PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
22120095-10	2011	However, furosemide also decreased serum potassium concentration and increased plasma arginine vasopressin concentrations and plasma renin activity.	Furosemide	9-19	renin	Canis lupus familiaris	133-138
21621998-0	2011	Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines.	pyridone-substituted piperidines	97-129	renin	Canis lupus familiaris	0-5
19073902-2	2009	Slow sodium loading may decrease plasma renin concentration (PRC) and cause natriuresis at constant mean arterial blood pressure (MAP) and glomerular filtration rate (GFR).	Sodium	5-11	renin	Canis lupus familiaris	40-45
19042143-10	2010	Trilostane affected both the hypothalamic-pituitary-adrenocortical and the renin-aldosterone axes.	trilostane	0-10	renin	Canis lupus familiaris	75-80
19073902-3	2009	We hypothesized that in this setting, renin secretion and renin-dependent sodium excretion are controlled by via the renal nerves and therefore are eliminated or reduced by blocking the action of norepinephrine on the juxtaglomerular cells with the beta1-receptor antagonist metoprolol.	Sodium	74-80	renin	Canis lupus familiaris	58-63
19073902-3	2009	We hypothesized that in this setting, renin secretion and renin-dependent sodium excretion are controlled by via the renal nerves and therefore are eliminated or reduced by blocking the action of norepinephrine on the juxtaglomerular cells with the beta1-receptor antagonist metoprolol.	Norepinephrine	196-210	renin	Canis lupus familiaris	38-43
19073902-3	2009	We hypothesized that in this setting, renin secretion and renin-dependent sodium excretion are controlled by via the renal nerves and therefore are eliminated or reduced by blocking the action of norepinephrine on the juxtaglomerular cells with the beta1-receptor antagonist metoprolol.	Norepinephrine	196-210	renin	Canis lupus familiaris	58-63
19073902-3	2009	We hypothesized that in this setting, renin secretion and renin-dependent sodium excretion are controlled by via the renal nerves and therefore are eliminated or reduced by blocking the action of norepinephrine on the juxtaglomerular cells with the beta1-receptor antagonist metoprolol.	Metoprolol	275-285	renin	Canis lupus familiaris	38-43
19073902-3	2009	We hypothesized that in this setting, renin secretion and renin-dependent sodium excretion are controlled by via the renal nerves and therefore are eliminated or reduced by blocking the action of norepinephrine on the juxtaglomerular cells with the beta1-receptor antagonist metoprolol.	Metoprolol	275-285	renin	Canis lupus familiaris	58-63
19073902-12	2009	In conclusion, PRC depended on dietary sodium and beta1-adrenergic control as expected; however, the acute sodium-driven decrease in PRC at constant MAP and GFR was unaffected by beta1-receptor blockade demonstrating that renin may be regulated without changes in MAP, GFR, or beta1-mediated effects of norepinephrine.	Sodium	107-113	renin	Canis lupus familiaris	222-227
19073902-12	2009	In conclusion, PRC depended on dietary sodium and beta1-adrenergic control as expected; however, the acute sodium-driven decrease in PRC at constant MAP and GFR was unaffected by beta1-receptor blockade demonstrating that renin may be regulated without changes in MAP, GFR, or beta1-mediated effects of norepinephrine.	Norepinephrine	303-317	renin	Canis lupus familiaris	222-227
17293660-2	2007	As activation of the renin-angiotensin system plays an important role in this injury, we conducted this study to investigate whether administration of captopril reduced renal fibrosis in an experimental model using partial urethral obstruction (PUO) in neonatal dogs.	Captopril	151-160	renin	Canis lupus familiaris	21-26
18184767-0	2008	Stimulation of brain mast cells by compound 48/80, a histamine liberator, evokes renin and vasopressin release in dogs.	Histamine	53-62	renin	Canis lupus familiaris	81-86
18184767-10	2008	These results suggest that in dogs, endogenous histamine liberated from brain mast cells may increase renin and Epi secretion (via the sympathetic outflow) and ADH secretion (via the central nervous system).	Histamine	47-56	renin	Canis lupus familiaris	102-107
16817749-12	2006	CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that, in this rapid-evolving, dilated cardiomyopathy, activation of the renin-angiotensin system contributes to the pathophysiology of heart failure late in the disease and essentially by an activation of renal salt and water retention.	Salts	263-267	renin	Canis lupus familiaris	124-129
16817749-12	2006	CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that, in this rapid-evolving, dilated cardiomyopathy, activation of the renin-angiotensin system contributes to the pathophysiology of heart failure late in the disease and essentially by an activation of renal salt and water retention.	Water	272-277	renin	Canis lupus familiaris	124-129
16253075-2	2005	The aim of this study was to evaluate the effects of enalaprilat (Vasotec) administration on renal function during CO2 pneumoperitoneum, given that this drug, which is an angiotensin-converting enzyme inhibitor, by inhibiting the renin-angiotensin-aldosterone system, alters hormone-induced changes during pneumoperitoneum.	Enalaprilat	53-64	renin	Canis lupus familiaris	230-235
16218929-6	2005	IsoRapid caused a similar increase in sodium excretion (to 72 +/- 19 micromol min(-1)), a similar decrease in renin system activity, but a 15% elevation of RBF (282 +/- 22 to 324 +/- 35 mL min(-1)).	isorapid	0-8	renin	Canis lupus familiaris	110-115
15297251-0	2004	Unequal effects of renin-angiotensin system inhibitors in acute cardiac dysfunction induced by isoproterenol.	Isoproterenol	95-108	renin	Canis lupus familiaris	19-24
15954990-0	2005	Effects of sodium intake on plasma potassium and renin angiotensin aldosterone system in conscious dogs.	Sodium	11-17	renin	Canis lupus familiaris	49-54
15954990-2	2005	This study quantifies renin-angiotensin-aldosterone system activity as a function of sodium intake.	Sodium	85-91	renin	Canis lupus familiaris	22-27
15954990-8	2005	RESULTS: Sudden sodium intake reduction doubled plasma renin activity and angiotensin II, and tripled aldosterone on day 1 with only small non-significant additional changes on the following days.	Sodium	16-22	renin	Canis lupus familiaris	55-60
15954990-10	2005	With increasing sodium intake, plasma volume increased by 0.47 +/- 0.04 mL (kg body mass)(-1) (unit increase in Na intake)(-1) (P < 0.01), and plasma potassium decreased with the slope -0.038 mm [(mmol Na+ intake) (kg body mass)(-1) day(-1)](-1) (P = 0.001) while plasma renin-activity, angiotensin II, and aldosterone decreased systematically as expected.	Sodium	16-22	renin	Canis lupus familiaris	274-279
15954990-11	2005	CONCLUSIONS: A step reduction in sodium intake alters renin-angiotensin-aldosterone system activity on day 1 with little further change the subsequent 4 days.	Sodium	33-39	renin	Canis lupus familiaris	54-59
15954990-12	2005	Week-long increases in sodium intake decreases renin-angiotensin-aldosterone system activity, increases plasma volume, and decreases plasma potassium.	Sodium	23-29	renin	Canis lupus familiaris	47-52
15954990-13	2005	Isolated decreases in sodium intake increase aldosterone secretion via volume-mediated action on the renin-angiotensin system and via increases in plasma potassium.	Sodium	22-28	renin	Canis lupus familiaris	101-106
15736855-10	2005	The data indicate that CsA increased blood pressure, which may be due to decreased baroreceptor reflex sensitivity mediated via activation of the renin-angiotensin-aldosterone system.	Cyclosporine	23-26	renin	Canis lupus familiaris	146-151
12832717-0	2003	Nifedipine inhibits the hypoxia-induced decrease in plasma renin activity in conscious dogs.	Nifedipine	0-10	renin	Canis lupus familiaris	59-64
15550787-0	2004	The differential role of exogenous and endogenous prostacyclin in the control of renin release from dog renal cortical slices.	Epoprostenol	50-62	renin	Canis lupus familiaris	81-86
15550787-1	2004	Using a continuous superfusion system of dog renal cortical slices, we studied the role of prostacyclin in the control of renin release.	Epoprostenol	91-103	renin	Canis lupus familiaris	122-127
15550787-3	2004	Exogenous prostacyclin (0.1, 1, 10 microM) produced a concentration dependent and significant increase in renin release.	Epoprostenol	10-22	renin	Canis lupus familiaris	106-111
15550787-4	2004	The calcium ionophore A23187 (10 microM) produced a significant increase in 6-keto-prostaglandin F1alpha release and a significant decrease in renin release.	Calcium	4-11	renin	Canis lupus familiaris	143-148
15550787-4	2004	The calcium ionophore A23187 (10 microM) produced a significant increase in 6-keto-prostaglandin F1alpha release and a significant decrease in renin release.	Calcimycin	22-28	renin	Canis lupus familiaris	143-148
15550787-7	2004	On the other hand, the inhibitory effect of A23187 on renin release in the pretreatment with indomethacin was almost equal to that in the "untreatment" with indomethacin.	Calcimycin	44-50	renin	Canis lupus familiaris	54-59
15550787-7	2004	On the other hand, the inhibitory effect of A23187 on renin release in the pretreatment with indomethacin was almost equal to that in the "untreatment" with indomethacin.	Indomethacin	93-105	renin	Canis lupus familiaris	54-59
14620551-4	2003	In the dogs with PDH the renin activity increased significantly after the administration of dexamethasone.	Dexamethasone	92-105	renin	Canis lupus familiaris	25-30
15550787-9	2004	These results indicate that exogenous prostacyclin promotes renin release, and suggest that renin release is not to be modulated by A23187-induced prostacyclin synthesis in dog renal cortical slices.	Epoprostenol	38-50	renin	Canis lupus familiaris	60-65
12832717-1	2003	Acute hypoxia induces a decrease in plasma renin activity (PRA), mediated, e.g., by an increase in adenosine concentration, calcium channel activity, or inhibition of ATP-sensitive potassium channels.	Adenosine	99-108	renin	Canis lupus familiaris	43-48
12498925-2	2003	The calcium ionophore A23187 (10 microM) produced a significant decrease in renin release.	Calcium	4-11	renin	Canis lupus familiaris	76-81
12498925-2	2003	The calcium ionophore A23187 (10 microM) produced a significant decrease in renin release.	Calcimycin	22-28	renin	Canis lupus familiaris	76-81
12498925-5	2003	The beta-adrenoceptor agonist isoproterenol (1, 10 and 100 microM) produced a concentration-dependent increase in renin release.	Isoproterenol	30-43	renin	Canis lupus familiaris	114-119
12498925-6	2003	Pretreatment with W-7 (20 microM) potentiated the stimulation of renin release induced by isoproterenol (1 microM).	W 7	18-21	renin	Canis lupus familiaris	65-70
12498925-6	2003	Pretreatment with W-7 (20 microM) potentiated the stimulation of renin release induced by isoproterenol (1 microM).	Isoproterenol	90-103	renin	Canis lupus familiaris	65-70
12498925-7	2003	These results suggest that A23187-induced inhibition of renin release is mediated by the activation of calmodulin via an increase in intracellular Ca(2+) and beta-adrenoceptor-stimulated renin release is modulated by intracellular Ca(2+) mobilization.	Calcimycin	27-33	renin	Canis lupus familiaris	56-61
12498925-7	2003	These results suggest that A23187-induced inhibition of renin release is mediated by the activation of calmodulin via an increase in intracellular Ca(2+) and beta-adrenoceptor-stimulated renin release is modulated by intracellular Ca(2+) mobilization.	Calcimycin	27-33	renin	Canis lupus familiaris	187-192
11903508-2	2002	The present study was undertaken to clarify whether the renin-angiotensin system contributes to the development of this pressor response to L-NNA.	Nitroarginine	140-145	renin	Canis lupus familiaris	56-61
11903508-5	2002	The acute pressor response produced by the intravenous administration of L-NNA was accompanied by reduced renin activity in both systemic and renal vascular beds.	Nitroarginine	73-78	renin	Canis lupus familiaris	106-111
10444563-0	1999	Pressure-dependent renin release: effects of sodium intake and changes of total body sodium.	Sodium	45-51	renin	Canis lupus familiaris	19-24
11299275-0	2001	Evidence that the renin decrease during hypoxia is adenosine mediated in conscious dogs.	Adenosine	51-60	renin	Canis lupus familiaris	18-23
11299275-1	2001	This study investigated whether adenosine mediates the decrease in plasma renin activity (PRA) during acute hypoxia.	Adenosine	32-41	renin	Canis lupus familiaris	74-79
11299275-11	2001	Thus infusion of the adenosine receptor antagonist theophylline inhibited the suppression of the renin-angiotensin system during acute hypoxia.	Theophylline	51-63	renin	Canis lupus familiaris	97-102
11318960-4	2001	In contrast, dietary sodium loading induced a marked increase in cAT1 receptor expression in both the glomeruli and adrenal compared with receptor expression in salt-restricted animals [H/L ratio: glomeruli (1.5), renal medulla (1.1), adrenal (1.6)] that inversely correlated with the activity of the plasma renin angiotensin system.	Sodium	21-27	renin	Canis lupus familiaris	308-313
10892656-1	2000	Carperitide, a recombinant form of alpha-hANP, possesses potent diuretic, natriuretic, and vasodilatory activity, and inhibits the renin-aldosterone system and sympathetic nervous activity.	NPPA protein, human	0-11	renin	Canis lupus familiaris	131-136
10555096-6	1999	This 66% fall in renin secretion was associated with significant (P < 0.05) increases in creatinine clearance (40%), renal blood flow (8%), urine flow (50%), and sodium excretion (17%).	Creatinine	92-102	renin	Canis lupus familiaris	17-22
10555096-6	1999	This 66% fall in renin secretion was associated with significant (P < 0.05) increases in creatinine clearance (40%), renal blood flow (8%), urine flow (50%), and sodium excretion (17%).	Sodium	165-171	renin	Canis lupus familiaris	17-22
10555096-7	1999	CONCLUSIONS: It is suggested that this inhibition of renin secretion was mediated, at least in part, in response to a ProANF31-67-induced increment in the sodium load delivered to the macula densa.	Sodium	155-161	renin	Canis lupus familiaris	53-58
11703026-6	2001	RESULTS: Furosemide treatment significantly decreased plasma Cl concentration and significantly increased plasma renin activity and aldosterone concentration.	Furosemide	9-19	renin	Canis lupus familiaris	113-118
11703026-8	2001	A significant interaction between a low Na diet and furosemide administration resulted in the lowest plasma Cl concentrations, highest plasma renin activities, and highest plasma aldosterone concentrations.	Furosemide	52-62	renin	Canis lupus familiaris	142-147
11703026-9	2001	CONCLUSIONS AND CLINICAL RELEVANCE: In healthy dogs, feeding a low Na diet and administering furosemide resulted in an additive effect on plasma Cl concentration, renin activity, and aldosterone concentration, which may be an important consideration for treating dogs with cardiac disease.	Furosemide	93-103	renin	Canis lupus familiaris	163-168
11400857-1	2001	OBJECTIVE: To evaluate the effect of dilated cardiomyopathy (DCM) on activity of the renin-angiotensin-aldosterone system (RAAS), the N-terminal fragment of proatrial natriuretic peptide (NT-proANP), and thyroid hormone concentrations in dogs.	nt-proanp	188-197	renin	Canis lupus familiaris	85-90
11373336-6	2001	In a first set of experiments, a nonpressor dose of L-Nomega-nitroarginine (LN) (3 microg/min per kg body wt) was administered, to prevent increases in mean arterial BP and thus pressure effects on renin release and natriuresis.	l-nomega-nitroarginine	52-74	renin	Canis lupus familiaris	198-203
11451212-8	2001	Oral olmesartan medoxomil exhibits dose-dependent antihypertensive effects in several rat and dog models, with the most marked effects seen in high plasma renin models, when compared with normal or low renin types.	olmesartan	5-15	renin	Canis lupus familiaris	155-160
11451212-8	2001	Oral olmesartan medoxomil exhibits dose-dependent antihypertensive effects in several rat and dog models, with the most marked effects seen in high plasma renin models, when compared with normal or low renin types.	medoxomil	16-25	renin	Canis lupus familiaris	155-160
11304508-12	2001	Third, DNP increased plasma and urinary cGMP and suppressed plasma renin activity.	Dendroaspis natriuretic peptide	7-10	renin	Canis lupus familiaris	67-72
11213032-10	2001	Reflex elevation of plasma renin activity induced by 1 mg/kg of E-3174 was similar to that caused by 1 mg/kg of enalapril, suggesting that the two drugs achieved similar inhibition of the endogenous renin angiotensin system.	losartan carboxylic acid	64-70	renin	Canis lupus familiaris	27-32
10444563-0	1999	Pressure-dependent renin release: effects of sodium intake and changes of total body sodium.	Sodium	85-91	renin	Canis lupus familiaris	19-24
10444563-1	1999	The impact of sodium intake and changes in total body sodium (TBS) for the setting of pressure-dependent renin release (PDRR) was studied in freely moving dogs.	Sodium	14-20	renin	Canis lupus familiaris	105-110
10444563-1	1999	The impact of sodium intake and changes in total body sodium (TBS) for the setting of pressure-dependent renin release (PDRR) was studied in freely moving dogs.	Sodium	54-60	renin	Canis lupus familiaris	105-110
10444563-1	1999	The impact of sodium intake and changes in total body sodium (TBS) for the setting of pressure-dependent renin release (PDRR) was studied in freely moving dogs.	tribromsalan	62-65	renin	Canis lupus familiaris	105-110
10444563-9	1999	Thus an inverse relationship between TBS and PRA, i.e., a TBS-dependent renin release, was found.	tribromsalan	37-40	renin	Canis lupus familiaris	72-77
10444563-9	1999	Thus an inverse relationship between TBS and PRA, i.e., a TBS-dependent renin release, was found.	tribromsalan	58-61	renin	Canis lupus familiaris	72-77
10444563-11	1999	This interplay between TBS-dependent renin release and PDRR allows the organism a differentiated reaction to changes in TBS and arterial pressure.	tribromsalan	23-26	renin	Canis lupus familiaris	37-42
9674634-3	1998	Meclofenamate infusion (5 microg x kg(-1) x min(-1)) during 4 consecutive days (n=8) elicited a continuous decrease (P<0.05) in renal blood flow and plasma renin activity and a transitory decrease in sodium excretion.	Meclofenamic Acid	0-13	renin	Canis lupus familiaris	159-164
10326661-2	1999	This study was designed to assess the influence of the activation status of the renin angiotensin system (RAS) on the hemodynamic effects of EXP 3174 (an angiotensin AT1 receptor antagonist) and enalaprilat (an angiotensin converting enzyme inhibitor) in tachycardia-induced heart failure.	Enalaprilat	195-206	renin	Canis lupus familiaris	80-85
10355696-8	1999	We propose, further that the endogenous cardiac renin-angiotensin II system (blocked by saralasin, captopril and by chymostatin) is an important contributor to the induction of memory.	Saralasin	88-97	renin	Canis lupus familiaris	48-53
10355696-8	1999	We propose, further that the endogenous cardiac renin-angiotensin II system (blocked by saralasin, captopril and by chymostatin) is an important contributor to the induction of memory.	Captopril	99-108	renin	Canis lupus familiaris	48-53
10355696-8	1999	We propose, further that the endogenous cardiac renin-angiotensin II system (blocked by saralasin, captopril and by chymostatin) is an important contributor to the induction of memory.	chymostatin	116-127	renin	Canis lupus familiaris	48-53
10076917-7	1999	Enalapril increased plasma renin activity more strongly than did candesartan cilexetil, and significantly decreased vascular and plasma ACE activities.	Enalapril	0-9	renin	Canis lupus familiaris	27-32
9674634-4	1998	NG-Nitro-L-arginine methyl ester (L-NAME) infusion (5 microg x kg(-1) x min(-1)) during 6 days (n=8) produced a significant increase in arterial pressure and a transitory decrease (P<0.05) in both renal blood flow and plasma renin activity.	NG-Nitroarginine Methyl Ester	0-32	renin	Canis lupus familiaris	228-233
9674634-4	1998	NG-Nitro-L-arginine methyl ester (L-NAME) infusion (5 microg x kg(-1) x min(-1)) during 6 days (n=8) produced a significant increase in arterial pressure and a transitory decrease (P<0.05) in both renal blood flow and plasma renin activity.	NG-Nitroarginine Methyl Ester	34-40	renin	Canis lupus familiaris	228-233
9674634-7	1998	Only a transitory decrease in plasma renin activity was found during meclofenamate infusion in this group.	Meclofenamic Acid	69-82	renin	Canis lupus familiaris	37-42
9641474-1	1998	We determined the effects of the K-adenosine triphosphate (ATP)-blocking diuretic PNU-37883A on plasma renin activity (PRA) in conscious and anesthetized dogs.	Adenosine Triphosphate	59-62	renin	Canis lupus familiaris	103-108
9641474-1	1998	We determined the effects of the K-adenosine triphosphate (ATP)-blocking diuretic PNU-37883A on plasma renin activity (PRA) in conscious and anesthetized dogs.	N-neopentyl-N-nitrosourea	82-85	renin	Canis lupus familiaris	103-108
9475264-21	1998	The in vivo coronary vascular response to S-NO-Cap may, therefore, be partially reduced by activation of the adrenergic or renin-angiotensin-aldosterone systems or both induced by NTG, because S-NO-Cap showed no cross-tolerance with NTG in our earlier in vitro study.	Nitroglycerin	180-183	renin	Canis lupus familiaris	123-128
8898005-11	1996	These data suggest that the renin-angiotensin system tonically stimulates renal BK production and cGMP formation via a non-AT1 angiotensin receptor and renal PGE2 production via the AT1 receptor.	Cyclic GMP	98-102	renin	Canis lupus familiaris	28-33
9234664-9	1997	In the 15-day repeated oral-administration study, KRN4884 (0.1 mg/kg) induced sustained hypotensive effects and transient increases in HR and plasma renin activity.	KRN 4884	50-57	renin	Canis lupus familiaris	149-154
9234664-13	1997	These data indicate that KRN4884 produces a strong and persistent antihypertensive response in both low-renin and high-renin models of RHD in a conscious state, which suggests that KRN4884 may be useful as an antihypertensive agent.	KRN 4884	25-32	renin	Canis lupus familiaris	104-109
9234664-13	1997	These data indicate that KRN4884 produces a strong and persistent antihypertensive response in both low-renin and high-renin models of RHD in a conscious state, which suggests that KRN4884 may be useful as an antihypertensive agent.	KRN 4884	25-32	renin	Canis lupus familiaris	119-124
9087651-1	1997	Because endothelium-derived factors are known to have multiple actions throughout the body, the role of nitric oxide (NO) produced within the kidney in the regulation of renin release is still unclear.	Nitric Oxide	104-116	renin	Canis lupus familiaris	170-175
9653807-18	1997	Propranolol produced a major activation of the renin-angiotensin system and of the cortical blood flow in ischemic cephalic hypoxia, the renin-angiotensin system being located in the cerebral structure.	Propranolol	0-11	renin	Canis lupus familiaris	47-52
9653807-18	1997	Propranolol produced a major activation of the renin-angiotensin system and of the cortical blood flow in ischemic cephalic hypoxia, the renin-angiotensin system being located in the cerebral structure.	Propranolol	0-11	renin	Canis lupus familiaris	137-142
8997612-1	1996	The role of the renin-angiotensin system in the haemodynamic changes induced by acute administration of N omega-nitro-L-arginine methyl ester in anaesthetised dogs was investigated.	NG-Nitroarginine Methyl Ester	104-141	renin	Canis lupus familiaris	16-21
8915446-0	1996	Effects of long-term treatment with enalapril or hydralazine on the renin-angiotensin-aldosterone system and fluid balance in dogs with naturally acquired mitral valve regurgitation.	Enalapril	36-45	renin	Canis lupus familiaris	68-73
8915446-0	1996	Effects of long-term treatment with enalapril or hydralazine on the renin-angiotensin-aldosterone system and fluid balance in dogs with naturally acquired mitral valve regurgitation.	Hydralazine	49-60	renin	Canis lupus familiaris	68-73
8915446-1	1996	OBJECTIVE: To study long-term effects of enalapril, an angiotensin-converting enzyme inhibitor, and hydralazine, an arteriodilator, on renin-angiotensin-aldosterone system and fluid balance before and after administration of furosemide.	Hydralazine	100-111	renin	Canis lupus familiaris	135-140
9277550-10	1997	It is concluded that 1) endogenous downregulation of components of the renin-angiotensin-aldosterone system is a pivotal compensatory mechanism to reduce Na and water retention and 2) natriuretic and diuretic factors seem to be of minor potency, because not even the sum of all could counterbalances the Na- and water-retaining effects of Aldo and ANG II.	Water	161-166	renin	Canis lupus familiaris	71-76
9277550-10	1997	It is concluded that 1) endogenous downregulation of components of the renin-angiotensin-aldosterone system is a pivotal compensatory mechanism to reduce Na and water retention and 2) natriuretic and diuretic factors seem to be of minor potency, because not even the sum of all could counterbalances the Na- and water-retaining effects of Aldo and ANG II.	Water	312-317	renin	Canis lupus familiaris	71-76
9231029-9	1997	CONCLUSIONS: Renin inhibition with CP80794 and ACEI with captopril caused comparable hemodynamic effects in advanced CHF.	terlakiren	35-42	renin	Canis lupus familiaris	13-18
9231029-9	1997	CONCLUSIONS: Renin inhibition with CP80794 and ACEI with captopril caused comparable hemodynamic effects in advanced CHF.	Captopril	57-66	renin	Canis lupus familiaris	13-18
9231029-10	1997	However, CP80794 caused significantly greater increases in renal blood flow and suppressed renin activity to a greater degree than captopril.	terlakiren	9-16	renin	Canis lupus familiaris	91-96
8952593-8	1996	Atrial natriuretic factor, however, increased at 7 and 14 days of servo-controlled norepinephrine, and plasma renin activity increased on day 14 of norepinephrine infusion.	Norepinephrine	148-162	renin	Canis lupus familiaris	110-115
8898005-11	1996	These data suggest that the renin-angiotensin system tonically stimulates renal BK production and cGMP formation via a non-AT1 angiotensin receptor and renal PGE2 production via the AT1 receptor.	Dinoprostone	158-162	renin	Canis lupus familiaris	28-33
8569232-0	1995	Acute hemodynamic effects of ciprokiren, a novel renin inhibitor, in sodium-depleted dogs.	ciprokiren	29-39	renin	Canis lupus familiaris	49-54
8717064-2	1996	The effects of dietary sodium intake on active renin binding in the juxtaglomerular apparatus (JGA) of superficial and juxtamedullary cortex of the dog kidney were examined by quantitative in vitro autoradiography using a radiolabelled renin inhibitor [125I]-H77, which has high affinity for dog renin.	Sodium	23-29	renin	Canis lupus familiaris	47-52
8717064-4	1996	Changes in sodium intake resulted in marked alterations of active renin binding in the radiolabelled JGA.	Sodium	11-17	renin	Canis lupus familiaris	66-71
8717064-7	1996	Active renin binding in the labelled JGA was significantly higher in superficial JGA than in their juxtamedullary counterparts, irrespective of sodium intake.	Sodium	144-150	renin	Canis lupus familiaris	7-12
8717064-10	1996	The proportions of active renin as a percentage of total renin were 60, 75 and 95% in the labelled JGA of sodium-loaded, control, and sodium-depleted kidneys, respectively.	Sodium	106-112	renin	Canis lupus familiaris	26-31
8964947-0	1996	Changes of blood pressure, sodium excretion and sodium balance due to variations of the renin-angiotensin-aldosterone system.	Sodium	27-33	renin	Canis lupus familiaris	88-93
8964947-0	1996	Changes of blood pressure, sodium excretion and sodium balance due to variations of the renin-angiotensin-aldosterone system.	Sodium	48-54	renin	Canis lupus familiaris	88-93
8964947-15	1996	Furthermore, these results demonstrate that rRPP-induced increases of total body Na and MABP are solely mediated by the activation of the renin-angiotensin-aldosterone system.	rrpp	44-48	renin	Canis lupus familiaris	138-143
8666025-10	1995	These results suggest that, in addition to vasoconstriction due to the inhibition of endothelial nitric oxide production, increased activity of the sympathetic nervous and renin-angiotensin systems contributes significantly to the development of pressor responses produced by the intravenous injection of L-NNA in anesthetized dogs.	Nitroarginine	305-310	renin	Canis lupus familiaris	172-177
12836713-7	1995	Neurohumoral factors were similar in both groups except for the expected high plasma renin activity in enalapril-treated dogs.	Enalapril	103-112	renin	Canis lupus familiaris	85-90
8866902-4	1995	RESULTS: Acute intravenous administration of captopril improved the cardiac output by 19% (P < 0.01) but losartan did not, although blockade of the renin-angiotensin system by losartan (1.1 mumol/kg) or captopril (0.69 mumol/kg) induced similar changes in the plasma renin activity, norepinephrine and arginine vasopressin, and a similar decrease in mean arterial pressure (-10 mmHg).	Captopril	45-54	renin	Canis lupus familiaris	151-156
8866902-4	1995	RESULTS: Acute intravenous administration of captopril improved the cardiac output by 19% (P < 0.01) but losartan did not, although blockade of the renin-angiotensin system by losartan (1.1 mumol/kg) or captopril (0.69 mumol/kg) induced similar changes in the plasma renin activity, norepinephrine and arginine vasopressin, and a similar decrease in mean arterial pressure (-10 mmHg).	Captopril	45-54	renin	Canis lupus familiaris	270-275
8564246-7	1995	Intracisternal acetylcholine also increased noradrenaline, adrenaline and vasopressin plasma levels, decreased plasma renin activity but did not modify plasma levels of neuropeptide Y and atrial natriuretic factor.	Acetylcholine	15-28	renin	Canis lupus familiaris	118-123
8569232-7	1995	At 0.1 mg/kg ciprokiren, arterial BP was reduced, with no change in PRA, showing the dissociation between hemodynamic effects and inhibition of renin in plasma.	ciprokiren	13-23	renin	Canis lupus familiaris	144-149
8569232-8	1995	Acutely, renin inhibition with ciprokiren produces a marked peripheral vasodilation which appears to be dissociated from the renin inhibition in plasma and which is not increased by additional ACE inhibition.	ciprokiren	31-41	renin	Canis lupus familiaris	9-14
7675125-7	1995	(-)-Ozolinone also induced an acute rise in renin secretion.	ozolinone	0-13	renin	Canis lupus familiaris	44-49
8564219-8	1995	In dogs with intact autonomic reflexes, 2-methoxyidazoxan (15 micrograms kg-1 plus 0.6 micrograms kg-1 min-1) produced effects consistent with a generalized increase in sympathetic drive, including increases in mean arterial pressure and plasma renin activity, and a reduction in sodium excretion.	2-methoxyidazoxan	40-57	renin	Canis lupus familiaris	245-250
8564890-1	1995	This study was designed to determine if tonic beta-adrenergic control of plasma renin activity (PRA) during dietary sodium restriction is due to stimulation of renal beta-adrenoceptors, extrarenal beta-adrenoceptors, or both.	Sodium	116-122	renin	Canis lupus familiaris	80-85
7607739-3	1995	Oral dosing with SC-56525 at 3, 10, and 30 mg/kg in salt-depleted dogs induced a dose-dependent reduction in mean arterial pressure and inhibition of plasma renin activity with no significant effect on heart rate.	SC 56525	17-25	renin	Canis lupus familiaris	157-162
7607739-6	1995	SC-56525 is a nanomolar, orally active inhibitor of renin and effectively lowers blood pressure in both salt-depleted and renal hypertensive dogs.	SC 56525	0-8	renin	Canis lupus familiaris	52-57
7675125-8	1995	The inhibition of prostaglandin synthesis (indomethacin or meclofenamate) prevented renin hypersecretion in response to (-)-ozolinone and modified its salidiuretic effects but had no effect on the vascular response.	Prostaglandins	18-31	renin	Canis lupus familiaris	84-89
7675125-8	1995	The inhibition of prostaglandin synthesis (indomethacin or meclofenamate) prevented renin hypersecretion in response to (-)-ozolinone and modified its salidiuretic effects but had no effect on the vascular response.	Indomethacin	43-55	renin	Canis lupus familiaris	84-89
7675125-8	1995	The inhibition of prostaglandin synthesis (indomethacin or meclofenamate) prevented renin hypersecretion in response to (-)-ozolinone and modified its salidiuretic effects but had no effect on the vascular response.	Meclofenamic Acid	59-72	renin	Canis lupus familiaris	84-89
7675125-8	1995	The inhibition of prostaglandin synthesis (indomethacin or meclofenamate) prevented renin hypersecretion in response to (-)-ozolinone and modified its salidiuretic effects but had no effect on the vascular response.	ozolinone	120-133	renin	Canis lupus familiaris	84-89
7675125-10	1995	The inhibition of the renin-angiotensin system by captopril decreased blood pressure, prolonged the (-)-ozolinone-induced decrease in renal vascular resistance and increased renin secretion.	Captopril	50-59	renin	Canis lupus familiaris	22-27
7675125-10	1995	The inhibition of the renin-angiotensin system by captopril decreased blood pressure, prolonged the (-)-ozolinone-induced decrease in renal vascular resistance and increased renin secretion.	Captopril	50-59	renin	Canis lupus familiaris	174-179
7675125-10	1995	The inhibition of the renin-angiotensin system by captopril decreased blood pressure, prolonged the (-)-ozolinone-induced decrease in renal vascular resistance and increased renin secretion.	ozolinone	100-113	renin	Canis lupus familiaris	22-27
7675125-10	1995	The inhibition of the renin-angiotensin system by captopril decreased blood pressure, prolonged the (-)-ozolinone-induced decrease in renal vascular resistance and increased renin secretion.	ozolinone	100-113	renin	Canis lupus familiaris	174-179
7675125-11	1995	Our results demonstrate that the loop diuretic, ozolinone, induces stereoselective and prostaglandin-dependent renin secretion, which is involved in the regulation of intra-renal hemodynamics.	ozolinone	48-57	renin	Canis lupus familiaris	111-116
7675125-11	1995	Our results demonstrate that the loop diuretic, ozolinone, induces stereoselective and prostaglandin-dependent renin secretion, which is involved in the regulation of intra-renal hemodynamics.	Prostaglandins	87-100	renin	Canis lupus familiaris	111-116
7895605-0	1994	The orally active renin inhibitor A-74273.	A 74273	34-41	renin	Canis lupus familiaris	18-23
7737731-3	1995	During the first 60 minutes of norepinephrine infusion in control dogs, mean arterial pressure increased 9 +/- 4 mm Hg in association with a twofold to threefold rise in plasma renin activity.	Norepinephrine	31-45	renin	Canis lupus familiaris	177-182
7760655-7	1995	Test group 3 (HTK/tryptophan) differed from the others in having further improved renin values.	Tryptophan	18-28	renin	Canis lupus familiaris	82-87
7626181-11	1995	This effect may, at least in part, be ascribed to inhibition of the breakdown and disposal of endogenous adenosine which, in turn, inhibits the excessive stimulation of the renin-angiotensin system in the early phase of reperfusion.	Adenosine	105-114	renin	Canis lupus familiaris	173-178
7810724-3	1994	Oral administration of the selective AVP V2 receptor antagonist OPC-31260 induced marked water diuresis, which resulted in significant increases in serum sodium concentration, plasma renin activity, and plasma concentration of AVP, although it did not produce hemodynamic improvement.	mozavaptan	64-73	renin	Canis lupus familiaris	183-188
7737709-4	1995	Changes in renal interstitial and plasma angiotensins in response to interstitial administration of a specific renin inhibitor, ACRIP (0.5 micrograms/kg per minute for 20 minutes), were monitored on day 5 of sodium depletion.	renin inhibitory peptide, 4-amino-5-cyclohexyl-3-hydroxypentanoic acid	128-133	renin	Canis lupus familiaris	111-116
7737709-9	1995	Renal interstitial immunoreactive angiotensin decreased significantly to 124 +/- 37 nmol (P < .01) in response to intrarenal renin inhibition at the end of day 5 of sodium depletion.	Sodium	168-174	renin	Canis lupus familiaris	128-133
7805235-0	1995	Dose-dependent effects of the renin inhibitor zankiren HCl after a single oral dose in mildly sodium-depleted normotensive subjects.	zankiren hydrochloride	46-58	renin	Canis lupus familiaris	30-35
7805235-1	1995	BACKGROUND: Zankiren HCl (A-72517) is a potent renin inhibitor shown to have substantial bioavailability in several animal species and to produce dose-related reductions in blood pressure, plasma renin activity, and angiotensin II (Ang II) in salt-depleted dogs.	zankiren hydrochloride	12-24	renin	Canis lupus familiaris	47-52
7805235-1	1995	BACKGROUND: Zankiren HCl (A-72517) is a potent renin inhibitor shown to have substantial bioavailability in several animal species and to produce dose-related reductions in blood pressure, plasma renin activity, and angiotensin II (Ang II) in salt-depleted dogs.	zankiren hydrochloride	12-24	renin	Canis lupus familiaris	196-201
7805235-1	1995	BACKGROUND: Zankiren HCl (A-72517) is a potent renin inhibitor shown to have substantial bioavailability in several animal species and to produce dose-related reductions in blood pressure, plasma renin activity, and angiotensin II (Ang II) in salt-depleted dogs.	zankiren hydrochloride	26-33	renin	Canis lupus familiaris	47-52
7805235-1	1995	BACKGROUND: Zankiren HCl (A-72517) is a potent renin inhibitor shown to have substantial bioavailability in several animal species and to produce dose-related reductions in blood pressure, plasma renin activity, and angiotensin II (Ang II) in salt-depleted dogs.	zankiren hydrochloride	26-33	renin	Canis lupus familiaris	196-201
7932521-4	1994	Computer modeling of A-74273 bound to renin indicated that the C-terminus was involved in a hydrogen-bonding network.	Hydrogen	92-100	renin	Canis lupus familiaris	38-43
7932521-6	1994	Those groups which possessed multiple hydrogen-bonding ability (3,5-diaminotriazole, cyanoguanidines, morpholino) provided particularly potent renin binding.	Hydrogen	38-46	renin	Canis lupus familiaris	143-148
7932521-6	1994	Those groups which possessed multiple hydrogen-bonding ability (3,5-diaminotriazole, cyanoguanidines, morpholino) provided particularly potent renin binding.	3,5-diaminotriazole	64-83	renin	Canis lupus familiaris	143-148
7932521-6	1994	Those groups which possessed multiple hydrogen-bonding ability (3,5-diaminotriazole, cyanoguanidines, morpholino) provided particularly potent renin binding.	dicyandiamido	85-100	renin	Canis lupus familiaris	143-148
7932521-6	1994	Those groups which possessed multiple hydrogen-bonding ability (3,5-diaminotriazole, cyanoguanidines, morpholino) provided particularly potent renin binding.	Morpholinos	102-112	renin	Canis lupus familiaris	143-148
7932521-10	1994	We report here the discovery of a series of efficacious nonpeptide renin inhibitors based on the 3-azaglutaramide P2-P4 replacement, the best of which showed id bioavailabilities > 50% in dog.	3-azaglutaramide p2-p4	97-119	renin	Canis lupus familiaris	67-72
7505369-0	1993	Cardiovascular effects and hemodynamic mechanism of action of the novel, nonpeptidic renin inhibitor A-74273 in dogs.	A 74273	101-108	renin	Canis lupus familiaris	85-90
7920458-0	1994	CP-71,362: a pentapeptide renin inhibitor selective for the canine enzyme.	cp-71	0-5	renin	Canis lupus familiaris	26-31
8091887-1	1994	The purpose of the present study was to quantify some of the short term responses of the renin-angiotensin system (RAS) to a recommended dosage of the angiotensin-converting enzyme inhibitor enalapril in clinically healthy dogs fed a normal-sodium and a low-sodium diet.	Enalapril	191-200	renin	Canis lupus familiaris	89-94
8091887-4	1994	The data indicate that enalapril induced a potent blockade of the renin-angiotensin system (RAS) for at least twenty-four hour.	Enalapril	23-32	renin	Canis lupus familiaris	66-71
8282380-9	1994	Associated with the attenuated natriuretic response to renal perfusion pressure in the obese dogs were significant elevations in plasma renin activity (4.3 +/- 1.6 versus 1.6 +/- 0.5 ng angiotensin I/mL per hour), plasma aldosterone concentration (34.4 +/- 6.4 versus 15.3 +/- 3.2 ng/dL), and plasma insulin concentration (30.5 +/- 6.8 versus 20.9 +/- 2.9 IU/mL).	Aldosterone	221-232	renin	Canis lupus familiaris	136-141
8201530-0	1994	Pharmacokinetics and cardiovascular effects of YM-21095, a novel renin inhibitor, in dogs and monkeys.	YM 21095	47-55	renin	Canis lupus familiaris	65-70
8201530-8	1994	At equihypotensive doses, captopril and nicardipine increased plasma renin activity markedly and slightly, respectively.	Captopril	26-35	renin	Canis lupus familiaris	69-74
8201530-8	1994	At equihypotensive doses, captopril and nicardipine increased plasma renin activity markedly and slightly, respectively.	Nicardipine	40-51	renin	Canis lupus familiaris	69-74
7976412-10	1994	It is concluded that the natriuretic mechanisms activated by a selective increase in the Na+ concentration of carotid blood and associated with increased excretion of urodilatin cannot be eliminated by blockade of the renin-angiotensin-aldosterone system.	Ularitide	167-177	renin	Canis lupus familiaris	218-223
7965274-11	1994	CONCLUSIONS: These studies provide further evidence of the importance of the renal renin-angiotensin system in mediating the renal vasoconstrictor actions of endothelin and indicate the therapeutic potential for quinapril in opposing the actions of endothelin in states of excessive endothelin activation.	Quinapril	212-221	renin	Canis lupus familiaris	83-88
7942378-0	1994	Some effects of a low sodium diet high in potassium on the renin-angiotensin system and plasma electrolyte concentrations in normal dogs.	Potassium	42-51	renin	Canis lupus familiaris	59-64
7505369-1	1993	A-74273 is a nonpeptidic, potent inhibitor of human and canine renin (IC50 = 3.1 and 43 nM, respectively, in plasma at pH 7.4) and has been shown to be orally active in dogs.	A 74273	0-7	renin	Canis lupus familiaris	63-68
7505369-5	1993	Baseline mean arterial pressure (MAP) was similar among all treatment groups, but baseline plasma renin activity (PRA) was increased in the sodium-depleted dogs as compared with the sodium-replete dogs.	Sodium	140-146	renin	Canis lupus familiaris	98-103
8102503-6	1993	After propranolol administration ureteral occlusion increased renin release from 5 +/- 2 micrograms AI min-1 to 38 +/- 12 micrograms AI min-1 in six dogs.	Propranolol	6-17	renin	Canis lupus familiaris	62-67
8368393-5	1993	During losartan (n = 6) and captopril (n = 5) infusion, plasma renin responses were enhanced in response to 14% BVD (1.93 +/- 0.48 to 5.74 +/- 2.25 and 3.03 +/- 0.73 to 9.19 +/- 1.94 ng ANG I.ml-1 x h-1, respectively), whereas antinatriuretic responses were similar to vehicle-infused dogs.	Losartan	7-15	renin	Canis lupus familiaris	63-68
8368393-5	1993	During losartan (n = 6) and captopril (n = 5) infusion, plasma renin responses were enhanced in response to 14% BVD (1.93 +/- 0.48 to 5.74 +/- 2.25 and 3.03 +/- 0.73 to 9.19 +/- 1.94 ng ANG I.ml-1 x h-1, respectively), whereas antinatriuretic responses were similar to vehicle-infused dogs.	Captopril	28-37	renin	Canis lupus familiaris	63-68
8368393-7	1993	Tonic intrarenal and/or circulating ANG II synthesis of dogs on a normal sodium diet inhibit neurogenic stimulation of renin release, since PRA responses were enhanced after blockade of ANG II.	Sodium	73-79	renin	Canis lupus familiaris	119-124
8374609-2	1993	In the present study, the renin inhibitor PD 132002 was given to salt-deplete, anesthetized dogs.	PD 132002	42-51	renin	Canis lupus familiaris	26-31
8217033-0	1993	Mechanisms of ozolinone-induced renin release and diuresis.	ozolinone	14-23	renin	Canis lupus familiaris	32-37
8217033-11	1993	The data are consistent with the proposal that the effect of (-)ozo on renin secretion and PRA is through a PG-dependent mechanism, and that it requires an intact macula densa mechanism.	pg	108-110	renin	Canis lupus familiaris	71-76
8102503-9	1993	Subsequent infusion of isoproterenol (0.2 microgram min-1 kg-1 body wt) to stimulate beta-adrenoceptor activity increased renin release from 13 +/- 4 micrograms AI min-1 to 68 +/- 8 micrograms AI min-1 during ureteral occlusion.	Isoproterenol	23-36	renin	Canis lupus familiaris	122-127
8322896-1	1993	The effect of blocking the formation of endothelium-derived relaxing factor/nitric oxide (EDNO) on pressure-dependent renin release (RR) was studied in six conscious foxhounds with chronically implanted catheters in the abdominal aorta and the renal vein.	Nitric Oxide	76-88	renin	Canis lupus familiaris	118-123
8322896-1	1993	The effect of blocking the formation of endothelium-derived relaxing factor/nitric oxide (EDNO) on pressure-dependent renin release (RR) was studied in six conscious foxhounds with chronically implanted catheters in the abdominal aorta and the renal vein.	edno	90-94	renin	Canis lupus familiaris	118-123
1452292-0	1992	Discovery of a well-absorbed, efficacious renin inhibitor, A-74273.	A 74273	59-66	renin	Canis lupus familiaris	42-47
8352025-0	1993	Effect on renin release of inhibiting renal nitric oxide synthesis in anaesthetized dogs.	Nitric Oxide	44-56	renin	Canis lupus familiaris	10-15
8352025-10	1993	In conclusion, inhibition of renal nitric oxide synthesis reduces basal renal blood flow and reduces renin release stimulated by renal arterial constriction.	Nitric Oxide	35-47	renin	Canis lupus familiaris	101-106
8352025-11	1993	These findings indicate that renal nitric oxide modulates both renal blood flow and renin release in vivo.	Nitric Oxide	35-47	renin	Canis lupus familiaris	84-89
8343235-1	1993	A-72517 is a potent inhibitor of human renin (IC50 = 1.0 nmol/L, pH 7.4 in plasma) and, aside from displaying modest activity against canine plasma renin (IC50 = 110 nmol/L), has been shown to be orally active in the dog and other animals.	zankiren hydrochloride	0-7	renin	Canis lupus familiaris	148-153
8495237-8	1993	GR117289 caused a reduction in plasma aldosterone levels (-35 +/- 16%) 45 min post-dose, despite increasing plasma renin activity (+ 173 +/- 42%).	GR 117289	0-8	renin	Canis lupus familiaris	115-120
8491504-3	1993	Under control conditions, infusion of norepinephrine (10-40 ng/min per milliliter per minute of control renal blood flow) increased plasma renin activity and decreased renal blood flow progressively by approximately 10-75%.	Norepinephrine	38-52	renin	Canis lupus familiaris	139-144
8515498-9	1993	The changes attributable to the pharmacological effect of RU44570 were a decreased activity of the angiotensin-converting enzyme, increases in plasma renin activity and urine volume, and decreases in specific gravity and concentrations of Na, K and Cl in the urine of every administration group.	trandolapril	58-65	renin	Canis lupus familiaris	150-155
7678671-0	1993	Effects of high doses of A-74273, a novel nonpeptidic and orally bioavailable renin inhibitor.	A 74273	25-32	renin	Canis lupus familiaris	78-83
7678671-3	1993	A-74273 represents a new class of potent and orally bioavailable nonpeptidic renin inhibitors.	A 74273	0-7	renin	Canis lupus familiaris	77-82
8423524-3	1993	Intrarenal arterial infusion of nifedipine (0.1 microgram/kg/min) or TMB-8 (50 and 100 micrograms/kg/min) increased basal urine flow rate, urinary sodium excretion rate and fractional excretion of sodium without affecting renal venous plasma norepinephrine concentration or plasma renin activity.	Nifedipine	32-42	renin	Canis lupus familiaris	281-286
8423524-3	1993	Intrarenal arterial infusion of nifedipine (0.1 microgram/kg/min) or TMB-8 (50 and 100 micrograms/kg/min) increased basal urine flow rate, urinary sodium excretion rate and fractional excretion of sodium without affecting renal venous plasma norepinephrine concentration or plasma renin activity.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	69-74	renin	Canis lupus familiaris	281-286
1335390-6	1992	Baseline plasma angiotensin II (42.5 +/- 11.8 pg/ml) and renin (64.5 +/- 92.7 mu-units/ml) concentrations were already elevated in response to salt depletion and rose significantly after Losartan infusion to reach a plateau by 70 min.	Salts	143-147	renin	Canis lupus familiaris	57-62
1335390-6	1992	Baseline plasma angiotensin II (42.5 +/- 11.8 pg/ml) and renin (64.5 +/- 92.7 mu-units/ml) concentrations were already elevated in response to salt depletion and rose significantly after Losartan infusion to reach a plateau by 70 min.	Losartan	187-195	renin	Canis lupus familiaris	57-62
1476271-9	1992	Prostaglandin E2 production increased in the stenotic kidney when the stenosis was more than 70%; aspirin inhibited prostaglandin synthesis and suppressed the stimulation of renin release.	Aspirin	98-105	renin	Canis lupus familiaris	174-179
1329565-10	1992	4) In both water-deprived and water-replete animals, saralasin and/or a V1-antagonist increased the renin response to hypotension, but a combined V1/V2-antagonist did not.	Water	30-35	renin	Canis lupus familiaris	100-105
1415735-6	1992	Despite the disparate hemodynamic responses, verapamil stimulated renal production of both renin and prostaglandin E2 in both groups of caval dogs.	Verapamil	45-54	renin	Canis lupus familiaris	91-96
1395108-0	1992	Intracoronary PGE2 and veratrine inhibits renin release in conscious dogs via chemosensitive ventricular afferents.	Dinoprostone	14-18	renin	Canis lupus familiaris	42-47
1336465-4	1992	Contractile responses to tetradecapeptide and ANG I were also reduced by KRI-1314, a renin inhibitor, and captopril, respectively.	KRI 1314	73-81	renin	Canis lupus familiaris	85-90
1395108-0	1992	Intracoronary PGE2 and veratrine inhibits renin release in conscious dogs via chemosensitive ventricular afferents.	Veratrine	23-32	renin	Canis lupus familiaris	42-47
1395108-4	1992	The present study in conscious instrumented dogs was carried out to determine the effects of intracoronary artery infusions of veratrine (Ver-IC) and PGE2 (PGE2-IC) on plasma renin activity (PRA).	Veratrine	127-136	renin	Canis lupus familiaris	175-180
1395108-4	1992	The present study in conscious instrumented dogs was carried out to determine the effects of intracoronary artery infusions of veratrine (Ver-IC) and PGE2 (PGE2-IC) on plasma renin activity (PRA).	Dinoprostone	150-154	renin	Canis lupus familiaris	175-180
1395108-4	1992	The present study in conscious instrumented dogs was carried out to determine the effects of intracoronary artery infusions of veratrine (Ver-IC) and PGE2 (PGE2-IC) on plasma renin activity (PRA).	Dinoprostone	156-160	renin	Canis lupus familiaris	175-180
1400063-1	1992	Increased activity of the renin-angiotensin system may be involved in sodium and water retention during controlled mechanical ventilation (CMV) with positive end-expiratory pressure (PEEP).	Sodium	70-76	renin	Canis lupus familiaris	26-31
1400063-1	1992	Increased activity of the renin-angiotensin system may be involved in sodium and water retention during controlled mechanical ventilation (CMV) with positive end-expiratory pressure (PEEP).	Water	81-86	renin	Canis lupus familiaris	26-31
1405342-1	1992	A method was developed to localize active renin in dog kidney sections using autoradiography to detect in vitro binding of the radiolabeled renin inhibitor, 125I-H77.	125i-h77	157-165	renin	Canis lupus familiaris	42-47
1405342-1	1992	A method was developed to localize active renin in dog kidney sections using autoradiography to detect in vitro binding of the radiolabeled renin inhibitor, 125I-H77.	125i-h77	157-165	renin	Canis lupus familiaris	140-145
1405342-2	1992	Light fixation by prior perfusion of the kidney with paraformaldehyde was used to immobilize renin without denaturing its binding activity.	paraform	53-69	renin	Canis lupus familiaris	93-98
1405342-8	1992	Competition for this 125I-H77 binding by a series of structurally different renin inhibitors showed a close correspondence between their reported inhibitory potency for renin and potency in the binding system.	125i-h77	21-29	renin	Canis lupus familiaris	76-81
1405342-8	1992	Competition for this 125I-H77 binding by a series of structurally different renin inhibitors showed a close correspondence between their reported inhibitory potency for renin and potency in the binding system.	125i-h77	21-29	renin	Canis lupus familiaris	169-174
1425946-2	1992	Intrarenal arterial infusion of semotiadil resulted in a significant increase in renal blood flow (RBF), glomerular filtration rate (GFR), urine flow, urinary excretion of electrolytes and renin release.	sesamodil	32-42	renin	Canis lupus familiaris	189-194
1425946-6	1992	In spite of the blockade of the intrarenal renin angiotensin system(RAS) with DuP753, semotiadil caused almost the same effects as it did in the absence of DuP753.	sesamodil	86-96	renin	Canis lupus familiaris	43-48
1317225-0	1992	Effect of captopril on the release of the components of the renin-angiotensin system into plasma and lymph.	Captopril	10-19	renin	Canis lupus familiaris	60-65
1356560-4	1992	ACE-inhibition, with enalapril (2 mg kg-1), caused a significant reduction in systemic arterial blood pressure (BP) with little or no effect on cardiac function, and a significant elevation of plasma renin activity (PRA).	Enalapril	21-30	renin	Canis lupus familiaris	200-205
1434110-6	1992	Intrarenal infusion of KB-2796 at 30 micrograms/kg/min and nicardipine at 0.3 microgram/kg/min produced a significant increase in GFR, RBF, UF, urinary excretion of electrolytes, and renin secretion rate.	lomerizine	23-30	renin	Canis lupus familiaris	183-188
1434110-6	1992	Intrarenal infusion of KB-2796 at 30 micrograms/kg/min and nicardipine at 0.3 microgram/kg/min produced a significant increase in GFR, RBF, UF, urinary excretion of electrolytes, and renin secretion rate.	Nicardipine	59-70	renin	Canis lupus familiaris	183-188
1315222-9	1992	Plasma renin activity, activated by the onset of pacing in the CHF group, was inhibited by the administration of intrarenal ouabain in this group only.	Ouabain	124-131	renin	Canis lupus familiaris	7-12
1316513-5	1992	The greatest increase in plasma renin activity and blood pressure occurred at week two which coincided with the greatest response to angiotensin-converting enzyme inhibition, when mean arterial blood pressure decreased more than 30 mmHg after administration of either captopril or enalapril (1 mg/kg, i.v.).	Captopril	268-277	renin	Canis lupus familiaris	32-37
1316513-5	1992	The greatest increase in plasma renin activity and blood pressure occurred at week two which coincided with the greatest response to angiotensin-converting enzyme inhibition, when mean arterial blood pressure decreased more than 30 mmHg after administration of either captopril or enalapril (1 mg/kg, i.v.).	Enalapril	281-290	renin	Canis lupus familiaris	32-37
1446972-6	1992	In the design of potent dog plasma renin inhibitors, the influence of the transition-state residue 4(S)-amino-3(S)-hydroxy-5-cyclohexylpentanoic acid (ACHPA)-commonly used as a substitute for the scissile-bond dipeptide to boost potency-is not obvious, and appears to be sequence dependent.	(s)-amino-3	100-111	renin	Canis lupus familiaris	35-40
1446972-6	1992	In the design of potent dog plasma renin inhibitors, the influence of the transition-state residue 4(S)-amino-3(S)-hydroxy-5-cyclohexylpentanoic acid (ACHPA)-commonly used as a substitute for the scissile-bond dipeptide to boost potency-is not obvious, and appears to be sequence dependent.	(s)-hydroxy-5-cyclohexylpentanoic acid	111-149	renin	Canis lupus familiaris	35-40
1446972-7	1992	The canine renin inhibitor Ac-paF-Pro-Phe-Val-statine-Leu-Phe-paF-NH2 (compound 15; IC50 of 1.7 nM against dog plasma renin at pH 7.4; statine, 4(S)-amino-3(S)-hydroxy-6-methylheptanoic acid; paF, para-aminophenylalanine) had a potent hypotensive effect when infused intravenously into conscious, sodium-depleted, normotensive dogs.	ac-paf-pro-phe-val-statine-leu-phe-paf-nh2	27-69	renin	Canis lupus familiaris	11-16
1446972-7	1992	The canine renin inhibitor Ac-paF-Pro-Phe-Val-statine-Leu-Phe-paF-NH2 (compound 15; IC50 of 1.7 nM against dog plasma renin at pH 7.4; statine, 4(S)-amino-3(S)-hydroxy-6-methylheptanoic acid; paF, para-aminophenylalanine) had a potent hypotensive effect when infused intravenously into conscious, sodium-depleted, normotensive dogs.	ac-paf-pro-phe-val-statine-leu-phe-paf-nh2	27-69	renin	Canis lupus familiaris	118-123
1446972-7	1992	The canine renin inhibitor Ac-paF-Pro-Phe-Val-statine-Leu-Phe-paF-NH2 (compound 15; IC50 of 1.7 nM against dog plasma renin at pH 7.4; statine, 4(S)-amino-3(S)-hydroxy-6-methylheptanoic acid; paF, para-aminophenylalanine) had a potent hypotensive effect when infused intravenously into conscious, sodium-depleted, normotensive dogs.	statine	46-53	renin	Canis lupus familiaris	11-16
1446972-7	1992	The canine renin inhibitor Ac-paF-Pro-Phe-Val-statine-Leu-Phe-paF-NH2 (compound 15; IC50 of 1.7 nM against dog plasma renin at pH 7.4; statine, 4(S)-amino-3(S)-hydroxy-6-methylheptanoic acid; paF, para-aminophenylalanine) had a potent hypotensive effect when infused intravenously into conscious, sodium-depleted, normotensive dogs.	statine	46-53	renin	Canis lupus familiaris	118-123
1446972-7	1992	The canine renin inhibitor Ac-paF-Pro-Phe-Val-statine-Leu-Phe-paF-NH2 (compound 15; IC50 of 1.7 nM against dog plasma renin at pH 7.4; statine, 4(S)-amino-3(S)-hydroxy-6-methylheptanoic acid; paF, para-aminophenylalanine) had a potent hypotensive effect when infused intravenously into conscious, sodium-depleted, normotensive dogs.	Platelet Activating Factor	30-33	renin	Canis lupus familiaris	11-16
1504821-6	1992	Plasma renin activity increased 2 and 4 weeks after MPTP treatment.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	52-56	renin	Canis lupus familiaris	7-12
1608150-1	1992	Plasma levels of catecholamines, aldosterone and cortisol as well as plasma renin activity during hypotension by ketanserin were studied in 9 mongrel dogs under 0.87% halothane in oxygen (1MAC).	Ketanserin	113-123	renin	Canis lupus familiaris	76-81
1310218-1	1992	The present experiments were designed to determine whether blockade of endogenous opiate receptors with naloxone would suppress renin release induced by circulating epinephrine or by reductions of renal perfusion pressure.	Naloxone	104-112	renin	Canis lupus familiaris	128-133
1317225-1	1992	UNLABELLED: The effects of captopril on the intrarenal renin-angiotensin system were assessed from measurements in arterial plasma, renal venous plasma, and renal lymph from salt-depleted dogs.	Captopril	27-36	renin	Canis lupus familiaris	55-60
1317225-5	1992	Although captopril increased the secretion of active renin into renal venous plasma by six-fold, the secretion of total renin was unchanged because of a reciprocal fall in the secretion of inactive renin.	Captopril	9-18	renin	Canis lupus familiaris	53-58
1317225-7	1992	IN CONCLUSION: (1) all components of the renin-angiotensin system are represented in the renal interstitium, as reflected in lymph; (2) Ang II concentrations in renal lymph in vivo approximate arterial levels; (3) increased secretion of active renin into plasma during intrarenal infusion of captopril into denervated kidneys is due predominantly to renin activation; and (4) renal vascular resistance may depend on the concentration of Ang II in the renal interstitium.	Captopril	292-301	renin	Canis lupus familiaris	41-46
1750573-6	1991	Furthermore, when RAP was reduced (approximately 25 mmHg) as a result of chronically blocking the renin-angiotensin system with captopril, the renal responses to the high rate of NE infusion were exaggerated even further; in four of five dogs, total renal ischemia occurred in response to NE.	Captopril	128-137	renin	Canis lupus familiaris	98-103
1760542-10	1991	These data provide further evidence that endogenous adenosine contributes substantially to the control of renin release but only modestly to the control of RBF and GFR and to renal autoregulatory capability.	Adenosine	52-61	renin	Canis lupus familiaris	106-111
1760542-11	1991	The natriuretic responses during adenosine blockade, which occurred in the face of elevated renin levels, support the hypothesis that endogenous adenosine enhances tubular sodium reabsorption rate.	Adenosine	33-42	renin	Canis lupus familiaris	92-97
1760542-11	1991	The natriuretic responses during adenosine blockade, which occurred in the face of elevated renin levels, support the hypothesis that endogenous adenosine enhances tubular sodium reabsorption rate.	Adenosine	145-154	renin	Canis lupus familiaris	92-97
1864303-2	1991	In the normal kidney (N = 5), intrarenal infusion of porcine BNP-(1-26) (pBNP) at a dose of 50 ng/kg per min attenuated the renin secretion rate significantly to 9 +/- 27% of control without exerting a significant effect on mean arterial pressure (MAP), renal blood flow (RBF) or glomerular filtration rate (GFR); urine flow (V) was significantly increased to 260 +/- 33% of control and urinary excretion of sodium (UNaV) to 480 +/- 140% of control.	pbnp	73-77	renin	Canis lupus familiaris	124-129
1864303-4	1991	The renin secretion rate was attenuated by hypertonic saline infusion (1 mEq NaCl/min) to 87 +/- 31% of control.	Sodium Chloride	77-81	renin	Canis lupus familiaris	4-9
1864303-5	1991	In another group (N = 6), administration of pBNP at a dose of 50 ng/kg per min during hypertonic saline infusion (1 mEq NaCl/min) increased the renin secretion rate to 196 +/- 57%, increased RBF to 160 +/- 13%, increased GFR to 137 +/- 22%, increased V to 221 +/- 29%, and increased UNaV to 218 +/- 29% of the values measured during hypertonic saline infusion.	pbnp	44-48	renin	Canis lupus familiaris	144-149
1905236-0	1991	Serotonin-induced renin release in the dog kidney.	Serotonin	0-9	renin	Canis lupus familiaris	18-23
1999358-8	1991	These findings indicate that the renin-angiotensin system prevents exaggerated renal vascular responses to chronic norepinephrine stimulation by preserving renal perfusion pressure.	Norepinephrine	115-129	renin	Canis lupus familiaris	33-38
1905236-1	1991	The effect of serotonin (5-HT) on renin release was examined in denervated kidney of the pentobarbital-anesthetized dog.	Serotonin	14-23	renin	Canis lupus familiaris	34-39
1905236-4	1991	The renin release induced by 5-HT was suppressed during intrarenal arterial infusion of a 5-HT1 and 5-HT2 antagonist, methysergide (30 micrograms/kg per min), or a selective 5-HT2 antagonist, ketanserin (3 micrograms/kg per min).	Methysergide	118-130	renin	Canis lupus familiaris	4-9
1905236-4	1991	The renin release induced by 5-HT was suppressed during intrarenal arterial infusion of a 5-HT1 and 5-HT2 antagonist, methysergide (30 micrograms/kg per min), or a selective 5-HT2 antagonist, ketanserin (3 micrograms/kg per min).	Ketanserin	192-202	renin	Canis lupus familiaris	4-9
1905236-7	1991	These results suggest that stimulation of renal 5-HT receptors, probably of the 5-HT2 type, can induce renin release from the dog kidney, which may be dependent on renal prostaglandin production.	Prostaglandins	170-183	renin	Canis lupus familiaris	103-108
1988669-2	1991	In the rat and dog, exogenous adenosine inhibits renin release and adenosine receptor blockade augments stimulated renin release, suggesting that endogenous adenosine contributes to the regulation of renin release.	Adenosine	67-76	renin	Canis lupus familiaris	115-120
1846840-7	1991	Administration of MK-422 led to the disappearance of circulating angiotensin II and its fragments both before and after a second injection of the same dose of renin.	Enalaprilat	18-24	renin	Canis lupus familiaris	159-164
1864303-5	1991	In another group (N = 6), administration of pBNP at a dose of 50 ng/kg per min during hypertonic saline infusion (1 mEq NaCl/min) increased the renin secretion rate to 196 +/- 57%, increased RBF to 160 +/- 13%, increased GFR to 137 +/- 22%, increased V to 221 +/- 29%, and increased UNaV to 218 +/- 29% of the values measured during hypertonic saline infusion.	Sodium Chloride	120-124	renin	Canis lupus familiaris	144-149
1864303-6	1991	Our results indicate that BNP inhibits renin secretion through sodium delivery to the macula densa and effectively inhibits the tubuloglomerular feedback response that is activated by intrarenal hypertonic saline infusion.	Sodium	63-69	renin	Canis lupus familiaris	39-44
1986185-2	1991	Renin granules were isolated from the dog kidney cortex by discontinuous sucrose density gradient centrifugation.	Sucrose	73-80	renin	Canis lupus familiaris	0-5
1972413-2	1990	Intracerebroventricular (ICV) injections of 0.2 ml of 1.5 M NaCl increased mean arterial blood pressure (+29.7 +/- 3.0 mmHg, mean +/- SE), heart rate (+27.9 +/- 7.0 beats/min), plasma concentrations of vasopressin (+48.9 +/- 8.2 pg/ml), norepinephrine (+40.0 +/- 6.2 pg/ml), epinephrine (+231.4 +/- 21.4 pg/ml) and cortisol (+5.3 +/- 1.1 micrograms/dl) and decreased plasma renin activity (-2.0 +/- 0.4 ng/ml/hr).	Sodium Chloride	60-64	renin	Canis lupus familiaris	374-379
1988669-2	1991	In the rat and dog, exogenous adenosine inhibits renin release and adenosine receptor blockade augments stimulated renin release, suggesting that endogenous adenosine contributes to the regulation of renin release.	Adenosine	30-39	renin	Canis lupus familiaris	49-54
1988669-2	1991	In the rat and dog, exogenous adenosine inhibits renin release and adenosine receptor blockade augments stimulated renin release, suggesting that endogenous adenosine contributes to the regulation of renin release.	Adenosine	67-76	renin	Canis lupus familiaris	115-120
2210812-5	1990	Acute administration of captopril caused significantly greater changes in arterial pressure and peripheral conductance throughout the period of stenosis than before stenosis (and greater than in sham-stenosis dogs), indicating that angiotensin II was constricting the peripheral vasculature even when plasma renin levels were no longer elevated.	Captopril	24-33	renin	Canis lupus familiaris	308-313
2148906-3	1990	In the present studies in awake dogs, intravenous infusion of low doses (6.3-50 pmol.kg-1.min-1) of iso-rANP(1-45) and iso-rANP(17-45) increased plasma immunoreactive ANP and suppressed plasma renin activity (PRA) and aldosterone.	iso-ranp	100-108	renin	Canis lupus familiaris	193-198
2148906-3	1990	In the present studies in awake dogs, intravenous infusion of low doses (6.3-50 pmol.kg-1.min-1) of iso-rANP(1-45) and iso-rANP(17-45) increased plasma immunoreactive ANP and suppressed plasma renin activity (PRA) and aldosterone.	iso-ranp	119-127	renin	Canis lupus familiaris	193-198
2222949-2	1990	Doses of 0.2, 0.5, and 1.0 mg/kg captopril reduced mean arterial pressure by 33 +/- 4, 31 +/- 7, and 51 +/- 4 mm Hg and increased plasma renin activity by 40.1 +/- 9.8, 57.6 +/- 3.2, and 34.4 +/- 15.2 ng A1/mL/h, respectively.	Captopril	33-42	renin	Canis lupus familiaris	137-142
2141305-0	1990	Effects of atrial natriuretic peptide on phenylephrine-induced renin release in dogs.	Phenylephrine	41-54	renin	Canis lupus familiaris	63-68
2141305-4	1990	Phenylephrine (50 ng/kg per min) infused into the renal artery increased the renal secretion rate of renin (RSR) without affecting systemic blood pressure or renal blood flow.	Phenylephrine	0-13	renin	Canis lupus familiaris	101-106
2141305-8	1990	The results suggests that exogenously administered ANP could suppress alpha-adrenoceptor-mediated renin release in the dog.	Atrial Natriuretic Factor	51-54	renin	Canis lupus familiaris	98-103
2184671-0	1990	Regulation of renin release and renal hemodynamics during acute and chronic verapamil administration.	Verapamil	76-85	renin	Canis lupus familiaris	14-19
2184671-1	1990	The effects of short- and long-term administration of the calcium-entry blocker verapamil on regulation of renal hemodynamics and renin release were analyzed in anesthetized dogs at controlled levels of renal perfusion pressure between 110 and 60 mmHg.	Verapamil	80-89	renin	Canis lupus familiaris	130-135
2184671-8	1990	Verapamil profoundly alters regulation of renal hemodynamics and renin release and the effect is prominent during both short- and long-term administration.	Verapamil	0-9	renin	Canis lupus familiaris	65-70
2160492-1	1990	The aim of this study was to determine whether the renin inhibitor CP-71362 (Pfizer Central Research, Groton, Connecticut, USA) is capable of inducing sustained reductions in arterial pressure in sodium-depleted dogs and to examine the changes in renal function associated with chronic renin inhibition.	CP 71362	67-75	renin	Canis lupus familiaris	51-56
2160492-1	1990	The aim of this study was to determine whether the renin inhibitor CP-71362 (Pfizer Central Research, Groton, Connecticut, USA) is capable of inducing sustained reductions in arterial pressure in sodium-depleted dogs and to examine the changes in renal function associated with chronic renin inhibition.	CP 71362	67-75	renin	Canis lupus familiaris	286-291
2160492-1	1990	The aim of this study was to determine whether the renin inhibitor CP-71362 (Pfizer Central Research, Groton, Connecticut, USA) is capable of inducing sustained reductions in arterial pressure in sodium-depleted dogs and to examine the changes in renal function associated with chronic renin inhibition.	Sodium	196-202	renin	Canis lupus familiaris	51-56
2160492-4	1990	Plasma renin activity was suppressed to undetectable levels throughout the 7 days of CP-71362 infusion.	CP 71362	85-93	renin	Canis lupus familiaris	7-12
2114660-0	1990	Acute changes in osmolality and renin and respiratory control of arterial PCO2 and [H+].	pco2	74-78	renin	Canis lupus familiaris	32-37
2114660-7	1990	Ventilatory control of PaCO2 during acute lowering of osmolality may be related to a central inter-action between osmolality and the renin-angiotensin system.	paco2	23-28	renin	Canis lupus familiaris	133-138
1830909-1	1991	In 1984 we demonstrated in an animal model of chronic congestive heart failure due to rapid right ventricular pacing in chronically instrumented dogs, that the inhibition of the renin-angiotensin-aldosterone system by captopril from the onset of pacing has beneficial effects on hemodynamic and neurohumoral mechanisms.	Captopril	218-227	renin	Canis lupus familiaris	178-183
2404854-7	1990	Myocardial ischemia in benazeprilat-treated dogs increased plasma renin activity and circulating levels of angiotensin I.	benazeprilat	23-35	renin	Canis lupus familiaris	66-71
2107658-0	1990	Stimulation of renin release by PGE2 and PGI2 infusion in the dog: enhancing effect of ureteral occlusion or administration of ethacrynic acid.	Dinoprostone	32-36	renin	Canis lupus familiaris	15-20
2107658-0	1990	Stimulation of renin release by PGE2 and PGI2 infusion in the dog: enhancing effect of ureteral occlusion or administration of ethacrynic acid.	Epoprostenol	41-45	renin	Canis lupus familiaris	15-20
2107658-2	1990	The first was to compare the potencies of PGE2 and PGI2 as stimulators of renin release and demonstrate their dependency on activation of intrarenal mechanisms for renin release.	Dinoprostone	42-46	renin	Canis lupus familiaris	74-79
2107658-2	1990	The first was to compare the potencies of PGE2 and PGI2 as stimulators of renin release and demonstrate their dependency on activation of intrarenal mechanisms for renin release.	Epoprostenol	51-55	renin	Canis lupus familiaris	74-79
2107658-3	1990	The second objective was to demonstrate that ethacrynic acid (ECA) increases renin release not as a stimulator, but by activating intrarenal mechanisms.	Ethacrynic Acid	45-60	renin	Canis lupus familiaris	77-82
2107658-3	1990	The second objective was to demonstrate that ethacrynic acid (ECA) increases renin release not as a stimulator, but by activating intrarenal mechanisms.	Ethacrynic Acid	62-65	renin	Canis lupus familiaris	77-82
2107658-4	1990	After inhibiting renal prostaglandin synthesis by indomethacin, PGE2 and PGI2 infused into the aorta proximal to the renal arteries exerted no significant effects on renin release, but increased renin release during ureteral occlusion.	Dinoprostone	64-68	renin	Canis lupus familiaris	195-200
2107658-4	1990	After inhibiting renal prostaglandin synthesis by indomethacin, PGE2 and PGI2 infused into the aorta proximal to the renal arteries exerted no significant effects on renin release, but increased renin release during ureteral occlusion.	Epoprostenol	73-77	renin	Canis lupus familiaris	195-200
2107658-5	1990	At equimolar infusion rates, PGI2 increased renin release twice as much as PGE2, but this difference in potency may reflect differences in degradation since 86% of PGE2 and 29% of PGI2 (measured as 6-keto-PGF1 alpha) were degraded during one passage through the kidney.	Epoprostenol	29-33	renin	Canis lupus familiaris	44-49
2107658-6	1990	By infusing PGF2 at 8 nmol min-1 and PGI2 at 2 nmol min-1 renin release increased equally and the prostaglandin outputs increased to the same levels as during ureteral occlusion before indomethacin administration.	Epoprostenol	37-41	renin	Canis lupus familiaris	58-63
2107658-8	1990	However, infusion of PGE2 during continuous ECA administration increased renin release in a dose-dependent manner similar to the experiments performed during ureteral occlusion.	Dinoprostone	21-25	renin	Canis lupus familiaris	73-78
2107658-9	1990	We conclude that PGI2 and PGE2 in the amounts synthesized in the kidney seem to be equally important stimulators of renin release but their relative potencies cannot be determined because the site of degradation is uncertain.	Epoprostenol	17-21	renin	Canis lupus familiaris	116-121
2107658-9	1990	We conclude that PGI2 and PGE2 in the amounts synthesized in the kidney seem to be equally important stimulators of renin release but their relative potencies cannot be determined because the site of degradation is uncertain.	Dinoprostone	26-30	renin	Canis lupus familiaris	116-121
2107658-10	1990	Renin release is enhanced by intrarenal mechanisms activated by ECA infusion or ureteral occlusion, which both cause autoregulatory vasodilation and reduce NaCl reabsorption at the macula densa.	Sodium Chloride	156-160	renin	Canis lupus familiaris	0-5
2404858-0	1990	Stimulation of renin release by intrarenal calcium infusion.	Calcium	43-50	renin	Canis lupus familiaris	15-20
2404858-1	1990	The effects of intrarenal infusions of calcium gluconate (10 and 100 micrograms Ca/kg/min) on renin secretion were studied in anesthetized mongrel dogs.	Calcium Gluconate	39-56	renin	Canis lupus familiaris	94-99
2404858-10	1990	It is concluded that 1) the intrarenal infusion of small doses of calcium gluconate is capable of stimulating renin secretion through a prostaglandin-mediated mechanism, and 2) the stimulation of renin secretion as well as the increase in sodium excretion induced by calcium are independent of hemodynamic alterations.	Calcium Gluconate	66-83	renin	Canis lupus familiaris	110-115
2404858-10	1990	It is concluded that 1) the intrarenal infusion of small doses of calcium gluconate is capable of stimulating renin secretion through a prostaglandin-mediated mechanism, and 2) the stimulation of renin secretion as well as the increase in sodium excretion induced by calcium are independent of hemodynamic alterations.	Calcium	66-73	renin	Canis lupus familiaris	110-115
2404858-10	1990	It is concluded that 1) the intrarenal infusion of small doses of calcium gluconate is capable of stimulating renin secretion through a prostaglandin-mediated mechanism, and 2) the stimulation of renin secretion as well as the increase in sodium excretion induced by calcium are independent of hemodynamic alterations.	Calcium	66-73	renin	Canis lupus familiaris	196-201
2137250-7	1990	The increase in plasma vasopressin induced by hemorrhage was potentiated, but the increase in plasma renin activity was attenuated when alpha-hANP was infused.	NPPA protein, human	136-146	renin	Canis lupus familiaris	101-106
2137250-9	1990	Intravenous administration of alpha-hANP modulates the hemodynamic responses elicited by hemorrhage, potentiates the rise in plasma vasopressin, and attenuates the rise in plasma renin activity induced by acute blood loss in conscious dogs.	NPPA protein, human	30-40	renin	Canis lupus familiaris	179-184
33942401-0	2021	Erratum for "Role of electrolyte concentrations and renin-angiotensin-aldosterone activation in the staging of canine heart disease".	Aldosterone	70-81	renin	Canis lupus familiaris	52-57
33814522-1	2021	Renin and neuronal nitric oxide synthase in the kidney control the renin-angiotensin and tubuloglomerular feedback systems.	Nitric Oxide	19-31	renin	Canis lupus familiaris	67-72
2512401-3	1989	Oral administration of ES-6864 at 30 mg/kg to conscious, sodium-depleted marmosets produced a significant blood pressure reduction and a significant inhibition of plasma renin activity, which persisted for 6 hours.	ES 6864	23-30	renin	Canis lupus familiaris	170-175
2571299-2	1989	Electrical stimulation of the renal nerves (RNS, 1 Hz) increased the renal secretion rate of renin (RSR) by 627 +/- 141 ng angiotensin I (ANG I)/min and that of norepinephrine (NESR) by 22.2 +/- 5.9 ng/min.	Reactive Nitrogen Species	44-47	renin	Canis lupus familiaris	93-98
2676058-8	1989	Since pinacidil induced an increase in plasma catecholamines, free fatty acids, glucose, plasma renin activity and aldosterone in SAD dogs it is suggested that this sympathetic activation is independent of the baroreceptor reflex pathways.	Pinacidil	6-15	renin	Canis lupus familiaris	96-101
2681964-3	1989	Moderate activations of the renal sympathetic nerves, which do not change renal blood flow 1) decrease sodium excretion independent of changes in angiotensin II, 2) interact with the pressure-dependent mechanism of renin release by resetting its threshold pressure and 3) modulate autoregulation by increasing the lower limits of glomerular filtration rate and renal blood flow-autoregulation.	Sodium	103-109	renin	Canis lupus familiaris	215-220
2512401-3	1989	Oral administration of ES-6864 at 30 mg/kg to conscious, sodium-depleted marmosets produced a significant blood pressure reduction and a significant inhibition of plasma renin activity, which persisted for 6 hours.	Sodium	57-63	renin	Canis lupus familiaris	170-175
2512401-5	1989	Oral administration of ES-6864 to hog renin-infused rats produced dose-related decreases in blood pressure.	ES 6864	23-30	renin	Canis lupus familiaris	38-43
2546456-3	1989	Propranolol was used to block neural stimulation of renin release.	Propranolol	0-11	renin	Canis lupus familiaris	52-57
2546456-6	1989	The combined infusion of ANF and propranolol produced an additive and complete inhibition of the renin response to TIVCC; therefore the effect of ANF is independent of neural stimulation of renin release.	Propranolol	33-44	renin	Canis lupus familiaris	97-102
2737715-1	1989	Studies in Lichstein"s laboratory suggest that the endogenous digitalislike substance implicated in low renin hypertension might be a steroidal dienolide derivative.	dienolide	144-153	renin	Canis lupus familiaris	104-109
2665522-5	1989	On another day in the same animals, the activity of the renin-angiotensin system was fixed by infusing captopril and sufficient angiotensin II to restore arterial pressure to normal (2-5 ng.kg-1.min-1 iv).	Captopril	103-112	renin	Canis lupus familiaris	56-61
2544099-0	1989	Adrenergic control of renin during dietary sodium deprivation in conscious dogs.	Sodium	43-49	renin	Canis lupus familiaris	22-27
2570368-0	1989	Methylxanthines augment the renin response to suprarenal-aortic constriction.	methylxanthine	0-15	renin	Canis lupus familiaris	28-33
2570368-1	1989	In a previous study we discovered that the adenosine receptor antagonist, caffeine, increases plasma renin activity and blood pressure in renin-dependent renovascular hypertension.	Caffeine	74-82	renin	Canis lupus familiaris	101-106
2570368-1	1989	In a previous study we discovered that the adenosine receptor antagonist, caffeine, increases plasma renin activity and blood pressure in renin-dependent renovascular hypertension.	Caffeine	74-82	renin	Canis lupus familiaris	138-143
2570368-2	1989	The purpose of the present investigation was to determine whether methylxanthines augment the increase in renin secretion induced by a reduction in renal perfusion pressure and, if so, whether this effect is mediated by a direct action on juxtaglomerular cells.	methylxanthine	66-81	renin	Canis lupus familiaris	106-111
2570368-3	1989	Accordingly, we examined the effects of infusions of caffeine and theophylline directly into the renal artery on the increase in renin secretion induced by suprarenal aortic constriction.	Caffeine	53-61	renin	Canis lupus familiaris	129-134
2570368-3	1989	Accordingly, we examined the effects of infusions of caffeine and theophylline directly into the renal artery on the increase in renin secretion induced by suprarenal aortic constriction.	Theophylline	66-78	renin	Canis lupus familiaris	129-134
2570368-4	1989	All studies were conducted in dogs receiving an intravenous infusion of propranolol to prevent changes in renin secretion mediated indirectly via the sympathetic nervous system.	Propranolol	72-83	renin	Canis lupus familiaris	106-111
2570368-5	1989	Caffeine (5 mg/min) increased the renin response to suprarenal aortic constriction about 10-fold without significantly affecting renal hemodynamics or excretory function.	Caffeine	0-8	renin	Canis lupus familiaris	34-39
2570368-7	1989	However, in the non-filtering, beta-adrenoceptor blocked, canine kidney, theophylline markedly increased the renin response to suprarenal aortic constriction.	Theophylline	73-85	renin	Canis lupus familiaris	109-114
2570368-8	1989	These results indicate that methylxanthines can potentiate the renin response to a reduction in renal perfusion pressure most likely by directly affecting the juxtaglomerular cells; however, since increased sodium delivery to the macula densa inhibits renin release, the extent to which methylxanthines affect the renin response to renal artery hypotension depends on how vigorous the diuretic response is to a given methylxanthine.	methylxanthine	28-43	renin	Canis lupus familiaris	63-68
2570368-8	1989	These results indicate that methylxanthines can potentiate the renin response to a reduction in renal perfusion pressure most likely by directly affecting the juxtaglomerular cells; however, since increased sodium delivery to the macula densa inhibits renin release, the extent to which methylxanthines affect the renin response to renal artery hypotension depends on how vigorous the diuretic response is to a given methylxanthine.	Sodium	207-213	renin	Canis lupus familiaris	252-257
2570368-8	1989	These results indicate that methylxanthines can potentiate the renin response to a reduction in renal perfusion pressure most likely by directly affecting the juxtaglomerular cells; however, since increased sodium delivery to the macula densa inhibits renin release, the extent to which methylxanthines affect the renin response to renal artery hypotension depends on how vigorous the diuretic response is to a given methylxanthine.	Sodium	207-213	renin	Canis lupus familiaris	252-257
2570368-8	1989	These results indicate that methylxanthines can potentiate the renin response to a reduction in renal perfusion pressure most likely by directly affecting the juxtaglomerular cells; however, since increased sodium delivery to the macula densa inhibits renin release, the extent to which methylxanthines affect the renin response to renal artery hypotension depends on how vigorous the diuretic response is to a given methylxanthine.	methylxanthine	287-302	renin	Canis lupus familiaris	63-68
2570368-8	1989	These results indicate that methylxanthines can potentiate the renin response to a reduction in renal perfusion pressure most likely by directly affecting the juxtaglomerular cells; however, since increased sodium delivery to the macula densa inhibits renin release, the extent to which methylxanthines affect the renin response to renal artery hypotension depends on how vigorous the diuretic response is to a given methylxanthine.	methylxanthine	28-42	renin	Canis lupus familiaris	63-68
2570368-8	1989	These results indicate that methylxanthines can potentiate the renin response to a reduction in renal perfusion pressure most likely by directly affecting the juxtaglomerular cells; however, since increased sodium delivery to the macula densa inhibits renin release, the extent to which methylxanthines affect the renin response to renal artery hypotension depends on how vigorous the diuretic response is to a given methylxanthine.	methylxanthine	28-42	renin	Canis lupus familiaris	252-257
2570368-8	1989	These results indicate that methylxanthines can potentiate the renin response to a reduction in renal perfusion pressure most likely by directly affecting the juxtaglomerular cells; however, since increased sodium delivery to the macula densa inhibits renin release, the extent to which methylxanthines affect the renin response to renal artery hypotension depends on how vigorous the diuretic response is to a given methylxanthine.	methylxanthine	28-42	renin	Canis lupus familiaris	252-257
2566282-6	1989	The higher plasma atriopeptin concentration observed during exercise under beta-blockade may contribute to the reduction of the response of plasma renin activity (1.0 +/- 0.1 vs. 3.0 +/- 0.6 ng.ml-1.h-1) and aldosterone concentration (87 +/- 36 vs. 138 +/- 25 pg/ml).	Aldosterone	208-219	renin	Canis lupus familiaris	147-152
2682268-0	1989	Interaction of cyclosporine-A with the renin-angiotensin system in canine veins.	Cyclosporine	15-29	renin	Canis lupus familiaris	39-44
2682268-5	1989	infusion of the renin inhibitor H-77 (0.1 mg/kg/h) reversed the inhibition of bradykinin by both clopamide and cyclosporine-A.	H 77	32-36	renin	Canis lupus familiaris	16-21
2682268-5	1989	infusion of the renin inhibitor H-77 (0.1 mg/kg/h) reversed the inhibition of bradykinin by both clopamide and cyclosporine-A.	Clopamide	97-106	renin	Canis lupus familiaris	16-21
2682268-5	1989	infusion of the renin inhibitor H-77 (0.1 mg/kg/h) reversed the inhibition of bradykinin by both clopamide and cyclosporine-A.	Cyclosporine	111-125	renin	Canis lupus familiaris	16-21
2566282-7	1989	Vasopressin concentration was lower at rest and during exercise under propranolol (3.5 +/- 1.3 vs. 4.9 +/- 0.9 and 6.1 +/- 2.2 vs. 9.9 +/- 1.5 pg/ml, respectively), which might reflect a dissociation between activity of the renin-angiotensin system and vasopressin release.	Propranolol	70-81	renin	Canis lupus familiaris	224-229
2472522-13	1989	In conclusion, the release of renin by fenoldopam is responsible for the development of tolerance to the hypotensive effects of fenoldopam.	Fenoldopam	128-138	renin	Canis lupus familiaris	30-35
2570363-0	1989	Adenosine inhibits renin release induced by suprarenal-aortic constriction and prostacyclin.	Adenosine	0-9	renin	Canis lupus familiaris	19-24
2570363-0	1989	Adenosine inhibits renin release induced by suprarenal-aortic constriction and prostacyclin.	Epoprostenol	79-91	renin	Canis lupus familiaris	19-24
2570363-1	1989	The purpose of this study was to determine whether adenosine can attenuate the renin release response to a reduction in renal perfusion pressure.	Adenosine	51-60	renin	Canis lupus familiaris	79-84
2570363-5	1989	However, during the intrarenal infusions of adenosine, renin secretion rate did not increase significantly.	Adenosine	44-53	renin	Canis lupus familiaris	55-60
2570363-6	1989	Analysis of variance indicated that both doses of adenosine reduced the renin response to renal artery hypotension.	Adenosine	50-59	renin	Canis lupus familiaris	72-77
2570363-8	1989	Adenosine also significantly attenuated the renin release response to PGI2.	Adenosine	0-9	renin	Canis lupus familiaris	44-49
2570363-8	1989	Adenosine also significantly attenuated the renin release response to PGI2.	Epoprostenol	70-74	renin	Canis lupus familiaris	44-49
2570363-9	1989	We conclude that adenosine can inhibit the renin release response to both renal artery hypotension and PGI2 and that this effect is most likely mediated by a direct action of adenosine on juxtaglomerular cells.	Adenosine	17-26	renin	Canis lupus familiaris	43-48
2570363-9	1989	We conclude that adenosine can inhibit the renin release response to both renal artery hypotension and PGI2 and that this effect is most likely mediated by a direct action of adenosine on juxtaglomerular cells.	Epoprostenol	103-107	renin	Canis lupus familiaris	43-48
2570363-9	1989	We conclude that adenosine can inhibit the renin release response to both renal artery hypotension and PGI2 and that this effect is most likely mediated by a direct action of adenosine on juxtaglomerular cells.	Adenosine	175-184	renin	Canis lupus familiaris	43-48
2570363-10	1989	Also, since PGI2 may be a mediator of the renin response to renal artery hypotension, the data are consistent with the hypothesis that adenosine inhibits the renin response to renal artery hypotension by attenuating the response of juxtaglomerular cells to PGI2.	Epoprostenol	12-16	renin	Canis lupus familiaris	42-47
2570363-10	1989	Also, since PGI2 may be a mediator of the renin response to renal artery hypotension, the data are consistent with the hypothesis that adenosine inhibits the renin response to renal artery hypotension by attenuating the response of juxtaglomerular cells to PGI2.	Epoprostenol	12-16	renin	Canis lupus familiaris	158-163
2570363-10	1989	Also, since PGI2 may be a mediator of the renin response to renal artery hypotension, the data are consistent with the hypothesis that adenosine inhibits the renin response to renal artery hypotension by attenuating the response of juxtaglomerular cells to PGI2.	Adenosine	135-144	renin	Canis lupus familiaris	42-47
2570363-10	1989	Also, since PGI2 may be a mediator of the renin response to renal artery hypotension, the data are consistent with the hypothesis that adenosine inhibits the renin response to renal artery hypotension by attenuating the response of juxtaglomerular cells to PGI2.	Adenosine	135-144	renin	Canis lupus familiaris	158-163
2570363-10	1989	Also, since PGI2 may be a mediator of the renin response to renal artery hypotension, the data are consistent with the hypothesis that adenosine inhibits the renin response to renal artery hypotension by attenuating the response of juxtaglomerular cells to PGI2.	Epoprostenol	257-261	renin	Canis lupus familiaris	158-163
2523199-8	1989	The additional blockade of the renin-angiotensin system by captopril showed mainly a vasodilator effect on peripheral arterial resistance vessels, resulting in an increase of cardiac output.	Captopril	59-68	renin	Canis lupus familiaris	31-36
2666610-1	1989	The effect of renin inhibitor ES-1005 on renin gene expression was investigated in sodium-depleted marmosets.	ES 1005	30-37	renin	Canis lupus familiaris	41-46
2666610-5	1989	We also investigated the inhibitory potency of the renin inhibitor ES-6864 on the renin-like activity in dog tissues (adrenal glands, aorta and brainstem).	ES 6864	67-74	renin	Canis lupus familiaris	51-56
2666614-2	1989	A 3-day infusion of the renin inhibitor isovaleryl -His-Pro-Phe-His-Sta-Leu-Phe-NH2 (SCRIP) lowered MAP to an average of 79 +/- 4 mmHg.	isovaleryl -his	40-55	renin	Canis lupus familiaris	24-29
2666614-2	1989	A 3-day infusion of the renin inhibitor isovaleryl -His-Pro-Phe-His-Sta-Leu-Phe-NH2 (SCRIP) lowered MAP to an average of 79 +/- 4 mmHg.	Pro-Phe-His	56-67	renin	Canis lupus familiaris	24-29
2666614-2	1989	A 3-day infusion of the renin inhibitor isovaleryl -His-Pro-Phe-His-Sta-Leu-Phe-NH2 (SCRIP) lowered MAP to an average of 79 +/- 4 mmHg.	sta-leu-phe-nh2	68-83	renin	Canis lupus familiaris	24-29
2472522-0	1989	Increase in plasma renin activity evoked by fenoldopam in dogs is directly mediated by dopamine1 receptor stimulation.	Fenoldopam	44-54	renin	Canis lupus familiaris	19-24
2472522-2	1989	infusion of fenoldopam (2.0 micrograms/kg/min) produced a decrease in mean aortic blood pressure (MAP) and an increase in renal blood flow (RBF) and plasma renin activity (PRA).	Fenoldopam	12-22	renin	Canis lupus familiaris	156-161
2472522-13	1989	In conclusion, the release of renin by fenoldopam is responsible for the development of tolerance to the hypotensive effects of fenoldopam.	Fenoldopam	39-49	renin	Canis lupus familiaris	30-35
2545579-9	1989	MK-0521 inhibited the serum ACE activity and increased the plasma renin activity, while it had a tendency to decrease plasma aldosterone level.	mk-0521	0-7	renin	Canis lupus familiaris	66-71
2545580-5	1989	MK-0521 was more inhibitory on the renin-angiotensin system than captopril.	mk-0521	0-7	renin	Canis lupus familiaris	35-40
2545580-6	1989	In the acute stage of hypertension, the dogs treated with MK-0521 had increased angiotensin converting enzyme (ACE) activity, while they had decreased plasma angiotensin II level and elevated plasma angiotensin I level and plasma renin activity.	mk-0521	58-65	renin	Canis lupus familiaris	230-235
2664751-6	1989	Moreover, cadralazine increased plasma renin activity to a lesser extent than hydralazine, and this could explain the different effect on water and sodium excretion after acute administration of the two drugs.	cadralazine	10-21	renin	Canis lupus familiaris	39-44
2644850-4	1989	Sympathetic neural control of renin release was reversibly blocked with propranolol.	Propranolol	72-83	renin	Canis lupus familiaris	30-35
2536643-6	1989	Efficacy of MK421 was documented by 83% inhibition of the pressor response to angiotensin I at nadir of drug effect and by sustained increases in angiotensin I and renin concentration throughout the period of study.	Enalapril	12-17	renin	Canis lupus familiaris	164-169
2521433-5	1989	Plasma renin activity (PRA), on the other hand, was depressed by aldosterone, falling below the level of detectability.	Aldosterone	65-76	renin	Canis lupus familiaris	7-12
2650928-0	1989	Stimulation of plasma renin activity by captopril in renovascular hypertensive conscious dogs.	Captopril	40-49	renin	Canis lupus familiaris	22-27
2650928-2	1989	This increase in plasma renin activity could result from either the concomitant fall in systemic pressure or other effects of captopril, such as the removal of an angiotensin II inhibitory effect on renin release, the increased production of bradykinin or prostaglandins, etc.	Captopril	126-135	renin	Canis lupus familiaris	24-29
2650928-2	1989	This increase in plasma renin activity could result from either the concomitant fall in systemic pressure or other effects of captopril, such as the removal of an angiotensin II inhibitory effect on renin release, the increased production of bradykinin or prostaglandins, etc.	Prostaglandins	256-270	renin	Canis lupus familiaris	24-29
2650928-4	1989	Plasma renin activity, under normal conditions remained unchanged, while during hypertension it increased 2.0, 2.8 and 3.5 fold respectively in response to the three doses of captopril.	Captopril	175-184	renin	Canis lupus familiaris	7-12
2650928-5	1989	These results suggest that the development of renovascular hypertension sensitized the kidney to release renin when challenged by captopril and that the effect is independent of changes in systemic pressure.	Captopril	130-139	renin	Canis lupus familiaris	105-110
2521228-6	1989	The change in serum sodium concentration correlated with plasma renin activity and aldosterone (r = -0.77, -0.88, respectively, both p less than 0.01), but not with norepinephrine or atrial natriuretic factor.	Sodium	20-26	renin	Canis lupus familiaris	64-69
2541403-2	1989	Renin stimulus-response curves were determined by a stepwise reduction of renal artery pressure down to 70 mm Hg (1) under control conditions, (2) during a bilateral common carotid occlusion combined with an intrarenal prazosin infusion, and (3) during an intrarenal methoxamine infusion.	Prazosin	219-227	renin	Canis lupus familiaris	0-5
2666610-5	1989	We also investigated the inhibitory potency of the renin inhibitor ES-6864 on the renin-like activity in dog tissues (adrenal glands, aorta and brainstem).	ES 6864	67-74	renin	Canis lupus familiaris	82-87
2847552-5	1988	A more moderate increase in plasma renin activity was established in another group of sodium-restricted dogs, and saralasin was administered intravenously instead of intra-arterially.	Sodium	86-92	renin	Canis lupus familiaris	35-40
3065412-9	1988	Intravenous captopril (6 mg/kg per h), for 3 h, led to a sharp increase in dog plasma active renin (from 53 +/- 8 to 360 +/- 60 microU/ml; P less than 0.01, n = 6), whereas inactive renin remained unchanged.	Captopril	12-21	renin	Canis lupus familiaris	93-98
3065412-9	1988	Intravenous captopril (6 mg/kg per h), for 3 h, led to a sharp increase in dog plasma active renin (from 53 +/- 8 to 360 +/- 60 microU/ml; P less than 0.01, n = 6), whereas inactive renin remained unchanged.	Captopril	12-21	renin	Canis lupus familiaris	182-187
3075984-2	1988	An increase in plasma chloride concentration (PC1) decreases renal blood flow (RBF) and glomerular filtration rate (GFR) and inhibits the intrarenal release of renin and angiotensin II (AII).	Chlorides	22-30	renin	Canis lupus familiaris	160-165
2847552-7	1988	The results suggest that blockade of the influence of the renin-angiotensin system and possibly another vasodilator mechanism, such as kinin potentiation, account for the increase in RBF after ACE inhibition in the low-sodium state.	Sodium	219-225	renin	Canis lupus familiaris	58-63
3051994-2	1988	In the anesthetized dog, renin secretion was decreased by renal arterial infusions of calcium chloride and calcium gluconate; aldosterone excretion was not affected.	Calcium Chloride	86-102	renin	Canis lupus familiaris	25-30
3051994-5	1988	In the non-filtering, denervated, papaverine-treated dog kidney, renin release was stimulated by renal arterial infusion of verapamil.	Verapamil	124-133	renin	Canis lupus familiaris	65-70
3067521-1	1988	To examine the relationship between renal release of the prostaglandins E2 (PGE2) and I2 (PGI2) and renin during autoregulatory vasodilation, experiments were performed in anaesthetized dogs with denervated kidneys.	Dinoprostone	57-74	renin	Canis lupus familiaris	100-105
3067521-3	1988	During progressive renal arterial constriction, PGE2 and PGI2 release reached maximal values (10.6 +/- 1.7 for PGE2 and 6.6 +/- 1.1 pmol min-1 for PGI2 release) at RAP of 70-80 mmHg, associated with almost no increase in renin release.	Dinoprostone	48-52	renin	Canis lupus familiaris	221-226
3067521-3	1988	During progressive renal arterial constriction, PGE2 and PGI2 release reached maximal values (10.6 +/- 1.7 for PGE2 and 6.6 +/- 1.1 pmol min-1 for PGI2 release) at RAP of 70-80 mmHg, associated with almost no increase in renin release.	Epoprostenol	57-61	renin	Canis lupus familiaris	221-226
3067521-9	1988	Release of prostaglandins synthetized in arteries consequently occurs at higher RAP than release of renin, which is not enhanced until afferent arterioles ultimately dilate at RAP approaching 60 mmHg.	Prostaglandins	11-25	renin	Canis lupus familiaris	100-105
3052111-1	1988	ACRIP is a competitive inhibitor of renin in which an analogue of statine, (3R,4S)-4-amino-3-hydroxy-6-methylheptanoic acid, is incorporated into analogues of porcine renin substrate.	renin inhibitory peptide, 4-amino-5-cyclohexyl-3-hydroxypentanoic acid	0-5	renin	Canis lupus familiaris	36-41
3052111-1	1988	ACRIP is a competitive inhibitor of renin in which an analogue of statine, (3R,4S)-4-amino-3-hydroxy-6-methylheptanoic acid, is incorporated into analogues of porcine renin substrate.	renin inhibitory peptide, 4-amino-5-cyclohexyl-3-hydroxypentanoic acid	0-5	renin	Canis lupus familiaris	167-172
3052111-1	1988	ACRIP is a competitive inhibitor of renin in which an analogue of statine, (3R,4S)-4-amino-3-hydroxy-6-methylheptanoic acid, is incorporated into analogues of porcine renin substrate.	statine	66-73	renin	Canis lupus familiaris	36-41
3052111-1	1988	ACRIP is a competitive inhibitor of renin in which an analogue of statine, (3R,4S)-4-amino-3-hydroxy-6-methylheptanoic acid, is incorporated into analogues of porcine renin substrate.	statine	66-73	renin	Canis lupus familiaris	167-172
3052111-1	1988	ACRIP is a competitive inhibitor of renin in which an analogue of statine, (3R,4S)-4-amino-3-hydroxy-6-methylheptanoic acid, is incorporated into analogues of porcine renin substrate.	(3R,4S)-4-amino-3-hydroxy-6-methylheptanoic acid	75-123	renin	Canis lupus familiaris	36-41
3052111-1	1988	ACRIP is a competitive inhibitor of renin in which an analogue of statine, (3R,4S)-4-amino-3-hydroxy-6-methylheptanoic acid, is incorporated into analogues of porcine renin substrate.	(3R,4S)-4-amino-3-hydroxy-6-methylheptanoic acid	75-123	renin	Canis lupus familiaris	167-172
3171983-3	1988	No studies have examined the effects of SA on renal function in a situation in which the maintenance of normal kidney function is dependent upon intact renal PG synthesis (i.e., sodium restriction-elevated plasma renin activity).	Sodium	178-184	renin	Canis lupus familiaris	213-218
3171983-8	1988	In the sodium-restricted animals (plasma renin activity, 18-24 ng of angiotensin l/ml/hr) ASA decreased PGE2 excretion but SA did not.	Aspirin	90-93	renin	Canis lupus familiaris	41-46
3171983-8	1988	In the sodium-restricted animals (plasma renin activity, 18-24 ng of angiotensin l/ml/hr) ASA decreased PGE2 excretion but SA did not.	Salicylates	91-93	renin	Canis lupus familiaris	41-46
3293682-7	1988	The degree of tachycardia and increase in plasma renin activity (PRA) for equivalent falls in mean blood pressure in both species was significantly less for flosequinan than for hydralazine (P less than 0.05).	flosequinan	157-168	renin	Canis lupus familiaris	49-54
3293682-7	1988	The degree of tachycardia and increase in plasma renin activity (PRA) for equivalent falls in mean blood pressure in both species was significantly less for flosequinan than for hydralazine (P less than 0.05).	Hydralazine	178-189	renin	Canis lupus familiaris	49-54
3284392-0	1988	Disparity between renal venous norepinephrine and renin responses to sodium depletion.	Sodium	69-75	renin	Canis lupus familiaris	50-55
3284392-3	1988	At this time plasma renin activity (PRA) was increased from a control level (sodium intake = 45 meq/day) of 0.34 +/- 0.08 to 1.47 +/- 0.26 ng angiotensin I (ANG I).ml-1.h-1 in association with an approximately sixfold increase in the PRA gradient across the kidneys.	Sodium	77-83	renin	Canis lupus familiaris	20-25
3279810-1	1988	Experiments were designed to test the hypothesis that epinephrine may act directly on cardiac or pulmonary adrenoceptors to alter the release of a humoral substance that in turn influences renin secretion.	Epinephrine	54-65	renin	Canis lupus familiaris	189-194
3279810-4	1988	At epinephrine infusion rates of 15 and 75 ng.kg-1.min-1, epinephrine-induced changes in renin secretion rates were dose dependent but were independent of the site of infusion.	Epinephrine	3-14	renin	Canis lupus familiaris	89-94
3279810-4	1988	At epinephrine infusion rates of 15 and 75 ng.kg-1.min-1, epinephrine-induced changes in renin secretion rates were dose dependent but were independent of the site of infusion.	Epinephrine	58-69	renin	Canis lupus familiaris	89-94
3279810-7	1988	Intravenous epinephrine infusion at 50 ng.kg-1.min-1 increased plasma renin activity nearly 1.5-fold.	Epinephrine	12-23	renin	Canis lupus familiaris	70-75
3346052-2	1988	Because hypertension could be produced in these dogs without salt loading and unilateral nephrectomy, the research afforded a novel opportunity to determine the primary effects of DOC excess on the renin-angiotensin and sympathetic nervous systems, and on vasopressin levels.	Desoxycorticosterone	180-183	renin	Canis lupus familiaris	198-203
2458109-5	1988	Arotinolol (20 micrograms/min) produced significant suppression of renal nerve stimulation (RNS)-induced renin release and attenuated an increase in renal vascular resistance during RNS at 3 Hz.	arotinolol	0-10	renin	Canis lupus familiaris	105-110
2458109-5	1988	Arotinolol (20 micrograms/min) produced significant suppression of renal nerve stimulation (RNS)-induced renin release and attenuated an increase in renal vascular resistance during RNS at 3 Hz.	Reactive Nitrogen Species	92-95	renin	Canis lupus familiaris	105-110
2458109-6	1988	The same extent of inhibition in the renin secretion response to RNS was also obtained during the infusion of dl-propranolol (100 micrograms/min).	Reactive Nitrogen Species	65-68	renin	Canis lupus familiaris	37-42
2458109-6	1988	The same extent of inhibition in the renin secretion response to RNS was also obtained during the infusion of dl-propranolol (100 micrograms/min).	Propranolol	110-124	renin	Canis lupus familiaris	37-42
2458109-12	1988	These results suggest that arotinolol posesses a- and beta-adrenoceptor blocking properties, which effectively contribute to the suppression of the adrenergically induced renin release and renal vasoconstriction, and to the hypotensive effect.	arotinolol	27-37	renin	Canis lupus familiaris	171-176
3383998-16	1988	Trandolapril produced dose-related (30-1000 micrograms/kg) reductions in BP, total peripheral resistance and heart work in dogs pretreated with hydrochlorothiazide to increase plasma renin activity.	trandolapril	0-12	renin	Canis lupus familiaris	183-188
3383998-16	1988	Trandolapril produced dose-related (30-1000 micrograms/kg) reductions in BP, total peripheral resistance and heart work in dogs pretreated with hydrochlorothiazide to increase plasma renin activity.	Hydrochlorothiazide	144-163	renin	Canis lupus familiaris	183-188
2962784-7	1988	Our data suggest that decrease in atrial pressure below normal results in a decline in pANF, which, acting in concert with the activated renin-angiotensin system and vasopressin, may contribute to sodium retention.	Sodium	197-203	renin	Canis lupus familiaris	137-142
3051994-2	1988	In the anesthetized dog, renin secretion was decreased by renal arterial infusions of calcium chloride and calcium gluconate; aldosterone excretion was not affected.	Calcium Gluconate	107-124	renin	Canis lupus familiaris	25-30
3051994-5	1988	In the non-filtering, denervated, papaverine-treated dog kidney, renin release was stimulated by renal arterial infusion of verapamil.	Papaverine	34-44	renin	Canis lupus familiaris	65-70
3318500-0	1987	Role of prostaglandin in norepinephrine and renin release in canine kidney.	Prostaglandins	8-21	renin	Canis lupus familiaris	44-49
3276221-5	1988	Changes in plasma renin activity were comparable between vehicle and naloxone protocols except that plasma renin activity increased from the first to the second 20-min periods of combined hypoxemia and hypercapnic acidosis with naloxone.	Naloxone	228-236	renin	Canis lupus familiaris	107-112
3280170-5	1988	The chronic elevation of ANG II in the CSF plus an increase in NaCl intake produces a low renin, sodium dependent, expanded volume hypertension.	Sodium Chloride	63-67	renin	Canis lupus familiaris	90-95
3280170-5	1988	The chronic elevation of ANG II in the CSF plus an increase in NaCl intake produces a low renin, sodium dependent, expanded volume hypertension.	Sodium	97-103	renin	Canis lupus familiaris	90-95
3318500-7	1987	These results suggest that renin response to continuous RNS is enhanced by concomitantly generated PGs but not by NE, and furthermore, that endogenously generated PGs do not inhibit the release of NE from canine renal nerve endings.	Reactive Nitrogen Species	56-59	renin	Canis lupus familiaris	27-32
3309520-0	1987	Renin secretion in intact dogs following incubation of epinephrine in blood in vivo.	Epinephrine	55-66	renin	Canis lupus familiaris	0-5
3309520-1	1987	Previous experiments have shown that epinephrine-induced renin secretion in vivo apparently is initiated by activation of extrarenal adrenoceptors.	Epinephrine	37-48	renin	Canis lupus familiaris	57-62
3309520-8	1987	Intravenous infusion of epinephrine at 25 ng X kg-1 X min-1 increased renin secretion significantly.	Epinephrine	24-35	renin	Canis lupus familiaris	70-75
3318501-0	1987	Effects of altered NaCl intake on renal hemodynamic and renin release responses to RNS.	Sodium Chloride	19-23	renin	Canis lupus familiaris	56-61
3318501-8	1987	These data indicate that renal vasoconstrictor responses to RNS are potentiated, and renin release responses to RNS are reduced by elevation of sodium chloride intake.	Reactive Nitrogen Species	112-115	renin	Canis lupus familiaris	85-90
3318501-8	1987	These data indicate that renal vasoconstrictor responses to RNS are potentiated, and renin release responses to RNS are reduced by elevation of sodium chloride intake.	Sodium Chloride	144-159	renin	Canis lupus familiaris	85-90
3318501-9	1987	We suggest that during low sodium intake, activation of sympathetic nerve activity elicits an enhanced renin release response, whereas the renal vasculature may be protected against neurogenic vasoconstriction.	Sodium	27-33	renin	Canis lupus familiaris	103-108
3298573-2	1987	In two-kidney, one-clip (renin-dependent) hypertension, captopril (1.5 mg/kg bolus with 1.5 mg/min infusion) reduced mean arterial pressure (MAP) and ipsilateral glomerular filtration rate (GFR) without changes in the contralateral kidney.	Captopril	56-65	renin	Canis lupus familiaris	25-30
2889779-7	1987	Captopril administration after alpha 1-blockade caused further reductions in MAP and IVR in the hypertensives, and in the MAP of the normotensive dogs on normal or high salt, indicating that the renin-angiotensin system maintained blood pressure in these groups.	Captopril	0-9	renin	Canis lupus familiaris	195-200
3322825-4	1987	The rise in plasma renin activity following diltiazem 0.02 mg kg-1 or 0.1 mg kg-1 or nifedipine 0.01 mg kg-1 was similar to values in a control group, whereas in those receiving verapamil 0.15 mg kg-1 or 0.6 mg kg-1, or nifedipine 0.05 mg kg-1, the rise was greater.	Diltiazem	44-53	renin	Canis lupus familiaris	19-24
3322825-4	1987	The rise in plasma renin activity following diltiazem 0.02 mg kg-1 or 0.1 mg kg-1 or nifedipine 0.01 mg kg-1 was similar to values in a control group, whereas in those receiving verapamil 0.15 mg kg-1 or 0.6 mg kg-1, or nifedipine 0.05 mg kg-1, the rise was greater.	Nifedipine	85-95	renin	Canis lupus familiaris	19-24
3322825-4	1987	The rise in plasma renin activity following diltiazem 0.02 mg kg-1 or 0.1 mg kg-1 or nifedipine 0.01 mg kg-1 was similar to values in a control group, whereas in those receiving verapamil 0.15 mg kg-1 or 0.6 mg kg-1, or nifedipine 0.05 mg kg-1, the rise was greater.	Verapamil	178-187	renin	Canis lupus familiaris	19-24
3322825-4	1987	The rise in plasma renin activity following diltiazem 0.02 mg kg-1 or 0.1 mg kg-1 or nifedipine 0.01 mg kg-1 was similar to values in a control group, whereas in those receiving verapamil 0.15 mg kg-1 or 0.6 mg kg-1, or nifedipine 0.05 mg kg-1, the rise was greater.	Nifedipine	220-230	renin	Canis lupus familiaris	19-24
3298573-5	1987	These studies suggest that the [99mTc]DTPA renal flow study coupled with captopril challenge may unmask intrarenal angiotensin II-dependent functional and hemodynamic changes of the stenotic kidney, and offers promise in the detection of renin-dependent hypertension.	Pentetic Acid	38-42	renin	Canis lupus familiaris	238-243
3555078-3	1987	Prostaglandin D2 administration resulted in a significant dose-dependent increase in renal artery flow, urine output, creatinine clearance, plasma renin activity, sodium excretion, potassium excretion, and pulmonary artery pressure.	Prostaglandin D2	0-16	renin	Canis lupus familiaris	147-152
3496362-1	1987	Epidermal growth factor-urogastrone (EGF-URO) administered intraarterially was a potent dilator in dog femoral (FEM), superior (cephalic) mesenteric (SMA), celiac (CAC), coronary (COR), carotid (CAR), and renal (REN) vascular beds.	3-(1H-imidazol-4-yl)propanoic acid	41-44	renin	Canis lupus familiaris	212-215
3496362-4	1987	The ED50 for this effect of EGF-URO was in the range of 0.4 micrograms (FEM, SMA, CAR, and COR) to 0.9 micrograms (CAC and REN).	3-(1H-imidazol-4-yl)propanoic acid	32-35	renin	Canis lupus familiaris	123-126
3032515-8	1987	Plasma renin activity and angiotensin I concentration increased after oleic acid injection.	Oleic Acid	70-80	renin	Canis lupus familiaris	7-12
3106984-0	1987	Role of intracellular calcium in renal nerve-mediated renin release.	Calcium	22-29	renin	Canis lupus familiaris	54-59
3106984-12	1987	The present study suggests that increased intracellular Ca by Io inhibits renal nerve-mediated renin release.	Calcimycin	62-64	renin	Canis lupus familiaris	95-100
3106984-14	1987	A high dose of verapamil increases renin release but does not enhance RNS-mediated renin release.	Verapamil	15-24	renin	Canis lupus familiaris	35-40
3106984-15	1987	We conclude that intracellular calcium plays an important role in renin release and may be the final messenger in renal nerve-mediated renin release.	Calcium	31-38	renin	Canis lupus familiaris	66-71
3106984-15	1987	We conclude that intracellular calcium plays an important role in renin release and may be the final messenger in renal nerve-mediated renin release.	Calcium	31-38	renin	Canis lupus familiaris	135-140
3573987-1	1987	Sodium depletion in dogs is known to affect both the renin-angiotensin as well as the sympathetic nervous system.	Sodium	0-6	renin	Canis lupus familiaris	53-58
3551630-5	1987	These findings indicate that in fistula dogs enhanced medullary sodium reabsorption is associated with decreased PPF and stimulation of the renin-angiotensin and adrenergic nervous system.	Sodium	64-70	renin	Canis lupus familiaris	140-145
3325200-7	1987	The results of the present study suggest that captopril acts by inhibiting vascular sympathetic neuronal function when the activity of the renin-angiotensin system is elevated.	Captopril	46-55	renin	Canis lupus familiaris	139-144
3039218-8	1987	Plasma renin activity and plasma Ang I concentration increased by repeated SA446 application, while plasma aldosterone concentration decreased.	rentiapril	75-80	renin	Canis lupus familiaris	7-12
3549165-0	1987	Peripherally delivered renin supports reflex adrenal catecholamine secretion in anephric dogs.	Catecholamines	53-66	renin	Canis lupus familiaris	23-28
2434783-0	1987	Effects of K-351 on adrenergically induced renin release and renal vasoconstriction in anesthetized dogs.	nipradilol	11-16	renin	Canis lupus familiaris	43-48
2434783-4	1987	The same extent of inhibition in the renin secretion response to RNS was also obtained during infusion of DL-propranolol (100 micrograms/min).	Reactive Nitrogen Species	65-68	renin	Canis lupus familiaris	37-42
2434783-4	1987	The same extent of inhibition in the renin secretion response to RNS was also obtained during infusion of DL-propranolol (100 micrograms/min).	Propranolol	106-120	renin	Canis lupus familiaris	37-42
2434783-8	1987	These results suggest that K-351 shares beta- and alpha-adrenoceptor blocking properties, which effectively contribute to the suppression of adrenergically induced renin release and renal vasoconstriction.	nipradilol	27-32	renin	Canis lupus familiaris	164-169
3538901-3	1986	Direct renal artery (ia) infusion of the alpha-adrenoceptor agonist phenylephrine, 0.25 or 0.50 microgram X kg-1 X min-1 for 30 min, increased plasma renin activity (PRA) to 145 +/- 13 and 212 +/- 28% of control, respectively, within 5 min of drug infusion (P less than 0.01) in conscious sodium-replete dogs.	Phenylephrine	68-81	renin	Canis lupus familiaris	150-155
3533395-3	1986	In sodium replete animals captopril induced a small decrease in blood pressure, transient increases in effective renal plasma flow and urinary 6-keto-PGF1 alpha excretion, and progressive increases in plasma renin activity (PRA) and urinary sodium excretion.	Captopril	26-35	renin	Canis lupus familiaris	208-213
2945673-7	1986	There was an excellent correlation between plasma norepinephrine and renin activity before the animals were killed in both the VP1 and VP2 groups (r = .88, p less than .001).	Norepinephrine	50-64	renin	Canis lupus familiaris	69-74
3531005-4	1986	Furthermore, a greater renal vasodilation induced by intrarenal bolus injections of nifedipine (1,3, and 10 micrograms) but not by acetylcholine (0.1 and 0.3 microgram) was observed during the reduction in the perfusion pressure of the contralateral kidney to approximately 50 mm Hg, which resulted in an increase in plasma renin activity and plasma angiotensin II concentration but no change in plasma norepinephrine concentration.	Nifedipine	84-94	renin	Canis lupus familiaris	324-329
3531005-5	1986	There was a significant positive correlation between plasma renin activity and plasma angiotensin II concentration before nifedipine injections and the subsequent increase in renal blood flow produced by each dose of nifedipine.	Nifedipine	122-132	renin	Canis lupus familiaris	60-65
3531005-5	1986	There was a significant positive correlation between plasma renin activity and plasma angiotensin II concentration before nifedipine injections and the subsequent increase in renal blood flow produced by each dose of nifedipine.	Nifedipine	217-227	renin	Canis lupus familiaris	60-65
2944396-5	1986	The increase of sodium intake from 5 to 75 meq/day produced decreases of plasma renin activity (PRA) (2.5 +/- 0.5 to 1.5 +/- 0.4 ng angiotensin I X ml-1 X h-1, P less than 0.05), plasma aldosterone concentration (PAC) (19.3 +/- 5.4 to 2.9 +/- 0.4 pg/ml, P less than 0.05), and urinary excretion of prostaglandin E2 (760 +/- 131 to 320 +/- 58 pg/min, P less than 0.05).	Sodium	16-22	renin	Canis lupus familiaris	80-85
3539582-0	1986	Changes in central and peripheral renin-angiotensin system after furosemide injection.	Furosemide	65-75	renin	Canis lupus familiaris	34-39
3529989-7	1986	Significant and progressive increases in plasma vasopressin concentration and renin activity were observed during water deprivation, but plasma aldosterone did not change from control levels.	Water	114-119	renin	Canis lupus familiaris	78-83
3090282-5	1986	The renin-angiotensin response at 3 minutes differed between nitroglycerin infusions of 1 and 10 micrograms/kg/min with an initial significant reduction from baseline in plasma renin activity at the lower dose compared with a significant increase from baseline in plasma activity at the higher dose.	Nitroglycerin	61-74	renin	Canis lupus familiaris	4-9
3524271-0	1986	Suppression of plasma renin and aldosterone in stress-salt hypertension in dogs.	Salts	54-58	renin	Canis lupus familiaris	22-27
3524271-8	1986	These results show that high sodium intake decreased aldosterone via suppression of renin release but do not rule out a possible hypertensinogenic role for stress-induced adrenocorticotrophic hormone-sensitive corticoids.	Sodium	29-35	renin	Canis lupus familiaris	84-89
3519811-4	1986	Adenosine infusion was also accompanied by a significant reduction of plasma renin activity, from 8.4 +/- 0.6 ng/ml/hour to 3.8 +/- 0.4 ng/ml/hour.	Adenosine	0-9	renin	Canis lupus familiaris	77-82
3519811-6	1986	Allopurinol also prevented the decrease of plasma renin activity, for which the average values recorded before and after adenosine were 9.6 +/- 0.6 ng/ml/hour and 8.2 +/- 0.6 ng/ml/hour, respectively.	Allopurinol	0-11	renin	Canis lupus familiaris	50-55
3519811-6	1986	Allopurinol also prevented the decrease of plasma renin activity, for which the average values recorded before and after adenosine were 9.6 +/- 0.6 ng/ml/hour and 8.2 +/- 0.6 ng/ml/hour, respectively.	Adenosine	121-130	renin	Canis lupus familiaris	50-55
3519811-7	1986	The results of this study indicate that allopurinol exerts specific effects on the vasodilatory component of adenosine and prevents the adenosine-suppressive effect on the renin-angiotensin system.	Allopurinol	40-51	renin	Canis lupus familiaris	172-177
3519811-7	1986	The results of this study indicate that allopurinol exerts specific effects on the vasodilatory component of adenosine and prevents the adenosine-suppressive effect on the renin-angiotensin system.	Adenosine	136-145	renin	Canis lupus familiaris	172-177
3521329-0	1986	Interaction between epinephrine and renal nerves in control of renin secretion rate.	Epinephrine	20-31	renin	Canis lupus familiaris	63-68
3521329-1	1986	To determine whether the increase in renin secretion rate (RSR) produced by the beta 2-adrenoceptor agonist epinephrine was dependent on intact renal innervation, epinephrine (10 ng X kg-1 X min-1) was infused bilaterally into an innervated and a denervated kidney (ira) of the same anesthetized dog at spontaneous and reduced renal arterial pressure (decreases RAP, 100 mmHg).	Epinephrine	108-119	renin	Canis lupus familiaris	37-42
3090282-5	1986	The renin-angiotensin response at 3 minutes differed between nitroglycerin infusions of 1 and 10 micrograms/kg/min with an initial significant reduction from baseline in plasma renin activity at the lower dose compared with a significant increase from baseline in plasma activity at the higher dose.	Nitroglycerin	61-74	renin	Canis lupus familiaris	177-182
2941371-4	1986	This fall in renin secretion was associated with significant increases (p less than 0.05) in creatinine clearance, urine flow, sodium excretion, and the filtered load of sodium.	Creatinine	93-103	renin	Canis lupus familiaris	13-18
2941371-4	1986	This fall in renin secretion was associated with significant increases (p less than 0.05) in creatinine clearance, urine flow, sodium excretion, and the filtered load of sodium.	Sodium	127-133	renin	Canis lupus familiaris	13-18
2941371-4	1986	This fall in renin secretion was associated with significant increases (p less than 0.05) in creatinine clearance, urine flow, sodium excretion, and the filtered load of sodium.	Sodium	170-176	renin	Canis lupus familiaris	13-18
2941371-9	1986	These results suggest that an increase in the sodium load delivered to the macula suppression of renin secretion by atrial natriuretic factor is mediated through its interactions with the two intrarenal receptor mechanisms, the renal vascular receptor and the macula densa.	Sodium	46-52	renin	Canis lupus familiaris	97-102
2948065-5	1986	r-AP III caused a slight increase in plasma renin activity from 0.65 +/- 0.46 in controls to 1.02 +/- 0.47 ng X ml-1 X h-1 in water diuretic dogs and from 3.19 +/- 0.51 in controls to 3.72 +/- 0.81 ng X ml-1 X h-1 in hydropenic dogs.	Water	126-131	renin	Canis lupus familiaris	44-49
3521934-9	1986	In sodium-depleted dogs, inhibition of the renin-angiotensin system with saralasin or captopril produced an opposite shift.	Saralasin	73-82	renin	Canis lupus familiaris	43-48
3521934-9	1986	In sodium-depleted dogs, inhibition of the renin-angiotensin system with saralasin or captopril produced an opposite shift.	Captopril	86-95	renin	Canis lupus familiaris	43-48
3525194-0	1986	Cerebral renin-angiotensin mediation of isoproterenol-induced thirst in the dog.	Isoproterenol	40-53	renin	Canis lupus familiaris	9-14
3525194-1	1986	Pretreatment of dogs with s.c. isoproterenol (10 micrograms/kg) caused a significant increase in drinking when 100 ng renin substrate was administered 3 min later to the lateral cerebral ventricles or subfornical organ.	Isoproterenol	31-44	renin	Canis lupus familiaris	118-123
2939730-4	1986	Adenosine, however, known to directly inhibit renin secretion, did decrease renin secretion in this nonfiltering model.	Adenosine	0-9	renin	Canis lupus familiaris	46-51
2939730-4	1986	Adenosine, however, known to directly inhibit renin secretion, did decrease renin secretion in this nonfiltering model.	Adenosine	0-9	renin	Canis lupus familiaris	76-81
3522250-0	1986	Effects of histamine-receptor antagonists on histamine-stimulated renin secretion.	Histamine	11-20	renin	Canis lupus familiaris	66-71
3522250-2	1986	Tripelennamine (H1 blocker) further enhanced renin secretion in the presence of exogenous histamine.	Tripelennamine	0-14	renin	Canis lupus familiaris	45-50
3522250-3	1986	Moreover, tripelennamine alone increased renin secretion.	Tripelennamine	10-24	renin	Canis lupus familiaris	41-46
3522250-5	1986	Conversely, cimetidine (H2 blocker) significantly inhibited histamine-induced increases in renin secretion, renal blood flow, and sodium excretion without any changes in mean arterial blood pressure or glomerular filtration rate.	Cimetidine	12-22	renin	Canis lupus familiaris	91-96
3522250-5	1986	Conversely, cimetidine (H2 blocker) significantly inhibited histamine-induced increases in renin secretion, renal blood flow, and sodium excretion without any changes in mean arterial blood pressure or glomerular filtration rate.	Histamine	60-69	renin	Canis lupus familiaris	91-96
3522250-7	1986	We conclude that H2 receptors mediate the effect of histamine on renin secretion in dogs with innervated, intact kidneys.	Histamine	52-61	renin	Canis lupus familiaris	65-70
3515972-0	1986	Suppression of renin release by antagonism of endogenous opiates in the dog.	Opiate Alkaloids	57-64	renin	Canis lupus familiaris	15-20
3515972-3	1986	Acute antagonism of endogenous opiates abolished the increase in plasma renin activity and mean arterial pressure associated with renal arterial constriction.	Opiate Alkaloids	31-38	renin	Canis lupus familiaris	72-77
3515972-5	1986	In chronic preparations long-term naloxone infusion attenuated the development of renovascular hypertension and diminished the increase in plasma renin activity.	Naloxone	34-42	renin	Canis lupus familiaris	146-151
3018232-1	1986	We have studied the influence of the renin-angiotensin system on the control of catecholamine release from innervated and denervated adrenal glands of anaesthetized dogs.	Catecholamines	80-93	renin	Canis lupus familiaris	37-42
3005777-15	1986	The resumption of normal renal cortical blood flow after the administration of the converting enzyme inhibitor MK422 suggests that elevated plasma renin activity may contribute to renal dysfunction after thoracic aortic occlusion.	Enalaprilat	111-116	renin	Canis lupus familiaris	147-152
3519923-12	1986	Intravenous injection of pinacidil or hydralazine produced a significant increase in the renin secretion rate.	Pinacidil	25-34	renin	Canis lupus familiaris	89-94
3519923-12	1986	Intravenous injection of pinacidil or hydralazine produced a significant increase in the renin secretion rate.	Hydralazine	38-49	renin	Canis lupus familiaris	89-94
3029438-3	1987	Renin-angiotensin system blockade with the converting enzyme inhibitor, MK422, resulted in restoration of baseline renal blood flow and glomerular filtration 30 minutes after cross-clamp release.	Enalaprilat	72-77	renin	Canis lupus familiaris	0-5
2425184-0	1986	Effects of nifedipine on renin release and renal function in anesthetized dogs.	Nifedipine	11-21	renin	Canis lupus familiaris	25-30
2425184-6	1986	Renin secretion rate was increased to three times the preinfusion level during infusion of the highest nifedipine dose.	Nifedipine	103-113	renin	Canis lupus familiaris	0-5
2425184-8	1986	These results suggest that a nonhypotensive dose of nifedipine causes an increase in renin secretion and that this drug has a striking effect on the reabsorption of sodium and water by the renal tubules.	Nifedipine	52-62	renin	Canis lupus familiaris	85-90
3513620-0	1986	Chronic effects of vasopressin on plasma renin activity in sodium-restricted dogs.	Sodium	59-65	renin	Canis lupus familiaris	41-46
3510566-8	1986	A specific antagonist of the vasoconstrictor activity of vasopressin, d(CH2)5MeTyrAVP (10 micrograms/kg), completely blocked the cardiovascular and renin responses to vasopressin.	d(ch2)5metyravp	70-85	renin	Canis lupus familiaris	148-153
3006712-0	1986	Effect of alacepril on renin-angiotensin-aldosterone system and kallikrein-kinin-prostaglandin system in experimental animals.	alacepril	10-19	renin	Canis lupus familiaris	23-28
3006712-8	1986	These results indicate that the antihypertensive activity of alacepril is due to the suppression of renin-angiotensin-aldosterone system and the enhancement of kallikrein-kinin-prostaglandin system through the inhibition of ACE (kininase II) activity in vivo.	alacepril	61-70	renin	Canis lupus familiaris	100-105
2419690-8	1986	The rise in plasma catecholamines and plasma renin activity was greatest with nifedipine, least with nitroprusside, and intermediate with diltiazem.	Nifedipine	78-88	renin	Canis lupus familiaris	45-50
2419690-8	1986	The rise in plasma catecholamines and plasma renin activity was greatest with nifedipine, least with nitroprusside, and intermediate with diltiazem.	Nitroprusside	101-114	renin	Canis lupus familiaris	45-50
2419690-8	1986	The rise in plasma catecholamines and plasma renin activity was greatest with nifedipine, least with nitroprusside, and intermediate with diltiazem.	Diltiazem	138-147	renin	Canis lupus familiaris	45-50
3520511-8	1986	These results indicate that the inhibition of renin secretion by vasopressin in anesthetized water-loaded dogs is due to its antidiuretic activity.	Water	93-98	renin	Canis lupus familiaris	46-51
3903010-0	1985	Influence of plasma renin content, intrarenal angiotensin II, captopril, and calcium channel blockers on the vasoconstriction and renin release promoted by adenosine in the kidney.	Adenosine	156-165	renin	Canis lupus familiaris	20-25
3903010-0	1985	Influence of plasma renin content, intrarenal angiotensin II, captopril, and calcium channel blockers on the vasoconstriction and renin release promoted by adenosine in the kidney.	Adenosine	156-165	renin	Canis lupus familiaris	130-135
3903010-1	1985	Our study was undertaken to assess whether the effect of intrarenal infusion of adenosine on renal blood flow and renin release in dogs is modified by the degree of stimulation of the intrarenal renin-angiotensin system.	Adenosine	80-89	renin	Canis lupus familiaris	114-119
3903010-1	1985	Our study was undertaken to assess whether the effect of intrarenal infusion of adenosine on renal blood flow and renin release in dogs is modified by the degree of stimulation of the intrarenal renin-angiotensin system.	Adenosine	80-89	renin	Canis lupus familiaris	195-200
3903010-5	1985	In all cases adenosine inhibited the renal secretion of renin.	Adenosine	13-22	renin	Canis lupus familiaris	56-61
3892214-0	1985	Effect of intravenous epinephrine infusion on plasma renin activity in adrenalectomized dogs.	Epinephrine	22-33	renin	Canis lupus familiaris	53-58
3929625-6	1985	We also observed that after 3 h of hypotension there was a significantly smaller increase in plasma renin activity in the salt-pretreated dogs.	Salts	122-126	renin	Canis lupus familiaris	100-105
3929625-7	1985	Administration of 0.1 U X kg-1 X min-1 of hog renin eliminated the differences in systemic vascular resistance, cardiac output, and survival in five salt-pretreated dogs.	Salts	149-153	renin	Canis lupus familiaris	46-51
2866274-13	1985	Plasma renin activity was significantly decreased after S 3341 treatment in dogs on low normal or high sodium diets.	Sodium	103-109	renin	Canis lupus familiaris	7-12
3892214-1	1985	Previous experiments have shown that circulating epinephrine stimulates renin secretin and increases plasma renin activity (PRA) when it is infused intravenously, but not when it is infused directly into the renal artery at similar infusion rates.	Epinephrine	49-60	renin	Canis lupus familiaris	72-77
3892214-1	1985	Previous experiments have shown that circulating epinephrine stimulates renin secretin and increases plasma renin activity (PRA) when it is infused intravenously, but not when it is infused directly into the renal artery at similar infusion rates.	Epinephrine	49-60	renin	Canis lupus familiaris	108-113
2861715-2	1985	The enhancement of renin release during autoregulated vasodilation might be mediated by prostaglandins.	Prostaglandins	88-102	renin	Canis lupus familiaris	19-24
2861715-5	1985	After administration of indomethacin (10 mg X kg-1 b.wt), PGE2 release was effectively blocked and constriction of the renal artery raised renin release only from 0.1 +/- 0.1 to 6 +/- 1 micrograms AI X min-1.	Indomethacin	24-36	renin	Canis lupus familiaris	139-144
2861715-6	1985	During subsequent continuous infusion of a beta-adrenergic agonist, isoproterenol (0.2 micrograms X kg-1 X min-1), constriction of the renal artery raised renin release from 0.1 +/- 0.1 to 52 +/- 11 micrograms AI X min-1, although there was no rise in PGE2 release.	Isoproterenol	68-81	renin	Canis lupus familiaris	155-160
2861715-7	1985	In six dogs, intrarenal infusion of phenylephrine, an alpha- adrenergic agonist, increased PGE2 and renin release before, but not after, indomethacin administration.	Phenylephrine	36-49	renin	Canis lupus familiaris	100-105
2861715-8	1985	In six other dogs, phenylephrine infused during isoproterenol infusion increased renin release equally before and after indomethacin administration.	Phenylephrine	19-32	renin	Canis lupus familiaris	81-86
2861715-8	1985	In six other dogs, phenylephrine infused during isoproterenol infusion increased renin release equally before and after indomethacin administration.	Isoproterenol	48-61	renin	Canis lupus familiaris	81-86
2861715-10	1985	We propose that autoregulated dilation enhances renin release whether the stimulatory agent is a prostaglandin or a beta-adrenergic agonist.	Prostaglandins	97-110	renin	Canis lupus familiaris	48-53
2993720-2	1985	Intrarenal infusion of the larger dose of SA-446 (0.1 mg/min) caused an increase in RBF, urine flow and renin release and caused a fall in blood pressure.	2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine	42-44	renin	Canis lupus familiaris	104-109
3925129-0	1985	Autoregulatory vasodilation enhances renal prostaglandin E2 and associated renin release during arachidonic acid infusion in dogs.	Arachidonic Acid	96-112	renin	Canis lupus familiaris	75-80
3925129-5	1985	Arachidonic acid infusion (160 micrograms X kg-1 X min-1) raised renin release by 6 +/- 2 micrograms of angiotensin I per min at control pressures, by 25 +/- 9 micrograms of angiotensin I per min during renal arterial constriction and during ureteral occlusion by 16 +/- 4 micrograms of angiotensin I per min, which was not significantly higher than induced by the lower rate of infusion.	Arachidonic Acid	0-16	renin	Canis lupus familiaris	65-70
3925129-8	1985	Both increased intrarenal PG concentration and autoregulatory dilation may contribute to enhancement of renin release.	pg	26-28	renin	Canis lupus familiaris	104-109
3884173-7	1985	Nitroprusside increased renin secretion not only by an increase in sympathetic beta adrenergic activity through the baroreceptor reflex, but also by its direct vasolidatory effect in the renal circulation.	Nitroprusside	0-13	renin	Canis lupus familiaris	24-29
2987127-7	1985	Infusion of a maximally effective dose of a statine-containing renin inhibitor (SCRIP) with the high dose of enalaprilat produced no further fall in blood pressure (68 +/- 7 mm Hg), but immunoreactive angiotensin II levels fell to essentially zero in four of five dogs.	statine	44-51	renin	Canis lupus familiaris	63-68
2987127-7	1985	Infusion of a maximally effective dose of a statine-containing renin inhibitor (SCRIP) with the high dose of enalaprilat produced no further fall in blood pressure (68 +/- 7 mm Hg), but immunoreactive angiotensin II levels fell to essentially zero in four of five dogs.	Enalaprilat	109-120	renin	Canis lupus familiaris	63-68
3893341-0	1985	Renin response to captopril in conscious dogs pretreated with indomethacin or propranolol.	Captopril	18-27	renin	Canis lupus familiaris	0-5
3893341-0	1985	Renin response to captopril in conscious dogs pretreated with indomethacin or propranolol.	Indomethacin	62-74	renin	Canis lupus familiaris	0-5
3893341-0	1985	Renin response to captopril in conscious dogs pretreated with indomethacin or propranolol.	Propranolol	78-89	renin	Canis lupus familiaris	0-5
3893341-1	1985	The present experiments were undertaken to examine the involvement of prostaglandins and intrarenal beta-adrenergic system in captopril-induced renin release using conscious dogs.	Captopril	126-135	renin	Canis lupus familiaris	144-149
3893341-2	1985	In a first series of experiments, plasma renin activity (PRA) increased 2.5- to 5.2-fold after captopril (1 mg/kg, i.v.)	Captopril	95-104	renin	Canis lupus familiaris	41-46
3893341-9	1985	Statistical analysis did not give a definite evidence that propranolol inhibits captopril-induced renin release.	Propranolol	59-70	renin	Canis lupus familiaris	98-103
3919521-0	1985	Renin release during controlled hypotension with sodium nitroprusside, nitroglycerin and adenosine: a comparative study in the dog.	Nitroprusside	49-69	renin	Canis lupus familiaris	0-5
3919521-0	1985	Renin release during controlled hypotension with sodium nitroprusside, nitroglycerin and adenosine: a comparative study in the dog.	Nitroglycerin	71-84	renin	Canis lupus familiaris	0-5
3919521-0	1985	Renin release during controlled hypotension with sodium nitroprusside, nitroglycerin and adenosine: a comparative study in the dog.	Adenosine	89-98	renin	Canis lupus familiaris	0-5
3919521-11	1985	We conclude that adenosine differs markedly from conventional hypotensive drugs such as SNP and TNG with respect to stability of action and dose requirements, and that this stability is related to an inhibited increase in renin release.	Adenosine	17-26	renin	Canis lupus familiaris	222-227
3885800-0	1985	[Plasma renin activity and prostaglandin E2 in hypotension induced by sodium nitroprusside].	Nitroprusside	70-90	renin	Canis lupus familiaris	8-13
3893236-0	1985	[Plasma renin activity and prostaglandin E2 in hypotension induced by nicergoline].	Nicergoline	70-81	renin	Canis lupus familiaris	8-13
2983567-4	1985	beta-Adrenoceptor blockade with propranolol blunted the renin secretion rate (RSR) response to graded RNS (0.3-5.0 Hz), but the extent of inhibition during low-frequency RNS was dependent on RPP.	Propranolol	32-43	renin	Canis lupus familiaris	56-61
2983567-4	1985	beta-Adrenoceptor blockade with propranolol blunted the renin secretion rate (RSR) response to graded RNS (0.3-5.0 Hz), but the extent of inhibition during low-frequency RNS was dependent on RPP.	Reactive Nitrogen Species	102-105	renin	Canis lupus familiaris	56-61
3881984-1	1985	Several investigators have reported that hepatic metabolism of renin can be altered in pathophysiological states (e.g., high-output heart failure, cirrhosis, acute metal toxicity).	Metals	164-169	renin	Canis lupus familiaris	63-68
3881984-4	1985	The administration of captopril resulted in a significant fall in the percent extraction of renin by the liver (P less than 0.01) and in the clearance of renin (P less than 0.05).	Captopril	22-31	renin	Canis lupus familiaris	92-97
3881984-4	1985	The administration of captopril resulted in a significant fall in the percent extraction of renin by the liver (P less than 0.01) and in the clearance of renin (P less than 0.05).	Captopril	22-31	renin	Canis lupus familiaris	154-159
3881984-7	1985	The mechanism by which captopril alters renin metabolism appears to be independent of its blockade of angiotensin II.	Captopril	23-32	renin	Canis lupus familiaris	40-45
6149693-1	1984	The relationship between renin release and renal prostaglandin (PG) production induced by the alpha-agonists methoxamine and alpha-methylnorepinephrine was examined in anesthetized dogs.	Prostaglandins	49-62	renin	Canis lupus familiaris	25-30
3892078-2	1985	Acute administration of furosemide led to a significant increase in plasma renin activity, plasma noradrenaline levels and heart rate, and also to a slight rise of blood pressure.	Furosemide	24-34	renin	Canis lupus familiaris	75-80
3887117-5	1985	The plasma renin activity increased with hypercapnic acidosis in both water loaded and euvolemic dogs.	Water	70-75	renin	Canis lupus familiaris	11-16
6096280-5	1984	However, after metoprolol, a beta 1-adrenergic blocking agent that blocks the rise in plasma renin activity during exercise, swimming causes a threefold increase in albuminuria (P less than 0.01).	Metoprolol	15-25	renin	Canis lupus familiaris	93-98
2409456-1	1985	Studies were undertaken to extend previous experiments of the interaction between calcium and parathyroid hormone on renin synthesis by the kidney.	Calcium	82-89	renin	Canis lupus familiaris	117-122
3895331-5	1985	At a perfusion pressure below the range of autoregulation, saline infusion restored sodium excretion and reduced renin release but did not alter PGE2 release.	Sodium Chloride	59-65	renin	Canis lupus familiaris	113-118
3895331-7	1985	Prostaglandins enhance renin release when afferent arterioles are dilated.	Prostaglandins	0-14	renin	Canis lupus familiaris	23-28
6388358-0	1984	Interactions among renal nerves, prostaglandins, and renal arterial pressure in the regulation of renin release.	Prostaglandins	33-47	renin	Canis lupus familiaris	98-103
6388358-2	1984	LFRNS, which did not affect renal hemodynamics or urinary sodium excretion, increased renin secretion rate before (79 +/- 16 ng/min) but significantly less after renal arterial administration of indomethacin or meclofenamate (26 +/- 7 ng/min).	Indomethacin	195-207	renin	Canis lupus familiaris	86-91
6149693-1	1984	The relationship between renin release and renal prostaglandin (PG) production induced by the alpha-agonists methoxamine and alpha-methylnorepinephrine was examined in anesthetized dogs.	Prostaglandins	64-66	renin	Canis lupus familiaris	25-30
6149693-1	1984	The relationship between renin release and renal prostaglandin (PG) production induced by the alpha-agonists methoxamine and alpha-methylnorepinephrine was examined in anesthetized dogs.	Methoxamine	109-120	renin	Canis lupus familiaris	25-30
6149693-1	1984	The relationship between renin release and renal prostaglandin (PG) production induced by the alpha-agonists methoxamine and alpha-methylnorepinephrine was examined in anesthetized dogs.	Nordefrin	125-151	renin	Canis lupus familiaris	25-30
6149693-3	1984	Methoxamine dose-dependently increased the renin secretion rate but failed to increase the PGE2 secretion rate.	Methoxamine	0-11	renin	Canis lupus familiaris	43-48
6149693-5	1984	The effect of methoxamine (5 micrograms/min) on renin release was abolished by the intrarenal alpha 1-adrenoceptor blockade with prazosin (3 micrograms/min) but was not affected by the intrarenal alpha 2-adrenoceptor blockade with yohimbine (30 micrograms/min).	Methoxamine	14-25	renin	Canis lupus familiaris	48-53
6149693-5	1984	The effect of methoxamine (5 micrograms/min) on renin release was abolished by the intrarenal alpha 1-adrenoceptor blockade with prazosin (3 micrograms/min) but was not affected by the intrarenal alpha 2-adrenoceptor blockade with yohimbine (30 micrograms/min).	Prazosin	129-137	renin	Canis lupus familiaris	48-53
6149693-5	1984	The effect of methoxamine (5 micrograms/min) on renin release was abolished by the intrarenal alpha 1-adrenoceptor blockade with prazosin (3 micrograms/min) but was not affected by the intrarenal alpha 2-adrenoceptor blockade with yohimbine (30 micrograms/min).	Yohimbine	231-240	renin	Canis lupus familiaris	48-53
6092626-0	1984	Mechanism of effect of dibutyryl cyclic adenosine 3",5"-monophosphate on canine renal renin release.	Bucladesine	23-69	renin	Canis lupus familiaris	86-91
6093556-0	1984	Na+-K+-ATPase inhibitors and renin release: relationship to calcium.	Calcium	60-67	renin	Canis lupus familiaris	29-34
6093556-7	1984	The data strongly suggest that calcium entry into cells is a major mediator of the renin inhibitory effect and of the renal vasoconstriction induced by cardiac glycosides.	Calcium	31-38	renin	Canis lupus familiaris	83-88
6093556-9	1984	Superimposition of vanadate (0.5 mumol/min) on ouabain infusion led to massive natriuresis (FENa, 5 +/- 1----35 +/- 4%), renal vasodilation (RBF 90 +/- 12----170 +/- 15 ml/min), and an increase in renin secretion (delta, 100%).	Vanadates	19-27	renin	Canis lupus familiaris	197-202
6092626-1	1984	We evaluated the effect of intrarenal arterial infusion of dibutyryl cyclic AMP on renal renin release.	Bucladesine	59-79	renin	Canis lupus familiaris	89-94
6092626-2	1984	Dibutyryl cyclic AMP (300 micrograms/kg X min) produced significant and reversible increases in renin secretion rate, renal blood flow and urinary Na+ excretion.	Bucladesine	0-20	renin	Canis lupus familiaris	96-101
6397539-0	1984	Determination of role of sympathetic and renin-angiotensin systems in Goldblatt hypertension with urapidil and captopril.	urapidil	98-106	renin	Canis lupus familiaris	41-46
6092626-3	1984	In the non-filtering kidneys, dibutyryl cyclic AMP increased renin secretion rate and renal blood flow.	Cyclic AMP	40-50	renin	Canis lupus familiaris	61-66
6397539-0	1984	Determination of role of sympathetic and renin-angiotensin systems in Goldblatt hypertension with urapidil and captopril.	Captopril	111-120	renin	Canis lupus familiaris	41-46
6090839-0	1984	Prostacyclin-independence in beta-adrenoceptor mediated renin release from dog renal cortical slices.	Epoprostenol	0-12	renin	Canis lupus familiaris	56-61
6397539-8	1984	Urapidil increased plasma renin activity in the normotensives, but not in the hypertensives, whereas heart rate was increased and renal vascular resistance was decreased in both groups.	urapidil	0-8	renin	Canis lupus familiaris	26-31
6092626-4	1984	In indomethacin-treated dogs, dibutyryl cyclic AMP also produced significant and reversible increases in renin secretion rate and renal blood flow but had no effect on Na+ excretion.	Indomethacin	3-15	renin	Canis lupus familiaris	105-110
6090839-4	1984	These results indicate that the beta-adrenoceptor mediated renin release does not depend on the formation of PGI2, but renin release is dependent on cyclic AMP formation.	Cyclic AMP	149-159	renin	Canis lupus familiaris	119-124
6092626-4	1984	In indomethacin-treated dogs, dibutyryl cyclic AMP also produced significant and reversible increases in renin secretion rate and renal blood flow but had no effect on Na+ excretion.	Bucladesine	30-50	renin	Canis lupus familiaris	105-110
6092626-6	1984	These findings suggest that the effect of dibutyryl cyclic AMP on renin release is not mediated by prostaglandins or intracellular Ca and does not involve the macula densa.	Bucladesine	42-62	renin	Canis lupus familiaris	66-71
6149735-1	1984	Effects of K-351 (3,4-dihydro-8-(2-hydroxy-3-isopropyl-aminopropoxy)-3-nitroxy++ +-2H-1-benzopyran) on hemodynamics and renin release were investigated in pentobarbital anesthetized dogs.	nipradilol	11-16	renin	Canis lupus familiaris	120-125
6392654-2	1984	Pretreatment of dogs with captopril increased plasma renin activity, but it did not affect systemic blood pressure, renal blood flow and renal vascular resistance.	Captopril	26-35	renin	Canis lupus familiaris	53-58
6392654-3	1984	Acute blood volume expansion with saline suppressed plasma renin activity in dogs with or without pretreatment with captopril.	Sodium Chloride	34-40	renin	Canis lupus familiaris	59-64
6089583-7	1984	We conclude that PA response to intracerebroventricular ANG II is mediated primarily through the renin-angiotensin system in the salt-depleted state; however, in the salt-replete state, ACTH assumes a more important role.	Protactinium	17-19	renin	Canis lupus familiaris	97-102
6375362-1	1984	The inhibition of the renin-angiotensin system by captopril was used in pentobarbital-anesthetized dogs to confirm that the vasoconstrictive action of endorenally synthesized angiotensin II predominates on the efferent glomerular arteriole.	Captopril	50-59	renin	Canis lupus familiaris	22-27
6087679-0	1984	Antagonistic effect of theophylline on the adenosine-induced decreased in renin release.	Theophylline	23-35	renin	Canis lupus familiaris	74-79
6087679-0	1984	Antagonistic effect of theophylline on the adenosine-induced decreased in renin release.	Adenosine	43-52	renin	Canis lupus familiaris	74-79
6087679-1	1984	The action of theophylline on the adenosine-induced decrease in renin release was studied in anesthetized dogs.	Theophylline	14-26	renin	Canis lupus familiaris	64-69
6087679-1	1984	The action of theophylline on the adenosine-induced decrease in renin release was studied in anesthetized dogs.	Adenosine	34-43	renin	Canis lupus familiaris	64-69
6087679-2	1984	Adenosine inhibited renin release, decreased GFR and fractional sodium excretion, and decreased the concentration of angiotensin II in the renal lymph.	Adenosine	0-9	renin	Canis lupus familiaris	20-25
6087679-3	1984	Theophylline (5 mumol/min intrarenally) had no significant effect on GFR or RBF yet produced a significant increase in the release of renin and the fractional excretion of sodium.	Theophylline	0-12	renin	Canis lupus familiaris	134-139
6087679-4	1984	The intrarenal infusion of adenosine (3 X 10(-7) mol/min) during theophylline infusion produced no effect on GFR or RBF, but fractional sodium excretion and renin release were significantly decreased.	Adenosine	27-36	renin	Canis lupus familiaris	157-162
6087679-7	1984	Theophylline at 5 X 10(-6) mol/min, which stimulates renin release and effectively antagonizes the renal effects of adenosine, had no detectable effect on cAMP measured in renal cortex.	Theophylline	0-12	renin	Canis lupus familiaris	53-58
6087679-9	1984	These findings demonstrate that theophylline, at concentrations having no effect on cortical cAMP, antagonizes the effect of adenosine on renin release.	Theophylline	32-44	renin	Canis lupus familiaris	138-143
6087679-9	1984	These findings demonstrate that theophylline, at concentrations having no effect on cortical cAMP, antagonizes the effect of adenosine on renin release.	Adenosine	125-134	renin	Canis lupus familiaris	138-143
6087679-10	1984	The results are also consistent with the view that theophylline stimulates renin release by a mechanism other than its action on cAMP.	Theophylline	51-63	renin	Canis lupus familiaris	75-80
6382924-0	1984	Relationship between PGE2 and renin release in dog kidneys.	Dinoprostone	21-25	renin	Canis lupus familiaris	30-35
6382924-3	1984	This condition is known to increase renin release and enhance the stimulatory effects on renin release of beta-adrenergic agonists, such as isoproterenol.	Isoproterenol	140-153	renin	Canis lupus familiaris	89-94
6382924-5	1984	Isoproterenol infusion during afferent arteriolar dilation increased renin release but not PGE2 release both before and after indomethacin administration.	Isoproterenol	0-13	renin	Canis lupus familiaris	69-74
6382924-6	1984	Phenylephrine, an alpha-adrenergic agonist, which also induces afferent arteriolar dilation, increased PGE2 and renin release at control blood pressure but not when the afferent arterioles already were dilated by ureteral occlusion.	Phenylephrine	0-13	renin	Canis lupus familiaris	112-117
6382924-7	1984	We conclude that afferent arteriolar dilation caused by renal arterial constriction, ureteral occlusion or infusion of phenylephrine increases prostaglandin synthesis which stimulates renin release.	Phenylephrine	119-132	renin	Canis lupus familiaris	184-189
6382924-7	1984	We conclude that afferent arteriolar dilation caused by renal arterial constriction, ureteral occlusion or infusion of phenylephrine increases prostaglandin synthesis which stimulates renin release.	Prostaglandins	143-156	renin	Canis lupus familiaris	184-189
6382924-8	1984	The effect of isoproterenol on renin release is independent of prostaglandin synthesis.	Isoproterenol	14-27	renin	Canis lupus familiaris	31-36
6206324-0	1984	In vivo comparison of the renin inhibitor H77 with the angiotensin-converting enzyme inhibitor captopril.	H 77	42-45	renin	Canis lupus familiaris	26-31
6206324-3	1984	The slopes and intercepts were similar for the two inhibitors, suggesting that both H77 and captopril were operating predominantly via inhibition of the renin-angiotensin system.	Captopril	92-101	renin	Canis lupus familiaris	153-158
27785998-1	1984	The renin-angiotensin system (RAS) is suppressed either by high sodium intake or by high levels of angiotensin II (A II).	Sodium	64-70	renin	Canis lupus familiaris	4-9
27785998-9	1984	Plasma renin activity increased in all groups after CEI; however, renin secretion was suppressed by much smaller rates of angiotensin II infusion in the normal and sodium loaded dogs than in the sodium depleted dogs.	Sodium	164-170	renin	Canis lupus familiaris	66-71
27785998-9	1984	Plasma renin activity increased in all groups after CEI; however, renin secretion was suppressed by much smaller rates of angiotensin II infusion in the normal and sodium loaded dogs than in the sodium depleted dogs.	Sodium	195-201	renin	Canis lupus familiaris	66-71
27785998-12	1984	Also A II infusion and high dietary sodium can have independent effects on both plasma renin activity and plasma aldosterone concentration.	Sodium	36-42	renin	Canis lupus familiaris	87-92
6376345-0	1984	Effects of sodium depletion on inactive and active renin from dog kidney and plasma.	Sodium	11-17	renin	Canis lupus familiaris	51-56
6376345-1	1984	The relationship of active renin and inactive renin (trypsin-activated angiotensin-I-forming enzyme) to sodium depletion was examined in renal and peripheral plasma and at the subcellular level in the kidneys of dogs.	Sodium	104-110	renin	Canis lupus familiaris	46-51
6376345-6	1984	Sodium depletion also caused a 20-fold increase in active renin and a twofold increase in inactive renin in peripheral plasma.	Sodium	0-6	renin	Canis lupus familiaris	58-63
6376345-6	1984	Sodium depletion also caused a 20-fold increase in active renin and a twofold increase in inactive renin in peripheral plasma.	Sodium	0-6	renin	Canis lupus familiaris	99-104
6376345-7	1984	The renal venous-arterial concentration difference of inactive renin was statistically significant in low-sodium dogs, although it was not significant in controls.	Sodium	106-112	renin	Canis lupus familiaris	63-68
6376345-8	1984	The ratio of inactive to active renin was 0.2 to 0.4 in plasma from low-sodium dogs, while it was 1.5 to 3 in plasma from control dogs.	Sodium	72-78	renin	Canis lupus familiaris	32-37
6372522-7	1984	RNS at 0.075 Hz to one kidney and 0.7 Hz to the other kidney in the same dog demonstrated that the renin secretion rate was greater with RNS at 0.7 Hz than with 0.075 Hz at 50 and 90 mmHg but not at 130 and 170 mmHg.	Reactive Nitrogen Species	0-3	renin	Canis lupus familiaris	99-104
6372522-7	1984	RNS at 0.075 Hz to one kidney and 0.7 Hz to the other kidney in the same dog demonstrated that the renin secretion rate was greater with RNS at 0.7 Hz than with 0.075 Hz at 50 and 90 mmHg but not at 130 and 170 mmHg.	Reactive Nitrogen Species	137-140	renin	Canis lupus familiaris	99-104
6372523-0	1984	Circulating epinephrine stimulates renin secretion in anesthetized dogs by activation of extrarenal adrenoceptors.	Epinephrine	12-23	renin	Canis lupus familiaris	35-40
6372523-1	1984	The present experiments were designed to determine the location of the adrenoceptors responsible for initiating epinephrine-induced stimulation of renin secretion in vivo.	Epinephrine	112-123	renin	Canis lupus familiaris	147-152
6372523-4	1984	Intravenous infusion of epinephrine at 250 ng X kg-1 X min-1 increased one-kidney renin secretion rate more than fivefold.	Epinephrine	24-35	renin	Canis lupus familiaris	82-87
6372523-5	1984	In contrast, direct intrarenal infusion of epinephrine at 25 ng X kg-1 X min-1 only doubled renin secretion rate from the infused kidney.	Epinephrine	43-54	renin	Canis lupus familiaris	92-97
6372523-9	1984	At lower epinephrine infusion rates (10 ng X kg-1 X min-1 intravenously plus 3 ng X kg-1 X min-1 intrarenally), renin secretion rates increased submaximally but still equally from both kidneys.	Epinephrine	9-20	renin	Canis lupus familiaris	112-117
6372523-10	1984	It is concluded that epinephrine-induced stimulation of renin secretion in vivo is initiated by adrenoceptors located only extrarenally .	Epinephrine	21-32	renin	Canis lupus familiaris	56-61
6373590-0	1984	Statine-containing renin inhibitor.	statine	0-7	renin	Canis lupus familiaris	19-24
6323226-9	1984	These data indicate that the long-term hypotensive and natriuretic actions of inhibitors of ACE are mediated by inhibition of AngII formation and that the renin-angiotensin system plays an essential role in regulating aldosterone secretion, renal function, and AP during sodium deficiency.	Sodium	271-277	renin	Canis lupus familiaris	155-160
6200712-0	1984	Renin release induced by a nonvasoconstrictor dose of phenylephrine is independent of the renal prostaglandin system in anesthetized dogs.	Phenylephrine	54-67	renin	Canis lupus familiaris	0-5
6200712-1	1984	We examined the relationship between prostaglandin (PG) production and renin release induced by a nonvasoconstrictor dose of an alpha-agonist, phenylephrine, in anesthetized dogs.	Prostaglandins	37-50	renin	Canis lupus familiaris	71-76
6200712-1	1984	We examined the relationship between prostaglandin (PG) production and renin release induced by a nonvasoconstrictor dose of an alpha-agonist, phenylephrine, in anesthetized dogs.	Prostaglandins	52-54	renin	Canis lupus familiaris	71-76
6200712-1	1984	We examined the relationship between prostaglandin (PG) production and renin release induced by a nonvasoconstrictor dose of an alpha-agonist, phenylephrine, in anesthetized dogs.	Phenylephrine	143-156	renin	Canis lupus familiaris	71-76
6200712-2	1984	Intrarenal infusion of phenylephrine (1 microgram/min) did not affect systemic blood pressure or renal blood flow, but increased the renin secretion rate about twofold.	Phenylephrine	23-36	renin	Canis lupus familiaris	133-138
6200712-3	1984	The effect of phenylephrine on renin release was abolished by the intrarenal infusion of the alpha-antagonist phentolamine (50 micrograms/min), but was not affected by the intravenous administration of the PG synthetase inhibitor indomethacin (5 mg/kg).	Phenylephrine	14-27	renin	Canis lupus familiaris	31-36
6200712-3	1984	The effect of phenylephrine on renin release was abolished by the intrarenal infusion of the alpha-antagonist phentolamine (50 micrograms/min), but was not affected by the intravenous administration of the PG synthetase inhibitor indomethacin (5 mg/kg).	Phentolamine	110-122	renin	Canis lupus familiaris	31-36
6200712-3	1984	The effect of phenylephrine on renin release was abolished by the intrarenal infusion of the alpha-antagonist phentolamine (50 micrograms/min), but was not affected by the intravenous administration of the PG synthetase inhibitor indomethacin (5 mg/kg).	Indomethacin	230-242	renin	Canis lupus familiaris	31-36
6376907-6	1984	These three doses of AA also evoked proportional increments in the release of renin which were significantly correlated with the increases in 6-keto-PGF1 alpha.	6-Ketoprostaglandin F1 alpha	142-159	renin	Canis lupus familiaris	78-83
6376907-11	1984	However, renin release was significantly higher in SP than in JM glomeruli and correlated with 6-keto-PGF1 alpha synthesis.	sp	51-53	renin	Canis lupus familiaris	9-14
6325667-0	1984	Evidence for prostaglandin-independent mechanisms in renin release mediated by alpha adrenoceptors during renal nerve stimulation in anesthetized dogs.	Prostaglandins	13-26	renin	Canis lupus familiaris	53-58
6325667-2	1984	The effects of intrarenally infused phentolamine (5 micrograms/kg/min) on renin and prostaglandin E2 release induced by renal nerve stimulation (RNS, 2.5-5 Hz) were studied in indomethacin (5 mg/kg i.v.	Phentolamine	36-48	renin	Canis lupus familiaris	74-79
6325667-5	1984	Phentolamine inhibited the blood flow response and attenuated the renin response; it did not affect the prostaglandin E2 response.	Phentolamine	0-12	renin	Canis lupus familiaris	66-71
6325667-6	1984	In the indomethacin-treated group, the renal venous plasma prostaglandin E2 concentration was not changed, the renin secretion rate was increased during RNS.	Indomethacin	7-19	renin	Canis lupus familiaris	111-116
6325667-7	1984	Phentolamine also attenuated the renin response in this prostaglandin-depleted state.	Phentolamine	0-12	renin	Canis lupus familiaris	33-38
6325667-7	1984	Phentolamine also attenuated the renin response in this prostaglandin-depleted state.	Prostaglandins	56-69	renin	Canis lupus familiaris	33-38
6323885-2	1984	However relevant data from clinical studies are contradictory probably because spironolactone action on the kidneys also activates other mechanisms, such as renin secretion and potassium retention, which are potent stimulants of the adrenal cortex and thus tend to compensate for the inhibition.	Spironolactone	79-93	renin	Canis lupus familiaris	157-162
6373590-1	1984	Dissociation of blood pressure lowering and renin inhibition in sodium-deficient dogs.	Sodium	64-70	renin	Canis lupus familiaris	44-49
6319279-5	1984	Acute blockade of the renin-angiotensin system with captopril or saralasin produced the expected changes in blood pressure, PRA, and plasma AII concentration but did not decrease plasma vasopressin or corticosteroid concentrations.	Captopril	52-61	renin	Canis lupus familiaris	22-27
6364833-2	1984	The purpose of this study was to determine the role of the prostaglandin (PG) and adrenergic pathways in the renin release with exercise in the dog.	Prostaglandins	59-72	renin	Canis lupus familiaris	109-114
6364833-2	1984	The purpose of this study was to determine the role of the prostaglandin (PG) and adrenergic pathways in the renin release with exercise in the dog.	Prostaglandins	74-76	renin	Canis lupus familiaris	109-114
6437780-2	1984	In rats, dogs, and monkeys with 2-kidney renal hypertension, orally administered captopril rapidly and markedly reduces blood pressure; this antihypertensive effect apparently occurs via a renin-dependent mechanism; that is, the inhibition of ACE.	Captopril	81-90	renin	Canis lupus familiaris	189-194
6437780-3	1984	In 1-kidney renal hypertension studies in rats and dogs, it was determined that oral doses of captopril markedly lowered blood pressure, but only after several days of dosing; the mechanism is thought to be non-renin dependent.	Captopril	94-103	renin	Canis lupus familiaris	211-216
6696116-3	1984	Salt depletion induced a significant rise in plasma renin activity and aldosterone without potassium depletion.	Salts	0-4	renin	Canis lupus familiaris	52-57
6364150-0	1984	Cardiovascular and renin responses to vanadate in the conscious dog: attenuation after calcium channel blockade.	Vanadates	38-46	renin	Canis lupus familiaris	19-24
6364150-4	1984	Vanadate significantly suppressed plasma renin activity, but plasma vasopressin was unchanged.	Vanadates	0-8	renin	Canis lupus familiaris	41-46
6364150-7	1984	Calcium channel blockade also prevented the vanadate-induced decrease in plasma renin activity.	Vanadates	44-52	renin	Canis lupus familiaris	80-85
6439011-1	1984	Studies were undertaken to extend previous observations of the interaction between calcium and parathormone on renin synthesis by the kidney.	Calcium	83-90	renin	Canis lupus familiaris	111-116
6439011-9	1984	The rise in PRA could occur without changes in blood pressure or volume, consistent with an interruption of the short feedback loop control of renin synthesis by calcium antagonism.	Calcium	162-169	renin	Canis lupus familiaris	143-148
6319279-5	1984	Acute blockade of the renin-angiotensin system with captopril or saralasin produced the expected changes in blood pressure, PRA, and plasma AII concentration but did not decrease plasma vasopressin or corticosteroid concentrations.	Saralasin	65-74	renin	Canis lupus familiaris	22-27
6399316-8	1984	Chronic intraventricular administration of renin, 0.15 units twice daily to awake instrumented dogs receiving saline as the drinking fluid, markedly increased the daily intake of saline and increased diastolic and systolic blood pressure without increasing heart rate or carotid, coronary or renal blood flow velocities.	Sodium Chloride	110-116	renin	Canis lupus familiaris	43-48
6207570-4	1984	Renal vein renin activity (RRA) inclined to decrease by aprotinin and increased from 17.8 to 47.2 ng/ml/h (278.2%) by captopril (p less than 0.05).	Captopril	118-127	renin	Canis lupus familiaris	11-16
6207570-7	1984	These results indicate that the inhibition of endogenous angiotensin made a preferential increase in CPF and suggest that the renin-angiotensin system plays a major role in the effect of captopril of the renal hemodynamic changes.	Captopril	187-196	renin	Canis lupus familiaris	126-131
6139275-1	1983	The relationship between renin release evoked by circulating beta-agonists and the renal prostaglandin (PG) system is incompletely defined.	Prostaglandins	89-107	renin	Canis lupus familiaris	25-30
6399309-6	1984	In control dogs, water deprivation increased plasma osmolality from 301 +/- 2 to 308 +/- 2 mosm/kg, plasma vasopressin from 2.0 +/- 0.3 to 6.8 +/- 1.3 pg/ml and plasma renin activity from 3.3 +/- 1.2 to 10.4 +/- 3.0 ng AI/ml/3 h and a natriuresis of 2 mEq of sodium/kg.	Water	17-22	renin	Canis lupus familiaris	168-173
6399316-8	1984	Chronic intraventricular administration of renin, 0.15 units twice daily to awake instrumented dogs receiving saline as the drinking fluid, markedly increased the daily intake of saline and increased diastolic and systolic blood pressure without increasing heart rate or carotid, coronary or renal blood flow velocities.	Sodium Chloride	179-185	renin	Canis lupus familiaris	43-48
6399316-9	1984	There appears to be a direct significant relationship between the increase in mean blood pressure due to the intraventricular administration of renin and the volume of saline consumed.	Sodium Chloride	168-174	renin	Canis lupus familiaris	144-149
6345700-5	1983	NaCl, 0.45M, did not affect renal function, whereas both 0.9M and 1.8M NaCl increased renal blood flow and urinary sodium excretion; neither 0.45M, 0.9M, nor 1.8M NaCl affected renin secretion rate.	Sodium Chloride	71-75	renin	Canis lupus familiaris	177-182
6367910-1	1983	Chronic potassium deficiency in one-kidney one-clip hypertensive dogs significantly reduces blood pressure and plasma potassium, with a simultaneous increase in plasma renin activity.	Potassium	8-17	renin	Canis lupus familiaris	168-173
12002592-7	1983	It was concluded that heart failure in the dog increases PAC, most likely because of renin-angiotensin-aldosterone-system activation, and that the increase is related directly to the clinical status of the patient.	pac	57-60	renin	Canis lupus familiaris	85-90
6353937-2	1983	Verapamil infusion (0.004 mg X kg-1 X min-1) into the renal artery of uninephrectomized dogs with an intact kidney resulted in significant increases (P less than 0.05) in renal blood flow, creatinine clearance, and the excreted fractions of Na+ and Cl-; renin secretion decreased (P less than 0.05) and plasma aldosterone did not change.	Verapamil	0-9	renin	Canis lupus familiaris	254-259
6353937-3	1983	Conversely, renal arterial infusion of verapamil in dogs with nonfiltering, denervated, papaverine-treated kidneys resulted in no change in renal blood flow and a significant increase (P less than 0.05) in renin secretion.	Verapamil	39-48	renin	Canis lupus familiaris	206-211
6353937-3	1983	Conversely, renal arterial infusion of verapamil in dogs with nonfiltering, denervated, papaverine-treated kidneys resulted in no change in renal blood flow and a significant increase (P less than 0.05) in renin secretion.	Papaverine	88-98	renin	Canis lupus familiaris	206-211
6353937-7	1983	The disparate effects of verapamil on renin secretion from intact and nonfiltering kidneys may be due to actions of the Ca2+ channel blocker on renal hemodynamic and/or renal tubular mechanisms in the intact kidney that mask a direct effect of verapamil on renin-secreting cells.	Verapamil	25-34	renin	Canis lupus familiaris	38-43
6353940-9	1983	It is concluded that portal hypertension, but not a "sick liver per se, in cirrhosis activates the renin-angiotensin system to both produce renal vasoconstriction and stimulate prostaglandin synthesis, thereby normalizing renal perfusion.	Prostaglandins	177-190	renin	Canis lupus familiaris	99-104
6353943-1	1983	Chronic sodium depletion is a state of reduced cardiac output in which the renin-angiotensin system is actively involved in maintenance of mean arterial blood pressure (MAP).	Sodium	8-14	renin	Canis lupus familiaris	75-80
6353944-3	1983	However, plasma renin activity (PRA) was 11-fold higher in sodium-deplete dogs (P less than 0.01).	Sodium	59-65	renin	Canis lupus familiaris	16-21
6368210-2	1983	Intravenous injection of acebutolol into anesthetized dogs almost doubled the plasma adrenaline and noradrenaline concentrations within 5 to 15 minutes, while renin activity was reduced to approximately two-thirds of the pre-administration level.	Acebutolol	25-35	renin	Canis lupus familiaris	159-164
6141075-13	1983	The present data also suggested that both furosemide and prostaglandins stimulated aldosterone secretion via the renin-angiotensin system, rather than by acting directly on the adrenal cortex.	Furosemide	42-52	renin	Canis lupus familiaris	113-118
6141075-13	1983	The present data also suggested that both furosemide and prostaglandins stimulated aldosterone secretion via the renin-angiotensin system, rather than by acting directly on the adrenal cortex.	Prostaglandins	57-71	renin	Canis lupus familiaris	113-118
6349389-1	1983	The effects of inhibition of the renin-angiotensin system on the decreased renal excretion of sodium and water resulting from behavioral stress (shock avoidance) were examined in conscious saline-infused (4-5 ml/min) dogs.	Sodium	94-100	renin	Canis lupus familiaris	33-38
6349389-6	1983	These mean changes in excretion during inhibition of the renin-angiotensin system were significantly (P less than 0.05) less than during saline alone.	Sodium Chloride	137-143	renin	Canis lupus familiaris	57-62
6349389-7	1983	Whereas decreases in fractional sodium and water excretion were attenuated by renin-angiotensin inhibition, decreases in glomerular filtration rate and effective renal blood flow and increases in mean arterial pressure were not affected.	Sodium	32-38	renin	Canis lupus familiaris	78-83
6345047-7	1983	Immunoaffinity chromatography with renin-specific antibodies coupled to Sepharose provided a simple and specific method for isolation of high-molecular-weight renin.	Sepharose	72-81	renin	Canis lupus familiaris	159-164
6345700-5	1983	NaCl, 0.45M, did not affect renal function, whereas both 0.9M and 1.8M NaCl increased renal blood flow and urinary sodium excretion; neither 0.45M, 0.9M, nor 1.8M NaCl affected renin secretion rate.	Sodium Chloride	71-75	renin	Canis lupus familiaris	177-182
6345700-10	1983	infusion of 0.9M NaCl increased urinary sodium excretion and reduced the renin secretion rate response to LFRNS (-52% +/- 15, p less than 0.02) and HFRNS (-25% +/- 8, p less than 0.01).	Sodium Chloride	17-21	renin	Canis lupus familiaris	73-78
6346900-0	1983	Alteration of renal baroreceptor by salt intake in control of plasma renin activity in conscious dogs.	Salts	36-40	renin	Canis lupus familiaris	69-74
6413220-2	1983	In normal conscious dogs, a 60-min nitroprusside infusion increased plasma renin activity from 1.05 +/- 0.26 to 8.35 +/- 1.20 ng, angiotensin I ml-1 h-1 (P less than 0.002) and heart rate from 83 +/- 6 to 149 +/- 15 beats/min (P less than 0.002).	Nitroprusside	35-48	renin	Canis lupus familiaris	75-80
6413220-5	1983	Plasma renin activity also increased acutely after hydralazine administration in dogs which myocardial infarction (1.05 +/- 0.26 to 8.99 +/- 0.79 ng ml-1 h-1; P less than 0.05); after 1 week of hydralazine, plasma volume had increased from 54.9 +/- 0.9 ml kg-1 to 74.5 +/- 4.9 ml kg-1 (P less than 0.05) and plasma renin activity remained higher than control (4.66 +/- 0.66 ng ml-1 h-1; P less than 0.01).	Hydralazine	51-62	renin	Canis lupus familiaris	7-12
6413220-5	1983	Plasma renin activity also increased acutely after hydralazine administration in dogs which myocardial infarction (1.05 +/- 0.26 to 8.99 +/- 0.79 ng ml-1 h-1; P less than 0.05); after 1 week of hydralazine, plasma volume had increased from 54.9 +/- 0.9 ml kg-1 to 74.5 +/- 4.9 ml kg-1 (P less than 0.05) and plasma renin activity remained higher than control (4.66 +/- 0.66 ng ml-1 h-1; P less than 0.01).	Hydralazine	51-62	renin	Canis lupus familiaris	315-320
6413220-5	1983	Plasma renin activity also increased acutely after hydralazine administration in dogs which myocardial infarction (1.05 +/- 0.26 to 8.99 +/- 0.79 ng ml-1 h-1; P less than 0.05); after 1 week of hydralazine, plasma volume had increased from 54.9 +/- 0.9 ml kg-1 to 74.5 +/- 4.9 ml kg-1 (P less than 0.05) and plasma renin activity remained higher than control (4.66 +/- 0.66 ng ml-1 h-1; P less than 0.01).	Hydralazine	194-205	renin	Canis lupus familiaris	7-12
6351206-7	1983	Plasma renin activity was markedly elevated and further increased in the sodium-deplete group, but it was nearly unchanged in the sodium-replete group.	Sodium	73-79	renin	Canis lupus familiaris	7-12
6351206-8	1983	This difference in renal response to exogenous PGA1 might be due to interaction with the renin-angiotensin system, which was markedly stimulated by sodium depletion and additionally by prostaglandin infusion.	prostaglandin A1	47-51	renin	Canis lupus familiaris	89-94
6351206-8	1983	This difference in renal response to exogenous PGA1 might be due to interaction with the renin-angiotensin system, which was markedly stimulated by sodium depletion and additionally by prostaglandin infusion.	Sodium	148-154	renin	Canis lupus familiaris	89-94
6190801-5	1983	Renin was then hydrolyzed slowly to give two chains of Mr = 33,000 and 5,000 held together by disulfide bonds.	Disulfides	94-103	renin	Canis lupus familiaris	0-5
6405027-2	1983	The clearance of renin was 0.61 +/- 0.19 ml/min in control experiments and increased significantly to 1.26 +/- 0.38 ml/min after furosemide.	Furosemide	129-139	renin	Canis lupus familiaris	17-22
6351206-8	1983	This difference in renal response to exogenous PGA1 might be due to interaction with the renin-angiotensin system, which was markedly stimulated by sodium depletion and additionally by prostaglandin infusion.	Prostaglandins	185-198	renin	Canis lupus familiaris	89-94
6413735-0	1983	Effects of EDTA and verapamil on renin release in dogs.	Edetic Acid	11-15	renin	Canis lupus familiaris	33-38
6413735-0	1983	Effects of EDTA and verapamil on renin release in dogs.	Verapamil	20-29	renin	Canis lupus familiaris	33-38
6413735-1	1983	EDTA or verapamil was infused into the renal artery of the anesthetized dog, and the effects on renin release and renal function were examined in an attempt to elucidate the role and action site of calcium ion in the renin secretory system.	Edetic Acid	0-4	renin	Canis lupus familiaris	217-222
6413735-1	1983	EDTA or verapamil was infused into the renal artery of the anesthetized dog, and the effects on renin release and renal function were examined in an attempt to elucidate the role and action site of calcium ion in the renin secretory system.	Calcium	198-205	renin	Canis lupus familiaris	217-222
6413735-6	1983	Therefore, the effects of EDTA and verapamil on renin release may reflect the action of both drugs on the vascular component of the juxtaglomerular apparatus.	Edetic Acid	26-30	renin	Canis lupus familiaris	48-53
6413735-6	1983	Therefore, the effects of EDTA and verapamil on renin release may reflect the action of both drugs on the vascular component of the juxtaglomerular apparatus.	Verapamil	35-44	renin	Canis lupus familiaris	48-53
6413735-7	1983	If a change in calcium movement similar to the one in vascular smooth muscle occurs in the juxtaglomerular cells, the altered concentration of calcium may be considered to induce, in part, the stimulation of renin release by EDTA or verapamil.	Calcium	15-22	renin	Canis lupus familiaris	208-213
6413735-7	1983	If a change in calcium movement similar to the one in vascular smooth muscle occurs in the juxtaglomerular cells, the altered concentration of calcium may be considered to induce, in part, the stimulation of renin release by EDTA or verapamil.	Calcium	143-150	renin	Canis lupus familiaris	208-213
6413735-7	1983	If a change in calcium movement similar to the one in vascular smooth muscle occurs in the juxtaglomerular cells, the altered concentration of calcium may be considered to induce, in part, the stimulation of renin release by EDTA or verapamil.	Edetic Acid	225-229	renin	Canis lupus familiaris	208-213
6413735-7	1983	If a change in calcium movement similar to the one in vascular smooth muscle occurs in the juxtaglomerular cells, the altered concentration of calcium may be considered to induce, in part, the stimulation of renin release by EDTA or verapamil.	Verapamil	233-242	renin	Canis lupus familiaris	208-213
6223680-1	1983	1 The effect of intrarenal histamine, dimaprit (H2-agonist) and 2-(2-pyridyl) ethylamine (H1-agonist) on renin release was examined in anaesthetized dogs.	2-(2-aminoethyl)pyridine	64-88	renin	Canis lupus familiaris	105-110
6223680-3	1983	2(2-Pyridyl) ethylamine administration resulted in renal vasodilatation, a 25% decrease in urinary sodium excretion and a significant increase in renin release.	2-(2-aminoethyl)pyridine	0-23	renin	Canis lupus familiaris	146-151
6223680-4	1983	3 In dogs with non-filtering kidneys, dimaprit administration resulted in renal vasodilatation and a significant increase in renin release, while 2(2-pyridyl) ethylamine administration resulted in renal vasodilatation but no change in renin release.	Dimaprit	38-46	renin	Canis lupus familiaris	125-130
6341216-3	1983	On a regular sodium intake, healthy conscious dogs apparently have a much lower plasma renin activity (PRA) than healthy human volunteers.	Sodium	13-19	renin	Canis lupus familiaris	87-92
6341216-8	1983	The posttryptic increase in PRA is evident whether plasma incubation is carried out at pH 6.0 or at 7.4, and can be largely blocked by pepstatin, which also implicates a prorenin-renin mechanism rather than TDP-cathepsin.	pepstatin	135-144	renin	Canis lupus familiaris	173-178
6341218-2	1983	In canine neonatally-induced coarctation hypertension, we reported abnormally elevated plasma renin activity (PRA) during sodium restriction in 2-year-old dogs, but found normal PRA responses to sodium restriction +/- furosemide in coarcted dogs studied serially over the first year postaortic banding (PAB).	Sodium	122-128	renin	Canis lupus familiaris	94-99
6344091-4	1983	Renin secretion increased significantly during application of CPPV with a positive and expiratory pressure of 10 cm water in the dogs of the intact group but was not altered in dogs of the denervated group.	Water	116-121	renin	Canis lupus familiaris	0-5
6405027-3	1983	The fractional excretion of renin increased from 1.51 +/- 0.45% during control to 3.90 +/- 0.98% after furosemide.	Furosemide	103-113	renin	Canis lupus familiaris	28-33
6405027-4	1983	The rate of excretion of renin was increased 10-fold during furosemide diuresis associated with a 10-fold increase in plasma renin concentration.	Furosemide	60-70	renin	Canis lupus familiaris	25-30
6187227-2	1983	Although the fall in blood pressure and the increase in heart rate were similar in the two salt states, the salt-restricted animals had significantly greater rises in plasma renin activity and plasma catecholamines following hemorrhage than did the normal salt dogs.	Salts	108-112	renin	Canis lupus familiaris	174-179
6397510-6	1983	Mean plasma concentrations of renin, angiotensin II and aldosterone tended to be lower during prolonged infusion of noradrenaline, but only the fall of renin during the second week was significant in one group of dogs.	Norepinephrine	116-129	renin	Canis lupus familiaris	30-35
6397510-7	1983	Noradrenaline at higher rates significantly raised blood pressure and increased plasma concentrations of renin and angiotensin II.	Norepinephrine	0-13	renin	Canis lupus familiaris	105-129
6301285-0	1983	Interaction of renal beta 1-adrenoceptors and prostaglandins in reflex renin release.	Prostaglandins	46-60	renin	Canis lupus familiaris	71-76
6301285-3	1983	Metoprolol, a beta 1-adrenoceptor antagonist, given in the renal artery, did not affect the decrease in urinary sodium excretion but attenuated the increase in renin secretion rate, from 1,764 +/- 525 to 412 +/- 126 ng/min (70 +/- 8%).	Metoprolol	0-10	renin	Canis lupus familiaris	160-165
6301285-4	1983	Indomethacin or meclofenamate, prostaglandin synthesis inhibitors, did not affect the decrease in urinary sodium excretion but attenuated the increase in renin secretion rate, from 1,523 +/- 416 to 866 +/- 413 ng/min (51 +/- 18%).	Indomethacin	0-12	renin	Canis lupus familiaris	154-159
6301285-4	1983	Indomethacin or meclofenamate, prostaglandin synthesis inhibitors, did not affect the decrease in urinary sodium excretion but attenuated the increase in renin secretion rate, from 1,523 +/- 416 to 866 +/- 413 ng/min (51 +/- 18%).	Meclofenamic Acid	16-29	renin	Canis lupus familiaris	154-159
6301285-5	1983	Addition of metoprolol to indomethacin-pretreated dogs attenuated the increase in renin secretion rate from 833 +/- 327 to 94 +/- 60 ng/min (86 +/- 10%).	Metoprolol	12-22	renin	Canis lupus familiaris	82-87
6301285-5	1983	Addition of metoprolol to indomethacin-pretreated dogs attenuated the increase in renin secretion rate from 833 +/- 327 to 94 +/- 60 ng/min (86 +/- 10%).	Indomethacin	26-38	renin	Canis lupus familiaris	82-87
6301285-6	1983	These results indicate that reflex RNS at constant renal perfusion pressure results in an increase in renin secretion rate that is largely mediated by renal beta 1-adrenoceptors and is partly dependent on intact renal prostaglandin synthesis.	Reactive Nitrogen Species	35-38	renin	Canis lupus familiaris	102-107
6301285-6	1983	These results indicate that reflex RNS at constant renal perfusion pressure results in an increase in renin secretion rate that is largely mediated by renal beta 1-adrenoceptors and is partly dependent on intact renal prostaglandin synthesis.	Prostaglandins	218-231	renin	Canis lupus familiaris	102-107
6187227-4	1983	These latter experiments demonstrated that salt restriction resulted in a significantly greater role for the renin-angiotensin system.	Salts	43-47	renin	Canis lupus familiaris	109-114
6347175-0	1983	The effect of repeated intravenous and oral doses of molsidomine (N-carboxy-3-morpholino-sydnonimine-ethylester) on plasma renin activity and plasma catecholamine levels in conscious dogs.	Molsidomine	53-64	renin	Canis lupus familiaris	123-128
6347175-0	1983	The effect of repeated intravenous and oral doses of molsidomine (N-carboxy-3-morpholino-sydnonimine-ethylester) on plasma renin activity and plasma catecholamine levels in conscious dogs.	Molsidomine	66-111	renin	Canis lupus familiaris	123-128
6187227-5	1983	Moreover, interruption of the renin-angiotensin system blunted the anticipated rise in catecholamines and heart rate during the additional hypotension induced by converting enzyme blockade after hemorrhage.	Catecholamines	87-101	renin	Canis lupus familiaris	30-35
6298402-0	1983	Catecholamine-induced renin release in the anesthetized mongrel dog is due to both alpha and beta adrenoceptor stimulation: evidence that only the alpha adrenoceptor component is prostaglandin mediated.	Catecholamines	0-13	renin	Canis lupus familiaris	22-27
6347479-0	1983	Effects of a non-vasoconstrictor dose of phenylephrine on prostaglandin E2 and renin release in anaesthetized dogs.	Phenylephrine	41-54	renin	Canis lupus familiaris	72-84
6347479-6	1983	However, both prostaglandin E2 and renin secretion rates were increased by the infusion of phenylephrine.	Phenylephrine	91-104	renin	Canis lupus familiaris	35-40
6343273-0	1983	Effects of exogenous inactive renin on blood pressure and adrenal secretion of aldosterone and cortisol in the canine puppy.	Aldosterone	79-90	renin	Canis lupus familiaris	30-35
6343273-0	1983	Effects of exogenous inactive renin on blood pressure and adrenal secretion of aldosterone and cortisol in the canine puppy.	Hydrocortisone	95-103	renin	Canis lupus familiaris	30-35
6345452-0	1983	Relationship of renal hemodynamic and functional changes following intravascular contrast to the renin-angiotensin system and renal prostacyclin in the dog.	Epoprostenol	132-144	renin	Canis lupus familiaris	97-102
6338138-9	1983	We conclude that (1) sodium depletion accentuates both the magnitude and duration of the vasoconstrictive phase of the renal blood flow response to injection of contrast medium and (2) blockade of the intrarenal renin-angiotensin system shortens the duration of this response.	Sodium	21-27	renin	Canis lupus familiaris	212-217
6298402-1	1983	The role of renal alpha and beta adrenoceptor activation and prostaglandin synthesis in mediating renin release to intrarenal infusions of the natural neurotransmitters, norepinephrine and epinephrine, was assessed in anesthetized mongrel dogs.	Prostaglandins	61-74	renin	Canis lupus familiaris	98-103
6298402-2	1983	Intrarenal infusions of norepinephrine and epinephrine at doses adjusted to reduce renal blood flow by 20 and 50% of baseline values elicited renin release that was not completely blocked by either alpha adrenoceptor blockade with phentolamine or beta adrenoceptor blockade with propranolol.	Norepinephrine	24-38	renin	Canis lupus familiaris	142-147
6298402-2	1983	Intrarenal infusions of norepinephrine and epinephrine at doses adjusted to reduce renal blood flow by 20 and 50% of baseline values elicited renin release that was not completely blocked by either alpha adrenoceptor blockade with phentolamine or beta adrenoceptor blockade with propranolol.	Epinephrine	27-38	renin	Canis lupus familiaris	142-147
6348252-4	1983	In contrast, indomethacin pre-treatment (2 X 2-3 mg kg-1 orally) significantly lessened the increase in plasma renin activity during reduced renal artery pressure (+ 2.0 +/- 0.3 ng ml.-1 hr-1, n = 11).	Indomethacin	13-25	renin	Canis lupus familiaris	111-116
6348252-9	1983	Thus the reduced renin release in response to lowered renal artery pressure in indomethacin pre-treated dogs may have been due to another, non-prostaglandin action of indomethacin.	Indomethacin	79-91	renin	Canis lupus familiaris	17-22
6298402-2	1983	Intrarenal infusions of norepinephrine and epinephrine at doses adjusted to reduce renal blood flow by 20 and 50% of baseline values elicited renin release that was not completely blocked by either alpha adrenoceptor blockade with phentolamine or beta adrenoceptor blockade with propranolol.	Phentolamine	231-243	renin	Canis lupus familiaris	142-147
6348252-9	1983	Thus the reduced renin release in response to lowered renal artery pressure in indomethacin pre-treated dogs may have been due to another, non-prostaglandin action of indomethacin.	Indomethacin	167-179	renin	Canis lupus familiaris	17-22
6298402-2	1983	Intrarenal infusions of norepinephrine and epinephrine at doses adjusted to reduce renal blood flow by 20 and 50% of baseline values elicited renin release that was not completely blocked by either alpha adrenoceptor blockade with phentolamine or beta adrenoceptor blockade with propranolol.	Propranolol	279-290	renin	Canis lupus familiaris	142-147
6298402-3	1983	The renin release that persisted during propranolol administration was abolished by the alpha adrenoceptor antagonist, phentolamine, and by the prostaglandin synthetase inhibitor, indomethacin.	Propranolol	40-51	renin	Canis lupus familiaris	4-9
6129946-1	1983	The location and nature of the receptors in the brain on which clonidine acts to decrease renin secretion have been investigated in dogs.	Clonidine	63-72	renin	Canis lupus familiaris	90-95
6336914-0	1983	Effect of intrarenal administration of dopamine on renin release in conscious dogs.	Dopamine	39-47	renin	Canis lupus familiaris	51-56
6348358-0	1983	Effects of pentobarbital anesthesia on the plasma catecholamines and renin activity as reflected in the hemodynamic changes in dogs.	Pentobarbital	11-24	renin	Canis lupus familiaris	69-74
6312554-0	1983	Conditions for augmentation of renin release by theophylline.	Theophylline	48-60	renin	Canis lupus familiaris	31-36
6312554-1	1983	Isoproterenol, dopamine, glucagon and dibutyryl cyclic AMP (DB-cAMP) increase renin release at low but not at control blood pressure.	Isoproterenol	0-13	renin	Canis lupus familiaris	78-83
6312554-1	1983	Isoproterenol, dopamine, glucagon and dibutyryl cyclic AMP (DB-cAMP) increase renin release at low but not at control blood pressure.	Dopamine	15-23	renin	Canis lupus familiaris	78-83
6312554-1	1983	Isoproterenol, dopamine, glucagon and dibutyryl cyclic AMP (DB-cAMP) increase renin release at low but not at control blood pressure.	Glucagon	25-33	renin	Canis lupus familiaris	78-83
6312554-1	1983	Isoproterenol, dopamine, glucagon and dibutyryl cyclic AMP (DB-cAMP) increase renin release at low but not at control blood pressure.	Bucladesine	38-58	renin	Canis lupus familiaris	78-83
6312554-1	1983	Isoproterenol, dopamine, glucagon and dibutyryl cyclic AMP (DB-cAMP) increase renin release at low but not at control blood pressure.	Bucladesine	60-67	renin	Canis lupus familiaris	78-83
6312554-2	1983	These findings suggest that autoregulated afferent arteriolar dilation is a prerequisite of renin release mediated by intracellular generation of cyclic AMP.	Cyclic AMP	146-156	renin	Canis lupus familiaris	92-97
6312554-3	1983	To examine this hypothesis further the effects on renin release of theophylline, which would maintain high intracellular concentration of cAMP by inhibiting phosphodiesterase, were studied in anesthetized dogs.	Theophylline	67-79	renin	Canis lupus familiaris	50-55
6312554-4	1983	After inhibiting beta-adrenergic stimulation with propranolol, theophylline increased renin release significantly from 0.7 +/- 0.2 to 1.8 +/- 0.7 micrograms/min at control blood pressure and from 23 +/- 4 to 41 +/- 5 micrograms/min at a renal perfusion pressure of about 50 mmHg.	Theophylline	63-75	renin	Canis lupus familiaris	86-91
6312554-6	1983	Isoproterenol infusion at low blood pressure raised renin release from 41 +/- 11 to 76 +/- 19 micrograms/min before and 54 +/- 13 to 108 +/- 31 micrograms/min during continuous infusion of theophylline.	Isoproterenol	0-13	renin	Canis lupus familiaris	52-57
6312554-7	1983	The renin release response to infusion of theophylline at low blood pressure was not enhanced by DB-cAMP infusion.	Theophylline	42-54	renin	Canis lupus familiaris	4-9
6312554-8	1983	We conclude that arteriolar dilation provides a condition for stimulation of renin release during the theophylline infusion.	Theophylline	102-114	renin	Canis lupus familiaris	77-82
6312554-9	1983	Theophylline infusion may augment the effect of isoproterenol on renin release by delaying the intracellular degradation of cAMP.	Theophylline	0-12	renin	Canis lupus familiaris	65-70
6312554-9	1983	Theophylline infusion may augment the effect of isoproterenol on renin release by delaying the intracellular degradation of cAMP.	Isoproterenol	48-61	renin	Canis lupus familiaris	65-70
6312554-9	1983	Theophylline infusion may augment the effect of isoproterenol on renin release by delaying the intracellular degradation of cAMP.	Cyclic AMP	124-128	renin	Canis lupus familiaris	65-70
6342558-0	1983	Role of renal prostaglandin in renin release during renal nerve stimulation in anesthetized dogs.	Prostaglandins	14-27	renin	Canis lupus familiaris	31-36
6342558-1	1983	The relationship of prostaglandin (PG) release to changes in renin release and renal blood flow (RBF) to renal nerve stimulation (RNS) was investigated in pentobarbital anesthetized dogs.	Prostaglandins	20-33	renin	Canis lupus familiaris	61-66
6342558-1	1983	The relationship of prostaglandin (PG) release to changes in renin release and renal blood flow (RBF) to renal nerve stimulation (RNS) was investigated in pentobarbital anesthetized dogs.	Prostaglandins	35-37	renin	Canis lupus familiaris	61-66
6342558-8	1983	Indomethacin also suppressed the increase in renin secretion rate.	Indomethacin	0-12	renin	Canis lupus familiaris	45-50
6342558-9	1983	These results suggest that the renin and RBF responses to RNS are modulated by concomitantly released PG.	Reactive Nitrogen Species	58-61	renin	Canis lupus familiaris	31-44
6342558-9	1983	These results suggest that the renin and RBF responses to RNS are modulated by concomitantly released PG.	Prostaglandins	102-104	renin	Canis lupus familiaris	31-44
6336914-1	1983	We investigated the effect of intrarenal administration of dopamine on renin release in conscious dogs.	Dopamine	59-67	renin	Canis lupus familiaris	71-76
6336914-6	1983	To determine if the dopamine-induced renin release is related to its vasodilatory action, two other vasodilators, papaverine and acetylcholine, were infused into the renal artery, but neither, in doses that produced a rise in renal blood flow similar to that of dopamine, had any effect on PRA.	Dopamine	20-28	renin	Canis lupus familiaris	37-42
6336914-8	1983	Intrarenal infusion of sulpiride and haloperidol, dopamine antagonists, significantly inhibited dopamine-induced renin release and renal vasodilatation.	Sulpiride	23-32	renin	Canis lupus familiaris	113-118
6336914-8	1983	Intrarenal infusion of sulpiride and haloperidol, dopamine antagonists, significantly inhibited dopamine-induced renin release and renal vasodilatation.	Haloperidol	37-48	renin	Canis lupus familiaris	113-118
6336914-8	1983	Intrarenal infusion of sulpiride and haloperidol, dopamine antagonists, significantly inhibited dopamine-induced renin release and renal vasodilatation.	Dopamine	50-58	renin	Canis lupus familiaris	113-118
6336914-8	1983	Intrarenal infusion of sulpiride and haloperidol, dopamine antagonists, significantly inhibited dopamine-induced renin release and renal vasodilatation.	Dopamine	96-104	renin	Canis lupus familiaris	113-118
6336914-10	1983	Simultaneous infusion of phentolamine and dopamine, on the other hand, produced a significant potentiation of dopamine-induced renin release and renal vasodilatation.	Phentolamine	25-37	renin	Canis lupus familiaris	127-132
6336914-10	1983	Simultaneous infusion of phentolamine and dopamine, on the other hand, produced a significant potentiation of dopamine-induced renin release and renal vasodilatation.	Dopamine	42-50	renin	Canis lupus familiaris	127-132
6336914-10	1983	Simultaneous infusion of phentolamine and dopamine, on the other hand, produced a significant potentiation of dopamine-induced renin release and renal vasodilatation.	Dopamine	110-118	renin	Canis lupus familiaris	127-132
6336914-11	1983	In conclusion, our studies demonstrate that dopamine is capable of inducing renin release and renal vasodilatation in conscious dogs.	Dopamine	44-52	renin	Canis lupus familiaris	76-81
6291915-0	1983	Plasma renin activity during infusion of epinephrine into the celiac and superior mesenteric arteries in dogs.	Epinephrine	41-52	renin	Canis lupus familiaris	7-12
6298402-3	1983	The renin release that persisted during propranolol administration was abolished by the alpha adrenoceptor antagonist, phentolamine, and by the prostaglandin synthetase inhibitor, indomethacin.	Phentolamine	119-131	renin	Canis lupus familiaris	4-9
6298402-3	1983	The renin release that persisted during propranolol administration was abolished by the alpha adrenoceptor antagonist, phentolamine, and by the prostaglandin synthetase inhibitor, indomethacin.	Indomethacin	180-192	renin	Canis lupus familiaris	4-9
6298402-4	1983	The beta adrenergic component of renin release, elicited in the presence of phentolamine, was not blocked by indomethacin but abolished by propranolol.	Phentolamine	76-88	renin	Canis lupus familiaris	33-38
6298402-4	1983	The beta adrenergic component of renin release, elicited in the presence of phentolamine, was not blocked by indomethacin but abolished by propranolol.	Propranolol	139-150	renin	Canis lupus familiaris	33-38
6298402-5	1983	These data are consistent with the hypothesis that norepinephrine and epinephrine stimulate renin release by activation of both the renal beta and renal alpha adrenoceptors.	Norepinephrine	51-65	renin	Canis lupus familiaris	92-97
6298402-5	1983	These data are consistent with the hypothesis that norepinephrine and epinephrine stimulate renin release by activation of both the renal beta and renal alpha adrenoceptors.	Epinephrine	54-65	renin	Canis lupus familiaris	92-97
6339771-5	1983	The administration of furosemide produced significant increases in plasma NE (142.4 +/- 23.7%, p less than 0.01), plasma renin activity (PRA) (158.6 +/- 26.3%, p less than 0.01) and HR (32.3 +/- 6.0 beats/min, p less than 0.01).	Furosemide	22-32	renin	Canis lupus familiaris	121-126
6293314-2	1982	Furosemide (2 mg/kg) induced significant diuresis, natriuresis, an increase in renal blood flow (RBF), and a fivefold increase in renin secretory rate (RSR), but no changes in glomerular filtration rate (GFR).	Furosemide	0-10	renin	Canis lupus familiaris	130-135
6759835-4	1982	Infusion of dTDAVP at 0.01 and 0.05 ng/kg/min suppressed plasma renin activity to 86 +/- 4% (p less than 0.05) and 63 +/- 6% (p less than 0.01) of the control values respectively.	dtdavp	12-18	renin	Canis lupus familiaris	64-69
6293314-11	1982	These results indicate that inhibition of renal Na+-K+-ATPase abolishes furosemide-induced renin secretion despite potentiation of the natriuretic effect of the diuretic.	Furosemide	72-82	renin	Canis lupus familiaris	91-96
7139885-8	1982	At the time papillary plasma flow was measured, extracellular fluid volume was similar among the four groups of dogs; however, plasma renin activity increased significantly in furosemide and ethacrynic acid dogs (P less than 0.01) and remained unchanged in normal and chlorothiazide dogs.	Furosemide	176-186	renin	Canis lupus familiaris	134-139
7139885-8	1982	At the time papillary plasma flow was measured, extracellular fluid volume was similar among the four groups of dogs; however, plasma renin activity increased significantly in furosemide and ethacrynic acid dogs (P less than 0.01) and remained unchanged in normal and chlorothiazide dogs.	Ethacrynic Acid	191-206	renin	Canis lupus familiaris	134-139
7139885-8	1982	At the time papillary plasma flow was measured, extracellular fluid volume was similar among the four groups of dogs; however, plasma renin activity increased significantly in furosemide and ethacrynic acid dogs (P less than 0.01) and remained unchanged in normal and chlorothiazide dogs.	Chlorothiazide	268-282	renin	Canis lupus familiaris	134-139
6129126-1	1982	To determine if alpha 1-or alpha 2-adrenergic receptors mediate the inhibition of ACTH stimulation of growth hormone secretion, decrease in blood pressure and inhibition of renin secretion produced by release of catecholamines in the brain, drugs with varying amounts of alpha 1- and alpha 2-adrenergic activity were injected directly into the third ventricle in pentobarbital anesthetized dogs.	Catecholamines	212-226	renin	Canis lupus familiaris	173-178
6129126-7	1982	In dogs treated with 6-hydroxydopamine, the decrease in blood pressure and ACTH and renin secretion produced by clonidine was not altered but the growth hormone response was reduced.	Oxidopamine	21-38	renin	Canis lupus familiaris	84-89
6129126-7	1982	In dogs treated with 6-hydroxydopamine, the decrease in blood pressure and ACTH and renin secretion produced by clonidine was not altered but the growth hormone response was reduced.	Clonidine	112-121	renin	Canis lupus familiaris	84-89
6185789-2	1982	An intravenous injection of 1 mg/kg captopril significantly decreased blood pressure, increased renal blood flow, and raised the renin secretion rate (RSR).	Captopril	36-45	renin	Canis lupus familiaris	129-134
6129126-6	1982	Clonidine decreased plasma renin activity, but the other agonists increased it.	Clonidine	0-9	renin	Canis lupus familiaris	27-32
7049508-0	1982	Dependence of renal vasodilator effect of captopril on prevailing plasma renin level in the dog: influence of DOCA-salt treatment.	Captopril	42-51	renin	Canis lupus familiaris	73-78
7049508-7	1982	When the data from all four groups of dogs were subjected to regression analysis, there was a significant relationship (r = 0.68) between the prevailing plasma renin activity and the increase in renal blood flow caused by captopril.	Captopril	222-231	renin	Canis lupus familiaris	160-165
7047717-1	1982	The relationship between renal prostaglandin (PG)I2 biosynthesis and renin release was examined in conscious dogs before and during renal artery constriction.	Epoprostenol	31-51	renin	Canis lupus familiaris	69-74
6751098-1	1982	Prostaglandins have been implicated as important regulators of vascular resistance during high-renin states, and they act as potent stimuli for renin release.	Prostaglandins	0-14	renin	Canis lupus familiaris	95-100
6751098-1	1982	Prostaglandins have been implicated as important regulators of vascular resistance during high-renin states, and they act as potent stimuli for renin release.	Prostaglandins	0-14	renin	Canis lupus familiaris	144-149
6751098-12	1982	In both sodium-replete and -deplete animals the increases in PRA were accompanied by proportional increases in the hepatic extraction of renin and increases in the hepatic clearance of renin.	Sodium	8-14	renin	Canis lupus familiaris	137-142
6751098-12	1982	In both sodium-replete and -deplete animals the increases in PRA were accompanied by proportional increases in the hepatic extraction of renin and increases in the hepatic clearance of renin.	Sodium	8-14	renin	Canis lupus familiaris	185-190
6751098-14	1982	These results demonstrate that PGI2 has a potent influence on both the splanchnic and renal vasculatures and the hepatic clearance of renin and thus the role of the liver in determining hyperreninemia.	Epoprostenol	31-35	renin	Canis lupus familiaris	134-139
6284909-1	1982	The hypothesis that prostaglandins participate in beta adrenoreceptor-stimulated renin release was tested by examining the effects of prostaglandin synthesis inhibition on renal nerve stimulation (0.5-5.0 Hz)-induced renin release.	Prostaglandins	20-34	renin	Canis lupus familiaris	81-86
6284909-1	1982	The hypothesis that prostaglandins participate in beta adrenoreceptor-stimulated renin release was tested by examining the effects of prostaglandin synthesis inhibition on renal nerve stimulation (0.5-5.0 Hz)-induced renin release.	Prostaglandins	20-34	renin	Canis lupus familiaris	217-222
6284909-1	1982	The hypothesis that prostaglandins participate in beta adrenoreceptor-stimulated renin release was tested by examining the effects of prostaglandin synthesis inhibition on renal nerve stimulation (0.5-5.0 Hz)-induced renin release.	Prostaglandins	20-33	renin	Canis lupus familiaris	81-86
6284909-1	1982	The hypothesis that prostaglandins participate in beta adrenoreceptor-stimulated renin release was tested by examining the effects of prostaglandin synthesis inhibition on renal nerve stimulation (0.5-5.0 Hz)-induced renin release.	Prostaglandins	20-33	renin	Canis lupus familiaris	217-222
6294394-0	1982	Stimulation of renin release from dog renal cortical slices with L-isoproterenol and dibutyryl cyclic adenosine 3",5"-monophosphate.	LEVISOPRENALINE	65-80	renin	Canis lupus familiaris	15-20
6294394-0	1982	Stimulation of renin release from dog renal cortical slices with L-isoproterenol and dibutyryl cyclic adenosine 3",5"-monophosphate.	Bucladesine	85-131	renin	Canis lupus familiaris	15-20
7051858-1	1982	Vasoactive intestinal peptide (VIP) increased plasma renin activity (PRA) in pentobarbital-anesthetized dogs.	Pentobarbital	77-90	renin	Canis lupus familiaris	53-58
7049678-0	1982	Plasma renin activity during infusion of epinephrine into the carotid and vertebral arteries of anesthetized dogs.	Epinephrine	41-52	renin	Canis lupus familiaris	7-12
7049917-0	1982	Effects of chronic sodium depletion on canine brain renin and cathepsin D activities.	Sodium	19-25	renin	Canis lupus familiaris	52-57
7049917-2	1982	The purpose of this study was twofold: to assess the effect of sodium depletion on brain renin activity; and to assess in the same regions alterations in brain renin and cathepsin D activities.	Sodium	63-69	renin	Canis lupus familiaris	89-94
7049917-3	1982	Sodium depletion caused a ninefold increase in plasma renin activity, hemoconcentration, and hyponatremia.	Sodium	0-6	renin	Canis lupus familiaris	54-59
7049917-7	1982	These observations support the view that there is an inverse relationship between plasma and brain renin activity in chronically sodium-depleted dogs.	Sodium	129-135	renin	Canis lupus familiaris	99-104
6125584-2	1982	The renal baroreceptor and macula densa mechanisms of renin release were inhibited by pretreatment with indomethacin (8 mg/kg i.v.).	Indomethacin	104-116	renin	Canis lupus familiaris	54-59
6125584-6	1982	Isoproterenol elicited a significant renin release in the presence of beta-1 adrenoceptor blockade with atenolol and in the presence of selective beta-2 adrenoceptor blockade with IPS-339.	Isoproterenol	0-13	renin	Canis lupus familiaris	37-42
6125584-6	1982	Isoproterenol elicited a significant renin release in the presence of beta-1 adrenoceptor blockade with atenolol and in the presence of selective beta-2 adrenoceptor blockade with IPS-339.	Atenolol	104-112	renin	Canis lupus familiaris	37-42
6125584-7	1982	In addition, intrarenal infusion of albuterol, a selective beta-2 adrenoceptor agonist, stimulated renin release in the absence and presence of atenolol.	Albuterol	36-45	renin	Canis lupus familiaris	99-104
6284909-2	1982	In phentolamine (5 micrograms/kg/min, intrarenal artery)-treated dogs (n = 6), renal nerve stimulation produced a frequency-related increase in renal renin secretion rate, without altering renal blood flow.	Phentolamine	3-15	renin	Canis lupus familiaris	150-155
6284912-0	1982	Effect of sodium orthovanadate on renal renin secretion in vivo.	Sodium orthovanadate	10-30	renin	Canis lupus familiaris	40-45
7047717-10	1982	In addition, there was a significant correlation between the renal secretion rates of renin and 6-keto-PGF1 alpha (r = 0.688; P less than .013; n = 12).	6-Ketoprostaglandin F1 alpha	96-113	renin	Canis lupus familiaris	86-91
6284912-1	1982	The effect of vanadate (0.5 mumol/min) on renin secretory rate (RSR) of the kidney has been studied in nembutal-anesthetized, volume-expanded dogs.	Vanadates	14-22	renin	Canis lupus familiaris	42-47
6284912-12	1982	These results clearly demonstrate that vanadate is a potent inhibitor of renin secretion and suggest that inhibition of smooth muscle Na+, K+, adenasine triphosphatase and changes in the cystosolic concentration of Na and Ca are involved in its mechanism.	Vanadates	39-47	renin	Canis lupus familiaris	73-78
7047717-11	1982	These data indicate a close association between the renal biosynthesis and PGI2 and renin release and are consistent with the concept that PGI2 participates in the release of renin.	Epoprostenol	139-143	renin	Canis lupus familiaris	84-89
7047717-11	1982	These data indicate a close association between the renal biosynthesis and PGI2 and renin release and are consistent with the concept that PGI2 participates in the release of renin.	Epoprostenol	139-143	renin	Canis lupus familiaris	175-180
6283915-1	1982	The release of renin from dog cortical kidney slice preparations incubated in a physiological salt solution can be modulated by alpha- and beta-adrenergic drugs.	Salts	94-98	renin	Canis lupus familiaris	15-20
6283915-2	1982	When given to slices maintained at 37 degrees C, the beta-agonists isoproterenol (ISP) and norepinephrine stimulated renin release from the slices.	Isoproterenol	67-80	renin	Canis lupus familiaris	117-122
6283915-2	1982	When given to slices maintained at 37 degrees C, the beta-agonists isoproterenol (ISP) and norepinephrine stimulated renin release from the slices.	Isoproterenol	82-85	renin	Canis lupus familiaris	117-122
6283915-2	1982	When given to slices maintained at 37 degrees C, the beta-agonists isoproterenol (ISP) and norepinephrine stimulated renin release from the slices.	Norepinephrine	91-105	renin	Canis lupus familiaris	117-122
6283915-4	1982	However, the alpha-agonist phenylephrine inhibited renin release from the slices incubated at 20 degrees C in a dose-dependent manner, whereas its effect on slices incubated at 37 degrees C was less pronounced.	Phenylephrine	27-40	renin	Canis lupus familiaris	51-56
7044761-2	1982	A radioactive protein believed to be renin was secreted from cortical slices into an incubation medium containing radioactive leucine.	Leucine	126-133	renin	Canis lupus familiaris	37-42
7044761-5	1982	The labeled protein, as evidenced by a peak in 3H or 14C disintegrations per min, also comigrated with renin activity in isoelectric focusing gels.	Tritium	47-49	renin	Canis lupus familiaris	103-108
7044761-5	1982	The labeled protein, as evidenced by a peak in 3H or 14C disintegrations per min, also comigrated with renin activity in isoelectric focusing gels.	Carbon-14	53-56	renin	Canis lupus familiaris	103-108
7044761-8	1982	Isoproterenol significantly increased total renin secretion from the slices, but not the secretion of newly synthesized renin.	Isoproterenol	0-13	renin	Canis lupus familiaris	44-49
6284909-0	1982	Effects of indomethacin on beta adrenoreceptor-stimulated renin release in the dog.	Indomethacin	11-23	renin	Canis lupus familiaris	58-63
7049441-3	1982	Acute infusion of nitroprusside was used to test the renin response to arterial hypotension and decreased central blood volume.	Nitroprusside	18-31	renin	Canis lupus familiaris	53-58
7047789-5	1982	Plasma renin activity rose in both hypertensive and normotensive animals during the treatment with captopril.	Captopril	99-108	renin	Canis lupus familiaris	7-12
7037854-15	1982	Finally, the results demonstrate that renal nerves are important stimuli to renin secretion in early endotoxemia via pathways that are PG-independent.	Prostaglandins	135-137	renin	Canis lupus familiaris	76-81
7067860-7	1982	Therefore, the purpose of this experiment was to investigate the roles of the renin-angiotensin system and electrolyte metabolism on plasma aldosterone concentration during acute respiratory acidosis.	Aldosterone	140-151	renin	Canis lupus familiaris	78-83
6279332-7	1982	Plasma renin activity increased 6-7 fold in the hemorrhage group as well as in the hemorrhage with phentolamine group.	Phentolamine	99-111	renin	Canis lupus familiaris	7-12
6756692-8	1982	Pepstatin severely inhibits this effect, most probably by inhibiting the new renin, possibly also by inhibiting the convertase itself.	pepstatin	0-9	renin	Canis lupus familiaris	77-82
6175823-0	1982	Prolonged infusion of norepinephrine in the conscious dog: effects on blood pressure, heart rate, renin, angiotensin II, and aldosterone.	Norepinephrine	22-36	renin	Canis lupus familiaris	98-103
7041212-7	1982	Simultaneously, renin release was most pronounced by PGA1.	prostaglandin A1	53-57	renin	Canis lupus familiaris	16-21
7040635-5	1981	Infusion noradrenaline by either route resulted in dose-related rises in plasma renin activity.	Norepinephrine	9-22	renin	Canis lupus familiaris	80-85
7028613-1	1981	Sodium depletion, a maneuver that is accompanied by a 14-fold elevation of plasma renin activity (PRA), alters the norepinephrine concentration of the canine area postrema (AP), a circumventricular organ of the 4th ventricle known to be sensitive to circulating angiotensin II.	Sodium	0-6	renin	Canis lupus familiaris	82-87
7028613-1	1981	Sodium depletion, a maneuver that is accompanied by a 14-fold elevation of plasma renin activity (PRA), alters the norepinephrine concentration of the canine area postrema (AP), a circumventricular organ of the 4th ventricle known to be sensitive to circulating angiotensin II.	Norepinephrine	115-129	renin	Canis lupus familiaris	82-87
6181344-1	1982	Patients with pulmonary dysfunction and CO2 retention have renal hemodynamic abnormalities accompanied by increased plasma renin activity.	Carbon Dioxide	40-43	renin	Canis lupus familiaris	123-128
7040235-1	1982	This study examines the hypothesis that the renal prostaglandins function as essential mediators in stimulus-secretion coupling for one or more of the basic receptor mechanisms in the control of renin release.	Prostaglandins	50-64	renin	Canis lupus familiaris	195-200
7040235-5	1982	These results fail to support the hypothesis that the renal prostaglandins function as essential mediators of the intrarenal receptor mechanisms for renin release which are activated by a decrease in renal perfusion pressure below the autoregulatory range.	Prostaglandins	60-74	renin	Canis lupus familiaris	149-154
7040240-0	1982	H-77: a potent new renin inhibitor.	H 77	0-4	renin	Canis lupus familiaris	19-24
7040240-8	1982	Thus, the in vitro effect of H-77 as an inhibitor of renin in dog, human, and rat plasma was paralleled by its action in the whole animal.	H 77	29-33	renin	Canis lupus familiaris	53-58
7039357-5	1982	Administration of propranolol (iv) or phentolamine directly into the renal artery totally blocked the increase in renin during activation of the reflex.	Propranolol	18-29	renin	Canis lupus familiaris	114-119
7039357-5	1982	Administration of propranolol (iv) or phentolamine directly into the renal artery totally blocked the increase in renin during activation of the reflex.	Phentolamine	38-50	renin	Canis lupus familiaris	114-119
7032805-2	1982	A high-molecular-weight renin (M(r) 60 000) was formed by the reaction of a low-molecular-weight renin (M(r) 40 000) with a renin-binding substance in canine renal cortical extract in the presence of the sulphydryl (SH) group oxidizing agent potassium tetrathionate; thus the reaction required SH oxidation.	Sulfhydryl Compounds	204-214	renin	Canis lupus familiaris	24-29
7032805-2	1982	A high-molecular-weight renin (M(r) 60 000) was formed by the reaction of a low-molecular-weight renin (M(r) 40 000) with a renin-binding substance in canine renal cortical extract in the presence of the sulphydryl (SH) group oxidizing agent potassium tetrathionate; thus the reaction required SH oxidation.	Sulfhydryl Compounds	204-214	renin	Canis lupus familiaris	97-102
7032805-2	1982	A high-molecular-weight renin (M(r) 60 000) was formed by the reaction of a low-molecular-weight renin (M(r) 40 000) with a renin-binding substance in canine renal cortical extract in the presence of the sulphydryl (SH) group oxidizing agent potassium tetrathionate; thus the reaction required SH oxidation.	Sulfhydryl Compounds	204-214	renin	Canis lupus familiaris	97-102
7032805-2	1982	A high-molecular-weight renin (M(r) 60 000) was formed by the reaction of a low-molecular-weight renin (M(r) 40 000) with a renin-binding substance in canine renal cortical extract in the presence of the sulphydryl (SH) group oxidizing agent potassium tetrathionate; thus the reaction required SH oxidation.	Tetrathionic Acid	242-265	renin	Canis lupus familiaris	24-29
7032805-2	1982	A high-molecular-weight renin (M(r) 60 000) was formed by the reaction of a low-molecular-weight renin (M(r) 40 000) with a renin-binding substance in canine renal cortical extract in the presence of the sulphydryl (SH) group oxidizing agent potassium tetrathionate; thus the reaction required SH oxidation.	Tetrathionic Acid	242-265	renin	Canis lupus familiaris	97-102
7032805-2	1982	A high-molecular-weight renin (M(r) 60 000) was formed by the reaction of a low-molecular-weight renin (M(r) 40 000) with a renin-binding substance in canine renal cortical extract in the presence of the sulphydryl (SH) group oxidizing agent potassium tetrathionate; thus the reaction required SH oxidation.	Tetrathionic Acid	242-265	renin	Canis lupus familiaris	97-102
7032805-4	1982	Renin extracted from isolate renin granules was adsorbed on to thiopropyl Sepharose 6B, and then liberated with dithiothreitol (50 mmol/1), indicating that it possessed on SH moiety(s).	thiopropyl-sepharose	63-86	renin	Canis lupus familiaris	0-5
7032805-4	1982	Renin extracted from isolate renin granules was adsorbed on to thiopropyl Sepharose 6B, and then liberated with dithiothreitol (50 mmol/1), indicating that it possessed on SH moiety(s).	thiopropyl-sepharose	63-86	renin	Canis lupus familiaris	29-34
7032805-4	1982	Renin extracted from isolate renin granules was adsorbed on to thiopropyl Sepharose 6B, and then liberated with dithiothreitol (50 mmol/1), indicating that it possessed on SH moiety(s).	Dithiothreitol	112-126	renin	Canis lupus familiaris	0-5
7032805-6	1982	However, the renin was capable of reaction with the renin-binding substance even after its SH moiety (or moieties) was protected with 5,5"- dithiobis-(2-nitrobenzoic acid).	Dithionitrobenzoic Acid	134-170	renin	Canis lupus familiaris	13-18
7032805-6	1982	However, the renin was capable of reaction with the renin-binding substance even after its SH moiety (or moieties) was protected with 5,5"- dithiobis-(2-nitrobenzoic acid).	Dithionitrobenzoic Acid	134-170	renin	Canis lupus familiaris	52-57
6174445-9	1982	These results indicate that the increased activity of the renin-angiotensin system that occurs during salt restriction exerts approximately equivalent vasoconstrictor influences on both preglomerular and postglomerular vascular resistance elements.	Salts	102-106	renin	Canis lupus familiaris	58-63
7028466-4	1981	In the absence of vasopressin blockade, blood pressure and heart rate did not change significantly, while plasma renin activity increased from 3.8 +/- 0.9 to 10.8 +/- 3.1 ng/ml/3h (P less than 0.005), and plasma corticosteroid concentration increased from 1.5 +/- 0.8 to 8.6 +/- 2.0 microgram/dl (P less than 0.001).	Tritium	177-179	renin	Canis lupus familiaris	113-118
7026766-5	1981	The initial decrease in conductance seen in furosemide-treated animals appears to be mediated via the renin-angiotensin system.	Furosemide	44-54	renin	Canis lupus familiaris	102-107
7026766-6	1981	In volume-repleted as well as volume-depleted animals, the plasma concentrations of renin and angiotensin II, but not antidiuretic hormone, were increased 10 min after furosemide administration.	Furosemide	168-178	renin	Canis lupus familiaris	84-108
7026766-9	1981	When fluid losses were not replaced, plasma levels of angiotensin II and renin, as well as antidiuretic hormone, were increased 40 min after furosemide administration.	Furosemide	141-151	renin	Canis lupus familiaris	54-78
7033506-13	1981	In conclusion, water intake in response to partial aortic obstruction above the level of the kidneys is caused by renin released from the kidneys.	Water	15-20	renin	Canis lupus familiaris	114-119
7049441-6	1982	After 7 days of hydralazine or prazosin administration, plasma renin activity remained elevated and blood volume increased from baseline values.	Hydralazine	16-27	renin	Canis lupus familiaris	63-68
7049441-6	1982	After 7 days of hydralazine or prazosin administration, plasma renin activity remained elevated and blood volume increased from baseline values.	Prazosin	31-39	renin	Canis lupus familiaris	63-68
7026127-0	1981	Circulating dopamine: its effect on the plasma concentrations of catecholamines, renin, angiotensin, aldosterone and vasopressin in the conscious dog.	Dopamine	12-20	renin	Canis lupus familiaris	81-86
6275455-0	1981	Effect of precursors of the 1, 2, and 3 series prostaglandins on renin release and renal blood flow in the dog.	Prostaglandins	47-61	renin	Canis lupus familiaris	65-70
6275455-3	1981	The highest dose of arachidonic acid increased renal blood flow by 54 +/- 19% and increased renin secretion rate seven-fold.	Arachidonic Acid	20-36	renin	Canis lupus familiaris	92-97
6278576-1	1981	To examine whether an alpha-adrenergic agonist, methoxamine, influences renin release solely by its haemodynamic effect, experiments were performed in anaesthetized dogs with denervated kidneys.	Methoxamine	48-59	renin	Canis lupus familiaris	72-77
6121458-0	1981	Effect of prenalterol, a beta-1-adrenoceptor agonist, on renin secretion rate in the anaesthetized dog.	Prenalterol	10-21	renin	Canis lupus familiaris	57-62
6278576-3	1981	At control blood pressure, renin release rose during infusion of methoxamine from 1.4 +/- 0.7 to 31 +/- 11 microgram/min.	Methoxamine	65-76	renin	Canis lupus familiaris	27-32
6278576-4	1981	A beta-adrenergic stimulator, isoproterenol, did not increase renin release significantly when administered alone into the renal artery, but doubled the effect of methoxamine infusion: at control blood pressure renin release rose from 0.5 +/- 0.3 to 71 +/- 17 microgram/min during combined infusion of isoproterenol and methoxamine.	Isoproterenol	30-43	renin	Canis lupus familiaris	211-216
6278576-4	1981	A beta-adrenergic stimulator, isoproterenol, did not increase renin release significantly when administered alone into the renal artery, but doubled the effect of methoxamine infusion: at control blood pressure renin release rose from 0.5 +/- 0.3 to 71 +/- 17 microgram/min during combined infusion of isoproterenol and methoxamine.	Methoxamine	163-174	renin	Canis lupus familiaris	211-216
6278576-7	1981	Isoproterenol infusion at low renal perfusion pressure doubled renin release, which was not significantly altered by additional infusion of methoxamine.	Isoproterenol	0-13	renin	Canis lupus familiaris	63-68
6278576-8	1981	The stimulatory effect of methoxamine on renin release at control blood pressure could be diminished but not prevented by infusing 2.9% NaCl intravenously in large amounts.	Methoxamine	26-37	renin	Canis lupus familiaris	41-46
6278576-10	1981	Thereby afferent arterioles are conditioned for stimulation of renin release by isoproterenol.	Isoproterenol	80-93	renin	Canis lupus familiaris	63-68
6121458-1	1981	The effects of the beta-1-adrenoceptor agonist, prenalterol, 20 microgram/kg intravenously on renin secretion rate (RSR), renal haemodynamics and sodium excretion were examined in anaesthetized dogs with innervated or denervated kidneys.	Prenalterol	48-59	renin	Canis lupus familiaris	94-99
7027580-2	1981	Numerous other studies have shown that pharmacological inhibition of prostaglandin synthesis is associated with diminished renin release.	Prostaglandins	69-82	renin	Canis lupus familiaris	123-128
6271668-1	1981	The effect of continuous intrarenal infusion of norepinephrine, isoproterenol, and methoxamine on renin release was studied in the uninephrectomized conscious dog.	Norepinephrine	48-62	renin	Canis lupus familiaris	98-103
6271668-1	1981	The effect of continuous intrarenal infusion of norepinephrine, isoproterenol, and methoxamine on renin release was studied in the uninephrectomized conscious dog.	Methoxamine	83-94	renin	Canis lupus familiaris	98-103
6271668-2	1981	Chronic intrarenal infusion of norepinephrine produced a biphasic curve of plasma renin activity (PRA) and a sustained 25 mm Hg increase in mean arterial pressure (MAP).	Norepinephrine	31-45	renin	Canis lupus familiaris	82-87
6271668-11	1981	This increase in PRA was blocked by phentolamine, suggesting a vascular alpha-adrenergic receptor-mediated release of renin.	Phentolamine	36-48	renin	Canis lupus familiaris	118-123
7027580-16	1981	This renin response to HBO seems best related to the previously documented inhibition of renal prostaglandin synthesis.	Prostaglandins	95-108	renin	Canis lupus familiaris	5-10
7027580-17	1981	These experiments provide nonpharmacological evidence that there may be a functional relationship between the renin-angiotensin system and renal prostaglandin release in awake animals.	Prostaglandins	145-158	renin	Canis lupus familiaris	110-115
7018734-0	1981	Effects of indomethacin, renal denervation, and propranolol on plasma renin activity in conscious dogs with chronic thoracic caval constriction.	Propranolol	48-59	renin	Canis lupus familiaris	70-75
7270714-1	1981	Reduction of sodium intake affects both the renin-angiotensin and sympathetic nervous systems, but the effects on the latter are less well understood.	Sodium	13-19	renin	Canis lupus familiaris	44-49
7018734-2	1981	Indomethacin reduced plasma renin activity (PRA) in intact animals with thoracic caval constriction by 43% but failed to change PRA after surgical renal denervation and during chronic propranolol administration; adrenergic blockade reduced the initial control level of PRA before indomethacin from 15 to 4 ng angiotensin I/ml per hr.	Indomethacin	0-12	renin	Canis lupus familiaris	28-33
7018734-4	1981	These observations indicate that prostaglandins are involved in the control of renin release, but they appear to have a more important role in the control of renal arterial resistance.	Prostaglandins	33-47	renin	Canis lupus familiaris	79-84
6269043-0	1981	The role of prostaglandins in the alpha- and beta-adrenoceptor mediated renin release response to graded renal nerve stimulation.	Prostaglandins	12-26	renin	Canis lupus familiaris	72-77
6270304-0	1981	Alpha adrenergic-mediated renin release is prostaglandin-dependent.	Prostaglandins	43-56	renin	Canis lupus familiaris	26-31
6269043-1	1981	The role of prostaglandins in the renin release response to renal nerve stimulation (RNS) at different intensities was examined in the anaesthetized dog.	Prostaglandins	12-26	renin	Canis lupus familiaris	34-39
6270304-2	1981	Increasing doses of intrarenal phenylephrine resulted in a dose-dependent decrease in renal blood flow, a dose-dependent decrease in urinary excretion of sodium and a stimulation of renal renin release which was not dose-dependent.	Phenylephrine	31-44	renin	Canis lupus familiaris	188-193
6270304-3	1981	The effect of intrarenal phenylephrine on renin release was totally abolished by pretreating the dogs with indomethacin, even though neither the vasoconstriction nor the decrement in urinary sodium excretion was altered by the drug.	Phenylephrine	25-38	renin	Canis lupus familiaris	42-47
6269043-1	1981	The role of prostaglandins in the renin release response to renal nerve stimulation (RNS) at different intensities was examined in the anaesthetized dog.	Reactive Nitrogen Species	85-88	renin	Canis lupus familiaris	34-39
6270304-3	1981	The effect of intrarenal phenylephrine on renin release was totally abolished by pretreating the dogs with indomethacin, even though neither the vasoconstriction nor the decrement in urinary sodium excretion was altered by the drug.	Indomethacin	107-119	renin	Canis lupus familiaris	42-47
6269043-4	1981	), prostaglandin synthesis inhibitors, did not affect the renin release response to low level RNS but decreased the renin release response to high level RNS by 31 +/- 8% (P less than 0.01).	Reactive Nitrogen Species	153-156	renin	Canis lupus familiaris	116-121
6270304-5	1981	These data are consistent with the hypothesis that exogenous renal alpha adrenergic stimulation in the dog contributes to renin release through the prostaglandin system and that the stimulation of the macula densa mechanism is responsible for the major effect of phenylephrine on renin release.	Phenylephrine	263-276	renin	Canis lupus familiaris	280-285
6269043-6	1981	beta-1-adrenoceptor antagonist, to indomethacin or diclofenac sodium resulted in a greater reduction (68 +/- 6% P less than 0.01) of the renin release response to high level RNS compared to that produced by either drug alone.	Indomethacin	35-47	renin	Canis lupus familiaris	137-142
6269043-6	1981	beta-1-adrenoceptor antagonist, to indomethacin or diclofenac sodium resulted in a greater reduction (68 +/- 6% P less than 0.01) of the renin release response to high level RNS compared to that produced by either drug alone.	Diclofenac	51-68	renin	Canis lupus familiaris	137-142
6269043-6	1981	beta-1-adrenoceptor antagonist, to indomethacin or diclofenac sodium resulted in a greater reduction (68 +/- 6% P less than 0.01) of the renin release response to high level RNS compared to that produced by either drug alone.	Reactive Nitrogen Species	174-177	renin	Canis lupus familiaris	137-142
6264792-2	1981	The effect of alpha-adrenoceptor blockade by phenoxybenzamine (POB) or prazosin on renin secretion rate (RSR) was studied in pentobarbital-anesthetized dogs in which renal perfusion pressure was held constant with an adjustable aortic clamp.	Prazosin	71-79	renin	Canis lupus familiaris	83-88
6264792-8	1981	These data indicate that when beta-adrenoceptors are blocked by propranolol, tonic neural stimulation of renin secretion is mediated by renal alpha-adrenoceptors.	Propranolol	64-75	renin	Canis lupus familiaris	105-110
7018258-0	1981	Adrenergically induced renin release in conscious indomethacin-treated dogs and rats.	Indomethacin	50-62	renin	Canis lupus familiaris	23-28
7013503-3	1981	Indomethacin produced striking reductions in plasma renin activity from the high level observed during the acute phase of both 1-KHT and 2-KHT.	Indomethacin	0-12	renin	Canis lupus familiaris	52-57
7018258-8	1981	Additionally, in dogs the renin responses to these adrenergic agents were even greater after indomethacin administration than before the drug.	Indomethacin	93-105	renin	Canis lupus familiaris	26-31
7018259-7	1981	The results indicate that renal PG release during group perfusion is mainly due to the activation of the renin-angiotensin system and that the hypotension due to pump perfusion is PG mediated.	Prostaglandins	32-34	renin	Canis lupus familiaris	105-110
7018807-8	1981	Plasma renin activity and aldosterone increased during development of hypertension and remained elevated during the period of sodium restriction.	Sodium	126-132	renin	Canis lupus familiaris	7-12
6269043-7	1981	Metoprolol, alone, reduced the renin release response to high level RNS by 37 +/- 14% (P less than 0.05).	Metoprolol	0-10	renin	Canis lupus familiaris	31-36
6269043-7	1981	Metoprolol, alone, reduced the renin release response to high level RNS by 37 +/- 14% (P less than 0.05).	Reactive Nitrogen Species	68-71	renin	Canis lupus familiaris	31-36
6269043-11	1981	Addition of metoprolol to phenoxybenzamine practically abolished the renal vasoconstrictor response and the renin release response to high level RNS; 94 +/- 4% (P less than 0.01).	Metoprolol	12-22	renin	Canis lupus familiaris	108-113
6269043-11	1981	Addition of metoprolol to phenoxybenzamine practically abolished the renal vasoconstrictor response and the renin release response to high level RNS; 94 +/- 4% (P less than 0.01).	Phenoxybenzamine	26-42	renin	Canis lupus familiaris	108-113
6269043-11	1981	Addition of metoprolol to phenoxybenzamine practically abolished the renal vasoconstrictor response and the renin release response to high level RNS; 94 +/- 4% (P less than 0.01).	Reactive Nitrogen Species	145-148	renin	Canis lupus familiaris	108-113
6269043-13	1981	These findings suggest that low level RNS results in renin release which is not dependent on prostaglandins.	Reactive Nitrogen Species	38-41	renin	Canis lupus familiaris	53-58
6269043-14	1981	High level RNS results in renin release which is partly mediated by beta-1-adrenoceptors and partly related to alpha-adrenoceptors mediated renal vasoconstriction.	Reactive Nitrogen Species	11-14	renin	Canis lupus familiaris	26-31
7265982-10	1981	The decrease of renin synthesis by indomethacin must be provoked by the inhibition of an other substance than the PGE and PGF and 2) the role of PGE in renal haemodynamic and exocrine renal function seems to be important.	Indomethacin	35-47	renin	Canis lupus familiaris	16-21
7265982-10	1981	The decrease of renin synthesis by indomethacin must be provoked by the inhibition of an other substance than the PGE and PGF and 2) the role of PGE in renal haemodynamic and exocrine renal function seems to be important.	Prostaglandins E	114-117	renin	Canis lupus familiaris	16-21
7265982-10	1981	The decrease of renin synthesis by indomethacin must be provoked by the inhibition of an other substance than the PGE and PGF and 2) the role of PGE in renal haemodynamic and exocrine renal function seems to be important.	Prostaglandins F	122-125	renin	Canis lupus familiaris	16-21
7013503-3	1981	Indomethacin produced striking reductions in plasma renin activity from the high level observed during the acute phase of both 1-KHT and 2-KHT.	1-kht	127-132	renin	Canis lupus familiaris	52-57
7013503-3	1981	Indomethacin produced striking reductions in plasma renin activity from the high level observed during the acute phase of both 1-KHT and 2-KHT.	2-kht	137-142	renin	Canis lupus familiaris	52-57
7013503-8	1981	The data indicate that prostaglandins are involved in renovascular hypertension in the dog only under conditions where plasma renin activity is elevated.	Prostaglandins	23-37	renin	Canis lupus familiaris	126-131
7013503-9	1981	It is suggested that the release of renin after renal artery constriction is mediated by the vascular receptor that is at least partially independent of renal prostaglandin synthesis.	Prostaglandins	159-172	renin	Canis lupus familiaris	36-41
7011963-3	1981	Three weeks of sodium depletion supplemented with diuretics caused a 24-fold increase in plasma renin activity, hemoconcentration, and elevated serum protein concentration.	Sodium	15-21	renin	Canis lupus familiaris	96-101
7011963-8	1981	The CSF norepinephrine was related inversely to the CSF sodium concentration and directly to plasma renin activity.	Norepinephrine	8-22	renin	Canis lupus familiaris	100-105
6257882-12	1981	The results indicate that captopril is effective in reducing blood pressure for an extended period of time in a hypertensive model in which the level of activity of the renin angiotensin system is not elevated.	Captopril	26-35	renin	Canis lupus familiaris	169-174
6798201-0	1981	Control of canine renin release: macula densa requires prostaglandin synthesis.	Prostaglandins	55-68	renin	Canis lupus familiaris	18-23
7011235-0	1981	[Effect of sub-pressor doses of dopamine on renin secretion in the anesthetized dog].	Dopamine	32-40	renin	Canis lupus familiaris	44-49
6120802-0	1981	Inhibition of renin secretion by clonidine after alpha-adrenoceptor blockade in anesthetized dogs.	Clonidine	33-42	renin	Canis lupus familiaris	14-19
6120802-1	1981	Dogs anaesthetised with pentobarbital were used to study the effects of the alpha-adrenoceptor antagonists phentolamine and piperoxan on the clonidine-induced suppression of plasma renin activity (PRA).	Piperoxan	124-133	renin	Canis lupus familiaris	181-186
6120802-1	1981	Dogs anaesthetised with pentobarbital were used to study the effects of the alpha-adrenoceptor antagonists phentolamine and piperoxan on the clonidine-induced suppression of plasma renin activity (PRA).	Clonidine	141-150	renin	Canis lupus familiaris	181-186
6120802-10	1981	These results demonstrate that the renin-lowering action of clonidine in the dog is not inhibited by two classical alpha-adrenoceptor antagonists.	Clonidine	60-69	renin	Canis lupus familiaris	35-40
7005428-1	1981	Several studies indicate that prostaglandin (PG) I2 is involved in the control of renin release.	Epoprostenol	30-51	renin	Canis lupus familiaris	82-87
7005428-2	1981	This investigation was performed to determine if the active possible metabolite of PGI2, 6-keto-PGE1, is also a renin secretagogue.	Epoprostenol	83-87	renin	Canis lupus familiaris	112-117
7005428-2	1981	This investigation was performed to determine if the active possible metabolite of PGI2, 6-keto-PGE1, is also a renin secretagogue.	6-ketoprostaglandin E1	89-100	renin	Canis lupus familiaris	112-117
7005428-10	1981	We conclude that, in the canine kidney, 6-keto-PGE1 is more potent than PGI2 in stimulating the juxtaglomerular cells to secrete renin.	6-ketoprostaglandin E1	40-51	renin	Canis lupus familiaris	129-134
7005428-10	1981	We conclude that, in the canine kidney, 6-keto-PGE1 is more potent than PGI2 in stimulating the juxtaglomerular cells to secrete renin.	Epoprostenol	72-76	renin	Canis lupus familiaris	129-134
6798201-6	1981	Indomethacin (8 mg/kg) or meclofenamic acid (10 mg/kg) inhibited the rise plasma renin activity produced by the decrease in renal perfusion pressure in this model, although a comparable decrease in urinary sodium excretion was achieved.	Indomethacin	0-12	renin	Canis lupus familiaris	81-86
6798201-6	1981	Indomethacin (8 mg/kg) or meclofenamic acid (10 mg/kg) inhibited the rise plasma renin activity produced by the decrease in renal perfusion pressure in this model, although a comparable decrease in urinary sodium excretion was achieved.	Meclofenamic Acid	26-43	renin	Canis lupus familiaris	81-86
6798201-8	1981	We conclude that the macula densa mechanism of renin release is blocked by inhibition of prostaglandin synthesis.	Prostaglandins	89-102	renin	Canis lupus familiaris	47-52
7022537-2	1981	Systemic blood pressure was decreased and arterial plasma renin concentration increased in the sodium-loaded dogs by infusion of PGI2 (1200 ng/min).	Sodium	95-101	renin	Canis lupus familiaris	58-63
7029689-3	1981	Renin activity was increased to varying levels by raising ureteric pressure and by the administration of different doses of furosemide.	Furosemide	124-134	renin	Canis lupus familiaris	0-5
7022537-2	1981	Systemic blood pressure was decreased and arterial plasma renin concentration increased in the sodium-loaded dogs by infusion of PGI2 (1200 ng/min).	Epoprostenol	129-133	renin	Canis lupus familiaris	58-63
7022537-4	1981	In the sodium-depleted dogs systemic blood pressure was significantly decreased and arterial plasma renin concentration increased by infusions of PGI2 (300 and 1200 ng/min) and PGE2 (300 ng/min).	Sodium	7-13	renin	Canis lupus familiaris	100-105
7022537-4	1981	In the sodium-depleted dogs systemic blood pressure was significantly decreased and arterial plasma renin concentration increased by infusions of PGI2 (300 and 1200 ng/min) and PGE2 (300 ng/min).	Epoprostenol	146-150	renin	Canis lupus familiaris	100-105
7022537-4	1981	In the sodium-depleted dogs systemic blood pressure was significantly decreased and arterial plasma renin concentration increased by infusions of PGI2 (300 and 1200 ng/min) and PGE2 (300 ng/min).	Dinoprostone	177-181	renin	Canis lupus familiaris	100-105
7004725-2	1980	The low-molecular-weight (40 000) form of renin was converted into the high-molecular-weight (60 000) form of renin with sulphydryl oxidation, and the high-molecular-weight form of renin was re-converted into the low-molecular-weight form with a reduction of disulphide bonds in the renal cortical homogenate of the dog.	Sulfhydryl Compounds	121-131	renin	Canis lupus familiaris	42-47
7004725-2	1980	The low-molecular-weight (40 000) form of renin was converted into the high-molecular-weight (60 000) form of renin with sulphydryl oxidation, and the high-molecular-weight form of renin was re-converted into the low-molecular-weight form with a reduction of disulphide bonds in the renal cortical homogenate of the dog.	Sulfhydryl Compounds	121-131	renin	Canis lupus familiaris	110-115
7004725-2	1980	The low-molecular-weight (40 000) form of renin was converted into the high-molecular-weight (60 000) form of renin with sulphydryl oxidation, and the high-molecular-weight form of renin was re-converted into the low-molecular-weight form with a reduction of disulphide bonds in the renal cortical homogenate of the dog.	Sulfhydryl Compounds	121-131	renin	Canis lupus familiaris	110-115
7004725-2	1980	The low-molecular-weight (40 000) form of renin was converted into the high-molecular-weight (60 000) form of renin with sulphydryl oxidation, and the high-molecular-weight form of renin was re-converted into the low-molecular-weight form with a reduction of disulphide bonds in the renal cortical homogenate of the dog.	disulphide	259-269	renin	Canis lupus familiaris	42-47
7004725-2	1980	The low-molecular-weight (40 000) form of renin was converted into the high-molecular-weight (60 000) form of renin with sulphydryl oxidation, and the high-molecular-weight form of renin was re-converted into the low-molecular-weight form with a reduction of disulphide bonds in the renal cortical homogenate of the dog.	disulphide	259-269	renin	Canis lupus familiaris	110-115
7004725-2	1980	The low-molecular-weight (40 000) form of renin was converted into the high-molecular-weight (60 000) form of renin with sulphydryl oxidation, and the high-molecular-weight form of renin was re-converted into the low-molecular-weight form with a reduction of disulphide bonds in the renal cortical homogenate of the dog.	disulphide	259-269	renin	Canis lupus familiaris	110-115
7004725-7	1980	The renin binding substance of the dog was unstable to heat and low pH, but vitally resistant to Triton X-100 and chloroform.	Octoxynol	97-109	renin	Canis lupus familiaris	4-9
7004725-7	1980	The renin binding substance of the dog was unstable to heat and low pH, but vitally resistant to Triton X-100 and chloroform.	Chloroform	114-124	renin	Canis lupus familiaris	4-9
7004725-10	1980	The renin binding substance was eluted in the molecular-weight region between 156 000 and 60 000 on Sephadex G-200, and such apparent molecular weight was not altered by urea at 4 mol/l; thus molecular weight greater than the theoretically expected value of 20 000 was indicated.	sephadex	100-114	renin	Canis lupus familiaris	4-9
7001085-9	1980	Given intrarenally in a dose of 1 microgram/min, PGI2 and PGE2 increased renin release.	Epoprostenol	49-53	renin	Canis lupus familiaris	73-78
7004737-11	1980	Simultaneous intraventricular administrations of captopril with renin inhibited the central renin effects.	Captopril	49-58	renin	Canis lupus familiaris	92-97
7003179-0	1980	The effect of angiotensin II antagonist, Sar1-Ile8-angiotensin II, on furosemide-induced increase in plasma noradrenaline, renin activity and aldosterone in unanesthetized dogs.	Furosemide	70-80	renin	Canis lupus familiaris	123-128
7003179-2	1980	Furthermore, the role of the renin-angiotensin system in the increased sympathetic nerve activity induced by furosemide was assessed by using Sar1-Ile8-angiotensin II, an angiotensin II antagonist.	Furosemide	109-119	renin	Canis lupus familiaris	29-34
7003179-6	1980	There results suggest that an administration of furosemide induced the increase in PNA and the increase in PNA by furosemide might by mediated by the renin-angiotensin system.	Furosemide	48-58	renin	Canis lupus familiaris	150-155
7003179-6	1980	There results suggest that an administration of furosemide induced the increase in PNA and the increase in PNA by furosemide might by mediated by the renin-angiotensin system.	Furosemide	114-124	renin	Canis lupus familiaris	150-155
7001085-9	1980	Given intrarenally in a dose of 1 microgram/min, PGI2 and PGE2 increased renin release.	Dinoprostone	58-62	renin	Canis lupus familiaris	73-78
6999033-4	1980	The arterial plasma renin activity and concentration of norepinephrine were higher in the sodium-depleted animals than in the controls; the arterial concentration of PGE2 was equal in both groups.	Sodium	90-96	renin	Canis lupus familiaris	20-25
7001085-12	1980	Present data indicate that PGI2 and PGE2 stimulate renin secretion through a direct action on the juxtaglomerular cells.	Epoprostenol	27-31	renin	Canis lupus familiaris	51-56
7001085-12	1980	Present data indicate that PGI2 and PGE2 stimulate renin secretion through a direct action on the juxtaglomerular cells.	Dinoprostone	36-40	renin	Canis lupus familiaris	51-56
6108746-1	1980	Bucindolol (MJ 13105), administered to conscious, normotensive dogs (a) attenuated the positive chronotropic and diastolic depressor response elicited by isoproterenol, (b) increased heart rate and (c) elevated plasma renin activity (PRA).	bucindolol	0-10	renin	Canis lupus familiaris	218-223
6999033-5	1980	The renal venous plasma renin activity was higher in the sodium-depleted dogs.	Sodium	57-63	renin	Canis lupus familiaris	24-29
6999033-9	1980	The results indicate that moderate chronic sodium depletion, in addition to enhancing the activity of the renin-angiotensin system, also increases the activity of the renal adrenergic nervous system and increases renal PGE2 synthesis.	Sodium	43-49	renin	Canis lupus familiaris	106-111
6107894-5	1980	The renin release response was almost abolished by 0.5 mg/kg of metoprolol or dl-propranolol but unaffected by 0.5 mg/kg of d-propranolol.	Metoprolol	64-74	renin	Canis lupus familiaris	4-9
6107894-5	1980	The renin release response was almost abolished by 0.5 mg/kg of metoprolol or dl-propranolol but unaffected by 0.5 mg/kg of d-propranolol.	Propranolol	78-92	renin	Canis lupus familiaris	4-9
6107894-6	1980	The increase in renin release to high level RNS was equally reduced by 33% by 0.5 mg/kg and 2.0 mg/kg of metoprolol.	Reactive Nitrogen Species	44-47	renin	Canis lupus familiaris	16-21
6107894-6	1980	The increase in renin release to high level RNS was equally reduced by 33% by 0.5 mg/kg and 2.0 mg/kg of metoprolol.	Metoprolol	105-115	renin	Canis lupus familiaris	16-21
6107894-7	1980	dl-propranolol, 0.5 mg/kg, reduced the renin release response to about the same extent, 44%, while 2.0 mg/kg reduced it somewhat more, 59%.	Propranolol	0-14	renin	Canis lupus familiaris	39-44
6107894-8	1980	This was probably due to its membrane stabilizing properties as d-propranolol, 2.0 mg/kg and lidocaine 2.0 mg/kg + 0.1 mg x kg-1 x min-1, also reduced the renin release response.	Propranolol	64-77	renin	Canis lupus familiaris	155-160
6107894-8	1980	This was probably due to its membrane stabilizing properties as d-propranolol, 2.0 mg/kg and lidocaine 2.0 mg/kg + 0.1 mg x kg-1 x min-1, also reduced the renin release response.	Lidocaine	93-102	renin	Canis lupus familiaris	155-160
6107894-9	1980	These data suggest that the renin release response to low level RNS is almost completely mediated by beta-adrenoceptors which are of the beta-1 subtype.	Reactive Nitrogen Species	64-67	renin	Canis lupus familiaris	28-33
6107894-10	1980	High level RNS results in a renin release, which is only partly mediated by beta-1-adrenoceptors.	Reactive Nitrogen Species	11-14	renin	Canis lupus familiaris	28-33
6994510-0	1980	Inhibition of renin secretion by HCl is related to chloride in both dog and rat.	Hydrochloric Acid	33-36	renin	Canis lupus familiaris	14-19
6248808-0	1980	Sites at which clonidine acts to affect blood pressure and the secretion of renin, growth hormone and ACTH.	Clonidine	15-24	renin	Canis lupus familiaris	76-81
6248808-1	1980	To further define the sites in the brain at which clonidine acts to lower blood pressure, inhibit renin secretion, inhibit ACTH secretion, and stimulate growth hormone secretion, small doses of this drug were infused into the vertebral arteries, into the carotid arteries and intravenously in pentobarbital-anesthetized dogs.	Clonidine	50-59	renin	Canis lupus familiaris	98-103
6248808-6	1980	Intracarotid and intravertebral clonidine decreased plasma renin activity whereas in this dose intravenous clonidine did not.	Clonidine	32-41	renin	Canis lupus familiaris	59-64
6248808-10	1980	The data confirm the observation that clonidine acts on the brain to inhibit renin secretion, and establish that the renin-inhibiting site is different from the blood pressure-lowering site.	Clonidine	38-47	renin	Canis lupus familiaris	77-82
6991156-0	1980	Effects of indomethacin and meclofenamate on renin release and renal hemodynamic function during chronic sodium depletion in conscious dogs.	Meclofenamic Acid	28-41	renin	Canis lupus familiaris	45-50
6247919-2	1980	Progressive sodium depletion was associated with progressive increased in basal (pre-ACTH) plasma levels of renin, angiotensin II, aldosterone, 18-hydroxycorticosterone (18-OH-B), and 18-hydroxy-11-deoxycorticosterone (18-OH-DOC).	Sodium	12-18	renin	Canis lupus familiaris	108-113
7005423-1	1980	The roles of renin-angiotensin system and renal prostaglandins (PGs) in mediating the renal vasodilator response of captopril were studied in anesthetized nonhypotensive hemorrhaged dogs.	Captopril	116-125	renin	Canis lupus familiaris	13-18
7005423-10	1980	These results suggest that under the conditions of these experiments the renal vasodilator effect of captopril is due to the blockade of the renin-angiotensin system and is not associated with either renal PGE release or PG-induced vasodilatation.	Captopril	101-110	renin	Canis lupus familiaris	141-146
6991156-2	1980	Indomethacin (10 mg/kg) reduced plasma renin activity (PRA) by 59% from a high sodium-depleted value, but PRA was still 3 times the normal sodium-repleted level.	Indomethacin	0-12	renin	Canis lupus familiaris	39-44
6991156-6	1980	This high level of PRA after blockade of the adrenergic nervous system and injection of indomethacin suggests that important mechanisms other than norepinephrine and renal prostaglandins control renin release; it is proposed that both the renal vascular receptor and the macula densa are involved.	Indomethacin	88-100	renin	Canis lupus familiaris	195-200
6993655-3	1980	Plasma renin activity (PRA) during sodium depletion (12.35 +/- 3.93 ng ml-1 hr-1) was higher than during sodium repletion (1.46 +/- 0.47 ng ml-1 hr-1; P less than .05).	Sodium	35-41	renin	Canis lupus familiaris	7-12
6155226-0	1980	The acute effect of lithium on renal renin and prostaglandin E synthesis in the dog.	Lithium	20-27	renin	Canis lupus familiaris	37-42
6994510-0	1980	Inhibition of renin secretion by HCl is related to chloride in both dog and rat.	Chlorides	51-59	renin	Canis lupus familiaris	14-19
7000412-8	1980	Dithiothreitol neither inhibited the conversion into the higher-molecular-weight form of renin during cold storage nor led to a reduction in the molecular weight of renin, although the oxidation of thiol groups has been proposed as the mechanism for the molecular-weight conversion of renin.	Dithiothreitol	0-14	renin	Canis lupus familiaris	89-94
7000412-8	1980	Dithiothreitol neither inhibited the conversion into the higher-molecular-weight form of renin during cold storage nor led to a reduction in the molecular weight of renin, although the oxidation of thiol groups has been proposed as the mechanism for the molecular-weight conversion of renin.	Dithiothreitol	0-14	renin	Canis lupus familiaris	165-170
7000412-8	1980	Dithiothreitol neither inhibited the conversion into the higher-molecular-weight form of renin during cold storage nor led to a reduction in the molecular weight of renin, although the oxidation of thiol groups has been proposed as the mechanism for the molecular-weight conversion of renin.	Dithiothreitol	0-14	renin	Canis lupus familiaris	165-170
6990795-0	1980	Role of the renin-angiotensin system in potassium control.	Potassium	40-49	renin	Canis lupus familiaris	12-17
6103674-0	1980	Analysis of beta-adrenoceptors mediating renin release produced by isoproterenol in conscious dogs.	Isoproterenol	67-80	renin	Canis lupus familiaris	41-46
6103674-1	1980	Types of beta-adrenoceptors mediating renin release induced by isoproterenol were investigated in conscious dogs.	Isoproterenol	63-76	renin	Canis lupus familiaris	38-43
6990795-9	1980	The results demonstrate the importance of the renin-angiotensin system as a link between the nephron and the zona glomerulosa that is essential in controlling plasma potassium concentration and excretion during changes in sodium balance.	Potassium	166-175	renin	Canis lupus familiaris	46-51
6103674-2	1980	The nonselective beta-adrenoceptor blocking drugs propranolol, D-32, and pindolol significantly inhibited increases in heart rate and plasma renin activity and a fall of blood pressure produced by intravenous infusion of isoproterenol (10 microgram .	Propranolol	50-61	renin	Canis lupus familiaris	141-146
6990795-9	1980	The results demonstrate the importance of the renin-angiotensin system as a link between the nephron and the zona glomerulosa that is essential in controlling plasma potassium concentration and excretion during changes in sodium balance.	Sodium	222-228	renin	Canis lupus familiaris	46-51
6994184-0	1980	Relationship between plasma renin activity and hypotensive effect of captopril in dogs.	Captopril	69-78	renin	Canis lupus familiaris	28-33
6103674-2	1980	The nonselective beta-adrenoceptor blocking drugs propranolol, D-32, and pindolol significantly inhibited increases in heart rate and plasma renin activity and a fall of blood pressure produced by intravenous infusion of isoproterenol (10 microgram .	xibenolol	63-67	renin	Canis lupus familiaris	141-146
6103674-2	1980	The nonselective beta-adrenoceptor blocking drugs propranolol, D-32, and pindolol significantly inhibited increases in heart rate and plasma renin activity and a fall of blood pressure produced by intravenous infusion of isoproterenol (10 microgram .	Pindolol	73-81	renin	Canis lupus familiaris	141-146
6103674-2	1980	The nonselective beta-adrenoceptor blocking drugs propranolol, D-32, and pindolol significantly inhibited increases in heart rate and plasma renin activity and a fall of blood pressure produced by intravenous infusion of isoproterenol (10 microgram .	Isoproterenol	221-234	renin	Canis lupus familiaris	141-146
6103674-6	1980	The selective beta 1-adrenoceptor blocking drug atenolol, at the oral dose of 6 mg/kg, which selectively suppressed isoproterenol-induced tachycardia, significantly inhibited the renin release caused by isoproterenol.	Atenolol	48-56	renin	Canis lupus familiaris	179-184
6103674-6	1980	The selective beta 1-adrenoceptor blocking drug atenolol, at the oral dose of 6 mg/kg, which selectively suppressed isoproterenol-induced tachycardia, significantly inhibited the renin release caused by isoproterenol.	Isoproterenol	203-216	renin	Canis lupus familiaris	179-184
6103674-7	1980	By contrast, the renin release induced by isoproterenol was not modified by the selective beta 2-adrenoceptor blocking drug IPS-339 at an oral dose of 3 mg/kg, which fully and selectively antagonized the fall of blood pressure in response to isoproterenol.	Isoproterenol	42-55	renin	Canis lupus familiaris	17-22
6103674-8	1980	There was good correlation between suppression of isoproterenol-induced renin release and that of isoproterenol-induced tachycardia after various beta-adrenoceptor blocking drugs.	Isoproterenol	50-63	renin	Canis lupus familiaris	72-77
6994184-4	1980	Further, the hypotensive action of captopril was not related to the level of plasma renin activity, since the morphine-chloralose dogs had a significantly higher plasma renin activity.	Captopril	35-44	renin	Canis lupus familiaris	169-174
6990367-0	1980	The renin angiotensin system in newborn dogs: developmental patterns and response to acute saline loading.	Sodium Chloride	91-97	renin	Canis lupus familiaris	4-9
7005498-16	1980	Both PGE2 and I2 may participate in the control of renin secretion.	Dinoprostone	5-9	renin	Canis lupus familiaris	51-56
6986653-4	1980	These observations establish the role of the renin-angiotensin system in the maintenance of blood pressure in the sodium-depleted state as well as in the initiation of renovascular hypertension.	Sodium	114-120	renin	Canis lupus familiaris	45-50
6991409-0	1980	Suppression of stimulated plasma renin by clonidine in the dog.	Clonidine	42-51	renin	Canis lupus familiaris	33-38
6994708-0	1980	The effect of single and repeated oral doses of isosorbide dinitrate on plasma renin activity and plasma catecholamine levels in conscious dogs.	Isosorbide Dinitrate	48-68	renin	Canis lupus familiaris	79-84
6991409-1	1980	The mechanism by which clonidine suppresses plasma renin activity (PRA) was investigated in dogs anesthetized with pentobarbital.	Clonidine	23-32	renin	Canis lupus familiaris	51-56
6991409-7	1980	These results indicate that clonidine reduces stimulated renin by a central mechanism that is dependent upon the integrity of the sympathetic innervation of the kidney.	Clonidine	28-37	renin	Canis lupus familiaris	57-62
6991409-8	1980	Other stimuli for renin release may override the inhibitory effect of central clonidine.	Clonidine	78-87	renin	Canis lupus familiaris	18-23
6989185-3	1980	PGSI abolish PG modulation of the renin-angiotensin system, and this effect appears to account for the increased renal vascular tone induced in furosemide- and low-salt-treated dogs.	pgsi	0-4	renin	Canis lupus familiaris	34-39
6989185-3	1980	PGSI abolish PG modulation of the renin-angiotensin system, and this effect appears to account for the increased renal vascular tone induced in furosemide- and low-salt-treated dogs.	pg	0-2	renin	Canis lupus familiaris	34-39
7008886-2	1980	The effect of a hypotensive dose of intravenous prazosin (0.2 mg/kg) on heart rate and plasma renin activity was evaluated in anaesthetized mongrel dogs pretreated with indomethacin.	Prazosin	48-56	renin	Canis lupus familiaris	94-99
7008886-4	1980	The effect of prazosin on the renin release elicited by the beta-adrenoceptor agonist isoprenaline and by prostaglandin I2 was also evaluated.	Isoproterenol	86-98	renin	Canis lupus familiaris	30-35
7008886-6	1980	Prazosin administration was associated with a significant increase in heart rate and increase in plasma renin activity.	Prazosin	0-8	renin	Canis lupus familiaris	104-109
6991148-3	1980	Plasma renin activity and outer cortical blood flow were significantly greater in the group of dogs receiving dopamine.	Dopamine	110-118	renin	Canis lupus familiaris	7-12
7008886-10	1980	We conclude that prazosin is not a unique peripheral vasodilator since hypotensive doses are associated with an increase in heart rate and plasma renin activity.	Prazosin	17-25	renin	Canis lupus familiaris	146-151
225056-8	1979	These data demonstrate an important role for aldosterone and the renin-angiotensin system in the retention of sodium and in ascites formation in dogs with thoracic caval constriction.	Sodium	110-116	renin	Canis lupus familiaris	65-70
6991284-0	1980	[Mechanism of the stimulating effect of furosemide, ethacrynic acid and novurit on renin secretion by the kidneys].	Furosemide	40-50	renin	Canis lupus familiaris	83-88
6989757-10	1980	Administration of furosemide was utilized to increase plasma renin activity (PRA) in another series of experiments.	Furosemide	18-28	renin	Canis lupus familiaris	61-66
6986577-1	1980	To determine if serotonin plays a role in the regulation of renin secretion, pentobarbital-anesthetized dogs were injected intravenously with drugs which modify serotonin metabolism.	Serotonin	16-25	renin	Canis lupus familiaris	60-65
6986577-3	1980	5-Hydroxytryptophan (5-HTP) caused a significant increase (p less than 0.05) in arterial plasma renin activity (pra) that was abolished when peripheral and central aromatic amino acid decarboxylase activities were inhibited by administration of benserazide, but not reduced when only the peripheral decarboxylase activities were inhibited by administration of carbidopa.	5-Hydroxytryptophan	0-19	renin	Canis lupus familiaris	96-101
6986577-3	1980	5-Hydroxytryptophan (5-HTP) caused a significant increase (p less than 0.05) in arterial plasma renin activity (pra) that was abolished when peripheral and central aromatic amino acid decarboxylase activities were inhibited by administration of benserazide, but not reduced when only the peripheral decarboxylase activities were inhibited by administration of carbidopa.	5-Hydroxytryptophan	21-26	renin	Canis lupus familiaris	96-101
6986577-3	1980	5-Hydroxytryptophan (5-HTP) caused a significant increase (p less than 0.05) in arterial plasma renin activity (pra) that was abolished when peripheral and central aromatic amino acid decarboxylase activities were inhibited by administration of benserazide, but not reduced when only the peripheral decarboxylase activities were inhibited by administration of carbidopa.	Benserazide	245-256	renin	Canis lupus familiaris	96-101
6986577-3	1980	5-Hydroxytryptophan (5-HTP) caused a significant increase (p less than 0.05) in arterial plasma renin activity (pra) that was abolished when peripheral and central aromatic amino acid decarboxylase activities were inhibited by administration of benserazide, but not reduced when only the peripheral decarboxylase activities were inhibited by administration of carbidopa.	Carbidopa	360-369	renin	Canis lupus familiaris	96-101
6986577-4	1980	The serotonin receptor blocking drug metergoline also abolished the renin response to 5-HTP.	Metergoline	37-48	renin	Canis lupus familiaris	68-73
6986577-4	1980	The serotonin receptor blocking drug metergoline also abolished the renin response to 5-HTP.	5-Hydroxytryptophan	86-91	renin	Canis lupus familiaris	68-73
6986577-9	1980	These data indicate that 5-HTP and L-Tryptophan act on the central nervous system to produce an increase in renin secretion that is mediated via the renal nerves and occurs without a concomitant increase in sympathetic output to the heart or blood vessels.	5-Hydroxytryptophan	25-30	renin	Canis lupus familiaris	108-113
6986577-9	1980	These data indicate that 5-HTP and L-Tryptophan act on the central nervous system to produce an increase in renin secretion that is mediated via the renal nerves and occurs without a concomitant increase in sympathetic output to the heart or blood vessels.	Tryptophan	35-47	renin	Canis lupus familiaris	108-113
6993967-4	1980	PGI2 increased renin secretion rates threefold.	Epoprostenol	0-4	renin	Canis lupus familiaris	15-20
6993967-6	1980	On a molar basis, PGI2 is about 10 times more potent than PGE2 with regard to natriuresis, diuresis and renin release when studied under identical conditions.	Epoprostenol	18-22	renin	Canis lupus familiaris	104-109
6993967-6	1980	On a molar basis, PGI2 is about 10 times more potent than PGE2 with regard to natriuresis, diuresis and renin release when studied under identical conditions.	Dinoprostone	58-62	renin	Canis lupus familiaris	104-109
41666-5	1979	Renin was converted into a higher-molecular-weight form (60 000) by mixing with cytosol in the presence of sodium tetrathionate, a thiol inhibitor.	Tetrathionic Acid	107-127	renin	Canis lupus familiaris	0-5
41666-5	1979	Renin was converted into a higher-molecular-weight form (60 000) by mixing with cytosol in the presence of sodium tetrathionate, a thiol inhibitor.	Sulfhydryl Compounds	131-136	renin	Canis lupus familiaris	0-5
41666-11	1979	The mixture of renin in the granules with fraction A and sodium tetrathionate resulted in the formation of a higher-molecular-weight form of the enzyme, but no change in molecular weight was detected when renin was mixed with fractions B or C and sodium tetrathionate.	Tetrathionic Acid	57-77	renin	Canis lupus familiaris	15-20
41666-11	1979	The mixture of renin in the granules with fraction A and sodium tetrathionate resulted in the formation of a higher-molecular-weight form of the enzyme, but no change in molecular weight was detected when renin was mixed with fractions B or C and sodium tetrathionate.	Tetrathionic Acid	247-267	renin	Canis lupus familiaris	15-20
480187-0	1979	Role of peripheral adrenoreceptors and vasopressin in the suppression of plasma renin activity by L-dopa in carbidopa-treated dogs.	Levodopa	98-104	renin	Canis lupus familiaris	80-85
6991148-6	1980	In addition, increased plasma renin activity produced by dopamine infusion during hemorrhage would tend to offset the expected increases in renal blood flow and sodium excretion.	Dopamine	57-65	renin	Canis lupus familiaris	30-35
6991148-6	1980	In addition, increased plasma renin activity produced by dopamine infusion during hemorrhage would tend to offset the expected increases in renal blood flow and sodium excretion.	Sodium	161-167	renin	Canis lupus familiaris	30-35
483500-3	1979	The administration of indomethacin to the intact, normotensive animals caused the anticipated decrease of prostaglandin E, renin, and renal blood flow.	Indomethacin	22-34	renin	Canis lupus familiaris	123-128
456314-2	1979	N-ethyl maleimide (7.8 mM) yielded renin activity in two high molecular weight (HMW) forms, 65,000 (65K) and 55,000 (55K).	Ethylmaleimide	0-17	renin	Canis lupus familiaris	35-40
464123-3	1979	A time-control group was perfused with normal artificial CSF throughout C, E, and R. High sodium perfusion resulted in a marked natriuresis in each of nine animals and suppression of plasma renin activity.	Sodium	90-96	renin	Canis lupus familiaris	190-195
447846-9	1979	Because either constant RPP or PG inhibition blunted renin release during HH in the setting of beta adrenergic blockade, the present results strongly suggest that the renal baroreceptor, and probably the macula densa mechanism are PG mediated.	Prostaglandins	31-33	renin	Canis lupus familiaris	53-58
232085-1	1979	Sodium depletion was induced in dogs to raise plasma renin activity (PRA) from 1.11 to 26.48 ng/ml/hr.	Sodium	0-6	renin	Canis lupus familiaris	53-58
447846-1	1979	The importance of renal perfusion pressure (RPP), the sympathetic beta adrenergic nervous system and renal prostaglandins (PG) on renin release during a uniform 15-17% reduction in blood pressure by hemorrhage (HH) was studied systematically in anesthetized dogs.	Prostaglandins	123-125	renin	Canis lupus familiaris	130-135
480187-0	1979	Role of peripheral adrenoreceptors and vasopressin in the suppression of plasma renin activity by L-dopa in carbidopa-treated dogs.	Carbidopa	108-117	renin	Canis lupus familiaris	80-85
480187-1	1979	When extracerebral dopa decarboxylase is inhibited by carbidopa, L-dopa lowers plasma renin activity (PRA).	Carbidopa	54-63	renin	Canis lupus familiaris	86-91
480187-1	1979	When extracerebral dopa decarboxylase is inhibited by carbidopa, L-dopa lowers plasma renin activity (PRA).	Levodopa	65-71	renin	Canis lupus familiaris	86-91
501901-0	1979	Inhibition of dog renin activity by pepstatin A.	pepstatin	36-47	renin	Canis lupus familiaris	18-23
501901-2	1979	Pepstatin A inhibited the action of dog renin on homologus substrate.	pepstatin	0-11	renin	Canis lupus familiaris	40-45
501901-5	1979	Dose-dependent hypotensive effect of pepstatin A was observed in rats with sustained increase in blood pressure during continuous infusion of dog renin.	pepstatin	37-48	renin	Canis lupus familiaris	146-151
501901-6	1979	It is concluded that pepstatin A inhibits the dog renin activity in vitro and in vivo.	pepstatin	21-32	renin	Canis lupus familiaris	50-55
501902-2	1979	High molecular weight (HMW) renin fractionated by gel chromatography from crude renal extract prepared with thiol group blockers was converted into normal size renin by acdification, accompanied with an increase in renin activity by about 50%.	Sulfhydryl Compounds	108-113	renin	Canis lupus familiaris	28-33
501902-2	1979	High molecular weight (HMW) renin fractionated by gel chromatography from crude renal extract prepared with thiol group blockers was converted into normal size renin by acdification, accompanied with an increase in renin activity by about 50%.	Sulfhydryl Compounds	108-113	renin	Canis lupus familiaris	160-165
501902-2	1979	High molecular weight (HMW) renin fractionated by gel chromatography from crude renal extract prepared with thiol group blockers was converted into normal size renin by acdification, accompanied with an increase in renin activity by about 50%.	Sulfhydryl Compounds	108-113	renin	Canis lupus familiaris	160-165
501902-4	1979	Renin and renin binding substance could combine into HMW renin at neutral pH in the presence of thiol group blockers and renin activity decreased.	Sulfhydryl Compounds	96-101	renin	Canis lupus familiaris	0-5
501902-4	1979	Renin and renin binding substance could combine into HMW renin at neutral pH in the presence of thiol group blockers and renin activity decreased.	Sulfhydryl Compounds	96-101	renin	Canis lupus familiaris	10-15
501902-4	1979	Renin and renin binding substance could combine into HMW renin at neutral pH in the presence of thiol group blockers and renin activity decreased.	Sulfhydryl Compounds	96-101	renin	Canis lupus familiaris	57-62
501902-4	1979	Renin and renin binding substance could combine into HMW renin at neutral pH in the presence of thiol group blockers and renin activity decreased.	Sulfhydryl Compounds	96-101	renin	Canis lupus familiaris	57-62
447846-4	1979	This increase in renin release during HH was not abolished by any single maneuver alone including beta adrenergic blockade with d,l-propranolol (n = 6), renal PG inhibition with indomethacin (n = 7), or control of RPP (n = 6).	Propranolol	128-143	renin	Canis lupus familiaris	17-22
447846-4	1979	This increase in renin release during HH was not abolished by any single maneuver alone including beta adrenergic blockade with d,l-propranolol (n = 6), renal PG inhibition with indomethacin (n = 7), or control of RPP (n = 6).	Prostaglandins	159-161	renin	Canis lupus familiaris	17-22
447846-4	1979	This increase in renin release during HH was not abolished by any single maneuver alone including beta adrenergic blockade with d,l-propranolol (n = 6), renal PG inhibition with indomethacin (n = 7), or control of RPP (n = 6).	Indomethacin	178-190	renin	Canis lupus familiaris	17-22
371855-0	1979	Prostaglandins and renin release: the effect of PGI2, PGE2, and 13,14-dihydro PGE2 on the baroreceptor mechanism of renin release in the dog.	13,14-dihydroprostaglandin E2	64-82	renin	Canis lupus familiaris	116-121
443450-1	1979	Previous work from our laboratory has shown that physiological increments of circulating epinephrine concentration increase plasma renin activity (PRA) by an extrarenal beta-receptor mechanism.	Epinephrine	89-100	renin	Canis lupus familiaris	131-136
371855-1	1979	We compared the ability of the vasodilator prostaglandins PGI2, PGE2, and 13,14-dihydro PGE2 to release renin when infused into the denervated, nonfiltering canine kidney in vivo.	Prostaglandins	43-57	renin	Canis lupus familiaris	104-109
477626-1	1979	Intravenous infusion of somatostatin in mongrel dogs caused a significant decrease in the peripheral plasma renin activity (PRA) enhanced by pentobarbital sodium anesthesia or furosemide treatment.	Pentobarbital	141-161	renin	Canis lupus familiaris	108-113
371855-1	1979	We compared the ability of the vasodilator prostaglandins PGI2, PGE2, and 13,14-dihydro PGE2 to release renin when infused into the denervated, nonfiltering canine kidney in vivo.	Epoprostenol	58-62	renin	Canis lupus familiaris	104-109
371855-1	1979	We compared the ability of the vasodilator prostaglandins PGI2, PGE2, and 13,14-dihydro PGE2 to release renin when infused into the denervated, nonfiltering canine kidney in vivo.	Dinoprostone	64-68	renin	Canis lupus familiaris	104-109
371855-1	1979	We compared the ability of the vasodilator prostaglandins PGI2, PGE2, and 13,14-dihydro PGE2 to release renin when infused into the denervated, nonfiltering canine kidney in vivo.	13,14-dihydroprostaglandin E2	74-92	renin	Canis lupus familiaris	104-109
371855-3	1979	All the prostaglandins tested were capable of stimulating renin secretion, with the scale of potency being 13,14-dihydro PGE2 greater than PGI2 greater than PGE2; papaverine had no effect on renin secretion.	Prostaglandins	8-22	renin	Canis lupus familiaris	58-63
371855-4	1979	These results indicate that both PGE2 and PGI2 can stimulate renin secretion but that vasodilation per se is not a stimulus.	Dinoprostone	33-37	renin	Canis lupus familiaris	61-66
371855-4	1979	These results indicate that both PGE2 and PGI2 can stimulate renin secretion but that vasodilation per se is not a stimulus.	Epoprostenol	42-46	renin	Canis lupus familiaris	61-66
371855-8	1979	Therefore, both PGE2 and PGI2 are candidates for the endogenous prostaglandin responsible for stimulating renin secretion.	Dinoprostone	16-20	renin	Canis lupus familiaris	106-111
371855-8	1979	Therefore, both PGE2 and PGI2 are candidates for the endogenous prostaglandin responsible for stimulating renin secretion.	Epoprostenol	25-29	renin	Canis lupus familiaris	106-111
371855-8	1979	Therefore, both PGE2 and PGI2 are candidates for the endogenous prostaglandin responsible for stimulating renin secretion.	Prostaglandins	64-77	renin	Canis lupus familiaris	106-111
477626-1	1979	Intravenous infusion of somatostatin in mongrel dogs caused a significant decrease in the peripheral plasma renin activity (PRA) enhanced by pentobarbital sodium anesthesia or furosemide treatment.	Furosemide	176-186	renin	Canis lupus familiaris	108-113
219717-2	1979	Unilateral alpha-adrenoceptor blockade with phenoxybenzamine resulted in an increase in basal renal blood flow, a depression of basal renin release, and an abolition of the responses to BCO in the treated kidney.	Phenoxybenzamine	44-60	renin	Canis lupus familiaris	134-139
219717-5	1979	Administration of propranolol to the nonblocked kidney prevented the release of renin but not the hemodynamic changes resulting from BCO.	Propranolol	18-29	renin	Canis lupus familiaris	80-85
219717-7	1979	A step in the renin release mechanism subsequent to the alpha-adrenoceptor-mediated changes in sensitive to propranolol.	Propranolol	108-119	renin	Canis lupus familiaris	14-19
475475-0	1979	Effect of intravenous or intracisternal clonidine and propranolol on plasma renin.	Clonidine	40-49	renin	Canis lupus familiaris	76-81
455142-0	1979	Effect of pentobarbital anesthesia and laparotomy on plasma renin activity in the dog.	Pentobarbital	10-23	renin	Canis lupus familiaris	60-65
475475-0	1979	Effect of intravenous or intracisternal clonidine and propranolol on plasma renin.	Propranolol	54-65	renin	Canis lupus familiaris	76-81
481661-9	1979	Arterial plasma renin activity was 3.29 +/- 0.83 ng/ml/h before and was 20.97 +/- 7.78 ng/ml/h after 100 min of infusion of ACH (p less than 0.025).	Acetylcholine	124-127	renin	Canis lupus familiaris	16-21
426082-3	1979	Elevation of epinephrine concentration to over 2,000 pg/ml by IVC infusion resulted in a sustained 3.5-fold increase in plasma renin activity (PRA), with only a transient decrease in arterial blood pressure.	Epinephrine	13-24	renin	Canis lupus familiaris	127-132
759047-0	1979	Effect of dithiothreitol of the reaction of renin and angiotensinogen.	Dithiothreitol	10-24	renin	Canis lupus familiaris	44-49
759201-0	1979	Effect of prostaglandin endoperoxide analogue on canine renal function, hemodynamics and renin release.	Prostaglandin Endoperoxides	10-36	renin	Canis lupus familiaris	89-94
759201-5	1979	EPA caused a significant increase in renin release that was completely blocked by prior treatment with indomethacin.	Indomethacin	103-115	renin	Canis lupus familiaris	37-42
759201-7	1979	Renin release is not a direct effect of EPA but probably is secondary to an endogenously generated prostaglandin.	Prostaglandins	99-112	renin	Canis lupus familiaris	0-5
232613-0	1979	Effect on renal function and renin secretion of noradrenaline infused into the renal artery.	Norepinephrine	48-61	renin	Canis lupus familiaris	29-34
232613-3	1979	Noradrenaline infusion resulted in a significant elevation of renin secretion associated with marked vasoconstriction.	Norepinephrine	0-13	renin	Canis lupus familiaris	62-67
232613-6	1979	The simultaneous infusion of noradrenaline enhanced renin release without affecting renal haemodynamics or reducing Na-excretion.	Norepinephrine	29-42	renin	Canis lupus familiaris	52-57
396760-0	1979	Species differences in the effect of isoproterenol and pindolol on renin release in vitro.	Isoproterenol	37-50	renin	Canis lupus familiaris	67-72
396760-0	1979	Species differences in the effect of isoproterenol and pindolol on renin release in vitro.	Pindolol	55-63	renin	Canis lupus familiaris	67-72
396760-1	1979	The effects of selective beta adrenergic receptor stimulation with isoproterenol (3 X 10(-8) M) and of beta adrenergic blockade with pindolol (3 X 10(-5) M) on the renin release in vitro were investigated in incubated canine and rat kidney slices.	Pindolol	133-141	renin	Canis lupus familiaris	164-169
396760-3	1979	Isoproterenol in a concentration of 3 X 10(-8) M brought about a significant increase in the renin content of the incubation media as well as the tissue slices obtained from canine kidney, however, there was no change in these parameters under similar conditions if rat kidneys were incubated.	Isoproterenol	0-13	renin	Canis lupus familiaris	93-98
514427-1	1979	The effect of indomethacin on plasma renin activity (PRA) and renal function was examined in conscious dogs with chronic renovascular hypertension before or after volume expansion.	Indomethacin	14-26	renin	Canis lupus familiaris	37-42
481661-10	1979	The data suggest that prostaglandins are involved in the sodium excretion and the renin secretion produced by acetylcholine.	Prostaglandins	22-36	renin	Canis lupus familiaris	82-87
481661-10	1979	The data suggest that prostaglandins are involved in the sodium excretion and the renin secretion produced by acetylcholine.	Acetylcholine	110-123	renin	Canis lupus familiaris	82-87
214314-1	1978	The effects of glucagon alone or in combination with theophylline on renin section were studied in relation to renal hemodynamic responses in anesthetized dogs.	Glucagon	15-23	renin	Canis lupus familiaris	69-74
366108-0	1978	The effect of increasing the plasma magnesium concentration on renin release from the dog"s kidney: interactions with calcium and sodium.	Magnesium	36-45	renin	Canis lupus familiaris	63-68
366108-7	1978	Infusions of MgCl2 solutions into the renal artery which raised the renal plasma Mg concentration (PMg) by 0.1-2 m-mole.1.-1 provoked a concentration-related increase in renin release into plasma.	Magnesium Chloride	13-18	renin	Canis lupus familiaris	170-175
366108-7	1978	Infusions of MgCl2 solutions into the renal artery which raised the renal plasma Mg concentration (PMg) by 0.1-2 m-mole.1.-1 provoked a concentration-related increase in renin release into plasma.	Magnesium	13-15	renin	Canis lupus familiaris	170-175
366108-7	1978	Infusions of MgCl2 solutions into the renal artery which raised the renal plasma Mg concentration (PMg) by 0.1-2 m-mole.1.-1 provoked a concentration-related increase in renin release into plasma.	N-PYRIDOXYL-2-METHYL-L-GLUTAMIC ACID-5'-MONOPHOSPHATE	99-102	renin	Canis lupus familiaris	170-175
366108-18	1978	The possibility is discussed that Mg is reabsorbed from the tubular into the interstitial fluid where it antagonizes the action(s) of Ca on renin release from the juxtaglomerular cells.	Magnesium	34-36	renin	Canis lupus familiaris	140-145
220888-1	1979	The relation of the renin-angiotensin-aldosterone system to sodium retention was studied in dogs with an aortic-caval fistula and high output failure by administering orally the new converting enzyme inhibitor SQ 14225.	Sodium	60-66	renin	Canis lupus familiaris	20-25
747665-4	1978	Though the molecular weight of renin in kidney-cortex homogenate was 43,000, it was completely converted into high-molecular-weight renin in the presence of substances that react with thiol groups.	Sulfhydryl Compounds	184-189	renin	Canis lupus familiaris	31-36
747665-4	1978	Though the molecular weight of renin in kidney-cortex homogenate was 43,000, it was completely converted into high-molecular-weight renin in the presence of substances that react with thiol groups.	Sulfhydryl Compounds	184-189	renin	Canis lupus familiaris	132-137
741539-3	1978	The individual effects of chlorothiazide, furosemide, and mannitol on renin activity in renal lymph have been studied in dogs.	Mannitol	58-66	renin	Canis lupus familiaris	70-75
741539-4	1978	Elevation of renin activity in lymph is noted following infusion with either chlorothiazide or furosemide, while a reduction of renin activity in renal lymph is noted after mannitol infusion.	Chlorothiazide	77-91	renin	Canis lupus familiaris	13-18
741539-4	1978	Elevation of renin activity in lymph is noted following infusion with either chlorothiazide or furosemide, while a reduction of renin activity in renal lymph is noted after mannitol infusion.	Furosemide	95-105	renin	Canis lupus familiaris	13-18
741539-4	1978	Elevation of renin activity in lymph is noted following infusion with either chlorothiazide or furosemide, while a reduction of renin activity in renal lymph is noted after mannitol infusion.	Mannitol	173-181	renin	Canis lupus familiaris	128-133
741539-5	1978	The importance of elevated sodium levels in the proximal end of the distal tubule and its effects on renin release in kidney interstitium is stressed.	Sodium	27-33	renin	Canis lupus familiaris	101-106
711860-4	1978	Plasma renin activity increased from 2.3+/-0.4 to 4.9+/-0.8 ng/ml per h during 8% oxygen breathing, and from 2.8+/-0.4 to 8.4+/-1.8 ng/ml per h during 5% oxygen breathing.	Oxygen	82-88	renin	Canis lupus familiaris	7-12
711860-4	1978	Plasma renin activity increased from 2.3+/-0.4 to 4.9+/-0.8 ng/ml per h during 8% oxygen breathing, and from 2.8+/-0.4 to 8.4+/-1.8 ng/ml per h during 5% oxygen breathing.	Oxygen	154-160	renin	Canis lupus familiaris	7-12
214314-2	1978	The intrarenal infusion of glucagon (0.5 microgram/kg/min) increased heart rate, renal blood flow, glomerular filtration rate and urine flow without any effect on renin secretion, but at a higher dose (1.0 microgram/kg/min) it increased renin secretion significantly.	Glucagon	27-35	renin	Canis lupus familiaris	237-242
703525-0	1978	Role of prostaglandins in the control of renin secretion in the dog (II).	Prostaglandins	8-22	renin	Canis lupus familiaris	41-46
214314-3	1978	Theophylline (0.1 mg/kg/min) did not affect renal hemodynamics but caused a slight increase in renin secretion after 30--60 min infusion.	Theophylline	0-12	renin	Canis lupus familiaris	95-100
214314-4	1978	The combined infusion of glucagon (0.5 microgram/kg/min) with theophylline (0.1 mg/kg/min) increased renin secretion markedly, although it produced renal hemodynamic changes similar to those induced by glucagon alone.	Glucagon	25-33	renin	Canis lupus familiaris	101-106
214314-4	1978	The combined infusion of glucagon (0.5 microgram/kg/min) with theophylline (0.1 mg/kg/min) increased renin secretion markedly, although it produced renal hemodynamic changes similar to those induced by glucagon alone.	Theophylline	62-74	renin	Canis lupus familiaris	101-106
214314-6	1978	It is suggested that the increase in renin secretion caused by the combined infusion of glucagon and theophylline resulted mainly from an increase in cyclic AMP in the juxtaglomerular cells, and not from stimulation of beta-adrenoceptors.	Glucagon	88-96	renin	Canis lupus familiaris	37-42
214314-6	1978	It is suggested that the increase in renin secretion caused by the combined infusion of glucagon and theophylline resulted mainly from an increase in cyclic AMP in the juxtaglomerular cells, and not from stimulation of beta-adrenoceptors.	Theophylline	101-113	renin	Canis lupus familiaris	37-42
214314-6	1978	It is suggested that the increase in renin secretion caused by the combined infusion of glucagon and theophylline resulted mainly from an increase in cyclic AMP in the juxtaglomerular cells, and not from stimulation of beta-adrenoceptors.	Cyclic AMP	150-160	renin	Canis lupus familiaris	37-42
568077-0	1978	[Change in renin activity in the venous blood plasma of dogs under the influence of furosemide, novurit, ethacrynic acid and mannitol].	mercurophylline	96-103	renin	Canis lupus familiaris	11-16
744127-5	1978	These findings are compatible with the thesis that an increased distal tubular load of sodium stimulates renin release and suggest that the increased distal sodium absorption after the proximal effects of PTH may be regulated by the renin-angiotensin-aldosterone system.	Sodium	87-93	renin	Canis lupus familiaris	105-110
568077-0	1978	[Change in renin activity in the venous blood plasma of dogs under the influence of furosemide, novurit, ethacrynic acid and mannitol].	Furosemide	84-94	renin	Canis lupus familiaris	11-16
568077-0	1978	[Change in renin activity in the venous blood plasma of dogs under the influence of furosemide, novurit, ethacrynic acid and mannitol].	Ethacrynic Acid	105-120	renin	Canis lupus familiaris	11-16
568077-0	1978	[Change in renin activity in the venous blood plasma of dogs under the influence of furosemide, novurit, ethacrynic acid and mannitol].	Mannitol	125-133	renin	Canis lupus familiaris	11-16
568077-2	1978	A comparison of the plasms renin activity as against changes in the volume of plasma and CBV occurring under the effect of saluretics gives an idea on the factorc regulating the renin secretion by the kidneys.	saluretics	123-133	renin	Canis lupus familiaris	178-183
744127-5	1978	These findings are compatible with the thesis that an increased distal tubular load of sodium stimulates renin release and suggest that the increased distal sodium absorption after the proximal effects of PTH may be regulated by the renin-angiotensin-aldosterone system.	Sodium	87-93	renin	Canis lupus familiaris	233-238
744127-5	1978	These findings are compatible with the thesis that an increased distal tubular load of sodium stimulates renin release and suggest that the increased distal sodium absorption after the proximal effects of PTH may be regulated by the renin-angiotensin-aldosterone system.	Sodium	157-163	renin	Canis lupus familiaris	233-238
744084-6	1978	These data indicate that the effects of isoproterenol on drinking, urine flow, and vasopressin secretion are mediated via the renin-angiotensin system.	Isoproterenol	40-53	renin	Canis lupus familiaris	126-131
744259-0	1978	Effect of prostaglandin A on renin secretion in the dog.	Prostaglandins A	10-25	renin	Canis lupus familiaris	29-34
744259-1	1978	The role of PGA on the release of renin in the anesthetized dog has been studied.	Prostaglandins A	12-15	renin	Canis lupus familiaris	34-39
744259-2	1978	The infusion of prostaglandin for 60 minutes at a dose unable to cause pressor modifications (2 microgram/kg/min) was shown to increase the plasma renin activity (PRA); this effect was inhibited by propranolol and strengthened by aminophylline.	Prostaglandins	16-29	renin	Canis lupus familiaris	147-152
744259-2	1978	The infusion of prostaglandin for 60 minutes at a dose unable to cause pressor modifications (2 microgram/kg/min) was shown to increase the plasma renin activity (PRA); this effect was inhibited by propranolol and strengthened by aminophylline.	Propranolol	198-209	renin	Canis lupus familiaris	147-152
713169-0	1978	[Studies on hypertension: I) The effects of angiotensin II and norepinephrine infusion on renal hemodynamics and renin angiotensin system in anesthetized dogs.	Norepinephrine	63-77	renin	Canis lupus familiaris	113-118
27375-2	1978	An increase in plasma renin concentration which accompanied hypercapnia in untreated dogs was completely suppressed by pretreatment with guanethidine or propranolol.	Guanethidine	137-149	renin	Canis lupus familiaris	22-27
30849-5	1978	The response of elevated plasma renin activity during 4% and 8% CO2 inhalation was not different between the control and propranolol groups.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	64-67	renin	Canis lupus familiaris	32-37
30849-6	1978	However, the increase of plasma renin activity in the control group was greater than that of the propranolol treated group during 12% CO2 inhalation.	Propranolol	97-108	renin	Canis lupus familiaris	32-37
30849-6	1978	However, the increase of plasma renin activity in the control group was greater than that of the propranolol treated group during 12% CO2 inhalation.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	134-137	renin	Canis lupus familiaris	32-37
30849-7	1978	It is suggested that activation of beta adrenergic receptors is not the sole factor in renin control during acute respiratory acidosis, although these receptors do mediate a significant fraction of the renin response to CO2 inhalation.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	220-223	renin	Canis lupus familiaris	202-207
27375-2	1978	An increase in plasma renin concentration which accompanied hypercapnia in untreated dogs was completely suppressed by pretreatment with guanethidine or propranolol.	Propranolol	153-164	renin	Canis lupus familiaris	22-27
659580-0	1978	Renin-angiotensin system inhibition in conscious sodium-depleted dogs.	Sodium	49-55	renin	Canis lupus familiaris	0-5
25587-0	1978	Mechanisms of enhanced renin secretion during CO2 retention in dogs.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	46-49	renin	Canis lupus familiaris	23-28
674817-3	1978	Following acute myocardial infarction, significant correlations were found to exist between plasma norepinephrine and plasma renin activity and between the levels of these vasoactive substances and the measured indices of ischemic damage.	Norepinephrine	99-113	renin	Canis lupus familiaris	125-130
641142-4	1978	Acute and chronic sodium depletion increased plasma renin activity (PRA) and blunted the RVR to AII, while acute sodium repletion and chronic sodium excess plus desoxycorticosterone acetate decreased PRA and enhanced the RVR to AII.	Sodium	18-24	renin	Canis lupus familiaris	52-57
641152-0	1978	The role of renal nerves and prostaglandins in control of renal hemodynamics and plasma renin activity during hypotensive hemorrhage in the dog.	Prostaglandins	29-43	renin	Canis lupus familiaris	88-93
755346-0	1978	Effect of papaverine on renin release in dogs in vivo and in vitro.	Papaverine	10-20	renin	Canis lupus familiaris	24-29
650466-2	1978	Intracranial injections of the individual components of the renin-angiotensin system caused drinking in water-replete dogs.	Water	104-109	renin	Canis lupus familiaris	60-65
650466-14	1978	Dog renin substrate and synthetic renin substrate, injected intracranially in a dose of 10(-10) mole, produced similar intakes of water but these amounts were very much less than the volume drunk in response to the same dose of angiotensin II.	Water	130-135	renin	Canis lupus familiaris	4-9
650466-14	1978	Dog renin substrate and synthetic renin substrate, injected intracranially in a dose of 10(-10) mole, produced similar intakes of water but these amounts were very much less than the volume drunk in response to the same dose of angiotensin II.	Water	130-135	renin	Canis lupus familiaris	34-39
620441-0	1978	Mechanism of suppression of renin secretion by clonidine in the dog.	Clonidine	47-56	renin	Canis lupus familiaris	28-33
620441-1	1978	The mechanism by which clonidine suppresses renin secretion was investigated in pentobarbital-anesthetized dogs in which renal perfusion pressure was controlled by means of an aortic clamp.	Clonidine	23-32	renin	Canis lupus familiaris	44-49
620441-2	1978	Clonidine (30 microgram/kg, iv) lowered mean arterial pressure (MAP) from 124 +/- 8 to 104 +/- 4 mm Hg (P less than 0.01) and reduced plasma renin activity (PRA) to 32 +/- 4 percent of the control value (P less than 0.01) after 60 minutes.	Clonidine	0-9	renin	Canis lupus familiaris	141-146
620441-8	1978	Taken together, these data support the hypothesis that the inhibition of renin secretion by clonidine results from a centrally mediated decrease in sympathetic neural activity.	Clonidine	92-101	renin	Canis lupus familiaris	73-78
755346-4	1978	Renin activity (PRA) of arterial blood and renal venous blood, veno-arterious PRA-difference and renin secretion increased significantly after papaverine infusion.	Papaverine	143-153	renin	Canis lupus familiaris	0-5
755346-4	1978	Renin activity (PRA) of arterial blood and renal venous blood, veno-arterious PRA-difference and renin secretion increased significantly after papaverine infusion.	Papaverine	143-153	renin	Canis lupus familiaris	97-102
755346-6	1978	Papaverine caused a significant increase in renin release and in tissue cAMP concentration.	Papaverine	0-10	renin	Canis lupus familiaris	44-49
755346-7	1978	This supports the assumption that the increase in renin secretion might be due to a direct effect on the juxtaglomerular apparatus, by blocking phosphodiesterase activity and by increasing the renal cAMP level.	Cyclic AMP	199-203	renin	Canis lupus familiaris	50-55
623259-1	1978	Intrarenal arterial infusions of sodium and potassium salts with anions other than chloride were given to evaluate the role of the chloride ion in influencing renin secretion (RS).	Chlorides	131-139	renin	Canis lupus familiaris	159-164
623259-0	1978	Effects of sodium and potassium salts with anions other than chloride on renin secretion in the dog.	potassium salts	22-37	renin	Canis lupus familiaris	73-78
623259-10	1978	The results with sodium lactate favor a role for sodium compared with chloride in mediating the decreased renin release, but there are other possible interpretations which have been discussed.	Chlorides	70-78	renin	Canis lupus familiaris	106-111
668387-0	1978	Plasma renin activity in acute renal failure induced by norepinephrine infusion in unilaterally nephrectomized dogs.	Norepinephrine	56-70	renin	Canis lupus familiaris	7-12
202430-12	1978	The possibility is discussed that propranolol may depress renin release in the dog by an action other than that of blocking beta-adrenoreceptors.	Propranolol	34-45	renin	Canis lupus familiaris	58-63
619126-5	1978	A transient rise in plasma renin activity was measured only after the higher dose of bumetanide.	Bumetanide	85-95	renin	Canis lupus familiaris	27-32
206850-1	1978	To determine whether the inhibitory effect of clonidine (CLON) on renin secretion is due in part to a direct action on the kidneys or due entirely to an action on the brain, the drug was administered intravenously in a dose of 30 microgram/kg to dogs in which the spinal cord had been transected in the cervical region.	Clonidine	46-55	renin	Canis lupus familiaris	66-71
909077-2	1977	PE-104 inhibited the reaction between dog renal renin and homologous plasma angiotensinogen.	PE 104	0-6	renin	Canis lupus familiaris	48-53
902149-0	1977	Effect of propranolol on renin release in the dog.	Propranolol	10-21	renin	Canis lupus familiaris	25-30
902149-1	1977	Infusion of d,l-propranolol in both anesthetized and conscious dogs caused decreases in heart rate (HR), plasma renin activity (PRA), and plasma aldosterone.	Propranolol	12-27	renin	Canis lupus familiaris	112-117
902149-6	1977	The data suggest that propranolol at the dose administered suppresses renin and aldosterone secretion in unstimulated dogs.	Propranolol	22-33	renin	Canis lupus familiaris	70-75
886921-0	1977	Suppression of renin secretion by propranolol in salt-depleted dogs.	Propranolol	34-45	renin	Canis lupus familiaris	15-20
884622-0	1977	Increased circulating plasma catecholamines and plasma renin activity in dogs after chemical sympathectomy with 6-hydroxydopamine.	Oxidopamine	112-129	renin	Canis lupus familiaris	55-60
884622-3	1977	Significant increases in plasma glucose and lactate concentrations, circulating plasma catecholamines, and plasma renin activity were found 24 h after 6-OHDA treatment.	Oxidopamine	151-157	renin	Canis lupus familiaris	114-119
884622-5	1977	Plasma renin activity remained elevated during the 1st week after 6-OHDA treatment and returned to control levels during the 2nd week.	Oxidopamine	66-72	renin	Canis lupus familiaris	7-12
870226-0	1977	Role of the renin-angiotensin system in the regulation of aldosterone biosynthesis and arterial pressure during sodium deficiency.	Aldosterone	58-69	renin	Canis lupus familiaris	12-17
870226-0	1977	Role of the renin-angiotensin system in the regulation of aldosterone biosynthesis and arterial pressure during sodium deficiency.	Sodium	112-118	renin	Canis lupus familiaris	12-17
870226-7	1977	The intrinsic agonistic properties of the angiotensin II inhibitory analogues on the adrenal cortex negate their use for defining the role of the renin-angiotensin system in the regulation of aldosterone biosynthesis during sodium deficiency.	Aldosterone	192-203	renin	Canis lupus familiaris	146-151
870226-8	1977	The precipitous fall in aldosterone secretion and arterial blood pressure during long-term infusion of angiotensin I-converting enzyme inhibitor demonstrates the importance of the renin-angiotensin system in mediating aldosterone biosynthesis during sodium deficiency and the essential role of the renin-angiotensin-aldosterone system in the regulation of arterial pressure during sodium deficiency.	Sodium	250-256	renin	Canis lupus familiaris	180-185
870226-8	1977	The precipitous fall in aldosterone secretion and arterial blood pressure during long-term infusion of angiotensin I-converting enzyme inhibitor demonstrates the importance of the renin-angiotensin system in mediating aldosterone biosynthesis during sodium deficiency and the essential role of the renin-angiotensin-aldosterone system in the regulation of arterial pressure during sodium deficiency.	Sodium	381-387	renin	Canis lupus familiaris	180-185
850131-3	1977	Indomethacin given 60 minutes after endotoxin caused an elevation of blood pressure and a 50% decrease in plasma renin activity.	Indomethacin	0-12	renin	Canis lupus familiaris	113-118
850131-4	1977	Pretreatment with indomethacin markedly attenuated both the hemodynamic changes and the rise in plasma renin activity caused by endotoxin administration.	Indomethacin	18-30	renin	Canis lupus familiaris	103-108
192922-4	1977	Intrarenal arterial infusion of norepinephrine at a control pressure increased a renin secretion.	Norepinephrine	32-46	renin	Canis lupus familiaris	81-86
192922-5	1977	However, norepinephrine infusion at a reduced pressure suppressed the renin release with a recovery of the vascular resistance to the control level.	Norepinephrine	9-23	renin	Canis lupus familiaris	70-75
192922-10	1977	3) Intrarenal arterial infusion of cAMP and DbcAMP resulted in a significant increase of renin release.	Cyclic AMP	35-39	renin	Canis lupus familiaris	89-94
192922-10	1977	3) Intrarenal arterial infusion of cAMP and DbcAMP resulted in a significant increase of renin release.	Bucladesine	44-50	renin	Canis lupus familiaris	89-94
192922-12	1977	These data suggested that a beta-adrenergic receptor-adenyl cyclase-cAMP system was involved in the control of renin secretion, and that since the intracellular effect of cAMP was partly related to the change of intracellular Ca distribution, its change resulted in an increase in renin secretion.	Cyclic AMP	68-72	renin	Canis lupus familiaris	111-116
192922-12	1977	These data suggested that a beta-adrenergic receptor-adenyl cyclase-cAMP system was involved in the control of renin secretion, and that since the intracellular effect of cAMP was partly related to the change of intracellular Ca distribution, its change resulted in an increase in renin secretion.	Cyclic AMP	68-72	renin	Canis lupus familiaris	281-286
192922-12	1977	These data suggested that a beta-adrenergic receptor-adenyl cyclase-cAMP system was involved in the control of renin secretion, and that since the intracellular effect of cAMP was partly related to the change of intracellular Ca distribution, its change resulted in an increase in renin secretion.	Cyclic AMP	171-175	renin	Canis lupus familiaris	111-116
192922-12	1977	These data suggested that a beta-adrenergic receptor-adenyl cyclase-cAMP system was involved in the control of renin secretion, and that since the intracellular effect of cAMP was partly related to the change of intracellular Ca distribution, its change resulted in an increase in renin secretion.	Cyclic AMP	171-175	renin	Canis lupus familiaris	281-286
189553-3	1977	Glucagon infusion does not consistently change plasma renin activity in non-pre-treated dogs, while the renin secretion is almost totally blocked when glucagon is administered to dogs that are pre-treated with indomethacin.	Glucagon	151-159	renin	Canis lupus familiaris	104-109
189553-3	1977	Glucagon infusion does not consistently change plasma renin activity in non-pre-treated dogs, while the renin secretion is almost totally blocked when glucagon is administered to dogs that are pre-treated with indomethacin.	Indomethacin	210-222	renin	Canis lupus familiaris	104-109
191213-4	1977	Dogs on approximately equal to 5 mEq/day of sodium showed significant increases in plasma renin activity (PRA) with intrarenal infusion of the peptides, unmasking a negative feedback inhibition of renin release by angiotensin II.	Sodium	44-50	renin	Canis lupus familiaris	90-95
191213-4	1977	Dogs on approximately equal to 5 mEq/day of sodium showed significant increases in plasma renin activity (PRA) with intrarenal infusion of the peptides, unmasking a negative feedback inhibition of renin release by angiotensin II.	Sodium	44-50	renin	Canis lupus familiaris	197-202
625577-1	1978	Assessment of renin secretion following infusion of PGI2,E2 and D2 into the renal artery of anesthetized dogs.	Epoprostenol	52-56	renin	Canis lupus familiaris	14-19
625577-2	1978	The influence of intra-renal infusions of prostaglandin (PG) I2, PGE2 and PGD2 on renin secretion and renal blood flow was investigated in renally denervated, beta-adrenergic blocked, indomethacin treated dogs with unilateral nephrectomy.	Epoprostenol	42-63	renin	Canis lupus familiaris	82-87
625577-2	1978	The influence of intra-renal infusions of prostaglandin (PG) I2, PGE2 and PGD2 on renin secretion and renal blood flow was investigated in renally denervated, beta-adrenergic blocked, indomethacin treated dogs with unilateral nephrectomy.	Prostaglandin D2	74-78	renin	Canis lupus familiaris	82-87
625577-4	1978	Renin secretory rates increased significantly with both PGI2 and PGE2 at the 10(-8) g/kg/min and 10(-7) g/kg/min infusion rates in a dose dependent manner.	Epoprostenol	56-60	renin	Canis lupus familiaris	0-5
625577-4	1978	Renin secretory rates increased significantly with both PGI2 and PGE2 at the 10(-8) g/kg/min and 10(-7) g/kg/min infusion rates in a dose dependent manner.	Dinoprostone	65-69	renin	Canis lupus familiaris	0-5
625577-7	1978	These findings suggest that PGI2 should be included among the cyclooxygenase derived metabolites of arachidonic acid to be considered as possible mediators of renin release.	Epoprostenol	28-32	renin	Canis lupus familiaris	159-164
625577-7	1978	These findings suggest that PGI2 should be included among the cyclooxygenase derived metabolites of arachidonic acid to be considered as possible mediators of renin release.	Arachidonic Acid	100-116	renin	Canis lupus familiaris	159-164
200948-0	1977	Effects of dibutyryl cyclic AMP and propranolol on renin secretion in dogs.	Bucladesine	11-31	renin	Canis lupus familiaris	51-56
200948-0	1977	Effects of dibutyryl cyclic AMP and propranolol on renin secretion in dogs.	Propranolol	36-47	renin	Canis lupus familiaris	51-56
910953-5	1977	This superimposed sodium depletion (negative sodium balance of 137 +/- 17 meq) increased plasma renin activity 3-5 times but did not change arterial pressure or heart rate.	Sodium	18-24	renin	Canis lupus familiaris	96-101
910953-5	1977	This superimposed sodium depletion (negative sodium balance of 137 +/- 17 meq) increased plasma renin activity 3-5 times but did not change arterial pressure or heart rate.	Sodium	45-51	renin	Canis lupus familiaris	96-101
888960-5	1977	The augmented release of renin during volume depletion was virtually abolished by injection of cryptenamine (2 microgram/kg) into the main left coronary artery, falling from 1,971 to 269 ng/min by 4 min after the cryptenamine injection.	Protoveratrines	95-107	renin	Canis lupus familiaris	25-30
888960-5	1977	The augmented release of renin during volume depletion was virtually abolished by injection of cryptenamine (2 microgram/kg) into the main left coronary artery, falling from 1,971 to 269 ng/min by 4 min after the cryptenamine injection.	Protoveratrines	213-225	renin	Canis lupus familiaris	25-30
874815-0	1977	Effect of L-dopa on plasma renin activity with and without inhibition of extracerebral dopa decarboxylase in dogs.	Levodopa	10-16	renin	Canis lupus familiaris	27-32
874815-2	1977	Plasma renin activity (PRA) was measured after intravenous administration of L-dopa with and without prior inhibition of extracerebral dopa decarboxylase by carbidopa (MK-486) in pentobarbital-anesthetized dogs in which changes in renal perfusion pressure were minimized by means of a suprarenal aortic clamp.	Levodopa	77-83	renin	Canis lupus familiaris	7-12
874815-2	1977	Plasma renin activity (PRA) was measured after intravenous administration of L-dopa with and without prior inhibition of extracerebral dopa decarboxylase by carbidopa (MK-486) in pentobarbital-anesthetized dogs in which changes in renal perfusion pressure were minimized by means of a suprarenal aortic clamp.	Carbidopa	168-174	renin	Canis lupus familiaris	7-12
874815-2	1977	Plasma renin activity (PRA) was measured after intravenous administration of L-dopa with and without prior inhibition of extracerebral dopa decarboxylase by carbidopa (MK-486) in pentobarbital-anesthetized dogs in which changes in renal perfusion pressure were minimized by means of a suprarenal aortic clamp.	Pentobarbital	179-192	renin	Canis lupus familiaris	7-12
874815-12	1977	These data suggest that catecholamines formed within the central nervous system can act to lower renin secretion as well as blood pressure.	Catecholamines	24-38	renin	Canis lupus familiaris	97-102
852103-0	1977	Role of prostaglandins in the control of renin secretion in the dog.	Prostaglandins	8-22	renin	Canis lupus familiaris	41-46
852103-1	1977	Infusion of indomethacin into anesthetized, salt-depleted dogs cuased an increase in mean arterial blood pressure (MABP), and decreases in heart rate (HR), urine flow rate (V), renal plasma flow (RPF), and renin secretion rate.	Indomethacin	12-24	renin	Canis lupus familiaris	206-211
852103-1	1977	Infusion of indomethacin into anesthetized, salt-depleted dogs cuased an increase in mean arterial blood pressure (MABP), and decreases in heart rate (HR), urine flow rate (V), renal plasma flow (RPF), and renin secretion rate.	Salts	44-48	renin	Canis lupus familiaris	206-211
852103-5	1977	Renin secretion rate decreased from 1,194.1 +/- 353.9 U/min during control periods to reach 384.0 +/- 125.8 U/min (P less than 0.025) by 80 minutes of infusion of indomethacin.	Indomethacin	163-175	renin	Canis lupus familiaris	0-5
852103-6	1977	Subsequent infusion of prostaglandin E2 (PGE2) into the renal artery for 80 minutes caused increases of V to 0.53 +/- 0.13 ml/min (P less than 0.01), of RPF to 102.4 +/- 23.1 ml/min (P less than 0.01), and of renin secretion rate to 2,582.6 +/- 786.4 U/min (P less than 0.005).	Dinoprostone	23-39	renin	Canis lupus familiaris	209-214
852103-6	1977	Subsequent infusion of prostaglandin E2 (PGE2) into the renal artery for 80 minutes caused increases of V to 0.53 +/- 0.13 ml/min (P less than 0.01), of RPF to 102.4 +/- 23.1 ml/min (P less than 0.01), and of renin secretion rate to 2,582.6 +/- 786.4 U/min (P less than 0.005).	Dinoprostone	41-45	renin	Canis lupus familiaris	209-214
852103-7	1977	The decrease in renin secretion rate during the infusion of indomethacin persisted when renal perfusion pressure (RPP) was maintained relatively constant before and during the infusion of indomethacin.	Indomethacin	60-72	renin	Canis lupus familiaris	16-21
852103-7	1977	The decrease in renin secretion rate during the infusion of indomethacin persisted when renal perfusion pressure (RPP) was maintained relatively constant before and during the infusion of indomethacin.	Indomethacin	188-200	renin	Canis lupus familiaris	16-21
852103-9	1977	The data suggest that PGE1 and PGE2 play a role in the control of renin secretion.	Alprostadil	22-26	renin	Canis lupus familiaris	66-71
852103-9	1977	The data suggest that PGE1 and PGE2 play a role in the control of renin secretion.	Dinoprostone	31-35	renin	Canis lupus familiaris	66-71
323462-0	1977	Role of central and peripheral mechanisms in the action of alpha-methyldopa on blood pressure and renin secretion.	Methyldopa	59-75	renin	Canis lupus familiaris	98-103
323462-1	1977	The mechanism by which alpha-methyldopa lowers arterial pressure and suppresses renin secretion was investigated in pentobarbital-anesthetized dogs in which changes in renal perfusion pressure were prevented by adjusting a suprarenal aortic clamp.	Methyldopa	23-39	renin	Canis lupus familiaris	80-85
191299-4	1977	The centrally active alpha-adrenergic agonist clonidine decreases renin secretion, lowers blood pressure, inhibits ACTH and vasopressin secretion, and increases growth hormone secretion in dogs.	Clonidine	46-55	renin	Canis lupus familiaris	66-71
842668-7	1977	Thus, chronic sodium loading and DOCA administration causes renin depletion and dissociates the autoregulation of RBF and GFR.	Sodium	14-20	renin	Canis lupus familiaris	60-65
842668-7	1977	Thus, chronic sodium loading and DOCA administration causes renin depletion and dissociates the autoregulation of RBF and GFR.	Desoxycorticosterone Acetate	33-37	renin	Canis lupus familiaris	60-65
837470-0	1977	Intrarenal renin-angiotensin-sodium interdependent mechanism controlling postclamp renal artery pressure and renin release in the conscious dog with chronic one-kidney Goldblatt hypertension.	Sodium	29-35	renin	Canis lupus familiaris	11-16
837470-0	1977	Intrarenal renin-angiotensin-sodium interdependent mechanism controlling postclamp renal artery pressure and renin release in the conscious dog with chronic one-kidney Goldblatt hypertension.	Sodium	29-35	renin	Canis lupus familiaris	109-114
837470-2	1977	On normal sodium intake, intrarenal blockade of angiotensin II with Sar1-Ala8-angiotension II (P-113, saralasin acetate) markedly decreased postclamp renal artery pressure and increased renin release during the first 5 days after renal artery constriction.	Saralasin	102-119	renin	Canis lupus familiaris	186-191
206850-1	1978	To determine whether the inhibitory effect of clonidine (CLON) on renin secretion is due in part to a direct action on the kidneys or due entirely to an action on the brain, the drug was administered intravenously in a dose of 30 microgram/kg to dogs in which the spinal cord had been transected in the cervical region.	Clonidine	57-61	renin	Canis lupus familiaris	66-71
20199-2	1977	Intravenous injection of isoproterenol increases plasma renin activity (PRA) in anesthetized dogs.	Isoproterenol	25-38	renin	Canis lupus familiaris	56-61
830778-0	1977	Effect of calcium gluconate infusion on renin in the dog.	Calcium Gluconate	10-27	renin	Canis lupus familiaris	40-45
830778-1	1977	We have previously reported that infusion of CaCl2 into the renal artery of the dog inhibits renin release.	Calcium Chloride	45-50	renin	Canis lupus familiaris	93-98
830778-16	1977	Calcium gluconate had a lesser (p less than 0.01) inhibitory effect on renin than CaCl2, despite greater excretion of Ca++ and Na++ during calcium gluconate infusion.	Calcium Gluconate	0-17	renin	Canis lupus familiaris	71-76
830778-18	1977	The effect of Ca++ on renin may be mediated by NaCl transport across the macula densa.	Sodium Chloride	47-51	renin	Canis lupus familiaris	22-27
1000779-0	1976	Intrarenal site of action of calcium on renin secretion in dogs.	Calcium	29-36	renin	Canis lupus familiaris	40-45
17173-0	1977	[Comparative study of effect of 4 furochromone derivatives on isoprenaline induced plasma renin activity increase in anesthetized dogs.	furochromone	34-46	renin	Canis lupus familiaris	90-95
17173-0	1977	[Comparative study of effect of 4 furochromone derivatives on isoprenaline induced plasma renin activity increase in anesthetized dogs.	Isoproterenol	62-74	renin	Canis lupus familiaris	90-95
1000779-1	1976	We studied the effects of intrarenal calcium infusion on renin secretion in sodium-depleted dogs in an attempt to elucidate the major site of calcium-induced inhibition of renin release.	Calcium	37-44	renin	Canis lupus familiaris	57-62
1000779-1	1976	We studied the effects of intrarenal calcium infusion on renin secretion in sodium-depleted dogs in an attempt to elucidate the major site of calcium-induced inhibition of renin release.	Calcium	142-149	renin	Canis lupus familiaris	172-177
1071718-4	1976	PE-104 inhibited the rate of angiotensin formation from dog renin and renin substrate reaction.	PE 104	0-6	renin	Canis lupus familiaris	60-65
1000779-2	1976	Both calcium chloride and calcium gluconate reduced renal blood flow and renin secretion while renal perfusion pressure was unchanged.	Calcium Chloride	5-21	renin	Canis lupus familiaris	73-78
1071718-4	1976	PE-104 inhibited the rate of angiotensin formation from dog renin and renin substrate reaction.	PE 104	0-6	renin	Canis lupus familiaris	70-75
1000779-2	1976	Both calcium chloride and calcium gluconate reduced renal blood flow and renin secretion while renal perfusion pressure was unchanged.	Calcium Gluconate	26-43	renin	Canis lupus familiaris	73-78
1000779-3	1976	These data indicate that calcium inhibition of renin secretion did not occur primarily at the renal vascular receptor; decreased renal blood flow is usually associated with increased renin secretion.	Calcium	25-32	renin	Canis lupus familiaris	47-52
1000779-8	1976	The observation that calcium still suppressed renin release in these dogs provides additional evidence that the the major effect of calcium involved nontubular mechanisms.	Calcium	21-28	renin	Canis lupus familiaris	46-51
1000779-9	1976	Thus, it appears likely that calcium acted directly on the juxtaglomerular cells to inhibit renin secretion.	Calcium	29-36	renin	Canis lupus familiaris	92-97
1001347-0	1976	Natriuresis and renin release by the denervated dog kidney during furosemide administration.	Furosemide	66-76	renin	Canis lupus familiaris	16-21
1071584-0	1976	Effects of carotid occlusion and clonidine on renin secretion in anaesthetized dogs.	Clonidine	33-42	renin	Canis lupus familiaris	46-51
1071584-5	1976	Administration of clonidine decreased plasma renin activity, arterial pressure and heart rate and blocked the renin secretory and blood pressure responses to carotid occlusion.	Clonidine	18-27	renin	Canis lupus familiaris	45-50
1071584-5	1976	Administration of clonidine decreased plasma renin activity, arterial pressure and heart rate and blocked the renin secretory and blood pressure responses to carotid occlusion.	Clonidine	18-27	renin	Canis lupus familiaris	110-115
1071584-7	1976	These results support the hypothesis that the suppression of renin secretion by clonidine is a consequence of the decrease in sympathetic activity produced by this drug.	Clonidine	80-89	renin	Canis lupus familiaris	61-66
186247-2	1976	Infusion of 5 mug/kg X min glucagon produced a significant fall of plasma-renin, heart rate rose, but arterial mean pressure fell, and serum and urinary electrolytes did not change significantly, Cyclic AMP (dibutyryl-cAMP) significantly stimulated renin at a dose of 5 mg/min, while there were no significant changes in blood pressure, heart rate and serum and urinary electrolytes.	Glucagon	27-35	renin	Canis lupus familiaris	74-79
844139-7	1977	Plasma renin activity rose extremely rapidly as the level of aldosterone fell below normal and went to zero at aldosterone infusion rates slightly above normal.	Aldosterone	61-72	renin	Canis lupus familiaris	7-12
186247-2	1976	Infusion of 5 mug/kg X min glucagon produced a significant fall of plasma-renin, heart rate rose, but arterial mean pressure fell, and serum and urinary electrolytes did not change significantly, Cyclic AMP (dibutyryl-cAMP) significantly stimulated renin at a dose of 5 mg/min, while there were no significant changes in blood pressure, heart rate and serum and urinary electrolytes.	Glucagon	27-35	renin	Canis lupus familiaris	249-254
844250-4	1977	Frusemide, ethacrynic acid and bumetanide cause an immediate rise in renin secretion which is not inhibited either by DL-propranolol or by a bilateral ureterovenous anastomosis which prevents salt and water loss.	Furosemide	0-9	renin	Canis lupus familiaris	69-74
844250-4	1977	Frusemide, ethacrynic acid and bumetanide cause an immediate rise in renin secretion which is not inhibited either by DL-propranolol or by a bilateral ureterovenous anastomosis which prevents salt and water loss.	Ethacrynic Acid	11-26	renin	Canis lupus familiaris	69-74
844250-4	1977	Frusemide, ethacrynic acid and bumetanide cause an immediate rise in renin secretion which is not inhibited either by DL-propranolol or by a bilateral ureterovenous anastomosis which prevents salt and water loss.	Bumetanide	31-41	renin	Canis lupus familiaris	69-74
844250-4	1977	Frusemide, ethacrynic acid and bumetanide cause an immediate rise in renin secretion which is not inhibited either by DL-propranolol or by a bilateral ureterovenous anastomosis which prevents salt and water loss.	Salts	192-196	renin	Canis lupus familiaris	69-74
844250-12	1977	These results allow us to distinguish between a direct renal mechanism responsible for early renin hypersecretion, which appears to be connected with the action of the diuretic on the ascending limb of Henle"s loop, and an indirect mechanism responsible for late renin hypersecretion, which appears to be connected with salt and water loss.	Salts	320-324	renin	Canis lupus familiaris	93-98
1023189-2	1976	Intravenous injection of adrenalin (1--2 Mg/kg/min) caused an increase in the blood renin content and a reduction of the renal excretion of sodium, potassium and water.	Epinephrine	25-34	renin	Canis lupus familiaris	84-89
1023189-3	1976	Noradrenaline (1--2 Mg/kg/min) produced the contrary changes in the renin secretion and diuresis, this being associated with a different activity of catecholamines in respect to tha alpha- and beta-adrenoreceptors.	Norepinephrine	0-13	renin	Canis lupus familiaris	68-73
954826-0	1976	Effects of apomorphine and of pimozide on renin secretion in the anaesthetized dog.	Pimozide	30-38	renin	Canis lupus familiaris	42-47
954826-1	1976	This paper presents the results of a study of the receptors involved in renin hypersecretion induced by dopamine.	Dopamine	104-112	renin	Canis lupus familiaris	72-77
954826-2	1976	Apomorphine induces renin hypersecretion without significantly modifying the renal blood flow.	Apomorphine	0-11	renin	Canis lupus familiaris	20-25
954826-3	1976	This renin hypersecretion is inhibited by haloperidol.	Haloperidol	42-53	renin	Canis lupus familiaris	5-10
957249-6	1976	At a sodium deficit of 0-6 m-mole.kg-1 renin release had doubled.	Sodium	5-11	renin	Canis lupus familiaris	39-44
957249-10	1976	Precise replacement of sodium loss with isotonic saline but without replacement of other urinary components returned renin release to control levels.	Sodium	23-29	renin	Canis lupus familiaris	117-122
957249-10	1976	Precise replacement of sodium loss with isotonic saline but without replacement of other urinary components returned renin release to control levels.	Sodium Chloride	49-55	renin	Canis lupus familiaris	117-122
1265081-0	1976	Effect of intrarenal arterial infusion of magnesium on renin release in dogs.	Magnesium	42-51	renin	Canis lupus familiaris	55-60
1265081-4	1976	A significant stimulation of renin secretion occurred during magnesium administration.	Magnesium	61-70	renin	Canis lupus familiaris	29-34
988957-0	1976	Bumetanide induced increase of renal blood flow in conscious dogs and its relation to local renal hormones (PGE, kallikrein and renin).	Bumetanide	0-10	renin	Canis lupus familiaris	128-133
767286-2	1976	Moreover, in response to various provocative stimuli it can: (i) increase plasma renin activity in response to low sodium intake; (ii) suppress PRA in response to high sodium intake; (iii) produce increased serum erythropoietin in response to hypoxia.	Sodium	115-121	renin	Canis lupus familiaris	81-86
767286-2	1976	Moreover, in response to various provocative stimuli it can: (i) increase plasma renin activity in response to low sodium intake; (ii) suppress PRA in response to high sodium intake; (iii) produce increased serum erythropoietin in response to hypoxia.	Sodium	168-174	renin	Canis lupus familiaris	81-86
186247-0	1976	[The effects of calcitonin, glucagon and the dibutyryl derivative of cyclic AMP on plasma-renin activity (author"s transl)].	dibutyryl	45-54	renin	Canis lupus familiaris	90-95
186247-0	1976	[The effects of calcitonin, glucagon and the dibutyryl derivative of cyclic AMP on plasma-renin activity (author"s transl)].	Cyclic AMP	69-79	renin	Canis lupus familiaris	90-95
185095-2	1976	2) As sodium depletion progresses, the renin--angiotensin system becomes increasingly important in the maintenance of blood pressure.	Sodium	6-12	renin	Canis lupus familiaris	39-44
185095-6	1976	Although angiotensin II is essential for the initiation of the elevated blood pressure, the renin--angiotensin system plays a decreasing role in the maintenance of the chronic hypertension as sodium and water are retained, and plasma volume increases.	Sodium	192-198	renin	Canis lupus familiaris	92-97
185095-6	1976	Although angiotensin II is essential for the initiation of the elevated blood pressure, the renin--angiotensin system plays a decreasing role in the maintenance of the chronic hypertension as sodium and water are retained, and plasma volume increases.	Water	203-208	renin	Canis lupus familiaris	92-97
824442-6	1976	Indomethacin apparently affects furosemide-induced renin secretion at both the vascular and macula densa sites.	Indomethacin	0-12	renin	Canis lupus familiaris	51-56
824442-1	1976	The effects of furosemide on stimulation of renin secretion and urinary sodium excretion were studied in dogs pretreated with the prostaglandin synthetase inhibitors, indomethacin and meclofenamate.	Furosemide	15-25	renin	Canis lupus familiaris	44-49
824442-6	1976	Indomethacin apparently affects furosemide-induced renin secretion at both the vascular and macula densa sites.	Furosemide	32-42	renin	Canis lupus familiaris	51-56
984205-0	1976	Influence of dietary sodium on renin activity and arterial pressure during anesthesia.	Sodium	21-27	renin	Canis lupus familiaris	31-36
966372-6	1976	PE-72 and PE-104 inhibited the reaction between dog renin and substrate in a competitive way.	phosphorylethanolamine	0-2	renin	Canis lupus familiaris	52-57
966372-6	1976	PE-72 and PE-104 inhibited the reaction between dog renin and substrate in a competitive way.	phosphorylethanolamine	10-12	renin	Canis lupus familiaris	52-57
966375-4	1976	Intrarenal arterial infusion of acethylcholine abolished an autoregulation of blood flow and pressure reduction to 100mmHg during acetylcholine infusion resulted in a marked increase of renin secretion without any further change in afferent arteriolar resistance.	acethylcholine	32-46	renin	Canis lupus familiaris	186-191
966375-4	1976	Intrarenal arterial infusion of acethylcholine abolished an autoregulation of blood flow and pressure reduction to 100mmHg during acetylcholine infusion resulted in a marked increase of renin secretion without any further change in afferent arteriolar resistance.	Acetylcholine	130-143	renin	Canis lupus familiaris	186-191
966375-5	1976	Intrarenal arterial infusion of norepinephrine at a control pressure increased a renin release.	Norepinephrine	32-46	renin	Canis lupus familiaris	81-86
966375-6	1976	However, norepinephrine infusion at reduced pressure suppressed the renin release with recovery a vascular resistance to the control level.	Norepinephrine	9-23	renin	Canis lupus familiaris	68-73
181241-3	1976	Brain renin activity was partially purified by ammonium sulfate fractionation and Sephadex gel filtration, resulting in the removal of angiotensinase activity.	Ammonium Sulfate	47-63	renin	Canis lupus familiaris	6-11
181241-3	1976	Brain renin activity was partially purified by ammonium sulfate fractionation and Sephadex gel filtration, resulting in the removal of angiotensinase activity.	sephadex	82-90	renin	Canis lupus familiaris	6-11
935187-0	1976	Effects of propranolol on renin release during chronic thoracic caval constriction or acute renal artery stenosis in dogs.	Propranolol	11-22	renin	Canis lupus familiaris	26-31
975613-0	1976	Differing effects of the vasodilator drugs, prazosin and diazoxide on plasma renin activity in the dog.	Diazoxide	57-66	renin	Canis lupus familiaris	77-82
975613-7	1976	Prazosin lowered plasma renin activity to 62% (P less than 0-025) of the control value whereas diazoxide raised plasma renin activity to 178% (P less than 0.05) of the control value.	Prazosin	0-8	renin	Canis lupus familiaris	24-29
975613-7	1976	Prazosin lowered plasma renin activity to 62% (P less than 0-025) of the control value whereas diazoxide raised plasma renin activity to 178% (P less than 0.05) of the control value.	Diazoxide	95-104	renin	Canis lupus familiaris	119-124
975613-9	1976	The combination of vasodilatation and low renin activity observed following the administration of prazosin is unique, and may have clinical significance if these factors reduce the vascular complications of hypertension.	Prazosin	98-106	renin	Canis lupus familiaris	42-47
1083996-0	1976	[Influence of furosemide and propranolol (beta blocking agent) on plasmatic renin liberation in dogs].	Furosemide	14-24	renin	Canis lupus familiaris	76-81
987937-1	1976	UNLABELLED: The renin-angiotensin system, potassium and adrenocorticotropin (ACTH) are well known as control mechanism for aldosterone secretion.	Aldosterone	123-134	renin	Canis lupus familiaris	16-21
1259022-1	1976	Infusion of isoproterenol intravenously in normal dogs at rates of 0.10 or 0.018 mug/min per kg body wt increased renin secretion; at the lower infusion rate arterial pressure (AP) and renal blood flow (RBF) were unchanged.	Isoproterenol	12-25	renin	Canis lupus familiaris	114-119
1259022-2	1976	Isoproterenol was also infused into the renal artery in normal dogs at 0.10 mug/min per kg; renin secretion increased in association with an increase in RBF but AP was unchanged.	Isoproterenol	0-13	renin	Canis lupus familiaris	92-97
1259022-3	1976	Plasma K concentration was consistently decreased in all three of the above experiments and because hypokalemia is known to increase renin release isoproterenol was not infused intrarenally at the lower rate; the decrease in plasma K level precluded relating the entire response in renin release to isoproterenol.	Isoproterenol	147-160	renin	Canis lupus familiaris	133-138
1259022-4	1976	Intrarenal infusion of propranolol at 0.05 mg/kg per h in Na-depleted dogs decreased renin secretion whereas intravenous infusion at the same dose failed to alter renin release.	Propranolol	23-34	renin	Canis lupus familiaris	85-90
1083996-0	1976	[Influence of furosemide and propranolol (beta blocking agent) on plasmatic renin liberation in dogs].	Propranolol	29-40	renin	Canis lupus familiaris	76-81
1259022-5	1976	Intrarenal infusion of propranolol at this rate in Na-depleted dogs with a denervated, nonfiltering kidney also decreased renin release.	Propranolol	23-34	renin	Canis lupus familiaris	122-127
3519-1	1976	The ability of d,l-propranolol to block renin secretion in response to various extrarenal stimuli, such as hemorrhage and hypoglycemia, has been interpreted to indicate the presence of an intrarenal beta receptor regulating renin release.	Propranolol	15-30	renin	Canis lupus familiaris	40-45
3519-1	1976	The ability of d,l-propranolol to block renin secretion in response to various extrarenal stimuli, such as hemorrhage and hypoglycemia, has been interpreted to indicate the presence of an intrarenal beta receptor regulating renin release.	Propranolol	15-30	renin	Canis lupus familiaris	224-229
3519-4	1976	The effects of d,l-propranolol (anesthetic and beta-blocking activity), l-propranolol (beta-blocking activity only), and d-propranolol (local anesthetic activity only) on the renin response to RNS were examined.	Propranolol	121-134	renin	Canis lupus familiaris	175-180
3519-8	1976	A fourth group of dogs showed a rise in renin secretion from 205 to 880 U/min (P less than 0.001) in response to the first RNS, while the second RNS, given after an infusion of d-propranolol, caused a rise in renin secretion from 80 to 482 (P less than 0.005).	Propranolol	177-190	renin	Canis lupus familiaris	40-45
1255923-5	1976	Plasma renin activity was elevated in moderate respiratory acidosis induced by 5% carbon dioxide inhalation from 37.5 +/- 8.8 ng/ml to 52.8 +/- 7.0 ng/ml.	Carbon Dioxide	82-96	renin	Canis lupus familiaris	7-12
1255923-6	1976	In severe respiratory acidosis produced by 15% carbon dioxide inhalation, plasma renin activity elevated further to 85.8 +/- 8.6 ng/ml.	Carbon Dioxide	47-61	renin	Canis lupus familiaris	81-86
1255923-7	1976	Plasma renin activity of the hexamethonium bromide treated dogs was 19.0 +/- 3.5 ng/ml during room air breathing.	Hexamethonium	29-50	renin	Canis lupus familiaris	7-12
1255923-9	1976	These findings may suggest that the elevation of plasma renin activity in acute respiratory acidosis induced by carbon dioxide inhalation is independent from sympathetic stimulation.	Carbon Dioxide	112-126	renin	Canis lupus familiaris	56-61
200064-0	1976	Effect of adenosine compounds (ATP, cAMP) on renin release in vitro.	adenosine compounds	10-29	renin	Canis lupus familiaris	45-50
200064-0	1976	Effect of adenosine compounds (ATP, cAMP) on renin release in vitro.	Adenosine Triphosphate	31-34	renin	Canis lupus familiaris	45-50
200064-0	1976	Effect of adenosine compounds (ATP, cAMP) on renin release in vitro.	Cyclic AMP	36-40	renin	Canis lupus familiaris	45-50
200064-1	1976	Renin release by surviving canine renal cortical slices incubated media with ATP or cAMP at concentrations of 5 X 10(-5)--5 X 10(-3) M has been studied.	Adenosine Triphosphate	77-80	renin	Canis lupus familiaris	0-5
200064-1	1976	Renin release by surviving canine renal cortical slices incubated media with ATP or cAMP at concentrations of 5 X 10(-5)--5 X 10(-3) M has been studied.	Cyclic AMP	84-88	renin	Canis lupus familiaris	0-5
200064-2	1976	Both adenosine compounds were significantly increasing renin release.	Adenosine	5-14	renin	Canis lupus familiaris	55-60
139972-3	1976	This diuretic action was accompanied by the reduction of the renin hypersecretion elicited by water deprivation.	Water	94-99	renin	Canis lupus familiaris	61-66
59924-3	1976	The anti-renin globulins were coupled to cyanogen bromide activated Sepharose.	Cyanogen Bromide	41-57	renin	Canis lupus familiaris	9-14
59924-3	1976	The anti-renin globulins were coupled to cyanogen bromide activated Sepharose.	Sepharose	68-77	renin	Canis lupus familiaris	9-14
59924-4	1976	Using the anti-renin globulin-coupled Sepharose as an immuno-adsorbant, a method was devised allowing purification of plasma renin to a 1,000-fold purity.	Sepharose	38-47	renin	Canis lupus familiaris	15-20
59924-4	1976	Using the anti-renin globulin-coupled Sepharose as an immuno-adsorbant, a method was devised allowing purification of plasma renin to a 1,000-fold purity.	Sepharose	38-47	renin	Canis lupus familiaris	125-130
1215977-1	1975	In dogs, plasma renin activity (PRA) was increased by anesthesia, by hypercapnia and by extreme hypoxia (paO2 47.6 mm Hg).	pao2	105-109	renin	Canis lupus familiaris	16-21
1192558-7	1975	The impaired renal perfusion and abnormal elevation of plasma renin activity during salt restriction is analogous to clinical and experimental observations in hypertensive states associated with total renal underperfusion and supports a major role for the renal pressor system in the pathogenesis of coarctation hypertension.	Salts	84-88	renin	Canis lupus familiaris	62-67
1208233-0	1975	The activation of the renin--angiotensin system in the dog after injection of noradrenaline into the lateral brain ventricle.	Norepinephrine	78-91	renin	Canis lupus familiaris	22-27
1208233-7	1975	The increase in the concentration of endogenous NA in the brain by desmethylimipramine and RO 4-1284 also caused an activation of renin--angiotensin system.	2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-	91-100	renin	Canis lupus familiaris	130-135
1238024-0	1975	Plasma renin activity during pentobarbital anesthesia and graded hemorrhage in dogs.	Pentobarbital	29-42	renin	Canis lupus familiaris	7-12
1182938-2	1975	Experiments were undertaken to investigate further the effect of furosemide on renin secretion in the anesthetized dog.	Furosemide	65-75	renin	Canis lupus familiaris	79-84
1248068-3	1976	The reduction in blood flow was prevented by a high salt intake and partially reversed by agents which interrupt the renin-angiotensin system (BPF 9a; 1-Sar,8-Ala-angiotensin II; propranolol) but not by alpha-adrenergic blocking agents (phentolamine and phenoxybenzamine).	1-sar	151-156	renin	Canis lupus familiaris	117-122
1248068-3	1976	The reduction in blood flow was prevented by a high salt intake and partially reversed by agents which interrupt the renin-angiotensin system (BPF 9a; 1-Sar,8-Ala-angiotensin II; propranolol) but not by alpha-adrenergic blocking agents (phentolamine and phenoxybenzamine).	Propranolol	179-190	renin	Canis lupus familiaris	117-122
1195507-2	1975	Plasma renin activity, measured by radioimmunoassay, was enhanced (P less than 0.001) during inhalation of CO2 despite insignificant changes in renal blood flow and arterial pressure.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	107-110	renin	Canis lupus familiaris	7-12
1211457-5	1975	The elevation in renin secretion rate decreased between 30 and 122 min after the initiation of RAO in the pentobarbital-anesthetized dogs but not in the chloralose-urethan-anesthetized dogs.	Pentobarbital	106-119	renin	Canis lupus familiaris	17-22
1211457-5	1975	The elevation in renin secretion rate decreased between 30 and 122 min after the initiation of RAO in the pentobarbital-anesthetized dogs but not in the chloralose-urethan-anesthetized dogs.	Urethane	164-171	renin	Canis lupus familiaris	17-22
1211457-6	1975	These experiments indicate that during RAO release of renin causes, through formation of angiotensin, an increase in RVR in the contralateral kidney and intra-arterial administration of P-113 restores the vascular resistance to a near-normal level.	Saralasin	186-191	renin	Canis lupus familiaris	54-59
1175505-5	1975	When the renin was preceded by intraventricular saralasin acetate, a specific antagonist of angiotensin II, the drinking response was reduced to 8 +/- 6 ml.	Acetates	58-65	renin	Canis lupus familiaris	9-14
1175505-6	1975	In eight pentobarbital anesthetized dogs, intraventricular dog or hog renin (0.05-0.25 Goldblatt units) increased systolic pressure from 152 +/- 10 to 168 +/- 10 mm Hg (P less than 0.001) and diastolic pressure from 101 +/- 8 to 116 +/- 7 mm Hg (P less than 0.001).	Pentobarbital	9-22	renin	Canis lupus familiaris	70-75
1213205-1	1975	In acute experiments on dogs, a negative correlation between arterial pressure and the blood renin activity was shown during hemodynamic shifts following occlusion of the carotid arteries or v. cava anterior, as well as ephedrinum or nitrite of sodium administration.	Nitrites	234-241	renin	Canis lupus familiaris	93-98
1213205-1	1975	In acute experiments on dogs, a negative correlation between arterial pressure and the blood renin activity was shown during hemodynamic shifts following occlusion of the carotid arteries or v. cava anterior, as well as ephedrinum or nitrite of sodium administration.	Sodium	245-251	renin	Canis lupus familiaris	93-98
1177375-0	1975	Influence of ethacrynic acid on intrarenal renin release mechanisms.	Ethacrynic Acid	13-28	renin	Canis lupus familiaris	43-48
1177375-6	1975	Infusion of hypertonic saline during autoregulated vasodilatation induced by arterial constriction had a similar effect, but again renin release continued to exceed control.	Sodium Chloride	23-29	renin	Canis lupus familiaris	131-136
1177375-7	1975	We propose that ethacrynic acid increases renin release through a hemodynamic mechanism triggered by afferent arteriolar dilation and inhibits renin release by greatly increasing the delivery of sodium to the distal convoluted tubules.	Ethacrynic Acid	16-31	renin	Canis lupus familiaris	42-47
1177375-7	1975	We propose that ethacrynic acid increases renin release through a hemodynamic mechanism triggered by afferent arteriolar dilation and inhibits renin release by greatly increasing the delivery of sodium to the distal convoluted tubules.	Ethacrynic Acid	16-31	renin	Canis lupus familiaris	143-148
1177375-7	1975	We propose that ethacrynic acid increases renin release through a hemodynamic mechanism triggered by afferent arteriolar dilation and inhibits renin release by greatly increasing the delivery of sodium to the distal convoluted tubules.	Sodium	195-201	renin	Canis lupus familiaris	42-47
1163662-0	1975	Effect of KCl infusion on renin secretory rates and aldosterone excretion in dogs.	Potassium Chloride	10-13	renin	Canis lupus familiaris	26-31
1175682-0	1975	Effect of dopamine on renin secretion in the anesthetized dog.	Dopamine	10-18	renin	Canis lupus familiaris	22-27
1175682-1	1975	Intrarenal perfusion of dopamine (6 mug/kg/min for 10 min) caused a significant increase of renin secretion, together with a significant increase in renal blood flow.	Dopamine	24-32	renin	Canis lupus familiaris	92-97
1175682-3	1975	The role of intrarenal dopaminergic receptors has been studied: (a) Haloperidol (intrarenal perfusion of 50 mug/kg/min for 20 min) suppresses the renal vasodilation and renin hypersecretion induced by dopamine.	Haloperidol	68-79	renin	Canis lupus familiaris	169-174
1149185-6	1975	Infusion of des-1-Asp-angiotensin II into sodium-depleted dogs decreased renin secretion from 1094 +/- 211 ng/min to 768 +/- 132 and 499 +/- 31 ng/min (P less than 0.025 for both values) after 10 and 30 minutes of infusion.	Sodium	42-48	renin	Canis lupus familiaris	73-78
805674-0	1975	Influence of the renin-angiotensin system on the effect of prostaglandin synthesis inhibitors in the renal vasculature.	Prostaglandins	59-72	renin	Canis lupus familiaris	17-22
805674-9	1975	The results of these experiments indicated that renal prostaglandins have more influence on renal blood flow during renal ischemia than under basal conditions, and that the renin-angiotensin system may be involved in activating synthesis and release of prostaglandins during ischemia.	Prostaglandins	253-267	renin	Canis lupus familiaris	173-178
238860-3	1975	When plasma renin activity was suppressed in diuretic-treated dogs by the potent beta-adrenergic receptor-blocking drug, timolol (0.5, 2 mg/kg/day p.o.	Timolol	121-128	renin	Canis lupus familiaris	12-17
1077761-2	1975	The effect of propranolol and sotalol on renin secretion was studied in the anaesthetized dog.	Sotalol	30-37	renin	Canis lupus familiaris	41-46
1149327-0	1975	Abolition of the renin-releasing action of frusemide by acute renal denervation in dogs.	Furosemide	43-52	renin	Canis lupus familiaris	17-22
1149327-2	1975	The effects of infusions of frusemide at low (0.05-0.1 mg.kg-1.min-1) and high (0.5-2.0 mg.kg-1.min-1) rates were studied on renin secretion and urinary outputs of sodium and potassium in anaesthetized dogs in which one kidney was removed and the remaining kidney was either innervated or denervated.	Furosemide	28-37	renin	Canis lupus familiaris	125-130
1149327-5	1975	Without replacement of urinary losses, renin secretion increased at sodium deficits of 0.7-0.9 mmol.kg-1 in the presence of elevated rates of sodium and potassium excretion.	Sodium	68-74	renin	Canis lupus familiaris	39-44
1149327-7	1975	High rates of infusion of frusemide caused an immediate increase in renin secretion from innervated kidneys which was not related to urinary losses.	Furosemide	26-35	renin	Canis lupus familiaris	68-73
1149327-11	1975	Denervation of the kidney abolished the renin-releasing action of frusemide at both low and high infusion rates even when the sodium deficit amounted to 4.3 mmol.kg-1.	Furosemide	66-75	renin	Canis lupus familiaris	40-45
1149327-13	1975	Constriction of the aorta producing a fall of 10-30 mmHg in perfusion pressure raised the rate of renin secretion from denervated kidneys to control levels and partially restored the renin-releasing action of frusemide at high infusion rates.	Furosemide	209-218	renin	Canis lupus familiaris	98-103
1149327-13	1975	Constriction of the aorta producing a fall of 10-30 mmHg in perfusion pressure raised the rate of renin secretion from denervated kidneys to control levels and partially restored the renin-releasing action of frusemide at high infusion rates.	Furosemide	209-218	renin	Canis lupus familiaris	183-188
1149327-15	1975	The findings indicate that frusemide has a site of action apart from the macula densa in mediating renin release.	Furosemide	27-36	renin	Canis lupus familiaris	99-104
1182938-4	1975	Furosemide, in a dose of 5 mg/kg, increased renin secretion and decreased renal resistance in dogs with a nonfiltering kidney.	Furosemide	0-10	renin	Canis lupus familiaris	44-49
1182938-5	1975	Prior dilation of the nonfiltering kidney with either acetylcholine or papaverine prevented changes in both resistance and renin secretion.	Acetylcholine	54-67	renin	Canis lupus familiaris	123-128
1182938-5	1975	Prior dilation of the nonfiltering kidney with either acetylcholine or papaverine prevented changes in both resistance and renin secretion.	Papaverine	71-81	renin	Canis lupus familiaris	123-128
1182938-6	1975	However, following dilation of the intact filtering kidney with acetylcholine, furosemide caused an increase in renin secretion.	Furosemide	79-89	renin	Canis lupus familiaris	112-117
1182938-7	1975	Infusion of d,l-propranolol decreased renin secretion in both the filtering and the nonfiltering kidneys.	Propranolol	12-27	renin	Canis lupus familiaris	38-43
1182938-8	1975	Following propranolol treatment, furosemide increased renin secretion in the filtering kidney but had no effect on renal resistance.	Propranolol	10-21	renin	Canis lupus familiaris	54-59
1182938-8	1975	Following propranolol treatment, furosemide increased renin secretion in the filtering kidney but had no effect on renal resistance.	Furosemide	33-43	renin	Canis lupus familiaris	54-59
1182938-9	1975	These experiments indicate that furosemide stimulates renin secretion by both the macula densa and the baroreceptor mechanisms.	Furosemide	32-42	renin	Canis lupus familiaris	54-59
1115240-7	1975	In additional experiments in which the plasma renin level was measured, the potentiation of responses to sympathetic stimulation and a high dose of norepinephrine (2 mug) occurred at the time that the renin level was increased by hemorrhage.	Norepinephrine	148-162	renin	Canis lupus familiaris	46-51
1115240-7	1975	In additional experiments in which the plasma renin level was measured, the potentiation of responses to sympathetic stimulation and a high dose of norepinephrine (2 mug) occurred at the time that the renin level was increased by hemorrhage.	Norepinephrine	148-162	renin	Canis lupus familiaris	201-206
5084885-0	1972	Effects of renal arterial infusion of sodium and potassium on renin secretion in the dog.	Sodium	38-44	renin	Canis lupus familiaris	62-67
1129331-6	1975	Stimulation of renin secretion occurred after furosemide in indomethacin-treated animals.	Furosemide	46-56	renin	Canis lupus familiaris	15-20
1129331-6	1975	Stimulation of renin secretion occurred after furosemide in indomethacin-treated animals.	Indomethacin	60-72	renin	Canis lupus familiaris	15-20
163152-0	1975	Catecholamine-dependent cyclic adenosine monophosphate and renin in the dog kidney.	Catecholamines	0-13	renin	Canis lupus familiaris	59-64
163152-2	1975	Therefore, the possible role of catecholamine-dependent cyclic AMP in the release of renin was investigated in lithium-treated dogs both in vivo and vitro.	Catecholamines	32-45	renin	Canis lupus familiaris	85-90
163152-2	1975	Therefore, the possible role of catecholamine-dependent cyclic AMP in the release of renin was investigated in lithium-treated dogs both in vivo and vitro.	Cyclic AMP	56-66	renin	Canis lupus familiaris	85-90
163152-2	1975	Therefore, the possible role of catecholamine-dependent cyclic AMP in the release of renin was investigated in lithium-treated dogs both in vivo and vitro.	Lithium	111-118	renin	Canis lupus familiaris	85-90
163152-5	1975	The finding that, in the lithium-treated dogs, isoproternol increased plasma renin activity but not cyclic AMP generation in the kidney suggests that the increase in plasma renin activity observed after an injection of isoproterenol is probably not mediated through the beta-adrenergic stimulus-dependent cyclic AMP system in the kidney.	Lithium	25-32	renin	Canis lupus familiaris	77-82
163152-5	1975	The finding that, in the lithium-treated dogs, isoproternol increased plasma renin activity but not cyclic AMP generation in the kidney suggests that the increase in plasma renin activity observed after an injection of isoproterenol is probably not mediated through the beta-adrenergic stimulus-dependent cyclic AMP system in the kidney.	Lithium	25-32	renin	Canis lupus familiaris	173-178
163152-5	1975	The finding that, in the lithium-treated dogs, isoproternol increased plasma renin activity but not cyclic AMP generation in the kidney suggests that the increase in plasma renin activity observed after an injection of isoproterenol is probably not mediated through the beta-adrenergic stimulus-dependent cyclic AMP system in the kidney.	isoproternol	47-59	renin	Canis lupus familiaris	77-82
163152-5	1975	The finding that, in the lithium-treated dogs, isoproternol increased plasma renin activity but not cyclic AMP generation in the kidney suggests that the increase in plasma renin activity observed after an injection of isoproterenol is probably not mediated through the beta-adrenergic stimulus-dependent cyclic AMP system in the kidney.	Isoproterenol	219-232	renin	Canis lupus familiaris	173-178
1120965-0	1975	Studies concerning the mechanism of suppression of renin secretion by clonidine.	Clonidine	70-79	renin	Canis lupus familiaris	51-56
1120965-1	1975	Two series of experiments were performed in anesthetized dogs to test the hypothesis that the suppression of renin secretion by clonidine results from a centrally mediated decrease in the activity in the renal sympathetic nerves.	Clonidine	128-137	renin	Canis lupus familiaris	109-114
1120965-3	1975	In these animals, clonidine produced hypotension and bradycardia and suppressed plasma renin activity to 39 percent of the control value.	Clonidine	18-27	renin	Canis lupus familiaris	87-92
1120965-7	1975	Intravenous clonidine produced a transient hypertension followed by hypotension, decreased heart rate and suppressed plasma renin activity to 49 percent of the control value.	Clonidine	12-21	renin	Canis lupus familiaris	124-129
1120965-8	1975	Renal denervation reduced renin secretion and prevented the suppression of renin secretion produced by intravenous clonidine.	Clonidine	115-124	renin	Canis lupus familiaris	75-80
1120965-9	1975	Thus, these data are consistent with the hypothesis that the suppression of renin secretion by clonidine results from a centrally mediated decrease in renal sympathetic neural tone.	Clonidine	95-104	renin	Canis lupus familiaris	76-81
1129293-3	1975	RV-A renin increased during stop flow from its average value during clearance periods, whether 10% mannitol in 0.15 M NaCl or 10% mannitol in 0.1 M Na2SO4 was being administered intravenously.	Mannitol	99-107	renin	Canis lupus familiaris	5-10
1129293-3	1975	RV-A renin increased during stop flow from its average value during clearance periods, whether 10% mannitol in 0.15 M NaCl or 10% mannitol in 0.1 M Na2SO4 was being administered intravenously.	Sodium Chloride	118-122	renin	Canis lupus familiaris	5-10
1129293-3	1975	RV-A renin increased during stop flow from its average value during clearance periods, whether 10% mannitol in 0.15 M NaCl or 10% mannitol in 0.1 M Na2SO4 was being administered intravenously.	Mannitol	130-138	renin	Canis lupus familiaris	5-10
1129293-3	1975	RV-A renin increased during stop flow from its average value during clearance periods, whether 10% mannitol in 0.15 M NaCl or 10% mannitol in 0.1 M Na2SO4 was being administered intravenously.	sodium sulfate	148-154	renin	Canis lupus familiaris	5-10
1129293-4	1975	However, RV-A renin during mannitol + NaCl stop-flow periods was significantly greater than during mannitol + Na2SO4 stop-flow periods.	Mannitol	27-35	renin	Canis lupus familiaris	14-19
1129293-4	1975	However, RV-A renin during mannitol + NaCl stop-flow periods was significantly greater than during mannitol + Na2SO4 stop-flow periods.	Sodium Chloride	38-42	renin	Canis lupus familiaris	14-19
234821-6	1975	Plasma renin activity, which did not change during treatment with timolol, was substantially elevated during treatment with hydrochlorothiazide.	Hydrochlorothiazide	124-143	renin	Canis lupus familiaris	7-12
234821-8	1975	When timolol was administered concomitantly with hydrochlorothiazide, plasma renin activity was suppressed and blood pressure was significantly lowered.	Timolol	5-12	renin	Canis lupus familiaris	77-82
234821-8	1975	When timolol was administered concomitantly with hydrochlorothiazide, plasma renin activity was suppressed and blood pressure was significantly lowered.	Hydrochlorothiazide	49-68	renin	Canis lupus familiaris	77-82
234821-10	1975	These observations suggest that compensatory activation of the renin-angiotensin system limits the antihypertensive activity of hydrochlorothiazide in renal hypertensive dogs and suppression of diuretic-induced renin release by timolol unmasks the antihypertensive effect of the diuretic.	Hydrochlorothiazide	128-147	renin	Canis lupus familiaris	63-68
234821-10	1975	These observations suggest that compensatory activation of the renin-angiotensin system limits the antihypertensive activity of hydrochlorothiazide in renal hypertensive dogs and suppression of diuretic-induced renin release by timolol unmasks the antihypertensive effect of the diuretic.	Timolol	228-235	renin	Canis lupus familiaris	63-68
234821-10	1975	These observations suggest that compensatory activation of the renin-angiotensin system limits the antihypertensive activity of hydrochlorothiazide in renal hypertensive dogs and suppression of diuretic-induced renin release by timolol unmasks the antihypertensive effect of the diuretic.	Timolol	228-235	renin	Canis lupus familiaris	211-216
192043-4	1975	Decreased renin secretion was explained by the Na-load on the macula densa segment, being decreased by the intrarenal shifting of renal blood flow and with an eventual decomposition of cAMP.	Cyclic AMP	185-189	renin	Canis lupus familiaris	10-15
1183077-0	1975	Influence of plasma and extracellular fluid volumes on plasma renin activity in sodium-depleted dogs.	Sodium	80-86	renin	Canis lupus familiaris	62-67
1112661-6	1975	Both prostaglandins increased the renal vein renin in the infused kidney.	Prostaglandins	5-19	renin	Canis lupus familiaris	45-50
1112661-7	1975	PGA-1 did affect renin release of the noninfused kidney, but PGE-1, which is rapidly inactivated by the lung, did not have this effect.	prostaglandin A1	0-5	renin	Canis lupus familiaris	17-22
1112661-10	1975	The increased renin release after prostaglandin administration seems to be a protective renal mechanism against the drug-induced hypotension.	Prostaglandins	34-47	renin	Canis lupus familiaris	14-19
1096294-0	1975	Effect of circulating norepinephrine on the renin release from the denervated kidney.	Norepinephrine	22-36	renin	Canis lupus familiaris	44-49
1096294-1	1975	The effect of renal denervation on the reactivity of the renin release mechanism to circulating norepinephrine was studied in six dogs with renal autografts.	Norepinephrine	96-110	renin	Canis lupus familiaris	57-62
1096294-3	1975	Both kidneys showed an increased release of renin when norepinephrine was given.	Norepinephrine	55-69	renin	Canis lupus familiaris	44-49
1096294-5	1975	Propranolol blocked the release of renin induced by norepinephrine without affecting either the reduced blood flow thorugh the autograft or the elevated blood pressure.	Propranolol	0-11	renin	Canis lupus familiaris	35-40
1096294-5	1975	Propranolol blocked the release of renin induced by norepinephrine without affecting either the reduced blood flow thorugh the autograft or the elevated blood pressure.	Norepinephrine	52-66	renin	Canis lupus familiaris	35-40
1096294-7	1975	The findings indicate that the renin release induced by circulating norepinephrine is independent of the intrarenal adrenergic nerves, and rather suggest that it is the result of an action of norepinephrine directly on the renin-producing juxtaglomerular cells.	Norepinephrine	68-82	renin	Canis lupus familiaris	31-36
1096294-7	1975	The findings indicate that the renin release induced by circulating norepinephrine is independent of the intrarenal adrenergic nerves, and rather suggest that it is the result of an action of norepinephrine directly on the renin-producing juxtaglomerular cells.	Norepinephrine	192-206	renin	Canis lupus familiaris	31-36
1096294-7	1975	The findings indicate that the renin release induced by circulating norepinephrine is independent of the intrarenal adrenergic nerves, and rather suggest that it is the result of an action of norepinephrine directly on the renin-producing juxtaglomerular cells.	Norepinephrine	192-206	renin	Canis lupus familiaris	223-228
4156186-0	1974	[Action of 3 beta adrenolytics on plasma renin hyperactivity induced by isoprenaline in the anesthtized dog.	Isoproterenol	72-84	renin	Canis lupus familiaris	41-46
1248451-3	1976	Intraventricular injection of hog renin in a dose of 0.1 Goldblatt unit produced a marked decrease in urine flow which was associated with a decrease in free water clearance and an increase in urinary osmolatiy with no change in osmolar clearance.	Water	158-163	renin	Canis lupus familiaris	34-39
1248451-7	1976	Intraventricular administration of saralasin acetate, a specific antagonist of angiotensin II, completely blocked the effects of intraventricular renin indicating that these effects were mediated via the formation of angiotensin II.	Saralasin	35-52	renin	Canis lupus familiaris	146-151
4851601-0	1974	Effect of adrenoceptor-blocking agents on the renin response to isoproterenol in dogs.	Isoproterenol	64-77	renin	Canis lupus familiaris	46-51
4859545-0	1974	The nature of renin released in the dog followin haemorrhage and frusemide.	Furosemide	65-74	renin	Canis lupus familiaris	14-19
4708961-0	1973	Renin output by diseased and contralateral normal dog kidneys following extracellular fluid volume expansion and furosemide.	Furosemide	113-123	renin	Canis lupus familiaris	0-5
4659318-0	1972	Effects of hemorrhage and furosemide on renin release in dogs.	Furosemide	26-36	renin	Canis lupus familiaris	40-45
5084885-0	1972	Effects of renal arterial infusion of sodium and potassium on renin secretion in the dog.	Potassium	49-58	renin	Canis lupus familiaris	62-67
4402350-1	1972	The present study was undertaken to examine whether the beta adrenergic agonist, isoproterenol, increases plasma renin activity (PRA) by activation of intrarenal or extrarenal pathways.	Isoproterenol	81-94	renin	Canis lupus familiaris	113-118
4402350-18	1972	These results do not provide evidence for a role of intrarenal beta adrenergic receptors in the control of renin release and indicate that the effect of beta adrenergic stimulation with isoproterenol to increase the release of renin is mediated by an extrarenal mechanism.	Isoproterenol	186-199	renin	Canis lupus familiaris	227-232
4402350-20	1972	isoproterenol occurred in the absence of changes in plasma potassium concentration, renal perfusion pressure, glomerular filtration rate, renal plasma flow, and electrolyte excretion and was not abolished by renal denervation, the possibility must be considered that the effect on renin secretion is mediated by circulatory factors.	Isoproterenol	0-13	renin	Canis lupus familiaris	281-286
4401810-0	1972	Stimulation of renin secretion in dogs by theophylline.	Theophylline	42-54	renin	Canis lupus familiaris	15-20
5033118-0	1972	Effects of dopamine and isoproterenol on renin secretion in the dog.	Dopamine	11-19	renin	Canis lupus familiaris	41-46
5033118-0	1972	Effects of dopamine and isoproterenol on renin secretion in the dog.	Isoproterenol	24-37	renin	Canis lupus familiaris	41-46
4378027-1	1972	Phentolamine-induced blockade of alpha-adrenoreceptors and subsequent beta-adrenoreceptor stimulation by intravenous injection of adrenaline or phenylephrine (Mezaton) in anaesthtized dogs was accompanied by an elevation of plasma renin activitiy in peripheral blood and a reduction of renal excretion of sodium, potassium, and water.	Phentolamine	0-12	renin	Canis lupus familiaris	231-236
4378027-1	1972	Phentolamine-induced blockade of alpha-adrenoreceptors and subsequent beta-adrenoreceptor stimulation by intravenous injection of adrenaline or phenylephrine (Mezaton) in anaesthtized dogs was accompanied by an elevation of plasma renin activitiy in peripheral blood and a reduction of renal excretion of sodium, potassium, and water.	Phenylephrine	144-157	renin	Canis lupus familiaris	231-236
5064563-0	1972	[Effect of clopamide and ethacrynic acid on renin secretion in the dog].	Clopamide	11-20	renin	Canis lupus familiaris	44-49
5064563-0	1972	[Effect of clopamide and ethacrynic acid on renin secretion in the dog].	Ethacrynic Acid	25-40	renin	Canis lupus familiaris	44-49
4378027-1	1972	Phentolamine-induced blockade of alpha-adrenoreceptors and subsequent beta-adrenoreceptor stimulation by intravenous injection of adrenaline or phenylephrine (Mezaton) in anaesthtized dogs was accompanied by an elevation of plasma renin activitiy in peripheral blood and a reduction of renal excretion of sodium, potassium, and water.	Phenylephrine	159-166	renin	Canis lupus familiaris	231-236
4378027-1	1972	Phentolamine-induced blockade of alpha-adrenoreceptors and subsequent beta-adrenoreceptor stimulation by intravenous injection of adrenaline or phenylephrine (Mezaton) in anaesthtized dogs was accompanied by an elevation of plasma renin activitiy in peripheral blood and a reduction of renal excretion of sodium, potassium, and water.	Sodium	305-311	renin	Canis lupus familiaris	231-236
4378027-1	1972	Phentolamine-induced blockade of alpha-adrenoreceptors and subsequent beta-adrenoreceptor stimulation by intravenous injection of adrenaline or phenylephrine (Mezaton) in anaesthtized dogs was accompanied by an elevation of plasma renin activitiy in peripheral blood and a reduction of renal excretion of sodium, potassium, and water.	Potassium	313-322	renin	Canis lupus familiaris	231-236
4378027-1	1972	Phentolamine-induced blockade of alpha-adrenoreceptors and subsequent beta-adrenoreceptor stimulation by intravenous injection of adrenaline or phenylephrine (Mezaton) in anaesthtized dogs was accompanied by an elevation of plasma renin activitiy in peripheral blood and a reduction of renal excretion of sodium, potassium, and water.	Water	328-333	renin	Canis lupus familiaris	231-236
4308808-0	1969	Mechanism of the effects of furosemide on renin secretion in anesthetized dogs.	Furosemide	28-38	renin	Canis lupus familiaris	42-47
5124305-0	1971	Effect of metyrapone on plasma renin activity in dogs.	Metyrapone	10-20	renin	Canis lupus familiaris	31-36
4394849-0	1970	The effect of alpha- and beta-adrenergic blocking agents on the renin response to hypoglycemia and epinephrine in dogs.	Epinephrine	99-110	renin	Canis lupus familiaris	64-69
5431662-0	1970	Effects of chronic potassium deficiency on plasma renin activity.	Potassium	19-28	renin	Canis lupus familiaris	50-55
5431662-7	1970	However, in every case increased renin activity persisted throughout depletion despite development of sodium retention sufficient to inhibit renin release in normal dogs.	Sodium	102-108	renin	Canis lupus familiaris	141-146
5431662-8	1970	Potassium repletion resulted in a prompt decrease in renin activity to predepletion values.	Potassium	0-9	renin	Canis lupus familiaris	53-58
5431662-9	1970	This study indicates that potassium deficiency has a stimulatory effect on renin release that is independent of any effect on sodium balance.	Potassium	26-35	renin	Canis lupus familiaris	75-80
4316111-0	1970	The effect of immunity to renin on the renal response to saline infusions in dogs.	Sodium Chloride	57-63	renin	Canis lupus familiaris	26-31
4313452-0	1970	Effects of adenosine compounds on renal function and renin secretion in dogs.	Adenosine	11-20	renin	Canis lupus familiaris	53-58
5360986-0	1969	Effect of acetylcholine on renin secretion in salt-depleted dogs.	Acetylcholine	10-23	renin	Canis lupus familiaris	27-32
5775884-0	1969	Effects of deoxycorticosterone on plasma renin acitivity in conscious dogs.	Desoxycorticosterone	11-30	renin	Canis lupus familiaris	41-46
4293657-0	1967	Chemical assay of phospholipid renin preinhibitor in canine and human blood.	Phospholipids	18-30	renin	Canis lupus familiaris	31-36
4976775-0	1969	[Action of furosemide on renin secretion in dogs].	Furosemide	11-21	renin	Canis lupus familiaris	25-30
5688014-0	1968	Inhibition of renin release in the dog by vasopressin and vasotocin.	Vasotocin	58-67	renin	Canis lupus familiaris	14-19
4305249-2	1968	Relationship between renin secretion and plasma sodium concentration in the peritoneal dialyzed dog.	Sodium	48-54	renin	Canis lupus familiaris	21-26
13627212-0	1959	Pressor effect of subcutaneous renin in dogs, and effect of reserpine, 1-hydrazinophthalazine and hexamethonium on renin hypertension.	Hexamethonium	98-111	renin	Canis lupus familiaris	115-120
6020540-0	1967	Effects of mercurial diuresis and acute sodium depletion on renin release in dog.	Sodium	40-46	renin	Canis lupus familiaris	60-65
4285012-0	1965	Effects of infusion of catecholamines and angiotensin II on renin release in anesthetized dogs.	Catecholamines	23-37	renin	Canis lupus familiaris	60-65
17772081-1	1963	Infusion of angiotensin or renin in small quantities affects the sympathetic nervous system so that responses are increased to either drugs or reflexes that cause release of norepinephrine at nerve endings.	Norepinephrine	174-188	renin	Canis lupus familiaris	27-32
19871025-10	1940	Since renin is liberated into the renal vein in large amounts in hypertensive dogs and reacts with renin-activator to produce angiotonin and since the conditions of the experiment are such as to enhance greatly the sensitivity of the ear preparation to angiotonin, it is believed that the vasoconstriction is the result of the presence of angiotonin in the peripheral blood.	Angiotensin Amide	126-136	renin	Canis lupus familiaris	6-11
13030747-0	1953	Effects of ACTH, cortisone, desoxycorticosterone and epinephrine on the plasma hypertensinogen and renin concentration of dogs.	Epinephrine	53-64	renin	Canis lupus familiaris	99-104
19871310-3	1943	Extraction of finely ground fresh hog kidney with distilled water adjusted to pH 7.8 with sodium hydroxide, followed by successive treatment, as described, with trichloroacetic acid and acetone, gives renin in good yield of a purity suitable for physiological studies and a good starting material for further purification.	Trichloroacetic Acid	161-181	renin	Canis lupus familiaris	201-206
19871310-3	1943	Extraction of finely ground fresh hog kidney with distilled water adjusted to pH 7.8 with sodium hydroxide, followed by successive treatment, as described, with trichloroacetic acid and acetone, gives renin in good yield of a purity suitable for physiological studies and a good starting material for further purification.	Acetone	186-193	renin	Canis lupus familiaris	201-206
19871025-10	1940	Since renin is liberated into the renal vein in large amounts in hypertensive dogs and reacts with renin-activator to produce angiotonin and since the conditions of the experiment are such as to enhance greatly the sensitivity of the ear preparation to angiotonin, it is believed that the vasoconstriction is the result of the presence of angiotonin in the peripheral blood.	Angiotensin Amide	126-136	renin	Canis lupus familiaris	99-104
19871025-10	1940	Since renin is liberated into the renal vein in large amounts in hypertensive dogs and reacts with renin-activator to produce angiotonin and since the conditions of the experiment are such as to enhance greatly the sensitivity of the ear preparation to angiotonin, it is believed that the vasoconstriction is the result of the presence of angiotonin in the peripheral blood.	Angiotensin Amide	253-263	renin	Canis lupus familiaris	6-11
19870977-6	1940	Repeated intravenous injections of angiotonin into animals causes the pressor response gradually to lessen and finally to disappear (the phenomenon of tachyphylaxis), but much more slowly than when renin is injected.	Angiotensin Amide	35-45	renin	Canis lupus familiaris	198-203
19870977-8	1940	Large doses of renin reduce and finally abolish the responsiveness to angiotonin.	Angiotensin Amide	70-80	renin	Canis lupus familiaris	15-20
30126722-0	2018	Evaluation of the inhibitory effects of telmisartan on drug-induced renin-angiotensin-aldosterone system activation in normal dogs.	Telmisartan	40-51	renin	Canis lupus familiaris	68-73
31729111-1	2020	BACKGROUND: The renin-angiotensin-aldosterone system (RAAS) is activated in humans with portal hypertension (PH) associated with liver disease.	Aldosterone	22-45	renin	Canis lupus familiaris	16-21
31729111-7	2020	RESULTS: Plasma renin activity was significantly higher in the CH group (median, 4.4 ng/mL/h) than in the EH-CPSS (median, 1.0 ng/mL/h; P < .01) and the healthy (median, 1.1 ng/mL/h; P < .01) groups.	JMV 641	63-65	renin	Canis lupus familiaris	16-21
31769114-0	2020	Role of electrolyte concentrations and renin-angiotensin-aldosterone activation in the staging of canine heart disease.	Aldosterone	45-68	renin	Canis lupus familiaris	39-44
31769114-2	2020	OBJECTIVES: To characterize renal function, electrolyte concentrations, indices of diuretic efficacy, and renin-angiotensin-aldosterone system (RAAS) activation in dogs with naturally occurring heart disease (HD) in American College of Veterinary Internal Medicine stages B1, B2, C, and D and to determine their usefulness in defining HD stages.	Aldosterone	112-135	renin	Canis lupus familiaris	106-111
31809955-0	2019	Comparison between the effects of torsemide and furosemide on the renin-angiotensin-aldosterone system of normal dogs.	Furosemide	48-58	renin	Canis lupus familiaris	66-71
31809955-0	2019	Comparison between the effects of torsemide and furosemide on the renin-angiotensin-aldosterone system of normal dogs.	angiotensin-aldosterone	72-95	renin	Canis lupus familiaris	66-71
31809955-1	2019	INTRODUCTION/OBJECTIVES: We hypothesized that torsemide and furosemide, at approximately equipotent dosages (similar diuresis), would have comparable effects on the circulating renin-angiotensin-aldosterone system.	Torsemide	46-55	renin	Canis lupus familiaris	177-182
31809955-1	2019	INTRODUCTION/OBJECTIVES: We hypothesized that torsemide and furosemide, at approximately equipotent dosages (similar diuresis), would have comparable effects on the circulating renin-angiotensin-aldosterone system.	Furosemide	60-70	renin	Canis lupus familiaris	177-182
31809955-11	2019	CONCLUSIONS: At approximately equipotent dosages (20:1), torsemide and furosemide produced comparable renin-angiotensin-aldosterone system activation.	Torsemide	57-66	renin	Canis lupus familiaris	102-107
31809955-11	2019	CONCLUSIONS: At approximately equipotent dosages (20:1), torsemide and furosemide produced comparable renin-angiotensin-aldosterone system activation.	Furosemide	71-81	renin	Canis lupus familiaris	102-107
31254308-3	2019	Equilibrium concentrations of renin angiotensin aldosterone system (RAAS) APs differ in dogs with heart disease compared to healthy dogs and recombinant human ACE2 (rhACE2) alters relative concentrations of APs.	angiotensin aldosterone	36-59	renin	Canis lupus familiaris	30-35
31254308-3	2019	Equilibrium concentrations of renin angiotensin aldosterone system (RAAS) APs differ in dogs with heart disease compared to healthy dogs and recombinant human ACE2 (rhACE2) alters relative concentrations of APs.	rhace2	165-171	renin	Canis lupus familiaris	30-35
4724467-0	1973	[The influence of mannitol and furosemide on plasma renin activity in dogs with expansion of the extracellular volume].	Mannitol	18-26	renin	Canis lupus familiaris	52-57
4724467-0	1973	[The influence of mannitol and furosemide on plasma renin activity in dogs with expansion of the extracellular volume].	Furosemide	31-41	renin	Canis lupus familiaris	52-57
30508581-7	2019	Additionally, sacubitril/valsartan (675 mg) and valsartan significantly increased plasma renin activity, angiotensin I and angiotensin II concentrations.	sacubitril and valsartan sodium hydrate drug combination	14-24	renin	Canis lupus familiaris	89-94
30508581-7	2019	Additionally, sacubitril/valsartan (675 mg) and valsartan significantly increased plasma renin activity, angiotensin I and angiotensin II concentrations.	Valsartan	25-34	renin	Canis lupus familiaris	89-94
30508581-7	2019	Additionally, sacubitril/valsartan (675 mg) and valsartan significantly increased plasma renin activity, angiotensin I and angiotensin II concentrations.	Valsartan	48-57	renin	Canis lupus familiaris	89-94
30508581-10	2019	Sacubitril/valsartan favorably modulates the dynamics of the renin and NP cascades through complementary NEP and RAAS inhibition.	sacubitril and valsartan sodium hydrate drug combination	0-10	renin	Canis lupus familiaris	61-66
30508581-10	2019	Sacubitril/valsartan favorably modulates the dynamics of the renin and NP cascades through complementary NEP and RAAS inhibition.	Valsartan	11-20	renin	Canis lupus familiaris	61-66
30126722-1	2018	INTRODUCTION: This study examined whether the angiotensin II receptor blocker telmisartan had inhibitory effects on drug-induced renin-angiotensin-aldosterone system (RAAS) activation in normal dogs.	Telmisartan	78-89	renin	Canis lupus familiaris	129-134
30126722-7	2018	Plasma renin activity was significantly increased on days 1, 7, 28, 56, and 84 during telmisartan administration (all p=0.04).	Telmisartan	86-97	renin	Canis lupus familiaris	7-12
27166146-2	2016	While furosemide is a loop diuretic prescribed for the majority of CHF patients to reduce fluid retention, it also activates the renin-angiotensin aldosterone system (RAAS) which further contributes to the accelerated progression of heart failure.	Furosemide	6-16	renin	Canis lupus familiaris	129-134
27840084-11	2017	CONCLUSIONS: Diuresis was similar for both furosemide CRI methods; however, the H-SAL method induced less renin-angiotensin-aldosterone system activation than the DEX method.	h-sal	80-85	renin	Canis lupus familiaris	106-111
27401739-1	2017	Aliskiren, a direct renin inhibitor is expected to achieve sufficient suppression of renin-angiotensin system.	aliskiren	0-9	renin	Canis lupus familiaris	20-25
27401739-1	2017	Aliskiren, a direct renin inhibitor is expected to achieve sufficient suppression of renin-angiotensin system.	aliskiren	0-9	renin	Canis lupus familiaris	85-90
27302598-8	2017	Administration of furosemide induced diuresis, reduced GFR and activated the renin-aldosterone-angiotensin system.	Furosemide	18-28	renin	Canis lupus familiaris	77-82
25771846-0	2015	The effect of enalapril on furosemide-activated renin-angiotensin-aldosterone system in healthy dogs.	Enalapril	14-23	renin	Canis lupus familiaris	48-53
25771846-0	2015	The effect of enalapril on furosemide-activated renin-angiotensin-aldosterone system in healthy dogs.	Furosemide	27-37	renin	Canis lupus familiaris	48-53
23551840-9	2013	Furthermore, in vivo cTnI concentrations reflected postmortem findings of global myocardial fibrosis (P < .001), fibrosis in the papillary muscles (P < .001), and degree of arterial luminal narrowing (P < .001) Aldosterone or renin activity did not reflect any of the cardiac disease variables investigated.	ctni	21-25	renin	Canis lupus familiaris	235-240
24496516-0	2014	Effects of renal sympathetic denervation using saline-irrigated radiofrequency ablation catheter on the activity of the renin-angiotensin system and endothelin-1.	Sodium Chloride	47-53	renin	Canis lupus familiaris	120-125
24935941-3	2014	As the sensitivity of arterial pressure to salt intake is linked to the responsiveness of renin secretion, we determined steady-state levels of arterial pressure and neurohormonal responses in 6 dogs on low, normal, and high salt intakes (5, 40, 450 mmol/d, respectively) under control conditions and during a 7-day constant level of BA.	Salts	43-47	renin	Canis lupus familiaris	90-95
23931032-5	2013	The present studies were designed to explore the circadian variations of plasma renin activity (RA) and urinary aldosterone-to-creatinine ratio (UA:C) in relation to blood pressure (BP), sodium (UNa, UNa,fe), and potassium (UK, UK,fe) renal handling.	Sodium	187-193	renin	Canis lupus familiaris	80-85
23931032-13	2013	The postprandial decrease in RA is assumed to be related to body fluid volume expansion secondary to water and sodium intake, whereas the reduction of UA:C reflects aldosterone-stimulated secretion by the renin-angiotensin II pathway.	Aldosterone	165-176	renin	Canis lupus familiaris	205-210
23931032-19	2013	Specifically, sodium intake was found to interact with the tonic and the phasic secretion of renin, suggesting that varying feeding time could also impact the chronobiology of the renin cascade.	Sodium	14-20	renin	Canis lupus familiaris	93-98
23931032-19	2013	Specifically, sodium intake was found to interact with the tonic and the phasic secretion of renin, suggesting that varying feeding time could also impact the chronobiology of the renin cascade.	Sodium	14-20	renin	Canis lupus familiaris	180-185
23952288-8	2013	Plasma renin activity and plasma aldosterone were significantly lower after the administration of carperitide than after the administration of furosemide (P < .05, respectively).	NPPA protein, human	98-109	renin	Canis lupus familiaris	7-12
23952288-8	2013	Plasma renin activity and plasma aldosterone were significantly lower after the administration of carperitide than after the administration of furosemide (P < .05, respectively).	Furosemide	143-153	renin	Canis lupus familiaris	7-12
22869391-12	2012	The plasma aldosterone concentration increased significantly 7 h after rapid pacing in control group (renin, 119.8 +- 31.1 vs 185.3 +- 103.5 pg/ml, P < 0.01; aldosterone, 288.2 +- 43.1 vs 369.6 +- 109.8 pg/ml, P = 0.01).	Aldosterone	11-22	renin	Canis lupus familiaris	102-107
22568394-0	2013	Capturing the dynamics of systemic Renin-Angiotensin-Aldosterone System (RAAS) peptides heightens the understanding of the effect of benazepril in dogs.	benazepril	133-143	renin	Canis lupus familiaris	35-40