PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 16288018-5 2005 Enhanced expression of DDB2 improved repair of both CPDs and pyrimidine(6-4)pyrimidone photoproducts (6-4PP) in dermal fibroblasts. pyrimidine(6-4)pyrimidone 61-86 damage specific DNA binding protein 2 Mus musculus 23-27 16288018-5 2005 Enhanced expression of DDB2 improved repair of both CPDs and pyrimidine(6-4)pyrimidone photoproducts (6-4PP) in dermal fibroblasts. 6-4pp 102-107 damage specific DNA binding protein 2 Mus musculus 23-27 16288018-9 2005 On the cellular level, we detected a delay in the repair of 6-4PPs in DDB2-/- dermal fibroblasts. 6-4pps 60-66 damage specific DNA binding protein 2 Mus musculus 70-74 12107171-7 2002 Significantly, overexpression of c-Abl increased tyrosine phosphorylation of DDB2 and suppressed UV-DDB activity. Tyrosine 49-57 damage specific DNA binding protein 2 Mus musculus 77-81 12107171-8 2002 Conversely, a dominant negative, kinase-deficient allele of c-Abl decreased tyrosine phosphorylation of DDB2 and dramatically stimulated UV-DDB activity. Tyrosine 76-84 damage specific DNA binding protein 2 Mus musculus 104-108 35428778-8 2022 Administration of pevonedistat to mice bearing HNSCC tumors significantly decreased DDB2 expression in tumor cells, increased DNA damage and potently enhanced the activity of cisplatin to yield tumor regression and long-term survival of all animals. pevonedistat 18-30 damage specific DNA binding protein 2 Mus musculus 84-88 23604128-3 2014 We show that drug-induced resistance is a result of p53-dependent upregulation of the nucleotide excision repair (NER) genes xeroderma pigmentosum complementation group C (XPC) and damaged DNA-binding protein 2 (DDB2), which stimulate the repair of DNA interstrand cross-links (ICLs) arising from O(6)-chloroethylguanine. o(6)-chloroethylguanine 297-320 damage specific DNA binding protein 2 Mus musculus 212-216 23604128-9 2014 Additionally, XPC and DDB2 induction occurred upon treatment with other cross-linking anticancer drugs, such as cisplatin and mafosfamide, indicating it is a general response of cancer cells to this group of chemotherapeutics. Cisplatin 112-121 damage specific DNA binding protein 2 Mus musculus 22-26 23604128-9 2014 Additionally, XPC and DDB2 induction occurred upon treatment with other cross-linking anticancer drugs, such as cisplatin and mafosfamide, indicating it is a general response of cancer cells to this group of chemotherapeutics. mafosfamide 126-137 damage specific DNA binding protein 2 Mus musculus 22-26