PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
25762621-6	2015	miR-145 inhibition consistently abrogates the 1,25(OH)2D3-mediated suppression of E2F3, CDK6, CDK2 and CCNA2 genes.	mir-145	0-7	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	94-98
25762621-6	2015	miR-145 inhibition consistently abrogates the 1,25(OH)2D3-mediated suppression of E2F3, CDK6, CDK2 and CCNA2 genes.	Calcitriol	46-57	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	94-98
10679579-3	2000	Two phorbol esters, 4-beta-phorbol 12-myristate-13-acetate (PMA) and 4-beta-phorbol 12,13-dibutyrate (PDBu); the cGMP-dependent PK activators sodium nitroprusside (SNP) and S-nitrosoglutathione (SNOG); and the PP inhibitor okadaic acid (OA) reduced the amplitude of the GABA-induced currents, whilst the PK inhibitor staurosporine potentiated it.	Tetradecanoylphorbol Acetate	60-63	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	128-130
22185819-7	2012	Moreover, constitutive expression of exogenous E2F1 prevented the artemisinin-induced cell cycle arrest and downregulation of CDK2 and cyclin E gene expression.	artemisinin	66-77	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	126-130
15381253-4	2004	Pretreatment of core protein-expressing cells with the inhibitor of CDK2, Butyrolactone I, abolished the phosphorylation of Rb, the activation of E2F-1, and inhibited the expression of E2F-1 gene and cell growth induced.	4-Butyrolactone	74-87	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	68-72
11257126-2	2001	In the first phase, the origin recognition complex and Cdc6 prereplication proteins, but not the minichromosome maintenance complex, are necessary and biochemically sufficient for ATP-dependent binding of cyclin E--Cdk2 to DNA.	Adenosine Triphosphate	180-183	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	215-219
10982403-10	2000	Furthermore, overexpression of XChk1 in Xenopus embryos creates a checkpoint in which cell division arrests, and both Cdc2 and Cdk2 are phosphorylated on tyrosine 15 and inhibited in catalytic activity.	Tyrosine	154-162	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	127-131
25627688-8	2015	In addition, roscovitine (Cdk1/2/5 inhibitor) or CINK4 (Cdk4/6 inhibitor) could inhibit the phosphorylation of Tudor-SN, whereas ectopic overexpression of Cdk2/4/6 increased the Tudor-SN phosphorylation.	Roscovitine	13-24	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	155-163
25627688-8	2015	In addition, roscovitine (Cdk1/2/5 inhibitor) or CINK4 (Cdk4/6 inhibitor) could inhibit the phosphorylation of Tudor-SN, whereas ectopic overexpression of Cdk2/4/6 increased the Tudor-SN phosphorylation.	CINK4	49-54	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	155-163
23607668-6	2013	Additionally, during interphase, Xic2 is phosphorylated by CDK2 at Ser-98 and Ser-131 in a DNA-independent manner, inhibiting Xic2 turnover.	Serine	67-70	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	59-63
12176996-4	2002	Moreover, Delta N-cyclin A2-Cdk2 has an expanded substrate specificity and can phosphorylate histone H2B at Ser-32, which may facilitate DNA cleavage.	Serine	108-111	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	28-32
11461916-2	2001	Cdk1 (Cdc2) and Cdk2 should be bound to regulatory subunits named cyclins as well as phosphorylated on a conserved Thr located in the T-loop for full enzymatic activity.	Threonine	115-118	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	16-20
11461916-3	2001	Cdc2- and Cdk2-cyclin complexes can be inactivated by phosphorylation on the catalytic cleft-located Thr-14 and Tyr-15 residues or by association with inhibitory subunits such as p21(Cip1).	Threonine	101-104	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	10-14
11461916-3	2001	Cdc2- and Cdk2-cyclin complexes can be inactivated by phosphorylation on the catalytic cleft-located Thr-14 and Tyr-15 residues or by association with inhibitory subunits such as p21(Cip1).	Tyrosine	112-115	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	10-14
11461916-7	2001	We also show that RINGO can directly stimulate the kinase activity of Cdk2 independently of Thr-160 phosphorylation.	Threonine	92-95	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	70-74
11030344-6	2000	Cdk2/CyclinE acts downstream of ATM and is downregulated by Cdk2 phosphorylation on tyrosine 15.	Tyrosine	84-92	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	0-4
11030344-6	2000	Cdk2/CyclinE acts downstream of ATM and is downregulated by Cdk2 phosphorylation on tyrosine 15.	Tyrosine	84-92	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	60-64
10679579-3	2000	Two phorbol esters, 4-beta-phorbol 12-myristate-13-acetate (PMA) and 4-beta-phorbol 12,13-dibutyrate (PDBu); the cGMP-dependent PK activators sodium nitroprusside (SNP) and S-nitrosoglutathione (SNOG); and the PP inhibitor okadaic acid (OA) reduced the amplitude of the GABA-induced currents, whilst the PK inhibitor staurosporine potentiated it.	Cyclic GMP	113-117	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	128-130
10679579-3	2000	Two phorbol esters, 4-beta-phorbol 12-myristate-13-acetate (PMA) and 4-beta-phorbol 12,13-dibutyrate (PDBu); the cGMP-dependent PK activators sodium nitroprusside (SNP) and S-nitrosoglutathione (SNOG); and the PP inhibitor okadaic acid (OA) reduced the amplitude of the GABA-induced currents, whilst the PK inhibitor staurosporine potentiated it.	Cyclic GMP	113-117	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	304-306
10679579-3	2000	Two phorbol esters, 4-beta-phorbol 12-myristate-13-acetate (PMA) and 4-beta-phorbol 12,13-dibutyrate (PDBu); the cGMP-dependent PK activators sodium nitroprusside (SNP) and S-nitrosoglutathione (SNOG); and the PP inhibitor okadaic acid (OA) reduced the amplitude of the GABA-induced currents, whilst the PK inhibitor staurosporine potentiated it.	Nitroprusside	142-162	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	128-130
10679579-3	2000	Two phorbol esters, 4-beta-phorbol 12-myristate-13-acetate (PMA) and 4-beta-phorbol 12,13-dibutyrate (PDBu); the cGMP-dependent PK activators sodium nitroprusside (SNP) and S-nitrosoglutathione (SNOG); and the PP inhibitor okadaic acid (OA) reduced the amplitude of the GABA-induced currents, whilst the PK inhibitor staurosporine potentiated it.	S-Nitrosoglutathione	173-193	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	128-130
10679579-3	2000	Two phorbol esters, 4-beta-phorbol 12-myristate-13-acetate (PMA) and 4-beta-phorbol 12,13-dibutyrate (PDBu); the cGMP-dependent PK activators sodium nitroprusside (SNP) and S-nitrosoglutathione (SNOG); and the PP inhibitor okadaic acid (OA) reduced the amplitude of the GABA-induced currents, whilst the PK inhibitor staurosporine potentiated it.	S-Nitrosoglutathione	195-199	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	128-130
10679579-3	2000	Two phorbol esters, 4-beta-phorbol 12-myristate-13-acetate (PMA) and 4-beta-phorbol 12,13-dibutyrate (PDBu); the cGMP-dependent PK activators sodium nitroprusside (SNP) and S-nitrosoglutathione (SNOG); and the PP inhibitor okadaic acid (OA) reduced the amplitude of the GABA-induced currents, whilst the PK inhibitor staurosporine potentiated it.	Okadaic Acid	223-235	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	128-130
10679579-3	2000	Two phorbol esters, 4-beta-phorbol 12-myristate-13-acetate (PMA) and 4-beta-phorbol 12,13-dibutyrate (PDBu); the cGMP-dependent PK activators sodium nitroprusside (SNP) and S-nitrosoglutathione (SNOG); and the PP inhibitor okadaic acid (OA) reduced the amplitude of the GABA-induced currents, whilst the PK inhibitor staurosporine potentiated it.	Okadaic Acid	237-239	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	128-130
10679579-3	2000	Two phorbol esters, 4-beta-phorbol 12-myristate-13-acetate (PMA) and 4-beta-phorbol 12,13-dibutyrate (PDBu); the cGMP-dependent PK activators sodium nitroprusside (SNP) and S-nitrosoglutathione (SNOG); and the PP inhibitor okadaic acid (OA) reduced the amplitude of the GABA-induced currents, whilst the PK inhibitor staurosporine potentiated it.	gamma-Aminobutyric Acid	270-274	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	128-130
10679579-3	2000	Two phorbol esters, 4-beta-phorbol 12-myristate-13-acetate (PMA) and 4-beta-phorbol 12,13-dibutyrate (PDBu); the cGMP-dependent PK activators sodium nitroprusside (SNP) and S-nitrosoglutathione (SNOG); and the PP inhibitor okadaic acid (OA) reduced the amplitude of the GABA-induced currents, whilst the PK inhibitor staurosporine potentiated it.	Staurosporine	317-330	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	128-130
9233796-2	1997	Cdk2 kinase, a G1/S regulator in higher eukaryotic cells, is activated during meiotic maturation of Xenopus oocytes and, like Mos (an essential component of CSF), is proposed to be involved in metaphase II arrest in mature oocytes.	Molybdenum	126-129	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	0-4
10433828-7	1999	Western blotting with an antibody specific for phosphorylated tyr15 in Cdc2/Cdk2 revealed a cycle of phosphorylation/dephosphorylation in each cell cycle in control embryos, and in embryos injected with phosphatase-dead Cdc25A there was a twofold increase in the level of p-tyr in Cdc2/Cdk2.	Tyrosine	62-65	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	76-80
10433828-7	1999	Western blotting with an antibody specific for phosphorylated tyr15 in Cdc2/Cdk2 revealed a cycle of phosphorylation/dephosphorylation in each cell cycle in control embryos, and in embryos injected with phosphatase-dead Cdc25A there was a twofold increase in the level of p-tyr in Cdc2/Cdk2.	Tyrosine	62-65	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	286-290
9632717-7	1998	Moreover, the activation of Cdk2 was not affected under the conditions where DNA replication was blocked by actinomycin D.	Dactinomycin	108-121	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	28-32
8756624-2	1996	We report that there are two copies of a cyclin-binding motif in p21, Cy1 and Cy2, which interact with the cyclins independently of Cdk2.	cy1	70-73	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	132-136
8756624-2	1996	We report that there are two copies of a cyclin-binding motif in p21, Cy1 and Cy2, which interact with the cyclins independently of Cdk2.	CY2	78-81	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	132-136
7657707-5	1995	An ATP-binding-site mutant cdk2 mRNA (cdk2.R33) failed to stimulate replication and inhibited S phase initiation in mock-depleted extracts.	Adenosine Triphosphate	3-6	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	27-31
7657707-5	1995	An ATP-binding-site mutant cdk2 mRNA (cdk2.R33) failed to stimulate replication and inhibited S phase initiation in mock-depleted extracts.	Adenosine Triphosphate	3-6	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	38-42
1517236-10	1992	These results demonstrate that cdk2 is regulated in the cell cycle by phosphorylation and dephosphorylation on both serine and tyrosine residues.	Serine	116-122	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	31-35
8500762-5	1993	The primary sequence of Eh cdc2 is most like those of cdc2 homologues Eg1 of Xenopus laevis and CDK2 of man (52% aa identity with each) and codes for (i) the serine (Ser), threonine (Thr), and tyrosine residues phosphorylated in p34cdc2 proteins, (ii) 32 of 33 aa conserved in other Ser/Thr protein kinases, and (iii) the sequence PVTSVRE instead of PSTAIRE found in most p34cdc2 proteins.	Serine	158-164	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	96-100
8500762-5	1993	The primary sequence of Eh cdc2 is most like those of cdc2 homologues Eg1 of Xenopus laevis and CDK2 of man (52% aa identity with each) and codes for (i) the serine (Ser), threonine (Thr), and tyrosine residues phosphorylated in p34cdc2 proteins, (ii) 32 of 33 aa conserved in other Ser/Thr protein kinases, and (iii) the sequence PVTSVRE instead of PSTAIRE found in most p34cdc2 proteins.	Serine	166-169	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	96-100
1517236-4	1992	Upon exit from metaphase, cdk2 became increasingly phosphorylated on both tyrosine and serine residues, and labeling on these residues increased progressively until entry into mitosis, when tyrosine residues were markedly dephosphorylated.	Tyrosine	74-82	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	26-30
1517236-4	1992	Upon exit from metaphase, cdk2 became increasingly phosphorylated on both tyrosine and serine residues, and labeling on these residues increased progressively until entry into mitosis, when tyrosine residues were markedly dephosphorylated.	Serine	87-93	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	26-30
1517236-5	1992	Phosphopeptide mapping of cdk2 demonstrated the major sites of phosphorylation were in a phosphopeptide with a pI of 3.7 that contained both phosphoserine and phosphotyrosine.	Phosphoserine	141-154	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	26-30
1517236-5	1992	Phosphopeptide mapping of cdk2 demonstrated the major sites of phosphorylation were in a phosphopeptide with a pI of 3.7 that contained both phosphoserine and phosphotyrosine.	Phosphotyrosine	159-174	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	26-30
8065320-8	1994	When fused to CAT RNA, the cdk2 3" untranslated region, which contains these elements, as well as the CPE and the hexanucleotide, promoted poly(A) addition and enhanced chloramphenicol acetyltransferase activity during maturation, as well as repression of these events after fertilization.	Poly A	139-146	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	27-31
8065320-9	1994	Incubation of fertilized eggs with cycloheximide prevented the embryonic inhibition of cdk2 RNA polyadenylation but did not affect the robust polyadenylation of B4 RNA.	Cycloheximide	35-48	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	87-91
1517236-10	1992	These results demonstrate that cdk2 is regulated in the cell cycle by phosphorylation and dephosphorylation on both serine and tyrosine residues.	Tyrosine	127-135	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	31-35
1517236-11	1992	Moreover, the increased phosphorylation of cdk2 in aphidicolin-blocked extracts and the ability of cdc25 to mediate cdk2 dephosphorylation in vitro suggest the possibility that cdk2 is part of the mechanism ensuring mitosis is not initiated until completion of DNA replication.	Aphidicolin	51-62	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	43-47
34461908-10	2021	Moreover, the expression of the cell cycle-related proteins CDK2/4/6, Cyclin D1 and Cyclin A1 + A2 was significantly increased and p21 expression was decreased after avasimibe treatment.	avasimibe	166-175	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	60-68
1339336-7	1992	Anti-cdk2 immunoprecipitates from 32P-labeled mature oocyte extracts contained a 47-kDa protein, which was not recognized by either anti-cyclin A or anti-cyclin B antibody, indicating complex formation of cdk2 with a protein other than cyclins A or B.	Phosphorus-32	34-37	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	5-9
1339336-7	1992	Anti-cdk2 immunoprecipitates from 32P-labeled mature oocyte extracts contained a 47-kDa protein, which was not recognized by either anti-cyclin A or anti-cyclin B antibody, indicating complex formation of cdk2 with a protein other than cyclins A or B.	Phosphorus-32	34-37	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	205-209
1309805-2	1992	We show here that the Eg1 gene product (cdk2) possesses histone H1 protein kinase activity and binds to PSTAIR antibodies as well as to Sepharose beads linked to the 13-kDa product of the suc 1 gene (p13suc1).	Sepharose	136-145	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	22-25
1309805-2	1992	We show here that the Eg1 gene product (cdk2) possesses histone H1 protein kinase activity and binds to PSTAIR antibodies as well as to Sepharose beads linked to the 13-kDa product of the suc 1 gene (p13suc1).	Sepharose	136-145	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	40-44
1704128-10	1991	Eg1 RNA is found in the poly(A)+ fraction of oocytes only between the time of meiotic maturation and fertilization--that is to say, in the unfertilized egg.	Poly A	24-31	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	0-3
6196057-1	1983	The RNA-binding proteins from amphibian (Rana temporaria and Xenopus laevis) oocytes contain a cAMP-independent caseintype protein kinase activity.	Cyclic AMP	95-99	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	123-137
28305429-7	1988	This suggests that besides cAMP/cGMP dependent protein kinases protein kinase C or related enzymes are involved in the neural induction and differentiation processes.	Cyclic AMP	27-31	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	47-61
28305429-8	1988	This corresponds to previous experiments which have shown that treatment of ectoderm with phorbol myristate acetate, an activator of protein kinase C and protein kinase C related enzymes, initiates neural differentiation.	Tetradecanoylphorbol Acetate	90-115	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	133-147
28305429-8	1988	This corresponds to previous experiments which have shown that treatment of ectoderm with phorbol myristate acetate, an activator of protein kinase C and protein kinase C related enzymes, initiates neural differentiation.	Tetradecanoylphorbol Acetate	90-115	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	154-168
6196057-4	1983	Protein kinase retains the ability to bind poly(U) under physiological ionic strength values.	Poly U	43-50	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	0-14
32582992-7	2020	Significant changes in the E2F1/Cdc25a/Cdk2 pathway in the RB cells were detected by RNA-seq following carboplatin or lobaplatin intervention.	Carboplatin	103-114	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	39-43
32582992-7	2020	Significant changes in the E2F1/Cdc25a/Cdk2 pathway in the RB cells were detected by RNA-seq following carboplatin or lobaplatin intervention.	lobaplatin	118-128	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	39-43