PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32777257-0	2020	Fas and GIT1 Signalling in the Prefrontal Cortex Mediate Behavioural Sensitization to Methamphetamine in Mice.	Methamphetamine	86-101	GIT ArfGAP 1	Mus musculus	8-12
32777257-11	2020	Western blot analysis revealed decreased Fas, GIT1, MEK1 and phosphorylated CREB levels and increased phosphorylated Erk1/2 levels in METH-sensitized mice.	Methamphetamine	134-138	GIT ArfGAP 1	Mus musculus	46-50
32777257-12	2020	Injection of Fas and GIT1 injection showed that overexpression of Fas and GIT1 inhibited the induction of METH sensitization and reversed the changes in neurotransmitter levels and related protein levels, including MEK1, phosphorylated CREB and phosphorylated Erk1/2, in METH-sensitized mice.	Methamphetamine	106-110	GIT ArfGAP 1	Mus musculus	21-25
32777257-12	2020	Injection of Fas and GIT1 injection showed that overexpression of Fas and GIT1 inhibited the induction of METH sensitization and reversed the changes in neurotransmitter levels and related protein levels, including MEK1, phosphorylated CREB and phosphorylated Erk1/2, in METH-sensitized mice.	Methamphetamine	106-110	GIT ArfGAP 1	Mus musculus	74-78
32777257-12	2020	Injection of Fas and GIT1 injection showed that overexpression of Fas and GIT1 inhibited the induction of METH sensitization and reversed the changes in neurotransmitter levels and related protein levels, including MEK1, phosphorylated CREB and phosphorylated Erk1/2, in METH-sensitized mice.	Methamphetamine	271-275	GIT ArfGAP 1	Mus musculus	21-25
32777257-12	2020	Injection of Fas and GIT1 injection showed that overexpression of Fas and GIT1 inhibited the induction of METH sensitization and reversed the changes in neurotransmitter levels and related protein levels, including MEK1, phosphorylated CREB and phosphorylated Erk1/2, in METH-sensitized mice.	Methamphetamine	271-275	GIT ArfGAP 1	Mus musculus	74-78
32777257-13	2020	Overexpression of Fas and GIT1 also reduced histological lesions induced by METH.	Methamphetamine	76-80	GIT ArfGAP 1	Mus musculus	26-30
32777257-14	2020	CONCLUSION: The findings indicated that the development of behavioural sensitization to METH may be mediated by Fas and GIT1 through the MEK1-Erk1/2-CREB pathway.	Methamphetamine	88-92	GIT ArfGAP 1	Mus musculus	120-124
29554125-2	2018	Mice lacking GIT1 have been proposed as a model for attention deficit-hyperactivity disorder, due to alterations in basal locomotor activity as well as paradoxical locomotor suppression by the psychostimulant amphetamine.	Amphetamine	209-220	GIT ArfGAP 1	Mus musculus	13-17
28912643-7	2017	Therefore, we investigated the changes in the amount of GABA and degree of tonic inhibition in GIT1 KO mice.	gamma-Aminobutyric Acid	56-60	GIT ArfGAP 1	Mus musculus	95-99
28912643-8	2017	We observed a decreased glial GABA intensity in GIT1 KO mice compared to wild type (WT) mice and an attenuation of tonic current from cerebellar granule cells in GIT1 KO mice.	gamma-Aminobutyric Acid	30-34	GIT ArfGAP 1	Mus musculus	48-52
27690640-5	2016	CAT1 overproduction did not change the minimum inhibitory concentration of fungal cells to fungistatic or fungicidal azoles nor to amphotericin B although increased twofold the minimum inhibitory concentration to caspofungin.	Caspofungin	213-224	GIT ArfGAP 1	Mus musculus	0-4
26113791-4	2015	The abnormal thalamic oscillation and thalamocortical synchrony in Git1 (-/-) mice were markedly reduced by amphetamine.	Amphetamine	108-119	GIT ArfGAP 1	Mus musculus	67-71
26113791-5	2015	In addition, ethosuximide ameliorates abnormal thalamic oscillation and ADHD-like hyperactivity shown in Git1 (-/-) mice.	Ethosuximide	13-25	GIT ArfGAP 1	Mus musculus	105-109
25821222-10	2015	Moreover, in activated BMMCs, gamma-tubulin formed complexes with tyrosine-phosphorylated GIT1.	Tyrosine	66-74	GIT ArfGAP 1	Mus musculus	90-94
25742295-0	2015	Specific dephosphorylation at tyr-554 of git1 by ptprz promotes its association with paxillin and hic-5.	Tyrosine	30-33	GIT ArfGAP 1	Mus musculus	41-45
25742295-2	2015	We previously demonstrated that Git1 was a multiply tyrosine-phosphorylated protein, its primary phosphorylation site was Tyr-554 in the vicinity of the focal adhesion targeting-homology (FAH) domain, and this site was selectively dephosphorylated by protein tyrosine phosphatase receptor type Z (Ptprz).	Tyrosine	52-60	GIT ArfGAP 1	Mus musculus	32-36
25742295-2	2015	We previously demonstrated that Git1 was a multiply tyrosine-phosphorylated protein, its primary phosphorylation site was Tyr-554 in the vicinity of the focal adhesion targeting-homology (FAH) domain, and this site was selectively dephosphorylated by protein tyrosine phosphatase receptor type Z (Ptprz).	Tyrosine	122-125	GIT ArfGAP 1	Mus musculus	32-36
25742295-3	2015	In the present study, we showed that Tyr-554 phosphorylation reduced the association of Git1 with the FAH-domain-binding proteins, paxillin and Hic-5, based on immunoprecipitation experiments using the Tyr-554 mutants of Git1.	Tyrosine	37-40	GIT ArfGAP 1	Mus musculus	88-92
25742295-3	2015	In the present study, we showed that Tyr-554 phosphorylation reduced the association of Git1 with the FAH-domain-binding proteins, paxillin and Hic-5, based on immunoprecipitation experiments using the Tyr-554 mutants of Git1.	Tyrosine	37-40	GIT ArfGAP 1	Mus musculus	221-225
25742295-3	2015	In the present study, we showed that Tyr-554 phosphorylation reduced the association of Git1 with the FAH-domain-binding proteins, paxillin and Hic-5, based on immunoprecipitation experiments using the Tyr-554 mutants of Git1.	Tyrosine	202-205	GIT ArfGAP 1	Mus musculus	88-92
25742295-4	2015	The Tyr-554 phosphorylation of Git1 was higher, and its binding to paxillin was consistently lower in the brains of Ptprz-deficient mice than in those of wild-type mice.	Tyrosine	4-7	GIT ArfGAP 1	Mus musculus	31-35
25742295-7	2015	The motility defect was rescued by the exogenous expression of wild-type Git1 and a Git1 mutant, which only retained Tyr-554 among the multiple potential tyrosine phosphorylation sites, but not by the Tyr-554 phosphorylation-defective or phosphorylation-state mimic Git1 mutant.	Tyrosine	117-120	GIT ArfGAP 1	Mus musculus	84-88
25742295-7	2015	The motility defect was rescued by the exogenous expression of wild-type Git1 and a Git1 mutant, which only retained Tyr-554 among the multiple potential tyrosine phosphorylation sites, but not by the Tyr-554 phosphorylation-defective or phosphorylation-state mimic Git1 mutant.	Tyrosine	117-120	GIT ArfGAP 1	Mus musculus	84-88
25742295-7	2015	The motility defect was rescued by the exogenous expression of wild-type Git1 and a Git1 mutant, which only retained Tyr-554 among the multiple potential tyrosine phosphorylation sites, but not by the Tyr-554 phosphorylation-defective or phosphorylation-state mimic Git1 mutant.	Tyrosine	154-162	GIT ArfGAP 1	Mus musculus	84-88
25742295-7	2015	The motility defect was rescued by the exogenous expression of wild-type Git1 and a Git1 mutant, which only retained Tyr-554 among the multiple potential tyrosine phosphorylation sites, but not by the Tyr-554 phosphorylation-defective or phosphorylation-state mimic Git1 mutant.	Tyrosine	154-162	GIT ArfGAP 1	Mus musculus	84-88
25742295-8	2015	Our results suggested that cyclic phosphorylation-dephosphorylation at Tyr-554 of Git1 was crucial for dynamic interactions between Git1 and paxillin/Hic-5 in order to ensure coordinated cell motility.	Tyrosine	71-74	GIT ArfGAP 1	Mus musculus	82-86
25742295-8	2015	Our results suggested that cyclic phosphorylation-dephosphorylation at Tyr-554 of Git1 was crucial for dynamic interactions between Git1 and paxillin/Hic-5 in order to ensure coordinated cell motility.	Tyrosine	71-74	GIT ArfGAP 1	Mus musculus	132-136
24586541-5	2014	Alcian blue staining of fracture callus indicated a persistence of cartilagenous matrix in day 21 callus samples from GIT1 KO mice which was temporally correlated with increased type 2 collagen immunostaining.	Alcian Blue	0-11	GIT ArfGAP 1	Mus musculus	118-122
23430614-7	2013	In mouse aortic smooth muscle cells (MASM), we found that the growth rate and [3H]-thymidine incorporation of the GIT1 KO MASM were significantly decreased compared with the wild-type MASM.	Tritium	79-81	GIT ArfGAP 1	Mus musculus	114-118
23430614-7	2013	In mouse aortic smooth muscle cells (MASM), we found that the growth rate and [3H]-thymidine incorporation of the GIT1 KO MASM were significantly decreased compared with the wild-type MASM.	Thymidine	83-92	GIT ArfGAP 1	Mus musculus	114-118
21499268-5	2011	Hyperactivity in Git1(-/-) mice is reversed by amphetamine and methylphenidate, psychostimulants commonly used to treat ADHD.	Amphetamine	47-58	GIT ArfGAP 1	Mus musculus	17-21
21499268-5	2011	Hyperactivity in Git1(-/-) mice is reversed by amphetamine and methylphenidate, psychostimulants commonly used to treat ADHD.	Methylphenidate	63-78	GIT ArfGAP 1	Mus musculus	17-21
20568227-3	2010	Because GIT1 is tyrosine phosphorylated by Src kinase, we anticipated that GIT1 KO should have a bone phenotype similar to Src KO.	Tyrosine	16-24	GIT ArfGAP 1	Mus musculus	8-12
20568227-3	2010	Because GIT1 is tyrosine phosphorylated by Src kinase, we anticipated that GIT1 KO should have a bone phenotype similar to Src KO.	Tyrosine	16-24	GIT ArfGAP 1	Mus musculus	75-79
20568227-10	2010	Furthermore, we found that GIT1 was a regulator of receptor activator of NFkappaB (RANK) signaling since it was tyrosine phosphorylated in a Src-dependent manner and was required for phospholipase C-gamma2 phosphorylation.	Tyrosine	112-120	GIT ArfGAP 1	Mus musculus	27-31
18986306-6	2009	We provide evidence that phosphorylation of Ser(272) within LD(4) blocks nuclear export, and we show that this modification also reduces GIT1, but not FAK1, binding; however, Ser(272) phosphorylation does not appear to be mediated by PAK1 as previously suggested.	Serine	44-47	GIT ArfGAP 1	Mus musculus	137-141
15893751-6	2005	Transfection of the cells with specific p85 beta-PIX siRNA led to drastic inhibition of LPA-induced FAK phosphorylation, peripheral redistribution of p85 beta-PIX with FAK and GIT1, and cell motility.	lysophosphatidic acid	88-91	GIT ArfGAP 1	Mus musculus	176-180
15844139-1	2005	We used the membrane-impermeable nitroxyl radical 4-trimethylammonium-2,2,6,6-tetramethylpiperidine-1-oxyliodide (CAT-1) as a model drug encapsulated in liposomes in order to separately map the 2D distribution of both liposomal-encapsulated CAT-1 and free CAT-1.	nitroxyl radical 4-trimethylammonium-2,2,6,6-tetramethylpiperidine-1-oxyliodide	33-112	GIT ArfGAP 1	Mus musculus	114-119
15587923-3	2004	METHODS: Highly concentrated solutions of the spin probe 2,2,6,6-tetramethyl-4-trimethylammoniumpiperidine-1-oxyl-iodide (CAT-1; 138 mM) were encapsulated in liposomes.	2,2,6,6-tetramethyl-4-trimethylammoniumpiperidine-1-oxyl-iodide	57-120	GIT ArfGAP 1	Mus musculus	122-127
15038083-4	2004	VacA bound to Ptprz, and the tyrosine-phosphorylation level of Git1, a Ptprz substrate, was elevated by VacA, indicating that VacA behaves as a ligand for Ptprz.	Tyrosine	29-37	GIT ArfGAP 1	Mus musculus	63-67
9353056-7	1997	Molecular experiments reveal that CAT1 contains a signal peptide and a propeptide of 15 and 12 amino acid residues, respectively.	propeptide	71-81	GIT ArfGAP 1	Mus musculus	34-38
9353056-8	1997	cat1-disrupted mutants that were unable to produce the slow catalase were as sensitive to H2O2 and polymorphonuclear cells as the wild-type strain.	Hydrogen Peroxide	90-94	GIT ArfGAP 1	Mus musculus	0-4
1658535-1	1991	Liposomes containing the deuterated, charged, aqueous soluble nitroxide 4-trimethyl-ammonium-2,2,6,6-tetramethylpiperidine-d16-1-oxyl (d-Cat1) were used as probes to measure oxygen concentrations in vivo.	nitroxide 4-trimethyl-ammonium-2,2,6,6-tetramethylpiperidine-d16-1-oxyl	62-133	GIT ArfGAP 1	Mus musculus	137-141
3210953-1	1988	The positively charged nitroxide spin label, 2,2,6,6-tetramethyl-piperidine-N-oxyl-4-trimethylammonium (Cat1), was encapsulated in two types of liposomes, phosphatidylserine/phosphatidylcholine (PS/PC) and phosphatidylserine/distearoylphosphatidylcholine/dipalmitoylphosphatidyl choline (PS/DSPC/DPPC).	Hydroxylamine	23-32	GIT ArfGAP 1	Mus musculus	104-108
3210953-1	1988	The positively charged nitroxide spin label, 2,2,6,6-tetramethyl-piperidine-N-oxyl-4-trimethylammonium (Cat1), was encapsulated in two types of liposomes, phosphatidylserine/phosphatidylcholine (PS/PC) and phosphatidylserine/distearoylphosphatidylcholine/dipalmitoylphosphatidyl choline (PS/DSPC/DPPC).	2,2,6,6-tetramethyl-piperidine-n-oxyl-4-trimethylammonium	45-102	GIT ArfGAP 1	Mus musculus	104-108
3210953-5	1988	PS/PC liposomes interact predominantely with the plasma membrane of TB cells and release Cat1 continuously, whereas the majority of PS/DSPC/DPPC liposomes are taken into the cells intact via endocytosis.	Phosphorus	0-2	GIT ArfGAP 1	Mus musculus	89-93