicus 101-109 11132246-6 2000 Protein kinase C (PKC) inhibitors, H-7 and chelerythrine, significantly inhibited the enhancement of IL-1beta-induced COX-2 expression by high glucose. Glucose 143-150 interleukin 1 beta Rattus norvegicus 101-109 11087233-3 2000 Because interleukin (IL)-1beta may activate nitric oxide in the brain, we have tested the hypothesis that IL-1beta may modulate the activity of the SNS via regulation of the local expression of neuronal NOS (nNOS) in the brain of CRF and control rats. Nitric Oxide 44-56 interleukin 1 beta Rattus norvegicus 8-30 11087233-3 2000 Because interleukin (IL)-1beta may activate nitric oxide in the brain, we have tested the hypothesis that IL-1beta may modulate the activity of the SNS via regulation of the local expression of neuronal NOS (nNOS) in the brain of CRF and control rats. Nitric Oxide 44-56 interleukin 1 beta Rattus norvegicus 106-114 11087233-4 2000 To this end, we first found that administration of IL-1beta in the lateral ventricle of control and CRF rats decreased blood pressure and norepinephrine (NE) secretion from the posterior hypothalamus (PH) and increased NOS mRNA expression. Norepinephrine 138-152 interleukin 1 beta Rattus norvegicus 51-59 11191283-0 2000 The acid sphingomyelinase inhibitor SR33557 counteracts TNF-alpha-mediated potentiation of IL-1beta-induced NF-kappaB activation in the insulin-producing cell line Rinm5F. fantofarone 36-43 interleukin 1 beta Rattus norvegicus 91-99 11191283-6 2000 However, both ceramide and TNF-alpha potentiated IL-1beta- induced activation of NF-kappaB and iNOS. Ceramides 14-22 interleukin 1 beta Rattus norvegicus 49-57 11151765-4 2000 METHODS/RESULTS: Cells exposed to high D-glucose (30 mmol/l) caused an increase in [3H]-thymidine incorporation and cell numbers at 24 and 48 h and normalized at 72 h (p < 0.05), whereas these changes were not found in high mannitol (30 mmol/l), IL-1 beta, or TNF alpha-stimulated mesangial cells. Glucose 39-48 interleukin 1 beta Rattus norvegicus 249-258 11151765-6 2000 The stimulatory effects of high glucose and high mannitol on mRNA expression were observed as early as 6 h and reached its maximum at 12 h. Up-regulation of ICAM-1 protein and mRNA was also found in IL-1-beta and TNF-alpha-stimulated mesangial cells. Glucose 32-39 interleukin 1 beta Rattus norvegicus 199-208 11151765-6 2000 The stimulatory effects of high glucose and high mannitol on mRNA expression were observed as early as 6 h and reached its maximum at 12 h. Up-regulation of ICAM-1 protein and mRNA was also found in IL-1-beta and TNF-alpha-stimulated mesangial cells. Mannitol 49-57 interleukin 1 beta Rattus norvegicus 199-208 11093787-3 2000 Simultaneous incubation of cells with isoproterenol enhances the response to IL-1beta, even though isoproterenol alone is without effect. Isoproterenol 38-51 interleukin 1 beta Rattus norvegicus 77-85 11093787-3 2000 Simultaneous incubation of cells with isoproterenol enhances the response to IL-1beta, even though isoproterenol alone is without effect. Isoproterenol 99-112 interleukin 1 beta Rattus norvegicus 77-85 11093787-4 2000 N(G)-nitro-L-arginine methyl ester inhibits the effect of isoproterenol + IL-1beta on NO production. NG-Nitroarginine Methyl Ester 0-34 interleukin 1 beta Rattus norvegicus 74-82 11093787-7 2000 Dibutyryl-cyclic AMP and forskolin mimic the synergistic effect of isoproterenol on IL-1beta-induced NO production; H-89, a cyclic AMP-dependent protein kinase (PKA) inhibitor, antagonizes the enhancing effect of isoproterenol. Bucladesine 0-20 interleukin 1 beta Rattus norvegicus 84-92 11093787-7 2000 Dibutyryl-cyclic AMP and forskolin mimic the synergistic effect of isoproterenol on IL-1beta-induced NO production; H-89, a cyclic AMP-dependent protein kinase (PKA) inhibitor, antagonizes the enhancing effect of isoproterenol. Colforsin 25-34 interleukin 1 beta Rattus norvegicus 84-92 11093787-7 2000 Dibutyryl-cyclic AMP and forskolin mimic the synergistic effect of isoproterenol on IL-1beta-induced NO production; H-89, a cyclic AMP-dependent protein kinase (PKA) inhibitor, antagonizes the enhancing effect of isoproterenol. Isoproterenol 67-80 interleukin 1 beta Rattus norvegicus 84-92 11093787-7 2000 Dibutyryl-cyclic AMP and forskolin mimic the synergistic effect of isoproterenol on IL-1beta-induced NO production; H-89, a cyclic AMP-dependent protein kinase (PKA) inhibitor, antagonizes the enhancing effect of isoproterenol. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 116-120 interleukin 1 beta Rattus norvegicus 84-92 11093787-7 2000 Dibutyryl-cyclic AMP and forskolin mimic the synergistic effect of isoproterenol on IL-1beta-induced NO production; H-89, a cyclic AMP-dependent protein kinase (PKA) inhibitor, antagonizes the enhancing effect of isoproterenol. Isoproterenol 213-226 interleukin 1 beta Rattus norvegicus 84-92 11132246-9 2000 These results suggest that the augmenting effect of high glucose on IL-1beta-induced PG production and COX-2 expression is, at least in part, due to increased glucose metabolism via sorbitol pathway following PKC activation. Glucose 57-64 interleukin 1 beta Rattus norvegicus 68-76 11132246-9 2000 These results suggest that the augmenting effect of high glucose on IL-1beta-induced PG production and COX-2 expression is, at least in part, due to increased glucose metabolism via sorbitol pathway following PKC activation. Prostaglandins 85-87 interleukin 1 beta Rattus norvegicus 68-76 11132246-9 2000 These results suggest that the augmenting effect of high glucose on IL-1beta-induced PG production and COX-2 expression is, at least in part, due to increased glucose metabolism via sorbitol pathway following PKC activation. Glucose 159-166 interleukin 1 beta Rattus norvegicus 68-76 11132246-9 2000 These results suggest that the augmenting effect of high glucose on IL-1beta-induced PG production and COX-2 expression is, at least in part, due to increased glucose metabolism via sorbitol pathway following PKC activation. Sorbitol 182-190 interleukin 1 beta Rattus norvegicus 68-76 11067938-3 2000 Here we report that exogenously administrated superoxide, generated by the hypoxanthine/xanthine oxidase system (HXXO) or by the redox cycler 2, 3-dimethoxy-1,4-naphtoquinone, caused a marked amplification of IL-1beta-primed, steady state, MMP-9 mRNA level and an increase in gelatinolytic activity in the conditioned medium. Superoxides 46-56 interleukin 1 beta Rattus norvegicus 209-217 11067938-3 2000 Here we report that exogenously administrated superoxide, generated by the hypoxanthine/xanthine oxidase system (HXXO) or by the redox cycler 2, 3-dimethoxy-1,4-naphtoquinone, caused a marked amplification of IL-1beta-primed, steady state, MMP-9 mRNA level and an increase in gelatinolytic activity in the conditioned medium. 2, 3-dimethoxy-1,4-naphtoquinone 142-174 interleukin 1 beta Rattus norvegicus 209-217 11067938-10 2000 Furthermore, IL-1beta-triggered phosphorylation of all three MAPKs, including p38-MAPK, c-Jun N-terminal kinase, and ERK, was substantially enhanced by superoxide. Superoxides 152-162 interleukin 1 beta Rattus norvegicus 13-21 11126408-2 2000 Mitogen-activated protein kinase (MAPK) activity that is induced by interleukin-1 beta has been suggested to signal nitric oxide-dependent as well as nitric oxide-independent beta-cell destructive pathways. Nitric Oxide 116-128 interleukin 1 beta Rattus norvegicus 68-86 11078448-4 2000 IL-1beta-induced NO production was prevented by incubation of islets in arginine-free medium supplemented with the arginine analog NG-nitro-L-arginine. Arginine 115-123 interleukin 1 beta Rattus norvegicus 0-8 11078448-4 2000 IL-1beta-induced NO production was prevented by incubation of islets in arginine-free medium supplemented with the arginine analog NG-nitro-L-arginine. Nitroarginine 131-150 interleukin 1 beta Rattus norvegicus 0-8 11078448-2 2000 Nitric oxide (NO) has been implicated as one of the mediators of IL-1beta effects in insulin-containing cell lines and rat islets. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 65-73 11078448-4 2000 IL-1beta-induced NO production was prevented by incubation of islets in arginine-free medium supplemented with the arginine analog NG-nitro-L-arginine. Arginine 72-80 interleukin 1 beta Rattus norvegicus 0-8 11126408-2 2000 Mitogen-activated protein kinase (MAPK) activity that is induced by interleukin-1 beta has been suggested to signal nitric oxide-dependent as well as nitric oxide-independent beta-cell destructive pathways. Nitric Oxide 150-162 interleukin 1 beta Rattus norvegicus 68-86 11153597-1 2000 SB 203580 is a pyridinyl imidazole compound which inhibits the release of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), in vitro and in vivo by inhibiting p38 mitogen-activated protein kinase (MAPK). SB 203580 0-9 interleukin 1 beta Rattus norvegicus 155-172 11153597-1 2000 SB 203580 is a pyridinyl imidazole compound which inhibits the release of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), in vitro and in vivo by inhibiting p38 mitogen-activated protein kinase (MAPK). SB 203580 0-9 interleukin 1 beta Rattus norvegicus 174-182 11050054-3 2000 Pro-inflammatory cytokines including interleukin 1beta (IL-1beta) induce a gene expression of inducible nitric oxide synthase (iNOS) and produce nitric oxide, which exerts either a cytoprotective or toxic effect. Nitric Oxide 104-116 interleukin 1 beta Rattus norvegicus 37-54 11050054-3 2000 Pro-inflammatory cytokines including interleukin 1beta (IL-1beta) induce a gene expression of inducible nitric oxide synthase (iNOS) and produce nitric oxide, which exerts either a cytoprotective or toxic effect. Nitric Oxide 104-116 interleukin 1 beta Rattus norvegicus 56-64 11050054-4 2000 In this report, we found that hypoxia and heat markedly inhibited the induction of nitric oxide production stimulated by IL-1beta in rat cultured hepatocytes. Nitric Oxide 83-95 interleukin 1 beta Rattus norvegicus 121-129 11153597-1 2000 SB 203580 is a pyridinyl imidazole compound which inhibits the release of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), in vitro and in vivo by inhibiting p38 mitogen-activated protein kinase (MAPK). 2-(1H-imidazol-2-yl)pyridine 15-34 interleukin 1 beta Rattus norvegicus 155-172 11153597-1 2000 SB 203580 is a pyridinyl imidazole compound which inhibits the release of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), in vitro and in vivo by inhibiting p38 mitogen-activated protein kinase (MAPK). 2-(1H-imidazol-2-yl)pyridine 15-34 interleukin 1 beta Rattus norvegicus 174-182 10998358-4 2000 Kinetic analysis of the products present in rat chondrosarcoma cell cultures treated with interleukin-1b showed that the first aggrecanase-mediated cleavages occurred at the four sites within the CS attachment region to generate two stable intermediates, Val(1)-Glu(1459) and Val(1)-Glu(1274). val(1)-glu 276-286 interleukin 1 beta Rattus norvegicus 90-104 11131279-5 2000 Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A). Nitrites 0-7 interleukin 1 beta Rattus norvegicus 47-69 11131279-5 2000 Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A). Nitrates 8-15 interleukin 1 beta Rattus norvegicus 47-69 11131279-5 2000 Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A). nicotine 1-N-oxide 17-20 interleukin 1 beta Rattus norvegicus 47-69 11131279-5 2000 Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 235-242 interleukin 1 beta Rattus norvegicus 47-69 11105912-0 2000 Interleukin-1beta regulates nitric oxide production and gamma-glutamyl transpeptidase activity in sertoli cells. Nitric Oxide 28-40 interleukin 1 beta Rattus norvegicus 0-17 11105912-6 2000 Therefore, we investigated whether IL1beta modified the level of nitrite, a stable metabolite of NO, in Sertoli cells. Nitrites 65-72 interleukin 1 beta Rattus norvegicus 35-42 11105912-7 2000 Dose-response curves to IL1beta for gammaGTP activity and nitrite production were observed. Nitrites 58-65 interleukin 1 beta Rattus norvegicus 24-31 11050138-3 2000 Four hours after injection of IL-1beta (1 ng in 1 microliter), cerebral blood volume was significantly increased, the blood-brain barrier (BBB) became permeable to intravenously administered contrast agent between 4.5 and 5 hr, and the apparent diffusion coefficient (ADC) of brain water fell by 6 hr (5.42 +/- 0. Water 282-287 interleukin 1 beta Rattus norvegicus 30-38 11050138-9 2000 The presence of neutrophils within the brain parenchyma significantly contributed to the IL-1beta-induced changes in cerebral blood volume and the ADC of brain water. Water 160-165 interleukin 1 beta Rattus norvegicus 89-97 11032727-2 2000 IL-1beta seems to act chiefly through induction of nitric oxide (NO) synthesis. Nitric Oxide 51-63 interleukin 1 beta Rattus norvegicus 0-8 11032727-7 2000 It was found that cell proliferation, viability, insulin production and the stimulation of insulin release evoked by carbamylcholine and phorbol ester were impeded by IL-1beta or spermine-NONOate, whereas the hormone output by the other secretagogues was not altered by NO. Carbachol 117-132 interleukin 1 beta Rattus norvegicus 167-175 11032727-7 2000 It was found that cell proliferation, viability, insulin production and the stimulation of insulin release evoked by carbamylcholine and phorbol ester were impeded by IL-1beta or spermine-NONOate, whereas the hormone output by the other secretagogues was not altered by NO. Phorbol Esters 137-150 interleukin 1 beta Rattus norvegicus 167-175 11032727-8 2000 Pretreatment with gamma-tocopherol (but not alpha-tocopherol) afforded a partial protection against the inhibitory effects of NO, whereas specifically inhibiting inducible NO synthase with N-nitro-L-arginine completely reversed the IL-1beta effects. gamma-Tocopherol 18-34 interleukin 1 beta Rattus norvegicus 232-240 11032727-8 2000 Pretreatment with gamma-tocopherol (but not alpha-tocopherol) afforded a partial protection against the inhibitory effects of NO, whereas specifically inhibiting inducible NO synthase with N-nitro-L-arginine completely reversed the IL-1beta effects. Nitroarginine 189-207 interleukin 1 beta Rattus norvegicus 232-240 11501043-0 2000 Effect of ginsenoside on IL-1 beta and IL-6 mRNA expression in hippocampal neurons in chronic inflammation model of aged rats. Ginsenosides 10-21 interleukin 1 beta Rattus norvegicus 25-34 11501043-1 2000 AIM: To study the effects of ginseng root saponins (GRS) on interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) expression in hippocampal neurons in chronic inflammation model of aged rats. Saponins 42-50 interleukin 1 beta Rattus norvegicus 80-89 10998358-4 2000 Kinetic analysis of the products present in rat chondrosarcoma cell cultures treated with interleukin-1b showed that the first aggrecanase-mediated cleavages occurred at the four sites within the CS attachment region to generate two stable intermediates, Val(1)-Glu(1459) and Val(1)-Glu(1274). Chondroitin Sulfates 196-198 interleukin 1 beta Rattus norvegicus 90-104 10998358-4 2000 Kinetic analysis of the products present in rat chondrosarcoma cell cultures treated with interleukin-1b showed that the first aggrecanase-mediated cleavages occurred at the four sites within the CS attachment region to generate two stable intermediates, Val(1)-Glu(1459) and Val(1)-Glu(1274). val(1)-glu 255-265 interleukin 1 beta Rattus norvegicus 90-104 10996220-7 2000 Pretreatment with MK-801 strongly inhibited remote cytokine expression (mean reduction by 80% relative to vehicle treated animals at 4 h; P<0.001) whereas in the lesions only partial reductions in the expression of IL-1beta and iNOS mRNA were found. Dizocilpine Maleate 18-24 interleukin 1 beta Rattus norvegicus 218-226 11003621-9 2000 The NOS inhibitor N(G)-monomethyl-L-arginine (NMA) inhibited the protective effects of IL-1beta and IFN-gamma. omega-N-Methylarginine 18-44 interleukin 1 beta Rattus norvegicus 87-95 11003621-9 2000 The NOS inhibitor N(G)-monomethyl-L-arginine (NMA) inhibited the protective effects of IL-1beta and IFN-gamma. omega-N-Methylarginine 46-49 interleukin 1 beta Rattus norvegicus 87-95 11045388-6 2000 The increase in calcium-independent NOS activity correlated with a high plasma concentration of interleukin-1beta in the ricin plus lipopolysaccharide group (4,036.83+/-1,001.5 pg/ml). Calcium 16-23 interleukin 1 beta Rattus norvegicus 96-113 11894876-0 2000 [Changes of mRNA expression of IL-1beta and TNF-alpha in rat brains after repeated exposures to +Gz]. gz 97-99 interleukin 1 beta Rattus norvegicus 31-39 11894876-2 2000 To study changes of mRNA expression of IL-1beta and TNF-alpha in rat brains after repeated exposures to +Gz. gz 105-107 interleukin 1 beta Rattus norvegicus 39-47 11894876-10 2000 mRNA expression levels of IL-1beta and TNF-alpha in rat brains taken 30 min, 6 h and 24 h after repeated +Gz exposures were significantly higher than those in control rats, but returned to normal after 48 h. Conclusion. gz 106-108 interleukin 1 beta Rattus norvegicus 26-34 11894876-11 2000 It suggested that mRNA expressions of IL-1beta and TNF-alpha in rat brains can be stimulated by repeated +Gz exposures and the increased expression of IL-1beta and TNF-alpha may play a role in the pathologic course of brain damage induced by +Gz exposures, but the damage is reversible. gz 106-108 interleukin 1 beta Rattus norvegicus 38-46 11043903-1 2000 Striatal coadministration of interleukin-1beta (IL-1beta) with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (S-AMPA) in rats results in widespread cortical cell death not caused by either treatment alone. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate 63-115 interleukin 1 beta Rattus norvegicus 29-46 11043903-1 2000 Striatal coadministration of interleukin-1beta (IL-1beta) with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (S-AMPA) in rats results in widespread cortical cell death not caused by either treatment alone. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate 63-115 interleukin 1 beta Rattus norvegicus 48-56 11043903-1 2000 Striatal coadministration of interleukin-1beta (IL-1beta) with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (S-AMPA) in rats results in widespread cortical cell death not caused by either treatment alone. alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid 117-123 interleukin 1 beta Rattus norvegicus 29-46 11027530-3 2000 Sodium butyrate (NaBu) and Trichostatin A (TSA) induced alkaline phosphatase activity and histone H4 acetylation in IEC-6 rat intestinal epithelial cells treated with or without interleukin-1beta (IL-1). Butyric Acid 0-15 interleukin 1 beta Rattus norvegicus 178-195 11027530-3 2000 Sodium butyrate (NaBu) and Trichostatin A (TSA) induced alkaline phosphatase activity and histone H4 acetylation in IEC-6 rat intestinal epithelial cells treated with or without interleukin-1beta (IL-1). sethoxydim 17-21 interleukin 1 beta Rattus norvegicus 178-195 11027530-3 2000 Sodium butyrate (NaBu) and Trichostatin A (TSA) induced alkaline phosphatase activity and histone H4 acetylation in IEC-6 rat intestinal epithelial cells treated with or without interleukin-1beta (IL-1). trichostatin A 27-41 interleukin 1 beta Rattus norvegicus 178-195 11027530-3 2000 Sodium butyrate (NaBu) and Trichostatin A (TSA) induced alkaline phosphatase activity and histone H4 acetylation in IEC-6 rat intestinal epithelial cells treated with or without interleukin-1beta (IL-1). trichostatin A 43-46 interleukin 1 beta Rattus norvegicus 178-195 10995825-3 2000 In this study, we have investigated the downstream consequences of an increase in IL-1beta concentration and report that the reduced LTP in rats injected intracerebroventricularly with IL-1beta was accompanied by a decrease in KCl-stimulated glutamate release in synaptosomes prepared from dentate gyrus, although unstimulated glutamate release was increased. Potassium Chloride 227-230 interleukin 1 beta Rattus norvegicus 82-90 10995825-3 2000 In this study, we have investigated the downstream consequences of an increase in IL-1beta concentration and report that the reduced LTP in rats injected intracerebroventricularly with IL-1beta was accompanied by a decrease in KCl-stimulated glutamate release in synaptosomes prepared from dentate gyrus, although unstimulated glutamate release was increased. Potassium Chloride 227-230 interleukin 1 beta Rattus norvegicus 185-193 10995825-3 2000 In this study, we have investigated the downstream consequences of an increase in IL-1beta concentration and report that the reduced LTP in rats injected intracerebroventricularly with IL-1beta was accompanied by a decrease in KCl-stimulated glutamate release in synaptosomes prepared from dentate gyrus, although unstimulated glutamate release was increased. Glutamic Acid 242-251 interleukin 1 beta Rattus norvegicus 82-90 10995825-3 2000 In this study, we have investigated the downstream consequences of an increase in IL-1beta concentration and report that the reduced LTP in rats injected intracerebroventricularly with IL-1beta was accompanied by a decrease in KCl-stimulated glutamate release in synaptosomes prepared from dentate gyrus, although unstimulated glutamate release was increased. Glutamic Acid 242-251 interleukin 1 beta Rattus norvegicus 185-193 10995825-3 2000 In this study, we have investigated the downstream consequences of an increase in IL-1beta concentration and report that the reduced LTP in rats injected intracerebroventricularly with IL-1beta was accompanied by a decrease in KCl-stimulated glutamate release in synaptosomes prepared from dentate gyrus, although unstimulated glutamate release was increased. Glutamic Acid 327-336 interleukin 1 beta Rattus norvegicus 82-90 10995825-3 2000 In this study, we have investigated the downstream consequences of an increase in IL-1beta concentration and report that the reduced LTP in rats injected intracerebroventricularly with IL-1beta was accompanied by a decrease in KCl-stimulated glutamate release in synaptosomes prepared from dentate gyrus, although unstimulated glutamate release was increased. Glutamic Acid 327-336 interleukin 1 beta Rattus norvegicus 185-193 10995825-5 2000 Intracerebroventricular injection of IL-1beta increased reactive oxygen species production in hippocampal tissue, whereas IL-1beta and H(2)O(2) increased activities of both JNK and p38 in vitro. Reactive Oxygen Species 56-79 interleukin 1 beta Rattus norvegicus 37-45 10995825-7 2000 We propose that IL-1beta stimulates activity of stress-activated kinases, which in turn may inhibit glutamate release and result in compromised LTP and that these actions are a consequence of increased production of reactive oxygen species. Glutamic Acid 100-109 interleukin 1 beta Rattus norvegicus 16-24 10995825-7 2000 We propose that IL-1beta stimulates activity of stress-activated kinases, which in turn may inhibit glutamate release and result in compromised LTP and that these actions are a consequence of increased production of reactive oxygen species. Reactive Oxygen Species 216-239 interleukin 1 beta Rattus norvegicus 16-24 10976000-0 2000 Glutathione depletion inhibits IL-1 beta-stimulated nitric oxide production by reducing inducible nitric oxide synthase gene expression. Glutathione 0-11 interleukin 1 beta Rattus norvegicus 31-40 10991908-2 2000 The p38 kinase inhibitor, SB 203580 inhibits TNF-alpha and IL-1beta production in vitro and in vivo. SB 203580 26-35 interleukin 1 beta Rattus norvegicus 59-67 10976000-0 2000 Glutathione depletion inhibits IL-1 beta-stimulated nitric oxide production by reducing inducible nitric oxide synthase gene expression. Nitric Oxide 52-64 interleukin 1 beta Rattus norvegicus 31-40 10976000-2 2000 The thiol depletor diethyl maleate (DEM) and an inhibitor of glutathione reductase 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) reduced IL-1 beta-stimulated nitrite release in islets. Carmustine 121-125 interleukin 1 beta Rattus norvegicus 135-144 10976000-1 2000 L-buthionine-S,R-sulfoximine (BSO), an inhibitor of GSH synthesis, decreased IL-1 beta-induced nitrite release in rat islets and purified rat beta cells, nitrite formation and iNOS gene promoter activity in insulinoma cells, and iNOS mRNA expression in rat islets. l-buthionine-s 0-14 interleukin 1 beta Rattus norvegicus 77-86 10976000-2 2000 The thiol depletor diethyl maleate (DEM) and an inhibitor of glutathione reductase 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) reduced IL-1 beta-stimulated nitrite release in islets. Nitrites 156-163 interleukin 1 beta Rattus norvegicus 135-144 10976000-3 2000 We conclude that GSH regulates IL-1 beta-induced NO production in islets, purified beta cells and insulinoma cells by modulation of iNOS gene expression. Glutathione 17-20 interleukin 1 beta Rattus norvegicus 31-40 10976000-1 2000 L-buthionine-S,R-sulfoximine (BSO), an inhibitor of GSH synthesis, decreased IL-1 beta-induced nitrite release in rat islets and purified rat beta cells, nitrite formation and iNOS gene promoter activity in insulinoma cells, and iNOS mRNA expression in rat islets. r-sulfoximine 15-28 interleukin 1 beta Rattus norvegicus 77-86 10976000-1 2000 L-buthionine-S,R-sulfoximine (BSO), an inhibitor of GSH synthesis, decreased IL-1 beta-induced nitrite release in rat islets and purified rat beta cells, nitrite formation and iNOS gene promoter activity in insulinoma cells, and iNOS mRNA expression in rat islets. Buthionine Sulfoximine 30-33 interleukin 1 beta Rattus norvegicus 77-86 10976000-1 2000 L-buthionine-S,R-sulfoximine (BSO), an inhibitor of GSH synthesis, decreased IL-1 beta-induced nitrite release in rat islets and purified rat beta cells, nitrite formation and iNOS gene promoter activity in insulinoma cells, and iNOS mRNA expression in rat islets. Glutathione 52-55 interleukin 1 beta Rattus norvegicus 77-86 10976000-1 2000 L-buthionine-S,R-sulfoximine (BSO), an inhibitor of GSH synthesis, decreased IL-1 beta-induced nitrite release in rat islets and purified rat beta cells, nitrite formation and iNOS gene promoter activity in insulinoma cells, and iNOS mRNA expression in rat islets. Nitrites 95-102 interleukin 1 beta Rattus norvegicus 77-86 10976000-2 2000 The thiol depletor diethyl maleate (DEM) and an inhibitor of glutathione reductase 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) reduced IL-1 beta-stimulated nitrite release in islets. Sulfhydryl Compounds 4-9 interleukin 1 beta Rattus norvegicus 135-144 10976000-2 2000 The thiol depletor diethyl maleate (DEM) and an inhibitor of glutathione reductase 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) reduced IL-1 beta-stimulated nitrite release in islets. diethyl maleate 19-34 interleukin 1 beta Rattus norvegicus 135-144 10976000-2 2000 The thiol depletor diethyl maleate (DEM) and an inhibitor of glutathione reductase 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) reduced IL-1 beta-stimulated nitrite release in islets. diethyl maleate 36-39 interleukin 1 beta Rattus norvegicus 135-144 10976000-2 2000 The thiol depletor diethyl maleate (DEM) and an inhibitor of glutathione reductase 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) reduced IL-1 beta-stimulated nitrite release in islets. 3-bis(2-chloroethyl)-1-nitrosourea 85-119 interleukin 1 beta Rattus norvegicus 135-144 11016861-4 2000 NO2- production stimulated by IL-1beta + TGFalpha was significantly reduced by N(G)-nitro-L-arginine methyl ester (L-NAME) or aminoguanidine, yet not by D-NAME. pimagedine 126-140 interleukin 1 beta Rattus norvegicus 30-38 11071122-8 2000 Whereas both dexamethasone and indomethacin were effective in reducing interleukin- (IL) 1beta-induced fever, only dexamethasone abolished the fever induced by PFPF. Dexamethasone 13-26 interleukin 1 beta Rattus norvegicus 71-94 11071122-8 2000 Whereas both dexamethasone and indomethacin were effective in reducing interleukin- (IL) 1beta-induced fever, only dexamethasone abolished the fever induced by PFPF. Indomethacin 31-43 interleukin 1 beta Rattus norvegicus 71-94 11045663-9 2000 The optimal doses of CsA and tacrolimus had similar inhibitory effects on Th1 type cytokine IL-2 and interferon [INF]-gamma), inflammatory cytokine (IL-1beta and tumor necrosis factor [TNF]-alpha), and cytotoxic factor (granzyme B and perforin) mRNA expression. Cyclosporine 21-24 interleukin 1 beta Rattus norvegicus 149-157 11045663-9 2000 The optimal doses of CsA and tacrolimus had similar inhibitory effects on Th1 type cytokine IL-2 and interferon [INF]-gamma), inflammatory cytokine (IL-1beta and tumor necrosis factor [TNF]-alpha), and cytotoxic factor (granzyme B and perforin) mRNA expression. Tacrolimus 29-39 interleukin 1 beta Rattus norvegicus 149-157 11016861-4 2000 NO2- production stimulated by IL-1beta + TGFalpha was significantly reduced by N(G)-nitro-L-arginine methyl ester (L-NAME) or aminoguanidine, yet not by D-NAME. Nitrogen Dioxide 0-3 interleukin 1 beta Rattus norvegicus 30-38 11016864-6 2000 In capsaicin-treated group of rats, we observed the increase in PBF by 44% and in serum Il-1beta concentration by 91%. Capsaicin 3-12 interleukin 1 beta Rattus norvegicus 88-96 11016861-4 2000 NO2- production stimulated by IL-1beta + TGFalpha was significantly reduced by N(G)-nitro-L-arginine methyl ester (L-NAME) or aminoguanidine, yet not by D-NAME. NG-Nitroarginine Methyl Ester 79-113 interleukin 1 beta Rattus norvegicus 30-38 11016861-4 2000 NO2- production stimulated by IL-1beta + TGFalpha was significantly reduced by N(G)-nitro-L-arginine methyl ester (L-NAME) or aminoguanidine, yet not by D-NAME. NG-Nitroarginine Methyl Ester 115-121 interleukin 1 beta Rattus norvegicus 30-38 11035283-10 2000 Treatment with indomethacin (10 microg/mL), an established inhibitor of prostaglandin biosynthesis, resulted in a significant (P <.05) decrease (79%) in the ability of IL-1 beta to up-regulate IL-6 transcripts. Indomethacin 15-27 interleukin 1 beta Rattus norvegicus 171-180 11035283-10 2000 Treatment with indomethacin (10 microg/mL), an established inhibitor of prostaglandin biosynthesis, resulted in a significant (P <.05) decrease (79%) in the ability of IL-1 beta to up-regulate IL-6 transcripts. Prostaglandins 72-85 interleukin 1 beta Rattus norvegicus 171-180 11035283-11 2000 Importantly, the addition of prostaglandin E(2) (10 microg/mL) to untreated or indomethacin-treated cells significantly (P <.05) augmented the IL-1 beta effect. Dinoprostone 29-47 interleukin 1 beta Rattus norvegicus 146-155 11035283-11 2000 Importantly, the addition of prostaglandin E(2) (10 microg/mL) to untreated or indomethacin-treated cells significantly (P <.05) augmented the IL-1 beta effect. Indomethacin 79-91 interleukin 1 beta Rattus norvegicus 146-155 10963751-0 2000 Nitric oxide regulates body temperature, neuronal activation and interleukin-1 beta gene expression in the hypothalamic paraventricular nucleus in response to immune stress. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 65-83 11035283-12 2000 This suggests a role for eicosanoid signaling in IL-1 beta action. Eicosanoids 25-35 interleukin 1 beta Rattus norvegicus 49-58 11035283-13 2000 Treatment with aminoguanidine, an established inhibitor of nitric oxide synthase, significantly (P <.05) decreased (85%) the IL-1 beta effect. pimagedine 15-29 interleukin 1 beta Rattus norvegicus 128-137 10963751-5 2000 Finally, increased IL-1 beta gene expression in the PVN of LPS-treated rats receiving N(G)-nitro-L-arginine showed that NO regulates brain IL-1 beta gene expression. Nitroarginine 86-107 interleukin 1 beta Rattus norvegicus 19-28 10963751-5 2000 Finally, increased IL-1 beta gene expression in the PVN of LPS-treated rats receiving N(G)-nitro-L-arginine showed that NO regulates brain IL-1 beta gene expression. Nitroarginine 86-107 interleukin 1 beta Rattus norvegicus 139-148 10924055-5 2000 The sarcoma virus tyrosine kinase (Src) family-selective inhibitor 4-amino-5(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP1) blocked the upregulation of IL-1beta mRNA and the subsequent induction of iNOS but not the induction of iNOS stimulated by exogenously added IL-1beta. 4-amino-5(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine 67-129 interleukin 1 beta Rattus norvegicus 277-285 10924055-5 2000 The sarcoma virus tyrosine kinase (Src) family-selective inhibitor 4-amino-5(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP1) blocked the upregulation of IL-1beta mRNA and the subsequent induction of iNOS but not the induction of iNOS stimulated by exogenously added IL-1beta. PP1 131-134 interleukin 1 beta Rattus norvegicus 164-172 10924055-5 2000 The sarcoma virus tyrosine kinase (Src) family-selective inhibitor 4-amino-5(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP1) blocked the upregulation of IL-1beta mRNA and the subsequent induction of iNOS but not the induction of iNOS stimulated by exogenously added IL-1beta. 4-amino-5(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine 67-129 interleukin 1 beta Rattus norvegicus 164-172 10924055-5 2000 The sarcoma virus tyrosine kinase (Src) family-selective inhibitor 4-amino-5(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP1) blocked the upregulation of IL-1beta mRNA and the subsequent induction of iNOS but not the induction of iNOS stimulated by exogenously added IL-1beta. PP1 131-134 interleukin 1 beta Rattus norvegicus 277-285 10924055-6 2000 In contrast, the non-Src inhibitors TP 47/AG 213 and genistein and the tyrosine phosphatase inhibitor vanadate did not affect the spontaneous upregulation of IL-1beta mRNA but blocked both the IL-1beta-mediated and spontaneous induction of iNOS. Vanadates 102-110 interleukin 1 beta Rattus norvegicus 193-201 10990075-10 2000 Cyclophosphamide treatment decreased IL-12, IL-1beta, IL-2, IFN-gamma and TNF-alpha gene expressions in mononuclear spleen cells but IL-4 gene expression increased. Cyclophosphamide 0-16 interleukin 1 beta Rattus norvegicus 44-52 10930305-2 2000 Exposure to crocidolite increased production of tumour necrosis factor-alpha (TNF-alpha) and interleukin 1beta (IL-1beta), whereas exposure to chrysotile did not; neither fibre altered the production of interleukin 6 (IL-6). Asbestos, Crocidolite 12-23 interleukin 1 beta Rattus norvegicus 93-110 10930305-2 2000 Exposure to crocidolite increased production of tumour necrosis factor-alpha (TNF-alpha) and interleukin 1beta (IL-1beta), whereas exposure to chrysotile did not; neither fibre altered the production of interleukin 6 (IL-6). Asbestos, Crocidolite 12-23 interleukin 1 beta Rattus norvegicus 112-120 10930315-0 2000 Synthesis of interleukin 1beta and interleukin 6 by stimulated rat peritoneal macrophages: modulation by glutamine. Glutamine 105-114 interleukin 1 beta Rattus norvegicus 13-30 10930315-4 2000 Glutamine addition increased the synthesis of both cytokines, but the overall production (intra-+extracellular) of IL-1beta increased two-fold, although that of IL-6 increased only 1.3-fold. Glutamine 0-9 interleukin 1 beta Rattus norvegicus 115-123 10950380-11 2000 At 24 hours reperfusion, carvedilol decreased TNF-alpha and IL-1beta expression by 40% to 50% in the ipsilateral ischemic cortex compared with the contralateral controls. Carvedilol 25-35 interleukin 1 beta Rattus norvegicus 60-68 10950380-12 2000 The results of the current study indicate that carvedilol is neuroprotective in focal cerebral ischemia and may protect the ischemic brain by inhibiting apoptosis and attenuating the expression of TNF-alpha and IL-1beta. Carvedilol 47-57 interleukin 1 beta Rattus norvegicus 211-219 10953999-9 2000 Treatment with IL-1beta reduced the AGEs-stimulated intracellular oxidant level through increased NO production, whilst inhibition of NO production by L-NMMA reduced the inhibitory effect of IL-1beta. omega-N-Methylarginine 151-157 interleukin 1 beta Rattus norvegicus 191-199 10953999-11 2000 We also confirmed that total GSH levels, decreased by AGEs, were restored by stimulation with IL-1beta. Glutathione 29-32 interleukin 1 beta Rattus norvegicus 94-102 10919268-8 2000 NG-methyl-L-arginine (LMA), a blocker of the inducible form of nitric oxide synthase (iNOS), prevented this late inhibitory effect of IL-1beta, suggesting that IL-1beta-induced decrease in PLD1a expression is NO-mediated. ng-methyl-l-arginine 0-20 interleukin 1 beta Rattus norvegicus 134-142 10919268-8 2000 NG-methyl-L-arginine (LMA), a blocker of the inducible form of nitric oxide synthase (iNOS), prevented this late inhibitory effect of IL-1beta, suggesting that IL-1beta-induced decrease in PLD1a expression is NO-mediated. ng-methyl-l-arginine 0-20 interleukin 1 beta Rattus norvegicus 160-168 10919268-8 2000 NG-methyl-L-arginine (LMA), a blocker of the inducible form of nitric oxide synthase (iNOS), prevented this late inhibitory effect of IL-1beta, suggesting that IL-1beta-induced decrease in PLD1a expression is NO-mediated. dodecyl methacrylate 22-25 interleukin 1 beta Rattus norvegicus 134-142 10919268-8 2000 NG-methyl-L-arginine (LMA), a blocker of the inducible form of nitric oxide synthase (iNOS), prevented this late inhibitory effect of IL-1beta, suggesting that IL-1beta-induced decrease in PLD1a expression is NO-mediated. dodecyl methacrylate 22-25 interleukin 1 beta Rattus norvegicus 160-168 10856459-8 2000 Treatment with omeprazole or ranitidine, which completely suppressed gastric acid secretion and significantly raised plasma gastrin level, greatly reduced the formation of erosive lesions preventing the progression of these lesions to chronic gastric ulcers, and this was accompanied by the rise in gastric blood flow and plasma gastrin levels and the significant attenuation of plasma interleukin-1beta levels. Ranitidine 29-39 interleukin 1 beta Rattus norvegicus 386-403 10899932-1 2000 Ceramide produced by hydrolysis of plasma membrane sphingomyelin (SM) in different cells including brain cells in response to proinflammatory cytokines [tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta)] plays an important role in coordinating cellular responses to stress, growth suppression, and apoptosis. Ceramides 0-8 interleukin 1 beta Rattus norvegicus 194-211 10899932-1 2000 Ceramide produced by hydrolysis of plasma membrane sphingomyelin (SM) in different cells including brain cells in response to proinflammatory cytokines [tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta)] plays an important role in coordinating cellular responses to stress, growth suppression, and apoptosis. Ceramides 0-8 interleukin 1 beta Rattus norvegicus 213-221 10899932-1 2000 Ceramide produced by hydrolysis of plasma membrane sphingomyelin (SM) in different cells including brain cells in response to proinflammatory cytokines [tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta)] plays an important role in coordinating cellular responses to stress, growth suppression, and apoptosis. Sphingomyelins 51-64 interleukin 1 beta Rattus norvegicus 194-211 10899932-1 2000 Ceramide produced by hydrolysis of plasma membrane sphingomyelin (SM) in different cells including brain cells in response to proinflammatory cytokines [tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta)] plays an important role in coordinating cellular responses to stress, growth suppression, and apoptosis. Sphingomyelins 66-68 interleukin 1 beta Rattus norvegicus 194-211 10899932-1 2000 Ceramide produced by hydrolysis of plasma membrane sphingomyelin (SM) in different cells including brain cells in response to proinflammatory cytokines [tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta)] plays an important role in coordinating cellular responses to stress, growth suppression, and apoptosis. Sphingomyelins 66-68 interleukin 1 beta Rattus norvegicus 213-221 10899932-2 2000 The present study underlines the importance of IL-10 and IL-13, cytokines with potent antiinflammatory properties, in inhibiting the proinflammatory cytokine (TNF-alpha and IL-1beta)-mediated degradation of SM to ceramide in rat primary astrocytes. Ceramides 213-221 interleukin 1 beta Rattus norvegicus 173-181 10899932-3 2000 Treatment of rat primary astrocytes with TNF-alpha or IL-1beta led to rapid degradation of SM to ceramide, whereas IL-10 and IL-13 by themselves were unable to induce the degradation of SM to ceramide. Sphingomyelins 91-93 interleukin 1 beta Rattus norvegicus 54-62 10899932-3 2000 Treatment of rat primary astrocytes with TNF-alpha or IL-1beta led to rapid degradation of SM to ceramide, whereas IL-10 and IL-13 by themselves were unable to induce the degradation of SM to ceramide. Ceramides 97-105 interleukin 1 beta Rattus norvegicus 54-62 10807932-4 2000 SB203580 inhibited IL-1beta-induced up-regulation of PDGF-Ralpha mRNA and protein in a concentration-dependent manner. SB 203580 0-8 interleukin 1 beta Rattus norvegicus 19-27 10807932-6 2000 The IL-1beta-induced increase in the number of (125)I-PDGF-AA-binding sites at the cell surface was reduced >70% by pretreatment with SB203580. SB 203580 137-145 interleukin 1 beta Rattus norvegicus 4-12 10807932-7 2000 Accordingly, an enhancement of PDGF-AA-stimulated DNA synthesis following IL-1beta pretreatment was blocked >70% by SB203580. SB 203580 119-127 interleukin 1 beta Rattus norvegicus 74-82 10807932-8 2000 SB203580 did not affect IL-1beta-induced ERK activation, yet enhanced IL-1beta-induced JNK activation approximately 2-fold. SB 203580 0-8 interleukin 1 beta Rattus norvegicus 70-78 10807932-9 2000 Treatment of cells with SB203580 after inhibition of transcription by actinomycin D decreased the half-life of IL-1beta-induced PDGF-Ralpha mRNA from >4 to approximately 1.5 h. Moreover, pretreatment of cells with cycloheximide blocked induction of PDGF-Ralpha mRNA by IL-1beta, suggesting that de novo protein synthesis was required for PDGF-Ralpha mRNA stabilization. SB 203580 24-32 interleukin 1 beta Rattus norvegicus 111-119 10807932-9 2000 Treatment of cells with SB203580 after inhibition of transcription by actinomycin D decreased the half-life of IL-1beta-induced PDGF-Ralpha mRNA from >4 to approximately 1.5 h. Moreover, pretreatment of cells with cycloheximide blocked induction of PDGF-Ralpha mRNA by IL-1beta, suggesting that de novo protein synthesis was required for PDGF-Ralpha mRNA stabilization. SB 203580 24-32 interleukin 1 beta Rattus norvegicus 272-280 10807932-9 2000 Treatment of cells with SB203580 after inhibition of transcription by actinomycin D decreased the half-life of IL-1beta-induced PDGF-Ralpha mRNA from >4 to approximately 1.5 h. Moreover, pretreatment of cells with cycloheximide blocked induction of PDGF-Ralpha mRNA by IL-1beta, suggesting that de novo protein synthesis was required for PDGF-Ralpha mRNA stabilization. Dactinomycin 70-83 interleukin 1 beta Rattus norvegicus 111-119 10807932-9 2000 Treatment of cells with SB203580 after inhibition of transcription by actinomycin D decreased the half-life of IL-1beta-induced PDGF-Ralpha mRNA from >4 to approximately 1.5 h. Moreover, pretreatment of cells with cycloheximide blocked induction of PDGF-Ralpha mRNA by IL-1beta, suggesting that de novo protein synthesis was required for PDGF-Ralpha mRNA stabilization. Cycloheximide 217-230 interleukin 1 beta Rattus norvegicus 111-119 10854910-3 2000 In this study, we demonstrate that such injections of thymulin result in a significant elevation in the levels of TNF-alpha (P<0.01), NGF (P<0.01) and PGE(2) (P<0.01) in the liver of the treated rats, in addition to the increase in the levels of IL-1beta. Thymic Factor, Circulating 54-62 interleukin 1 beta Rattus norvegicus 255-263 10882405-10 2000 Moreover, CGP-43182 completely blocked IL1beta-induced gene expression of the inducible nitric oxide synthase, leading to an inhibition of cytokine-stimulated nitric oxide formation. Nitric Oxide 88-100 interleukin 1 beta Rattus norvegicus 39-46 10909968-4 2000 A 72-h exposure of RINm5F control cells to interleukin-1beta (IL-1beta) alone or a combination of IL-1beta, tumor necrosis factor-alpha, and gamma-interferon resulted in a time- and concentration-dependent decrease of cell viability in the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay. rinm5f 19-25 interleukin 1 beta Rattus norvegicus 43-60 10909968-4 2000 A 72-h exposure of RINm5F control cells to interleukin-1beta (IL-1beta) alone or a combination of IL-1beta, tumor necrosis factor-alpha, and gamma-interferon resulted in a time- and concentration-dependent decrease of cell viability in the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay. rinm5f 19-25 interleukin 1 beta Rattus norvegicus 62-70 10909968-4 2000 A 72-h exposure of RINm5F control cells to interleukin-1beta (IL-1beta) alone or a combination of IL-1beta, tumor necrosis factor-alpha, and gamma-interferon resulted in a time- and concentration-dependent decrease of cell viability in the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay. rinm5f 19-25 interleukin 1 beta Rattus norvegicus 98-106 10909968-4 2000 A 72-h exposure of RINm5F control cells to interleukin-1beta (IL-1beta) alone or a combination of IL-1beta, tumor necrosis factor-alpha, and gamma-interferon resulted in a time- and concentration-dependent decrease of cell viability in the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay. thiazolyl blue 240-301 interleukin 1 beta Rattus norvegicus 43-60 10909968-4 2000 A 72-h exposure of RINm5F control cells to interleukin-1beta (IL-1beta) alone or a combination of IL-1beta, tumor necrosis factor-alpha, and gamma-interferon resulted in a time- and concentration-dependent decrease of cell viability in the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay. thiazolyl blue 240-301 interleukin 1 beta Rattus norvegicus 62-70 10909968-4 2000 A 72-h exposure of RINm5F control cells to interleukin-1beta (IL-1beta) alone or a combination of IL-1beta, tumor necrosis factor-alpha, and gamma-interferon resulted in a time- and concentration-dependent decrease of cell viability in the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay. thiazolyl blue 240-301 interleukin 1 beta Rattus norvegicus 98-106 10909968-4 2000 A 72-h exposure of RINm5F control cells to interleukin-1beta (IL-1beta) alone or a combination of IL-1beta, tumor necrosis factor-alpha, and gamma-interferon resulted in a time- and concentration-dependent decrease of cell viability in the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay. monooxyethylene trimethylolpropane tristearate 303-306 interleukin 1 beta Rattus norvegicus 43-60 10909968-4 2000 A 72-h exposure of RINm5F control cells to interleukin-1beta (IL-1beta) alone or a combination of IL-1beta, tumor necrosis factor-alpha, and gamma-interferon resulted in a time- and concentration-dependent decrease of cell viability in the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay. monooxyethylene trimethylolpropane tristearate 303-306 interleukin 1 beta Rattus norvegicus 62-70 10909968-4 2000 A 72-h exposure of RINm5F control cells to interleukin-1beta (IL-1beta) alone or a combination of IL-1beta, tumor necrosis factor-alpha, and gamma-interferon resulted in a time- and concentration-dependent decrease of cell viability in the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay. monooxyethylene trimethylolpropane tristearate 303-306 interleukin 1 beta Rattus norvegicus 98-106 10909968-6 2000 This increased toxicity of the cytokine mixture compared with that of IL-1beta alone could be explained by a higher rate of NO generation within the early 24-48 h incubation period that would favor the toxic synergism of NO and oxygen free radicals. Oxygen 228-234 interleukin 1 beta Rattus norvegicus 70-78 10930185-4 2000 RESULTS: Ouabain (0.01-1 mmol/l) further enhanced interleukin-1beta (II-1beta)-induced nitrite production by WKY and SHR VSMC, although a more pronounced effect was observed in SHR cells (maximum response 52.1 +/- 5.2 and 71.2 +/- 6.4% of 11-1beta effect in WKY and SHR cells, respectively). Ouabain 9-16 interleukin 1 beta Rattus norvegicus 50-67 10930185-4 2000 RESULTS: Ouabain (0.01-1 mmol/l) further enhanced interleukin-1beta (II-1beta)-induced nitrite production by WKY and SHR VSMC, although a more pronounced effect was observed in SHR cells (maximum response 52.1 +/- 5.2 and 71.2 +/- 6.4% of 11-1beta effect in WKY and SHR cells, respectively). Nitrites 87-94 interleukin 1 beta Rattus norvegicus 50-67 10930185-4 2000 RESULTS: Ouabain (0.01-1 mmol/l) further enhanced interleukin-1beta (II-1beta)-induced nitrite production by WKY and SHR VSMC, although a more pronounced effect was observed in SHR cells (maximum response 52.1 +/- 5.2 and 71.2 +/- 6.4% of 11-1beta effect in WKY and SHR cells, respectively). vsmc 121-125 interleukin 1 beta Rattus norvegicus 50-67 10864917-3 2000 IL-1beta, and to a lesser extent TNF-alpha, decreased collagen synthesis, which was measured as collagenase-sensitive [(3)H]proline incorporation, but had no effect on cell number or total protein synthesis. Proline 124-131 interleukin 1 beta Rattus norvegicus 0-8 10861753-6 2000 After 4 weeks of treatment with E(2) + DHT, a significant increase in transcript levels of IL-4, IL-5, IL-6, MIP-2, eotaxin, and iNOS was detected, while IL-1beta and TNF-alpha transcript levels only increased slightly. Estradiol 32-36 interleukin 1 beta Rattus norvegicus 154-162 10861753-6 2000 After 4 weeks of treatment with E(2) + DHT, a significant increase in transcript levels of IL-4, IL-5, IL-6, MIP-2, eotaxin, and iNOS was detected, while IL-1beta and TNF-alpha transcript levels only increased slightly. dihydrotestosterone propionate 39-42 interleukin 1 beta Rattus norvegicus 154-162 10856459-8 2000 Treatment with omeprazole or ranitidine, which completely suppressed gastric acid secretion and significantly raised plasma gastrin level, greatly reduced the formation of erosive lesions preventing the progression of these lesions to chronic gastric ulcers, and this was accompanied by the rise in gastric blood flow and plasma gastrin levels and the significant attenuation of plasma interleukin-1beta levels. Omeprazole 15-25 interleukin 1 beta Rattus norvegicus 386-403 10929089-1 2000 The limited entry of interleukin-1beta (IL-1beta) into the central nervous system has led to the hypothesis that IL-1beta acts, through IL-1beta receptors located notably on endothelial cells, on the release of prostaglandins which in turn stimulate the hypothalamic-pituitary-adrenal (HPA) axis. Prostaglandins 211-225 interleukin 1 beta Rattus norvegicus 21-38 10929089-1 2000 The limited entry of interleukin-1beta (IL-1beta) into the central nervous system has led to the hypothesis that IL-1beta acts, through IL-1beta receptors located notably on endothelial cells, on the release of prostaglandins which in turn stimulate the hypothalamic-pituitary-adrenal (HPA) axis. Prostaglandins 211-225 interleukin 1 beta Rattus norvegicus 40-48 10929089-1 2000 The limited entry of interleukin-1beta (IL-1beta) into the central nervous system has led to the hypothesis that IL-1beta acts, through IL-1beta receptors located notably on endothelial cells, on the release of prostaglandins which in turn stimulate the hypothalamic-pituitary-adrenal (HPA) axis. Prostaglandins 211-225 interleukin 1 beta Rattus norvegicus 113-121 10929089-1 2000 The limited entry of interleukin-1beta (IL-1beta) into the central nervous system has led to the hypothesis that IL-1beta acts, through IL-1beta receptors located notably on endothelial cells, on the release of prostaglandins which in turn stimulate the hypothalamic-pituitary-adrenal (HPA) axis. Prostaglandins 211-225 interleukin 1 beta Rattus norvegicus 113-121 10929089-9 2000 These results demonstrate the crucial role of eicosanoid pathways in mediating the stimulation of the HPA axis induced by IL-1beta. Eicosanoids 46-56 interleukin 1 beta Rattus norvegicus 122-130 10929089-10 2000 Moreover, we found a clear dissociation of the effect of the blockage of COXs upon ACTH and corticosterone secretion, suggesting that IL-1beta may act at the brain as well as at the adrenal cortex to stimulate the secretion of corticosterone. Corticosterone 92-106 interleukin 1 beta Rattus norvegicus 134-142 10929089-10 2000 Moreover, we found a clear dissociation of the effect of the blockage of COXs upon ACTH and corticosterone secretion, suggesting that IL-1beta may act at the brain as well as at the adrenal cortex to stimulate the secretion of corticosterone. Corticosterone 227-241 interleukin 1 beta Rattus norvegicus 134-142 10903982-22 2000 In addition, NO-naproxen reduced both IL-1beta and TNFalpha plasma levels whilst naproxen reduced IL-1beta levels only. naproxen-n-butyl nitrate 13-24 interleukin 1 beta Rattus norvegicus 38-46 10903982-22 2000 In addition, NO-naproxen reduced both IL-1beta and TNFalpha plasma levels whilst naproxen reduced IL-1beta levels only. Naproxen 16-24 interleukin 1 beta Rattus norvegicus 38-46 10903985-9 2000 Carrageenin and LPS stimulated and production of immunoreactive TNFalpha, IL-1beta and IL-1ra in the skin of injected paws. Carrageenan 0-11 interleukin 1 beta Rattus norvegicus 74-82 10903985-17 2000 This effect is independent of (IL-1ra-induced) IL-4 and IL-10 and appears to be the result of antagonism by IL-1ra of IL-1beta-stimulated eicosanoid production. Eicosanoids 138-148 interleukin 1 beta Rattus norvegicus 118-126 10875263-6 2000 Dimethyl-PGE2 (1.4 x 10(-5) M) or interleukin-1beta (2.5 x 10(-10) M) induced a 3-fold increase in G-IR in the lumen, whereas the degranulator compound bromolasalocid did not stimulate guanylin secretion. bromolasalocid 152-166 interleukin 1 beta Rattus norvegicus 34-51 10875263-6 2000 Dimethyl-PGE2 (1.4 x 10(-5) M) or interleukin-1beta (2.5 x 10(-10) M) induced a 3-fold increase in G-IR in the lumen, whereas the degranulator compound bromolasalocid did not stimulate guanylin secretion. guanylin 185-193 interleukin 1 beta Rattus norvegicus 34-51 10844008-8 2000 Likewise, brain levels of the proinflammatory cytokines IL-1beta and TNF-alpha were reduced at 24 hr (39.5 +/- 23.7 and 51.9 +/- 10.3% of control, respectively) but not at 6 d. Other cytokines, IL-10, MCP-1, MIP-2, and the gaseous mediator nitric oxide, were not modified by the treatment. Nitric Oxide 240-252 interleukin 1 beta Rattus norvegicus 56-64 10843734-3 2000 In cultures of adult rat thymocytes, activin-A inhibited sub-optimal phytohemagglutinin-induced and interleukin 1beta-stimulated proliferation, as measured by [(3)H]-thymidine incorporation in vitro. Thymidine 166-175 interleukin 1 beta Rattus norvegicus 100-117 10859218-2 2000 The present study focuses on the induction of inducible nitric oxide (NO) synthase in cocultures of freshly isolated rat IEL and the rat epithelial cell line IEC-18 after the addition of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha, or lipopolysaccharide. Nitric Oxide 56-68 interleukin 1 beta Rattus norvegicus 187-204 10859218-2 2000 The present study focuses on the induction of inducible nitric oxide (NO) synthase in cocultures of freshly isolated rat IEL and the rat epithelial cell line IEC-18 after the addition of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha, or lipopolysaccharide. Nitric Oxide 56-68 interleukin 1 beta Rattus norvegicus 206-214 10830310-9 2000 In vivo, interleukin-1beta (10 ng, intracerebroventricularly) produced a significant increase in the serum PRL concentration (P < 0.01), which was prevented by pretreatment of the rats with corticosterone (100 microg/100 g BW, sc). Corticosterone 193-207 interleukin 1 beta Rattus norvegicus 9-26 10903806-4 2000 IL-1 beta, but not interferon-gamma (IFN-gamma), caused phosphorylation of the substrates Elk-1, ATF-2 and hsp25, and the phosphorylation of both Elk-1 and hsp25 were decreased by the p38 blocker SB203580 (p38i) and the MAPK/ERK blocker PD 098059 (MEKi). SB 203580 196-204 interleukin 1 beta Rattus norvegicus 0-9 10903806-5 2000 When added together, p38i and MEKi decreased IL-1 beta-induced nitrite production over 24 hours by 60%, but did not affect IL-1 beta-induced manganese superoxide dismutase (MnSOD) mRNA expression. Nitrites 63-70 interleukin 1 beta Rattus norvegicus 45-54 10938453-11 2000 In saline-injected controls both mRNA and protein for IL-1beta, IL-6, and TNF-alpha were detected at 1 h R; levels remained high until 3 h, then fell (except IL-6, which was elevated at 6 h). Sodium Chloride 3-9 interleukin 1 beta Rattus norvegicus 54-62 11967814-14 2000 The studies also suggest that the inhibitory action of losartan on the SNS may be mediated by activation of IL-1beta, which, in turn, stimulates nNOS, an important modulator of central SNS activity. Losartan 55-63 interleukin 1 beta Rattus norvegicus 108-116 10843870-3 2000 Small GTP-binding proteins of the Ras superfamily play a major role in IL-1beta-dependent signaling pathways. Guanosine Triphosphate 6-9 interleukin 1 beta Rattus norvegicus 71-79 10843870-5 2000 Treatment of VSMCs with mevastatin, which inhibits isoprenylation of Rho and other small GTP-binding proteins, produced significantly higher amounts of IL-1beta-evoked NO and iNOS protein compared with control. mevastatin 24-34 interleukin 1 beta Rattus norvegicus 152-160 10843870-5 2000 Treatment of VSMCs with mevastatin, which inhibits isoprenylation of Rho and other small GTP-binding proteins, produced significantly higher amounts of IL-1beta-evoked NO and iNOS protein compared with control. Guanosine Triphosphate 89-92 interleukin 1 beta Rattus norvegicus 152-160 10923243-5 2000 Crocidolite and chrysotile fibers induced MCP-1 mRNA expression in RPMC which was maximal after 12 hours in the absence of cytokines, but which peaked after 2 hours when RPMC were challenged with asbestos + TNF-alpha or IL-1 beta. Asbestos, Crocidolite 0-11 interleukin 1 beta Rattus norvegicus 220-229 10856269-4 2000 Incubation of cultures with interleukin-1beta (10 ng/mL) for 24 hours caused a significant increase in the production of nitrite, a stable metabolite of NO, in cultured rat vascular smooth muscle cells. Nitrites 121-128 interleukin 1 beta Rattus norvegicus 28-45 10856269-5 2000 The PPARgamma agonists troglitazone and 15-deoxy-triangle up(12,14)-prostaglandin J(2) (15d-PG J(2)) dose-dependently inhibited nitrite production by interleukin-1beta-stimulated vascular smooth muscle cells. Troglitazone 23-35 interleukin 1 beta Rattus norvegicus 150-167 10856269-5 2000 The PPARgamma agonists troglitazone and 15-deoxy-triangle up(12,14)-prostaglandin J(2) (15d-PG J(2)) dose-dependently inhibited nitrite production by interleukin-1beta-stimulated vascular smooth muscle cells. 15-deoxy-triangle up(12,14)-prostaglandin j 40-83 interleukin 1 beta Rattus norvegicus 150-167 10856269-5 2000 The PPARgamma agonists troglitazone and 15-deoxy-triangle up(12,14)-prostaglandin J(2) (15d-PG J(2)) dose-dependently inhibited nitrite production by interleukin-1beta-stimulated vascular smooth muscle cells. Nitrites 128-135 interleukin 1 beta Rattus norvegicus 150-167 10856269-6 2000 Decreased interleukin-1beta-induced nitrite production by the PPARgamma agonists was accompanied by decreased inducible NO synthase mRNA and protein accumulation. Nitrites 36-43 interleukin 1 beta Rattus norvegicus 10-27 10740232-0 2000 Increased expression of mRNA encoding interleukin-1beta and caspase-1, and the secreted isoform of interleukin-1 receptor antagonist in the rat brain following systemic kainic acid administration. Kainic Acid 169-180 interleukin 1 beta Rattus norvegicus 38-55 10790354-7 2000 Metoprolol administration starting 48 hours after infarction (1) attenuated (P<0.02) LV dilatation and systolic dysfunction, (2) preserved isoproterenol responsiveness (P<0.025) via NO-independent mechanisms, and (3) reduced myocardial gene expression and protein production of TNF-alpha and IL-1beta (P<0. Metoprolol 0-10 interleukin 1 beta Rattus norvegicus 298-306 10818069-3 2000 Sodium salicylate, aspirin, and indomethacin dose-dependently enhanced nitrite production by interleukin (IL)-1beta-stimulated VSMCs at therapeutic plasma concentration ranges. Sodium Salicylate 0-17 interleukin 1 beta Rattus norvegicus 93-115 10818069-3 2000 Sodium salicylate, aspirin, and indomethacin dose-dependently enhanced nitrite production by interleukin (IL)-1beta-stimulated VSMCs at therapeutic plasma concentration ranges. Aspirin 19-26 interleukin 1 beta Rattus norvegicus 93-115 10818069-3 2000 Sodium salicylate, aspirin, and indomethacin dose-dependently enhanced nitrite production by interleukin (IL)-1beta-stimulated VSMCs at therapeutic plasma concentration ranges. Indomethacin 32-44 interleukin 1 beta Rattus norvegicus 93-115 10818069-3 2000 Sodium salicylate, aspirin, and indomethacin dose-dependently enhanced nitrite production by interleukin (IL)-1beta-stimulated VSMCs at therapeutic plasma concentration ranges. Nitrites 71-78 interleukin 1 beta Rattus norvegicus 93-115 10818069-7 2000 The 12-LO product 12-HETE dose-dependently enhanced nitrite production by IL-1beta-stimulated VSMCs, whereas the 15-LO product 15-HETE did not. Nitrites 52-59 interleukin 1 beta Rattus norvegicus 74-82 10818069-8 2000 Our study demonstrates that aspirin and the aspirin-like drugs, sodium salicylate and indomethacin, increase NO synthesis in IL-1beta-stimulated VSMCs by upregulation of iNOS transcription via a 12-LO pathway. Aspirin 28-35 interleukin 1 beta Rattus norvegicus 125-133 10818069-8 2000 Our study demonstrates that aspirin and the aspirin-like drugs, sodium salicylate and indomethacin, increase NO synthesis in IL-1beta-stimulated VSMCs by upregulation of iNOS transcription via a 12-LO pathway. Aspirin 44-51 interleukin 1 beta Rattus norvegicus 125-133 10818069-8 2000 Our study demonstrates that aspirin and the aspirin-like drugs, sodium salicylate and indomethacin, increase NO synthesis in IL-1beta-stimulated VSMCs by upregulation of iNOS transcription via a 12-LO pathway. Sodium Salicylate 64-81 interleukin 1 beta Rattus norvegicus 125-133 10818069-8 2000 Our study demonstrates that aspirin and the aspirin-like drugs, sodium salicylate and indomethacin, increase NO synthesis in IL-1beta-stimulated VSMCs by upregulation of iNOS transcription via a 12-LO pathway. Indomethacin 86-98 interleukin 1 beta Rattus norvegicus 125-133 10800959-0 2000 A functional analysis of EP4 receptor-expressing neurons in mediating the action of prostaglandin E2 within specific nuclei of the brain in response to circulating interleukin-1beta. Dinoprostone 84-100 interleukin 1 beta Rattus norvegicus 164-181 10800959-3 2000 In a first set of experiments, animals were treated with the inhibitor of PG synthesis ketorolac to determine the endogenous contribution of PG in mediating the neuronal activation and EP4 expression in response to circulating interleukin-1beta(IL-1beta). Prostaglandins 141-143 interleukin 1 beta Rattus norvegicus 227-244 10800959-7 2000 Of interest are the data that central PGE2 injection activated EP4 gene transcription in neurons that no longer responded to the intravenous IL-1beta bolus when the animals were pretreated with ketorolac. Dinoprostone 38-42 interleukin 1 beta Rattus norvegicus 141-149 10800959-9 2000 Both intracerebroventricular PGE2 and intravenous IL-1beta injection provoked a sharp and rapid increase in plasma corticosterone levels, an effect that was completely prevented in inhibiting PG production in IL-1beta-challenged rats. Dinoprostone 29-33 interleukin 1 beta Rattus norvegicus 209-217 10800959-9 2000 Both intracerebroventricular PGE2 and intravenous IL-1beta injection provoked a sharp and rapid increase in plasma corticosterone levels, an effect that was completely prevented in inhibiting PG production in IL-1beta-challenged rats. Corticosterone 115-129 interleukin 1 beta Rattus norvegicus 50-58 10800959-9 2000 Both intracerebroventricular PGE2 and intravenous IL-1beta injection provoked a sharp and rapid increase in plasma corticosterone levels, an effect that was completely prevented in inhibiting PG production in IL-1beta-challenged rats. Corticosterone 115-129 interleukin 1 beta Rattus norvegicus 209-217 10800959-9 2000 Both intracerebroventricular PGE2 and intravenous IL-1beta injection provoked a sharp and rapid increase in plasma corticosterone levels, an effect that was completely prevented in inhibiting PG production in IL-1beta-challenged rats. Prostaglandins 29-31 interleukin 1 beta Rattus norvegicus 209-217 10779559-4 2000 We show that IL-1beta injected into the rat striatum with the excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (S-AMPA) caused increased expression of IL-1beta (mRNA and protein) mainly in the cortex where maximum injury occurs. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate 74-126 interleukin 1 beta Rattus norvegicus 13-21 10779559-4 2000 We show that IL-1beta injected into the rat striatum with the excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (S-AMPA) caused increased expression of IL-1beta (mRNA and protein) mainly in the cortex where maximum injury occurs. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate 74-126 interleukin 1 beta Rattus norvegicus 167-175 10857764-0 2000 The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1 beta in rat cortical synaptosomes. Ceramides 12-20 interleukin 1 beta Rattus norvegicus 71-89 10857764-2 2000 We now report that the effects of IL-1beta on [Ca2+]i are mimicked by the sphingolipid metabolite ceramide. Sphingolipids 74-86 interleukin 1 beta Rattus norvegicus 34-42 10857764-2 2000 We now report that the effects of IL-1beta on [Ca2+]i are mimicked by the sphingolipid metabolite ceramide. Ceramides 98-106 interleukin 1 beta Rattus norvegicus 34-42 10857764-3 2000 In cortical synaptosomes ceramide elevates [Ca2+]i in a p42 MAP kinase-dependent manner, and we conclude that the effects of IL-1beta on Ca2+ homeostasis involve ceramide as an upstream component of the p42 MAP kinase pathway. Ceramides 162-170 interleukin 1 beta Rattus norvegicus 125-133 10772914-5 2000 The synthetic retinoid agonists CD336 (which specifically binds RARalpha) and CD367 (which binds all RARs) but not agonists specific for RARbeta, RARgamma, or RXRs reduced IL-1beta-induced NOS2 expression and NO production. Retinoids 14-22 interleukin 1 beta Rattus norvegicus 172-180 10772914-5 2000 The synthetic retinoid agonists CD336 (which specifically binds RARalpha) and CD367 (which binds all RARs) but not agonists specific for RARbeta, RARgamma, or RXRs reduced IL-1beta-induced NOS2 expression and NO production. Am 580 32-37 interleukin 1 beta Rattus norvegicus 172-180 10740232-2 2000 In the present study, we have analyzed the temporal profile of the expression of the cytokines interleukin-1beta (IL-1beta) and IL-1 receptor antagonist (IL-1ra), and the related IL-1beta-converting enzyme (ICE/caspase-1), in different regions of the rat brain in response to peripheral kainic acid administration (10 mg/kg, i.p.). Kainic Acid 287-298 interleukin 1 beta Rattus norvegicus 95-112 10740232-9 2000 In conclusion, in response to systemic kainic acid injection IL-1beta mRNA is rapidly induced and followed by induction of IL-1ra mRNA and caspase-1 mRNA, supporting a role of the IL-1 system in the inflammatory response during excitotoxic damage. Kainic Acid 39-50 interleukin 1 beta Rattus norvegicus 61-69 10818485-3 2000 A strengthening of the cyclic adenosine-5",3"-monophosphate (cAMP) signaling exerted a differential inhibition of the stimulatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) released from cultured rat microglia, but maintained the negative feedback signal IL-6; cAMP inhibited also the release of free oxygen radicals (OR) but not of NO. Adenosine 30-39 interleukin 1 beta Rattus norvegicus 184-202 10818485-3 2000 A strengthening of the cyclic adenosine-5",3"-monophosphate (cAMP) signaling exerted a differential inhibition of the stimulatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) released from cultured rat microglia, but maintained the negative feedback signal IL-6; cAMP inhibited also the release of free oxygen radicals (OR) but not of NO. Cyclic AMP 61-65 interleukin 1 beta Rattus norvegicus 184-202 10775561-0 2000 N-Acetyl-L-cysteine potentiates interleukin-1beta induction of nitric oxide synthase : role of p44/42 mitogen-activated protein kinases. Acetylcysteine 0-19 interleukin 1 beta Rattus norvegicus 32-49 10734001-5 2000 In vitro activation of CNS endothelium with the pro-inflammatory cytokines, tumour necrosis factor-alpha and interleukin-1beta, resulted in selective upregulation of MMP-9 activity, whereas no significant changes were seen in MMP-2 or TIMP-2 levels at 24 h. The addition of dexamethasone partially inhibited the cytokine-induced upregulation of MMP-9. Dexamethasone 274-287 interleukin 1 beta Rattus norvegicus 109-126 10871193-4 2000 Based on the C,N diphenyl-N"-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium+ ++ bromide (MTT) viability assay, the selected cells, termed INS-1res, were 100% viable after 5 days of treatment with 10 ng/ml of IL-1beta. c,n diphenyl-n"-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium+ ++ bromide 13-91 interleukin 1 beta Rattus norvegicus 212-220 10871193-12 2000 However, normal IL-1beta-mediated translocation of NF-kappaB and induction of inducible nitric oxide synthase expression and nitric oxide production was severely impaired in the INS-1res cell lines, suggesting a mechanism for the IL-1beta resistance. Nitric Oxide 88-100 interleukin 1 beta Rattus norvegicus 16-24 10775561-3 2000 The effect of N-acetyl-L-cysteine on potentiating interleukin-1beta-induced nitrite production and iNOS expression was mimicked either by the enantiomers, L-cysteine and D-cysteine, or by a non-thiol-containing antioxidant, L-ascorbic acid. Acetylcysteine 14-33 interleukin 1 beta Rattus norvegicus 50-67 10775561-3 2000 The effect of N-acetyl-L-cysteine on potentiating interleukin-1beta-induced nitrite production and iNOS expression was mimicked either by the enantiomers, L-cysteine and D-cysteine, or by a non-thiol-containing antioxidant, L-ascorbic acid. Nitrites 76-83 interleukin 1 beta Rattus norvegicus 50-67 10775561-3 2000 The effect of N-acetyl-L-cysteine on potentiating interleukin-1beta-induced nitrite production and iNOS expression was mimicked either by the enantiomers, L-cysteine and D-cysteine, or by a non-thiol-containing antioxidant, L-ascorbic acid. Cysteine 23-33 interleukin 1 beta Rattus norvegicus 50-67 10775561-3 2000 The effect of N-acetyl-L-cysteine on potentiating interleukin-1beta-induced nitrite production and iNOS expression was mimicked either by the enantiomers, L-cysteine and D-cysteine, or by a non-thiol-containing antioxidant, L-ascorbic acid. D-cysteine 170-180 interleukin 1 beta Rattus norvegicus 50-67 10775561-3 2000 The effect of N-acetyl-L-cysteine on potentiating interleukin-1beta-induced nitrite production and iNOS expression was mimicked either by the enantiomers, L-cysteine and D-cysteine, or by a non-thiol-containing antioxidant, L-ascorbic acid. Sulfhydryl Compounds 194-199 interleukin 1 beta Rattus norvegicus 50-67 10775561-3 2000 The effect of N-acetyl-L-cysteine on potentiating interleukin-1beta-induced nitrite production and iNOS expression was mimicked either by the enantiomers, L-cysteine and D-cysteine, or by a non-thiol-containing antioxidant, L-ascorbic acid. Ascorbic Acid 224-239 interleukin 1 beta Rattus norvegicus 50-67 10775561-4 2000 Interleukin-1beta activated p44/42 MAPK, and this activation was enhanced in the presence of N-acetyl-L-cysteine. Acetylcysteine 93-112 interleukin 1 beta Rattus norvegicus 0-17 10775561-5 2000 Inhibition of p44/42 MAPK phosphorylation by the selective inhibitor PD98059 clearly inhibited iNOS expression induced by interleukin-1beta either in the absence or in the presence of N-acetyl-L-cysteine. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 69-76 interleukin 1 beta Rattus norvegicus 122-139 10775561-6 2000 These observations, combined with previous results, indicate that p44/42 MAPK activation is required for interleukin-1beta induction of iNOS and that N-acetyl-L-cysteine may act as a reducing agent and facilitate interleukin-1beta-induced iNOS expression through a reduction/oxidation-related mechanism involving potentiation of cytokine activation of the p44/42 MAPK signaling pathway. Acetylcysteine 150-169 interleukin 1 beta Rattus norvegicus 213-230 10758978-1 2000 OBJECTIVES: The present study examined whether nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) can directly inhibit aerobic energy metabolism and impair cell function in interleukin (IL)-1beta,-stimulated cardiac myocytes. Nitric Oxide 47-59 interleukin 1 beta Rattus norvegicus 191-213 10858015-8 2000 RESULTS: MTX-EPC and MTX-PEG respectively (15 microg of MTX and 0.15 mg of lipid) were powerful inhibitors of both IL-1beta (77 +/- 2.3%; 79 +/- 4.0%) and PGE2 (75.5 +/- 4.9%; 68.5 +/- 2.3%) release (mean +/- SEM % inhibition) from lipopolysaccaride stimulated rPM phi. mtx-epc 9-16 interleukin 1 beta Rattus norvegicus 115-123 10858015-8 2000 RESULTS: MTX-EPC and MTX-PEG respectively (15 microg of MTX and 0.15 mg of lipid) were powerful inhibitors of both IL-1beta (77 +/- 2.3%; 79 +/- 4.0%) and PGE2 (75.5 +/- 4.9%; 68.5 +/- 2.3%) release (mean +/- SEM % inhibition) from lipopolysaccaride stimulated rPM phi. mtx-peg 21-28 interleukin 1 beta Rattus norvegicus 115-123 10858015-8 2000 RESULTS: MTX-EPC and MTX-PEG respectively (15 microg of MTX and 0.15 mg of lipid) were powerful inhibitors of both IL-1beta (77 +/- 2.3%; 79 +/- 4.0%) and PGE2 (75.5 +/- 4.9%; 68.5 +/- 2.3%) release (mean +/- SEM % inhibition) from lipopolysaccaride stimulated rPM phi. Methotrexate 9-12 interleukin 1 beta Rattus norvegicus 115-123 10758978-5 2000 RESULTS: Treatment with IL-1beta (10 ng/ml) increased myocyte production of NOx in a time-dependent manner. nicotine 1-N-oxide 76-79 interleukin 1 beta Rattus norvegicus 24-32 10758978-10 2000 Both IL-1beta and SNP significantly elevated maximum diastolic potential, reduced peak calcium current (I(Ca)), and lowered contractility in the myocytes. Calcium 87-94 interleukin 1 beta Rattus norvegicus 5-13 10758978-12 2000 CONCLUSIONS: These data suggest that IL-1beta-induced NO production in cardiac myocytes lowers energy production and myocardial contractility through a direct attack on the mitochondria, rather than through cGMP-mediated pathways. Cyclic GMP 207-211 interleukin 1 beta Rattus norvegicus 37-45 10823728-3 2000 Prior treatment of rats with gadolinium chloride, which eliminates macrophages, prevented the stress-induced IL-1beta expression. gadolinium chloride 29-48 interleukin 1 beta Rattus norvegicus 109-117 10823728-6 2000 These results suggest that oscillation stress induces IL-1beta mRNA expression in the liver and spleen, probably in Kupffer cells and splenic macrophages, and that stress-induced IL-1beta expression is elicited by catecholamines released from sympathetic nerve terminals and the adrenal gland. Catecholamines 214-228 interleukin 1 beta Rattus norvegicus 179-187 10717414-5 2000 The P(2U) agonist, UTP, maintained the BrdU incorporation, whereas the P(2Z) agonist, BzATP, suppressed it, but significantly enhanced IL-1beta and TNF-alpha release, suggesting that the P(2U) response may underlie the mitotic activity, and that of P(2Z), the IL-1beta and TNF-alpha release of hypoxia-activated microglia. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 86-91 interleukin 1 beta Rattus norvegicus 135-143 10876802-5 2000 TNF-alpha and IL-1 beta were released in both LPS- and hypoxia-activated states, enhanced by the P2Z agonist BzATP and suppressed by the antagonist oATP, indicating P2Z involvement in their release. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 109-114 interleukin 1 beta Rattus norvegicus 14-23 10876802-5 2000 TNF-alpha and IL-1 beta were released in both LPS- and hypoxia-activated states, enhanced by the P2Z agonist BzATP and suppressed by the antagonist oATP, indicating P2Z involvement in their release. periodate-oxidized adenosine 5'-triphosphate 148-152 interleukin 1 beta Rattus norvegicus 14-23 10677589-2 2000 ACR at concentrations as low as 0.1 microM significantly inhibited NO production induced by interleukin-1beta in RASMCs. rasmcs 113-119 interleukin 1 beta Rattus norvegicus 92-109 10868954-6 2000 This IL-1beta-induced alteration in beta-cell phenotype resulted in a reduced cellular sensitivity to the beta-cell-specific toxins ALX and STZ; the production of nontoxic conditions of nitric oxide (NO) also rendered the cells less susceptible to radical-induced damage. Streptozocin 140-143 interleukin 1 beta Rattus norvegicus 5-13 10712388-9 2000 L-NAME and DAHP totally inhibited NO generation and decreased the IL-1beta-upregulated VEGF synthesis by 30% to 40%. NG-Nitroarginine Methyl Ester 0-6 interleukin 1 beta Rattus norvegicus 66-74 10712388-9 2000 L-NAME and DAHP totally inhibited NO generation and decreased the IL-1beta-upregulated VEGF synthesis by 30% to 40%. 5-dehydro-3-deoxy-D-arabino-heptulosonic acid-7-phosphate 11-15 interleukin 1 beta Rattus norvegicus 66-74 10868954-4 2000 After a 24-h culture with IL-1beta (30 U/ml), beta-cells exhibited a lower expression of the beta-cell-specific protein transcription factor pancreatic and duodenal homeobox gene (PDX)-1, glucose transporter GLUT2, and proinsulin convertase PC2, with a marked reduction (60-70%) in glucose-induced insulin production and selective sensitivity to the toxins alloxan (ALX) and streptozotocin (STZ). Glucose 188-195 interleukin 1 beta Rattus norvegicus 26-34 10725264-7 2000 Both, nifedipine and Bay w 9798, in concentrations ranging from 0.01 to 1 microM, augmented the interleukin-1beta/tumour necrosis factor-alpha (IL-1beta/TNF-alpha)-induced expression of the inducible isoform of nitric oxide synthase (iNOS) in rat aortic cultured smooth muscle cells (raSMC) 2 - 3 fold, as judged by RT - PCR and Western blot analyses. Nifedipine 6-16 interleukin 1 beta Rattus norvegicus 144-152 10725264-7 2000 Both, nifedipine and Bay w 9798, in concentrations ranging from 0.01 to 1 microM, augmented the interleukin-1beta/tumour necrosis factor-alpha (IL-1beta/TNF-alpha)-induced expression of the inducible isoform of nitric oxide synthase (iNOS) in rat aortic cultured smooth muscle cells (raSMC) 2 - 3 fold, as judged by RT - PCR and Western blot analyses. Bay w 9798 21-31 interleukin 1 beta Rattus norvegicus 144-152 10868954-6 2000 This IL-1beta-induced alteration in beta-cell phenotype resulted in a reduced cellular sensitivity to the beta-cell-specific toxins ALX and STZ; the production of nontoxic conditions of nitric oxide (NO) also rendered the cells less susceptible to radical-induced damage. Nitric Oxide 186-198 interleukin 1 beta Rattus norvegicus 5-13 10868954-4 2000 After a 24-h culture with IL-1beta (30 U/ml), beta-cells exhibited a lower expression of the beta-cell-specific protein transcription factor pancreatic and duodenal homeobox gene (PDX)-1, glucose transporter GLUT2, and proinsulin convertase PC2, with a marked reduction (60-70%) in glucose-induced insulin production and selective sensitivity to the toxins alloxan (ALX) and streptozotocin (STZ). Alloxan 366-369 interleukin 1 beta Rattus norvegicus 26-34 10868954-4 2000 After a 24-h culture with IL-1beta (30 U/ml), beta-cells exhibited a lower expression of the beta-cell-specific protein transcription factor pancreatic and duodenal homeobox gene (PDX)-1, glucose transporter GLUT2, and proinsulin convertase PC2, with a marked reduction (60-70%) in glucose-induced insulin production and selective sensitivity to the toxins alloxan (ALX) and streptozotocin (STZ). Streptozocin 375-389 interleukin 1 beta Rattus norvegicus 26-34 10702213-0 2000 Superoxide enhances interleukin 1beta-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene. Superoxides 0-10 interleukin 1 beta Rattus norvegicus 20-37 10868954-4 2000 After a 24-h culture with IL-1beta (30 U/ml), beta-cells exhibited a lower expression of the beta-cell-specific protein transcription factor pancreatic and duodenal homeobox gene (PDX)-1, glucose transporter GLUT2, and proinsulin convertase PC2, with a marked reduction (60-70%) in glucose-induced insulin production and selective sensitivity to the toxins alloxan (ALX) and streptozotocin (STZ). Streptozocin 391-394 interleukin 1 beta Rattus norvegicus 26-34 10868954-6 2000 This IL-1beta-induced alteration in beta-cell phenotype resulted in a reduced cellular sensitivity to the beta-cell-specific toxins ALX and STZ; the production of nontoxic conditions of nitric oxide (NO) also rendered the cells less susceptible to radical-induced damage. Alloxan 132-135 interleukin 1 beta Rattus norvegicus 5-13 10702213-2 2000 In interleukin 1beta (IL-1beta)-treated rat hepatocytes, we have previously demonstrated that inducible nitric oxide synthase (iNOS) protein expression, steady-state iNOS messenger RNA (mRNA) levels, and NO synthesis are increased by oxidative stress induced by superoxide. Superoxides 262-272 interleukin 1 beta Rattus norvegicus 22-30 10702213-12 2000 CONCLUSIONS: An ARE in the rat hepatocyte iNOS promoter confers redox sensitivity and augments IL-1beta-mediated iNOS gene and protein expression in the setting of superoxide treatment. Superoxides 164-174 interleukin 1 beta Rattus norvegicus 95-103 10718379-0 2000 Role of endogenous nitric oxide in TNF-alpha and IL-1beta generation in hepatic ischemia-repefusion. Nitric Oxide 19-31 interleukin 1 beta Rattus norvegicus 49-57 10702202-2 2000 Previous studies have shown that the proinflammatory cytokine interleukin (IL)-1beta present during chronic gastritis inhibits histamine synthesis in ECL cells and leads to sustained functional impairment. Histamine 127-136 interleukin 1 beta Rattus norvegicus 62-84 10807497-0 2000 Augmented prostaglandin E2 generation resulting from increased activities of cytosolic and secretory phospholipase A2 and induction of cyclooxygenase-2 in interleukin-1 beta-stimulated rat calvarial cells during the mineralizing phase. Dinoprostone 10-26 interleukin 1 beta Rattus norvegicus 155-173 10807497-5 2000 RESULTS: The PGE2 concentration in the medium of the day 21 cells was increased 72 h after IL-1beta treatment, and reached a peak level approximately 1,400 times that of the day 0 cells 6 h after IL-1beta treatment. Dinoprostone 13-17 interleukin 1 beta Rattus norvegicus 91-99 10807497-5 2000 RESULTS: The PGE2 concentration in the medium of the day 21 cells was increased 72 h after IL-1beta treatment, and reached a peak level approximately 1,400 times that of the day 0 cells 6 h after IL-1beta treatment. Dinoprostone 13-17 interleukin 1 beta Rattus norvegicus 196-204 10807497-8 2000 Taken together, these results indicate that COX-2 and cPLA2 play pivotal roles and sPLA2 is involved in IL-1beta-stimulated PGE2 production by these cells. Dinoprostone 124-128 interleukin 1 beta Rattus norvegicus 104-112 10807497-10 2000 CONCLUSION: Augmented PGE2 production by mineralizing osteoblasts after IL-1beta treatment, and the involvement of IL-1beta-induced cPLA2, sPLA2, COX-2 and PGE synthase activities in this phenomenon were demonstrated. Dinoprostone 22-26 interleukin 1 beta Rattus norvegicus 72-80 10718379-10 2000 The observed enhancement of I/R injury by L-NAME is consistent with the hypothesis that endogenous NO down-regulates TNF-alpha and IL1beta generation, thereby decreasing HI/R injury. NG-Nitroarginine Methyl Ester 42-48 interleukin 1 beta Rattus norvegicus 131-138 10660607-1 2000 Inflammatory cytokine interleukin 1beta induces inducible nitric-oxide synthase (iNOS) mRNA and its protein, which are followed by increasing the production of nitric oxide, in primary cultures of rat hepatocytes. Nitric Oxide 160-172 interleukin 1 beta Rattus norvegicus 22-39 10657625-7 2000 OX8 (CD8 alpha)-induced TNF and IL-1 beta production by macrophages was blocked by inhibitors of protein tyrosine kinase(s), PP1, and genistein, but not by phosphatidylinositol-3 kinase inhibitor, wortmannin. Genistein 134-143 interleukin 1 beta Rattus norvegicus 32-41 10657625-4 2000 Similarly, OX8 Ab (CD8 alpha) stimulated NR8383 cells to secrete TNF, IL-1 beta, and NO. ox8 ab 11-17 interleukin 1 beta Rattus norvegicus 70-79 11268388-4 2000 In the rat C6 glioma cell line, IL-1 beta synergistically stimulates IL-6 release in the presence of increased intracellular cAMP concentrations. Cyclic AMP 125-129 interleukin 1 beta Rattus norvegicus 32-41 10722803-12 2000 The alpha- and beta-adrenergic receptor blocker carvedilol normalized all functional parameters after 6 h and 72 h and prevented the development of LV hypertrophy that occurred after 72 h. The NE-induced increased expression of the mRNAs studied was either prevented (IL-6, IL-1 beta ) or attenuated (colligin, collagen I and III, ANP) by combined alpha- and beta-receptor blockade. Carvedilol 48-58 interleukin 1 beta Rattus norvegicus 274-283 10722808-3 2000 Incubation of the cultures with interleukin 1 beta (IL-1 beta; 10 ng/ml) caused a marked increase in nitrite production. Nitrites 101-108 interleukin 1 beta Rattus norvegicus 32-50 10722808-3 2000 Incubation of the cultures with interleukin 1 beta (IL-1 beta; 10 ng/ml) caused a marked increase in nitrite production. Nitrites 101-108 interleukin 1 beta Rattus norvegicus 52-61 10722808-4 2000 Although carvedilol alone showed no effect on nitrite accumulation, it significantly enhanced IL-1 beta-induced nitrite production by cardiac myocytes. Carvedilol 9-19 interleukin 1 beta Rattus norvegicus 94-103 10722808-4 2000 Although carvedilol alone showed no effect on nitrite accumulation, it significantly enhanced IL-1 beta-induced nitrite production by cardiac myocytes. Nitrites 112-119 interleukin 1 beta Rattus norvegicus 94-103 10722808-8 2000 Addition of isoproterenol significantly increased nitrite production by IL-1 beta-stimulated cardiac myocytes. Isoproterenol 12-25 interleukin 1 beta Rattus norvegicus 72-81 10722808-8 2000 Addition of isoproterenol significantly increased nitrite production by IL-1 beta-stimulated cardiac myocytes. Nitrites 50-57 interleukin 1 beta Rattus norvegicus 72-81 10722808-10 2000 These findings indicate that carvedilol increases NO synthesis in IL-1 beta-stimulated rat cardiac myocytes by a beta-adrenoceptor-independent mechanism. Carvedilol 29-39 interleukin 1 beta Rattus norvegicus 66-75 10678764-10 2000 These findings demonstrate that in the central nervous system, LPS increases IL-1beta production after activation of tyrosine kinase and NO synthase, and IL-1beta promotes prostaglandin production resulting in increased rectal temperature. Prostaglandins 172-185 interleukin 1 beta Rattus norvegicus 154-162 10741939-10 2000 Nimesulide and SC-236 decreased the enhanced colonic eicosanoid generation in acetic acid and iodoacetamide-induced colitis, and, in iodoacetamide-treated rats, nimesulide also decreased the elevated serum TNF-alpha and IL-1beta levels. nimesulide 0-10 interleukin 1 beta Rattus norvegicus 220-228 10741939-10 2000 Nimesulide and SC-236 decreased the enhanced colonic eicosanoid generation in acetic acid and iodoacetamide-induced colitis, and, in iodoacetamide-treated rats, nimesulide also decreased the elevated serum TNF-alpha and IL-1beta levels. 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide 15-21 interleukin 1 beta Rattus norvegicus 220-228 10741939-10 2000 Nimesulide and SC-236 decreased the enhanced colonic eicosanoid generation in acetic acid and iodoacetamide-induced colitis, and, in iodoacetamide-treated rats, nimesulide also decreased the elevated serum TNF-alpha and IL-1beta levels. nimesulide 161-171 interleukin 1 beta Rattus norvegicus 220-228 10958170-1 2000 Interleukin 1beta (IL-1) is cytotoxic to rat pancreatic beta-cells in vitro, and increased expression of IL-1 mRNA is found in the islets of Langerhans during development of diabetes in BB/Wor/Mol-BB2 (BB-DP) rats and NOD mice. bb-dp 202-207 interleukin 1 beta Rattus norvegicus 0-17 10863542-14 2000 In rat primary astrocytes p38 activation by the pro-inflammatory cytokine IL-1 beta, as well as by H2O2, was significantly suppressed by PBN. phenyl-N-tert-butylnitrone 137-140 interleukin 1 beta Rattus norvegicus 74-83 10623442-8 2000 The higher cellular ODC activity in IL-1beta treated RIN cells is associated with an increased cellular content of its enzymatic product putrescine, but not of putrescine-derived products such as polyamines and GABA. Putrescine 137-147 interleukin 1 beta Rattus norvegicus 36-44 10623442-8 2000 The higher cellular ODC activity in IL-1beta treated RIN cells is associated with an increased cellular content of its enzymatic product putrescine, but not of putrescine-derived products such as polyamines and GABA. Putrescine 160-170 interleukin 1 beta Rattus norvegicus 36-44 10793263-11 2000 In conclusion, a p50 and p65 NF-kappaB heterodimer binds to a reverse-NF-kappaB site on the rat iNOS promoter and contributes to iNOS induction by IL-1beta and IFN-gamma in RASMCs. rasmcs 173-179 interleukin 1 beta Rattus norvegicus 147-155 10671772-7 2000 Genistein (100 microM), a tyrosine kinase inhibitor, and GF109203X (2 microM), a protein kinase C inhibitor, inhibited the IL-1beta-induced activation of ERKs and JNKs. Genistein 0-9 interleukin 1 beta Rattus norvegicus 123-131 10671772-7 2000 Genistein (100 microM), a tyrosine kinase inhibitor, and GF109203X (2 microM), a protein kinase C inhibitor, inhibited the IL-1beta-induced activation of ERKs and JNKs. bisindolylmaleimide I 57-66 interleukin 1 beta Rattus norvegicus 123-131 10651889-2 2000 It is possible that this increase in IL-1beta might be a consequence of the age-related increase in reactive oxygen species production in hippocampal tissue. Reactive Oxygen Species 100-123 interleukin 1 beta Rattus norvegicus 37-45 11025357-2 2000 AIMS: This study was designed to investigate how water extracts (WE) of Hp applied on rat gastric mucosa affect gastric secretion and mucosal histamine concentration as well as the gene expression for histamine decarboxylase (HDC), the key enzyme converting histidine to histamine and for interleukin-1beta (IL-1beta), the important proinflammatory cytokine. Histamine 201-210 interleukin 1 beta Rattus norvegicus 289-306 11025357-2 2000 AIMS: This study was designed to investigate how water extracts (WE) of Hp applied on rat gastric mucosa affect gastric secretion and mucosal histamine concentration as well as the gene expression for histamine decarboxylase (HDC), the key enzyme converting histidine to histamine and for interleukin-1beta (IL-1beta), the important proinflammatory cytokine. Histamine 201-210 interleukin 1 beta Rattus norvegicus 308-316 10594923-2 2000 Exposure of neonatal rat cortical microglial cells to the exogenous cannabinoid delta(9)-tetrahydrocannabinol (THC) resulted in reduced amounts of lipopolysaccharide (LPS)-induced mRNAs for IL-1alpha, IL-1beta, IL-6, and TNF-alpha. Cannabinoids 68-79 interleukin 1 beta Rattus norvegicus 201-209 11469396-3 2000 By about 7 weeks of age, NIH-fed BBdp rats had lower plasma insulin and insulin/glucose ratio, lower insulin content of isolated islets, lower basal levels of NO but higher responsiveness of NO production to IL-1beta in cultured islets, and higher Con A response and biosynthetic activities in mesenteric lymphocytes than control rats fed the same diet. bbdp 33-37 interleukin 1 beta Rattus norvegicus 208-216 10594923-2 2000 Exposure of neonatal rat cortical microglial cells to the exogenous cannabinoid delta(9)-tetrahydrocannabinol (THC) resulted in reduced amounts of lipopolysaccharide (LPS)-induced mRNAs for IL-1alpha, IL-1beta, IL-6, and TNF-alpha. Dronabinol 80-109 interleukin 1 beta Rattus norvegicus 201-209 10594923-2 2000 Exposure of neonatal rat cortical microglial cells to the exogenous cannabinoid delta(9)-tetrahydrocannabinol (THC) resulted in reduced amounts of lipopolysaccharide (LPS)-induced mRNAs for IL-1alpha, IL-1beta, IL-6, and TNF-alpha. Dronabinol 111-114 interleukin 1 beta Rattus norvegicus 201-209 10778916-0 2000 Effects of pentoxifylline and nabumetone on the serum levels of IL-1beta and TNFalpha in rats with adjuvant arthritis. Pentoxifylline 11-25 interleukin 1 beta Rattus norvegicus 64-72 10778916-0 2000 Effects of pentoxifylline and nabumetone on the serum levels of IL-1beta and TNFalpha in rats with adjuvant arthritis. Nabumetone 30-40 interleukin 1 beta Rattus norvegicus 64-72 11199339-1 2000 Production of interleukin (IL)-1 beta, IL-6 and tumor necrosis factor (TNF)-alpha by rat corneal epithelial cells in response to lipopolysaccharide and phorbol-12-myristate-13-acetate (PMA) was tested. Tetradecanoylphorbol Acetate 152-183 interleukin 1 beta Rattus norvegicus 14-37 10601816-9 2000 Vehicle treated OB rats displayed a significant impairment in LPS-induced IL-1beta (54%) and TNF-alpha (70%) secretion compared to their sham operated controls, an effect that was potentiated following chronic desipramine treatment. Desipramine 210-221 interleukin 1 beta Rattus norvegicus 74-82 11200365-1 2000 BACKGROUND: Our previous results showed that in retinas from streptozotocin (STZ)-induced diabetic rats there is an increased level of interleukin-1beta (IL-1beta). Streptozocin 61-75 interleukin 1 beta Rattus norvegicus 135-152 11200365-1 2000 BACKGROUND: Our previous results showed that in retinas from streptozotocin (STZ)-induced diabetic rats there is an increased level of interleukin-1beta (IL-1beta). Streptozocin 61-75 interleukin 1 beta Rattus norvegicus 154-162 11200365-1 2000 BACKGROUND: Our previous results showed that in retinas from streptozotocin (STZ)-induced diabetic rats there is an increased level of interleukin-1beta (IL-1beta). Streptozocin 77-80 interleukin 1 beta Rattus norvegicus 135-152 11200365-1 2000 BACKGROUND: Our previous results showed that in retinas from streptozotocin (STZ)-induced diabetic rats there is an increased level of interleukin-1beta (IL-1beta). Streptozocin 77-80 interleukin 1 beta Rattus norvegicus 154-162 11200365-3 2000 AIMS: The aim of this work was to examine whether the administration of cyclosporin-A (Cs-A) to STZ-induced diabetic rats inhibits the synthesis of IL-1beta and the expression of the inducible proteins, iNOS and cyclo-oxygenase-2 (COX-2) in retinal cells, and whether the activity of these proteins contribute to BRB breakdown. Cyclosporine 72-85 interleukin 1 beta Rattus norvegicus 148-156 11200365-3 2000 AIMS: The aim of this work was to examine whether the administration of cyclosporin-A (Cs-A) to STZ-induced diabetic rats inhibits the synthesis of IL-1beta and the expression of the inducible proteins, iNOS and cyclo-oxygenase-2 (COX-2) in retinal cells, and whether the activity of these proteins contribute to BRB breakdown. Cyclosporine 87-91 interleukin 1 beta Rattus norvegicus 148-156 11200365-3 2000 AIMS: The aim of this work was to examine whether the administration of cyclosporin-A (Cs-A) to STZ-induced diabetic rats inhibits the synthesis of IL-1beta and the expression of the inducible proteins, iNOS and cyclo-oxygenase-2 (COX-2) in retinal cells, and whether the activity of these proteins contribute to BRB breakdown. Streptozocin 96-99 interleukin 1 beta Rattus norvegicus 148-156 11200365-7 2000 RESULTS AND DISCUSSION: Our results indicated that the levels of IL-1beta and NO in retinas from Cs-A-treated diabetic rats are significantly reduced, as compared to that in non-treated diabetic rats. Cyclosporine 97-101 interleukin 1 beta Rattus norvegicus 65-73 10620188-2 2000 BACKGROUND: High-output levels of nitric oxide (NO) are produced by rat mesangial cells (MCs) in response to proinflammatory cytokines such as interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the inducible isoform of NO synthase (iNOS). Nitric Oxide 34-46 interleukin 1 beta Rattus norvegicus 143-160 10620188-2 2000 BACKGROUND: High-output levels of nitric oxide (NO) are produced by rat mesangial cells (MCs) in response to proinflammatory cytokines such as interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) by the inducible isoform of NO synthase (iNOS). Nitric Oxide 34-46 interleukin 1 beta Rattus norvegicus 162-170 10620188-6 2000 Using the NO donors S-Nitroso-N-acetyl-D,L-penicillamine (SNAP) and DETA-NONOate, we found strong inhibitory effects of NO mainly on the IL-1beta-induced MMP-9 mRNA levels. snap 20-56 interleukin 1 beta Rattus norvegicus 137-145 10620188-6 2000 Using the NO donors S-Nitroso-N-acetyl-D,L-penicillamine (SNAP) and DETA-NONOate, we found strong inhibitory effects of NO mainly on the IL-1beta-induced MMP-9 mRNA levels. snap 58-62 interleukin 1 beta Rattus norvegicus 137-145 10620188-6 2000 Using the NO donors S-Nitroso-N-acetyl-D,L-penicillamine (SNAP) and DETA-NONOate, we found strong inhibitory effects of NO mainly on the IL-1beta-induced MMP-9 mRNA levels. 2,2'-(hydroxynitrosohydrazono)bis-ethanamine 68-80 interleukin 1 beta Rattus norvegicus 137-145 10601816-10 2000 Furthermore, sham animals that were chronically treated with desipramine displayed decreases in LPS-provoked IL-1beta (51%) and TNF-alpha (49%) secretion compared to vehicle treated counterparts. Desipramine 61-72 interleukin 1 beta Rattus norvegicus 109-117 10631129-4 2000 Hepatic concentrations of interleukin (IL)-1beta and cytokine-induced neutrophil chemoattractant (CINC), but not of tumor necrosis factor-alpha or IL-6, were elevated in young rats treated with Cd. Cadmium 194-196 interleukin 1 beta Rattus norvegicus 26-48 11455340-6 2000 RESULTS: In the rats treated with oct in comparison to the untreated group the reduction of the clinical signs, a decrease of the body weight fall, inhibition of the thymus weight fall, the lower spleen"s weight, an increase of the thymus cellularity and an increase of the IL-1 beta level in serum were found. Octreotide 34-37 interleukin 1 beta Rattus norvegicus 274-283 11455340-10 2000 The rats treated with dx and oct jointly showed in comparison with dx alone a weaker reduction of the clinical signs, lower thymus weight fall, an increase of the IL-1 beta level in serum, without the significant influence on the other parameters. Octreotide 29-32 interleukin 1 beta Rattus norvegicus 163-172 11113345-6 2000 wt dexran in the rat CNS after intracerebroventricular administration to model interleukin-1beta release from choroid plexus. dexran 3-9 interleukin 1 beta Rattus norvegicus 79-96 27414053-6 2000 IL-1beta increased reactive oxygen species production in vitro, suggesting that it may also exert this effect in vivo. Reactive Oxygen Species 19-42 interleukin 1 beta Rattus norvegicus 0-8 10631129-5 2000 In old rats, however, the increase in IL-1beta produced by Cd was not statistically significant and the increase in CINC was much lower than in young-adult rats. Cadmium 59-61 interleukin 1 beta Rattus norvegicus 38-46 10624806-1 1999 Previous in vitro studies showed that rat hypothalamic explants release interleukin-1beta (IL-1beta); such release is significantly increased by several stimuli including 56 mM KCl and NO-donors in 20-min experiments. Potassium Chloride 177-180 interleukin 1 beta Rattus norvegicus 72-89 10631129-8 2000 The results suggest that (1) Kupffer cell activation is essential for inflammatory liver damage from Cd, (2) IL-1beta and CINC are important mediators of the inflammatory response induced by Cd, and (3) the attenuation of Cd-induced liver injury in senescent rats is caused by an impairment in Kupffer cell activation, leading to a lower production of CINC and less inflammatory liver injury. Cadmium 191-193 interleukin 1 beta Rattus norvegicus 109-117 10631129-8 2000 The results suggest that (1) Kupffer cell activation is essential for inflammatory liver damage from Cd, (2) IL-1beta and CINC are important mediators of the inflammatory response induced by Cd, and (3) the attenuation of Cd-induced liver injury in senescent rats is caused by an impairment in Kupffer cell activation, leading to a lower production of CINC and less inflammatory liver injury. Cadmium 191-193 interleukin 1 beta Rattus norvegicus 109-117 10631129-8 2000 The results suggest that (1) Kupffer cell activation is essential for inflammatory liver damage from Cd, (2) IL-1beta and CINC are important mediators of the inflammatory response induced by Cd, and (3) the attenuation of Cd-induced liver injury in senescent rats is caused by an impairment in Kupffer cell activation, leading to a lower production of CINC and less inflammatory liver injury. Zinc 352-356 interleukin 1 beta Rattus norvegicus 109-117 10593906-1 1999 Interleukin 1beta (IL-1beta) induces expression of the inducible nitric-oxide synthase (iNOS) with concomitant release of nitric oxide (NO) from glomerular mesangial cells. Nitric Oxide 122-134 interleukin 1 beta Rattus norvegicus 0-17 10593906-1 1999 Interleukin 1beta (IL-1beta) induces expression of the inducible nitric-oxide synthase (iNOS) with concomitant release of nitric oxide (NO) from glomerular mesangial cells. Nitric Oxide 122-134 interleukin 1 beta Rattus norvegicus 19-27 10624806-1 1999 Previous in vitro studies showed that rat hypothalamic explants release interleukin-1beta (IL-1beta); such release is significantly increased by several stimuli including 56 mM KCl and NO-donors in 20-min experiments. Potassium Chloride 177-180 interleukin 1 beta Rattus norvegicus 91-99 10579332-7 1999 The effect of ceramide was mimicked by interleukin-1beta, a cytokine highly expressed in the pineal that is known to activate the sphingomyelin pathway. Ceramides 14-22 interleukin 1 beta Rattus norvegicus 39-56 10571249-3 1999 We found that treatment of mesangial cells with the biologically active phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate inhibited IL-1beta induction of sPLA2-IIA mRNA, protein, and activity, whereas the inactive compound 4alpha-phorbol 12,13-didecanoate was without effect. Tetradecanoylphorbol Acetate 72-103 interleukin 1 beta Rattus norvegicus 149-157 10571249-3 1999 We found that treatment of mesangial cells with the biologically active phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate inhibited IL-1beta induction of sPLA2-IIA mRNA, protein, and activity, whereas the inactive compound 4alpha-phorbol 12,13-didecanoate was without effect. Tetradecanoylphorbol Acetate 105-108 interleukin 1 beta Rattus norvegicus 149-157 10571249-3 1999 We found that treatment of mesangial cells with the biologically active phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate inhibited IL-1beta induction of sPLA2-IIA mRNA, protein, and activity, whereas the inactive compound 4alpha-phorbol 12,13-didecanoate was without effect. Phorbol 12,13-Dibutyrate 114-138 interleukin 1 beta Rattus norvegicus 149-157 10571249-3 1999 We found that treatment of mesangial cells with the biologically active phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate inhibited IL-1beta induction of sPLA2-IIA mRNA, protein, and activity, whereas the inactive compound 4alpha-phorbol 12,13-didecanoate was without effect. phorbol-12,13-didecanoate 240-272 interleukin 1 beta Rattus norvegicus 149-157 10571249-5 1999 Only after down-regulation of PKC-epsilon isoenzyme by 24-hr preincubation with PMA were we able to reconstitute the IL-1beta-induced sPLA2-IIA expression. Tetradecanoylphorbol Acetate 80-83 interleukin 1 beta Rattus norvegicus 117-125 10579332-7 1999 The effect of ceramide was mimicked by interleukin-1beta, a cytokine highly expressed in the pineal that is known to activate the sphingomyelin pathway. Sphingomyelins 130-143 interleukin 1 beta Rattus norvegicus 39-56 10580420-4 1999 After exposure to interleukin (IL)-1beta, both of the insulin-producing phenotypes were significantly more susceptible to toxic effects than their glucagon-producing counterparts. Glucagon 147-155 interleukin 1 beta Rattus norvegicus 18-40 10579318-6 1999 Radioiodine-labeled IL-1beta appeared in blood as early as 5 min, and by phamacokinetic analysis was found to be transferred from the brain at a rate greater than 2% of brain content per min(-1). Iodine-131 0-11 interleukin 1 beta Rattus norvegicus 20-28 10640438-10 1999 Inhibitors of protein kinase C (PKC) (Ro318220, GF109203X) and the ERK cascade (PD98059) attenuated the increase in c-Jun induced by IL-1 beta, but LY294002 (an inhibitor of phosphatidylinositol 3" kinase) and SB203580 (an inhibitor of p38-MAPK, which also inhibits certain JNK isoforms) had no effect. bisindolylmaleimide I 48-57 interleukin 1 beta Rattus norvegicus 133-142 10586942-8 1999 Clodronate-LIP treatment prevented allograft rejection and strongly decreased the levels of IL-1beta, IL-1RA, IL-2, IL-4, IL-6, IL-10, IFN-gamma, TNF-beta/LT, MCP-1, and MIP-2 mRNA in grafts and IL-1 beta, IL-2, IL-4, IL-6, and IFN-gamma mRNA in rims. Clodronic Acid 0-10 interleukin 1 beta Rattus norvegicus 92-100 10586942-8 1999 Clodronate-LIP treatment prevented allograft rejection and strongly decreased the levels of IL-1beta, IL-1RA, IL-2, IL-4, IL-6, IL-10, IFN-gamma, TNF-beta/LT, MCP-1, and MIP-2 mRNA in grafts and IL-1 beta, IL-2, IL-4, IL-6, and IFN-gamma mRNA in rims. Clodronic Acid 0-10 interleukin 1 beta Rattus norvegicus 195-204 10737222-0 1999 Vitamin E suppresses the induction of reactive oxygen species release by lipopolysaccharide, interleukin-1beta and tumor necrosis factor-alpha in rat alveolar macrophages. Vitamin E 0-9 interleukin 1 beta Rattus norvegicus 93-142 10737222-0 1999 Vitamin E suppresses the induction of reactive oxygen species release by lipopolysaccharide, interleukin-1beta and tumor necrosis factor-alpha in rat alveolar macrophages. Reactive Oxygen Species 38-61 interleukin 1 beta Rattus norvegicus 93-142 10640438-10 1999 Inhibitors of protein kinase C (PKC) (Ro318220, GF109203X) and the ERK cascade (PD98059) attenuated the increase in c-Jun induced by IL-1 beta, but LY294002 (an inhibitor of phosphatidylinositol 3" kinase) and SB203580 (an inhibitor of p38-MAPK, which also inhibits certain JNK isoforms) had no effect. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 80-87 interleukin 1 beta Rattus norvegicus 133-142 10602391-6 1999 It was found that both TNF-alpha and IL1-beta were significantly elevated in saline/TAA receivers (P<0.01) when compared to NAC/TAA receivers. Sodium Chloride 77-83 interleukin 1 beta Rattus norvegicus 37-45 10619394-5 1999 Treatment with indomethacin was without significant effect on the early (1 h) response to IL-1beta; however, it led to complete and highly significant dose-dependent blockade of the late (48 h) response to IL-1beta as assessed in terms of PGS-2 transcripts, proteins and activity. Indomethacin 15-27 interleukin 1 beta Rattus norvegicus 90-98 10619394-5 1999 Treatment with indomethacin was without significant effect on the early (1 h) response to IL-1beta; however, it led to complete and highly significant dose-dependent blockade of the late (48 h) response to IL-1beta as assessed in terms of PGS-2 transcripts, proteins and activity. Indomethacin 15-27 interleukin 1 beta Rattus norvegicus 206-214 10619394-6 1999 The addition of PGE2 to cells augmented the ability of IL-1beta to upregulate PGS-2 transcripts. Dinoprostone 16-20 interleukin 1 beta Rattus norvegicus 55-63 10619394-7 1999 Moreover, the addition of PGE2 to indomethacin-treated cells all but reversed the ability of indomethacin to suppress the IL-1beta effect at both the PGS-2 transcript and protein levels. Dinoprostone 26-30 interleukin 1 beta Rattus norvegicus 122-130 10619394-7 1999 Moreover, the addition of PGE2 to indomethacin-treated cells all but reversed the ability of indomethacin to suppress the IL-1beta effect at both the PGS-2 transcript and protein levels. Indomethacin 34-46 interleukin 1 beta Rattus norvegicus 122-130 10619394-7 1999 Moreover, the addition of PGE2 to indomethacin-treated cells all but reversed the ability of indomethacin to suppress the IL-1beta effect at both the PGS-2 transcript and protein levels. Indomethacin 93-105 interleukin 1 beta Rattus norvegicus 122-130 10619394-8 1999 The upregulation by IL-1 of IL-1beta, IL-1R and IL-1RA transcripts was similarly inhibited by indomethacin. Indomethacin 94-106 interleukin 1 beta Rattus norvegicus 28-36 10533051-7 1999 Pretreatment with PAF antagonist BN50730 blocked induction of COX-2 mRNA by 2-hour IL-1beta treatment, and 2-hour treatment with the PAF analog mcPAF mimicked the effects of IL-1beta on COX-2 mRNA levels. BN 50730 33-40 interleukin 1 beta Rattus norvegicus 83-91 10517906-1 1999 BACKGROUND: A previous study showed that the glucocorticoid dexamethasone, at doses of 100 microg/kg and above, inhibited leucocyte adhesion to rat mesenteric postcapillary venules activated with interleukin 1beta (IL-1beta), as assessed by videomicroscopy. Dexamethasone 60-73 interleukin 1 beta Rattus norvegicus 196-213 10517906-1 1999 BACKGROUND: A previous study showed that the glucocorticoid dexamethasone, at doses of 100 microg/kg and above, inhibited leucocyte adhesion to rat mesenteric postcapillary venules activated with interleukin 1beta (IL-1beta), as assessed by videomicroscopy. Dexamethasone 60-73 interleukin 1 beta Rattus norvegicus 215-223 10517906-6 1999 RESULTS: Dexamethasone greatly reduced IL-1beta induced leucocyte adhesion, endothelial expression of ICAM-1 in the postcapillary venule, and release of the mast cell derived chemokine KC. Dexamethasone 9-22 interleukin 1 beta Rattus norvegicus 39-47 10591026-6 1999 As for the morphological changes of MCs, IL-1 beta induced the star-shaped MC hypertrophy characterized by elongation and pointed edges only in the MC-NMC coculture, while ET-1 induced the MC hypertrophy characterized by shapes of squares, triangles or circles in both cultures. mc-nmc 148-154 interleukin 1 beta Rattus norvegicus 41-50 10537081-4 1999 The effect of IL-1beta was Ca(2+)-dependent and significantly inhibited by 100 ng/ml IL-1 receptor-specific antagonist (IL-1r antagonist), cyclooxygenase (COX) inhibitors such as 0.1 mM aspirin, 1 microg/ml indomethacin, and 1 microM NS-398 (specific for COX-2), and 1 microM dexamethasone. Aspirin 186-193 interleukin 1 beta Rattus norvegicus 14-22 10537081-4 1999 The effect of IL-1beta was Ca(2+)-dependent and significantly inhibited by 100 ng/ml IL-1 receptor-specific antagonist (IL-1r antagonist), cyclooxygenase (COX) inhibitors such as 0.1 mM aspirin, 1 microg/ml indomethacin, and 1 microM NS-398 (specific for COX-2), and 1 microM dexamethasone. Indomethacin 207-219 interleukin 1 beta Rattus norvegicus 14-22 10537081-4 1999 The effect of IL-1beta was Ca(2+)-dependent and significantly inhibited by 100 ng/ml IL-1 receptor-specific antagonist (IL-1r antagonist), cyclooxygenase (COX) inhibitors such as 0.1 mM aspirin, 1 microg/ml indomethacin, and 1 microM NS-398 (specific for COX-2), and 1 microM dexamethasone. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 234-240 interleukin 1 beta Rattus norvegicus 14-22 10537081-4 1999 The effect of IL-1beta was Ca(2+)-dependent and significantly inhibited by 100 ng/ml IL-1 receptor-specific antagonist (IL-1r antagonist), cyclooxygenase (COX) inhibitors such as 0.1 mM aspirin, 1 microg/ml indomethacin, and 1 microM NS-398 (specific for COX-2), and 1 microM dexamethasone. Dexamethasone 276-289 interleukin 1 beta Rattus norvegicus 14-22 10537081-5 1999 Furthermore, a 1-h incubation with IL-1beta markedly increased the inducible COX-2 mRNA level, which was inhibited by an IL-1r antagonist and dexamethasone, whereas IL-1beta showed no effect on the level of constitutive COX-1 mRNA. Dexamethasone 142-155 interleukin 1 beta Rattus norvegicus 35-43 10537081-6 1999 These observations indicated that IL-1beta induced the release of SP from the DRG cells via specific IL-1 receptors, the mechanism of which might involve prostanoid systems produced by COX-2. Prostaglandins 154-164 interleukin 1 beta Rattus norvegicus 34-42 10748917-0 1999 L-arginine transport in retinas from streptozotocin diabetic rats: correlation with the level of IL-1 beta and NO synthase activity. Arginine 0-10 interleukin 1 beta Rattus norvegicus 97-106 10616913-8 1999 These results suggest that there are at least two different intracellular signaling pathways of LPS-induced microglial activation; one for early release of TNF-alpha and IL-1beta sensitive to dibutyryl-cAMP and the other for late release of IL-6 and NO insensitive to dibutyryl-cAMP. Bucladesine 192-206 interleukin 1 beta Rattus norvegicus 170-178 10518027-1 1999 Exposure of RINm5F cells to interleukin-1beta and to several chemical NO donors such as sodium nitroprusside (SNP), SIN-1 and SNAP induce apoptotic events such as the release of cytochrome c from mitochondria, caspase 3 activation, Bcl-2 downregulation and DNA fragmentation. Nitroprusside 88-108 interleukin 1 beta Rattus norvegicus 28-45 10616913-7 1999 The addition of dibutyryl cAMP markedly inhibited the release of TNF-alpha and IL-1beta, but not IL-6 and NO at all. Cyclic AMP 26-30 interleukin 1 beta Rattus norvegicus 79-87 10532951-4 1999 Similarly, incubation of NRVMs with IL-1beta and IFNgamma for 48 hours resulted in an increase in iNOS expression, nitrite production, and programmed cell death. Nitrites 115-122 interleukin 1 beta Rattus norvegicus 36-44 10748917-2 1999 IL-1 beta induces the expression of the inducible isoform of NO synthase (iNOS), which use L-arginine as substrate to overproduce NO. Arginine 91-101 interleukin 1 beta Rattus norvegicus 0-9 10748917-4 1999 In this work, we found an increased level of IL-1 beta in retinas from streptozotocin-induced (STZ) diabetic rats. Streptozocin 71-85 interleukin 1 beta Rattus norvegicus 45-54 10748917-4 1999 In this work, we found an increased level of IL-1 beta in retinas from streptozotocin-induced (STZ) diabetic rats. Streptozocin 95-98 interleukin 1 beta Rattus norvegicus 45-54 10525660-6 1999 RESULTS: Interleukin-1beta increased the expression of adenine nucleotide translocator-1, phospholipase D-1 and cytokine-induced neutrophil chemoattractant-1 and decreased expression of the protein tyrosine phosphatase-like protein IA-2. Adenine Nucleotides 55-73 interleukin 1 beta Rattus norvegicus 9-26 10522854-7 1999 CONCLUSIONS: These results suggest that cholesterol-containing cationic liposomes alone may have a beneficial effect in modulating the hypermetabolic response after burn injury by decreasing type 1 acute-phase proteins and the expression of the proinflammatory cytokines interleukin 1beta and tumor necrosis factor alpha. Cholesterol 40-51 interleukin 1 beta Rattus norvegicus 271-320 10524680-0 1999 Cartilage protection by nitric oxide synthase inhibitors after intraarticular injection of interleukin-1beta in rats. Nitric Oxide 24-36 interleukin 1 beta Rattus norvegicus 91-108 10516205-1 1999 We have previously reported that interleukin-1beta (IL-1beta) alone induced nitric oxide (NO) production by neonatal rat cardiac myocytes (CM). Nitric Oxide 76-88 interleukin 1 beta Rattus norvegicus 33-50 10516205-1 1999 We have previously reported that interleukin-1beta (IL-1beta) alone induced nitric oxide (NO) production by neonatal rat cardiac myocytes (CM). Nitric Oxide 76-88 interleukin 1 beta Rattus norvegicus 52-60 10516205-5 1999 TNF-alpha enhancement of IL-1beta-induced NO(-)(2) production was blocked by PD-98059, a selective mitogen-activated protein (MAP) kinase kinase inhibitor, but not calphostin C (Cal C), a protein kinase C inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 77-85 interleukin 1 beta Rattus norvegicus 25-33 10523329-0 1999 N-acetyl-L-cysteine enhances interleukin-1beta-induced nitric oxide synthase expression. Acetylcysteine 0-19 interleukin 1 beta Rattus norvegicus 29-46 10523329-1 1999 The effect of N-acetyl-L-cysteine on interleukin-1beta-induced nitric oxide synthase expression was studied in rat vascular smooth muscle cells to determine if the reduction/oxidation state would modulate cytokine-induced changes. Acetylcysteine 14-33 interleukin 1 beta Rattus norvegicus 37-54 10523329-7 1999 Nitrite accumulation was higher by the cells treated with interleukin-1beta combined with either interferon-gamma or tumor necrosis factor-alpha compared with those treated with interleukin-1beta alone. Nitrites 0-7 interleukin 1 beta Rattus norvegicus 58-75 10523329-2 1999 Interleukin-1beta induced the production of nitrite, a stable metabolite of nitric oxide in a time- and dose-dependent manner. Nitrites 44-51 interleukin 1 beta Rattus norvegicus 0-17 10523329-7 1999 Nitrite accumulation was higher by the cells treated with interleukin-1beta combined with either interferon-gamma or tumor necrosis factor-alpha compared with those treated with interleukin-1beta alone. Nitrites 0-7 interleukin 1 beta Rattus norvegicus 178-195 10523329-8 1999 N-Acetyl-L-cysteine upregulated nitrite production and inducible nitric oxide synthase expression induced by combination treatment with interleukin-1beta and either interferon-gamma or tumor necrosis factor-alpha. Acetylcysteine 0-19 interleukin 1 beta Rattus norvegicus 136-153 10523329-2 1999 Interleukin-1beta induced the production of nitrite, a stable metabolite of nitric oxide in a time- and dose-dependent manner. Nitric Oxide 76-88 interleukin 1 beta Rattus norvegicus 0-17 10523329-8 1999 N-Acetyl-L-cysteine upregulated nitrite production and inducible nitric oxide synthase expression induced by combination treatment with interleukin-1beta and either interferon-gamma or tumor necrosis factor-alpha. Nitrites 32-39 interleukin 1 beta Rattus norvegicus 136-153 10523329-5 1999 Northern and Western blot analyses revealed that the upregulation of interleukin-1beta-induced nitric oxide production by N-acetyl-L-cysteine resulted from an enhanced expression of inducible nitric oxide synthase. Nitric Oxide 95-107 interleukin 1 beta Rattus norvegicus 69-86 10523329-5 1999 Northern and Western blot analyses revealed that the upregulation of interleukin-1beta-induced nitric oxide production by N-acetyl-L-cysteine resulted from an enhanced expression of inducible nitric oxide synthase. Acetylcysteine 122-141 interleukin 1 beta Rattus norvegicus 69-86 10501189-7 1999 In addition, 17beta-estradiol (10 microM) and sodium salicylate (10 mM) were able to attenuate the increase in interleukin-1beta levels following exposure to 25 microM A beta. Sodium Salicylate 46-63 interleukin 1 beta Rattus norvegicus 111-128 12609461-0 1999 Differential effect of a single high dose of the tricyclic antidepressant imipramine on interleukin-1beta and tumor necrosis factor-alpha secretion following an in vivo lipopolysaccharide challenge in rats. Imipramine 74-84 interleukin 1 beta Rattus norvegicus 88-137 12609461-9 1999 In conclusion, although IL-1beta and TNF-alpha are both macrophage-derived proinflammatory cytokines, the present study demonstrates a differential sensitivity of these cytokines to the suppressive effects of the TCA imipramine. tca imipramine 213-227 interleukin 1 beta Rattus norvegicus 24-32 10501189-7 1999 In addition, 17beta-estradiol (10 microM) and sodium salicylate (10 mM) were able to attenuate the increase in interleukin-1beta levels following exposure to 25 microM A beta. Estradiol 13-29 interleukin 1 beta Rattus norvegicus 111-128 10477620-5 1999 Curcumin inhibited IL-1 beta-mediated ICAM-1 and IL-8 gene expression in IEC-6, HT-29, and Caco-2 cells. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 19-28 10529137-6 1999 The concentration of IL-1beta was lower in the presence of 40 mg HA (251.0+/-61.4 pg/ml, n = 4) or 40 mg CMC (168.2+/-43.5 pg/ml, n = 4; p < 0.05) than in saline (403.0+/-60.5 pg/ml, n = 4). Carboxymethylcellulose Sodium 105-108 interleukin 1 beta Rattus norvegicus 21-29 10529137-6 1999 The concentration of IL-1beta was lower in the presence of 40 mg HA (251.0+/-61.4 pg/ml, n = 4) or 40 mg CMC (168.2+/-43.5 pg/ml, n = 4; p < 0.05) than in saline (403.0+/-60.5 pg/ml, n = 4). Sodium Chloride 158-164 interleukin 1 beta Rattus norvegicus 21-29 10505651-0 1999 Astrocytes rather than neurones mediate interleukin-1beta dependent nitric oxide and superoxide radical release in primary hypothalamic rat cell cultures. Nitric Oxide 68-80 interleukin 1 beta Rattus norvegicus 40-57 10505651-3 1999 We present evidence that under interleukin-1beta (IL-1beta) stimulation hypothalamic astrocytes rather than neurones release nitric oxide. Nitric Oxide 125-137 interleukin 1 beta Rattus norvegicus 31-48 10505651-3 1999 We present evidence that under interleukin-1beta (IL-1beta) stimulation hypothalamic astrocytes rather than neurones release nitric oxide. Nitric Oxide 125-137 interleukin 1 beta Rattus norvegicus 50-58 10505651-4 1999 Under L-arginine deprivation and IL-1beta stimulation a concentration-dependent release of superoxide was also observed, which was inhibited in the presence of nitric oxide synthase inhibitor nitro-L-argininemethyl-ester. Arginine 6-16 interleukin 1 beta Rattus norvegicus 33-41 10505651-4 1999 Under L-arginine deprivation and IL-1beta stimulation a concentration-dependent release of superoxide was also observed, which was inhibited in the presence of nitric oxide synthase inhibitor nitro-L-argininemethyl-ester. Superoxides 91-101 interleukin 1 beta Rattus norvegicus 33-41 10505651-4 1999 Under L-arginine deprivation and IL-1beta stimulation a concentration-dependent release of superoxide was also observed, which was inhibited in the presence of nitric oxide synthase inhibitor nitro-L-argininemethyl-ester. nitric 160-166 interleukin 1 beta Rattus norvegicus 33-41 10505651-4 1999 Under L-arginine deprivation and IL-1beta stimulation a concentration-dependent release of superoxide was also observed, which was inhibited in the presence of nitric oxide synthase inhibitor nitro-L-argininemethyl-ester. nitro-l-argininemethyl-ester 192-220 interleukin 1 beta Rattus norvegicus 33-41 10526094-7 1999 Treatment of astrocytes with ACT, IL-1beta, or S100beta resulted in glial activation, as assessed by reactive morphology, upregulation of IL-1beta, and production of inducible nitric oxide synthase and nitric oxide. Nitric Oxide 176-188 interleukin 1 beta Rattus norvegicus 34-42 10507556-5 1999 The IL-1beta-induced responses were blocked by picrotoxin (100 microM) but not by bicuculline (20 microM). Picrotoxin 47-57 interleukin 1 beta Rattus norvegicus 4-12 10629862-6 1999 Thus we suggest that the formation of heterodimer p50.p65 from inactive trimer p50.p65.I kappa B alpha, particularly, proteolytic degradation and dissociation of I kappa B alpha from p50.p65 are a critical phase in NF-kappa B activation during LPS-induced iNOS and IL-1 beta-induced CINC expression in astroglial cells. Zinc 283-287 interleukin 1 beta Rattus norvegicus 265-274 10580845-2 1999 Prior reports from this laboratory have demonstrated that these cells produce IL-1alpha and IL-1beta mRNAs in response to the hormonal action of serotonin. Serotonin 145-154 interleukin 1 beta Rattus norvegicus 92-100 10507556-6 1999 Imidazole-4-acetic acid (14AA, 100 microM), a GABA(C) receptor antagonist, reduced the IL-1beta-induced responses. imidazoleacetic acid 0-23 interleukin 1 beta Rattus norvegicus 87-95 10507556-6 1999 Imidazole-4-acetic acid (14AA, 100 microM), a GABA(C) receptor antagonist, reduced the IL-1beta-induced responses. 14aa 25-29 interleukin 1 beta Rattus norvegicus 87-95 10498857-0 1999 Interleukin-1beta (IL-1beta) inhibition: a possible mechanism for the anti-inflammatory potency of liposomally conjugated methotrexate formulations in arthritis. Methotrexate 122-134 interleukin 1 beta Rattus norvegicus 0-17 10498857-0 1999 Interleukin-1beta (IL-1beta) inhibition: a possible mechanism for the anti-inflammatory potency of liposomally conjugated methotrexate formulations in arthritis. Methotrexate 122-134 interleukin 1 beta Rattus norvegicus 19-27 10493213-12 1999 Increased plasma levels of interleukin-1beta, tissue necrosis factor-alpha and interleukin-6 were suppressed by prednisolone but not by heparin, and there were significant correlations between plasma levels of TAT and cytokines. Prednisolone 112-124 interleukin 1 beta Rattus norvegicus 27-44 10496176-0 1999 Fetal alcohol exposure attenuates interleukin-1beta-induced fever: neuroimmune mechanisms. Alcohols 6-13 interleukin 1 beta Rattus norvegicus 34-51 10510443-3 1999 Cyclosporin A and FK506 (at 1 microM) also significantly inhibited nitrite production induced by recombinant murine interferon-gamma (rIFNgamma) and recombinant murine interleukin-1beta (rIL-1beta) in J774 and VSMC, respectively. Cyclosporine 0-13 interleukin 1 beta Rattus norvegicus 187-196 10510443-3 1999 Cyclosporin A and FK506 (at 1 microM) also significantly inhibited nitrite production induced by recombinant murine interferon-gamma (rIFNgamma) and recombinant murine interleukin-1beta (rIL-1beta) in J774 and VSMC, respectively. Tacrolimus 18-23 interleukin 1 beta Rattus norvegicus 187-196 10510443-3 1999 Cyclosporin A and FK506 (at 1 microM) also significantly inhibited nitrite production induced by recombinant murine interferon-gamma (rIFNgamma) and recombinant murine interleukin-1beta (rIL-1beta) in J774 and VSMC, respectively. Nitrites 67-74 interleukin 1 beta Rattus norvegicus 187-196 10453038-7 1999 The macrolides also reduced IgG-ICx-induced release of IL-1beta and TNF-alpha, but did not alter the release of NO induced by exogenously added IL-1beta and TNF-alpha. Macrolides 4-14 interleukin 1 beta Rattus norvegicus 55-63 10453038-7 1999 The macrolides also reduced IgG-ICx-induced release of IL-1beta and TNF-alpha, but did not alter the release of NO induced by exogenously added IL-1beta and TNF-alpha. Methyl N-[(5z)-6-({[4-(4-Iodobenzyl)phenyl]carbonyl}amino)hex-5-Enoyl]glycinate 32-35 interleukin 1 beta Rattus norvegicus 55-63 10498857-4 1999 At non-toxic dose, both MTX-EPC and MTX-PEG inhibited the lipopolysaccharide (LPS) induced release of IL-1beta from activated rat peritoneal macrophages (rPMPhi) in a dose and time dependent manner. mtx-epc 24-31 interleukin 1 beta Rattus norvegicus 102-110 10498857-4 1999 At non-toxic dose, both MTX-EPC and MTX-PEG inhibited the lipopolysaccharide (LPS) induced release of IL-1beta from activated rat peritoneal macrophages (rPMPhi) in a dose and time dependent manner. mtx-peg 36-43 interleukin 1 beta Rattus norvegicus 102-110 10498857-7 1999 ), and at equivalent doses, both free MTX (500 microg) and MTX-EPC inhibited the LPS induced rise in plasma IL-1beta levels observed in MTX-PEG and saline treated rats. Methotrexate 38-41 interleukin 1 beta Rattus norvegicus 108-116 10498857-7 1999 ), and at equivalent doses, both free MTX (500 microg) and MTX-EPC inhibited the LPS induced rise in plasma IL-1beta levels observed in MTX-PEG and saline treated rats. Methotrexate 59-62 interleukin 1 beta Rattus norvegicus 108-116 10498857-7 1999 ), and at equivalent doses, both free MTX (500 microg) and MTX-EPC inhibited the LPS induced rise in plasma IL-1beta levels observed in MTX-PEG and saline treated rats. mtx-peg 136-143 interleukin 1 beta Rattus norvegicus 108-116 10464131-7 1999 NO-mesalamine inhibited IL-1beta and IFN-gamma release and caspase 1 activity in splenocytes; such effects were not found in the inflamed colon. no-mesalamine 0-13 interleukin 1 beta Rattus norvegicus 24-32 10496176-1 1999 Central mechanisms for the attenuating effects of fetal alcohol exposure (FAE) on interleukin-1beta (IL-1beta)-induced fever were studied in adult male offspring of dams fed a liquid diet supplemented with ethanol (E), in pair-fed (P) control and in normal (N) offspring. Alcohols 56-63 interleukin 1 beta Rattus norvegicus 82-99 10444523-2 1999 Exposure of RPMCs for 24 h to either crocidolite or chrysotile fibers (1.25-10 microgram/cm(2)) increased the adhesion of RPLs to RPMCs in a dose-dependent fashion, an effect that was potentiated by interleukin-1beta. Asbestos, Crocidolite 37-48 interleukin 1 beta Rattus norvegicus 199-216 10580367-3 1999 administered interleukin-1beta (IL-1beta) (100 ng/animal) slightly, but significantly, elevated the plasma level of noradrenaline (NA), but not the level of adrenaline (Ad). Norepinephrine 116-129 interleukin 1 beta Rattus norvegicus 13-30 10580367-3 1999 administered interleukin-1beta (IL-1beta) (100 ng/animal) slightly, but significantly, elevated the plasma level of noradrenaline (NA), but not the level of adrenaline (Ad). Norepinephrine 116-129 interleukin 1 beta Rattus norvegicus 32-40 10580367-3 1999 administered interleukin-1beta (IL-1beta) (100 ng/animal) slightly, but significantly, elevated the plasma level of noradrenaline (NA), but not the level of adrenaline (Ad). Epinephrine 119-129 interleukin 1 beta Rattus norvegicus 13-30 10580367-3 1999 administered interleukin-1beta (IL-1beta) (100 ng/animal) slightly, but significantly, elevated the plasma level of noradrenaline (NA), but not the level of adrenaline (Ad). Epinephrine 119-129 interleukin 1 beta Rattus norvegicus 32-40 10580367-8 1999 Furthermore, the IL-1beta-induced elevations of plasma catecholamines in these pinealectomized animals were attenuated by i.c.v. Catecholamines 55-69 interleukin 1 beta Rattus norvegicus 17-25 12935482-0 1999 Changes in mRNAs of inducible nitric oxide synthase and interleukin-1 beta in the liver, kidney and lung tissues of rats acutely exposed to paraquat. Paraquat 140-148 interleukin 1 beta Rattus norvegicus 56-74 12935482-4 1999 In this study, we have investigated whether mRNAs of iNOS and IL-1 beta are affected in rat liver, kidney and lung tissues by exposure to non-lethal and lethal doses of PQ. Paraquat 169-171 interleukin 1 beta Rattus norvegicus 62-71 12935482-9 1999 These data suggest that acute lethal poisoning and non-lethal poisoning by PQ undergo different mechanisms of action of NO and IL-1 beta systems; the former is due, at least in part, to an increase in NO production, while the latter is due to stimulation of IL-1 beta and/or other cytokines. Paraquat 75-77 interleukin 1 beta Rattus norvegicus 127-136 12935482-9 1999 These data suggest that acute lethal poisoning and non-lethal poisoning by PQ undergo different mechanisms of action of NO and IL-1 beta systems; the former is due, at least in part, to an increase in NO production, while the latter is due to stimulation of IL-1 beta and/or other cytokines. Paraquat 75-77 interleukin 1 beta Rattus norvegicus 258-267 10439463-4 1999 Organ culture in the presence of either interleukin-1 beta or tumour necrosis factor-alpha, but not interleukin-2 or interleukin-6, further amplified the maximal contraction to sarafotoxin S6c. sarafotoxin 177-188 interleukin 1 beta Rattus norvegicus 40-90 10852035-4 1999 The study revealed that IL1 beta and the natural complex of cytokines primed peritoneal exudate cells for the production of active forms of oxygen. Oxygen 140-146 interleukin 1 beta Rattus norvegicus 24-32 10433204-6 1999 The addition of actinomycin D to IL-1beta-pretreated whole ovarian dispersates produced a pattern of (IGFBP-4 and -5) messenger RNA decay indistinguishable from that noted for the untreated control group. Dactinomycin 16-29 interleukin 1 beta Rattus norvegicus 33-41 10447558-9 1999 instillation of fluoride significantly enhanced mRNA expression of cytokines such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha, cytokine-induced neutrophil chemoattractant, and macrophage inflammatory proteins-1alpha and -2. Fluorides 16-24 interleukin 1 beta Rattus norvegicus 85-102 10447558-9 1999 instillation of fluoride significantly enhanced mRNA expression of cytokines such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha, cytokine-induced neutrophil chemoattractant, and macrophage inflammatory proteins-1alpha and -2. Fluorides 16-24 interleukin 1 beta Rattus norvegicus 104-112 10447558-10 1999 Fluoride-induced augmentation in IL-1beta mRNA expression was also examined by Northern hybridization following in vitro exposure of alveolar macrophages to fluoride. Fluorides 0-8 interleukin 1 beta Rattus norvegicus 33-41 10447558-11 1999 However, the enhancement of IL-1beta mRNA expression following in vitro exposure to fluoride was observed only at 500 microM, a dose higher than the 50% lethal concentration (LC(50)). Fluorides 84-92 interleukin 1 beta Rattus norvegicus 28-36 10482916-10 1999 Co-injection of the PKC inhibitors, staurosporine (10 nmol) or RO 318220 (30 nmol) inhibited des-Arg9-BK-induced paw oedema (44 and 42% for IL-1beta and, 53 and 30% for TNFalpha, respectively). Staurosporine 36-49 interleukin 1 beta Rattus norvegicus 140-148 10482916-10 1999 Co-injection of the PKC inhibitors, staurosporine (10 nmol) or RO 318220 (30 nmol) inhibited des-Arg9-BK-induced paw oedema (44 and 42% for IL-1beta and, 53 and 30% for TNFalpha, respectively). Ro 31-8220 63-72 interleukin 1 beta Rattus norvegicus 140-148 10482916-11 1999 Genistein (tyrosine kinase inhibitor, 2.5 mg kg-1, s.c.) or PD 098059 (MAP-kinase inhibitor, 30 nmol) produced marked inhibition of des-Arg9-BK-induced oedema (58 and 39% for IL-1beta and 31 and 35% for TNFalpha respectively). Genistein 0-9 interleukin 1 beta Rattus norvegicus 175-183 10482916-15 1999 significantly inhibited the oedema of des-Arg9-BK in IL-1beta (27 and 83%) or TNFalpha (28 and 80%) pre-treated animals. des-arg9-bk 38-49 interleukin 1 beta Rattus norvegicus 53-61 10433805-6 1999 The inhibitory action of IL-1beta (100 pM, 24 h) on rat islet insulin secretion was partially reversed by 1-h pre-treatment with glucagon (10-1000 nM), while the contrasting stimulatory effect of 48-h treatment with cytokines on insulin secretion from human islets was similarly prevented by glucagon (1000 nM) pre-treatment. Glucagon 129-137 interleukin 1 beta Rattus norvegicus 25-33 10433805-6 1999 The inhibitory action of IL-1beta (100 pM, 24 h) on rat islet insulin secretion was partially reversed by 1-h pre-treatment with glucagon (10-1000 nM), while the contrasting stimulatory effect of 48-h treatment with cytokines on insulin secretion from human islets was similarly prevented by glucagon (1000 nM) pre-treatment. Glucagon 292-300 interleukin 1 beta Rattus norvegicus 25-33 10451023-3 1999 IL-1beta was up-regulated in pineal cultures, after treatment with either norepinephrine (NE) or interferon (IFN)/lipopolysaccharide (LPS). Norepinephrine 74-88 interleukin 1 beta Rattus norvegicus 0-8 10421779-6 1999 Furthermore, the production of both IL-1beta and tumor necrosis factor (TNF)-alpha, but not that of IL-6 and IL-10, diminished in the mixed leukocyte reaction established with Dex-treated thymic DC. Dexamethasone 176-179 interleukin 1 beta Rattus norvegicus 36-44 10448891-1 1999 The effects of various antitumor agents were examined on prostacyclin production induced by interleukin-1beta in rat aortic smooth muscle cells. Epoprostenol 57-69 interleukin 1 beta Rattus norvegicus 92-109 10482376-12 1999 IL-6 did not alter NIS functional activity, but IL-1beta suppressed iodide accumulation by approximately 25%. Iodides 68-74 interleukin 1 beta Rattus norvegicus 48-56 10395742-6 1999 This effect of mannosamine appears to be due to its capacity to inhibit the synthesis of glycosylphosphatidylinositol (GPI)-linked proteins by chondrocytes since the GPI synthesis inhibitor 2-deoxyfluoroglucose (2-DFG) also inhibited the aggrecanase response to IL-1b and RA in rat cells. mannosamine 15-26 interleukin 1 beta Rattus norvegicus 262-267 10391885-6 1999 IkappaBalphaM significantly sensitized mesangial cells to TNF-alpha-induced apoptosis in a dose- and time-dependent manner but had no significant effects on the level of apoptosis in the presence of proinflammatory or apoptosis-inducing stimuli including Fas ligand, IL-1alpha, IL-1beta, hydrogen peroxide, lipopolysaccharide, cycloheximide, or serum deprivation. ikappabalpham 0-13 interleukin 1 beta Rattus norvegicus 278-286 10395742-7 1999 Moreover, phosphatidylinositol-specific phospholipase C (PIPLC) treatment of rat cells markedly inhibited the aggrecanase response to IL-1b and RA. Phosphatidylinositols 10-30 interleukin 1 beta Rattus norvegicus 134-139 10448891-2 1999 Stimulation of the cells with interleukin-1beta (2.5 ng/ml) resulted in a great increase of prostacyclin production, which was abolished by indomethacin (1 microM) or cycloheximide (2 microM). Epoprostenol 92-104 interleukin 1 beta Rattus norvegicus 30-47 10448891-2 1999 Stimulation of the cells with interleukin-1beta (2.5 ng/ml) resulted in a great increase of prostacyclin production, which was abolished by indomethacin (1 microM) or cycloheximide (2 microM). Indomethacin 140-152 interleukin 1 beta Rattus norvegicus 30-47 10448891-2 1999 Stimulation of the cells with interleukin-1beta (2.5 ng/ml) resulted in a great increase of prostacyclin production, which was abolished by indomethacin (1 microM) or cycloheximide (2 microM). Cycloheximide 167-180 interleukin 1 beta Rattus norvegicus 30-47 10448891-5 1999 Protein expression of cyclooxygenase-2 induced by interleukin-1beta was inhibited by daunorubicin at 0.1-1 microM, but was not affected by other antitumor agents. Daunorubicin 85-97 interleukin 1 beta Rattus norvegicus 50-67 10412764-0 1999 Lysophosphatidylcholine up-regulates IL-1 beta-induced iNOS expression in rat mesangial cells. Lysophosphatidylcholines 0-23 interleukin 1 beta Rattus norvegicus 37-46 10409173-8 1999 Bacterial cell wall polymers directly stimulated collagen alpha1 (I), TGF-beta1, IL-1beta, and IL-6 mRNA expression in the intestinal myofibroblasts derived from both normal and inflamed cecum. Polymers 20-28 interleukin 1 beta Rattus norvegicus 81-89 10444313-7 1999 injection of rat recombinant IL-1beta (rrIL-1beta), 0.5 microg/kg in 0.9% sterile saline/0.01% rat serum albumin. Sodium Chloride 82-88 interleukin 1 beta Rattus norvegicus 29-37 10412764-6 1999 METHODS AND RESULTS: Treatment of mesangial cells with interleukin-1 beta (IL-1 beta) induced iNOS activity measured as nitrite levels in cell culture supernatants. Nitrites 120-127 interleukin 1 beta Rattus norvegicus 55-73 10412764-6 1999 METHODS AND RESULTS: Treatment of mesangial cells with interleukin-1 beta (IL-1 beta) induced iNOS activity measured as nitrite levels in cell culture supernatants. Nitrites 120-127 interleukin 1 beta Rattus norvegicus 75-84 10412764-8 1999 In contrast, coincubation with LPC and IL-1 beta resulted in a markedly higher nitrite content compared to that after incubation with IL-1 beta alone. Nitrites 79-86 interleukin 1 beta Rattus norvegicus 39-48 10412764-8 1999 In contrast, coincubation with LPC and IL-1 beta resulted in a markedly higher nitrite content compared to that after incubation with IL-1 beta alone. Nitrites 79-86 interleukin 1 beta Rattus norvegicus 134-143 11798681-0 1999 [The role of nitric oxide on the functional change of interleukin-1 beta and interleukin-6 induced rat pancreatic islets of Langerhans]. Nitric Oxide 13-25 interleukin 1 beta Rattus norvegicus 54-72 10463335-0 1999 Interleukin-1beta-induced nitric oxide synthesis in aortic rings from normal and hyperinsulinaemic rats: effect of physical exercise. Nitric Oxide 26-38 interleukin 1 beta Rattus norvegicus 0-17 10463335-5 1999 A 6-h incubation of aortic rings with IL-1beta (10 ng/ml) increased cyclic GMP in smooth muscle by approximately threefold in all groups, and this effect was prevented by methylene blue. Cyclic GMP 68-78 interleukin 1 beta Rattus norvegicus 38-46 10463335-5 1999 A 6-h incubation of aortic rings with IL-1beta (10 ng/ml) increased cyclic GMP in smooth muscle by approximately threefold in all groups, and this effect was prevented by methylene blue. Methylene Blue 171-185 interleukin 1 beta Rattus norvegicus 38-46 10463335-6 1999 The contractile sensitivity of endothelium-denuded aortic rings to phenylephrine was reduced by incubation with IL-1beta (1 ng/ml and 10 ng/ml) in the exercised obese and lean rats, whereas no significant change was observed in the sedentary groups. Phenylephrine 67-80 interleukin 1 beta Rattus norvegicus 112-120 10463335-7 1999 The aortic maximal contractile force induced by phenylephrine was reduced in sedentary and exercised obese rats by incubation with IL-1beta, while no change was detected in the lean rats. Phenylephrine 48-61 interleukin 1 beta Rattus norvegicus 131-139 10463335-8 1999 The aortic relaxation to exogenous L-arginine was augmented by IL-1beta in all groups, while the relaxation sensitivity to L-arginine after induction by IL-1beta was enhanced by exercise in the obese but not in the lean rats. Arginine 123-133 interleukin 1 beta Rattus norvegicus 153-161 10463335-10 1999 In conclusion, since maximal contractile force generation to phenylephrine was reduced by IL-1beta in the obese but not in the lean rats, the sensitivity of NOS to induction by IL-1beta was higher in arterial smooth muscle of the obese than the lean Zucker rats. Phenylephrine 61-74 interleukin 1 beta Rattus norvegicus 90-98 11798681-1 1999 OBJECTIVE: To observe the effects of interleukin (IL)-1 beta and IL-6 on nitric oxide (NO) production, islet cell DNA and insulin content, and MTT assay of rat pancreatic islets of Langerhans. Nitric Oxide 73-85 interleukin 1 beta Rattus norvegicus 37-60 11798681-5 1999 RESULTS: IL-1 beta induced a significant increase in nitrite production, a decrease of islet cell DNA and insulin content and reduction of cell activity (MTT, P < 0.001); these changes were blocked by L-NMMA (P < 0.001). Nitrites 53-60 interleukin 1 beta Rattus norvegicus 9-18 10366638-0 1999 Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures. Kainic Acid 94-101 interleukin 1 beta Rattus norvegicus 0-17 11798681-5 1999 RESULTS: IL-1 beta induced a significant increase in nitrite production, a decrease of islet cell DNA and insulin content and reduction of cell activity (MTT, P < 0.001); these changes were blocked by L-NMMA (P < 0.001). monooxyethylene trimethylolpropane tristearate 154-157 interleukin 1 beta Rattus norvegicus 9-18 11798681-5 1999 RESULTS: IL-1 beta induced a significant increase in nitrite production, a decrease of islet cell DNA and insulin content and reduction of cell activity (MTT, P < 0.001); these changes were blocked by L-NMMA (P < 0.001). omega-N-Methylarginine 204-210 interleukin 1 beta Rattus norvegicus 9-18 10422760-0 1999 Interleukin-1beta inhibits a tetraethylammonium-induced synaptic potentiation in the rat dentate gyrus in vitro. Tetraethylammonium 29-47 interleukin 1 beta Rattus norvegicus 0-17 10422760-1 1999 The effect of the pro-inflammatory cytokine, interleukin-1beta on an NMDA receptor-independent form of synaptic plasticity brought about by the application of the K+ channel blocker tetraethylammonium, was examined in the rat dentate gyrus in vitro. Tetraethylammonium 182-200 interleukin 1 beta Rattus norvegicus 45-62 10422760-6 1999 The inhibitory effect of interleukin-1beta on both tetraethylammonium induced long-term potentiation and the tetraethylammonium induced increase in paired pulse depression was antagonised by pre-incubation with the interleukin-1 receptor antagonist. Tetraethylammonium 51-69 interleukin 1 beta Rattus norvegicus 25-42 10422760-6 1999 The inhibitory effect of interleukin-1beta on both tetraethylammonium induced long-term potentiation and the tetraethylammonium induced increase in paired pulse depression was antagonised by pre-incubation with the interleukin-1 receptor antagonist. Tetraethylammonium 109-127 interleukin 1 beta Rattus norvegicus 25-42 10366638-1 1999 Using immunocytochemistry and ELISA, we investigated the production of interleukin (IL)-1beta in the rat hippocampus after focal application of kainic acid inducing electroencephalographic (EEG) seizures and CA3 neuronal cell loss. Kainic Acid 144-155 interleukin 1 beta Rattus norvegicus 71-93 10366638-4 1999 Three and 24 hr after unilateral intrahippocampal application of 0.19 nmol of kainate, IL-1beta immunoreactivity was enhanced in glia in the injected and the contralateral hippocampi. Kainic Acid 78-85 interleukin 1 beta Rattus norvegicus 87-95 10366638-7 1999 Intrahippocampal application of 0.77 nmol of bicuculline methiodide, which induces EEG seizures but not cell loss, enhanced IL-1beta immunoreactivity and microglia, although to a less extent and for a shorter time compared with kainate. bicuculline methiodide 45-67 interleukin 1 beta Rattus norvegicus 124-132 10366638-8 1999 One nanogram of (hr)IL-1beta intrahippocampally injected 10 min before kainate enhanced by 226% the time spent in seizures (p < 0.01). Kainic Acid 71-78 interleukin 1 beta Rattus norvegicus 20-28 10366638-9 1999 This effect was blocked by coinjection of 1 microgram (hr)IL-1beta receptor antagonist or 0.1 ng of 3-((+)-2-carboxypiperazin-4-yl)-propyl-1-phosphonate, selective antagonists of IL-1beta and NMDA receptors, respectively. 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid 100-152 interleukin 1 beta Rattus norvegicus 179-187 10366638-11 1999 In addition, exogenous application of IL-1beta prolongs kainate-induced hippocampal EEG seizures by enhancing glutamatergic neurotransmission. Kainic Acid 56-63 interleukin 1 beta Rattus norvegicus 38-46 10433392-7 1999 This greater ability from the older rGF cells to produce PGE2 and IL-1beta was due to higher mRNA levels of cyclooxygenase 2 and IL-1beta, respectively. Dinoprostone 57-61 interleukin 1 beta Rattus norvegicus 129-137 10414441-0 1999 Granulocyte-macrophage colony-stimulating factor enhances interleukin-1beta stimulated histamine release in the preovulatory rat ovary. Histamine 87-96 interleukin 1 beta Rattus norvegicus 58-75 10414441-2 1999 The aim of the present study was to investigate whether granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-1beta are capable of stimulating histamine release and steroidogenesis in rat ovary, and to determine the sites of histamine production in the ovary. Histamine 163-172 interleukin 1 beta Rattus norvegicus 118-135 10414441-2 1999 The aim of the present study was to investigate whether granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-1beta are capable of stimulating histamine release and steroidogenesis in rat ovary, and to determine the sites of histamine production in the ovary. Histamine 245-254 interleukin 1 beta Rattus norvegicus 118-135 10414441-3 1999 Histamine release from preovulatory ovarian tissues was stimulated in a dose-dependent manner at 3-30 ng/ml of GM-CSF in the presence of interleukin-1beta (10 ng/ml). Histamine 0-9 interleukin 1 beta Rattus norvegicus 137-154 10414441-6 1999 These results indicate that GM-CSF may be involved in the regulation of ovarian histamine secretion in mast cells partially by enhancing interleukin-1beta-induced histamine release in the process of ovulation. Histamine 80-89 interleukin 1 beta Rattus norvegicus 137-154 10414441-6 1999 These results indicate that GM-CSF may be involved in the regulation of ovarian histamine secretion in mast cells partially by enhancing interleukin-1beta-induced histamine release in the process of ovulation. Histamine 163-172 interleukin 1 beta Rattus norvegicus 137-154 10346979-0 1999 Interleukin 1beta increases arginine accumulation and activates the citrulline-NO cycle in rat pancreatic beta cells. Arginine 28-36 interleukin 1 beta Rattus norvegicus 0-17 10346979-0 1999 Interleukin 1beta increases arginine accumulation and activates the citrulline-NO cycle in rat pancreatic beta cells. Citrulline 68-78 interleukin 1 beta Rattus norvegicus 0-17 10346979-6 1999 This study demonstrates for the first time that the citrulline-NO cycle is induced in FACS-purified rat beta cells exposed to interleukin-1beta(IL-1beta) and that extracellular arginine or citrulline is required for NO production by beta cells. Citrulline 52-62 interleukin 1 beta Rattus norvegicus 126-143 10346979-6 1999 This study demonstrates for the first time that the citrulline-NO cycle is induced in FACS-purified rat beta cells exposed to interleukin-1beta(IL-1beta) and that extracellular arginine or citrulline is required for NO production by beta cells. Citrulline 52-62 interleukin 1 beta Rattus norvegicus 144-152 10346979-7 1999 Moreover, the accumulation of arginine was higher in IL-1beta-treated beta cells than in control cells.beta cells expressed mRNAs for the two y+CAT transporters CAT-2A and CAT-2B with no change in transporter expression after exposure to IL-1beta. Arginine 30-38 interleukin 1 beta Rattus norvegicus 53-61 10433392-9 1999 Because LPS-stimulated PGE2 and IL-1beta production was enhanced by in vivo cellular aging, aging of GF may affect the severity of inflammation and bone resorption by producing a large amount of PGE2 and IL-1beta in response to bacterial infection. Dinoprostone 195-199 interleukin 1 beta Rattus norvegicus 32-40 10433360-0 1999 Role of interleukin-1beta in the modulations of cytochrome P450 and heme metabolism in rat liver. Heme 68-72 interleukin 1 beta Rattus norvegicus 8-25 10401621-4 1999 Interleukin-1 beta/cAMP activated mesangial cells released NO and in turn showed PDGFR phosphorylation. Cyclic AMP 19-23 interleukin 1 beta Rattus norvegicus 0-18 10433360-2 1999 To assess the effect of IL-1beta on heme metabolism, we determined the delta-aminolevulinic acid synthetase (delta-ALAS) and heme oxygenase activities in the liver. Heme 36-40 interleukin 1 beta Rattus norvegicus 24-32 10433360-3 1999 IL-1beta suppressed the microsomal total P450 and heme contents and delta-ALAS activity in the liver. Heme 50-54 interleukin 1 beta Rattus norvegicus 0-8 10433360-6 1999 IL-1beta inhibited both allylisopropylamide- and phenobarbital-inducible delta-ALAS activities in the liver. allylisopropylamide 24-43 interleukin 1 beta Rattus norvegicus 0-8 10406194-8 1999 FK506 markedly inhibited the nitric oxide formation, inducible nitric oxide synthase protein synthesis and inducible nitric oxide synthase mRNA expression induced by interleukin 1beta, but cyclosporin A had no effects. Tacrolimus 0-5 interleukin 1 beta Rattus norvegicus 166-183 10406194-8 1999 FK506 markedly inhibited the nitric oxide formation, inducible nitric oxide synthase protein synthesis and inducible nitric oxide synthase mRNA expression induced by interleukin 1beta, but cyclosporin A had no effects. Nitric Oxide 29-41 interleukin 1 beta Rattus norvegicus 166-183 10406194-3 1999 Studies were performed to determine whether the immunosuppressants FK506 and cyclosporin A directly influence gene expression of inducible nitric oxide synthase by interleukin 1beta in hepatocytes. Tacrolimus 67-72 interleukin 1 beta Rattus norvegicus 164-181 10406194-3 1999 Studies were performed to determine whether the immunosuppressants FK506 and cyclosporin A directly influence gene expression of inducible nitric oxide synthase by interleukin 1beta in hepatocytes. Cyclosporine 77-90 interleukin 1 beta Rattus norvegicus 164-181 10406194-6 1999 RESULTS: Interleukin 1beta increased levels of inducible nitric oxide synthase protein and inducible nitric oxide synthase mRNA, as well as nitric oxide production, in the cultured hepatocytes. Nitric Oxide 57-69 interleukin 1 beta Rattus norvegicus 9-26 10433360-6 1999 IL-1beta inhibited both allylisopropylamide- and phenobarbital-inducible delta-ALAS activities in the liver. Phenobarbital 49-62 interleukin 1 beta Rattus norvegicus 0-8 10433360-8 1999 Thus, the modulation of hepatic P450 by IL-1beta is complex, and IL-1beta may be involved in the regulation of both apoprotein synthesis for each P450 isoform and the heme pools in the liver. Heme 167-171 interleukin 1 beta Rattus norvegicus 65-73 10433366-3 1999 Increases in calcium also occurred with interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), but not to the extent seen with IFN-gamma. Calcium 13-20 interleukin 1 beta Rattus norvegicus 40-57 10341228-0 1999 Adenosine: a mediator of interleukin-1beta-induced hippocampal synaptic inhibition. Adenosine 0-9 interleukin 1 beta Rattus norvegicus 25-42 10341228-4 1999 We report here that, in rat brain slices, brief application of sub-femtomolar IL-1beta causes a profound decrease of glutamate transmission, but not GABAergic inhibition, in hippocampal CA1 pyramidal neurons. Glutamic Acid 117-126 interleukin 1 beta Rattus norvegicus 78-86 10341228-7 1999 Because the production and release of adenosine in the CNS is thought to be metabolically dependent, this observation suggests that one of the functions of IL-1beta is to increase the endogenous production of adenosine. Adenosine 38-47 interleukin 1 beta Rattus norvegicus 156-164 10341228-7 1999 Because the production and release of adenosine in the CNS is thought to be metabolically dependent, this observation suggests that one of the functions of IL-1beta is to increase the endogenous production of adenosine. Adenosine 209-218 interleukin 1 beta Rattus norvegicus 156-164 10433366-3 1999 Increases in calcium also occurred with interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), but not to the extent seen with IFN-gamma. Calcium 13-20 interleukin 1 beta Rattus norvegicus 59-67 10382232-2 1999 Because effects of inflammatory cytokines on the proliferation of alveolar type II cells are not clear, we investigated the effects of interleukin-1 beta (IL-1 beta) on [3H]-thymidine incorporation into DNA in rat alveolar type II cells in primary culture. Tritium 170-172 interleukin 1 beta Rattus norvegicus 135-153 10382232-2 1999 Because effects of inflammatory cytokines on the proliferation of alveolar type II cells are not clear, we investigated the effects of interleukin-1 beta (IL-1 beta) on [3H]-thymidine incorporation into DNA in rat alveolar type II cells in primary culture. Tritium 170-172 interleukin 1 beta Rattus norvegicus 155-164 10382232-2 1999 Because effects of inflammatory cytokines on the proliferation of alveolar type II cells are not clear, we investigated the effects of interleukin-1 beta (IL-1 beta) on [3H]-thymidine incorporation into DNA in rat alveolar type II cells in primary culture. Thymidine 174-183 interleukin 1 beta Rattus norvegicus 135-153 10382232-2 1999 Because effects of inflammatory cytokines on the proliferation of alveolar type II cells are not clear, we investigated the effects of interleukin-1 beta (IL-1 beta) on [3H]-thymidine incorporation into DNA in rat alveolar type II cells in primary culture. Thymidine 174-183 interleukin 1 beta Rattus norvegicus 155-164 10329110-8 1999 KC reduction by prior administration of gadolinium chloride, however, prevented the occurrence of hepatocellular dysfunction and the upregulation of IL-1beta and IL-6. gadolinium chloride 40-59 interleukin 1 beta Rattus norvegicus 149-157 10382232-3 1999 Interleukin-1 beta enhanced the [3H]-thymidine incorporation dose and time dependently. Tritium 33-35 interleukin 1 beta Rattus norvegicus 0-18 10382232-3 1999 Interleukin-1 beta enhanced the [3H]-thymidine incorporation dose and time dependently. Thymidine 37-46 interleukin 1 beta Rattus norvegicus 0-18 10382232-5 1999 The effect of IL-1 beta on [3H]-thymidine incorporation was additive to effects of growth factors which were known to act as mitogenic factors for type II cells. Tritium 28-30 interleukin 1 beta Rattus norvegicus 14-23 10382232-5 1999 The effect of IL-1 beta on [3H]-thymidine incorporation was additive to effects of growth factors which were known to act as mitogenic factors for type II cells. Thymidine 32-41 interleukin 1 beta Rattus norvegicus 14-23 10382232-6 1999 Anti-interleukin-1 beta antibody or IL-1 receptor antagonist partially inhibited the effects of IL-1 beta on [3H]-thymidine incorporation. Tritium 110-112 interleukin 1 beta Rattus norvegicus 5-23 10382232-6 1999 Anti-interleukin-1 beta antibody or IL-1 receptor antagonist partially inhibited the effects of IL-1 beta on [3H]-thymidine incorporation. Tritium 110-112 interleukin 1 beta Rattus norvegicus 96-105 10382232-6 1999 Anti-interleukin-1 beta antibody or IL-1 receptor antagonist partially inhibited the effects of IL-1 beta on [3H]-thymidine incorporation. Thymidine 114-123 interleukin 1 beta Rattus norvegicus 5-23 10382232-6 1999 Anti-interleukin-1 beta antibody or IL-1 receptor antagonist partially inhibited the effects of IL-1 beta on [3H]-thymidine incorporation. Thymidine 114-123 interleukin 1 beta Rattus norvegicus 96-105 10328229-8 1999 The content of IFN-gamma and IL-1beta in tumors was enhanced during lipid A treatment; this is in agreement with an indirect effect of lipid A in vivo via the IFN-gamma and IL-1beta pathways. Lipid A 68-75 interleukin 1 beta Rattus norvegicus 29-37 10328229-8 1999 The content of IFN-gamma and IL-1beta in tumors was enhanced during lipid A treatment; this is in agreement with an indirect effect of lipid A in vivo via the IFN-gamma and IL-1beta pathways. Lipid A 68-75 interleukin 1 beta Rattus norvegicus 173-181 10328229-8 1999 The content of IFN-gamma and IL-1beta in tumors was enhanced during lipid A treatment; this is in agreement with an indirect effect of lipid A in vivo via the IFN-gamma and IL-1beta pathways. Lipid A 135-142 interleukin 1 beta Rattus norvegicus 29-37 10328229-8 1999 The content of IFN-gamma and IL-1beta in tumors was enhanced during lipid A treatment; this is in agreement with an indirect effect of lipid A in vivo via the IFN-gamma and IL-1beta pathways. Lipid A 135-142 interleukin 1 beta Rattus norvegicus 173-181 10350552-8 1999 Spinal sections from both formalin and zymosan treated animals exhibited microglial and astrocytic activation and increased Interleukin-1beta immunoreactivity at 1 and 6 h, respectively. Formaldehyde 26-34 interleukin 1 beta Rattus norvegicus 124-141 10350552-8 1999 Spinal sections from both formalin and zymosan treated animals exhibited microglial and astrocytic activation and increased Interleukin-1beta immunoreactivity at 1 and 6 h, respectively. Zymosan 39-46 interleukin 1 beta Rattus norvegicus 124-141 10350552-9 1999 Spinal glial activation and upregulation of Interleukin-1beta appear to parallel the development and maintenance of zymosan and formalin-induced mechanical allodynia. Zymosan 116-123 interleukin 1 beta Rattus norvegicus 44-61 10350552-9 1999 Spinal glial activation and upregulation of Interleukin-1beta appear to parallel the development and maintenance of zymosan and formalin-induced mechanical allodynia. Formaldehyde 128-136 interleukin 1 beta Rattus norvegicus 44-61 10233181-9 1999 At the 80th hour, submucosal macrophages were positive for TNFalpha and colonic production of IL1beta and interferon gamma was increased; all these effects were reduced by octreotide treatment. Octreotide 172-182 interleukin 1 beta Rattus norvegicus 94-101 10400310-3 1999 Carbon tetrachloride treatment increased IL-1beta and decreased TNF-alpha and IL-6. Carbon Tetrachloride 0-20 interleukin 1 beta Rattus norvegicus 41-49 10218970-4 1999 Both interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha potently stimulated nitrite/nitrate (NOx) production with a concomitant expression of iNOS mRNA and protein as demonstrated by Northern and Western blot analysis, respectively. Nitrites 86-94 interleukin 1 beta Rattus norvegicus 5-27 10369455-2 1999 Interleukin 1beta (IL-1beta) induces both enzymes with a similar time course resulting in an increase in nitrite production and sPLA2-IIA activity. Nitrites 105-112 interleukin 1 beta Rattus norvegicus 0-17 10369455-2 1999 Interleukin 1beta (IL-1beta) induces both enzymes with a similar time course resulting in an increase in nitrite production and sPLA2-IIA activity. Nitrites 105-112 interleukin 1 beta Rattus norvegicus 19-27 10369455-6 1999 Coincubation of cells with IL-1beta and the NOS inhibitor, L-N(G) monomethylarginine (L-NMMA), caused a dose-dependent inhibition of cytokine-induced sPLA2-IIA mRNA expression and activity. l-n(g) monomethylarginine 59-84 interleukin 1 beta Rattus norvegicus 27-35 10369455-6 1999 Coincubation of cells with IL-1beta and the NOS inhibitor, L-N(G) monomethylarginine (L-NMMA), caused a dose-dependent inhibition of cytokine-induced sPLA2-IIA mRNA expression and activity. N(G)-monomethylarginine acetate 86-92 interleukin 1 beta Rattus norvegicus 27-35 10228105-7 1999 Inhalation of peptidase inhibitors (phosphoramidon plus captopril) potentiated the effect of both hIL-17 and rIL-1beta. phosphoramidon 36-50 interleukin 1 beta Rattus norvegicus 109-118 10228105-7 1999 Inhalation of peptidase inhibitors (phosphoramidon plus captopril) potentiated the effect of both hIL-17 and rIL-1beta. Captopril 56-65 interleukin 1 beta Rattus norvegicus 109-118 10218970-4 1999 Both interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha potently stimulated nitrite/nitrate (NOx) production with a concomitant expression of iNOS mRNA and protein as demonstrated by Northern and Western blot analysis, respectively. Nitrates 94-101 interleukin 1 beta Rattus norvegicus 5-27 10218970-4 1999 Both interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha potently stimulated nitrite/nitrate (NOx) production with a concomitant expression of iNOS mRNA and protein as demonstrated by Northern and Western blot analysis, respectively. nicotine 1-N-oxide 103-106 interleukin 1 beta Rattus norvegicus 5-27 10202258-7 1999 RESULTS: We report that interleukin-1beta increased lipid peroxidation in hippocampal tissue prepared from 4- but not 22-month-old rats, and that this effect was inhibited by alpha-tocopherol. alpha-Tocopherol 175-191 interleukin 1 beta Rattus norvegicus 24-41 10202258-9 1999 Thus, using an ELISA, we have demonstrated an age-related increase in the concentration of interleukin-1beta, which is accompanied by an age-related decrease in membrane arachidonic acid. Arachidonic Acid 170-186 interleukin 1 beta Rattus norvegicus 91-108 10650342-2 1999 We hypothesized that systemic administration of IL-1beta would increase ventilation (V(E )), and that nitric oxide, eicosanoids, and glucocorticoid receptors would modulate IL-1beta-induced cardioventilatory responses. Nitric Oxide 102-114 interleukin 1 beta Rattus norvegicus 173-181 10365824-8 1999 RESULTS: IL-1beta augmented the induction of nitric oxide production two-fold in hepatocytes from the PH rats as compared to the control rats. Nitric Oxide 45-57 interleukin 1 beta Rattus norvegicus 9-17 10365824-9 1999 IL-1beta markedly decreased the ATP content in the PH rats, although IL-1beta also decreased the ATP content in the control rats, but to a lesser extent. Adenosine Triphosphate 32-35 interleukin 1 beta Rattus norvegicus 0-8 10365824-9 1999 IL-1beta markedly decreased the ATP content in the PH rats, although IL-1beta also decreased the ATP content in the control rats, but to a lesser extent. Adenosine Triphosphate 97-100 interleukin 1 beta Rattus norvegicus 69-77 10365824-10 1999 IL-1beta also decreased the ketone body ratio in both groups. Ketones 28-34 interleukin 1 beta Rattus norvegicus 0-8 10365824-12 1999 N(G)-monomethyl-L-arginine, an inhibitor of nitric oxide synthase, abolished the effects of IL-1beta on the ATP levels and ketone body ratio, as well as on the nitric oxide production. omega-N-Methylarginine 0-26 interleukin 1 beta Rattus norvegicus 92-100 10365824-12 1999 N(G)-monomethyl-L-arginine, an inhibitor of nitric oxide synthase, abolished the effects of IL-1beta on the ATP levels and ketone body ratio, as well as on the nitric oxide production. nitric 44-50 interleukin 1 beta Rattus norvegicus 92-100 10365824-12 1999 N(G)-monomethyl-L-arginine, an inhibitor of nitric oxide synthase, abolished the effects of IL-1beta on the ATP levels and ketone body ratio, as well as on the nitric oxide production. Adenosine Triphosphate 108-111 interleukin 1 beta Rattus norvegicus 92-100 10365824-12 1999 N(G)-monomethyl-L-arginine, an inhibitor of nitric oxide synthase, abolished the effects of IL-1beta on the ATP levels and ketone body ratio, as well as on the nitric oxide production. Ketones 123-129 interleukin 1 beta Rattus norvegicus 92-100 10365824-12 1999 N(G)-monomethyl-L-arginine, an inhibitor of nitric oxide synthase, abolished the effects of IL-1beta on the ATP levels and ketone body ratio, as well as on the nitric oxide production. Nitric Oxide 44-56 interleukin 1 beta Rattus norvegicus 92-100 10353541-7 1999 Both turpentine injection and CLP increased expression of TNFalpha/IL-1beta-regulated alpha1-acid glycoprotein, and IL-6-regulated alpha2-macroglobulin and decreased expression of transthyretin (a negative acute phase protein). Turpentine 5-15 interleukin 1 beta Rattus norvegicus 67-75 10353541-9 1999 Turpentine injection increased the activity of the TNFalpha/IL-1beta-linked transcription factor NF-kappaB and the intrahepatic abundance of TNFalpha in a manner similar to that observed after CLP but only slightly altered the activity of the IL-6-linked transcription factor Stat-3 and intrahepatic IL-6 abundance. Turpentine 0-10 interleukin 1 beta Rattus norvegicus 60-68 10196453-8 1999 It is concluded that LPS produces highly specific changes in monamine metabolism in the hypothalamus and that these effects are mediated at least in part by IL-1beta. Meclizine 61-69 interleukin 1 beta Rattus norvegicus 157-165 10084970-0 1999 Glucocorticoid receptor-mediated post-ceramide inhibition of the interleukin-1beta-dependent induction of ovarian prostaglandin endoperoxide synthase-2 in rats. Ceramides 38-46 interleukin 1 beta Rattus norvegicus 65-82 10084970-7 1999 The dexamethasone effect was not limited to the IL-1-mediated induction of PGS-2 transcripts, comparable suppression being noted for the IL-1-mediated up-regulation of ovarian transcripts corresponding to IL-1beta, the IL-1 receptor antagonist, and the type I IL-1 receptor. Dexamethasone 4-17 interleukin 1 beta Rattus norvegicus 205-213 10650342-2 1999 We hypothesized that systemic administration of IL-1beta would increase ventilation (V(E )), and that nitric oxide, eicosanoids, and glucocorticoid receptors would modulate IL-1beta-induced cardioventilatory responses. Eicosanoids 116-127 interleukin 1 beta Rattus norvegicus 173-181 10650342-10 1999 In addition, nitric oxide and eicosanoid-dependent mechanisms modulate IL-1beta ventilatory effects. Nitric Oxide 13-25 interleukin 1 beta Rattus norvegicus 71-79 10650342-10 1999 In addition, nitric oxide and eicosanoid-dependent mechanisms modulate IL-1beta ventilatory effects. Eicosanoids 30-40 interleukin 1 beta Rattus norvegicus 71-79 10342285-8 1999 After a treatment with interleukin-1 beta for 24 hr, contractile effects of phenylephrine (1 microM-10 microM) were markedly inhibited in the presence of L-NMMA (100 microM) applied to inhibit NO synthesis. Phenylephrine 76-89 interleukin 1 beta Rattus norvegicus 23-41 10086983-3 1999 In such rats, IL-1beta (10 microgram/kg) induced a biphasic pressor response, with a rise in the plasma concentration of NOx (NO2(-) and NO3(-): metabolites of NO) during the second phase. nicotine 1-N-oxide 121-124 interleukin 1 beta Rattus norvegicus 14-22 10086983-3 1999 In such rats, IL-1beta (10 microgram/kg) induced a biphasic pressor response, with a rise in the plasma concentration of NOx (NO2(-) and NO3(-): metabolites of NO) during the second phase. Nitrogen Dioxide 126-129 interleukin 1 beta Rattus norvegicus 14-22 10086983-3 1999 In such rats, IL-1beta (10 microgram/kg) induced a biphasic pressor response, with a rise in the plasma concentration of NOx (NO2(-) and NO3(-): metabolites of NO) during the second phase. punky blue 137-140 interleukin 1 beta Rattus norvegicus 14-22 10086983-6 1999 After bilateral adrenalectomy, IL-1beta induced a smaller pressor response, but a larger increase in plasma NOx; dexamethasone reversed these changes. nicotine 1-N-oxide 108-111 interleukin 1 beta Rattus norvegicus 31-39 10090833-2 1999 We wanted to study how cGMP and cAMP interact to affect the induced synthesis of NO in response to interleukin-1 beta (IL-1 beta) in rat pulmonary artery smooth muscle cells. Cyclic GMP 23-27 interleukin 1 beta Rattus norvegicus 99-117 10090833-2 1999 We wanted to study how cGMP and cAMP interact to affect the induced synthesis of NO in response to interleukin-1 beta (IL-1 beta) in rat pulmonary artery smooth muscle cells. Cyclic GMP 23-27 interleukin 1 beta Rattus norvegicus 119-128 10090833-2 1999 We wanted to study how cGMP and cAMP interact to affect the induced synthesis of NO in response to interleukin-1 beta (IL-1 beta) in rat pulmonary artery smooth muscle cells. Cyclic AMP 32-36 interleukin 1 beta Rattus norvegicus 99-117 10090833-2 1999 We wanted to study how cGMP and cAMP interact to affect the induced synthesis of NO in response to interleukin-1 beta (IL-1 beta) in rat pulmonary artery smooth muscle cells. Cyclic AMP 32-36 interleukin 1 beta Rattus norvegicus 119-128 10090833-7 1999 RESULTS: IL-1 beta caused nitrite levels to increase nearly 10-fold over basal levels at 24 h (P < 0.05). Nitrites 26-33 interleukin 1 beta Rattus norvegicus 9-18 10090833-8 1999 Nitrite levels increased with the addition of either db-cAMP (100 microM, an 8-fold increase) or 8-Br-cGMP (100 microM, a 3-fold increase) to IL-1 beta (P < 0.05). Nitrites 0-7 interleukin 1 beta Rattus norvegicus 142-151 10090833-8 1999 Nitrite levels increased with the addition of either db-cAMP (100 microM, an 8-fold increase) or 8-Br-cGMP (100 microM, a 3-fold increase) to IL-1 beta (P < 0.05). Bucladesine 53-60 interleukin 1 beta Rattus norvegicus 142-151 10090833-8 1999 Nitrite levels increased with the addition of either db-cAMP (100 microM, an 8-fold increase) or 8-Br-cGMP (100 microM, a 3-fold increase) to IL-1 beta (P < 0.05). 8-bromocyclic GMP 97-106 interleukin 1 beta Rattus norvegicus 142-151 10090833-9 1999 PKA inhibition with KT5720 (10(-5) M) completely inhibited NO synthesis in response to the combination of IL-1 beta and cAMP, while KT5823 had less effect at all doses tested. KT 5720 20-26 interleukin 1 beta Rattus norvegicus 106-115 10090833-10 1999 NO synthesis in response to IL-1 beta plus cGMP also decreased to PKA inhibition, but not PKG inhibition, indicating that cGMP responses are a crossover effect. Cyclic GMP 122-126 interleukin 1 beta Rattus norvegicus 28-37 10086983-6 1999 After bilateral adrenalectomy, IL-1beta induced a smaller pressor response, but a larger increase in plasma NOx; dexamethasone reversed these changes. Dexamethasone 113-126 interleukin 1 beta Rattus norvegicus 31-39 10342285-8 1999 After a treatment with interleukin-1 beta for 24 hr, contractile effects of phenylephrine (1 microM-10 microM) were markedly inhibited in the presence of L-NMMA (100 microM) applied to inhibit NO synthesis. omega-N-Methylarginine 154-160 interleukin 1 beta Rattus norvegicus 23-41 10342285-9 1999 A blocker of ATP-sensitive K+ channel, glibenclamide (1 microM), partially recovered the interleukin-1 beta-induced inhibition. Glyburide 39-52 interleukin 1 beta Rattus norvegicus 89-107 10220113-2 1999 In the present study, we show that interleukin 1beta (IL1beta), H2O2, and sorbitol-induced hyperosmolarity mediate a 5- to 10-fold increase in phosphorylation (activation) of the p38 protein kinase in rat primary glial cells as measured by analyses of Western blots using an antibody directed against the dually phosphorylated (active) p38. Sorbitol 74-82 interleukin 1 beta Rattus norvegicus 35-52 10200991-0 1999 Angiotensin II inhibits interleukin-1 beta-induced nitric oxide production in cultured rat mesangial cells. Nitric Oxide 51-63 interleukin 1 beta Rattus norvegicus 24-42 10200991-7 1999 RESULTS: Angiotensin II and TGF-beta significantly decreased IL-1 beta-stimulated nitrite accumulation. Nitrites 82-89 interleukin 1 beta Rattus norvegicus 61-70 10220113-3 1999 Additionally, IL1beta was found to elicit H2O2 synthesis in these cells. Hydrogen Peroxide 42-46 interleukin 1 beta Rattus norvegicus 14-21 10220113-6 1999 Pretreatment of cells with either PBN or NAC at 1.0 mM suppressed IL1beta H2O2, and sorbitol-mediated activation of p38 and significantly increased phosphatase activity. phenyl-N-tert-butylnitrone 34-37 interleukin 1 beta Rattus norvegicus 66-73 10220113-6 1999 Pretreatment of cells with either PBN or NAC at 1.0 mM suppressed IL1beta H2O2, and sorbitol-mediated activation of p38 and significantly increased phosphatase activity. Acetylcysteine 41-44 interleukin 1 beta Rattus norvegicus 66-73 10220113-6 1999 Pretreatment of cells with either PBN or NAC at 1.0 mM suppressed IL1beta H2O2, and sorbitol-mediated activation of p38 and significantly increased phosphatase activity. Hydrogen Peroxide 74-78 interleukin 1 beta Rattus norvegicus 66-73 10069792-5 1999 The IL-1beta-induced nitrite production by VSMCs was significantly increased by homocysteine in a dose-dependent manner. Nitrites 21-28 interleukin 1 beta Rattus norvegicus 4-12 10066820-5 1999 However, a combination of wortmannin or LY294002 with LPS or IL-1beta induced the expression of iNOS and the production of NO in C6 glial cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 40-48 interleukin 1 beta Rattus norvegicus 61-69 10066820-6 1999 Consistent with the induction of iNOS, wortmannin also induced iNOS promoter-derived chloramphenicol acetyltransferase activity in LPS- or IL-1beta-treated C6 glial cells. Wortmannin 39-49 interleukin 1 beta Rattus norvegicus 139-147 10066820-8 1999 Next we examined the effect of wortmannin on the activation of mitogen-activated protein (MAP) kinase and nuclear factor NF-kappaB in LPS- or IL-1beta-stimulated C6 glial cells. Wortmannin 31-41 interleukin 1 beta Rattus norvegicus 142-150 10069792-5 1999 The IL-1beta-induced nitrite production by VSMCs was significantly increased by homocysteine in a dose-dependent manner. Homocysteine 80-92 interleukin 1 beta Rattus norvegicus 4-12 10069792-8 1999 Cysteine, glutathione, or hydrogen peroxide also increased nitrite accumulation in IL-1beta-stimulated VSMCs. Cysteine 0-8 interleukin 1 beta Rattus norvegicus 83-91 10069792-8 1999 Cysteine, glutathione, or hydrogen peroxide also increased nitrite accumulation in IL-1beta-stimulated VSMCs. Glutathione 10-21 interleukin 1 beta Rattus norvegicus 83-91 10069792-8 1999 Cysteine, glutathione, or hydrogen peroxide also increased nitrite accumulation in IL-1beta-stimulated VSMCs. Hydrogen Peroxide 26-43 interleukin 1 beta Rattus norvegicus 83-91 10069792-8 1999 Cysteine, glutathione, or hydrogen peroxide also increased nitrite accumulation in IL-1beta-stimulated VSMCs. Nitrites 59-66 interleukin 1 beta Rattus norvegicus 83-91 10069792-10 1999 CONCLUSIONS: Homocysteine enhances NO synthesis in IL-1beta-stimulated VSMCs, and oxidative products are involved in the effect of homocysteine. Homocysteine 13-25 interleukin 1 beta Rattus norvegicus 51-59 10030841-0 1999 Prostaglandin-E2 counteracts interleukin-1beta-stimulated upregulation of platelet-derived growth factor alpha-receptor on rat pulmonary myofibroblasts. Dinoprostone 0-16 interleukin 1 beta Rattus norvegicus 29-46 10030841-2 1999 Because IL-1beta stimulates prostaglandin (PG) E2 production, we investigated whether IL-1beta could upregulate PDGF-Ralpha via a PGE2-dependent mechanism. Dinoprostone 130-134 interleukin 1 beta Rattus norvegicus 86-94 10030841-3 1999 IL-1beta increased the production of PGE2 by rat lung myofibroblasts and the cyclooxygenase (COX) inhibitor indomethacin blocked IL-1beta-induced PGE2 production. Dinoprostone 37-41 interleukin 1 beta Rattus norvegicus 0-8 10030841-3 1999 IL-1beta increased the production of PGE2 by rat lung myofibroblasts and the cyclooxygenase (COX) inhibitor indomethacin blocked IL-1beta-induced PGE2 production. Dinoprostone 37-41 interleukin 1 beta Rattus norvegicus 129-137 10030841-3 1999 IL-1beta increased the production of PGE2 by rat lung myofibroblasts and the cyclooxygenase (COX) inhibitor indomethacin blocked IL-1beta-induced PGE2 production. Indomethacin 108-120 interleukin 1 beta Rattus norvegicus 129-137 10030841-3 1999 IL-1beta increased the production of PGE2 by rat lung myofibroblasts and the cyclooxygenase (COX) inhibitor indomethacin blocked IL-1beta-induced PGE2 production. Dinoprostone 146-150 interleukin 1 beta Rattus norvegicus 0-8 10030841-3 1999 IL-1beta increased the production of PGE2 by rat lung myofibroblasts and the cyclooxygenase (COX) inhibitor indomethacin blocked IL-1beta-induced PGE2 production. Dinoprostone 146-150 interleukin 1 beta Rattus norvegicus 129-137 10030841-5 1999 Instead, PGE2 downregulated PDGF-Ralpha protein and messenger RNA expression, and counteracted the IL-1beta-stimulated increase in [125I]PDGF-AA binding. Dinoprostone 9-13 interleukin 1 beta Rattus norvegicus 99-107 10030841-6 1999 Pretreatment of cells with indomethacin or the COX-2 specific inhibitor NS-398 attenuated the suppressive effect of exogenous PGE2 on PDGF-Ralpha, indicating that endogenous PGE2 released by IL-1beta treatment also contributed to downregulation of PDGF-Ralpha. Indomethacin 27-39 interleukin 1 beta Rattus norvegicus 191-199 10070167-0 1999 AVP inhibits LPS- and IL-1beta-stimulated NO and cGMP via V1 receptor in cultured rat mesangial cells. Cyclic GMP 49-53 interleukin 1 beta Rattus norvegicus 22-30 10030841-6 1999 Pretreatment of cells with indomethacin or the COX-2 specific inhibitor NS-398 attenuated the suppressive effect of exogenous PGE2 on PDGF-Ralpha, indicating that endogenous PGE2 released by IL-1beta treatment also contributed to downregulation of PDGF-Ralpha. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 72-78 interleukin 1 beta Rattus norvegicus 191-199 10070167-3 1999 AVP inhibited lipopolysaccharide (LPS)- and interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner, with concomitant changes in cGMP content, iNOS mRNA, and iNOS protein. Nitrites 81-88 interleukin 1 beta Rattus norvegicus 44-61 10070167-3 1999 AVP inhibited lipopolysaccharide (LPS)- and interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner, with concomitant changes in cGMP content, iNOS mRNA, and iNOS protein. Nitrites 81-88 interleukin 1 beta Rattus norvegicus 63-71 10030841-6 1999 Pretreatment of cells with indomethacin or the COX-2 specific inhibitor NS-398 attenuated the suppressive effect of exogenous PGE2 on PDGF-Ralpha, indicating that endogenous PGE2 released by IL-1beta treatment also contributed to downregulation of PDGF-Ralpha. Dinoprostone 126-130 interleukin 1 beta Rattus norvegicus 191-199 10030841-6 1999 Pretreatment of cells with indomethacin or the COX-2 specific inhibitor NS-398 attenuated the suppressive effect of exogenous PGE2 on PDGF-Ralpha, indicating that endogenous PGE2 released by IL-1beta treatment also contributed to downregulation of PDGF-Ralpha. Dinoprostone 174-178 interleukin 1 beta Rattus norvegicus 191-199 10030841-10 1999 Because IL-1beta upregulates both PGE2 production and PDGF-Ralpha expression, these data suggest that PGE2 functions in a negative feedback loop to limit expression of PDGF-Ralpha and suppress PDGF-stimulated myofibroblast proliferation. Dinoprostone 34-38 interleukin 1 beta Rattus norvegicus 8-16 10030841-10 1999 Because IL-1beta upregulates both PGE2 production and PDGF-Ralpha expression, these data suggest that PGE2 functions in a negative feedback loop to limit expression of PDGF-Ralpha and suppress PDGF-stimulated myofibroblast proliferation. Dinoprostone 102-106 interleukin 1 beta Rattus norvegicus 8-16 10371676-1 1999 Prostaglandins mediate the suppressive effects of interleukin-1beta. Prostaglandins 0-14 interleukin 1 beta Rattus norvegicus 50-67 10210774-0 1999 Synergism between interleukin-6 and interleukin-1beta in hypothalamic serotonin release: a reverse in vivo microdialysis study in F344 rats. Serotonin 70-79 interleukin 1 beta Rattus norvegicus 36-53 10209070-5 1999 IL-1beta (0.02 microg/pup, administered twice daily from postnatal day 1 to 4) induced marked elevation in plasma corticosterone (CORT) level as compared to controls and LPS groups (0.4 microg or 1.2 microg LPS/pup, injected once daily from postnatal day 1 to 4). Corticosterone 114-128 interleukin 1 beta Rattus norvegicus 0-8 10209070-5 1999 IL-1beta (0.02 microg/pup, administered twice daily from postnatal day 1 to 4) induced marked elevation in plasma corticosterone (CORT) level as compared to controls and LPS groups (0.4 microg or 1.2 microg LPS/pup, injected once daily from postnatal day 1 to 4). Corticosterone 130-134 interleukin 1 beta Rattus norvegicus 0-8 10210154-7 1999 RESULTS: Caerulein-induced pancreatitis (CIP) led to 42% decrease in DNA synthesis, 30% inhibition of PBF, as well as, a significant increase in pancreatic weight, plasma amylase activity, plasma interleukin-1beta concentration, and development of the histological signs of pancreatic damage (edema, leukocyte infiltration and vacuolization). Ceruletide 9-18 interleukin 1 beta Rattus norvegicus 196-213 10193805-0 1999 Human recombinant erythropoietin inhibits interleukin-1beta-stimulated nitric oxide and cyclic guanosine monophosphate production in cultured rat vascular smooth-muscle cells. Cyclic GMP 88-118 interleukin 1 beta Rattus norvegicus 42-59 10193805-5 1999 RESULTS: RHuEpo inhibited IL-1beta-induced nitrite production in a dose- and time-dependent manner with concomitant changes of intracellular cGMP contents. Nitrites 43-50 interleukin 1 beta Rattus norvegicus 26-34 10193805-0 1999 Human recombinant erythropoietin inhibits interleukin-1beta-stimulated nitric oxide and cyclic guanosine monophosphate production in cultured rat vascular smooth-muscle cells. Nitric Oxide 71-83 interleukin 1 beta Rattus norvegicus 42-59 10193805-8 1999 CONCLUSIONS: It is suggested that a pharmacological dose of rHuEpo inhibits IL-1beta-induced NO and cGMP production as well as iNOS mRNA expression, presumably via the Epo receptor. Cyclic GMP 100-104 interleukin 1 beta Rattus norvegicus 76-84 10081976-6 1999 This inhibition of LTP was blocked by IL-1beta tripeptide antagonist (Lys-D-Pro-Thr), suggesting that the inhibitory effect of mild ischemia on synaptic potentials and LTP may be mediated by the generation of IL-1beta. tripeptide K-26 47-57 interleukin 1 beta Rattus norvegicus 38-46 10064624-7 1999 Similarly, in a whole blood assay, GLY reduced TNF-alpha (P<0.0001) and IL-1beta (P<0.0001) synthesis and increased IL-10 expression (P<0.05) in a dose-dependent manner. Glycine 35-38 interleukin 1 beta Rattus norvegicus 75-83 10064624-9 1999 Furthermore, GLY decreased the amount of IL-1beta and TNF-alpha-specific mRNA. Glycine 13-16 interleukin 1 beta Rattus norvegicus 41-49 10081976-6 1999 This inhibition of LTP was blocked by IL-1beta tripeptide antagonist (Lys-D-Pro-Thr), suggesting that the inhibitory effect of mild ischemia on synaptic potentials and LTP may be mediated by the generation of IL-1beta. tripeptide K-26 47-57 interleukin 1 beta Rattus norvegicus 209-217 9916024-10 1999 Furthermore, treatment with a water-permeable form of cholesterol that bypasses the requirement for StAR partially restored hCG-stimulated testosterone secretion from testes isolated from rats treated icv with IL-1beta. Testosterone 139-151 interleukin 1 beta Rattus norvegicus 210-218 10028914-4 1999 Expression of IL-1beta by glial cells was investigated using immunocytochemistry 30 min to 7 days after infusion of the NMDA agonist cis-2,4-methanoglutamate (MGlu; 10 nmol) into the cortex. N-Methylaspartate 120-124 interleukin 1 beta Rattus norvegicus 14-22 10028914-4 1999 Expression of IL-1beta by glial cells was investigated using immunocytochemistry 30 min to 7 days after infusion of the NMDA agonist cis-2,4-methanoglutamate (MGlu; 10 nmol) into the cortex. trans-ABCD 133-157 interleukin 1 beta Rattus norvegicus 14-22 10028914-4 1999 Expression of IL-1beta by glial cells was investigated using immunocytochemistry 30 min to 7 days after infusion of the NMDA agonist cis-2,4-methanoglutamate (MGlu; 10 nmol) into the cortex. mglu 159-163 interleukin 1 beta Rattus norvegicus 14-22 9916024-0 1999 The inhibitory effect of intracerebroventricularly injected interleukin 1beta on testosterone secretion in the rat: role of steroidogenic acute regulatory protein. Testosterone 81-93 interleukin 1 beta Rattus norvegicus 60-77 9916024-8 1999 As the first acutely and hormonally regulated step in the biosynthesis of testosterone is the transfer of cholesterol into the inner mitochondrial membrane, which is mediated by steroidogenic acute regulatory (StAR) protein, we hypothesized that the rapid effects of icv IL-1beta on testicular responsiveness to hCG might be due to reduced levels of StAR. Testosterone 74-86 interleukin 1 beta Rattus norvegicus 271-279 9927320-12 1999 Because lysophosphatidylcholine (LPC) may function as a second messenger for IL-1beta, we also investigated the effects of LPC. Lysophosphatidylcholines 33-36 interleukin 1 beta Rattus norvegicus 77-85 9916024-8 1999 As the first acutely and hormonally regulated step in the biosynthesis of testosterone is the transfer of cholesterol into the inner mitochondrial membrane, which is mediated by steroidogenic acute regulatory (StAR) protein, we hypothesized that the rapid effects of icv IL-1beta on testicular responsiveness to hCG might be due to reduced levels of StAR. Cholesterol 106-117 interleukin 1 beta Rattus norvegicus 271-279 9916024-10 1999 Furthermore, treatment with a water-permeable form of cholesterol that bypasses the requirement for StAR partially restored hCG-stimulated testosterone secretion from testes isolated from rats treated icv with IL-1beta. Water 30-35 interleukin 1 beta Rattus norvegicus 210-218 9916024-10 1999 Furthermore, treatment with a water-permeable form of cholesterol that bypasses the requirement for StAR partially restored hCG-stimulated testosterone secretion from testes isolated from rats treated icv with IL-1beta. Cholesterol 54-65 interleukin 1 beta Rattus norvegicus 210-218 9927320-0 1999 Interleukin-1beta and catecholamines synergistically stimulate interleukin-6 release from rat C6 glioma cells in vitro: a potential role for lysophosphatidylcholine. Lysophosphatidylcholines 141-164 interleukin 1 beta Rattus norvegicus 0-17 9927320-5 1999 In the presence of (Bu)2cAMP, IL-1beta induced a strongly synergistic response with respect to IL-6 release; thus, the combination of these two agents resulted in a release of IL-6 that was much larger that the release attributed to either agent alone (i.e. 30-fold higher). (bu)2camp 19-28 interleukin 1 beta Rattus norvegicus 30-38 9927320-7 1999 Thus, increases in intracellular cAMP concentrations act in a synergistic fashion with the IL-1beta signaling pathway for IL-6 release. Cyclic AMP 33-37 interleukin 1 beta Rattus norvegicus 91-99 9927320-11 1999 The synergistic increases in IL-6 release caused by IL-1beta and isoproterenol as well as IL-1beta and norepinephrine were blocked by the pretreatment of C6 cells with the beta-receptor antagonist propranolol. Propranolol 197-208 interleukin 1 beta Rattus norvegicus 52-60 9927320-11 1999 The synergistic increases in IL-6 release caused by IL-1beta and isoproterenol as well as IL-1beta and norepinephrine were blocked by the pretreatment of C6 cells with the beta-receptor antagonist propranolol. Propranolol 197-208 interleukin 1 beta Rattus norvegicus 90-98 9927320-15 1999 Exposure of [3H]choline-labeled C6 cells to IL-1beta resulted in an increase in the [3H]LPC species as well as a decrease in [3H]phosphatidylcholine. Tritium 13-15 interleukin 1 beta Rattus norvegicus 44-52 9927320-15 1999 Exposure of [3H]choline-labeled C6 cells to IL-1beta resulted in an increase in the [3H]LPC species as well as a decrease in [3H]phosphatidylcholine. Choline 16-23 interleukin 1 beta Rattus norvegicus 44-52 9927320-15 1999 Exposure of [3H]choline-labeled C6 cells to IL-1beta resulted in an increase in the [3H]LPC species as well as a decrease in [3H]phosphatidylcholine. Tritium 85-87 interleukin 1 beta Rattus norvegicus 44-52 9927320-15 1999 Exposure of [3H]choline-labeled C6 cells to IL-1beta resulted in an increase in the [3H]LPC species as well as a decrease in [3H]phosphatidylcholine. 3h]phosphatidylcholine 126-148 interleukin 1 beta Rattus norvegicus 44-52 10211421-8 1999 RESULTS: Pretreatment with lexipafant, a potent PAF receptor antagonist, significantly reduced the pancreatitis-induced increase in pancreatic endothelial barrier dysfunction, pancreatic leukocyte recruitment and serum levels of IL-1 beta, although a difference persisted between animals with sham operation and pancreatitis. lexipafant 27-37 interleukin 1 beta Rattus norvegicus 229-238 9878736-10 1999 Taken together, these findings indicate that IL-1beta impairs lung clearance of MADB106 tumor cells via the actions of adrenal catecholamines, most likely epinephrine, acting at beta-adrenergic receptors in the periphery. Catecholamines 127-141 interleukin 1 beta Rattus norvegicus 45-53 10224371-8 1999 In addition, Ro 31-8220 (a PKC inhibitor) inhibited OX8-induced iNOS upregulation, NO and IL-1beta production, but did not inhibit TNF-alpha production. Ro 31-8220 13-23 interleukin 1 beta Rattus norvegicus 90-98 10224371-8 1999 In addition, Ro 31-8220 (a PKC inhibitor) inhibited OX8-induced iNOS upregulation, NO and IL-1beta production, but did not inhibit TNF-alpha production. ox8 52-55 interleukin 1 beta Rattus norvegicus 90-98 10048466-6 1999 injection of various doses of LPS, mRNA for the immediate-early gene IkappaBu (an inhibitor of NF-kappaB, a transcription factor that regulates the expression of many pro-inflammatory cytokines) was induced in the anterior lobe as early as 0.5 h. The induced IkappaBalpha mRNA expression peaked at 1 h. In the posterior lobe, IkappaBalpha mRNA was first induced at 0.5 h and peaked at 2 h. A similar spatiotemporal pattern of interleukin-1b (IL-1) mRNA induction was observed. ikappabu 69-77 interleukin 1 beta Rattus norvegicus 426-440 10636471-6 1999 Using phosphorothioate-oligonucleotides against initiation codon significantly reduced the protein levels of APP induced by NGF and IL-1beta to basal level in PC12 cell culture systems. Phosphorothioate Oligonucleotides 6-39 interleukin 1 beta Rattus norvegicus 132-140 9933502-0 1999 Prostaglandin E2 mediates activation of hypothalamic histamine by interleukin-1beta in rats. Dinoprostone 0-16 interleukin 1 beta Rattus norvegicus 66-83 9933502-0 1999 Prostaglandin E2 mediates activation of hypothalamic histamine by interleukin-1beta in rats. Histamine 53-62 interleukin 1 beta Rattus norvegicus 66-83 9933502-1 1999 The present study was designed to investigate the effects of peripheral interleukin-1beta (IL-1beta) on hypothalamic histamine (HA) systems. Histamine 117-126 interleukin 1 beta Rattus norvegicus 72-89 9933502-1 1999 The present study was designed to investigate the effects of peripheral interleukin-1beta (IL-1beta) on hypothalamic histamine (HA) systems. Histamine 117-126 interleukin 1 beta Rattus norvegicus 91-99 9933502-2 1999 Intraperitoneal injection of IL-1beta increased the turnover rate of hypothalamic HA, which was assessed by accumulation of tele-methylhistamine after pargyline treatment. tele-methylhistamine 124-144 interleukin 1 beta Rattus norvegicus 29-37 9933502-2 1999 Intraperitoneal injection of IL-1beta increased the turnover rate of hypothalamic HA, which was assessed by accumulation of tele-methylhistamine after pargyline treatment. Pargyline 151-160 interleukin 1 beta Rattus norvegicus 29-37 9933502-4 1999 Pretreatment with indomethacin completely blocked the effects induced by IL-1beta on hypothalamic HA. Indomethacin 18-30 interleukin 1 beta Rattus norvegicus 73-81 9933502-6 1999 These results indicate that hypothalamic PGE2 activated by peripheral administration of IL-1beta, but not by peripheral PGE2, may enhance synthesis and release of hypothalamic HA by activation of HDC, and may facilitate degradation of extracellular histamine by activation of HMT. Dinoprostone 41-45 interleukin 1 beta Rattus norvegicus 88-96 9933502-6 1999 These results indicate that hypothalamic PGE2 activated by peripheral administration of IL-1beta, but not by peripheral PGE2, may enhance synthesis and release of hypothalamic HA by activation of HDC, and may facilitate degradation of extracellular histamine by activation of HMT. Histamine 249-258 interleukin 1 beta Rattus norvegicus 88-96 9887027-1 1999 The possible mechanism by which interleukin-1beta (IL-1beta) affects beta-adrenergic responsiveness of L-type Ca2+ current (ICa,L) was examined in adult rat ventricular myocytes by use of whole cell patch-clamp techniques. isocyanic acid 124-127 interleukin 1 beta Rattus norvegicus 32-49 9887027-1 1999 The possible mechanism by which interleukin-1beta (IL-1beta) affects beta-adrenergic responsiveness of L-type Ca2+ current (ICa,L) was examined in adult rat ventricular myocytes by use of whole cell patch-clamp techniques. isocyanic acid 124-127 interleukin 1 beta Rattus norvegicus 51-59 9887027-2 1999 In the presence of isoproterenol (Iso), exposure for 3 min to IL-1beta suppressed the Iso-activated ICa,L. Isoproterenol 19-32 interleukin 1 beta Rattus norvegicus 62-70 9887027-2 1999 In the presence of isoproterenol (Iso), exposure for 3 min to IL-1beta suppressed the Iso-activated ICa,L. Isoproterenol 34-37 interleukin 1 beta Rattus norvegicus 62-70 9887027-3 1999 In the presence of IL-1beta, the response of ICa,L to Iso was decreased, and the EC50 for Iso stimulation was increased. isocyanic acid 45-48 interleukin 1 beta Rattus norvegicus 19-27 9887027-3 1999 In the presence of IL-1beta, the response of ICa,L to Iso was decreased, and the EC50 for Iso stimulation was increased. Isoproterenol 54-57 interleukin 1 beta Rattus norvegicus 19-27 10433070-8 1999 (3) In combination, AG completely blocked IL-1beta increased nitrite production, reversed IL-1beta inhibited insulin release by approximately 50%, completely reversed IL-1beta increased HSP-70 expression, but did not reverse IL-1beta inhibited GAD-65 expression. Nitrites 61-68 interleukin 1 beta Rattus norvegicus 42-50 10433070-0 1999 Nitric oxide mediates IL-1beta stimulation of heat shock protein but not IL-1beta inhibition of glutamic acid decarboxylase. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 22-30 10433070-6 1999 We found that (1) IL-1beta at 10 U/ml increased nitrite production, inhibited insulin release, increased HSP-70 expression and decreased GAD-65 expression. Nitrites 48-55 interleukin 1 beta Rattus norvegicus 18-26 9930728-10 1999 PGE2 and the EP2 agonists reduced IL-1beta production. Dinoprostone 0-4 interleukin 1 beta Rattus norvegicus 34-42 9930728-12 1999 The adenylyl cyclase activator forskolin and the cAMP analogue dibutyryl cAMP also reduced IL-1beta production. Colforsin 31-40 interleukin 1 beta Rattus norvegicus 91-99 9930728-12 1999 The adenylyl cyclase activator forskolin and the cAMP analogue dibutyryl cAMP also reduced IL-1beta production. Cyclic AMP 49-53 interleukin 1 beta Rattus norvegicus 91-99 9930728-12 1999 The adenylyl cyclase activator forskolin and the cAMP analogue dibutyryl cAMP also reduced IL-1beta production. Bucladesine 63-77 interleukin 1 beta Rattus norvegicus 91-99 9878736-8 1999 The effect of IL-1beta on lung clearance was blocked by pretreatment with the beta-adrenergic antagonist, nadolol (0.5 mg/kg), but not by the alpha-antagonist phentolamine (5 mg/kg). Nadolol 106-113 interleukin 1 beta Rattus norvegicus 14-22 9878736-10 1999 Taken together, these findings indicate that IL-1beta impairs lung clearance of MADB106 tumor cells via the actions of adrenal catecholamines, most likely epinephrine, acting at beta-adrenergic receptors in the periphery. Epinephrine 155-166 interleukin 1 beta Rattus norvegicus 45-53 10352396-6 1999 Adequate biological activity of the infused rIL-1beta was supported by elevated rectal temperature records and significant elevations of plasma corticosterone on day 14. Corticosterone 144-158 interleukin 1 beta Rattus norvegicus 44-53 10761541-5 1999 However, both IL-1 beta and G-CSF caused a significant increase (p < 0.05) in nitrite levels at 48 h. NG-L-arginine-methyl-ester was used to inhibit nitrite production induced by G-CSF and this implicated nitric oxide synthase activity. Nitrites 81-88 interleukin 1 beta Rattus norvegicus 14-23 10761541-6 1999 When G-CSF and IL-1 beta were used in a combined treatment, nitrite levels were significantly increased (p < 0.05) at both 24 and 48 h. Both IL-3 alone and in combination with IL-1 beta caused elevated PGE2 production in this model. Nitrites 60-67 interleukin 1 beta Rattus norvegicus 179-188 10761541-5 1999 However, both IL-1 beta and G-CSF caused a significant increase (p < 0.05) in nitrite levels at 48 h. NG-L-arginine-methyl-ester was used to inhibit nitrite production induced by G-CSF and this implicated nitric oxide synthase activity. ng-l-arginine-methyl-ester 105-131 interleukin 1 beta Rattus norvegicus 14-23 10761541-6 1999 When G-CSF and IL-1 beta were used in a combined treatment, nitrite levels were significantly increased (p < 0.05) at both 24 and 48 h. Both IL-3 alone and in combination with IL-1 beta caused elevated PGE2 production in this model. Dinoprostone 205-209 interleukin 1 beta Rattus norvegicus 15-24 10761541-6 1999 When G-CSF and IL-1 beta were used in a combined treatment, nitrite levels were significantly increased (p < 0.05) at both 24 and 48 h. Both IL-3 alone and in combination with IL-1 beta caused elevated PGE2 production in this model. Dinoprostone 205-209 interleukin 1 beta Rattus norvegicus 179-188 10761541-7 1999 PGE2 levels were also significantly increased by stimulation with GM-CSF and IL-3 combined with IL-1 beta. Dinoprostone 0-4 interleukin 1 beta Rattus norvegicus 96-105 10761541-5 1999 However, both IL-1 beta and G-CSF caused a significant increase (p < 0.05) in nitrite levels at 48 h. NG-L-arginine-methyl-ester was used to inhibit nitrite production induced by G-CSF and this implicated nitric oxide synthase activity. Nitrites 152-159 interleukin 1 beta Rattus norvegicus 14-23 10761541-6 1999 When G-CSF and IL-1 beta were used in a combined treatment, nitrite levels were significantly increased (p < 0.05) at both 24 and 48 h. Both IL-3 alone and in combination with IL-1 beta caused elevated PGE2 production in this model. Nitrites 60-67 interleukin 1 beta Rattus norvegicus 15-24 9933740-7 1999 In the control group injected with saline solution, mRNA expressions of iNOS, IL-1beta and TNF-alpha were absent. Sodium Chloride 35-41 interleukin 1 beta Rattus norvegicus 78-86 10391466-0 1999 Interleukin-1beta activates forebrain glial cells and increases nitric oxide production and cortical glutamate and GABA release in vivo: implications for Alzheimer"s disease. Nitric Oxide 64-76 interleukin 1 beta Rattus norvegicus 0-17 9932681-12 1999 Administration of L-arginine after trauma-hemorrhage, however, improved splenic and peritoneal macrophage IL-1beta and IL-6 release. Arginine 18-28 interleukin 1 beta Rattus norvegicus 106-114 10321717-0 1999 Interleukin-1beta causes different levels of nitric oxide-mediated depression of contractility in different positions of rat thoracic aorta. Nitric Oxide 45-57 interleukin 1 beta Rattus norvegicus 0-17 10321717-6 1999 S-methylisothiourea sulfate (SMT), an iNOS inhibitor, completely blocked the depression of contraction caused by IL-1beta in intact aortic rings. S-methylisothiopseudouronium 0-27 interleukin 1 beta Rattus norvegicus 113-121 10321717-6 1999 S-methylisothiourea sulfate (SMT), an iNOS inhibitor, completely blocked the depression of contraction caused by IL-1beta in intact aortic rings. S-methylisothiopseudouronium 29-32 interleukin 1 beta Rattus norvegicus 113-121 9930928-9 1999 BB/S-R islets cultured for 24 hr in IL-1beta (10(-13) M) maintained a significant insulin secretory response to glucose in contrast to Wistar controls in which the response was completely inhibited. Glucose 112-119 interleukin 1 beta Rattus norvegicus 36-44 9930928-10 1999 Nitrite production was induced by IL-1beta, in a dose-dependent manner, in control islets whereas there was no significant increase in production in the islets of BB/S-R rats. Nitrites 0-7 interleukin 1 beta Rattus norvegicus 34-42 10403504-0 1999 Interleukin-1beta-induced nitric oxide production in rat aortic endothelial cells: inhibition by estradiol in normal and high glucose cultures. Nitric Oxide 26-38 interleukin 1 beta Rattus norvegicus 0-17 10403504-0 1999 Interleukin-1beta-induced nitric oxide production in rat aortic endothelial cells: inhibition by estradiol in normal and high glucose cultures. Estradiol 97-106 interleukin 1 beta Rattus norvegicus 0-17 10403504-0 1999 Interleukin-1beta-induced nitric oxide production in rat aortic endothelial cells: inhibition by estradiol in normal and high glucose cultures. Glucose 126-133 interleukin 1 beta Rattus norvegicus 0-17 10403504-3 1999 In the current study, we examined the effect of physiological concentrations of estradiol on interleukin-1beta (IL-1beta)-induced NO production in rat aortic endothelial cells (RAECs). Estradiol 80-89 interleukin 1 beta Rattus norvegicus 93-110 10403504-3 1999 In the current study, we examined the effect of physiological concentrations of estradiol on interleukin-1beta (IL-1beta)-induced NO production in rat aortic endothelial cells (RAECs). Estradiol 80-89 interleukin 1 beta Rattus norvegicus 112-120 10403504-4 1999 17Beta-estradiol significantly decreased IL-1beta-induced iNOS protein levels and reduced NO production in RAECs. Estradiol 0-16 interleukin 1 beta Rattus norvegicus 41-49 10403504-5 1999 High glucose (25 mM) elevated the increase in IL-1beta-induced iNOS protein and NO production. Glucose 5-12 interleukin 1 beta Rattus norvegicus 46-54 10403504-6 1999 Nevertheless, estradiol still inhibited IL-1beta-induced iNOS and NO production even in the presence of high glucose. Estradiol 14-23 interleukin 1 beta Rattus norvegicus 40-48 10403504-6 1999 Nevertheless, estradiol still inhibited IL-1beta-induced iNOS and NO production even in the presence of high glucose. Glucose 109-116 interleukin 1 beta Rattus norvegicus 40-48 10363820-1 1999 The effects of systemically administered interleukin-1beta (1.0 microg), interleukin-6 (1.0 microg) and interleukin-2 (1.0 microg) on in vivo variations of monoamines were assessed in the nucleus accumbens. monoamines 156-166 interleukin 1 beta Rattus norvegicus 41-58 10363820-2 1999 Administration of interleukin-1beta did not affect extracellular accumbal dopamine, provoked a modest rise of homovanillic acid, and prevented the decline of dihydroxyphenylacetic acid ordinarily seen in saline treated rats. Homovanillic Acid 110-127 interleukin 1 beta Rattus norvegicus 18-35 10363820-2 1999 Administration of interleukin-1beta did not affect extracellular accumbal dopamine, provoked a modest rise of homovanillic acid, and prevented the decline of dihydroxyphenylacetic acid ordinarily seen in saline treated rats. 3,4-Dihydroxyphenylacetic Acid 158-184 interleukin 1 beta Rattus norvegicus 18-35 10363820-2 1999 Administration of interleukin-1beta did not affect extracellular accumbal dopamine, provoked a modest rise of homovanillic acid, and prevented the decline of dihydroxyphenylacetic acid ordinarily seen in saline treated rats. Sodium Chloride 204-210 interleukin 1 beta Rattus norvegicus 18-35 10430470-0 1999 The P38 mitogen-activated protein kinase inhibitor SB203580 antagonizes the inhibitory effects of interleukin-1beta on long-term potentiation in the rat dentate gyrus in vitro. SB 203580 51-59 interleukin 1 beta Rattus norvegicus 98-115 10391466-0 1999 Interleukin-1beta activates forebrain glial cells and increases nitric oxide production and cortical glutamate and GABA release in vivo: implications for Alzheimer"s disease. Glutamic Acid 101-110 interleukin 1 beta Rattus norvegicus 0-17 10430470-5 1999 This action of interleukin-1beta on long-term potentiation, as well as an inhibition of N-methyl-D aspartate receptor-mediated field potentials, was attenuated by pre-treatment of slices with the p38 mitogen-associated protein kinase inhibitor SB203580 (1 microM). SB 203580 244-252 interleukin 1 beta Rattus norvegicus 15-32 10430470-8 1999 The cyclooxygenase inhibitor indomethacin (50 microM) was found to attenuate the interleukin-1beta-induced effects on both long-term potentiation and N-methyl-D-aspartate receptor-mediated field potentials. Indomethacin 29-41 interleukin 1 beta Rattus norvegicus 81-98 10391466-0 1999 Interleukin-1beta activates forebrain glial cells and increases nitric oxide production and cortical glutamate and GABA release in vivo: implications for Alzheimer"s disease. gamma-Aminobutyric Acid 115-119 interleukin 1 beta Rattus norvegicus 0-17 9843865-2 1998 Because the increase in local synthesis of PGE2 is assumed to be a necessary process in a fever caused by central injection of interleukin-1beta (IL-1beta), an EP1 receptor antagonist (SC-19220) should inhibit the IL-1beta-induced fever. Dinoprostone 43-47 interleukin 1 beta Rattus norvegicus 127-144 10473257-0 1999 Immunohistochemical localization of interleukin-1beta, interleukin-1 receptor antagonist and interleukin-1beta converting enzyme/caspase-1 in the rat brain after peripheral administration of kainic acid. Kainic Acid 191-202 interleukin 1 beta Rattus norvegicus 93-110 10473257-9 1999 Our results show that the induction of IL-1beta and IL-1 receptor antagonist proteins after kainic acid are closely associated with the temporal as well as the anatomical distribution of in situ end-labelled neurons, whereas the induction of caspase-1 protein exhibited a delayed temporal profile and limited distribution. Kainic Acid 92-103 interleukin 1 beta Rattus norvegicus 39-47 10634305-0 1999 Hepatic heme metabolism in rats with fever induced by interleukin 1beta. Heme 8-12 interleukin 1 beta Rattus norvegicus 54-71 10392855-7 1999 Previous exposure to interleukin-1beta or footshocks enhanced adrenocorticotropic hormone and corticosterone responses, but did not affect the long-term locomotor sensitization to amphetamine. Corticosterone 94-108 interleukin 1 beta Rattus norvegicus 21-38 9843912-6 1998 In addition to its inhibitory effect on Na+ transport, chronic IL-1beta exposure increased both basal and cAMP-stimulated anion secretion rates. Cyclic AMP 106-110 interleukin 1 beta Rattus norvegicus 63-71 9843865-2 1998 Because the increase in local synthesis of PGE2 is assumed to be a necessary process in a fever caused by central injection of interleukin-1beta (IL-1beta), an EP1 receptor antagonist (SC-19220) should inhibit the IL-1beta-induced fever. Dinoprostone 43-47 interleukin 1 beta Rattus norvegicus 146-154 9843865-6 1998 These findings suggest that the central IL-1beta-induced fever in rats is mediated, at least partly, by activation of EP1 receptors by PGE2. Dinoprostone 135-139 interleukin 1 beta Rattus norvegicus 40-48 9820830-0 1998 Interleukin 1beta decreases prostacyclin synthase activity in rat mesangial cells via endogenous peroxynitrite formation. Peroxynitrous Acid 97-110 interleukin 1 beta Rattus norvegicus 0-17 9820830-5 1998 Pretreatment of RMC with interleukin 1beta (IL-1beta), which up-regulated cyclo-oxygenase 2 and inducible nitric oxide synthase (NOS-2), significantly attenuated the conversion of [14C]prostaglandin H2 (PGH2) into the stable prostacyclin (PGI2) metabolite 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha). 6-Ketoprostaglandin F1 alpha 256-283 interleukin 1 beta Rattus norvegicus 25-42 9820830-5 1998 Pretreatment of RMC with interleukin 1beta (IL-1beta), which up-regulated cyclo-oxygenase 2 and inducible nitric oxide synthase (NOS-2), significantly attenuated the conversion of [14C]prostaglandin H2 (PGH2) into the stable prostacyclin (PGI2) metabolite 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha). rmc 16-19 interleukin 1 beta Rattus norvegicus 25-42 9820830-5 1998 Pretreatment of RMC with interleukin 1beta (IL-1beta), which up-regulated cyclo-oxygenase 2 and inducible nitric oxide synthase (NOS-2), significantly attenuated the conversion of [14C]prostaglandin H2 (PGH2) into the stable prostacyclin (PGI2) metabolite 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha). 6-Ketoprostaglandin F1 alpha 256-283 interleukin 1 beta Rattus norvegicus 44-52 9820830-5 1998 Pretreatment of RMC with interleukin 1beta (IL-1beta), which up-regulated cyclo-oxygenase 2 and inducible nitric oxide synthase (NOS-2), significantly attenuated the conversion of [14C]prostaglandin H2 (PGH2) into the stable prostacyclin (PGI2) metabolite 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha). 6-Ketoprostaglandin F1 alpha 285-300 interleukin 1 beta Rattus norvegicus 25-42 9820830-5 1998 Pretreatment of RMC with interleukin 1beta (IL-1beta), which up-regulated cyclo-oxygenase 2 and inducible nitric oxide synthase (NOS-2), significantly attenuated the conversion of [14C]prostaglandin H2 (PGH2) into the stable prostacyclin (PGI2) metabolite 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha). 6-Ketoprostaglandin F1 alpha 285-300 interleukin 1 beta Rattus norvegicus 44-52 9820830-10 1998 In addition, immunoprecipitation of nitrotyrosine-containing proteins from PON- and SIN-1-treated RMC yielded distinct nitrated PGIS bands but also from IL-1beta-pretreated cells alone, compared with a lack of nitrated PGIS in control cells. 3-nitrotyrosine 36-49 interleukin 1 beta Rattus norvegicus 153-161 9820830-5 1998 Pretreatment of RMC with interleukin 1beta (IL-1beta), which up-regulated cyclo-oxygenase 2 and inducible nitric oxide synthase (NOS-2), significantly attenuated the conversion of [14C]prostaglandin H2 (PGH2) into the stable prostacyclin (PGI2) metabolite 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha). rmc 16-19 interleukin 1 beta Rattus norvegicus 44-52 9820830-5 1998 Pretreatment of RMC with interleukin 1beta (IL-1beta), which up-regulated cyclo-oxygenase 2 and inducible nitric oxide synthase (NOS-2), significantly attenuated the conversion of [14C]prostaglandin H2 (PGH2) into the stable prostacyclin (PGI2) metabolite 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha). Hydrogen 199-201 interleukin 1 beta Rattus norvegicus 25-42 9820830-5 1998 Pretreatment of RMC with interleukin 1beta (IL-1beta), which up-regulated cyclo-oxygenase 2 and inducible nitric oxide synthase (NOS-2), significantly attenuated the conversion of [14C]prostaglandin H2 (PGH2) into the stable prostacyclin (PGI2) metabolite 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha). Hydrogen 199-201 interleukin 1 beta Rattus norvegicus 44-52 9820830-5 1998 Pretreatment of RMC with interleukin 1beta (IL-1beta), which up-regulated cyclo-oxygenase 2 and inducible nitric oxide synthase (NOS-2), significantly attenuated the conversion of [14C]prostaglandin H2 (PGH2) into the stable prostacyclin (PGI2) metabolite 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha). Epoprostenol 225-237 interleukin 1 beta Rattus norvegicus 25-42 9820830-5 1998 Pretreatment of RMC with interleukin 1beta (IL-1beta), which up-regulated cyclo-oxygenase 2 and inducible nitric oxide synthase (NOS-2), significantly attenuated the conversion of [14C]prostaglandin H2 (PGH2) into the stable prostacyclin (PGI2) metabolite 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha). Epoprostenol 225-237 interleukin 1 beta Rattus norvegicus 44-52 9820830-5 1998 Pretreatment of RMC with interleukin 1beta (IL-1beta), which up-regulated cyclo-oxygenase 2 and inducible nitric oxide synthase (NOS-2), significantly attenuated the conversion of [14C]prostaglandin H2 (PGH2) into the stable prostacyclin (PGI2) metabolite 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha). Epoprostenol 239-243 interleukin 1 beta Rattus norvegicus 25-42 9820830-5 1998 Pretreatment of RMC with interleukin 1beta (IL-1beta), which up-regulated cyclo-oxygenase 2 and inducible nitric oxide synthase (NOS-2), significantly attenuated the conversion of [14C]prostaglandin H2 (PGH2) into the stable prostacyclin (PGI2) metabolite 6-oxo-prostaglandin F1alpha (6-oxo-PGF1alpha). Epoprostenol 239-243 interleukin 1 beta Rattus norvegicus 44-52 9813238-2 1998 IL-1beta and exposure to inescapable tail shock (IS) activate acute phase responses (APRs) that include increases in core body temperature (CBT), increases in hypothalamic-pituitary-adrenal activity, decreases in carrier proteins such as corticosterone binding globulin (CBG), aphagia and adipsia. N,N-BIS(4-CHLOROBENZYL)-1H-1,2,3,4-TETRAAZOL-5-AMINE 140-143 interleukin 1 beta Rattus norvegicus 0-8 9862447-2 1998 Interleukin-1beta (IL-1beta) is known to stimulate ceramide formation in rat renal mesangial cells; however, the respective subtype of SMase and its regulation have not been investigated. Ceramides 51-59 interleukin 1 beta Rattus norvegicus 0-17 9862447-2 1998 Interleukin-1beta (IL-1beta) is known to stimulate ceramide formation in rat renal mesangial cells; however, the respective subtype of SMase and its regulation have not been investigated. Ceramides 51-59 interleukin 1 beta Rattus norvegicus 19-27 9862447-3 1998 We found that IL-1beta induced an increase in endogenous ceramide levels via the action of a neutral SMase but not an acidic SMase in rat mesangial cells. Ceramides 57-65 interleukin 1 beta Rattus norvegicus 14-22 9862447-6 1998 Long-term incubation (24 h) of mesangial cells with TPA, which downregulates PKC-alpha, -delta, and -epsilon isoenzymes, resulted in a recovery of IL-1beta-stimulated neutral SMase activity as well as ceramide formation. Tetradecanoylphorbol Acetate 52-55 interleukin 1 beta Rattus norvegicus 147-155 9862447-6 1998 Long-term incubation (24 h) of mesangial cells with TPA, which downregulates PKC-alpha, -delta, and -epsilon isoenzymes, resulted in a recovery of IL-1beta-stimulated neutral SMase activity as well as ceramide formation. Ceramides 201-209 interleukin 1 beta Rattus norvegicus 147-155 9862447-7 1998 These data implicate an important modulatory function of PKC in ceramide production in IL-1beta-activated mesangial cells. Ceramides 64-72 interleukin 1 beta Rattus norvegicus 87-95 10023260-7 1998 In addition, after the percolated application of formocresol to experimentally induced periapical lesions, numerous macrophages expressing IL-1 beta became conspicuous within the vicinity of the extensive bone resorption sites. formocresol 49-60 interleukin 1 beta Rattus norvegicus 139-148 9879668-0 1998 The inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta stimulate phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. Phosphatidylcholines 87-106 interleukin 1 beta Rattus norvegicus 59-76 9879668-5 1998 These results suggest that tumor necrosis factor alpha or interleukin-1beta stimulate phosphatidylcholine secretion via protein kinase C activation in a Ca2+-independent manner. Phosphatidylcholines 86-105 interleukin 1 beta Rattus norvegicus 58-75 9813261-4 1998 Propentofylline inhibited lipopolysaccharide (LPS)-induced release of both tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta in a dose-dependent manner within the therapeutic low micromolar range. propentofylline 0-15 interleukin 1 beta Rattus norvegicus 113-135 9791055-2 1998 PX treatment prevented the increase in plasma tumor necrosis factor (TNF)-alpha (peak 1.5 h after the infection) and resulted in an 84 and 61% inhibition of plasma interleukin (IL)-1beta and IL-6, respectively (peaks at 3 h). Pentoxifylline 0-2 interleukin 1 beta Rattus norvegicus 164-186 9824295-0 1998 Inhibition of Ca2+-independent phospholipase A2 by bromoenol lactone attenuates prostaglandin generation induced by interleukin-1 beta and dibutyryl cAMP in rat mesangial cells. 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one 51-68 interleukin 1 beta Rattus norvegicus 116-134 9806750-2 1998 It was previously shown that exposure of rats to mild inescapable electrical footshock stress (20 min, 4 shocks/min, 5 s/shock, 0.8 mAmp) leads to apparent changes in the activity of AMs upon stimulation, reflected by an enhanced interleukin-1beta and tumor necrosis factor-alpha secretion and decreased nitric oxide secretion compared with the secretion by AMs isolated from nonstressed rats. Nitric Oxide 304-316 interleukin 1 beta Rattus norvegicus 230-279 9815040-7 1998 However, when parietal cells were preincubated with IL-1beta (0.5-5 pg/ml) for 10 min before the addition of histamine or carbachol, the response to these secretagogues was reduced by 35 and 67%, respectively. Histamine 109-118 interleukin 1 beta Rattus norvegicus 52-60 9815040-7 1998 However, when parietal cells were preincubated with IL-1beta (0.5-5 pg/ml) for 10 min before the addition of histamine or carbachol, the response to these secretagogues was reduced by 35 and 67%, respectively. Carbachol 122-131 interleukin 1 beta Rattus norvegicus 52-60 9815040-9 1998 Preincubation of parietal cells with IL-1beta failed to alter histamine-stimulated cAMP production but markedly inhibited carbachol-induced formation of D-myo-inositol 1,4, 5-trisphosphate. Carbachol 122-131 interleukin 1 beta Rattus norvegicus 37-45 9815040-9 1998 Preincubation of parietal cells with IL-1beta failed to alter histamine-stimulated cAMP production but markedly inhibited carbachol-induced formation of D-myo-inositol 1,4, 5-trisphosphate. Inositol 1,4,5-Trisphosphate 153-188 interleukin 1 beta Rattus norvegicus 37-45 9815040-10 1998 In fura 2-loaded, purified parietal cells, 10 min preincubation with IL-1beta dramatically reduced the initial transient peak elevation of intracellular Ca2+ concentration in response to carbachol. Fura-2 3-9 interleukin 1 beta Rattus norvegicus 69-77 9815040-10 1998 In fura 2-loaded, purified parietal cells, 10 min preincubation with IL-1beta dramatically reduced the initial transient peak elevation of intracellular Ca2+ concentration in response to carbachol. Carbachol 187-196 interleukin 1 beta Rattus norvegicus 69-77 9812920-4 1998 Electrophoretic mobility shift assay using synthetic oligonucleotide corresponding to the downstream NF-kappaB site of rat iNOS promoter as a probe showed that NOR3 inhibited IL-1beta-induced NF-kappaB activation and its nuclear translocation, as demonstrated with immunocytochemical study. Oligonucleotides 53-68 interleukin 1 beta Rattus norvegicus 175-183 9812920-7 1998 A proteasome inhibitor (MG115) blocked IL-1beta-induced transient degradation of IkappaB-alpha and stabilized the appearance of phosphorylated IkappaB-alpha stimulated by IL-1beta. carbobenzoxy-leucyl-leucyl-norvalinal 24-29 interleukin 1 beta Rattus norvegicus 39-47 9812920-7 1998 A proteasome inhibitor (MG115) blocked IL-1beta-induced transient degradation of IkappaB-alpha and stabilized the appearance of phosphorylated IkappaB-alpha stimulated by IL-1beta. carbobenzoxy-leucyl-leucyl-norvalinal 24-29 interleukin 1 beta Rattus norvegicus 171-179 9812920-8 1998 NOR3 inhibited the appearance of IL-1beta-induced phosphorylated IkappaB-alpha even in the presence of MG115. carbobenzoxy-leucyl-leucyl-norvalinal 103-108 interleukin 1 beta Rattus norvegicus 33-41 9791060-6 1998 The differential fever response seems to be mainly linked to the ovarian hormonal levels because bilaterally ovariectomized females, supplemented with sequential injections of estradiol 17beta and progesterone, showed a significantly higher IL-1beta fever than did ovariectomized rats receiving estradiol 17beta only. Estradiol 176-192 interleukin 1 beta Rattus norvegicus 241-249 9791060-6 1998 The differential fever response seems to be mainly linked to the ovarian hormonal levels because bilaterally ovariectomized females, supplemented with sequential injections of estradiol 17beta and progesterone, showed a significantly higher IL-1beta fever than did ovariectomized rats receiving estradiol 17beta only. Progesterone 197-209 interleukin 1 beta Rattus norvegicus 241-249 9791060-6 1998 The differential fever response seems to be mainly linked to the ovarian hormonal levels because bilaterally ovariectomized females, supplemented with sequential injections of estradiol 17beta and progesterone, showed a significantly higher IL-1beta fever than did ovariectomized rats receiving estradiol 17beta only. Estradiol 295-311 interleukin 1 beta Rattus norvegicus 241-249 9815044-7 1998 In a culture of isolated ulcer base, blockade of IL-1beta and TNF-alpha reduced COX-2 mRNA expression and PGE2 production. Dinoprostone 106-110 interleukin 1 beta Rattus norvegicus 49-57 9832392-8 1998 These data suggest that acute administration of interleukin-1beta inhibits the ascending and descending contractile reflex pathway and this effect seems not to be mediated by prostaglandins or histamine receptors. Prostaglandins 175-189 interleukin 1 beta Rattus norvegicus 48-65 9824295-0 1998 Inhibition of Ca2+-independent phospholipase A2 by bromoenol lactone attenuates prostaglandin generation induced by interleukin-1 beta and dibutyryl cAMP in rat mesangial cells. Prostaglandins 80-93 interleukin 1 beta Rattus norvegicus 116-134 9824295-3 1998 The results showed that bromoenol lactone, a relatively selective iPLA2 inhibitor, significantly attenuated prostaglandin E2 generation induced by interleukin-1beta and dibutyryl cAMP in parallel with the inhibition of iPLA2 activity. 6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one 24-41 interleukin 1 beta Rattus norvegicus 147-164 9824295-3 1998 The results showed that bromoenol lactone, a relatively selective iPLA2 inhibitor, significantly attenuated prostaglandin E2 generation induced by interleukin-1beta and dibutyryl cAMP in parallel with the inhibition of iPLA2 activity. Dinoprostone 108-124 interleukin 1 beta Rattus norvegicus 147-164 9784921-11 1998 The increases in both colon temperature and hypothalamic 5-HT release produced by interleukin-1 beta injection were attenuated by treatment with magnolol. magnolol 145-153 interleukin 1 beta Rattus norvegicus 82-100 9746498-7 1998 TNF-alpha and IL-1beta together enhanced synergistically cytosolic and membrane PLA2 activities and arachidonic acid release that were blocked differentially by MAFP and BEL, respectively, and inhibited completely by MAFP plus BEL. Arachidonic Acid 100-116 interleukin 1 beta Rattus norvegicus 14-22 9786861-1 1998 The inflammatory cytokine interleukin-1beta (IL-1beta) induces cyclooxygenase-2 (Cox-2) expression with a concomitant release of prostaglandins from glomerular mesangial cells. Prostaglandins 129-143 interleukin 1 beta Rattus norvegicus 26-43 9786861-1 1998 The inflammatory cytokine interleukin-1beta (IL-1beta) induces cyclooxygenase-2 (Cox-2) expression with a concomitant release of prostaglandins from glomerular mesangial cells. Prostaglandins 129-143 interleukin 1 beta Rattus norvegicus 45-53 9786861-2 1998 We reported previously that IL-1beta rapidly activates the c-Jun NH2-terminal/stress-activated protein kinases (JNK/SAPK) and p38 mitogen-activated protein kinase (MAPK) and also induces Cox-2 expression and prostaglandin E2 (PGE2) production. Dinoprostone 208-224 interleukin 1 beta Rattus norvegicus 28-36 9786861-2 1998 We reported previously that IL-1beta rapidly activates the c-Jun NH2-terminal/stress-activated protein kinases (JNK/SAPK) and p38 mitogen-activated protein kinase (MAPK) and also induces Cox-2 expression and prostaglandin E2 (PGE2) production. Dinoprostone 226-230 interleukin 1 beta Rattus norvegicus 28-36 9786861-3 1998 The current study demonstrates that overexpression of the dominant negative form of JNK1 or p54 JNK2/SAPKbeta reduces Cox-2 expression and PGE2 production stimulated by IL-1beta. Dinoprostone 139-143 interleukin 1 beta Rattus norvegicus 169-177 9786861-4 1998 Similarly, overexpression of the kinase-dead form of p38 MAPK also inhibits IL-1beta-induced Cox-2 expression and PGE2 production. Dinoprostone 114-118 interleukin 1 beta Rattus norvegicus 76-84 9786861-9 1998 This study suggests that the activation of both JNK/SAPK and p38 MAPK signaling cascades is required for IL-1beta-induced Cox-2 expression and PGE2 synthesis. Dinoprostone 143-147 interleukin 1 beta Rattus norvegicus 105-113 9794247-4 1998 Phenylmethylsulphonyl fluoride, lactacystin, and carbobenzoxyleucylleucylnorvaline also enhance prostacyclin production after incubation with interleukin-1beta and transforming growth factor-alpha. Phenylmethylsulfonyl Fluoride 0-30 interleukin 1 beta Rattus norvegicus 142-159 9751495-4 1998 N(G)-monomethyl-L-arginine inhibited the IL-1beta-induced increase in HO-1. omega-N-Methylarginine 0-26 interleukin 1 beta Rattus norvegicus 41-49 9794247-4 1998 Phenylmethylsulphonyl fluoride, lactacystin, and carbobenzoxyleucylleucylnorvaline also enhance prostacyclin production after incubation with interleukin-1beta and transforming growth factor-alpha. lactacystin 32-43 interleukin 1 beta Rattus norvegicus 142-159 9794247-4 1998 Phenylmethylsulphonyl fluoride, lactacystin, and carbobenzoxyleucylleucylnorvaline also enhance prostacyclin production after incubation with interleukin-1beta and transforming growth factor-alpha. carbobenzoxyleucylleucylnorvaline 49-82 interleukin 1 beta Rattus norvegicus 142-159 9794247-4 1998 Phenylmethylsulphonyl fluoride, lactacystin, and carbobenzoxyleucylleucylnorvaline also enhance prostacyclin production after incubation with interleukin-1beta and transforming growth factor-alpha. Epoprostenol 96-108 interleukin 1 beta Rattus norvegicus 142-159 9794247-6 1998 Cells, treated with phenylmethylsulphonyl fluoride, TPA, interleukin-1beta, lactacystin or the peptide aldehydes exhibit increased prostaglandin endoperoxide G/H synthase activity. Phenylmethylsulfonyl Fluoride 20-50 interleukin 1 beta Rattus norvegicus 57-74 9794247-6 1998 Cells, treated with phenylmethylsulphonyl fluoride, TPA, interleukin-1beta, lactacystin or the peptide aldehydes exhibit increased prostaglandin endoperoxide G/H synthase activity. Prostaglandin Endoperoxides 131-157 interleukin 1 beta Rattus norvegicus 57-74 9753298-0 1998 Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase. Nitric Oxide 135-147 interleukin 1 beta Rattus norvegicus 75-83 9753298-2 1998 Interleukin-6 (IL-6) alone or in combination with IL-1beta inhibits glucose-stimulated insulin release from isolated rat pancreatic islets by unknown mechanisms. Glucose 68-75 interleukin 1 beta Rattus norvegicus 50-58 9753298-4 1998 CNTF (20 ng/ml) potentiated IL-1beta-mediated (5-150 pg/ml) nitric oxide (NO) synthesis from neonatal Wistar rat islets by 31-116%, inhibition of accumulated insulin release by 34-49%, and inhibition insulin response to a 2-h glucose challenge by 31-36%. Nitric Oxide 60-72 interleukin 1 beta Rattus norvegicus 28-36 9753298-4 1998 CNTF (20 ng/ml) potentiated IL-1beta-mediated (5-150 pg/ml) nitric oxide (NO) synthesis from neonatal Wistar rat islets by 31-116%, inhibition of accumulated insulin release by 34-49%, and inhibition insulin response to a 2-h glucose challenge by 31-36%. Glucose 226-233 interleukin 1 beta Rattus norvegicus 28-36 9751495-7 1998 Cobalt chloride (CoCl2) protected islets from the inhibitory effects of IL-1beta on glucose-stimulated insulin release and glucose oxidation. cobaltous chloride 0-15 interleukin 1 beta Rattus norvegicus 72-80 9751495-7 1998 Cobalt chloride (CoCl2) protected islets from the inhibitory effects of IL-1beta on glucose-stimulated insulin release and glucose oxidation. cobaltous chloride 17-22 interleukin 1 beta Rattus norvegicus 72-80 9751495-7 1998 Cobalt chloride (CoCl2) protected islets from the inhibitory effects of IL-1beta on glucose-stimulated insulin release and glucose oxidation. Glucose 84-91 interleukin 1 beta Rattus norvegicus 72-80 9751495-9 1998 An inhibitor of HO-1 activity, zinc-protoporphyrin IX (ZnPP), prevented the protective effect of CoCl2 on insulin release with IL-1beta but did not affect HO-1 expression or the inhibitory response to IL-1beta alone. zinc protoporphyrin 31-53 interleukin 1 beta Rattus norvegicus 127-135 9751495-9 1998 An inhibitor of HO-1 activity, zinc-protoporphyrin IX (ZnPP), prevented the protective effect of CoCl2 on insulin release with IL-1beta but did not affect HO-1 expression or the inhibitory response to IL-1beta alone. zinc protoporphyrin 55-59 interleukin 1 beta Rattus norvegicus 127-135 9751495-9 1998 An inhibitor of HO-1 activity, zinc-protoporphyrin IX (ZnPP), prevented the protective effect of CoCl2 on insulin release with IL-1beta but did not affect HO-1 expression or the inhibitory response to IL-1beta alone. cobaltous chloride 97-102 interleukin 1 beta Rattus norvegicus 127-135 9751495-10 1998 ZnPP also inhibited the protective effect of hemin in IL-1beta-treated islets. zinc protoporphyrin 0-4 interleukin 1 beta Rattus norvegicus 54-62 9751495-10 1998 ZnPP also inhibited the protective effect of hemin in IL-1beta-treated islets. Hemin 45-50 interleukin 1 beta Rattus norvegicus 54-62 9751495-11 1998 CoCl2 inhibited the marked increase in islet nitrite production in response to IL-1beta. cobaltous chloride 0-5 interleukin 1 beta Rattus norvegicus 79-87 9751495-11 1998 CoCl2 inhibited the marked increase in islet nitrite production in response to IL-1beta. Nitrites 45-52 interleukin 1 beta Rattus norvegicus 79-87 9751495-12 1998 Cobalt-protoporphyrin IX (CoPP), which increased HO expression and activity, also protected islets from the inhibitory effects of IL-1beta, even though IL-1beta largely blocked the CoPP-induced increase in HO-1 expression. cobaltiprotoporphyrin 0-24 interleukin 1 beta Rattus norvegicus 130-138 9751495-12 1998 Cobalt-protoporphyrin IX (CoPP), which increased HO expression and activity, also protected islets from the inhibitory effects of IL-1beta, even though IL-1beta largely blocked the CoPP-induced increase in HO-1 expression. cobaltiprotoporphyrin 26-30 interleukin 1 beta Rattus norvegicus 130-138 9751495-12 1998 Cobalt-protoporphyrin IX (CoPP), which increased HO expression and activity, also protected islets from the inhibitory effects of IL-1beta, even though IL-1beta largely blocked the CoPP-induced increase in HO-1 expression. cobaltiprotoporphyrin 181-185 interleukin 1 beta Rattus norvegicus 152-160 9751495-15 1998 Thus, increased HO-1 expression and/or HO activity in response to CoCl2, CoPP, and hemin, seems to mediate protective responses of pancreatic islets against IL-1beta. cobaltiprotoporphyrin 73-77 interleukin 1 beta Rattus norvegicus 157-165 9766386-0 1998 Specificity of interleukin-1beta-induced changes in monoamine concentrations in hypothalamic nuclei: blockade by interleukin-1 receptor antagonist. monoamine 52-61 interleukin 1 beta Rattus norvegicus 15-32 9784426-5 1998 To rule out the possibility that DEX was inhibiting LPS-induced IL-6 release by blocking IL-6 gene expression, we tested the effect of DEX on interleukin 1beta(IL-1)-induced IL-6 release. Dexamethasone 135-138 interleukin 1 beta Rattus norvegicus 142-159 9755854-0 1998 Potentiation of nitric oxide synthase expression by superoxide in interleukin 1 beta-stimulated rat mesangial cells. Superoxides 52-62 interleukin 1 beta Rattus norvegicus 66-84 9755854-1 1998 Exposure of mesangial cells to superoxide, generated by the hypoxanthine/xanthine oxidase system or by the redox cycler 2,3-dimethoxy-1,4-naphthoquinone caused a concentration-dependent amplification of interleukin (IL)-1beta-stimulated nitrite production. Superoxides 31-41 interleukin 1 beta Rattus norvegicus 203-225 9755854-1 1998 Exposure of mesangial cells to superoxide, generated by the hypoxanthine/xanthine oxidase system or by the redox cycler 2,3-dimethoxy-1,4-naphthoquinone caused a concentration-dependent amplification of interleukin (IL)-1beta-stimulated nitrite production. 2,3-dimethoxy-1,4-naphthoquinone 120-152 interleukin 1 beta Rattus norvegicus 203-225 9755854-5 1998 In transient transfection studies, superoxide caused a 10-fold augmentation of iNOS promoter activity in IL-1beta-challenged mesangial cells. Superoxides 35-45 interleukin 1 beta Rattus norvegicus 105-113 9724308-1 1998 Proinflammatory cytokines (interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma; Cytomix) depress myocardial contractile work partially by stimulating expression of inducible nitric oxide (NO) synthase (iNOS). Nitric Oxide 191-203 interleukin 1 beta Rattus norvegicus 27-73 9697133-0 1998 Glutamate release in the nucleus tractus solitarius induced by peripheral lipopolysaccharide and interleukin-1 beta. Glutamic Acid 0-9 interleukin 1 beta Rattus norvegicus 97-115 9697133-2 1998 Glutamate was measured in the nucleus tractus solitarius, the brain area receiving glutamatergic vagal afferents, after peripheral injection of lipopolysaccharide or interleukin-1 beta. Glutamic Acid 0-9 interleukin 1 beta Rattus norvegicus 166-184 9697133-3 1998 Intraperitoneal or intravenous saline or intraperitoneal heat-inactivated interleukin-1 beta increased glutamate release, measured by brain microdialysis in freely-moving rats at 20 min (137 +/- 19%, 126 +/- 10% and 133 +/- 6%, respectively), without inducing any other change up to 3 h after injection. Glutamic Acid 103-112 interleukin 1 beta Rattus norvegicus 74-92 9697133-9 1998 Intraperitoneal interleukin-1 beta (4 micrograms/rat) increased glutamate release at 20 min (126 +/- 6%) and at 40 min (150 +/- 18%). Glutamic Acid 64-73 interleukin 1 beta Rattus norvegicus 16-34 9728078-0 1998 IL-1beta increases norepinephrine level in rat frontal cortex: involvement of prostanoids, NO, and glutamate. Norepinephrine 19-33 interleukin 1 beta Rattus norvegicus 0-8 9728078-0 1998 IL-1beta increases norepinephrine level in rat frontal cortex: involvement of prostanoids, NO, and glutamate. Prostaglandins 78-89 interleukin 1 beta Rattus norvegicus 0-8 9728078-0 1998 IL-1beta increases norepinephrine level in rat frontal cortex: involvement of prostanoids, NO, and glutamate. Glutamic Acid 99-108 interleukin 1 beta Rattus norvegicus 0-8 9728078-2 1998 A local injection of IL-1beta (3 and 10 ng) induced an elevation of norepinephrine (NE) concentration in the medial prefrontal cortex (mPFC). Norepinephrine 68-82 interleukin 1 beta Rattus norvegicus 21-29 9728078-6 1998 Furthermore, a microinjection of IL-1beta elevated the extracellular concentration of glutamate in the mPFC. Glutamic Acid 86-95 interleukin 1 beta Rattus norvegicus 33-41 9728078-7 1998 These findings suggest that the IL-1beta-induced rise in NE levels in the mPFC is caused by activation of the glutamatergic system and the glutamate-induced increases in prostanoids and NO. Glutamic Acid 110-119 interleukin 1 beta Rattus norvegicus 32-40 9728078-7 1998 These findings suggest that the IL-1beta-induced rise in NE levels in the mPFC is caused by activation of the glutamatergic system and the glutamate-induced increases in prostanoids and NO. Prostaglandins 170-181 interleukin 1 beta Rattus norvegicus 32-40 9766386-1 1998 The purpose of this study was to examine specificity in the effects of interleukin-1beta (IL-1beta) on monoamines in various areas of the hypothalamus. monoamines 103-113 interleukin 1 beta Rattus norvegicus 71-88 9766386-1 1998 The purpose of this study was to examine specificity in the effects of interleukin-1beta (IL-1beta) on monoamines in various areas of the hypothalamus. monoamines 103-113 interleukin 1 beta Rattus norvegicus 90-98 9727370-9 1998 However, dexamethasone significantly inhibited the increase in monocyte chemoattractant protein-1 mRNA seen after stimulation with interleukin 1beta, although this was not complete. Dexamethasone 9-22 interleukin 1 beta Rattus norvegicus 131-148 9831175-5 1998 Treatment with dexamethasone (DEX) prior to the administration of IL-1beta prevented the CS increase, diminished the CA increase and enhanced AChE activity in nerve fibers, and led to inhibition of the proliferative response of thymocytes to mitogen. Corticosterone 89-91 interleukin 1 beta Rattus norvegicus 66-74 9831177-6 1998 In vivo, recombinant rat IL-1alpha and IL-1beta enhanced body temperature, increased plasma levels of corticosterone and ACTH, and depressed social behaviour. Corticosterone 102-116 interleukin 1 beta Rattus norvegicus 39-47 9827358-10 1998 Intravenous injection of IL-1 beta produced high brain and serum PGE2 levels, which were also significantly suppressed by EA stimulation. Dinoprostone 65-69 interleukin 1 beta Rattus norvegicus 25-34 9698594-7 1998 Both types of asbestos fibers (chrysotile > crocidolite) upregulated the formation of NO2- in mesothelial cells costimulated with IL-1beta in a concentration-dependent and time-dependent fashion. Nitrogen Dioxide 89-92 interleukin 1 beta Rattus norvegicus 133-141 9745524-0 1998 Protective effect of TNF-alpha and IL-1 beta inhibitor FR167653 on ischemia-reperfusion injury in rat small intestinal transplantation. FR 167653 55-63 interleukin 1 beta Rattus norvegicus 35-44 9685387-3 1998 Treatment of rat primary astrocytes with tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta led to marked alteration in cellular redox (decrease in intracellular GSH) and rapid degradation of SM to ceramide. Glutathione 172-175 interleukin 1 beta Rattus norvegicus 84-101 9685387-3 1998 Treatment of rat primary astrocytes with tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta led to marked alteration in cellular redox (decrease in intracellular GSH) and rapid degradation of SM to ceramide. Sphingomyelins 202-204 interleukin 1 beta Rattus norvegicus 84-101 9685387-3 1998 Treatment of rat primary astrocytes with tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta led to marked alteration in cellular redox (decrease in intracellular GSH) and rapid degradation of SM to ceramide. Ceramides 208-216 interleukin 1 beta Rattus norvegicus 84-101 9725362-6 1998 RESULTS: Continuous nitric oxide release by S-nitoso-N-acetyl-D, L-penicillamine decreased lung macrophage tumor necrosis factor-alpha and interleukin-1beta production in a dose-dependent fashion (6 rats per group; data were analyzed for significance [p < 0.05] using two-way analysis of variance with Tukey"s post-hoc correction). Nitric Oxide 20-32 interleukin 1 beta Rattus norvegicus 139-156 9776568-2 1998 The purpose of this study was to determine the effects of carbon tetrachloride administration on tumor necrosis factor-alpha (TNF-alpha) and interleukin 1beta (IL-1beta) concentrations in serum and liver of rats. Carbon Tetrachloride 58-78 interleukin 1 beta Rattus norvegicus 141-158 9776568-2 1998 The purpose of this study was to determine the effects of carbon tetrachloride administration on tumor necrosis factor-alpha (TNF-alpha) and interleukin 1beta (IL-1beta) concentrations in serum and liver of rats. Carbon Tetrachloride 58-78 interleukin 1 beta Rattus norvegicus 160-168 9698594-9 1998 Both types of asbestos fibers also induced iNOS protein expression and the formation of nitrotyrosine in mesothelial cells and greatly induced the formation of nitrate (NO3-), a surrogate marker of ONOO- formation, in IL-1beta-stimulated cells. Nitrates 160-167 interleukin 1 beta Rattus norvegicus 218-226 9725362-6 1998 RESULTS: Continuous nitric oxide release by S-nitoso-N-acetyl-D, L-penicillamine decreased lung macrophage tumor necrosis factor-alpha and interleukin-1beta production in a dose-dependent fashion (6 rats per group; data were analyzed for significance [p < 0.05] using two-way analysis of variance with Tukey"s post-hoc correction). s-nitoso-n-acetyl-d, l-penicillamine 44-80 interleukin 1 beta Rattus norvegicus 139-156 9698594-9 1998 Both types of asbestos fibers also induced iNOS protein expression and the formation of nitrotyrosine in mesothelial cells and greatly induced the formation of nitrate (NO3-), a surrogate marker of ONOO- formation, in IL-1beta-stimulated cells. punky blue 169-173 interleukin 1 beta Rattus norvegicus 218-226 9756389-6 1998 Chondrocytes and patellae, as well as femoral head caps, responded concentration-dependently to IL-1beta challenge (0 to 250 U ml(-1) and 0 to 15 U ml(-1) respectively) by a large increase in nitrite level and a marked suppression of proteoglycan synthesis. Nitrites 192-199 interleukin 1 beta Rattus norvegicus 96-104 9756389-7 1998 Above these concentrations of IL-1beta (2500 U ml(-1) and 30 U ml(-1) respectively), proteoglycan synthesis plateaued whereas nitrite release still increased thus suggesting different concentration-response curves. Nitrites 126-133 interleukin 1 beta Rattus norvegicus 30-38 9724140-8 1998 Several endogenous secretagogues (substance P, 5-hydroxytryptamine, interleukin-1beta), which are important mediators of the inflammatory bowel diseases, act, at least in part, through the liberation of nitric oxide. Nitric Oxide 203-215 interleukin 1 beta Rattus norvegicus 68-85 9805781-2 1998 The changes were the most obvious within 15 and 120 min following the IL-1 beta administration: elevation of the 11-OSC, increase in the CA content, and decrease in the AChE activity in thymic nerve fibres. 11-osc 113-119 interleukin 1 beta Rattus norvegicus 70-79 9696008-0 1998 The inhibitory effect of interleukin 1beta on rat hepatocyte DNA synthesis is mediated by nitric oxide. Nitric Oxide 90-102 interleukin 1 beta Rattus norvegicus 25-42 9696008-4 1998 The inhibition of DNA synthesis by IL-1beta was completely abrogated when NO production was inhibited by N-monomethyl-L-arginine (NMA), a competitive inhibitor of iNOS. omega-N-Methylarginine 105-128 interleukin 1 beta Rattus norvegicus 35-43 9696008-4 1998 The inhibition of DNA synthesis by IL-1beta was completely abrogated when NO production was inhibited by N-monomethyl-L-arginine (NMA), a competitive inhibitor of iNOS. omega-N-Methylarginine 130-133 interleukin 1 beta Rattus norvegicus 35-43 9696008-6 1998 We also found that hepatocyte DNA synthesis inhibition by IL-1beta was completely antagonized by providing deoxynucleosides to bypass the block in ribonucleotide reductase, a rate-limiting step in DNA synthesis, thus implicating this enzyme in the mechanism of growth inhibition by IL-1beta. deoxynucleosides 107-123 interleukin 1 beta Rattus norvegicus 58-66 9696008-6 1998 We also found that hepatocyte DNA synthesis inhibition by IL-1beta was completely antagonized by providing deoxynucleosides to bypass the block in ribonucleotide reductase, a rate-limiting step in DNA synthesis, thus implicating this enzyme in the mechanism of growth inhibition by IL-1beta. deoxynucleosides 107-123 interleukin 1 beta Rattus norvegicus 282-290 9655743-7 1998 05 versus exposure to normoxia and treatment with saline) in lung XDH/XO activity and mRNA, the combination of LPS + IL-1beta and hypoxia caused a 4- and 3.5-fold increase in these values, respectively. Sodium Chloride 50-56 interleukin 1 beta Rattus norvegicus 117-125 9645713-5 1998 IL-1beta inhibits the hypothalamo-pituitary-gonadal (HPG) axis by suppressing GnRH and gonadal steroid production. Steroids 95-102 interleukin 1 beta Rattus norvegicus 0-8 9614146-0 1998 Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases. Nitric Oxide 47-59 interleukin 1 beta Rattus norvegicus 0-17 9614146-1 1998 Interleukin-1beta (IL-1beta) is cytotoxic to rat pancreatic beta-cells by inhibiting glucose oxidation, causing DNA damage and inducing apoptosis. Glucose 85-92 interleukin 1 beta Rattus norvegicus 0-17 9614146-1 1998 Interleukin-1beta (IL-1beta) is cytotoxic to rat pancreatic beta-cells by inhibiting glucose oxidation, causing DNA damage and inducing apoptosis. Glucose 85-92 interleukin 1 beta Rattus norvegicus 19-27 9614146-7 1998 Inhibition of p38 but not of ERK1/2 attenuated IL-1beta-mediated inhibition of glucose-stimulated insulin release. Glucose 79-86 interleukin 1 beta Rattus norvegicus 47-55 9672378-0 1998 Linomide-mediated protection of oligodendrocytes is associated with inhibition of nitric oxide production and IL-1beta expression in Lewis rat glial cells. roquinimex 0-8 interleukin 1 beta Rattus norvegicus 110-118 21781874-4 1998 The mRNA expression of a number of other inflammatory mediators such as interleukin-1beta, interleukin-6, tumor necrosis factor-alpha and cyclooxygenase-2 was also increased by the exposure to beta-glucan. beta-Glucans 193-204 interleukin 1 beta Rattus norvegicus 72-89 9603200-0 1998 Prostaglandin E2 and 4-aminopyridine prevent the lipopolysaccharide-induced outwardly rectifying potassium current and interleukin-1beta production in cultured rat microglia. 4-Aminopyridine 21-36 interleukin 1 beta Rattus norvegicus 119-136 9688345-0 1998 Effect of endotoxin and interleukin-1beta on corticotropin-releasing-factor and prostaglandin release by rat brainstem slices. Prostaglandins 80-93 interleukin 1 beta Rattus norvegicus 24-41 9688345-1 1998 This study investigated the effects of lipopolysaccharide (LPS) and interleukin-1beta (IL-1beta) on corticotropin releasing factor (CRF) and prostaglandin E2 (PGE2) release by brainstem slices in vitro. Dinoprostone 141-157 interleukin 1 beta Rattus norvegicus 87-95 9688345-3 1998 The direct stimulation of brainstem slices with IL-1beta (3-25 pM) did not modify basal or potassium-stimulated CRF release, although IL-1beta at the dose of 25 pM increased PGE2 production. Dinoprostone 174-178 interleukin 1 beta Rattus norvegicus 134-142 9688345-5 1998 of LPS (1-10 microg/kg) or IL-1beta (1-10 microg/kg) evoked a dose-related potentiation of the ex-vivo release of CRF and PGE2 from brainstem slices. Dinoprostone 122-126 interleukin 1 beta Rattus norvegicus 27-35 9688345-8 1998 The results of the present study provide evidence that peripheral, rather than central, endotoxin and IL-1beta administration induce the activation of brainstem CRF and PGE2, supporting the hypothesis that peripheral cytokine signalling to the CNS is mediated by stimulation of peripheral afferents. Dinoprostone 169-173 interleukin 1 beta Rattus norvegicus 102-110 9579794-7 1998 These results demonstrate that in some, but not all, respects interleukin-1beta administration produced "stress like" effects on behaviour, monoamine neurotransmitters, hypothalamic pituitary adrenal axis activity and immune function, while the other cytokines produced less consistent effects on these parameters. monoamine 140-149 interleukin 1 beta Rattus norvegicus 62-79 9603200-8 1998 Prostaglandin E2 and 4-aminopyridine (a blocker of outward potassium currents) also significantly reduced interleukin-1beta production. 4-Aminopyridine 21-36 interleukin 1 beta Rattus norvegicus 106-123 9603200-8 1998 Prostaglandin E2 and 4-aminopyridine (a blocker of outward potassium currents) also significantly reduced interleukin-1beta production. Potassium 59-68 interleukin 1 beta Rattus norvegicus 106-123 9633998-6 1998 In comparison, expression of mRNA for COX-2 stimulated by IL-1beta was inhibited by actinomycin D, but not by cycloheximide. Dactinomycin 84-97 interleukin 1 beta Rattus norvegicus 58-66 9575163-2 1998 In this study, we considered whether the trigger for this age-related decrease in arachidonic acid might be increased lipid peroxidation stimulated by the proinflammatory cytokine, interleukin-1beta. Arachidonic Acid 82-98 interleukin 1 beta Rattus norvegicus 181-198 9565611-2 1998 Incubation of cardiac myocytes for 24 h with 4 ng/ml interleukin-1beta and 100 units/ml interferon-gamma stimulated an increase in nitric oxide production, inducible nitric-oxide synthase (iNOS) mRNA, and iNOS protein. Nitric Oxide 131-143 interleukin 1 beta Rattus norvegicus 53-70 9629255-9 1998 This analgesia, as well as the intraPOA IL-1 beta-induced hyperalgesia, was completely blocked by IL-1Ra or Na salicylate. na salicylate 108-121 interleukin 1 beta Rattus norvegicus 40-49 10076538-2 1998 Interleukin-1 beta (IL-1 beta) inhibited glucose-stimulated insulin release in cultured islets, but the presence of EA, EA-A, and to a lesser extent EA-S, preserved the secretory response. Glucose 41-48 interleukin 1 beta Rattus norvegicus 0-18 9603242-0 1998 Interleukin-1beta inhibits steroidogenic bioactivity in cultured rat ovarian granulosa cells by stimulation of progesterone degradation and inhibition of estrogen formation. Progesterone 111-123 interleukin 1 beta Rattus norvegicus 0-17 9603242-4 1998 Pulse labeling of cells with [3H]pregnenolone revealed IL-1beta to effect a decrease in the FSH-supported accumulation of [3H]progesterone while enhancing the accumulation of its proximal metabolite, [3H]20alpha-dihydroprogesterone. Tritium 30-33 interleukin 1 beta Rattus norvegicus 55-63 9603242-4 1998 Pulse labeling of cells with [3H]pregnenolone revealed IL-1beta to effect a decrease in the FSH-supported accumulation of [3H]progesterone while enhancing the accumulation of its proximal metabolite, [3H]20alpha-dihydroprogesterone. Pregnenolone 33-45 interleukin 1 beta Rattus norvegicus 55-63 9603242-4 1998 Pulse labeling of cells with [3H]pregnenolone revealed IL-1beta to effect a decrease in the FSH-supported accumulation of [3H]progesterone while enhancing the accumulation of its proximal metabolite, [3H]20alpha-dihydroprogesterone. [3h]progesterone 122-138 interleukin 1 beta Rattus norvegicus 55-63 9603242-4 1998 Pulse labeling of cells with [3H]pregnenolone revealed IL-1beta to effect a decrease in the FSH-supported accumulation of [3H]progesterone while enhancing the accumulation of its proximal metabolite, [3H]20alpha-dihydroprogesterone. [3h]20alpha-dihydroprogesterone 200-231 interleukin 1 beta Rattus norvegicus 55-63 9603262-8 1998 This study demonstrates that IL-6 does not play a role in regulating ovulation induced by LH in vitro but is capable of reducing LH/IL-1beta-enhanced ovulation rates. Luteinizing Hormone 129-131 interleukin 1 beta Rattus norvegicus 132-140 10076538-12 1998 Thus, EA and DHEA and their acetate congeners protected the beta-cell from the inhibitory effects of IL-1 beta, and inhibited glucose transport and oxidation, and inducible nitricoxide synthase expression. Dehydroepiandrosterone 13-17 interleukin 1 beta Rattus norvegicus 101-110 10076538-12 1998 Thus, EA and DHEA and their acetate congeners protected the beta-cell from the inhibitory effects of IL-1 beta, and inhibited glucose transport and oxidation, and inducible nitricoxide synthase expression. Acetates 28-35 interleukin 1 beta Rattus norvegicus 101-110 10076538-2 1998 Interleukin-1 beta (IL-1 beta) inhibited glucose-stimulated insulin release in cultured islets, but the presence of EA, EA-A, and to a lesser extent EA-S, preserved the secretory response. Glucose 41-48 interleukin 1 beta Rattus norvegicus 20-29 10076538-3 1998 IL-1 beta also increased islet nitrite production, which was antagonized by EA and EA-A, but not by EA-S. Nitrites 31-38 interleukin 1 beta Rattus norvegicus 0-9 10076538-3 1998 IL-1 beta also increased islet nitrite production, which was antagonized by EA and EA-A, but not by EA-S. Androsterone 76-78 interleukin 1 beta Rattus norvegicus 0-9 10076538-3 1998 IL-1 beta also increased islet nitrite production, which was antagonized by EA and EA-A, but not by EA-S. ea-a 83-87 interleukin 1 beta Rattus norvegicus 0-9 9590244-7 1998 Using probes containing C/EBP-binding sites from the iNOS gene revealed further binding of different complexes, all of which were strongly inducible by cAMP and to a lower extent also by IL-1beta. Cyclic AMP 152-156 interleukin 1 beta Rattus norvegicus 187-195 10076538-7 1998 EA, EA-A, DHEA, and DHEA-A, but not the sulfate conjugates, also inhibited RINm5F cell IL-1 beta-induced nitric oxide synthase (iNOS) activity. Androsterone 0-2 interleukin 1 beta Rattus norvegicus 87-96 9590244-8 1998 Abs against cyclic AMP-responsive element-binding protein, C/EBPbeta, and C/EBPdelta were able to partially supershift single complexes, suggesting the participation of these transcription factors in the regulation of iNOS gene expression by cAMP and IL-1beta. Cyclic AMP 12-22 interleukin 1 beta Rattus norvegicus 251-259 10076538-7 1998 EA, EA-A, DHEA, and DHEA-A, but not the sulfate conjugates, also inhibited RINm5F cell IL-1 beta-induced nitric oxide synthase (iNOS) activity. ea-a 4-8 interleukin 1 beta Rattus norvegicus 87-96 9590244-8 1998 Abs against cyclic AMP-responsive element-binding protein, C/EBPbeta, and C/EBPdelta were able to partially supershift single complexes, suggesting the participation of these transcription factors in the regulation of iNOS gene expression by cAMP and IL-1beta. Cyclic AMP 242-246 interleukin 1 beta Rattus norvegicus 251-259 10076538-7 1998 EA, EA-A, DHEA, and DHEA-A, but not the sulfate conjugates, also inhibited RINm5F cell IL-1 beta-induced nitric oxide synthase (iNOS) activity. Dehydroepiandrosterone 10-14 interleukin 1 beta Rattus norvegicus 87-96 10076538-7 1998 EA, EA-A, DHEA, and DHEA-A, but not the sulfate conjugates, also inhibited RINm5F cell IL-1 beta-induced nitric oxide synthase (iNOS) activity. dhea-a 20-26 interleukin 1 beta Rattus norvegicus 87-96 10076538-9 1998 EA inhibited RINm5F cell Cu/Zn-SOD in the presence and absence of IL-1 beta, whereas EA-S increased basal enzyme activity and did not affect the IL-1 beta response. Androsterone 0-2 interleukin 1 beta Rattus norvegicus 66-75 10076538-10 1998 EA did not affect basal Mn-SOD activity and inhibited IL-1 beta-stimulated activity, whereas EA-S was without effect. Androsterone 0-2 interleukin 1 beta Rattus norvegicus 54-63 10076538-12 1998 Thus, EA and DHEA and their acetate congeners protected the beta-cell from the inhibitory effects of IL-1 beta, and inhibited glucose transport and oxidation, and inducible nitricoxide synthase expression. Androsterone 6-8 interleukin 1 beta Rattus norvegicus 101-110 9620452-2 1998 This is in agreement with the effects of TGF-beta1 and IL-1beta on beating rate and calcium uptake, suggesting that such effects might be mediated, at least partially, through up-regulation of the Na+/Ca2+ exchanger. Calcium 84-91 interleukin 1 beta Rattus norvegicus 55-63 9619376-1 1998 A number of previous studies have concluded that prostaglandins (PGs) play a crucial role in mediating the corticotropin-releasing hormone and adrenocorticotropin (ACTH) secretion induced by interleukin (IL) 1 beta in the rat. Prostaglandins 49-63 interleukin 1 beta Rattus norvegicus 191-214 9564864-6 1998 Treatment of cultured whole ovarian dispersates with IL-1beta resulted in dose- and time-dependent up-regulation of PGS-2 transcripts (as well as of immunoreactive PGS-2 protein and PGE2 accumulation), characterized by an ED50 of 2 ng/ml and a maximal (72-fold) increase at 10 ng/ml. Dinoprostone 182-186 interleukin 1 beta Rattus norvegicus 53-61 9619376-1 1998 A number of previous studies have concluded that prostaglandins (PGs) play a crucial role in mediating the corticotropin-releasing hormone and adrenocorticotropin (ACTH) secretion induced by interleukin (IL) 1 beta in the rat. Prostaglandins 65-68 interleukin 1 beta Rattus norvegicus 191-214 9619376-5 1998 Although IL-1 beta-induced ACTH response was significantly suppressed by indomethacin given either 10 or 20 min before, the latter protocol led to a significantly greater inhibition of the hormonal response than the former. Indomethacin 73-85 interleukin 1 beta Rattus norvegicus 9-18 9610742-0 1998 Alendronate/interleukin-1beta cotreatment increases interleukin-6 in bone and UMR-106 cells: dose dependence and relationship to the antiresorptive effect of alendronate. Alendronate 158-169 interleukin 1 beta Rattus norvegicus 12-29 9581683-0 1998 Interleukin 1beta and interleukin 6, but not tumor necrosis factor alpha, inhibit insulin-stimulated glycogen synthesis in rat hepatocytes. Glycogen 101-109 interleukin 1 beta Rattus norvegicus 0-35 9581683-4 1998 Interleukin 1beta (IL-1beta) and interleukin 6 (IL-6) markedly inhibited the increase of glycogen deposition stimulated by insulin in primary rat hepatocyte cultures; however, tumor necrosis factor alpha had no effect. Glycogen 89-97 interleukin 1 beta Rattus norvegicus 0-17 9581683-4 1998 Interleukin 1beta (IL-1beta) and interleukin 6 (IL-6) markedly inhibited the increase of glycogen deposition stimulated by insulin in primary rat hepatocyte cultures; however, tumor necrosis factor alpha had no effect. Glycogen 89-97 interleukin 1 beta Rattus norvegicus 19-27 9581683-7 1998 In experiments with kinase inhibitors, serine/threonine kinase inhibitor K252a blocked IL-1beta- and IL-6-induced inhibitions of glycogen deposition, as well as glycogen synthase activity, whereas another kinase inhibitor staurosporine blocked only IL-6-induced inhibition. Glycogen 129-137 interleukin 1 beta Rattus norvegicus 87-95 9581683-8 1998 Tyrosine kinase inhibitor herbimycin A blocked only IL-1beta-induced inhibition. herbimycin 26-38 interleukin 1 beta Rattus norvegicus 52-60 9581683-9 1998 These results indicate that IL-1beta and IL-6 regulate insulin-stimulated glycogen synthesis through different pathways involving protein phosphorylation in hepatocytes. Glycogen 74-82 interleukin 1 beta Rattus norvegicus 28-36 9581684-6 1998 Chronic ethanol treatment significantly increased the expression of CYP2E1, microsomal p-nitrophenol hydroxylase activity (indicative for CYP2E1 enzyme activity), and the expression of transforming growth factor beta1 (TGF-beta1), tumor necrosis factor alpha (TNF-alpha), and interleukin (IL)-1beta (1.4- to 4.6-fold). Ethanol 8-15 interleukin 1 beta Rattus norvegicus 276-298 9576743-4 1998 Further, overexpression of MnSOD in either RIN- or INS-1-derived lines results in a sharp reduction in IL-1beta-induced nitric oxide (NO) production, a finding that correlates with reduced levels of the inducible form of nitric oxide synthase (iNOS). Nitric Oxide 120-132 interleukin 1 beta Rattus norvegicus 103-111 9610742-7 1998 Alendronate (70 microM) inhibited the IL-1beta-stimulated resorption. Alendronate 0-11 interleukin 1 beta Rattus norvegicus 38-46 9576743-5 1998 Treatment of INS-1 cells with L-NMMA, an inhibitor of iNOS, provides the same degree of protection against IL-1beta or supernatants from LPS-activated rat PBMC as MnSOD overexpression, supporting the idea that MnSOD protects INS-1 cells by interfering with the normal IL-1beta-mediated increase in iNOS. omega-N-Methylarginine 30-36 interleukin 1 beta Rattus norvegicus 107-115 9610742-10 1998 Indomethacin (1 mM) inhibited the IL-6 increase elicited by 180 pM IL-1beta and the enhanced IL-6 production elicited by cotreatment with IL-1beta and alendronate. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 67-75 9576743-5 1998 Treatment of INS-1 cells with L-NMMA, an inhibitor of iNOS, provides the same degree of protection against IL-1beta or supernatants from LPS-activated rat PBMC as MnSOD overexpression, supporting the idea that MnSOD protects INS-1 cells by interfering with the normal IL-1beta-mediated increase in iNOS. omega-N-Methylarginine 30-36 interleukin 1 beta Rattus norvegicus 268-276 9610742-10 1998 Indomethacin (1 mM) inhibited the IL-6 increase elicited by 180 pM IL-1beta and the enhanced IL-6 production elicited by cotreatment with IL-1beta and alendronate. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 138-146 9610742-11 1998 Since bone cultures contain multiple cell types, further experiments were carried out to determine whether alendronate could increase IL-1beta-stimulated IL-6 production in an osteoblast cell line, UMR-106. Alendronate 107-118 interleukin 1 beta Rattus norvegicus 134-142 9610742-14 1998 The results from the bone organ cultures show that alendronate can enhance IL-6 production elicited by higher concentrations of the cytokine IL-1beta in bone, but that this effect on IL-6 does not prevent the inhibitory actions of alendronate on bone resorption. Alendronate 51-62 interleukin 1 beta Rattus norvegicus 141-149 9618238-5 1998 Similarly, SNAC or SNAP dose-dependently decreased CK activity in intact ARVM, which was further attenuated by increasing the metabolic activity of the cells with electrical pacing for 1 h. Co-cultures of ARVM with interleukin 1 beta (IL-1 beta)- and interferon gamma (IFN gamma)-pretreated cardiac microvascular endothelial cells (CMEC) caused no detectable decline in myocyte CK activity. S-nitroso-N-acetylcysteine 11-15 interleukin 1 beta Rattus norvegicus 215-233 9610777-5 1998 Because astrocytes and microglia in demyelinating lesions of X-ALD brain express proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), we examined the effect of cAMP derivatives or rolipram on lipopolysaccharide-stimulated rat primary astrocytes and microglia and found that cAMP derivatives and rolipram inhibited the induction of TNF-alpha and IL-1beta in both astrocytes and microglia. Cyclic AMP 215-219 interleukin 1 beta Rattus norvegicus 178-186 9610777-5 1998 Because astrocytes and microglia in demyelinating lesions of X-ALD brain express proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), we examined the effect of cAMP derivatives or rolipram on lipopolysaccharide-stimulated rat primary astrocytes and microglia and found that cAMP derivatives and rolipram inhibited the induction of TNF-alpha and IL-1beta in both astrocytes and microglia. Rolipram 235-243 interleukin 1 beta Rattus norvegicus 178-186 9618238-5 1998 Similarly, SNAC or SNAP dose-dependently decreased CK activity in intact ARVM, which was further attenuated by increasing the metabolic activity of the cells with electrical pacing for 1 h. Co-cultures of ARVM with interleukin 1 beta (IL-1 beta)- and interferon gamma (IFN gamma)-pretreated cardiac microvascular endothelial cells (CMEC) caused no detectable decline in myocyte CK activity. S-nitroso-N-acetylcysteine 11-15 interleukin 1 beta Rattus norvegicus 235-244 9610777-5 1998 Because astrocytes and microglia in demyelinating lesions of X-ALD brain express proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), we examined the effect of cAMP derivatives or rolipram on lipopolysaccharide-stimulated rat primary astrocytes and microglia and found that cAMP derivatives and rolipram inhibited the induction of TNF-alpha and IL-1beta in both astrocytes and microglia. Cyclic AMP 329-333 interleukin 1 beta Rattus norvegicus 178-186 9610777-5 1998 Because astrocytes and microglia in demyelinating lesions of X-ALD brain express proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), we examined the effect of cAMP derivatives or rolipram on lipopolysaccharide-stimulated rat primary astrocytes and microglia and found that cAMP derivatives and rolipram inhibited the induction of TNF-alpha and IL-1beta in both astrocytes and microglia. Rolipram 350-358 interleukin 1 beta Rattus norvegicus 178-186 9730687-5 1998 In contrast, blockade of prostaglandin formation prevents both the stimulatory effect of IL-1beta on ACTH release, and its potentiation by L-NAME. Prostaglandins 25-38 interleukin 1 beta Rattus norvegicus 89-97 9663649-1 1998 Nitric oxide (NO) is an unstable gas that participates in the response of the hypothalamic-pituitary-adrenal (HPA) axis to a variety of immune signals, including turpentine-induced tissue damage and the systemic injection of the pro-inflammatory cytokine interleukin 1-beta (IL-1beta). Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 255-273 9663649-1 1998 Nitric oxide (NO) is an unstable gas that participates in the response of the hypothalamic-pituitary-adrenal (HPA) axis to a variety of immune signals, including turpentine-induced tissue damage and the systemic injection of the pro-inflammatory cytokine interleukin 1-beta (IL-1beta). Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 275-283 9663649-9 1998 IL-1beta-induced ACTH response to various doses of systematically injected L-NAME (1-100 mg/kg). NG-Nitroarginine Methyl Ester 75-81 interleukin 1 beta Rattus norvegicus 0-8 9663649-10 1998 At 10-100, but not 1 mg/kg, L-NAME significantly (P<0.01) augmented the ACTH response to IL-1beta, with a maximum effect observed at 30 and 100 mg/kg. NG-Nitroarginine Methyl Ester 28-34 interleukin 1 beta Rattus norvegicus 92-100 9602105-0 1998 Abdominal vagotomy attenuates interleukin-1 beta-induced nitric oxide release in the paraventricular nucleus region in conscious rats. Nitric Oxide 57-69 interleukin 1 beta Rattus norvegicus 30-48 9622204-1 1998 In this study, we have compared the time-course effects of lipopolysaccharide (LPS) and interleukin-1beta on prostaglandin (PG) production by primary cultures of rat astrocytes. Prostaglandins 109-122 interleukin 1 beta Rattus norvegicus 88-105 9622204-1 1998 In this study, we have compared the time-course effects of lipopolysaccharide (LPS) and interleukin-1beta on prostaglandin (PG) production by primary cultures of rat astrocytes. Prostaglandins 124-126 interleukin 1 beta Rattus norvegicus 88-105 9602105-1 1998 Nitric oxide (NO) has recently been shown to modulate the hypothalamic-pituitary-adrenal axis response to interleukin-1 beta (IL-1 beta). Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 106-124 9602105-1 1998 Nitric oxide (NO) has recently been shown to modulate the hypothalamic-pituitary-adrenal axis response to interleukin-1 beta (IL-1 beta). Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 126-135 9602105-3 1998 Intraperitoneally administered IL-1 beta produced a significant increase in both NO2- and NO3- levels in the PVN region. Nitrogen Dioxide 81-84 interleukin 1 beta Rattus norvegicus 31-40 9602105-3 1998 Intraperitoneally administered IL-1 beta produced a significant increase in both NO2- and NO3- levels in the PVN region. punky blue 90-93 interleukin 1 beta Rattus norvegicus 31-40 9683921-3 1998 RESULTS: Incubation of the cultures with interleukin-1 beta (IL-1 beta; 10 ng/ml) and tumor necrosis factor alpha (TNF alpha; 10 ng/ml) caused a marked increase in nitrite production. Nitrites 164-171 interleukin 1 beta Rattus norvegicus 41-59 9683921-3 1998 RESULTS: Incubation of the cultures with interleukin-1 beta (IL-1 beta; 10 ng/ml) and tumor necrosis factor alpha (TNF alpha; 10 ng/ml) caused a marked increase in nitrite production. Nitrites 164-171 interleukin 1 beta Rattus norvegicus 61-70 9568691-0 1998 Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. Nitric Oxide 90-102 interleukin 1 beta Rattus norvegicus 73-81 9568691-0 1998 Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. Prostaglandins 107-120 interleukin 1 beta Rattus norvegicus 73-81 9568691-2 1998 IL-1beta inhibits insulin secretion from pancreatic beta-cells by stimulating the expression of inducible nitric oxide synthase (iNOS) that generates the free radical nitric oxide. Nitric Oxide 106-118 interleukin 1 beta Rattus norvegicus 0-8 9568691-3 1998 IL-1beta also induces the coexpression of the inducible isoform of cyclooxygenase (COX-2) that results in the overproduction of proinflammatory prostaglandins. Prostaglandins 144-158 interleukin 1 beta Rattus norvegicus 0-8 9587701-13 1998 Peripheral injections of IL-1 beta dose-dependently induced fever and anorexia in rats, probably via induction of PGE2 in the brain or in peripheral tissues thereafter passing the blood-brain barrier. Dinoprostone 114-118 interleukin 1 beta Rattus norvegicus 25-34 9568691-6 1998 A serine protease inhibitor, Nalpha-P-tosyl-L-lysine chloromethyl ketone (TLCK), and a proteasome complex (26S) inhibitor, MG 132, inhibited IL-1beta-induced nitrite formation, an oxidation product of nitric oxide produced by iNOS, in a concentration-dependent manner, with complete inhibition observed at 100 micromol/l and 10 micromol/l, respectively. nalpha-p-tosyl-l-lysine chloromethyl ketone 29-72 interleukin 1 beta Rattus norvegicus 141-149 9587701-14 1998 Nitric oxide produced by cNOS seems to be a molecular mediator of IL-1 beta induced fever but not of anorexia. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 66-75 9568691-6 1998 A serine protease inhibitor, Nalpha-P-tosyl-L-lysine chloromethyl ketone (TLCK), and a proteasome complex (26S) inhibitor, MG 132, inhibited IL-1beta-induced nitrite formation, an oxidation product of nitric oxide produced by iNOS, in a concentration-dependent manner, with complete inhibition observed at 100 micromol/l and 10 micromol/l, respectively. Nitrites 158-165 interleukin 1 beta Rattus norvegicus 141-149 9568691-6 1998 A serine protease inhibitor, Nalpha-P-tosyl-L-lysine chloromethyl ketone (TLCK), and a proteasome complex (26S) inhibitor, MG 132, inhibited IL-1beta-induced nitrite formation, an oxidation product of nitric oxide produced by iNOS, in a concentration-dependent manner, with complete inhibition observed at 100 micromol/l and 10 micromol/l, respectively. Nitric Oxide 201-213 interleukin 1 beta Rattus norvegicus 141-149 9528932-7 1998 The suppressive action of IL-1beta (0.1 ng/ml) occurred predominantly in glucose-activated beta cells, reducing their high rates of insulin synthesis and release by more than 80%. Glucose 73-80 interleukin 1 beta Rattus norvegicus 26-34 9568691-8 1998 In an analogous manner, TLCK (100 micromol/l) and MG 132 (10 micromol/l) inhibited IL-1beta-induced COX-2 enzyme activity (PGE2 formation) and COX-2 gene expression at the level of mRNA and protein. Dinoprostone 123-127 interleukin 1 beta Rattus norvegicus 83-91 9528932-10 1998 The IL-1beta-stimulated expression of inducible nitric oxide synthase (iNOS) and heat shock protein 70 was more marked in the glucose-responsive subpopulation; that of heme oxygenase and Mn superoxide dismutase was comparable in the two subpopulations. Glucose 126-133 interleukin 1 beta Rattus norvegicus 4-12 9535019-3 1998 In order to study the possible modulation of interleukin-1beta (IL-1beta)-induced expression of inducible nitric oxide synthase (iNOS) by endogenously synthesized glycosphingolipids, we investigated rat aortic vascular smooth muscle cells (VSMC) grown in the presence of the inhibitor of glycosphingolipid synthesis, threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP). RV 538 317-371 interleukin 1 beta Rattus norvegicus 64-72 9528932-11 1998 Exposure to IL-1beta resulted in 10-fold higher medium nitrite levels in both subpopulations; this effect was prevented by the iNOS blocker, N(G)-methyl-L-arginine, which also prevented the IL-1beta-induced suppression in the glucose-responsive subpopulation. Nitrites 55-62 interleukin 1 beta Rattus norvegicus 12-20 9528932-11 1998 Exposure to IL-1beta resulted in 10-fold higher medium nitrite levels in both subpopulations; this effect was prevented by the iNOS blocker, N(G)-methyl-L-arginine, which also prevented the IL-1beta-induced suppression in the glucose-responsive subpopulation. Nitroarginine 141-163 interleukin 1 beta Rattus norvegicus 12-20 9528932-11 1998 Exposure to IL-1beta resulted in 10-fold higher medium nitrite levels in both subpopulations; this effect was prevented by the iNOS blocker, N(G)-methyl-L-arginine, which also prevented the IL-1beta-induced suppression in the glucose-responsive subpopulation. Nitroarginine 141-163 interleukin 1 beta Rattus norvegicus 190-198 9528932-11 1998 Exposure to IL-1beta resulted in 10-fold higher medium nitrite levels in both subpopulations; this effect was prevented by the iNOS blocker, N(G)-methyl-L-arginine, which also prevented the IL-1beta-induced suppression in the glucose-responsive subpopulation. Glucose 226-233 interleukin 1 beta Rattus norvegicus 12-20 9528932-11 1998 Exposure to IL-1beta resulted in 10-fold higher medium nitrite levels in both subpopulations; this effect was prevented by the iNOS blocker, N(G)-methyl-L-arginine, which also prevented the IL-1beta-induced suppression in the glucose-responsive subpopulation. Glucose 226-233 interleukin 1 beta Rattus norvegicus 190-198 9482808-11 1998 IS produced large increases in brain IL-1beta protein in the adrenalectomized subjects 2 hr after stress, whether basal corticosterone levels had been maintained. Corticosterone 120-134 interleukin 1 beta Rattus norvegicus 37-45 9482808-12 1998 Thus elimination of the stress-induced rise in corticosterone unmasked a robust and widespread increase in brain IL-1beta. Corticosterone 47-61 interleukin 1 beta Rattus norvegicus 113-121 9600668-5 1998 In addition, when rat aortic smooth muscle cells were treated with endotoxin or interleukin-1beta, they displayed lower sodium nitroprusside-induced cGMP accumulation as compared to control cells. Nitroprusside 120-140 interleukin 1 beta Rattus norvegicus 80-97 9600668-5 1998 In addition, when rat aortic smooth muscle cells were treated with endotoxin or interleukin-1beta, they displayed lower sodium nitroprusside-induced cGMP accumulation as compared to control cells. Cyclic GMP 149-153 interleukin 1 beta Rattus norvegicus 80-97 9559891-4 1998 Treatment of the isolated aortic rings with interleukin-1beta (IL-1beta, 20 micro ml(-1)) led to the expression of iNOS mRNA and protein, as well as significant nitrite accumulation in the incubation media and suppression of phenylephrine (1 nM-10 microM)-evoked contraction. Nitrites 161-168 interleukin 1 beta Rattus norvegicus 44-61 9559891-4 1998 Treatment of the isolated aortic rings with interleukin-1beta (IL-1beta, 20 micro ml(-1)) led to the expression of iNOS mRNA and protein, as well as significant nitrite accumulation in the incubation media and suppression of phenylephrine (1 nM-10 microM)-evoked contraction. Nitrites 161-168 interleukin 1 beta Rattus norvegicus 63-71 9559891-4 1998 Treatment of the isolated aortic rings with interleukin-1beta (IL-1beta, 20 micro ml(-1)) led to the expression of iNOS mRNA and protein, as well as significant nitrite accumulation in the incubation media and suppression of phenylephrine (1 nM-10 microM)-evoked contraction. Phenylephrine 225-238 interleukin 1 beta Rattus norvegicus 44-61 9559891-4 1998 Treatment of the isolated aortic rings with interleukin-1beta (IL-1beta, 20 micro ml(-1)) led to the expression of iNOS mRNA and protein, as well as significant nitrite accumulation in the incubation media and suppression of phenylephrine (1 nM-10 microM)-evoked contraction. Phenylephrine 225-238 interleukin 1 beta Rattus norvegicus 63-71 9559891-6 1998 Cycloheximide (1 microM), a protein synthesis inhibitor, prevented iNOS protein expression, nitrite accumulation and the suppression of contractility by IL-1beta on the isolated aortic rings. Cycloheximide 0-13 interleukin 1 beta Rattus norvegicus 153-161 9559891-7 1998 17Beta-oestradiol (1 nM-10 microM) and the partial oestrogen receptor agonist 4-OH-tamoxifen (1 nM-10 microM) produced concentration-dependent inhibition of IL-1beta-induced nitrite accumulation and restored vasoconstrictor responsiveness to phenylephrine, similar to the iNOS inhibitor aminoguanidine (100 microM). Estradiol 0-17 interleukin 1 beta Rattus norvegicus 157-165 9559891-7 1998 17Beta-oestradiol (1 nM-10 microM) and the partial oestrogen receptor agonist 4-OH-tamoxifen (1 nM-10 microM) produced concentration-dependent inhibition of IL-1beta-induced nitrite accumulation and restored vasoconstrictor responsiveness to phenylephrine, similar to the iNOS inhibitor aminoguanidine (100 microM). 4-oh-tamoxifen 78-92 interleukin 1 beta Rattus norvegicus 157-165 9559891-7 1998 17Beta-oestradiol (1 nM-10 microM) and the partial oestrogen receptor agonist 4-OH-tamoxifen (1 nM-10 microM) produced concentration-dependent inhibition of IL-1beta-induced nitrite accumulation and restored vasoconstrictor responsiveness to phenylephrine, similar to the iNOS inhibitor aminoguanidine (100 microM). Nitrites 174-181 interleukin 1 beta Rattus norvegicus 157-165 9559891-7 1998 17Beta-oestradiol (1 nM-10 microM) and the partial oestrogen receptor agonist 4-OH-tamoxifen (1 nM-10 microM) produced concentration-dependent inhibition of IL-1beta-induced nitrite accumulation and restored vasoconstrictor responsiveness to phenylephrine, similar to the iNOS inhibitor aminoguanidine (100 microM). Phenylephrine 242-255 interleukin 1 beta Rattus norvegicus 157-165 9610617-7 1998 Dexamethasone suppressed the IL-1beta-induced MCP-1 and CINC mRNA. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 29-37 9555020-8 1998 Inhibition of protein kinase C (PKC) by the potent and selective PKC inhibitor calphostin C converted the inhibitory action of PDGF into a bFGF-type of response thus suggesting that PKC is a major effector in PDGF-induced inhibition of IL-1beta-stimulated group II sPLA2 expression. calphostin C 79-91 interleukin 1 beta Rattus norvegicus 236-244 9510167-8 1998 IL-1beta appears to mediate the inhibitory actions of TNF + LPS on beta cell function as TNF + LPS-induced expression of IL-1beta is fourfold higher than IL-1alpha, and Ab neutralization of IL-1beta prevents TNF + LPS-induced nitrite production by rat islets. Nitrites 226-233 interleukin 1 beta Rattus norvegicus 0-8 9510167-8 1998 IL-1beta appears to mediate the inhibitory actions of TNF + LPS on beta cell function as TNF + LPS-induced expression of IL-1beta is fourfold higher than IL-1alpha, and Ab neutralization of IL-1beta prevents TNF + LPS-induced nitrite production by rat islets. Nitrites 226-233 interleukin 1 beta Rattus norvegicus 121-129 9510167-8 1998 IL-1beta appears to mediate the inhibitory actions of TNF + LPS on beta cell function as TNF + LPS-induced expression of IL-1beta is fourfold higher than IL-1alpha, and Ab neutralization of IL-1beta prevents TNF + LPS-induced nitrite production by rat islets. Nitrites 226-233 interleukin 1 beta Rattus norvegicus 121-129 9535019-0 1998 Inhibition of glycosphingolipid synthesis by threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) and the modulation of IL-1beta-stimulated expression of inducible nitric oxide synthase in rat aortic smooth muscle cells. Glycosphingolipids 14-31 interleukin 1 beta Rattus norvegicus 129-137 9535019-3 1998 In order to study the possible modulation of interleukin-1beta (IL-1beta)-induced expression of inducible nitric oxide synthase (iNOS) by endogenously synthesized glycosphingolipids, we investigated rat aortic vascular smooth muscle cells (VSMC) grown in the presence of the inhibitor of glycosphingolipid synthesis, threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP). Glycosphingolipids 163-181 interleukin 1 beta Rattus norvegicus 45-62 9535019-3 1998 In order to study the possible modulation of interleukin-1beta (IL-1beta)-induced expression of inducible nitric oxide synthase (iNOS) by endogenously synthesized glycosphingolipids, we investigated rat aortic vascular smooth muscle cells (VSMC) grown in the presence of the inhibitor of glycosphingolipid synthesis, threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP). Glycosphingolipids 163-181 interleukin 1 beta Rattus norvegicus 64-72 9535019-3 1998 In order to study the possible modulation of interleukin-1beta (IL-1beta)-induced expression of inducible nitric oxide synthase (iNOS) by endogenously synthesized glycosphingolipids, we investigated rat aortic vascular smooth muscle cells (VSMC) grown in the presence of the inhibitor of glycosphingolipid synthesis, threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP). Glycosphingolipids 163-180 interleukin 1 beta Rattus norvegicus 45-62 9535019-3 1998 In order to study the possible modulation of interleukin-1beta (IL-1beta)-induced expression of inducible nitric oxide synthase (iNOS) by endogenously synthesized glycosphingolipids, we investigated rat aortic vascular smooth muscle cells (VSMC) grown in the presence of the inhibitor of glycosphingolipid synthesis, threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP). Glycosphingolipids 163-180 interleukin 1 beta Rattus norvegicus 64-72 9535019-3 1998 In order to study the possible modulation of interleukin-1beta (IL-1beta)-induced expression of inducible nitric oxide synthase (iNOS) by endogenously synthesized glycosphingolipids, we investigated rat aortic vascular smooth muscle cells (VSMC) grown in the presence of the inhibitor of glycosphingolipid synthesis, threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP). RV 538 317-371 interleukin 1 beta Rattus norvegicus 45-62 9559891-15 1998 The anti-transforming growth factor-beta1 (TGF-beta1) antibody, which inhibited TGF-beta1-induced suppression of nitrite production from IL-1beta-treated vascular rings, did not affect the inhibitory action of 17beta-oestradiol, suggesting that the effect of oestrogen on iNOS inhibition was not mediated by TGF-beta1. Nitrites 113-120 interleukin 1 beta Rattus norvegicus 137-145 9602633-7 1998 DEX caused dose dependent inhibition of IL-1 induced IL-8 (p < 0.001) and MCP-1 (p < 0.05) secretion and mRNA expression at all concentrations of rIL-1 beta. Dexamethasone 0-3 interleukin 1 beta Rattus norvegicus 152-162 9559891-7 1998 17Beta-oestradiol (1 nM-10 microM) and the partial oestrogen receptor agonist 4-OH-tamoxifen (1 nM-10 microM) produced concentration-dependent inhibition of IL-1beta-induced nitrite accumulation and restored vasoconstrictor responsiveness to phenylephrine, similar to the iNOS inhibitor aminoguanidine (100 microM). pimagedine 287-301 interleukin 1 beta Rattus norvegicus 157-165 9559891-10 1998 Western blot analysis of rat aorta homogenates revealed that 17beta-oestradiol treatment resulted in a reduction in IL-1beta-induced iNOS protein level. Estradiol 61-78 interleukin 1 beta Rattus norvegicus 116-124 9535019-3 1998 In order to study the possible modulation of interleukin-1beta (IL-1beta)-induced expression of inducible nitric oxide synthase (iNOS) by endogenously synthesized glycosphingolipids, we investigated rat aortic vascular smooth muscle cells (VSMC) grown in the presence of the inhibitor of glycosphingolipid synthesis, threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP). RV 538 373-377 interleukin 1 beta Rattus norvegicus 45-62 9535019-3 1998 In order to study the possible modulation of interleukin-1beta (IL-1beta)-induced expression of inducible nitric oxide synthase (iNOS) by endogenously synthesized glycosphingolipids, we investigated rat aortic vascular smooth muscle cells (VSMC) grown in the presence of the inhibitor of glycosphingolipid synthesis, threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP). RV 538 373-377 interleukin 1 beta Rattus norvegicus 64-72 9535019-9 1998 In PDMP-treated VSMC, IL-1beta (3 micro ml[-1])-stimulated release of nitrite (135 +/- 4 nmol mg(-1) protein 48 h[-1]) was significantly increased as compared to IL-1beta-stimulated control cells (40 +/- 3 nmol mg(-1) protein 48 h(-1); n = 6, P < 0.001). RV 538 3-7 interleukin 1 beta Rattus norvegicus 22-30 9535019-9 1998 In PDMP-treated VSMC, IL-1beta (3 micro ml[-1])-stimulated release of nitrite (135 +/- 4 nmol mg(-1) protein 48 h[-1]) was significantly increased as compared to IL-1beta-stimulated control cells (40 +/- 3 nmol mg(-1) protein 48 h(-1); n = 6, P < 0.001). RV 538 3-7 interleukin 1 beta Rattus norvegicus 162-170 9535019-9 1998 In PDMP-treated VSMC, IL-1beta (3 micro ml[-1])-stimulated release of nitrite (135 +/- 4 nmol mg(-1) protein 48 h[-1]) was significantly increased as compared to IL-1beta-stimulated control cells (40 +/- 3 nmol mg(-1) protein 48 h(-1); n = 6, P < 0.001). vsmc 16-20 interleukin 1 beta Rattus norvegicus 22-30 9535019-9 1998 In PDMP-treated VSMC, IL-1beta (3 micro ml[-1])-stimulated release of nitrite (135 +/- 4 nmol mg(-1) protein 48 h[-1]) was significantly increased as compared to IL-1beta-stimulated control cells (40 +/- 3 nmol mg(-1) protein 48 h(-1); n = 6, P < 0.001). vsmc 16-20 interleukin 1 beta Rattus norvegicus 162-170 9535019-9 1998 In PDMP-treated VSMC, IL-1beta (3 micro ml[-1])-stimulated release of nitrite (135 +/- 4 nmol mg(-1) protein 48 h[-1]) was significantly increased as compared to IL-1beta-stimulated control cells (40 +/- 3 nmol mg(-1) protein 48 h(-1); n = 6, P < 0.001). Nitrites 70-77 interleukin 1 beta Rattus norvegicus 22-30 9535019-9 1998 In PDMP-treated VSMC, IL-1beta (3 micro ml[-1])-stimulated release of nitrite (135 +/- 4 nmol mg(-1) protein 48 h[-1]) was significantly increased as compared to IL-1beta-stimulated control cells (40 +/- 3 nmol mg(-1) protein 48 h(-1); n = 6, P < 0.001). Nitrites 70-77 interleukin 1 beta Rattus norvegicus 162-170 9535019-10 1998 Similarly, IL-1beta (3 micro ml(-1), 36 h)-stimulated release of nitric oxide was higher in PDMP-treated VSMC (6.1 +/- 0.5 nmol mg(-1) protein h[-1]) as compared to untreated cells (2.0 +/- 0.6 nmol mg(-1) protein h(-1); n = 3, P < 0.01). Nitric Oxide 65-77 interleukin 1 beta Rattus norvegicus 11-19 9535019-10 1998 Similarly, IL-1beta (3 micro ml(-1), 36 h)-stimulated release of nitric oxide was higher in PDMP-treated VSMC (6.1 +/- 0.5 nmol mg(-1) protein h[-1]) as compared to untreated cells (2.0 +/- 0.6 nmol mg(-1) protein h(-1); n = 3, P < 0.01). RV 538 92-96 interleukin 1 beta Rattus norvegicus 11-19 9535019-10 1998 Similarly, IL-1beta (3 micro ml(-1), 36 h)-stimulated release of nitric oxide was higher in PDMP-treated VSMC (6.1 +/- 0.5 nmol mg(-1) protein h[-1]) as compared to untreated cells (2.0 +/- 0.6 nmol mg(-1) protein h(-1); n = 3, P < 0.01). vsmc 105-109 interleukin 1 beta Rattus norvegicus 11-19 9539640-9 1998 Even when treated with mitomycin C, the inhibitory effect of IL-1beta on the enhanced wound repair was still observed; however, the extent of the inhibition was decreased. Mitomycin 23-34 interleukin 1 beta Rattus norvegicus 61-69 9492035-0 1998 The generation of nitric oxide and carbon monoxide produces opposite effects on the release of immunoreactive interleukin-1beta from the rat hypothalamus in vitro: evidence for the involvement of different signaling pathways. Nitric Oxide 18-30 interleukin 1 beta Rattus norvegicus 110-127 9492035-0 1998 The generation of nitric oxide and carbon monoxide produces opposite effects on the release of immunoreactive interleukin-1beta from the rat hypothalamus in vitro: evidence for the involvement of different signaling pathways. Carbon Monoxide 35-50 interleukin 1 beta Rattus norvegicus 110-127 9500699-0 1998 Interleukin 1beta-stimulated production of nitric oxide in rat hepatocytes is mediated through endogenous synthesis of interferon gamma. Nitric Oxide 43-55 interleukin 1 beta Rattus norvegicus 0-17 9462702-4 1998 IL-1beta significantly increased the uptake of [3H]thymidine in the HSCs, and the addition of OPC-15161 inhibited the uptake in a dose-dependent manner. [3h]thymidine 47-60 interleukin 1 beta Rattus norvegicus 0-8 9462702-9 1998 IL-1beta induced the increase of intracellular Ca2+ and IP3 concentrations in the HSCs, which were decreased by OPC-15161. Inositol 1,4,5-Trisphosphate 56-59 interleukin 1 beta Rattus norvegicus 0-8 9577844-3 1998 We set out to test the hypothesis that involvement of IL-1 beta in neurodegeneration results in some interaction with excitatory amino acid-mediated synaptic transmission in the rat striatum, either by modifying glutamate release or actions. Excitatory Amino Acids 118-139 interleukin 1 beta Rattus norvegicus 54-63 9577844-3 1998 We set out to test the hypothesis that involvement of IL-1 beta in neurodegeneration results in some interaction with excitatory amino acid-mediated synaptic transmission in the rat striatum, either by modifying glutamate release or actions. Glutamic Acid 212-221 interleukin 1 beta Rattus norvegicus 54-63 9468191-4 1998 PGD2 at a concentration of 10(-7) mol/L or greater dose-dependently inhibited nitrite accumulation in the medium of cultured VSMCs stimulated with interleukin 1beta (IL-1beta). Prostaglandin D2 0-4 interleukin 1 beta Rattus norvegicus 147-164 9482259-0 1998 GM1 ganglioside potentiates trimethyltin-induced expression of interleukin-1 beta and the nerve growth factor in reactive astrocytes in the rat hippocampus: an immunocytochemical study. G(M1) Ganglioside 0-15 interleukin 1 beta Rattus norvegicus 63-81 9482259-0 1998 GM1 ganglioside potentiates trimethyltin-induced expression of interleukin-1 beta and the nerve growth factor in reactive astrocytes in the rat hippocampus: an immunocytochemical study. trimethyltin 28-40 interleukin 1 beta Rattus norvegicus 63-81 9482259-2 1998 GM1 treatment also results in an increase of the number of IL-1 beta and NGF immunoreactive astrocytes. G(M1) Ganglioside 0-3 interleukin 1 beta Rattus norvegicus 59-68 9468191-4 1998 PGD2 at a concentration of 10(-7) mol/L or greater dose-dependently inhibited nitrite accumulation in the medium of cultured VSMCs stimulated with interleukin 1beta (IL-1beta). Prostaglandin D2 0-4 interleukin 1 beta Rattus norvegicus 166-174 9468191-4 1998 PGD2 at a concentration of 10(-7) mol/L or greater dose-dependently inhibited nitrite accumulation in the medium of cultured VSMCs stimulated with interleukin 1beta (IL-1beta). Nitrites 78-85 interleukin 1 beta Rattus norvegicus 147-164 9468191-4 1998 PGD2 at a concentration of 10(-7) mol/L or greater dose-dependently inhibited nitrite accumulation in the medium of cultured VSMCs stimulated with interleukin 1beta (IL-1beta). Nitrites 78-85 interleukin 1 beta Rattus norvegicus 166-174 9468191-5 1998 In a dose-response analysis of IL-1beta and nitrite accumulation, PGD2 was seen to decrease the maximal ability of VSMCs to generate NO, arguing against competition by PGD2 at cytokine receptors. Prostaglandin D2 66-70 interleukin 1 beta Rattus norvegicus 31-39 9468191-6 1998 Northern analysis showed that PGD2 suppresses induction of inducible NO synthase (iNOS) mRNA in IL-1beta-stimulated VSMCs, with consequent inhibition of iNOS protein expression in Western analysis. Prostaglandin D2 30-34 interleukin 1 beta Rattus norvegicus 96-104 9625457-0 1998 Interleukin-1beta administered intracerebroventricularly stimulates the release of noradrenaline in the hypothalamic paraventricular nucleus via prostaglandin in the rat. Norepinephrine 83-96 interleukin 1 beta Rattus norvegicus 0-17 9625457-0 1998 Interleukin-1beta administered intracerebroventricularly stimulates the release of noradrenaline in the hypothalamic paraventricular nucleus via prostaglandin in the rat. Prostaglandins 145-158 interleukin 1 beta Rattus norvegicus 0-17 9625457-2 1998 administration of interleukin (IL)-1beta on the rectal temperature and the release of noradrenaline (NA) in the hypothalamic paraventricular nucleus (PVN) of the rat. Norepinephrine 86-99 interleukin 1 beta Rattus norvegicus 18-40 9625457-4 1998 The stimulatory effect of IL-1beta on the release of NA was blocked by the subcutaneous injection of indomethacin. Indomethacin 101-113 interleukin 1 beta Rattus norvegicus 26-34 9625457-5 1998 These findings suggest that IL-1beta stimulates the release of NA in the PVN via prostaglandin, and that the release of NA in the PVN is not necessarily related to the increase in body temperature. Prostaglandins 81-94 interleukin 1 beta Rattus norvegicus 28-36 9541278-9 1998 also inhibited the increase in the serum free calcium concentration induced by continuous concomitant administration of both PTHrP and IL-1beta in a dose-dependent manner. Calcium 46-53 interleukin 1 beta Rattus norvegicus 135-143 9430720-1 1998 Activation of rat fibroblastic 3Y1 cells with interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha) induced delayed prostaglandin (PG) E2 generation over 6-48 h, which occurred in parallel with de novo induction of type IIA secretory phospholipase A2 (sPLA2) and cyclooxygenase (COX)-2, without accompanied by changes in the constitutive expression of type IV cytosolic PLA2 (cPLA2) and COX-1. Prostaglandins 137-150 interleukin 1 beta Rattus norvegicus 46-64 9430720-1 1998 Activation of rat fibroblastic 3Y1 cells with interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha) induced delayed prostaglandin (PG) E2 generation over 6-48 h, which occurred in parallel with de novo induction of type IIA secretory phospholipase A2 (sPLA2) and cyclooxygenase (COX)-2, without accompanied by changes in the constitutive expression of type IV cytosolic PLA2 (cPLA2) and COX-1. Prostaglandins 137-150 interleukin 1 beta Rattus norvegicus 66-75 9430720-8 1998 In contrast, Ca2+ ionophore-stimulated immediate PGE2 generation was regulated predominantly by the constitutive enzymes cPLA2 and COX-1, even when type IIA sPLA2 and COX-2 were maximally induced after IL-1 beta/TNF alpha treatment, revealing functional segregation of the constitutive and inducible PG biosynthetic enzymes. Prostaglandins 49-51 interleukin 1 beta Rattus norvegicus 202-211 9430720-1 1998 Activation of rat fibroblastic 3Y1 cells with interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha) induced delayed prostaglandin (PG) E2 generation over 6-48 h, which occurred in parallel with de novo induction of type IIA secretory phospholipase A2 (sPLA2) and cyclooxygenase (COX)-2, without accompanied by changes in the constitutive expression of type IV cytosolic PLA2 (cPLA2) and COX-1. Estradiol 156-158 interleukin 1 beta Rattus norvegicus 46-64 9430720-1 1998 Activation of rat fibroblastic 3Y1 cells with interleukin-1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha) induced delayed prostaglandin (PG) E2 generation over 6-48 h, which occurred in parallel with de novo induction of type IIA secretory phospholipase A2 (sPLA2) and cyclooxygenase (COX)-2, without accompanied by changes in the constitutive expression of type IV cytosolic PLA2 (cPLA2) and COX-1. Estradiol 156-158 interleukin 1 beta Rattus norvegicus 66-75 9430720-3 1998 Studies using an anti-type IIA sPLA2 antibody, sPLA2 inhibitors, and a type IIA sPLA2-specific antisense oligonucleotide revealed that IL-1 beta/TNF alpha-induced delayed PGE2 generation by these cells was largely dependent on inducible type IIA sPLA2, which was functionally linked to inducible COX-2. Oligonucleotides 105-120 interleukin 1 beta Rattus norvegicus 135-144 9430720-3 1998 Studies using an anti-type IIA sPLA2 antibody, sPLA2 inhibitors, and a type IIA sPLA2-specific antisense oligonucleotide revealed that IL-1 beta/TNF alpha-induced delayed PGE2 generation by these cells was largely dependent on inducible type IIA sPLA2, which was functionally linked to inducible COX-2. Dinoprostone 171-175 interleukin 1 beta Rattus norvegicus 135-144 9430720-7 1998 Some lipoxygenase-derived products might be involved in this event, since IL-1 beta/TNF alpha-induced type IIA sPLA2 induction and PGE2 generation were reduced markedly by lipoxygenase, but not COX, inhibitors. Dinoprostone 131-135 interleukin 1 beta Rattus norvegicus 74-83 9458787-7 1998 The NOS isoform induced by IL-1 beta and TNF-alpha was identified as NOS II by Western immunoblot analysis and confirmed by its 66-97% inhibition by 100 microM S-methylisothiourea, a selective NOS II inhibitor, and its Ca(2+)-independent activity. S-methylisothiopseudouronium 160-179 interleukin 1 beta Rattus norvegicus 27-36 9458734-1 1998 The effects of nitric oxide (NO) produced by cardiac inducible NO synthase (iNOS) on myocardial injury after oxidative stress were examined: Interleukin-1 beta induced cultured rat neonatal cardiac myocytes to express iNOS. Nitric Oxide 15-27 interleukin 1 beta Rattus norvegicus 141-159 9543248-11 1998 Thus, our results indicate that Zn2+ is capable of inhibiting lipopolysaccharide- or interleukin-1beta-induced NO formation as well as NO formation by constitutive NO synthase basally or in response to bradykinin or A-23187, and may explain the reported anti-inflammatory activity of Zn2+. Zinc 32-36 interleukin 1 beta Rattus norvegicus 85-102 9627106-2 1998 The purpose of this study was to investigate the role of endogenous nitric oxide in IL-1beta-induced fever in rats. Nitric Oxide 68-80 interleukin 1 beta Rattus norvegicus 84-92 9661135-0 1998 Atrial natriuretic peptide enhances IL-1 beta-stimulated nitric oxide production in cultured rat vascular smooth muscle cells. Nitric Oxide 57-69 interleukin 1 beta Rattus norvegicus 36-45 9661135-6 1998 RESULTS: IL-1 beta stimulated nitrite production in VSMC. Nitrites 30-37 interleukin 1 beta Rattus norvegicus 9-18 9661135-8 1998 Both 8-bromo-guanosine 3",5"-cyclic monophosphate (8-br-cGMP) and dibutylyl adenosine 3",5"-cyclic monophate enhanced IL-1 beta-induced nitrite production. 8-bromocyclic GMP 5-49 interleukin 1 beta Rattus norvegicus 118-127 9661135-8 1998 Both 8-bromo-guanosine 3",5"-cyclic monophosphate (8-br-cGMP) and dibutylyl adenosine 3",5"-cyclic monophate enhanced IL-1 beta-induced nitrite production. 8-bromoguanosino-3',5'-cyclic monophosphorothioate 51-60 interleukin 1 beta Rattus norvegicus 118-127 9661135-8 1998 Both 8-bromo-guanosine 3",5"-cyclic monophosphate (8-br-cGMP) and dibutylyl adenosine 3",5"-cyclic monophate enhanced IL-1 beta-induced nitrite production. dibutylyl adenosine 3",5"-cyclic monophate 66-108 interleukin 1 beta Rattus norvegicus 118-127 9661135-8 1998 Both 8-bromo-guanosine 3",5"-cyclic monophosphate (8-br-cGMP) and dibutylyl adenosine 3",5"-cyclic monophate enhanced IL-1 beta-induced nitrite production. Nitrites 136-143 interleukin 1 beta Rattus norvegicus 118-127 9661135-12 1998 CONCLUSIONS: ANP and cGMP enhanced IL-1 beta-induced NO production in VSMC. Cyclic GMP 21-25 interleukin 1 beta Rattus norvegicus 35-44 9718067-1 1998 Aspirin and sodium salicylate enhance to a similar extent the production of nitric oxide (NO) in cultured smooth muscle cells following stimulation by interleukin-1beta (IL-1beta). Aspirin 0-7 interleukin 1 beta Rattus norvegicus 151-168 9718067-1 1998 Aspirin and sodium salicylate enhance to a similar extent the production of nitric oxide (NO) in cultured smooth muscle cells following stimulation by interleukin-1beta (IL-1beta). Aspirin 0-7 interleukin 1 beta Rattus norvegicus 170-178 9718067-1 1998 Aspirin and sodium salicylate enhance to a similar extent the production of nitric oxide (NO) in cultured smooth muscle cells following stimulation by interleukin-1beta (IL-1beta). Sodium Salicylate 12-29 interleukin 1 beta Rattus norvegicus 151-168 9718067-1 1998 Aspirin and sodium salicylate enhance to a similar extent the production of nitric oxide (NO) in cultured smooth muscle cells following stimulation by interleukin-1beta (IL-1beta). Sodium Salicylate 12-29 interleukin 1 beta Rattus norvegicus 170-178 9481685-3 1998 Interleukin-1 beta (IL-1 beta) also induces neural colonic water hypersecretion involving the release of prostaglandins (PGs) and a mast cell degranulation in rats. Prostaglandins 105-119 interleukin 1 beta Rattus norvegicus 0-18 9481685-3 1998 Interleukin-1 beta (IL-1 beta) also induces neural colonic water hypersecretion involving the release of prostaglandins (PGs) and a mast cell degranulation in rats. Prostaglandins 105-119 interleukin 1 beta Rattus norvegicus 20-29 9481685-3 1998 Interleukin-1 beta (IL-1 beta) also induces neural colonic water hypersecretion involving the release of prostaglandins (PGs) and a mast cell degranulation in rats. Prostaglandins 121-124 interleukin 1 beta Rattus norvegicus 0-18 9481685-3 1998 Interleukin-1 beta (IL-1 beta) also induces neural colonic water hypersecretion involving the release of prostaglandins (PGs) and a mast cell degranulation in rats. Prostaglandins 121-124 interleukin 1 beta Rattus norvegicus 20-29 9481685-14 1998 Moreover, using SDS-PAGE immunoblotting the expression of IL-1 beta was detected in the brain. Sodium Dodecyl Sulfate 16-19 interleukin 1 beta Rattus norvegicus 58-67 9488111-8 1998 After CsA administration the IL-1beta mRNA was similar to control rats. Cyclosporine 6-9 interleukin 1 beta Rattus norvegicus 29-37 9585109-1 1998 The effects of the bacterial endotoxin lipopolysaccharide (LPS) and interleukin (IL)-1beta on corticosterone secretion has been studied in vivo by employing the technique of in situ perfusion of the isolated rat left adrenal gland. Corticosterone 94-108 interleukin 1 beta Rattus norvegicus 68-90 9585109-2 1998 Both LPS and IL-1beta dose-dependently raised corticosterone output, the response peaking at 60 and 90 min, respectively. Corticosterone 46-60 interleukin 1 beta Rattus norvegicus 13-21 9585109-4 1998 The IL-1beta converting enzyme (ICE) inhibitor Ac-YVAD-CMK annulled the adrenal response to LPS, but did not affect that to IL-1beta. ac-yvad 47-54 interleukin 1 beta Rattus norvegicus 4-12 9585124-2 1998 In primary cultured rat glial cells, a combination of inflammatory cytokines (tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta)) and bacterial lipopolysaccharide (LPS) stimulates production of nitrite via expression of the inducible form of nitric oxide synthase (iNOS). Nitrites 216-223 interleukin 1 beta Rattus norvegicus 122-139 9718067-1 1998 Aspirin and sodium salicylate enhance to a similar extent the production of nitric oxide (NO) in cultured smooth muscle cells following stimulation by interleukin-1beta (IL-1beta). Nitric Oxide 76-88 interleukin 1 beta Rattus norvegicus 151-168 9718067-1 1998 Aspirin and sodium salicylate enhance to a similar extent the production of nitric oxide (NO) in cultured smooth muscle cells following stimulation by interleukin-1beta (IL-1beta). Nitric Oxide 76-88 interleukin 1 beta Rattus norvegicus 170-178 9718067-5 1998 Aspirin and sodium salicylate enhance the induction of iNOS expression by IL-1beta. Aspirin 0-7 interleukin 1 beta Rattus norvegicus 74-82 9718067-5 1998 Aspirin and sodium salicylate enhance the induction of iNOS expression by IL-1beta. Sodium Salicylate 12-29 interleukin 1 beta Rattus norvegicus 74-82 9718067-6 1998 We previously reported that pretreatment of vascular smooth muscle cells (VSMCs) with high glucose decreased the response of the cells by IL-1beta, that is, the induction of iNOS expression and NO production. Glucose 91-98 interleukin 1 beta Rattus norvegicus 138-146 9718067-7 1998 We investigated the effect of aspirin and sodium salicylate on the response by IL-1beta of VSMCs pretreated with high glucose (25 mM). Aspirin 30-37 interleukin 1 beta Rattus norvegicus 79-87 9718067-7 1998 We investigated the effect of aspirin and sodium salicylate on the response by IL-1beta of VSMCs pretreated with high glucose (25 mM). Sodium Salicylate 42-59 interleukin 1 beta Rattus norvegicus 79-87 9627106-6 1998 injection of 50 mg/kg N-nitro-L-arginine methyl ester hydrochloride (L-NAME) resulted in a complete suppression of IL-1beta-induced fever in rats. L-NAME hydrochloride 22-67 interleukin 1 beta Rattus norvegicus 115-123 9718067-7 1998 We investigated the effect of aspirin and sodium salicylate on the response by IL-1beta of VSMCs pretreated with high glucose (25 mM). Glucose 118-125 interleukin 1 beta Rattus norvegicus 79-87 9627106-6 1998 injection of 50 mg/kg N-nitro-L-arginine methyl ester hydrochloride (L-NAME) resulted in a complete suppression of IL-1beta-induced fever in rats. NG-Nitroarginine Methyl Ester 69-75 interleukin 1 beta Rattus norvegicus 115-123 9627106-9 1998 Endogenous formation of IL-6 in response to IL-1beta was not suppressed but rather enhanced by treatment with L-NAME during the early stage of IL-1beta-induced fever. NG-Nitroarginine Methyl Ester 110-116 interleukin 1 beta Rattus norvegicus 44-52 9627106-9 1998 Endogenous formation of IL-6 in response to IL-1beta was not suppressed but rather enhanced by treatment with L-NAME during the early stage of IL-1beta-induced fever. NG-Nitroarginine Methyl Ester 110-116 interleukin 1 beta Rattus norvegicus 143-151 9627106-10 1998 This result indicates that activation of nitric oxide synthase and thereby endogenous NO-formation is essential for the generation of an IL-1beta-induced febrile response in rats and that the suppression of IL-1beta-induced fever by treatment with L-NAME seems not to be caused by an inhibition of IL-6 production. NG-Nitroarginine Methyl Ester 248-254 interleukin 1 beta Rattus norvegicus 137-145 9627106-10 1998 This result indicates that activation of nitric oxide synthase and thereby endogenous NO-formation is essential for the generation of an IL-1beta-induced febrile response in rats and that the suppression of IL-1beta-induced fever by treatment with L-NAME seems not to be caused by an inhibition of IL-6 production. NG-Nitroarginine Methyl Ester 248-254 interleukin 1 beta Rattus norvegicus 207-215 9825769-8 1998 The effect of IL-1beta on the hexose transport across the brush border membrane may thus be attributed to its inhibitory effect on the Na+-K+ ATPase. Hexoses 30-36 interleukin 1 beta Rattus norvegicus 14-22 9825769-0 1998 Interleukin-1 beta inhibits the intestinal transport of [14C] 3-O-methylglucose in the rat. Carbon-14 57-60 interleukin 1 beta Rattus norvegicus 0-18 9438531-3 1997 To further test this hypothesis, we determined whether an initial alcohol challenge would alter the ACTH response to immune signals, such as interleukin-1beta (IL-1beta) and/or endotoxin (lipopolysaccharide; LPS). Alcohols 66-73 interleukin 1 beta Rattus norvegicus 141-158 9825769-0 1998 Interleukin-1 beta inhibits the intestinal transport of [14C] 3-O-methylglucose in the rat. 3-O-Methylglucose 62-79 interleukin 1 beta Rattus norvegicus 0-18 9825769-2 1998 Since the blood glucose levels depend on the amount of glucose entering and leaving the circulation, this work was conducted to test the hypothesis that the hypoglycemia observed with IL-1beta might result, at least partially, from a reduced intestinal glucose absorption. Glucose 16-23 interleukin 1 beta Rattus norvegicus 184-192 9825769-2 1998 Since the blood glucose levels depend on the amount of glucose entering and leaving the circulation, this work was conducted to test the hypothesis that the hypoglycemia observed with IL-1beta might result, at least partially, from a reduced intestinal glucose absorption. Glucose 55-62 interleukin 1 beta Rattus norvegicus 184-192 9825769-5 1998 Our results showed that IL-1beta significantly inhibited the mucosal uptake of this hexose and reduced its intestinal retention. Hexoses 84-90 interleukin 1 beta Rattus norvegicus 24-32 9786178-7 1998 Dexamethasone (0.5 mg/kg, s.c., 4 h) or cycloheximide (1.5 mg/kg, s.c., 6 h) significantly prevented the edema caused by des-Arg9-bradykinin (100 nmol) in rats treated with IL-1beta (81 +/- 5% and 59 +/- 3%) or TNF alpha (78 +/- 4% and 43 +/- 2%). Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 173-181 9786178-7 1998 Dexamethasone (0.5 mg/kg, s.c., 4 h) or cycloheximide (1.5 mg/kg, s.c., 6 h) significantly prevented the edema caused by des-Arg9-bradykinin (100 nmol) in rats treated with IL-1beta (81 +/- 5% and 59 +/- 3%) or TNF alpha (78 +/- 4% and 43 +/- 2%). Cycloheximide 40-53 interleukin 1 beta Rattus norvegicus 173-181 9786178-12 1998 injection of the IL-1beta or TNF alpha, produced up-regulation of B1 receptor-mediated paw edema, being this effect sensitive to dexamethasone and cycloheximide and to cyclo-oxygenase pathway. Dexamethasone 129-142 interleukin 1 beta Rattus norvegicus 17-25 9786178-12 1998 injection of the IL-1beta or TNF alpha, produced up-regulation of B1 receptor-mediated paw edema, being this effect sensitive to dexamethasone and cycloheximide and to cyclo-oxygenase pathway. Cycloheximide 147-160 interleukin 1 beta Rattus norvegicus 17-25 9389514-2 1997 Treatment of rat islets for 18 h with IL-1beta results in an inhibition of glucose-stimulated insulin secretion, mitochondrial aconitase activity, and total protein synthesis. Glucose 75-82 interleukin 1 beta Rattus norvegicus 38-46 9769476-4 1998 Our study demonstrates that CINC can be induced in bone marrow-derived macrophages by lipopolysaccharide, interleukin-1 beta, tumor necrosis factor-alpha (TNFalpha), and interferon-gamma/TNF alpha. Zinc 28-32 interleukin 1 beta Rattus norvegicus 106-124 9438531-3 1997 To further test this hypothesis, we determined whether an initial alcohol challenge would alter the ACTH response to immune signals, such as interleukin-1beta (IL-1beta) and/or endotoxin (lipopolysaccharide; LPS). Alcohols 66-73 interleukin 1 beta Rattus norvegicus 160-168 9395303-1 1997 We have previously observed that treatment of rat islets of Langerhans with interleukin-1beta for 12 h results in nitric oxide-dependent inhibition of insulin secretion, while 48 h treatment increased rates of islet cell death by apoptosis. Nitric Oxide 114-126 interleukin 1 beta Rattus norvegicus 76-93 9389730-6 1997 In addition to iNOS, lovastatin and NaPA also inhibited LPS-induced expression of TNF-alpha, IL-1beta, and IL-6 in rat primary astrocytes, microglia, and macrophages. Lovastatin 21-31 interleukin 1 beta Rattus norvegicus 93-101 9389730-6 1997 In addition to iNOS, lovastatin and NaPA also inhibited LPS-induced expression of TNF-alpha, IL-1beta, and IL-6 in rat primary astrocytes, microglia, and macrophages. Acecainide 36-40 interleukin 1 beta Rattus norvegicus 93-101 9389745-4 1997 Treatment of mesangial cells with IL-1beta induces iNOS activity measured as nitrite levels in cell culture supernatants. Nitrites 77-84 interleukin 1 beta Rattus norvegicus 34-42 9389745-6 1997 This effect can be reversed by the simultaneous incubation of PDGF-BB in the presence of calphostin C, a potent and selective inhibitor of protein kinase C. In contrast, incubation of cells in the presence of bFGF potentiates IL-1beta-induced production of NO and is functionally associated with an increased rate of apoptosis of mesangial cells. calphostin complex 89-99 interleukin 1 beta Rattus norvegicus 226-234 9444610-2 1997 Here we investigate the role of endogenous TNF alpha and IL-1 beta on (i) the circulatory failure, (ii) the multiple organ dysfunction syndrome (MODS) and (iii) the induction of the inducible isoform of nitric oxide (NO) synthase (iNOS) caused by endotoxin (LPS) in the anaesthetised rat. Nitric Oxide 203-215 interleukin 1 beta Rattus norvegicus 57-66 9488002-2 1997 Treatment of RINm5F cells for 24 h with interleukin-1 beta (IL-1 beta) (100 pM) induced expression of nitric oxide synthase and inhibited glyceraldehyde-stimulated insulin secretion. Glyceraldehyde 138-152 interleukin 1 beta Rattus norvegicus 40-58 9488002-2 1997 Treatment of RINm5F cells for 24 h with interleukin-1 beta (IL-1 beta) (100 pM) induced expression of nitric oxide synthase and inhibited glyceraldehyde-stimulated insulin secretion. Glyceraldehyde 138-152 interleukin 1 beta Rattus norvegicus 60-69 9488002-3 1997 Combinations of IL-1 beta (100 pM), tumour necrosis factor-alpha (100 pM) and interferon-gamma (100 pM) reduced RINm5F cell viability (determined by the 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium (MTT) reduction assay) and de novo protein synthesis, as measured by incorporation of radiolabelled amino acids into perchloric acid-precipitable protein. rinm5f 112-118 interleukin 1 beta Rattus norvegicus 16-25 9488002-3 1997 Combinations of IL-1 beta (100 pM), tumour necrosis factor-alpha (100 pM) and interferon-gamma (100 pM) reduced RINm5F cell viability (determined by the 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium (MTT) reduction assay) and de novo protein synthesis, as measured by incorporation of radiolabelled amino acids into perchloric acid-precipitable protein. 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium 153-204 interleukin 1 beta Rattus norvegicus 16-25 9488002-3 1997 Combinations of IL-1 beta (100 pM), tumour necrosis factor-alpha (100 pM) and interferon-gamma (100 pM) reduced RINm5F cell viability (determined by the 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium (MTT) reduction assay) and de novo protein synthesis, as measured by incorporation of radiolabelled amino acids into perchloric acid-precipitable protein. monooxyethylene trimethylolpropane tristearate 206-209 interleukin 1 beta Rattus norvegicus 16-25 9488002-3 1997 Combinations of IL-1 beta (100 pM), tumour necrosis factor-alpha (100 pM) and interferon-gamma (100 pM) reduced RINm5F cell viability (determined by the 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium (MTT) reduction assay) and de novo protein synthesis, as measured by incorporation of radiolabelled amino acids into perchloric acid-precipitable protein. Perchloric Acid 322-337 interleukin 1 beta Rattus norvegicus 16-25 9420100-10 1997 L-Arginine decreased alveolar macrophage TNFalpha and IL-1beta release during acute lung injury. Arginine 0-10 interleukin 1 beta Rattus norvegicus 54-62 9395303-2 1997 Here, we demonstrate that interleukin-1beta-mediated nitric oxide formation and inhibition of insulin secretion are significantly reduced by 24 h pretreatment of rat islets of Langerhans with insulin-like growth factor I (IGF-I). Nitric Oxide 53-65 interleukin 1 beta Rattus norvegicus 26-43 9375806-4 1997 We show that the interleukin-1 receptor antagonist protein (IRAP) prevents IL-1beta-induced nitrite formation and IL-1beta-induced inhibition of insulin secretion by isolated islets and primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitrites 92-99 interleukin 1 beta Rattus norvegicus 75-83 9351439-3 1997 The IL-1 beta mRNA content in the LV of DS rats increased 3.9-fold when LV hypertrophy developed, and the increase reached 6.2-fold at the CHF stage compared with that of age-matched Dahl salt-resistant (DR) rats. dahl salt 183-192 interleukin 1 beta Rattus norvegicus 4-13 9369275-8 1997 In the aortic rings with endothelium, either inhibition of the AT-1 receptor with losartan or blocking of angiotensin II generation with fosinopril enhanced interleukin-1beta-stimulated inducible nitric oxide synthase protein expression. Losartan 82-90 interleukin 1 beta Rattus norvegicus 157-174 9369275-8 1997 In the aortic rings with endothelium, either inhibition of the AT-1 receptor with losartan or blocking of angiotensin II generation with fosinopril enhanced interleukin-1beta-stimulated inducible nitric oxide synthase protein expression. Fosinopril 137-147 interleukin 1 beta Rattus norvegicus 157-174 9375806-1 1997 The cytokine interleukin-1beta (IL-1beta) has been shown to inhibit insulin secretion and destroy pancreatic islets by a mechanism that involves the expression of inducible nitric oxide synthase (iNOS), and the production of nitric oxide (NO). Nitric Oxide 173-185 interleukin 1 beta Rattus norvegicus 13-30 9375806-1 1997 The cytokine interleukin-1beta (IL-1beta) has been shown to inhibit insulin secretion and destroy pancreatic islets by a mechanism that involves the expression of inducible nitric oxide synthase (iNOS), and the production of nitric oxide (NO). Nitric Oxide 173-185 interleukin 1 beta Rattus norvegicus 32-40 9369275-0 1997 Endogenous angiotensin II produced by endothelium regulates interleukin-1beta-stimulated nitric oxide generation in rat isolated vessels. Nitric Oxide 89-101 interleukin 1 beta Rattus norvegicus 60-77 9369275-4 1997 Interleukin-1beta (0.03 U/L) stimulated nitrite release by the aortic vessels. Nitrites 40-47 interleukin 1 beta Rattus norvegicus 0-17 9375806-6 1997 To provide direct evidence to support beta-cell expression of IL-1 type I signaling receptors, we show that antiserum specific for the type I IL-1 receptor neutralizes IL-1beta-induced nitrite formation by RINm5F cells, and that RINm5F cells express the type I IL-1 receptor at the protein level. Nitrites 185-192 interleukin 1 beta Rattus norvegicus 168-176 9366243-1 1997 Incubation of rat glomerular mesangial cells with potent proinflammatory cytokines like interleukin 1beta, (IL- 1beta) triggers the expression of a non-pancreatic secretory phospholipase A2 (sPLA2) and increases the formation of prostaglandin E2. Dinoprostone 229-245 interleukin 1 beta Rattus norvegicus 88-105 9366243-1 1997 Incubation of rat glomerular mesangial cells with potent proinflammatory cytokines like interleukin 1beta, (IL- 1beta) triggers the expression of a non-pancreatic secretory phospholipase A2 (sPLA2) and increases the formation of prostaglandin E2. Dinoprostone 229-245 interleukin 1 beta Rattus norvegicus 108-117 9354589-2 1997 Interleukin-1beta (IL-1beta) also reduces CYP4A1-related 12-laurate hydroxylase activity in cultured fetal rat hepatocytes after induction by clofibric acid. Clofibric Acid 142-156 interleukin 1 beta Rattus norvegicus 0-17 9354589-2 1997 Interleukin-1beta (IL-1beta) also reduces CYP4A1-related 12-laurate hydroxylase activity in cultured fetal rat hepatocytes after induction by clofibric acid. Clofibric Acid 142-156 interleukin 1 beta Rattus norvegicus 19-27 9354589-7 1997 It was found that IL-1beta and IL-6 both repress the induction of PPAR alpha expression exerted by the combined action of clofibric acid and dexamethasone. Clofibric Acid 122-136 interleukin 1 beta Rattus norvegicus 18-26 9354589-7 1997 It was found that IL-1beta and IL-6 both repress the induction of PPAR alpha expression exerted by the combined action of clofibric acid and dexamethasone. Dexamethasone 141-154 interleukin 1 beta Rattus norvegicus 18-26 9333116-10 1997 Levels of IL-1beta, but not IL-1alpha, were affected by the vitamin D status of the animal. Vitamin D 60-69 interleukin 1 beta Rattus norvegicus 10-18 9408009-3 1997 Incubation of the cultures with interleukin-1beta (10 ng/ml) caused a significant increase in nitrite production. Nitrites 94-101 interleukin 1 beta Rattus norvegicus 32-49 9408009-4 1997 5-HT inhibited nitrite production by interleukin-1beta -stimulated vascular smooth muscle cells in a concentration-dependent manner (10(-8)-10(-5) M). Nitrites 15-22 interleukin 1 beta Rattus norvegicus 37-54 9351511-0 1997 Differential effect of dexamethasone on interleukin 1beta- and cyclic AMP-triggered expression of GTP cyclohydrolase I in rat renal mesangial cells. Dexamethasone 23-36 interleukin 1 beta Rattus norvegicus 40-57 9351511-6 1997 We examined the action of the potent anti-inflammatory drug dexamethasone on GTP cyclohydrolase I induction in response to IL-1beta and a membrane-permeable cyclic AMP analogue, N6, O-2"-dibutyryladenosine 3"-5"-phosphate (Bt2cyclic AMP). Dexamethasone 60-73 interleukin 1 beta Rattus norvegicus 123-131 9351511-8 1997 Nanomolar concentrations of dexamethasone markedly attenuated IL-1beta-induced GTP cyclohydrolase I mRNA steady state level as well as IL-1beta-induced GTP cyclohydrolase I protein expression and enzyme activity. Dexamethasone 28-41 interleukin 1 beta Rattus norvegicus 62-70 9351511-8 1997 Nanomolar concentrations of dexamethasone markedly attenuated IL-1beta-induced GTP cyclohydrolase I mRNA steady state level as well as IL-1beta-induced GTP cyclohydrolase I protein expression and enzyme activity. Dexamethasone 28-41 interleukin 1 beta Rattus norvegicus 135-143 9420175-13 1997 In conclusion, we present the first 10% and 15% acrylamide 2-D gel protein databases of neonatal rat islets of Langerhans and demonstrate its usage to identify proteins altered in expression by IL-1beta. Acrylamide 48-58 interleukin 1 beta Rattus norvegicus 194-202 9336394-0 1997 Parathyroid hormone-related protein upregulates interleukin-1beta-induced nitric oxide synthesis. Nitric Oxide 74-86 interleukin 1 beta Rattus norvegicus 48-65 9336394-1 1997 The effect of parathyroid hormone-related protein on interleukin-1beta-induced nitric oxide production was studied in rat vascular smooth muscle cells. Nitric Oxide 79-91 interleukin 1 beta Rattus norvegicus 53-70 9336394-2 1997 Interleukin-1beta time- and dose-dependently enhanced the production of nitrite, a stable metabolite of nitric oxide. Nitrites 72-79 interleukin 1 beta Rattus norvegicus 0-17 9336394-2 1997 Interleukin-1beta time- and dose-dependently enhanced the production of nitrite, a stable metabolite of nitric oxide. Nitric Oxide 104-116 interleukin 1 beta Rattus norvegicus 0-17 9336394-8 1997 These results suggest that locally produced parathyroid hormone-related protein acts as a synergistic regulator upregulating interleukin-1beta-induced nitric oxide synthesis in the cardiovascular system, and thereby may affect vascular tone and/or vascular remodeling after vascular injury in some pathological processes such as atherosclerosis and hypertension. Nitric Oxide 151-163 interleukin 1 beta Rattus norvegicus 125-142 9314830-9 1997 Studies performed in the presence of second-messenger inhibitors showed that the effect of IL-1 beta on phospholamban transcript levels was blocked by dexamethasone, was insensitive to inhibitors of iNOS, cyclooxygenase, or tyrosine kinases, but was enhanced by the addition of the protein kinase inhibitor staurosporine. Dexamethasone 151-164 interleukin 1 beta Rattus norvegicus 91-100 9314830-9 1997 Studies performed in the presence of second-messenger inhibitors showed that the effect of IL-1 beta on phospholamban transcript levels was blocked by dexamethasone, was insensitive to inhibitors of iNOS, cyclooxygenase, or tyrosine kinases, but was enhanced by the addition of the protein kinase inhibitor staurosporine. Staurosporine 307-320 interleukin 1 beta Rattus norvegicus 91-100 9402221-9 1997 Taken together, these results show that IL-1beta, IL-6, and TNF-alpha can affect developing monoamine neurons at physiologically relevant concentrations, and that high doses differentially inhibit the survival of TH and 5-HT neurons after short exposures. monoamine 92-101 interleukin 1 beta Rattus norvegicus 40-48 9312173-0 1997 Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity. Troglitazone 11-23 interleukin 1 beta Rattus norvegicus 63-80 9312173-3 1997 Since long-chain fatty acids (FFA), like IL-1beta, upregulate inducible nitric oxide synthase and enhance NO generation in islets, it seemed possible that islets might be protected from IL-1beta-induced damage by lowering their lipid content. long-chain fatty acids 6-28 interleukin 1 beta Rattus norvegicus 186-194 9312173-4 1997 We found that IL-1beta-induced NO production varied directly and islet cell viability inversely with islet triglyceride (TG) content. Triglycerides 107-119 interleukin 1 beta Rattus norvegicus 14-22 9312173-4 1997 We found that IL-1beta-induced NO production varied directly and islet cell viability inversely with islet triglyceride (TG) content. Triglycerides 121-123 interleukin 1 beta Rattus norvegicus 14-22 9294201-9 1997 Butyrate enhanced MIP-2 secretion both in lipopolysaccharide-stimulated and IL-1beta-stimulated enterocytes; but butyrate alone did not induce MIP-2 expression. Butyrates 0-8 interleukin 1 beta Rattus norvegicus 76-84 9359471-0 1997 Interleukin-1 beta inhibits progesterone accumulation in rat corpora luteal cell cultures in a mechanism dissociated from its effects on nitric oxide and prostaglandin E accumulation. Nitric Oxide 137-149 interleukin 1 beta Rattus norvegicus 0-18 9359471-0 1997 Interleukin-1 beta inhibits progesterone accumulation in rat corpora luteal cell cultures in a mechanism dissociated from its effects on nitric oxide and prostaglandin E accumulation. Prostaglandins E 154-169 interleukin 1 beta Rattus norvegicus 0-18 9359471-1 1997 The objective of this study was to examine the effect of interleukin-1 beta (IL-1) on progesterone (P) biosynthesis and the potential intermediary involvement of prostaglandin (PG) E and nitric oxide (NO) in P accumulation in PMSG/hCG-primed rat corpora luteal (CL) cell cultures. Progesterone 86-98 interleukin 1 beta Rattus norvegicus 57-75 9294201-11 1997 Furthermore, acetylation of histones (induced by trichostatin A, a specific inhibitor of histone deacetylase) enhanced MIP-2 expression by cells stimulated with IL-1beta. trichostatin A 49-63 interleukin 1 beta Rattus norvegicus 161-169 9369341-0 1997 Intracerebroventricular injection of isoproterenol produces its analgesic effect through interleukin-1beta production. Isoproterenol 37-50 interleukin 1 beta Rattus norvegicus 89-106 9310350-0 1997 Nitric oxide-independent suppression of P450 2C11 expression by interleukin-1beta and endotoxin in primary rat hepatocytes. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 64-81 9310350-8 1997 To investigate the role of NO in the IL-1beta- or LPS-mediated suppression of P450 2C11, N-monomethyl-L-arginine (NMA) was administered at concentrations ranging from 30 to 300 microM. omega-N-Methylarginine 114-117 interleukin 1 beta Rattus norvegicus 37-45 9321887-5 1997 In addition, LPS and IL-1 beta (1 microgram/kg) inhibited the increase in EPO mRNA and plasma EPO levels when administered to rats before hypoxia exposure (8% O2 in the inspiratory gas). Oxygen 159-161 interleukin 1 beta Rattus norvegicus 21-30 9417804-7 1997 On the other hand, the tripeptide lys-D-pro-val (known to antagonize IL-1 beta and PGE2 induced hyperalgesia) reversed the hyperalgesia due to thymulin. Thymic Factor, Circulating 143-151 interleukin 1 beta Rattus norvegicus 69-78 9282331-0 1997 Induction of intracellular ceramide by interleukin-1 beta in oligodendrocytes. Ceramides 27-35 interleukin 1 beta Rattus norvegicus 39-57 9282331-8 1997 Surprisingly, long-term exposure (72 h) to increasing concentrations of IL-1 beta, which increases intracellular ceramide, did not induce oligodendroglial cell death. Ceramides 113-121 interleukin 1 beta Rattus norvegicus 72-81 9282331-9 1997 These results show that an increase of intracellular ceramide is not sufficient to induce apoptosis in oligodendrocytes and that IL-1 beta signaling through the ceramide pathway in these cells can mediate functions other than programmed cell death. Ceramides 161-169 interleukin 1 beta Rattus norvegicus 129-138 9321873-3 1997 IL-1 beta was administered either intracerebroventricularly or intraperitoneally at the dose of 400 ng to rats pretreated with the mu-antagonist beta-funaltrexamine, the delta-antagonist naltrindole, or the kappa-antagonist nor-binaltorphimine, each at the doses of 1, 10, and 100 micrograms/rat intracerebroventricularly. beta-funaltrexamine 145-164 interleukin 1 beta Rattus norvegicus 0-9 9321873-3 1997 IL-1 beta was administered either intracerebroventricularly or intraperitoneally at the dose of 400 ng to rats pretreated with the mu-antagonist beta-funaltrexamine, the delta-antagonist naltrindole, or the kappa-antagonist nor-binaltorphimine, each at the doses of 1, 10, and 100 micrograms/rat intracerebroventricularly. 19-norandrostenedione 224-227 interleukin 1 beta Rattus norvegicus 0-9 9321873-3 1997 IL-1 beta was administered either intracerebroventricularly or intraperitoneally at the dose of 400 ng to rats pretreated with the mu-antagonist beta-funaltrexamine, the delta-antagonist naltrindole, or the kappa-antagonist nor-binaltorphimine, each at the doses of 1, 10, and 100 micrograms/rat intracerebroventricularly. binaltorphimine 228-243 interleukin 1 beta Rattus norvegicus 0-9 9417804-0 1997 Involvement of interleukin-1 beta, nerve growth factor, and prostaglandin-E2 in the hyperalgesia induced by intraplantar injections of low doses of thymulin. Thymic Factor, Circulating 148-156 interleukin 1 beta Rattus norvegicus 15-33 9417804-7 1997 On the other hand, the tripeptide lys-D-pro-val (known to antagonize IL-1 beta and PGE2 induced hyperalgesia) reversed the hyperalgesia due to thymulin. tripeptide K-26 23-33 interleukin 1 beta Rattus norvegicus 69-78 9417804-7 1997 On the other hand, the tripeptide lys-D-pro-val (known to antagonize IL-1 beta and PGE2 induced hyperalgesia) reversed the hyperalgesia due to thymulin. lys-d-pro-val 34-47 interleukin 1 beta Rattus norvegicus 69-78 9369341-1 1997 The effects of isoproterenol, a beta-adrenoceptor agonist, on the production of interleukin-1beta in the brain and on mechanical nociception were examined in rats. Isoproterenol 15-28 interleukin 1 beta Rattus norvegicus 80-97 9369341-3 1997 injection of isoproterenol at the dose of 3 microg/rat markedly induced interleukin-1beta mRNA in the molecular layer of the hippocampus, medial preoptic area, paraventricular thalamic nucleus, paraventricular hypothalamic nucleus, ventromedial hypothalamic nucleus, dorsomedial hypothalamic nucleus and central gray 1 h after injection. Isoproterenol 13-26 interleukin 1 beta Rattus norvegicus 72-89 9369341-10 1997 These results suggest that isoproterenol produces an analgesic effect, at least in part, through the induction of interleukin-1beta expression in the brain. Isoproterenol 27-40 interleukin 1 beta Rattus norvegicus 114-131 9339386-3 1997 RESULTS: Addition of TGF-beta 2 dose-dependently suppresses IL-1 beta-induced nitrite formation. Nitrites 78-85 interleukin 1 beta Rattus norvegicus 60-69 9330595-2 1997 Since PGE2, NO and IL-1 beta have been implicated as modulators of steroidogenesis, experiments have been undertaken to determine how IL-1 beta-induced NO and PGE2 production may affect steroidogenesis in cultures of ovarian dispersates obtained from untreated adult oestrous rats and to compare the action of IL-1 beta in cultures of granulosa/luteal (GL) cell-only cultures and GL cells co-cultured with peritoneal macrophages. Dinoprostone 6-10 interleukin 1 beta Rattus norvegicus 134-143 9330595-2 1997 Since PGE2, NO and IL-1 beta have been implicated as modulators of steroidogenesis, experiments have been undertaken to determine how IL-1 beta-induced NO and PGE2 production may affect steroidogenesis in cultures of ovarian dispersates obtained from untreated adult oestrous rats and to compare the action of IL-1 beta in cultures of granulosa/luteal (GL) cell-only cultures and GL cells co-cultured with peritoneal macrophages. Dinoprostone 6-10 interleukin 1 beta Rattus norvegicus 134-143 9330595-2 1997 Since PGE2, NO and IL-1 beta have been implicated as modulators of steroidogenesis, experiments have been undertaken to determine how IL-1 beta-induced NO and PGE2 production may affect steroidogenesis in cultures of ovarian dispersates obtained from untreated adult oestrous rats and to compare the action of IL-1 beta in cultures of granulosa/luteal (GL) cell-only cultures and GL cells co-cultured with peritoneal macrophages. Dinoprostone 159-163 interleukin 1 beta Rattus norvegicus 134-143 9330595-2 1997 Since PGE2, NO and IL-1 beta have been implicated as modulators of steroidogenesis, experiments have been undertaken to determine how IL-1 beta-induced NO and PGE2 production may affect steroidogenesis in cultures of ovarian dispersates obtained from untreated adult oestrous rats and to compare the action of IL-1 beta in cultures of granulosa/luteal (GL) cell-only cultures and GL cells co-cultured with peritoneal macrophages. Dinoprostone 159-163 interleukin 1 beta Rattus norvegicus 134-143 9330595-3 1997 IL-1 beta significantly increased the production of NO (assessed by nitrite measured in the culture medium) and PGE2 in cultures of ovarian dispersates but had no effect on cultures of GL cells in which NO production was typically very low and PGE2 production was undetectable. Nitrites 68-75 interleukin 1 beta Rattus norvegicus 0-9 9330595-3 1997 IL-1 beta significantly increased the production of NO (assessed by nitrite measured in the culture medium) and PGE2 in cultures of ovarian dispersates but had no effect on cultures of GL cells in which NO production was typically very low and PGE2 production was undetectable. Dinoprostone 112-116 interleukin 1 beta Rattus norvegicus 0-9 9330595-7 1997 Finally, IL-1 beta inhibited progesterone responses to forskolin and PGE2 in ovarian dispersates: an effect not observed in GL cell-only cultures nor in co-cultures in which forskolin-induced progesterone production is always inhibited. Colforsin 55-64 interleukin 1 beta Rattus norvegicus 9-18 9330595-7 1997 Finally, IL-1 beta inhibited progesterone responses to forskolin and PGE2 in ovarian dispersates: an effect not observed in GL cell-only cultures nor in co-cultures in which forskolin-induced progesterone production is always inhibited. Dinoprostone 69-73 interleukin 1 beta Rattus norvegicus 9-18 9330595-7 1997 Finally, IL-1 beta inhibited progesterone responses to forskolin and PGE2 in ovarian dispersates: an effect not observed in GL cell-only cultures nor in co-cultures in which forskolin-induced progesterone production is always inhibited. Colforsin 174-183 interleukin 1 beta Rattus norvegicus 9-18 9330595-7 1997 Finally, IL-1 beta inhibited progesterone responses to forskolin and PGE2 in ovarian dispersates: an effect not observed in GL cell-only cultures nor in co-cultures in which forskolin-induced progesterone production is always inhibited. Progesterone 29-41 interleukin 1 beta Rattus norvegicus 9-18 9330595-9 1997 A comparison of the steroidogenic NO and PGE2 responses to IL-1 beta in the three culture models suggests that (i) the response to IL-1 beta observed in ovarian dispersates could be due to cytokine activation of resident and infiltrating macrophages or that the action of IL-1 beta requires some other heterologous cell-cell contact, and (ii) IL-1 beta acts indirectly on signal transduction pathways which stimulate steroidogenesis. Dinoprostone 41-45 interleukin 1 beta Rattus norvegicus 131-140 9330595-9 1997 A comparison of the steroidogenic NO and PGE2 responses to IL-1 beta in the three culture models suggests that (i) the response to IL-1 beta observed in ovarian dispersates could be due to cytokine activation of resident and infiltrating macrophages or that the action of IL-1 beta requires some other heterologous cell-cell contact, and (ii) IL-1 beta acts indirectly on signal transduction pathways which stimulate steroidogenesis. Dinoprostone 41-45 interleukin 1 beta Rattus norvegicus 131-140 9330595-9 1997 A comparison of the steroidogenic NO and PGE2 responses to IL-1 beta in the three culture models suggests that (i) the response to IL-1 beta observed in ovarian dispersates could be due to cytokine activation of resident and infiltrating macrophages or that the action of IL-1 beta requires some other heterologous cell-cell contact, and (ii) IL-1 beta acts indirectly on signal transduction pathways which stimulate steroidogenesis. Dinoprostone 41-45 interleukin 1 beta Rattus norvegicus 131-140 9330595-1 1997 It has been reported that interleukin (IL)-1 beta induces the synthesis of both nitric oxide (NO) and prostaglandin (PG)E2 in cultures of dispersed ovarian cells and exerts cytotoxic effects on these cells. Nitric Oxide 80-92 interleukin 1 beta Rattus norvegicus 26-49 9330595-1 1997 It has been reported that interleukin (IL)-1 beta induces the synthesis of both nitric oxide (NO) and prostaglandin (PG)E2 in cultures of dispersed ovarian cells and exerts cytotoxic effects on these cells. Dinoprostone 102-122 interleukin 1 beta Rattus norvegicus 26-49 9339386-4 1997 Western and Northern blot analyses of mesangial cell extracts reveal that the inhibition of IL-1 beta-induced nitrite formation by TGF-beta 2 is due to decreased iNOS protein and iNOS mRNA steady state levels. Nitrites 110-117 interleukin 1 beta Rattus norvegicus 92-101 9306258-3 1997 Primary osteoblast and ROS 17/2.8 cells released NO upon stimulation of interleukin-1 beta, tumour necrosis factor-alpha, and interferon-gamma. ros 23-26 interleukin 1 beta Rattus norvegicus 72-120 9307068-2 1997 DEX produced a dose-dependent inhibition of IL-1beta-induced leukocyte extravasation in the rat mesenteric vascular bed, with a calculated ED5o of 40 microg/kg and a maximal effect of 80-100% inhibition at 0.1 mg/kg. Dexamethasone 0-3 interleukin 1 beta Rattus norvegicus 44-52 9307068-2 1997 DEX produced a dose-dependent inhibition of IL-1beta-induced leukocyte extravasation in the rat mesenteric vascular bed, with a calculated ED5o of 40 microg/kg and a maximal effect of 80-100% inhibition at 0.1 mg/kg. ed5o 139-143 interleukin 1 beta Rattus norvegicus 44-52 9307068-3 1997 IL-1beta-induced cell adhesion to post-capillary venules was only partially inhibited by the steroid, with a calculated ED50 of 480 microg/kg and a maximal effect of 40-60% inhibition. Steroids 93-100 interleukin 1 beta Rattus norvegicus 0-8 9307068-6 1997 Administration for 5 days of a dose of 10 microg/kg DEX (which was inactive when given as a single injection) resulted again in a selective inhibition of IL-1beta-induced leukocyte emigration, without effect on cell adhesion. Dexamethasone 52-55 interleukin 1 beta Rattus norvegicus 154-162 9307243-0 1997 Exposure to alcohol in utero blunts splenic sympathetic neural response to endotoxin and interleukin-1beta in the rat. Alcohols 12-19 interleukin 1 beta Rattus norvegicus 89-106 9307243-1 1997 Systemic administration of endotoxin (LPS) or interleukin-1beta (IL-1) to prepubertal rats induced a marked increase in splenic but not cardiac norepinephrine (NE) turnover, an index of sympathetic neural activity. Norepinephrine 144-158 interleukin 1 beta Rattus norvegicus 46-63 9277562-2 1997 Pretreatment of rats intracerebroventricularly with 6-hydroxydopamine (6-OHDA, 100 or 200 micrograms/rat) significantly attenuated the increase in plasma IL-6 levels caused by IL-1 beta (2 micrograms/kg i.v.). Oxidopamine 52-69 interleukin 1 beta Rattus norvegicus 176-185 9650819-6 1997 IL-1beta, administered into both locations, induced a comparable suppression of motor activity, reduction in food and saccharine consumption, and loss of body weight. Saccharin 118-128 interleukin 1 beta Rattus norvegicus 0-8 9277562-2 1997 Pretreatment of rats intracerebroventricularly with 6-hydroxydopamine (6-OHDA, 100 or 200 micrograms/rat) significantly attenuated the increase in plasma IL-6 levels caused by IL-1 beta (2 micrograms/kg i.v.). Oxidopamine 71-77 interleukin 1 beta Rattus norvegicus 176-185 9277562-3 1997 A modest inhibition of the IL-1 beta-induced plasma IL-6 production was observed following pretreatment with prazosin (20 micrograms/rat i.c.v.) Prazosin 109-117 interleukin 1 beta Rattus norvegicus 27-36 9293396-2 1997 Since IL-1 beta is a potent neuro-endocrine-immuno modulator, alterations in the production of IL-1 beta by an exogenous factor, such as morphine or ethanol, may have deleterious effects on the system as a whole. Morphine 137-145 interleukin 1 beta Rattus norvegicus 95-104 9277562-6 1997 Adrenalectomy produced an augmented plasma IL-6 response to intravenous IL-1 beta, whereas chemical sympathectomy with intraperitoneal injection of 6-OHDA (50 or 100 mg/kg) decreased the IL-1 beta-induced plasma IL-6 levels. Oxidopamine 148-154 interleukin 1 beta Rattus norvegicus 187-196 9283695-7 1997 The tripeptide Lys-D-Pro-Val, which is known to antagonize IL-1 beta and prostaglandin E2 (PGE2) reversed mechanical hyperalgesia, as assessed by the PP test, and reduced significantly thermal hyperalgesia, as assessed by the HP and TF tests. tripeptide K-26 4-14 interleukin 1 beta Rattus norvegicus 59-68 9283695-7 1997 The tripeptide Lys-D-Pro-Val, which is known to antagonize IL-1 beta and prostaglandin E2 (PGE2) reversed mechanical hyperalgesia, as assessed by the PP test, and reduced significantly thermal hyperalgesia, as assessed by the HP and TF tests. lys-d-pro-val 15-28 interleukin 1 beta Rattus norvegicus 59-68 9245483-0 1997 Dexamethasone prevents interleukin-1beta-mediated inhibition of rat islet insulin secretion without decreasing nitric oxide production. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 23-40 9245483-3 1997 Incubation of newborn rat islets for 24 h in the presence of 150 pg/ml IL-1beta revealed that dexamethasone dose-dependently attenuated the inhibitory effect of IL-1beta on insulin release in response to a 2-h glucose challenge. Dexamethasone 94-107 interleukin 1 beta Rattus norvegicus 71-79 9245483-3 1997 Incubation of newborn rat islets for 24 h in the presence of 150 pg/ml IL-1beta revealed that dexamethasone dose-dependently attenuated the inhibitory effect of IL-1beta on insulin release in response to a 2-h glucose challenge. Dexamethasone 94-107 interleukin 1 beta Rattus norvegicus 161-169 9245483-3 1997 Incubation of newborn rat islets for 24 h in the presence of 150 pg/ml IL-1beta revealed that dexamethasone dose-dependently attenuated the inhibitory effect of IL-1beta on insulin release in response to a 2-h glucose challenge. Glucose 210-217 interleukin 1 beta Rattus norvegicus 71-79 9245483-3 1997 Incubation of newborn rat islets for 24 h in the presence of 150 pg/ml IL-1beta revealed that dexamethasone dose-dependently attenuated the inhibitory effect of IL-1beta on insulin release in response to a 2-h glucose challenge. Glucose 210-217 interleukin 1 beta Rattus norvegicus 161-169 9245483-5 1997 Dexamethasone (1 microM) increased the production of NO in IL-1beta-treated rat islets, as measured by the concentration of nitrite in the media. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 59-67 9245483-5 1997 Dexamethasone (1 microM) increased the production of NO in IL-1beta-treated rat islets, as measured by the concentration of nitrite in the media. Nitrites 124-131 interleukin 1 beta Rattus norvegicus 59-67 9245483-6 1997 However, 1-5 microM dexamethasone inhibited IL-1beta-induced NO production by RIN cells. Dexamethasone 20-33 interleukin 1 beta Rattus norvegicus 44-52 9245483-8 1997 We conclude that dexamethasone partially protects against IL-1beta-induced inhibition of rat islet insulin secretion, an effect which is not mediated through modulation of the NO pathway. Dexamethasone 17-30 interleukin 1 beta Rattus norvegicus 58-66 9262235-9 1997 Furthermore, IL-1beta mRNA was detected at 6 hours in dbcAMP-treated SchC, preceding the dbcAMP-induced C3 expression by 18 hours. Bucladesine 54-60 interleukin 1 beta Rattus norvegicus 13-21 9262235-11 1997 This suggests that dbcAMP-induced synthesis of IL-1beta mediates the C3 production by SchC in an autocrine/paracrine fashion by binding to a functional IL-1 receptor expressed on the surface of SchC. Bucladesine 19-25 interleukin 1 beta Rattus norvegicus 47-55 9293396-2 1997 Since IL-1 beta is a potent neuro-endocrine-immuno modulator, alterations in the production of IL-1 beta by an exogenous factor, such as morphine or ethanol, may have deleterious effects on the system as a whole. Ethanol 149-156 interleukin 1 beta Rattus norvegicus 95-104 9231726-2 1997 In these cells, simultaneous addition of endothelin (ET) decreased iNOS expression and nitrite accumulation induced by TNF-alpha/IL-1beta. Nitrites 87-94 interleukin 1 beta Rattus norvegicus 129-137 9231726-1 1997 In primary cultured rat glial cells, a combination of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) stimulates production of nitrite via expression of the inducible form of nitric oxide synthase (iNOS). Nitrites 183-190 interleukin 1 beta Rattus norvegicus 129-146 9231726-6 1997 Furthermore, cyclic AMP-elevating agents (dibutyryl cyclic AMP and forskolin) inhibited TNF-alpha/IL-1beta-induced and LPS-induced iNOS expression and nitrite accumulation. Cyclic AMP 13-23 interleukin 1 beta Rattus norvegicus 98-106 9231726-1 1997 In primary cultured rat glial cells, a combination of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) stimulates production of nitrite via expression of the inducible form of nitric oxide synthase (iNOS). Nitrites 183-190 interleukin 1 beta Rattus norvegicus 148-156 9231726-6 1997 Furthermore, cyclic AMP-elevating agents (dibutyryl cyclic AMP and forskolin) inhibited TNF-alpha/IL-1beta-induced and LPS-induced iNOS expression and nitrite accumulation. Bucladesine 42-62 interleukin 1 beta Rattus norvegicus 98-106 9231747-6 1997 The effects of IL-1beta but not LPS in the mixed primary culture of diencephalon were canceled by a prior exposure to cytosine-beta-D-arabinofuranoside. Cytarabine 118-151 interleukin 1 beta Rattus norvegicus 15-23 9231726-6 1997 Furthermore, cyclic AMP-elevating agents (dibutyryl cyclic AMP and forskolin) inhibited TNF-alpha/IL-1beta-induced and LPS-induced iNOS expression and nitrite accumulation. Colforsin 67-76 interleukin 1 beta Rattus norvegicus 98-106 9228043-8 1997 IL-1beta increases both acid and neutral ceramidase activities, which appear to be regulated by tyrosine phosphorylation because pretreatment of hepatocytes with sodium vanadate increases (and 25 microM genistein reduces) the basal and IL-1beta-stimulated ceramidase activities. Tyrosine 96-104 interleukin 1 beta Rattus norvegicus 0-8 9231653-13 1997 IL-1beta caused appreciable damage to mtDNA, and this damage was reduced in mtDNA from cultures treated with IL-1beta and aminoguanidine. pimagedine 122-136 interleukin 1 beta Rattus norvegicus 0-8 9228043-8 1997 IL-1beta increases both acid and neutral ceramidase activities, which appear to be regulated by tyrosine phosphorylation because pretreatment of hepatocytes with sodium vanadate increases (and 25 microM genistein reduces) the basal and IL-1beta-stimulated ceramidase activities. Tyrosine 96-104 interleukin 1 beta Rattus norvegicus 236-244 9228043-8 1997 IL-1beta increases both acid and neutral ceramidase activities, which appear to be regulated by tyrosine phosphorylation because pretreatment of hepatocytes with sodium vanadate increases (and 25 microM genistein reduces) the basal and IL-1beta-stimulated ceramidase activities. Vanadates 162-177 interleukin 1 beta Rattus norvegicus 0-8 9228043-8 1997 IL-1beta increases both acid and neutral ceramidase activities, which appear to be regulated by tyrosine phosphorylation because pretreatment of hepatocytes with sodium vanadate increases (and 25 microM genistein reduces) the basal and IL-1beta-stimulated ceramidase activities. Vanadates 162-177 interleukin 1 beta Rattus norvegicus 236-244 9228043-8 1997 IL-1beta increases both acid and neutral ceramidase activities, which appear to be regulated by tyrosine phosphorylation because pretreatment of hepatocytes with sodium vanadate increases (and 25 microM genistein reduces) the basal and IL-1beta-stimulated ceramidase activities. Genistein 203-212 interleukin 1 beta Rattus norvegicus 0-8 9228043-8 1997 IL-1beta increases both acid and neutral ceramidase activities, which appear to be regulated by tyrosine phosphorylation because pretreatment of hepatocytes with sodium vanadate increases (and 25 microM genistein reduces) the basal and IL-1beta-stimulated ceramidase activities. Genistein 203-212 interleukin 1 beta Rattus norvegicus 236-244 9228043-9 1997 Since these findings suggested that sphingosine (and, possibly, subsequent metabolites) is the primary mediator of the down-regulation of CYP2C11 by IL-1beta, the effects of exogenous sphingosine and C2-Cer on expression of this gene were compared. Sphingosine 36-47 interleukin 1 beta Rattus norvegicus 149-157 9228043-12 1997 From these observations we conclude that sphingosine, possibly via sphingosine 1-phosphate, is a mediator of the regulation of CYP2C11 by IL-1beta in rat hepatocytes and that ceramidase activation provides a "switch" that determines which sphingolipids are elevated by this cytokine to produce multiple intracellular responses. Sphingosine 41-52 interleukin 1 beta Rattus norvegicus 138-146 9228043-12 1997 From these observations we conclude that sphingosine, possibly via sphingosine 1-phosphate, is a mediator of the regulation of CYP2C11 by IL-1beta in rat hepatocytes and that ceramidase activation provides a "switch" that determines which sphingolipids are elevated by this cytokine to produce multiple intracellular responses. sphingosine 1-phosphate 67-90 interleukin 1 beta Rattus norvegicus 138-146 9252020-0 1997 Effects of interleukin-1beta and mild stress on alterations of norepinephrine, dopamine and serotonin neurotransmission: a regional microdialysis study. Serotonin 92-101 interleukin 1 beta Rattus norvegicus 11-28 9253947-10 1997 Addition of L-NMMA (1 mM) during the 24 h treatment prevented NO production and preserved the sodium nitroprusside-induced cGMP generation by interleukin-1beta. omega-N-Methylarginine 12-18 interleukin 1 beta Rattus norvegicus 142-159 9253947-10 1997 Addition of L-NMMA (1 mM) during the 24 h treatment prevented NO production and preserved the sodium nitroprusside-induced cGMP generation by interleukin-1beta. Nitroprusside 94-114 interleukin 1 beta Rattus norvegicus 142-159 9253947-10 1997 Addition of L-NMMA (1 mM) during the 24 h treatment prevented NO production and preserved the sodium nitroprusside-induced cGMP generation by interleukin-1beta. Cyclic GMP 123-127 interleukin 1 beta Rattus norvegicus 142-159 9253947-11 1997 The 24 h interleukin-1beta treatment increased the threshold concentration of KCl needed to induce contraction without changing the maximum contraction. Potassium Chloride 78-81 interleukin 1 beta Rattus norvegicus 9-26 9253947-12 1997 In the presence of 25.4 mM KCl or the non-selective K+ channel inhibitor, tetraethylammonium, the inhibitory effect of the 24-h interleukin-1beta treatment on phenylephrine-induced contraction was restored. Potassium Chloride 27-30 interleukin 1 beta Rattus norvegicus 128-145 9253947-12 1997 In the presence of 25.4 mM KCl or the non-selective K+ channel inhibitor, tetraethylammonium, the inhibitory effect of the 24-h interleukin-1beta treatment on phenylephrine-induced contraction was restored. Tetraethylammonium 74-92 interleukin 1 beta Rattus norvegicus 128-145 9253947-12 1997 In the presence of 25.4 mM KCl or the non-selective K+ channel inhibitor, tetraethylammonium, the inhibitory effect of the 24-h interleukin-1beta treatment on phenylephrine-induced contraction was restored. Phenylephrine 159-172 interleukin 1 beta Rattus norvegicus 128-145 9253947-14 1997 After a 6-h treatment with interleukin-1beta, the NO/cyclic GMP system is activated. Cyclic GMP 53-63 interleukin 1 beta Rattus norvegicus 27-44 9253947-15 1997 After a 24-h interleukin-1beta treatment, in contrast, the NO/cyclic GMP system may be desensitized and the contraction of vascular smooth muscle is inhibited by another mechanism, possibly membrane hyperpolarization. Cyclic GMP 62-72 interleukin 1 beta Rattus norvegicus 13-30 9252020-1 1997 The effects of systemically administered interleukin-1beta (1.0 microg) on in vivo variations of monoamines was assessed in several brain regions. monoamines 97-107 interleukin 1 beta Rattus norvegicus 41-58 9302361-10 1997 CONCLUSIONS: These results indicate that adenosine acts on A2 receptors and augments NO synthesis in interleukin-1 beta-stimulated vascular smooth muscle cells, at least partially through a cAMP-dependent pathway. Adenosine 41-50 interleukin 1 beta Rattus norvegicus 101-119 9302361-10 1997 CONCLUSIONS: These results indicate that adenosine acts on A2 receptors and augments NO synthesis in interleukin-1 beta-stimulated vascular smooth muscle cells, at least partially through a cAMP-dependent pathway. Cyclic AMP 190-194 interleukin 1 beta Rattus norvegicus 101-119 9253947-0 1997 Interleukin-1beta-induced, nitric oxide-dependent and -independent inhibition of vascular smooth muscle contraction. Nitric Oxide 27-39 interleukin 1 beta Rattus norvegicus 0-17 9253947-3 1997 After treatment of the rat aorta with interleukin-1beta (20 ng/ml) for 6 h, the cyclic GMP content increased and the contraction induced by phenylephrine (1 microM) was partially inhibited. Cyclic GMP 80-90 interleukin 1 beta Rattus norvegicus 38-55 9253947-3 1997 After treatment of the rat aorta with interleukin-1beta (20 ng/ml) for 6 h, the cyclic GMP content increased and the contraction induced by phenylephrine (1 microM) was partially inhibited. Phenylephrine 140-153 interleukin 1 beta Rattus norvegicus 38-55 9253947-4 1997 An inhibitor of nitric oxide (NO) synthase, N(G)-monomethyl-L-arginine (L-NMMA, 100 microM), prevented the inhibitory effect of interleukin-1beta. Nitric Oxide 16-28 interleukin 1 beta Rattus norvegicus 128-145 9253947-4 1997 An inhibitor of nitric oxide (NO) synthase, N(G)-monomethyl-L-arginine (L-NMMA, 100 microM), prevented the inhibitory effect of interleukin-1beta. omega-N-Methylarginine 44-70 interleukin 1 beta Rattus norvegicus 128-145 9253947-4 1997 An inhibitor of nitric oxide (NO) synthase, N(G)-monomethyl-L-arginine (L-NMMA, 100 microM), prevented the inhibitory effect of interleukin-1beta. omega-N-Methylarginine 72-78 interleukin 1 beta Rattus norvegicus 128-145 9253947-5 1997 After treatment with interleukin-1beta for 24 h, the phenylephrine-induced contraction was inhibited more strongly. Phenylephrine 53-66 interleukin 1 beta Rattus norvegicus 21-38 9253947-7 1997 After treatment with interleukin-1beta for 12 or 24 h, the cyclic GMP content increased but to a level lower than that obtained with a 6-h treatment. Cyclic GMP 59-69 interleukin 1 beta Rattus norvegicus 21-38 9253947-8 1997 The effects of sodium nitroprusside (1 microM) to inhibit the phenylephrine-induced contraction and to increase the cyclic GMP content were markedly suppressed by the 24-h interleukin-1beta treatment. Nitroprusside 15-35 interleukin 1 beta Rattus norvegicus 172-189 9253947-8 1997 The effects of sodium nitroprusside (1 microM) to inhibit the phenylephrine-induced contraction and to increase the cyclic GMP content were markedly suppressed by the 24-h interleukin-1beta treatment. Phenylephrine 62-75 interleukin 1 beta Rattus norvegicus 172-189 9253947-8 1997 The effects of sodium nitroprusside (1 microM) to inhibit the phenylephrine-induced contraction and to increase the cyclic GMP content were markedly suppressed by the 24-h interleukin-1beta treatment. Cyclic GMP 116-126 interleukin 1 beta Rattus norvegicus 172-189 9249475-2 1997 Incubation of cultures with interleukin-1 beta (10 ng/ml) for 24 h caused a significant increase in nitrite production. Nitrites 100-107 interleukin 1 beta Rattus norvegicus 28-46 9249475-3 1997 The interleukin-1 beta-induced nitrite production by cardiac myocytes was significantly increased by adenosine or its stable analog 2-chloroadenosine in a dose-dependent manner (10(-7)-10(-4) M). Nitrites 31-38 interleukin 1 beta Rattus norvegicus 4-22 9249475-3 1997 The interleukin-1 beta-induced nitrite production by cardiac myocytes was significantly increased by adenosine or its stable analog 2-chloroadenosine in a dose-dependent manner (10(-7)-10(-4) M). Adenosine 101-110 interleukin 1 beta Rattus norvegicus 4-22 9249475-3 1997 The interleukin-1 beta-induced nitrite production by cardiac myocytes was significantly increased by adenosine or its stable analog 2-chloroadenosine in a dose-dependent manner (10(-7)-10(-4) M). 2-Chloroadenosine 132-149 interleukin 1 beta Rattus norvegicus 4-22 9249475-5 1997 The 2-chloroadenosine-induced nitrite production by interleukin-1 beta-stimulated cells was accompanied by inducible NO synthase mRNA and protein accumulation. 2-Chloroadenosine 4-21 interleukin 1 beta Rattus norvegicus 52-70 9249475-5 1997 The 2-chloroadenosine-induced nitrite production by interleukin-1 beta-stimulated cells was accompanied by inducible NO synthase mRNA and protein accumulation. Nitrites 30-37 interleukin 1 beta Rattus norvegicus 52-70 9249475-6 1997 In the presence of N6, 2"-O-dibutyryladenosine 3",5"-cyclic monophosphate (cAMP) (10(-3) M) or isoproterenol (10(-5) M), interleukin-1 beta-induced nitrite accumulation was further increased, but the effect of 2-chloroadenosine was not additive or synergistic. Bucladesine 19-73 interleukin 1 beta Rattus norvegicus 121-139 9249475-8 1997 These results indicate that adenosine acts on A2 receptors and augments NO synthesis in interleukin-1 beta-stimulated cardiac myocytes, at least partially through a cAMP-dependent pathway. Adenosine 28-37 interleukin 1 beta Rattus norvegicus 88-106 9249475-8 1997 These results indicate that adenosine acts on A2 receptors and augments NO synthesis in interleukin-1 beta-stimulated cardiac myocytes, at least partially through a cAMP-dependent pathway. Cyclic AMP 165-169 interleukin 1 beta Rattus norvegicus 88-106 9252556-5 1997 IL-1 beta effect was dependent on protein synthesis, was partially prevented with indomethacin, and was totally prevented with dexamethasone. Indomethacin 82-94 interleukin 1 beta Rattus norvegicus 0-9 9252556-5 1997 IL-1 beta effect was dependent on protein synthesis, was partially prevented with indomethacin, and was totally prevented with dexamethasone. Dexamethasone 127-140 interleukin 1 beta Rattus norvegicus 0-9 9302361-4 1997 RESULTS: Incubation of cultures with interleukin-1 beta (10 ng/ml) for 24 h caused a significant increase in nitrite production. Nitrites 109-116 interleukin 1 beta Rattus norvegicus 37-55 9302361-5 1997 The interleukin-1 beta-induced nitrite production by vascular smooth muscle cells was significantly increased by adenosine or its stable analogue, 2-chloroadenosine, in a dose-dependent manner. Nitrites 31-38 interleukin 1 beta Rattus norvegicus 4-22 9302361-5 1997 The interleukin-1 beta-induced nitrite production by vascular smooth muscle cells was significantly increased by adenosine or its stable analogue, 2-chloroadenosine, in a dose-dependent manner. Adenosine 113-122 interleukin 1 beta Rattus norvegicus 4-22 9302361-5 1997 The interleukin-1 beta-induced nitrite production by vascular smooth muscle cells was significantly increased by adenosine or its stable analogue, 2-chloroadenosine, in a dose-dependent manner. 2-Chloroadenosine 147-164 interleukin 1 beta Rattus norvegicus 4-22 9302361-7 1997 The 2-chloroadenosine-mediated nitrite production by interleukin-1 beta-stimulated cells was accompanied by increased inducible NO synthase mRNA accumulation. 2-Chloroadenosine 4-21 interleukin 1 beta Rattus norvegicus 53-71 9302361-7 1997 The 2-chloroadenosine-mediated nitrite production by interleukin-1 beta-stimulated cells was accompanied by increased inducible NO synthase mRNA accumulation. Nitrites 31-38 interleukin 1 beta Rattus norvegicus 53-71 9302361-8 1997 In the presence of dibutyryl-cAMP (1 mM), interleukin-1 beta-induced nitrite accumulation was further increased, but the effect of 2-chloroadenosine was not additive or synergistic. Bucladesine 19-33 interleukin 1 beta Rattus norvegicus 42-60 9302361-8 1997 In the presence of dibutyryl-cAMP (1 mM), interleukin-1 beta-induced nitrite accumulation was further increased, but the effect of 2-chloroadenosine was not additive or synergistic. Nitrites 69-76 interleukin 1 beta Rattus norvegicus 42-60 9202204-0 1997 Interleukin (IL)-1beta increases glucose uptake and induces glycolysis in aerobically cultured rat ovarian cells: evidence that IL-1beta may mediate the gonadotropin-induced midcycle metabolic shift. Glucose 33-40 interleukin 1 beta Rattus norvegicus 0-22 9202204-0 1997 Interleukin (IL)-1beta increases glucose uptake and induces glycolysis in aerobically cultured rat ovarian cells: evidence that IL-1beta may mediate the gonadotropin-induced midcycle metabolic shift. Glucose 33-40 interleukin 1 beta Rattus norvegicus 128-136 9202213-9 1997 It has been previously reported that nicotinamide prevents IL-1beta-induced IRF-1 expression in rat pancreatic islets. Niacinamide 37-49 interleukin 1 beta Rattus norvegicus 59-67 9202204-1 1997 This communication explores the possibility that interleukin (IL)-1beta, a putative intermediary in the ovulatory process, may take part in the gonadotropin-driven midcycle diversion of ovarian carbohydrate metabolism toward glycolysis. Carbohydrates 194-206 interleukin 1 beta Rattus norvegicus 49-71 9202204-2 1997 We examined the effect of treatment with IL-1beta on glucose metabolism in aerobically cultured whole ovarian dispersates from immature rats. Glucose 53-60 interleukin 1 beta Rattus norvegicus 41-49 9202204-3 1997 Treatment with IL-1beta increased cellular glucose consumption/uptake, stimulated extracellular lactate accumulation and media acidification, and decreased extracellular pyruvate accumulation in a receptor-mediated, time-, dose- and cell density-dependent manner. Glucose 43-50 interleukin 1 beta Rattus norvegicus 15-23 9202204-3 1997 Treatment with IL-1beta increased cellular glucose consumption/uptake, stimulated extracellular lactate accumulation and media acidification, and decreased extracellular pyruvate accumulation in a receptor-mediated, time-, dose- and cell density-dependent manner. Lactic Acid 96-103 interleukin 1 beta Rattus norvegicus 15-23 9202204-5 1997 The IL-1beta effect was also (1) apparent over a broad range of glucose concentrations, inclusive of the putative physiological window; (2) relatively specific, because tumor necrosis factor-alpha and insulin were inactive; (3) contingent upon cell-cell cooperation (4) and reliant on de novo protein synthesis. Glucose 64-71 interleukin 1 beta Rattus norvegicus 4-12 9202204-6 1997 Comparison of the molar ratios of lactate accumulation to glucose consumption in IL-1beta-replete vs. IL-1beta-deplete cultures suggests that IL-beta promotes the conversion of all available glucose to lactate but that other substrates for lactate production may also exist. Lactic Acid 34-41 interleukin 1 beta Rattus norvegicus 81-89 9202204-6 1997 Comparison of the molar ratios of lactate accumulation to glucose consumption in IL-1beta-replete vs. IL-1beta-deplete cultures suggests that IL-beta promotes the conversion of all available glucose to lactate but that other substrates for lactate production may also exist. Glucose 58-65 interleukin 1 beta Rattus norvegicus 81-89 9202204-6 1997 Comparison of the molar ratios of lactate accumulation to glucose consumption in IL-1beta-replete vs. IL-1beta-deplete cultures suggests that IL-beta promotes the conversion of all available glucose to lactate but that other substrates for lactate production may also exist. Glucose 191-198 interleukin 1 beta Rattus norvegicus 81-89 9202204-9 1997 Subject to the limitations of the in vitro paradigm, our data also suggest that IL-1beta may mediate the gonadotropin-associated midcycle shift in ovarian carbohydrate metabolism. Carbohydrates 155-167 interleukin 1 beta Rattus norvegicus 80-88 9202204-10 1997 By converting the somatic ovarian cells into a glucose-consuming glycolytic machinery, IL-1beta may establish glycolysis as the main energy source of the relatively hypoxic preovulatory follicle and the resultant cumulus-oocyte complex. Glucose 47-54 interleukin 1 beta Rattus norvegicus 87-95 9214451-9 1997 Exogenous IL-1beta, administered parenterally to a group of rats at 0 and 12 hours after partial hepatectomy significantly reduced the incorporation of the thymidine analogue, bromodeoxyuridine (BrdU), into hepatocytes at 18 hours. Thymidine 156-165 interleukin 1 beta Rattus norvegicus 10-18 9214451-9 1997 Exogenous IL-1beta, administered parenterally to a group of rats at 0 and 12 hours after partial hepatectomy significantly reduced the incorporation of the thymidine analogue, bromodeoxyuridine (BrdU), into hepatocytes at 18 hours. Bromodeoxyuridine 176-193 interleukin 1 beta Rattus norvegicus 10-18 9214451-9 1997 Exogenous IL-1beta, administered parenterally to a group of rats at 0 and 12 hours after partial hepatectomy significantly reduced the incorporation of the thymidine analogue, bromodeoxyuridine (BrdU), into hepatocytes at 18 hours. Bromodeoxyuridine 195-199 interleukin 1 beta Rattus norvegicus 10-18 9214454-2 1997 The proinflammatory cytokine, interleukin-6 (IL-6), which in the liver together with IL-1beta and tumor necrosis factor alpha triggers the acute-phase response, had been shown to attenuate the glucagon-induced increase in PCK gene transcription, messenger (mRNA) levels, and enzyme activity. Glucagon 193-201 interleukin 1 beta Rattus norvegicus 85-93 18975157-0 1997 Suppressive effects of triterpenoids on CINC-1 induction in interleukin-1beta-stimulated rat fibroblast NRK-49F cells. triterpenoids 23-36 interleukin 1 beta Rattus norvegicus 60-77 9227638-9 1997 Treatment of EC with interleukin-1 beta (IL-1 beta) for 24 h prior to coincubation with VSMC enhanced the protective effect of EC. vsmc 88-92 interleukin 1 beta Rattus norvegicus 21-39 9227638-9 1997 Treatment of EC with interleukin-1 beta (IL-1 beta) for 24 h prior to coincubation with VSMC enhanced the protective effect of EC. vsmc 88-92 interleukin 1 beta Rattus norvegicus 41-50 9227638-10 1997 IL-1 beta-induced protection was reversed with L-NNA. Nitroarginine 47-52 interleukin 1 beta Rattus norvegicus 0-9 9195908-0 1997 Modulation of glutathione S-transferase subunits A2, M1, and P1 expression by interleukin-1beta in rat hepatocytes in primary culture. Glutathione 14-25 interleukin 1 beta Rattus norvegicus 78-95 9256165-3 1997 In leukocytes, sulfasalazine and its analogue, CL 42A, inhibited the formation of leukotrienes and possibly of the second messenger compounds at the level of phospholipase C. Partial inhibition of interleukin-lbeta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha) was also found. Sulfasalazine 15-28 interleukin 1 beta Rattus norvegicus 216-224 9256165-3 1997 In leukocytes, sulfasalazine and its analogue, CL 42A, inhibited the formation of leukotrienes and possibly of the second messenger compounds at the level of phospholipase C. Partial inhibition of interleukin-lbeta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha) was also found. CL 42A 47-53 interleukin 1 beta Rattus norvegicus 216-224 9227535-0 1997 Involvement of ceramide in inhibitory effect of IL-1 beta on L-type Ca2+ current in adult rat ventricular myocytes. Ceramides 15-23 interleukin 1 beta Rattus norvegicus 48-57 9227535-2 1997 Because ceramide has been suggested to mediate many biological effects of IL-1 beta, we examined whether ceramide was involved in the IL-1 beta-induced suppression of ICa,L in adult rat ventricular myocytes. isocyanic acid 167-170 interleukin 1 beta Rattus norvegicus 134-143 9227535-3 1997 Exposure of myocytes to 5 ng/ml IL-1 beta elicited a 140% increase in ceramide production within 2 min, as measured with 32P phosphorylation. Ceramides 70-78 interleukin 1 beta Rattus norvegicus 32-41 9227535-3 1997 Exposure of myocytes to 5 ng/ml IL-1 beta elicited a 140% increase in ceramide production within 2 min, as measured with 32P phosphorylation. Phosphorus-32 121-124 interleukin 1 beta Rattus norvegicus 32-41 9227535-7 1997 At submaximal concentrations, effects of C2 ceramide and IL-1 beta on ICa,L were additive and saturable. isocyanic acid 70-73 interleukin 1 beta Rattus norvegicus 57-66 9227535-9 1997 These results suggest that ceramide mediates IL-1 beta-induced suppression of cardiac ICa,L. Ceramides 27-35 interleukin 1 beta Rattus norvegicus 45-54 18975157-4 1997 Steroidal anti-inflammatory drugs including dexamethasone and prednisolone exhibited potent suppressive effects on IL-1beta-induced CINC-1 production. Dexamethasone 44-57 interleukin 1 beta Rattus norvegicus 115-123 18975157-4 1997 Steroidal anti-inflammatory drugs including dexamethasone and prednisolone exhibited potent suppressive effects on IL-1beta-induced CINC-1 production. Prednisolone 62-74 interleukin 1 beta Rattus norvegicus 115-123 18975157-6 1997 The suppressive potency of acacigenin B on IL-1beta-induced CINC-1 production was about 10-fold less than that of the steroidal anti-inflammatory drugs. Acacigenin B 27-39 interleukin 1 beta Rattus norvegicus 43-51 9186870-10 1997 Northern blot analysis of whole kidney RNA demonstrated an 830% increase in IL-1 beta mRNA expression in saline controls compared to normal rat kidney. Sodium Chloride 105-111 interleukin 1 beta Rattus norvegicus 76-85 9210623-9 1997 The concentration of nitrites in the hepatocyte supernatant rose from 14.70+/-3.55 micromol x l(-1) to 150.50+/-45.55 micromol x l(-1) in the presence of a combination of interleukin-1beta, TNF alpha and interferon gamma. Nitrites 21-29 interleukin 1 beta Rattus norvegicus 171-188 9184648-8 1997 Macrophages from Linomide-treated EAN rats showed decreased IL-1 beta, TNF-alpha and IL-6 mRNA expression in response to IFN-gamma and LPS. roquinimex 17-25 interleukin 1 beta Rattus norvegicus 60-69 9208149-0 1997 Suppression by cyclosporin A of interleukin 1 beta-induced expression of group II phospholipase A2 in rat renal mesangial cells. Cyclosporine 15-28 interleukin 1 beta Rattus norvegicus 32-50 9208149-7 1997 Incubation of mesangial cells with cyclosporin A inhibited IL-1 beta-induced PLA2 section in a dose-dependent fashion, with an IC50 value of 4.3 microM. Cyclosporine 35-48 interleukin 1 beta Rattus norvegicus 59-68 9208149-18 1997 The data presented in this study strongly suggest that the cellular mechanism involved in the IL1 beta-dependent transcriptional upregulation of the PLA2 gene in mesangial cells is a target for the action of cyclosporin A. Cyclosporine 208-221 interleukin 1 beta Rattus norvegicus 94-102 9185761-2 1997 IL-1beta produces nitric oxide (NO) in vascular smooth muscle cells and relaxes vascular smooth muscle via cyclic guanosine 3",5"-monophosphate (cGMP). Nitric Oxide 18-30 interleukin 1 beta Rattus norvegicus 0-8 9185761-2 1997 IL-1beta produces nitric oxide (NO) in vascular smooth muscle cells and relaxes vascular smooth muscle via cyclic guanosine 3",5"-monophosphate (cGMP). Cyclic GMP 107-143 interleukin 1 beta Rattus norvegicus 0-8 9185761-2 1997 IL-1beta produces nitric oxide (NO) in vascular smooth muscle cells and relaxes vascular smooth muscle via cyclic guanosine 3",5"-monophosphate (cGMP). Cyclic GMP 145-149 interleukin 1 beta Rattus norvegicus 0-8 9185761-9 1997 In Ito cells, immunofluorescence of iNOS was observed, and fluorescent intensity of cGMP increased after addition of IL-1beta. Cyclic GMP 84-88 interleukin 1 beta Rattus norvegicus 117-125 9185761-10 1997 Intracellular cGMP concentration increased dose-dependently after addition of IL-1beta. Cyclic GMP 14-18 interleukin 1 beta Rattus norvegicus 78-86 9185761-12 1997 Relaxation of Ito cells by IL-1beta treatment was inhibited by L-NMMA in a dose-dependent manner, but was enhanced by SNAP. omega-N-Methylarginine 63-69 interleukin 1 beta Rattus norvegicus 27-35 9185761-13 1997 These results indicate that IL-1beta produces NO in cultured Ito cells and relaxes the cells via cGMP. Cyclic GMP 97-101 interleukin 1 beta Rattus norvegicus 28-36 9218182-0 1997 Arginine vasopressin inhibits interleukin-1 beta-stimulated nitric oxide and cyclic guanosine monophosphate production via the V1 receptor in cultured rat vascular smooth muscle cells. Nitric Oxide 60-72 interleukin 1 beta Rattus norvegicus 30-48 9218182-0 1997 Arginine vasopressin inhibits interleukin-1 beta-stimulated nitric oxide and cyclic guanosine monophosphate production via the V1 receptor in cultured rat vascular smooth muscle cells. Cyclic GMP 77-107 interleukin 1 beta Rattus norvegicus 30-48 9218182-9 1997 RESULTS: AVP inhibited IL-1 beta-induced nitrite production in a dose- and time-dependent manner with concomitant changes in intracellular cGMP contents. Nitrites 41-48 interleukin 1 beta Rattus norvegicus 23-32 9218182-14 1997 CONCLUSION: It is suggested that AVP inhibits IL-1 beta-induced NO and cGMP production via the V1 receptor but not via the OXT receptor in VSMC. Cyclic GMP 71-75 interleukin 1 beta Rattus norvegicus 46-55 9153192-3 1997 Pretreatment of cells with GGTI-298 caused a superinduction of NOS-2 by IL-1beta. GGTI 298 27-35 interleukin 1 beta Rattus norvegicus 72-80 9153192-4 1997 RPASMC treated with GGTI-298 (10 microM) prior to IL-1beta (10 ng/ml) expressed levels of NOS-2 protein five times higher than those exposed to IL-1beta alone. GGTI 298 20-28 interleukin 1 beta Rattus norvegicus 50-58 9153192-4 1997 RPASMC treated with GGTI-298 (10 microM) prior to IL-1beta (10 ng/ml) expressed levels of NOS-2 protein five times higher than those exposed to IL-1beta alone. GGTI 298 20-28 interleukin 1 beta Rattus norvegicus 144-152 9153221-6 1997 iNOS expression and nitrite production by rat islets in response to 150 units/ml rat IFN-gamma and 0.1 unit/ml IL-1beta are correlated with an inhibition of insulin secretion and islet degeneration that are prevented by the iNOS inhibitor aminoguanidine. pimagedine 239-253 interleukin 1 beta Rattus norvegicus 111-119 9153192-5 1997 This superinduction of NOS-2 protein by pretreatment with GGTI-298 resulted in nitrite concentrations in the medium that were 5-fold higher at 10 ng/ml IL-1beta and 10-fold higher at 1 ng/ml IL-1beta. Nitrites 79-86 interleukin 1 beta Rattus norvegicus 152-160 9153221-8 1997 Last, cellular damage during physical dispersion of islets results in the release of sufficient amounts of IL-1beta to induce iNOS expression and nitrite production in the presence of exogenously added rat IFN-gamma. Nitrites 146-153 interleukin 1 beta Rattus norvegicus 107-115 9153221-1 1997 The purpose of this study was to evaluate the effects of interferon-gamma (IFN-gamma) alone and in combination with interleukin 1beta (IL-1beta) on inducible nitric-oxide synthase (iNOS) mRNA and protein expression, nitrite production, and insulin secretion by islets of Langerhans. Nitrites 216-223 interleukin 1 beta Rattus norvegicus 135-143 9153221-2 1997 Treatment of rat islets with IL-1beta results in a concentration-dependent increase in the production of nitrite that is maximal at 5 units/ml. Nitrites 105-112 interleukin 1 beta Rattus norvegicus 29-37 9153221-9 1997 The cellular source of IL-1beta under these conditions is believed to be resident islet macrophages as depletion of macrophages prior to dispersion prevents IFN-gamma-induced iNOS expression and nitrite formation by dispersed islet cells. Nitrites 195-202 interleukin 1 beta Rattus norvegicus 23-31 9153221-10 1997 These studies show that the T-lymphocyte cytokine, IFN-gamma, increases the sensitivity of rat islets to the effects of IL-1beta on iNOS expression and nitrite production by 10-fold, in part, through the stabilization of iNOS mRNA. Nitrites 152-159 interleukin 1 beta Rattus norvegicus 120-128 9153221-6 1997 iNOS expression and nitrite production by rat islets in response to 150 units/ml rat IFN-gamma and 0.1 unit/ml IL-1beta are correlated with an inhibition of insulin secretion and islet degeneration that are prevented by the iNOS inhibitor aminoguanidine. Nitrites 20-27 interleukin 1 beta Rattus norvegicus 111-119 9153192-7 1997 In contrast, treatment of cells with the inhibitor of protein farnesylation, FTI-277 (10 microM), blocked IL-1beta-induced NOS-2 expression at mRNA and protein levels. FTI 277 77-84 interleukin 1 beta Rattus norvegicus 106-114 9179586-0 1997 Roles of purine nucleotides and adenosine in enhancing NOS II gene expression in interleukin-1 beta-stimulated rat vascular smooth muscle cells. purine 9-15 interleukin 1 beta Rattus norvegicus 81-99 9177260-6 1997 These data indicate that BZT-mediated oxidative stress increases IL-1beta induced iNOS gene transcription and iNOS promoter activity. bzt 25-28 interleukin 1 beta Rattus norvegicus 65-73 9176234-6 1997 Induction of MnSOD by IL-1 beta was eliminated by actinomycin but not by cycloheximide, implicating a requirement for de novo transcription. Dactinomycin 50-61 interleukin 1 beta Rattus norvegicus 22-31 9176234-8 1997 Induction of MnSOD by IL-1 beta and other inflammatory mediators may serve as a protective mechanism to reduce oxygen free radical- and nitric oxide-mediated cell damage during inflammation. oxygen free radical 111-130 interleukin 1 beta Rattus norvegicus 22-31 9176234-8 1997 Induction of MnSOD by IL-1 beta and other inflammatory mediators may serve as a protective mechanism to reduce oxygen free radical- and nitric oxide-mediated cell damage during inflammation. Nitric Oxide 136-148 interleukin 1 beta Rattus norvegicus 22-31 9191258-0 1997 Ganglioside GM1 potentiates the effect of IL-1 beta on neutral sphingomyelinase activity in rat brain synaptosomes. Gangliosides 0-11 interleukin 1 beta Rattus norvegicus 42-51 9191258-0 1997 Ganglioside GM1 potentiates the effect of IL-1 beta on neutral sphingomyelinase activity in rat brain synaptosomes. G(M1) Ganglioside 12-15 interleukin 1 beta Rattus norvegicus 42-51 9179586-0 1997 Roles of purine nucleotides and adenosine in enhancing NOS II gene expression in interleukin-1 beta-stimulated rat vascular smooth muscle cells. Adenosine 32-41 interleukin 1 beta Rattus norvegicus 81-99 9179586-1 1997 The production of nitric oxide (NO) by vascular smooth muscle cells (VSMC) is stimulated by interleukin-1 beta (IL-1 beta). Nitric Oxide 18-30 interleukin 1 beta Rattus norvegicus 92-110 9179586-1 1997 The production of nitric oxide (NO) by vascular smooth muscle cells (VSMC) is stimulated by interleukin-1 beta (IL-1 beta). Nitric Oxide 18-30 interleukin 1 beta Rattus norvegicus 112-121 9179586-5 1997 8-(p-Sulfophenyl)-theophylline, a blocker of adenosine receptors, suppressed the enhanced NO production by adenosine and ADP to the level of that with IL-1 beta alone. 8-(4-sulfophenyl)theophylline 0-30 interleukin 1 beta Rattus norvegicus 151-160 9179586-5 1997 8-(p-Sulfophenyl)-theophylline, a blocker of adenosine receptors, suppressed the enhanced NO production by adenosine and ADP to the level of that with IL-1 beta alone. Adenosine 45-54 interleukin 1 beta Rattus norvegicus 151-160 9179586-5 1997 8-(p-Sulfophenyl)-theophylline, a blocker of adenosine receptors, suppressed the enhanced NO production by adenosine and ADP to the level of that with IL-1 beta alone. Adenosine Diphosphate 121-124 interleukin 1 beta Rattus norvegicus 151-160 9139981-6 1997 After long-term treatment with IL-1beta or TNF, but not IL-1alpha, the significantly elevated levels of basal systolic calcium remain, and isoproterenol increases adenylate cyclase activity, unlike after short exposure. Calcium 119-126 interleukin 1 beta Rattus norvegicus 31-39 9225331-11 1997 In addition, interleukin-1 beta, an endogenous pyrogen, enhanced turnover of neuronal histamine through prostaglandin E2 in the brain. Histamine 86-95 interleukin 1 beta Rattus norvegicus 13-31 9225331-11 1997 In addition, interleukin-1 beta, an endogenous pyrogen, enhanced turnover of neuronal histamine through prostaglandin E2 in the brain. Dinoprostone 104-120 interleukin 1 beta Rattus norvegicus 13-31 9225134-3 1997 Spermine increased interleukin-1 beta (IL-1 beta), IL-6, and TNF-alpha plasma concentration. Spermine 0-8 interleukin 1 beta Rattus norvegicus 19-37 9225134-3 1997 Spermine increased interleukin-1 beta (IL-1 beta), IL-6, and TNF-alpha plasma concentration. Spermine 0-8 interleukin 1 beta Rattus norvegicus 39-48 9263201-0 1997 Interleukin-1 beta inhibits glutamate release in hippocampus of young, but not aged, rats. Glutamic Acid 28-37 interleukin 1 beta Rattus norvegicus 0-18 9263201-3 1997 We report that IL-1 beta has an inhibitory effect on KCl-stimulated release of glutamate and KC1-stimulated [45Ca] influx in synaptosomes prepared from hippocampus of 4-month-old rats. Potassium Chloride 53-56 interleukin 1 beta Rattus norvegicus 15-24 9263201-3 1997 We report that IL-1 beta has an inhibitory effect on KCl-stimulated release of glutamate and KC1-stimulated [45Ca] influx in synaptosomes prepared from hippocampus of 4-month-old rats. Glutamic Acid 79-88 interleukin 1 beta Rattus norvegicus 15-24 9263201-3 1997 We report that IL-1 beta has an inhibitory effect on KCl-stimulated release of glutamate and KC1-stimulated [45Ca] influx in synaptosomes prepared from hippocampus of 4-month-old rats. kc1 93-96 interleukin 1 beta Rattus norvegicus 15-24 9145941-4 1997 The IL-1beta-induced decrease in sodium excretion was abolished in renal-denervated rats. Sodium 33-39 interleukin 1 beta Rattus norvegicus 4-12 9108779-4 1997 Exposure of cultured SMCs to IL-1 beta increased NF-kappa B binding activity within 30 minutes and was associated with nitrite accumulation and the appearance of iNOS protein 24 hours later. Nitrites 119-126 interleukin 1 beta Rattus norvegicus 29-38 9108779-7 1997 Exposure of rat aortic segments without endothelium to IL-1 beta activated NF-kappa B within 30 minutes and was associated with the appearance of iNOS mRNA and an attenuation of phenylephrine-induced contraction 6 hours later. Phenylephrine 178-191 interleukin 1 beta Rattus norvegicus 55-64 9139981-6 1997 After long-term treatment with IL-1beta or TNF, but not IL-1alpha, the significantly elevated levels of basal systolic calcium remain, and isoproterenol increases adenylate cyclase activity, unlike after short exposure. Isoproterenol 139-152 interleukin 1 beta Rattus norvegicus 31-39 9126707-6 1997 Adenosine augmented adrenal IL-6 release stimulated by endotoxin (LPS), interleukin 1 beta (IL-1 beta), adrenocorticotrophic hormone, and angiotensin II. Adenosine 0-9 interleukin 1 beta Rattus norvegicus 72-90 9179872-4 1997 A tyrosine kinase antagonist genistein (50 microM) but not a protein kinase C inhibitor H7 (30 microM) prevented the inhibition of the ET response by IL-1 beta and LPS. Genistein 29-38 interleukin 1 beta Rattus norvegicus 150-159 9143738-5 1997 By 7 days postoperatively IL-1 beta had decreased the hydroxyproline content of granulation tissue. Hydroxyproline 54-68 interleukin 1 beta Rattus norvegicus 26-35 9143738-7 1997 In IL-1 beta-treated fibroblast cultures collagen production decreased by 15% and following PGE2 treatment by 34% compared with the controls. Dinoprostone 92-96 interleukin 1 beta Rattus norvegicus 3-12 9134219-7 1997 Staurosporine also synergistically potentiated the stimulating effect of interleukin-1 beta (IL-1 beta), but not that of the adenylyl cyclase activator, forskolin, on NO2- production and iNOS protein abundance. Staurosporine 0-13 interleukin 1 beta Rattus norvegicus 73-91 9134219-7 1997 Staurosporine also synergistically potentiated the stimulating effect of interleukin-1 beta (IL-1 beta), but not that of the adenylyl cyclase activator, forskolin, on NO2- production and iNOS protein abundance. Staurosporine 0-13 interleukin 1 beta Rattus norvegicus 93-102 9134219-9 1997 The effect of staurosporine on both basal and IL-1 beta-stimulated NO2- production was concentration-dependent with an apparent maximum at 3 nM. Staurosporine 14-27 interleukin 1 beta Rattus norvegicus 46-55 9134219-9 1997 The effect of staurosporine on both basal and IL-1 beta-stimulated NO2- production was concentration-dependent with an apparent maximum at 3 nM. Nitrogen Dioxide 67-70 interleukin 1 beta Rattus norvegicus 46-55 9134219-10 1997 Among the other protein kinase inhibitors tested, only calphostin C also enhanced the stimulant effect of IL-1 beta approximately two fold, while genistein, erbstatin A and Ro 31-8220 inhibited rather than potentiated it. calphostin C 55-67 interleukin 1 beta Rattus norvegicus 106-115 9134219-13 1997 Moreover, staurosporine significantly augmented the activation of C/EBP by IL-1 beta and forskolin. Staurosporine 10-23 interleukin 1 beta Rattus norvegicus 75-84 9048602-0 1997 Inhibition of gonadotropin-induced testosterone secretion by the intracerebroventricular injection of interleukin-1 beta in the male rat. Testosterone 35-47 interleukin 1 beta Rattus norvegicus 102-120 9048602-1 1997 The intracerebroventricular (icv) injection of the proinflammatory cytokine interleukin (IL)-1 beta is known to significantly decrease plasma LH levels in the male rat, thereby lowering testosterone (T) secretion. Luteinizing Hormone 142-144 interleukin 1 beta Rattus norvegicus 76-99 9048602-1 1997 The intracerebroventricular (icv) injection of the proinflammatory cytokine interleukin (IL)-1 beta is known to significantly decrease plasma LH levels in the male rat, thereby lowering testosterone (T) secretion. Testosterone 186-198 interleukin 1 beta Rattus norvegicus 76-99 9048602-4 1997 Elevations in plasma corticosterone levels do not seem to play a role either, because icv IL-1 beta is able to blunt hCG-induced T secretion in animals whose corticosterone has been removed by adrenalectomy or reduced by the administration of antibodies to CRF. Corticosterone 158-172 interleukin 1 beta Rattus norvegicus 90-99 9048612-0 1997 Inhibition by interleukin-1 beta and tumor necrosis factor-alpha of the insulin-like growth factor I messenger ribonucleic acid response to growth hormone in rat hepatocyte primary culture. Growth Hormone 140-154 interleukin 1 beta Rattus norvegicus 14-100 9195371-10 1997 The expression of TNF-alpha, IL-1 alpha, IL-1 beta and IL-6 mRNA were elevated between 1 and 6 h post-LPS in the livers of both control and ethanol-fed rats. Ethanol 140-147 interleukin 1 beta Rattus norvegicus 41-50 9101730-7 1997 Treatment of astrocytes with IL-1beta induced a dose-dependent inhibition of estradiol production. Estradiol 77-86 interleukin 1 beta Rattus norvegicus 29-37 9126707-6 1997 Adenosine augmented adrenal IL-6 release stimulated by endotoxin (LPS), interleukin 1 beta (IL-1 beta), adrenocorticotrophic hormone, and angiotensin II. Adenosine 0-9 interleukin 1 beta Rattus norvegicus 92-101 9126707-7 1997 LPS- and IL-1 beta-stimulated adrenal TNF release was inhibited by adenosine. Adenosine 67-76 interleukin 1 beta Rattus norvegicus 9-18 10072973-0 1997 Effects of dexamethasone and ibuprofen on LPS-induced gene expression of TNF alpha, IL-1 beta, and MIP-1 alpha in rat lung. Ibuprofen 29-38 interleukin 1 beta Rattus norvegicus 84-93 9135517-3 1997 AIMS: To investigate the profile of IL-1 beta mRNA in the colonic muscle of rats with acetic acid induced colitis. Acetic Acid 86-97 interleukin 1 beta Rattus norvegicus 36-45 9058772-3 1997 Thymulin injection also doubled IL-1beta level in the liver of these animals. Thymic Factor, Circulating 0-8 interleukin 1 beta Rattus norvegicus 32-40 9058772-4 1997 Induced hyperalgesia was reversed completely by alpha-MSH related tripeptide, Lys-D-Pro-Val in low doses, which is known to antagonize IL-1beta and PGE2 induced hyperalgesia, but was only partly reversed by IL-1beta related tripeptide, Lys-D-Pro-Thr at high doses, which is known to antagonize IL-1beta induced hyperalgesia only. tripeptide K-26 66-76 interleukin 1 beta Rattus norvegicus 135-143 9058772-4 1997 Induced hyperalgesia was reversed completely by alpha-MSH related tripeptide, Lys-D-Pro-Val in low doses, which is known to antagonize IL-1beta and PGE2 induced hyperalgesia, but was only partly reversed by IL-1beta related tripeptide, Lys-D-Pro-Thr at high doses, which is known to antagonize IL-1beta induced hyperalgesia only. tripeptide K-26 66-76 interleukin 1 beta Rattus norvegicus 207-215 9058772-4 1997 Induced hyperalgesia was reversed completely by alpha-MSH related tripeptide, Lys-D-Pro-Val in low doses, which is known to antagonize IL-1beta and PGE2 induced hyperalgesia, but was only partly reversed by IL-1beta related tripeptide, Lys-D-Pro-Thr at high doses, which is known to antagonize IL-1beta induced hyperalgesia only. tripeptide K-26 66-76 interleukin 1 beta Rattus norvegicus 207-215 9058772-4 1997 Induced hyperalgesia was reversed completely by alpha-MSH related tripeptide, Lys-D-Pro-Val in low doses, which is known to antagonize IL-1beta and PGE2 induced hyperalgesia, but was only partly reversed by IL-1beta related tripeptide, Lys-D-Pro-Thr at high doses, which is known to antagonize IL-1beta induced hyperalgesia only. lys-d-pro-val 78-91 interleukin 1 beta Rattus norvegicus 135-143 9058772-4 1997 Induced hyperalgesia was reversed completely by alpha-MSH related tripeptide, Lys-D-Pro-Val in low doses, which is known to antagonize IL-1beta and PGE2 induced hyperalgesia, but was only partly reversed by IL-1beta related tripeptide, Lys-D-Pro-Thr at high doses, which is known to antagonize IL-1beta induced hyperalgesia only. lys-d-pro-val 78-91 interleukin 1 beta Rattus norvegicus 207-215 9058772-4 1997 Induced hyperalgesia was reversed completely by alpha-MSH related tripeptide, Lys-D-Pro-Val in low doses, which is known to antagonize IL-1beta and PGE2 induced hyperalgesia, but was only partly reversed by IL-1beta related tripeptide, Lys-D-Pro-Thr at high doses, which is known to antagonize IL-1beta induced hyperalgesia only. lys-d-pro-val 78-91 interleukin 1 beta Rattus norvegicus 207-215 9058390-7 1997 Moreover, the effect of IL-1 beta was attenuated by L-NAME. NG-Nitroarginine Methyl Ester 52-58 interleukin 1 beta Rattus norvegicus 24-33 9063726-5 1997 Production of IL-1 beta and NO was determined by measurement of IL-1 beta and nitrite concentrations in cell lysates and the culture medium, respectively. Nitrites 78-85 interleukin 1 beta Rattus norvegicus 14-23 9130760-6 1997 The IL-1beta-stimulated NO production was inhibited by the NOS inhibitor, L-NMMA, whose effects were reversed by L-arginine. omega-N-Methylarginine 74-80 interleukin 1 beta Rattus norvegicus 4-12 9130760-6 1997 The IL-1beta-stimulated NO production was inhibited by the NOS inhibitor, L-NMMA, whose effects were reversed by L-arginine. Arginine 113-123 interleukin 1 beta Rattus norvegicus 4-12 10072973-10 1997 After Dex or Ibu pretreatment, the peak levels of TNF alpha, IL-1 beta, and MIP-1 alpha mRNA decreased markedly compared with LPS alone. Dexamethasone 6-9 interleukin 1 beta Rattus norvegicus 61-70 10072973-10 1997 After Dex or Ibu pretreatment, the peak levels of TNF alpha, IL-1 beta, and MIP-1 alpha mRNA decreased markedly compared with LPS alone. Ibuprofen 13-16 interleukin 1 beta Rattus norvegicus 61-70 9124287-3 1997 When measured in the absence of Ca2+ with plasmenylcholine, exposure to 5 ng/ml IL-1beta caused an increase in membrane-associated PLA2 activity for 10 min that returned to basal levels by 20 min. choline plasmalogens 42-58 interleukin 1 beta Rattus norvegicus 80-88 9058422-0 1997 Effects of area postrema lesion and abdominal vagotomy on interleukin-1 beta-induced norepinephrine release in the hypothalamic paraventricular nucleus region in the rat. Norepinephrine 85-99 interleukin 1 beta Rattus norvegicus 58-76 9058422-1 1997 Peripherally administered interleukin-1 beta (IL-1 beta) has been shown to increase extracellular norepinephrine (NE) concentration in the paraventricular nucleus (PVN) of the hypothalamus. Norepinephrine 98-112 interleukin 1 beta Rattus norvegicus 26-44 9058422-1 1997 Peripherally administered interleukin-1 beta (IL-1 beta) has been shown to increase extracellular norepinephrine (NE) concentration in the paraventricular nucleus (PVN) of the hypothalamus. Norepinephrine 98-112 interleukin 1 beta Rattus norvegicus 46-55 9038369-0 1997 Dexamethasone differently modulates TNF-alpha- and IL-1beta-induced transcription of the hepatic Mn-superoxide dismutase gene. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 51-59 9124343-5 1997 Like TNF-alpha, genistein inhibited induction of NOS protein by a second proinflammatory cytokine, interleukin-1beta, suggesting similar activation mechanisms by proinflammatory cytokines. Genistein 16-25 interleukin 1 beta Rattus norvegicus 99-116 9124287-4 1997 In the presence of Ca2+ with phosphatidylcholine, IL-1beta had no effect on membrane-associated PLA2 but decreased cytosolic PLA2 activity. Phosphatidylcholines 29-48 interleukin 1 beta Rattus norvegicus 50-58 9124287-5 1997 Additionally, IL-1beta caused an increase in arachidonic acid release in 20 min. Arachidonic Acid 45-61 interleukin 1 beta Rattus norvegicus 14-22 9124287-6 1997 Pretreatment with E-6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one, a selective Ca2+-independent PLA2 inhibitor, blocked IL-1beta-induced increases in both PLA2 activity and arachidonic acid release. e-6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-2h-pyran-2-one 18-82 interleukin 1 beta Rattus norvegicus 137-145 9124287-6 1997 Pretreatment with E-6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one, a selective Ca2+-independent PLA2 inhibitor, blocked IL-1beta-induced increases in both PLA2 activity and arachidonic acid release. Arachidonic Acid 190-206 interleukin 1 beta Rattus norvegicus 137-145 9049474-2 1997 Rat aorta and islet endothelial cells can be activated in vitro to express inducible nitric oxide synthase by a cytokine mixture of tumour necrosis factor-alpha, gamma-interferon, and interleukin-1 beta and to produce high concentrations of nitric oxide. Nitric Oxide 85-97 interleukin 1 beta Rattus norvegicus 162-202 9021956-0 1997 The anti-inflammatory drug sodium salicylate inhibits nitric oxide formation induced by interleukin-1beta at a translational step, but not at a transcriptional step, in hepatocytes. Sodium Salicylate 27-44 interleukin 1 beta Rattus norvegicus 88-105 9024290-8 1997 IL-1 beta (2 U/mL) stimulated basal histamine secretion and nitric oxide production within 60 minutes and cyclic guanosine monophosphate production within 20 minutes. Histamine 36-45 interleukin 1 beta Rattus norvegicus 0-9 9024290-8 1997 IL-1 beta (2 U/mL) stimulated basal histamine secretion and nitric oxide production within 60 minutes and cyclic guanosine monophosphate production within 20 minutes. Nitric Oxide 60-72 interleukin 1 beta Rattus norvegicus 0-9 9024290-8 1997 IL-1 beta (2 U/mL) stimulated basal histamine secretion and nitric oxide production within 60 minutes and cyclic guanosine monophosphate production within 20 minutes. Cyclic GMP 106-136 interleukin 1 beta Rattus norvegicus 0-9 9024290-9 1997 Pretreatment for 20 minutes with IL-1 beta (2 U/mL) attenuated gastrin-stimulated histamine secretion by 40%-50%, reversed by the IL-1 receptor antagonist (10 U/ mL). Histamine 82-91 interleukin 1 beta Rattus norvegicus 33-42 9024290-12 1997 Cells pretreated with IL-1 beta did not respond to gastrin after a further 48-hour culture and showed decreased histamine content. Histamine 112-121 interleukin 1 beta Rattus norvegicus 22-31 9021956-0 1997 The anti-inflammatory drug sodium salicylate inhibits nitric oxide formation induced by interleukin-1beta at a translational step, but not at a transcriptional step, in hepatocytes. Nitric Oxide 54-66 interleukin 1 beta Rattus norvegicus 88-105 9021956-3 1997 We have previously reported that, in cultured rat hepatocytes, a single cytokine interleukin-1beta (IL-1beta) stimulated a release of nitrite, an oxidation product of NO, into culture medium dose- and time-dependently. Nitrites 134-141 interleukin 1 beta Rattus norvegicus 81-98 9021956-3 1997 We have previously reported that, in cultured rat hepatocytes, a single cytokine interleukin-1beta (IL-1beta) stimulated a release of nitrite, an oxidation product of NO, into culture medium dose- and time-dependently. Nitrites 134-141 interleukin 1 beta Rattus norvegicus 100-108 9021956-7 1997 Sodium salicylate markedly inhibited the NO formation induced by IL-1beta, but did not affect NF-kappaB activation and iNOS mRNA induction. Sodium Salicylate 0-17 interleukin 1 beta Rattus norvegicus 65-73 9013984-10 1997 IL-1beta also induced NO production in these cells, which was inhibited by NG-monomethyl-L-arginine. omega-N-Methylarginine 75-99 interleukin 1 beta Rattus norvegicus 0-8 9013984-11 1997 Similarly, IL-1beta-induced apoptosis and inhibition of actin expression were inhibited by this arginine analogue. Arginine 96-104 interleukin 1 beta Rattus norvegicus 11-19 9016800-5 1997 These results suggest 12-HETE is a novel upstream signal for IL-1beta induced JNK activation in RIN m5F cells. 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 22-29 interleukin 1 beta Rattus norvegicus 61-69 9020502-0 1997 Cytokines (IL-1beta and TNFalpha) in relation to biochemical and immunological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rats. Polychlorinated Dibenzodioxins 90-125 interleukin 1 beta Rattus norvegicus 11-19 8994052-1 1997 The capacity of the proinflammatory cytokines, tumor necrosis factor alpha (TNF alpha) and interleukin 1 beta (IL-1 beta), to modulate the sensitivity of isolated sensory neurons grown in culture to the excitatory chemical agent capsaicin was examined. Capsaicin 229-238 interleukin 1 beta Rattus norvegicus 91-109 8994052-1 1997 The capacity of the proinflammatory cytokines, tumor necrosis factor alpha (TNF alpha) and interleukin 1 beta (IL-1 beta), to modulate the sensitivity of isolated sensory neurons grown in culture to the excitatory chemical agent capsaicin was examined. Capsaicin 229-238 interleukin 1 beta Rattus norvegicus 111-120 9550283-0 1997 Interleukin-13 counteracts suppression induced by interleukin-1beta of glucose metabolism but not of insulin secretion in rat pancreatic islets. Glucose 71-78 interleukin 1 beta Rattus norvegicus 50-67 9038808-3 1997 In L6 cells, the combination of interleukin-1 beta and interferon-gamma induced a marked accumulation of nitrite, a stable metabolite of nitric oxide. Nitrites 105-112 interleukin 1 beta Rattus norvegicus 32-50 9038808-3 1997 In L6 cells, the combination of interleukin-1 beta and interferon-gamma induced a marked accumulation of nitrite, a stable metabolite of nitric oxide. Nitric Oxide 137-149 interleukin 1 beta Rattus norvegicus 32-50 9020502-8 1997 These results suggest that at low doses of TCDD, increased IL-1beta could be responsible for immune function stimulation, whereas at high doses of TCDD, greatly elevated TNFalpha and IL-1beta levles may exacerbate or mediate acute toxicity including immune suppression and related biochemical effects. Polychlorinated Dibenzodioxins 43-47 interleukin 1 beta Rattus norvegicus 59-67 9020502-10 1997 This change was accompanied by a transient increase of mRNA levels of IL-1beta at day 4 after TCDD dosage. Polychlorinated Dibenzodioxins 94-98 interleukin 1 beta Rattus norvegicus 70-78 9020502-11 1997 Thus, these data demonstrated that TCDD alone (without immunization) can cause transient increases of mRNA levels of TNFalpha and IL-1beta in liver. Polychlorinated Dibenzodioxins 35-39 interleukin 1 beta Rattus norvegicus 130-138 8995451-8 1997 Finally, endogenous NO formation, induced in hepatocytes stimulated with interferon-gamma and interleukin-1beta, led to the formation of GSNO and GSSG, induced HSP70, and attenuated TNFalpha-mediated cytotoxicity. S-Nitrosoglutathione 137-141 interleukin 1 beta Rattus norvegicus 94-111 8995451-8 1997 Finally, endogenous NO formation, induced in hepatocytes stimulated with interferon-gamma and interleukin-1beta, led to the formation of GSNO and GSSG, induced HSP70, and attenuated TNFalpha-mediated cytotoxicity. Glutathione Disulfide 146-150 interleukin 1 beta Rattus norvegicus 94-111 9006348-0 1997 Interleukin-1 beta-induced disruption of the retinal vascular barrier of the central nervous system is mediated through leukocyte recruitment and histamine. Histamine 146-155 interleukin 1 beta Rattus norvegicus 0-18 9006348-6 1997 After IL-1 beta administration, a biphasic opening of the BRB to [14C]mannitol was recorded, peaking at 4 to 8 hours and 24 to 48 hours post-injection (PI). Carbon-14 66-69 interleukin 1 beta Rattus norvegicus 6-15 9006348-6 1997 After IL-1 beta administration, a biphasic opening of the BRB to [14C]mannitol was recorded, peaking at 4 to 8 hours and 24 to 48 hours post-injection (PI). Mannitol 70-78 interleukin 1 beta Rattus norvegicus 6-15 9006348-11 1997 The IL-1 beta-induced increase in permeability could be completely abrogated at 4 and 24 hours PI by treating the animals with the histamine H2-receptor antagonist ranitidine, which also reduced leukocyte infiltration by 47.2%. Ranitidine 164-174 interleukin 1 beta Rattus norvegicus 4-13 9006348-15 1997 These data demonstrate that intravitreal IL-1 beta in the rat induces a biphasic opening of the BRB that appears to be mediated through recruited leukocytes and release of the vasoactive amine histamine. Amines 187-192 interleukin 1 beta Rattus norvegicus 41-50 9006348-15 1997 These data demonstrate that intravitreal IL-1 beta in the rat induces a biphasic opening of the BRB that appears to be mediated through recruited leukocytes and release of the vasoactive amine histamine. Histamine 193-202 interleukin 1 beta Rattus norvegicus 41-50 9550283-2 1997 It has also been suggested that this action by IL-1beta is mediated by nitric oxide (NO) generation. Nitric Oxide 71-83 interleukin 1 beta Rattus norvegicus 47-55 9550283-8 1997 The highest concentration of IL-13 counteracted IL-1beta suppression of islet glucose oxidation, but not insulin release. Glucose 78-85 interleukin 1 beta Rattus norvegicus 48-56 9550283-12 1997 In conclusion, the present study showed that IL-13 could partially prevent IL-1beta induced inhibition of the glucose metabolism, and this effect appeared to be unrelated to NO levels. Glucose 110-117 interleukin 1 beta Rattus norvegicus 75-83 9042373-5 1997 In this study, we studied in the preoptic area (POA) the possible role of PGs and NO in the antidipsogenic action induced by IL-1 beta. Prostaglandins 74-77 interleukin 1 beta Rattus norvegicus 125-134 8977420-8 1997 Treatment with cycloheximide, a protein synthesis inhibitor, resulted in significant attenuation of the ability of IL-1 beta to up-regulate sPLA2 and cPLA2 gene expression as well as medium PLA2 activity. Cycloheximide 15-28 interleukin 1 beta Rattus norvegicus 115-124 8977420-9 1997 Treatment with aminoguanidine, an inhibitor of inducible nitric oxide synthase, led to augmentation of the ability of IL-1 beta to up-regulate sPLA2 and cPLA2 gene expression as well as medium PLA2 activity. pimagedine 15-29 interleukin 1 beta Rattus norvegicus 118-127 9093018-4 1997 Combined systemic administration of betamethasone dipropionate and betamethasone reduced the inhibitory effect of betamethasone on cell infiltration and gene expression of IL-1 beta. betamethasone-17,21-dipropionate 36-62 interleukin 1 beta Rattus norvegicus 172-181 9093018-4 1997 Combined systemic administration of betamethasone dipropionate and betamethasone reduced the inhibitory effect of betamethasone on cell infiltration and gene expression of IL-1 beta. Betamethasone 36-49 interleukin 1 beta Rattus norvegicus 172-181 9093018-4 1997 Combined systemic administration of betamethasone dipropionate and betamethasone reduced the inhibitory effect of betamethasone on cell infiltration and gene expression of IL-1 beta. Betamethasone 67-80 interleukin 1 beta Rattus norvegicus 172-181 9039082-3 1997 Incubation of the cultures with interleukin-1 beta (10 ng/mL) for 24 hours caused a significant increase in nitrite production. Nitrites 108-115 interleukin 1 beta Rattus norvegicus 32-50 9039082-4 1997 Endothelin-1 significantly decreased the interleukin-1 beta-induced nitrite production by vascular smooth muscle cells in a dose-dependent manner (10(-11) to 10(-8) mol/L). Nitrites 68-75 interleukin 1 beta Rattus norvegicus 41-59 9039082-8 1997 These results indicate that endothelin-1 acts on endothelin type A receptors and inhibits nitric oxide synthesis in interleukin-1 beta-stimulated vascular smooth muscle cells at least partially through a protein kinase C-dependent pathway. Nitric Oxide 90-102 interleukin 1 beta Rattus norvegicus 116-134 9503251-3 1997 The extracellular 5-HIAA levels were not changed in the NRD after peripheral application of rat recombinant IFN-gamma, but elevated by the cytokines IL-1 beta and TNF-alpha. Hydroxyindoleacetic Acid 18-24 interleukin 1 beta Rattus norvegicus 149-158 9128919-10 1997 Although capsaicin treatment altered visceral chemosensory function, corneal and pain sensitivity, vagal-mediated anorexic effects of cholecystokinin, and depleted levels of substance P in the thoracic spinal cord, it was completely ineffective in blocking the decrease in food-motivated behavior induced by IL-1beta (4 microg/rat I.P. Capsaicin 9-18 interleukin 1 beta Rattus norvegicus 308-316 9010260-3 1997 MC isolated from rat glomeruli generated substantial amounts of nitrite, the stable NO end-product, when cells were stimulated with IL-1beta and tumour necrosis factor-alpha (TNF-alpha). Nitrites 64-71 interleukin 1 beta Rattus norvegicus 132-140 9010260-4 1997 Total DNA synthesis was significantly reduced in the presence of IL-1beta and TNF-alpha, and this effect was completely reversed by N(G)-monomethyl-L-arginine (L-NMMA), an inhibitor of iNOS. omega-N-Methylarginine 132-158 interleukin 1 beta Rattus norvegicus 65-73 9010260-4 1997 Total DNA synthesis was significantly reduced in the presence of IL-1beta and TNF-alpha, and this effect was completely reversed by N(G)-monomethyl-L-arginine (L-NMMA), an inhibitor of iNOS. omega-N-Methylarginine 160-166 interleukin 1 beta Rattus norvegicus 65-73 9010260-5 1997 Stimulation of MC with IL-1beta and TNF-alpha caused remarkable toxicity to these cells, measured by the MTT test (3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide cleavage, specific cytotoxicity 41.5 +/- 20.3%), and much less prominent MC lysis (3H-thymidine release, specific cytolysis 11.5 +/- 5.3%). monooxyethylene trimethylolpropane tristearate 105-108 interleukin 1 beta Rattus norvegicus 23-31 9010260-5 1997 Stimulation of MC with IL-1beta and TNF-alpha caused remarkable toxicity to these cells, measured by the MTT test (3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide cleavage, specific cytotoxicity 41.5 +/- 20.3%), and much less prominent MC lysis (3H-thymidine release, specific cytolysis 11.5 +/- 5.3%). thiazolyl blue 115-175 interleukin 1 beta Rattus norvegicus 23-31 9010260-5 1997 Stimulation of MC with IL-1beta and TNF-alpha caused remarkable toxicity to these cells, measured by the MTT test (3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide cleavage, specific cytotoxicity 41.5 +/- 20.3%), and much less prominent MC lysis (3H-thymidine release, specific cytolysis 11.5 +/- 5.3%). Tritium 259-261 interleukin 1 beta Rattus norvegicus 23-31 9010260-5 1997 Stimulation of MC with IL-1beta and TNF-alpha caused remarkable toxicity to these cells, measured by the MTT test (3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide cleavage, specific cytotoxicity 41.5 +/- 20.3%), and much less prominent MC lysis (3H-thymidine release, specific cytolysis 11.5 +/- 5.3%). Thymidine 262-271 interleukin 1 beta Rattus norvegicus 23-31 8977419-1 1997 Interleukin (IL)-1 beta has been shown to stimulate ovarian prostaglandin biosynthesis. Prostaglandins 60-73 interleukin 1 beta Rattus norvegicus 0-23 8977419-3 1997 Treatment of cultured whole ovarian dispersates of immature rat origin with IL-1 beta produced significant increases in [3H]arachidonic acid (AA) release and [3H]prostanoid accumulation as well as increases in cellular PLA2 activity and in secretory PLA2 and cytosolic PLA2 transcripts. Tritium 121-123 interleukin 1 beta Rattus norvegicus 76-85 8977419-3 1997 Treatment of cultured whole ovarian dispersates of immature rat origin with IL-1 beta produced significant increases in [3H]arachidonic acid (AA) release and [3H]prostanoid accumulation as well as increases in cellular PLA2 activity and in secretory PLA2 and cytosolic PLA2 transcripts. Arachidonic Acid 124-140 interleukin 1 beta Rattus norvegicus 76-85 8977419-3 1997 Treatment of cultured whole ovarian dispersates of immature rat origin with IL-1 beta produced significant increases in [3H]arachidonic acid (AA) release and [3H]prostanoid accumulation as well as increases in cellular PLA2 activity and in secretory PLA2 and cytosolic PLA2 transcripts. Tritium 159-161 interleukin 1 beta Rattus norvegicus 76-85 8977419-3 1997 Treatment of cultured whole ovarian dispersates of immature rat origin with IL-1 beta produced significant increases in [3H]arachidonic acid (AA) release and [3H]prostanoid accumulation as well as increases in cellular PLA2 activity and in secretory PLA2 and cytosolic PLA2 transcripts. Prostaglandins 162-172 interleukin 1 beta Rattus norvegicus 76-85 8977419-5 1997 Treatment with IL-1 beta also promoted a significant decrease in the cellular content of [3H]phospholipids (apparently phosphatidylethanolamine but not phosphatidylcholine). [3h]phospholipids 89-106 interleukin 1 beta Rattus norvegicus 15-24 8977419-5 1997 Treatment with IL-1 beta also promoted a significant decrease in the cellular content of [3H]phospholipids (apparently phosphatidylethanolamine but not phosphatidylcholine). phosphatidylethanolamine 119-143 interleukin 1 beta Rattus norvegicus 15-24 8977419-5 1997 Treatment with IL-1 beta also promoted a significant decrease in the cellular content of [3H]phospholipids (apparently phosphatidylethanolamine but not phosphatidylcholine). Phosphatidylcholines 152-171 interleukin 1 beta Rattus norvegicus 15-24 9042373-12 1997 In the POA a treatment with acetylsalicylic acid (ASA) (33, 66, and 135 micrograms/rat), but not with L-NAME, antagonized the inhibition of drinking behaviour induced by the highest doses of IL-1 beta in the POA. Aspirin 28-48 interleukin 1 beta Rattus norvegicus 191-200 9042373-12 1997 In the POA a treatment with acetylsalicylic acid (ASA) (33, 66, and 135 micrograms/rat), but not with L-NAME, antagonized the inhibition of drinking behaviour induced by the highest doses of IL-1 beta in the POA. Aspirin 50-53 interleukin 1 beta Rattus norvegicus 191-200 9042373-14 1997 Our data suggest that the central inhibition of drinking behaviour of IL-1 beta is mediated through the formation of PGs, but not NO, in the POA. Prostaglandins 117-120 interleukin 1 beta Rattus norvegicus 70-79 8976527-0 1997 Role of corticosterone in the behavioral effects of central interleukin-1 beta. Corticosterone 8-22 interleukin 1 beta Rattus norvegicus 60-78 8976527-6 1997 To verify that corticosterone was responsible for inhibiting the effects of IL-1 beta, corticosterone pellets or placebos were implanted i.p. Corticosterone 15-29 interleukin 1 beta Rattus norvegicus 76-85 8976527-10 1997 Corticosterone replacement, however, reversed this effect in ADX rats, confirming that corticosterone modulates the behavioral effects of peripheral IL-1 beta. Corticosterone 0-14 interleukin 1 beta Rattus norvegicus 149-158 8976527-10 1997 Corticosterone replacement, however, reversed this effect in ADX rats, confirming that corticosterone modulates the behavioral effects of peripheral IL-1 beta. Corticosterone 87-101 interleukin 1 beta Rattus norvegicus 149-158 8976527-16 1997 These results are interpreted to indicate that corticosterone inhibits the behavioral effects of IL-1 beta in the periphery and, perhaps, in the CNS. Corticosterone 47-61 interleukin 1 beta Rattus norvegicus 97-106 8988487-1 1996 The effect of intraportal administrations of interleukin 1 beta (IL-1 beta) on the afferent activity of the hepatic branch of the vagus nerve was observed in urethane anesthetized rats. Urethane 158-166 interleukin 1 beta Rattus norvegicus 45-63 8954984-1 1996 A dose-dependent decrease in the nitric oxide production induced by IL-1beta was observed when cell cultures were pretreated with high glucose. Nitric Oxide 33-45 interleukin 1 beta Rattus norvegicus 68-76 8954984-1 1996 A dose-dependent decrease in the nitric oxide production induced by IL-1beta was observed when cell cultures were pretreated with high glucose. Glucose 135-142 interleukin 1 beta Rattus norvegicus 68-76 8954984-6 1996 These findings suggest that high glucose in combination with stimulation by IL-1beta decreases iNOS expression and nitric oxide production, and protein kinase C activation may be playing a role in the inhibition of nitric oxide production by high glucose. Nitric Oxide 115-127 interleukin 1 beta Rattus norvegicus 76-84 8978456-5 1996 The regulation of collagenase gene by 1,25-(OH)2D3 and interleukin (IL)-1 beta in cultured proliferative chondrocytes was studied by means of steady-state mRNA and half-life determination of mRNA using the transcriptional inhibitor actinomycin D, and nuclear run-on transcription analyses. Dactinomycin 232-245 interleukin 1 beta Rattus norvegicus 55-78 8982720-0 1996 Nitric oxide mediates central activation of sympathetic outflow induced by interleukin-1 beta in rats. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 75-93 8982720-1 1996 The excitatory mechanism of central sympathetic outflow induced by interleukin-1 beta was investigated in urethane-anesthetized rats. Urethane 106-114 interleukin 1 beta Rattus norvegicus 67-85 8986132-4 1996 In the present study, we tested whether ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), a glutathione peroxidase mimicking compound, could counteract the effects of IL-1 beta, H2O2 and alloxan in rat pancreatic islets and in the rat insulinoma cell line RINm5F (RIN cells). ebselen 40-47 interleukin 1 beta Rattus norvegicus 168-177 8986132-4 1996 In the present study, we tested whether ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), a glutathione peroxidase mimicking compound, could counteract the effects of IL-1 beta, H2O2 and alloxan in rat pancreatic islets and in the rat insulinoma cell line RINm5F (RIN cells). ebselen 49-88 interleukin 1 beta Rattus norvegicus 168-177 8982720-2 1996 Intracerebroventricular administration of interleukin-1 beta induced a gradually developing elevation of plasma noradrenaline levels in a dose-dependent manner (50, 100 and 200 ng/animal), while the levels of adrenaline were not affected. Norepinephrine 112-125 interleukin 1 beta Rattus norvegicus 42-60 8986132-6 1996 Ebselen (20 microM) prevented the increase in nitrite production by rat islets exposed to IL-1 beta for 6 hr and induced significant protection against the acute inhibitory effects of alloxan or H2O2 exposure, as judged by the preserved glucose oxidation rates. ebselen 0-7 interleukin 1 beta Rattus norvegicus 90-99 8988487-1 1996 The effect of intraportal administrations of interleukin 1 beta (IL-1 beta) on the afferent activity of the hepatic branch of the vagus nerve was observed in urethane anesthetized rats. Urethane 158-166 interleukin 1 beta Rattus norvegicus 65-74 8986132-6 1996 Ebselen (20 microM) prevented the increase in nitrite production by rat islets exposed to IL-1 beta for 6 hr and induced significant protection against the acute inhibitory effects of alloxan or H2O2 exposure, as judged by the preserved glucose oxidation rates. Nitrites 46-53 interleukin 1 beta Rattus norvegicus 90-99 8982720-11 1996 The present results suggest that nitric oxide is involved in the interleukin-1 beta-induced central activation of sympathetic outflow. Nitric Oxide 33-45 interleukin 1 beta Rattus norvegicus 65-83 8922366-0 1996 Dual functional effects of interleukin-1beta on purine nucleotides and insulin secretion in rat islets and INS-1 cells. purine 48-54 interleukin 1 beta Rattus norvegicus 27-44 8971291-12 1996 Water immersion stress increased gastric mucosal IL-1 beta and IL-2 contents 6 h after stress treatment, and these increases were prevented by FK506. Water 0-5 interleukin 1 beta Rattus norvegicus 49-58 8971291-12 1996 Water immersion stress increased gastric mucosal IL-1 beta and IL-2 contents 6 h after stress treatment, and these increases were prevented by FK506. Tacrolimus 143-148 interleukin 1 beta Rattus norvegicus 49-58 8955788-10 1996 Effects of dexamethasone were significantly ameliorated by IL-1 beta alone and combined with GM-CSF; those of PDTC were mitigated by M-CSF and a combination of IL-1 beta and TNF alpha but not by GM-CSF. Dexamethasone 11-24 interleukin 1 beta Rattus norvegicus 59-68 9050749-9 1996 Administration of high doses of DEX completely abolished the stimulation of the HPA axis by IL-1beta (2.0 microg/day). Dexamethasone 32-35 interleukin 1 beta Rattus norvegicus 92-100 9050749-15 1996 IL-1beta infusion, express an overall inhibitory rather than a stimulatory effect on the activity of the HPA axis; (4) demonstrates that exogenous administration of DEX blocks the effect of IL-1beta, which fits well in the concept of an immunoregulatory feedback between IL-1beta and glucocorticoids. Dexamethasone 165-168 interleukin 1 beta Rattus norvegicus 0-8 9050749-15 1996 IL-1beta infusion, express an overall inhibitory rather than a stimulatory effect on the activity of the HPA axis; (4) demonstrates that exogenous administration of DEX blocks the effect of IL-1beta, which fits well in the concept of an immunoregulatory feedback between IL-1beta and glucocorticoids. Dexamethasone 165-168 interleukin 1 beta Rattus norvegicus 190-198 9050749-15 1996 IL-1beta infusion, express an overall inhibitory rather than a stimulatory effect on the activity of the HPA axis; (4) demonstrates that exogenous administration of DEX blocks the effect of IL-1beta, which fits well in the concept of an immunoregulatory feedback between IL-1beta and glucocorticoids. Dexamethasone 165-168 interleukin 1 beta Rattus norvegicus 190-198 8997263-0 1996 IL-1 beta stimulates superoxide and delayed peroxynitrite production by pulmonary vascular smooth muscle cells. Superoxides 21-31 interleukin 1 beta Rattus norvegicus 0-9 8997263-0 1996 IL-1 beta stimulates superoxide and delayed peroxynitrite production by pulmonary vascular smooth muscle cells. Peroxynitrous Acid 44-57 interleukin 1 beta Rattus norvegicus 0-9 8997263-1 1996 Our previous studies have shown that rat pulmonary microvascular smooth muscle cells (RPMSMC) upregulate inducible nitric oxide synthase (iNOS) and produce nitric oxide (NO) when treated with interleukin-1 beta (IL-1 beta). Nitric Oxide 115-127 interleukin 1 beta Rattus norvegicus 192-210 8997263-1 1996 Our previous studies have shown that rat pulmonary microvascular smooth muscle cells (RPMSMC) upregulate inducible nitric oxide synthase (iNOS) and produce nitric oxide (NO) when treated with interleukin-1 beta (IL-1 beta). Nitric Oxide 115-127 interleukin 1 beta Rattus norvegicus 212-221 8997263-2 1996 We now report that an additional effect of IL-1 beta stimulation in RPMSMC is an increase in production of superoxide (O2-) that results in the formation of peroxynitrite (ONOO-). Superoxides 107-117 interleukin 1 beta Rattus norvegicus 43-52 8997263-2 1996 We now report that an additional effect of IL-1 beta stimulation in RPMSMC is an increase in production of superoxide (O2-) that results in the formation of peroxynitrite (ONOO-). Superoxides 119-121 interleukin 1 beta Rattus norvegicus 43-52 8997263-2 1996 We now report that an additional effect of IL-1 beta stimulation in RPMSMC is an increase in production of superoxide (O2-) that results in the formation of peroxynitrite (ONOO-). Peroxynitrous Acid 157-170 interleukin 1 beta Rattus norvegicus 43-52 8997263-2 1996 We now report that an additional effect of IL-1 beta stimulation in RPMSMC is an increase in production of superoxide (O2-) that results in the formation of peroxynitrite (ONOO-). oxido nitrite 172-177 interleukin 1 beta Rattus norvegicus 43-52 8997263-3 1996 IL-1 beta produced a rapid (within 1 h) concentration-dependent increase in O2-, as detected by ferricytochrome c reduction and lucigenin-enhanced chemiluminescence. Superoxides 76-78 interleukin 1 beta Rattus norvegicus 0-9 8997263-3 1996 IL-1 beta produced a rapid (within 1 h) concentration-dependent increase in O2-, as detected by ferricytochrome c reduction and lucigenin-enhanced chemiluminescence. 10,10'-dimethyl-9,9'-biacridinium 128-137 interleukin 1 beta Rattus norvegicus 0-9 8997263-7 1996 IL-1 beta-mediated induction of RPMSMC-derived ONOO- may have significant effects on pulmonary vascular function in sepsis and inflammatory states. rpmsmc 32-38 interleukin 1 beta Rattus norvegicus 0-9 8997263-7 1996 IL-1 beta-mediated induction of RPMSMC-derived ONOO- may have significant effects on pulmonary vascular function in sepsis and inflammatory states. onoo 47-51 interleukin 1 beta Rattus norvegicus 0-9 8922366-1 1996 Interleukin-1beta (IL-1beta) has been shown to inhibit glucose-induced insulin secretion from rat islets and purified beta-cells, primarily through the generation of nitric oxide (NO). Glucose 55-62 interleukin 1 beta Rattus norvegicus 0-17 8922366-1 1996 Interleukin-1beta (IL-1beta) has been shown to inhibit glucose-induced insulin secretion from rat islets and purified beta-cells, primarily through the generation of nitric oxide (NO). Glucose 55-62 interleukin 1 beta Rattus norvegicus 19-27 8922366-1 1996 Interleukin-1beta (IL-1beta) has been shown to inhibit glucose-induced insulin secretion from rat islets and purified beta-cells, primarily through the generation of nitric oxide (NO). Nitric Oxide 166-178 interleukin 1 beta Rattus norvegicus 0-17 21153080-8 1996 Serotonin potentiated IL-6 release stimulated by endotoxin and IL-1beta, but inhibited TNF release stimulated by these agents. Serotonin 0-9 interleukin 1 beta Rattus norvegicus 63-71 8922366-1 1996 Interleukin-1beta (IL-1beta) has been shown to inhibit glucose-induced insulin secretion from rat islets and purified beta-cells, primarily through the generation of nitric oxide (NO). Nitric Oxide 166-178 interleukin 1 beta Rattus norvegicus 19-27 8922366-5 1996 IL-1beta also diminished insulin secretion induced by pure mitochondrial fuels, 40 mmol/l K+, or a phorbol ester. Phorbol Esters 99-112 interleukin 1 beta Rattus norvegicus 0-8 8922366-6 1996 Concomitantly, IL-1beta significantly decreased islet ATP (-45%), GTP (-33%), ATP/ADP (-54%), and GTP/GDP (-46%). Adenosine Triphosphate 54-57 interleukin 1 beta Rattus norvegicus 15-23 8922366-6 1996 Concomitantly, IL-1beta significantly decreased islet ATP (-45%), GTP (-33%), ATP/ADP (-54%), and GTP/GDP (-46%). Guanosine Triphosphate 66-69 interleukin 1 beta Rattus norvegicus 15-23 8922366-6 1996 Concomitantly, IL-1beta significantly decreased islet ATP (-45%), GTP (-33%), ATP/ADP (-54%), and GTP/GDP (-46%). Adenosine Triphosphate 78-81 interleukin 1 beta Rattus norvegicus 15-23 8922366-6 1996 Concomitantly, IL-1beta significantly decreased islet ATP (-45%), GTP (-33%), ATP/ADP (-54%), and GTP/GDP (-46%). Adenosine Diphosphate 82-85 interleukin 1 beta Rattus norvegicus 15-23 8922366-6 1996 Concomitantly, IL-1beta significantly decreased islet ATP (-45%), GTP (-33%), ATP/ADP (-54%), and GTP/GDP (-46%). Guanosine Triphosphate 98-101 interleukin 1 beta Rattus norvegicus 15-23 8922366-6 1996 Concomitantly, IL-1beta significantly decreased islet ATP (-45%), GTP (-33%), ATP/ADP (-54%), and GTP/GDP (-46%). Guanosine Diphosphate 102-105 interleukin 1 beta Rattus norvegicus 15-23 8922366-10 1996 Concomitantly, in INS-1 cells, IL-1beta had no effect on ATP/ADP or GTP/GDP ratios, although it modestly decreased ATP (-25%) and GTP (-22%). Adenosine Triphosphate 115-118 interleukin 1 beta Rattus norvegicus 31-39 8922366-10 1996 Concomitantly, in INS-1 cells, IL-1beta had no effect on ATP/ADP or GTP/GDP ratios, although it modestly decreased ATP (-25%) and GTP (-22%). Guanosine Triphosphate 130-133 interleukin 1 beta Rattus norvegicus 31-39 8922366-12 1996 Thus, in rat islets, IL-1beta (via the generation of NO) abolishes insulin exocytosis in association with large decreases in the ATP/ADP (and GTP/GDP) ratio, implying the impairment of mitochondrial function. Adenosine Triphosphate 129-132 interleukin 1 beta Rattus norvegicus 21-29 8922366-12 1996 Thus, in rat islets, IL-1beta (via the generation of NO) abolishes insulin exocytosis in association with large decreases in the ATP/ADP (and GTP/GDP) ratio, implying the impairment of mitochondrial function. Adenosine Diphosphate 133-136 interleukin 1 beta Rattus norvegicus 21-29 8922366-12 1996 Thus, in rat islets, IL-1beta (via the generation of NO) abolishes insulin exocytosis in association with large decreases in the ATP/ADP (and GTP/GDP) ratio, implying the impairment of mitochondrial function. Guanosine Triphosphate 142-145 interleukin 1 beta Rattus norvegicus 21-29 8922366-12 1996 Thus, in rat islets, IL-1beta (via the generation of NO) abolishes insulin exocytosis in association with large decreases in the ATP/ADP (and GTP/GDP) ratio, implying the impairment of mitochondrial function. Guanosine Diphosphate 146-149 interleukin 1 beta Rattus norvegicus 21-29 8922366-13 1996 Furthermore, IL-1beta inhibits cytosolic synthesis of new purine nucleotides (via the salvage pathway), as assessed by a decrease in their specific activity after labeling with [3H]hypoxanthine. Purine Nucleotides 58-76 interleukin 1 beta Rattus norvegicus 13-21 8922366-13 1996 Furthermore, IL-1beta inhibits cytosolic synthesis of new purine nucleotides (via the salvage pathway), as assessed by a decrease in their specific activity after labeling with [3H]hypoxanthine. Tritium 178-180 interleukin 1 beta Rattus norvegicus 13-21 8922366-13 1996 Furthermore, IL-1beta inhibits cytosolic synthesis of new purine nucleotides (via the salvage pathway), as assessed by a decrease in their specific activity after labeling with [3H]hypoxanthine. Hypoxanthine 181-193 interleukin 1 beta Rattus norvegicus 13-21 8922366-14 1996 In contrast, in INS-1 cells, IL-1beta appears to impair cytosolic synthesis of purine nucleotides and insulin biosynthesis selectively (both possibly reflecting decreased glycolysis) with little direct effect on insulin exocytosis itself. Purine Nucleotides 79-97 interleukin 1 beta Rattus norvegicus 29-37 8938739-1 1996 In seven-day-old rats, intracerebral injection of N-methyl-D-aspartate transiently stimulates expression of Interleukin-1 beta messenger RNA. N-Methylaspartate 50-70 interleukin 1 beta Rattus norvegicus 108-126 9030978-3 1996 Inflammatory cytokines induced BH4 and NO synthesis in different ratios, IL-1 beta induced mainly NO synthesis with concomitant but limiting amounts of BH4 for maximal NO production. sapropterin 152-155 interleukin 1 beta Rattus norvegicus 73-82 8941724-0 1996 Aspirin inhibits expression of the interleukin-1beta-inducible group II phospholipase A2. Aspirin 0-7 interleukin 1 beta Rattus norvegicus 35-52 8947481-1 1996 The influence of the inflammatory mediators interleukin 1 beta (IL1 beta) and tumour necrosis factor alpha (TNF alpha) on the glucagon-induced expression of phosphoenolpyruvate carboxykinase (PCK) and on glucose formation via gluconeogenesis was investigated in cultured rat hepatocytes. Glucagon 126-134 interleukin 1 beta Rattus norvegicus 44-62 8947481-1 1996 The influence of the inflammatory mediators interleukin 1 beta (IL1 beta) and tumour necrosis factor alpha (TNF alpha) on the glucagon-induced expression of phosphoenolpyruvate carboxykinase (PCK) and on glucose formation via gluconeogenesis was investigated in cultured rat hepatocytes. Glucagon 126-134 interleukin 1 beta Rattus norvegicus 64-72 8953469-18 1996 Prostaglandins consistently mediate a stimulatory action of interleukin-1 beta on vasopressin release whereas alpha-adrenergic mechanisms mediate a depression of interleukin-1 beta-induced vasopressin release during the early to middle stages of lactation. Prostaglandins 0-14 interleukin 1 beta Rattus norvegicus 60-78 8941724-4 1996 Group II phospholipase A2 (sPLA2) is expressed in rat glomerular mesangial cells upon exposure to the inflammatory cytokine interleukin-1beta (IL-1beta) and this induction is attenuated by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 213-240 interleukin 1 beta Rattus norvegicus 124-141 8941724-4 1996 Group II phospholipase A2 (sPLA2) is expressed in rat glomerular mesangial cells upon exposure to the inflammatory cytokine interleukin-1beta (IL-1beta) and this induction is attenuated by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 213-240 interleukin 1 beta Rattus norvegicus 143-151 8941724-4 1996 Group II phospholipase A2 (sPLA2) is expressed in rat glomerular mesangial cells upon exposure to the inflammatory cytokine interleukin-1beta (IL-1beta) and this induction is attenuated by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 242-246 interleukin 1 beta Rattus norvegicus 124-141 8941724-4 1996 Group II phospholipase A2 (sPLA2) is expressed in rat glomerular mesangial cells upon exposure to the inflammatory cytokine interleukin-1beta (IL-1beta) and this induction is attenuated by the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC). pyrrolidine dithiocarbamic acid 242-246 interleukin 1 beta Rattus norvegicus 143-151 8941724-5 1996 We now report that aspirin inhibits the IL-1beta-induced sPLA2 activity in rat mesangial cells in a dose-dependent manner. Aspirin 19-26 interleukin 1 beta Rattus norvegicus 40-48 8981400-2 1996 Having hypothesized that perivascular nitric oxide (NO) might modulate the effects of systemic IL-1 beta in the brain, we studied the expression of the genes encoding for IL-1 beta, the signal-transducing IL-1 receptor type I (IL-1RI) and inducible NO synthase (iNOS) constitutively and during systemic inflammation in vascular and perivascular regions of the rat brain. Nitric Oxide 38-50 interleukin 1 beta Rattus norvegicus 95-104 8941724-7 1996 This decrease in sPLA2 activity was not due to direct inhibition of enzymatic activity but rather to the fact that aspirin inhibits the expression of IL-1beta-induced sPLA2 protein and mRNA. Aspirin 115-122 interleukin 1 beta Rattus norvegicus 150-158 8981400-2 1996 Having hypothesized that perivascular nitric oxide (NO) might modulate the effects of systemic IL-1 beta in the brain, we studied the expression of the genes encoding for IL-1 beta, the signal-transducing IL-1 receptor type I (IL-1RI) and inducible NO synthase (iNOS) constitutively and during systemic inflammation in vascular and perivascular regions of the rat brain. Nitric Oxide 38-50 interleukin 1 beta Rattus norvegicus 171-180 8941724-8 1996 Furthermore, by electrophoretic mobility shift analysis we demonstrate reduced DNA binding of the nuclear factor kappaB, an essential component of the IL-1beta-dependent upregulation of sPLA2 gene transcription, after treatment of the cells with aspirin. Aspirin 246-253 interleukin 1 beta Rattus norvegicus 151-159 8863535-2 1996 Although indirect evidence suggests that interleukin-1 beta is a mediator of NMDA neurotoxicity in perinatal rats, direct confirmation of NMDA-induced interleukin-1 beta production in the brain has not been reported previously. N-Methylaspartate 138-142 interleukin 1 beta Rattus norvegicus 151-169 8981429-5 1996 The combination of two techniques, reverse haemolytic plaque assay (RHPA) and terminal transferase dUTP nick end labelling (TUNEL), allowed us to observe simultaneously the release of IL-1 beta and apoptosis. deoxyuridine triphosphate 99-103 interleukin 1 beta Rattus norvegicus 184-193 8903404-7 1996 In the absence of the HSR, combinations of interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) stimulated high levels of NOS2 mRNA and nitric oxide (NO) synthesis. Nitric Oxide 187-199 interleukin 1 beta Rattus norvegicus 43-60 8903404-7 1996 In the absence of the HSR, combinations of interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) stimulated high levels of NOS2 mRNA and nitric oxide (NO) synthesis. Nitric Oxide 187-199 interleukin 1 beta Rattus norvegicus 62-70 8863535-0 1996 Intracerebral NMDA injection stimulates production of interleukin-1 beta in perinatal rat brain. N-Methylaspartate 14-18 interleukin 1 beta Rattus norvegicus 54-72 8945964-4 1996 The IL-1 beta-induced rise in colonic temperature was enhanced after the plateau phase of fever (from 240 min after IL-1 beta) in econazole-pretreated rats (P < 0.001). Econazole 130-139 interleukin 1 beta Rattus norvegicus 4-13 8945964-4 1996 The IL-1 beta-induced rise in colonic temperature was enhanced after the plateau phase of fever (from 240 min after IL-1 beta) in econazole-pretreated rats (P < 0.001). Econazole 130-139 interleukin 1 beta Rattus norvegicus 116-125 8945964-5 1996 Another cytochrome P-450 inhibitor, clotrimazole (15 mg/kg im), also enhanced IL-1 beta-induced fever from 160 min after IL-1 beta injection (P < 0.001). Clotrimazole 36-48 interleukin 1 beta Rattus norvegicus 78-87 8945964-5 1996 Another cytochrome P-450 inhibitor, clotrimazole (15 mg/kg im), also enhanced IL-1 beta-induced fever from 160 min after IL-1 beta injection (P < 0.001). Clotrimazole 36-48 interleukin 1 beta Rattus norvegicus 121-130 8945964-6 1996 Econazole also enhanced the fever when it was given 120 min before injection of IL-1 beta (P < 0.001). Econazole 0-9 interleukin 1 beta Rattus norvegicus 80-89 8895350-2 1996 NIC delays the formation of nitrite by interleukin (IL)-1 beta-(IL-1, 25 U/ml)-stimulated RINm5F cells, and previous exposure of cells to IL-1 for 15 h prevents this effect. Niacinamide 0-3 interleukin 1 beta Rattus norvegicus 39-68 8895350-2 1996 NIC delays the formation of nitrite by interleukin (IL)-1 beta-(IL-1, 25 U/ml)-stimulated RINm5F cells, and previous exposure of cells to IL-1 for 15 h prevents this effect. Nitrites 28-35 interleukin 1 beta Rattus norvegicus 39-68 8895359-0 1996 Lisofylline, an inhibitor of unsaturated phosphatidic acid generation, ameliorates interleukin-1 beta-induced dysfunction in cultured rat islets. lisofylline 0-11 interleukin 1 beta Rattus norvegicus 83-101 8895359-0 1996 Lisofylline, an inhibitor of unsaturated phosphatidic acid generation, ameliorates interleukin-1 beta-induced dysfunction in cultured rat islets. unsaturated phosphatidic acid 29-58 interleukin 1 beta Rattus norvegicus 83-101 8895359-2 1996 However, IL-1 beta also activates several lipid pathways, including those generating phosphatidic acid (PA). Phosphatidic Acids 85-102 interleukin 1 beta Rattus norvegicus 9-18 8895359-2 1996 However, IL-1 beta also activates several lipid pathways, including those generating phosphatidic acid (PA). Phosphatidic Acids 104-106 interleukin 1 beta Rattus norvegicus 9-18 8895359-3 1996 Lisofylline (LSF), a water-soluble, nontoxic, selective inhibitor of the PA-1 alpha subspecies, which is stimulated by IL-1 beta and tumor necrosis factor-alpha, has been shown to prevent cytokine-induced cytotoxicity in in vivo animal models. lisofylline 0-11 interleukin 1 beta Rattus norvegicus 119-160 8895359-3 1996 Lisofylline (LSF), a water-soluble, nontoxic, selective inhibitor of the PA-1 alpha subspecies, which is stimulated by IL-1 beta and tumor necrosis factor-alpha, has been shown to prevent cytokine-induced cytotoxicity in in vivo animal models. lisofylline 13-16 interleukin 1 beta Rattus norvegicus 119-160 8863535-2 1996 Although indirect evidence suggests that interleukin-1 beta is a mediator of NMDA neurotoxicity in perinatal rats, direct confirmation of NMDA-induced interleukin-1 beta production in the brain has not been reported previously. N-Methylaspartate 77-81 interleukin 1 beta Rattus norvegicus 41-59 8863535-3 1996 The primary goal of this study was to determine if intracerebral injection of a neurotoxic dose of NMDA stimulates interleukin-1 beta production acutely. N-Methylaspartate 99-103 interleukin 1 beta Rattus norvegicus 115-133 8863535-6 1996 Interleukin-1 beta concentrations were measured in samples from the injected and contralateral cerebral hemispheres 0-12 h later; In addition, the impact of treatment with the noncompetitive NMDA antagonist MK-801 on interleukin-1 beta production was assessed. Dizocilpine Maleate 207-213 interleukin 1 beta Rattus norvegicus 217-235 8863535-8 1996 Treatment with MK-801 (1 mg/kg) blocked NMDA-induced increases in interleukin-1 beta. Dizocilpine Maleate 15-21 interleukin 1 beta Rattus norvegicus 66-84 8863535-8 1996 Treatment with MK-801 (1 mg/kg) blocked NMDA-induced increases in interleukin-1 beta. N-Methylaspartate 40-44 interleukin 1 beta Rattus norvegicus 66-84 8863535-9 1996 Preliminary immunocytochemical analysis demonstrated high concentrations of interleukin-1 beta-immunoreactive cells in the lesioned hippocampus, and concurrent increases in interleukin-1 beta immunoreactivity diffusely in the ependyma at 6 h after NMDA administration. N-Methylaspartate 248-252 interleukin 1 beta Rattus norvegicus 173-191 8863535-10 1996 Our data provide the first direct evidence that NMDA-induced excitotoxic injury stimulates interleukin-1 beta production in vivo. N-Methylaspartate 48-52 interleukin 1 beta Rattus norvegicus 91-109 8948093-0 1996 Interleukin 1 beta and interleukin 6 repress clofibric acid induction of different P450 isoforms in cultured foetal rat hepatocytes. Clofibric Acid 45-59 interleukin 1 beta Rattus norvegicus 0-18 9266547-0 1996 Interleukin-1 beta-induced effects on plasma oxytocin and arginine vasopressin: role of adrenal steroids and route of administration. Steroids 96-104 interleukin 1 beta Rattus norvegicus 0-18 8948093-9 1996 The major pro-inflammatory cytokines, IL-1 beta and IL-6, decrease the levels of the clofibric acid-induced P450 isoforms, except CYP1A, which was insensitive to IL-6, previous studies having shown that IL-1 beta represses lauric acid 12-hydroxylase activity after induction by clofibric acid. Clofibric Acid 85-99 interleukin 1 beta Rattus norvegicus 38-47 8948093-9 1996 The major pro-inflammatory cytokines, IL-1 beta and IL-6, decrease the levels of the clofibric acid-induced P450 isoforms, except CYP1A, which was insensitive to IL-6, previous studies having shown that IL-1 beta represses lauric acid 12-hydroxylase activity after induction by clofibric acid. Clofibric Acid 85-99 interleukin 1 beta Rattus norvegicus 203-212 8948093-9 1996 The major pro-inflammatory cytokines, IL-1 beta and IL-6, decrease the levels of the clofibric acid-induced P450 isoforms, except CYP1A, which was insensitive to IL-6, previous studies having shown that IL-1 beta represses lauric acid 12-hydroxylase activity after induction by clofibric acid. Clofibric Acid 278-292 interleukin 1 beta Rattus norvegicus 38-47 8948093-9 1996 The major pro-inflammatory cytokines, IL-1 beta and IL-6, decrease the levels of the clofibric acid-induced P450 isoforms, except CYP1A, which was insensitive to IL-6, previous studies having shown that IL-1 beta represses lauric acid 12-hydroxylase activity after induction by clofibric acid. Clofibric Acid 278-292 interleukin 1 beta Rattus norvegicus 203-212 8911924-0 1996 Ethanol potentiates lipopolysaccharide- or interleukin-1 beta-induced nitric oxide generation in RBE4 cells. Ethanol 0-7 interleukin 1 beta Rattus norvegicus 43-61 8957237-2 1996 Incubation of the cultures with interleukin-1 beta (10 ng/ml) for 24 h caused a significant increase in the accumulation of nitrite, a stable metabolite of NO. Nitrites 124-131 interleukin 1 beta Rattus norvegicus 32-50 8957237-3 1996 Although cilostazol itself showed no effect on nitrite accumulation, it stimulated interleukin-1 beta-induced nitrite accumulation in a concentration-dependent manner (10(-8)-10(-5) M). Cilostazol 9-19 interleukin 1 beta Rattus norvegicus 83-101 8957237-3 1996 Although cilostazol itself showed no effect on nitrite accumulation, it stimulated interleukin-1 beta-induced nitrite accumulation in a concentration-dependent manner (10(-8)-10(-5) M). Nitrites 110-117 interleukin 1 beta Rattus norvegicus 83-101 8957237-6 1996 In the presence of dibutyryl-cAMP, interleukin-1 beta-induced nitrite accumulation was further increased, but the stimulatory effect of cilostazol on nitrite accumulation was blunted. Bucladesine 19-33 interleukin 1 beta Rattus norvegicus 35-53 8957237-6 1996 In the presence of dibutyryl-cAMP, interleukin-1 beta-induced nitrite accumulation was further increased, but the stimulatory effect of cilostazol on nitrite accumulation was blunted. Nitrites 62-69 interleukin 1 beta Rattus norvegicus 35-53 8957237-9 1996 These results indicate that cilostazol increases NO synthesis in interleukin-1 beta-stimulated smooth muscle cells, at least partially through a cAMP-dependent pathway. Cilostazol 28-38 interleukin 1 beta Rattus norvegicus 65-83 8957237-9 1996 These results indicate that cilostazol increases NO synthesis in interleukin-1 beta-stimulated smooth muscle cells, at least partially through a cAMP-dependent pathway. Cyclic AMP 145-149 interleukin 1 beta Rattus norvegicus 65-83 8911924-0 1996 Ethanol potentiates lipopolysaccharide- or interleukin-1 beta-induced nitric oxide generation in RBE4 cells. Nitric Oxide 70-82 interleukin 1 beta Rattus norvegicus 43-61 8911924-1 1996 Our present study investigated the effects of ethanol treatment on inducible nitric oxide (NO) synthase pathway from lipopolysaccharide- or interleukin-1 beta-treated cultured rat blood-brain barrier cell line (rat brain endothelial 4 cells: RBE4 cells). Ethanol 46-53 interleukin 1 beta Rattus norvegicus 140-158 8911924-1 1996 Our present study investigated the effects of ethanol treatment on inducible nitric oxide (NO) synthase pathway from lipopolysaccharide- or interleukin-1 beta-treated cultured rat blood-brain barrier cell line (rat brain endothelial 4 cells: RBE4 cells). Nitric Oxide 77-89 interleukin 1 beta Rattus norvegicus 140-158 8911924-4 1996 Lipopolysaccharide or interleukin-1 beta increased nitrite production and inducible NO synthase mRNA levels, and ethanol potentiated this effect. Nitrites 51-58 interleukin 1 beta Rattus norvegicus 22-40 8913777-5 1996 The antiinflammatory glucocorticoid dexamethasone also inhibits LIF mRNA induction by IL-1 beta. Dexamethasone 36-49 interleukin 1 beta Rattus norvegicus 86-95 8897830-7 1996 The addition of the glycolytic end product, pyruvate, completely blocked the 2-DG inhibition of IL-1 beta-stimulated NO2- production [7.4 +/- 0.4 nmol. Pyruvic Acid 44-52 interleukin 1 beta Rattus norvegicus 96-105 8897830-7 1996 The addition of the glycolytic end product, pyruvate, completely blocked the 2-DG inhibition of IL-1 beta-stimulated NO2- production [7.4 +/- 0.4 nmol. Deoxyglucose 77-81 interleukin 1 beta Rattus norvegicus 96-105 8897830-7 1996 The addition of the glycolytic end product, pyruvate, completely blocked the 2-DG inhibition of IL-1 beta-stimulated NO2- production [7.4 +/- 0.4 nmol. Nitrogen Dioxide 117-120 interleukin 1 beta Rattus norvegicus 96-105 8897830-13 1996 We report for the first time that optimal IL-1 beta-stimulated NO production by CM requires both glucose and the glycolytic end product pyruvate. Glucose 97-104 interleukin 1 beta Rattus norvegicus 42-51 8897830-13 1996 We report for the first time that optimal IL-1 beta-stimulated NO production by CM requires both glucose and the glycolytic end product pyruvate. Pyruvic Acid 136-144 interleukin 1 beta Rattus norvegicus 42-51 21153103-2 1996 We have previously shown that the NOS inhibitor, N(omega)-nitro-L-arginine methyl ester hydrochloride (L-NAME), markedly potentiates and prolongs the increase in plasma adrenocorticotropin (ACTH) concentrations produced by the intravenous injection of interleukin-1beta (IL-1beta) in the rat. n(omega)-nitro-l-arginine methyl ester hydrochloride 49-101 interleukin 1 beta Rattus norvegicus 252-269 21153103-2 1996 We have previously shown that the NOS inhibitor, N(omega)-nitro-L-arginine methyl ester hydrochloride (L-NAME), markedly potentiates and prolongs the increase in plasma adrenocorticotropin (ACTH) concentrations produced by the intravenous injection of interleukin-1beta (IL-1beta) in the rat. n(omega)-nitro-l-arginine methyl ester hydrochloride 49-101 interleukin 1 beta Rattus norvegicus 271-279 21153103-2 1996 We have previously shown that the NOS inhibitor, N(omega)-nitro-L-arginine methyl ester hydrochloride (L-NAME), markedly potentiates and prolongs the increase in plasma adrenocorticotropin (ACTH) concentrations produced by the intravenous injection of interleukin-1beta (IL-1beta) in the rat. NG-Nitroarginine Methyl Ester 103-109 interleukin 1 beta Rattus norvegicus 252-269 21153103-2 1996 We have previously shown that the NOS inhibitor, N(omega)-nitro-L-arginine methyl ester hydrochloride (L-NAME), markedly potentiates and prolongs the increase in plasma adrenocorticotropin (ACTH) concentrations produced by the intravenous injection of interleukin-1beta (IL-1beta) in the rat. NG-Nitroarginine Methyl Ester 103-109 interleukin 1 beta Rattus norvegicus 271-279 21153103-5 1996 Subcutaneous (sc) pretreatment with L-NAME (50-300 mumol/kg) produced the expected pronounced exacerbation of the ACTH response to IL-1beta. NG-Nitroarginine Methyl Ester 36-42 interleukin 1 beta Rattus norvegicus 131-139 8878428-3 1996 Contractile responses to electrical field stimulation and to carbachol were not altered, but maximal relaxation induced by isoproterenol (10(-6)-10(-5) M) was significantly reduced 24 h after IL-1beta treatment in tracheal tissues and to a lesser extent, in the main bronchi. Isoproterenol 123-136 interleukin 1 beta Rattus norvegicus 192-200 8878428-4 1996 Radioligand binding using [125I]iodocyanopindolol revealed a 32+/-7% reduction in beta-ARs in lung tissues from IL-1beta-treated rats, without any significant changes in beta2-AR mRNA level measured by Northern blot analysis. Iodocyanopindolol 32-49 interleukin 1 beta Rattus norvegicus 112-120 8878428-6 1996 Isoproterenol-stimulated cyclic AMP accumulation was reduced by IL-1beta at 24 h in trachea and lung tissues. Isoproterenol 0-13 interleukin 1 beta Rattus norvegicus 64-72 8878428-6 1996 Isoproterenol-stimulated cyclic AMP accumulation was reduced by IL-1beta at 24 h in trachea and lung tissues. Cyclic AMP 25-35 interleukin 1 beta Rattus norvegicus 64-72 8897830-3 1996 Removal of glucose from the media partially inhibited IL-1 beta-stimulated nitrite (NO2-) production [8.1 +/- 0.3 vs. 4.4 +/- 0.6 nmol. Glucose 11-18 interleukin 1 beta Rattus norvegicus 54-63 8897830-3 1996 Removal of glucose from the media partially inhibited IL-1 beta-stimulated nitrite (NO2-) production [8.1 +/- 0.3 vs. 4.4 +/- 0.6 nmol. Nitrites 75-82 interleukin 1 beta Rattus norvegicus 54-63 8897830-3 1996 Removal of glucose from the media partially inhibited IL-1 beta-stimulated nitrite (NO2-) production [8.1 +/- 0.3 vs. 4.4 +/- 0.6 nmol. Nitrogen Dioxide 84-87 interleukin 1 beta Rattus norvegicus 54-63 8897830-5 1996 The glycolytic inhibitor 2-deoxy-D-glucose (2-DG) completely inhibited IL-1 beta-stimulated NO2- production [0.7 +/- 0.5 nmol. Deoxyglucose 25-42 interleukin 1 beta Rattus norvegicus 71-80 8897830-5 1996 The glycolytic inhibitor 2-deoxy-D-glucose (2-DG) completely inhibited IL-1 beta-stimulated NO2- production [0.7 +/- 0.5 nmol. Deoxyglucose 44-48 interleukin 1 beta Rattus norvegicus 71-80 8897830-5 1996 The glycolytic inhibitor 2-deoxy-D-glucose (2-DG) completely inhibited IL-1 beta-stimulated NO2- production [0.7 +/- 0.5 nmol. Nitrogen Dioxide 92-95 interleukin 1 beta Rattus norvegicus 71-80 8828503-3 1996 We have previously reported that IL-1 beta enhances IL-6 release and phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC) in AP cells. Phosphatidylcholines 116-135 interleukin 1 beta Rattus norvegicus 33-42 8828503-3 1996 We have previously reported that IL-1 beta enhances IL-6 release and phospholipase A2 (PLA2)-mediated hydrolysis of phosphatidylcholine (PC) in AP cells. Phosphatidylcholines 137-139 interleukin 1 beta Rattus norvegicus 33-42 8828503-4 1996 Because lysophosphatidylcholine (LPC) may function as a second messenger for IL-1 beta, we have investigated the effects of exogenous LPC on IL-6 release from AP cells in vitro. Lysophosphatidylcholines 33-36 interleukin 1 beta Rattus norvegicus 77-86 8828503-12 1996 Hydrolysis of the structurally related choline-linked phospholipid sphingomyelin (SM) has been implicated in IL-1 beta action in certain cell types. Choline 39-46 interleukin 1 beta Rattus norvegicus 109-118 8828503-12 1996 Hydrolysis of the structurally related choline-linked phospholipid sphingomyelin (SM) has been implicated in IL-1 beta action in certain cell types. Phospholipids 54-66 interleukin 1 beta Rattus norvegicus 109-118 8828503-12 1996 Hydrolysis of the structurally related choline-linked phospholipid sphingomyelin (SM) has been implicated in IL-1 beta action in certain cell types. Sphingomyelins 67-80 interleukin 1 beta Rattus norvegicus 109-118 8828503-12 1996 Hydrolysis of the structurally related choline-linked phospholipid sphingomyelin (SM) has been implicated in IL-1 beta action in certain cell types. Sphingomyelins 82-84 interleukin 1 beta Rattus norvegicus 109-118 8828503-16 1996 In addition, H7 (20 microM) abolished the stimulation of IL-6 release by IL-1 beta (0.16-100 ng/mL). 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 13-15 interleukin 1 beta Rattus norvegicus 73-82 8894671-11 1996 Sera from Ad-IL-1ra athymic rats significantly inhibited IL-1 beta-induced (1 ng/ml) prostaglandin E2 (PGE2) production from cultured endothelial cells by 82 +/- 2% (p < 0.001). Dinoprostone 85-101 interleukin 1 beta Rattus norvegicus 57-66 8894671-11 1996 Sera from Ad-IL-1ra athymic rats significantly inhibited IL-1 beta-induced (1 ng/ml) prostaglandin E2 (PGE2) production from cultured endothelial cells by 82 +/- 2% (p < 0.001). Dinoprostone 103-107 interleukin 1 beta Rattus norvegicus 57-66 8891309-0 1996 Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1 beta: a possible site of prostaglandin synthesis responsible for fever. Prostaglandins 140-153 interleukin 1 beta Rattus norvegicus 101-119 9080247-10 1996 In vitro, sinomenine markedly inhibited proliferation of synovial fibroblasts from AIA or normal rats, both at rest and following activation with either transforming growth factor beta 2 (TGF-beta 2) or interleukin-1 beta (IL-1 beta). sinomenine 10-20 interleukin 1 beta Rattus norvegicus 203-221 9080247-10 1996 In vitro, sinomenine markedly inhibited proliferation of synovial fibroblasts from AIA or normal rats, both at rest and following activation with either transforming growth factor beta 2 (TGF-beta 2) or interleukin-1 beta (IL-1 beta). sinomenine 10-20 interleukin 1 beta Rattus norvegicus 223-232 8943779-4 1996 Exposure to interleukin-1 beta dose-dependently reduced iodine uptake in FRTL-5 cells, but had no effect on thyroglobulin secretion. Iodine 56-62 interleukin 1 beta Rattus norvegicus 12-30 8958563-2 1996 ET-1 inhibited the nitrite accumulation induced by a combination of interleukin-1 beta, tumor necrosis factor-alpha, and lipopolysaccharide in a concentration-dependent manner. Nitrites 19-26 interleukin 1 beta Rattus norvegicus 68-115 8915982-3 1996 Addition of the nitric oxide donors 3-morpholino-sydnonimine (SIN-1) or sodium nitroprusside significantly suppressed IL-1 beta-induced ICAM-1 molecule expression in a dose-dependent manner. Nitric Oxide 16-28 interleukin 1 beta Rattus norvegicus 118-127 8915982-3 1996 Addition of the nitric oxide donors 3-morpholino-sydnonimine (SIN-1) or sodium nitroprusside significantly suppressed IL-1 beta-induced ICAM-1 molecule expression in a dose-dependent manner. linsidomine 36-60 interleukin 1 beta Rattus norvegicus 118-127 8915982-3 1996 Addition of the nitric oxide donors 3-morpholino-sydnonimine (SIN-1) or sodium nitroprusside significantly suppressed IL-1 beta-induced ICAM-1 molecule expression in a dose-dependent manner. Linsidomine 62-67 interleukin 1 beta Rattus norvegicus 118-127 8915982-3 1996 Addition of the nitric oxide donors 3-morpholino-sydnonimine (SIN-1) or sodium nitroprusside significantly suppressed IL-1 beta-induced ICAM-1 molecule expression in a dose-dependent manner. Nitroprusside 72-92 interleukin 1 beta Rattus norvegicus 118-127 8915982-7 1996 These results suggest that nitric oxide suppresses ICAM-1 expression in IL-1 beta-stimulated mesangial cells, independent of cGMP formation. Nitric Oxide 27-39 interleukin 1 beta Rattus norvegicus 72-81 8891309-7 1996 These results imply that circulating IL-1 beta acts on its receptor on the endothelial cells of the brain vasculature to induce COX-2 mRNA, which is possibly responsible for the elevated level of PGE2 seen during fever. Dinoprostone 196-200 interleukin 1 beta Rattus norvegicus 37-46 8853359-6 1996 Contrastingly, a large dose-dependent decrease in reactivity to norepinephrine was found immediately after exposure to IL-1 beta and still persisted 100 min after the end of the exposure. Norepinephrine 64-78 interleukin 1 beta Rattus norvegicus 119-128 8884240-1 1996 We examined the influence of streptozotocin-induced diabetes on the growth of cultured rat aortic smooth muscle cells in the presence of interleukin-1 beta. Streptozocin 29-43 interleukin 1 beta Rattus norvegicus 137-155 8884240-2 1996 Interleukin-1 beta induced a dose-dependent biphasic effect on proliferation of diabetic and control smooth muscle cells, consistent with the data on [3H]thymidine incorporation and cell counts. Tritium 151-153 interleukin 1 beta Rattus norvegicus 0-18 8884240-2 1996 Interleukin-1 beta induced a dose-dependent biphasic effect on proliferation of diabetic and control smooth muscle cells, consistent with the data on [3H]thymidine incorporation and cell counts. Thymidine 154-163 interleukin 1 beta Rattus norvegicus 0-18 8884240-4 1996 Furthermore, interleukin-1 beta induced a dose-dependent increase in nitric oxide (NO) release and in intracellular cyclic GMP accumulation: nitrite release was similar in both smooth muscle cell models but cyclic GMP accumulation was greater in diabetic cells than in controls. Nitric Oxide 69-81 interleukin 1 beta Rattus norvegicus 13-31 8884240-4 1996 Furthermore, interleukin-1 beta induced a dose-dependent increase in nitric oxide (NO) release and in intracellular cyclic GMP accumulation: nitrite release was similar in both smooth muscle cell models but cyclic GMP accumulation was greater in diabetic cells than in controls. Cyclic GMP 116-126 interleukin 1 beta Rattus norvegicus 13-31 8884240-4 1996 Furthermore, interleukin-1 beta induced a dose-dependent increase in nitric oxide (NO) release and in intracellular cyclic GMP accumulation: nitrite release was similar in both smooth muscle cell models but cyclic GMP accumulation was greater in diabetic cells than in controls. Nitrites 141-148 interleukin 1 beta Rattus norvegicus 13-31 8884240-4 1996 Furthermore, interleukin-1 beta induced a dose-dependent increase in nitric oxide (NO) release and in intracellular cyclic GMP accumulation: nitrite release was similar in both smooth muscle cell models but cyclic GMP accumulation was greater in diabetic cells than in controls. Cyclic GMP 207-217 interleukin 1 beta Rattus norvegicus 13-31 8879343-4 1996 However, cGMP concentrations associated with IL-1 beta stimulation were significantly smaller in SHR VSMC than in cells from WKY. Cyclic GMP 9-13 interleukin 1 beta Rattus norvegicus 45-54 8879343-8 1996 Actinomycin-D completely blocked the induction of iNOS mRNA by IL-1 beta in cells from both strains of rats, whereas cycloheximide partially blocked its synthesis in WKY, but had no significant effect on IL-1 beta induced expression of iNOS mRNA in SHR VSMC. Dactinomycin 0-13 interleukin 1 beta Rattus norvegicus 63-72 8930985-4 1996 After 24 hours incubation with either tumor necrosis factors alpha (TNF-alpha), interferon gamma (IFN-gamma) or interleukin-1 beta (IL-1 beta), astrocytic glutamate uptake was markedly attenuated in a dose-dependent manner. Glutamic Acid 155-164 interleukin 1 beta Rattus norvegicus 112-130 8930985-4 1996 After 24 hours incubation with either tumor necrosis factors alpha (TNF-alpha), interferon gamma (IFN-gamma) or interleukin-1 beta (IL-1 beta), astrocytic glutamate uptake was markedly attenuated in a dose-dependent manner. Glutamic Acid 155-164 interleukin 1 beta Rattus norvegicus 132-141 8853359-10 1996 2) Short exposure to IL-1 beta but not to rhTNF or IL-6 diminishes the response of the arterioles to norepinephrine but not to KCl. Norepinephrine 101-115 interleukin 1 beta Rattus norvegicus 21-30 8879343-9 1996 Thus, IL-1 beta controls iNOS gene expression at the transcriptional level, and an intermediate labile protein, whose synthesis is inhibited by cycloheximide, is required for IL-1 beta stimulated induction of iNOS mRNA transcription in WKY cells but not in SHR. Cycloheximide 144-157 interleukin 1 beta Rattus norvegicus 175-184 8809061-7 1996 In the present paper we demonstrate that IL-1 beta and cAMP similarly increase the steady-state mRNA levels of GTP cyclohydrolase I (EC 3,5,4,16), the rate-limiting enzyme in BH4 biosynthesis, as measured by a sensitive and quantitative nuclease protection assay. sapropterin 175-178 interleukin 1 beta Rattus norvegicus 41-50 8809061-11 1996 Furthermore, IL-1 beta and cAMP led to a marked increase in GTP cyclohydrolase I activity and to increased accumulation of biopterin in mesangial cells. Biopterin 123-132 interleukin 1 beta Rattus norvegicus 13-22 8809061-10 1996 Moreover, cAMP exposure markedly prolonged the half-life of GTP cyclohydrolase I mRNA, from 1.5 to 3.4 h. In a next step we generated a rabbit polyclonal antibody against rat GTP cyclohydrolase I expressed in Escherichia coli and demonstrated that IL-1 beta and cAMP elevated GTP cyclohydrolase I protein levels in mesangial cells. Cyclic AMP 10-14 interleukin 1 beta Rattus norvegicus 248-257 8954594-0 1996 Effects of fetal alcohol exposure on fever, sickness behavior, and pituitary-adrenal activation induced by interleukin-1 beta in young adult rats. Alcohols 17-24 interleukin 1 beta Rattus norvegicus 107-125 8756547-2 1996 The purpose of this experiment was to determine whether interleukin-1 beta (IL-1 beta), a known modulator of MMPI expression in other systems and one that is induced by LH in the ovary, is capable of regulating granulosa matrix metalloproteinase inhibitor expression and activity. Luteinizing Hormone 169-171 interleukin 1 beta Rattus norvegicus 56-74 8756547-2 1996 The purpose of this experiment was to determine whether interleukin-1 beta (IL-1 beta), a known modulator of MMPI expression in other systems and one that is induced by LH in the ovary, is capable of regulating granulosa matrix metalloproteinase inhibitor expression and activity. Luteinizing Hormone 169-171 interleukin 1 beta Rattus norvegicus 76-85 8756547-12 1996 In addition, an increase in progesterone production was associated with IL-1 beta-stimulated (1.22-fold over control values; P = 0.0006) and LH-stimulated (9.6-fold over control values; P = 0.007) MMPI expression and activity. Progesterone 28-40 interleukin 1 beta Rattus norvegicus 72-81 8754764-0 1996 Epiandrosterone and dehydroepiandrosterone affect glucose oxidation and interleukin-1 beta effects in pancreatic islets. Androsterone 0-15 interleukin 1 beta Rattus norvegicus 72-90 8894440-2 1996 Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 beta) or human islets exposed to IL-1 beta + tumour necrosis factor alpha (TNF-alpha) + interferon gamma (IFN-gamma). Citrulline 0-10 interleukin 1 beta Rattus norvegicus 135-153 8894440-2 1996 Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 beta) or human islets exposed to IL-1 beta + tumour necrosis factor alpha (TNF-alpha) + interferon gamma (IFN-gamma). Citrulline 0-10 interleukin 1 beta Rattus norvegicus 155-164 8894440-2 1996 Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 beta) or human islets exposed to IL-1 beta + tumour necrosis factor alpha (TNF-alpha) + interferon gamma (IFN-gamma). Arginine 27-35 interleukin 1 beta Rattus norvegicus 135-153 8894440-2 1996 Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 beta) or human islets exposed to IL-1 beta + tumour necrosis factor alpha (TNF-alpha) + interferon gamma (IFN-gamma). Arginine 27-35 interleukin 1 beta Rattus norvegicus 155-164 8780572-2 1996 It is postulated that leukemia inhibitory factor (LIF), the downstream intermediate of several IL-1-induced neuroimmune interactions, mediates IL-1 beta-induced suppression of acetylcholine release from rat jejunum. Acetylcholine 176-189 interleukin 1 beta Rattus norvegicus 143-152 8780572-7 1996 Human recombinant IL-1 beta (10 ng/mL) induced a similar suppression of acetylcholine release, and the addition of anti-rat LIF antibody abolished the effects of exogenous IL-1 on acetylcholine release. Acetylcholine 72-85 interleukin 1 beta Rattus norvegicus 18-27 8949656-0 1996 Inhibition of acetylcholine induced intestinal motility by interleukin 1 beta in the rat. Acetylcholine 14-27 interleukin 1 beta Rattus norvegicus 59-77 8949656-5 1996 RESULTS: Although IL 1 beta did not affect jejunal, ileal, and colonic basal contractility, it significantly reduced contractile response to acetylcholine (ACh). Acetylcholine 141-154 interleukin 1 beta Rattus norvegicus 18-27 8949656-5 1996 RESULTS: Although IL 1 beta did not affect jejunal, ileal, and colonic basal contractility, it significantly reduced contractile response to acetylcholine (ACh). Acetylcholine 156-159 interleukin 1 beta Rattus norvegicus 18-27 8949656-7 1996 Pretreatment with cycloheximide blocked IL 1 beta induced inhibition of ACh stimulated jejunal contraction, suggesting that a newly synthesised protein was involved in the effect. Cycloheximide 18-31 interleukin 1 beta Rattus norvegicus 40-49 8949656-7 1996 Pretreatment with cycloheximide blocked IL 1 beta induced inhibition of ACh stimulated jejunal contraction, suggesting that a newly synthesised protein was involved in the effect. Acetylcholine 72-75 interleukin 1 beta Rattus norvegicus 40-49 8949656-9 1996 Blocking neural transmission with tetrodotoxin abolished the IL 1 beta effect on jejunal contractile activity, whereas IL 1 beta had no effect on isolated and dispersed smooth muscle cells. Tetrodotoxin 34-46 interleukin 1 beta Rattus norvegicus 61-70 8949656-10 1996 CONCLUSIONS: IL 1 beta inhibits ACh induced intestinal contraction and this inhibitory effect involves protein synthesis but is independent of nitric oxide synthesis. Acetylcholine 32-35 interleukin 1 beta Rattus norvegicus 13-22 8949656-10 1996 CONCLUSIONS: IL 1 beta inhibits ACh induced intestinal contraction and this inhibitory effect involves protein synthesis but is independent of nitric oxide synthesis. Nitric Oxide 143-155 interleukin 1 beta Rattus norvegicus 13-22 8770043-7 1996 In light of the well-established gastroprotection exerted by IL-1, H(+)-induced IL-1 beta release might serve as a protection against mucosal injuries caused by acid secretion, and the inhibition of this release by glucocorticoids might be involved in the pathogenesis of gastric damage associated with severe stress or steroid therapy. Steroids 320-327 interleukin 1 beta Rattus norvegicus 80-89 8760354-8 1996 Inhibition of GAD65 and GAD67 protein synthesis by IL-1 beta, TNF-alpha or IFN-gamma was reversed by co-incubation with the nitric oxide synthase inhibitor, NG-monomethyl arginine (NMMA). ng-monomethyl arginine 157-179 interleukin 1 beta Rattus norvegicus 51-60 8760354-8 1996 Inhibition of GAD65 and GAD67 protein synthesis by IL-1 beta, TNF-alpha or IFN-gamma was reversed by co-incubation with the nitric oxide synthase inhibitor, NG-monomethyl arginine (NMMA). nmma 181-185 interleukin 1 beta Rattus norvegicus 51-60 8842423-0 1996 Inhibition by tetranactin of interleukin 1 beta- and cyclic AMP-induced nitric oxide synthase expression in rat renal mesangial cells. tetranactin 14-25 interleukin 1 beta Rattus norvegicus 29-47 8842423-5 1996 Treatment of mesangial cells with IL-1 beta or the membrane-permeable cyclic AMP analogue, N6, 0-2"-dibutyryladenosine 3",5"-phosphate (Bt2 cyclic AMP) for 24 h induces iNOS activity measured as nitrite levels in cell culture supernatants by 44 fold or 33 fold, respectively. bt2 cyclic amp 136-150 interleukin 1 beta Rattus norvegicus 34-43 8842423-5 1996 Treatment of mesangial cells with IL-1 beta or the membrane-permeable cyclic AMP analogue, N6, 0-2"-dibutyryladenosine 3",5"-phosphate (Bt2 cyclic AMP) for 24 h induces iNOS activity measured as nitrite levels in cell culture supernatants by 44 fold or 33 fold, respectively. Nitrites 195-202 interleukin 1 beta Rattus norvegicus 34-43 8842423-6 1996 Incubation of mesangial cells with tetranactin inhibits IL-1 beta- and cyclic AMP-dependent production of nitrite in a dose-dependent fashion with IC50 values of 50 nM and 10 nM, respectively. tetranactin 35-46 interleukin 1 beta Rattus norvegicus 56-65 8842423-6 1996 Incubation of mesangial cells with tetranactin inhibits IL-1 beta- and cyclic AMP-dependent production of nitrite in a dose-dependent fashion with IC50 values of 50 nM and 10 nM, respectively. Nitrites 106-113 interleukin 1 beta Rattus norvegicus 56-65 8894440-5 1996 Studies of IL-1 beta exposed rat islets revealed both NO-dependent and NO-independent effects: (1) IL-1 beta inhibits glucose-induced insulin release even in the absence of NO synthesis, but this inhibition is more severe when the presence of citrulline or arginine enables NO production; (2) NO formation in the presence of arginine or citrulline is necessary for cytokine-induced inhibition of protein biosynthesis. Glucose 118-125 interleukin 1 beta Rattus norvegicus 99-108 8894440-5 1996 Studies of IL-1 beta exposed rat islets revealed both NO-dependent and NO-independent effects: (1) IL-1 beta inhibits glucose-induced insulin release even in the absence of NO synthesis, but this inhibition is more severe when the presence of citrulline or arginine enables NO production; (2) NO formation in the presence of arginine or citrulline is necessary for cytokine-induced inhibition of protein biosynthesis. Arginine 257-265 interleukin 1 beta Rattus norvegicus 99-108 8894440-5 1996 Studies of IL-1 beta exposed rat islets revealed both NO-dependent and NO-independent effects: (1) IL-1 beta inhibits glucose-induced insulin release even in the absence of NO synthesis, but this inhibition is more severe when the presence of citrulline or arginine enables NO production; (2) NO formation in the presence of arginine or citrulline is necessary for cytokine-induced inhibition of protein biosynthesis. Arginine 325-333 interleukin 1 beta Rattus norvegicus 99-108 8894440-5 1996 Studies of IL-1 beta exposed rat islets revealed both NO-dependent and NO-independent effects: (1) IL-1 beta inhibits glucose-induced insulin release even in the absence of NO synthesis, but this inhibition is more severe when the presence of citrulline or arginine enables NO production; (2) NO formation in the presence of arginine or citrulline is necessary for cytokine-induced inhibition of protein biosynthesis. Citrulline 337-347 interleukin 1 beta Rattus norvegicus 99-108 21153094-8 1996 Adrenergic mechanisms may be involved in this differential effect on oxytocin release in lactation as phentolamine pretreatment attenuated IL-1beta-induced oxytocin release in early lactation and reversed the depression in IL-1beta-stimulation of oxytocin release observed in late lactation. Phentolamine 102-114 interleukin 1 beta Rattus norvegicus 139-147 21153094-8 1996 Adrenergic mechanisms may be involved in this differential effect on oxytocin release in lactation as phentolamine pretreatment attenuated IL-1beta-induced oxytocin release in early lactation and reversed the depression in IL-1beta-stimulation of oxytocin release observed in late lactation. Phentolamine 102-114 interleukin 1 beta Rattus norvegicus 223-231 8754764-0 1996 Epiandrosterone and dehydroepiandrosterone affect glucose oxidation and interleukin-1 beta effects in pancreatic islets. Dehydroepiandrosterone 20-42 interleukin 1 beta Rattus norvegicus 72-90 8754764-1 1996 Isolated rat islets or RINm5F insulinoma cells treated with interleukin-1 beta (IL-1 beta) for 18 h show reduced glucose-sensitive insulin release and increased nitrite formation as a result of nitric oxide synthase induction. Glucose 113-120 interleukin 1 beta Rattus norvegicus 60-78 8754764-1 1996 Isolated rat islets or RINm5F insulinoma cells treated with interleukin-1 beta (IL-1 beta) for 18 h show reduced glucose-sensitive insulin release and increased nitrite formation as a result of nitric oxide synthase induction. Glucose 113-120 interleukin 1 beta Rattus norvegicus 80-89 8754764-1 1996 Isolated rat islets or RINm5F insulinoma cells treated with interleukin-1 beta (IL-1 beta) for 18 h show reduced glucose-sensitive insulin release and increased nitrite formation as a result of nitric oxide synthase induction. Nitrites 161-168 interleukin 1 beta Rattus norvegicus 60-78 8754764-1 1996 Isolated rat islets or RINm5F insulinoma cells treated with interleukin-1 beta (IL-1 beta) for 18 h show reduced glucose-sensitive insulin release and increased nitrite formation as a result of nitric oxide synthase induction. Nitrites 161-168 interleukin 1 beta Rattus norvegicus 80-89 8754764-3 1996 Islets that were cultured for 18 h in the presence of IL-1 beta and epiandrosterone (EA) or dehydroepiandrosterone (DHEA) and then washed responded with a concentration-dependent reversal of the effects of IL-1 beta on insulin release in the presence of a glucose or glucose plus isobutylmethylxanthine stimulus. Androsterone 68-83 interleukin 1 beta Rattus norvegicus 206-215 8754764-3 1996 Islets that were cultured for 18 h in the presence of IL-1 beta and epiandrosterone (EA) or dehydroepiandrosterone (DHEA) and then washed responded with a concentration-dependent reversal of the effects of IL-1 beta on insulin release in the presence of a glucose or glucose plus isobutylmethylxanthine stimulus. Androsterone 85-87 interleukin 1 beta Rattus norvegicus 54-63 8754764-3 1996 Islets that were cultured for 18 h in the presence of IL-1 beta and epiandrosterone (EA) or dehydroepiandrosterone (DHEA) and then washed responded with a concentration-dependent reversal of the effects of IL-1 beta on insulin release in the presence of a glucose or glucose plus isobutylmethylxanthine stimulus. Androsterone 85-87 interleukin 1 beta Rattus norvegicus 206-215 8754764-3 1996 Islets that were cultured for 18 h in the presence of IL-1 beta and epiandrosterone (EA) or dehydroepiandrosterone (DHEA) and then washed responded with a concentration-dependent reversal of the effects of IL-1 beta on insulin release in the presence of a glucose or glucose plus isobutylmethylxanthine stimulus. Dehydroepiandrosterone 92-114 interleukin 1 beta Rattus norvegicus 206-215 8754764-3 1996 Islets that were cultured for 18 h in the presence of IL-1 beta and epiandrosterone (EA) or dehydroepiandrosterone (DHEA) and then washed responded with a concentration-dependent reversal of the effects of IL-1 beta on insulin release in the presence of a glucose or glucose plus isobutylmethylxanthine stimulus. Dehydroepiandrosterone 116-120 interleukin 1 beta Rattus norvegicus 206-215 8754764-3 1996 Islets that were cultured for 18 h in the presence of IL-1 beta and epiandrosterone (EA) or dehydroepiandrosterone (DHEA) and then washed responded with a concentration-dependent reversal of the effects of IL-1 beta on insulin release in the presence of a glucose or glucose plus isobutylmethylxanthine stimulus. Glucose 256-263 interleukin 1 beta Rattus norvegicus 54-63 8754764-3 1996 Islets that were cultured for 18 h in the presence of IL-1 beta and epiandrosterone (EA) or dehydroepiandrosterone (DHEA) and then washed responded with a concentration-dependent reversal of the effects of IL-1 beta on insulin release in the presence of a glucose or glucose plus isobutylmethylxanthine stimulus. Glucose 256-263 interleukin 1 beta Rattus norvegicus 206-215 8754764-3 1996 Islets that were cultured for 18 h in the presence of IL-1 beta and epiandrosterone (EA) or dehydroepiandrosterone (DHEA) and then washed responded with a concentration-dependent reversal of the effects of IL-1 beta on insulin release in the presence of a glucose or glucose plus isobutylmethylxanthine stimulus. Glucose 267-274 interleukin 1 beta Rattus norvegicus 54-63 8754764-3 1996 Islets that were cultured for 18 h in the presence of IL-1 beta and epiandrosterone (EA) or dehydroepiandrosterone (DHEA) and then washed responded with a concentration-dependent reversal of the effects of IL-1 beta on insulin release in the presence of a glucose or glucose plus isobutylmethylxanthine stimulus. Glucose 267-274 interleukin 1 beta Rattus norvegicus 206-215 8754764-3 1996 Islets that were cultured for 18 h in the presence of IL-1 beta and epiandrosterone (EA) or dehydroepiandrosterone (DHEA) and then washed responded with a concentration-dependent reversal of the effects of IL-1 beta on insulin release in the presence of a glucose or glucose plus isobutylmethylxanthine stimulus. 1-Methyl-3-isobutylxanthine 280-302 interleukin 1 beta Rattus norvegicus 54-63 8754764-3 1996 Islets that were cultured for 18 h in the presence of IL-1 beta and epiandrosterone (EA) or dehydroepiandrosterone (DHEA) and then washed responded with a concentration-dependent reversal of the effects of IL-1 beta on insulin release in the presence of a glucose or glucose plus isobutylmethylxanthine stimulus. 1-Methyl-3-isobutylxanthine 280-302 interleukin 1 beta Rattus norvegicus 206-215 8754764-5 1996 Nitrite formation in islets and RINm5F cells in response to IL-1 beta was also significantly reduced during culture with EA or DHEA, although nitrite levels were still elevated above control values. Nitrites 0-7 interleukin 1 beta Rattus norvegicus 60-69 8754764-5 1996 Nitrite formation in islets and RINm5F cells in response to IL-1 beta was also significantly reduced during culture with EA or DHEA, although nitrite levels were still elevated above control values. Androsterone 121-123 interleukin 1 beta Rattus norvegicus 60-69 8754764-5 1996 Nitrite formation in islets and RINm5F cells in response to IL-1 beta was also significantly reduced during culture with EA or DHEA, although nitrite levels were still elevated above control values. Dehydroepiandrosterone 127-131 interleukin 1 beta Rattus norvegicus 60-69 8754764-7 1996 Pyrrolidine dithiocarbamate also reduced IL-1 beta-induced nitrite formation. pyrrolidine dithiocarbamic acid 0-27 interleukin 1 beta Rattus norvegicus 41-50 8854248-8 1996 When the effect of IL-1 beta was examined, it was observed that this cytokine inhibited [3H]-thymidine incorporation by resting zone cells and stimulated isotope incorporation in growth zone cells. Tritium 89-91 interleukin 1 beta Rattus norvegicus 19-28 8754764-7 1996 Pyrrolidine dithiocarbamate also reduced IL-1 beta-induced nitrite formation. Nitrites 59-66 interleukin 1 beta Rattus norvegicus 41-50 8854248-8 1996 When the effect of IL-1 beta was examined, it was observed that this cytokine inhibited [3H]-thymidine incorporation by resting zone cells and stimulated isotope incorporation in growth zone cells. Thymidine 93-102 interleukin 1 beta Rattus norvegicus 19-28 8754764-13 1996 Thus, EA and DHEA antagonize the effects of IL-1 beta on beta-cells. Androsterone 6-8 interleukin 1 beta Rattus norvegicus 44-53 8854248-9 1996 IL-1 beta also stimulated alkaline phosphatase specific activity and inhibited [35S]-sulfate incorporation by resting zone chondrocytes but had no affect on growth zone chondrocytes. 35s]-sulfate 80-92 interleukin 1 beta Rattus norvegicus 0-9 8754764-13 1996 Thus, EA and DHEA antagonize the effects of IL-1 beta on beta-cells. Dehydroepiandrosterone 13-17 interleukin 1 beta Rattus norvegicus 44-53 8764661-7 1996 This enhancement of the peptide release by LPS was blocked by IL-1beta tripeptide antagonist Lys-D-Pro-Thr (10 microM) and mimicked by IL-1beta and TNF-alpha (10-100 pg/ml), suggesting that the potentiating effect of LPS on CGRP release is mediated by generation of IL-1beta and TNF-alpha. tripeptide K-26 71-81 interleukin 1 beta Rattus norvegicus 62-70 8764661-9 1996 Additionally, the cyclooxygenase inhibitor ketorolac (10 microM) significantly attenuated the facilitatory effects of LPS and IL-1b, indicating involvement of prostanoids. Ketorolac 43-52 interleukin 1 beta Rattus norvegicus 126-131 8764661-9 1996 Additionally, the cyclooxygenase inhibitor ketorolac (10 microM) significantly attenuated the facilitatory effects of LPS and IL-1b, indicating involvement of prostanoids. Prostaglandins 159-170 interleukin 1 beta Rattus norvegicus 126-131 8864489-14 1996 IL-1 beta; (2) stimulation of corticosterone secretion by i.p. Corticosterone 30-44 interleukin 1 beta Rattus norvegicus 0-9 8713078-1 1996 Treatment of cultured hepatocytes with a combination of cytokines, including tumour necrosis factor-alpha, interferon-gamma and interleukin-1 beta, plus lipopolysaccharide resulted in a time-dependent induction of nitric oxide (NO) synthase (as measured by NO2- (+) NO3- production) and inhibition of hepatic gluconeogenesis and glycogen breakdown. Nitric Oxide 214-226 interleukin 1 beta Rattus norvegicus 128-146 8713078-1 1996 Treatment of cultured hepatocytes with a combination of cytokines, including tumour necrosis factor-alpha, interferon-gamma and interleukin-1 beta, plus lipopolysaccharide resulted in a time-dependent induction of nitric oxide (NO) synthase (as measured by NO2- (+) NO3- production) and inhibition of hepatic gluconeogenesis and glycogen breakdown. no2- (+) no3 257-269 interleukin 1 beta Rattus norvegicus 128-146 8713078-1 1996 Treatment of cultured hepatocytes with a combination of cytokines, including tumour necrosis factor-alpha, interferon-gamma and interleukin-1 beta, plus lipopolysaccharide resulted in a time-dependent induction of nitric oxide (NO) synthase (as measured by NO2- (+) NO3- production) and inhibition of hepatic gluconeogenesis and glycogen breakdown. Glycogen 329-337 interleukin 1 beta Rattus norvegicus 128-146 8760140-4 1996 Stimulation with IL-1 beta and TNF-alpha plus H2O2 or IL-1 beta and LPS plus H2O2 increased the synthesis of NO2- and NO3- by 3.8- and 3.5-fold, respectively. Nitrogen Dioxide 109-112 interleukin 1 beta Rattus norvegicus 17-26 8760074-1 1996 We have previously reported that interleukin-1 beta (IL-1) alone induced the transcription of inducible nitric oxide synthase (iNOS) mRNA and nitric oxide (NO) production by isolated neonatal rat cardiac myocytes (CM). Nitric Oxide 104-116 interleukin 1 beta Rattus norvegicus 33-51 8755646-10 1996 Group II PLA2 activity of glomerular mesangial cells stimulated by interleukin-1 beta was enhanced by bile juice and various bile salts. Bile Acids and Salts 125-135 interleukin 1 beta Rattus norvegicus 67-85 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitric Oxide 202-214 interleukin 1 beta Rattus norvegicus 66-84 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrites 253-260 interleukin 1 beta Rattus norvegicus 66-84 8760147-13 1996 IL-1 beta-mediated increases in steady-state iNOS mRNA were sensitive to pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappa B activation. pyrrolidine dithiocarbamic acid 73-100 interleukin 1 beta Rattus norvegicus 0-9 8760140-4 1996 Stimulation with IL-1 beta and TNF-alpha plus H2O2 or IL-1 beta and LPS plus H2O2 increased the synthesis of NO2- and NO3- by 3.8- and 3.5-fold, respectively. Nitrogen Dioxide 109-112 interleukin 1 beta Rattus norvegicus 54-63 8760147-14 1996 Nuclear proteins from IL-1 beta-stimulated cells demonstrated PDTC-sensitive binding to an oligonucleotide containing the sequence for the NF-kappa B binding element present in the region between -242 and -42 bp. Oligonucleotides 91-106 interleukin 1 beta Rattus norvegicus 22-31 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrogen Dioxide 262-265 interleukin 1 beta Rattus norvegicus 66-84 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrates 272-279 interleukin 1 beta Rattus norvegicus 66-84 8760140-4 1996 Stimulation with IL-1 beta and TNF-alpha plus H2O2 or IL-1 beta and LPS plus H2O2 increased the synthesis of NO2- and NO3- by 3.8- and 3.5-fold, respectively. punky blue 118-121 interleukin 1 beta Rattus norvegicus 17-26 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). punky blue 281-284 interleukin 1 beta Rattus norvegicus 66-84 8760140-4 1996 Stimulation with IL-1 beta and TNF-alpha plus H2O2 or IL-1 beta and LPS plus H2O2 increased the synthesis of NO2- and NO3- by 3.8- and 3.5-fold, respectively. punky blue 118-121 interleukin 1 beta Rattus norvegicus 54-63 8841941-3 1996 Addition of phenylephrine significantly augmented nitrite production by IL-1 beta-stimulated but not by unstimulated myocytes in a dose-dependent manner. Nitrites 50-57 interleukin 1 beta Rattus norvegicus 72-81 8690044-6 1996 Consistent with these findings, PGE2 production elicited by IL-1beta or IL-1-rich supernatants in the rat long-bone assay was abolished by each reagent. Dinoprostone 32-36 interleukin 1 beta Rattus norvegicus 60-68 8841941-2 1996 Incubation of cultured neonatal rat cardiac myocytes with interleukin-1 beta (IL-1 beta) caused a significant increase in the production of nitrite, a stable metabolite of NO. Nitrites 140-147 interleukin 1 beta Rattus norvegicus 58-76 8841941-5 1996 Northern blotting revealed increased inducible NO synthase mRNA accumulation in cardiac myocytes treated with IL-1 beta and phenylephrine compared with those treated with IL-1 beta alone. Phenylephrine 124-137 interleukin 1 beta Rattus norvegicus 171-180 8841941-2 1996 Incubation of cultured neonatal rat cardiac myocytes with interleukin-1 beta (IL-1 beta) caused a significant increase in the production of nitrite, a stable metabolite of NO. Nitrites 140-147 interleukin 1 beta Rattus norvegicus 78-87 9094442-9 1996 In fact, the addition of AP5 before anoxic exposure resulted in a significant increase of cellular survival, but also in a decrease of IL-1beta release and a re-establishment of IL-1beta and IFN-gamma release relations to the initial condition without stress. 2-amino-5-phosphopentanoic acid 25-28 interleukin 1 beta Rattus norvegicus 135-143 8841941-3 1996 Addition of phenylephrine significantly augmented nitrite production by IL-1 beta-stimulated but not by unstimulated myocytes in a dose-dependent manner. Phenylephrine 12-25 interleukin 1 beta Rattus norvegicus 72-81 8807588-11 1996 Treatment of the animals with PGE1 inhibited the mRNA expression of TGF-beta and IL-1 beta. Alprostadil 30-34 interleukin 1 beta Rattus norvegicus 81-90 8807588-13 1996 The effects of PGE1 might be mediated by inhibition of TGF-beta and IL-1 beta production. Alprostadil 15-19 interleukin 1 beta Rattus norvegicus 68-77 9094448-5 1996 These results may suggest a dissociative regulation by gonadal steroids of IL-1beta- and immobilization-induced ACTH responses in the rat. Steroids 63-71 interleukin 1 beta Rattus norvegicus 75-83 8832057-0 1996 Downregulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin-1 beta. Cyclic GMP 43-53 interleukin 1 beta Rattus norvegicus 100-118 8832057-4 1996 The aim of the present study was to investigate the activation of sGC by sodium nitroprusside (SNP) before and after exposure of rat aortic smooth muscle cells to endotoxin (LPS) or interleukin-1 beta (IL-1 beta). Nitroprusside 73-93 interleukin 1 beta Rattus norvegicus 202-211 8832057-13 1996 The IL-1 beta-induced reduction in SNP-stimulated cyclic GMP accumulation in cultured cells was dependent on NO production, as arginine depletion abolished the downregulation of cyclic GMP accumulation in response to SNP. Cyclic GMP 50-60 interleukin 1 beta Rattus norvegicus 4-13 8832057-13 1996 The IL-1 beta-induced reduction in SNP-stimulated cyclic GMP accumulation in cultured cells was dependent on NO production, as arginine depletion abolished the downregulation of cyclic GMP accumulation in response to SNP. Arginine 127-135 interleukin 1 beta Rattus norvegicus 4-13 8832057-13 1996 The IL-1 beta-induced reduction in SNP-stimulated cyclic GMP accumulation in cultured cells was dependent on NO production, as arginine depletion abolished the downregulation of cyclic GMP accumulation in response to SNP. Cyclic GMP 178-188 interleukin 1 beta Rattus norvegicus 4-13 8832057-17 1996 Protein levels of the alpha 1 sGC subunit remained unaltered upon exposure to LPS or IL-1 beta, suggesting that the early decreased cyclic GMP accumulation in IL-1 beta- or LPS-pretreated cells was probably due to reduced sGC activation. Cyclic GMP 132-142 interleukin 1 beta Rattus norvegicus 159-168 9094442-9 1996 In fact, the addition of AP5 before anoxic exposure resulted in a significant increase of cellular survival, but also in a decrease of IL-1beta release and a re-establishment of IL-1beta and IFN-gamma release relations to the initial condition without stress. 2-amino-5-phosphopentanoic acid 25-28 interleukin 1 beta Rattus norvegicus 178-186 9275497-0 1996 [The protective effect of nicotinamide on interleukin-1 beta induced damage to rat islets of Langerhans and its mechanism]. Niacinamide 26-38 interleukin 1 beta Rattus norvegicus 42-60 9275497-4 1996 25 mmol/L of NA reduced the inhibition of accumulated insulin release and 3H-thymidine incorporation induced by 40/ml of IL-1 beta. 3h-thymidine 74-86 interleukin 1 beta Rattus norvegicus 121-130 8813618-5 1996 Interleukin-1 beta (10-100 ng/ml) and fibroblast growth factor-2 (FGF-2; 50 ng/ml) were clearly effective when administered 24 h prior to the NMDA exposure, but not when given 60 min before the insult. N-Methylaspartate 142-146 interleukin 1 beta Rattus norvegicus 0-18 8663145-3 1996 Additionally, the nuclear complex specifically binding to the APPkappaB sites is constitutively expressed in primary neurons from rat cerebellum and it is up-regulated in response to both the inflammatory cytokine interleukin-1beta (IL-1beta) and the excitatory amino acid glutamate. Glutamic Acid 273-282 interleukin 1 beta Rattus norvegicus 214-231 8635652-3 1996 Furthermore, IL-1 beta induced higher islet iNOS mRNA expression and nitric oxide production from WK/Mol islets compared with BN/CR islets. Nitric Oxide 69-81 interleukin 1 beta Rattus norvegicus 13-22 8635652-5 1996 All the strains investigated were susceptible to IL-1 beta-induced changes in body weight, food intake, temperature, and plasma glucagon and corticosterone. Glucagon 128-136 interleukin 1 beta Rattus norvegicus 49-58 8635652-5 1996 All the strains investigated were susceptible to IL-1 beta-induced changes in body weight, food intake, temperature, and plasma glucagon and corticosterone. Corticosterone 141-155 interleukin 1 beta Rattus norvegicus 49-58 8635652-6 1996 However, IL-1 beta induced hyperglycemia and impairment of beta-cell glucose responsiveness in WK/Mol and LS/Mol rats, but not in BN rats. Glucose 69-76 interleukin 1 beta Rattus norvegicus 9-18 8635652-9 1996 In conclusion, the relative resistance of BN rat islets to IL-1 beta-induced inhibition of beta-cell function in vitro was associated with lower islet iNOS mRNA expression and nitrite production in this strain. Nitrites 176-183 interleukin 1 beta Rattus norvegicus 59-68 8672550-6 1996 Pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappa B activation, inhibited the NTS-induced increase of glomerular NF-kappa B DNA-binding activity, followed by the inhibition of mRNA expression of IL-1 beta, MCP-1, ICAM-1 and iNOS, which are known to be regulated by NF-kappa B. PDTC also prevented urinary protein excretion which is a pathophysiological parameter for glomerulonephritis. pyrrolidine dithiocarbamic acid 0-27 interleukin 1 beta Rattus norvegicus 212-221 8672550-6 1996 Pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappa B activation, inhibited the NTS-induced increase of glomerular NF-kappa B DNA-binding activity, followed by the inhibition of mRNA expression of IL-1 beta, MCP-1, ICAM-1 and iNOS, which are known to be regulated by NF-kappa B. PDTC also prevented urinary protein excretion which is a pathophysiological parameter for glomerulonephritis. pyrrolidine dithiocarbamic acid 29-33 interleukin 1 beta Rattus norvegicus 212-221 8672550-6 1996 Pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-kappa B activation, inhibited the NTS-induced increase of glomerular NF-kappa B DNA-binding activity, followed by the inhibition of mRNA expression of IL-1 beta, MCP-1, ICAM-1 and iNOS, which are known to be regulated by NF-kappa B. PDTC also prevented urinary protein excretion which is a pathophysiological parameter for glomerulonephritis. nts 95-98 interleukin 1 beta Rattus norvegicus 212-221 8635652-0 1996 Strain-dependent differences in sensitivity of rat beta-cells to interleukin 1 beta in vitro and in vivo: association with islet nitric oxide synthesis. Nitric Oxide 129-141 interleukin 1 beta Rattus norvegicus 65-83 8635652-1 1996 The aim of this study was to investigate whether strain-dependent differences in beta-cell sensitivity to interleukin (IL) 1 beta exist in vitro and in vivo and if so, whether these differences correlate to variations in IL-1 beta-induced islet inducible nitric oxide synthase (iNOS) mRNA expression and nitrite production in vitro and islet iNOS protein content in vivo. Nitrites 304-311 interleukin 1 beta Rattus norvegicus 221-230 8813640-0 1996 Tetranactin inhibits interleukin 1 beta and cAMP induction of group II phospholipase A2 in rat renal mesangial cells. tetranactin 0-11 interleukin 1 beta Rattus norvegicus 21-39 8675173-6 1996 In vitro endocytosis assays showed that rat HSE uptake of 125I-mannan or 125I-invertase progressively increased with both exposure time and concentration of added IL-1beta. 125i-mannan 58-69 interleukin 1 beta Rattus norvegicus 163-171 8813640-3 1996 Treatment of mesangial cells with tetranactin, a cyclic antibiotic produced by Streptomyces aureus with a molecular structure similar to cyclosporin A inhibits interleukin 1 beta- and cAMP-dependent group II phospholipase A2 secretion in a dose-dependent manner with IC50 values of 43 and 33 nM, respectively. tetranactin 34-45 interleukin 1 beta Rattus norvegicus 160-178 8813640-3 1996 Treatment of mesangial cells with tetranactin, a cyclic antibiotic produced by Streptomyces aureus with a molecular structure similar to cyclosporin A inhibits interleukin 1 beta- and cAMP-dependent group II phospholipase A2 secretion in a dose-dependent manner with IC50 values of 43 and 33 nM, respectively. Cyclosporine 137-150 interleukin 1 beta Rattus norvegicus 160-178 8658961-0 1996 A bacteria-expressed mouse interleukin-1 receptor antagonist peptide protects alginate-poly-L-lysine-alginate microencapsulated rat islets against the suppressive effect of interleukin-1 beta in vitro. Alginates 78-86 interleukin 1 beta Rattus norvegicus 173-191 8641730-2 1996 Incubation of cultures with interleukin-1beta (10 ng/mL) for 24 hours caused a significant increase in nitrite generation. Nitrites 103-110 interleukin 1 beta Rattus norvegicus 28-45 8641730-3 1996 The interleukin-1beta-induced nitrite production by vascular smooth muscle cells was significantly increased by adrenomedullin in a dose-dependent manner (10(-10) to 10(-6) mol/L). Nitrites 30-37 interleukin 1 beta Rattus norvegicus 4-21 8641730-5 1996 The adrenomedullin-induced nitrite production by interleukin-1beta-stimulated cells was accompanied by increased inducible nitric oxide synthase mRNA accumulation. Nitrites 27-34 interleukin 1 beta Rattus norvegicus 49-66 8641730-6 1996 In the presence of the phosphodiesterase inhibitor isobutylmethylxanthine, interleukin-1beta-induced nitrite accumulation was further increased, but the effect of adrenomedullin was not additive or synergistic. 1-Methyl-3-isobutylxanthine 51-73 interleukin 1 beta Rattus norvegicus 75-92 8641730-6 1996 In the presence of the phosphodiesterase inhibitor isobutylmethylxanthine, interleukin-1beta-induced nitrite accumulation was further increased, but the effect of adrenomedullin was not additive or synergistic. Nitrites 101-108 interleukin 1 beta Rattus norvegicus 75-92 8641730-8 1996 These results indicate that adrenomedullin augments nitric oxide synthesis in interleukin-1beta-stimulated vascular smooth muscle cells, at least partially through a cAMP-dependent pathway. Nitric Oxide 52-64 interleukin 1 beta Rattus norvegicus 78-95 8641730-8 1996 These results indicate that adrenomedullin augments nitric oxide synthesis in interleukin-1beta-stimulated vascular smooth muscle cells, at least partially through a cAMP-dependent pathway. Cyclic AMP 166-170 interleukin 1 beta Rattus norvegicus 78-95 8658961-0 1996 A bacteria-expressed mouse interleukin-1 receptor antagonist peptide protects alginate-poly-L-lysine-alginate microencapsulated rat islets against the suppressive effect of interleukin-1 beta in vitro. alginate-polylysine-alginate 87-109 interleukin 1 beta Rattus norvegicus 173-191 8662674-5 1996 Following a 24-h exposure to IL-1beta and IFNgamma, arginine uptake increases Vmax = 167 pmol/2 X 10(5) cells/min) and a second low-affinity L-arginine transporter activity appears (Km = 1.2 mM). Arginine 52-60 interleukin 1 beta Rattus norvegicus 29-37 8626679-4 1996 Interleukin-1 beta and tumor necrosis factor-alpha, alone or in combination, stimulated both the uptake of L-arginine and the accumulation of nitrite in the culture media in a dose-dependent manner. Arginine 107-117 interleukin 1 beta Rattus norvegicus 0-50 8662674-10 1996 Thus, NO production by cardiac myocytes exposed to IL-1beta plus IFNgamma appears to be dependent on the coinduction of CAT-1, CAT-2A, and CAT-2B, while insulin independently augments L-arginine transport through CAT- 1. Arginine 184-194 interleukin 1 beta Rattus norvegicus 51-59 8761989-2 1996 In order to determine whether interleukin-1 beta (IL-1 beta)-induced Fos protein expression in the paraventricular hypothalamic nucleus (PVN) can be reduced or eliminated by a c-fos antisense oligodeoxynucleotide, rats were injected with c-fos antisense and Fos expression was examined immunocytochemically. Oligodeoxyribonucleotides 192-212 interleukin 1 beta Rattus norvegicus 30-48 8626679-4 1996 Interleukin-1 beta and tumor necrosis factor-alpha, alone or in combination, stimulated both the uptake of L-arginine and the accumulation of nitrite in the culture media in a dose-dependent manner. Nitrites 142-149 interleukin 1 beta Rattus norvegicus 0-50 8761989-2 1996 In order to determine whether interleukin-1 beta (IL-1 beta)-induced Fos protein expression in the paraventricular hypothalamic nucleus (PVN) can be reduced or eliminated by a c-fos antisense oligodeoxynucleotide, rats were injected with c-fos antisense and Fos expression was examined immunocytochemically. Oligodeoxyribonucleotides 192-212 interleukin 1 beta Rattus norvegicus 50-59 8761989-3 1996 Our results indicate that c-fos antisense oligodeoxynucleotide treatment decreases the density of Fos immuno-labeled nuclei in the PVN following IL-1 beta administration. Oligodeoxyribonucleotides 42-62 interleukin 1 beta Rattus norvegicus 145-154 8625529-7 1996 In contrast, long-term incubation of alveolar macrophages with high-dose dexamethasone leads to decreased IL-1 beta and nitric oxide secretion upon subsequent stimulation. Dexamethasone 73-86 interleukin 1 beta Rattus norvegicus 106-115 8928897-1 1996 We previously reported that interleukin-1 beta (IL-1) alone stimulated nitric oxide (NO) production by neonatal rat cardiac myocytes (CM) in culture. Nitric Oxide 71-83 interleukin 1 beta Rattus norvegicus 28-46 8625529-3 1996 In the present study we have investigated both dose and timing effects of exposure of alveolar macrophages with dexamethasone on lipopolysaccharide (LPS)-induced IL-1 beta and nitric oxide secretion. Dexamethasone 112-125 interleukin 1 beta Rattus norvegicus 162-171 8612490-5 1996 Exposure to IL-1 beta (1 pM-1 nM) or TNF alpha (100 pM) for 2-4 h resulted in a significant decline in TSH release, which was almost 50% (P < 0.05) for 1 nM IL-1 beta and 24% (P < 0.05) for 100 pM TNF alpha. Thyrotropin 103-106 interleukin 1 beta Rattus norvegicus 12-21 8625529-6 1996 It was shown that both short-term incubation of alveolar macrophages with high doses of dexamethasone and long-term incubation with low doses of dexamethasone lead to enhanced nitric oxide and enhanced IL-1 beta secretion upon subsequent stimulation of the cells with LPS. Dexamethasone 88-101 interleukin 1 beta Rattus norvegicus 202-211 8625529-6 1996 It was shown that both short-term incubation of alveolar macrophages with high doses of dexamethasone and long-term incubation with low doses of dexamethasone lead to enhanced nitric oxide and enhanced IL-1 beta secretion upon subsequent stimulation of the cells with LPS. Dexamethasone 145-158 interleukin 1 beta Rattus norvegicus 202-211 8726665-7 1996 Conversely, in brain minces rIL-1 beta (but not hIL-1 beta or hIL-6) is a PGE2 activator. Dinoprostone 74-78 interleukin 1 beta Rattus norvegicus 28-38 8612490-5 1996 Exposure to IL-1 beta (1 pM-1 nM) or TNF alpha (100 pM) for 2-4 h resulted in a significant decline in TSH release, which was almost 50% (P < 0.05) for 1 nM IL-1 beta and 24% (P < 0.05) for 100 pM TNF alpha. Thyrotropin 103-106 interleukin 1 beta Rattus norvegicus 160-169 8612490-7 1996 When the effects of IL-1 beta (1 pM-1 nM) and TNF alpha (100 pM) on TRH-induced TSH release were measured in short term experiments, the inhibitory effects had disappeared. Thyrotropin 80-83 interleukin 1 beta Rattus norvegicus 20-29 8612490-11 1996 When IL-1 beta (100 pM) was present during 3 days of culture, TSH release was reduced to 88 +/- 2% of the control value (P < 0.05). Thyrotropin 62-65 interleukin 1 beta Rattus norvegicus 5-14 8647111-7 1996 Northern blot analysis using rat EC iNOS cDNA as a probe revealed that cycloheximide treatment led to a marked accumulation of iNOS mRNA in the presence and absence of interleukin-1 beta. Cycloheximide 71-84 interleukin 1 beta Rattus norvegicus 168-186 8612490-13 1996 We conclude that 1) IL-1 beta decreases TSH release by a direct action on the pituitary; 2) this effect is not due to elevated thyroid hormone uptake or increase T3 nuclear occupancy; 3) IL-1 beta does not affect TRH-induced TSH release or the release of other anterior pituitary hormones; and 4) TNF alpha affects basal and TRH-induced TSH release in the same way as IL-1 beta. Thyrotropin 40-43 interleukin 1 beta Rattus norvegicus 20-29 8773477-3 1996 Following exposure to either HAG or IL-1 beta, increased steady-state MnSOD mRNA levels were observed and an additive effect was seen following co-treatment with HAG and IL-1 beta. GSHNA 29-32 interleukin 1 beta Rattus norvegicus 170-179 8635696-4 1996 Both IL-1 beta (0.05--1 nM) and TNF-alpha (0.1--1 nM) increased, dose-dependently, the Ba2+ current carried in VSM Ca channels, whereas heat-denatured IL-1 beta was without significant effect on the channel. N-methyl-valyl-amiclenomycin 87-91 interleukin 1 beta Rattus norvegicus 5-14 8635696-9 1996 These data demonstrate that IL-1 beta, TNF-alpha, and LPS have immediate effects on VSM cells via an interaction with the voltage-sensitive Ca channel, and these effects may he regulated by intracellular cGMP. Cyclic GMP 204-208 interleukin 1 beta Rattus norvegicus 28-37 8664982-7 1996 Dopamine increased basal IL-6 release and potentiated IL-6 release stimulated by ACTH, LPS or IL-1 beta. Dopamine 0-8 interleukin 1 beta Rattus norvegicus 94-103 8664982-8 1996 Dopamine inhibited basal and secretagogue-stimulated (LPS and IL-1 beta) TNF release. Dopamine 0-8 interleukin 1 beta Rattus norvegicus 62-71 8773477-6 1996 Our data on the induction of the MnSOD gene by immune complexes and IL-1 beta could indicate an important role for MnSOD in the cellular defense against ROS toxicity in glomerular inflammation. Reactive Oxygen Species 153-156 interleukin 1 beta Rattus norvegicus 68-77 8621794-2 1996 To evaluate if such synergy occurs, we evaluated the effect if IL-1 beta and NO on the formation of prostaglandin (PG)E2 and cyclooxygenase (COX) expression. Dinoprostone 100-120 interleukin 1 beta Rattus norvegicus 63-72 8621794-4 1996 However, these compounds amplified IL-1 beta-induced PGE2 production. Dinoprostone 53-57 interleukin 1 beta Rattus norvegicus 35-44 8621794-5 1996 Similarly, sodium nitroprusside and S-nitroso-N-acetylpenicillamine by themselves did not induce mRNA and protein for COX-2, the inducible isoform of COX; however, they both potentiated IL-1 beta-induced mRNA and protein expression of COX-2. Nitroprusside 11-31 interleukin 1 beta Rattus norvegicus 186-195 8621794-5 1996 Similarly, sodium nitroprusside and S-nitroso-N-acetylpenicillamine by themselves did not induce mRNA and protein for COX-2, the inducible isoform of COX; however, they both potentiated IL-1 beta-induced mRNA and protein expression of COX-2. S-Nitroso-N-Acetylpenicillamine 36-67 interleukin 1 beta Rattus norvegicus 186-195 8817528-7 1996 Moreover, morphine potentiated the IL-6 response induced by IL-1 beta (400 ng, i.p. Morphine 10-18 interleukin 1 beta Rattus norvegicus 60-69 8741165-9 1996 injection of sodium salicylate 15 min prior to interleukin-1 beta administration inhibited the hyperalgesic effect of interleukin-1 beta, but not the analgesic effect. Sodium Salicylate 13-30 interleukin 1 beta Rattus norvegicus 118-136 8626526-0 1996 Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F. Ceramides 27-35 interleukin 1 beta Rattus norvegicus 0-18 8626526-0 1996 Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F. Diglycerides 40-54 interleukin 1 beta Rattus norvegicus 0-18 8626526-3 1996 It was found that IL-1beta induced a transient increase (2-5 min) in ceramide and diacylglycerol, which was not paralleled by an increase in ceramide 1-phosphate and phosphatidic acid. Ceramides 69-77 interleukin 1 beta Rattus norvegicus 18-26 8626526-3 1996 It was found that IL-1beta induced a transient increase (2-5 min) in ceramide and diacylglycerol, which was not paralleled by an increase in ceramide 1-phosphate and phosphatidic acid. Diglycerides 82-96 interleukin 1 beta Rattus norvegicus 18-26 8626526-8 1996 Transcription factor binding to the ATF/cAMP-responsive element consensus sequence was increased 4-5-fold by acetylsphingosine, PMA, or IL-1beta, whereas binding to the CCAAT/enhancer-binding protein and AP-1 elements was found to be only slightly stimulated by these three agents. Cyclic AMP 40-44 interleukin 1 beta Rattus norvegicus 136-144 8626526-11 1996 It is concluded that IL-1beta-stimulated formation of ceramide and diacylglycerol may contribute to JNK1 and ATF2 transcription factor activation, which may be a necessary (but not sufficient) step in beta-cell nitric-oxide synthase induction. Ceramides 54-62 interleukin 1 beta Rattus norvegicus 21-29 8626526-11 1996 It is concluded that IL-1beta-stimulated formation of ceramide and diacylglycerol may contribute to JNK1 and ATF2 transcription factor activation, which may be a necessary (but not sufficient) step in beta-cell nitric-oxide synthase induction. Diglycerides 67-81 interleukin 1 beta Rattus norvegicus 21-29 8741165-11 1996 Furthermore, the hyperalgesic effect of interleukin-1 beta may be mediated by prostaglandins. Prostaglandins 78-92 interleukin 1 beta Rattus norvegicus 40-58 8666334-0 1996 Interleukin 1 beta markedly stimulates nitric oxide formation in the absence of other cytokines or lipopolysaccharide in primary cultured rat hepatocytes but not in Kupffer cells. Nitric Oxide 39-51 interleukin 1 beta Rattus norvegicus 0-18 8732506-2 1996 Incubation of cardiac myocytes for 24 h with interleukin-1 beta (IL-1 beta) caused a significant increase in the production of nitrite, a stable metabolite of nitric oxide. Nitrites 127-134 interleukin 1 beta Rattus norvegicus 45-63 8732506-2 1996 Incubation of cardiac myocytes for 24 h with interleukin-1 beta (IL-1 beta) caused a significant increase in the production of nitrite, a stable metabolite of nitric oxide. Nitrites 127-134 interleukin 1 beta Rattus norvegicus 65-74 8732506-2 1996 Incubation of cardiac myocytes for 24 h with interleukin-1 beta (IL-1 beta) caused a significant increase in the production of nitrite, a stable metabolite of nitric oxide. Nitric Oxide 159-171 interleukin 1 beta Rattus norvegicus 45-63 8732506-2 1996 Incubation of cardiac myocytes for 24 h with interleukin-1 beta (IL-1 beta) caused a significant increase in the production of nitrite, a stable metabolite of nitric oxide. Nitric Oxide 159-171 interleukin 1 beta Rattus norvegicus 65-74 8732506-3 1996 Dibutyl cAMP (db-cAMP) significantly augmented nitrite production by IL-1 beta-stimulated, but not by unstimulated cells, in a dose-dependent manner. Cyclic AMP 8-12 interleukin 1 beta Rattus norvegicus 69-78 8732506-3 1996 Dibutyl cAMP (db-cAMP) significantly augmented nitrite production by IL-1 beta-stimulated, but not by unstimulated cells, in a dose-dependent manner. db-cAMP 14-21 interleukin 1 beta Rattus norvegicus 69-78 8732506-3 1996 Dibutyl cAMP (db-cAMP) significantly augmented nitrite production by IL-1 beta-stimulated, but not by unstimulated cells, in a dose-dependent manner. Nitrites 47-54 interleukin 1 beta Rattus norvegicus 69-78 8732506-7 1996 The synergistic effect of cAMP on IL-1 beta-induced nitrite accumulation was mimicked by cAMP-generating agonists forskolin and isoproterenol. Cyclic AMP 26-30 interleukin 1 beta Rattus norvegicus 34-43 8732506-7 1996 The synergistic effect of cAMP on IL-1 beta-induced nitrite accumulation was mimicked by cAMP-generating agonists forskolin and isoproterenol. Nitrites 52-59 interleukin 1 beta Rattus norvegicus 34-43 8732506-7 1996 The synergistic effect of cAMP on IL-1 beta-induced nitrite accumulation was mimicked by cAMP-generating agonists forskolin and isoproterenol. Cyclic AMP 89-93 interleukin 1 beta Rattus norvegicus 34-43 8732506-7 1996 The synergistic effect of cAMP on IL-1 beta-induced nitrite accumulation was mimicked by cAMP-generating agonists forskolin and isoproterenol. Colforsin 114-123 interleukin 1 beta Rattus norvegicus 34-43 8732506-7 1996 The synergistic effect of cAMP on IL-1 beta-induced nitrite accumulation was mimicked by cAMP-generating agonists forskolin and isoproterenol. Isoproterenol 128-141 interleukin 1 beta Rattus norvegicus 34-43 8731433-0 1996 Induction of interleukin-1 beta mRNA in the hypothalamus following subcutaneous injections of formalin into the rat hind paws. Formaldehyde 94-102 interleukin 1 beta Rattus norvegicus 13-31 8758268-10 1996 The TNF alpha, IL-1 beta and MIP-1 alpha mRNA levels decreased markedly when dexamethasone or ibuprofen given at 1 hour before LPS injection. Dexamethasone 77-90 interleukin 1 beta Rattus norvegicus 15-24 8758268-10 1996 The TNF alpha, IL-1 beta and MIP-1 alpha mRNA levels decreased markedly when dexamethasone or ibuprofen given at 1 hour before LPS injection. Ibuprofen 94-103 interleukin 1 beta Rattus norvegicus 15-24 8603098-0 1996 Regulation of energy metabolism by interleukin-1beta, but not by interleukin-6, is mediated by nitric oxide in primary cultured rat hepatocytes. Nitric Oxide 95-107 interleukin 1 beta Rattus norvegicus 35-52 8603098-4 1996 Both interleukin-1beta and interleukin-6, but not tumor necrosis factor-alpha, significantly inhibited the ATP increase time- and dose-dependently. Adenosine Triphosphate 107-110 interleukin 1 beta Rattus norvegicus 5-22 8603098-5 1996 Interleukin-1beta and interleukin-6 also stimulated lactate production. Lactic Acid 52-59 interleukin 1 beta Rattus norvegicus 0-17 8603098-6 1996 During the same period, interleukin-1beta but not interleukin-6 decreased the ketone body ratio. Ketones 78-84 interleukin 1 beta Rattus norvegicus 24-41 8603098-7 1996 Furthermore, interleukin-1beta markedly stimulated nitric oxide formation in hepatocytes, and this increase was blocked by NG-monomethyl-L-arginine (a nitric oxide synthase inhibitor) and by interleukin-1 receptor antagonist. Nitric Oxide 51-63 interleukin 1 beta Rattus norvegicus 13-30 8603098-7 1996 Furthermore, interleukin-1beta markedly stimulated nitric oxide formation in hepatocytes, and this increase was blocked by NG-monomethyl-L-arginine (a nitric oxide synthase inhibitor) and by interleukin-1 receptor antagonist. omega-N-Methylarginine 123-147 interleukin 1 beta Rattus norvegicus 13-30 8603098-8 1996 NG-monomethyl-L-arginine reversed inhibition of the ATP increase, decrease in the ketone body ratio, and increase in lactate production, which were induced by interleukin-1beta. omega-N-Methylarginine 0-24 interleukin 1 beta Rattus norvegicus 159-176 8731433-1 1996 The induction of interleukin-1 beta (IL-1 beta) mRNA in the rat brain following subcutaneous injection of formalin into the hind paws was investigated by in situ hydridization. Formaldehyde 106-114 interleukin 1 beta Rattus norvegicus 17-35 8603098-8 1996 NG-monomethyl-L-arginine reversed inhibition of the ATP increase, decrease in the ketone body ratio, and increase in lactate production, which were induced by interleukin-1beta. Adenosine Triphosphate 52-55 interleukin 1 beta Rattus norvegicus 159-176 8603098-8 1996 NG-monomethyl-L-arginine reversed inhibition of the ATP increase, decrease in the ketone body ratio, and increase in lactate production, which were induced by interleukin-1beta. Ketones 82-88 interleukin 1 beta Rattus norvegicus 159-176 8603098-8 1996 NG-monomethyl-L-arginine reversed inhibition of the ATP increase, decrease in the ketone body ratio, and increase in lactate production, which were induced by interleukin-1beta. Lactic Acid 117-124 interleukin 1 beta Rattus norvegicus 159-176 8603098-11 1996 Specifically, interleukin-1beta inhibits ATP synthesis by causing the mitochondrial dysfunction, a process which may be mediated by nitric oxide. Adenosine Triphosphate 41-44 interleukin 1 beta Rattus norvegicus 14-31 8603098-11 1996 Specifically, interleukin-1beta inhibits ATP synthesis by causing the mitochondrial dysfunction, a process which may be mediated by nitric oxide. Nitric Oxide 132-144 interleukin 1 beta Rattus norvegicus 14-31 8901013-2 1996 Interleukin-1 beta (0.1 ng/ml) potentiation of substance P-like immunoreactivity release was abrogated by co-perfusion with interleukin-1 receptor antagonist (10-100 ng/ml) or with indomethacin (1 microM). Indomethacin 181-193 interleukin 1 beta Rattus norvegicus 0-18 8731433-1 1996 The induction of interleukin-1 beta (IL-1 beta) mRNA in the rat brain following subcutaneous injection of formalin into the hind paws was investigated by in situ hydridization. Formaldehyde 106-114 interleukin 1 beta Rattus norvegicus 37-46 8731433-2 1996 IL-1 beta mRNA was markedly induced in the hypothalamus after the injection of formalin into both hind paws. Formaldehyde 79-87 interleukin 1 beta Rattus norvegicus 0-9 8731433-4 1996 The type of cells expressing IL-1 beta mRNA was likely glia because their nuclei were densely stained by Cresyl violet and were relatively small. cresyl violet 105-118 interleukin 1 beta Rattus norvegicus 29-38 8731433-5 1996 The present results suggest that IL-1 beta mRNA is induced in the glial cells of the hypothalamus by persistent pain which is caused by formalin injection. Formaldehyde 136-144 interleukin 1 beta Rattus norvegicus 33-42 8833038-2 1996 CS treatment reduced the basal mRNA levels of IL-1 alpha and IL-1 beta, but elevated the mRNA levels of IL-6 in the hypothalamus and hippocampus as shown by RT-PCR. Corticosterone 0-2 interleukin 1 beta Rattus norvegicus 61-70 8814911-0 1996 Chronic exposure to morphine attenuates expression of interleukin-1 beta in the rat hippocampus. Morphine 20-28 interleukin 1 beta Rattus norvegicus 54-72 8814911-2 1996 Alteration of IL-1 beta expression by exogenous factors, such as morphine, may affect the neuro-endocrine-immune axis. Morphine 65-73 interleukin 1 beta Rattus norvegicus 14-23 8814911-4 1996 The results showed pronounced attenuation of IL-1 beta immuno-reactivity in the dentate gyrus and the CA1-CA3 fields of the hippocampus in morphine-implanted rats compared to placebo controls. Morphine 139-147 interleukin 1 beta Rattus norvegicus 45-54 8814911-6 1996 Attenuation of IL-1 beta expression in the hippocampus by chronic exposure to morphine may be one of the mechanisms underlying the neuro-endocrine-immune modulatory effects of opiate addiction. Morphine 78-86 interleukin 1 beta Rattus norvegicus 15-24 8814911-6 1996 Attenuation of IL-1 beta expression in the hippocampus by chronic exposure to morphine may be one of the mechanisms underlying the neuro-endocrine-immune modulatory effects of opiate addiction. Opiate Alkaloids 176-182 interleukin 1 beta Rattus norvegicus 15-24 8780220-6 1996 IL-1 beta ra (200 micrograms) reversed the inhibition of gastric emptying by 34.8% (P < 0.05) in the early (30 min) postoperative period and by 32.3% (P < 0.05) in the late (120 min) postoperative period. Radium 10-12 interleukin 1 beta Rattus norvegicus 0-9 8780229-5 1996 Pretreatment of rats with the glucocorticoid receptor antagonist RU-486 prevented the IL-1 beta-induced decrease in plasma and liver IGF-I concentration and the reduction in hepatic IGF-I mRNA expression. Mifepristone 65-71 interleukin 1 beta Rattus norvegicus 86-95 8833038-7 1996 These results suggest that altered and clamped hypothalamic IL-1 alpha, IL-1 beta and IL-6 mRNA levels may be involved in the antipyretic effects of a pretreatment with high doses of CS and that these CS effects are rapidly reversible. Corticosterone 183-185 interleukin 1 beta Rattus norvegicus 72-81 8830053-5 1996 S-EIU suppressed the release of nitrite and lactate dehydrogenase from rat vascular smooth muscle cells treated with interleukin-1 beta and forskolin more potently than L-NMA or L-NNA. Nitrites 32-39 interleukin 1 beta Rattus norvegicus 117-135 9273361-11 1996 rIL-1beta-pretreated MCs induced a rapid increase in intracellular Ca2+ in PMNs; actinomycin D blocked this effect and was also able to prevent adhesion of neutrophils to activated MC monolayers. Dactinomycin 81-94 interleukin 1 beta Rattus norvegicus 0-9 9273361-11 1996 rIL-1beta-pretreated MCs induced a rapid increase in intracellular Ca2+ in PMNs; actinomycin D blocked this effect and was also able to prevent adhesion of neutrophils to activated MC monolayers. Methylcholanthrene 21-23 interleukin 1 beta Rattus norvegicus 0-9 8677009-6 1996 Both routes of administration of IL-1 beta resulted in significant and comparable activation of the HPA axis, as assessed by analysis of plasma conrticosterone. conrticosterone 144-159 interleukin 1 beta Rattus norvegicus 33-42 8904084-6 1996 Dipyridamole up-regulated the effect of both 8-bromo-cGMP and db-cAMP on the interleukin-1beta-induced nitrite production. Nitrites 103-110 interleukin 1 beta Rattus norvegicus 77-94 8945723-3 1996 The number of IL-1 beta-induced c-fos-positive cells in the PVN and SON was significantly lower in rats pretreated with indomethacin than in vehicle-treated rats. Indomethacin 120-132 interleukin 1 beta Rattus norvegicus 14-23 8945723-6 1996 The induction of c-fos immunoreactivity by central administration of IL-1 beta was blocked by indomethacin (500 micrograms/rat), except in the CeA. Indomethacin 94-106 interleukin 1 beta Rattus norvegicus 69-78 9011616-8 1996 Plasma concentration of corticosterone increased significantly after injection of IL-1 beta (10 micrograms kg-1). Corticosterone 24-38 interleukin 1 beta Rattus norvegicus 82-91 9011616-13 1996 After bilateral adrenalectomy, the IL-1 beta (10 micrograms kg-1)-induced pressor effect was reduced; it was restored by treatment with DEX (0.5 mg kg-1). Dexamethasone 136-139 interleukin 1 beta Rattus norvegicus 35-44 9011616-16 1996 IL-1 beta (10 micrograms kg-1)-induced increases in plasma noradrenaline (NA) were suppressed in intact rats pretreated with DEX (0.5 mg kg-1). Norepinephrine 59-72 interleukin 1 beta Rattus norvegicus 0-9 9011616-16 1996 IL-1 beta (10 micrograms kg-1)-induced increases in plasma noradrenaline (NA) were suppressed in intact rats pretreated with DEX (0.5 mg kg-1). Dexamethasone 125-128 interleukin 1 beta Rattus norvegicus 0-9 8904084-0 1996 Dipyridamole enhances interleukin-1beta-stimulated nitric oxide production by cultured rat vascular smooth muscle cells. Dipyridamole 0-12 interleukin 1 beta Rattus norvegicus 22-39 8904084-0 1996 Dipyridamole enhances interleukin-1beta-stimulated nitric oxide production by cultured rat vascular smooth muscle cells. Nitric Oxide 51-63 interleukin 1 beta Rattus norvegicus 22-39 8904084-7 1996 Dipyridamole increased the intracellular cAMP content in the presence of interleukin-1beta (10 ng/ml), but did not affect the intracellular cGMP content. Dipyridamole 0-12 interleukin 1 beta Rattus norvegicus 73-90 8904084-1 1996 We examined whether dipyridamole affected interleukin-1beta-stimulated nitric oxide (NO) production by cultured rat vascular smooth muscle cells. Dipyridamole 20-32 interleukin 1 beta Rattus norvegicus 42-59 8904084-7 1996 Dipyridamole increased the intracellular cAMP content in the presence of interleukin-1beta (10 ng/ml), but did not affect the intracellular cGMP content. Cyclic AMP 41-45 interleukin 1 beta Rattus norvegicus 73-90 8904084-1 1996 We examined whether dipyridamole affected interleukin-1beta-stimulated nitric oxide (NO) production by cultured rat vascular smooth muscle cells. Nitric Oxide 71-83 interleukin 1 beta Rattus norvegicus 42-59 8904084-2 1996 Interleukin-1beta stimulated the production of nitrite and nitrate, stable metabolites of NO, in a dose- and time-dependent manner in vascular smooth muscle cells. Nitrites 47-54 interleukin 1 beta Rattus norvegicus 0-17 8848910-3 1996 We studied whether high-dose fentanyl may influence the IL-1 beta-induced alterations in plasma ACTH and corticosterone in rats. Fentanyl 29-37 interleukin 1 beta Rattus norvegicus 56-65 8848910-3 1996 We studied whether high-dose fentanyl may influence the IL-1 beta-induced alterations in plasma ACTH and corticosterone in rats. Corticosterone 105-119 interleukin 1 beta Rattus norvegicus 56-65 8848910-9 1996 Fentanyl moderately increased the basal blood pressure and heart rate, but it moderately attenuated the IL-1 beta-induced elevations of blood pressure and heart rate. Fentanyl 0-8 interleukin 1 beta Rattus norvegicus 104-113 8848910-10 1996 IL-1 beta moderately decreased PCO2 in awake animals. pco2 31-35 interleukin 1 beta Rattus norvegicus 0-9 8904084-2 1996 Interleukin-1beta stimulated the production of nitrite and nitrate, stable metabolites of NO, in a dose- and time-dependent manner in vascular smooth muscle cells. Nitrates 59-66 interleukin 1 beta Rattus norvegicus 0-17 8904084-3 1996 Dipyridamole (1-100 mu M) enhanced interleukin-1beta-induced nitrite production in a dose- and time-dependent manner. Dipyridamole 0-12 interleukin 1 beta Rattus norvegicus 35-52 8904084-3 1996 Dipyridamole (1-100 mu M) enhanced interleukin-1beta-induced nitrite production in a dose- and time-dependent manner. Nitrites 61-68 interleukin 1 beta Rattus norvegicus 35-52 8904084-5 1996 Both 8-bromo-guanosine 3",5"-cyclic monophosphate (8-bromo-cGMP) and dibutyryl adenosine 3",5"-cyclic monophosphate (db-cAMP) enhanced the nitrite production in the presence of interleukin-1beta. 8-bromocyclic GMP 5-49 interleukin 1 beta Rattus norvegicus 177-194 8904084-5 1996 Both 8-bromo-guanosine 3",5"-cyclic monophosphate (8-bromo-cGMP) and dibutyryl adenosine 3",5"-cyclic monophosphate (db-cAMP) enhanced the nitrite production in the presence of interleukin-1beta. 8-bromocyclic GMP 51-63 interleukin 1 beta Rattus norvegicus 177-194 8904084-5 1996 Both 8-bromo-guanosine 3",5"-cyclic monophosphate (8-bromo-cGMP) and dibutyryl adenosine 3",5"-cyclic monophosphate (db-cAMP) enhanced the nitrite production in the presence of interleukin-1beta. Bucladesine 69-115 interleukin 1 beta Rattus norvegicus 177-194 8904084-5 1996 Both 8-bromo-guanosine 3",5"-cyclic monophosphate (8-bromo-cGMP) and dibutyryl adenosine 3",5"-cyclic monophosphate (db-cAMP) enhanced the nitrite production in the presence of interleukin-1beta. Nitrites 139-146 interleukin 1 beta Rattus norvegicus 177-194 8904084-6 1996 Dipyridamole up-regulated the effect of both 8-bromo-cGMP and db-cAMP on the interleukin-1beta-induced nitrite production. Dipyridamole 0-12 interleukin 1 beta Rattus norvegicus 77-94 8904084-6 1996 Dipyridamole up-regulated the effect of both 8-bromo-cGMP and db-cAMP on the interleukin-1beta-induced nitrite production. 8-bromocyclic GMP 45-57 interleukin 1 beta Rattus norvegicus 77-94 8904084-6 1996 Dipyridamole up-regulated the effect of both 8-bromo-cGMP and db-cAMP on the interleukin-1beta-induced nitrite production. Bucladesine 62-69 interleukin 1 beta Rattus norvegicus 77-94 8904084-9 1996 Furthermore, Rolipram and 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (Ro-20-1724), cAMP-specific phosphodiesterase type IV inhibitors, augmented the interleukin-1beta-induced nitrite production. 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone 26-72 interleukin 1 beta Rattus norvegicus 153-170 8904084-9 1996 Furthermore, Rolipram and 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (Ro-20-1724), cAMP-specific phosphodiesterase type IV inhibitors, augmented the interleukin-1beta-induced nitrite production. 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone 74-84 interleukin 1 beta Rattus norvegicus 153-170 8904084-9 1996 Furthermore, Rolipram and 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (Ro-20-1724), cAMP-specific phosphodiesterase type IV inhibitors, augmented the interleukin-1beta-induced nitrite production. Nitrites 179-186 interleukin 1 beta Rattus norvegicus 153-170 8904084-10 1996 We concluded that dipyridamole enhanced the interleukin-1beta-induced NO production via an increase in intracellular cAMP content in cultured rat vascular smooth muscle cells. Dipyridamole 18-30 interleukin 1 beta Rattus norvegicus 44-61 8904084-10 1996 We concluded that dipyridamole enhanced the interleukin-1beta-induced NO production via an increase in intracellular cAMP content in cultured rat vascular smooth muscle cells. Cyclic AMP 117-121 interleukin 1 beta Rattus norvegicus 44-61 8654401-3 1996 PLA2 expression in TBSMC cultures was markedly increased by tumour-necrosis factor (TNF) alpha (130-fold) and interleukin-1beta (IL-1beta) (7.4-fold). tbsmc 19-24 interleukin 1 beta Rattus norvegicus 110-127 8779882-2 1996 Either intravenous or intracerebroventricular administration of IL-1 beta elicited increases in AP, HR, and RSNA accompanied by a rise in body temperature. rsna 108-112 interleukin 1 beta Rattus norvegicus 64-73 8779882-3 1996 The maximum changes in AP, HR, and RSNA occurred 10-15 min after intravenous injection of IL-1 beta (100 ng) and 20-25 min after intracerebroventricular injection (5 ng). rsna 35-39 interleukin 1 beta Rattus norvegicus 90-99 8779882-6 1996 Plasma norepinephrine and adrenocorticotropic hormone concentrations were increased after IL-1 beta injection. Norepinephrine 7-21 interleukin 1 beta Rattus norvegicus 90-99 8779882-7 1996 The results suggested that IL-1 beta augments cardiovascular and sympathetic outflow through the central action of prostaglandin E2 in conscious rats. Dinoprostone 115-131 interleukin 1 beta Rattus norvegicus 27-36 8788197-0 1996 Inhibition of nitric oxide: effects on interleukin-1 beta-enhanced ovulation rate, steroid hormones, and ovarian leukocyte distribution at ovulation in the rat. Nitric Oxide 14-26 interleukin 1 beta Rattus norvegicus 39-57 8788197-2 1996 Nitric oxide (NO), a potent vasodilator and the main mediator of macrophage tumoricidal and bacteriocidal activities, is known to participate in inflammatory reactions and has been shown to mediate the interleukin-1 beta (IL-1 beta)-directed tissue-remodeling events within the ovary. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 202-220 8788197-2 1996 Nitric oxide (NO), a potent vasodilator and the main mediator of macrophage tumoricidal and bacteriocidal activities, is known to participate in inflammatory reactions and has been shown to mediate the interleukin-1 beta (IL-1 beta)-directed tissue-remodeling events within the ovary. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 222-231 8788197-6 1996 The addition of L-NAME to LH+IL-1 beta (4 ng/ml)-perfused ovaries decreased ovulation rate from 15.2 +/- 2.4 to 0.8 +/- 0.8 ovulations per ovary (p < 0.001) and simultaneously decreased nitrite accumulation at 22 h from 22.8 +/- 2.2 to 1.9 +/- 0.6 nmol/ml (p < 0.001). NG-Nitroarginine Methyl Ester 16-22 interleukin 1 beta Rattus norvegicus 29-38 8630528-0 1996 Interleukin-1 beta-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine. Nitric Oxide 27-39 interleukin 1 beta Rattus norvegicus 0-18 8630528-0 1996 Interleukin-1 beta-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine. Glucose 92-101 interleukin 1 beta Rattus norvegicus 0-18 8630528-0 1996 Interleukin-1 beta-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine. 1-Methyl-3-isobutylxanthine 106-134 interleukin 1 beta Rattus norvegicus 0-18 8630528-1 1996 Interleukin-1 beta has been proposed to cause selective beta-cell destruction via the induction of nitric oxide synthesis. Nitric Oxide 99-111 interleukin 1 beta Rattus norvegicus 0-18 8630528-2 1996 The cytotoxic effect of interleukin-1 beta is modulated by the concentration of D-glucose in the medium. Glucose 80-89 interleukin 1 beta Rattus norvegicus 24-42 8630528-3 1996 The aim of this study was to investigate if D-glucose-mediated modulation of interleukin-1 beta effects on insulin release from isolated rat islets was related to modulation of nitric oxide production. Glucose 44-53 interleukin 1 beta Rattus norvegicus 77-95 8630528-3 1996 The aim of this study was to investigate if D-glucose-mediated modulation of interleukin-1 beta effects on insulin release from isolated rat islets was related to modulation of nitric oxide production. Nitric Oxide 177-189 interleukin 1 beta Rattus norvegicus 77-95 8630528-4 1996 Further, we wished to investigate the effects of agents increasing the intracellular concentration of cAMP on interleukin-1 beta-induced nitrite production. Cyclic AMP 102-106 interleukin 1 beta Rattus norvegicus 110-128 8630528-4 1996 Further, we wished to investigate the effects of agents increasing the intracellular concentration of cAMP on interleukin-1 beta-induced nitrite production. Nitrites 137-144 interleukin 1 beta Rattus norvegicus 110-128 8630528-5 1996 We demonstrated that D-glucose potentiated interleukin-1 beta-induced nitrite production in rat islets without affecting the mRNA level of the inducible nitric oxide synthase. Glucose 21-30 interleukin 1 beta Rattus norvegicus 43-61 8630528-5 1996 We demonstrated that D-glucose potentiated interleukin-1 beta-induced nitrite production in rat islets without affecting the mRNA level of the inducible nitric oxide synthase. Nitrites 70-77 interleukin 1 beta Rattus norvegicus 43-61 8630528-6 1996 This effect was dissociated from interleukin-1 beta action on insulin release, since a relative protection against interleukin-1 beta effects on acute insulin release was found at high (28 mmol/l) concentrations of D-glucose, and blocking nitrite production by the L-arginine analog aminoguanidine, which selectively inhibits the cytokine-inducible nitric oxide synthase, did not result in protection against the inhibitory action of interleukin-1 beta. Glucose 215-224 interleukin 1 beta Rattus norvegicus 115-133 8630528-6 1996 This effect was dissociated from interleukin-1 beta action on insulin release, since a relative protection against interleukin-1 beta effects on acute insulin release was found at high (28 mmol/l) concentrations of D-glucose, and blocking nitrite production by the L-arginine analog aminoguanidine, which selectively inhibits the cytokine-inducible nitric oxide synthase, did not result in protection against the inhibitory action of interleukin-1 beta. Glucose 215-224 interleukin 1 beta Rattus norvegicus 115-133 8630528-6 1996 This effect was dissociated from interleukin-1 beta action on insulin release, since a relative protection against interleukin-1 beta effects on acute insulin release was found at high (28 mmol/l) concentrations of D-glucose, and blocking nitrite production by the L-arginine analog aminoguanidine, which selectively inhibits the cytokine-inducible nitric oxide synthase, did not result in protection against the inhibitory action of interleukin-1 beta. Nitrites 239-246 interleukin 1 beta Rattus norvegicus 115-133 8630528-6 1996 This effect was dissociated from interleukin-1 beta action on insulin release, since a relative protection against interleukin-1 beta effects on acute insulin release was found at high (28 mmol/l) concentrations of D-glucose, and blocking nitrite production by the L-arginine analog aminoguanidine, which selectively inhibits the cytokine-inducible nitric oxide synthase, did not result in protection against the inhibitory action of interleukin-1 beta. Nitrites 239-246 interleukin 1 beta Rattus norvegicus 115-133 8630528-6 1996 This effect was dissociated from interleukin-1 beta action on insulin release, since a relative protection against interleukin-1 beta effects on acute insulin release was found at high (28 mmol/l) concentrations of D-glucose, and blocking nitrite production by the L-arginine analog aminoguanidine, which selectively inhibits the cytokine-inducible nitric oxide synthase, did not result in protection against the inhibitory action of interleukin-1 beta. Arginine 265-275 interleukin 1 beta Rattus norvegicus 115-133 8630528-6 1996 This effect was dissociated from interleukin-1 beta action on insulin release, since a relative protection against interleukin-1 beta effects on acute insulin release was found at high (28 mmol/l) concentrations of D-glucose, and blocking nitrite production by the L-arginine analog aminoguanidine, which selectively inhibits the cytokine-inducible nitric oxide synthase, did not result in protection against the inhibitory action of interleukin-1 beta. Arginine 265-275 interleukin 1 beta Rattus norvegicus 115-133 8654401-3 1996 PLA2 expression in TBSMC cultures was markedly increased by tumour-necrosis factor (TNF) alpha (130-fold) and interleukin-1beta (IL-1beta) (7.4-fold). tbsmc 19-24 interleukin 1 beta Rattus norvegicus 129-137 8549863-2 1996 Nitric oxide has been implicated as one possible mediator of interleukin-1 beta (IL-1)-induced inhibition of insulin secretion and islet cell damage. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 61-79 8630528-6 1996 This effect was dissociated from interleukin-1 beta action on insulin release, since a relative protection against interleukin-1 beta effects on acute insulin release was found at high (28 mmol/l) concentrations of D-glucose, and blocking nitrite production by the L-arginine analog aminoguanidine, which selectively inhibits the cytokine-inducible nitric oxide synthase, did not result in protection against the inhibitory action of interleukin-1 beta. pimagedine 283-297 interleukin 1 beta Rattus norvegicus 115-133 8630528-6 1996 This effect was dissociated from interleukin-1 beta action on insulin release, since a relative protection against interleukin-1 beta effects on acute insulin release was found at high (28 mmol/l) concentrations of D-glucose, and blocking nitrite production by the L-arginine analog aminoguanidine, which selectively inhibits the cytokine-inducible nitric oxide synthase, did not result in protection against the inhibitory action of interleukin-1 beta. pimagedine 283-297 interleukin 1 beta Rattus norvegicus 115-133 8630528-8 1996 The phosphodiesterase inhibitor 3-isobutyl-1-methyl xanthine reduced interleukin-1 beta-induced nitrite production at 3.3 mmol/l D-glucose, an effect that could be reproduced by the cAMP analog dibutyryl cAMP. 1-Methyl-3-isobutylxanthine 32-60 interleukin 1 beta Rattus norvegicus 69-87 8630528-8 1996 The phosphodiesterase inhibitor 3-isobutyl-1-methyl xanthine reduced interleukin-1 beta-induced nitrite production at 3.3 mmol/l D-glucose, an effect that could be reproduced by the cAMP analog dibutyryl cAMP. Nitrites 96-103 interleukin 1 beta Rattus norvegicus 69-87 8630528-8 1996 The phosphodiesterase inhibitor 3-isobutyl-1-methyl xanthine reduced interleukin-1 beta-induced nitrite production at 3.3 mmol/l D-glucose, an effect that could be reproduced by the cAMP analog dibutyryl cAMP. Glucose 129-138 interleukin 1 beta Rattus norvegicus 69-87 8630528-8 1996 The phosphodiesterase inhibitor 3-isobutyl-1-methyl xanthine reduced interleukin-1 beta-induced nitrite production at 3.3 mmol/l D-glucose, an effect that could be reproduced by the cAMP analog dibutyryl cAMP. Cyclic AMP 182-186 interleukin 1 beta Rattus norvegicus 69-87 8630528-8 1996 The phosphodiesterase inhibitor 3-isobutyl-1-methyl xanthine reduced interleukin-1 beta-induced nitrite production at 3.3 mmol/l D-glucose, an effect that could be reproduced by the cAMP analog dibutyryl cAMP. Cyclic AMP 204-208 interleukin 1 beta Rattus norvegicus 69-87 8630528-9 1996 Addition of 3-isobutyl-1-methyl xanthine resulted in a threefold reduction in the mRNA level of interleukin-1 beta-induced inducible nitric oxide synthase. 1-Methyl-3-isobutylxanthine 12-40 interleukin 1 beta Rattus norvegicus 96-114 8630528-10 1996 We conclude that interleukin-1 beta-induced islet nitric oxide synthesis is augmented by D-glucose, but not by non-substrate secretagogues, and that secretagogues that elevate cAMP inhibit islet nitric oxide production. Nitric Oxide 50-62 interleukin 1 beta Rattus norvegicus 17-35 8630528-10 1996 We conclude that interleukin-1 beta-induced islet nitric oxide synthesis is augmented by D-glucose, but not by non-substrate secretagogues, and that secretagogues that elevate cAMP inhibit islet nitric oxide production. Glucose 89-98 interleukin 1 beta Rattus norvegicus 17-35 8630528-10 1996 We conclude that interleukin-1 beta-induced islet nitric oxide synthesis is augmented by D-glucose, but not by non-substrate secretagogues, and that secretagogues that elevate cAMP inhibit islet nitric oxide production. Cyclic AMP 176-180 interleukin 1 beta Rattus norvegicus 17-35 8630528-10 1996 We conclude that interleukin-1 beta-induced islet nitric oxide synthesis is augmented by D-glucose, but not by non-substrate secretagogues, and that secretagogues that elevate cAMP inhibit islet nitric oxide production. Nitric Oxide 195-207 interleukin 1 beta Rattus norvegicus 17-35 8591863-8 1996 These results suggest that production of CINC by hepatocytes could be regulated by IL-1 beta released from Kupffer cells, leading to neutrophil accumulation during liver injury, because this protein is a strong chemoattractant for neutrophils. Zinc 41-45 interleukin 1 beta Rattus norvegicus 83-92 8641570-8 1996 Incubation of these endothelial cells with recombinant rat IL-1beta showed a dose-dependent increase in interleukin-6, prostaglandin E(2), and prostacyclin secretion. Dinoprostone 119-137 interleukin 1 beta Rattus norvegicus 59-67 8641570-8 1996 Incubation of these endothelial cells with recombinant rat IL-1beta showed a dose-dependent increase in interleukin-6, prostaglandin E(2), and prostacyclin secretion. Epoprostenol 143-155 interleukin 1 beta Rattus norvegicus 59-67 8641570-9 1996 Intravenous administration of rat IL-1beta to adult rats enhanced prostaglandin E(2) immunoreactivity in endothelial cells of the brain microvasculature. Dinoprostone 66-84 interleukin 1 beta Rattus norvegicus 34-42 8774059-1 1996 Immature (3 week old) rat offspring of alcohol (E)-fed dams show a blunted ACTH response to immune signals such as interleukin-1 beta (IL-1 beta) and endotoxin (LPS). Alcohols 39-46 interleukin 1 beta Rattus norvegicus 115-133 8868260-0 1996 Corticosterone controls interleukin-1 beta expression and sickness behavior in the rat. Corticosterone 0-14 interleukin 1 beta Rattus norvegicus 24-42 8868260-7 1996 Administration of corticosterone 1 h before LPS lowered the splenic IL-1 beta mRNA content compared to LPS-treated adrenal-intact rats that did not receive corticosterone and inhibited fever and anorexia, whereas the glucocorticoid did not attenuate the endotoxin-induced suppression of locomotor activity. Corticosterone 18-32 interleukin 1 beta Rattus norvegicus 68-77 8868260-8 1996 Our data suggest that during inflammatory conditions body temperature, sickness behavior and the synthesis of IL-1 beta are controlled by corticosterone. Corticosterone 138-152 interleukin 1 beta Rattus norvegicus 110-119 8774059-1 1996 Immature (3 week old) rat offspring of alcohol (E)-fed dams show a blunted ACTH response to immune signals such as interleukin-1 beta (IL-1 beta) and endotoxin (LPS). Alcohols 39-46 interleukin 1 beta Rattus norvegicus 135-144 8579596-1 1996 We have previously demonstrated that interleukin-1 beta (IL-1 beta) rapidly induces tyrosine phosphorylation of several proteins in the renal mesangial cell. Tyrosine 84-92 interleukin 1 beta Rattus norvegicus 37-55 8579596-2 1996 Two mechanistically distinct tyrosine kinase inhibitors, genistein and herbimycin A, block the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) by IL-1 beta in rat mesangial cells. Genistein 57-66 interleukin 1 beta Rattus norvegicus 179-188 8579596-1 1996 We have previously demonstrated that interleukin-1 beta (IL-1 beta) rapidly induces tyrosine phosphorylation of several proteins in the renal mesangial cell. Tyrosine 84-92 interleukin 1 beta Rattus norvegicus 57-66 8579596-2 1996 Two mechanistically distinct tyrosine kinase inhibitors, genistein and herbimycin A, block the induction of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) by IL-1 beta in rat mesangial cells. herbimycin 71-83 interleukin 1 beta Rattus norvegicus 179-188 8576166-7 1996 In an electrophoretic mobility shift assay, dexamethasone diminished the IL-1 beta-induced formation of NF-kappa B complexes, which consisted of p65 and p50. Dexamethasone 44-57 interleukin 1 beta Rattus norvegicus 73-82 8576166-8 1996 Western blotting revealed that dexamethasone inhibited the IL-1 beta-induced translocation of p65 from the cytoplasm into the nucleus, while the nuclear level of NF-kappa B p50 remained almost unchanged. Dexamethasone 31-44 interleukin 1 beta Rattus norvegicus 59-68 8576166-1 1996 The glucocorticoid dexamethasone inhibited the production of the rat cytokine-induced neutrophil chemoattractant CINC/gro, a counterpart of human melanoma growth-stimulating activity that belongs to the interleukin-8 (IL-8) family, in the normal rat kidney epithelial cell line NRK-52E stimulated with interleukin-1 beta (IL-1 beta), lipopolysaccharide, or tumor necrosis factor alpha. Dexamethasone 19-32 interleukin 1 beta Rattus norvegicus 302-320 8769830-3 1996 In rat mesangial cells treated with an inhibitor of NF-kappa B, pyrrolidine dithiocarbamate, induction of MMP-9 by IL-1 beta was suppressed at both mRNA and protein levels. pyrrolidine dithiocarbamic acid 64-91 interleukin 1 beta Rattus norvegicus 115-124 8576166-1 1996 The glucocorticoid dexamethasone inhibited the production of the rat cytokine-induced neutrophil chemoattractant CINC/gro, a counterpart of human melanoma growth-stimulating activity that belongs to the interleukin-8 (IL-8) family, in the normal rat kidney epithelial cell line NRK-52E stimulated with interleukin-1 beta (IL-1 beta), lipopolysaccharide, or tumor necrosis factor alpha. Dexamethasone 19-32 interleukin 1 beta Rattus norvegicus 322-331 8576166-3 1996 A nuclear run-on assay revealed that dexamethasone decreased the IL-1 beta-induced transcription of the CINC/gro gene. Dexamethasone 37-50 interleukin 1 beta Rattus norvegicus 65-74 8552616-0 1996 Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin 1 beta-stimulated mesangial cells: evidence for the involvement of transcriptional and posttranscriptional regulation. Dexamethasone 24-37 interleukin 1 beta Rattus norvegicus 88-106 8552616-2 1996 We have reported that nanomolar concentrations of dexamethasone suppress IL-1 beta-induced iNOS protein expression and production of nitrite, the stable end product of NO formation, without affecting IL-1 beta-triggered increase in iNOS mRNA levels. Dexamethasone 50-63 interleukin 1 beta Rattus norvegicus 73-82 8552616-2 1996 We have reported that nanomolar concentrations of dexamethasone suppress IL-1 beta-induced iNOS protein expression and production of nitrite, the stable end product of NO formation, without affecting IL-1 beta-triggered increase in iNOS mRNA levels. Nitrites 133-140 interleukin 1 beta Rattus norvegicus 73-82 8552616-3 1996 We now have studied the mechanisms by which dexamethasone suppresses IL-1 beta-stimulated iNOS expression in mesangial cells. Dexamethasone 44-57 interleukin 1 beta Rattus norvegicus 69-78 8552616-4 1996 Surprisingly, nuclear run-on transcription experiments demonstrate that dexamethasone markedly attenuates IL-1 beta-induced iNOS gene transcription. Dexamethasone 72-85 interleukin 1 beta Rattus norvegicus 106-115 8794213-0 1996 Amplification of nitric oxide synthase expression by nitric oxide in interleukin 1beta-stimulated rat mesangial cells. nitric 17-23 interleukin 1 beta Rattus norvegicus 69-86 8794213-0 1996 Amplification of nitric oxide synthase expression by nitric oxide in interleukin 1beta-stimulated rat mesangial cells. Nitric Oxide 17-29 interleukin 1 beta Rattus norvegicus 69-86 8557638-8 1996 The farnesyl transferase inhibitor BZA-5B blocked activation of ERK1/ERK2 and induction of NOS2 by IFN gamma and IL-1 beta in myocytes. BZA 5B 35-41 interleukin 1 beta Rattus norvegicus 113-122 8557638-9 1996 IL-1 beta and IFN gamma-induced NOS2 gene expression in myocytes was also down-regulated by both protein kinase C (PKC) desensitization and by the PKC inhibitor bisindolylmaleimide, implicating PKC-linked activation of Ras or Raf in the induction of NOS2 by IL-1 beta and IFN gamma in cardiac muscle cells. bisindolylmaleimide 161-180 interleukin 1 beta Rattus norvegicus 0-9 8557638-9 1996 IL-1 beta and IFN gamma-induced NOS2 gene expression in myocytes was also down-regulated by both protein kinase C (PKC) desensitization and by the PKC inhibitor bisindolylmaleimide, implicating PKC-linked activation of Ras or Raf in the induction of NOS2 by IL-1 beta and IFN gamma in cardiac muscle cells. bisindolylmaleimide 161-180 interleukin 1 beta Rattus norvegicus 258-267 8557638-10 1996 In CMEC, the MAPK kinase inhibitor PD 98059 blocked activation of ERK1/ERK2 and down-regulated IL-1 beta-mediated NOS2 induction, whereas activation of ERK2 in the absence of cytokines by okadaic acid, an inhibitor of phosphoserine protein phosphatases, also induced NOS2 mRNA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-43 interleukin 1 beta Rattus norvegicus 95-104 8557638-10 1996 In CMEC, the MAPK kinase inhibitor PD 98059 blocked activation of ERK1/ERK2 and down-regulated IL-1 beta-mediated NOS2 induction, whereas activation of ERK2 in the absence of cytokines by okadaic acid, an inhibitor of phosphoserine protein phosphatases, also induced NOS2 mRNA. Okadaic Acid 188-200 interleukin 1 beta Rattus norvegicus 95-104 8790842-23 1996 Similarly, IL-1 beta decreased hydroxyproline content of granulation tissue seven days postoperatively and PGE2 decreased nonsignificantly the amounts of hydroxyproline but the steady-state levels of pro alpha 1(I) and pro alpha 1(III) collagen chain mRNAs were slightly elevated. Hydroxyproline 31-45 interleukin 1 beta Rattus norvegicus 11-20 8769830-7 1996 to examine whether tyrosine kinase is involved in this pathway, mesangial cells were stimulated by IL-1 beta in the presence of a tyrosine kinase inhibitor genistein. Genistein 156-165 interleukin 1 beta Rattus norvegicus 99-108 8769830-10 1996 Transfection of mesangial cells with a c-jun antisense cDNA and treatment with a pharmacological inhibitor of c-Jun/ AP-1, curcumin, revealed that the induction of c-Jun/AP-1 is essential for the expression of MMP-9 by IL-1 beta. Curcumin 123-131 interleukin 1 beta Rattus norvegicus 219-228 8915032-4 1996 This study was undertaken to investigate the influence of Linomide on IL-1beta induced diabetogenic and hormonal changes in the rat in vivo, and on IL-1beta mediated synthesis of NO and inhibition of insulin secretion in isolated islets of Langerhans ex vivo. roquinimex 58-66 interleukin 1 beta Rattus norvegicus 70-78 8548421-9 1996 Simultaneous treatment with IFN-gamma and TNF-alpha or IL-1 beta induced elaboration of nitrite, an end product of nitric oxide, in rat but not human SMCs. Nitrites 88-95 interleukin 1 beta Rattus norvegicus 55-64 8548421-9 1996 Simultaneous treatment with IFN-gamma and TNF-alpha or IL-1 beta induced elaboration of nitrite, an end product of nitric oxide, in rat but not human SMCs. Nitric Oxide 115-127 interleukin 1 beta Rattus norvegicus 55-64 8665399-0 1996 Release of interleukin-1 beta by dermatan sulfate suppresses hepatocyte growth. Dermatan Sulfate 33-49 interleukin 1 beta Rattus norvegicus 11-29 8924035-3 1996 Of 42 DMV neurons recorded intracellularly, 19 (45%) showed a hyperpolarization following an application of 5.8 x 10(-8) M IL-1 beta, which still persisted in a TTX-containing solution. (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid 6-9 interleukin 1 beta Rattus norvegicus 123-132 8924035-3 1996 Of 42 DMV neurons recorded intracellularly, 19 (45%) showed a hyperpolarization following an application of 5.8 x 10(-8) M IL-1 beta, which still persisted in a TTX-containing solution. Tetrodotoxin 161-164 interleukin 1 beta Rattus norvegicus 123-132 8924035-6 1996 The IL-1 beta-induced hyperpolarization was completely blocked by concurrent perfusion with sodium salicylate. Sodium Salicylate 92-109 interleukin 1 beta Rattus norvegicus 4-13 8924035-8 1996 These findings indicate that IL-1 beta mainly inhibits the vagal motoneurons in the DMV, at least partly through prostaglandin synthesis. (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid 84-87 interleukin 1 beta Rattus norvegicus 29-38 8924035-8 1996 These findings indicate that IL-1 beta mainly inhibits the vagal motoneurons in the DMV, at least partly through prostaglandin synthesis. Prostaglandins 113-126 interleukin 1 beta Rattus norvegicus 29-38 8665399-6 1996 Similarly, more than 10 hr was required after the addition of DS before IL-1 beta mRNA was detected. Dermatan Sulfate 62-64 interleukin 1 beta Rattus norvegicus 72-81 8665399-7 1996 These findings suggest that DS in the medium induced the production of IL-1 beta which, in turn, reduced DNA synthesis in hepatocytes. Dermatan Sulfate 28-30 interleukin 1 beta Rattus norvegicus 71-80 8950312-1 1996 We have recently described impaired IL-1 beta-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis in cholestatic rats and have implicated defective IL-1 beta-mediated hypothalamic generation of PGE2 in this finding. Dinoprostone 210-214 interleukin 1 beta Rattus norvegicus 164-173 8699928-1 1996 We investigated the effect of triptoquinone-A (TQA), an active principal of Triptergium wilfordii, on the induction of nitric oxide synthase (NOS) promoted by endotoxin (LPS) and interleukin-1 beta (IL-1 beta). triptoquinone A 30-45 interleukin 1 beta Rattus norvegicus 179-197 8699928-1 1996 We investigated the effect of triptoquinone-A (TQA), an active principal of Triptergium wilfordii, on the induction of nitric oxide synthase (NOS) promoted by endotoxin (LPS) and interleukin-1 beta (IL-1 beta). triptoquinone A 30-45 interleukin 1 beta Rattus norvegicus 199-208 8699928-1 1996 We investigated the effect of triptoquinone-A (TQA), an active principal of Triptergium wilfordii, on the induction of nitric oxide synthase (NOS) promoted by endotoxin (LPS) and interleukin-1 beta (IL-1 beta). triptoquinone A 47-50 interleukin 1 beta Rattus norvegicus 179-197 8699928-1 1996 We investigated the effect of triptoquinone-A (TQA), an active principal of Triptergium wilfordii, on the induction of nitric oxide synthase (NOS) promoted by endotoxin (LPS) and interleukin-1 beta (IL-1 beta). triptoquinone A 47-50 interleukin 1 beta Rattus norvegicus 199-208 8699928-3 1996 TQA also prevented IL-1 beta-triggered initiation of Arg-induced relaxation and nitrite accumulation. triptoquinone A 0-3 interleukin 1 beta Rattus norvegicus 19-28 8699928-3 1996 TQA also prevented IL-1 beta-triggered initiation of Arg-induced relaxation and nitrite accumulation. Arginine 53-56 interleukin 1 beta Rattus norvegicus 19-28 8699928-3 1996 TQA also prevented IL-1 beta-triggered initiation of Arg-induced relaxation and nitrite accumulation. Nitrites 80-87 interleukin 1 beta Rattus norvegicus 19-28 8699928-4 1996 These results suggest that TQA prevents LPS-or IL-1 beta-promoted induction of NOS in vascular smooth muscle, thus inhibiting development of Arg-induced vasorelaxation. triptoquinone A 27-30 interleukin 1 beta Rattus norvegicus 47-56 8699928-4 1996 These results suggest that TQA prevents LPS-or IL-1 beta-promoted induction of NOS in vascular smooth muscle, thus inhibiting development of Arg-induced vasorelaxation. Arginine 141-144 interleukin 1 beta Rattus norvegicus 47-56 8786002-0 1996 Intravenous interleukin-1-beta-induced inhibition of gastric emptying: involvement of central corticotrophin-releasing factor and prostaglandin pathways in rats. Prostaglandins 130-143 interleukin 1 beta Rattus norvegicus 12-30 8598388-4 1996 Exposure of the RCEC to TNF-alpha, IL-1 beta and IL-6 induced a decline in the TEER, which could be completely abolished by 1 muM of indomethacin, a cyclooxygenase inhibitor. Indomethacin 133-145 interleukin 1 beta Rattus norvegicus 35-44 8809217-1 1996 The purpose of this study was to investigate the role of pyrogenic cytokines, such as IL-1 beta, IL-6 and MIP-1 beta, in the mechanisms underlying the hyperthermic response of rats to central injection of PGE2. Dinoprostone 205-209 interleukin 1 beta Rattus norvegicus 86-95 8809217-3 1996 The significant hyperthermia induced by PGE2 was markedly suppressed by micro-injection of anti-IL-6 and partially attenuated by anti-IL-1 beta. Dinoprostone 40-44 interleukin 1 beta Rattus norvegicus 134-143 8749813-1 1995 Intact adult male rats fed an alcohol [ethanol (EtOH)] diet for 10 days show blunted adrenocorticotropic hormone (ACTH) release in response to immune signals such as the cytokine interleukin-1 beta (IL-1 beta) and endotoxin [lipopolysaccharide (LPS)], as well as to physical stress (mild electroshocks). Alcohols 30-37 interleukin 1 beta Rattus norvegicus 179-197 8597419-3 1995 We further demonstrated that protection against lethal effects due to IL-1-beta or LPS could be produced by treating ADX rats with glucocorticoid in a quantity estimated to be equivalent to corticosterone secretion provoked during stress. Corticosterone 190-204 interleukin 1 beta Rattus norvegicus 70-79 8741743-0 1995 Noradrenaline release in hypothalamus and ACTH secretion induced by central interleukin-1beta. Norepinephrine 0-13 interleukin 1 beta Rattus norvegicus 76-93 8741743-3 1995 IL-1beta induced an early increase in noradrenaline (NA) release in the paraventricular nucleus (PVN) followed by a second long-lasting enhancement starting from 80 min, with a maximum at 140 min (187 +/- 14%). Norepinephrine 38-51 interleukin 1 beta Rattus norvegicus 0-8 8741743-6 1995 IL-1beta increased ACTH levels at 2 and 3 h. Indomethacin (10 mg kg(-1), i.p.) Indomethacin 45-57 interleukin 1 beta Rattus norvegicus 0-8 8749813-5 1995 Blockade of the activity of NO synthase (NOS), the enzyme responsible for NO formation, with the arginine derivative L-N omega nitro-L-arginine-methylester (L-NAME), augmented the ACTH response to IL-1 beta or LPS in both control (C) and EtOH-fed (E) rats. NG-Nitroarginine Methyl Ester 157-163 interleukin 1 beta Rattus norvegicus 197-206 8778906-6 1996 In unanesthetized rats, plasma corticosterone increased shortly following IV or IP IL-1 beta administration, but the peak concentration following IV IL-1 beta was significantly earlier (around 1 h) than that following IP IL-1 beta (around 2 h). Corticosterone 31-45 interleukin 1 beta Rattus norvegicus 83-92 8554509-3 1995 We found that co-stimulation of rat glomerular mesangial cells with platelet-derived growth factor (PGDF-BB) and IL-1 beta/TNF-alpha significantly augments the IL-1 beta/TNF-alpha-induced NGF mRNA levels and NGF synthesis. pgdf-bb 100-107 interleukin 1 beta Rattus norvegicus 160-169 8749813-1 1995 Intact adult male rats fed an alcohol [ethanol (EtOH)] diet for 10 days show blunted adrenocorticotropic hormone (ACTH) release in response to immune signals such as the cytokine interleukin-1 beta (IL-1 beta) and endotoxin [lipopolysaccharide (LPS)], as well as to physical stress (mild electroshocks). Alcohols 30-37 interleukin 1 beta Rattus norvegicus 199-208 8594915-2 1995 Maximal nitrite (NO2(-)) production by cultured neonatal rat cardiac myocytes was achieved with 500 U/ml interleukin-1 beta (IL-1 beta) for 48 h (4.6 +/- 0.3 nmol/1.25 x 10(5) cells; n = 12). Nitrites 8-15 interleukin 1 beta Rattus norvegicus 105-123 8594877-8 1995 When RMC were retreated with genistein and herbimycin A, both inhibited collagenase mRNA induction by IL-1 beta. Genistein 29-38 interleukin 1 beta Rattus norvegicus 102-111 8594877-8 1995 When RMC were retreated with genistein and herbimycin A, both inhibited collagenase mRNA induction by IL-1 beta. herbimycin 43-55 interleukin 1 beta Rattus norvegicus 102-111 8749813-1 1995 Intact adult male rats fed an alcohol [ethanol (EtOH)] diet for 10 days show blunted adrenocorticotropic hormone (ACTH) release in response to immune signals such as the cytokine interleukin-1 beta (IL-1 beta) and endotoxin [lipopolysaccharide (LPS)], as well as to physical stress (mild electroshocks). Ethanol 39-46 interleukin 1 beta Rattus norvegicus 179-197 8594915-2 1995 Maximal nitrite (NO2(-)) production by cultured neonatal rat cardiac myocytes was achieved with 500 U/ml interleukin-1 beta (IL-1 beta) for 48 h (4.6 +/- 0.3 nmol/1.25 x 10(5) cells; n = 12). Nitrites 8-15 interleukin 1 beta Rattus norvegicus 125-134 8594915-2 1995 Maximal nitrite (NO2(-)) production by cultured neonatal rat cardiac myocytes was achieved with 500 U/ml interleukin-1 beta (IL-1 beta) for 48 h (4.6 +/- 0.3 nmol/1.25 x 10(5) cells; n = 12). Nitrogen Dioxide 17-20 interleukin 1 beta Rattus norvegicus 105-123 8749813-1 1995 Intact adult male rats fed an alcohol [ethanol (EtOH)] diet for 10 days show blunted adrenocorticotropic hormone (ACTH) release in response to immune signals such as the cytokine interleukin-1 beta (IL-1 beta) and endotoxin [lipopolysaccharide (LPS)], as well as to physical stress (mild electroshocks). Ethanol 39-46 interleukin 1 beta Rattus norvegicus 199-208 8594915-2 1995 Maximal nitrite (NO2(-)) production by cultured neonatal rat cardiac myocytes was achieved with 500 U/ml interleukin-1 beta (IL-1 beta) for 48 h (4.6 +/- 0.3 nmol/1.25 x 10(5) cells; n = 12). Nitrogen Dioxide 17-20 interleukin 1 beta Rattus norvegicus 125-134 8594930-3 1995 However, depletion of neuronal histamine induced by intraperitoneal injection of 160 mumol/rat alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the suppressive effect on drinking, and enhanced the elevating effect on rectal temperature. alpha-fluoromethylhistidine 95-122 interleukin 1 beta Rattus norvegicus 215-224 8749813-1 1995 Intact adult male rats fed an alcohol [ethanol (EtOH)] diet for 10 days show blunted adrenocorticotropic hormone (ACTH) release in response to immune signals such as the cytokine interleukin-1 beta (IL-1 beta) and endotoxin [lipopolysaccharide (LPS)], as well as to physical stress (mild electroshocks). Ethanol 48-52 interleukin 1 beta Rattus norvegicus 179-197 8594930-4 1995 Intraperitoneal injection of 0.12 nmol/rat IL-1 beta increased hypothalamic histamine turnover rate. Histamine 76-85 interleukin 1 beta Rattus norvegicus 43-52 8594930-6 1995 These results suggest that IL-1 beta may stimulate synthesis and release of hypothalamic histamine in presynaptic terminals by activation of HDC and facilitate degradation of extracellular histamine by activation of MHT. Histamine 89-98 interleukin 1 beta Rattus norvegicus 27-36 8594915-5 1995 The addition of FSK or DBcAMP to IL-1 beta significantly increased NO2-) levels vs. IL-1 beta alone (9.7 +/- 0.6 and 10.9 +/- 0.8 vs. 4.6 +/- 0.3 nmol/1.25 x 10(5) cells per 48 h, respectively; P < 0.01; n = 12). Bucladesine 23-29 interleukin 1 beta Rattus norvegicus 33-42 8594915-5 1995 The addition of FSK or DBcAMP to IL-1 beta significantly increased NO2-) levels vs. IL-1 beta alone (9.7 +/- 0.6 and 10.9 +/- 0.8 vs. 4.6 +/- 0.3 nmol/1.25 x 10(5) cells per 48 h, respectively; P < 0.01; n = 12). Nitrogen Dioxide 67-70 interleukin 1 beta Rattus norvegicus 33-42 8749813-1 1995 Intact adult male rats fed an alcohol [ethanol (EtOH)] diet for 10 days show blunted adrenocorticotropic hormone (ACTH) release in response to immune signals such as the cytokine interleukin-1 beta (IL-1 beta) and endotoxin [lipopolysaccharide (LPS)], as well as to physical stress (mild electroshocks). Ethanol 48-52 interleukin 1 beta Rattus norvegicus 199-208 8594915-7 1995 The addition of FSK or DBcAMP to IL-1 beta increased iNOS mRNA half-life over IL-1 beta treatment alone (10.6, 11.7 vs. 2.4 h, respectively). Colforsin 16-19 interleukin 1 beta Rattus norvegicus 78-87 8594930-6 1995 These results suggest that IL-1 beta may stimulate synthesis and release of hypothalamic histamine in presynaptic terminals by activation of HDC and facilitate degradation of extracellular histamine by activation of MHT. Histamine 189-198 interleukin 1 beta Rattus norvegicus 27-36 8749813-5 1995 Blockade of the activity of NO synthase (NOS), the enzyme responsible for NO formation, with the arginine derivative L-N omega nitro-L-arginine-methylester (L-NAME), augmented the ACTH response to IL-1 beta or LPS in both control (C) and EtOH-fed (E) rats. Arginine 97-105 interleukin 1 beta Rattus norvegicus 197-206 8594930-6 1995 These results suggest that IL-1 beta may stimulate synthesis and release of hypothalamic histamine in presynaptic terminals by activation of HDC and facilitate degradation of extracellular histamine by activation of MHT. 4-METHYL-5-THIAZOLEETHANOL 216-219 interleukin 1 beta Rattus norvegicus 27-36 8594915-7 1995 The addition of FSK or DBcAMP to IL-1 beta increased iNOS mRNA half-life over IL-1 beta treatment alone (10.6, 11.7 vs. 2.4 h, respectively). Bucladesine 23-29 interleukin 1 beta Rattus norvegicus 33-42 8594915-7 1995 The addition of FSK or DBcAMP to IL-1 beta increased iNOS mRNA half-life over IL-1 beta treatment alone (10.6, 11.7 vs. 2.4 h, respectively). Bucladesine 23-29 interleukin 1 beta Rattus norvegicus 78-87 8749813-5 1995 Blockade of the activity of NO synthase (NOS), the enzyme responsible for NO formation, with the arginine derivative L-N omega nitro-L-arginine-methylester (L-NAME), augmented the ACTH response to IL-1 beta or LPS in both control (C) and EtOH-fed (E) rats. l-n omega nitro-l-arginine 117-143 interleukin 1 beta Rattus norvegicus 197-206 8594930-0 1995 Hypothalamic neuronal histamine modulates physiological responses induced by interleukin-1 beta. Histamine 22-31 interleukin 1 beta Rattus norvegicus 77-95 8594930-1 1995 Dynamic involvement of hypothalamic histamine in ingestive behavior and thermogenesis induced by interleukin-1 beta (IL-1 beta) was examined in rats. Histamine 36-45 interleukin 1 beta Rattus norvegicus 97-115 8594930-1 1995 Dynamic involvement of hypothalamic histamine in ingestive behavior and thermogenesis induced by interleukin-1 beta (IL-1 beta) was examined in rats. Histamine 36-45 interleukin 1 beta Rattus norvegicus 117-126 8594930-7 1995 These changes in the dynamics of hypothalamic histamine modulate IL-1 beta-induced ingestive behavior and body temperature. Histamine 46-55 interleukin 1 beta Rattus norvegicus 65-74 8594930-2 1995 Intraperitoneal injection of 0.12 nmol/rat IL-1 beta decreased food and water intake and elevated body temperature. Water 72-77 interleukin 1 beta Rattus norvegicus 43-52 8594930-3 1995 However, depletion of neuronal histamine induced by intraperitoneal injection of 160 mumol/rat alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the suppressive effect on drinking, and enhanced the elevating effect on rectal temperature. Histamine 31-40 interleukin 1 beta Rattus norvegicus 215-224 7588294-7 1995 IL-1 beta, TNF-alpha, and bacterial lipopolysaccharide were found to have weak stimulatory effects on nitrite production on their own. Nitrites 102-109 interleukin 1 beta Rattus norvegicus 0-9 8719114-4 1995 It was found that IL-1 beta exposure induced the production of nitric oxide in beta-cells, but not in alpha-cells. Nitric Oxide 63-75 interleukin 1 beta Rattus norvegicus 18-27 7498650-6 1995 RESULTS: Interleukin 1 beta plus interleukin 6 suppressed 3H release and caused an increase in tissue prostaglandin E2 but not leukotriene E4. Tritium 58-60 interleukin 1 beta Rattus norvegicus 9-27 7498650-6 1995 RESULTS: Interleukin 1 beta plus interleukin 6 suppressed 3H release and caused an increase in tissue prostaglandin E2 but not leukotriene E4. Dinoprostone 102-118 interleukin 1 beta Rattus norvegicus 9-27 7498650-6 1995 RESULTS: Interleukin 1 beta plus interleukin 6 suppressed 3H release and caused an increase in tissue prostaglandin E2 but not leukotriene E4. Leukotriene E4 127-141 interleukin 1 beta Rattus norvegicus 9-27 8751285-0 1995 A study on the role of circulating prostaglandin E2 in the adrenocorticotropin response to intravenous administration of interleukin-1beta in the rat. Dinoprostone 35-51 interleukin 1 beta Rattus norvegicus 121-138 8653552-2 1995 IL-1 beta decreased food and water intake and elevated body temperature. Water 29-34 interleukin 1 beta Rattus norvegicus 0-9 8653552-3 1995 Depletion of neuronal histamine in the hypothalamus induced by alpha-fluoromethylhistidine, a suicide inhibitor of the histamine synthesizing enzyme histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the inhibitory effect on water intake, and enhanced its thermogenic effect. Histamine 22-31 interleukin 1 beta Rattus norvegicus 217-226 8745299-4 1995 Pro-inflammatory cytokines IL-1 alpha and IL-1 beta may also play a significant role in endometrial response via the modulation of prostaglandin E2 production. Dinoprostone 131-147 interleukin 1 beta Rattus norvegicus 42-51 8653552-3 1995 Depletion of neuronal histamine in the hypothalamus induced by alpha-fluoromethylhistidine, a suicide inhibitor of the histamine synthesizing enzyme histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the inhibitory effect on water intake, and enhanced its thermogenic effect. alpha-fluoromethylhistidine 63-90 interleukin 1 beta Rattus norvegicus 217-226 7594493-1 1995 IL-1 beta induces hepatic nitric oxide synthesis. Nitric Oxide 26-38 interleukin 1 beta Rattus norvegicus 0-9 8653552-5 1995 Pretreatment with indomethacin completely blocked those increases in turnover of neuronal histamine induced by IL-1 beta. Indomethacin 18-30 interleukin 1 beta Rattus norvegicus 111-120 8653552-5 1995 Pretreatment with indomethacin completely blocked those increases in turnover of neuronal histamine induced by IL-1 beta. Histamine 90-99 interleukin 1 beta Rattus norvegicus 111-120 8653552-6 1995 Hypothalamic prostaglandin E2 (PGE2) activated by peripheral IL-1 beta, but not peripheral PGE2, increased both activities of HDC and HMT. Dinoprostone 13-29 interleukin 1 beta Rattus norvegicus 61-70 8653552-6 1995 Hypothalamic prostaglandin E2 (PGE2) activated by peripheral IL-1 beta, but not peripheral PGE2, increased both activities of HDC and HMT. Dinoprostone 31-35 interleukin 1 beta Rattus norvegicus 61-70 8653552-7 1995 Ginsenoside Rg1, a major component of panax ginseng, modulated the suppressive effects of IL-1 beta on ingestive behavior, resulting in a lowering of body temperature. Ginsenosides 0-11 interleukin 1 beta Rattus norvegicus 90-99 8653552-8 1995 The findings suggest that the effects of IL-1 beta on ingestive behavior and thermogenesis may be modulated by dynamics of hypothalamic neuronal histamine through activation of hypothalamic PGE2 which is elevated by peripheral IL-1 beta. Histamine 145-154 interleukin 1 beta Rattus norvegicus 41-50 8653552-8 1995 The findings suggest that the effects of IL-1 beta on ingestive behavior and thermogenesis may be modulated by dynamics of hypothalamic neuronal histamine through activation of hypothalamic PGE2 which is elevated by peripheral IL-1 beta. Histamine 145-154 interleukin 1 beta Rattus norvegicus 227-236 8653552-8 1995 The findings suggest that the effects of IL-1 beta on ingestive behavior and thermogenesis may be modulated by dynamics of hypothalamic neuronal histamine through activation of hypothalamic PGE2 which is elevated by peripheral IL-1 beta. Dinoprostone 190-194 interleukin 1 beta Rattus norvegicus 41-50 8653552-8 1995 The findings suggest that the effects of IL-1 beta on ingestive behavior and thermogenesis may be modulated by dynamics of hypothalamic neuronal histamine through activation of hypothalamic PGE2 which is elevated by peripheral IL-1 beta. Dinoprostone 190-194 interleukin 1 beta Rattus norvegicus 227-236 8608789-0 1995 Tumor necrosis factor-alpha prevents interleukin-1 beta from augmenting capsaicin-induced vasodilatation in the rat skin. Capsaicin 72-81 interleukin 1 beta Rattus norvegicus 37-55 8608789-5 1995 This enhancement of the cutaneous hyperaemic response to capsaicin was absent when interleukin-1 beta (50 pg) was co-injected with TNF alpha (500 pg or 5000 pg). Capsaicin 57-66 interleukin 1 beta Rattus norvegicus 83-101 8624721-9 1995 These findings indicate that IL-1 beta in the MPO and the VMH produces hyperalgesia and analgesia, respectively, while, in addition, both effects are mediated by IL-1 receptors and the synthesis of prostaglandins. Prostaglandins 198-212 interleukin 1 beta Rattus norvegicus 29-38 7594493-6 1995 Only IL-1 beta induced high levels of iNOS mRNA and corresponding NO2- + NO3- production, and dexamethasone and cycloheximide blocked a majority of this response. no2- + no3 66-76 interleukin 1 beta Rattus norvegicus 5-14 7589574-3 1995 Treatment of rat mesangial cells with platelet products PDGF-AB, PDGF-BB or serotonin transiently induced MCP-1 expression with a maximum after 2 to 4 h and a decline to baseline after 6 to 8 h. Different kinetics were observed with interleukin-1 beta (IL-1 beta), which induced a long lasting elevation of MCP-1 mRNA for more than 20 h. Together, PDGF and IL-1 beta synergistically induced MCP-1 expression. Serotonin 76-85 interleukin 1 beta Rattus norvegicus 357-366 7488131-0 1995 Interleukin 1 beta-induced expression of nitric oxide synthase in rat renal mesangial cells is suppressed by cyclosporin A. Cyclosporine 109-122 interleukin 1 beta Rattus norvegicus 0-18 7488131-2 1995 Here we report that cyclosporin A (CsA) a potent immunosuppressive drug, inhibits IL-1 beta dependent iNOS expression in renal mesangial cells. Cyclosporine 20-33 interleukin 1 beta Rattus norvegicus 82-91 7488131-2 1995 Here we report that cyclosporin A (CsA) a potent immunosuppressive drug, inhibits IL-1 beta dependent iNOS expression in renal mesangial cells. Cyclosporine 35-38 interleukin 1 beta Rattus norvegicus 82-91 7488131-3 1995 Addition of CsA dose dependently suppresses IL-1 beta-induced nitrite formation (IC50 = 0.9 microM). Cyclosporine 12-15 interleukin 1 beta Rattus norvegicus 44-53 7488131-3 1995 Addition of CsA dose dependently suppresses IL-1 beta-induced nitrite formation (IC50 = 0.9 microM). Nitrites 62-69 interleukin 1 beta Rattus norvegicus 44-53 7488131-4 1995 Western- and Northern blot analyses of mesangial cell extracts reveal that the inhibition of IL-1 beta-induced nitrite formation by CsA is due to decreased iNOS protein and iNOS mRNA steady state levels. Nitrites 111-118 interleukin 1 beta Rattus norvegicus 93-102 7488131-4 1995 Western- and Northern blot analyses of mesangial cell extracts reveal that the inhibition of IL-1 beta-induced nitrite formation by CsA is due to decreased iNOS protein and iNOS mRNA steady state levels. Cyclosporine 132-135 interleukin 1 beta Rattus norvegicus 93-102 7589574-3 1995 Treatment of rat mesangial cells with platelet products PDGF-AB, PDGF-BB or serotonin transiently induced MCP-1 expression with a maximum after 2 to 4 h and a decline to baseline after 6 to 8 h. Different kinetics were observed with interleukin-1 beta (IL-1 beta), which induced a long lasting elevation of MCP-1 mRNA for more than 20 h. Together, PDGF and IL-1 beta synergistically induced MCP-1 expression. Serotonin 76-85 interleukin 1 beta Rattus norvegicus 233-251 7589574-3 1995 Treatment of rat mesangial cells with platelet products PDGF-AB, PDGF-BB or serotonin transiently induced MCP-1 expression with a maximum after 2 to 4 h and a decline to baseline after 6 to 8 h. Different kinetics were observed with interleukin-1 beta (IL-1 beta), which induced a long lasting elevation of MCP-1 mRNA for more than 20 h. Together, PDGF and IL-1 beta synergistically induced MCP-1 expression. Serotonin 76-85 interleukin 1 beta Rattus norvegicus 253-262 7589574-6 1995 Message stabilization also contributed to the synergistic action of PDGF and IL-1 beta: the apparent half life of MCP-1 mRNA determined in the presence of actinomycin D was prolonged when both stimuli were added together. Dactinomycin 155-168 interleukin 1 beta Rattus norvegicus 77-86 7491969-6 1995 In contrast, at dosages 10-fold higher (10 micrograms/kg ip) than that used in the study to inhibit acid secretion, IL-1 beta and yIL-1N7/Q equally reduced (approximately 80%) indomethacin-induced gastric damage, but yIL-1 beta delta 4 was ineffective. Indomethacin 176-188 interleukin 1 beta Rattus norvegicus 116-125 7491936-4 1995 Indomethacin (0.25 mg/100 g ip) reduced IL-1 beta-induced anorexia and tended to normalize NPY concentrations. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 40-49 7586373-10 1995 Phorbol 12-myristate 13-acetate (PMA) also augmented NO synthesis in IL-1 beta-stimulated but not in unstimulated cells in a dose-dependent manner. Tetradecanoylphorbol Acetate 0-31 interleukin 1 beta Rattus norvegicus 69-78 7577464-11 1995 Levels of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) (pg ml-1) were also lowered by carnitine in both LPS (IL-1 beta: 536 +/- 65 vs 378 +/- 44: IL-6: 271 +/- 29 vs 222 +/- 32; TNF-alpha: 618 +/- 86 vs 367 +/- 54, P < or = 0.02) and sarcoma models (IL-1 beta: 423 +/- 33 vs 221 +/- 60; IL-6: 222 +/- 18 vs 139 +/- 38; TNF-alpha: 617 +/- 69 vs 280 +/- 77, P < or = 0.05) for control and carnitine groups respectively. Carnitine 139-148 interleukin 1 beta Rattus norvegicus 10-28 7577464-11 1995 Levels of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) (pg ml-1) were also lowered by carnitine in both LPS (IL-1 beta: 536 +/- 65 vs 378 +/- 44: IL-6: 271 +/- 29 vs 222 +/- 32; TNF-alpha: 618 +/- 86 vs 367 +/- 54, P < or = 0.02) and sarcoma models (IL-1 beta: 423 +/- 33 vs 221 +/- 60; IL-6: 222 +/- 18 vs 139 +/- 38; TNF-alpha: 617 +/- 69 vs 280 +/- 77, P < or = 0.05) for control and carnitine groups respectively. Carnitine 139-148 interleukin 1 beta Rattus norvegicus 30-39 7577464-11 1995 Levels of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) (pg ml-1) were also lowered by carnitine in both LPS (IL-1 beta: 536 +/- 65 vs 378 +/- 44: IL-6: 271 +/- 29 vs 222 +/- 32; TNF-alpha: 618 +/- 86 vs 367 +/- 54, P < or = 0.02) and sarcoma models (IL-1 beta: 423 +/- 33 vs 221 +/- 60; IL-6: 222 +/- 18 vs 139 +/- 38; TNF-alpha: 617 +/- 69 vs 280 +/- 77, P < or = 0.05) for control and carnitine groups respectively. Carnitine 139-148 interleukin 1 beta Rattus norvegicus 162-171 7577464-11 1995 Levels of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) (pg ml-1) were also lowered by carnitine in both LPS (IL-1 beta: 536 +/- 65 vs 378 +/- 44: IL-6: 271 +/- 29 vs 222 +/- 32; TNF-alpha: 618 +/- 86 vs 367 +/- 54, P < or = 0.02) and sarcoma models (IL-1 beta: 423 +/- 33 vs 221 +/- 60; IL-6: 222 +/- 18 vs 139 +/- 38; TNF-alpha: 617 +/- 69 vs 280 +/- 77, P < or = 0.05) for control and carnitine groups respectively. Carnitine 139-148 interleukin 1 beta Rattus norvegicus 162-171 7586373-10 1995 Phorbol 12-myristate 13-acetate (PMA) also augmented NO synthesis in IL-1 beta-stimulated but not in unstimulated cells in a dose-dependent manner. Tetradecanoylphorbol Acetate 33-36 interleukin 1 beta Rattus norvegicus 69-78 7589333-8 1995 These findings suggest that the effects of IL-1 beta and IL-6 on dopaminergic neurons are not mediated by glial proliferation, that IL-1 beta acts as a neurotrophic factor on dopaminergic neurons, and that IL-6 is capable of protecting dopaminergic neurons from the neurotoxicity of MPP+. mangion-purified polysaccharide (Candida albicans) 283-287 interleukin 1 beta Rattus norvegicus 132-141 7573552-5 1995 Dexamethasone pretreatment also inhibited fever induced by centrally injected TNF-alpha, IL-1 beta, or IL-6. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 89-98 8592949-7 1995 The inhibitory effect of 10(-6) M alendronate on PBMC proliferation was reversed by 10 U/ml recombinant rIL-1 beta, whereas other cytokines such as IL-6, TNF-alpha, and granulocyte-macrophage colony-stimulating factor (GM-CSF) had no effect. Alendronate 34-45 interleukin 1 beta Rattus norvegicus 104-114 7472494-10 1995 IL-1 beta-pretreated rats also showed increased ACTH and corticosterone responses to electric footshocks. Corticosterone 57-71 interleukin 1 beta Rattus norvegicus 0-9 7473142-8 1995 In isolated rat aortic smooth muscle cells, LPS or interleukin-1 beta caused prominent rises in nitric oxide generated by iNOS. Nitric Oxide 96-108 interleukin 1 beta Rattus norvegicus 51-69 8643163-7 1995 In addition cell counts revealed that ATP significantly augments MC growth induced by EGF, bFGF, PDGF-BB, ET-1, AVP, Thr, 5-HT, and IL-1 beta. Adenosine Triphosphate 38-41 interleukin 1 beta Rattus norvegicus 132-141 7559661-3 1995 Treatment of rat hepatocytes cultured on matrigel with interleukin-1 beta caused a rapid turnover of sphingomyelin and an increase in cellular ceramide, with no change in cellular phosphatidylcholine. Sphingomyelins 101-114 interleukin 1 beta Rattus norvegicus 55-73 7559661-3 1995 Treatment of rat hepatocytes cultured on matrigel with interleukin-1 beta caused a rapid turnover of sphingomyelin and an increase in cellular ceramide, with no change in cellular phosphatidylcholine. Ceramides 143-151 interleukin 1 beta Rattus norvegicus 55-73 7487987-0 1995 Nicotinamide inhibits IRF-1 mRNA induction and prevents IL-1 beta-induced nitric oxide synthase expression in pancreatic beta cells. Niacinamide 0-12 interleukin 1 beta Rattus norvegicus 56-65 7487987-2 1995 Here, using isolated rat pancreatic islets, we show that high-concentration nicotinamide (20 mM), but not low-concentration nicotinamide (5 mM), attenuates the interleukin-1 beta-evoked inhibition of glucose-induced insulin secretion by preventing the induction of interferon regulatory factor-1, a transcriptional factor which plays an essential role in inducible nitric oxide synthase gene expression, and the interleukin-1 beta-induced nitric oxide formation. Niacinamide 76-88 interleukin 1 beta Rattus norvegicus 160-178 7487987-2 1995 Here, using isolated rat pancreatic islets, we show that high-concentration nicotinamide (20 mM), but not low-concentration nicotinamide (5 mM), attenuates the interleukin-1 beta-evoked inhibition of glucose-induced insulin secretion by preventing the induction of interferon regulatory factor-1, a transcriptional factor which plays an essential role in inducible nitric oxide synthase gene expression, and the interleukin-1 beta-induced nitric oxide formation. Niacinamide 76-88 interleukin 1 beta Rattus norvegicus 412-430 7487987-2 1995 Here, using isolated rat pancreatic islets, we show that high-concentration nicotinamide (20 mM), but not low-concentration nicotinamide (5 mM), attenuates the interleukin-1 beta-evoked inhibition of glucose-induced insulin secretion by preventing the induction of interferon regulatory factor-1, a transcriptional factor which plays an essential role in inducible nitric oxide synthase gene expression, and the interleukin-1 beta-induced nitric oxide formation. Glucose 200-207 interleukin 1 beta Rattus norvegicus 160-178 7487987-2 1995 Here, using isolated rat pancreatic islets, we show that high-concentration nicotinamide (20 mM), but not low-concentration nicotinamide (5 mM), attenuates the interleukin-1 beta-evoked inhibition of glucose-induced insulin secretion by preventing the induction of interferon regulatory factor-1, a transcriptional factor which plays an essential role in inducible nitric oxide synthase gene expression, and the interleukin-1 beta-induced nitric oxide formation. Nitric Oxide 365-377 interleukin 1 beta Rattus norvegicus 160-178 7487987-3 1995 High-concentration nicotinamide also restored an interleukin-1 beta-induced decrease in ATP content in pancreatic beta cells, suggesting that interleukin-1 beta-induced nitric oxide inhibits the mitochondrial function. Niacinamide 19-31 interleukin 1 beta Rattus norvegicus 49-67 7487987-3 1995 High-concentration nicotinamide also restored an interleukin-1 beta-induced decrease in ATP content in pancreatic beta cells, suggesting that interleukin-1 beta-induced nitric oxide inhibits the mitochondrial function. Niacinamide 19-31 interleukin 1 beta Rattus norvegicus 142-160 7487987-3 1995 High-concentration nicotinamide also restored an interleukin-1 beta-induced decrease in ATP content in pancreatic beta cells, suggesting that interleukin-1 beta-induced nitric oxide inhibits the mitochondrial function. Adenosine Triphosphate 88-91 interleukin 1 beta Rattus norvegicus 49-67 7487987-3 1995 High-concentration nicotinamide also restored an interleukin-1 beta-induced decrease in ATP content in pancreatic beta cells, suggesting that interleukin-1 beta-induced nitric oxide inhibits the mitochondrial function. Adenosine Triphosphate 88-91 interleukin 1 beta Rattus norvegicus 142-160 7487987-3 1995 High-concentration nicotinamide also restored an interleukin-1 beta-induced decrease in ATP content in pancreatic beta cells, suggesting that interleukin-1 beta-induced nitric oxide inhibits the mitochondrial function. Nitric Oxide 169-181 interleukin 1 beta Rattus norvegicus 49-67 7487987-3 1995 High-concentration nicotinamide also restored an interleukin-1 beta-induced decrease in ATP content in pancreatic beta cells, suggesting that interleukin-1 beta-induced nitric oxide inhibits the mitochondrial function. Nitric Oxide 169-181 interleukin 1 beta Rattus norvegicus 142-160 8580380-8 1995 We conclude that not only PGE2 but also PGE1 and PGF2 alpha in the brain may mediate the IL-1 beta stimulation of ACTH secretion in the rat. Dinoprostone 26-30 interleukin 1 beta Rattus norvegicus 89-98 8580380-8 1995 We conclude that not only PGE2 but also PGE1 and PGF2 alpha in the brain may mediate the IL-1 beta stimulation of ACTH secretion in the rat. Alprostadil 40-44 interleukin 1 beta Rattus norvegicus 89-98 8580380-8 1995 We conclude that not only PGE2 but also PGE1 and PGF2 alpha in the brain may mediate the IL-1 beta stimulation of ACTH secretion in the rat. Dinoprost 49-53 interleukin 1 beta Rattus norvegicus 89-98 8750796-6 1995 Hypothalamic histamine neurons were activated by high ambient temperature and also by interleukin-1beta, an endogenous pyrogen, through prostaglandin E2 to maintain homeostatic thermoregulation. Dinoprostone 136-152 interleukin 1 beta Rattus norvegicus 86-103 8580380-0 1995 Role of prostaglandins E1, E2 and F2 alpha in the brain in interleukin 1 beta-induced adrenocorticotropin secretion in the rat. Prostaglandins 8-22 interleukin 1 beta Rattus norvegicus 59-77 8543372-3 1995 Compared to unstimulated (UNS) cultures, LPS, IL-1 beta and TNF alpha were found to significantly increase the level of CINC detected in culture by two, four and sixteen hours post stimulation, respectively. Zinc 120-124 interleukin 1 beta Rattus norvegicus 46-55 8543372-5 1995 The accumulation of CINC basolaterally was significantly more than apically; 133%, 45%, 117% and 123% for UNS, IL-1 beta, LPS and TNF alpha respectively. Zinc 20-24 interleukin 1 beta Rattus norvegicus 111-120 7561522-3 1995 In addition, lipopolysaccharide (LPS) was synergistic with IL-1 beta or tumor necrosis factor-alpha (TNF-alpha) in induction of nitric oxide synthesis. Nitric Oxide 128-140 interleukin 1 beta Rattus norvegicus 59-68 7557540-8 1995 gamma-Tocopherol and aminoguanidine, an NO synthase inhibitor, were superior to alpha-tocopherol in preventing RINm5F cell toxicity induced by Interleukin-1 beta (IL-1 beta). gamma-Tocopherol 0-16 interleukin 1 beta Rattus norvegicus 163-172 8590820-0 1995 Behavioral effects of interleukin-1 beta: modulation by gender, estrus cycle, and progesterone. Progesterone 82-94 interleukin 1 beta Rattus norvegicus 22-40 7557540-8 1995 gamma-Tocopherol and aminoguanidine, an NO synthase inhibitor, were superior to alpha-tocopherol in preventing RINm5F cell toxicity induced by Interleukin-1 beta (IL-1 beta). pimagedine 21-35 interleukin 1 beta Rattus norvegicus 143-161 7557540-8 1995 gamma-Tocopherol and aminoguanidine, an NO synthase inhibitor, were superior to alpha-tocopherol in preventing RINm5F cell toxicity induced by Interleukin-1 beta (IL-1 beta). pimagedine 21-35 interleukin 1 beta Rattus norvegicus 163-172 7557540-8 1995 gamma-Tocopherol and aminoguanidine, an NO synthase inhibitor, were superior to alpha-tocopherol in preventing RINm5F cell toxicity induced by Interleukin-1 beta (IL-1 beta). alpha-Tocopherol 80-96 interleukin 1 beta Rattus norvegicus 143-161 7557540-8 1995 gamma-Tocopherol and aminoguanidine, an NO synthase inhibitor, were superior to alpha-tocopherol in preventing RINm5F cell toxicity induced by Interleukin-1 beta (IL-1 beta). rinm5f 111-117 interleukin 1 beta Rattus norvegicus 143-161 7557540-8 1995 gamma-Tocopherol and aminoguanidine, an NO synthase inhibitor, were superior to alpha-tocopherol in preventing RINm5F cell toxicity induced by Interleukin-1 beta (IL-1 beta). rinm5f 111-117 interleukin 1 beta Rattus norvegicus 163-172 7502703-0 1995 Triiodothyronine potentiates the stimulatory effects of interleukin-1 beta on bone resorption and medium interleukin-6 content in fetal rat limb bone cultures. Triiodothyronine 0-16 interleukin 1 beta Rattus norvegicus 56-74 7502703-6 1995 T3, 10(-8) M, also significantly increased IL-1 beta-stimulated calcium release. Calcium 64-71 interleukin 1 beta Rattus norvegicus 43-52 7502703-8 1995 One micromolar indomethacin significantly, but not completely, inhibited the effect of IL-1 beta, as well as the combined effect of IL-1 beta and T3 on resorption and IL-6 production, indicating the involvement of prostaglandins in these actions. Indomethacin 15-27 interleukin 1 beta Rattus norvegicus 87-96 7544359-3 1995 We report that femtomolar levels of IL-1 beta, which alone were non-mitogenic or weakly mitogenic, synergistically increased FGF-2-induced [3H]thymidine incorporation and cell proliferation. Tritium 140-142 interleukin 1 beta Rattus norvegicus 36-45 7502703-8 1995 One micromolar indomethacin significantly, but not completely, inhibited the effect of IL-1 beta, as well as the combined effect of IL-1 beta and T3 on resorption and IL-6 production, indicating the involvement of prostaglandins in these actions. Indomethacin 15-27 interleukin 1 beta Rattus norvegicus 132-141 7544359-6 1995 Stimulation of cells with FGF-2 and IL-1 beta increased both DNA content and proliferation, an observation that was consistent with the thymidine incorporation experiments. Thymidine 136-145 interleukin 1 beta Rattus norvegicus 36-45 7593552-0 1995 Evidence that the interleukin-1 beta-induced prostaglandin E2 release from rat hypothalamus is mediated by type I and type II interleukin-1 receptors. Dinoprostone 45-61 interleukin 1 beta Rattus norvegicus 18-36 7593552-1 1995 Interleukin-1 beta (IL-1 beta) has been shown to specifically increase the release of prostaglandin (PG) E2 from rat hypothalamic explants in short-term experiments. Dinoprostone 86-107 interleukin 1 beta Rattus norvegicus 0-18 7593552-1 1995 Interleukin-1 beta (IL-1 beta) has been shown to specifically increase the release of prostaglandin (PG) E2 from rat hypothalamic explants in short-term experiments. Dinoprostone 86-107 interleukin 1 beta Rattus norvegicus 20-29 7593552-5 1995 The anti-type I mAb reduced both basal and IL-1 beta-stimulated PGE2 release at 10 micrograms/ml, but not at lower concentrations. Dinoprostone 64-68 interleukin 1 beta Rattus norvegicus 43-52 7593552-8 1995 These findings suggest that IL-1 beta controls production and release of PGE2 by the rat hypothalamus via both type I and type II receptors, although the latter appear to be involved only in the response to high levels of IL-1. Dinoprostone 73-77 interleukin 1 beta Rattus norvegicus 28-37 7648713-3 1995 The results show that alveolar macrophages isolated from OM-85-treated rats secreted significantly more nitric oxide, tumour necrosis factor-alpha (TNF-alpha) and IL-1 beta upon in vitro stimulation with lipopolysaccharide (LPS), whereas, in contrast, LPS-induced IL-6 secretion was significantly lower. om-85 57-62 interleukin 1 beta Rattus norvegicus 163-172 7477920-4 1995 Pretreatment of rats with capsaicin or administration of dexamethasone completely prevented the interleukin-1 beta effect. Dexamethasone 57-70 interleukin 1 beta Rattus norvegicus 96-114 8693488-12 1995 HS inhibited the natriuresis mediated by IL-1 beta, despite increases in plasma ANP and had no influence on plasma AVP and MABP. Hydrogen 0-2 interleukin 1 beta Rattus norvegicus 41-50 7477920-4 1995 Pretreatment of rats with capsaicin or administration of dexamethasone completely prevented the interleukin-1 beta effect. Capsaicin 26-35 interleukin 1 beta Rattus norvegicus 96-114 7642545-2 1995 During studies on the regulation of rat ovarian steroidogenic enzymes by interleukin-1 beta (IL-1 beta), we observed substantial metabolism of 25-hydroxycholesterol to two unusual polar products. 25-hydroxycholesterol 143-164 interleukin 1 beta Rattus norvegicus 73-91 7642545-2 1995 During studies on the regulation of rat ovarian steroidogenic enzymes by interleukin-1 beta (IL-1 beta), we observed substantial metabolism of 25-hydroxycholesterol to two unusual polar products. 25-hydroxycholesterol 143-164 interleukin 1 beta Rattus norvegicus 93-102 7642545-7 1995 IL-1 beta-stimulated ovarian 7 alpha-hydroxylase activity (3-10 pmol/min/mg of cellular protein) was nearly 4-fold that of control levels using 25-hydroxycholesterol as substrate. 25-hydroxycholesterol 144-165 interleukin 1 beta Rattus norvegicus 0-9 7642545-8 1995 Activities at or below control levels were observed when IL-1 beta-treated cell sonicates were boiled or assayed in the presence of NADH (rather than NADPH), indicating that involvement of a nonenzymatic process was unlikely. NADP 132-136 interleukin 1 beta Rattus norvegicus 57-66 7642545-8 1995 Activities at or below control levels were observed when IL-1 beta-treated cell sonicates were boiled or assayed in the presence of NADH (rather than NADPH), indicating that involvement of a nonenzymatic process was unlikely. NADP 150-155 interleukin 1 beta Rattus norvegicus 57-66 7642545-9 1995 IL-1 beta-stimulated 7 alpha-hydroxylase activity was inhibited to basal levels by a 10-fold excess of unlabeled 25- or 27-hydroxycholesterol, but not by cholesterol, pregnenolone, progesterone, testosterone, or dehydroepiandrosterone, suggesting that ovarian 7 alpha-hydroxylase is specific for hydroxycholesterols. 25- or 27-hydroxycholesterol 113-141 interleukin 1 beta Rattus norvegicus 0-9 7642545-9 1995 IL-1 beta-stimulated 7 alpha-hydroxylase activity was inhibited to basal levels by a 10-fold excess of unlabeled 25- or 27-hydroxycholesterol, but not by cholesterol, pregnenolone, progesterone, testosterone, or dehydroepiandrosterone, suggesting that ovarian 7 alpha-hydroxylase is specific for hydroxycholesterols. Cholesterol 130-141 interleukin 1 beta Rattus norvegicus 0-9 7642545-9 1995 IL-1 beta-stimulated 7 alpha-hydroxylase activity was inhibited to basal levels by a 10-fold excess of unlabeled 25- or 27-hydroxycholesterol, but not by cholesterol, pregnenolone, progesterone, testosterone, or dehydroepiandrosterone, suggesting that ovarian 7 alpha-hydroxylase is specific for hydroxycholesterols. Progesterone 181-193 interleukin 1 beta Rattus norvegicus 0-9 7642545-9 1995 IL-1 beta-stimulated 7 alpha-hydroxylase activity was inhibited to basal levels by a 10-fold excess of unlabeled 25- or 27-hydroxycholesterol, but not by cholesterol, pregnenolone, progesterone, testosterone, or dehydroepiandrosterone, suggesting that ovarian 7 alpha-hydroxylase is specific for hydroxycholesterols. Testosterone 195-207 interleukin 1 beta Rattus norvegicus 0-9 7642545-9 1995 IL-1 beta-stimulated 7 alpha-hydroxylase activity was inhibited to basal levels by a 10-fold excess of unlabeled 25- or 27-hydroxycholesterol, but not by cholesterol, pregnenolone, progesterone, testosterone, or dehydroepiandrosterone, suggesting that ovarian 7 alpha-hydroxylase is specific for hydroxycholesterols. Dehydroepiandrosterone 212-234 interleukin 1 beta Rattus norvegicus 0-9 7642545-9 1995 IL-1 beta-stimulated 7 alpha-hydroxylase activity was inhibited to basal levels by a 10-fold excess of unlabeled 25- or 27-hydroxycholesterol, but not by cholesterol, pregnenolone, progesterone, testosterone, or dehydroepiandrosterone, suggesting that ovarian 7 alpha-hydroxylase is specific for hydroxycholesterols. Hydroxycholesterols 296-315 interleukin 1 beta Rattus norvegicus 0-9 7642545-10 1995 Furthermore, when IL-1 beta-treated ovarian cultures were incubated with radiolabeled cholesterol or testosterone, no 7 alpha-hydroxylated products were observed. Cholesterol 86-97 interleukin 1 beta Rattus norvegicus 18-27 7642545-10 1995 Furthermore, when IL-1 beta-treated ovarian cultures were incubated with radiolabeled cholesterol or testosterone, no 7 alpha-hydroxylated products were observed. Testosterone 101-113 interleukin 1 beta Rattus norvegicus 18-27 7642545-13 1995 The novel finding of the regulation of a 7 alpha-hydroxylase by IL-1 beta (and tumor necrosis factor alpha) suggests a unique role for cytokines in the regulation of cholesterol metabolism in the ovary and possibly other tissues. Cholesterol 166-177 interleukin 1 beta Rattus norvegicus 64-73 7628352-9 1995 Both adult rat islets exposed to IL-1 beta and human pancreatic islets cultured in the presence of IL-1 beta, tumor necrosis factor-alpha, and IFN gamma were able to use citrulline to regenerate arginine and produce NO. Citrulline 170-180 interleukin 1 beta Rattus norvegicus 33-42 8575535-0 1995 Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Aldosterone 0-11 interleukin 1 beta Rattus norvegicus 91-109 7628352-9 1995 Both adult rat islets exposed to IL-1 beta and human pancreatic islets cultured in the presence of IL-1 beta, tumor necrosis factor-alpha, and IFN gamma were able to use citrulline to regenerate arginine and produce NO. Arginine 195-203 interleukin 1 beta Rattus norvegicus 33-42 7635944-3 1995 IL-1 beta (2 ng/ml, 24 h) increased [3H]leucine incorporation by 30 +/- 4% (P < 0.001, n = 29) and net cellular protein content by 20 +/- 4% (P < 0.001, n = 27), but had no effect on DNA synthesis. Tritium 37-39 interleukin 1 beta Rattus norvegicus 0-9 7635944-3 1995 IL-1 beta (2 ng/ml, 24 h) increased [3H]leucine incorporation by 30 +/- 4% (P < 0.001, n = 29) and net cellular protein content by 20 +/- 4% (P < 0.001, n = 27), but had no effect on DNA synthesis. Leucine 40-47 interleukin 1 beta Rattus norvegicus 0-9 7626076-6 1995 However, in the presence of a cyclooxygenase inhibitor, indomethacin, interleukin-1 beta strongly induced heme oxygenase-1 mRNA. Indomethacin 56-68 interleukin 1 beta Rattus norvegicus 70-88 7626076-8 1995 These data suggest that pro-inflammatory stimuli increase heme oxygenase-1 mRNA expression in rat mesangial cells and that interleukin-1 beta-induced heme oxygenase-1 mRNA level is negatively modulated by PGE2. Dinoprostone 205-209 interleukin 1 beta Rattus norvegicus 123-141 7615197-1 1995 BACKGROUND & AIMS: Interleukin (IL) 1 beta is known to induce a neurally mediated colonic water secretion in vivo. Adenosine Monophosphate 12-15 interleukin 1 beta Rattus norvegicus 23-46 7615197-2 1995 The aim of this study was to investigate the mechanism of action of IL-1 beta on colonic net water flux and the role of tachykinins and nitric oxide. Water 93-98 interleukin 1 beta Rattus norvegicus 68-77 7615197-7 1995 L-arginine reversed the antisecretory effect of L-NMA on IL-1 beta-induced hypersecretion but did not modify the IL-1 beta-induced hypersecretion. Arginine 0-10 interleukin 1 beta Rattus norvegicus 57-66 7615197-7 1995 L-arginine reversed the antisecretory effect of L-NMA on IL-1 beta-induced hypersecretion but did not modify the IL-1 beta-induced hypersecretion. l-nma 48-53 interleukin 1 beta Rattus norvegicus 57-66 7481871-4 1995 IL-1 fragment peptide (163-171) had no effect on gastric ulcer formation in the experimental model, whereas sulfhydryl blocker N-ehtylmaleimide partially blocked the protective effect of IL-1 beta. n-ehtylmaleimide 127-143 interleukin 1 beta Rattus norvegicus 187-196 7481871-6 1995 IL-1 beta also decreased the concentration of molondialdehyde (MDA) in the gastric mucosa after 3 h stress. molondialdehyde 46-61 interleukin 1 beta Rattus norvegicus 0-9 7481871-7 1995 The results suggest that IL-1 beta could effectively lessen the degree of stress-induced gastric mucosal damage, due possibly to the production of endogenous sulfhydryl compounds in the gastric mucosa. Sulfhydryl Compounds 158-178 interleukin 1 beta Rattus norvegicus 25-34 8575535-0 1995 Aldosterone inhibits nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Nitric Oxide 21-33 interleukin 1 beta Rattus norvegicus 91-109 8575535-3 1995 Incubation of the cultures with interleukin-1 beta (10 ng/ml) for 24 h caused a significant increase in nitrite generation. Nitrites 104-111 interleukin 1 beta Rattus norvegicus 32-50 8575535-4 1995 The interleukin-1 beta-induced nitrite production by vascular smooth muscle cells was significantly inhibited by aldosterone in a dose (10(-9) approximately 10(-6) M)-dependent manner. Nitrites 31-38 interleukin 1 beta Rattus norvegicus 4-22 8575535-4 1995 The interleukin-1 beta-induced nitrite production by vascular smooth muscle cells was significantly inhibited by aldosterone in a dose (10(-9) approximately 10(-6) M)-dependent manner. Aldosterone 113-124 interleukin 1 beta Rattus norvegicus 4-22 8575535-7 1995 These results indicate that aldosterone inhibits NO synthesis under interleukin-1 beta-stimulated conditions in vascular smooth muscle cells. Aldosterone 28-39 interleukin 1 beta Rattus norvegicus 68-86 8846404-0 1995 Interleukin 1 beta, but not tumor necrosis factor, enhances neurogenic vasodilatation in the rat skin: involvement of nitric oxide. Nitric Oxide 118-130 interleukin 1 beta Rattus norvegicus 0-18 7543244-3 1995 Because we have shown that tyrosine kinase inhibitors attenuate IL-1 beta-induced cyclooxygenase expression and prostaglandin production, we investigated the effect of tyrosine kinase inhibitors on IL-1 beta-induced nitrite production and iNOS mRNA expression in rat mesangial cells. Nitrites 216-223 interleukin 1 beta Rattus norvegicus 198-207 7543244-4 1995 The tyrosine kinase inhibitors genistein and herbimycin A attenuated IL-1 beta-induced nitrite production in a dose-dependent manner. Genistein 31-40 interleukin 1 beta Rattus norvegicus 69-78 7543244-4 1995 The tyrosine kinase inhibitors genistein and herbimycin A attenuated IL-1 beta-induced nitrite production in a dose-dependent manner. herbimycin 45-57 interleukin 1 beta Rattus norvegicus 69-78 7543244-4 1995 The tyrosine kinase inhibitors genistein and herbimycin A attenuated IL-1 beta-induced nitrite production in a dose-dependent manner. Nitrites 87-94 interleukin 1 beta Rattus norvegicus 69-78 8846404-1 1995 In phenobarbitone-anesthetized rats the effects of interleukin 1 beta (IL-1 beta) and tumor necrosis factors (TNFs) were examined on the capsaicin-induced increase of plantar cutaneous blood flow in the rat hind paw as measured by laser Doppler flowmetry. Capsaicin 137-146 interleukin 1 beta Rattus norvegicus 51-69 8846404-6 1995 did not alter the capsaicin-induced vasodilatation but prevented IL-1 beta (50 pg) from augmenting the hyperemic response to capsaicin. Capsaicin 125-134 interleukin 1 beta Rattus norvegicus 65-74 8846404-7 1995 Likewise, blockade of nitric oxide formation by NG-nitro-L-arginine methyl ester (L-NAME) failed to affect the capsaicin-evoked vasodilatation but abolished its amplification by IL-1 beta. NG-Nitroarginine Methyl Ester 82-88 interleukin 1 beta Rattus norvegicus 178-187 8846404-1 1995 In phenobarbitone-anesthetized rats the effects of interleukin 1 beta (IL-1 beta) and tumor necrosis factors (TNFs) were examined on the capsaicin-induced increase of plantar cutaneous blood flow in the rat hind paw as measured by laser Doppler flowmetry. Capsaicin 137-146 interleukin 1 beta Rattus norvegicus 71-80 8846404-8 1995 Systemic pretreatment with a neurotoxic dose of capsaicin reduced the capsaicin-induced hyperemia and prevented the facilitatory effect of IL-1 beta. Capsaicin 48-57 interleukin 1 beta Rattus norvegicus 139-148 8846404-3 1995 IL-1 beta was without effect on blood flow by its own but dose dependently enhanced the hyperemia due to capsaicin (0.3 microgram). Capsaicin 105-114 interleukin 1 beta Rattus norvegicus 0-9 8846404-10 1995 These data indicate that IL-1 beta but not TNF enhances the cutaneous hyperemic response to capsaicin. Capsaicin 92-101 interleukin 1 beta Rattus norvegicus 25-34 7540548-13 1995 Treatment with IL-1 beta also stimulated a small increase in the production of cAMP, estrogen, and progesterone. Progesterone 99-111 interleukin 1 beta Rattus norvegicus 15-24 7556978-1 1995 In vitro exposure of rat pancreatic beta cells to interleukin-1 beta (IL-1 beta) inhibits glucose-stimulated insulin release (2140 +/- 239 and 323 +/- 80 pg.islet-1.h-1 at glucose levels of 16.7 mmol/l in control and IL-1 beta-exposed islets, respectively, n = 7, p < 0.001). Glucose 90-97 interleukin 1 beta Rattus norvegicus 50-68 7556978-1 1995 In vitro exposure of rat pancreatic beta cells to interleukin-1 beta (IL-1 beta) inhibits glucose-stimulated insulin release (2140 +/- 239 and 323 +/- 80 pg.islet-1.h-1 at glucose levels of 16.7 mmol/l in control and IL-1 beta-exposed islets, respectively, n = 7, p < 0.001). Glucose 90-97 interleukin 1 beta Rattus norvegicus 70-79 7556978-1 1995 In vitro exposure of rat pancreatic beta cells to interleukin-1 beta (IL-1 beta) inhibits glucose-stimulated insulin release (2140 +/- 239 and 323 +/- 80 pg.islet-1.h-1 at glucose levels of 16.7 mmol/l in control and IL-1 beta-exposed islets, respectively, n = 7, p < 0.001). Glucose 90-97 interleukin 1 beta Rattus norvegicus 217-226 7556978-1 1995 In vitro exposure of rat pancreatic beta cells to interleukin-1 beta (IL-1 beta) inhibits glucose-stimulated insulin release (2140 +/- 239 and 323 +/- 80 pg.islet-1.h-1 at glucose levels of 16.7 mmol/l in control and IL-1 beta-exposed islets, respectively, n = 7, p < 0.001). Glucose 172-179 interleukin 1 beta Rattus norvegicus 50-68 7556978-1 1995 In vitro exposure of rat pancreatic beta cells to interleukin-1 beta (IL-1 beta) inhibits glucose-stimulated insulin release (2140 +/- 239 and 323 +/- 80 pg.islet-1.h-1 at glucose levels of 16.7 mmol/l in control and IL-1 beta-exposed islets, respectively, n = 7, p < 0.001). Glucose 172-179 interleukin 1 beta Rattus norvegicus 70-79 7556978-2 1995 Cholera toxin (2 micrograms/ml) or pertussis toxin (0.5 microgram/ml) potentiated, as expected, glucose-induced insulin release in control islets, but, in addition, when added together with IL-1 beta, were able to prevent the IL-1 beta mediated inhibition of glucose-stimulated insulin secretion (2087 +/- 301 and 1662 +/- 173 pg.islet-1.h-1, respectively, p < 0.05 vs islets exposed to IL-1 beta alone). Glucose 96-103 interleukin 1 beta Rattus norvegicus 190-199 7556978-2 1995 Cholera toxin (2 micrograms/ml) or pertussis toxin (0.5 microgram/ml) potentiated, as expected, glucose-induced insulin release in control islets, but, in addition, when added together with IL-1 beta, were able to prevent the IL-1 beta mediated inhibition of glucose-stimulated insulin secretion (2087 +/- 301 and 1662 +/- 173 pg.islet-1.h-1, respectively, p < 0.05 vs islets exposed to IL-1 beta alone). Glucose 96-103 interleukin 1 beta Rattus norvegicus 226-235 7556978-2 1995 Cholera toxin (2 micrograms/ml) or pertussis toxin (0.5 microgram/ml) potentiated, as expected, glucose-induced insulin release in control islets, but, in addition, when added together with IL-1 beta, were able to prevent the IL-1 beta mediated inhibition of glucose-stimulated insulin secretion (2087 +/- 301 and 1662 +/- 173 pg.islet-1.h-1, respectively, p < 0.05 vs islets exposed to IL-1 beta alone). Glucose 96-103 interleukin 1 beta Rattus norvegicus 226-235 7540573-1 1995 An inducible nitric oxide (NO) synthase isoform (iNOS) is specifically induced in the beta-cells of interleukin (IL)-1 beta-exposed rat islets, suggesting a role for NO in the pathogenesis of type I diabetes. Nitric Oxide 13-25 interleukin 1 beta Rattus norvegicus 100-123 7540573-4 1995 Addition of IL-1 beta alone or in combination with tumor necrosis factor-alpha induced a concentration- and time-dependent expression of the iNOS gene and associated NO production (measured as nitrite) from both islets and RIN cells. Nitrites 193-200 interleukin 1 beta Rattus norvegicus 12-21 7540548-0 1995 Interleukin-1 beta suppresses apoptosis in rat ovarian follicles by increasing nitric oxide production. Nitric Oxide 79-91 interleukin 1 beta Rattus norvegicus 0-18 7540548-2 1995 Furthermore, induction of nitric oxide (NO) by IL-1 beta has been reported in a wide variety of tissues. Nitric Oxide 26-38 interleukin 1 beta Rattus norvegicus 47-56 7540548-10 1995 Moreover, the addition of NG-monomethyl-L-arginine, a NO synthase inhibitor, reversed both IL-1 beta stimulation of NO production and suppression of apoptosis, suggesting a mediatory role of NO in these IL-1 beta effects. omega-N-Methylarginine 26-50 interleukin 1 beta Rattus norvegicus 91-100 7540548-10 1995 Moreover, the addition of NG-monomethyl-L-arginine, a NO synthase inhibitor, reversed both IL-1 beta stimulation of NO production and suppression of apoptosis, suggesting a mediatory role of NO in these IL-1 beta effects. omega-N-Methylarginine 26-50 interleukin 1 beta Rattus norvegicus 203-212 7540548-13 1995 Treatment with IL-1 beta also stimulated a small increase in the production of cAMP, estrogen, and progesterone. Cyclic AMP 79-83 interleukin 1 beta Rattus norvegicus 15-24 7556978-4 1995 Nitrite levels in the culture medium were 4.2 +/- 1.4 and 24.0 +/- 5 pmol.islet-1.24 h-1 in control islets and in IL-1 beta-exposed islets, respectively (n = 6, p = 0.05). Nitrites 0-7 interleukin 1 beta Rattus norvegicus 114-123 7556978-5 1995 In islets exposed to IL-1 beta and cholera or pertussis toxins, nitrite levels were 9.1 +/- 3 and 12.4 +/- 6 pmol.islet-1.24 h-1, respectively (n = 6, NS vs control islets). Nitrites 64-71 interleukin 1 beta Rattus norvegicus 21-30 7540548-14 1995 Taken together, these findings suggest that IL-1 beta is a survival factor for ovarian follicles, and its action is partially mediated via NO and cGMP generation. Cyclic GMP 146-150 interleukin 1 beta Rattus norvegicus 44-53 7655348-3 1995 Kainic acid causes an increase in metallothionein-I and heme oxygenase-I mRNAs, as well as an increase in c-fos, heat shock protein-70, and interleukin-1 beta mRNAs. Kainic Acid 0-11 interleukin 1 beta Rattus norvegicus 140-158 7478305-2 1995 The present in vitro studies using northern blot analysis showed that the beta-adrenoceptor agonist isoproterenol (1 x 10(-8) to 1 x 10(-5) M) caused a marked induction of IL-1 beta mRNA in microglia, but not in astrocytes. Isoproterenol 100-113 interleukin 1 beta Rattus norvegicus 172-181 7478305-4 1995 These phenomena were confirmed by in situ hybridization with digoxigenin-labelled IL-1 beta RNA probe. Digoxigenin 61-72 interleukin 1 beta Rattus norvegicus 82-91 7478305-5 1995 Furthermore, dibutyryl cyclicAMP (dbcAMP) (5 x 10(-4) and 5 x 10(-5) M) markedly induced IL-1 beta mRNA in microglia. Bucladesine 13-32 interleukin 1 beta Rattus norvegicus 89-98 7478305-5 1995 Furthermore, dibutyryl cyclicAMP (dbcAMP) (5 x 10(-4) and 5 x 10(-5) M) markedly induced IL-1 beta mRNA in microglia. Bucladesine 34-40 interleukin 1 beta Rattus norvegicus 89-98 7478305-7 1995 The induction of IL-1 beta mRNA by either isoproterenol or dbcAMP was strongly inhibited by a cAMP-dependent protein kinase inhibitor, H8. Isoproterenol 42-55 interleukin 1 beta Rattus norvegicus 17-26 7478305-7 1995 The induction of IL-1 beta mRNA by either isoproterenol or dbcAMP was strongly inhibited by a cAMP-dependent protein kinase inhibitor, H8. Bucladesine 59-65 interleukin 1 beta Rattus norvegicus 17-26 7478305-8 1995 These results, taken together, suggest that (1) microglia primarily induce IL-1 beta mRNA by stimulation of beta-adrenoceptors, and (2) cAMP and cAMP-dependent protein kinase presumably participate in a signal transduction mechanism involved in the induction of IL-1 beta mRNA via beta-adrenoceptors. Cyclic AMP 136-140 interleukin 1 beta Rattus norvegicus 262-271 7615784-7 1995 In the presence of L-arginine, but not D-arginine, IL-1 beta, an inducer of inducible NO synthase, also inhibited AII-induced SMC migration, and this effect was prevented by the NO-synthase inhibitor, N-nitro-L-arginine methyl ester. Arginine 19-29 interleukin 1 beta Rattus norvegicus 51-60 7615784-7 1995 In the presence of L-arginine, but not D-arginine, IL-1 beta, an inducer of inducible NO synthase, also inhibited AII-induced SMC migration, and this effect was prevented by the NO-synthase inhibitor, N-nitro-L-arginine methyl ester. n-nitro-l-arginine methyl ester 201-232 interleukin 1 beta Rattus norvegicus 51-60 7655348-7 1995 In addition, the induction of interleukin-1 beta gene expression suggests an inflammatory response in brain regions damaged by kainic acid-induced seizures. Kainic Acid 127-138 interleukin 1 beta Rattus norvegicus 30-48 8963751-13 1995 IL-1 beta administration caused the expected decrease in LH and testosterone levels, but was also accompanied by a loss of testicular responsiveness to gonadotropins. Luteinizing Hormone 57-59 interleukin 1 beta Rattus norvegicus 0-9 8963751-13 1995 IL-1 beta administration caused the expected decrease in LH and testosterone levels, but was also accompanied by a loss of testicular responsiveness to gonadotropins. Testosterone 64-76 interleukin 1 beta Rattus norvegicus 0-9 8963751-20 1995 This brief review discusses the hypothesis that there are brain-to-gonad connections that bypass the pituitary, and presents results that might support the possibility that central injection of IL-1 beta decreases testosterone secretion independently of blunted LH levels. Testosterone 214-226 interleukin 1 beta Rattus norvegicus 194-203 7789536-0 1995 Interleukin-1 beta antagonizes phenobarbital induction of several major cytochromes P450 in adult rat hepatocytes in primary culture. Phenobarbital 31-44 interleukin 1 beta Rattus norvegicus 0-18 7566434-4 1995 In vitro, Il-1 alpha (0.2 ng/ml), IL-1 beta (0.5 ng/ml), IL-6 (10 ng/ml) and IL-8 (1 ng/ml) each caused significant increases in the release of immunoreactive (ir)-CRF-41 and ir-AVP from hypothalami removed from rats adrenalectomized 10-12 days before autopsy; these responses were readily inhibited by preincubation of the tissue with dexamethasone (10(-7) M). Dexamethasone 336-349 interleukin 1 beta Rattus norvegicus 34-43 7566434-6 1995 IL-1 alpha (0.2 ng/ml), IL-1 beta (0.5 ng/ml) and IL-6 (10 ng/ml) also initiated similar increases in the release of CRF-41 and AVP from hypothalami from intact rats which were effectively blocked by dexamethasone (10(-7) M). Dexamethasone 200-213 interleukin 1 beta Rattus norvegicus 24-33 7566434-10 1995 In the NSS-treated groups, dexamethasone (100 micrograms/kg), which had no effect on the prestress concentrations of ACTH and corticosterone in the blood, completely prevented the HPA responses to both IL-1 beta and laparotomy. 5'-O-[N-(L-ASPARAGINYL)SULFAMOYL]ADENOSINE 7-10 interleukin 1 beta Rattus norvegicus 202-211 7566434-10 1995 In the NSS-treated groups, dexamethasone (100 micrograms/kg), which had no effect on the prestress concentrations of ACTH and corticosterone in the blood, completely prevented the HPA responses to both IL-1 beta and laparotomy. Dexamethasone 27-40 interleukin 1 beta Rattus norvegicus 202-211 7556406-3 1995 Inhibition of gastric acid secretion induced by interleukin-1 beta (50 ng/animal) was abolished both by splanchnectomy and by phentolamine (5 mg/kg i.m.). Phentolamine 126-138 interleukin 1 beta Rattus norvegicus 48-66 7556406-5 1995 The interleukin-1 beta (50 ng/animal)-induced inhibition was also abolished by intracerebroventricular pretreatment with indomethacin (500 micrograms/animal), while pretreatment with the same dose of this reagent by the intraperitoneal route was without effect. Indomethacin 121-133 interleukin 1 beta Rattus norvegicus 4-22 7556406-6 1995 These results suggest that centrally administered interleukin-1 beta induces a prostaglandin-mediated central excitation of the sympatho-adrenomedullary system, and the resultant activation of gastric alpha-adrenoceptors inhibits the vagally stimulated gastric acid secretion in rats. Prostaglandins 79-92 interleukin 1 beta Rattus norvegicus 50-68 7552306-0 1995 Inhibition of serotonin-induced Ca2+ mobilization by interleukin-1 beta in rat C6BU-1 glioma cells. Serotonin 14-23 interleukin 1 beta Rattus norvegicus 53-71 7552306-5 1995 The inhibitory effects of IL-1 beta and LPS were significantly prevented by genistein, a selective tyrosine kinase antagonist, and by H7, a potent inhibitor of protein kinase C. These results indicate that IL-1 beta and LPS inhibit 5-HT2 receptor-mediated Ca2+ mobilization via pathways that include the activation of a tyrosine kinase and protein kinase C. The interaction between cytokines (IL-1 beta) and monoamines (5-HT) may serve to modulate signal transduction in the central nervous system. Genistein 76-85 interleukin 1 beta Rattus norvegicus 206-215 7552306-5 1995 The inhibitory effects of IL-1 beta and LPS were significantly prevented by genistein, a selective tyrosine kinase antagonist, and by H7, a potent inhibitor of protein kinase C. These results indicate that IL-1 beta and LPS inhibit 5-HT2 receptor-mediated Ca2+ mobilization via pathways that include the activation of a tyrosine kinase and protein kinase C. The interaction between cytokines (IL-1 beta) and monoamines (5-HT) may serve to modulate signal transduction in the central nervous system. Genistein 76-85 interleukin 1 beta Rattus norvegicus 206-215 7552306-5 1995 The inhibitory effects of IL-1 beta and LPS were significantly prevented by genistein, a selective tyrosine kinase antagonist, and by H7, a potent inhibitor of protein kinase C. These results indicate that IL-1 beta and LPS inhibit 5-HT2 receptor-mediated Ca2+ mobilization via pathways that include the activation of a tyrosine kinase and protein kinase C. The interaction between cytokines (IL-1 beta) and monoamines (5-HT) may serve to modulate signal transduction in the central nervous system. monoamines 408-418 interleukin 1 beta Rattus norvegicus 26-35 7552306-5 1995 The inhibitory effects of IL-1 beta and LPS were significantly prevented by genistein, a selective tyrosine kinase antagonist, and by H7, a potent inhibitor of protein kinase C. These results indicate that IL-1 beta and LPS inhibit 5-HT2 receptor-mediated Ca2+ mobilization via pathways that include the activation of a tyrosine kinase and protein kinase C. The interaction between cytokines (IL-1 beta) and monoamines (5-HT) may serve to modulate signal transduction in the central nervous system. monoamines 408-418 interleukin 1 beta Rattus norvegicus 206-215 7552306-5 1995 The inhibitory effects of IL-1 beta and LPS were significantly prevented by genistein, a selective tyrosine kinase antagonist, and by H7, a potent inhibitor of protein kinase C. These results indicate that IL-1 beta and LPS inhibit 5-HT2 receptor-mediated Ca2+ mobilization via pathways that include the activation of a tyrosine kinase and protein kinase C. The interaction between cytokines (IL-1 beta) and monoamines (5-HT) may serve to modulate signal transduction in the central nervous system. monoamines 408-418 interleukin 1 beta Rattus norvegicus 206-215 7789536-3 1995 Strikingly, IL1 beta strongly inhibited basal EROD and PROD activities, and fully blocked their induction by PB in a dose-dependent fashion. Phenobarbital 109-111 interleukin 1 beta Rattus norvegicus 12-20 7789536-5 1995 Our results demonstrate that IL1 beta can suppress basal CYP activities, as well as PB-inducible expression of five CYP mRNAs in rat hepatocytes in primary culture. Phenobarbital 84-86 interleukin 1 beta Rattus norvegicus 29-37 7552306-5 1995 The inhibitory effects of IL-1 beta and LPS were significantly prevented by genistein, a selective tyrosine kinase antagonist, and by H7, a potent inhibitor of protein kinase C. These results indicate that IL-1 beta and LPS inhibit 5-HT2 receptor-mediated Ca2+ mobilization via pathways that include the activation of a tyrosine kinase and protein kinase C. The interaction between cytokines (IL-1 beta) and monoamines (5-HT) may serve to modulate signal transduction in the central nervous system. Genistein 76-85 interleukin 1 beta Rattus norvegicus 26-35 7544689-4 1995 RESULTS: Incubation of cardiac myocytes for 24 h with IL-1 beta (10 ng.ml-1) or LPS (1 microgram.ml-1) caused significant increases in NO and cGMP production. Cyclic GMP 142-146 interleukin 1 beta Rattus norvegicus 54-63 7541949-6 1995 Preincubation of BBECs with actinomycin D or dexamethasone also blocked rTNF-alpha- and rIL-1 beta-induced cilia stimulation, suggesting that new protein synthesis is required for cytokine-induced upregulation of CBF. bbecs 17-22 interleukin 1 beta Rattus norvegicus 88-98 7541949-6 1995 Preincubation of BBECs with actinomycin D or dexamethasone also blocked rTNF-alpha- and rIL-1 beta-induced cilia stimulation, suggesting that new protein synthesis is required for cytokine-induced upregulation of CBF. Dactinomycin 28-41 interleukin 1 beta Rattus norvegicus 88-98 7541949-6 1995 Preincubation of BBECs with actinomycin D or dexamethasone also blocked rTNF-alpha- and rIL-1 beta-induced cilia stimulation, suggesting that new protein synthesis is required for cytokine-induced upregulation of CBF. Dexamethasone 45-58 interleukin 1 beta Rattus norvegicus 88-98 7661877-0 1995 Cysteinyl-leukotriene D4 induced IL-1 beta expression and release in rat vascular smooth muscle cells. cysteinyl-leukotriene d4 0-24 interleukin 1 beta Rattus norvegicus 33-42 7661877-3 1995 In this study the effects of cysteinyl-leukotriene D4 (LTD4) on IL-1 beta production and IL-1 beta mRNA expression were tested on rat VSMC. cysteinyl-leukotriene d4 29-53 interleukin 1 beta Rattus norvegicus 64-73 7661877-3 1995 In this study the effects of cysteinyl-leukotriene D4 (LTD4) on IL-1 beta production and IL-1 beta mRNA expression were tested on rat VSMC. Leukotriene D4 55-59 interleukin 1 beta Rattus norvegicus 64-73 7661877-6 1995 The production of IL-1 beta was inhibited by MK-571 (from 145 +/- 12 to 60 +/- 10 pg/ml), a specific receptor antagonist of LTD4 and partially reduced by IL-1 receptor antagonist (IL-1 ra) (from 160 +/- 12 to 85 +/- 5 pg/ml). verlukast 45-51 interleukin 1 beta Rattus norvegicus 18-27 7544689-1 1995 OBJECTIVE: The aim was to investigate nitric oxide (NO) synthase activity in cultured neonatal rat cardiac myocytes and fibroblasts upon treatment with inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), IL-2, IL-6, IL-8, transforming growth factor beta (TGF-beta) and gram negative bacterial lipopolysaccharide (LPS). Nitric Oxide 38-50 interleukin 1 beta Rattus norvegicus 175-193 7544689-1 1995 OBJECTIVE: The aim was to investigate nitric oxide (NO) synthase activity in cultured neonatal rat cardiac myocytes and fibroblasts upon treatment with inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), IL-2, IL-6, IL-8, transforming growth factor beta (TGF-beta) and gram negative bacterial lipopolysaccharide (LPS). Nitric Oxide 38-50 interleukin 1 beta Rattus norvegicus 195-204 7544689-6 1995 IL-1 beta induced NO and cGMP production in a time and dose dependent manner. Cyclic GMP 25-29 interleukin 1 beta Rattus norvegicus 0-9 7544689-8 1995 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine, genistein, calphostin C, cycloheximide, or actinomycin D completely inhibited the IL-1 beta induced NO production by cardiac myocytes. omega-N-Methylarginine 42-66 interleukin 1 beta Rattus norvegicus 27-36 7544689-8 1995 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine, genistein, calphostin C, cycloheximide, or actinomycin D completely inhibited the IL-1 beta induced NO production by cardiac myocytes. omega-N-Methylarginine 42-66 interleukin 1 beta Rattus norvegicus 150-159 7544689-8 1995 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine, genistein, calphostin C, cycloheximide, or actinomycin D completely inhibited the IL-1 beta induced NO production by cardiac myocytes. Genistein 68-77 interleukin 1 beta Rattus norvegicus 27-36 7544689-8 1995 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine, genistein, calphostin C, cycloheximide, or actinomycin D completely inhibited the IL-1 beta induced NO production by cardiac myocytes. Genistein 68-77 interleukin 1 beta Rattus norvegicus 150-159 7544689-8 1995 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine, genistein, calphostin C, cycloheximide, or actinomycin D completely inhibited the IL-1 beta induced NO production by cardiac myocytes. calphostin C 79-91 interleukin 1 beta Rattus norvegicus 27-36 7544689-8 1995 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine, genistein, calphostin C, cycloheximide, or actinomycin D completely inhibited the IL-1 beta induced NO production by cardiac myocytes. calphostin C 79-91 interleukin 1 beta Rattus norvegicus 150-159 7544689-8 1995 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine, genistein, calphostin C, cycloheximide, or actinomycin D completely inhibited the IL-1 beta induced NO production by cardiac myocytes. Cycloheximide 93-106 interleukin 1 beta Rattus norvegicus 27-36 7544689-8 1995 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine, genistein, calphostin C, cycloheximide, or actinomycin D completely inhibited the IL-1 beta induced NO production by cardiac myocytes. Cycloheximide 93-106 interleukin 1 beta Rattus norvegicus 150-159 7544689-8 1995 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine, genistein, calphostin C, cycloheximide, or actinomycin D completely inhibited the IL-1 beta induced NO production by cardiac myocytes. Dactinomycin 111-124 interleukin 1 beta Rattus norvegicus 27-36 7544689-8 1995 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine, genistein, calphostin C, cycloheximide, or actinomycin D completely inhibited the IL-1 beta induced NO production by cardiac myocytes. Dactinomycin 111-124 interleukin 1 beta Rattus norvegicus 150-159 7544689-9 1995 TGF-beta, dexamethasone, or cyclosporin A also dose dependently inhibited the IL-1 beta induced NO production. Dexamethasone 10-23 interleukin 1 beta Rattus norvegicus 78-87 7544689-9 1995 TGF-beta, dexamethasone, or cyclosporin A also dose dependently inhibited the IL-1 beta induced NO production. Cyclosporine 28-41 interleukin 1 beta Rattus norvegicus 78-87 7556877-4 1995 Moreover, rIL-1 beta also enhanced the effects of 1 mu/ml glipizide on insulin release, but failed to increase insulin release induced by 30 mM KCl or by glucose plus phorbol ester (TPA; 100 nM). Glipizide 58-67 interleukin 1 beta Rattus norvegicus 10-20 7556877-5 1995 These early stimulatory effects of rIL-1 beta on insulin release were neither accompanied by major increases in glucose or amino acid metabolism, nor by modifications in islet cAMP content, and they were prevented by mannoheptulose, diazoxide or verapamil. Mannoheptulose 217-231 interleukin 1 beta Rattus norvegicus 35-45 7556877-5 1995 These early stimulatory effects of rIL-1 beta on insulin release were neither accompanied by major increases in glucose or amino acid metabolism, nor by modifications in islet cAMP content, and they were prevented by mannoheptulose, diazoxide or verapamil. Diazoxide 233-242 interleukin 1 beta Rattus norvegicus 35-45 7556877-5 1995 These early stimulatory effects of rIL-1 beta on insulin release were neither accompanied by major increases in glucose or amino acid metabolism, nor by modifications in islet cAMP content, and they were prevented by mannoheptulose, diazoxide or verapamil. Verapamil 246-255 interleukin 1 beta Rattus norvegicus 35-45 7556877-6 1995 rIL-1 beta potentiation of glucose-induced insulin release was not accompanied by modifications in [Ca2+]i, but the cytokine increased diacylglycerol production and induced protein kinase C (PKC) activation. Glucose 27-34 interleukin 1 beta Rattus norvegicus 0-10 7556877-7 1995 Down-regulation of PKC completely prevented the stimulatory effects of rIL-1 beta on glucose-induced insulin release. Glucose 85-92 interleukin 1 beta Rattus norvegicus 71-81 7637265-0 1995 IL-1 beta regulates rat mesangial cyclooxygenase II gene expression by tyrosine phosphorylation. Tyrosine 71-79 interleukin 1 beta Rattus norvegicus 0-9 8685078-2 1995 CLS.H2O given by the oral route (300 mg kg(-1)) significantly reduced neutrophil infiltration into the airway lumen induced by intratracheal injection of IL-1 beta in rats. Chlorine 0-3 interleukin 1 beta Rattus norvegicus 154-163 8685078-2 1995 CLS.H2O given by the oral route (300 mg kg(-1)) significantly reduced neutrophil infiltration into the airway lumen induced by intratracheal injection of IL-1 beta in rats. Water 4-7 interleukin 1 beta Rattus norvegicus 154-163 7762028-11 1995 In a closely related model of perinatal brain injury elicited by focal intracerebral N-methyl-D-aspartate injection, there was a corresponding acute stimulation of IL-1 beta and TNF-alpha mRNA expression at 4 hours after injection. N-Methylaspartate 85-105 interleukin 1 beta Rattus norvegicus 164-173 7538755-0 1995 Ethanol potentiates interleukin-1 beta-stimulated inducible nitric oxide synthase expression in cultured vascular smooth muscle cells. Ethanol 0-7 interleukin 1 beta Rattus norvegicus 20-38 7538755-1 1995 Experiments were performed to examine the effect of ethanol on the production of nitric oxide from interleukin-1 beta (IL-1 beta)-treated cultured rat aortic smooth muscle cells. Ethanol 52-59 interleukin 1 beta Rattus norvegicus 99-117 7538755-1 1995 Experiments were performed to examine the effect of ethanol on the production of nitric oxide from interleukin-1 beta (IL-1 beta)-treated cultured rat aortic smooth muscle cells. Ethanol 52-59 interleukin 1 beta Rattus norvegicus 119-128 7538755-1 1995 Experiments were performed to examine the effect of ethanol on the production of nitric oxide from interleukin-1 beta (IL-1 beta)-treated cultured rat aortic smooth muscle cells. Nitric Oxide 81-93 interleukin 1 beta Rattus norvegicus 99-117 7538755-1 1995 Experiments were performed to examine the effect of ethanol on the production of nitric oxide from interleukin-1 beta (IL-1 beta)-treated cultured rat aortic smooth muscle cells. Nitric Oxide 81-93 interleukin 1 beta Rattus norvegicus 119-128 7538755-2 1995 Incubation of vascular smooth muscle cells with IL-1 beta resulted in the release of nitrite and in the intracellular accumulation of L-citrulline. Nitrites 85-92 interleukin 1 beta Rattus norvegicus 48-57 7538755-2 1995 Incubation of vascular smooth muscle cells with IL-1 beta resulted in the release of nitrite and in the intracellular accumulation of L-citrulline. Citrulline 134-146 interleukin 1 beta Rattus norvegicus 48-57 7538755-4 1995 Ethanol (6.5-650 mM) potentiated the IL-1 beta-mediated stimulation of iNOS mRNA production, the appearance of iNOS protein and the generation of nitrite and L-citrulline from smooth muscle cells in a concentration-dependent manner. Ethanol 0-7 interleukin 1 beta Rattus norvegicus 37-46 7538755-4 1995 Ethanol (6.5-650 mM) potentiated the IL-1 beta-mediated stimulation of iNOS mRNA production, the appearance of iNOS protein and the generation of nitrite and L-citrulline from smooth muscle cells in a concentration-dependent manner. Nitrites 146-153 interleukin 1 beta Rattus norvegicus 37-46 7538755-4 1995 Ethanol (6.5-650 mM) potentiated the IL-1 beta-mediated stimulation of iNOS mRNA production, the appearance of iNOS protein and the generation of nitrite and L-citrulline from smooth muscle cells in a concentration-dependent manner. Citrulline 158-170 interleukin 1 beta Rattus norvegicus 37-46 7538755-6 1995 These results demonstrate that pharmacologically relevant concentrations of ethanol enhance the IL-1 beta-induced expression of the iNOS gene in vascular smooth muscle. Ethanol 76-83 interleukin 1 beta Rattus norvegicus 96-105 7720637-0 1995 Long-term effects of nicotinamide-induced inhibition of poly(adenosine diphosphate-ribose) polymerase activity in rat pancreatic islets exposed to interleukin-1 beta. Niacinamide 21-33 interleukin 1 beta Rattus norvegicus 147-165 7720637-2 1995 This study aimed to examine the consequence of exposing isolated rat pancreatic islets to various concentrations of NIC (0, 0.5, 1.0, 5.0, 10, and 25 mM) over a prolonged period (6 days) in tissue culture and also to assess the efficacy of NIC to counteract interleukin-1 beta (IL-1; 25 U/ml)-induced beta-cell dysfunction. Niacinamide 116-119 interleukin 1 beta Rattus norvegicus 258-276 7570112-1 1995 Insulin release from pancreatic islet cells of neonatal rats could be markedly inhibited by a previous incubation of cells with interleukin-1 beta (5-20 U/ml) for 20 h even under high glucose (20 mmol/L) stimulation. Glucose 184-191 interleukin 1 beta Rattus norvegicus 128-146 7570112-2 1995 This inhibitory effect of IL-1 beta on insulin release could be reversed by testosterone (10(-10) mol/L), which was accompanied by an increase of the insulin content in islet cells. Testosterone 76-88 interleukin 1 beta Rattus norvegicus 26-35 7722482-4 1995 This stimulatory action of phorbol 12-myristate 13-acetate was significantly reduced by staurosporine, by calphostin C and by the desensitization of protein kinase C. Interleukin 1 beta increased interleukin 6 release in a concentration-related manner. Tetradecanoylphorbol Acetate 27-58 interleukin 1 beta Rattus norvegicus 167-185 7722482-4 1995 This stimulatory action of phorbol 12-myristate 13-acetate was significantly reduced by staurosporine, by calphostin C and by the desensitization of protein kinase C. Interleukin 1 beta increased interleukin 6 release in a concentration-related manner. Staurosporine 88-101 interleukin 1 beta Rattus norvegicus 167-185 7722482-4 1995 This stimulatory action of phorbol 12-myristate 13-acetate was significantly reduced by staurosporine, by calphostin C and by the desensitization of protein kinase C. Interleukin 1 beta increased interleukin 6 release in a concentration-related manner. calphostin C 106-118 interleukin 1 beta Rattus norvegicus 167-185 7722482-6 1995 The treatment of cortical astrocytes with both interleukin 1 beta (3 ng/ml) and phorbol 12-myristate 13-acetate (10 nM) caused a synergistic stimulation of interleukin 6 release and its gene expression, an effect that was not relieved by either 20 nM staurospine or by calphostin C but was slightly affected by protein kinase C desensitization. staurospine 251-262 interleukin 1 beta Rattus norvegicus 47-65 7722482-6 1995 The treatment of cortical astrocytes with both interleukin 1 beta (3 ng/ml) and phorbol 12-myristate 13-acetate (10 nM) caused a synergistic stimulation of interleukin 6 release and its gene expression, an effect that was not relieved by either 20 nM staurospine or by calphostin C but was slightly affected by protein kinase C desensitization. calphostin C 269-281 interleukin 1 beta Rattus norvegicus 47-65 7637265-3 1995 In the present experiments IL-1 beta increased COX II mRNA, and this was inhibited by genistein and herbimycin A, both inhibitors of protein tyrosine kinases. Genistein 86-95 interleukin 1 beta Rattus norvegicus 27-36 7637265-5 1995 Induction of COX II by interleukin-1 beta was mimicked by incubating the cells in the presence of a protein tyrosine phosphatase inhibitor, vanadate. Vanadates 140-148 interleukin 1 beta Rattus norvegicus 23-41 7640349-2 1995 In the rat prolonged exposure in vitro of islets of IL-1 beta leads to nitric oxide formation, impaired glucose metabolism and inhibition of insulin secretion. Nitric Oxide 71-83 interleukin 1 beta Rattus norvegicus 52-61 7610137-3 1995 LPS- and IL-1 beta-treated rats ate less, but ingested relatively more carbohydrate and less protein whereas relative fat intake remained unchanged. Carbohydrates 71-83 interleukin 1 beta Rattus norvegicus 9-18 7640349-8 1995 The medium nitrite accumulation, as an index of nitric oxide formation, was not influenced by IL-4 (10 ng/ml) alone, whilst IL-1 beta stimulation of medium nitrite was partly reduced by IL-4. Nitrites 156-163 interleukin 1 beta Rattus norvegicus 124-133 7698507-9 1995 Addition of nicotinamide and L-arginine depletion reduced the upregulation of 16 and 20 IL-1 beta-induced proteins, respectively. Niacinamide 12-24 interleukin 1 beta Rattus norvegicus 88-97 7698507-1 1995 Interleukin 1 beta-induced changes in protein expression are reduced by L-arginine depletion and nicotinamide. Arginine 72-82 interleukin 1 beta Rattus norvegicus 0-18 7698507-9 1995 Addition of nicotinamide and L-arginine depletion reduced the upregulation of 16 and 20 IL-1 beta-induced proteins, respectively. Arginine 29-39 interleukin 1 beta Rattus norvegicus 88-97 7698507-1 1995 Interleukin 1 beta-induced changes in protein expression are reduced by L-arginine depletion and nicotinamide. Niacinamide 97-109 interleukin 1 beta Rattus norvegicus 0-18 7698507-3 1995 Further, IL-1 beta-induced and tumor necrosis factor alpha-induced islet damage partly depends on the intracellular production of the nitric oxide (NO) radical. Nitric Oxide 134-146 interleukin 1 beta Rattus norvegicus 9-18 7698507-5 1995 Nicotinamide, while in itself inactive, inhibited IL-1 beta-induced NO production in a time- and dose-dependent manner. Niacinamide 0-12 interleukin 1 beta Rattus norvegicus 50-59 7711886-0 1995 Biphasic effect of interleukin-1 beta on arginine vasopressin-induced cellular cyclic adenosine monophosphate production in cultured rat renal papillary collecting tubule cells. Cyclic AMP 79-109 interleukin 1 beta Rattus norvegicus 19-37 7711886-1 1995 The present study was undertaken to determine whether interleukin (IL)-1 beta affects the response of cellular cyclic adenosine monophosphate production to arginine vasopressin (AVP) in cultured rat renal papillary collecting tubule cells. Cyclic AMP 111-141 interleukin 1 beta Rattus norvegicus 54-77 7711886-3 1995 A 10-min exposure of cells to IL-1 beta at a concentration of 1 x 10(-12) mol/l or higher significantly reduced the AVP-induced increases in cellular cAMP production but did not affect the 2 x 10(-8) mol/l forskolin-induced increases in cellular cAMP production. Cyclic AMP 150-154 interleukin 1 beta Rattus norvegicus 30-39 7711886-3 1995 A 10-min exposure of cells to IL-1 beta at a concentration of 1 x 10(-12) mol/l or higher significantly reduced the AVP-induced increases in cellular cAMP production but did not affect the 2 x 10(-8) mol/l forskolin-induced increases in cellular cAMP production. Colforsin 206-215 interleukin 1 beta Rattus norvegicus 30-39 7711886-3 1995 A 10-min exposure of cells to IL-1 beta at a concentration of 1 x 10(-12) mol/l or higher significantly reduced the AVP-induced increases in cellular cAMP production but did not affect the 2 x 10(-8) mol/l forskolin-induced increases in cellular cAMP production. Cyclic AMP 246-250 interleukin 1 beta Rattus norvegicus 30-39 7711886-4 1995 The IL-1 beta inhibition disappeared totally when cells were pretreated with 100 micrograms/l pertussis toxin for 2 h. In contrast, more than a 30-min exposure of cells to IL-1 beta increased basal cAMP levels and enhanced both the AVP-and forskolin-induced increases in cellular cAMP production. Cyclic AMP 198-202 interleukin 1 beta Rattus norvegicus 4-13 7711886-4 1995 The IL-1 beta inhibition disappeared totally when cells were pretreated with 100 micrograms/l pertussis toxin for 2 h. In contrast, more than a 30-min exposure of cells to IL-1 beta increased basal cAMP levels and enhanced both the AVP-and forskolin-induced increases in cellular cAMP production. Cyclic AMP 198-202 interleukin 1 beta Rattus norvegicus 172-181 7711886-4 1995 The IL-1 beta inhibition disappeared totally when cells were pretreated with 100 micrograms/l pertussis toxin for 2 h. In contrast, more than a 30-min exposure of cells to IL-1 beta increased basal cAMP levels and enhanced both the AVP-and forskolin-induced increases in cellular cAMP production. Colforsin 240-249 interleukin 1 beta Rattus norvegicus 4-13 7711886-4 1995 The IL-1 beta inhibition disappeared totally when cells were pretreated with 100 micrograms/l pertussis toxin for 2 h. In contrast, more than a 30-min exposure of cells to IL-1 beta increased basal cAMP levels and enhanced both the AVP-and forskolin-induced increases in cellular cAMP production. Colforsin 240-249 interleukin 1 beta Rattus norvegicus 172-181 7711886-4 1995 The IL-1 beta inhibition disappeared totally when cells were pretreated with 100 micrograms/l pertussis toxin for 2 h. In contrast, more than a 30-min exposure of cells to IL-1 beta increased basal cAMP levels and enhanced both the AVP-and forskolin-induced increases in cellular cAMP production. Cyclic AMP 280-284 interleukin 1 beta Rattus norvegicus 4-13 7711886-4 1995 The IL-1 beta inhibition disappeared totally when cells were pretreated with 100 micrograms/l pertussis toxin for 2 h. In contrast, more than a 30-min exposure of cells to IL-1 beta increased basal cAMP levels and enhanced both the AVP-and forskolin-induced increases in cellular cAMP production. Cyclic AMP 280-284 interleukin 1 beta Rattus norvegicus 172-181 7711886-5 1995 These results indicate that IL-1 beta produces biphasic regulation of AVP-induced cellular cAMP production in renal papillary collecting tubule cells. Cyclic AMP 91-95 interleukin 1 beta Rattus norvegicus 28-37 7711886-7 1995 However, the mechanism whereby the longer exposure to IL-1 beta enhances cAMP production remains to be determined. Cyclic AMP 73-77 interleukin 1 beta Rattus norvegicus 54-63 7627812-5 1995 Basal and TSH-induced I-5"-deiodination were significantly inhibited by 100 ng/liter of IL-1 beta and IL-6, and the inhibitory effect of TNF-alpha was seen over 1 microgram/liter. Thyrotropin 10-13 interleukin 1 beta Rattus norvegicus 88-97 7535802-0 1995 Amplification of nitric oxide synthase expression by nitric oxide in interleukin 1 beta-stimulated rat mesangial cells. nitric 17-23 interleukin 1 beta Rattus norvegicus 69-87 7535802-0 1995 Amplification of nitric oxide synthase expression by nitric oxide in interleukin 1 beta-stimulated rat mesangial cells. Nitric Oxide 17-29 interleukin 1 beta Rattus norvegicus 69-87 7535802-4 1995 NO donors such as sodium nitroprusside and S-nitroso-N-acetyl-D,L-penicillamine markedly increase IL-1 beta-induced NO synthase mRNA and protein levels as well as enzyme activity. Nitroprusside 18-38 interleukin 1 beta Rattus norvegicus 98-107 7535802-4 1995 NO donors such as sodium nitroprusside and S-nitroso-N-acetyl-D,L-penicillamine markedly increase IL-1 beta-induced NO synthase mRNA and protein levels as well as enzyme activity. snap 43-79 interleukin 1 beta Rattus norvegicus 98-107 7647767-0 1995 Effects of monoclonal antibodies to specific epitopes of rat interleukin-1 beta (IL-1 beta) on IL-1 beta-induced ACTH, corticosterone and IL-6 responses in rats. Corticosterone 119-133 interleukin 1 beta Rattus norvegicus 95-104 7535004-4 1995 Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production. Arginine 140-150 interleukin 1 beta Rattus norvegicus 31-49 7630433-0 1995 Inhibition by interleukin-1 beta of noradrenaline release in rat spleen: involvement of lymphocytes, NO and opioid receptors. Norepinephrine 36-49 interleukin 1 beta Rattus norvegicus 14-32 7630433-1 1995 Effects of indomethacin, N omega-nitro-L-arginine (NNA) and naloxone, and of pretreatment with cyclophosphamide (CY), on the interleukin (IL)-1 beta induced inhibition of exocytotic noradrenaline release were investigated in the isolated, vascularly perfused spleen of the rat. Nitroarginine 25-49 interleukin 1 beta Rattus norvegicus 125-148 7630433-1 1995 Effects of indomethacin, N omega-nitro-L-arginine (NNA) and naloxone, and of pretreatment with cyclophosphamide (CY), on the interleukin (IL)-1 beta induced inhibition of exocytotic noradrenaline release were investigated in the isolated, vascularly perfused spleen of the rat. Cyclophosphamide 95-111 interleukin 1 beta Rattus norvegicus 125-148 7630433-1 1995 Effects of indomethacin, N omega-nitro-L-arginine (NNA) and naloxone, and of pretreatment with cyclophosphamide (CY), on the interleukin (IL)-1 beta induced inhibition of exocytotic noradrenaline release were investigated in the isolated, vascularly perfused spleen of the rat. Cyclophosphamide 113-115 interleukin 1 beta Rattus norvegicus 125-148 7630433-1 1995 Effects of indomethacin, N omega-nitro-L-arginine (NNA) and naloxone, and of pretreatment with cyclophosphamide (CY), on the interleukin (IL)-1 beta induced inhibition of exocytotic noradrenaline release were investigated in the isolated, vascularly perfused spleen of the rat. Norepinephrine 182-195 interleukin 1 beta Rattus norvegicus 125-148 7630433-3 1995 Perfusion of the spleen with Tyrode"s solution containing IL-1 beta (100 pg/ml) for 90 min caused an inhibition of the stimulation-evoked noradrenaline overflow which persisted for at least 20 min after washout of the IL. Norepinephrine 138-151 interleukin 1 beta Rattus norvegicus 58-67 7630433-6 1995 The inhibition of evoked overflow by IL-1 beta was not affected by indomethacin but was reduced or even prevented in the presence of NNA or naloxone, or after lymphocyte depletion of spleens by CY. Indomethacin 67-79 interleukin 1 beta Rattus norvegicus 37-46 7630433-6 1995 The inhibition of evoked overflow by IL-1 beta was not affected by indomethacin but was reduced or even prevented in the presence of NNA or naloxone, or after lymphocyte depletion of spleens by CY. Nitroarginine 133-136 interleukin 1 beta Rattus norvegicus 37-46 7630433-6 1995 The inhibition of evoked overflow by IL-1 beta was not affected by indomethacin but was reduced or even prevented in the presence of NNA or naloxone, or after lymphocyte depletion of spleens by CY. Naloxone 140-148 interleukin 1 beta Rattus norvegicus 37-46 7695605-0 1995 Enhanced processing of APP induced by IL-1 beta can be reduced by indomethacin and nordihydroguaiaretic acid. Indomethacin 66-78 interleukin 1 beta Rattus norvegicus 38-47 7695605-0 1995 Enhanced processing of APP induced by IL-1 beta can be reduced by indomethacin and nordihydroguaiaretic acid. Masoprocol 83-108 interleukin 1 beta Rattus norvegicus 38-47 7695605-6 1995 Indomethacin and NDGA, reported inhibitors of the cyclooxygenase and lipoxygenase pathways, respectively, block these effects, suggesting the involvement of prostaglandins and leukotrienes in IL-1 beta mediated APP processing. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 192-201 7695605-6 1995 Indomethacin and NDGA, reported inhibitors of the cyclooxygenase and lipoxygenase pathways, respectively, block these effects, suggesting the involvement of prostaglandins and leukotrienes in IL-1 beta mediated APP processing. Masoprocol 17-21 interleukin 1 beta Rattus norvegicus 192-201 7695605-6 1995 Indomethacin and NDGA, reported inhibitors of the cyclooxygenase and lipoxygenase pathways, respectively, block these effects, suggesting the involvement of prostaglandins and leukotrienes in IL-1 beta mediated APP processing. Prostaglandins 157-171 interleukin 1 beta Rattus norvegicus 192-201 7695605-6 1995 Indomethacin and NDGA, reported inhibitors of the cyclooxygenase and lipoxygenase pathways, respectively, block these effects, suggesting the involvement of prostaglandins and leukotrienes in IL-1 beta mediated APP processing. Leukotrienes 176-188 interleukin 1 beta Rattus norvegicus 192-201 7535004-4 1995 Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production. Nitrites 209-216 interleukin 1 beta Rattus norvegicus 31-49 7535004-4 1995 Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production. Nitrites 209-216 interleukin 1 beta Rattus norvegicus 51-60 7535004-5 1995 Increasing the concentration of IL-1 beta and TNF-alpha caused a progressive elevation in nitrite production but did not further stimulate L-arginine uptake. Nitrites 90-97 interleukin 1 beta Rattus norvegicus 32-41 7535006-5 1995 In IL-1 beta- and IFN-gamma-pretreated CMEC, dexamethasone only minimally suppressed the rise in iNOS mRNA, protein abundance, or maximal iNOS enzyme activity in whole cell lysates but suppressed nitrite production by 60% in intact CMEC. Dexamethasone 45-58 interleukin 1 beta Rattus norvegicus 3-12 7891108-3 1995 It is interesting that IL-1 beta, a known mitogen for rat astrocytes, suppressed human fetal astrocyte proliferation as determined by [3H]thymidine incorporation, bromodeoxyuridine (BrdU) labeling, and cell counting. Tritium 135-137 interleukin 1 beta Rattus norvegicus 23-32 7891108-3 1995 It is interesting that IL-1 beta, a known mitogen for rat astrocytes, suppressed human fetal astrocyte proliferation as determined by [3H]thymidine incorporation, bromodeoxyuridine (BrdU) labeling, and cell counting. Thymidine 138-147 interleukin 1 beta Rattus norvegicus 23-32 7891108-3 1995 It is interesting that IL-1 beta, a known mitogen for rat astrocytes, suppressed human fetal astrocyte proliferation as determined by [3H]thymidine incorporation, bromodeoxyuridine (BrdU) labeling, and cell counting. Bromodeoxyuridine 163-180 interleukin 1 beta Rattus norvegicus 23-32 7891108-3 1995 It is interesting that IL-1 beta, a known mitogen for rat astrocytes, suppressed human fetal astrocyte proliferation as determined by [3H]thymidine incorporation, bromodeoxyuridine (BrdU) labeling, and cell counting. Bromodeoxyuridine 182-186 interleukin 1 beta Rattus norvegicus 23-32 7609880-2 1995 In the present study, interleukin-1 beta immunocytochemistry has been performed at the light and electron microscopic level to study the cellular and subcellular localization of interleukin-1 beta in the brains of rats given endotoxin or saline. Sodium Chloride 238-244 interleukin 1 beta Rattus norvegicus 178-196 7535004-4 1995 Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production. Arginine 140-150 interleukin 1 beta Rattus norvegicus 51-60 7535004-4 1995 Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production. Nitric Oxide 165-177 interleukin 1 beta Rattus norvegicus 31-49 7535004-4 1995 Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production. Nitric Oxide 165-177 interleukin 1 beta Rattus norvegicus 51-60 7774683-0 1995 Ouabain enhances nitric oxide synthesis in rat vascular smooth muscle cells induced by interleukin-1 beta. Nitric Oxide 17-29 interleukin 1 beta Rattus norvegicus 87-105 7709417-8 1995 In contrast, administration of anti-IL-1 beta and ZnPP into the left cerebral ventricle attenuated the postischemic increase of brain water content and decreased the size of brain infarction (83.5 +/- 2.0% and 79.9 +/- 2.0% in the dorsal and ventral parts of the caudate putamen, respectively, in rats treated with 10 micrograms anti-IL-1 beta; P < .01). zinc protoporphyrin 50-54 interleukin 1 beta Rattus norvegicus 334-343 7709417-8 1995 In contrast, administration of anti-IL-1 beta and ZnPP into the left cerebral ventricle attenuated the postischemic increase of brain water content and decreased the size of brain infarction (83.5 +/- 2.0% and 79.9 +/- 2.0% in the dorsal and ventral parts of the caudate putamen, respectively, in rats treated with 10 micrograms anti-IL-1 beta; P < .01). Water 134-139 interleukin 1 beta Rattus norvegicus 36-45 7709417-10 1995 CONCLUSIONS: Application of rhIL-1 beta augmented the increase of brain water content, and application of anti-IL-1 beta depressed the increase of water content. Water 72-77 interleukin 1 beta Rattus norvegicus 30-39 8521141-4 1995 The effect of bacterial lipopolysaccharides (2.0 mg/kg) on interleukin-1 beta mRNA was studied in the rat adrenal gland by in situ hybridization histochemistry using a synthetic oligonucleotide probe. bacterial lipopolysaccharides 14-43 interleukin 1 beta Rattus norvegicus 59-77 7774683-1 1995 Incubation of cultured rat vascular smooth muscle cells with interleukin-1 beta caused a significant increase in the production of nitrite, a stable metabolite of nitric oxide (NO), in time- and dose-dependent manners. Nitrites 131-138 interleukin 1 beta Rattus norvegicus 61-79 7774683-1 1995 Incubation of cultured rat vascular smooth muscle cells with interleukin-1 beta caused a significant increase in the production of nitrite, a stable metabolite of nitric oxide (NO), in time- and dose-dependent manners. Nitric Oxide 163-175 interleukin 1 beta Rattus norvegicus 61-79 7774683-2 1995 Addition of ouabain to the culture further enhanced interleukin-1 beta-induced nitrite production. Ouabain 12-19 interleukin 1 beta Rattus norvegicus 52-70 7774683-2 1995 Addition of ouabain to the culture further enhanced interleukin-1 beta-induced nitrite production. Nitrites 79-86 interleukin 1 beta Rattus norvegicus 52-70 7774683-3 1995 Similarly, interleukin-1 beta produced a significant increase in the cellular level of guanosine 3",5"-cyclic monophosphate, and the increase was significantly enhanced by coincubation with ouabain. Cyclic GMP 87-123 interleukin 1 beta Rattus norvegicus 11-29 7774683-4 1995 The calcium ionophore ionomycin also significantly enhanced interleukin-1 beta-induced nitrite generation. Calcium 4-11 interleukin 1 beta Rattus norvegicus 60-78 7774683-4 1995 The calcium ionophore ionomycin also significantly enhanced interleukin-1 beta-induced nitrite generation. Ionomycin 22-31 interleukin 1 beta Rattus norvegicus 60-78 7774683-4 1995 The calcium ionophore ionomycin also significantly enhanced interleukin-1 beta-induced nitrite generation. Nitrites 87-94 interleukin 1 beta Rattus norvegicus 60-78 7774683-5 1995 These findings indicate that ouabain enhances NO synthesis in vascular smooth muscle cells induced by interleukin-1 beta, presumably through an increase in intracellular calcium ion concentrations. Calcium 170-177 interleukin 1 beta Rattus norvegicus 102-120 7771651-7 1995 In contrast, E rats released as much corticosterone as C rats in response to IL-1 beta, but significantly (p < 0.05) more following administration of endotoxin (lipopolysaccharide). Corticosterone 37-51 interleukin 1 beta Rattus norvegicus 77-86 7768270-0 1995 Evidence for a role of nitric oxide in the corticotropin-releasing factor release induced by interleukin-1 beta. Nitric Oxide 23-35 interleukin 1 beta Rattus norvegicus 93-111 7768270-1 1995 Interleukin-1 beta stimulates corticotropin-releasing factor (CRF) secretion from the hypothalamus involving the activation of prostaglandins. Prostaglandins 127-141 interleukin 1 beta Rattus norvegicus 0-18 7864073-2 1995 When myocytes were internally dialyzed with a solution containing GTP, IL-1 beta caused a concentration-dependent decrease in the peak ICa,L (Ba2+ as the charge carrier). N-methyl-valyl-amiclenomycin 142-146 interleukin 1 beta Rattus norvegicus 71-80 7771651-0 1995 Altered ACTH and corticosterone responses to interleukin-1 beta in male rats exposed to an alcohol diet: possible role of vasopressin and testosterone. Corticosterone 17-31 interleukin 1 beta Rattus norvegicus 45-63 7771651-1 1995 We have previously shown that female rats exposed to an alcohol (ethanol, E) diet exhibited a blunted ACTH response to systemically administered interleukin-1 beta (IL-1 beta). Alcohols 56-63 interleukin 1 beta Rattus norvegicus 145-163 7771651-1 1995 We have previously shown that female rats exposed to an alcohol (ethanol, E) diet exhibited a blunted ACTH response to systemically administered interleukin-1 beta (IL-1 beta). Alcohols 56-63 interleukin 1 beta Rattus norvegicus 165-174 7771651-1 1995 We have previously shown that female rats exposed to an alcohol (ethanol, E) diet exhibited a blunted ACTH response to systemically administered interleukin-1 beta (IL-1 beta). Ethanol 65-72 interleukin 1 beta Rattus norvegicus 145-163 7771651-1 1995 We have previously shown that female rats exposed to an alcohol (ethanol, E) diet exhibited a blunted ACTH response to systemically administered interleukin-1 beta (IL-1 beta). Ethanol 65-72 interleukin 1 beta Rattus norvegicus 165-174 7856754-11 1995 These data suggest that locally produced TNF-alpha and IL-1 beta play regulatory roles in glucan-induced pulmonary granulomatous vasculitis through the modulation of local MCP-1 production. Glucans 90-96 interleukin 1 beta Rattus norvegicus 55-64 7864073-5 1995 In contrast, when guanosine 5"-O-(3-thiotriphosphate) was used to replace GTP, the suppression of ICa,L induced by IL-1 beta remained. Guanosine 5'-O-(3-Thiotriphosphate) 18-52 interleukin 1 beta Rattus norvegicus 115-124 7864073-5 1995 In contrast, when guanosine 5"-O-(3-thiotriphosphate) was used to replace GTP, the suppression of ICa,L induced by IL-1 beta remained. Guanosine Triphosphate 74-77 interleukin 1 beta Rattus norvegicus 115-124 7864073-1 1995 The effect and possible signal transduction pathway of interleukin-1 beta (IL-1 beta) on the L-type Ca2+ current (ICa,L) in cultured adult rat ventricular myocytes were examined using whole cell patch-clamp techniques. isocyanic acid 114-117 interleukin 1 beta Rattus norvegicus 55-73 7864073-1 1995 The effect and possible signal transduction pathway of interleukin-1 beta (IL-1 beta) on the L-type Ca2+ current (ICa,L) in cultured adult rat ventricular myocytes were examined using whole cell patch-clamp techniques. isocyanic acid 114-117 interleukin 1 beta Rattus norvegicus 75-84 7864073-5 1995 In contrast, when guanosine 5"-O-(3-thiotriphosphate) was used to replace GTP, the suppression of ICa,L induced by IL-1 beta remained. isocyanic acid 98-101 interleukin 1 beta Rattus norvegicus 115-124 7864073-2 1995 When myocytes were internally dialyzed with a solution containing GTP, IL-1 beta caused a concentration-dependent decrease in the peak ICa,L (Ba2+ as the charge carrier). Guanosine Triphosphate 66-69 interleukin 1 beta Rattus norvegicus 71-80 7864073-7 1995 We conclude that in cultured rat ventricular myocytes, IL-1 beta suppresses ICa,L via a PTX-insensitive G protein. isocyanic acid 76-79 interleukin 1 beta Rattus norvegicus 55-64 7864073-2 1995 When myocytes were internally dialyzed with a solution containing GTP, IL-1 beta caused a concentration-dependent decrease in the peak ICa,L (Ba2+ as the charge carrier). isocyanic acid 135-138 interleukin 1 beta Rattus norvegicus 71-80 7668153-0 1995 Chronic treatment with morphine and ethanol, but not cocaine, attenuates IL-1 beta activation of FOS expression in the rat hypothalamic paraventricular nucleus. Morphine 23-31 interleukin 1 beta Rattus norvegicus 73-82 7588387-10 1995 Both IL-1 alpha and IL-1 beta significantly elevated (P < 0.05) epinephrine levels after a 24 hr incubation period compared to media-treated controls. Epinephrine 67-78 interleukin 1 beta Rattus norvegicus 20-29 7822803-11 1995 Moreover, the results reveal that this activity of IL-1 beta is receptor mediated and dependent on the induction of proteins that may be involved in the local generation of secondary inflammatory mediators including PAF and an IL-8-like molecule. Platelet Activating Factor 216-219 interleukin 1 beta Rattus norvegicus 51-60 7588387-5 1995 IL-1 alpha and IL-1 beta elevated corticosterone release after a 24 hr incubation period. Corticosterone 34-48 interleukin 1 beta Rattus norvegicus 15-24 7716222-0 1995 Ginsenoside Rg1 modulates ingestive behavior and thermal response induced by interleukin-1 beta in rats. Ginsenosides 0-11 interleukin 1 beta Rattus norvegicus 77-95 7716222-2 1995 Intraperitoneal (ip) injection of IL-1 beta suppressed food and water intake and elevated rectal temperature. Water 64-69 interleukin 1 beta Rattus norvegicus 34-43 7716222-3 1995 The suppressive effect of IL-1 beta on water intake was converted to an increase when 4.0 mM Rg1 was continuously infused into the third cerebroventricle (ICV) at a rate of 0.966 microliters/h. Water 39-44 interleukin 1 beta Rattus norvegicus 26-35 7716222-6 1995 These results suggest that sustained ICV infusion of Rg1 may modulate the effects of IL-1 beta on ingestive behaviors, i.e., increase in water intake and sustained decrease in food intake, resulting in a lowering of body temperature. Water 137-142 interleukin 1 beta Rattus norvegicus 85-94 7668153-0 1995 Chronic treatment with morphine and ethanol, but not cocaine, attenuates IL-1 beta activation of FOS expression in the rat hypothalamic paraventricular nucleus. Ethanol 36-43 interleukin 1 beta Rattus norvegicus 73-82 7668153-5 1995 In this study, we compared the effects of morphine, ethanol and cocaine on IL-1 beta induction of FOS-IR in the rat hypothalamus. Morphine 42-50 interleukin 1 beta Rattus norvegicus 75-84 7668153-5 1995 In this study, we compared the effects of morphine, ethanol and cocaine on IL-1 beta induction of FOS-IR in the rat hypothalamus. Ethanol 52-59 interleukin 1 beta Rattus norvegicus 75-84 7668153-5 1995 In this study, we compared the effects of morphine, ethanol and cocaine on IL-1 beta induction of FOS-IR in the rat hypothalamus. Cocaine 64-71 interleukin 1 beta Rattus norvegicus 75-84 7668153-8 1995 Chronic treatment with morphine desensitized FOS responsiveness to morphine and IL-1 beta in the PVN since FOS-IR was no longer induced by IL-1 beta or morphine in the PVN after this treatment. Morphine 23-31 interleukin 1 beta Rattus norvegicus 80-89 7668153-8 1995 Chronic treatment with morphine desensitized FOS responsiveness to morphine and IL-1 beta in the PVN since FOS-IR was no longer induced by IL-1 beta or morphine in the PVN after this treatment. Morphine 23-31 interleukin 1 beta Rattus norvegicus 139-148 7668153-9 1995 Similarly, chronic ethanol treatment desensitized FOS responsiveness to ethanol and to IL-1 beta in the PVN. Ethanol 19-26 interleukin 1 beta Rattus norvegicus 87-96 7639621-8 1995 This L-arginine-derived autacoid, however, plays a role in the release of CGRP from afferent nerve fibres in the skin since it contributes to the CGRP-mediated vasodilator responses to chemical irritation or immunological challenge via interleukin-1 beta. Arginine 5-15 interleukin 1 beta Rattus norvegicus 236-254 21153236-9 1995 This study, shows that the earlier reported pro-ovulatory action of IL-1beta is not likely to be mediated by activation of the PA-system and suggests that IL-1beta may mediate a regulatory loop controlling the extent and distribution of LH-induced PA activity in rat preovulatory follicles. Luteinizing Hormone 237-239 interleukin 1 beta Rattus norvegicus 68-76 7744228-0 1995 Copper addition prevents the inhibitory effects of interleukin 1-beta on rat pancreatic islets. Copper 0-6 interleukin 1 beta Rattus norvegicus 51-69 7744228-1 1995 Since copper [Cu(II)] is a necessary cofactor for both intra-mitochondrial enzymes involved in energy production and hydroxyl scavenger enzymes, two hypothesised mechanisms for action of interleukin-I beta (IL-1 beta), we studied whether Cu(II) addition could prevent the inhibitory effect of IL-1 beta on insulin release and glucose oxidation in rat pancreatic islets. Copper 6-12 interleukin 1 beta Rattus norvegicus 207-216 7744228-1 1995 Since copper [Cu(II)] is a necessary cofactor for both intra-mitochondrial enzymes involved in energy production and hydroxyl scavenger enzymes, two hypothesised mechanisms for action of interleukin-I beta (IL-1 beta), we studied whether Cu(II) addition could prevent the inhibitory effect of IL-1 beta on insulin release and glucose oxidation in rat pancreatic islets. Copper 6-12 interleukin 1 beta Rattus norvegicus 293-302 7744228-1 1995 Since copper [Cu(II)] is a necessary cofactor for both intra-mitochondrial enzymes involved in energy production and hydroxyl scavenger enzymes, two hypothesised mechanisms for action of interleukin-I beta (IL-1 beta), we studied whether Cu(II) addition could prevent the inhibitory effect of IL-1 beta on insulin release and glucose oxidation in rat pancreatic islets. cu(ii) 14-20 interleukin 1 beta Rattus norvegicus 207-216 7744228-1 1995 Since copper [Cu(II)] is a necessary cofactor for both intra-mitochondrial enzymes involved in energy production and hydroxyl scavenger enzymes, two hypothesised mechanisms for action of interleukin-I beta (IL-1 beta), we studied whether Cu(II) addition could prevent the inhibitory effect of IL-1 beta on insulin release and glucose oxidation in rat pancreatic islets. cu(ii) 14-20 interleukin 1 beta Rattus norvegicus 293-302 7744228-1 1995 Since copper [Cu(II)] is a necessary cofactor for both intra-mitochondrial enzymes involved in energy production and hydroxyl scavenger enzymes, two hypothesised mechanisms for action of interleukin-I beta (IL-1 beta), we studied whether Cu(II) addition could prevent the inhibitory effect of IL-1 beta on insulin release and glucose oxidation in rat pancreatic islets. Hydroxyl Radical 117-125 interleukin 1 beta Rattus norvegicus 207-216 7744228-6 1995 In islets pre-exposed to 50 U/ml IL-1 beta, basal insulin release was not significantly affected but glucose-induced insulin release was greatly reduced (841.2 +/- 76.9, n = 7, p < 0.005). Glucose 101-108 interleukin 1 beta Rattus norvegicus 33-42 7744228-7 1995 In islets incubated with IL-1 beta and Cu-GHL (0.4 mumol/l, maximal effect) basal secretion was 119.0 +/- 13.1 pg.islet-1 h-1 and glucose-induced release was 2797.2 +/- 242.2, (n = 7, p < 0.01 in respect to islets exposed to IL-1 beta alone). Glucose 130-137 interleukin 1 beta Rattus norvegicus 25-34 8834771-3 1995 In this study, we examined the effects of heparin on the bone-resorbing activity of the inflammatory cytokine IL-1 beta. Heparin 42-49 interleukin 1 beta Rattus norvegicus 110-119 7536096-0 1995 The role of nitric oxide in cardiac depression induced by interleukin-1 beta and tumour necrosis factor-alpha. Nitric Oxide 12-24 interleukin 1 beta Rattus norvegicus 58-109 7536096-11 1995 The competitive inhibitor of Ca(2+)-dependent and Ca(2+)-independent NO synthases, NG-nitro-L-arginine methyl ester (L-NAME, 3 microM) when given concurrently with IL-1 beta plus TNF-alpha prevented the loss in contractile function such that these hearts after 2 h of perfusion had similar function to time-matched controls. NG-Nitroarginine Methyl Ester 83-115 interleukin 1 beta Rattus norvegicus 164-173 7536096-11 1995 The competitive inhibitor of Ca(2+)-dependent and Ca(2+)-independent NO synthases, NG-nitro-L-arginine methyl ester (L-NAME, 3 microM) when given concurrently with IL-1 beta plus TNF-alpha prevented the loss in contractile function such that these hearts after 2 h of perfusion had similar function to time-matched controls. NG-Nitroarginine Methyl Ester 117-123 interleukin 1 beta Rattus norvegicus 164-173 7536096-15 1995 Inhibition of protein synthesis with cycloheximide (Cx) abolished the loss in function that occurred over 2h in both control and IL-1 beta plus TNF-a-treated hearts.7. Cycloheximide 37-50 interleukin 1 beta Rattus norvegicus 129-138 7536096-15 1995 Inhibition of protein synthesis with cycloheximide (Cx) abolished the loss in function that occurred over 2h in both control and IL-1 beta plus TNF-a-treated hearts.7. Cycloheximide 52-54 interleukin 1 beta Rattus norvegicus 129-138 21153236-5 1995 LH and cytokine coincubations over 14h revealed that IL-1beta dosedependently inhibited the LH-induced increase in PA activity, up to 85%. Luteinizing Hormone 0-2 interleukin 1 beta Rattus norvegicus 53-61 21153236-7 1995 Both IL-1beta and TNFalpha increased P and PGE secretion time- and dose-dependently. Prostaglandins E 43-46 interleukin 1 beta Rattus norvegicus 5-13 21153236-8 1995 In summary, IL-1beta dose-dependently inhibits the LH-induced increase in PA activity in rat preovulatory folliclesin vitro while, as with TNFalpha, increasing P and PGE synthesis. Luteinizing Hormone 51-53 interleukin 1 beta Rattus norvegicus 12-20 21153236-8 1995 In summary, IL-1beta dose-dependently inhibits the LH-induced increase in PA activity in rat preovulatory folliclesin vitro while, as with TNFalpha, increasing P and PGE synthesis. Prostaglandins E 166-169 interleukin 1 beta Rattus norvegicus 12-20 21153236-9 1995 This study, shows that the earlier reported pro-ovulatory action of IL-1beta is not likely to be mediated by activation of the PA-system and suggests that IL-1beta may mediate a regulatory loop controlling the extent and distribution of LH-induced PA activity in rat preovulatory follicles. Luteinizing Hormone 237-239 interleukin 1 beta Rattus norvegicus 155-163 7805908-5 1995 Although treatment of whole ovarian dispersates with 10 ng/mL IL-1 beta resulted in a 5.4-fold increase in the accumulation of prostaglandin (PG)E2, this effect too was all but eliminated after the concomitant addition of 5 micrograms/mL IL-1ra. Dinoprostone 127-147 interleukin 1 beta Rattus norvegicus 62-71 8788310-8 1995 The plasma corticosterone concentration was higher in IL-1b-treated animals than in the control group, 107.79 +/- 2.82 vs. 61.08 +/- 2.0 ng/ml, respectively, p < 0.01. Corticosterone 11-25 interleukin 1 beta Rattus norvegicus 54-59 7805908-7 1995 Moreover, these observations suggest that the ability of IL-1 beta to inhibit the gonadotropin-supported accumulation of P and to increase PGE2 accumulation is receptor-mediated. Dinoprostone 139-143 interleukin 1 beta Rattus norvegicus 57-66 7564876-6 1995 This compound was effective on PGE2, LTB4, bradykinin, PAF or IL-1 beta-induced decrease in pain threshold in the rat paw pressure model and almost totally suppressed the writhing induced by zymosan in mice, while peritoneal production of 6-ketoPGF1 alpha was inhibited by 48.5-62% and only at 100 mg/kg significant inhibition of LTC4 was achieved. Dinoprostone 31-35 interleukin 1 beta Rattus norvegicus 62-71 7544862-2 1995 Similarly, interleukin-1 beta (IL-1 beta) triggered initiation of Arg-induced relaxation of the arteries. Arginine 66-69 interleukin 1 beta Rattus norvegicus 11-29 7564876-6 1995 This compound was effective on PGE2, LTB4, bradykinin, PAF or IL-1 beta-induced decrease in pain threshold in the rat paw pressure model and almost totally suppressed the writhing induced by zymosan in mice, while peritoneal production of 6-ketoPGF1 alpha was inhibited by 48.5-62% and only at 100 mg/kg significant inhibition of LTC4 was achieved. Zymosan 191-198 interleukin 1 beta Rattus norvegicus 62-71 7544862-2 1995 Similarly, interleukin-1 beta (IL-1 beta) triggered initiation of Arg-induced relaxation of the arteries. Arginine 66-69 interleukin 1 beta Rattus norvegicus 31-40 7544862-3 1995 In addition, in the aortic smooth muscle cells cultured in the presence of Arg, LPS- or IL-1 beta-triggered accumulation of nitrite was suppressed by the tyrosine kinase inhibitors. Arginine 75-78 interleukin 1 beta Rattus norvegicus 88-97 8808183-5 1995 The cytokine IL-1 beta caused a significant decrease in both beta-cell mitogenesis and insulin accumulation, effects that were mediated through nitric oxide generation. Nitric Oxide 144-156 interleukin 1 beta Rattus norvegicus 13-22 7544862-3 1995 In addition, in the aortic smooth muscle cells cultured in the presence of Arg, LPS- or IL-1 beta-triggered accumulation of nitrite was suppressed by the tyrosine kinase inhibitors. Nitrites 124-131 interleukin 1 beta Rattus norvegicus 88-97 7544862-4 1995 These results suggest that tyrosine kinase is involved in the LPS- and IL-1 beta-promoted induction of nitric oxide synthase in the vascular smooth muscle, which in turn mediates production of NO from added Arg, thus stimulating formation of cGMP and causing relaxation. Arginine 207-210 interleukin 1 beta Rattus norvegicus 71-80 7544862-4 1995 These results suggest that tyrosine kinase is involved in the LPS- and IL-1 beta-promoted induction of nitric oxide synthase in the vascular smooth muscle, which in turn mediates production of NO from added Arg, thus stimulating formation of cGMP and causing relaxation. Cyclic GMP 242-246 interleukin 1 beta Rattus norvegicus 71-80 7538649-0 1995 Interleukin-1 beta induces the formation of nitric oxide in isolated juxtaglomerular cells: influence on renin secretion. Nitric Oxide 44-56 interleukin 1 beta Rattus norvegicus 0-18 7538649-5 1995 Stimulation of JGC with IL-1 beta or SNP increased cGMP in the supernatant significantly. Cyclic GMP 51-55 interleukin 1 beta Rattus norvegicus 24-33 7528998-8 1994 IL-1 beta induced the expression of inducible NOS mRNA in vascular SMC, which was enhanced by coincubation of IL-1 beta with either CGRP, isoproterenol, or forskolin. Colforsin 156-165 interleukin 1 beta Rattus norvegicus 0-9 7538649-6 1995 The NO synthase inhibitors NG-nitro-L-arginine or NG-monomethyl-L-arginine, or the NO scavenger oxyhaemoglobin prevented the IL-1 beta-induced increase of cGMP. Nitroarginine 27-46 interleukin 1 beta Rattus norvegicus 125-134 7538649-6 1995 The NO synthase inhibitors NG-nitro-L-arginine or NG-monomethyl-L-arginine, or the NO scavenger oxyhaemoglobin prevented the IL-1 beta-induced increase of cGMP. omega-N-Methylarginine 50-74 interleukin 1 beta Rattus norvegicus 125-134 7538649-6 1995 The NO synthase inhibitors NG-nitro-L-arginine or NG-monomethyl-L-arginine, or the NO scavenger oxyhaemoglobin prevented the IL-1 beta-induced increase of cGMP. Cyclic GMP 155-159 interleukin 1 beta Rattus norvegicus 125-134 7538649-7 1995 The biological activity of NO was shown in a bioassay by the vasodilatory effect of the effluent from an IL-1 beta-stimulated JGC column on a precontracted rat aortic ring and was prevented by oxyhaemoglobin and methylene blue. Methylene Blue 212-226 interleukin 1 beta Rattus norvegicus 105-114 7527554-1 1994 The inflammatory cytokine interleukin 1 beta (IL-1 beta) induces both cyclooxygenase (COX) and nitric oxide synthase (NOS) with increases in the release of prostaglandin (PG) and nitric oxide (NO) by mesangial cells. Prostaglandins 156-169 interleukin 1 beta Rattus norvegicus 26-44 7527554-1 1994 The inflammatory cytokine interleukin 1 beta (IL-1 beta) induces both cyclooxygenase (COX) and nitric oxide synthase (NOS) with increases in the release of prostaglandin (PG) and nitric oxide (NO) by mesangial cells. Prostaglandins 156-169 interleukin 1 beta Rattus norvegicus 46-55 7527554-1 1994 The inflammatory cytokine interleukin 1 beta (IL-1 beta) induces both cyclooxygenase (COX) and nitric oxide synthase (NOS) with increases in the release of prostaglandin (PG) and nitric oxide (NO) by mesangial cells. Prostaglandins 171-173 interleukin 1 beta Rattus norvegicus 26-44 7527554-1 1994 The inflammatory cytokine interleukin 1 beta (IL-1 beta) induces both cyclooxygenase (COX) and nitric oxide synthase (NOS) with increases in the release of prostaglandin (PG) and nitric oxide (NO) by mesangial cells. Prostaglandins 171-173 interleukin 1 beta Rattus norvegicus 46-55 7527554-1 1994 The inflammatory cytokine interleukin 1 beta (IL-1 beta) induces both cyclooxygenase (COX) and nitric oxide synthase (NOS) with increases in the release of prostaglandin (PG) and nitric oxide (NO) by mesangial cells. Nitric Oxide 95-107 interleukin 1 beta Rattus norvegicus 26-44 7527554-1 1994 The inflammatory cytokine interleukin 1 beta (IL-1 beta) induces both cyclooxygenase (COX) and nitric oxide synthase (NOS) with increases in the release of prostaglandin (PG) and nitric oxide (NO) by mesangial cells. Nitric Oxide 95-107 interleukin 1 beta Rattus norvegicus 46-55 7527554-5 1994 A COX inhibitor, indomethacin, enhanced IL-1 beta-induced steady-state level of the inducible NOS (iNOS) mRNA and nitrite production. Indomethacin 17-29 interleukin 1 beta Rattus norvegicus 40-49 7527554-5 1994 A COX inhibitor, indomethacin, enhanced IL-1 beta-induced steady-state level of the inducible NOS (iNOS) mRNA and nitrite production. Nitrites 114-121 interleukin 1 beta Rattus norvegicus 40-49 7527554-7 1994 In contrast to PGE2, a stable analog of PGI2, carba prostacyclin, enhanced IL-1 beta-induced iNOS mRNA levels and nitrite production. Epoprostenol 40-44 interleukin 1 beta Rattus norvegicus 75-84 7527554-7 1994 In contrast to PGE2, a stable analog of PGI2, carba prostacyclin, enhanced IL-1 beta-induced iNOS mRNA levels and nitrite production. carboprostacyclin 46-64 interleukin 1 beta Rattus norvegicus 75-84 7527554-7 1994 In contrast to PGE2, a stable analog of PGI2, carba prostacyclin, enhanced IL-1 beta-induced iNOS mRNA levels and nitrite production. Nitrites 114-121 interleukin 1 beta Rattus norvegicus 75-84 7528993-2 1994 Among several cytokines and bacterial lipopolysaccharide tested, IL-1 beta most effectively stimulated NOx production. nicotine 1-N-oxide 103-106 interleukin 1 beta Rattus norvegicus 65-74 7528993-3 1994 IL-1 beta dose and time dependently stimulated NOx production. nicotine 1-N-oxide 47-50 interleukin 1 beta Rattus norvegicus 0-9 7528993-5 1994 Transforming growth factor (TGF)-beta and dexamethasone blocked the IL-1 beta-induced NOx production as well as expression of iNOS mRNA and protein. Dexamethasone 42-55 interleukin 1 beta Rattus norvegicus 68-77 7528993-5 1994 Transforming growth factor (TGF)-beta and dexamethasone blocked the IL-1 beta-induced NOx production as well as expression of iNOS mRNA and protein. nicotine 1-N-oxide 86-89 interleukin 1 beta Rattus norvegicus 68-77 7528993-6 1994 TGF-beta dose dependently inhibited the IL-1 beta-induced NOx production and iNOS mRNA expression. nicotine 1-N-oxide 58-61 interleukin 1 beta Rattus norvegicus 40-49 7528998-2 1994 CGRP, in a concentration-dependent manner, enhanced the release of nitrite (a stable oxidation product of NO) and the formation of L-citrulline from L-arginine caused by IL-1 beta. Citrulline 131-143 interleukin 1 beta Rattus norvegicus 170-179 7528998-2 1994 CGRP, in a concentration-dependent manner, enhanced the release of nitrite (a stable oxidation product of NO) and the formation of L-citrulline from L-arginine caused by IL-1 beta. Arginine 149-159 interleukin 1 beta Rattus norvegicus 170-179 7528998-3 1994 Two cAMP-dependent vasodilators, forskolin and isoproterenol, and the activator of the cAMP-dependent protein kinase, Sp-cAMPS, also enhanced the release of nitrite and the formation of L-citrulline evoked by IL-1 beta. Cyclic AMP 4-8 interleukin 1 beta Rattus norvegicus 209-218 7528998-3 1994 Two cAMP-dependent vasodilators, forskolin and isoproterenol, and the activator of the cAMP-dependent protein kinase, Sp-cAMPS, also enhanced the release of nitrite and the formation of L-citrulline evoked by IL-1 beta. adenosine-3',5'-cyclic phosphorothioate 118-126 interleukin 1 beta Rattus norvegicus 209-218 7528998-3 1994 Two cAMP-dependent vasodilators, forskolin and isoproterenol, and the activator of the cAMP-dependent protein kinase, Sp-cAMPS, also enhanced the release of nitrite and the formation of L-citrulline evoked by IL-1 beta. Nitrites 157-164 interleukin 1 beta Rattus norvegicus 209-218 7528998-3 1994 Two cAMP-dependent vasodilators, forskolin and isoproterenol, and the activator of the cAMP-dependent protein kinase, Sp-cAMPS, also enhanced the release of nitrite and the formation of L-citrulline evoked by IL-1 beta. Citrulline 186-198 interleukin 1 beta Rattus norvegicus 209-218 7528998-5 1994 IL-1 beta-treated vascular SMC inhibited the aggregation of indomethacin-treated platelets. Indomethacin 60-72 interleukin 1 beta Rattus norvegicus 0-9 7810664-0 1994 Interleukin-1 beta inhibits gastric histamine secretion and synthesis in the rat. Histamine 36-45 interleukin 1 beta Rattus norvegicus 0-18 7810664-2 1994 Although histamine has been shown to be an important mediator of gastric acid secretion, the effect of IL-1 beta on gastric histamine mobilization has not been studied. Histamine 124-133 interleukin 1 beta Rattus norvegicus 103-112 7810664-6 1994 IL-1 beta (5 micrograms/kg iv) completely inhibited gastrin-induced acid secretion and partially inhibited urinary histamine excretion and fundic HDC activity. Histamine 115-124 interleukin 1 beta Rattus norvegicus 0-9 7810664-7 1994 Pretreatment with indomethacin (10 mg/kg ip) partially reversed the inhibitory effects of IL-1 beta on gastrin-stimulated fundic HDC activity and acid secretion. Indomethacin 18-30 interleukin 1 beta Rattus norvegicus 90-99 7810664-8 1994 These findings indicate that IL-1 beta inhibits gastric histamine mobilization through both prostaglandin-dependent and prostaglandin-independent pathways. Histamine 56-65 interleukin 1 beta Rattus norvegicus 29-38 7810664-8 1994 These findings indicate that IL-1 beta inhibits gastric histamine mobilization through both prostaglandin-dependent and prostaglandin-independent pathways. Prostaglandins 92-105 interleukin 1 beta Rattus norvegicus 29-38 7810664-8 1994 These findings indicate that IL-1 beta inhibits gastric histamine mobilization through both prostaglandin-dependent and prostaglandin-independent pathways. Prostaglandins 120-133 interleukin 1 beta Rattus norvegicus 29-38 7810664-9 1994 Furthermore, it is suggested that the inhibitory action of IL-1 beta on gastric acid secretion is mediated by the inhibition of gastric histamine mobilization. Histamine 136-145 interleukin 1 beta Rattus norvegicus 59-68 7528998-8 1994 IL-1 beta induced the expression of inducible NOS mRNA in vascular SMC, which was enhanced by coincubation of IL-1 beta with either CGRP, isoproterenol, or forskolin. Isoproterenol 138-151 interleukin 1 beta Rattus norvegicus 0-9 7528998-8 1994 IL-1 beta induced the expression of inducible NOS mRNA in vascular SMC, which was enhanced by coincubation of IL-1 beta with either CGRP, isoproterenol, or forskolin. Isoproterenol 138-151 interleukin 1 beta Rattus norvegicus 110-119 7528998-8 1994 IL-1 beta induced the expression of inducible NOS mRNA in vascular SMC, which was enhanced by coincubation of IL-1 beta with either CGRP, isoproterenol, or forskolin. Colforsin 156-165 interleukin 1 beta Rattus norvegicus 110-119 7528998-9 1994 These observations indicate that CGRP via a cAMP-dependent mechanism potentiates the IL-1-beta-induced production of NO by enhancing the expression of inducible NOS. Cyclic AMP 44-48 interleukin 1 beta Rattus norvegicus 85-94 7756973-5 1994 A key factor in the inhibitory effect of IL-1 beta and TNF in rat islets is the generation of nitric oxide which inactivates enzymes such as aconitase and ribonucleotide reductase by formation of iron-nitrosyl complexes. Nitric Oxide 94-106 interleukin 1 beta Rattus norvegicus 41-50 7534188-2 1994 These studies examine the effect of retinoids on interleukin 1 beta (IL-1 beta)-induced nitric oxide synthase (NOS) activity in cultured rat aortic vascular smooth muscle (VSM) cells and isolated rat aortic rings. Retinoids 36-45 interleukin 1 beta Rattus norvegicus 49-67 7534188-2 1994 These studies examine the effect of retinoids on interleukin 1 beta (IL-1 beta)-induced nitric oxide synthase (NOS) activity in cultured rat aortic vascular smooth muscle (VSM) cells and isolated rat aortic rings. Retinoids 36-45 interleukin 1 beta Rattus norvegicus 69-78 7534188-4 1994 All-trans-retinoic acid (all-trans-RA, 0.1-10 microM) and its active analogues produced concentration-dependent inhibition of IL-1 beta (0.1-10 ng ml-1)-induced nitrite production in cultured VSM cells. Tretinoin 0-23 interleukin 1 beta Rattus norvegicus 126-135 7534188-4 1994 All-trans-retinoic acid (all-trans-RA, 0.1-10 microM) and its active analogues produced concentration-dependent inhibition of IL-1 beta (0.1-10 ng ml-1)-induced nitrite production in cultured VSM cells. Tretinoin 25-37 interleukin 1 beta Rattus norvegicus 126-135 7534188-4 1994 All-trans-retinoic acid (all-trans-RA, 0.1-10 microM) and its active analogues produced concentration-dependent inhibition of IL-1 beta (0.1-10 ng ml-1)-induced nitrite production in cultured VSM cells. Nitrites 161-168 interleukin 1 beta Rattus norvegicus 126-135 7534188-8 1994 TGF-beta produced concentration-dependent (0.1-10 ng ml-1) inhibition of IL-1 beta-induced nitrite production and the maximum effect (approximately 90% inhibition) was significantly greater than that seen with all-trans-RA (approximately 70% with 10 microM). Nitrites 91-98 interleukin 1 beta Rattus norvegicus 73-82 7534188-11 1994 In addition to inhibiting IL-1 beta-induced nitrite production, all-trans-RA (10 microM) reduced substantially inducible NOS mRNA and protein levels in IL-1 beta-induced VSM cells (P < 0.01). Nitrites 44-51 interleukin 1 beta Rattus norvegicus 26-35 7534188-13 1994 Incubation of isolated rat aortic rings with IL-1 beta (10 ng ml-1) caused a progressive resistance of the rings to the vasoconstrictor action of phenylephrine (10 nM to 10 microM). Phenylephrine 146-159 interleukin 1 beta Rattus norvegicus 45-54 7988414-4 1994 The stimulation of CRH by interleukin-1 beta (100 ng/ml) was also significantly antagonized by hemin (1 microM). Hemin 95-100 interleukin 1 beta Rattus norvegicus 26-44 7756973-5 1994 A key factor in the inhibitory effect of IL-1 beta and TNF in rat islets is the generation of nitric oxide which inactivates enzymes such as aconitase and ribonucleotide reductase by formation of iron-nitrosyl complexes. Iron 196-200 interleukin 1 beta Rattus norvegicus 41-50 7533726-1 1994 Exposure of rat aortic rings without endothelium to interleukin-1 beta for 5 h significantly attenuated the contractions due to phenylephrine and increased the tissue content of guanosine 3",5"-cyclic monophosphate (cyclic GMP) due to the induction of nitric oxide synthase. Phenylephrine 128-141 interleukin 1 beta Rattus norvegicus 52-70 7534708-3 1994 Incubation of the culture with interleukin-1 beta (10 ng/ml) for 24 h caused a significant increase in nitrite levels. Nitrites 103-110 interleukin 1 beta Rattus norvegicus 31-49 7534708-4 1994 The basal and interleukin-1 beta-induced nitrite production by vascular smooth muscle cells were not affected by the presence of angiotensin converting enzyme inhibitors (0.1 approximately 10 microM), enalaprilat, cilazaprilat or captopril. Nitrites 41-48 interleukin 1 beta Rattus norvegicus 14-32 7980594-1 1994 In cultured rat aortic smooth muscle cells (RASMCs) IL-1 beta induced TGF-beta 1 mRNA expression, which was concentration (10 pM-10 nM)- and time (2-48 h) -dependent, and sensitive to cycloheximide. Cycloheximide 184-197 interleukin 1 beta Rattus norvegicus 52-61 7980594-3 1994 A parallel increase in TGF-beta 1 protein in the culture medium of IL-1 beta-stimulated RASMCs was also observed. rasmcs 88-94 interleukin 1 beta Rattus norvegicus 67-76 7961954-6 1994 Serotonin removal decreases IL-1 alpha and IL-1 beta mRNAs, and effect that is rapidly reversed upon readdition of serotonin. Serotonin 0-9 interleukin 1 beta Rattus norvegicus 43-52 7533726-1 1994 Exposure of rat aortic rings without endothelium to interleukin-1 beta for 5 h significantly attenuated the contractions due to phenylephrine and increased the tissue content of guanosine 3",5"-cyclic monophosphate (cyclic GMP) due to the induction of nitric oxide synthase. Cyclic GMP 178-214 interleukin 1 beta Rattus norvegicus 52-70 7533726-1 1994 Exposure of rat aortic rings without endothelium to interleukin-1 beta for 5 h significantly attenuated the contractions due to phenylephrine and increased the tissue content of guanosine 3",5"-cyclic monophosphate (cyclic GMP) due to the induction of nitric oxide synthase. Cyclic GMP 216-226 interleukin 1 beta Rattus norvegicus 52-70 7533726-2 1994 The presence of pyrrolidine dithiocarbamate, a specific inhibitor of nuclear transcription factor kappa B activation, during the exposure of the rings to interleukin-1 beta prevented these responses to interleukin-1 beta. pyrrolidine dithiocarbamic acid 16-43 interleukin 1 beta Rattus norvegicus 154-172 7533726-2 1994 The presence of pyrrolidine dithiocarbamate, a specific inhibitor of nuclear transcription factor kappa B activation, during the exposure of the rings to interleukin-1 beta prevented these responses to interleukin-1 beta. pyrrolidine dithiocarbamic acid 16-43 interleukin 1 beta Rattus norvegicus 202-220 7533726-3 1994 Rat aortic rings which had been incubated for 5 h with interleukin-1 beta in the absence and presence of pyrrolidine dithiocarbamate prior to the organ chamber experiment had a similar concentration-dependent relaxation curve for acetylcholine in rings with endothelium, and for 3-morpholino-sydnonimine (SIN-1) in rings without. Acetylcholine 230-243 interleukin 1 beta Rattus norvegicus 55-73 7533726-3 1994 Rat aortic rings which had been incubated for 5 h with interleukin-1 beta in the absence and presence of pyrrolidine dithiocarbamate prior to the organ chamber experiment had a similar concentration-dependent relaxation curve for acetylcholine in rings with endothelium, and for 3-morpholino-sydnonimine (SIN-1) in rings without. linsidomine 279-303 interleukin 1 beta Rattus norvegicus 55-73 7533726-3 1994 Rat aortic rings which had been incubated for 5 h with interleukin-1 beta in the absence and presence of pyrrolidine dithiocarbamate prior to the organ chamber experiment had a similar concentration-dependent relaxation curve for acetylcholine in rings with endothelium, and for 3-morpholino-sydnonimine (SIN-1) in rings without. Linsidomine 305-310 interleukin 1 beta Rattus norvegicus 55-73 7533726-5 1994 These observations suggest that pyrrolidine dithiocarbamate prevents the interleukin-1 beta-mediated expression of the inducible nitric oxide synthase without affecting the activity of the constitutive enzyme in the rat aorta. pyrrolidine dithiocarbamic acid 32-59 interleukin 1 beta Rattus norvegicus 73-91 7534893-0 1994 Interleukin-1 beta induces histamine release in the rat hypothalamus in vivo. Histamine 27-36 interleukin 1 beta Rattus norvegicus 0-18 7525557-5 1994 Using this 217-base pair cDNA as a probe in Northern blots, we found no evidence of iNOS mRNA in control myocytes, but both interleukin-1 beta and interferon-gamma individually increased iNOS mRNA abundance in primary cultures of ARVM, with maximal expression at 12 h. The half-life of iNOS mRNA in actinomycin C1-treated cells was 4 h. Both dexamethasone and transforming growth factor-beta attenuated the induction of iNOS mRNA abundance and enzyme activity by IL-1 beta and INF gamma. Dactinomycin 299-313 interleukin 1 beta Rattus norvegicus 124-142 7525557-5 1994 Using this 217-base pair cDNA as a probe in Northern blots, we found no evidence of iNOS mRNA in control myocytes, but both interleukin-1 beta and interferon-gamma individually increased iNOS mRNA abundance in primary cultures of ARVM, with maximal expression at 12 h. The half-life of iNOS mRNA in actinomycin C1-treated cells was 4 h. Both dexamethasone and transforming growth factor-beta attenuated the induction of iNOS mRNA abundance and enzyme activity by IL-1 beta and INF gamma. Dexamethasone 342-355 interleukin 1 beta Rattus norvegicus 124-142 7534893-2 1994 Therefore, we investigated the effects of IL-1 beta on brain histamine dynamics by directly injecting it into the tuberomammillary nucleus of the rat hypothalamus (TM) using an in vivo microdialysis method. Histamine 61-70 interleukin 1 beta Rattus norvegicus 42-51 7534893-4 1994 Histamine release in the anterior hypothalamic area in vivo was significantly augmented from 140 min to 360 min following injection of IL-1 beta at 10 ng dose. Histamine 0-9 interleukin 1 beta Rattus norvegicus 135-144 7534893-5 1994 These results suggest the possibility that interrelationship between histamine and IL-1 beta may modulate the acute phase reaction in the central nervous system. Histamine 69-78 interleukin 1 beta Rattus norvegicus 83-92 7534490-4 1994 Incubation of mesangial cells with IL-1 beta (10 ng/ml) for 24 h increased the accumulation of NO and guanosine 3",5"-cyclic monophosphate (cGMP). Cyclic GMP 102-138 interleukin 1 beta Rattus norvegicus 35-44 7977701-3 1994 The cytokine interleukin-1 beta (IL-1 beta) inhibited serum- and platelet-derived growth factor-stimulated [3H]thymidine incorporation into DNA in subcultured rat aortic SMC. Tritium 108-110 interleukin 1 beta Rattus norvegicus 13-31 7977701-3 1994 The cytokine interleukin-1 beta (IL-1 beta) inhibited serum- and platelet-derived growth factor-stimulated [3H]thymidine incorporation into DNA in subcultured rat aortic SMC. Tritium 108-110 interleukin 1 beta Rattus norvegicus 33-42 7977701-4 1994 Incubation with IL-1 beta for 24 h markedly increased cGMP levels but not adenosine 3",5"-cyclic monophosphate (cAMP) levels. Cyclic GMP 54-58 interleukin 1 beta Rattus norvegicus 16-25 7977701-5 1994 However, the IL-1 beta-induced increase in cGMP was correlated with an activation of the cAMP-dependent protein kinase (cAMP kinase) activity ratio. Cyclic GMP 43-47 interleukin 1 beta Rattus norvegicus 13-22 7977701-5 1994 However, the IL-1 beta-induced increase in cGMP was correlated with an activation of the cAMP-dependent protein kinase (cAMP kinase) activity ratio. Cyclic AMP 89-93 interleukin 1 beta Rattus norvegicus 13-22 7977701-8 1994 The inhibition of DNA synthesis by both IL-1 beta and SNAP was observed only when cGMP levels were elevated to high levels (10-fold or more). Cyclic GMP 82-86 interleukin 1 beta Rattus norvegicus 40-49 7977701-10 1994 Selective inhibition of cAMP kinase using (R)-p-bromoadenosine 3",5"-cyclic monophosphorothioate prevented the inhibition of proliferation by IL-1 beta. (r)-p-bromoadenosine 3",5"-cyclic monophosphorothioate 42-96 interleukin 1 beta Rattus norvegicus 142-151 7534490-4 1994 Incubation of mesangial cells with IL-1 beta (10 ng/ml) for 24 h increased the accumulation of NO and guanosine 3",5"-cyclic monophosphate (cGMP). Cyclic GMP 140-144 interleukin 1 beta Rattus norvegicus 35-44 7534490-8 1994 IL-1 beta-induced NO synthesis was significantly inhibited by NG-monomethyl-L-arginine, cycloheximide, actinomycin D, dexamethasone, and TGF-beta. omega-N-Methylarginine 62-86 interleukin 1 beta Rattus norvegicus 0-9 7534490-8 1994 IL-1 beta-induced NO synthesis was significantly inhibited by NG-monomethyl-L-arginine, cycloheximide, actinomycin D, dexamethasone, and TGF-beta. Cycloheximide 88-101 interleukin 1 beta Rattus norvegicus 0-9 7534490-8 1994 IL-1 beta-induced NO synthesis was significantly inhibited by NG-monomethyl-L-arginine, cycloheximide, actinomycin D, dexamethasone, and TGF-beta. Dactinomycin 103-116 interleukin 1 beta Rattus norvegicus 0-9 7534490-8 1994 IL-1 beta-induced NO synthesis was significantly inhibited by NG-monomethyl-L-arginine, cycloheximide, actinomycin D, dexamethasone, and TGF-beta. Dexamethasone 118-131 interleukin 1 beta Rattus norvegicus 0-9 7531790-3 1994 Inhibition of GTP-cyclohydrolase I, the rate-limiting enzyme for BH4 synthesis, with 2,4-diamino-6-hydroxy-pyrimidine (DAHP) potently suppresses IL-1 beta-induced nitrite production and elevation of cellular cGMP levels. sapropterin 65-68 interleukin 1 beta Rattus norvegicus 145-154 7523520-3 1994 hrIL-13 is found to be a potent in vitro modulator of various rat macrophage functions, including an inhibition of the production of the proinflammatory cytokines IL-1 beta and TNF, and a simultaneous enhancement of MHC class II and CD4 receptor expression. hril-13 0-7 interleukin 1 beta Rattus norvegicus 163-172 7531790-3 1994 Inhibition of GTP-cyclohydrolase I, the rate-limiting enzyme for BH4 synthesis, with 2,4-diamino-6-hydroxy-pyrimidine (DAHP) potently suppresses IL-1 beta-induced nitrite production and elevation of cellular cGMP levels. 2,4-diaminohypoxanthine 85-117 interleukin 1 beta Rattus norvegicus 145-154 7531790-0 1994 Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1 beta-stimulated rat glomerular mesangial cells. sapropterin 0-19 interleukin 1 beta Rattus norvegicus 71-89 7531790-0 1994 Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1 beta-stimulated rat glomerular mesangial cells. Nitric Oxide 44-56 interleukin 1 beta Rattus norvegicus 71-89 7531790-3 1994 Inhibition of GTP-cyclohydrolase I, the rate-limiting enzyme for BH4 synthesis, with 2,4-diamino-6-hydroxy-pyrimidine (DAHP) potently suppresses IL-1 beta-induced nitrite production and elevation of cellular cGMP levels. 2,4-diaminohypoxanthine 119-123 interleukin 1 beta Rattus norvegicus 145-154 7531790-3 1994 Inhibition of GTP-cyclohydrolase I, the rate-limiting enzyme for BH4 synthesis, with 2,4-diamino-6-hydroxy-pyrimidine (DAHP) potently suppresses IL-1 beta-induced nitrite production and elevation of cellular cGMP levels. Nitrites 163-170 interleukin 1 beta Rattus norvegicus 145-154 7531790-3 1994 Inhibition of GTP-cyclohydrolase I, the rate-limiting enzyme for BH4 synthesis, with 2,4-diamino-6-hydroxy-pyrimidine (DAHP) potently suppresses IL-1 beta-induced nitrite production and elevation of cellular cGMP levels. Cyclic GMP 208-212 interleukin 1 beta Rattus norvegicus 145-154 7531790-5 1994 Most importantly, sepiapterin dose-dependently augments IL-1 beta-stimulated NO synthesis, indicating that the availability of BH4 limits the production of NO in cytokine-induced mesangial cells. sepiapterin 18-29 interleukin 1 beta Rattus norvegicus 56-65 7531790-5 1994 Most importantly, sepiapterin dose-dependently augments IL-1 beta-stimulated NO synthesis, indicating that the availability of BH4 limits the production of NO in cytokine-induced mesangial cells. sapropterin 127-130 interleukin 1 beta Rattus norvegicus 56-65 7531790-6 1994 N-acetylserotonin, an inhibitor of the BH4 synthetic enzyme sepiapterin reductase, completely abolishes IL-1 beta-stimulated nitrite production, whereas methotrexate, which inhibits the pterin salvage pathway, displays only a moderate inhibitory effect, thus suggesting that mesangial cells predominantly synthesize BH4 by de novo synthesis from GTP. N-acetylserotonin 0-17 interleukin 1 beta Rattus norvegicus 104-113 7531790-6 1994 N-acetylserotonin, an inhibitor of the BH4 synthetic enzyme sepiapterin reductase, completely abolishes IL-1 beta-stimulated nitrite production, whereas methotrexate, which inhibits the pterin salvage pathway, displays only a moderate inhibitory effect, thus suggesting that mesangial cells predominantly synthesize BH4 by de novo synthesis from GTP. sapropterin 39-42 interleukin 1 beta Rattus norvegicus 104-113 7531790-6 1994 N-acetylserotonin, an inhibitor of the BH4 synthetic enzyme sepiapterin reductase, completely abolishes IL-1 beta-stimulated nitrite production, whereas methotrexate, which inhibits the pterin salvage pathway, displays only a moderate inhibitory effect, thus suggesting that mesangial cells predominantly synthesize BH4 by de novo synthesis from GTP. Nitrites 125-132 interleukin 1 beta Rattus norvegicus 104-113 7531790-6 1994 N-acetylserotonin, an inhibitor of the BH4 synthetic enzyme sepiapterin reductase, completely abolishes IL-1 beta-stimulated nitrite production, whereas methotrexate, which inhibits the pterin salvage pathway, displays only a moderate inhibitory effect, thus suggesting that mesangial cells predominantly synthesize BH4 by de novo synthesis from GTP. Pterins 65-71 interleukin 1 beta Rattus norvegicus 104-113 7531790-6 1994 N-acetylserotonin, an inhibitor of the BH4 synthetic enzyme sepiapterin reductase, completely abolishes IL-1 beta-stimulated nitrite production, whereas methotrexate, which inhibits the pterin salvage pathway, displays only a moderate inhibitory effect, thus suggesting that mesangial cells predominantly synthesize BH4 by de novo synthesis from GTP. sapropterin 316-319 interleukin 1 beta Rattus norvegicus 104-113 7531790-6 1994 N-acetylserotonin, an inhibitor of the BH4 synthetic enzyme sepiapterin reductase, completely abolishes IL-1 beta-stimulated nitrite production, whereas methotrexate, which inhibits the pterin salvage pathway, displays only a moderate inhibitory effect, thus suggesting that mesangial cells predominantly synthesize BH4 by de novo synthesis from GTP. Guanosine Triphosphate 346-349 interleukin 1 beta Rattus norvegicus 104-113 7531790-7 1994 In conclusion, these data demonstrate that BH4 synthesis is an absolute requirement for, and limits IL-1 beta induction of NO synthesis in mesangial cells. sapropterin 43-46 interleukin 1 beta Rattus norvegicus 100-109 7824567-0 1994 Reduction in food and water intake induced by microinjection of interleukin-1 beta in the ventromedial hypothalamus of the rat. Water 22-27 interleukin 1 beta Rattus norvegicus 64-82 7824567-4 1994 IL-1 beta (5 ng) diminished food and water consumption by 45 and 30%, respectively, and decreased body weight for at least 24 h postinjection in rats fed ad lib. Water 37-42 interleukin 1 beta Rattus norvegicus 0-9 7921431-0 1994 Role of nitric oxide and superoxide anions in interleukin-1 beta-induced airway hyperresponsiveness to bradykinin. Nitric Oxide 8-20 interleukin 1 beta Rattus norvegicus 46-64 7526844-1 1994 In cultured glomerular mesangial cells, interleukin 1 beta (IL-1 beta) has been shown to induce a dose- and time-dependent accumulation of nitrite, a stable metabolite of nitric oxide (NO). Nitrites 139-146 interleukin 1 beta Rattus norvegicus 40-58 7526844-1 1994 In cultured glomerular mesangial cells, interleukin 1 beta (IL-1 beta) has been shown to induce a dose- and time-dependent accumulation of nitrite, a stable metabolite of nitric oxide (NO). Nitrites 139-146 interleukin 1 beta Rattus norvegicus 60-69 7526844-1 1994 In cultured glomerular mesangial cells, interleukin 1 beta (IL-1 beta) has been shown to induce a dose- and time-dependent accumulation of nitrite, a stable metabolite of nitric oxide (NO). Nitric Oxide 171-183 interleukin 1 beta Rattus norvegicus 40-58 7526844-1 1994 In cultured glomerular mesangial cells, interleukin 1 beta (IL-1 beta) has been shown to induce a dose- and time-dependent accumulation of nitrite, a stable metabolite of nitric oxide (NO). Nitric Oxide 171-183 interleukin 1 beta Rattus norvegicus 60-69 7526844-3 1994 Here we report that addition of the biologically active phorbol esters, phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), dose-dependently inhibited the IL-1 beta-stimulated increase in iNOS mRNA levels and nitrite production. Phorbol Esters 56-70 interleukin 1 beta Rattus norvegicus 178-187 7526844-3 1994 Here we report that addition of the biologically active phorbol esters, phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), dose-dependently inhibited the IL-1 beta-stimulated increase in iNOS mRNA levels and nitrite production. Tetradecanoylphorbol Acetate 72-103 interleukin 1 beta Rattus norvegicus 178-187 7526844-3 1994 Here we report that addition of the biologically active phorbol esters, phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), dose-dependently inhibited the IL-1 beta-stimulated increase in iNOS mRNA levels and nitrite production. Tetradecanoylphorbol Acetate 105-108 interleukin 1 beta Rattus norvegicus 178-187 7526844-3 1994 Here we report that addition of the biologically active phorbol esters, phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), dose-dependently inhibited the IL-1 beta-stimulated increase in iNOS mRNA levels and nitrite production. Phorbol 12,13-Dibutyrate 114-138 interleukin 1 beta Rattus norvegicus 178-187 7526844-3 1994 Here we report that addition of the biologically active phorbol esters, phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), dose-dependently inhibited the IL-1 beta-stimulated increase in iNOS mRNA levels and nitrite production. Phorbol 12,13-Dibutyrate 140-144 interleukin 1 beta Rattus norvegicus 178-187 7526844-3 1994 Here we report that addition of the biologically active phorbol esters, phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), dose-dependently inhibited the IL-1 beta-stimulated increase in iNOS mRNA levels and nitrite production. Nitrites 232-239 interleukin 1 beta Rattus norvegicus 178-187 7526844-8 1994 In contrast, a 24 h treatment of mesangial cells with PMA or PDBu, a regimen that also causes depletion of PKC-epsilon, abolished inhibition of IL-1 beta-induced iNOS expression and nitrite production. Nitrites 182-189 interleukin 1 beta Rattus norvegicus 144-153 7921431-0 1994 Role of nitric oxide and superoxide anions in interleukin-1 beta-induced airway hyperresponsiveness to bradykinin. Superoxides 25-42 interleukin 1 beta Rattus norvegicus 46-64 7523451-0 1994 The morphogenic/cytotoxic and prostaglandin-stimulating activities of interleukin-1 beta in the rat ovary are nitric oxide independent. Prostaglandins 30-43 interleukin 1 beta Rattus norvegicus 70-88 7847613-1 1994 We have previously shown that following prenatal alcohol exposure, immature offspring showed blunted ACTH released in response to the peripheral administration of interleukin-1 beta (IL-1 beta). Alcohols 49-56 interleukin 1 beta Rattus norvegicus 163-181 7847613-1 1994 We have previously shown that following prenatal alcohol exposure, immature offspring showed blunted ACTH released in response to the peripheral administration of interleukin-1 beta (IL-1 beta). Alcohols 49-56 interleukin 1 beta Rattus norvegicus 183-192 7847613-8 1994 Finally, we observed that inhibition of NO formation by the administration of the arginine derivative L omega nitro-L-arginine-methylester significantly augmented ACTH secretion in all three experimental groups, and reversed the decreased corticotrophs" response to IL-1 beta caused by prenatal alcohol. Arginine 82-90 interleukin 1 beta Rattus norvegicus 266-275 7847613-8 1994 Finally, we observed that inhibition of NO formation by the administration of the arginine derivative L omega nitro-L-arginine-methylester significantly augmented ACTH secretion in all three experimental groups, and reversed the decreased corticotrophs" response to IL-1 beta caused by prenatal alcohol. l omega nitro-l-arginine 102-126 interleukin 1 beta Rattus norvegicus 266-275 7847613-9 1994 Taken together, our results suggest that the ability of prenatal alcohol exposure to alter ACTH released by immature pups in response to blood-borne IL-1 beta is probably not mediated through changes in adrenal responsiveness. Alcohols 65-72 interleukin 1 beta Rattus norvegicus 149-158 7524482-6 1994 Thaliporphine (0.1-100 microM) dose-dependently inhibited nitrite accumulation in macrophages stimulated by interleukin-1 beta (IL-1 beta) whereas nitrite formation induced by tumour necrosis factor alpha was not inhibited. thaliporphine 0-13 interleukin 1 beta Rattus norvegicus 108-126 7524482-6 1994 Thaliporphine (0.1-100 microM) dose-dependently inhibited nitrite accumulation in macrophages stimulated by interleukin-1 beta (IL-1 beta) whereas nitrite formation induced by tumour necrosis factor alpha was not inhibited. thaliporphine 0-13 interleukin 1 beta Rattus norvegicus 128-137 7524482-6 1994 Thaliporphine (0.1-100 microM) dose-dependently inhibited nitrite accumulation in macrophages stimulated by interleukin-1 beta (IL-1 beta) whereas nitrite formation induced by tumour necrosis factor alpha was not inhibited. Nitrites 58-65 interleukin 1 beta Rattus norvegicus 108-126 7524482-6 1994 Thaliporphine (0.1-100 microM) dose-dependently inhibited nitrite accumulation in macrophages stimulated by interleukin-1 beta (IL-1 beta) whereas nitrite formation induced by tumour necrosis factor alpha was not inhibited. Nitrites 58-65 interleukin 1 beta Rattus norvegicus 128-137 7524482-7 1994 LPS-stimulated IL-1 beta synthesis in macrophages was significantly inhibited by thaliporphine, but thaliporphine had only minimal effect on LPS-stimulated IL-1 beta synthesis in endothelial cells. thaliporphine 81-94 interleukin 1 beta Rattus norvegicus 15-24 7524482-8 1994 These results demonstrate that thaliporphine inhibits LPS induction of NO synthase expression, and that the mechanism of action of thaliporphine is via inhibition of LPS-stimulated IL-1 beta synthesis in macrophages. thaliporphine 131-144 interleukin 1 beta Rattus norvegicus 181-190 7523451-0 1994 The morphogenic/cytotoxic and prostaglandin-stimulating activities of interleukin-1 beta in the rat ovary are nitric oxide independent. Nitric Oxide 110-122 interleukin 1 beta Rattus norvegicus 70-88 7523451-2 1994 Since the cytokine interleukin-1 beta (IL-1 beta) induces nitric oxide synthase (NOS) activity as well as effects morphogenic/cytotoxic changes and increased prostaglandin (PGE2) levels in cultured whole ovarian dispersates, we set out to determine whether these actions are interrelated. nitric 58-64 interleukin 1 beta Rattus norvegicus 19-37 7523451-2 1994 Since the cytokine interleukin-1 beta (IL-1 beta) induces nitric oxide synthase (NOS) activity as well as effects morphogenic/cytotoxic changes and increased prostaglandin (PGE2) levels in cultured whole ovarian dispersates, we set out to determine whether these actions are interrelated. nitric 58-64 interleukin 1 beta Rattus norvegicus 39-48 7523451-2 1994 Since the cytokine interleukin-1 beta (IL-1 beta) induces nitric oxide synthase (NOS) activity as well as effects morphogenic/cytotoxic changes and increased prostaglandin (PGE2) levels in cultured whole ovarian dispersates, we set out to determine whether these actions are interrelated. Prostaglandins 158-171 interleukin 1 beta Rattus norvegicus 19-37 7523451-2 1994 Since the cytokine interleukin-1 beta (IL-1 beta) induces nitric oxide synthase (NOS) activity as well as effects morphogenic/cytotoxic changes and increased prostaglandin (PGE2) levels in cultured whole ovarian dispersates, we set out to determine whether these actions are interrelated. Prostaglandins 158-171 interleukin 1 beta Rattus norvegicus 39-48 7964313-1 1994 The aim of the present investigation was to evaluate the putative involvement of oxygen free radicals in interleukin-1 beta (IL-1 beta)-induced suppression of islet glucose oxidation. oxygen free radicals 81-101 interleukin 1 beta Rattus norvegicus 105-123 7964313-1 1994 The aim of the present investigation was to evaluate the putative involvement of oxygen free radicals in interleukin-1 beta (IL-1 beta)-induced suppression of islet glucose oxidation. oxygen free radicals 81-101 interleukin 1 beta Rattus norvegicus 125-134 7523451-2 1994 Since the cytokine interleukin-1 beta (IL-1 beta) induces nitric oxide synthase (NOS) activity as well as effects morphogenic/cytotoxic changes and increased prostaglandin (PGE2) levels in cultured whole ovarian dispersates, we set out to determine whether these actions are interrelated. Dinoprostone 173-177 interleukin 1 beta Rattus norvegicus 19-37 7964313-1 1994 The aim of the present investigation was to evaluate the putative involvement of oxygen free radicals in interleukin-1 beta (IL-1 beta)-induced suppression of islet glucose oxidation. Glucose 165-172 interleukin 1 beta Rattus norvegicus 105-123 7964313-1 1994 The aim of the present investigation was to evaluate the putative involvement of oxygen free radicals in interleukin-1 beta (IL-1 beta)-induced suppression of islet glucose oxidation. Glucose 165-172 interleukin 1 beta Rattus norvegicus 125-134 7523451-2 1994 Since the cytokine interleukin-1 beta (IL-1 beta) induces nitric oxide synthase (NOS) activity as well as effects morphogenic/cytotoxic changes and increased prostaglandin (PGE2) levels in cultured whole ovarian dispersates, we set out to determine whether these actions are interrelated. Dinoprostone 173-177 interleukin 1 beta Rattus norvegicus 39-48 7964313-5 1994 It was found that IL-1 beta induced a marked increase in islet nitrite production, as an index of nitric oxide formation, and that this was paralleled by a decrease in islet glucose oxidation rates. Nitrites 63-70 interleukin 1 beta Rattus norvegicus 18-27 7964313-5 1994 It was found that IL-1 beta induced a marked increase in islet nitrite production, as an index of nitric oxide formation, and that this was paralleled by a decrease in islet glucose oxidation rates. Nitric Oxide 98-110 interleukin 1 beta Rattus norvegicus 18-27 7523451-3 1994 Treatment with IL-1 beta resulted in a marked increase in media nitrite and nitrate accumulation, morphological alterations, and increased release of lactate dehydrogenase (LDH) into media. Nitrites 64-71 interleukin 1 beta Rattus norvegicus 15-24 7964313-5 1994 It was found that IL-1 beta induced a marked increase in islet nitrite production, as an index of nitric oxide formation, and that this was paralleled by a decrease in islet glucose oxidation rates. Glucose 174-181 interleukin 1 beta Rattus norvegicus 18-27 7827626-0 1994 The hypothalamic peptides, beta-endorphin, neuropeptide K and interleukin-1 beta, and the opiate morphine, enhance the excitatory amino acid-induced LH release under the influence of gonadal steroids. Excitatory Amino Acids 119-140 interleukin 1 beta Rattus norvegicus 62-80 7523451-3 1994 Treatment with IL-1 beta resulted in a marked increase in media nitrite and nitrate accumulation, morphological alterations, and increased release of lactate dehydrogenase (LDH) into media. Nitrates 76-83 interleukin 1 beta Rattus norvegicus 15-24 7827626-0 1994 The hypothalamic peptides, beta-endorphin, neuropeptide K and interleukin-1 beta, and the opiate morphine, enhance the excitatory amino acid-induced LH release under the influence of gonadal steroids. Luteinizing Hormone 149-151 interleukin 1 beta Rattus norvegicus 62-80 7827626-0 1994 The hypothalamic peptides, beta-endorphin, neuropeptide K and interleukin-1 beta, and the opiate morphine, enhance the excitatory amino acid-induced LH release under the influence of gonadal steroids. Steroids 191-199 interleukin 1 beta Rattus norvegicus 62-80 7523451-6 1994 Similarly, treatment with transforming growth factor beta 1, inhibited IL-1 beta-induced nitrite accumulation, but had no effect on the morphologic or cytotoxic endpoints. Nitrites 89-96 interleukin 1 beta Rattus norvegicus 71-80 7523451-7 1994 Moreover, the addition of sodium nitroprusside, an NO generator, resulted in progressive increments in media nitrite content without a corresponding increase in the IL-1 beta-associated morphogenic changes or media LDH content. Nitroprusside 26-46 interleukin 1 beta Rattus norvegicus 165-174 7524486-3 1994 Actinomycin D, an inhibitor of gene transcription, prevented IL-1 beta induction of both MnSOD and iNOS mRNA. Dactinomycin 0-13 interleukin 1 beta Rattus norvegicus 61-70 7820367-5 1994 Alcohol, which by itself did not stimulate c-fos or NGFI-B mRNA levels in the paraventricular nucleus of the hypothalamus, significantly blunted the ability of icv IL-1 beta to increase the expression of these immediate early genes. Alcohols 0-7 interleukin 1 beta Rattus norvegicus 164-173 7820367-6 1994 We conclude that the inhibitory influence exerted by prior alcohol treatment on ACTH released by icv administered IL-1 beta may reflect an interference with the stimulatory influence of the cytokine on hypothalamic neurons involved in the activation of the hypothalamic-pituitary-adrenal axis. Alcohols 59-66 interleukin 1 beta Rattus norvegicus 114-123 7524486-4 1994 Cycloheximide, an inhibitor of protein synthesis, prevented IL-1 beta-induced expression of iNOS mRNA, but not MnSOD mRNA. Cycloheximide 0-13 interleukin 1 beta Rattus norvegicus 60-69 7530059-0 1994 Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases. Nitric Oxide 64-76 interleukin 1 beta Rattus norvegicus 0-18 7521579-9 1994 Adding a combination of the cytokines interleukin-1 beta, tumor necrosis factor-alpha, and interferon-gamma to both endothelial cell cultures led to a dramatic increase of nitric oxide formation. Nitric Oxide 172-184 interleukin 1 beta Rattus norvegicus 38-85 7945286-3 1994 In contrast, although spontaneous release of KC/gro protein from the hepatocytes of chronically ethanol-fed rats was markedly enhanced as compared with control rats, the relative increase by stimulation with lipopolysaccharide, IL-1 beta or TNF-alpha was significantly smaller than in controls. Ethanol 96-103 interleukin 1 beta Rattus norvegicus 228-237 7530059-3 1994 Inhibition of both the constitutive and the inducible forms of nitric oxide synthase prevented IL-1 beta-induced fever, hyperglycaemia, hypoinsulinemia, and hyperglucagonemia, and partially prevented lymphopenia and neutrophilia, but had no effect on IL-1 beta-induced anorexia and changes in plasma corticosterone. Corticosterone 300-314 interleukin 1 beta Rattus norvegicus 95-104 7530059-4 1994 Preferential inhibition of the inducible form of nitric oxide synthase using two daily injections of 5 mg/rat of aminoguanidine prevented IL-1 beta-induced hyperglycaemia and hypoinsulinaemia, and slightly reduced the pyrogenicity of IL-1 on 3 out of 5 days. pimagedine 113-127 interleukin 1 beta Rattus norvegicus 138-147 7530059-6 1994 We conclude that nitric oxide produced by the inducible form of nitric oxide synthase, mediates the IL-1 beta-induced inhibition of insulin release and that the effect of IL-1 beta on temperature, pancreatic alpha-cells, and leukocyte differential counts seems to be mediated by nitric oxide produced by the constitutive form of nitric oxide synthase. Nitric Oxide 17-29 interleukin 1 beta Rattus norvegicus 100-109 7530059-6 1994 We conclude that nitric oxide produced by the inducible form of nitric oxide synthase, mediates the IL-1 beta-induced inhibition of insulin release and that the effect of IL-1 beta on temperature, pancreatic alpha-cells, and leukocyte differential counts seems to be mediated by nitric oxide produced by the constitutive form of nitric oxide synthase. Nitric Oxide 64-76 interleukin 1 beta Rattus norvegicus 100-109 7532327-6 1994 With L-NAME and IL-1 beta, both plasma AVP and ANH increased, and depressor response to IL-1 beta was partly attenuated by L-NAME, without any changes in RT. NG-Nitroarginine Methyl Ester 5-11 interleukin 1 beta Rattus norvegicus 88-97 7532327-6 1994 With L-NAME and IL-1 beta, both plasma AVP and ANH increased, and depressor response to IL-1 beta was partly attenuated by L-NAME, without any changes in RT. NG-Nitroarginine Methyl Ester 123-129 interleukin 1 beta Rattus norvegicus 16-25 7532327-6 1994 With L-NAME and IL-1 beta, both plasma AVP and ANH increased, and depressor response to IL-1 beta was partly attenuated by L-NAME, without any changes in RT. NG-Nitroarginine Methyl Ester 123-129 interleukin 1 beta Rattus norvegicus 88-97 8074648-0 1994 Interleukin-1 beta induced activation of NF-kappa B in insulin producing RINm5F cells is prevented by the protease inhibitor N alpha-p-tosyl-L-lysine chloromethylketone. n alpha-p-tosyl-l-lysine chloromethylketone 125-168 interleukin 1 beta Rattus norvegicus 0-18 8074648-1 1994 The cytokine Interleukin-1 beta (IL-1 beta) is known to exert cytotoxic effects upon rodent beta-cells in vitro by inducing nitric oxide production and has therefore been suggested to play a role in the pathogenesis of insulin-dependent diabetes mellitus (IDDM). Nitric Oxide 124-136 interleukin 1 beta Rattus norvegicus 13-31 8074648-1 1994 The cytokine Interleukin-1 beta (IL-1 beta) is known to exert cytotoxic effects upon rodent beta-cells in vitro by inducing nitric oxide production and has therefore been suggested to play a role in the pathogenesis of insulin-dependent diabetes mellitus (IDDM). Nitric Oxide 124-136 interleukin 1 beta Rattus norvegicus 33-42 8074648-2 1994 Using the insulin producing rat cell line RINm5F and an electrophoretic mobility shift assay (EMSA), it was presently found that IL-1 beta induced a rapid activation (5 min) of the transcription factor NF-kappa B and that this event was prevented by the protease inhibitor N alpha-p-tosyl-L-lysine chloromethylketone (TLCK). rinm5f 42-48 interleukin 1 beta Rattus norvegicus 129-138 8074648-2 1994 Using the insulin producing rat cell line RINm5F and an electrophoretic mobility shift assay (EMSA), it was presently found that IL-1 beta induced a rapid activation (5 min) of the transcription factor NF-kappa B and that this event was prevented by the protease inhibitor N alpha-p-tosyl-L-lysine chloromethylketone (TLCK). n alpha-p-tosyl-l-lysine chloromethylketone 273-316 interleukin 1 beta Rattus norvegicus 129-138 8074648-3 1994 TLCK prevented also IL-1 beta induced nitric oxide production. Nitric Oxide 38-50 interleukin 1 beta Rattus norvegicus 20-29 7978115-1 1994 We have previously reported that when compared with animals fed ad libitum, adult ovariectomized (OVX) female rats fed an alcohol diet, but not its isocaloric equivalent control, showed a blunted ACTH response to the intravenous injection of interleukin-1 beta (IL-1 beta). Alcohols 122-129 interleukin 1 beta Rattus norvegicus 242-260 8073054-9 1994 AZn IL-1 beta-infused rats were characterized by high liver Fe, Zn, and metallothionein (MT) concentrations on Day 1; by Day 7, only MT concentrations remained elevated. Alizarin Red S 0-3 interleukin 1 beta Rattus norvegicus 4-13 8073054-9 1994 AZn IL-1 beta-infused rats were characterized by high liver Fe, Zn, and metallothionein (MT) concentrations on Day 1; by Day 7, only MT concentrations remained elevated. Iron 60-62 interleukin 1 beta Rattus norvegicus 4-13 8073054-9 1994 AZn IL-1 beta-infused rats were characterized by high liver Fe, Zn, and metallothionein (MT) concentrations on Day 1; by Day 7, only MT concentrations remained elevated. Zinc 1-3 interleukin 1 beta Rattus norvegicus 4-13 8073054-10 1994 Liver MnSOD activity was 13%-29% higher in both the AZn- and MZn-IL-1 beta-infused rats than their respective controls on Day 3 and Day 7, with most significant increase observed on Day 7. MZN 61-64 interleukin 1 beta Rattus norvegicus 65-74 8073054-11 1994 These data show that Zn status can influence the response to low-dose IL-1 beta; this influence of Zn should be considered when IL-1 beta is given therapeutically. Zinc 21-23 interleukin 1 beta Rattus norvegicus 70-79 8001644-12 1994 was enhanced in smooth muscle cells from both normotensive and hypertensive rats when the cells were treated with L-arginine after exposure to interleukin-1 beta. Arginine 114-124 interleukin 1 beta Rattus norvegicus 143-161 8073054-2 1994 In the present study, the influence of Zn status on the response to continuous low-dose IL-1 beta administration was evaluated. Zinc 39-41 interleukin 1 beta Rattus norvegicus 88-97 8073054-5 1994 In the AZn rats, IL-1 beta infusion resulted in increased plasma copper (Cu) concentrations and ceruloplasmin (Cp) activity, and decreased iron (Fe) concentrations throughout the 7d period. Alizarin Red S 7-10 interleukin 1 beta Rattus norvegicus 17-26 8073054-5 1994 In the AZn rats, IL-1 beta infusion resulted in increased plasma copper (Cu) concentrations and ceruloplasmin (Cp) activity, and decreased iron (Fe) concentrations throughout the 7d period. Copper 65-71 interleukin 1 beta Rattus norvegicus 17-26 8073054-5 1994 In the AZn rats, IL-1 beta infusion resulted in increased plasma copper (Cu) concentrations and ceruloplasmin (Cp) activity, and decreased iron (Fe) concentrations throughout the 7d period. Copper 73-75 interleukin 1 beta Rattus norvegicus 17-26 8073054-5 1994 In the AZn rats, IL-1 beta infusion resulted in increased plasma copper (Cu) concentrations and ceruloplasmin (Cp) activity, and decreased iron (Fe) concentrations throughout the 7d period. Iron 139-143 interleukin 1 beta Rattus norvegicus 17-26 8073054-5 1994 In the AZn rats, IL-1 beta infusion resulted in increased plasma copper (Cu) concentrations and ceruloplasmin (Cp) activity, and decreased iron (Fe) concentrations throughout the 7d period. Iron 145-147 interleukin 1 beta Rattus norvegicus 17-26 8073054-7 1994 A similar trend was observed in the MZn rats, but IL-1 beta-induced increases in plasma Cu and Cp activity were less than in the AZn fed rats. Copper 88-90 interleukin 1 beta Rattus norvegicus 50-59 8073054-8 1994 In MZn and AZn IL-1 beta infused rats, plasma Zn was decreased on Day 1, and Day 3, respectively, compared with their respective controls. Alizarin Red S 11-14 interleukin 1 beta Rattus norvegicus 15-24 7519435-3 1994 We found that type II cells synthesize significant quantities of nitric oxide after treatment with the inflammatory cytokines, interferon-gamma (IFN-gamma) and/or interleukin-1 beta (IL-1 beta), or with the combination of IFN-gamma and tumor necrosis factor-alpha. Nitric Oxide 65-77 interleukin 1 beta Rattus norvegicus 163-181 7519435-3 1994 We found that type II cells synthesize significant quantities of nitric oxide after treatment with the inflammatory cytokines, interferon-gamma (IFN-gamma) and/or interleukin-1 beta (IL-1 beta), or with the combination of IFN-gamma and tumor necrosis factor-alpha. Nitric Oxide 65-77 interleukin 1 beta Rattus norvegicus 183-192 7978115-1 1994 We have previously reported that when compared with animals fed ad libitum, adult ovariectomized (OVX) female rats fed an alcohol diet, but not its isocaloric equivalent control, showed a blunted ACTH response to the intravenous injection of interleukin-1 beta (IL-1 beta). Alcohols 122-129 interleukin 1 beta Rattus norvegicus 262-271 7519435-9 1994 Cells from ozone-treated rats were also sensitized to produce more nitric oxide in response to IFN-gamma and IL-1 beta. Nitric Oxide 67-79 interleukin 1 beta Rattus norvegicus 109-118 7524699-0 1994 Interleukin-1 beta stimulates nitrite production in the rat ovary: evidence for heterologous cell-cell interaction and for insulin-mediated regulation of the inducible isoform of nitric oxide synthase. Nitrites 30-37 interleukin 1 beta Rattus norvegicus 0-18 7524699-2 1994 In an effort to determine whether NO generation mediates any of the intraovarian actions of interleukin-1 beta (IL-1 beta), we have looked for and characterized the accumulation of nitrite by IL-1 beta-treated, cultured whole ovarian dispersates. Nitrites 181-188 interleukin 1 beta Rattus norvegicus 192-201 7524699-3 1994 Application of IL-1 beta significantly enhanced basal nitrite release in a dose-, cell density- and time-dependent manner, the latter characterized by a lag time of about 20 h, suggestive of induction of NO synthase (NOS). Nitrites 54-61 interleukin 1 beta Rattus norvegicus 15-24 7524699-5 1994 Sustained nitrite accumulation required continuous application of IL-1 beta. Nitrites 10-17 interleukin 1 beta Rattus norvegicus 66-75 7524699-6 1994 The maximally stimulating dose of IL-1 beta (50 ng/ml) produced a 10-fold increase in nitrite accumulation by 96 h of culture, an effect reduced 23% when cells were cultured in substrate (i.e., arginine)-free media. Nitrites 86-93 interleukin 1 beta Rattus norvegicus 34-43 7524699-6 1994 The maximally stimulating dose of IL-1 beta (50 ng/ml) produced a 10-fold increase in nitrite accumulation by 96 h of culture, an effect reduced 23% when cells were cultured in substrate (i.e., arginine)-free media. Arginine 194-202 interleukin 1 beta Rattus norvegicus 34-43 7524699-7 1994 IL-1 beta-stimulated nitrite accumulation was reduced to control levels by the simultaneous application of an IL-1 beta receptor antagonist, thereby suggesting a specific receptor-mediated effect. Nitrites 21-28 interleukin 1 beta Rattus norvegicus 0-9 7524699-7 1994 IL-1 beta-stimulated nitrite accumulation was reduced to control levels by the simultaneous application of an IL-1 beta receptor antagonist, thereby suggesting a specific receptor-mediated effect. Nitrites 21-28 interleukin 1 beta Rattus norvegicus 110-119 7524699-8 1994 Both the control and IL-1 beta-stimulated levels of nitrite accumulation were attenuated in a dose-dependent manner by inhibitors that favor the inducible form of NOS. Nitrites 52-59 interleukin 1 beta Rattus norvegicus 21-30 7524699-11 1994 IL-1 beta-induced nitrite accumulation was shown to require cell-cell interaction between granulosa and theca-interstitial cells. Nitrites 18-25 interleukin 1 beta Rattus norvegicus 0-9 8035171-2 1994 Treatment of astrocytes with interleukin-1 beta (IL-1) or the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased NGF mRNA content by six- to 10-fold, followed in time by increases in cell content and cell secretion of NGF. Tetradecanoylphorbol Acetate 133-136 interleukin 1 beta Rattus norvegicus 29-47 7931009-4 1994 We have found that the ability of IL-1 beta to increase plasma AVP is strongly influenced by circulating levels of glucocorticoid steroids. Steroids 130-138 interleukin 1 beta Rattus norvegicus 34-43 7990272-3 1994 Both KCA-098 and ipriflavone inhibited parathyroid hormone-, prostaglandin E2-, 1 alpha,25-dihydroxyvitamin D3- and interleukin 1 beta-induced bone resorption of fetal rat bones, but the inhibitory activity of KCA-098 was more potent than that of ipriflavone. KCA 098 5-12 interleukin 1 beta Rattus norvegicus 75-134 7990272-3 1994 Both KCA-098 and ipriflavone inhibited parathyroid hormone-, prostaglandin E2-, 1 alpha,25-dihydroxyvitamin D3- and interleukin 1 beta-induced bone resorption of fetal rat bones, but the inhibitory activity of KCA-098 was more potent than that of ipriflavone. ipriflavone 17-28 interleukin 1 beta Rattus norvegicus 75-134 7521513-1 1994 Rat aortic smooth muscle cells produced large quantities of nitric oxide (NO) after exposure to interleukin-1 beta, and this was depressed in the presence of the protein kinase C inhibitor bisindolylmaleimide. Nitric Oxide 60-72 interleukin 1 beta Rattus norvegicus 96-114 7522931-4 1994 IL-1 beta induced a dual increase in 5HIAA levels: a rapid, short-term rise was followed by a lasting increase possibly due to newly synthesized IL-1. Hydroxyindoleacetic Acid 37-42 interleukin 1 beta Rattus norvegicus 0-9 7521513-1 1994 Rat aortic smooth muscle cells produced large quantities of nitric oxide (NO) after exposure to interleukin-1 beta, and this was depressed in the presence of the protein kinase C inhibitor bisindolylmaleimide. bisindolylmaleimide 189-208 interleukin 1 beta Rattus norvegicus 96-114 7521513-3 1994 Inhibition of GTP:cyclohydrolase I by 2,4-diamino-6-hydroxypyrimidine attenuated NO production by interleukin-1 beta-treated cells. Guanosine Triphosphate 14-17 interleukin 1 beta Rattus norvegicus 98-116 7521513-3 1994 Inhibition of GTP:cyclohydrolase I by 2,4-diamino-6-hydroxypyrimidine attenuated NO production by interleukin-1 beta-treated cells. 2,4-diaminohypoxanthine 38-69 interleukin 1 beta Rattus norvegicus 98-116 7522931-5 1994 The synthetic glucocorticoid dexamethasone (DEX, 3 mg/kg i.p., 30 min before IL-1 beta), prevented the effect of IL-1 beta starting from 150 min, suggesting that it only inhibited the second increase. Dexamethasone 29-42 interleukin 1 beta Rattus norvegicus 77-86 7957631-0 1994 Nitric oxide mediates the amplification by interleukin-1 beta of neurogenic vasodilatation in the rat skin. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 43-61 7957631-2 1994 Intraplantar injection of interleukin-1 beta (50 pg) significantly enhanced the hyperaemic response to intraplantar capsaicin (0.3 microgram). Capsaicin 116-125 interleukin 1 beta Rattus norvegicus 26-44 7522931-5 1994 The synthetic glucocorticoid dexamethasone (DEX, 3 mg/kg i.p., 30 min before IL-1 beta), prevented the effect of IL-1 beta starting from 150 min, suggesting that it only inhibited the second increase. Dexamethasone 29-42 interleukin 1 beta Rattus norvegicus 113-122 7957631-3 1994 Pretreatment with a neurotoxic dose of capsaicin reduced the capsaicin-evoked hyperaemia and prevented the facilitatory effect of interleukin-1 beta. Capsaicin 39-48 interleukin 1 beta Rattus norvegicus 130-148 7522931-5 1994 The synthetic glucocorticoid dexamethasone (DEX, 3 mg/kg i.p., 30 min before IL-1 beta), prevented the effect of IL-1 beta starting from 150 min, suggesting that it only inhibited the second increase. Dexamethasone 44-47 interleukin 1 beta Rattus norvegicus 113-122 7957631-4 1994 Blockade of nitric oxide formation by NG-nitro-L-arginine methyl ester failed to affect the capsaicin-evoked vasodilatation but abolished its amplification by interleukin-1 beta. NG-Nitroarginine Methyl Ester 38-70 interleukin 1 beta Rattus norvegicus 159-177 7522931-7 1994 The glucocorticoid receptor antagonist RU38486 (25 mg/kg s.c., 60 min before IL-1 beta) completely prevented IL-1 beta activation of the serotonergic system. Mifepristone 39-46 interleukin 1 beta Rattus norvegicus 77-86 7957631-5 1994 These data indicate that the enhancement by interleukin-1 beta of the capsaicin-induced hyperaemia involves thin afferent nerve fibres and depends on nitric oxide as essential intermediate. Capsaicin 70-79 interleukin 1 beta Rattus norvegicus 44-62 7957631-5 1994 These data indicate that the enhancement by interleukin-1 beta of the capsaicin-induced hyperaemia involves thin afferent nerve fibres and depends on nitric oxide as essential intermediate. Nitric Oxide 150-162 interleukin 1 beta Rattus norvegicus 44-62 7522931-7 1994 The glucocorticoid receptor antagonist RU38486 (25 mg/kg s.c., 60 min before IL-1 beta) completely prevented IL-1 beta activation of the serotonergic system. Mifepristone 39-46 interleukin 1 beta Rattus norvegicus 109-118 7517798-10 1994 Dexamethasone inhibited the IL-1 beta-induced NOx production as well as iNOS mRNA expression. nicotine 1-N-oxide 46-49 interleukin 1 beta Rattus norvegicus 28-37 7519400-3 1994 In this report we demonstrate that the cytokine interleukin-1 beta (IL-1 beta) stimulates the expression of iNOS and the formation of nitric oxide (as determined by nitrite formation, a stable oxidative product of nitric oxide) by isolated intact rat islets and by primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitric Oxide 134-146 interleukin 1 beta Rattus norvegicus 48-66 7519400-3 1994 In this report we demonstrate that the cytokine interleukin-1 beta (IL-1 beta) stimulates the expression of iNOS and the formation of nitric oxide (as determined by nitrite formation, a stable oxidative product of nitric oxide) by isolated intact rat islets and by primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitric Oxide 134-146 interleukin 1 beta Rattus norvegicus 68-77 7519400-3 1994 In this report we demonstrate that the cytokine interleukin-1 beta (IL-1 beta) stimulates the expression of iNOS and the formation of nitric oxide (as determined by nitrite formation, a stable oxidative product of nitric oxide) by isolated intact rat islets and by primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitrites 165-172 interleukin 1 beta Rattus norvegicus 48-66 7519400-3 1994 In this report we demonstrate that the cytokine interleukin-1 beta (IL-1 beta) stimulates the expression of iNOS and the formation of nitric oxide (as determined by nitrite formation, a stable oxidative product of nitric oxide) by isolated intact rat islets and by primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitrites 165-172 interleukin 1 beta Rattus norvegicus 68-77 7519400-3 1994 In this report we demonstrate that the cytokine interleukin-1 beta (IL-1 beta) stimulates the expression of iNOS and the formation of nitric oxide (as determined by nitrite formation, a stable oxidative product of nitric oxide) by isolated intact rat islets and by primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitric Oxide 214-226 interleukin 1 beta Rattus norvegicus 48-66 7519400-3 1994 In this report we demonstrate that the cytokine interleukin-1 beta (IL-1 beta) stimulates the expression of iNOS and the formation of nitric oxide (as determined by nitrite formation, a stable oxidative product of nitric oxide) by isolated intact rat islets and by primary beta-cells purified by fluorescence-activated cell sorting (FACS). Nitric Oxide 214-226 interleukin 1 beta Rattus norvegicus 68-77 7519400-4 1994 Both the expression of iNOS and nitrite formation induced by IL-1 beta were prevented by the mRNA transcriptional inhibitor actinomycin D. Nitrites 32-39 interleukin 1 beta Rattus norvegicus 61-70 7519400-4 1994 Both the expression of iNOS and nitrite formation induced by IL-1 beta were prevented by the mRNA transcriptional inhibitor actinomycin D. Dactinomycin 124-137 interleukin 1 beta Rattus norvegicus 61-70 7519400-6 1994 The tyrosine kinase inhibitors genistein and herbimycin A prevented IL-1 beta-induced expression of immunoprecipitable iNOS and nitrite release by islets, by insulinoma RINm5F cells, and by FACS-purified beta-cells. Genistein 31-40 interleukin 1 beta Rattus norvegicus 68-77 7519400-6 1994 The tyrosine kinase inhibitors genistein and herbimycin A prevented IL-1 beta-induced expression of immunoprecipitable iNOS and nitrite release by islets, by insulinoma RINm5F cells, and by FACS-purified beta-cells. herbimycin 45-57 interleukin 1 beta Rattus norvegicus 68-77 7519400-6 1994 The tyrosine kinase inhibitors genistein and herbimycin A prevented IL-1 beta-induced expression of immunoprecipitable iNOS and nitrite release by islets, by insulinoma RINm5F cells, and by FACS-purified beta-cells. Nitrites 128-135 interleukin 1 beta Rattus norvegicus 68-77 7519400-7 1994 Herbimycin A and genistein also prevented IL-1 beta-induced iNOS mRNA accumulation as determined by Northern blot analysis of total RNA isolated from RINm5F cells. herbimycin 0-12 interleukin 1 beta Rattus norvegicus 42-51 7519400-7 1994 Herbimycin A and genistein also prevented IL-1 beta-induced iNOS mRNA accumulation as determined by Northern blot analysis of total RNA isolated from RINm5F cells. Genistein 17-26 interleukin 1 beta Rattus norvegicus 42-51 7517798-4 1994 IL-1 beta dose-dependently (0.1 to 10 ng/mL) stimulated NOx production as a function of time (6 to 48 hours). nicotine 1-N-oxide 56-59 interleukin 1 beta Rattus norvegicus 0-9 7517798-9 1994 NG-mono-methyl-L-arginine, an NOS inhibitor, completely blocked the IL-1 beta-induced NOx production, whose effect was reversed by L-arginine but not by D-arginine. omega-N-Methylarginine 0-25 interleukin 1 beta Rattus norvegicus 68-77 7517798-9 1994 NG-mono-methyl-L-arginine, an NOS inhibitor, completely blocked the IL-1 beta-induced NOx production, whose effect was reversed by L-arginine but not by D-arginine. nicotine 1-N-oxide 86-89 interleukin 1 beta Rattus norvegicus 68-77 7517798-9 1994 NG-mono-methyl-L-arginine, an NOS inhibitor, completely blocked the IL-1 beta-induced NOx production, whose effect was reversed by L-arginine but not by D-arginine. Arginine 15-25 interleukin 1 beta Rattus norvegicus 68-77 7517798-10 1994 Dexamethasone inhibited the IL-1 beta-induced NOx production as well as iNOS mRNA expression. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 28-37 7517798-11 1994 Cycloheximide and actinomycin D completely inhibited the IL-1 beta-induced NOx production and iNOS mRNA expression. Cycloheximide 0-13 interleukin 1 beta Rattus norvegicus 57-66 7517798-11 1994 Cycloheximide and actinomycin D completely inhibited the IL-1 beta-induced NOx production and iNOS mRNA expression. Dactinomycin 18-31 interleukin 1 beta Rattus norvegicus 57-66 7517798-11 1994 Cycloheximide and actinomycin D completely inhibited the IL-1 beta-induced NOx production and iNOS mRNA expression. nicotine 1-N-oxide 75-78 interleukin 1 beta Rattus norvegicus 57-66 8028504-4 1994 IL-1 beta and TNF alpha potentiated glucagon-induced total amino acid uptake by 56% and 87%, respectively. Glucagon 36-44 interleukin 1 beta Rattus norvegicus 0-9 8020588-0 1994 Interleukin-1 beta-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells. Nitric Oxide 27-39 interleukin 1 beta Rattus norvegicus 0-18 8020588-2 1994 This and other adverse effects of cytokines, including interleukin-1 beta (IL-1 beta) involve the induction of nitric oxide synthase, with production of nitric oxide. Nitric Oxide 111-123 interleukin 1 beta Rattus norvegicus 55-73 8020588-2 1994 This and other adverse effects of cytokines, including interleukin-1 beta (IL-1 beta) involve the induction of nitric oxide synthase, with production of nitric oxide. Nitric Oxide 111-123 interleukin 1 beta Rattus norvegicus 75-84 8020588-6 1994 Inhibition of the nitric oxide synthase activity by NG-monomethyl-L-arginine prevented IL-1 beta-induced nitric oxide generation and apoptotic cell killing. nitric 18-24 interleukin 1 beta Rattus norvegicus 87-96 8020588-6 1994 Inhibition of the nitric oxide synthase activity by NG-monomethyl-L-arginine prevented IL-1 beta-induced nitric oxide generation and apoptotic cell killing. omega-N-Methylarginine 52-76 interleukin 1 beta Rattus norvegicus 87-96 8020588-6 1994 Inhibition of the nitric oxide synthase activity by NG-monomethyl-L-arginine prevented IL-1 beta-induced nitric oxide generation and apoptotic cell killing. Nitric Oxide 18-30 interleukin 1 beta Rattus norvegicus 87-96 8020588-7 1994 These results show that--besides the known alterations in beta-cell function--IL-1 beta-induced nitric oxide production activates the cell death program. Nitric Oxide 96-108 interleukin 1 beta Rattus norvegicus 78-87 7958387-4 1994 On the other hand, hemin partially counteracted the IL-1 beta induced decrease in aconitase activity, glucose oxidation, insulin release and medium insulin accumulation. Glucose 102-109 interleukin 1 beta Rattus norvegicus 52-61 7958387-7 1994 Finally, the protease inhibitor N-alpha-tosyl-L-lysine chloromethyl ketone (TLCK), which protects against IL-1 beta by decreasing nitric oxide production, was found to act additively in combination with hemin in alleviating the IL-1 beta effects. n-alpha-tosyl-l-lysine chloromethyl ketone 32-74 interleukin 1 beta Rattus norvegicus 106-115 7958387-7 1994 Finally, the protease inhibitor N-alpha-tosyl-L-lysine chloromethyl ketone (TLCK), which protects against IL-1 beta by decreasing nitric oxide production, was found to act additively in combination with hemin in alleviating the IL-1 beta effects. n-alpha-tosyl-l-lysine chloromethyl ketone 32-74 interleukin 1 beta Rattus norvegicus 228-237 7958387-7 1994 Finally, the protease inhibitor N-alpha-tosyl-L-lysine chloromethyl ketone (TLCK), which protects against IL-1 beta by decreasing nitric oxide production, was found to act additively in combination with hemin in alleviating the IL-1 beta effects. Hemin 203-208 interleukin 1 beta Rattus norvegicus 228-237 7958387-8 1994 It is proposed that the beneficial effects of hemin against IL-1 beta could be related to scavenging of nitric oxide and/or an increased resistance to nitric oxide production. Nitric Oxide 104-116 interleukin 1 beta Rattus norvegicus 60-69 7958387-8 1994 It is proposed that the beneficial effects of hemin against IL-1 beta could be related to scavenging of nitric oxide and/or an increased resistance to nitric oxide production. Nitric Oxide 151-163 interleukin 1 beta Rattus norvegicus 60-69 7958397-5 1994 In intact islets, this nuclear response was observed after 18 h culture in medium containing rIL-1 beta, with a concomitant decrease in NAD (88.5%). NAD 136-139 interleukin 1 beta Rattus norvegicus 93-103 7958397-9 1994 The nuclear effects of IL-1 beta were modified by nicotinamide (10 mM), an inhibitor of poly(ADP-ribose) synthetase. Niacinamide 50-62 interleukin 1 beta Rattus norvegicus 23-32 8028504-6 1994 Thereafter, IL-1 beta inhibited glucagon action, leading to an hepatic uptake of glucose. Glucagon 32-40 interleukin 1 beta Rattus norvegicus 12-21 8028504-6 1994 Thereafter, IL-1 beta inhibited glucagon action, leading to an hepatic uptake of glucose. Glucose 81-88 interleukin 1 beta Rattus norvegicus 12-21 8090286-5 1994 A significant stimulation of PGE2 by IL-1 beta was observed only in the PVN, and its temporal profile was very similar to those of CRF and AVP in the PVN. Dinoprostone 29-33 interleukin 1 beta Rattus norvegicus 37-46 7521071-0 1994 Cyclic nucleotide regulation of interleukin-1 beta induced nitric oxide synthase expression in vascular smooth muscle cells. Nucleotides, Cyclic 0-17 interleukin 1 beta Rattus norvegicus 32-50 7521071-1 1994 Experiments were performed to examine the effect of cyclic nucleotides on the expression of inducible nitric oxide synthase (iNOS) activity by interleukin-1 beta (IL-1 beta) treated rat aortic smooth muscle cells (SMC). Nucleotides, Cyclic 52-70 interleukin 1 beta Rattus norvegicus 143-161 7521071-1 1994 Experiments were performed to examine the effect of cyclic nucleotides on the expression of inducible nitric oxide synthase (iNOS) activity by interleukin-1 beta (IL-1 beta) treated rat aortic smooth muscle cells (SMC). Nucleotides, Cyclic 52-70 interleukin 1 beta Rattus norvegicus 163-172 7521071-2 1994 Treatment of vascular SMC with IL-1 beta stimulated iNOS mRNA expression and the subsequent release of nitrite, a stable oxidation product of nitric oxide (NO). Nitrites 103-110 interleukin 1 beta Rattus norvegicus 31-40 7521071-2 1994 Treatment of vascular SMC with IL-1 beta stimulated iNOS mRNA expression and the subsequent release of nitrite, a stable oxidation product of nitric oxide (NO). Nitric Oxide 142-154 interleukin 1 beta Rattus norvegicus 31-40 7521071-4 1994 The addition of IL-1 beta and cAMP derivatives resulted in a synergistic enhancement of both iNOS mRNA production and of nitrite formation. Nitrites 121-128 interleukin 1 beta Rattus norvegicus 16-25 7521071-6 1994 The addition of cGMP derivatives modestly increased IL-1 beta-induced SMC nitrite generation without affecting the production of iNOS mRNA. Cyclic GMP 16-20 interleukin 1 beta Rattus norvegicus 52-61 7521071-6 1994 The addition of cGMP derivatives modestly increased IL-1 beta-induced SMC nitrite generation without affecting the production of iNOS mRNA. smc nitrite 70-81 interleukin 1 beta Rattus norvegicus 52-61 18638761-5 1994 Recombinant (r) IL-1beta decreased PRL release from GH3 in a dose-dependent fashion. 3'-dGTP 52-55 interleukin 1 beta Rattus norvegicus 16-24 7919198-5 1994 Intracerebroventricular injections of 100 ng and 200 ng IL-1 beta significantly increased TH activity in the median eminence by 40.6% and 74.7% respectively over the saline-injected control group. Sodium Chloride 166-172 interleukin 1 beta Rattus norvegicus 56-65 8090286-6 1994 These results suggest that PGE2 may be a trigger in the PVN for the activation of CRF and AVP neurons, and thereby ACTH secretion, which follows IL-1 beta injection. Dinoprostone 27-31 interleukin 1 beta Rattus norvegicus 145-154 7515501-2 1994 Stimulation with IL-1 beta alone leads to an approximately 40-fold increase in NOS activity and nitrite synthesis, whereas the elevation of cAMP with forskolin, cholera toxin, salbutamol, or dibutyryl-cAMP for 24 h resulted in a 2- to 12-fold increase in NOS activity. Nitrites 96-103 interleukin 1 beta Rattus norvegicus 17-26 7515501-3 1994 Moreover, the combinations of IL-1 beta with each of the cAMP-elevating agents greatly enhanced NOS activity in a synergistic fashion. Cyclic AMP 57-61 interleukin 1 beta Rattus norvegicus 30-39 7515501-5 1994 IL-1 beta increased NOS mRNA levels in a dose- and time-dependent fashion with a peak of NOS mRNA at 24 h. Dibutyryl-cAMP also increased NOS mRNA levels in mesangial cells in a dose- and time-dependent manner. Cyclic AMP 117-121 interleukin 1 beta Rattus norvegicus 0-9 7515501-9 1994 Moreover, cAMP exposure markedly prolonged the half-life of NOS mRNA from 1 h to 3 h. These data suggest that the level of NOS mRNA is controlled by at least two different signaling pathways, one involving cAMP and the other being triggered by cytokines such as IL-1 beta. Cyclic AMP 10-14 interleukin 1 beta Rattus norvegicus 262-271 7957491-6 1994 Pharmacological glucocorticoid receptor blockade (hormone analogue RU486, Roussel-Uclaf, Paris, France) given 1 h prior to the interleukin treatment, completely abolished the interleukin-1 beta induced increases in urea synthesis. Mifepristone 67-72 interleukin 1 beta Rattus norvegicus 175-193 7515065-5 1994 Here, we demonstrate that IL-1 beta diminished markedly the pp63 production by affecting its mRNA transcription and that the cytokine was able to modify the N-glycosylation process of the protein. Nitrogen 95-96 interleukin 1 beta Rattus norvegicus 26-35 7957491-0 1994 The in vivo effect of interleukin-1 beta on urea synthesis is mediated by glucocorticoids in rats. Urea 44-48 interleukin 1 beta Rattus norvegicus 22-40 8194662-2 1994 IL-1 beta-mediated inhibition of insulin release and damage to beta-cells are associated with intracellular production of nitric oxide (NO) radicals. Nitric Oxide 122-134 interleukin 1 beta Rattus norvegicus 0-9 7957491-3 1994 The effect of interleukin-1 beta on urea synthesis was investigated in rats given a high (10 micrograms kg-1) and a low dose (0.1 microgram kg-1) of recombinant interleukin-1 beta (NOVO, Denmark) 3 h prior to determination of the rate of urea synthesis in vivo. Urea 36-40 interleukin 1 beta Rattus norvegicus 14-32 7957491-6 1994 Pharmacological glucocorticoid receptor blockade (hormone analogue RU486, Roussel-Uclaf, Paris, France) given 1 h prior to the interleukin treatment, completely abolished the interleukin-1 beta induced increases in urea synthesis. Urea 215-219 interleukin 1 beta Rattus norvegicus 175-193 7957491-5 1994 The blood concentration of amino acids fell during interleukin-1 beta treatment, so the effect on urea synthesis was not due solely to increased proteolysis, but was exerted predominantly in the liver. Urea 98-102 interleukin 1 beta Rattus norvegicus 51-69 7957491-7 1994 The study demonstrates that interleukin-1 beta stimulates urea synthesis in vivo, and that the major part of the effect depends on glucocorticoid action. Urea 58-62 interleukin 1 beta Rattus norvegicus 28-46 8203649-4 1994 Indomethacin significantly reduced the pyrogenic effects of intracerebroventricular injections of LPS and IL-1 beta but not responses to IL-8, suggesting that pyrogenic responses to IL-8 were mediated independently of prostaglandins. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 106-115 7959906-0 1994 Effects of 1,25-dihydroxyvitamin D3 and the analogues MC903 and KH1060 on interleukin-1 beta-induced inhibition of rat pancreatic islet beta-cell function in vitro. KH 1060 64-70 interleukin 1 beta Rattus norvegicus 74-92 7959906-4 1994 All three vitamin D derivatives counteracted the suppressive effect of IL-1 beta on medium insulin accumulation, 1,25-(OH)2D3 being active at concentrations down to 0.1 nM, i.e., 1-2 orders of magnitude more efficacious than the analogues. Vitamin D 10-19 interleukin 1 beta Rattus norvegicus 71-80 7959906-4 1994 All three vitamin D derivatives counteracted the suppressive effect of IL-1 beta on medium insulin accumulation, 1,25-(OH)2D3 being active at concentrations down to 0.1 nM, i.e., 1-2 orders of magnitude more efficacious than the analogues. Calcitriol 113-125 interleukin 1 beta Rattus norvegicus 71-80 7959906-5 1994 However, only KH1060 opposed the suppressive effect of IL-1 beta on islet glucose-stimulated insulin secretion and glucose oxidation rate despite the fact that KH1060 itself reduced the islet DNA and insulin content by approximately 10% and 30%, respectively. Glucose 74-81 interleukin 1 beta Rattus norvegicus 55-64 7959906-6 1994 The protective effect observed against IL-1 beta-induced beta-cell dysfunction might be related to a beneficial action of vitamin D3 on the mitochondrial calcium metabolism of the beta-cells. Cholecalciferol 122-132 interleukin 1 beta Rattus norvegicus 39-48 7959906-6 1994 The protective effect observed against IL-1 beta-induced beta-cell dysfunction might be related to a beneficial action of vitamin D3 on the mitochondrial calcium metabolism of the beta-cells. Calcium 154-161 interleukin 1 beta Rattus norvegicus 39-48 7926271-6 1994 Islets cultured at 11 mmol/l glucose in the presence of 40 U/ml of interleukin-1 beta, showed a 63% decrease (P < 0.005) in enzyme activity compared with those cultured at 11 mmol/l glucose alone, and similar decreases were noted on analysis of glutamate decarboxylase biosynthesis and mRNA. Glucose 29-36 interleukin 1 beta Rattus norvegicus 67-85 7926271-6 1994 Islets cultured at 11 mmol/l glucose in the presence of 40 U/ml of interleukin-1 beta, showed a 63% decrease (P < 0.005) in enzyme activity compared with those cultured at 11 mmol/l glucose alone, and similar decreases were noted on analysis of glutamate decarboxylase biosynthesis and mRNA. Glucose 185-192 interleukin 1 beta Rattus norvegicus 67-85 7912003-0 1994 IL-1 beta-stimulated leucocyte-endothelial adhesion is regulated, in part, by the cyclic-GMP-dependent signal transduction pathway. Cyclic GMP 82-92 interleukin 1 beta Rattus norvegicus 0-9 7912003-2 1994 Using rat heart endothelial cells we found that exposure of endothelial cells to IL-1 beta (100 U/ml) induces a 133-fold increase in the intracellular concentration of cyclic-GMP; from 11.5 +/- 0.2 fM to 1530 +/- 117.8 fM (per 10(6) cells). Cyclic GMP 168-178 interleukin 1 beta Rattus norvegicus 81-90 7912003-4 1994 Cyclic-GMP analogue, dibutyryl cyclic-GMP Methylene blue, an inhibitor of guanylate cyclaese, and KT5823, a specific inhibitor of cyclic-GMP-dependent protein kinase, inhibited both basal as well as IL-1 beta-induced endothelial cell adhesiveness for leucocytes, and KT5823 abolished the dibutyryl-cyclic-GMP-induced increase in endothelial adhesiveness. Cyclic GMP 0-10 interleukin 1 beta Rattus norvegicus 199-208 7912003-4 1994 Cyclic-GMP analogue, dibutyryl cyclic-GMP Methylene blue, an inhibitor of guanylate cyclaese, and KT5823, a specific inhibitor of cyclic-GMP-dependent protein kinase, inhibited both basal as well as IL-1 beta-induced endothelial cell adhesiveness for leucocytes, and KT5823 abolished the dibutyryl-cyclic-GMP-induced increase in endothelial adhesiveness. dibutyryl cyclic-gmp methylene blue 21-56 interleukin 1 beta Rattus norvegicus 199-208 7912003-4 1994 Cyclic-GMP analogue, dibutyryl cyclic-GMP Methylene blue, an inhibitor of guanylate cyclaese, and KT5823, a specific inhibitor of cyclic-GMP-dependent protein kinase, inhibited both basal as well as IL-1 beta-induced endothelial cell adhesiveness for leucocytes, and KT5823 abolished the dibutyryl-cyclic-GMP-induced increase in endothelial adhesiveness. KT 5823 98-104 interleukin 1 beta Rattus norvegicus 199-208 7912003-5 1994 The effect of cyclic-GMP, induced by IL-1 beta treatment, on the endothelial adhesiveness may be either direct or indirect because of the time-gap between the rise in cyclic-GMP level and the increase of endothelial adhesiveness. Cyclic GMP 14-24 interleukin 1 beta Rattus norvegicus 37-46 7912003-5 1994 The effect of cyclic-GMP, induced by IL-1 beta treatment, on the endothelial adhesiveness may be either direct or indirect because of the time-gap between the rise in cyclic-GMP level and the increase of endothelial adhesiveness. Cyclic GMP 167-177 interleukin 1 beta Rattus norvegicus 37-46 7912003-7 1994 However, the fact that KT5823 failed to prevent this increase, suggests that, although the IL-1 beta-induced increase in adhesiveness is caused by the increase in intracellular levels of cyclic-GMP, it may not be mediated through intercellular adhesion molecule-1. Cyclic GMP 187-197 interleukin 1 beta Rattus norvegicus 91-100 7514175-5 1994 We investigated whether dexamethasone and transforming growth factor-beta 1 (TGF-beta 1) suppress iNOS mRNA after its induction by IL-1 beta. Dexamethasone 24-37 interleukin 1 beta Rattus norvegicus 131-140 7514175-7 1994 IL-1 beta promoted a dramatic and prolonged induction of RASMC iNOS mRNA that peaked at 48 h. Dexamethasone prevented this induction of iNOS mRNA only when given before the addition of IL-1 beta. Dexamethasone 94-107 interleukin 1 beta Rattus norvegicus 185-194 8194694-1 1994 BACKGROUND/AIMS: Interleukin 1 beta (IL-1 beta) is known to regulate intestinal ion and water transport in vitro through prostaglandin release. Water 88-93 interleukin 1 beta Rattus norvegicus 17-35 8194694-1 1994 BACKGROUND/AIMS: Interleukin 1 beta (IL-1 beta) is known to regulate intestinal ion and water transport in vitro through prostaglandin release. Water 88-93 interleukin 1 beta Rattus norvegicus 37-46 8194694-1 1994 BACKGROUND/AIMS: Interleukin 1 beta (IL-1 beta) is known to regulate intestinal ion and water transport in vitro through prostaglandin release. prostaglandin release 121-142 interleukin 1 beta Rattus norvegicus 17-35 8194694-1 1994 BACKGROUND/AIMS: Interleukin 1 beta (IL-1 beta) is known to regulate intestinal ion and water transport in vitro through prostaglandin release. prostaglandin release 121-142 interleukin 1 beta Rattus norvegicus 37-46 8194694-2 1994 This study investigated the effect of IL-1 beta on colonic net water flux in vivo to determine its nature (nerve mediation versus action on the epithelium), the mediators involved, and its relationship with mast cell degranulation. Water 63-68 interleukin 1 beta Rattus norvegicus 38-47 8194694-10 1994 A23187 or IL-1 beta increased histamine levels in the effluent during 75 and 45 minutes, respectively. Histamine 30-39 interleukin 1 beta Rattus norvegicus 10-19 8194703-0 1994 Interleukin 1 beta inhibits gastric emptying in rats: mediation through prostaglandin and corticotropin-releasing factor. Prostaglandins 72-85 interleukin 1 beta Rattus norvegicus 0-18 8194703-1 1994 BACKGROUND/AIMS: Interleukin 1 beta (IL-1 beta) increases the release of corticotropin-releasing factor (CRF) in the brain through prostaglandin pathways. Prostaglandins 131-144 interleukin 1 beta Rattus norvegicus 17-35 8194703-1 1994 BACKGROUND/AIMS: Interleukin 1 beta (IL-1 beta) increases the release of corticotropin-releasing factor (CRF) in the brain through prostaglandin pathways. Prostaglandins 131-144 interleukin 1 beta Rattus norvegicus 37-46 8194703-7 1994 Indomethacin (5 mg/kg, intraperitoneally) completely prevented the 61% inhibition induced by intracisternal IL-1 beta (0.1 ng) but had no effect on CRF-induced (600 ng) 72% inhibition of gastric emptying. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 108-117 8194703-10 1994 CONCLUSIONS: IL-1 beta acts in the brain to induce a long-lasting inhibition of gastric emptying; IL-1 beta action is mediated through central IL-1 receptors and prostaglandin- and CRF-dependent mechanisms. Prostaglandins 162-175 interleukin 1 beta Rattus norvegicus 13-22 8194703-10 1994 CONCLUSIONS: IL-1 beta acts in the brain to induce a long-lasting inhibition of gastric emptying; IL-1 beta action is mediated through central IL-1 receptors and prostaglandin- and CRF-dependent mechanisms. Prostaglandins 162-175 interleukin 1 beta Rattus norvegicus 98-107 7817387-10 1994 These results suggest that IL-1 beta affects the release of AVP and ACTH, blood pressure and thermogenesis via prostaglandins (PGs), but ANH release related to IL-1 beta may not be mediated by PGs. Prostaglandins 111-125 interleukin 1 beta Rattus norvegicus 27-36 7817387-10 1994 These results suggest that IL-1 beta affects the release of AVP and ACTH, blood pressure and thermogenesis via prostaglandins (PGs), but ANH release related to IL-1 beta may not be mediated by PGs. Prostaglandins 127-130 interleukin 1 beta Rattus norvegicus 27-36 7942328-8 1994 After pretreatment with the immunoadjuvant, zymosan, the IL-1 beta fevers were enhanced to equal those induced by PGE. Zymosan 44-51 interleukin 1 beta Rattus norvegicus 57-66 7942328-10 1994 IL-1 beta raised body temperature by 1.20 +/- 0.10 degrees C. An increased dose of dipyrone (50 mg/kg, i.v.) Dipyrone 83-91 interleukin 1 beta Rattus norvegicus 0-9 8203649-5 1994 In contrast, dexamethasone markedly attenuated pyrogenic responses to IL-8 and IL-1 beta. Dexamethasone 13-26 interleukin 1 beta Rattus norvegicus 79-88 7518300-15 1994 Combination of Bt2 cyclic AMP and IL-1 beta or TNF alpha revealed a strong synergy in terms of nitrite formation. Nitrites 95-102 interleukin 1 beta Rattus norvegicus 34-43 7518300-16 1994 Time-course studies indicated that cyclic AMP needed to be increased during the whole period of IL-1 Beta stimulation for maximal nitrite production.7. Cyclic AMP 35-45 interleukin 1 beta Rattus norvegicus 96-105 7514363-3 1994 NO synthase mRNA appeared after 4-h exposure to interleukin-1 beta (IL-1 beta), and levels continued to increase up to 24 h. Levels of NO synthase transcripts were greatest in VSMC treated with IL-1 beta (1 nM), lower in VSMC treated with Escherichia coli lipopolysaccharide (LPS; 100 micrograms/ml), and just detectable in VSMC treated with tumor necrosis factor-alpha (TNF-alpha; 1 nM). vsmc 176-180 interleukin 1 beta Rattus norvegicus 68-77 7518300-16 1994 Time-course studies indicated that cyclic AMP needed to be increased during the whole period of IL-1 Beta stimulation for maximal nitrite production.7. Nitrites 130-137 interleukin 1 beta Rattus norvegicus 96-105 7518300-17 1994 These observations suggest that cyclic AMP controls NO synthase expression in mesangial cells.Furthermore, the signalling cascades triggered by IL-1 Beta and TNF alpha synergize with the cyclic AMP pathway to stimulate NO synthase activity. Cyclic AMP 32-42 interleukin 1 beta Rattus norvegicus 144-153 7518300-17 1994 These observations suggest that cyclic AMP controls NO synthase expression in mesangial cells.Furthermore, the signalling cascades triggered by IL-1 Beta and TNF alpha synergize with the cyclic AMP pathway to stimulate NO synthase activity. Cyclic AMP 187-197 interleukin 1 beta Rattus norvegicus 144-153 8178348-0 1994 The role of nitric oxide in IL-1 beta-mediated dysfunction of rodent islets of Langerhans. Nitric Oxide 12-24 interleukin 1 beta Rattus norvegicus 28-37 8178348-5 1994 Nitrite levels in the medium (indirect measure of NO) after islets were cultured for a 24-hr period were nearly 3-fold greater in IL-1 beta-exposed islets than control islet cultures (5.8 +/- 1.0 microM vs. 2.2 +/- 0.3 microM, P = 0.03). Nitrites 0-7 interleukin 1 beta Rattus norvegicus 130-139 8178348-6 1994 Production of nitrite by islet cells in the presence of IL-1 beta was inhibited in cultures also containing 2 mM L-NG-monomethyl-Arginine (L-NMMA) (3.4 +/- 0.4 microM, n = 9, P = 0.09 vs. control). Nitrites 14-21 interleukin 1 beta Rattus norvegicus 56-65 8178348-6 1994 Production of nitrite by islet cells in the presence of IL-1 beta was inhibited in cultures also containing 2 mM L-NG-monomethyl-Arginine (L-NMMA) (3.4 +/- 0.4 microM, n = 9, P = 0.09 vs. control). omega-N-Methylarginine 139-145 interleukin 1 beta Rattus norvegicus 56-65 8178348-8 1994 Addition of 2 mM L-NMMA to islet cultures in the presence of IL-1 beta (20 IU/ml) (n = 9) restored insulin release to normal (from 6 +/- 2 to 38 +/- 9 microU, P > or = 0.6), suggesting that NO mediates the inhibitory effect of IL-1 beta on beta-cell function. omega-N-Methylarginine 17-23 interleukin 1 beta Rattus norvegicus 61-70 8178348-8 1994 Addition of 2 mM L-NMMA to islet cultures in the presence of IL-1 beta (20 IU/ml) (n = 9) restored insulin release to normal (from 6 +/- 2 to 38 +/- 9 microU, P > or = 0.6), suggesting that NO mediates the inhibitory effect of IL-1 beta on beta-cell function. omega-N-Methylarginine 17-23 interleukin 1 beta Rattus norvegicus 230-239 7513157-0 1994 Pyrrolidine dithiocarbamate differentially affects interleukin 1 beta- and cAMP-induced nitric oxide synthase expression in rat renal mesangial cells. pyrrolidine dithiocarbamic acid 0-27 interleukin 1 beta Rattus norvegicus 51-69 7513157-3 1994 We have used pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF kappa B), to determine its role in IL-1 beta- and cAMP-triggered NOS expression. pyrrolidine dithiocarbamic acid 13-40 interleukin 1 beta Rattus norvegicus 133-142 7513157-3 1994 We have used pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF kappa B), to determine its role in IL-1 beta- and cAMP-triggered NOS expression. pyrrolidine dithiocarbamic acid 42-46 interleukin 1 beta Rattus norvegicus 133-142 7802762-7 1994 A mixture of LPS and the cytokines gamma-interferon, interleukin-1 beta, and tumor necrosis factor-alpha increased steady-state levels of mRNA of GTP-cyclohydrolase-I (GTP-CH), the rate-limiting enzyme in BH4 biosynthesis. sapropterin 205-208 interleukin 1 beta Rattus norvegicus 53-104 7514363-3 1994 NO synthase mRNA appeared after 4-h exposure to interleukin-1 beta (IL-1 beta), and levels continued to increase up to 24 h. Levels of NO synthase transcripts were greatest in VSMC treated with IL-1 beta (1 nM), lower in VSMC treated with Escherichia coli lipopolysaccharide (LPS; 100 micrograms/ml), and just detectable in VSMC treated with tumor necrosis factor-alpha (TNF-alpha; 1 nM). vsmc 176-180 interleukin 1 beta Rattus norvegicus 194-203 7514363-3 1994 NO synthase mRNA appeared after 4-h exposure to interleukin-1 beta (IL-1 beta), and levels continued to increase up to 24 h. Levels of NO synthase transcripts were greatest in VSMC treated with IL-1 beta (1 nM), lower in VSMC treated with Escherichia coli lipopolysaccharide (LPS; 100 micrograms/ml), and just detectable in VSMC treated with tumor necrosis factor-alpha (TNF-alpha; 1 nM). vsmc 221-225 interleukin 1 beta Rattus norvegicus 194-203 7514363-4 1994 IL-1 beta, TNF-alpha, and LPS each induced NO synthase activity, assessed by release of nitrite, conversion of L-arginine to L-citrulline, and increased levels of guanosine 3",5"-cyclic monophosphate, whereas IL-2, IL-6, and interferon-gamma were ineffective. Nitrites 88-95 interleukin 1 beta Rattus norvegicus 0-9 7514363-4 1994 IL-1 beta, TNF-alpha, and LPS each induced NO synthase activity, assessed by release of nitrite, conversion of L-arginine to L-citrulline, and increased levels of guanosine 3",5"-cyclic monophosphate, whereas IL-2, IL-6, and interferon-gamma were ineffective. Arginine 111-121 interleukin 1 beta Rattus norvegicus 0-9 7514363-4 1994 IL-1 beta, TNF-alpha, and LPS each induced NO synthase activity, assessed by release of nitrite, conversion of L-arginine to L-citrulline, and increased levels of guanosine 3",5"-cyclic monophosphate, whereas IL-2, IL-6, and interferon-gamma were ineffective. Citrulline 125-137 interleukin 1 beta Rattus norvegicus 0-9 7514363-4 1994 IL-1 beta, TNF-alpha, and LPS each induced NO synthase activity, assessed by release of nitrite, conversion of L-arginine to L-citrulline, and increased levels of guanosine 3",5"-cyclic monophosphate, whereas IL-2, IL-6, and interferon-gamma were ineffective. Cyclic GMP 163-199 interleukin 1 beta Rattus norvegicus 0-9 8142651-2 1994 Experiments were performed to examine the effect of the releasate from activated platelets on the production of nitric oxide from interleukin-1 beta (IL-1 beta)-treated cultured rat aortic smooth muscle cells. Nitric Oxide 112-124 interleukin 1 beta Rattus norvegicus 130-148 7910873-13 1994 CONCLUSIONS: There is a temporal association in the expression of IL-1 beta, TNF alpha, MCP-1, and IL-6 with the upregulation of intercellular adhesion molecule-1 and leukocyte infiltration within the tubulointerstitium in anti-TBM antibody-associated TIN. metsulfuron methyl 228-231 interleukin 1 beta Rattus norvegicus 66-75 8142651-2 1994 Experiments were performed to examine the effect of the releasate from activated platelets on the production of nitric oxide from interleukin-1 beta (IL-1 beta)-treated cultured rat aortic smooth muscle cells. Nitric Oxide 112-124 interleukin 1 beta Rattus norvegicus 150-159 8064164-6 1994 RESULTS: The formation of nitrite and cGMP was significantly increased after incubation of mesangial cells with interleukin-1 beta or lipopolysaccharide. Nitrites 26-33 interleukin 1 beta Rattus norvegicus 112-130 8064164-6 1994 RESULTS: The formation of nitrite and cGMP was significantly increased after incubation of mesangial cells with interleukin-1 beta or lipopolysaccharide. Cyclic GMP 38-42 interleukin 1 beta Rattus norvegicus 112-130 8064164-15 1994 CONCLUSIONS: The present findings support recent observations that interleukin-1 beta and lipopolysaccharide strongly induce NO production in mesangial cells, as is shown indirectly by the greatly increased formation of nitrite and cGMP. Nitrites 220-227 interleukin 1 beta Rattus norvegicus 67-85 8064164-15 1994 CONCLUSIONS: The present findings support recent observations that interleukin-1 beta and lipopolysaccharide strongly induce NO production in mesangial cells, as is shown indirectly by the greatly increased formation of nitrite and cGMP. Cyclic GMP 232-236 interleukin 1 beta Rattus norvegicus 67-85 8019746-0 1994 Interleukin-1 beta enhances capsaicin-induced neurogenic vasodilatation in the rat skin. Capsaicin 28-37 interleukin 1 beta Rattus norvegicus 0-18 8049716-8 1994 These stimulatory effects of IL-1 beta and IL-6 were blocked by cyclo-oxygenase inhibitors, indomethacin (28 microM) and ibuprofen (100 nM), but not by the lipoxygenase inhibitor, BW A4C (10 micrograms/ml), suggesting that prostaglandins are involved in this process. Ibuprofen 121-130 interleukin 1 beta Rattus norvegicus 29-38 8049716-8 1994 These stimulatory effects of IL-1 beta and IL-6 were blocked by cyclo-oxygenase inhibitors, indomethacin (28 microM) and ibuprofen (100 nM), but not by the lipoxygenase inhibitor, BW A4C (10 micrograms/ml), suggesting that prostaglandins are involved in this process. Prostaglandins 223-237 interleukin 1 beta Rattus norvegicus 29-38 8158253-0 1994 In the rat, endogenous nitric oxide modulates the response of the hypothalamic-pituitary-adrenal axis to interleukin-1 beta, vasopressin, and oxytocin. Nitric Oxide 23-35 interleukin 1 beta Rattus norvegicus 105-123 8202220-4 1994 Chronic replacement with moderate doses of corticosterone restored the fever response in adrenalectomized animals in response to icv administration of IL-1 beta but only partially reversed the fever caused by IL-6. Corticosterone 43-57 interleukin 1 beta Rattus norvegicus 151-160 8202220-6 1994 In intact animals corticosterone blocked the fever response to icv injected IL-1 beta. Corticosterone 18-32 interleukin 1 beta Rattus norvegicus 76-85 8003768-0 1994 An interleukin-1 beta-induced noradrenaline release in the spleen is mediated by brain corticotropin-releasing factor: an in vivo microdialysis study in conscious rats. Norepinephrine 30-43 interleukin 1 beta Rattus norvegicus 3-21 8003768-1 1994 The purpose of this study was to investigate whether an intraperitoneal injection of interleukin-1 beta (IL-1 beta) affects noradrenaline release in the spleen through its action on the brain of conscious rats. Norepinephrine 124-137 interleukin 1 beta Rattus norvegicus 85-103 8003768-1 1994 The purpose of this study was to investigate whether an intraperitoneal injection of interleukin-1 beta (IL-1 beta) affects noradrenaline release in the spleen through its action on the brain of conscious rats. Norepinephrine 124-137 interleukin 1 beta Rattus norvegicus 105-114 8003768-5 1994 The intraperitoneal injection of IL-1 beta (100 ng/kg) produced an immediate and significant increase in the noradrenaline levels in the spleen. Norepinephrine 109-122 interleukin 1 beta Rattus norvegicus 33-42 8003768-7 1994 An intracerebroventricular (ICV) injection of a corticotropin-releasing factor (CRF) antagonist (alpha-helical CRF9-41, 30 micrograms) significantly attenuated the IL-1 beta-induced increase in the noradrenaline release. Norepinephrine 198-211 interleukin 1 beta Rattus norvegicus 164-173 8003768-9 1994 These results suggest that the intraperitoneal injection of IL-1 beta facilitates noradrenaline release in the spleen through activation of the sympathetic nerve, and the increased sympathetic activity is, at least in part, due to the excitation of neurons containing CRF in the brain. Norepinephrine 82-95 interleukin 1 beta Rattus norvegicus 60-69 8049716-8 1994 These stimulatory effects of IL-1 beta and IL-6 were blocked by cyclo-oxygenase inhibitors, indomethacin (28 microM) and ibuprofen (100 nM), but not by the lipoxygenase inhibitor, BW A4C (10 micrograms/ml), suggesting that prostaglandins are involved in this process. Indomethacin 92-104 interleukin 1 beta Rattus norvegicus 29-38 8145021-0 1994 Regulation of hepatic endothelial cell and macrophage proliferation and nitric oxide production by GM-CSF, M-CSF, and IL-1 beta following acute endotoxemia. Nitric Oxide 72-84 interleukin 1 beta Rattus norvegicus 118-127 8145021-12 1994 Interestingly, in both endothelial cells and macrophages from endotoxemic rats, GM-CSF, M-CSF, and IL-1 beta synergized with LPS and IFN-gamma to induce nitric oxide production. Nitric Oxide 153-165 interleukin 1 beta Rattus norvegicus 99-108 8154043-9 1994 In addition, RPM treatment prevented intragraft production of the proinflammatory cytokines IL-1 beta, IL-6, and IL-8. Sirolimus 13-16 interleukin 1 beta Rattus norvegicus 92-101 8019746-2 1994 This study examined the effect of interleukin-1 beta (IL-1 beta) on the capsaicin-induced increase in cutaneous blood flow of anaesthetized rats as measured by laser Doppler flowmetry. Capsaicin 72-81 interleukin 1 beta Rattus norvegicus 34-52 8019746-2 1994 This study examined the effect of interleukin-1 beta (IL-1 beta) on the capsaicin-induced increase in cutaneous blood flow of anaesthetized rats as measured by laser Doppler flowmetry. Capsaicin 72-81 interleukin 1 beta Rattus norvegicus 54-63 8019746-6 1994 IL-1 beta (0.5-500 pg) was without effect on blood flow on its own but dose-dependently enhanced the hyperaemic response to intraplantar capsaicin (0.3 microgram) up to 180% (P < 0.05) of the response seen in saline-treated paws. Capsaicin 137-146 interleukin 1 beta Rattus norvegicus 0-9 8019746-11 1994 did not alter the capsaicin-induced vasodilatation but prevented IL-1 beta (50 pg) from augmenting the hyperaemic response to capsaicin. Capsaicin 126-135 interleukin 1 beta Rattus norvegicus 65-74 8019746-15 1994 These data indicate that IL-1 beta enhances the cutaneous hyperaemic response to afferent nerve stimulation with capsaicin in a prostaglandin-dependent manner. Capsaicin 113-122 interleukin 1 beta Rattus norvegicus 25-34 8019746-15 1994 These data indicate that IL-1 beta enhances the cutaneous hyperaemic response to afferent nerve stimulation with capsaicin in a prostaglandin-dependent manner. Prostaglandins 128-141 interleukin 1 beta Rattus norvegicus 25-34 7521274-5 1994 Both CsA and FK506 (at 1 mumol/L) significantly inhibited nitrite production induced by recombinant murine interleukin-1 beta (rIL-1 beta). Tacrolimus 13-18 interleukin 1 beta Rattus norvegicus 127-137 7521274-5 1994 Both CsA and FK506 (at 1 mumol/L) significantly inhibited nitrite production induced by recombinant murine interleukin-1 beta (rIL-1 beta). Nitrites 58-65 interleukin 1 beta Rattus norvegicus 127-137 7521274-5 1994 Both CsA and FK506 (at 1 mumol/L) significantly inhibited nitrite production induced by recombinant murine interleukin-1 beta (rIL-1 beta). Cyclosporine 5-8 interleukin 1 beta Rattus norvegicus 127-137 8162947-4 1994 Interleukin-1 beta- and TNF-induced gastric relaxations were concentration dependently inhibited by BW 755c, which inhibits both cyclooxygenase and lipoxygenase, BW A4, which selectively inhibits the 5-lipoxygenase pathway, and SC 41930, a selective leukotriene B4 receptor antagonist, providing pharmacological evidence that leukotriene B4 is involved in the relaxant effects of both cytokines. Leukotriene B4 250-264 interleukin 1 beta Rattus norvegicus 0-18 8119136-4 1994 Also, the cytokine combination of IL-1 beta, tumor necrosis factor-alpha, and interferon-gamma induced a 10-fold increase in NO production by RIN cells, and L-NG-monomethyl arginine, an inhibitor of NO synthase, produced a dose-dependent inhibition of cytokine-induced NO production, DNA fragmentation, and cell destruction. omega-N-Methylarginine 157-181 interleukin 1 beta Rattus norvegicus 34-43 8189386-5 1994 The present results showed that the capsaicin desensitized rats had significantly smaller increases in plasma ACTH than the control rats in response to intravenous injection of IL-1 beta or prostaglandin E2. Capsaicin 36-45 interleukin 1 beta Rattus norvegicus 177-186 7915872-0 1994 Effects of flezelastine and its enantiomers on LPS-induced IL-1 beta generation in vitro and LPS-induced pyrexia in vivo. flezelastine 11-23 interleukin 1 beta Rattus norvegicus 59-68 7915872-3 1994 In vivo, LPS-induced fever in rats, which is at least partly driven by the release of IL-1 beta, was also inhibited by flezelastine. flezelastine 119-131 interleukin 1 beta Rattus norvegicus 86-95 8079811-0 1994 Calcium overload toxicity and functional impairment in peritoneal leukocytes elicited by glycogen or interleukin-1 beta. Calcium 0-7 interleukin 1 beta Rattus norvegicus 101-119 8079811-4 1994 Peritoneal administration of IL-1 beta caused elicitation of cells which were enriched in eosinophils; however, the functional responses of the cells in all three groups were broadly similar in terms of the ability of the agonists FMLP, PMA and A23187 to initiate superoxide generation, beta-glucuronidase secretion and leukotriene generation. Tetradecanoylphorbol Acetate 237-240 interleukin 1 beta Rattus norvegicus 29-38 8079811-4 1994 Peritoneal administration of IL-1 beta caused elicitation of cells which were enriched in eosinophils; however, the functional responses of the cells in all three groups were broadly similar in terms of the ability of the agonists FMLP, PMA and A23187 to initiate superoxide generation, beta-glucuronidase secretion and leukotriene generation. Calcimycin 245-251 interleukin 1 beta Rattus norvegicus 29-38 8079811-4 1994 Peritoneal administration of IL-1 beta caused elicitation of cells which were enriched in eosinophils; however, the functional responses of the cells in all three groups were broadly similar in terms of the ability of the agonists FMLP, PMA and A23187 to initiate superoxide generation, beta-glucuronidase secretion and leukotriene generation. Superoxides 264-274 interleukin 1 beta Rattus norvegicus 29-38 8079811-4 1994 Peritoneal administration of IL-1 beta caused elicitation of cells which were enriched in eosinophils; however, the functional responses of the cells in all three groups were broadly similar in terms of the ability of the agonists FMLP, PMA and A23187 to initiate superoxide generation, beta-glucuronidase secretion and leukotriene generation. Leukotrienes 320-331 interleukin 1 beta Rattus norvegicus 29-38 8304483-0 1994 Regulation of prostaglandin endoperoxide synthase gene expression in rat mesangial cells by interleukin-1 beta. Prostaglandins 14-27 interleukin 1 beta Rattus norvegicus 92-110 7507826-0 1994 Interrelationship of changes in islet nicotine adeninedinucleotide, insulin secretion, and cell viability induced by interleukin-1 beta. nicotine adeninedinucleotide 38-66 interleukin 1 beta Rattus norvegicus 117-135 7507826-3 1994 After overnight incubation of isolated rat islets with 15 U/ml IL-1 beta and 11 mM glucose, sequential hourly insulin secretory responses to the same glucose concentration, 22 mM glucose, and 22 mM glucose plus forskolin were severely inhibited to 10-37% of the control value. Colforsin 211-220 interleukin 1 beta Rattus norvegicus 63-72 7507826-4 1994 Islet NAD levels were also sharply reduced to 43% of the control value after 24-h exposure to IL-1 beta, but not after 1 or 3 h, demonstrating the same time course as that for inhibition of insulin secretion. NAD 6-9 interleukin 1 beta Rattus norvegicus 94-103 7507826-5 1994 Exposure to IL-1 beta also decreased islet cell viability measured as trypan blue exclusion. Trypan Blue 70-81 interleukin 1 beta Rattus norvegicus 12-21 7507826-6 1994 Only 1 mM N-methyl arginine, an inhibitor of nitric oxide synthase, completely protected all three parameters of beta-cell function from damage by IL-1 beta. omega-N-Methylarginine 10-27 interleukin 1 beta Rattus norvegicus 147-156 7507826-7 1994 Nicotinamide and thymidine prevented the IL-1 beta-induced loss of cell viability and suppression of NAD, but had no effect on sustaining insulin secretion. Niacinamide 0-12 interleukin 1 beta Rattus norvegicus 41-50 7507826-7 1994 Nicotinamide and thymidine prevented the IL-1 beta-induced loss of cell viability and suppression of NAD, but had no effect on sustaining insulin secretion. Thymidine 17-26 interleukin 1 beta Rattus norvegicus 41-50 7507826-7 1994 Nicotinamide and thymidine prevented the IL-1 beta-induced loss of cell viability and suppression of NAD, but had no effect on sustaining insulin secretion. NAD 101-104 interleukin 1 beta Rattus norvegicus 41-50 7507826-9 1994 Thus, the loss of the secretory response appears to be more narrowly restricted to nitric oxide radical damage induced by exposure to IL-1B. Nitric Oxide 83-95 interleukin 1 beta Rattus norvegicus 134-139 8293819-0 1994 Succinic acid monomethyl ester protects rat pancreatic islet secretory potential against interleukin-1 beta (IL-1 beta) without affecting glutamate decarboxylase expression or nitric oxide production. monomethyl succinate 0-30 interleukin 1 beta Rattus norvegicus 89-107 8293819-0 1994 Succinic acid monomethyl ester protects rat pancreatic islet secretory potential against interleukin-1 beta (IL-1 beta) without affecting glutamate decarboxylase expression or nitric oxide production. monomethyl succinate 0-30 interleukin 1 beta Rattus norvegicus 109-118 8293819-1 1994 Rat pancreatic islets exposed to interleukin-1 beta (IL-1 beta) in the presence of succinic acid monomethyl ester (SAM) have a higher insulin release in response to glucose and higher glucose oxidation rates, as compared to islets exposed to IL-1 beta alone. monomethyl succinate 83-113 interleukin 1 beta Rattus norvegicus 33-51 8293819-1 1994 Rat pancreatic islets exposed to interleukin-1 beta (IL-1 beta) in the presence of succinic acid monomethyl ester (SAM) have a higher insulin release in response to glucose and higher glucose oxidation rates, as compared to islets exposed to IL-1 beta alone. monomethyl succinate 83-113 interleukin 1 beta Rattus norvegicus 53-62 8293819-1 1994 Rat pancreatic islets exposed to interleukin-1 beta (IL-1 beta) in the presence of succinic acid monomethyl ester (SAM) have a higher insulin release in response to glucose and higher glucose oxidation rates, as compared to islets exposed to IL-1 beta alone. monomethyl succinate 115-118 interleukin 1 beta Rattus norvegicus 33-51 8293819-1 1994 Rat pancreatic islets exposed to interleukin-1 beta (IL-1 beta) in the presence of succinic acid monomethyl ester (SAM) have a higher insulin release in response to glucose and higher glucose oxidation rates, as compared to islets exposed to IL-1 beta alone. monomethyl succinate 115-118 interleukin 1 beta Rattus norvegicus 53-62 8293819-1 1994 Rat pancreatic islets exposed to interleukin-1 beta (IL-1 beta) in the presence of succinic acid monomethyl ester (SAM) have a higher insulin release in response to glucose and higher glucose oxidation rates, as compared to islets exposed to IL-1 beta alone. monomethyl succinate 115-118 interleukin 1 beta Rattus norvegicus 242-251 8293819-1 1994 Rat pancreatic islets exposed to interleukin-1 beta (IL-1 beta) in the presence of succinic acid monomethyl ester (SAM) have a higher insulin release in response to glucose and higher glucose oxidation rates, as compared to islets exposed to IL-1 beta alone. Glucose 165-172 interleukin 1 beta Rattus norvegicus 33-51 8293819-1 1994 Rat pancreatic islets exposed to interleukin-1 beta (IL-1 beta) in the presence of succinic acid monomethyl ester (SAM) have a higher insulin release in response to glucose and higher glucose oxidation rates, as compared to islets exposed to IL-1 beta alone. Glucose 165-172 interleukin 1 beta Rattus norvegicus 53-62 8293819-1 1994 Rat pancreatic islets exposed to interleukin-1 beta (IL-1 beta) in the presence of succinic acid monomethyl ester (SAM) have a higher insulin release in response to glucose and higher glucose oxidation rates, as compared to islets exposed to IL-1 beta alone. Glucose 184-191 interleukin 1 beta Rattus norvegicus 33-51 8293819-1 1994 Rat pancreatic islets exposed to interleukin-1 beta (IL-1 beta) in the presence of succinic acid monomethyl ester (SAM) have a higher insulin release in response to glucose and higher glucose oxidation rates, as compared to islets exposed to IL-1 beta alone. Glucose 184-191 interleukin 1 beta Rattus norvegicus 53-62 8110470-2 1994 By Northern blot analysis, TNF-alpha and MIP-2 mRNAs in total lung tissue increased markedly by 30 min and peaked by 1 h after LPS exposure, whereas expression of IL-1 beta and IL-6 was not detected until 1 h and peaked within 6 h. In contrast, neither RANTES nor TGF-beta 1 mRNA was induced by LPS throughout 72 h, although a basal expression was detected in both saline- and LPS-treated lung tissues. Sodium Chloride 365-371 interleukin 1 beta Rattus norvegicus 163-172 8032008-0 1994 A role for tyrosine kinase activation in interleukin-1 beta induced nitric oxide production in the insulin producing cell line RINm-5F. Nitric Oxide 68-80 interleukin 1 beta Rattus norvegicus 41-59 8032008-3 1994 It has been shown earlier that IL-1 beta will stimulate the production of nitrite in such cells. Nitrites 74-81 interleukin 1 beta Rattus norvegicus 31-40 8032008-5 1994 However, the tyrosine kinase antagonist tyrphostin inhibited, whereas sodium orthovanadate, okadaic acid and cyclosporin A, all inhibitors of protein phosphatases, potentiated IL-1 beta induced nitrite release to the medium. Tyrphostins 40-50 interleukin 1 beta Rattus norvegicus 176-185 8032008-5 1994 However, the tyrosine kinase antagonist tyrphostin inhibited, whereas sodium orthovanadate, okadaic acid and cyclosporin A, all inhibitors of protein phosphatases, potentiated IL-1 beta induced nitrite release to the medium. Sodium orthovanadate 70-90 interleukin 1 beta Rattus norvegicus 176-185 8032008-5 1994 However, the tyrosine kinase antagonist tyrphostin inhibited, whereas sodium orthovanadate, okadaic acid and cyclosporin A, all inhibitors of protein phosphatases, potentiated IL-1 beta induced nitrite release to the medium. Okadaic Acid 92-104 interleukin 1 beta Rattus norvegicus 176-185 8032008-5 1994 However, the tyrosine kinase antagonist tyrphostin inhibited, whereas sodium orthovanadate, okadaic acid and cyclosporin A, all inhibitors of protein phosphatases, potentiated IL-1 beta induced nitrite release to the medium. Cyclosporine 109-122 interleukin 1 beta Rattus norvegicus 176-185 8032008-5 1994 However, the tyrosine kinase antagonist tyrphostin inhibited, whereas sodium orthovanadate, okadaic acid and cyclosporin A, all inhibitors of protein phosphatases, potentiated IL-1 beta induced nitrite release to the medium. Nitrites 194-201 interleukin 1 beta Rattus norvegicus 176-185 8032008-6 1994 The tyrosine kinase antagonist genistein potentiated at a low concentration and inhibited at a high concentration the IL-1 beta effect. Genistein 31-40 interleukin 1 beta Rattus norvegicus 118-127 8120273-7 1994 We conclude that intratracheal administration of IL-1 beta induces the inflammatory changes, which are characterized by an increase in neutrophil counts in BALF, and increased AR to bradykinin, and that active sensitization per se does not potentiate the effect of IL-1 beta on AR to acetylcholine or bradykinin or on airway inflammation. Acetylcholine 284-297 interleukin 1 beta Rattus norvegicus 49-58 7506738-10 1994 These data suggest that although cAMP does activate astrocyte IL-6 gene expression, it is the PKC pathway that plays a primary role in the stimulation of astrocyte IL-6 gene expression by IL-1 beta and TNF-alpha. Cyclic AMP 33-37 interleukin 1 beta Rattus norvegicus 188-197 8304483-1 1994 In primary cultures of rat mesangial cells from passage 3 to 6, interleukin-1 beta (IL-1) induced a time-dependent increase in prostaglandin E2 (PGE2) formation and release into the extracellular medium. Dinoprostone 127-143 interleukin 1 beta Rattus norvegicus 64-82 8304483-1 1994 In primary cultures of rat mesangial cells from passage 3 to 6, interleukin-1 beta (IL-1) induced a time-dependent increase in prostaglandin E2 (PGE2) formation and release into the extracellular medium. Dinoprostone 145-149 interleukin 1 beta Rattus norvegicus 64-82 7922597-5 1994 These results suggest that IL-1 beta in the brain activates splenic sympathetic activity by its receptor-mediated and prostaglandin-dependent action that is sensitive to alpha-MSH, depending on CRF system. Prostaglandins 118-131 interleukin 1 beta Rattus norvegicus 27-36 8193934-7 1994 The results suggest that a small amount of IL-1 beta at the site of periodontal disease can induce fos-IR in brain neurons through increased prostaglandin production. Prostaglandins 141-154 interleukin 1 beta Rattus norvegicus 43-52 7850478-0 1994 Thermoregulation and hypothalamic histamine turnover modulated by interleukin-1 beta in rats. Histamine 34-43 interleukin 1 beta Rattus norvegicus 66-84 7505207-4 1994 IGF-I inhibited, in a concentration-dependent manner, the production of nitrite and L-citrulline evoked by IL-1 beta or TNF-alpha. Nitrites 72-79 interleukin 1 beta Rattus norvegicus 107-116 7505207-4 1994 IGF-I inhibited, in a concentration-dependent manner, the production of nitrite and L-citrulline evoked by IL-1 beta or TNF-alpha. Citrulline 84-96 interleukin 1 beta Rattus norvegicus 107-116 7505207-6 1994 Two IGF-I-related proteins, IGF-II and insulin, also inhibited, but to a smaller extent, the release of nitrite and the formation of L-citrulline stimulated by IL-1 beta. Nitrites 104-111 interleukin 1 beta Rattus norvegicus 160-169 7505207-6 1994 Two IGF-I-related proteins, IGF-II and insulin, also inhibited, but to a smaller extent, the release of nitrite and the formation of L-citrulline stimulated by IL-1 beta. Citrulline 133-145 interleukin 1 beta Rattus norvegicus 160-169 7505207-7 1994 Under bioassay conditions, the perfusates from columns containing IL-1 beta-treated smooth muscle cells relaxed rings of rat aorta without endothelium that had been contracted with phenylephrine; these relaxations were reversed by nitro-L-arginine. Phenylephrine 181-194 interleukin 1 beta Rattus norvegicus 66-75 7505207-7 1994 Under bioassay conditions, the perfusates from columns containing IL-1 beta-treated smooth muscle cells relaxed rings of rat aorta without endothelium that had been contracted with phenylephrine; these relaxations were reversed by nitro-L-arginine. Nitroarginine 231-247 interleukin 1 beta Rattus norvegicus 66-75 7505207-8 1994 Addition of IL-1 beta-treated vascular smooth muscle cells to indomethacin-treated platelets inhibited their aggregation to thrombin; methylene blue prevented this inhibition. Indomethacin 62-74 interleukin 1 beta Rattus norvegicus 12-21 7505207-8 1994 Addition of IL-1 beta-treated vascular smooth muscle cells to indomethacin-treated platelets inhibited their aggregation to thrombin; methylene blue prevented this inhibition. Methylene Blue 134-148 interleukin 1 beta Rattus norvegicus 12-21 7522298-1 1994 We investigated nitric oxide (NO) synthase activity in cultured neonatal rat cardiac myocytes and fibroblasts upon treatment with interleukin 1 beta (IL-1 beta) and lipopolysaccharide (LPS). Nitric Oxide 16-28 interleukin 1 beta Rattus norvegicus 130-148 8138745-2 1994 Certain of the biological effects of LPS may be mediated by cytokines such as interleukin-1 beta (IL-1 beta), while IL-1 beta itself may operate via induction of the prostaglandins and/or nerve growth factor (NGF). Prostaglandins 166-180 interleukin 1 beta Rattus norvegicus 116-125 8127005-3 1994 Exposure of serum-stimulated cells to IL-1 beta and IL-6 for 48 hours resulted in a dose-dependent inhibition of both mitogenesis, determined by 3H-thymidine incorporation, and proliferation, determined by absolute cell counts. Tritium 145-147 interleukin 1 beta Rattus norvegicus 38-47 8127005-3 1994 Exposure of serum-stimulated cells to IL-1 beta and IL-6 for 48 hours resulted in a dose-dependent inhibition of both mitogenesis, determined by 3H-thymidine incorporation, and proliferation, determined by absolute cell counts. Thymidine 148-157 interleukin 1 beta Rattus norvegicus 38-47 8127005-4 1994 Both IL-1 beta and IL-6 stimulated endogenous PGE2 production in this cell system. Dinoprostone 46-50 interleukin 1 beta Rattus norvegicus 5-14 8127005-5 1994 Cyclooxygenase inhibition by indomethacin and meclofenamate abrogated the inhibitory effects of both IL-1 beta and IL-6. Indomethacin 29-41 interleukin 1 beta Rattus norvegicus 101-110 8127005-5 1994 Cyclooxygenase inhibition by indomethacin and meclofenamate abrogated the inhibitory effects of both IL-1 beta and IL-6. Meclofenamic Acid 46-59 interleukin 1 beta Rattus norvegicus 101-110 8127005-7 1994 These results demonstrate that in serum-stimulated mesangial cells, both IL-1 beta and IL-6 inhibit mitogenesis and proliferation, and that these effects are mediated, in part, by stimulated endogenous prostaglandin production. Prostaglandins 202-215 interleukin 1 beta Rattus norvegicus 73-82 8295488-3 1994 Saline-infused rats were fed the amount of food consumed by their respective pair in the IL-1 beta group on the previous day. Sodium Chloride 0-6 interleukin 1 beta Rattus norvegicus 89-98 8295488-5 1994 IL-1 beta infusion resulted in fasting hypoglycemia as well as elevated blood glucose levels in response to an oral glucose load compared to controls. Glucose 78-85 interleukin 1 beta Rattus norvegicus 0-9 8295488-5 1994 IL-1 beta infusion resulted in fasting hypoglycemia as well as elevated blood glucose levels in response to an oral glucose load compared to controls. Glucose 116-123 interleukin 1 beta Rattus norvegicus 0-9 8132220-0 1994 In vitro modulation of interleukin-1 beta secretion by cultured rat doxorubicin-stimulated whole glomeruli and dissociated mesangial glomerular cells. Doxorubicin 68-79 interleukin 1 beta Rattus norvegicus 23-41 8132220-1 1994 Doxorubicin-stimulated whole rat glomeruli and dissociated mesangial and resident glomerular macrophage cells produced the release of interleukin (IL)-1 beta cytokine. Doxorubicin 0-11 interleukin 1 beta Rattus norvegicus 134-157 8132220-5 1994 These findings support the important role by both IL-1 beta and PAF-acether mediator factors, at the cellular level, in the rat model of doxorubicin-induced nephrosis. Doxorubicin 137-148 interleukin 1 beta Rattus norvegicus 50-59 7881019-0 1994 Involvement of endogenous nitric oxide in the inhibition by endotoxin and interleukin-1 beta of gastric acid secretion. Nitric Oxide 26-38 interleukin 1 beta Rattus norvegicus 74-92 7881019-2 1994 Likewise, acid secretion stimulated by the continuous intravenous perfusion of pentagastrin was inhibited by administration of interleukin-1 beta (IL-1 beta). Pentagastrin 79-91 interleukin 1 beta Rattus norvegicus 127-145 7881019-2 1994 Likewise, acid secretion stimulated by the continuous intravenous perfusion of pentagastrin was inhibited by administration of interleukin-1 beta (IL-1 beta). Pentagastrin 79-91 interleukin 1 beta Rattus norvegicus 147-156 7881019-7 1994 These observations suggest that the acute inhibition of acid responses to pentagastrin by endotoxin and IL-1 beta involves nitric oxide (NO) synthesis from L-arginine. Nitric Oxide 123-135 interleukin 1 beta Rattus norvegicus 104-113 7881019-7 1994 These observations suggest that the acute inhibition of acid responses to pentagastrin by endotoxin and IL-1 beta involves nitric oxide (NO) synthesis from L-arginine. Arginine 156-166 interleukin 1 beta Rattus norvegicus 104-113 7760523-4 1994 Pretreatment with intravenous indomethacin (1 mg/kg) markedly suppressed the increase in catecholamines induced by LPS and rIL-1 beta. Indomethacin 30-42 interleukin 1 beta Rattus norvegicus 123-133 7760523-4 1994 Pretreatment with intravenous indomethacin (1 mg/kg) markedly suppressed the increase in catecholamines induced by LPS and rIL-1 beta. Catecholamines 89-103 interleukin 1 beta Rattus norvegicus 123-133 7522298-1 1994 We investigated nitric oxide (NO) synthase activity in cultured neonatal rat cardiac myocytes and fibroblasts upon treatment with interleukin 1 beta (IL-1 beta) and lipopolysaccharide (LPS). Nitric Oxide 16-28 interleukin 1 beta Rattus norvegicus 150-159 7522298-2 1994 Incubation of cardiac myocytes for 24 h with IL-1 beta or LPS caused a significant increase in NO and cGMP production. Cyclic GMP 102-106 interleukin 1 beta Rattus norvegicus 45-54 7522298-3 1994 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine or transforming growth factor beta (TGF-beta) completely inhibited the IL-1 beta-induced NO and cGMP production in cardiac myocytes. omega-N-Methylarginine 42-66 interleukin 1 beta Rattus norvegicus 27-36 7522298-3 1994 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine or transforming growth factor beta (TGF-beta) completely inhibited the IL-1 beta-induced NO and cGMP production in cardiac myocytes. omega-N-Methylarginine 42-66 interleukin 1 beta Rattus norvegicus 138-147 7522298-3 1994 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine or transforming growth factor beta (TGF-beta) completely inhibited the IL-1 beta-induced NO and cGMP production in cardiac myocytes. Cyclic GMP 163-167 interleukin 1 beta Rattus norvegicus 27-36 7522298-3 1994 Simultaneous incubation of IL-1 beta with NG-monomethyl-L-arginine or transforming growth factor beta (TGF-beta) completely inhibited the IL-1 beta-induced NO and cGMP production in cardiac myocytes. Cyclic GMP 163-167 interleukin 1 beta Rattus norvegicus 138-147 8243260-9 1993 When compared to animals treated with the vehicle, rats infused with IL-1 beta showed a significant decrease in circulating LH concentrations, which was accompanied by lowered mRNA levels in the pituitary. Luteinizing Hormone 124-126 interleukin 1 beta Rattus norvegicus 69-78 7505613-0 1993 IL-1 beta induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: activation of cyclooxygenase by nitric oxide. Nitric Oxide 43-55 interleukin 1 beta Rattus norvegicus 0-9 7505613-3 1993 In vitro treatment of rat islets with the cytokine IL-1 beta results in an inhibition of glucose-stimulated insulin secretion that is mediated by the overproduction of nitric oxide. Glucose 89-96 interleukin 1 beta Rattus norvegicus 51-60 7505613-3 1993 In vitro treatment of rat islets with the cytokine IL-1 beta results in an inhibition of glucose-stimulated insulin secretion that is mediated by the overproduction of nitric oxide. Nitric Oxide 168-180 interleukin 1 beta Rattus norvegicus 51-60 7505613-4 1993 IL-1 beta also stimulates the production of the cyclooxygenase (COX) product prostaglandin E2 (PGE2). Dinoprostone 77-93 interleukin 1 beta Rattus norvegicus 0-9 7505613-4 1993 IL-1 beta also stimulates the production of the cyclooxygenase (COX) product prostaglandin E2 (PGE2). Dinoprostone 95-99 interleukin 1 beta Rattus norvegicus 0-9 7505613-6 1993 Treatment of rat islets with 5 units/mL IL-1 beta induces a similar time-dependent production of both nitrite and PGE2. Nitrites 102-109 interleukin 1 beta Rattus norvegicus 40-49 7505613-6 1993 Treatment of rat islets with 5 units/mL IL-1 beta induces a similar time-dependent production of both nitrite and PGE2. Dinoprostone 114-118 interleukin 1 beta Rattus norvegicus 40-49 7505613-7 1993 IL-1 beta-induced nitrite and PGE2 production is attenuated by the NOS inhibitor NG-monomethyl-L-arginine (NMMA), but NMMA has no inhibitory effect on the expression of either iCOX or iNOS as determined by immunoprecipitation. Nitrites 18-25 interleukin 1 beta Rattus norvegicus 0-9 7505613-7 1993 IL-1 beta-induced nitrite and PGE2 production is attenuated by the NOS inhibitor NG-monomethyl-L-arginine (NMMA), but NMMA has no inhibitory effect on the expression of either iCOX or iNOS as determined by immunoprecipitation. Dinoprostone 30-34 interleukin 1 beta Rattus norvegicus 0-9 7505613-7 1993 IL-1 beta-induced nitrite and PGE2 production is attenuated by the NOS inhibitor NG-monomethyl-L-arginine (NMMA), but NMMA has no inhibitory effect on the expression of either iCOX or iNOS as determined by immunoprecipitation. omega-N-Methylarginine 81-105 interleukin 1 beta Rattus norvegicus 0-9 7505613-7 1993 IL-1 beta-induced nitrite and PGE2 production is attenuated by the NOS inhibitor NG-monomethyl-L-arginine (NMMA), but NMMA has no inhibitory effect on the expression of either iCOX or iNOS as determined by immunoprecipitation. omega-N-Methylarginine 107-111 interleukin 1 beta Rattus norvegicus 0-9 7505613-8 1993 Actinomycin D prevents IL-1 beta-induced iCOX and iNOS expression and the production of both nitrite and PGE2 by islets, suggesting that mRNA transcription is required for IL-1 beta-induced expression of both iNOS and iCOX. Dactinomycin 0-13 interleukin 1 beta Rattus norvegicus 23-32 7505613-8 1993 Actinomycin D prevents IL-1 beta-induced iCOX and iNOS expression and the production of both nitrite and PGE2 by islets, suggesting that mRNA transcription is required for IL-1 beta-induced expression of both iNOS and iCOX. Dactinomycin 0-13 interleukin 1 beta Rattus norvegicus 172-181 7505613-8 1993 Actinomycin D prevents IL-1 beta-induced iCOX and iNOS expression and the production of both nitrite and PGE2 by islets, suggesting that mRNA transcription is required for IL-1 beta-induced expression of both iNOS and iCOX. Nitrites 93-100 interleukin 1 beta Rattus norvegicus 23-32 7505613-8 1993 Actinomycin D prevents IL-1 beta-induced iCOX and iNOS expression and the production of both nitrite and PGE2 by islets, suggesting that mRNA transcription is required for IL-1 beta-induced expression of both iNOS and iCOX. Nitrites 93-100 interleukin 1 beta Rattus norvegicus 172-181 7505613-8 1993 Actinomycin D prevents IL-1 beta-induced iCOX and iNOS expression and the production of both nitrite and PGE2 by islets, suggesting that mRNA transcription is required for IL-1 beta-induced expression of both iNOS and iCOX. Dinoprostone 105-109 interleukin 1 beta Rattus norvegicus 23-32 8243261-3 1993 The acute administration of interleukin-1 beta (IL-1 beta) into the brain ventricles of rats has been shown to cause a significant decrease in plasma LH levels, a phenomenon primarily mediated through inhibition of LHRH release. Luteinizing Hormone 150-152 interleukin 1 beta Rattus norvegicus 28-46 8243261-3 1993 The acute administration of interleukin-1 beta (IL-1 beta) into the brain ventricles of rats has been shown to cause a significant decrease in plasma LH levels, a phenomenon primarily mediated through inhibition of LHRH release. Luteinizing Hormone 150-152 interleukin 1 beta Rattus norvegicus 48-57 7504698-3 1993 We examined the role that the free radical nitric oxide plays in this process and report that IL-1 beta induces expression of the inducible isoform of nitric oxide synthase in ovarian cells as demonstrated by immunoprecipitation. Nitric Oxide 43-55 interleukin 1 beta Rattus norvegicus 94-103 7504698-4 1993 We show that IL-1 beta treatment results in the formation of nitric oxide (as measured by accumulation of nitrite and cGMP) in both a time- and concentration-dependent manner that is prevented by aminoguanidine, a selective inhibitor of the inducible isoform of nitric oxide synthase. Nitric Oxide 61-73 interleukin 1 beta Rattus norvegicus 13-22 7504698-4 1993 We show that IL-1 beta treatment results in the formation of nitric oxide (as measured by accumulation of nitrite and cGMP) in both a time- and concentration-dependent manner that is prevented by aminoguanidine, a selective inhibitor of the inducible isoform of nitric oxide synthase. Nitrites 106-113 interleukin 1 beta Rattus norvegicus 13-22 7504698-4 1993 We show that IL-1 beta treatment results in the formation of nitric oxide (as measured by accumulation of nitrite and cGMP) in both a time- and concentration-dependent manner that is prevented by aminoguanidine, a selective inhibitor of the inducible isoform of nitric oxide synthase. Cyclic GMP 118-122 interleukin 1 beta Rattus norvegicus 13-22 7504698-4 1993 We show that IL-1 beta treatment results in the formation of nitric oxide (as measured by accumulation of nitrite and cGMP) in both a time- and concentration-dependent manner that is prevented by aminoguanidine, a selective inhibitor of the inducible isoform of nitric oxide synthase. pimagedine 196-210 interleukin 1 beta Rattus norvegicus 13-22 7504472-1 1993 Induction of NO synthase expression by interleukin-1 beta in cultured vascular smooth muscle cells from rat aortas was accompanied by simultaneous induction of GTP: cyclohydrolase I. Guanosine Triphosphate 160-163 interleukin 1 beta Rattus norvegicus 39-57 7504472-3 1993 Inhibition of GTP: cyclohydrolase attenuated NO production by interleukin-1 beta-stimulated smooth muscle cells. Guanosine Triphosphate 14-17 interleukin 1 beta Rattus norvegicus 62-80 8404691-0 1993 Receptor-mediated stimulatory effect of IL-1 beta on hyaluronic acid and proteoglycan biosynthesis by cultured rat ovarian cells: role for heterologous cell-cell interactions. Hyaluronic Acid 53-68 interleukin 1 beta Rattus norvegicus 40-49 7691586-0 1993 Interleukin-1 beta (IL-1 beta) modulates prostaglandin production and the natural IL-1 receptor antagonist inhibits ovulation in the optimally stimulated rat ovarian perfusion model. Prostaglandins 41-54 interleukin 1 beta Rattus norvegicus 0-18 7691586-0 1993 Interleukin-1 beta (IL-1 beta) modulates prostaglandin production and the natural IL-1 receptor antagonist inhibits ovulation in the optimally stimulated rat ovarian perfusion model. Prostaglandins 41-54 interleukin 1 beta Rattus norvegicus 20-29 7691586-7 1993 IL-1 beta enhanced, in a dose- and gonadotropin-dependent fashion, the production of prostaglandin E2 (PGE2) in PMSG-stimulated ovaries with bursa removed given an ovulatory trigger of LH and IBMX compared to that in controls. Dinoprostone 85-101 interleukin 1 beta Rattus norvegicus 0-9 7691586-7 1993 IL-1 beta enhanced, in a dose- and gonadotropin-dependent fashion, the production of prostaglandin E2 (PGE2) in PMSG-stimulated ovaries with bursa removed given an ovulatory trigger of LH and IBMX compared to that in controls. Dinoprostone 103-107 interleukin 1 beta Rattus norvegicus 0-9 7691586-8 1993 PGF2 alpha and 6-keto-PGF1 alpha were also modulated by IL-1 beta. Dinoprost 0-4 interleukin 1 beta Rattus norvegicus 56-65 7691586-8 1993 PGF2 alpha and 6-keto-PGF1 alpha were also modulated by IL-1 beta. 6-keto-pgf1 15-26 interleukin 1 beta Rattus norvegicus 56-65 7691586-14 1993 IL-1 beta modulates PG, but not steroid, production. Prostaglandins 20-22 interleukin 1 beta Rattus norvegicus 0-9 8404691-5 1993 Treatment of whole ovarian dispersates with IL-1 beta (10 ng/ml) produced substantial increments in the accumulation of extracellular macromolecular material [11.5-, 2.9- and 2.6-fold for hyaluronic acid (HA), heparan sulfate (HS) and dermatan sulfate (DS) proteoglycans, respectively]. Hyaluronic Acid 188-203 interleukin 1 beta Rattus norvegicus 44-53 8224196-0 1993 Endogenous nitric oxide induced by interleukin-1 beta in rat islets of Langerhans and HIT-T15 cells causes significant DNA damage as measured by the "comet" assay. Nitric Oxide 11-23 interleukin 1 beta Rattus norvegicus 35-53 8406861-7 1993 The addition of CT with either IL-1 beta or tumor necrosis factor alpha gave even greater synergistic enhancement of IL-6 secretion, and dibutyryl cAMP could mimic CT"s synergy with IL-1 beta. Cyclic AMP 147-151 interleukin 1 beta Rattus norvegicus 182-191 8227364-6 1993 CGP 43182 markedly attenuates IL-1 beta- and TNF alpha-stimulated PGE2 synthesis in intact mesangial cells with IC50"s of 1.3 and 1.0 microM, respectively. Dinoprostone 66-70 interleukin 1 beta Rattus norvegicus 30-39 8247820-4 1993 Injection of meperidine blocked the onset of fever in rats injected with endotoxin and attenuated the febrile response in rats injected with IL-1 beta. Meperidine 13-23 interleukin 1 beta Rattus norvegicus 141-150 8247820-6 1993 These data suggest that meperidine decreases rigors and chills by decreasing the "set point" for fever, perhaps by reducing MNL secretion of IL-1 beta. Meperidine 24-34 interleukin 1 beta Rattus norvegicus 141-150 8404691-5 1993 Treatment of whole ovarian dispersates with IL-1 beta (10 ng/ml) produced substantial increments in the accumulation of extracellular macromolecular material [11.5-, 2.9- and 2.6-fold for hyaluronic acid (HA), heparan sulfate (HS) and dermatan sulfate (DS) proteoglycans, respectively]. Hyaluronic Acid 205-207 interleukin 1 beta Rattus norvegicus 44-53 8224206-0 1993 Interleukin-1 beta-induced cytosolic phospholipase A2 activity and protein synthesis is blocked by dexamethasone in rat mesangial cells. Dexamethasone 99-112 interleukin 1 beta Rattus norvegicus 0-18 8404691-5 1993 Treatment of whole ovarian dispersates with IL-1 beta (10 ng/ml) produced substantial increments in the accumulation of extracellular macromolecular material [11.5-, 2.9- and 2.6-fold for hyaluronic acid (HA), heparan sulfate (HS) and dermatan sulfate (DS) proteoglycans, respectively]. Heparitin Sulfate 210-225 interleukin 1 beta Rattus norvegicus 44-53 8404691-5 1993 Treatment of whole ovarian dispersates with IL-1 beta (10 ng/ml) produced substantial increments in the accumulation of extracellular macromolecular material [11.5-, 2.9- and 2.6-fold for hyaluronic acid (HA), heparan sulfate (HS) and dermatan sulfate (DS) proteoglycans, respectively]. Heparitin Sulfate 227-229 interleukin 1 beta Rattus norvegicus 44-53 8224206-1 1993 Interleukin-1 beta induces gene expression and secretion of the secretory phospholipase A2 (sPLA2) and prostaglandin E2 (PGE2) release from rat mesangial cells. Dinoprostone 103-119 interleukin 1 beta Rattus norvegicus 0-18 8404691-5 1993 Treatment of whole ovarian dispersates with IL-1 beta (10 ng/ml) produced substantial increments in the accumulation of extracellular macromolecular material [11.5-, 2.9- and 2.6-fold for hyaluronic acid (HA), heparan sulfate (HS) and dermatan sulfate (DS) proteoglycans, respectively]. Dermatan Sulfate 235-251 interleukin 1 beta Rattus norvegicus 44-53 8224206-1 1993 Interleukin-1 beta induces gene expression and secretion of the secretory phospholipase A2 (sPLA2) and prostaglandin E2 (PGE2) release from rat mesangial cells. Dinoprostone 121-125 interleukin 1 beta Rattus norvegicus 0-18 8404691-5 1993 Treatment of whole ovarian dispersates with IL-1 beta (10 ng/ml) produced substantial increments in the accumulation of extracellular macromolecular material [11.5-, 2.9- and 2.6-fold for hyaluronic acid (HA), heparan sulfate (HS) and dermatan sulfate (DS) proteoglycans, respectively]. Dermatan Sulfate 253-255 interleukin 1 beta Rattus norvegicus 44-53 8224206-3 1993 This effect of IL-1 beta on the cPLA2 activity is inhibited by actinomycin D and cycloheximide, indicating that both transcription and translation are involved. Dactinomycin 63-76 interleukin 1 beta Rattus norvegicus 15-24 8238334-4 1993 Pretreatment of rats with ALVA-42 (6 micrograms icv) inhibited the thermogenic and pyrogenic responses to intracerebroventricular injection of 5 ng (but not 50 ng) of IL-1 beta in conscious rats but did not significantly modify responses to IL-1 alpha. alva-42 26-33 interleukin 1 beta Rattus norvegicus 167-176 8224206-3 1993 This effect of IL-1 beta on the cPLA2 activity is inhibited by actinomycin D and cycloheximide, indicating that both transcription and translation are involved. Cycloheximide 81-94 interleukin 1 beta Rattus norvegicus 15-24 8224206-5 1993 In parallel with the effect of dexamethasone on the sPLA2, this glucocorticoid inhibits the IL-1 beta-enhanced cPLA2 activity as a result of the suppression of IL-1 beta-induced cPLA2 gene expression. Dexamethasone 31-44 interleukin 1 beta Rattus norvegicus 92-101 8224206-5 1993 In parallel with the effect of dexamethasone on the sPLA2, this glucocorticoid inhibits the IL-1 beta-enhanced cPLA2 activity as a result of the suppression of IL-1 beta-induced cPLA2 gene expression. Dexamethasone 31-44 interleukin 1 beta Rattus norvegicus 160-169 8279678-7 1993 Blood samples obtained 1-2 hr later indicated that the alcohol diet resulted in significantly blunted adrenocorticotropic hormone (ACTH) and beta-endorphin, but not corticosterone release, in response to IL-1 beta. Alcohols 55-62 interleukin 1 beta Rattus norvegicus 204-213 8279678-10 1993 These results suggest that prenatal exposure to alcohol interferes with the stimulatory action of IL-1 beta on the secretion of POMC-related peptides, a phenomenon probably not caused by decreased pituitary responsiveness to CRF. Alcohols 48-55 interleukin 1 beta Rattus norvegicus 98-107 8279679-3 1993 Administration of 1.5 g EtOH/kg, on the other hand, resulted in elevated plasma ACTH and corticosterone 30 min later, and significantly decreased the magnitude of the ACTH response to IL-1 beta in both intact and ADX rats. Ethanol 24-28 interleukin 1 beta Rattus norvegicus 184-193 8238440-4 1993 Naloxone, the opiate antagonist, but not naloxone methiodide, its quaternary salt that does not penetrate the blood-brain barrier (both administered at 10 mg/kg ip), antagonized this action of IL-1 beta. Naloxone 0-8 interleukin 1 beta Rattus norvegicus 193-202 8238440-7 1993 The inhibitory effect of naloxone suggests that central opiates are required for this action of IL-1 beta. Naloxone 25-33 interleukin 1 beta Rattus norvegicus 96-105 8238454-4 1993 In contrast, icv injection of alpha-helical CRF9-41 (10 micrograms) significantly attenuated hypertension, tachycardia, or fever induced by icv injection of IL-1 beta (20 ng). icv 13-16 interleukin 1 beta Rattus norvegicus 157-166 8238454-4 1993 In contrast, icv injection of alpha-helical CRF9-41 (10 micrograms) significantly attenuated hypertension, tachycardia, or fever induced by icv injection of IL-1 beta (20 ng). icv 140-143 interleukin 1 beta Rattus norvegicus 157-166 8255177-0 1993 In situ hybridization study of interleukin-1 beta mRNA induced by kainic acid in the rat brain. Kainic Acid 66-77 interleukin 1 beta Rattus norvegicus 31-49 8255177-1 1993 The distribution patterns of interleukin-1 beta (IL-1 beta) mRNA in various brain regions of saline- and kainic acid-treated rats were examined using in situ hybridization technique. Sodium Chloride 93-99 interleukin 1 beta Rattus norvegicus 29-47 8255177-1 1993 The distribution patterns of interleukin-1 beta (IL-1 beta) mRNA in various brain regions of saline- and kainic acid-treated rats were examined using in situ hybridization technique. Sodium Chloride 93-99 interleukin 1 beta Rattus norvegicus 49-58 8255177-1 1993 The distribution patterns of interleukin-1 beta (IL-1 beta) mRNA in various brain regions of saline- and kainic acid-treated rats were examined using in situ hybridization technique. Kainic Acid 105-116 interleukin 1 beta Rattus norvegicus 29-47 8255177-1 1993 The distribution patterns of interleukin-1 beta (IL-1 beta) mRNA in various brain regions of saline- and kainic acid-treated rats were examined using in situ hybridization technique. Kainic Acid 105-116 interleukin 1 beta Rattus norvegicus 49-58 8255177-3 1993 In the case of the kainic acid treatment, IL-1 beta mRNA was intensely induced in the olfactory bulb, lateral septum, thalamus, hypothalamus, polymorphic layers of hippocampus, piriform cortex, amygdala, entorhinal cortex and cerebral cortex at 2 h after the injection of kainic acid. Kainic Acid 19-30 interleukin 1 beta Rattus norvegicus 42-51 8255177-3 1993 In the case of the kainic acid treatment, IL-1 beta mRNA was intensely induced in the olfactory bulb, lateral septum, thalamus, hypothalamus, polymorphic layers of hippocampus, piriform cortex, amygdala, entorhinal cortex and cerebral cortex at 2 h after the injection of kainic acid. Kainic Acid 272-283 interleukin 1 beta Rattus norvegicus 42-51 8255177-5 1993 The signal of IL-1 beta mRNA was still expressed 4 h after treatment with kainic acid, less intensely than at 2 h, but above the control level. Kainic Acid 74-85 interleukin 1 beta Rattus norvegicus 14-23 8255177-6 1993 In these regions, IL-1 beta mRNA was expressed mainly in the glial cells, which were densely stained by Cresyl violet and did not contain glial fibrillary acidic protein. cresyl violet 104-117 interleukin 1 beta Rattus norvegicus 18-27 7691579-6 1993 rIL-1 beta induced the expression of iNOS mRNA in RIN cells and a 12- to 13-fold increase in medium nitrite accumulation, the latter indicating NO production. Nitrites 100-107 interleukin 1 beta Rattus norvegicus 0-10 7691579-8 1993 Thus, 10 mM nicotinamide decreased rIL-1 beta-induced nitrite formation by 30%, 20 mM by 60%, and 50 mM by 90%. Niacinamide 12-24 interleukin 1 beta Rattus norvegicus 35-45 7691579-8 1993 Thus, 10 mM nicotinamide decreased rIL-1 beta-induced nitrite formation by 30%, 20 mM by 60%, and 50 mM by 90%. Nitrites 54-61 interleukin 1 beta Rattus norvegicus 35-45 7691579-9 1993 The highest concentration of nicotinamide also prevented rIL-1 beta-induced iNOS mRNA, an effect associated with inhibition of total protein biosynthesis. Niacinamide 29-41 interleukin 1 beta Rattus norvegicus 57-67 7691579-11 1993 Dexamethasone also decreased rIL-1 beta-induced nitrite production without affecting iNOS mRNA expression. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 29-39 7691579-11 1993 Dexamethasone also decreased rIL-1 beta-induced nitrite production without affecting iNOS mRNA expression. Nitrites 48-55 interleukin 1 beta Rattus norvegicus 29-39 8236352-3 1993 METHODS: Rat interleukin-1 beta cDNA, synthesized from stimulated rat peritoneal macrophage RNA by reverse transcription and polymerase chain reaction and cloned in plasmid Bluescript KS+, was used to evaluate the expression of interleukin-1 beta mRNA in cerebral cortex from spontaneously hypertensive rats and normotensive rats subjected to permanent middle cerebral artery occlusion. Potassium 184-187 interleukin 1 beta Rattus norvegicus 13-31 8281441-6 1993 injection of IL-1 beta was 65% smaller after dVNAB-X, but was doubled after vVNAB-X or cVNAB-X. dvnab-x 45-52 interleukin 1 beta Rattus norvegicus 13-22 7691660-2 1993 Interleukin-1 beta, interleukin-6 and transforming growth factor-beta synergize with hydrocortisone, increasing the synthesis of alpha 2-macroglobulin 2- to 4-fold, although they have no effect in the absence of hydrocortisone. Hydrocortisone 85-99 interleukin 1 beta Rattus norvegicus 0-18 7691660-2 1993 Interleukin-1 beta, interleukin-6 and transforming growth factor-beta synergize with hydrocortisone, increasing the synthesis of alpha 2-macroglobulin 2- to 4-fold, although they have no effect in the absence of hydrocortisone. Hydrocortisone 212-226 interleukin 1 beta Rattus norvegicus 0-18 8252417-7 1993 The results suggest that IL-1 beta in the brain produces hyperalgesia by its receptor-mediated and prostaglandin-dependent action which is sensitive to alpha-MSH. Prostaglandins 99-112 interleukin 1 beta Rattus norvegicus 25-34 8279659-0 1993 Effect of exposure to an alcohol diet for 10 days on the ability of interleukin-1 beta to release ACTH and corticosterone in the adult ovariectomized female rat. Alcohols 25-32 interleukin 1 beta Rattus norvegicus 68-86 8279659-0 1993 Effect of exposure to an alcohol diet for 10 days on the ability of interleukin-1 beta to release ACTH and corticosterone in the adult ovariectomized female rat. Corticosterone 107-121 interleukin 1 beta Rattus norvegicus 68-86 8238334-4 1993 Pretreatment of rats with ALVA-42 (6 micrograms icv) inhibited the thermogenic and pyrogenic responses to intracerebroventricular injection of 5 ng (but not 50 ng) of IL-1 beta in conscious rats but did not significantly modify responses to IL-1 alpha. icv 48-51 interleukin 1 beta Rattus norvegicus 167-176 8373422-5 1993 Addition of 25 U/ml of interleukin-1 beta during the last 24 h of culture, led to a marked inhibition of glucose-stimulated insulin release and a 5-6 fold increase in nitrite production by rat insulinoma cells. Glucose 105-112 interleukin 1 beta Rattus norvegicus 23-41 8405292-2 1993 Interleukin-1 beta (0.5-1 pmol) and 1,25-dihydroxyvitamin D3 (25-25,000 pmol) were extremely potent inducers of NGF mRNA, being respectively at least 50,000 and 4000 times more potent than 4-methylcatechol. 4-methylcatechol 189-205 interleukin 1 beta Rattus norvegicus 0-18 8397260-3 1993 An in vitro platelet aggregation bioassay was used to assess the effects of interleukin-1 beta (IL-1 beta) on the release of platelet-activating factor and nitric oxide from resting or ionophore-activated peritoneal mast cells (PMC) from rat. Nitric Oxide 156-168 interleukin 1 beta Rattus norvegicus 76-94 8397260-3 1993 An in vitro platelet aggregation bioassay was used to assess the effects of interleukin-1 beta (IL-1 beta) on the release of platelet-activating factor and nitric oxide from resting or ionophore-activated peritoneal mast cells (PMC) from rat. Nitric Oxide 156-168 interleukin 1 beta Rattus norvegicus 96-105 8397260-6 1993 Within minutes, IL-1 beta concentration-dependently (1 pg/ml-100 ng/ml) enhanced the release from activated PMC of nitric oxide, as measured by its ability to inhibit thrombin-induced platelet aggregation, and as confirmed with a biochemical assay for nitrite. Nitric Oxide 115-127 interleukin 1 beta Rattus norvegicus 16-25 8397260-6 1993 Within minutes, IL-1 beta concentration-dependently (1 pg/ml-100 ng/ml) enhanced the release from activated PMC of nitric oxide, as measured by its ability to inhibit thrombin-induced platelet aggregation, and as confirmed with a biochemical assay for nitrite. Nitrites 252-259 interleukin 1 beta Rattus norvegicus 16-25 8397260-7 1993 This action of IL-1 beta was inhibited by pretreatment of PMC with a calmodulin antagonist (calmidazolium), an IL-1 receptor antagonist, or either of two nitric oxide synthase inhibitors (L-NAME and LY-83583). calmidazolium 92-105 interleukin 1 beta Rattus norvegicus 15-24 8397260-7 1993 This action of IL-1 beta was inhibited by pretreatment of PMC with a calmodulin antagonist (calmidazolium), an IL-1 receptor antagonist, or either of two nitric oxide synthase inhibitors (L-NAME and LY-83583). NG-Nitroarginine Methyl Ester 188-194 interleukin 1 beta Rattus norvegicus 15-24 8397260-7 1993 This action of IL-1 beta was inhibited by pretreatment of PMC with a calmodulin antagonist (calmidazolium), an IL-1 receptor antagonist, or either of two nitric oxide synthase inhibitors (L-NAME and LY-83583). 6-anilino-5,8-quinolinedione 199-207 interleukin 1 beta Rattus norvegicus 15-24 8397260-8 1993 IL-1 beta also inhibited the release of platelet-activating factor from PMC through a nitric-oxide-dependent mechanism. Nitric Oxide 86-98 interleukin 1 beta Rattus norvegicus 0-9 8397260-9 1993 These results demonstrate that IL-1 beta is a potent and rapid-acting modulator of mast cell reactivity, stimulating nitric oxide release while inhibiting the production of platelet-activating factor. Nitric Oxide 117-129 interleukin 1 beta Rattus norvegicus 31-40 7690801-6 1993 IL-1 beta alone (40 to 1000 U/ml) induced formation of increasing amounts of nitrite with increasing concentrations of IL-1 beta present. Nitrites 77-84 interleukin 1 beta Rattus norvegicus 0-9 7690801-6 1993 IL-1 beta alone (40 to 1000 U/ml) induced formation of increasing amounts of nitrite with increasing concentrations of IL-1 beta present. Nitrites 77-84 interleukin 1 beta Rattus norvegicus 119-128 8373422-5 1993 Addition of 25 U/ml of interleukin-1 beta during the last 24 h of culture, led to a marked inhibition of glucose-stimulated insulin release and a 5-6 fold increase in nitrite production by rat insulinoma cells. Nitrites 167-174 interleukin 1 beta Rattus norvegicus 23-41 8395530-4 1993 Pretreatment of the cells with TPA (10(-7) M) abolished the subsequent response to IL-1 beta, TGF-alpha, and EGF and at the same time resulted in > 90% reduction of cytosolic protein kinase C activity. Tetradecanoylphorbol Acetate 31-34 interleukin 1 beta Rattus norvegicus 83-92 8395530-7 1993 Dexamethasone was less effective in ablating the IL-1 beta response yielding 60% reduction M(r) 95K GL and little or no reduction of FIB-CL. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 49-58 8395530-7 1993 Dexamethasone was less effective in ablating the IL-1 beta response yielding 60% reduction M(r) 95K GL and little or no reduction of FIB-CL. glycylleucine 100-102 interleukin 1 beta Rattus norvegicus 49-58 8214107-2 1993 Because the molecular mechanisms that underlie induction of iNOS are still unclear and because tyrosine kinases are implicated in interleukin-1 beta (IL-1 beta)-induced prostaglandin synthesis in mesangial cells and in NO generation by an insulinoma cell line, we investigated the influence of tyrosine kinase inhibitors on iNOS induction in cultured rat aortic smooth muscle cells (RASMC). Prostaglandins 169-182 interleukin 1 beta Rattus norvegicus 130-148 8214107-2 1993 Because the molecular mechanisms that underlie induction of iNOS are still unclear and because tyrosine kinases are implicated in interleukin-1 beta (IL-1 beta)-induced prostaglandin synthesis in mesangial cells and in NO generation by an insulinoma cell line, we investigated the influence of tyrosine kinase inhibitors on iNOS induction in cultured rat aortic smooth muscle cells (RASMC). Prostaglandins 169-182 interleukin 1 beta Rattus norvegicus 150-159 8214107-3 1993 The production of biologically active NO was demonstrated by L-arginine-dependent guanosine 3",5"-cyclic monophosphate (cGMP) accumulation after a 3-h exposure to either IL-1 beta or lipopolysaccharide (LPS). Arginine 61-71 interleukin 1 beta Rattus norvegicus 170-179 8214107-3 1993 The production of biologically active NO was demonstrated by L-arginine-dependent guanosine 3",5"-cyclic monophosphate (cGMP) accumulation after a 3-h exposure to either IL-1 beta or lipopolysaccharide (LPS). Cyclic GMP 82-118 interleukin 1 beta Rattus norvegicus 170-179 8214107-3 1993 The production of biologically active NO was demonstrated by L-arginine-dependent guanosine 3",5"-cyclic monophosphate (cGMP) accumulation after a 3-h exposure to either IL-1 beta or lipopolysaccharide (LPS). Cyclic GMP 120-124 interleukin 1 beta Rattus norvegicus 170-179 8214107-4 1993 Pretreatment of RASMC for 30 min with the tyrosine kinase inhibitor genistein prevented both IL-1 beta- and LPS-elicited cGMP accumulation in a concentration-dependent manner. rasmc 16-21 interleukin 1 beta Rattus norvegicus 93-102 8214107-4 1993 Pretreatment of RASMC for 30 min with the tyrosine kinase inhibitor genistein prevented both IL-1 beta- and LPS-elicited cGMP accumulation in a concentration-dependent manner. Genistein 68-77 interleukin 1 beta Rattus norvegicus 93-102 8214107-4 1993 Pretreatment of RASMC for 30 min with the tyrosine kinase inhibitor genistein prevented both IL-1 beta- and LPS-elicited cGMP accumulation in a concentration-dependent manner. Cyclic GMP 121-125 interleukin 1 beta Rattus norvegicus 93-102 8214107-5 1993 Geldanamycin, a chemically different tyrosine kinase inhibitor, also blocked cGMP formation in response to both LPS and IL-1 beta at nanomolar concentrations. geldanamycin 0-12 interleukin 1 beta Rattus norvegicus 120-129 8214107-5 1993 Geldanamycin, a chemically different tyrosine kinase inhibitor, also blocked cGMP formation in response to both LPS and IL-1 beta at nanomolar concentrations. Cyclic GMP 77-81 interleukin 1 beta Rattus norvegicus 120-129 8376550-0 1993 Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes: synergism with IL-1 beta and TNF alpha. Norepinephrine 0-14 interleukin 1 beta Rattus norvegicus 101-110 7689960-8 1993 L-arginine also reduced IL-1 beta-stimulated AVP release. Arginine 0-10 interleukin 1 beta Rattus norvegicus 24-33 8405748-2 1993 In vitro islet exposure to interleukin 1 beta inhibits the beta-cell response to glucose. Glucose 81-88 interleukin 1 beta Rattus norvegicus 27-45 8405748-5 1993 When islets were pre-exposed to interleukin 1 beta, insulin release was significantly reduced in response to glucose (323 +/- 80, p < 0.001) but not in response to glyburide (1316 +/- 185). Glucose 109-116 interleukin 1 beta Rattus norvegicus 32-50 8405748-8 1993 In contrast, in interleukin 1 beta pre-exposed islets both glucose and glyburide stimulation only slightly modified 86Rb efflux (decrement of -19 +/- 1.9% and -5.3 +/- 3.1%, respectively, n = 5, p < 0.001). Glucose 59-66 interleukin 1 beta Rattus norvegicus 16-34 8405748-8 1993 In contrast, in interleukin 1 beta pre-exposed islets both glucose and glyburide stimulation only slightly modified 86Rb efflux (decrement of -19 +/- 1.9% and -5.3 +/- 3.1%, respectively, n = 5, p < 0.001). Glyburide 71-80 interleukin 1 beta Rattus norvegicus 16-34 8360772-10 1993 There was no accumulation of metallothionein with interleukin-1 beta, tumor necrosis factor alpha or interferon gamma (1 x 10(5) U/L) alone, but interleukin-1 beta and tumor necrosis factor alpha enhanced the response obtained with Zn+dexamethasone with and without interleukin-6. Zinc 232-234 interleukin 1 beta Rattus norvegicus 145-195 8360772-10 1993 There was no accumulation of metallothionein with interleukin-1 beta, tumor necrosis factor alpha or interferon gamma (1 x 10(5) U/L) alone, but interleukin-1 beta and tumor necrosis factor alpha enhanced the response obtained with Zn+dexamethasone with and without interleukin-6. Dexamethasone 235-248 interleukin 1 beta Rattus norvegicus 145-195 8401568-0 1993 Centrally injected interleukin-1 beta inhibits the hypothalamic LHRH secretion and circulating LH levels via prostaglandins in rats. Luteinizing Hormone 64-66 interleukin 1 beta Rattus norvegicus 19-37 8401568-0 1993 Centrally injected interleukin-1 beta inhibits the hypothalamic LHRH secretion and circulating LH levels via prostaglandins in rats. Prostaglandins 109-123 interleukin 1 beta Rattus norvegicus 19-37 8401568-1 1993 Intracerebroventricular (icv) infusion of interleukin-1 beta (IL-1 beta) significantly lowers plasma LH levels in castrated male rats, and interferes with LHRH release into the median eminence of proestrus female rats. Luteinizing Hormone 101-103 interleukin 1 beta Rattus norvegicus 42-60 8401568-1 1993 Intracerebroventricular (icv) infusion of interleukin-1 beta (IL-1 beta) significantly lowers plasma LH levels in castrated male rats, and interferes with LHRH release into the median eminence of proestrus female rats. Luteinizing Hormone 101-103 interleukin 1 beta Rattus norvegicus 62-71 8299008-0 1993 Repression of cytochrome P450 by cytokines: IL-1 beta counteracts clofibric acid induction of CYP4A in cultured fetal rat hepatocytes. Clofibric Acid 66-80 interleukin 1 beta Rattus norvegicus 44-53 8393485-0 1993 Interleukin-1 beta augments release of norepinephrine, dopamine, and serotonin in the rat anterior hypothalamus. Norepinephrine 39-53 interleukin 1 beta Rattus norvegicus 0-18 8393485-0 1993 Interleukin-1 beta augments release of norepinephrine, dopamine, and serotonin in the rat anterior hypothalamus. Dopamine 55-63 interleukin 1 beta Rattus norvegicus 0-18 8393485-0 1993 Interleukin-1 beta augments release of norepinephrine, dopamine, and serotonin in the rat anterior hypothalamus. Serotonin 69-78 interleukin 1 beta Rattus norvegicus 0-18 8393485-1 1993 We investigated the effects of interleukin-1 beta (IL-1 beta), administered directly into the rat anterior hypothalamus (AHY), on monoamine release in the same region by using a brain microdialysis technique and an HPLC-electrochemical detection system. monoamine 130-139 interleukin 1 beta Rattus norvegicus 31-49 8393485-1 1993 We investigated the effects of interleukin-1 beta (IL-1 beta), administered directly into the rat anterior hypothalamus (AHY), on monoamine release in the same region by using a brain microdialysis technique and an HPLC-electrochemical detection system. monoamine 130-139 interleukin 1 beta Rattus norvegicus 51-60 8393485-3 1993 IL-1 beta (1 ng) injected directly into the AHY elicited release of norepinephrine (NE), dopamine (DA), and 5-HT, as well as increases in their metabolites, 4-hydroxy-3-methoxyphenylglycol, 3,4-dihydroxyphenylacetic acid, 4-hydroxy-3-methoxyphenylacetic acid, and 5-hydroxyindole-3-acetic acid, in the AHY. Norepinephrine 68-82 interleukin 1 beta Rattus norvegicus 0-9 8393485-3 1993 IL-1 beta (1 ng) injected directly into the AHY elicited release of norepinephrine (NE), dopamine (DA), and 5-HT, as well as increases in their metabolites, 4-hydroxy-3-methoxyphenylglycol, 3,4-dihydroxyphenylacetic acid, 4-hydroxy-3-methoxyphenylacetic acid, and 5-hydroxyindole-3-acetic acid, in the AHY. Dopamine 89-97 interleukin 1 beta Rattus norvegicus 0-9 8393485-3 1993 IL-1 beta (1 ng) injected directly into the AHY elicited release of norepinephrine (NE), dopamine (DA), and 5-HT, as well as increases in their metabolites, 4-hydroxy-3-methoxyphenylglycol, 3,4-dihydroxyphenylacetic acid, 4-hydroxy-3-methoxyphenylacetic acid, and 5-hydroxyindole-3-acetic acid, in the AHY. Dopamine 99-101 interleukin 1 beta Rattus norvegicus 0-9 8393485-3 1993 IL-1 beta (1 ng) injected directly into the AHY elicited release of norepinephrine (NE), dopamine (DA), and 5-HT, as well as increases in their metabolites, 4-hydroxy-3-methoxyphenylglycol, 3,4-dihydroxyphenylacetic acid, 4-hydroxy-3-methoxyphenylacetic acid, and 5-hydroxyindole-3-acetic acid, in the AHY. Serotonin 108-112 interleukin 1 beta Rattus norvegicus 0-9 8393485-3 1993 IL-1 beta (1 ng) injected directly into the AHY elicited release of norepinephrine (NE), dopamine (DA), and 5-HT, as well as increases in their metabolites, 4-hydroxy-3-methoxyphenylglycol, 3,4-dihydroxyphenylacetic acid, 4-hydroxy-3-methoxyphenylacetic acid, and 5-hydroxyindole-3-acetic acid, in the AHY. Methoxyhydroxyphenylglycol 157-188 interleukin 1 beta Rattus norvegicus 0-9 8393485-3 1993 IL-1 beta (1 ng) injected directly into the AHY elicited release of norepinephrine (NE), dopamine (DA), and 5-HT, as well as increases in their metabolites, 4-hydroxy-3-methoxyphenylglycol, 3,4-dihydroxyphenylacetic acid, 4-hydroxy-3-methoxyphenylacetic acid, and 5-hydroxyindole-3-acetic acid, in the AHY. 3,4-Dihydroxyphenylacetic Acid 190-220 interleukin 1 beta Rattus norvegicus 0-9 8393485-3 1993 IL-1 beta (1 ng) injected directly into the AHY elicited release of norepinephrine (NE), dopamine (DA), and 5-HT, as well as increases in their metabolites, 4-hydroxy-3-methoxyphenylglycol, 3,4-dihydroxyphenylacetic acid, 4-hydroxy-3-methoxyphenylacetic acid, and 5-hydroxyindole-3-acetic acid, in the AHY. Homovanillic Acid 222-258 interleukin 1 beta Rattus norvegicus 0-9 8393485-3 1993 IL-1 beta (1 ng) injected directly into the AHY elicited release of norepinephrine (NE), dopamine (DA), and 5-HT, as well as increases in their metabolites, 4-hydroxy-3-methoxyphenylglycol, 3,4-dihydroxyphenylacetic acid, 4-hydroxy-3-methoxyphenylacetic acid, and 5-hydroxyindole-3-acetic acid, in the AHY. Hydroxyindoleacetic Acid 264-293 interleukin 1 beta Rattus norvegicus 0-9 8393485-5 1993 Although the elevated levels of NE and DA persisted for more than 6 hr after injection of IL-1 beta, the elevated levels of 5-HT were transient. Dopamine 39-41 interleukin 1 beta Rattus norvegicus 90-99 8393485-7 1993 IL-1 beta (0.1 and 1 nM) increased the levels of each monoamine released from hypothalamic slices in a dose-dependent manner. monoamine 54-63 interleukin 1 beta Rattus norvegicus 0-9 8415812-0 1993 Inhibition of the thermogenic and pyrogenic responses to interleukin-1 beta in the rat by dietary N-3 fatty acid supplementation. Fatty Acids, Omega-3 98-112 interleukin 1 beta Rattus norvegicus 57-75 8415812-9 1993 These findings demonstrate that n-3 supplementation modifies the pyrogenic and thermogenic responses to IL-1 beta, probably via changes in eicosanoid metabolism. Nitrogen 8-9 interleukin 1 beta Rattus norvegicus 104-113 8415812-9 1993 These findings demonstrate that n-3 supplementation modifies the pyrogenic and thermogenic responses to IL-1 beta, probably via changes in eicosanoid metabolism. Eicosanoids 139-149 interleukin 1 beta Rattus norvegicus 104-113 8396869-9 1993 Indomethacin abolished the AVP and ACTH responses to IL-1 beta, but potentiated the pressor and hypothermic responses and increased plasma ANP. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 53-62 8396869-10 1993 These data suggest that the actions of IL-1 beta on AVP and ACTH release and thermogenesis, but not on blood pressure and the release of ANP, are modulated by the stimulated central production of prostaglandins. Prostaglandins 196-210 interleukin 1 beta Rattus norvegicus 39-48 8398001-0 1993 Enhanced production of nitric oxide in aortae from spontaneously hypertensive rats by interleukin-1 beta. Nitric Oxide 23-35 interleukin 1 beta Rattus norvegicus 86-104 8398001-1 1993 Cultured aortic smooth muscle cells from spontaneously hypertensive rats produce more nitrite than cells from Wistar-Kyoto rats in response to interleukin-1 beta. Nitrites 86-93 interleukin 1 beta Rattus norvegicus 143-161 8398001-2 1993 Therefore, the effect of interleukin-1 beta-induced nitric oxide production was compared on the contractility of aortic smooth muscle from spontaneously hypertensive and Wistar-Kyoto rats. Nitric Oxide 52-64 interleukin 1 beta Rattus norvegicus 25-43 8398001-7 1993 Nitro-L-arginine prevented the inhibitory effect of interleukin-1 beta. Nitroarginine 0-16 interleukin 1 beta Rattus norvegicus 52-70 8398001-11 1993 Interleukin-1 beta elicited greater concentration-dependent productions of cyclic GMP and nitrite in rings from spontaneously hypertensive than from Wistar-Kyoto rats, and these were inhibited by methylene blue and nitro-L-arginine, respectively. Cyclic GMP 75-85 interleukin 1 beta Rattus norvegicus 0-18 8398001-11 1993 Interleukin-1 beta elicited greater concentration-dependent productions of cyclic GMP and nitrite in rings from spontaneously hypertensive than from Wistar-Kyoto rats, and these were inhibited by methylene blue and nitro-L-arginine, respectively. Nitrites 90-97 interleukin 1 beta Rattus norvegicus 0-18 8398001-11 1993 Interleukin-1 beta elicited greater concentration-dependent productions of cyclic GMP and nitrite in rings from spontaneously hypertensive than from Wistar-Kyoto rats, and these were inhibited by methylene blue and nitro-L-arginine, respectively. Methylene Blue 196-210 interleukin 1 beta Rattus norvegicus 0-18 8398001-11 1993 Interleukin-1 beta elicited greater concentration-dependent productions of cyclic GMP and nitrite in rings from spontaneously hypertensive than from Wistar-Kyoto rats, and these were inhibited by methylene blue and nitro-L-arginine, respectively. Nitroarginine 215-231 interleukin 1 beta Rattus norvegicus 0-18 8299008-6 1993 Interleukin-1 beta adversely affected P4504A clofibric acid-induced activity, totally eliminating the effect of induction at doses exceeding 5 ng/ml. Clofibric Acid 45-59 interleukin 1 beta Rattus norvegicus 0-18 8319564-0 1993 Evidence that luteinizing hormone suppression in response to inhibitory neuropeptides, beta-endorphin, interleukin-1 beta, and neuropeptide-K, may involve excitatory amino acids. Excitatory Amino Acids 155-177 interleukin 1 beta Rattus norvegicus 103-121 8281294-5 1993 Here we provide evidence that interferon-gamma (IFN-gamma), interleukin (IL)-1 beta and tumour necrosis factor-alpha induce L-arginine-dependent cyclic GMP synthesis in C6 cells and that a combination of IFN-gamma and IL-1 beta induce L-arginine-dependent cyclic GMP synthesis in astrocyte cultures, indicating that these cytokines induce NOS. Arginine 124-134 interleukin 1 beta Rattus norvegicus 218-227 8319564-3 1993 The aim of this study was to test the hypothesis that inhibition of LH release by an opioid [beta-endorphin (beta END)], cytokine [interleukin-1 beta (IL-1 beta)], or tachykinin [neuropeptide-K (NPK)] is a result of diminished excitatory amino acid (EAA) signaling. Luteinizing Hormone 68-70 interleukin 1 beta Rattus norvegicus 151-160 8319564-9 1993 However, similar NMDA injections completely prevented the decrease in LH release by beta END, IL-1 beta, or NPK. N-Methylaspartate 17-21 interleukin 1 beta Rattus norvegicus 94-103 7686532-3 1993 Interleukin-1 beta dose dependently (1 to 20 ng/mL) stimulated NO2-/NO3- production as a function of time. Nitrogen Dioxide 63-66 interleukin 1 beta Rattus norvegicus 0-18 7686532-3 1993 Interleukin-1 beta dose dependently (1 to 20 ng/mL) stimulated NO2-/NO3- production as a function of time. punky blue 68-71 interleukin 1 beta Rattus norvegicus 0-18 7686532-5 1993 NG-Monomethyl L-arginine completely blocked the interleukin-1 beta-induced NO2-/NO3- production, the effect of which was reversed by L-arginine but not by D-arginine. omega-N-Methylarginine 0-24 interleukin 1 beta Rattus norvegicus 48-66 7686532-5 1993 NG-Monomethyl L-arginine completely blocked the interleukin-1 beta-induced NO2-/NO3- production, the effect of which was reversed by L-arginine but not by D-arginine. Nitrogen Dioxide 75-78 interleukin 1 beta Rattus norvegicus 48-66 7686532-5 1993 NG-Monomethyl L-arginine completely blocked the interleukin-1 beta-induced NO2-/NO3- production, the effect of which was reversed by L-arginine but not by D-arginine. punky blue 80-83 interleukin 1 beta Rattus norvegicus 48-66 7686532-5 1993 NG-Monomethyl L-arginine completely blocked the interleukin-1 beta-induced NO2-/NO3- production, the effect of which was reversed by L-arginine but not by D-arginine. Arginine 14-24 interleukin 1 beta Rattus norvegicus 48-66 7686532-6 1993 Dexamethasone inhibited the interleukin-1 beta-induced NO2-/NO3- production in a dose-dependent manner (10(-9) to 10(-7) M) and the interleukin-1 beta-inducible nitric oxide synthase messenger RNA levels. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 28-46 7686532-6 1993 Dexamethasone inhibited the interleukin-1 beta-induced NO2-/NO3- production in a dose-dependent manner (10(-9) to 10(-7) M) and the interleukin-1 beta-inducible nitric oxide synthase messenger RNA levels. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 132-150 7686532-7 1993 Neither a calmodulin inhibitor (W-7) nor a protein kinase C inhibitor (staurosporine) showed any effects on the induction of nitric oxide synthase transcripts or production of NO2-/NO3- stimulated by interleukin-1 beta, whereas cycloheximide and actinomycin D completely inhibited the basal and stimulated NO2-/NO3- production. punky blue 181-184 interleukin 1 beta Rattus norvegicus 200-218 7686532-8 1993 These data demonstrate for the first time that interleukin-1 beta induces gene expression of inducible nitric oxide synthase and its de novo protein synthesis in rat vascular smooth muscle cells, thereby leading to generation of nitric oxide via Ca2+/calmodulin-independent and protein kinase C-independent mechanisms. Nitric Oxide 103-115 interleukin 1 beta Rattus norvegicus 47-65 8348296-8 1993 In contrast, 50 ng IL-1 beta was less effective (P < 0.05) when administered at 08.30 h, and totally without effect when infused at 14.30 h. Infusion of 50 ng IL-1 beta also markedly suppressed the hypothalamic release of LH-RH in proestrus rats bearing a push-pull cannula into the ME, and significantly decreased plasma LH levels in both gonadectomized male and female rats. Luteinizing Hormone 225-227 interleukin 1 beta Rattus norvegicus 19-28 8392427-4 1993 administration of IL-1 alpha or IL-1 beta suppressed LH release, but IL-1 beta was relatively more effective than IL-1 alpha in terms of the onset (IL-1 beta = 30 min; IL-1 alpha = 105 min) as well as the magnitude and duration of LH suppression. Luteinizing Hormone 53-55 interleukin 1 beta Rattus norvegicus 32-41 8348296-8 1993 In contrast, 50 ng IL-1 beta was less effective (P < 0.05) when administered at 08.30 h, and totally without effect when infused at 14.30 h. Infusion of 50 ng IL-1 beta also markedly suppressed the hypothalamic release of LH-RH in proestrus rats bearing a push-pull cannula into the ME, and significantly decreased plasma LH levels in both gonadectomized male and female rats. Luteinizing Hormone 225-227 interleukin 1 beta Rattus norvegicus 162-171 8348296-10 1993 These results provide the first direct evidence that IL-1 beta is a potent inhibitor of LH-RH neuronal activity during the proestrus LH surge in intact cycling rats. Luteinizing Hormone 88-90 interleukin 1 beta Rattus norvegicus 53-62 8505340-6 1993 Forskolin (7.5 microM), follicle-stimulating hormone (500 ng/ml) and luteinizing hormone (500 ng/ml) induced CAT activity following transfection with the -2698/32PGS.CAT, whereas gonadotropin-releasing hormone (10(-6) M) and interleukin-1 beta (30 ng/ml) had no effect. Colforsin 0-9 interleukin 1 beta Rattus norvegicus 225-243 8513508-2 1993 A comparison of IL-1 expression between macrophages from a PG-APS-resistant (BUF) and PG-APS-sensitive (LEW) rat strain revealed that while mRNA levels for IL-1 alpha and IL-1 beta were equivalent for the two strains, supernatants from BUF macrophages were less potent than LEW supernatants at stimulating thymocyte proliferation and contained less immunoreactive IL-1 alpha and IL-1 beta protein. pg-aps 59-65 interleukin 1 beta Rattus norvegicus 171-180 8513508-2 1993 A comparison of IL-1 expression between macrophages from a PG-APS-resistant (BUF) and PG-APS-sensitive (LEW) rat strain revealed that while mRNA levels for IL-1 alpha and IL-1 beta were equivalent for the two strains, supernatants from BUF macrophages were less potent than LEW supernatants at stimulating thymocyte proliferation and contained less immunoreactive IL-1 alpha and IL-1 beta protein. pg-aps 86-92 interleukin 1 beta Rattus norvegicus 171-180 8500722-11 1993 The IL-1 beta effect was also blocked by cycloheximide and was spontaneously reversible after 60 minutes. Cycloheximide 41-54 interleukin 1 beta Rattus norvegicus 4-13 8500722-12 1993 CONCLUSION: It was concluded that IL-1 beta suppresses ACh release via the formation and release of a protein mediator that could be another cytokine, including IL-1. Acetylcholine 55-58 interleukin 1 beta Rattus norvegicus 34-43 8500722-0 1993 Human recombinant interleukin 1 beta suppresses acetylcholine release from rat myenteric plexus. Acetylcholine 48-61 interleukin 1 beta Rattus norvegicus 18-36 8500722-3 1993 Therefore, the ability of IL-1 beta to alter ACh release in longitudinal muscle-myenteric plexus (LMMP) preparations from noninfected rats was examined. Acetylcholine 45-48 interleukin 1 beta Rattus norvegicus 26-35 8500722-8 1993 A marked suppression of ACh release was observed in tissues that had been preincubated with IL-1 beta for 60 minutes or more. Acetylcholine 24-27 interleukin 1 beta Rattus norvegicus 92-101 8392427-12 1993 infusion of the opiate receptor antagonist, naloxone, which on its own had no effect on LH secretion, counteracted the inhibitory effects of IL-1 beta. Naloxone 44-52 interleukin 1 beta Rattus norvegicus 141-150 8413817-8 1993 The marked increases in CRF-41 and AVP release from hypothalami from adrenalectomized rats initiated in vitro by IL1 alpha, IL-1 beta, IL-6 and IL-8 were readily overcome by preincubation of the tissue with dexamethasone (10(-7) M). Dexamethasone 207-220 interleukin 1 beta Rattus norvegicus 124-133 8385904-2 1993 Hepatocytes exposed to IFN-gamma, TNF-alpha, IL-1 beta, and LPS demonstrated the appearance of a g = 2.04 axial EPR signal indicative of the formation of nonheme iron-nitrosyl complexes. Iron 162-166 interleukin 1 beta Rattus norvegicus 45-54 8471066-1 1993 Normal rat kidney fibroblasts (NRK-49F cells) stimulated with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) produced mainly cytokine-induced neutrophil chemoattractant (CINC) which is the rat counterpart of human gro/melanoma growth stimulatory activity. Zinc 198-202 interleukin 1 beta Rattus norvegicus 62-80 8471066-1 1993 Normal rat kidney fibroblasts (NRK-49F cells) stimulated with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) produced mainly cytokine-induced neutrophil chemoattractant (CINC) which is the rat counterpart of human gro/melanoma growth stimulatory activity. Zinc 198-202 interleukin 1 beta Rattus norvegicus 82-91 8471066-3 1993 IL-1 beta was a stronger stimulator than TNF-alpha, and addition of both the cytokines into the NRK-49F cell culture caused an additive stimulation for rat gro/CINC production. Zinc 160-164 interleukin 1 beta Rattus norvegicus 0-9 8471066-4 1993 The anti-inflammatory steroids (dexamethasone, prednisolone and hydrocortisone) at 10(-9)-10(-6) M significantly suppressed the production of rat gro/CINC by the IL-1 beta-stimulated NRK-49F cells in a dose-dependent manner. Steroids 22-30 interleukin 1 beta Rattus norvegicus 162-171 8471066-4 1993 The anti-inflammatory steroids (dexamethasone, prednisolone and hydrocortisone) at 10(-9)-10(-6) M significantly suppressed the production of rat gro/CINC by the IL-1 beta-stimulated NRK-49F cells in a dose-dependent manner. Dexamethasone 32-45 interleukin 1 beta Rattus norvegicus 162-171 8471066-4 1993 The anti-inflammatory steroids (dexamethasone, prednisolone and hydrocortisone) at 10(-9)-10(-6) M significantly suppressed the production of rat gro/CINC by the IL-1 beta-stimulated NRK-49F cells in a dose-dependent manner. Prednisolone 47-59 interleukin 1 beta Rattus norvegicus 162-171 8471066-4 1993 The anti-inflammatory steroids (dexamethasone, prednisolone and hydrocortisone) at 10(-9)-10(-6) M significantly suppressed the production of rat gro/CINC by the IL-1 beta-stimulated NRK-49F cells in a dose-dependent manner. Hydrocortisone 64-78 interleukin 1 beta Rattus norvegicus 162-171 8387184-0 1993 The dipeptide Lys-Pro attenuates interleukin-1 beta-induced anorexia. Dipeptides 4-13 interleukin 1 beta Rattus norvegicus 33-51 8481768-5 1993 IL-1 beta-induced CRH release was also investigated in the presence of D-arginine (D-ARG), which is not active as a precursor to NO, and ferrous hemoglobin (Hb), a substance which is a potent inactivator of NO. D-Arginine 71-81 interleukin 1 beta Rattus norvegicus 0-9 8481768-5 1993 IL-1 beta-induced CRH release was also investigated in the presence of D-arginine (D-ARG), which is not active as a precursor to NO, and ferrous hemoglobin (Hb), a substance which is a potent inactivator of NO. D-Arginine 83-88 interleukin 1 beta Rattus norvegicus 0-9 8461008-0 1993 Interleukin 1 beta regulates glycogen metabolism in primary cultured rat hepatocytes. Glycogen 29-37 interleukin 1 beta Rattus norvegicus 0-18 8461008-2 1993 When IL-1 beta was present at 8 nM in the culture medium for 15 hours prior to cell harvest, glycogen storage in hepatocytes was lowered approximately by 60% of the control. Glycogen 93-101 interleukin 1 beta Rattus norvegicus 5-14 8461008-5 1993 The data demonstrate for the first time that IL-1 beta lowers the intracellular glycogen contents in primary cultured rat hepatocytes. Glycogen 80-88 interleukin 1 beta Rattus norvegicus 45-54 8387184-0 1993 The dipeptide Lys-Pro attenuates interleukin-1 beta-induced anorexia. lysylproline 14-21 interleukin 1 beta Rattus norvegicus 33-51 8387184-1 1993 The carboxyl-terminal tripeptide of alpha-MSH(1-13), Lys-Pro-Val, antagonizes anorexia induced by interleukin-1 beta (IL-1). tripeptide K-26 22-32 interleukin 1 beta Rattus norvegicus 98-116 7680540-2 1993 IL-1 beta stimulated the release of nitrite (a stable oxidation product of nitric oxide) from cultured smooth muscle cells. Nitrites 36-43 interleukin 1 beta Rattus norvegicus 0-9 8095098-5 1993 Angiopeptin induced a transient decrease in basal and interleukin-1-beta-induced cyclic AMP levels in endothelial cells. Cyclic AMP 81-91 interleukin 1 beta Rattus norvegicus 54-72 8095098-6 1993 Exposure of unstimulated and interleukin-1-beta-activated endothelial cells to KT5720, a specific inhibitor of cyclic AMP-dependent protein kinase, decreased endothelial cell adhesiveness for mononuclear cells. KT 5720 79-85 interleukin 1 beta Rattus norvegicus 29-47 7680540-6 1993 The addition of IL-1 beta-treated smooth muscle cells to suspensions of indomethacin-treated platelets inhibited their aggregation. Indomethacin 72-84 interleukin 1 beta Rattus norvegicus 16-25 7680540-2 1993 IL-1 beta stimulated the release of nitrite (a stable oxidation product of nitric oxide) from cultured smooth muscle cells. Nitric Oxide 75-87 interleukin 1 beta Rattus norvegicus 0-9 7680540-3 1993 Thrombin inhibited in a concentration-dependent manner the release of nitrite caused by IL-1 beta. Nitrites 70-77 interleukin 1 beta Rattus norvegicus 88-97 8424804-7 1993 The enantioselective influence of IL-1 beta treatment on the pharmacokinetics of propranolol was also present in 12- and 24-month-old rats, although somewhat less pronounced in the latter group. Propranolol 81-92 interleukin 1 beta Rattus norvegicus 34-43 8440413-4 1993 We demonstrate that a 1-h pretreatment of islets with IL-1 beta followed by an 8-h incubation in the absence of this cytokine results in inhibition of glucose-stimulated insulin secretion (50%), which is completely prevented by pretreatment of islets with the nitric oxide synthase inhibitor NG-monomethyl-L-arginine (NMMA). omega-N-Methylarginine 292-316 interleukin 1 beta Rattus norvegicus 54-63 8440413-4 1993 We demonstrate that a 1-h pretreatment of islets with IL-1 beta followed by an 8-h incubation in the absence of this cytokine results in inhibition of glucose-stimulated insulin secretion (50%), which is completely prevented by pretreatment of islets with the nitric oxide synthase inhibitor NG-monomethyl-L-arginine (NMMA). omega-N-Methylarginine 318-322 interleukin 1 beta Rattus norvegicus 54-63 8440413-5 1993 The production of nitric oxide by islets under these pulse conditions is demonstrated by IL-1 beta-induced nitrite and electron paramagnetic resonance-detectable iron-nitrosyl complex formation, both of which are prevented by NMMA. Nitric Oxide 18-30 interleukin 1 beta Rattus norvegicus 89-98 8440413-5 1993 The production of nitric oxide by islets under these pulse conditions is demonstrated by IL-1 beta-induced nitrite and electron paramagnetic resonance-detectable iron-nitrosyl complex formation, both of which are prevented by NMMA. Nitrites 107-114 interleukin 1 beta Rattus norvegicus 89-98 8440413-5 1993 The production of nitric oxide by islets under these pulse conditions is demonstrated by IL-1 beta-induced nitrite and electron paramagnetic resonance-detectable iron-nitrosyl complex formation, both of which are prevented by NMMA. omega-N-Methylarginine 226-230 interleukin 1 beta Rattus norvegicus 89-98 8440413-7 1993 The signaling process appears to require the activation of a tyrosine kinase, since the tyrosine kinase inhibitor genistein prevents both IL-1 beta-induced inhibition of insulin secretion by islets and formation of nitric oxide by the insulinoma cell line RINm5F. Genistein 114-123 interleukin 1 beta Rattus norvegicus 138-147 8440413-8 1993 These results show that short exposures of islets to IL-1 beta are sufficient to induce the formation of nitric oxide resulting in inhibition of glucose-stimulated insulin secretion and that a tyrosine kinase may participate in the early signaling events required for IL-1 beta to induce the expression of nitric oxide synthase. Nitric Oxide 105-117 interleukin 1 beta Rattus norvegicus 53-62 8440413-8 1993 These results show that short exposures of islets to IL-1 beta are sufficient to induce the formation of nitric oxide resulting in inhibition of glucose-stimulated insulin secretion and that a tyrosine kinase may participate in the early signaling events required for IL-1 beta to induce the expression of nitric oxide synthase. Nitric Oxide 105-117 interleukin 1 beta Rattus norvegicus 268-277 8440413-8 1993 These results show that short exposures of islets to IL-1 beta are sufficient to induce the formation of nitric oxide resulting in inhibition of glucose-stimulated insulin secretion and that a tyrosine kinase may participate in the early signaling events required for IL-1 beta to induce the expression of nitric oxide synthase. Glucose 145-152 interleukin 1 beta Rattus norvegicus 53-62 8440413-0 1993 A 1-hour pulse with IL-1 beta induces formation of nitric oxide and inhibits insulin secretion by rat islets of Langerhans: evidence for a tyrosine kinase signaling mechanism. Nitric Oxide 51-63 interleukin 1 beta Rattus norvegicus 20-29 8440413-1 1993 Nitric oxide has been implicated as the effector molecule that mediates interleukin-1 beta (IL-1 beta)-induced inhibition of glucose-stimulated insulin secretion by rat islets. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 72-90 8440413-1 1993 Nitric oxide has been implicated as the effector molecule that mediates interleukin-1 beta (IL-1 beta)-induced inhibition of glucose-stimulated insulin secretion by rat islets. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 92-101 8440413-1 1993 Nitric oxide has been implicated as the effector molecule that mediates interleukin-1 beta (IL-1 beta)-induced inhibition of glucose-stimulated insulin secretion by rat islets. Glucose 125-132 interleukin 1 beta Rattus norvegicus 72-90 8440413-1 1993 Nitric oxide has been implicated as the effector molecule that mediates interleukin-1 beta (IL-1 beta)-induced inhibition of glucose-stimulated insulin secretion by rat islets. Glucose 125-132 interleukin 1 beta Rattus norvegicus 92-101 8440413-2 1993 Brief exposures of islets (1 h) to IL-1 beta have been shown to inhibit glucose-stimulated insulin secretion at 8 or 18 h after removal of this cytokine. Glucose 72-79 interleukin 1 beta Rattus norvegicus 35-44 8440413-3 1993 The purpose of this investigation was to determine if brief exposures of islets to IL-1 beta are sufficient to induce the formation of nitric oxide and to examine the signaling process associated with IL-1 beta-induced expression of nitric oxide synthase. Nitric Oxide 135-147 interleukin 1 beta Rattus norvegicus 83-92 8440413-4 1993 We demonstrate that a 1-h pretreatment of islets with IL-1 beta followed by an 8-h incubation in the absence of this cytokine results in inhibition of glucose-stimulated insulin secretion (50%), which is completely prevented by pretreatment of islets with the nitric oxide synthase inhibitor NG-monomethyl-L-arginine (NMMA). Glucose 151-158 interleukin 1 beta Rattus norvegicus 54-63 8440413-4 1993 We demonstrate that a 1-h pretreatment of islets with IL-1 beta followed by an 8-h incubation in the absence of this cytokine results in inhibition of glucose-stimulated insulin secretion (50%), which is completely prevented by pretreatment of islets with the nitric oxide synthase inhibitor NG-monomethyl-L-arginine (NMMA). nitric 260-266 interleukin 1 beta Rattus norvegicus 54-63 8432782-4 1993 After 48 h of culture in the presence of rIL-1 beta, the human islets showed an increased insulin release during short term incubations in the presence of 1.7 or 16.7 mM glucose. Glucose 170-177 interleukin 1 beta Rattus norvegicus 41-51 8432782-8 1993 Rat islets exposed for 48 h in culture to the same concentrations of rIL-1 beta, however, showed a 40-60% decrease in insulin accumulation into the medium, glucose-induced insulin release, and glucose oxidation. Glucose 156-163 interleukin 1 beta Rattus norvegicus 69-79 8432782-8 1993 Rat islets exposed for 48 h in culture to the same concentrations of rIL-1 beta, however, showed a 40-60% decrease in insulin accumulation into the medium, glucose-induced insulin release, and glucose oxidation. Glucose 193-200 interleukin 1 beta Rattus norvegicus 69-79 8424804-8 1993 Our results show an enantioselective influence of IL-1 beta treatment on the pharmacokinetics of propranolol in the rat, favouring the (R)-enantiomer. Propranolol 97-108 interleukin 1 beta Rattus norvegicus 50-59 8427512-0 1993 Inhibition of interleukin 1 beta induced rat and human cartilage degradation in vitro by the metalloproteinase inhibitor U27391. U 27391 121-127 interleukin 1 beta Rattus norvegicus 14-32 8317326-1 1993 Using specific antisera for IL-1 beta and IL-8, as well as cyclooxygenase inhibitors and propranolol, we have demonstrated that these cytokines are responsible for the prostaglandin and sympathetic components of carrageenin-induced hyperalgesia in the rat paw test. Prostaglandins 168-181 interleukin 1 beta Rattus norvegicus 28-37 8317326-1 1993 Using specific antisera for IL-1 beta and IL-8, as well as cyclooxygenase inhibitors and propranolol, we have demonstrated that these cytokines are responsible for the prostaglandin and sympathetic components of carrageenin-induced hyperalgesia in the rat paw test. Carrageenan 212-223 interleukin 1 beta Rattus norvegicus 28-37 8430802-0 1993 Interleukin-1 beta modulation of norepinephrine release from rat myenteric nerves. Norepinephrine 33-47 interleukin 1 beta Rattus norvegicus 0-18 8430802-4 1993 IL-1 beta also stimulated the cycloheximide-sensitive uptake of [35S] methionine uptake by the tissue. Cycloheximide 30-43 interleukin 1 beta Rattus norvegicus 0-9 8430802-4 1993 IL-1 beta also stimulated the cycloheximide-sensitive uptake of [35S] methionine uptake by the tissue. Sulfur-35 65-68 interleukin 1 beta Rattus norvegicus 0-9 8430802-4 1993 IL-1 beta also stimulated the cycloheximide-sensitive uptake of [35S] methionine uptake by the tissue. Methionine 70-80 interleukin 1 beta Rattus norvegicus 0-9 8430802-8 1993 These results indicate that IL-1 beta suppresses [3H]NE release from rat myenteric plexus by two mechanisms, one of which is independent of protein synthesis and the other of which is mediated by endogenous IL-1. Tritium 50-52 interleukin 1 beta Rattus norvegicus 28-37 8384045-3 1993 In this study, we have determined whether ICV administration of IL-1 beta has an effect on sympathetic outflow and norepinephrine (NE) turnover in the spleen. Norepinephrine 115-129 interleukin 1 beta Rattus norvegicus 64-73 8418905-5 1993 TNF alpha and IL-1 beta stimulated production of prostaglandin E and prostaglandin F2 alpha in a dose-dependent manner during a 24-h incubation. Dinoprost 69-91 interleukin 1 beta Rattus norvegicus 14-23 8418905-6 1993 Synthesis of prostacyclin was also stimulated by TNF alpha and IL-1 beta, as indicated by high levels of its stable metabolite 6-keto-prostaglandin F1 alpha. Epoprostenol 13-25 interleukin 1 beta Rattus norvegicus 63-72 8418905-6 1993 Synthesis of prostacyclin was also stimulated by TNF alpha and IL-1 beta, as indicated by high levels of its stable metabolite 6-keto-prostaglandin F1 alpha. 6-Ketoprostaglandin F1 alpha 127-156 interleukin 1 beta Rattus norvegicus 63-72 8418905-8 1993 TNF alpha and IL-1 beta also dose-dependently increased the production of progesterone and this was not inhibited by indomethacin. Progesterone 74-86 interleukin 1 beta Rattus norvegicus 14-23 8319099-7 1993 These results coincide with the earlier finding that anisomycin inhibits both endotoxin- and IL-1 beta-induced fevers. Anisomycin 53-63 interleukin 1 beta Rattus norvegicus 93-102 8428219-0 1993 Nitric oxide mediates the inhibition by interleukin-1 beta of pentagastrin-stimulated rat gastric acid secretion. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 40-58 8428219-0 1993 Nitric oxide mediates the inhibition by interleukin-1 beta of pentagastrin-stimulated rat gastric acid secretion. Pentagastrin 62-74 interleukin 1 beta Rattus norvegicus 40-58 7686083-0 1993 Interleukin-1 beta increases 5-hydroxyindoleacetic acid release in the hypothalamus in vivo. Hydroxyindoleacetic Acid 29-55 interleukin 1 beta Rattus norvegicus 0-18 8418905-5 1993 TNF alpha and IL-1 beta stimulated production of prostaglandin E and prostaglandin F2 alpha in a dose-dependent manner during a 24-h incubation. Prostaglandins E 49-64 interleukin 1 beta Rattus norvegicus 14-23 8384045-0 1993 Central administration of interleukin-1 beta increases norepinephrine turnover in the spleen. Norepinephrine 55-69 interleukin 1 beta Rattus norvegicus 26-44 8384045-3 1993 In this study, we have determined whether ICV administration of IL-1 beta has an effect on sympathetic outflow and norepinephrine (NE) turnover in the spleen. icv 42-45 interleukin 1 beta Rattus norvegicus 64-73 8384045-6 1993 In addition, serum corticosterone and ACTH were significantly elevated in IL-1 beta-treated animals 4 h postinjection. Corticosterone 19-33 interleukin 1 beta Rattus norvegicus 74-83 8419137-8 1993 Ovarian release of progesterone and PGF2 alpha was increased by IL-1 beta, but estradiol and PGE release was not affected. Dinoprost 36-40 interleukin 1 beta Rattus norvegicus 64-73 7679657-0 1993 Interleukin-1 beta effects on cyclic GMP and cyclic AMP in cultured rat islets of Langerhans-arginine-dependence and relationship to insulin secretion. Cyclic AMP 45-55 interleukin 1 beta Rattus norvegicus 0-18 7679657-1 1993 When islets were cultured with interleukin-1 beta (1 or 100 pmol/l) for 12 h in arginine-containing medium, cyclic GMP levels were increased 1.6- and 4.5-fold respectively. Arginine 80-88 interleukin 1 beta Rattus norvegicus 31-49 7679657-2 1993 The arginine analogue, N-omega-nitro-L-arginine methyl ester, which blocks nitric oxide formation and partially reverses inhibition of insulin secretion by 100 pmol/l interleukin-1 beta, largely, but not completely, blocked generation of cyclic GMP. Arginine 4-12 interleukin 1 beta Rattus norvegicus 167-185 7679657-2 1993 The arginine analogue, N-omega-nitro-L-arginine methyl ester, which blocks nitric oxide formation and partially reverses inhibition of insulin secretion by 100 pmol/l interleukin-1 beta, largely, but not completely, blocked generation of cyclic GMP. NG-Nitroarginine Methyl Ester 23-60 interleukin 1 beta Rattus norvegicus 167-185 7679657-3 1993 Treatment of islets with 100 pmol/l interleukin-1 beta for 12 h significantly decreased islet cyclic AMP generation in the absence of isobutylmethylxanthine (from 13.1 +/- 0.7 to 9.3 +/- 0.8 fmol/micrograms islet protein), this fall was arginine-dependent and may have resulted from an effect on a cyclic AMP phosphodiesterase, since it was masked if isobutylmethylxanthine was present. Cyclic AMP 94-104 interleukin 1 beta Rattus norvegicus 36-54 7679657-3 1993 Treatment of islets with 100 pmol/l interleukin-1 beta for 12 h significantly decreased islet cyclic AMP generation in the absence of isobutylmethylxanthine (from 13.1 +/- 0.7 to 9.3 +/- 0.8 fmol/micrograms islet protein), this fall was arginine-dependent and may have resulted from an effect on a cyclic AMP phosphodiesterase, since it was masked if isobutylmethylxanthine was present. 1-Methyl-3-isobutylxanthine 134-156 interleukin 1 beta Rattus norvegicus 36-54 7679657-3 1993 Treatment of islets with 100 pmol/l interleukin-1 beta for 12 h significantly decreased islet cyclic AMP generation in the absence of isobutylmethylxanthine (from 13.1 +/- 0.7 to 9.3 +/- 0.8 fmol/micrograms islet protein), this fall was arginine-dependent and may have resulted from an effect on a cyclic AMP phosphodiesterase, since it was masked if isobutylmethylxanthine was present. Arginine 237-245 interleukin 1 beta Rattus norvegicus 36-54 7679657-3 1993 Treatment of islets with 100 pmol/l interleukin-1 beta for 12 h significantly decreased islet cyclic AMP generation in the absence of isobutylmethylxanthine (from 13.1 +/- 0.7 to 9.3 +/- 0.8 fmol/micrograms islet protein), this fall was arginine-dependent and may have resulted from an effect on a cyclic AMP phosphodiesterase, since it was masked if isobutylmethylxanthine was present. 1-Methyl-3-isobutylxanthine 351-373 interleukin 1 beta Rattus norvegicus 36-54 7679657-4 1993 Isobutylmethylxanthine (0.4 mmol/l) reduced the inhibitory potency of interleukin-1 beta in 15 h slightly but significantly from 80.5 to 59.0%. 1-Methyl-3-isobutylxanthine 0-22 interleukin 1 beta Rattus norvegicus 70-88 7679657-7 1993 Both low- and high-dose interleukin-1 beta treatment give a large arginine-dependent and a small, yet significant, arginine-independent increase in cyclic GMP. Arginine 66-74 interleukin 1 beta Rattus norvegicus 24-42 7679657-7 1993 Both low- and high-dose interleukin-1 beta treatment give a large arginine-dependent and a small, yet significant, arginine-independent increase in cyclic GMP. Arginine 115-123 interleukin 1 beta Rattus norvegicus 24-42 7679657-8 1993 The inhibitory effect of SIN-1 or interleukin-1 beta on insulin secretion seems to depend to a small extent on decreased islet cyclic AMP, though sustained increases in nitric oxide or depleted islet GTP may directly affect the secretory process. Cyclic AMP 127-137 interleukin 1 beta Rattus norvegicus 34-52 8419137-10 1993 To elucidate whether the IL-1 beta-stimulated ovarian synthesis of PGF2 alpha was crucial for the ovulatory effect of IL-1 beta, experiments were performed in the presence of indomethacin (5 micrograms/ml), an inhibitor of PG synthesis. Dinoprost 67-71 interleukin 1 beta Rattus norvegicus 25-34 8419137-10 1993 To elucidate whether the IL-1 beta-stimulated ovarian synthesis of PGF2 alpha was crucial for the ovulatory effect of IL-1 beta, experiments were performed in the presence of indomethacin (5 micrograms/ml), an inhibitor of PG synthesis. Prostaglandins 67-69 interleukin 1 beta Rattus norvegicus 25-34 8419137-12 1993 The number of ovulations in the group treated with LH and IL-1 beta was significantly reduced (3.2 +/- 0.6) in the presence of indomethacin. Indomethacin 127-139 interleukin 1 beta Rattus norvegicus 58-67 7683610-6 1993 In contrast, and unlike FK-506, CSA caused mesangiolysis (IC50 = 4.5 micrograms.ml-1) and concentration dependently inhibited the interleukin-1 beta (IL-1 beta) stimulated mesangial cell release of TXB2 at nanomolar doses (IC50 = 50 ng.ml-1). Cyclosporine 32-35 interleukin 1 beta Rattus norvegicus 130-148 8419137-13 1993 These data demonstrate that IL-1 beta induces ovulation in the rat ovary, and this effect may be partly mediated by the increased production of the ovulatory mediator progesterone. Progesterone 167-179 interleukin 1 beta Rattus norvegicus 28-37 7683610-6 1993 In contrast, and unlike FK-506, CSA caused mesangiolysis (IC50 = 4.5 micrograms.ml-1) and concentration dependently inhibited the interleukin-1 beta (IL-1 beta) stimulated mesangial cell release of TXB2 at nanomolar doses (IC50 = 50 ng.ml-1). Cyclosporine 32-35 interleukin 1 beta Rattus norvegicus 150-159 7683610-7 1993 In kinetic experiments (6-48 h), CSA 1 ng.ml-1 partially and 1 microgram.ml-1 completely abolished the IL-1 beta augmented mesangial secretion TXB2 at all the time points tested. Cyclosporine 33-36 interleukin 1 beta Rattus norvegicus 103-112 8505861-1 1993 The purpose of this study was to investigate the effects of circulating interleukin-1 beta (IL-1 beta) on the release of norepinephrine (NE) in the paraventricular nucleus (PVN). Norepinephrine 121-135 interleukin 1 beta Rattus norvegicus 72-90 8437508-3 1993 Intracerebroventricular injection of IL-1 beta (100 ng) decreased acid secretion in pylorus-ligated rats and inhibited basal and pentagastrin-stimulated acid secretion in rats with chronic gastric fistula. Pentagastrin 129-141 interleukin 1 beta Rattus norvegicus 37-46 8437508-8 1993 IL-1 beta antisecretory action can be observed under basal and pentagastrin-stimulated conditions and is independent from somatostatin release in the periphery. Pentagastrin 63-75 interleukin 1 beta Rattus norvegicus 0-9 7690108-1 1993 NG-Nitro-L-arginine, an inhibitor of nitric oxide synthase, does not influence CRH basal release but is able to modify ACTH basal secretion and to block interleukin-1 beta-induced CRH and ACTH release from rat hypothalamic and anterior pituitary cell cultures in vitro. Nitroarginine 0-19 interleukin 1 beta Rattus norvegicus 153-171 8505861-1 1993 The purpose of this study was to investigate the effects of circulating interleukin-1 beta (IL-1 beta) on the release of norepinephrine (NE) in the paraventricular nucleus (PVN). Norepinephrine 121-135 interleukin 1 beta Rattus norvegicus 92-101 7690108-0 1993 Involvement of nitric oxide in basal and interleukin-1 beta-induced CRH and ACTH release in vitro. Nitric Oxide 15-27 interleukin 1 beta Rattus norvegicus 41-59 8396470-7 1993 In the in vitro study, the superoxide production in normal rat blood PMNs was significantly higher in the presence of cytokines (IL-1 beta, IL-6, TNF-alpha) without dose-dependence but was not higher for the lentinan group than in the control. Superoxides 27-37 interleukin 1 beta Rattus norvegicus 129-138 18475500-5 1993 Serum corticosterone levels were measured only at 4 h. Significant increases in IL-1beta levels precede cell influx suggesting IL-1beta plays a role in the maintenance of cell accumulation in the pleural cavity. Corticosterone 6-20 interleukin 1 beta Rattus norvegicus 80-88 18475500-5 1993 Serum corticosterone levels were measured only at 4 h. Significant increases in IL-1beta levels precede cell influx suggesting IL-1beta plays a role in the maintenance of cell accumulation in the pleural cavity. Corticosterone 6-20 interleukin 1 beta Rattus norvegicus 127-135 18475500-8 1993 These results suggest that although IL-1beta levels increase in the pleural cavity in response to carrageenan, IL-1 per se is not the initiator of the pro-inflammatory events of cell influx and oedema in this model. Carrageenan 98-109 interleukin 1 beta Rattus norvegicus 36-44 8390701-0 1993 Interleukin-1 beta stimulates adrenocorticotropin and corticosterone release in 10-day-old rat pups. Corticosterone 54-68 interleukin 1 beta Rattus norvegicus 0-18 1460280-8 1992 Two protein kinase C (PKC) inhibitors, H7 and staurosporine, abrogate IFN-gamma/LPS- and IFN-gamma/IL-1 beta-induced TNF-alpha expression in a dose-dependent manner. Staurosporine 46-59 interleukin 1 beta Rattus norvegicus 99-108 1334975-9 1992 IL-1 beta induces the formation of an iron-dinitrosyl complex by Rin-m5F cells indicating that nitric oxide mediates the destruction of iron-sulfur clusters of iron containing enzymes. iron-dinitrosyl complex 38-61 interleukin 1 beta Rattus norvegicus 0-9 1334975-9 1992 IL-1 beta induces the formation of an iron-dinitrosyl complex by Rin-m5F cells indicating that nitric oxide mediates the destruction of iron-sulfur clusters of iron containing enzymes. Nitric Oxide 95-107 interleukin 1 beta Rattus norvegicus 0-9 1334975-0 1992 Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Nitric Oxide 44-56 interleukin 1 beta Rattus norvegicus 0-18 1334975-9 1992 IL-1 beta induces the formation of an iron-dinitrosyl complex by Rin-m5F cells indicating that nitric oxide mediates the destruction of iron-sulfur clusters of iron containing enzymes. Iron 38-42 interleukin 1 beta Rattus norvegicus 0-9 1334975-2 1992 Nitric oxide has recently been implicated as the effector molecule that mediates IL-1 beta-induced inhibition of glucose-stimulated insulin secretion and beta-cell specific destruction. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 81-90 1334975-2 1992 Nitric oxide has recently been implicated as the effector molecule that mediates IL-1 beta-induced inhibition of glucose-stimulated insulin secretion and beta-cell specific destruction. Glucose 113-120 interleukin 1 beta Rattus norvegicus 81-90 1334975-9 1992 IL-1 beta induces the formation of an iron-dinitrosyl complex by Rin-m5F cells indicating that nitric oxide mediates the destruction of iron-sulfur clusters of iron containing enzymes. Sulfur 141-147 interleukin 1 beta Rattus norvegicus 0-9 1334975-4 1992 The purpose of this investigation was to determine if the beta-cell, which is selectively destroyed during insulin-dependent diabetes mellitus, is both a source of IL-1 beta-induced nitric oxide production and also a site of action of this free radical. Nitric Oxide 182-194 interleukin 1 beta Rattus norvegicus 164-173 1334975-9 1992 IL-1 beta induces the formation of an iron-dinitrosyl complex by Rin-m5F cells indicating that nitric oxide mediates the destruction of iron-sulfur clusters of iron containing enzymes. Iron 136-140 interleukin 1 beta Rattus norvegicus 0-9 1334975-4 1992 The purpose of this investigation was to determine if the beta-cell, which is selectively destroyed during insulin-dependent diabetes mellitus, is both a source of IL-1 beta-induced nitric oxide production and also a site of action of this free radical. Free Radicals 240-252 interleukin 1 beta Rattus norvegicus 164-173 1334975-5 1992 Pretreatment of beta-cells, purified by FACS with IL-1 beta results in a 40% inhibition of glucose-stimulated insulin secretion that is prevented by the nitric oxide synthase inhibitor, NG-monomethyl-L-arginine (NMMA). Glucose 91-98 interleukin 1 beta Rattus norvegicus 50-59 1334975-10 1992 This is further demonstrated by IL-1 beta-induced inhibition of glucose oxidation by purified beta-cells, mitochondrial aconitase activity of dispersed islet cells, and mitochondrial aconitase activity of Rin-m5F cells, all of which are prevented by NMMA. Glucose 64-71 interleukin 1 beta Rattus norvegicus 32-41 1334975-5 1992 Pretreatment of beta-cells, purified by FACS with IL-1 beta results in a 40% inhibition of glucose-stimulated insulin secretion that is prevented by the nitric oxide synthase inhibitor, NG-monomethyl-L-arginine (NMMA). omega-N-Methylarginine 186-210 interleukin 1 beta Rattus norvegicus 50-59 1334975-10 1992 This is further demonstrated by IL-1 beta-induced inhibition of glucose oxidation by purified beta-cells, mitochondrial aconitase activity of dispersed islet cells, and mitochondrial aconitase activity of Rin-m5F cells, all of which are prevented by NMMA. omega-N-Methylarginine 250-254 interleukin 1 beta Rattus norvegicus 32-41 1334975-5 1992 Pretreatment of beta-cells, purified by FACS with IL-1 beta results in a 40% inhibition of glucose-stimulated insulin secretion that is prevented by the nitric oxide synthase inhibitor, NG-monomethyl-L-arginine (NMMA). omega-N-Methylarginine 212-216 interleukin 1 beta Rattus norvegicus 50-59 1334975-6 1992 IL-1 beta induces the formation of nitric oxide by purified beta-cells as evidenced by the accumulation of cGMP, which is blocked by NMMA. Nitric Oxide 35-47 interleukin 1 beta Rattus norvegicus 0-9 1334975-12 1992 These results demonstrate that the islet beta-cell is a source of IL-1 beta-induced nitric oxide production, and that beta-cell mitochondrial iron-sulfur containing enzymes are one site of action of nitric oxide. Nitric Oxide 84-96 interleukin 1 beta Rattus norvegicus 66-75 1334975-6 1992 IL-1 beta induces the formation of nitric oxide by purified beta-cells as evidenced by the accumulation of cGMP, which is blocked by NMMA. Cyclic GMP 107-111 interleukin 1 beta Rattus norvegicus 0-9 1280597-2 1992 In cultured rat lung fibroblasts the presence of L-arginine was necessary for the production of nitrite to be induced by rat recombinant interferon-gamma and synergistically enhanced by lipopolysaccharide and interleukin-1 beta. Arginine 49-59 interleukin 1 beta Rattus norvegicus 209-227 1334975-6 1992 IL-1 beta induces the formation of nitric oxide by purified beta-cells as evidenced by the accumulation of cGMP, which is blocked by NMMA. omega-N-Methylarginine 133-137 interleukin 1 beta Rattus norvegicus 0-9 1334975-7 1992 IL-1 beta also induces the accumulation of cGMP by the insulinoma cell line Rin-m5F, and both NMMA as well as the protein synthesis inhibitor cycloheximide prevent this cGMP accumulation. Cyclic GMP 43-47 interleukin 1 beta Rattus norvegicus 0-9 1334975-7 1992 IL-1 beta also induces the accumulation of cGMP by the insulinoma cell line Rin-m5F, and both NMMA as well as the protein synthesis inhibitor cycloheximide prevent this cGMP accumulation. Cycloheximide 142-155 interleukin 1 beta Rattus norvegicus 0-9 1334975-7 1992 IL-1 beta also induces the accumulation of cGMP by the insulinoma cell line Rin-m5F, and both NMMA as well as the protein synthesis inhibitor cycloheximide prevent this cGMP accumulation. Cyclic GMP 169-173 interleukin 1 beta Rattus norvegicus 0-9 1466764-8 1992 These data show that the structural integrity surrounding and perhaps including the Asn-Tyr-Pro-Lys region may be crucial for the biological activity of rIL-1 beta and may be important for the binding of IL-1 to its receptor. Asparagine 84-87 interleukin 1 beta Rattus norvegicus 153-163 1466764-8 1992 These data show that the structural integrity surrounding and perhaps including the Asn-Tyr-Pro-Lys region may be crucial for the biological activity of rIL-1 beta and may be important for the binding of IL-1 to its receptor. Tyrosine 88-91 interleukin 1 beta Rattus norvegicus 153-163 1466764-8 1992 These data show that the structural integrity surrounding and perhaps including the Asn-Tyr-Pro-Lys region may be crucial for the biological activity of rIL-1 beta and may be important for the binding of IL-1 to its receptor. Lysine 96-99 interleukin 1 beta Rattus norvegicus 153-163 1484875-2 1992 In the present experiment, a tripeptide IL-1 beta antagonist which blocked IL-1 beta-induced hyperalgesia was tested for the ability to block IL-1 beta-induced effects on food intake and body temperature. tripeptide K-26 29-39 interleukin 1 beta Rattus norvegicus 40-49 1484875-2 1992 In the present experiment, a tripeptide IL-1 beta antagonist which blocked IL-1 beta-induced hyperalgesia was tested for the ability to block IL-1 beta-induced effects on food intake and body temperature. tripeptide K-26 29-39 interleukin 1 beta Rattus norvegicus 75-84 1484875-2 1992 In the present experiment, a tripeptide IL-1 beta antagonist which blocked IL-1 beta-induced hyperalgesia was tested for the ability to block IL-1 beta-induced effects on food intake and body temperature. tripeptide K-26 29-39 interleukin 1 beta Rattus norvegicus 75-84 1484875-4 1992 The effect of 1.25 micrograms IL-1 beta/rat on food intake measured 4 and 22 h after (IP) injection was blocked by coadministration of 5 mg tripeptide IL-1 beta antagonist. tripeptide K-26 140-150 interleukin 1 beta Rattus norvegicus 30-39 1484875-4 1992 The effect of 1.25 micrograms IL-1 beta/rat on food intake measured 4 and 22 h after (IP) injection was blocked by coadministration of 5 mg tripeptide IL-1 beta antagonist. tripeptide K-26 140-150 interleukin 1 beta Rattus norvegicus 151-160 1484875-5 1992 However, 25 mg tripeptide IL-1 beta antagonist/rat plus 1.25 micrograms IL-1 beta/rat decreased 0-22 h food intake more than IL-1 beta alone. tripeptide K-26 15-25 interleukin 1 beta Rattus norvegicus 26-35 1484875-6 1992 Administration (IP) of 1.25 micrograms IL-1 beta/rat increased body temperature 1 degrees C 4 h later, and 5 and 25 mg tripeptide IL-1 beta antagonist/rat blocked this increase. tripeptide K-26 119-129 interleukin 1 beta Rattus norvegicus 130-139 1484875-7 1992 Although food intake remained decreased after IL-1 beta administration alone or with 25 mg tripeptide IL-1 beta antagonist/rat for 22 h, body temperature returned to normal under these conditions. tripeptide K-26 91-101 interleukin 1 beta Rattus norvegicus 102-111 1484875-8 1992 Thus, a tripeptide IL-1 beta antagonist shown to block IL-1 beta-induced hyperalgesia also blocked food intake and body temperature responses to IL-1 beta, although the effective doses of IL-1 beta and the tripeptide IL-1 beta antagonist differ by 4,000-fold when both are administered peripherally. tripeptide K-26 8-18 interleukin 1 beta Rattus norvegicus 19-28 1484875-8 1992 Thus, a tripeptide IL-1 beta antagonist shown to block IL-1 beta-induced hyperalgesia also blocked food intake and body temperature responses to IL-1 beta, although the effective doses of IL-1 beta and the tripeptide IL-1 beta antagonist differ by 4,000-fold when both are administered peripherally. tripeptide K-26 8-18 interleukin 1 beta Rattus norvegicus 55-64 1484875-8 1992 Thus, a tripeptide IL-1 beta antagonist shown to block IL-1 beta-induced hyperalgesia also blocked food intake and body temperature responses to IL-1 beta, although the effective doses of IL-1 beta and the tripeptide IL-1 beta antagonist differ by 4,000-fold when both are administered peripherally. tripeptide K-26 8-18 interleukin 1 beta Rattus norvegicus 55-64 1484875-8 1992 Thus, a tripeptide IL-1 beta antagonist shown to block IL-1 beta-induced hyperalgesia also blocked food intake and body temperature responses to IL-1 beta, although the effective doses of IL-1 beta and the tripeptide IL-1 beta antagonist differ by 4,000-fold when both are administered peripherally. tripeptide K-26 8-18 interleukin 1 beta Rattus norvegicus 55-64 1484875-8 1992 Thus, a tripeptide IL-1 beta antagonist shown to block IL-1 beta-induced hyperalgesia also blocked food intake and body temperature responses to IL-1 beta, although the effective doses of IL-1 beta and the tripeptide IL-1 beta antagonist differ by 4,000-fold when both are administered peripherally. tripeptide K-26 8-18 interleukin 1 beta Rattus norvegicus 55-64 1484875-8 1992 Thus, a tripeptide IL-1 beta antagonist shown to block IL-1 beta-induced hyperalgesia also blocked food intake and body temperature responses to IL-1 beta, although the effective doses of IL-1 beta and the tripeptide IL-1 beta antagonist differ by 4,000-fold when both are administered peripherally. tripeptide K-26 206-216 interleukin 1 beta Rattus norvegicus 19-28 1484875-8 1992 Thus, a tripeptide IL-1 beta antagonist shown to block IL-1 beta-induced hyperalgesia also blocked food intake and body temperature responses to IL-1 beta, although the effective doses of IL-1 beta and the tripeptide IL-1 beta antagonist differ by 4,000-fold when both are administered peripherally. tripeptide K-26 206-216 interleukin 1 beta Rattus norvegicus 55-64 1484875-8 1992 Thus, a tripeptide IL-1 beta antagonist shown to block IL-1 beta-induced hyperalgesia also blocked food intake and body temperature responses to IL-1 beta, although the effective doses of IL-1 beta and the tripeptide IL-1 beta antagonist differ by 4,000-fold when both are administered peripherally. tripeptide K-26 206-216 interleukin 1 beta Rattus norvegicus 55-64 1484875-8 1992 Thus, a tripeptide IL-1 beta antagonist shown to block IL-1 beta-induced hyperalgesia also blocked food intake and body temperature responses to IL-1 beta, although the effective doses of IL-1 beta and the tripeptide IL-1 beta antagonist differ by 4,000-fold when both are administered peripherally. tripeptide K-26 206-216 interleukin 1 beta Rattus norvegicus 55-64 1484875-8 1992 Thus, a tripeptide IL-1 beta antagonist shown to block IL-1 beta-induced hyperalgesia also blocked food intake and body temperature responses to IL-1 beta, although the effective doses of IL-1 beta and the tripeptide IL-1 beta antagonist differ by 4,000-fold when both are administered peripherally. tripeptide K-26 206-216 interleukin 1 beta Rattus norvegicus 55-64 1280597-2 1992 In cultured rat lung fibroblasts the presence of L-arginine was necessary for the production of nitrite to be induced by rat recombinant interferon-gamma and synergistically enhanced by lipopolysaccharide and interleukin-1 beta. Nitrites 96-103 interleukin 1 beta Rattus norvegicus 209-227 1396331-8 1992 Autoradiography after incubation with [3H]thymidine showed a dramatic increase in the number of labeled Leydig cells after treatment with IL-1 beta (19.27 +/- 3.77% vs. 1.44 +/- 0.52% in control cultures) indicating that IL-1 beta recruited more cells to enter the cell cycle and initiate DNA synthesis. Tritium 39-41 interleukin 1 beta Rattus norvegicus 138-147 1446669-6 1992 Measured with 1-stearoyl-2-[1-14C]arachidonoylglycero-phosphocholine as substrate, both interleukin-1 beta and transforming growth factor-beta 2 enhanced the high-molecular-mass phospholipase A2 activity. 1-stearoyl-2-[1-14c]arachidonoylglycero-phosphocholine 14-68 interleukin 1 beta Rattus norvegicus 88-144 1446669-10 1992 Whether interleukin-1 beta induced group-II phospholipase A2 and/or interleukin-1 beta-enhanced cytosolic phospholipase A2 activity is involved in prostaglandin E2 formation in rat mesangial cells is discussed. Dinoprostone 147-163 interleukin 1 beta Rattus norvegicus 68-86 1282674-0 1992 Role of nitric oxide in antagonistic effects of transforming growth factor-beta and interleukin-1 beta on the beating rate of cultured cardiac myocytes. Nitric Oxide 8-20 interleukin 1 beta Rattus norvegicus 84-102 1282674-3 1992 We now show that TGF beta and IL-1 beta also have antagonistic effects on the secretion of nitric oxide (NO) by these myocytes, and that NO secretion, the activity of NO synthase (NOS), and expression of the inducible form of NOS correlate inversely with the effects of these two agents on the beating rate. Nitric Oxide 91-103 interleukin 1 beta Rattus norvegicus 30-39 1282674-5 1992 Release of NO, induced by IL-1 beta, is dependent upon the availability of the substrate, L-arginine, and is suppressed by a competitive inhibitor, NG-monomethyl-L-arginine. Arginine 90-100 interleukin 1 beta Rattus norvegicus 26-35 1282674-5 1992 Release of NO, induced by IL-1 beta, is dependent upon the availability of the substrate, L-arginine, and is suppressed by a competitive inhibitor, NG-monomethyl-L-arginine. omega-N-Methylarginine 148-172 interleukin 1 beta Rattus norvegicus 26-35 1282674-7 1992 Treatment with IL-1 beta, but not TGF beta, increases cellular cGMP, presumably by activation of guanylate cyclase by NO. Cyclic GMP 63-67 interleukin 1 beta Rattus norvegicus 15-24 1282674-8 1992 Methylene blue, an inhibitor of guanylate cyclase, reverses the suppression of beating caused by IL-1 beta. Methylene Blue 0-14 interleukin 1 beta Rattus norvegicus 97-106 1446669-0 1992 Interleukin-1 beta and transforming growth factor-beta 2 enhance cytosolic high-molecular-mass phospholipase A2 activity and induce prostaglandin E2 formation in rat mesangial cells. Dinoprostone 132-148 interleukin 1 beta Rattus norvegicus 0-56 1446669-1 1992 Interleukin-1 beta induces gene expression and secretion of group-II phospholipase A2 and release of prostaglandin E2 from rat mesangial cells. Dinoprostone 101-117 interleukin 1 beta Rattus norvegicus 0-18 1446669-2 1992 The interleukin-1 beta-induced synthesis of group-II phospholipase A2 is prevented by transforming growth factor-beta 2, whereas transforming growth factor-beta 2 potentiated the interleukin-1 beta-evoked prostaglandin E2 production. Dinoprostone 205-221 interleukin 1 beta Rattus norvegicus 179-197 1446669-4 1992 Here we describe the effect of interleukin-1 beta and transforming growth factor-beta 2 on a cytosolic phospholipase A2 activity and prostaglandin E2 formation in rat mesangial cells. Dinoprostone 133-149 interleukin 1 beta Rattus norvegicus 31-87 1396331-8 1992 Autoradiography after incubation with [3H]thymidine showed a dramatic increase in the number of labeled Leydig cells after treatment with IL-1 beta (19.27 +/- 3.77% vs. 1.44 +/- 0.52% in control cultures) indicating that IL-1 beta recruited more cells to enter the cell cycle and initiate DNA synthesis. Tritium 39-41 interleukin 1 beta Rattus norvegicus 221-230 1415553-6 1992 IL-1 beta inhibitory action in the medial preoptic area was dose related (0.1-10 ng), prevented by indomethacin (5 mg/kg ip), and mimicked by prostaglandin E2. Indomethacin 99-111 interleukin 1 beta Rattus norvegicus 0-9 1329524-4 1992 Incubation of quartered adrenals with adrenocorticotropic hormone (ACTH, 10(-12) to 10(-8) M) or IL-1 beta (10(-12) to 10(-8) M) resulted in dose-dependent increases (P less than 0.05) in corticosterone release. Corticosterone 188-202 interleukin 1 beta Rattus norvegicus 97-106 1329524-5 1992 Corticosterone release stimulated by 10(-8) M doses of ACTH and IL-1 beta began to rise 30 min after incubation and peaked at 2 h. In primary cultures of adrenal cells, IL-1 alpha and IL-1 beta elevated corticosterone release after a 24-h incubation period. Corticosterone 0-14 interleukin 1 beta Rattus norvegicus 64-73 1415553-6 1992 IL-1 beta inhibitory action in the medial preoptic area was dose related (0.1-10 ng), prevented by indomethacin (5 mg/kg ip), and mimicked by prostaglandin E2. Dinoprostone 142-158 interleukin 1 beta Rattus norvegicus 0-9 1329524-5 1992 Corticosterone release stimulated by 10(-8) M doses of ACTH and IL-1 beta began to rise 30 min after incubation and peaked at 2 h. In primary cultures of adrenal cells, IL-1 alpha and IL-1 beta elevated corticosterone release after a 24-h incubation period. Corticosterone 0-14 interleukin 1 beta Rattus norvegicus 184-193 1415553-7 1992 These results show that IL-1 beta acts in the medial preoptic area/anterior hypothalamus and paraventricular nucleus to inhibit acid secretion in pylorus-ligated rats and that IL-1 beta action is likely to involve prostaglandin E2. Dinoprostone 214-230 interleukin 1 beta Rattus norvegicus 176-185 1329524-5 1992 Corticosterone release stimulated by 10(-8) M doses of ACTH and IL-1 beta began to rise 30 min after incubation and peaked at 2 h. In primary cultures of adrenal cells, IL-1 alpha and IL-1 beta elevated corticosterone release after a 24-h incubation period. Corticosterone 203-217 interleukin 1 beta Rattus norvegicus 64-73 1477295-7 1992 rIL-1 beta exerted a cytotoxic effect on islet cells only when added to cultures containing supraphysiological glucose concentrations. Glucose 111-118 interleukin 1 beta Rattus norvegicus 0-10 1329524-5 1992 Corticosterone release stimulated by 10(-8) M doses of ACTH and IL-1 beta began to rise 30 min after incubation and peaked at 2 h. In primary cultures of adrenal cells, IL-1 alpha and IL-1 beta elevated corticosterone release after a 24-h incubation period. Corticosterone 203-217 interleukin 1 beta Rattus norvegicus 184-193 1329524-9 1992 Both IL-1 alpha and IL-1 beta significantly increased (P less than 0.05) epinephrine levels after a 24-h incubation period compared with media-treated controls. Epinephrine 73-84 interleukin 1 beta Rattus norvegicus 20-29 1525118-0 1992 Continuous infusion of interleukin-1 beta in rats induces a profound fall in plasma levels of cholesterol and triglycerides. Cholesterol 94-105 interleukin 1 beta Rattus norvegicus 23-41 1525118-0 1992 Continuous infusion of interleukin-1 beta in rats induces a profound fall in plasma levels of cholesterol and triglycerides. Triglycerides 110-123 interleukin 1 beta Rattus norvegicus 23-41 1477295-8 1992 But, in the presence of 1 g/l glucose, the addition of rIL-1 beta (40 ng/ml) for prolonged periods (14 days), did not alter islet function. Glucose 30-37 interleukin 1 beta Rattus norvegicus 55-65 1508942-1 1992 The present studies were undertaken to determine whether interleukin 1 beta ([IL-1] 1.0 micrograms/kg, ip) pretreatment for 3 days impairs the adaptive response to sucrose feeding in rats. Sucrose 164-171 interleukin 1 beta Rattus norvegicus 57-75 1517398-4 1992 Dexamethasone also blocked the CRF response to IL-1 beta, indicating that activated glucocorticoid receptors can inhibit the response of CRF to IL-1 beta. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 47-56 1517398-4 1992 Dexamethasone also blocked the CRF response to IL-1 beta, indicating that activated glucocorticoid receptors can inhibit the response of CRF to IL-1 beta. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 144-153 1380466-1 1992 The suppressive and cytotoxic effects of interleukin-1 beta (IL-1 beta) on rodent insulin-producing cells observed in vitro are probably mediated through formation of nitric oxide (NO). Nitric Oxide 167-179 interleukin 1 beta Rattus norvegicus 41-59 1380466-1 1992 The suppressive and cytotoxic effects of interleukin-1 beta (IL-1 beta) on rodent insulin-producing cells observed in vitro are probably mediated through formation of nitric oxide (NO). Nitric Oxide 167-179 interleukin 1 beta Rattus norvegicus 61-70 1378415-5 1992 The cytokine IL-1 beta induces the formation of nitric oxide in isolated rat islets and the insulinoma cell line, Rin-m5F. Nitric Oxide 48-60 interleukin 1 beta Rattus norvegicus 13-22 1500722-1 1992 The effect of human rIL-1 beta on the release of arachidonic acid (AA) and on the phospholipase A2 (PLA2) activity in guinea pig eosinophils was investigated. Arachidonic Acid 49-65 interleukin 1 beta Rattus norvegicus 20-30 1500722-5 1992 However, prolonged incubation with human rIL-1 beta (30 to 180 min) inhibited in a concentration- and time-dependent manner the release of AA and the hydrolysis of phosphatidylcholine in ionophore-stimulated eosinophils. Phosphatidylcholines 164-183 interleukin 1 beta Rattus norvegicus 41-51 1500722-6 1992 Our results also showed that eosinophil homogenates contain a calcium-dependent PLA2 whose activity was markedly reduced when eosinophils were pretreated with human rIL-1 beta. Calcium 62-69 interleukin 1 beta Rattus norvegicus 165-175 1378360-8 1992 The depression of the concentration-contraction curves to phenylephrine and the increase of the tissue level of cGMP induced by interleukin-1 beta (4 hours) were more pronounced in balloon-injured arteries (24 hours) than in control arteries without endothelium. Cyclic GMP 112-116 interleukin 1 beta Rattus norvegicus 128-146 1378360-9 1992 The effects of interleukin-1 beta were inhibited by nitro-L-arginine. Nitroarginine 52-68 interleukin 1 beta Rattus norvegicus 15-33 1378360-10 1992 These observations indicate that in vivo endothelial injury of the rat carotid arteries induces the production of nitric oxide from L-arginine in the blood vessel wall, an effect which is potentiated by interleukin-1 beta. Nitric Oxide 114-126 interleukin 1 beta Rattus norvegicus 203-221 1378360-10 1992 These observations indicate that in vivo endothelial injury of the rat carotid arteries induces the production of nitric oxide from L-arginine in the blood vessel wall, an effect which is potentiated by interleukin-1 beta. Arginine 132-142 interleukin 1 beta Rattus norvegicus 203-221 1500722-8 1992 Finally, studies with Fura-2-loaded eosinophils showed that the ionophore A23187 stimulated an increase in intracellular calcium concentration that was not altered by pretreating the eosinophils with human rIL-1 beta. Calcimycin 74-80 interleukin 1 beta Rattus norvegicus 206-216 1500722-8 1992 Finally, studies with Fura-2-loaded eosinophils showed that the ionophore A23187 stimulated an increase in intracellular calcium concentration that was not altered by pretreating the eosinophils with human rIL-1 beta. Calcium 121-128 interleukin 1 beta Rattus norvegicus 206-216 1500722-9 1992 These results suggest that human rIL-1 beta inhibits the release of AA by eosinophils via the inhibition of a PLA2 activity and through a calcium-independent mechanism. Calcium 138-145 interleukin 1 beta Rattus norvegicus 33-43 1327836-5 1992 In the present study, we examined the possible involvement of hypothalamic catecholamines in the effect of IL-1 beta on hypothalamic CRF secretion, by using an in vitro rat hypothalami continuous perifusion system. Catecholamines 75-89 interleukin 1 beta Rattus norvegicus 107-116 1378415-6 1992 NMMA and NAME, both inhibitors of nitric oxide synthase, completely protect islets from the deleterious effects of IL-1 beta. N-methylmalonamic acid 0-4 interleukin 1 beta Rattus norvegicus 115-124 1322036-5 1992 At this latter time point, IL-1 beta also amplified the mitogenicity of growth hormone (GH) and 16.7 mM glucose. Glucose 104-111 interleukin 1 beta Rattus norvegicus 27-36 1634763-6 1992 As with poly(A).poly(U), mice given 4000 or 10,000 U or rIL-1 beta 3 h after deaggregated MTg (dMTg) were not resistant to EAT induced with MTg and adjuvant. dmtg 95-99 interleukin 1 beta Rattus norvegicus 56-66 1634763-6 1992 As with poly(A).poly(U), mice given 4000 or 10,000 U or rIL-1 beta 3 h after deaggregated MTg (dMTg) were not resistant to EAT induced with MTg and adjuvant. (Methylthio)acetic acid 96-99 interleukin 1 beta Rattus norvegicus 56-66 1634763-7 1992 Moreover, mice given 90,000 U or rIL-1 beta after dMTg and then immunized displayed very severe thyroiditis, strong in vitro proliferative response, and high antibody titers, compared with immunized controls, indicating a dose-dependent effect of rIL-1 beta. dmtg 50-54 interleukin 1 beta Rattus norvegicus 33-43 1634763-10 1992 In contrast, mice given 10,000 U of rIL-1 beta 3 h before dMTg and then challenged developed MTg antibodies but little thyroiditis, demonstrating that the interference with suppression of autoantibody responses can occur without altering the induction of suppression of thyroiditis. dmtg 58-62 interleukin 1 beta Rattus norvegicus 36-46 1634763-14 1992 Lastly, immunization of dMTg-pretreated mice with MTg and rIL-1 beta did not induce EAT, demonstrating that rIL-1 beta could not interfere with established suppression. dmtg 24-28 interleukin 1 beta Rattus norvegicus 58-68 1634763-14 1992 Lastly, immunization of dMTg-pretreated mice with MTg and rIL-1 beta did not induce EAT, demonstrating that rIL-1 beta could not interfere with established suppression. dmtg 24-28 interleukin 1 beta Rattus norvegicus 108-118 1634763-14 1992 Lastly, immunization of dMTg-pretreated mice with MTg and rIL-1 beta did not induce EAT, demonstrating that rIL-1 beta could not interfere with established suppression. (Methylthio)acetic acid 25-28 interleukin 1 beta Rattus norvegicus 58-68 1634763-15 1992 Thus, the intervention by rIL-1 beta in MTg-induced suppression occurs at a critical time, early after the injection of dMTg but before the establishment of resistance. (Methylthio)acetic acid 40-43 interleukin 1 beta Rattus norvegicus 26-36 1634763-15 1992 Thus, the intervention by rIL-1 beta in MTg-induced suppression occurs at a critical time, early after the injection of dMTg but before the establishment of resistance. dmtg 120-124 interleukin 1 beta Rattus norvegicus 26-36 1322036-6 1992 In contrast, basal as well as glucose- and GH-stimulated insulin secretion was consistently suppressed by IL-1 beta from days 1-3. Glucose 30-37 interleukin 1 beta Rattus norvegicus 106-115 1322036-7 1992 IL-1 beta also lowered the islet adenosine 3",5"-cyclic monophosphate (cAMP) content at all time points studied. Cyclic AMP 33-69 interleukin 1 beta Rattus norvegicus 0-9 1322036-7 1992 IL-1 beta also lowered the islet adenosine 3",5"-cyclic monophosphate (cAMP) content at all time points studied. Cyclic AMP 71-75 interleukin 1 beta Rattus norvegicus 0-9 1322036-8 1992 However, addition of the stimulatory cAMP analogue Sp-diastereomer of adenosine 3",5"-cyclic monophosphothioate or pertussis toxin, which themselves enhanced DNA synthesis and insulin secretion, failed to prevent the inhibitory actions of IL-1 beta on these parameters, making it unlikely that a decrease in cAMP is an important event in transduction of the inhibitory effects of the cytokine. Cyclic AMP 37-41 interleukin 1 beta Rattus norvegicus 239-248 1322036-8 1992 However, addition of the stimulatory cAMP analogue Sp-diastereomer of adenosine 3",5"-cyclic monophosphothioate or pertussis toxin, which themselves enhanced DNA synthesis and insulin secretion, failed to prevent the inhibitory actions of IL-1 beta on these parameters, making it unlikely that a decrease in cAMP is an important event in transduction of the inhibitory effects of the cytokine. TFF2 protein, human 51-53 interleukin 1 beta Rattus norvegicus 239-248 1325196-5 1992 Inflammation induced in the mouse ear by rIL-1 beta, rIL-6 or rTNF-alpha was inhibited by alpha-MSH and a D-valine-substituted analog of alpha-MSH(11-13) whereas substantial doses of alpha-MSH(1-13) did not alter inflammation induced by LTB4, PAF and IL-8. D-Valine 106-114 interleukin 1 beta Rattus norvegicus 41-51 1641074-0 1992 Interleukin-1 beta and interleukin-6 specifically increase the release of prostaglandin E2 from rat hypothalamic explants in vitro. Dinoprostone 74-90 interleukin 1 beta Rattus norvegicus 0-18 1515551-7 1992 Further, BHA blocked both rTNF-alpha-induced and rIL-1 beta-induced prostaglandin E2 synthesis in FS-4 fibroblasts. Butylated Hydroxyanisole 9-12 interleukin 1 beta Rattus norvegicus 49-59 1515551-7 1992 Further, BHA blocked both rTNF-alpha-induced and rIL-1 beta-induced prostaglandin E2 synthesis in FS-4 fibroblasts. Dinoprostone 68-84 interleukin 1 beta Rattus norvegicus 49-59 1641074-7 1992 The effect of IL-1 beta was antagonized by both indomethacin and dexamethasone. Indomethacin 48-60 interleukin 1 beta Rattus norvegicus 14-23 1641074-7 1992 The effect of IL-1 beta was antagonized by both indomethacin and dexamethasone. Dexamethasone 65-78 interleukin 1 beta Rattus norvegicus 14-23 1376744-11 1992 Synergism with IL-1 beta was also noted with the fibrogenic agent bleomycin. Bleomycin 66-75 interleukin 1 beta Rattus norvegicus 15-24 1386466-0 1992 Intracerebroventricular administration of a specific IL-1 receptor antagonist blocks food and water intake suppression induced by interleukin-1 beta. Water 94-99 interleukin 1 beta Rattus norvegicus 130-148 1327201-3 1992 By using cultured porcine Leydig cells as a model, we found that IL-1 alpha (and to a lesser extent IL-1 beta), contrary to previous reports, is a potent inhibitor of LH/hCG steroidogenic action; and we further localized the steroidogenic biochemical step(s) affected by IL-1 alpha. Luteinizing Hormone 167-169 interleukin 1 beta Rattus norvegicus 100-109 1327383-4 1992 Hyperalgesic responses to IL-1 beta were inhibited in a dose-dependent manner by alpha-melanocyte stimulating hormone (alpha-MSH)-related peptides with the following order of potency: [N1(4),D-Phe7]alpha-MSH greater than alpha-MSH greater than Lys-D-Pro-Val greater than Lys-Pro-Val greater than Lys-D-Pro-Thr greater than D-Lys-Pro-Thr. d-phe7 191-197 interleukin 1 beta Rattus norvegicus 26-35 1327383-4 1992 Hyperalgesic responses to IL-1 beta were inhibited in a dose-dependent manner by alpha-melanocyte stimulating hormone (alpha-MSH)-related peptides with the following order of potency: [N1(4),D-Phe7]alpha-MSH greater than alpha-MSH greater than Lys-D-Pro-Val greater than Lys-Pro-Val greater than Lys-D-Pro-Thr greater than D-Lys-Pro-Thr. lys-d-pro-val 244-257 interleukin 1 beta Rattus norvegicus 26-35 1327383-4 1992 Hyperalgesic responses to IL-1 beta were inhibited in a dose-dependent manner by alpha-melanocyte stimulating hormone (alpha-MSH)-related peptides with the following order of potency: [N1(4),D-Phe7]alpha-MSH greater than alpha-MSH greater than Lys-D-Pro-Val greater than Lys-Pro-Val greater than Lys-D-Pro-Thr greater than D-Lys-Pro-Thr. d-lys-pro-thr 323-336 interleukin 1 beta Rattus norvegicus 26-35 1327383-6 1992 Hyperalgesic responses to PGE2 were not inhibited by Lys-D-Pro-Thr and D-Lys-Pro-Thr but were inhibited in a dose-dependent manner by the other peptides with the same order of potency as against IL-1 beta. Dinoprostone 26-30 interleukin 1 beta Rattus norvegicus 195-204 1597143-2 1992 In orchiectomized rats, recombinant rat IL-1 alpha and IL-1 beta administered into the lateral ventricles almost equipotently suppressed plasma LH levels. Luteinizing Hormone 144-146 interleukin 1 beta Rattus norvegicus 55-64 1597143-7 1992 IL-1ra (10 micrograms) completely blocked LH suppression induced by 1 microgram IL-1 beta, but did not completely reverse the changes of LH induced by 5 micrograms LPS. Luteinizing Hormone 42-44 interleukin 1 beta Rattus norvegicus 80-89 1573395-0 1992 Interleukin-1-beta and tumor necrosis factor-alpha increase peripheral-type benzodiazepine binding sites in cultured polygonal astrocytes. Benzodiazepines 76-90 interleukin 1 beta Rattus norvegicus 0-18 1573395-8 1992 At 10-50 ng/ml, IL-1 beta and TNF-alpha elevated [3H]Ro 5-4864 binding in polygonal astrocyte cultures 65 and 87%, respectively, above the level in control cultures. Tritium 50-52 interleukin 1 beta Rattus norvegicus 16-25 1641429-1 1992 Decrease in water intake after intraperitoneal injection of interleukin-1 beta (IL-1 beta) was studied in the rat. Water 12-17 interleukin 1 beta Rattus norvegicus 60-78 1641429-1 1992 Decrease in water intake after intraperitoneal injection of interleukin-1 beta (IL-1 beta) was studied in the rat. Water 12-17 interleukin 1 beta Rattus norvegicus 80-89 1641429-2 1992 Administration of IL-1 beta at a dose of 20 micrograms/kg attenuated osmotic thirst induced by intraperitoneal injection of hypertonic saline, but did not affect hypovolemic thirst induced by subcutaneous injection of either polyethylene glycol or angiotensin II. Sodium Chloride 124-141 interleukin 1 beta Rattus norvegicus 18-27 1641429-3 1992 Interleukin-1 beta also decreased spontaneous intake of water but not that of 1.8% saline. Water 56-61 interleukin 1 beta Rattus norvegicus 0-18 1641429-4 1992 The results suggest that the decrease in water intake by IL-1 beta is caused, at least in part, by suppression of osmotic thirst but not by general suppression of behavior. Water 41-46 interleukin 1 beta Rattus norvegicus 57-66 1641429-6 1992 Pretreatment with indomethacin blocked the decrease in water intake by IL-1 beta, suggesting the involvement of production of prostaglandins. Indomethacin 18-30 interleukin 1 beta Rattus norvegicus 71-80 1641429-6 1992 Pretreatment with indomethacin blocked the decrease in water intake by IL-1 beta, suggesting the involvement of production of prostaglandins. Water 55-60 interleukin 1 beta Rattus norvegicus 71-80 1641429-6 1992 Pretreatment with indomethacin blocked the decrease in water intake by IL-1 beta, suggesting the involvement of production of prostaglandins. Prostaglandins 126-140 interleukin 1 beta Rattus norvegicus 71-80 1374468-4 1992 Treatment of aortic rings without endothelium with interleukin-1 beta inhibited the contractions to phenylephrine by inducing nitric oxide synthase activity. Phenylephrine 100-113 interleukin 1 beta Rattus norvegicus 51-69 1577722-0 1992 Interleukin-1 beta- and forskolin-induced synthesis and secretion of group II phospholipase A2 and prostaglandin E2 in rat mesangial cells is prevented by transforming growth factor-beta 2. Dinoprostone 99-115 interleukin 1 beta Rattus norvegicus 0-19 1577722-1 1992 Interleukin-1 beta and forskolin induce prostaglandin E2 release as well as 14-kDa group II phospholipase A2 gene expression and secretion of the enzyme from rat glomerular mesangial cells. Dinoprostone 40-56 interleukin 1 beta Rattus norvegicus 0-18 1577722-2 1992 We now report that pretreatment of mesangial cells with transforming growth factor-beta 2 prior to stimulation with interleukin-1 beta or forskolin inhibits the induced release of prostaglandin E2. Dinoprostone 180-196 interleukin 1 beta Rattus norvegicus 116-134 1577722-8 1992 However, under conditions where the interleukin-1 beta-induced expression of group II phospholipase A2 is fully suppressed by transforming growth factor-beta 2, the growth factor itself stimulated prostaglandin E2 synthesis by a mechanism apparently not involving group II phospholipase A2. Dinoprostone 197-213 interleukin 1 beta Rattus norvegicus 36-54 1572315-6 1992 Comparable cellular densities of untreated or IL-1 beta-treated whole ovarian dispersates elaborated substantially more PGE2 as compared with isolated granulosa or theca-interstitial cell preparations suggesting a requirement for cell-cell interaction. Dinoprostone 120-124 interleukin 1 beta Rattus norvegicus 46-55 1572315-7 1992 Indeed, cell contact-dependent reconstitution experiments involving isolated granulosa and theca-interstitial cells at a projected physiologic ratio of 4:1 revealed synergistic interactions in the elaboration of PGE2 under both basal and IL-1 beta-treated circumstances. Dinoprostone 212-216 interleukin 1 beta Rattus norvegicus 238-247 1602386-0 1992 Reduction of aspirin-induced gastric damage in rats by interleukin-1 beta: possible involvement of endogenous corticosteroids. Aspirin 13-20 interleukin 1 beta Rattus norvegicus 55-73 1533363-3 1992 Islets that were exposed to rIL-1 beta for 48 h showed a 2.6-fold greater activity of mitochondrial manganese containing SOD (MnSOD) than control islets. Manganese 100-109 interleukin 1 beta Rattus norvegicus 28-38 1533363-4 1992 The cytosolic copper- and zinc-containing SOD (CuZnSOD) was, however, less affected by rIL-1 beta. Copper 14-20 interleukin 1 beta Rattus norvegicus 87-97 1533363-7 1992 The early induction of SOD by rIL-1 beta was inhibited by an interleukin-1 receptor antagonist protein and actinomycin-D, which is a blocker of gene transcription. Dactinomycin 107-120 interleukin 1 beta Rattus norvegicus 30-40 1374468-8 1992 The production of cyclic GMP evoked by interleukin-1 beta in rings without endothelium was inhibited by nitro L-arginine but not by calmidazolium. Cyclic GMP 18-28 interleukin 1 beta Rattus norvegicus 39-57 1374468-8 1992 The production of cyclic GMP evoked by interleukin-1 beta in rings without endothelium was inhibited by nitro L-arginine but not by calmidazolium. Nitroarginine 104-120 interleukin 1 beta Rattus norvegicus 39-57 1325229-2 1992 After 3 and 5 days of IL-1 beta infusion, the level of circulating ACTH was below the control level, while the plasma concentration of corticosterone was strikingly elevated. Corticosterone 135-149 interleukin 1 beta Rattus norvegicus 22-31 1533093-1 1992 Previous studies have indicated that interleukin-1 beta (IL-1) inhibits contraction of rat aortas by activating nitric oxide production in vascular smooth muscle cells, with subsequent increases in guanosine 3",5"-cyclic monophosphate (cGMP). Nitric Oxide 112-124 interleukin 1 beta Rattus norvegicus 37-55 1533093-1 1992 Previous studies have indicated that interleukin-1 beta (IL-1) inhibits contraction of rat aortas by activating nitric oxide production in vascular smooth muscle cells, with subsequent increases in guanosine 3",5"-cyclic monophosphate (cGMP). Cyclic GMP 198-234 interleukin 1 beta Rattus norvegicus 37-55 1533093-1 1992 Previous studies have indicated that interleukin-1 beta (IL-1) inhibits contraction of rat aortas by activating nitric oxide production in vascular smooth muscle cells, with subsequent increases in guanosine 3",5"-cyclic monophosphate (cGMP). Cyclic GMP 236-240 interleukin 1 beta Rattus norvegicus 37-55 1568479-4 1992 The glucocorticoid dexamethasone only partially suppressed the IL-1 beta- and forskolin-induced elevation of PLA2 mRNA, but totally inhibited PLA2 synthesis and secretion. Dexamethasone 19-32 interleukin 1 beta Rattus norvegicus 63-72 1563581-6 1992 Various polymer materials used in artificial membranes have been shown to activate macrophages involved in foreign body reactions and induce synthesis of interleukin-1 beta, a known Beta-cell toxin. Polymers 8-15 interleukin 1 beta Rattus norvegicus 154-172 1311232-12 1992 Similarly, IL-1 beta potentiated IL-6 release stimulated by forskolin and (Bu)2cAMP. Colforsin 60-69 interleukin 1 beta Rattus norvegicus 11-20 1560051-5 1992 Stimulation with Ionomycin plus repeated addition of DiC8 induced a low level of thymocyte proliferation and further addition of rIL-1 beta resulted in a significant increase. Ionomycin 17-26 interleukin 1 beta Rattus norvegicus 129-139 1378338-11 1992 Myocytes possessed Ca(2+)-dependent NO synthase activity and expressed, after treatment with tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), a Ca(2+)-independent NO synthase, the induction of which was prevented by dexamethasone and cycloheximide. Dexamethasone 244-257 interleukin 1 beta Rattus norvegicus 138-156 1378338-11 1992 Myocytes possessed Ca(2+)-dependent NO synthase activity and expressed, after treatment with tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), a Ca(2+)-independent NO synthase, the induction of which was prevented by dexamethasone and cycloheximide. Dexamethasone 244-257 interleukin 1 beta Rattus norvegicus 158-167 1378338-11 1992 Myocytes possessed Ca(2+)-dependent NO synthase activity and expressed, after treatment with tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), a Ca(2+)-independent NO synthase, the induction of which was prevented by dexamethasone and cycloheximide. Cycloheximide 262-275 interleukin 1 beta Rattus norvegicus 138-156 1378338-11 1992 Myocytes possessed Ca(2+)-dependent NO synthase activity and expressed, after treatment with tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), a Ca(2+)-independent NO synthase, the induction of which was prevented by dexamethasone and cycloheximide. Cycloheximide 262-275 interleukin 1 beta Rattus norvegicus 158-167 1311232-12 1992 Similarly, IL-1 beta potentiated IL-6 release stimulated by forskolin and (Bu)2cAMP. (bu)2camp 74-83 interleukin 1 beta Rattus norvegicus 11-20 1531861-0 1992 Nicotinamide partially reverses the interleukin-1 beta inhibition of glucose-induced insulin release in pancreatic islets. Niacinamide 0-12 interleukin 1 beta Rattus norvegicus 36-54 1564418-3 1992 As shown in this paper, fusidin also prevents the inhibitory effect of human recombinant IL-1 beta (rIL-1 beta) and the stimulatory effect of human rIL-6, on glucose-induced insulin production in vitro by normal rat pancreatic islets. Fusidic Acid 24-31 interleukin 1 beta Rattus norvegicus 100-110 1593469-19 1992 The present results suggest that IL-1 beta stimulates the release of prostaglandins, presumably E series, near regions of the hypothalamus, which act on the hypothalamus to induce activation of the sympathetic nervous system. Prostaglandins 69-83 interleukin 1 beta Rattus norvegicus 33-42 1564418-5 1992 Fusidin showed a dose-related effect at pharmacologically relevant concentrations from 3 to 30 micrograms/ml, and the drug was progressively less active when added 1, 4 and 24 h after rIL-1 beta. Fusidic Acid 0-7 interleukin 1 beta Rattus norvegicus 184-194 1564418-6 1992 Electron microscopical studies showed that beta cells cultured for 72 h with rIL-1 beta accumulated less lipid in the presence of fusidin, most probably reflecting the functionally protective effect of the drug. Fusidic Acid 130-137 interleukin 1 beta Rattus norvegicus 77-87 1564427-5 1992 Pretreatment with IL-1 beta increased plasma glucose levels 2 and 15 min after an i.v. Glucose 45-52 interleukin 1 beta Rattus norvegicus 18-27 1564427-7 1992 In the second group of experiments, dexamethasone supplement (0.1 mg/kg) given to adrenalectomized rats cancelled the reduction in plasma glucose levels by IL-1 beta, and rats treated with 1.0 mg dexamethasone/kg showed a significant increase in basal IRI levels and enhanced serum IRI levels after IL-1 beta injection. Dexamethasone 36-49 interleukin 1 beta Rattus norvegicus 156-165 1564427-7 1992 In the second group of experiments, dexamethasone supplement (0.1 mg/kg) given to adrenalectomized rats cancelled the reduction in plasma glucose levels by IL-1 beta, and rats treated with 1.0 mg dexamethasone/kg showed a significant increase in basal IRI levels and enhanced serum IRI levels after IL-1 beta injection. Dexamethasone 36-49 interleukin 1 beta Rattus norvegicus 299-308 1564427-7 1992 In the second group of experiments, dexamethasone supplement (0.1 mg/kg) given to adrenalectomized rats cancelled the reduction in plasma glucose levels by IL-1 beta, and rats treated with 1.0 mg dexamethasone/kg showed a significant increase in basal IRI levels and enhanced serum IRI levels after IL-1 beta injection. Dexamethasone 196-209 interleukin 1 beta Rattus norvegicus 299-308 1531861-0 1992 Nicotinamide partially reverses the interleukin-1 beta inhibition of glucose-induced insulin release in pancreatic islets. Glucose 69-76 interleukin 1 beta Rattus norvegicus 36-54 1531861-1 1992 Interleukin-1 beta (IL-1 beta) is known to inhibit glucose-induced insulin release by pancreatic islets. Glucose 51-58 interleukin 1 beta Rattus norvegicus 0-18 1531861-1 1992 Interleukin-1 beta (IL-1 beta) is known to inhibit glucose-induced insulin release by pancreatic islets. Glucose 51-58 interleukin 1 beta Rattus norvegicus 20-29 1531861-2 1992 We studied the effect of nicotinamide, an inhibitor of poly[adenosine diphosphate (ADP)-ribose] synthetase and a free-radical scavenger, on this IL-1 beta-induced inhibition using rat pancreatic islets. Niacinamide 25-37 interleukin 1 beta Rattus norvegicus 145-154 1531861-5 1992 Glucose-stimulated insulin secretion was significantly reduced (185 +/- 41) in IL-1 beta-exposed islets in comparison to control islets (2,037 +/- 363). Glucose 0-7 interleukin 1 beta Rattus norvegicus 79-88 1531861-6 1992 In parallel, arginine-stimulated insulin release was inhibited by IL-1 beta exposure (166 +/- 31 pg/islet/h, mean +/- SE, n = 3) in comparison to control islets (1,679 +/- 307). Arginine 13-21 interleukin 1 beta Rattus norvegicus 66-75 1531861-8 1992 When islets were simultaneously exposed to IL-1 beta and increasing concentrations of nicotinamide, a dose-dependent recovery of glucose-induced insulin secretion was observed, with the maximum effect at 25 mmol/L nicotinamide (1,007 +/- 123, P less than .001). Glucose 129-136 interleukin 1 beta Rattus norvegicus 43-52 1531861-8 1992 When islets were simultaneously exposed to IL-1 beta and increasing concentrations of nicotinamide, a dose-dependent recovery of glucose-induced insulin secretion was observed, with the maximum effect at 25 mmol/L nicotinamide (1,007 +/- 123, P less than .001). Niacinamide 214-226 interleukin 1 beta Rattus norvegicus 43-52 1536777-5 1992 Treatment with indomethacin could only abrogate the effects of nanogram doses of rIL-1 beta. Indomethacin 15-27 interleukin 1 beta Rattus norvegicus 81-91 1531337-1 1992 Acrylodan, which normally modifies cysteine residues, was employed to derivatize recombinant interleukin-1 beta (rIL-1 beta) under native conditions, using a reagent:protein ratio of 3:1. acrylodan 0-9 interleukin 1 beta Rattus norvegicus 113-123 1531337-10 1992 Thus, Cys-8 or Lys-103 modification of rIL-1 beta by acrylodan also does not interfere with the ability of the molecule to bind to its receptor. Cysteine 6-9 interleukin 1 beta Rattus norvegicus 39-49 1531337-10 1992 Thus, Cys-8 or Lys-103 modification of rIL-1 beta by acrylodan also does not interfere with the ability of the molecule to bind to its receptor. Lysine 15-18 interleukin 1 beta Rattus norvegicus 39-49 1531337-10 1992 Thus, Cys-8 or Lys-103 modification of rIL-1 beta by acrylodan also does not interfere with the ability of the molecule to bind to its receptor. acrylodan 53-62 interleukin 1 beta Rattus norvegicus 39-49 1729138-3 1992 Increased PGE2 was first detected 4 h after addition of rIL 1 beta to gels and was inhibited by 10(-5) M indomethacin. Dinoprostone 10-14 interleukin 1 beta Rattus norvegicus 56-66 1729138-3 1992 Increased PGE2 was first detected 4 h after addition of rIL 1 beta to gels and was inhibited by 10(-5) M indomethacin. Indomethacin 105-117 interleukin 1 beta Rattus norvegicus 56-66 1729138-4 1992 The amount of PGE2 synthesized per fibroblast increased with the time the gels had been in culture when stimulated with rIL 1 beta and was proportional to the number of fibroblasts in the gels, but inversely related to the collagen concentration. Dinoprostone 14-18 interleukin 1 beta Rattus norvegicus 120-130 1729138-6 1992 Exogenous 10(-4) M arachidonic acid further increased PGE2 synthesis by rIL 1 beta-stimulated fibroblasts, but the differential in the amount of PGE2 released from fibroblasts at high and low population densities in the gels was maintained. Arachidonic Acid 19-35 interleukin 1 beta Rattus norvegicus 72-82 1729138-6 1992 Exogenous 10(-4) M arachidonic acid further increased PGE2 synthesis by rIL 1 beta-stimulated fibroblasts, but the differential in the amount of PGE2 released from fibroblasts at high and low population densities in the gels was maintained. Dinoprostone 54-58 interleukin 1 beta Rattus norvegicus 72-82 1629818-1 1992 Ciprofloxacin, a new fluoroquinolone antibiotic, inhibits the in vitro production of interleukin 1 beta and tumor necrosis factor alpha by monocytes. Ciprofloxacin 0-13 interleukin 1 beta Rattus norvegicus 85-135 1309841-5 1992 In the present studies, IL-1 beta and TNF-alpha both inhibited 1,25-dihydroxyvitamin D3-stimulated production of osteocalcin protein and mRNA by ROS 17/2.8 osteosarcoma cells, whereas IL-6 had no effect on protein and only weakly inhibited mRNA. Calcitriol 63-87 interleukin 1 beta Rattus norvegicus 24-33 1309841-5 1992 In the present studies, IL-1 beta and TNF-alpha both inhibited 1,25-dihydroxyvitamin D3-stimulated production of osteocalcin protein and mRNA by ROS 17/2.8 osteosarcoma cells, whereas IL-6 had no effect on protein and only weakly inhibited mRNA. ros 145-148 interleukin 1 beta Rattus norvegicus 24-33 1309841-7 1992 After transient transfection of PHOC-CAT into ROS 17/2.8 osteosarcoma cells, reporter CAT activity was up-regulated by vitamin D at concentrations above 10(-12) M. In screening studies, TNF-alpha (-57%) and IL-6 (-37%) inhibited vitamin D-stimulated osteocalcin transcription, whereas IL-1 alpha, IL-1 beta, and IL-8 had no effect. Vitamin D 119-128 interleukin 1 beta Rattus norvegicus 297-306 1309841-9 1992 Despite their lack of promoter regulation, IL-1 alpha and IL-1 beta also stimulated PGE2 production by ROS 17/2.8, further confirming the ability of the host cell to respond to these mediators. Dinoprostone 84-88 interleukin 1 beta Rattus norvegicus 58-67 1309841-9 1992 Despite their lack of promoter regulation, IL-1 alpha and IL-1 beta also stimulated PGE2 production by ROS 17/2.8, further confirming the ability of the host cell to respond to these mediators. ros 103-106 interleukin 1 beta Rattus norvegicus 58-67 1629818-1 1992 Ciprofloxacin, a new fluoroquinolone antibiotic, inhibits the in vitro production of interleukin 1 beta and tumor necrosis factor alpha by monocytes. Fluoroquinolones 21-36 interleukin 1 beta Rattus norvegicus 85-135 1731791-7 1992 It is concluded that IL-1 beta in both rat and mouse islets induces nitric oxide formation and that this induction leads to the inhibition of the Krebs cycle enzyme aconitase. Nitric Oxide 68-80 interleukin 1 beta Rattus norvegicus 21-30 1370409-1 1992 Treatment of mesangial cells with interleukin 1 beta (IL-1 beta) or tumour necrosis factor alpha (TNF alpha) has been shown to increase cGMP formation, most probably due to induction of nitric oxide synthase. Cyclic GMP 136-140 interleukin 1 beta Rattus norvegicus 34-52 1370409-1 1992 Treatment of mesangial cells with interleukin 1 beta (IL-1 beta) or tumour necrosis factor alpha (TNF alpha) has been shown to increase cGMP formation, most probably due to induction of nitric oxide synthase. Cyclic GMP 136-140 interleukin 1 beta Rattus norvegicus 54-63 1370409-2 1992 Here we report that maximum stimulation of cGMP formation over a 24-h period required the presence of IL-1 beta or TNF alpha during the first 18 h of induction. Cyclic GMP 43-47 interleukin 1 beta Rattus norvegicus 102-111 1370409-6 1992 Furthermore, conditioned medium from IL-1 beta-treated cells increased cGMP in untreated control cells. Cyclic GMP 71-75 interleukin 1 beta Rattus norvegicus 37-46 1435088-6 1992 It is concluded that IL-1 beta inhibits the release of serotonin from the hypothalamus in vitro. Serotonin 55-64 interleukin 1 beta Rattus norvegicus 21-30 1581467-4 1992 Prior to the onset of IDDM in DP BB rats, high dose IL-1 beta induced leukocytosis (P less than 0.05), neutrophilia (P less than 0.01), and monocytosis (P less than 0.001). dp bb 30-35 interleukin 1 beta Rattus norvegicus 52-61 1478730-4 1992 Proenkephalin mRNA expression was stimulated by IL-1 beta in a time- and concentration-dependent manner, being maximal with 5 U/ml IL-1 beta at 4 h. Although the beta-adrenergic agonist isoproterenol was also active, interferon, glutamate, and carbachol were not. Isoproterenol 186-199 interleukin 1 beta Rattus norvegicus 48-57 1478730-4 1992 Proenkephalin mRNA expression was stimulated by IL-1 beta in a time- and concentration-dependent manner, being maximal with 5 U/ml IL-1 beta at 4 h. Although the beta-adrenergic agonist isoproterenol was also active, interferon, glutamate, and carbachol were not. Glutamic Acid 229-238 interleukin 1 beta Rattus norvegicus 48-57 1478730-4 1992 Proenkephalin mRNA expression was stimulated by IL-1 beta in a time- and concentration-dependent manner, being maximal with 5 U/ml IL-1 beta at 4 h. Although the beta-adrenergic agonist isoproterenol was also active, interferon, glutamate, and carbachol were not. Carbachol 244-253 interleukin 1 beta Rattus norvegicus 48-57 1478730-7 1992 These effects of IL-1 beta were region-specific, not being observed with either cerebellar or hippocampal astrocytes; however, isoproterenol was active in the latter cell populations. Isoproterenol 127-140 interleukin 1 beta Rattus norvegicus 17-26 1282951-1 1992 The present study investigated whether or not thrombin may affect the induction of nitric oxide (NO) synthase caused by interleukin-1 beta in cultured smooth muscle cells (SMCs) from the rat aorta. Nitric Oxide 83-95 interleukin 1 beta Rattus norvegicus 120-138 1282951-2 1992 The release of nitrite, an oxidation product of NO, from interleukin-1 beta-activated SMCs was inhibited by thrombin. Nitrites 15-22 interleukin 1 beta Rattus norvegicus 57-75 1282951-4 1992 Under bioassay conditions, the perfusate from interleukin-1 beta-activated SMCs relaxed endothelium-denuded rat aortic rings precontracted with phenylephrine. Phenylephrine 144-157 interleukin 1 beta Rattus norvegicus 46-64 1319228-5 1992 The results suggest that IL-1 beta mainly exerts a direct excitatory effect on SON neurons and further, that prostaglandins may be involved in such an effect. Prostaglandins 109-123 interleukin 1 beta Rattus norvegicus 25-34 1661096-0 1991 Platelet inhibition by an L-arginine-derived substance released by IL-1 beta-treated vascular smooth muscle cells. Arginine 26-36 interleukin 1 beta Rattus norvegicus 67-76 1319197-5 1992 (3) Local application of IL-1 beta and IFN alpha altered the activity of thermosensitive (TS) neurones and glucose responsive (GR) neurones in vitro in an appropriate way to produce fever and anorexia. Glucose 107-114 interleukin 1 beta Rattus norvegicus 25-34 1319197-6 1992 While the responses to IL-1 beta required the local release of prostaglandins, the responses to IFN alpha were found to be mediated by opioid receptor mechanisms. Prostaglandins 63-77 interleukin 1 beta Rattus norvegicus 23-32 1570409-2 1992 IL-1 beta strongly attenuated angiotensin-II (ANG-II, 10(-8) M)-stimulated ALDO secretion by both isolated zona glomerulosa (ZG) cells and capsular strips. Aldosterone 75-79 interleukin 1 beta Rattus norvegicus 0-9 1570409-4 1992 At the highest concentrations (10(-6)/10(-5) M), IL-1 beta was found to lower also basal ALDO output by isolated ZG cells, but not by capsular strips. Aldosterone 89-93 interleukin 1 beta Rattus norvegicus 49-58 1570409-5 1992 However, in the presence of saralasin 10(-8) M (a competitive inhibitor of ANG-II) and captopril 10(-8) M (an angiotensin-I-converting enzyme inhibitor), IL-1 beta significantly reduced basal ALDO yield of capsular strips. Captopril 87-96 interleukin 1 beta Rattus norvegicus 154-163 1661096-4 1991 This effect was potentiated by superoxide dismutase and reversed by incubating the IL-1 beta-treated smooth muscle cells with NG-nitro-L-arginine (L-NNA) or by treating the platelets with methylene blue. Nitroarginine 126-145 interleukin 1 beta Rattus norvegicus 83-92 1661096-4 1991 This effect was potentiated by superoxide dismutase and reversed by incubating the IL-1 beta-treated smooth muscle cells with NG-nitro-L-arginine (L-NNA) or by treating the platelets with methylene blue. Nitroarginine 147-152 interleukin 1 beta Rattus norvegicus 83-92 1661096-4 1991 This effect was potentiated by superoxide dismutase and reversed by incubating the IL-1 beta-treated smooth muscle cells with NG-nitro-L-arginine (L-NNA) or by treating the platelets with methylene blue. Methylene Blue 188-202 interleukin 1 beta Rattus norvegicus 83-92 1661096-6 1991 Incubating platelets with IL-1 beta-treated smooth muscle cells resulted in a 10-fold increase in platelet guanosine 3",5"-cyclic monophosphate (cGMP) levels, whereas untreated smooth muscle cells had no effect. Cyclic GMP 107-143 interleukin 1 beta Rattus norvegicus 26-35 1661096-6 1991 Incubating platelets with IL-1 beta-treated smooth muscle cells resulted in a 10-fold increase in platelet guanosine 3",5"-cyclic monophosphate (cGMP) levels, whereas untreated smooth muscle cells had no effect. Cyclic GMP 145-149 interleukin 1 beta Rattus norvegicus 26-35 1661096-7 1991 The elevation of platelet cGMP induced by the IL-1 beta-treated smooth muscle cells was prevented by exposing the cytokine-treated cells to L-NNA or by treating platelets with methylene blue. Cyclic GMP 26-30 interleukin 1 beta Rattus norvegicus 46-55 1661096-7 1991 The elevation of platelet cGMP induced by the IL-1 beta-treated smooth muscle cells was prevented by exposing the cytokine-treated cells to L-NNA or by treating platelets with methylene blue. Nitroarginine 140-145 interleukin 1 beta Rattus norvegicus 46-55 1661096-7 1991 The elevation of platelet cGMP induced by the IL-1 beta-treated smooth muscle cells was prevented by exposing the cytokine-treated cells to L-NNA or by treating platelets with methylene blue. Methylene Blue 176-190 interleukin 1 beta Rattus norvegicus 46-55 1661096-8 1991 Treatment of smooth muscle cells with IL-1 beta also resulted in an eightfold increase in nitrite production, which was blocked when the cells were incubated with L-NNA. Nitrites 90-97 interleukin 1 beta Rattus norvegicus 38-47 1661096-8 1991 Treatment of smooth muscle cells with IL-1 beta also resulted in an eightfold increase in nitrite production, which was blocked when the cells were incubated with L-NNA. Nitroarginine 163-168 interleukin 1 beta Rattus norvegicus 38-47 1661096-9 1991 The addition of cycloheximide to smooth muscle cells during their incubation with IL-1 beta completely inhibited smooth muscle cell nitrite production, the effects of the smooth muscle cells on platelet cGMP levels, and platelet responses to thrombin. Cycloheximide 16-29 interleukin 1 beta Rattus norvegicus 82-91 1661096-9 1991 The addition of cycloheximide to smooth muscle cells during their incubation with IL-1 beta completely inhibited smooth muscle cell nitrite production, the effects of the smooth muscle cells on platelet cGMP levels, and platelet responses to thrombin. Nitrites 132-139 interleukin 1 beta Rattus norvegicus 82-91 1720090-0 1991 Interleukin-1 beta-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. Nitric Oxide 27-39 interleukin 1 beta Rattus norvegicus 0-18 1720090-1 1991 The aim of this study was to characterize the dynamics and functional relevance of interleukin-1 beta (IL-1 beta)-induced nitric oxide production in isolated pancreatic islets. Nitric Oxide 122-134 interleukin 1 beta Rattus norvegicus 83-101 1720090-1 1991 The aim of this study was to characterize the dynamics and functional relevance of interleukin-1 beta (IL-1 beta)-induced nitric oxide production in isolated pancreatic islets. Nitric Oxide 122-134 interleukin 1 beta Rattus norvegicus 103-112 1720090-6 1991 Islet aconitase activity and glucose oxidation rates were decreased by 70% after incubation for 24 h with IL-1 beta. Glucose 29-36 interleukin 1 beta Rattus norvegicus 106-115 1720090-7 1991 Both Meth-arg and N alpha-p-tosyl-L-lysine chloromethyl ketone (0.1 mM), a protease inhibitor, could completely counteract the IL-1 beta-induced increases in nitrite production and inhibition of aconitase activity and glucose oxidation rates. omega-N-Methylarginine 5-13 interleukin 1 beta Rattus norvegicus 127-136 1720090-7 1991 Both Meth-arg and N alpha-p-tosyl-L-lysine chloromethyl ketone (0.1 mM), a protease inhibitor, could completely counteract the IL-1 beta-induced increases in nitrite production and inhibition of aconitase activity and glucose oxidation rates. n alpha-p-tosyl-l-lysine chloromethyl ketone 18-62 interleukin 1 beta Rattus norvegicus 127-136 1954875-4 1991 Incubation of these prelabeled cells with 25 ng/ml IL-1 beta caused an increase only within 1-2 min in the amount of free [3H]AA detected in the extracts of the cells. Tritium 123-125 interleukin 1 beta Rattus norvegicus 51-60 1954875-5 1991 During 15- to 30-min incubations, IL-1 beta (25 ng/ml) caused an increased accumulation of [3H]AA in the incubation medium which reached levels similar to those induced by 100 nM TRH. Tritium 92-94 interleukin 1 beta Rattus norvegicus 34-43 1954917-4 1991 To this end, use was made of a solution hybridization/RNase protection assay in which rat ovarian total RNA (20 micrograms) was hybridized with a [32P]-labeled 272 base rat IL-1 beta antisense riboprobe. Phosphorus-32 147-150 interleukin 1 beta Rattus norvegicus 173-182 1954875-6 1991 Perifused anterior pituitary cells responded to IL-1 beta (25 ng/ml) with a rapid (less than 2 min), biphasic, and reversible efflux of [3H]AA. Tritium 137-139 interleukin 1 beta Rattus norvegicus 48-57 1720090-7 1991 Both Meth-arg and N alpha-p-tosyl-L-lysine chloromethyl ketone (0.1 mM), a protease inhibitor, could completely counteract the IL-1 beta-induced increases in nitrite production and inhibition of aconitase activity and glucose oxidation rates. Nitrites 158-165 interleukin 1 beta Rattus norvegicus 127-136 1954875-11 1991 The PLA2 inhibitor aristolochic acid (10 microM) blocked IL-1 beta-induced IL-6 release and the release of IL-6 caused by Pyrularia pubera thionin (5 micrograms/ml), a stimulator of PLA2 activity. aristolochic acid I 19-36 interleukin 1 beta Rattus norvegicus 57-66 1720090-7 1991 Both Meth-arg and N alpha-p-tosyl-L-lysine chloromethyl ketone (0.1 mM), a protease inhibitor, could completely counteract the IL-1 beta-induced increases in nitrite production and inhibition of aconitase activity and glucose oxidation rates. Glucose 218-225 interleukin 1 beta Rattus norvegicus 127-136 1954875-13 1991 In contrast, the general lipoxygenase inhibitor nordihydroguaiaretic acid (10 microM) and the more specific 5-lipoxygenase inhibitors AA861 and RHC5901 (both 10 microM) reduced basal and blocked IL-1 beta-induced IL-6-release. Masoprocol 48-73 interleukin 1 beta Rattus norvegicus 195-204 1720090-9 1991 The presence of actinomycin-D during the 1-h IL-1 beta incubation period prevented the IL-1 beta-induced rise in nitrite production and the IL-1 beta-induced inhibition of aconitase activity and insulin release. Dactinomycin 16-29 interleukin 1 beta Rattus norvegicus 45-54 1954875-13 1991 In contrast, the general lipoxygenase inhibitor nordihydroguaiaretic acid (10 microM) and the more specific 5-lipoxygenase inhibitors AA861 and RHC5901 (both 10 microM) reduced basal and blocked IL-1 beta-induced IL-6-release. 2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone 134-139 interleukin 1 beta Rattus norvegicus 195-204 1720090-9 1991 The presence of actinomycin-D during the 1-h IL-1 beta incubation period prevented the IL-1 beta-induced rise in nitrite production and the IL-1 beta-induced inhibition of aconitase activity and insulin release. Dactinomycin 16-29 interleukin 1 beta Rattus norvegicus 87-96 1954875-13 1991 In contrast, the general lipoxygenase inhibitor nordihydroguaiaretic acid (10 microM) and the more specific 5-lipoxygenase inhibitors AA861 and RHC5901 (both 10 microM) reduced basal and blocked IL-1 beta-induced IL-6-release. RHC 5901 144-151 interleukin 1 beta Rattus norvegicus 195-204 1720090-9 1991 The presence of actinomycin-D during the 1-h IL-1 beta incubation period prevented the IL-1 beta-induced rise in nitrite production and the IL-1 beta-induced inhibition of aconitase activity and insulin release. Dactinomycin 16-29 interleukin 1 beta Rattus norvegicus 87-96 1720090-9 1991 The presence of actinomycin-D during the 1-h IL-1 beta incubation period prevented the IL-1 beta-induced rise in nitrite production and the IL-1 beta-induced inhibition of aconitase activity and insulin release. Nitrites 113-120 interleukin 1 beta Rattus norvegicus 45-54 1720090-9 1991 The presence of actinomycin-D during the 1-h IL-1 beta incubation period prevented the IL-1 beta-induced rise in nitrite production and the IL-1 beta-induced inhibition of aconitase activity and insulin release. Nitrites 113-120 interleukin 1 beta Rattus norvegicus 87-96 1720090-9 1991 The presence of actinomycin-D during the 1-h IL-1 beta incubation period prevented the IL-1 beta-induced rise in nitrite production and the IL-1 beta-induced inhibition of aconitase activity and insulin release. Nitrites 113-120 interleukin 1 beta Rattus norvegicus 87-96 1720090-10 1991 It is concluded that IL-1 beta-induced nitric oxide production is a late event which requires gene transcription and does not mediate the initial stimulatory effects of IL-1 beta on beta-cell function. Nitric Oxide 39-51 interleukin 1 beta Rattus norvegicus 21-30 1822555-25 1991 injection of PGE2 180 min after the injection of IL-1 beta caused a transient decrease in the rats" body temperature. Dinoprostone 13-17 interleukin 1 beta Rattus norvegicus 49-58 1756393-0 1991 Dexamethasone inhibits food intake suppression induced by low doses of interleukin-1 beta administered intracerebroventricularly. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 71-89 1936603-5 1991 However, when hsp70 liposome-incubated islets were further exposed to IL-1 beta (25 U/ml) for 16 h, these islets released more insulin in response to glucose stimulation and contained more insulin mRNA than islets incubated with control liposomes and subsequently exposed to the cytokine. Glucose 150-157 interleukin 1 beta Rattus norvegicus 70-79 1947795-11 1991 The route of administration was of importance for the biological effects of rIL-1 beta, as demonstrated by a reduced food intake, increased rectal temperature and blood glucose after s.c. injection of rIL-1 beta compared with i.p. Blood Glucose 163-176 interleukin 1 beta Rattus norvegicus 76-86 1686311-0 1991 Involvement of central beta-adrenoceptors in the induction of hypothalamic interleukin-1 beta mRNA by methamphetamine. Methamphetamine 102-117 interleukin 1 beta Rattus norvegicus 75-93 1686311-3 1991 The induction of IL-1 beta mRNA was blocked by intraperitoneal pretreatment with beta-blockers propranolol (0.1-1 mg/kg, but not 0.01 mg/kg) and pindolol (0.3 and 1 mg/kg). Propranolol 95-106 interleukin 1 beta Rattus norvegicus 17-26 1686311-3 1991 The induction of IL-1 beta mRNA was blocked by intraperitoneal pretreatment with beta-blockers propranolol (0.1-1 mg/kg, but not 0.01 mg/kg) and pindolol (0.3 and 1 mg/kg). Pindolol 145-153 interleukin 1 beta Rattus norvegicus 17-26 1686311-6 1991 ), propranolol, but neither prazosin nor yohimbine, significantly suppressed the methamphetamine-induced expression of IL-1 beta mRNA at a dose of 1 nmol/rat. Propranolol 3-14 interleukin 1 beta Rattus norvegicus 119-128 1686311-6 1991 ), propranolol, but neither prazosin nor yohimbine, significantly suppressed the methamphetamine-induced expression of IL-1 beta mRNA at a dose of 1 nmol/rat. Methamphetamine 81-96 interleukin 1 beta Rattus norvegicus 119-128 1686311-8 1991 injection of the beta-adrenoceptor agonist isoproterenol (1 and 3 micrograms/rat) dose-dependently increased the hypothalamic level of IL-1 beta mRNA. Isoproterenol 43-56 interleukin 1 beta Rattus norvegicus 135-144 1686311-9 1991 The present results suggest that the induction of hypothalamic IL-1 beta mRNA by methamphetamine is mediated by beta-adrenoceptors in the brain. Methamphetamine 81-96 interleukin 1 beta Rattus norvegicus 63-72 1717680-0 1991 Nitric oxide synthase inhibitors inhibit interleukin-1 beta-induced depression of vascular smooth muscle. Nitric Oxide 0-12 interleukin 1 beta Rattus norvegicus 41-59 1936271-1 1991 Treatment of rat mesangial cells with interleukin 1 beta (IL-1 beta) and forskolin greatly enhanced the expression of group II phospholipase A2 (PLA2) mRNA, with subsequent increased synthesis and secretion of PLA2, as detected by PLA2 activity measurements and immunoprecipitation of culture media of [35S]methionine-labelled mesangial cells. Sulfur-35 303-306 interleukin 1 beta Rattus norvegicus 38-56 1936271-1 1991 Treatment of rat mesangial cells with interleukin 1 beta (IL-1 beta) and forskolin greatly enhanced the expression of group II phospholipase A2 (PLA2) mRNA, with subsequent increased synthesis and secretion of PLA2, as detected by PLA2 activity measurements and immunoprecipitation of culture media of [35S]methionine-labelled mesangial cells. Sulfur-35 303-306 interleukin 1 beta Rattus norvegicus 58-67 1936271-1 1991 Treatment of rat mesangial cells with interleukin 1 beta (IL-1 beta) and forskolin greatly enhanced the expression of group II phospholipase A2 (PLA2) mRNA, with subsequent increased synthesis and secretion of PLA2, as detected by PLA2 activity measurements and immunoprecipitation of culture media of [35S]methionine-labelled mesangial cells. Methionine 307-317 interleukin 1 beta Rattus norvegicus 38-56 1936271-1 1991 Treatment of rat mesangial cells with interleukin 1 beta (IL-1 beta) and forskolin greatly enhanced the expression of group II phospholipase A2 (PLA2) mRNA, with subsequent increased synthesis and secretion of PLA2, as detected by PLA2 activity measurements and immunoprecipitation of culture media of [35S]methionine-labelled mesangial cells. Methionine 307-317 interleukin 1 beta Rattus norvegicus 58-67 1936271-4 1991 The tyrosine kinase inhibitor genistein dose-dependently antagonized the inhibitory effect of PDGF-BB on IL-1 beta-stimulated PLA2 secretion, thus suggesting that tyrosine phosphorylation may be required for PDGF-BB inhibition of PLA2 gene expression in mesangial cells. Genistein 30-39 interleukin 1 beta Rattus norvegicus 105-114 1936271-4 1991 The tyrosine kinase inhibitor genistein dose-dependently antagonized the inhibitory effect of PDGF-BB on IL-1 beta-stimulated PLA2 secretion, thus suggesting that tyrosine phosphorylation may be required for PDGF-BB inhibition of PLA2 gene expression in mesangial cells. Tyrosine 4-12 interleukin 1 beta Rattus norvegicus 105-114 1681735-2 1991 In the present study, the effects of IL-1 beta on pentagastrin-stimulated acid secretion were compared with those of two other cytokines, namely IL-1 alpha and tumor necrosis factor (TNF) alpha. Pentagastrin 50-62 interleukin 1 beta Rattus norvegicus 37-46 1681735-10 1991 These results demonstrate that IL-1 beta is an extremely potent inhibitor of acid secretion stimulated by pentagastrin but not that stimulated by histamine or bethanechol, through a mechanism that is at least in part independent of the vagus nerve and of prostaglandin synthesis. Pentagastrin 106-118 interleukin 1 beta Rattus norvegicus 31-40 1681735-10 1991 These results demonstrate that IL-1 beta is an extremely potent inhibitor of acid secretion stimulated by pentagastrin but not that stimulated by histamine or bethanechol, through a mechanism that is at least in part independent of the vagus nerve and of prostaglandin synthesis. Prostaglandins 255-268 interleukin 1 beta Rattus norvegicus 31-40 1659233-4 1991 ACTH response induced by IL-1 beta (15 micrograms/kg iv) was suppressed by pretreatment with injection of indomethacin (Indo), a potent inhibitor of prostaglandin (PG) synthesis, in a dose-dependent manner (1 and 10 mg/kg iv). Indomethacin 106-118 interleukin 1 beta Rattus norvegicus 25-34 1659233-4 1991 ACTH response induced by IL-1 beta (15 micrograms/kg iv) was suppressed by pretreatment with injection of indomethacin (Indo), a potent inhibitor of prostaglandin (PG) synthesis, in a dose-dependent manner (1 and 10 mg/kg iv). Indomethacin 120-124 interleukin 1 beta Rattus norvegicus 25-34 1659233-4 1991 ACTH response induced by IL-1 beta (15 micrograms/kg iv) was suppressed by pretreatment with injection of indomethacin (Indo), a potent inhibitor of prostaglandin (PG) synthesis, in a dose-dependent manner (1 and 10 mg/kg iv). Prostaglandins 149-162 interleukin 1 beta Rattus norvegicus 25-34 1659233-4 1991 ACTH response induced by IL-1 beta (15 micrograms/kg iv) was suppressed by pretreatment with injection of indomethacin (Indo), a potent inhibitor of prostaglandin (PG) synthesis, in a dose-dependent manner (1 and 10 mg/kg iv). Prostaglandins 164-166 interleukin 1 beta Rattus norvegicus 25-34 1659233-5 1991 Also, biphasic fever induced by the high dose of IL-1 beta was completely abolished by pretreatment with the intravenous injection of Indo. Indomethacin 134-138 interleukin 1 beta Rattus norvegicus 49-58 1930239-1 1991 We have previously described that treatment of rat glomerular mesangial cells with interleukin-1 beta, tumor necrosis factor or forskolin stimulates the synthesis and secretion of prostaglandin E2 and group II phospholipase A2. Dinoprostone 180-196 interleukin 1 beta Rattus norvegicus 83-101 1793014-2 1991 Cellular PLA2 activity increased 4-fold and production of PGE2 increased 3-fold at 1-2 hrs in the presence of 10 units/ml rIL-1 beta. Dinoprostone 58-62 interleukin 1 beta Rattus norvegicus 122-132 1655527-4 1991 It was found that IL-1 beta markedly decreased beta-cell DNA synthesis, insulin secretion and cyclic AMP content. Cyclic AMP 94-104 interleukin 1 beta Rattus norvegicus 18-27 1655527-5 1991 In order to explore whether the decrease in cAMP resulted from IL-1 beta interaction with GTP-binding proteins coupled to adenylyl cyclase, islets were treated for 24 h with pertussis toxin prior to addition of cytokine. Guanosine Triphosphate 90-93 interleukin 1 beta Rattus norvegicus 63-72 1655527-9 1991 The protease inhibitor N alpha-p-tosyl-L-lysine chloromethyl ketone, recently shown to protect completely against IL-1 beta-induced suppression of insulin production and secretion, was found to markedly reduce DNA synthesis without affecting insulin secretion. n alpha-p-tosyl-l-lysine chloromethyl ketone 23-67 interleukin 1 beta Rattus norvegicus 114-123 1655527-11 1991 It is concluded that cAMP stimulates DNA synthesis and insulin secretion in beta-cells, but that the inhibitory effect of IL-1 beta on these functions cannot be ascribed to the decrease in cAMP evoked by the cytokine. Cyclic AMP 189-193 interleukin 1 beta Rattus norvegicus 122-131 1959024-4 1991 The responses to IL-1 beta, but not to IFN alpha, were blocked by sodium salicylate, suggesting the involvement of synthesis of prostaglandins. Sodium Salicylate 66-83 interleukin 1 beta Rattus norvegicus 17-26 1932892-5 1991 Prostaglandin E2, Interleukin-1 beta, Tumor Necrosis Factor alpha and 1,25-dihydroxyvitamin D3 increased in general the production of both PA"s by all three cell types. Protactinium 139-141 interleukin 1 beta Rattus norvegicus 18-36 1959024-4 1991 The responses to IL-1 beta, but not to IFN alpha, were blocked by sodium salicylate, suggesting the involvement of synthesis of prostaglandins. Prostaglandins 128-142 interleukin 1 beta Rattus norvegicus 17-26 1933130-5 1991 Interleukin-1 (IL-1 beta; 5 micrograms) alone caused an increase in PGI2 metabolite excretion but had no effect on TXA2 metabolites. Epoprostenol 68-72 interleukin 1 beta Rattus norvegicus 15-24 1678697-3 1991 To investigate a possible hypothalamic action of the cytokines interleukin-1 beta (IL-1), interleukin-6, and tumor necrosis factor-alpha, on the release of GHRH and SRIH, we used a previously validated acute rat hypothalamic explant system. srih 165-169 interleukin 1 beta Rattus norvegicus 63-81 1916898-3 1991 Pre-treatment of the animals with dexamethasone (0.5 mg/kg, s.c.) or depletion of the peritoneal resident cell population abolished the neutrophil migration induced by rIL-8 and by recombinant interleukin-1 beta (rIL-1 beta). Dexamethasone 34-47 interleukin 1 beta Rattus norvegicus 193-211 1916898-3 1991 Pre-treatment of the animals with dexamethasone (0.5 mg/kg, s.c.) or depletion of the peritoneal resident cell population abolished the neutrophil migration induced by rIL-8 and by recombinant interleukin-1 beta (rIL-1 beta). Dexamethasone 34-47 interleukin 1 beta Rattus norvegicus 213-223 19912807-0 1991 In situ hybridization analysis of the induction of interleukin-1beta mRNA by methamphetamine in the rat hypothalamus. Methamphetamine 77-92 interleukin 1 beta Rattus norvegicus 51-68 1647309-0 1991 Interleukin-1 beta enhances corticosterone secretion by acting directly on the rat adrenal gland. Corticosterone 28-42 interleukin 1 beta Rattus norvegicus 0-18 1647309-3 1991 IL-1 beta was found to dose-dependently (4-8 micrograms/kg) raise corticosterone (B) blood concentration in hypophysectomized rats, without inducing any significant increase in the level of circulating ACTH. Corticosterone 66-80 interleukin 1 beta Rattus norvegicus 0-9 2036955-3 1991 IL-1 alpha and IL-1 beta (0.04-25 ng/ml) significantly increased IL-6 release 3- to 4-fold in a concentration-related manner during 6-h incubations; however, there was no change in extracellular or intracellular cAMP concentrations. Cyclic AMP 212-216 interleukin 1 beta Rattus norvegicus 15-24 2036955-5 1991 In the presence of VIP and PGE2, IL-1 alpha and IL-1 beta increased IL-6 release without any apparent further change in extracellular or intracellular cAMP. Dinoprostone 27-31 interleukin 1 beta Rattus norvegicus 48-57 2036955-9 1991 The synthetic glucocorticoid dexamethasone (10 nM) significantly inhibited IL-6 release induced by IL-1 alpha, IL-1 beta, or LPS. Dexamethasone 29-42 interleukin 1 beta Rattus norvegicus 111-120 1922954-0 1991 Methamphetamine-induced expression of interleukin-1 beta mRNA in the rat hypothalamus. Methamphetamine 0-15 interleukin 1 beta Rattus norvegicus 38-56 1922954-1 1991 The effect of methamphetamine on the expression of interleukin-1 beta (IL-1 beta) mRNA in the rat brain was investigated with Northern blot analysis. Methamphetamine 14-29 interleukin 1 beta Rattus norvegicus 51-69 1922954-1 1991 The effect of methamphetamine on the expression of interleukin-1 beta (IL-1 beta) mRNA in the rat brain was investigated with Northern blot analysis. Methamphetamine 14-29 interleukin 1 beta Rattus norvegicus 71-80 1922954-5 1991 These results provide the first evidence that methamphetamine induces the expression of IL-1 beta mRNA in the hypothalamus, which may be partly involved in the production of central actions of this drug. Methamphetamine 46-61 interleukin 1 beta Rattus norvegicus 88-97 1884236-0 1991 Interleukin-1 beta decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats. Acetylcholine 29-42 interleukin 1 beta Rattus norvegicus 0-18 1884236-3 1991 In the present experiment systemic injection of IL-1 beta (7.5-50 micrograms/kg) decreased extracellular acetylcholine in the hippocampus. Acetylcholine 105-118 interleukin 1 beta Rattus norvegicus 48-57 1868042-3 1991 The cytotoxic effects of rIL-1 beta beta were blocked by the simultaneous presence of a naturally occurring 6-9-kilodalton (kDa) inhibitor of IL-1-induced T-cell proliferation. 6-9-kilodalton 108-122 interleukin 1 beta Rattus norvegicus 25-35 19912807-1 1991 The induction of interleukin-1beta (IL-1beta) mRNA in the rat hypothalamus by systemic treatment with methamphetamine was studied using in situ hybridization. Methamphetamine 102-117 interleukin 1 beta Rattus norvegicus 17-34 19912807-1 1991 The induction of interleukin-1beta (IL-1beta) mRNA in the rat hypothalamus by systemic treatment with methamphetamine was studied using in situ hybridization. Methamphetamine 102-117 interleukin 1 beta Rattus norvegicus 36-44 19912807-2 1991 IL-1beta mRNA was expressed throughout the hypothalamus of methamphetamine-treated rats with no apparent signals in that of untreated rats; it was expressed in the paraventricular and periventricular hypothalamic nuclei, medial and lateral preoptic areas, lateral hypothalamic area, suprachiasmatic nucleus, dorsomedial and ventromedial hypothalamic nuclei, premammillary and supramammillary nucleus, median eminence, and arcuate nucleus. Methamphetamine 59-74 interleukin 1 beta Rattus norvegicus 0-8 19912807-4 1991 The induction of IL-1beta mRNA in these areas was suppressed by the beta-blocker propranolol (0.1 mg/kg, ip). Propranolol 81-92 interleukin 1 beta Rattus norvegicus 17-25 19912807-6 1991 The present results indicate that IL-1beta mRNA is widely expressed throughout the hypothalamus via beta-adrenoceptors, maybe in glial cells, following the treatment with methamphetamine and that IL-1beta might be involved in various hypothalamic functions induced by methamphetamine. Methamphetamine 171-186 interleukin 1 beta Rattus norvegicus 34-42 19912807-6 1991 The present results indicate that IL-1beta mRNA is widely expressed throughout the hypothalamus via beta-adrenoceptors, maybe in glial cells, following the treatment with methamphetamine and that IL-1beta might be involved in various hypothalamic functions induced by methamphetamine. Methamphetamine 268-283 interleukin 1 beta Rattus norvegicus 34-42 19912807-6 1991 The present results indicate that IL-1beta mRNA is widely expressed throughout the hypothalamus via beta-adrenoceptors, maybe in glial cells, following the treatment with methamphetamine and that IL-1beta might be involved in various hypothalamic functions induced by methamphetamine. Methamphetamine 268-283 interleukin 1 beta Rattus norvegicus 196-204 1708241-1 1991 The effect of interleukin-1 beta on the production of non-prostanoid vasoactive factors by cultured rat aortic smooth muscle cells was investigated. Prostaglandins 58-68 interleukin 1 beta Rattus norvegicus 14-32 1655471-1 1991 Contractions elicited by CaCl2 on isolated rat stomach strip preparations have been reported to be potentiated by interleukin-1 beta (IL-1 beta). Calcium Chloride 25-30 interleukin 1 beta Rattus norvegicus 114-132 1655471-1 1991 Contractions elicited by CaCl2 on isolated rat stomach strip preparations have been reported to be potentiated by interleukin-1 beta (IL-1 beta). Calcium Chloride 25-30 interleukin 1 beta Rattus norvegicus 134-143 1655471-4 1991 Both alpha MSH and its carboxyl terminal tripeptide concentration dependently reduced the potentiation of CaCl2-induced contractions caused by IL-1 beta but not those caused by leukotriene D4, the parent molecule being approximately 250 times more active. tripeptide K-26 41-51 interleukin 1 beta Rattus norvegicus 143-152 1655471-4 1991 Both alpha MSH and its carboxyl terminal tripeptide concentration dependently reduced the potentiation of CaCl2-induced contractions caused by IL-1 beta but not those caused by leukotriene D4, the parent molecule being approximately 250 times more active. Calcium Chloride 106-111 interleukin 1 beta Rattus norvegicus 143-152 1709015-0 1991 Effects of kainic acid on messenger RNA levels of IL-1 beta, IL-6, TNF alpha and LIF in the rat brain. Kainic Acid 11-22 interleukin 1 beta Rattus norvegicus 50-59 1709015-1 1991 We examined the kainic acid-induced changes of mRNA levels of several cytokines such as IL-1 beta, IL-6, TNF alpha and LIF in the rat brain regions using semiquantitative RT-PCR method. Kainic Acid 16-27 interleukin 1 beta Rattus norvegicus 88-97 1709015-2 1991 IL-1 beta mRNA was markedly increased in the cerebral cortex (CC), thalamus (THL) and hypothalamus (HT) 2 h after the injection of kainic acid in a convulsive dose (12 mg/kg i.p. Kainic Acid 131-142 interleukin 1 beta Rattus norvegicus 0-9 1708241-5 1991 Interleukin-1 beta (1 ng/ml) evoked a time-dependent accumulation of cyclic GMP but not cyclic AMP in cultured smooth muscle cells. Cyclic GMP 69-79 interleukin 1 beta Rattus norvegicus 0-18 1708241-6 1991 The transfer of fresh or stored (-70 degrees C) conditioned culture medium from interleukin-1 beta-treated cells but not from control cells, to cultured smooth muscle cells stimulated the production of cyclic GMP. Cyclic GMP 202-212 interleukin 1 beta Rattus norvegicus 80-98 1708241-7 1991 These observations demonstrate that interleukin-1 beta induces the production of transferable factor which relaxes vascular smooth muscle and stimulates the production of cyclic GMP. Cyclic GMP 171-181 interleukin 1 beta Rattus norvegicus 36-54 1712069-5 1991 125I-labeled human rIL-1 beta (15 kDa) was incubated with fresh normal human serum or with purified alpha 2M, treated or not with methylamine. methylamine 130-141 interleukin 1 beta Rattus norvegicus 19-29 1707535-10 1991 Treatment with a synthetic immunosuppressant glucocorticoid, dexamethasone, blocked the increase in SP after treatment with IL-1 beta. Dexamethasone 61-74 interleukin 1 beta Rattus norvegicus 124-133 2031444-0 1991 Repeated intraperitoneal injections of interleukin 1 beta induce glucose intolerance in normal rats. Glucose 65-72 interleukin 1 beta Rattus norvegicus 39-57 2031444-2 1991 The aims of the present study were to investigate the effects of single or repeated ip injections of recombinant IL-1 beta on blood glucose and glucose tolerance in vivo. Glucose 132-139 interleukin 1 beta Rattus norvegicus 113-122 2031444-6 1991 A single injection of rIL-1 beta caused a mild depression in blood glucose and an improved glucose tolerance. Glucose 67-74 interleukin 1 beta Rattus norvegicus 22-32 1712069-9 1991 The addition of D-penicillamine (D-pen) during the reaction of [125I]rIL-1 beta with serum or purified alpha 2M blocked the covalent binding of rIL-1 beta to alpha 2M. Penicillamine 16-31 interleukin 1 beta Rattus norvegicus 69-79 1712069-9 1991 The addition of D-penicillamine (D-pen) during the reaction of [125I]rIL-1 beta with serum or purified alpha 2M blocked the covalent binding of rIL-1 beta to alpha 2M. Penicillamine 16-31 interleukin 1 beta Rattus norvegicus 144-154 1712069-9 1991 The addition of D-penicillamine (D-pen) during the reaction of [125I]rIL-1 beta with serum or purified alpha 2M blocked the covalent binding of rIL-1 beta to alpha 2M. Penicillamine 16-21 interleukin 1 beta Rattus norvegicus 69-79 1712069-9 1991 The addition of D-penicillamine (D-pen) during the reaction of [125I]rIL-1 beta with serum or purified alpha 2M blocked the covalent binding of rIL-1 beta to alpha 2M. Penicillamine 16-21 interleukin 1 beta Rattus norvegicus 144-154 1712069-10 1991 [125I]rIL-1 beta was removed from alpha 2M by 2-mercaptoethanol in SDS. Mercaptoethanol 46-63 interleukin 1 beta Rattus norvegicus 6-16 1712069-10 1991 [125I]rIL-1 beta was removed from alpha 2M by 2-mercaptoethanol in SDS. Sodium Dodecyl Sulfate 67-70 interleukin 1 beta Rattus norvegicus 6-16 1712069-11 1991 Thus, disulfide bonds were formed between the free SH groups on [125I]rIL-1 beta and those resulting from the cleavage of the internal thioester bonds of alpha 2M. Disulfides 6-15 interleukin 1 beta Rattus norvegicus 70-80 1712069-13 1991 When complexes of rIL-1 beta or the mutant rIL-1 beta and alpha 2M were subjected to nonreducing SDS-PAGE and subsequent Western blot analysis, the rIL-1 beta molecules were found to be present in the alpha 2M bands in a dose-dependent manner. Sodium Dodecyl Sulfate 97-100 interleukin 1 beta Rattus norvegicus 18-28 1712069-13 1991 When complexes of rIL-1 beta or the mutant rIL-1 beta and alpha 2M were subjected to nonreducing SDS-PAGE and subsequent Western blot analysis, the rIL-1 beta molecules were found to be present in the alpha 2M bands in a dose-dependent manner. Sodium Dodecyl Sulfate 97-100 interleukin 1 beta Rattus norvegicus 43-53 1712069-13 1991 When complexes of rIL-1 beta or the mutant rIL-1 beta and alpha 2M were subjected to nonreducing SDS-PAGE and subsequent Western blot analysis, the rIL-1 beta molecules were found to be present in the alpha 2M bands in a dose-dependent manner. Sodium Dodecyl Sulfate 97-100 interleukin 1 beta Rattus norvegicus 43-53 1712069-14 1991 rIL-1 beta attached to alpha 2M in the presence or absence of D-pen showed similar biological activity in the mouse thymocyte-assay. Penicillamine 62-67 interleukin 1 beta Rattus norvegicus 0-10 1712069-17 1991 We concluded that human rIL-1 beta binds to alpha 2M through the Cys at position 8 and that D-pen inhibits this binding. Cysteine 65-68 interleukin 1 beta Rattus norvegicus 24-34 1712069-17 1991 We concluded that human rIL-1 beta binds to alpha 2M through the Cys at position 8 and that D-pen inhibits this binding. Penicillamine 92-97 interleukin 1 beta Rattus norvegicus 24-34 1996980-1 1991 The effects of intracisternal (ic) injection of recombinant interleukin-1 beta (IL-1) on absolute ethanol-induced gastric necrotic lesions were studied in conscious rats. Ethanol 98-105 interleukin 1 beta Rattus norvegicus 60-78 1908387-4 1991 17 ng/rat, injected into the third cerebroventricles significantly suppressed food intake and reduced the body weight gain in rats deprived of food for 18 h. Central administration of ibuprofen (IBP, 5-500 microgram/rat), a selective cyclooxygenase blocker, failed to attenuate the feeding suppression and body weight loss induced by IL-1 beta injection, although central administration of 50 microgram IBP blocked the increase of body temperature caused by central IL-1 beta. Ibuprofen 184-193 interleukin 1 beta Rattus norvegicus 334-343 1908387-4 1991 17 ng/rat, injected into the third cerebroventricles significantly suppressed food intake and reduced the body weight gain in rats deprived of food for 18 h. Central administration of ibuprofen (IBP, 5-500 microgram/rat), a selective cyclooxygenase blocker, failed to attenuate the feeding suppression and body weight loss induced by IL-1 beta injection, although central administration of 50 microgram IBP blocked the increase of body temperature caused by central IL-1 beta. Ibuprofen 184-193 interleukin 1 beta Rattus norvegicus 466-475 1908387-5 1991 The data obtained suggest that a peripheral prostaglandin synthesizing system may play an important role in the anorexia caused by IL-1 beta. Prostaglandins 44-57 interleukin 1 beta Rattus norvegicus 131-140 1648584-7 1991 The induction by rIL-1 beta was blocked by cycloheximide and dexamethasone. Cycloheximide 43-56 interleukin 1 beta Rattus norvegicus 17-27 1648584-7 1991 The induction by rIL-1 beta was blocked by cycloheximide and dexamethasone. Dexamethasone 61-74 interleukin 1 beta Rattus norvegicus 17-27 1993692-8 1991 Inhibiting protein synthesis with cycloheximide blocked the effect of rIL-1 beta on elastin mRNA levels. Cycloheximide 34-47 interleukin 1 beta Rattus norvegicus 70-80 1708236-3 1991 Here we report that transforming growth factor beta 2 (TGF beta 2) dose-dependently inhibits IL-1 beta- and TNF alpha-stimulated cGMP formation in mesangial cells. Cyclic GMP 129-133 interleukin 1 beta Rattus norvegicus 93-102 1884886-2 1991 We have hypothesized that interleukin 1 beta induces oxygen free radicals in Beta cells. oxygen free radicals 53-73 interleukin 1 beta Rattus norvegicus 26-44 1884886-3 1991 Since cytotoxicity induced by free radicals and by heat may activate the same cellular repair mechanism (the heat shock response), the aim of this study was to investigate the pattern of protein synthesis in isolated islets after exposure to interleukin 1 beta (150 pg/ml, 24 h), tumour necrosis factor alpha (50 ng/ml, 24 h) heat shock (43 degrees C, 30 min) and H2O2 (0.1 mmol/l, 20 min). Hydrogen Peroxide 364-368 interleukin 1 beta Rattus norvegicus 242-260 1884886-4 1991 By polyacrylamide gel electrophoresis, autoradiography, Western-blot analysis and partial peptide mapping of 35S-methionine labelled islets, interleukin 1 beta was found to induce a 73 kilodalton protein belonging to the heat shock protein family heat shock protein 70, a heat shock protein 90, and haem oxygenase. polyacrylamide 3-17 interleukin 1 beta Rattus norvegicus 141-159 1884886-4 1991 By polyacrylamide gel electrophoresis, autoradiography, Western-blot analysis and partial peptide mapping of 35S-methionine labelled islets, interleukin 1 beta was found to induce a 73 kilodalton protein belonging to the heat shock protein family heat shock protein 70, a heat shock protein 90, and haem oxygenase. Sulfur-35 109-112 interleukin 1 beta Rattus norvegicus 141-159 1884886-4 1991 By polyacrylamide gel electrophoresis, autoradiography, Western-blot analysis and partial peptide mapping of 35S-methionine labelled islets, interleukin 1 beta was found to induce a 73 kilodalton protein belonging to the heat shock protein family heat shock protein 70, a heat shock protein 90, and haem oxygenase. Methionine 113-123 interleukin 1 beta Rattus norvegicus 141-159 1675281-4 1991 However, when rat femoral head cartilage samples were incubated with 100 ng mL-1 rHu-IL-1 alpha or IL-1 beta for 5 days there was a significant increase in GAG loss from the cartilage into medium, whilst human synovial fluid significantly decreased the loss of GAG from rat cartilage into medium, compared with controls. Glycosaminoglycans 156-159 interleukin 1 beta Rattus norvegicus 99-108 1675281-4 1991 However, when rat femoral head cartilage samples were incubated with 100 ng mL-1 rHu-IL-1 alpha or IL-1 beta for 5 days there was a significant increase in GAG loss from the cartilage into medium, whilst human synovial fluid significantly decreased the loss of GAG from rat cartilage into medium, compared with controls. Glycosaminoglycans 261-264 interleukin 1 beta Rattus norvegicus 99-108 1671747-4 1991 Pretreatment with aspirin significantly attenuated the effects of interleukin-1 beta on both the vasopressin and oxytocin levels. Aspirin 18-25 interleukin 1 beta Rattus norvegicus 66-84 1846528-7 1991 Treatment with indomethacin completely inhibited IL-1 beta- and TNF-stimulated PGE2 synthesis, without having any effect on phospholipase A2 secretion, thus excluding cytokine-induced PGE2 synthesis as the mediator of phospholipase A2 release. Indomethacin 15-27 interleukin 1 beta Rattus norvegicus 49-58 1772965-9 1991 During repetitive as well as long-term (6 d) interleukin-1 beta exposure of islets, medium accumulation of glucagon was either increased or unaffected. Glucagon 107-115 interleukin 1 beta Rattus norvegicus 45-63 1782324-6 1991 When islets were exposed for 12 h to 50 U/ml rIL-1 beta in the presence of either an inhibitor of gene transcription (actinomycin D) or an inhibitor of mRNA translation (cycloheximide) there was a complete protection against the suppressive effects of rIL-1 beta on insulin release, (pro)insulin biosynthesis and insulin mRNA contents. Dactinomycin 118-131 interleukin 1 beta Rattus norvegicus 45-55 1991576-2 1991 It was found that the trypsin inhibitor N alpha-p-tosyl-L-lysine chloromethyl ketone (TLCK) counteracted the acute stimulatory effects of IL-1 beta on islet glucose oxidation, insulin release, and biosynthesis. n alpha-p-tosyl-l-lysine chloromethyl ketone 40-84 interleukin 1 beta Rattus norvegicus 138-147 1991576-2 1991 It was found that the trypsin inhibitor N alpha-p-tosyl-L-lysine chloromethyl ketone (TLCK) counteracted the acute stimulatory effects of IL-1 beta on islet glucose oxidation, insulin release, and biosynthesis. TLCK hydrochloride 86-90 interleukin 1 beta Rattus norvegicus 138-147 1991576-2 1991 It was found that the trypsin inhibitor N alpha-p-tosyl-L-lysine chloromethyl ketone (TLCK) counteracted the acute stimulatory effects of IL-1 beta on islet glucose oxidation, insulin release, and biosynthesis. Glucose 157-164 interleukin 1 beta Rattus norvegicus 138-147 1991576-3 1991 TLCK also partially or completely counteracted the long-term inhibitory effects of IL-1 beta on islet glucose oxidation, insulin biosynthesis, content, and release. Glucose 102-109 interleukin 1 beta Rattus norvegicus 83-92 1991576-5 1991 Of the other group-specific protease inhibitors investigated, only N-tosyl-L-phenylalanine chloromethyl ketone, N alpha-p-tosyl-L-arginine methyl ester, and chloromercuriphenylsulfonic acid were found to partially protect against IL-1 beta action. Tosylphenylalanyl Chloromethyl Ketone 67-110 interleukin 1 beta Rattus norvegicus 230-239 1903893-7 1991 Furthermore, IL-1 beta inhibited forskolin (10(-5) mmol/L) and (Bu)2 cAMP (10(-2) mmol/L)-stimulated estrogen production, indicating a post-cyclic AMP site of action. Colforsin 33-42 interleukin 1 beta Rattus norvegicus 13-22 1903893-7 1991 Furthermore, IL-1 beta inhibited forskolin (10(-5) mmol/L) and (Bu)2 cAMP (10(-2) mmol/L)-stimulated estrogen production, indicating a post-cyclic AMP site of action. Cyclic AMP 69-73 interleukin 1 beta Rattus norvegicus 13-22 1903893-7 1991 Furthermore, IL-1 beta inhibited forskolin (10(-5) mmol/L) and (Bu)2 cAMP (10(-2) mmol/L)-stimulated estrogen production, indicating a post-cyclic AMP site of action. Adenosine Monophosphate 70-73 interleukin 1 beta Rattus norvegicus 13-22 1846528-11 1991 The protein kinase inhibitors H-8, staurosporine, K252a and amiloride inhibited IL-1 beta- and TNF-stimulated phospholipase A2 secretion. Staurosporine 35-48 interleukin 1 beta Rattus norvegicus 80-89 1846528-11 1991 The protein kinase inhibitors H-8, staurosporine, K252a and amiloride inhibited IL-1 beta- and TNF-stimulated phospholipase A2 secretion. staurosporine aglycone 50-55 interleukin 1 beta Rattus norvegicus 80-89 1846528-11 1991 The protein kinase inhibitors H-8, staurosporine, K252a and amiloride inhibited IL-1 beta- and TNF-stimulated phospholipase A2 secretion. Amiloride 60-69 interleukin 1 beta Rattus norvegicus 80-89 1782324-6 1991 When islets were exposed for 12 h to 50 U/ml rIL-1 beta in the presence of either an inhibitor of gene transcription (actinomycin D) or an inhibitor of mRNA translation (cycloheximide) there was a complete protection against the suppressive effects of rIL-1 beta on insulin release, (pro)insulin biosynthesis and insulin mRNA contents. Cycloheximide 170-183 interleukin 1 beta Rattus norvegicus 45-55 1782324-6 1991 When islets were exposed for 12 h to 50 U/ml rIL-1 beta in the presence of either an inhibitor of gene transcription (actinomycin D) or an inhibitor of mRNA translation (cycloheximide) there was a complete protection against the suppressive effects of rIL-1 beta on insulin release, (pro)insulin biosynthesis and insulin mRNA contents. Cycloheximide 170-183 interleukin 1 beta Rattus norvegicus 252-262 1782324-7 1991 However, when islets were exposed for 2 h to rIL-1 beta in the presence of actinomycin D, and studied 12 h later, actinomycin counteracted the inhibitory effects of rIL-1 beta on insulin release, but not on (pro)insulin biosynthesis. Dactinomycin 75-88 interleukin 1 beta Rattus norvegicus 45-55 1782324-7 1991 However, when islets were exposed for 2 h to rIL-1 beta in the presence of actinomycin D, and studied 12 h later, actinomycin counteracted the inhibitory effects of rIL-1 beta on insulin release, but not on (pro)insulin biosynthesis. Dactinomycin 75-86 interleukin 1 beta Rattus norvegicus 45-55 1846528-7 1991 Treatment with indomethacin completely inhibited IL-1 beta- and TNF-stimulated PGE2 synthesis, without having any effect on phospholipase A2 secretion, thus excluding cytokine-induced PGE2 synthesis as the mediator of phospholipase A2 release. Dinoprostone 79-83 interleukin 1 beta Rattus norvegicus 49-58 1846528-10 1991 In addition, IL-1 beta and TNF synergistically interacted with forskolin to stimulate phospholipase A2 release from the cells. Colforsin 63-72 interleukin 1 beta Rattus norvegicus 13-22 1846528-11 1991 The protein kinase inhibitors H-8, staurosporine, K252a and amiloride inhibited IL-1 beta- and TNF-stimulated phospholipase A2 secretion. N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide 30-33 interleukin 1 beta Rattus norvegicus 80-89 1648453-1 1991 Intracerebroventricular (ICV) injections of interleukin-1 beta (IL-1 beta) produced a dose-dependent increase in plasma corticosterone and adrenocorticotropic hormone (ACTH) within 2 hr of injection and then declined over the next 24 hr. Corticosterone 120-134 interleukin 1 beta Rattus norvegicus 44-62 1648453-1 1991 Intracerebroventricular (ICV) injections of interleukin-1 beta (IL-1 beta) produced a dose-dependent increase in plasma corticosterone and adrenocorticotropic hormone (ACTH) within 2 hr of injection and then declined over the next 24 hr. Corticosterone 120-134 interleukin 1 beta Rattus norvegicus 64-73 1648453-2 1991 Using a potent steroidogenic dose of IL-1 beta (5 ng), ICV injection resulted in suppression of splenic macrophage IL-1 secretion following stimulation by LPS in vitro. icv 55-58 interleukin 1 beta Rattus norvegicus 37-46 1873492-8 1991 When we tested the additive effects on Sprague Dawley cells, increasing IL-1 beta concentrations added to a fixed IL-1 alpha concentration resulted in a cumulative rise in both, PGE2 secretion by MC and thymocyte proliferation. Dinoprostone 178-182 interleukin 1 beta Rattus norvegicus 72-81 1781305-3 1991 In newborn, but not in adult astrocytes, 100 U/ml of rIL-1 beta increase [3H]thymidine incorporation with a maximal response by 3 days as compared to the control untreated culture. Tritium 74-76 interleukin 1 beta Rattus norvegicus 53-63 1781305-3 1991 In newborn, but not in adult astrocytes, 100 U/ml of rIL-1 beta increase [3H]thymidine incorporation with a maximal response by 3 days as compared to the control untreated culture. Thymidine 77-86 interleukin 1 beta Rattus norvegicus 53-63 2086453-9 1990 However, the D-[6-14C]glucose oxidation rate, i.e., the metabolism of glucose in the Krebs cycle, was reduced by about 65% in rIL-1 beta exposed islets kept at 11.1 mM glucose and 46% in islets cultured at 56 mM glucose. Glucose 22-29 interleukin 1 beta Rattus norvegicus 126-136 1761361-2 1991 Intact or cyclophosphamide-treated mice received human rIL-1 beta according to different regimens, and their sera were assayed for CSA at 4, 24 or 48 h. The results indicated that (1) cyclophosphamide alone significantly increased the level of circulating CSA, (2) administration of IL-1 to intact or neutropenic mice resulted in a biphasic pattern of CSA response, an early burst at 4 h being followed at 24-48 h by a significant decrease. Cyclophosphamide 10-26 interleukin 1 beta Rattus norvegicus 55-65 1899119-1 1991 Human recombinant interleukin-1 beta (hrIL-1 beta) potentiated CaCl2-induced contractions of isolated stomach strip preparations from adrenalectomized rats (ADXSS). Calcium Chloride 63-68 interleukin 1 beta Rattus norvegicus 18-36 2046458-4 1991 The inhibitory effect of IL-1 beta icv administered on the occurrence of stress-induced gastric erosion was not influenced by icv administration of alpha-helical CRF(9-41), a corticotropin-releasing factor (CRF) receptor antagonist. icv 35-38 interleukin 1 beta Rattus norvegicus 25-34 2046458-5 1991 Indomethacin completely blocked the inhibitory action of IL-1 beta icv administered on stress-induced gastric erosion. Indomethacin 0-12 interleukin 1 beta Rattus norvegicus 57-66 2046458-6 1991 It is concluded from these results that IL-1 acts mainly in the central nervous system to inhibit the occurrence of stress-induced gastric erosion and that the IL-1 beta-induced inhibition of gastric erosion is mediated by prostaglandin in a manner that is independent of brain CRF. Prostaglandins 223-236 interleukin 1 beta Rattus norvegicus 160-169 1907704-1 1991 Interleukin-1 beta (IL-1 beta) at doses of 0.15 and 1.5 nM significantly inhibited FSH secretion and stimulated LH secretion by cultured rat pituitary cells after 24-72 hr incubation whereas 15 pM of IL-1 beta was not effective. Luteinizing Hormone 112-114 interleukin 1 beta Rattus norvegicus 0-18 1907704-1 1991 Interleukin-1 beta (IL-1 beta) at doses of 0.15 and 1.5 nM significantly inhibited FSH secretion and stimulated LH secretion by cultured rat pituitary cells after 24-72 hr incubation whereas 15 pM of IL-1 beta was not effective. Luteinizing Hormone 112-114 interleukin 1 beta Rattus norvegicus 20-29 1907704-3 1991 However, treatment with 0.15 and 1.5 nM of IL-1 beta for 72 hr significantly suppressed intracellular content of FSH whereas various doses of IL-1 beta incubated with the cells for 12-72 hr showed no effect on the intracellular content of LH. Luteinizing Hormone 239-241 interleukin 1 beta Rattus norvegicus 43-52 1907704-5 1991 The secretion of FSH and LH mediated by an activator of protein kinase C, phorbol 12-myristate 13-acetate, was also significantly suppressed by pretreatment with IL-1 beta for 48 hr. Tetradecanoylphorbol Acetate 74-105 interleukin 1 beta Rattus norvegicus 162-171 2265709-0 1990 Inhibition of insulin secretion by interleukin-1 beta and tumour necrosis factor-alpha via an L-arginine-dependent nitric oxide generating mechanism. Arginine 94-104 interleukin 1 beta Rattus norvegicus 35-86 2265709-0 1990 Inhibition of insulin secretion by interleukin-1 beta and tumour necrosis factor-alpha via an L-arginine-dependent nitric oxide generating mechanism. Nitric Oxide 115-127 interleukin 1 beta Rattus norvegicus 35-86 2265709-1 1990 Inhibition of glucose-induced insulin secretion by interleukin-1 beta (IL-1 beta), or IL-1 beta plus tumour necrosis factor-alpha (TNF-alpha), was less marked when rat islets of Langerhans were cultured for 12 h with these cytokines in L-arginine-free medium as opposed to medium containing L-arginine (1 mM). Glucose 14-21 interleukin 1 beta Rattus norvegicus 51-69 2265709-1 1990 Inhibition of glucose-induced insulin secretion by interleukin-1 beta (IL-1 beta), or IL-1 beta plus tumour necrosis factor-alpha (TNF-alpha), was less marked when rat islets of Langerhans were cultured for 12 h with these cytokines in L-arginine-free medium as opposed to medium containing L-arginine (1 mM). Glucose 14-21 interleukin 1 beta Rattus norvegicus 71-80 2265709-1 1990 Inhibition of glucose-induced insulin secretion by interleukin-1 beta (IL-1 beta), or IL-1 beta plus tumour necrosis factor-alpha (TNF-alpha), was less marked when rat islets of Langerhans were cultured for 12 h with these cytokines in L-arginine-free medium as opposed to medium containing L-arginine (1 mM). Arginine 236-246 interleukin 1 beta Rattus norvegicus 51-69 2265709-1 1990 Inhibition of glucose-induced insulin secretion by interleukin-1 beta (IL-1 beta), or IL-1 beta plus tumour necrosis factor-alpha (TNF-alpha), was less marked when rat islets of Langerhans were cultured for 12 h with these cytokines in L-arginine-free medium as opposed to medium containing L-arginine (1 mM). Arginine 236-246 interleukin 1 beta Rattus norvegicus 71-80 2265709-1 1990 Inhibition of glucose-induced insulin secretion by interleukin-1 beta (IL-1 beta), or IL-1 beta plus tumour necrosis factor-alpha (TNF-alpha), was less marked when rat islets of Langerhans were cultured for 12 h with these cytokines in L-arginine-free medium as opposed to medium containing L-arginine (1 mM). Arginine 291-301 interleukin 1 beta Rattus norvegicus 51-69 2265709-1 1990 Inhibition of glucose-induced insulin secretion by interleukin-1 beta (IL-1 beta), or IL-1 beta plus tumour necrosis factor-alpha (TNF-alpha), was less marked when rat islets of Langerhans were cultured for 12 h with these cytokines in L-arginine-free medium as opposed to medium containing L-arginine (1 mM). Arginine 291-301 interleukin 1 beta Rattus norvegicus 71-80 2265709-2 1990 Inhibition of secretion by IL-1 beta was further alleviated when islets were maintained in L-arginine-free medium supplemented with N-omega-nitro-L-arginine methyl ester (NAME), while synergism between IL-1 beta plus TNF-alpha was completely abolished. Arginine 91-101 interleukin 1 beta Rattus norvegicus 27-36 2265709-2 1990 Inhibition of secretion by IL-1 beta was further alleviated when islets were maintained in L-arginine-free medium supplemented with N-omega-nitro-L-arginine methyl ester (NAME), while synergism between IL-1 beta plus TNF-alpha was completely abolished. NG-Nitroarginine Methyl Ester 132-169 interleukin 1 beta Rattus norvegicus 27-36 2265709-2 1990 Inhibition of secretion by IL-1 beta was further alleviated when islets were maintained in L-arginine-free medium supplemented with N-omega-nitro-L-arginine methyl ester (NAME), while synergism between IL-1 beta plus TNF-alpha was completely abolished. NG-Nitroarginine Methyl Ester 171-175 interleukin 1 beta Rattus norvegicus 27-36 2265709-2 1990 Inhibition of secretion by IL-1 beta was further alleviated when islets were maintained in L-arginine-free medium supplemented with N-omega-nitro-L-arginine methyl ester (NAME), while synergism between IL-1 beta plus TNF-alpha was completely abolished. NG-Nitroarginine Methyl Ester 171-175 interleukin 1 beta Rattus norvegicus 202-211 2265709-3 1990 Tissue culture medium nitrite levels were raised in islets treated with IL-1 beta or TNF-alpha (48 h). Nitrites 22-29 interleukin 1 beta Rattus norvegicus 72-81 2265709-5 1990 In conclusion, an L-arginine-dependent nitric oxide generating mechanism is involved in the inhibition of insulin secretion by IL-1 beta, and accounts for the phenomenon of synergism between IL-1 beta and TNF-alpha. Arginine 18-28 interleukin 1 beta Rattus norvegicus 127-136 2265709-5 1990 In conclusion, an L-arginine-dependent nitric oxide generating mechanism is involved in the inhibition of insulin secretion by IL-1 beta, and accounts for the phenomenon of synergism between IL-1 beta and TNF-alpha. Arginine 18-28 interleukin 1 beta Rattus norvegicus 191-200 2265709-5 1990 In conclusion, an L-arginine-dependent nitric oxide generating mechanism is involved in the inhibition of insulin secretion by IL-1 beta, and accounts for the phenomenon of synergism between IL-1 beta and TNF-alpha. Nitric Oxide 39-51 interleukin 1 beta Rattus norvegicus 127-136 2265709-5 1990 In conclusion, an L-arginine-dependent nitric oxide generating mechanism is involved in the inhibition of insulin secretion by IL-1 beta, and accounts for the phenomenon of synergism between IL-1 beta and TNF-alpha. Nitric Oxide 39-51 interleukin 1 beta Rattus norvegicus 191-200 2076859-5 1990 PGF2 alpha may be involved in the thermogenic actions of interleukin-1 beta which is also a potent thermogenic agent acting via CRF. Dinoprost 0-4 interleukin 1 beta Rattus norvegicus 57-75 2046458-2 1991 The intracerebroventricular (icv) administration of IL-1 beta significantly inhibited the occurrence of water-immersion restraint stress-induced gastric erosion at doses of 200 ng, 500 ng and 1 microgram, whereas the intravenous (iv) administration of IL-1 beta altered the occurrence of gastric erosion only at a dose of 1 microgram. Water 104-109 interleukin 1 beta Rattus norvegicus 52-61 1997793-4 1991 In contrast, treatment with 50 ng of IL-1 beta produced substantial reductions in these decreases, and treatment with 100 ng of IL-1 beta produced increases of up to 118% and 89% in the release rates of DA and DOPAC, respectively. Dopamine 203-205 interleukin 1 beta Rattus norvegicus 128-137 1997793-4 1991 In contrast, treatment with 50 ng of IL-1 beta produced substantial reductions in these decreases, and treatment with 100 ng of IL-1 beta produced increases of up to 118% and 89% in the release rates of DA and DOPAC, respectively. 3,4-Dihydroxyphenylacetic Acid 210-215 interleukin 1 beta Rattus norvegicus 128-137 1997793-5 1991 It is concluded that IL-1 beta affects the metabolism of catecholamines (and probably other neurotransmitters) in the brain, which, in turn, mediate its central and neuroendocrine actions. Catecholamines 57-71 interleukin 1 beta Rattus norvegicus 21-30 1646737-9 1991 Furthermore, IL-1 beta caused a significant inhibition of cAMP production in Sertoli cells and did not influence dibutyryl-cAMP-stimulated aromatase activity under identical experimental conditions. Cyclic AMP 58-62 interleukin 1 beta Rattus norvegicus 13-22 2086453-2 1990 Rat pancreatic islets exposed to human recombinant IL-1 beta (rIL-1 beta) for 48 h in vitro exhibit a markedly reduced glucose-stimulated insulin secretion. Glucose 119-126 interleukin 1 beta Rattus norvegicus 62-72 2086453-9 1990 However, the D-[6-14C]glucose oxidation rate, i.e., the metabolism of glucose in the Krebs cycle, was reduced by about 65% in rIL-1 beta exposed islets kept at 11.1 mM glucose and 46% in islets cultured at 56 mM glucose. d-[6-14c]glucose 13-29 interleukin 1 beta Rattus norvegicus 126-136 2086453-9 1990 However, the D-[6-14C]glucose oxidation rate, i.e., the metabolism of glucose in the Krebs cycle, was reduced by about 65% in rIL-1 beta exposed islets kept at 11.1 mM glucose and 46% in islets cultured at 56 mM glucose. krebs 85-90 interleukin 1 beta Rattus norvegicus 126-136 2086453-9 1990 However, the D-[6-14C]glucose oxidation rate, i.e., the metabolism of glucose in the Krebs cycle, was reduced by about 65% in rIL-1 beta exposed islets kept at 11.1 mM glucose and 46% in islets cultured at 56 mM glucose. Glucose 70-77 interleukin 1 beta Rattus norvegicus 126-136 2086453-9 1990 However, the D-[6-14C]glucose oxidation rate, i.e., the metabolism of glucose in the Krebs cycle, was reduced by about 65% in rIL-1 beta exposed islets kept at 11.1 mM glucose and 46% in islets cultured at 56 mM glucose. Glucose 70-77 interleukin 1 beta Rattus norvegicus 126-136 2086454-5 1990 In these experiments rIL-1 beta induced an increase both in net cellular uptake of calcium and in insulin release only in the presence of 16.7 mM glucose. Calcium 83-90 interleukin 1 beta Rattus norvegicus 21-31 2086454-5 1990 In these experiments rIL-1 beta induced an increase both in net cellular uptake of calcium and in insulin release only in the presence of 16.7 mM glucose. Glucose 146-153 interleukin 1 beta Rattus norvegicus 21-31 2086454-6 1990 The stimulatory effect of rIL-1 beta at 16.7 mM glucose was blocked by verapamil. Glucose 48-55 interleukin 1 beta Rattus norvegicus 26-36 2086454-6 1990 The stimulatory effect of rIL-1 beta at 16.7 mM glucose was blocked by verapamil. Verapamil 71-80 interleukin 1 beta Rattus norvegicus 26-36 2086454-8 1990 During the first 2 h of incubation 25 U/ml rIL-1 beta effected a significant increase of net calcium uptake, insulin release and glucose oxidation. Calcium 93-100 interleukin 1 beta Rattus norvegicus 43-53 2086454-8 1990 During the first 2 h of incubation 25 U/ml rIL-1 beta effected a significant increase of net calcium uptake, insulin release and glucose oxidation. Glucose 129-136 interleukin 1 beta Rattus norvegicus 43-53 2226323-2 1990 This inhibition was probably due to a central effect, since IL-1 alpha and IL-1 beta also suppressed the in vitro LHRH output from the hypothalami of steroid-primed ovx rats. Steroids 150-157 interleukin 1 beta Rattus norvegicus 75-84 2264829-4 1990 A 12 h pretreatment of islets with tumour necrosis factor-alpha (TNF-alpha) combined with IL-1 beta potentiated the inhibitory effect of IL-1 beta on secretion, such that 20 mM-glucose-induced insulin secretion was abolished. Glucose 176-184 interleukin 1 beta Rattus norvegicus 90-99 2264829-4 1990 A 12 h pretreatment of islets with tumour necrosis factor-alpha (TNF-alpha) combined with IL-1 beta potentiated the inhibitory effect of IL-1 beta on secretion, such that 20 mM-glucose-induced insulin secretion was abolished. Glucose 176-184 interleukin 1 beta Rattus norvegicus 137-146 2226323-7 1990 NAL infusion into control SAL-injected rats did not alter the LH surge; however, it reversed the IL-1 alpha- and IL-1 beta-induced suppression of the LH surge. Naloxone 0-3 interleukin 1 beta Rattus norvegicus 113-122 2226323-11 1990 These results suggest that IL-1 alpha and IL-1 beta inhibit LHRH-LH release by stimulating the activity of hypothalamic endogenous opioid peptide systems. Luteinizing Hormone 60-62 interleukin 1 beta Rattus norvegicus 42-51 2118724-4 1990 rIL-1 beta increased [3H]thymidine uptake in MC by approximately 70% after 48 h. This growth-promoting activity of the cytokine was observed at 1 ng/ml and was not further enhanced by the increase of the IL-1 beta concentration less than or equal to 100-fold. Tritium 22-24 interleukin 1 beta Rattus norvegicus 0-10 2171909-0 1990 The adrenocorticotropin response to interleukin-1 beta instilled into the rat median eminence depends on the local release of catecholamines. Catecholamines 126-140 interleukin 1 beta Rattus norvegicus 36-54 2289528-1 1990 Interleukin-1 beta (IL-1 beta) has been reported to stimulate prostaglandin synthesis by the rat stomach in vitro and to inhibit gastric acid secretion in vivo. Prostaglandins 62-75 interleukin 1 beta Rattus norvegicus 20-29 2289528-3 1990 IL-1 beta, given i.p., dose and time dependently reduced the severity of ethanol-induced gastric damage. Ethanol 73-80 interleukin 1 beta Rattus norvegicus 0-9 2289528-5 1990 The protective actions of IL-1 beta were abolished by prior boiling or by pretreatment of the animals with indomethacin, and were not shared by the nonapeptide fragment 163-171. Indomethacin 107-119 interleukin 1 beta Rattus norvegicus 26-35 2289528-6 1990 IL-1 beta also reduced the severity of gastric damage induced by indomethacin and the duodenal ulceration induced by cysteamine. Indomethacin 65-77 interleukin 1 beta Rattus norvegicus 0-9 2289528-6 1990 IL-1 beta also reduced the severity of gastric damage induced by indomethacin and the duodenal ulceration induced by cysteamine. Cysteamine 117-127 interleukin 1 beta Rattus norvegicus 0-9 1698365-1 1990 The effects of systemic administration of kainic acid and pentylenetetrazol on interleukin-1 beta gene expression in the rat brain was studied. Kainic Acid 42-53 interleukin 1 beta Rattus norvegicus 79-97 1698365-1 1990 The effects of systemic administration of kainic acid and pentylenetetrazol on interleukin-1 beta gene expression in the rat brain was studied. Pentylenetetrazole 58-75 interleukin 1 beta Rattus norvegicus 79-97 1698365-4 1990 Pentylenetetrazol induced Interleukin-1 beta mRNA in the cerebral cortex, hypothalamus, and hippocampus with a faster time-course than kainic acid. Pentylenetetrazole 0-17 interleukin 1 beta Rattus norvegicus 26-44 1698365-5 1990 Diazepam suppressed both the convulsion and the induction of Interleukin-1 beta mRNA produced by kainic acid. Diazepam 0-8 interleukin 1 beta Rattus norvegicus 61-79 1698365-5 1990 Diazepam suppressed both the convulsion and the induction of Interleukin-1 beta mRNA produced by kainic acid. Kainic Acid 97-108 interleukin 1 beta Rattus norvegicus 61-79 1698365-6 1990 Dexamethasone suppressed the induction of Interleukin-1 beta mRNA, but did neither the convulsion nor the induction of c-fos mRNA following the injection of kainic acid. Dexamethasone 0-13 interleukin 1 beta Rattus norvegicus 42-60 2171909-7 1990 Moreover, in rats given iv IL-1 beta (1 microgram), 6-hydroxy-dopamine significantly reduced the ACTH response by more than 50% (P less than 0.001). Oxidopamine 52-70 interleukin 1 beta Rattus norvegicus 27-36 2171909-13 1990 In contrast, a significant (P less than 0.01) dose-dependent reduction in the ACTH response to intra-ME IL-1 beta (30 ng) was observed in rats pretreated with either a nonselective alpha or beta adrenoreceptor antagonist (phentolamine, 2-40 micrograms or propranolol, 2-20 micrograms, respectively, into the ME). Phentolamine 222-234 interleukin 1 beta Rattus norvegicus 104-113 2171909-13 1990 In contrast, a significant (P less than 0.01) dose-dependent reduction in the ACTH response to intra-ME IL-1 beta (30 ng) was observed in rats pretreated with either a nonselective alpha or beta adrenoreceptor antagonist (phentolamine, 2-40 micrograms or propranolol, 2-20 micrograms, respectively, into the ME). Propranolol 255-266 interleukin 1 beta Rattus norvegicus 104-113 2171909-15 1990 Thus, the secretion of ACTH stimulated by the action of IL-1 beta at the ME depends, in part, on the local secretion of norepinephrine and epinephrine interacting with both alpha and beta adrenergic receptors. Norepinephrine 120-134 interleukin 1 beta Rattus norvegicus 56-65 2171909-15 1990 Thus, the secretion of ACTH stimulated by the action of IL-1 beta at the ME depends, in part, on the local secretion of norepinephrine and epinephrine interacting with both alpha and beta adrenergic receptors. Epinephrine 123-134 interleukin 1 beta Rattus norvegicus 56-65 2171911-3 1990 In all groups and at the various rIL-1 beta concentrations tested, there was a similar 30-50% inhibition in glucose-induced insulin release, a 70-80% decrease in islet insulin content, and no significant differences in islet DNA content or insulin accumulation in the culture medium. Glucose 108-115 interleukin 1 beta Rattus norvegicus 33-43 2097573-8 1990 applied IL-1 beta on gastric acid secretion was completely abolished in indomethacin-pretreated animals but not in reserpine-pretreated ones. Indomethacin 72-84 interleukin 1 beta Rattus norvegicus 8-17 2289528-1 1990 Interleukin-1 beta (IL-1 beta) has been reported to stimulate prostaglandin synthesis by the rat stomach in vitro and to inhibit gastric acid secretion in vivo. Prostaglandins 62-75 interleukin 1 beta Rattus norvegicus 0-18 2205515-3 1990 IL-1 beta stimulated 3-O-methylglucose (3OMG) transport in a time and dose dependent manner. 3-O-Methylglucose 21-38 interleukin 1 beta Rattus norvegicus 0-9 2205515-3 1990 IL-1 beta stimulated 3-O-methylglucose (3OMG) transport in a time and dose dependent manner. 3-O-Methylglucose 40-44 interleukin 1 beta Rattus norvegicus 0-9 2118724-4 1990 rIL-1 beta increased [3H]thymidine uptake in MC by approximately 70% after 48 h. This growth-promoting activity of the cytokine was observed at 1 ng/ml and was not further enhanced by the increase of the IL-1 beta concentration less than or equal to 100-fold. Tritium 22-24 interleukin 1 beta Rattus norvegicus 1-10 2118724-4 1990 rIL-1 beta increased [3H]thymidine uptake in MC by approximately 70% after 48 h. This growth-promoting activity of the cytokine was observed at 1 ng/ml and was not further enhanced by the increase of the IL-1 beta concentration less than or equal to 100-fold. Thymidine 25-34 interleukin 1 beta Rattus norvegicus 0-10 2118724-4 1990 rIL-1 beta increased [3H]thymidine uptake in MC by approximately 70% after 48 h. This growth-promoting activity of the cytokine was observed at 1 ng/ml and was not further enhanced by the increase of the IL-1 beta concentration less than or equal to 100-fold. Thymidine 25-34 interleukin 1 beta Rattus norvegicus 1-10 2118724-5 1990 IL-1 beta, however, dose dependently stimulated prostaglandin E2 (PGE2) formation by MC. Dinoprostone 48-64 interleukin 1 beta Rattus norvegicus 0-9 2118724-5 1990 IL-1 beta, however, dose dependently stimulated prostaglandin E2 (PGE2) formation by MC. Dinoprostone 66-70 interleukin 1 beta Rattus norvegicus 0-9 2118724-6 1990 When prostaglandin synthesis was inhibited by indomethacin (Indo, 1 microgram/ml), rIL-1 beta (10 ng/ml)-induced cell proliferation was sevenfold greater compared with rIL-1 beta alone. Prostaglandins 5-18 interleukin 1 beta Rattus norvegicus 83-93 2118724-6 1990 When prostaglandin synthesis was inhibited by indomethacin (Indo, 1 microgram/ml), rIL-1 beta (10 ng/ml)-induced cell proliferation was sevenfold greater compared with rIL-1 beta alone. Prostaglandins 5-18 interleukin 1 beta Rattus norvegicus 168-178 2118724-6 1990 When prostaglandin synthesis was inhibited by indomethacin (Indo, 1 microgram/ml), rIL-1 beta (10 ng/ml)-induced cell proliferation was sevenfold greater compared with rIL-1 beta alone. Indomethacin 46-58 interleukin 1 beta Rattus norvegicus 83-93 2118724-6 1990 When prostaglandin synthesis was inhibited by indomethacin (Indo, 1 microgram/ml), rIL-1 beta (10 ng/ml)-induced cell proliferation was sevenfold greater compared with rIL-1 beta alone. Indomethacin 46-58 interleukin 1 beta Rattus norvegicus 168-178 2118724-6 1990 When prostaglandin synthesis was inhibited by indomethacin (Indo, 1 microgram/ml), rIL-1 beta (10 ng/ml)-induced cell proliferation was sevenfold greater compared with rIL-1 beta alone. Indomethacin 60-64 interleukin 1 beta Rattus norvegicus 83-93 2118724-7 1990 In the presence of Indo (1 microgram/ml), rIL-1 beta (1, 10, 50, and 100 ng/ml) dose dependently stimulated MC proliferation. Indomethacin 19-23 interleukin 1 beta Rattus norvegicus 42-52 2118724-8 1990 The addition of exogenous PGE2 (10(-7) and 10(-8) M) to Indo-treated MC blocked the mitogenic response of IL-1 beta. Dinoprostone 26-30 interleukin 1 beta Rattus norvegicus 106-115 2118724-8 1990 The addition of exogenous PGE2 (10(-7) and 10(-8) M) to Indo-treated MC blocked the mitogenic response of IL-1 beta. Indomethacin 56-60 interleukin 1 beta Rattus norvegicus 106-115 2118724-9 1990 We conclude that endogenous PGE2 formation, which is stimulated by IL-1 beta, antagonizes the growth-promoting activity of the cytokine. Dinoprostone 28-32 interleukin 1 beta Rattus norvegicus 67-76 2174528-4 1990 Once the residual hypersensitivity had been abolished with dipyrone or N-methyl morphine, a small dose of prostaglandin E2, dopamine or Interleukin-1 beta, which in normal animals causes a mild and short lived effect, restored the persistent hypersensitive state. Dipyrone 59-67 interleukin 1 beta Rattus norvegicus 136-154 2228412-6 1990 These data suggest that impaired responses to IL-1 beta in obese mutants may be due to inhibitory actions of glucocorticoids on either prostaglandin synthesis or CRF release within the hypothalamus. Prostaglandins 135-148 interleukin 1 beta Rattus norvegicus 46-55 2202741-4 1990 Maximal inhibition was achieved by incubation of cells with 100 ng/ml of rIL-1 beta or 5 ng/ml of rTNF alpha for 12-24 hours, resulting in a reduction of the synthesis of heparan sulfate on the cell surface by approximately 50%. Heparitin Sulfate 171-186 interleukin 1 beta Rattus norvegicus 73-83 2115435-7 1990 In gonadectomized animals, 2.5 and 10 ng Il-1 beta administered icv significantly (P less than or equal to 0.01) decreased plasma LH levels for 6 h, while the effect of 40 ng lasted up to 12 h. By contrast, FSH secretion was only measurably altered by 40 ng Il-1 beta 8 and 12 h posttreatment. Luteinizing Hormone 130-132 interleukin 1 beta Rattus norvegicus 41-50 2396988-0 1990 Transforming growth factor beta 2 differentially modulates interleukin-1 beta- and tumour-necrosis-factor-alpha-stimulated phospholipase A2 and prostaglandin E2 synthesis in rat renal mesangial cells. Dinoprostone 144-160 interleukin 1 beta Rattus norvegicus 59-111 2396988-3 1990 As shown previously, two proinflammatory cytokines, interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF alpha), are potent stimuli for PGE2 and phospholipase A2 secretion from mesangial cells. Dinoprostone 152-156 interleukin 1 beta Rattus norvegicus 52-70 2396988-3 1990 As shown previously, two proinflammatory cytokines, interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF alpha), are potent stimuli for PGE2 and phospholipase A2 secretion from mesangial cells. Dinoprostone 152-156 interleukin 1 beta Rattus norvegicus 72-81 2143636-4 1990 Central injection of antiserum significantly enhanced the thermogenic responses to interleukin 1 beta in rats treated with dexamethasone without affecting the responses in normal animals. Dexamethasone 123-136 interleukin 1 beta Rattus norvegicus 83-101 2396988-4 1990 We report here that, whereas TGF beta 2 potentiates the IL-1 beta- and TNF alpha-evoked PGE2 production, it strongly inhibits the phospholipase A2 secretion induced by both cytokines. Dinoprostone 88-92 interleukin 1 beta Rattus norvegicus 56-65 2115435-12 1990 The possible involvement of opiate-dependent pathways in mediating the inhibitory action of Il-1 beta on reproductive processes was tested by implanting naloxone pellets 16-24 h before lymphokine treatment. Naloxone 153-161 interleukin 1 beta Rattus norvegicus 92-101 2165999-10 1990 Taken together, these results indicate that IL-1 beta, essentially, and TNF-alpha, to a lesser extent, regulate 5"-nucleotidase expression in the plasma membrane of cultured mesangial cells and that their effect depends in part on PGE2 synthesis. Dinoprostone 231-235 interleukin 1 beta Rattus norvegicus 44-53 2166488-3 1990 The release of prostaglandin E2 and collagenase from adherent synovial cells stimulated with rIL-1 beta was also suppressed by rIFN gamma in all samples tested, though the basal release of these inflammatory mediators was little influenced. Dinoprostone 15-31 interleukin 1 beta Rattus norvegicus 93-103 2113380-5 1990 In addition, IL-1 beta but not TNF alpha treatment augmented the formation of PGE2 from exogenous arachidonic acid by mesangial cells. Dinoprostone 78-82 interleukin 1 beta Rattus norvegicus 13-22 2200107-0 1990 Interleukin 1 beta increases the cytosolic free sodium concentration in isolated rat islets of Langerhans. Sodium 48-54 interleukin 1 beta Rattus norvegicus 0-18 2111738-2 1990 Cyclophosphamide-treated mice received human rIL-1 beta at 7.0, 0.7, or 00.7 micrograms/kg, according to different regimens, to be challenged with a lethal ip inoculum of pseudomonas cells 5 days after myelosuppression. Cyclophosphamide 0-16 interleukin 1 beta Rattus norvegicus 45-55 2113380-2 1990 After pretreatment with interleukin 1 beta (IL-1 beta) or tumor necrosis factor alpha (TNF alpha), which are themselves potent stimuli for PGE2 synthesis, mesangial cells displayed an amplified response to angiotensin II and A23187. Dinoprostone 139-143 interleukin 1 beta Rattus norvegicus 24-42 2113380-2 1990 After pretreatment with interleukin 1 beta (IL-1 beta) or tumor necrosis factor alpha (TNF alpha), which are themselves potent stimuli for PGE2 synthesis, mesangial cells displayed an amplified response to angiotensin II and A23187. Dinoprostone 139-143 interleukin 1 beta Rattus norvegicus 44-53 2113380-4 1990 IL-1 beta and TNF alpha treatment also increased the amount of arachidonic acid released after stimulation of cells with angiotensin II and A23187. Arachidonic Acid 63-79 interleukin 1 beta Rattus norvegicus 0-9 2113380-4 1990 IL-1 beta and TNF alpha treatment also increased the amount of arachidonic acid released after stimulation of cells with angiotensin II and A23187. Calcimycin 140-146 interleukin 1 beta Rattus norvegicus 0-9 2113380-5 1990 In addition, IL-1 beta but not TNF alpha treatment augmented the formation of PGE2 from exogenous arachidonic acid by mesangial cells. Arachidonic Acid 98-114 interleukin 1 beta Rattus norvegicus 13-22 2113380-7 1990 These results suggest that IL-1 beta and TNF alpha exert a priming effect on PGE2 production in mesangial cells. Dinoprostone 77-81 interleukin 1 beta Rattus norvegicus 27-36 2201176-4 1990 "In vitro" stimulation of macrophage monolayers with IL-1 beta and the TNFs released a factor into the supernatant which, unlike these cytokines, induced neutrophil migration in dexamethasone pretreated animals. Dexamethasone 178-191 interleukin 1 beta Rattus norvegicus 53-62 2163723-8 1990 infusion of IL 1 beta produced a similar increase in plasma ACTH in rats whose catecholaminergic innervation to the hypothalamus had been obliterated by a bilateral injection of 6-hydroxydopamine into the ventral noradrenergic bundle, which appears to rule out modulation of this innervation in the stimulatory effect of IL 1 beta. Oxidopamine 178-195 interleukin 1 beta Rattus norvegicus 12-21 2164866-1 1990 Effects of recombinant interferon alpha (rhIFN alpha) and interleukin-1 beta (rhIL-1 beta) on the activity of glucose-responsive and glucose-unresponsive neurons in the ventromedial hypothalamus (VMH) were investigated with rat tissue slice preparations. Glucose 110-117 interleukin 1 beta Rattus norvegicus 58-76 2164866-1 1990 Effects of recombinant interferon alpha (rhIFN alpha) and interleukin-1 beta (rhIL-1 beta) on the activity of glucose-responsive and glucose-unresponsive neurons in the ventromedial hypothalamus (VMH) were investigated with rat tissue slice preparations. Glucose 133-140 interleukin 1 beta Rattus norvegicus 58-76 2190803-1 1990 Using a specific antiserum recognizing recombinant rat interleukin-1 beta (IL-1 beta), immunoreactive material was localized to cytoplasmic granules in anterior pituitary endocrine cells and colocalized with TSH in thyrotropes. Thyrotropin 208-211 interleukin 1 beta Rattus norvegicus 55-73 2190803-1 1990 Using a specific antiserum recognizing recombinant rat interleukin-1 beta (IL-1 beta), immunoreactive material was localized to cytoplasmic granules in anterior pituitary endocrine cells and colocalized with TSH in thyrotropes. Thyrotropin 208-211 interleukin 1 beta Rattus norvegicus 75-84 2103305-1 1990 Previous studies have demonstrated a stimulatory effect of interleukin-1 beta (IL-1 beta) on insulin and glucagon release from the perfused rat pancreas, accompanied by selective lysis of 20% of beta-cells as assessed by electronmicroscopy. Glucagon 105-113 interleukin 1 beta Rattus norvegicus 59-77 2157407-3 1990 Human rIL-1 beta caused a dose-dependent inhibition of hCG-, 8-bromo cyclic AMP-, and forskolin-induced testosterone formation. 8-Bromo Cyclic Adenosine Monophosphate 61-79 interleukin 1 beta Rattus norvegicus 6-16 2157407-3 1990 Human rIL-1 beta caused a dose-dependent inhibition of hCG-, 8-bromo cyclic AMP-, and forskolin-induced testosterone formation. Colforsin 86-95 interleukin 1 beta Rattus norvegicus 6-16 2157407-3 1990 Human rIL-1 beta caused a dose-dependent inhibition of hCG-, 8-bromo cyclic AMP-, and forskolin-induced testosterone formation. Testosterone 104-116 interleukin 1 beta Rattus norvegicus 6-16 2157407-5 1990 When the effects of the cytokines were corrected for their biological potencies, human rIL-1 beta and murine rIL-1 alpha were still more effective than human rIL-1 alpha in inhibiting testosterone production (at least 100-fold more potent). Testosterone 184-196 interleukin 1 beta Rattus norvegicus 87-97 2407518-0 1990 Interleukin-1-beta modulation of prolactin secretion from rat anterior pituitary cells: involvement of adenylate cyclase activity and calcium mobilization. Calcium 134-141 interleukin 1 beta Rattus norvegicus 0-18 2154976-5 1990 In the presence of both rTNF alpha and rIL-1 beta, hCG-induced cyclic AMP formation and binding of [125I]-hCG to Leydig cells were further inhibited. Cyclic AMP 63-73 interleukin 1 beta Rattus norvegicus 39-49 2103305-1 1990 Previous studies have demonstrated a stimulatory effect of interleukin-1 beta (IL-1 beta) on insulin and glucagon release from the perfused rat pancreas, accompanied by selective lysis of 20% of beta-cells as assessed by electronmicroscopy. Glucagon 105-113 interleukin 1 beta Rattus norvegicus 79-88 2103305-6 1990 In pancreata from animals pre-treated with IL-1 beta glucose-stimulated as well as IL-1 beta potentiated glucose-stimulated insulin release was almost completely abolished. Glucose 53-60 interleukin 1 beta Rattus norvegicus 43-52 2103305-9 1990 In contrast to the inhibitory effect of in vivo administration of IL-1 beta on beta-cell function glucagon secretion was stimulated. Glucagon 98-106 interleukin 1 beta Rattus norvegicus 66-75 2129785-1 1990 Recombinant Interleukin-1 beta (rIL-1 beta) induced dose-dependent synthesis of PGE2 and activation of both cell-associated and soluble phospholipase A2 (PLA2) in cultured mouse peritoneal macrophages. Dinoprostone 80-84 interleukin 1 beta Rattus norvegicus 32-42 2129785-4 1990 Stimulation with rIL-1 beta of macrophage cultures pre-labelled with [14C]arachidonic acid resulted in a loss of label from both phosphatidyl-choline and phosphatidylinositol in only 10 min, which was not observed in control (unstimulated) cultures. Carbon-14 70-73 interleukin 1 beta Rattus norvegicus 17-27 2129785-4 1990 Stimulation with rIL-1 beta of macrophage cultures pre-labelled with [14C]arachidonic acid resulted in a loss of label from both phosphatidyl-choline and phosphatidylinositol in only 10 min, which was not observed in control (unstimulated) cultures. Arachidonic Acid 74-90 interleukin 1 beta Rattus norvegicus 17-27 2129785-4 1990 Stimulation with rIL-1 beta of macrophage cultures pre-labelled with [14C]arachidonic acid resulted in a loss of label from both phosphatidyl-choline and phosphatidylinositol in only 10 min, which was not observed in control (unstimulated) cultures. Phosphatidylcholines 129-149 interleukin 1 beta Rattus norvegicus 17-27 2129785-4 1990 Stimulation with rIL-1 beta of macrophage cultures pre-labelled with [14C]arachidonic acid resulted in a loss of label from both phosphatidyl-choline and phosphatidylinositol in only 10 min, which was not observed in control (unstimulated) cultures. Phosphatidylinositols 154-174 interleukin 1 beta Rattus norvegicus 17-27 2266781-3 1990 The average release of dopamine (DA) decreased by 55% in the control group but 50 ng of IL-1 beta cut this decrease to 25%, and 100 ng of IL-1 beta not only completely prevented the decrease but raised the release by 44% (P less than 0.05). Dopamine 23-31 interleukin 1 beta Rattus norvegicus 88-97 2406177-4 1990 Interleukin-1 beta stimulated insulin secretion at 11 and 20 mmol/l D-glucose and potentiated first as well as second phase insulin release in a dose-dependent fashion, with decreasing effect at higher concentrations. Glucose 68-77 interleukin 1 beta Rattus norvegicus 0-18 2266781-4 1990 In a following 60-min period, when the hypothalami from the treatment groups were incubated without IL-1 beta, it resulted in sharp declines in the release of NE and DA, confirming that IL-1 beta was the stimulus for the increases in catecholamine release in the previous incubation period. Dopamine 166-168 interleukin 1 beta Rattus norvegicus 186-195 25220726-5 2014 RESULTS: gamma-PGA-Phe NPs produced a dose- and time-dependent inflammatory response characterized by generation of proinflammatory cytokines (IL-1alpha, IL-1beta, IL-6, MIP-1alpha, and TNF-alpha) and associated histopathological changes. poly(gamma-glutamic acid) 9-18 interleukin 1 beta Rattus norvegicus 154-162 2266781-4 1990 In a following 60-min period, when the hypothalami from the treatment groups were incubated without IL-1 beta, it resulted in sharp declines in the release of NE and DA, confirming that IL-1 beta was the stimulus for the increases in catecholamine release in the previous incubation period. Catecholamines 234-247 interleukin 1 beta Rattus norvegicus 186-195 2266781-5 1990 It is concluded that IL-1 beta stimulates the release of catecholamines (and probably other neurotransmitters) in the brain which, in turn, mediate its central and neuroendocrine actions. Catecholamines 57-71 interleukin 1 beta Rattus norvegicus 21-30 33939676-7 2021 The association of SPL with the VAG surgery attenuated, or abolished, the effects of VAG and reduced glucose-induced insulin secretion and interleukin-1beta area in beta cells, in addition to lowering vagal activity. vag 32-35 interleukin 1 beta Rattus norvegicus 139-156 29042248-8 2017 CSIS resulted in an increase in depressive- and anxiety-like behaviors that corresponded with compromised glutathione peroxidase (GPx)-mediated antioxidative defense and increased TNF-alpha, but not with changes in NF-kappaB, IL-1beta and COX-2 levels. csis 0-4 interleukin 1 beta Rattus norvegicus 226-234 25220726-5 2014 RESULTS: gamma-PGA-Phe NPs produced a dose- and time-dependent inflammatory response characterized by generation of proinflammatory cytokines (IL-1alpha, IL-1beta, IL-6, MIP-1alpha, and TNF-alpha) and associated histopathological changes. Phenylalanine 19-22 interleukin 1 beta Rattus norvegicus 154-162 23877802-6 2013 After 7 weeks of streptozotocin injection, the rats produced remarkable increase in escape latency, coupled with increased oxidative stress (increased MDA level and decreased SOD as well as reduced GSH), NF-kappaB p65 unit, TNF-alpha, IL-1beta, and caspase-3 in different regions of diabetic rat brain. Streptozocin 17-31 interleukin 1 beta Rattus norvegicus 235-243 24377193-9 2013 Moreover, the contents of IL-1beta, IL-18 and caspase-1 in the lung and BALF, downstream factors of inflammasome, were also dramatically lower in the Eda group than in the HILI group (P < 0.05 for all). Edaravone 150-153 interleukin 1 beta Rattus norvegicus 26-34 19722154-4 2009 In P28, under OF and FS exposure, IL-1beta-ir in the CeA remained unaltered but increased in the MeA and in the hippocampus after acute and chronic stress. phenylalanylserine 21-23 interleukin 1 beta Rattus norvegicus 34-42 19722154-6 2009 These data demonstrate that only the levels of IL-1beta-ir in juvenile rat brains are affected by FS and OF. phenylalanylserine 98-100 interleukin 1 beta Rattus norvegicus 47-55 34628574-8 2022 Despite the activation of macrophages by lipopolysaccharide, the mRNA expression of pro-inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta, was significantly suppressed in macrophages preliminarily treated with rMIKO-1 for 1 h. Complexes of rMIKO-1 with nuclear factor-kappa B (NF-kappaB)/p65 and beta-actin formed in activated macrophages, which attenuated experimental colitis in rats. rmiko- 258-264 interleukin 1 beta Rattus norvegicus 168-185 19115387-6 2009 Phenytoin attenuated by approximately 50% the release of IL-1 alpha, IL-1 beta, and TNF-alpha from LPS-stimulated microglia, but had minimal effects on the release of IL-2, IL-4, IL-6, IL-10, MCP-1, and TGF-alpha. Phenytoin 0-9 interleukin 1 beta Rattus norvegicus 69-78 19115387-7 2009 TTX (0.3 microM) reduced, but to a smaller extent, the release of IL-1 alpha, IL-1 beta, and TNF-alpha from activated microglia. Tetrodotoxin 0-3 interleukin 1 beta Rattus norvegicus 78-87 34562213-7 2022 In addition, MSG enhanced the hepatorenal inflammation as witnessed by increased inflammatory cytokines (interleukin-1b and tumor necrosis factor-alpha) and elevated nuclear factor-kappaB (NF-kappaB) levels. Sodium Glutamate 13-16 interleukin 1 beta Rattus norvegicus 105-119 34510370-10 2022 Additionally, the levels of the proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin 1beta and interleukin 6, detected by ELISA in the spinal cord of the rats with NP, were significantly inhibited by celastrol. celastrol 226-235 interleukin 1 beta Rattus norvegicus 99-116 34657267-7 2022 RESULTS: Opg and Il-1b expression levels were significantly associated with both diabetes and vitamin D3 supplementation in the aortas of the study groups (p <= 0.05). Cholecalciferol 94-104 interleukin 1 beta Rattus norvegicus 17-22 34510370-10 2022 Additionally, the levels of the proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin 1beta and interleukin 6, detected by ELISA in the spinal cord of the rats with NP, were significantly inhibited by celastrol. Neptunium 190-192 interleukin 1 beta Rattus norvegicus 99-116 34946578-4 2021 The flavonols could decrease the production of prostaglandin E2 and three pro-inflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha, and simultaneously promote the production of two anti-inflammatory cytokines IL-10 and transforming growth factor-beta. Flavonols 4-13 interleukin 1 beta Rattus norvegicus 101-118 34948340-12 2021 Differences revealed between MCAO-KM and MCAO-LM suggest that corticosterone and interleukin-1beta release as well as hippocampal accumulation is more expressed in MCAO-KM rats, predisposing them to corticosterone-dependent distant neuroinflammatory hippocampal damage. Corticosterone 199-213 interleukin 1 beta Rattus norvegicus 81-98 34740686-9 2021 Moreover, histopathological and biochemical alterations in brain contents of neurotransmitters, oxidative stress, and interleukin-1beta were induced by CR. Chromium 152-154 interleukin 1 beta Rattus norvegicus 118-135 34930229-11 2021 BBR considerably reduced BPH-stimulated oxidative stress and inflammation through preventing the rise in lipid peroxidation and nitrite concentration and declined the accumulations of pro-inflammatory cytokines (e.g. interleukin 1beta and tumor necrosis factor alpha) and declining the depletion rate of GSH and the function of catalase and superoxide dismutase. Berberine 0-3 interleukin 1 beta Rattus norvegicus 217-234 34975499-10 2021 the PPI network analysis demonstrated that the targets linked to MIRI were ALB, TNF, ACTB, AKT1, IL6, TP53, IL1B, CASP3 and these targets showed nice affinity with colchicine in molecular docking experiments. Colchicine 164-174 interleukin 1 beta Rattus norvegicus 108-112 34860003-7 2021 Furthermore, fustin significantly improved the altered levels of several biochemical parameters for cognitive dysfunction such as GSH, SOD, CAT, MDA, NO, and relative IL-6 and IL-1B compared to a diabetic control group. fustin 13-19 interleukin 1 beta Rattus norvegicus 176-181 34585992-5 2021 To authenticate the obtained outcomes, immunostaining for caspase-1, interleukin-1beta (IL-1beta), and phosphorylated tau (p-Tau) protein was conducted.Results: Behavioral experiments indicated that IND treatment was able to improve learning and memory performance (p<.05). Indomethacin 199-202 interleukin 1 beta Rattus norvegicus 69-86 34155936-6 2021 The anti-inflammatory effect of Carvacrol was confirmed by decreasing nuclear factor kappa B (NF-kappaB), interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) contents. carvacrol 32-41 interleukin 1 beta Rattus norvegicus 106-123 34399353-7 2021 PAH downregulated the expression of NLR family pyrin domain containing 3, cleaved/pro caspase-1, interleukin-1beta and interleukin-18 in spinal cord tissues of SCII rats. perillaldehyde 0-3 interleukin 1 beta Rattus norvegicus 97-114 34546477-3 2021 The present study aimed at evaluating the effects of combining MSC-conditioned medium with stigmasterol compared with the individual treatments in alleviating interleukin-1 beta (IL-1beta)-induced inflammation in rat chondrocytes. Stigmasterol 91-103 interleukin 1 beta Rattus norvegicus 159-177 34854012-11 2022 Besides, haloperidol caused significant increase in the proinflammatory cytokines (interleukin-1beta:IL-1beta, tumor necrosis factor-alpha: TNF-alpha and IL-6 and the co-treatment with isoflavones was able to reduce the levels of IL-1beta and TNF-alpha, but not IL-6. Haloperidol 9-20 interleukin 1 beta Rattus norvegicus 83-100 34959638-8 2021 However, carvedilol administration resulted in significant restoration of kidney glutathione (GSH) level and a decrease in kidney interleukin 1beta (IL-1beta) and plasma asymmetric dimethylarginine (ADMA) concentrations. Carvedilol 9-19 interleukin 1 beta Rattus norvegicus 130-147 34735841-5 2021 tDCS reverted the anxiety-like behavior induced by CCI and alcohol, and the increased expression of Il1a in the spinal cord induced by alcohol, which increased the expression of Il1b in the cerebellum. CCI 51-54 interleukin 1 beta Rattus norvegicus 178-182 34735841-5 2021 tDCS reverted the anxiety-like behavior induced by CCI and alcohol, and the increased expression of Il1a in the spinal cord induced by alcohol, which increased the expression of Il1b in the cerebellum. Alcohols 59-66 interleukin 1 beta Rattus norvegicus 178-182 34735841-5 2021 tDCS reverted the anxiety-like behavior induced by CCI and alcohol, and the increased expression of Il1a in the spinal cord induced by alcohol, which increased the expression of Il1b in the cerebellum. Alcohols 135-142 interleukin 1 beta Rattus norvegicus 178-182 34735841-7 2021 Thus, this study shows that tDCS changes NP and alcohol-induced anxiety-like behavior, possibly through its central modulatory effect of NPY and spinal cord expression of Il1a and Il1b, being considered a treatment option for alcohol and NP-induced anxiety symptoms. Alcohols 48-55 interleukin 1 beta Rattus norvegicus 180-184 34270001-9 2021 Ginsenoside Rg2 treatment ameliorated the ICH-induced augmentation of Evans blue extravasation, inhibited the ICH-induced elevation of brain water content, and reduced the interleukin-1beta and tumor necrosis factor-alpha levels in the hemorrhagic hemisphere after ICH in preeclampsia model rats. ginsenoside Rg2 0-15 interleukin 1 beta Rattus norvegicus 172-189 34817025-5 2021 RESULTS: Compared with VALI group, in VALI+propofol group the blood pH, partial pressure of oxygen, partial pressure of carbon dioxide and MAP were increased, the lung W/D, lung tissue myeloperoxidase activity and total protein concentration, white blood cell count, and tumor necrosis factor alpha, interleukin 1beta and interleukin 6 levels in BALF were decreased, and the p-p38 MAPK protein expression level and phosphorylated p38 MAPK (p-p38 MAPK)/p38 MAPK ratio were decreased. vali 38-42 interleukin 1 beta Rattus norvegicus 300-317 34817025-5 2021 RESULTS: Compared with VALI group, in VALI+propofol group the blood pH, partial pressure of oxygen, partial pressure of carbon dioxide and MAP were increased, the lung W/D, lung tissue myeloperoxidase activity and total protein concentration, white blood cell count, and tumor necrosis factor alpha, interleukin 1beta and interleukin 6 levels in BALF were decreased, and the p-p38 MAPK protein expression level and phosphorylated p38 MAPK (p-p38 MAPK)/p38 MAPK ratio were decreased. Propofol 43-51 interleukin 1 beta Rattus norvegicus 300-317 34817026-1 2021 PURPOSE: Reactive oxygen species (ROS), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) have been shown in the pathogenesis of acrylamide neurotoxicity. Acrylamide 152-162 interleukin 1 beta Rattus norvegicus 40-57 34789048-1 2021 We investigated how proanthocyanidin treatment altered c-Jun N-terminal kinases, transforming growth factor beta 1, serine/threonine-specific protein kinase, interleukin 1 beta and insulin-like 3 expression in the testis of diabetic rats. proanthocyanidin 20-36 interleukin 1 beta Rattus norvegicus 158-176 34836410-3 2021 The livers of ethanol-treated rats showed steatosis; necrosis and mononuclear infiltration; and significant upregulation of the mRNA expression of the prooxidant (Cyp2e1, iNos), lipogenic (Srebp1, Acc), proinflammatory (Tlr4, Nf-kappab, TnfA, Il-1B, and Il-6), and profibrogenic (TgfB, Col1, VegfA) genes. Ethanol 14-21 interleukin 1 beta Rattus norvegicus 243-248 34773542-4 2021 injection of SEW2871, a selective S1PR1 agonist, activates the nod-like receptor family, pyrin domain containing 3 inflammasome, increases interleukin-1beta (IL-1beta) and causes behavioral hypersensitivity. SEW2871 13-20 interleukin 1 beta Rattus norvegicus 139-156 34903409-11 2021 Severe burn-induced inflammation was suppressed by combined NaB and PROB administration, as demonstrated by the decreased mRNA expression of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, and high mobility group box-1 in the small intestine. nab 60-63 interleukin 1 beta Rattus norvegicus 185-202 34555642-7 2021 The protective effect of Gen on the injured spinal cord tissues was evaluated by measuring the water content, myeloperoxidase (MPO) activity, and levels of tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), and IL-6. geniposide 25-28 interleukin 1 beta Rattus norvegicus 197-214 34753902-6 2021 RESULTS: The inclusion of NAC increased the activity of mitochondrial complexes I and II + III as well as decreased the concentration of interleukin-1beta, tumor necrosis factor alpha, and caspase-3, but only in the parotid glands of rats with hyperglycemia compared to the HFD group. Acetylcysteine 26-29 interleukin 1 beta Rattus norvegicus 137-154 34314849-10 2021 RA treatment in a dose-dependent manner prevented the overproduction of tumor necrosis factor-alpha (TNF-alpha), interleukin 1 beta (IL-1beta), and IL-6 in both the HIP and PFC. rosmarinic acid 0-2 interleukin 1 beta Rattus norvegicus 113-131 34766659-5 2022 LUT increased glutathione and total sulphydryl levels and alleviated DOX-induced increases in the levels of reactive oxygen and nitrogen species, lipid peroxidation, myeloperoxidase, nitric oxide, tumor necrosis factor-alpha, and interleukin-1beta (IL-1beta). Doxorubicin 69-72 interleukin 1 beta Rattus norvegicus 230-247 34803702-7 2021 In addition, the active flavonoids not only alleviated MSU crystal-induced inflammation in synovial tissues by histopathological examination but also reduced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) levels in the joint tissue fluid of MSU crystal-induced rats. Flavonoids 24-34 interleukin 1 beta Rattus norvegicus 202-220 34803702-7 2021 In addition, the active flavonoids not only alleviated MSU crystal-induced inflammation in synovial tissues by histopathological examination but also reduced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) levels in the joint tissue fluid of MSU crystal-induced rats. Uric Acid 55-58 interleukin 1 beta Rattus norvegicus 202-220 34803702-7 2021 In addition, the active flavonoids not only alleviated MSU crystal-induced inflammation in synovial tissues by histopathological examination but also reduced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) levels in the joint tissue fluid of MSU crystal-induced rats. Uric Acid 268-271 interleukin 1 beta Rattus norvegicus 202-220 34507121-0 2021 L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta against isoproterenol-induced myocardial infarction. Carnitine 0-11 interleukin 1 beta Rattus norvegicus 141-158 34507121-0 2021 L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta against isoproterenol-induced myocardial infarction. Isoproterenol 167-180 interleukin 1 beta Rattus norvegicus 141-158 34517076-8 2021 Interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and inducible nitric oxide synthase (iNOS) expressions were upregulated in 2-CE-induced reactive astrocytes, enhancing IL-1beta, TNF-alpha, and nitric oxide (NO) excretions, which stimulated microglia polarization. Ethylene Chlorohydrin 146-150 interleukin 1 beta Rattus norvegicus 0-17 34478828-6 2021 Meanwhile, G15 or JB1 could attenuate the anti-inflammatory effects of genistein in LPS-induced microglial activation and production of tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Genistein 71-80 interleukin 1 beta Rattus norvegicus 177-194 34426999-0 2021 Icariin attenuates renal fibrosis in chronic kidney disease by inhibiting interleukin-1beta/transforming growth factor-beta-mediated activation of renal fibroblasts. icariin 0-7 interleukin 1 beta Rattus norvegicus 74-91 34363182-5 2021 DEX also attenuated LPS-induced inflammation and hippocampal apoptosis by inhibiting the increase of interleukin-1beta, interleukin-6, interleukin-18, and tumor necrosis factor-alpha levels and downregulating the expression of mitochondrial apoptosis pathway-related proteins. Dexmedetomidine 0-3 interleukin 1 beta Rattus norvegicus 101-118 34754366-10 2021 QR increased the reduction of the brain-derived neurotrophic factor that was elicited by RB-Ed and acts as an anti-inflammatory agent by reducing the proinflammatory marker, interleukin 1 beta and DNA damage markers, heat shock protein 70, and 8-hydroxydeoxyguanosine. rb-ed 89-94 interleukin 1 beta Rattus norvegicus 174-192 34691354-8 2021 Low-dose alcohol also attenuated AS-induced oxidative stress and inflammation, presenting as reduced malondialdehyde and hydrogen peroxide formation, increased superoxide dismutase and glutathione activity, and decreased myeloperoxidase, interleukin-6, interleukin-1beta, and monocyte chemoattractant protein-1 levels (P < 0.05). Alcohols 9-16 interleukin 1 beta Rattus norvegicus 253-270 34681847-4 2021 In the cell model, linagliptin attenuated ROS by activating the AMP-activated protein kinase (AMPK) pathway, restoring nuclear-factor-erythroid-2-related factor (Nrf2) and heme oxygenase 1 (HO-1) protein, and decreasing pro-inflammatory cytokines (tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1beta)). Linagliptin 19-30 interleukin 1 beta Rattus norvegicus 292-310 34650664-7 2021 Our observations indicated that DL0410 reduced the production of harmful oxidation products and promoted the antioxidative system, decreased the levels of proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), and interleukin 6 (IL-6), and increased anti-inflammatory cytokines IL-10. DL0410 32-38 interleukin 1 beta Rattus norvegicus 233-250 34679060-7 2021 In vehicle-treated rats, the immunoreactivities of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1-beta (IL-1beta), as pro-inflammatory cytokines, were increased, and the immunoreactivities of IL-4 and IL-13, as anti-inflammatory cytokines, were reduced with time after ACA/CPR. 4-amylcinnamoylanthranilic acid 280-283 interleukin 1 beta Rattus norvegicus 95-113 34712949-5 2021 Mesalamine and the HT diminished the length of the lesions formed in the colon, in addition to reducing the levels of myeloperoxidase and interleukin-1beta. Mesalamine 0-10 interleukin 1 beta Rattus norvegicus 138-155 34600570-9 2021 Our outcomes of TNF-a, IL-1B, and MDA evaluation show a significant ameliorating effect of the Berberine (BBR) and BBR-loaded micelles in pretreated groups. Berberine 115-118 interleukin 1 beta Rattus norvegicus 23-28 34217992-12 2021 In addition, betulin reduced hepatic inflammation via significant inhibition of NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome, caspase-1 and interleukin-1beta (IL-1beta) levels. betulin 13-20 interleukin 1 beta Rattus norvegicus 168-185 34332740-7 2021 In lipopolysaccharide-stimulated peritoneal immune cells, MitoTEMPO abrogated the increase in mROS (P=0.006) and interleukin-1beta (IL-1beta) (P=0.03) without affecting non-mitochondrial oxygen consumption or the phagocytotic-induced respiratory burst (P>0.05). MitoTEMPO 58-67 interleukin 1 beta Rattus norvegicus 113-130 34242901-5 2021 Testosterone promoted the expression of interleukin 1-beta (IL-1beta), interleukin 6 (IL-6), Inducible nitric oxide synthase (iNOS), and tumor necrosis factor alpha (TNF-alpha); the MIF antibody could reverse this effect. Testosterone 0-12 interleukin 1 beta Rattus norvegicus 40-58 34661261-8 2021 MTX administration also resulted in downregulation of vascular endothelial growth factor (VEGF), while caused upregulation of interleukin 1 beta (IL-1B) and interleukin 6 (IL-6) in comparison to the control group. Methotrexate 0-3 interleukin 1 beta Rattus norvegicus 126-144 34661261-8 2021 MTX administration also resulted in downregulation of vascular endothelial growth factor (VEGF), while caused upregulation of interleukin 1 beta (IL-1B) and interleukin 6 (IL-6) in comparison to the control group. Methotrexate 0-3 interleukin 1 beta Rattus norvegicus 146-151 34284077-10 2021 Quantitative Reverse transcription-polymerase chain reaction (qRT-PCR) results also showed that PIP reduced the expression of pro-inflammatory protein, interleukin-1 beta (IL-1beta) and enhanced cell survival by restoring the activity of brain derived neurotrophic factor (BDNF) and its transcription protein, cAMP response element binding protein (CREB). piperine 96-99 interleukin 1 beta Rattus norvegicus 152-170 34339751-8 2021 Moreover, chrysin formulations were able to inhibit doxorubicin-induced Tol-like receptor 4 (TLR4) and p65 subunit of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) protein expression which in turn, reduced procaspase-1, Cysteinyl Aspartate Protease-1 (caspase-1) and Interleukin-1beta (IL-1beta) protein expression via inhibiting Nod-like receptor pyrin containing 3 (NLRP3) inflammasome. Doxorubicin 52-63 interleukin 1 beta Rattus norvegicus 292-309 34252404-0 2021 Alcohol drinking during early adolescence activates microglial cells and increases frontolimbic Interleukin-1 beta and Toll-like receptor 4 gene expression, with heightened sensitivity in male rats compared to females. Alcohols 0-7 interleukin 1 beta Rattus norvegicus 96-114 34252404-8 2021 Il1b mRNA changes were not observed in the hippocampus, but alcohol elevated Tlr4 mRNA in both sexes, highlighting regional specificity in inflammatory responses to alcohol. Alcohols 165-172 interleukin 1 beta Rattus norvegicus 0-4 34339751-8 2021 Moreover, chrysin formulations were able to inhibit doxorubicin-induced Tol-like receptor 4 (TLR4) and p65 subunit of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) protein expression which in turn, reduced procaspase-1, Cysteinyl Aspartate Protease-1 (caspase-1) and Interleukin-1beta (IL-1beta) protein expression via inhibiting Nod-like receptor pyrin containing 3 (NLRP3) inflammasome. chrysin 10-17 interleukin 1 beta Rattus norvegicus 292-309 34197778-8 2021 Moreover, PCA significantly decreased L-arginine induced elevation in pancreatic high motility group box protein 1 (HMGB1), toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), nuclear factor kappa B (NF-kappaB), tumor necrosis factor- alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) expression. Arginine 38-48 interleukin 1 beta Rattus norvegicus 274-291 34684325-11 2021 Finally, EM markedly reduces renal inflammation and serum interleukin-1beta levels. em 9-11 interleukin 1 beta Rattus norvegicus 58-75 34382399-7 2021 We found that OMG could suppress TNF-alpha-induced expression of pro-inflammatory cytokines (interleukin-1beta (IL-1beta), IL-6, and IL-8) and inhibit oxidative stress by reducing the production of H2O2 and protein carbonyl. 2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)-2,6-dihydropyrrolo(3,4-c)pyrazol-5(4H)-yl)tetrahydro-2H-pyran-3-amine 14-17 interleukin 1 beta Rattus norvegicus 93-110 34542833-14 2021 Treatment with sinigrin suppressed the Il1b and Nlrp3 gene expression at hippocampal level. sinigrin 15-23 interleukin 1 beta Rattus norvegicus 39-43 34572376-8 2021 Tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 concentrations, but not IL-10 levels, also increased in the ipsilateral spinal cord after CCI. CCI 170-173 interleukin 1 beta Rattus norvegicus 41-58 34459233-12 2021 Doxorubicin decreased antioxidative enzymes (superoxide dismutase and glutathione peroxidase) and increased myocardial injury biomarkers (creatine kinase isoenzyme MB, cardiac troponin I, and brain natriuretic peptide), proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6), malondialdehyde, and myocardial fibers. Doxorubicin 0-11 interleukin 1 beta Rattus norvegicus 276-293 34903915-13 2021 Bubaline fibrin glue application led to a significant reduction of Tnfa and Il1b mRNA levels, while an increased expression of Pdgfa, Tgfb1, and Il10 was observed compared with the control. bubaline 0-8 interleukin 1 beta Rattus norvegicus 76-80 34483144-7 2021 The anti-inflammatory effect of betaine was confirmed by the downregulation of pro-inflammation-related molecules, including vascular cell adhesion molecule 1 and interleukin-1beta in the retinas of rats with EAU. Betaine 32-39 interleukin 1 beta Rattus norvegicus 163-180 34130351-9 2021 Serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) were significantly decreased after USW therapy. USW 124-127 interleukin 1 beta Rattus norvegicus 60-77 34182247-15 2021 The cytokines, including interferon-gamma, tumor necrosis factor-alpha, and interleukin 1beta, 6, 10, and 13, were significantly upregulated in the spleen of rats exposed to TBZ, MSG, and BB. Thiabendazole 174-177 interleukin 1 beta Rattus norvegicus 76-93 34182247-15 2021 The cytokines, including interferon-gamma, tumor necrosis factor-alpha, and interleukin 1beta, 6, 10, and 13, were significantly upregulated in the spleen of rats exposed to TBZ, MSG, and BB. Sodium Glutamate 179-182 interleukin 1 beta Rattus norvegicus 76-93 34182247-15 2021 The cytokines, including interferon-gamma, tumor necrosis factor-alpha, and interleukin 1beta, 6, 10, and 13, were significantly upregulated in the spleen of rats exposed to TBZ, MSG, and BB. brilliant blue 188-190 interleukin 1 beta Rattus norvegicus 76-93 34448458-4 2021 The results showed a favorable increase in the hemoglobin level, antioxidant enzymes (SOD and CAT), restored electrochemical balance (carbon dioxide & anion gap) while a noticeable decrease in ulcer index, total acidity, lipid peroxides, inflammatory cytokines (interleukin-1 beta (IL-1beta), IL-6, and tumor necrosis factor alpha) in rats treated with the cirsilineol. cirsilineol 357-368 interleukin 1 beta Rattus norvegicus 262-280 34236500-4 2021 Our results displayed that ZnO NPs attenuated adjuvant-induced increased production of inflammatory mediators interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), interleukin-10 (IL-10), and total leukocyte count. Zinc Oxide 27-30 interleukin 1 beta Rattus norvegicus 110-127 34483144-7 2021 The anti-inflammatory effect of betaine was confirmed by the downregulation of pro-inflammation-related molecules, including vascular cell adhesion molecule 1 and interleukin-1beta in the retinas of rats with EAU. Water 209-212 interleukin 1 beta Rattus norvegicus 163-180 34468508-10 2021 The results demonstrated that thimerosal significantly increased the inflammation indicators including nuclear factor kappaB (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha), Interleukin-1beta (IL-1beta), Interleukin-6 (IL-6) levels and cyclooxygenase-2 (COX-2) activities, DNA and histopathological damages dose-dependently. Thimerosal 30-40 interleukin 1 beta Rattus norvegicus 179-196 34434111-5 2021 Metformin significantly reduced silica particle-induced inflammatory cytokines including transforming growth factor-beta1 (TGF-beta1), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in rat lung tissue and HBEC culture supernatant. Metformin 0-9 interleukin 1 beta Rattus norvegicus 179-196 34396994-7 2022 Results showed that only interleukin-1beta(IL-1beta) had significantly increased mRNA-expression in the prostate of EAP rats compared to the controls (P < 0.001) and significantly higher protein concentrations in both the serum (P = 0.001) and CSF (P < 0.001) of the EAP groups compared to the Control groups. phosphorylethanolamine 116-119 interleukin 1 beta Rattus norvegicus 25-42 34396994-7 2022 Results showed that only interleukin-1beta(IL-1beta) had significantly increased mRNA-expression in the prostate of EAP rats compared to the controls (P < 0.001) and significantly higher protein concentrations in both the serum (P = 0.001) and CSF (P < 0.001) of the EAP groups compared to the Control groups. phosphorylethanolamine 267-270 interleukin 1 beta Rattus norvegicus 25-42 34434111-5 2021 Metformin significantly reduced silica particle-induced inflammatory cytokines including transforming growth factor-beta1 (TGF-beta1), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in rat lung tissue and HBEC culture supernatant. Silicon Dioxide 32-38 interleukin 1 beta Rattus norvegicus 179-196 34114917-3 2021 Plasmid transfection was performed to explore the role of miR-210 in the effect of paeoniflorin.Results: Firstly, we confirmed that hypoxia induced severe neuronal injury and an enhancement of inflammation in the rat brain, with elevated expression of caspase1, IL1b and IL18. peoniflorin 83-95 interleukin 1 beta Rattus norvegicus 262-266 34439442-6 2021 The administration of CsA also significantly downregulated the renal expression of interferon-gamma, tumor necrosis factor-alpha, interleukin 1 beta, monocyte chemotactic protein 1, intercellular adhesion molecule-1, and vascular cell adhesion molecule 1 genes, and increased renal DNA damage. Cyclosporine 22-25 interleukin 1 beta Rattus norvegicus 130-148 33433498-7 2021 However, DA-CH5 showed curative effects in reducing the levels of alpha-synuclein and the levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta). da-ch5 9-15 interleukin 1 beta Rattus norvegicus 157-174 34221806-5 2021 Rapamycin treatment alleviated I/R-induced lung histopathologically injury and increased the concentration of MDA while decreased activity of SOD and expression of NLRP3, Caspase-1, interleukin-1beta (IL-1beta), and IL-18 in rat. Sirolimus 0-9 interleukin 1 beta Rattus norvegicus 182-199 34381778-12 2021 Two weeks later, emodin prevented the depression behaviors in DeS rats along with a series of pathological changes in their hippocampi, such as loss of neurons and spines, microglial activation, increased interleukin-1beta and tumor necrosis factor-alpha, and the activation of 5-LO. Emodin 17-23 interleukin 1 beta Rattus norvegicus 205-222 34294819-8 2021 Furthermore, upregulated expressions of Interleukin-1beta, Interleukin-6, and NF-kB-p65 in the PA control were attenuated, while decreased Interleukine-10 expression was upregulated due to lycopene treatment. Palmitic Acid 95-97 interleukin 1 beta Rattus norvegicus 40-57 34294819-8 2021 Furthermore, upregulated expressions of Interleukin-1beta, Interleukin-6, and NF-kB-p65 in the PA control were attenuated, while decreased Interleukine-10 expression was upregulated due to lycopene treatment. Lycopene 189-197 interleukin 1 beta Rattus norvegicus 40-57 34284820-7 2021 CONCLUSION: Berberine has a protective effect on NSAID-associated small intestinal injury, the mechanism may be that berberine decreases the expression of intestinal mucosa HTR4, F2RL3, NPY, CRHR2, IL1b, VIP, AQP8, and increases the expression of NOS1, that to reduce intestinal permeability and protect intestinal mucosal barrier. Berberine 12-21 interleukin 1 beta Rattus norvegicus 198-202 34284820-7 2021 CONCLUSION: Berberine has a protective effect on NSAID-associated small intestinal injury, the mechanism may be that berberine decreases the expression of intestinal mucosa HTR4, F2RL3, NPY, CRHR2, IL1b, VIP, AQP8, and increases the expression of NOS1, that to reduce intestinal permeability and protect intestinal mucosal barrier. Berberine 117-126 interleukin 1 beta Rattus norvegicus 198-202 34191510-4 2021 Sodium sulfite increased the generation of ROS and the expression of NLRP3, caspase-1, gasdermin D N-terminal (GSDMD-N), interleukin-1beta (IL-1beta), and interleukin-18 (IL-18). sodium sulfite 0-14 interleukin 1 beta Rattus norvegicus 121-138 34141152-6 2021 Moreover, taurine effectively mitigated increase in myeloperoxidase activity, levels of reactive oxygen and nitrogen species, nitric oxide and interleukin-1beta in kidney and liver of rats treated with B(a)P. Taurine 10-17 interleukin 1 beta Rattus norvegicus 143-160 34243628-6 2021 In the acrylamide group, malondialdehyde (MDA), tumour necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1beta) levels were found to be high, total glutathione (tGSH) levels were found to be low, and there was severe interstitial haemorrhage; additionally, tubular necrosis, tubular atrophy, leucocyte infiltration, and glomerular structures with expanded Bowman"s space were observed. Acrylamide 7-17 interleukin 1 beta Rattus norvegicus 94-112 34306253-6 2021 Strikingly, in HF rats induced by isoproterenol (ISO), the expression of miR-181b of heart tissue was suppressed before tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) increase, as revealed by western blot and real-time PCR. Isoproterenol 34-47 interleukin 1 beta Rattus norvegicus 161-178 34306253-6 2021 Strikingly, in HF rats induced by isoproterenol (ISO), the expression of miR-181b of heart tissue was suppressed before tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) increase, as revealed by western blot and real-time PCR. Isoproterenol 49-52 interleukin 1 beta Rattus norvegicus 161-178 33318415-5 2021 Quercetin markedly increased the thickness of the retinal cell layer, increased the number of ganglion cells, and decreased the overexpression of the pro-inflammatory factors interleukin-1beta, interleukin-18, interleukin-6 and tumor necrosis factor-alpha in the retinal tissue as well as the overexpression of high mobility group box-1 and the overactivation of the NLRP3 inflammasome. Quercetin 0-9 interleukin 1 beta Rattus norvegicus 175-192 34257810-6 2021 The testicular concentration of interleukin 10 was increased while interleukin 1 beta, interleukin 6, tumor necrosis factor alpha, and nuclear factor kappa B were decreased after consumption of omega-3 or omega-6. omega-3 194-201 interleukin 1 beta Rattus norvegicus 67-85 34257810-6 2021 The testicular concentration of interleukin 10 was increased while interleukin 1 beta, interleukin 6, tumor necrosis factor alpha, and nuclear factor kappa B were decreased after consumption of omega-3 or omega-6. omega-6 205-212 interleukin 1 beta Rattus norvegicus 67-85 34146399-10 2021 Furthermore, ginsenoside Rc could attenuate myocardial histological changes and structural abnormalities, decrease apoptotic cells and reduce the mRNA levels and activity of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 (p < 0.01). Ginsenosides 13-24 interleukin 1 beta Rattus norvegicus 215-232 34194520-14 2021 D-galactose also decreased the levels of acetylcholinesterase and acetylcholine and increased the level of glial fibrillary acidic protein, ionized calcium-binding adapter molecule 1, tumor necrosis factor-alpha (TNF-alpha), interleukin 1 beta (IL-1beta), interleukin 6 (IL-6), and interferon-gamma (IFN-gamma). Galactose 0-11 interleukin 1 beta Rattus norvegicus 225-243 34917292-7 2021 Multiple parameters, such as lipid peroxidation, the oxidized form of glutathione, interleukin 1 beta, tumor necrosis factor-alpha, and Bax were increased by METH therapy, while the reduced type of glutathione, Bcl-2, P-CREB, and BDNF concentrations in the hippocampus were decreased. Methamphetamine 158-162 interleukin 1 beta Rattus norvegicus 83-101 34141152-6 2021 Moreover, taurine effectively mitigated increase in myeloperoxidase activity, levels of reactive oxygen and nitrogen species, nitric oxide and interleukin-1beta in kidney and liver of rats treated with B(a)P. Phosphorus 206-207 interleukin 1 beta Rattus norvegicus 143-160 34782578-2 2022 In this study, we found that intraperitoneal administration of lithium chloride (LiCl) in a rat model of spinal cord injury alleviated pathological spinal cord injury and inhibited expression of tumor necrosis factor alpha, interleukin-6, and interleukin 1 beta. Lithium Chloride 63-79 interleukin 1 beta Rattus norvegicus 243-261 34628795-11 2021 In addition, IL-1b and IL-6 levels were significantly increased in the serum of ICH rats and in the supernatant of hemin-induced PC12 cells (p < 0.01). Hemin 115-120 interleukin 1 beta Rattus norvegicus 13-18 35429606-3 2022 Studies suggest that the cytokine interleukin-1beta (IL-1beta) depends upon cyclooxygenase (COX)-mediated prostaglandin E2 production for the induction of neural mechanisms to elicit fever. Dinoprostone 106-122 interleukin 1 beta Rattus norvegicus 34-51 35472453-11 2022 Moreover, inosine boosted the striatal brain-derived neurotrophic factor (BDNF) level, p-tropomyosin receptor kinase B (TrKB), p-ERK, and p-cAMP response element-binding protein (CREB) expression, which subsequently suppressed oxidative stress biomarkers (malondialdehyde and nitric oxide) and pro-inflammatory cytokines (tumor necrosis factor alpha and interleukin-1beta) and replenished the glutathione content. Inosine 10-17 interleukin 1 beta Rattus norvegicus 354-371 35578028-8 2022 RESULTS: Compared to controls, the high Cho diet produced a robust increase in NASH like phenotype that included increased expression of hepatic (Tnfa, Il1b, and Mcp1) and circulatory (TNFalpha and IL-1beta) markers of inflammation, steatosis, necrosis, fibrosis, and mononuclear cell infiltration. Cholesterol 40-43 interleukin 1 beta Rattus norvegicus 152-156 34782578-2 2022 In this study, we found that intraperitoneal administration of lithium chloride (LiCl) in a rat model of spinal cord injury alleviated pathological spinal cord injury and inhibited expression of tumor necrosis factor alpha, interleukin-6, and interleukin 1 beta. Lithium Chloride 81-85 interleukin 1 beta Rattus norvegicus 243-261 35600969-3 2023 The hydrogel could effectively encapsulate BMSCs, and played a remarkable neuroprotective role in vivo by reducing the production of endogenous ROS, attenuating ROS-mediated oxidative damage and downregulating the inflammatory cytokines such as interleukin-1 beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), resulting in a reduced cell apoptosis in the spinal cord tissue. Reactive Oxygen Species 144-147 interleukin 1 beta Rattus norvegicus 245-263 35446003-13 2022 Minocycline treatment inhibited MPH-induced mood disorders and decreased lipid peroxidation, oxidized form of glutathione (GSSG), interleukin 1 beta (IL-1beta), alpha tumor necrosis factor (TNF-alpha), Bax, and GSK3 levels. Minocycline 0-11 interleukin 1 beta Rattus norvegicus 130-148 35567927-4 2022 Sipeimine alleviated lung injury caused by PM2.5 and decreased pulmonary edema, inflammation and the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in the bronchoalveolar lavage fluid. peiminine 0-9 interleukin 1 beta Rattus norvegicus 155-172 35546555-3 2022 Here, we show that mucosal barrier injury induced by the mucotoxic chemotherapeutic agent, high-dose melphalan (HDM), is characterized by hyper-active IL-1b/CXCL1/neutrophil signaling. Melphalan 101-110 interleukin 1 beta Rattus norvegicus 151-156 35551403-7 2022 Interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and the number of infiltrating inflammatory cells were reduced in cardiac tissues of OLE-treated groups compared with the diabetic rats (effect size; etap2 = 0.969 and 0.949, respectively). Oleic Acid 156-159 interleukin 1 beta Rattus norvegicus 0-17 35413880-9 2022 Moreover, dapagliflozin attenuated nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome activation in lung tissues and the levels of interleukin-1beta (IL-1beta) and interleukin-18 (IL-18) in plasma. dapagliflozin 10-23 interleukin 1 beta Rattus norvegicus 151-168 35484458-9 2022 Moreover, apigenin administration suppressed renal inflammation and apoptosis by decreasing levels of interleukin-1beta, tumor necrosis factor-alpha, nuclear factor kappa-B, Bax, and caspase-3, while increasing B-cell lymphoma-2 compared with those in GM-administered group. Apigenin 10-18 interleukin 1 beta Rattus norvegicus 102-119 35586044-11 2022 It also reduced the expression and release of the inflammatory cytokine interleukin-1beta by promoting CGI-58 expression and inhibiting the expression of FFA, TNF-alpha, and the NLRP3 inflammasome induced by ROS. Reactive Oxygen Species 208-211 interleukin 1 beta Rattus norvegicus 72-89 35413380-7 2022 Hesperidin also showed anti-inflammatory and anti-autophagic effects by decreasing levels of NF-kappaB, IL-1B, TNF-alpha, Beclin-1, LC3A, and LC3B in NaF-induced brain tissue. Hesperidin 0-10 interleukin 1 beta Rattus norvegicus 104-109 35488217-8 2022 RESULTS: DEX significantly decreased apoptosis rates and inhibited interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) release (P < 0.05). Dexmedetomidine 9-12 interleukin 1 beta Rattus norvegicus 67-85 35417044-9 2022 Besides, shikonin reduced KTECs apoptosis, malondialdehyde (MDA), reactive oxygen species (ROS), interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) levels, while augmented SOD and IL-10 levels. shikonin 9-17 interleukin 1 beta Rattus norvegicus 97-114 35456948-7 2022 Neferine pretreatment also decreased glial cell activation and proinflammatory cytokine (interleukin-1beta, interleukin-6, tumor necrosis factor-alpha) expression in the hippocampi of rats with KA. neferine 0-8 interleukin 1 beta Rattus norvegicus 89-106 35156781-16 2022 RESULTS: Thiamine pyrophosphate significantly decreased the cyclophosphamide-induced increase in the levels of the oxidant parameter malondialdehyde (MDA), proinflammatory nuclear factor kappa B (NF-kappaB), tumor necrosis factor alpha (TNF-alpha), and interleukin 1 beta (IL-1beta). Thiamine Pyrophosphate 9-31 interleukin 1 beta Rattus norvegicus 253-271 34988900-4 2022 Riluzole applied in a single dose immediately post-SCI decreased the mRNA level of interleukin-1beta at 6 h, reduced the destruction of neurons, and reduced the activation of microglia/macrophage M1 expression at day 1 post-SCI. Riluzole 0-8 interleukin 1 beta Rattus norvegicus 83-100 35408518-7 2022 In addition, DXB markedly upregulated cardiorenal malondialdehyde, tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 levels and decreased glutathione, superoxide dismutase and catalase activities. Doxorubicin 13-16 interleukin 1 beta Rattus norvegicus 96-113 35614889-8 2022 Also, DMBA significantly increased inflammatory and oxidative stress markers serum interleukin-1beta (IL-1beta), lipid peroxidation (LPO) and myeloperoxidase (MPO) by 27, 18 and 435%, respectively. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 6-10 interleukin 1 beta Rattus norvegicus 83-100 35281931-5 2022 The in vitro experiments demonstrated that bilobalide significantly inhibited the production of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and matrix metalloproteinase 13 (MMP13) in ATDC5 chondrocytes induced by Interleukin-1beta (IL-1beta). bilobalide 43-53 interleukin 1 beta Rattus norvegicus 235-252 35193490-7 2022 Therefore, quercetin exhibits anti-inflammatory effect in a rat RA model as evidenced by reducing the specific activity of ADA in joint tissues, lower jaw volume, enhance body weight, downregulate ADA gene expression, reduce levels of RA cytokines interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, also, rheumatoid factor, C-reactive protein, and anti-cyclic citrullinated peptide RA biomarker levels. Quercetin 11-20 interleukin 1 beta Rattus norvegicus 248-265 35384154-6 2022 Galangin reduced cadmium-evoked inflammatory response and oxidative stress as indicated by reduced levels of interleukin-1 beta and TNF-alpha, decreased DNA damage, and improved antioxidant potential of the renal tissues. galangin 0-8 interleukin 1 beta Rattus norvegicus 109-127 35043648-8 2022 Second, the effects of mangiferin on the expression levels of matrix metalloproteinase (MMP)-13, TNF-alpha, Collagen II, Caspase-3, and cystatin-C in interleukin-1beta (IL-1beta)-induced rat chondrocytes were examined by the real-time polymerase chain reaction in vitro, meanwhile the effects of mangiferin on the nuclear factor kappa-B (NF-kappaB) signaling pathway were also investigated by Western Blot. mangiferin 23-33 interleukin 1 beta Rattus norvegicus 150-167 35387355-9 2022 qRT-PCR showed that CGS 21680 significantly increased the expression of interleukin-1beta. 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine 20-29 interleukin 1 beta Rattus norvegicus 72-89 35018576-7 2022 A significant reduction in pro-inflammatory markers, Il2, II6, and Il1b, was observed in the hippocampus, somatosensory cortex, and prefrontal cortex following lithium treatment. Lithium 160-167 interleukin 1 beta Rattus norvegicus 67-71 35184279-0 2022 Diacerein-induced interleukin-1beta deficiency reduces the inflammatory infiltrate and immunoexpression of matrix metalloproteinase-8 in periodontitis in rat molars. diacerein 0-9 interleukin 1 beta Rattus norvegicus 18-35 35156781-16 2022 RESULTS: Thiamine pyrophosphate significantly decreased the cyclophosphamide-induced increase in the levels of the oxidant parameter malondialdehyde (MDA), proinflammatory nuclear factor kappa B (NF-kappaB), tumor necrosis factor alpha (TNF-alpha), and interleukin 1 beta (IL-1beta). Cyclophosphamide 60-76 interleukin 1 beta Rattus norvegicus 253-271 34984694-7 2022 AFL treatment also elevated serum glutathione peroxidase and superoxide dismutase levels, while reducing serum interleukin-6, tumor necrosis factor-alpha, and interleukin-1beta levels. aflatoxicol 0-3 interleukin 1 beta Rattus norvegicus 159-176 34954769-6 2022 In addition, ginsenoside Rg1also significantly inhibits the activities of the inflammatory factors tumor necrosis factor-alpha, interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) to reduce the inflammatory response after trauma. ginsenoside rg1also 13-32 interleukin 1 beta Rattus norvegicus 128-145 35126806-10 2022 Empagliflozin decreased the increased levels of malondialdehyde, interleukin 1beta, and tumor necrosis factor alpha. empagliflozin 0-13 interleukin 1 beta Rattus norvegicus 65-82 35059981-8 2022 Additionally, RSV-SeNPs downregulate signal transducer and activator of transcription (STAT3) expression as well as interleukin-1beta (IL-1beta) levels, therefore alleviating neuroinflammation in AD. Resveratrol 14-17 interleukin 1 beta Rattus norvegicus 116-133 35057576-5 2022 It was also observed that HI increased the levels of interleukin-1beta in the hippocampus, and that PTE-treatment prevented this effect. hi 26-28 interleukin 1 beta Rattus norvegicus 53-70 35057576-5 2022 It was also observed that HI increased the levels of interleukin-1beta in the hippocampus, and that PTE-treatment prevented this effect. pte 100-103 interleukin 1 beta Rattus norvegicus 53-70 35237420-8 2022 We also analyzed interleukin 1beta expression using lung homogenates, and significant increase in interleukin 1beta was observed in 3-day silica-exposed rats. Silicon Dioxide 138-144 interleukin 1 beta Rattus norvegicus 98-115 35110503-10 2022 In primary cultured rat hepatocytes treated with interleukin-1beta, all these decarboxylated amino acids suppressed the production of nitric oxide, a proinflammatory mediator. Nitric Oxide 134-146 interleukin 1 beta Rattus norvegicus 49-66 34980778-10 2022 Curcumin + HH inhibited the expression and production of interleukin 1beta (IL-1beta), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and p65 nuclear factor kappa B (NF-kappaB) in the DRG. Curcumin 0-8 interleukin 1 beta Rattus norvegicus 57-74 35048998-7 2022 Furthermore, quantitative polymerase chain reaction (qPCR) was performed to determine the messenger ribonucleic acid (mRNA) expressions of interleukin-1 beta (IL-1beta) and IL-6, the content of IL-1beta and IL-6 was detected by enzyme-linked immunosorbent assay (ELISA), and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay was conducted to examine the cell apoptosis. deoxyuridine triphosphate 322-326 interleukin 1 beta Rattus norvegicus 139-157 35113429-4 2022 This study aimed to evaluate leukocyte counts, interleukin-1 beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) cytokine values and organ inflammatory processes in hydroxyurea-treated rats with an experimental sepsis model. Hydroxyurea 180-191 interleukin 1 beta Rattus norvegicus 47-65 34238176-11 2022 In addition, Etoricoxib significantly down-regulated the protein expression of interleukin 1 beta (IL-1beta), tumor necrosis factor alpha (TNFalpha), nuclear Factor-kappa B (NF-kappaB), phosphorylated nuclear Factor-kappa B (p-NF-kappaB), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2). Etoricoxib 13-23 interleukin 1 beta Rattus norvegicus 79-97 35366176-10 2022 Moreover, DIA dose-dependently alleviated oxidative stress status caused by APAP administration along with inflammatory markers, including the level of interleukin-1 beta (IL-1beta), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-alpha), and interleukin 6 (IL-6). diacerein 10-13 interleukin 1 beta Rattus norvegicus 152-170 35370216-11 2022 Daphnetin treatment significantly altered the level of phase I and phase II enzymes and also significantly (p < 0.001) decreased the level of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha); inflammatory mediators include cyclooxygenase-2 (COX-2), nuclear kappa B factor (NF-kappaB) and prostaglandin (PGE2). daphnetin 0-9 interleukin 1 beta Rattus norvegicus 142-159 35111947-7 2022 By using the collagen-induced arthritis rat model, we demonstrate that the hydrogel-camptothecin formulation could alleviate arthritis severity as indicated by the joint size and interleukin-1beta level in the harvested joints, as well as from histological and microcomputed tomography evaluation of joints. Camptothecin 84-96 interleukin 1 beta Rattus norvegicus 179-196 35002432-12 2022 The effect of Scutellarin on broncho-alveolar lavage fluid (BALF) cytokine secretion The expression of interleukins-1beta, -18 and -6 in the broncho-alveolar lavage fluid were significantly upregulated by LPS infusion (P < 0.05). scutellarin 14-25 interleukin 1 beta Rattus norvegicus 103-133