PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
2611121-5	1989	Indomethacin administered as subcutaneously-implanted pellets did not influence the IL-1 beta induced-ear erythema, but suppressed to some extent the effect of IL-1 beta on the AA-induced ear oedema.	Indomethacin	0-12	interleukin 1 beta	Mus musculus	160-169
2525134-8	1989	1,25-(OH)2D3 inhibited the production of both extracellular and cell-associated immunoreactive IL1 alpha and IL1 beta.	Calcitriol	0-12	interleukin 1 beta	Mus musculus	109-117
2535251-7	1989	On the other hand, crosslinking studies with [125I]IL-1 beta on D10S cells revealed a novel 46 kD band on gradient SDS-PAGE corresponding to a binding protein of 29 to 30 kD, which is antigenically distinct from the 80 kD IL-1R.	Sodium Dodecyl Sulfate	115-118	interleukin 1 beta	Mus musculus	51-60
2570112-8	1989	Optimal doses of CsA inhibited TPA-induced ODC activity, TGase activity, arachidonic acid release, and interleukin-1 beta (IL-1 beta) mRNA to the same degree (approximately 80%), despite measurement at widely different times (30 min-12 h) required to obtain maximal induction by TPA.	Cyclosporine	17-20	interleukin 1 beta	Mus musculus	103-121
2570112-8	1989	Optimal doses of CsA inhibited TPA-induced ODC activity, TGase activity, arachidonic acid release, and interleukin-1 beta (IL-1 beta) mRNA to the same degree (approximately 80%), despite measurement at widely different times (30 min-12 h) required to obtain maximal induction by TPA.	Cyclosporine	17-20	interleukin 1 beta	Mus musculus	123-132
2786748-3	1989	Interleukin 1 beta infusion also protected against DXN-induced atrophy of thymus and secondary lymphoid organs.	Doxorubicin	51-54	interleukin 1 beta	Mus musculus	0-18
2651547-4	1989	Immunoperoxidase staining for cell-associated TNF alpha, IL-1 alpha, and IL-1 beta demonstrated that PGE2 suppressed TNF, but not IL-1 alpha or -beta expression, supporting the bioassay data.	Dinoprostone	101-105	interleukin 1 beta	Mus musculus	73-82
2613398-3	1989	Lobenzarit, traxanox, mizoribine and cyclosporin A inhibited or tended to inhibit bone resorption stimulated by PTH, LPS, IL-1 beta or TNF-alpha in a dose-dependent manner.	lobenzarit	0-10	interleukin 1 beta	Mus musculus	122-131
2613398-3	1989	Lobenzarit, traxanox, mizoribine and cyclosporin A inhibited or tended to inhibit bone resorption stimulated by PTH, LPS, IL-1 beta or TNF-alpha in a dose-dependent manner.	traxanox	12-20	interleukin 1 beta	Mus musculus	122-131
2613398-3	1989	Lobenzarit, traxanox, mizoribine and cyclosporin A inhibited or tended to inhibit bone resorption stimulated by PTH, LPS, IL-1 beta or TNF-alpha in a dose-dependent manner.	mizoribine	22-32	interleukin 1 beta	Mus musculus	122-131
2613398-3	1989	Lobenzarit, traxanox, mizoribine and cyclosporin A inhibited or tended to inhibit bone resorption stimulated by PTH, LPS, IL-1 beta or TNF-alpha in a dose-dependent manner.	Cyclosporine	37-50	interleukin 1 beta	Mus musculus	122-131
3495595-2	1987	alpha-MSH administration was also capable of inhibiting the capacity of i.v.-administered IL 1 beta to enhance plasma levels of corticosterone and to depress the generation and/or elicitation of contact hypersensitivity responses to skin-reactive chemicals.	Corticosterone	128-142	interleukin 1 beta	Mus musculus	90-99
3141017-2	1988	IL-1(beta) stimulated cell proliferation which increased cell number and caused dose-related stimulation of DNA synthesis, with a maximal effect at a concentration of 12.5 U/ml; suppressed alkaline phosphatase activity and collagen synthesis maximally at 0.5 and 62.5 U/ml, respectively; and increased the amount of free [3H] hydroxyproline in the cultures, but the amount was quite low.	3h] hydroxyproline	322-340	interleukin 1 beta	Mus musculus	0-10
3141017-3	1988	Prostaglandin E2 synthesis was also stimulated dose dependently by the presence of IL-1(beta), with a maximal increase at 2.5 U/ml, at which concentration the prostaglandin E2 level in the medium was 1.61 +/- 0.10 ng/ml.	Dinoprostone	0-16	interleukin 1 beta	Mus musculus	83-93
3141017-3	1988	Prostaglandin E2 synthesis was also stimulated dose dependently by the presence of IL-1(beta), with a maximal increase at 2.5 U/ml, at which concentration the prostaglandin E2 level in the medium was 1.61 +/- 0.10 ng/ml.	Dinoprostone	159-175	interleukin 1 beta	Mus musculus	83-93
2967326-4	1988	rM IL-1 beta was purified to homogeneity and characterized by oligonucleotide and NH2-terminal sequence analysis.	Oligonucleotides	62-77	interleukin 1 beta	Mus musculus	3-12
2967326-5	1988	Purified rM IL-1 beta exhibited biologic activity equivalent to 7.8 x 10(7) units/mg in the murine thymocyte proliferation assay and 9.9 x 10(3) units/mg in the human gingival fibroblast PGE2 production assay, indicative of species specificity.	Dinoprostone	187-191	interleukin 1 beta	Mus musculus	12-21
3260741-4	1988	Inhibition of IL-1 secretion by probucol may contribute to the therapeutic effect of probucol in atherosclerosis since as little as 1 unit of recombinant IL-1 beta was found to induce proliferation of aortic smooth muscle cells.	Probucol	85-93	interleukin 1 beta	Mus musculus	154-163
2937055-6	1986	The fibroblasts possess 4.8 +/- 0.5 X 10(3) IL-1 receptors per cell and bind 125I-labeled IL-1 beta with an affinity of 2.6 +/- 0.5 X 10(9) M-1.	Iodine-125	77-81	interleukin 1 beta	Mus musculus	90-99
3502358-2	1987	Results indicate that both IL-1 alpha and IL-1 beta (1-10 U/ml) are able to stimulate the generation of NK cells from 5-fluorouracil (5-FU) resistant BM progenitors.	Fluorouracil	118-132	interleukin 1 beta	Mus musculus	42-51
3502358-2	1987	Results indicate that both IL-1 alpha and IL-1 beta (1-10 U/ml) are able to stimulate the generation of NK cells from 5-fluorouracil (5-FU) resistant BM progenitors.	Fluorouracil	134-138	interleukin 1 beta	Mus musculus	42-51
3492706-6	1986	Hybridization of P388D1 RNA from cells stimulated with phorbol myristic acetate with a genomic DNA probe shows the existence of a 1.6 Kb murine IL-1 beta mRNA which is absent in the unstimulated cells.	phorbol myristic acetate	55-79	interleukin 1 beta	Mus musculus	144-153
33957261-3	2021	Current results showed that PGG significantly inhibited secretions of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), interleukin-6 (IL-6) and mediator nitric oxide (NO) in LPS-stimulated RAW264.7 cells.	pentagalloylglucose	28-31	interleukin 1 beta	Mus musculus	111-129
34047943-6	2021	Melatonin was found to reduce both paw thickness and the inflammation index in the mouse model, and melatonin also reduced the mRNA levels of interleukin-1 beta (IL-1beta), IL-6 and NLR family pyrin domain containing 3 (NLRP3) inflammasome.	Melatonin	100-109	interleukin 1 beta	Mus musculus	142-160
33882688-7	2021	Sorted thioglycollate-elicited peritoneal macrophages freshly isolated from APOA1Tg; Ldlr-/- mice, which have higher HDL levels than Ldlr-/- controls, showed reduced expression of interferon-inducible genes in response to lipopolysaccharide or interferon-beta, but exacerbated proinflammatory responses to lipopolysaccharide for Tnfa, Cxcl1, Ccl2, and Il1b, phenocopying cells stimulated with HDL in vitro.	Thioglycolates	7-21	interleukin 1 beta	Mus musculus	352-356
33667521-9	2021	Piperine dramatically reduced the serum levels of lipopolysaccharide (LPS), interleukin-1beta (IL-1beta) and Galectin-3 (Gal-3), suppressed the expression of M1-like cytokines (CD11c, IL-1beta and Gal-3) in epididymal adipose tissues and islets.	piperine	0-8	interleukin 1 beta	Mus musculus	76-93
33063357-8	2021	In DSS-treated mice, the disease activity index and expression levels of interleukin-1beta and tumor necrosis factor-alpha were enhanced in the SY group, concluding that SY exacerbated DSS-induced intestinal inflammation.	Dextran Sulfate	3-6	interleukin 1 beta	Mus musculus	73-90
33211285-6	2021	In addition, Ramelteon displayed a robust anti-inflammatory capacity against isoflurane-induced insults and inflammation by reducing the generation of interleukin-1beta (IL-1beta), transforming growth factor-beta (TGF-beta), monocyte chemotactic protein 1 (MCP-1), stromal cell-derived factor-1 (SDF-1), matrix metalloproteinase-2 (MMP-2), and MMP-9.	ramelteon	13-22	interleukin 1 beta	Mus musculus	151-168
34038497-7	2021	In addition, S-equol administration significantly decreased the levels of pro-inflammatory cytokines (tumor necrosis factor, interleukin-6, interleukin-10, interleukin-1beta), increased the levels of 5-hydroxytryptamine and norepinephrine, and normalized the release of tryptophan and kynurenine in the hippocampi of lipopolysaccharide-treated mice.	Equol	13-20	interleukin 1 beta	Mus musculus	156-173
34052309-6	2021	Mechanistically, glibenclamide treatment blocked NLRP3 inflammasome activation evidenced by reduced expressions of NLRP3, activated caspase-1 and mature interleukin-1beta in glibenclamide co-treated mice compared with those in paraquat and maneb group mice.	Glyburide	17-30	interleukin 1 beta	Mus musculus	153-170
34052309-6	2021	Mechanistically, glibenclamide treatment blocked NLRP3 inflammasome activation evidenced by reduced expressions of NLRP3, activated caspase-1 and mature interleukin-1beta in glibenclamide co-treated mice compared with those in paraquat and maneb group mice.	Glyburide	174-187	interleukin 1 beta	Mus musculus	153-170
34023353-8	2021	DMF also decreased pro-inflammatory cytokine expression (Tnf) 3 days after MI, and decreased inflammatory markers in macrophages isolated from the infarcted heart (Hif1a, Il1b).	Dimethyl Fumarate	0-3	interleukin 1 beta	Mus musculus	171-175
33993695-7	2021	EGCG markedly induced the production of cytokines and chemokines in macrophages and mouse peritoneal lavage, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), IL-6, CXC chemokine ligands 1 and 2 (CXCL1 and 2), and monocyte chemotactic protein-1 (MCP-1).	epigallocatechin gallate	0-4	interleukin 1 beta	Mus musculus	160-178
34017331-4	2021	Therefore, the mechanism of SEO-induced interleukin-1beta (IL-1beta) secretion in mouse neutrophils was investigated in this study.	seo	28-31	interleukin 1 beta	Mus musculus	40-57
33998633-9	2021	HT administration significantly suppressed microglia activation and inhibited the expression of tumor necrosis factor alpha and interleukin 1 beta in the hippocampus versus the untreated group.	3,4-dihydroxyphenylethanol	0-2	interleukin 1 beta	Mus musculus	128-146
33677656-10	2021	In the biochemical analysis, reserpine treatment upregulated the monoamine oxidase-A (MAO-A) activity and level of glutamate, tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and thiobarbituric acid reactive substances (TBARS).	Reserpine	29-38	interleukin 1 beta	Mus musculus	167-184
33656514-3	2021	Here, we show that vincristine-induced peripheral neuropathy is driven by activation of the NLRP3 inflammasome and subsequent release of interleukin-1beta from macrophages, with mechanical allodynia and gait disturbances significantly reduced in knockout mice lacking NLRP3 signaling pathway components, or after treatment with the NLRP3 inhibitor MCC950.	Vincristine	19-30	interleukin 1 beta	Mus musculus	137-154
33662500-8	2021	KRG treatment prevented MPTP-induced behavioral impairment, dopaminergic neuronal death, activation of microglia and astrocytes in the nigrostriatal pathway, disruption of tight junction and the increase in alpha-synuclein, interleukin-1beta and tumor necrosis factor-alpha expression in the colon.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	24-28	interleukin 1 beta	Mus musculus	224-241
33911050-6	2021	In addition, MPTP/LPS enhanced interleukin-1beta (IL-1beta) expression and processing via nod-like receptor protein 3 (NLRP3) inflammasome activation in the SN region of mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	13-17	interleukin 1 beta	Mus musculus	31-48
32176932-8	2021	RESULTS: The results demonstrated that the effect of HFD on inflammatory cytokines in mice with apoE-/- background was reversed by celastrol administration, and celastrol treatment inhibited the NOD-like receptor family, pyrin domain containing 3 (NLRP3)/caspase-1/interleukin-1beta signaling cascades in peripheral blood mononuclear cells from HFD-fed apoE-/- mice.	celastrol	161-170	interleukin 1 beta	Mus musculus	265-282
31198052-5	2021	Furthermore, the increase of pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6 and IL-18 levels were significantly suppressed by isostrictiniin pretreatment compared with model group (P < 0.05).	isostrictiniin	132-146	interleukin 1 beta	Mus musculus	67-75
33349609-8	2021	SC-E3 also reduced serum levels of tumor necrosis factor-alpha, interleukin-1beta, aspartate aminotransferase and alanine aminotransferase.	sc-e3	0-5	interleukin 1 beta	Mus musculus	64-81
33892379-4	2021	Here, we found that BA significantly attenuates the activation of caspase-1 and the subsequent secretion of the interleukin-1beta (IL-1beta) in mouse macrophages and human THP-1 cells, showing the inhibitory effect of BA on the NLRP3 inflammasome activation.	brevilin A	20-22	interleukin 1 beta	Mus musculus	112-129
33749522-9	2021	Rifampicin suppressed the release of pro-inflammatory mediators, including tumor necrosis factor-alpha, interleukin-1beta, and prostaglandin E2 in the serum and nitric oxide (NO) in brain tissue, and cyclooxygenase-2 and inducible nitric oxide synthase levels.	Rifampin	0-10	interleukin 1 beta	Mus musculus	104-121
33827248-10	2021	Moreover, heme increased the expression of HO-1 (heme oxygenase-1), ferritin, p62, and superoxide dismutase 2, and activated the MAPK signaling pathway promoting pro-IL (interleukin)-1beta production and its cleavage to the active form.	Heme	10-14	interleukin 1 beta	Mus musculus	162-188
34012471-4	2021	Our data indicated that Mog significantly inhibited the LPS-induced production of proinflammatory factors, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-18, IL-6, cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and high mobility group box 1 (HMGB1) in BV-2 cells.	mogroside V	24-27	interleukin 1 beta	Mus musculus	156-173
33909081-8	2021	Additionally, Xanthohumol increased superoxide dismutase level and reduced Interleukin-6 and Interleukin-1beta levels both in serum and hippocampus.	xanthohumol	14-25	interleukin 1 beta	Mus musculus	93-110
33906960-5	2021	During NEC, compared with wild-type mice treated with vehicle, littermates treated with an AhR proligand, indole-3-carbinol, had reduced expression of Il1b and Marco, a scavenger receptor that mediates dendritic cell activation and the recognition and clearance of bacterial pathogens by macrophages.	indole-3-carbinol	106-123	interleukin 1 beta	Mus musculus	151-155
33919055-0	2021	Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages.	Auranofin	0-9	interleukin 1 beta	Mus musculus	45-63
33876419-1	2021	BACKGROUND: beta-Ecdysone has been reported to perform a protective effect to prevent interleukin 1beta (IL-1beta)-induced apoptosis and inflammatory response in chondrocytes.	Ecdysterone	12-25	interleukin 1 beta	Mus musculus	86-103
33787243-4	2021	Western blot and quantitative polymerase chain reaction analyses indicated that 4DT exerted more potent suppressive activity on the over-expression of interleukin-1beta, inducible nitric oxide synthase, and cyclooxygenase-2 than TAN.	4DT	80-83	interleukin 1 beta	Mus musculus	151-168
33878160-9	2021	Sulindac treatment also resulted in a marked change in the immune profile of L2-IL-1B mice.	Sulindac	0-8	interleukin 1 beta	Mus musculus	80-85
33892379-4	2021	Here, we found that BA significantly attenuates the activation of caspase-1 and the subsequent secretion of the interleukin-1beta (IL-1beta) in mouse macrophages and human THP-1 cells, showing the inhibitory effect of BA on the NLRP3 inflammasome activation.	brevilin A	218-220	interleukin 1 beta	Mus musculus	112-129
33870507-4	2021	In this study, we investigated the therapeutic effects of nepetin on interleukin-1beta (IL-1beta)-induced inflammation in mice chondrocyte and OA model.	eupafolin	58-65	interleukin 1 beta	Mus musculus	69-86
33878544-5	2021	In vitro cell experiments, the inflammatory response in chondrocytes is mediated via interleukin-1beta (IL-1beta), which led to abnormal secretion of pro-inflammatory factors, such as prostaglandin E2 (PGE2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), cyclooxygenase-2 (COX-2), nitric oxide (NO) and inducible nitric oxide synthase (iNOS).	Dinoprostone	184-200	interleukin 1 beta	Mus musculus	85-102
33878544-5	2021	In vitro cell experiments, the inflammatory response in chondrocytes is mediated via interleukin-1beta (IL-1beta), which led to abnormal secretion of pro-inflammatory factors, such as prostaglandin E2 (PGE2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), cyclooxygenase-2 (COX-2), nitric oxide (NO) and inducible nitric oxide synthase (iNOS).	Dinoprostone	202-206	interleukin 1 beta	Mus musculus	85-102
33878544-5	2021	In vitro cell experiments, the inflammatory response in chondrocytes is mediated via interleukin-1beta (IL-1beta), which led to abnormal secretion of pro-inflammatory factors, such as prostaglandin E2 (PGE2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), cyclooxygenase-2 (COX-2), nitric oxide (NO) and inducible nitric oxide synthase (iNOS).	Nitric Oxide	298-310	interleukin 1 beta	Mus musculus	85-102
33732302-7	2021	Furthermore, butyrate decreased the levels of pro-inflammatory cytokines interleukin-1beta, tumour necrosis factor-alpha and leukotriene B4, which helped combat inflammatory responses.	Butyrates	13-21	interleukin 1 beta	Mus musculus	73-90
33935701-11	2021	Moreover, EEFE significantly suppressed the inflammatory cytokines interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha), and expression of ionized calcium-binding adaptor molecule 1 (Iba-1), a marker of microglial activation, in brain tissues of Abeta-injected mice, suggesting anti-neuroinflammatory effects.	eefe	10-14	interleukin 1 beta	Mus musculus	67-84
33987329-5	2021	Lycopene inhibited F4/80+ macrophage and Ly6G+ neutrophil accumulation, which further decreased the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin 6 (IL-6).	Lycopene	0-8	interleukin 1 beta	Mus musculus	151-168
33370589-10	2021	The increased brain contents of malondialdehyde, TNF-alpha, interleukin-1beta, and decreased antioxidant (GSH and SOD) status were attenuated by Naringenin.	naringenin	145-155	interleukin 1 beta	Mus musculus	60-77
33929904-9	2021	Il1a and Il1b induction with LPS or LPS+ATP challenge was diminished.	Adenosine Triphosphate	40-43	interleukin 1 beta	Mus musculus	9-13
33006074-8	2021	Pte also inhibits LPS/D-Gal-induced secretion of pro-inflammatory cytokine tumor necrosis factor-a (TNF-alpha), interleukin 6 (IL-6), and interleukin 1beta (IL-1beta) in liver tissues.	Galactose	22-27	interleukin 1 beta	Mus musculus	138-155
33616187-8	2021	Investigation of early inflammatory events showed that captopril significantly attenuated macrophage accumulation and decreased the synthesis of radiation-induced interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) pro-inflammatory cytokines in the lungs of irradiated mice.	Captopril	55-64	interleukin 1 beta	Mus musculus	163-180
33333238-5	2021	Similarly, the levels of myeloperoxidase (MPO) and interleukin-1beta (IL-1beta) were lowered by Tollip overexpression in PQ-administrated mice.	Paraquat	121-123	interleukin 1 beta	Mus musculus	51-68
33740180-7	2022	Concurrently, CuSO4 caused inflammation by increasing the mRNA levels of interleukin-1beta (IL-1beta), IL-2, IL-4, IL-6, IL-12, tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma).	Copper Sulfate	14-19	interleukin 1 beta	Mus musculus	73-90
33493484-10	2021	In animal experiments, rosuvastatin significantly improved the cardiac function of post-myocardial infarction mice and prevented the development of HF after myocardial infarction by inhibiting IL-1Beta expression.	Rosuvastatin Calcium	23-35	interleukin 1 beta	Mus musculus	193-201
33706700-17	2021	Interleukin-1beta (IL-1beta) mRNA expression was significantly increased only in 41-week-old arsenite-F2 mice.	arsenite	93-101	interleukin 1 beta	Mus musculus	0-17
33421258-10	2021	Also, the enzyme-linked immunosorbent assay results indicate that trelagliptin-treated mice displayed anti-inflammatory properties by reducing the levels of interleukin 1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha.	trelagliptin	66-78	interleukin 1 beta	Mus musculus	157-174
33650604-3	2021	QTW and QTE significantly inhibited the alanine aminotransaminase, aspartate aminotransaminase, tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta levels in the serum.	[(2~{R},3~{S},4~{S},5~{R})-3,4-bis(oxidanyl)-5-[3-[4-[(~{E})-phenylcarbonyliminomethyl]-1,2,3-triazol-1-yl]propyl]oxan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-4-methyl-pentanoyl]sulfamate	0-3	interleukin 1 beta	Mus musculus	144-161
33650604-3	2021	QTW and QTE significantly inhibited the alanine aminotransaminase, aspartate aminotransaminase, tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta levels in the serum.	cyclohexylmethanol	8-11	interleukin 1 beta	Mus musculus	144-161
33497687-9	2021	Arsenic increased proinflammatory cytokine (tumor necrosis factor-alpha and interleukin-1beta) levels, enhanced caspase-3 and Bax expression, and reduced Bcl-2 expression.	Arsenic	0-7	interleukin 1 beta	Mus musculus	76-93
33119198-8	2021	Moreover, dendrobine reduced the secretion of inflammatory cytokines by T-helper 17 (Th17) cells, including interleukin-1beta, interleukin-6, tumour necrosis factor-alpha and interleukin-17.	dendrobine	10-20	interleukin 1 beta	Mus musculus	108-125
33707964-9	2021	Results: Punicalin significantly blocked the production of endogenous ROS, reduced LPS/ATP-induced activation of NLRP3, caspase 1, ASC and GSDMD-N, IL-1b and IL-18 protein levels.	punicalin	9-18	interleukin 1 beta	Mus musculus	148-153
33422760-5	2021	The results demonstrated that psoralidin activated the inflammasomes followed by secreting caspase-1 and interleukin 1beta (IL-1beta) in a dose-dependent manner.	psoralidin	30-40	interleukin 1 beta	Mus musculus	105-122
33259938-4	2021	Our results showed that in wide type mice, renal function loss, tissue injury and cell death induced by cisplatin were alleviated by pretreatment of high-dose paricalcitol(a VDR agonist) accompanied with up-regulated VDR and decreased expression of NLRP3, GSDMD-N, Cleaved-Caspase-1 and mature Interleukin- 1beta (features of pyroptosis).	Cisplatin	104-113	interleukin 1 beta	Mus musculus	294-312
33239236-9	2021	Moreover, RESV administration significantly ameliorated BPA-aggravated NOD-like receptor pyrin domain 3 and caspase 1 activation and interleukin-1beta production, which were abolished by NBS1 knockdown.	Resveratrol	10-14	interleukin 1 beta	Mus musculus	133-150
33239236-9	2021	Moreover, RESV administration significantly ameliorated BPA-aggravated NOD-like receptor pyrin domain 3 and caspase 1 activation and interleukin-1beta production, which were abolished by NBS1 knockdown.	bisphenol A	56-59	interleukin 1 beta	Mus musculus	133-150
32918847-0	2021	NLRP3 inflammasome-derived interleukin-1beta attenuates stress-induced gastric injury via the COX-2/PGE2 axis.	Dinoprostone	100-104	interleukin 1 beta	Mus musculus	27-44
33728026-5	2021	Moreover, oxyberberine inhibited inflammation, as indicated by the changes of neutrophil accumulation and production of proinflammatory cytokines including tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), and IL-6 in both the lung and bronchoalveolar lavage fluid (BALF) in ALI mice.	8-oxoberberine	10-22	interleukin 1 beta	Mus musculus	197-214
33639199-2	2021	For instance, cocaine can directly bind to surface receptors on microglia and trigger their release of interleukin-1beta, which promotes addictive behaviors; however, cocaine also indirectly stimulates microglia by elevating dopamine, which causes microglia to impair long-lasting neuronal changes related to cocaine use.	Cocaine	14-21	interleukin 1 beta	Mus musculus	103-120
33639199-2	2021	For instance, cocaine can directly bind to surface receptors on microglia and trigger their release of interleukin-1beta, which promotes addictive behaviors; however, cocaine also indirectly stimulates microglia by elevating dopamine, which causes microglia to impair long-lasting neuronal changes related to cocaine use.	Cocaine	167-174	interleukin 1 beta	Mus musculus	103-120
33639199-2	2021	For instance, cocaine can directly bind to surface receptors on microglia and trigger their release of interleukin-1beta, which promotes addictive behaviors; however, cocaine also indirectly stimulates microglia by elevating dopamine, which causes microglia to impair long-lasting neuronal changes related to cocaine use.	Cocaine	167-174	interleukin 1 beta	Mus musculus	103-120
33564842-2	2021	The Omega class glutathione transferase GSTO1-1 regulates the release of the pro-inflammatory cytokines interleukin 1beta (IL-1beta) and interleukin 18 (IL-18) by deglutathionylating NEK7 in the NLRP3 inflammasome.	Glutathione	16-27	interleukin 1 beta	Mus musculus	104-121
33259938-4	2021	Our results showed that in wide type mice, renal function loss, tissue injury and cell death induced by cisplatin were alleviated by pretreatment of high-dose paricalcitol(a VDR agonist) accompanied with up-regulated VDR and decreased expression of NLRP3, GSDMD-N, Cleaved-Caspase-1 and mature Interleukin- 1beta (features of pyroptosis).	paricalcitol	159-171	interleukin 1 beta	Mus musculus	294-312
32750462-14	2021	The ethanol extracts of GR-SC65 exerted a stronger anti-inflammatory activity than GR by inhibiting pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) in LPS-induced RAW264.7 macrophages.	Ethanol	4-11	interleukin 1 beta	Mus musculus	203-220
33509279-7	2021	DSS led to edema, epithelial layer disruption, inflammatory cell infiltration, and cytokine induction (tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta) in the colon tissues.	Dextran Sulfate	0-3	interleukin 1 beta	Mus musculus	151-168
33501367-11	2020	EBT occurred in DF508 mice (mice with the F508del CFTR gene mutation), accompanied by augmented tumor necrosis factor-alpha, interleukin-1beta and interleukin-8 levels in the ileum compared to wildtype mice.	ebt	0-3	interleukin 1 beta	Mus musculus	125-142
33510843-9	2021	Adenine induced a significant increase in systolic blood pressure and the concentrations of troponin I, tumor necrosis factor-alpha, and interleukin-1beta in heart homogenates.	Adenine	0-7	interleukin 1 beta	Mus musculus	137-154
33462188-9	2021	Furthermore, the activation of NLRP3 inflammasome was noted in primary microglia treated with CuCl2, accompanied by the increased levels of cleaved caspase-1, ASC, and interleukin-1beta.	cupric chloride	94-99	interleukin 1 beta	Mus musculus	168-185
33477467-6	2021	The results showed that under the action of adenosine-triphosphate (ATP), rTSST-1 significantly induced interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) production in mouse macrophages and the production was dose-dependent.	Adenosine	44-53	interleukin 1 beta	Mus musculus	104-121
33477467-6	2021	The results showed that under the action of adenosine-triphosphate (ATP), rTSST-1 significantly induced interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) production in mouse macrophages and the production was dose-dependent.	Adenosine Triphosphate	68-71	interleukin 1 beta	Mus musculus	104-121
33423680-10	2021	RESULTS: Following ethanol treatment, the brains of hHSPB1-overexpressing mice showed a significantly higher mRNA level of pro-inflammatory cytokines (Tnf, Il1b), microglia (Cd68, Arg1), and astrocyte (Gfap) markers compared to wild-type brains.	Ethanol	19-26	interleukin 1 beta	Mus musculus	156-160
32721223-3	2021	TNF-alpha, IL-1b, IL-6 and IL-8 that leads to a cascade that negatively impacts methionine-metabolism and homocysteine cycling.	Methionine	80-90	interleukin 1 beta	Mus musculus	11-16
33197761-9	2021	Mechanistically, we observed that NXT inhibited neuron atrophy and apoptosis by downregulating inflammatory cytokines, interleukin 1beta (IL-1beta), IL-6 and tumor necrosis factor alpha (TNF-alpha), and inflammation mediators, nuclear factor kappaB (NF-kappaB) and toll-like receptor 4 (TLR4) in the brain.	nxt	34-37	interleukin 1 beta	Mus musculus	119-136
32971182-6	2021	The idea of using MPP+ after priming mouse microglia with LPS was to disrupt mitochondria and release reactive oxygen species, which act as Signal 2 in augmenting NLRP3 assembly, thereby releasing potent inflammatory mediators such as active interleukin-1 beta (IL-1beta) and IL-18.	Oxygen	111-117	interleukin 1 beta	Mus musculus	242-260
33078829-0	2021	Microcystin-LR induces NLRP3 inflammasome activation via FOXO1 phosphorylation, resulting in interleukin-1beta secretion and pyroptosis in hepatocytes.	cyanoginosin LR	0-14	interleukin 1 beta	Mus musculus	93-110
32721223-3	2021	TNF-alpha, IL-1b, IL-6 and IL-8 that leads to a cascade that negatively impacts methionine-metabolism and homocysteine cycling.	Homocysteine	106-118	interleukin 1 beta	Mus musculus	11-16
31511642-1	2021	Monosodium urate (MSU) crystals activate inflammatory pathways that overlap with interleukin-1beta (IL-1beta) signaling.	Uric Acid	0-16	interleukin 1 beta	Mus musculus	81-98
33307514-6	2021	Concomitant with enlarged colonic patches, the cultured colon of infected mice treated with berberine secreted significantly higher levels of interleukin-1beta (IL-1beta), IL-6, TNF-alpha, and CCL-2, while NLRP3 inhibitor MMC950 or knockout of NLRP3 gene abrogated berberine-induced hypertrophy of colonic patches, suggesting the involvement of the NLRP3 signaling pathway in this process.	Berberine	92-101	interleukin 1 beta	Mus musculus	142-159
31846964-0	2021	NOD-Like Receptor Family Pyrin Domain-Containing 3 Inflammasome Activation Exacerbates 5-Fluorouracil-Induced Small Intestinal Mucositis via Interleukin-1beta Activation.	MRT67307	25-30	interleukin 1 beta	Mus musculus	141-158
31846964-0	2021	NOD-Like Receptor Family Pyrin Domain-Containing 3 Inflammasome Activation Exacerbates 5-Fluorouracil-Induced Small Intestinal Mucositis via Interleukin-1beta Activation.	Fluorouracil	87-101	interleukin 1 beta	Mus musculus	141-158
31846964-13	2021	CONCLUSIONS: NLRP3 inflammasome activation may exacerbate 5-FU-induced small intestinal mucositis via IL-1beta maturation.	Fluorouracil	58-62	interleukin 1 beta	Mus musculus	102-110
32347046-12	2021	Furthermore, neferine significantly decreased serum levels of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and IL-6 and increased serum levels of anti-inflammatory cytokine IL-10.	neferine	13-21	interleukin 1 beta	Mus musculus	140-158
32891972-8	2021	Furthermore, Western blot analysis indicated that La(NO3)3 significantly down-regulated inflammation-mediated proteins including phosphorylated p38 mitogen-activated protein kinases (p-p38 MAPK), monocyte chemo-attractant protein, intercellular adhesion molecule-1, nuclear factor-kappa B p65 (NF-kappaB p65), tumor necrosis factor-alpha, interleukin-6 and interleukin-1beta, whereas up-regulated the inhibitor of NF-kappaB protein.	la(no3)3	50-58	interleukin 1 beta	Mus musculus	357-374
33085775-10	2021	Moreover, after using the autophagy activator rapamycin, the expression of the inflammatory cytokines interleukin-1beta was decreased and the pain symptoms were alleviated.	Sirolimus	46-55	interleukin 1 beta	Mus musculus	102-119
33523018-10	2021	Gly(2)-GLP-2 furthermore reduced the inflammation response as seen in lower microglia activation, and decreased NLRP3 and interleukin-1beta pro-inflammatory cytokine expression levels.	Glycine	0-3	interleukin 1 beta	Mus musculus	122-139
32780228-0	2021	Effect of nifedipine, a calcium channel blocker, on the generation of nitric oxide and interleukin-1beta by murine macrophages activated by lipopolysaccharide from Prevotella intermedia.	Nifedipine	10-20	interleukin 1 beta	Mus musculus	87-104
32996187-5	2021	Endocannabinoids and related mediators were assessed by LC-MS. DNBS increased colon weight/colon length ratio, myeloperoxidase activity, interleukin-1beta, and intestinal permeability.	2,4-dinitrobenzenesulfonic acid	63-67	interleukin 1 beta	Mus musculus	137-154
33381582-9	2020	Coenzyme Q10 significantly inhibited the elevation of sequestosome-1, interleukin-1beta, oligomerization domain-like receptor 3 and nucleotide-binding, interleukin-6, and tumor necrosis factor-alpha expression levels; coenzyme Q10 also increased beclin 1 levels.	coenzyme Q10	0-12	interleukin 1 beta	Mus musculus	70-87
33488936-5	2020	Moreover, dioscin also can reduce the production of proinflammatory factors such as interleukin-1 beta (IL-1beta) and inhibit the activation of NLRP3 inflammasome in LPS-induced mice mastitis.	dioscin	10-17	interleukin 1 beta	Mus musculus	84-102
33355143-5	2020	In mouse islets, high-fat diet triggered the IL1B expression in beta cells before macrophage recruitment in vivo, and RIPK3 inhibition suppressed palmitate-induced beta cell dysfunction and Il1b expression in vitro.	Palmitates	146-155	interleukin 1 beta	Mus musculus	190-194
33214151-3	2020	We now show that RBP4 primes the NLRP3 inflammasome for interleukin-1beta (IL1beta) release, in a glucose-dependent manner, through the TLR4/MD2 receptor complex and TLR2.	Glucose	98-105	interleukin 1 beta	Mus musculus	56-73
33165201-0	2020	Nicotine induces P2X4 receptor, interleukin-1 beta, and brain-derived neurotrophic factor expression in BV2 microglia cells.	Nicotine	0-8	interleukin 1 beta	Mus musculus	32-50
33311467-7	2020	Such alterations result in the suppression of succinate-mediated HIF-1alpha activation, imposing a consequent reduction of LPS-induced Il1b expression.	Succinic Acid	46-55	interleukin 1 beta	Mus musculus	135-139
33291425-8	2020	We demonstrate here that EPS suppressed proinflammatory mediators, such as cyclooxygenase-2, interleukin-6, tumor necrosis factor-alpha, and interleukin-1beta, and downregulated the expression of an inducible nitric oxide synthase known to lead to oxidative stress.	eps	25-28	interleukin 1 beta	Mus musculus	141-158
33362373-14	2020	In addition, nimbolide treatment to HCC mice ameliorated hepatic inflammation by reducing NF-kappaB, interleukin 1 beta and TNF-alpha expression (P < 0.05, respectively) and abrogated oxidative stress by attenuating 4-hydroxynonenal expression (P < 0.01).	nimbolide	13-22	interleukin 1 beta	Mus musculus	101-119
33035507-4	2020	It also reduced mRNA expression of inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha, interleukin-1beta (IL-1 beta), and IL-6, indicating that 3-DA has anti-inflammatory properties in murine and human macrophages.	3-da	172-176	interleukin 1 beta	Mus musculus	115-132
33183976-7	2020	Treatment with taraxasterol attenuated the following in a dose-dependent manner: tubular damage; infiltration of F4/80-positive macrophages; renal interstitial fibrosis; myeloperoxidase (MPO) activity; and expression of the inflammatory cytokines tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and monocyte chemoattractant protein-1 (MCP-1).	taraxasterol	15-27	interleukin 1 beta	Mus musculus	289-306
33174016-7	2020	HBL and HBB increased the expression of heme oxygenase-1 (HO-1) protein by inducing the nuclear accumulation of nuclear factor erythroid 2-related factor 2 (Nrf2) through the activation of the reactive oxygen species (ROS)/p38 pathway; the reduction in inducible nitric oxide synthase (iNOS) and interleukin-1beta (IL-1beta) expression by HBL and HBB was inhibited by HO-1 knockdown.	Reactive Oxygen Species	193-216	interleukin 1 beta	Mus musculus	296-313
33174016-7	2020	HBL and HBB increased the expression of heme oxygenase-1 (HO-1) protein by inducing the nuclear accumulation of nuclear factor erythroid 2-related factor 2 (Nrf2) through the activation of the reactive oxygen species (ROS)/p38 pathway; the reduction in inducible nitric oxide synthase (iNOS) and interleukin-1beta (IL-1beta) expression by HBL and HBB was inhibited by HO-1 knockdown.	Reactive Oxygen Species	218-221	interleukin 1 beta	Mus musculus	296-313
33007732-10	2020	Withaferin A could significantly reverse the increases in the protein levels of pro-fibrotic factors (fibronectin, transforming growth factor-beta, and alpha-smooth muscle actin), inflammatory signaling molecules (phosphorylated nuclear factor-kappaB-p65, interleukin-1beta, and cyclooxygenase-2), and cleaved caspase-3, apoptosis, and infiltration of neutrophils in the UUO kidneys.	withaferin A	0-12	interleukin 1 beta	Mus musculus	256-273
31774487-5	2020	We showed that inflammasomes were activated in the PAH mice model and that melatonin attenuated IL-1beta secretion.	Melatonin	75-84	interleukin 1 beta	Mus musculus	96-104
33010263-6	2020	Mechanistically, the anxiolytic effects of resveratrol were accompanied by a marked decrease in YAP, interleukin-1beta and ionized calcium binding adaptor molecule 1 (Iba-1) while a significant increase in autophagic protein expression in the hippocampus.	Resveratrol	43-54	interleukin 1 beta	Mus musculus	101-118
33010263-9	2020	Finally, rapamycin-mediated promotion of autophagy attenuated LPS-induced anxiety-like behavior and decreased interleukin-1beta and Iba-1 expression in the hippocampus.	Sirolimus	9-18	interleukin 1 beta	Mus musculus	110-127
33240677-7	2020	Minocycline reduced LPS-induced Il1b and Tnf, but not Nos2, mRNA expression.	Minocycline	0-11	interleukin 1 beta	Mus musculus	32-36
32561283-6	2020	Further mechanistic studies indicated that the 5-Fu + SATP group showed a decrease in hepatotoxicity caused by 5-Fu via a reduction in the levels of interleukin-1beta (IL-1beta), an increase in the expression of Bcl-2 and decreases in the expression of p-p38, p-JNK and Bax.	Fluorouracil	47-51	interleukin 1 beta	Mus musculus	149-166
32561283-6	2020	Further mechanistic studies indicated that the 5-Fu + SATP group showed a decrease in hepatotoxicity caused by 5-Fu via a reduction in the levels of interleukin-1beta (IL-1beta), an increase in the expression of Bcl-2 and decreases in the expression of p-p38, p-JNK and Bax.	satp	54-58	interleukin 1 beta	Mus musculus	149-166
32561283-6	2020	Further mechanistic studies indicated that the 5-Fu + SATP group showed a decrease in hepatotoxicity caused by 5-Fu via a reduction in the levels of interleukin-1beta (IL-1beta), an increase in the expression of Bcl-2 and decreases in the expression of p-p38, p-JNK and Bax.	Fluorouracil	111-115	interleukin 1 beta	Mus musculus	149-166
33244198-9	2020	Compared with PSGL-1 +/+ mice, PSGL-1 -/- AP mice induced by caerulein exhibited lower serum amylase, less Interleukin-1beta (IL-1beta) and Interleukin-6 (IL-6) expression, less neutrophil and macrophage infiltration, and reduced peripheral neutrophil and monocyte accounts.	Ceruletide	61-70	interleukin 1 beta	Mus musculus	107-124
33151664-5	2020	PFOA exposure also caused inflammation in gut and brain by increasing lipopolysaccharide, tumor necrosis factor-alpha, interleukin-1 beta, and cyclooxygenase-2 and decreasing interleukin-10.	perfluorooctanoic acid	0-4	interleukin 1 beta	Mus musculus	119-137
33244197-16	2020	Quantitative reverse transcription PCR results showed that the expression of the pyroptosis-related genes caspase-1, NLRP3, GSDMD and interleukin-1beta (IL-1beta) in the CCl4 group was higher than that in the control group, while there was no significant change in NLRP3 and caspase-1 expression in the DHM group compared with that in the vehicle group, and the expression of GSDMD and IL-1beta was decreased.	Carbon Tetrachloride	170-174	interleukin 1 beta	Mus musculus	134-151
33313269-14	2020	Moreover, aspirin reduced the levels of inflammatory factors interleukin-6, interleukin-1beta and tumor necrosis factor-alpha and decreased the activation of STAT3 signaling pathway.	Aspirin	10-17	interleukin 1 beta	Mus musculus	76-93
32846198-7	2020	Furthermore, ECH administration alleviated MPTP-triggered microglial activation, thus downregulated the expression and activation of NLRP3 inflammasomes in mice SN, along with the involved proteins including Caspase (CASP)-1 and interleukin-1beta (IL-1beta).	echinacoside	13-16	interleukin 1 beta	Mus musculus	229-246
32991863-5	2020	In addition, PB4 may mainly act on NF-kappaB signaling pathway to reduce the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) in the kidney after CP exposure, thus exerting anti-inflammatory activity.	MMP-13 Inhibitor	13-16	interleukin 1 beta	Mus musculus	128-146
32870322-6	2020	We further found that metformin significantly suppressed NLRP3 inflammasome activation, subsequent caspase-1 cleavage, and interleukin-1beta secretion in both peripheral macrophages and central hippocampus.	Metformin	22-31	interleukin 1 beta	Mus musculus	123-140
31805776-4	2020	Acetylshikonin could attenuate smoke-induced lung pathological changes, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and monocyte chemoattractant protein 1 (MCP-1) productions, and tissue damages caused by oxidative stress.	acetylshikonin	0-14	interleukin 1 beta	Mus musculus	135-152
32805417-10	2020	The treatment of murine macrophages with rHaCRT induced the expression of immune genes, such as tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), inducible nitric oxide synthase (iNOS), and interleukin-1beta (IL-1beta).	rhacrt	41-47	interleukin 1 beta	Mus musculus	203-220
31805776-4	2020	Acetylshikonin could attenuate smoke-induced lung pathological changes, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and monocyte chemoattractant protein 1 (MCP-1) productions, and tissue damages caused by oxidative stress.	acetylshikonin	0-14	interleukin 1 beta	Mus musculus	154-162
32801029-6	2020	RESULTS: Ethanol increased mRNA expression of interleukin (Il)-6, Il-1b, and tumor necrosis factor alpha with a concomitant increase in nuclear translocation of nuclear factor kappaB, which was abolished by ASTX.	Ethanol	9-16	interleukin 1 beta	Mus musculus	66-71
32965793-6	2020	In vitro, Lico A could reduce the expression of NLRP3, apoptosis-associated speck-like protein (ASC), Gasdermin D (GSDMD), caspase-1, interleukin-1beta (IL-1beta) and IL-18, which indicated that Lico A attenuates LPS-induced chondrocytes pyroptosis.	licochalcone A	10-16	interleukin 1 beta	Mus musculus	134-151
33003981-7	2020	Remarkably, leptin infusion markedly improved endothelial function and significantly reduced vascular NADPH oxidase 1, interleukin-1beta, GATA3, F4/80, and CCR5 levels in ritonavir-treated animals.	Ritonavir	171-180	interleukin 1 beta	Mus musculus	119-136
32519758-7	2020	NaAsO2 exposure was associated with marked increases in renal inflammatory marker (interleukin-1beta and tumor necrosis factor-alpha) and apoptosis indicators including Bax and caspase-3 levels contaminant with a marked decrease in Bcl-2, an anti-apoptotic protein, in the NaAsO2- treated group compared with the control group.	sodium arsenite	0-6	interleukin 1 beta	Mus musculus	83-100
32807758-5	2020	In addition, treatment with PZRAS extract reduced the release of pro-inflammatory cytokines, such as interleukin-1beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha).	pzras extract	28-41	interleukin 1 beta	Mus musculus	101-118
33195691-6	2020	Acacetin inhibited the interleukin-1beta- (IL-1beta-) induced expression of MMP-1, MMP-3, and MMP-13in chondrocytes by blocking nuclear factor-kappaB (NF-kappaB) signaling pathways.	acacetin	0-8	interleukin 1 beta	Mus musculus	23-40
33003981-5	2020	Moreover, ritonavir increased vascular NADPH oxidase 1, aortic H2O2 levels as well as interleukin-1beta, GATA3 (GATA binding protein 3), the macrophage marker (F4/80), and C-C chemokine receptor type 5 (CCR5) expression.	Ritonavir	10-19	interleukin 1 beta	Mus musculus	86-103
32573860-3	2020	Our results revealed that prophylactic administration of THC (40 mg/kg) for 3 days significantly alleviated the increase in brain water content (BWC), interleukin-1beta (IL-1beta) and TNF-alpha levels caused by acute hypobaric hypoxia (AHH).	tetrahydrocurcumin	57-60	interleukin 1 beta	Mus musculus	151-168
33114200-6	2020	Surprisingly, it was found that SM significantly enhanced LPS-induced expression of the pro-inflammatory cytokines interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) in RAW264.7 cells via activation of the c-Jun/Toll-like receptor 4 (TLR4) signaling axis.	Samarium	32-34	interleukin 1 beta	Mus musculus	183-200
33092620-7	2020	Mechanistically, at the level of the spinal cord, naloxone-precipitated withdrawal was associated with increased glial activity and formation of the potent inflammatory/neuroexcitatory cytokine interleukin-1beta (IL-1beta); these events were attenuated by S1PR1 antagonists.	Naloxone	50-58	interleukin 1 beta	Mus musculus	194-211
33028294-10	2020	Piperine markedly decreased the total and differential white blood cell (WBC) count, the serum levels of lipopolysaccharide (LPS) and pro-inflammatory cytokines such as galectin-3 (Gal-3) and interleukin-1beta (IL-1beta).	piperine	0-8	interleukin 1 beta	Mus musculus	192-209
33116413-0	2020	EGCG Upregulates UCP3 Levels to Protect MIN6 Pancreatic Islet Cells from Interleukin-1beta-Induced Apoptosis.	epigallocatechin gallate	0-4	interleukin 1 beta	Mus musculus	73-90
33116413-1	2020	Objective: The protective effects of epigallocatechin gallate (EGCG) on interleukin-1beta (IL-1beta)-induced apoptosis were investigated in murine MIN6 pancreatic beta-cells.	epigallocatechin gallate	37-61	interleukin 1 beta	Mus musculus	72-89
33116413-1	2020	Objective: The protective effects of epigallocatechin gallate (EGCG) on interleukin-1beta (IL-1beta)-induced apoptosis were investigated in murine MIN6 pancreatic beta-cells.	epigallocatechin gallate	63-67	interleukin 1 beta	Mus musculus	72-89
33110918-13	2020	Acrolein exposure resulted in an increased expression of IL-17A, C, and D; IL-1B; IL-22; and RAR-related orphan receptor A in the PBEC-ALI model.	Acrolein	0-8	interleukin 1 beta	Mus musculus	75-80
32429710-7	2020	The increased productions of inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), and IL-6 in MPP+-treated BV-2 cells were also suppressed by PLD.	mangion-purified polysaccharide (Candida albicans)	135-139	interleukin 1 beta	Mus musculus	93-110
31820078-8	2020	10-HDA inhibited the activation of the TNF-alpha/NF-kappaB axis and NLRP3 inflammasome-IL-1beta pathway, which may be the anti-neuroinflammatory mechanism of 10-HDA.	10-hydroxy-2-decenoic acid	0-6	interleukin 1 beta	Mus musculus	87-95
31820078-8	2020	10-HDA inhibited the activation of the TNF-alpha/NF-kappaB axis and NLRP3 inflammasome-IL-1beta pathway, which may be the anti-neuroinflammatory mechanism of 10-HDA.	10-hydroxy-2-decenoic acid	158-164	interleukin 1 beta	Mus musculus	87-95
31820078-11	2020	Inhibition of FOXO1 and autophagy using chemical inhibitors markedly blunted the effect of 10-HDA on the TNF-alpha pathway and NLRP3 inflammasome-IL-1beta pathway, indicating that 10-HDA alleviates neuroinflammation in BV-2 cells by modulating FOXO1-mediated autophagy.	10-hydroxy-2-decenoic acid	180-186	interleukin 1 beta	Mus musculus	146-154
32540565-10	2020	Furthermore, BPA up-regulated the expression of Toll-like receptor 4 (TLR4) and phosphorylation of nuclear factor-kappa B (NF-kappaB) in the liver and increased the production of inflammatory cytokines, including interleukin-1beta, interleukin-18, tumour necrosis factor-alpha, and interleukin-6.	bisphenol A	13-16	interleukin 1 beta	Mus musculus	213-230
32945406-2	2020	The present study aimed to investigate the role of different MAPK signal transduction pathways in the interleukin-1beta (IL-1beta)-induced inhibition of glucose-stimulated insulin secretion (GSIS) in Min6 mouse pancreatic cells.	Glucose	153-160	interleukin 1 beta	Mus musculus	102-119
32989198-4	2020	Results: Analysis indicated that serum tumor necrosis factor-alpha, interleukin-1 beta, and prostaglandin E2 (PGE2) cytokine levels and PGE2 levels in the paw tissue of the mice were decreased by Zhongyi paste treatment.	zhongyi paste	196-209	interleukin 1 beta	Mus musculus	68-86
32886103-6	2020	It is noting that in response to oxLDL challenge, piceatannol abated the pyroptosis in RAW264.7 cells, with a decreased expression of caspase1, GSDMD, IL-18, IL-1b and NLRP3.	3,3',4,5'-tetrahydroxystilbene	50-61	interleukin 1 beta	Mus musculus	158-163
33029120-7	2020	More importantly, cisplatin induced activations of perivascular-resident macrophage-like melanocytes (PVM/Ms) and interleukin-1beta (IL-1beta) as well as increased expressions of profibrotic proteins such as laminin and collagen IV in SV.	Cisplatin	18-27	interleukin 1 beta	Mus musculus	114-131
32966478-11	2020	Immunohistochemical staining further showed that quercetin reduced the activation of NF-kappaB, the expression of interleukin-1beta and TNF-alpha, and the infiltration of granulocytes in retinal tissues.	Quercetin	49-58	interleukin 1 beta	Mus musculus	114-131
32977419-7	2020	In rotenone-treated BV2 cells, PQQ dose-dependently decreased lactate dehydrogenase (LDH) release and suppressed the up-regulation of pro-inflammation factors, such as interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha) in the cultured media, as well as nitric oxide (NO) release induced by rotenone.	Rotenone	3-11	interleukin 1 beta	Mus musculus	168-185
32977419-7	2020	In rotenone-treated BV2 cells, PQQ dose-dependently decreased lactate dehydrogenase (LDH) release and suppressed the up-regulation of pro-inflammation factors, such as interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha) in the cultured media, as well as nitric oxide (NO) release induced by rotenone.	PQQ Cofactor	31-34	interleukin 1 beta	Mus musculus	168-185
32512418-7	2020	High Cu intake also up-regulated expression levels of some pro-inflammatory mediators such as interleukin-2 (IL-2), interleukin-1beta (IL-1beta), and interleukin-8 (IL-8), and down-regulated the levels of expression of transforming growth factor beta (TGF-beta), an anti-inflammatory mediator.	Copper	5-7	interleukin 1 beta	Mus musculus	116-133
32750218-8	2020	Abx + DSF/Cu2+ significantly reduced the pro-inflammatory cytokines Interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor alpha (TNF-alpha) in tumors, and significantly reduced the expression of phosphorylated-protein kinase B (p-AKT)/protein kinase B (AKT), toll-like receptors 4 (TLR-4), and phosphorylated- nuclear factor kappa-B (p-NFkappaB)/NFkappaB in tumors.	CHEMBL369125	0-3	interleukin 1 beta	Mus musculus	68-85
32942769-8	2020	Here, we show that succinate can suppress secretion of inflammatory mediators IL-6, tumor necrosis factor (TNF) and nitric oxide (NO), as well as inhibit Il1b mRNA expression of inflammatory macrophages in a SUCNR1-independent manner.	Succinic Acid	19-28	interleukin 1 beta	Mus musculus	154-158
32894124-6	2020	PM014 treatment downregulated the pro-inflammatory cytokine expressions including IL-1b, IL-8, IL-6, TNF-alpha, IL-21 and IL-17.	pm014	0-5	interleukin 1 beta	Mus musculus	82-87
32894124-7	2020	ELISA analysis also showed reduced production of IL-1b, IL-6 and IL-17 in PM014-treated mice.	pm014	74-79	interleukin 1 beta	Mus musculus	49-54
32952341-10	2020	RESULTS: The resveratrol treatment group showed a 1.72-fold decrease in disease activity index scores and 1.42, 3.81, and 1.65-fold decrease in the production of the inflammatory cytokine tumor necrosis factor-alpha, interleukin-6 and interleukin-1beta, respectively, in DSS-induced colitis mice compared with DSS group (P < 0.05).	Resveratrol	13-24	interleukin 1 beta	Mus musculus	235-252
32540418-5	2020	Application of CP-99994, a selective antagonist of NK1R, inhibited the production of inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), interleukin 1 beta (IL-1beta), IL-6, inducible macrophage-type nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) in activated BV2 cells.	3-(2-methoxybenzylamino)-2-phenylpiperidine	15-23	interleukin 1 beta	Mus musculus	157-175
32750218-8	2020	Abx + DSF/Cu2+ significantly reduced the pro-inflammatory cytokines Interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor alpha (TNF-alpha) in tumors, and significantly reduced the expression of phosphorylated-protein kinase B (p-AKT)/protein kinase B (AKT), toll-like receptors 4 (TLR-4), and phosphorylated- nuclear factor kappa-B (p-NFkappaB)/NFkappaB in tumors.	dsf	6-9	interleukin 1 beta	Mus musculus	68-85
32742328-6	2020	It was noted that quercetin attenuated the KA-induced seizure score and proinflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and activation of nuclear factor kappaB (NF-kappaB) in mice.	Quercetin	18-27	interleukin 1 beta	Mus musculus	163-180
32301840-7	2020	Targeting S1PR1 reduced morphine-induced neuroinflammatory events in the dorsal horn of the spinal cord: increased glial marker expression, mitogen-activated protein kinase p38 and nuclear factor kappaB activation and increased inflammatory cytokine expression, such as interleukin-1beta, a cytokine central in the modulation of opioid-induced neural plasticity.	Morphine	24-32	interleukin 1 beta	Mus musculus	270-287
32867139-9	2020	Moreover, the values of tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma secreted from macrophages were increased following LJFE treatment.	ljfe	144-148	interleukin 1 beta	Mus musculus	53-70
32784362-5	2020	SsnB administration restored a normal tight junction protein profile with an increase in Occludin and a parallel decrease in Claudin 2 and inflammatory mediators high mobility group box 1 (HMGB1), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) in the distal intestine.	sparstolonin B	0-4	interleukin 1 beta	Mus musculus	197-214
32369227-9	2020	Furthermore, inhibition of miR-103a-3p repressed LPS-caused inflammation through downregulating expression of tumor necrosis factor (TNF-alpha), interleukin 1 beta (IL-1beta), and interleukin 6 in vitro and in vivo.	103a	31-35	interleukin 1 beta	Mus musculus	145-163
32770524-5	2020	Astragalin was found also to suppress the inflammatory signaling in the inflamed tissue as exhibited by the decreased myeloperoxidase activity along with the decreased protein and transcriptional level of pro-inflammatory cytokines including tumor necrosis factor-alpha, interleukin-1 beta and interleukin-6.	astragalin	0-10	interleukin 1 beta	Mus musculus	271-289
32619849-4	2020	Both Raftilose P95 and alpha3-Sialyllactose oligosaccharides upregulated PGlyRP3 and showed an anti-colitis effect as evidenced by increased survival and reductions in body weight loss, bleeding in stool, diarrhea, and the expression of the cytokine genes IL6, IL1b and TNFalpha.	Oligosaccharides	44-60	interleukin 1 beta	Mus musculus	261-265
30536265-10	2020	Treatment of RAW264.7 cells with thiaproline significantly ameliorated LPS-induced iNOS expression, while pipecolic acid inhibited LPS-induced IL-1beta expression.	pipecolic acid	106-120	interleukin 1 beta	Mus musculus	143-151
32626961-5	2020	SB203580 inhibited LPS-induced lung injury and proinflammatory cytokine expression, including tumor necrosis factor-alpha and interleukin-1beta.	SB 203580	0-8	interleukin 1 beta	Mus musculus	126-143
31849082-9	2020	After direct treatment with EtOH-Exo, IL-1beta expression was significantly increased in WT Kupffer cells but not in TLR3 KO Kupffer cells, augmenting IL-17A production of gammadelta T cells in mice and humans.	piperazine hydroxyethylamine	28-32	interleukin 1 beta	Mus musculus	38-46
31575337-10	2020	Additionally, IL-1beta and CD45 + cells were reduced in the ipsilateral cortex following ATN-161 administration.	ATN-2	89-96	interleukin 1 beta	Mus musculus	14-22
32801992-4	2020	Aplysin intervention was able to alleviate spontaneous pancreatic necrosis in NOD mice, accompanied with decreased serum endotoxin levels and downregulated expressions of Toll-like receptor 4 and its related molecules MyD88, TRAF-6, NF-kappaB p65, TRIF, TRAM, and IRF-3, as well as protein levels of interleukin-1beta and interferon-beta in pancreatic tissues.	aplysin	0-7	interleukin 1 beta	Mus musculus	300-317
32325086-13	2020	In organoids derived from pL2-IL1B mice, the NF-kappaB inhibitor JSH-23 reduced cell survival and proliferation.	4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine	65-71	interleukin 1 beta	Mus musculus	30-34
32521492-6	2020	Meanwhile, the reduction of 5-HT and increase of interleukin 1 beta (IL-1beta) in median raphe nucleus and cortex indicated potential mechanisms underlying MI-induced depression-like behaviors, which were significantly reserved by GB treatment.	ginkgolide B	231-233	interleukin 1 beta	Mus musculus	49-67
32464599-4	2020	In the first experiment, we determined that the inhibitory effect of peripheral interleukin-1beta on luteinizing hormone secretion was enhanced by estradiol.	Estradiol	147-156	interleukin 1 beta	Mus musculus	80-97
32048261-13	2020	Bax Bcl-2-associated X protein, Bcl2 B-cell lymphoma 2, MMF Mycophenolate mofetil, Con A Concanavalin A, GSH reduced glutathione, HO-1 Heme oxygenase-1, IL-1beta Interleukin-1beta, IFN-gamma Interferon-gamma, MDA Malondialdehyde, NF-kappaB Nuclear Factor Kappa B, Nrf2 Nuclear factor erythroid 2-related factor 2, NO Nitric Oxide, SOD Superoxide Dismutase, TLR4 Toll-like receptor 4, TNF-alpha tumor necrosis factor-alpha.	Glutathione	117-128	interleukin 1 beta	Mus musculus	162-179
32464599-5	2020	We next utilized serial sampling and showed that interleukin-1beta reduced the frequency of luteinizing hormone pulses in ovariectomized female mice treated with estradiol.	Estradiol	162-171	interleukin 1 beta	Mus musculus	49-66
32464599-8	2020	We next tested the hypothesis that estradiol enhances the activation of brainstem nuclei responding to interleukin-1beta.	Estradiol	35-44	interleukin 1 beta	Mus musculus	103-120
32048261-9	2020	Moreover, MMF significantly reduced Con A-induced increase in the expression of hepatic toll-like receptor 4 (TLR4), nuclear factor kappa-B (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (INF-gamma) and interleukin-1beta (Il-1beta).	mycophenolate mofetil	10-13	interleukin 1 beta	Mus musculus	227-244
32848767-0	2020	Luteoloside Exerts Analgesic Effect in a Complete Freund"s Adjuvant-Induced Inflammatory Model via Inhibiting Interleukin-1beta Expression and Macrophage/Microglia Activation.	luteolin-7-glucoside	0-11	interleukin 1 beta	Mus musculus	110-127
31490354-3	2020	In an aerosolized bacterial lipopolysaccharide (LPS) inhalation mouse model of ALI, we found that administration of mortalin/GRP75 inhibitor MKT-077, both prophylactically and therapeutically, protected against PMN influx into alveolar airspaces, microvascular leakage and expression of pro-inflammatory mediators such as IL-1beta, E-selectin and TNFalpha.	MKT 077	141-148	interleukin 1 beta	Mus musculus	322-330
32848767-8	2020	Luteoloside inhibited interleukin-1beta expression in plantar tissue, dorsal root ganglion, the dorsal horn of spinal cord, and serum, after 14 days of continuous administration.	luteolin-7-glucoside	0-11	interleukin 1 beta	Mus musculus	22-39
32821334-11	2020	Ipragliflozin had no appreciable effects on hepatic oxidative stress-related gene expression levels or macrophage infiltration, but significantly reduced hepatic interleukin-1beta (IL-1beta) mRNA expression levels.	ipragliflozin	0-13	interleukin 1 beta	Mus musculus	162-179
32691626-3	2022	It was suggested that the portulacatone A (1) can significantly inhibit the inflammatory factor, interleukin-1beta (IL-1beta) in the RAW 264.7 cells induced by LPS.	portulacatone a (1)	26-45	interleukin 1 beta	Mus musculus	97-114
32708004-5	2020	These seven furanocembranolides were screened in vitro by measuring their ability to modulate interleukin-1beta (IL-1beta) production by microglial BV2 cells after LPS (lipopolysaccharide) stimulation.	furanocembranolide	12-31	interleukin 1 beta	Mus musculus	94-111
32650550-4	2020	The anti-inflammatory activity of 7AC on viability of treated cells was assessed by measuring the level of expression of NO, PGE2 and pro-inflammatory cytokines, namely interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in 7AC-treated RAW 264.7 macrophages.	7-acetoxycoumarin	34-37	interleukin 1 beta	Mus musculus	169-186
32421368-12	2020	We found that mTORC1 inhibition with low doses of rapamycin (2, 20 nM) lowered macrophage priming of IL-1b mRNA and secretion of IL-1b caused by multiple statins.	Sirolimus	50-59	interleukin 1 beta	Mus musculus	101-106
32665906-10	2020	Results: We show that activation of PPARgamma by its agonist, pioglitazone, reduces cell proliferation, Tlr-4, Myd-88, Nf-kb mRNA expression, and tumor necrosis factor-alpha (TNF-alpha) production but not interleukin-1 beta (IL-1beta) in B16F10 LPS-stimulated cells in vitro.	Pioglitazone	62-74	interleukin 1 beta	Mus musculus	205-223
32421368-12	2020	We found that mTORC1 inhibition with low doses of rapamycin (2, 20 nM) lowered macrophage priming of IL-1b mRNA and secretion of IL-1b caused by multiple statins.	Sirolimus	50-59	interleukin 1 beta	Mus musculus	129-134
31650468-12	2020	In the gut tissues, BE treatment significantly reduced inflammatory cytokine levels such as IL-1beta, IL-2, IL-6, IL-10, G-CSF, and GM-CSF.	baicalein	20-22	interleukin 1 beta	Mus musculus	92-100
31500508-8	2020	In brief, the present study for the first time demonstrates that LIPUS inhibits the production of mature IL1B partially via SQSTM1-dependent autophagic degradation of PKM2 in LPS-ATP-treated macrophages, which may further ameliorate the synovial inflammation and gait patterns in animal models.	Adenosine Triphosphate	179-182	interleukin 1 beta	Mus musculus	105-109
32289314-9	2020	5-BDBD treatment significantly (p < .05) reduced infarct volume, neurological deficit (ND) score, levels of cytokine interleukin-1 beta (IL-1beta) and blood brain barrier (BBB) permeability in the 3-day group.	5-(3-bromophenyl)-1,3-dihydro-2H-benzofuro(3,2-e)-1,4-diazepin-2-one	0-6	interleukin 1 beta	Mus musculus	117-135
32617042-7	2020	Diol-GF and diol-ginsenoside Rb1 significantly decreased tumor necrosis factor alpha production, whereas diol-ginsenosides Rb1 and Rd decreased interleukin 1beta production in RAW264.7 cells.	diol-ginsenosides	105-122	interleukin 1 beta	Mus musculus	144-161
32413737-8	2020	Meanwhile, costunolide also suppressed DSS-induced expression of induced nitric oxide synthase (iNOS), interleukin-1beta (IL-1beta), IL-6, tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) in both mRNA and protein levels.	costunolide	11-22	interleukin 1 beta	Mus musculus	103-120
32413737-8	2020	Meanwhile, costunolide also suppressed DSS-induced expression of induced nitric oxide synthase (iNOS), interleukin-1beta (IL-1beta), IL-6, tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) in both mRNA and protein levels.	Dextran Sulfate	39-42	interleukin 1 beta	Mus musculus	103-120
32510137-0	2020	The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice.	Canagliflozin	20-33	interleukin 1 beta	Mus musculus	65-83
31578565-8	2020	The mice treated with ITC/Thal and CMX/Thal showed intense weight loss, increased deposition of reticulin fibers, high pulmonary concentrations of CCL3, IFN-gamma and VEGF, and decreased concentrations of IL-6, IL-1beta, IL-17, and TGF-beta1.	Itraconazole	22-25	interleukin 1 beta	Mus musculus	211-219
31578565-8	2020	The mice treated with ITC/Thal and CMX/Thal showed intense weight loss, increased deposition of reticulin fibers, high pulmonary concentrations of CCL3, IFN-gamma and VEGF, and decreased concentrations of IL-6, IL-1beta, IL-17, and TGF-beta1.	Thalidomide	26-30	interleukin 1 beta	Mus musculus	211-219
31578565-8	2020	The mice treated with ITC/Thal and CMX/Thal showed intense weight loss, increased deposition of reticulin fibers, high pulmonary concentrations of CCL3, IFN-gamma and VEGF, and decreased concentrations of IL-6, IL-1beta, IL-17, and TGF-beta1.	Trimethoprim, Sulfamethoxazole Drug Combination	35-38	interleukin 1 beta	Mus musculus	211-219
31578565-8	2020	The mice treated with ITC/Thal and CMX/Thal showed intense weight loss, increased deposition of reticulin fibers, high pulmonary concentrations of CCL3, IFN-gamma and VEGF, and decreased concentrations of IL-6, IL-1beta, IL-17, and TGF-beta1.	Thalidomide	39-43	interleukin 1 beta	Mus musculus	211-219
31898284-10	2020	Met-RANTES treatment decreased expressions of CCR1, TPR1, p-ERK, TNF-alpha, and IL-1beta, which was reversed by ceramide C6.	methionylmethionine	0-3	interleukin 1 beta	Mus musculus	80-88
31898284-10	2020	Met-RANTES treatment decreased expressions of CCR1, TPR1, p-ERK, TNF-alpha, and IL-1beta, which was reversed by ceramide C6.	Ceramides	112-120	interleukin 1 beta	Mus musculus	80-88
32363440-6	2020	Consistently, gelsemine inhibited the over-expression of pro-inflammatory cytokines, including interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), in the brain of mice.	gelsemine	14-23	interleukin 1 beta	Mus musculus	95-112
31339809-9	2020	Rebamipide up-regulated the mRNA expressions of COL2A, TIMP3, TGFbeta, and FGF2 in chondrocytes and down-regulated IL-1beta, TNFalpha, NF-kappaB, MMP3, MMP13, and ADAMTS5.	rebamipide	0-10	interleukin 1 beta	Mus musculus	115-123
32377744-5	2020	The present study demonstrated that the treatment of macrophages with ciprofloxacin was able to promote the production of interleukin-1beta, tumor necrosis factor-alpha and the polarization of CD86+CD206- macrophages, while inhibiting the polarization of CD86-CD206+ macrophages.	Ciprofloxacin	70-83	interleukin 1 beta	Mus musculus	122-139
32606350-7	2020	The significant elevation and reduction in the hippocampus of relative mRNA levels of brain-derived neurotrophic factor and interleukin 1beta, respectively, also showed the neuroprotective role of GORZ in ethanol-induced anxiety.	gamma-oryzanol	197-201	interleukin 1 beta	Mus musculus	124-141
32606350-7	2020	The significant elevation and reduction in the hippocampus of relative mRNA levels of brain-derived neurotrophic factor and interleukin 1beta, respectively, also showed the neuroprotective role of GORZ in ethanol-induced anxiety.	Ethanol	205-212	interleukin 1 beta	Mus musculus	124-141
31937929-7	2020	Furthermore, oroxindin treatment significantly inhibited the generation of IL-1beta and IL-18 in the colon via inhibiting the nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasome formation and activation.	oroxindin	13-22	interleukin 1 beta	Mus musculus	75-83
32597088-7	2020	The expression level of tumor necrosis factor-alpha (TNF -alpha), interleukin-1beta (IL-1beta) and transforming growth factor-beta1 (TGF-beta1) in SNE group was significantly lower than that of the NT group on 7 d ( P < 0.05).	(-)-Sabinene	147-150	interleukin 1 beta	Mus musculus	66-83
32472783-0	2020	Salvianolic acid B decreases interleukin-1beta-induced colitis recurrence in mice.	salvianolic acid B	0-18	interleukin 1 beta	Mus musculus	29-46
32566254-5	2020	Inhibitors of Kdm6a and Kdm6b robustly abolished Zol-enhanced interleukin 1beta synthesis and secretion from macrophages.	Zoledronic Acid	49-52	interleukin 1 beta	Mus musculus	62-79
32655468-6	2020	The western blot results showed that the expression levels of inflammatory factors tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) were reduced by piperine.	piperine	172-180	interleukin 1 beta	Mus musculus	127-144
31935134-4	2020	STZ-treated mice exhibited significant enhancement in brain thiobarbituric acid reactive species, interleukin-1beta, tumour necrosis factor-alpha, myeloperoxidase, and acetylcholinestrase activity in addition to diminution in glutathione levels and superoxide dismutase activity in comparison to untreated mice.	Streptozocin	0-3	interleukin 1 beta	Mus musculus	98-115
31897918-11	2020	Consequently, decreased reactive oxygen species levels and suppressed proinflammatory cytokine production were confirmed in casticin-treated IL-1beta-stimulated ADTC5 cells.	Oxygen	33-39	interleukin 1 beta	Mus musculus	141-149
31916050-6	2020	Additionally, Y-27632 treatment significantly decreased CD68 and proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-17F (IL-17F), and interleukin-6 (IL-6).	Y 27632	14-21	interleukin 1 beta	Mus musculus	140-157
31916050-6	2020	Additionally, Y-27632 treatment significantly decreased CD68 and proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-17F (IL-17F), and interleukin-6 (IL-6).	Y 27632	14-21	interleukin 1 beta	Mus musculus	159-167
31845444-7	2020	The EtOAc-soluble fraction decreased the interleukin-1beta mRNA expression, as well as hepatic lipid accumulation in hepatocytes.	ethyl acetate	4-9	interleukin 1 beta	Mus musculus	41-58
32279045-6	2020	Furthermore, western blotting and the results of morphological analysis revealed that shikonin treatments markedly reduced D-gal induced neuroinflammation through inhibition of astrocytosis as determined by glial fibrillary acidic protein (GFAP) detection, and downregulating other inflammatory mediators, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6.	shikonin	86-94	interleukin 1 beta	Mus musculus	357-374
31675438-10	2020	Furthermore, the ligature-induced number of macrophages and neutrophils as well as the expression of interleukin 1-beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) were considerably lower in the periodontal tissues following shogaol injection.	shogaol	236-243	interleukin 1 beta	Mus musculus	101-119
32509163-5	2020	Additionally, Melatonin reduced the levels of inflammatory factors in kidney such as interleukin-1beta, monocyte chemotactic protein-1 and active nuclear factor-kappaB though toll-like receptor 4 signaling pathway (TLR4).	Melatonin	14-23	interleukin 1 beta	Mus musculus	85-102
31796364-9	2020	In addition, BDE-47 elevated the expression of the cytokines TNFRSF12A, TNF-alpha, IL-1beta and IL-6, and lowered the cytokines SOCS3 and the nuclear receptor PPARalpha.	2,2',4,4'-tetrabromodiphenyl ether	13-19	interleukin 1 beta	Mus musculus	83-91
32394642-5	2022	Overexpression of miR-142-5p in a cardiomyocyte model of H/R enhanced apoptosis and increased the expression of interleukin-1beta (IL-1beta), cleaved-caspase 3 and p62, but inhibited autophagy and decreased expression of Beclin-1, protein 1 light chain 3B (LC3B) and B cell leukemia/lymphoma 2 (Bcl-2) at the mRNA and protein level.	mir-142-5p	18-28	interleukin 1 beta	Mus musculus	112-129
31883118-11	2020	The in vivo effects of eucalyptol on ankle edema, mechanical allodynia, NLRP3 inflammasome, IL-1beta and TRPV1 expression were mimicked by treating MSU-injected mice with anti-oxidants.	eucalyptol	23-33	interleukin 1 beta	Mus musculus	92-100
32084361-7	2020	(+)-Naltrexone suppressed the cPAF-induced expression of inflammatory cytokine genes, Il1b, Il6, and Il10 in the decidua, Il6, Il12b, and Il10 in the myometrium, and Il1b and Il6 in the placenta.	Naltrexone	0-14	interleukin 1 beta	Mus musculus	86-90
32084361-7	2020	(+)-Naltrexone suppressed the cPAF-induced expression of inflammatory cytokine genes, Il1b, Il6, and Il10 in the decidua, Il6, Il12b, and Il10 in the myometrium, and Il1b and Il6 in the placenta.	Naltrexone	0-14	interleukin 1 beta	Mus musculus	166-170
32084361-7	2020	(+)-Naltrexone suppressed the cPAF-induced expression of inflammatory cytokine genes, Il1b, Il6, and Il10 in the decidua, Il6, Il12b, and Il10 in the myometrium, and Il1b and Il6 in the placenta.	1-O-hexadecyl-2-N-methylcarbamylphosphatidylcholine	30-34	interleukin 1 beta	Mus musculus	86-90
32084361-7	2020	(+)-Naltrexone suppressed the cPAF-induced expression of inflammatory cytokine genes, Il1b, Il6, and Il10 in the decidua, Il6, Il12b, and Il10 in the myometrium, and Il1b and Il6 in the placenta.	1-O-hexadecyl-2-N-methylcarbamylphosphatidylcholine	30-34	interleukin 1 beta	Mus musculus	166-170
31883118-11	2020	The in vivo effects of eucalyptol on ankle edema, mechanical allodynia, NLRP3 inflammasome, IL-1beta and TRPV1 expression were mimicked by treating MSU-injected mice with anti-oxidants.	Uric Acid	148-151	interleukin 1 beta	Mus musculus	92-100
32149839-12	2020	In contrast, after delayed infection monocytes from TBI + Sp mice had higher levels of interleukin-1beta, tumor necrosis factor-alpha, and reactive oxygen species when compared with Sham + Sp mice.	Thioacetazone	52-55	interleukin 1 beta	Mus musculus	87-133
31696375-9	2020	Atorvastatin reversed all these alterations in parallel with a decrease in circulating levels of cytokines (IL-1beta, IL-4, IL-6, and TNF-alpha) in plasma, inhibited the activities of oxidative stress parameters (lower TBARS levels, ratio of GSH/GSSH, and activities of SOD and CAT), enhanced the activity of citrate synthase in brain, and reduced the number of astrocytes and neuronal cell deaths in CA3 region of hippocampus.	atorvastatin	0-12	interleukin 1 beta	Mus musculus	108-116
32149839-12	2020	In contrast, after delayed infection monocytes from TBI + Sp mice had higher levels of interleukin-1beta, tumor necrosis factor-alpha, and reactive oxygen species when compared with Sham + Sp mice.	TFF2 protein, human	58-60	interleukin 1 beta	Mus musculus	87-133
31774188-11	2020	4-MU also exerted pronounced chondro-protective effects on murine joint cartilage exposed to IL1beta in vitro and, blocked IL1beta-enhanced lactate production in cartilage explants.	Hymecromone	0-4	interleukin 1 beta	Mus musculus	93-100
32377661-6	2020	Additionally, Pts remarkably reversed the LPS-induced inhibition of interleukin-10 and the release of tumor necrosis factor-alpha, interleukin-6 and interleukin-1beta.	pterostilbene	14-17	interleukin 1 beta	Mus musculus	149-166
31774188-11	2020	4-MU also exerted pronounced chondro-protective effects on murine joint cartilage exposed to IL1beta in vitro and, blocked IL1beta-enhanced lactate production in cartilage explants.	Hymecromone	0-4	interleukin 1 beta	Mus musculus	123-130
32047914-10	2020	In efferocytic macrophages, PCA at 0.5 and 1 mumol/L inhibited Il1b/IL-1beta mRNA (27.2-46.5%) and protein (29.2-49.6%) expression and NF-kappaB activation (67.0-80.3%) by upregulation of MER proto-oncogene tyrosine kinase (MERTK) and inhibition of mitogen-activated protein kinase 3/1 (MAPK3/1).	protocatechuic acid	28-31	interleukin 1 beta	Mus musculus	63-67
31774188-11	2020	4-MU also exerted pronounced chondro-protective effects on murine joint cartilage exposed to IL1beta in vitro and, blocked IL1beta-enhanced lactate production in cartilage explants.	Lactic Acid	140-147	interleukin 1 beta	Mus musculus	123-130
31771816-5	2020	NaHS significantly increased the expressions of tight junction proteins (i.e., ZO-1, Occludin and claudin-1), and reduced apoptosis and secretion of pro-inflammatory cytokines (i.e., TNF-alpha, IL-6 and IL-1beta) in CS-exposed mouse lungs and CSE-incubated A549 cells, indicating H2S inhibits CS-induced inflammation, injury and apoptosis in alveolar epithelial cells.	Sodium	0-4	interleukin 1 beta	Mus musculus	203-211
31965510-5	2020	Biochemical analysis showed that CPF administration was associated with significant increases in the serum concentrations of interleukin-1beta, IL-6, and tumor necrosis factor-alpha, while it was associated with significant reductions in serum AChE levels in mice.	1-(p-fluorphenacyl)-2-methyl-4-nitroimidazole	33-36	interleukin 1 beta	Mus musculus	125-142
31552548-3	2020	The results showed that CAR caused hemorrhaging and exudation of lung tissues and the release of inflammatory factors (TNF-alpha, IL-6 and IL-1beta), effects that were significantly reduced by treatment with Ori.	oridonin	208-211	interleukin 1 beta	Mus musculus	139-147
32467879-8	2020	In transgenic AD mice, sildenafil was found to rescue deficits in CREB phosphorylation and memory, upregulate brain-derived neurotrophic factor, reduce reactive astrocytes and microglia, decrease interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha, decrease neural apoptosis, increase neurogenesis, and reduce tau hyperphosphorylation.	Sildenafil Citrate	23-33	interleukin 1 beta	Mus musculus	196-213
32295623-7	2020	Mechanistically, the newly identified nucleotide-binding leucine-rich repeat-containing receptor (NLR) family pyrin domain-containing 12 (NLRP12) collaborated with NLR family pyrin domain-containing 3 (NLRP3) and NLR family CARD domain-containing protein 4 (NLRC4) downstream of the CASP8-HIF-1alpha axis, to elicit pyroptotic processes and interleukin-1beta (IL-1beta) maturation through caspase-1 activation, facilitating pyroptosis and neuroinflammation in acute glaucoma.	Leucine	57-64	interleukin 1 beta	Mus musculus	341-358
31931676-10	2020	DOX causes depression after 6 and 24 h in TNF-alpha content and Per2 gene expression after 24 h IL-1beta expression was reduced also.	Doxorubicin	0-3	interleukin 1 beta	Mus musculus	96-104
31758699-9	2020	Besides, NGN also inhibited lipid deposition, NLRP3 and IL-1beta expression in WT hepatocytes, but lost efficacy in NLRP3-/- hepatocytes.	naringenin	9-12	interleukin 1 beta	Mus musculus	56-64
32489561-7	2020	Results: Our data indicated that inflammatory cytokines including interleukin-1beta (IL-1beta), IL-6, tumor necrosis factor-alpha (TNF-alpha) and nitric oxide were suppressed by Monascin treatment.	monascin	178-186	interleukin 1 beta	Mus musculus	66-83
31776889-7	2020	Topical application of PNA or Delta7-ETrA on mouse back skin suppressed TPA-induced pro-inflammatory mediator production, including IL-1beta, IL-6, TNF-alpha, and PGE2, as well as the phosphorylation of p38- and JNK-mitogen-activated protein kinase (MAPK), but not that of ERK-MAPK.	5,9,12-octadecatrienoic acid	23-26	interleukin 1 beta	Mus musculus	132-140
32070920-5	2020	Moreover, SAMC displayed an anti-inflammatory effect through reducing inflammatory cells infiltration, myeloperoxidase (MPO) formation and inhibiting pro-inflammatory cytokines/mediator production including tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX2) via suppressing the activation of nuclear factor-kappaB (NF-kappaB) signaling pathway.	S-allylmercaptocysteine	10-14	interleukin 1 beta	Mus musculus	248-265
31832909-9	2020	In addition, ELISA and Western blot results revealed that Phil inhibits the activation of the NF-kappaB and MAPK signaling pathways and decreases the levels of inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in LPS-induced ARDS mice.	phillyrin	58-62	interleukin 1 beta	Mus musculus	184-192
32186945-6	2020	MCG-PC significantly suppressed colonic neoplasia and decreased the levels of various cytokines (tumor necrosis factor: Tnf, interleukin 1 beta: Il1b, interleukin 6: Il6, and interferon gamma: Ifngamma) in serum and colon tissue of the CRC mice.	mcg-pc	0-6	interleukin 1 beta	Mus musculus	125-143
32186945-6	2020	MCG-PC significantly suppressed colonic neoplasia and decreased the levels of various cytokines (tumor necrosis factor: Tnf, interleukin 1 beta: Il1b, interleukin 6: Il6, and interferon gamma: Ifngamma) in serum and colon tissue of the CRC mice.	mcg-pc	0-6	interleukin 1 beta	Mus musculus	145-149
32145511-4	2020	The inhibitory effect of muscone on microglia inflammatory activation was verified by measuring pro-inflammatory cytokines expression (interleukin-6, tumor necrosis factor-alpha, and interleukin-1beta; IL-6, TNF-alpha and IL-1beta).	muscone	25-32	interleukin 1 beta	Mus musculus	183-200
32033881-6	2020	Anti-inflammatory activity of QD was confirmed by the suppression of nitric oxide (NO) production in response to interleukin-1beta in cultured hepatocytes.	Nitric Oxide	69-81	interleukin 1 beta	Mus musculus	113-130
31846746-5	2020	RESULTS: UroA improved symptoms of diabetic mice such as high water intake volume, high urine volume, significantly decreased fasting blood glucose (FBG), after-glucose-loading glucose, glycated hemoglobin (GHb) levels, plasma C-peptide, malondialdehyde (MDA) and interleukin-1 beta level, increased reduced glutathione (GSH), interleukin-10 content, and glucose tolerance.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	9-13	interleukin 1 beta	Mus musculus	264-282
31862360-7	2020	Treatment with GDR-TPT nanoparticles resulted in a marked decrease in the infiltration of CD3+ T cells and F4/80+ macrophages and reduction of the expression of TNF-alpha, IL-6 and IL-1beta in the inflamed lesions of CIA mice.	triptolide	19-22	interleukin 1 beta	Mus musculus	181-189
32135404-6	2020	Functional studies revealed that DADS pre-treatment attenuated LPS-induced decreases in levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) mRNA as well as LPS-induced increases in levels of IL-10 and CD206 mRNA in both cultured microglia and prefrontal cortexes in mice.	diallyl disulfide	33-37	interleukin 1 beta	Mus musculus	142-159
31640402-10	2020	The protein levels of PD-L1 were significantly increased 2 h, 4 h and 6 h after treatment, and PD-1 was significantly increased at 2 h and 6 h. The blockade of PD-1 increased acute nitroglycerin-induced hyperalgesia, and this effect was accompanied by a more significant increase in calcitonin gene-related peptide, IL-1beta, TNF-alpha, IL-6 and IL-18 in the trigeminal ganglia.	Nitroglycerin	181-194	interleukin 1 beta	Mus musculus	316-324
32140392-0	2020	Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1 beta  expression.	Benzydamine	0-11	interleukin 1 beta	Mus musculus	91-109
32140392-5	2020	BA inhibited osteoclast differentiation and strongly suppressed interleukin-1beta (IL-1beta) production.	Benzydamine	0-2	interleukin 1 beta	Mus musculus	64-81
32123188-4	2020	Resveratrol also led to the polarization of macrophages to the M2 direction, as well as decreasing the expression of a number of M1 pro-inflammatory cytokines [tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta) and interleukin 6 (IL-6)].	Resveratrol	0-11	interleukin 1 beta	Mus musculus	201-219
31732967-7	2020	Furthermore, the increments of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) and TUNEL-positive apoptotic cells in MPTP-treated mice were ameliorated by miR-29c.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	127-131	interleukin 1 beta	Mus musculus	70-78
31931366-4	2020	DMB significantly inhibited the infiltration of CD4+ T cell and Kupffer cell as well as the expression of inflammatory cytokines, such as TNF-alpha, IL-6, IL-1beta and IFN-gamma by ELISA and qPCR analysis.	demethyleneberberine	0-3	interleukin 1 beta	Mus musculus	155-163
31837587-6	2020	The major phytochemicals of EFLA 945, resveratrol and peonidin 3-O-glucoside (P3G), appear to be the potential bioactive compounds responsible for its ability to restrict AIM2-dependent IL-1beta secretion.	resveratrol	38-49	interleukin 1 beta	Mus musculus	186-194
31837587-6	2020	The major phytochemicals of EFLA 945, resveratrol and peonidin 3-O-glucoside (P3G), appear to be the potential bioactive compounds responsible for its ability to restrict AIM2-dependent IL-1beta secretion.	peonidin 3-glucoside	54-76	interleukin 1 beta	Mus musculus	186-194
31837587-6	2020	The major phytochemicals of EFLA 945, resveratrol and peonidin 3-O-glucoside (P3G), appear to be the potential bioactive compounds responsible for its ability to restrict AIM2-dependent IL-1beta secretion.	peonidin 3-glucoside	78-81	interleukin 1 beta	Mus musculus	186-194
31860763-2	2020	In this study, our results indicated that eriodictyol could dramatically suppress the inflammatory mediators, including interleukin-6 (IL-6), IL-1beta, prostaglandin E2, and tumor necrosis factor-alpha in bronchoalveolar lavage fluid of LPS-challenged mice.	eriodictyol	42-53	interleukin 1 beta	Mus musculus	142-150
31918161-4	2020	In addition, the Nfkbiz+/- and Nfkbiz-/- mice significantly attenuated serum IL-1beta secretion in response to a monosodium urate injection, a NLRP3 trigger, when compared with Nfkbiz-+/+ mice.	Uric Acid	113-129	interleukin 1 beta	Mus musculus	77-85
31338841-5	2020	Methionine significantly elevated Hcy, TNF-a, H 2 S, and IL-1beta expression while decreasing the level of CSE in C57BL/6 mice.	Methionine	0-10	interleukin 1 beta	Mus musculus	57-65
32084579-7	2020	ALA significantly inhibited the secretion of proinflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) and increased anti-inflammatory cytokine.	alpha-Linolenic Acid	0-3	interleukin 1 beta	Mus musculus	147-164
31809762-6	2020	The results revealed that treatment with GW9508 could significantly ameliorate cognitive deficits of APP/PS1 mice, upregulate the expression levels of cAMP, p-CREB and neurotrophic factors in vivo, while GW9508 also ameliorate Abeta1-42-induced neuron damage and downregulate the expression levels of pathological protein such as p-JNK, JNK and apoptosis-related proteins such as IL-6, IL-1beta, TNF-alpha and caspase-3 in vitro.	GW9508	41-47	interleukin 1 beta	Mus musculus	386-394
31840571-8	2020	It further demonstrates that 2B viroporin activates NLRP3 inflammasome and induces IL-1beta in mice, which enhances the specific immune response against FMDV as an ideal self-adjuvant for FMD VLPs vaccine in guinea pigs.	2,5-dichloro-4-bromophenol	29-41	interleukin 1 beta	Mus musculus	83-91
32121228-7	2020	The results demonstrate that TA suppressed the lung histological changes in CS-exposed mice, as evidenced by the diminished generation of pro-inflammatory cytokines, including interleukin 1beta (IL-1beta), IL-2, IL-6, and tumor necrosis factor alpha (TNF-alpha).	Tantalum	29-31	interleukin 1 beta	Mus musculus	176-193
32139660-7	2020	Acetate also reduced expression of inflammatory proteins (tumor necrosis factor-alpha, interleukin-1beta and interleukin-6), oxidative stress factors (NADPH oxidase 2, inducible nitric oxide synthase and reactive oxygen species), and signaling molecules (nuclear factor kappa B and mitogen-activated protein kinase) in the hippocampus.	Acetates	0-7	interleukin 1 beta	Mus musculus	87-104
32106625-3	2020	IAA significantly ameliorated LPS-induced expression of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1) as well as generation of reactive oxidative species (ROS) and nitric oxide (NO).	indoleacetic acid	0-3	interleukin 1 beta	Mus musculus	56-73
32042047-5	2020	Induction of goblet cells was observed with melatonin administration, which was accompanied by suppression of Il1b and Il17a and induction of melatonin receptor and Reg3beta, an antimicrobial peptide (AMP) against Gram-negative bacteria.	Melatonin	44-53	interleukin 1 beta	Mus musculus	110-114
31939851-10	2020	Meanwhile, decreased expression of inflammatory mediators (TNF-alpha, interleukin 1beta, and interleukin 6), as well as decreased activation of astrocytes in the spinal cord, were found after 4-PBA or GSK2606414 treatment.	4-phenylbutylamine	192-197	interleukin 1 beta	Mus musculus	70-87
31697983-7	2020	Furthermore, ACT001 abolished MPTP-induced alpha-synuclein overexpression, astrocyte activation and interleukin-1beta (IL-1beta) production in the substantia nigra and striatum of the mouse brain.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	30-34	interleukin 1 beta	Mus musculus	100-117
31385191-8	2020	In addition, the levels of serum IL-1beta and LPS-binding protein were also decreased by ZnO treatment.	Zinc Oxide	89-92	interleukin 1 beta	Mus musculus	33-41
31939851-10	2020	Meanwhile, decreased expression of inflammatory mediators (TNF-alpha, interleukin 1beta, and interleukin 6), as well as decreased activation of astrocytes in the spinal cord, were found after 4-PBA or GSK2606414 treatment.	7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine	201-211	interleukin 1 beta	Mus musculus	70-87
32096189-17	2020	Fluoxetine could effectively reduce the content of TNF-a, IL-1b, and IL-6 (p<0.01) and increase the content of IL-10 (p<0.01).	Fluoxetine	0-10	interleukin 1 beta	Mus musculus	58-63
30990365-8	2020	Cocaine-mediated activation of microglia was further monitored by assessing the expression of the microglial marker (ITGAM) and the inflammatory cytokine (Tnf, Il1b, and Il6) mRNAs.	Cocaine	0-7	interleukin 1 beta	Mus musculus	160-164
31759747-7	2020	Correspondingly, acute 1-NP exposure upregulated pulmonary Il-1beta, Il-6, Tnf-alpha and Kc.	1-nitropyrene	23-27	interleukin 1 beta	Mus musculus	59-67
32172946-5	2020	Pretreatment with DP was able to restore serum liver characteristics (aspartate transaminase, AST; alanine aminotransferase, ALT; alkaline phosphatase, AKP), improve redox imbalance (superoxide dismutase, SOD; glutathione, GSH; malondialdehyde, MDA), and decrease inflammatory factors (tumor necrosis factor-alpha, TNF-alpha; interleukin-1beta, IL-1beta).	dp	18-20	interleukin 1 beta	Mus musculus	326-343
31453635-7	2020	Effects of IL-1beta on the development of embryo reduced in 20 ng/mL IL-1beta supplemented group when 5 mM 3-methyladenine (3-MA) was also added, which used to inhibit autophagy activation in endogenous PtdIns3Ks signal pathway.	3-methyladenine	107-122	interleukin 1 beta	Mus musculus	69-77
31909582-6	2020	In parallel, we also found that DHA-deficient mice were characterized by an increased expression of pro-inflammatory molecules, namely TNF, IL-1beta, iNOS, caspase-1 as well as the activation and morphologic changes of microglia in the absence of any brain injury or disease.	Docosahexaenoic Acids	32-35	interleukin 1 beta	Mus musculus	140-148
31646411-5	2020	DSS-induced MPO activity, MDA level, TNF-alpha, and IL-1beta production in colonic tissues were also suppressed by genipin.	genipin	115-122	interleukin 1 beta	Mus musculus	52-60
31863924-6	2020	Our results first demonstrated that DET attenuates LPS-induced interleukin-1beta (IL-1beta) and high-mobility group box 1 (HMGB1) release in vitro and in vivo and protected mice against lethal endotoxemia.	deoxyelephantopin	36-39	interleukin 1 beta	Mus musculus	63-80
31863924-6	2020	Our results first demonstrated that DET attenuates LPS-induced interleukin-1beta (IL-1beta) and high-mobility group box 1 (HMGB1) release in vitro and in vivo and protected mice against lethal endotoxemia.	deoxyelephantopin	36-39	interleukin 1 beta	Mus musculus	82-90
30574832-6	2020	We identified that AKT2 during homeostasis specifically regulates CLDN5-dependent barrier integrity in brain microvascular endothelial cells (BMVECs) and that intervention with a selective insulin-receptor (IR) agonist, demethylasterriquinone B1 (DMAQ-B1), rescued IL-1beta-induced AKT2 inactivation, FOXO1 nuclear accumulation, and loss of CLDN5-dependent barrier integrity.	demethylasterriquinone	220-242	interleukin 1 beta	Mus musculus	265-273
31332773-5	2020	We showed that CAP activation by neostigmine reduced the levels of pro-inflammatory cytokines (IL-4, IL-5, IL-13, IL-1beta, and TNF-alpha), which resulted in a decrease of eosinophils influx.	Neostigmine	33-44	interleukin 1 beta	Mus musculus	114-122
31453635-7	2020	Effects of IL-1beta on the development of embryo reduced in 20 ng/mL IL-1beta supplemented group when 5 mM 3-methyladenine (3-MA) was also added, which used to inhibit autophagy activation in endogenous PtdIns3Ks signal pathway.	3-methyladenine	124-128	interleukin 1 beta	Mus musculus	69-77
31820315-11	2020	Furthermore, tumor necrosis factor-alpha and interleukin-1beta were upregulated upon NaAsO2 treatment, suggesting the induction of inflammation.	Sodium	85-91	interleukin 1 beta	Mus musculus	45-62
31930778-10	2020	Additionally, AOAA attenuated NLRP3-Caspase1/IL-1beta activation and decreased the release of IL-6 and TNF-alpha pro-inflammatory cytokines and reciprocally increased IL-10 anti-inflammatory cytokine level in both ischaemic myocardium and M1 macrophages.	Aminooxyacetic Acid	14-18	interleukin 1 beta	Mus musculus	45-53
31930778-11	2020	In conclusion, short-term AOAA treatment significantly improves cardiac function in mice with MI by balancing macrophage polarization through modulating macrophage metabolism and inhibiting NLRP3-Caspase1/IL-1beta pathway.	Aminooxyacetic Acid	26-30	interleukin 1 beta	Mus musculus	205-213
31630319-12	2020	Co-administration of venlafaxine (40 mg/kg) with morphine not only inhibited the naloxone-precipitated withdrawal signs including jumping and weight loss, but also reduced the up-regulation of TNF-alpha, IL-1beta, IL-6, NO and MDA contents in mice brain tissue.	venlafaxine	21-32	interleukin 1 beta	Mus musculus	204-212
31630319-12	2020	Co-administration of venlafaxine (40 mg/kg) with morphine not only inhibited the naloxone-precipitated withdrawal signs including jumping and weight loss, but also reduced the up-regulation of TNF-alpha, IL-1beta, IL-6, NO and MDA contents in mice brain tissue.	Morphine	49-57	interleukin 1 beta	Mus musculus	204-212
31945013-8	2020	METHODS: The effects of metformin on cartilage degradation and chondrocyte aging was determined in a destabilization of the medial meniscus (DMM)-induced OA mouse model and in IL-1beta-treated mouse chondrocytes and cartilage explants.	Metformin	24-33	interleukin 1 beta	Mus musculus	176-184
31855808-4	2020	DHEA decreased the malondialdehyde content, superoxide dismutase activity and inducible nitric oxide synthase protein level; meanwhile, DHEA also inhibited the secretion of tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 in DSS-induced colitis mice.	Dehydroepiandrosterone	0-4	interleukin 1 beta	Mus musculus	202-219
31855808-4	2020	DHEA decreased the malondialdehyde content, superoxide dismutase activity and inducible nitric oxide synthase protein level; meanwhile, DHEA also inhibited the secretion of tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 in DSS-induced colitis mice.	Dehydroepiandrosterone	136-140	interleukin 1 beta	Mus musculus	202-219
31804693-5	2020	Intratracheal instillation of nZnO intensively aggravated LPS-induced lung inflammation that was accompanied by enhanced expression of interleukin-1beta, interleukin-6, monocyte chemotactic protein-1alpha, and granulocyte-macrophage colony stimulating factor.	nzno	30-34	interleukin 1 beta	Mus musculus	135-152
31887363-5	2020	Additionally, mice received teriflunomide had fewer activated Iba-1-positive microglia and lower protein levels of interleukin-1beta (IL-1beta), cyclooxygenase-2 (COX-2), and 3-Nitrotyrosine (3-NT) compared with those received vehicle on day 3.	teriflunomide	28-41	interleukin 1 beta	Mus musculus	115-132
31887363-5	2020	Additionally, mice received teriflunomide had fewer activated Iba-1-positive microglia and lower protein levels of interleukin-1beta (IL-1beta), cyclooxygenase-2 (COX-2), and 3-Nitrotyrosine (3-NT) compared with those received vehicle on day 3.	teriflunomide	28-41	interleukin 1 beta	Mus musculus	134-142
31916204-6	2020	Furthermore, edaravone significantly prevented the increase of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) induced by abdominal surgery in aged mice.	edaravone	13-22	interleukin 1 beta	Mus musculus	104-121
31916204-6	2020	Furthermore, edaravone significantly prevented the increase of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) induced by abdominal surgery in aged mice.	edaravone	13-22	interleukin 1 beta	Mus musculus	123-131
31825043-6	2020	Resveratrol was also able to prevent mouse body weight loss, reduce the disease activity index, attenuate tissue damage, and down-regulate the expression of pro-inflammatory cytokines such as IL-2, IFN-gamma, GM-CSF, IL-1beta, IL-6, KC/GRO, and TNF-alpha in the colon of DSS-treated mice.	resveratrol	0-11	interleukin 1 beta	Mus musculus	217-225
31931804-10	2020	RESULTS: In the present paper we showed how NAC supplementation affected parameters of oxidative stress (GSH, MDA, SOD), inflammation such as cytokines levels (IL-1beta, IL-6, TNFalpha) and mast cell activation and consequently on induced pain, during leishmaniosis in BALB\c mice.	Acetylcysteine	44-47	interleukin 1 beta	Mus musculus	160-168
32160757-7	2020	Al-ME downregulated mRNA expression of inflammatory genes (inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2)) and pro-inflammatory cytokines (tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6).	al-me	0-5	interleukin 1 beta	Mus musculus	191-208
31790652-3	2020	In murine microglial cell line BV-2 cells, pretreatment with dopamine for 24 h attenuated the lipopolysaccharide (LPS)-induced expression of proinflammatory cytokines such as tumor-necrosis factor-alpha, interleukin-1beta, and interleukin-6.	Dopamine	61-69	interleukin 1 beta	Mus musculus	204-221
31935983-6	2020	We found that myricetin significantly downregulated several markers of the neuroinflammatory response in LPS-induced activated microglia, including inducible nitric oxide (NO) synthase (iNOS), cyclooxygenase-2 (COX-2), and proinflammatory modulators and cytokines such as prostaglandin E2 (PGE2), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha).	myricetin	14-23	interleukin 1 beta	Mus musculus	297-314
31935983-6	2020	We found that myricetin significantly downregulated several markers of the neuroinflammatory response in LPS-induced activated microglia, including inducible nitric oxide (NO) synthase (iNOS), cyclooxygenase-2 (COX-2), and proinflammatory modulators and cytokines such as prostaglandin E2 (PGE2), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha).	myricetin	14-23	interleukin 1 beta	Mus musculus	316-324
31664855-4	2020	We found that lack of HO-1 activated lipopolysaccharide (LPS) and ATP-treated bone marrow-derived macrophages, causing an increase in secreted levels of cleaved interleukin (IL)-1B, IL-18, and caspase-1, markers of increased inflammasome activity, whereas HO-1 overexpression suppressed IL-1B, NLRP3, and IL-18.	Adenosine Triphosphate	66-69	interleukin 1 beta	Mus musculus	287-292
31664855-5	2020	The production of cleaved IL-1B and the activation of caspase-1 in LPS- and ATP-primed macrophages were inhibited by hemin, an HO-1 inducer, and two HO-1 enzymatic products [bilirubin and carbon monoxide (CO)].	Hemin	117-122	interleukin 1 beta	Mus musculus	26-31
31664855-5	2020	The production of cleaved IL-1B and the activation of caspase-1 in LPS- and ATP-primed macrophages were inhibited by hemin, an HO-1 inducer, and two HO-1 enzymatic products [bilirubin and carbon monoxide (CO)].	Bilirubin	174-183	interleukin 1 beta	Mus musculus	26-31
31766098-11	2020	DFSG and a mixture of caffeic acid, p-coumaric acid, and chlorogenic acid inhibited MUC5AC gene expression in A549 cells after stimulation with IL-1beta.	Caffeic Acids	22-34	interleukin 1 beta	Mus musculus	144-152
31664855-5	2020	The production of cleaved IL-1B and the activation of caspase-1 in LPS- and ATP-primed macrophages were inhibited by hemin, an HO-1 inducer, and two HO-1 enzymatic products [bilirubin and carbon monoxide (CO)].	Carbon Monoxide	188-203	interleukin 1 beta	Mus musculus	26-31
31664855-5	2020	The production of cleaved IL-1B and the activation of caspase-1 in LPS- and ATP-primed macrophages were inhibited by hemin, an HO-1 inducer, and two HO-1 enzymatic products [bilirubin and carbon monoxide (CO)].	Carbon Monoxide	205-207	interleukin 1 beta	Mus musculus	26-31
31810123-6	2020	The results indicated that hepatic histopathological changes induced by DSS were normalized by vitexin treatment, administration of vitexin decreased the liver levels of ALT and TC in mice with liver injury and reduced the release amounts of DSS-induced pro-inflammatory cytokines TNF-alpha, IL-6 and IL-1beta.	vitexin	132-139	interleukin 1 beta	Mus musculus	301-309
31634455-6	2020	Telmisartan not only inhibited AbetaO-induced proinflammatory interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha) expression, but also increased anti-inflammatory IL-10 expression, which was not affected by AbetaO stimulation.	telmisartan	0-11	interleukin 1 beta	Mus musculus	62-84
31670032-1	2020	Excessive release of interleukin-1beta (IL-1beta) is well-known to provoke cascades of inflammatory responses thus contributing to the pathogenesis of alcohol-induced steatohepatitis (ASH), but the cellular mechanism that regulates IL-1beta release during ASH remains unclear.	Ethanol	151-158	interleukin 1 beta	Mus musculus	21-38
31670032-1	2020	Excessive release of interleukin-1beta (IL-1beta) is well-known to provoke cascades of inflammatory responses thus contributing to the pathogenesis of alcohol-induced steatohepatitis (ASH), but the cellular mechanism that regulates IL-1beta release during ASH remains unclear.	Ethanol	151-158	interleukin 1 beta	Mus musculus	40-48
31670032-2	2020	Herein, we identified that gasdermin D (GSDMD) membrane pore is critical in mediating IL-1beta hypersecretion from chronic ethanol or acetaldehyde-stimulated macrophages.	Ethanol	123-130	interleukin 1 beta	Mus musculus	86-94
31670032-2	2020	Herein, we identified that gasdermin D (GSDMD) membrane pore is critical in mediating IL-1beta hypersecretion from chronic ethanol or acetaldehyde-stimulated macrophages.	Acetaldehyde	134-146	interleukin 1 beta	Mus musculus	86-94
31766098-11	2020	DFSG and a mixture of caffeic acid, p-coumaric acid, and chlorogenic acid inhibited MUC5AC gene expression in A549 cells after stimulation with IL-1beta.	p-coumaric acids	36-51	interleukin 1 beta	Mus musculus	144-152
31766098-11	2020	DFSG and a mixture of caffeic acid, p-coumaric acid, and chlorogenic acid inhibited MUC5AC gene expression in A549 cells after stimulation with IL-1beta.	Chlorogenic Acid	57-73	interleukin 1 beta	Mus musculus	144-152
31902360-12	2020	HCA had inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 beta, and IL-6.	alpha-hydroxycaprylic acid	0-3	interleukin 1 beta	Mus musculus	93-102
31676226-7	2020	We found that 8mg/kg DPN (ERbeta-specific agonist) replacement therapy (3 weeks) to the ovariectomized (OVX) mice significantly reduced ischemia injury and alleviated microglia and astrocyte activation, and markedly inhibited the expression of NF-kappaB and proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-6).	NAD	21-24	interleukin 1 beta	Mus musculus	296-304
31902360-12	2020	HCA had inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 beta, and IL-6.	Calcium Oxalate	30-45	interleukin 1 beta	Mus musculus	93-102
31914640-8	2020	More importantly, Rg3 can reduce IL-1beta secretion induced by LPS in mice and protect mice from lethal endotoxic shock.	ginsenoside Rg3	18-21	interleukin 1 beta	Mus musculus	33-41
31526985-6	2020	Glycyrrhizin reduced ROS levels at 6 months, and reduced levels of HMGB1, TNFalpha, and IL-1beta at both 2 and 6 months.	Glycyrrhizic Acid	0-12	interleukin 1 beta	Mus musculus	88-96
31539844-10	2020	RESULTS: In CLP mice, 6-gingerol significantly ameliorated sepsis development, which was associated with the reduction of serum IL-1beta.	gingerol	22-32	interleukin 1 beta	Mus musculus	128-136
31539844-11	2020	In BMDMs and RAW264.7 cells, 6-gingerol strongly attenuated pyroptosis as well as the release of caspase-1p20, HMGB1, mature IL-1beta, IL-18 in response to ATP and LPS treatment.	gingerol	29-39	interleukin 1 beta	Mus musculus	125-133
30207190-6	2020	Rotenone increased LDH release and IL-1beta levels in a dose-dependent manner (1-20 microM).	Rotenone	0-8	interleukin 1 beta	Mus musculus	35-43
30207190-7	2020	Luteolin inhibited rotenone-induced LDH release, however the activity decreased in concentration-dependent manner Neither rotenone nor luteolin altered TNF-alpha levels, but luteolin reduced IL-1beta levels in a concentration dependent manner in rotenone exposed cells.	Rotenone	19-27	interleukin 1 beta	Mus musculus	191-199
31680279-5	2020	The results showed that supplementation of STVRE with allopurinol significantly attenuated HU, oxidative stress, and inflammation caused by UA via inhibiting the production of uric acid and lowering cyclooxygenase-2, tumor necrosis factor-alpha, prostaglandin E2, interleukin-6, and interleukin 1-beta levels in serum and renal tissues.	Allopurinol	54-65	interleukin 1 beta	Mus musculus	283-301
31796384-4	2020	The further studies indicated that zileuton suppressed hippocampal neuroinflammation, evidenced by lower levels of TNF-alpha, IL-1beta and nuclear NF-kappaB p65 as well as decreased number of Iba1-positive cells.	zileuton	35-43	interleukin 1 beta	Mus musculus	126-134
31657123-5	2020	Glycyrrhizin decreased the plasma concentrations of HMGB1 and sRAGE as well as TNF-alpha, IL-1beta and IL-6 levels in the bronchoalveolar lavage fluid (BALF).	Glycyrrhizic Acid	0-12	interleukin 1 beta	Mus musculus	90-98
31812068-10	2020	Besides, SDG decreased the levels of inflammatory cytokines (IL-1beta, IL-18 and TNF-alpha) and inhibited the activation of the NLRP1 inflammasome in DSS-induced colitis mice and RAW264.7 mouse macrophages.	secoisolariciresinol diglucoside	9-12	interleukin 1 beta	Mus musculus	61-69
31332714-4	2020	Moreover, 3-NPA potentiated inflammatory status by enhancing the production of interleukin-1beta, tumor necrosis factor-alpha, and myeloperoxidase activity.	3-nitropropionic acid	10-15	interleukin 1 beta	Mus musculus	79-96
31704270-11	2020	These results indicate that cocaine induces alterations in CX3CL1 concentrations, which are associated with IL1beta concentrations, and activates convergent inflammatory pathways in the hippocampus.	Cocaine	28-35	interleukin 1 beta	Mus musculus	108-115
31466071-7	2020	Quantification of inflammatory mediators (IL-10, IL-4, IL-6, IL-1beta, and TNF-alpha) in the brain demonstrated that BbHA and BbMe effectively decreased the effect of LPS on the brain concentration of all measured cytokines.	bbha	117-121	interleukin 1 beta	Mus musculus	61-69
31466071-7	2020	Quantification of inflammatory mediators (IL-10, IL-4, IL-6, IL-1beta, and TNF-alpha) in the brain demonstrated that BbHA and BbMe effectively decreased the effect of LPS on the brain concentration of all measured cytokines.	bbme	126-130	interleukin 1 beta	Mus musculus	61-69
31704270-0	2020	Cocaine-induced changes in CX3CL1 and inflammatory signaling pathways in the hippocampus: Association with IL1beta.	Cocaine	0-7	interleukin 1 beta	Mus musculus	107-114
31704270-1	2020	Cocaine induces neuroinflammatory response and interleukin-1 beta (IL1beta) is suggested a final effector for many cocaine-induced inflammatory signals.	Cocaine	115-122	interleukin 1 beta	Mus musculus	47-65
31704270-1	2020	Cocaine induces neuroinflammatory response and interleukin-1 beta (IL1beta) is suggested a final effector for many cocaine-induced inflammatory signals.	Cocaine	115-122	interleukin 1 beta	Mus musculus	67-74
31704270-3	2020	This study is mainly focused on the characterization of CX3CL1, IL1beta and relevant inflammatory signal transduction pathways in the hippocampus in acute and repeated cocaine-treated male mice.	Cocaine	168-175	interleukin 1 beta	Mus musculus	64-71
31704270-6	2020	CX3CL1 and IL1beta concentrations were positively correlated in acute (r = +0.61) and repeated (r = +0.82) cocaine-treated mice.	Cocaine	107-114	interleukin 1 beta	Mus musculus	11-18
31298290-0	2020	Monosodium urate crystal interleukin-1beta release is dependent on Toll-like receptor 4 and transient receptor potential V1 activation.	Uric Acid	0-16	interleukin 1 beta	Mus musculus	25-42
31856083-8	2020	In addition, silymarin inhibited increased secretion of proinflammatory cytokines such as interleukin 1beta, interleukin 6, and tumor necrosis factor alpha.	Silymarin	13-22	interleukin 1 beta	Mus musculus	90-107
31618743-11	2020	Furthermore, after treated with ML204 or silenced the gene of TRPC5, the releases of TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-stimulated RAW264.7 cells were significantly increased.	ML 204	32-37	interleukin 1 beta	Mus musculus	96-104
31878270-4	2019	Treatment of lipopolysaccharide (LPS)-induced MC3T3-E1 cells with LF-NDs suppressed levels of pro-inflammatory cytokines, including interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	ITLN1 protein, human	66-68	interleukin 1 beta	Mus musculus	132-149
31888063-6	2019	Oral TPC treatment resulted in amelioration of the colitis clinical manifestations exemplified by reduced disease activity index (DAI) score, expansion of mesenteric lymph nodes (MLN) T regulatory cells (shown by Fluorescence Activated Cell Sorting (FACS)), significant reduction in the expression of pro-inflammatory cytokines (IL-1beta, IL17, IL-6, TNFalpha), and elevation in the expression of anti-inflammatory cytokine IL-10 (shown by RT-PCR).	Tuftsin	5-8	interleukin 1 beta	Mus musculus	329-337
31814281-5	2020	The decrease in mRNA and protein levels of NLRP3, Caspase-1, and IL-1beta is observed in dioscin treated mouse macrophages.	dioscin	89-96	interleukin 1 beta	Mus musculus	65-73
31892132-8	2019	beta-Caryophyllene prevented the ddC-induced increase in cytokine (interleukin 1 beta, tumor necrosis factor alpha and interferon gamma) transcripts in the paw skin and brain, as well as the phosphorylation level of Erk1/2 in the brain.	caryophyllene	0-18	interleukin 1 beta	Mus musculus	67-85
31892132-8	2019	beta-Caryophyllene prevented the ddC-induced increase in cytokine (interleukin 1 beta, tumor necrosis factor alpha and interferon gamma) transcripts in the paw skin and brain, as well as the phosphorylation level of Erk1/2 in the brain.	Zalcitabine	33-36	interleukin 1 beta	Mus musculus	67-85
31878270-4	2019	Treatment of lipopolysaccharide (LPS)-induced MC3T3-E1 cells with LF-NDs suppressed levels of pro-inflammatory cytokines, including interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	ITLN1 protein, human	66-68	interleukin 1 beta	Mus musculus	151-159
31873099-6	2019	Overexpression of Cav-1 suppressed bleomycin- or silica-induced activation of caspase-1 and maturation of pro-IL-1beta to secrete cleaved IL-1beta both in mouse lungs and in primary type I cells.	Bleomycin	35-44	interleukin 1 beta	Mus musculus	138-146
31873099-6	2019	Overexpression of Cav-1 suppressed bleomycin- or silica-induced activation of caspase-1 and maturation of pro-IL-1beta to secrete cleaved IL-1beta both in mouse lungs and in primary type I cells.	Silicon Dioxide	49-55	interleukin 1 beta	Mus musculus	110-118
31873099-6	2019	Overexpression of Cav-1 suppressed bleomycin- or silica-induced activation of caspase-1 and maturation of pro-IL-1beta to secrete cleaved IL-1beta both in mouse lungs and in primary type I cells.	Silicon Dioxide	49-55	interleukin 1 beta	Mus musculus	138-146
31937024-9	2019	ELISA showed that TNF-alpha, IL-6 and IL-1beta contents in the cell supernatant of the PQ group were significantly higher than those of 0 mumol/L PQ group, especially in 0.03 and 0.06 mumol/L PQ exposed group (P&lt;0.05) .	Paraquat	87-89	interleukin 1 beta	Mus musculus	38-46
31856816-7	2019	However, this effect was lower than 4 mug/mL of curcumin, which inhibited NO, IL-1beta and TNF-alpha production by 89.50 +- 5.00%, 78.80 +- 6.20% and 87.30 +- 4.00%, respectively.	Curcumin	48-56	interleukin 1 beta	Mus musculus	78-86
31937024-12	2019	Western blot showed that compared with 0 mumol/L PQ group, the expression levels of M1 markers TNF-alpha, IL-6, IL-1beta, iNOS and CD86 were significantly increased in 0.03 and 0.06 mumol/L PQ exposed group, while the expression levels of M2 markers Arg-1 and CD206 protein were decreased in 0.06 and 0.12 mumol/L PQ exposed group (P&lt;0.05) .	Paraquat	49-51	interleukin 1 beta	Mus musculus	112-120
31937024-12	2019	Western blot showed that compared with 0 mumol/L PQ group, the expression levels of M1 markers TNF-alpha, IL-6, IL-1beta, iNOS and CD86 were significantly increased in 0.03 and 0.06 mumol/L PQ exposed group, while the expression levels of M2 markers Arg-1 and CD206 protein were decreased in 0.06 and 0.12 mumol/L PQ exposed group (P&lt;0.05) .	Paraquat	190-192	interleukin 1 beta	Mus musculus	112-120
31937024-12	2019	Western blot showed that compared with 0 mumol/L PQ group, the expression levels of M1 markers TNF-alpha, IL-6, IL-1beta, iNOS and CD86 were significantly increased in 0.03 and 0.06 mumol/L PQ exposed group, while the expression levels of M2 markers Arg-1 and CD206 protein were decreased in 0.06 and 0.12 mumol/L PQ exposed group (P&lt;0.05) .	Paraquat	190-192	interleukin 1 beta	Mus musculus	112-120
31526918-5	2019	In addition, myricitrin decreased the production of pro-inflammatory factors including IL-1beta, IL-6 and TNFalpha, decreased the level of chemokine MCP-1, and suppressed the expressions of COX-2 and iNOS.	myricitrin	13-23	interleukin 1 beta	Mus musculus	87-95
31920554-10	2019	Furthermore, we verified the inhibitory effect of meisoindigo on TLR4/NF-kappaB signaling pathway, and found that meisoindigo treatment could significantly suppressed the expression of TLR4/NF-kappaB pathway-associated proteins in a dose-dependent manner, meanwhile, which resulted in downregulation of HMGB1 and IL-1beta.	N-methylisoindigotin	114-125	interleukin 1 beta	Mus musculus	313-321
31934279-7	2019	The results from the present study indicated that ALB dramatically suppressed the expression of inflammatory cytokines including IL-1beta, IL-6, and TNF-alpha, and inflammatory cells.	albiflorin	50-53	interleukin 1 beta	Mus musculus	129-137
31733211-5	2019	In cultured endothelial cells, nicotine caused Nlrp3 inflammasome complex formation and enhances the inflammasome activity as shown by increased cleavage of pro-caspase-1, and interleukin-1beta (IL-1beta) production.	Nicotine	31-39	interleukin 1 beta	Mus musculus	176-193
31733211-5	2019	In cultured endothelial cells, nicotine caused Nlrp3 inflammasome complex formation and enhances the inflammasome activity as shown by increased cleavage of pro-caspase-1, and interleukin-1beta (IL-1beta) production.	Nicotine	31-39	interleukin 1 beta	Mus musculus	195-203
31639401-8	2019	Furthermore, Saikosaponin-A administration strongly inhibited pro-inflammatory mediators (TNF-alpha, COX-2, IL-1beta and IL-6) and apoptotic markers (p-JNK, Casp-3).	saikosaponin D	13-27	interleukin 1 beta	Mus musculus	108-116
31849516-0	2019	NLRP3 Inflammasome Mediated Interleukin-1beta Production in Cancer-Associated Fibroblast Contributes to ALA-PDT for Cutaneous Squamous Cell Carcinoma.	1-phenyl-3,3-dimethyltriazene	104-111	interleukin 1 beta	Mus musculus	28-45
31849516-8	2019	Furthermore, NLRP3-inflammasome and p-p65/p65 were elevated after ALA-PDT mediated IL1beta production in cancer-associated-fibroblasts.	delta-aminolevulinic acid methyl ester	66-69	interleukin 1 beta	Mus musculus	83-90
31849504-9	2019	Histochemical analysis results showed significantly lower expression levels of ARAP1, AT1R, FN, NOX2, 8-OHdG, IL-1beta and IL-18 in renal tissues in the UA treatment group than in the DN group.	ursolic acid	153-155	interleukin 1 beta	Mus musculus	110-118
31849448-11	2019	In vitro, LPS-induced production of TNF-alpha and IL-6 and gene expression of TNF-alpha, IL-6, IL-1beta, and COX-2 could be inhibited by the pretreatment with C66 and SP600125.	T-66	159-162	interleukin 1 beta	Mus musculus	95-103
31849448-11	2019	In vitro, LPS-induced production of TNF-alpha and IL-6 and gene expression of TNF-alpha, IL-6, IL-1beta, and COX-2 could be inhibited by the pretreatment with C66 and SP600125.	pyrazolanthrone	167-175	interleukin 1 beta	Mus musculus	95-103
31849504-10	2019	Western blotting and RT-qPCR data also revealed UA-induced decreases in the renal levels of the ARAP1, AT1, NOX4, NOX2, TGF-beta1, FN, collagen IV, IL-1beta and IL-18 proteins in vivo and/or in vitro (p&lt;0.01).	ursolic acid	48-50	interleukin 1 beta	Mus musculus	148-156
31885501-7	2019	Administration of AUDA also reduced the LPS-induced changes of 14,15-DHET, IL-1beta, and IL-6 in the placentas of pregnant mice.	12-(3-adamantan-1-ylureido)dodecanoic acid	18-22	interleukin 1 beta	Mus musculus	75-83
31817854-4	2019	We demonstrate through both approaches that IL-1beta and ethanol"s modulatory effects at CeA GABA synapses are not dependent on MyD88.	gamma-Aminobutyric Acid	93-97	interleukin 1 beta	Mus musculus	44-52
31817854-6	2019	Pharmacological inhibition of MyD88 modulates IL-1beta"s action at CeA GABA synapses similar to Myd88 knockout mice.	gamma-Aminobutyric Acid	71-75	interleukin 1 beta	Mus musculus	46-54
31419499-6	2019	RESULTS: Vp-ME inhibited NO production in RAW264.7 cells stimulated with pam3CSK4, poly I:C or LPS and in LPS-stimulated peritoneal macrophages without cytotoxicity and downregulated mRNA expression of inflammatory enzymes, inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) and pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6.	vp-me	9-14	interleukin 1 beta	Mus musculus	355-372
31419499-6	2019	RESULTS: Vp-ME inhibited NO production in RAW264.7 cells stimulated with pam3CSK4, poly I:C or LPS and in LPS-stimulated peritoneal macrophages without cytotoxicity and downregulated mRNA expression of inflammatory enzymes, inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) and pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6.	vp-me	9-14	interleukin 1 beta	Mus musculus	374-382
31792327-9	2019	SAL down-regulated the expression levels of TNF-alpha, TGF-beta1, IL-1beta, Bax and up-regulate the expression of Bcl-2, VEGF, Akt and eNOS.	rhodioloside	0-3	interleukin 1 beta	Mus musculus	66-74
31793343-3	2021	As the incubation time increased, MeHgCl had obvious damage to cell morphology, decreased the ratio of Bcl-2 and Bak and increased the expressions of TNF-alpha, IL-6 and IL-1beta significantly.	Mercuric Chloride	34-40	interleukin 1 beta	Mus musculus	170-178
31793343-4	2021	Furthermore, the expressions of IL-1beta and IL-6 in HgCl2 group were increased significantly in 6 h and 24 h. The apoptotic rates in MeHgCl and HgCl2 group were respectively higher than beta-HgS with 32.2% and 7.30% in 24 h. Our findings indicate that beta-HgS is much less neurotoxicity than MeHgCl and HgCl2 in Neuro-2a cells.	Mercuric Chloride	53-58	interleukin 1 beta	Mus musculus	32-40
31793343-4	2021	Furthermore, the expressions of IL-1beta and IL-6 in HgCl2 group were increased significantly in 6 h and 24 h. The apoptotic rates in MeHgCl and HgCl2 group were respectively higher than beta-HgS with 32.2% and 7.30% in 24 h. Our findings indicate that beta-HgS is much less neurotoxicity than MeHgCl and HgCl2 in Neuro-2a cells.	Mercuric Chloride	134-140	interleukin 1 beta	Mus musculus	32-40
31793343-4	2021	Furthermore, the expressions of IL-1beta and IL-6 in HgCl2 group were increased significantly in 6 h and 24 h. The apoptotic rates in MeHgCl and HgCl2 group were respectively higher than beta-HgS with 32.2% and 7.30% in 24 h. Our findings indicate that beta-HgS is much less neurotoxicity than MeHgCl and HgCl2 in Neuro-2a cells.	Mercuric Chloride	145-150	interleukin 1 beta	Mus musculus	32-40
31793343-4	2021	Furthermore, the expressions of IL-1beta and IL-6 in HgCl2 group were increased significantly in 6 h and 24 h. The apoptotic rates in MeHgCl and HgCl2 group were respectively higher than beta-HgS with 32.2% and 7.30% in 24 h. Our findings indicate that beta-HgS is much less neurotoxicity than MeHgCl and HgCl2 in Neuro-2a cells.	Mercury	192-195	interleukin 1 beta	Mus musculus	32-40
31793343-4	2021	Furthermore, the expressions of IL-1beta and IL-6 in HgCl2 group were increased significantly in 6 h and 24 h. The apoptotic rates in MeHgCl and HgCl2 group were respectively higher than beta-HgS with 32.2% and 7.30% in 24 h. Our findings indicate that beta-HgS is much less neurotoxicity than MeHgCl and HgCl2 in Neuro-2a cells.	Mercury	258-261	interleukin 1 beta	Mus musculus	32-40
31793343-4	2021	Furthermore, the expressions of IL-1beta and IL-6 in HgCl2 group were increased significantly in 6 h and 24 h. The apoptotic rates in MeHgCl and HgCl2 group were respectively higher than beta-HgS with 32.2% and 7.30% in 24 h. Our findings indicate that beta-HgS is much less neurotoxicity than MeHgCl and HgCl2 in Neuro-2a cells.	Mercuric Chloride	294-300	interleukin 1 beta	Mus musculus	32-40
31793343-4	2021	Furthermore, the expressions of IL-1beta and IL-6 in HgCl2 group were increased significantly in 6 h and 24 h. The apoptotic rates in MeHgCl and HgCl2 group were respectively higher than beta-HgS with 32.2% and 7.30% in 24 h. Our findings indicate that beta-HgS is much less neurotoxicity than MeHgCl and HgCl2 in Neuro-2a cells.	Mercuric Chloride	145-150	interleukin 1 beta	Mus musculus	32-40
31849652-7	2019	Simultaneously, Sal alleviated excessive inflammation by reversing the IL-1beta, TNF-alpha, and IL-10 protein levels in DSS-treated mice.	rhodioloside	16-19	interleukin 1 beta	Mus musculus	71-79
31849652-7	2019	Simultaneously, Sal alleviated excessive inflammation by reversing the IL-1beta, TNF-alpha, and IL-10 protein levels in DSS-treated mice.	Dextran Sulfate	120-123	interleukin 1 beta	Mus musculus	71-79
31677073-9	2019	Notably, in vivo data indicate that CBZ (50 mg/kg) causes liver injury in an LPS (2 mg/kg)-mediated susceptibility mouse model of IDILI, accompanied by an increase in caspase-1 activity and IL-1beta production, whereas the combination of CBZ and LPS does not exhibit the effect in NLRP3-knockout mice.	Carbamazepine	36-39	interleukin 1 beta	Mus musculus	190-198
31571510-5	2019	Taraxasterol also significantly inhibited the release of pro-inflammatory cytokines tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), IL-1beta, interferon-gamma (IFN-gamma) and IL-4.	taraxasterol	0-12	interleukin 1 beta	Mus musculus	148-156
31568781-8	2019	We found that: nalbuphine (a) antagonized scratching in a dose- and time-dependent manner without affecting locomotion, b) decreased IL-31, and increased anti-inflammatory IL-10, and c) induced more elevations in the levels of CCL2, CCL3, CCL12, CXCL1, CXCL2, CXCL9, CXCL10, IL-1beta, IL-16, TIMP-1, M-CSF, TREM-1 and M1-type macrophages compared to saline.	Nalbuphine	15-25	interleukin 1 beta	Mus musculus	275-283
31647995-6	2019	We also observed the expression of exosome markers such as CD63 and alkaline phosphatase (ALP) was augmented in STZ-treated Asah1fl/fl/ECcre mice compared to WT/WT mice, which was accompanied by an increased IL-1beta release of exosomes.	Streptozocin	112-115	interleukin 1 beta	Mus musculus	208-216
31647995-8	2019	The CECs from Asah1fl/fl/ECcre mice had decreased MVB-lysosome interaction and increased IL-1beta-containing exosome release in response to high glucose stimulation.	Glucose	145-152	interleukin 1 beta	Mus musculus	89-97
31586906-10	2019	We found that GAAS down-regulated the mRNA expression of IL-1beta, IL-6, TNF-alpha, IFN-gamma, and IL-17A, and it up-regulated the mRNA expression of IL-4 and TGF-beta.	Glycyrrhizic Acid	14-18	interleukin 1 beta	Mus musculus	57-65
31356994-7	2019	NaF-inactivated TLR2/MyD88 signaling pathway was identified by prominently downregulated mRNA and protein expression levels of TLR2/MyD88, IRAK4, IRAK1, TRAF6, TAK1, MKK4/MKK7 and c-Jun, which ultimately altered the expression levels of IL-1beta, IL-4, IL-6 and IL-8 to attenuate innate immunity.	Sodium Fluoride	0-3	interleukin 1 beta	Mus musculus	237-245
31309485-3	2019	Oral paeoniflorin treatment also downregulated the systemic pro-inflammatory cytokines IL-6 (by 52.2%), TNF-alpha (by 57.7%) and IL-1beta (by 34.1%).	peoniflorin	5-17	interleukin 1 beta	Mus musculus	129-137
31798708-7	2019	Additionally, inflammatory cytokines TNF-alpha, IL-6 and IL-1beta expression were also significantly reduced in mice with OV treatment.	vanillin	122-124	interleukin 1 beta	Mus musculus	57-65
31366457-7	2019	Knockdown of ZEB1 in CRC cells inhibited 8-oxo-dG induction by oxidative stress (H2O2) and inflammatory cytokines (interleukin (IL)1beta).	8-ohdg	41-49	interleukin 1 beta	Mus musculus	115-136
31321583-5	2019	Pretreatment with AZD4547 significantly alleviated the expression of the pro-inflammatory factors IL-1beta, IL-6, TNF-alpha, MMP9, and CXCL10 both in vivo and in vitro.	AZD4547	18-25	interleukin 1 beta	Mus musculus	98-106
31522340-5	2019	alpha7nAchR agonist PNU-282987 protected MH-S cells from LPS-induced inflammation by reducing the concentrations of IL-6, TNF-alpha, and IL-1beta.	N-neopentyl-N-nitrosourea	20-23	interleukin 1 beta	Mus musculus	137-145
31677497-6	2019	In addition, EP decreased microglia enrichment in myelin sheath, and declined TLR4/p-NF-kb/p65 and IL-1beta and IL-6, inhibiting microglia-mediated neuroinflammation.	ethyl pyruvate	13-15	interleukin 1 beta	Mus musculus	99-107
31678864-5	2019	Further, DMI significantly inhibited the toxic conversion of the peri-infarct microglia, and decreased the protein level of interleukin 1beta.	dimethyl itaconate	9-12	interleukin 1 beta	Mus musculus	124-141
31699670-4	2019	Exposure of BV2 cells to BaP (10 muM) significantly increased DNA damage and the production of pro-inflammatory mediators, including nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), malondialdehyde (MDA), and cytokines (interleukins-1beta and -6).	Benzo(a)pyrene	25-28	interleukin 1 beta	Mus musculus	287-312
31699670-5	2019	On the other hand, when BaP-treated BV2 cells were further incubated with FA (10, 20, 40, or 80 mg/mL) for another 24 h, a significant reduction in BaP-induced DNA damage and the release of multiple pro-inflammatory and cytotoxic factors (including interleukin-1beta, interleukin-6, NO, and ROS) was observed in a dose-dependent manner.	Benzo(a)pyrene	24-27	interleukin 1 beta	Mus musculus	249-266
31452288-7	2019	Not only that, quercetin markedly attenuated T2DM-induced production of interleukin 1 beta, interleukin 6, and TNF-alpha.	Quercetin	15-24	interleukin 1 beta	Mus musculus	72-90
30924005-11	2019	In this regards, we found that trigonelline decreased the MDA level, attenuated the expression of Tnf-alpha, Il/1beta and, Tlr4 as well as modulated the histopathological alterations in the intestine.	trigonelline	31-43	interleukin 1 beta	Mus musculus	109-117
31661120-12	2019	In addition, the activation of glia cells and upregulation of the glia-derived inflammatory mediators, interleukin (IL)-1beta and IL-6 were suppressed by JWH015.	JHW 015	154-160	interleukin 1 beta	Mus musculus	103-125
31661120-13	2019	In LPS-stimulated primary neurons, IL-1beta and IL-6 were increased, and autophagy flux was impaired; whereas treatment with JWH015 decreased the expression of IL-1beta and IL-6, LC3B-II/LC3B-I ratio and expression of p62.	JHW 015	125-131	interleukin 1 beta	Mus musculus	160-168
31661120-16	2019	Intrathecal administration of the selective CB2 agonist JWH015 ameliorated autophagy flux through the downregulation of IL-1beta and IL-6 and attenuated BCP.	JHW 015	56-62	interleukin 1 beta	Mus musculus	120-128
30612217-8	2019	Naringenin also inhibited inflammasome upregulation (reduced Nlrp3, ASC, caspase-1, and pro-IL-1beta mRNA expression) and oxidative stress (reduced gp91phox mRNA expression and superoxide anion production, increased GSH levels, induced Nrf2 protein in CD45+ hematopoietic recruited cells, and induced Nrf2 and HO-1 mRNA expression).	naringenin	0-10	interleukin 1 beta	Mus musculus	92-100
31605760-12	2019	SB also suppressed LPS-induced MPO activity and the production of inflammatory cytokines TNF-alpha and IL-1beta.	Butyric Acid	0-2	interleukin 1 beta	Mus musculus	103-111
31626919-9	2019	Mechanistically, miR-124 directly targeted signal transducer and activator of transcription 3 (STAT3) in BV2 cells; in addition, upregulation of miR-124 inhibited the increase of inducible nitric oxide synthetase and proinflammatory cytokines, including IL-6, IL-1beta, TNF-alpha, and MCP-1, in LPS-stimulated BV2 cells.	Nitric Oxide	189-201	interleukin 1 beta	Mus musculus	260-268
31633177-0	2019	Prostaglandin-E2 deficiency during late pregnancy and the associated increase in interleukin-1beta derived from periaortic lymph nodes lead to abortion.	Dinoprostone	0-16	interleukin 1 beta	Mus musculus	81-98
31633177-5	2019	Further, through RNA sequencing, we reveal that PLNs produce a large amount of interleukin-1beta (IL-1beta) when exposed to PGE2 deficiency, which causes damage to the placental labyrinth, probably via destroying the extracellular matrix.	Dinoprostone	124-128	interleukin 1 beta	Mus musculus	79-96
31633177-5	2019	Further, through RNA sequencing, we reveal that PLNs produce a large amount of interleukin-1beta (IL-1beta) when exposed to PGE2 deficiency, which causes damage to the placental labyrinth, probably via destroying the extracellular matrix.	Dinoprostone	124-128	interleukin 1 beta	Mus musculus	98-106
31633177-7	2019	These results suggest that high levels of PGE2 during late pregnancy protect fetuses from inflammatory damage related to IL-1beta.	Dinoprostone	42-46	interleukin 1 beta	Mus musculus	121-129
31586460-8	2019	Our result also showed that chronic corticosterone treatment increased procaspase-1 cleavage, caspase-1 activity and interleukin-1beta release in N9 microglia.	Corticosterone	36-50	interleukin 1 beta	Mus musculus	117-134
31586460-10	2019	Our results suggest that chronic corticosterone treatment upregulates Txnip and increases Txnip-NLRP3 binding, which activates NLRP3 inflammasome, resulting in activation of caspase-1 and in further releasing of interleukin-1beta.	Corticosterone	33-47	interleukin 1 beta	Mus musculus	212-229
31805689-9	2019	Syb-prII-1 markedly suppressed the expression of IL-1beta, IL-6, and TNF-alpha of mice in formalin-induced inflammatory nociception.	Formaldehyde	90-98	interleukin 1 beta	Mus musculus	49-57
31669149-7	2019	Downregulation of Mtdh obviously inhibited nuclear factor-kappaB signaling activation and suppressed its downstream inflammatory cytokines, such as monocyte chemotactic peptide-1, interleukin-1beta, tumor necrosis factor-alpha, and interleukin-6 in HG-induced mTECs, which was similar to the effect of MCL.	micheliolide	302-305	interleukin 1 beta	Mus musculus	180-226
31784933-10	2021	Compared with the model group, fluoxetine and geniposide + eleutheroside B administration significantly improved the immobility time of depressed mice in the FST and TST, decreased serum IL-1 beta content, inhibited the expression levels of NF- kappa B gene and protein in hippocampus tissues (P&lt;0.05 or P&lt;0.01).	Fluoxetine	31-41	interleukin 1 beta	Mus musculus	187-196
31784933-10	2021	Compared with the model group, fluoxetine and geniposide + eleutheroside B administration significantly improved the immobility time of depressed mice in the FST and TST, decreased serum IL-1 beta content, inhibited the expression levels of NF- kappa B gene and protein in hippocampus tissues (P&lt;0.05 or P&lt;0.01).	geniposide	46-56	interleukin 1 beta	Mus musculus	187-196
31849616-8	2019	Both inhibitors blunted LPA-induced phosphorylation of STAT1 and STAT3, p65, and c-Jun and consequently reduced the secretion of pro-inflammatory cyto-/chemokines (IL-6, TNFalpha, IL-1beta, CXCL10, CXCL2, and CCL5) at non-toxic concentrations.	lysophosphatidic acid	24-27	interleukin 1 beta	Mus musculus	180-188
31784933-10	2021	Compared with the model group, fluoxetine and geniposide + eleutheroside B administration significantly improved the immobility time of depressed mice in the FST and TST, decreased serum IL-1 beta content, inhibited the expression levels of NF- kappa B gene and protein in hippocampus tissues (P&lt;0.05 or P&lt;0.01).	syringin	59-74	interleukin 1 beta	Mus musculus	187-196
31771272-11	2019	The cytokines IL-1beta, IL-6 and KC/GRO were increased in mdx plasma and diaphragm compared with wild type; NAC decreased systemic IL-1beta and KC/GRO concentrations in mdx mice.	Acetylcysteine	108-111	interleukin 1 beta	Mus musculus	131-139
31775224-7	2019	OIR3 was able to reduce oxazolone-induced skin inflammation in allergic dermatitis mouse model via the inhibition of TNF-alpha, IL-1beta and IL-6 mRNA expression.	Oxazolone	24-33	interleukin 1 beta	Mus musculus	128-136
31611307-7	2019	N-acetyl-L-cysteine and mito-TEMPO blocked the induction of IL-1beta by inhibiting reactive oxygen species (ROS) with SAA treatment.	Acetylcysteine	0-19	interleukin 1 beta	Mus musculus	60-68
31657406-5	2019	When using the microglial BV2 cells to investigate the underlying mechanisms, we found that the NLRP3 inflammasome activation was involved in the IL-1beta-mediated inflammation induced by Ag2Se QDs.	Silver	188-193	interleukin 1 beta	Mus musculus	146-154
31611307-7	2019	N-acetyl-L-cysteine and mito-TEMPO blocked the induction of IL-1beta by inhibiting reactive oxygen species (ROS) with SAA treatment.	TEMPO	29-34	interleukin 1 beta	Mus musculus	60-68
31611307-7	2019	N-acetyl-L-cysteine and mito-TEMPO blocked the induction of IL-1beta by inhibiting reactive oxygen species (ROS) with SAA treatment.	Oxygen	92-98	interleukin 1 beta	Mus musculus	60-68
31827682-5	2019	DBA induced inflammation in the liver of the mice which is supported by increasing the production of tumor necrosis factor-alpha (TNF-alpha) and the mRNA levels of TNF-alpha, interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and nuclear factor kappaB (NF-kappaB) in the liver.	dibromoacetic acid	0-3	interleukin 1 beta	Mus musculus	197-214
31814910-14	2019	Meanwhile, AS II decreased the levels of IL-6, TNF-alpha, IL-1beta, NO, MPO and MDA, and increased the level of SOD in colon of DSS-treated mice.	astragaloside II	11-16	interleukin 1 beta	Mus musculus	58-66
31827682-5	2019	DBA induced inflammation in the liver of the mice which is supported by increasing the production of tumor necrosis factor-alpha (TNF-alpha) and the mRNA levels of TNF-alpha, interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and nuclear factor kappaB (NF-kappaB) in the liver.	dibromoacetic acid	0-3	interleukin 1 beta	Mus musculus	216-224
31803045-10	2019	Melatonin and rapamycin significantly ameliorated the isoflurane-induced cognitive impairment and also led to a decrease in the melatonin levels as well as the expression levels of TNF-alpha, IL-1beta, IL-6, and p-mTOR in the hippocampus.	Melatonin	0-9	interleukin 1 beta	Mus musculus	192-200
31803045-10	2019	Melatonin and rapamycin significantly ameliorated the isoflurane-induced cognitive impairment and also led to a decrease in the melatonin levels as well as the expression levels of TNF-alpha, IL-1beta, IL-6, and p-mTOR in the hippocampus.	Sirolimus	14-23	interleukin 1 beta	Mus musculus	192-200
31539551-12	2019	LASSBio-596 also decreased gastric TNF-alpha and interleukin-1beta (IL-1beta) protein levels, MPO enzymatic activity, and hemoglobin levels.	LASSBIO596	0-11	interleukin 1 beta	Mus musculus	49-66
31539551-12	2019	LASSBio-596 also decreased gastric TNF-alpha and interleukin-1beta (IL-1beta) protein levels, MPO enzymatic activity, and hemoglobin levels.	LASSBIO596	0-11	interleukin 1 beta	Mus musculus	68-76
31610190-9	2019	Additionally, VGX-1027 treatment resulted in a substantial decrease in IL-1beta, IL-6, TNF-alpha, IFN-gamma, and NF-kappaB p65 production, but increased IL-10 production in CD4+ T cells.	3-phenyl-4,5-dihydro-5-isoxazole acetic acid	14-22	interleukin 1 beta	Mus musculus	71-79
31803174-3	2019	MSU crystals engage the Nlrp3 inflammasome, leading to the activation of caspase-1 and production of IL-1beta and IL-18 within gout-affected joints, promoting the influx of neutrophils and monocytes.	Uric Acid	0-3	interleukin 1 beta	Mus musculus	101-109
31127937-6	2019	We found that ibuprofen-treated mouse models presented a significant reduction in the neuroinflammation markers, namely Il1b and TNFa mRNA and IKB-alpha protein phosphorylation levels.	Ibuprofen	14-23	interleukin 1 beta	Mus musculus	120-124
31709625-10	2019	Under inflammatory microenvironment, rosiglitazone not only suppressed the expression of interleukin-1beta caused by TNF-alpha, but improved the expression of mineralization genes in OCCM-30 cells.	rosiglitazonermsf	37-50	interleukin 1 beta	Mus musculus	89-106
31788011-12	2019	In addition, the mRNA expression of hepatic tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) as well as the plasma levels of TNF-alpha and IL-1beta were also lowered by curcumin treatment.	Curcumin	194-202	interleukin 1 beta	Mus musculus	89-106
31788011-12	2019	In addition, the mRNA expression of hepatic tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) as well as the plasma levels of TNF-alpha and IL-1beta were also lowered by curcumin treatment.	Curcumin	194-202	interleukin 1 beta	Mus musculus	164-172
31815123-10	2019	For example, TLR4 activation by LPS is noted to release proinflammatory cytokines, IL-1beta, from microglia that subsequently suppresses GABA receptor activities at the postsynaptic site and reduces GABA synthesis at the presynaptic site.	gamma-Aminobutyric Acid	137-141	interleukin 1 beta	Mus musculus	83-91
31815123-10	2019	For example, TLR4 activation by LPS is noted to release proinflammatory cytokines, IL-1beta, from microglia that subsequently suppresses GABA receptor activities at the postsynaptic site and reduces GABA synthesis at the presynaptic site.	gamma-Aminobutyric Acid	199-203	interleukin 1 beta	Mus musculus	83-91
31610207-5	2019	The optimal dose of BCP, 72 mg/kg body weight, inhibited microglial activation and reduced the secretion of proinflammatory cytokines interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6 by microglia of WT mice.	caryophyllene	20-23	interleukin 1 beta	Mus musculus	134-156
31700106-13	2019	LPS + ATP increased NLRP3, caspase-1 and interleukin-1beta (IL-1beta).	Adenosine Triphosphate	6-9	interleukin 1 beta	Mus musculus	41-58
31700106-13	2019	LPS + ATP increased NLRP3, caspase-1 and interleukin-1beta (IL-1beta).	Adenosine Triphosphate	6-9	interleukin 1 beta	Mus musculus	60-68
29735977-8	2019	Exogenous administration of N-Acetyl-L-cysteine (NAC), a small molecular inhibitor of ROS, remarkably suppressed caspase-1 p20 expression and IL-1beta and IL-18 production in livers of Tim-3 KO mice, thus significantly reducing the severity of steatohepatitis induced by MCD.	Acetylcysteine	28-47	interleukin 1 beta	Mus musculus	142-150
31780865-8	2019	Results: Rubiadin-1-methyl ether was able to inhibit the pro-inflammatory parameters studied in the in vitro assays (NOx, IL-6, and IL-1beta) and, at the same time, increased the macrophage apoptosis rate.	rubiadin 1-methyl ether	9-32	interleukin 1 beta	Mus musculus	132-140
31493747-5	2019	The cytokines, including TNF-alpha, IL-1beta, IL-6, and IL-17 in psoriasiform skin, can be attenuated to normal baseline by CIM.	cim	124-127	interleukin 1 beta	Mus musculus	36-44
31493747-10	2019	CIM inhibited the overexpression of IL-1beta, IL-6, and IL-24 in HaCaT.	cim	0-3	interleukin 1 beta	Mus musculus	36-44
29735977-8	2019	Exogenous administration of N-Acetyl-L-cysteine (NAC), a small molecular inhibitor of ROS, remarkably suppressed caspase-1 p20 expression and IL-1beta and IL-18 production in livers of Tim-3 KO mice, thus significantly reducing the severity of steatohepatitis induced by MCD.	Acetylcysteine	49-52	interleukin 1 beta	Mus musculus	142-150
31611942-4	2019	In addition, treatment with Nec-1 significantly decreased the number of lesions and inflammatory cell infiltrates in spinal cord tissues, as well as the production of associated pro-inflammatory cytokines, including tumor necrosis factor alpha (TNFalpha), interferon-gamma and interleukin-1beta.	necrostatin-1	28-33	interleukin 1 beta	Mus musculus	277-294
31762728-13	2019	Curcumin also attenuated inflammation by inhibiting the IkappaBalpha-NF-kappaB pathway, which reduced the production of TNF, IL-1beta, and IL-6.	Curcumin	0-8	interleukin 1 beta	Mus musculus	125-133
31419475-6	2019	Importantly, TCE exposure resulted in the activation of hepatic inflammasome (NLRP3 and caspase-1) and up-regulation of pro-inflammatory cytokine IL-1beta, and these changes were attenuated by NAC supplementation.	Trichloroethylene	13-16	interleukin 1 beta	Mus musculus	146-154
31419475-6	2019	Importantly, TCE exposure resulted in the activation of hepatic inflammasome (NLRP3 and caspase-1) and up-regulation of pro-inflammatory cytokine IL-1beta, and these changes were attenuated by NAC supplementation.	Acetylcysteine	193-196	interleukin 1 beta	Mus musculus	146-154
31374322-6	2019	In liver tissue, treatment with torularhodin increased ethanol-induced superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels and decreased tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) levels.	torularhodin	32-44	interleukin 1 beta	Mus musculus	199-216
31374322-6	2019	In liver tissue, treatment with torularhodin increased ethanol-induced superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels and decreased tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) levels.	torularhodin	32-44	interleukin 1 beta	Mus musculus	218-226
31374322-6	2019	In liver tissue, treatment with torularhodin increased ethanol-induced superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels and decreased tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) levels.	Ethanol	55-62	interleukin 1 beta	Mus musculus	199-216
31374322-6	2019	In liver tissue, treatment with torularhodin increased ethanol-induced superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels and decreased tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) levels.	Ethanol	55-62	interleukin 1 beta	Mus musculus	218-226
31478196-6	2019	Treatment with CT enhanced the production of interleukin-1beta (IL-1beta), but not tumor necrosis factor-alpha or IL-12p40, induced by stimulation of dendritic cells with muramyl dipeptide, the Nod2 ligand.	Acetylmuramyl-Alanyl-Isoglutamine	171-188	interleukin 1 beta	Mus musculus	45-62
31478196-6	2019	Treatment with CT enhanced the production of interleukin-1beta (IL-1beta), but not tumor necrosis factor-alpha or IL-12p40, induced by stimulation of dendritic cells with muramyl dipeptide, the Nod2 ligand.	Acetylmuramyl-Alanyl-Isoglutamine	171-188	interleukin 1 beta	Mus musculus	64-72
31478196-7	2019	Mechanistically, the enhanced production of IL-1beta induced by muramyl dipeptide and CT stimulation required Nod2 and was mediated by both increased synthesis of pro-IL-1beta and caspase-1 activation.	Dipeptides	72-81	interleukin 1 beta	Mus musculus	44-52
31478196-7	2019	Mechanistically, the enhanced production of IL-1beta induced by muramyl dipeptide and CT stimulation required Nod2 and was mediated by both increased synthesis of pro-IL-1beta and caspase-1 activation.	Dipeptides	72-81	interleukin 1 beta	Mus musculus	167-175
31737627-6	2019	This D-ribose-induced NLRP3 inflammasome formation was accompanied by its activation as evidenced by increased IL-1beta production, a major product of NLRP3 inflammasome.	Ribose	5-13	interleukin 1 beta	Mus musculus	111-119
31425341-4	2019	Two hours after the administration, inhalation of sevoflurane significantly reduced the serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-10 (P &lt; 0.05).	Sevoflurane	50-61	interleukin 1 beta	Mus musculus	145-167
31425341-7	2019	The inhalation of sevoflurane inhibited increases in myeloperoxidase (MPO), macrophage inflammatory protein-2 (MIP-2), TNF-alpha and IL-1beta levels (P &lt; 0.05) induced by endotoxemia, whereas IL-6 release was facilitated.	Sevoflurane	18-29	interleukin 1 beta	Mus musculus	133-141
31683684-4	2019	The data showed that the different ratios of BA and MS had different degrees of inhibition of interleukin-1beta (IL-1beta), IL-6, and inducible nitric oxide synthase (iNOS) mRNA expression, down-regulated the phosphor-nuclear factor kappa B/nuclear factor kappa B (p-NF-kB)/(NF-kB), phosphorylated protein kinase b/protein kinase b (p-AKT/AKT), and Toll-like receptor 4 (TLR4) protein expression levels, and increased phospho-PI3 kinase (p-PI3K) protein expression levels.	boswellic acid	45-47	interleukin 1 beta	Mus musculus	94-111
31683684-4	2019	The data showed that the different ratios of BA and MS had different degrees of inhibition of interleukin-1beta (IL-1beta), IL-6, and inducible nitric oxide synthase (iNOS) mRNA expression, down-regulated the phosphor-nuclear factor kappa B/nuclear factor kappa B (p-NF-kB)/(NF-kB), phosphorylated protein kinase b/protein kinase b (p-AKT/AKT), and Toll-like receptor 4 (TLR4) protein expression levels, and increased phospho-PI3 kinase (p-PI3K) protein expression levels.	boswellic acid	45-47	interleukin 1 beta	Mus musculus	113-121
31290458-11	2019	Atsttrin treatment reduced the lipopolysaccharide-induced increase in the protein and mRNA levels of tumor necrosis factor-alpha, interleukin-1beta, matrix metalloproteinase-3 and inducible nitric oxide synthase in the brain of progranulin knockout mice.	atsttrin	0-8	interleukin 1 beta	Mus musculus	130-211
31290458-12	2019	Atsttrin also reduced the expression of cyclooxygenase-2, inducible nitric oxide synthase and matrix metalloproteinase 3 mRNA in lipopolysaccharide-treated astrocytes in vitro, and decreased the concentration of tumor necrosis factor a and interleukin-1beta in the supernatant.	atsttrin	0-8	interleukin 1 beta	Mus musculus	240-257
31656063-4	2019	In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice, oral administration of KMS99220 attenuated microglial activation and decreased the levels of inducible nitric oxide synthase and interleukin 1 beta (IL-1b) in the nigrostriatal system.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	3-47	interleukin 1 beta	Mus musculus	211-216
31656063-4	2019	In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice, oral administration of KMS99220 attenuated microglial activation and decreased the levels of inducible nitric oxide synthase and interleukin 1 beta (IL-1b) in the nigrostriatal system.	KMS4034	85-93	interleukin 1 beta	Mus musculus	191-209
31656063-4	2019	In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice, oral administration of KMS99220 attenuated microglial activation and decreased the levels of inducible nitric oxide synthase and interleukin 1 beta (IL-1b) in the nigrostriatal system.	KMS4034	85-93	interleukin 1 beta	Mus musculus	211-216
31656063-5	2019	In lipopolysaccharide (LPS)-challenged BV-2 microglial cells, KMS99220 suppressed the production and expression of IL-1b.	KMS4034	62-70	interleukin 1 beta	Mus musculus	115-120
31737627-11	2019	Mechanically, AGEs formation inhibition and cleavage or silencing of RAGE gene were shown to suppress D-ribose-induced NLRP3 inflammasome formation and activation, as shown by significant reduction of NLRP3 inflammasome molecular aggregation, caspase-1 activity and IL-1beta production.	Ribose	102-110	interleukin 1 beta	Mus musculus	266-274
31323300-10	2019	A total of 12 beta-carboline alkaloids were identified in Part1 and they all showed suppressive effect on inflammatory cytokines including MCP-1, TNF-alpha, IL-6 and IL-1beta through inhibition of NF-kb/p65 phosphorylation, and that epithelial-mesenchymal transition (EMT) process was reversed by different compounds in different levels.	beta-carboline alkaloids	14-38	interleukin 1 beta	Mus musculus	166-174
31671623-5	2019	In addition, FMP treatment suppressed the production of proinflammatory cytokines such as prostaglandin-E2 (PGE2), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) in a dose-dependent manner and concomitantly decreased the mRNA expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2).	formononetin	13-16	interleukin 1 beta	Mus musculus	141-158
31671623-5	2019	In addition, FMP treatment suppressed the production of proinflammatory cytokines such as prostaglandin-E2 (PGE2), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) in a dose-dependent manner and concomitantly decreased the mRNA expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2).	formononetin	13-16	interleukin 1 beta	Mus musculus	160-168
31781635-14	2019	Besides, the ELISA results showed that TNF-alpha, IL-1beta, and IL-6 were reduced in LPS-stimulated RAW264.7 cells after interfering with quercetin and quercitrin.	Quercetin	138-147	interleukin 1 beta	Mus musculus	50-58
31781635-14	2019	Besides, the ELISA results showed that TNF-alpha, IL-1beta, and IL-6 were reduced in LPS-stimulated RAW264.7 cells after interfering with quercetin and quercitrin.	quercitrin	152-162	interleukin 1 beta	Mus musculus	50-58
31666643-9	2019	HFD induced interleukin (IL)-17, transforming growth factor (TGF)-beta1, and IL-1beta mRNA and protein expression, which was significantly reduced by empagliflozin, dulaglutide, and their combination.	empagliflozin	150-163	interleukin 1 beta	Mus musculus	77-85
31388826-4	2019	Exposure to 100% oxygen for 72 h in male C57BL/6 mice resulted in increased protein levels of tumor necrosis factor-alpha and interleukin-1beta in lung tissues, and aggravated lung histological alterations.	Oxygen	17-23	interleukin 1 beta	Mus musculus	126-143
31406023-4	2019	Moreover, inhibition of ER stress by 4-phenylbutyrate (4-PBA) attenuated thapsigargin-(TG, ER stress agonist) or LPS-induced reduction of Cyp19a1 and E2, pro-inflammatory cytokines expression (IL-1beta, IL-6, IL-8, and TNF-alpha), and the expression of CHOP and GRP78.	Thapsigargin	73-85	interleukin 1 beta	Mus musculus	193-201
31544965-3	2019	Here, we show that the thiol-specific peroxidase peroxiredoxin-4 (Prdx4) directly regulates IL-1beta generation by interfering with caspase-1 activity.	Sulfhydryl Compounds	23-28	interleukin 1 beta	Mus musculus	92-100
31631977-5	2019	This study aimed to determine whether aucubin could slow progression of OA in a mouse model and inhibit the IL-1beta-induced chondrocyte apoptosis.	aucubin	38-45	interleukin 1 beta	Mus musculus	108-116
31631977-14	2019	Furthermore, aucubin remarkably attenuated the IL-1beta-induced intracellular ROS production.	aucubin	13-20	interleukin 1 beta	Mus musculus	47-55
31054317-13	2019	Also, the combination therapy of (CUPE + Dox) leads to reducing the levels of serum IL-6, TNF-alpha, IL-1beta and tumor volume compared with untreated tumor-bearing mice and Dox groups.	Doxorubicin	41-44	interleukin 1 beta	Mus musculus	101-109
31636566-6	2019	Amurensin H also significantly inhibited the release of IL-1beta, IL-6, IL-8, and TNF-alpha in LPS-stimulated THP-1-derived macrophages.	amurensin H	0-11	interleukin 1 beta	Mus musculus	56-64
31406023-4	2019	Moreover, inhibition of ER stress by 4-phenylbutyrate (4-PBA) attenuated thapsigargin-(TG, ER stress agonist) or LPS-induced reduction of Cyp19a1 and E2, pro-inflammatory cytokines expression (IL-1beta, IL-6, IL-8, and TNF-alpha), and the expression of CHOP and GRP78.	4-phenylbutyric acid	37-53	interleukin 1 beta	Mus musculus	193-201
31406023-4	2019	Moreover, inhibition of ER stress by 4-phenylbutyrate (4-PBA) attenuated thapsigargin-(TG, ER stress agonist) or LPS-induced reduction of Cyp19a1 and E2, pro-inflammatory cytokines expression (IL-1beta, IL-6, IL-8, and TNF-alpha), and the expression of CHOP and GRP78.	4-phenylbutyric acid	55-60	interleukin 1 beta	Mus musculus	193-201
31600901-6	2019	Our data shows that the Dox treatment significantly increased expression of inflammasome markers (TLR4 and NLRP3), pyroptotic markers (caspase-1, IL1-beta, and IL-18), cell signaling proteins (MyD88, p-P38, and p-JNK), pro-inflammatory M1 macrophages, and TNF-alpha cytokine.	Doxorubicin	24-27	interleukin 1 beta	Mus musculus	146-154
31175486-4	2019	The results showed that ATP treatment induced lytic cell death morphologically resembling canonical pyroptosis in both MCC950-treated BMDMs and RAW264.7 cells, but did not cause the activation of caspase-1 (by detecting caspase-1p10 and mature interleukin-1beta) and cleavage of GSDMD.	Adenosine Triphosphate	24-27	interleukin 1 beta	Mus musculus	244-261
31395340-2	2019	Our results demonstrated that Verapamil reduced LPS-induced pathological damage of the lung tissue, infiltration of inflammatory cells and the production of IL-1beta, TNF-alpha, and MCP-1 in the serum.	Verapamil	30-39	interleukin 1 beta	Mus musculus	157-165
31271845-8	2019	DSS treated-P2ry6-/- mice exhibited also higher levels of Th17/Th1 lymphocytes in their colon which correlated with increased levels of IFN-gamma and IL-17A in the sera as well as increased mRNA levels of IFN-gamma, IL-17A, IL-6, IL-23 and IL-1beta in P2ry6-/- colons.	dss	0-3	interleukin 1 beta	Mus musculus	240-248
31545273-5	2019	BA reduced the serum levels of pro-inflammatory cytokines, such as IL-1alpha, IL-1beta, IL-5, IL-6, GM-CSF, KC, MCP-1 and PGE2 in Carr-treated mice, and increased those of anti-inflammatory cytokines, such as IL-12.	betulinic acid	0-2	interleukin 1 beta	Mus musculus	78-86
31325706-8	2019	QFG decreased the serum levels of TNF-alpha, IL-1beta, and IL-6 and increased the levels of IL-10.	qfg	0-3	interleukin 1 beta	Mus musculus	45-53
30632647-5	2019	Also, GEN-27 suppressed the release of LPS-induced pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and IL-18.	gen-27	6-12	interleukin 1 beta	Mus musculus	129-146
31250042-7	2019	Nox inhibitors, diphenyleneiodonium chloride and apocynin, significantly suppressed Hcy-induced IL-1beta and IL-6 expressions.	diphenyleneiodonium	16-44	interleukin 1 beta	Mus musculus	96-104
31250042-7	2019	Nox inhibitors, diphenyleneiodonium chloride and apocynin, significantly suppressed Hcy-induced IL-1beta and IL-6 expressions.	acetovanillone	49-57	interleukin 1 beta	Mus musculus	96-104
31250042-7	2019	Nox inhibitors, diphenyleneiodonium chloride and apocynin, significantly suppressed Hcy-induced IL-1beta and IL-6 expressions.	Homocysteine	84-87	interleukin 1 beta	Mus musculus	96-104
31250042-8	2019	In contrast, an IL-1beta receptor antagonist and an IL-6 receptor monoclonal antibody had no effects on Hcy-induced Nox1 and Nox2 expressions, but significantly rescued Hcy-induced apoptosis.	Homocysteine	169-172	interleukin 1 beta	Mus musculus	16-24
31250042-11	2019	Moreover, BZA significantly ameliorated Hcy-induced expressions of Nox1, Nox2, IL-1beta, and IL-6, and ICI canceled the effects of BZA on their expressions.	bazedoxifene	10-13	interleukin 1 beta	Mus musculus	79-87
31250042-11	2019	Moreover, BZA significantly ameliorated Hcy-induced expressions of Nox1, Nox2, IL-1beta, and IL-6, and ICI canceled the effects of BZA on their expressions.	Homocysteine	40-43	interleukin 1 beta	Mus musculus	79-87
31250042-12	2019	Hcy increases apoptosis through stimulating Nox 1 and Nox 2-IL-1beta and IL-6 expressions in osteocyte-like cells.	Homocysteine	0-3	interleukin 1 beta	Mus musculus	60-68
30632647-8	2019	Similarly, GEN-27 dose-dependently weakened adenosine triphosphate-induced NLRP3 and IL-1beta in RAW264.7 cells.	gen-27	11-17	interleukin 1 beta	Mus musculus	85-93
30632647-8	2019	Similarly, GEN-27 dose-dependently weakened adenosine triphosphate-induced NLRP3 and IL-1beta in RAW264.7 cells.	Adenosine Triphosphate	44-66	interleukin 1 beta	Mus musculus	85-93
30632647-5	2019	Also, GEN-27 suppressed the release of LPS-induced pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and IL-18.	gen-27	6-12	interleukin 1 beta	Mus musculus	148-156
31319131-6	2019	We found that the metformin pretreatment alleviated the lung injury and decreased the levels of TNF-a, IL-1beta and IL-6 in the bronchoalveolar lavage fluid (BALF) and in lung tissues, as well as the levels of NLRP3, NLRC4 and cleaved caspase-1 associated with LPS-induced ALI in old mice.	Metformin	18-27	interleukin 1 beta	Mus musculus	103-111
31530042-7	2019	Results: Pretreatment with RSV significantly and dose dependently inhibited LPS-induced production of TNF-alpha, IL-1beta and IL-6 in BV2 cells.	Resveratrol	27-30	interleukin 1 beta	Mus musculus	113-121
31452411-10	2019	Moreover, dioscin significantly inhibited TNF-alpha, IL-1beta, NF-kappaB, COX-2, and HMGB1 levels, and upregulated IL-10 levels.	dioscin	10-17	interleukin 1 beta	Mus musculus	53-61
30670576-9	2019	Elevated butyrate levels were associated with increased IL-1beta activity, while inhibition of the NOD-like receptor protein 3 by genetic, pharmacologic or dietary means markedly reduced colitis.	Butyrates	9-17	interleukin 1 beta	Mus musculus	56-64
31530042-10	2019	More importantly, the reducion of TNF-alpha, IL-1beta and IL-6 level by RSV were reversed by miR-146a-5p silence via miR-146a-5p inhibitor transfection.	Resveratrol	72-75	interleukin 1 beta	Mus musculus	45-53
31549524-6	2019	Results: The results show that kaempferol alleviates LPS-ATP mediated damage by increasing cell viability, improving membrane integrity, and decreasing the release of IL1b and IL-18.	Kaempferols	31-41	interleukin 1 beta	Mus musculus	167-171
31306981-5	2019	In addition, qPCR and ELISA results found that glycitin could dose-dependently decrease the expressions of pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	glycitin	47-55	interleukin 1 beta	Mus musculus	134-142
31352325-9	2019	Ac-Yvad-Cmk pretreatment effectively prevented the increase of Cleaved Caspase-1 and inhibited the maturity of IL-1beta.	ac-yvad	0-7	interleukin 1 beta	Mus musculus	111-119
31351366-7	2019	In vitro, farrerol markedly decreased the production of inflammatory mediators, including interleukin-6 (IL-6), interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), cyclooxygenase 2 (COX-2) and induced nitric oxide synthase (iNOS), induced by lipopolysaccharide (LPS) in BV-2 cells.	farrerol	10-18	interleukin 1 beta	Mus musculus	112-129
31330445-0	2019	Telmisartan, an angiotensin II receptor blocker, attenuates Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-1beta in murine macrophages.	Telmisartan	0-11	interleukin 1 beta	Mus musculus	140-157
31330445-3	2019	Telmisartan significantly inhibited LPS-induced generation of inducible nitric oxide (NO) synthase-derived NO and interleukin-1beta (IL-1beta) as well as their gene expressions in RAW264.7 cells.	Telmisartan	0-11	interleukin 1 beta	Mus musculus	114-131
31330445-3	2019	Telmisartan significantly inhibited LPS-induced generation of inducible nitric oxide (NO) synthase-derived NO and interleukin-1beta (IL-1beta) as well as their gene expressions in RAW264.7 cells.	Telmisartan	0-11	interleukin 1 beta	Mus musculus	133-141
31330445-7	2019	Telmisartan inhibited LPS-induced generation of NO and IL-1beta independently of PPAR-gamma activation.	Telmisartan	0-11	interleukin 1 beta	Mus musculus	55-63
31330445-9	2019	In summary, telmisartan is a potent inhibitor of P. intermedia LPS-induced generation of NO and IL-1beta in RAW264.7 cells and promotes macrophage phenotype switching toward the M2 phenotype.	Telmisartan	12-23	interleukin 1 beta	Mus musculus	96-104
31401380-6	2019	DHB was also observed to significantly decrease the production and mRNA expression levels of IL-6, IL-1beta, TNF-alpha, NO (iNOS) and PGE2 (COX-2), increase the release of IL-10, and inhibit the activation of NF-kappaB and MAPK signaling pathways.	dihydroberberine	0-3	interleukin 1 beta	Mus musculus	99-107
31364719-0	2019	Artesunate alleviates interleukin-1beta-induced inflammatory response and apoptosis by inhibiting the NF-kappaB signaling pathway in chondrocyte-like ATDC5 cells, and delays the progression of osteoarthritis in a mouse model.	Artesunate	0-10	interleukin 1 beta	Mus musculus	22-39
31432106-10	2019	In addition, ICA suppressed the production of pro-inflammatory cytokines, including interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha in the pancreas.	icariin	13-16	interleukin 1 beta	Mus musculus	84-106
31572984-12	2019	NQC dose-dependently down-regulated the pro-inflammatory cytokines [interleukin (IL)-1beta (13.27 +- 2.37 muM), IL-6 (10.13 +- 0.58 muM) and tumor necrosis factor (TNF)-alpha] (14.41 +- 1.83 muM); and inflammatory mediator, prostaglandin E2 (PGE2) with IC50 values, 15.23 +- 0.91 microM.	Nitrogen	0-3	interleukin 1 beta	Mus musculus	68-90
31378305-7	2019	RESULTS: Topical treatment with anisomycin induced key signatures in psoriasis, such as epidermal thickening, neutrophil infiltration, and gene expression of Il1a, Il1b, Il6, Il24, Cxcl1, Il23a, and Il17a, in treated murine skin.	Anisomycin	32-42	interleukin 1 beta	Mus musculus	164-168
31570110-10	2019	Confocal analysis of Iba1-stained retinal flatmounts and qPCR demonstrated that ONL1204 also abrogated microglia activation and inhibited the induction of multiple genes implicated in glaucoma, including cytokines and chemokines (GFAP, Caspase-8, TNFalpha, IL-1beta, IL-6, IL-18, MIP-1alpha, MIP-1beta, MIP-2, MCPI, and IP10), components of the complement cascade (C3, C1Q), Toll-like receptor pathway (TLR4), and inflammasome pathway (NLRP3).	hydroxylysyl-5-oxonorleucine	80-87	interleukin 1 beta	Mus musculus	257-265
31561220-11	2019	In Western blot, the expression of inflammasomes was higher after TBI in the sham group, but the expression of interleukin-1beta, caspase-1, and NLRP3 was decreased significantly following treatment with pioglitazone.	pioglitazone	204-216	interleukin 1 beta	Mus musculus	111-128
31302499-7	2019	Moreover, DMO induced morphological changes in the white adipose tissue, accompanied by reduced interleukin-1beta (IL-1beta) production and increased UCP1 expression.	desmethylolanzapine	10-13	interleukin 1 beta	Mus musculus	96-113
31454532-7	2019	As for macrophage M1/M2 polarization in liver, nano-celastrol reduced the expression of macrophage M1 biomarkers (e.g., IL-6, IL-1beta, TNF-alpha, iNOS) in a dose-dependent manner and marginally increased the expression of macrophage M2 biomarkers (e.g., Arg-1, IL-10).	celastrol	52-61	interleukin 1 beta	Mus musculus	126-134
31557885-7	2019	MGO treatment increased mRNA expression of inflammation-related molecules, interleukin (IL)-1beta, IL-6, and toll-like receptor 4 (TLR4).	Pyruvaldehyde	0-3	interleukin 1 beta	Mus musculus	75-97
31616405-6	2019	Following priming with LPS, both the canonical activator nigericin and cSiO2 elicited robust inflammasome activation in RAW-ASC cells, as reflected by IL-1beta release and caspase-1 activation.	Nigericin	57-66	interleukin 1 beta	Mus musculus	151-159
31616301-8	2019	Moreover, MH dramatically suppressed the inhibitor of kappa B alpha (IkappaBalpha) degradation and subsequent nuclear factor-kappa B (NF-kappaB) p65 translocation into the nucleus and NF-kappaB-mediated cytokines, such as tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6.	morin	10-12	interleukin 1 beta	Mus musculus	263-285
31546603-8	2019	Interestingly, the IL-1beta, IL-6, MCP-1, and ICAM-1 mRNA levels, which were increased in KK-Ay mouse kidneys as compared with normal controls, were suppressed by febuxostat administration.	febuxostat	163-173	interleukin 1 beta	Mus musculus	19-27
31616405-6	2019	Following priming with LPS, both the canonical activator nigericin and cSiO2 elicited robust inflammasome activation in RAW-ASC cells, as reflected by IL-1beta release and caspase-1 activation.	Silicon	71-76	interleukin 1 beta	Mus musculus	151-159
31616405-11	2019	DHA pre-incubation suppressed inflammasome activation and release of IL-1beta and IL-1alpha by nigericin, cSiO2, and two other crystals - monosodium urate and alum.	Docosahexaenoic Acids	0-3	interleukin 1 beta	Mus musculus	69-77
31616405-11	2019	DHA pre-incubation suppressed inflammasome activation and release of IL-1beta and IL-1alpha by nigericin, cSiO2, and two other crystals - monosodium urate and alum.	Nigericin	95-104	interleukin 1 beta	Mus musculus	69-77
31616405-11	2019	DHA pre-incubation suppressed inflammasome activation and release of IL-1beta and IL-1alpha by nigericin, cSiO2, and two other crystals - monosodium urate and alum.	Silicon	106-111	interleukin 1 beta	Mus musculus	69-77
31616405-11	2019	DHA pre-incubation suppressed inflammasome activation and release of IL-1beta and IL-1alpha by nigericin, cSiO2, and two other crystals - monosodium urate and alum.	Uric Acid	138-154	interleukin 1 beta	Mus musculus	69-77
31616405-12	2019	DHA"s suppressive effects were linked to inhibition of LPS-induced Nlrp3, Il1b, and Il1a transcription, potentially through the activation of PPARgamma.	Docosahexaenoic Acids	0-3	interleukin 1 beta	Mus musculus	74-78
31356776-7	2019	ACE2 activator resorcinolnaphthalein and inhibitor MLN-4760 significantly affected the histological appearance and wet/dry (W/D) ratio of the lung and altered the ACE2 activity of the lung, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) levels in bronchoalveolar lavage fluid (BALF) and myeloperoxidase (MPO) levels in lung tissue.	resorcinolnaphthalein	15-36	interleukin 1 beta	Mus musculus	234-251
31535222-11	2019	Regarding the stimulation for release of IL-1beta and TNF-alpha, Ti-35Nb and Ti-13Nb-13Zr alloys inhibited similarly the synthesis of these molecules.	ti-35nb	65-72	interleukin 1 beta	Mus musculus	41-49
31535222-11	2019	Regarding the stimulation for release of IL-1beta and TNF-alpha, Ti-35Nb and Ti-13Nb-13Zr alloys inhibited similarly the synthesis of these molecules.	ti-13nb-13zr	77-89	interleukin 1 beta	Mus musculus	41-49
31356776-7	2019	ACE2 activator resorcinolnaphthalein and inhibitor MLN-4760 significantly affected the histological appearance and wet/dry (W/D) ratio of the lung and altered the ACE2 activity of the lung, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) levels in bronchoalveolar lavage fluid (BALF) and myeloperoxidase (MPO) levels in lung tissue.	resorcinolnaphthalein	15-36	interleukin 1 beta	Mus musculus	253-261
31356776-7	2019	ACE2 activator resorcinolnaphthalein and inhibitor MLN-4760 significantly affected the histological appearance and wet/dry (W/D) ratio of the lung and altered the ACE2 activity of the lung, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) levels in bronchoalveolar lavage fluid (BALF) and myeloperoxidase (MPO) levels in lung tissue.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	51-59	interleukin 1 beta	Mus musculus	234-251
31632570-9	2019	The results revealed that NIM markedly improved pancreatic histological injury and decreased the levels of serum amylase, lipase, TNF-alpha, IL-1beta and IL-6 in a dose-dependent after NIM treatment.	nimesulide	26-29	interleukin 1 beta	Mus musculus	141-149
31356776-7	2019	ACE2 activator resorcinolnaphthalein and inhibitor MLN-4760 significantly affected the histological appearance and wet/dry (W/D) ratio of the lung and altered the ACE2 activity of the lung, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) levels in bronchoalveolar lavage fluid (BALF) and myeloperoxidase (MPO) levels in lung tissue.	2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid	51-59	interleukin 1 beta	Mus musculus	253-261
31632570-12	2019	The expression levels of TNF-alpha, IL-1beta and IL-6 proteins were downregulated following NIM treatment.	nimesulide	92-95	interleukin 1 beta	Mus musculus	36-44
31649847-10	2019	Additionally, Kin attenuated macrophage CM and IL-1beta-induced chondrocyte damage.	3-glucopyranosyloxybutanolide	14-17	interleukin 1 beta	Mus musculus	47-55
31340160-8	2019	In addition, 5 mg/kg andrographolide treatment also decreased the expression of pro-inflammatory mediators and cytokines (NO, COX-2, iNOS, IL-1beta, IL-6 and TNF-alpha), NF-kappaB signaling (p-p65, p-IkappaBalpha) and NLRP3 inflammasome assembly (NLRP3, ASC and caspase-1) in the prefrontal cortex.	andrographolide	21-36	interleukin 1 beta	Mus musculus	139-147
31572805-6	2019	The present study showed that DHM treatment alleviated LPS-induced viability reduction, suppressed the mRNA levels of IL-6, IL-1beta and TNF-alpha, inhibited the mRNA and protein expression of iNOS and COX-2, and attenuated the activation of NF-kB and TLR4 signaling in a concentration-dependent manner.	dihydromyricetin	30-33	interleukin 1 beta	Mus musculus	124-132
31572199-9	2019	Furthermore, dioscin obviously decreased the nuclear translocation of nuclear factor kappaB (NF-kappaB) and the mRNA levels of tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), and interleukin 6 (IL-6) to suppress inflammation.	dioscin	13-20	interleukin 1 beta	Mus musculus	168-185
31572199-9	2019	Furthermore, dioscin obviously decreased the nuclear translocation of nuclear factor kappaB (NF-kappaB) and the mRNA levels of tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), and interleukin 6 (IL-6) to suppress inflammation.	dioscin	13-20	interleukin 1 beta	Mus musculus	187-195
31572210-0	2019	Inhibition of IL-1beta by Aliskiren Improved Renal AQP2 Expression and Urinary Concentration Defect in Ureteral Obstruction and Release.	aliskiren	26-35	interleukin 1 beta	Mus musculus	14-22
31506384-7	2019	Furthermore, despite their inhibition of steady-state erythropoiesis in the bone marrow, the proinflammatory cytokines TNF-alpha and IL-1beta promoted the expansion and differentiation of SEPs in the spleen.	seps	188-192	interleukin 1 beta	Mus musculus	133-141
31278964-6	2019	Mechasnistic studies showed that GANT-61 and indomethacin synergistically attenuate the expressions of cell pyroptosis-related genes caspase-1, IL-1beta and IL-18 at mRNA and protein level.	Indomethacin	45-57	interleukin 1 beta	Mus musculus	144-152
31565031-12	2019	Sakuranetin did not modify in vitro cell viability in RAW 264.7 and reduced NO release and gene expression of IL-1beta and IL-6 induced by LPS in these cells.	sakuranetin	0-11	interleukin 1 beta	Mus musculus	110-118
31572210-6	2019	B-R3D increased the protein expression of NLRP3 inflammasome components ASC, caspase-1, and interleukin-1beta in the obstructed kidneys, which was markedly prevented by aliskiren.	aliskiren	169-178	interleukin 1 beta	Mus musculus	92-109
31511086-9	2019	The qRT-PCR analysis showed noticeable inhibition of pro-inflammatory cytokines (mRNA expression levels of TNF-alpha, IL-1beta and IL-6) (p &lt; 0.05) in poncirin treated group.	poncirin	154-162	interleukin 1 beta	Mus musculus	118-126
31201921-13	2019	The EGR1 inhibitor, ML264, protected chondrocytes from IL-1beta-mediated cartilage matrix degradation in vitro and DMM-induced osteoarthritis in vivo.	ML264	20-25	interleukin 1 beta	Mus musculus	55-63
31480531-8	2019	Furthermore, MEAC treatment prevents LPS-stimulated increases of proinflammatory cytokines, including TNF-alpha, IL-6, and IL-1beta.	meac	13-17	interleukin 1 beta	Mus musculus	123-131
30523572-5	2019	Through histopathologic examination staining, western blot, qPCR, and ELISA, the results showed that with increasing selenium concentrations, the expression levels of IL-1beta, TNF-alpha, NALP3, caspase-1, and ASC were decreased in mouse mammary tissue.	Selenium	117-125	interleukin 1 beta	Mus musculus	167-175
31299241-6	2019	The levels of pro-inflammatory cytokines were determined using ELISA and western blotting assays, showing that paraquat significantly promote the secretion of pro-inflammatory mediators such as tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta) and interleukin 6 (IL-6).	Paraquat	111-119	interleukin 1 beta	Mus musculus	235-252
31151536-5	2019	TSF2 polysaccharide effectively induced RAW264.7 murine macrophages to release nitric oxide, TNF-alpha, IL-1beta and IL-6, and activated NK cells to produce TNF-alpha, INF-gamma, granzyme-B, perforin, NKG2D and FasL through NF-kappaB and MAPKs signaling pathways.	Polysaccharides	5-19	interleukin 1 beta	Mus musculus	104-112
31299241-6	2019	The levels of pro-inflammatory cytokines were determined using ELISA and western blotting assays, showing that paraquat significantly promote the secretion of pro-inflammatory mediators such as tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta) and interleukin 6 (IL-6).	Paraquat	111-119	interleukin 1 beta	Mus musculus	254-262
31410125-6	2019	The gene expression of matrix metalloproteinase (MMP)1, MMP3, MMP13, interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha were reduced in the cartilage of OA mice following 7,8-DHF treatment.	6,7-dihydroxyflavone	181-188	interleukin 1 beta	Mus musculus	69-91
31277021-6	2019	Results revealed that nAl2O3 could increase ROS levels and decrease GSH levels in lung tissue, promote the increases of the T-IgE, TGF-beta, IL-1beta and IL-6 levels, stimulate the overexpression of transcription factors GATA-3 and RORgammat, decrease the levels of IFN-gamma and IL-10 and increase the levels of IL-4 and IL-17A, resulting in the imbalance of Th1/Th2 and Treg/Th17 immune responses.	nal2o3	22-28	interleukin 1 beta	Mus musculus	141-149
31313354-6	2019	The effects of SA exhibited in DSS-induced mice were associated with significant decrease in the expressions levels of inflammatory mediators such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), pro-inflammatory cytokines (tumor necrosis factor [TNF-alpha], interleukin [IL-1beta and IL-6]), remarkable amelioration of colonic architectural disruption, and a significant reduction in the activity of colonic myeloperoxidase.	syringic acid	15-17	interleukin 1 beta	Mus musculus	292-300
31313354-6	2019	The effects of SA exhibited in DSS-induced mice were associated with significant decrease in the expressions levels of inflammatory mediators such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), pro-inflammatory cytokines (tumor necrosis factor [TNF-alpha], interleukin [IL-1beta and IL-6]), remarkable amelioration of colonic architectural disruption, and a significant reduction in the activity of colonic myeloperoxidase.	Dextran Sulfate	31-34	interleukin 1 beta	Mus musculus	292-300
31313354-8	2019	SA dose-dependently inhibited the cytokines TNF-alpha, IL-1beta, and IL-6.	syringic acid	0-2	interleukin 1 beta	Mus musculus	55-63
31287602-7	2019	In addition, treatment with beta-carotene suppressed protein levels of TNF-alpha, IL-1beta and MCP-1, as well as mRNA expression associated with IL-1beta, IL-6, IL-4 and Par-2 in skin tissues.	beta Carotene	28-41	interleukin 1 beta	Mus musculus	82-90
31287602-7	2019	In addition, treatment with beta-carotene suppressed protein levels of TNF-alpha, IL-1beta and MCP-1, as well as mRNA expression associated with IL-1beta, IL-6, IL-4 and Par-2 in skin tissues.	beta Carotene	28-41	interleukin 1 beta	Mus musculus	145-153
31212009-8	2019	Urolithin A also attenuated IRI induced pro-inflammatory cytokines TNFalpha, IL1beta, MIP1alpha and MIP2 mRNA and associated kidney injury.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	0-11	interleukin 1 beta	Mus musculus	77-84
31452696-7	2019	After the mice were given TAK-242, the levels of hs-CPR, MCP-1, IL-6 and IL-1beta in the PT group evidently increased (P&lt;0.01) compared with those in the N group.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	26-33	interleukin 1 beta	Mus musculus	73-81
31410159-9	2019	TQ significantly inhibited the elevation of p62, IL-1beta, IL-6, MCP-1 and TNF-alpha levels as well as increased the LC3, beclin 1 and IL-10 levels in LT. PI3K expression in the TQ + CLP group was significantly decreased compared with that in the CLP group.	thymoquinone	0-2	interleukin 1 beta	Mus musculus	49-57
31463498-4	2019	Our data showed that SEO improved the cognitive ability of mice with Abeta1-42 or lipopolysaccharides (LPS)-induced Alzheimer"s disease (AD) and suppressed the production of tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) in the hippocampus.	seo	21-24	interleukin 1 beta	Mus musculus	233-250
30945296-9	2019	RESULTS: We found that metformin treatment can robustly ameliorate periodontal infection and tissue destruction and reduce blood glucose and serum IL-1beta levels in mice with diabetic periodontitis.	Metformin	23-32	interleukin 1 beta	Mus musculus	147-155
30878677-4	2019	cis-Khellactone clearly reduced the level of cytokines in psoriatic skin, including IL-23, TNF-alpha, IL-1beta, and IL-6, while limiting the inhibition of IL-17A, which is produced by T helper type 17 cells.	(+)-cis-Khellactone	0-15	interleukin 1 beta	Mus musculus	102-110
31195189-6	2019	Metformin prevented atrophy of myelinated axons, and reduced expression of inflammatory mediators (interleukin-1beta, inducible nitric oxide synthase and nitric oxide).	Metformin	0-9	interleukin 1 beta	Mus musculus	99-116
30740619-6	2019	In in vitro study, Arg-DG inhibited the production of nitric oxide (NO), nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) expression, and prostaglandin D2 production (PGD2), as well as the pro-inflammatory cytokines, such as interleukin (IL)-6, IL-1beta, and tumor necrosis factor alpha (TNF-alpha).	arg-dg	19-25	interleukin 1 beta	Mus musculus	251-259
31218683-10	2019	Moreover, SU-011 decreases the plasma levels of interleukin-1beta, tumour necrosis factor-alpha and C-reactive protein even better than that of dapagliflozin.	su-011	10-16	interleukin 1 beta	Mus musculus	48-95
31260687-9	2019	Besides, NMDA-induced ER stress strongly promoted pro-inflammatory cytokines synthesis (IL-1beta and TNF-alpha) in beta cells.	N-Methylaspartate	9-13	interleukin 1 beta	Mus musculus	88-96
31336157-10	2019	Coptisine significantly attenuated mature interleukin (IL)-1beta secretion in RAW264.7 macrophages stimulated with LPS plus ATP, nigericin, or MSU, by blocking caspase-1 activation.	coptisine	0-9	interleukin 1 beta	Mus musculus	42-64
31227976-14	2019	MiR-19b-3p mimic and GRK6 siRNA showed comparable inhibitory effect on IL-1beta-provoked NF-kappaB as reflected by the expression of p-p65.	mir-19b-3p	0-10	interleukin 1 beta	Mus musculus	71-79
31162334-15	2019	Induction of cleaved IL-1beta and NLRP2 in DRG neurons was similarly observed after ceramide injection.	Ceramides	84-92	interleukin 1 beta	Mus musculus	21-29
31336157-10	2019	Coptisine significantly attenuated mature interleukin (IL)-1beta secretion in RAW264.7 macrophages stimulated with LPS plus ATP, nigericin, or MSU, by blocking caspase-1 activation.	Adenosine Triphosphate	124-127	interleukin 1 beta	Mus musculus	42-64
31336157-10	2019	Coptisine significantly attenuated mature interleukin (IL)-1beta secretion in RAW264.7 macrophages stimulated with LPS plus ATP, nigericin, or MSU, by blocking caspase-1 activation.	Nigericin	129-138	interleukin 1 beta	Mus musculus	42-64
31336157-10	2019	Coptisine significantly attenuated mature interleukin (IL)-1beta secretion in RAW264.7 macrophages stimulated with LPS plus ATP, nigericin, or MSU, by blocking caspase-1 activation.	msu	143-146	interleukin 1 beta	Mus musculus	42-64
31336157-12	2019	Moreover, coptisine prevented LPS-mediated IL-1beta production and MSU-mediated mice paw edema by blocking NLRP3 inflammasome activation in vivo.	coptisine	10-19	interleukin 1 beta	Mus musculus	43-51
31555126-10	2019	Results: FX was found to decrease the expression of inflammatory cytokines including IL-6, IL-1beta, and TNF-alpha, in a prophylactic manner in the LPS-induced sepsis mouse model.	fucoxanthin	9-11	interleukin 1 beta	Mus musculus	91-99
31511209-3	2019	The release of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in RAW264.7 cells in response to pretreatment with 6, 8, and 10 mug/mL calenduloside E for 2 h followed by stimulation with 100 ng/mL LPS was detected using enzyme-linked immunosorbent assay (ELISA).	calenduloside E	190-205	interleukin 1 beta	Mus musculus	90-107
31511209-3	2019	The release of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in RAW264.7 cells in response to pretreatment with 6, 8, and 10 mug/mL calenduloside E for 2 h followed by stimulation with 100 ng/mL LPS was detected using enzyme-linked immunosorbent assay (ELISA).	calenduloside E	190-205	interleukin 1 beta	Mus musculus	109-117
31511209-7	2019	Calenduloside E dose-dependently decreased the expression levels of iNOS and COX-2 induced by LPS, inhibited LPS-induced release of TNF-alpha and IL-1beta, and suppressed LPS-induced JAK1-stat3 signaling pathway activation and stat3 nuclear translocation.	calenduloside	0-13	interleukin 1 beta	Mus musculus	146-154
31461951-4	2019	Our results revealed that subacute poisoning by 1,2-DCE upregulates protein levels of glial fibrillary acidic protein (GFAP), ionized calcium-binding adapter molecule 1 (Iba-1), interleukin-1beta (IL-1beta), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), inducible nitric oxide synthase (iNOS) and p-p65 in mouse brains.	ethylene dichloride	48-55	interleukin 1 beta	Mus musculus	178-195
31461951-4	2019	Our results revealed that subacute poisoning by 1,2-DCE upregulates protein levels of glial fibrillary acidic protein (GFAP), ionized calcium-binding adapter molecule 1 (Iba-1), interleukin-1beta (IL-1beta), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), inducible nitric oxide synthase (iNOS) and p-p65 in mouse brains.	ethylene dichloride	48-55	interleukin 1 beta	Mus musculus	197-205
31534976-16	2019	The depletion of MDMs by clodronate liposomes alleviated diabetes-induced tactile allodynia (P &lt; 0.05) and reduced the infiltration of MDMs (P &lt; 0.001) as well as the expression of IL-1beta and TNF-alpha in the spinal cord (P &lt; 0.05).	Clodronic Acid	25-35	interleukin 1 beta	Mus musculus	187-195
31132306-5	2019	Upon TPPU treatment, the liver steatosis and inflammatory damage were significantly ameliorated in mice with steatohepatitis, paralleled by the downregulation of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) as well as chemokines (CXCL1, MCP-1).	TPPU	5-9	interleukin 1 beta	Mus musculus	201-209
31455356-7	2019	RESULTS: Curcumin treatment markedly inhibited the degradation of IkappaBalpha, the activation of NF-kappaB signaling pathway, and the expression levels of the NF-kappaB downstream inflammatory genes such as IL-1beta, IL-6, TNF-alpha, COX-2, and PGE2 in the MSU-stimulated THP-1-derived macrophages.	Curcumin	9-17	interleukin 1 beta	Mus musculus	208-216
31461951-8	2019	Lastly, pretreatment with an antagonist against the IL-1beta receptor also attenuates changes in protein levels of p-p38 MAPK, p-p65, p-IkappaB, VCAM -1, ICAM-1, IL-1beta, and Iba-1 in the brain of 1,2-DCE-intoxicated-mice.	ethylene dichloride	198-205	interleukin 1 beta	Mus musculus	52-60
31429763-6	2019	RESULTS: We first observe that high-salt intake promotes atherosclerosis formation in the aortas of ApoE-/- mice, through inducing the expression of NFAT5, NLRP3, and IL-1beta in endothelium.	Salts	36-40	interleukin 1 beta	Mus musculus	167-175
31497013-6	2019	THC+CBD treatment also caused a decrease in the levels of brain infiltrating CD4+ T cells and pro-inflammatory molecules (IL-17, INF-gamma, TNF-alpha, IL-1beta, IL-6, and TBX21), while increasing anti-inflammatory phenotype such as FoxP3, STAT5b, IL-4, IL-10, and TGF-beta.	Dronabinol	0-3	interleukin 1 beta	Mus musculus	151-159
31497013-6	2019	THC+CBD treatment also caused a decrease in the levels of brain infiltrating CD4+ T cells and pro-inflammatory molecules (IL-17, INF-gamma, TNF-alpha, IL-1beta, IL-6, and TBX21), while increasing anti-inflammatory phenotype such as FoxP3, STAT5b, IL-4, IL-10, and TGF-beta.	Cannabidiol	4-7	interleukin 1 beta	Mus musculus	151-159
31429763-7	2019	Overexpression of NFAT5 activates NLRP3-inflammasome and increases the secretion of IL-1beta in ECs partly via ROS.	ros	111-114	interleukin 1 beta	Mus musculus	84-92
31429763-8	2019	Chromatin immunoprecipitation assay demonstrates that NFAT5 directly binds to the promoter regions of NLRP3 and IL-1beta in endothelial cells subjected to the high-salt environment.	Salts	164-168	interleukin 1 beta	Mus musculus	112-120
31292215-3	2019	In this study, we demonstrate that protein citrullination is common during pyroptotic cell death in macrophages and that inhibition of PAD enzyme activity by Cl-amidine, a pan-PAD inhibitor, blocks NLRP3 inflammasome assembly and proinflammatory IL-1beta release in macrophages.	N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide	158-168	interleukin 1 beta	Mus musculus	246-254
31495108-15	2019	After 48 hours, the expression of TNF-alpha, TGF-beta1, and IL-1beta in peripheral blood significantly increased by 39%, 45%, and 38%, respectively, in the PQ group (P&lt;0.05) , but they significantly decreased by 31%, 13%, and 22%, respectively, in the OPCs+PQ group as compared with the PQ group (P&lt;0.05) .	Paraquat	156-158	interleukin 1 beta	Mus musculus	60-68
31495108-15	2019	After 48 hours, the expression of TNF-alpha, TGF-beta1, and IL-1beta in peripheral blood significantly increased by 39%, 45%, and 38%, respectively, in the PQ group (P&lt;0.05) , but they significantly decreased by 31%, 13%, and 22%, respectively, in the OPCs+PQ group as compared with the PQ group (P&lt;0.05) .	Paraquat	260-262	interleukin 1 beta	Mus musculus	60-68
31495108-15	2019	After 48 hours, the expression of TNF-alpha, TGF-beta1, and IL-1beta in peripheral blood significantly increased by 39%, 45%, and 38%, respectively, in the PQ group (P&lt;0.05) , but they significantly decreased by 31%, 13%, and 22%, respectively, in the OPCs+PQ group as compared with the PQ group (P&lt;0.05) .	Paraquat	260-262	interleukin 1 beta	Mus musculus	60-68
31497232-8	2019	Escin also attenuated the hepatic myeloperoxidase (MPO) activity and hepatic pro-inflammatory cytokines (i.e., TNF-alpha, IL-1beta, IL-6 and IL-17).	Escin	0-5	interleukin 1 beta	Mus musculus	122-130
31497235-3	2019	We initially discovered that RSV significantly improved cardiac function and suppressed the expression of fibrosis markers, such as collagen-I, collagen-III, and fibronectin, and pro-inflammatory cytokines, including interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha).	Resveratrol	29-32	interleukin 1 beta	Mus musculus	217-234
31497235-3	2019	We initially discovered that RSV significantly improved cardiac function and suppressed the expression of fibrosis markers, such as collagen-I, collagen-III, and fibronectin, and pro-inflammatory cytokines, including interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha).	Resveratrol	29-32	interleukin 1 beta	Mus musculus	236-244
31178135-6	2019	Furthermore, CA-FA inhibited LPS-induced iNOS, COX-2, interleukin-6, and interleukin-1beta mRNA expressions in BV2 cells.	ca-fa	13-18	interleukin 1 beta	Mus musculus	73-90
31153827-0	2019	Lipidoid-siRNA Nanoparticle-Mediated IL-1beta Gene Silencing for Systemic Arthritis Therapy in a Mouse Model.	lipidoid	0-8	interleukin 1 beta	Mus musculus	37-45
31153827-2	2019	In the present study, we demonstrated that lipidoid-polymer hybrid nanoparticle (FS14-NP) can efficiently deliver siRNA against IL-1beta (siIL-1beta) to macrophages and effectively suppress the pathogenesis of experimental arthritis induced by collagen antibody (CAIA mice).	lipidoid	43-51	interleukin 1 beta	Mus musculus	128-136
31440160-13	2019	Furthermore, pretreatment with hydrogen resulted in cardioprotection during septic cardiomyopathy via inhibiting the expression of pro-inflammatory cytokines TNFalpha, IL-1beta, and IL-18; suppressing the phosphorylation of ERK1/2, p38, and JNK; and reducing the nuclear translocation of NF-kappaB and the expression of TLR4 by LPS.	Hydrogen	31-39	interleukin 1 beta	Mus musculus	168-176
31447572-9	2019	Inhibition of the NLRP3 inflammasome with MCC950 reduced the production of active caspase-1 and active IL-1beta in db/db mice and HG-induced mesangial cells.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	42-48	interleukin 1 beta	Mus musculus	103-111
31447572-13	2019	MCC950 effectively ameliorated diabetic kidney injury by inhibiting NLRP3/caspase-1/IL-1beta pathway, which may be a potential therapeutic strategy to prevent the progression of DN.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	0-6	interleukin 1 beta	Mus musculus	84-92
31215797-5	2019	Resveratrol also suppressed the overexpression of cleaved caspase-1 and IL-1beta, and decreased Abeta-stimulated degradation of IkBalpha and phosphorylation of NF-kappaB phosphorylation.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	72-80
30728466-12	2019	Furthermore, the olfactory bulbs in MPTP/P-treated mice showed significantly increased levels of interleukin-1beta (IL-1beta), caspase-1, glial fibrillary acidic protein (GFAP), Toll receptor 4 (TLR4), phosphorylation of p65, as well as activated molecules of NOD-like receptor protein 3 (NLRP3) that were associated with neuroinflammation.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	36-40	interleukin 1 beta	Mus musculus	97-114
30728466-12	2019	Furthermore, the olfactory bulbs in MPTP/P-treated mice showed significantly increased levels of interleukin-1beta (IL-1beta), caspase-1, glial fibrillary acidic protein (GFAP), Toll receptor 4 (TLR4), phosphorylation of p65, as well as activated molecules of NOD-like receptor protein 3 (NLRP3) that were associated with neuroinflammation.	Phosphorus	37-38	interleukin 1 beta	Mus musculus	97-114
31153100-0	2019	Structure-based design and synthesis of new 4-methylcoumarin-based lignans as pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-1beta) inhibitors.	4-Methylcoumarin	44-60	interleukin 1 beta	Mus musculus	126-134
31383251-5	2019	Furthermore, LA-Dec inhibited LPS-induced expressions of iNOS, COX-2, interleukin-6, tumor necrosis factor-alpha, and interleukin-1beta mRNA in BV2 cells, whereas the same concentration of LA or Dec was ineffective.	la-dec	13-19	interleukin 1 beta	Mus musculus	118-135
31383251-5	2019	Furthermore, LA-Dec inhibited LPS-induced expressions of iNOS, COX-2, interleukin-6, tumor necrosis factor-alpha, and interleukin-1beta mRNA in BV2 cells, whereas the same concentration of LA or Dec was ineffective.	decursin	16-19	interleukin 1 beta	Mus musculus	118-135
31121485-6	2019	Bilirubin prior to LPS treatment decreased protein expressions of Nlrp3, pro-interleukin (IL)-1beta and mature IL-1beta in PMs, whereas bilirubin post LPS treatment showed no effects.	Bilirubin	0-9	interleukin 1 beta	Mus musculus	111-119
31121485-7	2019	Bilirubin prior to LPS treatment dose-dependently repressed expressions of Nlrp3 and IL-1beta, and inhibited translocation of p-p65 to nucleus in Raw264.7 cells.	Bilirubin	0-9	interleukin 1 beta	Mus musculus	85-93
31121485-8	2019	Bilirubin treatment decreased myeloperoxidase activity and reduced the levels of inflammatory cytokines (i.e., IL-1beta, TNFalpha and IL-6) in lavage fluid in mice with alum-induced peritonitis.	Bilirubin	0-9	interleukin 1 beta	Mus musculus	111-119
31363726-11	2019	The results showed that CMP suppressed the expressions of CD68, IL-1beta, IL-6, and MCP-1 mRNA induced by STZ.	Streptozocin	106-109	interleukin 1 beta	Mus musculus	64-72
31229077-0	2019	Rape bee pollen alleviates dextran sulfate sodium (DSS)-induced colitis by neutralizing IL-1beta and regulating the gut microbiota in mice.	Dextran Sulfate	27-49	interleukin 1 beta	Mus musculus	88-96
31361289-6	2019	Furthermore, in a tetradecanoylphorbolacetate (TPA)-treated mouse model, AA and IA could effectively attenuate mouse ear edema and pathological damage and reduced levels of cytokines including iNOS, COX-2, TNF-alpha, and IL-1beta.	Tetradecanoylphorbol Acetate	47-50	interleukin 1 beta	Mus musculus	221-229
30937840-4	2019	The results showed that tizoxanide significantly suppressed production of NO as well as pro-inflammatory cytokines, such as IL-1beta, IL-6, and TNF-alpha in dose-dependent manner.	tizoxanide	24-34	interleukin 1 beta	Mus musculus	124-132
31151077-6	2019	cis-Cyclo(Val-Pro) (2) exhibited 57% inhibition of plasma IL-1beta protein expression and 35.2% inhibition of elevated blood urea nitrogen.	cis-cyclo	0-9	interleukin 1 beta	Mus musculus	58-66
31151077-6	2019	cis-Cyclo(Val-Pro) (2) exhibited 57% inhibition of plasma IL-1beta protein expression and 35.2% inhibition of elevated blood urea nitrogen.	L-valyl-L-proline	10-17	interleukin 1 beta	Mus musculus	58-66
31151077-7	2019	Further, cis-cyclo(Val-Pro) (2) attenuated renal injury as demonstrated by significant reduction of mRNA expressions of IL-1beta (P &lt; 0.01) and kidney injury marker-1 (P &lt; 0.001).	cis-cyclo	9-18	interleukin 1 beta	Mus musculus	120-128
31151077-7	2019	Further, cis-cyclo(Val-Pro) (2) attenuated renal injury as demonstrated by significant reduction of mRNA expressions of IL-1beta (P &lt; 0.01) and kidney injury marker-1 (P &lt; 0.001).	L-valyl-L-proline	19-26	interleukin 1 beta	Mus musculus	120-128
30847744-1	2019	Sinomenine (SIN) has been shown to protect against IL-1beta-induced chondrocyte apoptosis in vitro.	sinomenine	0-10	interleukin 1 beta	Mus musculus	51-59
30847744-1	2019	Sinomenine (SIN) has been shown to protect against IL-1beta-induced chondrocyte apoptosis in vitro.	sinomenine	12-15	interleukin 1 beta	Mus musculus	51-59
31129420-9	2019	Serum levels of TgAb, TNF-alpha, IL-6 and IL-1beta were also significantly higher in the NaI group but were dramatically reduced after rmGas6 injection.	Sodium Iodide	89-92	interleukin 1 beta	Mus musculus	42-50
31129420-9	2019	Serum levels of TgAb, TNF-alpha, IL-6 and IL-1beta were also significantly higher in the NaI group but were dramatically reduced after rmGas6 injection.	rmgas6	135-141	interleukin 1 beta	Mus musculus	42-50
31173183-6	2019	Total cell counts and the production of pro-inflammatory cytokines [tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6] in bronchoalveolar fluid were also decreased following treatment with sevoflurane.	Sevoflurane	200-211	interleukin 1 beta	Mus musculus	97-119
31080014-0	2019	Interleukin-1beta-induced IRAK1 ubiquitination is required for TH-GM-CSF cell differentiation in T cell-mediated inflammation.	Thorium	63-65	interleukin 1 beta	Mus musculus	0-17
31229077-0	2019	Rape bee pollen alleviates dextran sulfate sodium (DSS)-induced colitis by neutralizing IL-1beta and regulating the gut microbiota in mice.	Dextran Sulfate	51-54	interleukin 1 beta	Mus musculus	88-96
31255694-0	2019	Chaetocin attenuates gout in mice through inhibiting HIF-1alpha and NLRP3 inflammasome-dependent IL-1beta secretion in macrophages.	chaetocin	0-9	interleukin 1 beta	Mus musculus	97-105
30802544-4	2019	The functional S1PR1 antagonist FTY720 blocked NLRP3 activation and IL-1beta production.	Fingolimod Hydrochloride	32-38	interleukin 1 beta	Mus musculus	68-76
29451015-5	2019	Anti-inflammatory activity studies on 13 isolated compounds showed that beta-carboline constituents, especially compounds 1 and 2, significantly inhibited the expression of NO, TNF-alpha, IL-6 and IL-1beta in lipopolysaccharide (LPS)-treated RAW264.7 macrophage cells.	norharman	72-86	interleukin 1 beta	Mus musculus	197-205
31370192-6	2019	Interestingly, administering LB in MGO-treated cells and mice upregulated the expression of Nrf2 and Glo1, and downregulated the expression of IL-1beta and TNF-alpha.	Pyruvaldehyde	35-38	interleukin 1 beta	Mus musculus	143-151
30927265-6	2019	In addition, transforming growth factor beta, tumor necrosis factor alpha, interleukin 6 (IL-6), IL-23, IL-10, and IL-1beta levels were also greatly induced by high iron diet.	Iron	165-169	interleukin 1 beta	Mus musculus	115-123
31255694-4	2019	In the study, we found that chaetocin could decrease MSU induced IL-1beta secretion in bone marrow derived macrophages by several mechanisms, including inhibiting the activation of NLRP3 inflammasome.	chaetocin	28-37	interleukin 1 beta	Mus musculus	65-73
31255694-6	2019	Furthermore, chaetocin restrain expressions of Hypoxia-inducible factor-1alpha and Hexokinase 2, mediators of glycolysis, which necessary for synthesis of pro-IL-1beta during inflammasome priming.	chaetocin	13-22	interleukin 1 beta	Mus musculus	159-167
31379505-7	2019	GA-treated retinas showed significantly reduced expression of proinflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, CCL2 and 6, iNOS, and COX-2 (P &lt; 0.05), compared to that in non-treated retinas.	Glycyrrhizic Acid	0-2	interleukin 1 beta	Mus musculus	113-121
31319868-9	2019	The effect of CPFX and LVFX on LPS-induced release of IL-1beta and TNF-alpha and NF-kappaB activation was investigated in primary microglia by ELISA and fluorescence staining.	Ciprofloxacin	14-18	interleukin 1 beta	Mus musculus	54-62
31319868-9	2019	The effect of CPFX and LVFX on LPS-induced release of IL-1beta and TNF-alpha and NF-kappaB activation was investigated in primary microglia by ELISA and fluorescence staining.	Levofloxacin	23-27	interleukin 1 beta	Mus musculus	54-62
31814955-6	2019	Further mechanistic investigations demonstrated that TA combined with GA decreased the levels of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).	tolfenamic acid	53-55	interleukin 1 beta	Mus musculus	109-126
31814955-6	2019	Further mechanistic investigations demonstrated that TA combined with GA decreased the levels of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).	tolfenamic acid	53-55	interleukin 1 beta	Mus musculus	128-136
31814955-6	2019	Further mechanistic investigations demonstrated that TA combined with GA decreased the levels of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).	Glycyrrhizic Acid	70-72	interleukin 1 beta	Mus musculus	109-126
31814955-6	2019	Further mechanistic investigations demonstrated that TA combined with GA decreased the levels of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).	Glycyrrhizic Acid	70-72	interleukin 1 beta	Mus musculus	128-136
31814955-6	2019	Further mechanistic investigations demonstrated that TA combined with GA decreased the levels of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).	4-O-methyl-12-O-tetradecanoylphorbol 13-acetate	97-100	interleukin 1 beta	Mus musculus	109-126
31814955-6	2019	Further mechanistic investigations demonstrated that TA combined with GA decreased the levels of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).	4-O-methyl-12-O-tetradecanoylphorbol 13-acetate	97-100	interleukin 1 beta	Mus musculus	128-136
31187838-7	2019	In addition, the production of cytokines, such as IL-1beta, IL-18, IL-6, and TNF-alpha in mice livers, and acute-phase response (plasma levels of nitric oxide and C-reactive protein) were also decreased following GTP pre-treatment.	Guanosine Triphosphate	213-216	interleukin 1 beta	Mus musculus	50-58
31354429-10	2019	Notably, early clenbuterol treatment alleviated sepsis-induced cognitive deficits by polarizing microglia toward an anti-inflammatory phenotype, reducing proinflammatory cytokines including IL-1beta, TNF-alpha, and up-regulating CREB/BDNF, PSD95, and GluN2B.	Clenbuterol	15-26	interleukin 1 beta	Mus musculus	190-198
31354682-12	2019	The results showed that cecropin A and gentamicin relieved body weight loss, DAI, and gut mucosa disruption, while decreasing tumor necrosis factor-alpha (TNF-alpha), interlukin-1beta (IL-1beta), and interlukin-6 (IL-6) induced by DSS.	Gentamicins	39-49	interleukin 1 beta	Mus musculus	185-193
31288466-5	2019	Further tests showed that NJP significantly promoted phagocytic capacity, and the secretion of proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta).	NJP	26-29	interleukin 1 beta	Mus musculus	188-205
31288466-5	2019	Further tests showed that NJP significantly promoted phagocytic capacity, and the secretion of proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta).	NJP	26-29	interleukin 1 beta	Mus musculus	207-215
31269685-4	2019	Retinal endothelial cells (REC) treated with glycyrrhizin had reduced IL1beta and cleaved caspase 3 levels.	Glycyrrhizic Acid	45-57	interleukin 1 beta	Mus musculus	70-77
30951719-5	2019	Moreover, CT-133 significantly suppressed the primary neutrophil migration toward the PGD2 and robustly inhibited the mRNA and protein expression of IL-1beta, TNF-alpha, IL-6, and KC in primary and RAW264.7 macrophages in response to either LPS- or PGD2 stimulation.	ct-133	10-16	interleukin 1 beta	Mus musculus	149-157
30951719-5	2019	Moreover, CT-133 significantly suppressed the primary neutrophil migration toward the PGD2 and robustly inhibited the mRNA and protein expression of IL-1beta, TNF-alpha, IL-6, and KC in primary and RAW264.7 macrophages in response to either LPS- or PGD2 stimulation.	Prostaglandin D2	249-253	interleukin 1 beta	Mus musculus	149-157
31333451-7	2019	Renin was found to exacerbate the inflammation and periodontal bone loss at 14 days after PD, and Alisk inhibited this process in GT of N and D. PD increased CRP, CXCL2, CCL8, and IL-1beta production in both animals.	alisk	98-103	interleukin 1 beta	Mus musculus	180-188
31327964-7	2019	Melatonin increased mobility time of LPS-induced DLB mice and suppressed NLRP3 expression and interleukin-1beta (IL-1beta) cleavage in the hippocampus.	Melatonin	0-9	interleukin 1 beta	Mus musculus	94-111
30877025-8	2019	Following LPS treatment, PNU120596 hindered activation markers of the microglia and astrocytes (cluster of differentiation molecule 11b and glial fibrillary acidic protein) and upregulation of proinflammatory cytokines such as interleukin 1 beta and tumor necrosis factor-alpha in the hippocampus and prefrontal cortex.	1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea	25-34	interleukin 1 beta	Mus musculus	227-277
31327964-9	2019	Our results show that melatonin prevents LPS and Adenosine triphosphate (ATP) induced NLRP3 inflammasome activation in murine microglia in vitro, evidenced by inhibition of NLRP3 expression, Apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, caspase-1 cleavage and interleukin-1beta (IL-1beta) maturation and secretion.	Melatonin	22-31	interleukin 1 beta	Mus musculus	295-312
31384534-7	2019	Importantly, CDN improves the survival of mice suffering from lethal septic shock and attenuates IL-1beta production induced by LPS in vivo, which is shown to be NLRP3 dependent.	cardamonin	13-16	interleukin 1 beta	Mus musculus	97-105
31327964-9	2019	Our results show that melatonin prevents LPS and Adenosine triphosphate (ATP) induced NLRP3 inflammasome activation in murine microglia in vitro, evidenced by inhibition of NLRP3 expression, Apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, caspase-1 cleavage and interleukin-1beta (IL-1beta) maturation and secretion.	Adenosine	49-58	interleukin 1 beta	Mus musculus	295-312
31327964-9	2019	Our results show that melatonin prevents LPS and Adenosine triphosphate (ATP) induced NLRP3 inflammasome activation in murine microglia in vitro, evidenced by inhibition of NLRP3 expression, Apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, caspase-1 cleavage and interleukin-1beta (IL-1beta) maturation and secretion.	Adenosine Triphosphate	73-76	interleukin 1 beta	Mus musculus	295-312
31054505-10	2019	TPF could also decrease the expression levels of some pro-inflammatory factors, high dose TPF treated mice were with the reduction of (202.29 +- 18.58) pg/ml (tumor necrosis factor alpha, TNF-alpha), (53.69 +- 7.83) pg/ml (interleukin (IL)-1beta, IL-1beta), (48.44 +- 3.77) pg/ml (IL-6I, L-6) to the model separately.	TPF	0-3	interleukin 1 beta	Mus musculus	222-245
31091120-4	2019	URO-OVA mice developed responses consistent with pelvic and bladder pain after cystitis induction, which was associated with increased splenocyte production of TLR4-mediated proinflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	uro-ova	0-7	interleukin 1 beta	Mus musculus	200-208
31091120-7	2019	Intravenous administration of TAK-242 (a TLR4-selective antagonist) significantly attenuated nociceptive responses in cystitis-induced URO-OVA mice, which was associated with reduced splenocyte production of TLR4-mediated IL-1beta, IL-6, and TNF-alpha as well as reduced spinal expression of mRNAs for IL-6, TNF-alpha, CD11b, glial fibrillary acidic protein, and high mobility group box 1.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	30-37	interleukin 1 beta	Mus musculus	222-230
31054505-10	2019	TPF could also decrease the expression levels of some pro-inflammatory factors, high dose TPF treated mice were with the reduction of (202.29 +- 18.58) pg/ml (tumor necrosis factor alpha, TNF-alpha), (53.69 +- 7.83) pg/ml (interleukin (IL)-1beta, IL-1beta), (48.44 +- 3.77) pg/ml (IL-6I, L-6) to the model separately.	TPF	90-93	interleukin 1 beta	Mus musculus	222-245
31010959-6	2019	We found that LDL cholesterol lowering was dispensable, but statin-induced lowering of isoprenoids required for protein prenylation triggered NLRP3/caspase-1 inflammasome activation and interleukin-1beta (IL-1beta)-dependent insulin resistance in adipose tissue.	Terpenes	87-98	interleukin 1 beta	Mus musculus	186-203
31100367-0	2019	MiR-187-3p mimic alleviates ischemia-reperfusion-induced pain hypersensitivity through inhibiting spinal P2X7R and subsequent mature IL-1beta release in mice.	mir-187-3p	0-10	interleukin 1 beta	Mus musculus	133-141
31100367-14	2019	This finding was further supported by results showing that downregulating IL-1beta by A-438079 and IL-1beta-neutralizing antibody similarly decreased P2X7R, cleaved caspase-1 and mature IL-1beta expression levels, whereas BzATP treatment increased these levels.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	222-227	interleukin 1 beta	Mus musculus	74-82
31100367-17	2019	Increasing miR-187-3p protected against pain hypersensitivity and mature IL-1beta overproduction, partially through inhibiting P2X7R activation.	mir-187-3p	11-21	interleukin 1 beta	Mus musculus	73-81
31185753-6	2019	VX-765 inhibited ozone-induced BHR, BAL total cells including neutrophils and eosinophils, and BAL inflammatory cytokines including IL-1alpha, IL-1beta, KC, and IL-6.	belnacasan	0-6	interleukin 1 beta	Mus musculus	143-151
31004597-8	2019	In addition, 6-G suppressed BaP-induced colonic inflammation by decreasing MPO activity as well as nitrites, TNF-alpha, IL-1beta, COX-2 and iNOS levels when compared with BaP alone group.	gingerol	13-16	interleukin 1 beta	Mus musculus	120-128
30919410-0	2019	Brucella abortus nitric oxide metabolite regulates inflammasome activation and IL-1beta secretion in murine macrophages.	Nitric Oxide	17-29	interleukin 1 beta	Mus musculus	79-87
30919410-3	2019	Our group recently demonstrated that Brucella abortus-induced IL-1beta secretion involves NLRP3 inflammasome and it is partially dependent on mitochondrial ROS production.	ros	156-159	interleukin 1 beta	Mus musculus	62-70
30919410-8	2019	Additionally, our results suggest that B. abortus-induced IL-1beta secretion depends on a P2X7-independent potassium efflux, lysosomal acidification, cathepsin release, mechanisms clearly associated to NLRP3 inflammasome.	Potassium	107-116	interleukin 1 beta	Mus musculus	58-66
31010959-6	2019	We found that LDL cholesterol lowering was dispensable, but statin-induced lowering of isoprenoids required for protein prenylation triggered NLRP3/caspase-1 inflammasome activation and interleukin-1beta (IL-1beta)-dependent insulin resistance in adipose tissue.	Terpenes	87-98	interleukin 1 beta	Mus musculus	205-213
30959371-4	2019	Aloin treatment significantly ameliorated histopathological damage, attenuated the microglia activation and reduced levels of inflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 in the hippocampus.	alloin	0-5	interleukin 1 beta	Mus musculus	199-216
30959371-4	2019	Aloin treatment significantly ameliorated histopathological damage, attenuated the microglia activation and reduced levels of inflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 in the hippocampus.	alloin	0-5	interleukin 1 beta	Mus musculus	218-226
30978647-6	2019	Furthermore, it reduced DSS-induced production of reactive oxygen species (ROS), infiltration of macrophages, and expression of pro-inflammatory cytokines such as TNF-alpha, IL-6, and IL-1beta.	Dextran Sulfate	24-27	interleukin 1 beta	Mus musculus	184-192
31010959-11	2019	Our results show that statin lowering of prenylation isoprenoids activates caspase-1/IL-1beta inflammasome responses that impair endocrine control of adipocyte lipogenesis.	Terpenes	53-64	interleukin 1 beta	Mus musculus	85-93
31018046-9	2019	In contrast, the expression of IL-1beta and IL-18 increased after melatonin treatment.	Melatonin	66-75	interleukin 1 beta	Mus musculus	31-39
31059066-8	2019	TQ-5 improved LPS-induced liver injury in mice by inhibiting the expression of TNF-alpha, IL-1beta and iNOS and phosphorylation of NF-kappaBp65.	tq-5	0-4	interleukin 1 beta	Mus musculus	90-98
31059066-3	2019	The results demonstrated that TQ-5 suppressed the LPS-induced production of nitric oxide, tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS), without inducing cytotoxicity or damaging the morphology of the RAW 264.7 macrophages.	tq-5	30-34	interleukin 1 beta	Mus musculus	131-148
31059066-3	2019	The results demonstrated that TQ-5 suppressed the LPS-induced production of nitric oxide, tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS), without inducing cytotoxicity or damaging the morphology of the RAW 264.7 macrophages.	tq-5	30-34	interleukin 1 beta	Mus musculus	150-158
30891759-9	2019	Citral significantly reduced cytokines (IL-1beta, IL-6, TNF-alpha) and oxidative factors (malondialdehyde and hydroxyl radicals) of MRSA-infected mice, whereas it increased gluthtione and superoxide dismutase levels.	citral	0-6	interleukin 1 beta	Mus musculus	40-48
31082627-7	2019	The LPS-induced expression of interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor alpha could be downregulated by clomipramine pre-treatment both in vivo and in vitro.	Clomipramine	124-136	interleukin 1 beta	Mus musculus	30-47
31104354-4	2019	L-NAME challenge elicited hypertension, macrophage infiltration, oxidative stress, inflammation and cardiac dysfunction manifested as increased proinflammatory macrophage marker F4/80, interleukin-1beta (IL-1beta), intracellular O 2 -  production, LV end systolic and diastolic diameters as well as depressed fractional shortening.	NG-Nitroarginine Methyl Ester	0-6	interleukin 1 beta	Mus musculus	185-202
30748031-6	2019	IFN-gamma was vital for induction of the nitric oxide producing enzyme, iNOS, in infected joints, and nitric oxide directly inhibited IL-1beta production and inflammasome activation in Brucella-infected macrophages in vitro.	Nitric Oxide	102-114	interleukin 1 beta	Mus musculus	134-142
31358372-6	2019	Jaceosidin could down-regulate the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta), together with up-regulation the levels of interleukin-4 (IL-4) and interleukin-10 (IL-10) in BALF.	jaceosidin	0-10	interleukin 1 beta	Mus musculus	111-128
31358372-6	2019	Jaceosidin could down-regulate the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta), together with up-regulation the levels of interleukin-4 (IL-4) and interleukin-10 (IL-10) in BALF.	jaceosidin	0-10	interleukin 1 beta	Mus musculus	130-138
31068381-3	2019	In this study, JFNE was isolated by chromatography to obtain fraction D. We found that pretreatment of LPS-induced RAW264.7 cells with JFNE and fraction D for 3 hours significantly reduced the levels of nitric oxide (NO), interleukin (IL)-1beta, and tumor necrosis factor-alpha (TNF-alpha) in the supernatant of cell cultures, and fraction D could also reduce the level of IL-6.	jfne	15-19	interleukin 1 beta	Mus musculus	222-244
30942960-9	2019	In particular, MOR-treated GMSCs are able to reduce the spinal cord levels of COX-2, GFAP, and inflammatory cytokines IL-1beta and IL-6 and to restore spinal cord normal morphology.	moringin	15-18	interleukin 1 beta	Mus musculus	118-126
30942960-9	2019	In particular, MOR-treated GMSCs are able to reduce the spinal cord levels of COX-2, GFAP, and inflammatory cytokines IL-1beta and IL-6 and to restore spinal cord normal morphology.	gmscs	27-32	interleukin 1 beta	Mus musculus	118-126
31004726-14	2019	Besides, AP could significantly suppressed the 5-FU-mediated increases of the intestinal inflammatory cytokines (TNF-alpha, IFN-gamma, IL-6, IL-1beta and IL-17), while AMO or PGS only inhibited some of them after 5-FU chemotherapy.	Fluorouracil	47-51	interleukin 1 beta	Mus musculus	141-149
31321958-3	2019	Interleukin-1beta inhibited sodium currents in mouse hippocampal neurons and verified that protein kinase C epsilon contributed to the effect of Interleukin-1beta exposure.	Sodium	28-34	interleukin 1 beta	Mus musculus	0-17
31263138-5	2019	Here we show that treatment with PPARgamma agonists (rosiglitazone or pioglitazone) in primary cultures of mouse glial cells reversed EcoHIV-induced inflammatory genes (TNFalpha, IL-1beta, CCL2, CCL3, CXCL10) and indicator of oxidative stress (iNOS).	Rosiglitazone	53-66	interleukin 1 beta	Mus musculus	179-187
31263138-5	2019	Here we show that treatment with PPARgamma agonists (rosiglitazone or pioglitazone) in primary cultures of mouse glial cells reversed EcoHIV-induced inflammatory genes (TNFalpha, IL-1beta, CCL2, CCL3, CXCL10) and indicator of oxidative stress (iNOS).	Pioglitazone	70-82	interleukin 1 beta	Mus musculus	179-187
31293389-11	2019	CsA attenuated IL-1beta and Iba1 expressions in BV-2 microglia exposed to OGD/R.	Cyclosporine	0-3	interleukin 1 beta	Mus musculus	15-23
31316501-5	2019	Hepatocytes were found to be insensitive to TLR2- and TLR4-stimulants directly, but their secretion of functional cholesterol acceptors was impaired by interleukin (IL)-1beta released by TLR-responsive hepatic macrophages.	Cholesterol	114-125	interleukin 1 beta	Mus musculus	152-174
31234344-4	2019	We found that DHA enclosed in RV-SLNs significantly enhanced its ability to contrast the cytotoxic effect of SDS and to inhibit the SDS- and TNF-alpha-induced production of the inflammatory cytokines IL-1beta, IL-6, and 1 MCP-1, in the two keratinocyte cell lines, as well as the NLRP3 inflammasome activation.	Docosahexaenoic Acids	14-17	interleukin 1 beta	Mus musculus	200-208
31234344-4	2019	We found that DHA enclosed in RV-SLNs significantly enhanced its ability to contrast the cytotoxic effect of SDS and to inhibit the SDS- and TNF-alpha-induced production of the inflammatory cytokines IL-1beta, IL-6, and 1 MCP-1, in the two keratinocyte cell lines, as well as the NLRP3 inflammasome activation.	Sodium Dodecyl Sulfate	132-135	interleukin 1 beta	Mus musculus	200-208
31317039-7	2019	Furthermore, alpha-ketoglutarate also exhibited immunomodulatory effects mediated via downregulation of interleukin (IL)-6, IL-22, tumour necrosis factor (TNF)-alpha, and IL-1beta cytokines.	Ketoglutaric Acids	13-32	interleukin 1 beta	Mus musculus	171-179
31207963-9	2019	Moreover, fisetin treatment inhibited LPS-induced activation of the inflammatory Toll-like Receptors (TLR4)/cluster of differentiation 14 (CD14)/phospho-nuclear factor kappa (NF-kappaB) signaling and attenuated other inflammatory mediators (tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL1-beta), and cyclooxygenase (COX-2).	fisetin	10-17	interleukin 1 beta	Mus musculus	282-300
31207963-9	2019	Moreover, fisetin treatment inhibited LPS-induced activation of the inflammatory Toll-like Receptors (TLR4)/cluster of differentiation 14 (CD14)/phospho-nuclear factor kappa (NF-kappaB) signaling and attenuated other inflammatory mediators (tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL1-beta), and cyclooxygenase (COX-2).	fisetin	10-17	interleukin 1 beta	Mus musculus	302-310
31066272-7	2019	Importantly, exposure of the macrophages to chlorinated nucleosides, particularly 8ClG and 5ClC, resulted in the increased expression of interleukin-1beta, and other pro-inflammatory cytokines and chemokines.	chlorinated nucleosides	44-67	interleukin 1 beta	Mus musculus	137-154
31066272-7	2019	Importantly, exposure of the macrophages to chlorinated nucleosides, particularly 8ClG and 5ClC, resulted in the increased expression of interleukin-1beta, and other pro-inflammatory cytokines and chemokines.	8-chloroguanosine	82-86	interleukin 1 beta	Mus musculus	137-154
31066272-7	2019	Importantly, exposure of the macrophages to chlorinated nucleosides, particularly 8ClG and 5ClC, resulted in the increased expression of interleukin-1beta, and other pro-inflammatory cytokines and chemokines.	5clc	91-95	interleukin 1 beta	Mus musculus	137-154
30904524-8	2019	Results showed ASPP could inhibit the levels of nitric oxide, interleukin (IL)-6, IL-1beta and TNF-alpha but increase the production of IL-10 in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells.	aspp	15-19	interleukin 1 beta	Mus musculus	82-90
30904524-9	2019	In addition ASPP could reduce the secretion of IL-6, IL-1beta and TNF-alpha in LPS-treated mice.	aspp	12-16	interleukin 1 beta	Mus musculus	53-61
31308853-7	2019	Autophagosomes secreted by FFCT-treated CT26.WT cells can activate M1 type macrophages, accompanied with increased expression of costimulatory molecules CD86 and CD40 on the surface of RAW264.7 cells, and more inflammatory cytokines secretion, such as TNF-alpha, IL-6, MCP-1, and IL-1beta.	ffct	27-31	interleukin 1 beta	Mus musculus	280-288
31244833-5	2019	Serum concentrations of TNF-alpha, IFN-gamma, and IL-1beta, as well as cardiac gene expression of pro-inflammatory mediators, were reduced after BA5 treatment.	ba5	145-148	interleukin 1 beta	Mus musculus	50-58
31182681-7	2019	Inhibition of NLRP3 or NF-kappaB by Bay11-7082 caused a reduction in the KA-induced expression of interleukin (IL)-1beta and BDNF.	3-(4-methylphenylsulfonyl)-2-propenenitrile	36-46	interleukin 1 beta	Mus musculus	98-120
31338007-7	2019	Thus, components of the inflammasome, such as ASC and NLRP3, significantly increased by DON treatment; in addition, the knockdown of ASC and NLRP3 markedly downregulated DON-induced IL-1beta secretion, but not IL-1beta gene expression, which indicated that DON promoted IL-1beta secretion through the ASC/NLRP3 inflammasome.	deoxynivalenol	170-173	interleukin 1 beta	Mus musculus	182-190
31338007-7	2019	Thus, components of the inflammasome, such as ASC and NLRP3, significantly increased by DON treatment; in addition, the knockdown of ASC and NLRP3 markedly downregulated DON-induced IL-1beta secretion, but not IL-1beta gene expression, which indicated that DON promoted IL-1beta secretion through the ASC/NLRP3 inflammasome.	deoxynivalenol	170-173	interleukin 1 beta	Mus musculus	210-218
31338007-7	2019	Thus, components of the inflammasome, such as ASC and NLRP3, significantly increased by DON treatment; in addition, the knockdown of ASC and NLRP3 markedly downregulated DON-induced IL-1beta secretion, but not IL-1beta gene expression, which indicated that DON promoted IL-1beta secretion through the ASC/NLRP3 inflammasome.	deoxynivalenol	170-173	interleukin 1 beta	Mus musculus	210-218
31338007-7	2019	Thus, components of the inflammasome, such as ASC and NLRP3, significantly increased by DON treatment; in addition, the knockdown of ASC and NLRP3 markedly downregulated DON-induced IL-1beta secretion, but not IL-1beta gene expression, which indicated that DON promoted IL-1beta secretion through the ASC/NLRP3 inflammasome.	deoxynivalenol	170-173	interleukin 1 beta	Mus musculus	182-190
31338007-7	2019	Thus, components of the inflammasome, such as ASC and NLRP3, significantly increased by DON treatment; in addition, the knockdown of ASC and NLRP3 markedly downregulated DON-induced IL-1beta secretion, but not IL-1beta gene expression, which indicated that DON promoted IL-1beta secretion through the ASC/NLRP3 inflammasome.	deoxynivalenol	170-173	interleukin 1 beta	Mus musculus	210-218
31338007-7	2019	Thus, components of the inflammasome, such as ASC and NLRP3, significantly increased by DON treatment; in addition, the knockdown of ASC and NLRP3 markedly downregulated DON-induced IL-1beta secretion, but not IL-1beta gene expression, which indicated that DON promoted IL-1beta secretion through the ASC/NLRP3 inflammasome.	deoxynivalenol	170-173	interleukin 1 beta	Mus musculus	210-218
31338007-8	2019	Collectively, the data suggested that DON induced IL-1beta expression in BV2 microglial cells through the activation of the NF-kappaB signaling pathway and the subsequent upregulation of the ASC/NLRP3 inflammasome.	deoxynivalenol	38-41	interleukin 1 beta	Mus musculus	50-58
31338007-9	2019	Therefore, DON may induce inflammatory diseases or disorders by activating IL-1beta expression.	deoxynivalenol	11-14	interleukin 1 beta	Mus musculus	75-83
31338007-2	2019	However, it is unknown whether DON stimulates IL-1beta expression through the activation of the nuclear factor-kappaB (NF-kappaB) pathway and the ACS/NLRP3 inflammasome.	deoxynivalenol	31-34	interleukin 1 beta	Mus musculus	46-54
31338007-4	2019	DON also upregulated IL-1beta expression from between 0.5 h and 6 h after treatment, and enhanced the nuclear localization of the NF-kappaB subunits, p50 and p65.	deoxynivalenol	0-3	interleukin 1 beta	Mus musculus	21-29
31338007-5	2019	NF-kappaB inhibitors, pyrrolidinedithiocarbamate and PS1145, significantly suppressed the DON-induced IL-1beta expression, which indicated that DON increased IL-1beta expression through the activation of NF-kappaB.	pyrrolidine dithiocarbamic acid	22-48	interleukin 1 beta	Mus musculus	102-110
31338007-5	2019	NF-kappaB inhibitors, pyrrolidinedithiocarbamate and PS1145, significantly suppressed the DON-induced IL-1beta expression, which indicated that DON increased IL-1beta expression through the activation of NF-kappaB.	pyrrolidine dithiocarbamic acid	22-48	interleukin 1 beta	Mus musculus	158-166
31338007-5	2019	NF-kappaB inhibitors, pyrrolidinedithiocarbamate and PS1145, significantly suppressed the DON-induced IL-1beta expression, which indicated that DON increased IL-1beta expression through the activation of NF-kappaB.	PS1145	53-59	interleukin 1 beta	Mus musculus	102-110
31338007-5	2019	NF-kappaB inhibitors, pyrrolidinedithiocarbamate and PS1145, significantly suppressed the DON-induced IL-1beta expression, which indicated that DON increased IL-1beta expression through the activation of NF-kappaB.	PS1145	53-59	interleukin 1 beta	Mus musculus	158-166
31338007-5	2019	NF-kappaB inhibitors, pyrrolidinedithiocarbamate and PS1145, significantly suppressed the DON-induced IL-1beta expression, which indicated that DON increased IL-1beta expression through the activation of NF-kappaB.	deoxynivalenol	90-93	interleukin 1 beta	Mus musculus	102-110
31338007-5	2019	NF-kappaB inhibitors, pyrrolidinedithiocarbamate and PS1145, significantly suppressed the DON-induced IL-1beta expression, which indicated that DON increased IL-1beta expression through the activation of NF-kappaB.	deoxynivalenol	90-93	interleukin 1 beta	Mus musculus	158-166
31338007-5	2019	NF-kappaB inhibitors, pyrrolidinedithiocarbamate and PS1145, significantly suppressed the DON-induced IL-1beta expression, which indicated that DON increased IL-1beta expression through the activation of NF-kappaB.	deoxynivalenol	144-147	interleukin 1 beta	Mus musculus	102-110
31338007-5	2019	NF-kappaB inhibitors, pyrrolidinedithiocarbamate and PS1145, significantly suppressed the DON-induced IL-1beta expression, which indicated that DON increased IL-1beta expression through the activation of NF-kappaB.	deoxynivalenol	144-147	interleukin 1 beta	Mus musculus	158-166
31338007-6	2019	In addition, marked secretion of IL-1beta protein occurred in the presence of DON at 24 h, and a caspase-1 inhibitor suppressed DON-mediated IL-1beta secretion, which suggested that caspase-1 induced the cleavage of pro-IL-1beta to lead the secretion of its active form.	deoxynivalenol	78-81	interleukin 1 beta	Mus musculus	33-41
31338007-6	2019	In addition, marked secretion of IL-1beta protein occurred in the presence of DON at 24 h, and a caspase-1 inhibitor suppressed DON-mediated IL-1beta secretion, which suggested that caspase-1 induced the cleavage of pro-IL-1beta to lead the secretion of its active form.	deoxynivalenol	128-131	interleukin 1 beta	Mus musculus	33-41
31338007-6	2019	In addition, marked secretion of IL-1beta protein occurred in the presence of DON at 24 h, and a caspase-1 inhibitor suppressed DON-mediated IL-1beta secretion, which suggested that caspase-1 induced the cleavage of pro-IL-1beta to lead the secretion of its active form.	deoxynivalenol	128-131	interleukin 1 beta	Mus musculus	141-149
31338007-6	2019	In addition, marked secretion of IL-1beta protein occurred in the presence of DON at 24 h, and a caspase-1 inhibitor suppressed DON-mediated IL-1beta secretion, which suggested that caspase-1 induced the cleavage of pro-IL-1beta to lead the secretion of its active form.	deoxynivalenol	128-131	interleukin 1 beta	Mus musculus	141-149
31338007-7	2019	Thus, components of the inflammasome, such as ASC and NLRP3, significantly increased by DON treatment; in addition, the knockdown of ASC and NLRP3 markedly downregulated DON-induced IL-1beta secretion, but not IL-1beta gene expression, which indicated that DON promoted IL-1beta secretion through the ASC/NLRP3 inflammasome.	deoxynivalenol	88-91	interleukin 1 beta	Mus musculus	182-190
31338007-7	2019	Thus, components of the inflammasome, such as ASC and NLRP3, significantly increased by DON treatment; in addition, the knockdown of ASC and NLRP3 markedly downregulated DON-induced IL-1beta secretion, but not IL-1beta gene expression, which indicated that DON promoted IL-1beta secretion through the ASC/NLRP3 inflammasome.	deoxynivalenol	88-91	interleukin 1 beta	Mus musculus	210-218
31338007-7	2019	Thus, components of the inflammasome, such as ASC and NLRP3, significantly increased by DON treatment; in addition, the knockdown of ASC and NLRP3 markedly downregulated DON-induced IL-1beta secretion, but not IL-1beta gene expression, which indicated that DON promoted IL-1beta secretion through the ASC/NLRP3 inflammasome.	deoxynivalenol	88-91	interleukin 1 beta	Mus musculus	210-218
31182681-9	2019	Notably, IL-1beta was shown to exert positive effects on the expression of BACE1, which is blocked by Bay11-7082.	3-(4-methylphenylsulfonyl)-2-propenenitrile	102-112	interleukin 1 beta	Mus musculus	9-17
31174271-4	2019	EGCG blocked MSU crystal-induced production of caspase-1(p10) and interleukin-1beta in primary mouse macrophages, indicating its suppressive effect on the NLRP3 inflammasome.	epigallocatechin gallate	0-4	interleukin 1 beta	Mus musculus	66-83
31170999-8	2019	RESULTS: NMDA-induced damage included neuronal cell death, microglial reactivity, upregulation of pro-inflammatory cytokines, and genes associated with IL1beta-signaling in different types of retinal neurons and glia.	N-Methylaspartate	9-13	interleukin 1 beta	Mus musculus	152-159
30925455-10	2019	Honokiol significantly decreases the expression of TNF-alpha, IL-1beta and IL-6 and decreases expression level of TRPV1 and P2Y.	honokiol	0-8	interleukin 1 beta	Mus musculus	62-70
30874838-10	2019	TFDG significantly suppressed the expression of IL-1beta, TNF-alpha, and IL-6, as well as the levels of MMP-1, MMP-2, and MMP-3 in the synovium.	theaflavin-3,3'-digallate	0-4	interleukin 1 beta	Mus musculus	48-56
31174699-4	2019	Here, results showed that pretreatment with rapamycin reduced the pyroptosis of peritoneal macrophages stimulated by cecal contents and the release of inflammatory factors such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha); In septic mice, rapamycin treatment decreased the activation of inflammasome in lung, and alleviated the pathological injuries in lung, liver and spleen tissues during acute stage of sepsis.	Sirolimus	44-53	interleukin 1 beta	Mus musculus	180-197
31262458-10	2019	In vivo experiments revealed that the number of inflammatory cells and IL-1beta in BALF of mice decrease after CKF treatment.	ckf	111-114	interleukin 1 beta	Mus musculus	71-79
31174699-4	2019	Here, results showed that pretreatment with rapamycin reduced the pyroptosis of peritoneal macrophages stimulated by cecal contents and the release of inflammatory factors such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha); In septic mice, rapamycin treatment decreased the activation of inflammasome in lung, and alleviated the pathological injuries in lung, liver and spleen tissues during acute stage of sepsis.	Sirolimus	44-53	interleukin 1 beta	Mus musculus	199-207
30991142-4	2019	Intraperitoneal injection of acetaminophen (APAP) elicited a progressive course of ALI in mice, which was developed from 12 to 24 h post injection along with liver inflammation evident by macrophage infiltration and upregulations of cytokines (IL-1beta, IL-6 and TNF-alpha); these alterations were concurrently occurred with a robust and progressive production of serum Prdx1.	Acetaminophen	29-42	interleukin 1 beta	Mus musculus	244-252
30991142-4	2019	Intraperitoneal injection of acetaminophen (APAP) elicited a progressive course of ALI in mice, which was developed from 12 to 24 h post injection along with liver inflammation evident by macrophage infiltration and upregulations of cytokines (IL-1beta, IL-6 and TNF-alpha); these alterations were concurrently occurred with a robust and progressive production of serum Prdx1.	Acetaminophen	44-48	interleukin 1 beta	Mus musculus	244-252
30933843-6	2019	On the other hand, ambroxol treatment significantly reduced imiquimod-induced levels of inflammatory cytokines such as IL-1beta, IL-6, IL-17, IL-22, IL-23, TGF-beta, and TNF-alpha.	Ambroxol	19-27	interleukin 1 beta	Mus musculus	119-127
31026586-5	2019	The cytokines TNF-alpha, IL-1beta, and IL-6 in colon samples were also significantly downregulated by H2S.	Hydrogen Sulfide	102-105	interleukin 1 beta	Mus musculus	25-33
31026586-8	2019	Our experimental results also suggested that H2S dose-dependently inhibits the activation of NLRP3 inflammasome in bone marrow-derived macrophages (BMDMs) by reducing the cleavage of caspase-1 and the secretion of IL-1beta.	Hydrogen Sulfide	45-48	interleukin 1 beta	Mus musculus	214-222
31018175-9	2019	Aortic F4/80, Il-1b and Il-6 expression were significantly inhibited both by testosterone administration.	Testosterone	77-89	interleukin 1 beta	Mus musculus	14-19
31018175-10	2019	Indeed, mice with implanted flutamide exhibited exacerbated AAA formation and aortic F4/80, Il-1b and Il-6 expression were significantly increased.	Flutamide	28-37	interleukin 1 beta	Mus musculus	92-97
30578820-9	2019	These results show that UVB induces IL-1beta secretion through cross-talk between Ca2+ and reactive oxygen species, providing insight towards potential targets against UVB-induced inflammation.	Reactive Oxygen Species	91-114	interleukin 1 beta	Mus musculus	36-44
30954529-4	2019	Our results showed that both amphotericin B and its liposomal form at various doses induced obvious depression-like behaviors in naive mice, likely owing to increased serum interleukin-6 (IL-6) and IL-1beta levels.	Amphotericin B	29-43	interleukin 1 beta	Mus musculus	198-206
30978648-10	2019	Icariin treatment prominently mitigated the protein expression of proinflammatory factors like nuclear factor-kappaB, cyclooxygenase-2, interleukin 1-beta and prooxidative enzyme (NADPH oxidase-4), and it increased the protein expression of antioxidative enzymes (superoxide dismutase and catalase).	icariin	0-7	interleukin 1 beta	Mus musculus	136-154
31009850-13	2019	Additionally, bavachin suppressed NLRP3 inflammasome-derived IL-1beta secretion, decreased caspase-1 activation, repressed mature IL-1beta expression, and inhibited inflammasome complex formation.	bavachin	14-22	interleukin 1 beta	Mus musculus	61-69
31009850-13	2019	Additionally, bavachin suppressed NLRP3 inflammasome-derived IL-1beta secretion, decreased caspase-1 activation, repressed mature IL-1beta expression, and inhibited inflammasome complex formation.	bavachin	14-22	interleukin 1 beta	Mus musculus	130-138
31155798-8	2019	Furthermore, treatment with kaempferitrin decreased paw thickness and arthritis scores, and reduced the serum levels of IL-1beta, IL-6, and TNF-alpha in a collagen-induced arthritis mouse model.	lespenefril	28-41	interleukin 1 beta	Mus musculus	120-128
30612190-6	2019	In support of the essential cytokine contribution in the AR-agonist induced SAA production is the fact that the anti-inflammatory drug, sodium salicylate, prevented the AR-stimulated hepatic SAA1/2 synthesis by reducing IL-1beta levels, whereas IL-1beta inhibition with Anakinra mimics this sodium salicylate preventive effect, thus indicating a crucial role for IL-1beta.	Sodium Salicylate	136-153	interleukin 1 beta	Mus musculus	220-228
30612190-6	2019	In support of the essential cytokine contribution in the AR-agonist induced SAA production is the fact that the anti-inflammatory drug, sodium salicylate, prevented the AR-stimulated hepatic SAA1/2 synthesis by reducing IL-1beta levels, whereas IL-1beta inhibition with Anakinra mimics this sodium salicylate preventive effect, thus indicating a crucial role for IL-1beta.	Sodium Salicylate	136-153	interleukin 1 beta	Mus musculus	245-253
30612190-6	2019	In support of the essential cytokine contribution in the AR-agonist induced SAA production is the fact that the anti-inflammatory drug, sodium salicylate, prevented the AR-stimulated hepatic SAA1/2 synthesis by reducing IL-1beta levels, whereas IL-1beta inhibition with Anakinra mimics this sodium salicylate preventive effect, thus indicating a crucial role for IL-1beta.	Sodium Salicylate	136-153	interleukin 1 beta	Mus musculus	245-253
31089880-3	2019	To explain this extracellular ATP is a potent activator of the Nrlp3 inflammasome, which leads to the release of interleukin 1beta and interleukin 18, as well as several danger-associated molecular pattern molecules (DAMPs) that activate the mannan-binding lectin (MBL) pathway of the ComC, from cells of the innate immunity network.	Adenosine Triphosphate	30-33	interleukin 1 beta	Mus musculus	113-130
31214026-0	2019	Nobiletin Inhibits IL-1beta-Induced Inflammation in Chondrocytes via Suppression of NF-kappaB Signaling and Attenuates Osteoarthritis in Mice.	nobiletin	0-9	interleukin 1 beta	Mus musculus	19-27
31214026-9	2019	Induction of proinflammatory and catabolic mediators by IL-1beta stimulation of mouse chondrocytes could be partially blocked by treatment with nobiletin or ammonium pyrrolidine dithiocarbamate (an NF-kappaB inhibitor).	nobiletin	144-153	interleukin 1 beta	Mus musculus	56-64
31214026-9	2019	Induction of proinflammatory and catabolic mediators by IL-1beta stimulation of mouse chondrocytes could be partially blocked by treatment with nobiletin or ammonium pyrrolidine dithiocarbamate (an NF-kappaB inhibitor).	pyrrolidine dithiocarbamic acid	157-193	interleukin 1 beta	Mus musculus	56-64
31140426-5	2019	RESULTS: Quercetin significantly lessened renal pathologies, lowered BUN and creatinine levels (P &amp;lt; 0.05) and inhibited TNF-alpha, IL-1beta, and IL-6 production in mice with LPS-induced AKI (P &amp;lt; 0.05).	Quercetin	9-18	interleukin 1 beta	Mus musculus	138-146
31160894-15	2019	Rosiglitazone significantly ameliorated the lung injury, decreasing the TNF-alpha and IL-1beta levels in the BALF, enhancing AFC, and promoting the expressions of alphaENaC and SGK1 in ALI mice, which were abolished by the specific PPARgamma blocker GW9662.	Rosiglitazone	0-13	interleukin 1 beta	Mus musculus	86-94
30806957-2	2019	Trehalose-6,6"-dibehenate (TDB) displays moderate anti-tumour activity and stimulates M1-like macrophages via the macrophage inducible C-type lectin (Mincle) resulting in IL-1beta production.	trehalose 6,6'-dibehenate	0-25	interleukin 1 beta	Mus musculus	171-179
30806957-2	2019	Trehalose-6,6"-dibehenate (TDB) displays moderate anti-tumour activity and stimulates M1-like macrophages via the macrophage inducible C-type lectin (Mincle) resulting in IL-1beta production.	trehalose 6,6'-dibehenate	27-30	interleukin 1 beta	Mus musculus	171-179
30806957-3	2019	In this study, we examined if monosodium urate (MSU), a known vaccine adjuvant, can boost IL-1beta production by TDB-stimulated macrophages.	Uric Acid	30-46	interleukin 1 beta	Mus musculus	90-98
30806957-3	2019	In this study, we examined if monosodium urate (MSU), a known vaccine adjuvant, can boost IL-1beta production by TDB-stimulated macrophages.	Uric Acid	48-51	interleukin 1 beta	Mus musculus	90-98
30806957-3	2019	In this study, we examined if monosodium urate (MSU), a known vaccine adjuvant, can boost IL-1beta production by TDB-stimulated macrophages.	trehalose 6,6'-dibehenate	113-116	interleukin 1 beta	Mus musculus	90-98
30979498-7	2019	Mechanistically, we showed that the contribution of vx-765 to ischemic injuries may be associated with reducing microglial activation, and downregulating the production of associated pro inflammatory cytokines including IL-1beta, TNF-alpha, and iNOS, as well as upregulating anti-inflammatory cytokines such as TGF-beta and YM-1.	belnacasan	52-58	interleukin 1 beta	Mus musculus	220-228
30117046-4	2019	Compared to LF, Cu-supplemented LF product of lower Cu-supplementation content at lower dose level yielded slightly enhanced macrophage stimulation, increased CD4+/CD8+ ratio of T lymphocyte subpopulations in ConA-stimulated splenocytes, and significant secretion enhancement for interleukin-2 (IL-2), IL-4, interferon-gamma (in splenocytes), IL-1beta, and tumor necrosis factor-alpha (in macrophages) (P &amp;lt; 0.05).	Copper	16-18	interleukin 1 beta	Mus musculus	343-351
31191309-10	2019	The percentage of M1-phenotype cells as well as the mRNA levels of iNOS, TNF-alpha, IL-1beta, and MCP-1 were downregulated when PF-treated polarized macrophages were cultured under conditions of high glucose (HG) levels.	peoniflorin	128-130	interleukin 1 beta	Mus musculus	84-92
31141940-7	2019	Moreover, honokiol ameliorated LPS-induced NF-kappaB activation in the hippocampus and significantly reduced the levels of the pro-inflammatory cytokines; tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), and interferon gamma (IFN-gamma).	honokiol	10-18	interleukin 1 beta	Mus musculus	196-213
30802614-4	2019	Results indicate that SOL at the concentration range from 25 to 100 mug/mL and its main components, chlorogenic acid, caffeic acid (25-100 muM) significantly reduced the pro-inflammatory cytokine IL-1beta, IL-6, TNF-alpha, attenuated iNOS and COX-2 expression in LPS-stimulated Macrophages.	Chlorogenic Acid	100-116	interleukin 1 beta	Mus musculus	196-204
30802614-4	2019	Results indicate that SOL at the concentration range from 25 to 100 mug/mL and its main components, chlorogenic acid, caffeic acid (25-100 muM) significantly reduced the pro-inflammatory cytokine IL-1beta, IL-6, TNF-alpha, attenuated iNOS and COX-2 expression in LPS-stimulated Macrophages.	caffeic acid	118-130	interleukin 1 beta	Mus musculus	196-204
30753846-7	2019	The elevation of serum and prefrontal cortex pro-inflammatory cytokines including interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) was decreased by macranthol pretreatment.	macranthol	194-204	interleukin 1 beta	Mus musculus	82-99
31156650-11	2019	This suggestion was supported by the observations that paclitaxel treatment caused robust IL-1beta production in macrophages in the presence of cell-free medium derived from growth of injured cells and also in the spleen of mice.	Paclitaxel	55-65	interleukin 1 beta	Mus musculus	90-98
30825859-5	2019	Amodiaquine also suppressed ICH-induced mRNA expression of IL-1beta, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.	Amodiaquine	0-11	interleukin 1 beta	Mus musculus	59-67
30935688-7	2019	The current results showed that metformin activated autophagy and decreased the mRNA expressions of inflammatory cytokines, IL-1beta, IL-6, and TNF-alpha via inhibition of the STAT3 mRNA and protein expression.	Metformin	32-41	interleukin 1 beta	Mus musculus	124-132
31171272-3	2019	We discovered that Broussonin E could suppress the LPS-induced pro-inflammatory production in RAW264.7 cells, involving TNF-alpha, IL-1beta, IL-6, COX-2 and iNOS.	broussonin E	19-31	interleukin 1 beta	Mus musculus	131-139
31097691-8	2019	GSK1016790A also increased proinflammatory cytokine IL-1beta, TNF-alpha and IL-6 protein levels, which were blocked by caspase-1 inhibitor Ac-YVAD-cmk.	N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide	0-11	interleukin 1 beta	Mus musculus	52-60
31097691-8	2019	GSK1016790A also increased proinflammatory cytokine IL-1beta, TNF-alpha and IL-6 protein levels, which were blocked by caspase-1 inhibitor Ac-YVAD-cmk.	N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone	139-150	interleukin 1 beta	Mus musculus	52-60
30946805-4	2019	Our in vitro study identified that pretreatment of dauricine dose-dependently inhibited pro-inflammatory cytokines including nitric oxide (NO), interleukin-1beta (IL1beta), IL6, tumor necrosis factor-alpha (TNFalpha), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX2) in LPS-stimulated macrophages.	dauricine	51-60	interleukin 1 beta	Mus musculus	144-161
30753846-7	2019	The elevation of serum and prefrontal cortex pro-inflammatory cytokines including interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) was decreased by macranthol pretreatment.	macranthol	194-204	interleukin 1 beta	Mus musculus	101-109
30896160-5	2019	The nitro-substituted quinazolin-4(3 H)-one 2k inhibited NLRP3 inflammasome (IC50 5 muM) via the suppression of IL-1beta release from ATP-stimulated J774A.1 cells.	nitro	4-9	interleukin 1 beta	Mus musculus	112-120
31068207-9	2019	RESULTS: The administration of baicalin (especially 60 mg/kg) dramatically ameliorated CUMS-induced depressive-like symptoms; substantially decreased the levels of interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) in the hippocampus; and significantly decreased the expression of TLR4.	baicalin	31-39	interleukin 1 beta	Mus musculus	164-182
31068207-9	2019	RESULTS: The administration of baicalin (especially 60 mg/kg) dramatically ameliorated CUMS-induced depressive-like symptoms; substantially decreased the levels of interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) in the hippocampus; and significantly decreased the expression of TLR4.	baicalin	31-39	interleukin 1 beta	Mus musculus	184-192
30896160-5	2019	The nitro-substituted quinazolin-4(3 H)-one 2k inhibited NLRP3 inflammasome (IC50 5 muM) via the suppression of IL-1beta release from ATP-stimulated J774A.1 cells.	quinazolin-4(3 h)-one	22-43	interleukin 1 beta	Mus musculus	112-120
30896160-5	2019	The nitro-substituted quinazolin-4(3 H)-one 2k inhibited NLRP3 inflammasome (IC50 5 muM) via the suppression of IL-1beta release from ATP-stimulated J774A.1 cells.	Adenosine Triphosphate	134-137	interleukin 1 beta	Mus musculus	112-120
30686117-3	2019	The expression of IL-1beta, IL-6 and TNF-alpha in both serum and supernate were reduced in miR-125b over-expression groups.	mir-125b	91-99	interleukin 1 beta	Mus musculus	18-26
30682503-3	2019	Treatment of cultured spinal astrocytes with specific REV-ERBs agonists SR9009 or GSK4112 significantly prevented lipopolysaccharide (LPS)-induced mRNA upregulation of pronociceptive molecules interleukin-1beta (IL-1beta) mRNA, interleukin-6 (IL-6) mRNA and matrix metalloprotease-9 (MMP-9) mRNA, but not CCL2 mRNA expression.	GSK4112	82-89	interleukin 1 beta	Mus musculus	193-210
30682503-3	2019	Treatment of cultured spinal astrocytes with specific REV-ERBs agonists SR9009 or GSK4112 significantly prevented lipopolysaccharide (LPS)-induced mRNA upregulation of pronociceptive molecules interleukin-1beta (IL-1beta) mRNA, interleukin-6 (IL-6) mRNA and matrix metalloprotease-9 (MMP-9) mRNA, but not CCL2 mRNA expression.	GSK4112	82-89	interleukin 1 beta	Mus musculus	212-220
30988740-9	2019	Furthermore, in the mouse model of KD, AUDA reduced the protein expression of MMP-9, IL-1beta and TNF-alpha, indicating that AUDA may alleviate inflammatory reactions in the coronary arteries of KD model mice.	12-(3-adamantan-1-ylureido)dodecanoic acid	39-43	interleukin 1 beta	Mus musculus	85-93
30776316-2	2019	ATP is essential for the release of nonclassically secreted cytokines such as IL-1beta but, paradoxically, has been reported to inhibit the release of classically secreted cytokines such as TNF.	Adenosine Triphosphate	0-3	interleukin 1 beta	Mus musculus	78-86
31007758-2	2019	The present study was undertaken to determine the suppressive effects of (+)-catechin, baicalin or beta-caryophyllene on the production of inflammatory cytokines, including TNF-alpha, IL-6 and IL-1beta, which was enhanced by lipopolysaccharide (LPS) in RAW264.7 cells in vitro.	Catechin	73-85	interleukin 1 beta	Mus musculus	193-201
31007758-2	2019	The present study was undertaken to determine the suppressive effects of (+)-catechin, baicalin or beta-caryophyllene on the production of inflammatory cytokines, including TNF-alpha, IL-6 and IL-1beta, which was enhanced by lipopolysaccharide (LPS) in RAW264.7 cells in vitro.	caryophyllene	99-117	interleukin 1 beta	Mus musculus	193-201
30988740-9	2019	Furthermore, in the mouse model of KD, AUDA reduced the protein expression of MMP-9, IL-1beta and TNF-alpha, indicating that AUDA may alleviate inflammatory reactions in the coronary arteries of KD model mice.	12-(3-adamantan-1-ylureido)dodecanoic acid	125-129	interleukin 1 beta	Mus musculus	85-93
30874868-5	2019	RESULTS: In mice with AR, AST2017-01 and chrysophanol markedly decreased number of rubs, IgE, histamine, thymic stromal lymphopoietin, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-4, IL-5, and IL-13 in serum or nasal mucosa tissues.	chrysophanic acid	41-53	interleukin 1 beta	Mus musculus	164-186
30896805-0	2019	Peimine suppresses interleukin-1beta-induced inflammation via MAPK downregulation in chondrocytes.	verticine	0-7	interleukin 1 beta	Mus musculus	19-36
30851708-0	2019	Taraxasterol suppresses inflammation in IL-1beta-induced rheumatoid arthritis fibroblast-like synoviocytes and rheumatoid arthritis progression in mice.	taraxasterol	0-12	interleukin 1 beta	Mus musculus	40-48
30798158-7	2019	RESULTS: C57BL/6 mice treated with CLT from 1 day post infection showed decreased disease, IL-1beta, TNF-alpha, IL-10, TGF-beta, MIP-2 and LOX-1 levels.	celastrol	35-38	interleukin 1 beta	Mus musculus	91-99
30896805-4	2019	The data revealed that Peimine not only suppressed IL-1beta-induced production of nitric oxide (NO) and prostaglandin E2, but also reduced the protein levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2).	verticine	23-30	interleukin 1 beta	Mus musculus	51-59
30896805-4	2019	The data revealed that Peimine not only suppressed IL-1beta-induced production of nitric oxide (NO) and prostaglandin E2, but also reduced the protein levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2).	Nitric Oxide	82-94	interleukin 1 beta	Mus musculus	51-59
30802677-7	2019	MCC950 treatment significantly alleviated BDL-induced liver injury by reducing production of the pro-inflammatory cytokines IL-1beta and IL-18 and inhibiting neutrophil infiltration and hepatic cell death.	N-(biphenyl-4-ylsulfonyl)-D-leucine	42-45	interleukin 1 beta	Mus musculus	124-132
30896805-4	2019	The data revealed that Peimine not only suppressed IL-1beta-induced production of nitric oxide (NO) and prostaglandin E2, but also reduced the protein levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2).	Dinoprostone	104-120	interleukin 1 beta	Mus musculus	51-59
30896805-5	2019	In addition, Peimine inhibited the IL-1beta-induced mRNA expression of matrix metalloproteinase (MMP)-1, MMP-3, MMP-9, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4 and ADAMTS-5.	verticine	13-20	interleukin 1 beta	Mus musculus	35-43
30896805-6	2019	Furthermore, Peimine inhibited IL-1beta-induced activation of the mitogen-activated protein kinase (MAPK) pathway.	verticine	13-20	interleukin 1 beta	Mus musculus	31-39
30896805-7	2019	The protective effect of Peimine on IL-1beta-treated chondrocytes was attenuated following activation of the MAPK pathway, as demonstrated by the increased expression levels of MMP-3, MMP-13, ADAMTS-5, iNOS and COX-2 compared with the Peimine group.	verticine	25-32	interleukin 1 beta	Mus musculus	36-44
30896805-9	2019	In general, the data indicate that Peimine suppresses IL-1beta-induced inflammation in mouse chondrocytes by inhibiting the MAPK pathway, suggesting a promising therapeutic role for Peimine in the treatment of OA.	verticine	35-42	interleukin 1 beta	Mus musculus	54-62
30896805-9	2019	In general, the data indicate that Peimine suppresses IL-1beta-induced inflammation in mouse chondrocytes by inhibiting the MAPK pathway, suggesting a promising therapeutic role for Peimine in the treatment of OA.	verticine	182-189	interleukin 1 beta	Mus musculus	54-62
30617549-6	2019	Mice treated with resveratrol, quercetin, or gallic acid produced a 40%, 40%, and 30% reduction of the edema, respectively, while mice treated with resveratrol or gallic acid produced a 50 and 45% reduction in IL-1beta, also respectively, and a 35% reduction in MPO.	Resveratrol	18-29	interleukin 1 beta	Mus musculus	210-218
30864870-11	2019	Substance P and cytokines such as interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) were also attenuated with BCP administration.	caryophyllene	156-159	interleukin 1 beta	Mus musculus	34-51
30864870-11	2019	Substance P and cytokines such as interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6) were also attenuated with BCP administration.	caryophyllene	156-159	interleukin 1 beta	Mus musculus	53-61
30151726-4	2019	Our in vitro findings demonstrated that exposure of pericytes to cocaine resulted in upregulation of the pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) in both the intracellular as well as extracellular compartments, thus underpinning pericytes as yet another source of neuroinflammation.	Cocaine	65-72	interleukin 1 beta	Mus musculus	144-152
30794846-9	2019	For inflammatory response, PG treatment inhibited inflammatory cytokines releasing, such as TNF-alpha, IFN-gamma, IL-1beta, IL-6, IL-12, IL-17, and IL-23.	propagermanium	27-29	interleukin 1 beta	Mus musculus	114-122
30617549-6	2019	Mice treated with resveratrol, quercetin, or gallic acid produced a 40%, 40%, and 30% reduction of the edema, respectively, while mice treated with resveratrol or gallic acid produced a 50 and 45% reduction in IL-1beta, also respectively, and a 35% reduction in MPO.	Gallic Acid	45-56	interleukin 1 beta	Mus musculus	210-218
30617549-6	2019	Mice treated with resveratrol, quercetin, or gallic acid produced a 40%, 40%, and 30% reduction of the edema, respectively, while mice treated with resveratrol or gallic acid produced a 50 and 45% reduction in IL-1beta, also respectively, and a 35% reduction in MPO.	Resveratrol	148-159	interleukin 1 beta	Mus musculus	210-218
30617549-6	2019	Mice treated with resveratrol, quercetin, or gallic acid produced a 40%, 40%, and 30% reduction of the edema, respectively, while mice treated with resveratrol or gallic acid produced a 50 and 45% reduction in IL-1beta, also respectively, and a 35% reduction in MPO.	Gallic Acid	163-174	interleukin 1 beta	Mus musculus	210-218
31060676-3	2019	Results After treatment with H2O2,the expression of caspase-1 protein and NLRP3 mRNA in BV2 cells was increased,and IL-1beta protein in BV2 cells was significantly increased after treatment with GdCl3(P=0.0036).After treatment with CA-074Me,the doses of NLRP3 mRNA(P=0.037),caspase-1(P=0.021),and IL-1beta(P= 0.036)were significantly reduced.Cells in the H2O2 group and H2O2+GdCl3 group grew more slowly.The expressions of CTSB mRNA and TRPML1 mRNA,or CTSB and TRPML1 proteins in BV2 cells in the treatment group with 200 mumol/L of H2O2 concentration were similar.H2O2-induced CTSB protein expression was inhibited after silencing TRPML1 gene.The changes of other cathepsins were not affected for the different concentration of H2O2.In the BV2 cells treated with TRPML1 gene silencing,the expression of CTSB protein was significantly reduced and the difference was statistically significant(P=0.021)between the H2O2 +siRNA treatment group and the H2O2 treatment group.&lt;b&gt;Conclusion&lt;/b&gt; CTSB regulates the activation of NLRP3 inflammasome in the oxidative stress model of microglia cells,probably mediated by calcium channel protein TRPML1.	Hydrogen Peroxide	29-33	interleukin 1 beta	Mus musculus	116-124
30848526-7	2019	Moreover, in lipopolysaccharides-induced BV-2 cells, the levels of inflammatory factors (IL-1beta), p65 acetylation at lysine 310, and SIRT1 expression were different in the group treated with both baicalin and nicotinamide compared with the group treated with baicalin, which suggests that baicalin regulates SIRT1 and thereby inhibits p65 acetylation.	baicalin	198-206	interleukin 1 beta	Mus musculus	89-97
31073286-5	2019	Histological and immunohistochemical staining results revealed that GA treatment suppressed overexpressions of pro-inflammatory cytokines of IL-1 beta and TNF-alpha in the brain of C57 mice by inhibiting toll-like receptor 4 (TLR4) signaling pathway activation.	Glycyrrhizic Acid	68-70	interleukin 1 beta	Mus musculus	141-150
31060676-3	2019	Results After treatment with H2O2,the expression of caspase-1 protein and NLRP3 mRNA in BV2 cells was increased,and IL-1beta protein in BV2 cells was significantly increased after treatment with GdCl3(P=0.0036).After treatment with CA-074Me,the doses of NLRP3 mRNA(P=0.037),caspase-1(P=0.021),and IL-1beta(P= 0.036)were significantly reduced.Cells in the H2O2 group and H2O2+GdCl3 group grew more slowly.The expressions of CTSB mRNA and TRPML1 mRNA,or CTSB and TRPML1 proteins in BV2 cells in the treatment group with 200 mumol/L of H2O2 concentration were similar.H2O2-induced CTSB protein expression was inhibited after silencing TRPML1 gene.The changes of other cathepsins were not affected for the different concentration of H2O2.In the BV2 cells treated with TRPML1 gene silencing,the expression of CTSB protein was significantly reduced and the difference was statistically significant(P=0.021)between the H2O2 +siRNA treatment group and the H2O2 treatment group.&lt;b&gt;Conclusion&lt;/b&gt; CTSB regulates the activation of NLRP3 inflammasome in the oxidative stress model of microglia cells,probably mediated by calcium channel protein TRPML1.	gadolinium chloride	195-200	interleukin 1 beta	Mus musculus	116-124
31060676-3	2019	Results After treatment with H2O2,the expression of caspase-1 protein and NLRP3 mRNA in BV2 cells was increased,and IL-1beta protein in BV2 cells was significantly increased after treatment with GdCl3(P=0.0036).After treatment with CA-074Me,the doses of NLRP3 mRNA(P=0.037),caspase-1(P=0.021),and IL-1beta(P= 0.036)were significantly reduced.Cells in the H2O2 group and H2O2+GdCl3 group grew more slowly.The expressions of CTSB mRNA and TRPML1 mRNA,or CTSB and TRPML1 proteins in BV2 cells in the treatment group with 200 mumol/L of H2O2 concentration were similar.H2O2-induced CTSB protein expression was inhibited after silencing TRPML1 gene.The changes of other cathepsins were not affected for the different concentration of H2O2.In the BV2 cells treated with TRPML1 gene silencing,the expression of CTSB protein was significantly reduced and the difference was statistically significant(P=0.021)between the H2O2 +siRNA treatment group and the H2O2 treatment group.&lt;b&gt;Conclusion&lt;/b&gt; CTSB regulates the activation of NLRP3 inflammasome in the oxidative stress model of microglia cells,probably mediated by calcium channel protein TRPML1.	Hydrogen Peroxide	29-33	interleukin 1 beta	Mus musculus	297-305
31060676-3	2019	Results After treatment with H2O2,the expression of caspase-1 protein and NLRP3 mRNA in BV2 cells was increased,and IL-1beta protein in BV2 cells was significantly increased after treatment with GdCl3(P=0.0036).After treatment with CA-074Me,the doses of NLRP3 mRNA(P=0.037),caspase-1(P=0.021),and IL-1beta(P= 0.036)were significantly reduced.Cells in the H2O2 group and H2O2+GdCl3 group grew more slowly.The expressions of CTSB mRNA and TRPML1 mRNA,or CTSB and TRPML1 proteins in BV2 cells in the treatment group with 200 mumol/L of H2O2 concentration were similar.H2O2-induced CTSB protein expression was inhibited after silencing TRPML1 gene.The changes of other cathepsins were not affected for the different concentration of H2O2.In the BV2 cells treated with TRPML1 gene silencing,the expression of CTSB protein was significantly reduced and the difference was statistically significant(P=0.021)between the H2O2 +siRNA treatment group and the H2O2 treatment group.&lt;b&gt;Conclusion&lt;/b&gt; CTSB regulates the activation of NLRP3 inflammasome in the oxidative stress model of microglia cells,probably mediated by calcium channel protein TRPML1.	gadolinium chloride	195-200	interleukin 1 beta	Mus musculus	297-305
31068895-6	2019	Results: In the injured neonatal brain, remifentanil significantly decreased ROS production, cortical caspase activity, DNA fragmentation, interleukin-1beta levels, and reactive astrogliosis.	Remifentanil	40-52	interleukin 1 beta	Mus musculus	139-156
31068805-14	2019	We also found the mRNA levels of TNF-alpha, IL-1beta, IL-6 and NF-kappaBp65 were down-regulate after 7 days from the LMZ treatment compared to CFA group.	3-chloro-4-fluoroaniline	143-146	interleukin 1 beta	Mus musculus	44-52
30833334-4	2019	A DeltamroQ mutant exhibited impaired induction of Toll-like receptor 2-dependent inflammatory responses from macrophages but elicited greater production of the inflammatory cytokine interleukin-1beta and was attenuated in a murine skin and soft tissue infection model.	deltamroq	2-11	interleukin 1 beta	Mus musculus	183-200
31275508-8	2019	The pan-caspase inhibitor nivocasan potently reduced not only inflammasome-mediated interleukin-1beta (IL-1beta) secretion but also osteoclast differentiation in BMMs.	NIVOCASAN	26-35	interleukin 1 beta	Mus musculus	84-101
31011151-10	2019	Moreover, Mx1 and its related proinflamatory genes (Mx2, Il1b, and Tnf) were also up-regulated in poly I:C-treated mice.	Poly I	98-104	interleukin 1 beta	Mus musculus	57-61
31011151-10	2019	Moreover, Mx1 and its related proinflamatory genes (Mx2, Il1b, and Tnf) were also up-regulated in poly I:C-treated mice.	Carbon	105-106	interleukin 1 beta	Mus musculus	57-61
30876876-5	2019	Commensal-IgG immune complexes engaged gut-resident FcgammaR-expressing macrophages, inducing NLRP3- and reactive-oxygen-species-dependent production of interleukin-1beta (IL-1beta) and neutrophil-recruiting chemokines.	Oxygen	114-120	interleukin 1 beta	Mus musculus	153-170
31057373-7	2019	Compared to 129sv mice, CUS induced higher levels of systemic, frontal cortex and hippocampal corticosterone, and also reduced sucrose preference, increased levels of splenic IL-1beta, IL-17 and PGE2 and reduced levels of LTB4.	cus	24-27	interleukin 1 beta	Mus musculus	175-183
30876876-5	2019	Commensal-IgG immune complexes engaged gut-resident FcgammaR-expressing macrophages, inducing NLRP3- and reactive-oxygen-species-dependent production of interleukin-1beta (IL-1beta) and neutrophil-recruiting chemokines.	Oxygen	114-120	interleukin 1 beta	Mus musculus	172-180
31097920-7	2019	In addition, after blocking CD36 with inhibitor sulfo-N-succinimidyl oleate (SSO) or CD36 siRNA, activation of NLRP3 inflammasome and release of IL-1beta are downregulated, and podocyte injury was alleviated.	sulfo-N-succinimidyl oleate	48-75	interleukin 1 beta	Mus musculus	145-153
31178949-6	2019	The results revealed that MC elicited hepatotoxicity and neurotoxicity which was evident due to the significant elevation of serum AST, ALT, gammaGT, ALP, LDH, IL-1beta, IL-6, and TNF-alpha levels.	Methylcholanthrene	26-28	interleukin 1 beta	Mus musculus	160-168
30716318-8	2019	In addition, immunohistochemistry staining and western blot analysis indicated that harmine treatment suppressed the expression of toll-like receptor 4 (TLR4) and the phosphorylation of nuclear factor-kappa B (NF-kappaB) p65 and inhibitor of kappaBalpha (IkappaBalpha) while inhibiting the expression of NLRP3, caspase-1 and interleukin-1beta (IL-1beta).	Harmine	84-91	interleukin 1 beta	Mus musculus	325-342
30716318-8	2019	In addition, immunohistochemistry staining and western blot analysis indicated that harmine treatment suppressed the expression of toll-like receptor 4 (TLR4) and the phosphorylation of nuclear factor-kappa B (NF-kappaB) p65 and inhibitor of kappaBalpha (IkappaBalpha) while inhibiting the expression of NLRP3, caspase-1 and interleukin-1beta (IL-1beta).	Harmine	84-91	interleukin 1 beta	Mus musculus	344-352
31097920-7	2019	In addition, after blocking CD36 with inhibitor sulfo-N-succinimidyl oleate (SSO) or CD36 siRNA, activation of NLRP3 inflammasome and release of IL-1beta are downregulated, and podocyte injury was alleviated.	sulfo-N-succinimidyl oleate	77-80	interleukin 1 beta	Mus musculus	145-153
30784929-15	2019	This was different from the IL-1beta levels that were higher in the control groups (GS and GMS).	gms	91-94	interleukin 1 beta	Mus musculus	28-36
30971286-9	2019	RESULTS: Repeated NTG administration induced acute and chronic mechanical hyperalgesia and increased expression of NLRP3 and IL-1beta.	Nitroglycerin	18-21	interleukin 1 beta	Mus musculus	125-133
30971286-10	2019	Blockade of NLRP3 or IL-1beta reduced NTG-induced hyperalgesia, and this effect was accompanied by a significant inhibition of the NTG-induced increase in p-ERK, c-Fos and CGRP levels in the TNC.	Nitroglycerin	38-41	interleukin 1 beta	Mus musculus	21-29
30971286-10	2019	Blockade of NLRP3 or IL-1beta reduced NTG-induced hyperalgesia, and this effect was accompanied by a significant inhibition of the NTG-induced increase in p-ERK, c-Fos and CGRP levels in the TNC.	Nitroglycerin	131-134	interleukin 1 beta	Mus musculus	21-29
31024256-12	2019	Treatment with GUDCA or VS led to a decrease of TNF-alpha, IL-1beta, HMGB1, S100B and miR-155 in hSOD1G93A microglia.	glycoursodeoxycholic acid	15-20	interleukin 1 beta	Mus musculus	59-67
30773464-7	2019	Pharmacological inhibition of de novo serine synthesis in vivo decreased LPS induction of IL-1beta levels and improved survival in an LPS-driven model of sepsis in mice.	Serine	38-44	interleukin 1 beta	Mus musculus	90-98
30216538-7	2019	When STZ was injected to induce diabetes in mice, neither hyperglycemia nor hypoinsulinemia was developed in agomelatine pretreated mice and 6 weeks after development of diabetes, agomelatine treatment significantly decreased levels of IL-1beta mRNA in raphe nucleus and nucleus accumbens.	Streptozocin	5-8	interleukin 1 beta	Mus musculus	236-244
30818140-9	2019	Furthermore, shikonin markedly attenuated the APAP-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) and suppressed the expression of genes related to inflammation.	shikonin	13-21	interleukin 1 beta	Mus musculus	140-157
30818140-9	2019	Furthermore, shikonin markedly attenuated the APAP-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) and suppressed the expression of genes related to inflammation.	shikonin	13-21	interleukin 1 beta	Mus musculus	159-167
30818140-9	2019	Furthermore, shikonin markedly attenuated the APAP-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) and suppressed the expression of genes related to inflammation.	Acetaminophen	46-50	interleukin 1 beta	Mus musculus	140-157
30818140-9	2019	Furthermore, shikonin markedly attenuated the APAP-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) and suppressed the expression of genes related to inflammation.	Acetaminophen	46-50	interleukin 1 beta	Mus musculus	159-167
30707759-11	2019	In cultured cardiomyocytes, clozapine increased the pro-inflammatory factor IL-1beta and the concentrations of myocardial injury markers (LDH and aspartate aminotransferase); these effects were reversed by either a CB1 antagonist or CB2 agonist and further prevented by combined pretreatments.	Clozapine	28-37	interleukin 1 beta	Mus musculus	76-84
30707890-6	2019	NMDA insult in the retina potentiates macrophage/microglia cell infiltration, primes the NLRP3 inflammasome in a transcription-dependent manner and induces the expression of interleukin-1beta (IL-1beta).	N-Methylaspartate	0-4	interleukin 1 beta	Mus musculus	174-191
30707890-6	2019	NMDA insult in the retina potentiates macrophage/microglia cell infiltration, primes the NLRP3 inflammasome in a transcription-dependent manner and induces the expression of interleukin-1beta (IL-1beta).	N-Methylaspartate	0-4	interleukin 1 beta	Mus musculus	193-201
30216538-7	2019	When STZ was injected to induce diabetes in mice, neither hyperglycemia nor hypoinsulinemia was developed in agomelatine pretreated mice and 6 weeks after development of diabetes, agomelatine treatment significantly decreased levels of IL-1beta mRNA in raphe nucleus and nucleus accumbens.	agomelatine	180-191	interleukin 1 beta	Mus musculus	236-244
30826410-5	2019	Additionally, ginsenoside Rk3 significantly reduced the expression of inflammatory cytokines, such as NF-kappaB, TNF-alpha, IL-6, and IL-1beta in the mice.	Ginsenosides	14-25	interleukin 1 beta	Mus musculus	134-142
30769049-5	2019	In particular, aloin induced translocation of Nrf2 from cytosol into the nucleus by an increased Nrf2-ARE binding activity, and reduced IL-1beta production in LPS-activated HUVECs.	alloin	15-20	interleukin 1 beta	Mus musculus	136-144
30942801-0	2019	Peiminine inhibits the IL-1beta induced inflammatory response in mouse articular chondrocytes and ameliorates murine osteoarthritis.	peiminine	0-9	interleukin 1 beta	Mus musculus	23-31
30942801-6	2019	IL-1beta-induced expression of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6) were all inhibited significantly by Pm pretreatment in vitro.	Nitric Oxide	31-43	interleukin 1 beta	Mus musculus	0-8
30506106-4	2019	BCI treatment inhibited LPS-triggered inflammatory cytokine production, including IL-1beta and IL-6, but not TNF-alpha, and also affected macrophage polarization to an M1 phenotype.	(E)-2-Benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one	0-3	interleukin 1 beta	Mus musculus	82-90
30942801-6	2019	IL-1beta-induced expression of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6) were all inhibited significantly by Pm pretreatment in vitro.	Dinoprostone	50-66	interleukin 1 beta	Mus musculus	0-8
30942801-6	2019	IL-1beta-induced expression of nitric oxide (NO), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-alpha), inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6) were all inhibited significantly by Pm pretreatment in vitro.	Dinoprostone	68-72	interleukin 1 beta	Mus musculus	0-8
30343389-10	2019	TQ inhibited plasma cTnT levels; improved ATP; significantly inhibited p62, NLRP3, caspase-1, IL-1beta, IL-18, IL-6, TNF-alpha, and MCP-1expressions; and increased beclin 1 and IL-10 level.	thymoquinone	0-2	interleukin 1 beta	Mus musculus	94-102
30743203-5	2019	It was found that genistein can significantly improve IMQ-induced pathological scores of cutaneous skin lesions in mice, reduce epidermal thickness, and inhibit the expression of inflammatory factors,including interleukin (IL)-1beta, IL-6, tumour necrosis factor-alpha (TNF-alpha), chemokine ligand 2 (CCL2), IL-17 and IL-23.	Genistein	18-27	interleukin 1 beta	Mus musculus	210-232
30506107-7	2019	Overexpression of miR-17-5p suppressed the concentrations of inflammatory factors (IL-1beta and TNF-alpha) in LPS induced-macrophages, while pcDNA-TLR4 could change the inhibition effect.	mir-17-5p	18-27	interleukin 1 beta	Mus musculus	83-91
30506107-8	2019	Additionally, miR-17-5p inhibitor changed the inhibitory effects of Sch B on TLR4 expression and the concentrations of IL-1beta and TNF-alpha in LPS induced-macrophages.	mir-17-5p	14-23	interleukin 1 beta	Mus musculus	119-127
30716587-6	2019	Intraperitoneal injection of fraxinellone significantly inhibited the pancreatic activation of multiple inflammasome molecules such as NACHT, LRR and PYD domains-containing protein 3 (NLRP3), PY-CARD, caspase-1, IL-18, and IL-1beta during AP.	fraxinellone	29-41	interleukin 1 beta	Mus musculus	223-231
30720093-4	2019	In addition, the present results suggested that puerarin suppressed the interleukin-1beta-induced production of inflammatory cytokines in OA chondrocytes and monocytes/macrophages, as assessed by ELISA.	puerarin	48-56	interleukin 1 beta	Mus musculus	72-89
30763157-0	2019	Microparticle-induced vascular injury in mice following decompression is inhibited by hyperbaric oxygen: effects on microparticles and interleukin-1beta.	Oxygen	97-103	interleukin 1 beta	Mus musculus	135-152
30791996-6	2019	High glucose and palmitic acid treatment enhanced the expression of interleukin-1beta and interleukin-18; these enhancements were further increased after treatment with DsbA-L siRNA but alleviated by co-treatment with an AMPK activator.	Glucose	5-12	interleukin 1 beta	Mus musculus	68-85
30791996-6	2019	High glucose and palmitic acid treatment enhanced the expression of interleukin-1beta and interleukin-18; these enhancements were further increased after treatment with DsbA-L siRNA but alleviated by co-treatment with an AMPK activator.	Palmitic Acid	17-30	interleukin 1 beta	Mus musculus	68-85
30632500-9	2019	Expression of Iba1, tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 was significantly lower in the acacetin group compared with the middle cerebral artery occlusion group.	acacetin	116-124	interleukin 1 beta	Mus musculus	49-66
30802715-11	2019	RESULTS: Ha-EtOAc inhibited the LPS-induced production of NO and decreased the release of TNF-alpha, IL-6 and IL-1beta in RAW264.7 cells in a dose-dependent manner.	histidinoalanine	9-11	interleukin 1 beta	Mus musculus	110-118
30802715-11	2019	RESULTS: Ha-EtOAc inhibited the LPS-induced production of NO and decreased the release of TNF-alpha, IL-6 and IL-1beta in RAW264.7 cells in a dose-dependent manner.	ethyl acetate	12-17	interleukin 1 beta	Mus musculus	110-118
31049133-7	2019	Simultaneously, sulforaphane-enriched broccoli sprouts inhibited the LPS-induced activation of the NF-kappaB signaling pathway and the secretions of inflammatory proteins (iNOS, COX-2, TNF-alpha, IL-6, IL-1beta, PGE2, etc.	sulforaphane	16-28	interleukin 1 beta	Mus musculus	202-210
31049025-9	2019	We also observed the inhibition of IkappaBalpha degradation by vinpocetine, which demonstrates a reduction in the activation of NF-kappaB explaining the diminished production of IL-33, IL-1beta, and TNF-alpha.	vinpocetine	63-74	interleukin 1 beta	Mus musculus	185-193
31049358-2	2019	Early production of TNF-alpha, IL-1beta, and IL-6 in the liver after DEN treatment correlated with tumor development in AIRmax mice.	Diethylnitrosamine	69-72	interleukin 1 beta	Mus musculus	31-39
30710049-1	2019	LPS-activated macrophages require metabolic reprogramming and glucose uptake mediated by hypoxia-inducible factor (HIF)-1 alpha and glucose transporter 1 (Glut1) expression for proinflammatory cytokine production, especially IL-1beta.	Glucose	62-69	interleukin 1 beta	Mus musculus	225-233
30971927-3	2019	We uncovered that evodiamine dose-dependently enhanced NLRP3 inflammasome activation in lipopolysaccharide-primed macrophages, as indicated by increased interleukin (IL)-1beta production and caspase-1 cleavage, accompanied by increased ASC speck formation and pyroptosis.	evodiamine	18-28	interleukin 1 beta	Mus musculus	153-175
30971927-7	2019	Evodiamine also enhanced NLRP3-mediated production of IL-1beta and neutrophil recruitment in vivo.	evodiamine	0-10	interleukin 1 beta	Mus musculus	54-62
30971927-8	2019	Moreover, evodiamine administration evidently improved survival of mice with lethal bacterial infection, accompanied by increased production of IL-1beta and interferon-gamma, decreased bacterial load, and dampened liver inflammation.	evodiamine	10-20	interleukin 1 beta	Mus musculus	144-152
30971927-9	2019	Resveratrol treatment reversed evodiamine-induced increases of IL-1beta and interferon-gamma, and decreased bacterial clearance in mice.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	63-71
30971927-9	2019	Resveratrol treatment reversed evodiamine-induced increases of IL-1beta and interferon-gamma, and decreased bacterial clearance in mice.	evodiamine	31-41	interleukin 1 beta	Mus musculus	63-71
30481470-9	2019	In mouse primary cortical astrocytes, ARN14494 prevents the synthesis of proinflammatory cytokines TNFalpha and IL1beta, growth factor TGFbeta1, and oxidative stress-related enzymes iNOS and COX2.	SCHEMBL4438978	38-46	interleukin 1 beta	Mus musculus	112-119
30874544-11	2019	Additionally, JSH-23, a specific inhibitor of NF-kappaB nuclear translocation, rescued Ang II-driven IL-1beta production in ATG5 siRNA-treated cells and decreased the proportion of cells in G2/M phase.	4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine	14-20	interleukin 1 beta	Mus musculus	101-109
30967775-8	2019	The repeated treatment of SCI-mice with MR309 resulted in significant pain behavior attenuation beyond the end of the administration period, accompanied by reduced expression of central sensitization-related mechanistic correlates, including extracellular mediators (TNF-alpha and IL-1beta), membrane receptors/channels (NR2B-NMDA) and intracellular signaling cascades (ERK/pERK).	4-(2-((5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl)oxy)ethyl)morpholine	40-45	interleukin 1 beta	Mus musculus	281-289
30871261-6	2019	Mouse experiments showed that KTP strongly increased the serum levels of total superoxide dismutase (T-SOD) and catalase (CAT) and reduced those of malondialdehyde, interleukin 6 (IL-6), IL-1beta, and tumor necrosis factor alpha (TNF-alpha) in mice with UVB-induced skin damage.	KTP compound	30-33	interleukin 1 beta	Mus musculus	187-195
30836660-10	2019	Additionally, Sal also reduces the levels of serum biochemical markers (serum creatinine, Scr; blood urea nitrogen, BUN; and uric acid, UA) and decreases the release of inflammatory cytokines (IL-1beta, IL-6, TNF-alpha).	rhodioloside	14-17	interleukin 1 beta	Mus musculus	193-201
30586550-6	2019	Interestingly, daily intraperitoneal administration of galantamine, an inhibitor of acetylcholinesterase, reversed cognitive dysfunction in surgery mice and attenuated accumulation of microglia and protein levels of IL-1beta, IL-6 and TNF-alpha in the hippocampus.	Galantamine	55-66	interleukin 1 beta	Mus musculus	216-224
30628485-6	2019	When macrophages were stimulated with LPS followed by ATP to activate the inflammasome, we found a significant increase in secreted IL-1beta from WT cells compared with ASK1-deficient cells.	Adenosine Triphosphate	54-57	interleukin 1 beta	Mus musculus	132-140
30628485-8	2019	Subsequent ATP treatment stimulated an increase in cleaved caspase-1 and IL-1beta in WT BMDMs compared with ASK1-/- BMDMs.	Adenosine Triphosphate	11-14	interleukin 1 beta	Mus musculus	73-81
30628485-9	2019	Similarly, treatment of MH-S cells with LPS + ATP caused an increase in both cleaved caspase-1 and IL-1beta that was diminished by the ASK-1 inhibitor NQDI1.	Adenosine Triphosphate	46-49	interleukin 1 beta	Mus musculus	99-107
30597306-5	2019	Moreover, AGD significantly inhibited LPS/GalN-induced inflammatory responses in mice with ALI by reducing not only the secretion of tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 but also the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).	Galactosamine	42-46	interleukin 1 beta	Mus musculus	169-191
30097802-7	2019	We found that vanillin significantly decreased the production of nitric oxide and pro-inflammatory cytokines, including interleukin (IL)-1beta, tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6).	vanillin	14-22	interleukin 1 beta	Mus musculus	120-142
30097802-8	2019	Vanillin also reduced the protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as the mRNA expression levels of IL-1beta, TNF-alpha, and IL-6.	vanillin	0-8	interleukin 1 beta	Mus musculus	154-162
30430364-8	2019	Carnosol reduced the level of Immunoglobulin-E and IL-1beta in blood serum of UVB-induced mice.	carnosol	0-8	interleukin 1 beta	Mus musculus	51-59
30600019-6	2019	Orally administered BBG1 and BBG2 significantly decreased the pro-inflammatory mediators of IL-6, iNOS and IL-1beta at protein and/or mRNA levels, as well as colonic mucosal damage and macrophages infiltration in DSS-induced colitis mice.	bbg1	20-24	interleukin 1 beta	Mus musculus	107-115
30841450-6	2019	In BV2 microglia cells, ICE markedly inhibited production of nitric oxide and proinflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 without causing cytotoxicity.	Water	24-27	interleukin 1 beta	Mus musculus	141-158
30600019-6	2019	Orally administered BBG1 and BBG2 significantly decreased the pro-inflammatory mediators of IL-6, iNOS and IL-1beta at protein and/or mRNA levels, as well as colonic mucosal damage and macrophages infiltration in DSS-induced colitis mice.	bbg2	29-33	interleukin 1 beta	Mus musculus	107-115
30915731-7	2019	After intrathecal injection of miR-92b-5p inhibitor, the mRNA expression of miR-92b-5p, IL-18BP, and IL-18 and the expression of iNOS, TNF-alpha, and IL-1 beta in the injured area of the spinal cord of mice were measured.	mir-92b-5p	31-41	interleukin 1 beta	Mus musculus	150-159
30737255-8	2019	Importantly, alamandine decreased vascular expression of proinflammatory genes as CCL2, tumour necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and was able to increase expression of MRC1 and FIZZ1, pro-resolution markers, after TAC surgery.	alamandine	13-23	interleukin 1 beta	Mus musculus	133-150
30737255-8	2019	Importantly, alamandine decreased vascular expression of proinflammatory genes as CCL2, tumour necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and was able to increase expression of MRC1 and FIZZ1, pro-resolution markers, after TAC surgery.	alamandine	13-23	interleukin 1 beta	Mus musculus	152-160
30558807-7	2019	Additionally, exposure to 8:2 FTOH under unstimulated and LPS-stimulated conditions downregulated the mRNA expression of pro-inflammatory genes, including Il1b, Il6, Cxcl1, and Tnfa, and secreted levels of IL-6 and TNF-alpha.	Fluorocarbons	30-34	interleukin 1 beta	Mus musculus	155-159
30915731-13	2019	Moreover, the protein expression of iNOS, TNF-alpha, and IL-1 beta in miR-92b-5p inhibitor-treated mice was significantly lower than that in the SCI group.	mir-92b-5p	70-80	interleukin 1 beta	Mus musculus	57-66
30886580-4	2019	Macrophages sense TsV via innate immune receptors, including TLR2, TLR4, and CD14 that promote inflammation and mortality via PGE2/cAMP/PKA/NF-kappaB/IL-1beta axis.	(2r,6s,12z,13as,14ar,16as)-6-[(Tert-Butoxycarbonyl)amino]-14a-[(Cyclopropylsulfonyl)carbamoyl]-5,16-Dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-Hexadecahydrocyclopropa[e]pyrrolo[1,2-A][1,4]diazacyclopentadecin-2-Yl 4-Fluoro-2h-Isoindole-2-Carboxylate	18-21	interleukin 1 beta	Mus musculus	150-158
30886580-4	2019	Macrophages sense TsV via innate immune receptors, including TLR2, TLR4, and CD14 that promote inflammation and mortality via PGE2/cAMP/PKA/NF-kappaB/IL-1beta axis.	Dinoprostone	126-130	interleukin 1 beta	Mus musculus	150-158
30886580-4	2019	Macrophages sense TsV via innate immune receptors, including TLR2, TLR4, and CD14 that promote inflammation and mortality via PGE2/cAMP/PKA/NF-kappaB/IL-1beta axis.	Cyclic AMP	131-135	interleukin 1 beta	Mus musculus	150-158
30628636-6	2019	Regarding the expression of inflammatory cytokines, the levels of interleukin (IL)-6, IL-1beta and tumor necrosis factor-alpha were significantly increased, and the expression of the tight junction protein occludin was significantly decreased in the DSS/HFD-treated mice.	Dextran Sulfate	250-253	interleukin 1 beta	Mus musculus	86-126
30179264-6	2019	We found that prevention and treatment with CVC reversed alcohol-related increases in liver mRNA and protein expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and CCL2.	Alcohols	57-64	interleukin 1 beta	Mus musculus	158-180
30660077-9	2019	Butyrate significantly inhibited expressions of IL-1beta, IL-6 and IL-17A, but promoted the expression of IL-10.	Butyrates	0-8	interleukin 1 beta	Mus musculus	48-56
30415059-8	2019	RESULTS: At nontoxic concentrations, Mc-ME downregulated the release of nitric oxide (NO), the mRNA expression of inducible nitric oxide synthase (iNOS), and the mRNA expression of interleukin (IL)-1beta from LPS-activated RAW264.7 cells.	mc-me	37-42	interleukin 1 beta	Mus musculus	181-203
30563941-4	2019	Pretreatment of altenusin or GW4869 prior to lipopolysaccharide (LPS) stimulation for 4 or 24 hours, significantly downregulated gene expression of the pro-inflammatory mediators TNF-alpha, IL-1beta, IL-6, iNOS, and CCL2 in microglia and reduced the release of nitric oxide and TNF-alpha These nSMase inhibitors also attenuated the release of microparticles and phosphorylation of p38 MAPK and ERK1/2.	altenusin	16-25	interleukin 1 beta	Mus musculus	190-198
30563941-4	2019	Pretreatment of altenusin or GW4869 prior to lipopolysaccharide (LPS) stimulation for 4 or 24 hours, significantly downregulated gene expression of the pro-inflammatory mediators TNF-alpha, IL-1beta, IL-6, iNOS, and CCL2 in microglia and reduced the release of nitric oxide and TNF-alpha These nSMase inhibitors also attenuated the release of microparticles and phosphorylation of p38 MAPK and ERK1/2.	GW 4869	29-35	interleukin 1 beta	Mus musculus	190-198
30732883-10	2019	Moreover, it inhibited the Cu(II)-evoked production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and IL-1beta and expression of inducible nitric oxide synthase in the hippocampus.	cu(ii)	27-33	interleukin 1 beta	Mus musculus	156-164
30644168-6	2019	Attenuation of OA in mice treated with simvastatin-conjugated gelatin hydrogel was associated with decreased expression of cartilage-degrading enzymes and interleukin (IL)-1beta and increased expression of type II collagen and an autophagic marker, LC3, in the articular cartilage.	Simvastatin	39-50	interleukin 1 beta	Mus musculus	155-177
30644168-8	2019	Treatment with simvastatin down-regulated Mmp-13 and Il-1beta and up-regulated Col2a1 and autophagic activity.	Simvastatin	15-26	interleukin 1 beta	Mus musculus	53-61
30644041-7	2019	Expression of pro-inflammatory cytokine genes, TNF-alpha, Interleukin-12 (IL-12) and Interleukin-1beta (IL-1beta) were found to be upregulated in MPTP-intoxicated mice, whereas TCAE treatment restored their levels.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	146-150	interleukin 1 beta	Mus musculus	85-102
30685119-6	2019	Further, the anti-inflammatory effect of menadione was associated with a reduction of pancreatic and pulmonary proinflammatory cytokine interleukin 1beta (IL-1beta) and hydrogen sulfide (H2S).	Vitamin K 3	41-50	interleukin 1 beta	Mus musculus	136-153
30685119-6	2019	Further, the anti-inflammatory effect of menadione was associated with a reduction of pancreatic and pulmonary proinflammatory cytokine interleukin 1beta (IL-1beta) and hydrogen sulfide (H2S).	Vitamin K 3	41-50	interleukin 1 beta	Mus musculus	155-163
30668445-13	2019	Eucalyptol also reduced all inflammatory (MPO, TNF-alpha, IL-1beta, IL-6, KC, and TGF-beta1) and redox marker levels (MDA) when compared to the CS group (at least p &lt; 0.05).	Eucalyptol	0-10	interleukin 1 beta	Mus musculus	58-66
30637814-2	2019	Results showed that the combined treatment of quercetin with catechin synergistically attenuated LPS-stimulated increase of some proinflammatory molecules, including nitric oxide, tumor necrosis factor alpha, interleukin-1beta, nitric oxide synthase, and cyclooxygenase-2.	Quercetin	46-55	interleukin 1 beta	Mus musculus	209-226
30637814-2	2019	Results showed that the combined treatment of quercetin with catechin synergistically attenuated LPS-stimulated increase of some proinflammatory molecules, including nitric oxide, tumor necrosis factor alpha, interleukin-1beta, nitric oxide synthase, and cyclooxygenase-2.	Catechin	61-69	interleukin 1 beta	Mus musculus	209-226
30873027-5	2019	In addition, melatonin attenuated inflammation by reducing pro-inflammatory cytokines (IL-1beta and TNF-alpha) and increasing anti-inflammatory cytokines (IL-4 and IL-10).	Melatonin	13-22	interleukin 1 beta	Mus musculus	87-95
30873011-4	2019	Growing evidence has shown that mitochondria-derived reactive oxygen species (mtROS) are closely linked to IL-1beta expression through a redox sensor known as the nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome.	Reactive Oxygen Species	53-76	interleukin 1 beta	Mus musculus	107-115
30937316-15	2019	Budesonide significantly suppressed NLRP3 and pro-caspase-1 expression in the lung and reduced IL-1beta content in the BALF, indicating that budesonide inhibited the activation of the NLRP3 inflammasome.	Budesonide	0-10	interleukin 1 beta	Mus musculus	95-103
30937316-15	2019	Budesonide significantly suppressed NLRP3 and pro-caspase-1 expression in the lung and reduced IL-1beta content in the BALF, indicating that budesonide inhibited the activation of the NLRP3 inflammasome.	Budesonide	141-151	interleukin 1 beta	Mus musculus	95-103
30931327-9	2019	The expression of TNF-alpha, IL-1beta, IL-6, MMP-1, MMP-3, MMP-13, ADAMTS4, and ADAMTS5 was significantly reduced both in vitro and in vivo by the presence of SA.	sinapinic acid	159-161	interleukin 1 beta	Mus musculus	29-37
30833971-9	2019	Inflammatory cytokines, such as TNF-alpha, IL-6 and IL-1beta, were significantly inhibited in honokiol-treated septic mice compared with the CLP group.	honokiol	94-102	interleukin 1 beta	Mus musculus	52-60
30873011-4	2019	Growing evidence has shown that mitochondria-derived reactive oxygen species (mtROS) are closely linked to IL-1beta expression through a redox sensor known as the nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome.	mtros	78-83	interleukin 1 beta	Mus musculus	107-115
30918468-5	2019	Our results showed that Ang-(1-7) and alamandine, through Mas and MrgD receptors, respectively, do not affect M0 macrophages but reduce the proinflammatory TNF-alpha, CCL2, and IL-1beta transcript expression levels in LPS+IFN-gamma-stimulated macrophages.	alamandine	38-48	interleukin 1 beta	Mus musculus	177-185
30783194-9	2019	Th-17 associated pro-inflammatory gene [interleukin 1 beta (IL-1beta), IL-6, IL-17A, and tumor necrosis factor alpha (TNF-alpha)] expressions were down regulated by GTE and EGCG treatments, which showed no detectable morphological defects in liver and kidney in non-induced and EAU mice.	epigallocatechin gallate	165-168	interleukin 1 beta	Mus musculus	40-58
30787297-5	2019	Mechanistically, diclofenac enhanced cardiac reprogramming by inhibiting cyclooxygenase-2, prostaglandin E2/prostaglandin E receptor 4, cyclic AMP/protein kinase A, and interleukin 1beta signaling and by silencing inflammatory and fibroblast programs, which were activated in postnatal and adult TTFs.	Diclofenac	17-27	interleukin 1 beta	Mus musculus	169-186
30779140-10	2019	RESULTS: We found that metformin treatment can robustly ameliorate periodontal infection and tissue destruction and reduce blood glucose and serum IL-1beta levels in mice with diabetic periodontitis.	Metformin	23-32	interleukin 1 beta	Mus musculus	147-155
30783194-9	2019	Th-17 associated pro-inflammatory gene [interleukin 1 beta (IL-1beta), IL-6, IL-17A, and tumor necrosis factor alpha (TNF-alpha)] expressions were down regulated by GTE and EGCG treatments, which showed no detectable morphological defects in liver and kidney in non-induced and EAU mice.	epigallocatechin gallate	173-177	interleukin 1 beta	Mus musculus	40-58
30582907-12	2019	Moreover, acetyl PC downregulated the mRNA levels of inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-4, as well as myeloperoxidase activity, in the ear tissue of DNFB-treated mice.	acetyl pc	10-19	interleukin 1 beta	Mus musculus	116-138
30582907-12	2019	Moreover, acetyl PC downregulated the mRNA levels of inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-4, as well as myeloperoxidase activity, in the ear tissue of DNFB-treated mice.	Dinitrofluorobenzene	208-212	interleukin 1 beta	Mus musculus	116-138
30240278-6	2019	Treatment of silica-challenged mice with anti-IL-9-neutralizing antibody inhibited lung fibrosis, as assessed by lung hydroxyproline level, and suppressed the levels of major mediators, including IL-1beta, IL-6, IL-12, CCL2, CXCL1, and TNF-alpha in BALFs.	Silicon Dioxide	13-19	interleukin 1 beta	Mus musculus	196-204
30833897-10	2019	Importantly, GLA decreased production of M1 cytokines (IL-1beta and TNF-alpha) but increased production of M2 cytokines (IL-10 and TGF-beta) in the colonic macrophage with the downregulation of NF-kappaB and the upregulation of STAT6.	glabridin	13-16	interleukin 1 beta	Mus musculus	55-63
30764851-12	2019	Depletion of macrophages by injection of clodronate liposomes attenuated LPS-induced IL-1beta expression in the SFO.	Clodronic Acid	41-51	interleukin 1 beta	Mus musculus	85-93
30890898-4	2019	The results demonstrate that melatonin inhibited the mRNA expression of TNF-alpha, IL-1beta, IL-6, CXCL1, MCP-1, and RANTES and the production of these cytokines and chemokines and IgG in LPS-stimulated mouse mammary tissue in vitro.	Melatonin	29-38	interleukin 1 beta	Mus musculus	83-91
30746687-5	2019	Moreover, myricetin pretreatment induced a significant decrease in the activity of myeloperoxidase (MPO) and the production of TNF-alpha, IL-6, and IL-1beta triggered by LPS.	myricetin	10-19	interleukin 1 beta	Mus musculus	148-156
30726742-7	2019	beta2-integrin expression on macrophages is mechanistically linked to Rac1/ROS-mediated induction of noncanonical-NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome-dependent IL-1beta production, which promotes ILC3-derived IL-22.	ros	75-78	interleukin 1 beta	Mus musculus	230-238
30699879-8	2019	Moreover, simvastatin markedly prevented and ameliorated LPS and CMS-induced neuroinflammation, as shown by the suppressed activation of microglia in hippocampus and decreased hippocampal pro-inflammatory cytokines expressions including IL-1beta, TNF-alpha, IL-6, which might be mediated via the inhibition of NF-kappaB pathway, as shown by the decreased nuclear NF-kappaB p65 expression.	Simvastatin	10-21	interleukin 1 beta	Mus musculus	237-245
30559153-9	2019	Microglial elimination also attenuated RSD-induced IL-1beta, CCR2, and TLR4 mRNA expression in the lumbar spinal cord.	RSD	39-42	interleukin 1 beta	Mus musculus	51-59
30759768-7	2019	Choline supplementation decreased (p &lt; 0.05) expression of pro-angiogenic genes Eng (E10.5, E12.5, and E15.5), and Vegf (E12.5, E15.5); and pro-inflammatory genes Il1b (at E15.5 and 18.5), Tnfalpha (at E12.5) and Nfkappab (at E15.5) in a fetal sex-dependent manner.	Choline	0-7	interleukin 1 beta	Mus musculus	166-170
30483725-7	2019	Isorhamnetin also downregulated LPS-induced production and expression of pro-inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-1beta.	3-methylquercetin	0-12	interleukin 1 beta	Mus musculus	141-158
30253123-7	2019	DOP also inhibited the increased hippocampal microglial activation in SAMP8 mice with downregulation of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), while interleukin-10 (IL-10), neprilysin (NEP) and insulin-degrading enzyme (IDE) were upregulated.	Diethylhexyl Phthalate	0-3	interleukin 1 beta	Mus musculus	104-121
30253123-7	2019	DOP also inhibited the increased hippocampal microglial activation in SAMP8 mice with downregulation of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), while interleukin-10 (IL-10), neprilysin (NEP) and insulin-degrading enzyme (IDE) were upregulated.	Diethylhexyl Phthalate	0-3	interleukin 1 beta	Mus musculus	123-131
30704333-8	2019	In addition, systemic sclareol treatments reduced local pro-inflammatory cytokine concentrations, including IL-6, IL-1b, TNF-a, IL-4, IFN-g, and IL-17A, on AD-like lesions.	sclareol	22-30	interleukin 1 beta	Mus musculus	114-119
30557824-0	2019	Rapamycin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting IL-1beta and IL-18 production.	Sirolimus	0-9	interleukin 1 beta	Mus musculus	81-89
30557824-2	2019	However, it is not clear whether the mTOR specific inhibitor rapamycin can attenuate lipopolysaccharide (LPS)-induced ALI by modulating IL-1beta and IL-18 production.	Sirolimus	61-70	interleukin 1 beta	Mus musculus	136-144
30557824-3	2019	In this study, we found that rapamycin ameliorated LPS-induced ALI by inhibiting NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated IL-1beta and IL-18 secretion.	Sirolimus	29-38	interleukin 1 beta	Mus musculus	162-170
30554117-5	2019	The production of TNF-alpha, IL-1beta and IL-6 was also significantly inhibited by EVO.	evodiamine	83-86	interleukin 1 beta	Mus musculus	29-37
30446103-5	2019	The CIF2 polysaccharide, as the most immunostimulating polysaccharide, remarkably induced the release of nitric oxide and inflammatory cytokines including TNF-alpha, IL-1beta, IL-6 and IL-10 from RAW264.7 murine macrophage cells through NF-kappaB and PAMKs transduction signaling pathways via cell surface TLR4.	cif2 polysaccharide	4-23	interleukin 1 beta	Mus musculus	166-174
30446103-5	2019	The CIF2 polysaccharide, as the most immunostimulating polysaccharide, remarkably induced the release of nitric oxide and inflammatory cytokines including TNF-alpha, IL-1beta, IL-6 and IL-10 from RAW264.7 murine macrophage cells through NF-kappaB and PAMKs transduction signaling pathways via cell surface TLR4.	Polysaccharides	9-23	interleukin 1 beta	Mus musculus	166-174
30536526-7	2019	In addition, exposure to 8:2 FTOH reduced the concentration of IL-1beta in serum, and mRNA levels of IL-1beta, IL-6, and TNF-alpha in both the thymus and spleen.	ftoh	29-33	interleukin 1 beta	Mus musculus	63-71
30536526-7	2019	In addition, exposure to 8:2 FTOH reduced the concentration of IL-1beta in serum, and mRNA levels of IL-1beta, IL-6, and TNF-alpha in both the thymus and spleen.	ftoh	29-33	interleukin 1 beta	Mus musculus	101-109
30840301-13	2019	Mice in the NaB treatment group showed significantly lower levels of IL-1beta, TNF-alpha and IL-8.	nab	12-15	interleukin 1 beta	Mus musculus	69-77
30317449-0	2019	Interleukin-1beta in synergism gabapentin with tramadol in murine model of diabetic neuropathy.	Gabapentin	31-41	interleukin 1 beta	Mus musculus	0-17
30317449-0	2019	Interleukin-1beta in synergism gabapentin with tramadol in murine model of diabetic neuropathy.	Tramadol	47-55	interleukin 1 beta	Mus musculus	0-17
30317449-2	2019	The aim of this study was to evaluate the role of the biomarker interleukin-1beta (IL-1ss) in the pharmacological interaction of gabapentin with tramadol in a model of diabetic neuropathic pain.	Gabapentin	129-139	interleukin 1 beta	Mus musculus	64-81
30317449-2	2019	The aim of this study was to evaluate the role of the biomarker interleukin-1beta (IL-1ss) in the pharmacological interaction of gabapentin with tramadol in a model of diabetic neuropathic pain.	Tramadol	145-153	interleukin 1 beta	Mus musculus	64-81
30317449-9	2019	The combination of gabapentin with tramadol reversed the increased concentration of IL-1beta induced by STZ in diabetic neuropathic mice.	Gabapentin	19-29	interleukin 1 beta	Mus musculus	84-92
30317449-9	2019	The combination of gabapentin with tramadol reversed the increased concentration of IL-1beta induced by STZ in diabetic neuropathic mice.	Tramadol	35-43	interleukin 1 beta	Mus musculus	84-92
30317449-9	2019	The combination of gabapentin with tramadol reversed the increased concentration of IL-1beta induced by STZ in diabetic neuropathic mice.	Streptozocin	104-107	interleukin 1 beta	Mus musculus	84-92
30067872-6	2019	Although treatment with ivabradine did not affect blood glucose levels, it attenuated tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 messenger RNA (mRNA) expression, inhibited c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) activation, reduced histological abnormalities, myocardial apoptosis and collagen deposition, and improved cardiac function in the diabetic mice.	Ivabradine	24-34	interleukin 1 beta	Mus musculus	115-132
30445417-9	2019	Moreover, sesamin treatment significantly prevented CUMS-induced neuroinflammation by inhibiting over-activation of microglia and expressions of inflammatory mediators including iNOS, COX-2, TNF-alpha and IL-1beta in stressed mice hippocampus and cortex.	sesamin	10-17	interleukin 1 beta	Mus musculus	205-213
30569161-9	2019	Furthermore, the mRNA expression levels of IL-1beta and MCP-1 were significantly elevated following addition of the S1PR1 inhibitor W146, but not by the scavenger receptor class B type I inhibitor, block lipid transport-1 (BLT-1), in apoMTg cells prior to TNF-alpha treatment.	W146	132-136	interleukin 1 beta	Mus musculus	43-51
30414103-5	2019	Cd accumulation was recorded in the cortical homogenates, accompanied by elevated levels of lipid peroxidation, nitric oxide, tumor necrosis factor-alpha, interleukin-1beta, and the pro-apoptotic mRNA Bax and caspase-3.	Cadmium	0-2	interleukin 1 beta	Mus musculus	155-172
30610999-0	2019	Electroacupuncture at ST-36 ameliorates DSS-induced acute colitis via regulating macrophage polarization induced by suppressing NLRP3/IL-1beta and promoting Nrf2/HO-1.	Dextran Sulfate	40-43	interleukin 1 beta	Mus musculus	134-142
30610999-12	2019	(4) NLRP3/IL-1beta protein and mRNA levels in isolated macrophages decreased with HEA and LEA compared with the DSS treatment group; (5) HEA increased Nrf2/HO-1 levels compared with levels in DSS mice.	Dextran Sulfate	112-115	interleukin 1 beta	Mus musculus	10-18
29117731-7	2019	Amaroswerin thus inhibits the expression of iNOS, TNF-alpha, IL-6 and IL-1beta by downregulating transcription in LPS-induced RAW264.7 macrophage cells, indicating that amaroswerin may be a valuable therapeutic agent for the treatment of inflammatory diseases.	Amaroswerin	0-11	interleukin 1 beta	Mus musculus	70-78
29117731-6	2019	Amaroswerin also dose-dependently suppressed production of TNF-alpha, IL-6 and IL-1beta and reduced expression of mRNA for these LPS-stimulated pro-inflammatory mediators.	Amaroswerin	0-11	interleukin 1 beta	Mus musculus	79-87
29117731-7	2019	Amaroswerin thus inhibits the expression of iNOS, TNF-alpha, IL-6 and IL-1beta by downregulating transcription in LPS-induced RAW264.7 macrophage cells, indicating that amaroswerin may be a valuable therapeutic agent for the treatment of inflammatory diseases.	Amaroswerin	169-180	interleukin 1 beta	Mus musculus	70-78
30336174-5	2019	Additionally, butein treatment enhanced SIRT1 signaling thus decreasing the Ac-NF-kappaB, Ac-FOXO1 and Ac-p53 levels, thus attenuating the brain injury of mice after CLP surgery by decreasing cerebral edema, maintaining the blood-brain barrier integrity, inhibiting neuronal apoptosis, and decreasing pro-inflammatory cytokines production (IL-6, TNF-alpha and IL-1beta) and oxidative stress (downregulation of MDA, and upregulation of SOD and CAT) in both serum and cerebral cortex tissues.	butein	14-20	interleukin 1 beta	Mus musculus	360-368
30666488-6	2019	AU significantly attenuated the activation of astrocytes and microglia and reduced the levels of interleukine-1 beta (IL-1beta), high mobility group box 1 (HMGB1), tumor necrosis factor-alpha (TNF-alpha).	aucubin	0-2	interleukin 1 beta	Mus musculus	118-126
30782259-5	2019	The result of W/D ratio showed that paeonol could also prevent pulmonary edema, as well as inhibit significantly the levels of TNF-alpha, IL-1beta and IL-6 in serum and proteins expression and mRNA.	paeonol	36-43	interleukin 1 beta	Mus musculus	138-146
30989921-5	2019	The swelling degree of ankle joint significantly relief; expression of IL-1beta, IL-6 and TNF-alpha in joint synovium significantly decrease; mRNA and protein expression of NLRP3, ASC and caspase-1 were significantly decrease in PCE treatment group compared with model group.	pce	229-232	interleukin 1 beta	Mus musculus	71-79
30657794-8	2019	In fact, the elevated levels of retinal NLRP3 inflammasome activation markers (NLRP3, ASC, caspase-1) and of the relative proinflammatory cytokines (IL-1beta, IL-18) were significantly reduced by 50 mg/kg and 100 mg/kg beta-hydroxybutyrate treatment.	3-Hydroxybutyric Acid	219-239	interleukin 1 beta	Mus musculus	149-157
30515710-15	2019	Finally, allicin supplementation inhibited the Nucleotide-binding oligomerization domain containing 3 (NLRP3) inflammasome hyperactivity, and the expressions of inflammasome components, such as ACS, caspase-1, and IL-1beta in the hippocampus of CSDS mice.	allicin	9-16	interleukin 1 beta	Mus musculus	214-222
30761140-3	2019	Here we showed that paclitaxel pre-treatment greatly enhanced ATP- or nigericin-induced NLRP3 inflammasome activation as indicated by increased release of cleaved caspase-1 and mature IL-1beta, enhanced formation of ASC speck, and increased gasdermin D cleavage and pyroptosis.	Paclitaxel	20-30	interleukin 1 beta	Mus musculus	184-192
30761140-3	2019	Here we showed that paclitaxel pre-treatment greatly enhanced ATP- or nigericin-induced NLRP3 inflammasome activation as indicated by increased release of cleaved caspase-1 and mature IL-1beta, enhanced formation of ASC speck, and increased gasdermin D cleavage and pyroptosis.	Adenosine Triphosphate	62-65	interleukin 1 beta	Mus musculus	184-192
30761140-3	2019	Here we showed that paclitaxel pre-treatment greatly enhanced ATP- or nigericin-induced NLRP3 inflammasome activation as indicated by increased release of cleaved caspase-1 and mature IL-1beta, enhanced formation of ASC speck, and increased gasdermin D cleavage and pyroptosis.	Nigericin	70-79	interleukin 1 beta	Mus musculus	184-192
30761140-8	2019	Consistent with the in vitro results, intraperitoneal administration of paclitaxel significantly increased serum IL-1beta levels, reduced bacterial burden, dampened infiltration of inflammatory cells in the liver, and improved animal survival in a mouse model of bacterial infection.	Paclitaxel	72-82	interleukin 1 beta	Mus musculus	113-121
30584213-3	2019	In this study, we investigated the inhibitory property of metformin on mitochondrial damage by focusing on the interleukin-1 beta (IL-1beta)-stimulated osteoarthritis model by using primary murine chondrocytes.	Metformin	58-67	interleukin 1 beta	Mus musculus	111-129
30584213-3	2019	In this study, we investigated the inhibitory property of metformin on mitochondrial damage by focusing on the interleukin-1 beta (IL-1beta)-stimulated osteoarthritis model by using primary murine chondrocytes.	Metformin	58-67	interleukin 1 beta	Mus musculus	131-139
30658416-10	2019	Besides, BA treatment considerably inhibited inflammatory cytokinesl (IL-1beta, IL-6, TNF-alpha) levels in serum, hippocampus homogenate and cell culture medium.	baicalin	9-11	interleukin 1 beta	Mus musculus	70-78
30468814-6	2019	CPZ-induced activation and proliferation of microglia were not inhibited by GEN. Upregulation of gene expression of the pro-inflammatory cytokine, interleukin-1beta, in sorted microglia by CPZ was not inhibited by GEN either.	Cuprizone	0-3	interleukin 1 beta	Mus musculus	147-164
30642005-5	2019	Our data also revealed upregulated CB1R, interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, c-Jun, and type 4 collagen in the glomeruli of streptozotocin (STZ)-induced diabetic mice, whereas the expression of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) was decreased.	Streptozocin	151-165	interleukin 1 beta	Mus musculus	41-58
30650605-7	2019	Furthermore, ascorbic acid ameliorated D-gal-induced downregulation of superoxide dismutase 1 and 2, sirtuin1, caveolin-1, and brain-derived neurotrophic factor and upregulation of interleukin 1 beta and tumor necrosis factor alpha in the hippocampus.	Galactose	39-44	interleukin 1 beta	Mus musculus	181-231
30650605-7	2019	Furthermore, ascorbic acid ameliorated D-gal-induced downregulation of superoxide dismutase 1 and 2, sirtuin1, caveolin-1, and brain-derived neurotrophic factor and upregulation of interleukin 1 beta and tumor necrosis factor alpha in the hippocampus.	Ascorbic Acid	13-26	interleukin 1 beta	Mus musculus	181-231
30622196-4	2019	Exposing activated mouse microglial cells to Mn2+ substantially augmented NLRP3 abundance, caspase-1 cleavage, and maturation of the inflammatory cytokine interleukin-1beta (IL-1beta).	Manganese(2+)	45-49	interleukin 1 beta	Mus musculus	155-172
30626741-9	2019	In-vivo administration of viniferin reduced production of inflammatory mediators TNF-alpha, MIP-2, IL-6, IL-1beta, and HMGB1, and diminished neutrophil influx and severity of endotoxin-mediated ALI; this protective effect of vinferin was abolished in SIRT3-/- mice.	Viniferin	26-35	interleukin 1 beta	Mus musculus	105-113
30662948-5	2019	Exaggerated NLRP3 and IL-1beta expression in Vsig4-/- mice is accountable for deleterious disease severity in experimental autoimmune encephalomyelitis (EAE) and resistance to dextran sulfate sodium (DSS)-induced colitis.	Dextran Sulfate	176-198	interleukin 1 beta	Mus musculus	22-30
30687331-7	2018	Dasatinib treatment inhibited the production of proinflammatory cytokines including IL-1beta, TNF-alpha, and IL-6, and promoted the production of the anti-inflammatory cytokine IL-10.	Dasatinib	0-9	interleukin 1 beta	Mus musculus	84-92
30670973-6	2018	Mechanistically, midazolam suppressed tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) produced by LPS stimulated liver macrophages in vivo and bone marrow monocytes in vitro, and reduced the expression of major histocompatibility complex class II (MHC II), cluster of differentiation 40 and 86 (CD40 and CD86) on the cell surface.	Midazolam	17-26	interleukin 1 beta	Mus musculus	82-99
30670973-6	2018	Mechanistically, midazolam suppressed tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) produced by LPS stimulated liver macrophages in vivo and bone marrow monocytes in vitro, and reduced the expression of major histocompatibility complex class II (MHC II), cluster of differentiation 40 and 86 (CD40 and CD86) on the cell surface.	Midazolam	17-26	interleukin 1 beta	Mus musculus	101-109
30622196-4	2019	Exposing activated mouse microglial cells to Mn2+ substantially augmented NLRP3 abundance, caspase-1 cleavage, and maturation of the inflammatory cytokine interleukin-1beta (IL-1beta).	Manganese(2+)	45-49	interleukin 1 beta	Mus musculus	174-182
30455347-7	2019	RORgamma inverse agonists suppressed lipopolysaccharide (LPS)/ATP-stimulated IL-1beta secretion and expression of Il1b and Nlrp3 in BMDMs.	Adenosine Triphosphate	62-65	interleukin 1 beta	Mus musculus	77-85
30455347-7	2019	RORgamma inverse agonists suppressed lipopolysaccharide (LPS)/ATP-stimulated IL-1beta secretion and expression of Il1b and Nlrp3 in BMDMs.	Adenosine Triphosphate	62-65	interleukin 1 beta	Mus musculus	114-118
29797206-8	2019	Cr(III) reduced the content of pro-inflammatory cytokines (IL-1beta and TNF-alpha, IL-12) and restored the level of anti-inflammatory cytokine (IL-10) to the control values.	tris(1,10-phenanthroline)chromium(III) chloride	0-7	interleukin 1 beta	Mus musculus	59-67
31645121-10	2019	In dextran sulfated sodium (DSS)-induced colitis mice model, RSBE restored body weight, colon length, and the levels of pro-inflammatory cytokines, such as TNF-alpha, IL-6, interleukin-1beta (IL-1beta), and interferon-gamma (IFN-gamma).	dextran sulfated sodium	3-26	interleukin 1 beta	Mus musculus	173-190
31645121-10	2019	In dextran sulfated sodium (DSS)-induced colitis mice model, RSBE restored body weight, colon length, and the levels of pro-inflammatory cytokines, such as TNF-alpha, IL-6, interleukin-1beta (IL-1beta), and interferon-gamma (IFN-gamma).	dss	28-31	interleukin 1 beta	Mus musculus	173-190
30460722-5	2019	The results showed that beta-carotene significantly suppressed (p &lt; 0.05) LPS-induced release of IL-1beta, IL-6, and TNF-alpha and their mRNA expression.	beta Carotene	24-37	interleukin 1 beta	Mus musculus	100-108
30084961-5	2019	The mRNA expression levels of endometrial receptivity markers leukemia inhibitory factor, interleukin-1beta, and integrin beta-3 were increased in mice treated with either BMDCs, CXCL12, or both.	bmdcs	172-177	interleukin 1 beta	Mus musculus	90-107
30551352-7	2019	Increased secretion of pro-inflammatory cytokines TNF-alpha, IL-1beta and IL-6, caused by LPSs was reversed by TFE; on the contrary, the anti-inflammatory cytokine IL-10 was upregulated.	lpss	90-94	interleukin 1 beta	Mus musculus	61-69
30399591-4	2019	GA also decreased the expressions of pro-inflammatory cytokines, including TNF-alpha, IL-6 and IL-1beta.	gambogic acid	0-2	interleukin 1 beta	Mus musculus	95-103
30396067-11	2019	Farrerol also inhibited the induction effect of Abeta on IL-6, IL-1beta, and TNF-alpha.	farrerol	0-8	interleukin 1 beta	Mus musculus	63-71
30551352-7	2019	Increased secretion of pro-inflammatory cytokines TNF-alpha, IL-1beta and IL-6, caused by LPSs was reversed by TFE; on the contrary, the anti-inflammatory cytokine IL-10 was upregulated.	Trifluoroethanol	111-114	interleukin 1 beta	Mus musculus	61-69
30713248-9	2019	Here, we found in mice that (i) intravenous zoledronate exhibited weaker inflammatory effects than intraperitoneal zoledronate, (ii) in mice given intravenous zoledronate, LPS-induced production of IL-1alpha and IL-1beta was augmented in various tissues, including bone, resulting in them increasing in serum, and (iii) clodronate (given together with zoledronate) prevented such augmentation and enhanced, slightly but significantly, zoledronate"s anti-bone-resorptive effect.	Zoledronic Acid	44-55	interleukin 1 beta	Mus musculus	212-220
31241712-8	2019	In addition, EGCG significantly decreased the expression of pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 in the lung, serum, and bronchoalveolar lavage fluid, and alleviated the expression of TLR-4, MyD88, TRIF, and p-p65 in the lung tissue.	epigallocatechin gallate	13-17	interleukin 1 beta	Mus musculus	122-144
31155589-0	2019	Effects of Zoledronate on Local and Systemic Production of IL-1beta, IL-18, and TNF-alpha in Mice and Augmentation by Lipopolysaccharide.	Zoledronic Acid	11-22	interleukin 1 beta	Mus musculus	59-67
31155589-6	2019	In systemic experiments using intraperitoneal injection of zoledronate and/or LPS, (i) zoledronate by itself increased none of the above cytokines in serum, and (ii) in mice pretreated (3 d before) with zoledronate, the LPS-induced increases in serum IL-1beta and IL-18 were greatly augmented with a delayed slight TNF-alpha augmentation.	Zoledronic Acid	87-98	interleukin 1 beta	Mus musculus	251-259
31155589-6	2019	In systemic experiments using intraperitoneal injection of zoledronate and/or LPS, (i) zoledronate by itself increased none of the above cytokines in serum, and (ii) in mice pretreated (3 d before) with zoledronate, the LPS-induced increases in serum IL-1beta and IL-18 were greatly augmented with a delayed slight TNF-alpha augmentation.	Zoledronic Acid	87-98	interleukin 1 beta	Mus musculus	251-259
31155589-7	2019	These results, together with previous ones, suggest that (a) pro-IL-1beta and pro-IL-18 accumulate within cells in soft-tissues exposed to N-BPs, and infection may augment not only their production, but also the release of their mature forms, (b) IL-1beta and IL-18 (possibly together with TNF-alpha) may play important roles in N-BP-induced inflammation and/or necrosis, and (c) mechanisms underlying the cytotoxic effects of BPs may differ between N-BPs and non-N-BPs.	n-bps	139-144	interleukin 1 beta	Mus musculus	65-73
31155589-7	2019	These results, together with previous ones, suggest that (a) pro-IL-1beta and pro-IL-18 accumulate within cells in soft-tissues exposed to N-BPs, and infection may augment not only their production, but also the release of their mature forms, (b) IL-1beta and IL-18 (possibly together with TNF-alpha) may play important roles in N-BP-induced inflammation and/or necrosis, and (c) mechanisms underlying the cytotoxic effects of BPs may differ between N-BPs and non-N-BPs.	n-bp	139-143	interleukin 1 beta	Mus musculus	65-73
31155589-7	2019	These results, together with previous ones, suggest that (a) pro-IL-1beta and pro-IL-18 accumulate within cells in soft-tissues exposed to N-BPs, and infection may augment not only their production, but also the release of their mature forms, (b) IL-1beta and IL-18 (possibly together with TNF-alpha) may play important roles in N-BP-induced inflammation and/or necrosis, and (c) mechanisms underlying the cytotoxic effects of BPs may differ between N-BPs and non-N-BPs.	Diphosphonates	141-144	interleukin 1 beta	Mus musculus	65-73
31685770-3	2019	GE (100 microg/mL) completely inhibited tumor necrosis factor-alpha-induced endothelin-1, monocyte chemoattractant protein-1, interleukin-1beta, and intercellular adhesion molecule-1 gene expression in cultured endothelial cells.	Germanium	0-2	interleukin 1 beta	Mus musculus	126-143
31241715-4	2019	Moreover, BA reduced the levels of inflammatory cytokines, such as interleukin 1beta, interleukin 6, and tumor necrosis factor alpha, in serum and in the hippocampus.	baicalin	10-12	interleukin 1 beta	Mus musculus	67-84
29786072-5	2019	Furthermore, NLRP3 deficiency abolishes MPTP-induced microglial recruitment, interleukin-1beta production and caspase-1 activation in the SN of mouse brain.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	40-44	interleukin 1 beta	Mus musculus	77-94
30539784-9	2019	Moreover, rifampicin significantly lowered the levels of interleukin-6, interleukin-1beta, caspase-12 activity, heme oxygenase-1(HO-1), nitric oxide (NO), and malondialdehyde (MDA) in mice treated with cuprizone.	Rifampin	10-20	interleukin 1 beta	Mus musculus	72-89
26542309-14	2019	The expressions of IL-6, TNF-alpha and IL-1beta increased, and TGF-beta levels decreased in the cirrhotic livers after GSG treatment (IL-6: F=5.457, P=0.004; TNF-alpha: F=6.023, P=0.002; IL-1beta: F=6.658, P=0.001; and TGF-beta1: F=11.239, P=0.000).	SCHEMBL948318	119-122	interleukin 1 beta	Mus musculus	39-47
26542309-14	2019	The expressions of IL-6, TNF-alpha and IL-1beta increased, and TGF-beta levels decreased in the cirrhotic livers after GSG treatment (IL-6: F=5.457, P=0.004; TNF-alpha: F=6.023, P=0.002; IL-1beta: F=6.658, P=0.001; and TGF-beta1: F=11.239, P=0.000).	SCHEMBL948318	119-122	interleukin 1 beta	Mus musculus	187-195
30315662-10	2019	In addition, sulforaphane significantly activated Nrf2 and reduced both the gene and protein expression of NFkappaB, TNF-alpha, IL-1beta and caspase-3.	sulforaphane	13-25	interleukin 1 beta	Mus musculus	128-136
31119985-5	2019	Consequently, the biologically active forms of the inflammatory cytokines IL-1beta and IL-18 are reduced significantly in response to Honokiol in mice infected with S. aureus.	honokiol	134-142	interleukin 1 beta	Mus musculus	74-82
30453147-8	2019	Treatment with NecroX-5 considerably ameliorated the progression of DSS-induced colitis and significantly inhibited the mRNA expression of pro-inflammatory cytokines, including tumor necrosis factor-alpha and IL-1beta.	NecroX-5	15-23	interleukin 1 beta	Mus musculus	209-217
30415189-4	2019	PPL decreased the mitochondrial membrane potential (MMP) and increased the outflow of calcium, accompanied by the overproduction of reactive oxygen species (ROS), which resulted in the activation of the MAPK and NF-kappaB pathways and the release of IL-1beta.	Reactive Oxygen Species	132-155	interleukin 1 beta	Mus musculus	250-258
30415189-9	2019	Further, we found that N-acetylcysteine (NAC), an ROS scavenger, could inhibit the PPL-stimulated activation of these pathways and the release of IL-1beta.	Acetylcysteine	23-39	interleukin 1 beta	Mus musculus	146-154
30415189-9	2019	Further, we found that N-acetylcysteine (NAC), an ROS scavenger, could inhibit the PPL-stimulated activation of these pathways and the release of IL-1beta.	Acetylcysteine	41-44	interleukin 1 beta	Mus musculus	146-154
30342124-7	2019	The EPSs exerted the antiproliferative effectivity; treatment of EPS induced proinflammatory cytokines TNF-alpha, IL-6, IL-12, IL-1beta and IL-17, also engaged in anti-cancer immunity.	epss	4-8	interleukin 1 beta	Mus musculus	127-135
30342124-7	2019	The EPSs exerted the antiproliferative effectivity; treatment of EPS induced proinflammatory cytokines TNF-alpha, IL-6, IL-12, IL-1beta and IL-17, also engaged in anti-cancer immunity.	exophthalmos producing substance	4-7	interleukin 1 beta	Mus musculus	127-135
30415189-9	2019	Further, we found that N-acetylcysteine (NAC), an ROS scavenger, could inhibit the PPL-stimulated activation of these pathways and the release of IL-1beta.	Reactive Oxygen Species	50-53	interleukin 1 beta	Mus musculus	146-154
31933729-5	2019	After intrathecal injection of ZD-7288 and si-HCN2, both MWT and PWL were significantly increased, while the level of pro-inflammatory factors TNF-alpha, IL-1beta and MCP-1 were decreased in L4-L5 ipsilateral spinal dorsal horn.	ICI D2788	31-38	interleukin 1 beta	Mus musculus	154-162
30806288-8	2019	Furthermore, oral administration of DA decreased the level of myeloperoxidase (MPO) and inhibited the expression of p65-NF-kappaB, p-IkappaB-alpha, and p-IKK as well as several inflammatory factors, including TNF-alpha, IL-1beta, and IL-6, in the colonic tissues.	daidzein	36-38	interleukin 1 beta	Mus musculus	220-228
31337260-7	2019	Berberine inhibited the expression of pro-inflammatory cytokines including tumor necrosis factor (TNF)-alpha, interleukin-6 (IL-6), and interleukin-1beta (IL-1beta), along with inflammatory proteins including iNOS and COX-2.	Berberine	0-9	interleukin 1 beta	Mus musculus	136-153
31337260-7	2019	Berberine inhibited the expression of pro-inflammatory cytokines including tumor necrosis factor (TNF)-alpha, interleukin-6 (IL-6), and interleukin-1beta (IL-1beta), along with inflammatory proteins including iNOS and COX-2.	Berberine	0-9	interleukin 1 beta	Mus musculus	155-163
30705514-9	2019	Astaxanthin significantly suppressed the mucosal mRNA expression of IL-1beta, IL-6, TNF-alpha, IL-36alpha and IL-36gamma.	astaxanthine	0-11	interleukin 1 beta	Mus musculus	68-76
30539754-8	2019	Furthermore, STV-Na pretreatment significantly downregulated expressions of nitric oxide synthase, interleukin-1beta, tumor necrosis factor-alpha, interleukin-6, nuclear factor kappa B (NF-kappaB), and mitogen-activated protein kinase (MAPK) signalings in N2a cells under conditions of CoCl2-induced hypoxia.	stv-na	13-19	interleukin 1 beta	Mus musculus	99-145
30120937-3	2019	Here, we show that IL-1beta is significantly elevated in psoriatic lesional skin and imiquimod-treated mouse skin.	Imiquimod	85-94	interleukin 1 beta	Mus musculus	19-27
30528467-5	2019	RESULTS: Schaftoside inhibited mRNA and protein expressions of proinflammatory cytokines (IL-1beta, TNF-alpha, and IL-6) after 4 h in OGD-stimulated BV2 microglia cells, similar to the effect of TAK242, an inhibitor of TLR4.	schaftoside	9-20	interleukin 1 beta	Mus musculus	90-98
30468833-9	2019	Moreover, CT-133 not only reversed the uncontrolled secretion of IL-1beta, IL-6, TNF-alpha and KC from CSE- and PGD2-stimulated RAW 264.7 macrophages but also augmented IL-10 production in both in vivo and in vitro studies.	ct-133	10-16	interleukin 1 beta	Mus musculus	65-73
31266025-4	2019	In cultured podocytes, we found that L-Hcy (the active Hcy form) stimulated the NLRP3 inflammasome formation, as shown by increased colocalization of NLRP3 with apoptosis-associated speck-like protein (ASC) or caspase-1, which was accompanied by increased interleukin-1beta production and caspase-1 activity, indicating NLRP3 inflammasome activation.	Homocysteine	37-42	interleukin 1 beta	Mus musculus	256-273
30690444-2	2019	Results suggested that ropivacaine causes significant inhibition of generation of nitric oxide (NO), prostaglandin E2, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta, as well as expression of their synthesizing enzymes, inducible NO synthase, and cyclooxygenase-2.	Ropivacaine	23-34	interleukin 1 beta	Mus musculus	178-186
30625475-6	2019	RESULTS: Our results indicated that binge-like ethanol consumption resulted in a 3.6-fold increase in the proinflammatory cytokine interleukin (IL)-1beta immunoreactivity in various regions of the hippocampus.	Ethanol	47-54	interleukin 1 beta	Mus musculus	131-153
30496979-5	2019	The levels of MPO, IL-1beta, TNF-alpha and the number of F4/80+ cells in colon of DSS mice were remarkably decreased by palmatine.	palmatine	120-129	interleukin 1 beta	Mus musculus	19-27
30599892-9	2019	The mRNA expression levels of M1 macrophage-related inflammatory factors IL-6, iNOS and IL-1beta were markedly elevated in the spleens of asthmatic mice, but significantly decreased after the 8-week treatment with curcumin.	Curcumin	214-222	interleukin 1 beta	Mus musculus	88-96
29997055-7	2019	Furthermore, eugenol (150 mg/kg) was able to inhibit the release of inflammatory cytokines (TNF-alpha, IL-1beta and IL-6), NADPH oxidase activity, as well as antioxidant enzymes activity (superoxide dismutase, catalase and glutathione peroxidase).	Eugenol	13-20	interleukin 1 beta	Mus musculus	103-111
30599909-7	2019	RESULTS: Our results showed that Curcumin markedly reduced the mRNA expression and secretion of IL-1beta, IL-6, TNFalpha and MCP-1 in LPS stimulated RAW264.7 cell and the supernatant.	Curcumin	33-41	interleukin 1 beta	Mus musculus	96-104
30326393-6	2019	In vivo investigation showed that gamma-GC reduced sepsis lethality and attenuated systemic inflammatory responses in mice, as well as inhibited lipopolysaccharide (LPS)-stimulated production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), high-mobility group box 1 (HMGB1), and nitric oxide (NO) and the expression of inducible NO synthase and cyclooxygenase 2 in RAW264.7 cells.	gamma-glutamylcysteine	34-42	interleukin 1 beta	Mus musculus	236-253
30326393-6	2019	In vivo investigation showed that gamma-GC reduced sepsis lethality and attenuated systemic inflammatory responses in mice, as well as inhibited lipopolysaccharide (LPS)-stimulated production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), high-mobility group box 1 (HMGB1), and nitric oxide (NO) and the expression of inducible NO synthase and cyclooxygenase 2 in RAW264.7 cells.	gamma-glutamylcysteine	34-42	interleukin 1 beta	Mus musculus	255-263
30599908-12	2019	Additionally, the carrageenan-induced increases in TNF-alpha, IL-6, IL-1beta, PGE2 and NO productions, and COX-2 and iNOS mRNA expressions were effectually and concentration-dependently suppressed by OBB and BBR pretreatment.	Carrageenan	18-29	interleukin 1 beta	Mus musculus	68-76
29370574-4	2019	It was found that ticagrelor could inhibit platelet activity, decrease the levels of interleukin-1beta and serum creatinine, reduce infiltration of neutrophils in renal tissue, and attenuate cell apoptosis in the kidney.	Ticagrelor	18-28	interleukin 1 beta	Mus musculus	85-102
30602693-3	2018	Baicalein pretreatment significantly alleviated the elevation of IL-6, IL-1beta and TNF-alpha in serum and hepatic in a dose-dependent manner.	baicalein	0-9	interleukin 1 beta	Mus musculus	71-79
29438224-8	2019	Both the ELISA and western blot results showed that erlotinib attenuated the expression of TNF-alpha and IL-1beta in LPS-induced ALI in mice.	Erlotinib Hydrochloride	52-61	interleukin 1 beta	Mus musculus	105-113
30586442-0	2018	Tumor-secreted factors induce IL-1beta maturation via the glucose-mediated synergistic axis of mTOR and NF-kappaB pathways in mouse macrophages.	Glucose	58-65	interleukin 1 beta	Mus musculus	30-38
30687752-8	2018	Oridonin treatment significantly inhibited LPS-induced proinflammatory cytokines IL-1beta, IL-6, and MCP-1 production as well as cell adhesion molecules ICAM-1 and VCAM-1.	oridonin	0-8	interleukin 1 beta	Mus musculus	81-89
30586442-7	2018	TCM increased the levels of IL-1beta via glucose-mediated activation of the inflammasome.	Glucose	41-48	interleukin 1 beta	Mus musculus	28-36
30586442-11	2018	Finally, glucose inhibition by inoculation with 2-deoxy-D-glucose in vivo decreased the IL-1beta levels in both the blood and tumor region of B16F10-bearing C57BL/6 mice relative to those in PBS-injected tumor-bearing mice.	Glucose	9-16	interleukin 1 beta	Mus musculus	88-96
30586442-11	2018	Finally, glucose inhibition by inoculation with 2-deoxy-D-glucose in vivo decreased the IL-1beta levels in both the blood and tumor region of B16F10-bearing C57BL/6 mice relative to those in PBS-injected tumor-bearing mice.	Deoxyglucose	48-65	interleukin 1 beta	Mus musculus	88-96
30586442-12	2018	These results suggest that glucose supplied from blood vessels might be important for IL-1beta production in tumor-associated macrophages via the integrated signals of the NF-kappaB and mTOR pathways in the tumor microenvironment.	Glucose	27-34	interleukin 1 beta	Mus musculus	86-94
30098377-10	2018	Furthermore, we also found exposure of IL-1beta to HK-2 cells induced ROS generation and expression of TXNIP and Nox4.	Reactive Oxygen Species	70-73	interleukin 1 beta	Mus musculus	39-47
30662512-12	2018	Moreover, the Cs-C-Q80 treatments inhibited rUCCAO-induced astrocytes activation and the tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta expression, indicating the anti-inflammatory roles of Cs-C-Q80 against subcortical ischemia.	cs-c-q80	14-22	interleukin 1 beta	Mus musculus	133-150
30352316-7	2018	Salmeterol inhibited LPS-induced release of the pro-inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and nitric oxide from BV2 cells.	Salmeterol Xinafoate	0-10	interleukin 1 beta	Mus musculus	124-141
30352316-7	2018	Salmeterol inhibited LPS-induced release of the pro-inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and nitric oxide from BV2 cells.	Salmeterol Xinafoate	0-10	interleukin 1 beta	Mus musculus	143-151
30618760-8	2018	Moreover, costunolide significantly decreased the protein expression of proinflammatory cytokines including interleukin 1beta, interleukin 6, and tumor necrosis factor.	costunolide	10-21	interleukin 1 beta	Mus musculus	108-125
30567499-5	2018	ALA treatment resulted in the attenuation of iNOS and NO expression and the downregulation of proinflammatory cytokines (TNF-alpha, cyclooxygenase2, IL-1beta, IL-6).	5-amino levulinic acid	0-3	interleukin 1 beta	Mus musculus	149-157
30531925-7	2018	In a mouse model of brain injury conducted in GFAP-GFP mice, DPTIP potently (10 mg/kg IP) inhibited IL-1beta-induced astrocyte-derived EV release (51 +- 13%; p &lt; 0.001).	DPTIP	61-66	interleukin 1 beta	Mus musculus	100-108
30420491-9	2018	Moreover, glucose treatment promoted mRNA levels of TNF-alpha, IL-1beta, and IL-6 in mesangial cells.	Glucose	10-17	interleukin 1 beta	Mus musculus	63-71
30399421-6	2018	The results demonstrated that artemisinin B inhibited NO secretion from LPS-induced BV2 cells and significantly reduced the expression levels of the inflammatory cytokines IL-1beta, IL-6 and TNF-alpha.	artemisinin B	30-43	interleukin 1 beta	Mus musculus	172-180
30558188-12	2018	Moreover, puerarin-V treatment reduces the inflammatory milieu in the heart of MI mice, thereby blocking the upregulation of proinflammatory cytokines (TNF-alpha, IL-1beta and IL-6).	puerarin-v	10-20	interleukin 1 beta	Mus musculus	163-171
30448177-9	2018	Lung histopathological changes, W/D ratio, TNF-alpha, IL-1beta and protein content in BALF induced by LPS were effectively ameliorated by H2S and autophagy inhibitor 3-methyladenine.	Hydrogen Sulfide	138-141	interleukin 1 beta	Mus musculus	54-62
30448177-9	2018	Lung histopathological changes, W/D ratio, TNF-alpha, IL-1beta and protein content in BALF induced by LPS were effectively ameliorated by H2S and autophagy inhibitor 3-methyladenine.	3-methyladenine	166-181	interleukin 1 beta	Mus musculus	54-62
30172058-12	2018	JGSQW, loganin, and paeoniflorin inhibited the ICAM-1 gene expression caused by the IL-1beta stimulation of A549 cells, and loganin and paeoniflorin had the maximum inhibitory effect when mixed according to the combination of doses in JGSQW.	loganin	7-14	interleukin 1 beta	Mus musculus	84-92
30564782-7	2018	Self-cleavage at the D285 site is required to generate the fully active caspase-11 protease (proposed here to be p32/p10) that mediates gasdermin D cleavage, macrophage death, and NLRP3-dependent IL-1beta production.	d285	21-25	interleukin 1 beta	Mus musculus	196-204
30172058-12	2018	JGSQW, loganin, and paeoniflorin inhibited the ICAM-1 gene expression caused by the IL-1beta stimulation of A549 cells, and loganin and paeoniflorin had the maximum inhibitory effect when mixed according to the combination of doses in JGSQW.	peoniflorin	20-32	interleukin 1 beta	Mus musculus	84-92
30326372-6	2018	The compounds 9h and 9k also decreased liposaccharide (LPS)-induced IL-6, IL-1beta and vascular cell adhesion molecule-1 (VCAM-1) mRNA expression, both in vitro and in an in vivo model of ALI.	liposaccharide	39-53	interleukin 1 beta	Mus musculus	74-82
30524506-11	2018	Oral administration of beta-glucans to mice decreased the overgrowth of aerobic bacteria and IL-1beta expression while L. johnsonii and B. thetaiotaomicron populations increased significantly.	beta-Glucans	23-35	interleukin 1 beta	Mus musculus	93-101
30326372-6	2018	The compounds 9h and 9k also decreased liposaccharide (LPS)-induced IL-6, IL-1beta and vascular cell adhesion molecule-1 (VCAM-1) mRNA expression, both in vitro and in an in vivo model of ALI.	lps	55-58	interleukin 1 beta	Mus musculus	74-82
30172058-12	2018	JGSQW, loganin, and paeoniflorin inhibited the ICAM-1 gene expression caused by the IL-1beta stimulation of A549 cells, and loganin and paeoniflorin had the maximum inhibitory effect when mixed according to the combination of doses in JGSQW.	peoniflorin	136-148	interleukin 1 beta	Mus musculus	84-92
30426751-3	2018	Supplemental resveratrol (0.1% (w/w) in the diet) partially or totally reversed these symptoms (body weight change 100 +- 1, colon length 4.6 +- 0.1; IL-1beta 5.9 +- 1.8, IL-6 10 +- 3, CXCL-2 14 +- 7, occludin 0.76 +- 0.06, neutrophil infiltration 9.3 +- 0.7, p &lt; 0.05).	Resveratrol	13-24	interleukin 1 beta	Mus musculus	150-158
30564235-2	2018	Cutaneous exposure to Imiquimod (IMQ), a TLR7 agonist, induced acute expression of pro-inflammatory factors (IL1beta, IL6, CXCL1) and neutrophil influx equally in both wildtype and Mmp10 -/- mice.	Imiquimod	22-31	interleukin 1 beta	Mus musculus	109-116
30564235-2	2018	Cutaneous exposure to Imiquimod (IMQ), a TLR7 agonist, induced acute expression of pro-inflammatory factors (IL1beta, IL6, CXCL1) and neutrophil influx equally in both wildtype and Mmp10 -/- mice.	Imiquimod	33-36	interleukin 1 beta	Mus musculus	109-116
30243084-10	2018	Melatonin reduced DEHP-induced elevation of NO, MDA, IL-1beta and TNF-alpha levels.	Melatonin	0-9	interleukin 1 beta	Mus musculus	53-61
30273598-2	2018	We first demonstrated that 7-ketocholesterol stimulated Nlrp3 inflammasome formation and activation as shown by increased colocalization of inflammasome components [Nlrp3 versus apoptosis associated speck-like protein (Asc) or caspase-1] and enhanced cleavage of caspase-1 into active caspase-1 to generate IL-1beta in coronary artery smooth muscle cells.	7-ketocholesterol	27-44	interleukin 1 beta	Mus musculus	307-315
30395837-1	2018	Mast cells and Kupffer cells secrete interleukin (IL)-1beta, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha, which stimulate excess nitric oxide (NO) producing-inducible NO synthase (iNOS).	Nitric Oxide	147-159	interleukin 1 beta	Mus musculus	37-59
30622665-13	2018	Filtered water treatment suppressed proinflammatory cytokines and decreased the mRNA expression of TNF-alpha, IL-6, IL-1beta, and NF-kappaB P65.	Water	9-14	interleukin 1 beta	Mus musculus	116-124
30312858-16	2018	The expressions of inflammatory cytokine genes, IL-1beta, IL-6, and TNF-alpha, were also significantly increased in the frontal cortex of male, but not female, offspring of ethanol-fed dams.	Ethanol	173-180	interleukin 1 beta	Mus musculus	48-56
30143934-5	2018	In vitro, HMA suppressed the production NO, TGF-beta1, TNF-alpha, IL-6, and IL-1beta in LPS-stimulated RAW 264.7 macrophage cells.	2-(hydroxymethyl)anthraquinone	10-13	interleukin 1 beta	Mus musculus	76-84
30184260-10	2018	In particular, minocycline initially enhanced IL-1beta, IL-6, IL-22, GM-CSF and IL-4 colonic production and monocyte recruitment to the intestine, subsequently increasing Ly6C- MHCII+ macrophages, Tregs and type 2 intestinal immune responses.	Minocycline	15-26	interleukin 1 beta	Mus musculus	46-54
30372845-6	2018	Furthermore, DTF was more potent than etanercept in suppressing the expression of inflammatory factors (IL-17 A, IL-6, IL-1beta, IL-23, IL-22 and IL-12) in the serum, spleen and psoriasis-like skin compared with etanercept at the same dose.	dtf	13-16	interleukin 1 beta	Mus musculus	119-127
30145061-7	2018	By quantifying the production of Nitric oxide (NO), we further report that the pretreatment of IL-1beta fails to produce the nitric oxide.	Nitric Oxide	33-45	interleukin 1 beta	Mus musculus	95-103
30003404-5	2018	The production of TNF-alpha and IL-1beta in the BALF was suppressed by the treatment of terpinen-4-ol.	terpinenol-4	88-101	interleukin 1 beta	Mus musculus	32-40
30145653-6	2018	qPCR and ELISA assays indicated that nuciferine dose-dependently reduced the levels of TNF-alpha and IL-1beta, which indicated that nuciferine might have therapeutic effects on mastitis.	nuciferine	37-47	interleukin 1 beta	Mus musculus	101-109
30312879-8	2018	In agreement to its in vitro action, treatment with 100 mg/kg of LASSBio-1386 reduced TNF-alpha and IL-1beta serum levels, while increased IL-6 and IL-10.	N'-(3,4-dimethoxybenzylidene)-4-methoxybenzohydrazide	65-77	interleukin 1 beta	Mus musculus	100-108
30273917-0	2018	Leonurine inhibits IL-1beta induced inflammation in murine chondrocytes and ameliorates murine osteoarthritis.	leonurine	0-9	interleukin 1 beta	Mus musculus	19-27
30273917-8	2018	In this study, leonurine visibly inhibited the IL-1beta-induced production of NO, PGE2, IL-6 and TNF-alpha; and decreased the expression of iNOS, COX-2, MMP-3, MMP-13 and ADAMTS-5 in chondrocytes.	leonurine	15-24	interleukin 1 beta	Mus musculus	47-55
30145653-6	2018	qPCR and ELISA assays indicated that nuciferine dose-dependently reduced the levels of TNF-alpha and IL-1beta, which indicated that nuciferine might have therapeutic effects on mastitis.	nuciferine	132-142	interleukin 1 beta	Mus musculus	101-109
30273917-8	2018	In this study, leonurine visibly inhibited the IL-1beta-induced production of NO, PGE2, IL-6 and TNF-alpha; and decreased the expression of iNOS, COX-2, MMP-3, MMP-13 and ADAMTS-5 in chondrocytes.	Dinoprostone	82-86	interleukin 1 beta	Mus musculus	47-55
30133699-6	2018	We also identified that AIM2 is highly expressed in Kupffer cells, and that AIM2-mediated production of IL-1beta by these cells is enhanced after DEN-induced liver damage.	Diethylnitrosamine	146-149	interleukin 1 beta	Mus musculus	104-112
30273917-9	2018	Furthermore, leonurine significantly suppressed IL-1beta-stimulated NF-kappaB activation.	leonurine	13-22	interleukin 1 beta	Mus musculus	48-56
30388519-8	2018	RESULTS: In pristane-injected mice, piperine significantly ameliorated LN development in a dose-dependent manner, which was associated with the inhibition of NLRP3 inflammasome and the reduction of serum IL-1beta, but not of IL-18 level.	piperine	36-44	interleukin 1 beta	Mus musculus	204-212
30387829-7	2018	The results demonstrated that PA effectively activated NLRP3 inflammasome and increased the expression and secretion of interleukin (IL)-1beta and IL-18.	Palmitic Acid	30-32	interleukin 1 beta	Mus musculus	120-142
30336207-7	2018	Our results showed that administration of Tenofovir disoproxil fumarate and Nevirapine induced astrogliosis and up-regulated IL-1beta and TNF-alpha.	Tenofovir	42-71	interleukin 1 beta	Mus musculus	125-133
30336207-7	2018	Our results showed that administration of Tenofovir disoproxil fumarate and Nevirapine induced astrogliosis and up-regulated IL-1beta and TNF-alpha.	Nevirapine	76-86	interleukin 1 beta	Mus musculus	125-133
30355787-5	2018	The IL-1beta-dependent induction of cyclooxygenase 2 (COX2) and the secretion of PGE2 was reduced in mouse embryonic fibroblasts and intestinal myofibroblasts (IMFs) from ABIN2[D310N] mice.	Dinoprostone	81-85	interleukin 1 beta	Mus musculus	4-12
30355787-12	2018	USA 111: E4658-E4667), but the IL-1beta-dependent production of COX2 and PGE2 in mouse embryonic fibroblasts or IMFs was unaffected by pharmacological inhibition of Tpl2 in wild-type mice.	Dinoprostone	73-77	interleukin 1 beta	Mus musculus	31-39
30396035-0	2018	Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1beta production.	Curcumin	0-8	interleukin 1 beta	Mus musculus	88-96
30396035-0	2018	Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1beta production.	Dextran Sulfate	20-23	interleukin 1 beta	Mus musculus	88-96
29667111-0	2018	Propofol specifically suppresses IL-1beta secretion but increases bacterial survival in Staphylococcus aureus-infected RAW264.7 cells.	Propofol	0-8	interleukin 1 beta	Mus musculus	33-41
29667111-3	2018	In this study, the effects of four intravenous anesthetics (propofol, thiamylal sodium, midazolam, and ketamine) on IL-1beta secretion, ROS, and bacterial survival in S. aureus-infected RAW264.7 cells were evaluated.	Propofol	60-68	interleukin 1 beta	Mus musculus	116-124
29667111-3	2018	In this study, the effects of four intravenous anesthetics (propofol, thiamylal sodium, midazolam, and ketamine) on IL-1beta secretion, ROS, and bacterial survival in S. aureus-infected RAW264.7 cells were evaluated.	Thiamylal	70-86	interleukin 1 beta	Mus musculus	116-124
29667111-3	2018	In this study, the effects of four intravenous anesthetics (propofol, thiamylal sodium, midazolam, and ketamine) on IL-1beta secretion, ROS, and bacterial survival in S. aureus-infected RAW264.7 cells were evaluated.	Midazolam	88-97	interleukin 1 beta	Mus musculus	116-124
29667111-3	2018	In this study, the effects of four intravenous anesthetics (propofol, thiamylal sodium, midazolam, and ketamine) on IL-1beta secretion, ROS, and bacterial survival in S. aureus-infected RAW264.7 cells were evaluated.	Ketamine	103-111	interleukin 1 beta	Mus musculus	116-124
29667111-8	2018	Compared with the levels after treatment with the other intravenous anesthetics, secreted IL-1beta levels were lowest in the supernatant of S. aureus-infected RAW264.7 cell cultures after propofol treatment, but propofol did not decrease IL-1beta mRNA or protein expression.	Propofol	188-196	interleukin 1 beta	Mus musculus	90-98
29667111-9	2018	However, thiamylal sodium and midazolam decreased IL-1beta mRNA and protein expression in a dose-dependent manner.	Thiamylal	9-25	interleukin 1 beta	Mus musculus	50-58
29667111-9	2018	However, thiamylal sodium and midazolam decreased IL-1beta mRNA and protein expression in a dose-dependent manner.	Midazolam	30-39	interleukin 1 beta	Mus musculus	50-58
29667111-12	2018	Of the four intravenous anesthetics, propofol was the most potent inhibitor of IL-1beta secretion and ROS level in S. aureus-infected RAW264.7 cells; moreover, propofol resulted in an increase in bacterial survival by inhibiting ROS and phagocytosis.	Propofol	37-45	interleukin 1 beta	Mus musculus	79-87
29667111-12	2018	Of the four intravenous anesthetics, propofol was the most potent inhibitor of IL-1beta secretion and ROS level in S. aureus-infected RAW264.7 cells; moreover, propofol resulted in an increase in bacterial survival by inhibiting ROS and phagocytosis.	Propofol	160-168	interleukin 1 beta	Mus musculus	79-87
30396035-3	2018	OBJECTIVE: The present study was to investigate the protective effects of curcumin on dextran sulfate sodium (DSS)-induced colitis through inhibiting NLRP3 inflammasome activation and IL-1beta production.	Curcumin	74-82	interleukin 1 beta	Mus musculus	184-192
30396035-3	2018	OBJECTIVE: The present study was to investigate the protective effects of curcumin on dextran sulfate sodium (DSS)-induced colitis through inhibiting NLRP3 inflammasome activation and IL-1beta production.	Dextran Sulfate	86-108	interleukin 1 beta	Mus musculus	184-192
30396035-3	2018	OBJECTIVE: The present study was to investigate the protective effects of curcumin on dextran sulfate sodium (DSS)-induced colitis through inhibiting NLRP3 inflammasome activation and IL-1beta production.	Dextran Sulfate	110-113	interleukin 1 beta	Mus musculus	184-192
30396035-4	2018	METHODS: LPS-primed macrophages were treated with curcumin prior to DSS triggering NLRP3 inflammasome activation, IL-1beta secretion and ASC oligomerization were observed.	Curcumin	50-58	interleukin 1 beta	Mus musculus	114-122
30396035-9	2018	RESULTS: NLRP3 inflammasome activation was dramatically inhibited by curcumin in DSS-stimulated macrophages, as evidenced by decreased IL-1beta secretion, less caspase-1 activation and ASC specks.	Curcumin	69-77	interleukin 1 beta	Mus musculus	135-143
30396035-9	2018	RESULTS: NLRP3 inflammasome activation was dramatically inhibited by curcumin in DSS-stimulated macrophages, as evidenced by decreased IL-1beta secretion, less caspase-1 activation and ASC specks.	Dextran Sulfate	81-84	interleukin 1 beta	Mus musculus	135-143
30396035-12	2018	Meanwhile, curcumin significantly decreased the expression of multiple inflammatory cytokines (including mature IL-1beta, IL-6, MCP-1), MPO activity, caspase-1 activity as well as histopathological damage.	Curcumin	11-19	interleukin 1 beta	Mus musculus	112-120
30387829-8	2018	Notably, the PA-induced inflammasome activation was reversed by Nob, as indicated by the decreased expression levels of NLRP3, Caspase-1, IL-1beta and IL-18.	Palmitic Acid	13-15	interleukin 1 beta	Mus musculus	138-146
30327995-7	2018	Our results showed that NJK14047 markedly reduced the production of nitric oxide and prostaglandin E2 by downregulating the expression of various proinflammatory mediators such as nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha and interleukin-1beta in LPS-induced BV2 microglia.	Nitric Oxide	68-80	interleukin 1 beta	Mus musculus	253-270
30353672-5	2018	Both gene and protein expression levels of pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha are markedly attenuated by WCP treatment in the colon of AOM/DSS-treated mice.	CHEMBL3400817	127-130	interleukin 1 beta	Mus musculus	70-78
30353672-5	2018	Both gene and protein expression levels of pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha are markedly attenuated by WCP treatment in the colon of AOM/DSS-treated mice.	Dextran Sulfate	161-164	interleukin 1 beta	Mus musculus	70-78
30327995-7	2018	Our results showed that NJK14047 markedly reduced the production of nitric oxide and prostaglandin E2 by downregulating the expression of various proinflammatory mediators such as nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha and interleukin-1beta in LPS-induced BV2 microglia.	Dinoprostone	85-101	interleukin 1 beta	Mus musculus	253-270
30555402-6	2018	Furthermore, an increased expression of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-8, and TNF-alpha, was observed in brain endothelial cells in response to oxygen/glucose depletion/reoxygenation, which was decreased by the shRNA-mediated Atg7 knockdown.	Oxygen	170-176	interleukin 1 beta	Mus musculus	78-86
30548229-8	2018	LPS increased gastrocnemius mRNA expression of TNF-alpha and IL-1beta, and protein levels of NLRP3, all of which were attenuated by imoxin.	imoxin	132-138	interleukin 1 beta	Mus musculus	61-69
30548229-9	2018	Similarly, IL-6 mRNA and IL-1beta protein were suppressed in Imoxin+LPS compared to LPS alone.	imoxin	61-67	interleukin 1 beta	Mus musculus	25-33
30556022-7	2018	Increased brain levels of IL-1beta, IL-6, and TNF-alpha in the LPS-induced mice were reduced by TPA treatment.	Tetradecanoylphorbol Acetate	96-99	interleukin 1 beta	Mus musculus	26-34
29235395-12	2018	SBTE + Rb enhanced peritoneal CD11c+ cells (25.8%) as compared to 9.4% cells in Rb immunized mice, showed 3.2-fold increment in LPS induced IL-1beta.	Rubidium	7-9	interleukin 1 beta	Mus musculus	140-148
30281174-4	2018	Licochalcone A blocked P. acnes-induced production of caspase-1(p10) and IL-1beta in primary mouse macrophages and human SZ95 sebocytes, indicating the suppression of NLRP3 inflammasome.	licochalcone	0-12	interleukin 1 beta	Mus musculus	73-81
30281174-7	2018	Licochalcone A reduced caspase-1 activity and IL-1beta production in mouse ear injected with P. acnes.	licochalcone	0-12	interleukin 1 beta	Mus musculus	46-54
30273691-7	2018	APAP-treated mice had elevated hepatic mRNA levels of inflammatory genes (Nf-kappaB, TNF-alpha, IL1-beta and IL-6), an effect blunted in those co-treated with CORM A-1.	Acetaminophen	0-4	interleukin 1 beta	Mus musculus	96-104
30555402-6	2018	Furthermore, an increased expression of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-8, and TNF-alpha, was observed in brain endothelial cells in response to oxygen/glucose depletion/reoxygenation, which was decreased by the shRNA-mediated Atg7 knockdown.	Glucose	177-184	interleukin 1 beta	Mus musculus	78-86
30463239-4	2018	The LPS-induced expression of tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) were reduced in TQ-6-treated cells.	tq-6	120-124	interleukin 1 beta	Mus musculus	74-92
30463256-0	2018	Endothelial Microsomal Prostaglandin E Synthetase-1 Upregulates Vascularity and Endothelial Interleukin-1beta in Deteriorative Progression of Experimental Autoimmune Encephalomyelitis.	Prostaglandins	23-36	interleukin 1 beta	Mus musculus	92-109
30524274-3	2018	Compared to saline-treated mice, cisplatin-intoxicated mice had significantly higher (p &lt; 0.05) serum levels of urea, creatinine, interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha.	Cisplatin	33-42	interleukin 1 beta	Mus musculus	133-150
30524274-3	2018	Compared to saline-treated mice, cisplatin-intoxicated mice had significantly higher (p &lt; 0.05) serum levels of urea, creatinine, interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha.	Cisplatin	33-42	interleukin 1 beta	Mus musculus	152-160
30249750-6	2018	The possibility of MI-2 treatment in DSS-induced colitis, associated with restoration of healthy microbially diverse populations in addition to reshaping host immune modulating capacity by reducing inflammatory cytokines (tumor necrosis factor alpha, interleukin-1beta [IL-1beta], IL-17alpha, and IL-22), may be considered therapeutic for ulcerative colitis.	MI-2	19-23	interleukin 1 beta	Mus musculus	251-268
30249750-6	2018	The possibility of MI-2 treatment in DSS-induced colitis, associated with restoration of healthy microbially diverse populations in addition to reshaping host immune modulating capacity by reducing inflammatory cytokines (tumor necrosis factor alpha, interleukin-1beta [IL-1beta], IL-17alpha, and IL-22), may be considered therapeutic for ulcerative colitis.	MI-2	19-23	interleukin 1 beta	Mus musculus	270-278
30524241-8	2018	We found that isoflurane GA caused upregulations of hippocampal NLRP3, cleaved caspase-1, interleukin-1beta (IL-1beta), and IL-18 and the activation of pyroptosis, which is NLRP3 inflammasome-dependent; this consequently gave rise to neuronal damage and cognitive impairment in aged mice.	Isoflurane	14-24	interleukin 1 beta	Mus musculus	90-107
30524241-8	2018	We found that isoflurane GA caused upregulations of hippocampal NLRP3, cleaved caspase-1, interleukin-1beta (IL-1beta), and IL-18 and the activation of pyroptosis, which is NLRP3 inflammasome-dependent; this consequently gave rise to neuronal damage and cognitive impairment in aged mice.	Isoflurane	14-24	interleukin 1 beta	Mus musculus	109-117
30463239-4	2018	The LPS-induced expression of tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) were reduced in TQ-6-treated cells.	tq-6	120-124	interleukin 1 beta	Mus musculus	94-102
29715496-4	2018	Conversely, priming with PI3K inhibitor wortmannin prevents insulin attenuation of HG- and/or LPS-induced p38 MAPK and NF-kappaB activation, Tnf-alpha, Il-1beta expression as well as NO production.	Wortmannin	40-50	interleukin 1 beta	Mus musculus	152-160
30505282-8	2018	Meanwhile, ICA decreased the production of interleukin-1 beta, tumor necrosis factor-alpha and inducible nitric oxide synthase at 24 h and 3 days after SCI.	icariin	11-14	interleukin 1 beta	Mus musculus	43-90
30581485-6	2018	STE dose-dependently inhibited the productions of inflammatory mediators (NO and PGE2) and proinflammatory cytokines (IL-1beta and IL-6) in LPS-stimulated RAW 264.7 cells.	ste	0-3	interleukin 1 beta	Mus musculus	118-126
30059880-8	2018	Exposure to DINP and/or formaldehyde also induced an increase in IL-1beta, IL-17, and NGF.	diisononyl phthalate	12-16	interleukin 1 beta	Mus musculus	65-73
30059880-8	2018	Exposure to DINP and/or formaldehyde also induced an increase in IL-1beta, IL-17, and NGF.	Formaldehyde	24-36	interleukin 1 beta	Mus musculus	65-73
30059880-9	2018	Blocking oxidative stress by administering melatonin or inhibiting NF-kappaB activation by treatment with Dehydroxymethylepoxyquinomicin effectively prevented increasing the levels IL-1beta, IL-17 and nerve growth factor.	Melatonin	43-52	interleukin 1 beta	Mus musculus	181-189
30059880-9	2018	Blocking oxidative stress by administering melatonin or inhibiting NF-kappaB activation by treatment with Dehydroxymethylepoxyquinomicin effectively prevented increasing the levels IL-1beta, IL-17 and nerve growth factor.	dehydroxymethylepoxyquinomicin	106-136	interleukin 1 beta	Mus musculus	181-189
30352242-9	2018	In addition, hesperidin decreased the levels of IL-1beta, TNF-alpha and MDA, and increased BDNF levels in the hippocampus.	Hesperidin	13-23	interleukin 1 beta	Mus musculus	48-56
30114517-8	2018	Moreover, the inhibitory effect on mRNA expression of proinflammatory cytokine IL-1beta, IL-6 and TNF-alpha of fourteen cassane diterpenes obtained from CMC extract were valued using the RAW 264.7 macrophages cell stimulated by lipopolysaccharide (LPS) assay.	Cassane	120-127	interleukin 1 beta	Mus musculus	79-87
30114517-8	2018	Moreover, the inhibitory effect on mRNA expression of proinflammatory cytokine IL-1beta, IL-6 and TNF-alpha of fourteen cassane diterpenes obtained from CMC extract were valued using the RAW 264.7 macrophages cell stimulated by lipopolysaccharide (LPS) assay.	Diterpenes	128-138	interleukin 1 beta	Mus musculus	79-87
30114517-11	2018	Fourteen cassane derivatives as the main constituents of CMC extract showed the promising activity on the expression mRNA of cytokine IL-1beta, IL-6 and TNF-alpha produced by macrophages cells.	Cassane	9-16	interleukin 1 beta	Mus musculus	134-142
30114517-11	2018	Fourteen cassane derivatives as the main constituents of CMC extract showed the promising activity on the expression mRNA of cytokine IL-1beta, IL-6 and TNF-alpha produced by macrophages cells.	cmc	57-60	interleukin 1 beta	Mus musculus	134-142
30375618-7	2018	Sesamol elevated mRNA levels and protein expressions of antioxidant enzymes HO-1 and NQO1 as well as decreased inflammatory cytokines TNF-alpha and IL-1beta in d-galactose-treated mice serum.	sesamol	0-7	interleukin 1 beta	Mus musculus	148-156
30466979-6	2018	The anti-inflammatory mechanism was explored by measuring the protein and mRNA levels of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in the ear of the TPA-treated mice.	Tetradecanoylphorbol Acetate	180-183	interleukin 1 beta	Mus musculus	130-152
30375618-7	2018	Sesamol elevated mRNA levels and protein expressions of antioxidant enzymes HO-1 and NQO1 as well as decreased inflammatory cytokines TNF-alpha and IL-1beta in d-galactose-treated mice serum.	Galactose	160-171	interleukin 1 beta	Mus musculus	148-156
30483062-10	2018	Also, we observed that clemastine regulated the imbalance of pro-inflammatory cytokines including interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) in the hippocampus and serum of depressive-like mice.	Clemastine	23-33	interleukin 1 beta	Mus musculus	98-116
30483062-10	2018	Also, we observed that clemastine regulated the imbalance of pro-inflammatory cytokines including interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) in the hippocampus and serum of depressive-like mice.	Clemastine	23-33	interleukin 1 beta	Mus musculus	118-126
30424795-14	2018	HCAR1 stimulation by lactate or ketones from the ketogenic diet reduced inflammasome formation, as shown by reduced mRNA and protein expression of NLRP3 and IL-1beta.	Lactic Acid	21-28	interleukin 1 beta	Mus musculus	157-165
30099341-3	2018	LPS plus ATP initiated IL-1beta cleavage and release in mouse peritoneal macrophages and peaked at 4 h. Leucodin did not show significant toxicity within 200 muM and effectively inhibited pro-IL-1beta cleavage and release of mature-IL-1beta in macrophages.	Adenosine Triphosphate	9-12	interleukin 1 beta	Mus musculus	23-31
30424795-14	2018	HCAR1 stimulation by lactate or ketones from the ketogenic diet reduced inflammasome formation, as shown by reduced mRNA and protein expression of NLRP3 and IL-1beta.	Ketones	32-39	interleukin 1 beta	Mus musculus	157-165
30195729-5	2018	To that end, we inhibited the production of interleukin-1beta, one of the main inflammatory cytokines involved in the neuroinflammation triggered by amyloid peptides, in a transgenic mouse model of this disease by using minocycline, a drug known to impair the synthesis of this cytokine.	Minocycline	220-231	interleukin 1 beta	Mus musculus	44-61
30195729-6	2018	Our data suggest that interleukin-1beta may be instrumental in order to achieve the beneficial effects derived of fatty acid amide hydrolase genetic inactivation.	Fatty Acids	114-124	interleukin 1 beta	Mus musculus	22-39
30195729-8	2018	We here describe a previously unknown link between the endocannabinoid system and interleukin-1beta in the context of Alzheimer"s disease that open new possibilities for the development of novel therapeutics.	Endocannabinoids	55-70	interleukin 1 beta	Mus musculus	82-99
30538802-9	2018	Here, we demonstrate that omega-9 treatment is associated with increased levels of the anti-inflammatory cytokine IL-10 and decreased levels of the proinflammatory cytokines TNF-alpha and IL-1beta in peritoneal lavage fluid of mice with sepsis.	omega-9	26-33	interleukin 1 beta	Mus musculus	188-196
30407111-6	2018	RESULTS: Box A versus PBS prophylactic treatment significantly reduced clinical scores, MPO activity, bacterial load, and expression of TLR4, RAGE, IL-1beta, CXCL2, and TNF-alpha in the infected cornea.	pbs	22-25	interleukin 1 beta	Mus musculus	148-156
30407111-9	2018	Box A versus PBS therapeutic treatment significantly reduced clinical scores, MPO activity, bacterial load, and protein levels of IL-1beta, CXCL2, and IL-6 in the infected cornea.	pbs	13-16	interleukin 1 beta	Mus musculus	130-138
30459553-6	2018	However, intraperitoneal administration of the specific HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) reduced the levels of HSP90, NLRP3, ASC, caspase-1 and IL-1beta, while increasing the levels of brain-derived neurotrophic factor and doublecortin (DCX), as well as the number of BrdU-positive cells in SAH mice.	tanespimycin	72-110	interleukin 1 beta	Mus musculus	175-183
30459553-6	2018	However, intraperitoneal administration of the specific HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) reduced the levels of HSP90, NLRP3, ASC, caspase-1 and IL-1beta, while increasing the levels of brain-derived neurotrophic factor and doublecortin (DCX), as well as the number of BrdU-positive cells in SAH mice.	tanespimycin	112-118	interleukin 1 beta	Mus musculus	175-183
30455947-12	2018	The aqueous fraction decreased the levels of inflammatory markers interleukin-6, nitric oxide, and matrix metalloproteinase 9 in the mouse mammary SCp2 cells, and the level of interleukin-1beta produced by phorbol-12-myristate-13-acetate-activated THP-1 human monocytic cells.	Tetradecanoylphorbol Acetate	206-237	interleukin 1 beta	Mus musculus	176-193
30138892-8	2018	Moreover, inhibition of miR-92a ameliorated the inflammatory response by reducing the repression of proinflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 in lung tissues.	mir-92a	24-31	interleukin 1 beta	Mus musculus	177-194
30138892-8	2018	Moreover, inhibition of miR-92a ameliorated the inflammatory response by reducing the repression of proinflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 in lung tissues.	mir-92a	24-31	interleukin 1 beta	Mus musculus	196-204
30149233-9	2018	In vivo, HABP2-8-arm PEG-COLBP treatment and the clinical HA comparator Orthovisc lowered levels of inflammatory genes including IL-6, IL-1B, and MMP13 compared to saline treated animals and increased aggrecan expression in young mice.	Polyethylene Glycols	21-24	interleukin 1 beta	Mus musculus	135-140
30150306-5	2018	The beta-cell toxin streptozotocin (STZ) elicits DDR in islets, both in vivo and ex vivo, and causes elevation of the proinflammatory molecules IL-1beta and Cxcl10.	Streptozocin	20-34	interleukin 1 beta	Mus musculus	144-152
30273785-6	2018	The serum levels of tumor necrosis factor alpha (TNF- alpha) and interleutkin-1beta (IL- 1beta) were significantly lowered by anacardic acid.	anacardic acid	126-140	interleukin 1 beta	Mus musculus	85-94
30273785-7	2018	In vitro assays demonstrated that anacardic acid impaired the proliferation and invasion abilities of RA-FLSs in the presence of TNF- alpha or IL- 1beta.	anacardic acid	34-48	interleukin 1 beta	Mus musculus	143-152
30150306-5	2018	The beta-cell toxin streptozotocin (STZ) elicits DDR in islets, both in vivo and ex vivo, and causes elevation of the proinflammatory molecules IL-1beta and Cxcl10.	Streptozocin	36-39	interleukin 1 beta	Mus musculus	144-152
30236973-13	2018	In 30min, CHX treatment significantly increased the secretion of interleukin (IL)-1beta and IL-8, but slightly increased the secretion of IL-10, while MMP8-I caused no change in cytokines.	Chlorhexidine	10-13	interleukin 1 beta	Mus musculus	65-87
30169672-7	2018	STZ-treated mice also showed a trend towards an increase in TNF-alpha and IL1-B inflammatory cytokines, which have previously been shown to influence protein glycosylation.	Streptozocin	0-3	interleukin 1 beta	Mus musculus	74-79
30169894-6	2018	We have demonstrated that FKBP51 silencing in a bronchial epithelial cell line resulted in a 10-fold increased potency for dexamethasone towards IL1beta-induced IL6 and IL8, whilst FKBP51 over-expression of FKBP51 reduced significantly the prednisolone sensitivity in a murine HDM-driven pulmonary inflammation model.	Dexamethasone	123-136	interleukin 1 beta	Mus musculus	145-152
30169894-6	2018	We have demonstrated that FKBP51 silencing in a bronchial epithelial cell line resulted in a 10-fold increased potency for dexamethasone towards IL1beta-induced IL6 and IL8, whilst FKBP51 over-expression of FKBP51 reduced significantly the prednisolone sensitivity in a murine HDM-driven pulmonary inflammation model.	Prednisolone	240-252	interleukin 1 beta	Mus musculus	145-152
30375063-8	2018	We found up-regulation of proinflammatory cytokine genes including Il1b, Il6 and Tnfa, among which Tnfa was selectively blocked by minocycline.	Minocycline	131-142	interleukin 1 beta	Mus musculus	67-71
30173053-5	2018	In addition, piceatannol reduced the expression of proinflammatory cytokines, including TNF-alpha, IL-1beta and IL-6, the expression of ER stress markers CHOP and phosphorylated-IRE1alpha, and the generation of oxidative stress in D-GalN/LPS-treated mouse liver.	3,3',4,5'-tetrahydroxystilbene	13-24	interleukin 1 beta	Mus musculus	99-107
30170255-5	2018	The results showed that melatonin inhibited LPS-induced pathologic changes, Myeloperoxidase (MPO) activity, and levels of interleukin-1 beta (IL-1beta).	Melatonin	24-33	interleukin 1 beta	Mus musculus	122-140
30173054-5	2018	The results showed that barbaloin decreased the phosphorylation levels of IkappaBalpha and NF-kappaB p65, leading to a reduction in the expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6).	barbaloin	24-33	interleukin 1 beta	Mus musculus	189-197
30170255-5	2018	The results showed that melatonin inhibited LPS-induced pathologic changes, Myeloperoxidase (MPO) activity, and levels of interleukin-1 beta (IL-1beta).	Melatonin	24-33	interleukin 1 beta	Mus musculus	142-150
30362468-10	2018	SIN reduced CUMS-induced increases in the levels of IL-1beta, IL-6, and TNF-alpha in the hippocampus of mice.	cums	12-16	interleukin 1 beta	Mus musculus	52-60
30266768-2	2018	Neutrophils also have functional NLRP3 and NLRC4 inflammasomes that can process pro-IL-1beta to the bioactive 17-kDa form.	17-kda	110-116	interleukin 1 beta	Mus musculus	84-92
30464588-8	2018	Furthermore, CAPE suppressed the phosphorylation of p38 mitogen-activated protein kinase, inhibited the translocation of NF-kappaB and decreased the expression of proinflammatory cytokines tumor necrosis factor-alpha, IL-1beta and IL-6.	caffeic acid phenethyl ester	13-17	interleukin 1 beta	Mus musculus	218-226
30402026-9	2018	High-dose fimasartan treatment attenuated the upregulation of TNF-alpha, interleukin (IL)-1beta, and IL-6 in ischemic kidneys.	fimasartan	10-20	interleukin 1 beta	Mus musculus	73-95
30152849-7	2018	However, blocking p38 MAPK signaling through the inhibitor SB203580 significantly suppressed the acute lung injury and excessive lung inflammation in vivo, consistent with the reduced expression of the NLRP3 inflammasome and IL-1beta and cleavage of caspase-1.	SB 203580	59-67	interleukin 1 beta	Mus musculus	225-233
30219503-5	2018	Carbon tetrachloride induced hepatic fibrosis observed through increased inflammatory (TNF-alpha, IL-1beta, COX-2, NO and iNOS) and fibrotic markers (TGF-beta and TIMP-1), changes in the hepatic morphology, high presence of collagen fibers and elevated serum levels of AST, ALT and ALP.	Carbon Tetrachloride	0-20	interleukin 1 beta	Mus musculus	98-106
30268856-7	2018	Moreover, celastrol reduced the renal mRNA expression levels of tumor necrosis factor-alpha, interleukin-1beta, P2RX7, F4/80, CD68, transforming growth factor-beta, collagen-1, and fibronectin, which were high in the Pkd1 miR TG mice.	celastrol	10-19	interleukin 1 beta	Mus musculus	93-110
30541648-19	2018	CONCLUSIONS: Pannexin-1 may be involved in LPS and MV induced lung injury, which may be regulated by intracellular release of ATP to the extracellular site and binding to P2X7 receptor on the cell surface, thereby regulating active caspase-1 production and release, involving in the production of IL-1beta and other inflammatory factors eventually which leads to the occurrence and development of lung injury.	Adenosine Triphosphate	126-129	interleukin 1 beta	Mus musculus	297-305
30459609-11	2018	In addition, pravastatin inhibited levels of epithelial-derived inflammatory cytokines including IL-6, IL-1beta, and TNF-alpha in irradiated InEpC cells.	Pravastatin	13-24	interleukin 1 beta	Mus musculus	103-111
30340603-13	2018	Notably, Guilu Erxian Liquid (100 mg/kg/day) treatment significantly reduced the mRNA levels of IL-1beta, IL-6, and TNF-alpha as well as relative the protein expression of IL-1beta and TNF-alpha to the effect of celecoxib.	Celecoxib	212-221	interleukin 1 beta	Mus musculus	172-180
30410469-8	2018	The results showed that sodium butyrate treatment decreased blood glucose and serum IL-1beta, improved the islet morphology and decreased inflammatory cell infiltration, restored the unbalanced Th1/Th2 ratio, and down-regulated Th17 to normal level.	Butyric Acid	24-39	interleukin 1 beta	Mus musculus	84-92
30498366-7	2018	This inhibitory effect was associated with the inhibition of TPA-induced upregulation of proinflammatory cytokines IL-1beta, TNF-alpha, and COX-2.	Tetradecanoylphorbol Acetate	61-64	interleukin 1 beta	Mus musculus	115-123
30340603-15	2018	CONCLUSIONS: As expected, our findings suggest that the anti-inflammatory effects of Guilu Erxian Liquid (GE-L), following marked decrease on both IL-1beta and TNF-alpha during the early course of post-traumatic osteoarthrosis (OA), may be of potential value in the treatment of osteoarthritis.	guilu erxian liquid	85-104	interleukin 1 beta	Mus musculus	147-155
30340603-13	2018	Notably, Guilu Erxian Liquid (100 mg/kg/day) treatment significantly reduced the mRNA levels of IL-1beta, IL-6, and TNF-alpha as well as relative the protein expression of IL-1beta and TNF-alpha to the effect of celecoxib.	guilu erxian liquid	9-28	interleukin 1 beta	Mus musculus	96-104
30340603-13	2018	Notably, Guilu Erxian Liquid (100 mg/kg/day) treatment significantly reduced the mRNA levels of IL-1beta, IL-6, and TNF-alpha as well as relative the protein expression of IL-1beta and TNF-alpha to the effect of celecoxib.	guilu erxian liquid	9-28	interleukin 1 beta	Mus musculus	172-180
30249753-8	2018	Furthermore, pretreatment with FM0807 inhibited the inflammatory factor tumor necrosis factor-alpha (TNF-alpha), interleukin (IL) 1beta (IL-1beta), IL-6, and inducible nitric oxide synthase (iNOS) at the protein and gene levels.	fm0807	31-37	interleukin 1 beta	Mus musculus	113-135
30249753-8	2018	Furthermore, pretreatment with FM0807 inhibited the inflammatory factor tumor necrosis factor-alpha (TNF-alpha), interleukin (IL) 1beta (IL-1beta), IL-6, and inducible nitric oxide synthase (iNOS) at the protein and gene levels.	fm0807	31-37	interleukin 1 beta	Mus musculus	137-145
29784301-5	2018	Furthermore, ganoduriporol A was demonstrated to inhibit the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) through the suppression of COX-2, MAPK and NF-kappaB signaling pathway in LPS-induced macrophage cells.	ganoduriporol a	13-28	interleukin 1 beta	Mus musculus	116-133
29886252-10	2018	Ac-YVAD-cmk treatment inhibited pyroptosis in injured BMVECs by suppressing the expression of essential inflammasome subunit - Caspase-1 and pivotal downstream pro-inflammatory cytokines (IL-1beta and IL-18), as well as hindering GSDMD cleavage and ASC oligomerization.	ac-yvad	0-7	interleukin 1 beta	Mus musculus	188-196
30410928-6	2018	Our results showed that AC-YVAD-CMK could reduce caspase-1 activation and inhibit IL-1beta production and maturation, but has no effect on NLRP3 expression, an upstream inflammatory complex.	ac-yvad	24-31	interleukin 1 beta	Mus musculus	82-90
29784301-5	2018	Furthermore, ganoduriporol A was demonstrated to inhibit the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and prostaglandin E2 (PGE2) through the suppression of COX-2, MAPK and NF-kappaB signaling pathway in LPS-induced macrophage cells.	ganoduriporol a	13-28	interleukin 1 beta	Mus musculus	135-143
29849131-9	2018	Moreover, SM934 administration dose-dependently decreased the mRNA and protein levels of DSS-induced pro-inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha), and the percentage of macrophages and neutrophils in colon tissues.	Dextran Sulfate	89-92	interleukin 1 beta	Mus musculus	129-137
30099064-6	2018	Analysis of cytokine secretion after BMM activation with heat-killed (hk) salmonellae showed that BaP exposure resulted in suppressed secretion of interleukin (IL)-1beta, IL-6 and the chemokine CXC motif ligand 1 (CXCL1).	Benzo(a)pyrene	98-101	interleukin 1 beta	Mus musculus	147-169
29788103-6	2018	Following tMCAO, cerebral IL-1beta levels, unlike tumour necrosis factor-alpha, were increased underscoring a role for this cytokine.	tmcao	10-15	interleukin 1 beta	Mus musculus	26-34
29788103-7	2018	Post-ischaemic treatment with IL-1beta antibody reduced infarct size, cerebral oedema and improved neurological performance as assessed by 2,3,5-triphenyltetrazolium chloride staining, Bederson and RotaRod tests.	triphenyltetrazolium	139-174	interleukin 1 beta	Mus musculus	30-38
29788103-9	2018	Noteworthy, tMCAO associated vascular endothelial-cadherin reduction was blunted in IL-1beta antibody-treated mice compared to vehicle-treated, likely providing the mechanistic explanation for the improved outcome.	tmcao	12-17	interleukin 1 beta	Mus musculus	84-92
30333752-9	2018	Importantly, trans-Chalcone reduced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activation and thereby the mRNA expression of the inflammasome components Nlrp3 (cryopyrin), Asc (apoptosis-associated speck-like protein containing a CARD), Pro-caspase-1 and Pro-IL-1beta.	Chalcone	13-27	interleukin 1 beta	Mus musculus	291-299
30333752-10	2018	In vitro, trans-Chalcone reduced the MSU-induced release of IL-1beta in lipopolysaccharide (LPS)-primed macrophages.	Chalcone	10-24	interleukin 1 beta	Mus musculus	60-68
30333752-10	2018	In vitro, trans-Chalcone reduced the MSU-induced release of IL-1beta in lipopolysaccharide (LPS)-primed macrophages.	msu	37-40	interleukin 1 beta	Mus musculus	60-68
30130525-7	2018	Trigonelline significantly declined the levels of blood glucose, serum tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta, while increased the levels of serum insulin and adiponectin in diabetic mice.	trigonelline	0-12	interleukin 1 beta	Mus musculus	119-136
30026058-9	2018	Finally, dexamethasone protects against the two hit mediated cognitive impairment by lowering the pro-inflammatory factors (TNF-alpha/IL-1beta) both in lungs and blood.	Dexamethasone	9-22	interleukin 1 beta	Mus musculus	134-142
29952221-10	2018	Iloprost and nimesulide reduced hyperoxia-induced increases in MPO and some cytokines (IL-1beta and TNF-alpha) but not others (IL-6 and KC/Gro).	Iloprost	0-8	interleukin 1 beta	Mus musculus	87-95
29952221-10	2018	Iloprost and nimesulide reduced hyperoxia-induced increases in MPO and some cytokines (IL-1beta and TNF-alpha) but not others (IL-6 and KC/Gro).	nimesulide	13-23	interleukin 1 beta	Mus musculus	87-95
30119266-7	2018	Simultaneously, the levels of interleukin (IL-1beta) and tumor necrosis factor (TNF-alpha) in serum and liver tissues were both attenuated by betulin.	betulin	142-149	interleukin 1 beta	Mus musculus	43-51
30233733-11	2018	The results of ELISA revealed that LPS significantly upregulated the release of TNF-alpha, IL-1beta and IL-10, which were repressed by fentanyl pretreatment.	Fentanyl	135-143	interleukin 1 beta	Mus musculus	91-99
30114748-0	2018	AlCl3 inhibits LPS-induced NLRP3 inflammasome activation and IL-1beta production through suppressing NF-kappaB signaling pathway in murine peritoneal macrophages.	Aluminum Chloride	0-5	interleukin 1 beta	Mus musculus	61-69
30114748-5	2018	Besides, AlCl3 exposure restrained the LPS-induced NLR pyrin domain containing 3 (NLRP3) inflammasome activation presented as NLRP3 expressions reduction, caspase-1 cleavage inhibition and interleukin 1 beta (IL-1beta) maturation lessened.	Aluminum Chloride	9-14	interleukin 1 beta	Mus musculus	189-207
30114748-5	2018	Besides, AlCl3 exposure restrained the LPS-induced NLR pyrin domain containing 3 (NLRP3) inflammasome activation presented as NLRP3 expressions reduction, caspase-1 cleavage inhibition and interleukin 1 beta (IL-1beta) maturation lessened.	Aluminum Chloride	9-14	interleukin 1 beta	Mus musculus	209-217
30056145-4	2018	MDA and protein carbonyl content of liver homogenate were induced by CCl4 and anthocyanin treated group reduced both significantly.Monocyte chemoattractant protein 1 (MCP1), Interleukin 1 beta (IL1beta), macrophage inflammatory protein 2 (MIP-2) were induced by CCl4 were attenuated by anthocyanin.	Anthocyanins	78-89	interleukin 1 beta	Mus musculus	194-201
29429001-7	2018	Topical application of EOCl produced anti-inflammatory effects by reducing ear thickness, ear weight and ameliorating the level of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1beta) at protein and mRNA levels as well as regulating the overproduction of oxidative markers and restoring the histopathological damage in a TPA-induced mouse model of inflammation.	eocl	23-27	interleukin 1 beta	Mus musculus	176-184
29577374-9	2018	The stereoisomer (+)-cis-EC decreased levels of proinflammatory cytokines IL-1beta, IL-6, and TNFalpha, whereas comparatively (-)-cis-EC did not reduce IL-1beta levels.	(+)-cis-ec	17-27	interleukin 1 beta	Mus musculus	74-82
29737477-9	2018	We found that CTS increased the expression of genes encoding COX-2, IL-1beta, and TNF-alpha and activated the phosphorylation of FAK, p-38, ERK, and JNK.	castanospermine	14-17	interleukin 1 beta	Mus musculus	68-76
29737477-10	2018	Pretreatment with an FAK inhibitor for 2 h reduced the expression of genes encoding COX-2, IL-1beta, and TNF-alpha induced by CTS-associated inflammation and decreased phosphorylation of FAK, p-38, ERK, and JNK.	castanospermine	126-129	interleukin 1 beta	Mus musculus	91-99
30100034-7	2018	RESULTS: Capsaicin pretreatment reduced wet-to-dry ratio, pathologic score, alveolar-arterial oxygen gradient (A-aDO2), and IL1beta, IL6, and TNFalpha levels in WT mice, with no effects in KO mice.	Capsaicin	9-18	interleukin 1 beta	Mus musculus	124-131
30488739-11	2018	Finally, we found nuclear factor-kappa B (NF-kappaB) inhibitor BAY 11-7082 further decreased secretion levels of TNF-alpha, IL-1beta, and IL-6 and increased IL-10 level.	3-(4-methylphenylsulfonyl)-2-propenenitrile	63-74	interleukin 1 beta	Mus musculus	124-132
30109356-11	2018	Pro-inflammatory cytokines such as IL-17, IL-6 and IL-1beta were decreased, while immunosuppressive factors such as TGF-beta and IL-10 were increased in CIA mice treated with quetiapine.	Quetiapine Fumarate	175-185	interleukin 1 beta	Mus musculus	51-59
30056259-4	2018	The results demonstrated that nuciferine significantly inhibited LPS-induced TNF-alpha, IL-1beta, PGE2 and NO secretion.	nuciferine	30-40	interleukin 1 beta	Mus musculus	88-96
30056259-7	2018	Functional aspects were analyzed using PPAR-gamma specific inhibitor GW9662, which attenuated the LPS-induced secretion of proinflammatory mediators, such as TNF-alpha, IL-1beta, PGE2, and NO.	2-chloro-5-nitrobenzanilide	69-75	interleukin 1 beta	Mus musculus	169-177
30066904-8	2018	It was identified that aloin decreased the level of LPS-induced iNOS expression, inhibiting the release of interleukin (IL)-1beta, IL-6, tumour necrosis factor-alpha and NO dose-dependently.	alloin	23-28	interleukin 1 beta	Mus musculus	107-129
29729431-11	2018	Coadministration of AM1241 (3 mg/kg) reduced the production of interleukin-1beta, tumor necrosis factor-alpha, and interleukin-6 induced by long-term and acute morphine treatment.	AM 1241	20-26	interleukin 1 beta	Mus musculus	63-109
29729431-11	2018	Coadministration of AM1241 (3 mg/kg) reduced the production of interleukin-1beta, tumor necrosis factor-alpha, and interleukin-6 induced by long-term and acute morphine treatment.	Morphine	160-168	interleukin 1 beta	Mus musculus	63-109
30009971-5	2018	ISO also inhibited LPS-induced MPO activity, MDA content, lung W/D ratio, and the production of inflammatory cytokines TNF-alpha and IL-1beta.	isoalantolactone	0-3	interleukin 1 beta	Mus musculus	133-141
30008432-6	2018	Furthermore, MMA and NH4Cl increased the levels of 2",7"-dichlorofluorescein-diacetate (DCF), TNF-alpha, IL-1beta in the cortex, hippocampus and striatum of mice.	methyl malonate	13-16	interleukin 1 beta	Mus musculus	105-113
30071186-7	2018	RESULTS: We found that Dex exerted a potent anti-inflammatory effect by reducing the expression of M1 marker genes such as tumor necrosis factor alpha (P &lt; 0.05), interleukin-1beta (IL-1beta) (P &lt; 0.001) and IL-6 (P &lt; 0.001).	Dexmedetomidine	23-26	interleukin 1 beta	Mus musculus	166-183
30071186-7	2018	RESULTS: We found that Dex exerted a potent anti-inflammatory effect by reducing the expression of M1 marker genes such as tumor necrosis factor alpha (P &lt; 0.05), interleukin-1beta (IL-1beta) (P &lt; 0.001) and IL-6 (P &lt; 0.001).	Dexmedetomidine	23-26	interleukin 1 beta	Mus musculus	185-193
30223923-8	2018	The results showed that TFA significantly inhibited TNF-alpha, IL-1beta, IL-6, iNOS and COX-2 mRNA levels and increased IL-10 mRNA level in LPS-stimulated RAW 264.7 cells in a dose-dependent manner.	Trifluoroacetic Acid	24-27	interleukin 1 beta	Mus musculus	63-71
29885354-5	2018	In vivo results revealed that TCDD further enhanced LPS-increased testis apoptotic cells and concentrations of testicular proinflammatory cytokines (IL1beta, IL18, and IL12) (p &lt; 0.05).	Polychlorinated Dibenzodioxins	30-34	interleukin 1 beta	Mus musculus	149-156
30008432-6	2018	Furthermore, MMA and NH4Cl increased the levels of 2",7"-dichlorofluorescein-diacetate (DCF), TNF-alpha, IL-1beta in the cortex, hippocampus and striatum of mice.	Ammonium Chloride	21-26	interleukin 1 beta	Mus musculus	105-113
30319390-4	2018	We found that ALWPs (500 mg/ml) inhibited lipopolysaccharide (LPS)-induced proinflammatory cytokine IL-1beta mRNA levels in BV2 microglial cells but not primary astrocytes.	alwps	14-19	interleukin 1 beta	Mus musculus	100-108
29929357-8	2018	Moreover, dBV acupoint treatment effectively inhibited the production of interleukin 1 beta, but not tumor necrosis factor alpha in the pleural exudate.	Buformin	10-13	interleukin 1 beta	Mus musculus	73-91
30248132-7	2018	Especially, a flavonoid baicalein significantly inhibited ATP-induced inflammation, including interleukin-1beta secretion, through inhibition of the ATP/P2X7R signaling.	Flavonoids	14-23	interleukin 1 beta	Mus musculus	94-111
30319413-17	2018	Furthermore, budlein A also reduced the IL-1beta maturation, possibly by targeting inflammasome assembly in macrophages.	budlein A	13-22	interleukin 1 beta	Mus musculus	40-48
30250027-11	2018	In addition, silencing Kcnq1ot1 promoted gasdermin D cleavage and the secretion of IL-1beta, thus repressing the TGF-beta1/smads pathway in high glucose-treated cardiac fibroblasts through miR-214-3p and caspase-1.	Glucose	145-152	interleukin 1 beta	Mus musculus	83-91
30248132-7	2018	Especially, a flavonoid baicalein significantly inhibited ATP-induced inflammation, including interleukin-1beta secretion, through inhibition of the ATP/P2X7R signaling.	Adenosine Triphosphate	58-61	interleukin 1 beta	Mus musculus	94-111
30160278-5	2018	Allicin inhibited interleukin-1beta (IL-1beta) induced overproduction of nitric oxide, inducible nitric oxide synthase, prostaglandin E2, and cyclooxygenase-2, as well as pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 in chondrocytes in a dose-dependent manner.	allicin	0-7	interleukin 1 beta	Mus musculus	18-35
30242286-2	2018	We have previously shown that LGI in diabetic mice depends on systemic circulation of leukotriene (LTB4) which potentiates the toll-like/IL1beta receptors response in macrophages.	Leukotrienes	86-97	interleukin 1 beta	Mus musculus	137-144
30160278-5	2018	Allicin inhibited interleukin-1beta (IL-1beta) induced overproduction of nitric oxide, inducible nitric oxide synthase, prostaglandin E2, and cyclooxygenase-2, as well as pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 in chondrocytes in a dose-dependent manner.	allicin	0-7	interleukin 1 beta	Mus musculus	37-45
30231870-14	2018	Moreover, ibrutinib-injected wild-type mice exhibited significantly reduced microglial/astrocyte activation and COX-2 and IL-1beta proinflammatory cytokine levels.	ibrutinib	10-19	interleukin 1 beta	Mus musculus	122-130
30160278-5	2018	Allicin inhibited interleukin-1beta (IL-1beta) induced overproduction of nitric oxide, inducible nitric oxide synthase, prostaglandin E2, and cyclooxygenase-2, as well as pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 in chondrocytes in a dose-dependent manner.	Nitric Oxide	73-85	interleukin 1 beta	Mus musculus	18-35
30160278-5	2018	Allicin inhibited interleukin-1beta (IL-1beta) induced overproduction of nitric oxide, inducible nitric oxide synthase, prostaglandin E2, and cyclooxygenase-2, as well as pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 in chondrocytes in a dose-dependent manner.	Nitric Oxide	73-85	interleukin 1 beta	Mus musculus	37-45
30160278-5	2018	Allicin inhibited interleukin-1beta (IL-1beta) induced overproduction of nitric oxide, inducible nitric oxide synthase, prostaglandin E2, and cyclooxygenase-2, as well as pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 in chondrocytes in a dose-dependent manner.	Dinoprostone	120-136	interleukin 1 beta	Mus musculus	18-35
30160278-5	2018	Allicin inhibited interleukin-1beta (IL-1beta) induced overproduction of nitric oxide, inducible nitric oxide synthase, prostaglandin E2, and cyclooxygenase-2, as well as pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 in chondrocytes in a dose-dependent manner.	Dinoprostone	120-136	interleukin 1 beta	Mus musculus	37-45
30160278-7	2018	Furthermore, allicin dramatically suppressed IL-1beta-stimulated PI3K/Akt/NF-kappaB activation in chondrocytes.	allicin	13-20	interleukin 1 beta	Mus musculus	45-53
30160281-8	2018	The caspase-1 (p10) and interleukin (IL)-1beta (p17) protein expressions in the liver were suppressed by both FCE and FCE oil.	FCE	110-113	interleukin 1 beta	Mus musculus	24-46
30160281-8	2018	The caspase-1 (p10) and interleukin (IL)-1beta (p17) protein expressions in the liver were suppressed by both FCE and FCE oil.	fce oil	118-125	interleukin 1 beta	Mus musculus	24-46
30009814-5	2018	The possible action mechanism of PAC was evaluated using naloxone, L-NAME, glibenclamide and atropine in tail flick test and by Cholinesterase activity assay and production of TNF-alpha and IL-1beta.	piperic acid	33-36	interleukin 1 beta	Mus musculus	190-198
30279646-3	2018	We investigated whether the DMNT inhibitor, zebularine, would alter sickness behavior, DNA methylation of the Il-1beta promoter and expression of inflammatory genes in hippocampus and microglia.	pyrimidin-2-one beta-ribofuranoside	44-54	interleukin 1 beta	Mus musculus	110-118
30279646-6	2018	Bisulfite pyrosequencing revealed that ICV zebularine led to decreased DNA methylation of two CpG sites near the Il-1beta proximal promoter alone or in combination with LPS.	hydrogen sulfite	0-9	interleukin 1 beta	Mus musculus	113-121
30208590-7	2018	Post AD-Fish oil animals demonstrated a significant reduction of IL-6, C-X-C motif chemokine 9 (CXCL9), and IL-1beta compared to Post AD-CTL animals.	Oils	13-16	interleukin 1 beta	Mus musculus	108-116
30237706-7	2018	Results: The nucleosides inhibited inflammatory mediator expression of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, and nitric oxide in both the CSE-stimulated RAW264.7 macrophages and mice.	Nucleosides	13-24	interleukin 1 beta	Mus musculus	115-132
29649477-4	2018	Moreover, distinct proinflammatory cytokines (e.g. IL-1beta, IL-8, ICAM-1 and TNF-alpha) could significantly stimulate the expression levels of the rate-limiting enzymes of catecholamine production in prostate ICCs.	Catecholamines	173-186	interleukin 1 beta	Mus musculus	51-59
30327715-7	2018	In addition, heightened inflammatory responses, demonstrated by the increased expression of proinflammatory factors (TNF-alpha, IL-1beta, and IL-6), in hippocampal and prefrontal cortex tissues of CRS mice were inhibited by THSG administration.	3-cresol	197-200	interleukin 1 beta	Mus musculus	128-136
30327715-7	2018	In addition, heightened inflammatory responses, demonstrated by the increased expression of proinflammatory factors (TNF-alpha, IL-1beta, and IL-6), in hippocampal and prefrontal cortex tissues of CRS mice were inhibited by THSG administration.	thsg	224-228	interleukin 1 beta	Mus musculus	128-136
30228306-7	2018	Also, 15d-PGJ2-loaded NC decreased the maturation of IL-1beta in LPS-primed BMDM triggered by MSU.	15-deoxy-delta(12,14)-prostaglandin J2	6-14	interleukin 1 beta	Mus musculus	53-61
30228306-10	2018	Therefore, we demonstrated that 15d-PGJ2-loaded NC present analgesic and anti-inflammatory properties in a PPAR-gamma-dependent manner inhibiting IL-1beta release and NF-kappaB activation in GA.	15-deoxy-delta(12,14)-prostaglandin J2	32-40	interleukin 1 beta	Mus musculus	146-154
30017640-10	2018	Naringenin also significantly decreased elevated pro-inflammatory cytokines like IL-1beta, IL-6, TNF-alpha and NF-kbeta levels.	naringenin	0-10	interleukin 1 beta	Mus musculus	81-89
30208590-6	2018	RESULTS: Adenine mice exhibited significantly higher mean serum urea, creatinine, and renal expression of the pro-inflammatory markers Interleukin-6 (IL-6), C-X-C motif chemokine 10 (CXCL10), and Interleukin-1beta (IL-1beta), in addition to prominent renal fibrosis and reduced renal Klotho gene expression compared to the control.	Adenine	9-16	interleukin 1 beta	Mus musculus	196-213
30208590-6	2018	RESULTS: Adenine mice exhibited significantly higher mean serum urea, creatinine, and renal expression of the pro-inflammatory markers Interleukin-6 (IL-6), C-X-C motif chemokine 10 (CXCL10), and Interleukin-1beta (IL-1beta), in addition to prominent renal fibrosis and reduced renal Klotho gene expression compared to the control.	Adenine	9-16	interleukin 1 beta	Mus musculus	215-223
30055802-4	2018	Our results here show that DHM potently inhibited caerulin-induced expression and productions of multiple pro-inflammatory cytokines (IL-1beta, TNF-alpha and IL-17) in murine bone marrow-derived macrophages (BMDMs).	dihydromyricetin	27-30	interleukin 1 beta	Mus musculus	134-142
30201855-10	2018	In vitro studies using lipopolysaccharide-activated RAW264.7 cells showed that BPNPs inhibited cyclooxygenase-2, inducible nitric oxide (NO) synthase expression, and the production of proinflammatory mediators, including NO, tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta through suppressing the Toll-like receptor 4/NF-kappaB signaling pathway.	bpnps	79-84	interleukin 1 beta	Mus musculus	273-290
30189890-5	2018	RESULTS: Oral administration of arhalofenate (250 mg/kg) blunted total leukocyte ingress, neutrophil influx, and air pouch fluid interleukin (IL)-1beta, IL-6, and CXCL1 in response to MSU crystal injection (p &lt; 0.05 for each).	arhalofenate	32-44	interleukin 1 beta	Mus musculus	129-151
30189890-6	2018	Arhalofenate acid (100 muM) attenuated MSU crystal-induced IL-1beta production in BMDMs via inhibition of NLRP3 inflammasome activation.	arhalofenate acid	0-17	interleukin 1 beta	Mus musculus	59-67
29963998-0	2018	Therapeutic potential of dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice by targeting IL-1beta and IL-18.	dinitrobenzenesulfonic acid	25-53	interleukin 1 beta	Mus musculus	98-106
30233585-15	2018	Calcium content-matched primary CPP caused twice more IL-1beta secretion than did secondary CPP, which was associated with increased calcium-dependent inflammasome activation, suggesting that intracellular CPP dissolution and calcium overload may cause this inflammation.	Calcium	0-7	interleukin 1 beta	Mus musculus	54-62
30233585-15	2018	Calcium content-matched primary CPP caused twice more IL-1beta secretion than did secondary CPP, which was associated with increased calcium-dependent inflammasome activation, suggesting that intracellular CPP dissolution and calcium overload may cause this inflammation.	Calcium	133-140	interleukin 1 beta	Mus musculus	54-62
29736671-8	2018	However, the levels of IL-1beta, TNF-alpha and RANTES in the FFA-zanamivir-clarithromycin triple combination group were significantly lower than those in the zanamivir-clarithromycin double combination group, zanamivir monotherapy group, or solvent group on day 2 postinfection.	Flufenamic Acid	61-64	interleukin 1 beta	Mus musculus	23-31
30254716-7	2018	Furthermore, melatonin decreased NLRP3 inflammasome activation and the consequent IL-1beta secretion within atherosclerotic lesions.	Melatonin	13-22	interleukin 1 beta	Mus musculus	82-90
29580805-1	2018	Succinate is known to act as an inflammatory signal in classically activated macrophages through stabilization of HIF-1alpha leading to IL-1beta production.	Succinic Acid	0-9	interleukin 1 beta	Mus musculus	136-144
29963998-0	2018	Therapeutic potential of dinitrobenzene sulfonic acid (DNBS)-induced colitis in mice by targeting IL-1beta and IL-18.	dinitrobenzenesulfonic acid	55-59	interleukin 1 beta	Mus musculus	98-106
29963998-6	2018	The results indicated that single knockout (KO) mice of IL-1beta or IL-18, and double KO mice of both IL-1beta and IL-18 were hyporesponsive to DNBS-induced colitis compared to wild type (WT) mice, in which double KO were less sensitive than single KO mice.	dinitrobenzenesulfonic acid	144-148	interleukin 1 beta	Mus musculus	102-110
29906750-14	2018	SDS-induced increase in brain level of IL-1beta (236.5 +- 6.92 rhog/mL) was significantly (p &lt; 0.05) reduced by naringenin (219.90 +- 15.25 rhog/mL).	sds	0-3	interleukin 1 beta	Mus musculus	39-47
29890468-8	2018	Calycosin treatment reversed the increased serum levels of amylase and lipase, alleviated the pathological damage in the pancreas, and decreased the levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta in mice with AP.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	interleukin 1 beta	Mus musculus	218-226
29859240-4	2018	We reported here that H2S attenuated hydrogen peroxide (H2O2)-induced NLRP3 inflammasome activation, which led to caspase-1 activation and IL-1beta production in macrophages.	Hydrogen Peroxide	37-54	interleukin 1 beta	Mus musculus	139-147
29859240-4	2018	We reported here that H2S attenuated hydrogen peroxide (H2O2)-induced NLRP3 inflammasome activation, which led to caspase-1 activation and IL-1beta production in macrophages.	Hydrogen Peroxide	56-60	interleukin 1 beta	Mus musculus	139-147
29966735-8	2018	OLA also influenced the expression of mRNA encoding pro-inflammatory cytokines (IL-1beta and IL-6) and some lipogenic genes (PPARalpha, SREBP1, FAS, ChREBP, and G6Pase) in liver and adipose tissue.	Oleanolic Acid	0-3	interleukin 1 beta	Mus musculus	80-88
29906750-14	2018	SDS-induced increase in brain level of IL-1beta (236.5 +- 6.92 rhog/mL) was significantly (p &lt; 0.05) reduced by naringenin (219.90 +- 15.25 rhog/mL).	naringenin	115-125	interleukin 1 beta	Mus musculus	39-47
29721581-11	2018	Glycyrrhizin was found to significantly decrease the secretion of inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6).	Glycyrrhizic Acid	0-12	interleukin 1 beta	Mus musculus	101-109
29990699-11	2018	IFO 400 mg/kg significantly increased visceral hyperalgesia, bladder edema, hemorrhage, vascular permeability, MPO, IL-1beta and IL-6 tissue levels, and COX-2 immunostaining and expression versus the saline group (P &lt; 0.05).	Ifosfamide	0-3	interleukin 1 beta	Mus musculus	116-124
29775715-5	2018	Polysaccharide molecules obtained using Cellic CTec2 enzyme induced RAW264.7 murine macrophage cells to release considerable amount of inflammatory mediators including nitric oxide, IL-1beta, TNF-alpha, IL-6 and IL-10.	Polysaccharides	0-14	interleukin 1 beta	Mus musculus	182-190
30015238-0	2018	Sauchinone inhibits IL-1beta induced catabolism and hypertrophy in mouse chondrocytes to attenuate osteoarthritis via Nrf2/HO-1 and NF-kappaB pathways.	sauchinone	0-10	interleukin 1 beta	Mus musculus	20-28
30015238-7	2018	Col X, vascular endothelial growth factor-A (VEGF)-A, and Runx2, major markers of hypertrophic chondrocytes, were markedly elevated following IL-1beta stimulation, and were reduced by SAU treatment while having the opposite effect on Col II.	sauchinone	184-187	interleukin 1 beta	Mus musculus	142-150
28983699-7	2018	Teriparatide significantly inhibited the expression of IL-1beta, IL-6 and TNF-alpha in OVX mice in the early phase of the treatment, while the TRAP5b level in OVX mice was not significantly affected.	Teriparatide	0-12	interleukin 1 beta	Mus musculus	55-63
30246698-10	2018	Particulate alginate induced the most potent inflammatory reaction as determined by the production of cytokines, such as, IL-1beta, IL-8, TNF-alpha and IFN-gamma.	Alginates	12-20	interleukin 1 beta	Mus musculus	122-130
28983699-8	2018	We demonstrated that the teriparatide-induced rapid improvement effect on pain-like behavior in OVX mice was associated with the downregulation of inflammatory cytokine expression, including IL-1beta, IL-6 and TNF-alpha.	Teriparatide	25-37	interleukin 1 beta	Mus musculus	191-199
29248164-8	2018	RESULTS: At 10h after CS injection, serum cytokines IL-6 and IL-1beta in the WT mice were increased by 511- and 43-fold whereas in KO mice, these levels were increased by 166-fold and 22-fold, respectively.	Cesium	22-24	interleukin 1 beta	Mus musculus	61-69
29374854-9	2018	RESULTS: PA elevated not only phosphorylation of JNK, IRS1 serines, and IKKalpha/beta, but also the expression of IL-6, TNFalpha and IL-1beta in C2C12-GLUT4myc cells.	Palmitic Acid	9-11	interleukin 1 beta	Mus musculus	133-141
29248164-9	2018	Lung IL-1beta in the WT mice increased by 7-fold after CS injection whereas only a 4-fold increase was seen in the KO mice.	Cesium	55-57	interleukin 1 beta	Mus musculus	5-13
29876982-5	2018	Casticin decreased reactive oxygen species level and chemocytokines (IL-1beta, IL-6, TNF-alpha) productions in colon tissue.	casticin	0-8	interleukin 1 beta	Mus musculus	69-77
30146016-12	2018	Finally, icariin suppressed NLRP3 inflammasome activation and IL-1beta production in MRL/lpr mice.	icariin	9-16	interleukin 1 beta	Mus musculus	62-70
29971769-5	2018	KEY FINDINGS: Methylsulfonylmethane significantly ameliorated pancreas and lung histopathological changes, decreased serum amylase, MPO activity and inhibited caerulein-induced IL-1beta expression.	dimethyl sulfone	14-35	interleukin 1 beta	Mus musculus	177-185
29971769-5	2018	KEY FINDINGS: Methylsulfonylmethane significantly ameliorated pancreas and lung histopathological changes, decreased serum amylase, MPO activity and inhibited caerulein-induced IL-1beta expression.	Ceruletide	159-168	interleukin 1 beta	Mus musculus	177-185
29322353-8	2018	Our observation from the present research work reveals that Quercetin suppressed the production of proinflammatory cytokines at different levels, such as TNF-alpha and IL-1beta, and inhibits the activation of I-kappaB phosphorylation, whereas the total content was not affected.	Quercetin	60-69	interleukin 1 beta	Mus musculus	168-176
30176521-7	2018	However, S. gordonii wild-type and DeltaltaS potently induced the expression of proinflammatory cytokines including TNF-alpha, IL-8, and IL-1beta at the mRNA and protein levels, while Deltalgt did not have these effects.	deltaltas	35-44	interleukin 1 beta	Mus musculus	137-145
30200495-3	2018	GRh2 reduced LPS-induced proinflammatory mediator nitric oxide (NO), tumor necrosis factor-alpha, interleukin (IL)-1beta, and anti-inflammatory cytokines (IL-4, IL-6, and IL-10) production in lung tissues.	ginsenoside Rh2	0-4	interleukin 1 beta	Mus musculus	98-120
29535050-5	2018	TRPA1 inhibitors (HC-030031 and A-967079) and a CGRP inhibitor (MK-8825) reduced skin edema, pro-inflammatory cytokines (IL-1beta, CXCL1/KC), MMP-9, a protease implicated in skin damage, and improved histopathological outcomes.	MK-8825	64-71	interleukin 1 beta	Mus musculus	121-129
28991049-5	2018	Moreover, stearoyl LPC treatment conferred significant protection against lethal endotoxemia and significantly reduced the release of IL-1alpha and IL-1beta.	stearoyl alpha-lysolecithin	10-22	interleukin 1 beta	Mus musculus	148-156
30078232-9	2018	The Rev-erbalpha knockout mice showed prolonged microglial activation in the SN along with the overproduction of interleukin 1beta, a pro-inflammatory cytokine, in response to 6-OHDA.	Oxidopamine	176-182	interleukin 1 beta	Mus musculus	113-130
30003915-7	2018	Additionally, carrageenan-induced cyclooxygenase-2 (COX-2) and pro-inflammatory cytokines (TNFalpha and IL-1beta) were also significantly down-regulated by saPLIgamma in a dose-dependent manner.	Carrageenan	14-25	interleukin 1 beta	Mus musculus	104-112
30224927-8	2018	Also, BSYZ inhibits NLRP3 activation and interleukin-1beta production of the 1-methyl-4-phenyl-pyridinium (MPP+) stimulated BV-2 microglia cells.	1-Methyl-4-phenylpyridinium	77-105	interleukin 1 beta	Mus musculus	41-58
29588315-2	2018	IL-1beta and IL-18 are produced via the NLRP3 inflammasome in myeloid cells in response to cholesterol accumulation, but mechanisms linking NLRP3 inflammasome activation to atherogenesis are unclear.	Cholesterol	91-102	interleukin 1 beta	Mus musculus	0-8
30214410-6	2018	In addition, qPCR results showed that magnoflorine dose-dependently decreased the expression of pro-inflammatory cytokines TNF-alpha, IL-1beta, and IL-6.	magnoflorine	38-50	interleukin 1 beta	Mus musculus	134-142
30214444-0	2018	ATF3 Stimulates IL-17A by Regulating Intracellular Ca2+/ROS-Dependent IL-1beta Activation During Streptococcus pneumoniae Infection.	ros	56-59	interleukin 1 beta	Mus musculus	70-78
30214444-7	2018	Moreover, mitochondrial IL-1beta production by bone marrow-derived macrophages was significantly reduced in ATF3 KO mice as a result of the disruption of cellular ROS and Ca2+ homeostasis.	ros	163-166	interleukin 1 beta	Mus musculus	24-32
30224927-8	2018	Also, BSYZ inhibits NLRP3 activation and interleukin-1beta production of the 1-methyl-4-phenyl-pyridinium (MPP+) stimulated BV-2 microglia cells.	mangion-purified polysaccharide (Candida albicans)	107-111	interleukin 1 beta	Mus musculus	41-58
30134985-12	2018	RESULTS: IL-6 and IL-1beta levels were decreased by 250 mug/ml cefazolin in the LPS-stimulated C8-B4 cells.	Cefazolin	63-72	interleukin 1 beta	Mus musculus	18-26
29976759-6	2018	Inhibiting reactive oxygen species (ROS) by N-acetyl-l-cysteine or mito-TEMPO and inhibiting activation of cathepsin B by CA-074 blocked SAA-mediated inflammasome activation and IL-1beta secretion.	N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline	122-128	interleukin 1 beta	Mus musculus	178-186
29976759-7	2018	Moreover, inhibiting cellular potassium efflux with glyburide or increasing extracellular potassium also significantly reduced SAA-mediated IL-1beta secretion.	Potassium	30-39	interleukin 1 beta	Mus musculus	140-148
29976759-7	2018	Moreover, inhibiting cellular potassium efflux with glyburide or increasing extracellular potassium also significantly reduced SAA-mediated IL-1beta secretion.	Glyburide	52-61	interleukin 1 beta	Mus musculus	140-148
29976759-7	2018	Moreover, inhibiting cellular potassium efflux with glyburide or increasing extracellular potassium also significantly reduced SAA-mediated IL-1beta secretion.	Potassium	90-99	interleukin 1 beta	Mus musculus	140-148
30190704-4	2018	Moreover, the administration of 0.5% l-serine decreased the concentrations of leptin, malondialdehyde, interleukin-1beta, and interleukin-6, while it increased those of superoxide dismutase and glutathione, in both the serum and hypothalamus.	Serine	37-45	interleukin 1 beta	Mus musculus	103-120
30138321-0	2018	Effects of metal ions on caspase-1 activation and interleukin-1beta release in murine bone marrow-derived macrophages.	Metals	11-16	interleukin 1 beta	Mus musculus	50-67
30138321-2	2018	Studies with macrophages have shown that cobalt, chromium, and nickel ions can activate the NLRP3 inflammasome, a multiprotein complex responsible for the activation of caspase-1 (a proteolytic enzyme converting pro-interleukin [IL]-1beta to mature IL-1beta).	Cobalt	41-47	interleukin 1 beta	Mus musculus	249-257
30138321-2	2018	Studies with macrophages have shown that cobalt, chromium, and nickel ions can activate the NLRP3 inflammasome, a multiprotein complex responsible for the activation of caspase-1 (a proteolytic enzyme converting pro-interleukin [IL]-1beta to mature IL-1beta).	Chromium	49-57	interleukin 1 beta	Mus musculus	249-257
30138321-2	2018	Studies with macrophages have shown that cobalt, chromium, and nickel ions can activate the NLRP3 inflammasome, a multiprotein complex responsible for the activation of caspase-1 (a proteolytic enzyme converting pro-interleukin [IL]-1beta to mature IL-1beta).	Nickel	63-69	interleukin 1 beta	Mus musculus	249-257
30138321-5	2018	caspase-1 activation and IL-1beta release induced by metal ions are oxidative stress-dependent; and 2.	Metals	53-58	interleukin 1 beta	Mus musculus	25-33
30138321-6	2018	IL-1beta release induced by metal ions is NF-kappaB signaling pathway-dependent.	Metals	28-33	interleukin 1 beta	Mus musculus	0-8
30138321-10	2018	When L-AA (2 mM) was present with Cr3+, the caspase-1 p20 subunit was undetectable and IL-1beta release decreased down to the level of the negative control, thereby demonstrating that caspase-1 activation and IL-1beta release induced by Cr3+ was oxidative stress-dependent.	Ascorbic Acid	5-9	interleukin 1 beta	Mus musculus	87-95
30138321-10	2018	When L-AA (2 mM) was present with Cr3+, the caspase-1 p20 subunit was undetectable and IL-1beta release decreased down to the level of the negative control, thereby demonstrating that caspase-1 activation and IL-1beta release induced by Cr3+ was oxidative stress-dependent.	Ascorbic Acid	5-9	interleukin 1 beta	Mus musculus	209-217
30138321-12	2018	In the presence of Ni2+, the addition of L-AA (2 mM) also decreased IL-1beta release, below the level of the negative control, suggesting that IL-1beta release induced by Ni2+ was also oxidative stress-dependent.	Nickel(2+)	19-23	interleukin 1 beta	Mus musculus	143-151
30134985-17	2018	Cefazolin treatment for 5 days in mice without surgery induced colon dysbiosis and increased IL-6 and IL-1beta in the colon and IL-1beta in the cerebral cortex.	Cefazolin	0-9	interleukin 1 beta	Mus musculus	102-110
30138321-12	2018	In the presence of Ni2+, the addition of L-AA (2 mM) also decreased IL-1beta release, below the level of the negative control, suggesting that IL-1beta release induced by Ni2+ was also oxidative stress-dependent.	Nickel(2+)	171-175	interleukin 1 beta	Mus musculus	68-76
30138321-12	2018	In the presence of Ni2+, the addition of L-AA (2 mM) also decreased IL-1beta release, below the level of the negative control, suggesting that IL-1beta release induced by Ni2+ was also oxidative stress-dependent.	Nickel(2+)	171-175	interleukin 1 beta	Mus musculus	143-151
30134985-17	2018	Cefazolin treatment for 5 days in mice without surgery induced colon dysbiosis and increased IL-6 and IL-1beta in the colon and IL-1beta in the cerebral cortex.	Cefazolin	0-9	interleukin 1 beta	Mus musculus	128-136
29856968-6	2018	In an AR animal model, ABT-737 significantly diminished clinical symptoms of AR and the levels of AR biomarkers, specifically IgE, histamine, hypoxia-inducible factor-1alpha, VEGF, TSLP, IL-1beta, IL-4, IL-5, IL-6, IL-13, TNF-alpha, intercellular adhesion molecule-1, and macrophage inflammatory protein-2.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	23-26	interleukin 1 beta	Mus musculus	187-195
30140293-2	2018	Diacerein is an interleukin-1beta (IL-1beta) inhibitor used for osteoarthritis treatment by exerting anti-inflammatory effects.	diacerein	0-9	interleukin 1 beta	Mus musculus	16-33
30140293-2	2018	Diacerein is an interleukin-1beta (IL-1beta) inhibitor used for osteoarthritis treatment by exerting anti-inflammatory effects.	diacerein	0-9	interleukin 1 beta	Mus musculus	35-43
30140293-8	2018	Moreover, diacerein inhibited LPS-induced increase of inflammatory cytokines, such as IL-1beta, tumor necrosis factor-alpha, monocyte chemoattractant protein-1 and nitric oxide synthase 2.	diacerein	10-19	interleukin 1 beta	Mus musculus	86-94
30126430-9	2018	GSK872 significantly suppressed the activation of necroptosis and NLRP3 activation with reduction of IL-1beta and IL-18 production and inflammatory cells infiltration, resulting in a significant amelioration of lung injury.	GSK872	0-6	interleukin 1 beta	Mus musculus	101-109
30110942-7	2018	AS-IV was found to reverse the APAP-induced increased amounts of pro-inflammatory cytokines, including interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha).	Acetaminophen	31-35	interleukin 1 beta	Mus musculus	103-120
30107806-9	2018	In addition, corylin inhibited the expression of iNOS and COX-2, attenuated the phosphorylation of ERK, JNK and p38, decreased the expression of NLRP3 and ASC, and repressed the activation of caspase-1 and IL-1beta by LPS-activated BV2 cells.	corylin	13-20	interleukin 1 beta	Mus musculus	206-214
30210674-5	2018	The levels of tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6, as well as total protein and Evans blue concentrations, were all significantly reduced in bronchoalveolar lavage fluid from mice treated with rivaroxaban.	Rivaroxaban	224-235	interleukin 1 beta	Mus musculus	43-61
30110942-7	2018	AS-IV was found to reverse the APAP-induced increased amounts of pro-inflammatory cytokines, including interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha).	Acetaminophen	31-35	interleukin 1 beta	Mus musculus	122-130
30103680-11	2018	Liver histopathological lesions, impaired liver function, enhanced proteins and mRNA levels of TNF-alpha, IFN-gamma, IL-1beta, IL-17A, TLR4, TRAF6 and NF-kappaB were observed after DSS administration.	Dextran Sulfate	181-184	interleukin 1 beta	Mus musculus	117-125
29775893-9	2018	However, puerarin pre-treatment attenuated the vascular endothelial injury and reduced the levels of TNF-alpha, IL-1beta, MCP-1, IL-8, ICAM-1, TM and PAI-1 in cell supernatants of LPS-challenged HUVECs.	puerarin	9-17	interleukin 1 beta	Mus musculus	112-120
29740932-4	2018	PPARgamma antagonist T0070907 increased the expression of M2 markers, including CD206, IL-4, IGF-1, TGF-beta1, TGF-beta2, TGF-beta3, G-CSF, and GM-CSF, and reduced the expression of M1 markers, such as CD86, Cox-2, iNOS, IL-1beta, IL-6, TNF-alpha, IFN-gamma, and CCL2, thereby inhibiting NFkappaB-IKKbeta activation.	T 0070907	21-29	interleukin 1 beta	Mus musculus	221-229
29802129-6	2018	The accumulation of EDPs induces hepatic lipogenesis (i.e., SREBP1c and ACC), inflammation (i.e., Kupffer cells, IL-1beta, and TGF-beta), and fibrosis (collagen and elastin expression).	edps	20-24	interleukin 1 beta	Mus musculus	113-121
29746822-5	2018	Tabersonine also inhibited LPS-mediated neutrophil infiltration, elevation of MPO activity and the production of TNF-alpha, IL-6 and IL-1beta.	tabersonine	0-11	interleukin 1 beta	Mus musculus	133-141
29102800-6	2018	In mice, acute binge ethanol induced both HMGB1 and IL-1beta in the brain and plasma.	Ethanol	21-28	interleukin 1 beta	Mus musculus	52-60
29102800-7	2018	HMGB1 and IL-1beta complexes were found only in mouse brain, with confocal microscopy revealing an ethanol-induced HMGB1 and IL-1beta cytoplasmic co-localization.	Ethanol	99-106	interleukin 1 beta	Mus musculus	10-18
29102800-7	2018	HMGB1 and IL-1beta complexes were found only in mouse brain, with confocal microscopy revealing an ethanol-induced HMGB1 and IL-1beta cytoplasmic co-localization.	Ethanol	99-106	interleukin 1 beta	Mus musculus	125-133
29102800-9	2018	Studies in hippocampal brain slice culture found ethanol increased HMGB1/IL-1beta complexes in the media.	Ethanol	49-56	interleukin 1 beta	Mus musculus	73-81
29102800-11	2018	Immunogenic HMGB1/IL-1beta complexes represent a novel target for immune modulatory therapy in alcohol use disorders, and should be investigated in other psychiatric diseases that involve a neuroimmune component.	Alcohols	95-102	interleukin 1 beta	Mus musculus	18-26
29654431-5	2018	The results showed that SSa significantly inhibited CS-induced inflammatory cell infiltration, NO, TNF-alpha, and IL-1beta production in BALF.	Cesium	52-54	interleukin 1 beta	Mus musculus	114-122
29656318-6	2018	Of the eight imidazoles tested, methyl 1-allyl-2-(4-fluorophenyl)-5-phenyl-1H-imidazole-4-acetate (8) inhibited nitric oxide metabolites and pro-inflammatory cytokine (TNF-alpha, IL-6, and IL-1beta) secretion in J774 macrophages stimulated with LPS.	Imidazoles	13-23	interleukin 1 beta	Mus musculus	189-197
29616391-6	2018	Moreover, these sesquiterpenes also attenuated the mRNA expression of pro-inflammatory cytokines including interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) in LPS-induced BV2 microglial cells.	Sesquiterpenes	16-30	interleukin 1 beta	Mus musculus	107-124
29616391-6	2018	Moreover, these sesquiterpenes also attenuated the mRNA expression of pro-inflammatory cytokines including interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) in LPS-induced BV2 microglial cells.	Sesquiterpenes	16-30	interleukin 1 beta	Mus musculus	126-134
29633103-9	2018	Moreover, vinpocetine reduced NF-kappaB activation and thereby NF-kappaB-dependent pro-inflammatory cytokines IL-1beta, TNF-alpha, and IL-33 in the colon.	vinpocetine	10-21	interleukin 1 beta	Mus musculus	110-118
29656318-6	2018	Of the eight imidazoles tested, methyl 1-allyl-2-(4-fluorophenyl)-5-phenyl-1H-imidazole-4-acetate (8) inhibited nitric oxide metabolites and pro-inflammatory cytokine (TNF-alpha, IL-6, and IL-1beta) secretion in J774 macrophages stimulated with LPS.	methyl 1-allyl-2-(4-fluorophenyl)-5-phenyl-1h-imidazole-4-acetate	32-97	interleukin 1 beta	Mus musculus	189-197
29656318-6	2018	Of the eight imidazoles tested, methyl 1-allyl-2-(4-fluorophenyl)-5-phenyl-1H-imidazole-4-acetate (8) inhibited nitric oxide metabolites and pro-inflammatory cytokine (TNF-alpha, IL-6, and IL-1beta) secretion in J774 macrophages stimulated with LPS.	Nitric Oxide	112-124	interleukin 1 beta	Mus musculus	189-197
31949780-10	2018	We found that simvastatin treatment could significantly inhibit inflammation by modulating the expression of mediators, such as IL-1beta, TNF-alpha and IL-6, whose expression were increased remarkably in the activated RAW264.7 cells.	Simvastatin	14-25	interleukin 1 beta	Mus musculus	128-136
29879659-6	2018	qRT-PCR and ELISA experiments suggested that leonurine inhibited the expression levels of TNF-alpha and IL-1beta in uterus tissues and bEECs.	leonurine	45-54	interleukin 1 beta	Mus musculus	104-112
29890414-4	2018	In addition, DGP decreased the production of reactive oxygen species (ROS) and pro-inflammatory cytokines such as interleukin (IL)-6, IL-1beta, and tumor necrosis factor alpha (TNF-alpha).	dgp	13-16	interleukin 1 beta	Mus musculus	134-142
29894720-8	2018	Furthermore, we observed that treatment of THP-1 and AMJ2-C11 cell lines with exogenous PGE2 reduces MIP-1alpha production, while increasing IL-1beta production in cells stimulated by B. jararaca or B. jararacussu venoms.	Dinoprostone	88-92	interleukin 1 beta	Mus musculus	141-149
29108965-7	2018	Indeed, exposure of mouse tracheal epithelial cells to IL-1beta or IL-1alpha resulted in increased glycolytic flux, glucose use, expression of glycolysis genes, and lactate production.	Glucose	116-123	interleukin 1 beta	Mus musculus	55-63
29108965-7	2018	Indeed, exposure of mouse tracheal epithelial cells to IL-1beta or IL-1alpha resulted in increased glycolytic flux, glucose use, expression of glycolysis genes, and lactate production.	Lactic Acid	165-172	interleukin 1 beta	Mus musculus	55-63
29368095-4	2018	Pre-treatment of RAW 264.7 cells with FAD suppressed LPS-stimulated mRNA expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFalpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1beta) and thereby reduced the respective protein levels.	falcarindiol	38-41	interleukin 1 beta	Mus musculus	193-211
29368095-4	2018	Pre-treatment of RAW 264.7 cells with FAD suppressed LPS-stimulated mRNA expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFalpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1beta) and thereby reduced the respective protein levels.	falcarindiol	38-41	interleukin 1 beta	Mus musculus	213-221
30415241-2	2018	In this study, we compared the benefits of an angiotensin-converting enzyme (ACE) inhibitor, enalapril, an angiotensin receptor blocker, losartan and their combination in dextran sodium sulfate (DSS)-induced colitis in mice by assessing the histopathological and macroscopic changes in the colon, and by measuring the expression of the pro-inflammatory interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (Tnf-alpha) genes.	dss	195-198	interleukin 1 beta	Mus musculus	353-370
30415241-2	2018	In this study, we compared the benefits of an angiotensin-converting enzyme (ACE) inhibitor, enalapril, an angiotensin receptor blocker, losartan and their combination in dextran sodium sulfate (DSS)-induced colitis in mice by assessing the histopathological and macroscopic changes in the colon, and by measuring the expression of the pro-inflammatory interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (Tnf-alpha) genes.	dss	195-198	interleukin 1 beta	Mus musculus	372-380
30415241-5	2018	In addition, enalapril downregulated the pro-inflammatory IL-1beta expression whereas losartan treatment resulted in lower macroscopic scores, but the effects of the medications were not synergistic when the drugs were combined.	Enalapril	13-22	interleukin 1 beta	Mus musculus	58-66
29264825-11	2018	In addition, retinal expression of NLRP3, Caspase-1 p20, IL-1beta p17, and ICAM-1 were dramatically increased in vehicle-treated diabetic mice, which were abolished by fenofibrate intervention.	Fenofibrate	168-179	interleukin 1 beta	Mus musculus	57-65
30049950-5	2018	The results showed that OEO (2.5-10 mug/mL) inhibited the expression and secretion of interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in RAW264.7 cells treated with LPS (1 mug/mL).	oeo	24-27	interleukin 1 beta	Mus musculus	86-104
30060484-5	2018	Treatment with DA inhibited the activation of MAP kinases and the translocation of NFkappaB, and decreased the expression and exogenous secretion of IL-1beta and IL-6.	decursin	15-17	interleukin 1 beta	Mus musculus	149-157
30060484-9	2018	Treatment with DA also inhibited the expression of pro-inflammatory cytokines, such as IL-1beta and IL-6, NOX, and iNOS in Raw 264.7 cells.	decursin	15-17	interleukin 1 beta	Mus musculus	87-95
30049950-5	2018	The results showed that OEO (2.5-10 mug/mL) inhibited the expression and secretion of interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in RAW264.7 cells treated with LPS (1 mug/mL).	oeo	24-27	interleukin 1 beta	Mus musculus	106-114
30049950-7	2018	Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibition in Nox2 protein-silenced cells attenuated the mRNA expression of IL-1beta, IL-6, and TNF-alpha in the LPS-induced RAW264.7 cells.	NADP	0-43	interleukin 1 beta	Mus musculus	136-144
30044427-6	2018	The attenuation of GSH release via block of multidrug resistance-associated protein 1 (MRP1) transport also abrogated the protective effect of IL-1beta.	Glutathione	19-22	interleukin 1 beta	Mus musculus	143-151
30044427-0	2018	Interleukin-1beta Protects Neurons against Oxidant-Induced Injury via the Promotion of Astrocyte Glutathione Production.	Glutathione	97-108	interleukin 1 beta	Mus musculus	0-17
30044427-2	2018	Although IL-1beta contributes to and/or sustains pathophysiological processes in the CNS, we recently demonstrated that IL-1beta can protect cortical astrocytes from oxidant injury in a glutathione (GSH)-dependent manner.	Glutathione	186-197	interleukin 1 beta	Mus musculus	120-128
30044427-2	2018	Although IL-1beta contributes to and/or sustains pathophysiological processes in the CNS, we recently demonstrated that IL-1beta can protect cortical astrocytes from oxidant injury in a glutathione (GSH)-dependent manner.	Glutathione	199-202	interleukin 1 beta	Mus musculus	120-128
29969892-6	2018	Furthermore, compared with no treatment, pretreatment with theanine significantly decreased the release of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha, inhibited the expression of several inflammatory factors (including IL-1beta, TNF-alpha, and IL-6), and increased the IL-10/interferon (IFN)-gamma ratio in the hepatic tissues.	theanine	59-67	interleukin 1 beta	Mus musculus	107-129
29969892-6	2018	Furthermore, compared with no treatment, pretreatment with theanine significantly decreased the release of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha, inhibited the expression of several inflammatory factors (including IL-1beta, TNF-alpha, and IL-6), and increased the IL-10/interferon (IFN)-gamma ratio in the hepatic tissues.	theanine	59-67	interleukin 1 beta	Mus musculus	237-245
30044427-4	2018	Neurons and astrocytes in mixed cultures, but not pure neurons, were significantly protected from the toxicity of t-BOOH following treatment with IL-1beta in association with enhanced GSH production/release.	t-booh	114-120	interleukin 1 beta	Mus musculus	146-154
30044427-8	2018	Overall, our data indicate that IL-1beta protects neurons against oxidant injury and that this likely occurs in a non-cell-autonomous manner that relies on an increase in astrocyte GSH production and release.	Glutathione	181-184	interleukin 1 beta	Mus musculus	32-40
30090104-14	2018	Moreover, decreased expression of pro-inflammatory cytokines including TNF-alpha, IL-6, and IL-1beta and inhibition of NF-kappaB and STAT pathways were found in EAU mice following TCDD treatment.	Polychlorinated Dibenzodioxins	180-184	interleukin 1 beta	Mus musculus	92-100
30037009-6	2018	Calcitriol and its analogs decreased the levels of interleukin (IL)-1beta and IL-10 and increased the level of interferon gamma (IFN-gamma) in the plasma.	Calcitriol	0-10	interleukin 1 beta	Mus musculus	51-73
29986533-7	2018	Furthermore, CBG pre-treatment counteracted not only inflammation, as demonstrated by the reduction of IL-1beta, TNF-alpha, IFN-gamma and PPARgamma protein levels assessed by immunocytochemistry, but also oxidative stress in NSC-34 cells treated with the medium of LPS-stimulated RAW 264.7.	cannabigerol	13-16	interleukin 1 beta	Mus musculus	103-111
30011811-7	2018	We found that Farrerol observably reduced the production of inflammatory mediators including IL-1beta, IL-6, TNF-alpha, COX-2, and iNOS in LPS-induced RAW264.7 cells via suppressing AKT, ERK1/2, JNK1/2, and NF-kappaB p65 phosphorylation.	farrerol	14-22	interleukin 1 beta	Mus musculus	93-101
30030497-7	2018	Furthermore, we demonstrate that Ang II-upregulated expression of IL-6, Tnf-alpha, IL-1beta and Tgf-beta1 is significantly attenuated in the mice treated with AS605240.	5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione	159-167	interleukin 1 beta	Mus musculus	83-91
29668250-6	2018	Furthermore, baicalein significantly inhibited the release of proinflammatory cytokines such as interleukin-6 (IL-6), interleukin-1 beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) in the brain cortex of SAMP8 mice.	baicalein	13-22	interleukin 1 beta	Mus musculus	118-136
29668250-6	2018	Furthermore, baicalein significantly inhibited the release of proinflammatory cytokines such as interleukin-6 (IL-6), interleukin-1 beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) in the brain cortex of SAMP8 mice.	baicalein	13-22	interleukin 1 beta	Mus musculus	138-146
30116260-4	2018	The levels of hepatic necrosis, apoptosis, and autophagy associated with inflammatory cytokines were measured at 2, 8, and 24 h. Results: Fucosterol attenuated serum liver enzyme levels and hepatic necrosis and apoptosis induced by TNF-alpha, IL-6, and IL-1beta.	fucosterol	138-148	interleukin 1 beta	Mus musculus	253-261
30093935-7	2018	We determine that RSV administration inhibited the increased production of TNF-alpha, IL-6, and IL-1beta in LPS-stimulated MH-S cells, which was associated with inhibition of the nuclear factor-kappaB, P38, and ERK signaling pathways.	Resveratrol	18-21	interleukin 1 beta	Mus musculus	96-104
30093945-7	2018	Following celastrol pretreatment, mice showed increased mortality rate and aggravated inflammation evidenced by further enhanced inflammatory markers of IL-6, IL-1beta, TNF-alpha, IL-18, MCP-1, and ICAM-1 in circulation, liver, and kidney after LPS treatment.	celastrol	10-19	interleukin 1 beta	Mus musculus	159-167
29891555-0	2018	Cysteine-Reactive Free ISG15 Generates IL-1beta-Producing CD8alpha+ Dendritic Cells at the Site of Infection.	Cysteine	0-8	interleukin 1 beta	Mus musculus	39-47
29792864-2	2018	In the present study, we found that delavatine A substantially suppressed the LPS-induced pro-inflammatory mediators, nitric oxide (NO), and tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), interleukin-1beta (IL-1beta) in BV-2 microglial cells.	delavatine A	36-48	interleukin 1 beta	Mus musculus	196-213
29792864-2	2018	In the present study, we found that delavatine A substantially suppressed the LPS-induced pro-inflammatory mediators, nitric oxide (NO), and tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), interleukin-1beta (IL-1beta) in BV-2 microglial cells.	delavatine A	36-48	interleukin 1 beta	Mus musculus	215-223
29927623-5	2018	In addition, lactate production has increased in progenitors isolated from injured tendons after treatment with IL-1beta.	Lactic Acid	13-20	interleukin 1 beta	Mus musculus	112-120
30025085-11	2018	Topical application of latanoprost promoted activation of P38-NF-kappaB signaling and production of TNF-alpha and IL-1beta in conjunctiva.	Latanoprost	23-34	interleukin 1 beta	Mus musculus	114-122
29980196-8	2018	In mouse primary microglia, recombinant SAA but not S. pneumoniae stimulated TNFalpha, IL-1beta, IL-6 and CCL-2 expression, and this response was completely blocked by the pro-resolving Fpr2 agonist aspirin-triggered resolvin D1 (AT-RvD1).	Aspirin	199-206	interleukin 1 beta	Mus musculus	87-95
29742623-7	2018	Propofol application also decreased LPS-induced Cox-2, IL-6, iNOS, TNF-alpha, and IL-1beta mRNA expression and induced significant protein kinase B (PKB) phosphorylation in BV2 cells.	Propofol	0-8	interleukin 1 beta	Mus musculus	82-90
29802156-13	2018	In vitro, curcumin treatment improved IL-1beta induced autophagy inhibition, cell viability decrease, and apoptosis.	Curcumin	10-18	interleukin 1 beta	Mus musculus	38-46
29655166-5	2018	PA significantly decreased the levels of interleukin-6 (IL-6), IL-1beta, tumor necrosis factor-alpha (TNF-alpha) in serum and hippocampus of MRL/lpr mice.	peoniflorin	0-2	interleukin 1 beta	Mus musculus	63-71
29549584-7	2018	In addition, the expressions of interleukin-1beta, interleukin-6, monocyte chemoattractant protein-1, intercellular adhesion molecule 1 and infiltration of macrophages in kidney tissues were decreased in acetylshikonin-treated diabetic mice.	acetylshikonin	204-218	interleukin 1 beta	Mus musculus	32-49
29280143-6	2018	Further experiments showed that PPEE treatment increased the secretion of macrophage-derived cytokines such as interleukin-1beta, tumor necrosis factor-alpha, and interleukin-12, and macrophage-activating cytokines interferon-gamma and interleukin-10 compared with untreated control.	ppee	32-36	interleukin 1 beta	Mus musculus	111-157
30140411-9	2018	The expression of TNF-alpha, IL-6 and IL-1beta decreased to 30-50% and 70-75% in the high-dose (160 nM) and low-dose (40 and 80 nM) GBA groups, respectively.	gambogic acid	132-135	interleukin 1 beta	Mus musculus	38-46
30140411-11	2018	Conclusion: These data suggested that GBA inhibited LPS-induced production of pro-inflammatory cytokines including TNF-alpha, IL-6 and IL-1beta mainly through the suppression of the p38 pathway.	gambogic acid	38-41	interleukin 1 beta	Mus musculus	135-143
29492987-0	2018	Size-dependent superparamagnetic iron oxide nanoparticles dictate interleukin-1beta release from mouse bone marrow-derived macrophages.	ferric oxide	33-43	interleukin 1 beta	Mus musculus	66-83
29769270-4	2018	In this article, we demonstrate that the inflammasome activation and the subsequent release of IL-1beta are central effectors of the action of GLA-SE, as infiltration of innate cells into the draining lymph nodes and production of IFN-gamma are reduced in ASC-/- animals.	gamma-Linolenic Acid	143-146	interleukin 1 beta	Mus musculus	95-103
29783158-8	2018	Pirfenidone substantially reduced NLRP3 and ASC expression and inhibited caspase-1 activation and IL-1beta maturation in lung tissues.	pirfenidone	0-11	interleukin 1 beta	Mus musculus	98-106
30381123-8	2018	Results beta-aescin can significantly reduce the pathological changes of lung tissue, lower PaCO2 while increase PaO2 and D/W ratio, down-regulate the expression of TNF-alpha, IL-1beta and IL-6 in LPS-ALI mice.	Escin	8-19	interleukin 1 beta	Mus musculus	176-184
29680917-3	2018	The results showed that production of TNF-alpha, IL-1beta, IL-6, and NO and TNF-alpha, IL-1beta, IL-6, and iNOS mRNA were inhibited by scutellarin, which was independent of cytotoxicity as assessed by a CCK8 assay.	scutellarin	135-146	interleukin 1 beta	Mus musculus	49-57
29680917-3	2018	The results showed that production of TNF-alpha, IL-1beta, IL-6, and NO and TNF-alpha, IL-1beta, IL-6, and iNOS mRNA were inhibited by scutellarin, which was independent of cytotoxicity as assessed by a CCK8 assay.	scutellarin	135-146	interleukin 1 beta	Mus musculus	87-95
29960988-8	2018	In addition, DHA treatment selectively decreased plaque endothelial IL-1beta (P&lt;0.01).	Docosahexaenoic Acids	13-16	interleukin 1 beta	Mus musculus	68-76
29960988-9	2018	CONCLUSIONS: Our findings revealed that raised blood pressure can be reduced by inhibiting IL-1 indirectly by administration of DHA in the diet through a mechanism that involves a reduction in wall shear stress and local expression of the proinflammatory cytokine IL-1beta.	Docosahexaenoic Acids	128-131	interleukin 1 beta	Mus musculus	264-272
30111058-5	2018	High dose of BAEB group and Mesalazine group could improve the colonic pathology, decrease IL-6, IL-8, IL-1beta, HBD-2, HBD-3 expression level.	baeb	13-17	interleukin 1 beta	Mus musculus	103-111
30111058-5	2018	High dose of BAEB group and Mesalazine group could improve the colonic pathology, decrease IL-6, IL-8, IL-1beta, HBD-2, HBD-3 expression level.	Mesalamine	28-38	interleukin 1 beta	Mus musculus	103-111
29752894-13	2018	Tissue homogenate levels of TNF-alpha, IL-6, IL-1beta and the renal expression of tissue nitrites were also significantly decreased in D-Pinitol treated mice.	pinitol	135-144	interleukin 1 beta	Mus musculus	45-53
30002631-10	2018	Furthermore, the phosphorylation of AMPK induced by ATP in LPS-primed macrophages was significantly suppressed by cyclic stretch, indicating that cyclic stretch negatively regulates IL-1beta secretion through the inhibition of caspase-1 activity by attenuating the AMPK pathway.	Adenosine Triphosphate	52-55	interleukin 1 beta	Mus musculus	182-190
29753610-0	2018	Improvement of hyperglycemia in a murine model of insulin resistance and high glucose- and inflammasome-mediated IL-1beta expressions in macrophages by silymarin.	Glucose	78-85	interleukin 1 beta	Mus musculus	113-121
29945883-6	2018	MEG3-4-mediated sponging of miR-138 in the cytoplasm increased the autocrine activity of IL-1beta that subsequently induced a negative feedback mechanism mediated by nuclear factor kappaB that decreased MEG3-4 abundance and inflammatory cytokine production.	mir-138	28-35	interleukin 1 beta	Mus musculus	89-97
29753610-0	2018	Improvement of hyperglycemia in a murine model of insulin resistance and high glucose- and inflammasome-mediated IL-1beta expressions in macrophages by silymarin.	Silymarin	152-161	interleukin 1 beta	Mus musculus	113-121
29946114-6	2018	We found that 2ccPA prevents a TBI-induced increase in the mRNA expression of Il-1beta, Il-6, Tnf-alpha and Tgf-beta1.	2-carba-cyclic phosphatidic acid	14-19	interleukin 1 beta	Mus musculus	78-86
29746861-4	2018	Additionally, iTRAQ assay revealed that IL-1beta induced activation of NF-kappaB inhibitor alpha/beta were remarkably downregulated by lenalidomide, showing that lenalidomide impaired NF-kappaB signaling in osteocytes for inhibiting the expression of osteoclast specific genes in osteoclasts, which was further confirmed by KEGG pathway analysis and Western blot.	Lenalidomide	135-147	interleukin 1 beta	Mus musculus	40-48
29746861-4	2018	Additionally, iTRAQ assay revealed that IL-1beta induced activation of NF-kappaB inhibitor alpha/beta were remarkably downregulated by lenalidomide, showing that lenalidomide impaired NF-kappaB signaling in osteocytes for inhibiting the expression of osteoclast specific genes in osteoclasts, which was further confirmed by KEGG pathway analysis and Western blot.	Lenalidomide	162-174	interleukin 1 beta	Mus musculus	40-48
29746861-0	2018	Lenalidomide regulates osteocytes fate and related osteoclastogenesis via IL-1beta/NF-kappaB/RANKL signaling.	Lenalidomide	0-12	interleukin 1 beta	Mus musculus	74-82
29746861-6	2018	Together, these results suggest that lenalidomide regulates osteocyte fate by attenuating IL-1beta/NF-kappaB signaling, thereby inhibiting RANKL expression for the attenuated osteoclastogenesis both in vitro and vivo, indicating a more efficient remedy among future anti-osteoclastogenesis approaches.	Lenalidomide	37-49	interleukin 1 beta	Mus musculus	90-98
29746861-3	2018	Our data revealed that lenalidomide treatment notably rescued IL-1beta induced loss of osteocyte viability by inhibiting osteocyte apoptosis with decreased osteoclast-related factors, RANKL and Sclerostin, as demonstrated by the restricted osteoclast formation and reduced bone resorption.	Lenalidomide	23-35	interleukin 1 beta	Mus musculus	62-70
29977244-6	2018	Pharmacological inhibition of cathepsin activity with CA074-Me resulted in a substantial reduction of both mature IL-1beta production and caspase-1 activation in infected macrophages.	CA 074 methyl ester	54-62	interleukin 1 beta	Mus musculus	114-122
29871974-9	2018	Nobiletin significantly altered the expression of PCNA, VEGF, and E-cadherin in ectopic endometrium, as well as the levels of IL-6, IL-1beta, TNF-alpha, MMP-1, and MMP-3.	nobiletin	0-9	interleukin 1 beta	Mus musculus	132-140
29929563-11	2018	Additionally, PC blocks the maturation of interleukin-1beta, which is a critical substrate of MMPs, and markedly suppresses CCI-induced MAPK phosphorylation and neuronal and microglia activation, including the reduced phosphorylation of protein kinase C gamma and NMDAR1.	Proanthocyanidins	14-16	interleukin 1 beta	Mus musculus	42-59
29933379-7	2018	The effects of TNBS treatment and IL-1beta on CMMC function were determined using a specialized organ bath.	7-(chlorocarbonylmethoxy)-4-methylcoumarin	46-50	interleukin 1 beta	Mus musculus	34-42
29977244-8	2018	These observations suggest that during Mtb infection, lysosomal release of activated CTSB and possibly other cathepsins inhibitable by CA07-Me is critical for the induction of inflammasome-mediated IL-1beta processing by regulating NLRP3-inflammasome assembly in the cytosol.	ca07-me	135-142	interleukin 1 beta	Mus musculus	198-206
29446321-4	2018	To induce IL-1beta expression in the pulmonary epithelium of mice with a tetracycline-inducible human IL-1beta transgene, doxycycline was administered via intraperitoneal injections to bitransgenic pups and their littermate controls on postnatal days (PN) 0, 0.5, and 1.	Tetracycline	73-85	interleukin 1 beta	Mus musculus	10-18
29680708-5	2018	We also showed that resveratrol treatment decreased IL-1beta, IL-6, TNF-alpha, PCNA, Bcl-2, and acetyl-p65 levels, but increased Bax and caspase 3 levels in hippocampus, suggesting a suppressive effect of resveratrol on cellular neuroinflammation and proliferation while a promotive effect on apoptosis of microglia in hippocampus.	Resveratrol	20-31	interleukin 1 beta	Mus musculus	52-60
29907781-6	2018	Interestingly, SGRS (30 mg/kg) suppressed carrageenan-induced elevation of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 mRNA levels as well as COX-2 and NF-kappaB protein levels, suggesting SGRS may possess anti-inflammatory activities.	Carrageenan	42-53	interleukin 1 beta	Mus musculus	99-107
29896426-6	2018	More interestingly, the high cholesterol diet not only improved NLRP3 inflammasome activation and IL-1beta expression, but also increased levels of anti-inflammatory cytokines IL-4 and IL-6 in the hippocampus of old mice, suggesting playing pro- and anti-neuroinflammatory effects.	Cholesterol	29-40	interleukin 1 beta	Mus musculus	98-106
29785433-6	2018	In the prevention or cure groups, the quantitative real-time polymerase chain reaction (qRT-PCR) results revealed that DHA (44.0 mg kg-1 and 88.0 mg kg-1) could enhance the production of cytokines IL-1beta, IL-2, TNF-alpha and IFN-gamma in the spleen of immunosuppressive mice.	Docosahexaenoic Acids	119-122	interleukin 1 beta	Mus musculus	197-205
29899226-5	2018	Furthermore, APTH and S-(-)-trolline (10) inhibited induction of inflammatory cytokines or mediators such as interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) via suppression of nuclear factor kappaB (NF-kappaB) translocation into the nucleus.	apth	13-17	interleukin 1 beta	Mus musculus	109-126
29899226-5	2018	Furthermore, APTH and S-(-)-trolline (10) inhibited induction of inflammatory cytokines or mediators such as interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) via suppression of nuclear factor kappaB (NF-kappaB) translocation into the nucleus.	apth	13-17	interleukin 1 beta	Mus musculus	128-136
29899226-5	2018	Furthermore, APTH and S-(-)-trolline (10) inhibited induction of inflammatory cytokines or mediators such as interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) via suppression of nuclear factor kappaB (NF-kappaB) translocation into the nucleus.	trolline	22-36	interleukin 1 beta	Mus musculus	109-126
29899226-5	2018	Furthermore, APTH and S-(-)-trolline (10) inhibited induction of inflammatory cytokines or mediators such as interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) via suppression of nuclear factor kappaB (NF-kappaB) translocation into the nucleus.	trolline	22-36	interleukin 1 beta	Mus musculus	128-136
29620052-6	2018	IL-1beta treatment increased cholesterol accumulation in HK-2 cells, leading to greatly increased ROS production, ECM protein expression levels, which was accompanied by the upregulated expression levels of proteins in the CXCL16 pathway.	Cholesterol	29-40	interleukin 1 beta	Mus musculus	0-8
29620052-6	2018	IL-1beta treatment increased cholesterol accumulation in HK-2 cells, leading to greatly increased ROS production, ECM protein expression levels, which was accompanied by the upregulated expression levels of proteins in the CXCL16 pathway.	ros	98-101	interleukin 1 beta	Mus musculus	0-8
29446321-4	2018	To induce IL-1beta expression in the pulmonary epithelium of mice with a tetracycline-inducible human IL-1beta transgene, doxycycline was administered via intraperitoneal injections to bitransgenic pups and their littermate controls on postnatal days (PN) 0, 0.5, and 1.	Doxycycline	122-133	interleukin 1 beta	Mus musculus	10-18
29446321-9	2018	Early IL-1beta production caused goblet cell hyperplasia, enhanced calcium-activated chloride channel 3 (CLCA3) protein expression, and increased airway reactivity in response to methacholine on PN42.	Methacholine Chloride	179-191	interleukin 1 beta	Mus musculus	6-14
29549723-11	2018	In parallel, SB-431542 blocked DNCB-induced elevation in serum levels of TNF-alpha, TGF-beta1, TGF-betaR1, LAP, IL-1beta, IL-6 and IgE.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	13-22	interleukin 1 beta	Mus musculus	112-120
29554596-6	2018	The treatment with quercetin also inhibited zymosan-induced depletion of reduced glutathione (GSH) levels, TNFalpha and IL-1beta production, and gp91phox, prepro-endothelin-1 (preproET-1), and cyclooxygenase-2 mRNA expression.	Quercetin	19-28	interleukin 1 beta	Mus musculus	120-128
29765479-7	2018	Furthermore, evodiamine inhibited significantly glial cell activation and neuroinflammation (TNF-alpha, IL-1beta, and IL-6 levels) in the hippocampus.	evodiamine	13-23	interleukin 1 beta	Mus musculus	104-112
29604586-8	2018	Sinigrin also inhibited the production of pro-inflammatory cytokines including tumor necrosis factor -alpha (TNF-alpha) and interleukin (IL)-6, IL-1beta and IL-18.	sinigrin	0-8	interleukin 1 beta	Mus musculus	144-152
29580411-4	2018	ELISA determination revealed that cDHP can inhibit CS-induced enhancement in TNF-alpha and IL-1beta secretion in serum and lung.	gimeracil	34-38	interleukin 1 beta	Mus musculus	91-99
29580411-4	2018	ELISA determination revealed that cDHP can inhibit CS-induced enhancement in TNF-alpha and IL-1beta secretion in serum and lung.	Cesium	51-53	interleukin 1 beta	Mus musculus	91-99
29428678-8	2018	At 20muM dilution, both CHX and EGCG significantly increased the secretion of IL-1beta, IL-10, IL-12, KC, MIP-1alpha, IFN-gamma and IL-6 (p&lt;0.05).	Chlorhexidine	24-27	interleukin 1 beta	Mus musculus	78-86
29428678-8	2018	At 20muM dilution, both CHX and EGCG significantly increased the secretion of IL-1beta, IL-10, IL-12, KC, MIP-1alpha, IFN-gamma and IL-6 (p&lt;0.05).	epigallocatechin gallate	32-36	interleukin 1 beta	Mus musculus	78-86
29549723-11	2018	In parallel, SB-431542 blocked DNCB-induced elevation in serum levels of TNF-alpha, TGF-beta1, TGF-betaR1, LAP, IL-1beta, IL-6 and IgE.	Dinitrochlorobenzene	31-35	interleukin 1 beta	Mus musculus	112-120
29355056-12	2018	TCA treatment also diminished the mRNA expression level and secretion of IL-1beta, IL-6 and TNF-alpha in LPS-activated macrophages.	cinnamaldehyde	0-3	interleukin 1 beta	Mus musculus	73-81
29732583-12	2018	ECG produced a significant (p &lt; .001) reduction in plasma PGE2 (by 27, 38, and 50%), TNF-alpha (15, 33, and 41%), IL-1beta (17, 25, and 33%), and IL-6 (22, 32, and 43%), at the tested doses, respectively.	epicatechin gallate	0-3	interleukin 1 beta	Mus musculus	117-125
29696536-8	2018	Cytokines that mediate inflammatory responses including TNF-alpha and IL-1beta were differentially regulated in Cldn6 TG mice and controls following DPM exposure.	dpm	149-152	interleukin 1 beta	Mus musculus	70-78
29904414-2	2018	Exogenous addition of recombinant PYNOD to mixed glial cultures may suppress caspase-1 activation and IL-1beta secretion induced by Abeta.	UNII-042A8N37WH	132-137	interleukin 1 beta	Mus musculus	102-110
29621733-3	2018	Our findings demonstrated that a single injection of APAP (250 mg/kg) increased the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta); such increases were attenuated by pretreatment of mice with 20(R)-Rg3 for seven days.	Acetaminophen	53-57	interleukin 1 beta	Mus musculus	205-222
29508185-11	2018	In addition, gingerol also observably inhibited LPS-induced TNF-alpha, IL-1beta, IL-6, and PGE2 (p &lt; 0.01) expression and secretion in a dose-dependent manner.	gingerol	13-21	interleukin 1 beta	Mus musculus	71-79
29655055-3	2018	The levels of the pro-inflammatory cytokines interleukin (IL)-1beta, IL-6 and tumour necrosis factor-alpha were decreased by GE, metformin and fasudil in diabetic db/db mice.	Metformin	129-138	interleukin 1 beta	Mus musculus	45-67
29621733-3	2018	Our findings demonstrated that a single injection of APAP (250 mg/kg) increased the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta); such increases were attenuated by pretreatment of mice with 20(R)-Rg3 for seven days.	Acetaminophen	53-57	interleukin 1 beta	Mus musculus	224-232
29655055-3	2018	The levels of the pro-inflammatory cytokines interleukin (IL)-1beta, IL-6 and tumour necrosis factor-alpha were decreased by GE, metformin and fasudil in diabetic db/db mice.	fasudil	143-150	interleukin 1 beta	Mus musculus	45-67
29508185-12	2018	At the genetic level, after the intervention of gingerol, mRNA transcriptions of iNOS, COX-2, IL-6, and IL-1beta were all decreased.	gingerol	48-56	interleukin 1 beta	Mus musculus	104-112
29627576-6	2018	The elevation of prefrontal cortex pro-inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) was decreased by magnolol.	magnolol	182-190	interleukin 1 beta	Mus musculus	70-87
29689498-4	2018	Cirsitakaoside could suppress the production of pro-inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) in a dose-dependent manner in LPS-stimulated mouse peritoneal macrophages and RAW264.7 cells.	cirsimarin	0-14	interleukin 1 beta	Mus musculus	102-110
29689498-4	2018	Cirsitakaoside could suppress the production of pro-inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) in a dose-dependent manner in LPS-stimulated mouse peritoneal macrophages and RAW264.7 cells.	cirsimarin	0-14	interleukin 1 beta	Mus musculus	83-100
29627576-6	2018	The elevation of prefrontal cortex pro-inflammatory cytokines such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) was decreased by magnolol.	magnolol	182-190	interleukin 1 beta	Mus musculus	89-97
29984177-6	2018	Further, the role of inflammatory cytokines like TNF - alpha, IL - 1beta and free radicals in the action of trimethoxy flavones was investigated using in vitro assays.	trimethoxy flavones	108-127	interleukin 1 beta	Mus musculus	62-72
29693122-6	2018	The results revealed that the serum levels of TNF-alpha, interleukin (IL)-1beta, IL-4 and IL-6 were significantly upregulated in a mouse model of iodoacetate-induced osteoarthritis compared with healthy mice (P&lt;0.01).	Iodoacetates	146-157	interleukin 1 beta	Mus musculus	57-79
29454997-7	2018	Furthermore, when HUVECs were co-cultured with RAW264.7 cells, lipopolysaccharide-induced expression of interleukin (IL)-1beta and IL-6 was enhanced by magnesium deficiency, depending on the presence of RAW264.7 cells.	Magnesium	152-161	interleukin 1 beta	Mus musculus	104-126
29675728-9	2018	We found that CAY10683 could inhibit expression levels of inflammatory cytokine TNF-alpha and IL-1beta in LPS activated BV2 microglial cells and LPS induced mice neuroinflammation.	santacruzamate A	14-22	interleukin 1 beta	Mus musculus	94-102
29693192-5	2018	In our study, we found that SR dose-dependently ameliorated skin cancer incidence and the multiplicity in the animal models by reducing the release of inflammation-related cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-18 (IL-18), interleukin-6 (IL-6), cyclooxygenase 2 (COX2) and transforming growth factor beta-1 (TGF-beta1).	rhodioloside	28-30	interleukin 1 beta	Mus musculus	253-261
29660653-8	2018	The increased levels of IL-1beta or TBARS induced by pretreatment with PTX or PSNL were reduced by rosuvastatin.	Paclitaxel	71-74	interleukin 1 beta	Mus musculus	24-32
29693192-5	2018	In our study, we found that SR dose-dependently ameliorated skin cancer incidence and the multiplicity in the animal models by reducing the release of inflammation-related cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-18 (IL-18), interleukin-6 (IL-6), cyclooxygenase 2 (COX2) and transforming growth factor beta-1 (TGF-beta1).	rhodioloside	28-30	interleukin 1 beta	Mus musculus	234-251
29660653-8	2018	The increased levels of IL-1beta or TBARS induced by pretreatment with PTX or PSNL were reduced by rosuvastatin.	Rosuvastatin Calcium	99-111	interleukin 1 beta	Mus musculus	24-32
29861476-8	2018	Furthermore, phosphorylation of NF-kappaB p65 and expression of IL-1beta was remarkably upregulated in IDH2 KO mice fed fructose, and expression of IkappaBalpha was decreased by fructose treatment in both WT and IDH2 KO groups.	Fructose	120-128	interleukin 1 beta	Mus musculus	64-72
29505886-4	2018	Moreover, OAA treatment significantly decreased the elevations of IL-1beta, IL-6, TNF-alpha, TGF-beta1, and fibronectin, and the activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in the lungs of PHMG-P-treated mice.	Oxaloacetic Acid	10-13	interleukin 1 beta	Mus musculus	66-74
29681573-7	2018	Expression of the pro-inflammatory molecule interleukin-1beta was markedly upregulated in vehicle-treated mice, but was inhibited to a similar extent by treatment with amlodipine or the R+ enantiomer.	Amlodipine	168-178	interleukin 1 beta	Mus musculus	44-61
29862167-6	2018	RESULTS: In C57BL/6 mice, rapamycin treatment decreased the clinical scores and production of the pro-inflammatory cytokine, IL-1beta.	Sirolimus	26-35	interleukin 1 beta	Mus musculus	125-133
29667667-3	2018	In this study, we found that alpha-cyperone markedly decreased the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in LPS-induced BV-2 cells.	alpha-cyperone	29-43	interleukin 1 beta	Mus musculus	147-164
29667667-3	2018	In this study, we found that alpha-cyperone markedly decreased the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in LPS-induced BV-2 cells.	alpha-cyperone	29-43	interleukin 1 beta	Mus musculus	166-174
29653152-0	2018	Low-dose Norfloxacin-treated leptospires induce less IL-1beta release in J774A.1 cells following discrepant leptospiral gene expression.	Norfloxacin	9-20	interleukin 1 beta	Mus musculus	53-61
29563064-6	2018	According to the analysis of western-blot and RT-PCR detection, alpha-mangostin pretreatment validly inhibited the phosphorylation of ERK, JNK and p38 MAPK induced by APAP, which was consistent with the changes of TNF-alpha, IL-6 and IL-1beta levels; the phosphorylation of IkappaBalpha and the translocation of NF-kappaBp65 were also attenuated by alpha-mangostin.	mangostin	64-79	interleukin 1 beta	Mus musculus	234-242
29622518-7	2018	Final experimental results showed that Sit-N significantly decreased the serum activity of aspartate transaminase (AST) and alanine aminotransferase (ALT); Sit-N also markedly reduced tumor necrosis factor (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) levels.	sit-n	39-44	interleukin 1 beta	Mus musculus	219-236
29622518-7	2018	Final experimental results showed that Sit-N significantly decreased the serum activity of aspartate transaminase (AST) and alanine aminotransferase (ALT); Sit-N also markedly reduced tumor necrosis factor (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) levels.	sit-n	39-44	interleukin 1 beta	Mus musculus	238-246
29622518-7	2018	Final experimental results showed that Sit-N significantly decreased the serum activity of aspartate transaminase (AST) and alanine aminotransferase (ALT); Sit-N also markedly reduced tumor necrosis factor (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) levels.	sit-n	156-161	interleukin 1 beta	Mus musculus	219-236
29610142-4	2018	Phagocytosis of CS particles is essential for the production of LTB4 and IL-1beta in mouse macrophages, mast cells, and neutrophils.	Cesium	16-18	interleukin 1 beta	Mus musculus	73-81
29622518-7	2018	Final experimental results showed that Sit-N significantly decreased the serum activity of aspartate transaminase (AST) and alanine aminotransferase (ALT); Sit-N also markedly reduced tumor necrosis factor (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) levels.	sit-n	156-161	interleukin 1 beta	Mus musculus	238-246
29868580-13	2018	The findings showed the significant blood glucose levels regulation capacity and declination of IL-1beta concentration in all transplanted mice.	Glucose	42-49	interleukin 1 beta	Mus musculus	96-104
29563064-4	2018	The results showed that alpha-mangostin effectively decreased the serum levels of alanine aminotransferase, aspartate transaminase, tumor necrosis factor (TNF-alpha), interleukin-1beta and 6 (IL-1beta, IL-6), and hepatic malondialdehyde level; and recovered hepatic glutathione (GSH), superoxide dismutase and catalase activities.	mangostin	24-39	interleukin 1 beta	Mus musculus	167-190
29563064-4	2018	The results showed that alpha-mangostin effectively decreased the serum levels of alanine aminotransferase, aspartate transaminase, tumor necrosis factor (TNF-alpha), interleukin-1beta and 6 (IL-1beta, IL-6), and hepatic malondialdehyde level; and recovered hepatic glutathione (GSH), superoxide dismutase and catalase activities.	mangostin	24-39	interleukin 1 beta	Mus musculus	192-200
29610142-6	2018	Activation of the JNK pathway is essential for both CS-induced LTB4 and IL-1beta production.	Cesium	52-54	interleukin 1 beta	Mus musculus	72-80
29421335-5	2018	After subcutaneous injection of MPTP (25 mg/kg) every 4 days for 40-days, immune responses became unbalanced, with increased IL-1beta concentrations.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	32-36	interleukin 1 beta	Mus musculus	125-133
29854830-6	2018	DCA enema significantly aggravated DSS-induced colitis in mice and S1PR2 inhibitor as well as inflammasome inhibition by cathepsin B antagonist substantially reducing the mature IL-1beta production and alleviated colonic inflammation superimposed by DCA.	Dichloroacetic Acid	0-3	interleukin 1 beta	Mus musculus	178-186
29854837-4	2018	In addition, the mRNA expression of IL-1beta, IL-6, and TNF-alpha in peritoneal macrophages from sublancin- (1.0 mg/kg body weight) administered mice was significantly increased (P &lt; 0.05).	sublancin	97-106	interleukin 1 beta	Mus musculus	36-44
29635897-3	2018	The results show that HACP administration resulted in a remarkable immunomodulatory effect attributable to the increased spleen and thymus indices, unregulated CD4+/CD8+ ratios in spleen lymphocytes, and the augmentation of IL-1beta, IFN-gamma, and TNF-alpha productions in the serum of tumor-bearing mice.	hacp	22-26	interleukin 1 beta	Mus musculus	224-232
29773990-7	2018	Atorvastatin could also inhibit NLRP3 inflammasome activation and inflammatory cytokines, such as IL-1beta, TNF-alpha, and IL-18 secretion in vivo.	Atorvastatin	0-12	interleukin 1 beta	Mus musculus	98-106
29373036-7	2018	Expression of inflammation-related MMPs (MMP-12 and MMP-13) and inflammatory cytokines (IL-1beta and monocyte chemoattractant protein-1) was elevated to a greater extent in iron-overloaded Timp3-/- livers.	Iron	173-177	interleukin 1 beta	Mus musculus	88-96
29501766-10	2018	The concentrations and expression levels of pro-inflammatory factors including TNF-alpha, IL-1beta, IL-6, PGE-2, COX-2 were significantly reduced after beta-Amyrin treatment in LPS/IFN-gamma-induced microglial cells (p &lt; 0.05-0.001).	beta-amyrin	152-163	interleukin 1 beta	Mus musculus	90-98
29765317-4	2018	STS reduced CS- and cigarette smoke extract (CSE)-induced upregulation of tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta in the lungs and macrophages.	Cesium	12-14	interleukin 1 beta	Mus musculus	112-134
29655911-1	2018	Riparin II (RipII) has an anti-inflammatory activity potentially due its ability to decrease TNF-alpha and IL-1beta production and its histamine antagonism.	N-(2-hydroxybenzoyl)tyramine	0-10	interleukin 1 beta	Mus musculus	107-115
29655911-1	2018	Riparin II (RipII) has an anti-inflammatory activity potentially due its ability to decrease TNF-alpha and IL-1beta production and its histamine antagonism.	N-(2-hydroxybenzoyl)tyramine	12-17	interleukin 1 beta	Mus musculus	107-115
29453978-6	2018	Co-administration of VLF with morphine attenuated morphine-induced analgesic tolerance and prevented the upregulation of proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-6), NO, and malondialdehyde in brains of mice with induced morphine tolerance; chronic VLF administration inhibited this decrease in brain-derived neurotrophic factor, total thiol, and GPx levels.	Morphine	30-38	interleukin 1 beta	Mus musculus	159-167
29114910-7	2018	The mice exposed to CPZ for 10 days showed significantly lower spontaneous alternation in the Y-maze, lower activity of total superoxide dismutase, and glutathione peroxidase, but higher levels of malondialdehyde in the cerebral cortex and hippocampus, elevated concentrations of interleukin-1beta and tumor necrosis factor-alpha in the brain regions mentioned above and caudate putamen, and a decreased number of mature oligodendrocytes, but increased number of microglia in all the brain regions examined.	Cuprizone	20-23	interleukin 1 beta	Mus musculus	280-329
28770639-4	2018	Serum analysis of NRG and MTX groups showed a reduction in the cytokines such as the levels of tumour necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and interleukin 1beta (IL-1beta) in comparison to PRG group.	Methotrexate	26-29	interleukin 1 beta	Mus musculus	162-179
28770639-4	2018	Serum analysis of NRG and MTX groups showed a reduction in the cytokines such as the levels of tumour necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and interleukin 1beta (IL-1beta) in comparison to PRG group.	Methotrexate	26-29	interleukin 1 beta	Mus musculus	181-189
29390063-6	2018	Pretreatment with pramipexole (PPX), a preferential D3R agonist, showed antidepressant effects on LPS-induced depression-like behavior through preventing changes in LPS-induced proinflammatory cytokines (tumour necrosis factor-alpha, interleukin-1beta, and interleukin-6), BDNF, and ERK1/2-CREB signaling pathway in the VTA and NAc.	Pramipexole	18-29	interleukin 1 beta	Mus musculus	234-251
29390063-6	2018	Pretreatment with pramipexole (PPX), a preferential D3R agonist, showed antidepressant effects on LPS-induced depression-like behavior through preventing changes in LPS-induced proinflammatory cytokines (tumour necrosis factor-alpha, interleukin-1beta, and interleukin-6), BDNF, and ERK1/2-CREB signaling pathway in the VTA and NAc.	Pramipexole	31-34	interleukin 1 beta	Mus musculus	234-251
29571724-9	2018	We also found that the expression of pro-inflammatory cytokines, TNF-alpha, IL-6 and IL-1beta were inhibited by puerarin.	puerarin	112-120	interleukin 1 beta	Mus musculus	85-93
29554498-7	2018	Mg2+, especially at 5 mM, raised proliferation rates of MSCs, and modulated immune responses by decreasing levels of IL-1beta and IL-6, and by increasing levels of IL-10 and PGE2 in cells stimulated with LPS or TNF-alpha.	magnesium ion	0-4	interleukin 1 beta	Mus musculus	117-125
29554498-10	2018	In addition, conditioned media from MSCs cultured at 5 mM of Mg2+ modulated the production profile of cytokines, especially of IL-1beta and IL-6 in macrophages.	magnesium ion	61-65	interleukin 1 beta	Mus musculus	127-135
29530598-8	2018	In cirrhotic mice, administration of BAR704, 15 mg/kg for 9 weeks, spared the liver biosynthetic activity (bilirubin and albumin plasma levels), reduced liver fibrosis score (Sirius red staining), expression of pro-fibrogenetic (Colalpha1alpha, TGFbeta and alphaSMA) and inflammatory genes (IL-1beta, TNFalpha) and portal pressure.	bar704	37-43	interleukin 1 beta	Mus musculus	291-299
29568928-9	2018	The findings suggested that UA may protect against sepsis-induced AKI by inhibiting reactive oxygen species and inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6, in the kidney from septic mice.	ursolic acid	28-30	interleukin 1 beta	Mus musculus	175-197
29731434-7	2018	In our study, compared with model group, the concentrations and contents of ALT, AST, TNF-alpha, IL-1beta and MDA were reduced and activities of SOD were increase in H-KSCP (1.2mg/10 g)-pretreated mice (P&lt;0.01).	h-kscp	166-172	interleukin 1 beta	Mus musculus	97-105
29922130-8	2018	Moreover, IL-33 and SAL alone, or their combination prevented TBI-induced the increase of IL-1beta and TNF-alpha levels, suppressed the up-regulation of ER stress, apoptosis and autophagy after TBI.	salubrinal	20-23	interleukin 1 beta	Mus musculus	90-98
29499192-0	2018	Evidence for the involvement of TNF-alpha, IL-1beta and IL-10 in the antinociceptive and anti-inflammatory effects of indole-3-guanylhydrazone hydrochloride, an aromatic aminoguanidine, in rodents.	indole-3-guanylhydrazone hydrochloride	118-156	interleukin 1 beta	Mus musculus	43-51
29592953-9	2018	However, the therapeutic effects of LY500307 treatment for suppression of lung metastasis was attenuated in IL1B-/- murine models, due to failure to induce antitumor neutrophil infiltration in the metastatic niche.	erteberel	36-44	interleukin 1 beta	Mus musculus	108-112
29669582-10	2018	Galantamine decreased the expression of microglia and astrocyte markers (CD11b and GFAP), pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha), and NF-kappaB p65 in the hippocampus of LPS-exposed mice.	Galantamine	0-11	interleukin 1 beta	Mus musculus	118-126
29665808-13	2018	Isoflurane activated NLRP3-caspase-1 pathway and increased the secretion of IL-18 and IL-1beta in cells pretreated with lipopolysaccharide but not in cells without pretreatment.	Isoflurane	0-10	interleukin 1 beta	Mus musculus	86-94
29983966-4	2018	Gelatin prevented the DSS-induced increase in interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in the colon, rather than in peripheral blood.	dss	22-25	interleukin 1 beta	Mus musculus	46-63
29983966-4	2018	Gelatin prevented the DSS-induced increase in interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in the colon, rather than in peripheral blood.	dss	22-25	interleukin 1 beta	Mus musculus	65-73
29736208-4	2018	Our experimental results demonstrated that Sch B inhibited production of IL-1beta, TNF-alpha, IL-6 and HMGB1 by LPS-activated RAW264.7 cells.	schizandrin B	43-48	interleukin 1 beta	Mus musculus	73-81
29849710-10	2018	Results indicated that berberine hydrochloride significantly attenuated neutrophil infiltration and dose-dependently decreased the secretion and mRNA expressions of TNF-alpha, IL-1beta, and IL-6 within a certain range.	berberine chloride	23-46	interleukin 1 beta	Mus musculus	176-184
29549176-0	2018	Curcumin Suppresses IL-1beta Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome.	Curcumin	0-8	interleukin 1 beta	Mus musculus	20-28
29549176-4	2018	We report that curcumin inhibited caspase-1 activation and IL-1beta secretion through suppressing LPS priming and the inflammasome activation pathway in mouse bone marrow-derived macrophages.	Curcumin	15-23	interleukin 1 beta	Mus musculus	59-67
29549176-8	2018	Importantly, in vivo data show that curcumin attenuated IL-1beta secretion and prevented high-fat diet-induced insulin resistance in wide-type C57BL/6 mice but not in Nlrp3-deficient mice.	Curcumin	36-44	interleukin 1 beta	Mus musculus	56-64
29456014-4	2018	The polysaccharide mixture and isolated fractions inhibited the production of inflammatory cytokines (TNF-alpha and IL-1beta) and mediator (NO) in RAW 264.7 cells stimulated with LPS.	Polysaccharides	4-18	interleukin 1 beta	Mus musculus	116-124
29621237-3	2018	Here, we show that activation of AAR pharmacologically by Halofuginone (HF) significantly inhibits production of the proinflammatory cytokine interleukin 1beta (IL-1beta) and provides protection from intestinal inflammation in mice.	halofuginone	58-70	interleukin 1 beta	Mus musculus	142-159
29501084-7	2018	Consistently, SR141716A promoted BV-2 microglia to release inflammatory factors (TNF-alpha, IL-1beta, IL-6) while inhibited the production of IL-10 and chemokines (MCP-1, CX3CL1).	Rimonabant	14-23	interleukin 1 beta	Mus musculus	92-100
29642894-10	2018	RO27-3225 administration increased the expression of MC4R and p-AMPK while decreasing p-JNK, p-p38 MAPK, TNF-alpha, and IL-1beta expression, which was reversed with inhibition of MC4R and AMPK.	butir-His-Phe-Arg-Trp-Sar-NH2	0-9	interleukin 1 beta	Mus musculus	120-128
30788937-14	2018	CONCLUSIONS: Ursolic acid has a obvious protective effect on myocardial injury in mice with diabetes induced by high-fat diet combined with low dose streptozotocin, and its mechanism may be associated with inhibiting NLRP3 inflammasome activation, reducing IL-1beta generation and alleviating myocardial inflammatory injury.	ursolic acid	13-25	interleukin 1 beta	Mus musculus	257-265
29675024-4	2018	In this study, we first analyzed a bleomycin-induced mouse model, which showed that higher expression of IL-1beta, but not IL-18, was correlated to pulmonary cell infiltration and fibrosis.	Bleomycin	35-44	interleukin 1 beta	Mus musculus	105-113
30788945-7	2018	RESULTS: Compared with sham group, serum levels of TNF-alpha, IL-1beta and IL-6, and osteolysis area were increased obviously in TCP group (P&lt;0.05), and serum level of T-AOC and SOD activity were decreased significantly in TCP group (P&lt;0.05), GRP78 expression, the ratio of p-PERK and PERK, p-eIF2alpha and eIF2alpha in the mouse calvaria of TCP group were up-regulated markedly.	N-(3,4,5-trichlorophenyl)succinimide	129-132	interleukin 1 beta	Mus musculus	62-70
30788945-8	2018	Compared with TCP group, serum levels of TNF-alpha, IL-1beta and IL-6, and osteolysis area were decreased markedly in NAC group (P&lt;0.05), serum level of T-AOC and SOD activity were increased obviously in NAC group (P&lt;0.05), and GRP78 expression, the ratio of p-PERK/PERK and p-eIF2alpha/eIF2alpha were obviously down-regulated.	Acetylcysteine	118-121	interleukin 1 beta	Mus musculus	52-60
29621237-3	2018	Here, we show that activation of AAR pharmacologically by Halofuginone (HF) significantly inhibits production of the proinflammatory cytokine interleukin 1beta (IL-1beta) and provides protection from intestinal inflammation in mice.	halofuginone	58-70	interleukin 1 beta	Mus musculus	161-169
29508169-18	2018	mRNA levels of NALP3, ASC, IL-1beta, IL-6, caspase-1, TNF-alpha, collagen-1, and collagen-3 significantly increased in the kidneys of the BTBR compared to the WT mice.	btbr	138-142	interleukin 1 beta	Mus musculus	27-35
29670526-5	2018	The effects of taraxasterol on LPS-induced TNF-alpha and IL-1beta production were detected by ELISA.	taraxasterol	15-27	interleukin 1 beta	Mus musculus	57-65
29670526-7	2018	The results showed that taraxasterol dose-dependently inhibited LPS-induced TNF-alpha and IL-1beta production and NF-kappaB activation.	taraxasterol	24-36	interleukin 1 beta	Mus musculus	90-98
29437575-4	2018	APPROACH AND RESULTS: The treatment with SFAs, such as palmitic acid and stearic acid, promoted IL-1beta release in murine primary macrophages while treatment with oleic acid inhibited SFA-induced IL-1beta release in a dose-dependent manner.	Palmitic Acid	55-68	interleukin 1 beta	Mus musculus	96-104
29437575-4	2018	APPROACH AND RESULTS: The treatment with SFAs, such as palmitic acid and stearic acid, promoted IL-1beta release in murine primary macrophages while treatment with oleic acid inhibited SFA-induced IL-1beta release in a dose-dependent manner.	Palmitic Acid	55-68	interleukin 1 beta	Mus musculus	197-205
29437575-4	2018	APPROACH AND RESULTS: The treatment with SFAs, such as palmitic acid and stearic acid, promoted IL-1beta release in murine primary macrophages while treatment with oleic acid inhibited SFA-induced IL-1beta release in a dose-dependent manner.	stearic acid	73-85	interleukin 1 beta	Mus musculus	96-104
29437575-4	2018	APPROACH AND RESULTS: The treatment with SFAs, such as palmitic acid and stearic acid, promoted IL-1beta release in murine primary macrophages while treatment with oleic acid inhibited SFA-induced IL-1beta release in a dose-dependent manner.	stearic acid	73-85	interleukin 1 beta	Mus musculus	197-205
29437575-4	2018	APPROACH AND RESULTS: The treatment with SFAs, such as palmitic acid and stearic acid, promoted IL-1beta release in murine primary macrophages while treatment with oleic acid inhibited SFA-induced IL-1beta release in a dose-dependent manner.	Oleic Acid	164-174	interleukin 1 beta	Mus musculus	197-205
29437575-4	2018	APPROACH AND RESULTS: The treatment with SFAs, such as palmitic acid and stearic acid, promoted IL-1beta release in murine primary macrophages while treatment with oleic acid inhibited SFA-induced IL-1beta release in a dose-dependent manner.	Fatty Acids	41-44	interleukin 1 beta	Mus musculus	96-104
29437575-4	2018	APPROACH AND RESULTS: The treatment with SFAs, such as palmitic acid and stearic acid, promoted IL-1beta release in murine primary macrophages while treatment with oleic acid inhibited SFA-induced IL-1beta release in a dose-dependent manner.	Fatty Acids	41-44	interleukin 1 beta	Mus musculus	197-205
29437575-6	2018	As well as IL-1beta release, the intracellular crystallization and lysosomal dysfunction were inhibited in the presence of oleic acid.	Oleic Acid	123-133	interleukin 1 beta	Mus musculus	11-19
29472233-7	2018	Mechanistically, IL-1beta treatment of isolated neutrophils induced nuclear localization of ceramide synthase 6 and synthesis of C16-ceramide, which was inhibited by IL-1RA or fumonisin B1, an inhibitor of ceramide synthesis.	N-palmitoylsphingosine	129-141	interleukin 1 beta	Mus musculus	17-25
29472233-7	2018	Mechanistically, IL-1beta treatment of isolated neutrophils induced nuclear localization of ceramide synthase 6 and synthesis of C16-ceramide, which was inhibited by IL-1RA or fumonisin B1, an inhibitor of ceramide synthesis.	fumonisin B1	176-188	interleukin 1 beta	Mus musculus	17-25
29541456-0	2018	Valproic acid attenuates nitric oxide and interleukin-1beta production in lipopolysaccharide-stimulated iron-rich microglia.	Valproic Acid	0-13	interleukin 1 beta	Mus musculus	42-59
29541456-6	2018	The results demonstrated that VPA attenuated the activation of iron-rich BV2 cells induced by LPS by down-regulating the mRNA expression of inducible nitric oxide (NO) synthase and interleukin 1beta (IL-1beta; P&lt;0.01), to ultimately reduce the production of NO and IL-1beta (P&lt;0.01).	Iron	63-67	interleukin 1 beta	Mus musculus	181-198
28833755-7	2018	In vitro, tacrolimus inhibited receptor activator of nuclear factor-kappaB ligand-mediated osteoclast formation augmented by interleukin-1beta, thapsigargin, or both.	Tacrolimus	10-20	interleukin 1 beta	Mus musculus	125-142
28833755-8	2018	Furthermore, tacrolimus inhibited glucose-regulated protein (GRP78), protein kinase R-like endoplasmic reticulum kinase, inositol-requiring enzyme 1 (IRE 1), and activating transcription factor 6 (ATF6) augmented by interleukin-1beta, thapsigargin, or both.	Tacrolimus	13-23	interleukin 1 beta	Mus musculus	216-233
29355515-0	2018	Spliceosome-Associated Protein 130 Exacerbates Alcohol-Induced Liver Injury by Inducing NLRP3 Inflammasome-Mediated IL-1beta in Mice.	Alcohols	47-54	interleukin 1 beta	Mus musculus	116-124
29355515-8	2018	IL-1beta expression was significantly down-regulated in Mincle KO mice compared with that in WT mice after alcohol consumption.	Alcohols	107-114	interleukin 1 beta	Mus musculus	0-8
29472233-7	2018	Mechanistically, IL-1beta treatment of isolated neutrophils induced nuclear localization of ceramide synthase 6 and synthesis of C16-ceramide, which was inhibited by IL-1RA or fumonisin B1, an inhibitor of ceramide synthesis.	Ceramides	92-100	interleukin 1 beta	Mus musculus	17-25
29532413-5	2018	Tryptanthrin (1) also downregulated the production of pro-inflammatory cytokines such as TNF-alpha, IL-6, and IL-1beta.	tryptanthrine	0-12	interleukin 1 beta	Mus musculus	110-118
29447945-6	2018	We found that Salmeterol (10-10 M-10-7 M) prevented the cleavage of caspase-1 and the activation of NLRP3 inflammasome, reduced the release of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in vitro.	Salmeterol Xinafoate	14-24	interleukin 1 beta	Mus musculus	214-231
29447945-6	2018	We found that Salmeterol (10-10 M-10-7 M) prevented the cleavage of caspase-1 and the activation of NLRP3 inflammasome, reduced the release of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in vitro.	Salmeterol Xinafoate	14-24	interleukin 1 beta	Mus musculus	233-241
29447945-8	2018	In vivo study showed that Salmeterol decreased the serum concentrations of pro-inflammatory cytokines IL-1beta and TNF-alpha, blocked cleavage of caspase-1 and release of IL-1beta in BMDM.	Salmeterol Xinafoate	26-36	interleukin 1 beta	Mus musculus	102-110
29447945-8	2018	In vivo study showed that Salmeterol decreased the serum concentrations of pro-inflammatory cytokines IL-1beta and TNF-alpha, blocked cleavage of caspase-1 and release of IL-1beta in BMDM.	Salmeterol Xinafoate	26-36	interleukin 1 beta	Mus musculus	171-179
29448086-11	2018	Blocking the activation of p38 MAPK by SB203580 prevented elevation of IL-1beta and IL-17A induced by DIDP and OVA sensitization and effectively alleviated Th17 type asthmatic lesions.	SB 203580	39-47	interleukin 1 beta	Mus musculus	71-79
29448086-11	2018	Blocking the activation of p38 MAPK by SB203580 prevented elevation of IL-1beta and IL-17A induced by DIDP and OVA sensitization and effectively alleviated Th17 type asthmatic lesions.	diisodecyl phthalate	102-106	interleukin 1 beta	Mus musculus	71-79
29111234-7	2018	Further, CXCL5 potentiated the secretion of IL-1beta from macrophages and palmitic acid, a fatty acid released from subcutaneous adipocytes, further enhanced IL-1beta secretion via endoplasmic reticulum stress induction.	Palmitic Acid	74-87	interleukin 1 beta	Mus musculus	158-166
29717417-9	2018	NaHS inhibited age-related increase in kidney cortical content of p21, IL-1beta, and IL-6, components of the senescence-associated secretory phenotype.	sodium bisulfide	0-4	interleukin 1 beta	Mus musculus	71-79
29350096-5	2018	RESULTS: CoNPs and Co2+ can induce the increase of ROS and inflammatory cytokines in Balb/3T3 cells, such as tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	Cobalt(2+)	19-23	interleukin 1 beta	Mus musculus	150-167
29350096-5	2018	RESULTS: CoNPs and Co2+ can induce the increase of ROS and inflammatory cytokines in Balb/3T3 cells, such as tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	Cobalt(2+)	19-23	interleukin 1 beta	Mus musculus	169-177
29393339-5	2018	H2O2-exposed fibroblasts exhibited activated NALP3 inflammasomes via increased NALP3, apoptosis-associated Speck-like protein and caspase-1 expression and the secretion of interleukin-1beta.	Hydrogen Peroxide	0-4	interleukin 1 beta	Mus musculus	172-189
29545882-7	2018	Notably, pterostilbene reduced Bcl-2-associated X protein expression, and levels of interleukin-1beta and tumor necrosis factor-alpha, and upregulated B-cell lymphoma 2 expression.	pterostilbene	9-22	interleukin 1 beta	Mus musculus	84-133
28988328-7	2018	Acacetin administration notably attenuated these changes and reduced tumor necrosis factor-alpha and interleukin-1beta in lung tissues.	acacetin	0-8	interleukin 1 beta	Mus musculus	101-118
29133093-5	2018	Polysaccharides induced RAW264.7 macrophage cells to release noticeable amounts of nitric oxide and cytokines including IL-1beta, TNF-alpha, IL-6, IL-10 and IL-12 through NF-kappaB and MAPKs signaling pathways.	Polysaccharides	0-15	interleukin 1 beta	Mus musculus	120-128
29111234-7	2018	Further, CXCL5 potentiated the secretion of IL-1beta from macrophages and palmitic acid, a fatty acid released from subcutaneous adipocytes, further enhanced IL-1beta secretion via endoplasmic reticulum stress induction.	Fatty Acids	91-101	interleukin 1 beta	Mus musculus	44-52
29438662-5	2018	Ac-YVAD-CHO, a caspase-1 inhibitor, inhibited ALN-augmented IL-1beta production induced by lipid A, although it did not affect ALN-induced cell death.	Lipid A	91-98	interleukin 1 beta	Mus musculus	60-68
29438662-7	2018	We also demonstrate that a Smad3 inhibitor (SIS3) suppressed ALN-augmented IL-1beta production.	Alendronate	61-64	interleukin 1 beta	Mus musculus	75-83
29438662-0	2018	Alendronate augments lipid A-induced IL-1beta release and Smad3/NLRP3/ASC-dependent cell death.	Alendronate	0-11	interleukin 1 beta	Mus musculus	37-45
29438662-0	2018	Alendronate augments lipid A-induced IL-1beta release and Smad3/NLRP3/ASC-dependent cell death.	Lipid A	21-28	interleukin 1 beta	Mus musculus	37-45
29438662-11	2018	Both anti-ASC and anti-NLRP3 antibodies suppressed ALN-induced cell death and caspase-1 release, but only anti-ASC antibody inhibited ALN-augmented IL-1beta production.	Alendronate	134-137	interleukin 1 beta	Mus musculus	148-156
29438662-2	2018	NBPs have inflammatory side effects, and ALN augments bacteria-induced interleukin (IL)-1beta production.	Alendronate	41-44	interleukin 1 beta	Mus musculus	71-93
29412160-6	2018	After adding p38 inhibitor, SB203580 to culture, the production of IL-1beta, IL-6, IL-10, TNF-alpha was significantly reduced as compared to visfatin only (P &lt; 0.01).	SB 203580	28-36	interleukin 1 beta	Mus musculus	67-75
29438662-3	2018	The present study aimed to examine whether ALN induces pyroptosis, a form of cell death associated with IL-1beta release, in macrophage-like J774.1 cells incubated with lipid A, a component of gram-negative bacteria.	Alendronate	43-46	interleukin 1 beta	Mus musculus	104-112
29438662-4	2018	Pretreatment of J774.1 cells with ALN increased lipid A-induced IL-1beta production and cell death, but not IL-6 and TNF-alpha production.	Alendronate	34-37	interleukin 1 beta	Mus musculus	64-72
29438662-4	2018	Pretreatment of J774.1 cells with ALN increased lipid A-induced IL-1beta production and cell death, but not IL-6 and TNF-alpha production.	Lipid A	48-55	interleukin 1 beta	Mus musculus	64-72
29438662-5	2018	Ac-YVAD-CHO, a caspase-1 inhibitor, inhibited ALN-augmented IL-1beta production induced by lipid A, although it did not affect ALN-induced cell death.	Alendronate	46-49	interleukin 1 beta	Mus musculus	60-68
29747742-7	2018	RESULTS: The results showed that genistein exerted inhibitory effects on LPS-induced expressions of cyclooxygenase-2 (COX-2), inducible nitric oxide (iNOS), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6).	Genistein	33-42	interleukin 1 beta	Mus musculus	198-216
29445825-0	2018	Microglial IL-1beta progressively increases with duration of alcohol consumption.	Alcohols	61-68	interleukin 1 beta	Mus musculus	11-19
29445825-3	2018	Long-term alcohol consumption promotes the production of pro-inflammatory cytokines, such as TNF-alpha and IL-1beta, and activates microglia cells in the brain.	Alcohols	10-17	interleukin 1 beta	Mus musculus	107-115
29445825-7	2018	We found that alcohol drinking progressively enhanced IL-1beta expression in microglia, which was paralleled with an overall increased microglial density after long-term alcohol consumption.	Alcohols	14-21	interleukin 1 beta	Mus musculus	54-62
29629026-7	2018	In addition, vitamin C supplementation suppressed mRNA levels of pro-inflammatory mediators and cytokines, including cyclooxygenase-2, microsomal prostaglandin E synthase-2, tumor necrosis factor-alpha, Interleukin (IL)-1beta, and IL-6, and reduced expression of the proliferation marker, proliferating cell nuclear antigen, compared to observations of AOM/DSS animals.	Ascorbic Acid	13-22	interleukin 1 beta	Mus musculus	203-225
29747742-7	2018	RESULTS: The results showed that genistein exerted inhibitory effects on LPS-induced expressions of cyclooxygenase-2 (COX-2), inducible nitric oxide (iNOS), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6).	Genistein	33-42	interleukin 1 beta	Mus musculus	218-226
28661933-8	2018	At 20 h after CLP, PYR-41 treatment significantly decreased serum levels of proinflammatory cytokines (TNF-alpha, interleukin [IL]-1beta, and IL-6) and organ injury markers (aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase).	4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester	19-25	interleukin 1 beta	Mus musculus	127-136
28661933-11	2018	PYR-41 inhibited the expression of cytokines (IL-1beta and IL-6), chemokines (keratinocyte-derived chemokine and macrophage inflammatory protein 2), and inflammatory mediators (cyclooxygenase-2 and inducible nitric oxide synthase) in the lungs of septic mice.	4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester	0-6	interleukin 1 beta	Mus musculus	46-54
29496522-6	2018	DHT inhibited the myeloperoxidase (MPO) activity, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression in colon tissues and decreased serum levels of TNF-alpha, IL-1beta, IL-6, and high-mobility group box 1 (HMGB1).	Dihydrotestosterone	0-3	interleukin 1 beta	Mus musculus	187-195
29228376-13	2018	Most cytokines showed no treatment-related effects, but IL-1beta, IL-6, and IL-12 were slightly reduced in mice treated with DOX + CYP.	Doxorubicin	125-128	interleukin 1 beta	Mus musculus	56-64
29570626-3	2018	In the present work, we found that MES-13 cells, from a cell line derived from mesangial cells, stimulated with angiotensin II (AngII) developed oxidative stress (OS, thiobarbituric acid reactive species (TBARS) and generated pro-inflammatory cytokines (ELISA; IL-1beta and TNF-alpha).	2-(N-morpholino)ethanesulfonic acid	35-38	interleukin 1 beta	Mus musculus	261-269
29589594-5	2018	Mercaptoethanol treatment reduced the expression levels of NFE2L2, NF-kappaB, p65, TNF-alpha, IL-1beta and increased the expression levels of SOD1, MMP9, and GCLC.	Mercaptoethanol	0-15	interleukin 1 beta	Mus musculus	94-102
29458014-4	2018	Subsequently l-theanine ameliorated TPA-induced erythema, vascular permeability increase, epidermal and dermal hyperplasia, neutrophil infiltration and activation via downregulating the expression of PECAM-1 (a platelet endothelial adhesion molecule-1) in blood vessels and the production of pro-inflammatory cytokines IL-1beta, TNF-alpha, and mediator cyclooxygenase-2 (COX-2), which is mainly expressed in neutrophils.	theanine	13-23	interleukin 1 beta	Mus musculus	319-327
29458014-4	2018	Subsequently l-theanine ameliorated TPA-induced erythema, vascular permeability increase, epidermal and dermal hyperplasia, neutrophil infiltration and activation via downregulating the expression of PECAM-1 (a platelet endothelial adhesion molecule-1) in blood vessels and the production of pro-inflammatory cytokines IL-1beta, TNF-alpha, and mediator cyclooxygenase-2 (COX-2), which is mainly expressed in neutrophils.	Tetradecanoylphorbol Acetate	36-39	interleukin 1 beta	Mus musculus	319-327
30023835-5	2018	The results showed that blood glucose levels and IL-1beta levels in the GABA-CS NP-administered group were both significantly lower, whereas the PDX1 expression was significantly higher than that of the impaired group (p &lt; 0.01).	gaba-cs	72-79	interleukin 1 beta	Mus musculus	49-57
29587798-6	2018	TC-2559, a full agonist for alpha4beta2 nAChR, suppressed the upregulation of interleukin-1beta (IL-1beta) in the injured SCN after PSL and attenuated lipopolysaccharide-induced upregulation of IL-1beta in cultured macrophages.	TC 2559	0-7	interleukin 1 beta	Mus musculus	78-95
29587798-6	2018	TC-2559, a full agonist for alpha4beta2 nAChR, suppressed the upregulation of interleukin-1beta (IL-1beta) in the injured SCN after PSL and attenuated lipopolysaccharide-induced upregulation of IL-1beta in cultured macrophages.	TC 2559	0-7	interleukin 1 beta	Mus musculus	97-105
29587798-6	2018	TC-2559, a full agonist for alpha4beta2 nAChR, suppressed the upregulation of interleukin-1beta (IL-1beta) in the injured SCN after PSL and attenuated lipopolysaccharide-induced upregulation of IL-1beta in cultured macrophages.	TC 2559	0-7	interleukin 1 beta	Mus musculus	194-202
29587798-14	2018	administration of TC-2559 significantly suppressed morphological activation of Iba1+ microglia and decreased the upregulation of inflammatory microglia-dominant molecules, such as CD68, interferon regulatory factor 5, and IL-1beta in the SDH after PSL.	TC 2559	18-25	interleukin 1 beta	Mus musculus	222-230
29587798-14	2018	administration of TC-2559 significantly suppressed morphological activation of Iba1+ microglia and decreased the upregulation of inflammatory microglia-dominant molecules, such as CD68, interferon regulatory factor 5, and IL-1beta in the SDH after PSL.	sdh	238-241	interleukin 1 beta	Mus musculus	222-230
29467356-8	2018	CONCLUSIONS: These results suggest that endogenous IL-1beta is implicated in the progression of IPH via the inhibition of physiological angiogenesis in the atherosclerotic plaque, leading to the formation of leaky neovessels.	iph	96-99	interleukin 1 beta	Mus musculus	51-59
29743981-7	2018	Heme administration into C57BL/6 mice induced caspase-1 activation and cleavage of IL-1beta which was not observed in NLRP3-/- mice.	Heme	0-4	interleukin 1 beta	Mus musculus	83-91
29538417-6	2018	In addition, BB markedly attenuated colonic inflammation by alleviating inflammatory cell infiltration and inhibiting myeloperoxidase (MPO) and cytokines (TNF-alpha, IFN-gamma, IL-1beta, IL-6, IL-4 and IL-10) productions in DSS mice.	berberrubine	13-15	interleukin 1 beta	Mus musculus	177-185
29157127-5	2018	Metformin treatment decreased the expression of IL-1beta and IL-6 in epididymal fat, which was correlated with the abundance of various bacterial genera.	Metformin	0-9	interleukin 1 beta	Mus musculus	48-56
29040401-8	2018	With the same comparison, the positive cells of TUNEL staining and the expression of IL-6 and IL-1beta were significantly reduced, whereas the total/cleaved caspase-3 and total/pNF-kappaB were significantly increased in the O-HP group.	2-hydroxyphenylacetic acid	224-228	interleukin 1 beta	Mus musculus	94-102
29534526-9	2018	In BV-2 cells, peiminine significantly decreased LPS-induced expression of the pro-inflammatory mediators TNF-alpha, IL-6 and IL-1beta, COX-2 and iNOS by inhibiting the phosphorylation of ERK1/2, AKT and NF-kappaB p65.	peiminine	15-24	interleukin 1 beta	Mus musculus	126-134
29556199-5	2018	Consistently, DGLHD downregulated levels of ALT (alanine transaminase) and AST (aspartate transaminase), reduced production of proinflammatory cytokines-TNF (tumor necrosis factor) -alpha and IL (Interleukin) -1beta in serum and liver from mice with hepatic fibrosis, and inhibited hepatic stellate cell (HSC)-T6 cells proliferation.	dglhd	14-19	interleukin 1 beta	Mus musculus	192-215
29541444-4	2018	We found that, in PSGL-1+/+ mice, high salt diet resulted in high blood pressure with the increased expression of serum inflammatory cytokines IL-6, IL-1beta and TNFalpha, vascular injury markers MCP-1, ET-1, and VWF, and renal macrophages and T cells infiltration, and endothelium-dependent acetylcholine vasodilation dysfunction.	Salts	39-43	interleukin 1 beta	Mus musculus	149-157
28960086-8	2018	In the mothers" lungs, e-cigarette exposure with and without nicotine increased the proinflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	Nicotine	61-69	interleukin 1 beta	Mus musculus	110-118
29462849-5	2018	In BV2 microglial cells, 3",4"-dihydroxyflavone successfully inhibited production of chemokines such as nitric oxide and prostaglandin E2 and proinflammatory cytokines such as tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 in BV2 microglia.	3',4'-dihydroxyflavone	25-47	interleukin 1 beta	Mus musculus	205-223
29484750-6	2018	Costunolide treatment attenuated the main components of the fibrovascular tissue, wet weight, vascularization (Hb content), macrophage recruitment (NAG activity), collagen deposition, and the levels of vascular endothelial growth factor (VEGF), interleukin (IL)-1beta, IL-6, IL-17, tumor necrosis factor (TNF)-alpha and transforming growth factor (TGF-beta).	costunolide	0-11	interleukin 1 beta	Mus musculus	245-267
28990289-6	2018	The levels of two inflammatory factors, interleukin (IL)-1beta and inducible nitric oxide synthase, in dura mater were increased by NTG treatment, while the increase was attenuated by application of VP.	Nitroglycerin	132-135	interleukin 1 beta	Mus musculus	40-62
28926719-6	2018	The results show significant increase in the expression of caspase-1, IL-1beta, and IL-18 following treatment with Dox, which was inhibited by ES-exos but not mouse embryonic fibroblast exosomes.	Doxorubicin	115-118	interleukin 1 beta	Mus musculus	70-78
29426772-4	2018	The results demonstrated that violacin A attenuated the production of NO, IL-1beta, IL-6, and TNF-alpha as well as inhibited the expression of iNOS in LPS-induced RAW 264.7 cells.	violacin A	30-40	interleukin 1 beta	Mus musculus	74-82
28969938-8	2018	RESULTS: In mice treated with high-dose GW0742, plasma levels of IL-6, IL-1beta, and MCP-1 were significantly increased compared to the control group mice.	GW0742	40-46	interleukin 1 beta	Mus musculus	71-79
29291393-8	2018	PA treatment alleviated BBB dysfunction, inhibited mRNA and protein levels of TNF-alpha and IL-1beta and modulated the activation of MAPKs signaling pathways.	patchouli alcohol	0-2	interleukin 1 beta	Mus musculus	92-100
29325995-6	2018	In addition, AS also ameliorated the oxidative stress and neuroinflammation induced by d-gal through decreasing the level of interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), malondialdehyde (MDA) and enhancing the activity of the antioxidant enzymes superoxide dismutase (SOD).	Galactose	87-92	interleukin 1 beta	Mus musculus	125-142
29395778-7	2018	Moreover, a single injection of ethanol (2 g/kg) significantly increased microglial activation in the nucleus accumbens and microglial expression of the proinflammatory cytokine IL-1beta in TBI, but not sham or minocycline-treated, mice.	Ethanol	32-39	interleukin 1 beta	Mus musculus	178-186
29576052-2	2018	Norisoboldine (NOR), an alkaloid isolated from Radix Linderae, has previously been demonstrated to inhibit inflammation and IL-1beta production.	norisoboldine	0-13	interleukin 1 beta	Mus musculus	124-132
28969938-9	2018	When compared to mice treated with low-dose GW0742 plasma levels of IL-6, IL-1beta, GM-CSF, KC, and MCP-1 were significantly elevated in high-dose-treated mice.	GW0742	44-50	interleukin 1 beta	Mus musculus	74-82
29393707-10	2018	Kaempferol pretreatment showed reduction in cytokines IL-6, IL-1beta, and TNF-alpha in plasma as well as in lung tissue in comparison with septic mice without pretreatment.	kaempferol	0-10	interleukin 1 beta	Mus musculus	60-68
29275159-7	2018	Furthermore, COS effectively inhibited the levels of pro-inflammatory cytokines such as TNF-alpha, IL-1beta and IL-6, and markedly improved the activities of antioxidant enzymes (SOD, GSH-Px, CAT), as well as the content of skin hydroxyproline and moisture.	carbonyl sulfide	13-16	interleukin 1 beta	Mus musculus	99-107
29034546-13	2018	Intraplantar injection of the conditioned medium of ESC treated with IL-1beta and BK significantly induced licking behaviour, which was suppressed with BQ-123, an endothelin type-A receptor antagonist.	cyclo(Trp-Asp-Pro-Val-Leu)	152-158	interleukin 1 beta	Mus musculus	69-77
29485160-5	2018	And HKTP also could reduce the TNF-alpha, IL-1beta (interleukin-1 beta), and IL-6 mRNA expression in gastric injury mice.	hktp	4-8	interleukin 1 beta	Mus musculus	42-50
29473075-0	2018	Monascin inhibits IL-1beta induced catabolism in mouse chondrocytes and ameliorates murine osteoarthritis.	monascin	0-8	interleukin 1 beta	Mus musculus	18-26
29473075-5	2018	In vitro, monascin treatment inhibited the IL-1beta-induced expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6).	monascin	10-18	interleukin 1 beta	Mus musculus	43-51
29473075-5	2018	In vitro, monascin treatment inhibited the IL-1beta-induced expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6).	Nitric Oxide	110-122	interleukin 1 beta	Mus musculus	43-51
29473075-5	2018	In vitro, monascin treatment inhibited the IL-1beta-induced expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6).	Dinoprostone	159-175	interleukin 1 beta	Mus musculus	43-51
29485160-5	2018	And HKTP also could reduce the TNF-alpha, IL-1beta (interleukin-1 beta), and IL-6 mRNA expression in gastric injury mice.	hktp	4-8	interleukin 1 beta	Mus musculus	52-70
29473075-5	2018	In vitro, monascin treatment inhibited the IL-1beta-induced expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6).	Dinoprostone	177-181	interleukin 1 beta	Mus musculus	43-51
29428410-8	2018	Mechanistic studies showed that these inhibitors could release Nrf2 in H9c2 cells and LPS-inflammatory mouse models and translocate into the nucleus in a dose-response manner, which significantly increased the downstream genes (HO-1, NQO-1) and the pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), while ROS production dramatically decreased.	ros	311-314	interleukin 1 beta	Mus musculus	288-296
29473075-7	2018	Mechanistically, we revealed that monascin suppressed nuclear factor kappa B (NF-kappaB) signalling by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in IL-1beta-induced chondrocytes.	monascin	34-42	interleukin 1 beta	Mus musculus	172-180
29371164-5	2018	Thus, Avns reduced IKKbeta kinase activity in response to tert-butyl hydroperoxide (tBHP) stimulation and attenuated tBHP-induced TNFalpha and IL-1beta mRNA expression.	tert-Butylhydroperoxide	117-121	interleukin 1 beta	Mus musculus	143-151
28144715-11	2018	The attenuation of cardiac depression in irbesartan-treated mice was associated with lower levels of MCP-1 in plasma and a reduction in the levels of TNF-alpha, IL-1beta, and IL-6.	Irbesartan	41-51	interleukin 1 beta	Mus musculus	161-169
29155481-7	2018	The RGZ reduced leukocyte infiltration, preserved tissue structure, and dampened the 5-FU-induced expression of p53 and matrix metalloproteinase (Mmp)-2 after 5 days, and of Mmp-2 and interleukin (Il-1beta after 15 days.	Fluorouracil	85-89	interleukin 1 beta	Mus musculus	197-205
29193293-7	2018	CYM5442 treatment during the brief cuprizone exposure significantly prevented Il-1beta, Il-6, Cxcl10, and Cxcl3 induction, resulting in suppression of subsequent reactive gliosis and demyelination.	2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino)ethanol	0-7	interleukin 1 beta	Mus musculus	78-86
29198013-5	2018	Compared with the CLP + vehicle group, we found that early melatonin treatment resulted in increased survival rate but not improvement in measures of neurobehavioral outcomes, which was accompanied by significantly lower plasma level of IL-1beta.	Melatonin	59-68	interleukin 1 beta	Mus musculus	237-245
29204872-5	2018	ELISA and qPCR results indicated that RA dose-dependently decreased the expression of TNF-alpha, IL-1beta, and IL-6 both in tissues and mMECs.	rosmarinic acid	38-40	interleukin 1 beta	Mus musculus	97-105
29129634-3	2018	Further study show that beta-chitosan sulfate significantly promoted the production of NO, prostaglandin E2, tumor necrosis factor (TNF)-alpha, interleukin-6 and interleukin-1beta at the levels of transcription and translation.	beta-chitosan sulfate	24-45	interleukin 1 beta	Mus musculus	162-179
29234949-3	2018	Curc-mPEG454 showed lower cytotoxicity (IC50 57.8 muM) when compared with that of curcumin (IC50 32.6 muM) and inhibited the release of the inflammatory cytokines IL-6, TNF-alpha, IL-1beta, and MCP-1 in a concentration-dependent manner.	curc-mpeg454	0-12	interleukin 1 beta	Mus musculus	180-188
28993090-11	2018	TAC-induced protein overexpression of monocyte chemoattractant protein-1, and mRNA overexpression of tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 in the left atrium was suppressed by RVX treatment.	Rivaroxaban	199-202	interleukin 1 beta	Mus musculus	130-152
29367091-9	2018	Our data revealed that LPS induced the up-regulation of TNF-alpha, IL-1beta, iNOS and NF-kappaB p65, the down-regulation of PPAR-gamma were substantially suppressed by chrysophanol in RAW264.7 cells.	chrysophanic acid	168-180	interleukin 1 beta	Mus musculus	67-75
29328945-8	2018	RESULTS: Astaxanthin administration markedly reduced serum digestive enzyme activities, pancreatic histological scores, proinflammatory cytokine levels (tumor necrosis factor-alpha (TNF-alpha), Interleukin-1beta (IL-1beta), and Interleukin-6 (IL-6)), MPO and JAK/STAT3 activity.	astaxanthine	9-20	interleukin 1 beta	Mus musculus	194-211
29328945-8	2018	RESULTS: Astaxanthin administration markedly reduced serum digestive enzyme activities, pancreatic histological scores, proinflammatory cytokine levels (tumor necrosis factor-alpha (TNF-alpha), Interleukin-1beta (IL-1beta), and Interleukin-6 (IL-6)), MPO and JAK/STAT3 activity.	astaxanthine	9-20	interleukin 1 beta	Mus musculus	213-221
29328946-5	2018	The results showed that kaempferol reduced the production of various pro-inflammatory factors and inflammatory proteins including IL-1beta, IL-6, TNF-alpha, MCP-1, COX-2 and iNOS in brain tissues.	kaempferol	24-34	interleukin 1 beta	Mus musculus	130-138
31938266-8	2018	These results suggest that decreased estrogen level may accelerate degeneration of the cartilage endplate by increasing calcification, which may be induced by IL-1beta, in a dose-dependent manner.	Estrogens	37-45	interleukin 1 beta	Mus musculus	159-167
28352062-0	2018	Atorvastatin inhibits osteoclast differentiation by suppressing NF-kappaB and MAPK signaling during IL-1beta-induced osteoclastogenesis.	Atorvastatin	0-12	interleukin 1 beta	Mus musculus	100-108
29197723-10	2018	The protective analgesic and anti-inflammatory mechanisms of quercetin included the inhibition of TiO2-induced neutrophil and macrophage recruitment, proteoglycan degradation, oxidative stress, cytokine production (TNF-alpha, IL-1beta, IL-6, and IL-10), COX-2 mRNA expression, and bone resorption as well as activation of Nrf2/HO-1 signaling pathway.	Quercetin	61-70	interleukin 1 beta	Mus musculus	226-234
29355546-6	2018	In addition, magnolol restrained the expression of TNF-alpha, IL-1beta and IL-12 via the regulation of nuclear factor-kappaB (NF-kappaB) and Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) pathways.	magnolol	13-21	interleukin 1 beta	Mus musculus	62-70
29328461-6	2018	The tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6 and IL-18 concentrations, and caspase-3 and caspase-9 were significantly inhibited by gambogic acid in arthritic mice.	gambogic acid	154-167	interleukin 1 beta	Mus musculus	39-61
29369796-7	2018	The results showed that LPS-induced inflammatory mediators TNF-alpha, IL-1beta, NO, and PGE2 were significantly inhibited by asiatic acid.	asiatic acid	125-137	interleukin 1 beta	Mus musculus	70-78
28589946-4	2018	Using a murine bone marrow transplant (BMT) model, we show that overexpression of prostaglandin E2 (PGE2) post-BMT signals via EP2 or EP4 to induce cyclic adenosine monophosphate (cAMP), which activates protein kinase A or the exchange protein activated by cAMP (Epac) to induce cAMP response element binding-dependent transcription of IL-1beta leading to exacerbated lung injury in BMT mice.	Dinoprostone	82-98	interleukin 1 beta	Mus musculus	336-344
28589946-4	2018	Using a murine bone marrow transplant (BMT) model, we show that overexpression of prostaglandin E2 (PGE2) post-BMT signals via EP2 or EP4 to induce cyclic adenosine monophosphate (cAMP), which activates protein kinase A or the exchange protein activated by cAMP (Epac) to induce cAMP response element binding-dependent transcription of IL-1beta leading to exacerbated lung injury in BMT mice.	Dinoprostone	100-104	interleukin 1 beta	Mus musculus	336-344
28589946-4	2018	Using a murine bone marrow transplant (BMT) model, we show that overexpression of prostaglandin E2 (PGE2) post-BMT signals via EP2 or EP4 to induce cyclic adenosine monophosphate (cAMP), which activates protein kinase A or the exchange protein activated by cAMP (Epac) to induce cAMP response element binding-dependent transcription of IL-1beta leading to exacerbated lung injury in BMT mice.	Cyclic AMP	148-178	interleukin 1 beta	Mus musculus	336-344
28589946-5	2018	Induction of IL-1beta by PGE2 is time and dose dependent.	Dinoprostone	25-29	interleukin 1 beta	Mus musculus	13-21
29280507-4	2018	The results showed that injection of SO-GS-R significantly increased the levels of IL-1beta, IL-5, IL-6, G-CSF, KC, MCP-1, MIP-1alpha, and MIP-1beta in both serum and muscle.	sulfur monoxide	37-39	interleukin 1 beta	Mus musculus	83-91
28589946-8	2018	Reducing PGE2 levels with indomethacin improved bacterial clearance and reduced IL-1beta-mediated acute lung injury in P. aeruginosa-infected BMT mice.	Dinoprostone	9-13	interleukin 1 beta	Mus musculus	80-88
28589946-8	2018	Reducing PGE2 levels with indomethacin improved bacterial clearance and reduced IL-1beta-mediated acute lung injury in P. aeruginosa-infected BMT mice.	Indomethacin	26-38	interleukin 1 beta	Mus musculus	80-88
29737062-5	2018	CONCLUSION: The mechanism of sodium ferulate attenuated oxidative stress induced inflammation may be through blunting p38 MAPK signal pathway,the expression of NALP3 inflammasome,Caspase-1 and the secretion of IL-1beta are reduced.	ferulic acid	29-44	interleukin 1 beta	Mus musculus	210-218
29519319-10	2018	Further investigation implied that luteolin and luteolin-4"-O-glucoside improved the symptoms of inflammation by decreasing the levels of IL-1beta and TNF-alpha.	Luteolin	35-43	interleukin 1 beta	Mus musculus	138-146
29519319-10	2018	Further investigation implied that luteolin and luteolin-4"-O-glucoside improved the symptoms of inflammation by decreasing the levels of IL-1beta and TNF-alpha.	luteolin 4'-O-glucoside	48-71	interleukin 1 beta	Mus musculus	138-146
29344655-10	2018	The results demonstrated that the secretion of the inflammatory cytokines TNF-alpha, IL-6 and IL-1beta by LPS-stimulated BV2 cells was significantly reduced by osthole treatment.	osthol	160-167	interleukin 1 beta	Mus musculus	94-102
29682158-9	2018	Meanwhile, HC treatment lowered the levels of the proinflammatory cytokines IL-1beta, IL-6, IL-17, and TNF-alpha induced by Dox.	Doxorubicin	124-127	interleukin 1 beta	Mus musculus	76-84
29439712-10	2018	In addition, trovafloxacin treatment significantly reduced mRNA levels of several pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha), which correlates with an overall reduction in the accumulation of inflammatory cell types (neutrophils, microglia/macrophages, and astroglia) at the injury zone.	trovafloxacin	13-26	interleukin 1 beta	Mus musculus	110-118
29256438-10	2018	The NW-Sr-CS coatings could modulate the polarization of macrophages towards the wound-healing M2 phenotype, reduce the mRNA expression levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and enhance anti-inflammatory cytokines (IL-1ra, IL-10).	Cesium	10-12	interleukin 1 beta	Mus musculus	185-193
29354820-4	2018	Asiatic acid reduced LPS-induced expression and secretion of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in BV2 cells.	asiatic acid	0-12	interleukin 1 beta	Mus musculus	136-153
29354820-4	2018	Asiatic acid reduced LPS-induced expression and secretion of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in BV2 cells.	asiatic acid	0-12	interleukin 1 beta	Mus musculus	155-163
29636842-6	2018	Furthermore, the expression levels of caspase-1, IL-1beta, and IL-18 in BMDMs were elevated after treatment with mitophagy inhibitor 3-MA.	3-methyladenine	133-137	interleukin 1 beta	Mus musculus	49-57
29467717-9	2018	As same as, the expressions of the extracellular signal-regulated kinase, nuclear factor kappaB, tumor necrosis factor-alpha, and interleukin-1beta were induced by METH, which were suppressed in Trx-1 TG mice.	Methamphetamine	164-168	interleukin 1 beta	Mus musculus	130-147
29269019-7	2018	Quantitative RT-PCR analyses demonstrated that rivaroxaban reduced the expression of inflammatory molecules (e.g., IL-1beta and TNF-alpha) in injured arteries at seven days after surgery (P&lt;0.05, respectively).	Rivaroxaban	47-58	interleukin 1 beta	Mus musculus	115-123
29269019-8	2018	In vitro experiments using mouse peritoneal macrophages demonstrated that FXa increased the expression of inflammatory molecules (e.g., IL-1beta and TNF-alpha), which was blocked in the presence of rivaroxaban (P&lt;0.05).	Rivaroxaban	198-209	interleukin 1 beta	Mus musculus	136-144
28499899-7	2018	Our results indicate that Modafinil pretreatment also decreased the IL-1beta gene upregulation caused by LPS in brain areas, which is possibly correlated with the preventive behavioral effects.	Modafinil	26-35	interleukin 1 beta	Mus musculus	68-76
29043426-6	2018	TCDD-induced hydronephrosis was more severe in wild-type fetuses than in cPLA2alpha-null fetuses regardless of sex, and kidney expression levels of the inflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha were increased in a cPLA2alpha-dependent manner in TCDD-exposed fetuses.	Polychlorinated Dibenzodioxins	0-4	interleukin 1 beta	Mus musculus	175-224
29043426-6	2018	TCDD-induced hydronephrosis was more severe in wild-type fetuses than in cPLA2alpha-null fetuses regardless of sex, and kidney expression levels of the inflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha were increased in a cPLA2alpha-dependent manner in TCDD-exposed fetuses.	Polychlorinated Dibenzodioxins	276-280	interleukin 1 beta	Mus musculus	175-224
29366788-7	2018	Thus, we show that IL-1R2 is harmful for the development of colitis, because IL-1R2 promotes the growth of proinflammatory intestinal microbiota by suppressing IL-1beta-induced AMP production.	Adenosine Monophosphate	177-180	interleukin 1 beta	Mus musculus	160-168
29497376-10	2018	In vitro, studies further revealed that quercetin efficiently inhibited macrophages activation and M1 polarization, as well as decreased the mRNA expression of M1 macrophage markers such as TNF-alpha, IL-1beta, IL-6, and nitric oxide synthase 2.	Quercetin	40-49	interleukin 1 beta	Mus musculus	201-209
29415054-9	2018	Compared to ALI alone, COS treatment of ALI caused a significant decrease in the wet/dry lung weight ratio, indicating a reduction in lung edema, inflammatory cell infiltration, levels of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-4, IL-6 and nuclear factor kappa B mRNA and protein expression were reduced and IL-10 mRNA and protein expression was increased (P &lt; 0.05).	carbonyl sulfide	23-26	interleukin 1 beta	Mus musculus	217-239
29445415-0	2018	Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1beta.	Curcumin	0-8	interleukin 1 beta	Mus musculus	101-118
29445415-0	2018	Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1beta.	piperine	13-21	interleukin 1 beta	Mus musculus	101-118
29445415-8	2018	Results: Compared to the other groups, obese mice who underwent CR and received Cur + Pip in their diet lost more fat and had significantly lower IL-1beta and KC/GRO.	piperine	86-89	interleukin 1 beta	Mus musculus	146-154
29445415-10	2018	However, plasma IL-1beta levels were inversely correlated with curcumin glucuronide.	curcumin glucuronide	63-83	interleukin 1 beta	Mus musculus	16-24
29051087-7	2018	Additionally, mRNA levels of inflammation related molecules including IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha, inducible nitric oxide synthase (iNOS) and CD16, were increased after cisplatin treatment.	Cisplatin	191-200	interleukin 1 beta	Mus musculus	70-78
29081070-10	2018	Interestingly, the administration of paeoniflorin blocked the maturation of interleukin-1beta, which is a critical substrate of MMPs.	peoniflorin	37-49	interleukin 1 beta	Mus musculus	76-93
29030662-8	2018	Oral givinostat monotherapy did not reverse established diabetes but reduced the in situ production of inflammatory cytokines (IL-1beta, IL-6, TNF-alpha).	givinostat	5-15	interleukin 1 beta	Mus musculus	127-135
29081070-14	2018	SIGNIFICANCE: Our results provided direct evidence for the first time that paeoniflorin can inhibit plantar incision-induced microglia TLR4/MMP-9/2/IL-1beta signalling pathway and suppress postoperative pain.	peoniflorin	75-87	interleukin 1 beta	Mus musculus	148-156
29247486-7	2018	Caspase-1 and IL-1beta were activated in the skin of IMQ-treated HFD mice, and their serum level of IL-17A, TNF-alpha and IL-1beta was significantly upregulated.	Imiquimod	53-56	interleukin 1 beta	Mus musculus	14-22
28970254-4	2018	Phosphorylation of inositol-requiring enzyme (IRE)1alpha and eIF2alpha, expression of thioredoxin-interacting protein and cleaved caspase-1, and release of IL-1beta were reduced by silybin.	Inositol	19-27	interleukin 1 beta	Mus musculus	156-164
28970254-4	2018	Phosphorylation of inositol-requiring enzyme (IRE)1alpha and eIF2alpha, expression of thioredoxin-interacting protein and cleaved caspase-1, and release of IL-1beta were reduced by silybin.	Silybin	181-188	interleukin 1 beta	Mus musculus	156-164
28970254-8	2018	The anti-inflammatory effect of silybin was blocked by SIRT2 silencing or by the SIRT2 inhibitor AGK2, as evidenced by NLRP3/ASC colocalization, AC-alpha-tubulin expression, and IL-1beta release.	Silybin	32-39	interleukin 1 beta	Mus musculus	178-186
29247486-7	2018	Caspase-1 and IL-1beta were activated in the skin of IMQ-treated HFD mice, and their serum level of IL-17A, TNF-alpha and IL-1beta was significantly upregulated.	Imiquimod	53-56	interleukin 1 beta	Mus musculus	122-130
29027124-7	2018	In an experimental mouse model of GVHD, 5Z-7-oxozeaenol administration after allo-HCT ameliorated GVHD severity and mortality, with significant reduction in serum TNFalpha, IL-1beta, and IL-12 levels.	5-7-oxo-zeaenol	40-55	interleukin 1 beta	Mus musculus	173-181
29223854-5	2018	Further in vivo investigations revealed that the hepatoprotective activities of BA was due to the effects on remarkably suppressing the inflammatory cascade, including attenuating the expressions of HMGB1, TLR4, Myd88, NF-kappaB and IkappaB proteins and inhibiting the production of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha in diabetic mice.	baicalein	80-82	interleukin 1 beta	Mus musculus	283-305
29223854-8	2018	Inflammation condition was also recovered with BA treatment as shown by the changes of HMGB1, TLR4, Myd88, NF-kappaB and IkappaB expressions and the levels of IL-1beta, IL-6 and TNF-alpha.	baicalein	47-49	interleukin 1 beta	Mus musculus	159-167
29199487-7	2018	RESULTS AND DISCUSSION: Treatment with the major chalcone 1 significantly attenuated the production of NO and proinflammatory cytokines, tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 in a dose-dependent manner.	Chalcone	49-57	interleukin 1 beta	Mus musculus	166-183
29245072-9	2018	RESULTS: Phloretin pretreatment dramatically suppressed the mucins secretion, inflammatory cell infiltration and inflammatory cytokine release in mouse lungs induced by CS, and it also suppressed CSE-induced expression of MUC5AC and IL-1beta in NCI-H292 bronchial epithelial cells.	Phloretin	9-18	interleukin 1 beta	Mus musculus	233-241
29207013-0	2018	Effects of kartogenin on the attenuated nucleus pulposus cell degeneration of intervertebral discs induced by interleukin-1beta and tumor necrosis factor-alpha.	kartogenin	11-21	interleukin 1 beta	Mus musculus	110-127
29636837-5	2018	The treatment with Zingerone significantly attenuated the levels of IL-1beta, IL-2, and TNFalpha in group 3 compared to group 2.	zingerone	19-28	interleukin 1 beta	Mus musculus	68-76
28771872-5	2018	Atorvastatin also inhibited the expression of inflammatory factors IL-1beta and TNFalpha induced by LPS in RAW264.7 cells.	Atorvastatin	0-12	interleukin 1 beta	Mus musculus	67-75
28771872-6	2018	Furthermore, pretreatment with an autophagy inhibitor 3MA or LY294002 attenuated the suppressive effect of atorvastatin on LPS-induced IL-1beta and TNFalpha expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	interleukin 1 beta	Mus musculus	135-143
28771872-6	2018	Furthermore, pretreatment with an autophagy inhibitor 3MA or LY294002 attenuated the suppressive effect of atorvastatin on LPS-induced IL-1beta and TNFalpha expression.	Atorvastatin	107-119	interleukin 1 beta	Mus musculus	135-143
28771872-7	2018	Additionally, knockdown autophagy-related gene 5(Atg5) with a special siRNA also prevented the role of atorvastatin in decreasing IL-1beta and TNFalpha release induced by LPS.	Atorvastatin	103-115	interleukin 1 beta	Mus musculus	130-138
29131494-5	2018	Meanwhile, GML significantly changed the beta-diversity and composition of gut microbiota and upregulated the circulating levels of serum LPS, IL-1beta, IL-6, and TNF-alpha.	monolaurin	11-14	interleukin 1 beta	Mus musculus	143-151
29307174-5	2018	ELISA results revealed that DHA could enhance the protein expression of cytokines IL-1beta, IL-6, IL-10, IL-12, TNF-alpha, IFN-gamma, and TGF-beta.	Docosahexaenoic Acids	28-31	interleukin 1 beta	Mus musculus	82-90
29378573-6	2018	Moreover, cortisol inhibited the mRNA expression of pro-inflammatory cytokines including tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) and decreased IL-1beta secretion in an LPS-treated RAW264.7 macrophage cell line.	Hydrocortisone	10-18	interleukin 1 beta	Mus musculus	129-146
29378573-6	2018	Moreover, cortisol inhibited the mRNA expression of pro-inflammatory cytokines including tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) and decreased IL-1beta secretion in an LPS-treated RAW264.7 macrophage cell line.	Hydrocortisone	10-18	interleukin 1 beta	Mus musculus	148-156
29378573-6	2018	Moreover, cortisol inhibited the mRNA expression of pro-inflammatory cytokines including tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) and decreased IL-1beta secretion in an LPS-treated RAW264.7 macrophage cell line.	Hydrocortisone	10-18	interleukin 1 beta	Mus musculus	198-206
29399292-4	2018	RESULTS: Following stimulation of BV2 cells by LPS, exposure to BCE significantly reduced the generation of nitric oxide as well as mRNA levels of numerous inflammatory factors such as inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), interleukin 1 beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha).	Nitric Oxide	108-120	interleukin 1 beta	Mus musculus	251-269
29399292-4	2018	RESULTS: Following stimulation of BV2 cells by LPS, exposure to BCE significantly reduced the generation of nitric oxide as well as mRNA levels of numerous inflammatory factors such as inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), interleukin 1 beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha).	Nitric Oxide	108-120	interleukin 1 beta	Mus musculus	271-279
29552299-3	2018	Results: The tulobuterol patch significantly ameliorated inflammatory cell infiltration in the lung tissue, reduced the number of total leukocytes and its differential count, markedly reduced the production of IL-1beta, TNF-alpha, IL-6, CCL-11 and IL-4 in bronchial alveolar lavage fluid, as well as a reduction in IL-4/IFN-gamma ratio.	tulobuterol	13-24	interleukin 1 beta	Mus musculus	210-218
29374192-7	2018	Wound macrophages from CSO-treated group displayed increased production of anti-inflammatory cytokines IL-10 and TGF-beta, and decreased levels of pro-inflammatory cytokines TNF-alpha and IL-1beta.	CSO	23-26	interleukin 1 beta	Mus musculus	188-196
28961808-8	2018	In vivo, oral administration of NPs-PEG-FA/6-shogaol encapsulated in a hydrogel system [chitosan/alginate] significantly alleviated colitis symptoms and accelerated colitis wound repair in DSS-treated mice by regulating the expression levels of pro-inflammatory [TNF-alpha, IL-6, IL-1beta, and iNOS] and anti-inflammatory [Nrf-2 and HO-1] factors.	peg-fa	36-42	interleukin 1 beta	Mus musculus	280-288
28961808-8	2018	In vivo, oral administration of NPs-PEG-FA/6-shogaol encapsulated in a hydrogel system [chitosan/alginate] significantly alleviated colitis symptoms and accelerated colitis wound repair in DSS-treated mice by regulating the expression levels of pro-inflammatory [TNF-alpha, IL-6, IL-1beta, and iNOS] and anti-inflammatory [Nrf-2 and HO-1] factors.	shogaol	43-52	interleukin 1 beta	Mus musculus	280-288
29403490-0	2018	Corticosterone Preexposure Increases NF-kappaB Translocation and Sensitizes IL-1beta Responses in BV2 Microglia-Like Cells.	Corticosterone	0-14	interleukin 1 beta	Mus musculus	76-84
28961808-8	2018	In vivo, oral administration of NPs-PEG-FA/6-shogaol encapsulated in a hydrogel system [chitosan/alginate] significantly alleviated colitis symptoms and accelerated colitis wound repair in DSS-treated mice by regulating the expression levels of pro-inflammatory [TNF-alpha, IL-6, IL-1beta, and iNOS] and anti-inflammatory [Nrf-2 and HO-1] factors.	Chitosan	88-96	interleukin 1 beta	Mus musculus	280-288
28961808-8	2018	In vivo, oral administration of NPs-PEG-FA/6-shogaol encapsulated in a hydrogel system [chitosan/alginate] significantly alleviated colitis symptoms and accelerated colitis wound repair in DSS-treated mice by regulating the expression levels of pro-inflammatory [TNF-alpha, IL-6, IL-1beta, and iNOS] and anti-inflammatory [Nrf-2 and HO-1] factors.	Alginates	97-105	interleukin 1 beta	Mus musculus	280-288
29269298-9	2018	RESULTS: Dexmedetomidine at 20 mug/kg significantly attenuated pancreatic pathological injury, reduced serum levels of amylase, lipase, IL-1beta, IL-6, and tumor necrosis factor (TNF)-alpha, and decreased the expression of MPO in pancreatic tissue in both mouse models of pancreatitis.	Dexmedetomidine	9-24	interleukin 1 beta	Mus musculus	136-144
29269298-10	2018	In addition, dexmedetomidine at 20 mug/kg significantly down-regulated the expression of NLRP3, pro-IL-1beta, and IL-1beta in pancreatic tissue, but up-regulated the expression of NET in both mouse models.	Dexmedetomidine	13-28	interleukin 1 beta	Mus musculus	100-108
29269298-10	2018	In addition, dexmedetomidine at 20 mug/kg significantly down-regulated the expression of NLRP3, pro-IL-1beta, and IL-1beta in pancreatic tissue, but up-regulated the expression of NET in both mouse models.	Dexmedetomidine	13-28	interleukin 1 beta	Mus musculus	114-122
29275229-1	2018	Reactive oxygen species (ROS) are key signaling molecules and their overproduction plays an important role in the inflammation process, the secretion of inflammatory cytokines such as IL-1beta and IL-6 and the progression of inflammatory disorders.	Reactive Oxygen Species	0-23	interleukin 1 beta	Mus musculus	184-192
29275229-1	2018	Reactive oxygen species (ROS) are key signaling molecules and their overproduction plays an important role in the inflammation process, the secretion of inflammatory cytokines such as IL-1beta and IL-6 and the progression of inflammatory disorders.	Reactive Oxygen Species	25-28	interleukin 1 beta	Mus musculus	184-192
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	interleukin 1 beta	Mus musculus	29-46
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	interleukin 1 beta	Mus musculus	48-56
29224353-4	2018	Curcumin also reduced aortic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression, nuclear factor-kappaB (NF-kappaB) activity, and plasma IL-1beta, TNF-alpha, soluble VCAM-1 and ICAM-1 levels.	Curcumin	0-8	interleukin 1 beta	Mus musculus	257-265
29423011-8	2018	Increased production of ROS and expression of NLRP3, ASC, caspase-1, IL-18 and IL-1beta proteins were observed in RAW264.7 cells incubated with LPS and were effectively inhibited by 2 muM luteolin.	Reactive Oxygen Species	24-27	interleukin 1 beta	Mus musculus	79-87
29069290-3	2018	Dietary celastrol (31.25 ppm in rodent diet from 8 weeks to 25 weeks of age) is well tolerated and protects against LPS-induced acute inflammation in C57BL/6 mice, potently suppressing LPS-induction of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, Interleukin (IL)-6 and IL-1beta.	celastrol	8-17	interleukin 1 beta	Mus musculus	289-297
29375379-7	2017	The results showed that scutellarin dose-dependently reduced caspase-1 activation and decreased mature interleukin-1beta (IL-1beta) release in lipopolysaccharide (LPS)-primed macrophages upon ATP or nigericin stimulation, indicating that scutellarin inhibited NLRP3 inflammasome activation in macrophages.	scutellarin	24-35	interleukin 1 beta	Mus musculus	103-120
29069290-6	2018	Celastrol chemoprevention of CAC in this new model of intestinal neoplasia was associated with significant suppression of iNOS at 4 months of age, and iNOS, COX-2 and NFkappaB at 6 months of age, with significant reduction in inflammatory cytokines, IL-6 and IL-1beta.	celastrol	0-9	interleukin 1 beta	Mus musculus	259-267
29328910-3	2018	Administration of beta-glucan (prototypical trained-immunity-inducing agonist) to mice induced expansion of progenitors of the myeloid lineage, which was associated with elevated signaling by innate immune mediators, such as IL-1beta and granulocyte-macrophage colony-stimulating factor (GM-CSF), and with adaptations in glucose metabolism and cholesterol biosynthesis.	beta-Glucans	18-29	interleukin 1 beta	Mus musculus	225-233
29375379-7	2017	The results showed that scutellarin dose-dependently reduced caspase-1 activation and decreased mature interleukin-1beta (IL-1beta) release in lipopolysaccharide (LPS)-primed macrophages upon ATP or nigericin stimulation, indicating that scutellarin inhibited NLRP3 inflammasome activation in macrophages.	scutellarin	24-35	interleukin 1 beta	Mus musculus	122-130
29375379-12	2017	As NLRP3-dependent release of IL-1beta has a critical role in sepsis, the in vivo activity of scutellarin was assayed in a mouse model of bacterial sepsis, which was established by intraperitoneally injection of a lethal dose of viable Escherichia coli.	scutellarin	94-105	interleukin 1 beta	Mus musculus	30-38
29375379-7	2017	The results showed that scutellarin dose-dependently reduced caspase-1 activation and decreased mature interleukin-1beta (IL-1beta) release in lipopolysaccharide (LPS)-primed macrophages upon ATP or nigericin stimulation, indicating that scutellarin inhibited NLRP3 inflammasome activation in macrophages.	Adenosine Triphosphate	192-195	interleukin 1 beta	Mus musculus	122-130
29375379-14	2017	In line with this, scutellarin treatment significantly reduced serum IL-1beta levels and attenuated the infiltration of inflammatory cells in the liver of E. coli-infected mice.	scutellarin	19-30	interleukin 1 beta	Mus musculus	69-77
29113806-3	2018	Ex vivo tests showed that Cynatratoside-C inhibited the expression of TLR4 and pro-inflammatory cytokine (TNF-alpha, IL-6 and IL-1beta) production in LPS-stimulated primary mouse mammary epithelial cells.	cynatratoside-C	26-41	interleukin 1 beta	Mus musculus	126-134
29507526-5	2018	In addition, the result showed that formononetin could reduce the NLRP3 pathway protein levels (NLRP3, ASC, IL-1beta) in vivo and vitro, and MCC950, the NLRP3 specific inhibitor, could alleviate the DSS-induced mice acute colitis.	formononetin	36-48	interleukin 1 beta	Mus musculus	108-116
29054324-5	2018	6-OHDA administration elevated levels of tumour necrosis factor-alpha, interferon-gamma, interleukin-1beta, interleukin-2, interleukin-6 and nuclear factor-kappa B and decreased the interleukin-10 levels, total reactive antioxidant potential and total antioxidant reactivity in striatum, as well as, modified the calcium-binding protein B (S100B), brain-derived neurotrophic factor, nerve growth factor and glial cell line-derived neurotrophic factor levels.	Oxidopamine	0-6	interleukin 1 beta	Mus musculus	89-106
29136951-8	2018	Further analysis showed that Myricetin strongly reduced the levels of inflammatory factors TNF-alpha, IL-1beta, IL-6, NF-kappaB, p-NF-kappaB, cyclooxygenase-2 (COX-2), PCNA and Cyclin D1 in the colonic tissues as analyzed by the assays of immunohistochemical staining, Western blotting and Q-RT-PCR.	myricetin	29-38	interleukin 1 beta	Mus musculus	102-110
28986310-10	2018	Administration of the NLRP3 inflammasome inhibitor MCC950 indicated that EMD638683 attenuated Ang II-induced cardiac inflammation and fibrosis by inhibiting the NLRP3 inflammasome/IL-1beta secretion axis.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	51-57	interleukin 1 beta	Mus musculus	180-188
29156532-6	2018	This was accompanied by the alleviating of inflammation and oxidative stress, such as decreased levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-6) interleukin-1beta (IL-1beta) and malondialdehyde (MDA) and increased levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) in serum and liver tissues.	Malondialdehyde	201-216	interleukin 1 beta	Mus musculus	187-195
30423565-10	2018	Consistent with the milder inflammatory pathological changes, DSS-treated KO mice had lower levels of IL-1beta, IL-6 and TNF-alpha mRNA in the liver and the colon.	Dextran Sulfate	62-65	interleukin 1 beta	Mus musculus	102-110
29156532-6	2018	This was accompanied by the alleviating of inflammation and oxidative stress, such as decreased levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-6) interleukin-1beta (IL-1beta) and malondialdehyde (MDA) and increased levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) in serum and liver tissues.	gsh-px	302-308	interleukin 1 beta	Mus musculus	187-195
30196290-10	2018	RESULTS: The expression of M3-mAChR was down-regulated in the myocardium from aged mice and D-galactose-treated mice, while the expression levels of caspase-1 and its downstream molecule IL-1beta were significantly increased.	Galactose	92-103	interleukin 1 beta	Mus musculus	187-195
29669987-8	2018	Further mechanistic insights demonstrated that chloroform up-regulated pro-inflammatory cytokine, IL-1beta, in the livers and blood, which was suppressed by 3-MA.	Chloroform	47-57	interleukin 1 beta	Mus musculus	98-106
29669987-8	2018	Further mechanistic insights demonstrated that chloroform up-regulated pro-inflammatory cytokine, IL-1beta, in the livers and blood, which was suppressed by 3-MA.	3-methyladenine	157-161	interleukin 1 beta	Mus musculus	98-106
30121673-8	2018	RESULTS: LIG lowered the phosphorylation levels of p65, IkappaBalpha, and IKKalpha/beta and suppressed the IL-1beta-induced expression of MMP-3, ADAMTS-5, iNOS, and COX-2 and the inflammatory factors PGE2, TNF-alpha, and IL-6.	Dinoprostone	200-204	interleukin 1 beta	Mus musculus	107-115
30448827-6	2018	RESULTS: Butyrate reduced the expression of canonic pro-inflammatory mediators (Nos2, COX-2, IL-6), pro-inflammatory adipokines (lipocalin-2 and nesfatin-1) and adhesion molecule (VCAM-1 and ICAM-1) in IL-1beta-stimulated chondrocytes, inhibiting several inflammatory signalling pathways (NFkappaB, MAPKinase, AMPK-alpha, PI3K/Akt).	Butyrates	9-17	interleukin 1 beta	Mus musculus	202-210
30448827-7	2018	Butyrate also reduced metalloproteinase production and limited the loss of type II collagen in IL-1beta-inflamed chondrocytes.	Butyrates	0-8	interleukin 1 beta	Mus musculus	95-103
29554661-6	2018	RESULTS: The contents of pro-inflammatory cytokines interleukin (IL)-1beta, IL-6 and tumour necrosis factor (TNF)-alpha were inhibited by ALK, metformin or fasudil in diabetic db/db mice.	Metformin	143-152	interleukin 1 beta	Mus musculus	52-74
29554661-6	2018	RESULTS: The contents of pro-inflammatory cytokines interleukin (IL)-1beta, IL-6 and tumour necrosis factor (TNF)-alpha were inhibited by ALK, metformin or fasudil in diabetic db/db mice.	fasudil	156-163	interleukin 1 beta	Mus musculus	52-74
28992480-9	2018	These findings uncovered a possible mechanism of intestinal mucosal innate immunity in response to mycotoxin ZEA that ZEA could activate the ROS-mediated NLRP3 inflammasome and, in turn, contribute to the caspase-1-dependent activation of the inflammatory cytokines IL-1beta and IL-18.	Zearalenone	109-112	interleukin 1 beta	Mus musculus	266-274
29794447-16	2018	LCA increased the expression of NLRP3, ASC, caspase-1, and IL-1beta genes and proteins in hepatic tissue.	Lithocholic Acid	0-3	interleukin 1 beta	Mus musculus	59-67
29794447-17	2018	The activities of IL-1beta and caspase-1 were increased in the LCA group.	Lithocholic Acid	63-66	interleukin 1 beta	Mus musculus	18-26
28992480-5	2018	However, ROS inhibitor N-acetyl-l-cysteine (NAC) reduced IL-1beta and IL-18 release to 45 pg mL-1 and 108 pg mL-1.	Reactive Oxygen Species	9-12	interleukin 1 beta	Mus musculus	57-65
28992480-9	2018	These findings uncovered a possible mechanism of intestinal mucosal innate immunity in response to mycotoxin ZEA that ZEA could activate the ROS-mediated NLRP3 inflammasome and, in turn, contribute to the caspase-1-dependent activation of the inflammatory cytokines IL-1beta and IL-18.	Reactive Oxygen Species	141-144	interleukin 1 beta	Mus musculus	266-274
28992480-5	2018	However, ROS inhibitor N-acetyl-l-cysteine (NAC) reduced IL-1beta and IL-18 release to 45 pg mL-1 and 108 pg mL-1.	Acetylcysteine	23-42	interleukin 1 beta	Mus musculus	57-65
28992480-5	2018	However, ROS inhibitor N-acetyl-l-cysteine (NAC) reduced IL-1beta and IL-18 release to 45 pg mL-1 and 108 pg mL-1.	Acetylcysteine	44-47	interleukin 1 beta	Mus musculus	57-65
29399089-8	2018	GA-A treatment reduced LPS-induced expression of nuclear factor (NF)-kappaB (p65) and its inhibitor, demonstrating that non-toxic suppression of IL-1beta, IL-6 and TNF-alpha production by GA-A is, at least in part, due to suppression of the NF-kappaB signaling pathway.	ganoderic acid A	188-192	interleukin 1 beta	Mus musculus	145-153
29732971-9	2018	Accordingly, cinnamic acid also increased the level of SOCS3 and suppressed the expression of inducible nitric oxide synthase and proinflammatory cytokines (TNFalpha, IL-1beta and IL-6) in LPSstimulated BV-2 microglial cells.	cinnamic acid	13-26	interleukin 1 beta	Mus musculus	167-175
29399089-7	2018	The results of the present study demonstrated that GA-A significantly decreased LPS-induced IL-1beta, IL-6 and TNF-alpha release from mouse-derived primary cortical microglial cells in a concentration-dependent manner.	ganoderic acid A	51-55	interleukin 1 beta	Mus musculus	92-100
28125915-6	2018	Furthermore, GalN/LPS increased nuclear factor kappa-B activation and the levels of tumor necrosis factor-alpha and interleukin-1beta.	Galactosamine	13-17	interleukin 1 beta	Mus musculus	116-133
29399089-8	2018	GA-A treatment reduced LPS-induced expression of nuclear factor (NF)-kappaB (p65) and its inhibitor, demonstrating that non-toxic suppression of IL-1beta, IL-6 and TNF-alpha production by GA-A is, at least in part, due to suppression of the NF-kappaB signaling pathway.	ganoderic acid A	0-4	interleukin 1 beta	Mus musculus	145-153
29202301-2	2018	beta-Glucan-induced dectin-1 signalling activates the NLRP3 inflammasome, which in turn rapidly produces IL-1beta, a master regulator of inflammation.	beta-Glucans	0-11	interleukin 1 beta	Mus musculus	105-113
29202301-5	2018	Furthermore, SYK inhibition markedly decreased beta-glucan-induced IL-1beta expression, suggesting that SYK is indispensable for NLRP3 inflammasome activation.	beta-Glucans	47-58	interleukin 1 beta	Mus musculus	67-75
29138800-5	2018	The present study investigated this belief and demonstrated that BM significantly inhibited the expression of interleukin-1beta (IL-1beta), IL-6, cyclooxygenase-2 and inducible nitric oxide synthase in RAW264.7 cells, but had little influence on the cell viability, cell cycle and apoptosis.	BM	65-67	interleukin 1 beta	Mus musculus	110-127
29138800-5	2018	The present study investigated this belief and demonstrated that BM significantly inhibited the expression of interleukin-1beta (IL-1beta), IL-6, cyclooxygenase-2 and inducible nitric oxide synthase in RAW264.7 cells, but had little influence on the cell viability, cell cycle and apoptosis.	BM	65-67	interleukin 1 beta	Mus musculus	129-137
28782172-3	2018	In vitro and ex vivo, biochemical and histological analysis demonstrated that 3"-sialyllactose was sufficient to restore the synthesis of Col2a1 and accumulation of sulphated proteoglycan, a critical factor for cartilage regeneration in osteoarthritic development, and blocked the expression of Mmp3, Mmp13 and Cox2 induced by IL-1beta, IL-6, IL-17 and TNF-alpha, which mediates cartilage degradation.	3'-sialyllactose	78-94	interleukin 1 beta	Mus musculus	327-335
28782172-5	2018	Additionally, IL-1beta induction of Erk phosphorylation and IkappaB degradation, representing a critical signal pathway for osteoarthritic development, was totally blocked by 3"-sialyllactose in a dose-dependent manner.	3'-sialyllactose	175-191	interleukin 1 beta	Mus musculus	14-22
29732438-7	2018	Comparisons of pro-inflammatory cytokine concentrations among central and peripheral metabolic tissues indicate that patterns of liver interleukin-1beta concentrations best reflects observed changes in glucose tolerance.	Glucose	202-209	interleukin 1 beta	Mus musculus	135-152
28982597-9	2018	Moreover, trans-astaxanthin at 80mg/kg was demonstrated to effectively antagonize IL-1beta, IL-6 and TNF-alpha expression in hippocampus and spinal cord of CCI mice.	astaxantin, calcium, citrus bioflavoid, lycopene, vitamin D3 drug combination	10-27	interleukin 1 beta	Mus musculus	82-90
29066299-4	2018	We found that the production of pro-inflammatory mediators, including interleukin-6(IL-6), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), induced by LPS was significantly suppressed by beta-elemene in a dose-dependent manner in RAW264.7 macrophage cell line.	beta-elemene	212-224	interleukin 1 beta	Mus musculus	135-152
29066299-4	2018	We found that the production of pro-inflammatory mediators, including interleukin-6(IL-6), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), induced by LPS was significantly suppressed by beta-elemene in a dose-dependent manner in RAW264.7 macrophage cell line.	beta-elemene	212-224	interleukin 1 beta	Mus musculus	154-162
29115385-4	2018	Furthermore, schisandrin A was demonstrated to reduce the LPS-induced secretion of pro-inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-1beta; this was accompanied by a simultaneous decrease in the respective mRNA and protein levels in the macrophages.	schizandrin A	13-26	interleukin 1 beta	Mus musculus	153-170
29553092-7	2018	Subcutaneous injection of aculeatiside A and naringin enhanced mRNA expression of IL-1beta, IL12, and CD169 in regional lymph nodes in mice.	Aculeatiside A	26-40	interleukin 1 beta	Mus musculus	82-90
29553092-7	2018	Subcutaneous injection of aculeatiside A and naringin enhanced mRNA expression of IL-1beta, IL12, and CD169 in regional lymph nodes in mice.	naringin	45-53	interleukin 1 beta	Mus musculus	82-90
29155303-0	2018	Therapeutic vaccine against IL-1beta improved glucose control in a mouse model of type 2 diabetes.	Glucose	46-53	interleukin 1 beta	Mus musculus	28-36
29158052-10	2018	BA treatment dramatically suppressed MCD diet-induced hepatic inflammation, which was associated with decrease in serum TNF-alpha, IL-1beta and MCP-1 production, macrophage influx and suppression of nuclear factor-kappaB activation.	baicalin	0-2	interleukin 1 beta	Mus musculus	131-139
29115547-7	2018	Hesperidin treatment caused a significant decrease in the levels of TNF-alpha, IL-1beta, IL-6, MCP-1, ICAM-1, MDA, CAT, SOD and caspase-3/9 in mice with AMI.	Hesperidin	0-10	interleukin 1 beta	Mus musculus	79-87
30380983-9	2018	Immunohistochemical staining revealed that THSG blocked the activation of microglia and reduced the release of proinflammatory cytokines TNF-alpha, interleukin 1beta (IL-1beta), and interleukin 6 (IL-6).	thsg	43-47	interleukin 1 beta	Mus musculus	148-165
30380983-9	2018	Immunohistochemical staining revealed that THSG blocked the activation of microglia and reduced the release of proinflammatory cytokines TNF-alpha, interleukin 1beta (IL-1beta), and interleukin 6 (IL-6).	thsg	43-47	interleukin 1 beta	Mus musculus	167-175
28943285-10	2018	Furthermore, ethanol (25, 100 mM) potentiated P2X7R-mediated IL-1beta secretion from BV2 microglia.	Ethanol	13-20	interleukin 1 beta	Mus musculus	61-69
29393276-5	2018	Indomethacin induced small intestinal damage and increased protein levels of cleaved caspase-1 and mature IL-1beta in the small intestine.	Indomethacin	0-12	interleukin 1 beta	Mus musculus	106-114
29393276-7	2018	Isoliquiritigenin also inhibited the indomethacin-induced increase in cleaved caspase-1 and mature IL-1beta protein levels, whereas it did not affect the mRNA expression of NLRP3, ASC, caspase-1, and IL-1beta.	isoliquiritigenin	0-17	interleukin 1 beta	Mus musculus	99-107
29393276-7	2018	Isoliquiritigenin also inhibited the indomethacin-induced increase in cleaved caspase-1 and mature IL-1beta protein levels, whereas it did not affect the mRNA expression of NLRP3, ASC, caspase-1, and IL-1beta.	isoliquiritigenin	0-17	interleukin 1 beta	Mus musculus	200-208
29425654-6	2018	METHODS: In IL-1beta-stimulated FLS cells derived from rheumatoid arthritis patients, the anti-inflammatory activity of ACI was examined by analyzing the expression levels of inflammatory mediators such as TNF-alpha, IL-6, IL-8, MMP-1, MMP-3, MMP-13, PGE2, and COX-2 using ELISA and RT-PCR analysis.	Dinoprostone	251-255	interleukin 1 beta	Mus musculus	12-20
29425654-9	2018	RESULTS: The ethanolic extract (50% v/v) of ACI reduced the levels of TNF-alpha, IL-6, IL-8, MMP-1, and MMP-13 secreted by IL-1beta-stimulated FLS cells, whereas MMP-3, COX-2, and PGE2 were not significantly affected.	Dinoprostone	180-184	interleukin 1 beta	Mus musculus	123-131
29393276-7	2018	Isoliquiritigenin also inhibited the indomethacin-induced increase in cleaved caspase-1 and mature IL-1beta protein levels, whereas it did not affect the mRNA expression of NLRP3, ASC, caspase-1, and IL-1beta.	Indomethacin	37-49	interleukin 1 beta	Mus musculus	99-107
29283990-9	2017	Serum levels of tumor necrosis factor (TNF)-alpha, interferon (IF)-gamma, interleukin (IL)-2, and IL-1beta were reduced by berberine pre-treatment; levels of serum IL-10, an anti-inflammatory cytokine, was elevated.	Berberine	123-132	interleukin 1 beta	Mus musculus	98-106
29393276-7	2018	Isoliquiritigenin also inhibited the indomethacin-induced increase in cleaved caspase-1 and mature IL-1beta protein levels, whereas it did not affect the mRNA expression of NLRP3, ASC, caspase-1, and IL-1beta.	Indomethacin	37-49	interleukin 1 beta	Mus musculus	200-208
29393276-8	2018	Protection against intestinal damage in isoliquiritigenin-treated mice was completely abolished with exogenous IL-1beta.	isoliquiritigenin	40-57	interleukin 1 beta	Mus musculus	111-119
29889084-7	2018	Phenelzine-treated mice showed decreased levels of pro-inflammatory cytokines, such as interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in the injured spinal cord during the acute phase of inflammation.	Phenelzine	0-10	interleukin 1 beta	Mus musculus	87-104
29372003-7	2018	SL-LPS pretreatment strongly enhanced the LPS-induced production of TNF-alpha, IL-6, IL-10, PGE2, and NO in RAW 264.7 cells, and the IL-6, IL-1beta, and CRP levels in Hepa1c1c-7 cells, as well as the ratios of IFN-gamma/IL-10 in LPS- and Con A-stimulated EL4 cells compared to L-LPS.	sl-lps	0-6	interleukin 1 beta	Mus musculus	139-147
29295585-9	2017	The results showed that pre-treatment with acetone-dissolved glycolipids reduced skin edema, epidermal thickness, and pro-inflammatory cytokine production (TNF-alpha, IL-1beta, IL-6, IL-17) in epidermal tissue.	Acetone	43-50	interleukin 1 beta	Mus musculus	167-175
29295585-9	2017	The results showed that pre-treatment with acetone-dissolved glycolipids reduced skin edema, epidermal thickness, and pro-inflammatory cytokine production (TNF-alpha, IL-1beta, IL-6, IL-17) in epidermal tissue.	Glycolipids	61-72	interleukin 1 beta	Mus musculus	167-175
29311940-7	2017	qRT-PCR and ELISA experiments suggested that nuciferine inhibited TNF-alpha, IL-6, and IL-1beta secretion in tissues and RAW264.7 cells but increased IL-10 secretion (p &lt; 0.05).	nuciferine	45-55	interleukin 1 beta	Mus musculus	87-95
29311931-7	2017	In addition, DMY prevented bone loss and decreased serum levels of tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6, and with a decrease in the ratio between receptor activator of nuclear factor-kappaB (RANK) ligand (RANKL) and osteoprotegerin (OPG) in vivo.	dihydromyricetin	13-16	interleukin 1 beta	Mus musculus	96-113
29061706-2	2018	We recently reported that an M. pneumoniae-derived ADP-ribosylating and vacuolating toxin called community-acquired respiratory distress syndrome (CARDS) toxin is capable of triggering NLRP3 (NLR-family, leucine-rich repeat protein 3) inflammasome activation and interleukin-1beta (IL-1beta) secretion in macrophages.	Adenosine Diphosphate	51-54	interleukin 1 beta	Mus musculus	282-290
29146293-5	2017	Andrographolide suppressed overexpression of microglial MIP-1alpha, P2X7 receptor and its downstream signaling mediators including-inflammasome NLRP3, caspase1 and mature IL-1beta.	andrographolide	0-15	interleukin 1 beta	Mus musculus	171-179
29258194-8	2017	In a murine model of subcutaneous MRSA infection, local administration of UA was synergistic with nafcillin to reduce lesion size and inflammatory cytokine (IL-1beta) production.	Nafcillin	98-107	interleukin 1 beta	Mus musculus	157-165
28986252-8	2017	Uric acid inhibited the hippocampal expression of IL-1beta and decreased serum and hippocampus levels of interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha).	Uric Acid	0-9	interleukin 1 beta	Mus musculus	105-122
29217823-6	2017	Furthermore, LPA administration decreased the production of TNF-alpha and IL-1beta in an experimental drug-induced liver injury animal model.	lysophosphatidic acid	13-16	interleukin 1 beta	Mus musculus	74-82
29216926-4	2017	METHODS: We studied bone marrow-derived macrophages from mice with a mutation in the nucleotide-binding oligomerisation domain-containing 2 gene (Nod2 m/m), which exhibit heightened secretion of IL-1beta in response to the peptidoglycan fragment muramyl dipeptide (MDP).	muramyl	246-253	interleukin 1 beta	Mus musculus	195-203
29216926-4	2017	METHODS: We studied bone marrow-derived macrophages from mice with a mutation in the nucleotide-binding oligomerisation domain-containing 2 gene (Nod2 m/m), which exhibit heightened secretion of IL-1beta in response to the peptidoglycan fragment muramyl dipeptide (MDP).	Dipeptides	254-263	interleukin 1 beta	Mus musculus	195-203
29228045-5	2017	The lack of ROS led to reduced production of IL-1beta in macrophages, whereas neutrophil elastase (NE), an abundant product of neutrophils, may potentially exert increased inflammasome-independent protease activity and lead to higher IL-1beta production.	Reactive Oxygen Species	12-15	interleukin 1 beta	Mus musculus	45-53
29197398-7	2017	CRS also increased TLR4 signaling activity, interleukin-1beta, and tumor necrosis factor-alpha expression, microglial activation, and neuronal morphologic changes.	3-cresol	0-3	interleukin 1 beta	Mus musculus	44-61
28918467-9	2017	Moreover, anisodamine treatment reduced expression of ER stress markers IRE-1alpha, CHOP, and ATF4, TXNIP and NLRP3, as well as ACS, Caspase-1, IL-1alpha, IL-1beta, and IL-18, showing moderate protective effect on the changes of above factors comparing with TXNIP or NLRP3 knock down.	anisodamine	10-21	interleukin 1 beta	Mus musculus	155-163
28766178-1	2017	Asbestos and silica (exogenous danger) and adenosine triphosphate (ATP, endogenous danger-signaling molecule) synergistically increase IL-1beta release from endotoxin-primed macrophage, which is mediated by NOD-like receptor protein 3 (NLRP3) inflammasome.	Adenosine Triphosphate	43-65	interleukin 1 beta	Mus musculus	135-143
28176019-11	2017	Erlotinib slightly reduced the urinary protein and suppressed the expression of renal injury markers (Lcn2, Lysozyme) and inflammatory cytokines (Il-6, Il-1beta and KC).	Erlotinib Hydrochloride	0-9	interleukin 1 beta	Mus musculus	152-160
29054824-6	2017	HA treatment significantly decreased the accumulation of inflammatory cells and production of cytokines, including tumor necrosis factor-alpha, interleukin (IL)-6, and IL-1beta, caused by CS and LPS exposure.	Cesium	188-190	interleukin 1 beta	Mus musculus	168-176
28730512-9	2017	We found that KCs and NLRP3 play pro-inflammatory roles in the progression of NASH, probably through secretions of IL-1beta and IL-18 by KCs induced by PA.	Palmitic Acid	152-154	interleukin 1 beta	Mus musculus	115-123
28730512-12	2017	Furthermore, the levels of pro-inflammatory cytokines IL-1beta and IL-18 in the SN of KCs from WT mice were all elevated with the stimulation of PA, and the increase of these cytokines in the SN was blocked by NLRP3 deletion.	Palmitic Acid	145-147	interleukin 1 beta	Mus musculus	54-62
28730512-13	2017	In conclusion, our novel findings demonstrate that NLRP3 plays a pivotal role in NASH development and pro-inflammatory cytokines IL-1beta and IL-18 secretion induced by PA stimulation, and NLRP3 might be an effective potential target for the treatment of liver inflammatory diseases associated with NLRP3 inflammasome activation.	Palmitic Acid	169-171	interleukin 1 beta	Mus musculus	129-137
29203637-6	2017	RESULTS: CoNPs and Co2+ can induce the increase of ROS and inflammatory cytokines, such as tumour necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	Cobalt(2+)	19-23	interleukin 1 beta	Mus musculus	133-150
29203637-6	2017	RESULTS: CoNPs and Co2+ can induce the increase of ROS and inflammatory cytokines, such as tumour necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	Cobalt(2+)	19-23	interleukin 1 beta	Mus musculus	152-160
29185103-12	2017	Aspirin, ticagrelor, and rosuvastatin decreased serum IL-1beta and IL-6 levels.	Aspirin	0-7	interleukin 1 beta	Mus musculus	54-62
29185103-12	2017	Aspirin, ticagrelor, and rosuvastatin decreased serum IL-1beta and IL-6 levels.	Ticagrelor	9-19	interleukin 1 beta	Mus musculus	54-62
29185103-12	2017	Aspirin, ticagrelor, and rosuvastatin decreased serum IL-1beta and IL-6 levels.	Rosuvastatin Calcium	25-37	interleukin 1 beta	Mus musculus	54-62
28744946-8	2017	In addition, these TPM treated mice, also showed a marked reduction in aortic superoxide formation and decreased circulating plasma levels of known pro-inflammatory markers IL-6, MCP-1, IL-1beta, IFN-gamma and TNF-alpha.	Topiramate	19-22	interleukin 1 beta	Mus musculus	186-194
28766178-1	2017	Asbestos and silica (exogenous danger) and adenosine triphosphate (ATP, endogenous danger-signaling molecule) synergistically increase IL-1beta release from endotoxin-primed macrophage, which is mediated by NOD-like receptor protein 3 (NLRP3) inflammasome.	Asbestos	0-8	interleukin 1 beta	Mus musculus	135-143
28766178-1	2017	Asbestos and silica (exogenous danger) and adenosine triphosphate (ATP, endogenous danger-signaling molecule) synergistically increase IL-1beta release from endotoxin-primed macrophage, which is mediated by NOD-like receptor protein 3 (NLRP3) inflammasome.	Silicon Dioxide	13-19	interleukin 1 beta	Mus musculus	135-143
28766178-1	2017	Asbestos and silica (exogenous danger) and adenosine triphosphate (ATP, endogenous danger-signaling molecule) synergistically increase IL-1beta release from endotoxin-primed macrophage, which is mediated by NOD-like receptor protein 3 (NLRP3) inflammasome.	Adenosine Triphosphate	67-70	interleukin 1 beta	Mus musculus	135-143
28766178-4	2017	IL-1beta release was synergistically increased when the cells were exposed to both LPS and ATP or FTiO2, while IL-6 was readily released by LPS alone.	Adenosine Triphosphate	91-94	interleukin 1 beta	Mus musculus	0-8
28766178-4	2017	IL-1beta release was synergistically increased when the cells were exposed to both LPS and ATP or FTiO2, while IL-6 was readily released by LPS alone.	ftio2	98-103	interleukin 1 beta	Mus musculus	0-8
28855315-7	2017	Moreover, eplerenone suppressed IL1b secretion from eWAT of HFD-fed mice.	Eplerenone	10-20	interleukin 1 beta	Mus musculus	32-36
29031142-10	2017	The levels of inflammatory mediators TNF-alpha, IL-1beta, and IL-6 in BALF were also inhibited by SchB.	schizandrin B	98-102	interleukin 1 beta	Mus musculus	48-56
29039445-0	2017	Isoliquiritigenin suppresses IL-1beta induced apoptosis and inflammation in chondrocyte-like ATDC5 cells by inhibiting NF-kappaB and exerts chondroprotective effects on a mouse model of anterior cruciate ligament transection.	isoliquiritigenin	0-17	interleukin 1 beta	Mus musculus	29-37
28643466-11	2017	ANE is a potent protective molecule for OA; it delays OA progression by suppressing ECM loss and chondrocyte hypertrophy partially by suppressing IL-1beta/NF-kappaB pathway activation.	anemonin	0-3	interleukin 1 beta	Mus musculus	146-154
28550659-7	2017	In mice ventilated for 12 h, a significant increase in TNF-alpha, IFN-gamma, IL-1beta, IL-10, and MCP-1 (P &lt; 0.01) was observed with 90% FiO2, whereas IL-6 showed a decreasing trend (P for trend = 0.03) across FiO2 groups.	fio2	140-144	interleukin 1 beta	Mus musculus	77-85
28855315-10	2017	Concerning the second triggering factors, ROS production and ATP- and nigericin-induced IL1b secretion were suppressed by eplerenone in the LPS-primed BMDM.	Adenosine Triphosphate	61-64	interleukin 1 beta	Mus musculus	88-92
28855315-10	2017	Concerning the second triggering factors, ROS production and ATP- and nigericin-induced IL1b secretion were suppressed by eplerenone in the LPS-primed BMDM.	Nigericin	70-79	interleukin 1 beta	Mus musculus	88-92
28855315-10	2017	Concerning the second triggering factors, ROS production and ATP- and nigericin-induced IL1b secretion were suppressed by eplerenone in the LPS-primed BMDM.	Eplerenone	122-132	interleukin 1 beta	Mus musculus	88-92
29135040-8	2017	The serum levels of IFN-gamma, IL-1beta, immunoglobulin A, and Immunoglobulin M were decreased by geniposide and genipin in infected mice.	geniposide	98-108	interleukin 1 beta	Mus musculus	31-39
28940490-6	2017	KEY FINDINGS: Eight amino acids residues in TRPA1 established stable interactions with carvacryl acetate, which led to pharmacological efficacy against CPT-11-induced intestinal mucositis via reduction of both neutropenia and bacteremia, increase in villi height and crypt depth, decrease in pro-inflammatory cytokines (interleukin-1beta, keratinocyte chemoattractant and tumour necrosis factor-alpha) and decrease in malondialdehyde and nitric oxide metabolite levels in the jejunum.	carvacryl acetate	87-104	interleukin 1 beta	Mus musculus	320-337
29135040-8	2017	The serum levels of IFN-gamma, IL-1beta, immunoglobulin A, and Immunoglobulin M were decreased by geniposide and genipin in infected mice.	genipin	113-120	interleukin 1 beta	Mus musculus	31-39
29217355-9	2017	In addition, treatment with high dose of crocetin reduced SNI-induced increase of TNF-alpha and IL-1beta.	crocetin	41-49	interleukin 1 beta	Mus musculus	96-104
29217355-9	2017	In addition, treatment with high dose of crocetin reduced SNI-induced increase of TNF-alpha and IL-1beta.	sni	58-61	interleukin 1 beta	Mus musculus	96-104
28940490-6	2017	KEY FINDINGS: Eight amino acids residues in TRPA1 established stable interactions with carvacryl acetate, which led to pharmacological efficacy against CPT-11-induced intestinal mucositis via reduction of both neutropenia and bacteremia, increase in villi height and crypt depth, decrease in pro-inflammatory cytokines (interleukin-1beta, keratinocyte chemoattractant and tumour necrosis factor-alpha) and decrease in malondialdehyde and nitric oxide metabolite levels in the jejunum.	Irinotecan	152-158	interleukin 1 beta	Mus musculus	320-337
29399025-3	2017	In addition, administration of DML to D-galactose-treated mice significantly ameliorated the microglial activation and increases of IL-1beta, IL-6, and TNF-alpha levels in the hippocampus.	dml	31-34	interleukin 1 beta	Mus musculus	132-140
29180209-6	2017	Meanwhile, costunolide inhibited the expressions of interleukin (IL-1beta) and tumor necrosis factor (TNF-alpha) in liver tissues in a dose-dependent manner.	costunolide	11-22	interleukin 1 beta	Mus musculus	65-73
29399025-3	2017	In addition, administration of DML to D-galactose-treated mice significantly ameliorated the microglial activation and increases of IL-1beta, IL-6, and TNF-alpha levels in the hippocampus.	Galactose	38-49	interleukin 1 beta	Mus musculus	132-140
28942141-7	2017	CORM-3 suppressed caspase-1 activation and the secretion of interleukin (IL)-1beta and IL-18 in macrophages in response to lipopolysaccharide (LPS) and ATP.	Adenosine Triphosphate	152-155	interleukin 1 beta	Mus musculus	60-82
28986232-5	2017	Here, we demonstrate that rifampicin pretreatment alleviated rotenone induced release of IL-1beta and IL-6, and its effects were suppressed when autophagy was inhibited by chloroquine.	Rifampin	26-36	interleukin 1 beta	Mus musculus	89-97
28986232-5	2017	Here, we demonstrate that rifampicin pretreatment alleviated rotenone induced release of IL-1beta and IL-6, and its effects were suppressed when autophagy was inhibited by chloroquine.	Rotenone	61-69	interleukin 1 beta	Mus musculus	89-97
29166724-8	2017	Masson staining results showed that the degree of myocardial fibrosis in MI+ Sch B group was significantly less than that of MI+ vehicle group.Moreover, Sch B could down-regulate some inflammatory cytokines, like NF-kappaB TGF-beta TNF-alpha and IL-1beta, activate Akt-eNOS pathway, upgrade Bcl-2 and downgrade Bax and reduce cell apoptosis as compared with MI+ vehicle group (all P&lt;0.05).	schizandrin B	77-82	interleukin 1 beta	Mus musculus	246-254
28784305-8	2017	After hepatic I/R injury, WT and NLRC5-/- mice pre-treated with DEX exhibited attenuated histological disruption, and reduced pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, IL-1beta and inducible nitric oxide synthase (iNOS), which was associated with the inactivated NF-kappaB pathway.	Dexmedetomidine	64-67	interleukin 1 beta	Mus musculus	225-233
27957680-7	2017	Expression of NLRP3 inflammasome proteins and levels of activated caspase 1 and mature interleukin 1 beta were significantly reduced in SOD1(G93A) mice supplemented with E2.	Estradiol	170-172	interleukin 1 beta	Mus musculus	87-105
28990048-0	2017	Chlorogenic acid suppresses lipopolysaccharide-induced nitric oxide and interleukin-1beta expression by inhibiting JAK2/STAT3 activation in RAW264.7 cells.	Chlorogenic Acid	0-16	interleukin 1 beta	Mus musculus	72-89
29039503-0	2017	Inhibitory effects of lupane-type triterpenoid saponins from the leaves of Acanthopanax gracilistylus on lipopolysaccharide-induced TNF-alpha, IL-1beta and high-mobility group box 1 release in macrophages.	lupane	22-28	interleukin 1 beta	Mus musculus	143-151
29039503-0	2017	Inhibitory effects of lupane-type triterpenoid saponins from the leaves of Acanthopanax gracilistylus on lipopolysaccharide-induced TNF-alpha, IL-1beta and high-mobility group box 1 release in macrophages.	Saponins	47-55	interleukin 1 beta	Mus musculus	143-151
29039503-8	2017	The results demonstrated that these five saponins significantly suppressed LPS-induced expression of TNF-alpha and IL-1beta at the mRNA and protein level in RAW264.7 cells.	Saponins	41-49	interleukin 1 beta	Mus musculus	115-123
29039503-10	2017	Taken together, these results suggested that the anti-inflammatory activity of AGS-derived saponins may be associated with the downregulation of TNF-alpha and IL-1beta, and the "late-phase" proinflammatory cytokine HMGB1, via negative regulation of the NF-kappaB pathway in RAW264.7 cells.	Saponins	91-99	interleukin 1 beta	Mus musculus	159-167
28228044-11	2017	In addition, WFA decreased the expression of pro-inflammatory mediators such as IL-1beta (11.20 +- 1.96 ng/mL vs. 17.59 +- 1.42 ng/mL) and TNF-alpha (57.38 +- 3.57 pg/mL vs. 95.06 +- 9.13 pg/mL).	withaferin A	13-16	interleukin 1 beta	Mus musculus	80-88
29024091-8	2017	CD also inhibited the pro-inflammatory cytokines (TNF-alpha, IL-18, and IL-1beta) production in serum.	Cadmium	0-2	interleukin 1 beta	Mus musculus	72-80
29024091-9	2017	Furthermore, CD suppressed the LPS-induced NLRP3, Caspase-1, and IL-1beta mRNA expression in lung, as well as the expression of NLRP3 and Caspase-1 (p20) protein.	Cadmium	13-15	interleukin 1 beta	Mus musculus	65-73
28942141-9	2017	Furthermore, CORM-3-treated mice showed substantial reduction in IL-1beta production by hyperglycemia in a mouse model of streptozotocin (STZ)-induced diabetes.	Streptozocin	122-136	interleukin 1 beta	Mus musculus	65-73
28942141-9	2017	Furthermore, CORM-3-treated mice showed substantial reduction in IL-1beta production by hyperglycemia in a mouse model of streptozotocin (STZ)-induced diabetes.	Streptozocin	138-141	interleukin 1 beta	Mus musculus	65-73
29184437-0	2017	Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1beta, IL-6, and TNF-alpha in a mouse model of neuropathic pain.	zerumbone	49-58	interleukin 1 beta	Mus musculus	82-90
28605578-8	2017	We found that both LPS plus ATP and Abeta25-35 enhanced the conversion of pro-caspase-1 to cleaved-caspase-1 and increased the production of mature IL-1beta in BV-2 cells.	Adenosine Triphosphate	28-31	interleukin 1 beta	Mus musculus	148-156
28933476-6	2017	Mechanistically, we found that piceatannol inhibited IL-1beta-induced nuclear factor kappa B (NF-kappaB) activation by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway.	3,3',4,5'-tetrahydroxystilbene	31-42	interleukin 1 beta	Mus musculus	53-61
29135917-4	2017	Supplementation with asperlin also suppressed LPS-elicited production of pro-inflammatory factors in RAW264.7 macrophages, decreased the expression levels of iNOS, IL-1beta and TNFalpha, and increased the expression of IL-10 and IL-4, indicating a remarkable shift in M1/M2 macrophages polarization.	asperlin	21-29	interleukin 1 beta	Mus musculus	164-172
29160418-12	2017	Vitamin D levels correlated negatively with body weight, lung resistance levels at 25 mg/mL of methacholine, total inflammatory cells, and IL-1beta and IL-17 concentrations in BALF.	Vitamin D	0-9	interleukin 1 beta	Mus musculus	139-147
29096659-9	2017	Lidocaine suppressed morphine-induced activation of microglia and downregulated inflammatory cytokines, interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) via upregulating SOCS3 by activating AMPK.	Lidocaine	0-9	interleukin 1 beta	Mus musculus	104-121
28890346-12	2017	MFA treatment remarkably inhibited the expression of inflammatory factors tumour necrosis factor (TNF)-alpha, monocyte chemoattractant protein 1 (MCP-1), interleukin (IL)-1beta and IL-6.	mfa	0-3	interleukin 1 beta	Mus musculus	154-176
28972154-4	2017	We found that when incubated in buffer with up to 20 mm glucose, human and murine neutrophils, but not monocytes, generate progressively more MPs with high interleukin (IL)-1beta content.	Glucose	56-63	interleukin 1 beta	Mus musculus	156-178
28821450-7	2017	Administration of carvedilol significantly inhibited expression of IL-1beta, TNF-alpha, and IL-6 at both the mRNA and protein levels.	Carvedilol	18-28	interleukin 1 beta	Mus musculus	67-75
29096659-9	2017	Lidocaine suppressed morphine-induced activation of microglia and downregulated inflammatory cytokines, interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) via upregulating SOCS3 by activating AMPK.	Lidocaine	0-9	interleukin 1 beta	Mus musculus	123-131
29096659-9	2017	Lidocaine suppressed morphine-induced activation of microglia and downregulated inflammatory cytokines, interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) via upregulating SOCS3 by activating AMPK.	Morphine	21-29	interleukin 1 beta	Mus musculus	104-121
29096659-9	2017	Lidocaine suppressed morphine-induced activation of microglia and downregulated inflammatory cytokines, interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) via upregulating SOCS3 by activating AMPK.	Morphine	21-29	interleukin 1 beta	Mus musculus	123-131
28941191-6	2017	PNU282987 also significantly inhibited the activation of NLRP3 inflammasome and thus decreased the production of IL-1beta and IL-18 both in lipopolysaccharide (LPS)/ATP-stimulated BV2 microglia in vitro and spinal cord from EAE mice in vivo, while inverse effects were observed in alpha7nAChR knockout mice.	PNU-282987	0-9	interleukin 1 beta	Mus musculus	113-121
27699959-6	2017	In wild-type female adolescent mice, intermittent ethanol treatment increased the levels of several cytokines (IL-17A and IL-1beta) and chemokines (MCP-1, MIP-1alpha and fractalkine) in PFC and in serum (IL-17A, MCP-1 and MIP-1alpha), but significant differences in the fractalkine levels in PFC were observed only in male mice.	Ethanol	50-57	interleukin 1 beta	Mus musculus	122-130
28711598-6	2017	Further investigation showed that high glucose induced KLF5 nitration by iNOS-mediated peroxynitrite generation, and nitrated KLF5 increased its interaction with NF-kappaB p50 and thus cooperatively activated the expression of inflammatory cytokines TNF-alpha and IL-1beta.	Glucose	39-46	interleukin 1 beta	Mus musculus	264-272
28711598-9	2017	Together, the present findings were the first to show that KLF5 expression and nitration by iNOS-mediated peroxynitrite are necessary for the induction of TNF-alpha and IL-1beta expression in VSMCs of diabetic vascular tissues.	Peroxynitrous Acid	106-119	interleukin 1 beta	Mus musculus	169-177
28800679-6	2017	KEY RESULTS: The results show that SB decreased LPS-induced disruption in mammary tissues, infiltration of inflammatory cells and the levels of TNF-alpha, IL-6 and IL-1beta.	Butyric Acid	35-37	interleukin 1 beta	Mus musculus	164-172
28941191-6	2017	PNU282987 also significantly inhibited the activation of NLRP3 inflammasome and thus decreased the production of IL-1beta and IL-18 both in lipopolysaccharide (LPS)/ATP-stimulated BV2 microglia in vitro and spinal cord from EAE mice in vivo, while inverse effects were observed in alpha7nAChR knockout mice.	Adenosine Triphosphate	165-168	interleukin 1 beta	Mus musculus	113-121
28780379-9	2017	In contrast, Mif-/-STZ lacked serum MIF levels and showed smaller increases in blood glucose, less TNF-alpha, IL-1beta, CPR, ALT and AST, and failure to develop clinical signs of disease compared to the WT/STZ group.	Streptozocin	19-22	interleukin 1 beta	Mus musculus	110-118
28974441-6	2017	Pro-inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6, were reduced by tyrosol in bronchoalveolar lavage fluid and lung tissue.	4-hydroxyphenylethanol	115-122	interleukin 1 beta	Mus musculus	65-87
28765172-1	2017	In visceral leishmaniasis, we found that the antileishmanial drug Amp B produces a higher level of IL-1beta over the infected control.	Amphotericin B	66-71	interleukin 1 beta	Mus musculus	99-107
28765172-2	2017	Moreover, administering anti-IL-1beta antibody to infected Amp B-treated mice showed significantly less parasite clearance.	Amphotericin B	59-64	interleukin 1 beta	Mus musculus	29-37
28982049-6	2017	In particular, THI-61 induced translocation of Nrf2 from cytosol into the nucleus by an increased Nrf2-ARE binding activity, and reduced IL-1beta production in LPS-activated RAW264.7 cells.	2-acetyl-4(5)-tetrahydroxybutylimidazole	15-18	interleukin 1 beta	Mus musculus	137-145
28938188-5	2017	The results showed that the mammary gland damage, production of inflammatory cytokines IL-1beta, and MPO activity in mammary gland tissues were significantly reduced after pretreated with hemin compared with the group of LPS stimulation only.	Hemin	188-193	interleukin 1 beta	Mus musculus	87-95
28926773-6	2017	SP600125 treatment before infection significantly inhibited IL-1beta production compared with DMSO control both in mice corneas and THP-1 macrophages.	pyrazolanthrone	0-8	interleukin 1 beta	Mus musculus	60-68
28778811-5	2017	Furthermore, adolescent ES treatment inhibited these depression- and anxiety-like behaviours, decreased the levels of IL-1beta, and increased the level of IL-10 in the HPV.	Citalopram	24-26	interleukin 1 beta	Mus musculus	118-126
29163487-9	2017	Baicalin administration also significantly reduced IL-1beta levels in the sera of bacterial infected mice.	baicalin	0-8	interleukin 1 beta	Mus musculus	51-59
29117277-6	2017	Further, naringenin inhibited alkali-induced cytokine (IL-1beta and IL-6) production, Vegf, Pdgf, and Mmp14 mRNA expression, and the reduction of ferric reducing antioxidant power and Azinobis-(3-Ethylbenzothiazoline 6-Sulfonic acid) radical scavenging capacity as well as increased the reduced glutathione and protein-bound sulfhydryl groups levels.	naringenin	9-19	interleukin 1 beta	Mus musculus	55-63
28972095-4	2017	IL-1beta was released from the I/R liver and its deficiency reduced reactive oxygen species generation, apoptosis, and inflammatory responses, such as inflammatory cell infiltration and cytokine expression, thereby resulting in reduced tissue injury.	Reactive Oxygen Species	68-91	interleukin 1 beta	Mus musculus	0-8
29104209-13	2017	Moreover, pseudane-VII treatment dose-dependently reduced mRNA levels of pro-inflammatory cytokines including inos, cox-2, il-1beta, tnf-alpha, and il-6 in LPS-stimulated macrophages.	pseudane	10-18	interleukin 1 beta	Mus musculus	123-131
29104230-3	2017	glycoside administration leads to increased spleen macrophage activating markers iba-1, IL-1beta, iNOs, ROS and NO formation, with additional change of macrophage phenotype to M1.	Glycosides	0-9	interleukin 1 beta	Mus musculus	88-96
29098024-9	2017	AZM also down-regulated the concentration and mRNA expression of interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha and transforming growth factor-beta1.	Azithromycin	0-3	interleukin 1 beta	Mus musculus	65-87
29016795-10	2017	Furthermore, leonurine (60 mg/kg) significantly inhibited the production of proinflammatory cytokine interleukin-1beta, interleukin-6 and TNF-alpha, and suppressed the nuclear factor kappa B signaling pathway.	leonurine	13-22	interleukin 1 beta	Mus musculus	101-118
29016824-7	2017	Treatment with the antidepressant amitriptyline failed to block NLRP3-dependent activation of caspase-1, but inhibited lipopolysaccharide-promoted production of interleukin-1beta mRNA via suppressing NF-kappaB signaling in mouse mixed glial cultures.	Amitriptyline	34-47	interleukin 1 beta	Mus musculus	161-178
28624900-3	2017	Here we show that in C57BL/6 mice, the most commonly applied strain for genetic modification, doxycycline treatment lowered transcription of the genes Il1b, Il10, Il18, Tnf, Cxcl1, and Cxcl2 in the ileum, and of the gene Il18 in colon.	Doxycycline	94-105	interleukin 1 beta	Mus musculus	151-155
28905319-7	2017	Our data suggested that levels of interleukin 1beta (IL-1beta) and IL-18 in the KCs and mice treated with wortmannin were significantly lower than that of IGF-1.	Wortmannin	106-116	interleukin 1 beta	Mus musculus	34-51
28905319-7	2017	Our data suggested that levels of interleukin 1beta (IL-1beta) and IL-18 in the KCs and mice treated with wortmannin were significantly lower than that of IGF-1.	Wortmannin	106-116	interleukin 1 beta	Mus musculus	53-61
29239334-7	2017	Calycosin diminished hippocampal beta amyloid, Tau protein, interleukin-1beta, tumor necrosis factor-alpha, acetylcholinesterase and malondialdehyde levels in a dose-dependent manner, and increased acetylcholine and glutathione activities.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	interleukin 1 beta	Mus musculus	60-106
27256583-0	2017	Resveratrol suppressed seizures by attenuating IL-1beta, IL1-Ra, IL-6, and TNF-alpha in the hippocampus and cortex of kindled mice.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	47-55
28472013-6	2017	Reoxygenation with 100% oxygen significantly increased TNF-alpha (2.5 h after hypoxia), IL-1beta (5 h after hypoxia), caspase-3 (8 h after hypoxia) mRNA levels in the whole brain compared with 21% oxygen, and significantly decreased erythropoietin mRNA expression compared with 21% oxygen 9 h after reoxygenation.	Oxygen	2-8	interleukin 1 beta	Mus musculus	88-96
28472013-6	2017	Reoxygenation with 100% oxygen significantly increased TNF-alpha (2.5 h after hypoxia), IL-1beta (5 h after hypoxia), caspase-3 (8 h after hypoxia) mRNA levels in the whole brain compared with 21% oxygen, and significantly decreased erythropoietin mRNA expression compared with 21% oxygen 9 h after reoxygenation.	Oxygen	24-30	interleukin 1 beta	Mus musculus	88-96
28472013-6	2017	Reoxygenation with 100% oxygen significantly increased TNF-alpha (2.5 h after hypoxia), IL-1beta (5 h after hypoxia), caspase-3 (8 h after hypoxia) mRNA levels in the whole brain compared with 21% oxygen, and significantly decreased erythropoietin mRNA expression compared with 21% oxygen 9 h after reoxygenation.	Oxygen	24-30	interleukin 1 beta	Mus musculus	88-96
29084176-4	2017	Our results showed that SiO2 plain NPs induced NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome activation, increasing interleukin (IL)-1beta release in vitro, and, to a lesser extent, in vivo.	Silicon Dioxide	24-28	interleukin 1 beta	Mus musculus	139-161
28858765-5	2017	These seven selected triazoles inhibited P2X7R mediated interleukin-1 (IL-1beta) release.	Triazoles	21-30	interleukin 1 beta	Mus musculus	71-79
29123466-11	2017	BCP also decreased high-mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels.	caryophyllene	0-3	interleukin 1 beta	Mus musculus	83-100
29123466-11	2017	BCP also decreased high-mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels.	caryophyllene	0-3	interleukin 1 beta	Mus musculus	102-110
29069584-5	2017	DCs activated by excess sodium produce increased interleukin-1beta (IL-1beta) and promote T cell production of cytokines IL-17A and interferon gamma (IFN-gamma).	Sodium	24-30	interleukin 1 beta	Mus musculus	49-66
29069584-5	2017	DCs activated by excess sodium produce increased interleukin-1beta (IL-1beta) and promote T cell production of cytokines IL-17A and interferon gamma (IFN-gamma).	Sodium	24-30	interleukin 1 beta	Mus musculus	68-76
29073178-6	2017	Tumour necrosis factor-alpha (TNFalpha) and interleukin-1 beta (IL-1beta) levels, in addition to total protein concentration were all significantly reduced in BALF from mice treated with the extract or 6-bromoisatin.	6-bromoisatin	202-215	interleukin 1 beta	Mus musculus	44-62
29073178-6	2017	Tumour necrosis factor-alpha (TNFalpha) and interleukin-1 beta (IL-1beta) levels, in addition to total protein concentration were all significantly reduced in BALF from mice treated with the extract or 6-bromoisatin.	6-bromoisatin	202-215	interleukin 1 beta	Mus musculus	64-72
28924012-0	2017	Inhibition of IL-1beta Signaling Normalizes NMDA-Dependent Neurotransmission and Reduces Seizure Susceptibility in a Mouse Model of Creutzfeldt-Jakob Disease.	N-Methylaspartate	44-48	interleukin 1 beta	Mus musculus	14-22
29061958-11	2017	ALA (100 and 300 mg/kg) intervention to estrogen-deficiency induced bone loss mice (ovariectomized) showed reductions in TRAP+ osteoclasts count, CTX-I expression, levels of IL-1beta, IL-2, IL-6, IL10, TNF-alpha and MCP-1 and iNOS and COX-2.	alpha-Linolenic Acid	0-3	interleukin 1 beta	Mus musculus	174-182
28677156-5	2017	Conversely, dioscin improved the secretion of pro-inflammatory cytokines (IL-6, TNFalpha, and IL-1beta), and the phagocytic capacity of tumor-associated macrophages by increasing M2-to-M1 phenotype transition.	dioscin	12-19	interleukin 1 beta	Mus musculus	94-102
29053632-10	2017	Furthermore, ZJF attenuated APAP-induced inflammatory mediator production, such as nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta).	zjf	13-16	interleukin 1 beta	Mus musculus	168-185
29053632-10	2017	Furthermore, ZJF attenuated APAP-induced inflammatory mediator production, such as nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta).	zjf	13-16	interleukin 1 beta	Mus musculus	187-195
29053632-10	2017	Furthermore, ZJF attenuated APAP-induced inflammatory mediator production, such as nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta).	Acetaminophen	28-32	interleukin 1 beta	Mus musculus	187-195
28653829-2	2017	Our studies established that JC-171 dose dependently inhibited LPS/ATP-induced interleukin-1beta (IL-1beta) release from J774A.1 macrophages with an IC50 of 8.45 +- 1.56 muM.	CHEMBL4583133	29-35	interleukin 1 beta	Mus musculus	79-96
28653829-2	2017	Our studies established that JC-171 dose dependently inhibited LPS/ATP-induced interleukin-1beta (IL-1beta) release from J774A.1 macrophages with an IC50 of 8.45 +- 1.56 muM.	CHEMBL4583133	29-35	interleukin 1 beta	Mus musculus	98-106
28653829-2	2017	Our studies established that JC-171 dose dependently inhibited LPS/ATP-induced interleukin-1beta (IL-1beta) release from J774A.1 macrophages with an IC50 of 8.45 +- 1.56 muM.	Adenosine Triphosphate	67-70	interleukin 1 beta	Mus musculus	79-96
28653829-2	2017	Our studies established that JC-171 dose dependently inhibited LPS/ATP-induced interleukin-1beta (IL-1beta) release from J774A.1 macrophages with an IC50 of 8.45 +- 1.56 muM.	Adenosine Triphosphate	67-70	interleukin 1 beta	Mus musculus	98-106
29040966-5	2017	Celastrol down-regulated the mRNA levels of macrophage M1 biomarkers (e.g., IL-6, IL-1beta, TNF-alpha, iNOS) in cell culture and in mice.	celastrol	0-9	interleukin 1 beta	Mus musculus	82-90
28798231-6	2017	Also, using the reactive oxygen species (ROS) scavengers N-acetyl cysteine and Mito-TEMPO, we determined that mitochondrial reactive oxygen species are required for P2X7R-mediated IL-1beta release.	Reactive Oxygen Species	16-39	interleukin 1 beta	Mus musculus	180-188
29066896-3	2017	Aminated gamma-PGA nanomicelles (aPNMs) induced NLRP3 inflammasome activation and the subsequent release of proinflammatory IL-1beta.	poly(gamma-glutamic acid)	9-18	interleukin 1 beta	Mus musculus	124-132
28822761-10	2017	In addition, CIH elevated vascular expression of NADPH oxidase 4 and dihydroethidium fluorescence, and increased expression of proinflammatory cytokines TNF-alpha and IL-1beta in both LFD and HFD groups, but these increases was significantly greater in HFD group, along with decreased vascular eNOS activity.	cih	13-16	interleukin 1 beta	Mus musculus	167-175
28798231-6	2017	Also, using the reactive oxygen species (ROS) scavengers N-acetyl cysteine and Mito-TEMPO, we determined that mitochondrial reactive oxygen species are required for P2X7R-mediated IL-1beta release.	Reactive Oxygen Species	41-44	interleukin 1 beta	Mus musculus	180-188
28798231-6	2017	Also, using the reactive oxygen species (ROS) scavengers N-acetyl cysteine and Mito-TEMPO, we determined that mitochondrial reactive oxygen species are required for P2X7R-mediated IL-1beta release.	Acetylcysteine	57-74	interleukin 1 beta	Mus musculus	180-188
28798231-6	2017	Also, using the reactive oxygen species (ROS) scavengers N-acetyl cysteine and Mito-TEMPO, we determined that mitochondrial reactive oxygen species are required for P2X7R-mediated IL-1beta release.	Reactive Oxygen Species	124-147	interleukin 1 beta	Mus musculus	180-188
28933629-10	2017	In macrophages, ezetimibe blocked the NLRP3 inflammasome-IL1B pathway in an autophagy-dependent manner and modulated hepatocyte-macrophage interaction via extracellular vesicles.	Ezetimibe	16-25	interleukin 1 beta	Mus musculus	57-61
29160373-5	2017	RESULTS: TSA significantly increased the expression of p-Akt, p-GSK-3beta proteins and the levels of SOD, Bcl-2, reduced the infarct volume and the levels of MDA, ROS, TNF-alpha, IL-1beta, Bax, Caspase-3, TUNEL and attenuated neurological deficit in mice with transient MCAO, LY294002 weakened such effect of TSA dramatically.	trichostatin A	9-12	interleukin 1 beta	Mus musculus	179-187
28912118-8	2017	In a single-dose UV (200 mJ/cm2)-induced skin inflammation mouse model, carvedilol (10 mumol/L), applied topically after UV exposure, reduced skin hyperplasia and the levels of cyclobutane pyrimidine dimers, IL1beta, IL6, and COX-2 in skin.	Carvedilol	72-82	interleukin 1 beta	Mus musculus	208-215
29107326-12	2017	Alkyl glycerol ethers administration increased IL-10 and decreased IL-1beta hippocampal expression in animals with neuropathic pain.	alkyl glycerol ethers	0-21	interleukin 1 beta	Mus musculus	67-75
28750357-5	2017	Further study revealed that WEL treatment dramatically inhibited NLRP3 inflammasome activation and caspase-1 phosphorylation to decrease IL-1beta release in colons treated with DSS.	dss	177-180	interleukin 1 beta	Mus musculus	137-145
28923306-7	2017	Baicalein treatment also inhibited the cuprizone-induced increase in Iba1-positive microglia (P&lt;0.001), GFAP-positive astrocytes (P&lt;0.001), and the gene expressions of CD11b (P&lt;0.01), GFAP (P&lt;0.05), TNFalpha (P&lt;0.05), IL-1beta (P&lt;0.05), and iNOS (p&lt;0.01).	baicalein	0-9	interleukin 1 beta	Mus musculus	233-241
28923306-7	2017	Baicalein treatment also inhibited the cuprizone-induced increase in Iba1-positive microglia (P&lt;0.001), GFAP-positive astrocytes (P&lt;0.001), and the gene expressions of CD11b (P&lt;0.01), GFAP (P&lt;0.05), TNFalpha (P&lt;0.05), IL-1beta (P&lt;0.05), and iNOS (p&lt;0.01).	Cuprizone	39-48	interleukin 1 beta	Mus musculus	233-241
28810537-7	2017	The IL-6, IL-1beta and TNF-a levels were all decreased by cilostazol.	Cilostazol	58-68	interleukin 1 beta	Mus musculus	10-18
28472825-5	2017	We found that Lycopene notably prevented the increase of IL-1beta, TNFalpha and CRP levels in mice fed HFD.	Lycopene	14-22	interleukin 1 beta	Mus musculus	57-65
28669743-8	2017	On the other hand, BzATP-mediated increased number of activated microglia and increased survival kinase levels in addition to increased caspase-1 and IL-1beta levels indicate the complex nature of the P2X7 receptor-mediated signaling in neuronal injury.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	19-24	interleukin 1 beta	Mus musculus	150-158
28669743-7	2017	These results indicated that inhibition of P2X7R with BBG promoted neuronal survival, not through the activation of survival kinase pathways, but possibly by improved intracellular Ca2+ overload and decreased the levels of Caspase 1, IL-1beta and Bax proteins.	coomassie Brilliant Blue	54-57	interleukin 1 beta	Mus musculus	234-242
28924088-5	2017	In RAW264.7 cells stimulated by lipopolysaccharide (LPS), n-3 DPA significantly down-regulated mRNA expression of pro-inflammatory factors such as IL-6, IL-1beta, iNOS and COX-2.	n-3 dpa	58-65	interleukin 1 beta	Mus musculus	153-161
28695367-0	2017	Paeonol Inhibits IL-1beta-Induced Inflammation via PI3K/Akt/NF-kappaB Pathways: In Vivo and Vitro Studies.	paeonol	0-7	interleukin 1 beta	Mus musculus	17-25
28695367-10	2017	The results showed that pretreatment with paeonol could inhibit IL-1beta-induced NO and PGE2 production.	paeonol	42-49	interleukin 1 beta	Mus musculus	64-72
28695367-10	2017	The results showed that pretreatment with paeonol could inhibit IL-1beta-induced NO and PGE2 production.	Dinoprostone	88-92	interleukin 1 beta	Mus musculus	64-72
28695367-12	2017	Moreover, paeonol was found to inhibit IL-1beta-induced NF-kappaB activation, PI3K, and AKT phosphorylation.	paeonol	10-17	interleukin 1 beta	Mus musculus	39-47
29103460-8	2017	Ginsenoside Rk1 inhibited lipopolysaccharide-induced expression of nitric oxide (NO), interleukin (IL)-6, IL-1beta, tumor necrosis factor (TNF)-alpha, and monocyte chemotactic protein (MCP)-1.	Ginsenosides	0-11	interleukin 1 beta	Mus musculus	106-114
28639050-12	2017	Paeoniflorin suppressed STZ-induced IBA-1 and IL-1beta expression and decreased STZ-induced high blood glucose level.	peoniflorin	0-12	interleukin 1 beta	Mus musculus	46-54
28639050-12	2017	Paeoniflorin suppressed STZ-induced IBA-1 and IL-1beta expression and decreased STZ-induced high blood glucose level.	Streptozocin	24-27	interleukin 1 beta	Mus musculus	46-54
28646427-8	2017	TSA-treated mice showed a significant reduction of C-reactive protein (CRP), ox-LDL, IL-1beta, IL-6, IL-12, and TNF-alpha in ELISA data.	tanshinone	0-3	interleukin 1 beta	Mus musculus	85-93
28646427-9	2017	Real-time PCR analyses showed that TSA decreased the expression of CCL-2, CD40, IL-1beta, IL-6, TNF-alpha, and MMP-2 in heart and aorta tissues.	tanshinone	35-38	interleukin 1 beta	Mus musculus	80-88
28663379-7	2017	Pulmonary corticosterone levels were negatively correlated with IL-1beta, IL-18, and MCP-1.	Corticosterone	10-24	interleukin 1 beta	Mus musculus	64-72
28598954-10	2017	Excitingly, we demonstrate that SGLT2 inhibition with dapagliflozin promoted a trend towards reduced tumour necrosis factor-alpha and elevated IL-1beta protein levels in the kidney.	dapagliflozin	54-67	interleukin 1 beta	Mus musculus	143-151
28924088-8	2017	Furthermore, expression levels of IL-6 and IL-1beta mRNAs were measured in the presence of the delta-6 desaturase inhibitor SC26196 in the culture medium to inhibit the conversion of n-3 DPA to DHA.	SC 26196	124-131	interleukin 1 beta	Mus musculus	43-51
28924088-8	2017	Furthermore, expression levels of IL-6 and IL-1beta mRNAs were measured in the presence of the delta-6 desaturase inhibitor SC26196 in the culture medium to inhibit the conversion of n-3 DPA to DHA.	n-3 dpa	183-190	interleukin 1 beta	Mus musculus	43-51
28924088-8	2017	Furthermore, expression levels of IL-6 and IL-1beta mRNAs were measured in the presence of the delta-6 desaturase inhibitor SC26196 in the culture medium to inhibit the conversion of n-3 DPA to DHA.	Docosahexaenoic Acids	194-197	interleukin 1 beta	Mus musculus	43-51
28765895-0	2017	Oligomeric proanthocyanidins inhibit apoptosis of chondrocytes induced by interleukin-1beta.	Proanthocyanidins	11-28	interleukin 1 beta	Mus musculus	74-91
28662409-6	2017	The results showed an alleviated pulmonary inflammation and fibrosis in myeloid differentiation primary response gene 88 (MyD88)-deficient mice treated with bleomycin (BLM), accompanied with a reduced TGF-beta signaling and production of pro-fibrotic cytokines, including TNF-alpha, IL-1beta.	Bleomycin	157-166	interleukin 1 beta	Mus musculus	283-291
28802904-11	2017	Moreover, increased levels of inflammatory cytokines, such as TNF-alpha, IL-1beta, and IL-6, have been identified in damaged colon tissue, which was noticeably reduced by baicalin treatment.	baicalin	171-179	interleukin 1 beta	Mus musculus	73-81
27730511-4	2017	P2X7 receptor activation by extracellular ATP leads to maturation and release of IL-1beta by immune cells, which stimulates the production of oxygen reactive species.	Adenosine Triphosphate	42-45	interleukin 1 beta	Mus musculus	81-89
27730511-4	2017	P2X7 receptor activation by extracellular ATP leads to maturation and release of IL-1beta by immune cells, which stimulates the production of oxygen reactive species.	Oxygen	142-148	interleukin 1 beta	Mus musculus	81-89
27730511-4	2017	P2X7 receptor activation by extracellular ATP leads to maturation and release of IL-1beta by immune cells, which stimulates the production of oxygen reactive species.	species	158-165	interleukin 1 beta	Mus musculus	81-89
28765895-14	2017	Taken together, the results of the present study suggest that OPC protects chondrocytes against IL-1beta-induced damage by decreasing ROS content and MMP levels.	Reactive Oxygen Species	134-137	interleukin 1 beta	Mus musculus	96-104
28849050-9	2017	In addition, mRNA and protein expression levels of TNF-alpha, IL-1beta, IL-6 and TGF-beta1 were downregulated following naringenin treatment.	naringenin	120-130	interleukin 1 beta	Mus musculus	62-70
28791390-3	2017	The results of the present study demonstrated that administration of MG caused inhibition of the activation of NACHT, LRR and PYD domains-containing protein 3 and interleukin-1beta production.	magnolol	69-71	interleukin 1 beta	Mus musculus	163-180
28849116-8	2017	The present study demonstrated that scutellarin prevented CIA, and inhibited the expression of inflammation factors, IL-1beta, IL-6 and TNF-alpha.	scutellarin	36-47	interleukin 1 beta	Mus musculus	117-125
28712049-6	2017	Interestingly, Meth treatment significantly increased TLR4 expression, activated the NF-kappaB signaling pathway, and promoted TNF-alpha, IL-6 and IL-1beta excretion.	Methamphetamine	15-19	interleukin 1 beta	Mus musculus	147-155
28608235-12	2017	However ferulic acid supplementation with levetiracetam ameliorated comorbid depression supported with restored circulating corticosterone levels, decreased proinflammatory cytokines (IL-1beta, TNF-alpha) and indoleamine 2,3-dioxygenase activity in mice brain.	ferulic acid	8-20	interleukin 1 beta	Mus musculus	184-192
29169413-8	2017	The levels of TNF-alpha, IL-1beta, IL-6, NO and PGE2 were significantly up-regulated in cell culture media after stimulated with LPS, but the levels of those inflammatory mediators were reduced by DAPT.	dapt	197-201	interleukin 1 beta	Mus musculus	25-33
28608235-12	2017	However ferulic acid supplementation with levetiracetam ameliorated comorbid depression supported with restored circulating corticosterone levels, decreased proinflammatory cytokines (IL-1beta, TNF-alpha) and indoleamine 2,3-dioxygenase activity in mice brain.	Levetiracetam	42-55	interleukin 1 beta	Mus musculus	184-192
28729222-11	2017	Spinal cord immunohistochemistry revealed that preventive treatment with BCP reduced p38 MAPK and NF-kappaB activation, as well as the increased Iba-1 and IL-1beta immunoreactivity promoted by PTX.	caryophyllene	73-76	interleukin 1 beta	Mus musculus	155-163
28729222-11	2017	Spinal cord immunohistochemistry revealed that preventive treatment with BCP reduced p38 MAPK and NF-kappaB activation, as well as the increased Iba-1 and IL-1beta immunoreactivity promoted by PTX.	Paclitaxel	193-196	interleukin 1 beta	Mus musculus	155-163
28624598-8	2017	This in turn led to the blockade of iNOS and COX-2, thereby inhibiting the production of nitric oxide and pro inflammatory cytokines such as TNF-alpha, IL-6, MCP-1 and IL-1beta.	Nitric Oxide	89-101	interleukin 1 beta	Mus musculus	168-176
28941865-10	2017	RESULTS: The experiment showed that curcumin markedly inhibited SCI-induced production of inflammatory mediators, including TNF-alpha, IL-1beta, IL-6 (ELISA assay) and nitrite oxide (Griess method) in a concentration-dependent manner.	Curcumin	36-44	interleukin 1 beta	Mus musculus	135-143
29070142-4	2017	RESULTS: The allo-HSCT aGVHD mouse model was successfully established, the intraperitoneal injection of BBG alleviated the aGVHD clinical manifestations including roachback, ruffled fur, skin peeling and weight loss of recipient mice, decreased P2X7R and IL-1beta expression and reduced the mRNA levels of P2X7R, NLRP3, Caspase-1, IL-1beta and IL-18.	coomassie Brilliant Blue	104-107	interleukin 1 beta	Mus musculus	255-263
29070142-4	2017	RESULTS: The allo-HSCT aGVHD mouse model was successfully established, the intraperitoneal injection of BBG alleviated the aGVHD clinical manifestations including roachback, ruffled fur, skin peeling and weight loss of recipient mice, decreased P2X7R and IL-1beta expression and reduced the mRNA levels of P2X7R, NLRP3, Caspase-1, IL-1beta and IL-18.	coomassie Brilliant Blue	104-107	interleukin 1 beta	Mus musculus	331-339
28379583-10	2017	3) Morphine induces microglial activation, as evidenced by increased p38 MAPK phosphorylation, IBA1, and IL-1beta in the spinal cord, and these changes are inhibited by B vitamins.	Morphine	3-11	interleukin 1 beta	Mus musculus	105-113
28623824-8	2017	Mechanistically, nitrate treatment reduced renal superoxide generation, pro-inflammatory cytokines (IL-1beta, IL-6 and IL-12 p70) and macrophage infiltration in the kidney.	Nitrates	17-24	interleukin 1 beta	Mus musculus	100-108
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	14-31	interleukin 1 beta	Mus musculus	304-312
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	33-39	interleukin 1 beta	Mus musculus	304-312
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	Cholesterol	20-31	interleukin 1 beta	Mus musculus	304-312
29033950-4	2017	One group, mapping to innate immunity and antiviral responses (Oas2, Oas3, Mx2, Irf7, Irf9, STAT1, il1b), required GSH for optimal induction.	Glutathione	115-118	interleukin 1 beta	Mus musculus	99-103
29026299-6	2017	Animals treated with GSGNPs (10 mg/kg) and SGNPs (20 mg/kg) retained usual hepatic functions with routine levels of hepatobiliary enzymes (aspartate transferase, alanine transaminase, alkaline phosphatase, and lactate dehydrogenase) and inflammatory markers (interleukin-1beta and tumor necrosis factor-alpha) with minimal lipid peroxidation, whereas those treated with 100 mg/kg of Sly showed the similar effect.	gsgnps	21-27	interleukin 1 beta	Mus musculus	259-308
28836571-9	2017	CLI-095 or PDTC administration suppressed proinflammatory cytokine (TNF-alpha, IL-6, and IL-1beta) production and macrophage infiltration into the kidney (P &lt; 0.01).	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	0-7	interleukin 1 beta	Mus musculus	89-97
28946610-7	2017	Treatment with CR also reduced the heat stress-induced expression of nuclear factor kappa beta, tumor necrosis factor-alpha, and interleukin-1beta (IL-1beta) in the hippocampus.	Chromium	15-17	interleukin 1 beta	Mus musculus	129-146
28946610-7	2017	Treatment with CR also reduced the heat stress-induced expression of nuclear factor kappa beta, tumor necrosis factor-alpha, and interleukin-1beta (IL-1beta) in the hippocampus.	Chromium	15-17	interleukin 1 beta	Mus musculus	148-156
28766672-6	2017	The pretreatment with SP also markedly reduced the CCl4-induced expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), inducible nitric oxide synthase (iNOS) and nitric oxide (NO).	sp	22-24	interleukin 1 beta	Mus musculus	119-137
28766672-6	2017	The pretreatment with SP also markedly reduced the CCl4-induced expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), inducible nitric oxide synthase (iNOS) and nitric oxide (NO).	sp	22-24	interleukin 1 beta	Mus musculus	139-147
28836571-9	2017	CLI-095 or PDTC administration suppressed proinflammatory cytokine (TNF-alpha, IL-6, and IL-1beta) production and macrophage infiltration into the kidney (P &lt; 0.01).	pyrrolidine dithiocarbamic acid	11-15	interleukin 1 beta	Mus musculus	89-97
28554197-6	2017	The results indicated that balanophonin reduced not only the LPS-mediated TLR4 activation but also the production of inflammatory mediators, such as nitric oxide (NO), prostaglandin E2 (PGE2), Interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha), in BV2 cells.	balanophonin	27-39	interleukin 1 beta	Mus musculus	193-210
28893276-13	2017	The results were consistent with IMP blocking silica-induced phagolysosomal lysis, thereby preventing cell death and IL-1beta release.	Silicon Dioxide	46-52	interleukin 1 beta	Mus musculus	117-125
28617705-6	2017	GW3965 could inhibit the activation of glial cells and the expression of tumor necrosis factor-alpha (mean +- SD: 196 +- 48 vs. 119 +- 57; n = 6; P &lt; 0.01) and interleukin 1beta (mean +- SD: 215 +- 69 vs. 158 +- 74; n = 6; P &lt; 0.01) and increase the expression of interleukin 10 in the spinal dorsal horn.	GW 3965	0-6	interleukin 1 beta	Mus musculus	163-180
28655070-10	2017	In addition, the levels of TNF-alpha, IL-1beta, and Immunoglobulin-E in blood serum was significantly decreased in carnosol treated mice compared with those of 5% PA treated group.	carnosol	115-123	interleukin 1 beta	Mus musculus	38-46
28966615-5	2017	In mice with LPS, sodium propionate attenuates the LPS-induced histopathological changes, inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) production, myeloperoxidase activity in mammary tissues.	sodium propionate	18-35	interleukin 1 beta	Mus musculus	180-197
28966615-5	2017	In mice with LPS, sodium propionate attenuates the LPS-induced histopathological changes, inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) production, myeloperoxidase activity in mammary tissues.	sodium propionate	18-35	interleukin 1 beta	Mus musculus	199-207
28966615-9	2017	Finally, we examine the possibility that propionate acts as a histone deacetylase (HDAC) inhibitor, the results show that both sodium propionate and trichostatin A increase the level of histone H3 acetylation and inhibit the increased production of TNF-alpha, IL-6, and IL-1beta in LPS-stimulated mMECs.	Propionates	41-51	interleukin 1 beta	Mus musculus	270-278
28966615-9	2017	Finally, we examine the possibility that propionate acts as a histone deacetylase (HDAC) inhibitor, the results show that both sodium propionate and trichostatin A increase the level of histone H3 acetylation and inhibit the increased production of TNF-alpha, IL-6, and IL-1beta in LPS-stimulated mMECs.	sodium propionate	127-144	interleukin 1 beta	Mus musculus	270-278
28966615-9	2017	Finally, we examine the possibility that propionate acts as a histone deacetylase (HDAC) inhibitor, the results show that both sodium propionate and trichostatin A increase the level of histone H3 acetylation and inhibit the increased production of TNF-alpha, IL-6, and IL-1beta in LPS-stimulated mMECs.	trichostatin A	149-163	interleukin 1 beta	Mus musculus	270-278
28552908-11	2017	Furthermore, treatment with Xyl-B significantly attenuated ROS overproduction in brain tissues; increased the MnSOD protein levels, suppressed TLR4, NF-kappaB and iNOS protein levels; and downregulated the mRNA levels of proinflammatory cytokines, including IL-1beta, TNF-alpha, IL-6 and IFN-gamma.	xyloketal B	28-33	interleukin 1 beta	Mus musculus	258-266
28700976-6	2017	After coptisine treatment, the serum level of TC, TG and LDL-C decreased; the serum level of IL-6, IL-1beta and TNF-alpha were decreased; the mRNA levels of NF-kappaBp65, VCAM-1, ICAM-1, IL-6 and IL-1beta in both aorta and liver were down-regulated; the p-p38 and p-JNK1/2 protein expression level were decreased.	coptisine	6-15	interleukin 1 beta	Mus musculus	99-107
28700976-6	2017	After coptisine treatment, the serum level of TC, TG and LDL-C decreased; the serum level of IL-6, IL-1beta and TNF-alpha were decreased; the mRNA levels of NF-kappaBp65, VCAM-1, ICAM-1, IL-6 and IL-1beta in both aorta and liver were down-regulated; the p-p38 and p-JNK1/2 protein expression level were decreased.	coptisine	6-15	interleukin 1 beta	Mus musculus	196-204
28554197-6	2017	The results indicated that balanophonin reduced not only the LPS-mediated TLR4 activation but also the production of inflammatory mediators, such as nitric oxide (NO), prostaglandin E2 (PGE2), Interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha), in BV2 cells.	balanophonin	27-39	interleukin 1 beta	Mus musculus	212-220
28616865-8	2017	KEY RESULTS: Isoacteoside suppressed COX-2, iNOS, TNF-alpha, IL-6 and IL-1beta expression.	isoacteoside	13-25	interleukin 1 beta	Mus musculus	70-78
28962151-10	2017	It was found that hesperetin reduced the expression levels of TNF-alpha, IL-1beta, IL-6 and CTGF as well as collagen I and III.	hesperetin	18-28	interleukin 1 beta	Mus musculus	73-81
28947919-0	2017	Glucagon-like peptide-1 receptor agonist exendin-4 protects against interleukin-1beta-mediated inhibition of glucose-stimulated insulin secretion by mouse insulinoma beta cells.	Glucose	109-116	interleukin 1 beta	Mus musculus	68-85
28947919-1	2017	The aim of the present study was to investigate the protective effect of the glucagon-like peptide-1 receptor agonist exendin-4 on the interleukin (IL)-1beta-induced impairment of glucose-stimulated insulin secretion (GSIS) in beta-TC-6 cells.	beta-tc	227-234	interleukin 1 beta	Mus musculus	135-157
28668488-7	2017	Furthermore, GA obviously inhibited APAP-induced HMGB1-TLR4 signal activation, as evaluated by reduced hepatic HMGB1 release, p-IRAK1, p-MAPK and p-IkappaB expression as well as the productions of TNF-alpha and IL-1beta.	Acetaminophen	36-40	interleukin 1 beta	Mus musculus	211-219
28962181-6	2017	The results showed that administration of TUDCA attenuated liver pathological changes, reduced serum alanine aminotransferase and aspartate aminotransferase level, suppressed reactive oxygen species activity, decreased tumor necrosis factor-alpha and interleukin-1beta level and inhibited hepatocyte apoptosis induced by CIH.	ursodoxicoltaurine	42-47	interleukin 1 beta	Mus musculus	251-268
28644965-4	2017	In addition, DBL markedly reduced the total cell number, the leukocytes, the protein concentrations, and decreased the release of nitrite, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6 and the activities of matrix metalloproteinase (MMP)-2 and -9 in the bronchoalveolar lavage fluid.	disialyllactose	13-16	interleukin 1 beta	Mus musculus	174-196
29018785-7	2017	Lipopolysaccharide and glucose-induced nitric oxide production, protein expression of inducible nitric oxide synthase, COX-2, and superoxide dismutase 2, and mRNA expression levels of interleukin (IL)-1beta and IL-18 were significantly suppressed by turanose treatment.	Glucose	23-30	interleukin 1 beta	Mus musculus	184-206
28684418-8	2017	Greater reductions in HO-1 expression and increase in PGE2/IL-6 production were observed in HG+IL-1beta-stimulated chondrocytes from Nrf-2-/- mice than in chondrocytes from wild-type mice.	Dinoprostone	54-58	interleukin 1 beta	Mus musculus	95-103
28743082-6	2017	Carbon tetrachloride induced hepatic injury, observed through increased inflammatory markers (TNF-alpha, IL-1beta, PGE2, COX-2 and iNOS), changes in liver morphology, and increased serum levels of total cholesterol, triglycerides, TGO and TGP, LDL, as well as reduced HDL levels.	Carbon Tetrachloride	0-20	interleukin 1 beta	Mus musculus	105-113
29018785-7	2017	Lipopolysaccharide and glucose-induced nitric oxide production, protein expression of inducible nitric oxide synthase, COX-2, and superoxide dismutase 2, and mRNA expression levels of interleukin (IL)-1beta and IL-18 were significantly suppressed by turanose treatment.	turanose	250-258	interleukin 1 beta	Mus musculus	184-206
28271317-8	2017	AN680 (5 mg/kg) reduced DAI, colon shrinkage, weight loss, histopathological signs of colon damage, MPO activity, TNF-alpha, IL-1beta and IL-6 levels without inhibiting ChE.	an680	0-5	interleukin 1 beta	Mus musculus	125-133
28669709-0	2017	A mechanistic insight into curcumin modulation of the IL-1beta secretion and NLRP3 S-glutathionylation induced by needle-like cationic cellulose nanocrystals in myeloid cells.	Curcumin	27-35	interleukin 1 beta	Mus musculus	54-62
28854223-11	2017	Finally, treatment with TMSC[x4] significantly reversed the mRNA levels of IL-1beta and IL-6, although expression of all pro-inflammatory cytokines tested was induced in colitis mice.	tmsc	24-28	interleukin 1 beta	Mus musculus	75-83
28814068-4	2017	RESULTS: NAC and caspase-1 inhibitor suppressed CSE- and DEP-induced secretion of IL-1beta in RAW 264.7 cells.	Acetylcysteine	9-12	interleukin 1 beta	Mus musculus	82-90
28814068-8	2017	NAC inhibited CSE- and DEP-induced IL-1beta secretion in both the normal and elastase-induced emphysema groups.	Acetylcysteine	0-3	interleukin 1 beta	Mus musculus	35-43
28666844-6	2017	EsA also inhibited LPS-induced TNF-alpha, IL-1beta, and IL-6 production.	esculentoside A	0-3	interleukin 1 beta	Mus musculus	42-50
28731262-6	2017	GFA also inhibited the increase in serum tumour necrosis factor-alpha and interleukin-1beta induced by cisplatin.	Cisplatin	103-112	interleukin 1 beta	Mus musculus	74-91
28647362-6	2017	Interesting, GW4064 suppresses NACHT, LRR and PYD domains-containing protein 3 (NALP3) inflammasome mediates tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and IL-1beta, as well as mitochondrial respiratory complexes mRNA expression in WT and FXR KO mice treated with LPS.	GW 4064	13-19	interleukin 1 beta	Mus musculus	173-181
28693884-7	2017	Rutin also induced a decrease in the mRNA levels of TNF, IL1beta, IL6 and iNOS, reduced the production of IL6, TNF, and nitric oxide, and increased production of the M2 regulatory cytokine IL10 and arginase.	Rutin	0-5	interleukin 1 beta	Mus musculus	57-64
28669709-1	2017	Recently we have demonstrated that needle-like cationic cellulose nanocrystals (CNC-AEMA2) evoke immunological responses through NLRP3 inflammasome/IL-1beta inflammatory pathway.	Cellulose	56-65	interleukin 1 beta	Mus musculus	148-156
28669709-2	2017	In this study we demonstrated that curcumin, a naturally occurring polyphenolic compound isolated from Curcuma longa (Zingiberaceae), was able to suppress, at least in part, this immunological response, as observed by diminished IL-1beta secretion in CNC-AEMA2-stimulated macrophages primed with LPS.	Curcumin	35-43	interleukin 1 beta	Mus musculus	229-237
28890700-12	2017	Finally, the low- and high-capsaicin diets significantly increased the fecal butyrate and plasma total GLP-1 levels, but decreased plasma total ghrelin, TNF-alpha, IL-1beta, and IL-6 levels as compared with the normal diet.	Capsaicin	27-36	interleukin 1 beta	Mus musculus	164-172
28669709-5	2017	We hypothesize that curcumin may also affect S-glutathionylation of key proteins involved in the NLRP3 inflammasome/IL-1beta pathway, and therefore impact their protein-protein interactions.	Curcumin	20-28	interleukin 1 beta	Mus musculus	116-124
28669709-8	2017	Taking together, our results suggest that, at least in part, the anti-inflammatory activity of curcumin is associated with changes in S-glutathionylation of key NLRP3 inflammasome components, and perhaps resulting in sustained complex assembly and suppression of IL-1beta secretion.	Curcumin	95-103	interleukin 1 beta	Mus musculus	263-271
28839206-6	2017	In in vitro experiments, GSP dose-dependently inhibited mRNA expression of interleukin (IL)-1beta, IL-6 and monocyte chemoattractant protein-1 (MCP-1), and significantly inhibited expression and activity of MMP-2 and MMP-9, thus prevented elastin from degradation.	gamma-Thio-GTP	25-28	interleukin 1 beta	Mus musculus	75-97
29109767-5	2017	Then, the efficacy of DEX-SPNs is tested in vitro over macrophages and in vivo by monitoring the animal weight, food and water intake; expression of inflammatory cytokines (TNF-alpha, IL-1beta, IL-6); intestinal density of macrophages; rectal bleeding and histological scoring.	dex-spns	22-30	interleukin 1 beta	Mus musculus	184-192
28861518-7	2017	Infected mice administered butyrate displayed elevated expression of genes necessary for pathogen clearance (i.e., Il17A and Il1beta) and of genes involved in epithelial barrier repair and restoration (i.e., Relmbeta, Tff3, and Myd88).	Butyrates	27-35	interleukin 1 beta	Mus musculus	125-132
28871223-3	2017	The LMWH product depolymerized by Heparinase I (I-11) with a Mw of 7160, exhibited a significant advantage in reducing the liver inflammation by suppressing TNF-alpha and IL-1beta secretion, and minimizing hepatic fibrogenesis.	Heparin, Low-Molecular-Weight	4-8	interleukin 1 beta	Mus musculus	171-179
28817116-4	2017	TTN suppressed the expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the secretion of TNF-alpha, IL-6, and IL-1beta in RAW264.7 cells, bone marrow-derived macrophages, and THP-1 cells.	Tartronic acid	0-3	interleukin 1 beta	Mus musculus	143-151
28478040-9	2017	Importantly, DOCA/salt-induced cardiac fibrosis, inflammation and the expression of collagen I, collagen III, alpha-SMA, IL-1beta, IL-6 and TNF-alpha in the wild-type hearts, which were markedly attenuated by beta2i knockout.	Desoxycorticosterone Acetate	13-17	interleukin 1 beta	Mus musculus	121-129
28478040-9	2017	Importantly, DOCA/salt-induced cardiac fibrosis, inflammation and the expression of collagen I, collagen III, alpha-SMA, IL-1beta, IL-6 and TNF-alpha in the wild-type hearts, which were markedly attenuated by beta2i knockout.	Salts	18-22	interleukin 1 beta	Mus musculus	121-129
28726961-7	2017	Furthermore, the levels of oxidative stress, tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta are all reduced significantly in PD mice and the CAR-25 mg kg-1 DA group in comparison with that in 6-OHDA-lesioned mice with saline and 6-OHDA-lesioned mice, as well as the Tyrosine hydroxylase-immunoreactive (TH-ir) density increased (p &lt; 0.01).	Sodium Chloride	232-238	interleukin 1 beta	Mus musculus	83-105
28554806-10	2017	BBG and PPADS led to an increase of TNF-alpha and IL-1beta in the nerve on day 1 and PPADS caused a decrease of IL-1beta on day 7.	coomassie Brilliant Blue	0-3	interleukin 1 beta	Mus musculus	50-58
28554806-10	2017	BBG and PPADS led to an increase of TNF-alpha and IL-1beta in the nerve on day 1 and PPADS caused a decrease of IL-1beta on day 7.	coomassie Brilliant Blue	0-3	interleukin 1 beta	Mus musculus	112-120
28797292-9	2017	ALE also significantly normalized the stress-induced activation of astrocytes and microglial cells in the hippocampus as well as the elevation of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta).	Epinephrine	0-3	interleukin 1 beta	Mus musculus	226-244
28797292-9	2017	ALE also significantly normalized the stress-induced activation of astrocytes and microglial cells in the hippocampus as well as the elevation of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta).	Epinephrine	0-3	interleukin 1 beta	Mus musculus	246-254
29050341-4	2017	In vivo, GOH treatment markedly ameliorated pathological injury and pulmonary cell apoptosis and reduced the wet/dry (W/D) weight ratio of lungs, myeloperoxidase (MPO) activity and the production of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha).	5-[2-Cyclopropyl-5-(1h-Pyrrol-1-Yl)-1,3-Oxazol-4-Yl]-1h-1,2,3,4-Tetrazole	9-12	interleukin 1 beta	Mus musculus	227-235
28848393-9	2017	The P2X7 receptor was implicated in the mechanosensitive priming of IL-1beta mRNA in vivo, as the antagonist Brilliant Blue G (BBG) blocked the increased expression, the agonist BzATP mimicked the pressure-dependent rise in IL-1beta, and the rise was absent in P2X7 knockout mice.	coomassie Brilliant Blue	109-125	interleukin 1 beta	Mus musculus	68-76
28848393-9	2017	The P2X7 receptor was implicated in the mechanosensitive priming of IL-1beta mRNA in vivo, as the antagonist Brilliant Blue G (BBG) blocked the increased expression, the agonist BzATP mimicked the pressure-dependent rise in IL-1beta, and the rise was absent in P2X7 knockout mice.	coomassie Brilliant Blue	127-130	interleukin 1 beta	Mus musculus	68-76
28848393-9	2017	The P2X7 receptor was implicated in the mechanosensitive priming of IL-1beta mRNA in vivo, as the antagonist Brilliant Blue G (BBG) blocked the increased expression, the agonist BzATP mimicked the pressure-dependent rise in IL-1beta, and the rise was absent in P2X7 knockout mice.	coomassie Brilliant Blue	127-130	interleukin 1 beta	Mus musculus	224-232
28848393-9	2017	The P2X7 receptor was implicated in the mechanosensitive priming of IL-1beta mRNA in vivo, as the antagonist Brilliant Blue G (BBG) blocked the increased expression, the agonist BzATP mimicked the pressure-dependent rise in IL-1beta, and the rise was absent in P2X7 knockout mice.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	178-183	interleukin 1 beta	Mus musculus	68-76
28848393-11	2017	This increase in IL-1beta was eliminated by degradation of extracellular ATP with apyrase, or by the block of pannexin hemichannels with carbenoxolone, probenecid, or 10panx1 peptide.	Carbenoxolone	137-150	interleukin 1 beta	Mus musculus	17-25
28848393-11	2017	This increase in IL-1beta was eliminated by degradation of extracellular ATP with apyrase, or by the block of pannexin hemichannels with carbenoxolone, probenecid, or 10panx1 peptide.	Probenecid	152-162	interleukin 1 beta	Mus musculus	17-25
28848393-12	2017	The rise in IL-1beta expression was also blocked by P2X7 receptor antagonists BBG, A839977 or A740003.	coomassie Brilliant Blue	78-81	interleukin 1 beta	Mus musculus	12-20
28848393-13	2017	The rise in IL-1beta was prevented by blocking transcription factor NFkappaB with Bay 11-7082, while the swelling-dependent fall in NFkappaB inhibitor IkappaB-alpha was reduced by A839977 and in P2X7 knockout mice.	3-(4-methylphenylsulfonyl)-2-propenenitrile	82-93	interleukin 1 beta	Mus musculus	12-20
28848394-7	2017	Further, Resveratrol treated mice exhibited improved hematoma resolution with a concomitant reduction in the expression of proinflammatory cytokine, IL-1beta after ICH.	Resveratrol	9-20	interleukin 1 beta	Mus musculus	149-157
28777298-5	2017	Short-term luseogliflozin treatment normalized the expression of inflammation-related genes such as F4/80, TNFalpha, IL-1beta, IL-6, ICAM-1, PECAM-1, MMP2 and MMP9 in the NA/STZ-treated ApoE KO mice, which showed marked elevations as compared with untreated ApoE KO mice.	1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol	11-25	interleukin 1 beta	Mus musculus	117-125
28726961-7	2017	Furthermore, the levels of oxidative stress, tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta are all reduced significantly in PD mice and the CAR-25 mg kg-1 DA group in comparison with that in 6-OHDA-lesioned mice with saline and 6-OHDA-lesioned mice, as well as the Tyrosine hydroxylase-immunoreactive (TH-ir) density increased (p &lt; 0.01).	Oxidopamine	243-249	interleukin 1 beta	Mus musculus	83-105
28522560-10	2017	Maternal MitoQ treatment normalized RAGE, IL-1beta, and Nrf-2 levels in the SE + MQ offspring.	mitoquinone	9-14	interleukin 1 beta	Mus musculus	42-50
28603288-6	2017	In mouse peritoneal macrophages, pretreatment with osthole (50 mumol/L) significantly attenuated the LPS-induced elevation of cytokines at the mRNA level; inhibition of PKA completely reversed the inhibitory effects of osthole on IL-1beta, IL-6, COX2, and MCP-1 but not on TNFalpha.	osthol	51-58	interleukin 1 beta	Mus musculus	230-238
28603288-8	2017	Moreover, in LPS-stimulated mouse peritoneal macrophages, SB203580 strongly inhibited the restored expression of IL-1beta, IL-6, COX2, and MCP-1, which was achieved by abolishing the suppressive effects of osthole with the PKA inhibitors.	SB 203580	58-66	interleukin 1 beta	Mus musculus	113-121
28603288-8	2017	Moreover, in LPS-stimulated mouse peritoneal macrophages, SB203580 strongly inhibited the restored expression of IL-1beta, IL-6, COX2, and MCP-1, which was achieved by abolishing the suppressive effects of osthole with the PKA inhibitors.	osthol	206-213	interleukin 1 beta	Mus musculus	113-121
29044426-1	2017	The P2X7 is an adenosine triphosphate (ATP)-gated ion channel involved in several facets of immune activation and neuronal function through its importance in interleukin (IL)-1beta secretion.	Adenosine Triphosphate	15-37	interleukin 1 beta	Mus musculus	158-180
28596375-6	2017	Bone marrow-derived macrophages and dendritic cells were stimulated with lipopolysaccharide and cholesterol crystals resulting in high levels of interleukin-1beta release, which was inhibited by MCC950.	Cholesterol	96-107	interleukin 1 beta	Mus musculus	145-162
28252317-12	2017	Treatment with anti-IL-1beta, Ac-YVAD-cho, and MCC950 suppressed IL-1beta responses and the important steroid-resistant features of disease in mice, whereas IL-1beta administration recapitulated these features.	L 709049	30-41	interleukin 1 beta	Mus musculus	65-73
28252317-12	2017	Treatment with anti-IL-1beta, Ac-YVAD-cho, and MCC950 suppressed IL-1beta responses and the important steroid-resistant features of disease in mice, whereas IL-1beta administration recapitulated these features.	L 709049	30-41	interleukin 1 beta	Mus musculus	65-73
28252317-12	2017	Treatment with anti-IL-1beta, Ac-YVAD-cho, and MCC950 suppressed IL-1beta responses and the important steroid-resistant features of disease in mice, whereas IL-1beta administration recapitulated these features.	Steroids	102-109	interleukin 1 beta	Mus musculus	20-28
29044426-1	2017	The P2X7 is an adenosine triphosphate (ATP)-gated ion channel involved in several facets of immune activation and neuronal function through its importance in interleukin (IL)-1beta secretion.	Adenosine Triphosphate	39-42	interleukin 1 beta	Mus musculus	158-180
28939019-13	2017	In MSU crystals-induced ankle arthritic mouse model, administration of MEMH relieved inflammatory symptoms and decreased the plasma levels of IL-1beta and TNFalpha.	memh	71-75	interleukin 1 beta	Mus musculus	142-150
28625489-9	2017	Single treatment with diosmin inhibited in a dose-dependent manner CCI-induced mechanical and thermal hyperalgesia by activating the NO/cGMP/PKG/KATP channel signaling pathway and inhibiting spinal cord cytokine (Il-1beta and Il-33/St2) and glial cells activation (microglia - Iba-1, oligodendrocytes - Olig2) mRNA expression markers.	Diosmin	22-29	interleukin 1 beta	Mus musculus	213-221
28625489-9	2017	Single treatment with diosmin inhibited in a dose-dependent manner CCI-induced mechanical and thermal hyperalgesia by activating the NO/cGMP/PKG/KATP channel signaling pathway and inhibiting spinal cord cytokine (Il-1beta and Il-33/St2) and glial cells activation (microglia - Iba-1, oligodendrocytes - Olig2) mRNA expression markers.	CCI	67-70	interleukin 1 beta	Mus musculus	213-221
28625489-10	2017	Daily treatment during 7 days with diosmin inhibited CCI-induced mechanical and thermal hyperalgesia by inhibiting spinal cord cytokine (Il-1beta, Tnfalpha, and Il-33/St2) and glial cells activation (astrocytes - Gfap, Iba-1, and Olig2) markers mRNA expression.	Diosmin	35-42	interleukin 1 beta	Mus musculus	137-145
28625489-10	2017	Daily treatment during 7 days with diosmin inhibited CCI-induced mechanical and thermal hyperalgesia by inhibiting spinal cord cytokine (Il-1beta, Tnfalpha, and Il-33/St2) and glial cells activation (astrocytes - Gfap, Iba-1, and Olig2) markers mRNA expression.	CCI	53-56	interleukin 1 beta	Mus musculus	137-145
28438557-5	2017	ABI-4 (0.32mg/kg) blocked LPS-induced release of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) in blood and brain of mice.	abi-4	0-5	interleukin 1 beta	Mus musculus	88-96
28438557-10	2017	Aged mice dosed chronically with ABI-4 (0.32mg/kg) as well as aged PDE4B-/- mice, had significantly lower levels of TNF-alpha and IL-1beta in brain and plasma relative to vehicle treated or PDE4+/+ mice.	abi-4	33-38	interleukin 1 beta	Mus musculus	130-138
28810554-8	2017	Furthermore, IL-1beta levels in the PCP-treated groups were lower than those in the UVB-exposed control group.	pcp	36-39	interleukin 1 beta	Mus musculus	13-21
28493080-10	2017	Honokiol significantly inhibited leukocyte infiltration and upregulation of proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6) and inducible nitric oxide synthase in the ileal muscle layer of postoperative ileus model mice.	honokiol	0-8	interleukin 1 beta	Mus musculus	132-149
28495847-3	2017	Interleukin (IL)-1beta content of MPs also increases after 2,000 ppm by 3.8 +- 0.6-fold (n = 6) and after 4,000 ppm CO2 by 9.3 +- 1.1-fold (n = 10) greater than control.	Carbon Dioxide	116-119	interleukin 1 beta	Mus musculus	0-22
28595079-6	2017	Furthermore, curcumin markedly decreased NAD(P)H oxidase subunits (p67phox, p47phox, p22phox), nitrotyrosine and CYP2E1 renal protein expression as well as reduced pro-inflammatory cytokine expression (TNFalpha, IL-1beta, IFNgamma).	Curcumin	13-21	interleukin 1 beta	Mus musculus	212-220
28558302-5	2017	After administration of EGCG, the number of sneezes and the occurrence of nasal rubbing were significantly decreased, the concentrations of immunoglobulin E (IgE) and histamine were suppressed in AR mouse serum, the levels of interleukin (IL)-1beta, IL-4, and IL-6 were reduced in AR mice nasal lavage fluid (NLF), and the nasal mucosa mRNA and protein expression of cyclooxygenase 2 (COX-2), IL-1beta, IL-4, and IL-6 were inhibited.	epigallocatechin gallate	24-28	interleukin 1 beta	Mus musculus	393-401
28577437-12	2017	In addition, rutin was shown to repress the autophagic function of liver tissues by down-regulating key autophagy biomarkers, including tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta).	Rutin	13-18	interleukin 1 beta	Mus musculus	177-195
28577437-12	2017	In addition, rutin was shown to repress the autophagic function of liver tissues by down-regulating key autophagy biomarkers, including tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta).	Rutin	13-18	interleukin 1 beta	Mus musculus	197-205
28495847-4	2017	CO2-induced vascular damage is abrogated by treating mice with an antibody to IL-1beta or an IL-1beta receptor inhibitor.	Carbon Dioxide	0-3	interleukin 1 beta	Mus musculus	78-86
28495847-4	2017	CO2-induced vascular damage is abrogated by treating mice with an antibody to IL-1beta or an IL-1beta receptor inhibitor.	Carbon Dioxide	0-3	interleukin 1 beta	Mus musculus	93-101
28495847-6	2017	We conclude that environmentally relevant elevations of CO2 trigger neutrophils to generate MPs containing high concentrations of IL-1beta that cause diffuse inflammatory vascular injury.NEW &amp; NOTEWORTHY Elevated levels of CO2 are often found in indoor air and cause adverse health effects, but the mechanisms have not been identified.	Carbon Dioxide	56-59	interleukin 1 beta	Mus musculus	130-138
28495847-6	2017	We conclude that environmentally relevant elevations of CO2 trigger neutrophils to generate MPs containing high concentrations of IL-1beta that cause diffuse inflammatory vascular injury.NEW &amp; NOTEWORTHY Elevated levels of CO2 are often found in indoor air and cause adverse health effects, but the mechanisms have not been identified.	Adenosine Monophosphate	192-195	interleukin 1 beta	Mus musculus	130-138
28495847-6	2017	We conclude that environmentally relevant elevations of CO2 trigger neutrophils to generate MPs containing high concentrations of IL-1beta that cause diffuse inflammatory vascular injury.NEW &amp; NOTEWORTHY Elevated levels of CO2 are often found in indoor air and cause adverse health effects, but the mechanisms have not been identified.	Carbon Dioxide	227-230	interleukin 1 beta	Mus musculus	130-138
28495847-7	2017	In a murine model, environmentally relevant levels of CO2 were found to cause diffuse vascular damage because neutrophils are stimulated to produce microparticles that contain high concentrations of interleukin-1beta.	Carbon Dioxide	54-57	interleukin 1 beta	Mus musculus	199-216
28500787-9	2017	CPO and DFP alone caused cortical and hippocampal neuroinflammation assessed by qPCR of tumor necrosis factor-alpha, IL-6, C-C chemokine ligand 2, IL-1beta, leukemia inhibitory factor and oncostatin M; CORT pretreatment markedly augmented these effects.	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	0-3	interleukin 1 beta	Mus musculus	147-155
28303409-3	2017	We report herein that db/db mice concomitantly fed the Western diet and treated with the anti-inflammatory agent methotrexate display a less aggressive inflammatory (lower serum IL-1beta, IL-6, SDF-1, and TNFalpha levels; higher circulating adiponectin, IL-12p70 and IL-10 concentrations; lower aortic VCAM-1 levels) profile than their saline-treated counterpart.	Methotrexate	113-125	interleukin 1 beta	Mus musculus	178-186
28844021-6	2017	Cells transfected with TRIF, TRAF6, RIP1 or TAK1 all decreased production of poly(I:C)-induced IL-1alpha, IL-1beta, IL-6, GRO-alpha, IL-8, MCP-1, ICAM-1 and MMP-9 expression.	Poly I-C	77-86	interleukin 1 beta	Mus musculus	106-114
28805975-5	2017	Antofine significantly suppressed the secretion of proinflammatory cytokines such as TNFalpha and IL-1beta and the production of iNOS in LPS-activated Raw264.7 macrophage cells.	antofine	0-8	interleukin 1 beta	Mus musculus	98-106
28404518-4	2017	Immunohistochemistry showed similar massive IBA1 positive macrophage infiltration surrounding implanted disk material among groups, but IL-1beta and IL-6 expression was decreased in the fullerol treated group.	fullerol	186-194	interleukin 1 beta	Mus musculus	136-144
28404518-5	2017	In the DRG explant culture, after treatment with TNF-alpha, the expression of IL-1beta, NLRP3, and caspase 1 was significantly increased but this was reversed by the addition of fullerol.	fullerol	178-186	interleukin 1 beta	Mus musculus	78-86
28378105-6	2017	In the media of brain microvascular endothelial cells (BMECs), oxygen and glucose deprivation-reperfusion (OGD-R) could remarkably lead to the elevation of TNF-alpha and IL-1beta levels, while magnolol evidently reversed these effects.	Oxygen	63-69	interleukin 1 beta	Mus musculus	170-178
28645584-14	2017	IL-1beta increase in BAL fluid was abolished by both GYY4137 and NaHS treatments whereas TNF-alpha levels remained unchanged.	GYY 4137	53-60	interleukin 1 beta	Mus musculus	0-8
28463821-4	2017	Here we show that long-term ethanol exposure of human peripheral blood mononuclear cells and a mouse macrophage cell line (J774) amplifies IL-1beta secretion following stimulation with NLRP3 agonists, but not with AIM2 or NLRP1b agonists.	Ethanol	28-35	interleukin 1 beta	Mus musculus	139-147
28645584-14	2017	IL-1beta increase in BAL fluid was abolished by both GYY4137 and NaHS treatments whereas TNF-alpha levels remained unchanged.	sodium bisulfide	65-69	interleukin 1 beta	Mus musculus	0-8
28463821-8	2017	Together, these results indicate that increases in iNOS and mitochondrial ROS production are critical for chronic ethanol-induced IL-1beta hypersecretion, and that protracted exposure to the products of ethanol metabolism are probable mediators of NLRP3 inflammasome hyperactivation.	Ethanol	114-121	interleukin 1 beta	Mus musculus	130-138
28791016-0	2017	Doxycycline Attenuates Leptospira-Induced IL-1beta by Suppressing NLRP3 Inflammasome Priming.	Doxycycline	0-11	interleukin 1 beta	Mus musculus	42-50
28765650-6	2017	This decrease was associated with an inhibition of the activation of p38MAPK, JNK, NF-kappaB and NLRP3 inflammasome leading to a reduction of IL-1beta secretion in response to LPS and ATP in REDD1-/- BMDM.	Adenosine Triphosphate	184-187	interleukin 1 beta	Mus musculus	142-150
28551404-7	2017	In an LPS-challenged mouse model, harmine markedly averted inflammatory damage of the lung, and decreased serum TNF-alpha, interleukin-1beta (IL-1beta) and IL-6 levels.	Harmine	34-41	interleukin 1 beta	Mus musculus	123-140
28551404-7	2017	In an LPS-challenged mouse model, harmine markedly averted inflammatory damage of the lung, and decreased serum TNF-alpha, interleukin-1beta (IL-1beta) and IL-6 levels.	Harmine	34-41	interleukin 1 beta	Mus musculus	142-150
28738878-9	2017	RESULTS: We show that alcohol intake during gestation and lactation increases the levels of several cytokines/chemokines (IL-1beta, IL-17, MIP-1alpha, and fractalkine) in the maternal sera, amniotic fluid, and brains of fetuses and offspring.	Alcohols	22-29	interleukin 1 beta	Mus musculus	122-130
28431044-8	2017	Results: Leonurine treatment significantly decreased the production of pro-inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNFalpha) and MMPs (MMP-1 and MMP-3) and suppressed the migration and invasion of RA fibroblast-like synoviocytes.	leonurine	9-18	interleukin 1 beta	Mus musculus	99-107
28759565-4	2017	Only DCs matured under CThi conditions secreted IL-1beta, IL-6 and IL-23 leading to the instruction of Th17 cell polarization.	cthi	23-27	interleukin 1 beta	Mus musculus	48-56
28754131-10	2017	In addition, etifoxine treatment led to decreased expression of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, and inducible nitric oxide synthase by microglia.	etifoxine	13-22	interleukin 1 beta	Mus musculus	64-81
28791016-4	2017	Using J774A.1 mouse macrophages, the effects of Dox on protein and mRNA levels of IL-1beta and TNF-alpha were investigated after infection with live or sonicated Leptospira interrogans serovar Lai strain Lai (56601).	Doxycycline	48-51	interleukin 1 beta	Mus musculus	82-90
28791016-5	2017	Specifically, the level of IL-1beta but not TNF-alpha was sharply decreased when treated with Dox in leptospira-infected macrophages.	Doxycycline	94-97	interleukin 1 beta	Mus musculus	27-35
28791016-9	2017	The inhibition effect of Dox on IL-1beta was also conspicuous in cells with lipopolysaccharide and ATP stimulation.	Doxycycline	25-28	interleukin 1 beta	Mus musculus	32-40
28791016-9	2017	The inhibition effect of Dox on IL-1beta was also conspicuous in cells with lipopolysaccharide and ATP stimulation.	Adenosine Triphosphate	99-102	interleukin 1 beta	Mus musculus	32-40
28791016-10	2017	These results were confirmed in vivo, as peritoneal fluids of mice and organs of hamsters expressed less IL-1beta after treatment of leptospiral infection with Dox.	Doxycycline	160-163	interleukin 1 beta	Mus musculus	105-113
28791016-11	2017	Our results indicated that Dox also modulated immune response to attenuate leptospira-induced IL-1beta by suppressing p38, JNK, p65, and NLRP3 inflammasome priming.	Doxycycline	27-30	interleukin 1 beta	Mus musculus	94-102
28641003-5	2017	Generally, a range of ortho-amidated benzaldehydes displayed promising inhibitory activity against IL-1beta and TNF-alpha compared to dexamethasone as a positive control.	Benzaldehydes	37-50	interleukin 1 beta	Mus musculus	99-107
28938606-4	2017	The production of IL-1beta, IL-6 and TNF-alpha in colon was also markedly reduced by oroxylin A.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	85-95	interleukin 1 beta	Mus musculus	18-26
28938606-7	2017	Further study found that the activation of NLRP3 inflammasome was dose-dependently inhibited by oroxylin A in both THP-Ms and BMDMs, followed by decrease in the cleavage of caspase-1 and secretion of IL-1beta.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	96-106	interleukin 1 beta	Mus musculus	200-208
28576828-7	2017	In LPS/ATP-stimulated bone marrow-derived macrophages (BMDMs), CLIC1 or CLIC4 siRNA transfection impaired transcription of IL-1beta, ASC speck formation, and secretion of mature IL-1beta.	Adenosine Triphosphate	7-10	interleukin 1 beta	Mus musculus	123-131
28576828-7	2017	In LPS/ATP-stimulated bone marrow-derived macrophages (BMDMs), CLIC1 or CLIC4 siRNA transfection impaired transcription of IL-1beta, ASC speck formation, and secretion of mature IL-1beta.	Adenosine Triphosphate	7-10	interleukin 1 beta	Mus musculus	178-186
28695925-6	2017	In addition, AG inhibited the production of pro-inflammatory cytokines, such as TNF-alpha, IL-1beta, and IL-6, and the protein expression of COX-2 and iNOS in mice with DSS-induced colitis.	Dextran Sulfate	169-172	interleukin 1 beta	Mus musculus	91-99
28726741-5	2017	Moreover, colonic pro-inflammatory cytokines (TNF-alpha, IL-6, and IL-1beta) induced by colitis were dramatically decreased by magnolol.	magnolol	127-135	interleukin 1 beta	Mus musculus	67-75
28716092-11	2017	Third, BzATP-induced release of IL1 family cytokines including IL1alpha, IL1beta, and IL18 was blocked in P2X7-/- microglia or by A-804598 in pro-inflammatory microglia, while the release of other cytokines/chemokines was independent of P2X7 activation.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	7-12	interleukin 1 beta	Mus musculus	73-80
28725182-5	2017	In peripheral blood mononuclear cells from nAChR gene-deficient mice, we demonstrated that inhibition of ATP-dependent release of IL-1beta by acetylcholine (ACh), nicotine and PC depends on subunits alpha7, alpha9 and alpha10.	Adenosine Triphosphate	105-108	interleukin 1 beta	Mus musculus	130-138
28725182-5	2017	In peripheral blood mononuclear cells from nAChR gene-deficient mice, we demonstrated that inhibition of ATP-dependent release of IL-1beta by acetylcholine (ACh), nicotine and PC depends on subunits alpha7, alpha9 and alpha10.	Acetylcholine	142-155	interleukin 1 beta	Mus musculus	130-138
28725182-5	2017	In peripheral blood mononuclear cells from nAChR gene-deficient mice, we demonstrated that inhibition of ATP-dependent release of IL-1beta by acetylcholine (ACh), nicotine and PC depends on subunits alpha7, alpha9 and alpha10.	Acetylcholine	44-47	interleukin 1 beta	Mus musculus	130-138
28725182-5	2017	In peripheral blood mononuclear cells from nAChR gene-deficient mice, we demonstrated that inhibition of ATP-dependent release of IL-1beta by acetylcholine (ACh), nicotine and PC depends on subunits alpha7, alpha9 and alpha10.	Nicotine	163-171	interleukin 1 beta	Mus musculus	130-138
28725182-5	2017	In peripheral blood mononuclear cells from nAChR gene-deficient mice, we demonstrated that inhibition of ATP-dependent release of IL-1beta by acetylcholine (ACh), nicotine and PC depends on subunits alpha7, alpha9 and alpha10.	Phosphorylcholine	176-178	interleukin 1 beta	Mus musculus	130-138
28336494-8	2017	In the hippocampus, minocycline reversed the increases in the levels of interleukin (IL-1beta), Tumor Necrosis Factor- alpha (TNF-alpha) and, IL-10 caused by Abeta (1-42).	Minocycline	20-31	interleukin 1 beta	Mus musculus	85-93
28276710-6	2017	The gene expression of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and COX2, significantly increased in the cerebrum of KBrO3-treated group.	kbro3	138-143	interleukin 1 beta	Mus musculus	52-69
28345393-0	2017	Inhibitory effects of 3alpha-hydroxy-lup-20(29)-en-23, 28-dioic acid on lipopolysaccharide-induced TNF-alpha, IL-1beta, and the high mobility group box 1 release in macrophages.	3alpha-hydroxy-lup-20(29)-en-23, 28-dioic acid	22-68	interleukin 1 beta	Mus musculus	110-118
28320049-7	2017	DBHB treatment suppressed SCI-induced NLRP3 inflammasome activation and reduced protein expression of IL-1beta and IL-18.	DBHB	0-4	interleukin 1 beta	Mus musculus	102-110
28370033-4	2017	Under defined ELF-EMF exposure conditions, the production of nitric oxide and pro-inflammatory cytokines, TNF-alpha, IL-1beta, and IL-6, were increased in RAW 264.7 cells and the expression of those genes was also upregulated.	Nitric Oxide	61-73	interleukin 1 beta	Mus musculus	117-125
28477462-8	2017	Melatonin (20mg/kg, p.o) treatment for 14days significantly prevented the raised oxidative stress, release of IL-1beta, GSH depletion and augmentation of AChE activity in the hippocampus.	Melatonin	0-9	interleukin 1 beta	Mus musculus	110-118
28478865-7	2017	Compound IIh also suppressed the induction of the pro-inflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in LPS-stimulated RAW 264.7 cells.	4-(7-Chloro-1,3-Benzoxazol-2-Yl)-2,6-Diiodophenol	9-12	interleukin 1 beta	Mus musculus	109-126
28861878-1	2017	In mice, two-hour immobilization stress inhibited zymosan-induced production by macrophages of the oxygen radicals and cytokine IL-1beta.	Zymosan	50-57	interleukin 1 beta	Mus musculus	128-136
28251819-6	2017	Additionally, we found that the mRNA levels of the pro-inflammatory factors IL-1beta, IL-6, CXCL-1, and TNF-alpha, in peritoneal macrophages, the spleen, and the thymus were inhibited in the cis-BF-treated groups.	cis-bf	191-197	interleukin 1 beta	Mus musculus	76-84
28750561-8	2017	It also inhibited cisplatin-induced overproduction of kidney injury molecule-1 (KIM-1), malondialdehyde (MDA), tumour necrosis factor-alpha (TNF - alpha), and interleukin-1beta (IL-1beta) in kidney tissues.	Cisplatin	18-27	interleukin 1 beta	Mus musculus	159-176
28750561-8	2017	It also inhibited cisplatin-induced overproduction of kidney injury molecule-1 (KIM-1), malondialdehyde (MDA), tumour necrosis factor-alpha (TNF - alpha), and interleukin-1beta (IL-1beta) in kidney tissues.	Cisplatin	18-27	interleukin 1 beta	Mus musculus	178-186
28776450-8	2017	Aminoguanidine preserved lung function and shifted the Th2 to the Th1 response with a reduction of IL-4 and IL-13 and increase in IL-1beta production.	pimagedine	0-14	interleukin 1 beta	Mus musculus	130-138
28504656-5	2017	We report that polyplexes made with a histidinylated derivative of lPEI (His-lPEI) exhibit the highest capacity (10.5 mug cm-2 h versus 0.324 mug cm-2 h) to cross TNF-alpha-induced inflamed endothelium model, but this positive effect is counterbalanced by the presence of IL-1beta.	lpei	67-71	interleukin 1 beta	Mus musculus	272-280
28486213-6	2017	The results showed that corynoline markedly inhibited LPS-induced neutrophils influx, MPO activity, and inflammatory cytokines IL-1beta, TNF-alpha and IL-6 release.	corynoline	24-34	interleukin 1 beta	Mus musculus	127-135
28504656-5	2017	We report that polyplexes made with a histidinylated derivative of lPEI (His-lPEI) exhibit the highest capacity (10.5 mug cm-2 h versus 0.324 mug cm-2 h) to cross TNF-alpha-induced inflamed endothelium model, but this positive effect is counterbalanced by the presence of IL-1beta.	Histidine	73-76	interleukin 1 beta	Mus musculus	272-280
28504656-5	2017	We report that polyplexes made with a histidinylated derivative of lPEI (His-lPEI) exhibit the highest capacity (10.5 mug cm-2 h versus 0.324 mug cm-2 h) to cross TNF-alpha-induced inflamed endothelium model, but this positive effect is counterbalanced by the presence of IL-1beta.	lpei	77-81	interleukin 1 beta	Mus musculus	272-280
28386622-16	2017	On the other hand, probucol inhibited carrageenan-induced IL-1beta, TNF-alpha and CXCL1 production as well as NF-kB activation.	Probucol	19-27	interleukin 1 beta	Mus musculus	58-66
28386622-16	2017	On the other hand, probucol inhibited carrageenan-induced IL-1beta, TNF-alpha and CXCL1 production as well as NF-kB activation.	Carrageenan	38-49	interleukin 1 beta	Mus musculus	58-66
28409189-7	2017	Both in vivo and in vitro study showed that daphnetin prevented the production of pro-inflammatory factors including TNF-alpha, IL-1beta, IL-6, NO, and PGE2 after LPS challenge.	daphnetin	44-53	interleukin 1 beta	Mus musculus	128-136
28752965-12	2017	in vitroexperiment, H2O2 increased NALP3 (P&lt;0.05), ASC (P&lt;0.01), caspase-1 (P&lt;0.05) expressions and IL-1beta releasing (P&lt;0.05)and promoted the expressions of collagen-1 and alpha-SMA in both gene and protein levels (P&lt;0.05) in NIH-3T3.	Hydrogen Peroxide	20-24	interleukin 1 beta	Mus musculus	109-117
28138970-6	2017	They also showed a higher inducibility of IL-1beta when treated by pioglitazone.	Pioglitazone	67-79	interleukin 1 beta	Mus musculus	42-50
28559290-7	2017	Treatment of adipocytes with metformin decreased the effects of lipopolysaccharide on inducing the phosphorylation states of JNK p46 and on increasing the mRNA levels of IL-1beta and TNFalpha.	Metformin	29-38	interleukin 1 beta	Mus musculus	170-178
28193826-8	2017	Furthermore, administration of the IL-1beta receptor antagonist, anakinra, efficiently decreased nitric oxide production and vascular proliferation and restored peritoneal function in mouse models of peritonitis, even in mice treated with standard-of-care antibiotherapy.	Nitric Oxide	97-109	interleukin 1 beta	Mus musculus	35-43
27167130-8	2017	ANT showed a protective effect on the increase in the pro-inflammatory cytokines content, especially Interleukin (IL)-1beta, tumoral necrosis factor-alpha and on the reduction of IL-10 induced by LPS.	Anthocyanins	0-3	interleukin 1 beta	Mus musculus	101-123
28545670-5	2017	STUDY DESIGN: Based on the antiviral activity of the five flavonoids, recently reported by our group, the expression of antiviral factors such as IFN-alpha, IFN-lambda, TNF-alpha, IL-1beta, IL-6, Mx, ZAP, OAS, and iNOS was investigated in RAW 264.7 cells pre-treated with these flavonoids.	Flavonoids	58-68	interleukin 1 beta	Mus musculus	180-188
28840690-5	2017	NAC could inhibit PPL-induced ROS excessive production and significantly reduce the release of IL-1beta.	Acetylcysteine	0-3	interleukin 1 beta	Mus musculus	95-103
28840690-8	2017	That is, PPL could lead to inflammatory cascade reaction by promoting the maturation and secretion of IL-1beta through ROS-TXNIP-NLRP3-IL-1beta signaling pathway.	ros	119-122	interleukin 1 beta	Mus musculus	102-110
28410218-7	2017	Our results revealed that 6-Shogaol inhibited LPS-induced TNF-alpha, IL-1beta, IL-6, and PGE2 production in a concentration dependent manner.	shogaol	26-35	interleukin 1 beta	Mus musculus	69-77
28903389-6	2017	Moreover, ISO abated zymosan-augmented lactate dehydrogenase activity, TNF-alpha and IL-1beta production, and apoptosis in WT AECs-II but not in HO-1- or STAT3-silenced cells.	Zymosan	21-28	interleukin 1 beta	Mus musculus	85-93
28644409-4	2017	Quercetin markedly reduced the production of inflammatory mediators (monocyte chemoattractant protein (MCP)-1, interleukin (IL-6), IL-1beta, nitric oxide) by microglia stimulated with saturated fatty acid palmitate and/or lipid-laden microglia-conditioned medium.	Quercetin	0-9	interleukin 1 beta	Mus musculus	131-139
28644409-4	2017	Quercetin markedly reduced the production of inflammatory mediators (monocyte chemoattractant protein (MCP)-1, interleukin (IL-6), IL-1beta, nitric oxide) by microglia stimulated with saturated fatty acid palmitate and/or lipid-laden microglia-conditioned medium.	saturated fatty acid palmitate	184-214	interleukin 1 beta	Mus musculus	131-139
28377486-1	2017	BACKGROUND: Extracellular adenosine triphosphate (ATP) binds as a danger signal to purinergic receptor P2X7 and promotes inflammasome assembly and interleukin-1beta expression.	Adenosine Triphosphate	26-48	interleukin 1 beta	Mus musculus	147-164
28638152-8	2017	HSHF exacerbated these effects, increasing IR, lipolysis, mRNA expression of F4/80 and leptin in AT, Tlr-4 in soleus muscle and IL-6, IL-1beta, VCAM-1, and ICAM-1 protein in AT.	hshf	0-4	interleukin 1 beta	Mus musculus	134-142
28637493-6	2017	The correlation between 5-FU treatment and the expression and activation of NLRP3 inflammasome was further examined by evaluating NLRP3 and IL-1beta expression in OSCC cell lines without or with NLRP3 knocked down.	Fluorouracil	24-28	interleukin 1 beta	Mus musculus	140-148
28637493-15	2017	Further investigation showed that intracellular ROS induced by 5-FU promoted the expression and activation of NLRP3 inflammasome and increased the production of interleukin (IL)-1beta, which then mediated the chemoresistance.	Reactive Oxygen Species	48-51	interleukin 1 beta	Mus musculus	161-183
28637493-15	2017	Further investigation showed that intracellular ROS induced by 5-FU promoted the expression and activation of NLRP3 inflammasome and increased the production of interleukin (IL)-1beta, which then mediated the chemoresistance.	Fluorouracil	63-67	interleukin 1 beta	Mus musculus	161-183
28637493-18	2017	CONCLUSIONS: Our findings suggest that NLRP3 inflammasome promoted 5-FU resistance of OSCC both in vitro and in vivo, and targeting the ROS/NLRP3 inflammasome/IL-1beta signaling pathway may help 5-FU-based adjuvant chemotherapy of OSCC.	Fluorouracil	67-71	interleukin 1 beta	Mus musculus	159-167
28637493-18	2017	CONCLUSIONS: Our findings suggest that NLRP3 inflammasome promoted 5-FU resistance of OSCC both in vitro and in vivo, and targeting the ROS/NLRP3 inflammasome/IL-1beta signaling pathway may help 5-FU-based adjuvant chemotherapy of OSCC.	Reactive Oxygen Species	136-139	interleukin 1 beta	Mus musculus	159-167
28377486-1	2017	BACKGROUND: Extracellular adenosine triphosphate (ATP) binds as a danger signal to purinergic receptor P2X7 and promotes inflammasome assembly and interleukin-1beta expression.	Adenosine Triphosphate	50-53	interleukin 1 beta	Mus musculus	147-164
28637493-18	2017	CONCLUSIONS: Our findings suggest that NLRP3 inflammasome promoted 5-FU resistance of OSCC both in vitro and in vivo, and targeting the ROS/NLRP3 inflammasome/IL-1beta signaling pathway may help 5-FU-based adjuvant chemotherapy of OSCC.	Fluorouracil	195-199	interleukin 1 beta	Mus musculus	159-167
28377486-8	2017	However, priming with lipopolysaccharide, followed by stimulation with ATP, led to an activation of caspase 1 and interleukin-1beta in P2X7-competent macrophages.	Adenosine Triphosphate	71-74	interleukin 1 beta	Mus musculus	114-131
28465482-10	2017	The results showed that ADH treatment improved liver histology and decreased the levels of ALT, AST, MPO, IL-1beta, TNF-alpha, as well as MDA and ROS levels of hepatic tissues in a dose-dependent manner.	andrographolide	24-27	interleukin 1 beta	Mus musculus	106-114
28499868-8	2017	Besides, PM2.5 activated NFkappaB pathway and increased gene expression of IL-1beta and IL-6 in NMVMs with hypoxia, which could be effectively reversed by SN-50-induced blockade of NFkappaB translocation to the nucleus.	SN-50	155-160	interleukin 1 beta	Mus musculus	75-83
28634361-6	2017	The levels of proinflammatory cytokines IL-6, IL-1beta and TNF in serum as well as mRNA expression in colon were significantly reduced in the uridine treated groups.	Uridine	142-149	interleukin 1 beta	Mus musculus	46-54
28623945-2	2017	miRNA-155 (miR-155) plays a role in pulmonary fibrosis and its expression can be induced with interleukin (IL)-1beta.	mirna-155	0-9	interleukin 1 beta	Mus musculus	94-116
28977826-5	2017	In addition, the levels of TGF-beta, IL-6, TNF-alpha and IL-1beta in the tissues dramatically reduced in the irradiated mice pretreated with Ilomastat.	ilomastat	141-150	interleukin 1 beta	Mus musculus	57-65
28623945-2	2017	miRNA-155 (miR-155) plays a role in pulmonary fibrosis and its expression can be induced with interleukin (IL)-1beta.	mir-155	11-18	interleukin 1 beta	Mus musculus	94-116
28617316-5	2017	Interestingly, pretreatment with 3-methyl adenine, a pharmacological inhibitor of autophagy, abrogated the suppressive effects of gAcrp on IL-1beta secretion and caspase-1 activation, indicating the crucial role of autophagy induction in gAcrp-modulation of the inflammasome activation.	3-methyladenine	33-49	interleukin 1 beta	Mus musculus	139-147
28617316-5	2017	Interestingly, pretreatment with 3-methyl adenine, a pharmacological inhibitor of autophagy, abrogated the suppressive effects of gAcrp on IL-1beta secretion and caspase-1 activation, indicating the crucial role of autophagy induction in gAcrp-modulation of the inflammasome activation.	gacrp	130-135	interleukin 1 beta	Mus musculus	139-147
28670276-5	2017	In addition, UA also reversed gamma irradiation induced inflammatory responses, as indicated by the decreased production of TNF-alpha, IL-6, and IL-1beta.	ursolic acid	13-15	interleukin 1 beta	Mus musculus	145-153
28594906-4	2017	Braylin (10-40 muM) reduced the production of nitrite, IL-1beta, TNF-alpha and IL-6 by J774 cells or peritoneal exudate macrophages stimulated with LPS and IFN-gamma.	Braylin	0-7	interleukin 1 beta	Mus musculus	55-63
28594379-4	2017	The results demonstrated that alisol F and 25-anhydroalisol F could suppress LPS-induced production of nitric oxide (NO), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and interleukin-1beta (IL-1beta), as well as inhibit the mRNA and protein levels of inducible nitric oxide (iNOS) and cyclooxygenase-2 (COX-2).	alisol F	30-38	interleukin 1 beta	Mus musculus	189-206
28594379-4	2017	The results demonstrated that alisol F and 25-anhydroalisol F could suppress LPS-induced production of nitric oxide (NO), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and interleukin-1beta (IL-1beta), as well as inhibit the mRNA and protein levels of inducible nitric oxide (iNOS) and cyclooxygenase-2 (COX-2).	alisol F	30-38	interleukin 1 beta	Mus musculus	208-216
28465253-3	2017	MATERIALS AND METHODS: Anti-inflammatory activity of CMEP-NQ was investigated in LPS-treated RAW264.7 cells by measuring the levels of NO, PGE2, and cytokines (IL1beta, IL-6, TNF-alpha) in the culture supernatants and the TLR4-mediated intracellular events including association of MyD88 with IRAK1, activation of IRAK1, TAK1, MAPKs, NF-kappaB/AP-1, and IRF3, and generation of ROS.	2-carbomethoxy-2,3-epoxy-3-prenyl-1,4-naphthoquinone	53-60	interleukin 1 beta	Mus musculus	160-167
28587280-7	2017	Results: l-CDL significantly attenuated TCIP hypersensitivity, accompanying with downregulation of TNF-alpha and IL-1beta expression levels and declined astrocytes and microglial activation.	l-cdl	9-14	interleukin 1 beta	Mus musculus	113-121
28594379-4	2017	The results demonstrated that alisol F and 25-anhydroalisol F could suppress LPS-induced production of nitric oxide (NO), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and interleukin-1beta (IL-1beta), as well as inhibit the mRNA and protein levels of inducible nitric oxide (iNOS) and cyclooxygenase-2 (COX-2).	25-Anhydroalisol F	43-61	interleukin 1 beta	Mus musculus	189-206
28594379-4	2017	The results demonstrated that alisol F and 25-anhydroalisol F could suppress LPS-induced production of nitric oxide (NO), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and interleukin-1beta (IL-1beta), as well as inhibit the mRNA and protein levels of inducible nitric oxide (iNOS) and cyclooxygenase-2 (COX-2).	25-Anhydroalisol F	43-61	interleukin 1 beta	Mus musculus	208-216
28499273-2	2017	It has been also shown that palmitic acid (PA) activates NLRP3 inflammasome and promotes interleukin-1beta (IL-1beta) secretion in Kupffer cells (KCs).	Palmitic Acid	28-41	interleukin 1 beta	Mus musculus	89-106
28499273-2	2017	It has been also shown that palmitic acid (PA) activates NLRP3 inflammasome and promotes interleukin-1beta (IL-1beta) secretion in Kupffer cells (KCs).	Palmitic Acid	28-41	interleukin 1 beta	Mus musculus	108-116
28499273-2	2017	It has been also shown that palmitic acid (PA) activates NLRP3 inflammasome and promotes interleukin-1beta (IL-1beta) secretion in Kupffer cells (KCs).	Palmitic Acid	43-45	interleukin 1 beta	Mus musculus	89-106
28499273-2	2017	It has been also shown that palmitic acid (PA) activates NLRP3 inflammasome and promotes interleukin-1beta (IL-1beta) secretion in Kupffer cells (KCs).	Palmitic Acid	43-45	interleukin 1 beta	Mus musculus	108-116
28587280-9	2017	Further, l-CDL could suppress TNF-alpha-induced astrocytes activation and IL-1beta expression through downregulating the CCL2/CCR2.	l-cdl	9-14	interleukin 1 beta	Mus musculus	74-82
28342364-9	2017	The reduced severity of the disease in animals treated with quercetin was associated with decreased levels of TNF-alpha, IL-1beta, IL-17, and MCP-1.	Quercetin	60-69	interleukin 1 beta	Mus musculus	121-129
28977876-0	2017	Wogonoside inhibits IL-1beta induced catabolism and hypertrophy in mouse chondrocyte and ameliorates murine osteoarthritis.	wogonoside	0-10	interleukin 1 beta	Mus musculus	20-28
28977876-6	2017	Wogonoside also inhibited hypertrophy and the generation of vascular endothelial growth factor (VEGF) in interleukin-1beta (IL-1beta)-induced chondrocytes.	wogonoside	0-10	interleukin 1 beta	Mus musculus	105-122
28977876-6	2017	Wogonoside also inhibited hypertrophy and the generation of vascular endothelial growth factor (VEGF) in interleukin-1beta (IL-1beta)-induced chondrocytes.	wogonoside	0-10	interleukin 1 beta	Mus musculus	124-132
28977876-10	2017	In conclusion, our stduy demonstrates that wogonoside attenuates IL-1beta-induced ECM degradation and hypertrophy in mouse chondrocytes via suppressing the activation of NF-kappaB/HIF-2alpha by the PI3K/AKT pathway.	wogonoside	43-53	interleukin 1 beta	Mus musculus	65-73
28243801-5	2017	Ribavirin significantly suppressed toll-like receptor 2 and 4 expression in the lung and decreased the level of IL-1beta, IL-6, TNF-alpha, and IFN-gamma in lung tissues of mice infected with influenza virus.	Ribavirin	0-9	interleukin 1 beta	Mus musculus	112-120
28193789-6	2017	EPA treatment also reduced islet interleukin-1beta expression, a proinflammatory cytokine known to stimulate prostaglandin production and EP3 expression.	Eicosapentaenoic Acid	0-3	interleukin 1 beta	Mus musculus	33-50
28380410-4	2017	Quercetin administration not only showed predominance of Th2 immune response by increasing the IgG1 antibody titres, but also increased the infiltration of CD11c+ dendritic cells in the mouse peritoneum and also increased LPS activated IL-1beta and nitric oxide (NO) production by peritoneal macrophages.	Quercetin	0-9	interleukin 1 beta	Mus musculus	236-244
28306139-10	2017	In addition, AS-1 decreased ROS, inflammasome activation and IL-1beta production in free fatty acid-LPS-treated Kupffer cells.	Fatty Acids, Nonesterified	84-99	interleukin 1 beta	Mus musculus	61-69
28193789-6	2017	EPA treatment also reduced islet interleukin-1beta expression, a proinflammatory cytokine known to stimulate prostaglandin production and EP3 expression.	Prostaglandins	109-122	interleukin 1 beta	Mus musculus	33-50
28587416-8	2017	Berberine also significantly inhibited the expression of interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha mRNA and phosphorylation of signal transducer and activator of transcription 3.	Berberine	0-9	interleukin 1 beta	Mus musculus	57-79
28027595-4	2017	We found that either genetically or pharmacologically inhibiting the SREBP pathway dramatically reduced diethylnitrosamine-induced HCC progression by down-regulating tumor-promoting cytokines, including interleukin (IL)-6, tumor necrosis factor alpha, and IL-1beta.	Diethylnitrosamine	104-122	interleukin 1 beta	Mus musculus	256-264
28303415-6	2017	In addition, the inhibition of Sch B on TNF-alpha, IL-6, IL-1beta, and PGE2 production were reversed by PPAR-gamma antagonist GW9662.	2-chloro-5-nitrobenzanilide	126-132	interleukin 1 beta	Mus musculus	57-65
28155010-9	2017	Finally, pretreatment with p38 inhibitor, SB203580, attenuated the pIONL-induced mechanical allodynia and decreased the mRNA expression of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in the TG.	SB 203580	42-50	interleukin 1 beta	Mus musculus	220-237
28155010-9	2017	Finally, pretreatment with p38 inhibitor, SB203580, attenuated the pIONL-induced mechanical allodynia and decreased the mRNA expression of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in the TG.	SB 203580	42-50	interleukin 1 beta	Mus musculus	239-247
28315999-10	2017	Furthermore, artesunate significantly inhibited the levels of TNF-alpha, IL-1beta, and IL-6.	Artesunate	13-23	interleukin 1 beta	Mus musculus	73-81
28161732-5	2017	Results showed picroside II significantly decreased the concentrations of TNF-alpha, IL-1beta, and IL-6 in cells and mice.	picroside II	15-27	interleukin 1 beta	Mus musculus	85-93
28289752-4	2017	Our results showed that moringin + alpha-CD inhibits the production of inflammatory mediators in LPS-stimulated macrophages by down-regulation of pro-inflammatory cytokines (TNF-alpha and IL-1beta), by preventing IkappaB-alpha phosphorylation, translocation of the nuclear factor-kappaB (NF-kappaB), and also via the suppression of Akt and p38 phosphorylation.	moringin	24-32	interleukin 1 beta	Mus musculus	188-196
28289752-4	2017	Our results showed that moringin + alpha-CD inhibits the production of inflammatory mediators in LPS-stimulated macrophages by down-regulation of pro-inflammatory cytokines (TNF-alpha and IL-1beta), by preventing IkappaB-alpha phosphorylation, translocation of the nuclear factor-kappaB (NF-kappaB), and also via the suppression of Akt and p38 phosphorylation.	alpha-cyclodextrin	35-43	interleukin 1 beta	Mus musculus	188-196
28410530-3	2017	In the present study, we found that treatment with metformin inhibited the cardiac expression of pro-inflammatory cytokines including tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta) and interleukin 6 (IL-6) in endotoxin-challenged mice.	Metformin	51-60	interleukin 1 beta	Mus musculus	175-193
28342021-8	2017	For inflammatory response, these results showed that Arg-Arg can decrease the LPS-induced expression of IL-1beta and the rSEC-induced expression of TNF-alpha; however, it can upregulate the LPS-induced expression of IL-6 and TNF-alpha and the rSEC-induced expression level of IL-1beta.	Arg-arg	53-60	interleukin 1 beta	Mus musculus	104-112
28342021-8	2017	For inflammatory response, these results showed that Arg-Arg can decrease the LPS-induced expression of IL-1beta and the rSEC-induced expression of TNF-alpha; however, it can upregulate the LPS-induced expression of IL-6 and TNF-alpha and the rSEC-induced expression level of IL-1beta.	Arg-arg	53-60	interleukin 1 beta	Mus musculus	276-284
28279768-4	2017	PAP (50, 100mg/kg) significantly inhibited the CCl4-incuded overproduction of inflammatory cytokines including tumor necrosis factor alpha (TNF-alpha), cytokines interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) in serum and liver.	Carbon Tetrachloride	47-51	interleukin 1 beta	Mus musculus	162-179
28279768-4	2017	PAP (50, 100mg/kg) significantly inhibited the CCl4-incuded overproduction of inflammatory cytokines including tumor necrosis factor alpha (TNF-alpha), cytokines interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) in serum and liver.	Carbon Tetrachloride	47-51	interleukin 1 beta	Mus musculus	181-189
28365872-9	2017	In vitro, PA induced MCP-1 and augmented LPS-primed production of IL-1beta and TNF-alpha in macrophages.	Palmitic Acid	10-12	interleukin 1 beta	Mus musculus	66-74
28410530-3	2017	In the present study, we found that treatment with metformin inhibited the cardiac expression of pro-inflammatory cytokines including tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta) and interleukin 6 (IL-6) in endotoxin-challenged mice.	Metformin	51-60	interleukin 1 beta	Mus musculus	195-203
28820392-7	2017	Furthermore, Ile-Pro-Pro was mildly pro-inflammatory as exhibited by increased pro-inflammatory cytokine interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) levels in colon.	isoleucyl-prolyl-proline	13-24	interleukin 1 beta	Mus musculus	105-122
28096454-5	2017	CCCP, an uncoupler and antimycin A, an inhibitor of the mitochondrial electron transport chain, inhibited IL-1beta release induced by ATP but not by other stimuli.	Carbonyl Cyanide m-Chlorophenyl Hydrazone	0-4	interleukin 1 beta	Mus musculus	106-114
28096454-5	2017	CCCP, an uncoupler and antimycin A, an inhibitor of the mitochondrial electron transport chain, inhibited IL-1beta release induced by ATP but not by other stimuli.	Antimycin A	23-34	interleukin 1 beta	Mus musculus	106-114
28096454-5	2017	CCCP, an uncoupler and antimycin A, an inhibitor of the mitochondrial electron transport chain, inhibited IL-1beta release induced by ATP but not by other stimuli.	Adenosine Triphosphate	134-137	interleukin 1 beta	Mus musculus	106-114
28165872-6	2017	Inhibition of NAMPT by the intracellular NAMPT (iNAMPT) inhibitor, FK866, or by the sirtuin inhibitor, nicotinamide, in PDL cells led to inhibition of the IL1beta or Ad- Nampt-induced upregulation of catabolic factors, whereas treatment with recombinant NAMPT protein or blockade of extracellular NAMPT (eNAMPT) with blocking antibody did not.	N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide	67-72	interleukin 1 beta	Mus musculus	155-162
28165872-6	2017	Inhibition of NAMPT by the intracellular NAMPT (iNAMPT) inhibitor, FK866, or by the sirtuin inhibitor, nicotinamide, in PDL cells led to inhibition of the IL1beta or Ad- Nampt-induced upregulation of catabolic factors, whereas treatment with recombinant NAMPT protein or blockade of extracellular NAMPT (eNAMPT) with blocking antibody did not.	Niacinamide	103-115	interleukin 1 beta	Mus musculus	155-162
28404641-5	2017	Both DHA metabolites inhibited Hcys-induced caspase-1 activation and interleukin-1beta production.	dehydroacetic acid	5-8	interleukin 1 beta	Mus musculus	69-86
28820392-7	2017	Furthermore, Ile-Pro-Pro was mildly pro-inflammatory as exhibited by increased pro-inflammatory cytokine interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) levels in colon.	isoleucyl-prolyl-proline	13-24	interleukin 1 beta	Mus musculus	124-132
27909971-4	2017	Further studies demonstrated that gastrodin decreased the levels of the pro-inflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha while increasing interleukin-10, an anti-inflammatory cytokine in the brain.	gastrodin	34-43	interleukin 1 beta	Mus musculus	99-148
28389348-8	2017	The result also indicated that the resveratrol can decrease the expression of pro-inflammatory cytokines TNF-alpha and IL-1beta.	Resveratrol	35-46	interleukin 1 beta	Mus musculus	119-127
28330776-10	2017	The topical application of GA inhibited the genes expression of IL-1beta, IL-6, IL-8, COX-2, and MCP-1 in UVB-exposed mouse skin.	glycolic acid	27-29	interleukin 1 beta	Mus musculus	64-72
28615091-5	2017	Results In the early stage, TAMs expressed high levels of M1-related genes, such as IL-1beta, CD80, CD86.	tams	28-32	interleukin 1 beta	Mus musculus	84-92
28258409-10	2017	Pentoxifylline significantly reduced the expression of TNFalpha and IL-1beta, but not NF-kappaB.	Pentoxifylline	0-14	interleukin 1 beta	Mus musculus	68-76
28615097-8	2017	Results Quercetin significantly reduced the pathological changes of lung tissues, lowered PaCO2 while increased PaO2 and D/W ratio, down-regulated the expressions of iNOS, TNF-alpha, IL-1beta while up-regulated the expressions of IL-4 and IL-10 in SW-ALI mice.	Quercetin	8-17	interleukin 1 beta	Mus musculus	183-191
28539281-8	2017	The mice pretreated with LPS expressed obviously increased levels of IBA-1 protein, TNF-alpha, and IL-1beta in the hippocampus (P&lt;0.01), and choline pretreatment significantly lowered the expressions of IBA-1 protein and IL-1beta (P&lt;0.05).	Choline	144-151	interleukin 1 beta	Mus musculus	224-232
28603496-8	2017	Mechanistic studies indicated that AC exerted its anti-inflammatory activity by inhibiting the mRNA expression levels of inducible nitric oxide synthase, cyclooxygenase-2, TNF-alpha, interleukin (IL)-1beta, and IL-6 and by suppressing the production of inflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 in LPS-treated RAW 264.7 cells.	anhuienoside C	35-37	interleukin 1 beta	Mus musculus	183-205
28603496-8	2017	Mechanistic studies indicated that AC exerted its anti-inflammatory activity by inhibiting the mRNA expression levels of inducible nitric oxide synthase, cyclooxygenase-2, TNF-alpha, interleukin (IL)-1beta, and IL-6 and by suppressing the production of inflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 in LPS-treated RAW 264.7 cells.	anhuienoside C	35-37	interleukin 1 beta	Mus musculus	295-303
28400288-6	2017	The anti-inflammatory activity of EAFOg and its ability to acts on leucocytes infiltration, inflammatory mediators as NO, IL-1beta, TNF-alpha, and IL-10 in lipopolysaccharide-induced peritonitis in mice and LPS-stimulated RAW 264.7 macrophage were evaluated.	eafog	34-39	interleukin 1 beta	Mus musculus	122-130
28400288-12	2017	Also, EAFOg (5, 20 and 100microg/mL) produced significant reduction in NO, IL-1beta, and TNF-alpha in RAW 264.7 cells.	eafog	6-11	interleukin 1 beta	Mus musculus	75-83
28400288-14	2017	CONCLUSION: The flavonoid-rich fraction of O. gratissimum leaves demonstrated anti-inflammatory activity via mechanisms that involves inhibition of leucocytes influx, NO, IL-1beta, and TNF-alpha in vivo and in vitro, thus supporting its therapeutic potential in slowing down inflammatory processes in chronic diseases.	Flavonoids	16-25	interleukin 1 beta	Mus musculus	171-179
28508104-5	2017	Quercetin inhibited MSU-induced mechanical hyperalgesia, leukocyte recruitment, TNFalpha and IL-1beta production, superoxide anion production, inflammasome activation, decrease of antioxidants levels, NFkappaB activation, and inflammasome components mRNA expression.	Quercetin	0-9	interleukin 1 beta	Mus musculus	93-101
28524081-9	2017	These results suggest that the hepatoprotective effects of TA may be related to its anti-inflammatory effect by decreasing thiobarbituric acid reactive substances (TBARS), iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6, and inhibiting NF-kappaB and MAPK activation.	euscaphic acid	59-61	interleukin 1 beta	Mus musculus	196-204
28524081-6	2017	Additionally, TA attenuated the APAP-induced production of nitric oxide (NO), reactive oxygen species (ROS), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6.	Acetaminophen	32-36	interleukin 1 beta	Mus musculus	150-167
28524081-6	2017	Additionally, TA attenuated the APAP-induced production of nitric oxide (NO), reactive oxygen species (ROS), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6.	Acetaminophen	32-36	interleukin 1 beta	Mus musculus	169-177
28508104-5	2017	Quercetin inhibited MSU-induced mechanical hyperalgesia, leukocyte recruitment, TNFalpha and IL-1beta production, superoxide anion production, inflammasome activation, decrease of antioxidants levels, NFkappaB activation, and inflammasome components mRNA expression.	msu	20-23	interleukin 1 beta	Mus musculus	93-101
28656058-9	2017	Application of Mel or 8MP in cuff-implanted models inhibited the activation of peptidergic neurons and neuro-inflammation in the DRGs by down-regulating c-fos, calcitonin gene-related peptide [CGRP], and tumor necrosis factor-1alpha [TNF-1alpha] and interleukin-1beta [IL-1beta].	Melatonin	15-18	interleukin 1 beta	Mus musculus	250-267
28656058-9	2017	Application of Mel or 8MP in cuff-implanted models inhibited the activation of peptidergic neurons and neuro-inflammation in the DRGs by down-regulating c-fos, calcitonin gene-related peptide [CGRP], and tumor necrosis factor-1alpha [TNF-1alpha] and interleukin-1beta [IL-1beta].	Melatonin	15-18	interleukin 1 beta	Mus musculus	269-277
28656058-9	2017	Application of Mel or 8MP in cuff-implanted models inhibited the activation of peptidergic neurons and neuro-inflammation in the DRGs by down-regulating c-fos, calcitonin gene-related peptide [CGRP], and tumor necrosis factor-1alpha [TNF-1alpha] and interleukin-1beta [IL-1beta].	8-methoxy-2-propionamidotetralin	22-25	interleukin 1 beta	Mus musculus	250-267
28493895-8	2017	In vitro experiments revealed that ouabain induced NLRP3 inflammasome activation as well as subsequent IL-1beta release from macrophages, and this activation was mediated by K+ efflux.	Ouabain	35-42	interleukin 1 beta	Mus musculus	103-111
28656058-9	2017	Application of Mel or 8MP in cuff-implanted models inhibited the activation of peptidergic neurons and neuro-inflammation in the DRGs by down-regulating c-fos, calcitonin gene-related peptide [CGRP], and tumor necrosis factor-1alpha [TNF-1alpha] and interleukin-1beta [IL-1beta].	8-methoxy-2-propionamidotetralin	22-25	interleukin 1 beta	Mus musculus	269-277
28214532-5	2017	Furthermore, depletion of endogenous SMN by RNA interference enhanced the IL-1beta-induced activation of IKK and production of inflammatory mediators such as TNF-alpha and nitric oxide in BV2 cells.	(S)-(+)-Mandelic acid	37-40	interleukin 1 beta	Mus musculus	74-82
28415686-4	2017	CS could significantly inhibited HFD-induced lipid homeostasis, and inhibited inflammation in adipose tissue, as reflected by the decreased mRNA expression levels of inflammation-related genes and secretion of the chemokines/cytokines, inhibited the accumulation of adipose tissue macrophages (ATMs) and shifted their polarization from M1 to M2, suppressed HFD-induced expression of NLRP3 inflammasome component genes and decreased IL-1beta and Caspase-1 production in mice.	chikusetsu saponin IVa	0-2	interleukin 1 beta	Mus musculus	432-440
28482922-10	2017	The rSj-Cys conferred therapeutic efficacy was associated with upregualted IL-10 and TGF-beta1 cytokines and reduced pro-inflammatory cytokines TNF-alpha, IL-6, IL-1beta.	rsj-cys	4-11	interleukin 1 beta	Mus musculus	161-169
28481246-8	2017	Moreover, CMP in combination with 5-FU alleviated severe liver injury induced by 5-FU via reducing the levels of ROS, IL-1beta, and IL-6, decreasing expression of p-IkappaB-alpha, NF-kappaB, p-NF-kappaB, pp38 and Bax, and elevating levels of Nrf2, GCL, HO-1 and Bcl-2.	Fluorouracil	34-38	interleukin 1 beta	Mus musculus	118-126
28427172-3	2017	Next, we measured the effect of crizotinib on the cartilage degeneration induced by interleukin-1beta in chondrocytes.	Crizotinib	32-42	interleukin 1 beta	Mus musculus	84-101
28427172-4	2017	Crizotinib ameliorated the pathological changes induced by interleukin-1beta via its anti-angiogenesis function.	Crizotinib	0-10	interleukin 1 beta	Mus musculus	59-76
28482444-10	2017	After stimulated by Pg LPS, mRNA and protein expression of IL-1beta (P&lt;0.01, P&lt;0.01) and NALP3 (P&lt;0.01, P&lt;0.01) significantly increased; but the expression of IL-1beta (P=0.002, P=0.027) and NALP3 (P&lt;0.01, P&lt;0.01) were decreased when pretreated with AC-YVAD-CMK.	ac-yvad	268-275	interleukin 1 beta	Mus musculus	59-67
28216619-7	2017	15d-PGJ2 pretreatment significantly decreased the serum TNF-alpha and IL-1beta levels and the hepatic expression of F4/80, a major biomarker of macrophages.	15-deoxy-delta(12,14)-prostaglandin J2	0-8	interleukin 1 beta	Mus musculus	70-78
28273337-1	2017	BACKGROUND: Ethanol (EtOH) consumption leads to an increase of proinflammatory signaling via activation of Toll-like receptors (TLRs) such as TLR3 and TLR4 that leads to kinase activation (ERK1/2, p38, TBK1), transcription factor activation (NFkappaB, IRF3), and increased transcription of proinflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6.	Ethanol	12-19	interleukin 1 beta	Mus musculus	335-343
28273337-1	2017	BACKGROUND: Ethanol (EtOH) consumption leads to an increase of proinflammatory signaling via activation of Toll-like receptors (TLRs) such as TLR3 and TLR4 that leads to kinase activation (ERK1/2, p38, TBK1), transcription factor activation (NFkappaB, IRF3), and increased transcription of proinflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6.	Ethanol	21-25	interleukin 1 beta	Mus musculus	335-343
28273337-6	2017	LPS, Poly(I:C), and EtOH all increased TNF-alpha and IL-1beta mRNA, and EtOH further increased TLR2, 7, 8, and MD-2 mRNA in BV2.	poly	5-9	interleukin 1 beta	Mus musculus	53-61
28273337-6	2017	LPS, Poly(I:C), and EtOH all increased TNF-alpha and IL-1beta mRNA, and EtOH further increased TLR2, 7, 8, and MD-2 mRNA in BV2.	Ethanol	20-24	interleukin 1 beta	Mus musculus	53-61
28214532-5	2017	Furthermore, depletion of endogenous SMN by RNA interference enhanced the IL-1beta-induced activation of IKK and production of inflammatory mediators such as TNF-alpha and nitric oxide in BV2 cells.	Nitric Oxide	172-184	interleukin 1 beta	Mus musculus	74-82
26549801-0	2017	Magnesium ion influx reduces neuroinflammation in Abeta precursor protein/Presenilin 1 transgenic mice by suppressing the expression of interleukin-1beta.	Magnesium	0-9	interleukin 1 beta	Mus musculus	136-153
28282788-3	2017	In the present study, we showed that berberine (BBR) significantly suppressed saturated fatty acid palmitate (PA)-induced NLRP3 inflammasome activation and interleukin-1beta (IL-1beta) release in macrophages, which was one of the most important mediators in the insulin sensitivity of adipose tissue.	Berberine	37-46	interleukin 1 beta	Mus musculus	156-173
28282788-3	2017	In the present study, we showed that berberine (BBR) significantly suppressed saturated fatty acid palmitate (PA)-induced NLRP3 inflammasome activation and interleukin-1beta (IL-1beta) release in macrophages, which was one of the most important mediators in the insulin sensitivity of adipose tissue.	Berberine	37-46	interleukin 1 beta	Mus musculus	175-183
28282788-3	2017	In the present study, we showed that berberine (BBR) significantly suppressed saturated fatty acid palmitate (PA)-induced NLRP3 inflammasome activation and interleukin-1beta (IL-1beta) release in macrophages, which was one of the most important mediators in the insulin sensitivity of adipose tissue.	Berberine	48-51	interleukin 1 beta	Mus musculus	156-173
28282788-3	2017	In the present study, we showed that berberine (BBR) significantly suppressed saturated fatty acid palmitate (PA)-induced NLRP3 inflammasome activation and interleukin-1beta (IL-1beta) release in macrophages, which was one of the most important mediators in the insulin sensitivity of adipose tissue.	Berberine	48-51	interleukin 1 beta	Mus musculus	175-183
28469735-9	2017	Concentrations of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the media were increased by exposure to both kaolins, but in the case of kaolin-P, these inflammatory cytokines were significantly elevated.	kaolin-p	167-175	interleukin 1 beta	Mus musculus	18-35
28558868-5	2017	Moreover, vaticaffinol markedly down-regulated renal protein levels of NOD-like receptor 3 (NLRP3), apoptosis-associated speck-like (ASC), and Caspase-1, resulting in the reduction of interleukin (IL)-1beta, IL-18, IL-6 and tumor necrosis factor-alpha (TNF-alpha) levels in this animal model.	vaticaffinol	10-22	interleukin 1 beta	Mus musculus	184-206
28224201-11	2017	DEX suppressed the infiltration of macrophages and T cells into the kidneys following cisplatin treatment, which was involved in the inhibition of NF-kappaB activation and decreased expression of TNF-alpha, IL-1beta, IL-6, and MCP-1.	Dexmedetomidine	0-3	interleukin 1 beta	Mus musculus	207-215
28350048-4	2017	The production of cytokines, such as interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in bronchoalveolar fluid and serum was also decreased following treatment with silybin.	Silybin	189-196	interleukin 1 beta	Mus musculus	37-54
28249220-7	2017	In addition, the inflammatory responses induced by paraquat were inhibited after treatment with chloroquine, as indicated by the decreased number of leukocytes, the reduced levels of TNF-alpha, IL-1beta and IL-6 in the bronchoalveolar lavage fluid, the reduced NO content, and downregulation of iNOS expression in lung tissues.	Paraquat	51-59	interleukin 1 beta	Mus musculus	194-202
28249220-7	2017	In addition, the inflammatory responses induced by paraquat were inhibited after treatment with chloroquine, as indicated by the decreased number of leukocytes, the reduced levels of TNF-alpha, IL-1beta and IL-6 in the bronchoalveolar lavage fluid, the reduced NO content, and downregulation of iNOS expression in lung tissues.	Chloroquine	96-107	interleukin 1 beta	Mus musculus	194-202
28284148-8	2017	Furthermore, UA effectively moderated the histopathological changes, reduced the content of MDA, HYP, TNF-alpha, IL-1beta, IL-6 and TGF-beta1, and increased the level of SOD when combined with BLM in lung tissues of H22-bearing mice, which was believed to be related to the inhibition on the protein level of p-Smad2/3 and enhancement of Smad7 expression.	usnic acid	13-15	interleukin 1 beta	Mus musculus	113-121
28350048-4	2017	The production of cytokines, such as interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in bronchoalveolar fluid and serum was also decreased following treatment with silybin.	Silybin	189-196	interleukin 1 beta	Mus musculus	56-64
27463229-8	2017	They activated Nrf2 transcription factor, abolished IL-1beta-induced NO, PGE2 , MMP-13, and HNE production as well as IL-beta-induced GSTA4-4 down-regulation.	Dinoprostone	73-77	interleukin 1 beta	Mus musculus	52-60
28167322-7	2017	In vitro, cholesterol crystals activated Kupffer cells and macrophages to release IL-1beta; MCC950 abolished this, and the associated neutrophil migration.	Cholesterol	10-21	interleukin 1 beta	Mus musculus	82-90
28298525-4	2017	We have found that in murine bone marrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcription, as well as boosting the ability of LPS to induce IL-1beta mRNA and pro-IL-1beta while inhibiting the production of TNF-alpha.	Dinoprostone	62-66	interleukin 1 beta	Mus musculus	126-134
28368517-12	2017	2-DG administration also significantly improved survival outcome, reduced kidney and liver injury, attenuated sepsis-increased serum levels of tumor necrosis factor alpha and interleukin 1beta as well as lactate, and enhanced the expression of Sirt1 and Sirt3 in the myocardium, which play an important role in mitochondrial function and metabolism.	Deoxyglucose	0-4	interleukin 1 beta	Mus musculus	175-192
28298525-4	2017	We have found that in murine bone marrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcription, as well as boosting the ability of LPS to induce IL-1beta mRNA and pro-IL-1beta while inhibiting the production of TNF-alpha.	Dinoprostone	62-66	interleukin 1 beta	Mus musculus	199-207
28298525-4	2017	We have found that in murine bone marrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcription, as well as boosting the ability of LPS to induce IL-1beta mRNA and pro-IL-1beta while inhibiting the production of TNF-alpha.	Cyclic AMP	75-79	interleukin 1 beta	Mus musculus	126-134
28298525-4	2017	We have found that in murine bone marrow-derived macrophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcription, as well as boosting the ability of LPS to induce IL-1beta mRNA and pro-IL-1beta while inhibiting the production of TNF-alpha.	Cyclic AMP	75-79	interleukin 1 beta	Mus musculus	199-207
27706903-7	2017	Importantly, the combination of N-acetylcysteine and tauroursodeoxycholic acid improved serum transaminase levels, reduced histopathological liver damage, UPR-activated CHOP, oxidative stress, caspase 1 expression, NLRP3 levels, IL-1beta levels and the expression of pro-inflammatory cytokines and this to a greater extend than N-acetylcysteine alone.	Acetylcysteine	32-48	interleukin 1 beta	Mus musculus	229-237
28433068-0	2017	The role of interleukin-1beta and extracellular signal-regulated kinase 1/2 in glucose-stimulated insulin secretion.	Glucose	79-86	interleukin 1 beta	Mus musculus	12-29
27706903-7	2017	Importantly, the combination of N-acetylcysteine and tauroursodeoxycholic acid improved serum transaminase levels, reduced histopathological liver damage, UPR-activated CHOP, oxidative stress, caspase 1 expression, NLRP3 levels, IL-1beta levels and the expression of pro-inflammatory cytokines and this to a greater extend than N-acetylcysteine alone.	ursodoxicoltaurine	53-78	interleukin 1 beta	Mus musculus	229-237
28433068-9	2017	After intervention by 0.15 ng/mL, 1.5 ng/mL, and 15 ng/mL IL-1beta, the level of ERK1/2 phosphorylation induced by 1.38mM glucose stimulation decreased in a dose-dependent manner, and the insulin level correspondingly decreased.	Glucose	122-129	interleukin 1 beta	Mus musculus	58-66
27860258-5	2017	Sesamol reduced LPS-induced glial over-activation by inhibiting MAPK and NFkappaB pathway as well as expressions of inflammatory mediators such as IL-1beta and TNFalpha.	sesamol	0-7	interleukin 1 beta	Mus musculus	147-155
28459871-9	2017	On day 1 post-treatment, major upregulations of Ifng, Foxp3, Il1b, Il2, and Il6 genes in colon were only observed in the mice simultaneously treated with ampicillin.	Ampicillin	154-164	interleukin 1 beta	Mus musculus	61-65
28208071-8	2017	Additionally, anthocyanin significantly reduced the expression and secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in the calvaria of CoCrMo-stimulated mice.	Anthocyanins	14-25	interleukin 1 beta	Mus musculus	121-138
28208071-8	2017	Additionally, anthocyanin significantly reduced the expression and secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in the calvaria of CoCrMo-stimulated mice.	Anthocyanins	14-25	interleukin 1 beta	Mus musculus	140-148
28247333-5	2017	Our results indicate that treatment with 6-OHDA promotes microglial polarization toward the M1 state in BV2 microglia cells by increasing the release of interleukin (IL)-6, IL-1beta, or tumor necrosis factor-alpha, which can be prevented by pretreatment with DEX.	Oxidopamine	41-47	interleukin 1 beta	Mus musculus	173-181
28487022-5	2017	Specifically, 4X (versus 1X) choline reduced the transcript (P &lt;= 0.05) and protein (P &lt;= 0.06) expression of TNF-a and IL-1beta in the male placentas at E10.5 and E18.5, respectively.	Choline	29-36	interleukin 1 beta	Mus musculus	126-134
28487022-6	2017	In the female placentas, 4X (versus 1X) choline modulated the transcript expression of Il1b in a biphasic pattern with reduced Il1b at E12.5 (P = 0.045) and E18.5 (P = 0.067) but increased Il1b at E15.5 (P = 0.031).	Choline	40-47	interleukin 1 beta	Mus musculus	87-91
27753791-6	2017	Our studies revealed that inhibition of sEH with TPPU attenuated the morphological changes in mice, decreased the neutrophil infiltration to the lung, pro-inflammatory cytokine levels (IL-1beta and TNF-alpha) in serum and bronchoalveolar lavage fluid (BALF), and alveolar capillary leakage (lung wet/dry ratio and total protein concentration in BALF).	TPPU	49-53	interleukin 1 beta	Mus musculus	185-193
27753791-8	2017	In addition, in vitro experiments revealed that both TPPU and EETs (11,12-EET and 14,15-EET) suppressed the expression of IL-1beta and TNF-alpha, and LDH release in RAW264.7 cells.	TPPU	53-57	interleukin 1 beta	Mus musculus	122-130
28487022-6	2017	In the female placentas, 4X (versus 1X) choline modulated the transcript expression of Il1b in a biphasic pattern with reduced Il1b at E12.5 (P = 0.045) and E18.5 (P = 0.067) but increased Il1b at E15.5 (P = 0.031).	Choline	40-47	interleukin 1 beta	Mus musculus	127-131
27753791-8	2017	In addition, in vitro experiments revealed that both TPPU and EETs (11,12-EET and 14,15-EET) suppressed the expression of IL-1beta and TNF-alpha, and LDH release in RAW264.7 cells.	eets	62-66	interleukin 1 beta	Mus musculus	122-130
28487022-6	2017	In the female placentas, 4X (versus 1X) choline modulated the transcript expression of Il1b in a biphasic pattern with reduced Il1b at E12.5 (P = 0.045) and E18.5 (P = 0.067) but increased Il1b at E15.5 (P = 0.031).	Choline	40-47	interleukin 1 beta	Mus musculus	127-131
28427134-16	2017	The mRNA expressions of TNF-alpha and IL-1beta of cells in LPS control group were 2.97+-0.17 and 3.07+-0.60, respectively, while those in BMX-IN-1+ LPS group were 2.31+-0.94 and 2.55+-0.73, respectively, with the 4 values significantly higher than those in blank control group (with P values below 0.01).	lps	59-62	interleukin 1 beta	Mus musculus	38-46
27753791-8	2017	In addition, in vitro experiments revealed that both TPPU and EETs (11,12-EET and 14,15-EET) suppressed the expression of IL-1beta and TNF-alpha, and LDH release in RAW264.7 cells.	11,12-epoxy-5,8,14-eicosatrienoic acid	68-77	interleukin 1 beta	Mus musculus	122-130
27753791-8	2017	In addition, in vitro experiments revealed that both TPPU and EETs (11,12-EET and 14,15-EET) suppressed the expression of IL-1beta and TNF-alpha, and LDH release in RAW264.7 cells.	14,15-epoxy-5,8,11-eicosatrienoic acid	82-91	interleukin 1 beta	Mus musculus	122-130
28363255-13	2017	Serum levels of thyroglobulin antibodies, HMGB1, tumor necrosis factor alpha, IL-6, and IL-1beta were significantly increased in the NaI group, but they were dramatically attenuated with GL injection.	Sodium Iodide	133-136	interleukin 1 beta	Mus musculus	88-96
28363255-13	2017	Serum levels of thyroglobulin antibodies, HMGB1, tumor necrosis factor alpha, IL-6, and IL-1beta were significantly increased in the NaI group, but they were dramatically attenuated with GL injection.	Glycyrrhizic Acid	187-189	interleukin 1 beta	Mus musculus	88-96
28427134-16	2017	The mRNA expressions of TNF-alpha and IL-1beta of cells in LPS control group were 2.97+-0.17 and 3.07+-0.60, respectively, while those in BMX-IN-1+ LPS group were 2.31+-0.94 and 2.55+-0.73, respectively, with the 4 values significantly higher than those in blank control group (with P values below 0.01).	lps	148-151	interleukin 1 beta	Mus musculus	38-46
28427134-17	2017	The mRNA expressions of TNF-alpha and IL-1beta of cells in BMX-IN-1+ LPS group were significantly lower than those in LPS control group (with P values below 0.05).	lps	69-72	interleukin 1 beta	Mus musculus	38-46
28427134-17	2017	The mRNA expressions of TNF-alpha and IL-1beta of cells in BMX-IN-1+ LPS group were significantly lower than those in LPS control group (with P values below 0.05).	lps	118-121	interleukin 1 beta	Mus musculus	38-46
28427134-21	2017	Conclusions: BMX can increase the production of pro-inflammatory cytokines TNF-alpha and IL-1beta from mouse mononuclear-macrophages induced by LPS, which may be associated with the activation of the p38MAPK pathway by BMX.	lps	144-147	interleukin 1 beta	Mus musculus	89-97
28694755-3	2017	TTH significantly decreased the production of nitric oxide (NO), prostaglandin E2 (PGE2), interleukin (IL)-6, and IL-1beta in LPS-stimulated RAW 264.7 cells.	tth	0-3	interleukin 1 beta	Mus musculus	114-122
28423560-7	2017	LPS-induced TNF-alpha, IL-6 and IL-1beta production were markedly suppressed by treatment of geraniin.	Geraniin	93-101	interleukin 1 beta	Mus musculus	32-40
28245985-4	2017	We demonstrated that 4-PBA, which further prevented the activation of the NF-kappaB pathway, decreased the release of the pro-inflammatory mediators IL-1beta, TNF-alpha and IL-6, significantly inhibited LPS-activated ER stress.	4-phenylbutyric acid	21-26	interleukin 1 beta	Mus musculus	149-157
28376889-3	2017	The uptake of monosodium urate (MSU) crystals by macrophages can lead to activation of NOD-like receptors containing a PYD 3 (NLRP3) inflammasome, thus accelerating interleukin (IL)-1beta production.	Uric Acid	14-30	interleukin 1 beta	Mus musculus	165-187
28376889-3	2017	The uptake of monosodium urate (MSU) crystals by macrophages can lead to activation of NOD-like receptors containing a PYD 3 (NLRP3) inflammasome, thus accelerating interleukin (IL)-1beta production.	Uric Acid	32-35	interleukin 1 beta	Mus musculus	165-187
28376889-12	2017	Procyanidins also inhibited MSU-induced activation of the NLRP3 inflammasome and increase of IL-1beta.	Proanthocyanidins	0-12	interleukin 1 beta	Mus musculus	93-101
28376889-12	2017	Procyanidins also inhibited MSU-induced activation of the NLRP3 inflammasome and increase of IL-1beta.	Uric Acid	28-31	interleukin 1 beta	Mus musculus	93-101
28274894-9	2017	Besides, antrosterol lowered hepatic inflammation and fibrosis related gene expressions, as well as serum AST/ALT values and TNF-alpha/IL-1beta contents in alcohol-diet fed mice.	antrosterol	9-20	interleukin 1 beta	Mus musculus	135-143
28439456-14	2017	ELISA assay revealed decreased levels of inflammatory response marker IL-1beta and TNF-alpha in the pancreatic tissues following metformin treatment.	Metformin	129-138	interleukin 1 beta	Mus musculus	70-78
28399878-3	2017	In this study, we observed unexpected and drastic activation of the caspase-1 inflammasome and production of IL-1beta in mouse bone marrow-derived macrophages stimulated simultaneously with SiO2 and TiO2 NPs at concentrations at which these NPs individually do not cause macrophage activation.	Silicon Dioxide	190-194	interleukin 1 beta	Mus musculus	109-117
28399878-3	2017	In this study, we observed unexpected and drastic activation of the caspase-1 inflammasome and production of IL-1beta in mouse bone marrow-derived macrophages stimulated simultaneously with SiO2 and TiO2 NPs at concentrations at which these NPs individually do not cause macrophage activation.	titanium dioxide	199-203	interleukin 1 beta	Mus musculus	109-117
28394269-5	2017	We showed that GA could suppress the expression of pro-inflammatory mediators (cyclooxygenase-2 (COX-2) and nitric oxide (NO) and pro-inflammatory cytokines (tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta) in LPS-treated mouse peritoneal macrophages, mouse macrophage RAW264.7 cells, and differentiated human monocytes (dTHP-1) in vitro.	ginkgolide A	15-17	interleukin 1 beta	Mus musculus	216-224
29926648-7	2017	Compared with I/R group, NS groups and DA group, the concentrations of IL-1beta and TNF-alpha in Dex group were significantly lower(P&lt;0.05)and the structure damages of renal tissues observed under electron microscope in Dex group were slighter.	Dextromethorphan	97-100	interleukin 1 beta	Mus musculus	71-79
28383063-7	2017	In addition, RA resulted in the reduction of the inflammatory-related cytokines, such as IL-6, IL-1beta, and IL-22, and protein levels of COX-2 and iNOS in mice with DSS-induced colitis.	rosmarinic acid	13-15	interleukin 1 beta	Mus musculus	95-103
28383063-7	2017	In addition, RA resulted in the reduction of the inflammatory-related cytokines, such as IL-6, IL-1beta, and IL-22, and protein levels of COX-2 and iNOS in mice with DSS-induced colitis.	dss	166-169	interleukin 1 beta	Mus musculus	95-103
28367997-7	2017	Furthermore, increased secretion of IL-1beta and IL-18 were detected in stomach of PFDA-treated mice, disorganized alignment of epithelial cells and inflammatory cell infiltration were also observed in the stomach tissues upon PFDA treatment.	perfluorodecanoic acid	83-87	interleukin 1 beta	Mus musculus	36-44
28367997-7	2017	Furthermore, increased secretion of IL-1beta and IL-18 were detected in stomach of PFDA-treated mice, disorganized alignment of epithelial cells and inflammatory cell infiltration were also observed in the stomach tissues upon PFDA treatment.	perfluorodecanoic acid	227-231	interleukin 1 beta	Mus musculus	36-44
27624805-7	2017	Treatment with either XAV-939 or ICG-001 effectively inhibited activation of beta-catenin and downregulated mRNA expression of beta-catenin-targeted genes in TDI-asthmatic mice, paralleled by dramatically attenuated TDI-induced hyperresponsiveness and inflammation of the airway, alleviated airway goblet cell metaplasia and collagen deposition, decreased Th2 inflammation, as well as lower levels of TGFbeta1, VEGF, HMGB1, and IL-1beta.	XAV939	22-29	interleukin 1 beta	Mus musculus	428-436
28369137-14	2017	Furthermore, proinflammatory cytokines such as IL-6, IL-8, IL-1beta were all remarkably inhibited after atorvastatin treatment.	Atorvastatin	104-116	interleukin 1 beta	Mus musculus	59-67
28373640-8	2017	Furthermore, we found that IL1beta inhibited testosterone secretion through down-regulating the gene expression of P450SCC and P450c17.	Testosterone	45-57	interleukin 1 beta	Mus musculus	27-34
28373694-4	2017	We demonstrated that TM6 (2.5, 5 and 10 nmol/g) alleviated the histological changes in the lung tissues as well as myeloperoxtidase (MPO) activity, lung W/D ratio, the production of TNF-alpha, IL-1beta and IL-6 induced by LPS.	tm6	21-24	interleukin 1 beta	Mus musculus	193-201
27624805-7	2017	Treatment with either XAV-939 or ICG-001 effectively inhibited activation of beta-catenin and downregulated mRNA expression of beta-catenin-targeted genes in TDI-asthmatic mice, paralleled by dramatically attenuated TDI-induced hyperresponsiveness and inflammation of the airway, alleviated airway goblet cell metaplasia and collagen deposition, decreased Th2 inflammation, as well as lower levels of TGFbeta1, VEGF, HMGB1, and IL-1beta.	Indocyanine Green	33-36	interleukin 1 beta	Mus musculus	428-436
28165624-10	2017	Further, EtOH-induced inflammasome activation, indicated by the presence of cleaved caspase-1 and mature IL-1beta protein, was also ameliorated in livers of MyD88LysM-KO mice.	Ethanol	9-13	interleukin 1 beta	Mus musculus	105-113
28070636-2	2017	We previously reported that reactive oxygen species (ROS) generated by the NADPH oxidase (NOX) isoform NOX-2 are involved in chondrocyte death induced by interleukin-1beta (IL-1beta).	Reactive Oxygen Species	28-51	interleukin 1 beta	Mus musculus	154-171
28223218-5	2017	We also demonstrated that OMZ-SPT can inhibit expression of the inflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 by ELISA in mice suffering from LPS-induced ALI and a mouse macrophage line (RAW264.7 cells).	omz-spt	26-33	interleukin 1 beta	Mus musculus	116-133
28122300-4	2017	5mg/kg Y-27632 was intravenously injected to inhibit the ROCK expressions.Y-27632 significantly decreased the serum levels of interleukin-6 (IL-6), IL-1beta, tumor necrosis factor-alpha (TNF-alpha) and increased IL-10 level in serum of MRL/lpr mice.	Y 27632	7-14	interleukin 1 beta	Mus musculus	148-156
28122300-4	2017	5mg/kg Y-27632 was intravenously injected to inhibit the ROCK expressions.Y-27632 significantly decreased the serum levels of interleukin-6 (IL-6), IL-1beta, tumor necrosis factor-alpha (TNF-alpha) and increased IL-10 level in serum of MRL/lpr mice.	Y 27632	74-81	interleukin 1 beta	Mus musculus	148-156
28447181-15	2017	This in vitro study showed that NALP3, ASC, IL-1beta, and caspase-1 mRNA levels were higher in the BTBR cardiofibroblasts and attenuated with Dapa.	dapagliflozin	142-146	interleukin 1 beta	Mus musculus	44-52
28070636-2	2017	We previously reported that reactive oxygen species (ROS) generated by the NADPH oxidase (NOX) isoform NOX-2 are involved in chondrocyte death induced by interleukin-1beta (IL-1beta).	Reactive Oxygen Species	28-51	interleukin 1 beta	Mus musculus	173-181
28070636-2	2017	We previously reported that reactive oxygen species (ROS) generated by the NADPH oxidase (NOX) isoform NOX-2 are involved in chondrocyte death induced by interleukin-1beta (IL-1beta).	Reactive Oxygen Species	53-56	interleukin 1 beta	Mus musculus	154-171
28070636-2	2017	We previously reported that reactive oxygen species (ROS) generated by the NADPH oxidase (NOX) isoform NOX-2 are involved in chondrocyte death induced by interleukin-1beta (IL-1beta).	Reactive Oxygen Species	53-56	interleukin 1 beta	Mus musculus	173-181
28070636-6	2017	On the other hand, the NOX inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride (AEBSF), the ROS scavenger N-acetylcysteine and an antisense oligodeoxynucleotide for Nox2 prevented the loss of proteoglycan induced by IL-1beta in highly differentiated ATDC5 cells.	4-(2-aminoethyl)benzenesulfonylfluoride	37-77	interleukin 1 beta	Mus musculus	215-223
28070636-6	2017	On the other hand, the NOX inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride (AEBSF), the ROS scavenger N-acetylcysteine and an antisense oligodeoxynucleotide for Nox2 prevented the loss of proteoglycan induced by IL-1beta in highly differentiated ATDC5 cells.	Oligodeoxyribonucleotides	139-159	interleukin 1 beta	Mus musculus	215-223
28070636-8	2017	IL-1beta-induced intra- and extracellular acidification was also suppressed by AEBSF, as was the antisense oligodeoxynucleotide for Nox2.	Oligodeoxyribonucleotides	107-127	interleukin 1 beta	Mus musculus	0-8
28031321-2	2017	Here, we report that the dextran sulfate sodium (DSS)-induced mouse model of chronic colitis is associated with increases in the serum level of IL-1beta and the colonic epithelial expression of the cell-surface heparan sulfate proteoglycan, syndecan-2.	Dextran Sulfate	25-47	interleukin 1 beta	Mus musculus	144-152
28178617-2	2017	Our data showed that shizukaol B concentration-dependently suppressed expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) in LPS-stimulated BV2 microglia.	shizukaol B	21-32	interleukin 1 beta	Mus musculus	231-248
28178617-2	2017	Our data showed that shizukaol B concentration-dependently suppressed expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) in LPS-stimulated BV2 microglia.	shizukaol B	21-32	interleukin 1 beta	Mus musculus	250-258
28031321-2	2017	Here, we report that the dextran sulfate sodium (DSS)-induced mouse model of chronic colitis is associated with increases in the serum level of IL-1beta and the colonic epithelial expression of the cell-surface heparan sulfate proteoglycan, syndecan-2.	Dextran Sulfate	49-52	interleukin 1 beta	Mus musculus	144-152
27967264-10	2017	Compared to the model group, ALF induced by LPS/GaIN was alleviated remarkably following TAM administration, as evidenced by the improvement of survival (87.5% vs. 37.5%), hepatic swell, moderate transaminases, slightly increased serum TNF-alpha, IL-1beta (P &lt; 0.05), and moderate histopathology.	Tamoxifen	89-92	interleukin 1 beta	Mus musculus	247-255
27864663-13	2017	It was found that BMSCs reduced H2O2-induced inflammatory factors IL-1beta and TNF-alpha, down-regulated intracellular oxidant factor MDA, up-regulated intracellular antioxidant factor SOD, and increased neurotrophins BDNF and CNTF expression.	Hydrogen Peroxide	32-36	interleukin 1 beta	Mus musculus	66-74
28213268-10	2017	We found that fisetin inhibited IL-1beta-induced expression of NO, PGE2, TNF-alpha, IL-6, COX-2, iNOS, MMP-3, MMP-13, ADAMTS-5.	fisetin	14-21	interleukin 1 beta	Mus musculus	32-40
28213267-5	2017	Then, we found that CUMS significantly caused interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) up-regulation, microglia, NF-kappaB signaling and NLRP3 inflammasome activation in the prefrontal cortex.	cums	20-24	interleukin 1 beta	Mus musculus	46-63
28213267-5	2017	Then, we found that CUMS significantly caused interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) up-regulation, microglia, NF-kappaB signaling and NLRP3 inflammasome activation in the prefrontal cortex.	cums	20-24	interleukin 1 beta	Mus musculus	65-73
28213268-10	2017	We found that fisetin inhibited IL-1beta-induced expression of NO, PGE2, TNF-alpha, IL-6, COX-2, iNOS, MMP-3, MMP-13, ADAMTS-5.	Dinoprostone	67-71	interleukin 1 beta	Mus musculus	32-40
28189973-6	2017	Treatment with ML also inhibited TNBS-induced expression of IL-1beta, IL-17A, and TNF.	Trinitrobenzenesulfonic Acid	33-37	interleukin 1 beta	Mus musculus	60-68
28213268-12	2017	Furthermore, fisetin significantly inhibited IL-1beta-induced SIRT1 decrease and inactivation.	fisetin	13-20	interleukin 1 beta	Mus musculus	45-53
28219839-6	2017	Treatment with sinigrin decreased IL-1beta and IL-18 production and concurrently suppressed NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and caspase-1 expression in LPS/ATP-stimulated cells, suggesting that the blocking of NLRP3 inflammasome activation prevented the production of both cytokines.	sinigrin	15-23	interleukin 1 beta	Mus musculus	34-42
28192731-5	2017	Isotrifoliol reduced LPS-mediated induction of mRNA expression of inducible nitric-oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-1beta, IL-6, tumor necrosis factor alpha (TNFalpha), and chemokines, such as chemokine (C-C motif) ligand (CCL) 2, CCL3, and CCL4.	isotrifoliol	0-12	interleukin 1 beta	Mus musculus	132-154
28160073-7	2017	The activity of NF-kappaB signaling declined sharply after the treatment with genistein, as evidenced by the inhibition of NF-kappaB-p65, phospho-NF-kappaB-p65, and phospo-IkappaB-alpha expressions, as well as the expression of IkappaB-alpha and the messenger RNA (mRNA) expression of inflammatory cytokines (MCP1, TNFalpha, IL1beta, IL4, IL10) mediated by NF-kappaB signaling pathways in the early phase of the infection.	Genistein	78-87	interleukin 1 beta	Mus musculus	325-332
28170292-6	2017	In addition, pretreatment with NAH attenuated intestinal injury, inhibited neutrophil infiltration and suppressed the production of inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6) in the intestine during sepsis, and it also significantly reduced the elevation of inflammatory cytokines in the serum 24 hr after CLP.	Niacin	31-34	interleukin 1 beta	Mus musculus	185-202
28406731-5	2017	The group supplemented with high concentrations of hyaluronic acid appeared significantly better than control group for collagen, matrix metalloproteinase 1, interleukin (IL)-1beta, and IL-6 assay.	Hyaluronic Acid	51-66	interleukin 1 beta	Mus musculus	158-180
28406732-4	2017	We found that BAB decreased the concentrations of LPS and various circulating proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 in mice with HD-induced obesity.	bab	14-17	interleukin 1 beta	Mus musculus	147-169
28113104-6	2017	The tryptophan diet ameliorated DSS-induced colitis symptoms and severity in WT mice but not in KO mice, and the diet reduced the mRNA expression of Il-6, Tnfalpha, Il-1beta and the chemokines Ccl2, Cxcl1 and Cxcl2 in the WT groups.	Tryptophan	4-14	interleukin 1 beta	Mus musculus	165-173
27888114-0	2017	Limonene reduces hyperalgesia induced by gp120 and cytokines by modulation of IL-1 beta and protein expression in spinal cord of mice.	Limonene	0-8	interleukin 1 beta	Mus musculus	78-87
27888114-8	2017	Limonene also inhibited TNF-alpha and IL-1beta-induced mechanical hyperalgesia.	Limonene	0-8	interleukin 1 beta	Mus musculus	38-46
27888114-9	2017	Western blot assay demonstrated limonene was capable of increasing SOD expression in the cytoplasm of cells from spinal cord at 4h after intrathecal IL-1beta injection.	Limonene	32-40	interleukin 1 beta	Mus musculus	149-157
27888114-10	2017	SIGNIFICANCE: These results demonstrate that gp120 causes mechanical hyperalgesia and a peripheral increase in IL-1beta and IL-10, and that prior administration of limonene inhibits these changes.	Limonene	164-172	interleukin 1 beta	Mus musculus	111-119
27888114-11	2017	Also limonene modulates the activation of SOD expression in the spinal cord after spinal IL-1beta application.	Limonene	5-13	interleukin 1 beta	Mus musculus	89-97
27888114-12	2017	The ability of limonene to inhibit the mechanical hyperalgesia induced by gp120, TNF-alpha and IL-1beta emphasizes the anti-inflammatory action of limonene, specifically its ability to inhibit cytokine production and its consequences.	Limonene	15-23	interleukin 1 beta	Mus musculus	95-103
27888114-12	2017	The ability of limonene to inhibit the mechanical hyperalgesia induced by gp120, TNF-alpha and IL-1beta emphasizes the anti-inflammatory action of limonene, specifically its ability to inhibit cytokine production and its consequences.	Limonene	147-155	interleukin 1 beta	Mus musculus	95-103
27965141-7	2017	Real time polymerase chain reaction assay indicated that administration of PG after SCI down-regulated the expression of pro-inflammatory cytokines MCP-1, NOS2, and IL-1beta (P &lt; 0.05).	Progesterone	75-77	interleukin 1 beta	Mus musculus	165-173
27997528-10	2017	Moreover, IL-1beta, IL-10, and MCP-1 levels were significantly decreased by IVIG+losartan.	Losartan	81-89	interleukin 1 beta	Mus musculus	10-18
28373844-8	2017	Moreover, we found that ketamine increased the hippocampal levels of IL-6 and IL-1beta after single, multiple and long-term administration in a dose-dependent manner.	Ketamine	24-32	interleukin 1 beta	Mus musculus	78-86
27648694-8	2017	Strikingly, CLP mice treated with GdCl3 were protected against liver injury as evidenced by decreased LSECs defenestration and damage, MPO, ALT and AST activities, liver tissue damage, and inflammatory cytokines TNF-alpha, IL-6 and IL-1beta, and chemokines MCP-1 and MIP-2alpha.	gadolinium chloride	34-39	interleukin 1 beta	Mus musculus	232-240
28395719-10	2017	Results In the alphacalcidol combined with dexamethasone group, IL-1beta, IL-6, TNF-alpha and TGF-beta1, cell count, Sazpiel score, Hyp values were lower than those in the other groups except for the control group, and the alveolar inflammation and fibrin deposition were also lower than those in the other groups except for the control group.	alfacalcidol	15-28	interleukin 1 beta	Mus musculus	64-72
28333137-7	2017	In addition, the expression of pro-inflammatory cytokines IL-1beta and IFN-gamma mRNA was downregulated while the expression of TGF-beta1 and Foxp3 mRNA was upregulated in kidney tissue after transferring rapamycin-treated MDSCs.	Sirolimus	205-214	interleukin 1 beta	Mus musculus	58-66
28333137-8	2017	Adoptive transfer of rapamycin-treated MDSCs also downregulated the serum levels of IL-1beta, IL-6 and IFN-gamma and upregulated the serum levels of TGF-beta1 compared with the IR group and PBS-treated MDSC group.	Sirolimus	21-30	interleukin 1 beta	Mus musculus	84-92
28223539-7	2017	In vitro, we observed that thymol dose-dependently inhibited the expression of TNF-alpha, IL-1beta, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) in LPS-stimulated RAW264.7 cells.	Thymol	27-33	interleukin 1 beta	Mus musculus	90-98
28373844-12	2017	Our results suggest that the alterations in the levels of inflammatory cytokines IL-6, IL-1beta, and TNF-alpha may be involved in the neurotoxicity of ketamine.	Ketamine	151-159	interleukin 1 beta	Mus musculus	87-95
27943364-8	2017	Pretreatment with butyrate led to significant attenuation of the LPS-induced elevation of TNF-alpha, IL-6 and IL-1beta levels.	Butyrates	18-26	interleukin 1 beta	Mus musculus	110-118
27943364-10	2017	Pretreatment of RAW 264.7 cells with butyrate led to downregulation of LPS-induced pro-inflammatory mediators, IL-6 and IL-1beta, but did not affect the level of TNF-alpha, and increased IL-10 (P &lt; 0.01).	Butyrates	37-45	interleukin 1 beta	Mus musculus	120-128
28202417-7	2017	Triptolide treatment attenuated TAC-induced myocardial remodeling, improved cardiac diastolic and systolic function, inhibited the NLRP3 inflammasome and downstream inflammatory mediators (IL-1beta, IL-18, MCP-1, VCAM-1), activated the profibrotic TGF-beta1 pathway, and suppressed macrophage infiltration in a dose-dependent manner.	triptolide	0-10	interleukin 1 beta	Mus musculus	189-197
28178069-5	2017	In the present study, our results showed that treatment with montelukast could protect DA neurons against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity and its administration significantly attenuated the production of neurotoxic cytokines such as tumor necrosis factor-alpha (TNFalpha) and interleukin-1beta (IL-1beta) from activated microglia in the substantia nigra (SN) and striatum following 6-OHDA treatment.	montelukast	61-72	interleukin 1 beta	Mus musculus	293-310
28356707-9	2017	While NMDA treatment dramatically upregulated mRNAs of inflammatory cytokines (TNFalpha, IL-1beta, MCP-1, RANTES) in retinal homogenates, co-injection with JQ1 suppressed their upregulation by ~50%.	N-Methylaspartate	6-10	interleukin 1 beta	Mus musculus	89-97
28386326-7	2017	We found that Ach inhibited LPS-induced IL-1beta and IL-6 elevation and promoted IL-4 and IL-10 production and that knockdown of the alpha7 nAChR abolished these effects of Ach.	Acetylcholine	14-17	interleukin 1 beta	Mus musculus	40-48
28511297-8	2017	There was a large number of IL-1beta and TNF-alpha protein expression in kidney tissue in TCE sensitized group and TCE+C3aRA sensitized group.	Trichloroethylene	90-93	interleukin 1 beta	Mus musculus	28-36
28511297-9	2017	Compared with the TCE sensitized group, the expression level of IL-1beta and TNF-alpha protein in kidney tissue in TCE+C3aRA sensitized group was significantly decreased (P&lt;0.05) .	Trichloroethylene	18-21	interleukin 1 beta	Mus musculus	64-72
28511297-9	2017	Compared with the TCE sensitized group, the expression level of IL-1beta and TNF-alpha protein in kidney tissue in TCE+C3aRA sensitized group was significantly decreased (P&lt;0.05) .	Trichloroethylene	115-118	interleukin 1 beta	Mus musculus	64-72
28386354-7	2017	Silencing of miR-1246 prevented LPS-induced inhibition of ACE2, which was accompanied by reduced apoptosis and production of IL-1beta and TNF-alpha.	mir-1246	13-21	interleukin 1 beta	Mus musculus	125-133
28386354-8	2017	In contrast, ectopic expression of miR-1246 triggered apoptosis in PMVECs and promoted IL-1beta and TNF-alpha release.	mir-1246	35-43	interleukin 1 beta	Mus musculus	87-95
28298636-5	2017	We further demonstrate that P2X5 is required for ATP-mediated inflammasome activation and IL-1beta production by OCs, and that P2X5-deficient OC maturation is rescued in vitro by addition of exogenous IL-1beta.	Adenosine Triphosphate	49-52	interleukin 1 beta	Mus musculus	201-209
28069457-10	2017	Further, CUS elevated the levels of oxidative stress markers (TBARS, nitric oxide), lowered antioxidants (total thiol, catalase), enhanced expression of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta and COX-2) in the hippocampus and damaged hippocampal neurons.	cus	9-12	interleukin 1 beta	Mus musculus	198-206
28316773-6	2017	We co-administered the hormonally active form of vitamin D, 1alpha,25 dihydroxy vitamin D3 (1,25OHD), simultaneously with poly(I:C) and examined (i) social interaction, stereotyped behavior, emotional learning and memory, and innate anxiety-like behavior in juveniles and (ii) the levels of the pro-inflammatory cytokines IL-1beta, IL-6 and TNF-alpha in maternal plasma and fetal brains.	Vitamin D	49-58	interleukin 1 beta	Mus musculus	322-330
28153725-7	2017	Pretreatment with AMG9810 or CPZ significantly suppressed the release of IL-6, IL-1beta and IL-18, and COX-2 expression, whereas SB366791 and BCTC were less effective.	3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide	18-25	interleukin 1 beta	Mus musculus	79-87
28153725-7	2017	Pretreatment with AMG9810 or CPZ significantly suppressed the release of IL-6, IL-1beta and IL-18, and COX-2 expression, whereas SB366791 and BCTC were less effective.	capsazepine	29-32	interleukin 1 beta	Mus musculus	79-87
28126590-5	2017	Glial fibrillary acidic protein immunohistochemistry and quantitative polymerase chain reaction analysis revealed that astroglial activation and tumor necrosis factor alpha, inducible nitric oxide synthase, and interleukin 1 beta production were significantly inhibited by FCE.	FCE	273-276	interleukin 1 beta	Mus musculus	211-229
28266627-6	2017	Furthermore, endogenous ATP and caspase-1 were required for mature IL-1beta production stimulated by CCN1 in keratinocytes.	Adenosine Triphosphate	24-27	interleukin 1 beta	Mus musculus	67-75
28253885-10	2017	RESULTS: Dh404 significantly attenuated endothelial dysfunction in diabetic Akita mice characterized by reduced contraction in response to phenylephrine and the downregulation of inflammatory genes (VCAM-1, ICAM-1, p65, IL-1beta) and pro-oxidant genes (Nox1 and Nox2).	dh404	9-14	interleukin 1 beta	Mus musculus	220-228
28273882-7	2017	Treatment with NLRP3 inhibitors using NaB and HBA preserved corneal clarity and decreased NLRP3, caspase-1, and IL-1beta mRNA transcripts, as well as NLRP3 protein expression on post-injury compared to BSS-treated corneas.	nab	38-41	interleukin 1 beta	Mus musculus	112-120
28259154-9	2017	CTEtOH (0.5 and 1.0 g/kg) reduced the levels of malondialdehyde, nitric oxide, and proinflammatory cytokines (TNF-alpha and IL-1beta).	ctetoh	0-6	interleukin 1 beta	Mus musculus	124-132
28089560-9	2017	Mice with surgery and anesthesia had increased ionized calcium binding adapter molecule 1 and interleukin 1beta in the hippocampus but this increase was smaller in mice anesthetized with desflurane than mice anesthetized with isoflurane.	Desflurane	187-197	interleukin 1 beta	Mus musculus	94-111
28303105-9	2017	The CR + Cisplatin group exhibited reduced serum IL-1beta and TNF-alpha levels.	cr + cisplatin	4-18	interleukin 1 beta	Mus musculus	49-57
28424540-4	2017	MC4 showed stronger inhibitory effects than FK866 on CLP-induced mortality, serum tumor necrosis factor alpha (TNFalpha) levels, pulmonary myeloperoxidase activity, alveolar injury, and interleukin 6 and interleukin1beta messenger RNA levels.	SCHEMBL639538	0-3	interleukin 1 beta	Mus musculus	204-220
28068635-6	2017	Interestingly, the IP6 was found to down-regulate the mRNA expression of tumor necrosis factor (TNF)-alpha, Interleukin (IL)-1beta, and IL-6 in iron overloaded liver tissues.	Phytic Acid	19-22	interleukin 1 beta	Mus musculus	108-130
28068635-6	2017	Interestingly, the IP6 was found to down-regulate the mRNA expression of tumor necrosis factor (TNF)-alpha, Interleukin (IL)-1beta, and IL-6 in iron overloaded liver tissues.	Iron	144-148	interleukin 1 beta	Mus musculus	108-130
28007523-5	2017	The optimal dose of pinocembrin (5mg/kg) suppressed microglial activation as evidenced by decreases in CD68-positive microglia and reduced proinflammatory cytokines tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6.	pinocembrin	20-31	interleukin 1 beta	Mus musculus	200-222
28096316-11	2017	BAY 11-7082 reduced pNF-kappaB, NLRP3, tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and IL-1beta expression, blunted the phosphorylation of signal transducer and activators of transcription 3 (STAT3) and decreased IL-23 levels.	3-(4-methylphenylsulfonyl)-2-propenenitrile	0-11	interleukin 1 beta	Mus musculus	104-112
28038748-5	2017	The immunomodulatory assay exhibited that JSP-11 could significantly enhance the viability of RAW 264.7 macrophage cells, and promote the release of NO, TNF-alpha, and IL-1beta via activating NF-kappaB, MAPKs and PI3K/Akt signal pathways.	jsp-11	42-48	interleukin 1 beta	Mus musculus	168-176
28011397-10	2017	Moreover, 3-methoxy-catalposide markedly reduced the LPS-induced expression of pro-inflammatory genes, such as interleukin (IL)-6, IL-1beta, and TNF-alpha.	3-methoxy-catalposide	10-31	interleukin 1 beta	Mus musculus	131-139
28484748-3	2017	Tangeretin decreased nitric oxide production and the expression of interleukin (IL)-6, IL-1beta, tumor necrosis factor-alpha, inducible nitric oxide synthase, and cyclooxygenase-2 in a coculture of 3T3-L1 adipocytes and RAW 264.7 cells.	tangeretin	0-10	interleukin 1 beta	Mus musculus	87-124
27601185-6	2017	The ATP-degradating enzyme attenuated the release of ATP and IL-1beta.	Adenosine Triphosphate	4-7	interleukin 1 beta	Mus musculus	61-69
27601185-8	2017	These results strongly suggest that S. sanguinis has the activity to induce IL-1beta through the NLRP3 inflammasome in macrophage and DC and interaction of purinergic receptors with ATP released is involved in expression of the activity.	Adenosine Triphosphate	182-185	interleukin 1 beta	Mus musculus	76-84
28132925-6	2017	Furthermore, both NADPH and apocynin suppressed the expression of inflammasome proteins including NLRP3 ASC, caspase-1, interleukin (IL)-1beta and IL-18 in the ischemic cortex as revealed by Western blot analysis and immunofluorescence.	NADP	18-23	interleukin 1 beta	Mus musculus	120-142
27701898-6	2017	Intraplantar treatment with clazosentan, but not BQ-788, reduced spinal (71%) and peripheral (51%) interleukin-1 beta as well as spinal (59%) and peripheral (50%) tumor necrosis factor-alpha production.	clazosentan	28-39	interleukin 1 beta	Mus musculus	99-117
28110063-6	2017	In addition, curcumin treatment markedly reduced the hepatic protein expression of oxidative stress, pro-inflammatory cytokines, and chemokines including interferon (IFN) gamma, interleukin-1beta and IFNgamma-inducible protein 10, in NASH mice.	Curcumin	13-21	interleukin 1 beta	Mus musculus	178-195
28400838-5	2017	HemoHIM reduced the inflammatory cell count and levels of tumor necrosis factor receptor (TNF)-alpha, interleukin (IL)-6 and IL-1beta in the broncho-alveolar lavage fluid (BALF) induced by CS+LPS exposure.	Cesium	189-191	interleukin 1 beta	Mus musculus	125-133
28148737-4	2017	Antenatal exposure to IL-1beta induced Tnfa, Il6, Ccl2, Pghs2, and Mpges1 expression in placenta and fetal membranes, and it elevated amniotic fluid IL-1beta, IL-6, IL-8, and PGF2alpha, resulting in PTB and marked neonatal mortality.	Dinoprost	175-184	interleukin 1 beta	Mus musculus	22-30
28395089-5	2017	MMA-injected mice showed increased levels of the reactive oxygen species marker 2",7"-dichlorofluorescein diacetate, tumor necrosis factor, interleukin-1beta, caspases 1, 3, and 8, and increased acetylcholinesterase activity in the cortex, hippocampus and striatum.	Methylmalonic Acid	0-3	interleukin 1 beta	Mus musculus	140-179
28127806-3	2017	EPS suppressed LPS-induced nitric oxide, prostaglandin E2 , TNF-alpha, interleukin-6 and interleukin-1beta at production and mRNA levels in LPS-induced RAW 264.7 macrophages.	eps	0-3	interleukin 1 beta	Mus musculus	89-106
26801190-8	2017	Moreover, PPX inhibited the production of inflammatory cytokines, such as IL-17, IL-1beta, and TNF-alpha in peripheral lymphoid tissue.	Pramipexole	10-13	interleukin 1 beta	Mus musculus	81-89
28092375-6	2017	IL-1beta and insulin increased the uptake of glucose into macrophages, and insulin reinforced a pro-inflammatory pattern via the insulin receptor, glucose metabolism, production of reactive oxygen species, and secretion of IL-1beta mediated by the NLRP3 inflammasome.	Reactive Oxygen Species	181-204	interleukin 1 beta	Mus musculus	0-8
28092375-0	2017	Postprandial macrophage-derived IL-1beta stimulates insulin, and both synergistically promote glucose disposal and inflammation.	Glucose	94-101	interleukin 1 beta	Mus musculus	32-40
28092375-2	2017	However, a possible physiological role for IL-1beta in glucose metabolism has remained unexplored.	Glucose	55-62	interleukin 1 beta	Mus musculus	43-51
28092375-3	2017	Here we found that feeding induced a physiological increase in the number of peritoneal macrophages that secreted IL-1beta, in a glucose-dependent manner.	Glucose	129-136	interleukin 1 beta	Mus musculus	114-122
28092375-6	2017	IL-1beta and insulin increased the uptake of glucose into macrophages, and insulin reinforced a pro-inflammatory pattern via the insulin receptor, glucose metabolism, production of reactive oxygen species, and secretion of IL-1beta mediated by the NLRP3 inflammasome.	Glucose	45-52	interleukin 1 beta	Mus musculus	0-8
28092375-6	2017	IL-1beta and insulin increased the uptake of glucose into macrophages, and insulin reinforced a pro-inflammatory pattern via the insulin receptor, glucose metabolism, production of reactive oxygen species, and secretion of IL-1beta mediated by the NLRP3 inflammasome.	Glucose	45-52	interleukin 1 beta	Mus musculus	223-231
28092375-6	2017	IL-1beta and insulin increased the uptake of glucose into macrophages, and insulin reinforced a pro-inflammatory pattern via the insulin receptor, glucose metabolism, production of reactive oxygen species, and secretion of IL-1beta mediated by the NLRP3 inflammasome.	Glucose	147-154	interleukin 1 beta	Mus musculus	0-8
27654963-9	2017	RESULTS: Synovial IL-1beta expression was strongly elevated 7 days after induction of CiOA in WT mice but decreased afterwards, whereas S100A8/A9, previously described to aggravate OA, remained elevated for 21 days.	cioa	86-90	interleukin 1 beta	Mus musculus	18-26
29979844-6	2017	We found that Api did not affect splenocyte viability, butinhibited the production of pro-inflammatory cytokine IL-1beta, IL-6 and TNF-alpha, not anti-inflammatory cytokineIL-10.	Apigenin	14-17	interleukin 1 beta	Mus musculus	112-120
28289409-3	2017	Similar increases in gene expression of NLRP3, apoptosis associated speck like protein (ASC) and pro-IL-1beta were induced by multiple low doses of streptozotocin (STZ) in C57BL/6 mice.	Streptozocin	164-167	interleukin 1 beta	Mus musculus	101-109
28289409-12	2017	Overall, our results demonstrate that mDNA-mediated NLRP3 activation triggers caspase-1-dependent IL-1beta production and contributes to pathogenic cellular responses during the development of STZ-induced T1D.	Streptozocin	193-196	interleukin 1 beta	Mus musculus	98-106
28293084-9	2017	Inflammatory factors were assessed, and the results showed that the DSS + HRW group exhibited significantly reduced levels of TNF-alpha, IL-6 and IL-1beta compared with the DSS group (P &lt; 0.05).	Dextran Sulfate	68-71	interleukin 1 beta	Mus musculus	146-154
28233796-3	2017	We demonstrate the mechanism involves the antioxidant and anti-inflammatory abilities of ZnONPs to suppress ROS and malondialdehyde (MDA) production; increase GSH level; suppress proinflammatory cytokines IL-1beta and TNF-alpha and myeloperoxidase (MPO).	znonps	89-95	interleukin 1 beta	Mus musculus	205-213
28289409-3	2017	Similar increases in gene expression of NLRP3, apoptosis associated speck like protein (ASC) and pro-IL-1beta were induced by multiple low doses of streptozotocin (STZ) in C57BL/6 mice.	Streptozocin	148-162	interleukin 1 beta	Mus musculus	101-109
28216638-3	2017	TQ strongly inhibited the production of nitric oxide (NO) and repressed NO synthase (iNOS), tumor necrosis factor (TNF)-alpha, cyclooxygenase (COX)-2, interleukin (IL)-6, and IL-1beta expression in LPS-activated RAW264.7 cells.	thymoquinone	0-2	interleukin 1 beta	Mus musculus	175-183
28219355-7	2017	RESULTS: In this study, we demonstrated that vaccaria hypaphorine dramatically ameliorated LPS-induced nitric oxide (NO) release and productions of proinflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, IL-10, monocyte chemoattractant protein 1 (MCP-1) and prostaglandin E2 (PGE2) in RAW 264.7 cells.	lenticin	54-65	interleukin 1 beta	Mus musculus	225-242
28219355-7	2017	RESULTS: In this study, we demonstrated that vaccaria hypaphorine dramatically ameliorated LPS-induced nitric oxide (NO) release and productions of proinflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, IL-10, monocyte chemoattractant protein 1 (MCP-1) and prostaglandin E2 (PGE2) in RAW 264.7 cells.	lenticin	54-65	interleukin 1 beta	Mus musculus	244-252
28275298-11	2017	The expression levels of IL-1beta, IL-8 and TNF-alpha in the DSS group were higher than those in the control group (P &lt; 0.05), and the expression levels of IL-1beta, IL-8 and TNF-alpha in the JPQCD and 5-ASA groups were lower than those in the DSS group after treating with JPQCD and 5-ASA.	Dextran Sulfate	61-64	interleukin 1 beta	Mus musculus	25-33
28275298-11	2017	The expression levels of IL-1beta, IL-8 and TNF-alpha in the DSS group were higher than those in the control group (P &lt; 0.05), and the expression levels of IL-1beta, IL-8 and TNF-alpha in the JPQCD and 5-ASA groups were lower than those in the DSS group after treating with JPQCD and 5-ASA.	Mesalamine	205-210	interleukin 1 beta	Mus musculus	159-167
28104349-7	2017	In vitro study, the results showed that IA inhibited production of IL-1beta, IL-6 and TNF-alpha at transcriptional and translational levels in RAW 264.7 cells induced by LPS.	lps	170-173	interleukin 1 beta	Mus musculus	67-75
28275298-11	2017	The expression levels of IL-1beta, IL-8 and TNF-alpha in the DSS group were higher than those in the control group (P &lt; 0.05), and the expression levels of IL-1beta, IL-8 and TNF-alpha in the JPQCD and 5-ASA groups were lower than those in the DSS group after treating with JPQCD and 5-ASA.	Dextran Sulfate	247-250	interleukin 1 beta	Mus musculus	159-167
28275298-11	2017	The expression levels of IL-1beta, IL-8 and TNF-alpha in the DSS group were higher than those in the control group (P &lt; 0.05), and the expression levels of IL-1beta, IL-8 and TNF-alpha in the JPQCD and 5-ASA groups were lower than those in the DSS group after treating with JPQCD and 5-ASA.	Mesalamine	287-292	interleukin 1 beta	Mus musculus	159-167
28275298-12	2017	Comparing with the DSS group, the mRNA level of IL-1beta, IL-8, TNF-alpha and NF-kappaB was significantly reduced by 5-ASA and JPQCD.	Dextran Sulfate	19-22	interleukin 1 beta	Mus musculus	48-56
28275298-12	2017	Comparing with the DSS group, the mRNA level of IL-1beta, IL-8, TNF-alpha and NF-kappaB was significantly reduced by 5-ASA and JPQCD.	Mesalamine	117-122	interleukin 1 beta	Mus musculus	48-56
28211545-4	2017	ABX significantly reduced gut bacteria and prevented chronic morphine induced increases in gut permeability, colonic mucosal destruction, and colonic IL-1beta expression.	CHEMBL369125	0-3	interleukin 1 beta	Mus musculus	150-158
28211545-4	2017	ABX significantly reduced gut bacteria and prevented chronic morphine induced increases in gut permeability, colonic mucosal destruction, and colonic IL-1beta expression.	Morphine	61-69	interleukin 1 beta	Mus musculus	150-158
28207754-0	2017	Ascofuranone inhibits lipopolysaccharide-induced inflammatory response via NF-kappaB and AP-1, p-ERK, TNF-alpha, IL-6 and IL-1beta in RAW 264.7 macrophages.	ascofuranone	0-12	interleukin 1 beta	Mus musculus	122-130
28017669-12	2017	Moreover, astaxanthin could down-regulate the expression of IL-6, IL-1beta and COX-2 in the hippocampus.	astaxanthine	10-21	interleukin 1 beta	Mus musculus	66-74
27720931-6	2017	STZ-induced memory impairment was also accompanied by an elevated level of hippocampal CysLT1R, microglial activation, increased IL-1beta, and TNF-alpha.	Streptozocin	0-3	interleukin 1 beta	Mus musculus	129-137
28109817-5	2017	Salecan treatment significantly reduced ConA-induced acute liver injury, and suppressed the expression and secretion of inflammatory cytokines including interferon (IFN)-gamma, interleukin (IL)-6 and IL-1beta in ConA-induced liver injury model.	salecan	0-7	interleukin 1 beta	Mus musculus	200-208
28208679-9	2017	The in vitro studies demonstrated that vanillin reduces LPS-induced expression of inducible nitric oxide (iNOS), cyclooxygenase-2 (COX-2), IL-1beta, and IL-6 through regulating ERK1/2, p38 and NF-kappaB signaling.	vanillin	39-47	interleukin 1 beta	Mus musculus	139-147
28265343-11	2017	Palmitate upregulated NLRP3 and IL1beta expression in primary Muller cells isolated from wild type.	Palmitates	0-9	interleukin 1 beta	Mus musculus	32-39
28265343-12	2017	However, using primary Muller cells isolated from thioredoxin interacting protein knock-out mice abolished palmitate-mediated increase in NLRP3 and IL1beta.	Palmitates	107-116	interleukin 1 beta	Mus musculus	148-155
27881407-10	2017	Finally, sakuranetin treatment also reduced total protein, and the levels of TNF-alpha and IL-1beta in the lung.	sakuranetin	9-20	interleukin 1 beta	Mus musculus	91-99
27793708-9	2017	In primary mouse bone marrow-derived macrophages (BMDM), ChS-exposure increased the secretion of IL-1beta, TNF-alpha and IL-6.	cholesteryl succinate	57-60	interleukin 1 beta	Mus musculus	97-105
27909955-6	2017	Data demonstrate that DAB induced potent inhibition of PMA-, TNF-alpha-, IL-1beta- (in HUVECs), and CLP-induced EPCR shedding (in mice) via inhibition of phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38, janus kinase (JNK), and extracellular signal-regulated kinase (ERK) 1/2.	dabrafenib	22-25	interleukin 1 beta	Mus musculus	73-81
27862161-8	2017	beta-eudesmol suppresses the serum levels of histamine, IgE, interleukin (IL)-1beta, IL-4, IL-5, IL-6, IL-13, and vascular endothelial growth factor (VEGF) under PCA mice as well as PCA reactions.	beta-eudesmol	0-13	interleukin 1 beta	Mus musculus	61-83
27978494-6	2017	Sal also inhibited the generations of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in serum and lungs.	rhodioloside	0-3	interleukin 1 beta	Mus musculus	141-158
27978494-6	2017	Sal also inhibited the generations of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in serum and lungs.	rhodioloside	0-3	interleukin 1 beta	Mus musculus	160-168
27375005-0	2017	The involvement of prostaglandin E2 in interleukin-1beta evoked anorexia is strain dependent.	Dinoprostone	19-35	interleukin 1 beta	Mus musculus	39-56
27375005-6	2017	We conclude that the involvement of induced PGE2 in IL-1beta evoked anorexia is strain dependent and we suggest that different routes that probably involve distinct prostanoids exist by which inflammatory stimuli may evoke an anorexic response and that these routes may be of different importance in different strains of mice.	Dinoprostone	44-48	interleukin 1 beta	Mus musculus	52-60
27375005-6	2017	We conclude that the involvement of induced PGE2 in IL-1beta evoked anorexia is strain dependent and we suggest that different routes that probably involve distinct prostanoids exist by which inflammatory stimuli may evoke an anorexic response and that these routes may be of different importance in different strains of mice.	Prostaglandins	165-176	interleukin 1 beta	Mus musculus	52-60
27579991-6	2017	The anti-inflammatory properties of erythropoietin in the TNBS-induced colitis were confirmed by suppression of pro-inflammatory mediators, such as TNF-alpha, IL-1beta and MPO, as well as a significant increase in the anti-inflammatory cytokine, IL-10, was promoted.	Trinitrobenzenesulfonic Acid	58-62	interleukin 1 beta	Mus musculus	159-167
27888016-8	2017	Furthermore, cyclophosphamide prevented the surge of IL-1beta, GVHD aggravation, and sudden death associated with prolonged administration of ixazomib after HSCT.	Cyclophosphamide	13-29	interleukin 1 beta	Mus musculus	53-61
28112987-9	2017	GA also blocked interleukin (IL)-1beta by reducing the activity of caspase-1 in the NHEKs.	glycolic acid	0-2	interleukin 1 beta	Mus musculus	16-38
27749344-9	2017	Additionally we report, in vitro, that increased concentrations of active caspase-1 and interleukin-1beta are related to an increased concentration of hydrogen peroxide in bacterially infected glutathione peroxidase 1 macrophages and that restoring hydrogen peroxide antioxidant defenses suppressed this effect.	Hydrogen Peroxide	151-168	interleukin 1 beta	Mus musculus	88-105
27749344-9	2017	Additionally we report, in vitro, that increased concentrations of active caspase-1 and interleukin-1beta are related to an increased concentration of hydrogen peroxide in bacterially infected glutathione peroxidase 1 macrophages and that restoring hydrogen peroxide antioxidant defenses suppressed this effect.	Hydrogen Peroxide	249-266	interleukin 1 beta	Mus musculus	88-105
27474370-9	2017	CD40 ligation in Muller cells triggered phospholipase C-dependent ATP release that caused P2X7-dependent production of TNF-alpha and IL-1beta by macrophages.	Adenosine Triphosphate	66-69	interleukin 1 beta	Mus musculus	133-141
28112987-11	2017	The photoprotective activity of GA was ascribed to the inhibition of ROS formation and DNA damage, as well as a reduction in the activities of inflammasome complexes and IL-1beta.	glycolic acid	32-34	interleukin 1 beta	Mus musculus	170-178
27817102-8	2017	Moreover, increased placental TNF-alpha, IL-1beta, and IL-6 expressions in LPS-treated group were significantly suppressed after curcumin administration.	Curcumin	129-137	interleukin 1 beta	Mus musculus	41-49
27778057-5	2017	In the TNBS model was observed reduction in macroscopic and microscopic score, colon weight, neutrophil influx, IL-1beta, MIP-2 and keratinocyte chemoattractant (KC) levels, inhibition of adhesion molecules expression and restoration of IL-10 levels.	Trinitrobenzenesulfonic Acid	7-11	interleukin 1 beta	Mus musculus	112-120
27696333-10	2017	TPPU also decreased downstream signal from TREM-1, reducing pro-inflammatory cytokine TNF-alpha and IL-1beta mRNA expression.	TPPU	0-4	interleukin 1 beta	Mus musculus	100-108
28054242-6	2017	We observed that SFN dose-dependently attenuated CCI-induced pain behavioral hypersensitivity, accompanied by reduction in pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and upregulation of an anti-inflammatory cytokine (IL-10).	sulforaphane	17-20	interleukin 1 beta	Mus musculus	162-170
27978459-9	2017	The inflammatory mediators TNFalpha, IL-1beta, p-STAT3 and p-NF-kappaB induced in the colon by DSS were markedly suppressed by LC.	Dextran Sulfate	95-98	interleukin 1 beta	Mus musculus	37-45
28146407-7	2017	In addition, BSCME induced the expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in RAW 264.7 cells in a dose-dependent manner.	bscme	13-18	interleukin 1 beta	Mus musculus	89-106
27733575-7	2017	Furthermore, we show that a culture of AECs with either fenoldopam or the AMPK activator metformin effectively diminished IL-1beta-induced release of adverse paracrine signaling, which promotes the macrophage proinflammatory response.	Fenoldopam	56-66	interleukin 1 beta	Mus musculus	122-130
27733575-7	2017	Furthermore, we show that a culture of AECs with either fenoldopam or the AMPK activator metformin effectively diminished IL-1beta-induced release of adverse paracrine signaling, which promotes the macrophage proinflammatory response.	Metformin	89-98	interleukin 1 beta	Mus musculus	122-130
28146407-7	2017	In addition, BSCME induced the expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in RAW 264.7 cells in a dose-dependent manner.	bscme	13-18	interleukin 1 beta	Mus musculus	108-116
28146407-8	2017	BSCME at 500 mug/mL increased TNF-alpha and IL-1beta mRNA levels by 83.8% and 82.2%, respectively.	bscme	0-5	interleukin 1 beta	Mus musculus	44-52
28146407-11	2017	In conclusion, BSCME exerted immunostimulatory effects, which were mediated by MAPK phosphorylation and NF-kappaB activation, resulting in increased TNF-alpha and IL-1beta gene expression in RAW 264.7 macrophages.	bscme	15-20	interleukin 1 beta	Mus musculus	163-171
27951472-8	2017	DSS increased colonic interleukin (IL)-1beta, IL-6, and monocyte chemotactic protein-1 expression.	Dextran Sulfate	0-3	interleukin 1 beta	Mus musculus	22-44
27889907-4	2017	Nur77 over-expression or application of Nur77 agonist cytosporone B suppressed the expression of proinflammatory genes, such as inducible nitric oxide NOS, cyclooxygenase-2, IL-1beta, and tumor necrosis factor-alpha in the activated microglia, while silenced Nur77 exaggerated the inflammatory responses in microglia.	cytosporone B	54-67	interleukin 1 beta	Mus musculus	174-182
27984078-5	2017	In accordance, MT-031 was shown to reduce reactive oxygen species accumulation, increase the levels of anti-inflammatory cytokines, IL-10 and decrease the levels of the pro-inflammatory cytokines, IL-1beta, IL-6, IL-17 and interferon-gamma (IFN-gamma) in activated mouse splenocytes and microglial cells.	SCHEMBL16948183	15-21	interleukin 1 beta	Mus musculus	197-205
28206680-3	2017	In the present study, it was found that ZXL1 inhibits Mtb entry into murine macrophages and that ZXL1 enhances IL-1beta and IL-12 mRNA expression and cytokine production in ManLAM-treated macrophages but decreases IL-10 production.	manlam	173-179	interleukin 1 beta	Mus musculus	111-119
28092664-4	2017	Adenine and N4-acetylcytidine, nucleotide-derived metabolites that are detectable in the blood of the former group, prime and activate the NLRC4 inflammasome, induce the production of IL-1beta, activate platelets and neutrophils and elevate blood pressure in mice.	Adenine	0-7	interleukin 1 beta	Mus musculus	184-192
28092664-4	2017	Adenine and N4-acetylcytidine, nucleotide-derived metabolites that are detectable in the blood of the former group, prime and activate the NLRC4 inflammasome, induce the production of IL-1beta, activate platelets and neutrophils and elevate blood pressure in mice.	N-acetylcytidine	12-29	interleukin 1 beta	Mus musculus	184-192
27807897-5	2017	In cultured macrophages (RAW 264.7 cells), the application of polysaccharide-enriched extract of DBT significantly increased the expressions of mRNA and protein levels of interleukin-1beta, interleukin-6 and tumor necrosis factor.	Polysaccharides	62-76	interleukin 1 beta	Mus musculus	171-188
28017641-7	2017	Further analysis showed that WY-14643 pretreatment not only inhibited the production of pro-inflammatory cytokines induced by LPS, such as interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), but also prevented the LPS-induced enhancement of oxidative and nitrosative stress in the hippocampus and prefrontal cortex.	tryptophyltyrosine	29-31	interleukin 1 beta	Mus musculus	161-178
28017641-7	2017	Further analysis showed that WY-14643 pretreatment not only inhibited the production of pro-inflammatory cytokines induced by LPS, such as interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), but also prevented the LPS-induced enhancement of oxidative and nitrosative stress in the hippocampus and prefrontal cortex.	tryptophyltyrosine	29-31	interleukin 1 beta	Mus musculus	180-188
27900599-5	2017	Melatonin effectively suppressed the upregulation of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) at both mRNA and protein levels in Mn and/or LPS-stimulated BV2 microglia.	Melatonin	0-9	interleukin 1 beta	Mus musculus	53-70
27900599-5	2017	Melatonin effectively suppressed the upregulation of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) at both mRNA and protein levels in Mn and/or LPS-stimulated BV2 microglia.	Melatonin	0-9	interleukin 1 beta	Mus musculus	72-80
27454382-13	2017	Importantly, heme significantly reduced mortality from 40.9% to 6.3% (P &lt;0.005) and gene expression of pro-inflammatory cytokines (Ccl5, Cxcl10, IL-1b, and Ifng).	Heme	13-17	interleukin 1 beta	Mus musculus	148-153
28043040-11	2017	Pretreatment with Y-27632 markedly reduced the LPS-induced expression of interleukins 1beta and 6, and the activation of nuclear factor (NF)-kappaB.	Y 27632	18-25	interleukin 1 beta	Mus musculus	73-97
28139747-5	2017	Furthermore, we observed that roxatidine suppressed the activation of caspase-1, an IL-1beta converting enzyme, in PMACI-stimulated HMC-1 and compound 48/80-induced anaphylactic mice.	roxatidine acetate	30-40	interleukin 1 beta	Mus musculus	84-92
28139747-5	2017	Furthermore, we observed that roxatidine suppressed the activation of caspase-1, an IL-1beta converting enzyme, in PMACI-stimulated HMC-1 and compound 48/80-induced anaphylactic mice.	pmaci	115-120	interleukin 1 beta	Mus musculus	84-92
28139747-3	2017	Roxatidine suppressed the mRNA and protein expression of inflammatory cytokines such as TNF-alpha, IL-6, and IL-1beta in PMACI-stimulated HMC-1 and compound 48/80-induced anaphylactic mice.	roxatidine acetate	0-10	interleukin 1 beta	Mus musculus	109-117
27393133-6	2017	Bilirubin supplementation of islet media also decreased the release of DAMPs (HMGB1), inflammatory cytokines (IL-1beta and IL-6), and chemokines (MCP-1).	Bilirubin	0-9	interleukin 1 beta	Mus musculus	110-118
28210097-7	2017	RESULTS: Data showed that high glucose increased the TNF-alpha and IL-1beta levels in the RECs, which were reduced cells treated with the Epac1 agonist.	Glucose	31-38	interleukin 1 beta	Mus musculus	67-75
28117761-6	2017	A mouse in vivo study of LPS-stimulated lung inflammation showed that phloretin effectively suppressed the levels of TNF-alpha, IL-1beta, and IL-6 in lung tissue with low cytotoxicity.	Phloretin	70-79	interleukin 1 beta	Mus musculus	128-136
27932245-5	2017	Mechanistic analyses further revealed that IL-1beta-induced activation of the NF-kappaB pathway is suppressed upon TREM-1 knockdown, similar to the effect of pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kappaB.	pyrrolidine dithiocarbamic acid	158-185	interleukin 1 beta	Mus musculus	43-51
27913620-6	2017	Importantly, treatment of cells or mice with the specific NLRP3 inhibitor MCC950 significantly reduces IL-1beta maturation, lung cellular recruitment, and cytokine production.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	74-80	interleukin 1 beta	Mus musculus	103-111
28114268-11	2017	Furthermore, miR-128 overexpression obviously decreased the concentration of TNF-alpha, IL-1beta, and IL-6.	mir-128	13-20	interleukin 1 beta	Mus musculus	88-96
27448962-9	2017	L2-IL-1beta mice were treated with a CCK2R antagonist YF476 as a potential chemopreventive drug.	YF 476	54-59	interleukin 1 beta	Mus musculus	3-11
27989509-8	2017	The effects on the mRNA expression of nitric oxide synthase (iNOS), TNF-alpha and IL-1beta of strictosamide were further investigated by RT-qPCR.	strictosamide	94-107	interleukin 1 beta	Mus musculus	82-90
27989509-10	2017	RESULTS: Strictosamide potently suppressed the productions of NO, TNF-alpha and IL-1beta in LPS-induced RAW 264.7 macrophages, and it dose-dependently alleviated the LPS-simulated protein level of iNOS as well as the mRNA expressions of iNOS, TNF-alpha and IL-1beta.	strictosamide	9-22	interleukin 1 beta	Mus musculus	80-88
27989509-10	2017	RESULTS: Strictosamide potently suppressed the productions of NO, TNF-alpha and IL-1beta in LPS-induced RAW 264.7 macrophages, and it dose-dependently alleviated the LPS-simulated protein level of iNOS as well as the mRNA expressions of iNOS, TNF-alpha and IL-1beta.	strictosamide	9-22	interleukin 1 beta	Mus musculus	257-265
27989509-13	2017	CONCLUSIONS: At present study, the results indicated that the anti-inflammatory activity of strictosamide was associated with the restraint of NO, TNF-alpha and IL-1beta via negative regulation of both NF-kappaB and mitogen-activated protein kinases (MAPKs) in LPS-induced RAW 264.7 cells.	strictosamide	92-105	interleukin 1 beta	Mus musculus	161-169
27902475-8	2017	Furthermore, osthole can suppress NF-kappaB signal pathway through the inhibition of the nuclear translocation by regulating phosphorylation of IkappaBalpha and IKKbeta and hinder the production of chemoattractant (MCP-1 and IL-8) and proinflammatory cytokines (TNF-alpha, IL-1beta and IL-6).	osthol	13-20	interleukin 1 beta	Mus musculus	273-281
27980220-4	2017	Our results showed that berberine significantly increased ATP-induced inflammasome activation as reflected by enhanced pyroptosis as well as increased release of caspase-1p10 and mature interleukin-1beta (IL-1beta) in macrophages.	Berberine	24-33	interleukin 1 beta	Mus musculus	186-203
27980220-4	2017	Our results showed that berberine significantly increased ATP-induced inflammasome activation as reflected by enhanced pyroptosis as well as increased release of caspase-1p10 and mature interleukin-1beta (IL-1beta) in macrophages.	Berberine	24-33	interleukin 1 beta	Mus musculus	205-213
27980220-4	2017	Our results showed that berberine significantly increased ATP-induced inflammasome activation as reflected by enhanced pyroptosis as well as increased release of caspase-1p10 and mature interleukin-1beta (IL-1beta) in macrophages.	Adenosine Triphosphate	58-61	interleukin 1 beta	Mus musculus	205-213
27980220-6	2017	In line with increased IL-1beta release, the ability of macrophages to kill engulfed bacteria was also intensified by berberine.	Berberine	118-127	interleukin 1 beta	Mus musculus	23-31
27980220-8	2017	Moreover, berberine administration significantly improved survival of bacterial infected mice, concomitant with increased IL-1beta levels and elevated neutrophil recruitment in the peritoneal cavity.	Berberine	10-19	interleukin 1 beta	Mus musculus	122-130
28849450-4	2017	TauCl markedly inhibited interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) production.	N-chlorotaurine	0-5	interleukin 1 beta	Mus musculus	47-64
28849450-4	2017	TauCl markedly inhibited interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) production.	N-chlorotaurine	0-5	interleukin 1 beta	Mus musculus	66-74
28867726-8	2017	The elevated concentrations of interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and IL-6, and the activation of nuclear factor-kappaB (NF-kappaB) p65 by ethanol stimulation was also reduced by acetate.	Acetates	202-209	interleukin 1 beta	Mus musculus	31-53
27615440-11	2017	(4) In primary myometrial smooth muscle cell and ex vivo uteri from wild-type mice, lactate decreased interleukin-1beta-induced transcription of key proinflammatory Il1b, Il6, Ccl2, and Pghs2; suppressive effects of lactate were not observed in cells and tissues from GPR81-/- mice.	Lactic Acid	84-91	interleukin 1 beta	Mus musculus	102-119
27615440-11	2017	(4) In primary myometrial smooth muscle cell and ex vivo uteri from wild-type mice, lactate decreased interleukin-1beta-induced transcription of key proinflammatory Il1b, Il6, Ccl2, and Pghs2; suppressive effects of lactate were not observed in cells and tissues from GPR81-/- mice.	Lactic Acid	84-91	interleukin 1 beta	Mus musculus	165-169
27615440-11	2017	(4) In primary myometrial smooth muscle cell and ex vivo uteri from wild-type mice, lactate decreased interleukin-1beta-induced transcription of key proinflammatory Il1b, Il6, Ccl2, and Pghs2; suppressive effects of lactate were not observed in cells and tissues from GPR81-/- mice.	Lactic Acid	216-223	interleukin 1 beta	Mus musculus	102-119
27903426-4	2017	Our results indicated that treatment with BI markedly decreased the levels of interleukin-6 (IL-6), IL-1beta and tumor necrosis factor-alpha (TNF-alpha) in vivo.	bilobalide	42-44	interleukin 1 beta	Mus musculus	100-108
28194406-7	2017	Additionally, curcumin treatment was associated with significant reductions in mature interleukin-1beta, cleaved caspase-1, and NLRP3 protein levels in the renal cortices of db/db mice as well as in HK-2 cells exposed to high glucose concentration.	Curcumin	14-22	interleukin 1 beta	Mus musculus	86-103
28769008-5	2017	CRS exposure caused depressive-like behaviors in mice, which was associated with increased pre-inflammatory cytokines (interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and IL-6) levels, reactive microglia numbers and up-regulated regulatory molecules such as TLR4/p38 and P2X7 receptor in hippocampus.	3-cresol	0-3	interleukin 1 beta	Mus musculus	119-141
28810254-8	2017	PD98059, which inhibits the ERK upstream activators MAPK kinase (MKK) 1 and MKK2, reduced the effect promoted by insulin in BMDM stimulated by LPS In tissue-specific macrophages, insulin reduced LPS-induced TNF-alpha, IL-6 and IL-1beta secretion in alveolar and peritoneal macrophages.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	interleukin 1 beta	Mus musculus	227-235
27864936-5	2017	KEY RESULTS: Treatment of differentiated U937 macrophages with compound 5, RB-020 or sphingosine (but not ROMe) enhanced IL-1beta release.	RB-020	75-81	interleukin 1 beta	Mus musculus	121-129
27864936-5	2017	KEY RESULTS: Treatment of differentiated U937 macrophages with compound 5, RB-020 or sphingosine (but not ROMe) enhanced IL-1beta release.	Sphingosine	85-96	interleukin 1 beta	Mus musculus	121-129
28142150-5	2017	RESULTS: Induction of diabetes by streptozotocin was associated with reduction of body weight and insulin level, increase in glucose level and pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha), and reduction in IL-2 and IL-4 levels.	Streptozocin	34-48	interleukin 1 beta	Mus musculus	171-179
27816554-3	2017	KHG26693 significantly attenuated Abeta-induced TNF-alpha and IL-1beta enhancements.	N-adamantyl-4-methylthiazol-2-amine	0-8	interleukin 1 beta	Mus musculus	62-70
27816554-3	2017	KHG26693 significantly attenuated Abeta-induced TNF-alpha and IL-1beta enhancements.	UNII-042A8N37WH	34-39	interleukin 1 beta	Mus musculus	62-70
28490015-8	2017	SDS treatment inhibited the activation of NLRP3 inflammasome and subsequent caspase-1 cleavage as well as interleukin (IL)-1beta secretion both in vivo and in vitro.	rhodioloside	0-3	interleukin 1 beta	Mus musculus	106-128
28817808-13	2017	In addition, fenofibrate inhibited IL-1beta expression caused by combination use of high glucose and lipopolysaccharide.	Fenofibrate	13-24	interleukin 1 beta	Mus musculus	35-43
28817808-13	2017	In addition, fenofibrate inhibited IL-1beta expression caused by combination use of high glucose and lipopolysaccharide.	Glucose	89-96	interleukin 1 beta	Mus musculus	35-43
28337225-7	2017	In a mouse model of PM2.5-induced inflammation established with intranasal instillation of PM2.5 suspension, BFHX significantly reduced pathological response and inflammatory mediators including IL-4, IL-6, IL-10, IL-8, TNF-alpha, and IL-1beta.	bfhx	109-113	interleukin 1 beta	Mus musculus	235-243
29130962-6	2017	RESULTS: TMAO treatment significantly increased the colocalization of NLRP3 with Asc or NLRP3 with caspase-1, caspase-1 activity, IL-1beta production, cell permeability in carotid artery endothelial cells (CAECs) compared to control cells.	trimethyloxamine	9-13	interleukin 1 beta	Mus musculus	130-138
29130962-10	2017	In animal experiments, direct infusion of TMAO in mice with partially ligated carotid artery were found to have increased NLRP3 inflammasome formation and IL-1beta production in the intima of wild type mice.	trimethyloxamine	42-46	interleukin 1 beta	Mus musculus	155-163
27401064-9	2017	Fasudil intervention also inhibited TLR-2/4, p-NF-kappaB/p65, MyD88, interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha for TLRs-NF-kappaB-MyD88 inflammatory cytokine axis and the induction of interleukin-10.	fasudil	0-7	interleukin 1 beta	Mus musculus	69-86
28246539-7	2017	The expression levels of inflammatory cytokines TNF-a, IL-1beta, and IL-6 were decreased after oral administration of SLE, probably because lignans inhibited the NF-kappaB activity.	Lignans	140-147	interleukin 1 beta	Mus musculus	55-63
29234401-5	2017	While LPS potently induced the production and expression upregulation of proinflammatory mediators, including NO, iNOS, COX-2, IL-1beta, and TNF-alpha, TCA pretreatment significantly inhibited LPS-induced production of NO and expression of iNOS, COX-2, and IL-1beta and recovered the morphological changes in BV2 cells.	cinnamaldehyde	152-155	interleukin 1 beta	Mus musculus	127-135
28676833-9	2017	Andrographolide dose-dependently inhibited the release and mRNA expression of TNF-alpha, IL-6, and IL-1beta in LPS-stimulated RAW264.7 cells.	andrographolide	0-15	interleukin 1 beta	Mus musculus	99-107
29234401-5	2017	While LPS potently induced the production and expression upregulation of proinflammatory mediators, including NO, iNOS, COX-2, IL-1beta, and TNF-alpha, TCA pretreatment significantly inhibited LPS-induced production of NO and expression of iNOS, COX-2, and IL-1beta and recovered the morphological changes in BV2 cells.	cinnamaldehyde	152-155	interleukin 1 beta	Mus musculus	257-265
27875748-4	2017	The results showed that piperine significantly inhibited LPS-induced TNF-alpha, IL-6, IL-1beta, and PGE2 production in BV2 cells.	piperine	24-32	interleukin 1 beta	Mus musculus	86-94
27766379-15	2017	They increased the cellular concentration of cAMP and attenuated the production of inflammatory cytokines such as TNFalpha and IL-1beta.	Cyclic AMP	45-49	interleukin 1 beta	Mus musculus	127-135
29147666-9	2017	In conclusion, 6-OHDA delays reepithelialization during wound healing in diabetic mice by decreasing EGF, but increases wound contraction by reducing IL-1beta levels and the number of MCs.	Oxidopamine	15-21	interleukin 1 beta	Mus musculus	150-158
28133531-10	2017	CONCLUSION: Coumarin and ICE possess anti-inflammatory properties through inhibition of PGE2 and NO along with pro-inflammatory cytokines TNF-alpha, IL-6, IL-1beta production.	coumarin	12-20	interleukin 1 beta	Mus musculus	155-163
28133531-10	2017	CONCLUSION: Coumarin and ICE possess anti-inflammatory properties through inhibition of PGE2 and NO along with pro-inflammatory cytokines TNF-alpha, IL-6, IL-1beta production.	Water	25-28	interleukin 1 beta	Mus musculus	155-163
28880739-7	2017	The methionine-supplemented diet increased oxidative stress by lowering the GSH/GSSG ratio in heart tissues and decreased expression of the genes Apob, Ctgf, Serpinb2, Spp1, Il1b, and Sell, but elevated expression of Thbs4, Tgfb2, Ccr1, and Vegfa.	Methionine	4-14	interleukin 1 beta	Mus musculus	174-178
27422938-8	2017	Seabuckthorn oil downregulated the mRNA level of inflammatory factors, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and IL-8.	seabuckthorn oil	0-16	interleukin 1 beta	Mus musculus	110-132
27256568-4	2017	In this study, we investigated whether oxidized phosphatidylcholine induces the activation of NLRP3 inflammasome in macrophages, leading to the secretion of IL-1beta.	Phosphatidylcholines	48-67	interleukin 1 beta	Mus musculus	157-165
27256568-9	2017	Our results demonstrate that endogenously produced oxidized phosphatidylcholines such as POVPC induce the activation of NLRP3 inflammasome, leading to the production of IL-1beta in macrophages.	Phosphatidylcholines	60-80	interleukin 1 beta	Mus musculus	169-177
27754929-5	2017	TNBS-induced upregulation of inflammatory cytokines (tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta), chemokines (CXCL1 and CXLC2), and inducible nitric oxide synthase (iNOS) was also significantly less in NOX1KO than in WT mice (the inhibitions were 100.8%, 89.0%, 63.5%, 96.7%, and 97.1%, respectively).	Trinitrobenzenesulfonic Acid	0-4	interleukin 1 beta	Mus musculus	91-113
28250578-7	2017	Levels of serum IL-1beta and leptin were decreased by resveratrol treatment and positively correlated with Mankin scores.	Resveratrol	54-65	interleukin 1 beta	Mus musculus	16-24
28066148-1	2017	The present study aimed to show that pro-inflammatory cytokines [tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and interleukin (IL)-1beta] synergistically induce the production of nitric oxide (NO) production in mouse mesangial cells, which play an important role in inflammatory glomerular injury.	Nitric Oxide	193-205	interleukin 1 beta	Mus musculus	128-150
28066148-3	2017	Silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), attenuates cytokine mixture (TNF-alpha, IFN-gamma, and IL-1beta)-induced NO production.	Silymarin	0-9	interleukin 1 beta	Mus musculus	138-146
28072729-0	2017	Hypertonic saline protects brain endothelial cells against hypoxia correlated to the levels of epidermal growth factor receptor and interleukin-1beta.	hypertonic	0-10	interleukin 1 beta	Mus musculus	132-149
28072729-0	2017	Hypertonic saline protects brain endothelial cells against hypoxia correlated to the levels of epidermal growth factor receptor and interleukin-1beta.	Sodium Chloride	11-17	interleukin 1 beta	Mus musculus	132-149
28373747-4	2017	Andrographolide eliminated intracellular Abeta42 in BV-2 cells and decreased the production of interleukin (IL)-6, IL-1beta, prostaglandin (PG)E2, and nitric oxide (NO) because of artificial phagocytic Abeta42.	andrographolide	0-15	interleukin 1 beta	Mus musculus	115-123
28072729-9	2017	The qPCR and western blot analyses further confirmed that the levels of EGFR/phosphorylated epidermal growth factor receptor and IL-1beta were enhanced after OGD-induced injury, but attenuated after treatment with 40 mmol/L of NaCl HS.	nacl hs	227-234	interleukin 1 beta	Mus musculus	129-137
28182085-12	2017	On the contrary, the expression of procaspase-1 and pro-IL-1beta protein was restrained by high glucose and enhanced by maresin 1 in a dose-dependent manner (P &lt; 0.05).	Glucose	96-103	interleukin 1 beta	Mus musculus	56-64
29038619-6	2017	Among various cytokines, levels of IL-1alpha, IL-1beta, IL-4, IL-6, and IL-13 were significantly elevated in nose or lung tissue from the CIH group.	cih	138-141	interleukin 1 beta	Mus musculus	46-54
28321151-4	2017	CQ attenuated NF-kappaB and MAPK activation and prohibited expression of IL-1beta, IL-18, and Nlrp3 in LPS treated murine bone marrow-derived macrophages (BMDMs), demonstrating its inhibitory effect on the priming signal of NLRP3 activation.	Chloroquine	0-2	interleukin 1 beta	Mus musculus	73-81
28321151-6	2017	In a murine endotoxic shock model, CQ effectively improved survival and markedly reduced IL-1beta and IL-18 production in serum, peritoneal fluid, and lung tissues.	Chloroquine	35-37	interleukin 1 beta	Mus musculus	89-97
28348460-8	2017	Epac1 effectively reduced high glucose-induced increases in TLR4, HMGB1, cleaved caspase-1, and IL-1beta in REC.	Glucose	31-38	interleukin 1 beta	Mus musculus	96-104
29249872-2	2017	Proinflammatory cytokines such as IL-1beta, IL-6, TNF-alpha, IFN-gamma, IL-12, IL-17, and NO can be released by CD4 and CD8+ lymphocytes as well as by classically activated macrophages (CAMphis), which are important in the development of T1D.	camphis	186-193	interleukin 1 beta	Mus musculus	34-42
28326946-6	2017	In addition, dendrimer-conjugated triamcinolone acetonide administration (intrathecal) inhibited peripheral nerve injury-induced spinal cord microglial activation and the expression of pain-related genes in the spinal cord, including Nox2, IL-1beta, TNF-alpha, and IL-6.	Triamcinolone Acetonide	34-57	interleukin 1 beta	Mus musculus	240-248
29358851-8	2017	Anti-IL-22 nAb significantly alleviated the severity of hypertrophy, prevented systolic and diastolic abnormalities, reduced cardiac fibrosis, STAT3 and ERK phosphorylation, and downregulated the mRNA expression of IL-17, IL-6, IL-1beta, IFN-gamma, and TNF-alpha.	nab	11-14	interleukin 1 beta	Mus musculus	228-236
28381108-5	2017	Zymosan-induced inflammatory markers such as COX-2, TNFalpha, IL-1beta, and c-fos in the spinal cord were not altered by caloric restriction.	Zymosan	0-7	interleukin 1 beta	Mus musculus	62-70
28024724-10	2017	Rosiglitazone significantly inhibited radiation-induced tnfalpha, Il-6 and Il-1beta gene expression.	Rosiglitazone	0-13	interleukin 1 beta	Mus musculus	75-83
27529351-10	2017	Sod1 and Il1b were significantly differentially expressed when comparing reoxygenation using 60% O2 with air.	Oxygen	97-99	interleukin 1 beta	Mus musculus	9-13
29131114-6	2017	RESULTS: RA attenuated the expression of the M1 marker iNOS and the levels of proinflammatory factors, including TNF-alpha, IL-1beta, and IL-6; it increased the expression of the M2 marker Arg-1, and inhibited, at least in part, ROS generation and loss of mitochondrial outer membrane permeabilization through the inhibition of cleaved caspase-3 activation.	rosmarinic acid	9-11	interleukin 1 beta	Mus musculus	124-132
28243356-6	2017	Isoorientin treated RAW 264.7 cells and animals showed reduced expression of inflammatory proteins like COX-2, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), 5-lipoxygenase (5-LOX), and interleukin 1-beta (IL-1-beta) both in vitro and in vivo.	homoorientin	0-11	interleukin 1 beta	Mus musculus	202-220
28243356-6	2017	Isoorientin treated RAW 264.7 cells and animals showed reduced expression of inflammatory proteins like COX-2, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), 5-lipoxygenase (5-LOX), and interleukin 1-beta (IL-1-beta) both in vitro and in vivo.	homoorientin	0-11	interleukin 1 beta	Mus musculus	222-231
28819543-4	2017	Diosmin treatment ameliorated the MTX-induced elevation of serum alkaline phosphatase, aminotransferases, urea, creatinine, lactate dehydrogenase, and creatine kinases as well as plasma proinflammatory cytokines (interleukin-1-beta, interleukin-6, and tumor necrosis factor-alpha).	Diosmin	0-7	interleukin 1 beta	Mus musculus	213-231
28951767-6	2017	Baicalin attenuated ethanol-induced proinflammatory molecules such as TNF-alpha, IL-1beta, MIP-2, and MCP-1 and reversed redox-sensitive transcription factor NF-kappaB activation.	baicalin	0-8	interleukin 1 beta	Mus musculus	81-89
28951767-6	2017	Baicalin attenuated ethanol-induced proinflammatory molecules such as TNF-alpha, IL-1beta, MIP-2, and MCP-1 and reversed redox-sensitive transcription factor NF-kappaB activation.	Ethanol	20-27	interleukin 1 beta	Mus musculus	81-89
28912935-10	2017	In addition to that, baicalin attenuated microglial cell secretion of IL-1beta and IL-6 induced by lipopolysaccharide (100 ng/ml) dose dependently.	baicalin	21-29	interleukin 1 beta	Mus musculus	70-78
27633406-4	2016	The antinociceptive and anti-inflammatory activities of the SEPAc were evaluated after oral administration on the acute nocifensive behavior of mice induced by formalin, prostaglandin E2 (PGE2) and proinflammatory cytokines (interleukin-1beta (IL-1beta)) and tumor necrosis factor-alpha (TNF-alpha) in mice.	sepac	60-65	interleukin 1 beta	Mus musculus	225-242
28096658-14	2017	In mice with carrageenan-induced peritonitis, oral pretreatment with girinimbine helped limit total leukocyte migration (mainly of neutrophils), and reduced pro-inflammatory cytokine levels (interleukin-1beta and tumor necrosis factor-alpha) in the peritoneal fluid.	girinimbine	69-80	interleukin 1 beta	Mus musculus	191-240
28646838-7	2017	Results: Average serum levels of IL-1beta were significantly higher (p&lt;0.05) in the DDT treated mice compared to controls.	DDT	87-90	interleukin 1 beta	Mus musculus	33-41
27633406-4	2016	The antinociceptive and anti-inflammatory activities of the SEPAc were evaluated after oral administration on the acute nocifensive behavior of mice induced by formalin, prostaglandin E2 (PGE2) and proinflammatory cytokines (interleukin-1beta (IL-1beta)) and tumor necrosis factor-alpha (TNF-alpha) in mice.	sepac	60-65	interleukin 1 beta	Mus musculus	244-252
27633406-6	2016	The SEPAc exhibited antinociceptive and anti-inflammatory activities in both formalin phases, with significant inhibition of the paw edema formation and significant reduction of the nocifensive response induced by an intraplantar injection of PGE2 and intrathecal injection of interleukin-1beta.	sepac	4-9	interleukin 1 beta	Mus musculus	277-294
28004759-9	2016	LR12 also reduced the expression of NLRP3 and caspase-1 p10 protein, and secretion of the IL-1beta, inhibited activation of the NLRP3 inflammasome by decreasing ROS.	ros	161-164	interleukin 1 beta	Mus musculus	90-98
27838229-10	2016	Carvacrol was found to exert an anti-inflammatory action against CPT-11-induced intestinal mucositis through strong interactions with TRPA1 receptors; reduction in the production or release or both of pro-inflammatory cytokines (TNF-alpha, IL-1beta, and KC); and decrease in other indicators of inflammation (MPO, NF-kappaB, COX-2) and oxidative stress (GSH, MDA, and NOx levels).	carvacrol	0-9	interleukin 1 beta	Mus musculus	240-248
27838229-10	2016	Carvacrol was found to exert an anti-inflammatory action against CPT-11-induced intestinal mucositis through strong interactions with TRPA1 receptors; reduction in the production or release or both of pro-inflammatory cytokines (TNF-alpha, IL-1beta, and KC); and decrease in other indicators of inflammation (MPO, NF-kappaB, COX-2) and oxidative stress (GSH, MDA, and NOx levels).	Irinotecan	65-71	interleukin 1 beta	Mus musculus	240-248
28078039-10	2016	The expressions of caspase-1, NLRP3, IL-1beta, and IL-18 in LPS+ATP group were significantly higher than the control group by Western blot and ELISA.	Adenosine Triphosphate	64-67	interleukin 1 beta	Mus musculus	37-45
28002460-9	2016	In addition, metformin supplementation in IL10KO mice suppressed macrophage pro-inflammatory activity as indicated by reduced M1 macrophage abundance and decreased pro-inflammatory cytokine IL-1beta, TNF-alpha and IFN-gamma expressions.	Metformin	13-22	interleukin 1 beta	Mus musculus	190-198
27924062-4	2016	In this study, we for the first time showed that chenodeoxycholic acid (CDCA), the major hydrophobic primary bile acid involved in cholestatic liver injury, could dose-dependently induce NLRP3 inflammasome activation and secretion of pro-inflammatory cytokine-IL-1beta in macrophages by promoting ROS production and K+ efflux.	Chenodeoxycholic Acid	49-70	interleukin 1 beta	Mus musculus	260-268
27924062-4	2016	In this study, we for the first time showed that chenodeoxycholic acid (CDCA), the major hydrophobic primary bile acid involved in cholestatic liver injury, could dose-dependently induce NLRP3 inflammasome activation and secretion of pro-inflammatory cytokine-IL-1beta in macrophages by promoting ROS production and K+ efflux.	Chenodeoxycholic Acid	72-76	interleukin 1 beta	Mus musculus	260-268
27983945-9	2016	Memantine significantly attenuated the body weight loss, colon weight, the plasma levels of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and colon level of tumor necrosis factor-alpha (TNF-alpha) and myeloperoxidase (MPO); as well as macroscopic and microscopic signs of colitis.	Memantine	0-9	interleukin 1 beta	Mus musculus	92-109
27983945-9	2016	Memantine significantly attenuated the body weight loss, colon weight, the plasma levels of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and colon level of tumor necrosis factor-alpha (TNF-alpha) and myeloperoxidase (MPO); as well as macroscopic and microscopic signs of colitis.	Memantine	0-9	interleukin 1 beta	Mus musculus	111-119
28018360-7	2016	Importantly, metformin administration increased the mortality of mice with bacterial sepsis, which was likely because metformin treatment enhanced the systemic inflammasome activation as indicated by elevated serum and hepatic IL-1beta levels.	Metformin	118-127	interleukin 1 beta	Mus musculus	227-235
27966619-6	2016	Oxazolone treatment stimulated maturation of pro-caspase-1 and pro-IL-1beta, while it reduced IL-18 expression.	Oxazolone	0-9	interleukin 1 beta	Mus musculus	67-75
27966619-9	2016	Compared to wild-type mice, NLRP3-/- mice exhibited higher sensitivity to oxazolone treatment with enhancement of Th2 cytokine expression and reduction of mature IL-1beta and IL-18 production; this phenotype was rescued by exogenous IL-1beta or IL-18.	Oxazolone	74-83	interleukin 1 beta	Mus musculus	233-241
28018360-5	2016	Our results showed that AMPK signaling was activated in murine macrophages upon ATP treatment, which was accompanied by inflammasome activation and pyroptosis as evidenced by rapid cell membrane rupture as well as mature interleukin (IL)-1beta and active caspase-1p10 release.	Adenosine Triphosphate	80-83	interleukin 1 beta	Mus musculus	221-243
27803035-7	2016	In vitro, aldosterone stimulated NLRP3-dependent interleukin-1beta secretion by bone marrow-derived macrophages by activating nuclear factor-kappaB signaling and reactive oxygen species generation.	Aldosterone	10-21	interleukin 1 beta	Mus musculus	49-66
28018360-7	2016	Importantly, metformin administration increased the mortality of mice with bacterial sepsis, which was likely because metformin treatment enhanced the systemic inflammasome activation as indicated by elevated serum and hepatic IL-1beta levels.	Metformin	13-22	interleukin 1 beta	Mus musculus	227-235
27934918-4	2016	In primary mouse macrophages, caffeic acid phenethyl ester(CAPE) blocked caspase-1 activation and IL-1beta production induced by MSU crystals, showing that CAPE suppresses NLRP3 inflammasome activation.	caffeic acid phenethyl ester	30-58	interleukin 1 beta	Mus musculus	98-106
27803035-5	2016	Long-term infusion of aldosterone in mice resulted in elevation of plasma interleukin-1beta levels and vascular abnormalities.	Aldosterone	22-33	interleukin 1 beta	Mus musculus	74-91
27930719-11	2016	Serum levels of prostaglandin E2 (PGE2), TNF-alpha, and IL-1beta were also down-regulated by eBV.	(2S)-2-amino-1-[(3aR,6aS)-5-[(5-chloro-1H-indol-3-yl)methyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-3-(1H-indol-3-yl)propan-1-one	93-96	interleukin 1 beta	Mus musculus	56-64
27803035-7	2016	In vitro, aldosterone stimulated NLRP3-dependent interleukin-1beta secretion by bone marrow-derived macrophages by activating nuclear factor-kappaB signaling and reactive oxygen species generation.	Reactive Oxygen Species	162-185	interleukin 1 beta	Mus musculus	49-66
27793052-4	2016	Mechanically, Andrographolide markedly hampered the activation of nuclear factor-kappaB (NF-kappaB) and NLRP3 inflammasome both in vivo and vitro thus decreased levels of TNF-alpha and IL-1beta.	andrographolide	14-29	interleukin 1 beta	Mus musculus	185-193
27685787-3	2016	Results of ELISA revealed that DAC and Aza significantly inhibited the production of TNF-alpha and IL-1beta and prevented LPS-induced elevation of myeloperoxidase and malondialdehyde levels in serum.	Azacitidine	39-42	interleukin 1 beta	Mus musculus	99-107
27825966-4	2016	Pretreatment with hypericin (5 muM and 15 muM) significantly suppresses oligomeric Abeta42 (oAbeta42)-induced expression of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF alpha) and inducible nitric oxide synthase (iNOS) and production of NO in microglia without cytotoxicity.	hypericin	18-27	interleukin 1 beta	Mus musculus	124-141
27636512-8	2016	In FST-induced fatigue mouse model, the mice which received the GL or LG for 21days showed significant decreases of IL-1beta, IL-6, and NO serum levels.	gl	64-66	interleukin 1 beta	Mus musculus	116-124
27562319-6	2016	RESULTS: Cm-ME downregulated the production of prostaglandin (PG)E2 and the mRNA expression of cyclooxygenase (COX)-2, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1beta in LPS-stimulated RAW264.7 cells under non-toxic concentration of Cm-ME.	cm-me	9-14	interleukin 1 beta	Mus musculus	158-180
27643555-6	2016	In addition, resveratrol reversed the LPS-mediated elevation of IL-1beta and IL-18 level in the BAL fluids.	Resveratrol	13-24	interleukin 1 beta	Mus musculus	64-72
27716530-5	2016	Furthermore, Naringin inhibited LPS-induced increase of TNF-alpha, IL-1beta and IL-6 activities to alleviate inflammatory response in heart.	naringin	13-21	interleukin 1 beta	Mus musculus	67-75
27829543-5	2016	Our results shown that PA significantly decreased the urine levels of uric acid and creatinine, serum and kidney levels of cytokines such as interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), PA also obviously attenuated the histological changes of the kidney tissues caused by CYP.	peoniflorin	23-25	interleukin 1 beta	Mus musculus	163-180
27829543-5	2016	Our results shown that PA significantly decreased the urine levels of uric acid and creatinine, serum and kidney levels of cytokines such as interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), PA also obviously attenuated the histological changes of the kidney tissues caused by CYP.	peoniflorin	23-25	interleukin 1 beta	Mus musculus	182-190
27334509-10	2016	In AOS group, titer for IL-1beta in BAL fluid was significantly lower than restraint group (P=0.049).	D-(+)-ALLOSE	3-6	interleukin 1 beta	Mus musculus	24-32
27619518-8	2016	Carvedilol treatment also significantly reduced the levels of proinflammatory cytokines tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, transforming growth factor (TGF)-beta1 and monocyte chemoattractant protein (MCP)-1 in the lung tissue.	Carvedilol	0-10	interleukin 1 beta	Mus musculus	123-145
26213241-9	2016	In addition, LPS-induced expression of proinflammatory mediators such as TNF-alpha and IL-1beta were also inhibited by 5,7-dihydroxy-8-methoxyflavone.	wogonin	119-149	interleukin 1 beta	Mus musculus	87-95
26296324-5	2016	In addition, vanillin markedly attenuated the expression levels of proinflammatory cytokines, including tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and COX2 and prevented KBrO3 -induced hepatic cell alteration and necrosis, as indicated by histopathological data.	vanillin	13-21	interleukin 1 beta	Mus musculus	133-150
27543123-4	2016	Using the inflammasome protocol, exposure of cardiomyocytes (CMs) to LPS followed by ATP or nigericin caused release of mature IL-1beta.	Adenosine Triphosphate	85-88	interleukin 1 beta	Mus musculus	127-135
28101182-6	2016	Furthermore, treatment with taraxasterol significantly suppressed tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and nuclear factor-kappaB protein expression levels compared with those in the rheumatoid arthritis model mice.	taraxasterol	28-40	interleukin 1 beta	Mus musculus	95-117
27630169-6	2016	In wild-type hepatic macrophages, deoxycholic acid induced the association of Gal3 and NLRP3 with direct activation of the inflammasome, resulting in an increase in IL-1beta.	Deoxycholic Acid	34-50	interleukin 1 beta	Mus musculus	165-173
27543123-4	2016	Using the inflammasome protocol, exposure of cardiomyocytes (CMs) to LPS followed by ATP or nigericin caused release of mature IL-1beta.	Nigericin	92-101	interleukin 1 beta	Mus musculus	127-135
27516212-6	2016	The up-regulated IgE, histamine, interleukin (IL)-1beta, and thymic stromal lymphopoietin (TSLP) levels in the serum of OVA-sensitized mice were significantly decreased by the treatment with PA.	2-(4-(2-((phenylthio)acetyl)carbonohydrazonoyl)phenoxy)acetamide	191-193	interleukin 1 beta	Mus musculus	33-55
27624059-3	2016	When N9 cell line was activated by LPS, PAE (0.6, 3, 15 muM) significantly suppressed the release of proinflammatory products, such as nitric oxide (NO), interleukin-1beta (IL-1beta), and prostaglandin E2 (PGE2), demonstrated by the ELISA assay.	paeonol	40-43	interleukin 1 beta	Mus musculus	154-171
27624059-3	2016	When N9 cell line was activated by LPS, PAE (0.6, 3, 15 muM) significantly suppressed the release of proinflammatory products, such as nitric oxide (NO), interleukin-1beta (IL-1beta), and prostaglandin E2 (PGE2), demonstrated by the ELISA assay.	paeonol	40-43	interleukin 1 beta	Mus musculus	173-181
27581278-3	2016	We observed that neougonin A reduced the production of inflammatory mediators (TNFalpha, PGE2, NO, IL-1beta, and IL-6; P &lt; 0.001) and inflammation-related proteins (iNOS and COX-2) induced by LPS in murine macrophage RAW 264.7 cells.	neougonin A	17-28	interleukin 1 beta	Mus musculus	99-107
27581278-5	2016	It was suggested that the anti-inflammatory actions of neougonin A might be due to the downregulation of TNFalpha, IL-1beta, IL-6, NO, and PGE2 via the suppression of NF-kB signal transduction pathway.	neougonin A	55-66	interleukin 1 beta	Mus musculus	115-123
27573128-5	2016	The addition of Fasudil inhibited MSC-induced inflammatory signaling TLR-4/MyD88 and inflammatory molecule IFN-gamma, IL-1beta, and TNF-alpha but did not convert M1 microglia to M2 phenotype.	fasudil	16-23	interleukin 1 beta	Mus musculus	118-126
27840892-7	2016	Compared to wild-type mice treated with DSS, HNP-1 transgenic mice treated with DSS had significantly lower clinical and histological scores, and lower colonic mRNA levels of pro-inflammatory cytokines, including interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha.	Dextran Sulfate	80-83	interleukin 1 beta	Mus musculus	213-235
26666668-12	2016	Real-time PCR and Western blotting revealed that Corilagin downregulated the expression of TNF-alpha and IL-1beta and inhibited the irradiation-induced activation of NF-kappaB pathways by upregulating p-STAT3 expression.	corilagin	49-58	interleukin 1 beta	Mus musculus	105-113
27840936-6	2016	The elevated serum levels of MDA, SOD, TNF-alpha and IL-1beta were markedly suppressed by the effective treatment of polydatin in CIA mice, compared with the CIA model group.	polydatin	117-126	interleukin 1 beta	Mus musculus	53-61
27599597-10	2016	Eucalyptol reduced cytokine levels (IL-1beta, IL-6 and KC) at 3 mg/mL and 10 mg/mL concentrations (p &lt; 0.01) compared to the CS group.	Eucalyptol	0-10	interleukin 1 beta	Mus musculus	36-44
27387273-8	2016	Examination of cytokine levels (TNF-alpha, IL-1beta and IL-6) in each group proved that silymarin treatment significantly decreased inflammation in DIO mice.	Silymarin	88-97	interleukin 1 beta	Mus musculus	43-51
27928219-7	2016	The SDS reduced the inflammatory cells in BALF, decreased the wet/dry ratio of lungs, attenuated the LPS-induced histological alterations in the lung, and inhibited the production of TNF-alpha, IL-1beta, and IL-6.	rhodioloside	4-7	interleukin 1 beta	Mus musculus	194-202
27882934-4	2016	IL-1beta causes prolongation of the action potential duration, induces a decrease in potassium current and an increase in calcium sparks in cardiomyocytes, which are changes that underlie arrhythmia propensity.	Potassium	85-94	interleukin 1 beta	Mus musculus	0-8
27965665-4	2016	Here, we, for the first time, showed that DCA dose-dependently induced NLRP3 inflammasome activation and highly pro-inflammatory cytokine-IL-1beta production in macrophages.	Deoxycholic Acid	42-45	interleukin 1 beta	Mus musculus	138-146
27965665-6	2016	Colorectal instillation of DCA significantly increased mature IL-1beta level in colonic tissue and exacerbated DSS-induced colitis, while in vivo blockage of NLRP3 inflammasome or macrophage depletion dramatically reduced the mature IL-1beta production and ameliorated the aggravated inflammatory injury imposed by DCA.	Deoxycholic Acid	27-30	interleukin 1 beta	Mus musculus	62-70
27965665-6	2016	Colorectal instillation of DCA significantly increased mature IL-1beta level in colonic tissue and exacerbated DSS-induced colitis, while in vivo blockage of NLRP3 inflammasome or macrophage depletion dramatically reduced the mature IL-1beta production and ameliorated the aggravated inflammatory injury imposed by DCA.	Deoxycholic Acid	27-30	interleukin 1 beta	Mus musculus	233-241
27882934-4	2016	IL-1beta causes prolongation of the action potential duration, induces a decrease in potassium current and an increase in calcium sparks in cardiomyocytes, which are changes that underlie arrhythmia propensity.	Calcium	122-129	interleukin 1 beta	Mus musculus	0-8
27733681-9	2016	Importantly, PL and PLP reduced IL-1beta production induced by LPS and ATP, or by LPS alone, in mice.	Adenosine Triphosphate	71-74	interleukin 1 beta	Mus musculus	32-40
27876064-11	2016	Treatment of HFD fed mice with melatonin led to a significant decrease in the expression of TNF-alpha, IL-1beta, and IL-6 measured using quantitative real-time polymerase chain reaction (qRT-PCR).	Melatonin	31-40	interleukin 1 beta	Mus musculus	103-111
27874078-6	2016	Furthermore, BCH treatment reduced the expression levels of inflammatory cytokines such as TNF-alpha and IL-1beta in HF/HFr-fed mouse liver.	bis(cyclohexylammonium)sulfate	13-16	interleukin 1 beta	Mus musculus	105-113
27895584-10	2016	In addition, iPS cell administration remarkably suppressed BLM-induced up-regulation of pulmonary inflammatory mediators, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and prostaglandin E2.	IPS	13-16	interleukin 1 beta	Mus musculus	161-183
27733681-0	2016	Vitamin B6 Prevents IL-1beta Protein Production by Inhibiting NLRP3 Inflammasome Activation.	Vitamin B 6	0-10	interleukin 1 beta	Mus musculus	20-28
27663762-10	2016	Rapamycin treatment attenuated interleukin 1beta and transforming growth factor beta induction in irradiated lungs compared with the control diet.	Sirolimus	0-9	interleukin 1 beta	Mus musculus	31-84
27895584-10	2016	In addition, iPS cell administration remarkably suppressed BLM-induced up-regulation of pulmonary inflammatory mediators, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and prostaglandin E2.	Bleomycin	59-62	interleukin 1 beta	Mus musculus	161-183
27742831-4	2016	This directly correlates with an inflammatory phenotype because glycolysis inhibition by 2-deoxyglucose abolished GM-CSF-mediated increase of TNF-alpha, IL-1beta, IL-6, and IL-12p70 synthesis upon LPS stimulation.	Deoxyglucose	89-103	interleukin 1 beta	Mus musculus	153-161
27738319-8	2016	Mice bearing ER-SQ20B xenografts had significantly lesser circulating levels of G-CSF and IL-1beta when treated with anakinra +- erlotinib compared to those treated with water or erlotinib alone.	Erlotinib Hydrochloride	129-138	interleukin 1 beta	Mus musculus	90-98
27747357-5	2016	Furthermore, oral administration of beta-glucans decreases the concentration of malondialdehyde (MDA) and myeloperoxidase (MPO) and inhibits the expression of iNOS and several inflammatory factors: TNF-alpha, IL-1beta and IL-6 as well as nitric oxide (NO) of the colonic tissues.	beta-Glucans	36-48	interleukin 1 beta	Mus musculus	209-217
27689324-5	2016	In microvascular endothelial cells (MVECs), palmitate markedly induces Nlrp3 inflammasome complex formation leading to caspase-1 activation and IL1beta production.	Palmitates	44-53	interleukin 1 beta	Mus musculus	144-151
27834881-6	2016	SDS significantly inhibited protein secretion and mRNA expression of of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha.	rhodioloside	0-3	interleukin 1 beta	Mus musculus	72-94
27834881-10	2016	Further investigation indicated that SDS markedly decreased protein level of IL-1beta in serum.	rhodioloside	37-40	interleukin 1 beta	Mus musculus	77-85
27447115-6	2016	Mechanistically, spermidine was found to specifically suppress the expression of interleukin-1beta (IL-1beta), IL-12 and CD80 while enhance the expression of arginase 1 in macrophages.	Spermidine	17-27	interleukin 1 beta	Mus musculus	81-98
27542954-12	2016	Stimulation of soluble sodium urate induced IL-1beta and Alpk1 mRNA production in mice kidney.	Uric Acid	23-35	interleukin 1 beta	Mus musculus	44-52
27680589-5	2016	Compound 4 pretreatment resulted in markedly suppression of TPA-induced IL-1beta, IL-6, TNF-alpha, and COX-2, respectively.	Tetradecanoylphorbol Acetate	60-63	interleukin 1 beta	Mus musculus	72-80
27553677-4	2016	c-Met inhibition by capmatinib reduced DEN-induced elevation of the pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-17A, IL-23(p19/40) and IFN-gamma, which correlated well with serum markers of hepatocellular injury (ALT, AST and LDH).	capmatinib	20-30	interleukin 1 beta	Mus musculus	106-114
27553677-4	2016	c-Met inhibition by capmatinib reduced DEN-induced elevation of the pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-17A, IL-23(p19/40) and IFN-gamma, which correlated well with serum markers of hepatocellular injury (ALT, AST and LDH).	Diethylnitrosamine	39-42	interleukin 1 beta	Mus musculus	106-114
27447115-6	2016	Mechanistically, spermidine was found to specifically suppress the expression of interleukin-1beta (IL-1beta), IL-12 and CD80 while enhance the expression of arginase 1 in macrophages.	Spermidine	17-27	interleukin 1 beta	Mus musculus	100-108
27562518-7	2016	OGD/R significantly decreased the cell viability and increased the release of IL-1beta, IL-6, IL-8, IL-10, TNF-alpha in BV2 microglia cells; these effects were suppressed by ginkgolide and bilobalide.	bilobalide	189-199	interleukin 1 beta	Mus musculus	78-86
27734611-8	2016	Hyperbaric oxygen therapy (HBOT) could inhibit glioma cell proliferation and inflammatory cell infiltration, and exert a sensitizing effect on ACNU therapy partially through enhancing oxygen pressure (PO2 ) in tumor tissues and lower expression levels of HIF-1alpha, TNF-alpha, IL-1beta, VEGF, MMP9, and NF-kappaB.	Oxygen	11-17	interleukin 1 beta	Mus musculus	278-286
27734611-8	2016	Hyperbaric oxygen therapy (HBOT) could inhibit glioma cell proliferation and inflammatory cell infiltration, and exert a sensitizing effect on ACNU therapy partially through enhancing oxygen pressure (PO2 ) in tumor tissues and lower expression levels of HIF-1alpha, TNF-alpha, IL-1beta, VEGF, MMP9, and NF-kappaB.	Nimustine	143-147	interleukin 1 beta	Mus musculus	278-286
27543936-6	2016	Our results demonstrate that Z-590 significantly decreases the production of nitric oxide (NO), tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, IL-1beta, cyclooxygenase (COX-2), inducible nitric oxide synthase (iNOS) as well as reactive oxygen species (ROS) involved in inhibiting MAKPs signalling pathway in LPS-stimulated microglia cells.	z-590	29-34	interleukin 1 beta	Mus musculus	158-166
27549113-5	2016	A single GLA exposure (1 mg/kg) induced seizures and inflammatory cell recruitment in the broncho-alveolar space, and increased myeloperoxidase (MPO), inducible NO synthase (iNOS), interstitial inflammation and disruption of alveolar septae within 6-24 h. Interleukin 1beta (IL-1beta) was increased and lung inflammation depended on IL-1 receptor 1 (IL-1R1).	phosphinothricin	9-12	interleukin 1 beta	Mus musculus	256-273
27549113-5	2016	A single GLA exposure (1 mg/kg) induced seizures and inflammatory cell recruitment in the broncho-alveolar space, and increased myeloperoxidase (MPO), inducible NO synthase (iNOS), interstitial inflammation and disruption of alveolar septae within 6-24 h. Interleukin 1beta (IL-1beta) was increased and lung inflammation depended on IL-1 receptor 1 (IL-1R1).	phosphinothricin	9-12	interleukin 1 beta	Mus musculus	275-283
27439540-6	2016	Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, and IL-4 through blockade of caspase-1/nuclear factor-kappaB pathway in stimulated splenocytes.	Lysine	18-21	interleukin 1 beta	Mus musculus	118-126
27307019-6	2016	In parallel, there was a significant upregulation of procollagen alpha1(I), alpha-SMA and TGF-beta transcripts in HOCl animals, whereas IL-1beta and MMP-13 mRNA levels were significantly increased in bleomycin-treated mice.	Bleomycin	200-209	interleukin 1 beta	Mus musculus	136-144
27439540-6	2016	Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, and IL-4 through blockade of caspase-1/nuclear factor-kappaB pathway in stimulated splenocytes.	Leucine	27-30	interleukin 1 beta	Mus musculus	118-126
27439540-6	2016	Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta, and IL-4 through blockade of caspase-1/nuclear factor-kappaB pathway in stimulated splenocytes.	farnesyl pyrophosphate	13-16	interleukin 1 beta	Mus musculus	118-126
27847478-10	2016	Compared with the untreated chronic viral myocarditis mice, ivabradine significantly increased the survival rate, attenuated the myocardial lesions and fibrosis, improved the impairment of the left ventricular function, diminished the heart dimension, decreased the production of collagen I and collagen III, reduced the expression of the proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6, and lowered the production of phospho-p38 MAPK.	Ivabradine	60-70	interleukin 1 beta	Mus musculus	376-384
27306439-0	2016	Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1beta/IL-1R1/MyD88/NF-kappaB pathway.	5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone	0-14	interleukin 1 beta	Mus musculus	118-126
27584055-5	2016	DTMF also decreased LPS-induced inducible nitric oxide synthase (iNOS), cyclooxygenase (COX-2) expression but attenuated LPS-induced nitrite (NO) and prostaglandin E2 (PGE2), as well as TNF-alpha and IL-1beta production.	ayanin	0-4	interleukin 1 beta	Mus musculus	200-208
26923552-1	2016	Our previous studies have shown that Dexamethasone (Dex) reduced the expression of matrix-metalloproteinases (MMPs -1,-3,-9,-13), IL-1beta and IL-6, while it significantly increased MMP-8 mRNA transcripts in a concomitant dry eye and corneal alkali burn murine model (CM).	Dexamethasone	37-50	interleukin 1 beta	Mus musculus	130-138
26923552-1	2016	Our previous studies have shown that Dexamethasone (Dex) reduced the expression of matrix-metalloproteinases (MMPs -1,-3,-9,-13), IL-1beta and IL-6, while it significantly increased MMP-8 mRNA transcripts in a concomitant dry eye and corneal alkali burn murine model (CM).	Dexamethasone	37-40	interleukin 1 beta	Mus musculus	130-138
27764742-5	2016	Further, the effects of hyperin on cisplatin-induced TNF-alpha, IL-1beta and IL-6 were detected by ELISA.	Cisplatin	35-44	interleukin 1 beta	Mus musculus	64-72
27764742-8	2016	The levels of BUN, creatinine, ROS, MDA, TNF-alpha, IL-1beta and IL-6 induced by cisplatin were also inhibited by hyperin.	Cisplatin	81-90	interleukin 1 beta	Mus musculus	52-60
27764743-6	2016	In vivo, the results showed that oroxylin A dose-dependently attenuated CS-induced lung histopathologic changes, expression of cytokines TNF-alpha, IL-1beta, and MCP-1, and levels of oxidative biomarkers 3-nitrotyrosine and 8-isoprostane.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	33-41	interleukin 1 beta	Mus musculus	148-156
27306439-15	2016	This study demonstrated that FD, attenuates BLM-induced pulmonary inflammation and fibrosis in mice via inhibiting the activation of NALP3 inflammasome and the IL-1beta/IL-1R1/MyD88/ NF-kappaB pathway.	Bleomycin	44-47	interleukin 1 beta	Mus musculus	160-168
27306439-3	2016	In this study, we explored whether a potential anti-fibrotic agent fluorofenidone (FD) exerts its anti-inflammatory and anti-fibrotic effects through suppressing activation of NACHT, LRR and PYD domains-containing protein 3 (NALP3) inflammasome and the IL-1beta/IL-1R1/MyD88/NF-kappaB pathway in vivo and in vitro.	5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone	67-81	interleukin 1 beta	Mus musculus	253-261
27845863-10	2016	Furthermore, treatment with ESS significantly reduced levels of tumor necrosis factor-alpha and interleukin-1beta stimulated with LPS in mouse hippocampus.	ESS	28-31	interleukin 1 beta	Mus musculus	96-113
27602597-10	2016	Increases in IFNgamma and TNFalpha were seen in the serum of mice exposed to TBT for less than 24 h. Levels of IL1beta, IL-12 betap40, IL-5 and IL-15 were also modulated in mouse serum, depending on the specific experiment and exposure level.	tributyltin	77-80	interleukin 1 beta	Mus musculus	111-118
27535376-9	2016	In addition, resveratrol suppressed the EAE-induced overexpression of proinflammatory transcripts iNOS and IL-1beta and upregulated the expression of anti-inflammatory transcripts arginase 1 and IL-10 cytokine in the brain.	Resveratrol	13-24	interleukin 1 beta	Mus musculus	107-115
27522965-7	2016	The immunoblotting and morphological results showed that anthocyanins treatment significantly reduced LPS-induced-ROS-mediated neuroinflammation through inhibition of various inflammatory mediators, such as IL-1beta, TNF-alpha and the transcription factor NF-kB.	Anthocyanins	57-69	interleukin 1 beta	Mus musculus	207-215
27500965-3	2016	We further examined whether the demethylating agent 5-azacytidine induced IL-1beta expression in BV2 and primary microglia similar to microglia from aged mice.	Azacitidine	52-65	interleukin 1 beta	Mus musculus	74-82
27500965-5	2016	Last, 5-azacytidine increased IL-1beta gene expression and decreased DNA methylation of BV2 and primary microglial cells similar to microglia from aged mice.	Azacitidine	6-19	interleukin 1 beta	Mus musculus	30-38
27401255-8	2016	PD98059, an inhibitor of ERK kinase, attenuated LPS-induced nuclear translocation of NF-kappaB and induction of mRNAs for iNOS, IL-1beta and IL-6.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	interleukin 1 beta	Mus musculus	128-136
27543415-7	2016	TCA pretreatment decreased LPS-induced morphological changes, NO production and IL-1beta release in primary microglia.	cinnamaldehyde	0-3	interleukin 1 beta	Mus musculus	80-88
27569861-3	2016	BHMB also reduced the mRNA expression of TNF-alpha, IL-6, and IL-1beta in LPS-stimulated RAW 264.7 cells.	5-bromo-2-hydroxy-4-methyl-benzaldehyde	0-4	interleukin 1 beta	Mus musculus	62-70
27796351-6	2016	Additionally, low receptor activator of nuclear factor-kappaB ligand (RANKL), tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and p65 immunochemistry staining were observed in strontium-treatment groups.	Strontium	190-199	interleukin 1 beta	Mus musculus	107-124
27373848-5	2016	Donepezil significantly reduced intra- and extracellular levels of various kinds of inflammatory mediators such as TNF-alpha, IL-1beta, IL-2, IL-6 and IL-18 after the LPS stimulation, and attenuated LPS-induced nuclear translocation of nuclear factor-kappa B (NF-kappaB).	Donepezil	0-9	interleukin 1 beta	Mus musculus	126-134
27779191-5	2016	Furthermore, stereotaxic injection of 25-HC into the corpus callosum of mouse brains induces microglial recruitment, interleukin-1beta production, and oligodendrocyte cell death in an NLRP3 inflammasome-dependent manner.	25-hydroxycholesterol	38-43	interleukin 1 beta	Mus musculus	117-134
27775097-4	2016	In CII-treated dendritic cells (DCs) and DC/CD4+ T coculture system, pretreatment with pharmacological antagonists of P2X7R (Suramin and A-438079) caused strong inhibition of production of Th17-promoting cytokines (IL-1beta, TGF-beta1, IL-23p19 and IL-6).	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	3-6	interleukin 1 beta	Mus musculus	215-223
27812336-0	2016	Piperine Suppresses Pyroptosis and Interleukin-1beta Release upon ATP Triggering and Bacterial Infection.	piperine	0-8	interleukin 1 beta	Mus musculus	35-52
27812336-0	2016	Piperine Suppresses Pyroptosis and Interleukin-1beta Release upon ATP Triggering and Bacterial Infection.	Adenosine Triphosphate	66-69	interleukin 1 beta	Mus musculus	35-52
27812336-4	2016	The results showed that piperine dose-dependently inhibited ATP-induced pyroptosis, thereby suppressing interleukin-1beta (IL-1beta) or high mobility group box-1 protein (HMGB1) release in LPS-primed bone marrow-derived macrophages and J774A.1 cells.	piperine	24-32	interleukin 1 beta	Mus musculus	104-121
27812336-4	2016	The results showed that piperine dose-dependently inhibited ATP-induced pyroptosis, thereby suppressing interleukin-1beta (IL-1beta) or high mobility group box-1 protein (HMGB1) release in LPS-primed bone marrow-derived macrophages and J774A.1 cells.	piperine	24-32	interleukin 1 beta	Mus musculus	123-131
27812336-4	2016	The results showed that piperine dose-dependently inhibited ATP-induced pyroptosis, thereby suppressing interleukin-1beta (IL-1beta) or high mobility group box-1 protein (HMGB1) release in LPS-primed bone marrow-derived macrophages and J774A.1 cells.	Adenosine Triphosphate	60-63	interleukin 1 beta	Mus musculus	123-131
27812336-6	2016	Moreover, piperine administration greatly reduced both peritoneal and serum IL-1beta levels in the mouse model intraperitoneally infected with Escherichia coli, suggestive of suppressing systemic inflammation and pyroptosis.	piperine	10-18	interleukin 1 beta	Mus musculus	76-84
27812336-7	2016	Our data indicated that piperine could protect macrophages from pyroptosis and reduced IL-1beta and HMGB1 release by suppressing ATP-induced AMPK activation, suggesting that piperine may become a potential therapeutic agent against bacterial sepsis.	piperine	24-32	interleukin 1 beta	Mus musculus	87-95
27812336-7	2016	Our data indicated that piperine could protect macrophages from pyroptosis and reduced IL-1beta and HMGB1 release by suppressing ATP-induced AMPK activation, suggesting that piperine may become a potential therapeutic agent against bacterial sepsis.	piperine	174-182	interleukin 1 beta	Mus musculus	87-95
27829992-9	2016	As a result, the levels of cytokines (TNF-alpha, IL-6, and IL-1beta) were down-regulated and inflammatory cell infiltration after renal IRI was attenuated by treatment with DEX.	Dexamethasone	173-176	interleukin 1 beta	Mus musculus	59-67
27830004-5	2016	Furthermore, FA markedly attenuated acetaminophen-induced serum tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta production, suppressed Toll-like receptor (TLR) 4 expression and dampened p38 mitogen-activated (MAPK) and nuclear factor kappa (NF-kappaB) activation.	Acetaminophen	36-49	interleukin 1 beta	Mus musculus	102-124
27830035-5	2016	It is concluded that the IL-1beta induced by PTZ-induced seizures may impair the synaptic plasticity alteration in hippocampus as well as learning and memory ability by PI3K/Akt signaling pathway.	Pentylenetetrazole	45-48	interleukin 1 beta	Mus musculus	25-33
27559013-7	2016	Further neurochemical assays suggested that LPS-induced overexpression of pro-inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) in the hippocampus and the prefrontal cortex (PFC) can also be reversed by trans-astaxanthin treatment.	astaxantin, calcium, citrus bioflavoid, lycopene, vitamin D3 drug combination	207-224	interleukin 1 beta	Mus musculus	102-110
27450485-6	2016	Casticin also inhibited the numbers of inflammatory cells and the levels of inflammatory cytokines TNF-alpha, IL-6, and IL-1beta production.	casticin	0-8	interleukin 1 beta	Mus musculus	120-128
27619992-4	2016	Studies of PMN infiltration during zymosan-induced peritonitis reveal that hyperglycemia enhances PMN recruitment not through inducing a high level of IL-17, which is the case in colitis, but through increasing F4/80+ macrophages in the peritoneal cavity, resulting in elevations of IL-6, IL-1beta, TNF-alpha, and CXCL1 production.	Zymosan	35-42	interleukin 1 beta	Mus musculus	289-297
27477353-6	2016	The results showed that taraxasterol attenuated CS-induced lung pathological changes, inflammatory cells infiltration, inflammatory cytokines TNF-alpha, IL-6 and IL-1beta production.	taraxasterol	24-36	interleukin 1 beta	Mus musculus	162-170
27477353-6	2016	The results showed that taraxasterol attenuated CS-induced lung pathological changes, inflammatory cells infiltration, inflammatory cytokines TNF-alpha, IL-6 and IL-1beta production.	Cesium	48-50	interleukin 1 beta	Mus musculus	162-170
27356303-9	2016	Organotypic spinal cord slices and DRG culture were performed to assess whether TCA attenuates expressions of pain mediators induced by interleukin 1beta.	Trichloroacetic Acid	80-83	interleukin 1 beta	Mus musculus	136-153
27356303-13	2016	Furthermore, TCA significantly suppressed expression of pain mediators induced by interleukin 1beta in spinal cord and DRG organotypic culture.	Trichloroacetic Acid	13-16	interleukin 1 beta	Mus musculus	82-99
27465039-8	2016	Butein inhibited IL-6, IL-1beta and TNF-alpha production and mRNA expression.	butein	0-6	interleukin 1 beta	Mus musculus	23-31
27784989-6	2016	Moringin pretreatment normalizes the aberrant Wnt-beta-catenin pathway, resulting in GSK3beta inhibition and beta-catenin upregulation, which regulates T-cell activation (CD4 and FoxP3), suppresses the main inflammatory mediators (IL-1beta, IL-6, and COX2), through activation of PPARgamma.	moringin	0-8	interleukin 1 beta	Mus musculus	231-239
27522260-5	2016	Further investigation indicated that astilbin prevented the renal damage against the expression of Thioredoxin-interacting protein (TXNIP) and its related inflammation signal pathway, including NLR pyrin domain-containing 3/Nuclear factor kappaB (NLRP3/NF-kappaB), which is associated with the up-regulation of interleukin-1beta (IL-1beta) and interleukin-18 (IL-18), and also presented a renal protective role by suppression oxidative stress.	astilbin	37-45	interleukin 1 beta	Mus musculus	311-328
27522260-5	2016	Further investigation indicated that astilbin prevented the renal damage against the expression of Thioredoxin-interacting protein (TXNIP) and its related inflammation signal pathway, including NLR pyrin domain-containing 3/Nuclear factor kappaB (NLRP3/NF-kappaB), which is associated with the up-regulation of interleukin-1beta (IL-1beta) and interleukin-18 (IL-18), and also presented a renal protective role by suppression oxidative stress.	astilbin	37-45	interleukin 1 beta	Mus musculus	330-338
27422366-5	2016	Involvement of TDAG8-dependent microglial activation and proinflammatory cytokine interleukin (IL)-1beta with CO2-evoked responses was investigated using microglial blocker, minocycline, and IL-1beta antagonist IL-1RA.	Carbon Dioxide	110-113	interleukin 1 beta	Mus musculus	82-104
27422366-10	2016	Central infusion of microglial activation blocker minocycline and IL-1beta antagonist IL-1RA attenuated CO2-evoked freezing.	Carbon Dioxide	104-107	interleukin 1 beta	Mus musculus	66-74
27422366-11	2016	Finally, CO2-evoked neuronal firing in patch-clamped subfornical organ neurons was dependent on acid sensor TDAG8 and IL-1beta.	Carbon Dioxide	9-12	interleukin 1 beta	Mus musculus	118-126
27522255-7	2016	Aortic mRNA expression of macrophage inflammatory cytokines, including MCP-1, iNOS, IL-1beta, IL-6, CXCL9 and CXCL11, was also reduced in PA-treated mice.	patchouli alcohol	138-140	interleukin 1 beta	Mus musculus	84-92
27393971-8	2016	In addition, it was observed that IMZ exposure could induce colonic inflammation characterized by infiltration of inflammatory cells, elevated levels of lipocalin-2 (lcn-2) in the feces, and increased mRNA levels of Tnf-alpha, IL-1beta, IL-22 and IFN-gamma in the colon.	enilconazole	34-37	interleukin 1 beta	Mus musculus	227-235
27688845-12	2016	CONCLUSIONS: Erythromycin has the ability to inhibit catabolic gene expression mediated by IL-1beta and TLR4 in chondrocytes in vitro and maintains cartilage matrix levels in experimental inflammatory joint destruction in vivo, suggesting that it possesses a chondroprotective activity.	Erythromycin	13-25	interleukin 1 beta	Mus musculus	91-99
27688845-10	2016	In addition, erythromycin inhibited IL-1beta and LPS-induced expression of MMPs and iNOS, as well as the positive regulatory loop between IL-1beta and Toll-like receptor 4 (TLR4) in articular chondrocytes.	Erythromycin	13-25	interleukin 1 beta	Mus musculus	36-44
27421105-5	2016	The mRNA expression of p65, inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) in macrophages exposed to fluoride was determined by quantitative real-time RT-PCR respectively.	Fluorides	168-176	interleukin 1 beta	Mus musculus	132-140
27421105-7	2016	Our results showed that fluoride had a dose-dependent effect on NF-kappaB activity, which coincided with LPS-induced mRNA expression of its downstream genes, iNOS and IL-1beta.	Fluorides	24-32	interleukin 1 beta	Mus musculus	167-175
27421105-10	2016	Therefore, we come to the conclusion that fluoride can regulate LPS-induced mRNA expression of iNOS and IL-1beta via NF-kappaB pathway in mouse peritoneal macrophages.	Fluorides	42-50	interleukin 1 beta	Mus musculus	104-112
27688845-10	2016	In addition, erythromycin inhibited IL-1beta and LPS-induced expression of MMPs and iNOS, as well as the positive regulatory loop between IL-1beta and Toll-like receptor 4 (TLR4) in articular chondrocytes.	Erythromycin	13-25	interleukin 1 beta	Mus musculus	138-146
27324858-7	2016	Scopoletin at the same dose also decreased the myeloperoxidase and adenosine-deaminase activities and nitric oxide, tumor necrosis factor-alpha, and interleukin-1beta levels (p &lt; 0.01).	Scopoletin	0-10	interleukin 1 beta	Mus musculus	149-166
27271513-0	2016	Enhanced p62 Is Responsible for Mitochondrial Pathway-Dependent Apoptosis and Interleukin-1beta Production at the Early Phase by Monosodium Urate Crystals in Murine Macrophage.	Uric Acid	129-145	interleukin 1 beta	Mus musculus	78-95
27352127-11	2016	The interleukin-1beta level in the serum and the number of natural killer cells in the lungs were significantly lower in the trichostatin A-treated group.	trichostatin A	125-139	interleukin 1 beta	Mus musculus	4-21
27546300-6	2016	Interestingly, ruxolitinib, especially at a dose of 200 mg/kg, dampened the overproduction of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IFN-gamma, IL-23 and IL-17A), which coincided with boosting the release of the anti-inflammatory cytokine IL-10.	ruxolitinib	15-26	interleukin 1 beta	Mus musculus	133-141
27271513-5	2016	Treatment of RAW 264.7 cells with MSU crystals induced activation of Bax, caspase-3, caspase-9, and PARP1 at the early phase, in addition to enhancing IL-1beta expression, but these findings were attenuated at the late phase.	Uric Acid	34-37	interleukin 1 beta	Mus musculus	151-159
27454847-6	2016	RESULTS: In RAW 264.7 cells, SA suppressed LPS-induced decrease in cell viability and nitrite accumulation to control values and inhibited up-regulation of TNF-alpha (65%) and IL-1beta (39%).	Shikimic Acid	29-31	interleukin 1 beta	Mus musculus	176-184
27271513-8	2016	The antioxidant ascorbic acid inhibited p62, caspase-9, and IL-1beta expression increased by MSU crystals.	Ascorbic Acid	16-29	interleukin 1 beta	Mus musculus	60-68
27498121-9	2016	In addition, liriodendrin decreased the production of the proinflammatory mediators including (TNF-alpha, IL-1beta, MCP-1, and IL-6) in lung tissues.	liriodendrin	13-25	interleukin 1 beta	Mus musculus	106-114
27394986-5	2016	The possible mechanisms of Gent activities were explored by evaluating expression levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6 using real-time fluorogenic PCR and expression levels of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) using Western blotting.	gentiopicroside	27-31	interleukin 1 beta	Mus musculus	133-150
27394986-5	2016	The possible mechanisms of Gent activities were explored by evaluating expression levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6 using real-time fluorogenic PCR and expression levels of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) using Western blotting.	gentiopicroside	27-31	interleukin 1 beta	Mus musculus	152-160
27412397-0	2016	Erratum to: Enhanced p62 is Responsible for Mitochondrial Pathway-Dependent Apoptosis and Interleukin-1beta Production at the Early Phase by Monosodium Urate Crystals in Murine Macrophage.	Uric Acid	141-157	interleukin 1 beta	Mus musculus	90-107
27440860-5	2016	Sorafenib induces differentiation of BMCs into suppressive dendritic cells that inhibit autologous T-cell proliferation and stimulate CD4(+) T cells to express increased IL-1beta, IL-2, IL-4, IL-10, IFN-gamma and TNF-alpha, and reduced levels of IL-6 and CD25, which indicates that sorafenib-induced dendritic cells represent a distinct cellular subset with unique properties.	Sorafenib	0-9	interleukin 1 beta	Mus musculus	170-178
27394986-7	2016	In addition, the mRNA expression of TNF-alpha, IL-1beta, IL-6 and the overexpression of COX-2 and iNOS proteins in the colon were down-regulated by Gent treatment.	gentiopicroside	148-152	interleukin 1 beta	Mus musculus	47-55
27394986-8	2016	To our knowledge, this is the first study to demonstrate that Gent treatment can exert anti-inflammatory effects on experimental acute colitis through attenuating the expression levels of TNF-alpha, IL-1beta, IL-6, iNOS and COX-2, and it may present the therapeutic potential in the treatment of colitis.	gentiopicroside	62-66	interleukin 1 beta	Mus musculus	199-207
27600119-5	2016	The mRNA expression of interleukin (IL)-1beta (1.33+-0.38-fold) and IL-6 (0.64+-0.40-fold) in the brain tissue of beta-PGG-treated animals markedly decreased compared with that observed in the control groups (3.86+-0.91 and 2.45+-1.12-fold, respectively) and in the other LPS-administered groups.	beta-pgg	114-122	interleukin 1 beta	Mus musculus	23-45
26931732-4	2016	alpha-Solanine also reduced the production and mRNA expression of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) induced by LPS.	alpha-solanine	0-14	interleukin 1 beta	Mus musculus	133-150
26931732-4	2016	alpha-Solanine also reduced the production and mRNA expression of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) induced by LPS.	alpha-solanine	0-14	interleukin 1 beta	Mus musculus	152-160
26931732-6	2016	In an in vivo experiment of LPS-induced endotoxemia, treatment with alpha-solanine suppressed mRNA expressions of iNOS, COX-2, IL-6, TNF-alpha, and IL-1beta, and the activation of NF-kappaB in liver.	alpha-solanine	68-82	interleukin 1 beta	Mus musculus	148-156
27218415-6	2016	EGCG also decreased colonic protein levels of IL-1beta, IL-6, and tumor necrosis factor-alpha, as well as colonic lipid peroxides compared to DSS-treated controls.	epigallocatechin gallate	0-4	interleukin 1 beta	Mus musculus	46-54
27733273-5	2016	Gomisin N inhibited LPS-induced expression of mRNAs for inflammation-related genes (inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha) in BV-2 cells.	schizandrin B	0-9	interleukin 1 beta	Mus musculus	148-170
27209403-8	2016	Further neurochemical assays suggested that pretreatment with fisetin reversed LPS-induced overexpression of pro-inflammatory cytokine (IL-1beta, IL-6 and TNF-alpha) in the hippocampus and the prefrontal cortex (PFC).	fisetin	62-69	interleukin 1 beta	Mus musculus	136-144
27234527-1	2016	Gouty arthritis is a type of monosodium urate (MSU) crystals-induced inflammation in the articular tissue and shows the increased levels of neutrophil infiltration and IL-1beta secretion.	Uric Acid	29-45	interleukin 1 beta	Mus musculus	168-176
27509914-4	2016	The effects of lycorine on IL-1beta-induced upregulation of MMPs and activation of mitogen-activated protein kinase pathways were detected by western blot analysis and reverse transcription-quantitative polymerase chain reaction.	lycorine	15-23	interleukin 1 beta	Mus musculus	27-35
27509914-6	2016	In the present study, it was demonstrated for the first time, to the best of our knowledge, that lycorine (LY) suppressed interleukin-1beta (IL-1beta)-induced synthesis of MMP-3 and MMP-13 in vitro.	lycorine	97-105	interleukin 1 beta	Mus musculus	122-139
27509914-6	2016	In the present study, it was demonstrated for the first time, to the best of our knowledge, that lycorine (LY) suppressed interleukin-1beta (IL-1beta)-induced synthesis of MMP-3 and MMP-13 in vitro.	lycorine	97-105	interleukin 1 beta	Mus musculus	141-149
27234527-1	2016	Gouty arthritis is a type of monosodium urate (MSU) crystals-induced inflammation in the articular tissue and shows the increased levels of neutrophil infiltration and IL-1beta secretion.	Uric Acid	47-50	interleukin 1 beta	Mus musculus	168-176
27509914-6	2016	In the present study, it was demonstrated for the first time, to the best of our knowledge, that lycorine (LY) suppressed interleukin-1beta (IL-1beta)-induced synthesis of MMP-3 and MMP-13 in vitro.	lycorine	107-109	interleukin 1 beta	Mus musculus	122-139
27234527-7	2016	The results demonstrated that EGCG inhibited MSU-induced neutrophil infiltration and IL-1beta secretion.	epigallocatechin gallate	30-34	interleukin 1 beta	Mus musculus	85-93
27509914-6	2016	In the present study, it was demonstrated for the first time, to the best of our knowledge, that lycorine (LY) suppressed interleukin-1beta (IL-1beta)-induced synthesis of MMP-3 and MMP-13 in vitro.	lycorine	107-109	interleukin 1 beta	Mus musculus	141-149
27234527-8	2016	Furthermore, EGCG decreased MSU-triggered neutrophil cytosolic factor 1 and NLRP3 protein expression, limiting pro-inflammatory mediator secretion such as IL-1beta, IL-6, monocyte chemoattractant protein-1, and serum amyloid A.	epigallocatechin gallate	13-17	interleukin 1 beta	Mus musculus	155-163
27224271-4	2016	Gamma-terpinene treatment was found to reduce the production of proinflammatory cytokines, such as interleukin-1beta and interleukin-6, and enhance that of the anti-inflammatory cytokine interleukin-10.	gamma-terpinene	0-15	interleukin 1 beta	Mus musculus	99-116
27311540-8	2016	While venlafaxine (4 mg/kg) reversed the elevated serum levels of IL-1beta and IL-6 found in chronically stressed mice, agomelatine (4 and 8 mg/kg) failed to show such a reversal.	Venlafaxine Hydrochloride	6-17	interleukin 1 beta	Mus musculus	66-74
27453424-11	2016	Agmatine pre-treatment at 40mg/kg ameliorated LPS-induced neuroinflammation by attenuating brain IL-1beta and TNF-alpha level.	Agmatine	0-8	interleukin 1 beta	Mus musculus	97-105
27224271-7	2016	Moreover, nimesulide treatment also abrogated the inhibitory effect of gamma-terpinene on interleukin-1beta and interleukin-6.	nimesulide	10-20	interleukin 1 beta	Mus musculus	90-107
27224271-7	2016	Moreover, nimesulide treatment also abrogated the inhibitory effect of gamma-terpinene on interleukin-1beta and interleukin-6.	gamma-terpinene	71-86	interleukin 1 beta	Mus musculus	90-107
27706063-6	2016	In addition, koumine-pretreated RAW 264.7 macrophages exhibited reduction of LPS-induced levels of TNF-alpha, IL-1beta, and IL-6 mRNA.	koumine	13-20	interleukin 1 beta	Mus musculus	110-118
27667443-6	2016	Surprisingly, mouse monocytes displayed a distinct response to acetate treatment, elevating GM-CSF, IL-1alpha, and IL-1beta cytokine expression.	Acetates	63-70	interleukin 1 beta	Mus musculus	115-123
27683551-6	2016	Chronic PAO supplementation also lowers systemic interleukin-1beta (IL-1beta) and IL-18 concentrations in vivo in hyperlipidemic mice.	palmitoleic acid	8-11	interleukin 1 beta	Mus musculus	49-66
27683551-6	2016	Chronic PAO supplementation also lowers systemic interleukin-1beta (IL-1beta) and IL-18 concentrations in vivo in hyperlipidemic mice.	palmitoleic acid	8-11	interleukin 1 beta	Mus musculus	68-76
27584700-6	2016	Furthermore, allicin supplementation significantly decreased the levels of proinflammatory tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 and suppressed the expression of sterol regulatory element-binding protein-1 (SREBP-1) (p &lt; 0.05).	allicin	13-20	interleukin 1 beta	Mus musculus	126-148
27658533-6	2016	IND administration induced significant ulceration, bleeding, and oedema in the stomach or small intestine of wild-type (WT) mice; however, such severe damages to the GI significantly decreased in fat-1 transgenic (TG) mice (P &lt; 0.001), which exhibited decreased cyclooxygenase-2 expression and apoptosis, decreased interleukin-1beta and FAS concentrations, and increased heme oxygenase-1 concentration.	Indomethacin	0-3	interleukin 1 beta	Mus musculus	318-335
27663791-8	2016	The DHA-depleted group showed significantly increased TBI-induced expression of pro-inflammatory cytokines TNF-alpha, IL-1beta, and IL-6 in the brain as well as slower functional recovery from motor deficits compared to the adequate ALA group.	Docosahexaenoic Acids	4-7	interleukin 1 beta	Mus musculus	118-126
27658624-7	2016	Some of the protective effects of MOS were likely be mediated directly through local macrophages because MOS dose-dependently inhibited IL-1b and G-CSF induction following in vitro DSS challenge and IL1a, IL1b, G-SCF-, and IL6 increases after LPS treatment in mouse macrophage cell line RAW264.7.	dss	181-184	interleukin 1 beta	Mus musculus	136-141
27521339-4	2016	Specifically, we show that in human and mouse innate immune cells CP-456,773 is an inhibitor of the cellular release of IL-1beta, IL-1alpha, and IL-18, that CP-456,773 prevents inflammasome activation induced by disease-relevant soluble and crystalline NLRP3 stimuli, and that CP-456,773 inhibits R848- and imiquimod-induced IL-1beta release.	cp-456	157-163	interleukin 1 beta	Mus musculus	325-333
27261736-2	2016	Results revealed that EPS could significantly induce the production of nitric oxide (NO), tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta and enhance phagocytic activity in RAW 264.7 cells.	eps	22-25	interleukin 1 beta	Mus musculus	128-150
27261736-5	2016	Furthermore, pretreatment of RAW 264.7 cells with specific inhibitors of NF-kappaB and MAPKs significantly attenuated EPS-induced TNF-alpha and IL-1beta production.	eps	118-121	interleukin 1 beta	Mus musculus	144-152
27521339-3	2016	In this study, we further define the pharmacology of the previously reported NLRP3 inflammasome-selective, IL-1beta processing inhibitor CP-456,773 (also known as MCC950), and we demonstrate its efficacy in two in vivo models of inflammation.	cp-456	137-143	interleukin 1 beta	Mus musculus	107-115
27521339-4	2016	Specifically, we show that in human and mouse innate immune cells CP-456,773 is an inhibitor of the cellular release of IL-1beta, IL-1alpha, and IL-18, that CP-456,773 prevents inflammasome activation induced by disease-relevant soluble and crystalline NLRP3 stimuli, and that CP-456,773 inhibits R848- and imiquimod-induced IL-1beta release.	cp-456	66-72	interleukin 1 beta	Mus musculus	120-128
27521339-4	2016	Specifically, we show that in human and mouse innate immune cells CP-456,773 is an inhibitor of the cellular release of IL-1beta, IL-1alpha, and IL-18, that CP-456,773 prevents inflammasome activation induced by disease-relevant soluble and crystalline NLRP3 stimuli, and that CP-456,773 inhibits R848- and imiquimod-induced IL-1beta release.	cp-456	157-163	interleukin 1 beta	Mus musculus	325-333
27207922-5	2016	RESULTS: We demonstrated that fluoxetine significantly suppressed NLRP3 inflammasome activation, subsequent caspase-1 cleavage, and interleukin-1beta secretion in both peripheral macrophages and central microglia.	Fluoxetine	30-40	interleukin 1 beta	Mus musculus	132-149
27292196-13	2016	Moreover, EOS1 and BIS exhibited a significant anti-inflammatory effect (p&lt;0.001) in the pleurisy model of inflammation, which seems to be related to a significant reduction (p&lt;0.05) of the pro-inflammatory cytokine TNF-alpha in BIS treatment, and of the pro-inflammatory cytokine IL-1beta (p&lt;0.01) in EOS1 treatment.	1,1,5,5-tetrafluorophosphopentylphosphonic acid adenylate ester	19-22	interleukin 1 beta	Mus musculus	287-295
27585971-5	2016	Colchicine inhibited the protein expression of cleaved caspase-1 and mature IL-1beta, without affecting the mRNA expression of NLRP3 and IL-1beta.	Colchicine	0-10	interleukin 1 beta	Mus musculus	76-84
27528423-4	2016	The stimulation of lung TAMs with LPS+ATP increased the release of IL-1beta.	Adenosine Triphosphate	38-41	interleukin 1 beta	Mus musculus	67-75
27528423-5	2016	The inhibition of NLRP3 by means of glybenclamide significantly reduced IL-1beta release.	Glyburide	36-49	interleukin 1 beta	Mus musculus	72-80
27528423-10	2016	In contrast, the depletion of TAMs by means of clodronate liposomes reduced lung tumorigenesis, associated to lower in vivo release of IL-1alpha and IL-1beta.In conclusion, our data imply lung tumor lesions are populated by macrophages which pro-tumor activity is regulated by the activation of the NLRP3 inflammasome that leads to the release of IL-1alpha and IL-1beta in a caspase-11/caspase-1-dependent manner.	tams	30-34	interleukin 1 beta	Mus musculus	149-157
27528423-10	2016	In contrast, the depletion of TAMs by means of clodronate liposomes reduced lung tumorigenesis, associated to lower in vivo release of IL-1alpha and IL-1beta.In conclusion, our data imply lung tumor lesions are populated by macrophages which pro-tumor activity is regulated by the activation of the NLRP3 inflammasome that leads to the release of IL-1alpha and IL-1beta in a caspase-11/caspase-1-dependent manner.	tams	30-34	interleukin 1 beta	Mus musculus	361-369
27528423-10	2016	In contrast, the depletion of TAMs by means of clodronate liposomes reduced lung tumorigenesis, associated to lower in vivo release of IL-1alpha and IL-1beta.In conclusion, our data imply lung tumor lesions are populated by macrophages which pro-tumor activity is regulated by the activation of the NLRP3 inflammasome that leads to the release of IL-1alpha and IL-1beta in a caspase-11/caspase-1-dependent manner.	Clodronic Acid	47-57	interleukin 1 beta	Mus musculus	149-157
27632566-12	2016	Furthermore, hydroxyapatite crystals, a component of dental calculus, induced IL-1beta in mouse macrophages, and baked calculus induced IL-1beta in lipid A-primed human PMNs and PBMCs.	Durapatite	13-27	interleukin 1 beta	Mus musculus	78-86
27632566-12	2016	Furthermore, hydroxyapatite crystals, a component of dental calculus, induced IL-1beta in mouse macrophages, and baked calculus induced IL-1beta in lipid A-primed human PMNs and PBMCs.	Lipid A	148-155	interleukin 1 beta	Mus musculus	136-144
28239073-6	2016	In addition, levels of mRNA expression of the markers of keratinocytes, i.e., IL-1beta, S100A8, and S100A9, were dramatically elevated in IMQ-treated mice.	Imiquimod	138-141	interleukin 1 beta	Mus musculus	78-86
27589957-6	2016	Central blockade of interleukin-1beta (IL-1beta) reversed the anxiety-like phenotype of EAE mice, an effect associated with the concomitant rescue of dopamine (DA)-regulated spontaneous behavior, and DA-CB1R neurotransmission, leading to the rescue of striatal CB1R sensitivity.	Dopamine	150-158	interleukin 1 beta	Mus musculus	20-37
27589957-6	2016	Central blockade of interleukin-1beta (IL-1beta) reversed the anxiety-like phenotype of EAE mice, an effect associated with the concomitant rescue of dopamine (DA)-regulated spontaneous behavior, and DA-CB1R neurotransmission, leading to the rescue of striatal CB1R sensitivity.	Dopamine	150-158	interleukin 1 beta	Mus musculus	39-47
27589957-6	2016	Central blockade of interleukin-1beta (IL-1beta) reversed the anxiety-like phenotype of EAE mice, an effect associated with the concomitant rescue of dopamine (DA)-regulated spontaneous behavior, and DA-CB1R neurotransmission, leading to the rescue of striatal CB1R sensitivity.	Dopamine	160-162	interleukin 1 beta	Mus musculus	20-37
27589957-6	2016	Central blockade of interleukin-1beta (IL-1beta) reversed the anxiety-like phenotype of EAE mice, an effect associated with the concomitant rescue of dopamine (DA)-regulated spontaneous behavior, and DA-CB1R neurotransmission, leading to the rescue of striatal CB1R sensitivity.	Dopamine	160-162	interleukin 1 beta	Mus musculus	39-47
27585971-6	2016	Although treatment with recombinant IL-1beta (0.1 mug/kg) did not change the severity of small intestinal damage, the preventive effects of colchicine were abolished by supplementation with the same dose of recombinant IL-1beta.	Colchicine	140-150	interleukin 1 beta	Mus musculus	219-227
27464336-11	2016	Although alcohol increased TNF-alpha, IL-6, and IL-1beta mRNA, no change in key components of the NLRP3 inflammasome (NLRP3, ACS, and cleaved caspase-1) was detected suggesting alcohol did not increase pyroptosis.	Alcohols	9-16	interleukin 1 beta	Mus musculus	48-56
27265145-3	2016	Here, we found that andrographolide (Andro), a small-molecule natural product, alleviated imiquimod- but not interleukin 23 (IL-23)-induced psoriasis in mice with reducing expressions of IL-23 and IL-1beta in the skin.	andrographolide	20-35	interleukin 1 beta	Mus musculus	197-205
27265145-3	2016	Here, we found that andrographolide (Andro), a small-molecule natural product, alleviated imiquimod- but not interleukin 23 (IL-23)-induced psoriasis in mice with reducing expressions of IL-23 and IL-1beta in the skin.	andrographolide	37-42	interleukin 1 beta	Mus musculus	197-205
27318179-5	2016	SA also inhibited CP-induced MPO, MDA, TNF-alpha and IL-1beta production and up-regulated the activities of SOD and GSH-PX decreased by CP.	sappanone A	0-2	interleukin 1 beta	Mus musculus	53-61
27498777-7	2016	RESULTS: In rotenone-treated BV2 cells, MK-4 (0.5-20 mumol/L) dose-dependently suppressed the upregulation in the expression of iNOS and COX-2 in the cells, as well as the production of TNF-alpha and IL-1beta in the cultured media.	Rotenone	12-20	interleukin 1 beta	Mus musculus	200-208
27498777-7	2016	RESULTS: In rotenone-treated BV2 cells, MK-4 (0.5-20 mumol/L) dose-dependently suppressed the upregulation in the expression of iNOS and COX-2 in the cells, as well as the production of TNF-alpha and IL-1beta in the cultured media.	menatetrenone	40-44	interleukin 1 beta	Mus musculus	200-208
27588050-6	2016	The IL-1beta mRNA and protein expression levels were significantly elevated in the normal saline injection and propylene glycol injection groups compared with the blank control group and (P&lt;0.01).	Sodium Chloride	90-96	interleukin 1 beta	Mus musculus	4-12
27588050-6	2016	The IL-1beta mRNA and protein expression levels were significantly elevated in the normal saline injection and propylene glycol injection groups compared with the blank control group and (P&lt;0.01).	Propylene Glycol	111-127	interleukin 1 beta	Mus musculus	4-12
27588050-7	2016	In TL (TL2 and TL3)- and dexamethasone-treated mice, IL-1beta expression levels were significantly decreased, as compared with the normal saline and propylene glycol injection groups (P&lt;0.05).	Dexamethasone	25-38	interleukin 1 beta	Mus musculus	53-61
27270078-7	2016	Furthermore, parthenolide also significantly reduced the expression of pro-inflammatory cytokines such as IFN-gamma, TNF-alpha, IL-17A, IL-1beta and IL-6 in lipopolysaccharide (LPS)-stimulated RAW264.7 cells in vitro.	parthenolide	13-25	interleukin 1 beta	Mus musculus	136-144
27351827-9	2016	Caffeic acid phenethyl ester also abolished LPS-induced expression of inducible nitric oxide synthase, interleukin-1beta and tumor necrosis factor alpha, which may be relevant to the inhibitory effect of Am80 on expression of these pro-inflammatory factors.	caffeic acid phenethyl ester	0-28	interleukin 1 beta	Mus musculus	103-152
27588050-0	2016	Therapeutic effects of triptolide via the inhibition of IL-1beta expression in a mouse model of ulcerative colitis.	triptolide	23-33	interleukin 1 beta	Mus musculus	56-64
27089940-4	2016	We found that RA had a dramatic suppressive effect on IL-17A and IL-17F production by gammadelta T cells stimulated with IL-1beta and IL-23.	Tretinoin	14-16	interleukin 1 beta	Mus musculus	121-129
27240136-4	2016	In addition, isocyperol downregulated the LPS-induced expression of several proinflammatory cytokines, such as interleukin-1beta (IL-1beta), IL-6, and monocyte chemotactic protein-1 (MCP-1).	isocyperol	13-23	interleukin 1 beta	Mus musculus	111-128
27240136-4	2016	In addition, isocyperol downregulated the LPS-induced expression of several proinflammatory cytokines, such as interleukin-1beta (IL-1beta), IL-6, and monocyte chemotactic protein-1 (MCP-1).	isocyperol	13-23	interleukin 1 beta	Mus musculus	130-138
27318179-9	2016	In vitro, SA dose-dependently inhibited CP-induced TNF-alpha and IL-1beta production and NF-kappaB activation in HK-2 cells.	sappanone A	10-12	interleukin 1 beta	Mus musculus	65-73
27376853-11	2016	Notably, berberine treatment rescued surgery-induced cognitive impairment and inhibited the release of IBA1, IL-1beta, and IL-6 in the hippocampus.	Berberine	9-18	interleukin 1 beta	Mus musculus	109-117
27430883-4	2016	In this study, we examined the effects of BITC on inflammasome-mediated interleukin-1beta (IL-1beta) production in E. coli lipopolysaccharide (LPS)-stimulated BV2 microglial cells.	benzyl isothiocyanate	42-46	interleukin 1 beta	Mus musculus	91-99
27376853-12	2016	In line with the in vivo study, berberine treatment suppressed LPS-stimulated production of TNF-alpha and IL-1beta in BV2 cells.	Berberine	32-41	interleukin 1 beta	Mus musculus	106-114
26928963-8	2016	The CRTH2 antagonist OC-459, but not the DP antagonist MK0524, reduced inflammation scores and decreased TNF-alpha, IL-1beta, and IL-6 as compared with control mice.	(5-fluoro-2-methyl-3-quinolin-2-ylmethylindo-1-yl)acetic acid	21-27	interleukin 1 beta	Mus musculus	116-124
27722140-10	2016	The release and expression of cytokines, such as TNF-alpha, interleukin (IL)-1beta, IL-6, and IL-10, were also significantly increased in response to treatment with WEMF.	wemf	165-169	interleukin 1 beta	Mus musculus	60-82
27112251-7	2016	DSS increased disease severity, serum CRP and cytokines IL-1beta and IL-6, but decreased bacterial species richness, and shifted bacterial community composition.	Dextran Sulfate	0-3	interleukin 1 beta	Mus musculus	56-64
27061744-5	2016	Our results elucidate that MINO down-regulated the isoflurane-induced and surgery-induced enhancement in the protein levels of pro-inflammatory cytokine tumour necrosis factor alpha, interleukin (IL)-1beta, interferon-gamma and microglia marker Iba-1, and up-regulated protein levels of the anti-inflammatory cytokine IL-4 and IL-10.	Isoflurane	51-61	interleukin 1 beta	Mus musculus	183-205
26748661-7	2016	Tetrandrine could inhibit IL-6, IL-1beta, and TNF-alpha expression via blocking the nuclear translocation of nuclear factor (NF)-kappaB p65 in LPS-induced RAW 264.7 cells.	tetrandrine	0-11	interleukin 1 beta	Mus musculus	32-40
27429139-3	2016	This study showed for the first time that CPF and CBZ dose-relatedly reduced macrophage lysosomal enzyme activity and LPS-induced production of IL-1beta, TNFalpha and NO.	carbendazim	50-53	interleukin 1 beta	Mus musculus	144-152
27262364-3	2016	Inflammasome activation in renal dendritic cells and the resulting interleukin (IL)-1beta and IL-18 production were markedly reduced by CP-456,773 treatment both ex vivo and in vivo.	cp-456	136-142	interleukin 1 beta	Mus musculus	67-89
27430303-7	2016	The effect of emodin-8-O-glucuronic acid on the secretion of TNF-alpha, IL-1beta and IL-10 was attenuated by the knockdown of HSP70.	emodin-8-o-glucuronic acid	14-40	interleukin 1 beta	Mus musculus	72-80
27522478-7	2016	Intrathecal injection of the anti-inflammatory cytokine interleukin-4 or CCL3-neutralizing antibody alleviated CCI-induced inflammation, suppressing the CCI-induced upregulation of tumor necrosis factor-alpha and interleukin-1beta in the serum and spinal cord, restoring the CCI-induced upregulation of CCL3 and CCR5, and suppressing the CCI-induced activation of p38 mitogen-activated protein kinase.	CCI	111-114	interleukin 1 beta	Mus musculus	213-230
27430303-5	2016	The results obtained from an ELISA assay showed that emodin-8-O-glucuronic acid inhibited the elevated expression levels of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-10 in the LPS-stimulated Raw 264.7 cells, which occurred in a dose-dependent manner.	emodin-8-o-glucuronic acid	53-79	interleukin 1 beta	Mus musculus	165-187
27522478-7	2016	Intrathecal injection of the anti-inflammatory cytokine interleukin-4 or CCL3-neutralizing antibody alleviated CCI-induced inflammation, suppressing the CCI-induced upregulation of tumor necrosis factor-alpha and interleukin-1beta in the serum and spinal cord, restoring the CCI-induced upregulation of CCL3 and CCR5, and suppressing the CCI-induced activation of p38 mitogen-activated protein kinase.	CCI	153-156	interleukin 1 beta	Mus musculus	213-230
27522478-7	2016	Intrathecal injection of the anti-inflammatory cytokine interleukin-4 or CCL3-neutralizing antibody alleviated CCI-induced inflammation, suppressing the CCI-induced upregulation of tumor necrosis factor-alpha and interleukin-1beta in the serum and spinal cord, restoring the CCI-induced upregulation of CCL3 and CCR5, and suppressing the CCI-induced activation of p38 mitogen-activated protein kinase.	CCI	153-156	interleukin 1 beta	Mus musculus	213-230
27522478-7	2016	Intrathecal injection of the anti-inflammatory cytokine interleukin-4 or CCL3-neutralizing antibody alleviated CCI-induced inflammation, suppressing the CCI-induced upregulation of tumor necrosis factor-alpha and interleukin-1beta in the serum and spinal cord, restoring the CCI-induced upregulation of CCL3 and CCR5, and suppressing the CCI-induced activation of p38 mitogen-activated protein kinase.	CCI	153-156	interleukin 1 beta	Mus musculus	213-230
27133730-6	2016	Esculetin significantly reduced LPS-induced elevated levels of pro-inflammatory cytokines including interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in serum and hippocampus.	esculetin	0-9	interleukin 1 beta	Mus musculus	122-139
27348412-5	2016	Inhibition of CII during infection with Escherichia coli normalized serum concentrations of interleukin 1beta (IL-1beta) and IL-10 to those in mice treated with dead bacteria and impaired control of bacteria.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	14-17	interleukin 1 beta	Mus musculus	92-109
27348412-5	2016	Inhibition of CII during infection with Escherichia coli normalized serum concentrations of interleukin 1beta (IL-1beta) and IL-10 to those in mice treated with dead bacteria and impaired control of bacteria.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	14-17	interleukin 1 beta	Mus musculus	111-119
29441852-4	2016	Methyl jasmonate treatment effectively inhibited LPS-induced production of pro-inflammatory mediators (nitric oxide and prostaglandin E2) and cytokines (tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6) in a concentration-dependent manner.	methyl jasmonate	0-16	interleukin 1 beta	Mus musculus	182-204
26813341-4	2016	Mechanistically, we determined that (i) Eritoran blocks high-mobility group B1 (HMGB1)-mediated, TLR4-dependent signaling in vitro and circulating HMGB1 in vivo, and an HMGB1 inhibitor protects against PR8; (ii) Eritoran inhibits pulmonary lung edema associated with ALI; (iii) interleukin (IL)-1beta contributes significantly to PR8-induced lethality, as evidenced by partial protection by IL-1 receptor antagonist (IL-1Ra) therapy.	eritoran	40-48	interleukin 1 beta	Mus musculus	278-300
27133730-6	2016	Esculetin significantly reduced LPS-induced elevated levels of pro-inflammatory cytokines including interleukin-6 (IL-6), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in serum and hippocampus.	esculetin	0-9	interleukin 1 beta	Mus musculus	141-149
27578571-7	2016	Compared with CLP group, the mice in ML+CLP group showed lowered levels of ALT, AST, Cr, TNF-alpha and IL-1beta and increased levels of IL-10 and TGF-beta; in SMP+CLP group, the levels of ALT, AST, Cr, TNF-alpha and IL-1beta were decreased and TGF-beta increased.	smp	159-162	interleukin 1 beta	Mus musculus	103-111
27589725-8	2016	Specific TLR9 inhibitor, ODN 2088 pretreatment can significantly attenuate mtDNA induced ALI and systemic inflammation, as demonstrated by improved lung injury score, decreased lung wet/dry ratio, BALF total protein concentration, and decreased systemic level of IL-1beta, IL-6 and HMGB1.	iCpG-ODN	25-33	interleukin 1 beta	Mus musculus	263-271
27527870-9	2016	Ethanol caused pancreatic inflammation which was indicated by the induction of TNF-alpha, IL-1beta, IL-6, MCP-1 and CCR2, and the increase of CD68 positive macrophages in the pancreas.	Ethanol	0-7	interleukin 1 beta	Mus musculus	90-98
27527873-6	2016	Instead, LysMCre-fur(fl/fl) mice had elevated serum IL-1beta levels and reduced numbers of splenocytes.	lysmcre-fur	9-20	interleukin 1 beta	Mus musculus	52-60
27578571-8	2016	In MES+CLP group, the mice showed obviously increased 72-h survival with lowered levels of ALT, AST, BUN, Cr, TNF-alpha, IL-6 and IL-1beta, increased levels of IL-10 and TGF-beta, and alleviated liver and kidney damages.	2-(N-morpholino)ethanesulfonic acid	3-6	interleukin 1 beta	Mus musculus	130-138
28598075-7	2016	The expression levels of NLRP3, caspase-1, IL-1beta and IL-18 decreased with the increase of TSA concentration.	tanshinone	93-96	interleukin 1 beta	Mus musculus	43-51
27311643-6	2016	Treatment of mBMDCs with exogenous ATP induced release of high levels of IL-1beta and IL-18, and this release was also significantly inhibited by apyrase and A438079.	Adenosine Triphosphate	35-38	interleukin 1 beta	Mus musculus	73-81
27311643-10	2016	ATP induces ROS production via NADPH oxidase, and ROS activate inflammasomes, leading to caspase-1-dependent processing of pro-cytokines and release of IL-1beta and IL-18.	Adenosine Triphosphate	0-3	interleukin 1 beta	Mus musculus	152-160
27311643-10	2016	ATP induces ROS production via NADPH oxidase, and ROS activate inflammasomes, leading to caspase-1-dependent processing of pro-cytokines and release of IL-1beta and IL-18.	Reactive Oxygen Species	50-53	interleukin 1 beta	Mus musculus	152-160
27483033-2	2016	In addition, the chain-like structure and reactive surface silanols also allow fumed silica to activate the NLRP3 inflammasome, leading to IL-1beta production.	silanol	59-67	interleukin 1 beta	Mus musculus	139-147
27483033-2	2016	In addition, the chain-like structure and reactive surface silanols also allow fumed silica to activate the NLRP3 inflammasome, leading to IL-1beta production.	Silicon Dioxide	85-91	interleukin 1 beta	Mus musculus	139-147
27578571-7	2016	Compared with CLP group, the mice in ML+CLP group showed lowered levels of ALT, AST, Cr, TNF-alpha and IL-1beta and increased levels of IL-10 and TGF-beta; in SMP+CLP group, the levels of ALT, AST, Cr, TNF-alpha and IL-1beta were decreased and TGF-beta increased.	smp	159-162	interleukin 1 beta	Mus musculus	216-224
27345627-6	2016	RESULTS: In LPS-treated BV2 cells and primary microglial cells, pretreatment with probucol (1, 5, 10 mumol/L) dose-dependently inhibited the release of NO, PGE2, IL-1beta and IL-6, which occurred at the transcription levels.	Probucol	82-90	interleukin 1 beta	Mus musculus	162-170
27267730-5	2016	Up-regulation of proinflammatory cytokines induced by LPS including TNF-alpha, IL-1beta and IL-6 were markedly suppressed by DHC treatment.	dihydrocapsaicin	125-128	interleukin 1 beta	Mus musculus	79-87
27385778-10	2016	These PM pores also facilitated the efflux of cytosolic ATP and influx of extracellular Ca(2+) Although lanthanides and Gsdmd deletion both suppressed PM pore activity and pyroptotic lysis, robust IL-1beta release was observed in lanthanide-treated BMDMs but not in Gsdmd-deficient cells.	Adenosine Triphosphate	56-59	interleukin 1 beta	Mus musculus	197-205
27385778-10	2016	These PM pores also facilitated the efflux of cytosolic ATP and influx of extracellular Ca(2+) Although lanthanides and Gsdmd deletion both suppressed PM pore activity and pyroptotic lysis, robust IL-1beta release was observed in lanthanide-treated BMDMs but not in Gsdmd-deficient cells.	Lanthanoid Series Elements	104-115	interleukin 1 beta	Mus musculus	197-205
27385778-10	2016	These PM pores also facilitated the efflux of cytosolic ATP and influx of extracellular Ca(2+) Although lanthanides and Gsdmd deletion both suppressed PM pore activity and pyroptotic lysis, robust IL-1beta release was observed in lanthanide-treated BMDMs but not in Gsdmd-deficient cells.	Lanthanoid Series Elements	104-114	interleukin 1 beta	Mus musculus	197-205
27054666-3	2016	In the present study, when mice were continuously exposed to TiO2 NPs at 2.5, 5 or 10mg/kg BW by intragastric administration for 90days, obvious histopathological changes, and great alterations of NF-kappaB and its inhibitor I-kappaB, as well as TNF-alpha, IL-1beta, IL-6 and IFN-alpha expression were induced.	titanium dioxide	61-65	interleukin 1 beta	Mus musculus	257-265
27421477-2	2016	The NLRP3 inflammasome, a multiprotein intracellular pattern recognition receptor complex that facilitates the cleavage and secretion of the proinflammatory cytokines IL-1beta and IL-18, can be inhibited by ethanol, and we sought to better understand the mechanism through which this occurs and whether chemically similar molecules exert comparable effects.	Ethanol	207-214	interleukin 1 beta	Mus musculus	167-175
27421477-3	2016	We show that ethanol can specifically inhibit activation of the NLRP3 inflammasome, resulting in attenuated IL-1beta and caspase-1 cleavage and secretion, as well as diminished apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, without affecting potassium efflux, in a mouse macrophage cell line (J774), mouse bone marrow-derived dendritic cells, mouse neutrophils, and human PBMCs.	Ethanol	13-20	interleukin 1 beta	Mus musculus	108-116
27421477-5	2016	Ethanol treatment markedly decreased cellular tyrosine phosphorylation, whereas administration of the tyrosine phosphatase inhibitor sodium orthovanadate prior to ethanol restored tyrosine phosphorylation and IL-1beta secretion subsequent to ATP stimulation.	Sodium orthovanadate	133-153	interleukin 1 beta	Mus musculus	209-217
27421477-5	2016	Ethanol treatment markedly decreased cellular tyrosine phosphorylation, whereas administration of the tyrosine phosphatase inhibitor sodium orthovanadate prior to ethanol restored tyrosine phosphorylation and IL-1beta secretion subsequent to ATP stimulation.	Tyrosine	102-110	interleukin 1 beta	Mus musculus	209-217
27387396-14	2016	The expressions of MPO and MMP-9 and the mRNA levels of pro-inflammatory cytokines (IL-1beta, IL-6 and IL-12p35) in colonic tissue significantly decreased after MQEQ treatment.	mqeq	161-165	interleukin 1 beta	Mus musculus	84-92
27178899-4	2016	Our present results indicate that in respect of inhibition of IL-1beta-dependent iNOS induction, betaTC6 cells are more sensitive to EMK 1071 (2-((5-methylthiophen-2-yl)methylene)malononitrile) and EMK 31 (2-(4-hydroxy-3-methoxybenzylidene)malononitrile) as compared to other analyzed AMN compounds.	2-((5-methylthiophen-2-yl)methylene)malononitrile	143-192	interleukin 1 beta	Mus musculus	62-70
27178899-4	2016	Our present results indicate that in respect of inhibition of IL-1beta-dependent iNOS induction, betaTC6 cells are more sensitive to EMK 1071 (2-((5-methylthiophen-2-yl)methylene)malononitrile) and EMK 31 (2-(4-hydroxy-3-methoxybenzylidene)malononitrile) as compared to other analyzed AMN compounds.	2-[(4-hydroxy-3-methoxyphenyl)methylidene]propanedinitrile	206-253	interleukin 1 beta	Mus musculus	62-70
27301359-3	2016	Herein, we show that hyaluronan (HA) oligomer, HA tetrasaccharide (HA4), could suppress the expression of proinflammatory cytokine IL-1beta when stimulated with both TLR2- and TLR4-specific agonists in primary hippocampal neurons.	Hyaluronic Acid	21-31	interleukin 1 beta	Mus musculus	131-139
27301359-3	2016	Herein, we show that hyaluronan (HA) oligomer, HA tetrasaccharide (HA4), could suppress the expression of proinflammatory cytokine IL-1beta when stimulated with both TLR2- and TLR4-specific agonists in primary hippocampal neurons.	ha tetrasaccharide	47-65	interleukin 1 beta	Mus musculus	131-139
26928197-6	2016	Treatment of ovariectomized (OVX) mice with inflammasome inhibitor VX-765 ameliorated depression- and anxiety-like behavior and reversed increased levels of IL-1beta and IL-18 in hippocampus.	belnacasan	67-73	interleukin 1 beta	Mus musculus	157-165
27301359-3	2016	Herein, we show that hyaluronan (HA) oligomer, HA tetrasaccharide (HA4), could suppress the expression of proinflammatory cytokine IL-1beta when stimulated with both TLR2- and TLR4-specific agonists in primary hippocampal neurons.	ha4	67-70	interleukin 1 beta	Mus musculus	131-139
26867125-6	2016	Administration of gabapentin or tramadol reversed significantly the increase in the concentration of IL-1beta induced by PSNL after either 7 or 14 days and their combination was significantly more potent in reversing the elevated concentration of IL-1beta.	Gabapentin	18-28	interleukin 1 beta	Mus musculus	101-109
26867125-6	2016	Administration of gabapentin or tramadol reversed significantly the increase in the concentration of IL-1beta induced by PSNL after either 7 or 14 days and their combination was significantly more potent in reversing the elevated concentration of IL-1beta.	Gabapentin	18-28	interleukin 1 beta	Mus musculus	247-255
26867125-6	2016	Administration of gabapentin or tramadol reversed significantly the increase in the concentration of IL-1beta induced by PSNL after either 7 or 14 days and their combination was significantly more potent in reversing the elevated concentration of IL-1beta.	Tramadol	32-40	interleukin 1 beta	Mus musculus	101-109
26867125-6	2016	Administration of gabapentin or tramadol reversed significantly the increase in the concentration of IL-1beta induced by PSNL after either 7 or 14 days and their combination was significantly more potent in reversing the elevated concentration of IL-1beta.	Tramadol	32-40	interleukin 1 beta	Mus musculus	247-255
26867125-8	2016	Gabapentin or tramadol or their combination modulates the expression of pro-inflammatory cytokine, IL-1beta, in a model of mice PSNL which could be due to an inhibition of glial function.	Gabapentin	0-10	interleukin 1 beta	Mus musculus	99-107
26867125-8	2016	Gabapentin or tramadol or their combination modulates the expression of pro-inflammatory cytokine, IL-1beta, in a model of mice PSNL which could be due to an inhibition of glial function.	Tramadol	14-22	interleukin 1 beta	Mus musculus	99-107
27527191-7	2016	Moreover, the algal meroterpene decreased the tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-10 levels, and caused a significant reduction of the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).	meroterpene	20-31	interleukin 1 beta	Mus musculus	81-103
27446282-9	2016	In the present study, curcumin demonstrated marked suppression of the LPS-induced expression of MyD88, NF-kappaB, caspase-3, inducible nitric oxide synthase, tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 in the microglia.	Curcumin	22-30	interleukin 1 beta	Mus musculus	187-209
27300306-8	2016	Real time PCR and quantitative PCR analysis revealed that AOM/DSS colitis tissues expressed up-regulated IL-1beta, IL-33, TGF-beta, and EGF mRNA.	Dextran Sulfate	62-65	interleukin 1 beta	Mus musculus	105-113
27418552-6	2016	IL-1beta-mediated stimulation of mouse PA-SMC growth was abolished by anakinra and absent in IL-1R1(-/-) and MyD88(-/-) mice.	pa-smc	39-45	interleukin 1 beta	Mus musculus	0-8
27423466-6	2016	SFN further attenuated IL-1beta secretion of monosodium uric acid-induced peritonitis in mice.	monosodium uric acid	45-65	interleukin 1 beta	Mus musculus	23-31
27031380-11	2016	MEASUREMENTS AND MAIN RESULTS: Trametinib inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase signaling 6 hours after cecal ligation and puncture attenuated increases in circulating proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and granulocyte macrophage colony-stimulating factor) and hypothermia at 18 hours.	trametinib	31-41	interleukin 1 beta	Mus musculus	271-288
26911702-10	2016	In mouse mammary tissue, BPA exposure in utero significantly decreased the expression of members of the chemokine CXC family (Cxcl2, Cxcl4, Cxcl14, and Ccl20), interleukin 1 (Il1) gene family (Il1beta and Il1rn), interleukin 2 gene family (Il7 receptor), and interferon gene family (interferon regulatory factor 9 (Irf9), as well as immune response gene 1 (Irg1).	bisphenol A	25-28	interleukin 1 beta	Mus musculus	193-200
27043748-4	2016	The results showed that geraniin inhibited CP-induced kidney histopathologic changes, MDA, inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production in kidney tissues.	Geraniin	24-32	interleukin 1 beta	Mus musculus	158-175
27043748-4	2016	The results showed that geraniin inhibited CP-induced kidney histopathologic changes, MDA, inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production in kidney tissues.	Geraniin	24-32	interleukin 1 beta	Mus musculus	177-185
27138362-5	2016	Our results showed that isorhamnetin markedly decreased TNF-alpha, IL-1beta, and IL-6 concentrations and suppressed the activation of NF-kappaB signaling.	3-methylquercetin	24-36	interleukin 1 beta	Mus musculus	67-75
27251848-0	2016	GSK2656157, a PERK inhibitor, reduced LPS-induced IL-1beta production through inhibiting Caspase 1 activation in macrophage-like J774.1 cells.	GSK2656157	0-10	interleukin 1 beta	Mus musculus	50-58
27192986-10	2016	Neuroinflammation was significantly reduced by SPB pretreatment in LPS-treated mice as evident from reduction in proinflammatory cytokines (IL-1beta and TNF-alpha).	4-phenylbutyric acid	47-50	interleukin 1 beta	Mus musculus	140-148
27251848-5	2016	Then, focusing on endoplasmic reticulum (ER) stress response among stress responses induced by a large amount of LPS, when GSK2656157, a PERK inhibitor, was used for inhibition of ER stress, GSK2656157 reduced IL-1beta production dose-dependently.	GSK2656157	123-133	interleukin 1 beta	Mus musculus	210-218
27251848-5	2016	Then, focusing on endoplasmic reticulum (ER) stress response among stress responses induced by a large amount of LPS, when GSK2656157, a PERK inhibitor, was used for inhibition of ER stress, GSK2656157 reduced IL-1beta production dose-dependently.	GSK2656157	191-201	interleukin 1 beta	Mus musculus	210-218
27251848-6	2016	Next, when Thapsigargin, an ER stress reagent, was added with LPS, IL-1beta production increased more than by LPS alone.	Thapsigargin	11-23	interleukin 1 beta	Mus musculus	67-75
27251848-10	2016	Therefore, it was found that GSK2656157 specifically inhibited ER stress induced by large amount of LPS and reduced LPS-induced IL-1beta production through inhibition of Caspase 1 activation.	GSK2656157	29-39	interleukin 1 beta	Mus musculus	128-136
26956118-5	2016	Furthermore, resveratrol pretreatment inhibited PMA-induced expressions of macrophage surface markers (CD11b, CD14, and CD36) and PMA-induced NF-kappaB transcriptional activation and, thus, suppressed the secretions of proinflammatory cytokines (TNF-alpha, IL-1beta, and IL-6).	Resveratrol	13-24	interleukin 1 beta	Mus musculus	257-265
27351430-4	2016	Moreover, 1,8-cineol efficiently decreased the level of IL-4, IL-5, IL-10, and MCP-1 in nasal lavage fluids and the level of IL-1beta, IL-6, TNF-alpha, and IFN-gamma in lung tissues of mice infected with influenza virus.	Eucalyptol	10-20	interleukin 1 beta	Mus musculus	125-133
27314211-8	2016	LOME significantly inhibited the production of NO, PGE2, interleukin (IL)-6, IL-1beta, and tumor necrosis factor-alpha (TNF-alpha) in LPS-stimulated RAW264.7 cells.	lome	0-4	interleukin 1 beta	Mus musculus	77-85
27465336-9	2016	Furthermore, prophylactic administration of telmisartan markedly inhibited BBB impairment, NLRP3, apoptotic speck-containing protein (ASC) and Caspase-1 activation, as well as IL-1beta and IL-18 maturation, subsequently improved the neurological outcomes.	Telmisartan	44-55	interleukin 1 beta	Mus musculus	176-184
27465336-10	2016	In conclusion, telmisartan can reduce traumatic cerebral edema by inhibiting the NLRP3 inflammasome-regulated IL-1beta and IL-18 accumulation.	Telmisartan	15-26	interleukin 1 beta	Mus musculus	110-118
26976669-0	2016	Fluoxetine protects against IL-1beta-induced neuronal apoptosis via downregulation of p53.	Fluoxetine	0-10	interleukin 1 beta	Mus musculus	28-36
26976669-4	2016	with twice injections at 1 h and 12 h after transient middle cerebral artery occlusion (tMCAO) respectively alleviated neurological deficits and neuronal apoptosis in a mouse ischemic stroke model, accompanied by inhibiting interleukin-1beta (IL-1beta), Bax and p53 expression and upregulating anti-apoptotic protein Bcl-2 level.	tmcao	88-93	interleukin 1 beta	Mus musculus	224-241
27044662-7	2016	In addition, in NSCs from IL-1beta deficient mice, DHA significantly increased proliferation without effects on p-P38 MAPK, suggesting effects of DHA are mediated via alternative signalling pathways.	dehydroacetic acid	51-54	interleukin 1 beta	Mus musculus	26-34
26976669-4	2016	with twice injections at 1 h and 12 h after transient middle cerebral artery occlusion (tMCAO) respectively alleviated neurological deficits and neuronal apoptosis in a mouse ischemic stroke model, accompanied by inhibiting interleukin-1beta (IL-1beta), Bax and p53 expression and upregulating anti-apoptotic protein Bcl-2 level.	tmcao	88-93	interleukin 1 beta	Mus musculus	243-251
26976669-5	2016	We next mimicked neuroinflammation in ischemic stroke with IL-1beta in primary cultured cortical neurons and found that pretreatment with fluoxetine (1 muM) prevented IL-1beta-induced neuronal apoptosis and upregulation of p53 expression.	Fluoxetine	138-148	interleukin 1 beta	Mus musculus	59-67
27318135-6	2016	Resveratrol also reduced interleukin-1beta and tumor necrosis factor-alpha protein levels and immunoglobulin G extravasation in the brain.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	25-74
27161367-8	2016	In addition, treatment of experimental stroke mice with isorhamnetin suppressed activity of MPO (a biomarker of neutrophil infiltration) and reduced protein levels of IL-1beta, IL-6, and TNF-alpha in ipsilateral cortex.	3-methylquercetin	56-68	interleukin 1 beta	Mus musculus	167-175
26976669-5	2016	We next mimicked neuroinflammation in ischemic stroke with IL-1beta in primary cultured cortical neurons and found that pretreatment with fluoxetine (1 muM) prevented IL-1beta-induced neuronal apoptosis and upregulation of p53 expression.	Fluoxetine	138-148	interleukin 1 beta	Mus musculus	167-175
26976669-6	2016	Furthermore, we demonstrated that p53 overexpression in N2a cell line abolished the anti-apoptotic effect of fluoxetine, indicating that p53 downregulation is required for the protective role of fluoxetine in IL-1beta-induced neuronal apoptosis.	Fluoxetine	109-119	interleukin 1 beta	Mus musculus	209-217
26976669-6	2016	Furthermore, we demonstrated that p53 overexpression in N2a cell line abolished the anti-apoptotic effect of fluoxetine, indicating that p53 downregulation is required for the protective role of fluoxetine in IL-1beta-induced neuronal apoptosis.	Fluoxetine	195-205	interleukin 1 beta	Mus musculus	209-217
26976669-8	2016	Collectively, our findings have revealed that fluoxetine protects against IL-1beta-induced neuronal apoptosis via p38-p53 dependent pathway, which give us an insight into the potential of fluoxetine in terms of opening up novel therapeutic avenues for neurological diseases including stroke.	Fluoxetine	46-56	interleukin 1 beta	Mus musculus	74-82
26976669-8	2016	Collectively, our findings have revealed that fluoxetine protects against IL-1beta-induced neuronal apoptosis via p38-p53 dependent pathway, which give us an insight into the potential of fluoxetine in terms of opening up novel therapeutic avenues for neurological diseases including stroke.	Fluoxetine	188-198	interleukin 1 beta	Mus musculus	74-82
27472313-10	2016	Taken together, these results suggest that corynoline reduces the levels of pro-inflammatory mediators, such as iNOS, COX-2, TNF-alpha and IL-1beta, by suppressing extracellular signal-regulated kinase 1/2 (ERK) and p38 phosphorylation in RAW264.7 cells, which is regulated by the Nrf2/ARE pathway.	corynoline	43-53	interleukin 1 beta	Mus musculus	139-147
27498833-5	2016	The flavone 7,4"-di-O-methylisoscutellarein showed anti-inflammatory activity by inhibiting neutrophils recruitment in a mice model of pleurisy and by decreasing significantly the production of cytokines IL-1beta and TNF-alpha.	flavone	4-11	interleukin 1 beta	Mus musculus	204-212
27498833-5	2016	The flavone 7,4"-di-O-methylisoscutellarein showed anti-inflammatory activity by inhibiting neutrophils recruitment in a mice model of pleurisy and by decreasing significantly the production of cytokines IL-1beta and TNF-alpha.	7,4'-di-O-methylisoscutellarein	12-43	interleukin 1 beta	Mus musculus	204-212
26918466-6	2016	In saline-treated mice fed control diet, aging increased the proportion of microglia that stained for MHC class II (&lt;3% for adults vs. 23% for aged), IL-1beta (&lt;2% for adults vs. 25% for aged), and IL-6 (&lt;2% for adults vs. 25% for aged), indicating an age-related increase in proinflammatory microglia.	Sodium Chloride	3-9	interleukin 1 beta	Mus musculus	153-161
26918466-7	2016	In saline-treated aged mice fed luteolin, the proportion of microglia that stained for MHC class II, IL-1beta, and IL-6 was reduced by nearly half (to 12%, 13%, and 12%, respectively).	Sodium Chloride	3-9	interleukin 1 beta	Mus musculus	101-109
27133574-8	2016	Thus, the present study provides direct evidence that accumulated IL-1beta contributed to the diazepam refractoriness of prolonged SE, and suggests that interleukin-1 receptor is a target for adjunctive control of diazepam-refractory SE.	Diazepam	94-102	interleukin 1 beta	Mus musculus	66-74
27216632-5	2016	TiO2NPs induced IL-1beta in the three cell lines and IL-6 in N2a.	tio2nps	0-7	interleukin 1 beta	Mus musculus	16-24
27133574-8	2016	Thus, the present study provides direct evidence that accumulated IL-1beta contributed to the diazepam refractoriness of prolonged SE, and suggests that interleukin-1 receptor is a target for adjunctive control of diazepam-refractory SE.	Diazepam	214-222	interleukin 1 beta	Mus musculus	66-74
27113683-4	2016	Enzyme-linked immunosorbent assay (ELISA) revealed that treatment with liquiritigenin significantly reduced the concentrations of pro-inflammatory cytokines including interleukin (IL)-6, IL-1beta and tumor necrosis factor (TNF)-alpha in serum and hippocampus.	liquiritigenin	71-85	interleukin 1 beta	Mus musculus	187-195
27401148-10	2016	Furthermore, MEK inhibitor (PD98059) attenuated mechanical allodynia and reduced TNF-alpha and IL-1beta upregulation induced by pIONL.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	28-35	interleukin 1 beta	Mus musculus	95-103
27157410-11	2016	In vitro, COV08-0064 selectively blocked mRNA upregulation of TNF-alpha, IL-1beta, NLRP3 and MCP-1 in macrophages and IFN-beta mRNA in dendritic cells induced by the TLR9 agonist CpG-ODN.	6-N-methylnaltrexamine	10-20	interleukin 1 beta	Mus musculus	73-81
27401148-13	2016	Pretreatment with PD98059, Etanercept, or Diacerein partially blocked CXCL13-induced mechanical allodynia, and PD98059 also reduced CXCL13-induced TNF-alpha and IL-1beta upregulation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	111-118	interleukin 1 beta	Mus musculus	161-169
27184504-5	2016	Furthermore, protein and mRNA levels of pro-inflammatory cytokines, including IL-1beta, TNF-alpha and IL-6 were markedly suppressed by DMF.	Dimethyl Fumarate	135-138	interleukin 1 beta	Mus musculus	78-86
27155455-7	2016	Additionally, ST2825 significantly reduced the levels of Iba-1 and inflammatory factors TNF-alpha and IL-1beta.	ST2825	14-20	interleukin 1 beta	Mus musculus	102-110
27401148-11	2016	TNF-alpha inhibitor (Etanercept) and IL-1beta inhibitor (Diacerein) attenuated pIONL-induced orofacial pain.	diacerein	57-66	interleukin 1 beta	Mus musculus	37-45
27401148-11	2016	TNF-alpha inhibitor (Etanercept) and IL-1beta inhibitor (Diacerein) attenuated pIONL-induced orofacial pain.	pionl	79-84	interleukin 1 beta	Mus musculus	37-45
27151938-8	2016	Further studies showed significantly higher TNF-alpha and IL-1beta mRNA, a marked increase in total and phosphorylated-p65 and phosphorylated IkappaBalpha (degradation form) in livers of DEN-treated 0.2% CA-fed mice.	Diethylnitrosamine	187-190	interleukin 1 beta	Mus musculus	58-66
27388564-12	2016	In addition, LTD4 and PGE2 treatment significantly elevated the plasma levels of cysteinyl leukotrienes and PGE2, as well as levels of IL-1beta, IL-2, IL-6, TNF-alpha and CXCL1/KC/GRO.	Dinoprostone	22-26	interleukin 1 beta	Mus musculus	135-143
27388564-13	2016	In addition, increased mRNA expression of IL-1beta, IL-6 and IL-10 were detected in tumors from mice that had been treated with LTD4 or PGE2.	Leukotriene D4	128-132	interleukin 1 beta	Mus musculus	42-50
27388564-13	2016	In addition, increased mRNA expression of IL-1beta, IL-6 and IL-10 were detected in tumors from mice that had been treated with LTD4 or PGE2.	Dinoprostone	136-140	interleukin 1 beta	Mus musculus	42-50
27170516-6	2016	Furthermore, sacran significantly suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema and mRNA expression levels of cyclooxygenase (COX)-2 as well as pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6.	sacran	13-19	interleukin 1 beta	Mus musculus	246-268
27023766-11	2016	Mice anesthetized with isoflurane and sevoflurane showed thinner alveolar septa, lower VILI scores, lower polymorph neutrophil counts, and lower interleukin-1beta concentrations than ketamine mice.	Isoflurane	23-33	interleukin 1 beta	Mus musculus	145-162
27023766-11	2016	Mice anesthetized with isoflurane and sevoflurane showed thinner alveolar septa, lower VILI scores, lower polymorph neutrophil counts, and lower interleukin-1beta concentrations than ketamine mice.	Sevoflurane	38-49	interleukin 1 beta	Mus musculus	145-162
27170516-6	2016	Furthermore, sacran significantly suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema and mRNA expression levels of cyclooxygenase (COX)-2 as well as pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6.	Tetradecanoylphorbol Acetate	45-81	interleukin 1 beta	Mus musculus	246-268
27261579-8	2016	Finally, though GB and GM at equivalent dosages appear to reduce LPS-induced IL-1beta mRNA and protein levels and IL-10 protein levels to the same degree, GM is more potent than GB to attenuate the IL-10 mRNA levels.	ginkgolide B	16-18	interleukin 1 beta	Mus musculus	77-85
27170516-6	2016	Furthermore, sacran significantly suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema and mRNA expression levels of cyclooxygenase (COX)-2 as well as pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6.	Tetradecanoylphorbol Acetate	83-86	interleukin 1 beta	Mus musculus	246-268
27179450-7	2016	Compared with the model group, the accumulation of MPO activity, the colonic tissue levels of IL-1beta, IFN-gamma and TNF-alpha were significantly reduced in the tauroursodeoxycholate treated groups.	ursodoxicoltaurine	162-183	interleukin 1 beta	Mus musculus	94-102
27261579-8	2016	Finally, though GB and GM at equivalent dosages appear to reduce LPS-induced IL-1beta mRNA and protein levels and IL-10 protein levels to the same degree, GM is more potent than GB to attenuate the IL-10 mRNA levels.	gm	23-25	interleukin 1 beta	Mus musculus	77-85
26626290-8	2016	DISCUSSION: Cromakalim suppresses morphine-induced astrocyte activation significantly by suppressing the c-Jun N-terminal kinase pathway, resulting in a reduced release of interleukin-1beta and the attenuation of morphine chronic antinociceptive tolerance.	Cromakalim	12-22	interleukin 1 beta	Mus musculus	172-189
27219527-10	2016	The trillin-treated group exhibited reduced AST, ALT, MDA, IL-6, TNF-alpha, and IL-1beta, and increased SOD.	diosgenin glucoside	4-11	interleukin 1 beta	Mus musculus	80-88
27135544-8	2016	Suppression of MyD88 by ST2825 eliminated the inhibitory effects of dioscin on the levels of IRAK1, TRAF6, p-IKK, p-IkappaBalpha, p-NF-kappaB p65, HMGB-1, IL-1beta, IL-6 and TNF-alpha.	ST2825	24-30	interleukin 1 beta	Mus musculus	155-163
27135544-8	2016	Suppression of MyD88 by ST2825 eliminated the inhibitory effects of dioscin on the levels of IRAK1, TRAF6, p-IKK, p-IkappaBalpha, p-NF-kappaB p65, HMGB-1, IL-1beta, IL-6 and TNF-alpha.	dioscin	68-75	interleukin 1 beta	Mus musculus	155-163
27261622-8	2016	Furthermore, the activity accumulation of MPO and the colonic tissue levels of IL-1beta, IFN-gamma and TNF-alpha were also decreased by administration of taurocholate.	Taurocholic Acid	154-166	interleukin 1 beta	Mus musculus	79-87
27103568-7	2016	D-allose also repressed the levels of TNF-alpha, NF-kappaB, interleukin (IL)-1beta and IL-8 in inflammatory responses.	allose	0-8	interleukin 1 beta	Mus musculus	60-82
27191349-7	2016	Oxalate crystals have been shown to activate the NOD-like receptor family, pyrin domain containing 3 inflammasome (also known as NALP3, NLRP3, or cryopyrin), resulting in release of IL-1beta and macrophage infiltration.	Oxalates	0-7	interleukin 1 beta	Mus musculus	182-190
26862745-7	2016	Activation of AhR by TCDD caused a significant increase of the inflammatory cytokines Interleukin (IL)-1beta, IL-6 and IL-10, and CXCL chemokines in white epididymal adipose tissue from both wt and AhRR Tg mice.	Polychlorinated Dibenzodioxins	21-25	interleukin 1 beta	Mus musculus	86-108
26862745-8	2016	However, the expression of IL-1beta, CXCL2 and CXCL3 were significantly lower in AhRR Tg versus wt mice following TCDD treatment.	Polychlorinated Dibenzodioxins	114-118	interleukin 1 beta	Mus musculus	27-35
27260463-4	2016	We found that naringenin reduced hyperalgesia to mechanical and thermal stimuli, myeloperoxidase (MPO, a neutrophil and macrophage marker) and N-acetyl-beta-D-glucosaminidase (NAG, a macrophage marker) activities, oxidative stress and cytokine (TNF-alpha, IL-1beta, IL-6, and IL-12) production in the paw skin.	naringenin	14-24	interleukin 1 beta	Mus musculus	256-264
27042761-7	2016	Additionally, it was noted that the levels of IL-1beta, IL-8 and MCP-1 were enhanced in the blood of mice exposed to both types of AlO NP and the percentages of neutrophils and monocytes among all white blood cells were increased only in mice injected with the long-type AlO NP (5 mg/kg).	alo np	131-137	interleukin 1 beta	Mus musculus	46-54
27260463-6	2016	In vitro, pre-treatment with naringenin inhibited superoxide anion and cytokine (TNF-alpha, IL-1beta, IL-6, and IL-12) production by LPS-stimulated RAW 264.7 macrophages.	naringenin	29-39	interleukin 1 beta	Mus musculus	92-100
27382358-3	2016	It was found berberine concentration-dependently induced the expressions of ATF-3 at the mRNA and protein levels and concomitantly suppressed the LPS-induced productions of proinflammatory cytokines (TNF-alpha, IL-6, and IL-1beta).	Berberine	13-22	interleukin 1 beta	Mus musculus	221-229
27189966-3	2016	AEA (100 muM) inhibited Hcys-induced NLRP3 inflammasome activation in cultured podocytes, as indicated by elevated caspase-1 activity and interleukin-1beta levels, and attenuated podocyte dysfunction, as shown by reduced vascular endothelial growth factor production.	anandamide	0-3	interleukin 1 beta	Mus musculus	138-155
27189966-3	2016	AEA (100 muM) inhibited Hcys-induced NLRP3 inflammasome activation in cultured podocytes, as indicated by elevated caspase-1 activity and interleukin-1beta levels, and attenuated podocyte dysfunction, as shown by reduced vascular endothelial growth factor production.	Homocysteine	24-28	interleukin 1 beta	Mus musculus	138-155
27189966-5	2016	In mice in vivo, AEA treatment attenuated glomerular NLRP3 inflammasome activation induced by hHcys accompanying a folate-free diet, on the basis of inhibition of hHcys-induced colocalization of NLRP3 molecules and increased interleukin-1beta levels in glomeruli.	anandamide	17-20	interleukin 1 beta	Mus musculus	225-242
27270404-8	2016	Interleukin-1beta and IL-6 were increased in arthritic CO-fed mice compared to NA mice but were reduced in 0.5 % c9t11-CLA- and EB-fed mice through day 42.	Linoleic Acids, Conjugated	119-122	interleukin 1 beta	Mus musculus	0-17
27270404-8	2016	Interleukin-1beta and IL-6 were increased in arthritic CO-fed mice compared to NA mice but were reduced in 0.5 % c9t11-CLA- and EB-fed mice through day 42.	ethylbenzene	128-130	interleukin 1 beta	Mus musculus	0-17
27322427-3	2016	In the present study, we first demonstrated that in mice infected with Schistosoma J. for 6 weeks exhibited increased levels of IL-1beta in liver, a major product of NLRP3 inflammasomes and collagen deposition around the eosinophilic granuloma with Schistosoma J. eggs, which was substantially attenuated by caspase-1 inhibitor, YVAD.	YVAD	329-333	interleukin 1 beta	Mus musculus	128-136
26961887-3	2016	Our results revealed that non-toxic concentrations (6.25-25 muM) of DDA markedly suppressed LPS-induced production of nitric oxide, expression of inducible nitric oxide synthase and cyclooxygenase-2, and release of inflammatory factors, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 in a concentration dependent manner.	dda	68-71	interleukin 1 beta	Mus musculus	282-304
27222119-5	2016	Daidzein had an anti-inflammatory effect by inhibiting tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta) and nuclear factor kappaB (NF-kappaB) protein expression.	daidzein	0-8	interleukin 1 beta	Mus musculus	96-113
27222119-5	2016	Daidzein had an anti-inflammatory effect by inhibiting tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta) and nuclear factor kappaB (NF-kappaB) protein expression.	daidzein	0-8	interleukin 1 beta	Mus musculus	115-123
27050799-7	2016	Furthermore, OMT administration inhibited the release of inflammatory factors including tumor necrosis factor-alpha, (TNF-alpha) interleukin-1beta (IL-1beta), and interleukin-6 (IL-6), as well as phosphorylated NF-kappaB p65.	oxymatrine	13-16	interleukin 1 beta	Mus musculus	129-146
27050799-7	2016	Furthermore, OMT administration inhibited the release of inflammatory factors including tumor necrosis factor-alpha, (TNF-alpha) interleukin-1beta (IL-1beta), and interleukin-6 (IL-6), as well as phosphorylated NF-kappaB p65.	oxymatrine	13-16	interleukin 1 beta	Mus musculus	148-156
27244892-5	2016	In addition, we found the activation of TREM-1 could significantly enhance the secretion of IL-1beta by TAM in vitro.	tam	104-107	interleukin 1 beta	Mus musculus	92-100
27351842-7	2016	PGE2 increased Il6, Il1b, Il23 and Ccr7 mRNA while reducing Tnfa mRNA through EP4 in isolated myeloid cells.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	20-24
27446078-4	2016	The level of IL-1beta, IL-10, IFNgamma, and TNFalpha in the blood increased within 24 h after the single GC administration to mice.	Glycoconjugates	105-107	interleukin 1 beta	Mus musculus	13-21
27446078-8	2016	The addition of aluminum hydroxide to GC stimulated the production of GM-CSF, IL-1beta, IL-5, IL-6, IL-10, IL-17, IFNgamma, and TNFalpha.	Aluminum Hydroxide	16-34	interleukin 1 beta	Mus musculus	78-86
27446078-8	2016	The addition of aluminum hydroxide to GC stimulated the production of GM-CSF, IL-1beta, IL-5, IL-6, IL-10, IL-17, IFNgamma, and TNFalpha.	Glycoconjugates	38-40	interleukin 1 beta	Mus musculus	78-86
27321991-7	2016	The results showed that alpinetin significantly attenuated diarrhea, colonic shortening, histological injury, myeloperoxidase (MPO) activity and the expressions of tumor necrosis factor (TNF-alpha) and interleukin (IL-1beta) production in mice.	alpinetin	24-33	interleukin 1 beta	Mus musculus	215-223
27321991-8	2016	In vitro, alpinetin markedly inhibited LPS-induced TNF-alpha and IL-1beta production, as well as Toll-like receptor 4 (TLR4) mediated nuclear transcription factor-kappaB (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasome activation.	alpinetin	10-19	interleukin 1 beta	Mus musculus	65-73
27235713-14	2016	RESULTS: LPPI was not toxic to uninfected macrophages (pMO) and significantly increased mRNA expression of TNF-alpha, IL-6, IL-1beta and iNOS.	lppi	9-13	interleukin 1 beta	Mus musculus	124-132
27060662-7	2016	Bilirubin accumulates in brain tissue from hUGT1/Ikkbeta(DeltaIEC) mice inducing an inflammatory state as shown by elevated TNFalpha, IL-1beta and IL-6, all of which can be prevented by neonatal induction of hepatic or intestinal UGT1A1 and lowering of TSB levels.	Bilirubin	0-9	interleukin 1 beta	Mus musculus	134-142
27272194-9	2016	In the formalin test, DHC decreased the expression of caspase 6 (CASP6), TNF-alpha, IL-1beta and IL-6 proteins in the spinal cord.	dehydrocorydalin	22-25	interleukin 1 beta	Mus musculus	84-92
27282478-12	2016	This protective effect of CQ was associated with a reduced expression of the inflammatory mediators interleukin-1beta, interleukin-6, and cyclooxygenase-2, while the levels of matrix metalloproteinases-2 and -9 were not modified.	Chloroquine	26-28	interleukin 1 beta	Mus musculus	100-117
27260322-9	2016	RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta.	Curcumin	14-22	interleukin 1 beta	Mus musculus	121-129
26921756-4	2016	The results showed that wogonoside inhibited the production of serum Alanine transaminase (ALT), Aspartate aminotransferase (AST), IL-1beta, TNF-alpha, and hepatic malondialdehyde (MDA) content induced by LPS/GalN.	wogonoside	24-34	interleukin 1 beta	Mus musculus	131-139
26921756-6	2016	Wogonoside inhibited the expression of hepatic NLRP3, ASC, caspase-1, and IL-1beta induced by LPS/GalN.	wogonoside	0-10	interleukin 1 beta	Mus musculus	74-82
26976763-10	2016	RESULTS: HLJDE could significantly suppress the secretion of NO, IL-1beta, IL-4, MCP-1 and GM-CSF in RAW264.7 cells in a dose-dependent manner.	hljde	9-14	interleukin 1 beta	Mus musculus	65-73
27001378-6	2016	Regarding mechanism, AS2677131 regulated DNA binding activity of c-Rel on IL-12p40 and IL-1beta promoter.	as2677131	21-30	interleukin 1 beta	Mus musculus	87-95
27260322-9	2016	RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta.	Curcumin	14-22	interleukin 1 beta	Mus musculus	324-332
27260322-9	2016	RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta.	Curcumin	55-63	interleukin 1 beta	Mus musculus	121-129
27260322-9	2016	RESULTS: Both curcumin and nanoparticles encapsulating curcumin suppressed mRNA expression of pro-inflammatory mediators IL-1beta and TNF-alpha, MMPs 1, 3, and 13, and aggrecanase ADAMTS5, and upregulated the chondroprotective transcriptional regulator CITED2, in primary cultured chondrocytes in the absence or presence of IL-1beta.	Curcumin	55-63	interleukin 1 beta	Mus musculus	324-332
27085138-6	2016	Compared with that of STZ-treated WT mice, the wound granulation tissue of STZ-treated VEGFR1 TK(-/-) mice contained more VEGFR1-positive cells expressing IL-1beta [a classic (M1) activated macrophage marker] and fewer VEGFR1-positive cells expressing the mannose receptor [CD206; an alternatively activated (M2) macrophage marker].	Streptozocin	75-78	interleukin 1 beta	Mus musculus	155-163
27070821-7	2016	Similarly in mouse keratinocytes in vitro, corticosterone dose dependently suppressed 2,4,6-trinitrobenzenesulfonic acid-induced IL-1alpha and IL-1beta expression.	Corticosterone	43-57	interleukin 1 beta	Mus musculus	143-151
27070821-7	2016	Similarly in mouse keratinocytes in vitro, corticosterone dose dependently suppressed 2,4,6-trinitrobenzenesulfonic acid-induced IL-1alpha and IL-1beta expression.	Trinitrobenzenesulfonic Acid	86-120	interleukin 1 beta	Mus musculus	143-151
27085138-7	2016	Treatment of STZ-treated VEGFR1 TK(-/-) mice with an IL-1beta-neutralizing antibody restored impaired wound healing and angiogenesis/lymphangiogenesis and induced macrophages in the wound granulation tissue to switch to an M2 phenotype.	Streptozocin	13-16	interleukin 1 beta	Mus musculus	53-61
27070821-10	2016	Taken together, these data suggest that corticosterone activation by 11beta-HSD1 in keratinocytes suppresses hapten-induced irritant dermatitis through suppression of expression of cytokines, such as IL-1alpha and IL-1beta, in keratinocytes.	Corticosterone	40-54	interleukin 1 beta	Mus musculus	214-222
27332074-7	2016	Furthermore, UA significantly suppressed the upregulation of IL-1beta, IL-6, and tumor necrosis-alpha factor levels in the hippocampus of Abeta25-35-treated mice.	ursolic acid	13-15	interleukin 1 beta	Mus musculus	61-69
27330276-8	2016	Use of BAY 11-7082, an inhibitor of nuclear factor-kappaB (NF-kappaB), led to significantly suppressing effects on IL-1beta and TNF-alpha expression similar as that of GS-treated cells.	3-(4-methylphenylsulfonyl)-2-propenenitrile	7-18	interleukin 1 beta	Mus musculus	115-123
27233783-6	2016	On the contrary, overexpression of SOCS1 in the SC reversed CCI-induced pain behavioral, activation of neurons, astrocytes, microglia, and the expression of proinflammatory cytokines including tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta) and IL-6.	CCI	60-63	interleukin 1 beta	Mus musculus	234-251
27233783-6	2016	On the contrary, overexpression of SOCS1 in the SC reversed CCI-induced pain behavioral, activation of neurons, astrocytes, microglia, and the expression of proinflammatory cytokines including tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta) and IL-6.	CCI	60-63	interleukin 1 beta	Mus musculus	253-261
27160222-4	2016	Intraplantar injection of superoxide anion activated NF-kappaB and increased cytokine production (IL-1beta, TNF-alpha and IL-10) and oxidative stress (nitrite and lipid peroxidation levels) at the primary inflammatory foci and in the spinal cord (L4-L6).	Superoxides	26-42	interleukin 1 beta	Mus musculus	98-106
27089391-6	2016	qPCR and ELISA assays demonstrated that plantamajoside suppressed the production of IL-1beta, IL-6 and TNF-alpha in a dose-dependent manner.	plantamajoside	40-54	interleukin 1 beta	Mus musculus	84-92
27039209-7	2016	The ELISA and qRT-PCR results showed that sophocarpine inhibited the expression of TNF-alpha, IL-1beta and IL-6 in a dose-dependent manner.	sophocarpine	42-54	interleukin 1 beta	Mus musculus	94-102
27063951-10	2016	In conclusion, the data suggest that UA promotes macrophage autophagy and, thereby, suppresses IL-1beta secretion, promotes cholesterol efflux, and attenuates atherosclerosis in mice.	ursolic acid	37-39	interleukin 1 beta	Mus musculus	95-103
27327581-9	2016	Both Dex drops and Dex-NW significantly decreased expression of IL-1beta, IL-6, and MMP-9 RNA transcripts compared with vehicle drops or wafers 2 and 5 days after the initial lesion.	Dexamethasone	5-8	interleukin 1 beta	Mus musculus	64-72
26868525-5	2016	Importantly, the accumulation of neutrophils and the amount IL-1beta in the joints were reduced in macrophage migration inhibitory factor-deficient mice when injected with monosodium urate crystals.	Uric Acid	172-188	interleukin 1 beta	Mus musculus	60-68
27251615-3	2016	The receptor is activated by the release of ATP from intracellular sources that occurs during neurodegeneration, leading to microglial activation and inflammasome-mediated interleukin 1beta release that contributes to neuroinflammation.	Adenosine Triphosphate	44-47	interleukin 1 beta	Mus musculus	172-189
27044804-3	2016	In addition, arglabin reduced interleukin-1beta (IL-1beta) production in a concentration-dependent manner in Langerhans islets isolated from ApoE2Ki mice treated with lipopolysaccharide (LPS) and with cholesterol crystals.	arglabin	13-21	interleukin 1 beta	Mus musculus	30-47
27044804-3	2016	In addition, arglabin reduced interleukin-1beta (IL-1beta) production in a concentration-dependent manner in Langerhans islets isolated from ApoE2Ki mice treated with lipopolysaccharide (LPS) and with cholesterol crystals.	arglabin	13-21	interleukin 1 beta	Mus musculus	49-57
27225830-3	2016	Cardiac dysfunction and injury were induced by low-dose Dox (15 mg/kg) administration in NLRP3-deficient (NLRP3(-/-)) mice but not in wild-type (WT) and IL-1beta(-/-) mice, indicating that NLRP3 deficiency enhanced the susceptibility to Dox-induced cardiotoxicity independent of IL-1beta.	Doxorubicin	56-59	interleukin 1 beta	Mus musculus	279-287
27056913-7	2016	In addition, elevated levels of proinflammatory cytokines such as IL-1b, IL-2, and TNF-alpha were observed in diabetes, which were reduced with aminoguanidine treatment, suggesting the involvement of glycation in the immune response.	pimagedine	144-158	interleukin 1 beta	Mus musculus	66-71
27082984-6	2016	The 7-day DSS administration induced marked colon damage, increased the serum levels of IL-1beta and TNF-alpha, increased MDA content and decreased SOD activity in the colon homogenate.	Dextran Sulfate	10-13	interleukin 1 beta	Mus musculus	88-96
26907804-10	2016	The mechanisms of naringenin involve the inhibition of carrageenan-induced oxidative stress, hyperalgesic cytokines (IL-33, TNF-alpha, and IL-1beta) production and NF-kappaB activation in the paw skin.	naringenin	18-28	interleukin 1 beta	Mus musculus	139-147
27058411-10	2016	The alphaENaC mRNA levels and sodium transport were increased in SOCS-1 overexpressing MLE-12 cells exposed to IL-1beta.	Sodium	30-36	interleukin 1 beta	Mus musculus	111-119
27021320-4	2016	Surprisingly, the results showed a drastic reduction in caspase 1 and interleukin-1beta (IL-1beta) cleavage in the livers of mice treated with CFZ for 8 weeks (8-week-CFZ-treated mice) compared to 2-week-CFZ-treated and control mice, which was accompanied by a 3-fold increase in hepatic IL-1 receptor antagonist (IL-1RA) production and a 21-fold increase in serum IL-1RA levels.	Clofazimine	143-146	interleukin 1 beta	Mus musculus	70-87
27021320-4	2016	Surprisingly, the results showed a drastic reduction in caspase 1 and interleukin-1beta (IL-1beta) cleavage in the livers of mice treated with CFZ for 8 weeks (8-week-CFZ-treated mice) compared to 2-week-CFZ-treated and control mice, which was accompanied by a 3-fold increase in hepatic IL-1 receptor antagonist (IL-1RA) production and a 21-fold increase in serum IL-1RA levels.	Clofazimine	143-146	interleukin 1 beta	Mus musculus	89-97
27021320-4	2016	Surprisingly, the results showed a drastic reduction in caspase 1 and interleukin-1beta (IL-1beta) cleavage in the livers of mice treated with CFZ for 8 weeks (8-week-CFZ-treated mice) compared to 2-week-CFZ-treated and control mice, which was accompanied by a 3-fold increase in hepatic IL-1 receptor antagonist (IL-1RA) production and a 21-fold increase in serum IL-1RA levels.	Clofazimine	167-170	interleukin 1 beta	Mus musculus	70-87
27021320-4	2016	Surprisingly, the results showed a drastic reduction in caspase 1 and interleukin-1beta (IL-1beta) cleavage in the livers of mice treated with CFZ for 8 weeks (8-week-CFZ-treated mice) compared to 2-week-CFZ-treated and control mice, which was accompanied by a 3-fold increase in hepatic IL-1 receptor antagonist (IL-1RA) production and a 21-fold increase in serum IL-1RA levels.	Clofazimine	167-170	interleukin 1 beta	Mus musculus	89-97
27195769-6	2016	Less production of tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1ss) was observed in LOX-1 KO mice than WT mice after DOX administration.	Doxorubicin	140-143	interleukin 1 beta	Mus musculus	63-81
27105502-6	2016	Moreover, protein and mRNA levels of DSS-induced proinflammatory cytokines in colon, including TNF, IL-1beta, IL-6, IL-18, IL-17A and IFN-gamma, were markedly suppressed by MALT1 inhibitors.	Dextran Sulfate	37-40	interleukin 1 beta	Mus musculus	100-108
27347331-6	2016	In addition, sesamin inhibited neutrophils infiltration and pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta production in IR-preformed kidney.	sesamin	13-20	interleukin 1 beta	Mus musculus	125-147
27347321-5	2016	The results demonstrated that the ethanol extract from POL could exhibit the effective protection for the DSS induced UC by increasing the colon length, decreasing body weight loss and the disease activity index score, inhibiting oxidative stress response through the MDA, NO, SOD activities, reducing the mRNA expressions of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) and the protein expressions of TNF-alpha and NF-kB p65.	Ethanol	34-41	interleukin 1 beta	Mus musculus	365-373
27016588-4	2016	Although MV-O2 induced larger and fewer alveoli in both, TNF-alpha(-/-) and TNF-alpha(+/+) mice, it caused enhanced lung apoptosis (TUNEL, caspase-3/-6/-8), infiltration of macrophages and neutrophils, and proinflammatory mediator expression (IL-1beta, CXCL-1, MCP-1) in TNF-alpha(-/-) mice.	mv-o2	9-14	interleukin 1 beta	Mus musculus	243-251
27144271-9	2016	In addition, the mRNA levels of pro-inflammatory genes such as TNF-alpha, MCP-1, IL-1beta and IL-6 in the liver were dose-dependently reduced by paeonol pre-treatment.	paeonol	145-152	interleukin 1 beta	Mus musculus	81-89
27171266-4	2016	Decreased mortality by Chtx was associated with reduced hepatic damage, increased peritoneal migration of neutrophils, decreased mRNA expression of IL-1beta as well as inhibition of inflammasome activation in liver.	chitohexaose	23-27	interleukin 1 beta	Mus musculus	148-156
27171266-9	2016	Also, Chtx administration mediated significant reversal of mortality in APAP+LPS co-administered mice, which was associated with reduced IL-1beta in liver and plasma cytokines in this model.	chitohexaose	6-10	interleukin 1 beta	Mus musculus	137-145
27152411-7	2016	IL-1beta (10 ng/mL; 2 hours)-induced endothelial monolayer hyperpermeability was significantly attenuated by melatonin (10 mug/mL; 1 hour), GM6001 (broad spectrum MMP inhibitor; 10 muM; 1 hour), MMP-9 inhibitor-1 (MMP-9 specific inhibitor; 5 nM; 1 hour) or MMP-9 siRNA transfection (48 hours) in vitro.	Melatonin	109-118	interleukin 1 beta	Mus musculus	0-8
27152411-7	2016	IL-1beta (10 ng/mL; 2 hours)-induced endothelial monolayer hyperpermeability was significantly attenuated by melatonin (10 mug/mL; 1 hour), GM6001 (broad spectrum MMP inhibitor; 10 muM; 1 hour), MMP-9 inhibitor-1 (MMP-9 specific inhibitor; 5 nM; 1 hour) or MMP-9 siRNA transfection (48 hours) in vitro.	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	140-146	interleukin 1 beta	Mus musculus	0-8
27152411-8	2016	Melatonin and MMP-9 inhibitor-1 pretreatment attenuated IL-1beta-induced MMP-9 activity, loss of ZO-1 junctional integrity and f-actin stress fiber formation.	Melatonin	0-9	interleukin 1 beta	Mus musculus	56-64
27152706-0	2016	Interleukin-1beta-Targeted Vaccine Improves Glucose Control and beta-Cell Function in a Diabetic KK-Ay Mouse Model.	Glucose	44-51	interleukin 1 beta	Mus musculus	0-17
27152706-4	2016	In this study, we developed an IL-1beta-targeted epitope peptide vaccine adjuvanted with polylactic acid microparticles (1betaEPP) and applied it to a diabetic KK-Ay mouse model.	poly(lactide)	89-104	interleukin 1 beta	Mus musculus	31-39
27152706-7	2016	Moreover, 1betaEPP restored beta-cell mass; inhibited beta-cell apoptosis; decreased the expression of IL-1beta; and interrupted NF-kappaB activation by reducing IKKbeta and pRelA levels.	1betaepp	10-18	interleukin 1 beta	Mus musculus	103-111
26811540-8	2016	Moreover, IL-1beta-induced FGF-2 expression via IL-1RI (type-1 IL-1 receptor), ROS (reactive oxygen species) generation, AMPK (AMP-activated protein kinase), p38 and NF-kappaB (nuclear factor kappaB) pathway has been demonstrated.	Reactive Oxygen Species	79-82	interleukin 1 beta	Mus musculus	10-18
27133055-5	2016	Treatment with 15d-PGJ2 reduced the pathological effects of ConA-induced fulminant hepatitis and significantly reduced the levels of TNF-alpha, IL-1beta and ROS after injection.	15-deoxyprostaglandin J2	15-23	interleukin 1 beta	Mus musculus	144-152
26935421-10	2016	Collectively, these studies provide evidence for a link between inflammation-related IL1beta/IL1R signaling and the development of asbestos-induced malignant mesothelioma.	Asbestos	131-139	interleukin 1 beta	Mus musculus	85-92
26935421-11	2016	Furthermore, these findings provide rationale for chemoprevention strategies targeting IL1beta/IL1R signaling in high-risk, asbestos-exposed populations.	Asbestos	124-132	interleukin 1 beta	Mus musculus	87-94
26650508-8	2016	Administration of at least 3 g/60 kg omega-3 PUFAs was equivalent to omega-3 PUFAs produced in fat-1 mice and resulted in significant increase in the expression of IL-1beta, caspase-3 and IL-18, as seen in Apc(Min/+) x fat-1 mice.	omega-3 pufas	37-50	interleukin 1 beta	Mus musculus	164-172
26953646-5	2016	Mechanistic study showed that resveratrol repressed the expression of pro-inflammatory cytokines, including TNF-alpha, IL-1beta and IL-6, and promoted the expression of anti-inflammatory cytokine IL-10 at the same time, which was further confirmed in a cell model of microglia.	Resveratrol	30-41	interleukin 1 beta	Mus musculus	119-127
26967742-8	2016	In addition, MESNA markedly reduced ethanol-induced lipid peroxidation, myeloperoxidase activity, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and monocyte chemotactic protein-1 levels.	Mesna	13-18	interleukin 1 beta	Mus musculus	127-149
26830216-13	2016	Artemisinin down-regulated protein levels of NLRP3 and caspase 1 and inhibited the increases of IL-1beta and IL-18 messenger RNA expression from Raw 264.7 cells that were stimulated with burn sepsis serum.	artemisinin	0-11	interleukin 1 beta	Mus musculus	96-104
26922677-11	2016	TRPA1 antagonism by HC-030031 reversed the changes in the number of circulating and peritoneal leukocytes in cinnamaldehyde-treated animals, whilst increasing the levels of peritoneal IL-10 and reducing peritoneal IL-1beta.	cinnamaldehyde	109-123	interleukin 1 beta	Mus musculus	214-222
26811540-8	2016	Moreover, IL-1beta-induced FGF-2 expression via IL-1RI (type-1 IL-1 receptor), ROS (reactive oxygen species) generation, AMPK (AMP-activated protein kinase), p38 and NF-kappaB (nuclear factor kappaB) pathway has been demonstrated.	Reactive Oxygen Species	84-107	interleukin 1 beta	Mus musculus	10-18
26811540-9	2016	On the basis of these findings, we conclude that IL-1beta promotes FGF-2 expression in chondrocytes through the ROS/AMPK/p38/NF-kappaB signalling pathway and subsequently increases EPC angiogenesis.	Reactive Oxygen Species	112-115	interleukin 1 beta	Mus musculus	49-57
26786981-8	2016	Peritoneal macrophages isolated from untreated Gal-3(-/-) mice and treated in vitro with bacterial lipopolysaccharide or DSS produce lower amounts of tumour necrosis factor alpha [TNF-alpha] and interleukin beta [IL-1beta] when compared with wild type [WT] cells.	dss	121-124	interleukin 1 beta	Mus musculus	213-221
26540221-6	2016	RESULTS: DMH-CBD treatment downregulated in a dose-dependent manner the mRNA expression of LPS-upregulated pro-inflammatory genes (Il1b, Il6, and Tnf) in BV-2 microglial cells.	Dimenhydrinate	9-12	interleukin 1 beta	Mus musculus	131-135
27533933-6	2016	We further showed that LPS plus ATP activated inflammasome, evidenced by the upregulation of caspase-1 and IL-1beta, which was suppressed by ZYVAD, a caspase-1 inhibitor.	Adenosine Triphosphate	32-35	interleukin 1 beta	Mus musculus	107-115
27533933-6	2016	We further showed that LPS plus ATP activated inflammasome, evidenced by the upregulation of caspase-1 and IL-1beta, which was suppressed by ZYVAD, a caspase-1 inhibitor.	zyvad	141-146	interleukin 1 beta	Mus musculus	107-115
26385227-19	2016	Induction of depression-like behavior by co-administration of IL-1beta and IL-6 was prevented by pretreatment with prazosin alone.	Prazosin	115-123	interleukin 1 beta	Mus musculus	62-70
27074537-7	2016	SAE200 also significantly attenuated DSS-induced increase in IL-6 and IL-1beta, and reductions in IL-10 in colon tissue.	sae200	0-6	interleukin 1 beta	Mus musculus	70-78
27074537-7	2016	SAE200 also significantly attenuated DSS-induced increase in IL-6 and IL-1beta, and reductions in IL-10 in colon tissue.	Dextran Sulfate	37-40	interleukin 1 beta	Mus musculus	70-78
25753147-5	2016	Notably, a short-term DMBA/TPA challenge, modeling the initial stages of chemical skin carcinogenesis treatment, elicited an enhanced inflammation in p38delta-null skin compared with skin of wild-type mice, as assessed by measuring the expression of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-17, and TNFalpha.	9,10-Dimethyl-1,2-benzanthracene	22-26	interleukin 1 beta	Mus musculus	288-296
25753147-5	2016	Notably, a short-term DMBA/TPA challenge, modeling the initial stages of chemical skin carcinogenesis treatment, elicited an enhanced inflammation in p38delta-null skin compared with skin of wild-type mice, as assessed by measuring the expression of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-17, and TNFalpha.	Tetradecanoylphorbol Acetate	27-30	interleukin 1 beta	Mus musculus	288-296
26096705-6	2016	The protective effects due to pretreatment with SFN were associated with the following: suppression of the formation of a lesion area, neuronal death, succinate dehydrogenase activity, apoptosis, microglial activation, and mRNA or protein expression of inflammatory mediators, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, inducible nitric oxide synthase, and cyclooxygenase-2 in the striatum after 3-NP treatment.	sulforaphane	48-51	interleukin 1 beta	Mus musculus	316-338
27222180-8	2016	CONCLUSION: PA treatment can stimulate lipid accumulation in hepatocytes and induce oxidative stress through NOX4 and mitochondria pathway to activate inflammasomes and stimulate the secretion of IL-1beta.	Palmitic Acid	12-14	interleukin 1 beta	Mus musculus	196-204
26987941-11	2016	Irinotecan also induced increased ROS production in enterocytes, oxidative stress, IL-1beta production, neutrophil and eosinophil influx in the ileum.	Irinotecan	0-10	interleukin 1 beta	Mus musculus	83-91
26987941-12	2016	Fullerol treatment decreased production of ROS in the enterocytes, oxidative stress, IL-1beta production, neutrophil and eosinophil influx in the ileum.	fullerol	0-8	interleukin 1 beta	Mus musculus	85-93
26349656-4	2016	Small intestinal damage developed 3 h after indomethacin administration, accompanied by increases in IL-1beta and NLRP3 mRNA expression and mature caspase-1 and IL-1beta levels.	Indomethacin	44-56	interleukin 1 beta	Mus musculus	101-109
26349656-4	2016	Small intestinal damage developed 3 h after indomethacin administration, accompanied by increases in IL-1beta and NLRP3 mRNA expression and mature caspase-1 and IL-1beta levels.	Indomethacin	44-56	interleukin 1 beta	Mus musculus	161-169
26349656-5	2016	In vivo blocking of IL-1beta using neutralizing antibodies attenuated indomethacin-induced damage, whereas exogenous IL-1beta aggravated it.	Indomethacin	70-82	interleukin 1 beta	Mus musculus	20-28
26349656-9	2016	Apyrase, an adenosine triphosphate (ATP) scavenger, or Brilliant Blue G, a purinergic P2X7 receptor antagonist, inhibited the damage as well as caspase-1 activation and IL-1beta processing, despite there being sufficient amounts of pro-IL-1beta and NLRP3.	coomassie Brilliant Blue	55-71	interleukin 1 beta	Mus musculus	169-177
26349656-9	2016	Apyrase, an adenosine triphosphate (ATP) scavenger, or Brilliant Blue G, a purinergic P2X7 receptor antagonist, inhibited the damage as well as caspase-1 activation and IL-1beta processing, despite there being sufficient amounts of pro-IL-1beta and NLRP3.	coomassie Brilliant Blue	55-71	interleukin 1 beta	Mus musculus	236-244
26724567-4	2016	Citreohybridonol also suppressed the expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and other pro-inflammatory cytokines including interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the LPS-stimulated cells.	citreohybridonol	0-16	interleukin 1 beta	Mus musculus	154-171
26724567-4	2016	Citreohybridonol also suppressed the expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and other pro-inflammatory cytokines including interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the LPS-stimulated cells.	citreohybridonol	0-16	interleukin 1 beta	Mus musculus	173-181
26391290-7	2016	Cells treated with haloperidol and risperidone also presented higher concentrations of inflammatory cytokines (IL-1beta, IL-6, TNFalpha) and low levels of IL-6 anti-inflammatory cytokine in a dose-dependent manner.	Haloperidol	19-30	interleukin 1 beta	Mus musculus	111-119
26391290-7	2016	Cells treated with haloperidol and risperidone also presented higher concentrations of inflammatory cytokines (IL-1beta, IL-6, TNFalpha) and low levels of IL-6 anti-inflammatory cytokine in a dose-dependent manner.	Risperidone	35-46	interleukin 1 beta	Mus musculus	111-119
27110761-7	2016	Interleukin (IL)-6, IL-1beta, and tumor necrosis factor-alpha were decreased by GA treatment.	Glycyrrhetinic Acid	80-82	interleukin 1 beta	Mus musculus	20-28
27108091-8	2016	RESULTS: We demonstrate that exposure to silica, alum and polystyrene particulates induces IL-1beta release from macrophages, through lysosomal destabilization.	Silicon Dioxide	41-47	interleukin 1 beta	Mus musculus	91-99
27108091-8	2016	RESULTS: We demonstrate that exposure to silica, alum and polystyrene particulates induces IL-1beta release from macrophages, through lysosomal destabilization.	aluminum sulfate	49-53	interleukin 1 beta	Mus musculus	91-99
27108091-8	2016	RESULTS: We demonstrate that exposure to silica, alum and polystyrene particulates induces IL-1beta release from macrophages, through lysosomal destabilization.	Polystyrenes	58-69	interleukin 1 beta	Mus musculus	91-99
27128484-6	2016	And AZD8055 treatment decreases colonic expression of genes encoding the pro-inflammatory cytokines interferon-gamma, interleukin (IL)-17A, IL-1beta,IL-6 and tumor necrosis factor(TNF)-a and increases colonic expression of anti-inflammatory cytokines IL-10.	(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol	4-11	interleukin 1 beta	Mus musculus	140-148
27053298-4	2016	The increased levels of tumour necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and IL-18 following cold-stress injury were decreased by AC-YVAD-CMK, but not omeprazole, pretreatment.	ac-yvad	141-148	interleukin 1 beta	Mus musculus	54-76
27100888-6	2016	These studies suggest IL-1, via its action on neutrophils, promotes the anti-cancer efficacy of ingenol mebutate, with ingenol mebutate treatment causing both IL-1beta induction and IL-1alpha released from keratinocytes.	3-ingenyl angelate	119-135	interleukin 1 beta	Mus musculus	159-167
26923165-7	2016	Aldosterone increased superoxide production capacity in cerebral arteries, and also mRNA expression of the pro-inflammatory cytokines chemokine (C-C motif) ligand 7 (CCL7), CCL8 and interleukin (IL)-1beta in the brain.	Aldosterone	0-11	interleukin 1 beta	Mus musculus	182-204
26923165-8	2016	These increases were prevented by both spironolactone treatment and endothelial cell MR-deficiency; whereas IL-1beta expression was blocked by spironolactone only.	Spironolactone	143-157	interleukin 1 beta	Mus musculus	108-116
26970305-7	2016	In addition, the remarkable oxidative damage and inflammation induced by NAFLD were both attenuated by DMB treatment, which is reflected by decreased lipid oxidative product, malonaldehyde (MDA) and inflammatory factors, tumor necrosis factor alpha (TNFalpha) and interleukin 1beta (IL-1beta).	demethyleneberberine	103-106	interleukin 1 beta	Mus musculus	264-281
26970305-7	2016	In addition, the remarkable oxidative damage and inflammation induced by NAFLD were both attenuated by DMB treatment, which is reflected by decreased lipid oxidative product, malonaldehyde (MDA) and inflammatory factors, tumor necrosis factor alpha (TNFalpha) and interleukin 1beta (IL-1beta).	demethyleneberberine	103-106	interleukin 1 beta	Mus musculus	283-291
26947454-8	2016	Oroxyloside decreased several LPS-induced inflammatory cytokines, including IL-1beta, IL-6 and TNF-alpha in RAW264.7 and BMDM.	oroxylin A-7-O-glucuronide	0-11	interleukin 1 beta	Mus musculus	76-84
27075683-4	2016	These were correlated with the suppression of NLRP3 inflammasome activation in the liver by SFN as evidenced by decrease in mRNA levels of ASC and caspase-1, caspase-1 enzyme activity, and IL-1beta levels.	sulforaphane	92-95	interleukin 1 beta	Mus musculus	189-197
26944017-2	2016	When administered to the C57BL/6J mice after a 3 days period of cigarettes exposure,TAK-242 significantly decreased the accumulation of macrophages, neutrophils, lymphocytes and DCs, and upregulation of IL-6, IL-8 and TNF-alpha in BAL fluid and lungs in a dose-dependent manner, except MCP-1, IL-1beta and IFN-gamma, which demonstrated that TAK-242 inhibits release of various inflammatory mediators induced by cigarette smoke.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	84-91	interleukin 1 beta	Mus musculus	293-301
27014913-4	2016	The NLRP3 inflammasome is induced by Aldo in a dose- and time-dependent manner, as evidenced by increased NLRP3, ASC, caspase-1, and downstream cytokines, such as interleukin (IL)-1beta and IL-18.	Aldosterone	37-41	interleukin 1 beta	Mus musculus	163-185
26832323-6	2016	In addition, pretreatment with SchB lowered the number of inflammatory cells and pro-inflammatory cytokines including tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 in BALF.	schizandrin B	31-35	interleukin 1 beta	Mus musculus	147-164
26778788-0	2016	Pre-treatment of C57BL6/J mice with the TLR4 agonist monophosphoryl lipid A prevents LPS-induced sickness behaviors and elevations in dorsal hippocampus interleukin-1beta, independent of interleukin-4 expression.	Lipid A	68-75	interleukin 1 beta	Mus musculus	153-170
26857263-7	2016	Investigation of the host microenvironment revealed an alcohol-induced inflammatory response marked by elevated TNFalpha, IL1beta, IL6, and IFNgamma protein levels, as well as increased expression of intercellular molecule-1 (ICAM1) in hepatic tissues after 4 weeks of alcohol consumption.	Alcohols	55-62	interleukin 1 beta	Mus musculus	122-129
26921636-6	2016	Cholesterol crystals, detected in the colon of mice fed with HCD, also promoted NLRP3 inflammasome activation in macrophages, as indicated by elevated expression of cleaved caspase-1, formation of NLRP3-ASC-caspase-1 complex assembly, and higher IL-1beta secretion.	Cholesterol	0-11	interleukin 1 beta	Mus musculus	246-254
25823386-5	2016	RESULTS: Lico F inhibited TNFalpha-induced NF-kappaB activation and mRNA expression of TNFalpha, COX-2, IL-6, IL-1beta, and NOS2.	lico f	9-15	interleukin 1 beta	Mus musculus	110-118
26657007-8	2016	Reverse transcriptase-PCR revealed that mRNA expressions of interleukin (Il)-1beta, Il-6, E-selectin, vascular cell adhesion molecule-1 and collagen type 1 were lower in the CPE group compared with the vehicle group.	cpe	174-177	interleukin 1 beta	Mus musculus	60-82
27012760-7	2016	Here, three (1-3) of diketopiperazines were isolated from two strains of marine-derived bacteria and 1-3 induced potent inhibition of PMA-, TNF-alpha-, IL-1beta (in HUVECs), and CLP-induced EPCR shedding (in mice) via inhibition of phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38, janus kinase (JNK), and extracellular signal-regulated kinase (ERK) 1/2.	Diketopiperazines	21-38	interleukin 1 beta	Mus musculus	152-160
26881857-7	2016	Four days of daily inhalation of ambroxol at 3.75 or 7.5mg/ml for 20 min suppressed the accumulation of neutrophils and macrophages in the bronchoalveolar lavage fluid (BALF) and lung tissues, and inhibited increases in the mRNA and protein levels of tumor necrosis factor (TNF)-alpha, CCL-2 and KC, but not interleukin (IL)-1beta in the CS-exposed mice.	Ambroxol	33-41	interleukin 1 beta	Mus musculus	308-330
26552405-8	2016	Lico A also suppressed LPS-induced TNF-alpha, IL-6, and IL-1beta production both in serum and kidney tissues.	licochalcone A	0-6	interleukin 1 beta	Mus musculus	56-64
26881857-11	2016	Using cultured lung epithelial cells, we demonstrated that pretreatment with ambroxol at 2 or 20 muM inhibited the CSE-induced up-regulation of MUC5AC, TNF-alpha, IL-1beta mRNA levels, which was through inhibiting Erk signaling pathway.	Ambroxol	77-85	interleukin 1 beta	Mus musculus	163-171
26639408-9	2016	Melatonin also attenuated the expressions of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), cleaved caspase-1, interleukin-1beta (IL-1beta), and interleukin-6 (IL-6); these changes were also associated with an increase in the anti-apoptotic factor (Bcl2) and reduction in the pro-apoptotic factor (Bim).	Melatonin	0-9	interleukin 1 beta	Mus musculus	158-175
26867538-6	2016	In addition, TBHQ treatment reduced microglial activation with concomitant reduction in the release of proinflammatory cytokine interleukin-1beta (IL-1 beta).	2-tert-butylhydroquinone	13-17	interleukin 1 beta	Mus musculus	128-145
26867538-6	2016	In addition, TBHQ treatment reduced microglial activation with concomitant reduction in the release of proinflammatory cytokine interleukin-1beta (IL-1 beta).	2-tert-butylhydroquinone	13-17	interleukin 1 beta	Mus musculus	147-156
26639408-9	2016	Melatonin also attenuated the expressions of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), cleaved caspase-1, interleukin-1beta (IL-1beta), and interleukin-6 (IL-6); these changes were also associated with an increase in the anti-apoptotic factor (Bcl2) and reduction in the pro-apoptotic factor (Bim).	Melatonin	0-9	interleukin 1 beta	Mus musculus	177-185
26936418-4	2016	In mice with carrageenan-induced edema, paw thickness and the expression levels of interleukin (IL)-1beta and IL-6 in paw homogenates were significantly decreased in the EOCO (5 and 10 mg/kg) group, as compared with the control group.	Carrageenan	13-24	interleukin 1 beta	Mus musculus	83-105
26772899-9	2016	Dex treatment significantly decreased expression of IL-1beta, IL-6, MMPs -1, -9, -13, and TIMP-1 after 2 days but increased levels of MMP-8, while Doxy treatment significantly decreased IL-1beta, IL-6, MMP-8, and -9, compared to vehicle.	Dexamethasone	0-3	interleukin 1 beta	Mus musculus	52-60
26936233-6	2016	In addition, treatment with olopatadine and naphazoline hydrochloride was able to reduce the levels of inflammatory factors (TNF-alpha, IL-1beta and IL-6), cytokines (IFN-gamma and IL-4), IgE, GMCSF, and NGF in antigen-induced conjunctival vascular hyperpermeability mice.	Olopatadine Hydrochloride	28-39	interleukin 1 beta	Mus musculus	136-144
26936233-6	2016	In addition, treatment with olopatadine and naphazoline hydrochloride was able to reduce the levels of inflammatory factors (TNF-alpha, IL-1beta and IL-6), cytokines (IFN-gamma and IL-4), IgE, GMCSF, and NGF in antigen-induced conjunctival vascular hyperpermeability mice.	Naphazoline	44-69	interleukin 1 beta	Mus musculus	136-144
26498935-6	2016	Our results showed that forsythiaside A significantly inhibited LPS-induced inflammatory mediators TNF-alpha, IL-1beta, NO and PGE2 production.	forsythiaside	24-37	interleukin 1 beta	Mus musculus	110-118
26772899-9	2016	Dex treatment significantly decreased expression of IL-1beta, IL-6, MMPs -1, -9, -13, and TIMP-1 after 2 days but increased levels of MMP-8, while Doxy treatment significantly decreased IL-1beta, IL-6, MMP-8, and -9, compared to vehicle.	Dexamethasone	0-3	interleukin 1 beta	Mus musculus	186-194
26772899-9	2016	Dex treatment significantly decreased expression of IL-1beta, IL-6, MMPs -1, -9, -13, and TIMP-1 after 2 days but increased levels of MMP-8, while Doxy treatment significantly decreased IL-1beta, IL-6, MMP-8, and -9, compared to vehicle.	Doxycycline	147-151	interleukin 1 beta	Mus musculus	186-194
26863933-10	2016	However, the group receiving citrate+sucrose showed augmented fasting glycaemia, glucose intolerance and the expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6 and IL-10) in their AT.	Citric Acid	29-36	interleukin 1 beta	Mus musculus	162-170
30090404-9	2016	Furthermore, DATS co-administration reactivated the KCs inhibited by INH&amp;RFP, which was illustrated by the increase of carbon phagocytosis, and the restoration of the number of activated KCs and IL-1-beta levels in the liver.	diallyl trisulfide	13-17	interleukin 1 beta	Mus musculus	199-208
30090404-9	2016	Furthermore, DATS co-administration reactivated the KCs inhibited by INH&amp;RFP, which was illustrated by the increase of carbon phagocytosis, and the restoration of the number of activated KCs and IL-1-beta levels in the liver.	Adenosine Monophosphate	73-76	interleukin 1 beta	Mus musculus	199-208
27026206-7	2016	CUMS induced elevation in IL-1beta protein levels in the hippocampus, and the cortex was significantly attenuated after 4 weeks of feeding the mice hydrogen-rich water.	cums	0-4	interleukin 1 beta	Mus musculus	26-34
27026206-7	2016	CUMS induced elevation in IL-1beta protein levels in the hippocampus, and the cortex was significantly attenuated after 4 weeks of feeding the mice hydrogen-rich water.	Water	162-167	interleukin 1 beta	Mus musculus	26-34
27026206-9	2016	Our data suggest that the beneficial effects of hydrogen-rich water on depressive-like behavior may be mediated by suppression of the inflammasome activation resulting in attenuated protein IL-1beta and ROS production.	Hydrogen	48-56	interleukin 1 beta	Mus musculus	190-198
27026206-9	2016	Our data suggest that the beneficial effects of hydrogen-rich water on depressive-like behavior may be mediated by suppression of the inflammasome activation resulting in attenuated protein IL-1beta and ROS production.	Water	62-67	interleukin 1 beta	Mus musculus	190-198
26686910-4	2016	Moreover, CX inhibited the LPS-induced up-regulation of tumor necrosis factor alpha (TNF-alpha), interleukin-10 (IL-10), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in Sertoli cells.	Beta-Cryptoxanthin	10-12	interleukin 1 beta	Mus musculus	146-163
26686910-4	2016	Moreover, CX inhibited the LPS-induced up-regulation of tumor necrosis factor alpha (TNF-alpha), interleukin-10 (IL-10), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in Sertoli cells.	Beta-Cryptoxanthin	10-12	interleukin 1 beta	Mus musculus	165-173
26863933-10	2016	However, the group receiving citrate+sucrose showed augmented fasting glycaemia, glucose intolerance and the expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6 and IL-10) in their AT.	Sucrose	37-44	interleukin 1 beta	Mus musculus	162-170
26903297-7	2016	IL-1beta expression in the HFD group was increased in accordance with the enhancement of NLRP3 or iNOS expression in the IPFP, whereas it was inhibited by FEB administration.	Febuxostat	155-158	interleukin 1 beta	Mus musculus	0-8
26974824-8	2016	Moreover, increased expression of interleukin-1beta and downstream phosphorylated-p38-mitogen-activated protein kinase were concordant with apoptosis induction in the placentas of salt water-treated wild-type mice.	Salts	180-184	interleukin 1 beta	Mus musculus	34-51
27011173-4	2016	Koumine induced a decrease in the level of inducible nitric oxide synthase (iNOS) protein, concomitant reduction in the production of nitric oxide (NO) and reduction of the levels of interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha) and IL-1beta.	koumine	0-7	interleukin 1 beta	Mus musculus	247-255
26974824-8	2016	Moreover, increased expression of interleukin-1beta and downstream phosphorylated-p38-mitogen-activated protein kinase were concordant with apoptosis induction in the placentas of salt water-treated wild-type mice.	Water	185-190	interleukin 1 beta	Mus musculus	34-51
26773728-7	2016	Additional experiment showed that rosiglitazone pretreatment inhibited LPS-induced expressions of tumor necrosis factor (Tnf)-alpha, interleukin (Il)-1beta, Il-6, macrophage inflammatory protein (Mip)-2 and keratinocyte-derived chemokine (Kc) in mouse placenta.	Rosiglitazone	34-47	interleukin 1 beta	Mus musculus	133-155
27022259-7	2016	SiNPs induced a significant elevation in pulmonary and renal interleukin 6 and interleukin-1 beta in the lung, liver, and brain.	sinps	0-5	interleukin 1 beta	Mus musculus	79-97
26774050-5	2016	Similarly, AQP4 deficiency augmented the activation of the NF-kappaB pathway and the production of IL-1beta and TNF-alpha in midbrain astrocyte cultures treated with MPP(+) (1-methyl-4-phenylpyridinium).	mangion-purified polysaccharide (Candida albicans)	166-172	interleukin 1 beta	Mus musculus	99-107
26774050-5	2016	Similarly, AQP4 deficiency augmented the activation of the NF-kappaB pathway and the production of IL-1beta and TNF-alpha in midbrain astrocyte cultures treated with MPP(+) (1-methyl-4-phenylpyridinium).	1-Methyl-4-phenylpyridinium	174-201	interleukin 1 beta	Mus musculus	99-107
26849878-6	2016	Furthermore, 4-TBPS significantly inhibited the production of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin- (IL)-1beta, and IL-6.	4-tert-butylphenyl salicylate	13-19	interleukin 1 beta	Mus musculus	140-163
26934748-11	2016	Boron further stimulated the secretion of TNF-alpha, IL-6, IL-1beta, NO and the expression of iNOS by the LPS-primed macrophages.	Boron	0-5	interleukin 1 beta	Mus musculus	59-67
26203683-8	2016	C57BL/6 mice exposed to ozone for 1 day had acute neutrophilic rhinitis, with airway epithelial necrosis and overexpression of mucosal Ccl2 (MCP-1), Ccl11 (eotaxin), Cxcl1 (KC), Cxcl2 (MIP-2), Hmox1, Il1b, Il5, Il6, Il13, and Tnf mRNA.	Ozone	24-29	interleukin 1 beta	Mus musculus	200-204
26852953-5	2016	HTMC concentration-dependently inhibited LPS-induced expression of inflammatory enzymes including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), nitric oxide (NO) production, and the secretion of inflammatory cytokines, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6.	htmc	0-4	interleukin 1 beta	Mus musculus	287-309
26849878-9	2016	Collectively, our data indicate that 4-TBPS significantly (p &lt; 0.01) targets the inflammatory response of macrophages via inhibition of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 through downregulation of the NF-kappaB pathway.	4-tert-butylphenyl salicylate	37-43	interleukin 1 beta	Mus musculus	163-171
26893251-7	2016	Furthermore, cinnamaldehyde also decreased serum IL-1beta and inflammatory gene expression in visceral white adipose tissue.	cinnamaldehyde	13-27	interleukin 1 beta	Mus musculus	49-57
26887341-6	2016	Furthermore, the levels of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) were obviously decreased in the LM-Fe supplemented groups compared with the model group, while the level of interleukin-2 (IL-2) was significantly increased.	lm-fe	155-160	interleukin 1 beta	Mus musculus	69-86
26224376-8	2016	Acute Cd exposure also significantly increased malondialdehyde (MDA) contents, decreased glutathione (GSH) and superoxide dismutase (SOD) activities, and upregulated levels of the pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta), in the testis.	Cadmium	6-8	interleukin 1 beta	Mus musculus	253-270
26224376-8	2016	Acute Cd exposure also significantly increased malondialdehyde (MDA) contents, decreased glutathione (GSH) and superoxide dismutase (SOD) activities, and upregulated levels of the pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta), in the testis.	Cadmium	6-8	interleukin 1 beta	Mus musculus	272-280
26224376-9	2016	In contrast, melatonin pretreatment significantly alleviated these toxic effects, and its mechanism may involve inhibiting MDA level, restoring GSH and SOD activities, and reducing the upregulation of TNF-alpha and IL-1beta.	Melatonin	13-22	interleukin 1 beta	Mus musculus	215-223
26711019-13	2016	Furthermore, PX-12 not only decreased the expression of HIF-1alpha but also decreased the expression of IL-1beta over the injured palm.	1-methylpropyl-2-imidazolyl disulfide	13-18	interleukin 1 beta	Mus musculus	104-112
26998046-5	2016	In addition, the mRNA expression of inducible nitric oxide synthase, TNF-alpha, IL-6 and IL-1beta was suppressed by treatment with TFHDW in LPS-stimulated RAW 264.7 cells.	tfhdw	131-136	interleukin 1 beta	Mus musculus	89-97
26972403-11	2016	Compared to the control group, serum levels of ALT and AST, and mRNA levels of TNF-alpha, IL-6 and IL-1beta were increased in APAP-induced group.	Acetaminophen	126-130	interleukin 1 beta	Mus musculus	99-107
26972403-13	2016	However, compared to APAP-induced group, GS combined with APAP-induced group displayed a decrease of protein expression levels of ASK1, P-ASK1 and P-JNK, a reduction of serum levels of ALT and AST, a decrease in TNF-alpha, IL-6 and IL-1beta mRNA levels, and a low ration of GSSG/GSH.	Acetaminophen	58-62	interleukin 1 beta	Mus musculus	232-240
26656745-5	2016	This study aimed to investigate the effect of chronic administration of melatonin on the expression of inflammation markers (TNF-alpha, IL-1beta, NFkappaB2, HO-1) and apoptosis parameters (BAD, BAX, AIF) in the lung tissue of male senescence-accelerated prone mice (SAMP8).	Melatonin	72-81	interleukin 1 beta	Mus musculus	136-144
26887341-6	2016	Furthermore, the levels of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) were obviously decreased in the LM-Fe supplemented groups compared with the model group, while the level of interleukin-2 (IL-2) was significantly increased.	lm-fe	155-160	interleukin 1 beta	Mus musculus	88-96
26987023-10	2016	Collectively, our data showed that CI inhibits IL-1beta secretion through attenuation of NLRP3 inflammasome activation, leading to an antidiabetic effect by improving glucose metabolism and inhibiting metainflammation.	Glucose	167-174	interleukin 1 beta	Mus musculus	47-55
26912818-5	2016	Glycine and proline only marginally stimulated the IL-8 production by IL-1beta-stimulated gingival fibroblast, whereas glycine dose-dependently inhibited the nitric oxide production by lipopolysaccharide-stimulated mouse macrophage-like RAW264.7 cells.	Glycine	0-7	interleukin 1 beta	Mus musculus	70-78
26912818-5	2016	Glycine and proline only marginally stimulated the IL-8 production by IL-1beta-stimulated gingival fibroblast, whereas glycine dose-dependently inhibited the nitric oxide production by lipopolysaccharide-stimulated mouse macrophage-like RAW264.7 cells.	Proline	12-19	interleukin 1 beta	Mus musculus	70-78
26800690-13	2016	The C2S-coated surface stimulated macrophages to express pro-inflammatory mediators, such as TNF-alpha, IL-6 and IL-1beta, and C2S coating caused less IL-6 but greater IL-1beta production than the 45S5 coating.	A(2)C	4-7	interleukin 1 beta	Mus musculus	113-121
26800690-13	2016	The C2S-coated surface stimulated macrophages to express pro-inflammatory mediators, such as TNF-alpha, IL-6 and IL-1beta, and C2S coating caused less IL-6 but greater IL-1beta production than the 45S5 coating.	A(2)C	4-7	interleukin 1 beta	Mus musculus	168-176
26800690-13	2016	The C2S-coated surface stimulated macrophages to express pro-inflammatory mediators, such as TNF-alpha, IL-6 and IL-1beta, and C2S coating caused less IL-6 but greater IL-1beta production than the 45S5 coating.	A(2)C	127-130	interleukin 1 beta	Mus musculus	168-176
26931361-10	2016	Procyanidins also inhibited morphine-induced increase of interleukin-1beta and activation of NOD-like receptor protein3 (NLRP3) inflammasome.	Proanthocyanidins	0-12	interleukin 1 beta	Mus musculus	57-74
26931361-10	2016	Procyanidins also inhibited morphine-induced increase of interleukin-1beta and activation of NOD-like receptor protein3 (NLRP3) inflammasome.	Morphine	28-36	interleukin 1 beta	Mus musculus	57-74
26851533-8	2016	The proinflammatory cytokines TNF-alpha, IL-1beta, IL-6 and IL-17A were significantly decreased in the infected mice treated with nicotine compared with methyllycaconitine.	Nicotine	130-138	interleukin 1 beta	Mus musculus	41-49
26800098-6	2016	The results showed that pretreatment with pogostone markedly improved survival rate, attenuated the histological alterations in the lung, reduced the MPO and MDA levels, decreased the wet/dry weight ratio of lungs, down-regulated the level of pro-inflammatory mediators including TNF-a, IL-1beta and IL-6.	Pogostone	42-51	interleukin 1 beta	Mus musculus	287-295
26800098-7	2016	Furthermore, pretreatment with pogostone enhanced the Nrf2 dependent genes including NQO-1, GCLC and HO-1 but suppressed NF-kappaB regulated genes including TNF-alpha, IL-1beta and IL-6.	Pogostone	31-40	interleukin 1 beta	Mus musculus	168-176
26987023-8	2016	Attenuated IL-1beta secretion may improve glucose metabolism in the HFD-fed insulin resistance mouse model.	Glucose	42-49	interleukin 1 beta	Mus musculus	11-19
26796031-1	2016	BACKGROUND: The aim of this study was to evaluate the effects of photodynamic therapy with curcumin (PDT) comparatively to 5% sodium hypochlorite (NaOCl) and saline solution on cell viability and cytokine (IL-1beta and IL-6) production by mouse fibroblasts.	Curcumin	91-99	interleukin 1 beta	Mus musculus	206-214
26552059-4	2016	Mechanistic studies revealed that aloperine selectively repressed IL-1beta and IFN-gamma expression by regulating PI3K/Akt/mTOR signaling and NF-kappaB transcriptional activity.	aloperine	34-43	interleukin 1 beta	Mus musculus	66-74
26847386-7	2016	Tumor necrosis factor-alpha, interleukin-1beta and interferon gamma mRNA expression levels were significantly downregulated in the colon tissue of DSS mice treated with 5-FU compared with the untreated DSS mice (P&lt;0.05).	dss	147-150	interleukin 1 beta	Mus musculus	29-46
26847386-7	2016	Tumor necrosis factor-alpha, interleukin-1beta and interferon gamma mRNA expression levels were significantly downregulated in the colon tissue of DSS mice treated with 5-FU compared with the untreated DSS mice (P&lt;0.05).	Fluorouracil	169-173	interleukin 1 beta	Mus musculus	29-46
27051443-7	2016	Especially, the level of IL-1beta mRNA in 50 and 90EtOH/HCl treated group was higher in Korl:ICR and A:ICR than B:ICR.	90etoh	49-55	interleukin 1 beta	Mus musculus	25-33
27051443-7	2016	Especially, the level of IL-1beta mRNA in 50 and 90EtOH/HCl treated group was higher in Korl:ICR and A:ICR than B:ICR.	Hydrochloric Acid	56-59	interleukin 1 beta	Mus musculus	25-33
26925951-8	2016	We thus confirmed this hypothesis by measuring cytokine expression, where we found that nicotine inhibited the production of the pro-inflammatory cytokines TNFalpha, IL-1beta and IL-12, while stimulating the secretion of IL-10, an anti-inflammatory cytokine.	Nicotine	88-96	interleukin 1 beta	Mus musculus	166-174
26645224-10	2016	Minocycline-treated mice had significantly reduced hippocampal TNF-alpha and IL-1beta mRNA levels compared with LPS-treated animals.	Minocycline	0-11	interleukin 1 beta	Mus musculus	77-85
26789651-7	2016	Neurotrophic factor BDNF and GDNF as well as immunomodulatory cytokine IL-10 in spinal cord were elevated in Fasudil-treated mice, while inflammatory cytokine IL-17, IL-1beta, IL-6, and TNF-alpha were obviously inhibited, accompanied by the decrease of inflammatory M1 iNOS and the increase of anti-inflammatory M2 Arg-1, providing a microenvironment that contributes to synaptic protection.	fasudil	109-116	interleukin 1 beta	Mus musculus	166-174
26916550-11	2016	Kinsenoside also decreased IL-1beta, TNF-alpha, and MMP-9 expression, and increased the expression of IL-10 in inflamed joints.	3-glucopyranosyloxybutanolide	0-11	interleukin 1 beta	Mus musculus	27-35
26911867-11	2016	RESULTS: Sub-acute exposures of mice to hydrocarbon-rich ultrafine particles induced: (1) BALF neutrophil elevation; (2) lung mucosal inflammation, and (3) increased BALF IL-1beta concentration; with all three outcomes returning to baseline levels 10 days post-exposure.	Hydrocarbons	40-51	interleukin 1 beta	Mus musculus	171-179
26907256-4	2016	Cudraflavanone D (1) also decreased IL-6, TNF-alpha, IL-12, and IL-1beta production, blocked nuclear translocation of NF-kappaB heterodimers (p50 and p65) by interrupting the degradation and phosphorylation of inhibitor of IkappaB-alpha, and inhibited NF-kappaB binding.	cudraflavanone	0-14	interleukin 1 beta	Mus musculus	64-72
26840084-6	2016	In these polyps, mRNA levels of the downstream targets of NF-jB, such as IL-1beta and IL-6, were decreased by irsogladine maleate treatment.	irsogladine	110-129	interleukin 1 beta	Mus musculus	73-81
26902320-6	2016	CB1R antagonist, knockdown and endocannabinoid synthesis inhibitor abolished FS or IL-1beta-enhanced seizure susceptibility.	Endocannabinoids	31-46	interleukin 1 beta	Mus musculus	83-91
26708749-6	2016	Lithium also restored the negative effects of SIS on cortical and hippocampal interleukin-1beta and NO as well as HPA axis deregulation.	Lithium	0-7	interleukin 1 beta	Mus musculus	78-95
26732631-7	2016	RESULTS: Among the investigated active fractions, the flavonoids from Carthamus tinctorius (Fct), Davallia mariesii (Fdm), and Cinnamomum cassia Twig volatile oils (Vca) from the eight selected herbs effectively promoted IL-1beta and IL-6 release from ANA-1 cells.	Flavonoids	54-64	interleukin 1 beta	Mus musculus	221-229
26895409-11	2016	Furthermore, PA inhibited carrageenan-induced peritoneal production of inflammatory cytokines TNF-alpha and IL-1beta.	pimaric acid	13-15	interleukin 1 beta	Mus musculus	108-116
26895409-11	2016	Furthermore, PA inhibited carrageenan-induced peritoneal production of inflammatory cytokines TNF-alpha and IL-1beta.	Carrageenan	26-37	interleukin 1 beta	Mus musculus	108-116
26732631-8	2016	Saponins from the YTN CMM Glycyrrhiza uralensis (Sgu) were the most potent promoters of IL-1beta and TNF-alpha release.	Saponins	0-8	interleukin 1 beta	Mus musculus	88-96
26103560-7	2016	KEY RESULTS: 1K/DOCA/salt-induced hypertension in mice was associated with increased renal mRNA expression of inflammasome subunits NLRP3, ASC and pro-caspase-1, and the cytokine, pro-IL-1beta, as well as protein levels of active caspase-1 and mature IL-1beta.	Desoxycorticosterone Acetate	16-20	interleukin 1 beta	Mus musculus	184-192
26877061-2	2016	In the current study, we demonstrate that human and murine neutrophils express functional cell-surface P2X7R, which leads to ATP-induced loss of intracellular K(+), NLRP3 inflammasome activation and IL-1beta secretion.	Adenosine Triphosphate	125-128	interleukin 1 beta	Mus musculus	199-207
26698392-8	2016	The results showed that zingerone suppressed LPS-induced BUN, creatinine, and inflammatory cytokines TNF-alpha, IL-6 and IL-1beta levels in a dose-dependent manner.	zingerone	24-33	interleukin 1 beta	Mus musculus	121-129
25388157-2	2016	This study tried to investigate the silica-induced inflammatory and fibrotic changes in the heart and kidney and evaluate the role of interleukin (IL)-1 beta (beta) in silica-induced cardiac and renal damage.	Silicon Dioxide	168-174	interleukin 1 beta	Mus musculus	134-157
25388157-7	2016	Further studies showed that usage of anti-IL-1beta mAb decreased the inflammatory response of the heart and kidney induced by inhalational silica and also attenuated fibrosis in the mouse kidney.	Silicon Dioxide	139-145	interleukin 1 beta	Mus musculus	42-50
25388157-9	2016	Neutralisation of IL-1beta attenuated the silica-induced inflammatory response of the heart and kidney and decreased fibrosis in the mouse kidney.	Silicon Dioxide	42-48	interleukin 1 beta	Mus musculus	18-26
26714044-6	2016	RESULTS: Treatment of obese mice with CS reduced the extension of foam cell coverage in atheromatous plaques of arterial bifurcations by 62.5%, the serum concentration of IL1beta by 70%, TNF-alpha by 82% and selected chemokines by 25-35%.	Chondroitin Sulfates	38-40	interleukin 1 beta	Mus musculus	171-178
26695376-8	2016	Additionally, low RANKL, tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 immunochemistry staining were noted in dopamine-treatment groups.	Dopamine	129-137	interleukin 1 beta	Mus musculus	54-71
26434621-8	2016	Moreover, DEX treatment for 21 and 28 days significantly increased the proteins expression of NLRP-1, Caspase-1, Caspase-5, apoptosis associated speck-like protein (ASC), nuclear factor-kappaB (NF-kappaB), p-NF-kappaB, interleukin-1beta (IL-1beta), IL-18 and IL-6 in the frontal cortex and hippocampus brain tissue.	Dexamethasone	10-13	interleukin 1 beta	Mus musculus	219-236
26434621-8	2016	Moreover, DEX treatment for 21 and 28 days significantly increased the proteins expression of NLRP-1, Caspase-1, Caspase-5, apoptosis associated speck-like protein (ASC), nuclear factor-kappaB (NF-kappaB), p-NF-kappaB, interleukin-1beta (IL-1beta), IL-18 and IL-6 in the frontal cortex and hippocampus brain tissue.	Dexamethasone	10-13	interleukin 1 beta	Mus musculus	238-246
26929598-6	2016	EGCG decreased the immunoreaction and pathological damage by reducing inflammatory factors, such as TNF-alpha, IL-6, IFN-gamma, and IL-1beta.	epigallocatechin gallate	0-4	interleukin 1 beta	Mus musculus	132-140
26926174-10	2016	In addition, neomangiferin inhibited TNBS-induced expression of tumor necrosis factor-alpha, IL-17, IL-6, and IL-1beta, and increased IL-10 expression.	Trinitrobenzenesulfonic Acid	37-41	interleukin 1 beta	Mus musculus	110-118
26842661-8	2016	RESULTS Haloperidol inhibited NF-kappaB activation, and thereby suppressed expression of CD80, as well as secretion of IL-1beta, IL-6, and IL-12 p40.	Haloperidol	8-19	interleukin 1 beta	Mus musculus	119-127
26548719-3	2016	In LPS-stimulated macrophages, non-cytotoxic concentrations of CoQ0 (2.5-10 muM) inhibited iNOS/COX-2 protein expressions with subsequent reductions of NO, PGE2, TNF-alpha and IL-1beta secretions.	ubiquinone-O	63-67	interleukin 1 beta	Mus musculus	176-184
26548719-10	2016	Besides, oral administration of CoQ0 (5 mg/kg) suppressed LPS-induced (1 mg/kg) induction of iNOS/COX-2 and TNF-alpha/IL-1beta through tight regulation of NFkappaB/Nrf2 signaling in mice liver and spleen.	ubiquinone-O	32-36	interleukin 1 beta	Mus musculus	118-126
26103560-7	2016	KEY RESULTS: 1K/DOCA/salt-induced hypertension in mice was associated with increased renal mRNA expression of inflammasome subunits NLRP3, ASC and pro-caspase-1, and the cytokine, pro-IL-1beta, as well as protein levels of active caspase-1 and mature IL-1beta.	Desoxycorticosterone Acetate	16-20	interleukin 1 beta	Mus musculus	251-259
26103560-7	2016	KEY RESULTS: 1K/DOCA/salt-induced hypertension in mice was associated with increased renal mRNA expression of inflammasome subunits NLRP3, ASC and pro-caspase-1, and the cytokine, pro-IL-1beta, as well as protein levels of active caspase-1 and mature IL-1beta.	Salts	21-25	interleukin 1 beta	Mus musculus	184-192
26103560-7	2016	KEY RESULTS: 1K/DOCA/salt-induced hypertension in mice was associated with increased renal mRNA expression of inflammasome subunits NLRP3, ASC and pro-caspase-1, and the cytokine, pro-IL-1beta, as well as protein levels of active caspase-1 and mature IL-1beta.	Salts	21-25	interleukin 1 beta	Mus musculus	251-259
26103560-10	2016	CONCLUSIONS AND IMPLICATIONS: Renal inflammation, fibrosis and elevated BP induced by 1K/DOCA/salt treatment are dependent on inflammasome activity, highlighting the inflammasome/IL-1beta pathway as a potential therapeutic target in hypertension.	Desoxycorticosterone Acetate	89-93	interleukin 1 beta	Mus musculus	179-187
26103560-10	2016	CONCLUSIONS AND IMPLICATIONS: Renal inflammation, fibrosis and elevated BP induced by 1K/DOCA/salt treatment are dependent on inflammasome activity, highlighting the inflammasome/IL-1beta pathway as a potential therapeutic target in hypertension.	Salts	94-98	interleukin 1 beta	Mus musculus	179-187
26434621-9	2016	DEX treatment for 28 days also significantly increased the mRNA expression levels of NLRP-1, Caspase-1, ASC and IL-1beta.	Dexamethasone	0-3	interleukin 1 beta	Mus musculus	112-120
26906195-2	2016	In addition to provoking hyperglycemia, streptozotocin elevated serum levels of IL-1beta and hyaluronic acid, induced edema in the pancreatic insular tissue and its infiltration by inflammatory cells (neutrophils, lymphocytes, and macrophages) and fibroblasts.	Streptozocin	40-54	interleukin 1 beta	Mus musculus	80-88
26893653-5	2016	In addition, ibuprofen was assessed for its effects on the expression levels of NPs and IL-1beta in the hippocampus, cortex and amygdala of the brain.	Ibuprofen	13-22	interleukin 1 beta	Mus musculus	88-96
26363317-4	2016	Moreover, pretreatment of the RAW264.7 cells with Cd for 24 h inhibited the transcriptional status of TNFalpha, IL6, IL1alpha and IL1beta and the release of these cytokines in response to a 6-h lipopolysaccharide (LPS) treatment in a dose-dependent manner.	Cadmium	50-52	interleukin 1 beta	Mus musculus	130-137
25665892-9	2016	Dietary EVOO significantly decreased serum COMP and MMP-3 levels, as well as, the pro-inflammatory cytokines levels (TNF-alpha, IL-1beta and IL-17).	evoo	8-12	interleukin 1 beta	Mus musculus	128-136
26310139-8	2016	TPPU decreased the transforming growth factor-beta1 (TGF-beta1), interleukin-1beta (IL-1beta) and IL-6 levels in the serum of bleomycin-stimulated mice.	TPPU	0-4	interleukin 1 beta	Mus musculus	65-82
26310139-8	2016	TPPU decreased the transforming growth factor-beta1 (TGF-beta1), interleukin-1beta (IL-1beta) and IL-6 levels in the serum of bleomycin-stimulated mice.	TPPU	0-4	interleukin 1 beta	Mus musculus	84-92
26893653-7	2016	Furthermore, the expression levels of NP1 (1.32+-0.47) and IL-1beta (0.99+-0.21) were significantly decreased in the hippocampus of mice following ibuprofen treatment, as compared with the AlCl3-treated mice (8.62+-1.54 and 7.47+-0.53, respectively).	Ibuprofen	147-156	interleukin 1 beta	Mus musculus	59-67
26526764-6	2016	mRNA levels of IL-1beta, CCL2 and Ptgs2 were decreased by 1400W treatment.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	58-63	interleukin 1 beta	Mus musculus	15-23
26893653-7	2016	Furthermore, the expression levels of NP1 (1.32+-0.47) and IL-1beta (0.99+-0.21) were significantly decreased in the hippocampus of mice following ibuprofen treatment, as compared with the AlCl3-treated mice (8.62+-1.54 and 7.47+-0.53, respectively).	Aluminum Chloride	189-194	interleukin 1 beta	Mus musculus	59-67
26481854-15	2016	There was an inverse correlation between levels of SHIP activity in PBMCs and induction of IL1beta production by lipopolysaccharide and adenosine triphosphate (R(2) = .88).	Adenosine Triphosphate	136-158	interleukin 1 beta	Mus musculus	91-98
26791997-12	2016	Nerolidol reduced production of interleukin 1 beta (IL-1beta) in LPS-stimulated, peritoneal macrophages.	nerolidol	0-9	interleukin 1 beta	Mus musculus	32-50
26791997-12	2016	Nerolidol reduced production of interleukin 1 beta (IL-1beta) in LPS-stimulated, peritoneal macrophages.	nerolidol	0-9	interleukin 1 beta	Mus musculus	52-60
26791997-13	2016	Thus, these results showed that nerolidol has antinociceptive activity with possible involvement of the GABAergic system, and anti-inflammatory activity, attributed to the suppression of TNF-alpha and IL-1beta proinflammatory cytokines.	nerolidol	32-41	interleukin 1 beta	Mus musculus	201-209
26675345-5	2016	HCAG also reduced NLRP3 inflammasome-derived IL-1beta secretion by inhibiting the ATP-mediated phosphorylation of AKT and PKC-alpha/delta.	Adenosine Triphosphate	82-85	interleukin 1 beta	Mus musculus	45-53
26481854-18	2016	There is an inverse correlation between SHIP activity and induction of IL1beta production by lipopolysaccharide and adenosine triphosphate in PBMCs.	Adenosine Triphosphate	116-138	interleukin 1 beta	Mus musculus	71-78
26573963-7	2016	RESULTS: The MPO(-/-) neutrophils stimulated by zymosan expressed and secreted significantly higher levels of MIP-1alpha, MIP-1beta, IL-1alpha, IL-1beta, and TNF-alpha than the stimulated wild-type cells.	Zymosan	48-55	interleukin 1 beta	Mus musculus	144-152
26468152-7	2016	Sesamin suppressed LPS-induced inflammatory cytokines TNF-alpha, IL-6, and IL-1beta production.	sesamin	0-7	interleukin 1 beta	Mus musculus	75-83
26688105-6	2016	Intragastric administration of H2O2 significantly up-regulated the expression of TNF-alpha,IL-1beta, and IL-5 (P&lt;0.05).	Hydrogen Peroxide	31-35	interleukin 1 beta	Mus musculus	91-99
26745712-3	2016	DMB significantly decreased the LPS-induced production of pro-inflammatory molecules, such as nitric oxide (NO), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) in RAW264.7 cells.	4,7-dimethoxy-5-methyl-1,3-benzodioxole	0-3	interleukin 1 beta	Mus musculus	113-130
26710167-4	2016	We found that asperuloside can significantly downregulate tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 levels in vitro and in vivo, and treatment with asperuloside significantly reduced the lung wet-to-dry weight, histological alterations and myeloperoxidase activity in a murine model of LPS-induced acute lung injury (ALI).	asperuloside	14-26	interleukin 1 beta	Mus musculus	99-121
26745712-3	2016	DMB significantly decreased the LPS-induced production of pro-inflammatory molecules, such as nitric oxide (NO), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) in RAW264.7 cells.	4,7-dimethoxy-5-methyl-1,3-benzodioxole	0-3	interleukin 1 beta	Mus musculus	132-140
26481278-14	2016	Rapamycin treatment inhibited interleukin-1beta, 6, 13, and 17 on days 7 and 14.	Sirolimus	0-9	interleukin 1 beta	Mus musculus	30-47
26322419-7	2016	In vitro studies demonstrated the upregulation of inflammatory cytokines TNF-alpha and IL-1beta secretion induced by CS extract (CSE) could be attenuated by beta-catenin activator SB216763 and be exacerbated by beta-catenin small-interfering RNA (siRNA), respectively.	Cesium	117-119	interleukin 1 beta	Mus musculus	87-95
26322419-12	2016	Finally, SB216763 treatment significantly ameliorated peribronchial inflammatory cell infiltration, leukocyte influx, and the release of TNF-alpha and IL-1beta in the bronchoalveolar lavage fluid of CS-exposed mice.	SB 216763	9-17	interleukin 1 beta	Mus musculus	151-159
26322419-12	2016	Finally, SB216763 treatment significantly ameliorated peribronchial inflammatory cell infiltration, leukocyte influx, and the release of TNF-alpha and IL-1beta in the bronchoalveolar lavage fluid of CS-exposed mice.	Cesium	199-201	interleukin 1 beta	Mus musculus	151-159
26555554-2	2016	Ethanol also activates other immune receptors, such as NOD-like-receptors, and specifically NLRP3-inflammasome in astroglial cells, to stimulate caspase-1 cleavage and IL-1beta and IL-18 cytokines production.	Ethanol	0-7	interleukin 1 beta	Mus musculus	168-176
26747401-10	2016	Treatment with BI113823 and dexamethasone also significantly reduced total protein content, IgE, TNF-alpha and IL-1beta in lavage fluid, reduced myeloperoxidase activity, mucus secretion in lung tissues, and reduced the expression of B1 receptors, matrix metalloproteinase (MMP)-2 and cyclooxygenase (COX)-2 compared to vehicle-treated mice.	bi113823	15-23	interleukin 1 beta	Mus musculus	111-119
26747401-10	2016	Treatment with BI113823 and dexamethasone also significantly reduced total protein content, IgE, TNF-alpha and IL-1beta in lavage fluid, reduced myeloperoxidase activity, mucus secretion in lung tissues, and reduced the expression of B1 receptors, matrix metalloproteinase (MMP)-2 and cyclooxygenase (COX)-2 compared to vehicle-treated mice.	Dexamethasone	28-41	interleukin 1 beta	Mus musculus	111-119
26842755-12	2016	Furthermore, sGFP-TatNrf2mer expression decreased IL-1beta and IL-6 in the NaIO3-treated mice, and resulted in a 54% decrease in the number of inflammatory cells in the vitreous body of the endotoxin-induced uveitis mouse model.	sodium iodate	75-80	interleukin 1 beta	Mus musculus	50-58
26878795-5	2016	Moreover, fisetin reduced the levels of myeloperoxidase activity, the production of proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6) and the expressions of COX-2 and iNOS in the colon tissues.	fisetin	10-17	interleukin 1 beta	Mus musculus	152-170
26878795-5	2016	Moreover, fisetin reduced the levels of myeloperoxidase activity, the production of proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6) and the expressions of COX-2 and iNOS in the colon tissues.	fisetin	10-17	interleukin 1 beta	Mus musculus	172-180
26806558-6	2016	AMPK also counteracted the IL-1beta- and TNFalpha-induced increase in Cx43 in BSMCs.	bsmcs	78-83	interleukin 1 beta	Mus musculus	27-35
26528946-5	2016	Moreover, compared to BM-MSCs, MenSCs activated with IFN-gamma and IL-1beta produced lower amounts of immunosuppressive factors such as IDO, PDL-1, PGE2, and Activin A and exhibited a substantial lower expression level of IFN-gamma receptor subunits.	Dinoprostone	148-152	interleukin 1 beta	Mus musculus	67-75
26545627-11	2016	U0126 inhibited the increases in the serum levels and vessel wall expression of IL-1beta and TNF-alpha and enhanced the NA shrinkage dose-response curve caused by mmLDL, as observed by a significantly decreased Emax value (P&lt;0.01).	U 0126	0-5	interleukin 1 beta	Mus musculus	80-88
26765310-3	2016	Unlike ATP, gossypol induced much low levels of mature interleukin-1beta (IL-1beta) secretion from mouse peritoneal macrophages primed with LPS, although it caused pro-IL-1beta release similar to that of ATP.	Gossypol	12-20	interleukin 1 beta	Mus musculus	55-72
26765310-3	2016	Unlike ATP, gossypol induced much low levels of mature interleukin-1beta (IL-1beta) secretion from mouse peritoneal macrophages primed with LPS, although it caused pro-IL-1beta release similar to that of ATP.	Gossypol	12-20	interleukin 1 beta	Mus musculus	74-82
26765310-3	2016	Unlike ATP, gossypol induced much low levels of mature interleukin-1beta (IL-1beta) secretion from mouse peritoneal macrophages primed with LPS, although it caused pro-IL-1beta release similar to that of ATP.	Gossypol	12-20	interleukin 1 beta	Mus musculus	168-176
26721437-6	2016	Furthermore, methane treatment obviously suppressed the secretion of proinflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) and increased anti-inflammatory cytokine interleukin-10 (IL-10).	Methane	13-20	interleukin 1 beta	Mus musculus	201-218
26721437-6	2016	Furthermore, methane treatment obviously suppressed the secretion of proinflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) and increased anti-inflammatory cytokine interleukin-10 (IL-10).	Methane	13-20	interleukin 1 beta	Mus musculus	220-228
26789595-6	2016	Our findings evidenced the ability of such inhibitors to reduce host inflammation in silicone implants promoting a thickness reduction of peri-implant fibrous capsule, upregulating IL-10 expression, and reducing the production of both IL-1beta and IL-6.	Silicones	85-93	interleukin 1 beta	Mus musculus	235-243
26789595-0	2016	Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1beta and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model.	Silicones	154-162	interleukin 1 beta	Mus musculus	115-123
26789403-7	2016	On day 28, dasatinib improved lung mechanics, increased M2 macrophage counts in lung parenchyma and granuloma, and was associated with reduction of fraction area of granuloma, fraction area of collapsed alveoli, protein levels of tumor necrosis factor-alpha, interleukin-1beta, transforming growth factor-beta, and reduced neutrophils, M1 macrophages, and collagen fiber content in lung tissue and granuloma in silicotic animals.	Dasatinib	11-20	interleukin 1 beta	Mus musculus	259-276
26751381-7	2016	Resveratrol specifically reduced the inflammatory status in epididymal fat (reduced expression of TNFa and Il1b, whereas the increased macrophage infiltration was unaltered) without affecting the other tissues investigated.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	107-111
26518119-7	2016	These results indicate that TNF-alpha, IL-1beta, and IL-6 have different effects on the lactose synthesis pathway in MECs.	Lactose	88-95	interleukin 1 beta	Mus musculus	39-47
26793111-7	2015	In addition, treatment with celastrol inhibited inflammatory responses, as indicated by the decrease of serum tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6, down-regulation of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), and inactivation of nuclear factor kappaB (NF-kappaB).	celastrol	28-37	interleukin 1 beta	Mus musculus	151-173
26358659-5	2016	In this study, we reported that orally administered alpha-TQ ameliorated memory impairment in APPswe/PS1dE9 transgenic mice, decreased oxidative stress and the levels of Abeta oligomer in the brains of mice, prevented the production of inducible nitric oxide synthase and inflammatory mediators, such as interleukin-6 and interleukin-1beta, and inhibited microglial activation by inhibiting NF-kappaB signaling pathway.	alpha-tq	52-60	interleukin 1 beta	Mus musculus	322-339
26739627-7	2016	Ozone-induced neutrophilic airway inflammation, accompanied an increased production of IL-1beta, IL-18, IL-17A, Granulocyte-colony stimulating factor (G-CSF), Interferon-gamma inducible protein 10 (IP-10) and BALF protein in the lung.	Ozone	0-5	interleukin 1 beta	Mus musculus	87-95
26566726-5	2016	IL-1beta also dose dependently reduced endothelial-dependent relaxation by ACh.	Acetylcholine	75-78	interleukin 1 beta	Mus musculus	0-8
26566726-9	2016	Tempol, a SOD mimetic, partially restored ACh responsiveness in the IL-1beta-treated aorta.	Acetylcholine	42-45	interleukin 1 beta	Mus musculus	68-76
26566726-11	2016	IL-1beta increased ROS and decreased the phospho-endothelial nitric oxide synthase (Ser(1177))-to-endothelial nitric oxide synthase ratio in the nontransgenic aorta.	Rosiglitazone	19-22	interleukin 1 beta	Mus musculus	0-8
26566726-11	2016	IL-1beta increased ROS and decreased the phospho-endothelial nitric oxide synthase (Ser(1177))-to-endothelial nitric oxide synthase ratio in the nontransgenic aorta.	Serine	84-87	interleukin 1 beta	Mus musculus	0-8
26645352-9	2016	Furthermore, an increased expression of TLR2, TLR6 and pro-inflammatory markers including chemokine (C-C motif) ligand 2, interleukin (IL)-1beta, tumour necrosis factor alpha and IL-6 was found in DSS-treated mice with L. rhamnosus supplementation.	dss	197-200	interleukin 1 beta	Mus musculus	122-144
26643169-7	2016	Our results indicated that EGCG significantly suppressed the expression of tumor necrosis factor alpha (TNFalpha), interleukin-1beta, interleukin-6, and inducible nitric oxide synthase (iNOS) in Abeta-stimulated EOC 13.31 microglia.	epigallocatechin gallate	27-31	interleukin 1 beta	Mus musculus	115-132
25362043-11	2016	Colchicine, at low concentration (10 nM) achieved in gout flare prophylaxis dosing, promoted phosphorylation of AMPKalpha and macrophage M2 polarisation, and reduced activation of caspase-1 and release of IL-1beta and CXCL1 by MSU crystals in BMDMs in vitro.	Colchicine	0-10	interleukin 1 beta	Mus musculus	205-213
26492523-12	2016	In addition, 5z-7-oxozeaenol, LY294002, U0126 and aspirin prevented the IL-1beta-induced MCP-1 secretion of pulp cells.	5-7-oxo-zeaenol	13-28	interleukin 1 beta	Mus musculus	72-80
26492523-12	2016	In addition, 5z-7-oxozeaenol, LY294002, U0126 and aspirin prevented the IL-1beta-induced MCP-1 secretion of pulp cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	30-38	interleukin 1 beta	Mus musculus	72-80
26492523-12	2016	In addition, 5z-7-oxozeaenol, LY294002, U0126 and aspirin prevented the IL-1beta-induced MCP-1 secretion of pulp cells.	U 0126	40-45	interleukin 1 beta	Mus musculus	72-80
26492523-12	2016	In addition, 5z-7-oxozeaenol, LY294002, U0126 and aspirin prevented the IL-1beta-induced MCP-1 secretion of pulp cells.	Aspirin	50-57	interleukin 1 beta	Mus musculus	72-80
26725530-12	2016	These results indicate that mRNA expression of Il1beta, Il10, Tnf, Ttr, Mt1, and Gpx3 in mouse blood may provide useful surrogate markers of APAP-induced hepatotoxicity.	Acetaminophen	141-145	interleukin 1 beta	Mus musculus	47-54
26054709-5	2016	Enzyme-linked immunosorbent assays showed that bafilomycin A1 can significantly decrease the subtoxic concentration of CoNP-induced levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6), but has no effect on anti-inflammatory cytokines (transforming growth factor-beta and interleukin-10) in RAW264.7 cells.	bafilomycin	47-58	interleukin 1 beta	Mus musculus	199-216
26054709-5	2016	Enzyme-linked immunosorbent assays showed that bafilomycin A1 can significantly decrease the subtoxic concentration of CoNP-induced levels of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6), but has no effect on anti-inflammatory cytokines (transforming growth factor-beta and interleukin-10) in RAW264.7 cells.	conp	119-123	interleukin 1 beta	Mus musculus	199-216
30003120-8	2016	The nodose neurons express receptors for TNF and IL-1beta, and we show that exposing them to TNF and IL-1beta significantly stimulates their calcium uptake.	Calcium	141-148	interleukin 1 beta	Mus musculus	49-57
27150139-0	2016	Chikusetsusaponin IVa Methyl Ester Isolated from the Roots of Achyranthes japonica Suppresses LPS-Induced iNOS, TNF-alpha, IL-6, and IL-1beta Expression by NF-kappaB and AP-1 Inactivation.	methyl ester	22-34	interleukin 1 beta	Mus musculus	133-141
27150139-3	2016	CS-ME concentration-dependently inhibited LPS-induced tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 and IL-1beta production in RAW264.7 macrophages and mouse peritoneal macrophages.	cs-me	0-5	interleukin 1 beta	Mus musculus	115-123
27150139-4	2016	Consistent with these findings, CS-ME suppressed LPS-induced expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 at protein level as well as iNOS, COX-2, TNF-alpha, IL-6, and IL-1beta at mRNA level.	cs-me	32-37	interleukin 1 beta	Mus musculus	193-201
27150139-6	2016	The anti-inflammatory properties of CS-ME might result from suppression of iNOS, COX-2, TNF-alpha, IL-6, and IL-1beta expression through downregulation of NF-kappaB and AP-1 in macrophages.	cs-me	36-41	interleukin 1 beta	Mus musculus	109-117
30003120-8	2016	The nodose neurons express receptors for TNF and IL-1beta, and we show that exposing them to TNF and IL-1beta significantly stimulates their calcium uptake.	Calcium	141-148	interleukin 1 beta	Mus musculus	101-109
26365025-4	2016	Results indicated that a history of binge-like ethanol drinking promoted a significant increase of IL-1beta mRNA expression within the amygdala, and immunohistochemistry analyses revealed that the basolateral amygdala (BLA), but not central amygdala (CeA), exhibited significantly increased IL-1beta immunoreactivity.	Ethanol	47-54	interleukin 1 beta	Mus musculus	99-107
27800490-13	2016	Pretreatment with parthenolide, but not QNZ, blocked Resistin-enhanced IL-1beta expression in HCAECs.	parthenolide	18-30	interleukin 1 beta	Mus musculus	71-79
28119924-9	2016	DAP treatment decreased the overexpression of TNF-alpha, IL-1beta, and IL-6 and attenuated neural cells apoptosis.	daphnetin	0-3	interleukin 1 beta	Mus musculus	57-65
26254234-8	2016	Our results showed that exploratory laparotomy with isoflurane anesthesia impaired the contextual fear memory, increased expression of Nox2, 8-OH-dG, CD11b, and IL-1beta, and down-regulated BDNF expression in the hippocampus at 7 d post-surgery.	Isoflurane	52-62	interleukin 1 beta	Mus musculus	161-169
27189760-9	2016	Knockdown of Tbeta4 enhanced ethanol-induced inflammatory mediators tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) and nitric oxide (NO) in BV-2 cells was performed.	Ethanol	29-36	interleukin 1 beta	Mus musculus	112-129
26554632-7	2016	These drugs suppressed the ability of lipopolysaccharide to stimulate the synthesis and secretion of nitric oxide and inflammatory cytokines and chemokines, such as IL6, IL1beta, CXCL2, and CSF3, in macrophage-like RAW264.7 cells.	Nitric Oxide	101-113	interleukin 1 beta	Mus musculus	170-177
26849230-12	2016	It was also observed that Myrtol standardized inhibited TGF-beta1 and a series of pro-inflammatory cytokines including TNF-alpha, IL-1beta, IL-6, PGE2.	myrtol	26-32	interleukin 1 beta	Mus musculus	130-138
28450796-6	2016	Ellagic acid significantly (p &lt; 0.01) reduced serum levels of pro-inflammatory cytokines: interleukin 1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin 17 (IL-17).	Ellagic Acid	0-12	interleukin 1 beta	Mus musculus	93-110
28450796-6	2016	Ellagic acid significantly (p &lt; 0.01) reduced serum levels of pro-inflammatory cytokines: interleukin 1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin 17 (IL-17).	Ellagic Acid	0-12	interleukin 1 beta	Mus musculus	112-120
26515692-12	2016	CPZ induced an increase in the expression of IL-1beta and a decrease in MCP-1, CCR-2, MBP and GST-pi, as well as promoting damage in the structure and ultra-structure of the myelin sheath.	Cuprizone	0-3	interleukin 1 beta	Mus musculus	45-53
28044086-6	2016	Histological analysis showed that phloretin suppressed the severity of RA and effectively mitigated joint inflammation and cartilage- and bone-destruction via reducing proinflammatory cytokine productions (TNF-alpha, IL-6, IL-1beta, and IL-17).	Phloretin	34-43	interleukin 1 beta	Mus musculus	223-231
26556104-5	2016	IL-1beta suppressed isoproterenol-induced UCP1 mRNA expression in C3H10T1/2 adipocytes, and this effect was partially but significantly abrogated by inhibition of extracellular signal-regulated kinase (ERK).	Isoproterenol	20-33	interleukin 1 beta	Mus musculus	0-8
26556104-6	2016	IL-1beta also suppressed the isoproterenol-induced activation of the UCP1 promoter and transcription factors binding to the cAMP response element.	Isoproterenol	29-42	interleukin 1 beta	Mus musculus	0-8
26556104-6	2016	IL-1beta also suppressed the isoproterenol-induced activation of the UCP1 promoter and transcription factors binding to the cAMP response element.	Cyclic AMP	124-128	interleukin 1 beta	Mus musculus	0-8
27630735-10	2016	VAL inhibited the production and expression of proinflammatory cytokines IL-1beta and IL-6 in LPS-stimulated RAW 264.7 cells.	valencene	0-3	interleukin 1 beta	Mus musculus	73-81
26586620-6	2016	Data demonstrate that polyozellin induced potent inhibition of PMA-, TNF-alpha-, IL-1beta- (in HUVECs), and CLP-induced EPCR shedding (in mice) via inhibition of phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38, janus kinase (JNK), and extracellular signal-regulated kinase (ERK) 1/2.	polyozellin	22-33	interleukin 1 beta	Mus musculus	81-89
28042486-6	2016	In mice, Sild-Met-Leu reduced the diet induced increases of ALT, TGFbeta, PAI-1, IL1beta, and TNFalpha, hepatic collagen expression, and nearly completely reversed hepatocyte ballooning and triglyceride accumulation, while all two-way combinations had only modest effects.	sild-met-leu	9-21	interleukin 1 beta	Mus musculus	81-88
26672918-9	2016	Our results showed that SA attenuated LPS-induced lung pathological changes, edema, the expression of cycloxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in lung tissues, as well as TNF-alpha, IL-6, IL-1beta, and NO production in mice.	soyasaponin Ab	24-26	interleukin 1 beta	Mus musculus	214-222
26672918-11	2016	SA also inhibited LPS-induced TNF-alpha, IL-6 and IL-1beta production as well as NF-kappaB activation in alveolar macrophages.	soyasaponin Ab	0-2	interleukin 1 beta	Mus musculus	50-58
26655680-9	2016	Divalent flagellin immunization also drastically reduced pro-inflammatory cytokine levels (TNF alpha and IL-1beta) in renal homogenates as determined by ELISA.	divalent flagellin	0-18	interleukin 1 beta	Mus musculus	105-113
26758315-9	2016	Additionally, silymarin treatment mitigated HFD-increased plasma IL-1beta, TNF-alpha levels, and HFD-enhanced hepatic NO, TLR4, and iNOS expression in mice.	Silymarin	14-23	interleukin 1 beta	Mus musculus	65-73
26604089-7	2016	Butyrate pretreatment also significantly ameliorated contents of malondialdehyde (MDA) and carbonyl proteins, and decreased levels of IL-1beta, TNF-alpha and IL-6.	Butyrates	0-8	interleukin 1 beta	Mus musculus	134-142
26325539-9	2016	Cultured hepatic macrophages from GalN/LPS-treated knockout mice had similarly increased IL-1beta production.	Galactosamine	34-38	interleukin 1 beta	Mus musculus	89-97
26923011-8	2016	The STZ treatment also increased the number of Iba-1-positive and CD68-positive microglial cells, astrocytes, and IL-1beta, IL-6, IL-10, and IL-18 levels in the hippocampus, but not in the midbrain or cerebellum.	Streptozocin	4-7	interleukin 1 beta	Mus musculus	114-122
26269198-5	2016	We discovered that sulforaphane inhibits caspase-1 autoproteolytic activation and interleukin-1beta maturation and secretion downstream of the nucleotide-binding oligomerization domain-like receptor leucine-rich repeat proteins NLRP1 and NLRP3, NLR family apoptosis inhibitory protein 5/NLR family caspase-1 recruitment domain-containing protein 4 (NAIP5/NLRC4), and absent in melanoma 2 (AIM2) inflammasome receptors.	sulforaphane	19-31	interleukin 1 beta	Mus musculus	82-99
26535997-3	2016	In wild-type mice, acute inflammation induced by single injections of heat-killed Brucella abortus or interleukin-1beta (IL-1beta) decreased serum iron within 6 h, and was accompanied by significant increases in osseous Fgf23 mRNA expression and serum levels of C-terminal FGF23, but no changes in intact FGF23.	Iron	147-151	interleukin 1 beta	Mus musculus	121-129
26442661-7	2016	nNOS, IL-1beta, and TNF-alpha were increased by MDMA in CPu of adults, whereas in adolescents, levels were only elevated after combined MDMA plus caffeine.	N-Methyl-3,4-methylenedioxyamphetamine	48-52	interleukin 1 beta	Mus musculus	6-14
26269198-8	2016	Sulforaphane was also found to inhibit cell recruitment to the peritoneum and interleukin-1beta secretion in an in vivo peritonitis model of acute gout and to reverse NLRP1-mediated murine resistance to Bacillus anthracis spore infection.	sulforaphane	0-12	interleukin 1 beta	Mus musculus	78-95
27021549-5	2016	Pretreatment with absolute ethanol extract of Angelicae Dahuricae Radix suppressed the LPS-stimulated inducible nitric oxide synthase, interleukin-1beta, and cycloxygenase-2 expression.	Ethanol	27-34	interleukin 1 beta	Mus musculus	135-152
26807019-8	2016	Further results showed that CA treatment markedly inhibited APAP-induced pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6 and MCP-1 mRNA expression and the levels of phosphorylated IkappaBalpha and p65 protein in the liver.	Acetaminophen	60-64	interleukin 1 beta	Mus musculus	111-119
26535997-4	2016	Chronic inflammation induced by repeated bacteria or IL-1beta injections decreased serum iron, increased osseous Fgf23 mRNA, and serum C-terminal FGF23, but modestly increased biologically active, intact FGF23 serum levels.	Iron	89-93	interleukin 1 beta	Mus musculus	53-61
26689330-2	2016	As such, biglycan triggers the synthesis and maturation of interleukin-1beta (IL-1beta) in a Toll-like receptor (TLR) 2-, TLR4-, and reactive oxygen species (ROS)-dependent manner.	Reactive Oxygen Species	133-156	interleukin 1 beta	Mus musculus	59-76
26689330-2	2016	As such, biglycan triggers the synthesis and maturation of interleukin-1beta (IL-1beta) in a Toll-like receptor (TLR) 2-, TLR4-, and reactive oxygen species (ROS)-dependent manner.	Reactive Oxygen Species	133-156	interleukin 1 beta	Mus musculus	78-86
26689330-2	2016	As such, biglycan triggers the synthesis and maturation of interleukin-1beta (IL-1beta) in a Toll-like receptor (TLR) 2-, TLR4-, and reactive oxygen species (ROS)-dependent manner.	Reactive Oxygen Species	158-161	interleukin 1 beta	Mus musculus	59-76
27738387-6	2016	TNF-alpha and IL-1beta, as well as iNOS dependent NO production, resulted significantly inhibited by folic acid pretreatment in LPS-activated BV-2 cells.	Folic Acid	101-111	interleukin 1 beta	Mus musculus	14-22
26689330-2	2016	As such, biglycan triggers the synthesis and maturation of interleukin-1beta (IL-1beta) in a Toll-like receptor (TLR) 2-, TLR4-, and reactive oxygen species (ROS)-dependent manner.	Reactive Oxygen Species	158-161	interleukin 1 beta	Mus musculus	78-86
26924896-0	2016	Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1beta Axis in Microglia.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	85-93
28100936-6	2016	Moreover, the mRNA and protein levels of IL-1beta, IL-6, IL-17, IL-18, and TNF-alpha were significantly lower in the group of mice receiving the COS diet; also the jejunal production of toll-like receptor-4 (TLR-4) was suppressed in the COS group.	Chitosan	145-148	interleukin 1 beta	Mus musculus	41-49
28104929-7	2016	The effects of dapagliflozin on the IL-1beta production in culturing primary macrophages of wild type and NLRP3-/- knockout mice were investigated for mechanism analyses.	dapagliflozin	15-28	interleukin 1 beta	Mus musculus	36-44
28104929-10	2016	Also, reduced production of IL-1beta, IL-18, NLRP3 protein, and mitochondrial ROS in the aortic tissues was detected with dapagliflozin treatment.	dapagliflozin	122-135	interleukin 1 beta	Mus musculus	28-36
28104929-13	2016	Dapagliflozin may be of therapeutic potential for diabetic atherosclerosis induced by high-fat diet, and these benefits may depend on the inhibitory effect on the secretion of IL-1beta by macrophages via the ROS-NLRP3-caspase-1 pathway.	dapagliflozin	0-13	interleukin 1 beta	Mus musculus	176-184
28104929-13	2016	Dapagliflozin may be of therapeutic potential for diabetic atherosclerosis induced by high-fat diet, and these benefits may depend on the inhibitory effect on the secretion of IL-1beta by macrophages via the ROS-NLRP3-caspase-1 pathway.	Reactive Oxygen Species	208-211	interleukin 1 beta	Mus musculus	176-184
26924896-9	2016	NLRP3 expression and IL-1beta cleavage were well inhibited by resveratrol dose-dependently.	Resveratrol	62-73	interleukin 1 beta	Mus musculus	21-29
26924896-10	2016	The in vitro results showed that in the BV2 cell lines resveratrol prevents ATP induced NLRP3 activation and IL-1beta cleavage, which were reversed by the sirtuin 1 inhibitor, nicotinamide.	Resveratrol	55-66	interleukin 1 beta	Mus musculus	109-117
26924896-10	2016	The in vitro results showed that in the BV2 cell lines resveratrol prevents ATP induced NLRP3 activation and IL-1beta cleavage, which were reversed by the sirtuin 1 inhibitor, nicotinamide.	Niacinamide	176-188	interleukin 1 beta	Mus musculus	109-117
26924896-11	2016	In conclusion, resveratrol improves the spatial memory in mice with SAE and inhibits the NLRP3/IL-1beta axis in the microglia.	Resveratrol	15-26	interleukin 1 beta	Mus musculus	95-103
27846628-2	2016	Since NLRP3 inflammasome activation controls the maturation and release of proinflammatory cytokines, especially interleukin-1beta (IL-1beta) and IL-18 in ischemia stroke, we suppose that minocycline may be involved in the regulation of NLRP3 inflammasome activation.	Minocycline	188-199	interleukin 1 beta	Mus musculus	113-130
27433030-6	2016	These findings suggest that XO may be a potential target of HSYA via direct binding inhibition and the combination of HSYA-XO suppresses LPS-induced ROS generation, contributing to the depression of NLRP3 inflammasome and inhibition of IL-1beta secretion in macrophages.	ros	149-152	interleukin 1 beta	Mus musculus	236-244
25502294-4	2016	Likewise, P2X7R participated in the AMPH-induced increase of the proinflammatory and excitotoxic environment, as demonstrated by the reversal of IL-1beta, TNF-alpha, and TBARS levels caused by P2X7R blocking.	Dextroamphetamine	36-40	interleukin 1 beta	Mus musculus	145-153
27524862-5	2016	ATP-induced IL-1beta and lactate dehydrogenase (LDH) release were assessed by specific colorimetric assays.	Adenosine Triphosphate	0-3	interleukin 1 beta	Mus musculus	12-20
27524862-8	2016	ATP caused rapid IL-1beta release in a concentration-dependent manner, and this process was completely impaired by the P2X7 antagonist, AZ10606120.	Adenosine Triphosphate	0-3	interleukin 1 beta	Mus musculus	17-25
27524862-8	2016	ATP caused rapid IL-1beta release in a concentration-dependent manner, and this process was completely impaired by the P2X7 antagonist, AZ10606120.	AZ10606120	136-146	interleukin 1 beta	Mus musculus	17-25
27524862-9	2016	In contrast, 5,7-dibromo-N-(p-methoxybenzyl)isatin (NAI) and 3-{4-[5,7-dibromo-1-(4-methoxybenzyl)-2-oxoindolin-3-ylidenamino]phenyl}propanoic acid (NAI-imine) enhanced P2X7-induced IL-1beta release by twofold compared to that of isatin and the parent molecule, 5,7-dibromoisatin.	3-{4-[5,7-dibromo-1-(4-methoxybenzyl)-2-oxoindolin-3-ylidenamino]phenyl}propanoic acid	61-147	interleukin 1 beta	Mus musculus	182-190
27524862-12	2016	In conclusion, this study demonstrates that N-alkyl-substituted isatins enhance P2X7 receptor-induced IL-1beta release from murine macrophages.	n-alkyl-substituted isatins	44-71	interleukin 1 beta	Mus musculus	102-110
26647861-8	2016	In LPS-induced hepatitis, treatment with LY294002 clearly inhibited intrahepatic synthesis of various disease-relevant proinflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-6, IL-1beta and interferon-gamma.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	interleukin 1 beta	Mus musculus	205-213
27846628-2	2016	Since NLRP3 inflammasome activation controls the maturation and release of proinflammatory cytokines, especially interleukin-1beta (IL-1beta) and IL-18 in ischemia stroke, we suppose that minocycline may be involved in the regulation of NLRP3 inflammasome activation.	Minocycline	188-199	interleukin 1 beta	Mus musculus	132-140
26730154-10	2015	Rottlerin treatment also significantly decreased serum levels of HMGB1 at 6, 12, and 24 h, TNF-alpha, IL-6 and IL-1 beta at 12 h compared with the control group (P &lt; 0.01).	rottlerin	0-9	interleukin 1 beta	Mus musculus	111-120
26651527-5	2015	This inhibitory effect was associated with inhibition on TPA-induced up-regulation of pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	Tetradecanoylphorbol Acetate	57-60	interleukin 1 beta	Mus musculus	113-121
26592483-7	2016	DF2755A given orally was well absorbed (88.2%), and it was able to reduce, in a dose (3-30mg/kg)-dependent manner, inflammatory hyperalgesia induced by carrageenan, LPS and CXCL1/KC as well as neutrophil recruitment and IL-1beta production.	DF2755A	0-7	interleukin 1 beta	Mus musculus	220-228
26588227-9	2015	The pro-inflammatory cytokine expression in the mouse colon, including TNF-alpha, IL-6, INF-gamma, IL-17, and IL-1beta, was significantly up-regulated by DSS treatment, but was inhibited upon PL administration.	dss	154-157	interleukin 1 beta	Mus musculus	110-118
26702389-6	2015	Our results provided evidence that Dex treatment attenuated LPS-activated NF-kappaB p65 activation, as well as the production of tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta at the level of both mRNA and protein in spleen.	Dexmedetomidine	35-38	interleukin 1 beta	Mus musculus	177-194
26601804-6	2015	In L4-6 spinal cord, troxerutin reduced the expression of INF-gamma, IL-1beta, TNF-alpha, and activation of NF-kappaB(p65).	troxerutin	21-31	interleukin 1 beta	Mus musculus	69-77
26607465-13	2015	Nicorandil reduced the concentrations of interleukin-1beta, CXCL-1 and prostaglandin E2 in the pleural exudate.	Nicorandil	0-10	interleukin 1 beta	Mus musculus	41-58
26616878-2	2015	In this LPS-induced model of brain inflammation, administration of KHG26693 effectively prevented increases in the levels of IL-1beta, TNF-alpha, prostaglandin E2, malondialdehyde, and nitric oxide, and mitigated reductions in the levels of superoxide dismutase in the hippocampus.	N-adamantyl-4-methylthiazol-2-amine	67-75	interleukin 1 beta	Mus musculus	125-133
26676341-13	2015	Serum HMGB1 levels at 6, 12, and 24 h, as well as serum TNF-alpha, IL-6, and IL-1beta levels at 12 h, were significantly lower in the DMS treatment group than in the control group (P &lt; 0.01 for all).	N,N-dimethylsphingosine	134-137	interleukin 1 beta	Mus musculus	77-85
25850373-3	2015	Bi-daily subcutaneous injections of morphine to mice over 7 days induced thermal hyperalgesia as measured by both the hot-plate and tail-immersion tests, and spinal astroglial activation with increased spinal gene expression of DAAO, glial fibrillary acidic protein (GFAP) and pro-inflammatory cytokines (interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha)).	Morphine	36-44	interleukin 1 beta	Mus musculus	305-322
25850373-3	2015	Bi-daily subcutaneous injections of morphine to mice over 7 days induced thermal hyperalgesia as measured by both the hot-plate and tail-immersion tests, and spinal astroglial activation with increased spinal gene expression of DAAO, glial fibrillary acidic protein (GFAP) and pro-inflammatory cytokines (interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha)).	Morphine	36-44	interleukin 1 beta	Mus musculus	324-332
26588227-9	2015	The pro-inflammatory cytokine expression in the mouse colon, including TNF-alpha, IL-6, INF-gamma, IL-17, and IL-1beta, was significantly up-regulated by DSS treatment, but was inhibited upon PL administration.	pl	192-194	interleukin 1 beta	Mus musculus	110-118
26744884-5	2015	The mRNA transcript levels of inflammatory-related genes (TNF-alpha and IL1-beta) were elevated in the spleen cells of mice treated with ZnO NPs at 12h.	Zinc Oxide	137-140	interleukin 1 beta	Mus musculus	72-80
28955817-8	2016	Clodronate liposome treatment also decreased the mRNA expression levels of inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) in the skeletal muscle after exhaustive exercise.	Clodronic Acid	0-10	interleukin 1 beta	Mus musculus	110-118
26049169-7	2015	Furthermore, tannic acid treatment inhibited DfE induced tumor necrosis factor (TNF)alpha, high mobility group protein (HMG)B1, receptor for advanced glycation end products (RAGE), extracellular signal-regulated kinase (ERK)1/2, NFkappaB, cyclooxygenase (COX)2, IL-1beta and increased the protein expression of peroxisome proliferator-activated receptor (PPAR)gamma.	Tannins	13-24	interleukin 1 beta	Mus musculus	262-270
26049169-7	2015	Furthermore, tannic acid treatment inhibited DfE induced tumor necrosis factor (TNF)alpha, high mobility group protein (HMG)B1, receptor for advanced glycation end products (RAGE), extracellular signal-regulated kinase (ERK)1/2, NFkappaB, cyclooxygenase (COX)2, IL-1beta and increased the protein expression of peroxisome proliferator-activated receptor (PPAR)gamma.	1,1-difluoroethane	45-48	interleukin 1 beta	Mus musculus	262-270
26505975-6	2015	Real-time PCR detected a remarkable increase in the expression of IL-1beta, IL-6, TNF-alpha, and IL-4 in DSS-treated NHE8(-/-) mice compared with DSS-treated wild-type littermates.	dss	105-108	interleukin 1 beta	Mus musculus	66-74
26018497-11	2015	Moreover, the chronic AlCl3 administration raised the proinflammatory cytokines (interleukin-1beta and tumor necrosis factor-alpha) level and increased acetylcholinesterase activity and reduced the BDNF content in the hippocampus of AlCl3-treated animals.	Aluminum Chloride	22-27	interleukin 1 beta	Mus musculus	81-130
25491246-6	2015	RESULTS: Four days after DNBS administration, colon nuclear factor NF-kappaB translocation and MAP kinase phospho-JNK activation were increased as well as cytokine production such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta.	dinitrobenzenesulfonic acid	25-29	interleukin 1 beta	Mus musculus	221-243
26345246-3	2015	It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6), necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in a dose-dependent manner.	Silybin	25-34	interleukin 1 beta	Mus musculus	155-172
26744884-6	2015	RESULTS: The elevated levels of TNF-alpha and IL1-beta in supernatants of spleen cell cultures of mice treated with ZnO NPs were also observed at 24h.	Zinc Oxide	116-119	interleukin 1 beta	Mus musculus	46-54
26345246-3	2015	It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6), necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in a dose-dependent manner.	Silybin	25-34	interleukin 1 beta	Mus musculus	174-182
26178478-6	2015	OSR-treated group (250 mg/kg) markedly reduced the inflammatory-related protein prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interleukin-8 (IL-8).	oxysophoridine	0-3	interleukin 1 beta	Mus musculus	146-163
26345246-3	2015	It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6), necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	143-146	interleukin 1 beta	Mus musculus	155-172
26345246-3	2015	It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced interleukin-1beta (IL-1beta), interleukin-6 (IL-6), necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in a dose-dependent manner.	Tetradecanoylphorbol Acetate	143-146	interleukin 1 beta	Mus musculus	174-182
26663010-13	2015	In addition, ankaflavin significantly decreased the proliferation of Kupffer cells and the expression of TNF-alpha, IL-6 and IL-1 beta protein in isolated Kupffer cells stimulated by TNF-alpha.	ankaflavin	13-23	interleukin 1 beta	Mus musculus	125-134
26395271-0	2015	Sulfasalazine augments a pro-inflammatory response in interleukin-1beta-stimulated amniocytes and myocytes.	Sulfasalazine	0-13	interleukin 1 beta	Mus musculus	54-71
26371857-9	2015	DN inhibited the production of inflammatory mediators, such as inducible nitric oxide synthase (iNOS) and its derivative nitric oxide (NO), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), IL-1beta, IL-6 and TNF-alpha and H3 protein acetylation in murine peritoneal macrophages.	desoxonarchinol A	0-2	interleukin 1 beta	Mus musculus	191-199
26178478-6	2015	OSR-treated group (250 mg/kg) markedly reduced the inflammatory-related protein prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interleukin-8 (IL-8).	oxysophoridine	0-3	interleukin 1 beta	Mus musculus	165-173
26432179-9	2015	Our results showed that treatment of linalool significantly attenuated CS-induced lung inflammation, coupled with inhibited the infiltration of inflammatory cells and TNF-alpha, IL-6, IL-1beta, IL-8 and MCP-1 production.	linalool	37-45	interleukin 1 beta	Mus musculus	184-192
26590113-9	2015	Formalin-injected paws of mice treated with EOCO revealed the down-regulated expression of tumor necrosis factor-alpha, interleukin-1beta, inducible nitric oxide synthase, and cyclooxygenase-2, as compared with those of control mice.	Formaldehyde	0-8	interleukin 1 beta	Mus musculus	120-137
26514300-7	2015	Moreover, OA treatment inhibited DSS-induced expression of tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-17, the activation of NF-kappaB and mitogen-activated protein kinases, and increased IL-10 expression.	dss	33-36	interleukin 1 beta	Mus musculus	88-110
26590117-5	2015	Melatonin also inhibited LPS-induced inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) production in mammary tissues.	Melatonin	0-9	interleukin 1 beta	Mus musculus	101-118
26490221-11	2015	The production of IL-1beta, IL-6, and TNF-alpha decreased after being treated with GTS-21 in LPS-stimulated RAW 264.7 cells.	3-(2,4-dimethoxybenzylidene)anabaseine	83-89	interleukin 1 beta	Mus musculus	18-26
26734588-12	2015	The level of IL-1beta in DSS mice was much higher than control group (P &lt; 0.01), but there was no difference among several DSS groups.	dss	25-28	interleukin 1 beta	Mus musculus	13-21
26081624-0	2015	Bisphosphonate Induces Osteonecrosis of the Jaw in Diabetic Mice via NLRP3/Caspase-1-Dependent IL-1beta Mechanism.	Diphosphonates	0-14	interleukin 1 beta	Mus musculus	95-103
26081624-8	2015	Systemic treatment of mice with zoledronate (Zol), a nitrogen-containing bisphosphonate, resulted in a 1.86- and 1.63-fold increase in NLRP3/caspase-1-dependent IL-1beta secretion by db/+ and db/db BMDMs, respectively, compared with BMDMs derived from nontreated mice (p &lt; 0.001).	Zoledronic Acid	32-43	interleukin 1 beta	Mus musculus	161-169
26081624-8	2015	Systemic treatment of mice with zoledronate (Zol), a nitrogen-containing bisphosphonate, resulted in a 1.86- and 1.63-fold increase in NLRP3/caspase-1-dependent IL-1beta secretion by db/+ and db/db BMDMs, respectively, compared with BMDMs derived from nontreated mice (p &lt; 0.001).	Zoledronic Acid	45-48	interleukin 1 beta	Mus musculus	161-169
26081624-8	2015	Systemic treatment of mice with zoledronate (Zol), a nitrogen-containing bisphosphonate, resulted in a 1.86- and 1.63-fold increase in NLRP3/caspase-1-dependent IL-1beta secretion by db/+ and db/db BMDMs, respectively, compared with BMDMs derived from nontreated mice (p &lt; 0.001).	Diphosphonates	73-87	interleukin 1 beta	Mus musculus	161-169
26590117-5	2015	Melatonin also inhibited LPS-induced inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) production in mammary tissues.	Melatonin	0-9	interleukin 1 beta	Mus musculus	120-128
26519528-6	2015	Treatment of mice with HDACi in a dextran sodium sulfate-induced colitis model resulted in a strong increase in intestinal IL-1beta, confirming that this pathway is also operative in vivo.	hdaci	23-28	interleukin 1 beta	Mus musculus	123-131
26370610-13	2015	However, expression of interleukin-1 beta was significantly decreased by the 10% glycerol treatment, while expression of tumour necrosis factor-alpha decreased upon the same treatment, as well as in response to xylitol.	Glycerol	81-89	interleukin 1 beta	Mus musculus	23-41
26519528-6	2015	Treatment of mice with HDACi in a dextran sodium sulfate-induced colitis model resulted in a strong increase in intestinal IL-1beta, confirming that this pathway is also operative in vivo.	dextran sodium sulfate	34-56	interleukin 1 beta	Mus musculus	123-131
26491118-12	2015	Furthermore, mice fed cellulose+DSS exhibited 1.42, 11.5, 8.48, and 35.5 times greater (P &lt; 0.05) colon mRNA expression of tumor necrosis factor alpha (Tnfa) and interleukin (Il) 1b, Il6, and Il17a, respectively, and 7.10 times greater (P &lt; 0.05) expression of C-X-C motif ligand 1 (Cxc1) compared with mice fed PF+DSS.	Cellulose	22-31	interleukin 1 beta	Mus musculus	165-184
26491118-12	2015	Furthermore, mice fed cellulose+DSS exhibited 1.42, 11.5, 8.48, and 35.5 times greater (P &lt; 0.05) colon mRNA expression of tumor necrosis factor alpha (Tnfa) and interleukin (Il) 1b, Il6, and Il17a, respectively, and 7.10 times greater (P &lt; 0.05) expression of C-X-C motif ligand 1 (Cxc1) compared with mice fed PF+DSS.	dss	32-35	interleukin 1 beta	Mus musculus	165-184
26454213-5	2015	And these ameliorative effects of GE treatment were involved with regulating CUMS-induced pro-inflammatory cytokine interleukin-1 beta (IL-1beta) related neuro-inflammation.	cums	77-81	interleukin 1 beta	Mus musculus	116-134
26407722-10	2015	KO TI/R mice, WT TI/R BAY 11-7082, and Brilliant Blue G treated mice showed a significant reduced IL-1beta and IL-18 mRNA expression, blunted caspase-1 and -3 expression, minor histologic damages, low terminal deoxynucleotidyl transferase-mediated digoxigenin-deoxyuridine nick-end labeling activity, and preserved spermatogenesis.	brilliant blue	39-53	interleukin 1 beta	Mus musculus	98-106
26839505-7	2015	Fomentariol effectively suppressed the production of interleukin-1beta and interleukin-6 but not tumor necrosis factor-alpha.	Fomentariol	0-11	interleukin 1 beta	Mus musculus	53-70
26839505-8	2015	The inhibitory effect of fomentariol against nitric oxide, interleukin-1beta, and interleukin-6 production was possibly mediated by downregulation of the extracellular signal-regulated kinase signaling pathway.	Fomentariol	25-36	interleukin 1 beta	Mus musculus	59-76
26361726-11	2015	Western blot analysis confirmed the increased protein expression of IL-1beta, TNF-alpha and NF-kappaB p65 in the LPS group and treatment of animals with diosmin reversed these effects.	Diosmin	153-160	interleukin 1 beta	Mus musculus	68-76
26454213-5	2015	And these ameliorative effects of GE treatment were involved with regulating CUMS-induced pro-inflammatory cytokine interleukin-1 beta (IL-1beta) related neuro-inflammation.	cums	77-81	interleukin 1 beta	Mus musculus	136-144
26454213-6	2015	We further found that GE treatment reversed CUMS-induced IL-1beta elevation, possibly by inhibiting nuclear factor kappa B (NF-kappaB) pathway activation and regulating nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome expression.	cums	44-48	interleukin 1 beta	Mus musculus	57-65
26037299-7	2015	Resveratrol administration abolished LPS-induced elevation of tumor necrosis factor alpha (TNF-alpha) and interleukin (IL) 1beta but not IL-6 levels.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	106-128
26037299-9	2015	Resveratrol treatment suppressed the elevation in TNF-alpha and IL-1beta levels in LPS-exposed peritoneal macrophages.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	64-72
26265456-0	2015	Pathological concentrations of homocysteine increases IL-1beta production in macrophages in a P2X7, NF-kB, and erk-dependent manner.	Homocysteine	31-43	interleukin 1 beta	Mus musculus	54-62
26265456-5	2015	The purpose of the present study is to investigate the effects of Hcy on IL-1beta secretion by murine macrophages.	Homocysteine	66-69	interleukin 1 beta	Mus musculus	73-81
26265456-6	2015	Hcy (100 muM) increases IL-1beta synthesis via enhancement of P2X7 expression and NF-kB and ERK activation in murine macrophages.	Homocysteine	0-3	interleukin 1 beta	Mus musculus	24-32
26265456-7	2015	In addition, the antioxidant agent N-acetylcysteine (NAC) reduces NF-kappaB activation, ERK phosphorylation, and IL-1beta production in Hcy-exposed macrophages, indicating the importance of ROS in this pro-inflammatory process.	Acetylcysteine	35-51	interleukin 1 beta	Mus musculus	113-121
26265456-7	2015	In addition, the antioxidant agent N-acetylcysteine (NAC) reduces NF-kappaB activation, ERK phosphorylation, and IL-1beta production in Hcy-exposed macrophages, indicating the importance of ROS in this pro-inflammatory process.	Acetylcysteine	53-56	interleukin 1 beta	Mus musculus	113-121
26615818-2	2015	In vitro, LPS-induced nitric oxide (NO) production was significantly inhibited by MBF extracts via suppressing the expression of proinflammatory molecules, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1 beta (IL-beta) and IL-6.	Nitric Oxide	22-34	interleukin 1 beta	Mus musculus	232-250
26404052-11	2015	CPZ induced an increase in the expression of GFAP, IL-1beta TNF-alpha, total NFkB and inactive AMPK, and prompt microglia activation.	Cuprizone	0-3	interleukin 1 beta	Mus musculus	51-59
26664261-7	2015	Furthermore, liver LPL and liver PPAR-alpha were increased whereas IL-1beta and TNF-alpha were decreased in streptozotocin-injected mice treated with EGb 761 compared to mice injected with streptozotocin alone.	Streptozocin	108-122	interleukin 1 beta	Mus musculus	67-75
26456657-4	2015	Furthermore, disrupting the ATP-driven interaction by knocking-out P2X4R provoked an attenuation of P2X7-induced cell death, dye uptake and IL-1beta release in macrophages.	Adenosine Triphosphate	28-31	interleukin 1 beta	Mus musculus	140-148
26404052-13	2015	The administration of sildenafil reduced the expression of the pro-inflammatory cytokines IL-1beta and TNF-alpha and increased the expression of the anti-inflammatory cytokine IL-10.	Sildenafil Citrate	22-32	interleukin 1 beta	Mus musculus	90-98
24914072-0	2015	Gadolinium-based compounds induce NLRP3-dependent IL-1beta production and peritoneal inflammation.	Gadolinium	0-10	interleukin 1 beta	Mus musculus	50-58
26584539-8	2015	In LPS-primed macrophages, Citral reduced ATP-induced IL-1beta secretion and caspase-1 activation, but did not affect LPS-induced NLRP3 protein expression.	citral	27-33	interleukin 1 beta	Mus musculus	54-62
26584539-8	2015	In LPS-primed macrophages, Citral reduced ATP-induced IL-1beta secretion and caspase-1 activation, but did not affect LPS-induced NLRP3 protein expression.	Adenosine Triphosphate	42-45	interleukin 1 beta	Mus musculus	54-62
26593910-6	2015	We demonstrated that brazilein decreased the expression of IRAK4 protein led to the suppression of MAPK signaling and IKKbeta, and subsequent inactivation of NF-kappaB and COX2 thus promoting the expression of the downstream target pro-inflammatory cytokines such as IL-1beta, MCP-1, MIP-2, and IL-6 in LPS-induced Raw264.7 macrophage cells.	brazilein	21-30	interleukin 1 beta	Mus musculus	267-275
26453128-5	2015	In addition, KA-induced activations of microglia and astrocytes as well as KA-induced increases of TNF-alpha and IL-1beta levels were also suppressed by DXT treatment.	Duloxetine Hydrochloride	153-156	interleukin 1 beta	Mus musculus	113-121
26584539-5	2015	The analysis of mechanisms of action of Citral also involved its effects on IL-1beta secretion and signaling pathways of NLRP3 inflammasome in LPS-primed peritoneal macrophages or J774A macrophages.	citral	40-46	interleukin 1 beta	Mus musculus	76-84
26610528-7	2015	In addition, phorbaketal A reduced the LPS-induced production of inflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and monocyte chemotactic protein-1.	phorbaketal A	13-26	interleukin 1 beta	Mus musculus	125-147
26561804-5	2015	Additionally, ELISA showed that the serum levels of IFN-gamma, TNF-alpha, IL-12, IL-6, and IL-1beta were down-regulated in a TNBS model of colitis.	Trinitrobenzenesulfonic Acid	125-129	interleukin 1 beta	Mus musculus	91-99
26336925-6	2015	Intestinal tissues of infected vitamin D3-deficient mice displayed increased inflammatory cell infiltrates as well as significantly higher gene transcript levels of inflammatory mediators TNF-alpha, IL-1beta, IL-6, TGF-beta, IL-17A, and IL-17F as well as the antimicrobial peptide REG3gamma.	Cholecalciferol	31-41	interleukin 1 beta	Mus musculus	199-207
26374952-10	2015	Levels of IL-6, IL-1beta and IFN-gamma slightly increased on day 7 in mice treated with VACV combined with RAPA compared to VACV alone and then decreased on day 9.	Valacyclovir	88-92	interleukin 1 beta	Mus musculus	16-24
24914072-4	2015	Because other profibrotic agents, such as silica or asbestos, activate the nucleotide-binding oligomerisation domain (NOD)-like receptor protein 3 (NLRP3) inflammasome and initiate interleukin (IL)-1beta release with the subsequent development of fibrosis, we evaluated the effects of GBCAs on inflammasome activation.	Silicon Dioxide	42-48	interleukin 1 beta	Mus musculus	181-203
24914072-4	2015	Because other profibrotic agents, such as silica or asbestos, activate the nucleotide-binding oligomerisation domain (NOD)-like receptor protein 3 (NLRP3) inflammasome and initiate interleukin (IL)-1beta release with the subsequent development of fibrosis, we evaluated the effects of GBCAs on inflammasome activation.	Asbestos	52-60	interleukin 1 beta	Mus musculus	181-203
24914072-4	2015	Because other profibrotic agents, such as silica or asbestos, activate the nucleotide-binding oligomerisation domain (NOD)-like receptor protein 3 (NLRP3) inflammasome and initiate interleukin (IL)-1beta release with the subsequent development of fibrosis, we evaluated the effects of GBCAs on inflammasome activation.	gbcas	285-290	interleukin 1 beta	Mus musculus	181-203
26277481-9	2015	Quercetin also inhibited secretion of the inflammatory cytokines IL-1beta and IL-6 and stimulated that of IL-10, an antiinflammatory cytokine.	Quercetin	0-9	interleukin 1 beta	Mus musculus	65-73
26507910-6	2015	In addition, curcumin suppressed the production of inflammatory cytokines, such as TNF-alpha, IL-1beta, IL-6 and IL-8.	Curcumin	13-21	interleukin 1 beta	Mus musculus	94-102
26100496-7	2015	Depletion of uric acid or ATP, or lack of ATP signaling attenuated ASH and prevented inflammasome activation and its major downstream cytokine, IL-1beta.	Uric Acid	13-22	interleukin 1 beta	Mus musculus	144-152
26100496-7	2015	Depletion of uric acid or ATP, or lack of ATP signaling attenuated ASH and prevented inflammasome activation and its major downstream cytokine, IL-1beta.	Adenosine Triphosphate	42-45	interleukin 1 beta	Mus musculus	144-152
26100496-10	2015	CONCLUSIONS: Our data indicate that the second signal in inflammasome activation and IL-1beta production in ASH results from the endogenous danger signals, uric acid and ATP.	Uric Acid	156-165	interleukin 1 beta	Mus musculus	85-93
26100496-10	2015	CONCLUSIONS: Our data indicate that the second signal in inflammasome activation and IL-1beta production in ASH results from the endogenous danger signals, uric acid and ATP.	Adenosine Triphosphate	170-173	interleukin 1 beta	Mus musculus	85-93
26449522-11	2015	Cardiomyocytes and fibroblasts exposed to shed heparan sulfate-substituted syndecan-4 ectodomains showed increased Icam1, Vcam1, TNFalpha and IL-1beta expression and NF-kappaB-activation, suggesting direct regulation of immune cell recruitment pathways.	Heparitin Sulfate	47-62	interleukin 1 beta	Mus musculus	142-150
26300484-8	2015	We observed that pre-treatment with GW4869 significantly impaired release of both exosomes and pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) in RAW264.7 macrophages.	GW 4869	36-42	interleukin 1 beta	Mus musculus	134-142
26250869-7	2015	Furthermore, administration of curcumin significantly reduced peritoneal IL-1beta and HMGB-1 concentration induced by LPS and improved the survival of mice suffering from lethal endotoxic shock.	Curcumin	31-39	interleukin 1 beta	Mus musculus	73-81
26303871-5	2015	The leucine-metformin combinations reduced fat pad mass, normalized liver weight, liver and plasma lipids and inflammatory markers (interleukin 6, interleukin 1 beta, tumor necrosis factor alpha, monocyte chemotactic protein-1, C-reactive protein) comparable to the effects of therapeutic metformin.	Metformin	12-21	interleukin 1 beta	Mus musculus	147-194
26250869-3	2015	Here, we sought to investigate the role and mechanism of curcumin on the inhibition of mature IL-1beta production via the regulation of NLRP3 inflammasome.	Curcumin	57-65	interleukin 1 beta	Mus musculus	94-102
26246053-7	2015	Bosentan also inhibited superoxide anion-induced interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) production, while it enhanced IL-10 production in the paw skin and spinal cord.	Bosentan	0-8	interleukin 1 beta	Mus musculus	49-67
26250869-4	2015	METHODS AND RESULTS: Curcumin dramatically inhibited the production of mature IL-1beta in LPS-primed macrophages triggered by multiple NLRP3 inflammasome activators, and also reduced the level of cleaved caspase-1 as measured by western blot and ELISA.	Curcumin	21-29	interleukin 1 beta	Mus musculus	78-86
26282379-6	2015	Immuno-histopathological assays in CL lesions and quantitative mRNA studies in draining lymph nodes confirmed that beta-LP exhibited anti-inflammatory activity leading to the down-regulation of IL-1beta and COX-2 expression and a decrease of neutrophils infiltrate.	beta-lapachone	115-122	interleukin 1 beta	Mus musculus	194-202
26246053-7	2015	Bosentan also inhibited superoxide anion-induced interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) production, while it enhanced IL-10 production in the paw skin and spinal cord.	Bosentan	0-8	interleukin 1 beta	Mus musculus	69-77
26246053-7	2015	Bosentan also inhibited superoxide anion-induced interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) production, while it enhanced IL-10 production in the paw skin and spinal cord.	Superoxides	24-40	interleukin 1 beta	Mus musculus	49-67
26246053-7	2015	Bosentan also inhibited superoxide anion-induced interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) production, while it enhanced IL-10 production in the paw skin and spinal cord.	Superoxides	24-40	interleukin 1 beta	Mus musculus	69-77
26510880-4	2015	Cisplatin-mediated elevations in tumor necrosis factor alpha (TNF-alpha) mRNA, interleukin-1 beta (IL-1beta) mRNA, and cyclooxygenase-2 (COX-2) protein in the kidney were also significantly suppressed by QYG treatment.	Cisplatin	0-9	interleukin 1 beta	Mus musculus	79-97
26510880-4	2015	Cisplatin-mediated elevations in tumor necrosis factor alpha (TNF-alpha) mRNA, interleukin-1 beta (IL-1beta) mRNA, and cyclooxygenase-2 (COX-2) protein in the kidney were also significantly suppressed by QYG treatment.	Cisplatin	0-9	interleukin 1 beta	Mus musculus	99-107
26510947-7	2015	Impaired insulin sensitivity and glucose tolerance in aged T2DM mice were dramatically improved after long-term vglycin treatment, consistent with the altered level of inflammatory factor IL-1beta/6.	vglycin	112-119	interleukin 1 beta	Mus musculus	188-198
26498332-8	2015	Resveratrol administration slowed down NASH progression, decreased the levels of ALT, TG, TBARS, IL-1beta, IL-6, downregulated mRNA expressions of TNF-alpha, IL-1beta, IL-6, and regulated the expressions of proteins involved in autophagy, both in vitro and in vivo.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	97-105
26507386-8	2015	The mRNA expressions and protein levels of TNF-alpha, IL-1beta, IL-6, and IL-17A were significantly downregulated in dose-dependent manners in the nicotine treatment groups compared to the infected untreated group.	Nicotine	147-155	interleukin 1 beta	Mus musculus	54-62
26498332-8	2015	Resveratrol administration slowed down NASH progression, decreased the levels of ALT, TG, TBARS, IL-1beta, IL-6, downregulated mRNA expressions of TNF-alpha, IL-1beta, IL-6, and regulated the expressions of proteins involved in autophagy, both in vitro and in vivo.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	158-166
25867281-6	2015	Consistently, cathepsin B was found to proteolytically process pro-IL-1beta to its active form and this activity was suppressed by ROS.	Reactive Oxygen Species	131-134	interleukin 1 beta	Mus musculus	67-75
26114860-5	2015	However, pretreatment with donepezil inhibited MPP+-induced M1 polarization in microglia by suppressing the release of interleukin (IL)-6, IL-1beta, or tumor necrosis factor (TNF)-alpha.	Donepezil	27-36	interleukin 1 beta	Mus musculus	139-147
26114860-5	2015	However, pretreatment with donepezil inhibited MPP+-induced M1 polarization in microglia by suppressing the release of interleukin (IL)-6, IL-1beta, or tumor necrosis factor (TNF)-alpha.	mangion-purified polysaccharide (Candida albicans)	47-51	interleukin 1 beta	Mus musculus	139-147
25867281-8	2015	CONCLUSION: Our results suggest that ROS act as a negative feedback to constrain IL-1beta-mediated inflammation, accounting for the more severe arthritis in the absence of NOX2.	Reactive Oxygen Species	37-40	interleukin 1 beta	Mus musculus	81-89
26375251-5	2015	Treatment with atorvastatin along with imipenem reduced the lung bacterial load and pro-inflammatory cytokines (IL-1beta and TNFalpha) level in BALF.	Atorvastatin	15-27	interleukin 1 beta	Mus musculus	112-120
26297979-6	2015	Treatment with Herbacetin decreased the release of proinflammatory cytokines, including TNF-alpha and IL-1beta.	herbacetin	15-25	interleukin 1 beta	Mus musculus	102-110
26375251-5	2015	Treatment with atorvastatin along with imipenem reduced the lung bacterial load and pro-inflammatory cytokines (IL-1beta and TNFalpha) level in BALF.	Imipenem	39-47	interleukin 1 beta	Mus musculus	112-120
26297443-6	2015	GTN (10, 30 and 100mg/kg) inhibited leukocyte migration in the peritonitis model and gene expression levels of IL-1beta, iNOS and TNF-alpha, as well as TNF-alpha protein levels, in LPS-stimulated macrophages, without affecting COX-2 gene expression levels.	goniothalamin	0-3	interleukin 1 beta	Mus musculus	111-119
26468333-9	2015	The expression of IL-1beta by endothelial cells from TLR4 deficient mice under high glucose condition was decreased.	Glucose	84-91	interleukin 1 beta	Mus musculus	18-26
26101068-6	2015	The results showed that TM6 inhibited LPS-induced mammary gland histopathologic changes, MPO activity, and TNF-alpha, IL-1beta and IL-6 production in mice.	tm6	24-27	interleukin 1 beta	Mus musculus	118-126
26086368-6	2015	Results demonstrated that rifampicin pretreatment significantly reduced rotenone-induced cytotoxicity and gene expression of IL-1beta in BV2 microglia.	Rifampin	26-36	interleukin 1 beta	Mus musculus	125-133
26615372-13	2015	Suppression of TNF-alpha and IL-1beta could be another mechanism in pioglitazone-induced survival improving effect in septic mice.	Pioglitazone	68-80	interleukin 1 beta	Mus musculus	29-37
26086368-10	2015	Taken together, our data indicate that rifampicin pretreatment inhibits maturation of IL-1beta and neuroinflammation induced by rotenone via attenuating NLRP3 inflammasome activation.	Rifampin	39-49	interleukin 1 beta	Mus musculus	86-94
26086368-10	2015	Taken together, our data indicate that rifampicin pretreatment inhibits maturation of IL-1beta and neuroinflammation induced by rotenone via attenuating NLRP3 inflammasome activation.	Rotenone	128-136	interleukin 1 beta	Mus musculus	86-94
26516371-5	2015	The levels of IL-1beta and TNF-alpha were markedly increased in tumors colonized by DeltappGpp Salmonellae.	deltappgpp	84-94	interleukin 1 beta	Mus musculus	14-22
26112093-5	2015	WAR-5 also regulates the imbalance of Th1/Th17 T cells and regulatory T cells, inhibits inflammatory microenvironment induced with NF-kappaB-IL-1beta pathway.	war-5	0-5	interleukin 1 beta	Mus musculus	141-149
26234631-10	2015	Cinnamaldehyde suppressed the activation of signal transduction molecules including toll-like receptor 4, tumour necrosis receptor-associated factor 6 and NF-kappaB, attenuated the increased levels of TNF-alpha, IL-1beta, CCL2 and endothelial-leukocyte adhesion molecule-1 and ultimately reduced leukocyte infiltration into the ischaemic brain areas after cerebral ischaemia.	cinnamaldehyde	0-14	interleukin 1 beta	Mus musculus	212-220
25971983-10	2015	Furthermore, data showed that astaxanthin could decrease GFAP-positive cells in the brain and down-regulate the cleaved caspase-3, IL-6, and IL-1beta, and up-regulate CBS in the frontal cortex.	astaxanthine	30-41	interleukin 1 beta	Mus musculus	141-149
26147228-3	2015	IMQ-induced skin inflammation was partially reduced in mice deficient for both IL-1alpha/IL-1beta or for IL-1 receptor type 1 (IL-1R1), but not in IL-1alpha- or IL-1beta-deficient mice, demonstrating the redundant activity of IL-1alpha and IL-1beta for skin inflammation.	Imiquimod	0-3	interleukin 1 beta	Mus musculus	89-97
26321118-5	2015	Alpinetin also inhibited LPS-induced ROS, MDA, and inflammatory cytokines TNF-alpha, IL-6 and IL-1beta production in kidney tissues.	alpinetin	0-9	interleukin 1 beta	Mus musculus	94-102
26263169-12	2015	In addition, 6-gingerol suppressed DSS-elevated production of proinflammatory cytokines (IL-1beta, TNFalpha, and IL-12).	gingerol	13-23	interleukin 1 beta	Mus musculus	89-97
26263169-12	2015	In addition, 6-gingerol suppressed DSS-elevated production of proinflammatory cytokines (IL-1beta, TNFalpha, and IL-12).	dss	35-38	interleukin 1 beta	Mus musculus	89-97
26211495-8	2015	The results showed that pretreatment with Dex considerably reduced neutrophil infiltration and pulmonary edema, and significantly reduced protein concentrations in the BALF, as well as suppressed LPS-induced elevation of proinflammatory cytokines (TNF-alpha and IL-1beta) in the serum.	Dexmedetomidine	42-45	interleukin 1 beta	Mus musculus	262-270
26002587-3	2015	In the present study, we showed artesunate dose-dependently suppressed the lipopolysaccharide (LPS)-induced production of nitric oxide (NO), inducible nitric oxide synthase (iNOS), and interleukin-1beta (IL-1beta) in BV2 microglial cells.	Artesunate	32-42	interleukin 1 beta	Mus musculus	185-202
26002587-3	2015	In the present study, we showed artesunate dose-dependently suppressed the lipopolysaccharide (LPS)-induced production of nitric oxide (NO), inducible nitric oxide synthase (iNOS), and interleukin-1beta (IL-1beta) in BV2 microglial cells.	Artesunate	32-42	interleukin 1 beta	Mus musculus	204-212
26320672-4	2015	Protein and mRNA levels of DSS-induced pro-inflammatory cytokines in colon, including TNF-alpha, IL-1beta and IL-17A, were markedly suppressed by Fumigaclavine C.	Dextran Sulfate	27-30	interleukin 1 beta	Mus musculus	97-105
26452780-5	2015	In this study, we observed that paeonol exerted direct anticancer activity through inhibition of cell proliferation, induction of apoptosis, and evident anti-inflammatory effects by reducing proinflammatory cytokines secretion (TNF-alpha, IL-1beta, IL-6, and TGF-beta) in the conditioned medium of B16F10 mouse melanoma cells.	paeonol	32-39	interleukin 1 beta	Mus musculus	239-247
26059286-8	2015	RESULTS: Mesothelial cells exposed to either crocidolite or chrysotile underwent both apoptosis and necrosis and released cytokines IL-1beta, IL-6 and MIP-2.	Asbestos, Crocidolite	45-56	interleukin 1 beta	Mus musculus	132-140
26059286-10	2015	Neutralization of IL-1beta andIL-6, but not MIP-2, inhibited apoptosis and necrosis, especially in the cells exposed to crocidolite fibers.	Asbestos, Crocidolite	120-131	interleukin 1 beta	Mus musculus	18-34
26059286-11	2015	CONCLUSIONS: Both crocidolite and chrysotile asbestos fibers induced apoptosis and produced an acute inflammatory response characterized by elevated levels of IL-1beta, IL-6 and MIP-2 in cultured mouse PMC.	Asbestos, Crocidolite	18-29	interleukin 1 beta	Mus musculus	159-167
26059286-12	2015	IL-1beta and IL-6, but not MIP-2, were shown to contribute to asbestos-induced injury, especially in the crocidolite group.	Asbestos, Crocidolite	105-116	interleukin 1 beta	Mus musculus	0-8
26239044-3	2015	Enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction analyses demonstrated that K5-OS2 stimulated murine RAW264.7 macrophage cells to release TNF-alpha and IL-1beta proinflammatory cytokines.	k5-os2	113-119	interleukin 1 beta	Mus musculus	189-197
26623102-0	2015	Asiatic acid inhibits cardiac hypertrophy by blocking interleukin-1beta-activated nuclear factor-kappaB signaling in vitro and in vivo.	asiatic acid	0-12	interleukin 1 beta	Mus musculus	54-71
26623102-2	2015	This study investigated whether asiatic acid (AA) could inhibit IL-1beta-related hypertrophic signaling, and thus suppressing the development of cardiac hypertrophy.	asiatic acid	32-44	interleukin 1 beta	Mus musculus	64-72
26135269-7	2015	The expression of miR-92a was elevated in the chondrogenic ATDC5 cells and hADSCs, and also in the IL-1beta-induced ATDC5 cells, PMCs and PHCs.	N-[(2r)-3-(4-{[3-(4-Chlorophenyl)propanoyl]amino}phenyl)-1-(4-Methylpiperidin-1-Yl)-1-Oxopropan-2-Yl]-4-Methylpentanamide	22-25	interleukin 1 beta	Mus musculus	99-107
26135269-11	2015	These results demonstrated that miR-92a was involved in chondrogenesis and the chondrocyte response induced by IL-1beta.	mir-92a	32-39	interleukin 1 beta	Mus musculus	111-119
26320672-4	2015	Protein and mRNA levels of DSS-induced pro-inflammatory cytokines in colon, including TNF-alpha, IL-1beta and IL-17A, were markedly suppressed by Fumigaclavine C.	fumigaclavine C	146-161	interleukin 1 beta	Mus musculus	97-105
26320672-6	2015	Furthermore, in the LPS plus ATP cell model, we found that Fumigaclavine C dose-dependent inhibited IL-1beta release and caspase-1 activation.	Adenosine Triphosphate	29-32	interleukin 1 beta	Mus musculus	100-108
26320672-6	2015	Furthermore, in the LPS plus ATP cell model, we found that Fumigaclavine C dose-dependent inhibited IL-1beta release and caspase-1 activation.	fumigaclavine C	59-74	interleukin 1 beta	Mus musculus	100-108
26406888-12	2015	We also found TNF-alpha, IL-1beta and IL-6 mRNA expressions were up-regulated in intestinal mucositis tissues following 5-FU treatment (TNF-alpha: 4.35 vs. 1.18, IL-1beta: 2.29 vs. 1.07, IL-6: 1.49 vs. 1.02) and that probiotics treatment suppressed this up-regulation (P&lt;0.05).	Fluorouracil	120-124	interleukin 1 beta	Mus musculus	25-33
25849065-5	2015	Furthermore, we observed that CISCFE could obviously decrease UV-induced skin inflammation by inhibiting the production of inflammatory cytokines (interleukin-1beta [IL-1beta, IL-6, IL-10, tumor necrosis factor-alpha), alleviate the abnormal changes of anti-oxidative indicators (superoxide dismutase, catalase, and glutathione peroxidase), and down-regulate the levels of MMP-1 and MMP-3.	ciscfe	30-36	interleukin 1 beta	Mus musculus	147-164
25849065-5	2015	Furthermore, we observed that CISCFE could obviously decrease UV-induced skin inflammation by inhibiting the production of inflammatory cytokines (interleukin-1beta [IL-1beta, IL-6, IL-10, tumor necrosis factor-alpha), alleviate the abnormal changes of anti-oxidative indicators (superoxide dismutase, catalase, and glutathione peroxidase), and down-regulate the levels of MMP-1 and MMP-3.	ciscfe	30-36	interleukin 1 beta	Mus musculus	166-174
26408027-14	2015	TSA also reduced the expression of OA-associated proteins MMP1, MMP3, and MMP13 and proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6.	trichostatin A	0-3	interleukin 1 beta	Mus musculus	121-129
26406888-12	2015	We also found TNF-alpha, IL-1beta and IL-6 mRNA expressions were up-regulated in intestinal mucositis tissues following 5-FU treatment (TNF-alpha: 4.35 vs. 1.18, IL-1beta: 2.29 vs. 1.07, IL-6: 1.49 vs. 1.02) and that probiotics treatment suppressed this up-regulation (P&lt;0.05).	Fluorouracil	120-124	interleukin 1 beta	Mus musculus	162-170
26277391-4	2015	Furthermore, the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), nitric oxide (NO) and prostaglandin E2 (PGE2) induced by LPS was inhibited by DFO in RAW264.7 macrophages.	Deferoxamine	180-183	interleukin 1 beta	Mus musculus	72-89
26391752-9	2015	Furthermore, oxycodone decreased SNL-induced activation of glial cells (astrocytes and microglia) and plasma levels of proinflammatory cytokines (IL-6, IL-1beta and TNF-alpha).	Oxycodone	13-22	interleukin 1 beta	Mus musculus	152-160
26277391-4	2015	Furthermore, the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), nitric oxide (NO) and prostaglandin E2 (PGE2) induced by LPS was inhibited by DFO in RAW264.7 macrophages.	Deferoxamine	180-183	interleukin 1 beta	Mus musculus	91-99
26206858-9	2015	LX1606-treated mice had significantly lower MPO and IL-1beta levels compared with controls postinfection.	telotristat	0-6	interleukin 1 beta	Mus musculus	52-60
25531319-7	2015	Furthermore, serum interleukin (IL)-1beta and IL-6 levels were higher in PQ-exposed aged Casp2(-/-) mice indicating increased inflammation.	Primaquine	73-75	interleukin 1 beta	Mus musculus	19-41
26379247-8	2015	Mechanistically, SS-31 treatment suppressed pro-inflammatory responses by decreasing the levels of NF-kappaB, NLRP3, caspase 1, IL-1beta, and TNF-alpha; and inhibited the apoptotic pathway by decreasing the Bax/Bcl-2 ratio, reducing the release of cytochrome C, and blocking the cleavage of caspase 3.	arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide	17-22	interleukin 1 beta	Mus musculus	128-136
26054809-4	2015	Ginsenosides Rg1, Rh1, and 20(S)-protopanaxtriol inhibited the activation of NF-kappaB activation, phosphorylation of transforming growth factor beta-activated kinase 1 and interleukin (IL)-1 receptor-associated kinase, and expression of tumor necrosis factor-alpha and IL-1beta in lipopolysaccharide (LPS)-stimulated macrophages.	2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone	18-21	interleukin 1 beta	Mus musculus	270-278
26370415-8	2015	We find that harpagoside could scavenge hypoxia-enhanced inflammatory genes expression (COX-2, IL-1beta and IL-6 genes) and NO synthesis of microglial cells.	harpagoside	13-24	interleukin 1 beta	Mus musculus	95-103
26054809-4	2015	Ginsenosides Rg1, Rh1, and 20(S)-protopanaxtriol inhibited the activation of NF-kappaB activation, phosphorylation of transforming growth factor beta-activated kinase 1 and interleukin (IL)-1 receptor-associated kinase, and expression of tumor necrosis factor-alpha and IL-1beta in lipopolysaccharide (LPS)-stimulated macrophages.	protopanaxtriol	27-48	interleukin 1 beta	Mus musculus	270-278
26054809-6	2015	Orally administered ginsenoside Rg1, Rh1, or 20(S)-protopanaxtriol inhibited 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colon shortening, myeloperoxidase activity, and expression of IL-1beta, IL-17, and tumor necrosis factor-alpha in mice with TNBS-induced colitis.	2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone	37-40	interleukin 1 beta	Mus musculus	190-198
26054809-6	2015	Orally administered ginsenoside Rg1, Rh1, or 20(S)-protopanaxtriol inhibited 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colon shortening, myeloperoxidase activity, and expression of IL-1beta, IL-17, and tumor necrosis factor-alpha in mice with TNBS-induced colitis.	protopanaxtriol	47-66	interleukin 1 beta	Mus musculus	190-198
26054809-6	2015	Orally administered ginsenoside Rg1, Rh1, or 20(S)-protopanaxtriol inhibited 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colon shortening, myeloperoxidase activity, and expression of IL-1beta, IL-17, and tumor necrosis factor-alpha in mice with TNBS-induced colitis.	Trinitrobenzenesulfonic Acid	77-112	interleukin 1 beta	Mus musculus	190-198
26054809-6	2015	Orally administered ginsenoside Rg1, Rh1, or 20(S)-protopanaxtriol inhibited 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colon shortening, myeloperoxidase activity, and expression of IL-1beta, IL-17, and tumor necrosis factor-alpha in mice with TNBS-induced colitis.	Trinitrobenzenesulfonic Acid	114-118	interleukin 1 beta	Mus musculus	190-198
26100520-6	2015	Combined treatment with ursolic acid + resveratrol resulted in a greater inhibition of expression of proinflammatory cytokines, including Il1a, Il1b, and Il22.	ursolic acid	24-36	interleukin 1 beta	Mus musculus	144-148
26335138-8	2015	Swainsonine significantly increased IL-1beta, IFN-gamma and TNF-alpha nuclear translocation and decreased IL-4 and IL-10.	Swainsonine	0-11	interleukin 1 beta	Mus musculus	36-44
25944053-10	2015	miR-155 deficiency on DCs was also associated with impaired purinergic receptor signaling, as miR-155(-/-) DCs showed reduced chemotaxis and IL-1beta secretion upon stimulation with ATP, probably due to direct targeting of ectonucleoside triphosphate diphosphohydrolases (ENTPD) by miR-155.	Adenosine Triphosphate	182-185	interleukin 1 beta	Mus musculus	141-149
26344074-8	2015	RESULTS: The activation of LXRs by GW3965 significantly attenuated the production of IL-1alpha and IL-1beta, but not of IL-6, in the WT and LXRalpha(-/-) BMMCs stimulated with IgE+Ag.	GW 3965	35-41	interleukin 1 beta	Mus musculus	99-107
26344074-10	2015	CONCLUSIONS: These findings demonstrate, for the first time, that the activation of LXRs by GW3965 attenuates the antigen- or LPS-induced production of pro-inflammatory cytokines, such as IL-1alpha and IL-1beta, in murine MCs and that LXRbeta plays an important role in the LXR-mediated repression of cytokine production.	GW 3965	92-98	interleukin 1 beta	Mus musculus	202-210
26100520-6	2015	Combined treatment with ursolic acid + resveratrol resulted in a greater inhibition of expression of proinflammatory cytokines, including Il1a, Il1b, and Il22.	Resveratrol	39-50	interleukin 1 beta	Mus musculus	144-148
26054366-5	2015	Infusing wild-type mice with aldosterone (0.25 mg/kg/d) caused tubulointerstitial damage, increased expression of inflammasome components, caspase 1 activation, and overproduction of IL-1beta and IL-18.	Aldosterone	29-40	interleukin 1 beta	Mus musculus	183-191
25998196-16	2015	Moreover, nuclear factor-kappaB activation, concentrations of the inflammatory cytokines tumour necrosis factor-alpha and interleukin-1beta and oxidative stress were increased in the skeletal muscle from DM mice and inhibited in DM+Curcumin mice.	Curcumin	232-240	interleukin 1 beta	Mus musculus	122-139
26032634-7	2015	Tubular cell death by cisplatin led to pro-inflammatory response by production of TNFalpha and IL1beta followed by leukocyte/neutrophil infiltration which resulted in new wave of ROS involving more NADPH oxidases.	Cisplatin	22-31	interleukin 1 beta	Mus musculus	95-102
26065856-8	2015	Similarly, SIRT1 activators (CAY10591: IC50 ~ 10 muM, resveratrol: IC50 ~ 5 muM) or prostacyclin analogs (IC50 ~ 5 muM) prevented SIRT1 inhibition and reduced TF induced by CSE/IL-1beta or by PGE2.	CAY10591	29-37	interleukin 1 beta	Mus musculus	177-185
26069075-8	2015	Furthermore, SP600125, an inhibitor of JNK, significantly blocked the upregulation of Angptl4 by IL-1beta.	pyrazolanthrone	13-21	interleukin 1 beta	Mus musculus	97-105
25880604-0	2015	Interleukin-1beta protects astrocytes against oxidant-induced injury via an NF-kappaB-dependent upregulation of glutathione synthesis.	Glutathione	112-123	interleukin 1 beta	Mus musculus	0-17
26190278-8	2015	The amount of pro-inflammatory cytokines, specifically TNF-alpha, IL-1beta and IL-6 and the activity of myeloperoxidase in colon tissue were significantly decreased in geraniol pre-treated mice.	geraniol	168-176	interleukin 1 beta	Mus musculus	66-74
25880604-2	2015	Previously, we found that interleukin-1beta (IL-1beta) enhanced the expression of astrocyte system xc (-) , the transporter that delivers the rate-limiting substrate for GSH synthesis-cyst(e)ine.	Glutathione	170-173	interleukin 1 beta	Mus musculus	26-43
26115075-6	2015	In cultured cells, endogenous GPx2 expression and GPx2 promoter activity were enhanced by the anti-inflammatory mediators 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) and interleukin-22 (IL-22), while it was unaffected by classical proinflammatory cytokines like IL-1beta.	15-deoxy-delta	122-136	interleukin 1 beta	Mus musculus	268-276
25959240-6	2015	Furthermore, neutrophil depletion during the elicitation phase of OXA-induced contact dermatitis also caused significant decreases in ear swelling and CD8(+) T-cell infiltration accompanied by significantly decreased LTB4 synthesis and gene expression of CXCL2, interferon-gamma and interleukin-1beta.	Oxazolone	66-69	interleukin 1 beta	Mus musculus	283-300
26253656-9	2015	H2 could suppress the release of cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and intercellular cell adhesion molecule-1 (ICAM-1), and pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and high-mobility group box 1 protein (HMGB1).	Hydrogen	0-2	interleukin 1 beta	Mus musculus	237-259
26166692-6	2015	We also found that insulin receptor substrate-1 (IRS-1), a component of insulin signaling, was negatively regulated by NLRP3 and IL-1beta, and that IL-1beta inhibited insulin-induced glucose uptake in myoblasts.	Glucose	183-190	interleukin 1 beta	Mus musculus	148-156
26166692-7	2015	These results suggest that PLIN2 inhibits insulin-induced glucose uptake by activating NLRP3, caspase-1 and IL-1beta, leading to a decreased IRS-1 expression.	Glucose	58-65	interleukin 1 beta	Mus musculus	108-116
25880604-2	2015	Previously, we found that interleukin-1beta (IL-1beta) enhanced the expression of astrocyte system xc (-) , the transporter that delivers the rate-limiting substrate for GSH synthesis-cyst(e)ine.	Glutathione	170-173	interleukin 1 beta	Mus musculus	45-53
25880604-3	2015	Herein, we demonstrate directly that IL-1beta mediates a time-dependent increase in extracellular GSH levels in cortical astrocyte cultures, suggesting both enhanced synthesis and export.	Glutathione	98-101	interleukin 1 beta	Mus musculus	37-45
25880604-6	2015	IL-1beta treatment prevented the increase in reactive oxygen species produced in astrocytes following tBOOH exposure.	Reactive Oxygen Species	45-68	interleukin 1 beta	Mus musculus	0-8
25880604-6	2015	IL-1beta treatment prevented the increase in reactive oxygen species produced in astrocytes following tBOOH exposure.	tert-Butylhydroperoxide	102-107	interleukin 1 beta	Mus musculus	0-8
25880604-7	2015	Additionally, the toxicity induced by tBOOH or FeSO4 exposure was significantly attenuated following treatment with IL-1beta, an effect reversed by concomitant exposure to l-buthionine-S,R-sulfoximine (BSO), which prevented the IL-1beta-mediated rise in GSH production.	tert-Butylhydroperoxide	38-43	interleukin 1 beta	Mus musculus	116-124
25880604-7	2015	Additionally, the toxicity induced by tBOOH or FeSO4 exposure was significantly attenuated following treatment with IL-1beta, an effect reversed by concomitant exposure to l-buthionine-S,R-sulfoximine (BSO), which prevented the IL-1beta-mediated rise in GSH production.	tert-Butylhydroperoxide	38-43	interleukin 1 beta	Mus musculus	228-236
25880604-7	2015	Additionally, the toxicity induced by tBOOH or FeSO4 exposure was significantly attenuated following treatment with IL-1beta, an effect reversed by concomitant exposure to l-buthionine-S,R-sulfoximine (BSO), which prevented the IL-1beta-mediated rise in GSH production.	ferrous sulfate	47-52	interleukin 1 beta	Mus musculus	116-124
25880604-7	2015	Additionally, the toxicity induced by tBOOH or FeSO4 exposure was significantly attenuated following treatment with IL-1beta, an effect reversed by concomitant exposure to l-buthionine-S,R-sulfoximine (BSO), which prevented the IL-1beta-mediated rise in GSH production.	ferrous sulfate	47-52	interleukin 1 beta	Mus musculus	228-236
25880604-7	2015	Additionally, the toxicity induced by tBOOH or FeSO4 exposure was significantly attenuated following treatment with IL-1beta, an effect reversed by concomitant exposure to l-buthionine-S,R-sulfoximine (BSO), which prevented the IL-1beta-mediated rise in GSH production.	l-buthionine-s	172-186	interleukin 1 beta	Mus musculus	116-124
25880604-7	2015	Additionally, the toxicity induced by tBOOH or FeSO4 exposure was significantly attenuated following treatment with IL-1beta, an effect reversed by concomitant exposure to l-buthionine-S,R-sulfoximine (BSO), which prevented the IL-1beta-mediated rise in GSH production.	l-buthionine-s	172-186	interleukin 1 beta	Mus musculus	228-236
25880604-7	2015	Additionally, the toxicity induced by tBOOH or FeSO4 exposure was significantly attenuated following treatment with IL-1beta, an effect reversed by concomitant exposure to l-buthionine-S,R-sulfoximine (BSO), which prevented the IL-1beta-mediated rise in GSH production.	r-sulfoximine	187-200	interleukin 1 beta	Mus musculus	116-124
25880604-7	2015	Additionally, the toxicity induced by tBOOH or FeSO4 exposure was significantly attenuated following treatment with IL-1beta, an effect reversed by concomitant exposure to l-buthionine-S,R-sulfoximine (BSO), which prevented the IL-1beta-mediated rise in GSH production.	r-sulfoximine	187-200	interleukin 1 beta	Mus musculus	228-236
25880604-7	2015	Additionally, the toxicity induced by tBOOH or FeSO4 exposure was significantly attenuated following treatment with IL-1beta, an effect reversed by concomitant exposure to l-buthionine-S,R-sulfoximine (BSO), which prevented the IL-1beta-mediated rise in GSH production.	Buthionine Sulfoximine	202-205	interleukin 1 beta	Mus musculus	116-124
25880604-7	2015	Additionally, the toxicity induced by tBOOH or FeSO4 exposure was significantly attenuated following treatment with IL-1beta, an effect reversed by concomitant exposure to l-buthionine-S,R-sulfoximine (BSO), which prevented the IL-1beta-mediated rise in GSH production.	Buthionine Sulfoximine	202-205	interleukin 1 beta	Mus musculus	228-236
25880604-7	2015	Additionally, the toxicity induced by tBOOH or FeSO4 exposure was significantly attenuated following treatment with IL-1beta, an effect reversed by concomitant exposure to l-buthionine-S,R-sulfoximine (BSO), which prevented the IL-1beta-mediated rise in GSH production.	Glutathione	254-257	interleukin 1 beta	Mus musculus	116-124
25880604-9	2015	Overall, our data indicate that under certain conditions IL-1beta may be an important stimulus for increasing astrocyte GSH production, and potentially, total antioxidant capacity in brain, via an NF-kappaB-dependent process.	Glutathione	120-123	interleukin 1 beta	Mus musculus	57-65
26152332-8	2015	NCA also inhibited the production of pro-inflammatory mediators, tumor necrosis factor-alpha and interleukin-1 beta.	5'-O-caffeoylquinic acid	0-3	interleukin 1 beta	Mus musculus	97-115
26180249-8	2015	Mice fed dextrin-based diets secreted 47-88% less colonic IL-1beta, tumor necrosis factor alpha, and IL-23 (SFD-t diet) and IL-12 heterodimer p70, IL-6, and chemokine ligand 1 (CXCL1) (SFD-c diet) (P &lt; 0.05) than did the control group, whereas NRS-fed mice secreted 55-77% less IL-6 and CXCL1 (P &lt; 0.05).	Dextrins	9-16	interleukin 1 beta	Mus musculus	58-66
26031312-4	2015	Our results indicated that SKF83959 significantly suppressed the expression/release of the pro-inflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS), and inhibited the generation of reactive oxygen species.	SK and F 83959	27-35	interleukin 1 beta	Mus musculus	168-185
26031312-4	2015	Our results indicated that SKF83959 significantly suppressed the expression/release of the pro-inflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS), and inhibited the generation of reactive oxygen species.	SK and F 83959	27-35	interleukin 1 beta	Mus musculus	187-195
26031312-10	2015	Our results indicated that SKF83959 enhanced the activity of endogenous dehydroepiandrosterone (DHEA) in a synergic manner, and inhibited the activation of BV2 microglia and the expression/release of the pro-inflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS).	SK and F 83959	27-35	interleukin 1 beta	Mus musculus	281-298
26031312-10	2015	Our results indicated that SKF83959 enhanced the activity of endogenous dehydroepiandrosterone (DHEA) in a synergic manner, and inhibited the activation of BV2 microglia and the expression/release of the pro-inflammatory mediators, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS).	SK and F 83959	27-35	interleukin 1 beta	Mus musculus	300-308
26094939-13	2015	Melatonin decreased the production of TNF-alpha, IL-1beta, and HMGB1.	Melatonin	0-9	interleukin 1 beta	Mus musculus	49-57
26251254-10	2015	DRD2 activation by quinpirole and ropinirole ameliorated neurological outcome, brain edema, interleukin-1beta, and monocyte chemoattractant protein-1 expression, as well as microglia/macrophages activation, in the perihematomal region.	Quinpirole	19-29	interleukin 1 beta	Mus musculus	92-109
26132854-10	2015	In a carrageenan-induced peritonitis model, gamma-terpinene treatment reduced neutrophil migration as well as the production of interleukin-1beta and tumor necrosis factor-alpha when compared to nontreated animals, and in the acute lung injury protocol, gamma-terpinene diminished the neutrophil migration into lung tissue independently of the total protein extravasation in the lung.	gamma-terpinene	44-59	interleukin 1 beta	Mus musculus	128-177
25998703-4	2015	The present study confirmed the anti-inflammatory effects of heparin in lipopolysaccharide (LPS)-induced murine peritoneal macrophages through decreasing the levels of the inflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), IL-8 and IL-1beta.	Heparin	61-68	interleukin 1 beta	Mus musculus	267-275
26251254-10	2015	DRD2 activation by quinpirole and ropinirole ameliorated neurological outcome, brain edema, interleukin-1beta, and monocyte chemoattractant protein-1 expression, as well as microglia/macrophages activation, in the perihematomal region.	ropinirole	34-44	interleukin 1 beta	Mus musculus	92-109
26343372-4	2015	ZOL and ALN mediated significant release of IL-6, TNF-` and IL-1beta, whereas they inhibited IL-10 secretion by osteoclasts.	Alendronate	8-11	interleukin 1 beta	Mus musculus	60-68
26071454-5	2015	Moreover, the increase in serum IL-1beta and IL-6 levels by the treatment of CBZ indicated the occurring of inflammation.	carbendazim	77-80	interleukin 1 beta	Mus musculus	32-40
26234731-5	2015	Subcutaneous injection of gallic acid or catechin significantly reduced MSU-induced IL-1beta and IL-6 secretion in C57BL/6 mice.	Gallic Acid	26-37	interleukin 1 beta	Mus musculus	84-92
26234731-5	2015	Subcutaneous injection of gallic acid or catechin significantly reduced MSU-induced IL-1beta and IL-6 secretion in C57BL/6 mice.	Catechin	41-49	interleukin 1 beta	Mus musculus	84-92
26302442-6	2015	SM supplementation significantly maintained covalently-bound omega-hydroxy ceramide levels and down-regulated mRNA levels of acute inflammation-associated genes, including thymic stromal lymphopoietin, interleukin-1 beta, and interleukin-6.	Sphingomyelins	0-2	interleukin 1 beta	Mus musculus	202-220
26049009-3	2015	The results showed that pinocembrin dose-dependently inhibited LPS-induced inflammatory mediators TNF-alpha, IL-1beta, NO and PGE2 production.	pinocembrin	24-35	interleukin 1 beta	Mus musculus	109-117
26284788-10	2015	Of these 5, adenosine was also lower in obese and in tumor-bearing mice (p&lt;0.05) and its concentration was inversely associated with colonic Il1b and Tnf production (p&lt;0.05).	Adenosine	12-21	interleukin 1 beta	Mus musculus	144-148
26312203-5	2015	Mice exposed to arsenic exhibited significant increased in TNF-alpha (4.3-fold), serum Interleukin-1 beta (threefold), Interleukin-6 (3.8-fold) as compared to controls.	Arsenic	16-23	interleukin 1 beta	Mus musculus	87-105
25975489-7	2015	The results showed that Sal B inhibited CS-induced lung pathological changes, the infiltration of inflammatory cells, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and monocyte chemoattractant protein 1 (MCP-1) productions.	salvianolic acid B	24-29	interleukin 1 beta	Mus musculus	181-198
25975489-7	2015	The results showed that Sal B inhibited CS-induced lung pathological changes, the infiltration of inflammatory cells, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and monocyte chemoattractant protein 1 (MCP-1) productions.	salvianolic acid B	24-29	interleukin 1 beta	Mus musculus	200-208
30338301-8	2015	IL-1beta secretion was analyzed by ELISA, mitochondrial function by JC-1 staining and ATP content.	Adenosine Triphosphate	86-89	interleukin 1 beta	Mus musculus	0-8
26100631-3	2015	Sustained stimulation (&gt;2 h) of LPS-primed caspase-1-deficient (Casp1/11(-/-)) BMDC with the canonical NLRP3 inflammasome agonist nigericin results in release of bioactive IL-1beta in conjunction with robust caspase-8 activation.	Nigericin	133-142	interleukin 1 beta	Mus musculus	175-183
30338301-0	2015	Cellulose nanocrystal cationic derivative induces NLRP3 inflammasome-dependent IL-1beta secretion associated with mitochondrial ROS production.	Cellulose	0-9	interleukin 1 beta	Mus musculus	79-87
26086863-9	2015	FC98 also dose-dependently inhibited IL-1beta secretion.	fc98	0-4	interleukin 1 beta	Mus musculus	37-45
26396668-0	2015	Mangiferin suppresses CIA by suppressing the expression of TNF-alpha, IL-6, IL-1beta, and RANKL through inhibiting the activation of NF-kappaB and ERK1/2.	mangiferin	0-10	interleukin 1 beta	Mus musculus	76-84
26086107-4	2015	In response to lipopolysaccharide (LPS), the reducing effect of 20(S)-Rg3 and 20(R)-Rg3 on nitric oxide led to an increase in the survival time of mice after lethal endotoxin-induced shock, and excess levels of NO inhibited IL-1beta production via the S-nitrosylation of the NLRP3 inflammasome.	Nitric Oxide	91-103	interleukin 1 beta	Mus musculus	224-232
30338301-0	2015	Cellulose nanocrystal cationic derivative induces NLRP3 inflammasome-dependent IL-1beta secretion associated with mitochondrial ROS production.	Reactive Oxygen Species	128-131	interleukin 1 beta	Mus musculus	79-87
26194345-9	2015	Treatment with ocotillol inhibited TNBS-induced expression of tumor necrosis factor (TNF)-alpha and IL-1beta, as well as activation of NF-kappaB and MAPKs.	ocotillol	15-24	interleukin 1 beta	Mus musculus	100-108
26194345-9	2015	Treatment with ocotillol inhibited TNBS-induced expression of tumor necrosis factor (TNF)-alpha and IL-1beta, as well as activation of NF-kappaB and MAPKs.	Trinitrobenzenesulfonic Acid	35-39	interleukin 1 beta	Mus musculus	100-108
25592072-8	2015	In addition, ethanol promotes interleukin-1beta (IL-1beta) secretion, and IL-1beta is a master cytokine regulating inflammatory response.	Ethanol	13-20	interleukin 1 beta	Mus musculus	30-47
26051275-5	2015	Interestingly, IL-1beta stimulated lactate production with increases in hexokinase II and lactate dehydrogenase expression and a decrease in pyruvate dehydrogenase.	Lactic Acid	35-42	interleukin 1 beta	Mus musculus	15-23
26051275-6	2015	Inhibition of lactate production restored IL-1beta-induced down-regulation of collagen1 and scleraxis expression.	Lactic Acid	14-21	interleukin 1 beta	Mus musculus	42-50
26051275-9	2015	These findings indicate that IL-1beta strongly and irreversibly impairs tenogenic potential and alters glucose metabolism in tendon progenitors appearing in injured tendons.	Glucose	103-110	interleukin 1 beta	Mus musculus	29-37
25985156-12	2015	In addition, immunohistochemical analysis and enzyme-linked immunosorbent assay showed icariin significantly reduced expression and secretion of tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 in the calvariae of titanium-stimulated mice.	icariin	87-94	interleukin 1 beta	Mus musculus	174-191
25917370-7	2015	Pharmacological inhibition of caspase-8 by z-IETD-FMK robustly reduced tumour outgrowth and this was closely associated with a reduction in the release of pro-inflammatory cytokines, IL-6, TNF-alpha, IL-18, IL-1alpha, IL-33, but not IL-1beta.	benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone	43-53	interleukin 1 beta	Mus musculus	233-241
25673209-2	2015	Interleukin-1beta (IL-1beta) elicits the expression of inflammatory mediators through a mechanism involving hyaluronan (HA) degradation, thereby contributing to toll-like receptor 4 (TLR-4) and CD44 activation.	Hyaluronic Acid	108-118	interleukin 1 beta	Mus musculus	0-17
25673209-2	2015	Interleukin-1beta (IL-1beta) elicits the expression of inflammatory mediators through a mechanism involving hyaluronan (HA) degradation, thereby contributing to toll-like receptor 4 (TLR-4) and CD44 activation.	Hyaluronic Acid	108-118	interleukin 1 beta	Mus musculus	19-27
25673209-2	2015	Interleukin-1beta (IL-1beta) elicits the expression of inflammatory mediators through a mechanism involving hyaluronan (HA) degradation, thereby contributing to toll-like receptor 4 (TLR-4) and CD44 activation.	Hyaluronic Acid	120-122	interleukin 1 beta	Mus musculus	0-17
25912802-6	2015	In addition, treatment with honokiol significantly decreased the protein and mRNA levels of interleukin (IL)-1beta and the activity of acetylcholinesterase (AChE), while significantly increased the protein and mRNA levels of IL-10, and the level of acetylcholine (Ach) in the brain of the SCOP-treated mice.	honokiol	28-36	interleukin 1 beta	Mus musculus	92-114
25989136-3	2015	EXPERIMENTAL APPROACH: We measured IL-1beta in colon-conditioned media (CM) from acute (AC-CM, dextran sodium sulfate) and chronic (CC-CM, T-cell transfer) colitis-induced mice and corresponding controls (Con-AC/CC-CM).	dextran sodium sulfate	95-117	interleukin 1 beta	Mus musculus	35-43
25673209-2	2015	Interleukin-1beta (IL-1beta) elicits the expression of inflammatory mediators through a mechanism involving hyaluronan (HA) degradation, thereby contributing to toll-like receptor 4 (TLR-4) and CD44 activation.	Hyaluronic Acid	120-122	interleukin 1 beta	Mus musculus	19-27
25592072-8	2015	In addition, ethanol promotes interleukin-1beta (IL-1beta) secretion, and IL-1beta is a master cytokine regulating inflammatory response.	Ethanol	13-20	interleukin 1 beta	Mus musculus	49-57
25592072-9	2015	Importantly, ethanol-promoted IL-1beta secretion is inhibited in the developing cerebellum of N-PKR-/- mice.	Ethanol	13-20	interleukin 1 beta	Mus musculus	30-38
25957741-8	2015	Moreover, quercetin decreased production of pro-inflammatory markers including TNF-alpha, IL-1beta and iNOS.	Quercetin	10-19	interleukin 1 beta	Mus musculus	90-98
25845418-12	2015	Increased apoptosis upon ABT-737 was determined in blood lymphocytes, splenocytes and Peyer"s patches and was accompanied by a decrease in TNF and IL-1B.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	25-28	interleukin 1 beta	Mus musculus	147-152
26096304-8	2015	In addition, 30 min after intrahippocampal injection of 4-aminopyridine, IL-1beta increased the incidence of SE, while IL-1RA prolonged the intervals between recurrent seizures.	4-Aminopyridine	56-71	interleukin 1 beta	Mus musculus	73-81
26047769-11	2015	Within the brain, a similar pattern was seen in gene expression in the hippocampus at 4h for Il-10 and Ifn-gamma, however norquetiapine led to an increase in Il-1beta expression in the PFC at 4h, while both drugs attenuated the increased Il-10 in different regions of the brain at 24h.	norquetiapine	122-135	interleukin 1 beta	Mus musculus	158-166
26464629-9	2015	LMWH attenuated LPS-induced hippocampus-dependent cognitive impairments, which was accompanied by decreased hippocampal IL-1beta, malondialdehyde, Toll-like receptor 4, nuclear factor kappa B p65, inducible nitric oxide synthase, cyclooxygenase-2, high mobility group box-1 protein, and IBA1 positive cells, and increased occluding and brain derived neurotrophic factor levels.	Heparin, Low-Molecular-Weight	0-4	interleukin 1 beta	Mus musculus	120-128
25993999-6	2015	In addition, circulating levels and pancreatic mRNA of the inflammatory cytokines tumor necrosis factor-alpha, interleukin Il-1beta, and Il-6 were reduced in TPPU-treated mice.	TPPU	158-162	interleukin 1 beta	Mus musculus	123-131
25633425-6	2015	Furthermore, AA significantly reduced PQ-induced upregulations of inflammatory mediators such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8.	Paraquat	38-40	interleukin 1 beta	Mus musculus	132-154
25747604-7	2015	We found l-serine treatment: 1) decreased the neurological deficit score, brain water content, lesion volume, and neurone loss; 2) inhibited activated caspase-3; and 3) reduced the levels of TNF-alpha, IL-1beta and IL-6 and the number of GFAP- and Iba-1-positive cells.	Serine	9-17	interleukin 1 beta	Mus musculus	202-210
26447625-6	2015	Tunicamycin significantly enhanced the LPS-induced up-regulation of TNFa, IL-6 and IL-1b expression (TNFa, 1.44+/-0.38, t=2.8, P&lt;0.05; IL-1b, 16.063.40, t =7.93, P&lt;0.05; IL-6, 31.1610.60, t=5.08, P&lt;0.05).	Tunicamycin	0-11	interleukin 1 beta	Mus musculus	83-88
25891417-8	2015	Casticin and chrysosplenol D suppressed LPS-induced release of IL-1 beta, IL-6 and MCP-1, inhibited cell migration, and reduced LPS-induced IkappaB and c-JUN phosphorylation in Raw264.7 cells.	casticin	0-8	interleukin 1 beta	Mus musculus	63-72
25891417-8	2015	Casticin and chrysosplenol D suppressed LPS-induced release of IL-1 beta, IL-6 and MCP-1, inhibited cell migration, and reduced LPS-induced IkappaB and c-JUN phosphorylation in Raw264.7 cells.	Chrysosplenol C	13-26	interleukin 1 beta	Mus musculus	63-72
26447625-6	2015	Tunicamycin significantly enhanced the LPS-induced up-regulation of TNFa, IL-6 and IL-1b expression (TNFa, 1.44+/-0.38, t=2.8, P&lt;0.05; IL-1b, 16.063.40, t =7.93, P&lt;0.05; IL-6, 31.1610.60, t=5.08, P&lt;0.05).	Tunicamycin	0-11	interleukin 1 beta	Mus musculus	138-143
26230326-4	2015	Administration of allopurinol resulted in a statistically significant decrease in IL-1beta and TNF-alpha mRNA expression, whereas febuxostat had no significant effect on expression of these genes; nevertheless, both inhibitors effectively reduced serum uric acid concentration.	Allopurinol	18-29	interleukin 1 beta	Mus musculus	82-90
26252187-6	2015	The septic mice treated with AICAR exhibited elevated phosphorylation of AMPKalpha in the brain along with reduced serum levels of aspartate aminotransferase, tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6), compared with the vehicle.	AICA ribonucleotide	29-34	interleukin 1 beta	Mus musculus	200-217
26252187-6	2015	The septic mice treated with AICAR exhibited elevated phosphorylation of AMPKalpha in the brain along with reduced serum levels of aspartate aminotransferase, tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6), compared with the vehicle.	AICA ribonucleotide	29-34	interleukin 1 beta	Mus musculus	219-227
26252187-7	2015	Similarly, the expressions of TNF-alpha, IL-1beta, keratinocyte-derived chemokine and macrophage inflammatory protein-2 as well as myeloperoxidase activity in the lungs of AICAR-treated mice were significantly reduced.	AICA ribonucleotide	172-177	interleukin 1 beta	Mus musculus	41-49
25980587-6	2015	Vinpocetine (30mg/kg) significantly reduces hyperalgesia to mechanical and thermal stimuli, and myeloperoxidase (MPO) activity (a neutrophil marker) in the plantar paw skin, and also inhibits neutrophil and mononuclear cell recruitment, superoxide anion and nitric oxide production, oxidative stress, and cytokine production (TNF-alpha, IL-1beta and IL-33) in the peritoneal cavity.	vinpocetine	0-11	interleukin 1 beta	Mus musculus	337-345
26221081-7	2015	Treatment with calipteryxin and (3"S,4"S)-3",4"-disenecioyloxy-3",4"-dihydroseselin also decreased the production of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) in a dose-dependent manner.	Calipteryxin	15-27	interleukin 1 beta	Mus musculus	180-198
26221081-7	2015	Treatment with calipteryxin and (3"S,4"S)-3",4"-disenecioyloxy-3",4"-dihydroseselin also decreased the production of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) in a dose-dependent manner.	Calipteryxin	15-27	interleukin 1 beta	Mus musculus	200-208
26221081-7	2015	Treatment with calipteryxin and (3"S,4"S)-3",4"-disenecioyloxy-3",4"-dihydroseselin also decreased the production of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) in a dose-dependent manner.	(3"s,4"s)-3",4"-disenecioyloxy-3",4"-dihydroseselin	32-83	interleukin 1 beta	Mus musculus	180-198
26221081-7	2015	Treatment with calipteryxin and (3"S,4"S)-3",4"-disenecioyloxy-3",4"-dihydroseselin also decreased the production of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) in a dose-dependent manner.	(3"s,4"s)-3",4"-disenecioyloxy-3",4"-dihydroseselin	32-83	interleukin 1 beta	Mus musculus	200-208
25980587-7	2015	At least in part, these effects seem to be mediated by direct effects of vinpocetine on macrophages, since it inhibited the production of the same cytokines (TNF-alpha, IL-1beta and IL-33) and the NF-kappaB activation in LPS-stimulated RAW 264.7 macrophages.	vinpocetine	73-84	interleukin 1 beta	Mus musculus	169-177
26154512-6	2015	The intraperitoneal treatment with naringenin reduced skin inflammation by inhibiting skin edema, neutrophil recruitment, MMP-9 activity, and pro-inflammatory (TNF-alpha, IFN-gamma, IL-1beta, IL-4, IL-5, IL-6, IL-12, IL-13, IL-17, IL-22, and IL-23) and anti-inflammatory (TGF-beta and IL-10) cytokines.	naringenin	35-45	interleukin 1 beta	Mus musculus	182-190
26204936-10	2015	PF administration inhibited the increase in renal IL1beta mRNA expression and concentration.	peoniflorin	0-2	interleukin 1 beta	Mus musculus	50-57
26257642-9	2015	Mitochondria-derived ROS and cathepsin B, are also necessary for the microglial cell production of interleukin-1beta, a key inflammatory cytokine.	Reactive Oxygen Species	21-24	interleukin 1 beta	Mus musculus	99-116
26205049-3	2015	Furthermore, licorice extract inhibited the expression levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) in the livers of t-BHP-treated mice models.	tert-Butylhydroperoxide	140-145	interleukin 1 beta	Mus musculus	104-112
26185250-4	2015	Using a murine model of atherosclerosis, we found that cholesterol crystals acted both as priming and danger signals for IL-1beta production.	Cholesterol	55-66	interleukin 1 beta	Mus musculus	121-129
26078269-3	2015	In addition, the expression of IL-1beta and IRF4 is strongly reduced in the presence of sialostatin L.	sialostatin l	88-101	interleukin 1 beta	Mus musculus	31-39
26056255-4	2015	We compared the ability of Tr1 cells versus Foxp3(+) Tregs to suppress IL-1beta production from macrophages following LPS and ATP stimulation.	Adenosine Triphosphate	126-129	interleukin 1 beta	Mus musculus	71-79
26024895-5	2015	Even though inflammatory markers [IL-1beta and granulocyte colony-stimulating factor (G-CSF)] were decreased in IL-17A-deficient mice (IL-17A(-/-)) exposed to CS compared with wild-type (WT) mice, IL-17A(-/-) mice were per se not protected from CS-induced emphysematous disease.	Cesium	159-161	interleukin 1 beta	Mus musculus	34-42
26025058-8	2015	Prenatal exposure to FLX further suppressed TNFalpha and augmented IL-1beta secretion in adult males.	Fluoxetine	21-24	interleukin 1 beta	Mus musculus	67-75
26078269-5	2015	Furthermore, IRF4 binds to the promoters of Il1b and Il9, suggesting that sialostatin L suppresses mast cell-derived IL-9 preferentially by inhibiting IRF4.	sialostatin l	74-87	interleukin 1 beta	Mus musculus	44-48
26152605-10	2015	Furthermore, azithromycin specifically affected IL-1beta levels in a murine endotoxin sepsis model.	Azithromycin	13-25	interleukin 1 beta	Mus musculus	48-56
26152605-6	2015	Azithromycin, but not clarithromycin or roxithromycin, specifically inhibited IL-1alpha and IL-1beta secretion upon LPS stimulation.	Azithromycin	0-12	interleukin 1 beta	Mus musculus	92-100
26152605-11	2015	We provide the first evidence of a differential impact of macrolides on the inflammasome/IL-1beta axis, which may be of relevance in inflammasome-driven diseases such as chronic obstructive pulmonary disease or asthma.	Macrolides	58-68	interleukin 1 beta	Mus musculus	89-97
25930080-5	2015	In vivo depletion of Kupffer cells (KCs) by liposomal clodronate reduced liver injury and the expression of Il1b, but not Cxcl1, Cxcl2, and Cxcl5, suggesting that KCs are partly associated with liver injury, but not neutrophil recruitment, in a chronic-binge ethanol-feeding model.	Clodronic Acid	54-64	interleukin 1 beta	Mus musculus	108-112
26151119-6	2015	Further research demonstrated that procyanidin B2 decreased the expression of TNF-alpha, IL-1beta, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), as well as inhibited the translocation of nuclear factor-kappa B (NF-kappaB) p65 from the cytosol to the nuclear fraction in mouse liver.	procyanidin B2	35-49	interleukin 1 beta	Mus musculus	89-97
24854157-9	2015	In addition to these clinical data, studies in mice demonstrated that plasma IL-1beta, CX3CL1 and CXCL12 were also affected after acute and chronic cocaine administration, providing a preclinical model for further research.	Cocaine	148-155	interleukin 1 beta	Mus musculus	77-85
25585625-8	2015	We demonstrate that IL-1beta-treated GPR40(-/-) chondrocytes secret more inflammatory mediators (nitric oxide, interleukin-6, prostaglandin E2) and active catabolic enzymes (metalloproteinase-2, -9 [MMP-2, MMP-9]), and show decreased anabolism (glycoaminoglycan) compared to GPR40(+/+) cells.	Nitric Oxide	97-109	interleukin 1 beta	Mus musculus	20-28
25802070-8	2015	Moreover, DHCA effectively suppressed the palmitate-mediated activation of inflammasomes, which resulted in decreased production of IL-1beta.	dehydrodiconiferyl alcohol	10-14	interleukin 1 beta	Mus musculus	132-140
25802070-8	2015	Moreover, DHCA effectively suppressed the palmitate-mediated activation of inflammasomes, which resulted in decreased production of IL-1beta.	Palmitates	42-51	interleukin 1 beta	Mus musculus	132-140
25802070-9	2015	DHCA also showed therapeutic effects in the mouse DSS-induced colitis model by suppressing the production of TNF-alpha and IL-1beta and thus preventing weight loss and colon shrinkage.	dss	50-53	interleukin 1 beta	Mus musculus	123-131
25989356-6	2015	Mechanistically, peroxynitrite-induced TLR4 recruitment was linked to increased IL-1beta, sinusoidal injury, and Kupffer cell activation while blocking peroxynitrite-attenuated NASH symptoms.	Peroxynitrous Acid	17-30	interleukin 1 beta	Mus musculus	80-88
25585625-8	2015	We demonstrate that IL-1beta-treated GPR40(-/-) chondrocytes secret more inflammatory mediators (nitric oxide, interleukin-6, prostaglandin E2) and active catabolic enzymes (metalloproteinase-2, -9 [MMP-2, MMP-9]), and show decreased anabolism (glycoaminoglycan) compared to GPR40(+/+) cells.	Dinoprostone	126-142	interleukin 1 beta	Mus musculus	20-28
25585625-8	2015	We demonstrate that IL-1beta-treated GPR40(-/-) chondrocytes secret more inflammatory mediators (nitric oxide, interleukin-6, prostaglandin E2) and active catabolic enzymes (metalloproteinase-2, -9 [MMP-2, MMP-9]), and show decreased anabolism (glycoaminoglycan) compared to GPR40(+/+) cells.	glycoaminoglycan	245-261	interleukin 1 beta	Mus musculus	20-28
25914040-13	2015	Additionally, Wuling San decreased NLRP3 inflammasome activation and IL-1beta secretion in the kidney of fructose-fed mice.	Fructose	105-113	interleukin 1 beta	Mus musculus	69-77
25983199-0	2015	Fluorofenidone inhibits macrophage IL-1beta production by suppressing inflammasome activity.	5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone	0-14	interleukin 1 beta	Mus musculus	35-43
25535911-2	2015	Here, we report that resveratrol, a polyphenolic compound naturally produced by plants, inhibits NLRP3 inflammasome-derived IL-1beta secretion and pyroptosis in macrophages.	Resveratrol	21-32	interleukin 1 beta	Mus musculus	124-132
25907981-10	2015	Inflammatory mediators (CCR2, ICAM-1, IL-1beta, IL-6, IL-10, iNOS, MCP-1, and TNFalpha) after DSS treatment were significantly decreased in mice pretreated with piperine but corresponding conditions did not occur in mice with down-regulation of PXR by small interfering RNA (siRNA).	piperine	161-169	interleukin 1 beta	Mus musculus	38-46
25937482-6	2015	P2X7 antagonist A438079 suppressed NLRP3/ASC/caspase 1 activation, production of IL-1beta, IL-17A and IFN-gamma and neutrophil infiltration but not the production of IL-10, resulting in a significant amelioration of lung injury.	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine	16-23	interleukin 1 beta	Mus musculus	81-89
25914040-15	2015	The molecular mechanism of its action may be associated with the suppression of TLR4/MyD88 signaling and NLRP3 inflammasome activation to reduce IL-1beta production in high fructose-induced hyperuricemic mice.	Fructose	173-181	interleukin 1 beta	Mus musculus	145-153
25760811-5	2015	This was supported by screening of immune cytokine mRNAs, including interleukin (IL)-1beta and IL-6 from the skin of DNCB-treated mice.	Dinitrochlorobenzene	117-121	interleukin 1 beta	Mus musculus	68-90
25926522-4	2015	DSS treatment (2.5% in drinking water for 6 days) caused more severe colon inflammation, as evidenced by the presence of higher levels of myeloperoxidase and proinflammatory cytokines [tumor necrosis factor-alpha, interleukin (IL)-6, and IL-1beta], and greater weight loss, colonic tissue damage, and colon shortening, in IE-Cpr-null mice than in WT mice.	Dextran Sulfate	0-3	interleukin 1 beta	Mus musculus	238-246
25739325-10	2015	Increased production of nitric oxide, C-reactive proteins, and various pro-inflammatory cytokines (TNF-alpha, interleukin-1beta, and interleukin-6) in LPS-stimulated macrophages was significantly reduced by MZ treatment.	meso-zeaxanthin	207-209	interleukin 1 beta	Mus musculus	110-127
26040565-5	2015	Our results showed that linalool inhibited LPS-induced TNF-alpha, IL-1beta, NO, and PGE2 production in a dose-dependent manner.	linalool	24-32	interleukin 1 beta	Mus musculus	66-74
25737402-9	2015	Moreover, the administration of resveratrol significantly induced the activation of SIRT1 and the inhibition of HIF-2alpha expression in mouse OA cartilage and in IL-1beta-treated human chondrocytes.	Resveratrol	32-43	interleukin 1 beta	Mus musculus	163-171
25913072-2	2015	alpha-Chaconine inhibited the expressions of cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) at the transcriptional level, and attenuated the transcriptional activity of activator protein-1 (AP-1) by reducing the translocation and phosphorylation of c-Jun.	alpha-chaconine	0-15	interleukin 1 beta	Mus musculus	71-88
26132856-8	2015	Oxysophocarpine significantly suppressed over-expression of cyclooxygenase-2, tumor necrosis factor alpha, interleukin-1 beta, interleukin-6 and prostaglandin E2, and inhibited the over-phosphorylation of extracellular signal-regulated kinase 1/2.	oxysophocarpine	0-15	interleukin 1 beta	Mus musculus	107-125
26132856-9	2015	Based on these findings we propose that oxysophocarpine attenuates inflammatory pain by suppressing the levels of phosphorylation of extracellular signal-regulated kinase 1/2, cyclooxygenase-2, prostaglandin E2, tumor necrosis factor alpha, interleukin-1 beta and interleukin-6.	oxysophocarpine	40-55	interleukin 1 beta	Mus musculus	241-259
25362520-6	2015	RESULTS: In the NaHS(-) group, severe IRI was apparent by the ALT leakage, tissue injury score, apoptosis, lipid peroxidation, and inflammation (higher plasma TNF-alpha, IL-6, IL-1beta, IFN-gamma, IL-23, IL-17, and CD40L), whereas IRI was significantly ameliorated in the NaHS(+) group.	sodium bisulfide	16-20	interleukin 1 beta	Mus musculus	176-184
26122092-8	2015	In addition, sakuranetin treatment decreased the inflammation and the levels of TNF-alpha, IL-1beta and M-CSF in the BALF as well as the levels of NF-kappaB and 8-iso-PGF-2alpha in the lungs of the elastase-treated animals.	sakuranetin	13-24	interleukin 1 beta	Mus musculus	91-99
25913072-2	2015	alpha-Chaconine inhibited the expressions of cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) at the transcriptional level, and attenuated the transcriptional activity of activator protein-1 (AP-1) by reducing the translocation and phosphorylation of c-Jun.	alpha-chaconine	0-15	interleukin 1 beta	Mus musculus	90-98
26091108-8	2015	RESULTS: Priming of THP-1 macrophages with LPS increased pro-IL-1beta and subsequent exposure to MWCNTs induced IL-1beta secretion.	mwcnts	97-103	interleukin 1 beta	Mus musculus	112-120
25839117-15	2015	The CE, the EtOAc and AF fractions, and the DCQs also decreased IL-1beta levels (P &lt; 0.01).	4,5-dicaffeoyl quinic acid	44-48	interleukin 1 beta	Mus musculus	64-72
26091108-13	2015	MWCNT exposure after HDM sensitization increased total cell numbers in BALF, but decreased numbers of neutrophils and IL-1beta in BALF as well as reduced pro-caspase-1 in lung tissue.	mwcnt	0-5	interleukin 1 beta	Mus musculus	118-126
26091108-15	2015	CONCLUSIONS: These data indicate that Th2 cytokines suppress MWCNT-induced inflammasome activation via STAT6-dependent down-regulation of pro-caspase-1 and suggest that suppression of inflammasome activation and IL-1beta by an allergic lung microenvironment is a mechanism through which MWCNTs exacerbate allergen-induced airway fibrosis.	mwcnt	61-66	interleukin 1 beta	Mus musculus	212-220
26091541-6	2015	Microglia were able to produce IL-1beta in response to different classical inflammasome activators, such as ATP, Nigericin or Alum.	Adenosine Triphosphate	108-111	interleukin 1 beta	Mus musculus	31-39
26091541-6	2015	Microglia were able to produce IL-1beta in response to different classical inflammasome activators, such as ATP, Nigericin or Alum.	Nigericin	113-122	interleukin 1 beta	Mus musculus	31-39
26091541-6	2015	Microglia were able to produce IL-1beta in response to different classical inflammasome activators, such as ATP, Nigericin or Alum.	aluminum sulfate	126-130	interleukin 1 beta	Mus musculus	31-39
26059659-6	2015	Ibrutinib inhibits maturation of IL-1beta by suppressing caspase-1 activation in infiltrating macrophages and neutrophils in the infarcted area of ischaemic brain.	ibrutinib	0-9	interleukin 1 beta	Mus musculus	33-41
25929180-8	2015	Ziram also inhibited IL-1beta production by macrophages in response to lipopolysaccharide and bacterial clearance during Salmonella infection of macrophage cells.	Ziram	0-5	interleukin 1 beta	Mus musculus	21-29
25914377-2	2015	Monosodium urate monohydrate (MSU) crystals cause gout by activating the NLRP3 inflammasome, leading to interleukin-1beta (IL-1beta) production and neutrophil recruitment.	Uric Acid	0-28	interleukin 1 beta	Mus musculus	104-121
26047341-6	2015	In the present study, we showed that methionine supplementation induced mild HHcy in mice, associated with the elevations of TNF-alpha and IL-1beta in the plasma and reductions of plasma H2S level and CSE expression in the peritoneal macrophages.	Methionine	37-47	interleukin 1 beta	Mus musculus	139-147
26047341-7	2015	H2S-releasing compound GYY4137 attenuated the increases of TNF-alpha and IL-1beta in the plasma of HHcy mice and Hcy-treated raw264.7 cells while CSE inhibitor PAG exacerbated it.	Hydrogen Sulfide	0-3	interleukin 1 beta	Mus musculus	73-81
26047341-7	2015	H2S-releasing compound GYY4137 attenuated the increases of TNF-alpha and IL-1beta in the plasma of HHcy mice and Hcy-treated raw264.7 cells while CSE inhibitor PAG exacerbated it.	GYY 4137	23-30	interleukin 1 beta	Mus musculus	73-81
26047341-7	2015	H2S-releasing compound GYY4137 attenuated the increases of TNF-alpha and IL-1beta in the plasma of HHcy mice and Hcy-treated raw264.7 cells while CSE inhibitor PAG exacerbated it.	Homocysteine	100-103	interleukin 1 beta	Mus musculus	73-81
25577335-9	2015	treatment significantly reduced histopathological severity; suppressed expression of COX-2, TNF-alpha, and interleukin-1beta in TNBS-induced mice.	Trinitrobenzenesulfonic Acid	128-132	interleukin 1 beta	Mus musculus	107-124
26023864-3	2015	Both BF3-1 and mixture of these cyanidins at the same ratio reduced lipopolysaccharide (LPS)-induced protein level of iNOS expression and suppressed mRNA and protein expressions of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta through inhibiting the phosphorylation of mitogen-activated protein kinases (MAPKs) and STAT3 in murine macrophage RAW264.7 cells.	cyanidin	32-41	interleukin 1 beta	Mus musculus	240-248
25914377-13	2015	CONCLUSION: In the absence of microbiota, there is decreased production of short-chain fatty acids that are necessary for adequate inflammasome assembly and IL-1beta production in a manner that is at least partially dependent on GPR43.	Fatty Acids, Volatile	75-98	interleukin 1 beta	Mus musculus	157-165
25914377-2	2015	Monosodium urate monohydrate (MSU) crystals cause gout by activating the NLRP3 inflammasome, leading to interleukin-1beta (IL-1beta) production and neutrophil recruitment.	Uric Acid	0-28	interleukin 1 beta	Mus musculus	123-131
25914377-2	2015	Monosodium urate monohydrate (MSU) crystals cause gout by activating the NLRP3 inflammasome, leading to interleukin-1beta (IL-1beta) production and neutrophil recruitment.	Uric Acid	30-33	interleukin 1 beta	Mus musculus	104-121
25914377-2	2015	Monosodium urate monohydrate (MSU) crystals cause gout by activating the NLRP3 inflammasome, leading to interleukin-1beta (IL-1beta) production and neutrophil recruitment.	Uric Acid	30-33	interleukin 1 beta	Mus musculus	123-131
25907044-8	2015	Furthermore, it is shown that the level of both IL-1beta and IL-6 is correlated with the composition of biominerals, in particular the ratio of Mg(Sr) to Ca, and the pH sensitivity of biominerals.	Magnesium	144-146	interleukin 1 beta	Mus musculus	48-56
25907044-8	2015	Furthermore, it is shown that the level of both IL-1beta and IL-6 is correlated with the composition of biominerals, in particular the ratio of Mg(Sr) to Ca, and the pH sensitivity of biominerals.	Strontium	147-149	interleukin 1 beta	Mus musculus	48-56
25831201-9	2015	In the model group, Glu and GABA levels decreased (P&lt;0.05), and Glu/GABA, TNF-alpha, and IL-1beta increased (P&lt;0.01) with puerarin treatment, returning to near normal levels.	puerarin	128-136	interleukin 1 beta	Mus musculus	92-100
25651822-8	2015	Similarly, treatment with YM-58483 after the onset of CIA: (i) reversed the clinical scores; (ii) reduced paw oedema; (iii) attenuated mechanical and thermal hypersensitivity; (iv) improved spontaneous motor activity; (v) decreased periphery production of IL-1beta, IL-6 and TNF-alpha; and (vi) reduced spinal activation of ERK and calmodulin-dependent PKII (CaMKIIalpha).	4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide	26-34	interleukin 1 beta	Mus musculus	256-264
25626736-0	2015	Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1beta secretion and insulin resistance despite obesity.	Fatty Acids, Monounsaturated	0-26	interleukin 1 beta	Mus musculus	94-102
26077892-5	2015	ETT (1.0 g/kg po) reduced the level of malondialdehyde in the edemic paw by increasing the activity of antioxidant enzymes, e.g., superoxide dismutase and glutathione reductase, in the liver and reducing TNF-alpha, IL-1beta, and IL-6 activity in the edemic paw.	ett	0-3	interleukin 1 beta	Mus musculus	215-223
25739980-9	2015	Furthermore, quercetin treatment downregulated cytoplasmic HMGB1, RAGE, nuclear p-NFkappaB, p-ERK1/2, COX2, TNFalpha, IL-1beta, IL-2Ralpha, IFNgamma and IL-4 and upregulated nuclear Nrf2.	Quercetin	13-22	interleukin 1 beta	Mus musculus	118-126
25580516-9	2015	Inhibitor experiments indicated that O157:H7-induced IL-1beta production was largely dependent upon caspase-1 activation and partially dependent upon ATP signalling and cathepsin B release, which were both involved in NLRP3 activation.	Adenosine Triphosphate	150-153	interleukin 1 beta	Mus musculus	53-61
25847097-9	2015	Small mRNA level increases of CD11b, glial fibrillary acidic protein (GFAP), and IL-1beta were found in the pilocarpine model, consistent with IL-1beta contributing to spontaneous seizures, whereas mRNA levels of TNFalpha and Ym1 were decreased.	Pilocarpine	108-119	interleukin 1 beta	Mus musculus	81-89
25847097-9	2015	Small mRNA level increases of CD11b, glial fibrillary acidic protein (GFAP), and IL-1beta were found in the pilocarpine model, consistent with IL-1beta contributing to spontaneous seizures, whereas mRNA levels of TNFalpha and Ym1 were decreased.	Pilocarpine	108-119	interleukin 1 beta	Mus musculus	143-151
25626736-1	2015	Saturated fatty acid (SFA) high-fat diets (HFDs) enhance interleukin (IL)-1beta-mediated adipose inflammation and insulin resistance.	Fatty Acids	0-20	interleukin 1 beta	Mus musculus	57-79
25626736-2	2015	However, the mechanisms by which different fatty acids regulate IL-1beta and the subsequent effects on adipose tissue biology and insulin sensitivity in vivo remain elusive.	Fatty Acids	43-54	interleukin 1 beta	Mus musculus	64-72
25626736-3	2015	We hypothesized that the replacement of SFA for monounsaturated fatty acid (MUFA) in HFDs would reduce pro-IL-1beta priming in adipose tissue and attenuate insulin resistance via MUFA-driven AMPK activation.	Fatty Acids	40-43	interleukin 1 beta	Mus musculus	107-115
25870195-6	2015	Furthermore, compared with wild-type mice, ghrelin knockout mice showed suppression of the cholinergic anti-inflammatory pathway, as indicated by reduced parasympathetic nerve activity and higher plasma interleukin-1beta and interleukin-6 levels.	Ghrelin	43-50	interleukin 1 beta	Mus musculus	203-220
25626736-3	2015	We hypothesized that the replacement of SFA for monounsaturated fatty acid (MUFA) in HFDs would reduce pro-IL-1beta priming in adipose tissue and attenuate insulin resistance via MUFA-driven AMPK activation.	Fatty Acids, Monounsaturated	48-74	interleukin 1 beta	Mus musculus	107-115
25626736-3	2015	We hypothesized that the replacement of SFA for monounsaturated fatty acid (MUFA) in HFDs would reduce pro-IL-1beta priming in adipose tissue and attenuate insulin resistance via MUFA-driven AMPK activation.	Fatty Acids, Monounsaturated	76-80	interleukin 1 beta	Mus musculus	107-115
25626736-6	2015	In vitro, we demonstrated that the MUFA oleic acid can impede ATP-induced IL-1beta secretion from lipopolysaccharide- and SFA-primed cells in an AMPK-dependent manner.	Fatty Acids, Monounsaturated	35-39	interleukin 1 beta	Mus musculus	74-82
25626736-6	2015	In vitro, we demonstrated that the MUFA oleic acid can impede ATP-induced IL-1beta secretion from lipopolysaccharide- and SFA-primed cells in an AMPK-dependent manner.	Oleic Acid	40-50	interleukin 1 beta	Mus musculus	74-82
25626736-6	2015	In vitro, we demonstrated that the MUFA oleic acid can impede ATP-induced IL-1beta secretion from lipopolysaccharide- and SFA-primed cells in an AMPK-dependent manner.	Adenosine Triphosphate	62-65	interleukin 1 beta	Mus musculus	74-82
25981879-6	2015	Meanwhile, the mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, and monocyte chemotactic protein in baicalein-treated groups was markedly reduced compared with the vehicle-treated group.	baicalein	149-158	interleukin 1 beta	Mus musculus	94-111
25582105-0	2015	Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1beta in mice.	Alcohols	28-35	interleukin 1 beta	Mus musculus	68-85
25582105-1	2015	BACKGROUND &amp; AIMS: It was reported that alcohol consumption activated the NLRP3 inflammasome in Kupffer cells, leading to mature interleukin (IL)-1beta release in alcoholic liver injury; however, how IL-1beta promotes liver injury remains unclear.	Alcohols	44-51	interleukin 1 beta	Mus musculus	133-155
25582105-1	2015	BACKGROUND &amp; AIMS: It was reported that alcohol consumption activated the NLRP3 inflammasome in Kupffer cells, leading to mature interleukin (IL)-1beta release in alcoholic liver injury; however, how IL-1beta promotes liver injury remains unclear.	Alcohols	44-51	interleukin 1 beta	Mus musculus	204-212
25582105-4	2015	Kupffer cells and IL-1beta were required for the hepatic iNKT accumulation, as either blocking IL-1beta signaling with a recombinant IL-1 receptor antagonist (IL-1Ra), depleting Kupffer cells by clodronate liposomes, or specifically silencing IL-1beta in Kupffer cells by nanoparticle-encapsulated siRNA, resulted in inhibited hepatic iNKT cell accumulation and activation, as well as amelioration of alcoholic fatty liver.	Clodronic Acid	195-205	interleukin 1 beta	Mus musculus	18-26
25582105-6	2015	Increased gene and protein expression of mature IL-1beta correlated with elevated expression of the NLRP3 inflammasome components NLRP3, ASC, and cleaved caspase-1 in Kupffer cells from ethanol-exposed wild-type mice.	Ethanol	186-193	interleukin 1 beta	Mus musculus	48-56
25582105-8	2015	CONCLUSIONS: After alcohol-exposure Kupffer cell-derived IL-1beta triggered by NLRP3 activation, recruits and activates hepatic iNKT cells, subsequently promoting liver inflammation and neutrophil infiltration, and inducing alcoholic liver injury.	Alcohols	19-26	interleukin 1 beta	Mus musculus	57-65
25919915-3	2015	HDMPPA also attenuated the LPS-induced expression and secretion of proinflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-1beta.	3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid	0-6	interleukin 1 beta	Mus musculus	134-151
25907238-4	2015	The results showed that D(-)-Salicin markedly decreased TNF-alpha, IL-1beta and IL-6 concentrations and increased IL-10 concentration.	salicin	24-36	interleukin 1 beta	Mus musculus	67-75
25887886-0	2015	Blocking IL1beta Pathway Following Paclitaxel Chemotherapy Slightly Inhibits Primary Tumor Growth but Promotes Spontaneous Metastasis.	Paclitaxel	35-45	interleukin 1 beta	Mus musculus	9-16
26012743-0	2015	TC-2559, an alpha4beta2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1beta through STAT3 inhibition in cultured murine macrophages.	TC 2559	0-7	interleukin 1 beta	Mus musculus	104-112
26012743-2	2015	TC-2559 suppressed the upregulation of CC-chemokine ligand 3 (CCL3) and interleukin-1beta (IL-1beta) following lipopolysaccharide (LPS) treatment in J774A.1 cells.	TC 2559	0-7	interleukin 1 beta	Mus musculus	72-89
26012743-2	2015	TC-2559 suppressed the upregulation of CC-chemokine ligand 3 (CCL3) and interleukin-1beta (IL-1beta) following lipopolysaccharide (LPS) treatment in J774A.1 cells.	TC 2559	0-7	interleukin 1 beta	Mus musculus	91-99
26012743-4	2015	Blockade of pSTAT3 by AG490 inhibited the upregulation of CCL3 and IL-1beta after LPS.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	22-27	interleukin 1 beta	Mus musculus	67-75
26012743-5	2015	In conclusion, TC-2559-driven alpha4beta2 nAChR signaling suppressed the upregulation of CCL3 and IL-1beta by inhibiting pSTAT3 in inflammatory macrophages, resulting in the suppression of neuropathic pain.	TC 2559	15-22	interleukin 1 beta	Mus musculus	98-106
25887886-2	2015	Here, we show that the proinflammatory cytokine IL1beta is overexpressed in response to paclitaxel chemotherapy in macrophages, subsequently promoting the invasive properties of malignant cells.	Paclitaxel	88-98	interleukin 1 beta	Mus musculus	48-55
25887886-4	2015	Tumors from mice treated with combined therapy of paclitaxel and the IL1 receptor antagonist anakinra exhibit increased number of M2 macrophages and vessel leakiness when compared with paclitaxel monotherapy-treated mice, indicating a prometastatic role of M2 macrophages in the IL1beta-deprived microenvironment.	Paclitaxel	50-60	interleukin 1 beta	Mus musculus	279-286
25558818-6	2015	Moreover, gamma-EC and gamma-EV reduced the expression of TNF-alpha, IL-6, INF-gamma, IL-1beta, and IL-17, and increased the expression of IL-10 in the colon, in a CaSR-dependent manner.	gamma-ec	10-18	interleukin 1 beta	Mus musculus	86-94
25818525-7	2015	RESULTS: The results showed that fucosterol attenuated lung histopathologic changes, wet-to-dry ratio, and tumor necrosis factor-alpha, interleukin (IL)-6 and IL-1beta production in LPS-induced ALI in mice.	fucosterol	33-43	interleukin 1 beta	Mus musculus	159-167
25818525-8	2015	Meanwhile, fucosterol inhibited NF-kappaB activation and tumor necrosis factor-alpha, IL-6, and IL-1beta production in LPS-stimulated alveolar macrophages.	fucosterol	11-21	interleukin 1 beta	Mus musculus	96-104
25955525-4	2015	EGCG attenuated BDL-induced gene expression of pro-fibrotic markers (Collagen, Fibronectin, alpha 2 smooth muscle actin or SMA and connective tissue growth factor or CTGF), mitochondrial oxidative stress, cell death marker (DNA fragmentation and PARP activity), NFkappaB activity and pro-inflammatory cytokines (TNFalpha, MIP1alpha, IL1beta, and MIP2).	epigallocatechin gallate	0-4	interleukin 1 beta	Mus musculus	333-340
25800110-10	2015	Apigenin or fluoxetine also effectively attenuated LPS-induced production of pro-inflammatory cytokines IL-1beta (interleukin-1beta) and TNF-alpha (tumor necrosis factor-alpha).	Apigenin	0-8	interleukin 1 beta	Mus musculus	104-112
25800110-10	2015	Apigenin or fluoxetine also effectively attenuated LPS-induced production of pro-inflammatory cytokines IL-1beta (interleukin-1beta) and TNF-alpha (tumor necrosis factor-alpha).	Apigenin	0-8	interleukin 1 beta	Mus musculus	114-131
25800110-10	2015	Apigenin or fluoxetine also effectively attenuated LPS-induced production of pro-inflammatory cytokines IL-1beta (interleukin-1beta) and TNF-alpha (tumor necrosis factor-alpha).	Fluoxetine	12-22	interleukin 1 beta	Mus musculus	104-112
25800110-10	2015	Apigenin or fluoxetine also effectively attenuated LPS-induced production of pro-inflammatory cytokines IL-1beta (interleukin-1beta) and TNF-alpha (tumor necrosis factor-alpha).	Fluoxetine	12-22	interleukin 1 beta	Mus musculus	114-131
25859982-7	2015	Moreover, elevated TNF-alpha and IL-1beta levels, a result of EAE, were decreased in serum and neurological deficits as clinical signs were reversed with HP treatment in EAE mice, given HP.	Hesperidin	154-156	interleukin 1 beta	Mus musculus	33-41
25859982-7	2015	Moreover, elevated TNF-alpha and IL-1beta levels, a result of EAE, were decreased in serum and neurological deficits as clinical signs were reversed with HP treatment in EAE mice, given HP.	Hesperidin	186-188	interleukin 1 beta	Mus musculus	33-41
25429101-8	2015	PFCE-O2-treated HbSS mice also had significantly lower pulmonary leukocyte counts, lower interleukin 1beta and interferon gamma levels, and higher interleukin 10 levels than PFCE-air-treated HbSS mice.	Oxygen	5-7	interleukin 1 beta	Mus musculus	89-106
25987769-12	2015	DHM could significantly decrease serum ALT, AST, IL-1beta, IL-6 and TNF-alpha and increase serum albumin, SOD and liver SOD compared to the control group after CCl4 treatment (P &lt; 0.05).	dihydromyricetin	0-3	interleukin 1 beta	Mus musculus	49-57
25558818-6	2015	Moreover, gamma-EC and gamma-EV reduced the expression of TNF-alpha, IL-6, INF-gamma, IL-1beta, and IL-17, and increased the expression of IL-10 in the colon, in a CaSR-dependent manner.	gamma-ev	23-31	interleukin 1 beta	Mus musculus	86-94
25739561-17	2015	Curcumin blocked lipopolysaccharide-upregulated expression of tumour necrosis factor-alpha, IL-1beta, and IL-6.	Curcumin	0-8	interleukin 1 beta	Mus musculus	92-100
25701613-10	2015	Following ex vivo LPS stimulation, microglia from mice exposed to RSD, had higher mRNA expression of IL-6, TNF-alpha, and IL-1beta, and this was reversed by imipramine treatment.	Imipramine	157-167	interleukin 1 beta	Mus musculus	122-130
25637482-4	2015	We found a strong immune response in the gut of mice treated with MPTP, as demonstrated by the prominent presence of macrophages derived from CD115(+) CD11b(+) Ly6C(Hi) monocytes, known as M1 monocytes, and increased production of IL-1beta and IL-6.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	66-70	interleukin 1 beta	Mus musculus	231-239
25958838-4	2015	Inhalation of BCQB suppressed the accumulation of neutrophils and macrophages in airways and lung and also inhibited the CS-induced increases in mRNA levels of keratinocyte-derived chemokine, monocyte chemotactic protein-1, tumor necrosis factor-alpha, and interleukin-1beta in lung and protein expression levels in bronchoalveolar lavage fluid.	bencycloquidium bromide	14-18	interleukin 1 beta	Mus musculus	257-274
25492506-10	2015	Notably, inhibition of HDAC abolished taurocholate-induced gene expression of cyclooxygenase-2, MIP-2, monocyte chemotactic protein-1, IL-6, and IL-1beta in the pancreas.	Taurocholic Acid	38-50	interleukin 1 beta	Mus musculus	145-153
25958838-4	2015	Inhalation of BCQB suppressed the accumulation of neutrophils and macrophages in airways and lung and also inhibited the CS-induced increases in mRNA levels of keratinocyte-derived chemokine, monocyte chemotactic protein-1, tumor necrosis factor-alpha, and interleukin-1beta in lung and protein expression levels in bronchoalveolar lavage fluid.	Cesium	121-123	interleukin 1 beta	Mus musculus	257-274
25819229-6	2015	The expression of IL-17 and other proinflammatory cytokines, including IL-1beta, IL-6, TNF-alpha and IL-21, were markedly reduced in the arthritic joints of digoxin-treated CIA mice.	Digoxin	157-164	interleukin 1 beta	Mus musculus	71-79
25609426-10	2015	Exercise reduced 25, 75, and 50% of the IL-1beta plus IFN-gamma-induced iNOS, nitrite, and cleaved caspase-3 content, respectively, in pancreatic islets.	Nitrites	78-85	interleukin 1 beta	Mus musculus	40-48
25740962-4	2015	Chronic alcohol feeding in C57Bl/6 mice led to increased expression of M1 (TNF-alpha, MCP1, and IL-1beta) and M2 (Arg1, Mrc1, and IL-10) genes and the frequency of CD206+CD163+ M2 macrophages in the liver.	Alcohols	8-15	interleukin 1 beta	Mus musculus	96-104
25805308-3	2015	The effects of thymoquinone on inflammatory mediators TNF-alpha, IL-1beta, NO and PGE2 production were detected by ELISA.	thymoquinone	15-27	interleukin 1 beta	Mus musculus	65-73
25805308-5	2015	Our results showed that thymoquinone dose-dependently inhibited LPS-induced TNF-alpha, IL-1beta, NO and PGE2 production.	thymoquinone	24-36	interleukin 1 beta	Mus musculus	87-95
24996526-5	2015	IL-1beta-induced bone resorption was associated with elevated serum FGF23 levels, an effect abolished by pre-treatment with pamidronate.	Pamidronate	124-135	interleukin 1 beta	Mus musculus	0-8
25311527-8	2015	Furthermore, mice treated with high-dose liquiritigenin experienced significantly suppressed tumor necrosis factor-alpha, IL-1beta, and IL-6 as well as enhanced IL-10 expression (all P &lt; 0.05).	liquiritigenin	41-55	interleukin 1 beta	Mus musculus	122-130
25005005-5	2015	The results showed that punicalagin treatment attenuated LPS-induced lung edema, elevating TNF-alpha, IL-6, and IL-1beta levels in the bronchoalveolar lavage fluid (BALF).	punicalagin	24-35	interleukin 1 beta	Mus musculus	112-120
25867480-5	2015	Emodin treatment attenuated interleukin (IL)-1beta secretion via the inhibition of NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation induced by ATP, nigericin, and silica crystals.	Silicon Dioxide	198-204	interleukin 1 beta	Mus musculus	28-50
25662507-7	2015	We found that donepezil could inhibit the expression of CD68, a specific marker of microglial activation, and reduce the release of proinflammatory cytokines including tumor necrosis factor-alpha and interleukin-1beta.	Donepezil	14-23	interleukin 1 beta	Mus musculus	200-217
25512114-8	2015	TDZD-8 inhibited the activation of GSK-3beta and caspase 1, with a concomitant decrease in interleukin-1beta (IL-1beta) synthesis.	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	0-6	interleukin 1 beta	Mus musculus	91-108
25512114-8	2015	TDZD-8 inhibited the activation of GSK-3beta and caspase 1, with a concomitant decrease in interleukin-1beta (IL-1beta) synthesis.	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	0-6	interleukin 1 beta	Mus musculus	110-118
25514628-10	2015	On the other hand, STZ-induced diabetic mice presented significant increases in pulmonary neutrophil infiltration, pro-inflammatory cytokines (IL-1beta and IL-6) production, as well as TLR4 expression.	Streptozocin	19-22	interleukin 1 beta	Mus musculus	143-151
24950782-9	2015	Cisplatin increased the renal production of the proinflammatory cytokines tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and transforming growth factor (TGF)-beta1.	Cisplatin	0-9	interleukin 1 beta	Mus musculus	109-131
25097077-7	2015	Hyperoside also reduced the CLP-induced release of HMGB1, the production of interleukin (IL)-1beta, and septic mortality.	hyperoside	0-10	interleukin 1 beta	Mus musculus	76-98
25940281-7	2015	Sophoridine suppressed the expressions of TLR4 mRNA, c-Jun mRNA and protein, and reduced the secretion of TNF-alpha and IL-1beta in LPS-stimulated RAW264.7 cells in sophoridine intervention group.	matrine	0-11	interleukin 1 beta	Mus musculus	120-128
25940281-7	2015	Sophoridine suppressed the expressions of TLR4 mRNA, c-Jun mRNA and protein, and reduced the secretion of TNF-alpha and IL-1beta in LPS-stimulated RAW264.7 cells in sophoridine intervention group.	matrine	165-176	interleukin 1 beta	Mus musculus	120-128
25940281-8	2015	CONCLUSION: Sophoridine down-regulated the secretion of TNF-alpha and IL-1beta in LPS-induced RAW264.7 cells via inhibiting the expressions of TLR4 and c-Jun.	matrine	12-23	interleukin 1 beta	Mus musculus	70-78
25927611-6	2015	PegHYAL also reduced the levels of transforming growth factor (TGF)-beta, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha in the serum and lungs, while spiperone reduced the level of the serum IL-1beta.	peghyal	0-7	interleukin 1 beta	Mus musculus	74-96
25927611-6	2015	PegHYAL also reduced the levels of transforming growth factor (TGF)-beta, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha in the serum and lungs, while spiperone reduced the level of the serum IL-1beta.	peghyal	0-7	interleukin 1 beta	Mus musculus	203-211
25900651-7	2015	Intravaginal administration of wild-type (WT) mice with glyburide, a potent inhibitor of the NLRP3 inflammasome, reduced PMN infiltration and IL-1beta to levels comparable to those observed in Nlrp3(-/-) mice.	Glyburide	56-65	interleukin 1 beta	Mus musculus	142-150
25875356-7	2015	Cisplatin induced kidney specific mitochondrial oxidative stress, impaired activities of mitochondrial electron transport chain enzyme complexes, impaired anti-oxidant defense enzyme activities such as glutathione peroxidase (GPX) and manganese superoxide dismutase (MnSOD) in mitochondria, inflammation (tumor necrosis factor alpha and interleukin 1beta), increased accumulation of NF-kappaB in nuclear fraction, p53 induction, and apoptotic cell death (caspase 3 activity and DNA fragmentation).	Cisplatin	0-9	interleukin 1 beta	Mus musculus	337-354
25867480-5	2015	Emodin treatment attenuated interleukin (IL)-1beta secretion via the inhibition of NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation induced by ATP, nigericin, and silica crystals.	Adenosine Triphosphate	178-181	interleukin 1 beta	Mus musculus	28-50
25867480-5	2015	Emodin treatment attenuated interleukin (IL)-1beta secretion via the inhibition of NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation induced by ATP, nigericin, and silica crystals.	Nigericin	183-192	interleukin 1 beta	Mus musculus	28-50
25687021-7	2015	However, RSV decreased these levels in the case of IL-1beta and TNF-alpha but only in old mice showing no effect on young and mature animals.	Resveratrol	9-12	interleukin 1 beta	Mus musculus	51-59
25028260-7	2015	The expression of IL-1beta, IL-6, and GFAP was increased in Pb-exposed groups in comparison with the control group (p &lt; 0.05).	Lead	60-62	interleukin 1 beta	Mus musculus	18-26
25028260-8	2015	The high expression of IL-1beta, IL-6, and GFAP in the hippocampus of pups may contribute to the neurotoxicity associated with maternal Pb exposure.	Lead	136-138	interleukin 1 beta	Mus musculus	23-31
25059213-7	2015	In addition, AD, DBP, or FTH inhibited the mRNA expression of tumor necrosis factor alpha or interleukin-1 beta.	Fenitrothion	25-28	interleukin 1 beta	Mus musculus	93-111
25117568-10	2015	In addition, silymarin pretreatment dampened the secretion of TNF-alpha, IL-1beta, and IL-8 in BALF.	Silymarin	13-22	interleukin 1 beta	Mus musculus	73-81
25698557-6	2015	Oral administration of AIII and sarsasapogenin inhibited 2,3,4-trinitrobenzene sulfonic acid (TNBS)-induced colon shortening and myeloperoxidase activity in mice, along with reducing NF-kappaB activation and interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6 levels, while simultaneously increasing IL-10.	sarsasapogenin	32-46	interleukin 1 beta	Mus musculus	208-230
25698557-6	2015	Oral administration of AIII and sarsasapogenin inhibited 2,3,4-trinitrobenzene sulfonic acid (TNBS)-induced colon shortening and myeloperoxidase activity in mice, along with reducing NF-kappaB activation and interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6 levels, while simultaneously increasing IL-10.	Trinitrobenzenesulfonic Acid	94-98	interleukin 1 beta	Mus musculus	208-230
25616502-15	2015	In the pleurisy model, induced by carrageenan, treatment with SA inhibited important events involved in inflammatory responses, namely leukocyte influx, plasma leakage, and increased inflammatory mediators (TNF-alpha, IL-1beta, and chemokine CXCL1), in the pleural exudate.	2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine	62-64	interleukin 1 beta	Mus musculus	218-226
25294243-10	2015	Furthermore, inhibition of COX-2 in mice in vivo with celecoxib reduced serum levels of IL-1beta and caspase-1 activity in the spleen and liver in response to lipopolysaccharide (LPS) challenge.	Celecoxib	54-63	interleukin 1 beta	Mus musculus	88-96
25406893-5	2015	Mice subjected to isoflurane with laparotomy, compared with mice receiving isoflurane alone, had &gt;2-fold upregulation of genes in inflammation (Osm, IL1rn, IL1b, and Csf1), oxidative stress (Hmox1), heat shock (Hspa1b), growth arrest (Cdkn1a), and DNA repair (Ugt1a2).	Isoflurane	18-28	interleukin 1 beta	Mus musculus	159-163
25406893-5	2015	Mice subjected to isoflurane with laparotomy, compared with mice receiving isoflurane alone, had &gt;2-fold upregulation of genes in inflammation (Osm, IL1rn, IL1b, and Csf1), oxidative stress (Hmox1), heat shock (Hspa1b), growth arrest (Cdkn1a), and DNA repair (Ugt1a2).	Isoflurane	75-85	interleukin 1 beta	Mus musculus	159-163
25711428-7	2015	Moreover, in in vivo experiments, NCX 429, at the lowest dose tested, was able to significantly inhibit cell influx in response to IL-1beta administration although naproxen was found to be more potent than NCX 429 at reducing PGE2 in inflammatory exudates.	Naproxen	164-172	interleukin 1 beta	Mus musculus	131-139
25711428-7	2015	Moreover, in in vivo experiments, NCX 429, at the lowest dose tested, was able to significantly inhibit cell influx in response to IL-1beta administration although naproxen was found to be more potent than NCX 429 at reducing PGE2 in inflammatory exudates.	Dinoprostone	226-230	interleukin 1 beta	Mus musculus	131-139
25613820-3	2015	It inhibited, in a concentration-dependent manner, interleukin (IL)-1beta and IL-18, but not IL-6 and IL-12, production in lipopolysaccharide and cholesterol crystal-activated cultured mouse peritoneal macrophages, with a maximum effect at  50 nmol/L and EC50 values for both cytokines of   10 nmol/L.	Cholesterol	146-157	interleukin 1 beta	Mus musculus	51-73
25822523-10	2015	Both peripherally and in the spinal cord, vinpocetine also inhibited: antioxidant capacity and GSH depletion; increased superoxide anion; IL-1beta and TNF-alpha levels; and NF-kappaB activation.	vinpocetine	42-53	interleukin 1 beta	Mus musculus	138-146
25730469-5	2015	ACAP also showed significant inhibitory activities on IL-1beta, IL-6, and COX-2 gene expressions in cultured RAW 264.7 mouse macrophage cells.	acap	0-4	interleukin 1 beta	Mus musculus	54-62
25631463-6	2015	Moreover, 6-gingerol significantly suppressed the circulating concentrations of interleukin-1beta and tumor necrosis factor alpha and restored the colonic nitric oxide concentration and myeloperoxidase activity to normal in DSS-treated mice.	gingerol	10-20	interleukin 1 beta	Mus musculus	80-129
25646681-7	2015	Oropharyngeal aspiration in mice confirmed that AP-Hipco tubes, graphene (BSA-dispersed), GO-S and GO-L could induce IL-1beta and TGF-beta1 production in the lung in parallel with lung fibrosis.	Graphite	64-72	interleukin 1 beta	Mus musculus	117-125
25613820-6	2015	Intraperitoneal injection of arglabin (2.5 ng/g body weight twice daily for 13 weeks) into female ApoE2.Ki mice fed a high-fat diet resulted in a decreased IL-1beta plasma level compared with vehicle-treated mice (5.2+-1.0 versus 11.7+-1.1 pg/mL).	arglabin	29-37	interleukin 1 beta	Mus musculus	156-164
25805930-7	2015	Urantide pretreatment inhibited the degree of TNF-alpha and IL-1beta increase following downregulation of UII post-challenge (all P &lt; 0.05).	urotensin II (4-11), Pen(5)-Trp(7)-Orn(8)-	0-8	interleukin 1 beta	Mus musculus	60-68
25681768-0	2015	Extracellular ATP induces P2X7 receptor activation in mouse Kupffer cells, leading to release of IL-1beta, HMGB1, and PGE2, decreased MHC class I expression and necrotic cell death.	Adenosine Triphosphate	14-17	interleukin 1 beta	Mus musculus	97-105
25681768-4	2015	Treatment of LPS-primed Kupffer cells with 3 mM ATP induced Ca(2+) influx, non-selective large pore formation, activation of MAPK, cell lysis, IL-1beta release, prostaglandin E2 (PGE2) release, high mobility group box1 (HMGB1) release, and major histocompatibility complex (MHC) class I shedding.	Adenosine Triphosphate	48-51	interleukin 1 beta	Mus musculus	143-151
25852553-11	2015	IL-1beta did not alter ethanol"s enhancement of the eIPSP amplitude, but, in IL-1beta-responsive neurons, the ethanol effects on mIPSC frequencies were lost.	Ethanol	110-117	interleukin 1 beta	Mus musculus	77-85
25793995-5	2015	Here we demonstrate that high glucose significantly downregulates both the mRNA and protein levels of SIRT1 and upregulates the mRNA level and the release of two pro-inflammatory cytokines, IL-1beta and TNF-alpha, in RAW264.7 macrophages.	Glucose	30-37	interleukin 1 beta	Mus musculus	190-198
25852553-12	2015	Overall, our data suggest that the IL-1 system is involved in basal GABAergic transmission and that IL-1beta interacts with the ethanol-induced facilitation of CeA GABAergic transmission.	Ethanol	128-135	interleukin 1 beta	Mus musculus	100-108
25793995-7	2015	However, when the function of SIRT1 is inhibited by EX527 or its expression is suppressed by RNAi, the upregulated level and release of IL-1beta and TNF-alpha by high glucose are further increased.	Glucose	167-174	interleukin 1 beta	Mus musculus	136-144
25681332-5	2015	Instead, 15d-PGJ2 prevents the autoproteolytic activation of caspase-1 and the maturation of IL-1beta through induction of a cellular state inhibitory to caspase-1 proteolytic function.	15-deoxy-delta(12,14)-prostaglandin J2	9-17	interleukin 1 beta	Mus musculus	93-101
25681332-8	2015	In a mouse peritonitis model of gout, using monosodium urate crystals to activate NLRP3, 15d-PGJ2 caused a significant inhibition of cell recruitment and associated IL-1beta release.	Uric Acid	44-60	interleukin 1 beta	Mus musculus	165-173
25681332-8	2015	In a mouse peritonitis model of gout, using monosodium urate crystals to activate NLRP3, 15d-PGJ2 caused a significant inhibition of cell recruitment and associated IL-1beta release.	15-deoxy-delta(12,14)-prostaglandin J2	89-97	interleukin 1 beta	Mus musculus	165-173
25680460-0	2015	Amyloid beta oligomers induce interleukin-1beta production in primary microglia in a cathepsin B- and reactive oxygen species-dependent manner.	Reactive Oxygen Species	102-125	interleukin 1 beta	Mus musculus	30-47
25680460-8	2015	Abeta oligomer-induced IL-1beta production was inhibited not only by the cathepsin B inhibitor CA-074-Me but also by the reactive oxygen species (ROS) inhibitor N-acetylcysteine.	CA 074 methyl ester	95-104	interleukin 1 beta	Mus musculus	23-31
25680460-8	2015	Abeta oligomer-induced IL-1beta production was inhibited not only by the cathepsin B inhibitor CA-074-Me but also by the reactive oxygen species (ROS) inhibitor N-acetylcysteine.	Reactive Oxygen Species	121-144	interleukin 1 beta	Mus musculus	23-31
25680460-8	2015	Abeta oligomer-induced IL-1beta production was inhibited not only by the cathepsin B inhibitor CA-074-Me but also by the reactive oxygen species (ROS) inhibitor N-acetylcysteine.	Reactive Oxygen Species	146-149	interleukin 1 beta	Mus musculus	23-31
25680460-8	2015	Abeta oligomer-induced IL-1beta production was inhibited not only by the cathepsin B inhibitor CA-074-Me but also by the reactive oxygen species (ROS) inhibitor N-acetylcysteine.	Acetylcysteine	161-177	interleukin 1 beta	Mus musculus	23-31
25680460-11	2015	These results indicate that Abeta oligomers, but not fibrils, induce IL-1beta production in primary microglia in a cathepsin B- and ROS-dependent manner.	Reactive Oxygen Species	132-135	interleukin 1 beta	Mus musculus	69-77
25578230-7	2015	PHMG-phosphate induced pro-inflammatory cytokines including IL-1beta, IL-6, and IL-8.	polyhexamethyleneguanidine	0-14	interleukin 1 beta	Mus musculus	60-68
25811992-7	2015	We demonstrated that ABL treatment significantly reduced neurological deficits and cerebral infarct volume by inhibiting tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) expression in ischemic cerebral tissue and OGD-treated BV2 cells.	lauric acid	21-24	interleukin 1 beta	Mus musculus	165-182
25811992-7	2015	We demonstrated that ABL treatment significantly reduced neurological deficits and cerebral infarct volume by inhibiting tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) expression in ischemic cerebral tissue and OGD-treated BV2 cells.	lauric acid	21-24	interleukin 1 beta	Mus musculus	184-192
25811992-8	2015	Mechanistic studies suggested that the observed decrease in TNF-alpha and IL-1beta expression was attributable to the ABL-induced suppression of the expression of nuclear factor-kappa B (NF-kappaB) and Toll-like receptor 4 (TLR4).	lauric acid	118-121	interleukin 1 beta	Mus musculus	74-82
25811992-9	2015	We further found that miR-155 promoted TNF-alpha and IL-1beta expression by upregulating TLR4 and downregulating the expression of suppressor of cytokine signaling 1 (SOCS1) and myeloid differentiation primary response gene 88 (MyD88), while ABL exerted an inhibitory effect on miR-155-mediated gene expression.	lauric acid	242-245	interleukin 1 beta	Mus musculus	53-61
25620130-8	2015	The results showed that acanthoic acid downregulated LPS-induced TNF-alpha, IL-6 and IL-1beta production in BALF.	acanthoic acid	24-38	interleukin 1 beta	Mus musculus	85-93
25620130-11	2015	In vitro, acanthoic acid inhibited inflammatory cytokines TNF-alpha, IL-6 and IL-1beta production and NF-kappaB activation in LPS-stimulated alveolar macrophages.	acanthoic acid	10-24	interleukin 1 beta	Mus musculus	78-86
25463220-5	2015	The data suggest that compare with raw MWCNTs and MWCNTs-PEG, the MWCNTs-COOH produces a significant increase in ROS generation, interruption of ATP synthesis, and activation of the MAPK and NF-kappaB signaling pathways, which in turn upregulates IL-1beta, IL-6, TNF-alpha, and iNOS to trigger cell death.	Polyethylene Glycols	57-60	interleukin 1 beta	Mus musculus	247-255
25463220-5	2015	The data suggest that compare with raw MWCNTs and MWCNTs-PEG, the MWCNTs-COOH produces a significant increase in ROS generation, interruption of ATP synthesis, and activation of the MAPK and NF-kappaB signaling pathways, which in turn upregulates IL-1beta, IL-6, TNF-alpha, and iNOS to trigger cell death.	Carbonic Acid	73-77	interleukin 1 beta	Mus musculus	247-255
25463220-5	2015	The data suggest that compare with raw MWCNTs and MWCNTs-PEG, the MWCNTs-COOH produces a significant increase in ROS generation, interruption of ATP synthesis, and activation of the MAPK and NF-kappaB signaling pathways, which in turn upregulates IL-1beta, IL-6, TNF-alpha, and iNOS to trigger cell death.	Reactive Oxygen Species	113-116	interleukin 1 beta	Mus musculus	247-255
25703036-8	2015	RESULTS: In EtOH-treated animals compared with controls, cytokines interleukin-1beta and tumor necrosis factor-alpha mRNA levels were increased significantly in the hippocampus, cerebellum, and cerebral cortex.	Ethanol	12-16	interleukin 1 beta	Mus musculus	67-116
26045742-9	2015	The expression of IL-1beta, TNF-alpha, TLR2 and p-NF-kappaB and iNOS were lower after fasudil treatment (P&lt;0.05) while the expression of arginase1 was increased (P&lt;0.05).	fasudil	86-93	interleukin 1 beta	Mus musculus	18-26
25472006-8	2015	Treatment of DBA/2 susceptible mice with inflammasome inducers (i.e. nigericin and ATP) artificially increased pyroptosis and lowered the levels of NF-kappaB-related inflammatory cytokines, but restored IL-1beta to levels similar to those in C57BL/6 mice.	Nigericin	69-78	interleukin 1 beta	Mus musculus	203-211
25472006-8	2015	Treatment of DBA/2 susceptible mice with inflammasome inducers (i.e. nigericin and ATP) artificially increased pyroptosis and lowered the levels of NF-kappaB-related inflammatory cytokines, but restored IL-1beta to levels similar to those in C57BL/6 mice.	Adenosine Triphosphate	83-86	interleukin 1 beta	Mus musculus	203-211
25583024-5	2015	Antrodan significantly increased interleukin (IL)-12 and IL-1beta levels, but decreased TNF-alpha, IL-6 and IL-8 levels in the MMC-CM, which also significantly inhibited invasion, migration, and the activities and protein expression of MMP-2 and MMP-9, but significantly increased protein expression of TIMP-1, TIMP-2, and nm23-H1 in LLC cells.	antrodan	0-8	interleukin 1 beta	Mus musculus	57-65
25303960-2	2015	Macrophage-secreted factors including proinflammatory cytokines, tumor necrosis factor-alpha and interleukin-1beta, in adipose tissues have been known to limit the local adipogenesis and induce insulin resistance; however, the interplay between adipocytes and macrophages upon regulation of GM3 expression is not clear.	gm3	291-294	interleukin 1 beta	Mus musculus	97-114
25623334-6	2015	In the collagenase-induced ICH model, misoprostol decreased cellular inflammatory response; attenuated oxidative brain damage and gelatinolytic activity; and decreased high-mobility group box 1 (HMGB1) expression, Src kinase activity, and interleukin-1beta expression without affecting cyclooxygenase-2 expression.	Misoprostol	38-49	interleukin 1 beta	Mus musculus	214-256
25550199-7	2015	NO-induced muscle relaxation was inhibited in longitudinal muscle cells isolated from muscle strips cultured with IL-1beta or TNF-alpha or obtained from the colon of TNBS-treated mice, and this inhibition was completely reversed by the combination of both 1400W and vinpocetine.	vinpocetine	266-277	interleukin 1 beta	Mus musculus	114-122
25519169-9	2015	Furthermore, during DEN-induced initiation of HCC, Ct-HBx- and FL-HBx-transgenic mice showed higher expression of IL-6, TNF-alpha and IL-1beta transcripts, activation of STAT3, ERK and JNK proteins and an increase in cell apoptosis.	Diethylnitrosamine	20-23	interleukin 1 beta	Mus musculus	134-142
25686106-10	2015	In vivo, BHB or a ketogenic diet attenuates caspase-1 activation and IL-1beta secretion in mouse models of NLRP3-mediated diseases such as Muckle-Wells syndrome, familial cold autoinflammatory syndrome and urate crystal-induced peritonitis.	3-Hydroxybutyric Acid	9-12	interleukin 1 beta	Mus musculus	69-77
25866750-5	2015	TMC (500 mg/kg BW) reduced hepatic mRNA levels of TNF-alpha, IL-1beta, IL-6, COX-2, and iNOS by 87%, 84%, 89%, 85%, and 88%, respectively, in mice treated with APAP (P&lt;0.05).	tmc	0-3	interleukin 1 beta	Mus musculus	61-69
25661072-6	2015	We report that GlcCer inhibited messenger RNA and protein expression of tissue necrosis factor alpha and interleukin 1beta without cytotoxicity.	Glucosylceramides	15-21	interleukin 1 beta	Mus musculus	105-122
26226733-13	2015	Moreover, the expression of IL-1beta and mPGES-1 was decreased after Guizhi Fuling capsule and active complex treatment, which might contribute to the inhibitory effect of Guizhi Fuling capsule in the releasing of IL-1beta, TNF-alpha and PGE2.	Dinoprostone	238-242	interleukin 1 beta	Mus musculus	28-36
25582856-6	2015	In vivo, in a monosodium urate crystal (MSU)-induced NLRP3-dependent peritonitis model, MSU-induced IL-1beta production and neutrophil flux were significantly reduced in beta-arrestin1 knockout mice.	monosodium urate crystal	14-38	interleukin 1 beta	Mus musculus	100-108
25548278-2	2015	Recent investigations suggest the possible role of NLRP3 inflammasomes, which regulate IL-1beta production and lead to inflammatory responses, in the pathophysiology of HALI; however, their role is not fully understood.	hali	169-173	interleukin 1 beta	Mus musculus	87-95
25692549-6	2015	RESULTS: In the N group, probiotics, KRG, and urushiol significantly reduced levels of TNF-alpha (12.3+-5.1, 13.4+-3.9, and 12.1+-4.3 vs. 27.9+-15.2 pg/mL) and IL-1beta (108.4+-39.4, 75.0+-51.0, and 101.1+-26.8 vs. 162.4+-37.5 pg/mL), which were increased by alcohol.	CHEMBL1828984	37-40	interleukin 1 beta	Mus musculus	160-168
25692549-6	2015	RESULTS: In the N group, probiotics, KRG, and urushiol significantly reduced levels of TNF-alpha (12.3+-5.1, 13.4+-3.9, and 12.1+-4.3 vs. 27.9+-15.2 pg/mL) and IL-1beta (108.4+-39.4, 75.0+-51.0, and 101.1+-26.8 vs. 162.4+-37.5 pg/mL), which were increased by alcohol.	urushiol	46-54	interleukin 1 beta	Mus musculus	160-168
25617481-7	2015	Mechanistically, HMC inhibited carrageenan-induced cytokine (TNF-alpha, IL-1beta, IL-6, and IL-10) production, oxidative stress and NF-kappaB activation.	Carrageenan	31-42	interleukin 1 beta	Mus musculus	72-80
25582856-6	2015	In vivo, in a monosodium urate crystal (MSU)-induced NLRP3-dependent peritonitis model, MSU-induced IL-1beta production and neutrophil flux were significantly reduced in beta-arrestin1 knockout mice.	msu	40-43	interleukin 1 beta	Mus musculus	100-108
25584775-8	2015	G-CSF-induced hyperalgesia was dose-dependently inhibited by thalidomide (5-45mg/kg) and pentoxifylline (0.5-13.5mg/kg), and treatment with these drugs inhibited G-CSF-induced TNFalpha, IL-1beta and IL-10 production.	Pentoxifylline	89-103	interleukin 1 beta	Mus musculus	186-194
25681154-11	2015	In naproxen-induced gastric damage, FOR0810 prevented gastric injury, decreased gastric MPO activity and leukocyte adherence, associated with a decrease in TNFalpha and IL-1beta gastric concentrations.	Naproxen	3-11	interleukin 1 beta	Mus musculus	169-177
25644393-10	2015	DFO prevented LPS-induced microglial activation and elevations of IL-1beta and TNF-alpha levels in the hippocampus.	Deferoxamine	0-3	interleukin 1 beta	Mus musculus	66-74
25663772-11	2015	Down-regulation of IL-22, IL-17A, IFN-gamma, TNF-alpha, IL-6, IL-1beta, AHR RORgammat, and T-bet gene expression in the liver was observed in the rmIL-22 group (P &lt; 0.01).	rmil	146-150	interleukin 1 beta	Mus musculus	62-70
25527144-5	2015	The pro-inflammatory cytokine, IL-1beta, and neutrophils in bronchoalveolar lavage fluid (BALF) increased following intratracheal instillation of AgNPs or AgNO3.	Silver Nitrate	155-160	interleukin 1 beta	Mus musculus	31-39
25458285-5	2015	Both polysaccharides were found to stimulate NO production and induce the expression of cytokine mRNAs including IL-1beta, IL-6, IL-10 and TNF-alpha on RAW264.7 cells.	Polysaccharides	5-20	interleukin 1 beta	Mus musculus	113-121
25530164-11	2015	Lipopolysaccharides markedly increased the expression and secretion of IL-1beta, IL-6, IL-8, and TNF-alpha in the GECs cultured in high glucose medium, which was also partly blocked in the presence of RSV.	Glucose	136-143	interleukin 1 beta	Mus musculus	71-79
25530164-11	2015	Lipopolysaccharides markedly increased the expression and secretion of IL-1beta, IL-6, IL-8, and TNF-alpha in the GECs cultured in high glucose medium, which was also partly blocked in the presence of RSV.	Resveratrol	201-204	interleukin 1 beta	Mus musculus	71-79
25605419-9	2015	17beta-E2 markedly decreased the ROS production induced by Hcy, the expression of TNF-alpha and IL-1beta at protein and mRNA levels, and down-regulated the phosphorylation of MAPKs (ERK1/2, JNK and p38).	17beta-e2	0-9	interleukin 1 beta	Mus musculus	96-104
25530164-9	2015	RSV administration also suppressed the high levels of IL-1beta, IL-6, IL-8, TNF-alpha, and TLR4 in gingival tissue of the mice.	Resveratrol	0-3	interleukin 1 beta	Mus musculus	54-62
24964914-6	2015	Topical treatment with all three doses of E-AP-SM2001 and 5 nm myricetin attenuated the UV-induced depletion of GSH, activation of MMPs, production of IL-1beta, the decrease in IL-10 and keratinocyte apoptosis.	e-ap-sm2001	42-53	interleukin 1 beta	Mus musculus	151-159
24964914-6	2015	Topical treatment with all three doses of E-AP-SM2001 and 5 nm myricetin attenuated the UV-induced depletion of GSH, activation of MMPs, production of IL-1beta, the decrease in IL-10 and keratinocyte apoptosis.	myricetin	63-72	interleukin 1 beta	Mus musculus	151-159
25377620-8	2015	Ondansetron inhibited expression of the chemokine CCL2, IL-1beta, IL-6, TNF-alpha and iNOS mRNAs up-regulated by IM, and also ameliorated the delayed gastrointestinal transit.	Ondansetron	0-11	interleukin 1 beta	Mus musculus	56-64
25218901-7	2015	The exacerbation of sickness behavior induced by FK565 or MDP in combination with LPS was paralleled by enhanced plasma protein and cerebral mRNA levels of proinflammatory cytokines (IFN-gamma, IL-1beta, IL-6, TNF-alpha) as well as enhanced plasma levels of kynurenine.	heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine	49-54	interleukin 1 beta	Mus musculus	194-202
25173887-9	2015	The results showed that magnolol significantly inhibit the LPS-induced TNF-alpha, IL-6, and IL-1beta production both in vivo and vitro.	magnolol	24-32	interleukin 1 beta	Mus musculus	92-100
25519469-10	2015	Thiram (2 microg/mL) decreased NF-kappaB activation and production of LPS-induced IL-1beta.	Thiram	0-6	interleukin 1 beta	Mus musculus	82-90
25574840-9	2015	FASN inhibition by shRNA and treatment with the chemical inhibitors C75 and cerulenin suppressed NLRP3-mediated caspase-1 activation and inhibited NLRP3 and pro-IL-1beta gene expression in macrophages.	Cerulenin	76-85	interleukin 1 beta	Mus musculus	161-169
25523461-4	2015	Protein and mRNA levels of DSS-induced pro-inflammatory cytokines in colon, including TNF-alpha, IL-1beta, IL-6 and IFN-gamma, were markedly suppressed by asiatic acid.	Dextran Sulfate	27-30	interleukin 1 beta	Mus musculus	97-105
25523461-4	2015	Protein and mRNA levels of DSS-induced pro-inflammatory cytokines in colon, including TNF-alpha, IL-1beta, IL-6 and IFN-gamma, were markedly suppressed by asiatic acid.	asiatic acid	155-167	interleukin 1 beta	Mus musculus	97-105
25523461-6	2015	In addition, we also found that asiatic acid dose-dependently inhibited IL-1beta secretion, caspase-1 activation as well as inflammasome assembling in vitro.	asiatic acid	32-44	interleukin 1 beta	Mus musculus	72-80
25338942-9	2015	In the in vitro experiments, IL-1beta and IL-18 secreted from RAW264.7 mouse macrophages treated with paraquat were attenuated by glybenclamide.	Paraquat	102-110	interleukin 1 beta	Mus musculus	29-37
25338942-9	2015	In the in vitro experiments, IL-1beta and IL-18 secreted from RAW264.7 mouse macrophages treated with paraquat were attenuated by glybenclamide.	Glyburide	130-143	interleukin 1 beta	Mus musculus	29-37
25404465-9	2015	Finally, RT-PCR data revealed that olaparib downregulates the LPS-induced expression of NF-kappaB-dependent genes namely TNF-alpha, IL-1beta, and VCAM-1 in the lungs without altering the expression of total p65NF-kappaB.	olaparib	35-43	interleukin 1 beta	Mus musculus	132-140
25472814-6	2015	Pretreatment with PD98059, a MEK1/2 inhibitor, significantly reduced P4BSA-induced expression of mRNA of Il1B, Tnf, and Ptgs2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	18-25	interleukin 1 beta	Mus musculus	105-109
25446779-4	2015	We used WT, TLR4-KO and TLR2-KO mice treated with alcohol for 5 months to show that chronic ethanol consumption increases the levels of cytokines (IL-1beta, IL-17, TNF-alpha) and chemokines (MCP-1, MIP-1alpha, CX3CL1) in the striatum and serum (MCP-1, MIP-1alpha, CX3CL1) of WT mice.	Ethanol	92-99	interleukin 1 beta	Mus musculus	147-155
24854198-5	2015	Moreover, the extensive astrogliosis and microgliosis as well as the increased expression in interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the hippocampus and cortex of APP/PS1 transgenic mice were significantly reduced following administration of VPA, which attenuated neuronal degeneration.	Valproic Acid	278-281	interleukin 1 beta	Mus musculus	93-110
25261783-4	2015	The results indicate that geniposide treatment significantly suppresses RAGE-dependent signaling (activation of ERK and IkappaB/NF-kappaB), the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) and cerebral Abeta accumulation in vivo.	geniposide	26-36	interleukin 1 beta	Mus musculus	202-219
25446779-5	2015	Alcohol deprivation for 24 h induces IFN-gamma levels in the striatum and maintains high levels of some cytokines (IL-1beta, IL-17) and chemokines (MIP-1alpha, CX3CL1) in this brain region.	Alcohols	0-7	interleukin 1 beta	Mus musculus	115-123
25635685-6	2015	As compared to animals receiving Vanco, LZD group had significantly lower numbers of neutrophils in the BAL (9x10(3) vs. 2.3x10(4), p &lt; 0.01), which was associated with reduced levels of chemotactic chemokines and inflammatory cytokines KC, MIP-2, IFN-gamma, TNF-alpha and IL-1beta in the BAL.	Linezolid	40-43	interleukin 1 beta	Mus musculus	276-284
25528385-12	2015	CYN exposure increased mechanical components, alveolar collapse, PMN cells and fiber deposition in the lungs, as well as the production of IL-1beta, IL-6 and KC in Protocol #1.	cylindrospermopsin	0-3	interleukin 1 beta	Mus musculus	139-147
25603858-8	2015	Pretreatment with the NLRP3 inflammasome inhibitor VX-765 decreased serum and hippocampal levels of interleukin-1beta protein and significantly moderated the depressive-like behaviors induced by chronic mild stress.	belnacasan	51-57	interleukin 1 beta	Mus musculus	100-117
25617057-0	2015	Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1beta-induced catabolic gene expression in cartilage.	arthropod steroid hormone	0-25	interleukin 1 beta	Mus musculus	58-66
25617057-0	2015	Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1beta-induced catabolic gene expression in cartilage.	Ecdysterone	27-45	interleukin 1 beta	Mus musculus	58-66
25499818-1	2015	Nuciferine, a major aporphine alkaloid of the leaves of Nelumbo nucifera, was found to decrease serum urate levels and improved kidney function, as well as inhibited system and renal interleukin-1beta (IL-1beta) secretion in potassium oxonate-induced hyperuricemic mice.	nuciferine	0-10	interleukin 1 beta	Mus musculus	202-210
25281205-7	2015	In vitro, citral inhibited LPS-induced TNF-alpha, IL-6 and IL-1beta production in alveolar macrophages.	citral	10-16	interleukin 1 beta	Mus musculus	59-67
25281205-6	2015	The results showed that pretreatment with citral remarkably attenuated pulmonary edema, histological severities, TNF-alpha, IL-6 and IL-1beta production in LPS-induced ALI in vivo.	citral	42-48	interleukin 1 beta	Mus musculus	133-141
25499818-3	2015	More importantly, nuciferine suppressed renal activation of Toll-like receptor 4/myeloid differentiation factor 88/NF-kappaB (TLR4/MyD88/NF-kappaB) signaling and NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome to reduce serum and renal IL-1beta levels in hyperuricemic mice with renal inflammation reduction.	nuciferine	18-28	interleukin 1 beta	Mus musculus	261-269
25593461-6	2015	Expression levels of IL-6, IL-1beta, interferon (IFN)-gamma and MMP-9 were decreased in the colons of mice exposed to butein, whereas other inflammatory cytokines (IL-17A, IL-21 and IL-22) were unchanged.	butein	118-124	interleukin 1 beta	Mus musculus	27-35
25478868-7	2015	Thalidomide pretreatment significantly reduced the levels of pro-inflammatory cytokines [tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6], malondialdehyde (MDA) and myeloperoxidase (MPO) activity.	Thalidomide	0-11	interleukin 1 beta	Mus musculus	124-146
25569097-6	2015	PW showed anti-inflammatory effects by inhibiting the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) and interleukin-1beta (IL-1beta).	H-Pro-Trp-OH	0-2	interleukin 1 beta	Mus musculus	156-173
25569097-6	2015	PW showed anti-inflammatory effects by inhibiting the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) and interleukin-1beta (IL-1beta).	H-Pro-Trp-OH	0-2	interleukin 1 beta	Mus musculus	175-183
25449599-8	2015	While, the inhibition of TNF-alpha and IL-1beta secretion was another reason for the suppressive effect of myricetin on Ti particle-induced osteolysis.	myricetin	107-116	interleukin 1 beta	Mus musculus	39-47
26517816-10	2015	In ex-vivo study, LPS induced prominent production of IL-1beta and MCP-1 in cultured RAW264.7 cells, which was significantly suppressed by rapamycin.	Sirolimus	139-148	interleukin 1 beta	Mus musculus	54-62
26351625-7	2015	Regarding the analgesic mechanisms of quercetin, it inhibited the production of hyperalgesic cytokines IL-1beta and TNFalpha and decreased neutrophil recruitment (myeloperoxidase activity) and oxidative stress.	Quercetin	38-47	interleukin 1 beta	Mus musculus	103-111
25640393-9	2015	The animal model demonstrated that magnesium sulfate induced production of IL-1beta, IL-6, and TNF-alpha.	Magnesium Sulfate	35-52	interleukin 1 beta	Mus musculus	75-83
26061908-7	2015	As compared to WT littermates, atg5(-/-) mice exposed to chronic carbon tetrachloride administration displayed higher hepatic levels of IL1A and IL1B and enhanced inflammatory cell recruitment associated with exacerbated liver injury.	Carbon Tetrachloride	65-85	interleukin 1 beta	Mus musculus	145-149
26061908-9	2015	Macrophages from atg5(-/-) mice secreted higher levels of reactive oxygen species (ROS)-induced IL1A and IL1B.	Reactive Oxygen Species	58-81	interleukin 1 beta	Mus musculus	105-109
26061908-9	2015	Macrophages from atg5(-/-) mice secreted higher levels of reactive oxygen species (ROS)-induced IL1A and IL1B.	Reactive Oxygen Species	83-86	interleukin 1 beta	Mus musculus	105-109
25378412-8	2015	In vitro experiments revealed that angiotensin II stimulated the NLRP3 inflammasome activation and subsequent interleukin-1beta release in macrophages, and this activation was mediated through an angiotensin type I receptor/mitochondria-derived reactive oxygen species-dependent pathway.	Reactive Oxygen Species	245-268	interleukin 1 beta	Mus musculus	110-127
26043790-9	2015	Increased autophagy contributes to cocaine-mediated activation of microglia since pretreatment of cells with wortmannin resulted in decreased expression and release of inflammatory factors (TNF, IL1B, IL6, and CCL2) in microglial cells.	Wortmannin	109-119	interleukin 1 beta	Mus musculus	195-199
25102452-10	2015	Minocycline administration reduced tumor-induced expression of IL-1beta in the brain, reduced depressive-like behavior, and improved grip strength without altering muscle mass.	Minocycline	0-11	interleukin 1 beta	Mus musculus	63-71
26064905-9	2015	Moreover, 10 mg/kg NaB treatment markedly restored the levels of MDA, SOD, IL-1beta, TNF-alpha, and IL-8.	nab	19-22	interleukin 1 beta	Mus musculus	75-83
25890744-0	2015	Anti-inflammatory activity of curcumin-loaded solid lipid nanoparticles in IL-1beta transgenic mice subjected to the lipopolysaccharide-induced sepsis.	Curcumin	30-38	interleukin 1 beta	Mus musculus	75-83
26339604-7	2015	We observed that proinflammatory IL-1beta and also CXCL1 were highly upregulated whereas anti-inflammatory or regulatory cytokines IL-6 and IL-10 were suppressed by 10 microM Cd.	Cadmium	175-177	interleukin 1 beta	Mus musculus	33-41
26159678-9	2015	In addition, Escin decreased the level of the pro-inflammatory cytokinesTNF-alpha,IL-1beta, IL-6 and HMGB1 in endotoxemic mice and in LPS-induced macrophages.	Escin	13-18	interleukin 1 beta	Mus musculus	82-90
25591776-9	2015	RESULTS: PM treatment significantly decreased circulating EPC population, promoted apoptosis of EPCs in association with increased ROS production and serum TNF-alpha and IL-1beta levels, which could be effectively reversed by either NAC treatment or overexpression of AON.	Acetylcysteine	233-236	interleukin 1 beta	Mus musculus	170-178
25967960-7	2015	RESULTS: The combination of sodium alginate and resveratrol significantly reduced synovial levels of IL-1beta, CCR5, and CXCL10 when compared with colchicines, and all P values were less than 0.0001.	Alginates	28-43	interleukin 1 beta	Mus musculus	101-109
25967960-7	2015	RESULTS: The combination of sodium alginate and resveratrol significantly reduced synovial levels of IL-1beta, CCR5, and CXCL10 when compared with colchicines, and all P values were less than 0.0001.	Resveratrol	48-59	interleukin 1 beta	Mus musculus	101-109
25967960-8	2015	The combination of sodium alginate and resveratrol was also superior to resveratrol in terms of both serum levels and synovial levels of IL-1beta, CCR5, and CXCL10.	Alginates	19-34	interleukin 1 beta	Mus musculus	137-145
25967960-8	2015	The combination of sodium alginate and resveratrol was also superior to resveratrol in terms of both serum levels and synovial levels of IL-1beta, CCR5, and CXCL10.	Resveratrol	39-50	interleukin 1 beta	Mus musculus	137-145
25967960-8	2015	The combination of sodium alginate and resveratrol was also superior to resveratrol in terms of both serum levels and synovial levels of IL-1beta, CCR5, and CXCL10.	Resveratrol	72-83	interleukin 1 beta	Mus musculus	137-145
25385303-8	2015	RESULTS: ANP treatment significantly attenuated cisplatin-induced increases in serum blood urea nitrogen and creatinine, urine albumin/creatinine, and renal expression of IL-1beta, IL-6, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1 mRNAs.	Cisplatin	48-57	interleukin 1 beta	Mus musculus	171-179
26159678-11	2015	The release of the pro-inflammatory cytokinesTNF-alpha,IL-1beta, IL-6 could be suppressed in rHMGB1-induced macrophages by Escin.	Escin	123-128	interleukin 1 beta	Mus musculus	55-63
25528414-8	2015	In addition, the serum levels of tumor necrosis factor alpha (TNFalpha), interleukin 6 (IL6) and interleukin 1beta (IL1beta) increased significantly in the groups treated with 30mg/L CdCl2 for 21 days.	Cadmium Chloride	183-188	interleukin 1 beta	Mus musculus	97-114
26279426-6	2015	RESULTS: Elevated levels of IL-1beta, alphavbeta6 and TGF-beta1 were each associated with aberrant elastin production in O2-exposed lungs.	Oxygen	121-123	interleukin 1 beta	Mus musculus	28-36
24730395-10	2015	Further, the reduced secretion of IL-1beta correlated with reduced nuclear translocation of nuclear factor (NF)-kappaB p65, starting at exposure of pMPhi to 0 5 Gy of X-irradiation.	pmphi	148-153	interleukin 1 beta	Mus musculus	34-42
26777707-9	2015	Hemin up regulated NLRP3 and IL-1b level, which was reversed by MK801 (NMDAR antagonist) in vitro.	Dizocilpine Maleate	64-69	interleukin 1 beta	Mus musculus	29-34
25528414-8	2015	In addition, the serum levels of tumor necrosis factor alpha (TNFalpha), interleukin 6 (IL6) and interleukin 1beta (IL1beta) increased significantly in the groups treated with 30mg/L CdCl2 for 21 days.	Cadmium Chloride	183-188	interleukin 1 beta	Mus musculus	116-123
26779276-6	2015	Treatment with DHYW markedly decreased the levels of interleukin-6 (IL-6), IL-1beta, and tumor necrosis factor-alpha (TNF-alpha).	dhyw	15-19	interleukin 1 beta	Mus musculus	75-83
25866535-7	2015	At the same time, MAG reduced the number of inflammatory cells in lung and inhibited the production of TNF-alpha and IL-1beta in BALF.	mag	18-21	interleukin 1 beta	Mus musculus	117-125
25691908-5	2015	Inflammatory cytokines including TNF-alpha, IL-1beta, and IL-6 were notably increased in hepatic tissues, and then these were efficiently attenuated by TCW pretreatment.	Tolcapone	152-155	interleukin 1 beta	Mus musculus	44-52
25460360-5	2015	Selenium deficiency also exacerbated UVB-induced cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 mRNA expressions.	Selenium	0-8	interleukin 1 beta	Mus musculus	156-173
25053100-2	2015	Treatment with trilobatin (0.005-5 muM) dose-dependently inhibited the lipopolysaccharide (LPS)-induced mRNA expression and secretion of pro-inflammatory cytokines, including tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6), in RAW 264.7 macrophages.	trilobatin	15-25	interleukin 1 beta	Mus musculus	215-232
25053100-2	2015	Treatment with trilobatin (0.005-5 muM) dose-dependently inhibited the lipopolysaccharide (LPS)-induced mRNA expression and secretion of pro-inflammatory cytokines, including tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6), in RAW 264.7 macrophages.	trilobatin	15-25	interleukin 1 beta	Mus musculus	234-242
25460360-5	2015	Selenium deficiency also exacerbated UVB-induced cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 mRNA expressions.	Selenium	0-8	interleukin 1 beta	Mus musculus	175-183
25420215-4	2015	The expressed TatM013 protein was secreted and blocked the endotoxin-induced secretion of interleukin (IL)-1beta in monocyte-derived cells and the reactive aldehyde-induced secretion of IL-1beta in retinal pigment epithelium cells.	Aldehydes	156-164	interleukin 1 beta	Mus musculus	186-194
25553444-5	2015	Furthermore, mice overexpressing miR-155 had higher levels of TNF-alpha and IL-1 beta in BALF when exposed to isoflurane after LPS challenge.Conversely, downregulation of miR-155 promoted isoflurane effects on HIF-1 alpha expression.	Isoflurane	110-120	interleukin 1 beta	Mus musculus	76-85
25553444-5	2015	Furthermore, mice overexpressing miR-155 had higher levels of TNF-alpha and IL-1 beta in BALF when exposed to isoflurane after LPS challenge.Conversely, downregulation of miR-155 promoted isoflurane effects on HIF-1 alpha expression.	Isoflurane	188-198	interleukin 1 beta	Mus musculus	76-85
26514440-3	2015	ES pretreatment at doses of 20 and 40 mg/kg effectively attenuated LPS-induced lung histopathological change, myeloperoxidase or MPO activity, inflammatory cells infiltration, pulmonary wet-to-dry weight ratio, and the generation of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) in vivo and in vitro.	esculetin	0-2	interleukin 1 beta	Mus musculus	311-328
26514440-3	2015	ES pretreatment at doses of 20 and 40 mg/kg effectively attenuated LPS-induced lung histopathological change, myeloperoxidase or MPO activity, inflammatory cells infiltration, pulmonary wet-to-dry weight ratio, and the generation of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) in vivo and in vitro.	esculetin	0-2	interleukin 1 beta	Mus musculus	330-338
25039377-5	2015	In contrast, two members of the dinitrohalobenezene family (2,4-dinitrochlorobenzene [DNCB] and 2,4-dinitrofluorobenzene [DNFB]) promoted LC migration independently of TNF-R2 (the sole TNF-alpha receptor expressed by LC) and TNF-alpha although the presence of IL-1beta was still required.	Dinitrofluorobenzene	122-126	interleukin 1 beta	Mus musculus	260-268
25502067-4	2015	Phenyl-beta-D-glucopyranoside also attenuated proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and other inflammation-related genes, such as IL-6 in a concentration-dependent manner.	phenylglucoside	0-29	interleukin 1 beta	Mus musculus	124-141
25039377-5	2015	In contrast, two members of the dinitrohalobenezene family (2,4-dinitrochlorobenzene [DNCB] and 2,4-dinitrofluorobenzene [DNFB]) promoted LC migration independently of TNF-R2 (the sole TNF-alpha receptor expressed by LC) and TNF-alpha although the presence of IL-1beta was still required.	dinitrohalobenezene	32-51	interleukin 1 beta	Mus musculus	260-268
25039377-5	2015	In contrast, two members of the dinitrohalobenezene family (2,4-dinitrochlorobenzene [DNCB] and 2,4-dinitrofluorobenzene [DNFB]) promoted LC migration independently of TNF-R2 (the sole TNF-alpha receptor expressed by LC) and TNF-alpha although the presence of IL-1beta was still required.	Dinitrochlorobenzene	60-84	interleukin 1 beta	Mus musculus	260-268
25039377-5	2015	In contrast, two members of the dinitrohalobenezene family (2,4-dinitrochlorobenzene [DNCB] and 2,4-dinitrofluorobenzene [DNFB]) promoted LC migration independently of TNF-R2 (the sole TNF-alpha receptor expressed by LC) and TNF-alpha although the presence of IL-1beta was still required.	Dinitrochlorobenzene	86-90	interleukin 1 beta	Mus musculus	260-268
25586484-4	2015	Resveratrol could significantly reduce the levels of pro-inflammatory factors TNF-alpha, IL-1beta, and IL-6 in serum (p&lt;0.01) and greatly elevate the expression level of SIRT1 (p&lt;0.01).	Resveratrol	0-11	interleukin 1 beta	Mus musculus	89-97
25577343-9	2015	The Se-deficient mice model was successfully replicated, and Se deficiency exacerbated uterine tissue histopathology; increased the expression of TNF-alpha, IL-1beta, and IL-6; facilitated the activation of TLR4; and enhanced the phosphorylation of IkappaBalpha, p65, ERK, JNK, and p38 in LPS-induced mice endometritis.	Selenium	4-6	interleukin 1 beta	Mus musculus	157-165
25502067-4	2015	Phenyl-beta-D-glucopyranoside also attenuated proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and other inflammation-related genes, such as IL-6 in a concentration-dependent manner.	phenylglucoside	0-29	interleukin 1 beta	Mus musculus	143-151
25621771-7	2015	Mechanistic studies revealed that the neuroprotective effects of FLZ were due to the suppression of neuroinflammation induced by LPS, as indicated by inactivation of astrocytes and microglia, reduced production of tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide, as well as decreased expression of cyclooxygenase-2 and inducible nitric oxide synthase.	flz	65-68	interleukin 1 beta	Mus musculus	243-260
26021324-11	2015	In parallel, suramin blocked DNCB-induced elevation in serum TNF-alpha, IL-1beta, IL-6 and IgE.	Suramin	13-20	interleukin 1 beta	Mus musculus	72-80
26021324-11	2015	In parallel, suramin blocked DNCB-induced elevation in serum TNF-alpha, IL-1beta, IL-6 and IgE.	Dinitrochlorobenzene	29-33	interleukin 1 beta	Mus musculus	72-80
26572172-8	2015	Exposure of mice with emphysema to CS exacerbated the pulmonary tissue damage, caused weight loss, significantly increased mortality, decreased T-AOC, elevated MDA contents in lung tissue, and increased interleukin (IL)-1beta levels in bronchoalveolar lavage (BAL) fluids (all p &lt; 0.05).	Cesium	35-37	interleukin 1 beta	Mus musculus	203-225
25908255-4	2015	The administration of Fasudil exhibited neuroprotective effects against the dopaminergic neurons and improved the motor function recovery in the MPTP-PD mice, accompanied by the suppression of inflammatory responses (IL-1beta, TNF-alpha, NF-kappaB-p65 and TLR-2), and oxidative stress (iNOS and gp91Phox), which might be associated with the inhibition of ROCK and GSK-3beta activity.	fasudil	22-29	interleukin 1 beta	Mus musculus	217-225
25441030-7	2015	We further demonstrate that bleomycin-induced BAFF expression and lung fibrosis were IL-1beta and IL-17A dependent.	Bleomycin	28-37	interleukin 1 beta	Mus musculus	85-93
24659563-7	2015	Immunohistochemical staining indicated that significantly more IL-1beta and TNF positive cells occurred in Ti and PMMA groups; while the UHMWPE group resulted in stronger positive MCP-1 and IL-6 stains.	Polymethyl Methacrylate	114-118	interleukin 1 beta	Mus musculus	63-71
24659563-8	2015	Polymerase chain reaction (PCR) confirmed overexpression of both IL-1beta and TNF in Ti and PMMA-stimulated groups; and more MIP-1alpha gene expression developed in the UHMWPE group.	Polymethyl Methacrylate	92-96	interleukin 1 beta	Mus musculus	65-73
25734767-2	2015	It was postulated that NGF mediates O3-induced IL-1beta effects on SP.	Ozone	36-38	interleukin 1 beta	Mus musculus	47-55
26626250-12	2015	The optimized cream showed no phase separation after 30 min centrifugation at 825 g. In the TPA-induced inflammation model, the resin formulation significantly reduced ear thickness and interleukin-1 beta levels in mouse ear tissue.	Tetradecanoylphorbol Acetate	92-95	interleukin 1 beta	Mus musculus	186-204
25734767-4	2015	The findings showed that in vivo O3 exposure induced an increase of all three proteins in mouse BALF and that O3-induced elevations in both NGF and SP are mediated by the inflammatory cytokine IL-1beta.	Ozone	33-35	interleukin 1 beta	Mus musculus	193-201
25734767-4	2015	The findings showed that in vivo O3 exposure induced an increase of all three proteins in mouse BALF and that O3-induced elevations in both NGF and SP are mediated by the inflammatory cytokine IL-1beta.	Ozone	110-112	interleukin 1 beta	Mus musculus	193-201
25734767-5	2015	Further, inhibition of NGF reduced O3 induced increases of SP in both the lung BALF and lung tissue, demonstrating NGF serves as a mediator of IL-1beta effects on SP.	Ozone	35-37	interleukin 1 beta	Mus musculus	143-151
25861160-7	2015	Moreover, the circulating TNF-alpha, renal TNF-alpha, IL-1beta, MCP-1, ICAM-1, and VACAM-1 mRNA levels were higher in the cisplatin-treated mice, compared with the controls, but they were attenuated in the OA-NO2 pretreatment group.	Cisplatin	122-131	interleukin 1 beta	Mus musculus	54-62
25653480-6	2015	The DNA-binding activity of NF-kappaB was suppressed and expression of several key inflammatory mediators including TNF-alpha, IL-1alpha, IL-1beta, IL-12, IL-17, and MCP-1 was lowered in the high-dose bortezomib-treated group.	Bortezomib	201-211	interleukin 1 beta	Mus musculus	138-146
25417010-8	2015	Notably, our data shows that an important property of TC is its capacity to exert cerebral anti-inflammatory effects by mitigating the expression of proinflammatory cytokines, such as TNF-alpha and IL-1beta.	caryophyllene	54-56	interleukin 1 beta	Mus musculus	198-206
26635450-6	2015	The 17C-6 mice have increased IL-1beta in plasma after chronic carbon tetrachloride (CCl4) administration compared to B6 mice.	Carbon Tetrachloride	63-83	interleukin 1 beta	Mus musculus	30-38
25323008-0	2015	Inhibitory effects of oligochitosan on TNF-alpha, IL-1beta and nitric oxide production in lipopolysaccharide-induced RAW264.7 cells.	oligochitosan	22-35	interleukin 1 beta	Mus musculus	50-58
25323008-3	2015	The results of the present study demonstrated that different concentrations of oligochitosan could significantly lower the levels of NO, tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta, released from LPS-stimulated RAW264.7 cells.	oligochitosan	79-92	interleukin 1 beta	Mus musculus	175-197
25323011-9	2015	Lycopene reduced the expression of TGF-beta1, collagen I, collagen III, TNF-alpha, IL-1beta, caspase-3, -8 and -9 and inhibited the activation of the NF-kappaB signaling pathway.	Lycopene	0-8	interleukin 1 beta	Mus musculus	83-91
25868617-14	2015	PIP dose dependently reduced histamine, NO concentration (p &lt; 0.001), as well as reduced expression of IL-6, IL-1beta, and IgE (p &lt; 0.001) as compared with the control group.	piperine	0-3	interleukin 1 beta	Mus musculus	112-120
26359675-6	2015	HP consumption also promoted collagen accumulation in the liver, and reduced numbers of proliferating hepatocytes and infiltrating inflammatory cells, as well as decreased expression of inflammatory factor interleukin-1beta, and nuclear factor kappaB activation.	Hematoporphyrins	0-2	interleukin 1 beta	Mus musculus	206-223
25551570-8	2014	Instillation of both bleomycin and Ad vectors increased expression levels of TNFalpha and IL-1beta but not IL-10.	Bleomycin	21-30	interleukin 1 beta	Mus musculus	90-98
25519833-4	2015	Pretreatment with bornyl cinnamate significantly inhibited lipopolysaccharide-induced proinflammatory molecules, including nitric oxide, prostaglandin-E2, tumor necrosis factor alpha, and interleukin-1beta production, in murine macrophage RAW 264.7 cells.	bornyl cinnamate	18-34	interleukin 1 beta	Mus musculus	188-205
26540118-5	2015	In addition, TB inhibited inflammatory cells and cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in BALF.	timosaponin B-II	13-15	interleukin 1 beta	Mus musculus	110-127
26540118-5	2015	In addition, TB inhibited inflammatory cells and cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in BALF.	timosaponin B-II	13-15	interleukin 1 beta	Mus musculus	129-137
25522817-2	2014	The inflammatory process induced by silica starts with the activation of the inflammasome, which leads to the release of mature IL-1beta.	Silicon Dioxide	36-42	interleukin 1 beta	Mus musculus	128-136
25561223-9	2014	At Day 10, the synergistic effect of BLM and ZnO exposure was detected on IL-1beta and monocyte chemotactic protein (MCP)-1 in BALF.	Zinc Oxide	45-48	interleukin 1 beta	Mus musculus	74-82
25522817-4	2014	Considering RBC lysis as a model of membrane damage, we evaluated the relationship between hemolytic activity and inflammasome-dependent release of IL-1beta for a panel of selected silica particles, in search of the toxicological significance of the hemolytic activity of an inhaled particle.	Silicon Dioxide	181-187	interleukin 1 beta	Mus musculus	148-156
25522817-5	2014	METHODS: Well-characterized silica particles, including four quartz samples and a vitreous silica, with different surface properties and hemolytic potential were tested for their capacity to induce inflammasome-dependent release of IL-1beta in LPS-primed primary murine peritoneal macrophages by ELISA and Western blot analysis.	Silicon Dioxide	28-34	interleukin 1 beta	Mus musculus	232-240
25522817-5	2014	METHODS: Well-characterized silica particles, including four quartz samples and a vitreous silica, with different surface properties and hemolytic potential were tested for their capacity to induce inflammasome-dependent release of IL-1beta in LPS-primed primary murine peritoneal macrophages by ELISA and Western blot analysis.	Silicon Dioxide	91-97	interleukin 1 beta	Mus musculus	232-240
25522817-7	2014	RESULTS: The silica samples induced dose-dependent hemolysis and IL-1beta release of different amplitudes.	Silicon Dioxide	13-19	interleukin 1 beta	Mus musculus	65-73
25722879-12	2014	SM intoxication also significantly increased the levels of pro-inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) and inhibited the level of anti-inflammatory cytokine IL-10.	Mustard Gas	0-2	interleukin 1 beta	Mus musculus	87-95
25522817-10	2014	CONCLUSIONS: The same physico-chemical properties of silica particles which are relevant for the lysis of the RBC membrane also appear implicated in the labilization of the phagolysosome, leading to inflammasome activation and release of the pro-inflammatory cytokine IL-1beta.	Silicon Dioxide	53-59	interleukin 1 beta	Mus musculus	268-276
25516005-9	2014	Articular cartilage in the EGCG-treated mice also exhibited reduced levels of MMP-1, -3, -8, -13, ADAMTS5, interleukin (IL)-1beta, and tumor necrosis factor (TNF)-alpha mRNA and elevated gene expression of the MMP regulator Cbp/p300 Interacting Transactivator 2 (CITED2).	epigallocatechin gallate	27-31	interleukin 1 beta	Mus musculus	107-129
25435139-2	2014	Here we show that IL-1beta-induced memory impairment in brain is mediated by hydrogen sulfide (H2S) synthesized by cystathionine beta-synthase (CBS).	Hydrogen Sulfide	77-93	interleukin 1 beta	Mus musculus	18-26
25435139-2	2014	Here we show that IL-1beta-induced memory impairment in brain is mediated by hydrogen sulfide (H2S) synthesized by cystathionine beta-synthase (CBS).	Hydrogen Sulfide	95-98	interleukin 1 beta	Mus musculus	18-26
25497724-1	2014	BACKGROUND: Inflammasome-activated IL-1beta plays a major role in lung neutrophilic inflammation induced by inhaled silica.	Silicon Dioxide	116-122	interleukin 1 beta	Mus musculus	35-43
25497724-6	2014	RESULTS: We found that the early release of IL-1alpha and IL-33, but not HMGB1 in alveolar space preceded the lung expression of pro-IL-1beta and neutrophilic inflammation in silica-treated mice.	Silicon Dioxide	175-181	interleukin 1 beta	Mus musculus	133-141
25515685-7	2014	The expression levels of IL-1beta, IL-6, F4/80, CCL2, and CXCL2 mRNA in the colonic mucosa of AOM-treated mice were significantly decreased by astaxanthin.	astaxanthine	143-154	interleukin 1 beta	Mus musculus	25-33
25497724-3	2014	Here, we assessed the implication of alarmins (IL-1alpha, IL-33 and HMGB1) in the lung response to silica particles and found that IL-1alpha is a master cytokine that regulates IL-1beta expression.	Silicon Dioxide	99-105	interleukin 1 beta	Mus musculus	177-185
25497724-10	2014	CONCLUSIONS: We demonstrated that in response to silica exposure, IL-1alpha is rapidly released from pre-existing stocks in alveolar macrophages and promotes subsequent lung inflammation through the stimulation of IL-1beta production.	Silicon Dioxide	49-55	interleukin 1 beta	Mus musculus	214-222
25514406-7	2014	Sodium houttuyfonate showed more potent anti-inflammatory activities than that of 2-undecanone at the same dosage, both in vitro and in vivo, although both compounds significantly inhibited the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and the expression of toll-like receptor 4 (TLR4), but increased the secretion of interleukin-10 (IL-10) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.	sodium houttuyfonate	0-20	interleukin 1 beta	Mus musculus	249-266
25500839-6	2014	Thus, F508del-CFTR mice show enhanced IL-1beta signaling in response to P. aeruginosa.	f508del	6-13	interleukin 1 beta	Mus musculus	38-46
25514406-7	2014	Sodium houttuyfonate showed more potent anti-inflammatory activities than that of 2-undecanone at the same dosage, both in vitro and in vivo, although both compounds significantly inhibited the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and the expression of toll-like receptor 4 (TLR4), but increased the secretion of interleukin-10 (IL-10) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.	sodium houttuyfonate	0-20	interleukin 1 beta	Mus musculus	268-276
25491293-8	2014	The gene expression of IL-1beta and TNF-alpha in the FK-506 and vehicle-treated groups were 47.01% and 45.56%, 85.91% and 115.83% of that in the saline-treated group in the ocular surface, while in the lacrimal glands 49.16% and 67.60%, 94.91% and 95.77% of that in the saline-treated group, respectively.	Tacrolimus	53-59	interleukin 1 beta	Mus musculus	23-31
25491293-8	2014	The gene expression of IL-1beta and TNF-alpha in the FK-506 and vehicle-treated groups were 47.01% and 45.56%, 85.91% and 115.83% of that in the saline-treated group in the ocular surface, while in the lacrimal glands 49.16% and 67.60%, 94.91% and 95.77% of that in the saline-treated group, respectively.	Sodium Chloride	145-151	interleukin 1 beta	Mus musculus	23-31
25491293-8	2014	The gene expression of IL-1beta and TNF-alpha in the FK-506 and vehicle-treated groups were 47.01% and 45.56%, 85.91% and 115.83% of that in the saline-treated group in the ocular surface, while in the lacrimal glands 49.16% and 67.60%, 94.91% and 95.77% of that in the saline-treated group, respectively.	Sodium Chloride	270-276	interleukin 1 beta	Mus musculus	23-31
25464008-9	2014	In contrast, FK506 reduced the expression of TREM-1, IL-1beta and TNFalpha in RAW264.7 macrophages stimulated with zymosan.	Tacrolimus	13-18	interleukin 1 beta	Mus musculus	53-61
25470242-5	2014	In the present study, we investigated whether NTP suppresses inflammatory signaling and cell death pathways induced by interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNFalpha) in hepatocytes.	neurotropin	46-49	interleukin 1 beta	Mus musculus	119-136
25470242-5	2014	In the present study, we investigated whether NTP suppresses inflammatory signaling and cell death pathways induced by interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNFalpha) in hepatocytes.	neurotropin	46-49	interleukin 1 beta	Mus musculus	138-146
25470242-7	2014	The expression of NF-kappaB target genes, Il6, Nos2, Cxcl1, ccl5 and Cxcl2 induced by IL-1beta and TNFalpha was suppressed after NTP treatment.	neurotropin	129-132	interleukin 1 beta	Mus musculus	86-94
25470242-9	2014	Because JNK activation contributes to hepatocyte death, we determined that NTP treatment suppressed hepatocyte death induced by IL-1beta and TNFalpha in combination with actinomycin D.	neurotropin	75-78	interleukin 1 beta	Mus musculus	128-136
25470242-10	2014	Taken together, our data demonstrate that NTP attenuates IL-1beta and TNFalpha-mediated inflammatory cytokine expression and cell death in hepatocytes through the suppression of NF-kappaB and JNK.	neurotropin	42-45	interleukin 1 beta	Mus musculus	57-65
25485716-8	2014	Mice immunized with IB010 had significantly lower post-infection tissue bacterial loads and significantly lower serum levels of the pro-inflammatory cytokines IL-1beta, TNF-alpha and IL-6 compared to control mice in a mouse model of disseminated A. baumannii infection.	ib010	20-25	interleukin 1 beta	Mus musculus	159-167
25464008-9	2014	In contrast, FK506 reduced the expression of TREM-1, IL-1beta and TNFalpha in RAW264.7 macrophages stimulated with zymosan.	Zymosan	115-122	interleukin 1 beta	Mus musculus	53-61
25367782-3	2014	Addition to NSF, previously stimulated with 4-mer HA oligosaccharides, of ADO significantly reduced NF-kB activation, TNF-alpha and IL-1beta expression.	4-mer ha oligosaccharides	44-69	interleukin 1 beta	Mus musculus	132-140
24885478-5	2014	Compared with littermate wild-type (WT) mice, TGF-beta1(wt) Tg mice had over twofold-higher levels of latent TGF-beta1 in both plasma and lung tissue, and were protected from bleomycin-induced pulmonary inflammation, such as up-regulation of IL-1beta, TNF-alpha, and macrophage chemotactic protein-1, and infiltration of CD3(+) T cells and F4/80(+) macrophages.	Bleomycin	175-184	interleukin 1 beta	Mus musculus	242-250
24842127-3	2014	The results demonstrate that Saq-NO, but not Saq, potently decreased interleukin (IL)-10, IL-6 and nitrite accumulation and increased the levels of IL-1beta and tumour necrosis factor (TNF) in supernatants of mouse and rat macrophage cultures in vitro.	saq-no	29-35	interleukin 1 beta	Mus musculus	148-156
24842127-3	2014	The results demonstrate that Saq-NO, but not Saq, potently decreased interleukin (IL)-10, IL-6 and nitrite accumulation and increased the levels of IL-1beta and tumour necrosis factor (TNF) in supernatants of mouse and rat macrophage cultures in vitro.	Saquinavir	29-32	interleukin 1 beta	Mus musculus	148-156
25367782-3	2014	Addition to NSF, previously stimulated with 4-mer HA oligosaccharides, of ADO significantly reduced NF-kB activation, TNF-alpha and IL-1beta expression.	Adenosine	74-77	interleukin 1 beta	Mus musculus	132-140
25228203-5	2014	Our data showed that CsV dose-dependently inhibited NO, iNOS, TNF-alpha and IL-1beta expressions in LPS-stimulated RAW264.7 cells.	chikusetsusaponin V	21-24	interleukin 1 beta	Mus musculus	76-84
25251587-7	2014	Macrophages with 5-aza-dC treatment had downregulated expression of genes involved in inflammation (TNF-alpha, IL-6, IL-1beta, and inducible nitric oxidase) and chemotaxis (CD62/L-selectin, chemokine [C-C motif] ligand 2/MCP-1 [CCL2/MCP-1], CCL5, CCL9, and CCL2 receptor CCR2).	Azacitidine	17-22	interleukin 1 beta	Mus musculus	117-125
24912504-5	2014	Quercetin markedly rescued lethality, improved survival time, and inhibited serum necrosis factor alpha, interleukin 1beta, and interleukin 6, and nitric oxide (NO), and increased IL-10 secretion.	Quercetin	0-9	interleukin 1 beta	Mus musculus	105-122
24854163-5	2014	When pretreated with wogonoside, the TNF-alpha, IL-6, and IL-1beta levels were significantly decreased.	wogonoside	21-31	interleukin 1 beta	Mus musculus	58-66
24844733-6	2014	The results showed that the Se-deficient mouse model was successfully replicated, and selenium deficiency exacerbated mammary gland histopathology, increased the expressions of TNF-alpha and IL-1beta, and facilitated the activation of iNOS and COX-2 in LPS-induced mouse mastitis.	Selenium	86-94	interleukin 1 beta	Mus musculus	191-199
25168307-8	2014	Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p &lt; 0.05).	1-Butanol	29-33	interleukin 1 beta	Mus musculus	113-121
25063711-9	2014	In vitro, catalpol inhibited TNF-alpha, IL-6, IL-4 and IL-1beta production and up-regulated IL-10 expression in LPS-stimulated alveolar macrophages.	catalpol	10-18	interleukin 1 beta	Mus musculus	55-63
25168307-8	2014	Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p &lt; 0.05).	1-Butanol	29-33	interleukin 1 beta	Mus musculus	181-189
25168307-8	2014	Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p &lt; 0.05).	aq	35-37	interleukin 1 beta	Mus musculus	113-121
25245808-5	2014	In addition, the secretion of interleukin-1beta (IL-1beta) and CCL-2 was enhanced significantly by ATP, in a time- and dose-dependent manner.	Adenosine Triphosphate	99-102	interleukin 1 beta	Mus musculus	30-47
25168307-8	2014	Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p &lt; 0.05).	aq	35-37	interleukin 1 beta	Mus musculus	181-189
25245808-5	2014	In addition, the secretion of interleukin-1beta (IL-1beta) and CCL-2 was enhanced significantly by ATP, in a time- and dose-dependent manner.	Adenosine Triphosphate	99-102	interleukin 1 beta	Mus musculus	49-57
25168307-8	2014	Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p &lt; 0.05).	Succinic Acid	39-41	interleukin 1 beta	Mus musculus	113-121
25168307-8	2014	Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p &lt; 0.05).	Succinic Acid	39-41	interleukin 1 beta	Mus musculus	181-189
25574463-7	2014	RESULTS: Stimulation of the RAW 264.7 cells with LPS caused an elevated production of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1beta, which was markedly inhibited by the pretreatment with SF without causing any cytotoxic effects.	sulforaphane	227-229	interleukin 1 beta	Mus musculus	149-171
25466270-9	2014	Furthermore, resveratrol treatment down-regulated HMGB1, RAGE, p-NFkappaB, p-PI3K, p-ERK1/2, COX2, TNFalpha, IL-1beta, IL-2Ralpha, IFNgamma and IL-4.	Resveratrol	13-24	interleukin 1 beta	Mus musculus	109-117
25031296-6	2014	Aliskiren and/or valsartan significantly prevented increased expression of profibrotic growth factors (TGFbeta, CTGF and PAI-1), proinflammatory cytokines (MCP-1, TNFalpha and IL-1beta), endoplasmic reticulum (ER) stress markers (CHOP and XBP-1) and lipid accumulation in the kidney of diabetic animals.	aliskiren	0-9	interleukin 1 beta	Mus musculus	176-184
24969548-7	2014	ICA also reduced pro-inflammatory cytokine expression of interleukin-1beta and tumor necrosis factor-alpha in RAW264.7 cells cultured with Ti particles.	Titanium	139-141	interleukin 1 beta	Mus musculus	57-106
24715223-7	2014	Splenocytes or colonic strips were exposed to CDDO-Im (0.5-2 muM) concomitantly with IL-23 + IL-1beta.	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	46-53	interleukin 1 beta	Mus musculus	93-101
25031296-6	2014	Aliskiren and/or valsartan significantly prevented increased expression of profibrotic growth factors (TGFbeta, CTGF and PAI-1), proinflammatory cytokines (MCP-1, TNFalpha and IL-1beta), endoplasmic reticulum (ER) stress markers (CHOP and XBP-1) and lipid accumulation in the kidney of diabetic animals.	Valsartan	17-26	interleukin 1 beta	Mus musculus	176-184
24969548-7	2014	ICA also reduced pro-inflammatory cytokine expression of interleukin-1beta and tumor necrosis factor-alpha in RAW264.7 cells cultured with Ti particles.	icariin	0-3	interleukin 1 beta	Mus musculus	57-106
24956991-6	2014	RESULTS: IL-1beta and ER stress induced by TG-augmented the formation of osteoclasts, which was significantly inhibited by PBA and was mediated with osteoclast-specific signals, including c-Fos, NFATc1, and ER stress- associated signaling pathways, such as PERK, IRE1, GRP78, and eIF2alpha.	Thapsigargin	43-45	interleukin 1 beta	Mus musculus	9-17
25365203-6	2014	Production of immunoregulatory cytokine IL-10 was significantly inhibited, while proinflammatory cytokines IL-6, IL-1beta, TNF-alpha and IL-33 were enhanced in CS-exposed BM-MDRC.	Cesium	160-162	interleukin 1 beta	Mus musculus	113-121
24956991-1	2014	OBJECTIVE: The mechanism by which IL-1beta and thapsigargin (TG)-induced endoplasmic reticulum (ER) stress modulate the receptor activator of nuclear factor kappa-B ligand (RANKL)-mediated osteoclastogenesis remains elusive.	Thapsigargin	61-63	interleukin 1 beta	Mus musculus	34-42
25310143-4	2014	Esculetin also significantly suppresses the production of inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-1beta, which was concomitant with a decrease in their expression levels.	esculetin	0-9	interleukin 1 beta	Mus musculus	124-141
25243815-4	2014	In vivo, CE administration for 16 wk significantly ameliorated renal dysfunction in type 2 diabetic db/db mice, partially due to MG trapping, which in turn inhibited AGEs formation and lowered proinflammatory cytokines, including tumor necrosis factor alpha and IL-1beta.	Pyruvaldehyde	129-131	interleukin 1 beta	Mus musculus	262-270
25281414-8	2014	The colonic expression of proinflammatory genes, including IFNgamma, TNFalpha, CXCL1, S100A8 and IL-1beta, was significantly reduced by more than 80% with rutin as assessed by RT-qPCR.	Rutin	155-160	interleukin 1 beta	Mus musculus	97-105
25270429-9	2014	Additionally, the proinflammatory cytokine interleukin-1beta was significantly up-regulated in PCP administrated mice.	Phencyclidine	95-98	interleukin 1 beta	Mus musculus	43-60
25307695-6	2014	KEY RESULTS: Dexamethasone effectively inhibited gene expression of inflammatory molecules such as interleukin (IL)-1beta and mast cell protease-1 in the colon, but did not attenuate colorectal hypersensitivity in either model.	Dexamethasone	13-26	interleukin 1 beta	Mus musculus	99-121
25369231-6	2014	The 171 up-regulated genes and 181 down-regulated genes in spiky SP-treated cells included Il1b, Spp1, Il18, Rbp4, and Il11ra1, where these genes are mainly involved in cell proliferation, differentiation, and apoptosis.	sp	65-67	interleukin 1 beta	Mus musculus	91-95
25242730-3	2014	NAHNP significantly inhibited the production of pro-inflammatory cytokines such as TNF-alpha, IL-6 and IL-1beta in lipopolysaccharide (LPS)-induced primary mouse macrophages and DC2.4 dendritic cell line.	nahnp	0-5	interleukin 1 beta	Mus musculus	103-111
25271165-8	2014	Furthermore, GPSM3-null mice have enhanced serum and peritoneal IL-1beta production following Alum-induced peritonitis.	aluminum sulfate	94-98	interleukin 1 beta	Mus musculus	64-72
25218213-3	2014	Upregulation of TNF-alpha and IL-1beta mRNA in the brain parenchyma was independent of cerebrospinal fluid leukocytosis, pneumococcal pneumolysin and H2O2, but it was potently induced by pneumococcal cell wall (PCW) fragments.	Hydrogen Peroxide	150-154	interleukin 1 beta	Mus musculus	30-38
25405768-8	2014	RESULTS: The inflammasome-associated proteins NALP3 and ASC, but not IPAF and AIM2, are required for CS-induced IL-1beta/IL-18 release, but not IL-1alpha.	Cesium	101-103	interleukin 1 beta	Mus musculus	112-120
25405768-12	2014	CONCLUSION: This data indicates a key role for the P2X7-NALP3/ASC-caspase1/11-IL-1beta/IL-18 axis in CS induced airway inflammation, highlighting this pathway as a possible therapeutic target for the treatment of COPD.	Cesium	101-103	interleukin 1 beta	Mus musculus	78-86
25405982-8	2014	Furthermore, the mice treated with EsA had a lower level of TNF-alpha, Interleukin (IL)-1beta and IL-6 in mRNA expression.	esculentoside A	35-38	interleukin 1 beta	Mus musculus	71-93
25127755-7	2014	ZnO NPs increased the mRNA levels of inflammatory cytokine IL-1beta and protein expression of several mediators, including Cox2, PGE2, MMP-9 and finally caspase 1 in macrophages.	Zinc Oxide	0-3	interleukin 1 beta	Mus musculus	59-67
25257464-6	2014	Ghrelin inhibited the inductions of C-reactive protein, tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6, mitigated the reduction of food intake and fat mass, and consequently ameliorated body weight loss in the mouse model of lung adenocarcinoma.	Ghrelin	0-7	interleukin 1 beta	Mus musculus	85-102
25390746-1	2014	A study in mice implicates a cholesterol derivative in damping down the inflammatory response mediated by interleukin-1beta and explaining, at least in part, the immunosuppressive effect of type I interferon, which is used in the treatment of multiple sclerosis.	Cholesterol	29-40	interleukin 1 beta	Mus musculus	106-123
25078426-11	2014	In addition, SR obviously reduced the secretion of tumor necrosis factor-alpha and interleukin-1beta in the calvaria of the titanium group.	Titanium	124-132	interleukin 1 beta	Mus musculus	83-100
25405767-3	2014	ER stress, oxidative stress and high glucose concentrations may also activate the NLRP3 inflammasome leading to interleukin (IL)-1beta production and caspase-1 dependent pyroptosis.	Glucose	37-44	interleukin 1 beta	Mus musculus	112-134
25131506-8	2014	Moreover, pre-treatment with curcumin attenuated LPS-induced microglial activation and overproduction of pro-inflammatory cytokine (interleukin-1beta and tumor necrosis factor-alpha), as well as the levels of inducible nitric oxide synthase and cyclooxygenase-2 mRNA in the hippocampus and prefrontal cortex (PFC).	Curcumin	29-37	interleukin 1 beta	Mus musculus	132-181
25205101-3	2014	Here, we report that ATP-mediated suppression of IFNgamma production by Th17 cells can be overcome by genetic ablation of CD73 or by using IL1beta instead of TGFbeta to program Th17 cells ex vivo.	Adenosine Triphosphate	21-24	interleukin 1 beta	Mus musculus	139-146
25038318-3	2014	The aim of the present study was to investigate the effects of niacin on the production of pro-inflammatory cytokines TNF-alpha, IL-6 and IL-1beta in LPS-induced mouse alveolar macrophages and explore its underlying mechanism.	Niacin	63-69	interleukin 1 beta	Mus musculus	138-146
25347266-7	2014	As determined from the spleen after the FST: Gly and Arg regulated the effects of IL-1beta; Gly, Pro, and Arg regulated the effects of IL-6; PE and all of the amino acids present in PE regulated the effects of TNF-alpha.	Glycine	45-48	interleukin 1 beta	Mus musculus	82-90
25347266-7	2014	As determined from the spleen after the FST: Gly and Arg regulated the effects of IL-1beta; Gly, Pro, and Arg regulated the effects of IL-6; PE and all of the amino acids present in PE regulated the effects of TNF-alpha.	Arginine	53-56	interleukin 1 beta	Mus musculus	82-90
25347266-9	2014	As determined from the serum after the TST: PE and Gly regulated the effects of TNF-alpha; Gly and Arg regulated the effects of IL-1beta; Gly, Pro, and Arg regulated the effects of IL-6; PE and all of the amino acids present in PE regulated the effects of TNF-alpha.	Glycine	91-94	interleukin 1 beta	Mus musculus	128-136
25347266-9	2014	As determined from the serum after the TST: PE and Gly regulated the effects of TNF-alpha; Gly and Arg regulated the effects of IL-1beta; Gly, Pro, and Arg regulated the effects of IL-6; PE and all of the amino acids present in PE regulated the effects of TNF-alpha.	Arginine	99-102	interleukin 1 beta	Mus musculus	128-136
25347266-9	2014	As determined from the serum after the TST: PE and Gly regulated the effects of TNF-alpha; Gly and Arg regulated the effects of IL-1beta; Gly, Pro, and Arg regulated the effects of IL-6; PE and all of the amino acids present in PE regulated the effects of TNF-alpha.	Glycine	91-94	interleukin 1 beta	Mus musculus	128-136
24756886-7	2014	RESULTS: (1) Morphine induces robust BV-2 cell activation, as evidenced by increased p38 mitogen-activated protein kinase phosphorylation, nuclear factor-kappaB translocation and mRNA expression of pro-inflammatory cytokines [including interleukin-1beta (IL-1beta), IL-6 and tumour necrosis factor-alpha], inducible nitric oxide synthase and Toll-like receptor-4, and these changes are inhibited by resveratrol.	Morphine	13-21	interleukin 1 beta	Mus musculus	236-253
24756886-7	2014	RESULTS: (1) Morphine induces robust BV-2 cell activation, as evidenced by increased p38 mitogen-activated protein kinase phosphorylation, nuclear factor-kappaB translocation and mRNA expression of pro-inflammatory cytokines [including interleukin-1beta (IL-1beta), IL-6 and tumour necrosis factor-alpha], inducible nitric oxide synthase and Toll-like receptor-4, and these changes are inhibited by resveratrol.	Morphine	13-21	interleukin 1 beta	Mus musculus	255-263
25151099-4	2014	The results showed that scoparone treatment remarkably attenuated LPS-induced pulmonary edema, histological severities, myeloperoxidase activity, and TNF-alpha, IL-6 and IL-1beta production in vivo.	scoparone	24-33	interleukin 1 beta	Mus musculus	170-178
25038318-5	2014	The results showed that niacin reduced the levels of TNF-alpha, IL-6 and IL-1beta in LPS-challenged alveolar macrophages.	Niacin	24-30	interleukin 1 beta	Mus musculus	73-81
25151099-5	2014	We also found that scoparone inhibited LPS-induced TLR4 expression, NF-kappaB activation, TNF-alpha, IL-6 and IL-1beta production in alveolar macrophages in vitro.	scoparone	19-28	interleukin 1 beta	Mus musculus	110-118
25295542-8	2014	IL-1beta cleavage and secretion were impaired in HO-1-deficient macrophages, and CO-dependent processing of IL-1beta required the presence of bacteria-derived ATP.	Adenosine Triphosphate	159-162	interleukin 1 beta	Mus musculus	108-116
25194678-5	2014	DSS-induced degradation of inhibitory kappaBalpha (IkappaBalpha) and the phosphorylation of nuclear factor-kappa B (NF-kappaB) p65 as well as the mRNA expression of pro-inflammatory mediators (inducible NO synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1), TNF-alpha, interleukin-1beta (IL-1beta) and IL-6) in the colon were also downregulated by mangiferin treatment.	Dextran Sulfate	0-3	interleukin 1 beta	Mus musculus	278-295
25194678-5	2014	DSS-induced degradation of inhibitory kappaBalpha (IkappaBalpha) and the phosphorylation of nuclear factor-kappa B (NF-kappaB) p65 as well as the mRNA expression of pro-inflammatory mediators (inducible NO synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1), TNF-alpha, interleukin-1beta (IL-1beta) and IL-6) in the colon were also downregulated by mangiferin treatment.	Dextran Sulfate	0-3	interleukin 1 beta	Mus musculus	297-305
25295542-10	2014	The ATP then bound to macrophage nucleotide P2 receptors, resulting in activation of the NALP3/IL-1beta inflammasome to amplify bacterial phagocytosis by macrophages.	Adenosine Triphosphate	4-7	interleukin 1 beta	Mus musculus	95-103
24948542-6	2014	After treatment with VPA, the renal level of malondialdehyde and the activity of myeloperoxidase decreased markedly; the activity of superoxide dismutase and the glutathione content increased accordingly; and the serum levels of tumor necrosis factor alpha, interleukin 1beta, and interleukin 6 decreased markedly.	Valproic Acid	21-24	interleukin 1 beta	Mus musculus	258-275
25261480-8	2014	Furthermore, vizantin blocked the LPS-induced release of TNF-alpha and IL-1beta and inhibited death in mice.	6,6'-bis-O-(3-nonyldodecanoyl)-alpha,alpha'-trehalose	13-21	interleukin 1 beta	Mus musculus	71-79
25195016-2	2014	This study evaluated the imaging properties of (99m)Tc-TNFR2-Fc-IL-1RA ((99m)Tc-TFI), a dual-domain cytokine radioligand that targets TNF-alpha and IL-1beta pathways, in assessing atherosclerosis development in apolipoprotein-E-deficient (ApoE(-)(/)(-)) mice.	tc-tfi	77-83	interleukin 1 beta	Mus musculus	148-156
25134730-10	2014	Administration of rosiglitazone during the full duration of MPTPp treatment reverted both TNF-alpha and IL-1beta colocalization with Iba-1 to control levels.	Rosiglitazone	18-31	interleukin 1 beta	Mus musculus	104-112
25134730-10	2014	Administration of rosiglitazone during the full duration of MPTPp treatment reverted both TNF-alpha and IL-1beta colocalization with Iba-1 to control levels.	mptpp	60-65	interleukin 1 beta	Mus musculus	104-112
25125332-5	2014	In the present study, we found trehalose inhibited generation of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, and nitric oxide in the conditioned medium released from lipopolysaccharide (LPS)-stimulated BV-2 cells.	Trehalose	31-40	interleukin 1 beta	Mus musculus	65-82
25442271-7	2014	Artesunate suppressed cigarette smoke-induced increases in BAL fluid total and differential cell counts; levels of IL-1beta, MCP-1, IP-10 and KC; and levels of oxidative biomarkers 8-isoprostane, 8-OHdG and 3-nitrotyrosine in a dose-dependent manner.	Artesunate	0-10	interleukin 1 beta	Mus musculus	115-123
25123790-2	2014	TCBQ-treatment causes significant liver injury (the elevation of serum AST and ALT activities, histopathological changes in liver section including centrilobular necrosis and inflammatory cells), oxidative stress (the elevation of TBAR level and the inhibition of SOD and catalase activities) and inflammation (up-regulation of iNOS, COX-2, IL-1beta, IL-6, TNF-alpha and NF-kappaB).	Chloranil	0-4	interleukin 1 beta	Mus musculus	341-349
25315906-11	2014	In addition, metformin activated AMPK phosphorylation, inhibited NF-kappaB activation, down-regulated cytokine (IL-1beta, IL-6, TNF-alpha) and ICAM-1 expression following tMCAO (P &lt; 0.05).	Metformin	13-22	interleukin 1 beta	Mus musculus	112-120
25213465-9	2014	Ursolic acid (20 mg/kg) also inhibited TNBS-induced IL-1beta, IL-6, TNF-alpha by 93, 86, and 85%, respectively (p &lt; 0.05).	ursolic acid	0-12	interleukin 1 beta	Mus musculus	52-60
25314304-4	2014	Our observations showed that pretreatment with PQQ significantly inhibited the production of NO and PGE2 and suppressed the expression of pro-inflammatory mediators such as iNOS, COX-2, TNF-a, IL-1b, IL-6, MCP-1 and MIP-1a in LPS treated primary microglia cells.	PQQ Cofactor	47-50	interleukin 1 beta	Mus musculus	193-198
25213465-9	2014	Ursolic acid (20 mg/kg) also inhibited TNBS-induced IL-1beta, IL-6, TNF-alpha by 93, 86, and 85%, respectively (p &lt; 0.05).	Trinitrobenzenesulfonic Acid	39-43	interleukin 1 beta	Mus musculus	52-60
25179345-3	2014	Combination multivalent presentation of the Toll-like receptor-4 ligand MPL and cytotoxic 1,2-dioleoyl-3-trmethylammonium-propane lipids induced cell death, decreased cellular proliferation, and increased serum levels of IL-1beta and tumor necrosis factor (TNF)-alpha.	1,2-dioleoyl-3-trmethylammonium-propane lipids	90-136	interleukin 1 beta	Mus musculus	221-229
25034806-6	2014	The results showed that veratric acid inhibited LPS-induced TNF-alpha, IL-6 and IL-1beta production in a dose dependent manner.	veratric acid	24-37	interleukin 1 beta	Mus musculus	80-88
24972244-8	2014	Mangiferin (10 muM) inhibited LPS-stimulated expression of TNF-alpha, IL-1beta and IL-6 by 81.0%, 89.5% and 88.3%, respectively, whereas it increased IL-10 expression by 131.8% compared to LPS-nontreated group.	mangiferin	0-10	interleukin 1 beta	Mus musculus	70-78
24907587-0	2014	Adenosine through the A2A adenosine receptor increases IL-1beta in the brain contributing to anxiety.	Adenosine	0-9	interleukin 1 beta	Mus musculus	55-63
24972244-8	2014	Mangiferin (10 muM) inhibited LPS-stimulated expression of TNF-alpha, IL-1beta and IL-6 by 81.0%, 89.5% and 88.3%, respectively, whereas it increased IL-10 expression by 131.8% compared to LPS-nontreated group.	lps	30-33	interleukin 1 beta	Mus musculus	70-78
24972244-12	2014	Furthermore, mangiferin (20mg/kg) significantly inhibited TNF-alpha by 78%, IL-1beta by 82%, and IL-6 expressions by 88% (P&lt;0.05), but induced IL-10 expression to 79% of the normal control group (P&lt;0.05).	mangiferin	13-23	interleukin 1 beta	Mus musculus	76-84
24943488-0	2014	Contribution of mast cell-derived interleukin-1beta to uric acid crystal-induced acute arthritis in mice.	Uric Acid	55-64	interleukin 1 beta	Mus musculus	34-51
25064341-11	2014	Mangiferin pretreatment also attenuated neuroinflammation by reducing the interleukin-1 beta (IL-1beta) level in hippocampus and prefrontal cortex.	mangiferin	0-10	interleukin 1 beta	Mus musculus	74-92
25064341-11	2014	Mangiferin pretreatment also attenuated neuroinflammation by reducing the interleukin-1 beta (IL-1beta) level in hippocampus and prefrontal cortex.	mangiferin	0-10	interleukin 1 beta	Mus musculus	94-102
24907587-8	2014	Thus, our results indicate that adenosine can act as an anxiogenic by activating caspase-1 and increasing IL-1beta in the brain.	Adenosine	32-41	interleukin 1 beta	Mus musculus	106-114
25046000-3	2014	Because IL-1beta plays a central role as an initiator cytokine in immune responses, we compared doxorubicin, a drug known to induce IL-1beta production, with ten other commonly prescribed chemotherapeutic drugs in their ability to lead to processing and secretion of IL-1beta by primary mouse macrophages.	Doxorubicin	96-107	interleukin 1 beta	Mus musculus	8-16
25046000-3	2014	Because IL-1beta plays a central role as an initiator cytokine in immune responses, we compared doxorubicin, a drug known to induce IL-1beta production, with ten other commonly prescribed chemotherapeutic drugs in their ability to lead to processing and secretion of IL-1beta by primary mouse macrophages.	Doxorubicin	96-107	interleukin 1 beta	Mus musculus	132-140
24743918-6	2014	The present results showed that kaempferol markedly reduced infiltration of neutrophilic granulocyte, activation of myeloperoxidase (MPO), expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) in a dose-dependent manner, which were increased in LPS-induced mouse mastitis.	kaempferol	32-42	interleukin 1 beta	Mus musculus	220-237
25046000-3	2014	Because IL-1beta plays a central role as an initiator cytokine in immune responses, we compared doxorubicin, a drug known to induce IL-1beta production, with ten other commonly prescribed chemotherapeutic drugs in their ability to lead to processing and secretion of IL-1beta by primary mouse macrophages.	Doxorubicin	96-107	interleukin 1 beta	Mus musculus	132-140
24771071-4	2014	Using intraductal injection of LPS as a mouse model of mastitis, we found that geniposide significantly reduced the infiltration of inflammatory cells and downregulated the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6).	geniposide	79-89	interleukin 1 beta	Mus musculus	228-245
24771071-4	2014	Using intraductal injection of LPS as a mouse model of mastitis, we found that geniposide significantly reduced the infiltration of inflammatory cells and downregulated the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6).	geniposide	79-89	interleukin 1 beta	Mus musculus	247-255
25305342-7	2014	Intravenous injection of ligustilide prevented LPS-induced mechanical allodynia, and decreased LPS-induced TNF-alpha, IL-1beta, and IL-6 up-regulation in the spinal cord.	ligustilide	25-36	interleukin 1 beta	Mus musculus	118-126
25305342-9	2014	The same treatment of ligustilide also inhibited CFA-induced TNF-alpha, IL-1beta, and IL-6 up-regulation and microglial activation in the spinal cord.	ligustilide	22-33	interleukin 1 beta	Mus musculus	72-80
24803298-5	2014	In the carrageenan-induced peritonitis model, GBP significantly decreased total and differential leukocyte counts and reduced the levels of MPO activity in the plantar tissue and IL-1beta and TNF-alpha concentrations in the peritoneal exudate.	Carrageenan	7-18	interleukin 1 beta	Mus musculus	179-187
24771071-6	2014	The results of enzyme-linked immunosorbent assay (ELISA) and quantitative real-time polymerase chain reaction (qRT-PCR) showed that geniposide inhibited the expression of TNF-alpha, IL-1beta, and IL-6 in a dose-dependent manner.	geniposide	132-142	interleukin 1 beta	Mus musculus	182-190
24743918-6	2014	The present results showed that kaempferol markedly reduced infiltration of neutrophilic granulocyte, activation of myeloperoxidase (MPO), expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) in a dose-dependent manner, which were increased in LPS-induced mouse mastitis.	kaempferol	32-42	interleukin 1 beta	Mus musculus	239-247
24839088-7	2014	The results showed that PA inhibited the LPS-induced TNF-alpha, IL-6, and IL-1beta production in a dose manner.	patchouli alcohol	24-26	interleukin 1 beta	Mus musculus	74-82
24744434-4	2014	Immediately at the end of chronic Delta(9)-THC, a decrease of proinflammatory cytokines IL- 1beta and TNF-alpha and an increase of anti-inflammatory cytokine IL-10 production by macrophages were present as protein and mRNA in adolescent and adult mice.	Dronabinol	34-46	interleukin 1 beta	Mus musculus	88-97
24803295-11	2014	Preemptive administration of dexmedetomidine significantly attenuated the cytokine response after lipopolysaccharide (LPS) induced endotoxemia (TNF-alpha, IL-1beta, IL-6, P&lt;0.01, respectively).	Dexmedetomidine	29-44	interleukin 1 beta	Mus musculus	155-163
25091392-5	2014	IL-1beta promoted hyperpolarization of the resting membrane potential (Vrest), decrease of input resistance (Rin), decrease of Ih rectification, decrease in action potential (AP) threshold and decrease in the number of APs in low threshold calcium spike (LTS) bursts, while IL-6 promoted decrease of Rin and decrease in the number of APs in LTS bursts.	Calcium	240-247	interleukin 1 beta	Mus musculus	0-8
25077524-7	2014	AnxA1(+/+) mice treated with NaHS (100 mumol/kg) displayed inhibition of IL-1beta-induced leukocyte adhesion/emigration in the inflamed microcirculation, not observed in AnxA1(-/-) animals.	sodium bisulfide	29-33	interleukin 1 beta	Mus musculus	73-81
25051048-13	2014	Data from the present study demonstrated that naloxone reduced the expression levels of NF-kappaB and its upstream protein caspase-3, and reduced the LPS-induced production of nitric oxide, inducible nitric oxide synthase, tumor necrosis factor alpha, interleukin-1beta and interleukin-6 in BV2 microglia.	Naloxone	46-54	interleukin 1 beta	Mus musculus	252-269
25059110-6	2014	Immunohistochemistry and western blot results showed elevated expression of inflammatory markers such as MDA, TNF-alpha, IL-1beta, COX-2 and iNOS in hepatocytes of EtOH group.	Ethanol	164-168	interleukin 1 beta	Mus musculus	121-129
24839932-5	2014	The mRNA expression of proinflammatory cytokines, such as interleukin-1 beta (IL-1beta) and interferon-gamma (IFN-gamma), was significantly attenuated in the dorsal skin of the HMEE-fed mouse group compared with the PCL-treated mouse group.	Picryl Chloride	216-219	interleukin 1 beta	Mus musculus	58-76
24839932-5	2014	The mRNA expression of proinflammatory cytokines, such as interleukin-1 beta (IL-1beta) and interferon-gamma (IFN-gamma), was significantly attenuated in the dorsal skin of the HMEE-fed mouse group compared with the PCL-treated mouse group.	Picryl Chloride	216-219	interleukin 1 beta	Mus musculus	78-86
24839932-6	2014	In addition, in concanavalin A-stimulated and lipopolysaccharide-stimulated mouse splenocytes and macrophages, levels of IL-1beta and IFN-gamma production were attenuated following the addition of HMEE.	hmee	197-201	interleukin 1 beta	Mus musculus	121-129
25612451-9	2014	The glycyrrhizin acid significantly inhibited IL-1beta, IL-3, IL-5, IL-6, IL-10, IL-12 (p40), IL-12 (p70), IL-13, Eotaxin and TNF-alpha secreted by LPS-stimulated RAW264.7 cells (P &lt; 0.05).	glycyrrhizin acid	4-21	interleukin 1 beta	Mus musculus	46-54
25270203-1	2014	OBJECTIVE: To investigate the regulatory effects of polyporus polysaccharide (PPS) on mRNA expressions of interleukin 1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), inducible nitric oxide synthase (iNOS), transforming growth factor beta (TGF-beta) and IL-10 in M1 macrophages.	polyporus polysaccharide	52-76	interleukin 1 beta	Mus musculus	106-123
25270203-1	2014	OBJECTIVE: To investigate the regulatory effects of polyporus polysaccharide (PPS) on mRNA expressions of interleukin 1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), inducible nitric oxide synthase (iNOS), transforming growth factor beta (TGF-beta) and IL-10 in M1 macrophages.	pps	78-81	interleukin 1 beta	Mus musculus	106-123
25270203-1	2014	OBJECTIVE: To investigate the regulatory effects of polyporus polysaccharide (PPS) on mRNA expressions of interleukin 1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), inducible nitric oxide synthase (iNOS), transforming growth factor beta (TGF-beta) and IL-10 in M1 macrophages.	pps	78-81	interleukin 1 beta	Mus musculus	125-133
25270203-7	2014	The mRNA levels of IL-1beta, iNOS, IL-10, TGF-beta and TNF-alpha were raised by 100 mug/mL PPS at 3, 6, 9, 12 and 24 hours (P&lt;0.01).	pps	91-94	interleukin 1 beta	Mus musculus	19-27
25270203-10	2014	In addition, PPS can promote the mRNA expressions of IL-1beta, iNOS, IL-10, TGF-beta and TNF-alpha in M1 macrophages.	pps	13-16	interleukin 1 beta	Mus musculus	53-61
25152324-7	2014	Glyburide administration in ob/ob mice with cerulein-induced SAP also resulted in significantly reduced serum levels of interleukin 6, lipase, and amylase and led to lower production of lipopolysaccharide-stimulated interleukin 1beta release in cultured peritoneal cells, compared with vehicle-treated ob/ob mice with SAP.	Glyburide	0-9	interleukin 1 beta	Mus musculus	216-233
25152324-7	2014	Glyburide administration in ob/ob mice with cerulein-induced SAP also resulted in significantly reduced serum levels of interleukin 6, lipase, and amylase and led to lower production of lipopolysaccharide-stimulated interleukin 1beta release in cultured peritoneal cells, compared with vehicle-treated ob/ob mice with SAP.	Ceruletide	44-52	interleukin 1 beta	Mus musculus	216-233
25138219-4	2014	In cultured podocytes, size exclusion chromatography and confocal microscopy showed that inhibition of TXNIP by siRNA or verapamil prevented Hcys-induced TXNIP protein recruitment to form NLRP3 inflammasomes and abolished Hcys-induced increases in caspase-1 activity and IL-1beta production.	Verapamil	121-130	interleukin 1 beta	Mus musculus	271-279
25268699-8	2014	Doxycycline also significantly inhibited VEGF-C-induced HDLEC proliferation in vitro by modulating the PI3K/Akt/endothelial nitric oxide (NO) synthase (eNOS) pathway and significantly suppressed interleukin-1beta (IL-1beta), TNF-alpha and VEGF-C production in the RAW264.7 cell line by modulating the PI3K/Akt/nuclear factor-kappaB (NF-kappaB) pathway.	Doxycycline	0-11	interleukin 1 beta	Mus musculus	195-212
25268699-8	2014	Doxycycline also significantly inhibited VEGF-C-induced HDLEC proliferation in vitro by modulating the PI3K/Akt/endothelial nitric oxide (NO) synthase (eNOS) pathway and significantly suppressed interleukin-1beta (IL-1beta), TNF-alpha and VEGF-C production in the RAW264.7 cell line by modulating the PI3K/Akt/nuclear factor-kappaB (NF-kappaB) pathway.	Doxycycline	0-11	interleukin 1 beta	Mus musculus	214-222
25138219-4	2014	In cultured podocytes, size exclusion chromatography and confocal microscopy showed that inhibition of TXNIP by siRNA or verapamil prevented Hcys-induced TXNIP protein recruitment to form NLRP3 inflammasomes and abolished Hcys-induced increases in caspase-1 activity and IL-1beta production.	Homocysteine	141-145	interleukin 1 beta	Mus musculus	271-279
25172655-6	2014	Our results show that alcohol induces transcription of miR 339-5p, IL-6, IL-1beta and TNF-alpha in mouse brain tissue and isolated microglial cells by activating NF-kappaB.	Alcohols	22-29	interleukin 1 beta	Mus musculus	73-81
25222049-8	2014	Bazhen decoction administration significantly decrease acetaminophen-induced serum ALT, AST, ALP, LDH, TNF-alpha, IL-1beta, ROS, TBARS and protein carbonyl group levels, as well as GSH depletion and loss of MMP.	Acetaminophen	55-68	interleukin 1 beta	Mus musculus	114-122
25162585-3	2014	Results show that 6-DG significantly attenuated inducible nitric oxide synthase (iNOS, NOS2), cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in the LPS-mediated murine macrophages (RAW 264.7 cells).	6-dehydrogingerdione	18-22	interleukin 1 beta	Mus musculus	120-137
25162585-3	2014	Results show that 6-DG significantly attenuated inducible nitric oxide synthase (iNOS, NOS2), cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in the LPS-mediated murine macrophages (RAW 264.7 cells).	6-dehydrogingerdione	18-22	interleukin 1 beta	Mus musculus	139-147
25162585-5	2014	Moreover, 6-DG increased the ratio of phosphorylated signal transducers and activators of transcription 1 (p-STAT1)/p-STAT3 and down-regulated the gene expression of IL-1beta, IL-6, and IL-10.	6-dehydrogingerdione	10-14	interleukin 1 beta	Mus musculus	166-174
24905858-8	2014	Tropisetron decreased the expression of inflammatory molecules including tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and iNOS and improved histopathological damage and renal dysfunction.	Tropisetron	0-11	interleukin 1 beta	Mus musculus	114-132
25216247-9	2014	Moreover, Al2O3 nanoparticles, but not carbon black NPs, increased IL-1beta but decreased OPN and IL-6 in THP-1 and PBMC.	Aluminum Oxide	10-15	interleukin 1 beta	Mus musculus	67-75
25216251-6	2014	Conversely, treatment of primary mouse hepatocytes with IL-1beta significantly increased triglyceride accumulation and Fatty acid synthase expression.	Triglycerides	89-101	interleukin 1 beta	Mus musculus	56-64
24905858-8	2014	Tropisetron decreased the expression of inflammatory molecules including tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and iNOS and improved histopathological damage and renal dysfunction.	Tropisetron	0-11	interleukin 1 beta	Mus musculus	134-142
24995576-5	2014	The administration of MPTP (30 mg/kg for four successive days) significantly induced motor impairments as determined by behavioral studies (narrow beam test, catalepsy and akinesia), lowered dopamine levels and up-regulated the expressions of the inflammatory and apoptotic markers (tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, inducible nitric oxide synthase, glial fibrillary acidic protein, cyclooxygenase-2 and Bax).	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	22-26	interleukin 1 beta	Mus musculus	312-329
25189223-12	2014	RT-PCR showed that mRNA levels for IL-1beta were increased in lumbar spinal cord of cisplatin-treated groups pretreated with either saline, NaHCO3 or resveratrol/cisplatin-treated groups.	Cisplatin	84-93	interleukin 1 beta	Mus musculus	35-43
24952332-4	2014	Our results showed that FLX could attenuate lipopolysaccharide (LPS)-induced production of interleukin-1beta (IL-1beta), the expression of the indoleamine 2,3 dioxygenase (IDO) enzyme and the depletion of 5-HT.	Fluoxetine	24-27	interleukin 1 beta	Mus musculus	91-108
24952332-4	2014	Our results showed that FLX could attenuate lipopolysaccharide (LPS)-induced production of interleukin-1beta (IL-1beta), the expression of the indoleamine 2,3 dioxygenase (IDO) enzyme and the depletion of 5-HT.	Fluoxetine	24-27	interleukin 1 beta	Mus musculus	110-118
25189223-12	2014	RT-PCR showed that mRNA levels for IL-1beta were increased in lumbar spinal cord of cisplatin-treated groups pretreated with either saline, NaHCO3 or resveratrol/cisplatin-treated groups.	Sodium Chloride	132-138	interleukin 1 beta	Mus musculus	35-43
25189223-12	2014	RT-PCR showed that mRNA levels for IL-1beta were increased in lumbar spinal cord of cisplatin-treated groups pretreated with either saline, NaHCO3 or resveratrol/cisplatin-treated groups.	Sodium Bicarbonate	140-146	interleukin 1 beta	Mus musculus	35-43
25189223-12	2014	RT-PCR showed that mRNA levels for IL-1beta were increased in lumbar spinal cord of cisplatin-treated groups pretreated with either saline, NaHCO3 or resveratrol/cisplatin-treated groups.	Resveratrol	150-161	interleukin 1 beta	Mus musculus	35-43
25189223-12	2014	RT-PCR showed that mRNA levels for IL-1beta were increased in lumbar spinal cord of cisplatin-treated groups pretreated with either saline, NaHCO3 or resveratrol/cisplatin-treated groups.	Cisplatin	162-171	interleukin 1 beta	Mus musculus	35-43
25087995-9	2014	RESULTS: UA treatment significantly reduced the incidence and severity of CIA-induced arthritis, accompanied by decreased expression of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6, IL-21 and IL-17) and oxidative stress markers (nitrotyrosine and iNOS) in arthritic joints.	ursolic acid	9-11	interleukin 1 beta	Mus musculus	174-182
25179214-8	2014	TNB instillations in IL-1R null mice demonstrated the critical role of IL-1beta in initiation of TNB-induced lung inflammation.	1,3,5-TRINITROBENZENE	0-3	interleukin 1 beta	Mus musculus	71-79
25179214-8	2014	TNB instillations in IL-1R null mice demonstrated the critical role of IL-1beta in initiation of TNB-induced lung inflammation.	1,3,5-TRINITROBENZENE	97-100	interleukin 1 beta	Mus musculus	71-79
24661197-1	2014	Silica crystals (silica), which are the main mineral component of volcanic ash and desert dust, can activate the caspase-1-activating inflammasome in phagocytic cells to secrete IL-1beta.	Silicon Dioxide	0-6	interleukin 1 beta	Mus musculus	178-186
24661197-1	2014	Silica crystals (silica), which are the main mineral component of volcanic ash and desert dust, can activate the caspase-1-activating inflammasome in phagocytic cells to secrete IL-1beta.	Silicon Dioxide	17-23	interleukin 1 beta	Mus musculus	178-186
24559509-7	2014	A significant decrease in the levels of IL-1beta, -17, and IP-10 were observed in the 0.2% EFAs mixture-treated group, compared with the other groups.	Fatty Acids, Essential	91-95	interleukin 1 beta	Mus musculus	40-48
24859008-3	2014	In this study, we found that IL-6 production is selectively inhibited by the BET bromodomain protein (BRD) inhibitor I-BET151 in RAW264.7 cells stimulated with lipopolysaccharide (LPS), whereas I-BET151 did not alter the production of several other cytokines (TNFalpha, IL-1beta and IL-10) at the concentration of IBET151 used.	GSK1210151A	117-125	interleukin 1 beta	Mus musculus	270-278
24889889-9	2014	In addition, the levels of IL-1beta and TNF-alpha were suppressed significantly by treatment with a medium and high dose of LC-01.	lc-01	124-129	interleukin 1 beta	Mus musculus	27-35
25113933-0	2014	Oleanolic acid analogs as NO, TNF-alpha and IL-1beta inhibitors: synthesis, biological evaluation and docking studies.	Oleanolic Acid	0-14	interleukin 1 beta	Mus musculus	44-52
24798499-8	2014	Moreover, BA prevented APAP-induced inflammasome signaling as determined by interleukin (IL)-1beta, IL-18, and caspase-1 cleavage in liver tissues.	Benzyl Alcohol	10-12	interleukin 1 beta	Mus musculus	76-98
25004092-4	2014	We find that the proinflammatory cytokine combination IL-1beta+IFNgamma, induces: a) ER stress, mSREBP-1, and iPLA2beta, b) lysophosphatidylcholine (LPC) generation, c) neutral sphingomyelinase-2 (NSMase2), d) ceramide accumulation, e) mitochondrial membrane decompensation, f) caspase-3 activation, and g) beta-cell apoptosis.	Lysophosphatidylcholines	124-147	interleukin 1 beta	Mus musculus	54-62
25004092-4	2014	We find that the proinflammatory cytokine combination IL-1beta+IFNgamma, induces: a) ER stress, mSREBP-1, and iPLA2beta, b) lysophosphatidylcholine (LPC) generation, c) neutral sphingomyelinase-2 (NSMase2), d) ceramide accumulation, e) mitochondrial membrane decompensation, f) caspase-3 activation, and g) beta-cell apoptosis.	Ceramides	210-218	interleukin 1 beta	Mus musculus	54-62
24798499-8	2014	Moreover, BA prevented APAP-induced inflammasome signaling as determined by interleukin (IL)-1beta, IL-18, and caspase-1 cleavage in liver tissues.	Acetaminophen	23-27	interleukin 1 beta	Mus musculus	76-98
24752390-5	2014	The results showed that KHG26377 reduced the production of prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), reactive oxygen species (ROS), and nitric oxide (NO) in LPS-activated microglia.	2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride	24-32	interleukin 1 beta	Mus musculus	125-142
24975837-1	2014	Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the acute tubular necrosis score and up-regulate cytokines (e.g., IL-1beta and TNF-alpha).	Cisplatin	0-9	interleukin 1 beta	Mus musculus	284-292
24975832-5	2014	KHG26693 suppressed several inflammatory responses in LPS-activated cells, as evidenced by decreased levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), hydrogen peroxide (H(2)O(2)), reactive oxygen species (ROS), nitric oxide (NO), and lipid peroxidation.	N-adamantyl-4-methylthiazol-2-amine	0-8	interleukin 1 beta	Mus musculus	152-169
24752390-5	2014	The results showed that KHG26377 reduced the production of prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), reactive oxygen species (ROS), and nitric oxide (NO) in LPS-activated microglia.	2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride	24-32	interleukin 1 beta	Mus musculus	144-152
24780381-5	2014	In addition, maternal ethanol induced up-regulation of toll-like receptor 4 (TLR4), and the down-streaming myeloid differentiation factor 88 (MyD88), NF-kappaB, TNF-alpha, and IL-1beta in embryos, and this was inhibited by astaxanthin pretreatment.	Ethanol	22-29	interleukin 1 beta	Mus musculus	176-184
24621884-7	2014	Furthermore, Ipt negatively regulated nod-like receptor protein 3 (NLRP3) expression and, in turn, inhibited microglia-mediated neuro-inflammation by suppressing the activation of NLRP3-inflammasome/caspase-1/interleukin 1beta axis in the hippocampus of CMS mice.	N-(1-methylethyl)-1,1,2-trimethylpropylamine	13-16	interleukin 1 beta	Mus musculus	209-226
24946862-6	2014	However, cinnamon metabolite NaB abrogated IL-1beta-induced loss of these proteins.	nab	29-32	interleukin 1 beta	Mus musculus	43-51
24946862-8	2014	Furthermore, suppression of IL-1beta-induced expression of iNOS in astrocytes by NaB and reversal of NaB-mediated protection of Parkin/DJ-1 by DETA-NONOate in astrocytes indicate that NaB protects Parkin/DJ-1 in activated astrocytes via suppressing iNOS.	nab	81-84	interleukin 1 beta	Mus musculus	28-36
25272939-0	2014	Losartan inhibits LPS + ATP-induced IL-1beta secretion from mouse primary macrophages by suppressing NALP3 inflammasome.	Losartan	0-8	interleukin 1 beta	Mus musculus	36-44
25272939-0	2014	Losartan inhibits LPS + ATP-induced IL-1beta secretion from mouse primary macrophages by suppressing NALP3 inflammasome.	Adenosine Triphosphate	24-27	interleukin 1 beta	Mus musculus	36-44
25272939-3	2014	In this study, we attempted to clarify whether losartan has an inhibitory effect on IL-1beta.	Losartan	47-55	interleukin 1 beta	Mus musculus	84-92
25272939-4	2014	To further elucidate the molecular mechanism underlying the anti-IL-1beta property of losartan, we studied the LPS+ATP-induced activation of NALP3 inflammasome which controls the muturation and secretion of IL-1beta.	Losartan	86-94	interleukin 1 beta	Mus musculus	65-73
25272939-4	2014	To further elucidate the molecular mechanism underlying the anti-IL-1beta property of losartan, we studied the LPS+ATP-induced activation of NALP3 inflammasome which controls the muturation and secretion of IL-1beta.	Losartan	86-94	interleukin 1 beta	Mus musculus	207-215
25272939-4	2014	To further elucidate the molecular mechanism underlying the anti-IL-1beta property of losartan, we studied the LPS+ATP-induced activation of NALP3 inflammasome which controls the muturation and secretion of IL-1beta.	Adenosine Triphosphate	115-118	interleukin 1 beta	Mus musculus	207-215
25272939-5	2014	METHODS: LPS and ATP were used to stimulate the release of IL-1beta from thioglycollate-elicited macrophages from BALB/c mice.	Adenosine Triphosphate	17-20	interleukin 1 beta	Mus musculus	59-67
25272939-5	2014	METHODS: LPS and ATP were used to stimulate the release of IL-1beta from thioglycollate-elicited macrophages from BALB/c mice.	Thioglycolates	73-87	interleukin 1 beta	Mus musculus	59-67
25272939-7	2014	RESULTS: In cultured thioglycollate-elicited macrophages, we observed that LPS + ATP greatly enhanced IL-1 beta secretion (6938.00 +/- 83.45; P &lt; 0.05) and the mRNA levels of NALP3, caspase-1 which are two main components of NALP3 inflammasome (60.88 +/- 8.28; 1.31 +/- 0.04, P &lt; 0.05 for both).	Thioglycolates	21-35	interleukin 1 beta	Mus musculus	102-111
25272939-7	2014	RESULTS: In cultured thioglycollate-elicited macrophages, we observed that LPS + ATP greatly enhanced IL-1 beta secretion (6938.00 +/- 83.45; P &lt; 0.05) and the mRNA levels of NALP3, caspase-1 which are two main components of NALP3 inflammasome (60.88 +/- 8.28; 1.31 +/- 0.04, P &lt; 0.05 for both).	Adenosine Triphosphate	81-84	interleukin 1 beta	Mus musculus	102-111
25272939-8	2014	The macrophages co-cultured with losartan showed low production of IL-1beta (3907.50 +/- 143.61; P &lt; 0.05) and low production of NALP3, caspase-1mRNA (29.82 +/- 6.92; 1.12 +/- 0.05, P &lt; 0.05 for both).	Losartan	33-41	interleukin 1 beta	Mus musculus	67-75
25272939-11	2014	Losartan is able to suppress the LPS + ATP-induced production of IL-1beta protein.	Losartan	0-8	interleukin 1 beta	Mus musculus	65-73
25272939-11	2014	Losartan is able to suppress the LPS + ATP-induced production of IL-1beta protein.	Adenosine Triphosphate	39-42	interleukin 1 beta	Mus musculus	65-73
24474144-5	2014	A subsequent short-term experiment revealed that dietary GOFA-L-NAME decreased the mRNA expression of inflammatory enzymes, such as iNOS and COX-2, and proinflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and macrophage inflammatory protein (MIP)-2 in the colonic mucosa of mice that received 1.5% DSS in their drinking water for 7 days.	4'-geranyloxyferulic acid	57-61	interleukin 1 beta	Mus musculus	216-238
25146993-11	2014	The expression of IL-1beta and VEGF-A was significantly reduced in the right TG with dexamethasone treatment.	Dexamethasone	85-98	interleukin 1 beta	Mus musculus	18-26
24944202-8	2014	The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors.	Colforsin	40-49	interleukin 1 beta	Mus musculus	15-23
24944202-8	2014	The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors.	Cyclic AMP	61-65	interleukin 1 beta	Mus musculus	15-23
24944202-8	2014	The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	197-202	interleukin 1 beta	Mus musculus	15-23
24944202-8	2014	The effects of IL-1beta or TNF-alpha on forskolin-stimulated cAMP formation and smooth muscle relaxation reflected inhibition of AC5/6 activity and activation of PDE4D5 and were partly reversed by 1400W or PD98059 and completely reversed by a combination of the two inhibitors.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	206-213	interleukin 1 beta	Mus musculus	15-23
25146101-5	2014	The results showed that GdCl3 had no macrophage depletion effect in colonic mucosa, but significantly suppressed TNBS and DSS-induced TNFalpha, IL-1beta and IL-6 secretions.	gadolinium chloride	24-29	interleukin 1 beta	Mus musculus	144-152
25146101-5	2014	The results showed that GdCl3 had no macrophage depletion effect in colonic mucosa, but significantly suppressed TNBS and DSS-induced TNFalpha, IL-1beta and IL-6 secretions.	Trinitrobenzenesulfonic Acid	113-117	interleukin 1 beta	Mus musculus	144-152
25146101-5	2014	The results showed that GdCl3 had no macrophage depletion effect in colonic mucosa, but significantly suppressed TNBS and DSS-induced TNFalpha, IL-1beta and IL-6 secretions.	dss	122-125	interleukin 1 beta	Mus musculus	144-152
24474144-5	2014	A subsequent short-term experiment revealed that dietary GOFA-L-NAME decreased the mRNA expression of inflammatory enzymes, such as iNOS and COX-2, and proinflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and macrophage inflammatory protein (MIP)-2 in the colonic mucosa of mice that received 1.5% DSS in their drinking water for 7 days.	NG-Nitroarginine Methyl Ester	62-68	interleukin 1 beta	Mus musculus	216-238
24933511-3	2014	By diminishing IL-1beta induced apoptotic and oxidative stress, chondrocyte protection and proliferation was up-regulated with C-CP-Fe-bLf-NCs as compared to void and C-CP-Apo(metal free)-bLf-NCs.	c-cp	127-131	interleukin 1 beta	Mus musculus	15-23
24936064-8	2014	Although both IL-1beta- and TNFalpha-treated myocytes showed significant increase in reactive oxidative species (ROS), Western blot experiments revealed that only IL-1beta increased PKCepsilon membrane translocation.	ros	113-116	interleukin 1 beta	Mus musculus	14-22
25101848-7	2014	significantly reduced mRNA expressions of inflammatory cytokines, TNF-alpha, IL-6, IL-1beta, in carrageenan-injected mice.	Carrageenan	96-107	interleukin 1 beta	Mus musculus	83-91
24993070-5	2014	Inhaled budesonide, the classic therapeutic drug for chronic asthma, could inhibit asthma-induced microglial activation, down-regulate TNFalpha and IL-1beta but up-regulate TGFbeta and IL-10 of mouse brain, and thereby attenuate neuronal loss.	Budesonide	8-18	interleukin 1 beta	Mus musculus	148-156
25115855-9	2014	After TET pretreatment, the levels of IL1beta and TNFalpha (both in transcription and translation) were significantly inhibited in a dose-dependent manner.	tetrandrine	6-9	interleukin 1 beta	Mus musculus	38-45
25115855-11	2014	CONCLUSIONS: Our results indicate that TET can effectively suppress microglial activation and inhibit the production of IL1beta and TNFalpha by regulating the NF-kB and ERK signaling pathways.	tetrandrine	39-42	interleukin 1 beta	Mus musculus	120-127
25104388-4	2014	25-HC acts by antagonizing sterol response element-binding protein (SREBP) processing to reduce Il1b transcription and to broadly repress IL-1-activating inflammasomes.	Sterols	27-33	interleukin 1 beta	Mus musculus	96-100
24933511-3	2014	By diminishing IL-1beta induced apoptotic and oxidative stress, chondrocyte protection and proliferation was up-regulated with C-CP-Fe-bLf-NCs as compared to void and C-CP-Apo(metal free)-bLf-NCs.	Metals	176-181	interleukin 1 beta	Mus musculus	15-23
24836981-5	2014	We determined the role of ROS generation in mediating increases in IL-1beta secretion through caspase-1 activation caused by NLRP3 inflammasome activation in an environment-induced murine dry eye (DE) model.	Reactive Oxygen Species	26-29	interleukin 1 beta	Mus musculus	67-75
24357461-9	2014	In cultured macrophages, combinatorial treatment with high glucose and palmitate amplifies MRP8 expression in a Tlr4-dependent manner, and recombinant MRP8 protein markedly increases gene expression of the inflammatory cytokines interleukin-1beta and tumor necrosis factor alpha.	Glucose	59-66	interleukin 1 beta	Mus musculus	229-278
24840346-3	2014	The inhibition of serine protease activity with inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride hydrochloride significantly diminished enhanced production of proinflammatory interferon-gamma, IL-1beta, IL-1alpha, and Granzyme A activity even in the presence of a Th1-inducing cytokine, IL-12 from splenocytes from in vivo estrogen-treated mice.	4-(2-aminoethyl)benzenesulfonylfluoride	58-113	interleukin 1 beta	Mus musculus	196-204
24681250-2	2014	The signaling pathway by which IL-1beta exerts this function involves the blood-brain-barrier and induced central prostaglandin synthesis, but the identity of the blood-brain-barrier cells responsible for this signal transduction has been unclear, with both endothelial cells and perivascular macrophages suggested as critical components.	Prostaglandins	114-127	interleukin 1 beta	Mus musculus	31-39
24681250-4	2014	Following both intraperitoneal and intravenous administration of IL-1beta, mice lacking IL-1R1 in hematopoietic cells showed induced expression of the activity marker c-Fos in the paraventricular hypothalamic nucleus, and increased plasma levels of ACTH and corticosterone.	Corticosterone	258-272	interleukin 1 beta	Mus musculus	65-73
24836981-17	2014	These results prompt us to suggest that the ROS-NLRP3-IL-1beta signaling pathway might play a priming role in environment-induced DE progression.	Reactive Oxygen Species	44-47	interleukin 1 beta	Mus musculus	54-62
24836981-7	2014	Increases in ROS production preceded rises in corneal and conjunctival gene expression of NLRP3 inflammasome components and IL-1beta that were identified using real-time PCR.	Reactive Oxygen Species	13-16	interleukin 1 beta	Mus musculus	124-132
24836981-10	2014	Rises in ROS generation occurred after 1 week of ICES exposure, which preceded increases in gene expression of three NLRP3 inflammasome components (i.e. NLRP3, ASC and caspase-1) leading to rises in bioactive IL-1beta release.	Reactive Oxygen Species	9-12	interleukin 1 beta	Mus musculus	209-217
24836981-14	2014	NAC also down-regulated both increases in NLRP3, ASC, caspase-1 and IL-1beta mRNA levels, along with their immunostaining.	Acetylcysteine	0-3	interleukin 1 beta	Mus musculus	68-76
24836981-16	2014	We show in a dessicating DE disease murine model that rises in ROS generation trigger NLRP3 inflammasome complexation and activation leading to increases in bioactive IL-1beta secretion.	Reactive Oxygen Species	63-66	interleukin 1 beta	Mus musculus	167-175
25136295-4	2014	Here we show that chronic ethanol treatment increases the co-localization of caspase-1 with GFAP(+) cells, and up-regulates IL-1beta and IL-18 in the frontal medial cortex in WT, but not in TLR4 knockout mice.	Ethanol	26-33	interleukin 1 beta	Mus musculus	124-132
24873723-1	2014	Bacterial lipopolysaccharide (LPS) stimulation of macrophages and inflammation via the Toll-like receptor 4 (TLR4) signaling pathway through NF-kappaBeta generates reactive oxygen species (ROS) and proinflammatory cytokines such as IL-1beta, IL-6, and TNFalpha.	Reactive Oxygen Species	164-187	interleukin 1 beta	Mus musculus	232-240
24873723-1	2014	Bacterial lipopolysaccharide (LPS) stimulation of macrophages and inflammation via the Toll-like receptor 4 (TLR4) signaling pathway through NF-kappaBeta generates reactive oxygen species (ROS) and proinflammatory cytokines such as IL-1beta, IL-6, and TNFalpha.	Reactive Oxygen Species	189-192	interleukin 1 beta	Mus musculus	232-240
25136295-6	2014	Ethanol, as ATP and LPS treatments, up-regulates NLRP3 expression, and causes caspase-1 cleavage and the release of IL-1beta and IL-18 in astrocytes supernatant.	Ethanol	0-7	interleukin 1 beta	Mus musculus	116-124
25136295-7	2014	Ethanol-induced NLRP3/caspase-1 activation is mediated by mitochondrial (m) reactive oxygen species (ROS) generation because when using a specific mitochondria ROS scavenger, the mito-TEMPO (500 muM) or NLRP3 blocking peptide (4 mug/ml) or a specific caspase-1 inhibitor, Z-YVAD-FMK (10 muM), abrogates mROS release and reduces the up-regulation of IL-1beta and IL-18 induced by ethanol or LPS or ATP.	Ethanol	0-7	interleukin 1 beta	Mus musculus	349-357
25136295-7	2014	Ethanol-induced NLRP3/caspase-1 activation is mediated by mitochondrial (m) reactive oxygen species (ROS) generation because when using a specific mitochondria ROS scavenger, the mito-TEMPO (500 muM) or NLRP3 blocking peptide (4 mug/ml) or a specific caspase-1 inhibitor, Z-YVAD-FMK (10 muM), abrogates mROS release and reduces the up-regulation of IL-1beta and IL-18 induced by ethanol or LPS or ATP.	Reactive Oxygen Species	101-104	interleukin 1 beta	Mus musculus	349-357
24696323-0	2014	Kaempferol inhibits IL-1beta-stimulated, RANKL-mediated osteoclastogenesis via downregulation of MAPKs, c-Fos, and NFATc1.	kaempferol	0-10	interleukin 1 beta	Mus musculus	20-28
24577726-8	2014	The anti-inflammatory mechanisms of carvacrol may be due to its ability to inhibit NF-kappaB and MAPKs signaling pathways, thereby inhibiting inflammatory cytokines TNF-alpha, IL-6 and IL-1beta production.	carvacrol	36-45	interleukin 1 beta	Mus musculus	185-193
24696323-5	2014	Kaempferol inhibits IL-1beta-stimulated, RANKL-mediated osteoclast differentiation and also inhibits IL-1beta-stimulated, RANKL-mediated phosphorylation of ERK 1/2, p38 and JNK MAP kinases, and expressions of c-Fos and NFATc1.	kaempferol	0-10	interleukin 1 beta	Mus musculus	20-28
24696323-5	2014	Kaempferol inhibits IL-1beta-stimulated, RANKL-mediated osteoclast differentiation and also inhibits IL-1beta-stimulated, RANKL-mediated phosphorylation of ERK 1/2, p38 and JNK MAP kinases, and expressions of c-Fos and NFATc1.	kaempferol	0-10	interleukin 1 beta	Mus musculus	101-109
24706025-5	2014	Triptolide-treated mice exhibited significantly reduced leukocyte, myeloperoxidase (MPO) activity, edema of the lung, as well as TNF-alpha, IL-1beta, and IL-6 production in the bronchoalveolar lavage fluid compared with LPS-treated mice.	triptolide	0-10	interleukin 1 beta	Mus musculus	140-148
24893116-6	2014	On day 3, FTY720 administration reduced PQ-induced increases in lung wet weight/body weight (LW/BW), total protein and cytokine levels including interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in bronchoalceolar lavage fluid (BALF).	Paraquat	40-42	interleukin 1 beta	Mus musculus	145-162
25077824-17	2014	Either high glucose or LPS increased the levels of IL-1beta and TNF-alpha in the conditional medium of peritoneal macrophages.	Glucose	12-19	interleukin 1 beta	Mus musculus	51-59
24474433-3	2014	Latifolin significantly inhibited the protein and mRNA expression of inducible nitric oxide synthase and COX-2, reduced NO, prostaglandins E2, tumor necrosis factor-alpha, and interleukin-1beta production in primary murine peritoneal macrophages exposed to lipopolysaccharide.	latifolin	0-9	interleukin 1 beta	Mus musculus	176-193
24659080-5	2014	Expression of IL-1beta and IL-6 was inhibited both by DEX and Am80.	Dexamethasone	54-57	interleukin 1 beta	Mus musculus	14-22
24659080-5	2014	Expression of IL-1beta and IL-6 was inhibited both by DEX and Am80.	tamibarotene	62-66	interleukin 1 beta	Mus musculus	14-22
25110557-6	2014	In APP/PS1-transgenic mice, chronic oral administration of ADA stem extract (0.1 or 0.5 g/kg/day for six months from the age of six to 12 months) resulted in significantly enhanced performance of the novel-object recognition task, and reduced amyloid deposition and IL-1beta in the brain.	ada stem	59-67	interleukin 1 beta	Mus musculus	266-274
25077824-18	2014	Glibenclamide treatment suppressed the increase of IL-1beta level induced by high glucose and LPS.	Glyburide	0-13	interleukin 1 beta	Mus musculus	51-59
25417305-1	2014	OBJECTIVE: To investigate the relationship between alumina ceramic particles and aseptic loosening of the joint prosthesis and the effect of lanthanum chloride on the secretion of interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) of macrophage RAW264.7 induced by alumina ceramic particles.	lanthanum chloride	141-159	interleukin 1 beta	Mus musculus	180-197
25417305-1	2014	OBJECTIVE: To investigate the relationship between alumina ceramic particles and aseptic loosening of the joint prosthesis and the effect of lanthanum chloride on the secretion of interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) of macrophage RAW264.7 induced by alumina ceramic particles.	lanthanum chloride	141-159	interleukin 1 beta	Mus musculus	199-207
25077824-18	2014	Glibenclamide treatment suppressed the increase of IL-1beta level induced by high glucose and LPS.	Glucose	82-89	interleukin 1 beta	Mus musculus	51-59
25417305-8	2014	CONCLUSION: Alumina ceramic particles can stimulate the secretion of IL-1beta and TNF-alpha of macrophage, and lanthanum chloride can inhibit the secretion of IL-1beta and TNF-alpha of macrophage.	Aluminum Oxide	12-27	interleukin 1 beta	Mus musculus	69-77
25050810-3	2014	In comparison to wild-type (WT) mice, we found that MyD88-KO animals developed attenuated lung inflammation, neutrophil accumulation and IL-1beta release in response to silica.	Silicon Dioxide	169-175	interleukin 1 beta	Mus musculus	137-145
25417305-8	2014	CONCLUSION: Alumina ceramic particles can stimulate the secretion of IL-1beta and TNF-alpha of macrophage, and lanthanum chloride can inhibit the secretion of IL-1beta and TNF-alpha of macrophage.	lanthanum chloride	111-129	interleukin 1 beta	Mus musculus	159-167
25034539-9	2014	Numbers of total immune cells and neutrophils and concentrations of inflammatory mediators (e.g. KC, IL-1beta, IL-17A) were significantly reduced in lungs of moxifloxacin-treated mice infected with inactivated and viable bacterial pathogens as compared to infected control mice.	Moxifloxacin	158-170	interleukin 1 beta	Mus musculus	101-109
25022445-9	2014	Compared with the control group, GLN pretreatment in ALI-challenged mice reduced the levels of receptor for advanced glycation end-products (RAGE) and IL-1beta production in BALF, with a corresponding decrease in their mRNA expression.	Glutamine	33-36	interleukin 1 beta	Mus musculus	151-159
25031415-7	2014	Furthermore, the morphine rewarding effect was blocked in leptin deficient ob/ob mice or by neutralizing leptin or interleukin-1beta in the NAc without diminishing morphine analgesia.	Morphine	17-25	interleukin 1 beta	Mus musculus	115-132
24793808-5	2014	DON markedly induced transient upregulation of TNF-alpha IL-1beta, IL-6, CXCL-2, CCL-2 and CCL-7 mRNA expressions.	deoxynivalenol	0-3	interleukin 1 beta	Mus musculus	57-65
24944605-9	2014	DHMEQ was shown to antagonize the increasing levels of anti-nucleosome, anti-dsDNA and anti-histone autoantibodies, as well as the increasing levels of IL-1beta, 6 and 17 and TNF-alpha.	dehydroxymethylepoxyquinomicin	0-5	interleukin 1 beta	Mus musculus	152-160
24952429-0	2014	Inflammasome activation is reactive oxygen species dependent and mediates irinotecan-induced mucositis through IL-1beta and IL-18 in mice.	Reactive Oxygen Species	27-50	interleukin 1 beta	Mus musculus	111-119
24952429-0	2014	Inflammasome activation is reactive oxygen species dependent and mediates irinotecan-induced mucositis through IL-1beta and IL-18 in mice.	Irinotecan	74-84	interleukin 1 beta	Mus musculus	111-119
24952429-8	2014	Irinotecan treatment resulted in increased IL-1beta and IL-18 production in ileum and NOX-2-dependent oxidative stress.	Irinotecan	0-10	interleukin 1 beta	Mus musculus	43-51
24952429-13	2014	NOX-2-derived oxidative stress mediates inflammasome activation and inflammasome-dependent production of IL-1beta and IL-18, which mediate tissue injury during irinotecan-induced mucositis in mice.	Irinotecan	160-170	interleukin 1 beta	Mus musculus	105-113
24659138-6	2014	The induction of the inflammatory cytokines TGF-beta1, IL-1beta,TNF-alpha, and IL-6 by IR were in turn inhibited in the serum and BALF of the genistein-pretreated mice (P &lt; 0.05).	Genistein	142-151	interleukin 1 beta	Mus musculus	55-63
24685903-0	2014	Purinergic signaling via P2X7 receptor mediates IL-1beta production in Kupffer cells exposed to silica nanoparticle.	Silicon Dioxide	96-102	interleukin 1 beta	Mus musculus	48-56
24685903-7	2014	Treatment of LPS-primed KUP5 cells with ATP also induced a high level of IL-1beta production, similar to that induced by SNP30.	Adenosine Triphosphate	40-43	interleukin 1 beta	Mus musculus	73-81
24685903-8	2014	IL-1beta production was significantly inhibited by apyrase (an ecto-nucleotidase) and A438079 (a P2X7 antagonist/ATP-release inhibitor).	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine	86-93	interleukin 1 beta	Mus musculus	0-8
24685903-11	2014	The ROS causes activation of inflammasomes, leading to caspase-1-dependent processing of IL-1beta.	Reactive Oxygen Species	4-7	interleukin 1 beta	Mus musculus	89-97
24464629-0	2014	Heme induces IL-1beta secretion through activating NLRP3 in kidney inflammation.	Heme	0-4	interleukin 1 beta	Mus musculus	13-21
24464629-5	2014	Here, we find that heme induces IL-1beta secretion through activating NLRP3 inflammasome in macrophages.	Heme	19-23	interleukin 1 beta	Mus musculus	32-40
24464629-8	2014	Our study proves that heme is a potential danger activator of NLRP3 inflammasome that plays an essential role in IL-1beta secretion during kidney inflammation and provides new insight into the mechanism of innate immune initiation.	Heme	22-26	interleukin 1 beta	Mus musculus	113-121
24877626-4	2014	TNF-alpha and IL-1beta were inhibited by TFI administration (5 mg/kg, every other day), the effects of inhibition on cardiac damage were examined, and its mechanism on inflammatory infiltration was further studied in vivo and in vitro.	TFI	41-44	interleukin 1 beta	Mus musculus	14-22
24687687-6	2014	Importantly, NKT cells were found to act as regulators of NLRP3 inflammasome signaling, as NKT-cell-derived TNF-alpha was required for optimal IL-1beta and IL-18 production by myeloid cells in response to alpha-galactosylceramide, by acting on the NLRP3 inflammasome priming step.	alpha-galactosylceramide	205-229	interleukin 1 beta	Mus musculus	143-151
24747094-3	2014	We found that the production of pro-inflammatory mediators, including interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), induced by lipopolysaccharide (LPS) or beta-amyloid (Abeta) was significantly suppressed by daphnetin in a dose-dependent manner in BV2 microglia.	daphnetin	236-245	interleukin 1 beta	Mus musculus	70-87
24789624-5	2014	We found that the exposure of RAW264.7 cells to LPS/ATP triggered the activation of caspase-1 (P&lt;0.01) and the cleavage of interleukin (IL)-1beta (P&lt;0.01), as well as the release of other cytokines, such as IL-18 (P&lt;0.01) and IL-33 (P&lt;0.01).	Adenosine Triphosphate	52-55	interleukin 1 beta	Mus musculus	126-148
24815859-6	2014	CLP-0611 also inhibited TNBS-induced expression of TNF-alpha, IL-1beta, and IL-6.	Trinitrobenzenesulfonic Acid	24-28	interleukin 1 beta	Mus musculus	62-70
24820155-5	2014	The partially hydrolyzed EPS stimulated RAW264.7 cells to induce considerable NO and various cytokine production such as TNF-alpha, IL-1beta, IL-6 and IL-10 via up-regulation of their mRNA expression.	eps	25-28	interleukin 1 beta	Mus musculus	132-140
24789624-0	2014	Lipopolysaccharide/adenosine triphosphate induces IL-1beta and IL-18 secretion through the NLRP3 inflammasome in RAW264.7 murine macrophage cells.	Adenosine Triphosphate	19-41	interleukin 1 beta	Mus musculus	50-58
24859295-14	2014	After dextran sodium sulfate treatment, PM10-fed mice responded with increased colonic tumor necrosis factor alpha and IL-1beta and a larger percentage of PM(10)-fed mice had live bacteria in the mesenteric lymph nodes.	dextran sodium sulfate	6-28	interleukin 1 beta	Mus musculus	119-127
24789624-6	2014	Extracellular potassium chloride at a high concentration (150 mM) abrogated the secretion of IL-1beta and IL-18 (P&lt;0.01), but did not reduce the processing of IL-33 (P&gt;0.05).	Potassium Chloride	14-32	interleukin 1 beta	Mus musculus	93-101
24794016-8	2014	Furthermore, in a murine model of endotoxic shock, treatment with CLA suppressed LPS-induced induction of circulating IFN-gamma, IL-12p40 and IL-1beta.	Linoleic Acids, Conjugated	66-69	interleukin 1 beta	Mus musculus	142-150
25349594-11	2014	Increased expression of IL-1beta, TNF-alpha, and COX-2 was observed in small intestinal tissues exposed to ethanol-induced damage.	Ethanol	107-114	interleukin 1 beta	Mus musculus	24-32
24605772-6	2014	Pretreatment with U0126 or Bay11-7082, respectively, could decrease IL-1beta, IL-6, and TNF-alpha productions induced by OM85-BV.	U 0126	18-23	interleukin 1 beta	Mus musculus	68-76
24605772-6	2014	Pretreatment with U0126 or Bay11-7082, respectively, could decrease IL-1beta, IL-6, and TNF-alpha productions induced by OM85-BV.	3-(4-methylphenylsulfonyl)-2-propenenitrile	27-37	interleukin 1 beta	Mus musculus	68-76
24789089-4	2014	Triptolide-treated mice exhibited significantly reduced levels of leukocytes, myeloperoxidase activity and edema of the lung, as well as tumour necrosis factor-alpha, interleukin (IL)-1beta and IL-6 production in the bronchoalveolar lavage fluid compared with LPS-treated mice.	triptolide	0-10	interleukin 1 beta	Mus musculus	167-189
24972036-4	2014	ATP can evoke the P2X7/caspase 1 dependent release of IL-1beta/IL-18 from EVs; these cytokines are associated with neutrophilia and are increased during exacerbations.	Adenosine Triphosphate	0-3	interleukin 1 beta	Mus musculus	54-62
24972036-5	2014	Thus we hypothesized that respiratory infections causes the release of EVs in the airway and that the raised ATP levels, present in respiratory disease, triggers the release of IL-1beta/IL-18, neutrophilia and subsequent disease exacerbations.	Adenosine Triphosphate	109-112	interleukin 1 beta	Mus musculus	177-185
24972036-9	2014	When exposed to ATP the EVs release IL-1beta/IL-18 via a P2X7/caspase-dependent mechanism.	Adenosine Triphosphate	16-19	interleukin 1 beta	Mus musculus	36-44
24829412-5	2014	Chitosan, but not chitin, induced a robust IL-1beta response in mouse dendritic cells, peritoneal macrophages, and human PBMCs.	Chitosan	0-8	interleukin 1 beta	Mus musculus	43-51
24740538-9	2014	In colonic circular smooth muscle cells isolated from TNBS-treated mice or from strips treated with IL-1beta or TNF-alpha, CPI-17 expression and sustained muscle contraction were decreased.	Trinitrobenzenesulfonic Acid	54-58	interleukin 1 beta	Mus musculus	100-108
26344742-3	2014	We have recently reported that intramuscular injection of PCEP induces NLRP3, an inflammasome receptor gene, and inflammatory cytokines, including IL-1beta and IL-18, in mouse muscle tissue.	poly(bis(carboxylatoethylphenoxy)phosphazene)	58-62	interleukin 1 beta	Mus musculus	147-155
26344742-6	2014	Caspase inhibitor YVAD-fmk-treated splenic DCs showed significantly reduced IL-1beta and IL-18 secretion in response to PCEP stimulation.	tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone	18-26	interleukin 1 beta	Mus musculus	76-84
26344742-6	2014	Caspase inhibitor YVAD-fmk-treated splenic DCs showed significantly reduced IL-1beta and IL-18 secretion in response to PCEP stimulation.	poly(bis(carboxylatoethylphenoxy)phosphazene)	120-124	interleukin 1 beta	Mus musculus	76-84
24619705-0	2014	Polyhydroxylated metallofullerenols stimulate IL-1beta secretion of macrophage through TLRs/MyD88/NF-kappaB pathway and NLRP3 inflammasome activation.	metallofullerenols	17-35	interleukin 1 beta	Mus musculus	46-54
24619705-5	2014	Small interfering RNA (siRNA) knockdown shows that NLRP3 inflammasomes, but not NLRC4, participate in fullerenol-induced IL-1beta production.	fullerenol	102-112	interleukin 1 beta	Mus musculus	121-129
24619705-6	2014	Potassium efflux, activation of P2X7 receptor and intracellular reactive oxygen speciesare also important factors required for fullerenols-induced IL-1beta release.	Potassium	0-9	interleukin 1 beta	Mus musculus	147-155
24619705-6	2014	Potassium efflux, activation of P2X7 receptor and intracellular reactive oxygen speciesare also important factors required for fullerenols-induced IL-1beta release.	reactive oxygen speciesare	64-90	interleukin 1 beta	Mus musculus	147-155
24619705-6	2014	Potassium efflux, activation of P2X7 receptor and intracellular reactive oxygen speciesare also important factors required for fullerenols-induced IL-1beta release.	fullerenol	127-138	interleukin 1 beta	Mus musculus	147-155
24619705-9	2014	Our work demonstrated that fullerenols can greatly activate macrophage and promote IL-1beta production via both TLRs/MyD88/NF-kappaB pathway and NLRP3 inflammasome activation, while Gd@C82(OH)22 had stronger ability C60(OH)22 due to the different electron affinity on the surface of carbon cage induced by the encaged gadolinium ion.	fullerenol	27-38	interleukin 1 beta	Mus musculus	83-91
24263322-8	2014	Atorvastatin evoked significant protection from hippocampal interleukin-1beta production, but not systemic interleukin-1beta production, accompanied by a marked reduction in hippocampal endothelial COX-2, NF-kappaB activation and decreased microglial reactivity.	Atorvastatin	0-12	interleukin 1 beta	Mus musculus	60-77
24751363-8	2014	The expression levels of pro-inflammatory cytokine such as IL-1beta, and TNF-alpha mRNA were significantly reduced by topical application of KSW, whereas these cytokines were increased in DNCB-induced dorsal skin.	ksw	141-144	interleukin 1 beta	Mus musculus	59-67
24911523-1	2014	The omega-3 (omega3) fatty acid docosahexaenoic acid (DHA) can suppress inflammation, specifically IL-1beta production through poorly understood molecular mechanisms.	Fatty Acids, Omega-3	4-31	interleukin 1 beta	Mus musculus	99-107
24911523-1	2014	The omega-3 (omega3) fatty acid docosahexaenoic acid (DHA) can suppress inflammation, specifically IL-1beta production through poorly understood molecular mechanisms.	Docosahexaenoic Acids	32-52	interleukin 1 beta	Mus musculus	99-107
24911523-1	2014	The omega-3 (omega3) fatty acid docosahexaenoic acid (DHA) can suppress inflammation, specifically IL-1beta production through poorly understood molecular mechanisms.	Docosahexaenoic Acids	54-57	interleukin 1 beta	Mus musculus	99-107
24911523-2	2014	Here, we show that DHA reduces macrophage IL-1beta production by limiting inflammasome activation.	Docosahexaenoic Acids	19-22	interleukin 1 beta	Mus musculus	42-50
24911523-3	2014	Exposure to DHA reduced IL-1beta production by ligands that stimulate the NLRP3, AIM2, and NAIP5/NLRC4 inflammasomes.	Docosahexaenoic Acids	12-15	interleukin 1 beta	Mus musculus	24-32
24911523-7	2014	DHA also reduced IL-1beta levels by enhancing autophagy in the cells.	Docosahexaenoic Acids	0-3	interleukin 1 beta	Mus musculus	17-25
24798340-9	2014	Nrf2(-/-) mice showed a dramatic decrease in immune cell recruitment and IL-1beta generation in alum-induced peritonitis, which is a typical IL-1 signaling-dependent inflammation animal model.	aluminum sulfate	96-100	interleukin 1 beta	Mus musculus	73-81
24462946-9	2014	In vitro, glycyrrhizin dose-dependently inhibited the expression of TNF-alpha, IL-6, IL-1beta and RANTES in LPS-stimulated RAW264.7 cells.	Glycyrrhizic Acid	10-22	interleukin 1 beta	Mus musculus	85-93
24286322-5	2014	Furthermore, salicortin significantly inhibited production of pro-inflammatory cytokines, such as TNF-alpha, IL-1beta and IL-6 in the LPS-stimulated RAW 264.7 cells.	salicortin	13-23	interleukin 1 beta	Mus musculus	109-117
24736977-5	2014	CeCl3 exposure also activated nuclear factor kappaB, increased the expression of tumor necrosis factor alpha, cyclooxygenase-2, heme oxygenase 1, interleukin 2, interleukin 4, interleukin 6, interleukin 8, interleukin 10, interleukin 18, interleukin 1beta, and CYP1A1.	cerous chloride	0-5	interleukin 1 beta	Mus musculus	238-255
23413967-3	2014	The in vitro study showed that paeonol regulated the production of TNF-alpha, IL-1beta, IL-6, and IL-10 via inactivation of IkappaBalpha, ERK1/2, JNK, and p38 MAPK.	paeonol	31-38	interleukin 1 beta	Mus musculus	78-86
24676901-6	2014	LTX-315 induced the release of danger-associated molecular pattern molecules such as the high mobility group box-1 protein in vitro and the subsequent upregulation of proinflammatory cytokines such as interleukin (IL) 1beta, IL6 and IL18 in vivo.	LTX-315	0-7	interleukin 1 beta	Mus musculus	201-223
24729619-11	2014	Moreover, poly(I:C) treatment attenuated the levels of TNF-alpha and IL-1beta in serum and cerebral spinal fluid of mice stimulated by LPS.	Poly I-C	10-18	interleukin 1 beta	Mus musculus	69-77
25272846-12	2014	Compared with the LPS model group, total saponins of P. japonicus high, middle and low dose groups (0.1, 1, 10, 40 mg x L(-1)) could significantly reduce the secretion of NO, TNF-alpha, IL-1beta of LPS-induced RAW264.	Saponins	41-49	interleukin 1 beta	Mus musculus	186-194
24886817-6	2014	Bleomycin exposure induced expression of MDA, IKKalpha, phosphorylated IKKalpha (p-IKKalpha), NF-kappaB P65, TNF-alpha and IL-1beta, and reduced I-kappaB expression in mice lung tissue or in BALF.	Bleomycin	0-9	interleukin 1 beta	Mus musculus	123-131
24657625-11	2014	RESULTS: In macrophages and monocytes, increasing concentrations of lactate reduced TLR4-mediated induction of Il1B, Nlrp3, and Casp1; activation of NF-kappaB; release of IL1beta; and cleavage of CASP1.	Lactic Acid	68-75	interleukin 1 beta	Mus musculus	111-115
24657625-11	2014	RESULTS: In macrophages and monocytes, increasing concentrations of lactate reduced TLR4-mediated induction of Il1B, Nlrp3, and Casp1; activation of NF-kappaB; release of IL1beta; and cleavage of CASP1.	Lactic Acid	68-75	interleukin 1 beta	Mus musculus	171-178
24657625-15	2014	CONCLUSIONS: Lactate negatively regulates TLR induction of the NLRP3 inflammasome and production of IL1beta, via ARRB2 and GPR81.	Lactic Acid	13-20	interleukin 1 beta	Mus musculus	100-107
24905526-4	2014	Among the synthesized derivatives, the BECT [But-2-enedioic acid bis-(2-carboxy-5-trifluoromethyl-phenyl) ester] significantly decreased production of nitric oxide and other pro-inflammatory cytokines including tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 in microglial cells.	bect [but-2-enedioic acid bis-(2-carboxy-5-trifluoromethyl-phenyl) ester	39-111	interleukin 1 beta	Mus musculus	240-257
24905526-4	2014	Among the synthesized derivatives, the BECT [But-2-enedioic acid bis-(2-carboxy-5-trifluoromethyl-phenyl) ester] significantly decreased production of nitric oxide and other pro-inflammatory cytokines including tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 in microglial cells.	Nitric Oxide	151-163	interleukin 1 beta	Mus musculus	240-257
24886543-7	2014	RESULTS: DHEA was associated with a decrease in the systemic inflammatory response induced by bilateral femoral fracture, especially systemic IL-6 (322.2 vs. 62.5 pg/mL; P = 0.01), IL-1beta (1,422.6 vs. 754.1 pg/mL; P = 0.05), and MCP-1 (219.4 vs. 44.1 pg/mL; P &gt;0.01) levels.	Dehydroepiandrosterone	9-13	interleukin 1 beta	Mus musculus	181-189
24810606-5	2014	Aromatic pyruvates reduced cytotoxicity in UVB-irradiated HaCaT keratinocytes, and also diminished the expression of interleukin 1beta (IL-1beta) and interleukin 6 (IL-6).	aromatic pyruvates	0-18	interleukin 1 beta	Mus musculus	117-134
24732350-5	2014	CS exposure induced lymphocyte, neutrophil and macrophage infiltration and inflammatory cytokine (IL-1beta, tumor necrosis factor-alpha (TNF)-alpha, IL-17, and IL-4) in the airways.	Cesium	0-2	interleukin 1 beta	Mus musculus	98-106
24810606-5	2014	Aromatic pyruvates reduced cytotoxicity in UVB-irradiated HaCaT keratinocytes, and also diminished the expression of interleukin 1beta (IL-1beta) and interleukin 6 (IL-6).	aromatic pyruvates	0-18	interleukin 1 beta	Mus musculus	136-144
24810606-9	2014	Overproduction of IL-1beta and IL-6 in response to UVB radiation was also suppressed in vivo by the topical administration of IPyr.	indol-3-yl pyruvic acid	126-130	interleukin 1 beta	Mus musculus	18-26
24885161-9	2014	SB203580 significantly attenuated lung inflammation (neutrophil infiltration, mRNA expressions of TNF-alpha and MIP-2, protein levels of KC, MIP-1alpha, IL-1beta, and IL-6), proteinase expression (MMP-12 mRNA), oxidative DNA damage, and apoptosis caused by acute CS exposure.	SB 203580	0-8	interleukin 1 beta	Mus musculus	153-161
24593990-7	2014	Concurrently, levels of the pro-inflammatory cytokines TNF-alpha, IL-1beta, and IL-6 were reduced with increasing concentrations of SD.	SD 0006	132-134	interleukin 1 beta	Mus musculus	66-74
24470226-3	2014	To understand the mechanism by which LiCl affects catabolic events in articular chondrocytes after IL-1beta treatment, the activation of NF-kappaB was determined using luciferase reporter assays, and the activities of MAPKs and the STAT-3 signaling pathway were determined by immunoblot analysis of total cell lysates.	Lithium Chloride	37-41	interleukin 1 beta	Mus musculus	99-107
24470226-5	2014	RESULTS: LiCl treatment resulted in decreased catabolic marker messenger RNA levels and activation of NF-kappaB, p38 MAPK, and STAT-3 signaling in IL-1beta-treated articular chondrocytes.	Lithium Chloride	9-13	interleukin 1 beta	Mus musculus	147-155
24470226-7	2014	Consequently, the loss of proteoglycan and severity of cartilage destruction in LiCl-treated mouse knee joints 8 weeks after OA induction surgery or in LiCl-treated mouse femoral head explants after IL-1beta treatment were markedly reduced compared to that in vehicle-treated joints or explants.	Lithium Chloride	80-84	interleukin 1 beta	Mus musculus	199-207
24470226-7	2014	Consequently, the loss of proteoglycan and severity of cartilage destruction in LiCl-treated mouse knee joints 8 weeks after OA induction surgery or in LiCl-treated mouse femoral head explants after IL-1beta treatment were markedly reduced compared to that in vehicle-treated joints or explants.	Lithium Chloride	152-156	interleukin 1 beta	Mus musculus	199-207
24412646-7	2014	CAF rapidly increased IL-1beta and TNF-alpha signaling in WT mice.	cafestol palmitate	0-3	interleukin 1 beta	Mus musculus	22-30
24727148-7	2014	Furthermore, western blot analysis showed that UA significantly decreased CYP2E1 expression levels and production of pro-inflammatory markers including TNF-alpha, IL-1beta and COX-2 in CCl(4)-treated mouse liver.	ursolic acid	47-49	interleukin 1 beta	Mus musculus	163-171
24940420-6	2014	In addition, glycyrrhizin pretreatment appeared to ameliorate I/R-induced renal injury via inhibition of inflammatory cell infiltration, as well as the production of pro-inflammatory cytokines, including tumor necrosis factor-alpha, interferon-gamma, interleukin (IL)-1beta and IL-6.	Glycyrrhizic Acid	13-25	interleukin 1 beta	Mus musculus	251-273
24631024-5	2014	Both renal injury and renal IL-1beta and IL-17A production were attenuated in Asc(-/-) and Tlr2(-/-) mice, suggesting that cisplatin induces endogenous TLR2 ligand production and activates the ASC-dependent inflammasome complex, resulting in IL-1beta and injurious IL-17A production.	Cisplatin	123-132	interleukin 1 beta	Mus musculus	28-36
24607272-8	2014	PMFA significantly decreased the expression of IL-1beta, IL-6 and TNF-alpha and reduced the infiltration of M1 macrophages in lung.	pmfa	0-4	interleukin 1 beta	Mus musculus	47-55
24583148-12	2014	Our study suggests that hemin-inhibited NLRP3 inflammasome activation involved HO-1, reducing IL-1beta and IL-18 secretion and limiting the inflammatory response.	Hemin	24-29	interleukin 1 beta	Mus musculus	94-102
24508537-6	2014	The results showed that curcumin attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), and the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in a dose-dependent manner.	Curcumin	24-32	interleukin 1 beta	Mus musculus	211-228
24508537-6	2014	The results showed that curcumin attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), and the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in a dose-dependent manner.	Curcumin	24-32	interleukin 1 beta	Mus musculus	230-238
24325781-6	2014	Tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta, and nuclear factor-kappa B mRNA expression in the colonic mucosa was significantly lower in animals fed 0.10% glucosamine compared with those of the control group.	Glucosamine	170-181	interleukin 1 beta	Mus musculus	41-58
24447140-0	2014	Inhibition of interleukin-1beta production by extracellular acidification through the TDAG8/cAMP pathway in mouse microglia.	Cyclic AMP	92-96	interleukin 1 beta	Mus musculus	14-31
24663678-8	2014	In agreement with the increased IL-19 expression in IMQ-treated mouse skin, IL-1beta markedly upregulated expression of acanthosis-inducing cytokine IL-19 in human keratinocytes.	Imiquimod	52-55	interleukin 1 beta	Mus musculus	76-84
24447140-6	2014	Forskolin and a cAMP derivative, which specifically stimulates protein kinase A (PKA), mimicked the proton actions, and PKA inhibitors reversed the acidic pH-induced IL-1beta mRNA expression.	Colforsin	0-9	interleukin 1 beta	Mus musculus	166-174
24447140-6	2014	Forskolin and a cAMP derivative, which specifically stimulates protein kinase A (PKA), mimicked the proton actions, and PKA inhibitors reversed the acidic pH-induced IL-1beta mRNA expression.	Cyclic AMP	16-20	interleukin 1 beta	Mus musculus	166-174
24447140-9	2014	We conclude that extracellular acidic pH inhibits lipopolysaccharide-induced IL-1beta production, at least partly, through the TDAG8/cAMP/PKA pathway, by inhibiting extracellular signal-related kinase and c-Jun N-terminal kinase activities, in mouse microglia.	Cyclic AMP	133-137	interleukin 1 beta	Mus musculus	77-85
24737908-1	2014	OBJECTIVE: To determine the effect of hyaluronic acid (HA) on proteolytic enzymes and bone remodeling mediators induced by interleukin 1beta (IL-1beta) and related to cartilage catabolism in murine osteoblasts.	Hyaluronic Acid	38-53	interleukin 1 beta	Mus musculus	123-140
24737908-1	2014	OBJECTIVE: To determine the effect of hyaluronic acid (HA) on proteolytic enzymes and bone remodeling mediators induced by interleukin 1beta (IL-1beta) and related to cartilage catabolism in murine osteoblasts.	Hyaluronic Acid	38-53	interleukin 1 beta	Mus musculus	142-150
24737908-1	2014	OBJECTIVE: To determine the effect of hyaluronic acid (HA) on proteolytic enzymes and bone remodeling mediators induced by interleukin 1beta (IL-1beta) and related to cartilage catabolism in murine osteoblasts.	Hyaluronic Acid	55-57	interleukin 1 beta	Mus musculus	123-140
24737908-1	2014	OBJECTIVE: To determine the effect of hyaluronic acid (HA) on proteolytic enzymes and bone remodeling mediators induced by interleukin 1beta (IL-1beta) and related to cartilage catabolism in murine osteoblasts.	Hyaluronic Acid	55-57	interleukin 1 beta	Mus musculus	142-150
24689881-11	2014	The serum level of IL-1beta was also inhibited by 1 in a carrageenan-induced paw edema model.	Carrageenan	57-68	interleukin 1 beta	Mus musculus	19-27
24474616-9	2014	In accordance with the data from cell culture model, THC exhibited increased expression of HO-1 in kidney and decreased serum level of pro-inflammatory mediators such as TNF-alpha, IL-1beta, and NO.	Dronabinol	53-56	interleukin 1 beta	Mus musculus	181-189
25026715-4	2014	Furthermore, the five compounds isolated from the ethyl acetate extract of Cassia occidentalis roots were found to suppress LPS-induced IL-1beta, TNF-alpha and NO production in a concentration-dependent manner in these cells at 1C50 values ranging from 22.5 to 97.4 microM.	ethyl acetate	50-63	interleukin 1 beta	Mus musculus	136-144
24717804-4	2014	METHODS: The insulin-producing cell line beta-TC6 was exposed to the proinflammatory cytokines interleukin 1beta(+) interferon gamma, or hydrogen peroxide.	beta-tc6	41-49	interleukin 1 beta	Mus musculus	95-112
24712394-6	2014	GPP-S also had inhibitory activities on IL-1beta, IL-6, and COX-2 gene expressions in RAW 264.7 mouse macrophage cells.	gpp-s	0-5	interleukin 1 beta	Mus musculus	40-48
24566851-8	2014	Upon pharmacological inhibition of the JNK/c-Jun pathway with CE11004 or SP600125, the expression of PUMA was notably suppressed with a concomitant decrease in apoptosis observed in IL-1beta-treated chondrocytes.	ce11004	62-69	interleukin 1 beta	Mus musculus	182-190
24566851-8	2014	Upon pharmacological inhibition of the JNK/c-Jun pathway with CE11004 or SP600125, the expression of PUMA was notably suppressed with a concomitant decrease in apoptosis observed in IL-1beta-treated chondrocytes.	pyrazolanthrone	73-81	interleukin 1 beta	Mus musculus	182-190
24966921-6	2014	Pretreatment with diosmetin significantly reduced serum levels of amylase and lipase; the histological injury; the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6; myeloperoxidase (MPO) activity, trypsinogen activation peptide (TAP) level, the expression of inducible nitric oxide synthase (iNOS); and the nuclear factor (NF)-kappaB activation in cerulein-induced AP.	diosmetin	18-27	interleukin 1 beta	Mus musculus	163-185
24743742-5	2014	Treatment with TNF-alpha/IL-1beta inhibited BMP-2-induced alkaline phosphatase activity, calcium deposition, osteogenic transcriptional factor Runx2, and the expression of osteogenic markers in C2C12 and MC3T3-E1 cells.	Calcium	89-96	interleukin 1 beta	Mus musculus	25-33
24722370-7	2014	In cultured rodent astrocytes, raloxifene inhibited IL-1beta-induced CCL20 expression and chemotaxis ability for Th17 migration, whereas the estrogen receptor antagonist ICI 182,780 blocked this effect.	Raloxifene Hydrochloride	31-41	interleukin 1 beta	Mus musculus	52-60
24534266-4	2014	This treatment revealed corticosterone-dependent increases in microglial number and accumulation of the pro-inflammatory cytokines interleukin 1beta and tumor necrosis factor alpha in the hippocampus of db/db mice.	Corticosterone	24-38	interleukin 1 beta	Mus musculus	131-180
24722370-8	2014	Western blotting further indicated that raloxifene suppresses IL-1beta-induced NF-kappaB activation (phosphorylation of p65) and translocation but does not affect phosphorylation of IkappaB.	Raloxifene Hydrochloride	40-50	interleukin 1 beta	Mus musculus	62-70
24705413-7	2014	The serum level of IL-1ra elicited by the injection of DH-PS was over 10 folds of IL-1beta, suggesting that DH-PS-induced anti-inflammatory activities might over-ride the inflammatory ones mediated by IL-1beta.	dh-ps	55-60	interleukin 1 beta	Mus musculus	82-90
24485892-6	2014	(2R, 3R)-Obtusafuran (1) also reduced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production, and these anti-neuroinflammatory effects were shown to be correlated with the suppression of the phosphorylation and degradation of inhibitor of nuclear factor kappa B-alpha (IkappaB-alpha), and nuclear factor kappa B nuclear (NF-kappaB) translocation and DNA binding activity.	obtusafuran	9-20	interleukin 1 beta	Mus musculus	82-99
24485892-6	2014	(2R, 3R)-Obtusafuran (1) also reduced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production, and these anti-neuroinflammatory effects were shown to be correlated with the suppression of the phosphorylation and degradation of inhibitor of nuclear factor kappa B-alpha (IkappaB-alpha), and nuclear factor kappa B nuclear (NF-kappaB) translocation and DNA binding activity.	obtusafuran	9-20	interleukin 1 beta	Mus musculus	101-109
24705413-7	2014	The serum level of IL-1ra elicited by the injection of DH-PS was over 10 folds of IL-1beta, suggesting that DH-PS-induced anti-inflammatory activities might over-ride the inflammatory ones mediated by IL-1beta.	dh-ps	55-60	interleukin 1 beta	Mus musculus	201-209
24705413-7	2014	The serum level of IL-1ra elicited by the injection of DH-PS was over 10 folds of IL-1beta, suggesting that DH-PS-induced anti-inflammatory activities might over-ride the inflammatory ones mediated by IL-1beta.	dh-ps	108-113	interleukin 1 beta	Mus musculus	82-90
24705413-7	2014	The serum level of IL-1ra elicited by the injection of DH-PS was over 10 folds of IL-1beta, suggesting that DH-PS-induced anti-inflammatory activities might over-ride the inflammatory ones mediated by IL-1beta.	dh-ps	108-113	interleukin 1 beta	Mus musculus	201-209
24417187-8	2014	However, only azithromycin reduced IL-1beta levels in the lung 24 h post LPS challenge.	Azithromycin	14-26	interleukin 1 beta	Mus musculus	35-43
24152048-10	2014	The increased neutrophils, and accompanying cytokines/chemokines KC and IL-1beta induced by poly(I:C) challenge of HDM-sensitized and challenged mice were insensitive to oral prednisone therapy.	poly	92-96	interleukin 1 beta	Mus musculus	72-80
24576689-7	2014	Treatment with baicalein decreased the upregulation of cytokines (tumor necrosis factor-alpha and interleukin-1beta) in the substantia nigra and striatum in the mice injected with MPTP.	baicalein	15-24	interleukin 1 beta	Mus musculus	98-115
24576689-7	2014	Treatment with baicalein decreased the upregulation of cytokines (tumor necrosis factor-alpha and interleukin-1beta) in the substantia nigra and striatum in the mice injected with MPTP.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	180-184	interleukin 1 beta	Mus musculus	98-115
24456163-7	2014	A metabolomics profile identified elevated circulating levels of tricarboxyclic acid cycle intermediates including succinate, an inducer of IL-1beta, in PEDF KO mice.	tricarboxyclic acid	65-84	interleukin 1 beta	Mus musculus	140-148
24456163-7	2014	A metabolomics profile identified elevated circulating levels of tricarboxyclic acid cycle intermediates including succinate, an inducer of IL-1beta, in PEDF KO mice.	Succinic Acid	115-124	interleukin 1 beta	Mus musculus	140-148
24456163-8	2014	Succinate-dependent IL-1beta expression was blocked by PEDF in PEDF KO, but not wild-type hepatocytes.	Succinic Acid	0-9	interleukin 1 beta	Mus musculus	20-28
24677196-6	2014	Upon poly(I:C) treatment, IFNAR-deficient mice displayed both a severe lack of IL-1RA production and an increased production of proinflammatory IL-1beta, indicating a severely imbalanced cytokine milieu in the liver in absence of a functional type I IFN system.	Poly I-C	5-13	interleukin 1 beta	Mus musculus	144-152
23793223-2	2014	DESIGN: Dextran sodium sulfate (DSS) colitis was induced in mice globally deficient in either IL-1alpha or IL-1beta, and in wild-type mice, or in mice with conditional deletion of IL-1alpha in intestinal epithelial cells (IECs).	dextran sodium sulfate	8-30	interleukin 1 beta	Mus musculus	107-115
23793223-2	2014	DESIGN: Dextran sodium sulfate (DSS) colitis was induced in mice globally deficient in either IL-1alpha or IL-1beta, and in wild-type mice, or in mice with conditional deletion of IL-1alpha in intestinal epithelial cells (IECs).	dss	32-35	interleukin 1 beta	Mus musculus	107-115
23793223-8	2014	CONCLUSIONS: The role of IL-1alpha and IL-1beta differs in DSS-induced colitis in that IL-1alpha, mainly of colon epithelial cells is inflammatory, whereas IL-1beta, mainly of myeloid cell origin, promotes healing and repair.	dss	59-62	interleukin 1 beta	Mus musculus	39-47
23793223-8	2014	CONCLUSIONS: The role of IL-1alpha and IL-1beta differs in DSS-induced colitis in that IL-1alpha, mainly of colon epithelial cells is inflammatory, whereas IL-1beta, mainly of myeloid cell origin, promotes healing and repair.	dss	59-62	interleukin 1 beta	Mus musculus	156-164
24677196-7	2014	Depletion of IL-1beta or treatment with recombinant IL-1RA both rescued IFNAR-deficient mice from poly(I:C)-induced liver damage, directly linking the deregulated IL-1beta and IL-1RA production to liver pathology.	Poly I-C	98-107	interleukin 1 beta	Mus musculus	13-21
24677196-7	2014	Depletion of IL-1beta or treatment with recombinant IL-1RA both rescued IFNAR-deficient mice from poly(I:C)-induced liver damage, directly linking the deregulated IL-1beta and IL-1RA production to liver pathology.	Poly I-C	98-107	interleukin 1 beta	Mus musculus	163-171
24535427-5	2014	Furthermore, the release and expression of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), were inhibited by 7,8-DHF.	6,7-dihydroxyflavone	169-176	interleukin 1 beta	Mus musculus	121-138
24754049-3	2014	Treatment of C57BL/6 mice with ethanol and cerulein resulted in increased staining for acinar interleukin- 1b (IL-1b), chemokine (C-C motif) ligand 3 (CCL3), or connective tissue growth factor (CTGF/CCN2) by Day 16 and this was associated with increased infiltration of F4/80-positive macrophages and increased expression of pancreatic CTGF/CCN2 mRNA.	Ethanol	31-38	interleukin 1 beta	Mus musculus	94-109
24754049-3	2014	Treatment of C57BL/6 mice with ethanol and cerulein resulted in increased staining for acinar interleukin- 1b (IL-1b), chemokine (C-C motif) ligand 3 (CCL3), or connective tissue growth factor (CTGF/CCN2) by Day 16 and this was associated with increased infiltration of F4/80-positive macrophages and increased expression of pancreatic CTGF/CCN2 mRNA.	Ethanol	31-38	interleukin 1 beta	Mus musculus	111-116
24754049-7	2014	These results reveal that acinar CTGF/CCN2 plays a novel role in alcohol-induced inflammatory processes in the pancreas by increasing infiltration of macrophages and neutrophils and increasing acinar production of inflammatory mediators such as IL-1b or CCL3.	Alcohols	65-72	interleukin 1 beta	Mus musculus	245-250
24197825-4	2014	We found that 1,8-cineol significantly decreased the level of TNF-alpha and IL-1beta, and increased the level of IL-10 in lung tissues after acute lung injury induced by lipopolysaccharide (LPS).	Eucalyptol	14-24	interleukin 1 beta	Mus musculus	76-84
24503166-7	2014	The results showed that CPA significantly increased mice survival rates and down-regulated LPS-induced interleukin (IL)-6, IL-1beta and macrophage chemo-attractant protein (MCP)-1 in serum.	cpa	24-27	interleukin 1 beta	Mus musculus	123-131
24588616-9	2014	The investigated hydrazide, at the highest used concentration of 150 mug/ml, increased the LPS-induced production of IL-1beta and did not affect the level of TNF-alpha.	Isoniazid	17-26	interleukin 1 beta	Mus musculus	117-125
23764428-3	2014	We observed that resveratrol treatment significantly reduced glial activation, decreasing the levels of IL-1beta, IL-6 and TNF-alpha, as well as their respective receptors in the SNpc of MPTP-treated mice, as demonstrated by Western blotting, RT-PCR and quantitative PCR analysis.	Resveratrol	17-28	interleukin 1 beta	Mus musculus	104-112
23764428-3	2014	We observed that resveratrol treatment significantly reduced glial activation, decreasing the levels of IL-1beta, IL-6 and TNF-alpha, as well as their respective receptors in the SNpc of MPTP-treated mice, as demonstrated by Western blotting, RT-PCR and quantitative PCR analysis.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	187-191	interleukin 1 beta	Mus musculus	104-112
24548765-8	2014	The results showed that taraxasterol attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), lung wet/dry ratio, and the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in a dose-dependent manner.	taraxasterol	24-36	interleukin 1 beta	Mus musculus	235-252
24548765-8	2014	The results showed that taraxasterol attenuated the infiltration of inflammatory cells, the activity of myeloperoxidase (MPO), lung wet/dry ratio, and the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) in a dose-dependent manner.	taraxasterol	24-36	interleukin 1 beta	Mus musculus	254-262
24535427-5	2014	Furthermore, the release and expression of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), were inhibited by 7,8-DHF.	6,7-dihydroxyflavone	169-176	interleukin 1 beta	Mus musculus	140-148
24464856-3	2014	The present study investigates whether GLP-1 (7-36) amide, an active fragment of GLP-1, protected against synaptic impairments induced by inflammation-related injurious agents (lipopolysaccharide [LPS], interleukin-1beta [IL-1beta], and H2 O2).	Amides	52-57	interleukin 1 beta	Mus musculus	203-220
24600030-8	2014	We show that DNFB triggers DETC activation and IL-1beta production in the skin and that keratinocytes produce IL-1beta when stimulated with DNFB.	Dinitrofluorobenzene	13-17	interleukin 1 beta	Mus musculus	47-55
24600030-8	2014	We show that DNFB triggers DETC activation and IL-1beta production in the skin and that keratinocytes produce IL-1beta when stimulated with DNFB.	Dinitrofluorobenzene	140-144	interleukin 1 beta	Mus musculus	110-118
24464856-3	2014	The present study investigates whether GLP-1 (7-36) amide, an active fragment of GLP-1, protected against synaptic impairments induced by inflammation-related injurious agents (lipopolysaccharide [LPS], interleukin-1beta [IL-1beta], and H2 O2).	Amides	52-57	interleukin 1 beta	Mus musculus	222-230
24565673-5	2014	Interleukin 1beta (IL-1beta) messenger RNA (mRNA) levels were significantly decreased by all berry anthocyanins at 10 mug/ml or higher.	Anthocyanins	99-111	interleukin 1 beta	Mus musculus	0-17
24565673-5	2014	Interleukin 1beta (IL-1beta) messenger RNA (mRNA) levels were significantly decreased by all berry anthocyanins at 10 mug/ml or higher.	Anthocyanins	99-111	interleukin 1 beta	Mus musculus	19-27
24565673-10	2014	However, in the BMM from Nrf2(-/-) mice, the anthocyanin fractions were able to significantly decrease IL-1beta mRNA despite the fact that ROS levels were not significantly affected.	Anthocyanins	45-56	interleukin 1 beta	Mus musculus	103-111
24603330-7	2014	Removing extracellular ATP with systemic apyrase treatment not only prevented IL-1beta accumulation but also the production of inflammasome-independent cytokines such as TNF and IL-10.	Adenosine Triphosphate	23-26	interleukin 1 beta	Mus musculus	78-86
24534870-4	2014	A non-cytotoxic methanol extract of AT inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to significantly reduced levels of nitric oxide (NO) and prostaglandin E2 (PGE2) and of two proteins regulated by these, interleukin-1beta (IL-1beta) and IL-6, in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells.	Methanol	16-24	interleukin 1 beta	Mus musculus	255-272
24534870-4	2014	A non-cytotoxic methanol extract of AT inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to significantly reduced levels of nitric oxide (NO) and prostaglandin E2 (PGE2) and of two proteins regulated by these, interleukin-1beta (IL-1beta) and IL-6, in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells.	Methanol	16-24	interleukin 1 beta	Mus musculus	274-282
24456746-5	2014	Blockade of CysLT1R by repeated treatment with montelukast (1 or 2 mg/kg, ig, 4 weeks) reduced Abeta1-42-induced CysLT1R expression and also suppressed Abeta1-42-induced increments of NF-kappaB p65, TNF-alpha, IL-1beta and caspase-3 activation, and Bcl-2 downregulation in the hippocampus and cortex.	montelukast	47-58	interleukin 1 beta	Mus musculus	210-218
24690681-6	2014	Moreover, exposure to non-toxic concentrations of thimerosal induced cell cycle arrest in G0/G1 phase of TCR-activated T cells, and inhibition of the release of proinflammatory cytokines such as IFN gamma, IL-1 beta, TNF alpha, IL-2, as well as the chemokine MCP1.	Thimerosal	50-60	interleukin 1 beta	Mus musculus	206-215
24434771-5	2014	Moreover, the antidepressant action of etazolate was paralleled by significantly reducing the expression levels of PDE4A, PDE4B, PDE4D and IL-1beta and up-regulating the cAMP/phosphorylated cAMP response-element binding protein (pCREB)/brain-derived neurotrophic factor (BDNF) signaling in the hippocampus and prefrontal cortex of mice.	Etazolate	39-48	interleukin 1 beta	Mus musculus	139-147
24645646-11	2014	We also found that EMF exposure significantly increased the secretion of pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-1beta) and the production of NO; however, these increases were efficiently chilled by the addition of curcumin to the culture medium.	Curcumin	226-234	interleukin 1 beta	Mus musculus	121-129
24618279-11	2014	Notably, IL-1beta and IL-2 were significantly increased in Tlr4-/- mice but not in the C57BL/6 mice when the PI3K pathway was inhibited by LY294002 prior to LPS injection.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	139-147	interleukin 1 beta	Mus musculus	9-17
24481726-3	2014	In addition, 5HHMF inhibited the release of pro-inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-1beta, and decreased the transcriptional levels.	5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone	13-18	interleukin 1 beta	Mus musculus	112-129
24430548-3	2014	The experiments in vitro showed that baicalin inhibited both viability of macrophages and the cell"s secretion of HMGB1, tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-1beta induced by lipopolysaccharide.	baicalin	37-45	interleukin 1 beta	Mus musculus	176-184
24676213-9	2014	The expressions of KGF, p21, TNF-alpha and IL-1beta, which are keratinocyte terminal differentiation markers associated with catagen, were modulated by treatment with Astragaloside IV.	astragaloside A	167-183	interleukin 1 beta	Mus musculus	43-51
24681489-5	2014	Of note, 30 nm-1000 nm diameter silica particles induced lysosomal destabilization, cell death, and IL-1beta secretion at markedly higher levels than did 3000 nm-10000 nm silica particles.	Silicon Dioxide	32-38	interleukin 1 beta	Mus musculus	100-108
24192281-5	2014	In response to the addition of proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma to the culture medium, primary osteoblasts showed increased production of nitric oxide (NO) and prostaglandin E2 (PGE2) at early time points and decreases in cell viability.	Nitric Oxide	200-212	interleukin 1 beta	Mus musculus	57-103
24192281-5	2014	In response to the addition of proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma to the culture medium, primary osteoblasts showed increased production of nitric oxide (NO) and prostaglandin E2 (PGE2) at early time points and decreases in cell viability.	Dinoprostone	222-238	interleukin 1 beta	Mus musculus	57-103
24192281-5	2014	In response to the addition of proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma to the culture medium, primary osteoblasts showed increased production of nitric oxide (NO) and prostaglandin E2 (PGE2) at early time points and decreases in cell viability.	Dinoprostone	240-244	interleukin 1 beta	Mus musculus	57-103
24618100-6	2014	RESULTS: Paroxetine significantly inhibited LPS-induced production of nitric oxide (NO) and pro-inflammatory cytokines such as TNF-alpha and IL-1beta.	Paroxetine	9-19	interleukin 1 beta	Mus musculus	141-149
24618100-7	2014	Further analysis showed inducible nitric oxide synthase (iNOS) and mRNA expression of TNF-alpha and IL-1beta were attenuated by paroxetine pretreatment.	Paroxetine	128-138	interleukin 1 beta	Mus musculus	100-108
24424052-9	2014	Moreover, bilirubin suppressed macrophage infiltration and proinflammatory cytokine expression, including TNF-alpha, IL-1beta, and monocyte chemoattractant protein-1, in adipose tissue.	Bilirubin	10-19	interleukin 1 beta	Mus musculus	117-125
24593993-12	2014	Cav-3 KO CCI showed increased IL-1beta, IL-9, KC, MCP-1, MIP-1alpha, and granulocyte-macrophage colony-stimulating factor in ipsilateral and IL-1beta, IL-2, IL-9, IL-10, and IL-17 in contralateral hemispheres (P = 0.0005, n = 6; two-way ANOVA) compared to Cav-1 KO CCI.	CCI	9-12	interleukin 1 beta	Mus musculus	30-38
24593993-12	2014	Cav-3 KO CCI showed increased IL-1beta, IL-9, KC, MCP-1, MIP-1alpha, and granulocyte-macrophage colony-stimulating factor in ipsilateral and IL-1beta, IL-2, IL-9, IL-10, and IL-17 in contralateral hemispheres (P = 0.0005, n = 6; two-way ANOVA) compared to Cav-1 KO CCI.	CCI	9-12	interleukin 1 beta	Mus musculus	141-149
24283717-8	2014	NMDA induced glial activation, expression of TNF-alpha and IL-1beta that co-localized with Muller cells in WT but not TKO mice.	N-Methylaspartate	0-4	interleukin 1 beta	Mus musculus	59-67
24283717-9	2014	In parallel, NMDA triggered the expression of NOD-like receptor protein (NLRP3), activation of caspase-1, and release of IL-1beta and TNF-alpha in primary WT but not TKO Muller cultures.	N-Methylaspartate	13-17	interleukin 1 beta	Mus musculus	121-129
24194505-3	2014	Soluble factors in the biochemical milieu of these wounds are sufficient to activate the inflammasome, as wound-conditioned medium activates caspase-1 and induces release of interleukin (IL)-1beta and IL-18 in cultured Mp via a reactive oxygen species-mediated pathway.	Reactive Oxygen Species	228-251	interleukin 1 beta	Mus musculus	174-196
24055516-10	2014	Trans-caryophyllene treatment also decreased the IL-1beta levels.	caryophyllene	0-19	interleukin 1 beta	Mus musculus	49-57
24379178-8	2014	Treatment with azilsartan or Ang-(1-7) attenuated neointimal area, vascular smooth muscle cell proliferation, increases in the mRNA levels of monocyte chemoattractant protein-1, tumor necrosis factor-alpha, and interleukin-1beta, and superoxide anion production in the injured artery; however, these inhibitory effects of azilsartan and Ang-(1-7) were less marked in Mas-knockout mice.	azilsartan	15-25	interleukin 1 beta	Mus musculus	211-228
24587153-12	2014	Inactivation of caspase-1 by luteoloside resulted in inhibition of IL-1beta.	luteolin-7-glucoside	29-40	interleukin 1 beta	Mus musculus	67-75
24462389-4	2014	We found that LBPF4-OL can significantly induce TNF-alpha and IL-1beta production in peritoneal macrophages isolated from wild-type (C3H/HeN) but not TLR4-deficient mice (C3H/HeJ).	lbpf4-ol	14-22	interleukin 1 beta	Mus musculus	62-70
24333781-0	2014	Prostacyclin mediates neuropathic pain through interleukin 1beta-expressing resident macrophages.	Epoprostenol	0-12	interleukin 1 beta	Mus musculus	47-64
24333781-5	2014	Local administration of the IP agonist cicaprost inhibited macrophage migration in vitro and promoted accumulation of IP- and IL1beta-expressing cells as well as an increase of IL1beta concentrations at the application site in vivo.	cicaprost	39-48	interleukin 1 beta	Mus musculus	126-133
24333781-5	2014	Local administration of the IP agonist cicaprost inhibited macrophage migration in vitro and promoted accumulation of IP- and IL1beta-expressing cells as well as an increase of IL1beta concentrations at the application site in vivo.	cicaprost	39-48	interleukin 1 beta	Mus musculus	177-184
24333781-8	2014	Thus, early synthesis of prostacyclin at the site of injury causes accumulation of IL1beta-expressing macrophages as a key step in neuropathic pain after traumatic injury.	Epoprostenol	25-37	interleukin 1 beta	Mus musculus	83-90
24551028-7	2014	Measurement of tissue cytokines revealed that interleukin-1 beta (IL-1beta) expression in CaTx-II treated mice was significantly suppressed versus untreated controls.	catx-ii	90-97	interleukin 1 beta	Mus musculus	46-64
24366170-8	2014	IL-1beta-mediated dextran leakage from a lung endothelial cell monolayer was also blocked by coculture with NK cells from wild-type mice but not from IL-10 knockout mice.	Dextrans	18-25	interleukin 1 beta	Mus musculus	0-8
24551028-7	2014	Measurement of tissue cytokines revealed that interleukin-1 beta (IL-1beta) expression in CaTx-II treated mice was significantly suppressed versus untreated controls.	catx-ii	90-97	interleukin 1 beta	Mus musculus	66-74
24498418-7	2014	Pretreatment with ethyl pyruvate ameliorated the pathological effects of Con A-induced autoimmune hepatitis and significantly decreased the levels of TNF-alpha, IL-2, IL-6 and IL-1beta at 3h and 6h and the level of HMGB1 at 6h and 24h post injection.	ethyl pyruvate	18-32	interleukin 1 beta	Mus musculus	176-184
24361309-4	2014	Treatment of RAW 264.7 cells with chicanine down-regulated LPS-induced expression of pro-inflammatory cytokines including TNFalpha, IL-1beta, MCP-1, G-CSF, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	chicanine	34-43	interleukin 1 beta	Mus musculus	132-140
24316441-4	2014	Curcumin treatment greatly reduced the astrogliosis in SCI mice and significantly decreased the expression of IL-1beta and NO, as well as the number of Iba1(+) inflammatory cells at the lesion site.	Curcumin	0-8	interleukin 1 beta	Mus musculus	110-118
24504121-3	2014	Here, we have found that long-time N-acetyl-L-cysteine treatment at low-concentration increases phosphorylation of extracellular signal-regulated kinase 1/2 and AKT, which are essential for the induction of proinflammatory cytokines including interleukin 1beta and interleukin 6 in lipopolysaccharide-stimulated RAW264.7 cells.	Acetylcysteine	35-54	interleukin 1 beta	Mus musculus	243-260
24498418-9	2014	CONCLUSION: Taken together, these results indicated that ethyl pyruvate protected against Con A-induced autoimmune hepatitis by decreasing both early (TNF-alpha, IL-2, IL-1beta and IL-6) and late (HMGB1) cytokine expression in mice.	ethyl pyruvate	57-71	interleukin 1 beta	Mus musculus	168-176
23938462-5	2014	The cascade involved prostaglandin E2 (PGE2) production from melanoma induced by IL-18-dependent tumor necrosis factor-alpha (TNFalpha); next, PGE2-induced IL-1beta via vascular endothelial growth factor (VEGF) secretion, which in turn induced VLA-4 activation via cyclooxygenase 2-dependent H2O2.	Dinoprostone	143-147	interleukin 1 beta	Mus musculus	156-164
24256503-2	2014	METHODS AND RESULTS: In the present study, we found that oxygen-glucose deprivation (OGD) resulted in BV-2 cells activation, significantly increased tumor necrosis factor-alpha and interleukin-1beta (IL-1beta) levels, accompanied by downregulating Kir6.1 subunit.	oxygen-glucose	57-71	interleukin 1 beta	Mus musculus	181-198
24256503-2	2014	METHODS AND RESULTS: In the present study, we found that oxygen-glucose deprivation (OGD) resulted in BV-2 cells activation, significantly increased tumor necrosis factor-alpha and interleukin-1beta (IL-1beta) levels, accompanied by downregulating Kir6.1 subunit.	oxygen-glucose	57-71	interleukin 1 beta	Mus musculus	200-208
24256503-5	2014	Pretreatment with nicorandil could reverse the two pathways involved in IL-1beta production.	Nicorandil	18-28	interleukin 1 beta	Mus musculus	72-80
24296134-3	2014	Although no significant cytotoxicity of PL was observed over the concentration range tested, PL (2.5-7.5 muM) significantly and dose-dependently suppressed the secretion of pro-inflammatory mediators and inhibited the expression of TNF-alpha, IL-1beta, IL-6 and iNOS in LPS-stimulated RAW 264.7 cells.	plumbagin	93-95	interleukin 1 beta	Mus musculus	243-251
24389380-4	2014	GB at doses of 300 and 600 mug/ml significantly inhibited the CS-induced increases in the mRNA and protein expression levels of interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, monocyte chemotactic protein (MCP)-1 and transforming growth factor (TGF)-beta1 in lung tissues and the BALF.	Glycopyrrolate	0-2	interleukin 1 beta	Mus musculus	128-150
24389380-4	2014	GB at doses of 300 and 600 mug/ml significantly inhibited the CS-induced increases in the mRNA and protein expression levels of interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, monocyte chemotactic protein (MCP)-1 and transforming growth factor (TGF)-beta1 in lung tissues and the BALF.	Cesium	62-64	interleukin 1 beta	Mus musculus	128-150
24140862-5	2014	In vitro, confocal microscopy and size-exclusion chromatography demonstrated that dismutation of O2(-) by 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (Tempol) and decomposition of H2O2 by catalase prevented Hcys-induced aggregation of NLRP3 inflammasome proteins and inhibited Hcys-induced caspase-1 activation and IL-1beta production in mouse podocytes.	Superoxides	97-99	interleukin 1 beta	Mus musculus	318-326
24140862-5	2014	In vitro, confocal microscopy and size-exclusion chromatography demonstrated that dismutation of O2(-) by 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (Tempol) and decomposition of H2O2 by catalase prevented Hcys-induced aggregation of NLRP3 inflammasome proteins and inhibited Hcys-induced caspase-1 activation and IL-1beta production in mouse podocytes.	tempol	154-160	interleukin 1 beta	Mus musculus	318-326
24286370-7	2014	Further studies revealed that taraxasterol significantly reduced TNF-alpha, IFN-gamma, IL-1beta, IL-6, NO and PGE2 levels in sera from mice with endotoxic shock.	taraxasterol	30-42	interleukin 1 beta	Mus musculus	87-95
24286371-4	2014	Real-time polymerase chain reaction showed that the mRNA levels of IL-17A, IL-17F, IL-22, IL-1beta, IL-6 and TNF-alpha in ear skin were significantly decreased by clobetasol.	Clobetasol	163-173	interleukin 1 beta	Mus musculus	90-98
23938462-5	2014	The cascade involved prostaglandin E2 (PGE2) production from melanoma induced by IL-18-dependent tumor necrosis factor-alpha (TNFalpha); next, PGE2-induced IL-1beta via vascular endothelial growth factor (VEGF) secretion, which in turn induced VLA-4 activation via cyclooxygenase 2-dependent H2O2.	Hydrogen Peroxide	292-296	interleukin 1 beta	Mus musculus	156-164
24363427-0	2014	IL-1beta and TLR4 signaling are involved in the aggravated murine acute graft-versus-host disease caused by delayed bortezomib administration.	Bortezomib	116-126	interleukin 1 beta	Mus musculus	0-8
24084689-8	2014	Isoflurane significantly inhibited both brain injury (P&lt;0.001, respectively) and inflammation (myeloperoxidase, P=0.022; interleukin-1beta, P=0.002; TNF-alpha, P=0.015; P-selectin, P=0.010; ICAM-1, P=0.016; p-JNK, P&lt;0.001; cyclooxygenase-2, P=0.003, respectively).	Isoflurane	0-10	interleukin 1 beta	Mus musculus	124-141
24363427-5	2014	Bortezomib treatment after dendritic cell (DC) activation resulted in drastically elevated IL-1beta production, whereas bortezomib treatment before DC activation inhibited IL-1beta production, suggesting that the timing of bortezomib administration significantly affected IL-1beta production by DCs.	Bortezomib	0-10	interleukin 1 beta	Mus musculus	91-99
24363427-5	2014	Bortezomib treatment after dendritic cell (DC) activation resulted in drastically elevated IL-1beta production, whereas bortezomib treatment before DC activation inhibited IL-1beta production, suggesting that the timing of bortezomib administration significantly affected IL-1beta production by DCs.	Bortezomib	120-130	interleukin 1 beta	Mus musculus	172-180
24363427-5	2014	Bortezomib treatment after dendritic cell (DC) activation resulted in drastically elevated IL-1beta production, whereas bortezomib treatment before DC activation inhibited IL-1beta production, suggesting that the timing of bortezomib administration significantly affected IL-1beta production by DCs.	Bortezomib	120-130	interleukin 1 beta	Mus musculus	172-180
24363427-8	2014	Our studies suggested that TLR4 pathway activation and delayed bortezomib administration amplified the production of IL-1beta and other inflammatory cytokines, which resulted in accelerated aGVHD-dependent morbidity.	Bortezomib	63-73	interleukin 1 beta	Mus musculus	117-125
24363427-9	2014	These results indicated that decreased toxicity of continuous bortezomib administration could be achieved by reduced-intensity conditioning or by inhibiting IL-1beta.	Bortezomib	62-72	interleukin 1 beta	Mus musculus	157-165
24634601-5	2014	CG also inhibited LPS-induced secretion of pro-inflammatory cytokines, IL-1beta and TNF-alpha.	cg	0-2	interleukin 1 beta	Mus musculus	71-79
24337047-5	2014	The results showed that following supplementation with EPS, interleukin (IL) 6, IL1beta and tumor necrosis factor (TNF) alpha mRNA expression in VAT were significantly reduced, while Glut4, pAMPK and SirT1 protein expression were markedly increased when compared with KKAy mice gavaged with water.	exophthalmos producing substance	55-58	interleukin 1 beta	Mus musculus	80-87
24475307-3	2014	We first demonstrated that extracellular ATP (2.5 mM) markedly increased the formation and activation of Nlrp3 inflammasomes in bone marrow macrophages (BMMs) from wild type (Asc+/+) mice resulting in activation of caspase-1 and IL-1beta production.	Adenosine Triphosphate	41-44	interleukin 1 beta	Mus musculus	229-237
24434415-12	2014	Moreover, GLN reduced IL-17A, IL-1beta, and IL-23 concentrations and myeloperoxidase activity in lung tissues.	Glutamine	10-13	interleukin 1 beta	Mus musculus	30-38
24395802-6	2014	Neutrophils, but not bone marrow-derived macrophages, from cmo mice secreted increased IL-1beta in response to ATP, silica, and Pseudomonas aeruginosa compared with neutrophils from WT mice.	Adenosine Triphosphate	111-114	interleukin 1 beta	Mus musculus	87-95
24465509-6	2014	Mice treated with DSCG had significantly reduced levels of the inflammatory cytokines IL-1alpha, IL-1beta, and CXCL1.	Cromolyn Sodium	18-22	interleukin 1 beta	Mus musculus	97-105
24395802-6	2014	Neutrophils, but not bone marrow-derived macrophages, from cmo mice secreted increased IL-1beta in response to ATP, silica, and Pseudomonas aeruginosa compared with neutrophils from WT mice.	Silicon Dioxide	116-122	interleukin 1 beta	Mus musculus	87-95
24239641-6	2014	In the peritonitis model, carvacryl acetate significantly decreased total and differential leukocyte counts, and reduced levels of myeloperoxidase and interleukin-1 beta (IL-1beta) in the peritoneal exudate.	carvacryl acetate	26-43	interleukin 1 beta	Mus musculus	151-169
24269960-5	2014	Moreover, curcumol inhibits LPS-induced production of TNF-alpha, IL-1beta and IL-6 at both the transcriptional and translational levels.	curcumol	10-18	interleukin 1 beta	Mus musculus	65-73
24454930-6	2014	The data indicated that the stimulation of J774 cells with LPS and ATP induces the features of pyroptosis, including the expression of IL-1beta mRNA and protein, activation of caspase-1, inflammasome formation and cell death.	Adenosine Triphosphate	67-70	interleukin 1 beta	Mus musculus	135-143
24454930-7	2014	Moreover, LL-37 inhibits the LPS/ATP-induced IL-1beta expression, caspase-1 activation, inflammasome formation, as well as cell death.	Adenosine Triphosphate	33-36	interleukin 1 beta	Mus musculus	45-53
24239641-6	2014	In the peritonitis model, carvacryl acetate significantly decreased total and differential leukocyte counts, and reduced levels of myeloperoxidase and interleukin-1 beta (IL-1beta) in the peritoneal exudate.	carvacryl acetate	26-43	interleukin 1 beta	Mus musculus	171-179
24186874-8	2014	IL-1beta suppressed the production of SP-B and pro-SP-C and decreased the amount of phosphatidylcholine and the percentage of palmitic acid in the phosphatidylcholine fraction of lung phospholipids, indicating that IL-1beta prevented the differentiation of type II epithelial cells.	Phosphatidylcholines	84-103	interleukin 1 beta	Mus musculus	0-8
24177262-12	2014	Correspondingly, folic acid significantly attenuated LPS-induced tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in placentas, maternal serum and amniotic fluid.	Folic Acid	17-27	interleukin 1 beta	Mus musculus	100-122
24141567-9	2014	Pretreatment of hCysLT1R-BV2 cells with the selective CysLT1R antagonist montelukast (1 mumol/L) significantly blocked LTD4-induced phagocytosis as well as the mRNA expression and release of IL-1beta, whereas the selective CysLT2R antagonist HAMI 3379 (1 mumol/L) had no such effects.	montelukast	73-84	interleukin 1 beta	Mus musculus	191-199
24186874-8	2014	IL-1beta suppressed the production of SP-B and pro-SP-C and decreased the amount of phosphatidylcholine and the percentage of palmitic acid in the phosphatidylcholine fraction of lung phospholipids, indicating that IL-1beta prevented the differentiation of type II epithelial cells.	Phosphatidylcholines	84-103	interleukin 1 beta	Mus musculus	215-223
24186874-8	2014	IL-1beta suppressed the production of SP-B and pro-SP-C and decreased the amount of phosphatidylcholine and the percentage of palmitic acid in the phosphatidylcholine fraction of lung phospholipids, indicating that IL-1beta prevented the differentiation of type II epithelial cells.	Palmitic Acid	126-139	interleukin 1 beta	Mus musculus	0-8
24186874-8	2014	IL-1beta suppressed the production of SP-B and pro-SP-C and decreased the amount of phosphatidylcholine and the percentage of palmitic acid in the phosphatidylcholine fraction of lung phospholipids, indicating that IL-1beta prevented the differentiation of type II epithelial cells.	Phosphatidylcholines	147-166	interleukin 1 beta	Mus musculus	0-8
24186874-8	2014	IL-1beta suppressed the production of SP-B and pro-SP-C and decreased the amount of phosphatidylcholine and the percentage of palmitic acid in the phosphatidylcholine fraction of lung phospholipids, indicating that IL-1beta prevented the differentiation of type II epithelial cells.	Phosphatidylcholines	147-166	interleukin 1 beta	Mus musculus	215-223
24186874-8	2014	IL-1beta suppressed the production of SP-B and pro-SP-C and decreased the amount of phosphatidylcholine and the percentage of palmitic acid in the phosphatidylcholine fraction of lung phospholipids, indicating that IL-1beta prevented the differentiation of type II epithelial cells.	Phospholipids	184-197	interleukin 1 beta	Mus musculus	0-8
24186874-8	2014	IL-1beta suppressed the production of SP-B and pro-SP-C and decreased the amount of phosphatidylcholine and the percentage of palmitic acid in the phosphatidylcholine fraction of lung phospholipids, indicating that IL-1beta prevented the differentiation of type II epithelial cells.	Phospholipids	184-197	interleukin 1 beta	Mus musculus	215-223
25003119-5	2014	Treatment with 40 mg/kg 4HCH reduced systolic hypertension, serum IL-1beta, and TNF-alpha levels and suppressed the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and renal injury.	4-hydroxychalcone	24-28	interleukin 1 beta	Mus musculus	66-74
24583856-0	2014	Caffeic acid reduces cutaneous tumor necrosis factor alpha (TNF-alpha), IL-6 and IL-1beta levels and ameliorates skin edema in acute and chronic model of cutaneous inflammation in mice.	caffeic acid	0-12	interleukin 1 beta	Mus musculus	81-89
24433504-16	2014	Compared with DEX positive medicine control, anti-IL-1beta scfv/TNFRI appeared more beneficial in treatment of CIA mice.	Dextromethorphan	14-17	interleukin 1 beta	Mus musculus	50-58
24596616-5	2014	Methyl p-hydroxycinnamate also suppressed LPS-induced overproduction of pro-inflammatory cytokines such as IL-1beta and TNF-alpha.	protocatechuic acid methyl ester	0-25	interleukin 1 beta	Mus musculus	107-115
24596617-4	2014	alpha-Asarone significantly reduced TNF-alpha and IL-1beta mRNA at 4 and 24 hours after the LPS injection at dose of 30 mg/kg.	asarone	0-13	interleukin 1 beta	Mus musculus	50-58
24985584-10	2014	Heparin markedly decreased both IL-1alpha and IL-1beta expression in the spleens and serum of burned mice.	Heparin	0-7	interleukin 1 beta	Mus musculus	46-54
24801214-5	2014	Here, we demonstrate that geniposide treatment significantly blocks Abeta-induced RAGE-dependent signaling (activation of ERK and NF-kappaB) along with the production of TNF-alpha and IL-1beta in cultured BV2 microglia cells.	geniposide	26-36	interleukin 1 beta	Mus musculus	184-192
24723958-3	2014	The lipopolysaccharide- (LPS-) induced IL-1 beta expression was significantly reduced when HASMCs were pretreated with EORP by Western blot and immunofluorescent staining.	hasmcs	91-97	interleukin 1 beta	Mus musculus	39-48
23771791-5	2014	RESULTS: D-galactose treatment, generally similar to NA, increased the lung pro-inflammatory status, as shown in the IL-6 and IL-1beta levels and the expression of phospho-Jun and phospho-JNK, and the fibrotic status as shown in the hydroxyproline level compared to the vehicle.	Galactose	9-20	interleukin 1 beta	Mus musculus	126-134
24772178-7	2014	DHI inhibited the elevations of hepatic lipid peroxidation (malondialdehyde), caspase-8 activity, and mRNA expression levels of inflammatory cytokines (interleukin-1 beta and interleukin-6) increased by D-GalN/LPS in the liver.	dehydrosoyasaponin I	0-3	interleukin 1 beta	Mus musculus	152-170
25668943-1	2014	It was established in experiments on noninbred mice that activation of alpha-7n acetylcholine receptors (alpha-7n AChR) by anabasine in single doses of 1.0 and 5.0 mg/kg for 2 h before modeling sepsis (intraperitoneal injection of E. coli) cause a significant dose-dependent reduction of mortality of mice due to a decrease in the amount of proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6 in the blood.	Anabasine	123-132	interleukin 1 beta	Mus musculus	378-386
24744815-7	2014	EAFA also suppressed the expression of IL-1 beta and IL-6, whereas it elevates the level of heme oxygenase-1.	eafa	0-4	interleukin 1 beta	Mus musculus	39-48
24660015-0	2014	Effects of Selenium-Enriched Protein from Ganoderma lucidum on the Levels of IL-1 beta and TNF- alpha , Oxidative Stress, and NF- kappa B Activation in Ovalbumin-Induced Asthmatic Mice.	Selenium	11-19	interleukin 1 beta	Mus musculus	77-86
24883066-6	2014	We investigated that EA significantly attenuated the I/R-induced upregulation of both Egr-1 and phosporylated-ERK1/2 (p-ERK1/2), decreased myocardial inflammatory cytokines including tumor necrosis factor- alpha (TNF- alpha ) and interleukin-1 beta (IL-1 beta ), and reduced the infarct size and the release of cardiac troponin I (cTnI).	Iodine	53-54	interleukin 1 beta	Mus musculus	230-248
24883066-6	2014	We investigated that EA significantly attenuated the I/R-induced upregulation of both Egr-1 and phosporylated-ERK1/2 (p-ERK1/2), decreased myocardial inflammatory cytokines including tumor necrosis factor- alpha (TNF- alpha ) and interleukin-1 beta (IL-1 beta ), and reduced the infarct size and the release of cardiac troponin I (cTnI).	Iodine	53-54	interleukin 1 beta	Mus musculus	250-259
25276218-3	2014	AC-mix potently suppressed DSS-induced body weight loss, colon shortening, myeloperoxidase activity, and TNF-alpha, IL-1beta, and IL-6 expressions in acute or chronic DSS-stimulated colitic mice.	ac-mix	0-6	interleukin 1 beta	Mus musculus	116-124
25276218-4	2014	Among AC-mix ingredients, AA, CC, and their main constituents mangiferin and berberine potently inhibited the expression of proinflammatory cytokines TNF-alpha and IL-1beta, as well as the activation of NF-kappaB in LPS-stimulated peritoneal macrophages.	Berberine	77-86	interleukin 1 beta	Mus musculus	164-172
25383082-4	2014	The results showed that in vitro propolis flavonoids liposome can significantly enhance the phagocytic function of macrophages and the release of IL-1beta, IL-6, and IFN-gamma.	Flavonoids	42-52	interleukin 1 beta	Mus musculus	146-154
24127072-8	2014	Chlorogenic acid also attenuated pro-inflammatory cytokines (including IL-1beta and TNF-alpha) and other inflammation-related markers such as IL-6 in a dose-dependent manner.	Chlorogenic Acid	0-16	interleukin 1 beta	Mus musculus	71-79
25175869-10	2014	Alcohol-induced IL-1beta secretion also requires Nod-like receptor-mediated inflammasome and caspase-1 activation, and, consistent with this, disruption of IL-1/IL-1-receptor signaling prevents alcohol-induced neuroinflammation.	Alcohols	0-7	interleukin 1 beta	Mus musculus	16-24
25175869-10	2014	Alcohol-induced IL-1beta secretion also requires Nod-like receptor-mediated inflammasome and caspase-1 activation, and, consistent with this, disruption of IL-1/IL-1-receptor signaling prevents alcohol-induced neuroinflammation.	Alcohols	194-201	interleukin 1 beta	Mus musculus	16-24
24883066-6	2014	We investigated that EA significantly attenuated the I/R-induced upregulation of both Egr-1 and phosporylated-ERK1/2 (p-ERK1/2), decreased myocardial inflammatory cytokines including tumor necrosis factor- alpha (TNF- alpha ) and interleukin-1 beta (IL-1 beta ), and reduced the infarct size and the release of cardiac troponin I (cTnI).	r	55-56	interleukin 1 beta	Mus musculus	230-248
24883066-6	2014	We investigated that EA significantly attenuated the I/R-induced upregulation of both Egr-1 and phosporylated-ERK1/2 (p-ERK1/2), decreased myocardial inflammatory cytokines including tumor necrosis factor- alpha (TNF- alpha ) and interleukin-1 beta (IL-1 beta ), and reduced the infarct size and the release of cardiac troponin I (cTnI).	r	55-56	interleukin 1 beta	Mus musculus	250-259
23697399-4	2014	The results showed that there was a lower production of TNFalpha, IL-6, and IL-1beta in the serum of LPS-challenged mice that had been pre-treated with pinocembrin.	pinocembrin	152-163	interleukin 1 beta	Mus musculus	76-84
24161429-17	2014	Moreover, dexamethasone (0.5mg/kg, i.p., used as a positive control) inhibited inflammatory cell infiltration and reduced the levels of TNF-alpha, IL-1beta and IL-6 in LPS-injected mice.	Dexamethasone	10-23	interleukin 1 beta	Mus musculus	147-155
23999228-0	2014	The effects of early life Pb exposure on the expression of IL1-beta, TNF-alpha and Abeta in cerebral cortex of mouse pups.	Lead	26-28	interleukin 1 beta	Mus musculus	59-67
25054161-4	2014	Silica increased NLRP3 inflammasome activation and release of the proinflammatory cytokine, IL-1beta, to a greater extent in MARCO(-/-) AM compared to wild type (WT) AM.	Silicon Dioxide	0-6	interleukin 1 beta	Mus musculus	92-100
24138316-6	2014	alpha-Iso-cubebenol also suppressed the production of tumour necrosis factor-alpha, IL-1beta, IL-6, monocyte chemoattractant protein-1 and reactive oxygen species in a dose-dependent manner, while decreasing the nuclear translocation and transactivity of NF-kappaB by inhibiting the phosphorylation and degradation of the inhibitor of kappaB (IkappaB)alpha.	alpha-iso-cubebenol	0-19	interleukin 1 beta	Mus musculus	84-92
23999228-1	2014	OBJECTIVE: To investigate the effects of maternal lead (Pb) exposure on the learning and memory ability and expression of interleukin1-beta (IL1-beta), tumor necrosis factor (TNF-alpha) and beta amyloid protein (Abeta) in cerebral cortex of mice offspring.	Lead	56-58	interleukin 1 beta	Mus musculus	122-139
23999228-1	2014	OBJECTIVE: To investigate the effects of maternal lead (Pb) exposure on the learning and memory ability and expression of interleukin1-beta (IL1-beta), tumor necrosis factor (TNF-alpha) and beta amyloid protein (Abeta) in cerebral cortex of mice offspring.	Lead	56-58	interleukin 1 beta	Mus musculus	141-149
23999228-8	2014	The expression of IL1-beta, TNF-alpha and Abeta was increased in Pb exposed groups than that of the control group (P&lt;0.05).	Lead	65-67	interleukin 1 beta	Mus musculus	18-26
25392278-0	2014	Role of tumor necrosis factor-alpha and interleukin-1beta in anorexia induction following oral exposure to the trichothecene deoxynivalenol (vomitoxin) in the mouse.	deoxynivalenol	125-139	interleukin 1 beta	Mus musculus	40-57
23999228-9	2014	CONCLUSIONS: The high expression of IL1-beta, TNF-alpha and Abeta in the cerebral cortex of pups may contribute to the impairment of learning and memory associated with maternal Pb exposure.	Lead	178-180	interleukin 1 beta	Mus musculus	36-44
25392278-3	2014	The purpose of this research was to determine the role of two proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in DON-induced anorexia.	deoxynivalenol	165-168	interleukin 1 beta	Mus musculus	133-150
25392278-3	2014	The purpose of this research was to determine the role of two proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in DON-induced anorexia.	deoxynivalenol	165-168	interleukin 1 beta	Mus musculus	152-160
24623963-6	2014	Similarly, LPS-stimulated IL-1 beta release from whole blood was significantly enhanced in ethanol-fed mice.	Ethanol	91-98	interleukin 1 beta	Mus musculus	26-35
25392278-6	2014	Oral exposure to DON at 5 mg/kg bw stimulated splenic and hepatic mRNA and plasma protein elevations of TNF-alpha and IL-1beta that corresponded to anorexia induction.	deoxynivalenol	17-20	interleukin 1 beta	Mus musculus	118-126
25392278-9	2014	Taken together, the results suggest that both TNF-alpha and IL-1beta play contributory role in anorexia induction following oral exposure to DON.	deoxynivalenol	141-144	interleukin 1 beta	Mus musculus	60-68
24185109-10	2014	In vitro, boswellic acid was able to inhibit IL-1beta and TLR4 mediated induction of several inflammatory mediators from OA synovial explant tissue.	boswellic acid	10-24	interleukin 1 beta	Mus musculus	45-53
24550603-3	2014	The injection of carrageenan into the pleural cavity induced the accumulation of fluid containing a large number of polymorphonuclear cells (PMNs) as well as infiltration of PMNs in lung tissues and increased production of nitrite and tumor necrosis factor-alpha and increased expression of interleukin-1beta, cyclooxygenase (COX-2), and inducible nitric oxide synthase.	Carrageenan	17-28	interleukin 1 beta	Mus musculus	291-308
24189446-8	2014	Donepezil significantly attenuated the release of inflammatory mediators (prostaglandin E2, interleukin-1 beta, tumor necrosis factor-alpha, and nitric oxide) from microglia.	Donepezil	0-9	interleukin 1 beta	Mus musculus	92-139
24803746-4	2014	The results showed that BHBA significantly reduced LPS-induced protein and mRNA expression levels of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6.	3-Hydroxybutyric Acid	24-28	interleukin 1 beta	Mus musculus	125-133
25147439-6	2014	Treatment with palmitoleate markedly attenuated the insulin resistance induced by the HFD, increased glucose uptake and incorporation into muscle in vitro, reduced the serum levels of AST in WT mice, decreased the hepatic levels of IL1-beta and IL-12 in KO mice, reduced the expression of TLR-4 and increased the expression of IL-1Ra in WT mice, and reduced the phosphorylation of NF     B (p65) in the livers of KO mice.	palmitoleic acid	15-27	interleukin 1 beta	Mus musculus	232-240
23983093-3	2014	According to the results, both MEFA and MELA decreased the intensity of leukocyte infiltration in mouse dorsal skin and cutaneous edema induced by TPA, which appeared to be mediated by inhibition of proinflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6) and proinflammatory mediators (TNF-alpha, IL-1beta, and Prostaglandin E2 ).	Tetradecanoylphorbol Acetate	147-150	interleukin 1 beta	Mus musculus	322-330
23983093-3	2014	According to the results, both MEFA and MELA decreased the intensity of leukocyte infiltration in mouse dorsal skin and cutaneous edema induced by TPA, which appeared to be mediated by inhibition of proinflammatory genes (inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, and IL-6) and proinflammatory mediators (TNF-alpha, IL-1beta, and Prostaglandin E2 ).	Tetradecanoylphorbol Acetate	147-150	interleukin 1 beta	Mus musculus	384-392
24364787-6	2014	Thus, findings of the present study suggest that the chemopreventive effect of silibinin is associated with upregulation of endogenous cytoprotective machinery and down regulation of inflammatory mediators (nitric oxide, tumor necrosis factor-alpha, interleukin-6, interleukin -1beta, COX-2, iNOS, and NF-kappaB).	Silybin	79-88	interleukin 1 beta	Mus musculus	265-283
24724468-3	2014	The objective of this study was to determine the effect of commercial nanocolloids of noble metals (silver, gold and copper), recommended by the manufacturer as dietary supplements, on the in vitro viability, proliferative activity and production of cytokines (IL-1beta, IL-2, IL-6, IL-10 and TNF-alpha) by mouse splenocytes.	Copper	117-123	interleukin 1 beta	Mus musculus	261-269
25147596-5	2014	ISO also reduced the production of tumor necrosis factor-alpha, interleukin-1beta, IL-6, high-mobility group box-1, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-2, and monocyte chemoattractant protein-1 as assessed by enzyme-linked immunosorbent assays.	Isoflurane	0-3	interleukin 1 beta	Mus musculus	64-81
24177139-6	2014	RESULTS: Serum amylase, lipase, nitrite, TNF-alpha, and IL-1beta, and pancreatic and lung MPO were increased in both taurolithocholic acid sulfate and cerulein acute pancreatitis compared with the respective control groups.	taurolithocholic acid 3-sulfate	117-146	interleukin 1 beta	Mus musculus	56-64
24201778-9	2014	Serum levels of interleukin 1beta, interferon-gamma, and tumor necrosis factor alpha were elevated in the AL+LPS-treated mice.	Aluminum	106-108	interleukin 1 beta	Mus musculus	16-33
25171128-5	2014	Moreover, beta-caryophyllene reduced astrogliosis and microglial activation as well as the levels of COX-2 protein and the mRNA levels of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in the cerebral cortex.	caryophyllene	10-28	interleukin 1 beta	Mus musculus	200-217
24724468-8	2014	At the same time, copper colloid alone induced the synthesis of IL-1beta in mitogen unstimulated cells.	Copper	18-24	interleukin 1 beta	Mus musculus	64-72
24367694-4	2013	We found that PLMs activate caspase-1 in murine macrophage cell line J774 independent of the glycan chain length although IL-1beta secretion is more intense with long glycan chain.	Polysaccharides	167-173	interleukin 1 beta	Mus musculus	122-130
24211274-7	2014	There was a significant increase in the levels of T cell cytokines IL-2, IL-1beta, and IFN-gamma in bromodichloromethane exposed DIO mice but not in mice that lacked CYP2E1, leptin or T and B cells.	bromodichloromethane	100-120	interleukin 1 beta	Mus musculus	73-81
24405591-0	2014	[Inhibition of Fasudil on lipopolysaccharide-induced TNF-alpha and IL-1beta expressions through TLR4 pathway in murine BV-2 cells in vitro].	fasudil	15-22	interleukin 1 beta	Mus musculus	67-75
24405591-7	2014	Fasudil attenuated NO production, and reduced the release of TNF-alpha and IL-1beta in LPS-stimulated BV-2 cells.	fasudil	0-7	interleukin 1 beta	Mus musculus	75-83
24405591-9	2014	CONCLUSION: Fasudil can suppress the production of TNF-alpha, IL-1beta and NO of microglia cells induced by LPS, which may be associated with the down-regulation of TLR4 pathway.	fasudil	12-19	interleukin 1 beta	Mus musculus	62-70
24351869-10	2013	Further study revealed that 4-MCPC treatment also decreased IL-1beta, TNF-alpha, PGE2 and MPO levels in mice paws.	4-methylcyclopentadecanone	28-34	interleukin 1 beta	Mus musculus	60-68
24349164-8	2013	The aqueous seed extract, cmol and WSMoL (6.25 microg/mL) and diluted seed extract at 50 microg/mL exhibited anti-inflammatory activity on lipopolyssaccharide-stimulated murine macrophages by regulating the production of nitric oxide, TNF-alpha and IL-1beta.	lipopolyssaccharide	139-158	interleukin 1 beta	Mus musculus	249-257
24269819-3	2013	Intravenous treatment with HS-23 rescued LPS-intoxicated C57BL/6J mice under septic conditions, and decreased the levels of cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta and high-mobility group box-1 (HMGB-1) in the blood.	hs-23	27-32	interleukin 1 beta	Mus musculus	183-205
24349401-9	2013	In the mouse experiments, LPS was injected intraperitoneally, and isoflurane suppressed IL-1beta in the brain and adrenocorticotropic hormone in plasma, but not IL-1beta in plasma.	Isoflurane	66-76	interleukin 1 beta	Mus musculus	88-96
24351869-12	2013	Taken together, our results suggest that 4-MCPC has potent anti-inflammatory activity and the mechanisms might be related to the decreases of the levels of IL-1beta, TNF-alpha, PGE2 and MPO in inflamed paws.	4-methylcyclopentadecanone	41-47	interleukin 1 beta	Mus musculus	156-164
24324578-6	2013	Treatment with KB3495 was also associated with a reduction of macrophage content in the atherosclerotic plaques and reduced serum levels of IL-1beta, TNFalpha, IL-6, Interferon gamma, MCP-1 and M-CSF.	kb3495	15-21	interleukin 1 beta	Mus musculus	140-148
24056124-2	2013	Tunicamycin caused a reduction in LPS-induced nitric oxide (NO) production and expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha).	Tunicamycin	0-11	interleukin 1 beta	Mus musculus	149-167
24056124-2	2013	Tunicamycin caused a reduction in LPS-induced nitric oxide (NO) production and expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1 beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha).	Tunicamycin	0-11	interleukin 1 beta	Mus musculus	169-177
24051194-3	2013	DADS decreased nitric oxide production with a reduction in the levels of interleukins (IL)-1beta and IL-6 in RAW264.7 cells stimulated with LPS.	diallyl disulfide	0-4	interleukin 1 beta	Mus musculus	73-96
23938198-6	2013	When injected subcutaneously in mice, calcium alginate gels significantly upregulated IL-1beta secretion from surrounding tissue relative to barium alginate gels, and similarly, the inflammatory effects of LPS were enhanced when it was delivered from calcium alginate gels rather than barium alginate gels.	Alginates	38-54	interleukin 1 beta	Mus musculus	86-94
24324059-8	2013	In vitro, LPS-activated macrophages treated with 14,15-EET showed a significant reduction of LPS-triggered IL-1beta and TNF-alpha expression.	15-eet	52-58	interleukin 1 beta	Mus musculus	107-115
23994089-4	2013	Tyrosol significantly attenuated TNF-alpha, IL-1beta and IL-6 production in serum from mice challenged with LPS, and consistent with the results in vitro.	4-hydroxyphenylethanol	0-7	interleukin 1 beta	Mus musculus	44-52
24312491-7	2013	Microscopy showed reduced damage in Nlrp3(-/-) mice, and increased severity of disease in WT mice with IL-1beta treatments, in particular on 10 DPI.	3-aminodiphenyleneiodium	144-147	interleukin 1 beta	Mus musculus	103-111
24022661-8	2013	Blockade of P2X7 activation by BBG suppressed NLRP3/ASC/caspase 1 assembly and the subsequent release of interleukin-1beta (IL-1beta), resulting in a significant reduction in the severity of nephritis and circulating anti-dsDNA antibodies.	coomassie Brilliant Blue	31-34	interleukin 1 beta	Mus musculus	105-122
24022661-8	2013	Blockade of P2X7 activation by BBG suppressed NLRP3/ASC/caspase 1 assembly and the subsequent release of interleukin-1beta (IL-1beta), resulting in a significant reduction in the severity of nephritis and circulating anti-dsDNA antibodies.	coomassie Brilliant Blue	31-34	interleukin 1 beta	Mus musculus	124-132
24022661-10	2013	BBG treatment reduced the serum levels of IL-1beta and IL-17 and the Th17:Treg cell ratio.	coomassie Brilliant Blue	0-3	interleukin 1 beta	Mus musculus	42-50
24465142-0	2013	The Effect of Agmatine on Expression of IL-1beta and TLX Which Promotes Neuronal Differentiation in Lipopolysaccharide-Treated Neural Progenitors.	Agmatine	14-22	interleukin 1 beta	Mus musculus	40-48
24465142-3	2013	We aimed to investigate whether agmatine (Agm), a primary polyamine that protects neural cells, could trigger differentiation of NPCs by activating IL-1beta in vitro.	Agmatine	32-40	interleukin 1 beta	Mus musculus	148-156
24465142-3	2013	We aimed to investigate whether agmatine (Agm), a primary polyamine that protects neural cells, could trigger differentiation of NPCs by activating IL-1beta in vitro.	Agmatine	42-45	interleukin 1 beta	Mus musculus	148-156
24465142-9	2013	Differentiation of LPS-induced, Agm-treated NPCs was regulated by the MAPK pathway and is thought to be related to IL-1beta activation and decreased expression of TLX, a transcription factor that regulates NPC differentiation.	Agmatine	32-35	interleukin 1 beta	Mus musculus	115-123
24055769-4	2013	We found that AI and 6-OAAI inhibit the production of NO, iNOS, and pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1beta, and MCP-1) in LPS-stimulated RAW264.7 macrophages.	austroinulin	14-16	interleukin 1 beta	Mus musculus	113-121
24161485-5	2013	TMF inhibits the productions and mRNA expressions of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 induced by LPS.	5,6,7-trimethoxyflavone	0-3	interleukin 1 beta	Mus musculus	94-116
24161485-8	2013	Taken together, these findings suggest that TMF down-regulates the expressions of the pro-inflammatory iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 genes in macrophages by interfering with the activation of NF-kappaB, AP-1, and STAT1/3.	5,6,7-trimethoxyflavone	44-47	interleukin 1 beta	Mus musculus	127-135
24055769-4	2013	We found that AI and 6-OAAI inhibit the production of NO, iNOS, and pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1beta, and MCP-1) in LPS-stimulated RAW264.7 macrophages.	6-O-acetyl-austroinulin	21-27	interleukin 1 beta	Mus musculus	113-121
23994575-9	2013	Serum levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1beta increased after GalN/LPS treatment; these increases were attenuated by hemin.	Galactosamine	99-103	interleukin 1 beta	Mus musculus	60-82
23994575-10	2013	Hepatic mRNA levels of TNF-alpha, IL-1beta, and NLRP3 increased after GalN/LPS treatment, and hemin attenuated increases in TNF-alpha and IL-1beta.	Galactosamine	70-74	interleukin 1 beta	Mus musculus	34-42
23735482-6	2013	Quercetin inhibited LPS-induced NO, PGE2, iNOS, COX-2, TNF-alpha, IL-1beta, IL-6 and GM-CSF mRNA and protein expressions while it promoted HO-1 induction in a dose- and time-dependent manner.	Quercetin	0-9	interleukin 1 beta	Mus musculus	66-74
23703580-7	2013	In addition, GFT505 improved liver dysfunction markers, decreased hepatic lipid accumulation, and inhibited proinflammatory (interleukin-1 beta, tumor necrosis factor alpha, and F4/80) and profibrotic (transforming growth factor beta, tissue inhibitor of metalloproteinase 2, collagen type I, alpha 1, and collagen type I, alpha 2) gene expression.	2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acid	13-19	interleukin 1 beta	Mus musculus	125-172
24082061-8	2013	Indeed, diltiazem prevented the interleukin-6-induced mRNA expression of interleukin-1beta and the monocyte chemoattractant protein CCL12 in peritoneal macrophages and RAW264.7 cells independent of the intracellular calcium concentration.	Diltiazem	8-17	interleukin 1 beta	Mus musculus	73-90
23892998-5	2013	In lipopolysaccharide (LPS)-induced RAW264.7 cells, baicalein exerts anti-inflammatory effects by inhibiting iNOS, COX-2, and TNF-alpha mRNA expression; NO production; as well as inflammatory cytokine (IL-1beta, PGE2, and TNF-alpha) production through an ER-dependent pathway.	baicalein	52-61	interleukin 1 beta	Mus musculus	202-210
23959762-2	2013	When added to Raw 264.7 cells in combination with lipopolysaccharide, lovastatin significantly potentiated the release of interleukin-1beta, interleukin-6 and interleukin-12 with respect to lipopolysaccharide alone and showed an additive effect on the release of nitric oxide.	Lovastatin	70-80	interleukin 1 beta	Mus musculus	122-139
24008816-8	2013	Treatment with DHA also decreased anti-collagen (CII) antibodies in vivo, downregulated interleukin-1beta, interferongamma and upregulated protective interleukin-10 ex vivo.	Docosahexaenoic Acids	15-18	interleukin 1 beta	Mus musculus	88-105
23959762-3	2013	Similarly, when lovastatin was intraperitoneally administrated to BALB/c mice, it did not induce any pro-inflammatory effect when used alone, but it significantly potentiated the pro-inflammatory activity of lipopolysaccharide, in terms of number of intraperitoneal cells and serum levels of serum amyloid A, interleukin-1beta, interleukin-6 and interleukin-12.	Lovastatin	16-26	interleukin 1 beta	Mus musculus	309-326
24211200-9	2013	Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-kappaB) at lysine 310, resulting in reduced expression of NF-kappaB-dependent genes, including interleukin 1beta (IL-1beta), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13.	Lysine	86-92	interleukin 1 beta	Mus musculus	170-187
24294967-8	2013	Furthermore, DT3 significantly inhibited radiation-induced production of pro-inflammatory factors interleukin-1beta and -6 and suppressed expression of protein tyrosine kinase 6 (PTK6), a stress-induced kinase that promotes apoptosis in mouse intestinal cells.	dt3	13-16	interleukin 1 beta	Mus musculus	98-122
24321066-4	2013	RESULTS: Citalopram significantly inhibited the mRNA and protein expressions of TNF-alpha and IL-1beta, and the phosphorylation of p38MAPK and JNK.	Citalopram	9-19	interleukin 1 beta	Mus musculus	94-102
24321066-1	2013	OBJECTIVE: To investigate the effects of antidepressant citalopram on the gene expressions of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1beta), and to discuss the impacts of citalopram on p38 and c-jun N-terminal kinase (JNK) of mitogen-activated protein kinase (MAPK) family in microglial cells.	Citalopram	56-66	interleukin 1 beta	Mus musculus	138-156
24321066-1	2013	OBJECTIVE: To investigate the effects of antidepressant citalopram on the gene expressions of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1beta), and to discuss the impacts of citalopram on p38 and c-jun N-terminal kinase (JNK) of mitogen-activated protein kinase (MAPK) family in microglial cells.	Citalopram	56-66	interleukin 1 beta	Mus musculus	158-166
24211200-9	2013	Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-kappaB) at lysine 310, resulting in reduced expression of NF-kappaB-dependent genes, including interleukin 1beta (IL-1beta), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13.	Lysine	86-92	interleukin 1 beta	Mus musculus	189-197
24260470-5	2013	Our results show that quercetin significantly attenuates LPS-induced production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in RAW264.7 macrophages.	Quercetin	22-31	interleukin 1 beta	Mus musculus	127-144
24060409-10	2013	A further study revealed that EE, DA and MG (10, 20, 40mug/mL) exhibited stronger inhibitory effects on the production of pro-inflammatory cytokines (including interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha) in MSU crystals-treated RAW 264.7 cells.	doliroside A	34-36	interleukin 1 beta	Mus musculus	160-177
24060409-10	2013	A further study revealed that EE, DA and MG (10, 20, 40mug/mL) exhibited stronger inhibitory effects on the production of pro-inflammatory cytokines (including interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha) in MSU crystals-treated RAW 264.7 cells.	Magnesium	41-43	interleukin 1 beta	Mus musculus	160-177
24260470-5	2013	Our results show that quercetin significantly attenuates LPS-induced production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in RAW264.7 macrophages.	Quercetin	22-31	interleukin 1 beta	Mus musculus	146-154
24260470-8	2013	Most importantly, acute administration of quercetin reduces the lethality rate and circulating levels of TNF-alpha and IL-1beta in C57BL/6J mice with endotoxemia induced by LPS, whereas chronic dietary supplementation with quercetin shows no inhibitory effect on serum TNF-alpha and IL-1beta levels.	Quercetin	42-51	interleukin 1 beta	Mus musculus	119-127
24260470-8	2013	Most importantly, acute administration of quercetin reduces the lethality rate and circulating levels of TNF-alpha and IL-1beta in C57BL/6J mice with endotoxemia induced by LPS, whereas chronic dietary supplementation with quercetin shows no inhibitory effect on serum TNF-alpha and IL-1beta levels.	Quercetin	42-51	interleukin 1 beta	Mus musculus	283-291
24260470-8	2013	Most importantly, acute administration of quercetin reduces the lethality rate and circulating levels of TNF-alpha and IL-1beta in C57BL/6J mice with endotoxemia induced by LPS, whereas chronic dietary supplementation with quercetin shows no inhibitory effect on serum TNF-alpha and IL-1beta levels.	Quercetin	223-232	interleukin 1 beta	Mus musculus	283-291
23532958-2	2013	Here, we show that chronic plus binge ethanol feeding synergistically up-regulated the hepatic expression of interleukin-1beta and tumor necrosis factor alpha and induced neutrophil accumulation in the liver, compared with chronic or binge feeding alone.	Ethanol	38-45	interleukin 1 beta	Mus musculus	109-158
24045165-0	2013	Cladribine interferes with IL-1beta synaptic effects in experimental multiple sclerosis.	Cladribine	0-10	interleukin 1 beta	Mus musculus	27-35
24045165-4	2013	Cladribine failed to interfere with EAE-induced microglial and astroglial activation, but blocked EAE synaptic alterations by interfering with interleukin-1beta effects.	Cladribine	0-10	interleukin 1 beta	Mus musculus	143-160
24013028-6	2013	To address this hypothesis, we examined the effect of glucose on IL-1alpha and IL-1beta mRNA expression in the hypothalamus.	Glucose	54-61	interleukin 1 beta	Mus musculus	79-87
24013028-8	2013	Levels of IL-1alpha and IL-1beta mRNA in the hypothalamus were increased in response to feeding and intraperitoneal injection of glucose, and were positively correlated with blood glucose levels in mice.	Glucose	129-136	interleukin 1 beta	Mus musculus	24-32
24013028-8	2013	Levels of IL-1alpha and IL-1beta mRNA in the hypothalamus were increased in response to feeding and intraperitoneal injection of glucose, and were positively correlated with blood glucose levels in mice.	Glucose	180-187	interleukin 1 beta	Mus musculus	24-32
24013028-9	2013	Exposure of hypothalamic explants to high glucose (10 mM) media increased IL-1alpha and IL-1beta mRNA levels compared to low glucose (1 mM) media.	Glucose	42-49	interleukin 1 beta	Mus musculus	88-96
23941302-9	2013	Oral administration of PGG inhibited colon shortening and myeloperoxidase activity in mice with TNBS-induced colitis, along with reducing NF-kappaB activation and IL-1beta, TNF-alpha, and IL-6 levels, whereas it increased IL-10.	pgg	23-26	interleukin 1 beta	Mus musculus	163-171
23882124-3	2013	Treatment with 300 muM nicotinic acid (reported EC50 3 muM, peak plasma concentration 50-300 muM), significantly inhibited TNF-alpha, IL-6, IL-12p40, and IL-1beta production (P&lt;0.05) in LPS (1 ng/ml)-stimulated wild-type murine bone marrow-derived macrophages (BMMs) but failed to do so in Hca2(-/-) BMMs.	Niacin	23-37	interleukin 1 beta	Mus musculus	154-162
23912038-7	2013	Hcy treatment significantly increased malondialdehyde, nitrite level, acetylcholinestrase activity, tumor necrosis factor-alpha, interleukin-1 beta, glial fibrillary acidic protein, inducible nitric oxide synthase, endothelial nitric oxide synthase and decreased glutathione level indicating oxidative-nitrosative stress and neuroinflammation as compared to control and aCSF-treated groups.	Homocysteine	0-3	interleukin 1 beta	Mus musculus	129-147
23640035-0	2013	Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice.	Silicon Dioxide	48-54	interleukin 1 beta	Mus musculus	18-36
23640035-2	2013	Interleukin-1 beta (IL-1beta) plays an important role in silica-induced lung inflammation, but the mechanisms that underlie the influence of IL-1beta on the progression of silicosis remain unclear.	Silicon Dioxide	57-63	interleukin 1 beta	Mus musculus	0-18
23640035-2	2013	Interleukin-1 beta (IL-1beta) plays an important role in silica-induced lung inflammation, but the mechanisms that underlie the influence of IL-1beta on the progression of silicosis remain unclear.	Silicon Dioxide	57-63	interleukin 1 beta	Mus musculus	20-28
23640035-3	2013	In this study, the role of IL-1beta in silica-induced inflammation and fibrosis was evaluated by administering a suspension of 2.5-mg silica dust, either with or without 40 mug anti-mouse IL-1beta monoclonal antibody (mAb), to the lungs of male C57BL/6 mice.	Silicon Dioxide	39-45	interleukin 1 beta	Mus musculus	27-35
23640035-4	2013	Silica + anti-IL-1beta mAb-treated mice showed the depletion of IL-1beta as well as the attenuation of inflammation, as evaluated in the bronchoalveolar lavage fluid (BALF) and histological sections from 1 to 84 days after silica exposure.	Silicon Dioxide	0-6	interleukin 1 beta	Mus musculus	14-22
23640035-4	2013	Silica + anti-IL-1beta mAb-treated mice showed the depletion of IL-1beta as well as the attenuation of inflammation, as evaluated in the bronchoalveolar lavage fluid (BALF) and histological sections from 1 to 84 days after silica exposure.	Silicon Dioxide	0-6	interleukin 1 beta	Mus musculus	64-72
23640035-4	2013	Silica + anti-IL-1beta mAb-treated mice showed the depletion of IL-1beta as well as the attenuation of inflammation, as evaluated in the bronchoalveolar lavage fluid (BALF) and histological sections from 1 to 84 days after silica exposure.	Silicon Dioxide	223-229	interleukin 1 beta	Mus musculus	14-22
23640035-6	2013	The real-time PCR and pathology results showed that the neutralization of IL-1beta attenuated silica-induced fibrosis by inhibiting the gene expression of transforming growth factor-beta 1, collagen I and fibronectin.	Silicon Dioxide	94-100	interleukin 1 beta	Mus musculus	74-82
23640035-8	2013	In conclusion, the present study suggests that the neutralization of IL-1beta attenuates silica-induced inflammation and fibrosis by inhibiting other inflammatory and fibrogenic mediators and modulating the Th1/Th2 balance.	Silicon Dioxide	89-95	interleukin 1 beta	Mus musculus	69-77
23884544-6	2013	We show that palmitate affects the mRNA levels of the pro-inflammatory cytokines interleukin-1beta and interleukin-6.	Palmitates	13-22	interleukin 1 beta	Mus musculus	81-98
23929940-5	2013	In the acute phase after tamoxifen treatment, cell infiltration into the myocardium was accompanied by increased expression of pro-inflammatory cytokines (IL-1beta, IL-6, TNFalpha, IFNgamma, Ccl2) and markers of hypertrophy (ANF, BNP, Col3a1).	Tamoxifen	25-34	interleukin 1 beta	Mus musculus	155-163
23609920-2	2013	Meanwhile, cytokines, such as interleukin-1beta (IL-1beta), stimulate inducible nitric oxide synthase (iNOS) expression and nitric oxide overproduction leading to beta-cell damage.	Nitric Oxide	80-92	interleukin 1 beta	Mus musculus	30-47
23609920-2	2013	Meanwhile, cytokines, such as interleukin-1beta (IL-1beta), stimulate inducible nitric oxide synthase (iNOS) expression and nitric oxide overproduction leading to beta-cell damage.	Nitric Oxide	80-92	interleukin 1 beta	Mus musculus	49-57
23609920-8	2013	RESULTS: IL-1beta treatment (range, 5-40 ng/ml) for 24 h was positively correlated with nitrite production (R2=0.9668, p&lt;0.01), a significant increase in the percentage of apoptotic cells (p&lt;0.01) and a concomitant dose-dependent increase in cytoplasmic levels of iNOS and NF-kappaB p65 activation.	Nitrites	88-95	interleukin 1 beta	Mus musculus	9-17
24078693-2	2013	We found a heretofore unappreciated role for caspase-8 as a major pathway for IL-1beta processing and release in murine bone marrow-derived dendritic cells (BMDC) costimulated with TLR4 agonists and proapoptotic chemotherapeutic agents such as doxorubicin (Dox) or staurosporine (STS).	Doxorubicin	257-260	interleukin 1 beta	Mus musculus	78-86
24078693-2	2013	We found a heretofore unappreciated role for caspase-8 as a major pathway for IL-1beta processing and release in murine bone marrow-derived dendritic cells (BMDC) costimulated with TLR4 agonists and proapoptotic chemotherapeutic agents such as doxorubicin (Dox) or staurosporine (STS).	Staurosporine	265-278	interleukin 1 beta	Mus musculus	78-86
24078693-2	2013	We found a heretofore unappreciated role for caspase-8 as a major pathway for IL-1beta processing and release in murine bone marrow-derived dendritic cells (BMDC) costimulated with TLR4 agonists and proapoptotic chemotherapeutic agents such as doxorubicin (Dox) or staurosporine (STS).	Staurosporine	280-283	interleukin 1 beta	Mus musculus	78-86
24078693-3	2013	The ability of Dox to stimulate release of mature (17-kDa) IL-1beta was nearly equivalent in wild-type (WT) BMDC, Casp1(-/-)Casp11(-/-) BMDC, WT BMDC treated with the caspase-1 inhibitor YVAD, and BMDC lacking the inflammasome regulators ASC, NLRP3, or NLRC4.	Doxorubicin	15-18	interleukin 1 beta	Mus musculus	59-67
24078693-4	2013	Notably, Dox-induced production of mature IL-1beta was temporally correlated with caspase-8 activation in WT cells and greatly suppressed in Casp8(-/-)Rip3(-/-) or Trif(-/-) BMDC, as well as in WT BMDC treated with the caspase-8 inhibitor, IETD.	Doxorubicin	9-12	interleukin 1 beta	Mus musculus	42-50
23594088-10	2013	RESULTS: Compared with the control group, the glycyrrhizin group showed significantly improved neurologic outcome, reduced apoptosis of motoneurons of spinal anterior horn, decreased the activation of NF-kappaB and subsequent inflammatory cytokines expression [tumor necrosis factor (TNF) and interleukin 1beta (IL-1beta)], and alleviated neutrophil infiltration in ischemic spinal cord.	Glycyrrhizic Acid	46-58	interleukin 1 beta	Mus musculus	293-310
23594088-10	2013	RESULTS: Compared with the control group, the glycyrrhizin group showed significantly improved neurologic outcome, reduced apoptosis of motoneurons of spinal anterior horn, decreased the activation of NF-kappaB and subsequent inflammatory cytokines expression [tumor necrosis factor (TNF) and interleukin 1beta (IL-1beta)], and alleviated neutrophil infiltration in ischemic spinal cord.	Glycyrrhizic Acid	46-58	interleukin 1 beta	Mus musculus	312-320
23609920-11	2013	CONCLUSIONS: These results suggest that exendin-4 protects against IL-1beta- induced apoptosis in beta-cells via downregulation of the NF- kappaB-iNOS-nitrite pathway.	Nitrites	151-158	interleukin 1 beta	Mus musculus	67-75
24078693-2	2013	We found a heretofore unappreciated role for caspase-8 as a major pathway for IL-1beta processing and release in murine bone marrow-derived dendritic cells (BMDC) costimulated with TLR4 agonists and proapoptotic chemotherapeutic agents such as doxorubicin (Dox) or staurosporine (STS).	Doxorubicin	244-255	interleukin 1 beta	Mus musculus	78-86
24078693-4	2013	Notably, Dox-induced production of mature IL-1beta was temporally correlated with caspase-8 activation in WT cells and greatly suppressed in Casp8(-/-)Rip3(-/-) or Trif(-/-) BMDC, as well as in WT BMDC treated with the caspase-8 inhibitor, IETD.	bmdc	174-178	interleukin 1 beta	Mus musculus	42-50
24152426-9	2013	Cultured neurons derived from STZ-diabetic mice were treated for 24 hr with IL-1beta and maximal oxygen consumption rate and spare respiratory capacity, both key measures of bioenergetic fidelity that were depressed in diabetic compared with control neurons, were enhanced 2-fold.	Streptozocin	30-33	interleukin 1 beta	Mus musculus	76-84
24078693-4	2013	Notably, Dox-induced production of mature IL-1beta was temporally correlated with caspase-8 activation in WT cells and greatly suppressed in Casp8(-/-)Rip3(-/-) or Trif(-/-) BMDC, as well as in WT BMDC treated with the caspase-8 inhibitor, IETD.	IETD	240-244	interleukin 1 beta	Mus musculus	42-50
24078693-5	2013	Similarly, STS stimulated robust IL-1beta processing and release in Casp1(-/-)Casp11(-/-) BMDC that was IETD sensitive.	IETD	104-108	interleukin 1 beta	Mus musculus	33-41
24078693-6	2013	These data suggest that TLR4 induces assembly of caspase-8-based signaling complexes that become licensed as IL-1beta-converting enzymes in response to Dox and STS.	Doxorubicin	152-155	interleukin 1 beta	Mus musculus	109-117
24400155-8	2013	CLP induction of renal inflammatory gene (IL-6, TNF-alpha, IL-1beta) expression was attenuated by NAH pretreatment.	Niacin	98-101	interleukin 1 beta	Mus musculus	59-67
24089003-9	2013	Hydrocortisone therapy of TLR2 mice completely abolished this advantage (decrease in survival to 45%, P &lt; 0.05 vs. vehicle-treated TLR2 mice) and was associated with decreased IL-1beta plasma concentrations.	Hydrocortisone	0-14	interleukin 1 beta	Mus musculus	179-187
23669123-10	2013	RESULTS: Fluorescence staining and flow cytometry results showed that IL-1 beta markedly increased intracellular ROS level, which could be prevented by fullerol administration.	Reactive Oxygen Species	113-116	interleukin 1 beta	Mus musculus	70-79
23669123-10	2013	RESULTS: Fluorescence staining and flow cytometry results showed that IL-1 beta markedly increased intracellular ROS level, which could be prevented by fullerol administration.	fullerol	152-160	interleukin 1 beta	Mus musculus	70-79
23669123-12	2013	Cellular production of matrix metalloproteinase (MMP)-1, 3, and 13 and tumor necrosis factor alpha (TNF-alpha) induced by IL-1 beta was suppressed by fullerol treatment.	fullerol	150-158	interleukin 1 beta	Mus musculus	122-131
24170042-3	2013	CD200R-deficient bone marrow derived macrophages (BMMPhi) were used to demonstrate that macrophages lacking this inhibitory receptor exhibit enhanced levels of Vegfa, Arg-1 and Il-1beta when stimulated with PGE2 or RPE-conditioned (PGE2-enriched) media.	Dinoprostone	207-211	interleukin 1 beta	Mus musculus	177-185
23921145-1	2013	Emerging evidence has demonstrated that saturated fatty acids prime pro-IL-1beta production and inflammasome-mediated IL-1beta activation is critical in obesity-associated insulin resistance (IR).	Fatty Acids	40-61	interleukin 1 beta	Mus musculus	72-80
24147174-9	2013	Glyburide treatment did not affect glucose levels but was associated with reduced pulmonary cellular influx, reduced bacterial dissemination to both liver and spleen and reduced IL1beta production when compared to untreated controls.	Glyburide	0-9	interleukin 1 beta	Mus musculus	178-185
24147174-12	2013	Glyburide directly reduced the secretion of IL1beta by BMDMs in a dose-dependent fashion.	Glyburide	0-9	interleukin 1 beta	Mus musculus	44-51
24147174-14	2013	We further show, for the first time in any model of sepsis, that glyburide acts as an anti-inflammatory agent by reducing IL1beta secretion accompanied by diminished cellular influx and reduced bacterial dissemination to distant organs.	Glyburide	65-74	interleukin 1 beta	Mus musculus	122-129
24116148-6	2013	Compound 1h also reduced secretion of IL-6 and tumor necrosis factor-alpha by LPS-activated J774A.1 murine macrophage cells, primary mice peritoneal macrophages, and JAWSII murine bone marrow-derived dendritic cells and reduced NLRP3 inflammasome-mediated interleukin-1beta (IL-1beta) secretion by LPS + adenosine triphosphate-activated J774A.1 and JAWSII cells.	Hydrogen	9-11	interleukin 1 beta	Mus musculus	256-273
24116148-6	2013	Compound 1h also reduced secretion of IL-6 and tumor necrosis factor-alpha by LPS-activated J774A.1 murine macrophage cells, primary mice peritoneal macrophages, and JAWSII murine bone marrow-derived dendritic cells and reduced NLRP3 inflammasome-mediated interleukin-1beta (IL-1beta) secretion by LPS + adenosine triphosphate-activated J774A.1 and JAWSII cells.	Hydrogen	9-11	interleukin 1 beta	Mus musculus	275-283
24052904-6	2013	Moreover, increased caspase-1 dependent IL-1beta secretion with increased expression of NLRP3 inflammasome and phospho-NFkappaBp65 were observed in LGALS3(-/-) peritoneal macrophages stimulated in vitro by lipopolysaccharide and/or saturated fatty acid palmitate.	saturated fatty acid palmitate	232-262	interleukin 1 beta	Mus musculus	40-48
24022484-8	2013	Lactic acidosis, induced by the addition of 25 mm lactic acid, also induced the release of 20-kDa IL-1beta.	Lactic Acid	50-61	interleukin 1 beta	Mus musculus	98-106
24022484-10	2013	These data suggest that under disease relevant acidosis, DAMPs and lactic acid induce the secretion of IL-1beta independently of the inflammasome.	Lactic Acid	67-78	interleukin 1 beta	Mus musculus	103-111
23958343-9	2013	In addition, we found that edaravone suppressed interleukin (IL)-1beta-induced secretion of monocyte chemoattractant protein-1 (MCP-1), which was reported to increase cell permeability.	Edaravone	27-36	interleukin 1 beta	Mus musculus	48-70
23954279-15	2013	Meanwhile, the mRNA expressions of iNOS, IL-6, IL-1beta, MCP-1 in mice liver and kidney were significantly reduced by DHI.	dehydrosoyasaponin I	118-121	interleukin 1 beta	Mus musculus	47-55
23954279-19	2013	Furthermore, the mRNA expressions of iNOS, COX-2, TNF-alpha, IL-1beta, IL-6 and MCP-1 analyzed by real-time RT-PCR were suppressed by DHI.	dehydrosoyasaponin I	134-137	interleukin 1 beta	Mus musculus	61-69
23954279-20	2013	CONCLUSIONS: These results demonstrate that DHI exerts the protective effect through inhibiting the expressions of iNOS, COX-2, IL-1beta, IL-6, MCP-1 and TNF-alpha, which elucidate that DHI may be a strongly multi-target Chinese medicine injection on improving the inflammatory diseases.	dehydrosoyasaponin I	44-47	interleukin 1 beta	Mus musculus	128-136
23969119-7	2013	WT mice after PQ exposure displayed deteriorate cardiac function, pathological damages, increased TLR4 mRNA and protein levels as well as myocardial TNF-alpha and IL-1beta levels.	Paraquat	14-16	interleukin 1 beta	Mus musculus	163-171
23773309-0	2013	Interleukin-1beta (IL-1beta) increases pain behavior and the blood glucose level: possible involvement of glucocorticoid system.	Glucose	67-74	interleukin 1 beta	Mus musculus	0-17
23819539-0	2013	Synthesis of 1,4-anthracene-9,10-dione derivatives and their regulation of nitric oxide, IL-1beta and TNF-alpha in activated RAW264.7 cells.	1,4-anthracene-9,10-dione	13-38	interleukin 1 beta	Mus musculus	89-97
23819539-3	2013	The disubstituted 1,4-anthracene-9,10-dione 10 showed significant inhibition of nitric oxide, TNF-alpha and IL-1beta production at the concentration of 5 mug/mL, with a much lower cytotoxicity than mitoxantrone.	1,4-anthracene-9,10-dione	18-43	interleukin 1 beta	Mus musculus	108-116
23888334-3	2013	A2 also showed a stronger inhibitory effect than curcumin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in NF-kappaB activation and IL-1beta expression as well as in aldose reductase activity.	Curcumin	49-57	interleukin 1 beta	Mus musculus	150-158
23888334-3	2013	A2 also showed a stronger inhibitory effect than curcumin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in NF-kappaB activation and IL-1beta expression as well as in aldose reductase activity.	Tetradecanoylphorbol Acetate	61-97	interleukin 1 beta	Mus musculus	150-158
23888334-5	2013	In vivo studies indicated that A2 was more potent than curcumin for inhibiting TPA-induced ear edema and TPA-induced increases in IL-1beta.	Curcumin	55-63	interleukin 1 beta	Mus musculus	130-138
23888334-5	2013	In vivo studies indicated that A2 was more potent than curcumin for inhibiting TPA-induced ear edema and TPA-induced increases in IL-1beta.	Tetradecanoylphorbol Acetate	105-108	interleukin 1 beta	Mus musculus	130-138
23619613-5	2013	Processing of polysialylated NCAM was reproduced in a mouse model by bleomycin administration leading to an activation of the inflammasome and secretion of interleukin (IL)-1beta.	Bleomycin	69-78	interleukin 1 beta	Mus musculus	156-178
23764549-6	2013	The effects of IL-1beta on lymphatic pumping were abated by pre-treatment with an inhibitor of inducible nitric oxide synthase, L-NIL (N-iminoethyl-L-lysine).	L-NIL	128-133	interleukin 1 beta	Mus musculus	15-23
23764549-6	2013	The effects of IL-1beta on lymphatic pumping were abated by pre-treatment with an inhibitor of inducible nitric oxide synthase, L-NIL (N-iminoethyl-L-lysine).	n-iminoethyl-l-lysine	135-156	interleukin 1 beta	Mus musculus	15-23
23773309-0	2013	Interleukin-1beta (IL-1beta) increases pain behavior and the blood glucose level: possible involvement of glucocorticoid system.	Glucose	67-74	interleukin 1 beta	Mus musculus	19-27
23773309-10	2013	administration of IL-1beta significantly increased the plasma corticosterone level up to 60 min.	Corticosterone	62-76	interleukin 1 beta	Mus musculus	18-26
23773309-11	2013	In addition, the adrenalectomy caused the reductions of the blood glucose level and pain behavior induced by IL-1beta injected i.t.	Glucose	66-73	interleukin 1 beta	Mus musculus	109-117
23773309-14	2013	pretreatment with RU486 (100mg/kg) attenuated the blood glucose level and pain behavior induced by IL-1beta administered i.t.	Mifepristone	18-23	interleukin 1 beta	Mus musculus	99-107
23744365-10	2013	In addition, PDTC pretreatment reduced ethanol-stimulated expression of the inflammatory modulators, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), in serum.	Ethanol	39-46	interleukin 1 beta	Mus musculus	101-118
23744365-10	2013	In addition, PDTC pretreatment reduced ethanol-stimulated expression of the inflammatory modulators, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), in serum.	Ethanol	39-46	interleukin 1 beta	Mus musculus	120-128
23773309-14	2013	pretreatment with RU486 (100mg/kg) attenuated the blood glucose level and pain behavior induced by IL-1beta administered i.t.	Glucose	56-63	interleukin 1 beta	Mus musculus	99-107
24436715-9	2013	Results In the murine NP cells, NCCM inhibits IL-1beta + FasL- and Etoposide-mediated apoptosis via suppression of activated caspase-9 and caspase-3/7, CDCM demonstrated an inhibitory effect on IL-1beta + FasL-mediated apoptosis via <protein-id="12367;12369">caspase-3/7 (Fig.	cdcm	152-156	interleukin 1 beta	Mus musculus	194-202
23835343-5	2013	Irf4(-/-) macrophages produce higher levels of proinflammatory cytokines, including interleukin-1beta and tumor necrosis factor-alpha, in response to fatty acids.	Fatty Acids	150-161	interleukin 1 beta	Mus musculus	84-133
23835040-14	2013	IMI and DOXY prevented and reversed LPS-induced increase in IL-1beta.	Doxycycline	8-12	interleukin 1 beta	Mus musculus	60-68
23810410-10	2013	Thalidomide decreased production of inflammatory and fibrogenic cytokine tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and transforming growth factor (TGF)-beta1.	Thalidomide	0-11	interleukin 1 beta	Mus musculus	108-130
23831012-5	2013	An in vivo anti-inflammatory effect of CAPE treated diabetic mice was observed, based on a significant decrease in IL-1beta and IFN-gamma (P&lt;0.01) levels and a highly significant reduction in NO (P&lt;0.001).	caffeic acid phenethyl ester	39-43	interleukin 1 beta	Mus musculus	115-123
23912334-3	2013	SP reduces inflammatory responses measured as the decreased number of infiltrating inflammatory macrophages and neutrophils and decreased expression of proinflammatory cytokines interleukin 1beta (IL-1beta), IL-6, and IL-17A.	sepiapterin	0-2	interleukin 1 beta	Mus musculus	178-195
24133613-7	2013	Overall, PNO consumption resulted in a higher production of IL-1beta (P = 0.04).	pentanal	9-12	interleukin 1 beta	Mus musculus	60-68
23912334-3	2013	SP reduces inflammatory responses measured as the decreased number of infiltrating inflammatory macrophages and neutrophils and decreased expression of proinflammatory cytokines interleukin 1beta (IL-1beta), IL-6, and IL-17A.	sepiapterin	0-2	interleukin 1 beta	Mus musculus	197-205
23917218-6	2013	In addition, melatonin significantly decreased microglial activation and overproduction of pro-inflammatory mediators (tumor necrosis factor-alpha, interleukin-1beta and nitric oxide) from 3 to 30 days after hypoxia, possibly by inhibiting NF-kappaB activation in the hippocampus.	Melatonin	13-22	interleukin 1 beta	Mus musculus	148-165
23855752-11	2013	Naloxone (1 mg/kg) prevented the inhibitory effect of the extract over carrageenin-induced mechanical (100%) and thermal (100%) hyperalgesia, neutrophil recruitment (52%) and TNFalpha (63%) and IL-1beta (98%) production, thermal threshold in naive mice (99%), PGE2-induced mechanical hyperalgesia (88%) and acetic acid-induced writhing response (49%).	Naloxone	0-8	interleukin 1 beta	Mus musculus	194-202
23855752-11	2013	Naloxone (1 mg/kg) prevented the inhibitory effect of the extract over carrageenin-induced mechanical (100%) and thermal (100%) hyperalgesia, neutrophil recruitment (52%) and TNFalpha (63%) and IL-1beta (98%) production, thermal threshold in naive mice (99%), PGE2-induced mechanical hyperalgesia (88%) and acetic acid-induced writhing response (49%).	Carrageenan	71-82	interleukin 1 beta	Mus musculus	194-202
23208998-8	2013	Pre-treatment with lupeol (50 and 100 mg/kg) inhibited the hyperalgesia and the local increase in tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) levels induced by carrageenan.	lupeol	19-25	interleukin 1 beta	Mus musculus	142-159
23208998-8	2013	Pre-treatment with lupeol (50 and 100 mg/kg) inhibited the hyperalgesia and the local increase in tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) levels induced by carrageenan.	lupeol	19-25	interleukin 1 beta	Mus musculus	161-169
23208998-8	2013	Pre-treatment with lupeol (50 and 100 mg/kg) inhibited the hyperalgesia and the local increase in tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) levels induced by carrageenan.	Carrageenan	189-200	interleukin 1 beta	Mus musculus	142-159
23208998-8	2013	Pre-treatment with lupeol (50 and 100 mg/kg) inhibited the hyperalgesia and the local increase in tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) levels induced by carrageenan.	Carrageenan	189-200	interleukin 1 beta	Mus musculus	161-169
24047432-0	2013	Iron oxide nanoparticles suppress the production of IL-1beta via the secretory lysosomal pathway in murine microglial cells.	ferric oxide	0-10	interleukin 1 beta	Mus musculus	52-60
23980097-3	2013	In this study, we show that, after conditioning therapy, intestinal commensal bacteria and the damage-associated molecular pattern uric acid contribute to Nlrp3 inflammasome-mediated IL-1beta production and that gastrointestinal decontamination and uric acid depletion reduced GvHD severity.	Uric Acid	131-140	interleukin 1 beta	Mus musculus	183-191
23970467-7	2013	Relative to vehicle, L-carnitine treatment of mouse dry eye for 14 days (days 21 to 35) resulted in a significant reduction in corneal staining, number of TUNEL-positive cells, and expression of TNF-alpha, IL-17, IL-6, or IL-1beta, as well as significantly increased the number of goblet cells.	Carnitine	21-32	interleukin 1 beta	Mus musculus	222-230
24048854-9	2013	Furthermore, the well tolerated COX inhibitor ibuprofen was protective against IL-1beta-induced deficits.	Ibuprofen	46-55	interleukin 1 beta	Mus musculus	79-87
23900151-11	2013	In sharp contrast, DHMEQ treatment markedly improved the normoglycemic rate, which was associated with the suppression of serum high mobility group complex-1 (HMGB1) and proinflammatory cytokines, including tumor necrosis factor-alpha, monocyte chemoattractant protein-1, macrophage inflammatory protein-1beta, interleukin-1beta, and interleukin-6, after PITx.	dehydroxymethylepoxyquinomicin	19-24	interleukin 1 beta	Mus musculus	311-328
24048854-10	2013	These data demonstrate that progressive microglial COX-1 expression and prostaglandin synthesis can underpin susceptibility to cognitive deficits, which can be triggered by systemic LPS-induced IL-1beta.	Prostaglandins	72-85	interleukin 1 beta	Mus musculus	194-202
23685326-6	2013	OKA administration resulted in memory impairment with a decreased cerebral blood flow (CBF) (measured by laser doppler flowmetry), ATP level and increased mitochondrial (Ca(2+))i, neuroinflammation (increased TNF-alpha, IL-1beta, COX-2 and GFAP), oxidative-nitrosative stress, increased Caspase-9 and cholinergic dysfunction (decreased AChE activity/expression and alpha7 nicotinic acetylcholine receptor expression) in cerebral cortex and hippocampus of mice brain.	Okadaic Acid	0-3	interleukin 1 beta	Mus musculus	220-228
23566359-9	2013	Pro-inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) were also reduced significantly in a dose dependent manner in all the TPA treated groups as compared to control.	Tetradecanoylphorbol Acetate	128-131	interleukin 1 beta	Mus musculus	28-36
23500890-4	2013	Using the brains of TLR4(+/+) and TLR4(-/-) (TLR4-KO) mice, we report that chronic ethanol treatment induces inflammatory mediators (iNOS and COX-2), cytokines (IL-1beta, TNF-alpha), gliosis processes, caspase-3 activation and neuronal loss in the cerebral cortex of both female and male mice.	Ethanol	83-90	interleukin 1 beta	Mus musculus	161-169
23707980-8	2013	Chronic morphine also increases IL-1beta expression in GFAP-expressing astrocytes, which is abolished in tPA-deficient mice.	Morphine	8-16	interleukin 1 beta	Mus musculus	32-40
23707980-9	2013	In cultured astrocytes, morphine treatment increases tPA, IL-1beta, and pERK expression, and the increased IL-1beta and pERK expression is abolished in tPA-deficient astrocytes.	Morphine	24-32	interleukin 1 beta	Mus musculus	58-66
23880231-7	2013	Here we found that stearic acid, a prototypic saturated fatty acid, stimulated Akt-dependent activation of NF-kappaB resulting in increased levels of proinflammatory mediators [TNF-alpha, interleukin (IL)-1beta, COX-2] in macrophages leading, in turn, to the induction of aromatase.	stearic acid	19-31	interleukin 1 beta	Mus musculus	188-210
23871805-6	2013	Conversely, our results revealed that bioactive RS-GRA treatment significantly counteracts the changes in all these parameters and preserves TJ integrity reducing the production of pro-inflammatory cytokines, such as TNF-alpha and IL-1beta, and increasing the production of IL-10, an anti-inflammatory cytokine.	rs-gra	48-54	interleukin 1 beta	Mus musculus	231-239
23836031-3	2013	Overnight exposure to IL-1B+IL-6 in islets isolated from normal mice and humans disrupted glucose-stimulated intracellular calcium responses; cytokine-induced effects were more severe among islets from prediabetic db/db mice that otherwise showed no signs of dysfunction.	Glucose	90-97	interleukin 1 beta	Mus musculus	22-27
23836031-3	2013	Overnight exposure to IL-1B+IL-6 in islets isolated from normal mice and humans disrupted glucose-stimulated intracellular calcium responses; cytokine-induced effects were more severe among islets from prediabetic db/db mice that otherwise showed no signs of dysfunction.	Calcium	123-130	interleukin 1 beta	Mus musculus	22-27
23836031-4	2013	IL-1B+IL-6 exposure reduced endoplasmic reticulum (ER) calcium storage, activated ER stress responses (Nos2, Bip, Atf4, and Ddit3 [CHOP]), impaired glucose-stimulated insulin secretion, and increased cell death only in islets from prediabetic db/db mice.	Calcium	55-62	interleukin 1 beta	Mus musculus	0-5
23836031-4	2013	IL-1B+IL-6 exposure reduced endoplasmic reticulum (ER) calcium storage, activated ER stress responses (Nos2, Bip, Atf4, and Ddit3 [CHOP]), impaired glucose-stimulated insulin secretion, and increased cell death only in islets from prediabetic db/db mice.	Glucose	148-155	interleukin 1 beta	Mus musculus	0-5
23570902-8	2013	Moreover, rolipram reduced the invasion of neutrophils as well as the expression of the proinflammatory cytokines IL-1beta and TNFalpha but increased the levels of TGFbeta-1.	Rolipram	10-18	interleukin 1 beta	Mus musculus	114-122
23742179-8	2013	Treatment with TNBS caused colon shortening; increased myeloperoxidase activity; and increased IL-1beta, IL-6 and TNF-alpha expression in mice.	Trinitrobenzenesulfonic Acid	15-19	interleukin 1 beta	Mus musculus	95-103
23669335-6	2013	In vitro, we also observed that alpinetin inhibited the expression of TLR4 and the production of TNF-alpha, IL-1beta and IL-6 in LPS-stimulated primary mouse mammary epithelial cells.	alpinetin	32-41	interleukin 1 beta	Mus musculus	108-116
23906708-3	2013	Surfactin significantly suppressed expression of MMP-9, iNOS and COX-2, as well as production of ROS, NO, PGE2, TNF-alpha, IL-1beta, IL-6 and MCP-1 in Abeta-stimulated BV-2 microglial cells.	surfactin peptide	0-9	interleukin 1 beta	Mus musculus	123-131
23561100-9	2013	Abrupt increases in proinflammatory cytokines such as IkappaB-alpha, TNF-alpha, IL-1beta and IL-6 in hepatocytes due to a chronic alcohol uptake were significantly suppressed by co-administration of EM-CFs.	Alcohols	130-137	interleukin 1 beta	Mus musculus	80-88
23796752-6	2013	Furthermore, we found that morphine enhanced the release of IL-1beta, TNF-alpha, IL-6, and of NO via mu-opioid receptor-PKCe signaling pathway in activated microglial cells, mediating a proinflammatory phenotype in mouse microglial cells.	Morphine	27-35	interleukin 1 beta	Mus musculus	60-68
23945080-13	2013	The levels of MMP-3, IL-1beta and RANKL were much lower in the DAAP-injected group than those of the control.	DAAP	63-67	interleukin 1 beta	Mus musculus	21-29
23770004-5	2013	In addition, procyanidin C1 functionally induced macrophage activation by augmenting the expression of cell surface molecules (CD80, CD86, and MHC II) and proinflammatory cytokine production (tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6) via activation of mitogen-activated protein kinase (MAPK), e.g., p38, ERK, and JNK and nuclear factor (NF)-kappaB signaling pathways.	Procyanidin C1	13-27	interleukin 1 beta	Mus musculus	227-249
23792039-8	2013	Furthermore, the complex form of 18beta-glycyrrhetinic acid and hydroxypropyl gammacyclodextrin reduced mRNA expressions of TNF-alpha, interleukin (IL)-1beta, and IL-6, which was histologically confirmed in the improvement of indomethacin-induced small intestinal damage.	18alpha-glycyrrhetinic acid	33-59	interleukin 1 beta	Mus musculus	135-157
23792039-8	2013	Furthermore, the complex form of 18beta-glycyrrhetinic acid and hydroxypropyl gammacyclodextrin reduced mRNA expressions of TNF-alpha, interleukin (IL)-1beta, and IL-6, which was histologically confirmed in the improvement of indomethacin-induced small intestinal damage.	hydroxypropyl gammacyclodextrin	64-95	interleukin 1 beta	Mus musculus	135-157
23792039-8	2013	Furthermore, the complex form of 18beta-glycyrrhetinic acid and hydroxypropyl gammacyclodextrin reduced mRNA expressions of TNF-alpha, interleukin (IL)-1beta, and IL-6, which was histologically confirmed in the improvement of indomethacin-induced small intestinal damage.	Indomethacin	226-238	interleukin 1 beta	Mus musculus	135-157
23791694-13	2013	After priming of the RAW 264.7 macrophage cell line with different TLR ligands, DON exposure differentially modulated IL-1beta, IL-10, and TNF-alpha production.	deoxynivalenol	80-83	interleukin 1 beta	Mus musculus	118-126
23806010-7	2013	The bicyclic compound dihydroxyindolizidine (21) reduced the proinflammatory cytokine (IL-1beta and TNF-alpha) levels in the LPS-activated Raw 264.7 cells without showing any enzyme-inhibition activity.	dihydroxyindolizidine	22-43	interleukin 1 beta	Mus musculus	87-95
23951048-1	2013	INTRODUCTION: Alcohol-induced neuroinflammation is mediated by pro-inflammatory cytokines and chemokines including tumor necrosis factor-alpha (TNFalpha), monocyte chemotactic protein-1 (MCP1) and interleukin-1-beta (IL-1beta).	Alcohols	14-21	interleukin 1 beta	Mus musculus	197-215
23951048-1	2013	INTRODUCTION: Alcohol-induced neuroinflammation is mediated by pro-inflammatory cytokines and chemokines including tumor necrosis factor-alpha (TNFalpha), monocyte chemotactic protein-1 (MCP1) and interleukin-1-beta (IL-1beta).	Alcohols	14-21	interleukin 1 beta	Mus musculus	217-225
23951048-10	2013	Deficiency in miR-155 protected mice from alcohol-induced increase in inflammatory cytokines; TNFalpha, MCP1 protein and TNFalpha, MCP1, pro-IL-1beta and pro-caspase-1 mRNA levels were reduced in miR-155 KO alcohol-fed mice.	Alcohols	42-49	interleukin 1 beta	Mus musculus	141-149
23915129-9	2013	MitoQ significantly ameliorated colitis in the dextran sulfate sodium-induced mouse model in vivo, reduced the increased oxidative stress response (malondialdehyde and 3-nitrotyrosine formation), and suppressed mitochondrial and histopathological injury by decreasing levels of inflammatory cytokines IL-1 beta and IL-18 (P &lt;0.001 and P &lt;0.01 respectively).	mitoquinone	0-5	interleukin 1 beta	Mus musculus	301-310
23915129-10	2013	By decreasing mitochondrial reactive oxygen species, MitoQ also suppressed activation of the NLRP3 inflammasome that was responsible for maturation of IL-1 beta and IL-18.	mitoquinone	53-58	interleukin 1 beta	Mus musculus	151-160
23967184-9	2013	However, niacin treatment attenuated HFD-induced increases in adipose tissue gene expression of MCP-1 and IL-1beta in the wild-type HFD-fed mice.	Niacin	9-15	interleukin 1 beta	Mus musculus	106-114
23692952-6	2013	In addition, 8-OH-DPAT reversed the increase in the inflammatory factor IL-1beta in the dentate gyrus and amygdala but did not reduce positive TUNEL staining in the dentate gyrus.	8-Hydroxy-2-(di-n-propylamino)tetralin	13-22	interleukin 1 beta	Mus musculus	72-80
23681119-9	2013	Increases in the mRNA levels of genes encoding cytokines derived from Kupffer cells, such as Il1b and Tnf, and cell cycle-related genes, such as Ccnd1 and Ccne1, suggested that FL treatment increases compensatory cell proliferation.	flumequine	177-179	interleukin 1 beta	Mus musculus	93-97
23770347-7	2013	Furthermore, immunoblotting analysis of placental tissue harvested from our murine models revealed DMA-mediated regulation of expression of the proinflammatory cytokines IL-1beta, tumor necrosis factor alpha, and IL-6, and increased expression of the regulatory inflammatory cytokine IL-10.	dimethylacetamide	99-102	interleukin 1 beta	Mus musculus	170-178
23766264-7	2013	In vitro, the inhibitors of PKCbeta and extracellular signal-regulated kinase 1/2, as well as small interfering RNA to Egr-1, significantly decreased high-glucose-induced expression of CD11c (integrin, alpha X 9 complement component 3 receptor 4 subunit]), chemokine (C-C motif) ligand 2, and interleukin-1beta in U937 macrophages.	Glucose	155-162	interleukin 1 beta	Mus musculus	293-310
23469860-7	2013	In addition, treatment with IL1ra plus L-NAME produced an additive inhibition of LPS-induced vascular hyporeactivity, suggesting different signalling pathways between IL-1beta and NOS (NO synthase).	NG-Nitroarginine Methyl Ester	39-45	interleukin 1 beta	Mus musculus	167-175
23727179-6	2013	Furthermore, flavokawain A suppressed LPS-induced expression of pro-inflammatory cytokines, such as TNF-alpha, IL-1beta and IL-6.	flavokawain A	13-26	interleukin 1 beta	Mus musculus	111-119
23499837-4	2013	Dietary GW0742 prevented the acute increase in IL-1beta mRNA and ERK phosphorylation measured at 3h after a single 10-Gy dose of WBI; it also prevented the increase in the number of activated hippocampal microglia 1 week after WBI.	GW0742	8-14	interleukin 1 beta	Mus musculus	47-55
23664095-5	2013	Comparing to the IL-1R1(-/-) mice, infected WT mice with functional IL-1beta signaling had higher gastritis scores, higher IL-1beta and iNOS mRNA expression, higher nitric oxide (NO) production and increased frequency of E-cadherin (E-cad) methylation at all the time points analyzed.	Nitric Oxide	165-177	interleukin 1 beta	Mus musculus	68-76
26155222-4	2013	Lipopolysaccarides (LPS) induced the expression of TNF-alpha, IL-1beta, and IL-6.	lipopolysaccarides	0-18	interleukin 1 beta	Mus musculus	62-70
24009539-5	2013	Metformin reduced the production of NO, PGE2 and pro-inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) through down-regulation of NF-kappaB translocation in macrophages in a dose-dependent manner.	Metformin	0-9	interleukin 1 beta	Mus musculus	77-85
23651796-5	2013	Furthermore, shikonin significantly reduced the concentrations of TNF-alpha, IL-6 and IL-1beta in bronchoalveolar lavage fluid induced by LPS.	shikonin	13-21	interleukin 1 beta	Mus musculus	86-94
23946691-1	2013	Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine mixture (CM: TNF-alpha, IFN-gamma, and IL-1beta).	monorden	19-28	interleukin 1 beta	Mus musculus	241-249
23823704-11	2013	The expression of inflammatory cytokines IL-6 and IL-1beta decreased in tumors in oroxylin A-treated mice.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	82-92	interleukin 1 beta	Mus musculus	50-58
23844578-5	2013	RESULTS: TBMS1 significantly inhibited the production of the pro-inflammatory cytokines, TNF-alpha, IL-6 and IL-1beta in vitro and in vivo.	tubeimoside I	9-14	interleukin 1 beta	Mus musculus	109-117
26155222-11	2013	Fenofibrate inhibited LPS-induced TNF-alpha, IL-1beta, and IL-6 production in the serum and liver.	Fenofibrate	0-11	interleukin 1 beta	Mus musculus	45-53
26155222-11	2013	Fenofibrate inhibited LPS-induced TNF-alpha, IL-1beta, and IL-6 production in the serum and liver.	lps	22-25	interleukin 1 beta	Mus musculus	45-53
26155222-4	2013	Lipopolysaccarides (LPS) induced the expression of TNF-alpha, IL-1beta, and IL-6.	lps	20-23	interleukin 1 beta	Mus musculus	62-70
26155222-15	2013	CONCLUSIONS: Therefore, fenofibrate decreases the expression and secretion of TNF-alpha, IL-1beta, and IL-6 via the NF-kappaB signaling pathway, thus serving as therapeutic targets to attenuate inflammation that is involved in hepatic pathological progression.	Fenofibrate	24-35	interleukin 1 beta	Mus musculus	89-97
23727291-4	2013	Treatment with losartan decreased neutrophil recruitment, hypernociception and the production of TNF-alpha, IL-1beta and chemokine (C-X-C motif) ligand 1 in mice subjected to AIA.	Losartan	15-23	interleukin 1 beta	Mus musculus	108-116
23307759-9	2013	In addition, ST was effective against the increase of tumor necrosis factor-alpha and interleukin-1 beta levels and the decrease of interleukin-10 levels in hippocampus and prefrontal cortex.	st	13-15	interleukin 1 beta	Mus musculus	86-104
24244809-3	2013	RT-PCR showed that silibinin inhibits iNOS, TNF-alpha, and IL1beta.	Silybin	19-28	interleukin 1 beta	Mus musculus	59-66
23466506-13	2013	The expression of inflammatory cytokines interleukin 1 beta, interleukin 6, cyclooxygenase-2, and prostaglandin E2, was also inhibited by fullerol in a dose-dependent manner.	fullerol	138-146	interleukin 1 beta	Mus musculus	41-59
23659960-4	2013	After 4 months of exposure, in the DU300 group, the innate immune function decreased, manifesting as decreased secretion of nitric oxide, interleukin (IL)-1beta, IL-18, and tumour necrosis factor (TNF)-alpha in the peritoneal macrophages, as well as reduced cytotoxicity of the splenic natural killer cells.	du300	35-40	interleukin 1 beta	Mus musculus	138-160
23562577-10	2013	24h before pMCAO exacerbated ischemia-induced tumor necrosis factor-alpha (TNF-alpha) and IL-1beta, nitro-oxidative stress, and the presence of neutrophils at 8h, and increased infarct volume at day 4.	pmcao	11-16	interleukin 1 beta	Mus musculus	90-98
23864696-0	2013	Interleukin-1beta alters glutamate transmission at purkinje cell synapses in a mouse model of multiple sclerosis.	Glutamic Acid	25-34	interleukin 1 beta	Mus musculus	0-17
23636457-2	2013	Nucleotide-binding domain and leucine-rich repeat PYD-containing protein 3 (NLRP3) senses the ROS, triggering inflammasome activation and interleukin-1beta (IL-1beta) production and secretion.	Reactive Oxygen Species	94-97	interleukin 1 beta	Mus musculus	138-155
23636457-2	2013	Nucleotide-binding domain and leucine-rich repeat PYD-containing protein 3 (NLRP3) senses the ROS, triggering inflammasome activation and interleukin-1beta (IL-1beta) production and secretion.	Reactive Oxygen Species	94-97	interleukin 1 beta	Mus musculus	157-165
23702424-10	2013	Cerulein increased serum levels of amylase and lipase, and pro-inflammatory cytokines TNF-alpha, IL-1beta, and IL-6 were also decreased by 1,8-cineole pretreatment, similar to thalidomide, a TNF-alpha inhibitor.	Eucalyptol	139-150	interleukin 1 beta	Mus musculus	97-105
23874391-0	2013	Low molecular weight heparin relieves experimental colitis in mice by downregulating IL-1beta and inhibiting syndecan-1 shedding in the intestinal mucosa.	Heparin	21-28	interleukin 1 beta	Mus musculus	85-93
23874391-12	2013	In addition, LMWH significantly decreased the expression of both IL-1beta and IL-10 mRNA on days 12 and 20 (P&lt;0.05 vs. DSS group).	Heparin, Low-Molecular-Weight	13-17	interleukin 1 beta	Mus musculus	65-73
23866260-10	2013	In addition, the IL-1beta and IL-6 levels were significantly decreased in the GJHT group.	gjht	78-82	interleukin 1 beta	Mus musculus	17-25
23657858-5	2013	Urinary prostaglandin E metabolite (PGEM) excretion was also significantly increased at day 14 of IL-1beta infusion (1.21 +- 0.26 vs. 0.29 +- 0.06 ng/day in vehicle-infused mice; P = 0.001).	Prostaglandins E	8-23	interleukin 1 beta	Mus musculus	98-106
23657858-5	2013	Urinary prostaglandin E metabolite (PGEM) excretion was also significantly increased at day 14 of IL-1beta infusion (1.21 +- 0.26 vs. 0.29 +- 0.06 ng/day in vehicle-infused mice; P = 0.001).	13,14-Dihydro-15-keto-PGE2	36-40	interleukin 1 beta	Mus musculus	98-106
23657858-6	2013	The selective COX-2 inhibitor celecoxib markedly attenuated urinary PGEM excretion and abolished the diuretic response to chronic IL-1beta infusion.	Celecoxib	30-39	interleukin 1 beta	Mus musculus	130-138
23657858-8	2013	Consistent with a primary effect on water transport, IL-1beta infusion markedly reduced inner medullary aquaporin-2 expression (P &lt; 0.05) and did not alter urinary Na+ or K+ excretion.	Water	36-41	interleukin 1 beta	Mus musculus	53-61
23603994-9	2013	External polyamines reduced the levels of inflammatory mediators such as NO, TNFalpha, and IL-1beta in lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages.	Polyamines	9-19	interleukin 1 beta	Mus musculus	91-99
23678853-7	2013	However, oral administration of theacrine (10, 20, 30 mg/kg for 7 consecutive days) was found to decrease plasma ALT and AST levels, reduce hepatic mRNA levels of inflammatory mediators (IL-1beta, TNF-alpha, IL-6, and IFN-gamma), and reverse the histologic damages in stressed mice.	1,3,7,9-tetramethyluric acid	32-41	interleukin 1 beta	Mus musculus	187-195
23580606-7	2013	In vitro studies in cells from adult mice showed that myocardial fibroblasts released IL-1beta and IL-18 when primed with lipopolysaccharide and subsequently exposed to the danger signal adenosine triphosphate, a molecule released after tissue damage during MI.	Adenosine Triphosphate	187-209	interleukin 1 beta	Mus musculus	86-94
23376234-9	2013	We observed that MnTBAP and ebselen blocked IL-1beta secretion caused by SAA only when added before stimulation, and DPI augmented IL-1beta secretion.	diphenyleneiodonium	117-120	interleukin 1 beta	Mus musculus	131-139
23376234-11	2013	We also found that mitochondria-targeted drugs increased IL-1beta secretion regardless of their impact on mitochondrial function and ROS levels, suggesting that mitochondrial ROS-dependent and -independent mechanisms play a role in the Nlrp3 inflammasome/IL-1beta secretion axis in SAA-stimulated cells.	Reactive Oxygen Species	175-178	interleukin 1 beta	Mus musculus	57-65
23376234-12	2013	Finally, we found that FCCP significantly sustained the association of the Nlrp3 inflammasome complex, which could explain the most robust effect among the drugs tested in enhancing IL-1beta secretion in SAA-treated cells.	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	23-27	interleukin 1 beta	Mus musculus	182-190
23376234-13	2013	Overall, our data suggest that the Nlrp3 inflammasome/IL-1beta secretion axis is a very highly regulated inflammatory pathway that is susceptible not only to changes in mitochondrial or intracellular ROS, but also to changes in overall mitochondrial function.	Reactive Oxygen Species	200-203	interleukin 1 beta	Mus musculus	54-62
23455376-5	2013	Blocking of the interleukin (IL)-1beta signaling pathway by treatment with a caspase-1 inhibitor, YVAD, reduced cecal tumorigenesis in AhR(-/-) mice.	YVAD	98-102	interleukin 1 beta	Mus musculus	16-38
23434766-6	2013	The in vivo verification of anti-inflammation in peripheral blood mononuclear cells by DMA treatment was confirmed by tumor necrosis factor-alpha and interleukin-1beta measurements.	dimerumic acid	87-90	interleukin 1 beta	Mus musculus	150-167
23597448-5	2013	I3C also suppressed IL-1beta secretion in nigericin treated in vivo model.	Nigericin	42-51	interleukin 1 beta	Mus musculus	20-28
23603994-10	2013	Spermine had a higher inhibitory effect on the production of cytokines such as IL-1beta and TNFalpha in LPS-stimulated murine macrophages compared to other polyamines.	Spermine	0-8	interleukin 1 beta	Mus musculus	79-87
23649041-9	2013	IL-1beta-treated mice also showed impaired contractile reserve with a right shift of the dose-response curve to isoproterenol (P &lt; 0.05) at 4 h and 15 days.	Isoproterenol	112-125	interleukin 1 beta	Mus musculus	0-8
23583630-8	2013	Inactivation of caspase-1 by thymoquinone resulted in inhibition of IL-1beta and IL-18.	thymoquinone	29-41	interleukin 1 beta	Mus musculus	68-76
23934130-2	2013	Here, we found that in mice, subchronic administration of the psychoactive component of cannabis, delta9-tetrahydrocannabinol (THC), activated cerebellar microglia and increased the expression of neuroinflammatory markers, including IL-1beta.	Dronabinol	98-125	interleukin 1 beta	Mus musculus	233-241
23934130-2	2013	Here, we found that in mice, subchronic administration of the psychoactive component of cannabis, delta9-tetrahydrocannabinol (THC), activated cerebellar microglia and increased the expression of neuroinflammatory markers, including IL-1beta.	Dronabinol	127-130	interleukin 1 beta	Mus musculus	233-241
23934130-6	2013	Furthermore, administration of the immunosuppressant minocycline or an inhibitor of IL-1beta receptor signaling prevented the deficits in cerebellar function in Cb1(-/-) and THC-withdrawn mice.	Dronabinol	174-177	interleukin 1 beta	Mus musculus	84-92
23454360-5	2013	Moreover, alpha,beta-amyrin decreases the colonic pro-inflammatory mediators tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and keratinocyte-derived chemokine (CXCL1/KC), while up-regulating the IL-4 levels.	beta-amyrin	16-27	interleukin 1 beta	Mus musculus	112-134
23660699-6	2013	LPS-treated N2a cells exhibited a significant increase in the expression levels of IL-1beta, IL-6, TNF-alpha, NF-kappaB and iNOS, while the administration of ketamine eliminated the LPS-induced production of IL-1beta, IL-6, TNF-alpha, NF-kappaB and iNOS.	Ketamine	158-166	interleukin 1 beta	Mus musculus	208-216
23625200-0	2013	Alcohol-induced IL-1beta in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation.	Alcohols	0-7	interleukin 1 beta	Mus musculus	16-24
23625200-1	2013	Alcohol-induced neuroinflammation is mediated by proinflammatory cytokines, including IL-1beta.	Alcohols	0-7	interleukin 1 beta	Mus musculus	86-94
23625200-3	2013	We hypothesized that alcohol-induced inflammasome activation contributes to increased IL-1beta in the brain.	Alcohols	21-28	interleukin 1 beta	Mus musculus	86-94
23625200-7	2013	Increased caspase-1 activity and IL-1beta protein in ethanol-fed mice indicated inflammasome activation.	Ethanol	53-60	interleukin 1 beta	Mus musculus	33-41
23625200-8	2013	TLR4 deficiency protected from TNF-alpha, MCP-1, and attenuated alcohol-induced IL-1beta increases.	Alcohols	64-71	interleukin 1 beta	Mus musculus	80-88
23625200-11	2013	NLRP3- or ASC-deficient mice were protected from caspase-1 activation and alcohol-induced IL-1beta increase in the brain.	Alcohols	74-81	interleukin 1 beta	Mus musculus	90-98
23625200-14	2013	In conclusion, alcohol up-regulates and activates the NLRP3/ASC inflammasome, leading to caspase-1 activation and IL-1beta increase in the cerebellum.	Alcohols	15-22	interleukin 1 beta	Mus musculus	114-122
23357788-7	2013	In adult mice ip-injected with LPS we found that furanodien-6-one had strong cerebral anti-inflammatory properties by inhibiting liver and brain TNFalpha as well as IL-1beta expression.	furanodien-6-one	49-65	interleukin 1 beta	Mus musculus	165-173
23825622-0	2013	Curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting IL-1beta and IL-6 production in mice.	Curcumin	0-8	interleukin 1 beta	Mus musculus	78-86
24053909-9	2013	A intensely pulmonary cytokines such as IL-1beta, TNF-alpha, MCP-1 were induced by crystalline silica exposure, and partly inhibited by anti-IL-1beta.	Silicon Dioxide	95-101	interleukin 1 beta	Mus musculus	141-149
24053909-11	2013	And the mRNA levels of TGF-beta, collagen I and fibronectin were significantly decreased in silica+IL-1beta mAb group when compared with those in silica group at days 7, 28 and 84 (P &lt; 0.01).	Silicon Dioxide	92-98	interleukin 1 beta	Mus musculus	99-107
24053909-13	2013	However, the IFN-gamma/IL-4 ratios in silica+anti-IL-1beta group were significantly higher than those in silica group at 7, 28 and 84 days (P &lt; 0.05 or P &lt; 0.01).	Silicon Dioxide	38-44	interleukin 1 beta	Mus musculus	50-58
24053909-14	2013	CONCLUSION: IL-1beta may promote the pulmonary fibrosis in mice exposed to silica.	Silicon Dioxide	75-81	interleukin 1 beta	Mus musculus	12-20
23825622-8	2013	We inferred that curcumin was capable of impacting the IL-23/IL-17A axis by inhibiting IL-1beta/IL-6 and then indirectly down-regulating IL-17A/IL-22 production.	Curcumin	17-25	interleukin 1 beta	Mus musculus	87-95
24053909-0	2013	[The role of interleukin-1beta on the pulmonary fibrosis in mice exposed to crystalline silica].	Silicon Dioxide	88-94	interleukin 1 beta	Mus musculus	13-30
24053909-1	2013	OBJECTIVE: This study was designed to evaluate the role of interleukin (IL)-1beta in the development of fibrosis in mice exposed to silica.	Silicon Dioxide	132-138	interleukin 1 beta	Mus musculus	59-81
24053909-8	2013	RESULTS: The collagen deposition induced by silica in the lung tissues was partly inhibited by anti-IL-1beta.	Silicon Dioxide	44-50	interleukin 1 beta	Mus musculus	100-108
24053909-9	2013	A intensely pulmonary cytokines such as IL-1beta, TNF-alpha, MCP-1 were induced by crystalline silica exposure, and partly inhibited by anti-IL-1beta.	Silicon Dioxide	95-101	interleukin 1 beta	Mus musculus	40-48
23500096-8	2013	Furthermore, DHA treatment reduced carrageenan-induced activation of microglia, phosphorylation of p38 mitogen-activated protein kinase (MAPK), and production of proinflammatory cytokines (tumor necrosisfactor-alpha - TNF-alpha and interleukin-1beta - IL-1beta) in the L4-5 spinal cord.	Docosahexaenoic Acids	13-16	interleukin 1 beta	Mus musculus	232-249
23500096-8	2013	Furthermore, DHA treatment reduced carrageenan-induced activation of microglia, phosphorylation of p38 mitogen-activated protein kinase (MAPK), and production of proinflammatory cytokines (tumor necrosisfactor-alpha - TNF-alpha and interleukin-1beta - IL-1beta) in the L4-5 spinal cord.	Docosahexaenoic Acids	13-16	interleukin 1 beta	Mus musculus	252-260
23500096-8	2013	Furthermore, DHA treatment reduced carrageenan-induced activation of microglia, phosphorylation of p38 mitogen-activated protein kinase (MAPK), and production of proinflammatory cytokines (tumor necrosisfactor-alpha - TNF-alpha and interleukin-1beta - IL-1beta) in the L4-5 spinal cord.	Carrageenan	35-46	interleukin 1 beta	Mus musculus	232-249
23500096-8	2013	Furthermore, DHA treatment reduced carrageenan-induced activation of microglia, phosphorylation of p38 mitogen-activated protein kinase (MAPK), and production of proinflammatory cytokines (tumor necrosisfactor-alpha - TNF-alpha and interleukin-1beta - IL-1beta) in the L4-5 spinal cord.	Carrageenan	35-46	interleukin 1 beta	Mus musculus	252-260
23500096-9	2013	In cultured microglial cells, DHA dose-dependently reduced lipopolysaccharide (LPS)-induced phosphorylation of p38, production of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines (CCL2, CCL3 and CXCL10).	Docosahexaenoic Acids	30-33	interleukin 1 beta	Mus musculus	168-176
23825622-0	2013	Curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting IL-1beta and IL-6 production in mice.	Imiquimod	18-27	interleukin 1 beta	Mus musculus	78-86
23825622-6	2013	Real-time PCR showed that mRNA levels of IL-17A, IL-17F, IL-22, IL-1beta, IL-6 and TNF-alpha cytokines were decreased significantly by curcumin in ear skin, an effect similar to that of clobetasol.	Curcumin	135-143	interleukin 1 beta	Mus musculus	64-72
23349493-6	2013	In vitro stimulation of LGALS3(-/-) peritoneal macrophages with lipopolysaccharide (LPS) and saturated fatty acid palmitate caused increased caspase-1-dependent IL-1beta production and increased phosphorylation of NF-kappaB p65 compared with WT cells.	saturated fatty acid palmitate	93-123	interleukin 1 beta	Mus musculus	161-169
23755157-10	2014	In addition, urantide prevented the increases of proinflammatory cytokines such as TNF-alpha, IL-1beta and IFN-gamma, and activation of NF-kappaB signaling pathway induced by LPS/GalN in mice.	urotensin II (4-11), Pen(5)-Trp(7)-Orn(8)-	13-21	interleukin 1 beta	Mus musculus	94-102
23805328-6	2013	DSS treatment increased colonic mRNA expression of IL-1beta and IL-17A as well as inflammasome expression in both genotypes, but the abundance of TNFalpha was selectively increased in DSS treated Mttp-IKO mice.	dss	0-3	interleukin 1 beta	Mus musculus	51-59
23787115-8	2013	The concentrations of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and myeloperoxidase in BAL fluid were significantly inhibited by imatinib or nilotinib in mice of ALI during neutropenia recovery.	Imatinib Mesylate	145-153	interleukin 1 beta	Mus musculus	51-73
23787115-8	2013	The concentrations of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and myeloperoxidase in BAL fluid were significantly inhibited by imatinib or nilotinib in mice of ALI during neutropenia recovery.	nilotinib	157-166	interleukin 1 beta	Mus musculus	51-73
23840469-12	2013	Interleukin-1beta or tumor necrosis factor-alpha stimulated mitochondrial superoxide flash activity by 2-fold in vitro and 5-fold in situ, without altering individual flash properties except for reduction in spatial size due to mitochondrial fragmentation.	Superoxides	74-84	interleukin 1 beta	Mus musculus	0-48
23528361-5	2013	MATERIALS AND METHODS: We investigated the inhibitory action of ethanolic extract of Atropa acuminata (AAEE) on production of NO, TNF-alpha and IL-1beta in lipopolysaccharide (LPS)-stimulated RAW264.7 cells and also assayed it for COX 1/2 and 5-LOX inhibitory activities.	aaee	103-107	interleukin 1 beta	Mus musculus	144-152
23349493-7	2013	Transfection of LGALS3(-/-) macrophages with NLRP3 small interfering RNA attenuated IL-1beta production in response to palmitate and LPS plus palmitate.	Palmitates	119-128	interleukin 1 beta	Mus musculus	84-92
23536230-10	2013	Diphenyliodonium (DPI), an NOX inhibitor, blocked LPS-induced activation of microglia and production of ROS, TNFalpha, IL-1beta, and MCP-1.	diphenyliodonium	0-16	interleukin 1 beta	Mus musculus	119-127
23371012-8	2013	RESULTS: After 7 days, DSS-induced loss of body weight, increase of colitis score, shortening of colon length, pathological changes and elevated levels of TNF-alpha, IL-1beta, MDA, and MPO in colon lesions, were significantly suppressed by oral lactulose administration and intraperitoneally injected H2-rich saline.	dss	23-26	interleukin 1 beta	Mus musculus	166-174
23307012-7	2013	Treatment with H2S decreased IL-1beta, MCP-1, and MIP-2, and increased IL-10 expression in lungs of mice exposed to hyperoxia.	Hydrogen Sulfide	15-18	interleukin 1 beta	Mus musculus	29-37
23536230-10	2013	Diphenyliodonium (DPI), an NOX inhibitor, blocked LPS-induced activation of microglia and production of ROS, TNFalpha, IL-1beta, and MCP-1.	diphenyliodonium	18-21	interleukin 1 beta	Mus musculus	119-127
23563392-5	2013	However, PGS significantly inhibited the excessive production of NO, PGE2 and pro-inflammatory cytokines, including interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner without causing any cytotoxic effects.	Phosphatidylglycerols	9-12	interleukin 1 beta	Mus musculus	116-133
23207717-7	2013	In in vivo trail, p-cymene markedly suppressed the production of TNF-alpha and IL-1beta and increased IL-10 secretion.	4-cymene	18-26	interleukin 1 beta	Mus musculus	79-87
23623942-12	2013	Moreover, while IFN-gamma and IL-10 were not affected, torilin suppressed CIA-induced serum TNF-alpha, IL-1beta and IL-6 levels.	torilin	55-62	interleukin 1 beta	Mus musculus	103-111
23563392-5	2013	However, PGS significantly inhibited the excessive production of NO, PGE2 and pro-inflammatory cytokines, including interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner without causing any cytotoxic effects.	Phosphatidylglycerols	9-12	interleukin 1 beta	Mus musculus	135-143
23563488-4	2013	We found that GLGZD inhibited the inflammatory response in microglial cells as it significantly reduced LPS-induced expression of pro-inflammatory nitric oxide, tumour necrosis factor-alpha, interleukin (IL)-6 and IL-1beta in BV-2 cells, in a dose-dependent manner.	glgzd	14-19	interleukin 1 beta	Mus musculus	214-222
23550835-2	2013	In this article, we demonstrate that incubation of mouse primary cortical neurons (mPCNs) with IL-1beta increases the expression of the P2Y2 nucleotide receptor (P2Y2R) and that activation of the up-regulated receptor with UTP, a relatively selective agonist of the P2Y2R, increases neurite outgrowth.	Uridine Triphosphate	223-226	interleukin 1 beta	Mus musculus	95-103
23918873-7	2013	Additionally, 4% Lovaza  significantly decreased anti-dsDNA antibodies, reduced glomerulonephritis and attenuated lipopolysaccharide-induced pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) in splenocytes compared to placebo.	Omacor	17-23	interleukin 1 beta	Mus musculus	169-177
23918873-8	2013	4% Lovaza  was also shown to reduce the expression of inflammatory cytokines, including IL-1beta, IL-6 and TNF-alpha, while increasing renal anti-oxidant enzymes in comparison to placebo.	Omacor	3-9	interleukin 1 beta	Mus musculus	88-96
23417833-11	2013	Furthermore, paeoniflorin decreased the quantity of CD68+ cells, protein levels of TNF-alpha and IL-1beta, and phosphorylation of IkappaBalpha and NFkappaB-p65 in the heart after AB.	peoniflorin	13-25	interleukin 1 beta	Mus musculus	97-105
23550835-3	2013	Consistent with the accepted role of cofilin in the regulation of neurite extension, results indicate that incubation of IL-1beta-treated mPCNs with UTP increases the phosphorylation of cofilin, a response absent in PCNs isolated from P2Y2R(-/-) mice.	mpcns	138-143	interleukin 1 beta	Mus musculus	121-129
23550835-3	2013	Consistent with the accepted role of cofilin in the regulation of neurite extension, results indicate that incubation of IL-1beta-treated mPCNs with UTP increases the phosphorylation of cofilin, a response absent in PCNs isolated from P2Y2R(-/-) mice.	Uridine Triphosphate	149-152	interleukin 1 beta	Mus musculus	121-129
23550835-4	2013	Other findings indicate that function-blocking anti-alphav beta3/5 integrin antibodies prevent UTP-induced cofilin activation in IL-1beta-treated mPCNs, suggesting that established P2Y2R/alphav beta3/5 interactions that promote G12 -dependent Rho activation lead to cofilin phosphorylation involved in neurite extension.	Uridine Triphosphate	95-98	interleukin 1 beta	Mus musculus	129-137
23550835-4	2013	Other findings indicate that function-blocking anti-alphav beta3/5 integrin antibodies prevent UTP-induced cofilin activation in IL-1beta-treated mPCNs, suggesting that established P2Y2R/alphav beta3/5 interactions that promote G12 -dependent Rho activation lead to cofilin phosphorylation involved in neurite extension.	mpcns	146-151	interleukin 1 beta	Mus musculus	129-137
23550835-5	2013	Cofilin phosphorylation induced by UTP in IL-1beta-treated mPCNs is also decreased by inhibitors of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), suggesting a role for P2Y2R-mediated and Gq-dependent calcium mobilization in neurite outgrowth.	Uridine Triphosphate	35-38	interleukin 1 beta	Mus musculus	42-50
23550835-5	2013	Cofilin phosphorylation induced by UTP in IL-1beta-treated mPCNs is also decreased by inhibitors of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), suggesting a role for P2Y2R-mediated and Gq-dependent calcium mobilization in neurite outgrowth.	Calcium	210-217	interleukin 1 beta	Mus musculus	42-50
23506741-6	2013	Moreover, protein and mRNA levels of DSS-induced proinflammatory cytokines in colon, including TNF-alpha, IL-1beta, IL-18, IL-17A and IFN-gamma, were markedly suppressed by Fc11a-2.	Dextran Sulfate	37-40	interleukin 1 beta	Mus musculus	106-114
23769029-7	2013	Compared with nontreated animals, everolimus-treated animals showed significantly increased TNF-alpha (2741.6 +- 201.72 pg/mg; 1925 +- 185.81 pg/mg, P &lt; .05) and IL-1beta (11.47 +- 1.2 pg/mg; 4.3 +- 0.13 pg/mg, P &lt; .01) production on day 2 after IRI induction accompanied by significantly greater NF-kappaB/DNA binding activity and p65 nuclear expression (P &lt; .01).	Everolimus	34-44	interleukin 1 beta	Mus musculus	165-173
23769029-8	2013	Two hours after IRI induction, everolimus-treated animals showed significantly increased IL-1beta mRNA expression (P &lt; .05) followed by increased IL-1beta protein concentrations when compared with nontreated animals measured 6 hours after IRI induction (11.71 +- 1.5 pg/mg; 7.5 +- 1.11 pg/mg, P &lt; .01).	Everolimus	31-41	interleukin 1 beta	Mus musculus	89-97
23769029-8	2013	Two hours after IRI induction, everolimus-treated animals showed significantly increased IL-1beta mRNA expression (P &lt; .05) followed by increased IL-1beta protein concentrations when compared with nontreated animals measured 6 hours after IRI induction (11.71 +- 1.5 pg/mg; 7.5 +- 1.11 pg/mg, P &lt; .01).	Everolimus	31-41	interleukin 1 beta	Mus musculus	149-157
23769029-11	2013	These data suggested that everolimus potentiated innate immunity in the early phase of IRI, stimulating the production of NF-kappaB-driven proinflammatory cytokines such as TNF-alpha and IL-1beta.	Everolimus	26-36	interleukin 1 beta	Mus musculus	187-195
23717478-5	2013	ATP induced the secretion of IL-1beta and chemokines by murine bone marrow-derived macrophages in vitro.	Adenosine Triphosphate	0-3	interleukin 1 beta	Mus musculus	29-37
23717478-6	2013	Furthermore, the intraperitoneal injection of ATP elevated the levels of IL-1beta and chemokines in the mouse peritoneal lavage.	Adenosine Triphosphate	46-49	interleukin 1 beta	Mus musculus	73-81
23499795-6	2013	Moreover, TL2 also decreased Abeta-induced production of TNF-alpha, IL-1beta and IL-6 in BV2 microglia.	UNII-042A8N37WH	29-34	interleukin 1 beta	Mus musculus	68-76
23589298-7	2013	Our findings suggest an alternative role for caspase 1 activation in promoting adaptive responses to oxidative stress and, more specifically, in limiting reactive oxygen species production and damage in cells and tissues where IL1beta/IL18 are not highly expressed.	Reactive Oxygen Species	154-177	interleukin 1 beta	Mus musculus	227-234
23702880-7	2013	Inhibition of NF-kappaB signaling by BAY 11-7082 attenuated repressive effects of IL-1beta.	3-(4-methylphenylsulfonyl)-2-propenenitrile	37-48	interleukin 1 beta	Mus musculus	82-90
23671638-7	2013	Except for interleukin-1beta levels, other changes in the levels of biomarker could be inhibited by HC-030031 and capsazepine.	capsazepine	114-125	interleukin 1 beta	Mus musculus	11-28
23375938-10	2013	Arctigenin inhibited TNBS-induced IL-1beta, TNF-alpha and IL-6 expression, as well as PI3K, AKT and IKKbeta phosphorylation and NF-kappaB activation in mice, but increased IL-10 and CD204 expression.	Trinitrobenzenesulfonic Acid	21-25	interleukin 1 beta	Mus musculus	34-42
23415610-7	2013	CBG reduced colon weight/colon length ratio, myeloperoxidase activity, and iNOS expression, increased SOD activity and normalized interleukin-1beta, interleukin-10 and interferon-gamma changes associated to DNBS administration.	cannabigerol	0-3	interleukin 1 beta	Mus musculus	130-147
23371061-10	2013	These data implicate a role for caspase-1 and IL-1beta in the IL-1 receptor-dependent Th17 response manifest in NO2-promoted allergic airway disease.	Nitrogen Dioxide	112-115	interleukin 1 beta	Mus musculus	46-54
23088210-4	2013	This NADPH oxidase inhibition also resulted in diminished Hcys-induced inflammasome activation, evidenced by reduced caspase-1 activity and interleukin-1beta production.	Homocysteine	58-62	interleukin 1 beta	Mus musculus	140-157
23376588-3	2013	In the present study, we aimed to investigate whether the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) released by microglia, could affect cellular iron transportation in primary cultured ventral mesencephalic (VM) neurons.	Iron	203-207	interleukin 1 beta	Mus musculus	85-102
23376588-3	2013	In the present study, we aimed to investigate whether the pro-inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) released by microglia, could affect cellular iron transportation in primary cultured ventral mesencephalic (VM) neurons.	Iron	203-207	interleukin 1 beta	Mus musculus	104-112
23499865-7	2013	The productions of pro-inflammatory cytokines (IL-1beta, IL-2, IL-12 and TNFalpha) and JNK activity were remarkably reduced in the CsA-treated obese animals.	Cyclosporine	131-134	interleukin 1 beta	Mus musculus	47-55
23347081-8	2013	IL-33-induced hyperalgesia in naive mice was reduced by treatments targeting TNF, CXCL1, IL-1, endothelin receptors and COX while carrageenin-induced ST2-dependent TNF-alpha, CXCL1, IL-1beta, IL-10 and PGE2 production and preproET-1 mRNA expression.	Carrageenan	130-141	interleukin 1 beta	Mus musculus	182-190
23376588-4	2013	The results showed that IL-1beta or TNF-alpha treatment led to increased ferrous iron influx and decreased iron efflux in these cells, due to the upregulation of divalent metal transporter 1 with the iron response element (DMT1+IRE) and downregulation of ferroportin1 (FPN1).	Iron	107-111	interleukin 1 beta	Mus musculus	24-32
23376588-7	2013	Further experiments demonstrated that IL-1beta and TNF-alpha release was remarkably enhanced by iron load in activated microglia triggered by lipopolysaccharide or 1-methyl-4-phenylpyridinium (MPP(+)).	Iron	96-100	interleukin 1 beta	Mus musculus	38-46
23376588-7	2013	Further experiments demonstrated that IL-1beta and TNF-alpha release was remarkably enhanced by iron load in activated microglia triggered by lipopolysaccharide or 1-methyl-4-phenylpyridinium (MPP(+)).	1-Methyl-4-phenylpyridinium	164-191	interleukin 1 beta	Mus musculus	38-46
23376588-7	2013	Further experiments demonstrated that IL-1beta and TNF-alpha release was remarkably enhanced by iron load in activated microglia triggered by lipopolysaccharide or 1-methyl-4-phenylpyridinium (MPP(+)).	mangion-purified polysaccharide (Candida albicans)	193-196	interleukin 1 beta	Mus musculus	38-46
23376588-9	2013	These results suggested that IL-1beta and TNF-alpha released by microglia, especially under the condition of iron load, might contribute to iron accumulation in VM neurons by upregulating IRP1 and hepcidin levels through reactive oxygen/nitrogen species production.	Iron	109-113	interleukin 1 beta	Mus musculus	29-37
23376588-9	2013	These results suggested that IL-1beta and TNF-alpha released by microglia, especially under the condition of iron load, might contribute to iron accumulation in VM neurons by upregulating IRP1 and hepcidin levels through reactive oxygen/nitrogen species production.	Iron	140-144	interleukin 1 beta	Mus musculus	29-37
23376588-9	2013	These results suggested that IL-1beta and TNF-alpha released by microglia, especially under the condition of iron load, might contribute to iron accumulation in VM neurons by upregulating IRP1 and hepcidin levels through reactive oxygen/nitrogen species production.	reactive oxygen/nitrogen species	221-253	interleukin 1 beta	Mus musculus	29-37
23376588-4	2013	The results showed that IL-1beta or TNF-alpha treatment led to increased ferrous iron influx and decreased iron efflux in these cells, due to the upregulation of divalent metal transporter 1 with the iron response element (DMT1+IRE) and downregulation of ferroportin1 (FPN1).	Iron	81-85	interleukin 1 beta	Mus musculus	24-32
23376588-4	2013	The results showed that IL-1beta or TNF-alpha treatment led to increased ferrous iron influx and decreased iron efflux in these cells, due to the upregulation of divalent metal transporter 1 with the iron response element (DMT1+IRE) and downregulation of ferroportin1 (FPN1).	Iron	107-111	interleukin 1 beta	Mus musculus	24-32
23567782-9	2013	RESULTS: DSS-treated RNase-L-/- mice exhibited a significantly higher clinical score, delayed leukocyte infiltration, reduced expression of IFN-beta, tumor necrosis factor alpha, interleukin-1beta, and interleukin-18 at early times post-DSS exposure, and increased mortality as compared with wild-type mice.	Dextran Sulfate	9-12	interleukin 1 beta	Mus musculus	179-196
23435932-7	2013	RESULTS: Gossypol markedly attenuated the LPS-induced histological alterations in the lung and inhibited the production of TNF-alpha, IL-1beta and IL-6.	Gossypol	9-17	interleukin 1 beta	Mus musculus	134-142
23416143-7	2013	Chronic consumption of alcohol also stimulated abrupt increases in pro-inflammatory cytokines such as nuclear factor (NF)-kappaB, tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta in liver otherwise co-administration of CNF effectively suppressed production of these cytokines dose-dependently.	Alcohols	23-30	interleukin 1 beta	Mus musculus	168-190
23404341-5	2013	Neuroprotection was accompanied by decreased inflammation; 3,6"-DT-treated mice exhibited reduced expression of TNF, interleukin-1beta, and inducible nitric oxide synthase; reduced numbers of activated microglia/macrophages, astrocytes, and neutrophils; and reduced expression of intercellular adhesion molecule-1 in the ischemic brain tissue.	3,6'-dithiothalidomide	59-66	interleukin 1 beta	Mus musculus	117-134
23566812-3	2013	Furthermore, TMC suppressed tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production, and the phosphorylation and degradation of IkappaB-alpha as well as the LPS-stimulated nuclear translocation of p65 in macrophages.	4,2',5'-trihydroxy-4'-methoxychalcone	13-16	interleukin 1 beta	Mus musculus	72-89
23566812-3	2013	Furthermore, TMC suppressed tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production, and the phosphorylation and degradation of IkappaB-alpha as well as the LPS-stimulated nuclear translocation of p65 in macrophages.	4,2',5'-trihydroxy-4'-methoxychalcone	13-16	interleukin 1 beta	Mus musculus	91-99
23566812-5	2013	The effects of TMC on LPS-induced NO, PGE2, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1beta production were partially reversed by the HO inhibitor tin protoporphyrin (SnPP).	4,2',5'-trihydroxy-4'-methoxychalcone	15-18	interleukin 1 beta	Mus musculus	83-105
23566812-5	2013	The effects of TMC on LPS-induced NO, PGE2, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1beta production were partially reversed by the HO inhibitor tin protoporphyrin (SnPP).	tin protoporphyrin IX	161-179	interleukin 1 beta	Mus musculus	83-105
23566812-5	2013	The effects of TMC on LPS-induced NO, PGE2, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1beta production were partially reversed by the HO inhibitor tin protoporphyrin (SnPP).	S-Nitroso-N-propionyl-D,L-penicillamine	181-185	interleukin 1 beta	Mus musculus	83-105
23077110-9	2013	Polypropylene mesh implant induced a pro-inflammatory environment mediated by intense MMP-2 and -9 activities, NO release, and interleukin-1beta production peaking in 7 days and gradually decreasing after 15 days.	Polypropylenes	0-13	interleukin 1 beta	Mus musculus	127-144
23422335-16	2013	Meanwhile, the inflammatory mediators (e.g., TNF-alpha, IL-1beta and NO) were inhibited by TFA treatment both at the serum and mRNA levels.	Trifluoroacetic Acid	91-94	interleukin 1 beta	Mus musculus	56-64
23229926-8	2013	The infiltration of inflammatory cells (T cells and macrophages), and the production of proinflammatory cytokines (RANTES, tumor necrosis factor-alpha, interleukin-1beta and interferon-gamma) were reduced in paricalcitol-treated mice with IRI.	paricalcitol	208-220	interleukin 1 beta	Mus musculus	152-169
23576175-1	2013	A series of studies have recently demonstrated that the release of interleukin 1beta induced by monosodium urate crystals is central to the experimental gouty arthritis.	Uric Acid	96-112	interleukin 1 beta	Mus musculus	67-84
23898520-11	2013	RESULTS: (1) The DAI scores, the levels of TNF-alpha and IL-1beta in SB203580 group were lower significantly compared with DSS group (P &lt; 0.05), and were increased significantly compared with normal control group (P &lt; 0.05).	SB 203580	69-77	interleukin 1 beta	Mus musculus	57-65
23898520-12	2013	(2) The levels of TNF-alpha and IL-1beta in intestinal mucosal biopsy specimens in SB203580 treatment group were lower significantly than those in UC group (P &lt; 0.05).	SB 203580	83-91	interleukin 1 beta	Mus musculus	32-40
23898520-13	2013	CONCLUSION: SB203580 can inhibit p38MAPK signal transduction pathway, then reduce the expression of pro-inflammatory cytokine TNF-alpha and IL-1beta.	SB 203580	12-20	interleukin 1 beta	Mus musculus	140-148
23206318-6	2013	Ethanol treatment of brain slice culture released HMGB1 into the media and induced the proinflammatory cytokine, interleukin-1 beta (IL-1beta).	Ethanol	0-7	interleukin 1 beta	Mus musculus	113-131
23190263-13	2013	Treatment decreased the level of the CCI-induced proinflammatory cytokine interleukin (IL)-1beta and activated the anti-inflammatory cytokine IL-10 in the lesioned nerve.	CCI	37-40	interleukin 1 beta	Mus musculus	74-96
23535595-0	2013	Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha.	Succinic Acid	0-9	interleukin 1 beta	Mus musculus	49-57
23535595-2	2013	Here we show that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1beta but not tumour-necrosis factor-alpha in mouse macrophages.	Deoxyglucose	48-62	interleukin 1 beta	Mus musculus	101-118
23535595-8	2013	We therefore identify succinate as a metabolite in innate immune signalling, which enhances interleukin-1beta production during inflammation.	Succinic Acid	22-31	interleukin 1 beta	Mus musculus	92-109
23577872-2	2013	However, the precise source of IL-1beta producing cells in DSS colitis is currently not known.	dss	59-62	interleukin 1 beta	Mus musculus	31-39
21153483-2	2013	Here, we show the protective effects of TZDs on mouse pancreatic beta-cell line cells (NIT-1) impaired by exposure to inflammatory cytokines (IL-1beta and IFN-gamma) and explore the potential mechanisms for this.	Thiazolidinediones	40-44	interleukin 1 beta	Mus musculus	142-150
21153483-6	2013	Additionally, the enhancement of PPARgamma expression by treatment with TZDs inhibited the expression of caspase 3 in IL-1beta/IFN-gamma-induced NIT-cells.	Thiazolidinediones	72-76	interleukin 1 beta	Mus musculus	118-126
23391392-2	2013	Doxycycline treatment induced rapid, abundant, and reversible IL-1beta production, influx of neutrophils and macrophages, and conspicuous and persistent lymphangiogenesis, but surprisingly no angiogenesis.	Doxycycline	0-11	interleukin 1 beta	Mus musculus	62-70
23206318-6	2013	Ethanol treatment of brain slice culture released HMGB1 into the media and induced the proinflammatory cytokine, interleukin-1 beta (IL-1beta).	Ethanol	0-7	interleukin 1 beta	Mus musculus	133-141
23206318-7	2013	Neutralizing antibodies to HMGB1 and small inhibitory mRNA to HMGB1 or TLR4 blunted ethanol induction of IL-1beta.	Ethanol	84-91	interleukin 1 beta	Mus musculus	105-113
23206318-8	2013	CONCLUSIONS: Ethanol-induced HMGB1/TLR signaling contributes to induction of the proinflammatory cytokine, IL-1beta.	Ethanol	13-20	interleukin 1 beta	Mus musculus	107-115
23416190-8	2013	Finally, daily treatment with HP 24 ameliorated the outcome of DSS-induced colitis in mice, significantly reducing colonic MPO activity and IL-1beta tissue levels.	Hematoporphyrins	30-32	interleukin 1 beta	Mus musculus	140-148
23180366-5	2013	In addition, pretreatment with limonene inhibited inflammatory cells and proinflammatory cytokines including tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 in BALF.	Limonene	31-39	interleukin 1 beta	Mus musculus	138-155
22921586-6	2013	Additionally, efflux of intracellular potassium, lysosomal rupture, and oxygen radical (ROS) production are crucial for caspase-1 processing and IL-1beta secretion by TDB.	Potassium	38-47	interleukin 1 beta	Mus musculus	145-153
22921586-6	2013	Additionally, efflux of intracellular potassium, lysosomal rupture, and oxygen radical (ROS) production are crucial for caspase-1 processing and IL-1beta secretion by TDB.	Reactive Oxygen Species	72-86	interleukin 1 beta	Mus musculus	145-153
22921586-6	2013	Additionally, efflux of intracellular potassium, lysosomal rupture, and oxygen radical (ROS) production are crucial for caspase-1 processing and IL-1beta secretion by TDB.	Reactive Oxygen Species	88-91	interleukin 1 beta	Mus musculus	145-153
23661518-13	2013	CONCLUSIONS: These results indicate that blocking the activity of TGF-beta/Smad pathway by specific inhibitor SB431542 of ALK5 promoted the releaser of large amounts of TNF-alpha, IL-1beta and other pro-inflammatory cytokines from the lung tissue of mice sustaining acute lung injury (ALI).	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	110-118	interleukin 1 beta	Mus musculus	180-188
23054333-8	2013	Oral pretreatment with anethole in mice inhibited paw oedema, mechanical pernociception, myelopewroxidase activity, TNF-alpha, IL-1beta and IL-17 levels in acute and persistent inflammation models.	anethole	23-31	interleukin 1 beta	Mus musculus	127-135
23499680-4	2013	Our results showed that ETH inhibited LPS-induced TNF-alpha and IL-6 release in a dose-dependent manner, and decreased TNF-alpha, IL-1beta, IL-6 and iNOS mRNA production.	1-(4-ethoxyphenyl)-3-(4-nitrophenyl)-prop-2-en-1-one	24-27	interleukin 1 beta	Mus musculus	130-138
23427328-0	2013	Dietary xylooligosaccharide downregulates IFN-gamma and the low-grade inflammatory cytokine IL-1beta systemically in mice.	xylooligosaccharide	8-27	interleukin 1 beta	Mus musculus	92-100
23460746-7	2013	Additionally, mitochondrial reactive oxygen species induced by Brucella were implicated in IL-1beta production.	Reactive Oxygen Species	28-51	interleukin 1 beta	Mus musculus	91-99
23427328-5	2013	In vitro treatment of blood with propionate significantly decreased Il1beta (P &lt; 0.01), Ifngamma (P &lt; 0.01), and interleukin 18 (Il18) (P &lt; 0.001) expression, supporting our hypothesis that increased production of short-chain fatty acids (SCFAs) in the gut, which are transported across the intestine and into the systemic compartments, results in downregulation of low-grade inflammatory cytokines.	Propionates	33-43	interleukin 1 beta	Mus musculus	68-75
23200185-10	2013	WBM supplementation, however, did induce changes in other aspects of the immune response: it significantly increased the production of T-helper type 2 cytokines IL-4 and IL-10 in uninfected mice and pro-inflammatory cytokines IL-1beta and TNF-alpha in infected mice.	2,3-diphenyl-5-[(1H-pyrazol-3-yl)amino]pyrazolo[1,5-a]pyrimidin-7(4H)-one	0-3	interleukin 1 beta	Mus musculus	226-234
23620183-2	2013	At higher concentrations, Escherichia coli-type hexa-acylated lipid A 506, Salmonella-type hepta-acylated lipid A 516, the lipid A precursor lipid IVa and monophosphoryl lipid A induced similar levels of production of the MyD88-dependent cytokine IL-1beta although their potencies varied, whereas the maximum production of the MyD88-independent cytokine RANTES induced by lipid IVa was less than 50% that of other lipid A compounds.	monophosphoryl	155-169	interleukin 1 beta	Mus musculus	247-255
23620183-3	2013	A maximum level of NF-kappaB activation, which is involved in IL-1beta gene transcription, was also induced to a similar level by these four lipid A compounds, while the maximum level of IFN-beta promoter activity induced during MyD88-independent signaling was also less than 50% for lipid IVa stimulation compared with other lipid A compounds.	Lipid A	141-148	interleukin 1 beta	Mus musculus	62-70
23360889-3	2013	Surfactin significantly inhibited excessive production of the pro-inflammatory mediators TNF-alpha, IL-1beta, IL-6, monocyte chemoattractant protein-1 (MCP-1), prostaglandin E2 (PGE2), nitric oxide (NO) and reactive oxygen species (ROS), and suppressed the expression of matrix metalloproteinase-9 (MMP-9), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2).	surfactin peptide	0-9	interleukin 1 beta	Mus musculus	100-108
23428419-8	2013	Further, we found that ATP-induced IL-1beta and IL-18 release from LPS-primed BMDCs was suppressed by pretreatment with P2X7 antagonist A438079 or P2X4 antagonist TNP-ATP.	Adenosine Triphosphate	23-26	interleukin 1 beta	Mus musculus	35-43
23353895-6	2013	RESULTS: URFE supplementation reduced HFD-induced atherosclerotic lesion formation which was correlated with decreased levels of lipids, lipid peroxides, and inflammatory mediators (TNF-alpha, IL-1beta, and nitric oxide) in sera as well as suppression of inflammatory gene in aortic tissues.	urfe	9-13	interleukin 1 beta	Mus musculus	193-201
23428419-8	2013	Further, we found that ATP-induced IL-1beta and IL-18 release from LPS-primed BMDCs was suppressed by pretreatment with P2X7 antagonist A438079 or P2X4 antagonist TNP-ATP.	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine	136-143	interleukin 1 beta	Mus musculus	35-43
23428419-10	2013	Chelation of intracellular Ca(2+) also caused suppression of ATP-induced IL-1beta and IL-18 release.	Adenosine Triphosphate	61-64	interleukin 1 beta	Mus musculus	73-81
23428419-8	2013	Further, we found that ATP-induced IL-1beta and IL-18 release from LPS-primed BMDCs was suppressed by pretreatment with P2X7 antagonist A438079 or P2X4 antagonist TNP-ATP.	picric acid	163-166	interleukin 1 beta	Mus musculus	35-43
23428419-8	2013	Further, we found that ATP-induced IL-1beta and IL-18 release from LPS-primed BMDCs was suppressed by pretreatment with P2X7 antagonist A438079 or P2X4 antagonist TNP-ATP.	Adenosine Triphosphate	167-170	interleukin 1 beta	Mus musculus	35-43
23072534-10	2013	The up-regulation of TNF-alpha, IL-1beta and IL-6 following 5-FU treatment was also attenuated by ramosetron.	Fluorouracil	60-64	interleukin 1 beta	Mus musculus	32-40
23072534-10	2013	The up-regulation of TNF-alpha, IL-1beta and IL-6 following 5-FU treatment was also attenuated by ramosetron.	ramosetron	98-108	interleukin 1 beta	Mus musculus	32-40
23370301-5	2013	C-34 also significantly downregulated the secretion of TNF-alpha, IL-1-beta and IL-6 by murine splenocytes and THP-1 cells against LPS induced levels.	Carbon	0-1	interleukin 1 beta	Mus musculus	66-75
23368428-8	2013	The accumulation of neutrophils and the concentrations of TNF-alpha, IL-1beta, IL-6, and MPO in BAL fluids were also effectively inhibited by pravastatin.	Pravastatin	142-153	interleukin 1 beta	Mus musculus	69-77
23339930-6	2013	The changes 8 h after TPA treatment probably reflected transcriptional regulation, and the genes were divided into three groups, up-regulated (IL-6, MCP-1, HO-1 and SOCS3), unregulated (IL-1beta, TNF-alpha and IL-10) and down-regulated (RANTES) genes.	Tetradecanoylphorbol Acetate	22-25	interleukin 1 beta	Mus musculus	186-194
23339930-7	2013	TPA-induced gene expression of cytokines, except for RANTES, peaked at 8 h and significantly declined in the late phase in control mice, while the expression of IL-1beta and TNF-alpha did not decline in the late phase in the diabetic mice.	Tetradecanoylphorbol Acetate	0-3	interleukin 1 beta	Mus musculus	161-169
23339930-9	2013	These findings suggested that STZ-induced diabetes affected the transcriptional and post-transcriptional control of TPA-induced inflammation, and greater mRNA levels of IL-1beta and TNF-alpha in the late phase were probably responsible for the diabetes-enhanced inflammation.	Streptozocin	30-33	interleukin 1 beta	Mus musculus	169-177
23277090-8	2013	Twenty-four hours post-injection (0.33 mg/kg LPS or Saline) we found a LPS-induced upregulation of whole brain TNFalpha, IL-1beta, and IL-10 mRNA, and increased IL-1beta and IL-6 in the spleen and liver; these effects were not attenuated by VWR.	Sodium Chloride	52-58	interleukin 1 beta	Mus musculus	121-129
23277090-8	2013	Twenty-four hours post-injection (0.33 mg/kg LPS or Saline) we found a LPS-induced upregulation of whole brain TNFalpha, IL-1beta, and IL-10 mRNA, and increased IL-1beta and IL-6 in the spleen and liver; these effects were not attenuated by VWR.	Sodium Chloride	52-58	interleukin 1 beta	Mus musculus	161-169
23489421-10	2013	Clodronate administration significantly reduced Gr1(+) cell infiltration and local IL-1beta levels.	Clodronic Acid	0-10	interleukin 1 beta	Mus musculus	83-91
23489421-11	2013	In vitro experiments confirmed that A438079 or apyrase treatment prevented the increase in IL-1beta that was evoked by macrophage and DC incubation with CrO and ATP.	Croton Oil	153-156	interleukin 1 beta	Mus musculus	91-99
23489421-11	2013	In vitro experiments confirmed that A438079 or apyrase treatment prevented the increase in IL-1beta that was evoked by macrophage and DC incubation with CrO and ATP.	Adenosine Triphosphate	161-164	interleukin 1 beta	Mus musculus	91-99
23391521-7	2013	Additionally, there was significant upregulation of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) expression in the striata of MPTP injected mice compared to saline controls.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	155-159	interleukin 1 beta	Mus musculus	96-114
23454767-4	2013	MFGE8 inhibited necrotic cell-induced and ATP-dependent IL-1beta production by macrophages through mediation of integrin beta(3) and P2X7 receptor interactions in primed cells.	Adenosine Triphosphate	42-45	interleukin 1 beta	Mus musculus	56-64
23315010-9	2013	Pro-inflammatory cytokines, such as tumor necrosis factor alpha, interleukin-1beta, inducible nitric oxide synthase, were increased upon AlCl3 administration.	Aluminum Chloride	137-142	interleukin 1 beta	Mus musculus	65-82
23274091-10	2013	Furthermore, treatment with GFO significantly inhibited the dextran sulfate sodium-induced increase in the mRNA expression of interleukin-1beta.	2-(4-tert-butylphenyl)-5-[(quinolin-2-ylamino)methyl]-6H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one	28-31	interleukin 1 beta	Mus musculus	126-143
23274091-10	2013	Furthermore, treatment with GFO significantly inhibited the dextran sulfate sodium-induced increase in the mRNA expression of interleukin-1beta.	Dextran Sulfate	60-82	interleukin 1 beta	Mus musculus	126-143
23510834-8	2013	Compared with the paraquat poisoning group, the thalidomide treatment groups had significantly decreased levels of TNF-alpha, IL-1beta, IL-6, NF-kappaB mRNA, and nuclear NF-kappaB p65 and wet/dry ratios of the lung (P &lt; 0.05), and the 150 mg/kg thalidomide treatment group showed the most significant decrease in the levels of TNF-alpha, IL-1beta, IL-6, NF-kappaB mRNA, and nuclear NF-kappaB p65.	Thalidomide	48-59	interleukin 1 beta	Mus musculus	126-134
23510834-8	2013	Compared with the paraquat poisoning group, the thalidomide treatment groups had significantly decreased levels of TNF-alpha, IL-1beta, IL-6, NF-kappaB mRNA, and nuclear NF-kappaB p65 and wet/dry ratios of the lung (P &lt; 0.05), and the 150 mg/kg thalidomide treatment group showed the most significant decrease in the levels of TNF-alpha, IL-1beta, IL-6, NF-kappaB mRNA, and nuclear NF-kappaB p65.	Thalidomide	48-59	interleukin 1 beta	Mus musculus	341-349
23454767-5	2013	Itgb3 deficiency in macrophages abrogated the inhibitory effect of MFGE8 on ATP-induced IL-1beta production.	Adenosine Triphosphate	76-79	interleukin 1 beta	Mus musculus	88-96
23263992-8	2013	Chronic treatment with SDG also affected the body weight of mice and IL-6, IL1beta levels in the frontal cortex.	secoisolariciresinol diglucoside	23-26	interleukin 1 beta	Mus musculus	75-82
23261590-5	2013	In addition, we found that neoechinulin A significantly suppressed the production of neurotoxic inflammatory mediator tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and prostaglandin E2 (PGE2) in activated BV-2 cells.	neoechinulin A	27-41	interleukin 1 beta	Mus musculus	160-177
23261590-5	2013	In addition, we found that neoechinulin A significantly suppressed the production of neurotoxic inflammatory mediator tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and prostaglandin E2 (PGE2) in activated BV-2 cells.	neoechinulin A	27-41	interleukin 1 beta	Mus musculus	179-187
23510834-7	2013	RESULTS: Compared with the negative control group, the paraquat poisoning group had significantly increased levels of TNF-alpha, IL-1beta, IL-6, NF-kappaB mRNA, and nuclear NF-kappaB p65 and wet/dry ratio of the lung (P &lt; 0.05).	Paraquat	55-63	interleukin 1 beta	Mus musculus	129-137
23288154-3	2013	METHODS AND RESULTS: IL-1beta mRNA and protein levels were significantly elevated in abdominal aortas of 8- to 12-week-old male C57Bl/6 mice after elastase aortic perfusion (wild-type [WT]) compared with saline perfusion.	Sodium Chloride	204-210	interleukin 1 beta	Mus musculus	21-29
23297396-6	2013	PIP5Kalpha knockdown significantly suppressed induction of inflammatory mediators, including IL-6, IL-1beta, and nitric oxide, by lipopolysaccharide.	pip5kalpha	0-10	interleukin 1 beta	Mus musculus	99-107
23266381-7	2013	In contrast, pre-treatment with DPC-333 effectively suppressed IL-1beta and IFN-gamma in mice in vivo or in vitro.	BMS561392	32-39	interleukin 1 beta	Mus musculus	63-71
23399258-3	2013	GM reduced mechanical allodynia and the levels of interleukin 1-beta (IL-1beta) in spinal cord and nerve in the partial sciatic nerve ligation (PSNL) model.	(1-6)-alpha-glucomannan	0-2	interleukin 1 beta	Mus musculus	50-68
23399258-3	2013	GM reduced mechanical allodynia and the levels of interleukin 1-beta (IL-1beta) in spinal cord and nerve in the partial sciatic nerve ligation (PSNL) model.	(1-6)-alpha-glucomannan	0-2	interleukin 1 beta	Mus musculus	70-78
23399258-4	2013	Systemic treatment with GM inhibited the nociception induced by intraplantar injection of glutamate and by intrathecal injection of N-methyl-d-aspartic acid (NMDA), (+-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (trans-ACPD), tumour necrosis factor alpha (TNF-alpha) and IL-1beta.	(1-6)-alpha-glucomannan	24-26	interleukin 1 beta	Mus musculus	277-285
23182953-4	2013	TEGDMA reduced LPS-induced release of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), whereas HEMA only reduced IL-1beta release.	triethylene glycol dimethacrylate	0-6	interleukin 1 beta	Mus musculus	38-55
23182953-4	2013	TEGDMA reduced LPS-induced release of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), whereas HEMA only reduced IL-1beta release.	triethylene glycol dimethacrylate	0-6	interleukin 1 beta	Mus musculus	57-65
23009282-10	2013	Compared with the dextran sulphate sodium alone group, the methotrexate group showed down-regulation of IL-1beta at the mRNA level, while the anti-alpha(2) antibody group displayed decreased protein expression of iNOS and IL-1beta.	Methotrexate	59-71	interleukin 1 beta	Mus musculus	104-112
23123663-7	2013	Coumermycin A1 also abrogated RANKL-induced expression of interleukin-1beta, tumor necrosis factor-alpha, and inducible nitric oxide synthase in mouse BMMs.	coumermycin	0-14	interleukin 1 beta	Mus musculus	58-104
23318584-2	2013	Here we show that nitric oxide (NO) inhibited the NLRP3-mediated ASC pyroptosome formation, caspase-1 activation and IL-1beta secretion in myeloid cells from both mice and humans.	Nitric Oxide	18-30	interleukin 1 beta	Mus musculus	117-125
23318584-4	2013	Depletion of iNOS resulted in increased accumulation of dysfunctional mitochondria in response to LPS and ATP, which was responsible for the increased IL-1beta production and caspase-1 activation.	Adenosine Triphosphate	106-109	interleukin 1 beta	Mus musculus	151-159
22516481-8	2013	In addition, propofol pretreatment significantly inhibited the upregulated expression of high-mobility group box-1 (HMGB1) protein, TLR4 and its downstream signaling molecules--myeloid differentiation factor 88 (MyD88) and nuclear factor kappa-B (NF-kappaB)--in gastric mucosa, while suppressing the increased release of tumor neurosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in serum.	Propofol	13-21	interleukin 1 beta	Mus musculus	365-382
22516481-8	2013	In addition, propofol pretreatment significantly inhibited the upregulated expression of high-mobility group box-1 (HMGB1) protein, TLR4 and its downstream signaling molecules--myeloid differentiation factor 88 (MyD88) and nuclear factor kappa-B (NF-kappaB)--in gastric mucosa, while suppressing the increased release of tumor neurosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in serum.	Propofol	13-21	interleukin 1 beta	Mus musculus	384-392
22378344-5	2013	The tissue levels of interleukin-1beta and tumor necrosis factor-alpha, myeloperoxidase activity and the number of apoptotic cells were increased in the colon of DSS-challenged Cnlp(-/-) mice.	Dextran Sulfate	162-165	interleukin 1 beta	Mus musculus	21-70
23131135-9	2013	Also, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-1beta, and prostaglandin E(2) (PGE(2)) secretion were decreased by CPS in LPS-stimulated macrophages.	capillarisin	131-134	interleukin 1 beta	Mus musculus	61-69
23137955-7	2013	The nephroprotective activities of polydatin was not only due to the effects on remarkably attenuating the oxidative stress induced by uric acid, but also on markedly suppressing the oxidative stress-related inflammatory cascade, including decreasing the expressions of NF-kappaB p65, COX-2 and iNOS proteins and inhibiting the productions of TNF-alpha, PGE(2) and IL-1beta.	polydatin	35-44	interleukin 1 beta	Mus musculus	365-373
22987396-2	2013	Here we show that both TLR2 and palmitic acid are required for activation of the inflammasome, interleukin (IL)-1alpha, and IL-1beta, resulting in the progression of NASH.	Palmitic Acid	32-45	interleukin 1 beta	Mus musculus	124-132
22987396-11	2013	In the presence of TLR2 ligand, palmitic acid did induce caspase-1 activation and release of IL-1alpha and IL-1beta in Kupffer cells; however, these effects were not observed in HSCs.	Palmitic Acid	32-45	interleukin 1 beta	Mus musculus	107-115
22987396-12	2013	In vivo, WT mice on the CDAA diet showed increased caspase-1 activation in the liver and elevated serum levels of IL-1alpha and IL-1beta levels, which were suppressed in TLR2(-/-) mice.	CDAA	24-28	interleukin 1 beta	Mus musculus	128-136
22948514-7	2013	In addition, curcumin inhibited intrahepatic expression of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 protein.	Curcumin	13-21	interleukin 1 beta	Mus musculus	100-122
22869199-6	2013	Naloxone inhibited microglial activation and decreased the release of IL-1beta and TNF-alpha but could not prevent photoreceptors from undergoing apoptosis.	Naloxone	0-8	interleukin 1 beta	Mus musculus	70-78
23261361-6	2013	RESULTS: Our present study has shown that lipopolysaccharide (LPS) and cyclosporin A (CsA) could increase or decrease the gene and protein expressions of TNF-alpha and IL-1beta respectively.	Cyclosporine	71-84	interleukin 1 beta	Mus musculus	168-176
23261361-6	2013	RESULTS: Our present study has shown that lipopolysaccharide (LPS) and cyclosporin A (CsA) could increase or decrease the gene and protein expressions of TNF-alpha and IL-1beta respectively.	Cyclosporine	86-89	interleukin 1 beta	Mus musculus	168-176
23261361-7	2013	TCA (0.25g/kg, 0.125g/kg) could recover the suppressed expressions of TNF-alpha and IL-1beta and increase the ratio of CD4(+)/CD8(+).	Taurocholic Acid	0-3	interleukin 1 beta	Mus musculus	84-92
23261361-8	2013	In vitro, TCA (15mug/mL) could inhibit the increased production of TNF-alpha and IL-1beta; TCA (0.15mug/mL-15mug/mL) could inhibit the increased gene expressions of IL-1beta and TNF-alpha.	Taurocholic Acid	10-13	interleukin 1 beta	Mus musculus	81-89
23261361-8	2013	In vitro, TCA (15mug/mL) could inhibit the increased production of TNF-alpha and IL-1beta; TCA (0.15mug/mL-15mug/mL) could inhibit the increased gene expressions of IL-1beta and TNF-alpha.	Taurocholic Acid	91-94	interleukin 1 beta	Mus musculus	165-173
23261361-9	2013	TCA (0.15mug/mL) could recover the suppressed expressions of TNF-alpha and IL-1beta.	Taurocholic Acid	0-3	interleukin 1 beta	Mus musculus	75-83
23261361-10	2013	CONCLUSION: The function of immunoregulation of TCA may be accomplished through modulating the gene and protein expressions of TNF-alpha and IL-1beta and elevating CD4(+)/CD8(+) T-cell ratio.	Taurocholic Acid	48-51	interleukin 1 beta	Mus musculus	141-149
22290536-10	2013	In fact, cAMP inhibited ET-1-stimulated TNF-alpha and IL-1beta expressions in adipocytes.	Cyclic AMP	9-13	interleukin 1 beta	Mus musculus	54-62
23440625-4	2013	Both polyphenols proved to have anti-inflammatory activity as evidenced by the decreased nitric oxide (NO), cytokines (IL-1beta , IL-6, and IL-10) and prostaglandin E2 (PGE(2)) levels in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages.	Polyphenols	5-16	interleukin 1 beta	Mus musculus	119-127
23270759-5	2013	In addition, britanin reduced the release of pro-inflammatory cytokines, such as TNF-alpha, IL-1beta, and IL-6.	Britanin	13-21	interleukin 1 beta	Mus musculus	92-100
23352443-4	2013	The results showed that gossypol significantly inhibited the production of LPS-induced TNF-alpha, IL-6 and IL-1beta both in vitro and vivo.	Gossypol	24-32	interleukin 1 beta	Mus musculus	107-115
23262358-5	2013	Frenatin 2D (20 mug/ml) significantly stimulated production of the proinflammatory cytokines TNF-alpha (P&lt;0.05) and IL-1beta (P&lt;0.01) by mouse peritoneal macrophages but the peptide did not potentiate the stimulation produced by lipopolysaccharide (LPS).	frenatin 2d	0-11	interleukin 1 beta	Mus musculus	119-127
23146835-9	2013	The observed increases in multiantennary N-glycans and in outer branch fucosylation and sialylation were associated with the up-regulation of genes involved in glycosylation in the liver, which is the main producer of serum proteins, and with an increase in the key proinflammatory serum cytokines IL-1beta, IL-6, and TNFalpha, which can regulate the expression of glycosylation genes.	n-glycans	41-50	interleukin 1 beta	Mus musculus	298-306
23220159-7	2013	Treatment of mice with carvacrol at 50 and 100mg/kg attenuated the paw edema and reduced the IL-1beta and PGE(2), but not TNF-alpha, local levels.	carvacrol	23-32	interleukin 1 beta	Mus musculus	93-101
23201088-7	2013	RESULTS: Shikonin administration significantly reduced serum amylase and lipase activities, pancreatic histological scores, TNF-alpha, IL-1beta, IL-6 levels, MPO activity and NF-kappaB activity.	shikonin	9-17	interleukin 1 beta	Mus musculus	135-143
23668020-10	2013	IL-1beta in serum in the TCM group and the TCM WM group were lower than that of the hydroxychloroquine group (P &lt; 0.05), but without statistical significance compared with the normal group.	Hydroxychloroquine	84-102	interleukin 1 beta	Mus musculus	0-8
23220159-8	2013	Similarly, carvacrol (100mg/kg) reduced the COX-2 and IL-1beta mRNA expression.	carvacrol	11-20	interleukin 1 beta	Mus musculus	54-62
23220159-11	2013	The present results suggest that carvacrol causes anti-inflammatory effects by reducing the production of inflammatory mediators, such as IL-1beta and prostanoids, possibly through the induction of IL-10 release.	carvacrol	33-42	interleukin 1 beta	Mus musculus	138-146
22729592-6	2013	Curcumin supplementation increased plasma concentrations of angiogenic factors angiogenin (p &lt; 0.05), basic fibroblast growth factor (p &lt; 0.05) and vascular endothelial growth factor (p &lt; 0.05), as well as inflammatory cytokines interleukin-1beta (p &lt; 0.05) and monocyte chemotactic protein-1 (p &lt; 0.05), compared to the controls.	Curcumin	0-8	interleukin 1 beta	Mus musculus	238-255
24000330-7	2013	The expression of IL-6 and IL-1beta was significantly increased under 10 mM glucose in the presence of NT, while IL-1beta and IL-12 expression significantly decreased under inflammatory and hyperglycemic conditions.	Glucose	76-83	interleukin 1 beta	Mus musculus	27-35
23084372-3	2013	Adjudin significantly inhibited LPS-induced IL-6 release and IL-6, IL-1beta, TNF-alpha expression in BV2 microglial cells.	1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide	0-7	interleukin 1 beta	Mus musculus	67-75
23344054-5	2013	Anthocyanins also downregulated excessive expression of inducible NO synthase, cyclooxygenase-2, TNF-alpha, and IL-1beta in LPS-stimulated BV2 cells.	Anthocyanins	0-12	interleukin 1 beta	Mus musculus	112-120
24228606-9	2013	30 mg/kg of TMP treatment reduced the up-regulation of TNF-alpha, IL-1beta and COX-2 mRNA in the spinal tissue at four hours after the SCI induction.	tetramethylpyrazine	12-15	interleukin 1 beta	Mus musculus	66-74
23075678-3	2013	Chronic (for 6 months from the age of 6 to 12 months) oral administration of ferulic acid at a dose of 5.3 mg/kg/day significantly enhanced the performance in novel-object recognition task, and reduced amyloid deposition and interleukin-1 beta (IL-1beta) levels in the frontal cortex.	ferulic acid	77-89	interleukin 1 beta	Mus musculus	225-243
23026222-7	2013	In GA-treated tMCAo mice, microglial pro-inflammatory cytokines IL-1beta and TNFalpha were significantly decreased without modification of microglial/macrophage cell density, cytokine secretion, neurological deficit or infarct volume at D3, or modification of neurological deficit, neurogenesis or infarct volume at D7.	Glatiramer Acetate	3-5	interleukin 1 beta	Mus musculus	64-72
23026222-7	2013	In GA-treated tMCAo mice, microglial pro-inflammatory cytokines IL-1beta and TNFalpha were significantly decreased without modification of microglial/macrophage cell density, cytokine secretion, neurological deficit or infarct volume at D3, or modification of neurological deficit, neurogenesis or infarct volume at D7.	tmcao	14-19	interleukin 1 beta	Mus musculus	64-72
23344054-4	2013	Our results showed that anthocyanins significantly inhibited LPS-induced pro-inflammatory mediators, such as nitric oxide (NO) and prostaglandin E(2), and pro-inflammatory cytokines including tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta, without significant cytotoxicity.	Anthocyanins	24-36	interleukin 1 beta	Mus musculus	230-252
23127653-11	2013	Magnolol inhibited the expression of TNF-alpha, IL-6 and IL-1beta in LPS-stimulated RAW264.7 cells in a dose-dependent manner.	magnolol	0-8	interleukin 1 beta	Mus musculus	57-65
23302642-7	2013	Ginsenoside Rh1 also inhibited the expressions of PPAR-gamma, C/EBP-alpha, fatty acid synthase, adipocyte fatty acid-binding protein, as well as F4/80, CD68, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta in DIO mice by real time PCR analysis.	ginsenoside Rh1	0-15	interleukin 1 beta	Mus musculus	217-225
23020072-8	2013	RESULTS:   Dasatinib and LCB 03-0110 suppressed the symptoms of ACD such as ear swelling, increase in epidermal thickness and synthesis of inflammatory cytokines (i.e. interleukin-1beta, tumour necrosis factor-alpha and interferon-gamma) in a dose-dependent manner.	Dasatinib	11-20	interleukin 1 beta	Mus musculus	168-215
24009860-6	2013	THC effectively suppressed the LPS-induced induction of pro-inflammatory mediators such as NO, TNF-alpha, and IL-1beta.	Dronabinol	0-3	interleukin 1 beta	Mus musculus	110-118
22889120-6	2013	IL-1beta, IFN-gamma, keratinocyte-derived chemokine and macrophage inflammatory protein-2 were markedly increased in the colon from DSS-treated B1(-/-)  compared with DSS-treated WT mice.	Dextran Sulfate	132-135	interleukin 1 beta	Mus musculus	0-8
23026294-7	2013	Septic mice that were pretreated with the selective NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) were found to have a decreased liberation of proinflammtory cytokines such as TNF-alpha, IL-1beta, IL-6, or IFN-gamma.	pyrrolidine dithiocarbamic acid	72-99	interleukin 1 beta	Mus musculus	196-204
23839341-6	2013	The inhibition of NLRP3 expression by pirfenidone attenuated the expression of IL-1beta and IL-1beta-induced inflammatory and profibrotic responses.	pirfenidone	38-49	interleukin 1 beta	Mus musculus	79-87
23839341-6	2013	The inhibition of NLRP3 expression by pirfenidone attenuated the expression of IL-1beta and IL-1beta-induced inflammatory and profibrotic responses.	pirfenidone	38-49	interleukin 1 beta	Mus musculus	92-100
24151519-6	2013	Heparin treatment of B/W mice reduced the in vivo expression of CCR2, IL1 beta , and TLR7 compared to untreated B/W mice.	Heparin	0-7	interleukin 1 beta	Mus musculus	70-78
24016270-0	2013	A neutralization scFv antibody against IL-1beta isolated from a NIPA-based bacterial display library.	N-isopropylacrylamide	64-68	interleukin 1 beta	Mus musculus	39-47
23114643-6	2013	Co-administration of nilotinib and doxorubicin to mice decreased the expression of IL-1beta RNA in the liver and suppressed the level of IL-6 protein in the serum compared with mice that were injected with doxorubicin alone.	nilotinib	21-30	interleukin 1 beta	Mus musculus	83-91
23114643-6	2013	Co-administration of nilotinib and doxorubicin to mice decreased the expression of IL-1beta RNA in the liver and suppressed the level of IL-6 protein in the serum compared with mice that were injected with doxorubicin alone.	Doxorubicin	35-46	interleukin 1 beta	Mus musculus	83-91
23026294-7	2013	Septic mice that were pretreated with the selective NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) were found to have a decreased liberation of proinflammtory cytokines such as TNF-alpha, IL-1beta, IL-6, or IFN-gamma.	pyrrolidine dithiocarbamic acid	101-105	interleukin 1 beta	Mus musculus	196-204
23107827-9	2013	5-FU-induced epithelial damage increased the MPO activity (neutrophil number) and the level of pro-inflammatory cytokines (IL-4, TNF-alpha, IL-1beta and CXCL-8) in the duodenum.	Fluorouracil	0-4	interleukin 1 beta	Mus musculus	140-148
24223056-5	2013	Preliminary mechanistic studies demonstrated that CISCFE decreased the MDA level via increasing the activities of anti-oxidant enzymes (SOD, GPx, and GRd), attenuated the productions of NF- kappa B, TNF- alpha , IL-1 beta , IL-6, PGE2 and NO, and suppressed the activities of iNOS and COX-2.	ciscfe	50-56	interleukin 1 beta	Mus musculus	212-221
23781267-10	2013	Artepillin C exerted strong antioxidant activity, significantly inhibited the production of ROS, RNS, NO, and cytokine IL-1 beta , IL-3, IL-4, IL-5, IL-9, IL-12p40, IL-13, IL-17, TNF- alpha , G-CSF, GM-CSF, MCP-1, MIP-1 alpha , MIP-1 beta , RANTES, and KC, and markedly blocked NF- kappa B expression in stimulated RAW264.7 macrophages.	artepillin C	0-12	interleukin 1 beta	Mus musculus	119-128
23690856-6	2013	The LPS-induced mRNA level of iNOS, COX-2, IL-1 beta , and TNF- alpha was reduced by the acute treatment with glucosylceramide in adult mice.	Glucosylceramides	110-126	interleukin 1 beta	Mus musculus	43-52
24348718-4	2013	NPM-9 also suppressed IL-4 and IL-1beta production in splenocytes but prevented only TMA-induced IL-1beta production in inflamed ears.	4,4-dimethylcholesta-8,14-dien-3-ol	85-88	interleukin 1 beta	Mus musculus	97-105
23401705-5	2013	Next we found that EECP could significantly inhibit the production of NO, IL-1beta, and IL-6 in lipopolysaccharide- (LPS-) stimulated RAW 264.7 cells and suppress mRNA expression of iNOS, IL-1beta, and IL-6 in a time- and dose-dependent manner.	eecp	19-23	interleukin 1 beta	Mus musculus	74-82
23401705-5	2013	Next we found that EECP could significantly inhibit the production of NO, IL-1beta, and IL-6 in lipopolysaccharide- (LPS-) stimulated RAW 264.7 cells and suppress mRNA expression of iNOS, IL-1beta, and IL-6 in a time- and dose-dependent manner.	eecp	19-23	interleukin 1 beta	Mus musculus	188-196
23737837-3	2013	Embryos exposed to nicotine (1 mM) exhibited severe morphological anomalies and apoptotic cell death, as well as increased levels of TNF- alpha , IL-1 beta , and caspase 3 mRNAs, and lipid peroxidation.	Nicotine	19-27	interleukin 1 beta	Mus musculus	146-155
23078031-6	2013	Exposure to CS also induced neutrophil and macrophage infiltration and expression of inflammatory cytokines (IL-1beta, tumour necrosis factor-alpha, IL-17), chemokines (monocyte chemoattractant protein-1) and mucin 5, subtypes A and C in the airways.	Cesium	12-14	interleukin 1 beta	Mus musculus	109-147
23017409-0	2013	Ginger extract and zingerone ameliorated trinitrobenzene sulphonic acid-induced colitis in mice via modulation of nuclear factor-kappaB activity and interleukin-1beta signalling pathway.	zingerone	19-28	interleukin 1 beta	Mus musculus	149-166
23017409-0	2013	Ginger extract and zingerone ameliorated trinitrobenzene sulphonic acid-induced colitis in mice via modulation of nuclear factor-kappaB activity and interleukin-1beta signalling pathway.	trinitrobenzene sulphonic acid	41-71	interleukin 1 beta	Mus musculus	149-166
23017409-6	2013	Network analysis showed that nuclear factor-kappaB (NF-kappaB) and interleukin-1beta (IL-1beta) were key molecules involved in the expression of ginger- and zingerone-affected genes.	zingerone	157-166	interleukin 1 beta	Mus musculus	67-84
23256797-6	2013	RESULTS: UA markedly rescued lethality, improved survival time and lung pathological changes, inhibited TNF-alpha, IL-6, IL-1beta, HMGB1 and NO, and increased IL-10 expression.	ursolic acid	9-11	interleukin 1 beta	Mus musculus	121-129
22915087-5	2013	Salidroside administered 1 h before LPS infusion significantly attenuated inflammatory cell infiltration, reduced the activity of myeloperoxidase in mammary tissue, and decreased the concentration of tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 in a dose-dependent manner.	rhodioloside	0-11	interleukin 1 beta	Mus musculus	229-251
23370667-6	2013	CD-101 significantly inhibited the production of inflammatory markers such as nitric oxide, cyclooxygenase-2, and pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6.	CD-101	0-6	interleukin 1 beta	Mus musculus	178-195
24250585-6	2013	It was shown that oxymatrine inhibited the productions of NO, PGE2, TNF-alpha, IL-1beta and IL-6, attenuated the mRNA levels of iNOS and COX-2, suppressed the phosphorylation of I-kappaBalpha in cytosol, decreased the nuclear levels of p65, and also blocked ERK, p38 and JNK pathway in LPS-stimulated BV2 microglial cells in a dose-dependent manner.	oxymatrine	18-28	interleukin 1 beta	Mus musculus	79-87
23139430-5	2013	Fenretinide also decreased IL-1beta, IL-6, and prostaglandin E2 proinflammatory cytokine levels in Raw 264.7 cells induced by A. actinomycetemcomitans.	Fenretinide	0-11	interleukin 1 beta	Mus musculus	27-35
23727645-3	2013	Furthermore, mRNA expression of interleukin-1beta in adipose tissue and serum levels of nonesterified fatty acids in mice administered L. plantarum OLL2712 were significantly lower than those in control mice.	Fatty Acids	102-113	interleukin 1 beta	Mus musculus	32-49
23215694-8	2013	CONCLUSIONS: beta-Sitosterol inhibited either myeloperoxidase and adenosine deaminase activity or IL-1beta and TNF-alpha levels.	gamma-sitosterol	13-28	interleukin 1 beta	Mus musculus	98-106
23090956-5	2013	Mice treated with LPS alone showed markedly increased plasma levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6, whereas mice that were also treated with GXM showed significantly lower plasma levels of these cytokines.	glucuronoxylomannan	193-196	interleukin 1 beta	Mus musculus	112-129
23090956-5	2013	Mice treated with LPS alone showed markedly increased plasma levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6, whereas mice that were also treated with GXM showed significantly lower plasma levels of these cytokines.	glucuronoxylomannan	193-196	interleukin 1 beta	Mus musculus	131-139
23569374-5	2013	In addition, the liposomal piroxicam formulation resulted in statistically stronger inhibition of pro-inflammatory mediators (ie, nitric oxide, tumor necrosis factor-alpha, interleukin-1beta, and prostaglandin E2) than piroxicam at an equivalent dose.	Piroxicam	27-36	interleukin 1 beta	Mus musculus	173-190
23221343-0	2013	Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1beta secretion.	Calcium Oxalate	0-15	interleukin 1 beta	Mus musculus	69-77
23221343-7	2013	These data demonstrated that CaOx crystals trigger IL-1beta-dependent innate immunity via the NLRP3/ASC/caspase-1 axis in intrarenal mononuclear phagocytes and directly damage tubular cells, leading to the release of the NLRP3 agonist ATP.	Adenosine Triphosphate	235-238	interleukin 1 beta	Mus musculus	51-59
23099324-5	2013	GW3965 was able to repress proinflammatory cytokine (TNF-alpha, IL-1beta, IL-6, and IL-12p40) expression in BMMs exposed to LPS alone; however, once BMMs entered the osteoclast lineage following RANKL priming, GW3965 no longer inhibited cytokine expression.	GW 3965	0-6	interleukin 1 beta	Mus musculus	64-72
22933241-2	2013	Several lines of evidence implicate NACHT, LRR, and PYD domains-containing protein 3 (NALP3) inflammasome-mediated production of interleukin 1 beta (IL-1beta) in the pathogenesis of clinical disorders ascribable to foreign particulate materials, including asbestos, silica, and urate crystals.	Silicon Dioxide	266-272	interleukin 1 beta	Mus musculus	129-147
22933241-2	2013	Several lines of evidence implicate NACHT, LRR, and PYD domains-containing protein 3 (NALP3) inflammasome-mediated production of interleukin 1 beta (IL-1beta) in the pathogenesis of clinical disorders ascribable to foreign particulate materials, including asbestos, silica, and urate crystals.	Silicon Dioxide	266-272	interleukin 1 beta	Mus musculus	149-157
22933241-2	2013	Several lines of evidence implicate NACHT, LRR, and PYD domains-containing protein 3 (NALP3) inflammasome-mediated production of interleukin 1 beta (IL-1beta) in the pathogenesis of clinical disorders ascribable to foreign particulate materials, including asbestos, silica, and urate crystals.	Uric Acid	278-283	interleukin 1 beta	Mus musculus	129-147
22933241-2	2013	Several lines of evidence implicate NACHT, LRR, and PYD domains-containing protein 3 (NALP3) inflammasome-mediated production of interleukin 1 beta (IL-1beta) in the pathogenesis of clinical disorders ascribable to foreign particulate materials, including asbestos, silica, and urate crystals.	Uric Acid	278-283	interleukin 1 beta	Mus musculus	149-157
22933241-8	2013	Importantly, using macrophages from mice deficient in components of the NALP3 inflammasome, we show PMMA-induced IL-1beta production is strictly dependent on these components.	Polymethyl Methacrylate	100-104	interleukin 1 beta	Mus musculus	113-121
22995661-10	2013	S-methylisothiourea treatment significantly decreased P aeruginosa infection with thermal injury pretreatment-induced lung injury, blood bacterial counts, pulmonary IL-1beta expression, and mortality in Tnfrsf1a(-/-) mice.	S-methylisothiopseudouronium	0-19	interleukin 1 beta	Mus musculus	165-173
23533300-10	2013	In addition, dexamethasone treatment reduced IL-1 beta.	Dexamethasone	13-26	interleukin 1 beta	Mus musculus	45-54
23129255-4	2013	The results obtained show that CLA was found to reduce the production of tumor necrosis factor-alpha, interleukin (IL)-1beta and prostaglandin E2 (PGE2), but had no effect on IL-6 production.	Linoleic Acids, Conjugated	31-34	interleukin 1 beta	Mus musculus	102-124
23768253-3	2013	Three flavones, 5-methoxy-6,7-methylenedioxyflavone (6), mosloflavone (7) and negletein (8), showed promising anti-inflammatory activity via inhibition of TNF-alpha and IL-1beta with IC50 values of 0.22, 0.71, 16.4 muM and 10.8, 7.8, 6.4 muM, respectively.	Flavones	6-14	interleukin 1 beta	Mus musculus	169-177
23781123-0	2013	Biphasic modulation of NOS expression, protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock: downstream regulation of COX-2, IL-1beta, TNF-alpha, IL-6, and HMGB1 expression.	Hydroxocobalamin	71-87	interleukin 1 beta	Mus musculus	174-182
23781123-5	2013	HOCbl/NOS/ NO regulation is reciprocally associated with lower 4 h expression of TNF-alpha, IL-1beta, COX-2, and lower circulating TNF-alpha, but not IL-6.	Hydroxocobalamin	0-5	interleukin 1 beta	Mus musculus	92-100
23028093-2	2013	Of 51 genes expressed in the Toll-like receptor (TLR) and RIG-I-like receptor (RLR) pathways, mRNA expression of 15 genes in RAW264.7 cells was attenuated by nicotine, of which mRNA expression of IL-6, TNF-alpha, and IL-1beta was confirmed to be attenuated in peritoneal macrophages.	Nicotine	158-166	interleukin 1 beta	Mus musculus	217-225
23737642-4	2013	In microglia and the microglia cell line EOC20, ATP advanced the TNF-alpha/IFN-gamma-induced dye coupling, probably through the induction of IL-1beta release.	Adenosine Triphosphate	48-51	interleukin 1 beta	Mus musculus	141-149
23970812-4	2013	Cuprizone increased GFAP, Iba-1, TNF- alpha , COX-2, IL-1 beta , and IFN- gamma expression, decreased expression of glutathione S-transferase pi (GSTpi), and damaged myelin in iNOS(-/-) mice.	Cuprizone	0-9	interleukin 1 beta	Mus musculus	53-62
23970812-5	2013	Sildenafil reduced Iba-1, IFN- gamma , and IL-1 beta levels but had no effect on the expression of GFAP, TNF- alpha , and COX-2 compared to the cuprizone group.	Sildenafil Citrate	0-10	interleukin 1 beta	Mus musculus	43-52
24072958-4	2013	In this study we examined ROS production and TNF- alpha , IL-1 beta inflammatory cytokines releasing, and the expression of MAPKs in BV-2 microglia cells treated with fluoride.	Fluorides	167-175	interleukin 1 beta	Mus musculus	58-67
23202296-3	2013	Here we show that two clinically used chemotherapeutic agents, gemcitabine (Gem) and 5-fluorouracil (5FU), activate the NOD-like receptor family, pyrin domain containing-3 protein (Nlrp3)-dependent caspase-1 activation complex (termed the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1beta (IL-1beta), which curtails anticancer immunity.	gemcitabine	63-74	interleukin 1 beta	Mus musculus	323-340
23202296-3	2013	Here we show that two clinically used chemotherapeutic agents, gemcitabine (Gem) and 5-fluorouracil (5FU), activate the NOD-like receptor family, pyrin domain containing-3 protein (Nlrp3)-dependent caspase-1 activation complex (termed the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1beta (IL-1beta), which curtails anticancer immunity.	gemcitabine	63-74	interleukin 1 beta	Mus musculus	342-350
23202296-3	2013	Here we show that two clinically used chemotherapeutic agents, gemcitabine (Gem) and 5-fluorouracil (5FU), activate the NOD-like receptor family, pyrin domain containing-3 protein (Nlrp3)-dependent caspase-1 activation complex (termed the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1beta (IL-1beta), which curtails anticancer immunity.	gemcitabine	76-79	interleukin 1 beta	Mus musculus	323-340
23202296-3	2013	Here we show that two clinically used chemotherapeutic agents, gemcitabine (Gem) and 5-fluorouracil (5FU), activate the NOD-like receptor family, pyrin domain containing-3 protein (Nlrp3)-dependent caspase-1 activation complex (termed the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1beta (IL-1beta), which curtails anticancer immunity.	gemcitabine	76-79	interleukin 1 beta	Mus musculus	342-350
23202296-3	2013	Here we show that two clinically used chemotherapeutic agents, gemcitabine (Gem) and 5-fluorouracil (5FU), activate the NOD-like receptor family, pyrin domain containing-3 protein (Nlrp3)-dependent caspase-1 activation complex (termed the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1beta (IL-1beta), which curtails anticancer immunity.	Fluorouracil	85-99	interleukin 1 beta	Mus musculus	323-340
23202296-3	2013	Here we show that two clinically used chemotherapeutic agents, gemcitabine (Gem) and 5-fluorouracil (5FU), activate the NOD-like receptor family, pyrin domain containing-3 protein (Nlrp3)-dependent caspase-1 activation complex (termed the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1beta (IL-1beta), which curtails anticancer immunity.	Fluorouracil	85-99	interleukin 1 beta	Mus musculus	342-350
23202296-3	2013	Here we show that two clinically used chemotherapeutic agents, gemcitabine (Gem) and 5-fluorouracil (5FU), activate the NOD-like receptor family, pyrin domain containing-3 protein (Nlrp3)-dependent caspase-1 activation complex (termed the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1beta (IL-1beta), which curtails anticancer immunity.	Fluorouracil	101-104	interleukin 1 beta	Mus musculus	323-340
23202296-3	2013	Here we show that two clinically used chemotherapeutic agents, gemcitabine (Gem) and 5-fluorouracil (5FU), activate the NOD-like receptor family, pyrin domain containing-3 protein (Nlrp3)-dependent caspase-1 activation complex (termed the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1beta (IL-1beta), which curtails anticancer immunity.	Fluorouracil	101-104	interleukin 1 beta	Mus musculus	342-350
23768253-3	2013	Three flavones, 5-methoxy-6,7-methylenedioxyflavone (6), mosloflavone (7) and negletein (8), showed promising anti-inflammatory activity via inhibition of TNF-alpha and IL-1beta with IC50 values of 0.22, 0.71, 16.4 muM and 10.8, 7.8, 6.4 muM, respectively.	5-Methoxy-6,7-methylenedioxyflavone	16-51	interleukin 1 beta	Mus musculus	169-177
23768253-3	2013	Three flavones, 5-methoxy-6,7-methylenedioxyflavone (6), mosloflavone (7) and negletein (8), showed promising anti-inflammatory activity via inhibition of TNF-alpha and IL-1beta with IC50 values of 0.22, 0.71, 16.4 muM and 10.8, 7.8, 6.4 muM, respectively.	Mosloflavone	57-69	interleukin 1 beta	Mus musculus	169-177
23768253-4	2013	These flavones also showed dose-dependent inhibition of TNF-alpha, IL-1beta and iNOS levels in the supernatant of mouse macrophage cell line J774A.	Flavones	6-14	interleukin 1 beta	Mus musculus	67-75
23983903-6	2013	for 7 days significantly suppressed the microglial expression of IL-1beta, TNF-alpha, IL-6, and 8-oxo-deoxyguanosine, a biomarker for oxidative damaged DNA, in the somatosensory cortex of mice subjected to hypoxia exposure (10% O2, 4 h).	Oxygen	228-230	interleukin 1 beta	Mus musculus	65-73
23355887-5	2013	Notably, LTP induction was also enhanced in hippocampal slices from control mice following interleukin-1beta (IL-1beta) perfusion, and both EAE and IL-1beta inhibited GABAergic spontaneous inhibitory postsynaptic currents (sIPSC) without affecting glutamatergic transmission and AMPA/NMDA ratio.	N-Methylaspartate	284-288	interleukin 1 beta	Mus musculus	148-156
23565150-4	2013	Furthermore, nano-TiO2 exposure resulted in marked increases of insulin-like growth factor-binding protein 2, epidermal growth factor, tumor necrosis factor-alpha, tissue plasminogen activator, interleukin-1beta, interleukin -6, Fas, and FasL expression, and significant decreases of insulin-like growth factor-1, luteinizing hormone receptor, inhibin alpha, and growth differentiation factor 9 expression in mouse ovary.	titanium dioxide	18-22	interleukin 1 beta	Mus musculus	194-211
23554921-5	2013	Phenserine treatment increased cortical synaptophysin levels in younger mice, while decreased interleukin-1beta and increased monocyte chemoattractant protein-1 and tumor necrosis factor-alpha levels were detected in the cortices of older mice.	phenserine	0-10	interleukin 1 beta	Mus musculus	94-111
23469077-3	2013	In the present study we found that administration of chemically modified tetracycline-3 (COL-3), inhibits lipopolysaccharide (LPS)-induced microglial and p38 MAPK activation, as well as the increase in TNF-alpha, but not IL-1beta expression, in the brains of BALB/c mice.	Tetracycline	73-85	interleukin 1 beta	Mus musculus	221-229
23827947-6	2013	SB203580 (p38 MAPK inhibitor) prevented IL-1beta-induced Cx43 upregulation.	SB 203580	0-8	interleukin 1 beta	Mus musculus	40-48
23827947-8	2013	Mefloquine (Panx1 blocker) reduced these IL-1beta responses.	Mefloquine	0-10	interleukin 1 beta	Mus musculus	41-49
22795564-12	2012	Myricetin inhibited the secretion of LPS-induced TNF-alpha and IL-1beta in the RAW264.7 cells.	myricetin	0-9	interleukin 1 beta	Mus musculus	63-71
23044226-13	2012	Oleocanthal also inhibits IL-1beta, TNF-alpha and GM-CSF protein synthesis from LPS-stimulated macrophages.	oleocanthal	0-11	interleukin 1 beta	Mus musculus	26-34
22975435-15	2012	Activated microglia secrete TNF-alpha and IL-1beta, which open connexin hemichannels in astrocytes.	hemichannels	72-84	interleukin 1 beta	Mus musculus	42-50
23174390-12	2012	IL-13 and IL-1beta were decreased 6 hours after alcohol exposure, and exposure to alcohol plus NAP plus SAL did not completely ameliorate the decrease.	Alcohols	48-55	interleukin 1 beta	Mus musculus	10-18
23010656-2	2012	Recent evidence supports both interleukin (IL) 1beta and short fragments of hyaluronan (HA) as contributors to the biological response to inhaled ozone.	Ozone	146-151	interleukin 1 beta	Mus musculus	30-52
22885069-4	2012	Knockdown of TMEM126A also blocked the down-regulation of IL-1beta and IL-6 expressions induced by CD137L in thioglycollate-elicited primary peritoneal macrophages.	Thioglycolates	109-123	interleukin 1 beta	Mus musculus	58-66
23027617-7	2012	BCAA supplementation also reduced both the amount of hepatic triglyceride accumulation and the expression of interleukin (IL)-6, IL-1beta, IL-18 and tumor necrosis factor-alpha mRNA in the liver.	Amino Acids, Branched-Chain	0-4	interleukin 1 beta	Mus musculus	129-137
23025713-9	2012	IL-1beta levels were 99.71 +- 85.22 and 230.76 +- 102.67 pg/ml in the UCS and PBS groups, respectively (p = 0.03).	pbs	78-81	interleukin 1 beta	Mus musculus	0-8
22712758-9	2012	Neutrophil migration and cytokine release (TNF-alpha, IL-1beta and IL-6) induced by zymosan and fluid leakage induced by acetic acid were also reduced in BS-treated animals.	Zymosan	84-91	interleukin 1 beta	Mus musculus	54-62
22782595-4	2012	In addition, heparin also inhibited the release of tumor necrosis factor (TNF)-alpha, interleukin-6 (IL-6) and IL-1beta in serum and decreased the expression of p-p38, nuclear factor kappaB (NF-kappaB) and p-c-SRC kinase in lungs of septic mice.	Heparin	13-20	interleukin 1 beta	Mus musculus	111-119
23053725-8	2012	Magnolol pretreatment significantly attenuated the severity of lung injury and inhibited the production of TNF-alpha and IL-1beta in mice with ALI.	magnolol	0-8	interleukin 1 beta	Mus musculus	121-129
23122727-8	2012	In addition, RO (100mg/kg) reduced the IL-1beta, but not TNF-alpha, local production induced by CFA.	rose-oxide	13-15	interleukin 1 beta	Mus musculus	39-47
23122727-13	2012	The results described here are the first report of pharmacological properties of RO and strongly suggest that RO possesses anti-inflammatory activity related to its ability to inhibit the IL-1beta production and the leukocyte migration.	rose-oxide	110-112	interleukin 1 beta	Mus musculus	188-196
21895782-5	2012	The highest non-cytotoxic concentrations of the ethanolic GSGME dose dependently reduced TNFalpha-induced NF-kappaB transactivation and decreased TNFalpha-induced mRNA levels of the NF-kappaB target genes IL-1beta, IL-8, MCP-1 and CXCL1 in Caco-2 intestinal cells (p &lt; 0.05).	gsgme	58-63	interleukin 1 beta	Mus musculus	205-213
23117929-6	2012	Inhibition of autophagy by 3-methylalanine in human and mouse adipose tissue explants led to a significant increase in IL-1beta, IL-6, and IL-8 mRNA expression and protein secretion.	3-toluidine	27-42	interleukin 1 beta	Mus musculus	119-127
23171450-9	2012	This ROS activate NLRP3, and NLRP3 leads to the production of caspase-1, which subsequently increases IL-1beta, thereby finally inducing inflammation.	Reactive Oxygen Species	5-8	interleukin 1 beta	Mus musculus	102-110
22865690-4	2012	TNF-alpha or IL-1beta stimulation produced a profound reduction (&gt;90%) of cyclic AMP within EOC2 microglia from 30 min that then recovered after IL-1beta but remained suppressed with TNF-alpha through 24 h. Cyclic AMP was also reduced in TNF-alpha-stimulated primary microglia, albeit to a lesser extent.	Cyclic AMP	77-87	interleukin 1 beta	Mus musculus	13-21
22865690-4	2012	TNF-alpha or IL-1beta stimulation produced a profound reduction (&gt;90%) of cyclic AMP within EOC2 microglia from 30 min that then recovered after IL-1beta but remained suppressed with TNF-alpha through 24 h. Cyclic AMP was also reduced in TNF-alpha-stimulated primary microglia, albeit to a lesser extent.	Cyclic AMP	210-220	interleukin 1 beta	Mus musculus	13-21
22865690-12	2012	These studies show that TNF-alpha and IL-1beta differentially affect cyclic AMP-PDE signaling in microglia.	Cyclic AMP	69-79	interleukin 1 beta	Mus musculus	38-46
22878137-6	2012	The results showed that geniposide markedly inhibited the LPS-induced TNF-alpha, IL-6 and IL-1beta production both in vitro and in vivo.	geniposide	24-34	interleukin 1 beta	Mus musculus	90-98
23036579-4	2012	Pretreatment with andrographolide sulfonate significantly decreased the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and transaminase activities in serum, attenuated liver and lung damage, and improved the survival of mice with experimental sepsis.	andrographolide sulfonate	18-43	interleukin 1 beta	Mus musculus	123-140
23036579-4	2012	Pretreatment with andrographolide sulfonate significantly decreased the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and transaminase activities in serum, attenuated liver and lung damage, and improved the survival of mice with experimental sepsis.	andrographolide sulfonate	18-43	interleukin 1 beta	Mus musculus	142-150
23036579-5	2012	Andrographolide sulfonate also remarkably reduced the expression levels of TNF-alpha, IL-1beta, IL-6 and inducible nitric oxide synthase in the injured liver from septic mice.	andrographolide sulfonate	0-25	interleukin 1 beta	Mus musculus	86-94
22342065-9	2012	IL-1beta triggered an increase of Kc release by primary cultured chondrocytes of 4.1-, 15.5- and 35.2-fold at 10, 50 and 100pg/mL of IL-1beta respectively (P&lt;0.05, n=4).	lysylcysteine	34-36	interleukin 1 beta	Mus musculus	0-8
22342065-9	2012	IL-1beta triggered an increase of Kc release by primary cultured chondrocytes of 4.1-, 15.5- and 35.2-fold at 10, 50 and 100pg/mL of IL-1beta respectively (P&lt;0.05, n=4).	lysylcysteine	34-36	interleukin 1 beta	Mus musculus	133-141
23232512-10	2012	Fasudil inhibited the expression of iNOS on microglia and p-NF-kappaB/p65 on astrocytes in spinal cords,  accompanied by the inhibition of inflammatory factors IL-1beta  and TNF-alpha.	fasudil	0-7	interleukin 1 beta	Mus musculus	160-168
23126293-7	2012	BBY suppressed the increases in both elastase activity and IL-1beta levels in the skin.	Bismark Brown	0-3	interleukin 1 beta	Mus musculus	59-67
22456813-3	2012	Injection of carrageenan into the pleural cavity induced an acute inflammatory response characterized by leukocyte migration, pleural exudation, and increased release of interleukin-1beta and tumor necrosis factor-alpha in pleural exudates.	Carrageenan	13-24	interleukin 1 beta	Mus musculus	170-219
22962328-6	2012	IL-1beta treatment stimulated secretion of prostaglandin F(2alpha) from RAW 264.7 cells.	Prostaglandins F	43-58	interleukin 1 beta	Mus musculus	0-8
23192054-3	2012	For the innate immune response, DAGE extract treatment enhanced the LPS-induced IL1-beta secretion by activated macrophages in vitro and long-term DAGE treatment (0.18 and 1.8 g/kg x 20 doses) elevated the phagocytic activity of macrophages, as well as natural killer cell activity in mice.	dage	32-36	interleukin 1 beta	Mus musculus	80-88
22782996-6	2012	Follow-up studies revealed that Tnf, Nfkb1, Il22, Il1b, Cxcl1, Cxcl2 and Cxcl5 mRNAs were highly expressed in epidermis of DBA/2 compared with C57BL/6 mice at 24h following treatment with TPA.	1,2,5,6-dibenzanthracene	123-126	interleukin 1 beta	Mus musculus	50-54
23097357-0	2012	Protein kinase a mediated anti-inflammatory effects exerted by adenosine treatment in mouse chondrocytes stimulated with IL-1beta.	Adenosine	63-72	interleukin 1 beta	Mus musculus	121-129
23097357-5	2012	In this study the effect of ADO treatment in normal murine chondrocytes stimulated with interleukin-1beta (IL-1beta) was investigated.	Adenosine	28-31	interleukin 1 beta	Mus musculus	88-105
23097357-5	2012	In this study the effect of ADO treatment in normal murine chondrocytes stimulated with interleukin-1beta (IL-1beta) was investigated.	Adenosine	28-31	interleukin 1 beta	Mus musculus	107-115
23097357-7	2012	IL-1beta stimulation significantly up-regulated HA levels, its fragmentation, cAMP, PKA, cytokine levels, and activated NF-kB.	Cyclic AMP	78-82	interleukin 1 beta	Mus musculus	0-8
22994384-4	2012	Fasudil inhibited TLR-4, p-NF-kB/p65, and inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and enhanced IL-10 production in spinal cords.	fasudil	0-7	interleukin 1 beta	Mus musculus	66-74
23085948-0	2012	Pre-treatment with IL-1beta enhances the efficacy of MSC transplantation in DSS-induced colitis.	Dextran Sulfate	76-79	interleukin 1 beta	Mus musculus	19-27
23085948-4	2012	Here, we focus on the therapeutic efficacy of IL-1beta-primed MSCs in the dextran sulfate sodium (DSS)-induced colitis model, in addition to the underlining mechanisms.	Dextran Sulfate	74-96	interleukin 1 beta	Mus musculus	46-54
23085948-4	2012	Here, we focus on the therapeutic efficacy of IL-1beta-primed MSCs in the dextran sulfate sodium (DSS)-induced colitis model, in addition to the underlining mechanisms.	Dextran Sulfate	98-101	interleukin 1 beta	Mus musculus	46-54
23085948-5	2012	We first found that IL-1beta-primed MSCs, without any observable phenotype change in vitro, significantly attenuated the development of DSS-induced murine colitis.	Dextran Sulfate	136-139	interleukin 1 beta	Mus musculus	20-28
23085948-8	2012	In summary, IL-1beta-primed MSCs have improved efficacy in treating DSS-induced colitis, which at least partly depends on their increased immunosuppressive capacities and enhanced migration ability.	Dextran Sulfate	68-71	interleukin 1 beta	Mus musculus	12-20
22831879-12	2012	Inhibition of iNOS activity in WT mice with L-Nil suppressed burn wound levels of IL-1beta, G-CSF, and MIP-1alpha, whereas IL-6, TNF-alpha, KC, MCP-1 and MIP-1beta were unaffected.	L-NIL	44-49	interleukin 1 beta	Mus musculus	82-90
22749439-11	2012	Sildenafil preserved myelin and axons ultrastructure and strongly reduced IFN-gamma, TNF-alpha, IL-1beta, IL-2 and COX-2 expression in comparison to the control and/or cuprizone groups.	Sildenafil Citrate	0-10	interleukin 1 beta	Mus musculus	96-104
22943972-6	2012	Due to Glu insults, the reduced mRNA levels of cytoplasmic glutathione peroxidase, copper/zinc and manganese superoxide dismutases, and Bcl-x(L) and the overexpressed mRNA levels of interleukin-1beta and tumor necrosis factor-alpha were significantly restored by post-treatment of capsaicin and/or resveratrol.	Capsaicin	281-290	interleukin 1 beta	Mus musculus	182-231
22901832-9	2012	Thalidomide treatment also significantly decreased plasma levels of nitric oxide and pancreatic proinflammatory cytokines [tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, IL-12, IL-17 and interferon (IFN)-gamma)] while increased anti-inflammatory cytokine IL-10.	Thalidomide	0-11	interleukin 1 beta	Mus musculus	158-180
22943972-6	2012	Due to Glu insults, the reduced mRNA levels of cytoplasmic glutathione peroxidase, copper/zinc and manganese superoxide dismutases, and Bcl-x(L) and the overexpressed mRNA levels of interleukin-1beta and tumor necrosis factor-alpha were significantly restored by post-treatment of capsaicin and/or resveratrol.	Resveratrol	298-309	interleukin 1 beta	Mus musculus	182-231
22939937-8	2012	RESULTS: BisGMA augmented the generation of IL-1beta, IL-6, nitric oxide and the expression of iNOS in a time- and dose-dependent manner (p&lt;0.05).	Bisphenol A-Glycidyl Methacrylate	9-15	interleukin 1 beta	Mus musculus	44-52
22537289-5	2012	As expected, melatonin inhibited TLR4-mediated tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta, IL-6, IL-8, and IL-10 in LPS-stimulated macrophages.	Melatonin	13-22	interleukin 1 beta	Mus musculus	88-110
22943972-6	2012	Due to Glu insults, the reduced mRNA levels of cytoplasmic glutathione peroxidase, copper/zinc and manganese superoxide dismutases, and Bcl-x(L) and the overexpressed mRNA levels of interleukin-1beta and tumor necrosis factor-alpha were significantly restored by post-treatment of capsaicin and/or resveratrol.	Glutamic Acid	7-10	interleukin 1 beta	Mus musculus	182-231
23107893-7	2012	MCP-1 mRNA level was significantly increased in injured femoral arteries, and administration of irbesartan with rosuvastatin decreased the mRNA levels of MCP-1, TNFalpha, and IL-1beta, and increased PPARgamma mRNA expression.	Irbesartan	96-106	interleukin 1 beta	Mus musculus	175-183
23107893-7	2012	MCP-1 mRNA level was significantly increased in injured femoral arteries, and administration of irbesartan with rosuvastatin decreased the mRNA levels of MCP-1, TNFalpha, and IL-1beta, and increased PPARgamma mRNA expression.	Rosuvastatin Calcium	112-124	interleukin 1 beta	Mus musculus	175-183
22869926-8	2012	In a system that evaluated cholesterol crystal-induced IL-1beta secretion via nucleotide-binding domain and leucine-rich repeat containing protein 3 inflammasome activation, quercetin also exhibited an inhibitory effect.	Cholesterol	27-38	interleukin 1 beta	Mus musculus	55-63
22869926-8	2012	In a system that evaluated cholesterol crystal-induced IL-1beta secretion via nucleotide-binding domain and leucine-rich repeat containing protein 3 inflammasome activation, quercetin also exhibited an inhibitory effect.	Quercetin	174-183	interleukin 1 beta	Mus musculus	55-63
22678775-3	2012	Through measurement with Griess reagent, dioscoreanone was found to reduce NO levels with an IC(50) value of 2.50 +- 0.64 microM, due to the significant suppression of LPS-induced iNOS mRNA expression, as well as IL-1beta and IL-6 levels at a concentration of 6 microM.	dioscoreanone	41-54	interleukin 1 beta	Mus musculus	213-221
22678775-7	2012	In conclusion, the mechanisms of dioscoreanone on the inhibition of NO production and mRNA expression of iNOS, IL-1beta, and IL-6 were due to both the inhibition of NF-kappaB activation and the activation of ERK1/2 proteins.	dioscoreanone	33-46	interleukin 1 beta	Mus musculus	111-119
23034169-6	2012	Selective depletion of MDSCs using gemcitabine results in a marked reduction in the severity of EAE (e.g., decreased clinical scores and myelin injury), which correlates with reduced Th17 cells and inflammatory cytokines (IL-17A and IL-1beta) in the lymphoid tissues and spinal cord.	gemcitabine	35-46	interleukin 1 beta	Mus musculus	233-241
22982349-11	2012	Furthermore, alpha-pinene pretreatment reduced the production of pancreatic tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 during cerulein-induced AP.	alpha-pinene	13-25	interleukin 1 beta	Mus musculus	111-133
22971898-14	2012	Nitidine chloride inhibits LPS-induced TNF alpha, IL-1beta and IL-6 production via the suppression of phosphorylation of MAPK and the translocation of p65.	nitidine	0-17	interleukin 1 beta	Mus musculus	50-58
22902631-6	2012	One of the quinazolinone derivatives showed significant anti-inflammatory activity in stimulated macrophage cells by inhibiting the expression of TNF-alpha, IL-1beta, IL-6, iNOS, COX-2, p-IkappaB and NF-kappaBp65.	Quinazolinones	11-24	interleukin 1 beta	Mus musculus	157-165
23022181-3	2012	alpha-Iso-cubebenol also significantly attenuates widespread immune cell apoptosis in a mouse CLP sepsis model, and inhibits the production of proinflammatory cytokines including interleukin-1beta (IL-1beta) and IL-6 in CLP mice and lipopolysaccharide-stimulated splenocytes.	alpha-iso-cubebenol	0-19	interleukin 1 beta	Mus musculus	179-196
23022181-3	2012	alpha-Iso-cubebenol also significantly attenuates widespread immune cell apoptosis in a mouse CLP sepsis model, and inhibits the production of proinflammatory cytokines including interleukin-1beta (IL-1beta) and IL-6 in CLP mice and lipopolysaccharide-stimulated splenocytes.	alpha-iso-cubebenol	0-19	interleukin 1 beta	Mus musculus	198-206
23036239-9	2012	RESULTS: Three percent NaCl attenuated the increase of brain water content, IL-1beta, TNFalpha, IgG, AQP4 mRNA and protein in brain tissues induced by LPS.	Sodium Chloride	23-27	interleukin 1 beta	Mus musculus	76-84
23036239-10	2012	Three percent NaCl inhibited the increase of AQP4 mRNA and protein in astrocytes induced by IL-1beta in vitro.	Sodium Chloride	14-18	interleukin 1 beta	Mus musculus	92-100
23000401-3	2012	Through a combination of in vitro and in vivo studies, we show that the proinflammatory cytokine IL-1beta induces divalent metal transporter 1 (DMT1) expression correlating with increased beta cell iron content and ROS production.	Iron	198-202	interleukin 1 beta	Mus musculus	97-105
23000401-3	2012	Through a combination of in vitro and in vivo studies, we show that the proinflammatory cytokine IL-1beta induces divalent metal transporter 1 (DMT1) expression correlating with increased beta cell iron content and ROS production.	Reactive Oxygen Species	215-218	interleukin 1 beta	Mus musculus	97-105
23036239-13	2012	In addition to its osmotic force, 3% NaCl exerted anti-edema effects possibly through down-regulating the expression of proinflammatory cytokines (IL-1beta and TNFalpha) and inhibiting the expression of AQP4 induced by proinflammatory cytokines.	Sodium Chloride	37-41	interleukin 1 beta	Mus musculus	147-155
22669487-4	2012	The results show that three types of SCFAs (acetate, propionate, and butyrate) reduced the production of proinflammatory factors, including TNF-alpha, IL-1beta, IL-6, and NO, and inhibited the vitality of iNOS.	Acetates	44-51	interleukin 1 beta	Mus musculus	151-159
23035099-4	2012	We found that a single intracerebroventricular injection of IL-1beta caused anxiety in mice, and abrogated the sensitivity of cannabinoid CB1 receptors (CB1Rs) controlling GABA synapses in the striatum.	gamma-Aminobutyric Acid	172-176	interleukin 1 beta	Mus musculus	60-68
23035099-6	2012	IL-1beta-mediated inhibition of CB1R function was secondary to altered cholesterol composition within membrane lipid rafts, and required intact function of the transient receptor potential vanilloid 1 (TRPV1) channel, another element of the endocannabinoid system.	Cholesterol	71-82	interleukin 1 beta	Mus musculus	0-8
23035099-8	2012	On the other hand, cholesterol enrichment of striatal slices mimicked the synaptic effects of IL-1beta on CB1Rs only in control mice, while the same treatment was ineffective in slices prepared from TRPV1-/- mice.	Cholesterol	19-30	interleukin 1 beta	Mus musculus	94-102
23035103-10	2012	These findings indicate that amygdala-based anterograde amnesia after hypoxia/reoxygenation is sustained by IL-1beta generated through adenosine-dependent activation of caspase 1 after reoxygenation.	Adenosine	135-144	interleukin 1 beta	Mus musculus	108-116
23213315-4	2012	In this study we investigated the role of the PA as inhibitor of caspase-1, which converts prointerleukin-1beta (proIL-1beta) to active IL-1beta and is activated by inflammasome involved in the inflammatory process.	Protactinium	46-48	interleukin 1 beta	Mus musculus	116-124
23213315-5	2012	We tested the effect of PA on the production of pro-inflammatory cytokines, IL-1beta in murine macrophage cell line, RAW264.7.	Protactinium	24-26	interleukin 1 beta	Mus musculus	76-84
23213315-6	2012	PA inhibited lipopolysaccharide (LPS)-induced IL-1beta production by macrophages at a dose dependent manner.	Protactinium	0-2	interleukin 1 beta	Mus musculus	46-54
23013134-13	2012	In addition, (99)Tc-MDP inhibited the expression of the inflammatory factors interleukin (IL)-6, tumour necrosis factor-alpha and IL-1beta.	technetium Tc 99m diphosphonate	17-23	interleukin 1 beta	Mus musculus	130-138
22588329-6	2012	The results showed that the production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-10 was considerably increased by LPS, but the change could be markedly attenuated by pretreatment with propofol.	Propofol	216-224	interleukin 1 beta	Mus musculus	83-105
22669487-4	2012	The results show that three types of SCFAs (acetate, propionate, and butyrate) reduced the production of proinflammatory factors, including TNF-alpha, IL-1beta, IL-6, and NO, and inhibited the vitality of iNOS.	Propionates	53-63	interleukin 1 beta	Mus musculus	151-159
22644339-7	2012	The results showed that stevioside dose-dependently inhibited the expression of tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta in LPS-stimulated RAW264.7 cells.	stevioside	24-34	interleukin 1 beta	Mus musculus	128-145
22699806-9	2012	(PhSe)(2) partially protected against the increase in TNF-alpha, IL-1beta, IL-6 and INF-gamma levels induced by carrageenan.	Carrageenan	112-123	interleukin 1 beta	Mus musculus	65-73
22669487-4	2012	The results show that three types of SCFAs (acetate, propionate, and butyrate) reduced the production of proinflammatory factors, including TNF-alpha, IL-1beta, IL-6, and NO, and inhibited the vitality of iNOS.	Butyrates	69-77	interleukin 1 beta	Mus musculus	151-159
22641092-9	2012	Nilotinib lowered intrahepatic expression of IL-1beta, IL-6, MCP-1, and MIP-2 and systemic levels of IL-6, MCP-1, and TNF.	nilotinib	0-9	interleukin 1 beta	Mus musculus	45-53
22945633-4	2012	Using IL-1Ra-treated mice as well as 3 mouse models deficient in regulators of IL-1beta activation (Casp-1 and ASC) or signaling (IL-1R1), we found that IL-1beta signaling is required for the development of alcohol-induced liver steatosis, inflammation, and injury.	Alcohols	207-214	interleukin 1 beta	Mus musculus	153-161
22849695-9	2012	Orally administered ginsenoside Re significantly inhibited the expression of IL-1beta and TNF-alpha on LPS-induced systemic inflammation and TNBS-induced colitis in mice.	Ginsenosides	20-31	interleukin 1 beta	Mus musculus	77-85
22817402-5	2012	Intraperitonial injection of IL-1beta at varying doses (0-10 mug) caused a concentration-dependent increase in mouse intestinal permeability to the paracellular marker dextran (10 KD), and the maximal increase in dextran flux occurred at IL-1beta dose of 5 mug.	Dextrans	168-175	interleukin 1 beta	Mus musculus	29-37
23031399-6	2012	Incision after saline or escalating morphine treatment upregulated skin IL-1beta, IL-6, G-CSF and MIP-1alpha levels in ppt-A(-/-) and wt mice similarly.	Sodium Chloride	15-21	interleukin 1 beta	Mus musculus	72-80
23031399-6	2012	Incision after saline or escalating morphine treatment upregulated skin IL-1beta, IL-6, G-CSF and MIP-1alpha levels in ppt-A(-/-) and wt mice similarly.	Morphine	36-44	interleukin 1 beta	Mus musculus	72-80
22750064-13	2012	Diacerein (5.0-25.0 mg/kg) also produced dose related inhibition of interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) induced nociception.	diacerein	0-9	interleukin 1 beta	Mus musculus	68-85
22750064-13	2012	Diacerein (5.0-25.0 mg/kg) also produced dose related inhibition of interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) induced nociception.	diacerein	0-9	interleukin 1 beta	Mus musculus	87-95
22849695-5	2012	Ginsenoside Re inhibited IKK-beta phosphorylation and NF-kappaB activation, as well as the expression of proinflammatory cytokines, TNF-alpha and IL-1beta, in LPS-stimulated peritoneal macrophages, but it did not inhibit them in TNF-alpha- or PG-stimulated peritoneal macrophages.	Ginsenosides	0-11	interleukin 1 beta	Mus musculus	146-154
22817402-5	2012	Intraperitonial injection of IL-1beta at varying doses (0-10 mug) caused a concentration-dependent increase in mouse intestinal permeability to the paracellular marker dextran (10 KD), and the maximal increase in dextran flux occurred at IL-1beta dose of 5 mug.	Dextrans	213-220	interleukin 1 beta	Mus musculus	29-37
22817402-7	2012	MLCK inhibitor ML-7 (2 mg/kg body weight) also inhibited the IL-1beta-induced increase in small intestinal permeability.	ML 7	15-19	interleukin 1 beta	Mus musculus	61-69
22940134-3	2012	alpha-Iso-cubebene also significantly attenuated lung inflammation and widespread immune cell apoptosis in a mouse CLP sepsis model, and inhibited the production of proinflammatory cytokines including tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 in CLP mice and lipopolysaccharide-stimulated splenocytes.	alpha-iso-cubebene	0-18	interleukin 1 beta	Mus musculus	230-252
22790598-7	2012	Elevated morphological damage, ileal IL-1beta and IL-6 levels, and bacterial translocation were seen in mice exposed to ethanol and burn injury relative to either insult alone.	Ethanol	120-127	interleukin 1 beta	Mus musculus	37-45
22904305-5	2012	In a second model of IL-1beta-driven inflammation, NLRP3 activation by monosodium urate crystals similarly increased IL-6.	Uric Acid	71-87	interleukin 1 beta	Mus musculus	21-29
22820172-5	2012	KEY FINDING: Concurrent use of cilostazol and MTX effectively suppressed proliferation and cell viability associated with enhanced apoptosis of synovial fibroblasts and significantly suppressed cytokine production, including TNF-alpha, IL-1beta, IL-6, and MCP-1 in an additive manner.	Cilostazol	31-41	interleukin 1 beta	Mus musculus	236-244
22820172-5	2012	KEY FINDING: Concurrent use of cilostazol and MTX effectively suppressed proliferation and cell viability associated with enhanced apoptosis of synovial fibroblasts and significantly suppressed cytokine production, including TNF-alpha, IL-1beta, IL-6, and MCP-1 in an additive manner.	Methotrexate	46-49	interleukin 1 beta	Mus musculus	236-244
22820108-2	2012	Methamphetamine-induced hyperthermia involves a variety of cellular mechanisms, including increases in hypothalamic interleukin-1 beta (IL-1beta) expression.	Methamphetamine	0-15	interleukin 1 beta	Mus musculus	116-134
22820108-2	2012	Methamphetamine-induced hyperthermia involves a variety of cellular mechanisms, including increases in hypothalamic interleukin-1 beta (IL-1beta) expression.	Methamphetamine	0-15	interleukin 1 beta	Mus musculus	136-144
22820108-4	2012	The purpose of the current study was to determine if the attenuation of methamphetamine-induced hyperthermia by the sigma receptor antagonists, AZ66 and SN79, is associated with a concomitant attenuation of IL-1beta mRNA expression, particularly in the hypothalamus.	Methamphetamine	72-87	interleukin 1 beta	Mus musculus	207-215
22820108-5	2012	Methamphetamine produced dose- and time-dependent increases in core body temperature and IL-1beta mRNA expression in the hypothalamus, striatum, and cortex in male, Swiss Webster mice.	Methamphetamine	0-15	interleukin 1 beta	Mus musculus	89-97
22820108-6	2012	Pretreatment with the sigma receptor antagonists, AZ66 and SN79, significantly attenuated methamphetamine-induced hyperthermia, but further potentiated IL-1beta mRNA in the mouse hypothalamus when compared to animals treated with methamphetamine alone.	az66	50-54	interleukin 1 beta	Mus musculus	152-160
22820108-6	2012	Pretreatment with the sigma receptor antagonists, AZ66 and SN79, significantly attenuated methamphetamine-induced hyperthermia, but further potentiated IL-1beta mRNA in the mouse hypothalamus when compared to animals treated with methamphetamine alone.	sn79	59-63	interleukin 1 beta	Mus musculus	152-160
22917537-4	2012	Resveratrol inhibited LPS-induced production of nitric oxide (NO); the cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin 1-beta (IL-1beta), and IL-6; and the chemokine monocyte chemotactic protein-1 (MCP-1), which play critical roles in innate immunity, by astrocytes.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	122-140
22789837-11	2012	Moreover, phloroglucinol inhibited the IL-1beta-induced PGE(2) production in pulp fibroblasts.	Phloroglucinol	10-24	interleukin 1 beta	Mus musculus	39-47
22789837-11	2012	Moreover, phloroglucinol inhibited the IL-1beta-induced PGE(2) production in pulp fibroblasts.	Dinoprostone	56-62	interleukin 1 beta	Mus musculus	39-47
22687552-3	2012	PCP increased the production of nitric oxide (NO) and the gene expression of IL-1beta, IL-6, and TNF-alpha in RAW 264.7 cells.	pcp	0-3	interleukin 1 beta	Mus musculus	77-85
22939729-6	2012	RESULTS: Pravastatin reduced interleukin (IL)-1beta and IL-6 mRNA expression in the uterus and cervix, respectively, and serum IL-1beta and granulocyte-macrophage colony-stimulating factor (GM-CSF) concentrations.	Pravastatin	9-20	interleukin 1 beta	Mus musculus	29-51
22939729-7	2012	Simvastatin reduced IL-1beta and IL-6 mRNA expressions in the uterus, IL-6 and tumor necrosis factor alpha (TNF-alpha) in the cervix, and IL-1beta, IL-2, IL-12p70, IL-13, TNF-alpha, GM-CSF, and interferon-gamma concentrations in the serum and IL-6 in AF.	Simvastatin	0-11	interleukin 1 beta	Mus musculus	20-28
22939729-7	2012	Simvastatin reduced IL-1beta and IL-6 mRNA expressions in the uterus, IL-6 and tumor necrosis factor alpha (TNF-alpha) in the cervix, and IL-1beta, IL-2, IL-12p70, IL-13, TNF-alpha, GM-CSF, and interferon-gamma concentrations in the serum and IL-6 in AF.	Simvastatin	0-11	interleukin 1 beta	Mus musculus	138-146
22691576-6	2012	In line with prior studies, we demonstrate that LEV modulates both the relative gene expression and secretion of IL-1beta and TGF-1beta.	Levetiracetam	48-51	interleukin 1 beta	Mus musculus	113-121
22169929-10	2012	Our results reveal that ceramide causes inflammasome activation, induction of caspase-1, IL-1beta cleavage, and release of proinflammatory cytokines.	Ceramides	24-32	interleukin 1 beta	Mus musculus	89-97
22713932-3	2012	We found that in vitro pretreatment with pinocembrin remarkably regulated the production of TNF-alpha, IL-1beta, IL-6 and IL-10 via inhibiting the phosphorylation of IkappaBalpha, ERK1/2, JNK and p38MAPK.	pinocembrin	41-52	interleukin 1 beta	Mus musculus	103-111
22735758-8	2012	Oral administration of LH inhibited lipopolysaccharide (LPS)-induced TNF-alpha and IL-1beta expressions in beta-estradiol-immunosuppressed mice but reversed the expression of anti-inflammatory cytokine IL-10 in comparison to levels observed in the normal control group.	Luteinizing Hormone	23-25	interleukin 1 beta	Mus musculus	83-91
22819845-7	2012	In vitro experiments showed that calcium phosphate crystals induced caspase-1 activation and secretion of IL-1beta and IL-1alpha in macrophages.	calcium phosphate	33-50	interleukin 1 beta	Mus musculus	106-114
22542583-3	2012	The results obtained showed that paeonol significantly suppressed LPS induced release of pro-inflammatory products such as nitric oxide (NO), prostaglandin E2 (PGE(2)), and cytokines; tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	paeonol	33-40	interleukin 1 beta	Mus musculus	225-242
22542583-3	2012	The results obtained showed that paeonol significantly suppressed LPS induced release of pro-inflammatory products such as nitric oxide (NO), prostaglandin E2 (PGE(2)), and cytokines; tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	paeonol	33-40	interleukin 1 beta	Mus musculus	244-252
22895716-9	2012	Furthermore, CatB deficiency or CA-074Me treatment significantly inhibited the maturation and secretion of IL-1beta and IL-18 by cultured microglia following treatment with the neuroactive glycoprotein chromogranin A (CGA), but not with ATP.	CA 074 methyl ester	32-40	interleukin 1 beta	Mus musculus	107-115
22683568-7	2012	Finally, although simvastatin (20 mg/kg) conferred significant protection in murine ALI as evidenced by decreased bronchoalveolar lavage fluid cell counts, protein, inflammatory cytokines (IL-6, IL-1beta, MCP-1, RANTES), decreased Evans blue dye albumin extravasation in lung tissue, and changes on lung histology, these effects were reversed by the integrin-beta4-blocking antibody (IV, 1 mg/kg, 2 h before LPS).	Simvastatin	18-29	interleukin 1 beta	Mus musculus	195-203
22909126-7	2012	However, the clinical symptoms of the DSS-treated APNKO mice were worse than WT mice treated with DSS and had increased susceptibility to intestinal inflammation due to increased local STAT3 activation, higher IL-6, TNF-alpha, IL-1beta and IL-10 levels, and as a result had increased intestinal epithelial cell proliferation (p &lt; 0.05).	dss	38-41	interleukin 1 beta	Mus musculus	227-235
22820183-7	2012	We then examined the effect of recombinant TNF-alpha and IL-1beta on the VSMC-derived osteogenic signals.	vsmc	73-77	interleukin 1 beta	Mus musculus	57-65
22820183-10	2012	On the other hand, VSMCs significantly enhanced IL-1beta expression in macrophages, which might in turn accelerate the VSMC-mediated osteogenic signals.	vsmcs	19-24	interleukin 1 beta	Mus musculus	48-56
22820183-10	2012	On the other hand, VSMCs significantly enhanced IL-1beta expression in macrophages, which might in turn accelerate the VSMC-mediated osteogenic signals.	vsmc	19-23	interleukin 1 beta	Mus musculus	48-56
22895716-10	2012	Moreover, the IL-1beta expression in spinal microglia and the induction of tactile allodynia following the intrathecal administration of CGA depended on CatB, whereas those induced by the intrathecal administration of ATP or lysophosphatidic acid were CatB independent.	Adenosine Triphosphate	218-221	interleukin 1 beta	Mus musculus	14-22
22428664-5	2012	KEY RESULTS: Morphine enhanced release of the proinflammatory cytokines, IL-1beta, TNF-alpha, IL-6, and of NO via micro-opioid receptor in activated microglial cells.	Morphine	13-21	interleukin 1 beta	Mus musculus	73-81
22882971-5	2012	RESULTS: In the present study, we have shown that 6 h exposure to non-crystalline SiO2 particles in nano- (SiNPs, 5-20 nm, 50 nm) and submicro-sizes induced strong IL-1beta responses in LPS-primed mouse macrophages (RAW264.7) and primary rat lung macrophages.	Silicon Dioxide	82-86	interleukin 1 beta	Mus musculus	164-172
22537595-9	2012	Western blot analyses revealed that CUS induced a significant increase of GDNF and a significant decrease in IL-1beta.	cus	36-39	interleukin 1 beta	Mus musculus	109-117
22523418-8	2012	Furthermore, MAB seems to present an antiinflammatory effect evidenced by the interference in both the neutrophil migration and in the increase of interleukin-1beta levels after carrageenan injection.	Carrageenan	178-189	interleukin 1 beta	Mus musculus	147-164
22622792-8	2012	Indomethacin decreased the tissue levels of IL-1beta at 3 days after fracture but did not affect the recruitment of macrophages or neutrophils to injured limbs.	Indomethacin	0-12	interleukin 1 beta	Mus musculus	44-52
22776035-4	2012	In addition, salidroside also inhibited the production of several inflammatory cytokines, including tumor necrosis factor-alpha, interleukin-6 (IL-6) and IL-1beta, and the NF-kappaB DNA-binding activation after LPS challenge.	rhodioloside	13-24	interleukin 1 beta	Mus musculus	154-162
22369073-7	2012	Donepezil reduced expression of IL (interleukin)-1beta and VEGF (vascular endothelial growth factor) in the ischaemic hindlimb.	Donepezil	0-9	interleukin 1 beta	Mus musculus	32-54
22369073-8	2012	Intramuscular injections of IL-1beta to the ischaemic hindlimb reversed the donepezil-induced VEGF down-regulation and the anti-angiogenic effect.	Donepezil	76-85	interleukin 1 beta	Mus musculus	28-36
22369073-9	2012	Hypoxia induced IL-1beta expression in C2C12 myoblast cells, which was inhibited by pre-incubation with ACh (acetylcholine) or LY294002, a PI3K (phosphoinositide 3-kinase) inhibitor.	Acetylcholine	104-107	interleukin 1 beta	Mus musculus	16-24
22369073-9	2012	Hypoxia induced IL-1beta expression in C2C12 myoblast cells, which was inhibited by pre-incubation with ACh (acetylcholine) or LY294002, a PI3K (phosphoinositide 3-kinase) inhibitor.	Acetylcholine	109-122	interleukin 1 beta	Mus musculus	16-24
22369073-9	2012	Hypoxia induced IL-1beta expression in C2C12 myoblast cells, which was inhibited by pre-incubation with ACh (acetylcholine) or LY294002, a PI3K (phosphoinositide 3-kinase) inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	interleukin 1 beta	Mus musculus	16-24
22427154-6	2012	Bzb treatment significantly reduced the expression of TNF-alpha, IL-1beta, IL-6, MCP-1, MIP-1alpha, iNOS, and COX-2 and induced the expression of IL-10 in a time-dependent manner.	Bortezomib	0-3	interleukin 1 beta	Mus musculus	65-73
22621868-4	2012	Tb attenuated the production of TNFalpha and IL-1beta by peritoneal macrophages and their expression in adipose tissue.	tributyrin	0-2	interleukin 1 beta	Mus musculus	45-53
22726258-9	2012	RESULTS: Oral GlcCer administration significantly suppressed mRNA expression of the pro-inflammatory cytokines IL-1beta and IL-6.	Glucosylceramides	14-20	interleukin 1 beta	Mus musculus	111-119
22977683-8	2012	After 30 days of radiation, interleukin (IL)-1beta and IL-6 secretion decreased significantly in the radiation-quercetin groups.	Quercetin	111-120	interleukin 1 beta	Mus musculus	28-50
22522029-6	2012	Alternatively, beta-TCP particles treatment for 24 h significantly increased the osteocytic marker SOST/sclerostin mRNA expression and the release of inflammatory cytokines including TNF-alpha and IL-1beta into the culture media, but decreased the mRNA expression of another osteocytic marker dentin matrix protein-1 (DMP-1).	beta-tricalcium phosphate	15-23	interleukin 1 beta	Mus musculus	197-205
22575169-8	2012	In wild type mice hepatic expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-12, products of classically activated macrophages, increased after acetaminophen administration.	Acetaminophen	173-186	interleukin 1 beta	Mus musculus	75-97
22575169-10	2012	Loss of STK blunted the effects of acetaminophen on expression of TNFalpha, IL-1beta, IL-12, MCP-1 and CCR2, while expression of IL-10 increased.	Acetaminophen	35-48	interleukin 1 beta	Mus musculus	76-84
22231145-9	2012	RESULTS: IL-1beta-induced cPLA2 expression was mediated through NOX activation/ROS production, which was attenuated by N-acetylcysteine (NAC; a scavenger of ROS), the inhibitors of NOX (diphenyleneiodonium chloride and apocynin), MEK-1/2 (U0126), and JNK-1/2 (SP600125), transfection with the respective siRNAs, and the overexpression of HO-1 in RASFs.	pyrazolanthrone	260-268	interleukin 1 beta	Mus musculus	9-17
22772811-2	2012	In the mouse model of LPS-induced acute lung injury, intraperitoneal preconditioning with p-cymene resulted in a significant reduction of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6), lung water gain, inflammatory cell infiltration, lung tissue myeloperoxidase activity.	4-cymene	90-98	interleukin 1 beta	Mus musculus	177-185
22231145-3	2012	The aim of this study was to examine the mechanisms underlying interleukin-1beta (IL-1beta)-induced cytosolic phospholipase A2 (cPLA2) expression through ROS generation as modulated by HO-1 in RA synovial fibroblasts (RASFs).	Reactive Oxygen Species	154-157	interleukin 1 beta	Mus musculus	63-80
22231145-3	2012	The aim of this study was to examine the mechanisms underlying interleukin-1beta (IL-1beta)-induced cytosolic phospholipase A2 (cPLA2) expression through ROS generation as modulated by HO-1 in RA synovial fibroblasts (RASFs).	Reactive Oxygen Species	154-157	interleukin 1 beta	Mus musculus	82-90
22645149-8	2012	Epoxyazadiradione prevented the release of proinflammatory cytokines such as IL-1alpha, IL-1beta, IL-6, and TNF-alpha when LPS and PyMIF were co-administered to BALB/c mice.	epoxyazadiradione	0-17	interleukin 1 beta	Mus musculus	88-96
22698256-10	2012	Consequently, it appears likely that the beneficial nutritional effects of resveratrol and pterostilbene are due at least in part, to their ability to inhibit NF-kappaB activation by the proteasome, thereby suppressing activation of pro-inflammatory cytokines and iNOS genes, resulting in decreased secretion of TNF-alpha, IL-1beta, IL-6, and NO levels, in response to inflammatory stimuli.	Resveratrol	75-86	interleukin 1 beta	Mus musculus	323-331
22698256-10	2012	Consequently, it appears likely that the beneficial nutritional effects of resveratrol and pterostilbene are due at least in part, to their ability to inhibit NF-kappaB activation by the proteasome, thereby suppressing activation of pro-inflammatory cytokines and iNOS genes, resulting in decreased secretion of TNF-alpha, IL-1beta, IL-6, and NO levels, in response to inflammatory stimuli.	pterostilbene	91-104	interleukin 1 beta	Mus musculus	323-331
22753701-6	2012	After grafting of Hep-55.1C cells into mouse liver, the oral administration of silibinin at 700 mg/kg body weight for four weeks caused a significant reduction of tumor growth, associated with the down-regulation of inflammatory components [matrix metalloproteinase -7 and -9, (MMP-7, MMP-9), Interleukin-1 beta (IL1beta)], the up-regulation of apoptotic mediators (TRAIL, DR5), and caspase-3 activation.	Silybin	79-88	interleukin 1 beta	Mus musculus	293-311
22753701-6	2012	After grafting of Hep-55.1C cells into mouse liver, the oral administration of silibinin at 700 mg/kg body weight for four weeks caused a significant reduction of tumor growth, associated with the down-regulation of inflammatory components [matrix metalloproteinase -7 and -9, (MMP-7, MMP-9), Interleukin-1 beta (IL1beta)], the up-regulation of apoptotic mediators (TRAIL, DR5), and caspase-3 activation.	Silybin	79-88	interleukin 1 beta	Mus musculus	313-320
22864752-5	2012	Our results demonstrate that DBC (MW 3,772) significantly inhibits overproduction of NO and PGE(2) as well as pro-inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-1beta, in LPS-stimulated RAW 264.7 macrophages.	di-O-butyrylchitin	29-32	interleukin 1 beta	Mus musculus	178-195
22541537-5	2012	In addition to the increased expression of Shh, MAA-treated wounds had increased expression of osteopontin (OPN), IL-1beta and TNF-alpha, (at day 7) similar to the previously reported MAA response of macrophage-like and endothelial cells in vitro.	monomethylarsonic acid	48-51	interleukin 1 beta	Mus musculus	114-122
22231145-4	2012	METHODS: IL-1beta-induced ROS generation was determined by flow cytometry.	Reactive Oxygen Species	26-29	interleukin 1 beta	Mus musculus	9-17
22231145-5	2012	The involvement of MAPKs and NADPH oxidase (NOX)/ROS in IL-1beta-induced cPLA2 expression was investigated using pharmacologic inhibitors and transfection with small interfering RNAs (siRNAs) and was analyzed by Western blotting and promoter assay.	Reactive Oxygen Species	49-52	interleukin 1 beta	Mus musculus	56-64
22231145-9	2012	RESULTS: IL-1beta-induced cPLA2 expression was mediated through NOX activation/ROS production, which was attenuated by N-acetylcysteine (NAC; a scavenger of ROS), the inhibitors of NOX (diphenyleneiodonium chloride and apocynin), MEK-1/2 (U0126), and JNK-1/2 (SP600125), transfection with the respective siRNAs, and the overexpression of HO-1 in RASFs.	Reactive Oxygen Species	79-82	interleukin 1 beta	Mus musculus	9-17
22231145-9	2012	RESULTS: IL-1beta-induced cPLA2 expression was mediated through NOX activation/ROS production, which was attenuated by N-acetylcysteine (NAC; a scavenger of ROS), the inhibitors of NOX (diphenyleneiodonium chloride and apocynin), MEK-1/2 (U0126), and JNK-1/2 (SP600125), transfection with the respective siRNAs, and the overexpression of HO-1 in RASFs.	Acetylcysteine	119-135	interleukin 1 beta	Mus musculus	9-17
22231145-9	2012	RESULTS: IL-1beta-induced cPLA2 expression was mediated through NOX activation/ROS production, which was attenuated by N-acetylcysteine (NAC; a scavenger of ROS), the inhibitors of NOX (diphenyleneiodonium chloride and apocynin), MEK-1/2 (U0126), and JNK-1/2 (SP600125), transfection with the respective siRNAs, and the overexpression of HO-1 in RASFs.	Acetylcysteine	137-140	interleukin 1 beta	Mus musculus	9-17
22231145-9	2012	RESULTS: IL-1beta-induced cPLA2 expression was mediated through NOX activation/ROS production, which was attenuated by N-acetylcysteine (NAC; a scavenger of ROS), the inhibitors of NOX (diphenyleneiodonium chloride and apocynin), MEK-1/2 (U0126), and JNK-1/2 (SP600125), transfection with the respective siRNAs, and the overexpression of HO-1 in RASFs.	Reactive Oxygen Species	157-160	interleukin 1 beta	Mus musculus	9-17
22231145-10	2012	IL-1beta-induced cPLA2 expression was mediated through recruitment of activator protein 1 (AP-1) to the cPLA2 promoter region, which was attenuated by NAC and overexpression of HO-1.	Acetylcysteine	151-154	interleukin 1 beta	Mus musculus	0-8
22231145-9	2012	RESULTS: IL-1beta-induced cPLA2 expression was mediated through NOX activation/ROS production, which was attenuated by N-acetylcysteine (NAC; a scavenger of ROS), the inhibitors of NOX (diphenyleneiodonium chloride and apocynin), MEK-1/2 (U0126), and JNK-1/2 (SP600125), transfection with the respective siRNAs, and the overexpression of HO-1 in RASFs.	diphenyleneiodonium	186-214	interleukin 1 beta	Mus musculus	9-17
22231145-9	2012	RESULTS: IL-1beta-induced cPLA2 expression was mediated through NOX activation/ROS production, which was attenuated by N-acetylcysteine (NAC; a scavenger of ROS), the inhibitors of NOX (diphenyleneiodonium chloride and apocynin), MEK-1/2 (U0126), and JNK-1/2 (SP600125), transfection with the respective siRNAs, and the overexpression of HO-1 in RASFs.	acetovanillone	219-227	interleukin 1 beta	Mus musculus	9-17
22231145-12	2012	CONCLUSION: In RASFs, IL-1beta induced cPLA2 expression via activation of p42/p44 MAPK and JNK-1/2, leading to p47phox phosphorylation, ROS production, and AP-1 activation.	Reactive Oxygen Species	136-139	interleukin 1 beta	Mus musculus	22-30
22231145-9	2012	RESULTS: IL-1beta-induced cPLA2 expression was mediated through NOX activation/ROS production, which was attenuated by N-acetylcysteine (NAC; a scavenger of ROS), the inhibitors of NOX (diphenyleneiodonium chloride and apocynin), MEK-1/2 (U0126), and JNK-1/2 (SP600125), transfection with the respective siRNAs, and the overexpression of HO-1 in RASFs.	U 0126	239-244	interleukin 1 beta	Mus musculus	9-17
22579116-6	2012	(2) Primary cultured mouse mammary epithelial cells were treated with 0, 5, 15 or 45 mmol/L taurine for 3 h, followed by 10 mug/mL LPS for 24 h. Taurine significantly attenuated the LPS-induced increase in NAGase activity, NO concentrations and the level of TNF-alpha, IL-1beta, IL-6 and LF.	Taurine	145-152	interleukin 1 beta	Mus musculus	269-277
22595195-8	2012	Administration of the spinasterol-Glc significantly decreased the plasma levels of these inflammatory mediators including TNF-alpha, IL-6 and IL-1beta in LPS-injected mice and improved survival of septic mice with lethal endotoxemia.	spinasterol	22-33	interleukin 1 beta	Mus musculus	142-150
22490780-2	2012	PGE2 is a well-established endogenous pyrogen activated by proinflammatory cytokine interleukin (IL)-1beta.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	84-106
22490780-3	2012	P2X7 receptors (P2X7Rs) expressed by inflammatory cells are stimulated by the danger signal extracellular ATP to activate the inflammasome and release IL-1beta.	Adenosine Triphosphate	106-109	interleukin 1 beta	Mus musculus	151-159
22490780-4	2012	Here we show that P2X7R activation is required for the release of PGE2 and other autacoids independent of inflammasome activation, with an ATP EC(50) for PGE2 and IL-1beta release of 1.58 and 1.23 mM, respectively.	Dinoprostone	66-70	interleukin 1 beta	Mus musculus	163-171
22490780-4	2012	Here we show that P2X7R activation is required for the release of PGE2 and other autacoids independent of inflammasome activation, with an ATP EC(50) for PGE2 and IL-1beta release of 1.58 and 1.23 mM, respectively.	atp ec	139-145	interleukin 1 beta	Mus musculus	163-171
22564506-11	2012	The effects of santamarin on LPS-induced NO, PGE(2), TNF-alpha, and IL-1beta production were partially reversed by the HO-1 inhibitor, tin protoporphyrin (SnPP).	tin protoporphyrin IX	135-153	interleukin 1 beta	Mus musculus	68-76
22564506-6	2012	Similarly, santamarin reduced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production.	santamarine	11-21	interleukin 1 beta	Mus musculus	74-91
22595195-8	2012	Administration of the spinasterol-Glc significantly decreased the plasma levels of these inflammatory mediators including TNF-alpha, IL-6 and IL-1beta in LPS-injected mice and improved survival of septic mice with lethal endotoxemia.	Glucose	34-37	interleukin 1 beta	Mus musculus	142-150
22564506-6	2012	Similarly, santamarin reduced tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production.	santamarine	11-21	interleukin 1 beta	Mus musculus	93-101
22564506-11	2012	The effects of santamarin on LPS-induced NO, PGE(2), TNF-alpha, and IL-1beta production were partially reversed by the HO-1 inhibitor, tin protoporphyrin (SnPP).	santamarine	15-25	interleukin 1 beta	Mus musculus	68-76
22564506-11	2012	The effects of santamarin on LPS-induced NO, PGE(2), TNF-alpha, and IL-1beta production were partially reversed by the HO-1 inhibitor, tin protoporphyrin (SnPP).	S-Nitroso-N-propionyl-D,L-penicillamine	155-159	interleukin 1 beta	Mus musculus	68-76
22696397-3	2012	Cardamonin (30 and 100 mg/kg) significantly elevated the survival rate of septic mice, alleviated ALI and lung microvascular leak, and lowered the serum levels of proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6.	cardamonin	0-10	interleukin 1 beta	Mus musculus	200-208
22595195-4	2012	Our results showed that spinasterol-Glc inhibited the production of NO and proinflammatory cytokines such as TNF-alpha, IL-6 and IL-1beta in dose-dependent manners in LPS-treated RAW264.7 cells.	spinasterol	24-35	interleukin 1 beta	Mus musculus	129-137
22595195-4	2012	Our results showed that spinasterol-Glc inhibited the production of NO and proinflammatory cytokines such as TNF-alpha, IL-6 and IL-1beta in dose-dependent manners in LPS-treated RAW264.7 cells.	Glucose	36-39	interleukin 1 beta	Mus musculus	129-137
22552813-6	2012	Naringenin also             attenuated the production of pro-inflammatory cytokines and chemokines, including             interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant             protein-1 (MCP-1) by suppressing expression of mRNAs for these proteins.	naringenin	0-10	interleukin 1 beta	Mus musculus	122-139
22552813-6	2012	Naringenin also             attenuated the production of pro-inflammatory cytokines and chemokines, including             interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant             protein-1 (MCP-1) by suppressing expression of mRNAs for these proteins.	naringenin	0-10	interleukin 1 beta	Mus musculus	141-149
21190757-0	2012	The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-alpha, IL-6, and IL-1beta.	Isoflurane	26-36	interleukin 1 beta	Mus musculus	94-102
22503062-6	2012	Vardenafil globally attenuated inflammatory responses in both genotypes however reduction of macrophage infiltration, macrophage chemoattractant chemokine and interleukin-1beta was observed in the CF group only.	Vardenafil Dihydrochloride	0-10	interleukin 1 beta	Mus musculus	159-176
22743370-9	2012	Interleukin 1beta expression was affected by BARKO and propranolol after TBI; attenuation of interleukin 6 and increased HSP70 expression were noted only with BARKO.	Propranolol	55-66	interleukin 1 beta	Mus musculus	0-17
21190757-4	2012	Here, we show that a clinically relevant isoflurane anesthesia increased the protein and messenger ribonucleic acid (mRNA) levels of TNF-alpha, IL-6, and IL-1beta in the brain tissues of mice.	Isoflurane	41-51	interleukin 1 beta	Mus musculus	154-162
22573549-6	2012	TNF-alpha and IL-1beta are the key cytokines involved in arthritis and also increase the activity of MMP-2 in RASF, which was antagonized by pretreatment with 15-LOX inhibitor PD146176 or knockdown of 15-LOX.	6,11-dihydro-5-thia-11-aza-benzo(a)-fluorene	176-184	interleukin 1 beta	Mus musculus	14-22
21190757-3	2012	We therefore set out to determine the effects of the common anesthetic isoflurane on the levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta, the proinflammatory cytokines, in vitro and in vivo, employing Western blot, immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), and reverse transcriptase polymerase chain reaction (RT-PCR).	Isoflurane	71-81	interleukin 1 beta	Mus musculus	158-166
22220695-8	2012	Formalin increased myeloperoxidase activity, and up-regulated TNF-alpha, IL-1beta and IL-6 in gastrocnemius.	Formaldehyde	0-8	interleukin 1 beta	Mus musculus	73-81
22575213-23	2012	Furthermore, dexamethasone and TTHL significantly reduced the TNF-alpha and IL-1beta levels in peritoneal fluid, whereas the IL-10 levels were unchanged.	Dexamethasone	13-26	interleukin 1 beta	Mus musculus	76-84
22511759-5	2012	Despite these data, the levels of the transcripts that encode the proinflammatory cytokines IL-1beta and TNF-alpha were reduced in phorbol 12-myristate 13-acetate-treated MCs developed from RasGRP4-null mice.	Tetradecanoylphorbol Acetate	131-162	interleukin 1 beta	Mus musculus	92-100
21794995-5	2012	RESULTS: We found that interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) expression increased significantly after noise exposure, and the expression was suppressed significantly in mice administered with geranylgeranylacetone (GGA), which activates HSF1.	geranylgeranylacetone	208-229	interleukin 1 beta	Mus musculus	48-65
21794995-5	2012	RESULTS: We found that interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) expression increased significantly after noise exposure, and the expression was suppressed significantly in mice administered with geranylgeranylacetone (GGA), which activates HSF1.	geranylgeranylacetone	208-229	interleukin 1 beta	Mus musculus	67-75
22548833-0	2012	Interleukin-1beta (IL-1beta) increases pain behavior and the blood glucose level: possible involvement of sympathetic nervous system.	Glucose	67-74	interleukin 1 beta	Mus musculus	0-17
22548833-0	2012	Interleukin-1beta (IL-1beta) increases pain behavior and the blood glucose level: possible involvement of sympathetic nervous system.	Glucose	67-74	interleukin 1 beta	Mus musculus	19-27
22548833-5	2012	IL-1beta injection caused an elevation of the blood glucose level.	Glucose	52-59	interleukin 1 beta	Mus musculus	0-8
22548833-9	2012	injection of IL-1beta enhanced the blood glucose level when mice were orally fed with d-glucose.	Glucose	41-48	interleukin 1 beta	Mus musculus	13-21
22548833-9	2012	injection of IL-1beta enhanced the blood glucose level when mice were orally fed with d-glucose.	Glucose	86-95	interleukin 1 beta	Mus musculus	13-21
22548833-15	2012	pretreatment with phentolamine (an alpha(1)-adrenergic blocker) or yohimbine (an alpha(2)-adrenergic blocker) significantly attenuated the blood glucose level and pain behavior induced by IL-1beta administered i.t.	Phentolamine	18-30	interleukin 1 beta	Mus musculus	188-196
22548833-15	2012	pretreatment with phentolamine (an alpha(1)-adrenergic blocker) or yohimbine (an alpha(2)-adrenergic blocker) significantly attenuated the blood glucose level and pain behavior induced by IL-1beta administered i.t.	Yohimbine	67-76	interleukin 1 beta	Mus musculus	188-196
22548833-15	2012	pretreatment with phentolamine (an alpha(1)-adrenergic blocker) or yohimbine (an alpha(2)-adrenergic blocker) significantly attenuated the blood glucose level and pain behavior induced by IL-1beta administered i.t.	Glucose	145-152	interleukin 1 beta	Mus musculus	188-196
22548833-16	2012	However, the blood glucose level and pain behavior were not affected by butoxamine (a beta(2)-adrenergic blocker), whereas metoprolol (a beta(2)-adrenergic blocker) enhanced IL-1beta-induced blood glucose level and pain behavior in mice fed with d-glucose.	Metoprolol	123-133	interleukin 1 beta	Mus musculus	174-182
22548833-16	2012	However, the blood glucose level and pain behavior were not affected by butoxamine (a beta(2)-adrenergic blocker), whereas metoprolol (a beta(2)-adrenergic blocker) enhanced IL-1beta-induced blood glucose level and pain behavior in mice fed with d-glucose.	Glucose	197-204	interleukin 1 beta	Mus musculus	174-182
22548833-16	2012	However, the blood glucose level and pain behavior were not affected by butoxamine (a beta(2)-adrenergic blocker), whereas metoprolol (a beta(2)-adrenergic blocker) enhanced IL-1beta-induced blood glucose level and pain behavior in mice fed with d-glucose.	Glucose	246-255	interleukin 1 beta	Mus musculus	174-182
22427602-4	2012	IL-1beta pellets were implanted in corneas of BALB/c mice that were then treated with dexamethasone or bevacizumab at different time points.	Dexamethasone	86-99	interleukin 1 beta	Mus musculus	0-8
22427602-7	2012	RESULTS: Dexamethasone inhibited IL-1beta-induced angiogenesis when treatment started 4 days after IL-1beta implantation, while bevacizumab only inhibited angiogenesis by day 2 after implantation.	Dexamethasone	9-22	interleukin 1 beta	Mus musculus	33-41
22427602-7	2012	RESULTS: Dexamethasone inhibited IL-1beta-induced angiogenesis when treatment started 4 days after IL-1beta implantation, while bevacizumab only inhibited angiogenesis by day 2 after implantation.	Dexamethasone	9-22	interleukin 1 beta	Mus musculus	99-107
22583898-6	2012	As a consequence, L-theanine inhibited oxidative stress-mediated inflammatory response which included the increase of TNF-alpha and IL-1beta in sera, and expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in livers.	theanine	18-28	interleukin 1 beta	Mus musculus	132-140
22427249-5	2012	Our results indicated that 7,8-DHF significantly attenuated secretion of LPS-induced inflammatory mediators nitric oxide (NO), prostaglandin E2 (PGE2) and interleukin-1beta (IL-1beta) in RAW264.7 cells.	6,7-dihydroxyflavone	27-34	interleukin 1 beta	Mus musculus	155-172
22547371-7	2012	The TG mice had significantly less pGSK3beta and HIF-1alpha, with more interleukin-1beta and total protein oxidation than wild-type controls, and for each protein, DFO treatment significantly reduced these differences.	Deferoxamine	164-167	interleukin 1 beta	Mus musculus	71-88
22502642-0	2012	Adenosine A2A receptor activation and hyaluronan fragment inhibition reduce inflammation in mouse articular chondrocytes stimulated with interleukin-1beta.	Hyaluronic Acid	38-48	interleukin 1 beta	Mus musculus	137-154
22502642-8	2012	Treatment of chondrocytes with the HA-blocking peptide Pep-1 and/or a specific A(2A)R agonist (CGS-21680) significantly reduced all of the inflammatory parameters upregulated by IL-1beta.	cysteinylglycine	95-98	interleukin 1 beta	Mus musculus	178-186
22427249-6	2012	Additionally, LPS-induced expression of inducible NO synthase (iNOS), cyclooxygenase (COX)-2 and IL-1beta was decreased by pre-treatment with 7,8-DHF.	6,7-dihydroxyflavone	142-149	interleukin 1 beta	Mus musculus	97-105
22427249-9	2012	These results suggest that the anti-inflammatory property of 7,8-DHF is related to the downregulation of iNOS, COX-2 and IL-1beta, due to NF-kappaB inhibition as well as to the negative regulation of MAPK activation in RAW264.7 cells.	6,7-dihydroxyflavone	61-68	interleukin 1 beta	Mus musculus	121-129
22427249-5	2012	Our results indicated that 7,8-DHF significantly attenuated secretion of LPS-induced inflammatory mediators nitric oxide (NO), prostaglandin E2 (PGE2) and interleukin-1beta (IL-1beta) in RAW264.7 cells.	6,7-dihydroxyflavone	27-34	interleukin 1 beta	Mus musculus	174-182
22633410-4	2012	The decrease in nitric oxide production was accompanied by a decrease in the transcripts of several proinflammatory cytokines, most dramatically interleukin-1beta.	Nitric Oxide	16-28	interleukin 1 beta	Mus musculus	145-162
22281546-8	2012	Furthermore, rSj16 also significantly decreased the levels of proinflammatory cytokines such as PGE2, IL-1beta, IL-6, IL-12, IL-23, and TNF-alpha, whereas it increased the levels of immunosuppressive cytokine IL-10.	rsj16	13-18	interleukin 1 beta	Mus musculus	102-110
22538477-4	2012	beta-Sitosterol also inhibited the expression of proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6, and an inflammatory enzyme, cyclooxygenase (COX)-2, in the colons of TNBS-induced colitic mice, as well as the activation of NF-kappaB.	gamma-sitosterol	0-15	interleukin 1 beta	Mus musculus	86-94
22483798-9	2012	Moreover, EnnB increased the release of interleukin-1 beta (IL-1beta) in cells primed with lipopolysaccharide (LPS), and this response was reduced by both ZYVAD-FMK and the cathepsin B inhibitor CA-074Me.	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone	155-164	interleukin 1 beta	Mus musculus	60-68
22403796-7	2012	Furthermore, the 5-FU-mediated upregulation of TNF-alpha, IL-1beta, and NOX1 and the production of reactive oxygen species were significantly attenuated in Nox1KO mice compared with that in WT mice.	Fluorouracil	17-21	interleukin 1 beta	Mus musculus	58-66
22483798-9	2012	Moreover, EnnB increased the release of interleukin-1 beta (IL-1beta) in cells primed with lipopolysaccharide (LPS), and this response was reduced by both ZYVAD-FMK and the cathepsin B inhibitor CA-074Me.	CA 074 methyl ester	195-203	interleukin 1 beta	Mus musculus	60-68
22483798-9	2012	Moreover, EnnB increased the release of interleukin-1 beta (IL-1beta) in cells primed with lipopolysaccharide (LPS), and this response was reduced by both ZYVAD-FMK and the cathepsin B inhibitor CA-074Me.	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone	155-164	interleukin 1 beta	Mus musculus	40-58
22366673-6	2012	RESULTS: We found that taraxasterol inhibited NO, PGE(2), TNF-alpha, IL-1beta and IL-6 production in LPS-induced RAW 264.7 macrophages in a dose-dependent manner.	taraxasterol	23-35	interleukin 1 beta	Mus musculus	69-77
22569158-11	2012	Histamine or H4R agonist also inhibited LPS-induced IL-1beta release in both N9 microglia cell line and hippocampal organotypic slice cultures.	Histamine	0-9	interleukin 1 beta	Mus musculus	52-60
22569158-13	2012	Altogether, our data suggest that histamine per se triggers microglia motility, whereas histamine impedes LPS-induced microglia migration and IL-1beta release.	Histamine	88-97	interleukin 1 beta	Mus musculus	142-150
22331028-8	2012	In contrast, IL-1beta only induced activation of the phosphatidylinositol (PI) 3-kinase/Akt pathway in WT neurons, but not in GRK6-/- neurons.	Phosphatidylinositols	53-73	interleukin 1 beta	Mus musculus	13-21
20737580-6	2012	Ex vivo IL-1beta production by peritoneal macrophages was elevated substantially at concentrations of &gt;= 5 mg PFOS/kg TAD.	perfluorooctane sulfonic acid	113-117	interleukin 1 beta	Mus musculus	8-16
22414473-13	2012	CONCLUSION: These results suggest that the anti-inflammatory properties of ethanol extract from ZJP might be the results from the inhibition of iNOS, COX-2, IL-6, IL-1beta, and TNF-alpha expression through preventing the nuclear translocation of the NF-kappaB p50 and p65 subunits in RAW 264.7 cells.	Ethanol	75-82	interleukin 1 beta	Mus musculus	163-171
22414473-13	2012	CONCLUSION: These results suggest that the anti-inflammatory properties of ethanol extract from ZJP might be the results from the inhibition of iNOS, COX-2, IL-6, IL-1beta, and TNF-alpha expression through preventing the nuclear translocation of the NF-kappaB p50 and p65 subunits in RAW 264.7 cells.	zjp	96-99	interleukin 1 beta	Mus musculus	163-171
22345171-8	2012	Accordingly, cellular cholesterol depletion (cyclodextrin) and silencing of caveolin-1 (small interfering RNA) inhibited IL-1beta-induced activation of p38-MAPK and MK2, as well as IL-1beta-induced tube formation and migration.	Cholesterol	22-33	interleukin 1 beta	Mus musculus	121-129
22345171-8	2012	Accordingly, cellular cholesterol depletion (cyclodextrin) and silencing of caveolin-1 (small interfering RNA) inhibited IL-1beta-induced activation of p38-MAPK and MK2, as well as IL-1beta-induced tube formation and migration.	Cyclodextrins	45-57	interleukin 1 beta	Mus musculus	121-129
22422705-7	2012	Those treated with DSS developed watery diarrhea and bloody stools, and showed body weight loss, spleen hypertrophy, and shortening of the colon, as well as deteriorations in survival rate, liver function, colon mucosal interleukin-1beta level and expression of phase II detoxification enzyme mRNA.	dss	19-22	interleukin 1 beta	Mus musculus	220-237
22763270-3	2012	Furthermore, the inhibitory effects of NA-COS on generation of interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha were determined.	na-cos	39-45	interleukin 1 beta	Mus musculus	63-85
20737580-7	2012	Moreover, PFOS exposure markedly enhanced the ex vivo production of TNF-alpha, IL-1beta and IL-6 by peritoneal and splenic macrophages when stimulated either in vitro or in vivo with lipopolysaccharide (LPS).	perfluorooctane sulfonic acid	10-14	interleukin 1 beta	Mus musculus	79-87
20737580-9	2012	PFOS exposure elevated the expression of pro-inflammatory cytokines TNF-alpha, IL-1beta, IL-6, and proto-oncogene, c-myc, in the spleen.	perfluorooctane sulfonic acid	0-4	interleukin 1 beta	Mus musculus	79-87
22401937-8	2012	Treatment with Gin-Re inhibited secretion levels of inflammatory mediators such as tumor necrosis factor alpha (TNF alpha), and interleukin-1beta (IL-1beta) in LPS-stimulated murine macrophage Raw 264.7 cells.	ginsenoside Re	15-21	interleukin 1 beta	Mus musculus	128-145
22401937-8	2012	Treatment with Gin-Re inhibited secretion levels of inflammatory mediators such as tumor necrosis factor alpha (TNF alpha), and interleukin-1beta (IL-1beta) in LPS-stimulated murine macrophage Raw 264.7 cells.	ginsenoside Re	15-21	interleukin 1 beta	Mus musculus	147-155
22387176-7	2012	Incubating BV-2 murine microglial cells with the PPARdelta agonist L-165041 prevented the radiation-induced increase in: (i) intracellular reactive oxygen species generation, (ii) Cox-2 and MCP-1 expression, and (iii) IL-1beta and TNF-alpha message levels.	4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid	67-75	interleukin 1 beta	Mus musculus	218-226
22860460-0	2012	[Regulation trend of resveratrol on TNFalpha-,IL-1beta, IL-6 expressions in bronchoalveolar lavage fluid of RSV-infected BALB/c mice].	Resveratrol	21-32	interleukin 1 beta	Mus musculus	46-54
22306981-4	2012	40 week MNU treatment induced increased expressions of inflammatory cytokines (IL-1beta, IL-6) of Bcl-2 at mRNA level and NFkappaB and IL-1beta at protein level.	Methylnitrosourea	8-11	interleukin 1 beta	Mus musculus	79-87
22306981-4	2012	40 week MNU treatment induced increased expressions of inflammatory cytokines (IL-1beta, IL-6) of Bcl-2 at mRNA level and NFkappaB and IL-1beta at protein level.	Methylnitrosourea	8-11	interleukin 1 beta	Mus musculus	135-143
22306981-7	2012	This study emphasizes that MNU, a harmful industrial and environmental pollutant, potentially activates inflammatory cytokines (IL-1beta, IL-6) in hepatic cells with increased expression of NFkappaB which might be responsible for hepatocarcinogenesis in Balb/c mice.	Methylnitrosourea	27-30	interleukin 1 beta	Mus musculus	128-136
22803375-0	2012	[Cinnamaldehyde decreases interleukin-1beta induced PGE2 production by down-regulation of mPGES-1 and COX-2 expression in mouse macrophage RAW264.7 cells].	cinnamaldehyde	1-15	interleukin 1 beta	Mus musculus	26-43
22803375-0	2012	[Cinnamaldehyde decreases interleukin-1beta induced PGE2 production by down-regulation of mPGES-1 and COX-2 expression in mouse macrophage RAW264.7 cells].	Dinoprostone	52-56	interleukin 1 beta	Mus musculus	26-43
22803375-7	2012	The experimental results suggested that cinnamaldehyde could evidently reverse the increased production of PGE2induced by IL-1beta.	cinnamaldehyde	40-54	interleukin 1 beta	Mus musculus	122-130
22803375-7	2012	The experimental results suggested that cinnamaldehyde could evidently reverse the increased production of PGE2induced by IL-1beta.	pge2induced	107-118	interleukin 1 beta	Mus musculus	122-130
22546005-0	2012	Maternal immune activation by poly I:C induces expression of cytokines IL-1beta and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain.	Poly I-C	30-38	interleukin 1 beta	Mus musculus	71-79
22515414-7	2012	RESULTS: Palmitate (PA) dose-dependently increased lipid accumulation, TG content and induced the secretion of interleukin-1beta (IL-1beta), IL-18, TNF-alpha and MCP-1 from HepG2 cells.	Palmitates	9-18	interleukin 1 beta	Mus musculus	111-128
22515414-7	2012	RESULTS: Palmitate (PA) dose-dependently increased lipid accumulation, TG content and induced the secretion of interleukin-1beta (IL-1beta), IL-18, TNF-alpha and MCP-1 from HepG2 cells.	Palmitates	9-18	interleukin 1 beta	Mus musculus	130-138
22515414-7	2012	RESULTS: Palmitate (PA) dose-dependently increased lipid accumulation, TG content and induced the secretion of interleukin-1beta (IL-1beta), IL-18, TNF-alpha and MCP-1 from HepG2 cells.	Palmitates	20-22	interleukin 1 beta	Mus musculus	111-128
22515414-7	2012	RESULTS: Palmitate (PA) dose-dependently increased lipid accumulation, TG content and induced the secretion of interleukin-1beta (IL-1beta), IL-18, TNF-alpha and MCP-1 from HepG2 cells.	Palmitates	20-22	interleukin 1 beta	Mus musculus	130-138
22474389-5	2012	Active IL-1beta remains elevated in CLIC4 knockout macrophages and in macrophages in which CLIC4 nuclear translocation is prevented by the NOS inhibitor l-NAME.	NG-Nitroarginine Methyl Ester	153-159	interleukin 1 beta	Mus musculus	7-15
22400806-8	2012	Enzyme-linked immunosorbent assay results indicated that Lico A can significantly down-regulate TNF-alpha, IL-6, and IL-1beta levels in vitro and in vivo, and treatment with Lico A significantly attenuated alveolar wall thickening, alveolar hemorrhage, interstitial edema, and inflammatory cells infiltration in mice with ALI.	licochalcone A	57-63	interleukin 1 beta	Mus musculus	117-125
22400806-8	2012	Enzyme-linked immunosorbent assay results indicated that Lico A can significantly down-regulate TNF-alpha, IL-6, and IL-1beta levels in vitro and in vivo, and treatment with Lico A significantly attenuated alveolar wall thickening, alveolar hemorrhage, interstitial edema, and inflammatory cells infiltration in mice with ALI.	licochalcone A	174-180	interleukin 1 beta	Mus musculus	117-125
22860460-1	2012	OBJECTIVE: To study the regulation trend of resveratrol on TNF-alpha, IL-1beta, IL-6 expressions in bronchoalveolar layage fluid (BALF) of RSV-infected BALB/c mice at different time points.	Resveratrol	44-55	interleukin 1 beta	Mus musculus	70-78
22860460-5	2012	01) after 24 hours of RSV infection, while the expression of TNF-alpha (P &lt; 0.01), IL-1beta (P &lt; 0.05), IL-6 (P &lt; 0.01) in the resveratrol group decreased notably compared with the model group.	Resveratrol	136-147	interleukin 1 beta	Mus musculus	86-94
22860460-9	2012	CONCLUSION: Resveratrol can inhibit the over expression of inflammatory factors TNF-alpha, IL-1beta, IL-6 in bronchoalveolar lavage fluid of RSV-induced BALB/c mice and keep them at a low level with the passing of infection time.	Resveratrol	12-23	interleukin 1 beta	Mus musculus	91-99
22387068-4	2012	We recently observed that methamphetamine exposure elevates the expression of the sleep-promoting cytokine, interleukin-1beta in CD11b-positive monocytes within the brain.	Methamphetamine	26-41	interleukin 1 beta	Mus musculus	108-125
22246000-13	2012	Our data show that ciclesonide inhibits IL-1beta- and TNFalpha-induced MCP-1 production from human ASM cells via a transcriptional mechanism involving inhibition of NF-kappaB binding.	ciclesonide	19-30	interleukin 1 beta	Mus musculus	40-48
22326488-4	2012	beta-caryophyllene dose-dependently ameliorated cisplatin-induced kidney dysfunction, morphological damage, and renal inflammatory response (chemokines MCP-1 and MIP-2, cytokines TNF-alpha and IL-1beta, adhesion molecule ICAM-1, and neutrophil and macrophage infiltration).	caryophyllene	0-18	interleukin 1 beta	Mus musculus	193-201
22249931-11	2012	Bosentan treatment also reduced joint damage, leukocyte infiltration and pro-inflammatory cytokine levels (IL-1beta, TNFalpha and IL-17) in the joint tissues.	Bosentan	0-8	interleukin 1 beta	Mus musculus	107-115
22253275-11	2012	QX314 also attenuated the stimulation-induced interleukin-1beta production.	QX-314	0-5	interleukin 1 beta	Mus musculus	46-63
22492039-5	2012	Cell culture work showed that lack of iron reduces the ability of microglia to express cytokines (TNF-alpha and IL-1beta) involved in remyelination.	Iron	38-42	interleukin 1 beta	Mus musculus	112-120
22212527-0	2012	Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1beta and enhancing NMDA signaling.	Sirolimus	9-18	interleukin 1 beta	Mus musculus	91-99
22084394-10	2012	Rapamycin treatment also maintained cartilage cellularity and decreased ADAMTS-5 and interleukin-1beta expression in articular cartilage.	Sirolimus	0-9	interleukin 1 beta	Mus musculus	85-102
22287559-6	2012	This tumor-promoting effect of prolonged bortezomib treatment was associated with perpetuation of urethane-induced inflammation and chronic upregulation of interleukin-1beta and proinflammatory C-X-C motif chemokine ligands (CXCL) 1 and 2 in the lungs.	Bortezomib	41-51	interleukin 1 beta	Mus musculus	156-173
22287559-8	2012	In this regard, RAW264.7 macrophages exposed to bortezomib showed increased expression of interleukin-1beta, CXCL1 and CXCL2.	Bortezomib	48-58	interleukin 1 beta	Mus musculus	90-107
21709053-5	2012	The combination of ATP plus ivermectin also decreased the intracellular concentration of potassium and promoted the secretion of IL-1beta.	Adenosine Triphosphate	19-22	interleukin 1 beta	Mus musculus	129-137
21709053-12	2012	This drug triggers a potassium efflux via a mechanism which does not involve purinergic receptors and generates, in consequence, the activation of caspase-1 and the secretion of IL-1beta.	Potassium	21-30	interleukin 1 beta	Mus musculus	178-186
22131195-8	2012	AMP also affected the serum NO, TNF-alpha and IL-1beta levels at 5 h after Carr injection.	Adenosine Monophosphate	0-3	interleukin 1 beta	Mus musculus	46-54
22405772-5	2012	Treatment of mouse macrophage RAW264.7 cells with 1mM ATP induced high mobility group box 1 (HMGB1) release and IL-1beta production via activation of P2X7 receptor.	Adenosine Triphosphate	54-57	interleukin 1 beta	Mus musculus	112-120
22563255-4	2012	THC also suppressed LPS-induced overproduction of pro-inflammatory cytokines such as IL-1beta and TNF-alpha in BV2 microgilal cells.	Dronabinol	0-3	interleukin 1 beta	Mus musculus	85-93
22201039-8	2012	Maneb and paraquat induced the number of degenerating dopaminergic neurons, microglial cells, nitrite content, expressions of IL-1beta, p38 MAPK, NF-kB and TK and caffeine co-treatment reduced the level of such alterations.	Maneb	0-5	interleukin 1 beta	Mus musculus	126-134
22201039-8	2012	Maneb and paraquat induced the number of degenerating dopaminergic neurons, microglial cells, nitrite content, expressions of IL-1beta, p38 MAPK, NF-kB and TK and caffeine co-treatment reduced the level of such alterations.	Paraquat	10-18	interleukin 1 beta	Mus musculus	126-134
22543141-7	2012	CONCLUSION: ZL-5010 administered by gavage has anti-inflammatory and analgesic effects in mice and rats, and in mouse peritoneal exudate cell cultures, the agent also inhibits the production of the pro-inflammatory cytokines IL-1beta and TNF-alpha.	diethyl 1,3-dicyclohexyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate	12-19	interleukin 1 beta	Mus musculus	225-233
22405772-6	2012	Knockdown of P2X4 receptor or removal of extracellular Ca(2+) suppressed ATP-induced release of both HMGB1 and IL-1beta.	Adenosine Triphosphate	73-76	interleukin 1 beta	Mus musculus	111-119
22285467-12	2012	Hepatic expressions of IL-1beta mRNA and plasma IL-1beta were significantly increased soon after the diclofenac administration.	Diclofenac	101-111	interleukin 1 beta	Mus musculus	23-31
22439811-0	2012	Acute morphine activates satellite glial cells and up-regulates IL-1beta in dorsal root ganglia in mice via matrix metalloprotease-9.	Morphine	6-14	interleukin 1 beta	Mus musculus	64-72
22439811-4	2012	We examined acute morphine-induced activation of satellite glial cells (SGCs) and up-regulation of IL-1beta in dorsal root ganglia (DRGs), and further investigated the involvement of MMP-9 in these opioid-induced peripheral changes.	Morphine	18-26	interleukin 1 beta	Mus musculus	99-107
22439811-6	2012	The acute morphine-induced GFAP expression is transient, peaking at 2 h and declining after 3 h. Acute morphine treatment also increased IL-1beta immunoreactivity in SGCs and IL-1beta activation in DRGs.	Morphine	10-18	interleukin 1 beta	Mus musculus	137-145
22439811-6	2012	The acute morphine-induced GFAP expression is transient, peaking at 2 h and declining after 3 h. Acute morphine treatment also increased IL-1beta immunoreactivity in SGCs and IL-1beta activation in DRGs.	Morphine	10-18	interleukin 1 beta	Mus musculus	175-183
22439811-6	2012	The acute morphine-induced GFAP expression is transient, peaking at 2 h and declining after 3 h. Acute morphine treatment also increased IL-1beta immunoreactivity in SGCs and IL-1beta activation in DRGs.	Morphine	103-111	interleukin 1 beta	Mus musculus	137-145
22439811-6	2012	The acute morphine-induced GFAP expression is transient, peaking at 2 h and declining after 3 h. Acute morphine treatment also increased IL-1beta immunoreactivity in SGCs and IL-1beta activation in DRGs.	Morphine	103-111	interleukin 1 beta	Mus musculus	175-183
22439811-9	2012	Importantly, morphine-induced DRG up-regulation of GFAP expression and IL-1beta activation was abolished after Mmp9 deletion or naloxone pre-treatment.	Morphine	13-21	interleukin 1 beta	Mus musculus	71-79
22439811-9	2012	Importantly, morphine-induced DRG up-regulation of GFAP expression and IL-1beta activation was abolished after Mmp9 deletion or naloxone pre-treatment.	Naloxone	128-136	interleukin 1 beta	Mus musculus	71-79
22439811-10	2012	Finally, intrathecal injections of IL-1beta-selective siRNA not only reduced DRG IL-1beta expression but also prolonged acute morphine-induced analgesia.	Morphine	126-134	interleukin 1 beta	Mus musculus	35-43
22323544-2	2012	In this work, we demonstrate that L. interrogans induces NLRP3 inflammasome-dependent secretion of IL-1beta through the alteration of potassium transport in bone marrow-derived macrophages.	Potassium	134-143	interleukin 1 beta	Mus musculus	99-107
22327078-4	2012	Treatment with nigericin during influenza infection augmented IL-1beta production, increased caspase-1 activity, and decreased morbidity and mortality in elderly mice.	Nigericin	15-24	interleukin 1 beta	Mus musculus	62-70
22361326-9	2012	Injection of recombinant IL-1beta into caspase-1-deficient mice restored the ability of LCWE to cause coronary lesions in response to LCWE.	lcwe	88-92	interleukin 1 beta	Mus musculus	25-33
22439811-11	2012	CONCLUSIONS: Acute morphine induces opioid receptors- and MMP-9-dependent up-regulation of GFAP expression and IL-1beta activation in SGCs of DRGs.	Morphine	19-27	interleukin 1 beta	Mus musculus	111-119
22441335-3	2012	The results showed that pretreatment with 10, 20 or 40 mug/mL of 7-O-methylnaringenin could downregulate tumour necrosis factor (TNF-alpha), interleukin (IL-6) and interleukin (IL-1beta) in a dose-dependent manner.	sakuranetin	65-85	interleukin 1 beta	Mus musculus	177-185
22441336-5	2012	RA significantly decreased the production of LPS-induced TNF-a, IL-6, and IL-1beta compare with the LPS group.	rosmarinic acid	0-2	interleukin 1 beta	Mus musculus	74-82
22285467-12	2012	Hepatic expressions of IL-1beta mRNA and plasma IL-1beta were significantly increased soon after the diclofenac administration.	Diclofenac	101-111	interleukin 1 beta	Mus musculus	48-56
22285467-13	2012	Then, the results of an in vivo neutralization study of IL-1beta suggested that IL-1beta was involved early in the time of pathogenesis of the diclofenac-induced liver injury.	Diclofenac	143-153	interleukin 1 beta	Mus musculus	56-64
22285467-13	2012	Then, the results of an in vivo neutralization study of IL-1beta suggested that IL-1beta was involved early in the time of pathogenesis of the diclofenac-induced liver injury.	Diclofenac	143-153	interleukin 1 beta	Mus musculus	80-88
22285467-14	2012	In conclusion, we firstly developed a diclofenac-induced acute liver injury model in normal mice, and the involvement of IL-17 and IL-1beta was clarified.	Diclofenac	38-48	interleukin 1 beta	Mus musculus	131-139
22182752-5	2012	The administration of MHSNs at 50 mg/kg increased liver injury markers in serum, such as alanine aminotransferase (ALT), inflammatory cytokines interleukin-1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	mhsns	22-27	interleukin 1 beta	Mus musculus	144-162
22230470-11	2012	Furthermore, DS enhanced the expression of HO-1 and suppressed that of IL-1beta and TNF-alpha in inflamed mouse lungs.	ds	13-15	interleukin 1 beta	Mus musculus	71-79
22209879-4	2012	These thienopyridine analogs also inhibited the proinflammatory mediators such as Tumor necrosis factor (TNF)-alpha, Interleukin (IL)-1beta and Nitric Oxide (NO) in Lipopolysaccharide (LPS) challenged murine macrophages.	thienopyridine	6-20	interleukin 1 beta	Mus musculus	117-139
22182752-5	2012	The administration of MHSNs at 50 mg/kg increased liver injury markers in serum, such as alanine aminotransferase (ALT), inflammatory cytokines interleukin-1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	mhsns	22-27	interleukin 1 beta	Mus musculus	164-172
22803143-1	2012	Experiments on outbred albino mice have shown that proserine (reversible cholinesterase inhibitor) and nicotine (nicotinic receptor agonist) in a equivalent dose of 0.2 DL(50)injected 2 h before sepsis induction significantly reduced animal mortality from experimental infection due to reduction of blood concentrations of proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6.	Neostigmine	51-60	interleukin 1 beta	Mus musculus	360-368
22803143-1	2012	Experiments on outbred albino mice have shown that proserine (reversible cholinesterase inhibitor) and nicotine (nicotinic receptor agonist) in a equivalent dose of 0.2 DL(50)injected 2 h before sepsis induction significantly reduced animal mortality from experimental infection due to reduction of blood concentrations of proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6.	Nicotine	103-111	interleukin 1 beta	Mus musculus	360-368
22339795-8	2012	In in vitro study, we also found that 4-O-methylhonokiol suppressed the expression of iNOS and COX-2 as well as the production of reactive oxygen species, nitric oxide, prostaglandin E2, tumor necrosis factor-alpha, and interleukin-1beta in the LPS-stimulated cultured astrocytes.	4-O-methylhonokiol	38-56	interleukin 1 beta	Mus musculus	220-237
22207130-0	2012	IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1beta by keratinocytes via the ROS-NLRP3-caspase-1 pathway.	Reactive Oxygen Species	108-111	interleukin 1 beta	Mus musculus	74-82
22207130-5	2012	RESULTS: We found that treatment with IL-17 and IL-22 causes an increase in IL-1beta via the activation of NLRP3 by a process that involves the generation of reactive oxygen species.	Reactive Oxygen Species	158-181	interleukin 1 beta	Mus musculus	76-84
22325176-10	2012	mRNA expression levels of the pro-inflammatory cytokines, such as IL-1beta, TNF-alpha, IL-6, IL-12p40, IL-17, and MCP-1 were also suppressed by DHMEQ administration.	dehydroxymethylepoxyquinomicin	144-149	interleukin 1 beta	Mus musculus	66-74
22755107-5	2012	In the anti-inflammatory studies, the EPA-GC nanoparticles significantly inhibited lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production and interleukin-1 beta (IL-1 beta) secretion in RAW 264.7 cells.	Eicosapentaenoic Acid	38-41	interleukin 1 beta	Mus musculus	152-170
22755107-5	2012	In the anti-inflammatory studies, the EPA-GC nanoparticles significantly inhibited lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production and interleukin-1 beta (IL-1 beta) secretion in RAW 264.7 cells.	Eicosapentaenoic Acid	38-41	interleukin 1 beta	Mus musculus	172-181
22755107-5	2012	In the anti-inflammatory studies, the EPA-GC nanoparticles significantly inhibited lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production and interleukin-1 beta (IL-1 beta) secretion in RAW 264.7 cells.	glycol-chitosan	42-44	interleukin 1 beta	Mus musculus	152-170
22755107-5	2012	In the anti-inflammatory studies, the EPA-GC nanoparticles significantly inhibited lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production and interleukin-1 beta (IL-1 beta) secretion in RAW 264.7 cells.	glycol-chitosan	42-44	interleukin 1 beta	Mus musculus	172-181
22155353-2	2012	Both Au and SiAu significantly increased the release of Ca, hydrogen peroxide, NO, IL-1alpha, IL-1beta, IL-6, IL-10, IP-10, MCP-1, MCP-3, TNF-alpha, RANTES, G-CSF, GM-CSF, LIF, MIP-2, VEGF, and PGE2 with enhancing expression of STAT1, STAT3, c-Fos, and COX-2 mRNA in RAW 264.7 cells.	Gold	5-7	interleukin 1 beta	Mus musculus	94-102
22192524-9	2012	The observed increase in plasma homocysteine during prolonged betaine treatment was accompanied by a significant increase in the plasma levels of TNF-alpha and IL-1beta and reversion to a hypercoagulative phenotype.	Homocysteine	32-44	interleukin 1 beta	Mus musculus	160-168
22192524-9	2012	The observed increase in plasma homocysteine during prolonged betaine treatment was accompanied by a significant increase in the plasma levels of TNF-alpha and IL-1beta and reversion to a hypercoagulative phenotype.	Betaine	62-69	interleukin 1 beta	Mus musculus	160-168
22220511-8	2012	Finally, enhancement of astrocytic system xc- expression and function via IL-1beta (interleukin-1beta) exposure potentiates hypoglycaemic neuronal death, the process of which is prevented by removal of l-cystine and/or addition of system xc- inhibitors.	Cystine	202-211	interleukin 1 beta	Mus musculus	74-82
22192912-0	2012	Hyaluronan in part mediates IL-1beta-induced inflammation in mouse chondrocytes by up-regulating CD44 receptors.	Hyaluronic Acid	0-10	interleukin 1 beta	Mus musculus	28-36
22220511-8	2012	Finally, enhancement of astrocytic system xc- expression and function via IL-1beta (interleukin-1beta) exposure potentiates hypoglycaemic neuronal death, the process of which is prevented by removal of l-cystine and/or addition of system xc- inhibitors.	Cystine	202-211	interleukin 1 beta	Mus musculus	84-101
22138579-7	2012	The A(2A) receptor agonist, CGS21680, inhibited osteoclast differentiation and function (half maximal inhibitory concentration, 50 nmol/L), increased the percentage of immature osteoclast precursors, and decreased IL-1beta and tumor necrosis factor-alpha secretion, an effect that was reversed by the A(2A) antagonist, ZM241385.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	28-36	interleukin 1 beta	Mus musculus	214-254
21790535-8	2012	KEY RESULTS: DS, when administered for 7 days, showed intestinal anti-inflammatory effects in TNBS-induced colitis; these effects were observed both macroscopically and through the profile of inflammatory mediators (TNF, IL-1beta, IL-6 and IL-17).	dersalazine	13-15	interleukin 1 beta	Mus musculus	221-229
21983279-6	2012	Hippocampal inflammation in the IL-1beta(XAT) model severely impaired doublecortin (DCX) positive cells at 1 and 3 months after IL-1beta induction.	doublecortin	70-82	interleukin 1 beta	Mus musculus	32-40
21983279-7	2012	Furthermore, BrdU labeling demonstrated a shift in cell lineage from neuronal to astroglial in the context of sustained hippocampal IL-1beta overexpression.	Bromodeoxyuridine	13-17	interleukin 1 beta	Mus musculus	132-140
21790535-10	2012	DS showed beneficial effects on DSS-induced colitis in C57BL/6 mice and reduced colonic pro-inflammatory cytokines IL-1beta, IL-6 and IL-17.	dersalazine	0-2	interleukin 1 beta	Mus musculus	115-123
22155313-0	2012	Carbon nanotubes provoke inflammation by inducing the pro-inflammatory genes IL-1beta and IL-6.	Carbon	0-6	interleukin 1 beta	Mus musculus	77-85
21465277-3	2012	A WI methanolic extract significantly inhibited NO, PGE(2), IL-6, IL-1beta, and TNF-alpha production in LPS-stimulated RAW 264.7 cells.	methanolic	5-15	interleukin 1 beta	Mus musculus	66-74
21400122-8	2012	Mice treated with midazolam had significantly lower serum IL-1beta (p=0.002), TNF-alpha (p=0.002), IL-6 (p=0.016), IL-10 (p=0.009), and TGF-beta (p=0.004) than saline-treated mice, with little impact on serum chemokine levels.	Midazolam	18-27	interleukin 1 beta	Mus musculus	58-66
21336676-3	2012	Dexamethasone (50 mug/ear), azithromycin, and clarithromycin (500 mug/ear) reduced TNF-alpha and interleukin (IL)-1beta concentration in ear tissue by inhibiting inflammatory cell accumulation in PMA-induced inflammation.	Dexamethasone	0-13	interleukin 1 beta	Mus musculus	97-119
21336676-3	2012	Dexamethasone (50 mug/ear), azithromycin, and clarithromycin (500 mug/ear) reduced TNF-alpha and interleukin (IL)-1beta concentration in ear tissue by inhibiting inflammatory cell accumulation in PMA-induced inflammation.	Azithromycin	28-40	interleukin 1 beta	Mus musculus	97-119
21336676-3	2012	Dexamethasone (50 mug/ear), azithromycin, and clarithromycin (500 mug/ear) reduced TNF-alpha and interleukin (IL)-1beta concentration in ear tissue by inhibiting inflammatory cell accumulation in PMA-induced inflammation.	Clarithromycin	46-60	interleukin 1 beta	Mus musculus	97-119
22161143-7	2012	Dehydroxy methyl epoxyquinomicin, a selective inhibitor of NFkappaB, partially inhibited the enhancement of fibronectin expression by TGF-beta, TNF-alpha, and IL-1beta, but not of N-cadherin expression.	dehydroxymethylepoxyquinomicin	0-32	interleukin 1 beta	Mus musculus	159-167
21468627-10	2012	Exogenous IL-4 also attenuated TNF-alpha, IL-1beta, iNOS, and COX-2 expressions in ifosfamide-treated bladders.	Ifosfamide	83-93	interleukin 1 beta	Mus musculus	42-50
22032869-6	2012	Additionally, oral treatment with (-)-cassine (3-60 mg/kg) prevented the mechanical hyperalgesia elicited by intraplantar injection of prostaglandin E(2), complete Freund"s adjuvant, interleukin-1beta, interleukin-6 and keratinocyte-derived chemokine.	cassine	34-45	interleukin 1 beta	Mus musculus	183-200
22147847-3	2012	Recent investigations revealed that airway exposure to allergen in sensitized individuals causes the release of ATP and uric acid, activating the NLRP3 inflammasome complex and cleaving pro-IL-1beta to mature IL-1beta through caspase-1.	Adenosine Triphosphate	112-115	interleukin 1 beta	Mus musculus	190-198
22147847-3	2012	Recent investigations revealed that airway exposure to allergen in sensitized individuals causes the release of ATP and uric acid, activating the NLRP3 inflammasome complex and cleaving pro-IL-1beta to mature IL-1beta through caspase-1.	Adenosine Triphosphate	112-115	interleukin 1 beta	Mus musculus	209-217
22147847-3	2012	Recent investigations revealed that airway exposure to allergen in sensitized individuals causes the release of ATP and uric acid, activating the NLRP3 inflammasome complex and cleaving pro-IL-1beta to mature IL-1beta through caspase-1.	Uric Acid	120-129	interleukin 1 beta	Mus musculus	190-198
22147847-3	2012	Recent investigations revealed that airway exposure to allergen in sensitized individuals causes the release of ATP and uric acid, activating the NLRP3 inflammasome complex and cleaving pro-IL-1beta to mature IL-1beta through caspase-1.	Uric Acid	120-129	interleukin 1 beta	Mus musculus	209-217
22379572-7	2012	RESULTS: Manassantin B inhibited the production of IL-1beta and attenuated the phosphorylations of ERK1/2 and p38 MAPK, but not that of JNK, in RAW 264.7 cells treated with LPS.	manassantin B	9-22	interleukin 1 beta	Mus musculus	51-59
22051147-8	2012	Moreover, the joint production of TNF-alpha, IL-1beta and CXCL1/KC by zymosan was dependent on TLR2/MyD88 signaling.	Zymosan	70-77	interleukin 1 beta	Mus musculus	45-53
22179028-0	2012	A potential role of chondroitin sulfate on bone in osteoarthritis: inhibition of prostaglandin E2 and matrix metalloproteinases synthesis in interleukin-1beta-stimulated osteoblasts.	Chondroitin Sulfates	20-39	interleukin 1 beta	Mus musculus	141-158
22179028-1	2012	OBJECTIVES: To determine the effect of chondroitin sulfate (CS) on inflammatory mediators and proteolytic enzymes induced by interleukin-1beta (IL-1beta) and related to cartilage catabolism in murine osteoblasts.	Chondroitin Sulfates	39-58	interleukin 1 beta	Mus musculus	125-142
22179028-1	2012	OBJECTIVES: To determine the effect of chondroitin sulfate (CS) on inflammatory mediators and proteolytic enzymes induced by interleukin-1beta (IL-1beta) and related to cartilage catabolism in murine osteoblasts.	Chondroitin Sulfates	39-58	interleukin 1 beta	Mus musculus	144-152
22179028-1	2012	OBJECTIVES: To determine the effect of chondroitin sulfate (CS) on inflammatory mediators and proteolytic enzymes induced by interleukin-1beta (IL-1beta) and related to cartilage catabolism in murine osteoblasts.	Chondroitin Sulfates	60-62	interleukin 1 beta	Mus musculus	125-142
22179028-1	2012	OBJECTIVES: To determine the effect of chondroitin sulfate (CS) on inflammatory mediators and proteolytic enzymes induced by interleukin-1beta (IL-1beta) and related to cartilage catabolism in murine osteoblasts.	Chondroitin Sulfates	60-62	interleukin 1 beta	Mus musculus	144-152
22179028-7	2012	Interestingly, 7 days of CS treatment significantly counteracted IL-1beta-induced expression of COX-2 (-62%, P&lt;0.001), mPGES-1 (-63%, P&lt;0.001), MMP-3 (-39%, P=0.08), MMP-13 (-60%, P&lt;0.001) and RANKL (-84%, P&lt;0.001).	Chondroitin Sulfates	25-27	interleukin 1 beta	Mus musculus	65-73
22179028-8	2012	Accordingly, IL-1beta-induced PGE2, MMP-3 and MMP-13 releases were inhibited by 86% (P&lt;0.001), 58%(P&lt;0.001) and 38% (P&lt;0.01) respectively.	Dinoprostone	30-34	interleukin 1 beta	Mus musculus	13-21
21967771-5	2012	The results of DNA microarray analysis of ileal and colonic samples indicated that BB6378 increased the gene expression of interleukin (IL)-1alpha and IL-1beta, and IL-1alpha content in colonic explants was significantly increased after 20 h of culture with BB6378.	bb6378	83-89	interleukin 1 beta	Mus musculus	151-159
21561314-7	2012	Carprofen significantly reduced lesion size (p=0.002), decreased water content in the lesioned cortex (p=0.03), reduced the number of microglia in the lesioned cortex (p&lt;0.0001), and lowered the levels of proinflammatory cytokines (IL-1beta, p=0.03; IL-6, p=0.02).	carprofen	0-9	interleukin 1 beta	Mus musculus	235-243
22119385-7	2012	DMF suppressed production of nitric oxide (NO), prostaglandin E2 (PGE(2)), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), through extracellular signal-regulated kinase (ERK) pathway dependent HO-1 expression.	6,4'-dihydroxy-7-methoxyflavanone	0-3	interleukin 1 beta	Mus musculus	119-136
22119385-7	2012	DMF suppressed production of nitric oxide (NO), prostaglandin E2 (PGE(2)), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), through extracellular signal-regulated kinase (ERK) pathway dependent HO-1 expression.	6,4'-dihydroxy-7-methoxyflavanone	0-3	interleukin 1 beta	Mus musculus	138-146
22117528-4	2012	Naringenin treatments dose-dependently reduced renal tumor necrosis factor-alpha level and expression (P &lt; 0.05) but only at 1 and 2% significantly decreased production and expression of interleukin (IL)-1beta, IL-6, and monocyte chemoattractant protein-1 (P &lt; 0.05).	naringenin	0-10	interleukin 1 beta	Mus musculus	190-212
22822676-6	2012	They both could antagonize immunosuppressive action caused by Cyclophosphamide, which could promote T lymphocyte proliferation, kill and wound activity, quantity of T lymphocyte subgroup, and production of IL-1beta with different degree.	Cyclophosphamide	62-78	interleukin 1 beta	Mus musculus	206-214
22041103-9	2012	However, administration of DR-W extract in CIA mice significantly reduced arthritic scores and serum levels of anti-CII IgG2a antibody, PGE(2), TNF-alpha, IL-1beta and IL-6 compared with those in vehicle-treated CIA mice.	dr-w	27-31	interleukin 1 beta	Mus musculus	155-163
22466555-4	2012	Treatment with HSYA also alleviated bleomycin-induced increase of mRNA level of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and transforming growth factor (TGF)-beta1 in lung homogenates.	hydroxysafflor yellow A	15-19	interleukin 1 beta	Mus musculus	115-137
21898357-9	2012	Treatment of arthritic mice with the DP1 antagonist MK0524 soon after the onset of disease increased the incidence and severity of CIA as well as the local levels of IL-1beta, CXCL-1, and PGE2, whereas IL-10 levels were reduced.	MK-0524	52-58	interleukin 1 beta	Mus musculus	166-174
21928088-11	2012	The expression of TNF-alpha and interleukin (IL)-1beta were increased in the GalN/LPS group.	Galactosamine	77-81	interleukin 1 beta	Mus musculus	32-54
22041028-8	2012	Monocyte depletion with clodronate restored the endothelial response to IL-1beta in Psgl-1(-/-) mice.	Clodronic Acid	24-34	interleukin 1 beta	Mus musculus	72-80
22466555-4	2012	Treatment with HSYA also alleviated bleomycin-induced increase of mRNA level of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and transforming growth factor (TGF)-beta1 in lung homogenates.	Bleomycin	36-45	interleukin 1 beta	Mus musculus	115-137
24116272-9	2012	Baicalin and its metabolites also inhibited the expression of pro-inflammatory cytokines, TNF-alpha and IL-1beta, and the activation of NF-kappaB in LPS-stimulated peritoneal macrophages.	baicalin	0-8	interleukin 1 beta	Mus musculus	104-112
24116274-4	2012	WIN-34B inhibited the level of IL-6, PGE2, and MMP-13 in IL-1beta-stimulated RA FLSs in a dose-dependent manner.	Dinoprostone	37-41	interleukin 1 beta	Mus musculus	57-65
22687535-1	2012	Citreorosein (CIT), an anthraquinone component of Polygoni cuspidati (P. cuspidati) radix, suppressed gene expression of proinflammatory cytokines including tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta in mouse bone marrow-derived mast cells (BMMCs) stimulated with phorbol 12-myristate 13-acetate (PMA) plus the calcium ionophore A23187.	citreorosein	0-12	interleukin 1 beta	Mus musculus	215-223
22687535-1	2012	Citreorosein (CIT), an anthraquinone component of Polygoni cuspidati (P. cuspidati) radix, suppressed gene expression of proinflammatory cytokines including tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta in mouse bone marrow-derived mast cells (BMMCs) stimulated with phorbol 12-myristate 13-acetate (PMA) plus the calcium ionophore A23187.	citreorosein	14-17	interleukin 1 beta	Mus musculus	215-223
21675966-9	2012	Treatment with A-438079 also prevented the increase of urinary bladder myeloperoxidase activity and macrophage migration induced by cyclophosphamide and reduced the tissue levels of IL-1beta and TNF-alpha.	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine	15-23	interleukin 1 beta	Mus musculus	182-190
24116274-6	2012	The level of PGE2, NO, IL-1beta, and TNF-alpha were inhibited by WIN-34B at different concentrations in LPS-stimulated RAW264.7 cells.	carpropamid	65-68	interleukin 1 beta	Mus musculus	23-31
24116274-6	2012	The level of PGE2, NO, IL-1beta, and TNF-alpha were inhibited by WIN-34B at different concentrations in LPS-stimulated RAW264.7 cells.	34b	69-72	interleukin 1 beta	Mus musculus	23-31
21807089-5	2012	Resveratrol lessened the colitis-associated decrease in body weight and increased levels of serum amyloid A (SAA), CXCL10 and colon TNF-alpha, IL-6, RANTES, IL-12 and IL-1beta concentrations.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	167-175
22991570-8	2012	Additionally, CR(MeOH) also decreased IL-1beta, IL-6, NFkappaB, TNF-alpha, COX-2, and iNOS levels.	Chromium	14-16	interleukin 1 beta	Mus musculus	38-46
22975507-6	2012	Ginsenoside Rg3 at 20 and 30 mg/kg oral doses significantly attenuated up-regulation of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and IL-6 mRNA in brain tissue at 4 h after LPS injection.	Ginsenosides	0-11	interleukin 1 beta	Mus musculus	129-147
22975507-6	2012	Ginsenoside Rg3 at 20 and 30 mg/kg oral doses significantly attenuated up-regulation of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and IL-6 mRNA in brain tissue at 4 h after LPS injection.	Ginsenosides	0-11	interleukin 1 beta	Mus musculus	149-157
22991570-8	2012	Additionally, CR(MeOH) also decreased IL-1beta, IL-6, NFkappaB, TNF-alpha, COX-2, and iNOS levels.	Methanol	17-21	interleukin 1 beta	Mus musculus	38-46
22106404-6	2012	Nx-induced increases in circulating and renal tumor necrosis factor 1alpha and renal interleukin 1beta and monocyte chemoattractant protein 1 expressions were all remarkably attenuated or abolished by mPGES-1 deletion.	nx	0-2	interleukin 1 beta	Mus musculus	85-102
22155740-9	2012	RESULTS: Administration of parthenolide significantly reduced the severity of DSS-induced colitis as assessed by DAI and histological score, and resulted in downregulation of MPO activity and phospho-NF-kappaB p65 expression by the blockade of phosphorylation and subsequent degradation of IkappaB protein, strikingly reduced the production of TNF-alpha and IL-1beta.	parthenolide	27-39	interleukin 1 beta	Mus musculus	358-366
22536278-4	2012	In addition, the anti-inflammatory effects of NNMBS275 were demonstrated by the suppression of proinflammatory mediators, including proinflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2) and cytokines (tumor necrosis factor-alpha and interleukin-1beta).	nnmbs275	46-54	interleukin 1 beta	Mus musculus	258-275
22178196-4	2012	The results showed that alpinetin markedly inhibited the LPS- induced TNF-alpha, IL-6 and IL-1beta production both in vitro and vivo.	alpinetin	24-33	interleukin 1 beta	Mus musculus	90-98
21856425-4	2012	In the PTZ seizure model, the incidence of acute convulsive seizures was increased in both Il1b and Il1r1-/- mice compared to their respective +/+ littermate controls.	Pentylenetetrazole	7-10	interleukin 1 beta	Mus musculus	91-95
21881556-7	2012	We found that in wild-type mice, CG treatment increased peritoneal permeability (measured by equilibration), increased mRNA expression of TGF-beta1, connective tissue growth factor and fibronectin, TNF-alpha and IL-1beta expression, and resulted in infiltration of CD3-positive T cells, and caused a high number of Ki-67-positive proliferating cells.	chlorhexidine gluconate	33-35	interleukin 1 beta	Mus musculus	212-220
23125487-8	2012	RESULTS: A significant improvement was observed in DAI and histological score in mice treated with picroliv, and incerased MPO activity, MDA concentrations, and the expression of IL-1beta, TNF-alpha, and NF-kappaB p65 in mice with DSS-induced colitis were significantly reduced while decreased SOD level increased following administration of picroliv.	kutkin	99-107	interleukin 1 beta	Mus musculus	179-187
23209347-3	2012	We also demonstrated that OA-induced pulmonary injury is dependent on ERK1/2 activation, since U0126, an inhibitor of ERK1/2 phosphorylation, blocked neutrophil migration, oedema, and lipid body formation as well as IL-6, but not IL-1beta production.	U 0126	95-100	interleukin 1 beta	Mus musculus	230-238
22355243-14	2012	Conjunctival IL-1beta, IL-2, IL-6, IL-17, tumor necrosis factor-alpha (TNF-alpha), and MMP-9 mRNA expression was lower in the ICES+TT group than in the ICES or ICES+PBS group.	6-thiotheophylline	131-133	interleukin 1 beta	Mus musculus	13-21
22919282-0	2012	Constitutive over expression of IL-1beta, IL-6, NF-kappaB, and Stat3 is a potential cause of lung tumorgenesis in urethane (ethyl carbamate) induced Balb/c mice.	Urethane	114-122	interleukin 1 beta	Mus musculus	32-40
22919282-0	2012	Constitutive over expression of IL-1beta, IL-6, NF-kappaB, and Stat3 is a potential cause of lung tumorgenesis in urethane (ethyl carbamate) induced Balb/c mice.	Urethane	124-139	interleukin 1 beta	Mus musculus	32-40
22124125-7	2012	Inhibiting the expression of GILZ in RAW264.7 cells using specific GILZ small interfering RNA led to a significant increase in mRNA production and protein secretion of IL-1beta and IL-6 in hypoxia and abrogated the inhibitory effect of Dex on expression of IL-1beta and IL-6 in hypoxia.	Dexamethasone	236-239	interleukin 1 beta	Mus musculus	168-176
21695504-5	2012	Mustard oil-evoked acute neurogenic plasma protein extravasation in the rat hindpaw skin, carrageenan-induced mouse paw edema, mechanical hyperalgesia, and IL-1beta, tumor necrosis factor-alpha production, as well as mild heat injury-evoked thermal hyperalgesia were similarly attenuated by both peptides.	mustard oil	0-11	interleukin 1 beta	Mus musculus	156-193
22815633-6	2012	In the BTX-B-injected mice, immunofluorescent staining for TNF-alpha and IL-1beta in corneal and conjunctival epithelial cells increased significantly at the 2 and 4 week time points compared to that of normal and saline-injected mice, and returned to normal levels at the 4 week time point.	btx-b	7-12	interleukin 1 beta	Mus musculus	73-81
22815633-8	2012	Topical fluorometholone significantly decreased the staining of TNF-alpha and IL-1beta in corneal and conjunctival epithelia after 1-week treatment.	Fluorometholone	8-23	interleukin 1 beta	Mus musculus	78-86
21856425-6	2012	Together, these results suggest that endogenous IL-1beta possesses anticonvulsive properties that may be mediated by arachidonic acid metabolites derived from the catalytic action of COX-2.	Arachidonic Acid	117-133	interleukin 1 beta	Mus musculus	48-56
23236370-9	2012	Moreover, oroxylin A significantly attenuated LPS-induced late expression (20 hours after LPS challenge) of IL-1beta and IL-6.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	10-20	interleukin 1 beta	Mus musculus	108-116
23251498-8	2012	; once daily for 3 days) in the dorsal hippocampus were associated with a suppression of HI-induced increases in the expression of IL-1beta, TNF-alpha and IL-6.	hi	89-91	interleukin 1 beta	Mus musculus	131-139
23251531-13	2012	Isoflurane also impaired the cognitive functions of 10-week old C57BL/6J mice and increased IL-1beta in their hippocampi.	Isoflurane	0-10	interleukin 1 beta	Mus musculus	92-100
23056330-5	2012	We found that an rVSV vaccine induced local and systemic production of IL-1beta in vivo, and that accumulation of IL-1beta correlated with acute pathology after rVSV immunization.	rvsv	161-165	interleukin 1 beta	Mus musculus	114-122
23056330-5	2012	We found that an rVSV vaccine induced local and systemic production of IL-1beta in vivo, and that accumulation of IL-1beta correlated with acute pathology after rVSV immunization.	rvsv	17-21	interleukin 1 beta	Mus musculus	71-79
22937108-5	2012	The expressions of kidney injury marker neutrophil gelatinase-associated lipocalin and pro-inflammatory cytokines interleukin-6, tumor necrosis factor-alpha and interleukin-1beta were suppressed by MES+HS treatment.	2-(N-morpholino)ethanesulfonic acid	198-201	interleukin 1 beta	Mus musculus	161-178
23028835-5	2012	Inhibitors of ROS production inhibited secretion of IL-1beta, but did not impair IL-18 secretion.	Reactive Oxygen Species	14-17	interleukin 1 beta	Mus musculus	52-60
22952890-8	2012	Resveratrol significantly attenuated the LPS-induced expression of nitric oxide (NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in RAW 264.7 cells.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	221-238
22952890-8	2012	Resveratrol significantly attenuated the LPS-induced expression of nitric oxide (NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in RAW 264.7 cells.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	240-248
22815821-5	2012	We observed that mice receiving both silica and LPS had significantly more total inflammatory cells, more whole lung lavage MCP-1, MIP-2, KC and IL-1beta, more evidence of oxidative stress and more total lung hydroxyproline than mice receiving either LPS alone, or silica alone.	Silicon Dioxide	37-43	interleukin 1 beta	Mus musculus	145-153
22844497-8	2012	However, macrophages from DeltaSTY-infected mice died by pro-inflammatory necrosis characterized by membrane permeabilization and caspase-1 mediated IL-1beta production, whereas macrophages from DeltaSTY/DeltaPopB infected mice died by apoptosis, which is characterized by annexin V positive staining of the cell membrane and caspase-3 activation.	deltasty	26-34	interleukin 1 beta	Mus musculus	149-157
22815977-5	2012	Similarly, brilliant blue G (BBG), a clinically non-toxic P2X7 inhibitor, inhibited IL-1beta expression, limited edemic development, and improved neurobehavioral outcomes after TBI.	coomassie Brilliant Blue	11-27	interleukin 1 beta	Mus musculus	84-92
22815977-5	2012	Similarly, brilliant blue G (BBG), a clinically non-toxic P2X7 inhibitor, inhibited IL-1beta expression, limited edemic development, and improved neurobehavioral outcomes after TBI.	coomassie Brilliant Blue	29-32	interleukin 1 beta	Mus musculus	84-92
22720096-3	2012	In the present study, we show that a novel chromone derivative, DCO-6, significantly reduced lipopolysaccharide (LPS)-induced production of nitric oxide, IL-1beta and IL-6, decreased the levels of iNOS, IL-1beta and IL-6 mRNA expression in both RAW264.7 cells and mouse primary peritoneal macrophages, and inhibited LPS-induced activation of p38 MAPK but not of JNK, ERK.	Chromones	43-51	interleukin 1 beta	Mus musculus	154-162
22720096-3	2012	In the present study, we show that a novel chromone derivative, DCO-6, significantly reduced lipopolysaccharide (LPS)-induced production of nitric oxide, IL-1beta and IL-6, decreased the levels of iNOS, IL-1beta and IL-6 mRNA expression in both RAW264.7 cells and mouse primary peritoneal macrophages, and inhibited LPS-induced activation of p38 MAPK but not of JNK, ERK.	Chromones	43-51	interleukin 1 beta	Mus musculus	203-211
22615967-8	2012	CONCLUSION/SIGNIFICANCE: Our study suggested that Tregs could promote Th17 cells differentiation by regulating TGF-beta1 and IL-1beta in silica induced lung fibrosis of mice, which further the understanding of the progress of silicosis and provide a new insight in the regulatory mechanism of Th17 by Tregs in lung inflammation.	Silicon Dioxide	137-143	interleukin 1 beta	Mus musculus	125-133
22720096-3	2012	In the present study, we show that a novel chromone derivative, DCO-6, significantly reduced lipopolysaccharide (LPS)-induced production of nitric oxide, IL-1beta and IL-6, decreased the levels of iNOS, IL-1beta and IL-6 mRNA expression in both RAW264.7 cells and mouse primary peritoneal macrophages, and inhibited LPS-induced activation of p38 MAPK but not of JNK, ERK.	5,7-dihydroxy-3-(3-oxo-3-phenylprop-1-en-1-yl)-4H-chromen-4-one	64-69	interleukin 1 beta	Mus musculus	154-162
22720096-3	2012	In the present study, we show that a novel chromone derivative, DCO-6, significantly reduced lipopolysaccharide (LPS)-induced production of nitric oxide, IL-1beta and IL-6, decreased the levels of iNOS, IL-1beta and IL-6 mRNA expression in both RAW264.7 cells and mouse primary peritoneal macrophages, and inhibited LPS-induced activation of p38 MAPK but not of JNK, ERK.	5,7-dihydroxy-3-(3-oxo-3-phenylprop-1-en-1-yl)-4H-chromen-4-one	64-69	interleukin 1 beta	Mus musculus	203-211
22734421-9	2012	CONCLUSION: Saponin from Tupistra chinensis showed beneficial effect on the prevention of mice from lipopolysaccharides-induced death, in which down regulation of IL-1beta and TNF-alpha expression might be involved.	Saponins	12-19	interleukin 1 beta	Mus musculus	163-171
22427838-4	2012	Using an adriamycin(ADM)-based model of FSGS, we found that BALB/c mice presented albuminuria and glomerular degeneration in association with a Th2-like pro-fibrogenic profile; these mice also expressed a combination of inflammatory cytokines, such as IL-4, IL-1alpha, IL-1beta, IL-17, TNF-alpha, and chemokines, such as RANTES and eotaxin.	Doxorubicin	20-23	interleukin 1 beta	Mus musculus	269-277
22363816-8	2012	Resveratrol significantly attenuated the LPS-induced expression of NO, PGE2, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and nuclear factor-kappaB (NF-kappaB) in BV-2 cells.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	184-201
22363816-8	2012	Resveratrol significantly attenuated the LPS-induced expression of NO, PGE2, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and nuclear factor-kappaB (NF-kappaB) in BV-2 cells.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	203-211
22654663-8	2012	Chitohexaose inhibited LPS induced production of inflammatory molecules TNF-alpha, IL-1beta and IL-6 by macropahges in vitro and in vivo in mice.	chitohexaose	0-12	interleukin 1 beta	Mus musculus	83-91
22438931-4	2012	METHODS AND RESULTS: We developed a model of IL-1beta-induced left ventricular (LV) dysfunction in healthy mice that exhibited a 32% reduction in LV fractional shortening (P&lt;0.001) and a 76% reduction in isoproterenol response (P&lt;0.01) at 4 hours following a single dose of IL-1beta 3 mcg/kg.	Isoproterenol	207-220	interleukin 1 beta	Mus musculus	45-53
22185406-13	2011	The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40).	Quercetin	73-82	interleukin 1 beta	Mus musculus	189-197
22114936-5	2011	In LPS-stimulated peritoneal macrophages, the oleuropein metabolite, hydroxytyrosol, was shown to inhibit NO production, iNOS expression, NF-kappaB p65 subunit translocation, mRNA expression, and the release of IL-1beta, IL-6, and TNF-alpha.	3,4-dihydroxyphenylethanol	69-83	interleukin 1 beta	Mus musculus	211-219
22185406-13	2011	The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40).	tocotrienol, delta	86-103	interleukin 1 beta	Mus musculus	189-197
22210038-7	2011	LP potently inhibited histamine-induced cytokine production: it (1 x 10(10) CFU per mouse) inhibited IL-4, IL-1beta, and TNF-alpha expression by 88.9%, 88.6%, and 98.9%, respectively.	leucylproline	0-2	interleukin 1 beta	Mus musculus	107-115
22136135-9	2011	Co-stimulation of microglia with LPS and adenosine triphosphate also resulted in increased phagocytosis, an effect inhibited by an interleukin-1 receptor antagonist, suggesting involvement of IL-1beta signaling.	Adenosine Triphosphate	41-63	interleukin 1 beta	Mus musculus	192-200
21656169-5	2011	We also observed the inhibitory effects of I-RTX on UV-induced mRNA expression of the pro-inflammatory cytokines, interleukin (IL)-1beta, IL-2, IL-4, and tumor necrosis factor-alpha.	iodoresiniferatoxin	43-48	interleukin 1 beta	Mus musculus	114-136
22064046-6	2011	However, adult mice prenatally exposed to quercetin had significant increase iron storage in the liver, by upregulating iron-associated cytokine expression (hepcidin, IL-1beta, IL-6 and IL-10).	Quercetin	42-51	interleukin 1 beta	Mus musculus	167-175
22064046-6	2011	However, adult mice prenatally exposed to quercetin had significant increase iron storage in the liver, by upregulating iron-associated cytokine expression (hepcidin, IL-1beta, IL-6 and IL-10).	Iron	120-124	interleukin 1 beta	Mus musculus	167-175
22210038-7	2011	LP potently inhibited histamine-induced cytokine production: it (1 x 10(10) CFU per mouse) inhibited IL-4, IL-1beta, and TNF-alpha expression by 88.9%, 88.6%, and 98.9%, respectively.	Histamine	22-31	interleukin 1 beta	Mus musculus	107-115
22210038-10	2011	Based on these findings, LP may improve allergic diseases, such as anaphylaxis, atopic dermatitis, rhinitis, and pruritus by inhibiting the expression of IgE-switching cytokine IL-4 and proinflammatory cytokines IL-1beta and TNF-alpha via NF-kappaB and AP-1 signaling pathways.	leucylproline	25-27	interleukin 1 beta	Mus musculus	212-220
22217712-10	2011	Ascorbate supplementation of gulo KO mice resulted in profoundly decreased serum inflammatory cytokine IL-6 (90% decrease, p = 0.04) and IL-1beta (62% decrease) compared to the levels in gulo KO mice deprived of ascorbate.	Ascorbic Acid	0-9	interleukin 1 beta	Mus musculus	137-145
21993466-9	2011	Treatment with 0.1% EGCG was associated with a significant decrease in the corneal expression of interleukin-1beta (P = 0.029) and chemokine ligand 2 (P = 0.001) compared with the vehicle and in VEGF-A and VEGF-D levels compared with the untreated group (P = 0.007 and P = 0.048, respectively).	epigallocatechin gallate	20-24	interleukin 1 beta	Mus musculus	97-114
21899910-3	2011	SDEE inhibits IL-1beta/IFN-gamma-stimulated NO, TNF-alpha release, and iNOS expression.	sdee	0-4	interleukin 1 beta	Mus musculus	14-22
21899910-4	2011	Furthermore, SDEE suppressed the IL-1beta/IFN-gamma- or STZ-induced p65 expression of NF-kappaB, which is associated with inhibition of IkappaB-alpha degradation.	sdee	13-17	interleukin 1 beta	Mus musculus	33-41
21996541-7	2011	Furthermore, the production of pro inflammatory cytokines TNF-alpha, interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) was significantly reduced in K68-administered group.	(4,5,6,7-Tetrabromo-1h-Benzimidazol-1-Yl)acetic Acid	153-156	interleukin 1 beta	Mus musculus	69-86
21826694-9	2011	Expression of liver proinflammatory cytokines tumor necrosis factor alpha, interleukin (IL)-1beta, IL-6, KC/IL-8, intercellular adhesion molecule 1, and cluster of differentiation 68 was induced in alcohol-fed WT, but inhibited in MCP-1KO, mice independent of nuclear factor kappa light-chain enhancer of activated B cell activation in KCs.	Alcohols	198-205	interleukin 1 beta	Mus musculus	75-97
22015602-9	2011	In addition, hydrogen decreased malonaldehyde and nitrotyrosine content, inhibited myeloperoxidase and maintained superoxide dismutase activity in lung tissues and associated with a decrease in the expression of TNF-alpha, IL-1beta, IL-6 and total protein concentrations in the BALF.	Hydrogen	13-21	interleukin 1 beta	Mus musculus	223-231
21996541-7	2011	Furthermore, the production of pro inflammatory cytokines TNF-alpha, interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) was significantly reduced in K68-administered group.	(4,5,6,7-Tetrabromo-1h-Benzimidazol-1-Yl)acetic Acid	153-156	interleukin 1 beta	Mus musculus	88-96
21826708-4	2011	Similarly, ailanthoidol inhibited the production of inflammatory cytokines induced by LPS in RAW264.7 cells, including interleukin (IL)-1beta and IL-6.	ailanthoidol	11-23	interleukin 1 beta	Mus musculus	119-141
22019446-4	2011	Salidroside significantly attenuated TNF-alpha, IL-1beta and IL-6 productions in serum from mice challenged with LPS, and consistent with the results in vitro.	rhodioloside	0-11	interleukin 1 beta	Mus musculus	48-56
21475978-5	2011	RESULTS: We found that (1) locally delivered miRNA inhibited titanium alloy particle-induced tissue inflammation, including the diminished pouch membrane thickness and reduced inflammatory cellular infiltration and that (2) locally delivered miRNA inhibited expressions of the inflammatory cytokines VEGF, tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and receptor activator of nuclear factor kappa B ligand (RANKL).	Titanium	61-75	interleukin 1 beta	Mus musculus	348-365
21475978-5	2011	RESULTS: We found that (1) locally delivered miRNA inhibited titanium alloy particle-induced tissue inflammation, including the diminished pouch membrane thickness and reduced inflammatory cellular infiltration and that (2) locally delivered miRNA inhibited expressions of the inflammatory cytokines VEGF, tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and receptor activator of nuclear factor kappa B ligand (RANKL).	Titanium	61-75	interleukin 1 beta	Mus musculus	367-375
21809372-5	2011	Pelubiprofen potently diminished PGE(2) productions through inhibition of COX enzyme activity (IC(50) values for COX-1 and COX-2 are 10.66 +- 0.99 and 2.88 +- 1.01 microM, respectively), but also reduced the expressions of COX-2, inducible nitric oxide (iNOS), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 at transcriptional level in LPS-induced RAW 264.7 cells.	pelubiprofen	0-12	interleukin 1 beta	Mus musculus	302-319
21809372-5	2011	Pelubiprofen potently diminished PGE(2) productions through inhibition of COX enzyme activity (IC(50) values for COX-1 and COX-2 are 10.66 +- 0.99 and 2.88 +- 1.01 microM, respectively), but also reduced the expressions of COX-2, inducible nitric oxide (iNOS), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 at transcriptional level in LPS-induced RAW 264.7 cells.	pelubiprofen	0-12	interleukin 1 beta	Mus musculus	321-329
21809375-5	2011	In addition, roxatidine reduced the productions and expressions of VEGF-1 and pro-inflammatory cytokines, including those of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6).	roxatidine acetate	13-23	interleukin 1 beta	Mus musculus	166-183
21809375-5	2011	In addition, roxatidine reduced the productions and expressions of VEGF-1 and pro-inflammatory cytokines, including those of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6).	roxatidine acetate	13-23	interleukin 1 beta	Mus musculus	185-193
21864548-2	2011	It has been shown that interleukin-1beta (IL-1beta) contributes to the cognitive impairment of mice after surgery and isoflurane anesthesia.	Isoflurane	118-128	interleukin 1 beta	Mus musculus	23-40
21703208-6	2011	RESULTS: DSS treatment caused inflammation and proinflammatory gene expression (IL-1beta, IL-17, TNF) in the colon.	Dextran Sulfate	9-12	interleukin 1 beta	Mus musculus	80-88
21671006-0	2011	The role of IL-1beta in nicotine-induced immunosuppression and neuroimmune communication.	Nicotine	24-32	interleukin 1 beta	Mus musculus	12-20
21671006-5	2011	To examine the relationship between NT, IL-1beta, and immunosuppression, we hypothesized that NT induces IL-1beta in the brain, and its constant presence produces immunological "tolerance".	Nicotine	94-96	interleukin 1 beta	Mus musculus	40-48
21671006-5	2011	To examine the relationship between NT, IL-1beta, and immunosuppression, we hypothesized that NT induces IL-1beta in the brain, and its constant presence produces immunological "tolerance".	Nicotine	94-96	interleukin 1 beta	Mus musculus	105-113
21671006-9	2011	Moreover, the immunosuppressive effects of NT might be at least partly mediated through its effects on the brain IL-1beta.	Nicotine	43-45	interleukin 1 beta	Mus musculus	113-121
21962807-9	2011	Furthermore, pretreatment of mice with fasudil inhibited LPS-induced increasing of TNF-alpha, IL-1beta mRNA expression (3 and 6 h) and AP-1/DNA binding activity (3 h) in blood cells.	fasudil	39-46	interleukin 1 beta	Mus musculus	94-102
22024414-9	2011	The administration of SR144528 declined interferon-gamma, IL-17, IL-4, IL-10, IL-1beta, IL-6 and tumor necrosis factor-alpha, but increased CX3CL1 in brain and/or spinal cord.	SR 144528	22-30	interleukin 1 beta	Mus musculus	78-86
21864548-2	2011	It has been shown that interleukin-1beta (IL-1beta) contributes to the cognitive impairment of mice after surgery and isoflurane anesthesia.	Isoflurane	118-128	interleukin 1 beta	Mus musculus	42-50
21970803-4	2011	MPTP treatment enhanced the release of interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, IL-4 and IL-10 (P &lt; 0.05).	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	0-4	interleukin 1 beta	Mus musculus	39-61
22075574-6	2011	Additionally, it was determined that ethyl caffeate (6) down-regulated mRNA expressions of iNOS, IL-1beta, and IL-10 in the LPS-treatment of RAW264.7 cells via a suppressed NF-kB pathway.	ethyl caffeate	37-51	interleukin 1 beta	Mus musculus	97-105
21917879-8	2011	RESULTS: Ketanserin significantly increased survival time and decreased serum levels of tumor necrosis factor alpha and interleukin (IL) 1beta in mice with endotoxic shock.	Ketanserin	9-19	interleukin 1 beta	Mus musculus	120-142
21925895-6	2011	In group treated with 2.5mg PF/cm(2) before UV-B irradiation BM extract inhibited UV-B-induced sunburn cells, restored the superoxide dismutase (MnSOD) activity, increased insignificantly CAT and GPx activities and reduced IL-1beta level.	pyrazofurin	28-30	interleukin 1 beta	Mus musculus	223-231
22072681-7	2011	The rescue of tissue by TRAM-34 treatment was preceded by reduced expression of the proinflammatory mediators, tumor necrosis factor-alpha and interleukin-1beta in spinal cord tissue at 12 h after injury, and reduced expression of inducible nitric oxide synthase at 7 d after SCI.	TRAM 34	24-31	interleukin 1 beta	Mus musculus	143-160
21987296-7	2011	DSS-enhanced thrombus formation was evaluated in wildtype (WT) mice treated with an anti-TNF-alpha antibody (+-an anti-IL-1beta antibody) and in TNF-alpha receptor-deficient (TNFr(-/-) ) mice.	dss	0-3	interleukin 1 beta	Mus musculus	119-127
21862582-4	2011	We prepared highly purified chitosan and chitin and examined the capacity of these glycans to stimulate murine macrophages to release the inflammasome-associated cytokine IL-1beta.	Polysaccharides	83-90	interleukin 1 beta	Mus musculus	171-179
21622588-5	2011	In CS-exposed mice, pulmonary inflammation was dependent on IL-1RI and could be significantly attenuated by neutralising IL-1alpha or IL-1beta.	Cesium	3-5	interleukin 1 beta	Mus musculus	134-142
21622588-8	2011	These results suggest that not only IL-1beta but also IL-1alpha should be considered as an important mediator in CS-induced inflammation and COPD.	Cesium	113-115	interleukin 1 beta	Mus musculus	36-44
21841536-13	2011	2-Methoxyestradiol significantly reduced IL-1beta, IL-6, TNF-alpha, and NO levels in septic mice as well as in LPS-stimulated peritoneal macrophages.	2-Methoxyestradiol	0-18	interleukin 1 beta	Mus musculus	41-49
22002608-6	2011	Interestingly, Casp11(-/-) macrophages secreted IL-1beta normally in response to ATP and monosodium urate, indicating that caspase-11 is engaged by a non-canonical inflammasome.	Adenosine Triphosphate	81-84	interleukin 1 beta	Mus musculus	48-56
22002608-6	2011	Interestingly, Casp11(-/-) macrophages secreted IL-1beta normally in response to ATP and monosodium urate, indicating that caspase-11 is engaged by a non-canonical inflammasome.	Uric Acid	89-105	interleukin 1 beta	Mus musculus	48-56
21862582-9	2011	Inhibition of phagocytosis with cytochalasin D abolished the IL-1beta stimulatory activity of chitosan, offering an explanation for why the largest particles were nearly devoid of activity.	Cytochalasin D	32-46	interleukin 1 beta	Mus musculus	61-69
21969559-7	2011	Indeed, upon manipulation of the melanoma microenvironment with the phosphodiesterase-5 inhibitor sildenafil, we observed reduced levels of numerous inflammatory mediators (e.g., IL-1beta, IL-6, VEGF, S100A9) in association with decreased MDSC amounts and immunosuppressive function, indicating an antiinflammatory effect of sildenafil.	Sildenafil Citrate	98-108	interleukin 1 beta	Mus musculus	179-187
21951854-5	2011	A detailed study of the methylation of CpGs sites using bisulfite-sequencing PCR and 5-methylcytosine immunoprecipitation showed that hypoxia induced DNA methylation in both the enhancer and promoter regions of MCP-1in IL-1beta-treated cells.	cytidylyl-3'-5'-guanosine	39-43	interleukin 1 beta	Mus musculus	219-227
21788310-8	2011	In vitro, lidocaine down-regulated IFN-gamma-induced gene induction of inducible oxide synthase and interleukin-1beta.	Lidocaine	10-19	interleukin 1 beta	Mus musculus	100-117
21835925-3	2011	Here, we report that lipopolysaccharide (LPS) and Pam(3)CysSerLys(4) exerted more profound effects on release of the proinflammatory cytokines, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha (TNFalpha), in glia prepared from CD200(-/-) mice compared with wild type mice.	pam	50-53	interleukin 1 beta	Mus musculus	144-166
21835925-3	2011	Here, we report that lipopolysaccharide (LPS) and Pam(3)CysSerLys(4) exerted more profound effects on release of the proinflammatory cytokines, interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha (TNFalpha), in glia prepared from CD200(-/-) mice compared with wild type mice.	(3)cysserlys	53-65	interleukin 1 beta	Mus musculus	144-166
21778460-7	2011	In addition, TMMC inhibited pancreatic acinar cell death and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 by inhibiting NF-kappaB and extracellular signal-regulated protein kinase 1/2 (ERK1/2) activation.	2',4',6'-tris(methoxymethoxy) chalcone	13-17	interleukin 1 beta	Mus musculus	110-132
22000485-4	2011	We found both IL-1beta and interleukin-1 receptor antagonist (IL-1Ra) concentrations in serum were highly induced after DOX treatment, associated with increased IL-1RI expression in cardiac tissues.	Doxorubicin	120-123	interleukin 1 beta	Mus musculus	14-22
21710212-5	2011	The immunomodulatory activity of the c-di-GMP preparation was confirmed by its potentiating effect on the lipopolysaccharide-induced interleukin 1beta, tumor necrosis factor alpha, and interleukin 6 messenger RNA expression in J774A.1 mouse macrophages.	bis(3',5')-cyclic diguanylic acid	37-45	interleukin 1 beta	Mus musculus	133-179
22000485-6	2011	Histology score of cardiac tissues showed obvious cardiac damage after DOX treatment, while assessment with the Spearman rank correlation coefficient showed that histology score was closely correlated with IL-1beta and IL-1Ra concentrations in serum and IL-1RI expression in cardiac tissue.	Doxorubicin	71-74	interleukin 1 beta	Mus musculus	206-214
21449918-9	2011	KEY RESULTS: Kaempferol significantly attenuated LPS-induced NO, PGE(2) , TNF-alpha, IL-1beta and ROS production and phagocytosis in a concentration-dependent manner.	kaempferol	13-23	interleukin 1 beta	Mus musculus	85-93
21645546-7	2011	Therefore, these results suggest that the anti-inflammatory effects of Schisandrin on P. gingivalis LPS-stimulated RAW 264.7 cells may be due to a reduction of NF-kappaB activity and induction of the expression of HO-1, leading to TNF-alpha, IL-1beta, and IL-6 down-regulation.	schizandrin	71-82	interleukin 1 beta	Mus musculus	242-250
21905822-5	2011	Treatment with thujone downregulated the production of proinflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, and granulocyte-monocyte colony-stimulating factor.	beta-thujone	15-22	interleukin 1 beta	Mus musculus	118-140
21689743-5	2011	In addition, we found that Alloxan induces AMPK differently from IL1beta, as Alloxan acts mainly through CaMKII while IL1beta acts through LKB1 phosphorylation.	Alloxan	27-34	interleukin 1 beta	Mus musculus	118-125
21737615-1	2011	Tobacco smoke (TS) interacts with interleukin-1beta (IL-1beta) to modulate generation of reactive oxygen species (ROS) and expression of cyclooxygenase-2.	Reactive Oxygen Species	89-112	interleukin 1 beta	Mus musculus	34-51
21737615-1	2011	Tobacco smoke (TS) interacts with interleukin-1beta (IL-1beta) to modulate generation of reactive oxygen species (ROS) and expression of cyclooxygenase-2.	Reactive Oxygen Species	89-112	interleukin 1 beta	Mus musculus	53-61
21737615-1	2011	Tobacco smoke (TS) interacts with interleukin-1beta (IL-1beta) to modulate generation of reactive oxygen species (ROS) and expression of cyclooxygenase-2.	Reactive Oxygen Species	114-117	interleukin 1 beta	Mus musculus	34-51
21737615-1	2011	Tobacco smoke (TS) interacts with interleukin-1beta (IL-1beta) to modulate generation of reactive oxygen species (ROS) and expression of cyclooxygenase-2.	Reactive Oxygen Species	114-117	interleukin 1 beta	Mus musculus	53-61
21737615-3	2011	TS (EC(50) ~5 puffs/L) interacting with IL-1beta (2 mug/L) up-regulates PGE(2) production and mPGES-1 expression, reaching a plateau at 4-6 h, but down-regulates prostacyclin (PGI(2)) release by increasing IL-1beta-mediated PGIS tyrosine nitration.	Prostaglandins E	72-75	interleukin 1 beta	Mus musculus	40-48
21737615-3	2011	TS (EC(50) ~5 puffs/L) interacting with IL-1beta (2 mug/L) up-regulates PGE(2) production and mPGES-1 expression, reaching a plateau at 4-6 h, but down-regulates prostacyclin (PGI(2)) release by increasing IL-1beta-mediated PGIS tyrosine nitration.	Epoprostenol	162-174	interleukin 1 beta	Mus musculus	40-48
22128263-6	2011	Pretreatment of cyclosporine A blocked the increases of RCAN1.4 stimulated by IL-1beta or AGE-BSA, suggesting that activation of CaN is required for the RCAN1.4 induction.	Cyclosporine	16-30	interleukin 1 beta	Mus musculus	78-86
21645546-3	2011	First, Schisandrin inhibited LPS-induced pro-inflammatory cytokines, including TNF-alpha, IL-1beta, and IL-6.	schizandrin	7-18	interleukin 1 beta	Mus musculus	90-98
21756897-4	2011	Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterised by: infiltration of neutrophils in lung tissues and subsequent lipid peroxidation, increased production of nitric oxide (NO), cytokines such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) and increased expression of intercellular adhesion molecule (ICAM-1) and platelet-adhesion molecule (P-selectin).	Carrageenan	13-24	interleukin 1 beta	Mus musculus	300-317
21756897-4	2011	Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterised by: infiltration of neutrophils in lung tissues and subsequent lipid peroxidation, increased production of nitric oxide (NO), cytokines such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) and increased expression of intercellular adhesion molecule (ICAM-1) and platelet-adhesion molecule (P-selectin).	Carrageenan	13-24	interleukin 1 beta	Mus musculus	319-327
20686830-2	2011	Kakkalide and irisolidone down-regulated the gene expression of cytokines [tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta)] and cyclooxygenase-2 (COX-2) and the production of pro-inflammatory cytokines, TNF-alpha and IL-1beta, and inflammatory mediators, NO and prostaglandin E(2) (PGE(2)), in LPS-stimulated peritoneal macrophages.	kakkalide	0-9	interleukin 1 beta	Mus musculus	119-137
20686830-2	2011	Kakkalide and irisolidone down-regulated the gene expression of cytokines [tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta)] and cyclooxygenase-2 (COX-2) and the production of pro-inflammatory cytokines, TNF-alpha and IL-1beta, and inflammatory mediators, NO and prostaglandin E(2) (PGE(2)), in LPS-stimulated peritoneal macrophages.	kakkalide	0-9	interleukin 1 beta	Mus musculus	139-147
20686830-2	2011	Kakkalide and irisolidone down-regulated the gene expression of cytokines [tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta)] and cyclooxygenase-2 (COX-2) and the production of pro-inflammatory cytokines, TNF-alpha and IL-1beta, and inflammatory mediators, NO and prostaglandin E(2) (PGE(2)), in LPS-stimulated peritoneal macrophages.	kakkalide	0-9	interleukin 1 beta	Mus musculus	243-251
20686830-2	2011	Kakkalide and irisolidone down-regulated the gene expression of cytokines [tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta)] and cyclooxygenase-2 (COX-2) and the production of pro-inflammatory cytokines, TNF-alpha and IL-1beta, and inflammatory mediators, NO and prostaglandin E(2) (PGE(2)), in LPS-stimulated peritoneal macrophages.	irisolidone	14-25	interleukin 1 beta	Mus musculus	119-137
20686830-2	2011	Kakkalide and irisolidone down-regulated the gene expression of cytokines [tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta)] and cyclooxygenase-2 (COX-2) and the production of pro-inflammatory cytokines, TNF-alpha and IL-1beta, and inflammatory mediators, NO and prostaglandin E(2) (PGE(2)), in LPS-stimulated peritoneal macrophages.	irisolidone	14-25	interleukin 1 beta	Mus musculus	139-147
20686830-2	2011	Kakkalide and irisolidone down-regulated the gene expression of cytokines [tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta)] and cyclooxygenase-2 (COX-2) and the production of pro-inflammatory cytokines, TNF-alpha and IL-1beta, and inflammatory mediators, NO and prostaglandin E(2) (PGE(2)), in LPS-stimulated peritoneal macrophages.	irisolidone	14-25	interleukin 1 beta	Mus musculus	243-251
21730010-8	2011	Protein levels of IL-1beta, macrophage inflammatory protein-2, intercellular adhesion molecule-1, and cyclooxygenase-2 were reduced by IPT administration in the nasal mucosa of the OVA-sensitized mice.	imperatorin	135-138	interleukin 1 beta	Mus musculus	18-26
21730010-12	2011	In addition, IPT inhibited caspase-1 activity and IL-1beta production in IgE-stimulated bone marrow-derived mast cells.	imperatorin	13-16	interleukin 1 beta	Mus musculus	50-58
21763473-2	2011	At day 1, BMDMC significantly reduced mortality, as well as caspase-3, interleukin (IL)-6 and IL-1beta, vascular endothelial growth factor, platelet-derived growth factor, hepatocyte growth factor, and transforming growth factor-beta, but increased IL-10 mRNA expression in lung tissue in septic mice contributing to endothelium and epithelium alveolar repair and improvement of lung mechanics.	bmdmc	10-15	interleukin 1 beta	Mus musculus	94-102
21844393-8	2011	In conclusion, these data show that the DEP-induced pulmonary inflammation acts through the IL-1beta/IL-1RI axis.	dep	40-43	interleukin 1 beta	Mus musculus	92-100
21798271-8	2011	Anisodamine significantly decreased TNF-alpha and IL-1beta production in LPS-treated RAW264.7 cells and C57BL/6 mice.	anisodamine	0-11	interleukin 1 beta	Mus musculus	50-58
21498084-7	2011	WT+STZ mice exhibited significantly increased levels of serum and macrophage IL-1beta, IL-6, KC/IL-8, IP-10, MCP-1, IFN beta and TNF-alpha compared to WT mice and this was significantly attenuated in TLR4(-/-) +STZ mice (P&lt;0.01).	Streptozocin	3-6	interleukin 1 beta	Mus musculus	77-85
21667041-1	2011	The inhibition of mevalonate pathway by the aminobisphosphonate alendronate (ALD) has been previously associated with an augmented lipopolysaccharide-induced interleukin-1beta (IL-1beta) secretion in monocytes, as demonstrated in an auto-inflammatory disease known as mevalonate kinase deficiency (MKD).	Mevalonic Acid	18-28	interleukin 1 beta	Mus musculus	158-175
21667041-1	2011	The inhibition of mevalonate pathway by the aminobisphosphonate alendronate (ALD) has been previously associated with an augmented lipopolysaccharide-induced interleukin-1beta (IL-1beta) secretion in monocytes, as demonstrated in an auto-inflammatory disease known as mevalonate kinase deficiency (MKD).	Mevalonic Acid	18-28	interleukin 1 beta	Mus musculus	177-185
21667041-1	2011	The inhibition of mevalonate pathway by the aminobisphosphonate alendronate (ALD) has been previously associated with an augmented lipopolysaccharide-induced interleukin-1beta (IL-1beta) secretion in monocytes, as demonstrated in an auto-inflammatory disease known as mevalonate kinase deficiency (MKD).	aminobisphosphonate	44-63	interleukin 1 beta	Mus musculus	158-175
21667041-1	2011	The inhibition of mevalonate pathway by the aminobisphosphonate alendronate (ALD) has been previously associated with an augmented lipopolysaccharide-induced interleukin-1beta (IL-1beta) secretion in monocytes, as demonstrated in an auto-inflammatory disease known as mevalonate kinase deficiency (MKD).	aminobisphosphonate	44-63	interleukin 1 beta	Mus musculus	177-185
21667041-1	2011	The inhibition of mevalonate pathway by the aminobisphosphonate alendronate (ALD) has been previously associated with an augmented lipopolysaccharide-induced interleukin-1beta (IL-1beta) secretion in monocytes, as demonstrated in an auto-inflammatory disease known as mevalonate kinase deficiency (MKD).	Alendronate	64-75	interleukin 1 beta	Mus musculus	158-175
21667041-1	2011	The inhibition of mevalonate pathway by the aminobisphosphonate alendronate (ALD) has been previously associated with an augmented lipopolysaccharide-induced interleukin-1beta (IL-1beta) secretion in monocytes, as demonstrated in an auto-inflammatory disease known as mevalonate kinase deficiency (MKD).	Alendronate	64-75	interleukin 1 beta	Mus musculus	177-185
21601209-7	2011	In human CRP transgenic mice (quercetin plasma concentration: 12.9 +- 1.3 muM), quercetin quenched IL1beta-induced CRP expression, as did sodium salicylate.	Quercetin	80-89	interleukin 1 beta	Mus musculus	99-106
21153821-9	2011	RESULTS: 5-FU treatment decreased the duodenal villus height/crypt depth ratio, increased MPO activity, and increased the concentration of TNF-alpha, IL-1beta and KC in comparison with saline-treated animals.	Fluorouracil	9-13	interleukin 1 beta	Mus musculus	150-158
21514967-8	2011	The expression of pro-inflammatory biomarkers including inducible nitric oxide synthase (iNOS), interleukin-1beta (IL-1beta), and tumor necrosis factor (TNF-alpha) was suppressed by the treatment of thio-Cl-IB-MECA in the protein and mRNA levels in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells.	thio-Cl-IB-MECA	199-214	interleukin 1 beta	Mus musculus	96-113
21247369-6	2011	In addition, vernolide-A significantly down-regulated the serum levels of proinflammatory cytokines such as IL-1beta, IL-6, tumor necrosis factor-alpha (TNF-alpha), and granulocyte-macrophage colony-stimulating factor (GM-CSF) during metastasis.	vernolide-A	13-24	interleukin 1 beta	Mus musculus	108-116
21753131-7	2011	IL-1beta stimulated the production of PGE(2), IL-6, IL-8 and monocyte chemotactic protein-1 very potently, but not that of nitric oxide and tumor necrosis factor-alpha.	Prostaglandins E	38-41	interleukin 1 beta	Mus musculus	0-8
21514967-8	2011	The expression of pro-inflammatory biomarkers including inducible nitric oxide synthase (iNOS), interleukin-1beta (IL-1beta), and tumor necrosis factor (TNF-alpha) was suppressed by the treatment of thio-Cl-IB-MECA in the protein and mRNA levels in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells.	thio-Cl-IB-MECA	199-214	interleukin 1 beta	Mus musculus	115-123
21575743-5	2011	Dehydrocorydaline also prevented increased concentrations of IL-1beta and IL-6 in culture media of LPS-stimulated macrophages.	dehydrocorydalin	0-17	interleukin 1 beta	Mus musculus	61-69
21496499-5	2011	The treatment with tetrandrine resulted in downregulation of phospho NF-kappaB p65 expression and strikingly reduced the production of IL-1beta and TNF-alpha.	tetrandrine	19-30	interleukin 1 beta	Mus musculus	135-143
21690238-9	2011	In vitro studies demonstrated that GBS sialic acids participate in the suppression of murine polymorphonuclear leukocyte (PMN) bactericidal activities, in addition to reducing levels of IL-1alpha, tumor necrosis factor alpha, IL-1beta, MIP-1alpha, and KC produced by PMNs.	Sialic Acids	39-51	interleukin 1 beta	Mus musculus	226-234
21528358-6	2011	RESULTS: Folic acid inhibited LPS-induced production of NO, TNF-alpha and IL-1beta with decreased mRNAs of inducible nitric oxide synthase (iNOS), TNF-alpha and IL-1beta.	Folic Acid	9-19	interleukin 1 beta	Mus musculus	74-82
21528358-6	2011	RESULTS: Folic acid inhibited LPS-induced production of NO, TNF-alpha and IL-1beta with decreased mRNAs of inducible nitric oxide synthase (iNOS), TNF-alpha and IL-1beta.	Folic Acid	9-19	interleukin 1 beta	Mus musculus	161-169
21667204-6	2011	RESULTS: MHNA significantly inhibited the release of NO, IL-1beta and IL-6 as well as the protein expression of iNOS and COX-2 in LPS-stimulated macrophages.	mhna	9-13	interleukin 1 beta	Mus musculus	57-65
21843370-11	2011	Furthermore, GTS-associated recovery from LPS-induced depression-like behavior was paralleled with reduced mRNA levels for IL-1beta, IL-6, TNF-alpha, and IDO in hippocampus.	Glutathionesulfonic acid	13-16	interleukin 1 beta	Mus musculus	123-131
21782918-6	2011	RESULTS: As to IL-1beta, only citral inhibited its release, exerting an efficient action before LPS challenge.	citral	30-36	interleukin 1 beta	Mus musculus	15-23
20680516-0	2011	Xenon enhances LPS-induced IL-1beta expression in microglia via the extracellular signal-regulated kinase 1/2 pathway.	Xenon	0-5	interleukin 1 beta	Mus musculus	27-35
20680516-6	2011	Xenon significantly enhanced LPS-mediated IL-1beta expression.	Xenon	0-5	interleukin 1 beta	Mus musculus	42-50
21998608-5	2011	Administration of high-dose TBE (400 mg/kg) increased the interleukin-1beta and interleukin-6 levels in the peritoneal cavity over the short term (&lt;1 day) compared with sham controls and low-dose TBE (200 mg/kg) groups.	tbe	28-31	interleukin 1 beta	Mus musculus	58-75
20680516-9	2011	Xenon decreased cellular phosphatase activity in microglia by 20% and inhibited dephosphorylation of ERK 1/2 up to 1 h. The blocking of ERK 1/2 reduced IL-1beta expression in xenon and LPS-treated cells to a level obtained by LPS alone.	Xenon	0-5	interleukin 1 beta	Mus musculus	152-160
20680516-9	2011	Xenon decreased cellular phosphatase activity in microglia by 20% and inhibited dephosphorylation of ERK 1/2 up to 1 h. The blocking of ERK 1/2 reduced IL-1beta expression in xenon and LPS-treated cells to a level obtained by LPS alone.	Xenon	175-180	interleukin 1 beta	Mus musculus	152-160
20680516-10	2011	In conclusion, xenon enhanced LPS-induced IL-1beta expression in microglia by activation of ERK 1/2 signalling.	Xenon	15-20	interleukin 1 beta	Mus musculus	42-50
21672630-6	2011	Furthermore, in slices from non-EAE mice, we found that genetic or pharmacological blockade of TRPV1 channels enhanced the synaptic effects of tumor necrosis factor alpha (TNF-alpha) on glutamate-mediated excitatory postsynaptic currents, and prevented the action of interleukin 1beta (IL-1beta) on GABAergic inhibitory postsynaptic currents.	Glutamic Acid	186-195	interleukin 1 beta	Mus musculus	267-284
21672630-6	2011	Furthermore, in slices from non-EAE mice, we found that genetic or pharmacological blockade of TRPV1 channels enhanced the synaptic effects of tumor necrosis factor alpha (TNF-alpha) on glutamate-mediated excitatory postsynaptic currents, and prevented the action of interleukin 1beta (IL-1beta) on GABAergic inhibitory postsynaptic currents.	Glutamic Acid	186-195	interleukin 1 beta	Mus musculus	286-294
21498061-8	2011	Moreover GTP and its bioactive components (catechin, epigallocatechin and epigallocatechin-3-gallate) assisted in decreasing the leukocytopenia seen after whole mice irradiation and significantly reduced the elevated serum inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6).	Guanosine Triphosphate	9-12	interleukin 1 beta	Mus musculus	258-266
21498061-8	2011	Moreover GTP and its bioactive components (catechin, epigallocatechin and epigallocatechin-3-gallate) assisted in decreasing the leukocytopenia seen after whole mice irradiation and significantly reduced the elevated serum inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6).	Catechin	43-51	interleukin 1 beta	Mus musculus	258-266
21498061-8	2011	Moreover GTP and its bioactive components (catechin, epigallocatechin and epigallocatechin-3-gallate) assisted in decreasing the leukocytopenia seen after whole mice irradiation and significantly reduced the elevated serum inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6).	epigallocatechin gallate	74-100	interleukin 1 beta	Mus musculus	258-266
21596115-5	2011	Further experiments with BV2 microglial cells showed the exposure to Fe(2)O(3) nanoparticles could induce cells proliferation, phagocytosis and generation of ROS and NO, but did not cause significant release of inflammatory factors, including IL-1beta, IL-6 and TNF-alpha.	fe(2)o(3)	69-78	interleukin 1 beta	Mus musculus	243-251
21501147-5	2011	KEY RESULTS: Exogenous and endogenous 2-AG-produced suppressions of NF-kappaB-p65 phosphorylation, COX-2 expression and excitatory synaptic transmission in response to pro-inflammatory interleukin-1beta (IL-1beta) and LPS were inhibited by GW9662, a selective PPARgamma antagonist, in hippocampal neurons in culture.	glyceryl 2-arachidonate	38-42	interleukin 1 beta	Mus musculus	185-202
21447380-0	2011	Naloxone-precipitated morphine withdrawal behavior and brain IL-1beta expression: comparison of different mouse strains.	Naloxone	0-8	interleukin 1 beta	Mus musculus	61-69
21447380-7	2011	Analysis of brain nuclei (medial prefrontal cortex, cortex, brain stem, hippocampus, and midbrain and diencephalon regions combined) revealed that, of inbred wild-type mice, there are significant main effects of morphine treatment on IL-1beta expression in the brain regions analyzed (p&lt;0.02 for all regions analyzed).	Morphine	212-220	interleukin 1 beta	Mus musculus	234-242
21501147-5	2011	KEY RESULTS: Exogenous and endogenous 2-AG-produced suppressions of NF-kappaB-p65 phosphorylation, COX-2 expression and excitatory synaptic transmission in response to pro-inflammatory interleukin-1beta (IL-1beta) and LPS were inhibited by GW9662, a selective PPARgamma antagonist, in hippocampal neurons in culture.	glyceryl 2-arachidonate	38-42	interleukin 1 beta	Mus musculus	204-212
21447380-8	2011	A significant increase in hippocampal IL-1beta expression was found in C57BL/6 mice after morphine treatment, whilst, a significant decrease was found in the mPFC region of wild-type Balb/c mice.	Morphine	90-98	interleukin 1 beta	Mus musculus	38-46
21501147-7	2011	Moreover, exogenous application of 2-AG or elevation of endogenous 2-AG by inhibiting its hydrolysis with URB602 or JZL184, selective inhibitors of monoacylglycerol lipase (MAGL), prevented the IL-1beta- and LPS-induced reduction of PPARgamma expression.	glyceryl 2-arachidonate	35-39	interleukin 1 beta	Mus musculus	194-202
21501147-7	2011	Moreover, exogenous application of 2-AG or elevation of endogenous 2-AG by inhibiting its hydrolysis with URB602 or JZL184, selective inhibitors of monoacylglycerol lipase (MAGL), prevented the IL-1beta- and LPS-induced reduction of PPARgamma expression.	glyceryl 2-arachidonate	67-71	interleukin 1 beta	Mus musculus	194-202
21501147-7	2011	Moreover, exogenous application of 2-AG or elevation of endogenous 2-AG by inhibiting its hydrolysis with URB602 or JZL184, selective inhibitors of monoacylglycerol lipase (MAGL), prevented the IL-1beta- and LPS-induced reduction of PPARgamma expression.	URB602	106-112	interleukin 1 beta	Mus musculus	194-202
21501147-7	2011	Moreover, exogenous application of 2-AG or elevation of endogenous 2-AG by inhibiting its hydrolysis with URB602 or JZL184, selective inhibitors of monoacylglycerol lipase (MAGL), prevented the IL-1beta- and LPS-induced reduction of PPARgamma expression.	JZL 184	116-122	interleukin 1 beta	Mus musculus	194-202
21356341-2	2011	Triterpenoid Acankoreanogenin A (AA) which is extracted from the leaves of the Acanthopanax gracilistylus W.W. Smith (AGS) has shown its inhibiting effect on TNF-alpha, IL-1beta and HMGB1 release in vitro in our preliminary experiments.	triterpenoid TP-222	0-12	interleukin 1 beta	Mus musculus	169-177
21569102-8	2011	The increased enzymatic activity of caspase-1 in the dorsal skin of the kanamycin-administered mice increased the mRNA expressions of IL-1beta and IL-18.	Kanamycin	72-81	interleukin 1 beta	Mus musculus	134-142
21569102-9	2011	The productions of IL-1beta and IL-18 were also increased in the splenocytes obtained from kanamycin-administered mice.	Kanamycin	91-100	interleukin 1 beta	Mus musculus	19-27
21356341-2	2011	Triterpenoid Acankoreanogenin A (AA) which is extracted from the leaves of the Acanthopanax gracilistylus W.W. Smith (AGS) has shown its inhibiting effect on TNF-alpha, IL-1beta and HMGB1 release in vitro in our preliminary experiments.	acankoreanogenin a	13-31	interleukin 1 beta	Mus musculus	169-177
21620566-6	2011	In addition, alpha,beta-amyrin largely decreased interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), keratinocyte-derived chemokine (KC) and interleukin 6 (IL-6) levels, and myeloperoxidase activity.	beta-amyrin	19-30	interleukin 1 beta	Mus musculus	49-66
21558879-6	2011	Furthermore, immunohistochemistry study showed that diabetes increased interleukin-6 (IL-6) and IL-1beta protein expression in atherosclerotic plaques, but alogliptin treatment attenuated diabetes-augmented IL-6 and IL-1beta expression.	alogliptin	156-166	interleukin 1 beta	Mus musculus	216-224
21620566-6	2011	In addition, alpha,beta-amyrin largely decreased interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), keratinocyte-derived chemokine (KC) and interleukin 6 (IL-6) levels, and myeloperoxidase activity.	beta-amyrin	19-30	interleukin 1 beta	Mus musculus	68-76
21596883-13	2011	Inhibition of caspase-1 activity using the selective inhibitor Ac-YVAD-CHO reduced SP and, less effectively, CGRP induced increases in IL-1beta production in REK cells.	L 709049	63-74	interleukin 1 beta	Mus musculus	135-143
21703408-4	2011	In vitro, cytokine release from zymosan-stimulated macrophages was affected by AP214, with approximately 80%, 30%, and 40% reduction in IL-1beta, tumor necrosis factor-alpha, and IL-6, respectively.	Zymosan	32-39	interleukin 1 beta	Mus musculus	136-173
21703408-5	2011	Inhibition of IL-1beta release was retained in MC(1) mutant cells but was lost in MC(3) null cells.	mc(1)	47-52	interleukin 1 beta	Mus musculus	14-22
21703408-5	2011	Inhibition of IL-1beta release was retained in MC(1) mutant cells but was lost in MC(3) null cells.	mc(3)	82-87	interleukin 1 beta	Mus musculus	14-22
21703412-10	2011	A DP agonist added to DCs in vitro was able to inhibit production of IL-12 and IL-1beta.	dp	2-4	interleukin 1 beta	Mus musculus	79-87
21644799-5	2011	Both GA and 18betaGA inhibited the activation of NF-kappaB and the activities of phosphoinositide-3-kinase (PI3K) p110delta and p110gamma isoforms and then reduced the production of LPS-induced tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and IL-1beta in a dose-dependent manner.	Glycyrrhizic Acid	5-7	interleukin 1 beta	Mus musculus	259-267
21596883-14	2011	The selective cathepsin B inhibitor CA-74Me inhibited neuropeptide induced IL-1beta production in REKs as well.	ca-74me	36-43	interleukin 1 beta	Mus musculus	75-83
21306580-6	2011	Peritoneal mouse macrophages showed less ATP-induced permeabilization to ethidium bromide in the presence of colchicine, and less reactive oxygen species (ROS) formation, nitric oxide (NO) and interleukin (IL)-1beta release.	Adenosine Triphosphate	41-44	interleukin 1 beta	Mus musculus	193-215
21951583-5	2011	3 In naive mice, responsiveness to MCh was significantly increased by the combination of IL-1beta and TNF-alpha, IL-13 alone or in combination with IL-1beta, but not by treatment with IL-1beta or TNF-alpha alone.	Methacholine Chloride	35-38	interleukin 1 beta	Mus musculus	148-156
21951583-5	2011	3 In naive mice, responsiveness to MCh was significantly increased by the combination of IL-1beta and TNF-alpha, IL-13 alone or in combination with IL-1beta, but not by treatment with IL-1beta or TNF-alpha alone.	Methacholine Chloride	35-38	interleukin 1 beta	Mus musculus	148-156
21951583-7	2011	4 In naive mice, albuterol sensitivity was only significantly attenuated by treatment with IL-1beta and TNF-alpha in combination.	Albuterol	17-26	interleukin 1 beta	Mus musculus	91-99
21951583-8	2011	In mice sensitized to OVA, albuterol sensitivity was significantly attenuated by treatment with TNF-alpha, IL-13 or IL-13 in combination with IL-1beta.	Albuterol	27-36	interleukin 1 beta	Mus musculus	142-150
21391981-9	2011	Dex-liposomes also down-regulated mRNA expression of IL-1beta and KC, but not of CCL2 (MCP-1) in lungs of LV(T) and HV(T) -ventilated mice.	Dextromethorphan	0-3	interleukin 1 beta	Mus musculus	53-61
21951583-5	2011	3 In naive mice, responsiveness to MCh was significantly increased by the combination of IL-1beta and TNF-alpha, IL-13 alone or in combination with IL-1beta, but not by treatment with IL-1beta or TNF-alpha alone.	Methacholine Chloride	35-38	interleukin 1 beta	Mus musculus	89-97
21306580-8	2011	Finally, in vivo assays with mice inoculated with lipopolysaccharide and ATP showed diminished ROS, IL-1beta, interferon-gamma and NO production after colchicine treatment.	Adenosine Triphosphate	73-76	interleukin 1 beta	Mus musculus	100-108
21306580-8	2011	Finally, in vivo assays with mice inoculated with lipopolysaccharide and ATP showed diminished ROS, IL-1beta, interferon-gamma and NO production after colchicine treatment.	Colchicine	151-161	interleukin 1 beta	Mus musculus	100-108
21488066-9	2011	Our novel data show that the saturated fatty acid (FA) palmitic acid (PA) activates the inflammasome and induces sensitization to LPS-induced IL-1beta release in hepatocytes.	Fatty Acids	29-49	interleukin 1 beta	Mus musculus	142-150
20844880-6	2011	The expression of IL-1beta induced by 5-FU in local intestinal tissue was examined by RT-PCR and immunohistochemistry.	Fluorouracil	38-42	interleukin 1 beta	Mus musculus	18-26
20844880-12	2011	RESULTS: The variation of IL-1beta expression induced by 5-FU was in accordance with the changes in intestinal apoptosis.	Fluorouracil	57-61	interleukin 1 beta	Mus musculus	26-34
20844880-18	2011	CONCLUSIONS: Our studies elucidate that IL-1beta is quite possibly involved in and mediated the course of intestinal apoptosis after 5-FU chemotherapy.	Fluorouracil	133-137	interleukin 1 beta	Mus musculus	40-48
21488066-9	2011	Our novel data show that the saturated fatty acid (FA) palmitic acid (PA) activates the inflammasome and induces sensitization to LPS-induced IL-1beta release in hepatocytes.	Palmitic Acid	55-68	interleukin 1 beta	Mus musculus	142-150
21488066-9	2011	Our novel data show that the saturated fatty acid (FA) palmitic acid (PA) activates the inflammasome and induces sensitization to LPS-induced IL-1beta release in hepatocytes.	Palmitic Acid	70-72	interleukin 1 beta	Mus musculus	142-150
20804404-10	2011	Gene expressions of interleukin-1beta (IL-1beta), IL-6, and CXCL1 in the mice treated with CyA (0.2 mg/kg/day)-MS and CyA (2 mg/kg/day)-MS were downregulated compared with CyA (0)-MS. CyA-MS might be possible to treat ulcerative colitis effectively by decreasing the total dosage without the elevation of the serum level or the side effects of CyA.	Cyclosporine	118-121	interleukin 1 beta	Mus musculus	20-37
21978695-7	2011	In the cell model of microglia stimulated by herpes simplex virus (HSV), with the ethanol extract intervention, TNF-alpha, IL-1beta and NO levels were significantly decreased and cell death of BV-2 cells were markedly increased.	Ethanol	82-89	interleukin 1 beta	Mus musculus	123-131
20804404-10	2011	Gene expressions of interleukin-1beta (IL-1beta), IL-6, and CXCL1 in the mice treated with CyA (0.2 mg/kg/day)-MS and CyA (2 mg/kg/day)-MS were downregulated compared with CyA (0)-MS. CyA-MS might be possible to treat ulcerative colitis effectively by decreasing the total dosage without the elevation of the serum level or the side effects of CyA.	Cyclosporine	118-121	interleukin 1 beta	Mus musculus	20-37
21411094-8	2011	This effect was comparable to that reported for complete genetic ablation of IL-1beta or IL-1R1 on an ApoE(-/-) background and was associated with decreases in plasma non-HDL/HDL cholesterol ratio and plaque lipid content and macrophage infiltration.	Cholesterol	179-190	interleukin 1 beta	Mus musculus	77-85
21193041-7	2011	The degree of staining for nitrotyrosine, iNOS, PAR, TNF-alpha and IL-1beta was markedly reduced in tissue sections obtained from zymosan-injected mice, which had received olprinone.	Zymosan	130-137	interleukin 1 beta	Mus musculus	67-75
21193041-7	2011	The degree of staining for nitrotyrosine, iNOS, PAR, TNF-alpha and IL-1beta was markedly reduced in tissue sections obtained from zymosan-injected mice, which had received olprinone.	olprinone	172-181	interleukin 1 beta	Mus musculus	67-75
21464611-0	2011	Doxorubicin and daunorubicin induce processing and release of interleukin-1beta through activation of the NLRP3 inflammasome.	Doxorubicin	0-11	interleukin 1 beta	Mus musculus	62-79
21464611-0	2011	Doxorubicin and daunorubicin induce processing and release of interleukin-1beta through activation of the NLRP3 inflammasome.	Daunorubicin	16-28	interleukin 1 beta	Mus musculus	62-79
21464611-5	2011	Elucidating the molecular basis by which anthracyclines upregulate IL-1beta activity may present opportunities to decrease the inflammatory consequences of these drugs.	Anthracyclines	41-55	interleukin 1 beta	Mus musculus	67-75
21464611-6	2011	Here we demonstrate that doxorubicin induces a systemic increase in IL-1beta and other inflammatory cytokines, chemokines and growth factors including TNF-alpha, IL-6, CXCL1/Gro-alpha, CCL2/MCP-1, granulocyte colony stimulating factor (GCSF), and CXCL10/IP-10.	Doxorubicin	25-36	interleukin 1 beta	Mus musculus	68-76
21464611-9	2011	Furthermore, doxorubicin and daunorubicin induced the processing and release of IL-1beta from LPS-primed BMDM by providing danger signals that lead to assembly and activation of the inflammasome.	Doxorubicin	13-24	interleukin 1 beta	Mus musculus	80-88
21464611-9	2011	Furthermore, doxorubicin and daunorubicin induced the processing and release of IL-1beta from LPS-primed BMDM by providing danger signals that lead to assembly and activation of the inflammasome.	Daunorubicin	29-41	interleukin 1 beta	Mus musculus	80-88
21464611-10	2011	The release of IL-1beta required the expression of ASC, caspase-1, and NLRP3, demonstrating that doxorubicin and daunorubicin-induced inflammation is mediated by the NLRP3 inflammasome.	Doxorubicin	97-108	interleukin 1 beta	Mus musculus	15-23
21464611-10	2011	The release of IL-1beta required the expression of ASC, caspase-1, and NLRP3, demonstrating that doxorubicin and daunorubicin-induced inflammation is mediated by the NLRP3 inflammasome.	Daunorubicin	113-125	interleukin 1 beta	Mus musculus	15-23
21464611-12	2011	These studies suggest that proinflammatory responses to anthracycline chemotherapeutic agents are mediated, at least in part, by promoting the processing and release of IL-1beta, and that some of the adverse inflammatory consequences that complicate chemotherapy with anthracyclines may be reduced by suppressing the actions of IL-1beta.	Anthracyclines	56-69	interleukin 1 beta	Mus musculus	169-177
21464611-12	2011	These studies suggest that proinflammatory responses to anthracycline chemotherapeutic agents are mediated, at least in part, by promoting the processing and release of IL-1beta, and that some of the adverse inflammatory consequences that complicate chemotherapy with anthracyclines may be reduced by suppressing the actions of IL-1beta.	Anthracyclines	56-69	interleukin 1 beta	Mus musculus	328-336
21464611-12	2011	These studies suggest that proinflammatory responses to anthracycline chemotherapeutic agents are mediated, at least in part, by promoting the processing and release of IL-1beta, and that some of the adverse inflammatory consequences that complicate chemotherapy with anthracyclines may be reduced by suppressing the actions of IL-1beta.	Anthracyclines	268-282	interleukin 1 beta	Mus musculus	169-177
21414392-3	2011	We found that glucocorticoid (dexamethasone) dramatically reduced lung injury, cellular inflammation and pro-inflammatory cytokine expression (TNF-alpha, IL-1beta and KC) but had no significant effect on silica-induced lung fibrosis and expression of the fibrogenic and suppressive cytokines TGF-beta and IL-10 in mice.	Dexamethasone	30-43	interleukin 1 beta	Mus musculus	154-162
21640075-7	2011	Captopril lowered the expression levels of TNF-alpha, IL-1beta, IL-6, and PAI-1 mRNAs, while telmisartan lowered the expression levels of COX-2, IL-1beta, IL-6, and PAI-1 mRNAs in the white adipose tissues of these mice.	Captopril	0-9	interleukin 1 beta	Mus musculus	54-62
21437599-7	2011	RESULTS: Pretreatment with pomalidomide significantly reduced the plasma levels of amylase and lipase; the histological injury; and the expression of TNF-alpha, IL-1beta, monocyte chemotactic protein-1 (MCP-1), and inducible nitric oxide synthase (iNOS) in cerulein-induced acute pancreatitis.	pomalidomide	27-39	interleukin 1 beta	Mus musculus	161-169
21367960-5	2011	Occurrence of colonic mucosal ulcer and dysplastic crypt induced by AOM/DSS treatment was also significantly decreased by the administration of diosgenin and sanyaku, which was in accordance with the significant reduction of AOM/DSS-mediated increases in expression of inflammatory cytokines such as IL-1beta by diosgenin and sanyaku.	dss	72-75	interleukin 1 beta	Mus musculus	300-308
21245403-12	2011	Ocular TNF-alpha, IL-1beta, and TLR4 transcripts and A2E were significantly lower in naloxone-treated DKO animals and cultured microglial cells than in controls, as were serum nitrite levels.	Naloxone	85-93	interleukin 1 beta	Mus musculus	18-26
21300114-6	2011	Wy-14643 and fenofibrate inhibited the elevations of TNFalpha, IL-1beta, IL-6, COX-2, ICAM-1, and VCAM-1.	Fenofibrate	13-24	interleukin 1 beta	Mus musculus	63-71
20605582-7	2011	The effects of naloxone on inhibiting IL-1beta up-regulation and NF-kappaB activation were enhanced by morphine.	Naloxone	15-23	interleukin 1 beta	Mus musculus	38-46
20605582-7	2011	The effects of naloxone on inhibiting IL-1beta up-regulation and NF-kappaB activation were enhanced by morphine.	Morphine	103-111	interleukin 1 beta	Mus musculus	38-46
20605582-8	2011	In contrast, the effects of naloxone on inhibiting IL-1beta up-regulation and I-kappaB degradation were counteracted by fentanyl.	Naloxone	28-36	interleukin 1 beta	Mus musculus	51-59
20605582-8	2011	In contrast, the effects of naloxone on inhibiting IL-1beta up-regulation and I-kappaB degradation were counteracted by fentanyl.	Fentanyl	120-128	interleukin 1 beta	Mus musculus	51-59
21501589-3	2011	In this study, we investigated the inhibitory effect and the molecular mechanism of the lipoxin A(4) (LXA(4)) on the production of interleukin-1beta (IL-1beta) and tumor necrosis factoralpha (TNFalpha) induced by beta-amyloid in the cortex and hippocampus of mice, and in Abeta-stimulated BV2 cells, a mouse microglial cell line.	lipoxin A4	88-97	interleukin 1 beta	Mus musculus	131-148
21183660-4	2011	Specifically, partial HIF-1alpha deficiency attenuated SMAO-induced increases in intestinal permeability, lipid peroxidation, mucosal caspase-3 activity, and IL-1beta mRNA levels.	smao	55-59	interleukin 1 beta	Mus musculus	158-166
21499285-7	2011	Treatment with Quin-C1 significantly reduced the neutrophil and lymphocyte counts in BALF, diminished expression of TNF-alpha, IL-1beta, KC, and TGF-beta1, and decreased collagen deposition in lung tissue.	4-butoxy-N-(2-(4-methoxy-phenyl)-4-oxo-1,4-dihydro-2H-quinazolin-3-yl)-benzamide	15-22	interleukin 1 beta	Mus musculus	127-135
21434774-7	2011	The concentration of serum cytokines (interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha) decreased in the radiation group treated with hesperidin at 50 and 200 mg/kg of body weight compared with the control group on Day 10 after irradiation.	Hesperidin	151-161	interleukin 1 beta	Mus musculus	38-55
21514415-4	2011	Bronchoalveolar lavage fluid concentrations of inflammatory cytokines (IL-1beta, IL-4, IL-6, IL-12 subunit p40, MIP1alpha, MIP1beta, and eotaxin) also were significantly less in asbestos-exposed OPN(-/-) mice.	Asbestos	178-186	interleukin 1 beta	Mus musculus	71-79
22977538-4	2011	Pre-treatment with PA at concentrations of 10, 20 or 40 muM dose-dependently decreased the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, nitric oxide (NO) and prostaglandin E(2) in LPS-stimulated RAW264.7 cells.	patchouli alcohol	19-21	interleukin 1 beta	Mus musculus	140-162
22977538-5	2011	In addition, PA treatment also reversed the increased mRNA expression of TNF-alpha, IL-1beta, IL-6, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 caused by LPS in RAW264.7 cells.	patchouli alcohol	13-15	interleukin 1 beta	Mus musculus	84-92
22977538-6	2011	These results indicate that PA is an important anti-inflammatory constituent of Pogostemonis Herba and that its anti-inflammatory effect may be mediated, at least in part, by down-regulation of the mRNA expression of a panel of inflammatory mediators, such as TNF-alpha, IL-1beta, IL-6, iNOS and COX-2.	patchouli alcohol	28-30	interleukin 1 beta	Mus musculus	271-279
21444764-5	2011	CO and cobalt protoporphyrin suppressed colonic IL-1beta, TNF, and IL-4 production, whereas IL-10 protein secretion was increased.	co and cobalt protoporphyrin	0-28	interleukin 1 beta	Mus musculus	48-56
21244371-6	2011	The colonic levels and expression of IL-1beta, CXCL-1/KC, MIP-2 and TNF-alpha were also reduced following therapeutic treatment with AS605240.	5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione	133-141	interleukin 1 beta	Mus musculus	37-45
21349269-9	2011	On the other hand, curcumin, either alone or combined with bone marrow transplantation, blunted the pancreatic lipid-peroxidation, up-regulated activities of the antioxidant enzymes, and suppressed serum levels of TNF-alpha and IL-1beta.	Curcumin	19-27	interleukin 1 beta	Mus musculus	228-236
21349270-11	2011	So, by immunohistochemical analysis and in vitro assays, we have clearly showed that glutamine reduces: 1) the histological damage in pancreas and gut; 2) the inducible nitric oxide synthase expression; 3) nitrotyrosine and poly (ADP-ribose) formation; 4) TNF-alpha and IL-1beta tissue and plasma levels; 5) FasL localization; and 6) alteration of the balance between Bax and Bcl-2.	Glutamine	85-94	interleukin 1 beta	Mus musculus	270-278
21352949-7	2011	Under AL, caffeine reduced the average daily mRNA levels of certain disease and inflammatory markers, such as liver alpha fetoprotein (Afp), C-reactive protein (Crp), jejunum alanine aminotransferase (Alt), growth arrest and DNA damage 45beta (Gadd45beta), Interleukin 1alpha (Il-1alpha), Il-1beta mRNA and serum plasminogen activator inhibitor 1 (PAI-1).	Caffeine	10-18	interleukin 1 beta	Mus musculus	289-297
21352949-8	2011	Under RF, caffeine reduced the average daily levels of Alt, Gadd45beta, Il-1alpha and Il-1beta mRNA in the jejunum, but not in the liver.	Caffeine	10-18	interleukin 1 beta	Mus musculus	86-94
21395581-1	2011	The potent pro-inflammatory cytokine, interleukin-1beta (IL-1beta), is synthesized as an inactive 33-kDa precursor (pro-IL-1beta) and is processed by caspase 1 into the bioactive 17-kDa mature form.	17-kda	179-185	interleukin 1 beta	Mus musculus	38-55
21395581-1	2011	The potent pro-inflammatory cytokine, interleukin-1beta (IL-1beta), is synthesized as an inactive 33-kDa precursor (pro-IL-1beta) and is processed by caspase 1 into the bioactive 17-kDa mature form.	17-kda	179-185	interleukin 1 beta	Mus musculus	57-65
21395581-1	2011	The potent pro-inflammatory cytokine, interleukin-1beta (IL-1beta), is synthesized as an inactive 33-kDa precursor (pro-IL-1beta) and is processed by caspase 1 into the bioactive 17-kDa mature form.	17-kda	179-185	interleukin 1 beta	Mus musculus	120-128
21395581-3	2011	We recently reported ATP induces the release of an unconventional 20-kDa form of IL-1beta (p20-IL-1beta) from lipopolysaccharide-primed microglial cells.	Adenosine Triphosphate	21-24	interleukin 1 beta	Mus musculus	81-89
21395581-3	2011	We recently reported ATP induces the release of an unconventional 20-kDa form of IL-1beta (p20-IL-1beta) from lipopolysaccharide-primed microglial cells.	Adenosine Triphosphate	21-24	interleukin 1 beta	Mus musculus	95-103
21395581-5	2011	Here, we investigated the pathways involved in the ATP-induced production of p20-IL-1beta using lipopolysaccharide-primed mouse microglial cells.	Adenosine Triphosphate	51-54	interleukin 1 beta	Mus musculus	81-89
22874716-4	2011	Vinpocetine inhibited the production of nitrite oxide and inflammatory factors such as interleukin-1beta (IL-1beta), IL-6 and tumour necrosis factor-alpha (TNF-alpha) in BV-2 microglia, in which cells were treated with LPS or exposed to OGD, regardless of the time Vinpocetine was added.	vinpocetine	0-11	interleukin 1 beta	Mus musculus	87-104
21395581-6	2011	The activation of P2X7 receptor by ATP triggered p20-IL-1beta production under acidic extracellular conditions.	Adenosine Triphosphate	35-38	interleukin 1 beta	Mus musculus	53-61
21395581-7	2011	ATP-induced p20-IL-1beta production was blocked by pepstatin A, a potent inhibitor of the lysosomal protease, cathepsin D.	Adenosine Triphosphate	0-3	interleukin 1 beta	Mus musculus	16-24
21395581-7	2011	ATP-induced p20-IL-1beta production was blocked by pepstatin A, a potent inhibitor of the lysosomal protease, cathepsin D.	pepstatin	51-62	interleukin 1 beta	Mus musculus	16-24
21395581-10	2011	Since facilitation of pore dilatation results in cytolysis accompanied with cytoplasmic pro-IL-1beta leakage, our data suggest the leaked pro-IL-1beta is processed into p20-IL-1beta by cathepsin D released after ATP stimulation under acidic extracellular conditions.	Adenosine Triphosphate	212-215	interleukin 1 beta	Mus musculus	142-150
21395581-10	2011	Since facilitation of pore dilatation results in cytolysis accompanied with cytoplasmic pro-IL-1beta leakage, our data suggest the leaked pro-IL-1beta is processed into p20-IL-1beta by cathepsin D released after ATP stimulation under acidic extracellular conditions.	Adenosine Triphosphate	212-215	interleukin 1 beta	Mus musculus	142-150
21333704-7	2011	In addition, capsaicin significantly lowered the KA-induced increase in the concentration of the cytokines IL-1beta and TNF-alpha in the brain.	Capsaicin	13-22	interleukin 1 beta	Mus musculus	107-115
22874716-4	2011	Vinpocetine inhibited the production of nitrite oxide and inflammatory factors such as interleukin-1beta (IL-1beta), IL-6 and tumour necrosis factor-alpha (TNF-alpha) in BV-2 microglia, in which cells were treated with LPS or exposed to OGD, regardless of the time Vinpocetine was added.	vinpocetine	0-11	interleukin 1 beta	Mus musculus	106-114
21372137-1	2011	Interleukin-1beta (IL-1beta) induces cell death in chondrocytes in a nitric oxide (NO)- and reactive oxygen species (ROS)-dependent manner.	Nitric Oxide	69-81	interleukin 1 beta	Mus musculus	0-17
21396389-2	2011	Recent studies implied that APAP-induced injury is partially mediated by interleukin-1beta (IL-1beta), which can activate and recruit neutrophils, exacerbating injury.	Acetaminophen	28-32	interleukin 1 beta	Mus musculus	73-90
21396389-2	2011	Recent studies implied that APAP-induced injury is partially mediated by interleukin-1beta (IL-1beta), which can activate and recruit neutrophils, exacerbating injury.	Acetaminophen	28-32	interleukin 1 beta	Mus musculus	92-100
21372137-10	2011	Furthermore, Mct-1 siRNA lowered the level of ROS generated after 15-h exposure to IL-1beta, whereas a ROS scavenger, N-acetylcysteine, suppressed both late phase degradation of IkappaBalpha and Nox-2 expression.	Reactive Oxygen Species	46-49	interleukin 1 beta	Mus musculus	83-91
21372137-11	2011	These results suggest that MCT-1 contributes to NOX-2 expression via late phase activation of NF-kappaB in a ROS-dependent manner in ATDC5 cells exposed to IL-1beta.	Reactive Oxygen Species	109-112	interleukin 1 beta	Mus musculus	156-164
21372137-1	2011	Interleukin-1beta (IL-1beta) induces cell death in chondrocytes in a nitric oxide (NO)- and reactive oxygen species (ROS)-dependent manner.	Nitric Oxide	69-81	interleukin 1 beta	Mus musculus	19-27
21372137-1	2011	Interleukin-1beta (IL-1beta) induces cell death in chondrocytes in a nitric oxide (NO)- and reactive oxygen species (ROS)-dependent manner.	Reactive Oxygen Species	92-115	interleukin 1 beta	Mus musculus	0-17
21372137-1	2011	Interleukin-1beta (IL-1beta) induces cell death in chondrocytes in a nitric oxide (NO)- and reactive oxygen species (ROS)-dependent manner.	Reactive Oxygen Species	92-115	interleukin 1 beta	Mus musculus	19-27
21372137-1	2011	Interleukin-1beta (IL-1beta) induces cell death in chondrocytes in a nitric oxide (NO)- and reactive oxygen species (ROS)-dependent manner.	Reactive Oxygen Species	117-120	interleukin 1 beta	Mus musculus	0-17
21372137-1	2011	Interleukin-1beta (IL-1beta) induces cell death in chondrocytes in a nitric oxide (NO)- and reactive oxygen species (ROS)-dependent manner.	Reactive Oxygen Species	117-120	interleukin 1 beta	Mus musculus	19-27
21372137-2	2011	In this study, increased production of lactate was observed in IL-1beta-treated mouse chondrocytic ATDC5 cells prior to the onset of their death.	Lactic Acid	39-46	interleukin 1 beta	Mus musculus	63-71
21372137-4	2011	Mct-1 knockdown also prevented IL-1beta-induced expression of phagocyte-type NADPH oxidase (NOX-2), an enzyme specialized for production of ROS, whereas it did not have an effect on inducible NO synthase.	Reactive Oxygen Species	140-143	interleukin 1 beta	Mus musculus	31-39
21129455-2	2011	Our data showed that CA and CS reduced the expression of IL-1beta and TNF-alpha but had less effect on fibronectin and ICAM-1 expression.	carnosol	28-30	interleukin 1 beta	Mus musculus	57-65
21497116-4	2011	Here, we showed that silica and alum induced lipopolysaccharide-primed macrophages to produce the lipid mediator prostaglandin E2 (PGE2) and interleukin-1beta (IL-1beta).	Silicon Dioxide	21-27	interleukin 1 beta	Mus musculus	141-158
21497116-4	2011	Here, we showed that silica and alum induced lipopolysaccharide-primed macrophages to produce the lipid mediator prostaglandin E2 (PGE2) and interleukin-1beta (IL-1beta).	Silicon Dioxide	21-27	interleukin 1 beta	Mus musculus	160-168
21497116-4	2011	Here, we showed that silica and alum induced lipopolysaccharide-primed macrophages to produce the lipid mediator prostaglandin E2 (PGE2) and interleukin-1beta (IL-1beta).	alum	32-36	interleukin 1 beta	Mus musculus	141-158
21497116-4	2011	Here, we showed that silica and alum induced lipopolysaccharide-primed macrophages to produce the lipid mediator prostaglandin E2 (PGE2) and interleukin-1beta (IL-1beta).	alum	32-36	interleukin 1 beta	Mus musculus	160-168
21296809-11	2011	AZM also significantly decreased messenger RNA expression levels of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and ICAM-1 in the cornea.	Azithromycin	0-3	interleukin 1 beta	Mus musculus	68-85
21296809-11	2011	AZM also significantly decreased messenger RNA expression levels of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and ICAM-1 in the cornea.	Azithromycin	0-3	interleukin 1 beta	Mus musculus	87-95
21296809-14	2011	This was further supported by an associated decrease in expression of IL-1beta, TNF-alpha, and ICAM-1 in the cornea, indicating AZM may have a potential anti-inflammatory effect on corneal inflammation.	Azithromycin	128-131	interleukin 1 beta	Mus musculus	70-78
21477330-0	2011	Expression of tumor necrosis factor-alpha and interleukin-1beta genes in the cochlea and inferior colliculus in salicylate-induced tinnitus.	Salicylates	112-122	interleukin 1 beta	Mus musculus	46-63
21477330-9	2011	mRNA expression levels for the IL-1beta gene also increased significantly in the salicylate group compared to the control group in both cochlea (3.50 +- 1.05 vs. 2.80 +- 0.28, p &lt; 0.0001) and IC (2.94 +- 0.51 versus 1.24 +- 0.52, p = 0.0013).	Salicylates	81-91	interleukin 1 beta	Mus musculus	31-39
21477330-12	2011	CONCLUSION: We conclude that salicylate treatment resulting in tinnitus augments expression of the TNF-alpha and IL-1beta genes in cochlea and IC of mice, and we suggest that these proinflammatory cytokines might lead to tinnitus directly or via modulating the NMDA receptor.	Salicylates	29-39	interleukin 1 beta	Mus musculus	113-121
21239632-4	2011	An analysis of the phenotype of isolated brain microvessels after nicotine exposure indicated higher expression of inflammatory mediators, cytokines (IL-1beta, TNF-alpha, and IL-18), chemokines (CCL2 and CX(3)CL1), and adhesion molecules (ICAM-1, VCAM-1, and P-selectins), and this was accompanied by enhanced leukocyte infiltration into brain during ischemia/reperfusion (P &lt; 0.01).	Nicotine	66-74	interleukin 1 beta	Mus musculus	150-158
21216815-13	2011	IAI of IL-1beta into C57BL6/Jax mice resulted in increased MMP17 expression in articular cartilage and increased GAG content in the synovial fluid.	Glycosaminoglycans	113-116	interleukin 1 beta	Mus musculus	7-15
21266011-4	2011	CBNP of 14 nm significantly induced acute lung inflammation in non-elicited subjects and aggravated PPE-elicited airway neutrophilic inflammation at an early stage (day 1), which was concomitant with the enhanced lung expression of pro-inflammatory cytokines such as interleukin-1beta and chemokine such as keratinocyte-derived chemoattractant.	ppe	100-103	interleukin 1 beta	Mus musculus	267-284
21091653-6	2011	KEY RESULTS: Both pre- and post-treatment with metformin significantly improved survival of animals during lethal endotoxaemia (survival rate was monitored up to 2 weeks), decreased serum levels of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta, HMGB1 expression and myeloperoxidase activity in lungs.	Metformin	47-56	interleukin 1 beta	Mus musculus	240-257
21130870-0	2011	TAK1 Lys-158 but not Lys-209 is required for IL-1beta-induced Lys63-linked TAK1 polyubiquitination and IKK/NF-kappaB activation.	Lysine	5-8	interleukin 1 beta	Mus musculus	45-53
21130870-4	2011	However, the lysine site that mediates Lys63-linked TAK1 polyubiquitination in IL-1beta signaling is still controversial.	Lysine	13-19	interleukin 1 beta	Mus musculus	79-87
21130870-5	2011	Here we report that TAK1 Lysine 158 but not Lysine 209 is required for IL-1beta-induced Lys63-linked TAK1 polyubiquitination and TAK1-mediated IKK, JNK, and p38 activation.	Lysine	25-31	interleukin 1 beta	Mus musculus	71-79
21195124-0	2011	Azithromycin inhibits macrophage interleukin-1beta production through inhibition of activator protein-1 in lipopolysaccharide-induced murine pulmonary neutrophilia.	Azithromycin	0-12	interleukin 1 beta	Mus musculus	33-50
20842678-4	2011	PA significantly inhibited the LPS-induced production of nitric oxide (NO), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	praeruptorin A	0-2	interleukin 1 beta	Mus musculus	76-93
21195124-4	2011	Using immunohistochemistry, mRNA and specific protein assays, we confirmed that azithromycin ameliorates LPS-induced pulmonary neutrophilia by inhibiting interleukin-1beta (IL-1beta) expression and production selectively in alveolar macrophages as well as in LPS-stimulated J774.2 macrophage-derived cells in vitro.	Azithromycin	80-92	interleukin 1 beta	Mus musculus	154-171
21195124-4	2011	Using immunohistochemistry, mRNA and specific protein assays, we confirmed that azithromycin ameliorates LPS-induced pulmonary neutrophilia by inhibiting interleukin-1beta (IL-1beta) expression and production selectively in alveolar macrophages as well as in LPS-stimulated J774.2 macrophage-derived cells in vitro.	Azithromycin	80-92	interleukin 1 beta	Mus musculus	173-181
21195124-7	2011	In conclusion, we have shown that inhibition of LPS-induced pulmonary neutrophilia and IL-1beta concentrations in lung tissue following azithromycin treatment is mediated through effects on alveolar macrophages.	Azithromycin	136-148	interleukin 1 beta	Mus musculus	87-95
21556222-7	2011	The water fraction of hawthorn fruit was determined to be safe and significantly inhibited NO production in LPS-stimulated RAW 264.7 cells and suppressed COX-2, TNF-alpha, IL-1beta, and IL-6 expression.	Water	4-9	interleukin 1 beta	Mus musculus	172-180
21556222-8	2011	The observed anti-inflammatory effects of the water fraction of hawthorn fruit might be attributed to the down-regulation of COX-2, TNF-alpha, IL-1beta, and IL-6 expression in LPS-stimulated RAW 264.7 cells.	Water	46-51	interleukin 1 beta	Mus musculus	143-151
20842678-4	2011	PA significantly inhibited the LPS-induced production of nitric oxide (NO), interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha).	praeruptorin A	0-2	interleukin 1 beta	Mus musculus	95-103
21228274-4	2011	After treatment of macrophages with Toll-like receptor ligands, pro-IL-1beta was specifically sequestered into autophagosomes, whereas further activation of autophagy with rapamycin induced the degradation of pro-IL-1beta and blocked secretion of the mature cytokine.	Sirolimus	172-181	interleukin 1 beta	Mus musculus	213-221
21199676-9	2011	Bicyclol also inhibited the release of TNF-alpha, IL-1beta and HMGB1, whereas simultaneously increased the expression of IL-10.	bicyclol	0-8	interleukin 1 beta	Mus musculus	50-58
21518517-7	2011	The 2 concentrations of quinacrine (12.6 mg/kg, 50.4 mg/kg) could suppress level of IL-1beta in serum induced by microwave irradiation.	Quinacrine	24-34	interleukin 1 beta	Mus musculus	84-92
21518517-9	2011	It is concluded that the quinacrine administration can delay the increase of peripheral granulocytes and lymphocytes inducted by microwave irradiation, and may partially suppress the rise of IL-1beta and IL-6 in serum.	Quinacrine	25-35	interleukin 1 beta	Mus musculus	191-199
21350203-6	2011	The SMTP-7-administered mice showed relatively mild rolling and attachment of leukocytes to the vascular wall in the middle cerebral vein, with weak peroxynitrite reactions and proinflammatory gene expression (IL-1beta, TNF-alpha, ICAM-1, and VCAM-1); thus, a small infarct volume compared with rt-PA-administered mice.	SMTP 7	4-10	interleukin 1 beta	Mus musculus	210-218
21228274-7	2011	Induction of autophagy in mice in vivo with rapamycin reduced serum levels of IL-1beta in response to challenge with LPS.	Sirolimus	44-53	interleukin 1 beta	Mus musculus	78-86
21268236-4	2011	Compared with a normal FBR elicited by silicone (SIL), PEG hydrogels without or with a cell adhesion ligand RGD elicited a strong early inflammatory response evidenced by a thick band of macrophages as early as day 2, persisting through two weeks, and by increased interleukin-1beta expression.	Polyethylene Glycols	55-58	interleukin 1 beta	Mus musculus	265-282
21147071-3	2011	Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by: infiltration of neutrophils in lung tissues and subsequent lipid peroxidation, increased production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) and increased expression of intercellular adhesion molecule (ICAM-1) and platelet-adhesion molecule (P-selectin).	Carrageenan	13-24	interleukin 1 beta	Mus musculus	262-279
21284090-5	2011	Additionally, resveratrol markedly decreased the production of inflammatory cytokines, including IL-1beta and MIP-1alpha and prevented the release of nitric oxide (NO) through inhibiting the expression of inducible NO synthase in lung tissues.	Resveratrol	14-25	interleukin 1 beta	Mus musculus	97-105
21147071-3	2011	Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by: infiltration of neutrophils in lung tissues and subsequent lipid peroxidation, increased production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) and increased expression of intercellular adhesion molecule (ICAM-1) and platelet-adhesion molecule (P-selectin).	Carrageenan	13-24	interleukin 1 beta	Mus musculus	281-289
21372039-7	2011	The serum levels of insulin, IGF-1, IGF-2, free fatty acid, and TNF-alpha were all decreased by drinking EGCG, which also decreased the expression of TNF-alpha, interleukin (IL)-6, IL-1beta, and IL-18 mRNAs in the livers.	epigallocatechin gallate	105-109	interleukin 1 beta	Mus musculus	181-189
21278344-0	2011	Cutting edge: cyclic polypeptide and aminoglycoside antibiotics trigger IL-1beta secretion by activating the NLRP3 inflammasome.	aminoglycoside antibiotics	37-63	interleukin 1 beta	Mus musculus	72-80
21278344-2	2011	In this article, we show that the aminoglycoside antibiotic neomycin, the cyclic lipopeptide antibiotic polymyxin B, and the cyclic peptide antibiotics gramicidin and tyrothricin can induce IL-1beta secretion in bone marrow dendritic cells and macrophages.	Aminoglycosides	34-48	interleukin 1 beta	Mus musculus	190-198
20579867-3	2011	Furthermore a significant decrease in mRNA levels of interleukin 1beta, interleukin 6, macrophage inflammatory protein 1alpha and inducible nitric oxide synthase was evident in response to the quercetin treatment.	Quercetin	193-202	interleukin 1 beta	Mus musculus	53-70
21278344-2	2011	In this article, we show that the aminoglycoside antibiotic neomycin, the cyclic lipopeptide antibiotic polymyxin B, and the cyclic peptide antibiotics gramicidin and tyrothricin can induce IL-1beta secretion in bone marrow dendritic cells and macrophages.	Neomycin	60-68	interleukin 1 beta	Mus musculus	190-198
21278344-2	2011	In this article, we show that the aminoglycoside antibiotic neomycin, the cyclic lipopeptide antibiotic polymyxin B, and the cyclic peptide antibiotics gramicidin and tyrothricin can induce IL-1beta secretion in bone marrow dendritic cells and macrophages.	cyclic peptide antibiotics	125-151	interleukin 1 beta	Mus musculus	190-198
21278344-2	2011	In this article, we show that the aminoglycoside antibiotic neomycin, the cyclic lipopeptide antibiotic polymyxin B, and the cyclic peptide antibiotics gramicidin and tyrothricin can induce IL-1beta secretion in bone marrow dendritic cells and macrophages.	Tyrothricin	167-178	interleukin 1 beta	Mus musculus	190-198
21278344-4	2011	All four antibiotics required the NLRP3 inflammasome, the adaptor ASC, and caspase-1 activation to secrete IL-1beta, a process that depended on potassium efflux but was independent of P2X7 receptor.	Potassium	144-153	interleukin 1 beta	Mus musculus	107-115
21129433-4	2011	Exposure to melphalan induced an early burst of the pro-inflammatory cytokines interleukin (IL)-1beta, IL-6 and IL-23 in airways, followed by extensive infiltration of neutrophils in the lung tissue and airways within 24h.	Melphalan	12-21	interleukin 1 beta	Mus musculus	79-101
20979017-5	2011	The results showed that polydatin treatment downregulated NF- kappaB p65 activity and expression, blocked the expression of TNF- alpha, IL-6 and IL-1 beta at both mRNA and protein levels, decreased myeloperoxidase (MPO) activity, and alleviated inflammatory damage of colitis in mice with UC (p &lt; 0.05), suggesting that the anti-inflammation effects of polydatin can be attributed, at least partially, to the blocking of the NF- kappaB pathway.	polydatin	24-33	interleukin 1 beta	Mus musculus	145-154
20926983-5	2011	LPS-provoked cardiac apoptosis, I-[kappa]B[alpha] phosphorylation, IL-1[beta], TNF-[alpha], and NO production were attenuated by pretreatment with Ber and/or yohimbine, whereas cardiac Toll-like receptor 4 mRNA expression, malondialdehyde content, and superoxide dismutase activity were not affected.	Yohimbine	158-167	interleukin 1 beta	Mus musculus	67-76
21151103-5	2011	Cytosolic mtDNA contributed to the secretion of IL-1beta and IL-18 in response to LPS and ATP.	Adenosine Triphosphate	90-93	interleukin 1 beta	Mus musculus	48-56
24278544-6	2011	In conclusion,the current study revealed the previously unknown effect of dichloromethane ethyl extract of Auricularia auricula-judae inhibitions of the production of NO, IL-6, TNF-alpha and IL-1beta in LPS-stimulated macrophages.	Methylene Chloride	74-89	interleukin 1 beta	Mus musculus	191-199
21147093-9	2011	LPS-induced phosphorylation of IkappaBalpha and p38 MAPK was blocked by Biochanin-A and it inhibited IL-6, IL-1beta and TNF-alpha production in RAW264.7 cells indicating its anti-inflammatory activity in association with anti-proliferation.	lps	0-3	interleukin 1 beta	Mus musculus	107-115
20850956-8	2011	Escin or Cort markedly reduced the content of NO, TNF-alpha and IL-1beta secreted by LPS-stimulated RAW264.7 macrophage cells.	Escin	0-5	interleukin 1 beta	Mus musculus	64-72
20850956-9	2011	The combination of suboptimal concentrations of escin with Cort, which alone could not markedly inhibit the release of inflammatory factors, inhibited the secretion of NO, TNF-alpha and IL-1beta in LPS-stimulated RAW264.7 macrophage cells.	Escin	48-53	interleukin 1 beta	Mus musculus	186-194
21166666-7	2011	We demonstrate that prostaglandin D2 is induced by lipopolysaccharide (LPS), a major component of Gram-negative bacteria, and that transtympanic injection of prostaglandin D2 up-regulates macrophage inflammatory protein 2 (MIP-2), interleukin (IL)-1beta and IL-6 in the middle ear.	Prostaglandin D2	20-36	interleukin 1 beta	Mus musculus	231-253
21279999-6	2011	RESULTS: OCP crystals induced peritoneal inflammation, as demonstrated by neutrophil recruitment and up-modulation of IL-1alpha, IL-1beta, and MRP-8-MRP-14 complex, to levels comparable with those induced by monosodium urate monohydrate crystals.	octacalcium phosphate	9-12	interleukin 1 beta	Mus musculus	129-137
21166666-7	2011	We demonstrate that prostaglandin D2 is induced by lipopolysaccharide (LPS), a major component of Gram-negative bacteria, and that transtympanic injection of prostaglandin D2 up-regulates macrophage inflammatory protein 2 (MIP-2), interleukin (IL)-1beta and IL-6 in the middle ear.	Prostaglandin D2	158-174	interleukin 1 beta	Mus musculus	231-253
21166666-8	2011	We also show that middle ear inflammatory reactions, including infiltration of inflammatory cells and expression of MIP-2, IL-1beta and IL-6 induced by LPS, are reduced significantly in DP-(/)- mice and DP-(/)- CRTH2-(/)- mice.	dp	186-188	interleukin 1 beta	Mus musculus	123-131
21095216-8	2011	Increased plasma proinflammatory cytokines, tumor necrosis factor and interleukin-1beta, in BDL mice were further elevated by TCDD pretreatment.	Polychlorinated Dibenzodioxins	126-130	interleukin 1 beta	Mus musculus	70-87
20883476-9	2011	In the Cg model, 15d-PGJ2-NC markedly inhibited serum levels of the pro-inflammatory cytokines TNF-alpha, IL-1beta and IL-12p70.	15d-pgj2-nc	17-28	interleukin 1 beta	Mus musculus	106-114
21166666-8	2011	We also show that middle ear inflammatory reactions, including infiltration of inflammatory cells and expression of MIP-2, IL-1beta and IL-6 induced by LPS, are reduced significantly in DP-(/)- mice and DP-(/)- CRTH2-(/)- mice.	dp	203-205	interleukin 1 beta	Mus musculus	123-131
21050164-7	2011	The expression of HSP70 and inflammatory cytokine IL-1beta, increased in the three AAS-treated groups.	aas	83-86	interleukin 1 beta	Mus musculus	50-58
21094290-0	2011	Paeoniflorin improves survival in LPS-challenged mice through the suppression of TNF-alpha and IL-1beta release and augmentation of IL-10 production.	peoniflorin	0-12	interleukin 1 beta	Mus musculus	95-103
20824662-8	2011	Among DSS-responsive genes, those for inflammatory cytokines (IL-1beta, CD14 antigen and tumor necrosis factor receptor superfamily, member 1b), membrane remodeling genes (matrix metalloproteinase-3, -10 and -13) and acute phase proteins (S100 calcium-binding protein A8), which were increased by DSS, were downregulated by DHA or SAL treatment.	Dextran Sulfate	6-9	interleukin 1 beta	Mus musculus	62-70
21143491-6	2011	PD+AL group presented decreased tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, interferon-gamma, IL-17A, receptor activator of nuclear factor kappa-light-chain-enhancer of activated B cells ligand and matrix metalloproteinase (MMP)-13 levels in periodontal tissues, while IL-4 and IL-10 levels were unaltered by AL co-induction.	Aluminum	3-5	interleukin 1 beta	Mus musculus	74-96
20950131-9	2011	Protein concentration of IL-1beta, IL-6 (section 3), and CCL2 was increased (P &lt; 0.05) and curcumin reduced this response for IL-1beta (section 2) and CCL2 (P &lt; 0.05).	Curcumin	94-102	interleukin 1 beta	Mus musculus	129-137
21097822-6	2011	We show that chronic, but not acute, cholesterol feeding increases the expression of hepatic inflammatory cytokines, tumor necrosis factor (TNF)alpha, and interleukin (IL)-1beta, which are known to suppress hepatic CYP7A1 expression.	Cholesterol	37-48	interleukin 1 beta	Mus musculus	155-177
21093515-5	2011	Xanthohumol significantly inhibited the excessive production of inflammatory mediators NO, IL-1beta, and TNF-alpha, and the activation of NF-kappaB signaling in LPS-induced stimulated BV2 cells.	xanthohumol	0-11	interleukin 1 beta	Mus musculus	91-99
21040784-11	2011	Pretreatment with escin could decrease the mortality rate, attenuate lung injury resulted from LPS, down-regulate the level of the inflammation mediators, including NO, TNF-alpha, and IL-1beta, enhance the endogenous antioxidant capacity, and up-regulating the GR expression in lung.	Escin	18-23	interleukin 1 beta	Mus musculus	184-192
20661184-7	2011	Pretreatment with kinsenoside decreased serum levels of TNF-[alpha], IL-1[beta], IL-10, monocyte chemoattractant protein 1, and migration inhibitory factor at 1 h after sublethal dose of LPS (40 mg/kg, i.p.)	3-glucopyranosyloxybutanolide	18-29	interleukin 1 beta	Mus musculus	69-78
20720515-6	2011	in combination with imipenem (1 mg/kg s.c.) 1 h after CLP significantly increased the survival rates of mice from 17% to 50% (P &lt;= 0.01) and suppressed CLP-induced increases in serum levels of IL-1[beta], IL-6, IL-10, and macrophage inflammatory protein 2 by 64%, 73%, 79%, and 81%, respectively (P &lt;= 0.025).	Imipenem	20-28	interleukin 1 beta	Mus musculus	196-205
20661184-2	2011	In LPS-stimulated mouse peritoneal lavage macrophages, kinsenoside inhibited the inflammatory mediators, such as nitric oxide, TNF-[alpha], IL-1[beta], monocyte chemoattractant protein 1, and macrophage migration inhibitory factor production.	3-glucopyranosyloxybutanolide	55-66	interleukin 1 beta	Mus musculus	140-149
20816670-6	2011	In Raw264.7 cells, 8-OHdG was found to be associated with marked attenuations of NOX1, NOXO1, and NOXA1 accompanied with the decreased expressions of LPS-induced inflammatory mediators including COX-2, iNOS, IL-1beta, and IL-6.	8-ohdg	19-25	interleukin 1 beta	Mus musculus	208-216
21415531-7	2011	Our results demonstrated that SKLB010 diminished the increase of macrophage, neutrophil and lymphocyte counts as well as the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 in bronchoalveolar lavage fluid on day 14 (p&lt;0.05).	5-(4-methoxybenzylidene)thiazolidine-2,4-dione	30-37	interleukin 1 beta	Mus musculus	176-198
22130237-0	2011	Tacrolimus ameliorates dextran sulfate sodium-induced colitis in mice: implication of interferon-gamma and interleukin-1beta suppression.	Tacrolimus	0-10	interleukin 1 beta	Mus musculus	107-124
22130237-5	2011	Treatment with tacrolimus for 14 d reduced the colon weight per unit length and suppressed the release of IFN-gamma and IL-1beta, but not other cytokines, in inflamed colons of colitic mice compared with vehicle-treated mice.	Tacrolimus	15-25	interleukin 1 beta	Mus musculus	120-128
22130237-7	2011	The release of IFN-gamma and IL-1beta was also suppressed after single dosing with tacrolimus to colitic mice.	Tacrolimus	83-93	interleukin 1 beta	Mus musculus	29-37
22130237-8	2011	Taken together, these results suggested that tacrolimus ameliorated DSS-induced colitis by suppressing release of IFN-gamma and IL-1beta from inflamed colon.	Tacrolimus	45-55	interleukin 1 beta	Mus musculus	128-136
22130237-8	2011	Taken together, these results suggested that tacrolimus ameliorated DSS-induced colitis by suppressing release of IFN-gamma and IL-1beta from inflamed colon.	Dextran Sulfate	68-71	interleukin 1 beta	Mus musculus	128-136
21097717-5	2011	We show that tumors treated with tamoxifen and fed Flax or ENL exhibited decreased in vivo release of IL-1beta derived from the murine stroma and decreased microvessel density whereas dietary GEN had no effects.	Tamoxifen	33-42	interleukin 1 beta	Mus musculus	102-110
20942867-7	2011	KEY RESULTS: Hypernociception was dependent on antigen dose and the time after its administration; it was prevented by treatment with morphine and associated with neutrophil infiltration and local production of TNF-alpha, IL-1beta and CXCL-1.	Morphine	134-142	interleukin 1 beta	Mus musculus	222-230
20942867-9	2011	Treatment with fucoidin (a leucocyte adhesion inhibitor) greatly suppressed neutrophil influx and local production of TNF-alpha and IL-1beta, and hypernociception.	fucoidan	15-23	interleukin 1 beta	Mus musculus	132-140
21071580-10	2011	The serum levels of TNF-alpha and the expression levels of TNF- alpha, IL-6, and IL-1 beta mRNA in the livers of DEN-treated db/db mice were decreased by ACR treatment, suggesting attenuation of the chronic inflammation induced by excessive fatty deposits.	Diethylnitrosamine	113-116	interleukin 1 beta	Mus musculus	81-90
18955361-7	2011	Antroquinonol significantly inhibited the production of tumor necrosis factor-alpha and interleukin-1beta by 75 and 78%, respectively.	antroquinonol	0-13	interleukin 1 beta	Mus musculus	88-105
20974250-5	2011	Additionally, 4-O-methylhonokiol prevented PS2 mutation-induced activation of astrocytes as well as production of TNF-alpha, IL-1beta, reactive oxygen species (ROS), and nitric oxide (NO) in neurons.	4-O-methylhonokiol	14-32	interleukin 1 beta	Mus musculus	125-133
20690072-7	2011	The results showed that administration with aspirin for 4 weeks or 8 weeks significantly reduced the mean escape latency, the acetylcholinesterase activity, the TNF-alpha, IL-1beta levels and increased the percentage of time spent in target quadrant.	Aspirin	44-51	interleukin 1 beta	Mus musculus	172-180
21239739-13	2011	Protein levels and mRNA expressions of interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha were inhibited by EPPF or RA administration in the nasal mucosa tissue or spleen of OVA-sensitized mice.	rosmarinic acid	126-128	interleukin 1 beta	Mus musculus	39-61
20974250-6	2011	Generation of TNF-alpha, IL-1beta, ROS, and NO and ERK activation in cultured astrocytes treated with lipopolysaccharide (1mug/ml) were also prevented by 4-O-methylhonokiol in a dose-dependent manner.	4-O-methylhonokiol	154-172	interleukin 1 beta	Mus musculus	25-33
21059391-6	2011	To further understand how it works, we examined several proinflammatory markers including neutrophil infiltration in organs and TNF-alpha and IL-1beta in serum, and found that these cytokines were significantly reduced by chitosan oligosaccharide treatment.	D-Glucosaminide	222-246	interleukin 1 beta	Mus musculus	142-150
21282739-1	2011	BACKGROUND/AIM: The inhibition of the mevalonate pathway through genetic defects such as mevalonate kinase deficiency (MKD) or pharmacological drugs such as aminobisphosphonates causes a shortage of intermediate compounds, in particular geranylgeranyl-pyrophosphate (GGPP), which is associated with the consequent augmented IL-1beta release in monocytes.	Mevalonic Acid	38-48	interleukin 1 beta	Mus musculus	324-332
21282739-1	2011	BACKGROUND/AIM: The inhibition of the mevalonate pathway through genetic defects such as mevalonate kinase deficiency (MKD) or pharmacological drugs such as aminobisphosphonates causes a shortage of intermediate compounds, in particular geranylgeranyl-pyrophosphate (GGPP), which is associated with the consequent augmented IL-1beta release in monocytes.	aminobisphosphonates	157-177	interleukin 1 beta	Mus musculus	324-332
21441617-0	2011	Noradrenaline release in rodent tissues is inhibited by interleukin-1beta but is not affected by urotensin II, MCH, NPW and NPFF.	Norepinephrine	0-13	interleukin 1 beta	Mus musculus	56-73
20938211-5	2011	In MPTP-treated animals we observed a significant increase in IL-1beta, TNF-alpha and IL-6 mRNA expression levels both in the SN and CP in comparison with untreated mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	3-7	interleukin 1 beta	Mus musculus	62-70
21496386-4	2011	This fraction was found to be composed primarily of saccharides and in vitro intensively stimulated mouse peritoneal macrophages that produce Th1 inflammatory cytokines such as tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), interferon-gamma (IFN-gamma), and interleukin-6 (IL-6).	Carbohydrates	52-63	interleukin 1 beta	Mus musculus	217-234
21496386-4	2011	This fraction was found to be composed primarily of saccharides and in vitro intensively stimulated mouse peritoneal macrophages that produce Th1 inflammatory cytokines such as tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), interferon-gamma (IFN-gamma), and interleukin-6 (IL-6).	Carbohydrates	52-63	interleukin 1 beta	Mus musculus	236-244
21074783-8	2011	The concentrations of pro-inflammatory cytokines interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha were elevated in bronchoalveolar lavage fluid (BALF) after LPS administration, which were significantly inhibited by GL pretreatment.	Glycyrrhizic Acid	227-229	interleukin 1 beta	Mus musculus	49-71
20844471-3	2011	Three days following cisplatin injection, wild-type mice displayed renal functional and structural abnormalities consistent with nephrotoxicity accompanied by elevated circulating and renal levels of TNF-alpha and renal levels of IL-1beta, subunits of NADPH oxidase, thiobarbituric acid-reactive substances, and PGE(2).	Cisplatin	21-30	interleukin 1 beta	Mus musculus	230-238
21441617-3	2011	In mouse brain cortex, interleukin-1beta at 0.3 nM and the prostaglandin E2 analogue sulprostone at 3 nM inhibited noradrenaline release by about 40% the effect of interleukin-1beta developed gradually, whereas the effect of sulprostone occurred promptly.	Dinoprostone	59-75	interleukin 1 beta	Mus musculus	164-181
21441617-3	2011	In mouse brain cortex, interleukin-1beta at 0.3 nM and the prostaglandin E2 analogue sulprostone at 3 nM inhibited noradrenaline release by about 40% the effect of interleukin-1beta developed gradually, whereas the effect of sulprostone occurred promptly.	sulprostone	85-96	interleukin 1 beta	Mus musculus	164-181
21441617-3	2011	In mouse brain cortex, interleukin-1beta at 0.3 nM and the prostaglandin E2 analogue sulprostone at 3 nM inhibited noradrenaline release by about 40% the effect of interleukin-1beta developed gradually, whereas the effect of sulprostone occurred promptly.	Norepinephrine	115-128	interleukin 1 beta	Mus musculus	23-40
22001991-5	2011	L-998 inhibited LPS-induced production of TNF-alpha and IL-1beta and did not alter KC and MCP-1 levels.	ethyl 6-cyclohexylurea-(1,3)dioxolo(5,4-g)quinoline-7-carboxylate	0-5	interleukin 1 beta	Mus musculus	56-64
21441617-3	2011	In mouse brain cortex, interleukin-1beta at 0.3 nM and the prostaglandin E2 analogue sulprostone at 3 nM inhibited noradrenaline release by about 40% the effect of interleukin-1beta developed gradually, whereas the effect of sulprostone occurred promptly.	sulprostone	225-236	interleukin 1 beta	Mus musculus	23-40
21441617-3	2011	In mouse brain cortex, interleukin-1beta at 0.3 nM and the prostaglandin E2 analogue sulprostone at 3 nM inhibited noradrenaline release by about 40% the effect of interleukin-1beta developed gradually, whereas the effect of sulprostone occurred promptly.	sulprostone	225-236	interleukin 1 beta	Mus musculus	164-181
22216309-2	2011	Previous studies identified a class of diarylsulfonylurea containing compounds called Cytokine Release Inhibitory Drugs (CRIDs) that inhibited the post-translational processing of IL-1beta.	diarylsulfonylurea	39-57	interleukin 1 beta	Mus musculus	180-188
22358096-5	2011	It was found that bestatin administered at doses of 1 and 0.1 mg/kg five times on alternating days increased the synthesis and release of IL-1beta by resident peritoneal murine macrophages stimulated in vitro with LPS in cyclophosphamide-treated mice.	ubenimex	18-26	interleukin 1 beta	Mus musculus	138-146
22358096-5	2011	It was found that bestatin administered at doses of 1 and 0.1 mg/kg five times on alternating days increased the synthesis and release of IL-1beta by resident peritoneal murine macrophages stimulated in vitro with LPS in cyclophosphamide-treated mice.	Cyclophosphamide	221-237	interleukin 1 beta	Mus musculus	138-146
22216309-4	2011	This study aimed to investigate the mechanism of the inhibitory activity of the CRID CP-456,773 (termed CRID3) in light of recent advances in the area of inflammasome activation, and to clarify the potential role of GSTO1 in the regulation of IL-1beta production.	cp-456	85-91	interleukin 1 beta	Mus musculus	243-251
22164245-7	2011	Remarkably, CCI induced TNF (p&lt;0.01), IL-1beta (p&lt;0.05), IL-10 (p&lt;0.05), and IL-13 (p&lt;0.001) gene expression exclusively in the ipsilateral spinal cord of IL-4 ko mice.	CCI	12-15	interleukin 1 beta	Mus musculus	41-49
22439331-1	2011	The objective of this study was to determine the effect of a nonionic silver nanocolloid administered orally for 7 or 14 days at three concentration levels (25 ppm, 2.5 ppm, and 0.25 ppm) on the phagocytic activity and mitogenic response of splenocytes and selected cytokine serum levels (IL-1beta, IL-6, IL-10, IL-12 p70, TNF-alpha) in NMRI mice at the early stage of experimental endotoxemia induced with single 30 microg/mouse dose of bacterial LPS.	silver nanocolloid	70-88	interleukin 1 beta	Mus musculus	289-297
22073162-9	2011	Xenon pretreatment also reduced the plasma level increase of IL-1beta induced by surgery (P = 0.028).	Xenon	0-5	interleukin 1 beta	Mus musculus	61-69
21625424-0	2011	Polyene macrolide antifungal drugs trigger interleukin-1beta secretion by activating the NLRP3 inflammasome.	polyene macrolide	0-17	interleukin 1 beta	Mus musculus	43-60
21625424-2	2011	However, amphotericin and nystatin have been reported to also trigger interleukin-1beta (IL-1beta) secretion in monocytes but the molecular mechanism is unknown.	Amphotericin B	9-21	interleukin 1 beta	Mus musculus	70-87
21625424-2	2011	However, amphotericin and nystatin have been reported to also trigger interleukin-1beta (IL-1beta) secretion in monocytes but the molecular mechanism is unknown.	Amphotericin B	9-21	interleukin 1 beta	Mus musculus	89-97
21625424-2	2011	However, amphotericin and nystatin have been reported to also trigger interleukin-1beta (IL-1beta) secretion in monocytes but the molecular mechanism is unknown.	Nystatin	26-34	interleukin 1 beta	Mus musculus	70-87
22114704-5	2011	Muramyl dipeptide (MDP, a Nod2 ligand) + PGN co-stimulated macrophages have lower expression of IL1beta than PGN (TLR2/1 ligand) stimulated macrophages.	Acetylmuramyl-Alanyl-Isoglutamine	0-17	interleukin 1 beta	Mus musculus	96-103
22114704-5	2011	Muramyl dipeptide (MDP, a Nod2 ligand) + PGN co-stimulated macrophages have lower expression of IL1beta than PGN (TLR2/1 ligand) stimulated macrophages.	Acetylmuramyl-Alanyl-Isoglutamine	19-22	interleukin 1 beta	Mus musculus	96-103
21625424-2	2011	However, amphotericin and nystatin have been reported to also trigger interleukin-1beta (IL-1beta) secretion in monocytes but the molecular mechanism is unknown.	Nystatin	26-34	interleukin 1 beta	Mus musculus	89-97
21625424-3	2011	Here we report that only the polyene macrolides amphotericin B, nystatin, and natamycin but none of the tested azole antimycotic drugs induce significant IL-1beta secretion in-vitro in dendritic cells isolated from C57BL/6 mouse bone marrow.	polyene macrolides	29-47	interleukin 1 beta	Mus musculus	154-162
21625424-3	2011	Here we report that only the polyene macrolides amphotericin B, nystatin, and natamycin but none of the tested azole antimycotic drugs induce significant IL-1beta secretion in-vitro in dendritic cells isolated from C57BL/6 mouse bone marrow.	Amphotericin B	48-62	interleukin 1 beta	Mus musculus	154-162
21625424-3	2011	Here we report that only the polyene macrolides amphotericin B, nystatin, and natamycin but none of the tested azole antimycotic drugs induce significant IL-1beta secretion in-vitro in dendritic cells isolated from C57BL/6 mouse bone marrow.	Nystatin	64-72	interleukin 1 beta	Mus musculus	154-162
21625424-6	2011	Natamycin-induced IL-1beta secretion also involved phagocytosis, as cathepsin activation as described for crystal-induced IL-1beta release.	Natamycin	0-9	interleukin 1 beta	Mus musculus	18-26
21625424-6	2011	Natamycin-induced IL-1beta secretion also involved phagocytosis, as cathepsin activation as described for crystal-induced IL-1beta release.	Natamycin	0-9	interleukin 1 beta	Mus musculus	122-130
21625424-7	2011	Together, the polyene macrolides amphotericin B, nystatin, and natamycin trigger IL-1beta secretion by causing potassium efflux from which activates the NLRP3-ASC-caspase-1.	polyene macrolides	14-32	interleukin 1 beta	Mus musculus	81-89
21659722-10	2011	The numbers of inflammatory cells and levels of IL-6, IL-1beta and tumor necrosis factor-alpha were decreased in the imatinib and nilotinib groups on days 3 and 7.	Imatinib Mesylate	117-125	interleukin 1 beta	Mus musculus	54-94
21625424-7	2011	Together, the polyene macrolides amphotericin B, nystatin, and natamycin trigger IL-1beta secretion by causing potassium efflux from which activates the NLRP3-ASC-caspase-1.	Amphotericin B	33-47	interleukin 1 beta	Mus musculus	81-89
21625424-7	2011	Together, the polyene macrolides amphotericin B, nystatin, and natamycin trigger IL-1beta secretion by causing potassium efflux from which activates the NLRP3-ASC-caspase-1.	Nystatin	49-57	interleukin 1 beta	Mus musculus	81-89
21625424-7	2011	Together, the polyene macrolides amphotericin B, nystatin, and natamycin trigger IL-1beta secretion by causing potassium efflux from which activates the NLRP3-ASC-caspase-1.	Natamycin	63-72	interleukin 1 beta	Mus musculus	81-89
21625424-7	2011	Together, the polyene macrolides amphotericin B, nystatin, and natamycin trigger IL-1beta secretion by causing potassium efflux from which activates the NLRP3-ASC-caspase-1.	Potassium	111-120	interleukin 1 beta	Mus musculus	81-89
20664191-8	2011	RESULTS: Nicotine pretreatment significantly attenuated the severity of lung injury and inhibited the production of TNF-alpha, IL-1beta and HMGB-1 in mice with ALI.	Nicotine	9-17	interleukin 1 beta	Mus musculus	127-135
21659722-10	2011	The numbers of inflammatory cells and levels of IL-6, IL-1beta and tumor necrosis factor-alpha were decreased in the imatinib and nilotinib groups on days 3 and 7.	nilotinib	130-139	interleukin 1 beta	Mus musculus	54-94
21200439-7	2010	We found that mTORC1-S6K suppression by rapamycin delayed mortality of mice challenged with lethal endotoxin, and was associated with dampened circulating levels of VEGF, IL-1beta, IFN-gamma and IL-5.	Sirolimus	40-49	interleukin 1 beta	Mus musculus	171-179
21170503-7	2010	Furthermore, (S)-4C3HPG treatment also decreased the glutamate concentration in CSF and the expressions of TNF-alpha and IL-1beta mRNA remarkably in a dose-dependent manner.	(S)-4-CARBOXY-3-HYDROXYPHENYLGLYCINE	13-23	interleukin 1 beta	Mus musculus	121-129
20826012-4	2010	Treatment with the transcriptional activator retinoic acid (RA) suppressed mRNA expression and protein release of several important cytokines (IL-1beta 4%, IL-6 21%, TNFalpha 30%, IL-12p40 42%, and IL-12p35/p40 27%; p&lt;0.01).	Tretinoin	45-58	interleukin 1 beta	Mus musculus	143-151
21162750-10	2010	Low concentrations of delta-Tocotrienols (&lt; 20 muM) blocked LPS-induced gene expression of TNF-alpha, IL-1beta, IL-6 and iNOS (&gt; 40%), while higher concentrations (40 muM) increased gene expression of the latter in peritoneal macrophages (prepared from BALB/c mice) as compared to control group.	tocotrienol, delta	22-40	interleukin 1 beta	Mus musculus	105-113
20826012-4	2010	Treatment with the transcriptional activator retinoic acid (RA) suppressed mRNA expression and protein release of several important cytokines (IL-1beta 4%, IL-6 21%, TNFalpha 30%, IL-12p40 42%, and IL-12p35/p40 27%; p&lt;0.01).	Tretinoin	60-62	interleukin 1 beta	Mus musculus	143-151
20971730-3	2010	The objective of this study is to evaluate the role of interleukin (IL)-1beta in enhanced extra-intestinal thrombosis observed in mice with dextran sodium sulfate (DSS)-induced colitis.	dextran sodium sulfate	140-162	interleukin 1 beta	Mus musculus	55-77
20831192-4	2010	DHA and EPA inhibited LPS-induced COX-2, iNOS, IL-1beta, IL-6, or TNF-alpha, but increased hemeoxygenase (HO-1) expression.	Docosahexaenoic Acids	0-3	interleukin 1 beta	Mus musculus	47-55
20831192-4	2010	DHA and EPA inhibited LPS-induced COX-2, iNOS, IL-1beta, IL-6, or TNF-alpha, but increased hemeoxygenase (HO-1) expression.	Eicosapentaenoic Acid	8-11	interleukin 1 beta	Mus musculus	47-55
20831192-5	2010	DHA was found to be more potent than EPA in inhibiting COX-2, iNOS, IL-1beta, IL-6, and TNF-alpha mRNA expression.	Docosahexaenoic Acids	0-3	interleukin 1 beta	Mus musculus	68-76
20831192-5	2010	DHA was found to be more potent than EPA in inhibiting COX-2, iNOS, IL-1beta, IL-6, and TNF-alpha mRNA expression.	Eicosapentaenoic Acid	37-40	interleukin 1 beta	Mus musculus	68-76
21048113-4	2010	After stimulation with ATP, an agonist of the NLRP3 inflammasome, knockdown of TRIM30 enhanced caspase-1 activation and increased production of IL-1beta in both J774 cells and bone marrow-derived macrophages.	Adenosine Triphosphate	23-26	interleukin 1 beta	Mus musculus	144-152
21048113-5	2010	Similarly with ATP, knockdown of TRIM30 increased caspase-1 activation and IL-1beta production triggered by other NLRP3 inflammasome agonists, including nigericin, monosodium urate, and silica.	Nigericin	153-162	interleukin 1 beta	Mus musculus	75-83
21048113-5	2010	Similarly with ATP, knockdown of TRIM30 increased caspase-1 activation and IL-1beta production triggered by other NLRP3 inflammasome agonists, including nigericin, monosodium urate, and silica.	Silicon Dioxide	186-192	interleukin 1 beta	Mus musculus	75-83
21048113-6	2010	Production of reactive oxygen species was increased in TRIM30 knockdown cells, and its increase was required for enhanced NLRP3 inflammasome activation, because antioxidant treatment blocked excess IL-1beta production.	Reactive Oxygen Species	14-37	interleukin 1 beta	Mus musculus	198-206
20971730-3	2010	The objective of this study is to evaluate the role of interleukin (IL)-1beta in enhanced extra-intestinal thrombosis observed in mice with dextran sodium sulfate (DSS)-induced colitis.	dss	164-167	interleukin 1 beta	Mus musculus	55-77
20861081-0	2010	Follistatin-like 1 regulates renal IL-1beta expression in cisplatin nephrotoxicity.	Cisplatin	58-67	interleukin 1 beta	Mus musculus	35-43
20971730-7	2010	DSS-induced thrombogenesis was evaluated in WT mice treated with an IL-1beta antibody and in IL-1 receptor-deficient (IL-1r(-/-)) mice.	dss	0-3	interleukin 1 beta	Mus musculus	68-76
20861081-7	2010	We find that although TNF-alpha and Il6 levels are unchanged relative to wild-type, renal Il-1beta expression is increased in genetrap mice following cisplatin treatment.	Cisplatin	150-159	interleukin 1 beta	Mus musculus	90-98
20971730-11	2010	DSS colitic mice treated with the IL-1beta antibody as well as IL-1r(-/-) mice exhibited significantly blunted thrombogenic responses.	dss	0-3	interleukin 1 beta	Mus musculus	34-42
20828550-5	2010	Berberine inhibited colonic expression of iNOS, COX-2, IL-1beta, IL-6, and TNF-alpha, but increased IL-10 expression in the colons of TNBS-treated C3H/HeN and C3H/HeJ mice.	Berberine	0-9	interleukin 1 beta	Mus musculus	55-63
20817086-7	2010	Treatment with melatonin decreased the mRNA expression of TNF-alpha, IL-1beta, HO (HO-1 and HO-2), iNOS, MCP1, NFkappaB1, NFkappaB2 and NKAP in old male mice.	Melatonin	15-24	interleukin 1 beta	Mus musculus	69-77
20490462-9	2010	Th1 (IL-1beta and TNF-alpha) cytokines are underexpressed in majority of the airways tissues of silica-exposed mice.	Silicon Dioxide	96-102	interleukin 1 beta	Mus musculus	5-13
20813836-4	2010	In addition, C10 inhibits palmitate-induced IL6 and iNos up-regulation in both 3T3L1 adipocytes and RAW 264.7 macrophages, LPS-induced NF-kappaB and IFN-beta activation in 3T3L1 cells, and LPS-induced iNos, Ifn-beta, Il1beta, Cxcl10, and Il6 expression in RAW 264.7 macrophages.	Palmitates	26-35	interleukin 1 beta	Mus musculus	217-224
20956267-11	2010	IL-1beta, TNF-alpha, MMP-2 and MMP-9 mRNA levels were decreased in peritoneal cells of the SB203580 versus EM group (P &lt; 0.01, P &lt; 0.05, P &lt; 0.05 and P &lt; 0.05, respectively).	SB 203580	91-99	interleukin 1 beta	Mus musculus	0-8
20956267-12	2010	Concentrations of IL-1beta, TNF-alpha, MMP-2 and MMP-9 proteins in PF were reduced in the SB203580 versus EM group (P &lt; 0.05, P &lt; 0.01, P &lt; 0.05 and P &lt; 0.05, respectively).	SB 203580	90-98	interleukin 1 beta	Mus musculus	18-26
21030725-5	2010	After 16 months of exposure, the dorsal vagal complex (DVC) exhibited significant inflammation in endotoxin-treated and MC mice (COX-2 and IL-1beta P&lt;.001).	Methylcholanthrene	120-122	interleukin 1 beta	Mus musculus	139-147
20352482-4	2010	In vitro, norisoboldine substantially reduced the production of nitric oxide (NO), tumor necrosis factor (TNF)-alpha as well as interleukin (IL)-1beta from RAW264.7 macrophage cells in a concentration-dependent manner, whereas it only slightly reduced the production of interleukin-6 (IL-6) at both protein and transcription levels.	norisoboldine	10-23	interleukin 1 beta	Mus musculus	128-150
20933625-6	2010	Spinasterol also suppressed the production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) through extracellular signal-regulated kinase (ERK) pathway-dependent expression of HO-1.	spinasterol	0-11	interleukin 1 beta	Mus musculus	135-152
20933625-6	2010	Spinasterol also suppressed the production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) through extracellular signal-regulated kinase (ERK) pathway-dependent expression of HO-1.	spinasterol	0-11	interleukin 1 beta	Mus musculus	154-162
20804833-0	2010	Pro-IL-1beta accumulation in macrophages by alendronate and its prevention by clodronate.	Alendronate	44-55	interleukin 1 beta	Mus musculus	4-12
21437011-0	2010	Ivermectin-dependent release of IL-1beta in response to ATP by peritoneal macrophages from P2X(7)-KO mice.	Adenosine Triphosphate	56-59	interleukin 1 beta	Mus musculus	32-40
21437011-6	2010	One millimolar ATP increased the influx of extracellular calcium, decreased the intracellular concentration of potassium ([K(+)](i)) and stimulated the secretion of interleukin-1beta (IL-1beta) only in cells from WT mice.	Adenosine Triphosphate	15-18	interleukin 1 beta	Mus musculus	165-182
21437011-6	2010	One millimolar ATP increased the influx of extracellular calcium, decreased the intracellular concentration of potassium ([K(+)](i)) and stimulated the secretion of interleukin-1beta (IL-1beta) only in cells from WT mice.	Adenosine Triphosphate	15-18	interleukin 1 beta	Mus musculus	184-192
21437011-8	2010	The secretion of IL-1beta was also increased by nigericin in WT mice and the secretory effect of a combination of ivermectin with ATP in KO mice was suppressed in a medium containing a high concentration of potassium.	Nigericin	48-57	interleukin 1 beta	Mus musculus	17-25
21437011-8	2010	The secretion of IL-1beta was also increased by nigericin in WT mice and the secretory effect of a combination of ivermectin with ATP in KO mice was suppressed in a medium containing a high concentration of potassium.	Potassium	207-216	interleukin 1 beta	Mus musculus	17-25
20804833-2	2010	We previously reported that in mice: (i) a single intraperitoneal injection of alendronate (an NBP, 40 mumol/kg or less) induces various inflammatory reactions, (ii) these effects, which are minimal in IL-1-deficient mice, can be prevented by co-administration of clodronate (a non-NBP, 40 mumol/kg or less), and (iii) alendronate increases IL-1beta in tissues (liver, spleen, and lung), but strangely not in blood.	Alendronate	79-90	interleukin 1 beta	Mus musculus	341-349
20804833-5	2010	(b) Unlike LPS, alendronate induces minimal activation of caspase-1 (pro-IL-1beta-processing enzyme).	Alendronate	16-27	interleukin 1 beta	Mus musculus	73-81
20804833-7	2010	(d) In vitro, 100 muM alendronate directly stimulates RAW 264 cells (murine macrophage-like cells) to produce pro-IL-1beta, and 1 muM clodronate inhibits this effect.	Alendronate	22-33	interleukin 1 beta	Mus musculus	114-122
20804833-0	2010	Pro-IL-1beta accumulation in macrophages by alendronate and its prevention by clodronate.	Clodronic Acid	78-88	interleukin 1 beta	Mus musculus	4-12
20804833-7	2010	(d) In vitro, 100 muM alendronate directly stimulates RAW 264 cells (murine macrophage-like cells) to produce pro-IL-1beta, and 1 muM clodronate inhibits this effect.	Clodronic Acid	134-144	interleukin 1 beta	Mus musculus	114-122
20804833-8	2010	These results suggest that in mice: (i) the major pro-IL-1beta-producing cells in response to alendronate are macrophages, (ii) alendronate directly stimulates them to produce pro-IL-1beta, but the release of mature IL-1beta is below detectable levels due to insufficient activation of caspase-1, and (iii) clodronate inhibits the pro-IL-1beta production by acting directly on macrophages, although the in vivo mechanism may differ from the in vitro one.	Alendronate	94-105	interleukin 1 beta	Mus musculus	54-62
20645408-1	2010	We recently demonstrated that interleukin-1beta (IL-1beta) increases system x(c)(-) (cystine/glutamate antiporter) activity in mixed cortical cell cultures, resulting in an increase in hypoxic neuronal injury when glutamate clearance is impaired.	Glutamic Acid	93-102	interleukin 1 beta	Mus musculus	30-47
20804833-8	2010	These results suggest that in mice: (i) the major pro-IL-1beta-producing cells in response to alendronate are macrophages, (ii) alendronate directly stimulates them to produce pro-IL-1beta, but the release of mature IL-1beta is below detectable levels due to insufficient activation of caspase-1, and (iii) clodronate inhibits the pro-IL-1beta production by acting directly on macrophages, although the in vivo mechanism may differ from the in vitro one.	Alendronate	128-139	interleukin 1 beta	Mus musculus	180-188
20804833-8	2010	These results suggest that in mice: (i) the major pro-IL-1beta-producing cells in response to alendronate are macrophages, (ii) alendronate directly stimulates them to produce pro-IL-1beta, but the release of mature IL-1beta is below detectable levels due to insufficient activation of caspase-1, and (iii) clodronate inhibits the pro-IL-1beta production by acting directly on macrophages, although the in vivo mechanism may differ from the in vitro one.	Alendronate	128-139	interleukin 1 beta	Mus musculus	180-188
20804833-8	2010	These results suggest that in mice: (i) the major pro-IL-1beta-producing cells in response to alendronate are macrophages, (ii) alendronate directly stimulates them to produce pro-IL-1beta, but the release of mature IL-1beta is below detectable levels due to insufficient activation of caspase-1, and (iii) clodronate inhibits the pro-IL-1beta production by acting directly on macrophages, although the in vivo mechanism may differ from the in vitro one.	Alendronate	128-139	interleukin 1 beta	Mus musculus	180-188
20816729-8	2010	Expression of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and chemokine (MIP-1alpha) in lung showed an increase from 1h to 24h after instillation and recovered thereafter.	Hydrogen	132-134	interleukin 1 beta	Mus musculus	42-50
21059855-6	2010	Whereas pretreatment of wild-type mice with P2X(7) antagonists, the ATP-degrading enzyme apyrase or IL-1 receptor antagonist, prevents CHS, IL-1beta injection restores CHS in P2X(7)-deficient mice.	Adenosine Triphosphate	68-71	interleukin 1 beta	Mus musculus	140-148
20645408-5	2010	The increase in cystine uptake that follows IL-1beta is lacking in astrocytes derived from mice harboring a mutation in Slc7a11 (sut gene), which encodes for xCT, and in wild-type astrocytes treated with the protein synthesis inhibitor cycloheximide.	Cycloheximide	236-249	interleukin 1 beta	Mus musculus	44-52
20645408-1	2010	We recently demonstrated that interleukin-1beta (IL-1beta) increases system x(c)(-) (cystine/glutamate antiporter) activity in mixed cortical cell cultures, resulting in an increase in hypoxic neuronal injury when glutamate clearance is impaired.	Glutamic Acid	93-102	interleukin 1 beta	Mus musculus	49-57
20645408-3	2010	However, IL-1beta stimulation increases mRNA for xCT--the light chain that confers substrate specificity--in astrocytes only; an effect blocked by the transcriptional inhibitor actinomycin D.	Dactinomycin	177-190	interleukin 1 beta	Mus musculus	9-17
20645408-4	2010	Additionally, only astrocytes show an increase in cystine uptake following IL-1beta exposure; an effect associated with a change in xCT protein.	Cystine	50-57	interleukin 1 beta	Mus musculus	75-83
20645408-5	2010	The increase in cystine uptake that follows IL-1beta is lacking in astrocytes derived from mice harboring a mutation in Slc7a11 (sut gene), which encodes for xCT, and in wild-type astrocytes treated with the protein synthesis inhibitor cycloheximide.	Cystine	16-23	interleukin 1 beta	Mus musculus	44-52
20645408-5	2010	The increase in cystine uptake that follows IL-1beta is lacking in astrocytes derived from mice harboring a mutation in Slc7a11 (sut gene), which encodes for xCT, and in wild-type astrocytes treated with the protein synthesis inhibitor cycloheximide.	SUT	129-132	interleukin 1 beta	Mus musculus	44-52
20943996-5	2010	IL-1beta-induced PGE(2) synthesis was dramatically reduced in mPGES-1(-/-) and mPGES-1(+/-) compared with mPGES-1(+/+) chondrocytes.	Prostaglandins E	17-20	interleukin 1 beta	Mus musculus	0-8
20943996-7	2010	IL-1beta-induced MMP-3 and MMP-13 mRNA expression, protein expression, and release decreased in mPGES-1(-/-) and mPGES-1(+/-) chondrocytes compared with mPGES-1(+/+) chondrocytes from 8 up to 24 h. Otherwise, MMP inhibition was partially reversed by addition of 10 ng/ml PGE(2) in mPGES-1(-/-) chondrocytes.	Prostaglandins E	97-100	interleukin 1 beta	Mus musculus	0-8
20823108-5	2010	Treatment with honokiol significantly inhibited UVB-induced expression of cyclooxygenase-2, prostaglandin E(2) (P &lt; 0.001), proliferating cell nuclear antigen and proinflammatory cytokines, such as tumor necrosis factor-alpha (P &lt; 0.001), interleukin (IL)-1beta (P &lt; 0.01) and IL-6 (P &lt; 0.001) in the skin as well as in skin tumors.	honokiol	15-23	interleukin 1 beta	Mus musculus	245-267
20662061-0	2010	Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1beta production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis.	Fatty Acids	14-25	interleukin 1 beta	Mus musculus	59-76
20662061-0	2010	Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1beta production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis.	Uric Acid	121-149	interleukin 1 beta	Mus musculus	59-76
20667461-4	2010	In our study phloroglucinol exhibited inhibitory effects not only on oxidative stress but also on the production of inflammatory mediators such as tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and prostaglandin E(2) in RAW264.7 cells stimulated by lipopolysaccharide.	Phloroglucinol	13-27	interleukin 1 beta	Mus musculus	176-193
20979661-0	2010	Z-360, a novel therapeutic agent for pancreatic cancer, prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 beta production in a cancer-induced pain model in mice.	Z-360	0-5	interleukin 1 beta	Mus musculus	155-173
20979661-7	2010	In addition, IL-1beta production increased in the cancer-inoculated hind paw of mice, but could be suppressed by treatment with Z-360.	Z-360	128-133	interleukin 1 beta	Mus musculus	13-21
20979661-8	2010	Moreover, we observed that the CCK1 receptor antagonist devazepide similarly suppressed up-regulation of ephrin B1 gene expression and IL-1beta production, and that the intraperitoneal injection of sulfated CCK-8 induced the production of IL-1beta in the cancer-inoculated region.	Devazepide	56-66	interleukin 1 beta	Mus musculus	135-143
20979661-8	2010	Moreover, we observed that the CCK1 receptor antagonist devazepide similarly suppressed up-regulation of ephrin B1 gene expression and IL-1beta production, and that the intraperitoneal injection of sulfated CCK-8 induced the production of IL-1beta in the cancer-inoculated region.	Devazepide	56-66	interleukin 1 beta	Mus musculus	239-247
20979661-9	2010	CONCLUSIONS: We have identified a novel pain cascade, in which IL-1beta production in cancer-inoculated regions induces ephrin B1 gene expression in DRGs and then ephrin B1 enhances the tyrosine phosphorylation of NR2B via Eph B receptor in the spinal cord.	Tyrosine	186-194	interleukin 1 beta	Mus musculus	63-71
20979661-10	2010	Notably, Z-360 relieves cancer-induced pain by preventing this pain cascade through the suppression of IL-1beta production, likely via the blockade of CCK1 receptor.	Z-360	9-14	interleukin 1 beta	Mus musculus	103-111
20655115-4	2010	Resveratrol suppressed expressions of IL-1beta and TNF-alpha, microglial activation, and ROS production in the ischemic cortex.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	38-46
20920345-9	2010	Carrageenin-induced TNF-alpha and CXCL1/KC production and neutrophil recruitment in the paws of WT mice were not different from casp1-/- mice, while the maturation of IL-1beta was reduced in casp1-/- mice.	Carrageenan	0-11	interleukin 1 beta	Mus musculus	167-175
20707612-5	2010	An in vivo study on the 7 day action of TCDD on liver of AhR(NLS) mice showed that several early markers (e.g., Cox-2, MCP-1 and SOCS3) are induced, but not late markers such as IL-1beta.	Polychlorinated Dibenzodioxins	40-44	interleukin 1 beta	Mus musculus	178-186
20133359-7	2010	Furthermore, the results also showed that UA significantly reduced the number of activated microglia cells and astrocytes, decreased the expression of CD11b and glial fibrillary acidic protein, downregulated the expression of iNOS and COX-2, and decreased interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha levels in the prefrontal cortex of D-gal-treated mice.	ursolic acid	42-44	interleukin 1 beta	Mus musculus	256-278
20837171-7	2010	The elevated TNF-alpha, IL-1beta and iNOS mRNA expression in tissue were down-regulated after treatment with SKLB010.	5-(4-methoxybenzylidene)thiazolidine-2,4-dione	109-116	interleukin 1 beta	Mus musculus	24-32
20452289-15	2010	(-)-Linalool inhibited the biting response induced by IL-1beta and TNF-alpha.	linalool	0-12	interleukin 1 beta	Mus musculus	54-62
20923188-3	2010	Soyasaponin I, which exhibited lipid peroxidation-inhibitory effects in vitro, inhibited the production of proinflammatory cytokines (TNF-alpha and IL-1beta), inflammatory mediators (NO and PGE2), and inflammatory enzymes (COX-2 and iNOS) in LPS-stimulated peritoneal macrophages.	soyasaponin I	0-13	interleukin 1 beta	Mus musculus	148-156
22419922-9	2010	STZ-exposed mice showed a significant increase in pancreatic TBARS, MPO, IL-1beta, and TNF-alpha levels, along with a significant decrease in FRAP value.	Streptozocin	0-3	interleukin 1 beta	Mus musculus	73-81
19939906-3	2010	Sesamol also down-regulated TNF-alpha, IL-1beta, and nitrite production as well as inducible nitric oxide synthase expression in LPS-treated RAW 264.7 cells.	sesamol	0-7	interleukin 1 beta	Mus musculus	39-47
19939906-2	2010	Sesamol inhibited serum tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and nitrite production in LPS-treated mice, and inhibited LPS-induced inducible nitric oxide synthase expression in mouse leukocytes.	sesamol	0-7	interleukin 1 beta	Mus musculus	59-81
20731354-4	2010	Topical application of TPA to ears of CD-1 mice induced inflammation accompanied with substantial increase in TNF-alpha, IL-1beta, IL-6, LTB4, and PGE2 levels and an elevation in intercellular adhesion molecule-1 (ICAM-1) gene expressions in ear skin tissues.	Tetradecanoylphorbol Acetate	23-26	interleukin 1 beta	Mus musculus	121-129
20418177-11	2010	Our findings show that GL inhibits acute and neuropathic pain in mice through mechanisms that involve the inhibition of ionotropic glutamate receptors and the interleukin -1beta pathway.	beta-Glucans	23-25	interleukin 1 beta	Mus musculus	159-177
20418177-12	2010	PERSPECTIVE: This article presents the antinociceptive activity of GL in acute and neuropathic pain with participation of ionotropic glutamate receptors and pro-inflammatory cytokines (interleukin-1beta).	beta-Glucans	67-69	interleukin 1 beta	Mus musculus	185-202
20633530-4	2010	Glabridin decreased the functional maturation of DCs, in that glabridin attenuated pro-inflammatory cytokine production of IL-12, IL-1beta, TNF-alpha, and IFN-alpha/beta, enhanced antigen capture capacity, inhibited migration to SDF-1alpha and MIP-3beta, and impaired induction of allogenic T cell activation.	glabridin	0-9	interleukin 1 beta	Mus musculus	130-138
20633530-4	2010	Glabridin decreased the functional maturation of DCs, in that glabridin attenuated pro-inflammatory cytokine production of IL-12, IL-1beta, TNF-alpha, and IFN-alpha/beta, enhanced antigen capture capacity, inhibited migration to SDF-1alpha and MIP-3beta, and impaired induction of allogenic T cell activation.	glabridin	62-71	interleukin 1 beta	Mus musculus	130-138
20333481-10	2010	The levels of proinflammatory cytokines (interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha) in the SN were also decreased and induced by MPTP.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	154-158	interleukin 1 beta	Mus musculus	41-59
21165322-7	2010	KA-induced gliosis and proinflammatory marker (IL-1beta, TNF-alpha, IL-6, and COX-2) inductions were also suppressed by visnagin administration.	visnagin	120-128	interleukin 1 beta	Mus musculus	47-55
20637792-0	2010	Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury.	Acetaminophen	43-56	interleukin 1 beta	Mus musculus	22-39
20886104-8	2010	The effects of TcpC on bacterial persistence were attenuated in Trif (-/-) or Il-1beta (-/-) mice and innate immune responses to DeltaTcpC were increased, confirming that Trif and Il-1beta dependent targets might be involved in vivo, in addition to Myd88.	tcpc	15-19	interleukin 1 beta	Mus musculus	78-86
20886104-8	2010	The effects of TcpC on bacterial persistence were attenuated in Trif (-/-) or Il-1beta (-/-) mice and innate immune responses to DeltaTcpC were increased, confirming that Trif and Il-1beta dependent targets might be involved in vivo, in addition to Myd88.	tcpc	15-19	interleukin 1 beta	Mus musculus	180-188
20522787-8	2010	Modulation of eATP levels with the ATP-degrading enzyme apyrase greatly reduced BLM-induced inflammatory cell recruitment, lung IL-1beta, and tissue inhibitor of metalloproteinase (TIMP)-1 production, while administration of ATP-gammaS, a stable ATP derivative, enhanced inflammation.	Adenosine Triphosphate	15-18	interleukin 1 beta	Mus musculus	128-136
20522787-8	2010	Modulation of eATP levels with the ATP-degrading enzyme apyrase greatly reduced BLM-induced inflammatory cell recruitment, lung IL-1beta, and tissue inhibitor of metalloproteinase (TIMP)-1 production, while administration of ATP-gammaS, a stable ATP derivative, enhanced inflammation.	Adenosine Triphosphate	35-38	interleukin 1 beta	Mus musculus	128-136
20522787-12	2010	CONCLUSIONS: ATP released from BLM-injured lung cells constitutes a major endogenous danger signal that engages the P2X(7) receptor/pannexin-1 axis, leading to IL-1beta maturation and lung fibrosis.	Adenosine Triphosphate	13-16	interleukin 1 beta	Mus musculus	160-168
20550948-7	2010	Northern blot analyses and immunohistochemistry of colonic tissue revealed that C10 markedly diminished DSS-induced expression of pertinent inflammatory mediators: TNF-alpha, IL-1beta, IL-6, IL-12, IP-10, TLR-4 and VCAM-1.	Dextran Sulfate	104-107	interleukin 1 beta	Mus musculus	175-183
20637792-9	2010	To evaluate the potential of IL-1beta to increase injury, mice were given pharmacological doses of IL-1beta after APAP overdose.	Acetaminophen	114-118	interleukin 1 beta	Mus musculus	99-107
20637792-11	2010	We conclude that endogenous IL-1beta formation after APAP overdose is insufficient to activate and recruit neutrophils into the liver or cause liver injury.	Acetaminophen	53-57	interleukin 1 beta	Mus musculus	28-36
20534383-5	2010	In addition, LPS-induced pro-inflammatory cytokines, including IL-1beta, IL-6, and TNF-alpha, were also decreased by pretreatment with isodojaponin D. This effect was accompanied by a decrease in translocations of Nuclear Factor-KappaB (NF-kappaB) p50 and p65 from the cytoplasm to the nucleus and by a decrease in I kappaB (IkappaB) degradation.	isodojaponin	135-147	interleukin 1 beta	Mus musculus	63-71
20684827-9	2010	In addition, aortic expression of proatherogenic molecules including TNF-alpha, IL-1beta, IL-6, MCP-1 and VCAM-1, was lower in the BHB-TZD group than the control group.	3-Hydroxybutyric Acid	131-134	interleukin 1 beta	Mus musculus	80-88
20684827-9	2010	In addition, aortic expression of proatherogenic molecules including TNF-alpha, IL-1beta, IL-6, MCP-1 and VCAM-1, was lower in the BHB-TZD group than the control group.	tzd	135-138	interleukin 1 beta	Mus musculus	80-88
20609401-2	2010	In a cellular model of inflammation, DMC inhibited production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) and attenuated expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), IL-1 beta, inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2).	methyl carbonate	37-40	interleukin 1 beta	Mus musculus	207-216
20442201-4	2010	METHODS: IL-1beta production in response to DSS was studied in macrophages of wild-type, caspase-1(-/-), NLRP3(-/-), ASC(-/-), cathepsin B(-/-) or cathepsin L(-/-) mice.	Dextran Sulfate	44-47	interleukin 1 beta	Mus musculus	9-17
20442201-8	2010	RESULTS: Macrophages incubated with DSS in vitro secreted high levels of IL-1beta in a caspase-1-dependent manner.	Dextran Sulfate	36-39	interleukin 1 beta	Mus musculus	73-81
20442201-9	2010	IL-1beta secretion was abrogated in macrophages lacking NLRP3, ASC or caspase-1, indicating that DSS activates caspase-1 via the NLRP3 inflammasome.	Dextran Sulfate	97-100	interleukin 1 beta	Mus musculus	0-8
20442201-10	2010	Moreover, IL-1beta secretion was dependent on phagocytosis, lysosomal maturation, cathepsin B and L, and reactive oxygen species (ROS).	Reactive Oxygen Species	105-128	interleukin 1 beta	Mus musculus	10-18
20442201-10	2010	Moreover, IL-1beta secretion was dependent on phagocytosis, lysosomal maturation, cathepsin B and L, and reactive oxygen species (ROS).	Reactive Oxygen Species	130-133	interleukin 1 beta	Mus musculus	10-18
20952738-6	2010	The addition of itraconazoles to LPS-stimulated RAW264.7 cells significantly reduced the production of NO, but rather enhanced the production of PGE2, TNF-alpha and IL-1beta.	Itraconazole	16-29	interleukin 1 beta	Mus musculus	165-173
20609401-5	2010	of DMC (1-50mg/kg) suppressed TNF-alpha, IL-6 and IL-1 beta secretion in LPS-induced mouse blood serum.	methyl carbonate	3-6	interleukin 1 beta	Mus musculus	50-59
20882700-8	2010	Further immunohistochemical analysis and cytokine determination revealed that Fasudil inhibited inducible nitric oxide synthase immunoreactivity in microglia and pro-inflammatory factors in brain tissue after H/R, which is consistent with the observation wherein Fasudil reduced the pro-inflammatory factors nitric oxide, IL-1beta, IL-6 and TNF-, and increased anti-inflammatory factor IL-10 in cultured microglia under normoxic or hypoxic conditions.	fasudil	78-85	interleukin 1 beta	Mus musculus	322-330
20920427-3	2010	For the present studies, we utilized these transgenic mice to determine the role of IL-1B in glucose sensor function in vivo.	Glucose	93-100	interleukin 1 beta	Mus musculus	84-89
20712904-8	2010	Resveratrol inhibited LPS-induced expression and release of TNF-alpha, IL-6, MCP-1, and iNOS/NO in both cell types with more potency in microglia, and inhibited LPS-induced expression of IL-1beta in microglia but not astrocytes.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	187-195
20609517-8	2010	Ongoing hyperalgesia in GRK2(+/-) mice is reversed by minocycline administration at days 1 and 2 after IL-1beta injection.	Minocycline	54-65	interleukin 1 beta	Mus musculus	103-111
20609517-9	2010	Similarly, IL-1beta-induced hyperalgesia in LysM-GRK2(f/+) mice is attenuated by intrathecal administration of anti-CX3CR1 to abrogate fractalkine signaling, the p38 inhibitor SB239063 and the IL-1 antagonist IL-1ra.	SB 239063	176-184	interleukin 1 beta	Mus musculus	11-19
21061575-7	2010	Fucoidanes stimulate DC to produce proinflammatory (TNF-alpha, IL-6, IL-1beta) and regulatory (IL-12) cytokines.	fucoidanes	0-10	interleukin 1 beta	Mus musculus	69-77
20649584-5	2010	KEY RESULTS: Cucurbitacin R was found to induce apoptosis in lipopolysaccharide-stimulated RAW 264.7 macrophages through the inhibition of Bcl-2 expression, which regulates pro-inflammatory caspase-1 activation and interleukin-1beta release.	cucurbitacin R	13-27	interleukin 1 beta	Mus musculus	215-232
20639492-4	2010	In this study, we examined P2X(7)R function in resting human lung macrophages and mouse bone marrow-derived macrophages and found that ATP induced rapid release of the lysosomal cysteine proteases cathepsin B, K, L, and S and that was independent of the presence of the proinflammatory cytokines IL-1beta and IL-18.	Adenosine Triphosphate	135-138	interleukin 1 beta	Mus musculus	296-304
20730378-3	2010	We demonstrate here that dofetilide (DOF), a selective inhibitor of the Kv11.1 current, had a profound inhibitory effect on neutrophil recruitment in mice following TLR/IL-1R-elicited peritonitis or intrascrotal injection of IL-1 Beta, but had no effect on responses seen with TNF alpha.	dofetilide	25-35	interleukin 1 beta	Mus musculus	225-234
20730378-3	2010	We demonstrate here that dofetilide (DOF), a selective inhibitor of the Kv11.1 current, had a profound inhibitory effect on neutrophil recruitment in mice following TLR/IL-1R-elicited peritonitis or intrascrotal injection of IL-1 Beta, but had no effect on responses seen with TNF alpha.	dofetilide	37-40	interleukin 1 beta	Mus musculus	225-234
20649584-8	2010	Finally, the transfection of RAW 264.7 macrophages with a Bcl-2 expression plasmid produced the inhibition of apoptosis and caspase-1 activation/interleukin-1beta release induced by cucurbitacin R in RAW 264.7 cells.	cucurbitacin R	182-196	interleukin 1 beta	Mus musculus	145-162
20546946-4	2010	Sulfuretin dose-dependently reduced the productions of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1 beta) induced by LPS.	sulfuretin	0-10	interleukin 1 beta	Mus musculus	148-166
20398664-4	2010	In the present study, we hypothesize that TcdA and TcdB trigger inflammasome-dependent interleukin (IL)-1beta production, which contributes to the pathogenesis of CDAD.	tcda	42-46	interleukin 1 beta	Mus musculus	87-109
20398664-4	2010	In the present study, we hypothesize that TcdA and TcdB trigger inflammasome-dependent interleukin (IL)-1beta production, which contributes to the pathogenesis of CDAD.	trimethylaminocarboxyldihydroboran	51-55	interleukin 1 beta	Mus musculus	87-109
20398664-4	2010	In the present study, we hypothesize that TcdA and TcdB trigger inflammasome-dependent interleukin (IL)-1beta production, which contributes to the pathogenesis of CDAD.	cdad	163-167	interleukin 1 beta	Mus musculus	87-109
20398664-11	2010	TcdB-induced IL-1beta release required recognition of the full-length toxin but not its enzymatic function.	trimethylaminocarboxyldihydroboran	0-4	interleukin 1 beta	Mus musculus	13-21
20398664-13	2010	CONCLUSIONS: TcdA and TcdB trigger IL-1beta release by activating an ASC-containing inflammasome, a response that contributes to toxin-induced inflammation and damage in vivo.	tcda	13-17	interleukin 1 beta	Mus musculus	35-43
20398664-13	2010	CONCLUSIONS: TcdA and TcdB trigger IL-1beta release by activating an ASC-containing inflammasome, a response that contributes to toxin-induced inflammation and damage in vivo.	trimethylaminocarboxyldihydroboran	22-26	interleukin 1 beta	Mus musculus	35-43
20546946-5	2010	Consistent with these findings, sulfuretin significantly suppressed the LPS-induced expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), TNF-alpha, and IL-1 beta.	sulfuretin	32-42	interleukin 1 beta	Mus musculus	180-189
20113347-6	2010	Topical application of 10 micromol/l ellagic acid diminished production of pro-inflammatory cytokines IL-1beta and IL-6, and blocked infiltration of inflammatory macrophages in the integuments of SKH-1 hairless mice exposed to UV-B for 8 weeks.	Ellagic Acid	37-49	interleukin 1 beta	Mus musculus	102-110
20544860-4	2010	In Foxp3 mutant mice (Foxp3(sf)), microglia release higher levels of inflammatory cytokines and mediators such as NO, MCP-1, CXCL10, and ROS upon liposaccharide treatment than the wild type, while TNF-alpha and IL-1 beta were not significantly different between wild and mutant microglial cells.	liposaccharide	146-160	interleukin 1 beta	Mus musculus	211-220
20546946-4	2010	Sulfuretin dose-dependently reduced the productions of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1 beta) induced by LPS.	sulfuretin	0-10	interleukin 1 beta	Mus musculus	168-177
20508080-2	2010	To test the acute effects of the inflammatory cytokines interleukin 1 beta (IL1 beta) and tumor necrosis factor alpha (TNFalpha) on Zn homeostasis, the mRNA expression profile of Zn transporters of the ZnT and ZIP families was examined.	Zinc	132-134	interleukin 1 beta	Mus musculus	76-84
20508080-6	2010	The labile Zn content determined by flow cytometry after loading with the Zn-specific sensor FluoZin-3 AM was decreased in MIN6 cells following ZnT8 knockdown or IL1 beta treatment.	Zinc	11-13	interleukin 1 beta	Mus musculus	162-170
20508080-6	2010	The labile Zn content determined by flow cytometry after loading with the Zn-specific sensor FluoZin-3 AM was decreased in MIN6 cells following ZnT8 knockdown or IL1 beta treatment.	Zinc	74-76	interleukin 1 beta	Mus musculus	162-170
20508080-6	2010	The labile Zn content determined by flow cytometry after loading with the Zn-specific sensor FluoZin-3 AM was decreased in MIN6 cells following ZnT8 knockdown or IL1 beta treatment.	fluozin	93-100	interleukin 1 beta	Mus musculus	162-170
20508080-6	2010	The labile Zn content determined by flow cytometry after loading with the Zn-specific sensor FluoZin-3 AM was decreased in MIN6 cells following ZnT8 knockdown or IL1 beta treatment.	3 am	101-105	interleukin 1 beta	Mus musculus	162-170
20349038-10	2010	Moreover, olprinone decreased NF-kappaB expression; the nitration of tyrosine residues; the phosphorylation of p38 MAPK and JNK; cytokine production (TNF-alpha and IL-1beta); ICAM-1 and P-selectin expression and apoptosis in the injured ileum.	olprinone	10-19	interleukin 1 beta	Mus musculus	164-172
20412841-5	2010	The treatment of HFD with BaP enhanced the expression of IL-1beta in the liver and TNFalpha throughout the bowel and in the liver.	Benzo(a)pyrene	26-29	interleukin 1 beta	Mus musculus	57-65
20673058-6	2010	The chloroform fraction significantly suppressed production of NO, PGE(2), and two pro-inflammatory cytokines (TNF-alpha and IL-1beta) in a dose-dependent manner with 50% inhibitory concentration values of 66.51, 90.96, 114.76, and 171.06 microg/mL, respectively.	Chloroform	4-14	interleukin 1 beta	Mus musculus	125-133
20006347-7	2010	RESULTS: PS-341 significantly inhibited NF-kappaB activation, while the pancreatic cell apoptosis was significantly enhanced, resulting in the improved parameters such as serum amylase, C-reactive protein, lactate dehydrogenase, interleukin-1beta, interleukin-6, and pancreatic myeloperoxidase activity.	Bortezomib	9-15	interleukin 1 beta	Mus musculus	229-246
20378317-3	2010	We also show that atrovirinone inhibits the secretion of IL-1beta and IL-6 in a dose dependent fashion whereas the secretion of IL-10, the anti-inflammatory cytokine, was enhanced.	atrovirinone	18-30	interleukin 1 beta	Mus musculus	57-65
21090324-7	2010	Comparison between AM and N-AM groups showed that the expression levels of cortical IL-1beta mRNA and IL-2 mRNA, and IL-1beta and IL-2 proteins of the former group were obviously higher than those of the later group (P &lt; 0.05, P &lt; 0.01); while the immunoactivity of cortical IL-6 of AM group was significantly lower than that of N-AM group (P &lt; 0.05).	n-am	26-30	interleukin 1 beta	Mus musculus	84-92
21090324-7	2010	Comparison between AM and N-AM groups showed that the expression levels of cortical IL-1beta mRNA and IL-2 mRNA, and IL-1beta and IL-2 proteins of the former group were obviously higher than those of the later group (P &lt; 0.05, P &lt; 0.01); while the immunoactivity of cortical IL-6 of AM group was significantly lower than that of N-AM group (P &lt; 0.05).	n-am	26-30	interleukin 1 beta	Mus musculus	117-125
20554954-3	2010	We show in this study that chronic E2 administration to ovariectomized mice significantly increased both cytokine (IL-1beta, IL-6, and TNF-alpha) and inducible NO synthase mRNA abundance in thioglycolate (TGC)-elicited macrophages.	Thioglycolates	190-203	interleukin 1 beta	Mus musculus	115-123
20566832-5	2010	This neuroprotection afforded by paroxetine was associated with the suppression of astroglial myeloperoxidase expression and/or NADPH oxidase-derived reactive oxygen species production and reduced expression of proinflammatory cytokines, including IL-1beta, TNF-alpha, and inducible NO synthase, by activated microglia.	Paroxetine	33-43	interleukin 1 beta	Mus musculus	248-256
20347815-9	2010	After a single oral dose of MNU, interleukin (IL)-1alpha was up-regulated significantly in control mice compared with Ikkbeta(DeltaST) mice, whereas the levels of IL-1beta, IL-6, and tumor necrosis factor-alpha were unchanged.	Methylnitrosourea	28-31	interleukin 1 beta	Mus musculus	163-171
20347818-10	2010	Kupffer cells produced IL-1beta in response to CpG oligodeoxynucleotide.	Oligodeoxyribonucleotides	51-71	interleukin 1 beta	Mus musculus	23-31
20412387-2	2010	Downstream actions of IL-1beta include production of prostaglandin (PG) E(2) by increasing expression of cyclooxygenase (COX) enzymes and prostaglandin E synthase (PGES) isoforms.	Dinoprostone	53-76	interleukin 1 beta	Mus musculus	22-30
20412387-5	2010	Here, we aimed to elucidate the effects of long-term IL-1beta expression on the PGE(2) synthetic pathway and to determine the effects of PGs on inflammation and memory in our model.	Dinoprostone	80-86	interleukin 1 beta	Mus musculus	53-61
20412387-6	2010	As expected, PGE(2) levels were significantly elevated after IL-1beta up-regulation.	Dinoprostone	13-19	interleukin 1 beta	Mus musculus	61-69
20412387-9	2010	Furthermore, pharmacological inhibition of COX-1 and use of COX-1 knockout mice abrogated IL-1beta-mediated PGE(2) increases.	Prostaglandins E	108-111	interleukin 1 beta	Mus musculus	90-98
20178133-8	2010	RESULTS: Aurothiomalate inhibited IL-1beta-induced COX-2 expression and prostaglandin E(2) production by destabilizing COX-2 mRNA, as did the p38 MAPK inhibitor SB203580.	SB 203580	161-169	interleukin 1 beta	Mus musculus	34-42
20375198-10	2010	Finally, URB597 attenuated levels of the proinflammatory cytokines interleukin-1beta and tumor necrosis factor alpha in LPS-treated paws.	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester	9-15	interleukin 1 beta	Mus musculus	67-116
20617171-8	2010	In conclusion, these data are consistent with a model in which beta-glucan on A.fumigatus germinating conidia activates Dectin-1 on corneal macrophages to produce IL-1beta, and CXCL1, which together with IL-1R1/MyD88-dependent activation, results in recruitment of neutrophils to the corneal stroma and TLR4-dependent fungal killing.	beta-Glucans	63-74	interleukin 1 beta	Mus musculus	163-171
20178133-8	2010	RESULTS: Aurothiomalate inhibited IL-1beta-induced COX-2 expression and prostaglandin E(2) production by destabilizing COX-2 mRNA, as did the p38 MAPK inhibitor SB203580.	Gold Sodium Thiomalate	9-23	interleukin 1 beta	Mus musculus	34-42
20201075-8	2010	META060 inhibited osteoclastogenesis, as indicated by decreased transformation of RAW 264.7 cells to osteoclasts and reduced TRAP activity, and inhibited IL-1beta-activated prostaglandin E(2), matrix metalloproteinase 3, IL-6, IL-8, and monocyte chemotactic protein 1 in RASFs.	Prostaglandins E	173-188	interleukin 1 beta	Mus musculus	154-162
20100502-7	2010	In wild-type mice, acetaminophen increased mRNA expression of the pro-inflammatory cytokines, interleukin-1beta, and monocyte chemoattractant protein-1 (MCP-1), as well as cyclooxygenase-2, while 15-lipoxygenase (15-LOX), which generates anti-inflammatory lipoxins, decreased.	Acetaminophen	19-32	interleukin 1 beta	Mus musculus	94-111
19708075-7	2010	Significantly higher gene expressions of the proinflammatory cytokines, TNF-alpha and Il-1beta, were found in macrophages seeded onto PEG compared to PEG-RGD and silicone at 1 and 2 days.	Polyethylene Glycols	134-137	interleukin 1 beta	Mus musculus	86-94
20512929-7	2010	In addition, berberine effectively inhibited proinflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 expression.	Berberine	13-22	interleukin 1 beta	Mus musculus	90-98
20147964-5	2010	Striking increases in DsRed signal were observed after topical application of a contact sensitizer, oxazolone, which also induced markedly elevated IL-1beta mRNA and protein expression.	Oxazolone	100-109	interleukin 1 beta	Mus musculus	148-156
20862209-5	2010	Release of IL-1beta from macrophages was suppressed by the reactive oxygen species (ROS) scavenger N-acetyl cysteine (NAC) and high extracellular K(+), which are two agents known to inhibit NALP3/cryopyrin/CIAS1 inflammasome formation.	Reactive Oxygen Species	59-82	interleukin 1 beta	Mus musculus	11-19
20862209-5	2010	Release of IL-1beta from macrophages was suppressed by the reactive oxygen species (ROS) scavenger N-acetyl cysteine (NAC) and high extracellular K(+), which are two agents known to inhibit NALP3/cryopyrin/CIAS1 inflammasome formation.	Reactive Oxygen Species	84-87	interleukin 1 beta	Mus musculus	11-19
20862209-5	2010	Release of IL-1beta from macrophages was suppressed by the reactive oxygen species (ROS) scavenger N-acetyl cysteine (NAC) and high extracellular K(+), which are two agents known to inhibit NALP3/cryopyrin/CIAS1 inflammasome formation.	Acetylcysteine	99-116	interleukin 1 beta	Mus musculus	11-19
20862209-5	2010	Release of IL-1beta from macrophages was suppressed by the reactive oxygen species (ROS) scavenger N-acetyl cysteine (NAC) and high extracellular K(+), which are two agents known to inhibit NALP3/cryopyrin/CIAS1 inflammasome formation.	Acetylcysteine	118-121	interleukin 1 beta	Mus musculus	11-19
20862209-7	2010	In contrast, proteasomal inhibitors bortezomib and MG-132 completely suppressed ricin-induced IL-1beta release from macrophages.	Bortezomib	36-46	interleukin 1 beta	Mus musculus	94-102
20862209-7	2010	In contrast, proteasomal inhibitors bortezomib and MG-132 completely suppressed ricin-induced IL-1beta release from macrophages.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	51-57	interleukin 1 beta	Mus musculus	94-102
20332197-0	2010	XOMA 052, an anti-IL-1{beta} monoclonal antibody, improves glucose control and {beta}-cell function in the diet-induced obesity mouse model.	Glucose	59-66	interleukin 1 beta	Mus musculus	18-27
20332197-2	2010	Although previous work has shown that inhibiting IL-1beta can lead to improvements in glucose control and beta-cell function, we hypothesized that more efficient targeting of IL-1beta with a novel monoclonal antibody, XOMA 052, would reveal an effect on additional parameters affecting metabolic disease.	Glucose	86-93	interleukin 1 beta	Mus musculus	49-57
20169455-9	2010	DBZ treatment suppressed the mRNA levels for interleukin-1beta and -6, and matrix metalloproteinases-3 and -9 in the DSS-treated intestine.	dibenzazepine	0-3	interleukin 1 beta	Mus musculus	45-109
20169455-9	2010	DBZ treatment suppressed the mRNA levels for interleukin-1beta and -6, and matrix metalloproteinases-3 and -9 in the DSS-treated intestine.	Dextran Sulfate	117-120	interleukin 1 beta	Mus musculus	45-109
20448200-9	2010	Moreover, vinpocetine potently inhibits TNF-alpha- or LPS-induced up-regulation of proinflammatory mediators, including TNF-alpha, IL-1beta, and macrophage inflammatory protein-2, and decreases interstitial infiltration of polymorphonuclear leukocytes in a mouse model of TNF-alpha- or LPS-induced lung inflammation.	vinpocetine	10-21	interleukin 1 beta	Mus musculus	131-139
20025057-5	2010	However, in cells treated with LPS coupled with COX-2 neutralization, the mRNA expression levels of COX-2, mPGES-1, tumor necrosis factor-alpha, interleukin-1beta and inducible nitric oxide synthase were significantly suppressed; production of prostaglandin E(2) and reactive oxygen species also decreased.	Dinoprostone	244-262	interleukin 1 beta	Mus musculus	145-162
20025057-5	2010	However, in cells treated with LPS coupled with COX-2 neutralization, the mRNA expression levels of COX-2, mPGES-1, tumor necrosis factor-alpha, interleukin-1beta and inducible nitric oxide synthase were significantly suppressed; production of prostaglandin E(2) and reactive oxygen species also decreased.	Reactive Oxygen Species	267-290	interleukin 1 beta	Mus musculus	145-162
20201036-5	2010	Entpd1(-/-) macrophages exposed to millimolar concentrations of ATP were more susceptible to cell death, released more IL-1beta and IL-18 after TLR2 or TLR4 priming, and incorporated the fluorescent dye Yo-Pro-1 more efficiently (suggestive of increased pore formation) than Entpd1(+/+) cells.	Adenosine Triphosphate	64-67	interleukin 1 beta	Mus musculus	119-127
20067833-7	2010	Glucose-induced attenuation of IRS-2/Akt-mediated signalling was associated with increased IL-1beta expression.	Glucose	0-7	interleukin 1 beta	Mus musculus	91-99
20067833-11	2010	These results indicated that glucose-induced endogenous IL-1beta expression increased betaTC-6 cells apoptosis by inhibiting, at least in part, IRS-2/Akt-mediated signalling through SOCS-1 upregulation.	Glucose	29-36	interleukin 1 beta	Mus musculus	56-64
20132809-8	2010	Three weeks after DSS removal, the polyphenol caused substantial reductions of the rise of pro-inflammatory cytokines, TNF-alpha and IL-1beta and an increase of the anti-inflammatory cytokine IL-10.	Polyphenols	35-45	interleukin 1 beta	Mus musculus	133-141
20067833-0	2010	High glucose induces suppression of insulin signalling and apoptosis via upregulation of endogenous IL-1beta and suppressor of cytokine signalling-1 in mouse pancreatic beta cells.	Glucose	5-12	interleukin 1 beta	Mus musculus	100-108
20067833-4	2010	The aim of this study was to investigate whether high glucose can influence endogenous interleukin-1beta (IL-1beta) and SOCS expression thus affecting insulin signalling and survival in insulin-producing mouse pancreatic beta cells (betaTC-6).	Glucose	54-61	interleukin 1 beta	Mus musculus	87-104
20067833-4	2010	The aim of this study was to investigate whether high glucose can influence endogenous interleukin-1beta (IL-1beta) and SOCS expression thus affecting insulin signalling and survival in insulin-producing mouse pancreatic beta cells (betaTC-6).	Glucose	54-61	interleukin 1 beta	Mus musculus	106-114
19882302-5	2010	Oral administration of HY8004 inhibited TNBS-induced colon shortening and myeloperoxidase activity in the colon of C3H/HeN and C3H/HeJ mice as well as IL-1 beta and TNF-alpha expression.	hy8004	23-29	interleukin 1 beta	Mus musculus	151-160
20188213-8	2010	The results showed that compared with untreated CIA mice, curcumin-treated mice downregulated clinical arthritis score, the proliferation of splenic T cells, expression levels of TNF-alpha and IL-1beta in the ankle joint, and expression levels of IgG2a in serum.	Curcumin	58-66	interleukin 1 beta	Mus musculus	193-201
20159052-0	2010	Fluorofenidone protects mice from lethal endotoxemia through the inhibition of TNF-alpha and IL-1beta release.	5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone	0-14	interleukin 1 beta	Mus musculus	93-101
19956958-5	2010	RESULT: Intrarectal treatment of TNBS in mice caused colon shortening and also increased colonic expression of IL-1beta, IL-6, and TNF-alpha expression.	Trinitrobenzenesulfonic Acid	33-37	interleukin 1 beta	Mus musculus	111-119
20159052-7	2010	In conclusion, these results indicate that AKF-PD inhibits the release of the proinflammatory cytokines (TNF-a and IL-1beta) and improves survival during lethal endotoxemia, which suggest this new pyridone agent can be a novel candidate for therapy of septic shock.	Pyridones	197-205	interleukin 1 beta	Mus musculus	115-123
19956958-6	2010	Oral administration of lancemaside A (10 and 20 mg/kg), inhibited colon shortening and myeloperoxidase activity in TNBS-induced colitic mice and also decreased colonic expression of IL-1beta, IL-6, and TNF-alpha.	lancemaside A	23-36	interleukin 1 beta	Mus musculus	182-190
20132469-4	2010	The protective effect of curcumin was associated with a significant attenuation in the acute pericontusional expression of interleukin-1beta, a pro-inflammatory cytokine, after injury.	Curcumin	25-33	interleukin 1 beta	Mus musculus	123-140
20132469-6	2010	Notably, curcumin blocked IL-1beta-induced aquaporin-4 expression in cultured astrocytes, an effect mediated, at least in part, by reduced activation of the p50 and p65 subunits of nuclear factor kappaB.	Curcumin	9-17	interleukin 1 beta	Mus musculus	26-34
20074668-7	2010	Cytokine analysis of bronchoalveolar lavage fluid (BALF) from RSV-infected mice treated with or without TBBPA revealed that TBBPA significantly increased the levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and interferon (IFN)-gamma at each time point after virus infection, but no change was observed for IL-1beta and IL-12.	tetrabromobisphenol A	124-129	interleukin 1 beta	Mus musculus	322-330
20223588-10	2010	Perineural injection of nicotine (20nmol), a macrophage suppressor, prevented PSL-induced neuropathic pain and suppressed MIP-1alpha and IL-1beta expressions.	Nicotine	24-32	interleukin 1 beta	Mus musculus	137-145
20218969-3	2010	Results showed that exogenously added apoE suppressed the LPS and poly(I-C) induction of IL (interleukin)-6, IL-1beta and TNF-alpha (tumour necrosis factor-alpha) secretion by RAW 264.7 cells.	Poly I-C	66-75	interleukin 1 beta	Mus musculus	109-117
20128771-8	2010	Based on these findings, we suggest that Z-FA.FMK might act as a proliferative mediator which is controlled by IL-1beta through NF-kappaB and oxidative stress in duodenal epithelial cells of D-GalN/TNF-alpha-administered mice.	z-fa	41-45	interleukin 1 beta	Mus musculus	111-119
20128771-8	2010	Based on these findings, we suggest that Z-FA.FMK might act as a proliferative mediator which is controlled by IL-1beta through NF-kappaB and oxidative stress in duodenal epithelial cells of D-GalN/TNF-alpha-administered mice.	FMK	46-49	interleukin 1 beta	Mus musculus	111-119
20707078-1	2010	OBJECTIVE: To investigate the effects of total alkaloid of Sophora alopecuroides (TASA) on expression of serum IL-1beta and IL-4 in mice with DSS-induced acute ulcerative colitis.	tasa	82-86	interleukin 1 beta	Mus musculus	111-119
20707078-1	2010	OBJECTIVE: To investigate the effects of total alkaloid of Sophora alopecuroides (TASA) on expression of serum IL-1beta and IL-4 in mice with DSS-induced acute ulcerative colitis.	Dextran Sulfate	142-145	interleukin 1 beta	Mus musculus	111-119
20074673-5	2010	ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).	1-(3,4-dimethoxy-2--chlorobenzylideneamino)guanidine	0-7	interleukin 1 beta	Mus musculus	142-159
20074673-5	2010	ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).	1-(3,4-dimethoxy-2--chlorobenzylideneamino)guanidine	0-7	interleukin 1 beta	Mus musculus	161-169
20177800-3	2010	Harpagoside, a major iridoid glycoside present in devil"s claw, was found to be one of the active agents in HP-ext and inhibited the production of IL-1beta, IL-6, and TNF-alpha by RAW 264.7.	harpagoside	0-11	interleukin 1 beta	Mus musculus	147-155
20025958-5	2010	Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected.	5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione	62-70	interleukin 1 beta	Mus musculus	221-238
20006963-8	2010	Moreover, 1% aloperine treatment significantly decreased the up-regulated mRNA and protein levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) induced by DNFB in ear biopsy homogenates.	aloperine	13-22	interleukin 1 beta	Mus musculus	142-159
20006963-8	2010	Moreover, 1% aloperine treatment significantly decreased the up-regulated mRNA and protein levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) induced by DNFB in ear biopsy homogenates.	aloperine	13-22	interleukin 1 beta	Mus musculus	161-169
20006963-8	2010	Moreover, 1% aloperine treatment significantly decreased the up-regulated mRNA and protein levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) induced by DNFB in ear biopsy homogenates.	Dinitrofluorobenzene	207-211	interleukin 1 beta	Mus musculus	142-159
20006963-10	2010	The therapeutic mechanism might be related to the reduction of TNF-alpha, IL-1beta and IL-6 production induced by DNFB.	Dinitrofluorobenzene	114-118	interleukin 1 beta	Mus musculus	74-82
20086156-3	2010	Stimulation of PMBC by SEB was effectively blocked by rapamycin as evidenced by the inhibition of tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), IL-6, IL-2, gamma interferon (IFN-gamma), monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, and T-cell proliferation.	pmbc	15-19	interleukin 1 beta	Mus musculus	139-156
20086156-3	2010	Stimulation of PMBC by SEB was effectively blocked by rapamycin as evidenced by the inhibition of tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), IL-6, IL-2, gamma interferon (IFN-gamma), monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, and T-cell proliferation.	pmbc	15-19	interleukin 1 beta	Mus musculus	158-166
20086156-3	2010	Stimulation of PMBC by SEB was effectively blocked by rapamycin as evidenced by the inhibition of tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), IL-6, IL-2, gamma interferon (IFN-gamma), monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, and T-cell proliferation.	Sirolimus	54-63	interleukin 1 beta	Mus musculus	139-156
20086156-3	2010	Stimulation of PMBC by SEB was effectively blocked by rapamycin as evidenced by the inhibition of tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), IL-6, IL-2, gamma interferon (IFN-gamma), monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, and T-cell proliferation.	Sirolimus	54-63	interleukin 1 beta	Mus musculus	158-166
20407409-3	2010	Injection of CAR into the pleural cavity of mice elicited an acute inflammatory response characterized by accumulation of fluid containing a large number of neutrophils (polymorphonuclear leukocytes) in the pleural cavity, infiltration of polymorphonuclear leukocytes in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate, TNF-alpha, and IL-1beta.	Carrageenan	13-16	interleukin 1 beta	Mus musculus	379-387
20302656-11	2010	Butyrate also repressed the production of TNF-alpha, IL-1beta and NO.	Butyrates	0-8	interleukin 1 beta	Mus musculus	53-61
20036321-5	2010	Suppression of SphK1 by its inhibitor, N, N Dimethylsphingosine (DMS), or siRNA resulted in decreased mRNA expression of TNF-alpha, IL-1beta, and iNOS and release of TNF-alpha and nitric oxide (NO) in LPS-activated microglia.	N,N-dimethylsphingosine	39-63	interleukin 1 beta	Mus musculus	132-140
20036321-5	2010	Suppression of SphK1 by its inhibitor, N, N Dimethylsphingosine (DMS), or siRNA resulted in decreased mRNA expression of TNF-alpha, IL-1beta, and iNOS and release of TNF-alpha and nitric oxide (NO) in LPS-activated microglia.	dms	65-68	interleukin 1 beta	Mus musculus	132-140
20036321-6	2010	Moreover, addition of sphingosine 1 phosphate (S1P), a breakdown product of sphingolipid metabolism, increased the expression levels of TNF-alpha, IL-1beta and iNOS and production of TNF-alpha and NO in activated microglia.	sphingosine 1-phosphate	22-45	interleukin 1 beta	Mus musculus	147-155
20159741-9	2010	All doses of tylosin reduced the elevated TNFalpha and IL1beta in LPS-treated mice but increased their IL10 levels.	Tylosin	13-20	interleukin 1 beta	Mus musculus	55-62
19913495-2	2010	In cells from WT mice, 1 mM ATP increased the intracellular concentration of calcium ([Ca(2+)](i)), the uptake of ethidium bromide, the production of reactive oxygen species (ROS), the secretion of IL-1beta, the release of oleic acid and of lactate dehydrogenase; it decreased the intracellular concentration of potassium ([K(+)](i)).	Adenosine Triphosphate	28-31	interleukin 1 beta	Mus musculus	198-206
20025958-5	2010	Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected.	5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione	62-70	interleukin 1 beta	Mus musculus	240-248
20025958-5	2010	Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected.	5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione	103-111	interleukin 1 beta	Mus musculus	221-238
20025958-5	2010	Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected.	5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione	103-111	interleukin 1 beta	Mus musculus	240-248
20127036-7	2010	Furthermore, GOS inhibited the production of inflammatory cytokines such as IL-1beta, IL-6, IL-17, and tumor necrosis factor-alpha but enhanced production of immunomodulatory IL-10.	D-Glucitol-1,6-bisphosphate	13-16	interleukin 1 beta	Mus musculus	76-84
20064106-9	2010	Analysis of cell-free BAL fluids showed significantly increased levels of total proteins, lactate dehydrogenase, tumor necrosis factor-alpha, interleukin-1beta, mucin, and surfactant protein-D (SP-D) in MWCNT-treated mice at day 1 post treatment.	mwcnt	203-208	interleukin 1 beta	Mus musculus	142-159
20020468-7	2010	HO-1 can be induced by H(2)O(2), lipopolysaccharide and inflammatory cytokines such as TNF-alpha and IL-1beta in osteoblasts and also in STZ-induced diabetic mice.	Streptozocin	137-140	interleukin 1 beta	Mus musculus	101-109
20038579-0	2010	Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.	Lysine	0-6	interleukin 1 beta	Mus musculus	107-124
20036165-11	2010	Cardiac allografts treated with tacrolimus showed decreased expression of both ASC and IL-1 beta similar to that seen in isografts.	Tacrolimus	32-42	interleukin 1 beta	Mus musculus	87-96
20216942-11	2010	Mucosal mRNA expression for IL-1beta, TNF-alpha, IL-17 and IP-10 were markedly reduced in the 9.0% cellobiose-fed DSS mice.	Dextran Sulfate	114-117	interleukin 1 beta	Mus musculus	28-36
19940103-4	2010	Resveratrol reversed the colitis-associated decrease in body weight and increased levels of serum amyloid A, tumor necrosis factor-alpha, interleukin (IL-6), and IL-1beta.	Resveratrol	0-11	interleukin 1 beta	Mus musculus	162-170
20596246-0	2010	Ac-YVAD-CMK Decreases Blood-Brain Barrier Degradation by Inhibiting Caspase-1 Activation of Interleukin-1beta in Intracerebral Hemorrhage Mouse Model.	ac-yvad	0-7	interleukin 1 beta	Mus musculus	92-109
20175894-4	2010	METHODS: Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by: accumulation of fluid containing a large number of neutrophils (PMNs) in the pleural cavity, infiltration of PMNs in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate (NOx), tumor necrosis factor-alpha, (TNF-alpha) and interleukin-1beta (IL-1beta).	Carrageenan	22-33	interleukin 1 beta	Mus musculus	385-402
20175894-4	2010	METHODS: Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by: accumulation of fluid containing a large number of neutrophils (PMNs) in the pleural cavity, infiltration of PMNs in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate (NOx), tumor necrosis factor-alpha, (TNF-alpha) and interleukin-1beta (IL-1beta).	Carrageenan	22-33	interleukin 1 beta	Mus musculus	404-412
20038579-0	2010	Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.	Lysine	47-53	interleukin 1 beta	Mus musculus	107-124
20038579-2	2010	Here we report that TNFalpha and IL-1beta induce Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue within the kinase domain.	Lysine	49-52	interleukin 1 beta	Mus musculus	33-41
20038579-2	2010	Here we report that TNFalpha and IL-1beta induce Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue within the kinase domain.	Lysine	95-98	interleukin 1 beta	Mus musculus	33-41
20038579-6	2010	Our findings demonstrate that Lys(63)-linked polyubiquitination of TAK1 at Lys(158) is essential for its own kinase activation and its ability to mediate its downstream signal transduction pathways in response to TNFalpha and IL-1beta stimulation.	Lysine	30-33	interleukin 1 beta	Mus musculus	226-234
20038579-6	2010	Our findings demonstrate that Lys(63)-linked polyubiquitination of TAK1 at Lys(158) is essential for its own kinase activation and its ability to mediate its downstream signal transduction pathways in response to TNFalpha and IL-1beta stimulation.	Lysine	75-78	interleukin 1 beta	Mus musculus	226-234
19961903-6	2010	In addition, RU38486 (glucocorticoid receptor antagonist) decreased the hippocampal IL-1beta mRNA level and abolished the aggravating effect of LPS on KA-induced neuronal death at LPS 90 min and 24 h. In the immunohistochemical study, we found activated and ramified microglia (OX-42) and astrocyte (GFAP) at 24 h after LPS treatment (LPS 24 h) in the hippocampus.	Mifepristone	13-20	interleukin 1 beta	Mus musculus	84-92
20133696-2	2010	The role of ROS in inflammation is controversial; some in vitro studies suggest that ROS are crucial for secretion of IL-1beta via inflammasome activation, whereas mice defective for ROS and patients with CGD have a proinflammatory phenotype.	Reactive Oxygen Species	12-15	interleukin 1 beta	Mus musculus	118-126
19800321-5	2010	KR-31360 also inhibited lipopolysaccharide (LPS)-induced secretion of tumor necrosis factor alpha (TNF-alpha) and transcription of TNF-alpha, interleukin-1 beta, and inducible nitric oxide synthase as well as activation of nuclear factor kappa B and mitogen-activated protein kinases.	KR 31360	0-8	interleukin 1 beta	Mus musculus	142-160
20133696-2	2010	The role of ROS in inflammation is controversial; some in vitro studies suggest that ROS are crucial for secretion of IL-1beta via inflammasome activation, whereas mice defective for ROS and patients with CGD have a proinflammatory phenotype.	Reactive Oxygen Species	85-88	interleukin 1 beta	Mus musculus	118-126
20133696-2	2010	The role of ROS in inflammation is controversial; some in vitro studies suggest that ROS are crucial for secretion of IL-1beta via inflammasome activation, whereas mice defective for ROS and patients with CGD have a proinflammatory phenotype.	Reactive Oxygen Species	85-88	interleukin 1 beta	Mus musculus	118-126
19878665-11	2010	SA13353 attenuated cytokine levels, including TNF-alpha, IL-1beta, IL-12p40, IL-17, and interferon (IFN)-gamma, after proteolipid protein (PLP) immunization.	1-(2-(1-adamantyl)ethyl)-1-pentyl-3-(3-(4-pyridyl)propyl)urea	0-7	interleukin 1 beta	Mus musculus	57-65
19688830-6	2010	The dietary administration with GOFA/beta-CD and AUR/beta-CD inhibited colonic inflammation and also modulated proliferation, apoptosis and the expression of several proinflammatory cytokines, such as nuclear factor-kappaB, tumor necrosis factor-alpha, Stat3, NF-E2-related factor 2, interleukin (IL)-6 and IL-1beta, which were induced in the adenocarcinomas.	gofa	32-36	interleukin 1 beta	Mus musculus	307-315
19857488-4	2010	In addition, hispidol A 25-Me ether inhibits mRNA expressions of major pro-inflammatory cytokines including the tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	hispidol a 25-me	13-29	interleukin 1 beta	Mus musculus	153-170
19857488-4	2010	In addition, hispidol A 25-Me ether inhibits mRNA expressions of major pro-inflammatory cytokines including the tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6).	hispidol a 25-me	13-29	interleukin 1 beta	Mus musculus	172-180
19892861-11	2010	Treatment with rmMFG-E8 significantly suppressed inflammation (TNF-alpha, IL-6, IL-1beta, and myeloperoxidase) and injury of the lungs, liver, and kidneys.	rmmfg-e8	15-23	interleukin 1 beta	Mus musculus	80-88
19878665-3	2010	SA13353 inhibited LPS-induced TNF-alpha and interleukin (IL)-1beta production while augmenting IL-10 production in mice.	1-(2-(1-adamantyl)ethyl)-1-pentyl-3-(3-(4-pyridyl)propyl)urea	0-7	interleukin 1 beta	Mus musculus	44-66
19772681-11	2010	All treatments significantly attenuated the increased DSS-mediated expression levels of IL-1beta.	Dextran Sulfate	54-57	interleukin 1 beta	Mus musculus	88-96
19819333-8	2010	PD98059 also attenuated the lung, liver and pancreatic injury and renal dysfunction caused by zymosan as well as the increase of TNF-alpha and IL-1beta plasma levels caused by zymosan.	Zymosan	176-183	interleukin 1 beta	Mus musculus	143-151
20054868-13	2010	The effect of Kupffer cells on liver triglycerides are at least partially mediated by IL-1beta, which suppresses PPARalpha expression and activity.	Triglycerides	37-50	interleukin 1 beta	Mus musculus	86-94
19819333-8	2010	PD98059 also attenuated the lung, liver and pancreatic injury and renal dysfunction caused by zymosan as well as the increase of TNF-alpha and IL-1beta plasma levels caused by zymosan.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	interleukin 1 beta	Mus musculus	143-151
20112357-11	2010	Bim(-/-) macrophages displayed elevated expression of markers of inflammation and secreted more interleukin-1beta following stimulation with LPS or thioglycollate.	Thioglycolates	148-162	interleukin 1 beta	Mus musculus	96-113
19879381-4	2010	Bisabolangelone also inhibited the productions of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) by suppressing the cytokine mRNA and protein expressions.	bisabolangelone	0-15	interleukin 1 beta	Mus musculus	89-97
19821070-7	2010	The cellular inflammatory response was suppressed on sulfobetaine modified substrates as expression levels of pro-inflammatory cytokines (TNFalpha and IL1beta) was found to be up regulated on bare PMMA, while it was significantly lower on sulfobetaine modified PMMA (**P &lt; 0.001).	sulfobetaine	53-65	interleukin 1 beta	Mus musculus	151-158
19821070-7	2010	The cellular inflammatory response was suppressed on sulfobetaine modified substrates as expression levels of pro-inflammatory cytokines (TNFalpha and IL1beta) was found to be up regulated on bare PMMA, while it was significantly lower on sulfobetaine modified PMMA (**P &lt; 0.001).	Polymethyl Methacrylate	197-201	interleukin 1 beta	Mus musculus	151-158
19821070-7	2010	The cellular inflammatory response was suppressed on sulfobetaine modified substrates as expression levels of pro-inflammatory cytokines (TNFalpha and IL1beta) was found to be up regulated on bare PMMA, while it was significantly lower on sulfobetaine modified PMMA (**P &lt; 0.001).	Polymethyl Methacrylate	261-265	interleukin 1 beta	Mus musculus	151-158
19846588-6	2010	Although cucurbitacin R was found to reduce the inflammatory response brought on by both oxazolone and dinitrofluorobenzene, its activity was even more pronounced against sheep red blood cell-induced edema in mouse paws, with a clear reduction in the production of IL-1beta, IL-4, and tumor necrosis factor alpha in the inflamed paw.	cucurbitacin R	9-23	interleukin 1 beta	Mus musculus	265-273
19874834-8	2010	The serum levels of interleukin-1beta, interleukin-6 and TNF-alpha were significantly increased in arsenic-exposed groups, while in the arsenic-exposed and jaggery supplemented groups their levels were normal.	Arsenic	99-106	interleukin 1 beta	Mus musculus	20-37
19774506-2	2010	Both madecassic acid and madecassoside inhibited the production of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and IL-6.	madecassic acid	5-20	interleukin 1 beta	Mus musculus	156-174
19774506-2	2010	Both madecassic acid and madecassoside inhibited the production of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and IL-6.	madecassic acid	5-20	interleukin 1 beta	Mus musculus	176-184
19774506-2	2010	Both madecassic acid and madecassoside inhibited the production of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and IL-6.	madecassoside	25-38	interleukin 1 beta	Mus musculus	156-174
19774506-2	2010	Both madecassic acid and madecassoside inhibited the production of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), and IL-6.	madecassoside	25-38	interleukin 1 beta	Mus musculus	176-184
19913046-8	2010	The marked increase of proinflammatory cytokines (IL-1beta, IFN-gamma) and chemokines (MCP-1, MIP-2beta, KC) in CCl(4) treated mice was additionally attenuated by ginsan, thereby preventing leukocyte infiltration and local inflammation.	Cefaclor	112-115	interleukin 1 beta	Mus musculus	50-58
19913046-8	2010	The marked increase of proinflammatory cytokines (IL-1beta, IFN-gamma) and chemokines (MCP-1, MIP-2beta, KC) in CCl(4) treated mice was additionally attenuated by ginsan, thereby preventing leukocyte infiltration and local inflammation.	ginsan	163-169	interleukin 1 beta	Mus musculus	50-58
19774506-4	2010	Consistent with these observations, madecassic acid inhibited the LPS-induced expression of iNOS and COX-2 at the protein level and of iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 at the mRNA level in RAW 264.7 macrophage cells, as determined by Western blotting and RT-PCR, respectively.	madecassic acid	36-51	interleukin 1 beta	Mus musculus	159-167
19774506-6	2010	These results suggest that the anti-inflammatory properties of madecassic acid are caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells.	madecassic acid	63-78	interleukin 1 beta	Mus musculus	117-125
20026303-2	2010	In present study, carabrol demonstrated the inhibitory activity on pro-inflammatory cytokines such as IL-1beta, IL-6 and TNF-alpha.	carabrol	18-26	interleukin 1 beta	Mus musculus	102-110
19892005-5	2010	However, in the brains of LPS-exposed mice, ultrafine TiO(2) significantly elevated proinflammatory cytokine interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) mRNAs, and IL-1beta protein levels.	lps	26-29	interleukin 1 beta	Mus musculus	109-126
19892005-5	2010	However, in the brains of LPS-exposed mice, ultrafine TiO(2) significantly elevated proinflammatory cytokine interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) mRNAs, and IL-1beta protein levels.	lps	26-29	interleukin 1 beta	Mus musculus	128-136
19892005-5	2010	However, in the brains of LPS-exposed mice, ultrafine TiO(2) significantly elevated proinflammatory cytokine interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) mRNAs, and IL-1beta protein levels.	lps	26-29	interleukin 1 beta	Mus musculus	193-201
20071520-5	2010	Extensive phosphorylation of p38 MAPK in microglial cells in the dorsal horn was found to correlate with IL-1beta secretion following both LPS and ATP.	Adenosine Triphosphate	147-150	interleukin 1 beta	Mus musculus	105-113
19897006-6	2010	ZnO had the most drastic immunological effects leading to high expression of proinflammatory cytokine, IL-1beta, and enhanced production of neutrophil chemoattractant CXCL-9 on both cell types.	Zinc Oxide	0-3	interleukin 1 beta	Mus musculus	103-111
20108331-5	2010	The expression of interleukin-1beta and macrophage-migration inhibitory factor in the DSS + 0.1% GTP group were lower than the DSS alone group, whereas the expression levels were increased in the DSS + 0.5% GTP and DSS + 1% GTP groups when compared with the DSS alone group.	Dextran Sulfate	127-130	interleukin 1 beta	Mus musculus	18-35
20821823-10	2010	Similarly, ETH exhibited significant suppression of IL-1beta, TNF-alpha, TGF-beta1 and fibronectin when cultured with BV.	eth	11-14	interleukin 1 beta	Mus musculus	52-60
20108331-5	2010	The expression of interleukin-1beta and macrophage-migration inhibitory factor in the DSS + 0.1% GTP group were lower than the DSS alone group, whereas the expression levels were increased in the DSS + 0.5% GTP and DSS + 1% GTP groups when compared with the DSS alone group.	Dextran Sulfate	86-89	interleukin 1 beta	Mus musculus	18-35
20108331-5	2010	The expression of interleukin-1beta and macrophage-migration inhibitory factor in the DSS + 0.1% GTP group were lower than the DSS alone group, whereas the expression levels were increased in the DSS + 0.5% GTP and DSS + 1% GTP groups when compared with the DSS alone group.	Dextran Sulfate	127-130	interleukin 1 beta	Mus musculus	18-35
20108331-5	2010	The expression of interleukin-1beta and macrophage-migration inhibitory factor in the DSS + 0.1% GTP group were lower than the DSS alone group, whereas the expression levels were increased in the DSS + 0.5% GTP and DSS + 1% GTP groups when compared with the DSS alone group.	Guanosine Triphosphate	97-100	interleukin 1 beta	Mus musculus	18-35
20034026-8	2010	Furthermore, the results obtained in mice treated with DEN to induce hepatocarcinogenesis showed, after treatment with a PARP inhibitor (DPQ), a significant reduction both in preneoplastic foci and in the expression of preneoplastic markers and proinflammatory genes (Gstm3, Vegf, Spp1 [Opn], IL6, IL1b, and Tnf), bromodeoxyuridine incorporation, and NF-kappaB activation in the initial steps of carcinogenesis (P &lt; 0.05).	3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone	137-140	interleukin 1 beta	Mus musculus	298-302
20108331-5	2010	The expression of interleukin-1beta and macrophage-migration inhibitory factor in the DSS + 0.1% GTP group were lower than the DSS alone group, whereas the expression levels were increased in the DSS + 0.5% GTP and DSS + 1% GTP groups when compared with the DSS alone group.	Dextran Sulfate	127-130	interleukin 1 beta	Mus musculus	18-35
20108331-5	2010	The expression of interleukin-1beta and macrophage-migration inhibitory factor in the DSS + 0.1% GTP group were lower than the DSS alone group, whereas the expression levels were increased in the DSS + 0.5% GTP and DSS + 1% GTP groups when compared with the DSS alone group.	Dextran Sulfate	127-130	interleukin 1 beta	Mus musculus	18-35
19822999-12	2010	Further, the serum levels of the TNF-alpha and supernatant IL-1 beta concentrations in mice fed a high-carbohydrate diet were significantly increased after the mice were shifted to a high-fat diet.	Carbohydrates	103-115	interleukin 1 beta	Mus musculus	59-68
19264522-9	2010	treatment with SB225002 significantly attenuated the increase in MPO activity or the elevation of IL-1beta, TNFalpha or KC levels following carrageenan injection.	SB 225002	15-23	interleukin 1 beta	Mus musculus	98-106
20034026-8	2010	Furthermore, the results obtained in mice treated with DEN to induce hepatocarcinogenesis showed, after treatment with a PARP inhibitor (DPQ), a significant reduction both in preneoplastic foci and in the expression of preneoplastic markers and proinflammatory genes (Gstm3, Vegf, Spp1 [Opn], IL6, IL1b, and Tnf), bromodeoxyuridine incorporation, and NF-kappaB activation in the initial steps of carcinogenesis (P &lt; 0.05).	Diethylnitrosamine	55-58	interleukin 1 beta	Mus musculus	298-302
19923575-2	2010	Autologous cytokines, such as interleukin-1beta (IL-1beta), are potential adjuvants for mucosal vaccines and can be provided by recombinant lactic acid bacteria.	Lactic Acid	140-151	interleukin 1 beta	Mus musculus	49-57
19544382-5	2010	CA-074Me, a specific inhibitor for CB, inhibited the pro-IL-1beta maturation and its release from microglia.	CA 074 methyl ester	0-8	interleukin 1 beta	Mus musculus	57-65
19932008-11	2010	Furthermore, topical application of triolein (10%) significantly prevented UV-induced MMP-13, COX-2, and IL-1beta expression in hairless mice.	Triolein	36-44	interleukin 1 beta	Mus musculus	105-113
20703013-5	2010	The elevated serum levels of tumor necrosis factor-alpha and IL-1beta in the CIA mice were also restored to control levels via honokiol treatment.	honokiol	127-135	interleukin 1 beta	Mus musculus	61-69
21303327-8	2010	The level of proinflammatory cytokines such as IL-1beta, TNF-alpha and CRP, which were elevated during irradiation, was significantly reduced by the Perillic acid administration.	perillic acid	149-162	interleukin 1 beta	Mus musculus	47-55
20093788-4	2010	Also, MCF-GLE strongly inhibited the releases of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) and significantly suppressed the mRNA and protein expression of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW 264.7 macrophage cells in a dose-dependent manner.	GLE	10-13	interleukin 1 beta	Mus musculus	142-159
20093788-4	2010	Also, MCF-GLE strongly inhibited the releases of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) and significantly suppressed the mRNA and protein expression of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW 264.7 macrophage cells in a dose-dependent manner.	GLE	10-13	interleukin 1 beta	Mus musculus	161-169
20625233-7	2010	In these assays, D-limonene decreased the expression of TNF-alpha, IL-1beta, and IL-6 in a dose-dependent manner.	Limonene	17-27	interleukin 1 beta	Mus musculus	67-75
19626424-6	2010	Furthermore, we examined the ability of the cells to release cytokine when stimulated with both nicotine and LPS and showed that the stimulation with LPS augmented the secretion of IL-1a, IL-1b, IL-6, and TNF-alpha.	Nicotine	96-104	interleukin 1 beta	Mus musculus	188-193
19931338-5	2010	Significant increases in interleukin-1beta and tumor necrosis factor-alpha mRNA were observed in the frontal cortex of azoxymethane-treated wild-type mice at coma stages of encephalopathy.	Azoxymethane	119-131	interleukin 1 beta	Mus musculus	25-42
19786147-10	2010	Pre-incubation of stigmasterol to IL-1beta-treated cells significantly decreased these effects described above (significant reduction of MMP-3 mRNA in human and mouse, MMP-3 protein in mouse, MMP-13 mRNA in mouse and human, ADAMTS-4 mRNA in human, PGE(2) protein in human and mouse) Finally, stigmasterol was capable of counteracting the IL-1beta-induced NF-kappaB pathway.	Stigmasterol	18-30	interleukin 1 beta	Mus musculus	338-346
19455572-3	2010	Glabridin dose-dependently attenuated lipopolysaccharide (LPS)-induced production of inflammatory mediators, including nitric oxide, tumor necrosis factor-alpha and interleukin-1beta, in BV-2 cells, a murine microglia cell line.	glabridin	0-9	interleukin 1 beta	Mus musculus	165-182
19602992-11	2010	Chlorpromazine-treated hypothermic mice had 2.3-fold and 1.8-fold higher plasma interleukin-6 and interleukin-10 levels at 6 hrs compared with identically treated normothermic mice (p &lt; .05), whereas plasma tumor necrosis factor-alpha and interleukin-1beta were not significantly different at 2 hrs or 6 hrs.	Chlorpromazine	0-14	interleukin 1 beta	Mus musculus	242-259
19761873-7	2009	Conversely, BMDC avoided the expression of IL-1beta at days 30 and 60 and TGF-beta only at day 30.	bmdc	12-16	interleukin 1 beta	Mus musculus	43-51
20007584-6	2009	Finally, IL-1beta production and inflammation are reduced in mice deficient for the NALP3 inflammasome component apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and we identified uric acid, which is produced upon elastase-induced lung injury, as an activator of the NALP3/ASC inflammasome.	Uric Acid	218-227	interleukin 1 beta	Mus musculus	9-17
19712723-6	2009	Interestingly, treatment with EP2 antagonist AH-6809 resulted in suppression of hypoxia induced EP2, IL-1beta and iNOS mRNA and protein expression, TNF-alpha protein expression and intracellular cAMP level in BV-2 cells.	6-isopropoxy-9-oxoxanthene-2-carboxylic acid	45-52	interleukin 1 beta	Mus musculus	101-109
19748795-8	2009	ZD 7155 also reduced the mRNA expression of TNF-alpha and IL-1 beta, inhibited the activation of NF-kappaB and AP-1, and improved lung histopathology.	ZD 7155	0-7	interleukin 1 beta	Mus musculus	58-67
19631617-0	2009	Elevated interleukin-1beta induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine aggravating dopaminergic neurodegeneration in old male mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	38-82	interleukin 1 beta	Mus musculus	9-26
19631617-7	2009	In conclusion, the present study demonstrated that elevated IL-1beta gene expression at early period of time may be in part responsible for the DA neuron susceptibility to MPTP in old male mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	172-176	interleukin 1 beta	Mus musculus	60-68
19265174-3	2009	In the present study, we examined the role of the proinflammatory cytokines IL-18 and IL-1beta in the mechanism of bleomycin-induced lung injury.	Bleomycin	115-124	interleukin 1 beta	Mus musculus	86-94
19265174-7	2009	Intravenous administration of bleomycin induced the expression of IL-1beta and IL-18 in the serum and lungs of wild-type C57BL/6 mice.	Bleomycin	30-39	interleukin 1 beta	Mus musculus	66-74
19954533-0	2009	Pathway focused protein profiling indicates differential function for IL-1B, -18 and VEGF during initiation and resolution of lung inflammation evoked by carbon nanoparticle exposure in mice.	Carbon	154-160	interleukin 1 beta	Mus musculus	70-75
19464323-2	2009	Activation of P2X7 receptors is the mechanism by which ATP stimulates the rapid maturation and release of IL-1beta from macrophages and microglial cells.	Adenosine Triphosphate	55-58	interleukin 1 beta	Mus musculus	106-114
19481752-5	2009	Hypercholesterolemic, atherosclerotic ApoE(-/-) mice on CD exhibited increased macrophages and T-cells in plaques and periadventitial adipose tissue that revealed elevated expression of MIP-1alpha, IL-1beta, IL-1 receptor, and IL-6.	Cadmium	56-58	interleukin 1 beta	Mus musculus	198-206
19051282-9	2009	PFOA elevated the expression of proinflammatory cytokines (tumor necrosis factor alpha, interleukin-1beta, and interleukin-6) in the spleen, and proto-oncogene, c-myc, in the spleen and thymus.	perfluorooctanoic acid	0-4	interleukin 1 beta	Mus musculus	88-105
19875734-5	2009	RESULTS: Ten- but not 6-mg/kg of Ac-YVAD-CMK significantly inhibited a post-SAH increase in the activation of interleukin-1beta and caspase-3 and the number of terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling-positive pulmonary endothelial cells, preventing neurogenic pulmonary edema.	ac-yvad	33-40	interleukin 1 beta	Mus musculus	110-127
19805535-7	2009	By using LPS-primed macrophages as a model system, it was determined that IL-1beta secretion was dependent on caspase-1, potassium efflux, and the activity of serine proteases.	Potassium	121-130	interleukin 1 beta	Mus musculus	74-82
20041738-8	2009	In addition, resveratrol consumption reduced LPS-induced interleukin-1beta (IL-1beta) in plasma and the IL-1beta mRNA in the hippocampus of aged mice.	Resveratrol	13-24	interleukin 1 beta	Mus musculus	57-74
20041738-8	2009	In addition, resveratrol consumption reduced LPS-induced interleukin-1beta (IL-1beta) in plasma and the IL-1beta mRNA in the hippocampus of aged mice.	Resveratrol	13-24	interleukin 1 beta	Mus musculus	76-84
20041738-8	2009	In addition, resveratrol consumption reduced LPS-induced interleukin-1beta (IL-1beta) in plasma and the IL-1beta mRNA in the hippocampus of aged mice.	Resveratrol	13-24	interleukin 1 beta	Mus musculus	104-112
20041738-9	2009	Finally, pretreatment of BV-2 microglial cells with resveratrol potently inhibited LPS-induced IL-1beta production.	Resveratrol	52-63	interleukin 1 beta	Mus musculus	95-103
19819943-8	2009	FFA-induced IL-1beta and KC expression in mouse islets was completely dependent on the IL-1R/Toll-like receptor (TLR) docking protein Myd88 and partly dependent on TLR2 and -4.	Fatty Acids, Nonesterified	0-3	interleukin 1 beta	Mus musculus	12-20
20193280-3	2009	RESULTS: At 24 h post-injection, mice receiving rHDL74 [TNF-alpha: (24 +/- 3) pg/ml; IL-1beta: (45 +/- 5) pg/ml] had a significant decrease of plasma tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta) as compared with control mice receiving either saline or rHDLwt [TNF-alpha: (135 +/- 12) pg/ml; IL-1beta: (82 +/- 8) pg/ml, P &lt; 0.05].	Sodium Chloride	270-276	interleukin 1 beta	Mus musculus	85-93
19864602-5	2009	Exposure of LPS-activated macrophages to 6-ethyl chenodeoxycholic acid (6E-CDCA; INT-747) a synthetic FXR ligand, results in a reciprocal regulation of NF-kappaB dependent-genes (TNF-alpha, IL-1beta, IL-6, COX-1, COX-2, and iNOS) and induction of SHP, a FXR-regulated gene.	obeticholic acid	41-70	interleukin 1 beta	Mus musculus	190-198
19864602-5	2009	Exposure of LPS-activated macrophages to 6-ethyl chenodeoxycholic acid (6E-CDCA; INT-747) a synthetic FXR ligand, results in a reciprocal regulation of NF-kappaB dependent-genes (TNF-alpha, IL-1beta, IL-6, COX-1, COX-2, and iNOS) and induction of SHP, a FXR-regulated gene.	obeticholic acid	72-79	interleukin 1 beta	Mus musculus	190-198
19699788-3	2009	RESULTS: Here, we report that SB displays anti-inflammatory effects in a zymosan-induced mouse air-pouch model by reducing the expression of nitric oxide (NO), inducible NOS (iNOS), Cyclooxygenase2 (COX-2), Prostaglandin E2 (PGE2), Nuclear Factor-kappaB (NF-kappaB) and IkappaBalpha as well as inflammatory cytokines, such as IL-1beta, IL-2, IL-6, IL-12 and TNF-alpha.	Antimony	30-32	interleukin 1 beta	Mus musculus	326-334
19244203-11	2009	Azithromycin, added to cell cultures at 1 mg/liter, significantly reduced proinflammatory cytokine expression (IL-1beta, CCL-2, TNF-alpha) in M1-induced CF and wild-type alveolar macrophages.	Azithromycin	0-12	interleukin 1 beta	Mus musculus	111-119
19765544-4	2009	Minocycline repressed the expression of TNF-alpha, IL-1beta, and iNOS, decreased the apoptotic index, and inhibited poly(ADP-ribose) polymerase-1 (PARP-1) activity in the mouse small intestine.	Minocycline	0-11	interleukin 1 beta	Mus musculus	51-59
19699788-4	2009	In a similar manner, SB also reduced the production of nitric oxide, PGE2, IL-1beta, IL-2, IL-6, IL-12 and TNF-alpha, by decreasing the expression of iNOS, COX-2, IkappaB kinase alphabeta (IKKalphabeta) phosphorylation, IkappaBalpha and IkappaBalpha phosphorylation in LPS-treated Raw 264.7 cells.	Antimony	21-23	interleukin 1 beta	Mus musculus	75-83
19699788-7	2009	CONCLUSIONS: Taken together, these results confirm the strong anti-inflammatory properties of SB by inhibition of iNOS, COX-2, PGE2, IL-1beta, IL-2, IL-6, IL-12 and TNF-alpha expression.	Antimony	94-96	interleukin 1 beta	Mus musculus	133-141
19054826-13	2009	The expression of tumour necrosis factor alpha, IL-1beta, IL-6, matrix metalloproteinase 3, cyclooxygenase 2 and inducible nitric oxide synthase decreased in bortezomib-treated mice compared with untreated mice.	Bortezomib	158-168	interleukin 1 beta	Mus musculus	48-56
19994584-4	2009	NMDA increased the expression of interleukin-1beta and TNF-alpha, and endothelial adhesion molecules, including ICAM-1, and induced leukocyte accumulation in the retinal vessels.	N-Methylaspartate	0-4	interleukin 1 beta	Mus musculus	33-50
20023228-6	2009	Production of interleukin-1beta (IL-1beta) and nitric oxide (NO) in response to lipopolysaccharide (LPS) and/or desferrioxamine (DFX) was examined in vitro.	Deferoxamine	112-127	interleukin 1 beta	Mus musculus	14-31
20023228-6	2009	Production of interleukin-1beta (IL-1beta) and nitric oxide (NO) in response to lipopolysaccharide (LPS) and/or desferrioxamine (DFX) was examined in vitro.	Deferoxamine	112-127	interleukin 1 beta	Mus musculus	33-41
20023228-6	2009	Production of interleukin-1beta (IL-1beta) and nitric oxide (NO) in response to lipopolysaccharide (LPS) and/or desferrioxamine (DFX) was examined in vitro.	Deferoxamine	129-132	interleukin 1 beta	Mus musculus	14-31
20023228-6	2009	Production of interleukin-1beta (IL-1beta) and nitric oxide (NO) in response to lipopolysaccharide (LPS) and/or desferrioxamine (DFX) was examined in vitro.	Deferoxamine	129-132	interleukin 1 beta	Mus musculus	33-41
20023228-9	2009	Interestingly, while LPS and LPS+DFX elicited a similar IL-1beta response in macrophages from the 2 mouse types, NO production was blunted in HIF-1alpha KO macrophages.	Deferoxamine	33-36	interleukin 1 beta	Mus musculus	56-64
19767119-5	2009	IL-1beta treatment for 1h activated JNK and resulted in both post-translational modification and reduction of nuclear RXRalpha.	Hydrogen	23-25	interleukin 1 beta	Mus musculus	0-8
19760679-5	2009	Conversely, accumulation of beta-carotene was negatively correlated with the transcription of immune-active molecules, such as IL-1beta, IL-6, and IL-12 p40, in cells stimulated by LPS and INF-gamma.	beta Carotene	28-41	interleukin 1 beta	Mus musculus	127-135
19760679-6	2009	The transcription of the pro-inflammatory cytokines IL-1beta and IL-6 was more sensitive to the accumulation of beta-carotene than was IL-12 p40.	beta Carotene	112-125	interleukin 1 beta	Mus musculus	52-60
19666099-7	2009	Administration of SB 216763 or LiCl inhibited cochlear destruction and the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 in cisplatin-injected mice.	SB 216763	18-27	interleukin 1 beta	Mus musculus	130-147
19666099-7	2009	Administration of SB 216763 or LiCl inhibited cochlear destruction and the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 in cisplatin-injected mice.	SB 216763	18-27	interleukin 1 beta	Mus musculus	149-157
19666099-7	2009	Administration of SB 216763 or LiCl inhibited cochlear destruction and the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 in cisplatin-injected mice.	Lithium Chloride	31-35	interleukin 1 beta	Mus musculus	130-147
19666099-7	2009	Administration of SB 216763 or LiCl inhibited cochlear destruction and the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 in cisplatin-injected mice.	Lithium Chloride	31-35	interleukin 1 beta	Mus musculus	149-157
19812204-3	2009	NaB, but not sodium formate, was found to inhibit LPS-induced expression of inducible NO synthase (iNOS), proinflammatory cytokines (TNF-alpha and IL-1beta) and surface markers (CD11b, CD11c, and CD68) in mouse microglia.	nab	0-3	interleukin 1 beta	Mus musculus	147-155
19812204-4	2009	Similarly, NaB also inhibited fibrillar amyloid beta (Abeta)-, prion peptide-, double-stranded RNA (polyinosinic-polycytidylic acid)-, HIV-1 Tat-, 1-methyl-4-phenylpyridinium(+)-, IL-1beta-, and IL-12 p40(2)-induced microglial expression of iNOS.	nab	11-14	interleukin 1 beta	Mus musculus	180-188
19675207-0	2009	Cholesterol-dependent cytolysins induce rapid release of mature IL-1beta from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner.	Cholesterol	0-11	interleukin 1 beta	Mus musculus	64-72
19675207-3	2009	IL-1beta secretion depends on functional toxin pore formation, as free cholesterol, which prevents TLO binding to cell membranes, blocks the cytokine release.	Cholesterol	71-82	interleukin 1 beta	Mus musculus	0-8
19675207-5	2009	IL-1beta release at a low TLO dose requires potassium efflux, calcium influx, and the activities of calcium-independent PLA(2), caspase-1, and cathepsin B.	Potassium	44-53	interleukin 1 beta	Mus musculus	0-8
19675207-5	2009	IL-1beta release at a low TLO dose requires potassium efflux, calcium influx, and the activities of calcium-independent PLA(2), caspase-1, and cathepsin B.	Calcium	62-69	interleukin 1 beta	Mus musculus	0-8
19675207-5	2009	IL-1beta release at a low TLO dose requires potassium efflux, calcium influx, and the activities of calcium-independent PLA(2), caspase-1, and cathepsin B.	Calcium	100-107	interleukin 1 beta	Mus musculus	0-8
19690824-8	2009	Cannabidiol reduced colon injury, inducible iNOS (but not cyclooxygenase-2) expression, and interleukin-1beta, interleukin-10, and endocannabinoid changes associated with 2,4,6-dinitrobenzene sulfonic acid administration.	Cannabidiol	0-11	interleukin 1 beta	Mus musculus	92-109
19721414-13	2009	IL-6 was by far the most induced acute-phase-cytokine in GD- and zymosan-treated livers, although IL-1beta and TNF-alpha were also strongly upregulated by zymosan and to a lesser extent by GD.	Zymosan	155-162	interleukin 1 beta	Mus musculus	98-106
19699326-8	2009	The immunosuppressive effects on IL-1beta and IL-6 production and on TLR expression by stressed mice might have occurred due to a higher corticosterone production during stress.	Corticosterone	137-151	interleukin 1 beta	Mus musculus	33-41
19528034-1	2009	BACKGROUND: Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystal-induced interleukin 1 beta (IL1beta) release contributes to inflammation in subcutaneous air pouch and peritoneal models of acute gout and pseudogout.	Uric Acid	12-28	interleukin 1 beta	Mus musculus	94-112
19528034-1	2009	BACKGROUND: Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystal-induced interleukin 1 beta (IL1beta) release contributes to inflammation in subcutaneous air pouch and peritoneal models of acute gout and pseudogout.	Uric Acid	12-28	interleukin 1 beta	Mus musculus	114-121
19528034-1	2009	BACKGROUND: Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystal-induced interleukin 1 beta (IL1beta) release contributes to inflammation in subcutaneous air pouch and peritoneal models of acute gout and pseudogout.	Uric Acid	30-33	interleukin 1 beta	Mus musculus	114-121
19528034-1	2009	BACKGROUND: Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystal-induced interleukin 1 beta (IL1beta) release contributes to inflammation in subcutaneous air pouch and peritoneal models of acute gout and pseudogout.	Calcium Pyrophosphate	39-70	interleukin 1 beta	Mus musculus	94-112
19528034-1	2009	BACKGROUND: Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystal-induced interleukin 1 beta (IL1beta) release contributes to inflammation in subcutaneous air pouch and peritoneal models of acute gout and pseudogout.	Calcium Pyrophosphate	39-70	interleukin 1 beta	Mus musculus	114-121
19528034-1	2009	BACKGROUND: Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystal-induced interleukin 1 beta (IL1beta) release contributes to inflammation in subcutaneous air pouch and peritoneal models of acute gout and pseudogout.	Calcium Pyrophosphate	72-76	interleukin 1 beta	Mus musculus	94-112
19528034-1	2009	BACKGROUND: Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystal-induced interleukin 1 beta (IL1beta) release contributes to inflammation in subcutaneous air pouch and peritoneal models of acute gout and pseudogout.	Calcium Pyrophosphate	72-76	interleukin 1 beta	Mus musculus	114-121
20396756-3	2009	Beta-cyclohexylethyl glycoside of muramyl dipeptide was more potent than muramyl dipeptide and other derivatives in increasing in vivo antibacterial resistance and in vitro production of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, and interferon-gamma;.	beta-cyclohexylethyl glycoside	0-30	interleukin 1 beta	Mus musculus	187-204
20396756-3	2009	Beta-cyclohexylethyl glycoside of muramyl dipeptide was more potent than muramyl dipeptide and other derivatives in increasing in vivo antibacterial resistance and in vitro production of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, and interferon-gamma;.	Acetylmuramyl-Alanyl-Isoglutamine	34-51	interleukin 1 beta	Mus musculus	187-204
20396756-3	2009	Beta-cyclohexylethyl glycoside of muramyl dipeptide was more potent than muramyl dipeptide and other derivatives in increasing in vivo antibacterial resistance and in vitro production of interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, and interferon-gamma;.	Acetylmuramyl-Alanyl-Isoglutamine	73-90	interleukin 1 beta	Mus musculus	187-204
19628574-7	2009	IL-1beta-induced beta-cell apoptosis was also inhibited in the presence of either the delipidated protein or the deproteinated lipid moieties of HDL, apolipoprotein A1 (the main protein component of HDL), or sphingosine-1-phosphate (a bioactive sphingolipid mostly carried by HDL).	sphingosine 1-phosphate	208-231	interleukin 1 beta	Mus musculus	0-8
19628574-7	2009	IL-1beta-induced beta-cell apoptosis was also inhibited in the presence of either the delipidated protein or the deproteinated lipid moieties of HDL, apolipoprotein A1 (the main protein component of HDL), or sphingosine-1-phosphate (a bioactive sphingolipid mostly carried by HDL).	Sphingolipids	245-257	interleukin 1 beta	Mus musculus	0-8
19477911-11	2009	LPMCs from RA-treated mice produced lower levels of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-17) but more regulatory cytokines (IL-10, TGF-beta) compared with that of untreated mice.	lpmcs	0-5	interleukin 1 beta	Mus musculus	90-98
20074457-2	2009	Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by: accumulation of fluid containing a large number of neutrophils (PMNs) in the pleural cavity, infiltration of PMNs in lung tissues and subsequent adhesion molecule expression (I-CAM and P-selectin), lipid peroxidation, and increased production of tumour necrosis factor-alpha, (TNF-alpha) and interleukin-1beta (IL-1beta).	Carrageenan	13-24	interleukin 1 beta	Mus musculus	407-424
20074457-2	2009	Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by: accumulation of fluid containing a large number of neutrophils (PMNs) in the pleural cavity, infiltration of PMNs in lung tissues and subsequent adhesion molecule expression (I-CAM and P-selectin), lipid peroxidation, and increased production of tumour necrosis factor-alpha, (TNF-alpha) and interleukin-1beta (IL-1beta).	Carrageenan	13-24	interleukin 1 beta	Mus musculus	426-434
19477911-11	2009	LPMCs from RA-treated mice produced lower levels of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-17) but more regulatory cytokines (IL-10, TGF-beta) compared with that of untreated mice.	Radium	11-13	interleukin 1 beta	Mus musculus	90-98
19524419-7	2009	When murine J774 macrophages were incubated with the sesquiterpene lactone, LPS-induced IL-1beta, tumor necrosis factor-alpha (TNF-alpha) and keratinocyte-derived chemokine (KC) release were concentration-dependently inhibited.	sesquiterpene lactone	53-74	interleukin 1 beta	Mus musculus	88-96
19633061-0	2009	Azithromycin and clarithromycin inhibit lipopolysaccharide-induced murine pulmonary neutrophilia mainly through effects on macrophage-derived granulocyte-macrophage colony-stimulating factor and interleukin-1beta.	Azithromycin	0-12	interleukin 1 beta	Mus musculus	195-212
19633061-0	2009	Azithromycin and clarithromycin inhibit lipopolysaccharide-induced murine pulmonary neutrophilia mainly through effects on macrophage-derived granulocyte-macrophage colony-stimulating factor and interleukin-1beta.	Clarithromycin	17-31	interleukin 1 beta	Mus musculus	195-212
19633061-8	2009	In summary, results presented in this article confirm that macrolides can suppress neutrophil-dominated pulmonary inflammation and suggest that the effect is mediated through inhibition of GM-CSF and IL-1beta production by alveolar macrophages.	Macrolides	59-69	interleukin 1 beta	Mus musculus	200-208
19767732-2	2009	Here we show that dying tumor cells release ATP, which then acts on P2X(7) purinergic receptors from DCs and triggers the NOD-like receptor family, pyrin domain containing-3 protein (NLRP3)-dependent caspase-1 activation complex ("inflammasome"), allowing for the secretion of interleukin-1beta (IL-1beta).	Adenosine Triphosphate	44-47	interleukin 1 beta	Mus musculus	277-294
19767732-2	2009	Here we show that dying tumor cells release ATP, which then acts on P2X(7) purinergic receptors from DCs and triggers the NOD-like receptor family, pyrin domain containing-3 protein (NLRP3)-dependent caspase-1 activation complex ("inflammasome"), allowing for the secretion of interleukin-1beta (IL-1beta).	Adenosine Triphosphate	44-47	interleukin 1 beta	Mus musculus	296-304
19553566-6	2009	In addition, roscovitine dose dependently inhibited LPS-induced expression of cyclooxygenase-2 (COX)-2, IL-1beta, and IL-6 but not tumor necrosis factor (TNF)-alpha.	Roscovitine	13-24	interleukin 1 beta	Mus musculus	104-112
19787068-14	2009	Induction of MMP-1 by TNF or IL-1beta is completely blocked by inhibition of ASM with imipramine.	Imipramine	86-96	interleukin 1 beta	Mus musculus	29-37
19788858-4	2009	In addition, honokiol appeared to block the production of cytotoxic cytokines such as interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha, nitric oxide (NO), and reactive oxygen species (ROS).	honokiol	13-21	interleukin 1 beta	Mus musculus	86-108
19684087-11	2009	On the other hand, SB290157 suppressed the increased expression of IL-1beta in the lung in this model, and the intratracheal administration of IL-1beta induced airway obstruction, airway hyperresponsiveness, and neutrophil infiltration in normal mice.	SB 290157	19-27	interleukin 1 beta	Mus musculus	67-75
19607899-5	2009	MATERIALS AND METHODS: The effect of AEDF on proinflammatory cytokine (IL-1beta and IL-6) production was analyzed by ELISA and real-time RT-PCR.	aedf	37-41	interleukin 1 beta	Mus musculus	71-79
19607899-8	2009	RESULTS: AEDF inhibited the production of IL-1beta and IL-6, NF-kappaB activation, IkappaB-alpha degradation, and IKK, Akt, ERK1/2 and JNK activities in LPS-stimulated mouse peritoneal macrophages.	aedf	9-13	interleukin 1 beta	Mus musculus	42-50
19607899-9	2009	CONCLUSIONS: These results suggest that AEDF inhibits proinflammatory cytokine (IL-1beta and IL-6) production in LPS-stimulated mouse peritoneal macrophages, and that these effects are mediated by the inhibition of the activity of IKK/IkappaB/NF-kappaB and the phosphorylation of Akt, ERK1/2, and JNK.	aedf	40-44	interleukin 1 beta	Mus musculus	80-88
19540866-0	2009	Signal-transducing mechanisms of ketamine-caused inhibition of interleukin-1 beta gene expression in lipopolysaccharide-stimulated murine macrophage-like Raw 264.7 cells.	Ketamine	33-41	interleukin 1 beta	Mus musculus	63-81
19540866-3	2009	This study aimed to evaluate the effects of ketamine on the regulation of inflammatory cytokine gene expression, especially IL-1 beta, in lipopolysaccharide (LPS)-activated murine macrophage-like Raw 264.7 cells and its possible signal-transducing mechanisms.	Ketamine	44-52	interleukin 1 beta	Mus musculus	124-133
19540866-12	2009	Co-treatment with ketamine and TLR4 siRNA synergistically ameliorated LPS-caused enhancement of IL-1 beta production.	Ketamine	18-26	interleukin 1 beta	Mus musculus	96-105
19540866-13	2009	Results of this study show that a therapeutic concentration of ketamine can inhibit gene expression of IL-1 beta possibly through suppressing TLR4-mediated signal-transducing phosphorylations of Ras, Raf, MEK1/2, ERK1/2, and IKK and subsequent translocation and transactivation of NF kappaB.	Ketamine	63-71	interleukin 1 beta	Mus musculus	103-112
19706756-8	2009	For example, vinblastine, a prototypic drug of this class, induced the production of IL-1beta, IL-6, and IL-12, increased surface expression of CD40, CD80, CD86, and MHC class II, and augmented T cell-stimulatory capacity of DCs.	Vinblastine	13-24	interleukin 1 beta	Mus musculus	85-93
19523744-6	2009	RESULT(S): Compared with the positive controls, 15-R-LXA(4) reduced the weight of the endometriotic lesions, decreased the concentrations of IL-1beta and TNF-alpha, and lowered the mRNA levels of IL-1beta and TNF-alpha in peritoneal fluid cells.	15-r-lxa	48-56	interleukin 1 beta	Mus musculus	141-149
19825525-13	2009	Dexamethasone not only completely abolished the IL-1beta-induced AHR to bradykinin, but also abrogated the increased mRNA expression for inflammatory mediators, IL-6, IFN-gamma and Cox-2.	Dexamethasone	0-13	interleukin 1 beta	Mus musculus	48-56
19666548-7	2009	Islets from mice deficient in IL-1beta or MyD88 challenged with glucose and palmitate in vitro also produced significantly less IL-6 and chemokines.	Glucose	64-71	interleukin 1 beta	Mus musculus	30-38
19666548-7	2009	Islets from mice deficient in IL-1beta or MyD88 challenged with glucose and palmitate in vitro also produced significantly less IL-6 and chemokines.	Palmitates	76-85	interleukin 1 beta	Mus musculus	30-38
19034653-7	2009	ROS in the colon, the level of interleukin 1 beta (IL-1 beta) in colonic mucosa, serum tumor necrosis factor a (TNF-alpha), MPO, and MDA were significantly increased in DSS-treated animals (P &lt; 0.01), with decreased PON1 activity (P &lt; 0.01).	dss	169-172	interleukin 1 beta	Mus musculus	31-49
19034653-7	2009	ROS in the colon, the level of interleukin 1 beta (IL-1 beta) in colonic mucosa, serum tumor necrosis factor a (TNF-alpha), MPO, and MDA were significantly increased in DSS-treated animals (P &lt; 0.01), with decreased PON1 activity (P &lt; 0.01).	dss	169-172	interleukin 1 beta	Mus musculus	51-60
19034653-8	2009	However, NAC significantly decreased colonic MPO activity, ROS, TNF-alpha and IL-1 beta levels and increased PON1 activity and GSH concentration.	Acetylcysteine	9-12	interleukin 1 beta	Mus musculus	78-87
19570816-7	2009	In addition, exendin-4 also suppressed MPTP-induced expression of pro-inflammatory molecules and tumor necrosis factor alpha and interleukin-1 beta.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	39-43	interleukin 1 beta	Mus musculus	129-147
19620300-8	2009	Kidneys from pioglitazone-treated mice showed significant decreases in immune complex deposition, renal inflammation, T cell glomerular infiltration, and intrarenal synthesis of TNF-alpha, IL-1beta, and VCAM-1.	Pioglitazone	13-25	interleukin 1 beta	Mus musculus	189-197
19486890-3	2009	At day-7, DSS-induced pathogenic outcomes including, loss of body weight, increase of colitis score, pathogenic shortening of colon length, elevated level of IL-12, TNF-alpha and IL-1beta in colon lesion, were significantly suppressed by the addition of H2 to DSS solution.	dss	10-13	interleukin 1 beta	Mus musculus	179-187
19505677-7	2009	RESULTS: Treatment with trehalose suppressed LPS-induced IL-1beta and TNF-alpha production and downregulated transcription of these cytokines.	Trehalose	24-33	interleukin 1 beta	Mus musculus	57-65
19505677-10	2009	CONCLUSION: These results may suggest that trehalose inhibits LPS-induced production of IL-1beta and TNF-alpha in mouse peritoneal macrophages by inhibiting degradation of IkappaB-alphavia the trehalose receptor T1R3.	Trehalose	43-52	interleukin 1 beta	Mus musculus	88-96
19346296-8	2009	Indeed, prior injection of RSV virtually completely attenuated the effects of C5a on vascular permeability, neutrophil migration, release of interleukin 1beta, tumor necrosis factor alpha, interleukin 6, and the chemokine MIP-1alpha.	Resveratrol	27-30	interleukin 1 beta	Mus musculus	141-187
19523744-6	2009	RESULT(S): Compared with the positive controls, 15-R-LXA(4) reduced the weight of the endometriotic lesions, decreased the concentrations of IL-1beta and TNF-alpha, and lowered the mRNA levels of IL-1beta and TNF-alpha in peritoneal fluid cells.	15-r-lxa	48-56	interleukin 1 beta	Mus musculus	196-204
19523744-7	2009	CONCLUSION(S): These findings suggest that 15-R-LXA(4) inhibits the progression of endometriosis possibly by suppressing the gene and protein expression of IL-1beta and TNF-alpha.	15-r-lxa	43-51	interleukin 1 beta	Mus musculus	156-164
19614750-8	2009	IL-1beta neutralization attenuated the CCI-induced cortical and hippocampal microglial activation (P &lt; 0.05 at post-injury days 3 and 7), and cortical infiltration of neutrophils (P &lt; 0.05 at post-injury day 7).	CCI	39-42	interleukin 1 beta	Mus musculus	0-8
19426756-7	2009	Scopolamine treatment in mice increased brain levels of TNF-alpha and IL-1beta expression.	Scopolamine	0-11	interleukin 1 beta	Mus musculus	70-78
19398040-3	2009	Zedoarondiol dose-dependently inhibited LPS-stimulated nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) productions in RAW 264.7 macrophage and in mouse peritoneal macrophage cells.	zedoarondiol	0-12	interleukin 1 beta	Mus musculus	170-187
19398040-3	2009	Zedoarondiol dose-dependently inhibited LPS-stimulated nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) productions in RAW 264.7 macrophage and in mouse peritoneal macrophage cells.	zedoarondiol	0-12	interleukin 1 beta	Mus musculus	189-197
19398040-4	2009	Consistent with these findings, in RAW 264.7 cells, zedoarondiol suppressed the LPS-stimulated protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and the mRNA expressions of iNOS, COX-2, TNF-alpha, IL-6, and IL-1beta in a concentration-dependent manner.	zedoarondiol	52-64	interleukin 1 beta	Mus musculus	243-251
20141614-6	2009	We also showed that strontium ranelate prevented cell apoptosis induced by serum deprivation or the pro-inflammatory cytokines IL-1beta and TNF-alpha in [CaSR(-/-)] and [CaSR(+/+)] osteoblasts, indicating that CaSR is not the only receptor involved in the protective effect of strontium ranelate on osteoblast apoptosis.	strontium ranelate	20-38	interleukin 1 beta	Mus musculus	127-135
20628458-4	2009	The real-time quantitative RT-PCR and ELISA analyses showed that nano-anatase TiO2can significantly alter the mRNA and protein expressions of several inflammatory cytokines, including nucleic factor-kappaB, macrophage migration inhibitory factor, tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, cross-reaction protein, interleukin-4, and interleukin-10.	tio2can	78-85	interleukin 1 beta	Mus musculus	291-308
19426756-8	2009	However, treatment with TA3 and scopolamine inhibited the increase of TNF-alpha and IL-1beta expression.	Scopolamine	32-43	interleukin 1 beta	Mus musculus	84-92
19594948-4	2009	The in vitro experiment then showed that ASEA significantly reduced IL-6 and IL-1beta production and the NF-kappaB trans-activation activity of mitogen-stimulated RAW264.7 cells.	asea	41-45	interleukin 1 beta	Mus musculus	77-85
19427844-10	2009	KA-induced gliosis and proinflammatory marker (COX-2, IL-1beta, and TNF-alpha) inductions were also suppressed by fluoxetine administration.	Fluoxetine	114-124	interleukin 1 beta	Mus musculus	54-62
19446544-4	2009	Dexamethasone prevented piroxicam-induced colitis concurrent with the suppression of interleukin (IL)-1beta, IL-17, tumor necrosis factor alpha and interferon gamma.	Dexamethasone	0-13	interleukin 1 beta	Mus musculus	85-107
19474767-4	2009	Furthermore, nargenicin effectively suppressed the upregulation of interleukin-1beta, tumor necrosis factor alpha, and inducible nitric oxide synthase at both mRNA and protein levels in LPS-stimulated BV-2 microglia.	nargenicin	13-23	interleukin 1 beta	Mus musculus	67-113
19388896-0	2009	Isoflurane attenuates pulmonary interleukin-1beta and systemic tumor necrosis factor-alpha following mechanical ventilation in healthy mice.	Isoflurane	0-10	interleukin 1 beta	Mus musculus	32-49
19508397-9	2009	alpha,beta-Amyrin, like dexamethasone, significantly diminished interleukin (IL)-1beta levels and partially restored IL-10 levels in colon tissues 72 h after colitis induction, but only alpha,beta-amyrin reduced vascular endothelial growth factor expression by immunohistochemistry.	beta-amyrin	6-17	interleukin 1 beta	Mus musculus	64-86
19388896-13	2009	CONCLUSIONS: The present study is the first to show that isoflurane attenuates the pulmonary IL-1beta and systemic TNF-alpha response following MV in healthy mice.	Isoflurane	57-67	interleukin 1 beta	Mus musculus	93-101
19461019-2	2009	The aim of this study is to examine the effects of IL-1beta inactivation on EBI after SAH in mice.	1,2-Diisothiocyanatoethane	76-79	interleukin 1 beta	Mus musculus	51-59
19461019-7	2009	Although both dosages of Ac-YVAD-CMK attenuated the mature IL-1beta induction, only high-dose treatment group significantly inhibited the phosphorylation of JNK, MMP-9 induction, and ZO-1 degradation.	ac-yvad	25-32	interleukin 1 beta	Mus musculus	59-67
19118846-8	2009	The BAL fluid concentrations of interleukin-1beta, interleukin-6, RANTES, and high mobility group box 1 were significantly increased by pneumonectomy and enhanced by the additional administration of bleomycin.	Bleomycin	199-208	interleukin 1 beta	Mus musculus	32-49
19547756-2	2009	We have previously shown that IL-1beta synthesis in the hippocampus is dependent on P2X(7) receptor (P2X(7)R), which is an ionotropic receptor of ATP.	Adenosine Triphosphate	146-149	interleukin 1 beta	Mus musculus	30-38
19376150-8	2009	Moderate concentrations of HOCl (0.35 to 1.4 mM) caused maximal activation of the Nrf2 pathway and innate immune response genes, such as IL-1beta, IL-6, IL-10 and chemokines.	Hypochlorous Acid	27-31	interleukin 1 beta	Mus musculus	137-145
19181340-8	2009	The effects of dexmedetomidine on COX-2 expression and the production of PGE2, TNF-alpha, IL-1beta, IL-6, and IL-10 paralleled the effects of dexmedetomidine on iNOS.	Dexmedetomidine	15-30	interleukin 1 beta	Mus musculus	90-98
19115378-5	2009	Using the BV-2 microglia cell line, we showed that roscovitine not only inhibited oxygen-glucose deprivation (OGD) induced cell cycle activation by arresting the cells at G1/S and G2/M in a dose-dependent manner, but it also inhibited interleukin-1 beta (IL-1beta), macrophage inflammatory protein-1alpha (MIP-1alpha), and nitric oxide (NO) production.	Roscovitine	51-62	interleukin 1 beta	Mus musculus	235-253
19356732-7	2009	Atractylenolide I displayed a potent inhibitory effect on angiogenesis by a set of down-regulatory actions of NO, TNF-alpha, IL-1beta, IL-6, VEGF and PlGF in chronic inflammation.	atractylenolide I	0-17	interleukin 1 beta	Mus musculus	125-133
19697699-0	2009	[Effects of (-)-epigallocatechin-3-gallate on interleukin-1beta expression in mouse wound healing].	epigallocatechin gallate	12-42	interleukin 1 beta	Mus musculus	46-63
19697699-2	2009	In this study, effects of EGCG on the expression of IL-1beta gene and the IL-1beta level at wound sites during cutaneous wound healing were investigated with histological stain, ELISA and RT-PCR technique.	epigallocatechin gallate	26-30	interleukin 1 beta	Mus musculus	52-60
19697699-3	2009	The results show that EGCG (50 mg/L) inhibited the expression of IL-1beta gene and reduced the IL-beta level at wound sites at 72 h after cutaneous wound, but not change the expression of IL-1beta gene and the IL-1beta level at early stage (&lt; or =24 h).	epigallocatechin gallate	22-26	interleukin 1 beta	Mus musculus	65-73
19356732-6	2009	Atractylenolide I could dose-dependently inhibit the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF) activity in the flute of mouse air pouch and the peritoneal macrophages stimulated by lipopolysaccharide (LPS).	atractylenolide I	0-17	interleukin 1 beta	Mus musculus	127-144
19356732-6	2009	Atractylenolide I could dose-dependently inhibit the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF) activity in the flute of mouse air pouch and the peritoneal macrophages stimulated by lipopolysaccharide (LPS).	atractylenolide I	0-17	interleukin 1 beta	Mus musculus	146-154
19214388-2	2009	Talosin A (10 and 50 mug/ml) significantly reduced LPS-induced overproduction of tumor necrosis factor-alpha, interleukin IL-1beta, -6 and NO in a dose-dependent manner (P &lt; 0.01).	genistein 7-(6-deoxytalopyranoside)	0-9	interleukin 1 beta	Mus musculus	122-130
19371329-3	2009	KEY RESULTS: DiOHF (1-30 micromol x L(-1)) concentration-dependently reduced MCP-1 expression in both quiescent cells and cells stimulated with platelet-derived growth factor (PDGF) or interleukin 1-beta.	3',4'-dihydroxyflavonol	13-18	interleukin 1 beta	Mus musculus	185-203
19115378-5	2009	Using the BV-2 microglia cell line, we showed that roscovitine not only inhibited oxygen-glucose deprivation (OGD) induced cell cycle activation by arresting the cells at G1/S and G2/M in a dose-dependent manner, but it also inhibited interleukin-1 beta (IL-1beta), macrophage inflammatory protein-1alpha (MIP-1alpha), and nitric oxide (NO) production.	Roscovitine	51-62	interleukin 1 beta	Mus musculus	255-263
19554401-7	2009	All four fluoroquinolones (100 mg/kg) investigated in this study tended to decrease the serum IL-1beta levels (65.5%-65.9% of control), but this was not a significant change.	Fluoroquinolones	9-25	interleukin 1 beta	Mus musculus	94-102
20107539-7	2009	RESULTS: Cordycepin inhibited the production of NO and pro-inflammatory cytokines such as IL-1beta, IL-6, and TNF-alpha in LPS-activated macrophages via suppressing protein expression of pro-inflammatory mediators.	cordycepin	9-19	interleukin 1 beta	Mus musculus	90-98
19286483-6	2009	MPTP caused a common inflammatory reaction characterized by microglial activation, infiltration of T cells into the substantia nigra and striatum and increased expression of mRNA encoding pro-inflammatory cytokines (IL-1 beta, TNFalpha, INF gamma) and trophic factors (TGFbeta, GDNF).	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	0-4	interleukin 1 beta	Mus musculus	216-225
19554401-10	2009	Ciprofloxacin, gatifloxacin, and norfloxacin (100 mug/ml) inhibited both TNF-alpha (12.1%-69.0% of control) and IL-1beta production (22.1%-68.8% of control).	Ciprofloxacin	0-13	interleukin 1 beta	Mus musculus	112-120
19589095-4	2009	When LPS was added to APAP-treated cells, the increase in TNFalpha and IL-1beta production observed was higher than the sum of cytokine amounts produced with each agent alone, suggesting a synergistic mechanism.	Acetaminophen	22-26	interleukin 1 beta	Mus musculus	71-79
19554401-10	2009	Ciprofloxacin, gatifloxacin, and norfloxacin (100 mug/ml) inhibited both TNF-alpha (12.1%-69.0% of control) and IL-1beta production (22.1%-68.8% of control).	Gatifloxacin	15-27	interleukin 1 beta	Mus musculus	112-120
19554401-10	2009	Ciprofloxacin, gatifloxacin, and norfloxacin (100 mug/ml) inhibited both TNF-alpha (12.1%-69.0% of control) and IL-1beta production (22.1%-68.8% of control).	Norfloxacin	33-44	interleukin 1 beta	Mus musculus	112-120
19589095-9	2009	Furafylline, a CYP1A inhibitor, and indomethacin, a PGHS inhibitor, exhibited a significant inhibitory effect on TNFalpha and IL-1beta production induced by the APAP and LPS combination.	furafylline	0-11	interleukin 1 beta	Mus musculus	126-134
19554401-11	2009	Levofloxacin (100 mug/ml) inhibited IL-1beta production (65.0% of control), but not TNF-alpha production.	Levofloxacin	0-12	interleukin 1 beta	Mus musculus	36-44
19589095-9	2009	Furafylline, a CYP1A inhibitor, and indomethacin, a PGHS inhibitor, exhibited a significant inhibitory effect on TNFalpha and IL-1beta production induced by the APAP and LPS combination.	Indomethacin	36-48	interleukin 1 beta	Mus musculus	126-134
19589095-2	2009	We investigated the effect of subtoxic concentrations of acetaminophen in conjunction with bacterial lipopolysaccharide (LPS) on the expression of the pro-inflammatory cytokines TNFalpha and IL-1beta using the mouse macrophage cell line RAW264.7 as a model.	Acetaminophen	57-70	interleukin 1 beta	Mus musculus	191-199
19589095-9	2009	Furafylline, a CYP1A inhibitor, and indomethacin, a PGHS inhibitor, exhibited a significant inhibitory effect on TNFalpha and IL-1beta production induced by the APAP and LPS combination.	pghs	52-56	interleukin 1 beta	Mus musculus	126-134
19589095-9	2009	Furafylline, a CYP1A inhibitor, and indomethacin, a PGHS inhibitor, exhibited a significant inhibitory effect on TNFalpha and IL-1beta production induced by the APAP and LPS combination.	Acetaminophen	161-165	interleukin 1 beta	Mus musculus	126-134
19589095-3	2009	APAP alone induced in a dose-dependent manner the production of TNFalpha and IL-1beta in this cell line.	Acetaminophen	0-4	interleukin 1 beta	Mus musculus	77-85
17950491-6	2009	Significantly, while rosiglitazone attenuated the LPS-induced increase in MHCII and IL-1 beta concentration in glia prepared from wildtype mice, it failed to exert an effect in glia prepared from IL-4(-/-) mice, thereby suggesting that the anti-inflammatory actions of rosiglitazone are mediated by its ability to increase IL-4 expression.	Rosiglitazone	21-34	interleukin 1 beta	Mus musculus	84-93
19258518-10	2009	The PI3K inhibitor LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride] abolished the H(2)S-mediated activation of AKT and increases tumor necrosis factor alpha and interleukin 1beta levels in caerulein-treated acinar cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	interleukin 1 beta	Mus musculus	187-204
19258518-10	2009	The PI3K inhibitor LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride] abolished the H(2)S-mediated activation of AKT and increases tumor necrosis factor alpha and interleukin 1beta levels in caerulein-treated acinar cells.	LY-294,002 hydrochloride	29-92	interleukin 1 beta	Mus musculus	187-204
19258518-10	2009	The PI3K inhibitor LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride] abolished the H(2)S-mediated activation of AKT and increases tumor necrosis factor alpha and interleukin 1beta levels in caerulein-treated acinar cells.	Hydrogen Sulfide	108-113	interleukin 1 beta	Mus musculus	187-204
19375802-9	2009	Hence, concluded that methylglyoxal augmented the IL-6 and IL-1 beta, expression of TLR 4 and TLR 9 and produced MAPKs, important regulators of ROIs and RNIs.	Pyruvaldehyde	22-35	interleukin 1 beta	Mus musculus	59-68
19545728-12	2009	Silica-gel-entrapped AMT protects islet graft from a nonspecific inflammatory destruction, which is partly mediated via interleukin-1beta.	Silica Gel	0-10	interleukin 1 beta	Mus musculus	120-137
19020550-3	2009	GTPs resulted in reduction in the levels of markers of inflammation (cyclooxygenase-2, prostaglandin E(2), proliferating cell nuclear antigen, and cyclin D1) and proinflammatory cytokines (tumor necrosis factor-alpha, IL-6, and IL-1beta) in chronically UVB-exposed skin and skin tumors of wild-type mice but less effective in IL-12p40-KO mice.	gtps	0-4	interleukin 1 beta	Mus musculus	228-236
19777841-0	2009	[Gastrodine represses expression of IL-1 beta, IL-6 induced by hyperglycemia in gitter cells].	gastrodin	1-11	interleukin 1 beta	Mus musculus	36-45
19777841-2	2009	The aim of this study is to evaluate the inhibitory effect of Gastrodine on the expression of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) in culturing for gitter cells (BV-2 cells) induced by high concentration of glucose.	gastrodin	62-72	interleukin 1 beta	Mus musculus	94-112
19777841-2	2009	The aim of this study is to evaluate the inhibitory effect of Gastrodine on the expression of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) in culturing for gitter cells (BV-2 cells) induced by high concentration of glucose.	gastrodin	62-72	interleukin 1 beta	Mus musculus	114-123
19777841-8	2009	The supernatant protein of IL-1 beta is higher in HCG group than control group (119.53 +/- 15.91) ng x L(-1) vs (25.74 +/- 15.72) ng x L(-1) (P &lt; 0.01), but lower in the gastrodine groups than HCG LG (99.32 +/- 19.66) ng x L(-1), MG (76.94 +/- 17.16) ng x L(-1), HG (88.35 +/- 18.72) ng x L(-1) vs (119.53 +/-15.91) ng x L(-1) (P &lt; 0.05).	gastrodin	173-183	interleukin 1 beta	Mus musculus	27-36
19777841-10	2009	The mRNA expression of IL-1 beta was increased significantly higher in HCG than control group (2.77 +/- 0.29) vs (1.13 +/- 0.27) (P &lt; 0.05), but decreased significantly in gastrodine groups than HCG LGA (2.66 +/- 0.31), MGA (2.1 +/- 0.41), HGA (2.4 +/- 0.28) vs (2.77 +/- 0.29) (P &lt; 0.05).	gastrodin	175-185	interleukin 1 beta	Mus musculus	23-32
19777841-12	2009	CONCLUSION: Gastrodine can inhibit the expression of IL-1 beta, IL-6 in cultured BV-2 cells induced by high concentration of glucose.	gastrodin	12-22	interleukin 1 beta	Mus musculus	53-62
19777841-12	2009	CONCLUSION: Gastrodine can inhibit the expression of IL-1 beta, IL-6 in cultured BV-2 cells induced by high concentration of glucose.	Glucose	125-132	interleukin 1 beta	Mus musculus	53-62
19218193-7	2009	Reduction of uric acid levels using the inhibitor of uric acid synthesis allopurinol or uricase leads to a decrease in BLM-induced IL-1beta production, lung inflammation, repair, and fibrosis.	Uric Acid	13-22	interleukin 1 beta	Mus musculus	131-139
19218193-7	2009	Reduction of uric acid levels using the inhibitor of uric acid synthesis allopurinol or uricase leads to a decrease in BLM-induced IL-1beta production, lung inflammation, repair, and fibrosis.	Uric Acid	53-62	interleukin 1 beta	Mus musculus	131-139
19218193-9	2009	CONCLUSIONS: Uric acid released from injured cells constitutes a major endogenous danger signal that activates the NALP3 inflammasome, leading to IL-1beta production.	Uric Acid	13-22	interleukin 1 beta	Mus musculus	146-154
19218193-10	2009	Reducing uric acid tissue levels represents a novel therapeutic approach to control IL-1beta production and chronic inflammatory lung pathology.	Uric Acid	9-18	interleukin 1 beta	Mus musculus	84-92
19292976-2	2009	The flavonoid fisetin significantly reduced lung myeloperoxidase-levels and gene-expression of inflammatory mediators such as IL-6, TNF-alpha, IL-1beta, MIP-1alpha and MIP-2.	Flavonoids	4-13	interleukin 1 beta	Mus musculus	143-151
19258328-0	2009	NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury.	Hyaluronic Acid	85-95	interleukin 1 beta	Mus musculus	33-50
19258328-0	2009	NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury.	Hyaluronic Acid	85-95	interleukin 1 beta	Mus musculus	52-60
19258328-9	2009	Therefore, the action of CD44 and subsequent hyaluronan catabolism trigger the intracellular cryopyrin --&gt; IL-1beta pathway.	Hyaluronic Acid	45-55	interleukin 1 beta	Mus musculus	110-118
19258328-10	2009	These findings support the hypothesis that hyaluronan works through IL-1beta and the cryopyrin system to signal sterile inflammation.	Hyaluronic Acid	43-53	interleukin 1 beta	Mus musculus	68-76
19349371-5	2009	Consistent with this behavior, gadolinium chloride pretreatment abolished TNF/IL-1beta up-regulation during ischemia without affecting Mn-SOD levels.	gadolinium chloride	31-50	interleukin 1 beta	Mus musculus	78-86
19349371-6	2009	Interestingly, specific glutathione (GSH) up-regulation in hepatocytes by S-adenosylmethionine increased Mn-SOD expression and protected against I/R-mediated liver injury despite TNF/IL-1beta induction.	Glutathione	24-35	interleukin 1 beta	Mus musculus	183-191
19349371-6	2009	Interestingly, specific glutathione (GSH) up-regulation in hepatocytes by S-adenosylmethionine increased Mn-SOD expression and protected against I/R-mediated liver injury despite TNF/IL-1beta induction.	Glutathione	37-40	interleukin 1 beta	Mus musculus	183-191
19349371-6	2009	Interestingly, specific glutathione (GSH) up-regulation in hepatocytes by S-adenosylmethionine increased Mn-SOD expression and protected against I/R-mediated liver injury despite TNF/IL-1beta induction.	S-Adenosylmethionine	74-94	interleukin 1 beta	Mus musculus	183-191
19349371-8	2009	In contrast, indiscriminate hepatic GSH depletion by buthionine-sulfoximine before I/R potentiated oxidative stress and decreased both nuclear p65 and Mn-SOD expression levels, increasing TNF/IL-1beta up-regulation and I/R-induced liver damage.	Glutathione	36-39	interleukin 1 beta	Mus musculus	192-200
19349371-8	2009	In contrast, indiscriminate hepatic GSH depletion by buthionine-sulfoximine before I/R potentiated oxidative stress and decreased both nuclear p65 and Mn-SOD expression levels, increasing TNF/IL-1beta up-regulation and I/R-induced liver damage.	Buthionine Sulfoximine	53-75	interleukin 1 beta	Mus musculus	192-200
19299019-9	2009	These results highlight the complex role of STAT3 in cytokine production and the key role of STAT3 tyrosine phosphorylation in IL-1beta and IL-6 production in response to inflammation.	Tyrosine	99-107	interleukin 1 beta	Mus musculus	127-135
19252937-5	2009	Furthermore, the phosphorylation of ERK 1/2 and the expression of pro-inflammatory cytokines such as IL-1beta, CCL2 and CCL5 were augmented by 1-linoleoyl (C18:2) lysoPtdCho.	1-linoleoyl	143-154	interleukin 1 beta	Mus musculus	101-109
19261731-0	2009	Biotin status affects nickel allergy via regulation of interleukin-1beta production in mice.	Biotin	0-6	interleukin 1 beta	Mus musculus	55-72
19261731-0	2009	Biotin status affects nickel allergy via regulation of interleukin-1beta production in mice.	Nickel	22-28	interleukin 1 beta	Mus musculus	55-72
19261731-12	2009	Biotin supplementation inhibited the augmentation of IL-1beta production in vitro.	Biotin	0-6	interleukin 1 beta	Mus musculus	53-61
19261731-14	2009	These results indicate that biotin status affects Ni allergy in the elicitation phase via the upregulation of IL-1beta production in mice, suggesting that biotin supplementation may have therapeutic effects on human metal allergy.	Biotin	28-34	interleukin 1 beta	Mus musculus	110-118
19261731-14	2009	These results indicate that biotin status affects Ni allergy in the elicitation phase via the upregulation of IL-1beta production in mice, suggesting that biotin supplementation may have therapeutic effects on human metal allergy.	Biotin	155-161	interleukin 1 beta	Mus musculus	110-118
19148883-2	2009	The oral administration of PE (100 and 200 mg/kg per day) for 21 days after subcutaneous immunization with FCA, significantly reduced hindpaw swelling and the production of inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) compared with the FCA-induced arthritis group.	pe	27-29	interleukin 1 beta	Mus musculus	208-216
19299019-0	2009	STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria.	Tyrosine	6-14	interleukin 1 beta	Mus musculus	47-65
19384567-7	2009	Ghrelin prevents MPTP-induced microglial activation in the SNpc and striatum, the expression of pro-inflammatory molecules tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the activation of inducible nitric oxide synthase.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	17-21	interleukin 1 beta	Mus musculus	186-194
19384567-9	2009	Finally, in vitro administration of ghrelin prevented 1-methyl-4-phenylpyridinium-induced dopaminergic cell loss, MMP-3 expression, microglial activation, and the subsequent release of TNF-alpha, IL-1beta, and nitrite in mesencephalic cultures.	1-Methyl-4-phenylpyridinium	54-81	interleukin 1 beta	Mus musculus	196-204
19148883-8	2009	Moreover, administration of PE (100 mg/kg) for 49 days reduced the serum levels of rheumatoid factor, anti-type II collagen antibody, TNF-alpha, IL-1beta, IL-6, protein carbonyl, advanced glycation endproducts, malondialdehyde and LDL-cholesterol compared with that of CIA mice.	pe	28-30	interleukin 1 beta	Mus musculus	145-153
19281601-9	2009	Furthermore, the hexane fraction (300 mg/kg orally) caused inhibition of the nociceptive response induced by intrathecal injection of N-methyl-d-aspartic acid, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, tumour necrosis factor-alpha and interleukin-1beta.	Hexanes	17-23	interleukin 1 beta	Mus musculus	251-268
19170127-3	2009	METHODS: IL-1 beta was administrated intravenously, alone or with dexamethasone (Dex), to separate groups of C57BL/6J mice.	Dexamethasone	66-79	interleukin 1 beta	Mus musculus	9-18
19170127-9	2009	Concomitant administration of Dex, a known NF-kappaB inhibitor, resulted in significantly down-regulated IL-1 beta-induced NF-kappaB/p65 activity, as well as reduced expression of chemokine receptors and IL-17F in mouse prostate tissue.	Dexamethasone	30-33	interleukin 1 beta	Mus musculus	105-114
19179618-0	2009	Interleukin-1beta contributes via nitric oxide to the upregulation and functional activity of the zinc transporter Zip14 (Slc39a14) in murine hepatocytes.	Nitric Oxide	34-46	interleukin 1 beta	Mus musculus	0-17
18931327-5	2009	In C57Bl/6 mice, acute smoke-mediated increases in inflammatory cells, serum IL-1beta, and serum TNF-alpha were blocked by z-VAD-fmk, a pan-caspase inhibitor, or z-WEHD-fmk, a caspase-1 (IL-1-converting enzyme, [ICE]) inhibitor.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	123-132	interleukin 1 beta	Mus musculus	77-85
19365035-6	2009	Chitosan-NAC formulations, fluorometholone, and artificial tears significantly decreased IL-1beta (interleukin 1beta), IL-10, IL-12alpha, and tumor necrosis factor alpha expression in ocular surface tissues.	Chitosan	0-8	interleukin 1 beta	Mus musculus	89-97
19365035-6	2009	Chitosan-NAC formulations, fluorometholone, and artificial tears significantly decreased IL-1beta (interleukin 1beta), IL-10, IL-12alpha, and tumor necrosis factor alpha expression in ocular surface tissues.	Chitosan	0-8	interleukin 1 beta	Mus musculus	99-116
19365035-6	2009	Chitosan-NAC formulations, fluorometholone, and artificial tears significantly decreased IL-1beta (interleukin 1beta), IL-10, IL-12alpha, and tumor necrosis factor alpha expression in ocular surface tissues.	Fluorometholone	27-42	interleukin 1 beta	Mus musculus	89-97
19365035-6	2009	Chitosan-NAC formulations, fluorometholone, and artificial tears significantly decreased IL-1beta (interleukin 1beta), IL-10, IL-12alpha, and tumor necrosis factor alpha expression in ocular surface tissues.	Fluorometholone	27-42	interleukin 1 beta	Mus musculus	99-116
19407980-4	2009	TSA significantly decreased the mRNA and protein levels of the proinflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta, whereas the pretreatment with TSA increased the level of the immunosuppressive cytokine IL-10.	trichostatin A	0-3	interleukin 1 beta	Mus musculus	157-165
18827741-10	2009	Losartan treatment significantly attenuated TNF-alpha, IL-6, and IL-1beta 6 h after CLP.	Losartan	0-8	interleukin 1 beta	Mus musculus	65-73
19342666-1	2009	Using IL-1/IL-1Ra knockout BALB/c mice, we showed that 3-methylcholatrene (3-MCA)-induced carcinogenesis is dependent on IL-1beta-induced inflammatory responses.	3-methylcholatrene	55-73	interleukin 1 beta	Mus musculus	121-129
19342666-1	2009	Using IL-1/IL-1Ra knockout BALB/c mice, we showed that 3-methylcholatrene (3-MCA)-induced carcinogenesis is dependent on IL-1beta-induced inflammatory responses.	Methylcholanthrene	75-80	interleukin 1 beta	Mus musculus	121-129
19214726-0	2009	Inhalation of carbon monoxide ameliorates collagen-induced arthritis in mice and regulates the articular expression of IL-1beta and MCP-1.	Carbon Monoxide	14-29	interleukin 1 beta	Mus musculus	119-127
19704950-0	2009	Effect of plasma lipoproteins and their complexes with polysaccharides on interleukin-1beta concentration in macrophages of mice with HA-1 ascitic hepatoma.	Polysaccharides	55-70	interleukin 1 beta	Mus musculus	74-91
19704950-4	2009	Addition of polysaccharides in combination with lipoproteins was followed by a 2-3-fold decrease in interleukin-1beta concentration.	Polysaccharides	12-27	interleukin 1 beta	Mus musculus	100-117
19049811-5	2009	The neuroprotective effect of nimodipine was attributed to the inhibition of microglial activation, since nimodipine significantly inhibited the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and prostaglandin E(2) (PGE(2)) from LPS-stimulated microglia.	Nimodipine	30-40	interleukin 1 beta	Mus musculus	219-236
19066339-10	2009	sFas expression also attenuated Dox-mediated induction of proinflammatory cytokines, tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 in the myocardium.	Doxorubicin	32-35	interleukin 1 beta	Mus musculus	114-136
19505382-5	2009	ASBG (12.5-100micorg/animal) exposure Induced neutrophilic lung inflammation with an enhanced local expression of proinflammatory cytokines such as interleukin (IL)-1beta and chemokines such as macrophage inflammatory protein -1a, and keratinocyte-derived chemoattractant in a dose-dependent fashion with overall trends.	asbg	0-4	interleukin 1 beta	Mus musculus	148-170
19184347-6	2009	A considerable reduction in the cytokine and chemokine production, mostly TNFalpha, IL-1beta and IL-6 production in the MPM-treated group, suggested an inhibition of the mediators responsible for leukocyte extravasation.	mpm	120-123	interleukin 1 beta	Mus musculus	84-92
19213858-7	2009	The ex-vivo interferon-gamma and interleukin (IL)-4 production from splenocytes and tumour necrosis factor-alpha and IL-1beta production from peritoneal exudate cells were also significantly lower in the ASEA group compared with the control.	asea	204-208	interleukin 1 beta	Mus musculus	117-125
19049811-5	2009	The neuroprotective effect of nimodipine was attributed to the inhibition of microglial activation, since nimodipine significantly inhibited the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and prostaglandin E(2) (PGE(2)) from LPS-stimulated microglia.	Nimodipine	30-40	interleukin 1 beta	Mus musculus	238-246
19049811-5	2009	The neuroprotective effect of nimodipine was attributed to the inhibition of microglial activation, since nimodipine significantly inhibited the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and prostaglandin E(2) (PGE(2)) from LPS-stimulated microglia.	Nimodipine	106-116	interleukin 1 beta	Mus musculus	219-236
19049811-5	2009	The neuroprotective effect of nimodipine was attributed to the inhibition of microglial activation, since nimodipine significantly inhibited the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and prostaglandin E(2) (PGE(2)) from LPS-stimulated microglia.	Nimodipine	106-116	interleukin 1 beta	Mus musculus	238-246
19135030-2	2009	Amino-acid sequencing analysis reveals that meprin A and meprin alpha cleave pro-IL-1beta at the His(115)-Asp(116) bond, which is one amino acid N-terminal to the caspase-1 cleavage site and five amino acids C-terminal to the meprin beta site.	Histidine	97-100	interleukin 1 beta	Mus musculus	81-89
19145554-0	2009	Ginsenoside Rp1, a ginsenoside derivative, blocks lipopolysaccharide-induced interleukin-1beta production via suppression of the NF-kappaB pathway.	Ginsenosides	0-11	interleukin 1 beta	Mus musculus	77-94
19145554-0	2009	Ginsenoside Rp1, a ginsenoside derivative, blocks lipopolysaccharide-induced interleukin-1beta production via suppression of the NF-kappaB pathway.	Ginsenosides	19-30	interleukin 1 beta	Mus musculus	77-94
19135030-2	2009	Amino-acid sequencing analysis reveals that meprin A and meprin alpha cleave pro-IL-1beta at the His(115)-Asp(116) bond, which is one amino acid N-terminal to the caspase-1 cleavage site and five amino acids C-terminal to the meprin beta site.	Aspartic Acid	106-109	interleukin 1 beta	Mus musculus	81-89
19101514-6	2009	The present findings demonstrate that IL-1alpha and IL-1beta are positive regulators for the Cyp7a1 gene in steady-state mice and that Cyp7a1 is one of the factors that mediate the difference in serum total cholesterol level between sexes.	Cholesterol	207-218	interleukin 1 beta	Mus musculus	52-60
19095037-6	2009	In the applied tests, EO-CO significantly inhibited lipopolysaccharide (LPS)-induced secretion of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), in RAW 264.7 cells, a mouse macrophage-like cell line.	eo-co	22-27	interleukin 1 beta	Mus musculus	180-197
19121625-3	2009	The incubation of RAW264.7 cells with curcumin dose-dependently inhibited the stimulatory responses of macrophage triggered by lipopolysaccharide; the enhanced secretion of inflammatory cytokines such as TNF-alpha and IL-1beta and the up-regulated expression of surface antigens like CD14 and CD40.	Curcumin	38-46	interleukin 1 beta	Mus musculus	218-226
19114896-13	2009	MEASUREMENTS AND MAIN RESULTS: Methyllycaconitine significantly antagonized the beneficial effect of anisodamine on mean arterial pressure and TNF-alpha, interleukin-1beta expression in response to LPS.	methyllycaconitine	31-49	interleukin 1 beta	Mus musculus	154-171
19114896-13	2009	MEASUREMENTS AND MAIN RESULTS: Methyllycaconitine significantly antagonized the beneficial effect of anisodamine on mean arterial pressure and TNF-alpha, interleukin-1beta expression in response to LPS.	anisodamine	101-112	interleukin 1 beta	Mus musculus	154-171
19117633-5	2009	ONO-1714 significantly reduced cytokine-mediated cytotoxicity and NO production in both MIN6N9a cells and C57BL/6 islets in the presence of IL-1beta, TNF-alpha, and IFN-gamma.	7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane	0-8	interleukin 1 beta	Mus musculus	140-148
19095037-6	2009	In the applied tests, EO-CO significantly inhibited lipopolysaccharide (LPS)-induced secretion of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), in RAW 264.7 cells, a mouse macrophage-like cell line.	eo-co	22-27	interleukin 1 beta	Mus musculus	199-207
19164858-6	2009	By activating caspase-1, the enzyme responsible for generating mature IL-1beta and IL-18 from pro-IL-1beta and pro-IL-18, respectively, the Nalp3 inflammasome plays a crucial role in the second step of proinflammatory cytokine activation following acetaminophen-induced liver injury.	Acetaminophen	248-261	interleukin 1 beta	Mus musculus	70-78
19050899-6	2009	Intrarectal treatment of TNBS in mice caused colon shortening and also increased colonic expression of IL-1beta, IL-6, and TNF-alpha expression.	Trinitrobenzenesulfonic Acid	25-29	interleukin 1 beta	Mus musculus	103-111
19067146-5	2009	The TNBS treatment caused colon shortening, increased myeloperoxidase activity, induced IL-1beta, TNF-alpha, and IL-6 expression in the colon, activated NF-kappaB, and potentiated the GAG-degrading activities of intestinal microflora.	Trinitrobenzenesulfonic Acid	4-8	interleukin 1 beta	Mus musculus	88-96
19164858-6	2009	By activating caspase-1, the enzyme responsible for generating mature IL-1beta and IL-18 from pro-IL-1beta and pro-IL-18, respectively, the Nalp3 inflammasome plays a crucial role in the second step of proinflammatory cytokine activation following acetaminophen-induced liver injury.	Acetaminophen	248-261	interleukin 1 beta	Mus musculus	98-106
19027002-2	2009	We found that DMAI suppressed the expression of NF-kappaB-responsive genes, such as inducible nitric oxide synthase, cyclooxygenase-2, interleukin-1beta, and tumor necrosis factor-alpha, in lipopolysaccharide (LPS)-stimulated macrophages and endotoxemic mice as well as protected mice against LPS-induced lethality.	desmethylanhydroicaritin	14-18	interleukin 1 beta	Mus musculus	135-152
19204515-8	2009	RESULTS: Tetrandrine suppressed the LPS-induced increase of TNF-alpha, IL-1beta, and HMGB1 secretion by peritoneal macrophages but did not affect the IL-6 and IL-10 concentrations.	tetrandrine	9-20	interleukin 1 beta	Mus musculus	71-79
19204515-10	2009	The LPS-induced increase in serum TNF-alpha, IL-1beta, and HMGB1 concentrations was reduced by tetrandrine treatment administered either 1 hour before or after LPS injection (p &lt; 0.0001).	tetrandrine	95-106	interleukin 1 beta	Mus musculus	45-53
19204515-13	2009	The effects of tetrandrine on LPS-induced endotoxemia might be related to the suppression of TNF-alpha, IL-1beta, and HMGB1 concentrations.	tetrandrine	15-26	interleukin 1 beta	Mus musculus	104-112
19077053-6	2009	Gene expression profiling studies indicated that among approximately 46,000 transcripts tested, the most significantly up-regulated gene by IS was interleukin-1beta (IL-1beta) which was also the most significantly down-regulated gene when DIDS was added to the IS-treated slices.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	239-243	interleukin 1 beta	Mus musculus	147-164
19077053-6	2009	Gene expression profiling studies indicated that among approximately 46,000 transcripts tested, the most significantly up-regulated gene by IS was interleukin-1beta (IL-1beta) which was also the most significantly down-regulated gene when DIDS was added to the IS-treated slices.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	239-243	interleukin 1 beta	Mus musculus	166-174
19077053-6	2009	Gene expression profiling studies indicated that among approximately 46,000 transcripts tested, the most significantly up-regulated gene by IS was interleukin-1beta (IL-1beta) which was also the most significantly down-regulated gene when DIDS was added to the IS-treated slices.	Iodine	140-142	interleukin 1 beta	Mus musculus	147-164
19077053-6	2009	Gene expression profiling studies indicated that among approximately 46,000 transcripts tested, the most significantly up-regulated gene by IS was interleukin-1beta (IL-1beta) which was also the most significantly down-regulated gene when DIDS was added to the IS-treated slices.	Iodine	140-142	interleukin 1 beta	Mus musculus	166-174
19077053-11	2009	We conclude that (i) IS up-regulates TLR2 expression and augments TLR2 signaling, causing over-expression of IL-1beta which leads to cell death and (ii) DIDS blocks IS-induced neuronal injury, at least partially, by suppressing the TLR2 pathway.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	153-157	interleukin 1 beta	Mus musculus	109-117
19077053-11	2009	We conclude that (i) IS up-regulates TLR2 expression and augments TLR2 signaling, causing over-expression of IL-1beta which leads to cell death and (ii) DIDS blocks IS-induced neuronal injury, at least partially, by suppressing the TLR2 pathway.	Iodine	21-23	interleukin 1 beta	Mus musculus	109-117
19765281-7	2009	RESULTS: PIP-18 inhibited sPLA2-IIA production and enzymatic activity, and suppressed production of MMPs in IL-1beta-induced RA and OA SF cells.	pip-18	9-15	interleukin 1 beta	Mus musculus	108-116
18845788-6	2009	Rimonabant decreased lipopolysaccharide (LPS)- and IL1beta-induced proinflammatory gene expression in mouse peritoneal macrophages in vitro as well as thioglycollate-induced recruitment of macrophages in vivo (10 mg/kg, p.o.	Rimonabant	0-10	interleukin 1 beta	Mus musculus	51-58
19001548-10	2009	Finally, proinflammatory cytokines [tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6] increased thymocyte sensitivity to DHC-induced apoptosis through a mechanism involving 11beta-HSD1.	11-dehydrocorticosterone	134-137	interleukin 1 beta	Mus musculus	65-87
19765281-8	2009	Treatment with PIP-18 blocked IL-1beta-induced p38 MAPK phosphorylation and resulted in attenuation of sPLA2-IIA and MMP mRNA transcription in RA SF cells.	pip-18	15-21	interleukin 1 beta	Mus musculus	30-38
18957328-2	2009	Interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) induced iNOS gene expression and NO production, although these actions were inhibited by L-NG-monomethylarginine (L-NMMA) and decreased alkaline phosphatase (ALPase) activity.	omega-N-Methylarginine	162-185	interleukin 1 beta	Mus musculus	0-17
18957328-2	2009	Interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) induced iNOS gene expression and NO production, although these actions were inhibited by L-NG-monomethylarginine (L-NMMA) and decreased alkaline phosphatase (ALPase) activity.	omega-N-Methylarginine	162-185	interleukin 1 beta	Mus musculus	19-27
18957328-2	2009	Interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) induced iNOS gene expression and NO production, although these actions were inhibited by L-NG-monomethylarginine (L-NMMA) and decreased alkaline phosphatase (ALPase) activity.	omega-N-Methylarginine	187-193	interleukin 1 beta	Mus musculus	0-17
18957328-2	2009	Interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) induced iNOS gene expression and NO production, although these actions were inhibited by L-NG-monomethylarginine (L-NMMA) and decreased alkaline phosphatase (ALPase) activity.	omega-N-Methylarginine	187-193	interleukin 1 beta	Mus musculus	19-27
19050619-15	2009	The degree of staining for nitrotyrosine, inducible nitric oxide synthase, poly (ADP-ribose), tumor necrosis factor-alpha, and interleukin-1beta were markedly reduced in tissue sections obtained from zymosan-injected mice, which had received EP.	Zymosan	200-207	interleukin 1 beta	Mus musculus	127-144
19242063-1	2009	OBJECTIVE: We studied the relationship between the severity of inflammation and IL-1beta production and relative expression level of IL-1beta mRNA in irrigation fluid and synovial tissue obtained from the knee joint during the acute stage of a murine model of type II collagen antibody-induced arthritis (CAIA).	caia	305-309	interleukin 1 beta	Mus musculus	133-141
19215802-6	2009	Enhanced transcription of iNOS, TNF-alpha, IL-1beta, IL-12 and IFN-gamma genes in cisplatin-pretreated macrophages were observed between 12 and 24h of co-incubation with L929 cells.	Cisplatin	82-91	interleukin 1 beta	Mus musculus	43-51
19002106-1	2009	Acetaminophen (APAP) induced increases in intrahepatic expression of interleukin (IL)-1 alpha, IL-1 beta, and IL-1 receptor antagonist (IL-1ra), when administered intraperitoneally.	Acetaminophen	0-13	interleukin 1 beta	Mus musculus	95-104
18804475-8	2009	In vivo, rSj16 dramatically suppressed the recruitment of thioglycollate-mediated leukocytes to the peritoneal cavity of BALB/c mice, accompanied by marked up-regulation of IL-10 and IL-1RA transcripts, and down-regulation of IL-12p35, IL-1 beta and MIP-2 transcripts in peritoneal cells.	rsj16	9-14	interleukin 1 beta	Mus musculus	236-245
19215802-4	2009	Macrophages pretreated with cisplatin for 2h, and co-incubated with L929 cells, produced enhanced NO, TNF-alpha, IL-1beta, IL-12 and IFN-gamma.	Cisplatin	28-37	interleukin 1 beta	Mus musculus	113-121
19215802-4	2009	Macrophages pretreated with cisplatin for 2h, and co-incubated with L929 cells, produced enhanced NO, TNF-alpha, IL-1beta, IL-12 and IFN-gamma.	Deuterium	42-44	interleukin 1 beta	Mus musculus	113-121
20077215-5	2009	In addition, TBBPA increased the secretion and mRNA levels of proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta.	tetrabromobisphenol A	13-18	interleukin 1 beta	Mus musculus	155-163
19002106-1	2009	Acetaminophen (APAP) induced increases in intrahepatic expression of interleukin (IL)-1 alpha, IL-1 beta, and IL-1 receptor antagonist (IL-1ra), when administered intraperitoneally.	Acetaminophen	15-19	interleukin 1 beta	Mus musculus	95-104
19325908-0	2009	Cysteine redox potential determines pro-inflammatory IL-1beta levels.	Cysteine	0-8	interleukin 1 beta	Mus musculus	53-61
20204061-0	2009	IL-1beta suppresses the formation of osteoclasts by increasing OPG production via an autocrine mechanism involving celecoxib-related prostaglandins in chondrocytes.	Celecoxib	115-124	interleukin 1 beta	Mus musculus	0-8
20204061-0	2009	IL-1beta suppresses the formation of osteoclasts by increasing OPG production via an autocrine mechanism involving celecoxib-related prostaglandins in chondrocytes.	Prostaglandins	133-147	interleukin 1 beta	Mus musculus	0-8
20204061-2	2009	Previously, we showed that IL-1beta stimulated the expression of prostaglandin (PG) receptor EP4 via increased PGE(2) production.	Prostaglandins E	111-114	interleukin 1 beta	Mus musculus	27-35
20204061-6	2009	Celecoxib blocked the stimulatory effect of IL-1beta.	Celecoxib	0-9	interleukin 1 beta	Mus musculus	44-52
20204061-8	2009	These results suggest that IL-1beta suppresses the formation of osteoclast-like cells via increased OPG production and decreased M-CSF production in chondrocytes, and OPG production may increase through an autocrine mechanism involving celecoxib-related PGs.	Phosphatidylglycerols	254-257	interleukin 1 beta	Mus musculus	27-35
19662581-3	2009	This work aimed to investigate the in vivo effect of a water extract of lemongrass on pro-inflammatory cytokine (IL-1beta and IL-6) production by macrophages of BALB/c mice.	Water	55-60	interleukin 1 beta	Mus musculus	113-121
19662581-6	2009	Treatment of mice with water extract of lemongrass inhibited macrophages to produce IL-1beta but induced IL-6 production by these cells.	Water	23-28	interleukin 1 beta	Mus musculus	84-92
19190733-7	2009	The BTX-B injected mice mRNA expression levels of TNF-alpha and IL-1beta from conjunctival and corneal epithelial cells increased significantly at two early time points comparing with that of normal and saline injected mice, but IL-1beta returned to normal levels at the 4 week time point.	btx-b	4-9	interleukin 1 beta	Mus musculus	64-72
19190733-10	2009	CONCLUSIONS: BTX-B induced mouse model showed decreased aqueous tear production, increased corneal fluorescein staining, and TNF-alpha and IL-1beta increased expression on the ocular surface within one month.	btx-b	13-18	interleukin 1 beta	Mus musculus	139-147
19325908-3	2009	METHODOLOGY/PRINCIPAL FINDINGS: The purpose of the present study was to determine whether oxidized E(h) Cys/CySS is a determinant of interleukin (IL)-1beta levels.	Cysteine	104-107	interleukin 1 beta	Mus musculus	133-155
19325908-3	2009	METHODOLOGY/PRINCIPAL FINDINGS: The purpose of the present study was to determine whether oxidized E(h) Cys/CySS is a determinant of interleukin (IL)-1beta levels.	cyss	108-112	interleukin 1 beta	Mus musculus	133-155
19325908-4	2009	Results showed a 1.7-fold increase in secreted pro-IL-1beta levels in U937 monocytes exposed to oxidized E(h) Cys/CySS (-46 mV), compared to controls exposed to a physiological E(h) of -80 mV (P&lt;0.01).	Cysteine	110-113	interleukin 1 beta	Mus musculus	51-59
19325908-4	2009	Results showed a 1.7-fold increase in secreted pro-IL-1beta levels in U937 monocytes exposed to oxidized E(h) Cys/CySS (-46 mV), compared to controls exposed to a physiological E(h) of -80 mV (P&lt;0.01).	cyss	114-118	interleukin 1 beta	Mus musculus	51-59
19325908-5	2009	In LPS-challenged mice, preservation of plasma E(h) Cys/CySS from oxidation by dietary sulfur amino acid (SAA) supplementation, was associated with a 1.6-fold decrease in plasma IL-1beta compared to control mice fed an isonitrogenous SAA-adequate diet (P&lt;0.01).	Cysteine	52-55	interleukin 1 beta	Mus musculus	178-186
19325908-5	2009	In LPS-challenged mice, preservation of plasma E(h) Cys/CySS from oxidation by dietary sulfur amino acid (SAA) supplementation, was associated with a 1.6-fold decrease in plasma IL-1beta compared to control mice fed an isonitrogenous SAA-adequate diet (P&lt;0.01).	Amino Acids, Sulfur	87-104	interleukin 1 beta	Mus musculus	178-186
19325908-5	2009	In LPS-challenged mice, preservation of plasma E(h) Cys/CySS from oxidation by dietary sulfur amino acid (SAA) supplementation, was associated with a 1.6-fold decrease in plasma IL-1beta compared to control mice fed an isonitrogenous SAA-adequate diet (P&lt;0.01).	Amino Acids, Sulfur	106-109	interleukin 1 beta	Mus musculus	178-186
19325908-7	2009	CONCLUSIONS/SIGNIFICANCE: These data show that oxidized extracellular E(h) Cys/CySS is a determinant of IL-1beta levels, and suggest that strategies to preserve E(h) Cys/CySS may represent a means to control IL-1beta in inflammatory disease states.	Cysteine	75-78	interleukin 1 beta	Mus musculus	104-112
19325908-7	2009	CONCLUSIONS/SIGNIFICANCE: These data show that oxidized extracellular E(h) Cys/CySS is a determinant of IL-1beta levels, and suggest that strategies to preserve E(h) Cys/CySS may represent a means to control IL-1beta in inflammatory disease states.	cyss	79-83	interleukin 1 beta	Mus musculus	104-112
18929619-11	2008	Exposure to anatase TiO(2) particles also produced higher inflammation responses, in association with the significantly increased tumor necrosis factor alpha (TNF-alpha) and interleukin (IL-1 beta) levels.	titanium dioxide	20-26	interleukin 1 beta	Mus musculus	187-196
18929556-3	2008	In addition, Ikarisoside A reduced the release of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta).	Ikarisoside A	13-26	interleukin 1 beta	Mus musculus	130-148
18929556-3	2008	In addition, Ikarisoside A reduced the release of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta).	Ikarisoside A	13-26	interleukin 1 beta	Mus musculus	150-159
18951870-5	2008	Depletion of macrophages by a bisphosphonate encapsulated in liposomes inhibited this IL-1beta-induced lymphangiogenesis and also up-regulation of VEGF-A, VEGF-C, and VEGF-D.	Diphosphonates	30-44	interleukin 1 beta	Mus musculus	86-94
18952671-4	2008	We show here that EEG seizures induced by intrahippocampal injection of kainic acid in C57BL6 adult mice were increased by 2-fold on average by pre-exposure to IL-1beta and this effect was blocked by 3-O-methylsphingomyelin (3-O-MS), a selective inhibitor of the ceramide-producing enzyme sphingomyelinase.	Kainic Acid	72-83	interleukin 1 beta	Mus musculus	160-168
18952671-4	2008	We show here that EEG seizures induced by intrahippocampal injection of kainic acid in C57BL6 adult mice were increased by 2-fold on average by pre-exposure to IL-1beta and this effect was blocked by 3-O-methylsphingomyelin (3-O-MS), a selective inhibitor of the ceramide-producing enzyme sphingomyelinase.	3-O-methylsphingomyelin	200-223	interleukin 1 beta	Mus musculus	160-168
18952671-4	2008	We show here that EEG seizures induced by intrahippocampal injection of kainic acid in C57BL6 adult mice were increased by 2-fold on average by pre-exposure to IL-1beta and this effect was blocked by 3-O-methylsphingomyelin (3-O-MS), a selective inhibitor of the ceramide-producing enzyme sphingomyelinase.	Ceramides	263-271	interleukin 1 beta	Mus musculus	160-168
18586856-0	2008	In vivo vitamin E administration attenuates interleukin-6 and interleukin-1beta responses to an acute inflammatory insult in mouse skeletal and cardiac muscle.	Vitamin E	8-17	interleukin 1 beta	Mus musculus	62-79
18586856-2	2008	These experiments tested the hypothesis that vitamin E administration attenuates nuclear factor kappaB (NF-kappaB), IL-6, IL-1beta and tumour necrosis factor alpha (TNFalpha) responses in skeletal and cardiac muscle to an inflammatory challenge induced by systemic LPS.	Vitamin E	45-54	interleukin 1 beta	Mus musculus	122-130
18586856-6	2008	Lipopolysaccharide-induced levels of cardiac IL-1beta mRNA and protein and skeletal IL-1beta mRNA were lower with vitamin E than placebo.	Vitamin E	114-123	interleukin 1 beta	Mus musculus	45-53
18586856-6	2008	Lipopolysaccharide-induced levels of cardiac IL-1beta mRNA and protein and skeletal IL-1beta mRNA were lower with vitamin E than placebo.	Vitamin E	114-123	interleukin 1 beta	Mus musculus	84-92
18586856-8	2008	Vitamin E decreased LPS-induced increases in plasma IL-1beta but not IL-6 compared with placebo.	Vitamin E	0-9	interleukin 1 beta	Mus musculus	52-60
18586856-9	2008	The major results provide the first in vivo evidence that short-term vitamin E administration reduces IL-6 and IL-1beta responses to LPS in skeletal and cardiac muscle and prevents LPS-induced increases in NF-kappaB activation and total oxidized proteins.	Vitamin E	69-78	interleukin 1 beta	Mus musculus	111-119
18989766-6	2008	Mice treated with LPS alone showed markedly increased plasma levels of TNF-alpha, IL-1beta, IL-6 and IL-10, whereas mice pretreated with 20 mg/kg ceftiofur showed significantly decreased plasma levels of TNF-alpha, IL-1beta and IL-6, but increased plasma levels of IL-10.	ceftiofur	146-155	interleukin 1 beta	Mus musculus	215-223
19023541-5	2008	In Raw 264.7 cells activated with IFN-gamma/LPS, pre-treated tectorigenin was found to inhibit the expression of inducible nitric oxide synthase (iNOS), the production of nitric oxide (NO) and the secretion of interleukin (IL)-1beta dose-dependently.	tectorigenin	61-73	interleukin 1 beta	Mus musculus	210-232
18989766-6	2008	Mice treated with LPS alone showed markedly increased plasma levels of TNF-alpha, IL-1beta, IL-6 and IL-10, whereas mice pretreated with 20 mg/kg ceftiofur showed significantly decreased plasma levels of TNF-alpha, IL-1beta and IL-6, but increased plasma levels of IL-10.	ceftiofur	146-155	interleukin 1 beta	Mus musculus	82-90
18661234-3	2008	Cuprizone-induced demyelination was accompanied by increased expression of inflammatory cytokines, TNFalpha and IL-1beta, anti-inflammatory cytokines TGFbeta, IL-10 and increased levels of chemokines, CCL2, CCL5, and CXCL10, produced by resident microglia and astrocytes.	Cuprizone	0-9	interleukin 1 beta	Mus musculus	112-120
18812251-1	2008	We showed previously and we confirm here that macrophages from three mouse strains are differentially sensitive to the inhibition of expression of key inflammatory proteins (iNOS-II, IL-1 beta) by dexamethasone, a specific glucocorticoid receptor agonist (C57BL/6&gt;DBA/2&gt;BALB/c).	Dexamethasone	197-210	interleukin 1 beta	Mus musculus	183-192
18786164-8	2008	Spiperone attenuated the expression of inducible nitric oxide synthase and proinflammatory cytokines such as interleukin-1beta and tumor necrosis factor-alpha at mRNA levels in BV-2 microglia cells.	Spiperone	0-9	interleukin 1 beta	Mus musculus	109-158
18461018-7	2008	Inability to signal through the CD14/TLR4 pathway (induced by CD14/KO or inhibition of CD14 expression by administration of geldanamycin) attenuated TNF-alpha, IL-1 beta, and IL-6 production in response to burn injury and improved postburn myocardial contractile function.	geldanamycin	124-136	interleukin 1 beta	Mus musculus	160-169
18849965-9	2008	Mice lacking Atg16L1 in haematopoietic cells are highly susceptible to dextran sulphate sodium-induced acute colitis, which is alleviated by injection of anti-IL-1beta and IL-18 antibodies, indicating the importance of Atg16L1 in the suppression of intestinal inflammation.	dextran sulphate sodium	71-94	interleukin 1 beta	Mus musculus	159-167
18819987-7	2008	Similarly, neurons in organotypic hippocampal slice cultures (OHSCs) from LysM-Cre/Ikkbeta(F/F) mouse brain were less susceptible to KA-induced excitotoxicity compared with wild-type OHSCs, due in part to decreased TNF-alpha and IL-1beta expression.	ohscs	62-67	interleukin 1 beta	Mus musculus	229-237
18823978-6	2008	In contrast, this inhibitory effect was abolished in IL-1beta-stimulated peritoneal macrophages isolated from PPARalpha(-/-) mice and treated with the PPARalpha agonist, GW647.	gw647	170-175	interleukin 1 beta	Mus musculus	53-61
18372199-8	2008	Hypernociception induced by IL-1beta in immunized mice was inhibited by indomethacin, whereas KC/CXCL1-induced hypernociception was inhibited by indomethacin and guanethidine.	Indomethacin	72-84	interleukin 1 beta	Mus musculus	28-36
18927410-7	2008	Exogenous alpha-galactosylceramide, a ligand of NKT cells, induced IL-12 and gamma interferon at 6 h, but suppressed IL-1beta at later time points in wild-type, whereas no effects were evident in Jalpha281 KO mice, as expected.	alpha-galactosylceramide	10-34	interleukin 1 beta	Mus musculus	117-125
18509359-5	2008	In a short-term experiment, pretreatment of IL-12 KO mice with rIL-12 (50 ng per mouse) before each exposure to UVB increased the repair rate of UVB-induced cyclobutane pyrimidine dimers, while inhibiting UVB-induced increases in myeloperoxidase, COX-2, PGE2, PCNA, TNF-alpha, and IL-1beta in the skin as compared with non-rIL-12-treated IL-12 KO mice.	ril-12	63-69	interleukin 1 beta	Mus musculus	281-289
18985016-4	2008	The levels of TNF-alpha, IL-1beta, IL-6 and iNOS mRNAs determined by RT-PCR propose that the inhibition of these pro-inflammatory mediators by KBH-A42 resulted from inhibiting expression of these genes.	KBH A42	143-150	interleukin 1 beta	Mus musculus	25-33
18957167-4	2008	Dendritic cells exposed to lipopolysaccharide, lipoteichoic acid or interleukin (IL)-1beta exhibited increased production of IL-12 p70 and tumour necrosis factor alpha, increased formation of reactive oxygen species (ROS) and nitric oxide (NO), and elevation of intracellular Ca2+ levels.	Reactive Oxygen Species	192-215	interleukin 1 beta	Mus musculus	68-90
18957167-4	2008	Dendritic cells exposed to lipopolysaccharide, lipoteichoic acid or interleukin (IL)-1beta exhibited increased production of IL-12 p70 and tumour necrosis factor alpha, increased formation of reactive oxygen species (ROS) and nitric oxide (NO), and elevation of intracellular Ca2+ levels.	Reactive Oxygen Species	217-220	interleukin 1 beta	Mus musculus	68-90
18957167-4	2008	Dendritic cells exposed to lipopolysaccharide, lipoteichoic acid or interleukin (IL)-1beta exhibited increased production of IL-12 p70 and tumour necrosis factor alpha, increased formation of reactive oxygen species (ROS) and nitric oxide (NO), and elevation of intracellular Ca2+ levels.	Nitric Oxide	226-238	interleukin 1 beta	Mus musculus	68-90
18957167-5	2008	Treatment with taxifolin glycoside inhibited responses stimulated by the microbial products or IL-1beta in dendritic cells in a dose-dependent manner.	taxifolin glycoside	15-34	interleukin 1 beta	Mus musculus	95-103
18957167-7	2008	The results show that taxifolin glycoside seems to inhibit the dendritic cell responses stimulated by microbial products and IL-1beta, suggesting that taxifolin glycoside may exert an inhibitory effect against dendritic-cell-mediated immune responses.	taxifolin glycoside	22-41	interleukin 1 beta	Mus musculus	125-133
18957167-7	2008	The results show that taxifolin glycoside seems to inhibit the dendritic cell responses stimulated by microbial products and IL-1beta, suggesting that taxifolin glycoside may exert an inhibitory effect against dendritic-cell-mediated immune responses.	taxifolin glycoside	151-170	interleukin 1 beta	Mus musculus	125-133
18771711-3	2008	injections of glutamate, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1 beta) significantly increased pCaMKIIalpha expression in the hippocampus, but i.p.	Glutamic Acid	14-23	interleukin 1 beta	Mus musculus	89-98
18991854-3	2008	Therefore, in the present work we evaluated the effect of an acute administration of METH (30 mg/kg in a single intraperitoneal injection) on the interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha mRNA expression levels in the hippocampus, frontal cortex, and striatum of mice.	Methamphetamine	85-89	interleukin 1 beta	Mus musculus	146-168
18855984-11	2008	Mucosal mRNA expression for interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) were found to be markedly reduced in FR167653-treated DSS mice.	Dextran Sulfate	155-158	interleukin 1 beta	Mus musculus	28-45
18855984-11	2008	Mucosal mRNA expression for interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) were found to be markedly reduced in FR167653-treated DSS mice.	Dextran Sulfate	155-158	interleukin 1 beta	Mus musculus	47-55
18782272-9	2008	Interestingly, necrotic cell-induced secretion of TNF-alpha and IL-1beta was also inhibited by methyl-beta-cyclodextrin, thus suggesting a role for lipid rafts in the signalling of this particular inflammatory response.	methyl-beta-cyclodextrin	95-119	interleukin 1 beta	Mus musculus	64-72
19262158-0	2008	Cyclosporin A inhibits CD11a/CD18 adhesion molecules due to inhibition of TNFalpha and IL-1 beta levels in the mouse model of pleurisy induced by carrageenan.	Cyclosporine	0-13	interleukin 1 beta	Mus musculus	87-96
19262158-0	2008	Cyclosporin A inhibits CD11a/CD18 adhesion molecules due to inhibition of TNFalpha and IL-1 beta levels in the mouse model of pleurisy induced by carrageenan.	Carrageenan	146-157	interleukin 1 beta	Mus musculus	87-96
19262158-6	2008	It is our hypothesis that the inhibitory effect elicited by CsA upon these adhesion molecules may be also be attributed to the downregulation of TNFalpha and IL-1 beta cytokines.	Cyclosporine	60-63	interleukin 1 beta	Mus musculus	158-167
18653784-9	2008	SB225002 reduced neutrophil influx, MPO activity, IL-1beta, MIP-2, and keratinocyte-derived chemokine (KC) levels and the expression of vascular endothelial growth factor, inducible NO synthase, and cyclooxygenase-2 proteins into the colon tissue.	SB 225002	0-8	interleukin 1 beta	Mus musculus	50-58
18723371-2	2008	In this study we describe the therapeutic effects by an IL-1beta antibody to improve glucose control in hyperglycemic mice with diet-induced obesity.	Glucose	85-92	interleukin 1 beta	Mus musculus	56-64
18575457-7	2008	We observed early IL-1beta expression in astrocytes in vivo after MCAo and after oxygen-glucose deprivation in vitro, which might contribute to the ischemic damage.	oxygen-glucose	81-95	interleukin 1 beta	Mus musculus	18-26
18598759-4	2008	Exogenous NO augmented COX-2 protein expression and increased COX-2-dependent PGD(2) generation in response to SCF, IL-10, and IL-1beta, or antigen activation in combination with IL-10 and IL-1beta after sensitization with IgE.	Prostaglandin D2	78-84	interleukin 1 beta	Mus musculus	127-135
18583369-8	2008	In addition, expression of the peroxisome proliferator-activated receptors (PPAR-alpha and PPAR-gamma) and IL-1beta were upregulated significantly in the thymus at a dose of 1 mg PFNA/kg/day.	perfluorononanoic acid	179-183	interleukin 1 beta	Mus musculus	107-115
18786831-3	2008	In this study, quaternized amino glucosamine (QAGlc), a newly synthesized cationic glucosamine (Glc) derivative was found to inhibit LPS-stimulated production of IL-1beta, IL-6, TNF-alpha, and PGE(2) in RAW264.7, mouse macrophages more potently than its starting material Glc.	amino glucosamine	27-44	interleukin 1 beta	Mus musculus	162-170
18786831-3	2008	In this study, quaternized amino glucosamine (QAGlc), a newly synthesized cationic glucosamine (Glc) derivative was found to inhibit LPS-stimulated production of IL-1beta, IL-6, TNF-alpha, and PGE(2) in RAW264.7, mouse macrophages more potently than its starting material Glc.	qaglc	46-51	interleukin 1 beta	Mus musculus	162-170
18786831-3	2008	In this study, quaternized amino glucosamine (QAGlc), a newly synthesized cationic glucosamine (Glc) derivative was found to inhibit LPS-stimulated production of IL-1beta, IL-6, TNF-alpha, and PGE(2) in RAW264.7, mouse macrophages more potently than its starting material Glc.	Glucosamine	33-44	interleukin 1 beta	Mus musculus	162-170
18786831-3	2008	In this study, quaternized amino glucosamine (QAGlc), a newly synthesized cationic glucosamine (Glc) derivative was found to inhibit LPS-stimulated production of IL-1beta, IL-6, TNF-alpha, and PGE(2) in RAW264.7, mouse macrophages more potently than its starting material Glc.	Glucosamine	48-51	interleukin 1 beta	Mus musculus	162-170
18786831-3	2008	In this study, quaternized amino glucosamine (QAGlc), a newly synthesized cationic glucosamine (Glc) derivative was found to inhibit LPS-stimulated production of IL-1beta, IL-6, TNF-alpha, and PGE(2) in RAW264.7, mouse macrophages more potently than its starting material Glc.	Glucosamine	96-99	interleukin 1 beta	Mus musculus	162-170
18620044-3	2008	We found that the non-provitamin A carotenoid, lutein, decreased intracellular H(2)O(2) accumulation by scavenging superoxide and H(2)O(2) and the NF-kappaB-regulated inflammatory genes, iNOS, TNF-alpha, IL-1beta, and cyclooxygenase-2, in lipopolysaccharide (LPS)-stimulated macrophages.	beta Carotene	22-34	interleukin 1 beta	Mus musculus	204-212
18620044-3	2008	We found that the non-provitamin A carotenoid, lutein, decreased intracellular H(2)O(2) accumulation by scavenging superoxide and H(2)O(2) and the NF-kappaB-regulated inflammatory genes, iNOS, TNF-alpha, IL-1beta, and cyclooxygenase-2, in lipopolysaccharide (LPS)-stimulated macrophages.	Carotenoids	35-45	interleukin 1 beta	Mus musculus	204-212
18559654-8	2008	Treatment with oATP or IL-1ra (IL-1beta receptor antagonist) reversed LPS plus BzATP-induced hyporeactivity to PE.	2',3'-dialdehyde ATP	15-19	interleukin 1 beta	Mus musculus	31-39
18620044-3	2008	We found that the non-provitamin A carotenoid, lutein, decreased intracellular H(2)O(2) accumulation by scavenging superoxide and H(2)O(2) and the NF-kappaB-regulated inflammatory genes, iNOS, TNF-alpha, IL-1beta, and cyclooxygenase-2, in lipopolysaccharide (LPS)-stimulated macrophages.	Hydrogen Peroxide	79-87	interleukin 1 beta	Mus musculus	204-212
18768827-2	2008	In this study we show that alum adjuvant induces the release of IL-1beta from macrophages and dendritic cells and that this is abrogated in cells lacking various NALP3 inflammasome components.	alum adjuvant	27-40	interleukin 1 beta	Mus musculus	64-72
18639741-0	2008	Trimethyltin-evoked apoptosis of murine hippocampal granule neurons is accompanied by the expression of interleukin-1beta and interleukin-1 receptor antagonist in cells of ameboid phenotype, the majority of which are NG2-positive.	trimethyltin	0-12	interleukin 1 beta	Mus musculus	104-121
18279557-10	2008	Both EC-M17 and metronidazole reduced colonic IL-12, IL-6, IL-1beta and interferon-gamma.	Metronidazole	16-29	interleukin 1 beta	Mus musculus	59-67
18552204-5	2008	Further, CNS glial and astrocyte-enriched cultures treated with a PAMP followed by an ATP pulse had significantly higher levels of supernatant IL-1beta and IL-33 than cultures receiving any single treatment (PAMP or ATP).	Adenosine Triphosphate	86-89	interleukin 1 beta	Mus musculus	143-151
18559654-8	2008	Treatment with oATP or IL-1ra (IL-1beta receptor antagonist) reversed LPS plus BzATP-induced hyporeactivity to PE.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	79-84	interleukin 1 beta	Mus musculus	31-39
18559654-10	2008	BzATP augmented LPS-induced IL-1beta release and iNOS protein expression, and these effects were also inhibited by oATP.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	0-5	interleukin 1 beta	Mus musculus	28-36
18559654-12	2008	Thus, activation of P2X(7) receptor amplifies LPS-induced hyporeactivity in mouse endothelium-intact aorta, which is associated with IL-1beta-mediated release of nitric oxide by iNOS.	Nitric Oxide	162-174	interleukin 1 beta	Mus musculus	133-141
18598692-7	2008	Both pirfenidone and prednisolone suppressed the increase in lung interleukin (IL)-1beta, IL-6, IL-12p40 and monocyte chemoattractant protein (MCP)-1 levels induced by bleomycin.	pirfenidone	5-16	interleukin 1 beta	Mus musculus	66-88
18675455-5	2008	Several key placental genes that influence placental development and fetal osteogenesis (Hgf, Kitl, IFNalpha4, Ifrd, and IL-1beta) were altered by MNU, and largely normalized by Q.	Methylnitrosourea	147-150	interleukin 1 beta	Mus musculus	121-129
18598692-7	2008	Both pirfenidone and prednisolone suppressed the increase in lung interleukin (IL)-1beta, IL-6, IL-12p40 and monocyte chemoattractant protein (MCP)-1 levels induced by bleomycin.	Prednisolone	21-33	interleukin 1 beta	Mus musculus	66-88
18598692-7	2008	Both pirfenidone and prednisolone suppressed the increase in lung interleukin (IL)-1beta, IL-6, IL-12p40 and monocyte chemoattractant protein (MCP)-1 levels induced by bleomycin.	Bleomycin	168-177	interleukin 1 beta	Mus musculus	66-88
18611916-11	2008	Whereas high-salt treatment markedly increased the expression of inflammatory cytokines (tumor necrosis factor-alpha, interferon-gamma, interleukin (IL)-1 beta and IL-6) in the gastric mucosa, COX-2 overexpression significantly altered the cell kinetics in the MNU-induced gastric cancer model.	Salts	13-17	interleukin 1 beta	Mus musculus	136-159
18524861-9	2008	The effect of IL-1beta on ET-1 release could be partially inhibited by pretreatment of IMCD-3 cells with an inhibitor of NF-kappaB activation (BAY 11-7082).	3-(4-methylphenylsulfonyl)-2-propenenitrile	143-154	interleukin 1 beta	Mus musculus	14-22
18596626-10	2008	Hypercapnic acidosis with 2% respectively 4% CO2 significantly attenuated this increase with 25 +/- 32% and 54 +/- 32% (IL-1beta, p &lt; 0.01); 17 +/- 36% and 58 +/- 33% (TNF-alpha, p &lt; 0.02); 22 +/- 34% and 89 +/- 6% (IL-6, p &lt; 0.01); 20 +/- 31% and 67 +/- 17% (IL-10, p &lt; 0.01) and 16 +/- 44% and 45 +/- 30% (keratocyte-derived chemokine, p = 0.07).	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	45-48	interleukin 1 beta	Mus musculus	120-128
18761814-7	2008	Furthermore, we found that albaconol used at a lower dosage without apoptosis induction could significantly inhibit LPS-induced TNF-alpha, IL-6, IL-1beta and NO production in RAW264.7 cells.	albaconol	27-36	interleukin 1 beta	Mus musculus	145-153
18491079-4	2008	RESULTS: The impact of an acute bolus injection of IL-1beta (1.0 microg) on plasma corticosterone and on circulating IL-1beta, IL-6, and TNF-alpha were diminished following 5-day IL-1beta treatment, although high levels of sickness were still apparent.	Corticosterone	83-97	interleukin 1 beta	Mus musculus	51-59
18650668-9	2008	Tear IL-1 beta increased throughout the 5 days of EDE in WT and KO mice.	Edeine B	50-53	interleukin 1 beta	Mus musculus	5-14
18491079-5	2008	When IL-1beta (1.0 or 2.0 mug/day) was continuously infused over 3 days, plasma corticosterone and sickness were elevated, but these effects were attenuated after 7 days (subchronic) of treatment.	Corticosterone	80-94	interleukin 1 beta	Mus musculus	5-13
18491079-7	2008	Despite the diminution of the behavioral and neuroendocrine effects of the cytokine after treatment 7 days, subchronic IL-1beta infusion altered prefrontal cortical and hippocampal serotonin and norepinephrine utilization, and within these regions, the messenger RNA (mRNA) expression of IL-1beta, IL-6, TNF-alpha, and their receptors, as well as that of 5-HT(2C), 5-HT(1B) receptors, and p11, was increased.	Serotonin	181-190	interleukin 1 beta	Mus musculus	119-127
18491079-7	2008	Despite the diminution of the behavioral and neuroendocrine effects of the cytokine after treatment 7 days, subchronic IL-1beta infusion altered prefrontal cortical and hippocampal serotonin and norepinephrine utilization, and within these regions, the messenger RNA (mRNA) expression of IL-1beta, IL-6, TNF-alpha, and their receptors, as well as that of 5-HT(2C), 5-HT(1B) receptors, and p11, was increased.	Norepinephrine	195-209	interleukin 1 beta	Mus musculus	119-127
18795615-13	2008	IL-1beta, IL-6, and IL-12 secretion of smDC was significantly lower than that of mDC (P &lt; 0.01), and IL-12 was significantly lower than that of iDC (P &lt; 0.05), while no significant difference of IL-1beta and IL-6 secretion was found between smDC and iDC (P &gt; 0.05).	Metam-sodium	39-43	interleukin 1 beta	Mus musculus	0-8
18474228-4	2008	We found that ceftiofur can downregulate tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6), but did not affect interleukin-10 (IL-10) production.	ceftiofur	14-23	interleukin 1 beta	Mus musculus	82-99
18474228-4	2008	We found that ceftiofur can downregulate tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6), but did not affect interleukin-10 (IL-10) production.	ceftiofur	14-23	interleukin 1 beta	Mus musculus	101-109
18538348-0	2008	Strain differences regarding susceptibility to ursolic acid-induced interleukin-1beta release in murine macrophages.	ursolic acid	47-59	interleukin 1 beta	Mus musculus	68-85
18538348-2	2008	We have recently found that aggregated ursolic acid (UA), a triterpene carboxylic acid, is recognized by CD36 for generating reactive oxygen species (ROS) via NADPH oxidase (NOX) activation, thereby releasing IL-1beta protein from murine peritoneal macrophages (pMphi) in female ICR mice.	ursolic acid	39-51	interleukin 1 beta	Mus musculus	209-217
18538348-2	2008	We have recently found that aggregated ursolic acid (UA), a triterpene carboxylic acid, is recognized by CD36 for generating reactive oxygen species (ROS) via NADPH oxidase (NOX) activation, thereby releasing IL-1beta protein from murine peritoneal macrophages (pMphi) in female ICR mice.	ursolic acid	53-55	interleukin 1 beta	Mus musculus	209-217
18538348-2	2008	We have recently found that aggregated ursolic acid (UA), a triterpene carboxylic acid, is recognized by CD36 for generating reactive oxygen species (ROS) via NADPH oxidase (NOX) activation, thereby releasing IL-1beta protein from murine peritoneal macrophages (pMphi) in female ICR mice.	triterpene carboxylic acid	60-86	interleukin 1 beta	Mus musculus	209-217
18538348-2	2008	We have recently found that aggregated ursolic acid (UA), a triterpene carboxylic acid, is recognized by CD36 for generating reactive oxygen species (ROS) via NADPH oxidase (NOX) activation, thereby releasing IL-1beta protein from murine peritoneal macrophages (pMphi) in female ICR mice.	Reactive Oxygen Species	150-153	interleukin 1 beta	Mus musculus	209-217
18538348-3	2008	In the present study, we investigated the ability of UA for inducing IL-1beta production in pMphi from 4 different strains of female mice (C57BL/6J, C3H/He, DDY, and ICR), as well as an established macrophage line (RAW264.7 cells).	ursolic acid	53-55	interleukin 1 beta	Mus musculus	69-77
18538348-4	2008	The levels of IL-1beta released from UA-treated pMphi of C57BL/6J and DDY mice were significantly lower than from those of ICR mice, whereas IL-1beta was not released from the pMphi of C3H/He mice or RAW264.7 cells.	ursolic acid	37-39	interleukin 1 beta	Mus musculus	14-22
18538348-6	2008	In addition, the different susceptibilities to UA-induced IL-1beta release were suggested to be correlated with the amount of superoxide anion (O2-) generated from the 5 different types of Mphi.	ursolic acid	47-49	interleukin 1 beta	Mus musculus	58-66
18441091-5	2008	Pulmonary inflammation was induced in male B6C3F1 mice by intratracheal administration of IL-1beta and TNF-alpha under isoflurane anesthesia.	Isoflurane	119-129	interleukin 1 beta	Mus musculus	90-98
18538348-6	2008	In addition, the different susceptibilities to UA-induced IL-1beta release were suggested to be correlated with the amount of superoxide anion (O2-) generated from the 5 different types of Mphi.	Superoxides	126-142	interleukin 1 beta	Mus musculus	58-66
18538348-6	2008	In addition, the different susceptibilities to UA-induced IL-1beta release were suggested to be correlated with the amount of superoxide anion (O2-) generated from the 5 different types of Mphi.	Superoxides	144-146	interleukin 1 beta	Mus musculus	58-66
18538348-8	2008	Together, our results indicate that the UA-induced IL-1beta release was strain-dependent, and the expression status of CD36 and gp91phox is strongly associated with inducibility.	ursolic acid	40-42	interleukin 1 beta	Mus musculus	51-59
18513703-3	2008	CT20126 suppressed the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2, tumor necrosis factor-alpha, and interleukin-1beta as well as the production of nitric oxide and prostaglandin E(2) in lipopolysaccharide (LPS)-treated macrophages as well as LPS-administered mice.	CT20126	0-7	interleukin 1 beta	Mus musculus	128-145
18486908-5	2008	The pro-inflammatory cytokine production and gene expression of TNF-alpha, IL-1beta, IL-6 and GM-CSF were down regulated in ursolic acid treated cells compared to nontreated B16F-10 metastatic melanoma cells.	ursolic acid	124-136	interleukin 1 beta	Mus musculus	75-83
18383346-4	2008	In our study, we report that a combination of IL-1beta and TNFalpha exerts a synergistic effect on glucose utilization and markedly modifies the metabolic phenotype of astrocytes.	Glucose	99-106	interleukin 1 beta	Mus musculus	46-54
18383346-5	2008	Thus, IL-1beta+TNFalpha treated astrocytes show a marked decrease in glycogen levels, a slight but not significant decrease in lactate release as well as a massive increase in both the pentose phosphate pathway and TCA cycle activities.	Glycogen	69-77	interleukin 1 beta	Mus musculus	6-14
18383346-5	2008	Thus, IL-1beta+TNFalpha treated astrocytes show a marked decrease in glycogen levels, a slight but not significant decrease in lactate release as well as a massive increase in both the pentose phosphate pathway and TCA cycle activities.	Lactic Acid	127-134	interleukin 1 beta	Mus musculus	6-14
18383346-5	2008	Thus, IL-1beta+TNFalpha treated astrocytes show a marked decrease in glycogen levels, a slight but not significant decrease in lactate release as well as a massive increase in both the pentose phosphate pathway and TCA cycle activities.	Pentosephosphates	185-202	interleukin 1 beta	Mus musculus	6-14
18383346-5	2008	Thus, IL-1beta+TNFalpha treated astrocytes show a marked decrease in glycogen levels, a slight but not significant decrease in lactate release as well as a massive increase in both the pentose phosphate pathway and TCA cycle activities.	Trichloroacetic Acid	215-218	interleukin 1 beta	Mus musculus	6-14
18383346-6	2008	Glutamate-stimulated glucose utilization and lactate release, a typical feature of astrocyte energy metabolism, are altered after pretreatment with IL-1beta+TNFalpha.	Glutamic Acid	0-9	interleukin 1 beta	Mus musculus	148-156
18383346-6	2008	Glutamate-stimulated glucose utilization and lactate release, a typical feature of astrocyte energy metabolism, are altered after pretreatment with IL-1beta+TNFalpha.	Glucose	21-28	interleukin 1 beta	Mus musculus	148-156
18383346-6	2008	Glutamate-stimulated glucose utilization and lactate release, a typical feature of astrocyte energy metabolism, are altered after pretreatment with IL-1beta+TNFalpha.	Lactic Acid	45-52	interleukin 1 beta	Mus musculus	148-156
18383346-7	2008	As far as mechanisms for oxidative stress defence are concerned, we observed that treatment with IL-1beta+TNFalpha decreases cellular glutathione content and increases glutathione release into the extracellular space while stimulating superoxide anion and nitric oxide production as well as H(2)O(2) release.	Glutathione	134-145	interleukin 1 beta	Mus musculus	97-105
18383346-7	2008	As far as mechanisms for oxidative stress defence are concerned, we observed that treatment with IL-1beta+TNFalpha decreases cellular glutathione content and increases glutathione release into the extracellular space while stimulating superoxide anion and nitric oxide production as well as H(2)O(2) release.	Glutathione	168-179	interleukin 1 beta	Mus musculus	97-105
18383346-7	2008	As far as mechanisms for oxidative stress defence are concerned, we observed that treatment with IL-1beta+TNFalpha decreases cellular glutathione content and increases glutathione release into the extracellular space while stimulating superoxide anion and nitric oxide production as well as H(2)O(2) release.	Superoxides	235-251	interleukin 1 beta	Mus musculus	97-105
18383346-7	2008	As far as mechanisms for oxidative stress defence are concerned, we observed that treatment with IL-1beta+TNFalpha decreases cellular glutathione content and increases glutathione release into the extracellular space while stimulating superoxide anion and nitric oxide production as well as H(2)O(2) release.	Nitric Oxide	256-268	interleukin 1 beta	Mus musculus	97-105
18383346-7	2008	As far as mechanisms for oxidative stress defence are concerned, we observed that treatment with IL-1beta+TNFalpha decreases cellular glutathione content and increases glutathione release into the extracellular space while stimulating superoxide anion and nitric oxide production as well as H(2)O(2) release.	Hydrogen Peroxide	291-299	interleukin 1 beta	Mus musculus	97-105
18383346-8	2008	Interestingly, stimulation of glucose utilization by IL-1beta+TNFalpha is not affected by the antioxidant N-acetyl-L-cysteine, suggesting that cellular stress does not account for this effect.	Glucose	30-37	interleukin 1 beta	Mus musculus	53-61
18486909-3	2008	We investigated the effects of florfenicol on cytokine production by lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages in vitro, and the results showed that florfenicol reduced tumor necrosis factor (TNF) and interleukin-6 (IL-6) production but had little effect on interleukin-1beta (IL-1beta) and interleukin IL-10 (IL-10) secretion.	florfenicol	165-176	interleukin 1 beta	Mus musculus	274-291
18486909-3	2008	We investigated the effects of florfenicol on cytokine production by lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages in vitro, and the results showed that florfenicol reduced tumor necrosis factor (TNF) and interleukin-6 (IL-6) production but had little effect on interleukin-1beta (IL-1beta) and interleukin IL-10 (IL-10) secretion.	florfenicol	165-176	interleukin 1 beta	Mus musculus	293-301
18417733-4	2008	In both the acute (LPS) and chronic inflammation (Tg2576), TC and curcumin similarly reduced interleukin-1beta.	tetrahydrocurcumin	59-61	interleukin 1 beta	Mus musculus	93-110
18486919-6	2008	As a result, Corilagin could significantly reduce production of pro-inflammatory cytokines and mediators TNF-alpha, IL-1beta, IL-6, NO (iNOS) and COX-2 on both protein and gene level by blocking NF-kappaB nuclear translocation.	corilagin	13-22	interleukin 1 beta	Mus musculus	116-124
18622687-6	2008	Protein and mRNA levels of the pro-inflammatory cytokines IL-6, IL-1beta and TNFalpha in BALF were found to be significantly decreased in GW0742-treated animals (30 mg/kg).	GW0742	138-144	interleukin 1 beta	Mus musculus	64-72
18205183-7	2008	In proximal colon, production of IL-1beta and IL-6 in PACAP-/- mice were significantly upregulated on day 8 after DSS administration, compared to wild-type control mice.	Dextran Sulfate	114-117	interleukin 1 beta	Mus musculus	33-41
18566370-3	2008	We report that in vitro and in vivo conditioning of murine myeloid DC with RAPA elicits the de novo production of IL-1beta by otherwise phenotypically immature DC.	Sirolimus	75-79	interleukin 1 beta	Mus musculus	114-122
18417733-4	2008	In both the acute (LPS) and chronic inflammation (Tg2576), TC and curcumin similarly reduced interleukin-1beta.	Curcumin	66-74	interleukin 1 beta	Mus musculus	93-110
18590825-5	2008	Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by fluid accumulation in the pleural cavity which contained a large number of neutrophils (PMNs) as well as an infiltration of PMNs in lung tissues and subsequent lipid peroxidation (as determinated by thiobarbituric acid-reactant substances measurement) and increased production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	Carrageenan	13-24	interleukin 1 beta	Mus musculus	439-456
18590825-5	2008	Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by fluid accumulation in the pleural cavity which contained a large number of neutrophils (PMNs) as well as an infiltration of PMNs in lung tissues and subsequent lipid peroxidation (as determinated by thiobarbituric acid-reactant substances measurement) and increased production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	Carrageenan	13-24	interleukin 1 beta	Mus musculus	458-466
18435685-8	2008	Leukocytes, lymphocytes, neutrophils, 8-isoprostane and IL-1beta levels after ischaemia and reperfusion were significantly reduced in mice treated with azithromycin.	Azithromycin	152-164	interleukin 1 beta	Mus musculus	56-64
18435685-10	2008	A significant correlation was seen between 8-isoprostanes and neutrophils (Pearson r = 0.72; P = 0.0086), IL-6 (Pearson r = 0.84; P = 0.0006), KC (Pearson r = 0.88; P = 0.0002) and IL-1beta (Pearson r = 0.62; P = 0.0326).	8-epi-prostaglandin F2alpha	43-57	interleukin 1 beta	Mus musculus	181-189
18460899-6	2008	We also found that levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and inducible nitric oxide synthase (iNOS) in the mdx mice were decreased by curcumin administration.	Curcumin	177-185	interleukin 1 beta	Mus musculus	70-88
18460899-6	2008	We also found that levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and inducible nitric oxide synthase (iNOS) in the mdx mice were decreased by curcumin administration.	Curcumin	177-185	interleukin 1 beta	Mus musculus	90-98
18523246-0	2008	Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway.	Lysophospholipids	0-17	interleukin 1 beta	Mus musculus	70-79
18501931-5	2008	IL-1beta significantly reduced levels of fibrillar actin in the cytoskeleton, a pre-requisite for tube formation, as indicated by phalloidin-FITC staining.	Phalloidin-FITC	130-145	interleukin 1 beta	Mus musculus	0-8
17950329-13	2008	CONCLUSIONS: These data suggest that (1) both obesity and dietary carbohydrates increase gallbladder total fat, triglycerides, cholesterol, TNF-alpha, and IL-1beta and (2) obesity also increases gallbladder free fatty acids and IL-6.	Carbohydrates	66-79	interleukin 1 beta	Mus musculus	155-163
18523246-0	2008	Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway.	Adenosine Triphosphate	22-25	interleukin 1 beta	Mus musculus	70-79
18523262-7	2008	Prophylactic administration of SB-331750 to collagen-immunized/boosted DBA/1 mice delayed the onset and reduced the severity of collagen-induced arthritis (CIA), and reduced paw tissue levels of IL-1beta and TNF-alpha.	SB 331750	31-40	interleukin 1 beta	Mus musculus	195-203
18523246-3	2008	In this study, we determined whether the lysophospholipids, i.e., LPC and sphingosylphosphorylcholine (SPC), modulate the ATP-induced release and processing of IL-1beta mediated by P2X7R in mouse MG6 microglial cells.	Lysophospholipids	41-58	interleukin 1 beta	Mus musculus	160-168
18523246-10	2008	In addition, the microtubule inhibitor colchicine inhibited ATP-induced release of mIL-1beta similar to that of LPC and SPC.	Colchicine	39-49	interleukin 1 beta	Mus musculus	83-92
18523246-3	2008	In this study, we determined whether the lysophospholipids, i.e., LPC and sphingosylphosphorylcholine (SPC), modulate the ATP-induced release and processing of IL-1beta mediated by P2X7R in mouse MG6 microglial cells.	Lysophosphatidylcholines	66-69	interleukin 1 beta	Mus musculus	160-168
18523246-10	2008	In addition, the microtubule inhibitor colchicine inhibited ATP-induced release of mIL-1beta similar to that of LPC and SPC.	Adenosine Triphosphate	60-63	interleukin 1 beta	Mus musculus	83-92
18523246-3	2008	In this study, we determined whether the lysophospholipids, i.e., LPC and sphingosylphosphorylcholine (SPC), modulate the ATP-induced release and processing of IL-1beta mediated by P2X7R in mouse MG6 microglial cells.	sphingosine phosphorylcholine	74-101	interleukin 1 beta	Mus musculus	160-168
18523246-11	2008	This suggests that the impairment of the microtubule reassembly may be associated with the inhibitory effects of LPC/SPC on ATP-induced mIL-1beta release.	Adenosine Triphosphate	124-127	interleukin 1 beta	Mus musculus	136-145
18523246-12	2008	Mutual suppression by ATP and LPC/SPC on the maturation of IL-1beta was observed in LPS-primed primary microglia.	Adenosine Triphosphate	22-25	interleukin 1 beta	Mus musculus	59-67
18523246-3	2008	In this study, we determined whether the lysophospholipids, i.e., LPC and sphingosylphosphorylcholine (SPC), modulate the ATP-induced release and processing of IL-1beta mediated by P2X7R in mouse MG6 microglial cells.	Adenosine Triphosphate	122-125	interleukin 1 beta	Mus musculus	160-168
18523246-13	2008	Collectively, these data suggest opposing functions by lysophospholipids, either proinflammatory or anti-inflammatory, in regard to the maturation and release of IL-1beta from microglial cells.	Lysophospholipids	55-72	interleukin 1 beta	Mus musculus	162-170
18523246-5	2008	However, these lysophospholipids inhibited ATP-induced caspase-1 activation that is usually followed by the release of mIL-1beta.	Lysophospholipids	15-32	interleukin 1 beta	Mus musculus	119-128
18523246-5	2008	However, these lysophospholipids inhibited ATP-induced caspase-1 activation that is usually followed by the release of mIL-1beta.	Adenosine Triphosphate	43-46	interleukin 1 beta	Mus musculus	119-128
18523246-6	2008	Conversely, ATP inhibited the release of pro-IL-1beta and mIL-1beta induced by LPC/SPC.	Adenosine Triphosphate	12-15	interleukin 1 beta	Mus musculus	45-53
18523246-6	2008	Conversely, ATP inhibited the release of pro-IL-1beta and mIL-1beta induced by LPC/SPC.	Adenosine Triphosphate	12-15	interleukin 1 beta	Mus musculus	58-67
18523246-7	2008	This suggests that lysophospholipids and ATP mutually suppressed each function to release IL-1beta.	Lysophospholipids	19-36	interleukin 1 beta	Mus musculus	90-98
18523246-7	2008	This suggests that lysophospholipids and ATP mutually suppressed each function to release IL-1beta.	Adenosine Triphosphate	41-44	interleukin 1 beta	Mus musculus	90-98
18433975-6	2008	The functional significance of elevated DON tissue concentrations was assessed by measuring IL-1beta, IL-6, and TNF-alpha mRNA responses in spleen, liver and lung.	deoxynivalenol	40-43	interleukin 1 beta	Mus musculus	92-100
18457905-5	2008	Dietary supplementation with glutamine reversed both the lower concentrations of protein and DNA in the muscle and liver, as well as the reduced capacity of spreading and synthesizing nitric oxide, hydrogen peroxide, TNF-alpha, IL-1 beta and IL-6 in cultures of peritoneal macrophages obtained from the -GLN group (P&lt;0.05).	Glutamine	29-38	interleukin 1 beta	Mus musculus	228-237
18386091-6	2008	However, dietary perilla oil significantly (P &lt; 0.05) reduced proinflammatory cytokine (TNF-alpha, IL-1beta and IL-6) and Th1 cytokine (IFN-gamma and IL-2) production.	perilla seed oil	17-28	interleukin 1 beta	Mus musculus	102-110
18375438-6	2008	Administration of CoPP caused a sustained increase in HO-1 protein, prevented weight gain, decreased visceral and subcutaneous fat content (P &lt; 0.03 and 0.01, respectively, compared with vehicle animals), increased serum adiponectin, and decreased plasma tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and IL-1beta levels (P &lt; 0.05).	COPP protocol	18-22	interleukin 1 beta	Mus musculus	323-331
18427964-6	2008	While dexamethasone (DM) was used as a positive control, the effects of ethanol extract on the production of IL-1beta, IL-6, NO, COX-2 and TNF-alpha, the expression of iNOS mRNA, TNF-alpha mRNA, COX-2 mRNA, protein production of COX-2 and HO-1, NF-kappaB and I-kappaB of LPS-stimulated RAW 264.7 cells were studied by sandwich ELISA, real-time PCR, Western blot analysis and immunocytochemistry assay respectively.	Ethanol	72-79	interleukin 1 beta	Mus musculus	109-117
18427964-13	2008	Schindl ethanol extract might be due to the down-regulation of IL-1beta, IL-6, NO, TNF-alpha and COX-2 via the suppression of NF-kappaB activation and conversation of I-kappaB production, and another pathway was up regulating the production of IL-10 and HO-1.	schindl ethanol	0-15	interleukin 1 beta	Mus musculus	63-71
18442781-6	2008	The results demonstrated upregulation of mRNA islets and downregulation of the serum concentration of IL-1beta, IL-12 and TNF-alpha in the group treated with 5 and 10 mg/kg/day diacerhein, when compared with the saline group, and increased IFN-gamma serum concentration in the group treated with 50 mg/kg/day.	diacerein	177-187	interleukin 1 beta	Mus musculus	102-110
18490713-3	2008	Activation of purinergic P2X(7) receptors (P2X(7)R) by extracellular ATP is a key physiological inducer of rapid IL-1beta release from LPS-primed macrophage.	Adenosine Triphosphate	69-72	interleukin 1 beta	Mus musculus	113-121
18490713-5	2008	We used peritoneal macrophage from P2X(7)R(-/-) mice and found that release of IL-1alpha, IL-18, as well as IL-1beta, by ATP resulted exclusively from activation of P2X(7)R, release of all these IL-1 cytokines involved pannexin-1 (panx1), and that there was both a panx1-dependent and -independent component to IL-1beta release.	Adenosine Triphosphate	121-124	interleukin 1 beta	Mus musculus	108-116
18490713-5	2008	We used peritoneal macrophage from P2X(7)R(-/-) mice and found that release of IL-1alpha, IL-18, as well as IL-1beta, by ATP resulted exclusively from activation of P2X(7)R, release of all these IL-1 cytokines involved pannexin-1 (panx1), and that there was both a panx1-dependent and -independent component to IL-1beta release.	Adenosine Triphosphate	121-124	interleukin 1 beta	Mus musculus	311-319
18490713-8	2008	We delineated two distinct release pathways: the well-known caspase-1 cascade mediating release of processed IL-1beta that was selectively blocked by inhibition of caspase-1 or panx1, and a calcium-independent, caspase-1/panx1-independent release of pro-IL-1beta that was selectively blocked by glycine.	Calcium	190-197	interleukin 1 beta	Mus musculus	109-117
18490713-8	2008	We delineated two distinct release pathways: the well-known caspase-1 cascade mediating release of processed IL-1beta that was selectively blocked by inhibition of caspase-1 or panx1, and a calcium-independent, caspase-1/panx1-independent release of pro-IL-1beta that was selectively blocked by glycine.	Glycine	295-302	interleukin 1 beta	Mus musculus	109-117
18490713-10	2008	This provides the first direct demonstration of a distinct signaling mechanism responsible for ATP-induced release of pro-IL-1beta.	Adenosine Triphosphate	95-98	interleukin 1 beta	Mus musculus	122-130
18831214-4	2008	RESULT: IPS-B2 could not promote mouse peritoneal macrophage production, but it could significantly improve the IL-1beta, IL-6, TNF-alpha content in mouse peritoneal macrophages culture supernatant, and increase the gene expression of IL-1beta, IL-6, TNF-alpha and iNOS.	ips-b2	8-14	interleukin 1 beta	Mus musculus	112-120
18313411-6	2008	HO-1 induction with an adenoviral vector carrying HO-1 showed a decrease in total iNOS protein, nitrite production, and iNOS dimer level from cells stimulated by IL-1beta.	Nitrites	96-103	interleukin 1 beta	Mus musculus	162-170
18516292-6	2008	Corresponding to the aggressive growth, IL-1beta(comp) cells display increased matrix adhesion, motility, and cable formation on matrigel, likely supported by elevated alpha(v)/beta3 and matrix metalloroteinase expression.	metalloroteinase	194-210	interleukin 1 beta	Mus musculus	40-48
18831214-4	2008	RESULT: IPS-B2 could not promote mouse peritoneal macrophage production, but it could significantly improve the IL-1beta, IL-6, TNF-alpha content in mouse peritoneal macrophages culture supernatant, and increase the gene expression of IL-1beta, IL-6, TNF-alpha and iNOS.	ips-b2	8-14	interleukin 1 beta	Mus musculus	235-243
18403674-3	2008	Here, we show that asbestos and silica are sensed by the Nalp3 inflammasome, whose subsequent activation leads to interleukin-1beta secretion.	Silicon Dioxide	32-38	interleukin 1 beta	Mus musculus	114-131
18439853-4	2008	The air-pouch exudate from animals stimulated with calcium hydroxide showed an increase of leukotriene-B(4) (LTB(4)), interleukin-1beta, tumor necrosis factor alpha (TNF-alpha), cytokine-induced neutrophil chemoattractant (KC), and macrophage inflammatory protein 2 (MIP-2) release.	Calcium Hydroxide	51-68	interleukin 1 beta	Mus musculus	118-135
18489773-7	2008	Brain protein levels of IL-1beta, NADPH oxidase subunit p67phox, and phosphorylated-signal transducer and activator of transcription 3 (STAT3) were higher in COX-2-/- and in celecoxib-treated mice, compared to COX-2+/+ mice.	Celecoxib	174-183	interleukin 1 beta	Mus musculus	24-32
18477398-13	2008	Furthermore, the minocycline associated recovery from LPS-induced sickness behavior was paralleled by reduced mRNA levels of Interleukin (IL)-1beta, IL-6, and indoleamine 2, 3 dioxygenase (IDO) in the cortex and hippocampus.	Minocycline	17-28	interleukin 1 beta	Mus musculus	125-147
18477398-14	2008	Finally, in aged mice, where exaggerated neuroinflammation was elicited by LPS, minocycline pretreatment was still effective in markedly reducing mRNA levels of IL-1beta, TLR2 and IDO in the hippocampus.	Minocycline	80-91	interleukin 1 beta	Mus musculus	161-169
18371952-12	2008	Over-expression of cytokines, such as tumor necrosis factor alpha and interleukin 1beta, elevated plasma endotoxin level, and up-regulation of CD14 were also suppressed by bicyclol in alcohol-intoxicated mice.	bicyclol	172-180	interleukin 1 beta	Mus musculus	70-87
18371952-12	2008	Over-expression of cytokines, such as tumor necrosis factor alpha and interleukin 1beta, elevated plasma endotoxin level, and up-regulation of CD14 were also suppressed by bicyclol in alcohol-intoxicated mice.	Alcohols	184-191	interleukin 1 beta	Mus musculus	70-87
18400394-6	2008	CCI led to an early downregulation of TNF and IL-1beta mRNA in distinct brain areas and in the lumbar spinal cord with a maximum decrease within the first 6h after CCI.	CCI	0-3	interleukin 1 beta	Mus musculus	46-54
18194440-0	2008	The inflammatory cytokine, interleukin-1 beta, mediates loss of astroglial glutamate transport and drives excitotoxic motor neuron injury in the spinal cord during acute viral encephalomyelitis.	Glutamic Acid	75-84	interleukin 1 beta	Mus musculus	27-45
18438860-6	2008	Finally, small interfering RNA (siRNA) was used to assess the influence of visfatin on IL-1beta-induced release of PGE2 in immature mouse articular chondrocytes.	Dinoprostone	115-119	interleukin 1 beta	Mus musculus	87-95
18332856-10	2008	Liquiritigenin also suppressed the production of TNF-alpha, IL-1beta and IL-6 from Raw264.7 cells after LPS.	liquiritigenin	0-14	interleukin 1 beta	Mus musculus	60-68
18040755-0	2008	Dose-dependent effects of Ni (II) ions on production of three inflammatory cytokines (TNF-alpha, IL-1beta and IL-6), superoxide dismutase (SOD) and free radical NO by murine macrophage-like RAW264 cells with or without LPS-stimulation.	ni (ii)	26-33	interleukin 1 beta	Mus musculus	97-105
18040755-2	2008	The purpose of this study was to examine the dose-dependent effects of Ni (II) ions up to 1,000 micromol/L on production of three inflammatory cytokines (TNF-alpha, IL-1beta and IL-6), superoxide dismutase (SOD) and nitric oxide (NO) by murine macrophage-like RAW264 cells with (+) or without (-) lipopolysaccharide (LPS) -stimulation.	ni (ii)	71-78	interleukin 1 beta	Mus musculus	165-173
18040755-3	2008	Ni (II) ions caused LPS (-) RAW264 cells to slightly increase production of TNF-alpha and IL-6, proportionally to the Ni (II) ion concentration while IL-1beta was not produced, and to slightly increase production of SOD and NO.	ni (ii)	0-7	interleukin 1 beta	Mus musculus	150-158
18387518-4	2008	Dendritic cells exposed to lipopolysaccharide, lipoteichoic acid and IL-1beta exhibited increase in the production of IL-12 p70 and TNF-alpha, increase in the formation of reactive oxygen species and nitric oxide, and elevation of intracellular Ca2+ levels.	Reactive Oxygen Species	172-195	interleukin 1 beta	Mus musculus	69-77
18387518-4	2008	Dendritic cells exposed to lipopolysaccharide, lipoteichoic acid and IL-1beta exhibited increase in the production of IL-12 p70 and TNF-alpha, increase in the formation of reactive oxygen species and nitric oxide, and elevation of intracellular Ca2+ levels.	Nitric Oxide	200-212	interleukin 1 beta	Mus musculus	69-77
18038269-2	2008	In this study, we reported that LPA upregulated interleukin-1 beta (IL-1 beta) expression in mouse J774A.1 macrophages.	lysophosphatidic acid	32-35	interleukin 1 beta	Mus musculus	48-66
18038269-2	2008	In this study, we reported that LPA upregulated interleukin-1 beta (IL-1 beta) expression in mouse J774A.1 macrophages.	lysophosphatidic acid	32-35	interleukin 1 beta	Mus musculus	68-77
18424701-2	2008	As an example, inflammasome-mediated activation of caspase-1 and IL-1beta is crucial for the development of reactive T cells targeting sensitizers like dinitrofluorobenzene (DNFB).	Dinitrofluorobenzene	152-172	interleukin 1 beta	Mus musculus	65-73
18424701-2	2008	As an example, inflammasome-mediated activation of caspase-1 and IL-1beta is crucial for the development of reactive T cells targeting sensitizers like dinitrofluorobenzene (DNFB).	Dinitrofluorobenzene	174-178	interleukin 1 beta	Mus musculus	65-73
18194440-8	2008	Together, these data show that IL-1beta inhibits astrocyte glutamate transport in the spinal cord during viral encephalomyelitis.	Glutamic Acid	59-68	interleukin 1 beta	Mus musculus	31-39
18423275-6	2008	RESULTS: The expression and concentration of IL-1 beta, IL-6, and IL-8 were increased with increasing concentration of 17beta-estradiol.	Estradiol	119-135	interleukin 1 beta	Mus musculus	45-54
18383034-4	2008	DC treated with ROS scavengers, as well as DC from mice that lack a functional NADPH oxidase (and thereby inherently deficient in ROS production) produced significantly increased levels of IL-1beta, IL-6, TNF-alpha and TGF-beta in response to microbial activation.	Reactive Oxygen Species	16-19	interleukin 1 beta	Mus musculus	189-197
18339158-10	2008	In a dose-dependent manner, bupivacaine also significantly inhibited the effects of LPS on the production of TNF-alpha, IL-1beta, and IL-6.	Bupivacaine	28-39	interleukin 1 beta	Mus musculus	120-128
17624531-8	2008	PTX inhibited delayed diarrhea of mice submitted to intestinal mucositis and reduced histopathological damage, intestinal MPO activity, tissue level of TNF-alpha, IL-1beta and KC and TNF-alpha immuno-staining.	Pentoxifylline	0-3	interleukin 1 beta	Mus musculus	163-171
17624531-10	2008	CONCLUSION: These results suggest an important role of TNF-alpha, IL-1beta and KC in the pathogenesis of intestinal mucositis induced by CPT-11.	Irinotecan	137-143	interleukin 1 beta	Mus musculus	66-74
18348728-9	2008	Ten daily doses of ethanol increased brain and liver TNFalpha, and pretreatment with ethanol potentiated LPS-induced increases in TNFalpha, MCP-1, IL-1beta in liver, serum and brain.	Ethanol	85-92	interleukin 1 beta	Mus musculus	147-155
18164693-5	2008	Topical application on mice ears of Tat-SOD also suppressed TPA-induced expression of proinflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 as well as cyclooxygenase-2 (COX-2) and production of PGE(2).	Tetradecanoylphorbol Acetate	60-63	interleukin 1 beta	Mus musculus	131-139
18409051-4	2008	The ginsenosides, Rb1, Rb2, Rc, Rd, Re, Rf and Rg1, significantly attenuated the nociceptive behavior induced by TNF-alpha, IL-1 beta, and IFN-gamma injection, but ginsenoside-Rg3 did not.	Ginsenosides	4-16	interleukin 1 beta	Mus musculus	124-133
18409051-4	2008	The ginsenosides, Rb1, Rb2, Rc, Rd, Re, Rf and Rg1, significantly attenuated the nociceptive behavior induced by TNF-alpha, IL-1 beta, and IFN-gamma injection, but ginsenoside-Rg3 did not.	Ginsenosides	4-15	interleukin 1 beta	Mus musculus	124-133
18310904-0	2008	Effects of cinnamaldehyde on PGE2 release and TRPV4 expression in mouse cerebral microvascular endothelial cells induced by interleukin-1beta.	cinnamaldehyde	11-25	interleukin 1 beta	Mus musculus	124-141
18310904-5	2008	The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production.	Dinoprostone	73-77	interleukin 1 beta	Mus musculus	27-35
18310904-5	2008	The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production.	cinnamaldehyde	82-96	interleukin 1 beta	Mus musculus	27-35
18310904-5	2008	The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production.	cinnamaldehyde	82-96	interleukin 1 beta	Mus musculus	116-124
18310904-5	2008	The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production.	Dinoprostone	133-137	interleukin 1 beta	Mus musculus	27-35
18310904-5	2008	The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production.	Dinoprostone	133-137	interleukin 1 beta	Mus musculus	116-124
18310904-5	2008	The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production.	Dinoprostone	133-137	interleukin 1 beta	Mus musculus	27-35
18310904-5	2008	The results suggested that IL-1beta significantly increase production of PGE2 and cinnamaldehyde evidently decrease IL-1beta-induced PGE2 production, while RR showed no inhibitory effect on PGE2 production.	Dinoprostone	133-137	interleukin 1 beta	Mus musculus	116-124
18310904-7	2008	IL-1beta could up-regulate the expression of TRPV4, RR and cinnamaldehyde could down-regulate the high expression of mRNA and protein of TRPV4 by IL-1beta induced in b.End3 cells.	cinnamaldehyde	59-73	interleukin 1 beta	Mus musculus	0-8
18310904-7	2008	IL-1beta could up-regulate the expression of TRPV4, RR and cinnamaldehyde could down-regulate the high expression of mRNA and protein of TRPV4 by IL-1beta induced in b.End3 cells.	cinnamaldehyde	59-73	interleukin 1 beta	Mus musculus	146-154
18310904-8	2008	In conclusion, cinnamaldehyde decreased the production of PGE2 and the expression of TRPV4 in b.End3 cells induced by IL-1beta.	cinnamaldehyde	15-29	interleukin 1 beta	Mus musculus	118-126
18264118-9	2008	SR140333 and capsaicin significantly inhibited the toxin-induced release of TNF-alpha and IL-1beta.	SR 140333	0-8	interleukin 1 beta	Mus musculus	90-98
18264118-9	2008	SR140333 and capsaicin significantly inhibited the toxin-induced release of TNF-alpha and IL-1beta.	Capsaicin	13-22	interleukin 1 beta	Mus musculus	90-98
18321049-10	2008	Additionally, the LPS-stimulated IL-1beta, IL-6, and TNF-alpha productions are dose-dependently reduced by spilanthol.	N-isobutyl-2E-decenamide	107-117	interleukin 1 beta	Mus musculus	33-41
17624531-7	2008	RESULTS: CPT-11 caused significant diarrhea, histopathological alterations (inflammatory cell infiltration, loss of crypt architecture and villus shortening) and increased intestinal tissue MPO activity, TNF-alpha, IL-1beta and KC level and TNF-alpha immuno-staining.	Irinotecan	9-15	interleukin 1 beta	Mus musculus	215-223
18329889-5	2008	Our results suggest that GM1 administration to female NOD mice beginning at the 4th week of life is able to reduce the index of inflammatory infiltrate and consequently the expression of diabetes, modulating the expression of proinflammatory cytokines (IL-12, IFN-gamma, TNF-alpha and IL-1beta).	G(M1) Ganglioside	25-28	interleukin 1 beta	Mus musculus	285-293
18328448-3	2008	This study investigated the inhibitory mechanism of xanthohumol (XN) against the inflammatory effectors (IL-1beta, TNF-alpha, and iNOS) in activated RAW264.7 macrophages by using different stimuli such as LPS, IFN-gamma, or LPS plus IFN-gamma.	xanthohumol	52-63	interleukin 1 beta	Mus musculus	105-113
18328448-3	2008	This study investigated the inhibitory mechanism of xanthohumol (XN) against the inflammatory effectors (IL-1beta, TNF-alpha, and iNOS) in activated RAW264.7 macrophages by using different stimuli such as LPS, IFN-gamma, or LPS plus IFN-gamma.	xanthohumol	65-67	interleukin 1 beta	Mus musculus	105-113
18174358-7	2008	However, phorbol 12-myristate 13-acetate-induced inflammation was only partially inhibited by GR-TR, which efficiently repressed IL-1beta and MMP-3 genes while weakly repressing IL-6 and TNF-alpha.	Tetradecanoylphorbol Acetate	9-40	interleukin 1 beta	Mus musculus	129-137
18054398-10	2008	Indeed, real time PCR analysis detected a CCI-induced upregulation of Tlr4 and Il1b expression in the lumbar region of wt but not Cckbr KO mice.	CCI	42-45	interleukin 1 beta	Mus musculus	79-83
18279797-4	2008	In addition, asiatic acid dose-dependently reduced the production of IL-6, IL-1 beta and TNF-alpha in LPS-stimulated RAW 264.7 macrophage cells.	asiatic acid	13-25	interleukin 1 beta	Mus musculus	75-84
18279797-7	2008	These results suggest that the anti-inflammatory properties of asiatic acid might be the results from the inhibition of iNOS, COX-2, IL-6, IL-1 beta, and TNF-alpha expressions through the down-regulation of NF-kappaB activation via suppression of IKK and MAP kinase (p38, ERK1/2, and JNK) phosphorylation in RAW 264.7 cells.	asiatic acid	63-75	interleukin 1 beta	Mus musculus	139-148
18279803-7	2008	Fisetin also inhibited the gene expression of TNF-alpha, interleukin (IL)-1 beta, cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS) at both mRNA and protein levels.	fisetin	0-7	interleukin 1 beta	Mus musculus	57-80
18761792-5	2008	Extracellular IL-1 beta increased greatly after exposure to NiSO4 just for 1 h, with the maximum at 48 h (298 pg/ml, P &lt; 0.05), and after exposure to HCA for 6 h, with maximum at 48 h (84 pg/ml, P &lt; 0.05).	nickel sulfate	60-65	interleukin 1 beta	Mus musculus	14-23
18400610-12	2008	MMP-9 and IL-1beta were highly expressed in the acute stage of CAIA.	caia	63-67	interleukin 1 beta	Mus musculus	10-18
18204996-4	2008	Interestingly, IL-1beta, IL-6, and iNOS expression was significantly attenuated by treatment with protein kinase C (PKC) inhibitor (staurosporine) as well as p38 MAP kinase inhibitor (SKF86002) in LPS-stimulated RAW 264.7 cells.	Staurosporine	132-145	interleukin 1 beta	Mus musculus	15-23
18761792-5	2008	Extracellular IL-1 beta increased greatly after exposure to NiSO4 just for 1 h, with the maximum at 48 h (298 pg/ml, P &lt; 0.05), and after exposure to HCA for 6 h, with maximum at 48 h (84 pg/ml, P &lt; 0.05).	hexyl cinnamic aldehyde	153-156	interleukin 1 beta	Mus musculus	14-23
18761792-10	2008	CONCLUSION: Chemical sensitizer DNCB could induce the high expression of CD86 on DC membrane, and NiSO4 and HCA could induce DC to release IL-1 beta and IL-6.	nickel sulfate	98-103	interleukin 1 beta	Mus musculus	139-148
18761792-10	2008	CONCLUSION: Chemical sensitizer DNCB could induce the high expression of CD86 on DC membrane, and NiSO4 and HCA could induce DC to release IL-1 beta and IL-6.	hexyl cinnamic aldehyde	108-111	interleukin 1 beta	Mus musculus	139-148
18250323-9	2008	Importantly, we showed that mBSA induced hypernociception via the IL-33 --&gt; TNFalpha --&gt; IL-1beta --&gt; IFNgamma --&gt; ET-1 --&gt; PGE(2) signaling cascade.	Prostaglandins E	139-142	interleukin 1 beta	Mus musculus	95-103
18294378-10	2008	Mice treated chronically treated with morphine prior to incision were found to have enhanced skin levels of IL-1beta, IL-6, G-CSF, KC and TNFalpha after incision at one or more time points compared to saline pretreated controls.	Morphine	38-46	interleukin 1 beta	Mus musculus	108-116
18060707-4	2008	Our data indicated that SDEE inhibits LPS-stimulated NO, PGE2, IL-1 beta and TNF-alpha release, and iNOS and COX-2 expression.	sdee	24-28	interleukin 1 beta	Mus musculus	63-72
18250441-2	2008	In this study, we demonstrate that proinflammatory cytokines, IL-18 and IL-1beta, reciprocally regulate kainate-induced cerebellar ataxia in mice.	Kainic Acid	104-111	interleukin 1 beta	Mus musculus	72-80
18250441-3	2008	We show that systemic administration of kainate activated IL-1beta and IL-18 predominantly in the cerebellum of mice, which was accompanied with ataxia.	Kainic Acid	40-47	interleukin 1 beta	Mus musculus	58-66
18250441-6	2008	Our data firstly show that IL-18 and IL-1beta display differential direct regulation in kainate-induced ataxia in mice.	Kainic Acid	88-95	interleukin 1 beta	Mus musculus	37-45
17984289-2	2008	In this study, we have explored the role of IL-18, a cytokine with structural similarities to IL-1 beta, in murine LC migration and contact hypersensitivity (CHS), which to oxazolone (OX) and 2-4,dinitrofluorobenzene (DNFB) was suppressed significantly in IL-18 knockout (IL-18-/-) mice and could be rescued by local intradermal administration of IL-18 prior to sensitization, suggesting that the defect in these mice was in the afferent phase of CHS.	Oxazolone	173-182	interleukin 1 beta	Mus musculus	94-103
18298378-5	2008	Amentoflavone showed inhibitory effect on the production of various endogenous factors such as IL-1beta, IL-6, TNF-alpha, GM-CSF, and VEGF that control the process of angiogenesis.	amentoflavone	0-13	interleukin 1 beta	Mus musculus	95-103
18252949-11	2008	Collectively, these data support a model in which the mechanism of inflammation induced decreases in ghrelin are due to the action of IL-1beta on cells within the gastric mucosa that in turn produce prostacyclin as a second messenger.	Epoprostenol	199-211	interleukin 1 beta	Mus musculus	134-142
18686102-5	2008	Amentoflavone treatment markedly decreased the mRNA expression of MMP-2, MMP-9, prolyl hydroxylase, lysyl oxidase, VEGF, ERK-1, ERK-2, TNF-alpha, IL-1beta, IL-6, and GM-CSF in lung tissues.	amentoflavone	0-13	interleukin 1 beta	Mus musculus	146-154
18177902-4	2008	In the mouse air pouch model, administration of avarol produced a dose-dependent reduction of TNF-alpha generation (ED(50) 9.2 nmol/pouch) as well as of interleukin (IL)-1beta, prostaglandin E(2) (PGE(2)) and leukotriene B(4) (LTB(4)) levels in pouch exudates.	avarol	48-54	interleukin 1 beta	Mus musculus	153-175
18177902-5	2008	In the psoriasis-like model of 12-O-tetradecanoylphorbol-acetate-induced mouse epidermal hyperplasia, topical administration of avarol (0.6-1.2 micromol/site) reduced edema, myeloperoxidase activity, IL-1beta, IL-2 and eicosanoid levels in skin.	avarol	128-134	interleukin 1 beta	Mus musculus	200-208
19704783-8	2008	Like other CB(2) ligands also beta-caryophyllene inhibits the pathways triggered by activation of the toll-like receptor complex CD14/TLR4/MD2, which typically lead to the expression of proinflammatory cytokines (IL-1beta, IL-6; IL-8 and TNFalpha) and promotes a TH(1) immune response.	caryophyllene	30-48	interleukin 1 beta	Mus musculus	213-221
18253705-12	2008	Some of the beneficial changes by n-3 FA include enhancing antioxidant enzymes and lowering Th-1/Th-2 cytokines, adhesion molecules, COX-2/PGE(2) levels, pro-inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha etc.	n-3 fa	34-40	interleukin 1 beta	Mus musculus	182-190
17981803-6	2008	The effect of atorvastatin on the LPS-induced increases in IFNgamma and IL-1beta was absent in tissue prepared from IL-4(-/-) mice.	Atorvastatin	14-26	interleukin 1 beta	Mus musculus	72-80
17996413-2	2008	Here, we report that AR displays anti-inflammatory effects in zymosan air-pouch mice by reducing the expression of iNOS, COX-2, IL-6, IL-1beta and TNF-alpha and by decreasing the production of nitric oxide (NO).	Argon	21-23	interleukin 1 beta	Mus musculus	134-142
17868967-2	2008	Although Cinnamaldehyde has been reported to have contact sensitizing properties at high concentration (mM), we found that low concentration of Cinnamaldehyde (muM) inhibited the secretion of interleukin-1beta and tumor necrosis factor alpha within lipopolysaccharide (LPS) or lipoteichoic acid (LTA) stimulated murine J774A.1 macrophages.	cinnamaldehyde	9-23	interleukin 1 beta	Mus musculus	192-241
17868967-2	2008	Although Cinnamaldehyde has been reported to have contact sensitizing properties at high concentration (mM), we found that low concentration of Cinnamaldehyde (muM) inhibited the secretion of interleukin-1beta and tumor necrosis factor alpha within lipopolysaccharide (LPS) or lipoteichoic acid (LTA) stimulated murine J774A.1 macrophages.	cinnamaldehyde	144-158	interleukin 1 beta	Mus musculus	192-241
17868967-2	2008	Although Cinnamaldehyde has been reported to have contact sensitizing properties at high concentration (mM), we found that low concentration of Cinnamaldehyde (muM) inhibited the secretion of interleukin-1beta and tumor necrosis factor alpha within lipopolysaccharide (LPS) or lipoteichoic acid (LTA) stimulated murine J774A.1 macrophages.	mum	160-163	interleukin 1 beta	Mus musculus	192-241
17868967-2	2008	Although Cinnamaldehyde has been reported to have contact sensitizing properties at high concentration (mM), we found that low concentration of Cinnamaldehyde (muM) inhibited the secretion of interleukin-1beta and tumor necrosis factor alpha within lipopolysaccharide (LPS) or lipoteichoic acid (LTA) stimulated murine J774A.1 macrophages.	lipoteichoic acid	277-294	interleukin 1 beta	Mus musculus	192-241
17868967-2	2008	Although Cinnamaldehyde has been reported to have contact sensitizing properties at high concentration (mM), we found that low concentration of Cinnamaldehyde (muM) inhibited the secretion of interleukin-1beta and tumor necrosis factor alpha within lipopolysaccharide (LPS) or lipoteichoic acid (LTA) stimulated murine J774A.1 macrophages.	lipoteichoic acid	296-299	interleukin 1 beta	Mus musculus	192-241
18618311-4	2008	Mice treated with LPS alone showed markedly increased plasma levels of TNF, IL-1beta, IL-6, and IL-10, while mice pretreated with rifampicin showed significantly lower plasma levels of these cytokines compared to the LPS alone.	Rifampin	130-140	interleukin 1 beta	Mus musculus	76-84
18231633-2	2008	We previously reported that 15d-PGJ(2) can suppress interleukin (IL)-1beta-induced prostaglandin E(2) (PGE(2)) synthesis in synoviocytes of rheumatoid arthritis (RA).	15d-pgj	28-35	interleukin 1 beta	Mus musculus	52-74
18571461-8	2008	Furthermore, caffeic acid phenethyl ester rescued C57BL/6 mice from lethal lipopolysaccharide-induced septic shock, while decreasing serum levels of tumor necrosis factor-alpha and interleukin-1beta.	caffeic acid phenethyl ester	13-41	interleukin 1 beta	Mus musculus	181-198
18231633-2	2008	We previously reported that 15d-PGJ(2) can suppress interleukin (IL)-1beta-induced prostaglandin E(2) (PGE(2)) synthesis in synoviocytes of rheumatoid arthritis (RA).	Prostaglandins E	83-99	interleukin 1 beta	Mus musculus	52-74
18231633-2	2008	We previously reported that 15d-PGJ(2) can suppress interleukin (IL)-1beta-induced prostaglandin E(2) (PGE(2)) synthesis in synoviocytes of rheumatoid arthritis (RA).	Prostaglandins E	103-106	interleukin 1 beta	Mus musculus	52-74
18667841-5	2008	Furthermore, IL-1beta-induced p38 mitogen-activated protein kinase (MAPK) activation and upregulation of VEGF-C mRNA and protein in LLC cells was also suppressed by artemisinin or by the p38 MAPK inhibitor SB-203580, suggesting that p38 MAPK could serve as a mediator of proinflammatory cytokine-induced VEGF-C expression.	artemisinin	165-176	interleukin 1 beta	Mus musculus	13-21
18270467-2	2008	All-trans alloxanthin, all-trans diatoxanthin, and their 9-cis isomers isolated from H. roretzi significantly suppressed expression of IL-1beta and IL-6 mRNA in cells induced by LPS without cytotoxicity.	alloxanthin	0-21	interleukin 1 beta	Mus musculus	135-143
18270467-2	2008	All-trans alloxanthin, all-trans diatoxanthin, and their 9-cis isomers isolated from H. roretzi significantly suppressed expression of IL-1beta and IL-6 mRNA in cells induced by LPS without cytotoxicity.	diatoxanthin	23-45	interleukin 1 beta	Mus musculus	135-143
18270467-3	2008	The expression level of IL-1beta mRNA in cells treated with 25 microM all-trans alloxanthin for 24 h, followed by stimulation with 0.1 microg/mL LPS for 24 h in the presence of carotenoid decreased to 33.7+/-3.0% from that of control cells stimulated with LPS alone.	alloxanthin	80-91	interleukin 1 beta	Mus musculus	24-32
18270467-3	2008	The expression level of IL-1beta mRNA in cells treated with 25 microM all-trans alloxanthin for 24 h, followed by stimulation with 0.1 microg/mL LPS for 24 h in the presence of carotenoid decreased to 33.7+/-3.0% from that of control cells stimulated with LPS alone.	Carotenoids	177-187	interleukin 1 beta	Mus musculus	24-32
18270467-4	2008	All-trans diatoxanthin, 9-cis alloxanthin and 9-cis diatoxanthin also decreased expression of IL-1beta mRNA to 25.1+/-2.1, 28.2+/-0.9 and 32.9+/-3.3%, respectively, from that of control cells stimulated with LPS.	diatoxanthin	0-22	interleukin 1 beta	Mus musculus	94-102
18270467-4	2008	All-trans diatoxanthin, 9-cis alloxanthin and 9-cis diatoxanthin also decreased expression of IL-1beta mRNA to 25.1+/-2.1, 28.2+/-0.9 and 32.9+/-3.3%, respectively, from that of control cells stimulated with LPS.	9-cis-Alloxanthin	24-41	interleukin 1 beta	Mus musculus	94-102
18270467-4	2008	All-trans diatoxanthin, 9-cis alloxanthin and 9-cis diatoxanthin also decreased expression of IL-1beta mRNA to 25.1+/-2.1, 28.2+/-0.9 and 32.9+/-3.3%, respectively, from that of control cells stimulated with LPS.	9-cis-Diatoxanthin	46-64	interleukin 1 beta	Mus musculus	94-102
18270467-5	2008	IL-1beta production in culture medium was also suppressed by all-trans alloxanthin and all-trans diatoxanthin.	alloxanthin	61-82	interleukin 1 beta	Mus musculus	0-8
18270467-5	2008	IL-1beta production in culture medium was also suppressed by all-trans alloxanthin and all-trans diatoxanthin.	diatoxanthin	87-109	interleukin 1 beta	Mus musculus	0-8
17629561-10	2008	Acceleration of IL-6 and MMP-3 productions and attenuation of caspase-3/7 activity in IL-1beta-stimulated SC were abated by edaravone.	Edaravone	124-133	interleukin 1 beta	Mus musculus	86-94
17629561-11	2008	Activated NF-kappaB in IL-1beta-stimulated SC was suppressed by edaravone.	Edaravone	64-73	interleukin 1 beta	Mus musculus	23-31
19066129-3	2008	Amentoflavone at a concentration of 10 microg/mL could significantly (p &lt; 0.001) inhibit NO and proinflammatory cytokine (IL-1beta, IL-6, GM-CSF and TNF-alpha) production in B16F-10 cells, TAMs and peritoneal macrophages.	amentoflavone	0-13	interleukin 1 beta	Mus musculus	125-133
18849645-9	2008	RESULTS: Curcumin dose-dependently inhibited TNF-alpha and IL-1beta gene expression and protein synthesis in RAW264.7 cells stimulated with P. gingivalis LPS.	Curcumin	9-17	interleukin 1 beta	Mus musculus	59-67
18667841-5	2008	Furthermore, IL-1beta-induced p38 mitogen-activated protein kinase (MAPK) activation and upregulation of VEGF-C mRNA and protein in LLC cells was also suppressed by artemisinin or by the p38 MAPK inhibitor SB-203580, suggesting that p38 MAPK could serve as a mediator of proinflammatory cytokine-induced VEGF-C expression.	SB 203580	206-215	interleukin 1 beta	Mus musculus	13-21
17924976-3	2007	When macrophages were depleted using clodronate liposomes, both neovascularization and tumor growth were reduced in the IL-1beta-expressing tumors.	Clodronic Acid	37-47	interleukin 1 beta	Mus musculus	120-128
18160842-3	2007	We report here that the LPS-elicited excessive production of NO, TNF-alpha, and IL-1beta in BV-2 cells was largely inhibited in the presence of celastrol, and the attenuation of inducible iNOS and these cytokines resulted from the reduced expression of mRNAs of iNOS and these cytokines, respectively.	celastrol	144-153	interleukin 1 beta	Mus musculus	80-88
18052238-5	2007	Results showed that all of the isoflavone powders and genistein standard were effective in inhibiting LPS-induced inflammation, lowering leukocyte number in mice blood and reducing production of IL-1beta, IL-6, NO, and PGE2 in both peritoneal exudate cell supernatant and peritoneal exudate fluid.	Isoflavones	31-41	interleukin 1 beta	Mus musculus	195-203
18052238-5	2007	Results showed that all of the isoflavone powders and genistein standard were effective in inhibiting LPS-induced inflammation, lowering leukocyte number in mice blood and reducing production of IL-1beta, IL-6, NO, and PGE2 in both peritoneal exudate cell supernatant and peritoneal exudate fluid.	Genistein	54-63	interleukin 1 beta	Mus musculus	195-203
17920531-7	2007	SAA concentrations after silver nitrate injection peaked at 24 h, preceded by increases in serum IL-1 beta and IL-6, associated with decreases in blood leukocytes and local tissue inflammation.	Silver Nitrate	25-39	interleukin 1 beta	Mus musculus	97-106
17931811-3	2007	In lipopolysaccharide (LPS) stimulated RAW264.7 cells, HMCO5 inhibited NF-kappaB activation as well as iNOS promoter activity, inhibited the secretion of TNF-alpha and IL-1beta, and directly inhibited the intracellular accumulation of reactive oxygen species.	hmco5	55-60	interleukin 1 beta	Mus musculus	168-176
18004768-10	2008	Since dexamethasone, a known NF-kappaB inhibitor, could reduce the IL-1 beta-induced NF-kappaB-dependent luminescence in the prostate, NF-kappaB-Luc mice might be useful tool to screen potential candidate drugs for treatment of inflammation and tumor associated with aberrant NF-kappaB activity.	Dexamethasone	6-19	interleukin 1 beta	Mus musculus	67-76
18197910-6	2008	RESULTS: Levels of TNF-alpha, IL-1beta and MIP-2 in the BAL of the ciprofloxacin group were significantly lower compared with those of controls (all P &lt; 0.0083) at 3 and 6 h after LPS challenge.	Ciprofloxacin	67-80	interleukin 1 beta	Mus musculus	30-38
17992263-7	2007	Finally, we found that lung IL-1beta production and inflammation in response to bleomycin required ASC, an inflammasome adaptor molecule.	Bleomycin	80-89	interleukin 1 beta	Mus musculus	28-36
17668318-4	2007	Pharmacological inhibitor of tyrosine kinase, PI3 kinase, protein kinase C, p42/44, p38, JNK and intracellular calcium immobilizing agent down regulated the WGA induced expression of cytokines TNF-alpha, IL-1beta, IL-12 and IFN-gamma.	Calcium	111-118	interleukin 1 beta	Mus musculus	204-212
17668318-9	2007	The pharmacological inhibitors were also used to check the cascade of activation of tyrosine kinase, PKC, PI3 kinase, p42/44, p38, JNK and release of calcium from intracellular storage to sort out the signal pathways involved in the release of TNF-alpha, IL-1beta, IL-12, and IFN-gamma by macrophages on treatment with WGA in vitro.	Calcium	150-157	interleukin 1 beta	Mus musculus	255-263
18096486-6	2007	RESULTS: NAC administered prior to hilar clamping led to a significant decrease in macrophages and lymphocytes and interleukin (IL)-1 beta levels after ischemia.	Acetylcysteine	9-12	interleukin 1 beta	Mus musculus	115-138
17869372-9	2007	PCNA staining and analysis of cell cycle-related proteins also revealed that passive immunization with anti-IL-1beta-neutralizing antibody improved the impaired hepatocellular regeneration and resulted in an improved survival rate of mice treated with G-CSF and DMN.	Dimethylnitrosamine	262-265	interleukin 1 beta	Mus musculus	108-116
17869372-10	2007	CONCLUSIONS: G-CSF administration suppressed liver cell proliferation through the up-regulation of IL-1beta expression in DMN-induced liver injury.	Dimethylnitrosamine	122-125	interleukin 1 beta	Mus musculus	99-107
18096486-7	2007	NAC also resulted in significantly fewer macrophages, lymphocytes and neutrophils as well as IL-1 beta, keratinocyte cytokine (KC), monocyte chemoattractant protein (MCP)-1 and IL-6 levels in BAL taken after reperfusion.	Acetylcysteine	0-3	interleukin 1 beta	Mus musculus	93-102
17581617-10	2007	Microarray and TaqMan real-time PCR showed a downregulation of matrix metalloproteinase 13 and IL-1beta, indicating an effect of doxycycline on transcription.	Doxycycline	129-140	interleukin 1 beta	Mus musculus	95-103
17881510-5	2007	In BMCMCs incubated with the potently cytokinergic SPE-7 IgE without specific antigen, IL-33, IL-1beta, and IL-18 each promoted IL-13 and IL-6 production, but the effects of IL-33 were more potent than those of IL-1beta or IL-18.	bmcmcs	3-9	interleukin 1 beta	Mus musculus	94-102
18006654-6	2007	Macrophages from STZ-treated Ucp2-KO mice had increased IL-1beta and nitric oxide (NO) production, compared with WT macrophages.	Streptozocin	17-20	interleukin 1 beta	Mus musculus	56-64
17855475-9	2007	GLNVA also reduced cyclooxygenase (COX)-2 expression, inhibitor of nuclear factor (NF)-kappaB (IkappaB)alpha/IkappaBbeta degradation, NF-kappaB activation, and the overproduction of tumor necrosis factor-alpha, interleukin (IL)-1beta, and prostaglandin E2 in BV-2 cells.	N-(4-O-glycerol-3-methoxybenzyl)nonivamide	0-5	interleukin 1 beta	Mus musculus	211-233
18062884-9	2007	RESULTS: After the total RNA isolated from the starch stimulated BALB/c mouse PBMC, 843 bp IL-1beta gene in length was prepared by RT-PCR.	Starch	47-53	interleukin 1 beta	Mus musculus	91-99
18062884-13	2007	In a 4-hour based MTT assay, IL-1beta in H22 cells was more resistant to NK92 cell mediated cytotoxicity compared with the cells transfected with pIRES2-EGFP.	monooxyethylene trimethylolpropane tristearate	18-21	interleukin 1 beta	Mus musculus	29-37
17963953-1	2007	Many of the proinflammatory effects of interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha) are mediated through cyclooxygenase-2 (COX-2)-dependent prostaglandin E2 (PGE2).	Dinoprostone	162-178	interleukin 1 beta	Mus musculus	39-61
17669394-12	2007	On the other hand, in LPS-primed mice, the B(1) kinin receptor mediates hypernociception by a mechanism dependent on TNF-alpha and IL-1beta, which could stimulate prostanoid and sympathetic amine production.	Prostaglandins	163-173	interleukin 1 beta	Mus musculus	131-139
17669394-12	2007	On the other hand, in LPS-primed mice, the B(1) kinin receptor mediates hypernociception by a mechanism dependent on TNF-alpha and IL-1beta, which could stimulate prostanoid and sympathetic amine production.	Amines	190-195	interleukin 1 beta	Mus musculus	131-139
17637490-10	2007	The cytokine production, including IL-6, TNF-alpha, and IL-1beta in dioscorin-treated RAW264.7 cells or human monocytes, was measured in the cultured medium.	dioscorin	68-77	interleukin 1 beta	Mus musculus	56-64
17637490-11	2007	Dioscorin (5-100 microg/ml) was found able to induce IL-6, TNF-alpha, and IL-1beta production in RAW264.7 cells and human monocytes.	dioscorin	0-9	interleukin 1 beta	Mus musculus	74-82
17963953-1	2007	Many of the proinflammatory effects of interleukin (IL)-1beta and tumor necrosis factor-alpha (TNF-alpha) are mediated through cyclooxygenase-2 (COX-2)-dependent prostaglandin E2 (PGE2).	Dinoprostone	180-184	interleukin 1 beta	Mus musculus	39-61
18075203-6	2007	In the TNCB-treated sites, marked upregulation of IFN-gamma, IL-1beta, IL-4, and IL-6 mRNA was observed in addition to B2 receptor mRNA.	Picryl Chloride	7-11	interleukin 1 beta	Mus musculus	61-69
17673199-9	2007	Methamphetamine (45 mg/kg) significantly increased mRNA of interleukin-1beta, which is the major endogenous pyrogen, in the hypothalamus of wild-type mice but not in DAT/SERT double KO mice, which provides a partial mechanism of methamphetamine-induced paradoxical hypothermia.	Methamphetamine	0-15	interleukin 1 beta	Mus musculus	59-76
18040640-13	2007	Production of IL-1beta, IL-6, and TNF-alpha in the supernatant was also suppressed by EHDP.	Etidronic Acid	86-90	interleukin 1 beta	Mus musculus	14-22
17577133-7	2007	Expression of inflammatory genes, including endothelial adhesion molecules, but also IL-1beta and TNF-alpha, was significantly reduced in bilirubin-treated animals.	Bilirubin	138-147	interleukin 1 beta	Mus musculus	85-93
17761344-3	2007	It was observed that genestein, wortmannin, H-7, TMB-8, PD98059, SB202190, and tyrophostin (AG490) down regulated the expression of IL-1beta.	Wortmannin	32-42	interleukin 1 beta	Mus musculus	132-140
17761344-3	2007	It was observed that genestein, wortmannin, H-7, TMB-8, PD98059, SB202190, and tyrophostin (AG490) down regulated the expression of IL-1beta.	tyrophostin	79-90	interleukin 1 beta	Mus musculus	132-140
17706870-7	2007	Morphine increased osteoclast activity and upregulated IL-1 beta within the femurs of sarcoma-treated mice suggesting enhancement of sarcoma-induced osteolysis.	Morphine	0-8	interleukin 1 beta	Mus musculus	55-64
17673199-9	2007	Methamphetamine (45 mg/kg) significantly increased mRNA of interleukin-1beta, which is the major endogenous pyrogen, in the hypothalamus of wild-type mice but not in DAT/SERT double KO mice, which provides a partial mechanism of methamphetamine-induced paradoxical hypothermia.	Methamphetamine	229-244	interleukin 1 beta	Mus musculus	59-76
17690174-8	2007	CIH caused significant increases in lipid peroxidation in serum and liver tissue; significant increases in hepatic levels of myeloperoxidase and proinflammatory cytokines IL-1beta, IL-6, and CXC chemokine MIP-2; a trend toward an increase in TNF-alpha; and an increase in alpha1(I)-collagen mRNA.	cih	0-3	interleukin 1 beta	Mus musculus	171-179
17950363-9	2007	The production of the proinflammatory cytokines TNF-alpha and IL-1 beta by peritoneal macrophages from lipopolysaccharide (LPS)-treated GVHD mice was significantly inhibited by roquinimex treatment.	roquinimex	177-187	interleukin 1 beta	Mus musculus	62-71
17898286-8	2007	rmST2- versus PBS-injected mice exhibited increased bacterial load, PMN infiltrate, and higher corneal mRNA levels for IL-1beta, MIP-2, IL-6, IL-1R1, and Th1-type cytokine such as IFN-gamma.	Lead	14-17	interleukin 1 beta	Mus musculus	119-127
17490854-8	2007	Interestingly, the basal concentration of IL-1beta in the corpus callosum of CPZ treated animals was significantly increased, which was in keeping with the increase in activated microglial cells.	Cuprizone	77-80	interleukin 1 beta	Mus musculus	42-50
17632100-3	2007	Intravenous administration of TAK-242 to mice 1 h before LPS challenge dose-dependently inhibited LPS-induced increases in serum levels of TNF-alpha, IL-1beta, IL-6, IL-10, MIP-2, and NO metabolites.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	30-37	interleukin 1 beta	Mus musculus	150-158
18156782-5	2007	It was observed that GABA significantly inhibited the mRNA expression of iNOS, IL-1beta, and TNF-alpha, in LPS-stimulated RAW 264.7 cells.	gamma-Aminobutyric Acid	21-25	interleukin 1 beta	Mus musculus	79-87
17548806-6	2007	Moreover, ST2825 interfered with recruitment of IRAK1 and IRAK4 by MyD88, causing inhibition of IL-1beta-mediated activation of NF-kappaB transcriptional activity.	ST2825	10-16	interleukin 1 beta	Mus musculus	96-104
17548806-7	2007	After oral administration, ST2825 dose-dependently inhibited IL-1beta-induced production of IL-6 in treated mice.	ST2825	27-33	interleukin 1 beta	Mus musculus	61-69
17852747-2	2007	We investigated the effects of 5,7-dimethoxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin not only on the formation of nitric oxide (NO), PGE(2), TNF-alpha, IL-6 and IL-1beta, but also on inducible NO synthase and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells.	5,7,4'-Trimethoxy-4-phenylcoumarin	31-71	interleukin 1 beta	Mus musculus	183-191
17965763-6	2007	MCE also reduced the concentration of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in the Raw264.7 cells that were activated by LPS.	lps	178-181	interleukin 1 beta	Mus musculus	79-96
17881516-4	2007	This IL-1beta-mediated potentiation of hypoxic neuronal injury was associated with an increase in both cellular cystine uptake ([cystine]i) and extracellular glutamate levels ([glutamate]e) and was prevented by either ionotropic glutamate receptor antagonism or removal of L-cystine, suggesting a role for the cystine/glutamate antiporter (System x(c)-).	Cystine	112-119	interleukin 1 beta	Mus musculus	5-13
17881516-4	2007	This IL-1beta-mediated potentiation of hypoxic neuronal injury was associated with an increase in both cellular cystine uptake ([cystine]i) and extracellular glutamate levels ([glutamate]e) and was prevented by either ionotropic glutamate receptor antagonism or removal of L-cystine, suggesting a role for the cystine/glutamate antiporter (System x(c)-).	Cystine	129-136	interleukin 1 beta	Mus musculus	5-13
17881516-4	2007	This IL-1beta-mediated potentiation of hypoxic neuronal injury was associated with an increase in both cellular cystine uptake ([cystine]i) and extracellular glutamate levels ([glutamate]e) and was prevented by either ionotropic glutamate receptor antagonism or removal of L-cystine, suggesting a role for the cystine/glutamate antiporter (System x(c)-).	Glutamic Acid	158-167	interleukin 1 beta	Mus musculus	5-13
17881516-4	2007	This IL-1beta-mediated potentiation of hypoxic neuronal injury was associated with an increase in both cellular cystine uptake ([cystine]i) and extracellular glutamate levels ([glutamate]e) and was prevented by either ionotropic glutamate receptor antagonism or removal of L-cystine, suggesting a role for the cystine/glutamate antiporter (System x(c)-).	Glutamic Acid	177-186	interleukin 1 beta	Mus musculus	5-13
17881516-4	2007	This IL-1beta-mediated potentiation of hypoxic neuronal injury was associated with an increase in both cellular cystine uptake ([cystine]i) and extracellular glutamate levels ([glutamate]e) and was prevented by either ionotropic glutamate receptor antagonism or removal of L-cystine, suggesting a role for the cystine/glutamate antiporter (System x(c)-).	Cystine	273-282	interleukin 1 beta	Mus musculus	5-13
17881516-4	2007	This IL-1beta-mediated potentiation of hypoxic neuronal injury was associated with an increase in both cellular cystine uptake ([cystine]i) and extracellular glutamate levels ([glutamate]e) and was prevented by either ionotropic glutamate receptor antagonism or removal of L-cystine, suggesting a role for the cystine/glutamate antiporter (System x(c)-).	Cystine	129-136	interleukin 1 beta	Mus musculus	5-13
17881516-4	2007	This IL-1beta-mediated potentiation of hypoxic neuronal injury was associated with an increase in both cellular cystine uptake ([cystine]i) and extracellular glutamate levels ([glutamate]e) and was prevented by either ionotropic glutamate receptor antagonism or removal of L-cystine, suggesting a role for the cystine/glutamate antiporter (System x(c)-).	Glutamic Acid	177-186	interleukin 1 beta	Mus musculus	5-13
17881516-7	2007	Finally, assessment of System x(c)- function and kinetics in IL-1beta-treated cultures revealed an increase in velocity of cystine transport (Vmax), in the absence of a change in affinity (Km).	Cystine	123-130	interleukin 1 beta	Mus musculus	61-69
17678631-2	2007	Here, we demonstrated the role of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and mitogen-activated protein kinases (MAPKs) on the antinociceptive action of myricitrin.	myricitrin	183-193	interleukin 1 beta	Mus musculus	34-51
17678631-2	2007	Here, we demonstrated the role of interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and mitogen-activated protein kinases (MAPKs) on the antinociceptive action of myricitrin.	myricitrin	183-193	interleukin 1 beta	Mus musculus	53-61
17678631-9	2007	The calculated ID(50) of myricitrin were 6.8 (4.6-9.0) and 2.6 (0.3-4.9) mg/kg and maximal inhibition of 83+/-9 and 100+/-0% for IL-1beta and TNF-alpha, respectively.	myricitrin	25-35	interleukin 1 beta	Mus musculus	129-137
17678631-10	2007	Intrathecal injection of IL-1beta and TNF-alpha significantly increased p38(MAPK) phosphorylation and this was inhibited by myricitrin treatment.	myricitrin	124-134	interleukin 1 beta	Mus musculus	25-33
17678632-4	2007	Moreover, TMMC suppressed the expression of intercellular adhesion molecule-1, interleukin 1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the mice treated with TNBS.	2',4',6'-tris(methoxymethoxy) chalcone	10-14	interleukin 1 beta	Mus musculus	79-96
17678632-4	2007	Moreover, TMMC suppressed the expression of intercellular adhesion molecule-1, interleukin 1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the mice treated with TNBS.	2',4',6'-tris(methoxymethoxy) chalcone	10-14	interleukin 1 beta	Mus musculus	98-106
17678632-4	2007	Moreover, TMMC suppressed the expression of intercellular adhesion molecule-1, interleukin 1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the mice treated with TNBS.	Trinitrobenzenesulfonic Acid	177-181	interleukin 1 beta	Mus musculus	79-96
17678632-4	2007	Moreover, TMMC suppressed the expression of intercellular adhesion molecule-1, interleukin 1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the mice treated with TNBS.	Trinitrobenzenesulfonic Acid	177-181	interleukin 1 beta	Mus musculus	98-106
17670890-6	2007	An acute application of 10 ng/ml IL-1beta induced Ca(2+) mobilization from intracellular stores and activated store-operated Ca(2+) entry (SOCE) and receptor-operated Ca(2+) entry (ROCE) in both freshly dissociated and cultured actrocytes.	roce	181-185	interleukin 1 beta	Mus musculus	33-41
17670890-10	2007	In the presence of extracellular Ba(2+), OAG-induced elevations of cytosolic Ba(2+) (fura-2 340-to-380-nm ratio) were significantly larger in astrocytes treated with IL-1beta.	Barium	33-35	interleukin 1 beta	Mus musculus	166-174
17670890-10	2007	In the presence of extracellular Ba(2+), OAG-induced elevations of cytosolic Ba(2+) (fura-2 340-to-380-nm ratio) were significantly larger in astrocytes treated with IL-1beta.	1-oleoyl-2-acetylglycerol	41-44	interleukin 1 beta	Mus musculus	166-174
17670890-10	2007	In the presence of extracellular Ba(2+), OAG-induced elevations of cytosolic Ba(2+) (fura-2 340-to-380-nm ratio) were significantly larger in astrocytes treated with IL-1beta.	N-methyl-valyl-amiclenomycin	33-39	interleukin 1 beta	Mus musculus	166-174
17670890-10	2007	In the presence of extracellular Ba(2+), OAG-induced elevations of cytosolic Ba(2+) (fura-2 340-to-380-nm ratio) were significantly larger in astrocytes treated with IL-1beta.	Fura-2	85-91	interleukin 1 beta	Mus musculus	166-174
17675415-3	2007	The crucial role of IL-1beta in inflammation has been highlighted by studies performed in caspase-1 knockout mice (casp1(-/-)), transgenic mice that lack mature IL-1beta and survive lethal doses of lypopolysaccharide (LPS).	lypopolysaccharide	198-216	interleukin 1 beta	Mus musculus	20-28
17675415-5	2007	Moreover, we documented that peripherally injected LPS triggers a specific spatiotemporal pattern of expression of IL-1beta mRNA within the brain, suggesting that IL-1beta could be a major regulator of the central inflammatory cascade.	lps	51-54	interleukin 1 beta	Mus musculus	115-123
17675415-5	2007	Moreover, we documented that peripherally injected LPS triggers a specific spatiotemporal pattern of expression of IL-1beta mRNA within the brain, suggesting that IL-1beta could be a major regulator of the central inflammatory cascade.	lps	51-54	interleukin 1 beta	Mus musculus	163-171
17596528-6	2007	Mice subjected to renal IR under isoflurane anesthesia also showed a reduction in inflammation evidenced by a reduced renal influx of neutrophils and macrophages, reduced ICAM-1 expression, less upregulation of proinflammatory mRNAs (TNF-alpha, ICAM-1, KC, and IL-1beta) as well as reduced nuclear translocation of NF-kappaB 24 h after renal IR injury.	Isoflurane	33-43	interleukin 1 beta	Mus musculus	261-269
17690185-3	2007	Here, we show that dexamethasone inhibits IL-1beta-induced neovascularization and the expression of the angiogenesis-related factors, vascular endothelial growth factor-A, KC, and prostaglandin E(2) in the mouse cornea 2 days after IL-1beta implantation.	Dexamethasone	19-32	interleukin 1 beta	Mus musculus	42-50
17690185-3	2007	Here, we show that dexamethasone inhibits IL-1beta-induced neovascularization and the expression of the angiogenesis-related factors, vascular endothelial growth factor-A, KC, and prostaglandin E(2) in the mouse cornea 2 days after IL-1beta implantation.	Dexamethasone	19-32	interleukin 1 beta	Mus musculus	232-240
17965763-6	2007	MCE also reduced the concentration of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in the Raw264.7 cells that were activated by LPS.	lps	178-181	interleukin 1 beta	Mus musculus	98-106
17889310-7	2007	The LPS-induced expression of IL-1beta, IL-6, MIF, gp130, and receptors IL-1RI, IL-1RII, and IL-6Ralpha were also significantly impaired by EtOH.	Ethanol	140-144	interleukin 1 beta	Mus musculus	30-38
17565047-8	2007	SR140333 injected 30 min before or 1 h after CLP significantly attenuated the increased lung MPO activity and levels of MIP-2, MCP-1, IL-1beta, IL-6, ICAM-1, and E- and P-selectin compared with CLP-operated mice injected with the vehicle.	SR 140333	0-8	interleukin 1 beta	Mus musculus	134-142
17618462-9	2007	The IL-1beta expressions were inhibited by ketotifen in the two strains, but TNF-alpha expression was inhibited in the C3H/HeN mice after ketotifen treatment.	Ketotifen	43-52	interleukin 1 beta	Mus musculus	4-12
17718807-1	2007	In this study, effect of flunixin meglumine on serum tumour necrosis factor alpha, (TNFalpha) interleukin-1 beta and interleukin-10 levels was investigated in lipopolysaccharide-induced endotoxic mice.	flunixin meglumine	25-43	interleukin 1 beta	Mus musculus	94-112
17665394-7	2007	The CoPP-induced expression of HO-1 in the joints and liver was associated with marked decreases in IL-1beta, IL-6, and TNFalpha levels, PGE(2) secretion, and MMP-9 activity in serum, and with a marked increase in systemic antioxidant activity.	cobaltiprotoporphyrin	4-8	interleukin 1 beta	Mus musculus	100-108
17803048-5	2007	To determine whether carbamoylcholine chloride increased Th1 cytokine (IL2, IL12[p70], and interferon gamma), Th2 cytokine (IL4, IL5, and IL10), granulocyte-macrophage colony-stimulating factor (GM-CSF), or proinflammatory cytokine (IL1beta, tumor necrosis factor alpha, and IL6 in saliva and serum) levels, mice were given 10 microg carbamoylcholine chloride and euthanized.	Carbachol	21-46	interleukin 1 beta	Mus musculus	233-240
17592514-0	2007	Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression.	Cannabidiol	0-11	interleukin 1 beta	Mus musculus	81-89
17573052-7	2007	Of note, AGM (10-100 mg/kg, i.p., 30 min before) also elicited a pronounced inhibition of the biting response induced by TNF-alpha and IL-1beta in mice, with mean ID(50) values of 61.3 mg/kg (47.7-78.6 mg/kg) and 30.4 mg/kg (18.6-49.8 mg/kg) and inhibitions of 75+/-5% and 66+/-6%, respectively.	Agmatine	9-12	interleukin 1 beta	Mus musculus	135-143
17687515-8	2007	Moreover, the striatal dopamine-depleted mice demonstrated an increased concentration of IL-1beta and decreased concentration of TGFbeta in the spinal cord, compared to EAE mice.	Dopamine	23-31	interleukin 1 beta	Mus musculus	89-97
17583797-6	2007	Also, in primary islets of reporter gene mice, IL-1beta reduced glucose-stimulated INS transcription.	Glucose	64-71	interleukin 1 beta	Mus musculus	47-55
17417780-9	2007	In addition, the treatment with ONO-1714 significantly lowered the serum triglyceride levels and mRNA expression levels of COX-2, TNFalpha and IL-1beta of colonic mucosa in the DSS-treated Apc(Min/+) mice.	7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane	32-40	interleukin 1 beta	Mus musculus	143-151
17417780-9	2007	In addition, the treatment with ONO-1714 significantly lowered the serum triglyceride levels and mRNA expression levels of COX-2, TNFalpha and IL-1beta of colonic mucosa in the DSS-treated Apc(Min/+) mice.	dss	177-180	interleukin 1 beta	Mus musculus	143-151
17669273-0	2007	Differential effects of anti-IL-1R accessory protein antibodies on IL-1alpha or IL-1beta-induced production of PGE(2) and IL-6 from 3T3-L1 cells.	Prostaglandins E	111-114	interleukin 1 beta	Mus musculus	80-88
17669273-3	2007	An anti-peptide-4 antibody which targets domain III inhibited 70% of IL-1beta-induced productions of IL-6 and PGE(2) from 3T3-L1 cells.	Prostaglandins E	110-113	interleukin 1 beta	Mus musculus	69-77
17601777-8	2007	administration of rsCD6 before lethal LPS challenge significantly improved mice survival, and this was concomitant with reduced serum levels of the proinflammatory cytokines TNF-alpha, IL6, and IL-1beta.	rscd6	18-23	interleukin 1 beta	Mus musculus	194-202
17617617-4	2007	Furthermore, both baseline and dextran sulfate sodium-induced IL-1beta production in the intestine were significantly up-regulated in MMP-7(-/-) mice compared with that in control C57BL/6 mice.	Dextran Sulfate	31-53	interleukin 1 beta	Mus musculus	62-70
17628610-2	2007	We investigated dextran sulfate sodium (DSS)-induced IL-1 beta production and caspase-1 activities in murine peritoneal macrophages (pM phi).	Dextran Sulfate	16-38	interleukin 1 beta	Mus musculus	53-62
17628610-2	2007	We investigated dextran sulfate sodium (DSS)-induced IL-1 beta production and caspase-1 activities in murine peritoneal macrophages (pM phi).	Dextran Sulfate	40-43	interleukin 1 beta	Mus musculus	53-62
17628610-5	2007	DSS-treated pM phi released IL-1 beta protein in a time-dependent manner without affecting mRNA levels during 3-24 h, and caspase-1 activity peaked at 5 min (29-fold).	Dextran Sulfate	0-3	interleukin 1 beta	Mus musculus	28-37
17628610-6	2007	IL-1 beta release and caspase-1 activity induced by DSS were significantly inhibited by a MAPK kinase 1/2 inhibitor, a p38 MAPK inhibitor, and NAC, however, not by JNK1/2 or a protein kinase C inhibitor.	Dextran Sulfate	52-55	interleukin 1 beta	Mus musculus	0-9
17628610-9	2007	Pre-treatment with anti-CXCL16 for 24 h, but not anti-scavenger receptor-A, anti-CD36, or anti-CD68 antibodies, significantly suppressed DSS-induced IL-1 beta production.	Dextran Sulfate	137-140	interleukin 1 beta	Mus musculus	149-158
17628610-10	2007	Our results suggest that DSS triggers the release of IL-1 beta protein from murine pM phi at a post-translational level through binding with CXCL16, ROS generation, and resultant activation of both p38 MAPK and ERK1/2 pathways, and finally caspase-1 activation.	Dextran Sulfate	25-28	interleukin 1 beta	Mus musculus	53-62
17628610-10	2007	Our results suggest that DSS triggers the release of IL-1 beta protein from murine pM phi at a post-translational level through binding with CXCL16, ROS generation, and resultant activation of both p38 MAPK and ERK1/2 pathways, and finally caspase-1 activation.	Reactive Oxygen Species	149-152	interleukin 1 beta	Mus musculus	53-62
17703739-3	2007	Acharan sulfate increased the phagocytic activity, the production of cytokines such as TNF-alpha and IL-1beta, and the release of nitric oxide on a macrophage cell line, Raw 264.7 cells.	acharan sulfate	0-15	interleukin 1 beta	Mus musculus	101-109
17880775-4	2007	An increase in immunoreactivity to nitrotyrosine, iNOS, TNF-alpha and IL-1beta was also observed in the lungs of BLM-treated mice.	Bleomycin	113-116	interleukin 1 beta	Mus musculus	70-78
17499198-3	2007	The methanol extract of PC (PC extract) attenuated LPS-stimulated increase in production of TNF-alpha, IL-1beta, and NO in BV2 cells, a mouse microglia cell line, as well as in primary mouse microglia.	Methanol	4-12	interleukin 1 beta	Mus musculus	103-111
17499198-3	2007	The methanol extract of PC (PC extract) attenuated LPS-stimulated increase in production of TNF-alpha, IL-1beta, and NO in BV2 cells, a mouse microglia cell line, as well as in primary mouse microglia.	pc	24-26	interleukin 1 beta	Mus musculus	103-111
17499198-3	2007	The methanol extract of PC (PC extract) attenuated LPS-stimulated increase in production of TNF-alpha, IL-1beta, and NO in BV2 cells, a mouse microglia cell line, as well as in primary mouse microglia.	pc	28-30	interleukin 1 beta	Mus musculus	103-111
17363730-4	2007	The TLR ligands lipopolysacharride (TLR4), zymosan (TLR2/6), and CpG oligonucleotide (TLR9) caused, in a complement-dependent manner, strikingly elevated plasma interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and IL-1beta, and/or decreased plasma IL-12 levels in mice deficient in the membrane complement inhibitor decay-accelerating factor (DAF).	lipopolysacharride	16-34	interleukin 1 beta	Mus musculus	228-236
17363730-4	2007	The TLR ligands lipopolysacharride (TLR4), zymosan (TLR2/6), and CpG oligonucleotide (TLR9) caused, in a complement-dependent manner, strikingly elevated plasma interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and IL-1beta, and/or decreased plasma IL-12 levels in mice deficient in the membrane complement inhibitor decay-accelerating factor (DAF).	Zymosan	43-50	interleukin 1 beta	Mus musculus	228-236
17363730-4	2007	The TLR ligands lipopolysacharride (TLR4), zymosan (TLR2/6), and CpG oligonucleotide (TLR9) caused, in a complement-dependent manner, strikingly elevated plasma interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and IL-1beta, and/or decreased plasma IL-12 levels in mice deficient in the membrane complement inhibitor decay-accelerating factor (DAF).	Oligonucleotides	69-84	interleukin 1 beta	Mus musculus	228-236
17416798-6	2007	In addition, we show that rosiglitazone inhibits JNK activation and promotes the survival of pancreatic beta-cells exposed to interleukin-1beta.	Rosiglitazone	26-39	interleukin 1 beta	Mus musculus	126-143
17880762-7	2007	The post-treatment with ginsan increased the mRNA expression levels of TNF-alpha, IL-1beta, IL-6, SCF, and GM-CSF with respect to that of the CP alone or ginsan pre-treated group.	ginsan	24-30	interleukin 1 beta	Mus musculus	82-90
17880775-5	2007	In contrast, administration of BLM-treated mice with TDZD-8 (1 mg/kg daily) significantly reduced (I) the degree of lung injury, (II) the increase in staining (immunohistochemistry) for myeloperoxidase (MPO), nitrotyrosine, iNOS, TNF-alpha and IL-1beta and (III) the degree of apoptosis, as evaluated by Bax and Bcl-2 immunoreactivity and TUNEL staining.	Bleomycin	31-34	interleukin 1 beta	Mus musculus	244-252
17880763-4	2007	CSBG exposure induced neutrophilic and eosinophilic inflammation in the lung, which was concomitant with the increased local expression of proinflammatory cytokines including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, macrophage inflammatory protein -1alpha, macrophage chemoattractant protein -1, RANTES (regulated on activation and normal T cells expressed and secreted), and eotaxin.	csbg	0-4	interleukin 1 beta	Mus musculus	204-226
17880775-5	2007	In contrast, administration of BLM-treated mice with TDZD-8 (1 mg/kg daily) significantly reduced (I) the degree of lung injury, (II) the increase in staining (immunohistochemistry) for myeloperoxidase (MPO), nitrotyrosine, iNOS, TNF-alpha and IL-1beta and (III) the degree of apoptosis, as evaluated by Bax and Bcl-2 immunoreactivity and TUNEL staining.	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	53-59	interleukin 1 beta	Mus musculus	244-252
17882968-0	2007	[Structure-activity relationship of phenylallyl compounds inhibiting PGE2 release in mouse cerebral microvascular endothelial cells induced by IL-1beta].	phenylallyl	36-47	interleukin 1 beta	Mus musculus	143-151
17400889-0	2007	Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney.	Cisplatin	0-9	interleukin 1 beta	Mus musculus	86-108
17400889-4	2007	We first examined IL-1beta; renal IL-1beta increased nearly 2-fold in cisplatin-induced ARF and was reduced in the caspase-1(-/-) mice.	Cisplatin	70-79	interleukin 1 beta	Mus musculus	34-42
17400889-9	2007	In summary, our data demonstrated that cisplatin-induced ARF is associated with increases in the cytokines IL-1beta, IL-18, and IL-6 and neutrophil infiltration in the kidney.	Cisplatin	39-48	interleukin 1 beta	Mus musculus	107-115
17473064-11	2007	Furthermore, CpG-oligodeoxynucleotide challenge resulted in a strong release of several inflammatory cytokines, such as TNF-alpha, and IL-1beta, -6, -10, and -12 in vivo as well as in vitro.	Oligodeoxyribonucleotides	17-37	interleukin 1 beta	Mus musculus	135-143
17882968-0	2007	[Structure-activity relationship of phenylallyl compounds inhibiting PGE2 release in mouse cerebral microvascular endothelial cells induced by IL-1beta].	Dinoprostone	69-73	interleukin 1 beta	Mus musculus	143-151
17882968-3	2007	Different concentrations of phenylallyl compounds were added separately, and the content of PGE2 induced by IL-1beta in the culture media was measured by ELISA assay.	Dinoprostone	92-96	interleukin 1 beta	Mus musculus	108-116
17445776-8	2007	Treatment of RAW 264.7 cells with CCL-34 also activated TLR4-downstream mitogen-activated protein kinases (ERK, JNK and p38), induced expression of TLR4-downstream genes (TNF-alpha, IL-6, IL-1beta and iNOS) and promoted production of cytokines characteristic of activated macrophages.	Cefaclor	34-37	interleukin 1 beta	Mus musculus	188-196
17226782-9	2007	However, after treatment with keratinocyte-conditioned medium or cytokine mixtures containing at least TNF-alpha and IL-1beta, they became transiently coupled through a pathway sensitive to octanol, a gap junction blocker.	Octanols	190-197	interleukin 1 beta	Mus musculus	117-125
17535900-2	2007	To determine the mechanism by which IL-1beta depresses respiration, we examined a prostaglandin E(2) (PGE(2))-dependent pathway in newborn mice and human neonates.	Dinoprostone	82-100	interleukin 1 beta	Mus musculus	36-44
17535900-2	2007	To determine the mechanism by which IL-1beta depresses respiration, we examined a prostaglandin E(2) (PGE(2))-dependent pathway in newborn mice and human neonates.	Dinoprostone	102-108	interleukin 1 beta	Mus musculus	36-44
17535900-8	2007	We conclude that IL-1beta adversely affects breathing and its control by mPGES-1 activation and PGE(2) binding to brainstem EP3 receptors, resulting in increased apnea frequency and hypoxia-induced mortality.	Dinoprostone	96-102	interleukin 1 beta	Mus musculus	17-25
17255557-5	2007	IL-1beta up-regulated bradykinin B(1) and B(2) receptor expression and increased contractile response to bradykinin B(1) and B(2) receptor agonists (des-Arg(9)-bradykinin and bradykinin, respectively) in the tracheal smooth muscle.	des-arg	149-156	interleukin 1 beta	Mus musculus	0-8
17291600-8	2007	CGRP(8-37) or combination of SR 140333 and SR 48968 diminished neutrophil accumulation, MPO levels and IL-1beta production, airway hyperresponsiveness was inhibited only by SR 48968.	SR 140333	29-38	interleukin 1 beta	Mus musculus	103-111
17291600-8	2007	CGRP(8-37) or combination of SR 140333 and SR 48968 diminished neutrophil accumulation, MPO levels and IL-1beta production, airway hyperresponsiveness was inhibited only by SR 48968.	SR 48968	43-51	interleukin 1 beta	Mus musculus	103-111
17593005-11	2007	The GSNO treatment of EAU animals significantly attenuated the levels of TNF-alpha, IL-1beta, IFN-gamma, and IL-10 in retinas, as measured by quantitative real-time polymerase chain reaction analysis.	S-Nitrosoglutathione	4-8	interleukin 1 beta	Mus musculus	84-92
17273160-4	2007	Upon a single skin painting with DNFB, C57BL/6 developed within hours a more severe dose-dependent ICD response as compared to BALB/C mice, which was associated with enhanced upregulation of IL-1beta, IL-6, and IL-10.	Dinitrofluorobenzene	33-37	interleukin 1 beta	Mus musculus	191-199
17593005-11	2007	The GSNO treatment of EAU animals significantly attenuated the levels of TNF-alpha, IL-1beta, IFN-gamma, and IL-10 in retinas, as measured by quantitative real-time polymerase chain reaction analysis.	Water	22-25	interleukin 1 beta	Mus musculus	84-92
17320857-7	2007	Additionally, budlein A (10.0 mg/kg) treatment inhibited the mechanical hypernociception-induced by tumour necrosis factor (TNF-alpha, 36%), Keratinocyte-derived chemokine (KC, 37%) and Interleukin-1beta (IL-1beta, 28%), but not of prostaglandin E(2) or dopamine.	budlein A	14-23	interleukin 1 beta	Mus musculus	186-203
17292408-17	2007	DEX administration could significantly reduce the levels of serum TNF-alpha, IL-1beta, IFN-gamma, aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), and nitrite.	Dexamethasone	0-3	interleukin 1 beta	Mus musculus	77-85
17320857-7	2007	Additionally, budlein A (10.0 mg/kg) treatment inhibited the mechanical hypernociception-induced by tumour necrosis factor (TNF-alpha, 36%), Keratinocyte-derived chemokine (KC, 37%) and Interleukin-1beta (IL-1beta, 28%), but not of prostaglandin E(2) or dopamine.	budlein A	14-23	interleukin 1 beta	Mus musculus	205-213
17320857-8	2007	Budlein A also inhibited the carrageenan-induced release of TNF-alpha (52%), KC (70%) and IL-1beta (59%).	budlein A	0-9	interleukin 1 beta	Mus musculus	90-98
17320857-8	2007	Budlein A also inhibited the carrageenan-induced release of TNF-alpha (52%), KC (70%) and IL-1beta (59%).	Carrageenan	29-40	interleukin 1 beta	Mus musculus	90-98
17253612-10	2007	Analysis of cytokine levels in colon homogenates showed a significant decrease of IL-1beta, IL-8, and TNFalpha levels in ciprofloxacin-treated animals.	Ciprofloxacin	121-134	interleukin 1 beta	Mus musculus	82-90
17407556-3	2007	METHODS: The effect of IL-1beta on 5-hydroxytryptamine (5-HT) induced bronchoconstriction was evaluated in an in-vitro model for assessment of long-term effects of inflammatory mediators on the airway smooth muscle.	Serotonin	35-54	interleukin 1 beta	Mus musculus	23-31
17446211-6	2007	It is also observed that pre-treatment of macrophages with cisplatin and subsequent incubation with TLR ligands significantly enhanced the production of pro-inflammatory cytokines (tumor necrosis factor-alpha, IFN-gamma, IL-1beta and IL-12) and iNOS expression in macrophages.	Cisplatin	59-68	interleukin 1 beta	Mus musculus	221-229
17404266-0	2007	Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36.	ursolic acid	11-23	interleukin 1 beta	Mus musculus	57-65
17404266-4	2007	UA increased the protein release of IL-1beta, IL-6, and MIF, but not of TNF-alpha, in dose- and time-dependent manners.	ursolic acid	0-2	interleukin 1 beta	Mus musculus	36-44
17404266-6	2007	The release of UA-induced IL-1beta was significantly inhibited by the inhibitors of p38 MAPK, MEK1/2, ATP-binding cassette transporter, and caspase-1.	ursolic acid	15-17	interleukin 1 beta	Mus musculus	26-34
17404266-7	2007	Furthermore, UA induced intracellular ROS generation for IL-1beta production, which was suppressed by an antioxidant.	ursolic acid	13-15	interleukin 1 beta	Mus musculus	57-65
17404266-7	2007	Furthermore, UA induced intracellular ROS generation for IL-1beta production, which was suppressed by an antioxidant.	ros	38-41	interleukin 1 beta	Mus musculus	57-65
17404266-8	2007	Pretreatment with an anti-CD36 Ab significantly suppressed IL-1beta release, and surface plasmon resonance assay results showed that UA bound to CD36 on macrophages.	ursolic acid	133-135	interleukin 1 beta	Mus musculus	59-67
17404266-9	2007	In addition, the amount of IL-1beta released from UA-treated pMphi of CD36-deficient mice was markedly lower than that from those of wild-type mice.	ursolic acid	50-52	interleukin 1 beta	Mus musculus	27-35
17404266-10	2007	Interestingly, UA was found to aggregate in culture medium, and the aggregates were suggested to be responsible for IL-1beta production.	ursolic acid	15-17	interleukin 1 beta	Mus musculus	116-124
17404266-12	2007	administration of UA increased the levels of IL-1beta secretion and MPO activity in colonic mucosa of ICR mice.	ursolic acid	18-20	interleukin 1 beta	Mus musculus	45-53
17404266-13	2007	Taken together, our results indicate that aggregated UA is recognized, in part, by CD36 on macrophages for generating ROS, thereby activating p38 MAPK, ERK1/2, and caspase-1, as well as releasing IL-1beta protein via the ATP-binding cassette transporter.	ursolic acid	53-55	interleukin 1 beta	Mus musculus	196-204
17300811-0	2007	Biphasic regulation of levofloxacin on lipopolysaccharide-induced IL-1beta production.	Levofloxacin	23-35	interleukin 1 beta	Mus musculus	66-74
17300811-3	2007	In this study, we investigated the effect of levofloxacin on lipopolysaccharide (LPS)-induced production of interleukin-1beta (IL-1beta) in RAW264.7 cells.	Levofloxacin	45-57	interleukin 1 beta	Mus musculus	108-125
17300811-3	2007	In this study, we investigated the effect of levofloxacin on lipopolysaccharide (LPS)-induced production of interleukin-1beta (IL-1beta) in RAW264.7 cells.	Levofloxacin	45-57	interleukin 1 beta	Mus musculus	127-135
17300811-4	2007	We showed that LPS-stimulated release of pre-synthesized IL-1beta was promoted by levofloxacin, in part via the p38 mitogen-activated protein kinase (MAPK) pathway.	Levofloxacin	82-94	interleukin 1 beta	Mus musculus	57-65
17300811-5	2007	On the other hand, newly synthesized IL-1beta production was inhibited by levofloxacin.	Levofloxacin	74-86	interleukin 1 beta	Mus musculus	37-45
17300811-6	2007	This immunoregulatory function of levofloxacin in the later phase as well as promotion of pre-synthesized IL-1beta release by levofloxacin in the early phase might be advantageous in the host defense to microbial pathogens.	Levofloxacin	126-138	interleukin 1 beta	Mus musculus	106-114
17588136-4	2007	RESULTS: DSS significantly decreased bodyweight, colon length, and it increased the incidence of rectal bleeding and levels of MIP-1alpha, MIP-2 and IL-1beta compared to DSS-untreated animals.	dss	9-12	interleukin 1 beta	Mus musculus	149-157
17325656-12	2007	An anti inflammatory effect of MS-275 was also confirmed through its capacity to decrease serum IL-6 and IL-1beta levels in the CIA induced mouse model.	entinostat	31-37	interleukin 1 beta	Mus musculus	105-113
17164436-3	2007	In wild-type (WT) mice, IL-1beta injection (5 microg/kg ip) increased body temperature (+1.82 degrees C at 20 min), decreased physical activity (-37% at 1 h), and produced a slight and insignificant rise (+15% at 1 h) in oxygen consumption (Vo(2)).	Oxygen	221-227	interleukin 1 beta	Mus musculus	24-32
17209138-7	2007	Eight hours after CLP, both prophylactic and therapeutic administration of PAG significantly reduced the mRNA and protein levels of IL-1beta, IL-6, TNF-alpha, monocyte chemotactic protein-1, and macrophage inflammatory protein-2 in lung and liver coupled with decreased activation and translocation of NF-kappaB in lung and liver.	propargylglycine	75-78	interleukin 1 beta	Mus musculus	132-140
17157570-3	2007	In studies to explore this hypothesis, we used a mouse calvarial injection model to (1) investigate whether mild injury caused by a daily subcutaneous injection of a glycerol-containing vehicle onto calvaria affected osteoblast/bone formation-associated histomorphometric parameters and gene expression (mRNA encoding GAL, GAL receptors, TNFalpha, IL-1beta, collagen type I, MMP-2 and -13) compared to non-injected, control mice and (2) determine the effect of GAL+vehicle treatment on these entities.	Glycerol	166-174	interleukin 1 beta	Mus musculus	348-356
17461468-5	2007	Activated NF-kappaB level and IL-1beta and TNF-alpha levels were significantly lower in DSS+PDTC-treated group II.	dss	88-91	interleukin 1 beta	Mus musculus	30-38
17234424-4	2007	Compared with WT mice, TNF-alpha KO mice treated with MPTP showed reduced FITC-LA leakage, decreased numbers of activated microglia, and reduced proinflammatory cytokines (TNF-alpha and interleukin 1beta) associated with significant MPTP-induced DA neuron loss.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	54-58	interleukin 1 beta	Mus musculus	186-203
17414419-10	2007	Renal cortices of isoflurane-treated mice had significantly reduced expression of intercellular adhesion molecule 1, TNF-alpha, and IL-1beta messenger RNA and showed less apoptosis.	Isoflurane	18-28	interleukin 1 beta	Mus musculus	132-140
17321468-3	2007	When cells are pre-treated with Con A and subsequently treated with TLR ligands--Zymosan A, PolyI:C, LPS, CpG DNA, there is enhanced production of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-12 and IFN-gamma,), nitric oxide and iNOS expression in murine peritoneal macrophages.	Zymosan	81-90	interleukin 1 beta	Mus musculus	185-193
17321468-3	2007	When cells are pre-treated with Con A and subsequently treated with TLR ligands--Zymosan A, PolyI:C, LPS, CpG DNA, there is enhanced production of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-12 and IFN-gamma,), nitric oxide and iNOS expression in murine peritoneal macrophages.	Poly I	92-97	interleukin 1 beta	Mus musculus	185-193
17084586-0	2007	Interleukin-1beta expression in murine J774A.1 macrophages exposed to platinum compounds: the role of p38 and ERK 1/2 mitogen-activated protein kinases.	Platinum	70-78	interleukin 1 beta	Mus musculus	0-17
17084586-6	2007	While increased expression of IL-1beta mRNA was observed in the macrophages exposed to each test compound, IL-1beta protein production was detected in cell lysates after treatment with TCPP, TCPA and HCPA for 24h (concentration range of 150-350 microM) as well as for 2h (450-650 microM).	tetracarboxyphenylporphine	185-189	interleukin 1 beta	Mus musculus	107-115
17084586-6	2007	While increased expression of IL-1beta mRNA was observed in the macrophages exposed to each test compound, IL-1beta protein production was detected in cell lysates after treatment with TCPP, TCPA and HCPA for 24h (concentration range of 150-350 microM) as well as for 2h (450-650 microM).	chlorfenac	191-195	interleukin 1 beta	Mus musculus	107-115
17084586-6	2007	While increased expression of IL-1beta mRNA was observed in the macrophages exposed to each test compound, IL-1beta protein production was detected in cell lysates after treatment with TCPP, TCPA and HCPA for 24h (concentration range of 150-350 microM) as well as for 2h (450-650 microM).	Cloxyfonac	200-204	interleukin 1 beta	Mus musculus	30-38
17084586-6	2007	While increased expression of IL-1beta mRNA was observed in the macrophages exposed to each test compound, IL-1beta protein production was detected in cell lysates after treatment with TCPP, TCPA and HCPA for 24h (concentration range of 150-350 microM) as well as for 2h (450-650 microM).	Cloxyfonac	200-204	interleukin 1 beta	Mus musculus	107-115
17084586-6	2007	While increased expression of IL-1beta mRNA was observed in the macrophages exposed to each test compound, IL-1beta protein production was detected in cell lysates after treatment with TCPP, TCPA and HCPA for 24h (concentration range of 150-350 microM) as well as for 2h (450-650 microM).	Deuterium	268-270	interleukin 1 beta	Mus musculus	107-115
17084586-8	2007	Blocking the activation of p38 MAPK as well as ERK 1/2 with specific inhibitors (SB203580 and U0126, respectively) down-regulated the IL-1beta expression.	SB 203580	81-89	interleukin 1 beta	Mus musculus	134-142
17084586-8	2007	Blocking the activation of p38 MAPK as well as ERK 1/2 with specific inhibitors (SB203580 and U0126, respectively) down-regulated the IL-1beta expression.	U 0126	94-99	interleukin 1 beta	Mus musculus	134-142
17084586-10	2007	These data suggest that p38 MAPK and ERK 1/2 play an important role in induction of IL-1beta expression in J774A.1 macrophages exposed to test platinum compounds.	Platinum	143-151	interleukin 1 beta	Mus musculus	84-92
17397543-4	2007	DSS colitis in the VDR KO mice was accompanied by high colonic expression of TNF-alpha, IL-1 alpha, IL-1beta, IL-12, IFN-gamma, IL-10, MIP-1alpha and KC.	dss	0-3	interleukin 1 beta	Mus musculus	100-108
17286740-0	2007	Melatonin decreases nitric oxide production and lipid peroxidation and increases interleukin-1 beta in the brain of mice infected by the Venezuelan equine encephalomyelitis virus.	Melatonin	0-9	interleukin 1 beta	Mus musculus	81-99
17327431-9	2007	Treatment with irbesartan attenuated LV dysfunction, IL1beta, TGFbeta, and cardiac fibrosis compared with untreated diabetic animals and normalized MMP activity.	Irbesartan	15-25	interleukin 1 beta	Mus musculus	53-60
17429166-8	2007	Pretreatment with PDTC (120 mg/kg, 30 min before PFIB exposure) resulted in a significant inhibitive effect on the activation of NF-kappaB (0.5 h post PFIB exposure) and expression of IL-1beta and IL-8 (1 h post PFIB exposure).	pyrrolidine dithiocarbamic acid	18-22	interleukin 1 beta	Mus musculus	184-192
17286740-2	2007	In addition, melatonin can induces the production of interleukin-1 beta (IL-1beta), a cytokine capable of inducing increased expression of inducible nitric oxide synthase; the activity of this enzyme is increased in the brain of mice infected with VEE virus.	Melatonin	13-22	interleukin 1 beta	Mus musculus	53-71
17286740-2	2007	In addition, melatonin can induces the production of interleukin-1 beta (IL-1beta), a cytokine capable of inducing increased expression of inducible nitric oxide synthase; the activity of this enzyme is increased in the brain of mice infected with VEE virus.	Melatonin	13-22	interleukin 1 beta	Mus musculus	73-81
17166728-2	2007	We have previously shown that pretreatment of newborn mice with systemic interleukin-1-beta exacerbates ibotenate-induced excitotoxic brain lesions.	Ibotenic Acid	104-113	interleukin 1 beta	Mus musculus	73-91
17166728-5	2007	Pups pretreated with interleukin-1-beta developed greater ibotenate-induced brain damage than controls, an effect blocked by the co-administration of nimesulide (cyclooxygenase-2 inhibitor) or indomethacin (cyclooxygenase-1 and -2 inhibitor).	Ibotenic Acid	58-67	interleukin 1 beta	Mus musculus	21-39
17166728-5	2007	Pups pretreated with interleukin-1-beta developed greater ibotenate-induced brain damage than controls, an effect blocked by the co-administration of nimesulide (cyclooxygenase-2 inhibitor) or indomethacin (cyclooxygenase-1 and -2 inhibitor).	nimesulide	150-160	interleukin 1 beta	Mus musculus	21-39
17166728-5	2007	Pups pretreated with interleukin-1-beta developed greater ibotenate-induced brain damage than controls, an effect blocked by the co-administration of nimesulide (cyclooxygenase-2 inhibitor) or indomethacin (cyclooxygenase-1 and -2 inhibitor).	Indomethacin	193-205	interleukin 1 beta	Mus musculus	21-39
17166728-6	2007	Cyclooxygenase inhibitor administration prevented the interleukin-1-beta-induced increase in the production of brain prostaglandin E(2) (a cyclooxygenase metabolite) and changes in the expression of brain interleukin-6, interleukin-18, tumor necrosis factor-alpha, and brain-derived neurotrophic factor.	Dinoprostone	117-135	interleukin 1 beta	Mus musculus	54-72
17095756-8	2007	IL-1beta, CCR2, MCP-1, and inducible nitric oxide synthase mRNA levels in colons of PPAR-gamma(DeltaMphi) mice treated with DSS were higher than in similarly treated PPAR-gamma(F/F) mice.	Dextran Sulfate	124-127	interleukin 1 beta	Mus musculus	0-8
17250625-12	2007	However, IL-1beta demonstrated significantly lower peak levels at 6 hours postinjury in wounds from ethanol-treated mice, 58% less than wounds from controls.	Ethanol	100-107	interleukin 1 beta	Mus musculus	9-17
17250625-13	2007	CONCLUSION: These studies reveal that early dermal inflammatory responses including MPO activity, production of MIP-2, KC, and IL-1beta are impaired in mice given ethanol before injury, which may also have detrimental affects on later stages of wound healing.	Ethanol	163-170	interleukin 1 beta	Mus musculus	127-135
17207896-0	2007	Neuropeptide Y regulates catecholamine release evoked by interleukin-1beta in mouse chromaffin cells.	Catecholamines	25-38	interleukin 1 beta	Mus musculus	57-74
17258730-12	2007	Cytokine profiles of DCs isolated from ethanol-fed mice were characterized by enhanced interleukin (IL)-1beta and IL-10 and decreased tumor necrosis factor alpha, IL-12, interferon gamma, and IL-6 secretion.	Ethanol	39-46	interleukin 1 beta	Mus musculus	87-109
17237430-3	2007	KC, IL-6 and IL-1beta were increased (p &lt; or = 0.05) in bronchoalveolar lavage fluid (BALF) from asbestos-exposed mice, but to a lesser extent (p &lt; or = 0.05) in Tg(+) vs Tg(-) mice.	Asbestos	100-108	interleukin 1 beta	Mus musculus	13-21
17266736-7	2007	NMDA increased the expression of interleukin-1beta and TNF-alpha, and endothelial adhesion molecules, including ICAM-1, and induced leukocyte accumulation in the retinal vessels.	N-Methylaspartate	0-4	interleukin 1 beta	Mus musculus	33-50
16996249-6	2007	Treatment of RAW cells with the exchange protein directly activated by cAMP (EPAC) agonist also resulted in the up-regulation of IL-1beta and IL-6 transcripts.	Cyclic AMP	71-75	interleukin 1 beta	Mus musculus	129-137
16996249-6	2007	Treatment of RAW cells with the exchange protein directly activated by cAMP (EPAC) agonist also resulted in the up-regulation of IL-1beta and IL-6 transcripts.	epac	77-81	interleukin 1 beta	Mus musculus	129-137
17229471-3	2007	PCBs induced inflammatory responses in C57BL/6 adult male mice, significantly elevating serum levels of IL-6 (31%), IL-1beta (71%) and TNF-alpha (22%) and significantly reducing striatal dopamine (DA, 21%), tyrosine hydroxylase (TH, 26%), dopamine transporter (DAT, 39%), and synaptophysin (29%) concentrations.	Polychlorinated Biphenyls	0-4	interleukin 1 beta	Mus musculus	116-124
17207896-0	2007	Neuropeptide Y regulates catecholamine release evoked by interleukin-1beta in mouse chromaffin cells.	chromaffin	84-94	interleukin 1 beta	Mus musculus	57-74
17207896-4	2007	The aim of the present study was to determine the interaction between NPY and IL-1beta in catecholamine (norepinephrine, NE and epinephrine, EP) release from mouse chromaffin cells in culture.	Catecholamines	90-103	interleukin 1 beta	Mus musculus	78-86
17207896-4	2007	The aim of the present study was to determine the interaction between NPY and IL-1beta in catecholamine (norepinephrine, NE and epinephrine, EP) release from mouse chromaffin cells in culture.	Norepinephrine	105-119	interleukin 1 beta	Mus musculus	78-86
17207896-4	2007	The aim of the present study was to determine the interaction between NPY and IL-1beta in catecholamine (norepinephrine, NE and epinephrine, EP) release from mouse chromaffin cells in culture.	Epinephrine	108-119	interleukin 1 beta	Mus musculus	78-86
17207896-5	2007	We found that IL-1beta increased the constitutive release of NPY, NE and EP from mouse chromaffin cells.	chromaffin	87-97	interleukin 1 beta	Mus musculus	14-22
17207896-7	2007	The immunoneutralization of NPY and the use of the NPY Y(1) receptor antagonist (BIBP 3226) inhibited the stimulatory effect of IL-1beta on catecholamine release from these cells.	BIBP 3226	81-90	interleukin 1 beta	Mus musculus	128-136
17207896-7	2007	The immunoneutralization of NPY and the use of the NPY Y(1) receptor antagonist (BIBP 3226) inhibited the stimulatory effect of IL-1beta on catecholamine release from these cells.	Catecholamines	140-153	interleukin 1 beta	Mus musculus	128-136
17207896-8	2007	The present work shows that IL-1beta induces catecholamine release, and in turn this peptide will induce an additional increase in catecholamine release acting through the Y(1) receptor.	Catecholamines	45-58	interleukin 1 beta	Mus musculus	28-36
17207896-8	2007	The present work shows that IL-1beta induces catecholamine release, and in turn this peptide will induce an additional increase in catecholamine release acting through the Y(1) receptor.	Catecholamines	131-144	interleukin 1 beta	Mus musculus	28-36
17121814-0	2007	Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway.	maitotoxin	22-32	interleukin 1 beta	Mus musculus	56-73
17121814-0	2007	Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway.	Nigericin	38-47	interleukin 1 beta	Mus musculus	56-73
16949230-7	2007	inhibited the leukocyte, neutrophils, myeloperoxidase, nitric oxide, TNFalpha and IL-1beta levels (P&lt;0.01) in the pleurisy induced by carrageenan.	Carrageenan	137-148	interleukin 1 beta	Mus musculus	82-90
17121814-2	2007	Blockade of pannexin-1 in macrophage endogenously expressing the ATP-gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of interleukin-1beta (IL-1beta) in response to P2X7R activation.	Adenosine Triphosphate	65-68	interleukin 1 beta	Mus musculus	197-214
17121814-2	2007	Blockade of pannexin-1 in macrophage endogenously expressing the ATP-gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of interleukin-1beta (IL-1beta) in response to P2X7R activation.	Adenosine Triphosphate	65-68	interleukin 1 beta	Mus musculus	216-224
17121814-4	2007	We have pursued this hypothesis by measuring dye uptake and IL-1beta processing and release in mouse J774 macrophage in response to P2X7R activation and to maitotoxin and nigericin, two agents considered to evoke IL-1beta release via the same mechanism.	Nigericin	171-180	interleukin 1 beta	Mus musculus	60-68
17121814-10	2007	Thus, although pannexin-1 is required for IL-1beta release in response to maitotoxin, nigericin, and ATP, a mechanism distinct from pannexin-1 hemichannel activation must underlie the former two processes.	Nigericin	86-95	interleukin 1 beta	Mus musculus	42-50
17121814-10	2007	Thus, although pannexin-1 is required for IL-1beta release in response to maitotoxin, nigericin, and ATP, a mechanism distinct from pannexin-1 hemichannel activation must underlie the former two processes.	Adenosine Triphosphate	101-104	interleukin 1 beta	Mus musculus	42-50
17113578-6	2007	Scropolioside A also inhibited the production of prostaglandin E2, leukotriene B4, nitric oxide, interleukin-1beta, interleukin-2, interleukin-4, tumour necrosis factor-alpha and interferon-gamma, but had no effect on the production of interleukin-10.	scropolioside A	0-15	interleukin 1 beta	Mus musculus	97-114
16946079-1	2007	Recent work demonstrated that the febrile response to peripheral immune stimulation with proinflammatory cytokine IL-1beta or bacterial wall lipopolysaccharide (LPS) is mediated by induced synthesis of prostaglandin E(2) by the terminal enzyme microsomal prostaglandin E synthase-1 (mPGES-1).	Prostaglandins E	202-217	interleukin 1 beta	Mus musculus	114-122
17202374-7	2007	rVIP- vs PBS-treated B6 mice also demonstrated down-regulation of corneal mRNA and/or protein levels for proinflammatory cytokines/chemokines: IFN-gamma, IL-1beta, MIP-2, and TNF-alpha, whereas anti-inflammatory mediators, IL-10 and TGF-beta1, were up-regulated.	Lead	9-12	interleukin 1 beta	Mus musculus	154-162
17721644-6	2007	Citalopram at 10(-6) mol/l tended to inhibit the production of IL-1beta by the XS52 cell line.	Citalopram	0-10	interleukin 1 beta	Mus musculus	63-71
17202674-4	2007	Of the tested compounds, styraxoside A was found to most potently inhibit the productions of NO and PGE2, and also significantly reduced the release of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	styraxoside A	25-38	interleukin 1 beta	Mus musculus	196-213
17097618-7	2007	The levels of interleukin (IL)-1beta, tumor necrosis factor alpha and IL-6 were also decreased by triptolide in the joint tissues and sera as well as the suppression of CIA-mediated expression of their mRNAs in the joints.	triptolide	98-108	interleukin 1 beta	Mus musculus	14-36
17202674-4	2007	Of the tested compounds, styraxoside A was found to most potently inhibit the productions of NO and PGE2, and also significantly reduced the release of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	styraxoside A	25-38	interleukin 1 beta	Mus musculus	215-223
17202674-7	2007	Taken together, our data indicate that styraxoside A inhibits LPS-induced iNOS, COX-2, TNF-alpha, and IL-1beta expressions through the down-regulation of NF-kappaB-DNA binding activity.	styraxoside A	39-52	interleukin 1 beta	Mus musculus	102-110
17135359-5	2007	When compared with bleomycin-treated GITR+/+ mice, bleomycin-treated GITR-/- mice exhibited a reduced degree of i) lung infiltration with polymorphonuclear neutrophils (MPO activity); ii) edema formation; iii) histological evidence of lung injury; iv) TNF-alpha and interleukin (IL)-1beta production; v) nitrotyrosine formation; and vi) NF-kappaB activation.	Bleomycin	51-60	interleukin 1 beta	Mus musculus	266-288
17192486-4	2007	First, we investigated the effect of agents known to inhibit caspase-1 (minocycline and tetracycline) on IL-1beta production and retinal capillary degeneration in diabetic and galactose-fed mice.	Minocycline	72-83	interleukin 1 beta	Mus musculus	105-113
17192486-4	2007	First, we investigated the effect of agents known to inhibit caspase-1 (minocycline and tetracycline) on IL-1beta production and retinal capillary degeneration in diabetic and galactose-fed mice.	Tetracycline	88-100	interleukin 1 beta	Mus musculus	105-113
17192486-7	2007	At 2 months of diabetes, minocycline inhibited hyperglycemia-induced caspase-1 activity and IL-1beta production in the retina.	Minocycline	25-36	interleukin 1 beta	Mus musculus	92-100
20306664-0	2007	Role of interleukin-1beta and nitric oxide in the antiinflammatory dynamics of acetylsalicylic acid in carrageenan-induced paw oedema model.	Aspirin	79-99	interleukin 1 beta	Mus musculus	8-25
20306664-1	2007	The present study aimed to analyze the role of interleukin-1beta (IL-1beta) and nitric oxide (NO) in the development of peripheral acute inflammation in carrageenan-induced paw edema model in the presence/absence of acetyl salicylic acid (ASA).	Carrageenan	153-164	interleukin 1 beta	Mus musculus	47-64
20306664-1	2007	The present study aimed to analyze the role of interleukin-1beta (IL-1beta) and nitric oxide (NO) in the development of peripheral acute inflammation in carrageenan-induced paw edema model in the presence/absence of acetyl salicylic acid (ASA).	Carrageenan	153-164	interleukin 1 beta	Mus musculus	66-74
20306664-5	2007	Carrageenan administration induced a dose-dependent increase in paw volume, IL-1beta level in paw infiltrate and nitrite content in plasma.	Carrageenan	0-11	interleukin 1 beta	Mus musculus	76-84
20306664-7	2007	Pre-treatment with ASA resulted in increase in plasma IL-1beta level, decrease in IL-1beta level at the inflammation site and restoring plasma nitrite concentration to its normal range.	Aspirin	19-22	interleukin 1 beta	Mus musculus	54-62
20306664-7	2007	Pre-treatment with ASA resulted in increase in plasma IL-1beta level, decrease in IL-1beta level at the inflammation site and restoring plasma nitrite concentration to its normal range.	Aspirin	19-22	interleukin 1 beta	Mus musculus	82-90
20306664-8	2007	Our results stressed on the role of IL-1beta and NO in the acute inflammation and suggested that the dose of carrageenan is the major determinant in the response to ASA.	Carrageenan	109-120	interleukin 1 beta	Mus musculus	36-44
17107731-7	2007	Rosi suppressed the inflammation-induced nuclear export of RXRalpha, in both LPS-injected mice and IL-1beta-treated HepG2 cells, leading to maintenance of nuclear RXRalpha levels and heterodimer binding activity.	Rosiglitazone	0-4	interleukin 1 beta	Mus musculus	99-107
17849266-6	2007	In addition, sulforaphane significantly downregulated the serum levels of proinflammatory cytokines such as IL-1beta, IL-6, TNF-alpha, and GM-CSF during metastasis.	sulforaphane	13-25	interleukin 1 beta	Mus musculus	108-116
17849266-7	2007	These data clearly suggest that sulforaphane effectively inhibited the spread of metastatic tumor cells through the stimulation of CMI, upregulation of IL-2 and IFN-gamma, and downregulation of proinflammatory cytokines IL-1beta, IL-6, TNF-alpha, and GM-CSF.	sulforaphane	32-44	interleukin 1 beta	Mus musculus	220-228
18274640-10	2007	Both PDE4 inhibitors, KF66490 and SB207499, suppressed the production of IL-1beta, TNF-alpha, and IL-12, and the increase in myeloperoxidase activity, a marker enzyme for neutrophils and hydroxyproline content.	4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid	22-29	interleukin 1 beta	Mus musculus	73-81
17023558-6	2007	Morphine significantly reduced macrophage production of the proinflammatory cytokines IL-1beta, TNF-alpha, and IL-12 in WT animals, and the drug failed to diminish the production of these cytokines in the RelB-/- mice.	Morphine	0-8	interleukin 1 beta	Mus musculus	86-94
18274640-10	2007	Both PDE4 inhibitors, KF66490 and SB207499, suppressed the production of IL-1beta, TNF-alpha, and IL-12, and the increase in myeloperoxidase activity, a marker enzyme for neutrophils and hydroxyproline content.	Cilomilast	34-42	interleukin 1 beta	Mus musculus	73-81
17064958-2	2006	Activation of BMMC by SCF, IL-1beta and IL-10 elicits a delayed phase of PGD(2) generation dependent on cyclooxygenase (COX) 2 induction.	Prostaglandin D2	73-79	interleukin 1 beta	Mus musculus	27-35
16990558-9	2006	Expression of IL-1beta, a key inducer of ICOSL expression, was significantly reduced in mice treated with anti-ICOS antibody or soluble form of ICOS (ICOSIg) and in ICOS-deficient mice.	icosig	150-156	interleukin 1 beta	Mus musculus	14-22
16899235-1	2006	BACKGROUND: Lipoteichoic acid (LTA) and lipopolysaccharide (LPS), the toxicants from bacteria, are potent inducers of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1).	lipoteichoic acid	12-29	interleukin 1 beta	Mus musculus	188-205
16899235-1	2006	BACKGROUND: Lipoteichoic acid (LTA) and lipopolysaccharide (LPS), the toxicants from bacteria, are potent inducers of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1).	lipoteichoic acid	31-34	interleukin 1 beta	Mus musculus	188-205
17133481-9	2006	Mechanistic investigations revealed that hepatic message levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta); IL-6, and IL-8 were significantly higher in halothane-treated Balb/c mice compared to DBA/1 and C57BL/6J mice.	Halothane	182-191	interleukin 1 beta	Mus musculus	108-125
16959849-2	2006	IL-1beta can repress renin transcription under both baseline and retinoic acid-stimulated conditions in As4.1 cells, a renin-expressing cell line derived from the kidney.	Tretinoin	65-78	interleukin 1 beta	Mus musculus	0-8
16959849-4	2006	Three tandem copies of the retinoic acid response element is sufficient to attenuate the retinoic acid-response by IL-1beta.	Tretinoin	27-40	interleukin 1 beta	Mus musculus	115-123
16959849-4	2006	Three tandem copies of the retinoic acid response element is sufficient to attenuate the retinoic acid-response by IL-1beta.	Tretinoin	89-102	interleukin 1 beta	Mus musculus	115-123
16959849-5	2006	The decrease in retinoic acid-induced renin promoter activity in response to IL-1beta was blocked with the general tyrosine kinase inhibitor Genistein.	Tretinoin	16-29	interleukin 1 beta	Mus musculus	77-85
16959849-5	2006	The decrease in retinoic acid-induced renin promoter activity in response to IL-1beta was blocked with the general tyrosine kinase inhibitor Genistein.	Genistein	141-150	interleukin 1 beta	Mus musculus	77-85
16959849-7	2006	PD98059, an Erk kinase inhibitor, significantly decreased IL-1beta-mediated phosphorylation of ERK1/2, and attenuated the repression of baseline renin transcription in response to IL-1beta.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	interleukin 1 beta	Mus musculus	58-66
16959849-7	2006	PD98059, an Erk kinase inhibitor, significantly decreased IL-1beta-mediated phosphorylation of ERK1/2, and attenuated the repression of baseline renin transcription in response to IL-1beta.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	interleukin 1 beta	Mus musculus	180-188
16959849-8	2006	PD98059 partially reversed the IL-1beta effect on retinoic acid-mediated transcription.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	interleukin 1 beta	Mus musculus	31-39
16959849-8	2006	PD98059 partially reversed the IL-1beta effect on retinoic acid-mediated transcription.	Tretinoin	50-63	interleukin 1 beta	Mus musculus	31-39
16959849-10	2006	Although there was no effect of IL-1beta on the phosphorylation of ELK, Janus kinase 2, or signal transducers and activators of transcription (STAT) 1, IL-1beta significantly increased tyrosine-phosphorylation of STAT3, an effect attenuated by PD98059.	Tyrosine	185-193	interleukin 1 beta	Mus musculus	152-160
16959849-10	2006	Although there was no effect of IL-1beta on the phosphorylation of ELK, Janus kinase 2, or signal transducers and activators of transcription (STAT) 1, IL-1beta significantly increased tyrosine-phosphorylation of STAT3, an effect attenuated by PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	244-251	interleukin 1 beta	Mus musculus	152-160
17133481-9	2006	Mechanistic investigations revealed that hepatic message levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta); IL-6, and IL-8 were significantly higher in halothane-treated Balb/c mice compared to DBA/1 and C57BL/6J mice.	Halothane	182-191	interleukin 1 beta	Mus musculus	127-135
16908867-7	2006	Importantly, IL-1beta/IL-18 double knockout mice were protected from splenic cell apoptosis and sepsis-induced mortality by the caspase inhibitor zVAD-fmk.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	146-154	interleukin 1 beta	Mus musculus	13-21
16765619-6	2006	The elevated levels of Th(1) cytokines, namely TNF-alpha, IL-1beta, IFN-gamma, nitrite, and iNOS, decreased significantly both at +4 and +24 h of WBH, following L-arg administration.	wbh	146-149	interleukin 1 beta	Mus musculus	58-66
17119390-9	2006	RESULTS: Guggulsterone significantly inhibited LPS- or IL-1beta-induced ICAM-1 gene expression, NF-kappaB transcriptional activity, IkappaB phosphorylation/degradation, and NF-kappaB DNA binding activity in IEC.	pregna-4,17-diene-3,16-dione	9-22	interleukin 1 beta	Mus musculus	55-63
16985210-6	2006	This renal protective effect of pentoxifylline was associated with an inhibition of the rise in serum TNF-alpha (1.00 +/- 0.55 vs. 7.02 +/- 2.40 pg/ml, P &lt; 0.05) and serum IL-1beta (31.3 +/- 3.6 vs. 53.3 +/- 5.9 pg/ml, P &lt; 0.01) induced by LPS.	Pentoxifylline	32-46	interleukin 1 beta	Mus musculus	175-183
16985210-12	2006	Thus pentoxifylline, an FDA-approved drug, protects against endotoxemia-related ARF and involves a decrease in serum TNF-alpha, IL-1beta, and NO as well as a decrease in renal iNOS and ICAM-1.	Pentoxifylline	5-19	interleukin 1 beta	Mus musculus	128-136
16978829-5	2006	Using enzyme-linked immunosorbent assays (ELISAs) we showed DHMEQ to inhibit LPS-induced secretion of IL-6, IL-12, interleukin-1beta (IL-1beta), and TNF-alpha.	dehydroxymethylepoxyquinomicin	60-65	interleukin 1 beta	Mus musculus	115-132
16806046-2	2006	Annexin-V/propidium iodine double-staining analysis demonstrated that the combination of tumour necrosis factor-alpha, interleukin-1beta and interferon-gamma caused cell death in osteoblastic cells mediated by apoptosis, not necrosis.	Propidium	10-26	interleukin 1 beta	Mus musculus	119-136
16978829-5	2006	Using enzyme-linked immunosorbent assays (ELISAs) we showed DHMEQ to inhibit LPS-induced secretion of IL-6, IL-12, interleukin-1beta (IL-1beta), and TNF-alpha.	dehydroxymethylepoxyquinomicin	60-65	interleukin 1 beta	Mus musculus	134-142
16978829-6	2006	Furthermore, DHMEQ also inhibited the phagocytosis of fluorescently labeled Escherichia coli by RAW264.7 cells treated with LPS or IL-1beta, thus being the first evidence for the involvement of NF-kappaB in the regulation of phagocytosis by use of this inhibitor.	dehydroxymethylepoxyquinomicin	13-18	interleukin 1 beta	Mus musculus	131-139
17174561-2	2006	Inhibition of AR by three distinct AR inhibitors sorbinil, tolrestat or zopolrestat suppressed the LPS-induced production of inflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, IFN-gamma, and chemokine MCP-1 in murine peritoneal macrophages.	sorbinil	49-57	interleukin 1 beta	Mus musculus	173-181
17016509-4	2006	EXPERIMENTAL APPROACH: Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by: accumulation of fluid containing a large number of neutrophils (PMNs) in the pleural cavity, infiltration of PMNs in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate (NOx), prostaglandin E2 (PGE2), tumour necrosis factor-alpha, (TNF-alpha) and interleukin-1beta (IL-1beta).	Carrageenan	36-47	interleukin 1 beta	Mus musculus	425-442
17016509-4	2006	EXPERIMENTAL APPROACH: Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by: accumulation of fluid containing a large number of neutrophils (PMNs) in the pleural cavity, infiltration of PMNs in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate (NOx), prostaglandin E2 (PGE2), tumour necrosis factor-alpha, (TNF-alpha) and interleukin-1beta (IL-1beta).	Carrageenan	36-47	interleukin 1 beta	Mus musculus	444-452
17174561-2	2006	Inhibition of AR by three distinct AR inhibitors sorbinil, tolrestat or zopolrestat suppressed the LPS-induced production of inflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, IFN-gamma, and chemokine MCP-1 in murine peritoneal macrophages.	tolrestat	59-68	interleukin 1 beta	Mus musculus	173-181
17174561-2	2006	Inhibition of AR by three distinct AR inhibitors sorbinil, tolrestat or zopolrestat suppressed the LPS-induced production of inflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, IFN-gamma, and chemokine MCP-1 in murine peritoneal macrophages.	zopolrestat	72-83	interleukin 1 beta	Mus musculus	173-181
17023266-4	2006	Furthermore, oh(8)dG reduced mRNA levels of pro-inflammatory cytokine, such as IL-1beta, IL-6, and TNF-alpha, in activated BV2 cells.	oh(8)dg	13-20	interleukin 1 beta	Mus musculus	79-87
17023389-4	2006	The results show that genetic deletion of mPGES-1 results in a dramatic decrease in PGE2 production in Het and null MEFs under basal conditions and after stimulation with interleukin (IL)-1beta, suggesting that mPGES-1 is critically important for PGE2 production.	Dinoprostone	84-88	interleukin 1 beta	Mus musculus	171-193
17122962-14	2006	The increase in TNF-alpha, IL-1beta and CXCL8/IL-8 levels that were detected in knee synovial extracts obtained from zymosan-stimulated mice was also inhibited by TNTP (100 mg/kg, p.	Zymosan	117-124	interleukin 1 beta	Mus musculus	27-35
17023389-4	2006	The results show that genetic deletion of mPGES-1 results in a dramatic decrease in PGE2 production in Het and null MEFs under basal conditions and after stimulation with interleukin (IL)-1beta, suggesting that mPGES-1 is critically important for PGE2 production.	Dinoprostone	247-251	interleukin 1 beta	Mus musculus	171-193
17122962-14	2006	The increase in TNF-alpha, IL-1beta and CXCL8/IL-8 levels that were detected in knee synovial extracts obtained from zymosan-stimulated mice was also inhibited by TNTP (100 mg/kg, p.	Limonins	163-167	interleukin 1 beta	Mus musculus	27-35
17003335-11	2006	Consistent with our in vitro results, IL-1beta knockout mice displayed glucose intolerance along with a decrease in islet Fas, FLIP, Pax4, and PDX-1 transcripts.	Glucose	71-78	interleukin 1 beta	Mus musculus	38-46
17092423-8	2006	While in carbachol treatment group, the number of splenic DC had no significant change, the expression of IL-1 beta was down-regulated, dramatically.	Carbachol	9-18	interleukin 1 beta	Mus musculus	106-115
17035503-7	2006	These findings, together with the present demonstration that this effect is integrated in the brain and is paralleled by IL-1beta expression in the hypothalamus, indicate that this cytokine can reset glucose homeostasis at central levels.	Glucose	200-207	interleukin 1 beta	Mus musculus	121-129
16806825-0	2006	Effects of interleukin-1beta on hippocampal glutamate and GABA releases associated with Ca2+-induced Ca2+ releasing systems.	Glutamic Acid	44-53	interleukin 1 beta	Mus musculus	11-28
16924582-4	2006	Our data also indicate that gigantol is a potent inhibitor of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) release and influenced the mRNA expression levels of these cytokines in a dose-dependent manner.	gigantol	28-36	interleukin 1 beta	Mus musculus	103-120
16806825-0	2006	Effects of interleukin-1beta on hippocampal glutamate and GABA releases associated with Ca2+-induced Ca2+ releasing systems.	gamma-Aminobutyric Acid	58-62	interleukin 1 beta	Mus musculus	11-28
16806825-2	2006	To clarify this mechanism, the present study determined the effects of IL-1beta on Ca2+-associated releases of glutamate and GABA in mouse hippocampus.	Glutamic Acid	111-120	interleukin 1 beta	Mus musculus	71-79
16806825-2	2006	To clarify this mechanism, the present study determined the effects of IL-1beta on Ca2+-associated releases of glutamate and GABA in mouse hippocampus.	gamma-Aminobutyric Acid	125-129	interleukin 1 beta	Mus musculus	71-79
16806825-5	2006	IL-1beta increased basal releases of glutamate and GABA depending on the activation of Ca2+ influx and ryanodine receptor (RyR)-sensitive CICR, but reduced K+-evoked releases depending on Ca2+ influx, RyR-sensitive and inositol 1,4,5-trisphosphate receptor (IP3R)-sensitive CICRs.	Glutamic Acid	37-46	interleukin 1 beta	Mus musculus	0-8
16806825-5	2006	IL-1beta increased basal releases of glutamate and GABA depending on the activation of Ca2+ influx and ryanodine receptor (RyR)-sensitive CICR, but reduced K+-evoked releases depending on Ca2+ influx, RyR-sensitive and inositol 1,4,5-trisphosphate receptor (IP3R)-sensitive CICRs.	gamma-Aminobutyric Acid	51-55	interleukin 1 beta	Mus musculus	0-8
16806825-5	2006	IL-1beta increased basal releases of glutamate and GABA depending on the activation of Ca2+ influx and ryanodine receptor (RyR)-sensitive CICR, but reduced K+-evoked releases depending on Ca2+ influx, RyR-sensitive and inositol 1,4,5-trisphosphate receptor (IP3R)-sensitive CICRs.	cicr	138-142	interleukin 1 beta	Mus musculus	0-8
16806825-5	2006	IL-1beta increased basal releases of glutamate and GABA depending on the activation of Ca2+ influx and ryanodine receptor (RyR)-sensitive CICR, but reduced K+-evoked releases depending on Ca2+ influx, RyR-sensitive and inositol 1,4,5-trisphosphate receptor (IP3R)-sensitive CICRs.	cicrs	274-279	interleukin 1 beta	Mus musculus	0-8
16806825-6	2006	During neuronal hyperexcitability, the effect of IL-1beta on GABA release was more predominantly modulated by Ca2+ influx and RyR-sensitive CICR than that on glutamate.	gamma-Aminobutyric Acid	61-65	interleukin 1 beta	Mus musculus	49-57
16988135-5	2006	Male vitamin C-deficient mice had higher expression of mRNA for regulated upon activation normal T expressed and secreted (RANTES), IL-1beta, and TNF-alpha in the lungs at d 1 after infection compared with male controls.	Ascorbic Acid	5-14	interleukin 1 beta	Mus musculus	132-140
16806825-6	2006	During neuronal hyperexcitability, the effect of IL-1beta on GABA release was more predominantly modulated by Ca2+ influx and RyR-sensitive CICR than that on glutamate.	cicr	140-144	interleukin 1 beta	Mus musculus	49-57
16806825-6	2006	During neuronal hyperexcitability, the effect of IL-1beta on GABA release was more predominantly modulated by Ca2+ influx and RyR-sensitive CICR than that on glutamate.	Glutamic Acid	158-167	interleukin 1 beta	Mus musculus	49-57
16806825-7	2006	These results indicate that hyperactivation of IL-1beta leads to imbalance between glutamatergic and GABAergic transmission via toxic overload response of Ca2+ influx and CICR.	cicr	171-175	interleukin 1 beta	Mus musculus	47-55
17032168-2	2006	We previously showed that LPS-induced IL-1beta expression was regulated by a Stat1-dependent, nitric oxide (NO)-mediated mechanism.	Nitric Oxide	94-106	interleukin 1 beta	Mus musculus	38-46
16924582-4	2006	Our data also indicate that gigantol is a potent inhibitor of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) release and influenced the mRNA expression levels of these cytokines in a dose-dependent manner.	gigantol	28-36	interleukin 1 beta	Mus musculus	122-130
16924582-5	2006	Furthermore, a reporter gene assay for nuclear factor kappa B (NF-kappaB) and an electromobility shift assay (EMSA) demonstrated that gigantol effectively inhibited the activation of NF-kappaB, which is necessary for the expression of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6.	gigantol	134-142	interleukin 1 beta	Mus musculus	259-267
16870144-1	2006	The imidazoline compound RX871024 reduces IL-1beta-induced NO production thereby protecting against IL-1beta-induced beta-cell apoptosis.	Imidazolines	4-15	interleukin 1 beta	Mus musculus	42-50
16777343-1	2006	Most of the inflammatory effects of the cytokine interleukin 1beta (IL-1beta) are mediated by induction of cyclooxygenase (COX)2 and the subsequent synthesis and release of prostaglandin E2.	Dinoprostone	173-189	interleukin 1 beta	Mus musculus	49-66
16777343-1	2006	Most of the inflammatory effects of the cytokine interleukin 1beta (IL-1beta) are mediated by induction of cyclooxygenase (COX)2 and the subsequent synthesis and release of prostaglandin E2.	Dinoprostone	173-189	interleukin 1 beta	Mus musculus	68-76
16777343-11	2006	Taken together our data suggest that IL-1beta inhibits the activity of preoptic area/anterior hypothalamus neurons by increasing the presynaptic release of GABA.	gamma-Aminobutyric Acid	156-160	interleukin 1 beta	Mus musculus	37-45
16890203-4	2006	The expressions of the inflammatory cytokines, IL-1alpha and IL-1beta, were reduced in the TPA-treated Tg EC-SOD compared with those in TPA-treated WT.	Tetradecanoylphorbol Acetate	91-94	interleukin 1 beta	Mus musculus	61-69
16890203-4	2006	The expressions of the inflammatory cytokines, IL-1alpha and IL-1beta, were reduced in the TPA-treated Tg EC-SOD compared with those in TPA-treated WT.	Tetradecanoylphorbol Acetate	136-139	interleukin 1 beta	Mus musculus	61-69
16890203-6	2006	The number of infiltrating inflammatory cells and the IL-1beta expressing cells was obviously reduced in TPA-treated Tg EC-SOD in comparison with TPA-treated WT.	Tetradecanoylphorbol Acetate	105-108	interleukin 1 beta	Mus musculus	54-62
16890203-7	2006	The result suggests that EC-SOD might play an important role in the suppression of TPA-induced cutaneous inflammation and epidermal hyperplasia by regulating the expression of IL-1alpha and IL-1beta, although the mechanisms remain to be elucidated.	Tetradecanoylphorbol Acetate	83-86	interleukin 1 beta	Mus musculus	190-198
16870144-1	2006	The imidazoline compound RX871024 reduces IL-1beta-induced NO production thereby protecting against IL-1beta-induced beta-cell apoptosis.	Imidazolines	4-15	interleukin 1 beta	Mus musculus	100-108
16865092-6	2006	Atorvastatin pre-treatment reduced hypernociception induced by bradykinin and cytokines (TNF-alpha, IL-1beta and KC), and the release of IL-1beta and PGE(2) in paw skin, induced by lipopolysaccharide.	Atorvastatin	0-12	interleukin 1 beta	Mus musculus	100-108
16960387-5	2006	Lipopolysaccharide-stimulated transcriptions of IL-1beta and IL-12 p40 in RAW264 were inhibited by beta-carotene but not by alpha-tocopherol.	beta Carotene	99-112	interleukin 1 beta	Mus musculus	48-56
16865092-6	2006	Atorvastatin pre-treatment reduced hypernociception induced by bradykinin and cytokines (TNF-alpha, IL-1beta and KC), and the release of IL-1beta and PGE(2) in paw skin, induced by lipopolysaccharide.	Atorvastatin	0-12	interleukin 1 beta	Mus musculus	137-145
16771830-0	2006	IL-1beta induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons.	Ceramides	39-47	interleukin 1 beta	Mus musculus	0-8
16854958-6	2006	RESULTS: Pretreatment of mice with telithromycin as well as roxithromycin similarly attenuated the LPS-induced expression and formation of TNFalpha, IL-1beta and IFNgamma.	telithromycin	35-48	interleukin 1 beta	Mus musculus	149-157
16854958-6	2006	RESULTS: Pretreatment of mice with telithromycin as well as roxithromycin similarly attenuated the LPS-induced expression and formation of TNFalpha, IL-1beta and IFNgamma.	Roxithromycin	60-73	interleukin 1 beta	Mus musculus	149-157
16771830-6	2006	These effects of IL-1beta were dependent on the association of the cytosolic adaptor protein, MyD88, to the IL-1 receptor, and on the activation of the neutral sphingomyelinase, leading to production of ceramide.	Ceramides	203-211	interleukin 1 beta	Mus musculus	17-25
16771830-7	2006	A cell-permeable analog of ceramide mimicked the effects of IL-1beta on the cultured AH neurons.	Ceramides	27-35	interleukin 1 beta	Mus musculus	60-68
16771830-8	2006	These results suggest that ceramide may be the second messenger of the fast IL-1beta actions in AH neurons, and that this IL-1beta/ceramide pathway may underlie the fast non-transcription-dependent, electrophysiological effects of IL-1beta observed in AH neurons in vivo.	Ceramides	27-35	interleukin 1 beta	Mus musculus	76-84
16771830-8	2006	These results suggest that ceramide may be the second messenger of the fast IL-1beta actions in AH neurons, and that this IL-1beta/ceramide pathway may underlie the fast non-transcription-dependent, electrophysiological effects of IL-1beta observed in AH neurons in vivo.	Ceramides	131-139	interleukin 1 beta	Mus musculus	122-130
16771830-8	2006	These results suggest that ceramide may be the second messenger of the fast IL-1beta actions in AH neurons, and that this IL-1beta/ceramide pathway may underlie the fast non-transcription-dependent, electrophysiological effects of IL-1beta observed in AH neurons in vivo.	Ceramides	131-139	interleukin 1 beta	Mus musculus	122-130
16867259-0	2006	Induction of murine interleukin-1 beta expression by water-soluble components from Hericium erinaceum.	Water	53-58	interleukin 1 beta	Mus musculus	20-38
16981403-8	2006	The mRNA levels of IL-1beta, IL-6 and COX-2 in the cerebral cortex were up-regulated 24 h after turpentine injection.	Turpentine	96-106	interleukin 1 beta	Mus musculus	19-27
16981403-9	2006	On the other hand, the up-regulated mRNA levels of IL-1beta, IL-6 and COX-2 in the cerebral cortex after turpentine treatment were not suppressed by indomethacin.	Turpentine	105-115	interleukin 1 beta	Mus musculus	51-59
16806109-2	2006	mRNA levels of IL-1beta, IL-6 and TNF-alpha before seizure and mRNA levels of IL-6 and TNF-alpha after seizure were decreased in the brains of the mice with pioglitazone.	Pioglitazone	157-169	interleukin 1 beta	Mus musculus	15-23
16867259-1	2006	AIM: To investigate the inductive effect of water extract from Hericium erinaceum (WEHE) on interleukin-1beta (IL-1beta) expression.	Water	44-49	interleukin 1 beta	Mus musculus	111-119
16774945-2	2006	AIRmax mice were more susceptible than AIRmin to acute colitis induced by ingestion of dextran sodium sulfate showing a 3-fold higher disease activity index and presenting an intense inflammatory infiltrate in the base of colon crypts as well as elevated expression of IL-1beta, TNFalpha, IFNgamma and IL-6 mRNA in colon tissue.	dextran sodium sulfate	87-109	interleukin 1 beta	Mus musculus	269-277
16964764-3	2006	These ginsenosides also reduced mRNA expressions of cyclooxygenase-2, interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma.	Ginsenosides	6-18	interleukin 1 beta	Mus musculus	70-92
16964764-5	2006	These findings suggest that ginsenoside Rh3 metabolized from ginsenoside Rg5 may improve chronic dermatitis or psoriasis by the regulation of IL-1beta and TNF-alpha produced by macrophage cells and of IFN-gamma produced by Th cells.	ginsenoside Rh3	28-43	interleukin 1 beta	Mus musculus	142-150
16964764-5	2006	These findings suggest that ginsenoside Rh3 metabolized from ginsenoside Rg5 may improve chronic dermatitis or psoriasis by the regulation of IL-1beta and TNF-alpha produced by macrophage cells and of IFN-gamma produced by Th cells.	Ginsenosides	28-39	interleukin 1 beta	Mus musculus	142-150
16547072-7	2006	Interleukin (IL)-6, IL-1beta, and tumour necrosis factor alpha mRNA levels in colons of PPARgamma(DeltaIEpC) mice treated with DSS were higher than in similarly treated PPARgamma(F/F) mice.	dss	127-130	interleukin 1 beta	Mus musculus	20-28
16513308-4	2006	Cyclooxygenase-2 (COX-2) and tyrosine kinase involve on prostaglandin E2 (PGE2) production in mouse calvarial osteoblasts stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6).	Dinoprostone	56-72	interleukin 1 beta	Mus musculus	145-162
16860713-2	2006	OBJECTIVES: This study evaluated whether the acute and systemic administration of Tacrolimus significantly interfered in leukocyte migration, exudation, myeloperoxidase and adenosine-deaminase and nitric oxide levels, as well as Interleukin-1 (IL-1beta) and tumor necrosis factor alpha (TNFalpha) levels in a mouse model of pleurisy in comparison to those obtained with dexamethasone.	Tacrolimus	82-92	interleukin 1 beta	Mus musculus	244-252
16513308-4	2006	Cyclooxygenase-2 (COX-2) and tyrosine kinase involve on prostaglandin E2 (PGE2) production in mouse calvarial osteoblasts stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6).	Dinoprostone	74-78	interleukin 1 beta	Mus musculus	145-162
16513308-6	2006	TGF-beta, YJ (100microg/ml) and their combinations of YJ+TGF-beta reduced the COX-2 mRNA level, PGE2 biosynthesis and bone resorption induced by IL-1beta, TNF-alpha, IL-6 or their combination.	Dinoprostone	96-100	interleukin 1 beta	Mus musculus	145-153
16513308-4	2006	Cyclooxygenase-2 (COX-2) and tyrosine kinase involve on prostaglandin E2 (PGE2) production in mouse calvarial osteoblasts stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6).	Dinoprostone	56-72	interleukin 1 beta	Mus musculus	164-172
16886979-5	2006	IL-1beta release was induced in mouse organotypic hippocampal slice cultures by proinflammatory stimuli [lipopolysaccharide (LPS) + adenosine triphosphate (ATP)] and measured with enzyme-linked immunosorbent assay (ELISA).	Adenosine Triphosphate	132-154	interleukin 1 beta	Mus musculus	0-8
16886979-5	2006	IL-1beta release was induced in mouse organotypic hippocampal slice cultures by proinflammatory stimuli [lipopolysaccharide (LPS) + adenosine triphosphate (ATP)] and measured with enzyme-linked immunosorbent assay (ELISA).	Adenosine Triphosphate	156-159	interleukin 1 beta	Mus musculus	0-8
16781464-9	2006	LPS-induced TNFalpha and IL-1beta secretion from macrophages of adriamycin-treated mice was decreased by 28.7 and 29.5%, respectively, compared to macrophages isolated from saline-injected mice.	Doxorubicin	64-74	interleukin 1 beta	Mus musculus	25-33
16714212-9	2006	Simultaneous treatment with EPAH indicated remarkable recovery or improvement of FM1-induced reduction of IL-1beta level and phagocytic capacity of RES.	epah	28-32	interleukin 1 beta	Mus musculus	106-114
16761958-8	2006	These results suggest that indomethacin and dexamethasone prolonged the recovery period caused by inhibition of PGD2 and IL-1beta.	Indomethacin	27-39	interleukin 1 beta	Mus musculus	121-129
16761958-8	2006	These results suggest that indomethacin and dexamethasone prolonged the recovery period caused by inhibition of PGD2 and IL-1beta.	Dexamethasone	44-57	interleukin 1 beta	Mus musculus	121-129
16827898-7	2006	Analysis by reverse transcription-polymerase chain reaction indicated that Manna, OM and RM also stimulated up-regulation of inflammatory cytokines including interleukin-1beta and tumour necrosis factor-alpha, and differential T helper 1 (Th1)/Th2 cytokines.	(1-6)-alpha-glucomannan	75-80	interleukin 1 beta	Mus musculus	158-208
16764943-8	2006	Interestingly, a combination of 9-cis RA and the PPAR-alpha agonists fenofibrate or gemfibrozil cooperatively inhibited NO, TNF-alpha, IL-1beta, IL-6, and MCP-1 production by these cells.	Radium	38-40	interleukin 1 beta	Mus musculus	135-143
16764943-8	2006	Interestingly, a combination of 9-cis RA and the PPAR-alpha agonists fenofibrate or gemfibrozil cooperatively inhibited NO, TNF-alpha, IL-1beta, IL-6, and MCP-1 production by these cells.	Fenofibrate	69-80	interleukin 1 beta	Mus musculus	135-143
16764943-8	2006	Interestingly, a combination of 9-cis RA and the PPAR-alpha agonists fenofibrate or gemfibrozil cooperatively inhibited NO, TNF-alpha, IL-1beta, IL-6, and MCP-1 production by these cells.	Gemfibrozil	84-95	interleukin 1 beta	Mus musculus	135-143
16771773-3	2006	After the induction of inflammation with TNBS, the levels of proinflammatory cytokines, such as TNF-alpha, interleukin-1beta and interleukin-6, were elevated both in the inflamed mucosa and muscle layers in the wild-type mice; however, the productions of these cytokines were greatly reduced in the TNF-alpha(-/-) mouse colon.	Trinitrobenzenesulfonic Acid	41-45	interleukin 1 beta	Mus musculus	107-124
16601113-5	2006	Interestingly, inhibition of GSK-3beta by antisense oligonucleotides or pharmacological agent (10 mm lithium) potentiated TNF-induced expression of IL-6 and MCP-1 by 2-6-fold suggesting that inhibition of GSK-3beta under inflammatory conditions (exposure to TNF-alpha and IL-1beta) may contribute to enhanced cytokine expression.	Lithium	101-108	interleukin 1 beta	Mus musculus	272-280
16627484-4	2006	Treatment with the JNK1/2 inhibitor, SP600125, abrogated the increases in mPGES-1 mRNA stability, mPGES-1 protein synthesis, and PGE(2) release induced by interleukin-1beta or LPS.	pyrazolanthrone	37-45	interleukin 1 beta	Mus musculus	155-172
16762003-2	2006	METHODS: Intraperitoneal application of a single dose of either tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta in mice led to an enhanced expression of hepatic TIMP-1 after 4-16 h. Male Sprague-Dawley rats were treated with carbon tetrachloride (CCl4) in the presence and absence of specific TNF-alpha and IL-1beta inhibitors.	Carbon Tetrachloride	237-257	interleukin 1 beta	Mus musculus	101-123
16955242-6	2006	RESULTS: In cultured synoviocytes, SP, TNF-alpha and IL-1beta induced significantly increased nitrite concentrations.	Nitrites	94-101	interleukin 1 beta	Mus musculus	53-61
16762003-2	2006	METHODS: Intraperitoneal application of a single dose of either tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta in mice led to an enhanced expression of hepatic TIMP-1 after 4-16 h. Male Sprague-Dawley rats were treated with carbon tetrachloride (CCl4) in the presence and absence of specific TNF-alpha and IL-1beta inhibitors.	Carbon Tetrachloride	259-263	interleukin 1 beta	Mus musculus	101-123
16813970-0	2006	Pathogenesis of bronchopulmonary dysplasia: the role of interleukin 1beta in the regulation of inflammation-mediated pulmonary retinoic acid pathways in transgenic mice.	Tretinoin	127-140	interleukin 1 beta	Mus musculus	56-73
16673329-4	2006	Additionally, ginsenoside Rh2 inhibited the expression of COX-2, pro-inflammatory TNF-alpha and IL-1beta in BV-2 cells induced by LPS/IFN-gamma, while it increased the expression of the anti-inflammatory cytokine IL-10.	ginsenoside Rh2	14-29	interleukin 1 beta	Mus musculus	96-104
16721267-3	2006	Pretreatment of macrophage cultures with lactacystin, a well-established proteasome inhibitor, significantly repressed tumor necrosis factor alpha secretion and tumor necrosis factor alpha and interleukin 1 beta gene expression, blocked the degradation of IkappaB, and dysregulated phosphorylation of MAPK induced by CpG DNA or PG.	lactacystin	41-52	interleukin 1 beta	Mus musculus	193-211
16813970-2	2006	To determine the mechanisms by which IL-1beta influences lung development, we have generated transgenic mice in which human IL-1beta is expressed in the lung epithelium with a doxycycline-inducible system controlled by the Clara cell secretory protein promoter.	Doxycycline	176-187	interleukin 1 beta	Mus musculus	37-45
16203021-6	2006	These results suggest that (1) there are mutual augmentations between alendronate and immuno-stimulants (IL-1, TNF, and LPS) in HDC induction, (2) tissue IL-1beta is important in alendronate-stimulated HDC induction, and (3) combination use of clodronate may have the potential to reduce the inflammatory effects of alendronate (we previously found that clodronate, conveniently, does not inhibit the anti-bone-resorptive activity of alendronate).	Alendronate	70-81	interleukin 1 beta	Mus musculus	154-162
16546114-4	2006	The fimbria-induced expression of interleukin-1beta and neutrophil chemoattractant KC genes in RAW264.7 murine macrophages was strongly inhibited by bis-BHA.	bis-bha	149-156	interleukin 1 beta	Mus musculus	34-51
16927832-5	2006	RESULTS: Diacerein significantly inhibited the formation and function of the cultured osteoclasts stimulated by IL-1beta.	diacerein	9-18	interleukin 1 beta	Mus musculus	112-120
19127725-4	2006	Using a murine-derived macrophage cell line J774A.1, we found that polysaccharide constituents of the higher molecular-weight group of RASP were able to induce interleukin-1beta (IL-1) gene expression via protein kinase-mediated signal transduction pathways.	Polysaccharides	67-81	interleukin 1 beta	Mus musculus	160-177
16619190-8	2006	IL-1 beta-/- mice showed decreased recruitment of granulocytes in response to an intraperitoneal C. albicans challenge, and generation of superoxide production was diminished in IL-1 beta-/- granulocytes.	Superoxides	138-148	interleukin 1 beta	Mus musculus	0-9
16619190-8	2006	IL-1 beta-/- mice showed decreased recruitment of granulocytes in response to an intraperitoneal C. albicans challenge, and generation of superoxide production was diminished in IL-1 beta-/- granulocytes.	Superoxides	138-148	interleukin 1 beta	Mus musculus	178-187
16203021-6	2006	These results suggest that (1) there are mutual augmentations between alendronate and immuno-stimulants (IL-1, TNF, and LPS) in HDC induction, (2) tissue IL-1beta is important in alendronate-stimulated HDC induction, and (3) combination use of clodronate may have the potential to reduce the inflammatory effects of alendronate (we previously found that clodronate, conveniently, does not inhibit the anti-bone-resorptive activity of alendronate).	Alendronate	179-190	interleukin 1 beta	Mus musculus	154-162
16203021-6	2006	These results suggest that (1) there are mutual augmentations between alendronate and immuno-stimulants (IL-1, TNF, and LPS) in HDC induction, (2) tissue IL-1beta is important in alendronate-stimulated HDC induction, and (3) combination use of clodronate may have the potential to reduce the inflammatory effects of alendronate (we previously found that clodronate, conveniently, does not inhibit the anti-bone-resorptive activity of alendronate).	Alendronate	179-190	interleukin 1 beta	Mus musculus	154-162
16203021-6	2006	These results suggest that (1) there are mutual augmentations between alendronate and immuno-stimulants (IL-1, TNF, and LPS) in HDC induction, (2) tissue IL-1beta is important in alendronate-stimulated HDC induction, and (3) combination use of clodronate may have the potential to reduce the inflammatory effects of alendronate (we previously found that clodronate, conveniently, does not inhibit the anti-bone-resorptive activity of alendronate).	Clodronic Acid	244-254	interleukin 1 beta	Mus musculus	154-162
16203021-6	2006	These results suggest that (1) there are mutual augmentations between alendronate and immuno-stimulants (IL-1, TNF, and LPS) in HDC induction, (2) tissue IL-1beta is important in alendronate-stimulated HDC induction, and (3) combination use of clodronate may have the potential to reduce the inflammatory effects of alendronate (we previously found that clodronate, conveniently, does not inhibit the anti-bone-resorptive activity of alendronate).	Alendronate	179-190	interleukin 1 beta	Mus musculus	154-162
16203021-6	2006	These results suggest that (1) there are mutual augmentations between alendronate and immuno-stimulants (IL-1, TNF, and LPS) in HDC induction, (2) tissue IL-1beta is important in alendronate-stimulated HDC induction, and (3) combination use of clodronate may have the potential to reduce the inflammatory effects of alendronate (we previously found that clodronate, conveniently, does not inhibit the anti-bone-resorptive activity of alendronate).	Clodronic Acid	354-364	interleukin 1 beta	Mus musculus	154-162
16779518-7	2006	Curcumin-treated mice also exhibited relative decreases in aortic tissue activator protein-1 and nuclear factor kappaB DNA binding activities and significantly lower aortic tissue concentrations of interleukin-1beta (IL-1beta), IL-6, monocyte chemoattractant protein-1, and matrix metalloproteinase-9 (all p &lt; 0.05).	Curcumin	0-8	interleukin 1 beta	Mus musculus	198-215
16779518-7	2006	Curcumin-treated mice also exhibited relative decreases in aortic tissue activator protein-1 and nuclear factor kappaB DNA binding activities and significantly lower aortic tissue concentrations of interleukin-1beta (IL-1beta), IL-6, monocyte chemoattractant protein-1, and matrix metalloproteinase-9 (all p &lt; 0.05).	Curcumin	0-8	interleukin 1 beta	Mus musculus	217-225
16484594-5	2006	Systemic administration of Am80 led to reductions in the areas of atherosclerotic lesions and foam cell accumulation in the aortas of apolipoprotein E (apoE)-deficient mice and reduced serum concentrations of IL-6 and IL-1beta without affecting body weights, serum lipid profiles or IL-10 levels.	tamibarotene	27-31	interleukin 1 beta	Mus musculus	218-226
16441241-10	2006	The effects of IL-1beta were abolished by aminoguanidine, a selective inhibitor of inducible NOS (nitric oxide synthase), or by rofecoxib, a specific inhibitor of COX-2 (cyclo-oxygenase 2).	pimagedine	42-56	interleukin 1 beta	Mus musculus	15-23
16441241-10	2006	The effects of IL-1beta were abolished by aminoguanidine, a selective inhibitor of inducible NOS (nitric oxide synthase), or by rofecoxib, a specific inhibitor of COX-2 (cyclo-oxygenase 2).	rofecoxib	128-137	interleukin 1 beta	Mus musculus	15-23
16299037-9	2006	DHNA significantly attenuated the enhanced expression of MAdCAM-1, the increased beta7 positive cell number, and the increased mRNA levels of IL-1beta, IL-6, and TNF-alpha in DSS treated colon.	1,4-dihydroxy-2-naphthoic acid	0-4	interleukin 1 beta	Mus musculus	142-150
16299037-9	2006	DHNA significantly attenuated the enhanced expression of MAdCAM-1, the increased beta7 positive cell number, and the increased mRNA levels of IL-1beta, IL-6, and TNF-alpha in DSS treated colon.	dss	175-178	interleukin 1 beta	Mus musculus	142-150
16501055-6	2006	Furthermore, the absence of a functional PPAR-alpha gene enhanced the staining (immunohistochemistry) for FAS ligand in the paw and in the lung and the expression of tumor necrosis factor alpha and interleukin-1beta in the lungs of carrageenan-treated mice.	Carrageenan	232-243	interleukin 1 beta	Mus musculus	198-215
16458386-7	2006	Furthermore, we found that uptake of CpGs in LSECs results in the activation of transcription factor NF-kappaB and secretion of IL-1beta and IL-6.	CPG-oligonucleotide	37-41	interleukin 1 beta	Mus musculus	128-136
16647840-3	2006	Compared with 5 microg/mL, tilmicosin and tylosin concentrations of 10 microg/mL and 20 microg/mL significantly decreased the production of 6-keto-prostaglandin F(1alpha) (6-keto-PGF(1alpha)), PGE(2), NO, tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6, and increased IL-10 production.	tilmicosin	27-37	interleukin 1 beta	Mus musculus	247-269
16647840-3	2006	Compared with 5 microg/mL, tilmicosin and tylosin concentrations of 10 microg/mL and 20 microg/mL significantly decreased the production of 6-keto-prostaglandin F(1alpha) (6-keto-PGF(1alpha)), PGE(2), NO, tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6, and increased IL-10 production.	Tylosin	42-49	interleukin 1 beta	Mus musculus	247-269
16647840-3	2006	Compared with 5 microg/mL, tilmicosin and tylosin concentrations of 10 microg/mL and 20 microg/mL significantly decreased the production of 6-keto-prostaglandin F(1alpha) (6-keto-PGF(1alpha)), PGE(2), NO, tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6, and increased IL-10 production.	6-keto-prostaglandin f	140-162	interleukin 1 beta	Mus musculus	247-269
16647840-3	2006	Compared with 5 microg/mL, tilmicosin and tylosin concentrations of 10 microg/mL and 20 microg/mL significantly decreased the production of 6-keto-prostaglandin F(1alpha) (6-keto-PGF(1alpha)), PGE(2), NO, tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6, and increased IL-10 production.	6-keto-pgf	172-182	interleukin 1 beta	Mus musculus	247-269
16364651-5	2006	We found that 2-AG decreased BBB permeability and inhibited the acute expression of the main proinflammatory cytokines: TNF-alpha, IL-1beta and IL-6.	glyceryl 2-arachidonate	14-18	interleukin 1 beta	Mus musculus	131-139
16214328-8	2006	Moreover, NAC supplementation in PM mice restored the expression of IkappaBalpha, IL-1beta and TNF-alpha and infiltration of neutrophils to levels observed in control animals.	Acetylcysteine	10-13	interleukin 1 beta	Mus musculus	82-90
16504308-3	2006	Both human and mouse IL-1beta genes carry multiple HIF-1-binding sites in their promoter regions and are up-regulated by hypoxia and CoCl2 in human and mouse astrocytes in parallel with up-regulation of HIF-1alpha mRNA and protein.	cobaltous chloride	133-138	interleukin 1 beta	Mus musculus	21-29
16504308-5	2006	Mouse astrocytes with Hif1alpha+/- genotype demonstrated attenuated up-regulation of both HIF-1alpha and IL-1beta by hypoxia and CoCl2.	cobaltous chloride	129-134	interleukin 1 beta	Mus musculus	105-113
16373423-5	2006	Moreover, female mice treated with melatonin showed a diminution of titers of total serum IgG, IgM, and anti-double-stranded DNA and anti-CII autoantibodies; a decrease in proinflammatory cytokines (IL-2, IL-6, interferon-gamma, TNF-alpha, and IL-1beta), an increase in antiinflammatory cytokines (IL-10), and a decrease in nitrite/nitrate.	Melatonin	35-44	interleukin 1 beta	Mus musculus	244-252
16457781-7	2006	Furthermore, rengyolone suppressed the expression of ICE protein in IL-1beta-treated D10S cells.	Rengyolone	13-23	interleukin 1 beta	Mus musculus	68-76
16649552-8	2006	Significant post-inoculation elevations of interleukin (IL)-1beta, IL-6, and IL-10 were noted in untreated controls over 24 h. Telithromycin attenuated these increases and the suppression of both IL-6 and IL-10 release was observed to be dose dependent.	telithromycin	127-140	interleukin 1 beta	Mus musculus	43-65
16352705-4	2006	Tipifarnib also inhibited LPS-induced secretion of MMP-9, IL-6, MCP-1, and IL-1beta in THP-1 cells.	tipifarnib	0-10	interleukin 1 beta	Mus musculus	75-83
16352705-6	2006	Similar results were obtained in vivo in a murine model of LPS-induced inflammation, where pretreatment with tipifarnib resulted in significant inhibition of TNF-alpha, IL-6, MCP-1, IL-1beta, and MIP-1alpha production.	tipifarnib	109-119	interleukin 1 beta	Mus musculus	182-190
16539667-10	2006	Moreover, in cultured cortical primary microglia, rosiglitazone attenuated inflammatory responses by decreasing lipopolysaccharide-induced release of tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6.	Rosiglitazone	50-63	interleukin 1 beta	Mus musculus	179-201
16520227-4	2006	Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by fluid accumulation in the pleural cavity which contained a large number of neutrophils (PMNs) as well as an infiltration of PMNs in lung tissues and subsequent lipid peroxidation (as determined by thiobarbituric acid-reactant substance measurement) and increased production of tumor necrosis factor-alpha, (TNF-alpha) and interleukin-1beta (IL-1 beta).	Carrageenan	13-24	interleukin 1 beta	Mus musculus	436-453
16269622-5	2006	Lipopolysaccharide (LPS)-mediated activation of TAMs resulted in defective expression of several proinflammatory cytokines (eg, IL-1beta, IL-6, TNF-alpha) and chemokines (eg, CCL3), as opposed to a strong up-regulation of immunosuppressive cytokines (IL-10, TGFbeta) and IFN-inducible chemokines (CCL5, CXCL9, CXCL10, CXCL16).	tams	48-52	interleukin 1 beta	Mus musculus	128-136
16423834-6	2006	By incubation with mK13, but not with mK1, mK9, or mK22, the 35-kDa pro-IL-1beta was cleaved into two major products with molecular masses of 17.5 and 22 kDa, and production was inhibited by phenylmethylsulfonyl fluoride, a serine protease inhibitor, but not by IL-1beta-converting enzyme inhibitors.	Phenylmethylsulfonyl Fluoride	191-220	interleukin 1 beta	Mus musculus	72-80
16517734-0	2006	Modification of MyD88 mRNA splicing and inhibition of IL-1beta signaling in cell culture and in mice with a 2"-O-methoxyethyl-modified oligonucleotide.	2"-o-methoxyethyl-modified oligonucleotide	108-150	interleukin 1 beta	Mus musculus	54-62
16520227-4	2006	Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by fluid accumulation in the pleural cavity which contained a large number of neutrophils (PMNs) as well as an infiltration of PMNs in lung tissues and subsequent lipid peroxidation (as determined by thiobarbituric acid-reactant substance measurement) and increased production of tumor necrosis factor-alpha, (TNF-alpha) and interleukin-1beta (IL-1 beta).	Carrageenan	13-24	interleukin 1 beta	Mus musculus	455-464
16546100-4	2006	NALP3 was essential for the ATP-driven activation of caspase-1 in lipopolysaccharide-stimulated macrophages and for the efficient secretion of the caspase-1-dependent cytokines IL-1alpha, IL-1beta, and IL-18.	Adenosine Triphosphate	28-31	interleukin 1 beta	Mus musculus	188-196
16546100-5	2006	IL-1beta has been shown to play a key role in contact hypersensitivity; we show that ASC- and NALP3-deficient mice also demonstrate an impaired contact hypersensitivity response to the hapten trinitrophenylchloride.	trinitrophenylchloride	192-214	interleukin 1 beta	Mus musculus	0-8
16557482-2	2006	Ginsenoside Rh1 potently suppressed the TPA- and oxazolone-induced swellings as well as mRNA expression levels of cyclooxygenase-2, IL-1beta and TNF-alpha, although these were only weakly inhibited by ginsenoside Re.	ginsenoside Rh1	0-15	interleukin 1 beta	Mus musculus	132-140
16487508-0	2006	Involvement of Ca(2+)-induced Ca2+ releasing system in interleukin-1beta-associated adenosine release.	Adenosine	84-93	interleukin 1 beta	Mus musculus	55-72
16487508-4	2006	Lower concentration of IL-1beta increased both adenosine releases, whereas higher concentration did not affect their releases.	Adenosine	47-56	interleukin 1 beta	Mus musculus	23-31
16487508-5	2006	The stimulatory effect of IL-1beta on basal adenosine release was reduced by removal of extracellular Ca2+ and IP3 receptor inhibitor, while the stimulatory effect of IL-1beta on K(+)-stimulated adenosine release was reduced by ryanodine receptor inhibitor.	Adenosine	44-53	interleukin 1 beta	Mus musculus	26-34
16487508-5	2006	The stimulatory effect of IL-1beta on basal adenosine release was reduced by removal of extracellular Ca2+ and IP3 receptor inhibitor, while the stimulatory effect of IL-1beta on K(+)-stimulated adenosine release was reduced by ryanodine receptor inhibitor.	Adenosine	195-204	interleukin 1 beta	Mus musculus	167-175
16487508-6	2006	These results suggest that the potent effect of IL-1beta upon adenosine release might contribute to the neuroprotective action of IL-1beta, whereas IL-1beta-induced neurodegeneration might be due to the overload response of Ca2+ mobilization and the inactivation of adenosine exocytosis.	Adenosine	62-71	interleukin 1 beta	Mus musculus	48-56
16487508-6	2006	These results suggest that the potent effect of IL-1beta upon adenosine release might contribute to the neuroprotective action of IL-1beta, whereas IL-1beta-induced neurodegeneration might be due to the overload response of Ca2+ mobilization and the inactivation of adenosine exocytosis.	Adenosine	62-71	interleukin 1 beta	Mus musculus	130-138
16487508-6	2006	These results suggest that the potent effect of IL-1beta upon adenosine release might contribute to the neuroprotective action of IL-1beta, whereas IL-1beta-induced neurodegeneration might be due to the overload response of Ca2+ mobilization and the inactivation of adenosine exocytosis.	Adenosine	62-71	interleukin 1 beta	Mus musculus	130-138
16487508-6	2006	These results suggest that the potent effect of IL-1beta upon adenosine release might contribute to the neuroprotective action of IL-1beta, whereas IL-1beta-induced neurodegeneration might be due to the overload response of Ca2+ mobilization and the inactivation of adenosine exocytosis.	Adenosine	266-275	interleukin 1 beta	Mus musculus	48-56
16009389-4	2006	and treated 8 h later with DON po., the minimum DON doses for inducing IL-1alpha, IL-1beta, IL-6 and TNF-alpha serum proteins and splenic mRNAs were significantly lower than the DON doses required for vehicle-primed mice.	deoxynivalenol	48-51	interleukin 1 beta	Mus musculus	82-90
16433833-6	2006	RESULTS: Subcutaneous injection of turpentine induced mice systemic inflammation, as indicated by significant increase in serum IL-1beta levels, and IL-1alpha, IL-1beta and IL-1ra in spleen homogenates.	Turpentine	35-45	interleukin 1 beta	Mus musculus	128-136
16174862-5	2006	TSA treatment of cells stably transfected with an iNOS promoter-luciferase construct inhibited IL-1beta induction of endogenous nitric oxide and iNOS protein production and iNOS promoter-luciferase activity.	trichostatin A	0-3	interleukin 1 beta	Mus musculus	95-103
16174862-5	2006	TSA treatment of cells stably transfected with an iNOS promoter-luciferase construct inhibited IL-1beta induction of endogenous nitric oxide and iNOS protein production and iNOS promoter-luciferase activity.	Nitric Oxide	128-140	interleukin 1 beta	Mus musculus	95-103
16174862-6	2006	Chromatin immunoprecipitation assays revealed that, under basal conditions, acetylated histone H4 associated with the region -978 to -710 of the iNOS promoter, a region rich in gene control elements and that IL-1beta significantly increased this binding, which was further accentuated by cotreatment with TSA.	trichostatin A	305-308	interleukin 1 beta	Mus musculus	208-216
16174862-7	2006	Blockade of the phosphoinositide 3-kinase pathway with LY-294002 or the p70s6-kinase pathway with rapamycin in the presence of TSA and IL-1beta inhibited 389Thr phosphorylation of p70s6 kinase, promoted binding of acetylated histone H4 to the iNOS promoter, and further suppressed iNOS protein expression and iNOS promoter activity.	Sirolimus	98-107	interleukin 1 beta	Mus musculus	135-143
16174862-8	2006	Thus TSA diminishes IL-1beta-induced iNOS transcription through phosphoinositide 3-kinase- and p70s6 kinase-dependent pathways that increase site-specific histone H4 acetylation at the -978 to -710 region of the iNOS promoter.	trichostatin A	5-8	interleukin 1 beta	Mus musculus	20-28
16433833-6	2006	RESULTS: Subcutaneous injection of turpentine induced mice systemic inflammation, as indicated by significant increase in serum IL-1beta levels, and IL-1alpha, IL-1beta and IL-1ra in spleen homogenates.	Turpentine	35-45	interleukin 1 beta	Mus musculus	160-168
16433833-7	2006	The levels of IL-1alpha, IL-1beta and IL-1ra were significantly induced in testicular homogenates of adult mice following subcutaneous injection of turpentine.	Turpentine	148-158	interleukin 1 beta	Mus musculus	25-33
16433833-9	2006	However, significant induction of testicular IL-1beta was detected only after 3-10 days of turpentine injection, and for testicular IL-1ra levels was detected after 3 hr to 6 days of turpentine injection, and after 10 days the levels were similar to the control.	Turpentine	91-101	interleukin 1 beta	Mus musculus	45-53
16404705-5	2006	A single topical application of TPA to ears of CD-1 mice induced a time- and dose-dependent increase in edema as well as formation of proinflammatory cytokine proteins interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in mouse ears.	Tetradecanoylphorbol Acetate	32-35	interleukin 1 beta	Mus musculus	187-195
16374455-4	2006	Moreover, NYT dose-dependently increased the surface expression of major histocompatibility complex (MHC) class II (MHC II), CD40, CD54, CD80, and CD86 by murine bone marrow-derived DCs and triggered their robust production of IL-1beta, IL-6, IL-12, tumor necrosis factor alpha, and macrophage inflammatory protein-1alpha.	Nystatin	10-13	interleukin 1 beta	Mus musculus	227-235
16303184-4	2006	The studies demonstrated that 9-cis-RA inhibited the production of nitric oxide (NO) as well as the pro-inflammatory cytokines TNF-alpha, IL-1beta and IL-12 p40 by LPS-stimulated microglia.	Alitretinoin	30-38	interleukin 1 beta	Mus musculus	138-146
16404705-5	2006	A single topical application of TPA to ears of CD-1 mice induced a time- and dose-dependent increase in edema as well as formation of proinflammatory cytokine proteins interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) in mouse ears.	Tetradecanoylphorbol Acetate	32-35	interleukin 1 beta	Mus musculus	168-185
16182479-3	2006	The total crude extract (100 microg/ml) prepared with 80% methanol (MeOH extract) and its fractions (100 microg/ml) obtained by solvent partition with hexane and ethyl acetate (EtOAc) significantly blocked the production of interleukin (IL)-1 beta, IL-6 and the tumor necrosis factor (TNF)-alpha from RAW264.7 cells stimulated by lipopolysaccharide (LPS) up to 20-70%.	Methanol	68-72	interleukin 1 beta	Mus musculus	224-247
16182479-3	2006	The total crude extract (100 microg/ml) prepared with 80% methanol (MeOH extract) and its fractions (100 microg/ml) obtained by solvent partition with hexane and ethyl acetate (EtOAc) significantly blocked the production of interleukin (IL)-1 beta, IL-6 and the tumor necrosis factor (TNF)-alpha from RAW264.7 cells stimulated by lipopolysaccharide (LPS) up to 20-70%.	ethyl acetate	162-175	interleukin 1 beta	Mus musculus	224-247
16182479-3	2006	The total crude extract (100 microg/ml) prepared with 80% methanol (MeOH extract) and its fractions (100 microg/ml) obtained by solvent partition with hexane and ethyl acetate (EtOAc) significantly blocked the production of interleukin (IL)-1 beta, IL-6 and the tumor necrosis factor (TNF)-alpha from RAW264.7 cells stimulated by lipopolysaccharide (LPS) up to 20-70%.	ethyl acetate	177-182	interleukin 1 beta	Mus musculus	224-247
16297883-8	2006	Dioscorin also stimulated multiple signaling molecules (NF-kappaB, ERK, JNK, and p38) and induced the expression of cytokines (TNF-alpha, IL-1beta, and IL-6) in murine RAW 264.7 macrophages.	dioscorin	0-9	interleukin 1 beta	Mus musculus	138-146
16091933-0	2006	Tripeptide tyroserleutide enhances the antitumor effects of macrophages and stimulates macrophage secretion of IL-1beta, TNF-alpha, and NO in vitro.	tripeptide tyroserleutide	0-25	interleukin 1 beta	Mus musculus	111-119
16254210-5	2006	We quantified 18 different serum cytokines and found a significant increase of tumor necrosis factor alpha, interleukin 1beta, and keratinocyte-derived chemokine in nicotine-treated mice.	Nicotine	165-173	interleukin 1 beta	Mus musculus	108-125
17201208-0	2006	Role of interleukin-1beta and tumour necrosis factor-alpha on hydroxyapatite-induced phagocytosis by murine macrophages (RAW264.7 cells).	Durapatite	62-76	interleukin 1 beta	Mus musculus	8-58
16091933-7	2006	These data suggest that YSL activates the monocyte-macrophage system, which enhances Mphi antitumor effects against BEL-7402 and B16-F10 cells and stimulates the secretion by Mphi of cytotoxic effectors such as IL-1beta, TNF-alpha, and NO.	H-Tyr-Ser-Leu-OH	24-27	interleukin 1 beta	Mus musculus	211-219
16328023-2	2006	In the course of our study, we examined the effects of triptolide on stimulated murine macrophages and demonstrated that triptolide inhibited superoxide anion production, NO production, and the expression of iNOS mRNA and the mRNA of some key inflammation-related cytokines, namely TNF-alpha, IL-1beta, IL-6 and IFN-gamma.	triptolide	121-131	interleukin 1 beta	Mus musculus	293-301
16342327-5	2006	However, the production of proinflammatory cytokines, such as TNF-alpha, IL-1beta, IL-6, IFN-gamma, IL-12, and IL-18, was markedly down-regulated in ginsan-treated mice compared with those of control-infected mice.	ginsan	149-155	interleukin 1 beta	Mus musculus	73-81
16300639-5	2006	SP600125, a JNK inhibitor, inhibited, in a concentration-dependent manner, IL-1beta-induced activation of JNK with a maximum of 87% at 10(-4) m. In vivo, IL-1beta stimulated JNK and the expression of the inducible isoform of nitric oxide synthase (iNOS).	pyrazolanthrone	0-8	interleukin 1 beta	Mus musculus	75-83
16338964-0	2006	Src activation of NF-kappaB augments IL-1beta-induced nitric oxide production in mesangial cells.	Nitric Oxide	54-66	interleukin 1 beta	Mus musculus	37-45
16338964-5	2006	The SFK antagonist 4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazolo(3,4-d)pyrimidine (PP2) dramatically inhibited IL-1beta-mediated induction of endogenous NO production as measured by the Griess reaction, as well as the induction of NF-kappaB p50/p65 DNA-binding activity in gel shift assays and the activity of an NF-kappaB-responsive promoter-reporter construct transiently transfected into the cells.	AG 1879	19-83	interleukin 1 beta	Mus musculus	113-121
16338964-9	2006	Thus, SFK play a key role in IL-1beta-induced NO production in mesangial cells and do so via tyrosine phosphorylation of IkappaBalpha and consequent NF-kappaB activation.	Tyrosine	93-101	interleukin 1 beta	Mus musculus	29-37
16300639-5	2006	SP600125, a JNK inhibitor, inhibited, in a concentration-dependent manner, IL-1beta-induced activation of JNK with a maximum of 87% at 10(-4) m. In vivo, IL-1beta stimulated JNK and the expression of the inducible isoform of nitric oxide synthase (iNOS).	pyrazolanthrone	0-8	interleukin 1 beta	Mus musculus	154-162
16300639-6	2006	IL-1beta inhibited high KCl and adrenergic agonist induced protein secretion by 85% and 66%, respectively.	Potassium Chloride	24-27	interleukin 1 beta	Mus musculus	0-8
16300639-7	2006	SP600125 alleviated the inhibitory effect of IL-1beta on KCl- and agonist-induced protein secretion by 79% and 47%, respectively, and completely blocked the expression of iNOS.	pyrazolanthrone	0-8	interleukin 1 beta	Mus musculus	45-53
16300639-7	2006	SP600125 alleviated the inhibitory effect of IL-1beta on KCl- and agonist-induced protein secretion by 79% and 47%, respectively, and completely blocked the expression of iNOS.	Potassium Chloride	57-60	interleukin 1 beta	Mus musculus	45-53
16260063-2	2005	Results showed that the immunoreactivities of IL-1beta, IL-6, TGF-beta1, fractalkine and MCP-1 were upregulated in the DMV at 14 days and the upregulation persisted at least until 28 days following right vagotomy.	(2R,3R)-2,3-dihydroxy-3-methylpentanoic acid	119-122	interleukin 1 beta	Mus musculus	46-54
16393471-12	2006	Moreover, ethyl acetate fractions significantly blocked the expression of IL-1beta from the RAW264.7 cells stimulated by LPS.	ethyl acetate	10-23	interleukin 1 beta	Mus musculus	74-82
16298020-4	2006	15,16-Dihydotanshinoe I suppressed the expression of not only inducible nitric oxide synthase but also of interleukin-1beta, tumor necrosis factor-alpha, and of TNF-alpha converting enzyme.	15,16-dihydotanshinoe i	0-23	interleukin 1 beta	Mus musculus	106-152
16391493-6	2006	RESULTS: Berberine dose-dependently inhibited IL-8 mRNA and MCP-1 mRNA expression of the cells and protein levels in the media stimulated with IL-1beta or TNF-alpha.	Berberine	9-18	interleukin 1 beta	Mus musculus	143-151
16005558-5	2005	Incubation with sodium acetate for 24 h increased the levels of IL-1beta, IL-8, and TNF-alpha protein and mRNAs (IL-6 was detected but its mRNA was not).	Sodium Acetate	16-30	interleukin 1 beta	Mus musculus	64-72
16150911-6	2005	In contrast, local inflammation induced by turpentine did not decrease liver D1 and D3 activity but increased markedly D3 activity in the muscle/subcutis sample containing the abscess, associated with strongly increased IL-1beta and IL-6 mRNA expression.	Turpentine	43-53	interleukin 1 beta	Mus musculus	220-228
16299325-3	2005	Noncapsulated mannose-containing O3 serotypes (K50/n and K55/n), which react efficiently with SP-D in vitro, triggered high levels of interleukin-1beta (IL-1beta) and IL-6 production.	Mannose	14-21	interleukin 1 beta	Mus musculus	134-151
16299325-3	2005	Noncapsulated mannose-containing O3 serotypes (K50/n and K55/n), which react efficiently with SP-D in vitro, triggered high levels of interleukin-1beta (IL-1beta) and IL-6 production.	Mannose	14-21	interleukin 1 beta	Mus musculus	153-161
16273230-5	2005	RT-PCR analysis showed that CLA up-regulated the expression of TNF-alpha, IL-1beta and IFN-gamma genes in WEHI-3B JCS cells, which had previously been shown to play an important role in triggering the differentiation of myeloid leukemia cells.	Linoleic Acids, Conjugated	28-31	interleukin 1 beta	Mus musculus	74-82
16154758-9	2005	The most potent stimulant properties disclosed PP(Phe)(2)Arg(2) derivative for which the highest values of IL-1beta, IL-6 and NO(2)(-) were noticed.	Phenylalanine	50-53	interleukin 1 beta	Mus musculus	107-115
16301672-0	2005	Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor.	Chlorides	22-30	interleukin 1 beta	Mus musculus	63-71
16301672-3	2005	In Bac1 murine macrophages, substitution of extracellular Cl- with gluconate produced a 10-fold increase in the rate and extent of ATP-induced IL-1beta processing and secretion, while reducing the EC50 for ATP by 5-fold.	gluconic acid	67-76	interleukin 1 beta	Mus musculus	143-151
16301672-3	2005	In Bac1 murine macrophages, substitution of extracellular Cl- with gluconate produced a 10-fold increase in the rate and extent of ATP-induced IL-1beta processing and secretion, while reducing the EC50 for ATP by 5-fold.	Adenosine Triphosphate	131-134	interleukin 1 beta	Mus musculus	143-151
16301672-4	2005	Replacement of Cl- with gluconate also increased the potency of ATP as an inducer of mature IL-1beta secretion in primary mouse bone marrow-derived macrophages and in THP-1 human monocytes/macrophages.	gluconic acid	24-33	interleukin 1 beta	Mus musculus	92-100
16301672-4	2005	Replacement of Cl- with gluconate also increased the potency of ATP as an inducer of mature IL-1beta secretion in primary mouse bone marrow-derived macrophages and in THP-1 human monocytes/macrophages.	Adenosine Triphosphate	64-67	interleukin 1 beta	Mus musculus	92-100
16301672-6	2005	This cytolysis was repressed by the cytoprotectant glycine, permitting dissociation of P2X7R-regulated secretion of mature IL-1beta from the lytic release of pro-IL-1beta.	Glycine	51-58	interleukin 1 beta	Mus musculus	123-131
16301672-6	2005	This cytolysis was repressed by the cytoprotectant glycine, permitting dissociation of P2X7R-regulated secretion of mature IL-1beta from the lytic release of pro-IL-1beta.	Glycine	51-58	interleukin 1 beta	Mus musculus	162-170
16154758-9	2005	The most potent stimulant properties disclosed PP(Phe)(2)Arg(2) derivative for which the highest values of IL-1beta, IL-6 and NO(2)(-) were noticed.	Arginine	57-60	interleukin 1 beta	Mus musculus	107-115
16317386-4	2005	An increase of immunoreactivity to poly-ADP-ribose, TNF-alpha, and IL-1 beta, as well as a significant loss of body weight and mortality was observed in the lung of bleomycin-treated PPAR-alpha WT mice.	Bleomycin	165-174	interleukin 1 beta	Mus musculus	67-76
16005069-10	2005	In BV-2 cells and primary astrocytes, the expression of TNFalpha and IL-1beta analyzed by real-time polymerase chain reaction was downregulated at 6 or 24 h. In all cell types tested the FB1 treatment caused accumulation of free sphinganine and decrease in free sphingosine levels at selected time points.	safingol	229-240	interleukin 1 beta	Mus musculus	69-77
16005069-10	2005	In BV-2 cells and primary astrocytes, the expression of TNFalpha and IL-1beta analyzed by real-time polymerase chain reaction was downregulated at 6 or 24 h. In all cell types tested the FB1 treatment caused accumulation of free sphinganine and decrease in free sphingosine levels at selected time points.	Sphingosine	262-273	interleukin 1 beta	Mus musculus	69-77
15942272-6	2005	Olopatadine significantly inhibited the ear swelling and the increased production of IL-4, IL-1beta, IL-6, GM-CSF and NGF in the lesioned ear.	Olopatadine Hydrochloride	0-11	interleukin 1 beta	Mus musculus	91-99
16202978-0	2005	Interleukin-1beta targets interleukin-6 in progressing dextran sulfate sodium-induced experimental colitis.	Dextran Sulfate	55-77	interleukin 1 beta	Mus musculus	0-17
16202978-3	2005	The purpose of the present study was to clarify which pro-inflammatory mediators are targeted by IL-1beta in mice with DSS-induced colitis.	Dextran Sulfate	119-122	interleukin 1 beta	Mus musculus	97-105
16202978-5	2005	Further, the expressions of mRNA and protein for IL-1beta were increased in colonic mucosa and pMphi from mice that received drinking water containing 5% DSS for 7 days (P &lt; 0.01, each).	Water	134-139	interleukin 1 beta	Mus musculus	49-57
16202978-4	2005	First, we found that DSS markedly induced IL-1beta production in both dose- and time-dependent manners (P &lt; 0.05 and P &lt; 0.01, respectively) in murine peritoneal macrophages (pMphi), while that of tumor necrosis factor-alpha was insignificant.	Dextran Sulfate	21-24	interleukin 1 beta	Mus musculus	42-50
16202978-5	2005	Further, the expressions of mRNA and protein for IL-1beta were increased in colonic mucosa and pMphi from mice that received drinking water containing 5% DSS for 7 days (P &lt; 0.01, each).	Dextran Sulfate	154-157	interleukin 1 beta	Mus musculus	49-57
16202978-10	2005	attenuated DSS-induced body weight reduction and shortening of the colorectum (P &lt; 0.05, each), and abrogated the expressions of IL-1beta and IL-6 mRNA in colonic mucosa (P &lt; 0.01, each).	Dextran Sulfate	11-14	interleukin 1 beta	Mus musculus	132-140
16275942-11	2005	Pretreatment with xylitol inhibited LPS-induced TNF-alpha and IL-1beta gene expression and protein synthesis.	Xylitol	18-25	interleukin 1 beta	Mus musculus	62-70
16202978-11	2005	Our results evidently support the previous findings that IL-1beta is involved in the development of DSS-induced experimental colitis in mice, and strongly suggest that IL-1beta targets itself and IL-6 for progressing colonic inflammation.	Dextran Sulfate	100-103	interleukin 1 beta	Mus musculus	57-65
16202978-11	2005	Our results evidently support the previous findings that IL-1beta is involved in the development of DSS-induced experimental colitis in mice, and strongly suggest that IL-1beta targets itself and IL-6 for progressing colonic inflammation.	Dextran Sulfate	100-103	interleukin 1 beta	Mus musculus	168-176
16279805-6	2005	Intravenous administration of (R)-(+)-5n at doses of 0.1 mg/kg or more suppressed the production of NO and various cytokines [TNF-alpha, IL-6 and IL-1beta] in the mouse endotoxin shock model.	(r)-(+)-5n	30-40	interleukin 1 beta	Mus musculus	146-154
16239969-9	2005	After day 4, clodronate liposomes, which kill macrophages, reduced IL-1beta-induced angiogenesis and partially inhibited VEGF-induced angiogenesis.	Clodronic Acid	13-23	interleukin 1 beta	Mus musculus	67-75
16098614-6	2005	Treatment of T-cells with GW0742 either in vivo or in vitro did not reduce IFNgamma production; however GW0742 reduced astroglial and microglial inflammatory activation and IL-1beta levels in EAE brain.	GW0742	104-110	interleukin 1 beta	Mus musculus	173-181
16204946-3	2005	In addition, chiisanoside significantly reduced the release of inflammatory cytokines like TNF-alpha and IL-1beta.	chiisanoside	13-25	interleukin 1 beta	Mus musculus	105-113
16211301-5	2005	In this study, to identify the MSSP-dependent Fas-induced apoptosis pathway, primary fibroblasts from MSSP (+/+) and MSSP (-/-) cells were treated with the combination of interleukin 1-beta and interferon-gamma and expression of the Fas gene was examined.	ammonium ferrous sulfate	46-49	interleukin 1 beta	Mus musculus	171-189
16230411-9	2005	Administration of celecoxib or NS-398 attenuated tissue levels of prostaglandin E2 and vascular endothelial growth factor induced by PDT in treated tumors and also decreased the expression of proinflammatory mediators interleukin-1beta and tumor necrosis factor-alpha.	Celecoxib	18-27	interleukin 1 beta	Mus musculus	218-267
16230411-9	2005	Administration of celecoxib or NS-398 attenuated tissue levels of prostaglandin E2 and vascular endothelial growth factor induced by PDT in treated tumors and also decreased the expression of proinflammatory mediators interleukin-1beta and tumor necrosis factor-alpha.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	31-37	interleukin 1 beta	Mus musculus	218-267
16200597-12	2005	The levels of PGE2, IL-1beta, and TNFalpha were also significantly reduced by SnPP treatment, which did not modify COX-2 protein expression.	S-Nitroso-N-propionyl-D,L-penicillamine	78-82	interleukin 1 beta	Mus musculus	20-28
16204946-6	2005	Taken together, our data indicate that the anti-inflammatory properties of chiisanoside might be the result from the inhibition of iNOS, COX-2, TNF-alpha and IL-1beta expression through the down-regulation of NF-kappaB binding activity.	chiisanoside	75-87	interleukin 1 beta	Mus musculus	158-166
16245181-0	2005	Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1beta and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells.	surfactin peptide	0-11	interleukin 1 beta	Mus musculus	69-86
16084489-7	2005	Treatment of mice with acetylsalicylic acid or indomethacin at doses effective to cause near-complete inhibition of PGE(2) and PGD(2) biosynthesis in heart ex vivo resulted in enhanced expression of IL-1beta 24h after endotoxin administration.	Aspirin	23-43	interleukin 1 beta	Mus musculus	199-207
16245181-3	2005	However, surfactin C at 50 microg ml(-1 )inhibited the LPS-induced increase in the transcription of IL-1beta and iNOS and nitric oxide (NO) production in a dose-dependent manner.	surfactin peptide	9-20	interleukin 1 beta	Mus musculus	100-108
16046471-7	2005	Dominant negative IKKbeta or pharmacological IKK inhibition blocked S468 phosphorylation after TNF-alpha or IL-1beta, whereas dominant negative IKKalpha or inhibitors of MEK, p38, JNK, PI-3 kinase, or GSK-3 had no effect.	Pirenoxine sodium	68-72	interleukin 1 beta	Mus musculus	108-116
16205319-6	2005	The levels of inducible nitric oxide synthase in the liver, nitrite, and inflammatory cytokines like interleukin 1beta and tumor necrosis factor-alpha in the serum increased in WBH-treated mice.	wbh	177-180	interleukin 1 beta	Mus musculus	101-150
16210060-6	2005	Prevention of IL-1 signaling through deletion of the IL-1 receptor type I or administration of neutralizing antibodies to both IL-1beta and IL-1alpha abrogated the development of TDI-induced asthma.	Toluene 2,4-Diisocyanate	179-182	interleukin 1 beta	Mus musculus	127-135
16084489-7	2005	Treatment of mice with acetylsalicylic acid or indomethacin at doses effective to cause near-complete inhibition of PGE(2) and PGD(2) biosynthesis in heart ex vivo resulted in enhanced expression of IL-1beta 24h after endotoxin administration.	Indomethacin	47-59	interleukin 1 beta	Mus musculus	199-207
16084489-7	2005	Treatment of mice with acetylsalicylic acid or indomethacin at doses effective to cause near-complete inhibition of PGE(2) and PGD(2) biosynthesis in heart ex vivo resulted in enhanced expression of IL-1beta 24h after endotoxin administration.	Prostaglandins E	116-119	interleukin 1 beta	Mus musculus	199-207
16084489-7	2005	Treatment of mice with acetylsalicylic acid or indomethacin at doses effective to cause near-complete inhibition of PGE(2) and PGD(2) biosynthesis in heart ex vivo resulted in enhanced expression of IL-1beta 24h after endotoxin administration.	Prostaglandin D2	127-132	interleukin 1 beta	Mus musculus	199-207
16109400-1	2005	Pituicytes, the astrocytic glial cells of the neural lobe, are known to secrete interleukin-6 and nitric oxide upon stimulation with various inflammatory mediators, i.e. interleukin-1beta.	Nitric Oxide	98-110	interleukin 1 beta	Mus musculus	170-187
16109400-9	2005	Co-stimulation with interferon-gamma and interleukin-1beta induced a significant nitric oxide release.	Nitric Oxide	81-93	interleukin 1 beta	Mus musculus	41-58
16109400-3	2005	The aim of the present study was to investigate the effect of nitric oxide on interleukin-1beta induced interleukin-6 secretion.	Nitric Oxide	62-74	interleukin 1 beta	Mus musculus	78-95
15935613-12	2005	RU486 and nadolol treatment also tended to decrease IL-10, IFN-gamma, TNFalpha (nadolol only), and IL-1beta (RU486 only) in both exercise and control mice, suggesting that stress hormones may be necessary during infection for optimal responsiveness.	Nadolol	10-17	interleukin 1 beta	Mus musculus	99-107
16142712-7	2005	Neutrophil influx and local induction of IL-1beta in subcutaneous air pouches were suppressed 6 hours after injection of MSU crystals in TLR-2-/- and TLR-4-/- mice and were attenuated in MyD88-/- mice.	Uric Acid	121-124	interleukin 1 beta	Mus musculus	41-49
16101294-0	2005	IL-1beta epitope mapping using site-directed mutagenesis and hydrogen-deuterium exchange mass spectrometry analysis.	Hydrogen	61-69	interleukin 1 beta	Mus musculus	0-8
16116312-6	2005	RESULTS: Intracolonic administration of oxazolone increased myeloperoxidase activity, damage score, and interleukin (IL)-4, IL-10, tumor necrosis factor alpha, and IL-1beta mRNA expression but lowered interferon-gamma mRNA expression, indicating colonic inflammation of a TH2 profile.	Oxazolone	40-49	interleukin 1 beta	Mus musculus	164-172
16023781-1	2005	In rodent islets, exposure to interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma) induces expression of inducible nitric oxide synthase (iNOS) and subsequent nitric oxide (NO) formation, which may inhibit islet function.	Nitric Oxide	124-136	interleukin 1 beta	Mus musculus	30-47
16023781-1	2005	In rodent islets, exposure to interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma) induces expression of inducible nitric oxide synthase (iNOS) and subsequent nitric oxide (NO) formation, which may inhibit islet function.	Nitric Oxide	124-136	interleukin 1 beta	Mus musculus	49-57
16023606-4	2005	Furthermore, Fumigaclavine C, given both in vivo and in vitro, showed a marked inhibition on the expression of several inflammatory cytokines, including IL-1beta, IL-2, IL-12alpha, IFN-gamma, TNF-alpha as well as MMP-9 in sacral lymph node cells, colonic patch lymphocytes and colitis tissues from the TNBS colitis mice.	fumigaclavine C	13-28	interleukin 1 beta	Mus musculus	153-161
16023781-4	2005	Islets from iNOS-/- and wt mice exposed to IL-1beta or (IL-1beta + IFN-gamma) for 2-20 h showed different kinetics of glucose-stimulated insulin secretion.	Glucose	118-125	interleukin 1 beta	Mus musculus	43-51
16023781-4	2005	Islets from iNOS-/- and wt mice exposed to IL-1beta or (IL-1beta + IFN-gamma) for 2-20 h showed different kinetics of glucose-stimulated insulin secretion.	Glucose	118-125	interleukin 1 beta	Mus musculus	56-64
16023781-5	2005	In iNOS-/- islets, IL-1beta at high glucose induced a delayed and prolonged stimulation of insulin secretion, and this was followed by an increase in phospholipase D mRNA expression.	Glucose	36-43	interleukin 1 beta	Mus musculus	19-27
16101294-0	2005	IL-1beta epitope mapping using site-directed mutagenesis and hydrogen-deuterium exchange mass spectrometry analysis.	Deuterium	70-79	interleukin 1 beta	Mus musculus	0-8
16101294-9	2005	Hydrogen-deuterium exchange/mass spectrometry analysis confirmed that these regions of IL-1beta were protected from exchange because of antibody binding.	Hydrogen	0-8	interleukin 1 beta	Mus musculus	87-95
16101294-9	2005	Hydrogen-deuterium exchange/mass spectrometry analysis confirmed that these regions of IL-1beta were protected from exchange because of antibody binding.	Deuterium	9-18	interleukin 1 beta	Mus musculus	87-95
16055120-5	2005	Bio-Plex assay revealed that interleukin (IL)-1alpha, IL-1beta, and IL-6 secretion from RAW264.7 cells were also induced by unsaturated alginate oligomers with similar structure-activity relationship profiles as seen in TNF-alpha, and the most potent activities were observed with G8 and M7.	unsaturated alginate	124-144	interleukin 1 beta	Mus musculus	54-62
16038627-8	2005	The mRNA levels of COX-2, iNOS, TNF-alpha and IL-1beta were increased in LPS-activated macrophages and, except COX-2, reduced by pre-treatment with celecoxib.	Celecoxib	148-157	interleukin 1 beta	Mus musculus	46-54
16106098-0	2005	Release of IL-1beta via IL-1beta-converting enzyme in a skin dendritic cell line exposed to 2,4-dinitrofluorobenzene.	Dinitrofluorobenzene	92-116	interleukin 1 beta	Mus musculus	11-19
16106098-4	2005	The ICE inhibitor Z-YVAD-FMK prevented the release of IL-1beta evoked by DNFB.	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone	18-28	interleukin 1 beta	Mus musculus	54-62
16106098-4	2005	The ICE inhibitor Z-YVAD-FMK prevented the release of IL-1beta evoked by DNFB.	Dinitrofluorobenzene	73-77	interleukin 1 beta	Mus musculus	54-62
16106098-5	2005	Incubation of the cells with DNFB (30 minutes) strongly increased IL-1beta receptor immunoreactivity.	Dinitrofluorobenzene	29-33	interleukin 1 beta	Mus musculus	66-74
16106098-6	2005	The rapid effect of DNFB on the release of mature IL-1beta, without inducing an increase of IL-1beta mRNA in FSDC, suggests a posttranslational modification of pro-IL-1beta by ICE activity.	Dinitrofluorobenzene	20-24	interleukin 1 beta	Mus musculus	50-58
16038627-6	2005	The LPS-induced increases in the release of PGE2, NO, TNF-alpha and IL-1beta from macrophages were attenuated by pre-treatment with celecoxib.	Celecoxib	132-141	interleukin 1 beta	Mus musculus	68-76
15993445-7	2005	Similar comparisons also detected decreases in Fos-IR neurons induced by IL-1beta in the VLM A1, VLM C1 and NTS A2 catecholamine cell groups, area postrema, and parabrachial nucleus.	Catecholamines	115-128	interleukin 1 beta	Mus musculus	73-81
15996692-6	2005	Subdiaphragmatic vagotomy also attenuated the IL-1beta- and LPS-induced increases in plasma ACTH and corticosterone, but the attenuations of the responses to IL-1beta were only marginally significant.	Corticosterone	101-115	interleukin 1 beta	Mus musculus	46-54
15784009-6	2005	Death of ATDC5 cells after IL-1beta treatment was prevented by an NADPH-oxidase inhibitor, AEBSF[4-(2-aminoethyl)benzene-sulphonyl fluoride], an NO synthase inhibitor, L-NAME (NG-nitro-L-arginine methyl ester), and a ONOO- scavenger, uric acid.	4-(2-aminoethyl)benzenesulfonylfluoride	91-96	interleukin 1 beta	Mus musculus	27-35
15784009-0	2005	Interleukin-1beta induces death in chondrocyte-like ATDC5 cells through mitochondrial dysfunction and energy depletion in a reactive nitrogen and oxygen species-dependent manner.	reactive	124-132	interleukin 1 beta	Mus musculus	0-17
15784009-6	2005	Death of ATDC5 cells after IL-1beta treatment was prevented by an NADPH-oxidase inhibitor, AEBSF[4-(2-aminoethyl)benzene-sulphonyl fluoride], an NO synthase inhibitor, L-NAME (NG-nitro-L-arginine methyl ester), and a ONOO- scavenger, uric acid.	4-(2-aminoethyl)benzene-sulphonyl fluoride	97-139	interleukin 1 beta	Mus musculus	27-35
15784009-0	2005	Interleukin-1beta induces death in chondrocyte-like ATDC5 cells through mitochondrial dysfunction and energy depletion in a reactive nitrogen and oxygen species-dependent manner.	Nitrogen	133-141	interleukin 1 beta	Mus musculus	0-17
15784009-0	2005	Interleukin-1beta induces death in chondrocyte-like ATDC5 cells through mitochondrial dysfunction and energy depletion in a reactive nitrogen and oxygen species-dependent manner.	oxygen species	146-160	interleukin 1 beta	Mus musculus	0-17
15784009-6	2005	Death of ATDC5 cells after IL-1beta treatment was prevented by an NADPH-oxidase inhibitor, AEBSF[4-(2-aminoethyl)benzene-sulphonyl fluoride], an NO synthase inhibitor, L-NAME (NG-nitro-L-arginine methyl ester), and a ONOO- scavenger, uric acid.	NG-Nitroarginine Methyl Ester	168-174	interleukin 1 beta	Mus musculus	27-35
15784009-6	2005	Death of ATDC5 cells after IL-1beta treatment was prevented by an NADPH-oxidase inhibitor, AEBSF[4-(2-aminoethyl)benzene-sulphonyl fluoride], an NO synthase inhibitor, L-NAME (NG-nitro-L-arginine methyl ester), and a ONOO- scavenger, uric acid.	NG-Nitroarginine Methyl Ester	176-208	interleukin 1 beta	Mus musculus	27-35
15784009-6	2005	Death of ATDC5 cells after IL-1beta treatment was prevented by an NADPH-oxidase inhibitor, AEBSF[4-(2-aminoethyl)benzene-sulphonyl fluoride], an NO synthase inhibitor, L-NAME (NG-nitro-L-arginine methyl ester), and a ONOO- scavenger, uric acid.	onoo	217-221	interleukin 1 beta	Mus musculus	27-35
15784009-6	2005	Death of ATDC5 cells after IL-1beta treatment was prevented by an NADPH-oxidase inhibitor, AEBSF[4-(2-aminoethyl)benzene-sulphonyl fluoride], an NO synthase inhibitor, L-NAME (NG-nitro-L-arginine methyl ester), and a ONOO- scavenger, uric acid.	Uric Acid	234-243	interleukin 1 beta	Mus musculus	27-35
15784009-8	2005	Disruption of mitochondrial membrane potential and ATP deprivation were observed in IL-1beta-treated ATDC5 cells, both of which were restored by L-NAME, AEBSF or uric acid.	Adenosine Triphosphate	51-54	interleukin 1 beta	Mus musculus	84-92
15784009-8	2005	Disruption of mitochondrial membrane potential and ATP deprivation were observed in IL-1beta-treated ATDC5 cells, both of which were restored by L-NAME, AEBSF or uric acid.	NG-Nitroarginine Methyl Ester	145-151	interleukin 1 beta	Mus musculus	84-92
15784009-8	2005	Disruption of mitochondrial membrane potential and ATP deprivation were observed in IL-1beta-treated ATDC5 cells, both of which were restored by L-NAME, AEBSF or uric acid.	4-(2-aminoethyl)benzenesulfonylfluoride	153-158	interleukin 1 beta	Mus musculus	84-92
15784009-8	2005	Disruption of mitochondrial membrane potential and ATP deprivation were observed in IL-1beta-treated ATDC5 cells, both of which were restored by L-NAME, AEBSF or uric acid.	Uric Acid	162-171	interleukin 1 beta	Mus musculus	84-92
15784009-10	2005	These results suggest that the death of chondrocyte-like ATDC5 cells was mediated at least in part by mitochondrial dysfunction and energy depletion through ONOO- formation after IL-1beta treatment.	onoo	157-161	interleukin 1 beta	Mus musculus	179-187
15972630-3	2005	TMA induced early expression of IL-10, a cytokine implicated in the negative regulation of Langerhans cell (LC) migration, whereas exposure to DNCB resulted in production of the proinflammatory cytokine IL-1beta.	Dinitrochlorobenzene	143-147	interleukin 1 beta	Mus musculus	203-211
15949468-6	2005	RESULTS: Proinflammatory cytokines IL-1beta and TNFalpha up-regulated VCAM-1 ectodomain release from the MCEC-1 cells, and this was dependant on p38 and mitogen-activated protein kinases (MAP kinases) and inhibited by the matrix metalloproteinase (MMP) inhibitor BB94 and tissue inhibitor of metalloproteinase (TIMP)-3, but not TIMP-1 or TIMP-2.	batimastat	263-267	interleukin 1 beta	Mus musculus	35-43
15914323-4	2005	The compound K also significantly reduced the levels of mRNA of cyclooxygenase (COX)-2, IL-1beta, TNF-alpha, IFN-gamma and IL-4 increased in oxazolone-applied mouse ears.	Oxazolone	141-150	interleukin 1 beta	Mus musculus	88-96
15943814-6	2005	Interleukin-1beta (IL-1beta) alone, or in synergy with FGF-2/heparin strongly induced the gene in 3T3 fibroblasts.	Heparin	61-68	interleukin 1 beta	Mus musculus	0-17
15970368-3	2005	In that report, we found that the Abeta1-42-induced increases in immunoreactivities of glial fibrillary acidic protein, the astrocyte marker, and interleukin(IL)-1beta in the hippocampus are also suppressed by pretreatment with ferulic acid.	ferulic acid	228-240	interleukin 1 beta	Mus musculus	146-167
15987517-4	2005	The objective of this study was to test the hypothesis that parthenolide suppresses lipopolysaccharide (LPS)-induced serum (interleukin) IL-6, tumor necrosis factor (TNF)-alpha, IL-1beta and cyclooxygenase (COX)-2 expression in mice as indicated by reduced splenic and liver mRNA levels.	parthenolide	60-72	interleukin 1 beta	Mus musculus	178-186
15987517-10	2005	Induction of IL-6 mRNA was reduced, TNF-alpha and COX-2 mRNAs unchanged, and IL-1beta mRNA increased in spleens of parthenolide plus LPS co-treated animals compared to LPS-only.	parthenolide	115-127	interleukin 1 beta	Mus musculus	77-85
15921778-8	2005	Carvedilol attenuated over-expression of myocardial TGF-beta(1), IL-1beta and MMP-8 mRNA expression significantly and induced a relevant IL-10 mRNA expression in the infected mice (n=10).	Carvedilol	0-10	interleukin 1 beta	Mus musculus	65-73
15943814-6	2005	Interleukin-1beta (IL-1beta) alone, or in synergy with FGF-2/heparin strongly induced the gene in 3T3 fibroblasts.	Heparin	61-68	interleukin 1 beta	Mus musculus	19-27
15942563-7	2005	The dose effect of celecoxib was examined in vitro by studying cell proliferation, expression of cyclooxygenase-2 (mRNA and protein), and production of prostaglandin E 2 in unstimulated and interleukin 1beta-stimulated cells.	Celecoxib	19-28	interleukin 1 beta	Mus musculus	190-207
15986771-5	2005	However, IL-1beta enhanced the PGE2-induced increase of L-glutamate uptake.	Dinoprostone	31-35	interleukin 1 beta	Mus musculus	9-17
16082418-7	2005	The antagonist tamoxifen of E2 abolished the effects of E2 on TNF-alpha and IL-1beta whereas the antagonist cyproterone of Te did not alter the effects of Te on Ana-1.	Tamoxifen	15-24	interleukin 1 beta	Mus musculus	76-84
15986771-5	2005	However, IL-1beta enhanced the PGE2-induced increase of L-glutamate uptake.	Glutamic Acid	56-67	interleukin 1 beta	Mus musculus	9-17
15986771-7	2005	Kinetic analysis of L-glutamate uptake showed that PGE2 and PGE2 with IL-1beta increased V(max) value with no significant effect on Km value for Na(+)-dependent L-glutamate uptake.	Glutamic Acid	20-31	interleukin 1 beta	Mus musculus	70-78
15986771-7	2005	Kinetic analysis of L-glutamate uptake showed that PGE2 and PGE2 with IL-1beta increased V(max) value with no significant effect on Km value for Na(+)-dependent L-glutamate uptake.	Dinoprostone	51-55	interleukin 1 beta	Mus musculus	70-78
15986771-7	2005	Kinetic analysis of L-glutamate uptake showed that PGE2 and PGE2 with IL-1beta increased V(max) value with no significant effect on Km value for Na(+)-dependent L-glutamate uptake.	Dinoprostone	60-64	interleukin 1 beta	Mus musculus	70-78
15986771-9	2005	These results suggest that IL-1beta, IL-6 and PGE2 modulate glutamate transport of astrocytes and play a role in the pathogenesis of neurodegenerative disorders such as ALS and AD.	Glutamic Acid	60-69	interleukin 1 beta	Mus musculus	27-35
15775706-6	2005	However, at doses of 200 and 300 mg/kg, ASA or ACET significantly and dose-dependently attenuated pain behavior induced by TNF-alpha, IL-1beta or IFN-gamma administered intrathecally.	Aspirin	40-43	interleukin 1 beta	Mus musculus	134-142
15688088-0	2005	Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer"s models.	Ibuprofen	0-9	interleukin 1 beta	Mus musculus	21-38
15797891-5	2005	RESULTS: Rosiglitazone significantly decreased serum tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta levels during sepsis.	Rosiglitazone	9-22	interleukin 1 beta	Mus musculus	92-114
15797891-9	2005	In cultured tubular epithelial cells, rosiglitazone significantly decreased the expression of ICAM-1 and VCAM-1 induced by TNF-alpha or IL-1beta, inhibited the degradation of inhibitor kappaBalpha (IkappaBalpha) and blocked the activation of the p65 subunit of nuclear factor (NF)-kappaB.	Rosiglitazone	38-51	interleukin 1 beta	Mus musculus	136-144
15797891-10	2005	CONCLUSIONS: These results indicate that pre-treatment with rosiglitazone attenuated the production of TNF-alpha and IL-1beta and reduced adhesion molecule expression in renal tubular epithelial cells of LPS-treated mice.	Rosiglitazone	60-73	interleukin 1 beta	Mus musculus	117-125
15775706-6	2005	However, at doses of 200 and 300 mg/kg, ASA or ACET significantly and dose-dependently attenuated pain behavior induced by TNF-alpha, IL-1beta or IFN-gamma administered intrathecally.	Acetaminophen	47-51	interleukin 1 beta	Mus musculus	134-142
15775706-7	2005	Our results suggest that orally administered ASA and ACET produce antinociception by inhibiting the nociceptive action of TNF-alpha, IL-1beta or IFN-gamma administered intrathecally.	Aspirin	45-48	interleukin 1 beta	Mus musculus	133-141
15775706-7	2005	Our results suggest that orally administered ASA and ACET produce antinociception by inhibiting the nociceptive action of TNF-alpha, IL-1beta or IFN-gamma administered intrathecally.	Acetaminophen	53-57	interleukin 1 beta	Mus musculus	133-141
15897810-12	2005	Thalidomide also caused a substantial reduction of the rise in myeloperoxidase activity (mucosa), in the increase in the tissue levels of TNF-alpha, IL-1beta, and VEGF, in the increase in staining (immunohistochemistry) for nitrotyrosine and for poly (ADP ribose), as well as in the upregulation of intercellular adhesion molecule-1 caused by DNBS in the colon.	Thalidomide	0-11	interleukin 1 beta	Mus musculus	149-157
15910760-7	2005	The results showed that after MPTP treatment, striatal DA content was dramatically decreased, IL-1beta levels increased on day 3, while IL-6 levels increased on day 14.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	30-34	interleukin 1 beta	Mus musculus	94-102
15910760-12	2005	These results have clearly demonstrated our hypotheses, that MPTP can induce increase of plasma IL-1beta and IL-6 levels in mice, and this effect is shaped by behavioral lateralization.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	61-65	interleukin 1 beta	Mus musculus	96-104
15852394-2	2005	We report that peripheral administration of the acetylcholinesterase inhibitors tacrine, rivastigmine, neostigmine, or EN101 (an antisense oligonucleotide directed at acetylcholinesterase messenger RNA) to mice significantly attenuated the production of interleukin-1beta in the hippocampus and blood, concomitantly with the reduction in acetylcholinesterase activity.	EN101	119-124	interleukin 1 beta	Mus musculus	254-271
15879116-10	2005	In vivo, treatment of mice with DMSO significantly increased plasma levels of IL-1beta after endotoxin challenge.	Dimethyl Sulfoxide	32-36	interleukin 1 beta	Mus musculus	78-86
15826817-8	2005	EtOH and burn, as well as the combined injury, consistently and impressively reduced serum testosterone, while increasing hypothalamic concentrations of all three of the pro-inflammatory cytokines, TNFalpha, IL-1beta, and IL-6.	Ethanol	0-4	interleukin 1 beta	Mus musculus	208-216
15814605-0	2005	Induction of interleukin-1beta, tumour necrosis factor-alpha and apoptosis in mouse organs by amphotericin B is neutralized by conjugation with arabinogalactan.	Amphotericin B	94-108	interleukin 1 beta	Mus musculus	13-30
15885639-0	2005	Ethinyl estradiol treats collagen-induced arthritis in DBA/1LacJ mice by inhibiting the production of TNF-alpha and IL-1beta.	Ethinyl Estradiol	0-17	interleukin 1 beta	Mus musculus	116-124
15823272-8	2005	These results suggest that tilianin ameliorates atherosclerosis by inhibiting the production of the NF-kappaB-dependent pro-inflammatory cytokines, TNF-alpha and IL-1beta, via the inhibition of IkappaB kinase activity.	tilianin	27-35	interleukin 1 beta	Mus musculus	162-170
15814605-0	2005	Induction of interleukin-1beta, tumour necrosis factor-alpha and apoptosis in mouse organs by amphotericin B is neutralized by conjugation with arabinogalactan.	arabinogalactan	144-159	interleukin 1 beta	Mus musculus	13-30
15814605-11	2005	CONCLUSIONS: AMB-related toxicity is associated with induction of IL-1beta, TNF-alpha and apoptosis in organs.	Amphotericin B	13-16	interleukin 1 beta	Mus musculus	66-74
15814605-1	2005	OBJECTIVES: To investigate the possibilities that: (i) organ toxicity of amphotericin B-deoxycholate (AMB-DOC) is related to induction of interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and apoptosis in target organs; and (ii) the reduced toxicity resulting from the conjugation of AMB with water-soluble arabinogalactan (AMB-AG), is related to modulation of these parameters.	amphotericin B, deoxycholate drug combination	73-100	interleukin 1 beta	Mus musculus	138-155
15814605-1	2005	OBJECTIVES: To investigate the possibilities that: (i) organ toxicity of amphotericin B-deoxycholate (AMB-DOC) is related to induction of interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and apoptosis in target organs; and (ii) the reduced toxicity resulting from the conjugation of AMB with water-soluble arabinogalactan (AMB-AG), is related to modulation of these parameters.	amphotericin B, deoxycholate drug combination	73-100	interleukin 1 beta	Mus musculus	157-165
15814605-1	2005	OBJECTIVES: To investigate the possibilities that: (i) organ toxicity of amphotericin B-deoxycholate (AMB-DOC) is related to induction of interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and apoptosis in target organs; and (ii) the reduced toxicity resulting from the conjugation of AMB with water-soluble arabinogalactan (AMB-AG), is related to modulation of these parameters.	amphotericin B, deoxycholate drug combination	102-109	interleukin 1 beta	Mus musculus	138-155
15814605-1	2005	OBJECTIVES: To investigate the possibilities that: (i) organ toxicity of amphotericin B-deoxycholate (AMB-DOC) is related to induction of interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and apoptosis in target organs; and (ii) the reduced toxicity resulting from the conjugation of AMB with water-soluble arabinogalactan (AMB-AG), is related to modulation of these parameters.	amphotericin B, deoxycholate drug combination	102-109	interleukin 1 beta	Mus musculus	157-165
15814605-1	2005	OBJECTIVES: To investigate the possibilities that: (i) organ toxicity of amphotericin B-deoxycholate (AMB-DOC) is related to induction of interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and apoptosis in target organs; and (ii) the reduced toxicity resulting from the conjugation of AMB with water-soluble arabinogalactan (AMB-AG), is related to modulation of these parameters.	Amphotericin B	102-105	interleukin 1 beta	Mus musculus	138-155
15814605-1	2005	OBJECTIVES: To investigate the possibilities that: (i) organ toxicity of amphotericin B-deoxycholate (AMB-DOC) is related to induction of interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and apoptosis in target organs; and (ii) the reduced toxicity resulting from the conjugation of AMB with water-soluble arabinogalactan (AMB-AG), is related to modulation of these parameters.	Amphotericin B	102-105	interleukin 1 beta	Mus musculus	157-165
15814605-10	2005	Treatment with AMB-AG (but not AmBisome) appears to uniquely modulate the in situ expression of IL-1beta and enhance secretion of TNF-alpha in kidneys, effects possibly involved in prevention of apoptosis.	amb-ag	15-21	interleukin 1 beta	Mus musculus	96-104
15836969-3	2005	We report that administration of a neutral dose of IL-1beta abolished morphine analgesia in mice, whereas acute or chronic blockade of IL-1 signaling by various IL-1 blockers (IL-1 receptor antagonist (IL-1ra), alpha-melanocyte-stimulating hormone, or IL-1 tri-peptide antagonist) significantly prolonged and potentiated morphine analgesia.	Morphine	70-78	interleukin 1 beta	Mus musculus	51-59
15790955-5	2005	Two synthetic LXR ligands, T0901317 and GW3965, inhibited TNF-alpha, IL-1beta, INF-gamma and lipopolysaccharide induced OPN mRNA and protein expression in RAW 264.7 macrophages.	T0901317	27-35	interleukin 1 beta	Mus musculus	69-77
15814731-9	2005	Trehalose dimycolate, when delivered to bone marrow-derived murine macrophages, induced the greatest secretion of IL-1beta, IL-6, and TNF-alpha in vitro.	Cord Factors	0-20	interleukin 1 beta	Mus musculus	114-122
15790955-5	2005	Two synthetic LXR ligands, T0901317 and GW3965, inhibited TNF-alpha, IL-1beta, INF-gamma and lipopolysaccharide induced OPN mRNA and protein expression in RAW 264.7 macrophages.	GW 3965	40-46	interleukin 1 beta	Mus musculus	69-77
15814801-4	2005	Both SDM and cMMP-3 induced generation of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), IL-1beta, and interleukin-1 receptor antagonist but not IL-12 and inducible nitric oxide synthase, which are readily induced by lipopolysaccharide, in microglia, suggesting that there is a characteristic pattern of microglial cytokine induction by apoptotic neurons.	SDM	5-8	interleukin 1 beta	Mus musculus	105-113
15814801-4	2005	Both SDM and cMMP-3 induced generation of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), IL-1beta, and interleukin-1 receptor antagonist but not IL-12 and inducible nitric oxide synthase, which are readily induced by lipopolysaccharide, in microglia, suggesting that there is a characteristic pattern of microglial cytokine induction by apoptotic neurons.	cmmp-3	13-19	interleukin 1 beta	Mus musculus	105-113
15761213-8	2005	Albumin and PMN content in LPS-injured lungs were reduced to levels found in female mice after administration of estradiol in OVX mice and corresponded to reduced IL-1beta, IL-6, and ICAM-1 levels.	Estradiol	113-122	interleukin 1 beta	Mus musculus	163-171
15883739-6	2005	In the presence of IL-1beta, PGE2, 15d-PGJ2, 6-keto PGF1alpha and PGF2alpha each enhanced COX-2 protein expression between 5- to 20-fold.	Dinoprostone	29-33	interleukin 1 beta	Mus musculus	19-27
15781526-6	2005	In the presence of LPS or SAC, proinflammatory cytokine (TNF-alpha and IL-1beta) production was increased after carrageenan.	Carrageenan	112-123	interleukin 1 beta	Mus musculus	71-79
15883736-11	2005	CONCLUSIONS: Rofecoxib is protective in acute DSS-induced colitis, probably by reducing neutrophil infiltration, inhibiting up-regulation of IL-1beta and returning to normal COX-1 expression in the inflamed colonic mucosa.	rofecoxib	13-22	interleukin 1 beta	Mus musculus	141-149
15883739-6	2005	In the presence of IL-1beta, PGE2, 15d-PGJ2, 6-keto PGF1alpha and PGF2alpha each enhanced COX-2 protein expression between 5- to 20-fold.	15-deoxy-delta(12,14)-prostaglandin J2	35-43	interleukin 1 beta	Mus musculus	19-27
15883739-6	2005	In the presence of IL-1beta, PGE2, 15d-PGJ2, 6-keto PGF1alpha and PGF2alpha each enhanced COX-2 protein expression between 5- to 20-fold.	6-Ketoprostaglandin F1 alpha	45-61	interleukin 1 beta	Mus musculus	19-27
15883739-6	2005	In the presence of IL-1beta, PGE2, 15d-PGJ2, 6-keto PGF1alpha and PGF2alpha each enhanced COX-2 protein expression between 5- to 20-fold.	Dinoprost	66-75	interleukin 1 beta	Mus musculus	19-27
15883739-9	2005	None of the PG metabolites tested showed significant effects on the level of COX-1 or cPLA2 protein expression, except for PGF2alpha, which increased IL-1beta-induced cPLA2 protein expression slightly.	Dinoprost	123-132	interleukin 1 beta	Mus musculus	150-158
15748950-3	2005	The results show that TZDs and 15d-PGJ(2) are effective in inhibiting production of nitric oxide, the pro-inflammatory cytokines TNF-alpha, IL-1beta, and IL-6, and the chemokine MCP-1 from microglia and astrocytes.	Thiazolidinediones	22-26	interleukin 1 beta	Mus musculus	140-148
15748950-3	2005	The results show that TZDs and 15d-PGJ(2) are effective in inhibiting production of nitric oxide, the pro-inflammatory cytokines TNF-alpha, IL-1beta, and IL-6, and the chemokine MCP-1 from microglia and astrocytes.	15d-pgj	31-38	interleukin 1 beta	Mus musculus	140-148
15749024-5	2005	Recombinant mouse IL-1beta induced strong activation of ERK1/2, p38, JNK and NFkappa B, and significant release of IL-6 and PGE2, which was blocked by IL-1ra.	Dinoprostone	124-128	interleukin 1 beta	Mus musculus	18-26
15781291-13	2005	Meanwhile, cotreatment with ketamine and lipopolysaccharide significantly inhibited lipopolysaccharide-induced TNF-alpha, IL-1beta, and IL-6 mRNA levels.	Ketamine	28-36	interleukin 1 beta	Mus musculus	122-130
16011257-4	2005	The interleukin-1beta (IL-1beta) levels in mice serum and in supernatants of U937 cell culture stimulated by phorbol 12-myristate 13-acetate (PMA) were detected by radioimmunoassay (RIA).	Tetradecanoylphorbol Acetate	109-140	interleukin 1 beta	Mus musculus	4-21
16011257-4	2005	The interleukin-1beta (IL-1beta) levels in mice serum and in supernatants of U937 cell culture stimulated by phorbol 12-myristate 13-acetate (PMA) were detected by radioimmunoassay (RIA).	Tetradecanoylphorbol Acetate	109-140	interleukin 1 beta	Mus musculus	23-31
16011257-4	2005	The interleukin-1beta (IL-1beta) levels in mice serum and in supernatants of U937 cell culture stimulated by phorbol 12-myristate 13-acetate (PMA) were detected by radioimmunoassay (RIA).	Tetradecanoylphorbol Acetate	142-145	interleukin 1 beta	Mus musculus	4-21
16011257-4	2005	The interleukin-1beta (IL-1beta) levels in mice serum and in supernatants of U937 cell culture stimulated by phorbol 12-myristate 13-acetate (PMA) were detected by radioimmunoassay (RIA).	Tetradecanoylphorbol Acetate	142-145	interleukin 1 beta	Mus musculus	23-31
16011257-13	2005	CONCLUSION: Ginkgolide B was shown to significantly inhibit angiogenesis of the murine chronic granulomatous air pouch model, reduce the IL-1beta and TNF-alpha levels in mice serums, and significantly inhibit IL-1beta and TNF-alpha mRNA expression and protein secretion in supernatants of U937 cell culture.	ginkgolide B	12-24	interleukin 1 beta	Mus musculus	137-145
16011257-13	2005	CONCLUSION: Ginkgolide B was shown to significantly inhibit angiogenesis of the murine chronic granulomatous air pouch model, reduce the IL-1beta and TNF-alpha levels in mice serums, and significantly inhibit IL-1beta and TNF-alpha mRNA expression and protein secretion in supernatants of U937 cell culture.	ginkgolide B	12-24	interleukin 1 beta	Mus musculus	209-217
16011257-14	2005	It was suggested that reduction of proangiogenic cytokines IL-1beta and TNF-alpha secretion may contribute to the anti-angiogenesis effect of ginkgolide B in the murine chronic granulomatous air pouch model.	ginkgolide B	142-154	interleukin 1 beta	Mus musculus	59-67
15578659-6	2005	Glybenclamide and diisothiocyanato-stilbene-disulfonic acid (DIDS), two blockers of chloride fluxes that drive the export activity of ABC1 transporters, inhibited IL-1beta release without altering its intracellular processing.	Glyburide	0-13	interleukin 1 beta	Mus musculus	163-171
16046848-4	2005	Unilateral HI was induced at postnatal day 9 in IL-1beta, IL-1beta18, and IL-1alphabeta knockout and wild-type mice and brain injury was evaluated 1 week later.	hi	11-13	interleukin 1 beta	Mus musculus	48-56
15749906-6	2005	Using an intratracheal bacterial endotoxin LPS challenge model, we found that the reduced survival in FRH-treated mice was accompanied by increased pulmonary vascular endothelial injury, enhanced pulmonary accumulation of neutrophils, increased levels of IL-1beta, MIP-2/CXCL213, GM-CSF, and KC/CXCL1 in the bronchoalveolar lavage fluid, and bronchiolar epithelial necrosis.	frh	102-105	interleukin 1 beta	Mus musculus	255-263
15710982-10	2005	Similarly, subcutaneous infusion of losartan suppressed colitis (p&lt;0.05) and the production of proinflammatory cytokines (IL-1beta, IFN-gamma).	Losartan	36-44	interleukin 1 beta	Mus musculus	125-133
15578659-6	2005	Glybenclamide and diisothiocyanato-stilbene-disulfonic acid (DIDS), two blockers of chloride fluxes that drive the export activity of ABC1 transporters, inhibited IL-1beta release without altering its intracellular processing.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	61-65	interleukin 1 beta	Mus musculus	163-171
15578659-6	2005	Glybenclamide and diisothiocyanato-stilbene-disulfonic acid (DIDS), two blockers of chloride fluxes that drive the export activity of ABC1 transporters, inhibited IL-1beta release without altering its intracellular processing.	Chlorides	84-92	interleukin 1 beta	Mus musculus	163-171
15578659-7	2005	Enhancing chloride efflux potentiated the release of IL-1beta, while decreasing it led to a strong reduction in its release.	Chlorides	10-18	interleukin 1 beta	Mus musculus	53-61
15789752-4	2005	Moreover, scoparone also attenuated the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in LPS-stimulated RAW264.7 cells.	scoparone	10-19	interleukin 1 beta	Mus musculus	89-111
15710461-0	2005	Autocrine actions of macrophage-derived catecholamines on interleukin-1 beta.	Catecholamines	40-54	interleukin 1 beta	Mus musculus	58-76
15710461-1	2005	Previous studies indicate that norepinephrine and epinephrine modulate production of interleukin-1(beta) (IL-1(beta)) by activated macrophages, but it is not known if macrophage-derived catecholamines affect IL-1(beta).	Norepinephrine	31-45	interleukin 1 beta	Mus musculus	85-104
15710461-1	2005	Previous studies indicate that norepinephrine and epinephrine modulate production of interleukin-1(beta) (IL-1(beta)) by activated macrophages, but it is not known if macrophage-derived catecholamines affect IL-1(beta).	Norepinephrine	31-45	interleukin 1 beta	Mus musculus	106-116
15710461-1	2005	Previous studies indicate that norepinephrine and epinephrine modulate production of interleukin-1(beta) (IL-1(beta)) by activated macrophages, but it is not known if macrophage-derived catecholamines affect IL-1(beta).	Epinephrine	34-45	interleukin 1 beta	Mus musculus	85-104
15838484-9	2005	PDTC-treated mice also exhibited significantly lower serum and aortic wall concentrations of interleukin 1beta and interleukin 6, as well as lower amounts of aortic wall MMP-9, as compared with saline-treated controls.	pyrrolidine dithiocarbamic acid	0-4	interleukin 1 beta	Mus musculus	93-110
15652277-8	2005	Administration of UD significantly suppressed the progression of CIA and inhibited the production of TNF-alpha and IL-1beta in the paws.	UD	18-20	interleukin 1 beta	Mus musculus	115-123
15710461-3	2005	Treatment with the beta-adrenergic receptor antagonists propranolol or ICI 118,551 increased LPS-induced production of IL-1(beta), whereas treatment with the alpha-adrenergic antagonists phentolamine or yohimbine decreased IL-1(beta).	Propranolol	56-67	interleukin 1 beta	Mus musculus	119-129
15710461-3	2005	Treatment with the beta-adrenergic receptor antagonists propranolol or ICI 118,551 increased LPS-induced production of IL-1(beta), whereas treatment with the alpha-adrenergic antagonists phentolamine or yohimbine decreased IL-1(beta).	Propranolol	56-67	interleukin 1 beta	Mus musculus	223-233
15710461-3	2005	Treatment with the beta-adrenergic receptor antagonists propranolol or ICI 118,551 increased LPS-induced production of IL-1(beta), whereas treatment with the alpha-adrenergic antagonists phentolamine or yohimbine decreased IL-1(beta).	Phentolamine	187-199	interleukin 1 beta	Mus musculus	223-233
15710461-4	2005	These findings demonstrate that adrenergic receptor antagonists unmask autocrine actions of macrophage-derived catecholamines on IL-1(beta) that may influence the inflammatory response.	Catecholamines	111-125	interleukin 1 beta	Mus musculus	129-139
15718919-4	2005	Plasma concentrations of IL-1beta, IL-6, macrophage inflammatory protein (MIP)-2, and IL-10 were also decreased in burned mice treated with glucan phosphate compared with vehicle-treated controls.	glucan phosphate	140-156	interleukin 1 beta	Mus musculus	25-33
15652231-8	2005	Further, DSS-induced increases in colonic mucosal IL-1 beta levels were blunted significantly in rutin-, but not quercetin-, fed mice (P&lt;0.01), while dietary rutin attenuated the expressions of IL-1 beta and IL-6 mRNA in colonic mucosa (each, P&lt;0.01).	Dextran Sulfate	9-12	interleukin 1 beta	Mus musculus	50-59
15652231-8	2005	Further, DSS-induced increases in colonic mucosal IL-1 beta levels were blunted significantly in rutin-, but not quercetin-, fed mice (P&lt;0.01), while dietary rutin attenuated the expressions of IL-1 beta and IL-6 mRNA in colonic mucosa (each, P&lt;0.01).	Dextran Sulfate	9-12	interleukin 1 beta	Mus musculus	197-206
15681167-5	2005	Deoxynivalenol was found to readily induce expression of cytokines (IL-1alpha, IL-1beta, and IL-6 and IL-11), chemokines (MCP-1, MCP-3, CINC-1 and MIP-2), components of the activator protein-1 (AP-1) transcription factor complex (c-Fos, Fra-2, c-Jun and JunB), as well as two hydrolases (MKP1, CnAbeta).	deoxynivalenol	0-14	interleukin 1 beta	Mus musculus	79-87
15652231-8	2005	Further, DSS-induced increases in colonic mucosal IL-1 beta levels were blunted significantly in rutin-, but not quercetin-, fed mice (P&lt;0.01), while dietary rutin attenuated the expressions of IL-1 beta and IL-6 mRNA in colonic mucosa (each, P&lt;0.01).	Rutin	97-102	interleukin 1 beta	Mus musculus	50-59
15652231-10	2005	Notably, a 0.1% rutin diet given 3 days after DSS treatment significantly suppressed both colorectal shortening and IL-1 beta production (P&lt;0.05 and &lt;0.01, respectively).	Rutin	16-21	interleukin 1 beta	Mus musculus	116-125
15539457-5	2005	In both models, GoH3 significantly inhibited neutrophil transmigration induced by IL-1beta but not TNF-alpha.	goh3	16-20	interleukin 1 beta	Mus musculus	82-90
15803864-0	2005	Effects of antioxidants coenzyme Q10 and lipoic acid on interleukin-1 beta-mediated inhibition of glucose-stimulated insulin release from cultured mouse pancreatic islets.	Thioctic Acid	41-52	interleukin 1 beta	Mus musculus	56-74
15622543-7	2005	Mice deficient in IL-1 receptor-associated kinase 4 (IRAK-4), which is pivotal for both IL-1beta and IL-18 signal transduction, were protected against oxygen-mediated neurotoxicity.	Oxygen	151-157	interleukin 1 beta	Mus musculus	88-96
15649273-7	2005	Results Topical prednisolone (0.05 mg/ear/day) significantly inhibited the increases in ear swelling and production of IL-1beta, IL-4, IL-18, granulocyte-macrophage colony-stimulating factor (GM-CSF) and histamine.	Prednisolone	16-28	interleukin 1 beta	Mus musculus	119-127
15649273-9	2005	The sequential treatment with olopatadine (10 mg/kg/day) after discontinuation of the treatment with topical prednisolone alone, or topical prednisolone with olopatadine, significantly inhibited the increases in ear swelling and levels of IL-1beta, IL-4, IL-18, GM-CSF, nerve growth factor and histamine.	Olopatadine Hydrochloride	30-41	interleukin 1 beta	Mus musculus	239-247
15665080-4	2005	IL-1ra and indomethacin pretreatment strongly inhibited the hypernociception induced by IL-1beta, which was not altered by AbKC or guanethidine or by knocking out TNF-R1.	Indomethacin	11-23	interleukin 1 beta	Mus musculus	88-96
15626366-4	2005	As a control, PTX pretreatment was effective at abrogating lethality and serum TNF-alpha increments in mice subjected to endotoxemia induced by injection of Escherichia coli lipopolysaccharide, although it did not affect the increment in IL-1beta and IL-6 in such endotoxic model.	Pentoxifylline	14-17	interleukin 1 beta	Mus musculus	238-246
15367390-5	2005	Results indicate that a 39-bp region (CEC) containing a cAMP-responsive element, an E-box, and a steroid receptor-binding site, previously identified as the most critical elements for enhancer activity, is sufficient for the inhibition induced by IL-1beta.	Cyclic AMP	56-60	interleukin 1 beta	Mus musculus	247-255
15803864-0	2005	Effects of antioxidants coenzyme Q10 and lipoic acid on interleukin-1 beta-mediated inhibition of glucose-stimulated insulin release from cultured mouse pancreatic islets.	Glucose	98-105	interleukin 1 beta	Mus musculus	56-74
15803864-5	2005	In this study, the antioxidants coenzyme Q10 and lipoic acid were able to block IL-1beta-mediated inhibition of glucose-stimulated insulin secretion from islet cells at 10(-12) M and 10(-9) M, respectively.	Thioctic Acid	49-60	interleukin 1 beta	Mus musculus	80-88
15803864-5	2005	In this study, the antioxidants coenzyme Q10 and lipoic acid were able to block IL-1beta-mediated inhibition of glucose-stimulated insulin secretion from islet cells at 10(-12) M and 10(-9) M, respectively.	Glucose	112-119	interleukin 1 beta	Mus musculus	80-88
15808609-7	2005	In vitro study revealed that rosiglitazone inhibited the lipopolysaccharide-induced secretion of interleukin-1 beta and interferon-gamma from peritoneal exudate cells.	Rosiglitazone	29-42	interleukin 1 beta	Mus musculus	97-115
15589033-8	2005	The results showed that MPTP treatment induced dramatic loss of DA in striatum, simultaneously, IL-6 levels decreased in the striatum and increased in hippocampus and hypothalamus, while IL-1beta levels decreased in the striatum, cerebral cortex and hippocampus.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	24-28	interleukin 1 beta	Mus musculus	187-195
15589033-11	2005	Behavioral lateralization also influenced IL-6 hippocampal levels under basal conditions and IL-1beta cortical levels after MPTP.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	124-128	interleukin 1 beta	Mus musculus	93-101
16194934-5	2005	Expression of Znf216 was also induced by other cytokines such as TNFalpha and IL-1beta.	znf216	14-20	interleukin 1 beta	Mus musculus	78-86
15722603-8	2005	We also found the cytokine response against CADS, levels of inflammatory cytokines interleukin-1 beta, tumor necrosis factor-alpha, and interleukin-6 in sera increased within 24 hr after CADS injection.	cads	187-191	interleukin 1 beta	Mus musculus	83-130
15964075-4	2005	The efficacy of the PolyI:C challenge to induce cytokine responses in naive non-pregnant adult female mice and in foetal brain tissue when injected to pregnant mice were further ascertained in separate subjects: (i) a dose-dependent elevation of interleukin-10 was detected in the adult female mice at 1 and 6h post-injection, (ii) 12 h following prenatal PolyI:C challenge, the foetal levels of interleukin-1beta were elevated.	polyi:c	20-27	interleukin 1 beta	Mus musculus	396-413
15579433-4	2004	We found increased chronic CB3-induced myocarditis (14.1 to 43.1%, P &lt; 0.001); pericarditis (1.5 to 7.6%, P &lt; 0.001); fibrosis (9.7 to 27.4%, P &lt; 0.05); and the profibrotic cytokines transforming growth factor-beta(1), IL-1 beta, and IL-4 in the hearts of IFN-gamma-deficient mice.	CB 3717	27-30	interleukin 1 beta	Mus musculus	228-237
15567193-6	2004	Analysis of IL-1beta, IL-6, TNF-alpha, IL-12 and iNOS mRNA expression in liver samples taken at 90 min post-LPS showed a marked reduction of the two latter mRNAs in BZL-treated mice.	benzonidazole	165-168	interleukin 1 beta	Mus musculus	12-20
15447943-3	2004	AraLAM induced high lung levels of tumor necrosis factor, interleukin-1beta, interleukin-6, and cytokine-induced neutrophil chemoattractant (KC) and an influx of neutrophils into the pulmonary compartment of WT mice.	aralam	0-6	interleukin 1 beta	Mus musculus	58-75
15585886-10	2004	Moreover, Fas-deficient mice showed enhanced systemic inflammatory arthritis associated with up-regulation of IL-1beta and CCL2 secretion, elevated numbers of inflammatory monocytes, and increased numbers of tissue macrophages.	ammonium ferrous sulfate	10-13	interleukin 1 beta	Mus musculus	110-118
15531295-4	2004	We also found that piperine could reduce the expression of IL-1beta, IL-6, TNF-alpha, GM-CSF and IL-12p40 genes.	piperine	19-27	interleukin 1 beta	Mus musculus	59-67
15606507-5	2004	Both preventive and therapeutic administration of olopatadine (10 mg kg(-1) day(-1)) significantly inhibited the ear swelling and the increased production of interleukin (IL)-4, IL-1beta, granulocyte-macrophage colony-stimulating factor (GM-CSF) and nerve growth factor.	Olopatadine Hydrochloride	50-61	interleukin 1 beta	Mus musculus	178-186
15313472-1	2004	Cyclooxygenase-2 (COX-2) and tyrosine kinase, which are involved in the biosynthesis of prostaglandin E(2) (PGE(2)) in mouse calvarial osteoblasts, are stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6).	Dinoprostone	88-106	interleukin 1 beta	Mus musculus	175-192
15669185-0	2004	U0126 prevents ERK pathway phosphorylation and interleukin-1beta mRNA production after cerebral ischemia.	U 0126	0-5	interleukin 1 beta	Mus musculus	47-64
15669185-12	2004	The protective effect of U0126 against ischemic injury is probably resulted from the reduction of IL-1beta mRNA via the inhibition of ERK pathway.	U 0126	25-30	interleukin 1 beta	Mus musculus	98-106
15604057-7	2004	CONCLUSIONS: Curcumin could modulate the expressions of IL-1beta and IL-10 mRNA in murine model of IBD, which suggests the potential of curcumin as a targeted therapeutic agent for IBD.	Curcumin	13-21	interleukin 1 beta	Mus musculus	56-64
15604057-7	2004	CONCLUSIONS: Curcumin could modulate the expressions of IL-1beta and IL-10 mRNA in murine model of IBD, which suggests the potential of curcumin as a targeted therapeutic agent for IBD.	Curcumin	136-144	interleukin 1 beta	Mus musculus	56-64
15621702-6	2004	Extending the in vitro results, we showed that the pre-treatment of mice with butyl, octyl and CAPE derivatives inhibited carrageenan-induced paw edema and prevented the increase in IL-1beta levels in the mouse paw by 30, 24 and 36%, respectively.	butyl, octyl and cape	78-99	interleukin 1 beta	Mus musculus	182-190
15557632-4	2004	The DeltafbpA mutant induced a stronger expression of pulmonary mRNA messages in mice for tumor necrosis factor alpha, interleukin-1 beta (IL-1beta), gamma interferon, IL-6, IL-2, and inducible nitric oxide (NO) synthase, which led to its decline, while H37Rv persisted despite strong immune responses.	deltafbpa	4-13	interleukin 1 beta	Mus musculus	119-137
15557632-4	2004	The DeltafbpA mutant induced a stronger expression of pulmonary mRNA messages in mice for tumor necrosis factor alpha, interleukin-1 beta (IL-1beta), gamma interferon, IL-6, IL-2, and inducible nitric oxide (NO) synthase, which led to its decline, while H37Rv persisted despite strong immune responses.	deltafbpa	4-13	interleukin 1 beta	Mus musculus	139-147
15297440-0	2004	Inhibition of hepatic gluconeogenesis and enhanced glucose uptake contribute to the development of hypoglycemia in mice bearing interleukin-1beta- secreting tumor.	Glucose	51-58	interleukin 1 beta	Mus musculus	128-145
15297440-1	2004	Mice bearing IL-1beta-secreting tumor were used to study the chronic effect of IL-1beta on glucose metabolism.	Glucose	91-98	interleukin 1 beta	Mus musculus	79-87
15297440-4	2004	Secretion of IL-1beta from the developed tumors was associated with decreased food consumption, reduced body weight, and reduced blood glucose levels.	Blood Glucose	129-142	interleukin 1 beta	Mus musculus	13-21
15297440-11	2004	We concluded that both decreased glucose production by the liver and enhanced glucose disposal lead to the development of hypoglycemia in mice bearing IL-1beta-secreting tumor.	Glucose	33-40	interleukin 1 beta	Mus musculus	151-159
15297440-11	2004	We concluded that both decreased glucose production by the liver and enhanced glucose disposal lead to the development of hypoglycemia in mice bearing IL-1beta-secreting tumor.	Glucose	78-85	interleukin 1 beta	Mus musculus	151-159
15313472-6	2004	A novel Src tyrosine kinase inhibitor, Herbimycin A (HERB), reduced COX-2 mRNA levels as well as PGE(2) production induced by IL-1beta, TNF-alpha and IL-6 or a combination of IL-1beta, TNF-alpha, IL-6, whereas COX-1 mRNA levels remained unaffected.	Dinoprostone	97-103	interleukin 1 beta	Mus musculus	126-134
15313472-1	2004	Cyclooxygenase-2 (COX-2) and tyrosine kinase, which are involved in the biosynthesis of prostaglandin E(2) (PGE(2)) in mouse calvarial osteoblasts, are stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6).	Dinoprostone	88-106	interleukin 1 beta	Mus musculus	194-202
15313472-1	2004	Cyclooxygenase-2 (COX-2) and tyrosine kinase, which are involved in the biosynthesis of prostaglandin E(2) (PGE(2)) in mouse calvarial osteoblasts, are stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6).	Prostaglandins E	108-111	interleukin 1 beta	Mus musculus	175-192
15313472-1	2004	Cyclooxygenase-2 (COX-2) and tyrosine kinase, which are involved in the biosynthesis of prostaglandin E(2) (PGE(2)) in mouse calvarial osteoblasts, are stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6).	Prostaglandins E	108-111	interleukin 1 beta	Mus musculus	194-202
15313472-3	2004	Simultaneous treatment with IL-6 and IL-1beta and TNF-alpha resulted in enhanced COX-2 mRNA levels accompanied by the cooperative stimulation of PGE(2) biosynthesis compared to cells treated with IL-1beta or TNF-alpha or IL-6 alone.	Prostaglandins E	145-148	interleukin 1 beta	Mus musculus	37-45
15313472-6	2004	A novel Src tyrosine kinase inhibitor, Herbimycin A (HERB), reduced COX-2 mRNA levels as well as PGE(2) production induced by IL-1beta, TNF-alpha and IL-6 or a combination of IL-1beta, TNF-alpha, IL-6, whereas COX-1 mRNA levels remained unaffected.	herbimycin	39-51	interleukin 1 beta	Mus musculus	126-134
15313472-6	2004	A novel Src tyrosine kinase inhibitor, Herbimycin A (HERB), reduced COX-2 mRNA levels as well as PGE(2) production induced by IL-1beta, TNF-alpha and IL-6 or a combination of IL-1beta, TNF-alpha, IL-6, whereas COX-1 mRNA levels remained unaffected.	herbimycin	39-51	interleukin 1 beta	Mus musculus	175-183
15465599-5	2004	This was further supported by the ethanol inhibition of LPS-induced IL-1beta expression.	Ethanol	34-41	interleukin 1 beta	Mus musculus	68-76
15557818-3	2004	Both plasminogen and gangliosides induced IL-1beta, TNF-alpha and iNOS mRNA expression, and that this expression was inhibited by the addition of the PKA inhibitors, KT5720 and H89.	Gangliosides	21-33	interleukin 1 beta	Mus musculus	42-50
15380476-6	2004	Clodronate (0.01, 0.1, 1 microg/ml) significantly down-regulated the LPS-stimulated microglial secretion of tumor necrosis factor (TNF)-alpha, Interleukin (IL)-1beta and NO, but not of IL-6.	Clodronic Acid	0-10	interleukin 1 beta	Mus musculus	143-165
15476220-10	2004	FK228 treatment induced histone hyperacetylation in the synovial cells and decreased the levels of tumor necrosis factor alpha and interleukin-1beta in the synovial tissues of mice with AMA.	romidepsin	0-5	interleukin 1 beta	Mus musculus	131-148
15476226-10	2004	Only prednisolone significantly reduced the expression of TNFalpha, IL-1beta, and IL-6 in the joints.	Prednisolone	5-17	interleukin 1 beta	Mus musculus	68-76
15476247-0	2004	Severity of murine collagen-induced arthritis correlates with increased CYP7B activity: enhancement of dehydroepiandrosterone metabolism by interleukin-1beta.	Dehydroepiandrosterone	103-125	interleukin 1 beta	Mus musculus	140-157
15476247-11	2004	Incubation of FLS with IL-1beta resulted in a dose-dependent increase in 7alpha-OH-DHEA formation.	7alpha-Hydroxydehydroepiandrosterone	73-87	interleukin 1 beta	Mus musculus	23-31
15466171-2	2004	The nitric oxide synthase (NOS2) is induced by inflammatory cytokines, e.g., tumor necrosis factor alpha and interleukin 1beta, and produces nitric oxide (NO*), a critical mediator of the inflammatory response.	Nitric Oxide	4-16	interleukin 1 beta	Mus musculus	109-126
15516795-0	2004	Role of IL-6 and IL-1beta in reactivation by acetylcholine of latently infecting pseudorabies virus.	Acetylcholine	45-58	interleukin 1 beta	Mus musculus	17-25
15516795-4	2004	IL-6 and IL-1beta were detected in mice after stimulation with acetylcholine.	Acetylcholine	63-76	interleukin 1 beta	Mus musculus	9-17
15371230-7	2004	DON was found to induce the cytokines interleukin (IL)-1alpha, IL-1beta, IL-6 and IL-11.	deoxynivalenol	0-3	interleukin 1 beta	Mus musculus	63-71
15385641-0	2004	Maitotoxin induces biphasic interleukin-1beta secretion and membrane blebbing in murine macrophages.	maitotoxin	0-10	interleukin 1 beta	Mus musculus	28-45
15385641-3	2004	We therefore tested whether MTX treatment of lipopolysaccharide-primed murine macrophages would mimic the ability of activated P2X7R to induce secretion of the proinflammatory cytokine interleukin-1beta (IL-1beta).	maitotoxin	28-31	interleukin 1 beta	Mus musculus	185-202
15385641-4	2004	MTX at &lt; or = 0.6 nM predominantly induced processing and nonlytic release of mature IL-1beta (mIL-1beta), whereas &gt;0.6 nM of MTX induced cytolytic release of unprocessed proIL-1beta.	maitotoxin	0-3	interleukin 1 beta	Mus musculus	88-96
15385641-4	2004	MTX at &lt; or = 0.6 nM predominantly induced processing and nonlytic release of mature IL-1beta (mIL-1beta), whereas &gt;0.6 nM of MTX induced cytolytic release of unprocessed proIL-1beta.	maitotoxin	0-3	interleukin 1 beta	Mus musculus	98-107
15385641-5	2004	MTX-dependent release of mIL-1beta (but not cytolysis) was inhibited by the elimination of the trans-plasma membrane K+ gradient.	maitotoxin	0-3	interleukin 1 beta	Mus musculus	25-34
15385641-11	2004	These results indicate that the inflammatory macrophage can assemble the necessary signaling components to initiate both regulated and lytic release of IL-1beta in response to MTX.	maitotoxin	176-179	interleukin 1 beta	Mus musculus	152-160
15240753-8	2004	The constitutive caspase-1 and IL-1beta processing reactions in THP-1 lysates were insensitive to pharmacological blockade by the tyrphostin, AG126, and the phospholipase A2 inhibitor bromoenol lactone (BEL); contrarily, the same processing reactions were inhibited in lysates from Bac1 cells pretreated with either AG126 or BEL.	AG 127	316-321	interleukin 1 beta	Mus musculus	31-39
15473662-2	2004	Stylopine per se had no cytotoxic effect in unstimulated RAW 264.7 cells, but concentration-dependently reduced nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation.	stylopine	0-9	interleukin 1 beta	Mus musculus	200-217
15473662-2	2004	Stylopine per se had no cytotoxic effect in unstimulated RAW 264.7 cells, but concentration-dependently reduced nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and the IL-6 production and cyclooxygenase-2 (COX-2) activity caused by the LPS stimulation.	stylopine	0-9	interleukin 1 beta	Mus musculus	219-227
15337842-6	2004	In additional experiments, tetrathiomolybdate therapy reversed the elevated serum transaminase levels despite continued concanavalin A injections, with nearly significant serum interleukin-1beta inhibition.	tetrathiomolybdate	27-45	interleukin 1 beta	Mus musculus	177-194
15326138-8	2004	Corneal protein levels for IL-1beta and MIP-2 also were reduced in mice treated with the ICE inhibitor versus placebo and in ICE inhibitor and ciprofloxacin versus ciprofloxacin and placebo-treated mice.	Ciprofloxacin	143-156	interleukin 1 beta	Mus musculus	27-35
15302781-6	2004	We demonstrated that stimulation of wild-type cardiac fibroblasts by isoproterenol markedly increased the production of the interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokines.	Isoproterenol	69-82	interleukin 1 beta	Mus musculus	139-156
15347384-13	2004	Individually, SP600125 and PD98059, but not SB203580, could partly reverse the reduction induced by IL-1beta.	pyrazolanthrone	14-22	interleukin 1 beta	Mus musculus	100-108
15347384-13	2004	Individually, SP600125 and PD98059, but not SB203580, could partly reverse the reduction induced by IL-1beta.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	27-34	interleukin 1 beta	Mus musculus	100-108
15353992-14	2004	A cytokine cocktail of IL-1beta, TNFalpha, and IFNgamma synergistically enhanced nitrite production.	Nitrites	81-88	interleukin 1 beta	Mus musculus	23-31
15353992-19	2004	The pro-inflammatory cytokines, IL-1beta, TNFalpha, and IFNgamma, synergistically induce nitrite production, which was abrogated by treatment with the nitric oxide synthase inhibitor, AG.	Nitrites	89-96	interleukin 1 beta	Mus musculus	32-40
15294346-2	2004	In the present study we investigated the ability of macrophages from mice exposed to isobutyl nitrite to produce the inflammatory cytokine IL-1beta, upon stimulation with IFN-gamma and LPS.	isobutyl nitrite	85-101	interleukin 1 beta	Mus musculus	139-147
15302781-4	2004	The isoproterenol-induced hypertrophy was associated with an increase in the plasma levels of interleukin-1beta and tumor necrosis factor-alpha but not interleukin-6.	Isoproterenol	4-17	interleukin 1 beta	Mus musculus	94-143
15302781-9	2004	CONCLUSIONS: Our results demonstrate for the first time that 5-HT2B receptors are essential for isoproterenol-induced cardiac hypertrophy, which involves the regulation of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by cardiac fibroblasts.	Isoproterenol	96-109	interleukin 1 beta	Mus musculus	187-204
15387956-13	2004	Intrapancreatic TNF-alpha, IL-1beta, ICAM-1 and E-selectin mRNA levels were reduced in OXPAPC-treated group.	oxpapc	87-93	interleukin 1 beta	Mus musculus	27-35
15242550-3	2004	Injection of carrageenan into the pleural cavity of mice induced an acute inflammatory response characterized by fluid accumulation in the pleural cavity that contained a large number of neutrophils, as well as an increased production of tumor necrosis factor-alpha and interleukin-1beta.	Carrageenan	13-24	interleukin 1 beta	Mus musculus	270-287
15238606-7	2004	Aspirin and 15-epi-lipoxin A(4) were shown to inhibit leukocyte trafficking in an NO-dependent manner using intravital microscopy on IL-1beta-stimulated mouse mesentery.	Aspirin	0-7	interleukin 1 beta	Mus musculus	133-141
15270842-7	2004	Phorbol myristate acetate (PMA)-stimulated superoxide production by zymosan-induced peritoneal neutrophils and the levels of zymosan-induced tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta in peritoneal exudate fluids were also reduced in the diabetic mice.	Zymosan	125-132	interleukin 1 beta	Mus musculus	180-202
15240711-5	2004	IL-1beta, which also lacks a secretory signal peptide, may be released by ATP stimulation of the P2X(7)R.	Adenosine Triphosphate	74-77	interleukin 1 beta	Mus musculus	0-8
15273098-10	2004	Cytokine concentrations in BAL samples were reduced in mice that received cethromycin, and the differences were statistically significant for 7 of the 10 cytokines measured (TNF-alpha, IFN-gamma, IL-1beta, IL-8, IL-12, MCP-1, and MIP-1alpha) on day 4 (P &lt; 0.05).	cethromycin	74-85	interleukin 1 beta	Mus musculus	196-204
15305025-8	2004	Moreover, TAS-3-124 inhibited the production of proinflammatory cytokines including interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and IL-6 but not T cell derived cytokines in mice.	6-acetoamido-1-acetyl-1-indazole	10-19	interleukin 1 beta	Mus musculus	84-106
15270842-7	2004	Phorbol myristate acetate (PMA)-stimulated superoxide production by zymosan-induced peritoneal neutrophils and the levels of zymosan-induced tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta in peritoneal exudate fluids were also reduced in the diabetic mice.	Tetradecanoylphorbol Acetate	0-25	interleukin 1 beta	Mus musculus	180-202
15270842-7	2004	Phorbol myristate acetate (PMA)-stimulated superoxide production by zymosan-induced peritoneal neutrophils and the levels of zymosan-induced tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta in peritoneal exudate fluids were also reduced in the diabetic mice.	Tetradecanoylphorbol Acetate	27-30	interleukin 1 beta	Mus musculus	180-202
15387364-7	2004	A single injection of AdvmuIL-10 led to a marked reduction in both stool markers of inflammation (IL-1beta, IL-6, and TNFRII) and serum IL-6.	advmuil-10	22-32	interleukin 1 beta	Mus musculus	98-106
15266025-4	2004	Addition of exogenous PGE(2) to NHTBE cultures also increased MUC5AC production and IL-1beta-induced Muc5ac hypersecretion in tracheas from wild-type but not from COX-2-/- mice.	Prostaglandins E	22-25	interleukin 1 beta	Mus musculus	84-92
15238606-7	2004	Aspirin and 15-epi-lipoxin A(4) were shown to inhibit leukocyte trafficking in an NO-dependent manner using intravital microscopy on IL-1beta-stimulated mouse mesentery.	15-epi-lipoxin a	12-28	interleukin 1 beta	Mus musculus	133-141
15033982-5	2004	In contrast, an IL-1beta-induced phosphorylation of serine residues in NF-kappaB p65 subunit was observed in EMT-6J, but not in EMT-6H, cells.	Serine	52-58	interleukin 1 beta	Mus musculus	16-24
15187154-9	2004	Instead, IL-1beta inhibited the ability of IGF-I to phosphorylate tyrosine residues on both of its downstream docking proteins, insulin receptor substrate 1 and insulin receptor substrate 2.	Tyrosine	66-74	interleukin 1 beta	Mus musculus	9-17
15033982-6	2004	This IL-1beta-induced phosphorylation of p65 was specifically prevented by pretreatment of EMT-6J cells with the casein kinase II inhibitor DRB.	Dichlororibofuranosylbenzimidazole	140-143	interleukin 1 beta	Mus musculus	5-13
14754758-3	2004	IL-1beta expression, assessed by gene microarray, was increased 2-fold 4 h after O(3) exposure, and returned to baseline levels by 24 h. Levels of IL-1beta in lung homogenates were also increased 8 h after O(3) exposure.	Ozone	81-85	interleukin 1 beta	Mus musculus	0-8
14754758-3	2004	IL-1beta expression, assessed by gene microarray, was increased 2-fold 4 h after O(3) exposure, and returned to baseline levels by 24 h. Levels of IL-1beta in lung homogenates were also increased 8 h after O(3) exposure.	Ozone	81-85	interleukin 1 beta	Mus musculus	147-155
14754758-3	2004	IL-1beta expression, assessed by gene microarray, was increased 2-fold 4 h after O(3) exposure, and returned to baseline levels by 24 h. Levels of IL-1beta in lung homogenates were also increased 8 h after O(3) exposure.	Ozone	206-210	interleukin 1 beta	Mus musculus	0-8
14754758-3	2004	IL-1beta expression, assessed by gene microarray, was increased 2-fold 4 h after O(3) exposure, and returned to baseline levels by 24 h. Levels of IL-1beta in lung homogenates were also increased 8 h after O(3) exposure.	Ozone	206-210	interleukin 1 beta	Mus musculus	147-155
15135319-3	2004	However, the issue of whether PGE2 regulates the expression of IL-1beta in mouse osteoblasts has not been resolved.	Dinoprostone	30-34	interleukin 1 beta	Mus musculus	63-71
15187521-10	2004	MEASUREMENTS AND MAIN RESULTS: At 18 hrs after zymosan administration, we found a significant increase of peritoneal exudates, leukocyte infiltration in peritoneal cavity as well as an infiltration of neutrophils in lung and ileum tissues and subsequent lipid peroxidation, and increased production of plasma tumor necrosis factor-alpha and interleukin-1 beta.	Zymosan	47-54	interleukin 1 beta	Mus musculus	341-359
16219171-1	2004	The work is to explore the relationship between the levels of cytokines (IL-1beta and IL-6) in C57BL/6J mice treated with MPTP and brain lateralization.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	122-126	interleukin 1 beta	Mus musculus	73-81
15158982-1	2004	Scopoletin (1-50 microg/ml) inhibited the release of PGE2, TNF-alpha, IL-1beta and IL-6 and suppressed the expression of COX-2 in a concentration-dependent manner.	Scopoletin	0-10	interleukin 1 beta	Mus musculus	70-78
15135319-0	2004	PGE2 induces IL-1beta gene expression in mouse osteoblasts through a cAMP-PKA signaling pathway.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	13-21
15135319-0	2004	PGE2 induces IL-1beta gene expression in mouse osteoblasts through a cAMP-PKA signaling pathway.	Cyclic AMP	69-73	interleukin 1 beta	Mus musculus	13-21
15135319-4	2004	In this work, we demonstrate that PGE2 is a potent inducer of IL-1beta production by fetal osteoblasts and show that PGE2 stimulates the activity of the IL-1beta promoter in osteoblasts, suggesting that PGE2 controls IL-1beta gene expression at least at the transcriptional level.	Dinoprostone	34-38	interleukin 1 beta	Mus musculus	62-70
15135319-4	2004	In this work, we demonstrate that PGE2 is a potent inducer of IL-1beta production by fetal osteoblasts and show that PGE2 stimulates the activity of the IL-1beta promoter in osteoblasts, suggesting that PGE2 controls IL-1beta gene expression at least at the transcriptional level.	Dinoprostone	117-121	interleukin 1 beta	Mus musculus	153-161
15135319-4	2004	In this work, we demonstrate that PGE2 is a potent inducer of IL-1beta production by fetal osteoblasts and show that PGE2 stimulates the activity of the IL-1beta promoter in osteoblasts, suggesting that PGE2 controls IL-1beta gene expression at least at the transcriptional level.	Dinoprostone	117-121	interleukin 1 beta	Mus musculus	153-161
15135319-4	2004	In this work, we demonstrate that PGE2 is a potent inducer of IL-1beta production by fetal osteoblasts and show that PGE2 stimulates the activity of the IL-1beta promoter in osteoblasts, suggesting that PGE2 controls IL-1beta gene expression at least at the transcriptional level.	Dinoprostone	117-121	interleukin 1 beta	Mus musculus	153-161
15135319-4	2004	In this work, we demonstrate that PGE2 is a potent inducer of IL-1beta production by fetal osteoblasts and show that PGE2 stimulates the activity of the IL-1beta promoter in osteoblasts, suggesting that PGE2 controls IL-1beta gene expression at least at the transcriptional level.	Dinoprostone	117-121	interleukin 1 beta	Mus musculus	153-161
15135319-5	2004	PGE2 was found to induce IL-1beta mRNA expression in the cells within 4 h and the level of expression was maintained for 36 h. A dose-related increase in IL-1beta production was found with 0.1-2.0 microM PGE2.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	25-33
15135319-5	2004	PGE2 was found to induce IL-1beta mRNA expression in the cells within 4 h and the level of expression was maintained for 36 h. A dose-related increase in IL-1beta production was found with 0.1-2.0 microM PGE2.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	154-162
15135319-5	2004	PGE2 was found to induce IL-1beta mRNA expression in the cells within 4 h and the level of expression was maintained for 36 h. A dose-related increase in IL-1beta production was found with 0.1-2.0 microM PGE2.	Dinoprostone	204-208	interleukin 1 beta	Mus musculus	25-33
15135319-5	2004	PGE2 was found to induce IL-1beta mRNA expression in the cells within 4 h and the level of expression was maintained for 36 h. A dose-related increase in IL-1beta production was found with 0.1-2.0 microM PGE2.	Dinoprostone	204-208	interleukin 1 beta	Mus musculus	154-162
15135319-7	2004	The role of cAMP activation in PGE2-mediated IL-1beta production was examined by the effects of forskolin, an adenylyl cyclase (AC) activator and dideoxyadenosine (DDA), an AC inhibitor.	Cyclic AMP	12-16	interleukin 1 beta	Mus musculus	45-53
15135319-7	2004	The role of cAMP activation in PGE2-mediated IL-1beta production was examined by the effects of forskolin, an adenylyl cyclase (AC) activator and dideoxyadenosine (DDA), an AC inhibitor.	Dinoprostone	31-35	interleukin 1 beta	Mus musculus	45-53
15135319-8	2004	Forskolin enhanced and DDA blocked the production of IL-1beta by PGE2.	Colforsin	0-9	interleukin 1 beta	Mus musculus	53-61
15135319-8	2004	Forskolin enhanced and DDA blocked the production of IL-1beta by PGE2.	Dideoxyadenosine	23-26	interleukin 1 beta	Mus musculus	53-61
15135319-8	2004	Forskolin enhanced and DDA blocked the production of IL-1beta by PGE2.	Dinoprostone	65-69	interleukin 1 beta	Mus musculus	53-61
15135319-9	2004	In addition, PGE2-mediated IL-1beta induction was completely inhibited by the cAMP antagonist, Rp-cAMP, and protein kinase A (PKA) inhibitors of KT5720 and H89.	Dinoprostone	13-17	interleukin 1 beta	Mus musculus	27-35
15135319-9	2004	In addition, PGE2-mediated IL-1beta induction was completely inhibited by the cAMP antagonist, Rp-cAMP, and protein kinase A (PKA) inhibitors of KT5720 and H89.	Cyclic AMP	78-82	interleukin 1 beta	Mus musculus	27-35
15135319-9	2004	In addition, PGE2-mediated IL-1beta induction was completely inhibited by the cAMP antagonist, Rp-cAMP, and protein kinase A (PKA) inhibitors of KT5720 and H89.	Cyclic AMP	98-102	interleukin 1 beta	Mus musculus	27-35
15135319-10	2004	The PGE2-induced production of IL-1beta was also blocked by the PKA inhibitor PKI14-22.	Dinoprostone	4-8	interleukin 1 beta	Mus musculus	31-39
15135319-12	2004	Among the potential agonists, forskolin was a potent inducer of IL-1beta expression, while phorbol myristate acetate and serum had little effect.	Colforsin	30-39	interleukin 1 beta	Mus musculus	64-72
15135319-13	2004	These findings indicate that PGE2 involves the cAMP-PKA signaling pathway in regulating IL-1beta gene expression in osteoblasts.	Dinoprostone	29-33	interleukin 1 beta	Mus musculus	88-96
15135319-13	2004	These findings indicate that PGE2 involves the cAMP-PKA signaling pathway in regulating IL-1beta gene expression in osteoblasts.	Cyclic AMP	47-51	interleukin 1 beta	Mus musculus	88-96
15335168-2	2004	To study the molecular mechanisms of immunomodulatory effects of Interleukin-1 and glucocorticoid hormones, a search for changes in activity of neutral sphingomyelinase: the main marker of initiation of Interleukin-1beta signal transduction via the sphingomyelin pathway in target cells, was accomplished.	Sphingomyelins	152-165	interleukin 1 beta	Mus musculus	203-220
15154872-11	2004	The prolonged exposure of TVMF depressed the augmentation effects, which was caused by the depressed IL-2 receptor expression although both IL1-beta and IL-2 productions were not affected.	tvmf	26-30	interleukin 1 beta	Mus musculus	140-148
15075209-4	2004	In contrast, brief (5 min) treatment of intact macrophages with extracellular ATP (as an activator of the P2X(7) receptor) or nigericin before cell lysis markedly accelerated the in vitro processing of caspase-1 and IL-1beta.	Adenosine Triphosphate	78-81	interleukin 1 beta	Mus musculus	216-224
15135806-3	2004	In this study we show that mast cells stimulated by IL-9 and ionomycin or IL-9 and antigen-specific IgE/antigen express several cytokines at mRNA level, among them are IL-5, IL-4, IL-10, IL-9, IL-13, IL-1beta, IL-1Ra, IL-6 and MIF.	Ionomycin	61-70	interleukin 1 beta	Mus musculus	200-208
15135806-4	2004	Furthermore, both IL-9 and ionomycin are needed for the production of these cytokines in great quantities, which is mediated through the production of IL-1beta.	Ionomycin	27-36	interleukin 1 beta	Mus musculus	151-159
15196696-5	2004	We found that iNOS -/- islets responded with a reduced PGE(2) formation following IL-1beta or (IL-1beta + IFN-gamma) treatment compared to wild-type (wt) islets, while COX-2 mRNA or protein content were unchanged.	Prostaglandins E	55-58	interleukin 1 beta	Mus musculus	82-90
15075209-4	2004	In contrast, brief (5 min) treatment of intact macrophages with extracellular ATP (as an activator of the P2X(7) receptor) or nigericin before cell lysis markedly accelerated the in vitro processing of caspase-1 and IL-1beta.	Nigericin	126-135	interleukin 1 beta	Mus musculus	216-224
14975584-2	2004	To understand the consequences of its presence in brain, we carried out intraparenchymal IL-1beta injections and found significant increases in prostaglandin (PG)E2, a critical factor in inflammatory and physiological processes.	Dinoprostone	144-164	interleukin 1 beta	Mus musculus	89-97
15048855-3	2004	Therefore, interleukin-1beta (IL-1beta), which contributes to stroke-induced brain injury and activates p38/SAPK2, and hyperosmolarity induced by sorbitol, a potent stimulus of p38/SAPK2 in non-neuronal cells, were used to investigate a possible involvement of p38/SAPK2 in GJC modulation in mouse cultured astrocytes.	Sorbitol	146-154	interleukin 1 beta	Mus musculus	30-38
15048855-8	2004	The pharmacological agent SB203580 specifically blocked p38/SAPK2 activation, cytoplasmic translocation and reversed the IL-1beta and sorbitol-induced inhibition of GJC.	SB 203580	26-34	interleukin 1 beta	Mus musculus	121-129
15195698-10	2004	Western blot analysis confirmed that SB203580 inhibited p38 MAP kinase, in response to IL-1beta in a dose dependent manner in MC3T3-E1 cells.	SB 203580	37-45	interleukin 1 beta	Mus musculus	87-95
15194409-0	2004	Cobalt-Protoporphyrin treatment renders islets tolerant to interleukin-1 beta suppression.	cobaltiprotoporphyrin	0-21	interleukin 1 beta	Mus musculus	59-77
15194409-1	2004	This study examined whether treating donor mice with a single dose of cobalt protoporphyrin (CoPP) induced heme oxygenase-1 (HO-1) and protected islet cells from interleukin-1 beta (IL-1 beta) suppression.	cobaltiprotoporphyrin	70-91	interleukin 1 beta	Mus musculus	162-180
15194409-1	2004	This study examined whether treating donor mice with a single dose of cobalt protoporphyrin (CoPP) induced heme oxygenase-1 (HO-1) and protected islet cells from interleukin-1 beta (IL-1 beta) suppression.	cobaltiprotoporphyrin	70-91	interleukin 1 beta	Mus musculus	182-191
15194409-1	2004	This study examined whether treating donor mice with a single dose of cobalt protoporphyrin (CoPP) induced heme oxygenase-1 (HO-1) and protected islet cells from interleukin-1 beta (IL-1 beta) suppression.	cobaltiprotoporphyrin	93-97	interleukin 1 beta	Mus musculus	162-180
15194409-1	2004	This study examined whether treating donor mice with a single dose of cobalt protoporphyrin (CoPP) induced heme oxygenase-1 (HO-1) and protected islet cells from interleukin-1 beta (IL-1 beta) suppression.	cobaltiprotoporphyrin	93-97	interleukin 1 beta	Mus musculus	182-191
15194409-5	2004	Following a 21-hour incubation with IL-1 beta, CoPP islets secreted significantly more insulin upon glucose stimulation and preserved significantly more IC than control islets.	Glucose	100-107	interleukin 1 beta	Mus musculus	36-45
15194409-6	2004	After 65-hour incubation with IL-1 beta, CoPP islets secreted significantly less insulin upon glucose stimulation than control islets and preserved significantly less IC compared to islets incubated without IL-1 beta.	Glucose	94-101	interleukin 1 beta	Mus musculus	30-39
15194409-7	2004	In conclusion, treatment with cobalt-protoporphyrin to induce heme oxygenase-1 protects islets against the suppressive effects of IL-1 beta.	cobaltiprotoporphyrin	30-51	interleukin 1 beta	Mus musculus	130-139
15041747-4	2004	Here, we demonstrate an additional mechanism whereby a significant reduction of proinflammatory gene expression such as IL-1beta, tumor necrosis factor alpha, and inducible nitricoxide synthase in PARP-1(-/-) glial cells is linked to defective inflammatory stimuli-induced p38MAPK-mediated phosphorylation of ATF-2 and cAMP-response element-binding protein and phosphorylation of NF-kappaB p65.	Cyclic AMP	319-323	interleukin 1 beta	Mus musculus	120-128
15034066-6	2004	Quantification of inflammatory mediator levels in homogenates of zymosan-stimulated tissues indicated reductions in levels of IL-1beta, KC, and macrophage inflammatory protein-1alpha in NE(-/-) mice.	Zymosan	65-72	interleukin 1 beta	Mus musculus	126-134
15104118-4	2004	This study investigated the effects of o,p"-DDT on the production of nitric oxide (NO) and proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) and analyzed the molecular mechanism in mouse macrophages.	o,p'-DDT	39-47	interleukin 1 beta	Mus musculus	118-126
15036463-3	2004	The present study examined the effect of ethanol extract of propolis (EEP) and selected flavone derivatives (chrysin, galangin, kaempferol and quercetin) on interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) gene expression in lipopolysaccharide (LPS)-induced J774A.1 macrophages.	Ethanol	41-48	interleukin 1 beta	Mus musculus	157-174
15036463-3	2004	The present study examined the effect of ethanol extract of propolis (EEP) and selected flavone derivatives (chrysin, galangin, kaempferol and quercetin) on interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) gene expression in lipopolysaccharide (LPS)-induced J774A.1 macrophages.	Ethanol	41-48	interleukin 1 beta	Mus musculus	176-184
15036463-3	2004	The present study examined the effect of ethanol extract of propolis (EEP) and selected flavone derivatives (chrysin, galangin, kaempferol and quercetin) on interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) gene expression in lipopolysaccharide (LPS)-induced J774A.1 macrophages.	flavone	88-95	interleukin 1 beta	Mus musculus	157-174
15036463-3	2004	The present study examined the effect of ethanol extract of propolis (EEP) and selected flavone derivatives (chrysin, galangin, kaempferol and quercetin) on interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) gene expression in lipopolysaccharide (LPS)-induced J774A.1 macrophages.	flavone	88-95	interleukin 1 beta	Mus musculus	176-184
15036463-3	2004	The present study examined the effect of ethanol extract of propolis (EEP) and selected flavone derivatives (chrysin, galangin, kaempferol and quercetin) on interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) gene expression in lipopolysaccharide (LPS)-induced J774A.1 macrophages.	kaempferol	128-138	interleukin 1 beta	Mus musculus	157-174
15180311-4	2004	Wogonin inhibited ear edema (19.4-22.6%) at doses of 50-200 microg/ear and down-regulated interleukin-1beta induction (23.1%) at 200 microg/ear in phenol-induced simple irritation.	Phenol	147-153	interleukin 1 beta	Mus musculus	90-107
14726497-1	2004	Pentraxin 3 (PTX3) is a tumor necrosis factor and interleukin-1beta-stimulated gene that encodes a long PTX with proinflammatory activity.	ptx	13-16	interleukin 1 beta	Mus musculus	50-67
15124865-5	2004	We found that both in naive and compromised mice, AMB treatment caused significantly greater production of the pro-inflammatory cytokines tumour necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) than was seen in animals treated with AMB-IL or with another lipid AMB formulation, AmBisome.	Amphotericin B	50-53	interleukin 1 beta	Mus musculus	183-201
15124865-5	2004	We found that both in naive and compromised mice, AMB treatment caused significantly greater production of the pro-inflammatory cytokines tumour necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1beta) than was seen in animals treated with AMB-IL or with another lipid AMB formulation, AmBisome.	Amphotericin B	50-53	interleukin 1 beta	Mus musculus	203-211
15003335-8	2004	The results demonstrated that NO production, mRNA levels of iNOS, IL-1beta, TNF-alpha were down regulated by MC-LR dose-dependently and mRNA levels of GM-CSF and IFN-gamma were also decreased but in dose-independent manner.	cyanoginosin LR	109-114	interleukin 1 beta	Mus musculus	66-74
15036463-3	2004	The present study examined the effect of ethanol extract of propolis (EEP) and selected flavone derivatives (chrysin, galangin, kaempferol and quercetin) on interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) gene expression in lipopolysaccharide (LPS)-induced J774A.1 macrophages.	Quercetin	143-152	interleukin 1 beta	Mus musculus	157-174
15036463-3	2004	The present study examined the effect of ethanol extract of propolis (EEP) and selected flavone derivatives (chrysin, galangin, kaempferol and quercetin) on interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) gene expression in lipopolysaccharide (LPS)-induced J774A.1 macrophages.	Quercetin	143-152	interleukin 1 beta	Mus musculus	176-184
15030578-0	2004	Involvement of interleukin-1beta in systemic morphine effects on paw oedema in a mouse model of acute inflammation.	Morphine	45-53	interleukin 1 beta	Mus musculus	15-32
14962057-7	2004	This protective effect seems to be due to the increase in the production of interleukin-1beta (IL-1beta), as 100% of the infected mice treated with melatonin die when IL-1beta is blocked with antimurine IL-1beta antibodies.	Melatonin	148-157	interleukin 1 beta	Mus musculus	76-93
14962057-7	2004	This protective effect seems to be due to the increase in the production of interleukin-1beta (IL-1beta), as 100% of the infected mice treated with melatonin die when IL-1beta is blocked with antimurine IL-1beta antibodies.	Melatonin	148-157	interleukin 1 beta	Mus musculus	95-103
14962057-7	2004	This protective effect seems to be due to the increase in the production of interleukin-1beta (IL-1beta), as 100% of the infected mice treated with melatonin die when IL-1beta is blocked with antimurine IL-1beta antibodies.	Melatonin	148-157	interleukin 1 beta	Mus musculus	167-175
14962057-7	2004	This protective effect seems to be due to the increase in the production of interleukin-1beta (IL-1beta), as 100% of the infected mice treated with melatonin die when IL-1beta is blocked with antimurine IL-1beta antibodies.	Melatonin	148-157	interleukin 1 beta	Mus musculus	167-175
15030578-6	2004	Measuring the serum levels of interleukin-1beta revealed that increases in serum levels of this cytokine were involved in morphine anti-inflammatory effects.	Morphine	122-130	interleukin 1 beta	Mus musculus	30-47
15030578-7	2004	Pretreatment with naloxone decreased interleukin-1beta serum levels near to those of control group.	Naloxone	18-26	interleukin 1 beta	Mus musculus	37-54
14742866-8	2004	Increased leukocyte rolling and adhesion in IL-1beta-treated mice was also inhibited by BAY 41-2272.	3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine	88-99	interleukin 1 beta	Mus musculus	44-52
15036626-5	2004	Treatment with H89, a specific inhibitor of protein kinase A (PKA), revealed that an enhancement in the IL-10 and IL-1beta levels by dbcAMP or forskolin totally depends on the PKA pathway, while changes in the other cytokines and iNOS are independent or only partially dependent on the PKA pathway.	Colforsin	143-152	interleukin 1 beta	Mus musculus	114-122
15036626-4	2004	DbcAMP increased the IL-1beta level without affecting either the IL-6 or iNOS expression, whereas forskolin repressed the IL-6 and iNOS expression level without affecting IL-1beta in the LPS-stimulated microglia.	Bucladesine	0-6	interleukin 1 beta	Mus musculus	21-29
15036626-5	2004	Treatment with H89, a specific inhibitor of protein kinase A (PKA), revealed that an enhancement in the IL-10 and IL-1beta levels by dbcAMP or forskolin totally depends on the PKA pathway, while changes in the other cytokines and iNOS are independent or only partially dependent on the PKA pathway.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	15-18	interleukin 1 beta	Mus musculus	114-122
15036626-5	2004	Treatment with H89, a specific inhibitor of protein kinase A (PKA), revealed that an enhancement in the IL-10 and IL-1beta levels by dbcAMP or forskolin totally depends on the PKA pathway, while changes in the other cytokines and iNOS are independent or only partially dependent on the PKA pathway.	Bucladesine	133-139	interleukin 1 beta	Mus musculus	114-122
14981311-0	2004	Suppressive effects of natural and synthetic agents on dextran sulfate sodium-induced interleukin-1beta release from murine peritoneal macrophages.	Dextran Sulfate	55-77	interleukin 1 beta	Mus musculus	86-103
14600029-8	2004	In addition, A1WT mice pretreated with DPCPX or CCPA showed significantly increased or reduced markers of renal inflammation, respectively (renal myeloperoxidase activity, renal tubular neutrophil infiltration, ICAM-1, TNF-alpha, and IL-1beta mRNA expression), while demonstrating no differences in indicators of apoptosis.	1,3-dipropyl-8-cyclopentylxanthine	39-44	interleukin 1 beta	Mus musculus	234-242
14600029-8	2004	In addition, A1WT mice pretreated with DPCPX or CCPA showed significantly increased or reduced markers of renal inflammation, respectively (renal myeloperoxidase activity, renal tubular neutrophil infiltration, ICAM-1, TNF-alpha, and IL-1beta mRNA expression), while demonstrating no differences in indicators of apoptosis.	2-chloro-N(6)cyclopentyladenosine	48-52	interleukin 1 beta	Mus musculus	234-242
14981311-2	2004	We examined the suppressive effects of a total of 39 synthetic or natural compounds on dextran sulfate sodium-induced IL-1beta production in murine peritoneal macrophages.	Dextran Sulfate	87-109	interleukin 1 beta	Mus musculus	118-126
14981311-3	2004	Several compounds, including alpha-tocopherol, gallic acid, (-)-catechin and rutin, were found to be highly effective for attenuating IL-1beta production, suggesting that they would be useful for anti-inflammatory application.	alpha-Tocopherol	29-45	interleukin 1 beta	Mus musculus	134-142
14981311-3	2004	Several compounds, including alpha-tocopherol, gallic acid, (-)-catechin and rutin, were found to be highly effective for attenuating IL-1beta production, suggesting that they would be useful for anti-inflammatory application.	Gallic Acid	47-58	interleukin 1 beta	Mus musculus	134-142
14981311-3	2004	Several compounds, including alpha-tocopherol, gallic acid, (-)-catechin and rutin, were found to be highly effective for attenuating IL-1beta production, suggesting that they would be useful for anti-inflammatory application.	Catechin	60-72	interleukin 1 beta	Mus musculus	134-142
14981311-3	2004	Several compounds, including alpha-tocopherol, gallic acid, (-)-catechin and rutin, were found to be highly effective for attenuating IL-1beta production, suggesting that they would be useful for anti-inflammatory application.	Rutin	77-82	interleukin 1 beta	Mus musculus	134-142
15145076-0	2004	ATP-induced inhibition of gap junctional communication is enhanced by interleukin-1 beta treatment in cultured astrocytes.	Adenosine Triphosphate	0-3	interleukin 1 beta	Mus musculus	70-88
14769824-3	2004	IL-1beta enhanced expression of various prostanoids and this expression was blocked by COX2 selective inhibitors.	Prostaglandins	40-51	interleukin 1 beta	Mus musculus	0-8
14769824-8	2004	This is the first report that COX2 and some prostanoids play a key role in IL-1beta-induced angiogenesis.	Prostaglandins	44-55	interleukin 1 beta	Mus musculus	75-83
14670622-0	2004	2-Acetylaminofluorene inhibits interleukin-1beta production in LPS-stimulated macrophages by blocking NF-kappaB/Rel activation.	2-Acetylaminofluorene	0-21	interleukin 1 beta	Mus musculus	31-48
14670622-1	2004	In the present study, we demonstrate the inhibitory effect of 2-acetylaminofluorene (AAF) on interleukin-1beta (IL-1beta) gene expression in lipopolysaccharide (LPS)-stimulated macrophages.	2-Acetylaminofluorene	62-83	interleukin 1 beta	Mus musculus	93-110
14670622-1	2004	In the present study, we demonstrate the inhibitory effect of 2-acetylaminofluorene (AAF) on interleukin-1beta (IL-1beta) gene expression in lipopolysaccharide (LPS)-stimulated macrophages.	2-Acetylaminofluorene	62-83	interleukin 1 beta	Mus musculus	112-120
14670622-1	2004	In the present study, we demonstrate the inhibitory effect of 2-acetylaminofluorene (AAF) on interleukin-1beta (IL-1beta) gene expression in lipopolysaccharide (LPS)-stimulated macrophages.	2-Acetylaminofluorene	85-88	interleukin 1 beta	Mus musculus	93-110
14670622-1	2004	In the present study, we demonstrate the inhibitory effect of 2-acetylaminofluorene (AAF) on interleukin-1beta (IL-1beta) gene expression in lipopolysaccharide (LPS)-stimulated macrophages.	2-Acetylaminofluorene	85-88	interleukin 1 beta	Mus musculus	112-120
14672714-0	2004	Costunolide inhibits interleukin-1beta expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells.	costunolide	0-11	interleukin 1 beta	Mus musculus	21-38
14672714-2	2004	Here, we demonstrated the inhibitory effect of costunolide on the protein and mRNA expression of interleukin-1beta (IL-1beta) in LPS-stimulated RAW 264.7 cells.	costunolide	47-58	interleukin 1 beta	Mus musculus	97-114
14672714-2	2004	Here, we demonstrated the inhibitory effect of costunolide on the protein and mRNA expression of interleukin-1beta (IL-1beta) in LPS-stimulated RAW 264.7 cells.	costunolide	47-58	interleukin 1 beta	Mus musculus	116-124
14672714-3	2004	We also showed that costunolide suppressed the transcriptional activity of the IL-1beta promoter.	costunolide	20-31	interleukin 1 beta	Mus musculus	79-87
14672714-6	2004	Additionally, specific inhibitors of SAPK/JNK and p38 MAP kinase, SP600125 and SB203580, also suppressed LPS-induced increase in IL-1beta gene expression and AP-1 DNA binding.	pyrazolanthrone	66-74	interleukin 1 beta	Mus musculus	129-137
14672714-6	2004	Additionally, specific inhibitors of SAPK/JNK and p38 MAP kinase, SP600125 and SB203580, also suppressed LPS-induced increase in IL-1beta gene expression and AP-1 DNA binding.	SB 203580	79-87	interleukin 1 beta	Mus musculus	129-137
14672714-7	2004	Taken together, these results demonstrate that costunolide inhibits IL-1beta gene expression by blocking the activation of MAPKs and DNA binding of AP-1 in LPS-stimulated RAW 264.7 cells.	costunolide	47-58	interleukin 1 beta	Mus musculus	68-76
14667940-0	2004	Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1beta and prostaglandin E2 synthesis by silymarin.	Silymarin	123-132	interleukin 1 beta	Mus musculus	71-88
14667940-5	2004	To further investigate the mechanism responsible for anti-septic effect of silymarin, we examined the inhibitory effect of silymarin on interleukin-1beta (IL-1beta) and prostaglandin E2 (PGE2) production in macrophages.	Silymarin	123-132	interleukin 1 beta	Mus musculus	136-153
14667940-5	2004	To further investigate the mechanism responsible for anti-septic effect of silymarin, we examined the inhibitory effect of silymarin on interleukin-1beta (IL-1beta) and prostaglandin E2 (PGE2) production in macrophages.	Silymarin	123-132	interleukin 1 beta	Mus musculus	155-163
14667940-6	2004	Silymarin dose-dependently suppressed the LPS-induced production of IL-1beta and PGE2 in isolated mouse peritoneal macrophages and RAW 264.7 cells.	Silymarin	0-9	interleukin 1 beta	Mus musculus	68-76
14667940-7	2004	Consistent with these results, the mRNA expression of IL-1beta and cyclooxygenase-2 was also completely blocked by silymarin in LPS-stimulated RAW 264.7 cells.	Silymarin	115-124	interleukin 1 beta	Mus musculus	54-62
14667940-9	2004	Taken together, these results demonstrate that silymarin has a protective effect against endotoxin-induced sepsis, and suggest that this is mediated, at least in part, by the inhibitory effect of silymarin on the production of IL-1beta and PGE2.	Silymarin	47-56	interleukin 1 beta	Mus musculus	227-235
14667940-9	2004	Taken together, these results demonstrate that silymarin has a protective effect against endotoxin-induced sepsis, and suggest that this is mediated, at least in part, by the inhibitory effect of silymarin on the production of IL-1beta and PGE2.	Silymarin	196-205	interleukin 1 beta	Mus musculus	227-235
15145076-7	2004	Pretreatment with the pro-inflammatory cytokine interleukin-1beta (10 ng/ml, 24 h), which has no effect by itself on gap junctional communication, increases the inhibitory effect of ATP and astrocytes become sensitive to uridine 5"-triphosphate (UTP).	Adenosine Triphosphate	182-185	interleukin 1 beta	Mus musculus	48-65
15145076-7	2004	Pretreatment with the pro-inflammatory cytokine interleukin-1beta (10 ng/ml, 24 h), which has no effect by itself on gap junctional communication, increases the inhibitory effect of ATP and astrocytes become sensitive to uridine 5"-triphosphate (UTP).	Uridine Triphosphate	221-244	interleukin 1 beta	Mus musculus	48-65
15145076-7	2004	Pretreatment with the pro-inflammatory cytokine interleukin-1beta (10 ng/ml, 24 h), which has no effect by itself on gap junctional communication, increases the inhibitory effect of ATP and astrocytes become sensitive to uridine 5"-triphosphate (UTP).	Uridine Triphosphate	246-249	interleukin 1 beta	Mus musculus	48-65
15145076-8	2004	As indicated by the enhanced expression of P2Y(2) receptor mRNA, P2Y(2) receptors are responsible for the increased responses evoked by ATP and UTP in interleukin-1beta-treated cells.	Adenosine Triphosphate	136-139	interleukin 1 beta	Mus musculus	151-168
15145076-8	2004	As indicated by the enhanced expression of P2Y(2) receptor mRNA, P2Y(2) receptors are responsible for the increased responses evoked by ATP and UTP in interleukin-1beta-treated cells.	Uridine Triphosphate	144-147	interleukin 1 beta	Mus musculus	151-168
12920043-2	2003	In the present study we confirm that Fas signaling induces both phenotypic and functional maturation of murine DCs, and we demonstrate that phenotypic maturation is associated with phosphorylation of extracellular signal-regulated kinase (ERK) 1/2, activation of caspase-1, and secretion of interleukin-beta (IL-1beta).	ammonium ferrous sulfate	37-40	interleukin 1 beta	Mus musculus	309-317
14651966-0	2003	Plasminogen-induced IL-1beta and TNF-alpha production in microglia is regulated by reactive oxygen species.	Reactive Oxygen Species	83-106	interleukin 1 beta	Mus musculus	20-28
14651966-6	2003	Reactive oxygen species (ROS) appeared to play an important role in plasminogen-induced microglial activation, with ROS being generated within 15min of plasminogen treatment, and antioxidants (100 microM trolox and 10mM NAC) reducing IL-1beta and TNF-alpha expression in plasminogen-treated cells.	Reactive Oxygen Species	0-23	interleukin 1 beta	Mus musculus	234-242
12920043-3	2003	Specific inhibition of ERK1/2 diminished Fas ligation-induced caspase-1 activation, IL-1beta secretion, and ensuing up-regulation of developmental markers, whereas treatment with neutralizing anti-IL-1beta antibody abrogated phenotypic and functional maturation, indicating that IL-1beta mediates Fas ligation-induced DC maturation in an autocrine manner.	ammonium ferrous sulfate	41-44	interleukin 1 beta	Mus musculus	197-205
12920043-3	2003	Specific inhibition of ERK1/2 diminished Fas ligation-induced caspase-1 activation, IL-1beta secretion, and ensuing up-regulation of developmental markers, whereas treatment with neutralizing anti-IL-1beta antibody abrogated phenotypic and functional maturation, indicating that IL-1beta mediates Fas ligation-induced DC maturation in an autocrine manner.	ammonium ferrous sulfate	41-44	interleukin 1 beta	Mus musculus	197-205
12920043-3	2003	Specific inhibition of ERK1/2 diminished Fas ligation-induced caspase-1 activation, IL-1beta secretion, and ensuing up-regulation of developmental markers, whereas treatment with neutralizing anti-IL-1beta antibody abrogated phenotypic and functional maturation, indicating that IL-1beta mediates Fas ligation-induced DC maturation in an autocrine manner.	ammonium ferrous sulfate	41-44	interleukin 1 beta	Mus musculus	84-92
14625346-18	2003	IL-1beta is increased early in acetaminophen toxicity and may be important in iNOS induction.	Acetaminophen	31-44	interleukin 1 beta	Mus musculus	0-8
14674008-15	2003	Plasma levels of the proinflammatory cytokines tumor necrosis factor, interleukin-1beta, and interleukin-6 were also significantly reduced by rosiglitazone treatment.	Rosiglitazone	142-155	interleukin 1 beta	Mus musculus	70-87
14662844-4	2003	Cells transfected with secretable IL-1beta (mIL-1beta and ssIL-1beta) were more aggressive than wild-type and mock-transfected tumor cells; ssIL-1beta transfectants even exhibited metastatic tumors in the lungs of mice after i.v.	ssil-1beta	58-68	interleukin 1 beta	Mus musculus	34-42
14662844-4	2003	Cells transfected with secretable IL-1beta (mIL-1beta and ssIL-1beta) were more aggressive than wild-type and mock-transfected tumor cells; ssIL-1beta transfectants even exhibited metastatic tumors in the lungs of mice after i.v.	ssil-1beta	140-150	interleukin 1 beta	Mus musculus	34-42
14662844-4	2003	Cells transfected with secretable IL-1beta (mIL-1beta and ssIL-1beta) were more aggressive than wild-type and mock-transfected tumor cells; ssIL-1beta transfectants even exhibited metastatic tumors in the lungs of mice after i.v.	ssil-1beta	140-150	interleukin 1 beta	Mus musculus	44-53
14723345-2	2003	We postulated that BA modulates the immunomodulatory properties at least two groups of protein mediators of inflammation, interleukin-1beta (IL-1beta) and the tumor necrosis factor-alpha (TNF-alpha) on the basis of the critical role of the monocytes and tissue macrophages in inflammatory and immune responses.	betulinic acid	19-21	interleukin 1 beta	Mus musculus	122-139
14723345-2	2003	We postulated that BA modulates the immunomodulatory properties at least two groups of protein mediators of inflammation, interleukin-1beta (IL-1beta) and the tumor necrosis factor-alpha (TNF-alpha) on the basis of the critical role of the monocytes and tissue macrophages in inflammatory and immune responses.	betulinic acid	19-21	interleukin 1 beta	Mus musculus	141-149
14723345-3	2003	TNF-alpha and IL-1beta were produced by BA in a dose dependent manner at concentration of 0.625 and 10 microg/mL.	betulinic acid	40-42	interleukin 1 beta	Mus musculus	14-22
14679052-9	2003	At days 11 and 14, several intra-islet macrophages with immunolabeling for Fas also coexpressed interleukin-1beta and inducible nitric oxide synthase.	ammonium ferrous sulfate	75-78	interleukin 1 beta	Mus musculus	96-113
12960176-5	2003	Deleterious effects of PA are associated with the secretion of proinflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and the production of nitric oxide, prostaglandin E2, which are predominantly released by macrophage Raw264.7 cells.	Phosphatidic Acids	23-25	interleukin 1 beta	Mus musculus	127-144
14612947-3	2003	IL-1beta also increased tyrosine phosphorylation of PLC-gamma in Src kinase-dependent manner.	Tyrosine	24-32	interleukin 1 beta	Mus musculus	0-8
14612947-4	2003	Pharmacological inhibition of the PLC-PKC cascade by using specific inhibitor for PLC-gamma (U73122) and PKC (GFX) strongly inhibited IL-1beta-induced Erk and Akt activation.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	93-99	interleukin 1 beta	Mus musculus	134-142
14612947-4	2003	Pharmacological inhibition of the PLC-PKC cascade by using specific inhibitor for PLC-gamma (U73122) and PKC (GFX) strongly inhibited IL-1beta-induced Erk and Akt activation.	gfx	110-113	interleukin 1 beta	Mus musculus	134-142
14679069-4	2003	Incubation of MIN6 cells with IL-1beta, IFN-gamma, and TNF-alpha (cytomix) increased production of nitrites, with increased expression of iNOS mRNA.	Nitrites	99-107	interleukin 1 beta	Mus musculus	30-38
14501948-18	2003	DHEA reduces the systemic inflammation, measurable via the proinflammatory cytokines TNF-alpha, IL-1beta, IL-6, and the antiinflammatory cytokine IL-10.	Dehydroepiandrosterone	0-4	interleukin 1 beta	Mus musculus	96-104
14563491-3	2003	Our previous studies indicated that non-antimicrobial chemically modified tetracyclines (CMTs) can dose-dependently inhibit IL-1 beta-induced IL-6 secretion in osteoblastic cells.	Tetracyclines	74-87	interleukin 1 beta	Mus musculus	124-133
14563491-3	2003	Our previous studies indicated that non-antimicrobial chemically modified tetracyclines (CMTs) can dose-dependently inhibit IL-1 beta-induced IL-6 secretion in osteoblastic cells.	cmts	89-93	interleukin 1 beta	Mus musculus	124-133
14550746-8	2003	Acetaminophen-induced expression of MCP-1, IL-1beta, CTGF, and MMP-9 mRNA was also delayed or reduced in TNFR1(-/-) mice relative to wild-type mice.	Acetaminophen	0-13	interleukin 1 beta	Mus musculus	43-51
14728887-12	2003	Yet curcumin could significantly decrease collagen type IV and III in the supernatant of cultured mesangial cells induced by LPS (20.5 +/- 1.00, P &lt; 0.05 and 20.5 +/- 4.12 ng/ml, P &lt; 0.05) and down-regulated the mRNA expression of IL-1 beta and MCP-1 in mesangial cells induced by LPS (P &lt; 0.01).	Curcumin	4-12	interleukin 1 beta	Mus musculus	237-246
14519947-3	2003	Pretreatment with PL 24 h before LPS administration resulted in a significant inhibition of up to 68% of circulating tumor necrosis factor (TNF)-alpha, a moderate reduction of 45% of interleukine (IL)-12 and 23% of IL-1beta, but no significant reduction in IL-6.	Polysaccharides	18-20	interleukin 1 beta	Mus musculus	215-223
12657566-1	2003	Proinflammatry cytokines, tumor necrosis factor-alpha combined with interleukin-1beta, induce excessive production of nitric oxide (NO) and its cytotoxic metabolite peroxynitrite (ONOO-) via inducible nitric oxide synthase (iNOS) in murine osteoblasts.	oxido nitrite	180-185	interleukin 1 beta	Mus musculus	68-85
14551033-6	2003	The expression of cytokines such as IL-1beta, IL-2, IL-6, IL-12 and IFN-gamma in AMG- and L-NAME treated grafts were significantly decreased (P&lt;0.01), whereas IL-10, TNF-alpha and TGF-beta1 were unchanged or enhanced.	NG-Nitroarginine Methyl Ester	90-96	interleukin 1 beta	Mus musculus	36-44
12657566-1	2003	Proinflammatry cytokines, tumor necrosis factor-alpha combined with interleukin-1beta, induce excessive production of nitric oxide (NO) and its cytotoxic metabolite peroxynitrite (ONOO-) via inducible nitric oxide synthase (iNOS) in murine osteoblasts.	Nitric Oxide	118-130	interleukin 1 beta	Mus musculus	68-85
12657566-1	2003	Proinflammatry cytokines, tumor necrosis factor-alpha combined with interleukin-1beta, induce excessive production of nitric oxide (NO) and its cytotoxic metabolite peroxynitrite (ONOO-) via inducible nitric oxide synthase (iNOS) in murine osteoblasts.	Peroxynitrous Acid	165-178	interleukin 1 beta	Mus musculus	68-85
14501948-12	2003	Moreover, DHEA-treated animals demonstrated a reduction in systemic inflammatory effects, as determined by proinflammatory cytokines TNF-alpha, IL-1beta, IL-6, and the antiinflammatory cytokine IL-10.	Dehydroepiandrosterone	10-14	interleukin 1 beta	Mus musculus	144-152
12796490-6	2003	ATP on its own had no effect on the synthesis of pro-IL-1beta, but a co-treatment with lipopolysaccharide and ATP led to the maturation and the release of IL-1beta by Schwann cells.	Adenosine Triphosphate	110-113	interleukin 1 beta	Mus musculus	155-163
12898012-2	2003	Interleukin-1beta (IL-1beta) has been reported to cause suppression of insulin secretion from pancreatic islets via induction of inducible nitric oxide synthase (iNOS) followed by nitric oxide (NO) production.	Nitric Oxide	139-151	interleukin 1 beta	Mus musculus	0-17
12898012-2	2003	Interleukin-1beta (IL-1beta) has been reported to cause suppression of insulin secretion from pancreatic islets via induction of inducible nitric oxide synthase (iNOS) followed by nitric oxide (NO) production.	Nitric Oxide	139-151	interleukin 1 beta	Mus musculus	19-27
12898012-11	2003	While ONO-1714 completely inhibited IL-1beta-induced NO production, it did not reduce expression of islet iNOS mRNA.	7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane	6-14	interleukin 1 beta	Mus musculus	36-44
14501900-14	2003	A combined treatment with NMMA and LPS significantly blocked LPS-induced TNF-alpha and IL-1 beta (p &lt; 0.01), but synergistically enhanced LPS-induced IL-10 (p &lt; 0.05) protein and RNA.	nmma	26-30	interleukin 1 beta	Mus musculus	87-96
14503852-4	2003	Astaxanthin also suppressed the serum levels of NO, PGE2, TNF-alpha, and IL-1beta in LPS-administrated mice, and inhibited NF-kappaB activation as well as iNOS promoter activity in RAW264.7 cells stimulated with LPS.	astaxanthine	0-11	interleukin 1 beta	Mus musculus	73-81
12796490-10	2003	In searching for a link between the P2X7 receptor and the activation of ICE, we found that enhancing potassium efflux from Schwann cells upregulated the production of IL-1beta, while strongly reducing potassium efflux led to opposite effects.	Potassium	101-110	interleukin 1 beta	Mus musculus	167-175
12796490-9	2003	The specific inhibition of ICE by the caspase inhibitor Ac-Tyr-Val-Ala-Asp-aldehyde blocked the maturation of IL-1beta.	L 709049	56-83	interleukin 1 beta	Mus musculus	110-118
19180798-12	2003	Furthermore, treatment of indomethacin and dexamethasone clearly abolished the responses of IL-1alpha and IL-1beta.	Indomethacin	26-38	interleukin 1 beta	Mus musculus	106-114
12660148-5	2003	Using HEK-293 cells engineered to coexpress P2X7 receptors with mature IL-1beta (mIL-1beta), we show that activation of P2X7 receptors results in a rapid secretion of mIL-1beta by a process(es) that is dependent on influx of extracellular Ca2+ and a sustained rise in cytosolic Ca2+.	Einsteinium	40-42	interleukin 1 beta	Mus musculus	167-176
19180798-12	2003	Furthermore, treatment of indomethacin and dexamethasone clearly abolished the responses of IL-1alpha and IL-1beta.	Dexamethasone	43-56	interleukin 1 beta	Mus musculus	106-114
12947309-1	2003	BACKGROUND: Interferon (IFN)-gamma acts synergistically with interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha to activate isoform of nitric oxide synthetase (iNOS) gene expression, induce apoptosis, and impair glucose-stimulated insulin release (GSIR) in pancreatic islets.	Glucose	222-229	interleukin 1 beta	Mus musculus	61-83
12883334-7	2003	Hematein treatment also suppressed the activity of iNOS promoters in RAW264.7 macrophages, and reduced the plasma levels of TNF-alpha and IL-1beta and the production of these cytokines in LPS+IFNgamma-stimulated peritoneal macrophages.	hematein	0-8	interleukin 1 beta	Mus musculus	138-146
14514469-8	2003	The data in the present study also showed that pre-treatment of mice with macrolide antibiotics for 4 weeks significantly suppresses not only production of pro-inflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha, but also inducible nitric oxide synthase mRNA expressions, which are enhanced by LPS injection.	macrolide antibiotics	74-95	interleukin 1 beta	Mus musculus	183-200
12918124-11	2003	While the liver HO-1 expression in TNF KO mice was much lower than that in C57 mice following the same LPS treatment, IL-1beta KO had a slight influence on liver HO-1 expression following LPS treatment.	lps	188-191	interleukin 1 beta	Mus musculus	118-126
12918124-0	2003	TLR4 mediates LPS-induced HO-1 expression in mouse liver: role of TNF-alpha and IL-1beta.	lps	14-17	interleukin 1 beta	Mus musculus	80-88
12918124-14	2003	LPS-induced HO-1 expression is mainly mediated by endogenous TNF-alpha, but only partially by endogenous IL-1beta.	lps	0-3	interleukin 1 beta	Mus musculus	105-113
12831777-3	2003	We examined how the methanol extract of C. pruinosa regulates production of IL-1beta, TNF-alpha, nitric oxide (NO), and prostaglandin E(2) (PGE(2)) in vitro and in vivo.	Methanol	20-28	interleukin 1 beta	Mus musculus	76-84
12637253-4	2003	This was accompanied by a reduction in myeloperoxidase activity, and using semiquantitative RT-PCR, an attenuation of the DNB-induced message for IL-1beta was detected.	2,4-dinitrofluorobenzene sulfonic acid	122-125	interleukin 1 beta	Mus musculus	146-154
12801955-8	2003	In addition, the stool concentration of IL-1beta over the four week experiment was significantly higher in mice treated with saline or Adv0 than in those treated with AdvmuIL-10 (p&lt;0.01).	Sodium Chloride	125-131	interleukin 1 beta	Mus musculus	40-48
12801955-8	2003	In addition, the stool concentration of IL-1beta over the four week experiment was significantly higher in mice treated with saline or Adv0 than in those treated with AdvmuIL-10 (p&lt;0.01).	advmuil-10	167-177	interleukin 1 beta	Mus musculus	40-48
12773775-0	2003	Role of IL-1(beta) in endotoxin potentiation of deoxynivalenol-induced corticosterone response and leukocyte apoptosis in mice.	deoxynivalenol	48-62	interleukin 1 beta	Mus musculus	8-18
12773775-0	2003	Role of IL-1(beta) in endotoxin potentiation of deoxynivalenol-induced corticosterone response and leukocyte apoptosis in mice.	Corticosterone	71-85	interleukin 1 beta	Mus musculus	8-18
12773775-3	2003	The purpose of this study was to test the hypothesis that interleukin-1beta (IL-1beta) plays a central role in corticosterone induction and subsequent leukocyte apoptosis in this model.	Corticosterone	111-125	interleukin 1 beta	Mus musculus	58-75
12773775-3	2003	The purpose of this study was to test the hypothesis that interleukin-1beta (IL-1beta) plays a central role in corticosterone induction and subsequent leukocyte apoptosis in this model.	Corticosterone	111-125	interleukin 1 beta	Mus musculus	77-85
12773775-4	2003	Coexposure to LPS (0.1 mg/kg, ip) plus DON (12.5 mg/kg, po) was found to significantly upregulate splenic IL-1beta mRNA and IL-1beta protein expression in B6C3F1 mice, as compared to treatments with vehicle or either of the toxins alone.	deoxynivalenol	39-42	interleukin 1 beta	Mus musculus	106-114
12773775-4	2003	Coexposure to LPS (0.1 mg/kg, ip) plus DON (12.5 mg/kg, po) was found to significantly upregulate splenic IL-1beta mRNA and IL-1beta protein expression in B6C3F1 mice, as compared to treatments with vehicle or either of the toxins alone.	deoxynivalenol	39-42	interleukin 1 beta	Mus musculus	124-132
12773775-9	2003	Plasma corticosterone levels and thymus and Peyer"s patch apoptosis in IL-1beta-injected mice were significantly higher at 12 h than in control mice.	Corticosterone	7-21	interleukin 1 beta	Mus musculus	71-79
12759141-6	2003	injection of TNF-alpha (100 pg), IL-1 beta (100 pg), IFN-gamma (100 pg), substance P (0.7 microg) or glutamate (20 microg) was dose-dependently diminished by decursinol.	decursin	158-168	interleukin 1 beta	Mus musculus	33-42
12773775-11	2003	Taken together, the results indicate that IL-1beta is an important mediator of LPS plus DON-induced corticosterone and subsequent leukocyte apoptosis and, furthermore, this cytokine possibly acts through an ACTH-independent mechanism.	deoxynivalenol	88-91	interleukin 1 beta	Mus musculus	42-50
12773775-11	2003	Taken together, the results indicate that IL-1beta is an important mediator of LPS plus DON-induced corticosterone and subsequent leukocyte apoptosis and, furthermore, this cytokine possibly acts through an ACTH-independent mechanism.	Corticosterone	100-114	interleukin 1 beta	Mus musculus	42-50
12966893-4	2003	In addition, cycloferon stimulated the synthesis of IL-2 and gamma INF, but decreased the concentration of IL-1b.	10-carboxymethyl-9-acridanone	13-23	interleukin 1 beta	Mus musculus	107-112
12966893-8	2003	In the course of the infectious process cycloferon suppressed the production of IL-2 and IL-1b, but did not influence the synthesis of gamma INF.	10-carboxymethyl-9-acridanone	40-50	interleukin 1 beta	Mus musculus	89-94
12787887-6	2003	Nobiletin also interfered with the lipopolysaccharide-induced production of PGE(2) and the gene expression of proinflammatory cytokines including IL-1alpha, IL-1beta, TNF-alpha and IL-6 in mouse J774A.1 macrophages.	nobiletin	0-9	interleukin 1 beta	Mus musculus	157-165
12773709-8	2003	Lastly, oral administration of PG101 highly increased serum levels of GM-CSF, IL-6, and IL-1beta.	pg101	31-36	interleukin 1 beta	Mus musculus	88-96
12786942-7	2003	Treatment of cells with either LY294002, a PI3K inhibitor, or expression of a dominant negative form of Akt drastically suppressed the IL-1beta-dependent secretion of MMP-9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	interleukin 1 beta	Mus musculus	135-143
12786942-8	2003	Pretreatment of cells with a MEK1 inhibitor, U0126, also strongly inhibited IL-1beta-dependent secretion of MMP-9.	U 0126	45-50	interleukin 1 beta	Mus musculus	76-84
12787061-5	2003	Treatment of lipopolysaccharide-primed microglia with adenosine triphosphate (ATP), an endogenous secondary stimulus, induced IL-1 beta and IL-18 release.	Adenosine Triphosphate	54-76	interleukin 1 beta	Mus musculus	126-135
12806621-1	2003	BACKGROUND &amp; AIMS: Helicobacter pylori cag(+) strains and high-expression host interleukin 1beta (IL-1beta) polymorphisms augment the risk for intestinal-type gastric adenocarcinoma, a malignancy that predominates in males.	Adenosine Monophosphate	12-15	interleukin 1 beta	Mus musculus	102-110
12759456-1	2003	In response to ATP binding, the P2X7R facilitates cation channel activation, nonspecific pore formation, rapid changes in plasma membrane morphology, and secretion of IL-1 beta from LPS-primed macrophages.	Adenosine Triphosphate	15-18	interleukin 1 beta	Mus musculus	167-176
12759456-6	2003	Blebbing was initiated at ATP concentrations &gt; or = 3 mM, but optimal IL-1 beta release occurred at 1 mM ATP.	Adenosine Triphosphate	108-111	interleukin 1 beta	Mus musculus	73-82
12759456-7	2003	P2X7R-dependent blebbing was abrogated in the presence of Rho-effector kinase inhibitors Fasudil and Y-27632, but ATP-induced IL-1 beta release was unaffected.	Adenosine Triphosphate	114-117	interleukin 1 beta	Mus musculus	126-135
12787061-5	2003	Treatment of lipopolysaccharide-primed microglia with adenosine triphosphate (ATP), an endogenous secondary stimulus, induced IL-1 beta and IL-18 release.	Adenosine Triphosphate	78-81	interleukin 1 beta	Mus musculus	126-135
12787061-7	2003	In addition, ATP induced release of mature IL-1 beta from IL-18-primed microglia.	Adenosine Triphosphate	13-16	interleukin 1 beta	Mus musculus	43-52
12606540-6	2003	We treated chondrocytes with the osteoarthritis mediator IL-1 beta, with the all-trans form of retinoic acid (ATRA), which promotes endochondral chondrocyte hypertrophy and pathologic calcification, and with C-type natriuretic peptide, an essential factor in endochondral development.	Tretinoin	95-108	interleukin 1 beta	Mus musculus	57-66
12606540-6	2003	We treated chondrocytes with the osteoarthritis mediator IL-1 beta, with the all-trans form of retinoic acid (ATRA), which promotes endochondral chondrocyte hypertrophy and pathologic calcification, and with C-type natriuretic peptide, an essential factor in endochondral development.	Tretinoin	110-114	interleukin 1 beta	Mus musculus	57-66
12609991-4	2003	Here we report that the inhibition of LTP induced by LPS and IL-1 beta was coupled with stimulation of the stress-activated protein kinase p38 in hippocampus and entorhinal cortex and that this effect was abrogated by the p38 inhibitor SB203580, while the effect of LPS was markedly attenuated in C57BL/6 IL-1RI-/- mice.	SB 203580	236-244	interleukin 1 beta	Mus musculus	61-70
12734370-5	2003	In independent experiments, ELISA analysis showed that protein levels for IL-1 beta, macrophage-inflammatory protein 2, and macrophage-inflammatory protein 1 alpha, all regulators of PMN chemotaxis, also were elevated in both groups of mice treated with clodronate-liposomes.	Clodronic Acid	254-264	interleukin 1 beta	Mus musculus	74-83
12804137-7	2003	EGTA increased BALF cell counts, neutrophils, and murine (m) macrophage inflammatory protein 2, mKC, mIL-6, and mIL-1 beta levels.	Egtazic Acid	0-4	interleukin 1 beta	Mus musculus	112-122
12616480-4	2003	The induction of IL-1beta, but not of MIP-2 or TNF-alpha, was blocked by the PI 3-kinase inhibitors LY294002 and wortmannin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	interleukin 1 beta	Mus musculus	17-25
12750010-4	2003	In contrast, LPS-induced IL-1beta or IL-10 expressions were dramatically increased by dbcAMP.	Bucladesine	86-92	interleukin 1 beta	Mus musculus	25-33
12750010-10	2003	Treatment with H89, a selective inhibitor of protein kinase A, completely reversed cAMP-induced IL-10 and IL-1beta upregulation but only partially reversed the cAMP-induced repression of TNF-alpha.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	15-18	interleukin 1 beta	Mus musculus	106-114
12750010-10	2003	Treatment with H89, a selective inhibitor of protein kinase A, completely reversed cAMP-induced IL-10 and IL-1beta upregulation but only partially reversed the cAMP-induced repression of TNF-alpha.	Cyclic AMP	83-87	interleukin 1 beta	Mus musculus	106-114
12697697-2	2003	The present study shows that inflammation induced by im injection of turpentine (TPS) in the hind limb of mice causes an increase in the plasma concentration of IL-6, but not that of IL-1 alpha or IL-1 beta, together with a prolonged (&gt;18-h) activation of the HPAA.	tissue polypeptide specific antigen	81-84	interleukin 1 beta	Mus musculus	197-206
12626429-8	2003	VIP prevents MPTP-induced activation of microglia in SNpc and striatum and the expression of the cytotoxic mediators, iNOS, interleukin 1beta, and numor necrosis factor alpha.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	13-17	interleukin 1 beta	Mus musculus	124-141
12681378-3	2003	However, tianeptine did not block apoptosis in cultured cortical neurones caused by NMDA, but reduced apoptosis when interleukin-1beta (IL-1beta) was included with NMDA.	tianeptine	9-19	interleukin 1 beta	Mus musculus	117-134
12681378-3	2003	However, tianeptine did not block apoptosis in cultured cortical neurones caused by NMDA, but reduced apoptosis when interleukin-1beta (IL-1beta) was included with NMDA.	tianeptine	9-19	interleukin 1 beta	Mus musculus	136-144
12684091-7	2003	DEP enhanced the lung expression of keratinocyte chemoattractant (KC), interleukin-1beta, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1alpha, which was inhibited by treatment with rosmarinic acid.	rosmarinic acid	208-223	interleukin 1 beta	Mus musculus	71-88
12653834-5	2003	Within 2 h after heroin administration, proliferative responses to alloantigens and the production of IL-1beta, IFN-gamma, IL-12 and NO were enhanced significantly.	Heroin	17-23	interleukin 1 beta	Mus musculus	102-110
12667655-2	2003	This study demonstrates that stimulation of synaptosomes with IL-1ra in vitro, mimicked the effects of IL-1 beta by decreasing glutamate release and increasing JNK phosphorylation.	Glutamic Acid	127-136	interleukin 1 beta	Mus musculus	103-112
12676746-9	2003	SB-208350 and PD-98059 inhibited the increase in IL-6 production induced by IL-1beta.	sb-208350	0-9	interleukin 1 beta	Mus musculus	76-84
12676746-9	2003	SB-208350 and PD-98059 inhibited the increase in IL-6 production induced by IL-1beta.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	14-22	interleukin 1 beta	Mus musculus	76-84
12716016-0	2003	Melatonin increases interleukin-1beta and decreases tumor necrosis factor alpha in the brain of mice infected with the Venezuelan equine encephalomyelitis virus.	Melatonin	0-9	interleukin 1 beta	Mus musculus	20-37
12716016-1	2003	The effect of melatonin (MLT) on the brain levels of tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in Venezuelan equine encephalomyelitis (VEE) virus infection was determined.	Melatonin	14-23	interleukin 1 beta	Mus musculus	116-124
12682268-2	2003	Injection of anti-CII Ab and LPS induces arthritis in mice in which anti-CII Ab as well as inflammatory cytokines, IL-1beta and TNF-alpha, play critical roles.	cii ab	18-24	interleukin 1 beta	Mus musculus	115-123
12531895-5	2003	Treatment of murine peritoneal macrophages with the synthetic LXR agonists GW3965 or T1317 reduces MMP-9 mRNA expression and blunts its induction by pro-inflammatory stimuli including lipopolysaccharide, interleukin-1beta, and tumor necrosis factor alpha.	GW 3965	75-81	interleukin 1 beta	Mus musculus	204-221
12644245-4	2003	Intracerebral injection of the glutamatergic analogue ibotenate to newborn mice induces cortical plate and white matter lesions mimicking the brain damage associated with cerebral palsy, and pretreatment with proinflammatory cytokines such as interleukin-1-beta or with interleukin-9 significantly exacerbates these lesions.	Ibotenic Acid	54-63	interleukin 1 beta	Mus musculus	243-261
12692403-8	2003	Thus, administration of IL-1beta to the abnormal pregnant dams increased the mortality and severity of the malformations in the embryos caused by 5ACDR, whereas PSK or OK432 decreased them.	5acdr	146-151	interleukin 1 beta	Mus musculus	24-32
12616480-4	2003	The induction of IL-1beta, but not of MIP-2 or TNF-alpha, was blocked by the PI 3-kinase inhibitors LY294002 and wortmannin.	Wortmannin	113-123	interleukin 1 beta	Mus musculus	17-25
12616480-5	2003	The nuclear factor-kappaB (NF-kappaB) inhibitor pyrrolidinedithiocarbamate (PDTC) blocked the induction of IL-1beta and TNF-alpha, but had no effect on MIP-2 expression.	pyrrolidine dithiocarbamic acid	48-74	interleukin 1 beta	Mus musculus	107-115
12616480-5	2003	The nuclear factor-kappaB (NF-kappaB) inhibitor pyrrolidinedithiocarbamate (PDTC) blocked the induction of IL-1beta and TNF-alpha, but had no effect on MIP-2 expression.	pyrrolidine dithiocarbamic acid	76-80	interleukin 1 beta	Mus musculus	107-115
12631467-6	2003	Immunostaining for IL-1beta was increased from 6 h and peaked at 24 h after tMCAO in the microglia and macrophage.	tmcao	76-81	interleukin 1 beta	Mus musculus	19-27
12584217-8	2003	In addition, the stool concentration of IL-1 beta over the four week experiment was significantly higher in mice treated with saline or Adv0 than in those treated with AdvmuIL-10 (p&lt;0.01).	Sodium Chloride	126-132	interleukin 1 beta	Mus musculus	40-49
12584217-8	2003	In addition, the stool concentration of IL-1 beta over the four week experiment was significantly higher in mice treated with saline or Adv0 than in those treated with AdvmuIL-10 (p&lt;0.01).	advmuil-10	168-178	interleukin 1 beta	Mus musculus	40-49
12703182-0	2003	[Effect of melatonin on lymphocyte proliferation and production of interleukin-2 (IL-2) and interleukin-1 beta (IL-1 beta) in mice splenocytes].	Melatonin	11-20	interleukin 1 beta	Mus musculus	92-110
12468449-6	2002	In vivo, treatment with troglitazone before ischemia prevented induction of Egr-1 and its target genes such as interleukin-1beta, monocyte chemotactic protein-1, and macrophage inflammatory protein-2.	Troglitazone	24-36	interleukin 1 beta	Mus musculus	111-128
12483539-3	2002	PP1, a specific inhibitor for the Src family protein tyrosine kinases, strongly inhibited tyrosine phosphorylation of SHPS-1 and complex formation of SHPS-1 with SHP-2 by IL-1beta.	Tyrosine	53-61	interleukin 1 beta	Mus musculus	171-179
12483539-6	2002	Moreover, IL-1beta-stimulation induced association of SHPS-1 with IL-1RAcP, a second subunit of IL-1 receptor, whereas expression of SHPS-1 mutant that lack SHP-2 binding function clearly blocked the association and tyrosine phosphorylation of endogenous SHPS-1.	Tyrosine	216-224	interleukin 1 beta	Mus musculus	10-18
12588662-0	2003	Effect of flavone derivatives on interleukin-1beta (IL-1beta) mRNA expression and IL-1beta protein synthesis in stimulated RAW 264.7 macrophages.	flavone	10-17	interleukin 1 beta	Mus musculus	33-50
12588662-0	2003	Effect of flavone derivatives on interleukin-1beta (IL-1beta) mRNA expression and IL-1beta protein synthesis in stimulated RAW 264.7 macrophages.	flavone	10-17	interleukin 1 beta	Mus musculus	52-60
12588662-3	2003	This study was designed to investigate the effect of five flavone derivatives variously substituted with hydroxyl groups (chrysin, galangin, kaempferol, quercetin and myricetin) on interleukin-1beta (IL-1beta) gene expression in stimulated RAW 264.7 macrophages.	flavone	58-65	interleukin 1 beta	Mus musculus	181-198
12588662-3	2003	This study was designed to investigate the effect of five flavone derivatives variously substituted with hydroxyl groups (chrysin, galangin, kaempferol, quercetin and myricetin) on interleukin-1beta (IL-1beta) gene expression in stimulated RAW 264.7 macrophages.	flavone	58-65	interleukin 1 beta	Mus musculus	200-208
12588662-3	2003	This study was designed to investigate the effect of five flavone derivatives variously substituted with hydroxyl groups (chrysin, galangin, kaempferol, quercetin and myricetin) on interleukin-1beta (IL-1beta) gene expression in stimulated RAW 264.7 macrophages.	kaempferol	141-151	interleukin 1 beta	Mus musculus	181-198
12588662-3	2003	This study was designed to investigate the effect of five flavone derivatives variously substituted with hydroxyl groups (chrysin, galangin, kaempferol, quercetin and myricetin) on interleukin-1beta (IL-1beta) gene expression in stimulated RAW 264.7 macrophages.	kaempferol	141-151	interleukin 1 beta	Mus musculus	200-208
12588662-3	2003	This study was designed to investigate the effect of five flavone derivatives variously substituted with hydroxyl groups (chrysin, galangin, kaempferol, quercetin and myricetin) on interleukin-1beta (IL-1beta) gene expression in stimulated RAW 264.7 macrophages.	Quercetin	153-162	interleukin 1 beta	Mus musculus	181-198
12588662-3	2003	This study was designed to investigate the effect of five flavone derivatives variously substituted with hydroxyl groups (chrysin, galangin, kaempferol, quercetin and myricetin) on interleukin-1beta (IL-1beta) gene expression in stimulated RAW 264.7 macrophages.	myricetin	167-176	interleukin 1 beta	Mus musculus	181-198
12588662-3	2003	This study was designed to investigate the effect of five flavone derivatives variously substituted with hydroxyl groups (chrysin, galangin, kaempferol, quercetin and myricetin) on interleukin-1beta (IL-1beta) gene expression in stimulated RAW 264.7 macrophages.	myricetin	167-176	interleukin 1 beta	Mus musculus	200-208
12588662-9	2003	Myricetin (hydroxyflavone with a strong antioxidant activity) significantly decreased the level of IL-1beta mRNA, but it had no effect on the IL-1beta protein synthesis.	myricetin	0-9	interleukin 1 beta	Mus musculus	99-107
12588662-9	2003	Myricetin (hydroxyflavone with a strong antioxidant activity) significantly decreased the level of IL-1beta mRNA, but it had no effect on the IL-1beta protein synthesis.	hydroxyflavone	11-25	interleukin 1 beta	Mus musculus	99-107
12588662-10	2003	The results indicated that hydroxyflavones could modulate the IL-1beta gene expression in activated RAW 264.7 macrophages via inhibiting gene transcription.	hydroxyflavones	27-42	interleukin 1 beta	Mus musculus	62-70
12513699-9	2003	In addition, we found that tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1-beta) as well as phorbol myristate acetate (PMA) also enhanced the cytotoxic effects of CEES but to a lesser extent than LPS.	2-chloroethyl ethyl sulfide	184-188	interleukin 1 beta	Mus musculus	71-89
12513699-9	2003	In addition, we found that tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1-beta) as well as phorbol myristate acetate (PMA) also enhanced the cytotoxic effects of CEES but to a lesser extent than LPS.	2-chloroethyl ethyl sulfide	184-188	interleukin 1 beta	Mus musculus	91-100
12926538-5	2003	The IL1beta mRNA expression rapidly increased and peaked at 6 h. The first increase of mRNA for TNFalpha and IFNgamma was noticed at 6-24 h and the second at the 7th day after MPTP intoxication.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	176-180	interleukin 1 beta	Mus musculus	4-11
12573707-5	2003	For the saline-treated mice: in their left cortices, interleukin-1beta levels were higher for ambidextrous mice than for right-pawed mice (P&lt;0.05); in their right cortices, interleukin-6 levels were higher for ambidextrous mice than for right-/left-pawed mice, and right-pawed mice have higher levels of interleukin-6 than left-pawed mice (P&lt;0.01).	Sodium Chloride	8-14	interleukin 1 beta	Mus musculus	53-70
12483539-2	2002	Treatment of Balb3T3 cells with IL-1beta or TNFalpha activated tyrosine phosphorylation of SHPS-1, its association with SHP-2 and the phosphorylation of Erk 1/2 and Akt.	Tyrosine	63-71	interleukin 1 beta	Mus musculus	32-40
12466233-6	2002	Co-injection of the mRNA synthesis inhibitor, actinomycin D (0.2 mg kg(-1)), with the cytokines significantly inhibited firm adhesion (49+/-13.6%) and transmigration (67.2+/-4.2%) induced by IL-1beta, but not TNFalpha.	Dactinomycin	46-59	interleukin 1 beta	Mus musculus	191-199
12466233-17	2002	The data indicate that firm adhesion and transmigration in mouse cremasteric venules stimulated by IL-1beta, but not TNFalpha, is protein synthesis dependent and mediated by endogenous generation of PAF and LTB(4).	Platelet Activating Factor	199-202	interleukin 1 beta	Mus musculus	99-107
12466233-17	2002	The data indicate that firm adhesion and transmigration in mouse cremasteric venules stimulated by IL-1beta, but not TNFalpha, is protein synthesis dependent and mediated by endogenous generation of PAF and LTB(4).	Leukotriene B4	207-210	interleukin 1 beta	Mus musculus	99-107
12457286-5	2002	In addition, AdvmuIL-10 therapy led to a significant reduction in both stool markers of inflammation (IL-1beta and TNFR-II) and acute phase response (serum amyloid protein).	advmuil-10	13-23	interleukin 1 beta	Mus musculus	102-110
12454786-11	2002	Exposure to CS caused an increase in BALF total protein, LDH, AP, and interleukin (IL)-1beta.	Cesium	12-14	interleukin 1 beta	Mus musculus	70-92
12421347-7	2002	In comparison, IL-1beta induced the release of PGE2, IL-6 and activated NF-kappaB, p38, JNK and ERK1/2 in mixed glial cultures, but failed to induce any of these responses in microglial cell cultures.	Dinoprostone	47-51	interleukin 1 beta	Mus musculus	15-23
12466348-0	2002	Interleukin-1beta induces phosphodiesterase 4B2 expression in human myometrial cells through a prostaglandin E2- and cyclic adenosine 3",5"-monophosphate-dependent pathway.	Dinoprostone	95-111	interleukin 1 beta	Mus musculus	0-17
12466348-0	2002	Interleukin-1beta induces phosphodiesterase 4B2 expression in human myometrial cells through a prostaglandin E2- and cyclic adenosine 3",5"-monophosphate-dependent pathway.	Cyclic AMP	117-153	interleukin 1 beta	Mus musculus	0-17
12384353-4	2002	In Stx-injected mice, azithromycin significantly suppressed Stx-induced TNF-alpha, IL-1beta, and IL-6 levels in serum and improved the outcome as assessed by survival rate.	Azithromycin	22-34	interleukin 1 beta	Mus musculus	83-91
12440938-0	2002	Erythropoietin and interleukin-1beta modulate nitrite production in a Swiss 3T3 cell model of rheumatoid synovial fibroblasts.	Nitrites	46-53	interleukin 1 beta	Mus musculus	19-36
12440938-4	2002	The results show that, over 3 days, both alone and in combination with the pro-inflammatory cytokine IL-1beta (10 ng/ml), rHuEPO (25 micro-units/ml) induced significant production of nitrite in cell culture supernatants.	Nitrites	183-190	interleukin 1 beta	Mus musculus	101-109
12387824-8	2002	These results suggest that IL-1beta upregulates the MMP-9 expression via production of reactive oxygen species and activation of NF-kappaB in RAW 264.7 cells.	Reactive Oxygen Species	87-110	interleukin 1 beta	Mus musculus	27-35
12453435-0	2002	The oxygen radical scavenger pyrrolidine dithiocarbamate enhances interleukin-1beta-induced cyclooxygenase-2 expression in cerebral microvascular smooth muscle cells.	Reactive Oxygen Species	4-18	interleukin 1 beta	Mus musculus	66-83
12453435-0	2002	The oxygen radical scavenger pyrrolidine dithiocarbamate enhances interleukin-1beta-induced cyclooxygenase-2 expression in cerebral microvascular smooth muscle cells.	pyrrolidine dithiocarbamic acid	29-56	interleukin 1 beta	Mus musculus	66-83
12387824-0	2002	IL-1beta induces MMP-9 via reactive oxygen species and NF-kappaB in murine macrophage RAW 264.7 cells.	Reactive Oxygen Species	27-50	interleukin 1 beta	Mus musculus	0-8
12453435-5	2002	In the presence of 100 microM PDTC, PGE(2) production induced by IL-1beta (5 ng/ml) was increased by threefold as compared with IL-1beta alone.	Prostaglandins E	36-39	interleukin 1 beta	Mus musculus	65-73
12453435-5	2002	In the presence of 100 microM PDTC, PGE(2) production induced by IL-1beta (5 ng/ml) was increased by threefold as compared with IL-1beta alone.	Prostaglandins E	36-39	interleukin 1 beta	Mus musculus	128-136
12453435-8	2002	These results suggest that endogenous oxygen radicals may blunt COX-2 induced by IL-1beta through an effect on translation.	Reactive Oxygen Species	38-53	interleukin 1 beta	Mus musculus	81-89
12370118-0	2002	Efficacy of 1400 W, a novel inhibitor of inducible nitric oxide synthase, in preventing interleukin-1beta-induced suppression of pancreatic islet function in vitro and multiple low-dose streptozotocin-induced diabetes in vivo.	N-((3-(aminomethyl)phenyl)methyl)ethanimidamide	12-18	interleukin 1 beta	Mus musculus	88-105
12138127-2	2002	Ear swelling was induced by challenge with DNFB, accompanied by infiltration of mononuclear cells, neutrophils, and eosinophils and a marked increase in mRNA levels of cytokines such as interleukin (IL)-2, interferon (IFN)-gamma, IL-4, IL-5, IL-1beta, IL-18, and tumor necrosis factor-alpha in the challenged ear skin.	Dinitrofluorobenzene	43-47	interleukin 1 beta	Mus musculus	242-250
12241641-7	2002	Furthermore, 1 mg/kg of cerivastatin significantly inhibited the expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) without lowering serum cholesterol.	cerivastatin	24-36	interleukin 1 beta	Mus musculus	123-140
12241641-7	2002	Furthermore, 1 mg/kg of cerivastatin significantly inhibited the expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) without lowering serum cholesterol.	cerivastatin	24-36	interleukin 1 beta	Mus musculus	142-150
12384241-5	2002	Treatment with IL-1beta diminished plasma growth hormone levels and increased circulating corticosterone levels irrespective of the animals stressor history.	Corticosterone	90-104	interleukin 1 beta	Mus musculus	15-23
12370118-8	2002	1400 W (50 micromol/l) fully counteracted both the suppression of glucose oxidation rate, (pro)insulin biosynthesis and nitrite accumulation caused by IL-1beta.	Nitrites	120-127	interleukin 1 beta	Mus musculus	151-159
12235261-11	2002	Likewise, significantly lower mRNA levels of Mrp2 with a corresponding decrease in cellular efflux of 5-carboxyfluorescein was seen in vitro in IL-6- and IL-1beta-treated Hepa 1-6 cells, whereas bile acids did not have significant effects.	4-carboxyfluorescein	102-122	interleukin 1 beta	Mus musculus	154-162
12235261-11	2002	Likewise, significantly lower mRNA levels of Mrp2 with a corresponding decrease in cellular efflux of 5-carboxyfluorescein was seen in vitro in IL-6- and IL-1beta-treated Hepa 1-6 cells, whereas bile acids did not have significant effects.	Bile Acids and Salts	195-205	interleukin 1 beta	Mus musculus	154-162
12500162-1	2002	OBJECTIVES: The aim of this research consisted in studying the effects of tetrapeptide Epitalon on both thymocyte proliferation and interleukin-1beta (IL-1beta) signal transduction via sphingomyelin pathway in the cerebral cortex membranes of mice exposed to stresses exerting diverse effects upon humoral immune response.	Sphingomyelins	185-198	interleukin 1 beta	Mus musculus	132-149
12500162-1	2002	OBJECTIVES: The aim of this research consisted in studying the effects of tetrapeptide Epitalon on both thymocyte proliferation and interleukin-1beta (IL-1beta) signal transduction via sphingomyelin pathway in the cerebral cortex membranes of mice exposed to stresses exerting diverse effects upon humoral immune response.	Sphingomyelins	185-198	interleukin 1 beta	Mus musculus	151-159
12500162-10	2002	CONCLUSIONS: The obtained results provided a conclusive evidence of Epitalon stress-protective effect at the level of IL-1beta signal transduction via sphingomyelin pathway in the nerve tissue, as well as at the level of target thymocyte proliferation.	Sphingomyelins	151-164	interleukin 1 beta	Mus musculus	118-126
12234923-1	2002	Macrophage activation by bacterial lipopolysaccharide (LPS) promotes the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and of secondary mediators, such as leukotrienes and prostaglandins (PGs).	Prostaglandins	265-268	interleukin 1 beta	Mus musculus	185-193
12375736-0	2002	IL-1beta regulates cellular proliferation, prostaglandin E2 synthesis, plasminogen activator activity, osteocalcin production, and bone resorptive activity of the mouse calvarial bone cells.	Dinoprostone	43-59	interleukin 1 beta	Mus musculus	0-8
12234923-1	2002	Macrophage activation by bacterial lipopolysaccharide (LPS) promotes the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and of secondary mediators, such as leukotrienes and prostaglandins (PGs).	Leukotrienes	232-244	interleukin 1 beta	Mus musculus	185-193
12234923-1	2002	Macrophage activation by bacterial lipopolysaccharide (LPS) promotes the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and of secondary mediators, such as leukotrienes and prostaglandins (PGs).	Prostaglandins	249-263	interleukin 1 beta	Mus musculus	185-193
12242464-10	2002	RESULTS: In vitro, Lisofylline preserved beta-cell insulin secretion and inhibited DNA damage of islets in the presence of IL-1 beta.	lisofylline	19-30	interleukin 1 beta	Mus musculus	123-132
12183660-10	2002	Celecoxib also attenuated the milk intake response observed 2 h after lipopolysaccharide (LPS), and the reductions of food pellet intake and body weight induced by IL-1beta and LPS in the subsequent 24 h, suggesting that the role of COX2 may be more significant biologically than that of COX1.	Celecoxib	0-9	interleukin 1 beta	Mus musculus	164-172
12198250-5	2002	In addition, IL-1beta-stimulated prostaglandin E2 production is completely inhibited by a preferential lipoxygenase inhibitor cinnaminyl-3,4-dihydroxy-alpha-cyanocinnamate.	Dinoprostone	33-49	interleukin 1 beta	Mus musculus	13-21
12198250-5	2002	In addition, IL-1beta-stimulated prostaglandin E2 production is completely inhibited by a preferential lipoxygenase inhibitor cinnaminyl-3,4-dihydroxy-alpha-cyanocinnamate.	cinnaminyl-3,4-dihydroxy-alpha-cyanocinnamate	126-171	interleukin 1 beta	Mus musculus	13-21
12198250-6	2002	We then evaluated IL-1beta-induced PGE2 production in islets purified from control C57BL/6 mice and 12-LO knockout mice lacking cytokine-inducible 12-HETE.	Dinoprostone	35-39	interleukin 1 beta	Mus musculus	18-26
12198250-7	2002	IL-1beta stimulated an 8-fold increase in PGE2 production in C57BL/6 islets but failed to stimulate PGE2 in 12-LO knockout islets.	Dinoprostone	42-46	interleukin 1 beta	Mus musculus	0-8
12096892-5	2002	With this mouse model, after infection, serum levels of interleukin (IL)-1beta and IL-6 were enhanced in Pb-exposed mice.	Lead	105-107	interleukin 1 beta	Mus musculus	56-78
12375736-4	2002	However, the induction of osteocalcin synthesis and alkaline phosphatase activity in response to vitamin D, two characteristics of the osteoblast phenotype, were significantly antagonized by IL-1beta over a similar dose range.	Vitamin D	97-106	interleukin 1 beta	Mus musculus	191-199
12235115-4	2002	We found significant upregulation of TNF-alpha, TGF-beta, RANTES, MIP-2, MCP-1, TCA3, IL-1beta, and ICAM-1 in kidneys from cisplatin-treated animals.	Cisplatin	123-132	interleukin 1 beta	Mus musculus	86-94
12235115-6	2002	Inhibitors of TNF-alpha production (GM6001, pentoxifylline) and TNF-alpha Ab"s reduced serum and kidney TNF-alpha protein levels and also blunted the cisplatin-induced increases in TNF-alpha, TGF-beta, RANTES, MIP-2, MCP-1, and IL-1beta, but not ICAM-1, mRNA.	Cisplatin	150-159	interleukin 1 beta	Mus musculus	228-236
12225870-6	2002	Moreover, NS-398 administration significantly attenuated levels of induction for the majority of inflammatory mediators examined, including TNFalpha, IL-1beta, IL-6, iNOS, ICAM-1, and MMP-9.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	10-16	interleukin 1 beta	Mus musculus	150-158
12375736-2	2002	IL-1beta stimulated cellular proliferation and the synthesis of prostaglandin E2 in the cultured cells in a dose-dependent manner.	Dinoprostone	64-80	interleukin 1 beta	Mus musculus	0-8
12138131-9	2002	TSA inhibited induction of endogenous NO production and iNOS as well as NF-kappa B element promoter activity in response to interleukin-1 beta (IL-1 beta) or lipopolysaccharide (LPS) + interferon-gamma (IFN-gamma) in both cell types without altering NF-kappa B DNA binding activity.	trichostatin A	0-3	interleukin 1 beta	Mus musculus	124-142
12138131-9	2002	TSA inhibited induction of endogenous NO production and iNOS as well as NF-kappa B element promoter activity in response to interleukin-1 beta (IL-1 beta) or lipopolysaccharide (LPS) + interferon-gamma (IFN-gamma) in both cell types without altering NF-kappa B DNA binding activity.	trichostatin A	0-3	interleukin 1 beta	Mus musculus	144-153
12133857-6	2002	Interleukin-1beta, major intrinsic protein 2, and interleukin-6 in lung homogenates after 3 days of hyperoxia were significantly higher (P &lt; 0.001) in SP-Bmon(+) mice than SP-Bmon(++) or wild-type mice.	sp-bmon	154-161	interleukin 1 beta	Mus musculus	0-17
12161415-1	2002	OBJECTIVES: The purpose of this study was to evaluate the inhibitory effect of roxithromycin on the production of interleukin (IL)-1beta, IL-6 and tumour necrosis factor-alpha (TNF-alpha) in a murine tibial osteomyelitis model using Staphylococcus aureus.	Roxithromycin	79-92	interleukin 1 beta	Mus musculus	114-136
12126975-7	2002	In addition, rhein (10, 30 microM) inhibited calcium release from mouse calvaria induced by interleukin-1 beta, prostaglandin E(2) and parathyroid hormone 1-34 human fragment.	Calcium	45-52	interleukin 1 beta	Mus musculus	92-110
12161415-6	2002	CONCLUSION: These results indicate that roxithromycin suppresses the local expression of IL-1beta and TNF-alpha, and may exhibit an anti-inflammatory effect in this osteomyelitis model.	Roxithromycin	40-53	interleukin 1 beta	Mus musculus	89-97
12166781-7	2002	Treatment with ONO-5046 and FK706 significantly reduced the ALT level as well as the serum concentrations of TNFalpha and IL-1beta.	sivelestat	15-23	interleukin 1 beta	Mus musculus	122-130
12166781-7	2002	Treatment with ONO-5046 and FK706 significantly reduced the ALT level as well as the serum concentrations of TNFalpha and IL-1beta.	FK 706	28-33	interleukin 1 beta	Mus musculus	122-130
12166781-8	2002	In addition, ONO-5046 and FK706 attenuated both hepatic microcirculatory dysfunction and liver injury mediated by TNFalpha and IL-1beta (10 microg/kg i.v.).	sivelestat	13-21	interleukin 1 beta	Mus musculus	127-135
12166781-8	2002	In addition, ONO-5046 and FK706 attenuated both hepatic microcirculatory dysfunction and liver injury mediated by TNFalpha and IL-1beta (10 microg/kg i.v.).	FK 706	26-31	interleukin 1 beta	Mus musculus	127-135
12182843-4	2002	Supernatants from cultured splenocytes and peritoneal cells taken from Linomide-treated mice contained lower levels of TNFalpha, IL-1 beta, IFN gamma and IL-12 versus higher levels of IL-4, IL-6 and IL-10 in comparison with supernatants from cultures of untreated mice.	roquinimex	71-79	interleukin 1 beta	Mus musculus	129-138
12072388-3	2002	17alpha-Ethinyl estradiol (EE) pretreatment reduced the IL-1beta induction of approximately one third of these genes.	Ethinyl Estradiol	0-25	interleukin 1 beta	Mus musculus	56-64
12043012-9	2002	On the other hand, few tartrate-resistant acid phosphatase positive cells, or IFN-g- and IL-1b-bearing cells, were seen in the PBS-injected group.	Lead	127-130	interleukin 1 beta	Mus musculus	89-94
12072388-6	2002	However, the ER agonists genistein and raloxifene both inhibited IL-1beta gene induction without stimulating the expression of prostaglandin D synthase, short heterodimer partner, or other ER-inducible genes, indicating that induction of gene expression was not required for ER inhibition of IL-1beta signaling.	Genistein	25-34	interleukin 1 beta	Mus musculus	65-73
12072388-6	2002	However, the ER agonists genistein and raloxifene both inhibited IL-1beta gene induction without stimulating the expression of prostaglandin D synthase, short heterodimer partner, or other ER-inducible genes, indicating that induction of gene expression was not required for ER inhibition of IL-1beta signaling.	Raloxifene Hydrochloride	39-49	interleukin 1 beta	Mus musculus	65-73
12098602-8	2002	In homogenized tissue, SB 207499 and AWD 12-281 inhibited significantly the secretion of interleukin 1beta induced by toluene-2,4-diisocyanate 4 and 8 h after challenge.	Toluene 2,4-Diisocyanate	118-142	interleukin 1 beta	Mus musculus	89-106
12349954-0	2002	Inhibition of TNF-alpha, IL-1beta, and IL-6 productions and NF-kappa B activation in lipopolysaccharide-activated RAW 264.7 macrophages by catalposide, an iridoid glycoside isolated from Catalpa ovata G. Don (Bignoniaceae).	catalposide	139-150	interleukin 1 beta	Mus musculus	25-33
12349954-1	2002	Catalposide, the major iridoid glycoside isolated from the stem bark of Catalpa ovata G. Don (Bignoniaceae), was found to inhibit the productions of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6), and the activation of nuclear factor kappaB (NF-kappaB) in RAW 264.7 macrophages activated with lipopolysaccharide (LPS).	catalposide	0-11	interleukin 1 beta	Mus musculus	209-217
12349954-2	2002	Catalposide also inhibited the expressions of TNF-alpha, IL-1beta, and IL-6 genes and the nuclear translocation of p65 subunit of NF-kappaB in LPS-activated RAW 264.7 cells.	catalposide	0-11	interleukin 1 beta	Mus musculus	57-65
12349954-3	2002	Flow cytometric analysis revealed that catalposide suppressed the binding of FITC-conjugated LPS to CD14 on the surface of cells, probably resulting in the inhibitory effects on TNF-alpha, IL-1beta, and IL-6 productions and NF-kappaB activation.	catalposide	39-50	interleukin 1 beta	Mus musculus	189-197
12349954-3	2002	Flow cytometric analysis revealed that catalposide suppressed the binding of FITC-conjugated LPS to CD14 on the surface of cells, probably resulting in the inhibitory effects on TNF-alpha, IL-1beta, and IL-6 productions and NF-kappaB activation.	Fluorescein-5-isothiocyanate	77-81	interleukin 1 beta	Mus musculus	189-197
12055263-5	2002	Blood stimulated with LPS or ATP individually generated minimal quantities of the leaderless polypeptide IL-1 beta, but sequential treatment of wild-type, but not P2X(7)R-deficient, blood with LPS and ATP yielded large amounts of cell-free cytokine.	Adenosine Triphosphate	29-32	interleukin 1 beta	Mus musculus	105-114
12049851-9	2002	Given at 5550 IU alpha-TA/kg, but not higher, mice elevated BAL IL-1 beta level if they were exposed to SSCS.	alpha-ta	17-25	interleukin 1 beta	Mus musculus	64-73
12044525-4	2002	RESULTS: Incubation of wild-type hepatocytes with a combination of cytokines (interleukin-1beta, tumor necrosis factor-alpha and interferon-gamma) and lipopolysaccharide (cytokines/LPS) inhibited insulin-stimulated glycogen synthesis and adenosine triphosphate (ATP) increase, and decreased the ketone body ratio (KBR) at 8-12 h, concomitant with expression of iNOS protein and NO production.	Glycogen	215-223	interleukin 1 beta	Mus musculus	78-124
12166622-2	2002	Accordingly, we have carried out a preliminary study to investigate the effects of annexin 1 in vitro on the testicular secretion of testosterone, a process inhibited by both glucocorticoids and interleukin-1beta (IL-1beta).	Testosterone	133-145	interleukin 1 beta	Mus musculus	195-212
12166622-2	2002	Accordingly, we have carried out a preliminary study to investigate the effects of annexin 1 in vitro on the testicular secretion of testosterone, a process inhibited by both glucocorticoids and interleukin-1beta (IL-1beta).	Testosterone	133-145	interleukin 1 beta	Mus musculus	214-222
12166622-7	2002	IL-1beta produced a marked decrease in the response to LH, which was blocked by indomethacin, a nonselective cyclooxygenase inhibitor and an additive effect with DEX and ANXA1(1-188).	Luteinizing Hormone	55-57	interleukin 1 beta	Mus musculus	0-8
12166622-7	2002	IL-1beta produced a marked decrease in the response to LH, which was blocked by indomethacin, a nonselective cyclooxygenase inhibitor and an additive effect with DEX and ANXA1(1-188).	Indomethacin	80-92	interleukin 1 beta	Mus musculus	0-8
12166622-7	2002	IL-1beta produced a marked decrease in the response to LH, which was blocked by indomethacin, a nonselective cyclooxygenase inhibitor and an additive effect with DEX and ANXA1(1-188).	Dexamethasone	162-165	interleukin 1 beta	Mus musculus	0-8
12166622-8	2002	These results confirm reports that glucocorticoids and IL-1beta inhibit LH-stimulated testosterone release from mouse testicular cells.	Luteinizing Hormone	72-74	interleukin 1 beta	Mus musculus	55-63
12166622-8	2002	These results confirm reports that glucocorticoids and IL-1beta inhibit LH-stimulated testosterone release from mouse testicular cells.	Testosterone	86-98	interleukin 1 beta	Mus musculus	55-63
12166622-9	2002	They also show, for the first time, that the effects of the steroids are mimicked by annexin 1 and that, in contrast to their mutually antagonistic effects in the neuroendocrine system, IL-1beta and annexin 1 exert additive actions in the testis.	Steroids	60-68	interleukin 1 beta	Mus musculus	186-194
12039996-5	2002	Treatment with 15-epi-16-(FPhO)-LXA(4)-Me was also associated with lower IL-1beta, IL-6, and GRO1 mRNA levels, whereas ICAM-1 and VCAM-1 mRNA levels were unchanged.	15-epi-16-(fpho)-lxa(4)-me	15-41	interleukin 1 beta	Mus musculus	73-81
12044525-4	2002	RESULTS: Incubation of wild-type hepatocytes with a combination of cytokines (interleukin-1beta, tumor necrosis factor-alpha and interferon-gamma) and lipopolysaccharide (cytokines/LPS) inhibited insulin-stimulated glycogen synthesis and adenosine triphosphate (ATP) increase, and decreased the ketone body ratio (KBR) at 8-12 h, concomitant with expression of iNOS protein and NO production.	Adenosine Triphosphate	238-260	interleukin 1 beta	Mus musculus	78-124
12044525-4	2002	RESULTS: Incubation of wild-type hepatocytes with a combination of cytokines (interleukin-1beta, tumor necrosis factor-alpha and interferon-gamma) and lipopolysaccharide (cytokines/LPS) inhibited insulin-stimulated glycogen synthesis and adenosine triphosphate (ATP) increase, and decreased the ketone body ratio (KBR) at 8-12 h, concomitant with expression of iNOS protein and NO production.	Adenosine Triphosphate	262-265	interleukin 1 beta	Mus musculus	78-124
12044525-4	2002	RESULTS: Incubation of wild-type hepatocytes with a combination of cytokines (interleukin-1beta, tumor necrosis factor-alpha and interferon-gamma) and lipopolysaccharide (cytokines/LPS) inhibited insulin-stimulated glycogen synthesis and adenosine triphosphate (ATP) increase, and decreased the ketone body ratio (KBR) at 8-12 h, concomitant with expression of iNOS protein and NO production.	Ketones	295-301	interleukin 1 beta	Mus musculus	78-124
12010781-8	2002	IL-1beta induced marked release of IL-6 and prostaglandin-E(2) (PGE(2)) in the culture medium, and activated nuclear factor-kappa B (NFkappaB) and the mitogen-activated protein kinases (MAPK) p38, c-Jun N-terminal kinase (JNK) and the extracellular signal-regulated protein kinase (ERK1/2) in cells from wildtype mice.	Prostaglandins E	44-59	interleukin 1 beta	Mus musculus	0-8
12010781-8	2002	IL-1beta induced marked release of IL-6 and prostaglandin-E(2) (PGE(2)) in the culture medium, and activated nuclear factor-kappa B (NFkappaB) and the mitogen-activated protein kinases (MAPK) p38, c-Jun N-terminal kinase (JNK) and the extracellular signal-regulated protein kinase (ERK1/2) in cells from wildtype mice.	Prostaglandins E	64-67	interleukin 1 beta	Mus musculus	0-8
11943809-0	2002	ADP and AMP induce interleukin-1beta release from microglial cells through activation of ATP-primed P2X7 receptor channels.	Adenosine Diphosphate	0-3	interleukin 1 beta	Mus musculus	19-36
12022763-0	2002	Effect of FR167653, a novel inhibitor of tumor necrosis factor-alpha and interleukin-1beta synthesis on lipopolysaccharide-induced hepatic microvascular dysfunction in mice.	FR 167653	10-18	interleukin 1 beta	Mus musculus	73-90
11994502-3	2002	In addition, results show that the inhibition of IFN-gamma synthesis and splenic- and lymph node-lymphocyte proliferation and activation of macrophage TNF-alpha and IL-1beta synthesis occurred only with chronic morphine treatment but not with CORT infusion.	Morphine	211-219	interleukin 1 beta	Mus musculus	165-173
11956484-0	2002	Tumor necrosis factor-alpha and interleukin-1beta mediate the production of nitric oxide involved in the pathogenesis of ifosfamide induced hemorrhagic cystitis in mice.	Nitric Oxide	76-88	interleukin 1 beta	Mus musculus	32-49
11956484-0	2002	Tumor necrosis factor-alpha and interleukin-1beta mediate the production of nitric oxide involved in the pathogenesis of ifosfamide induced hemorrhagic cystitis in mice.	Ifosfamide	121-131	interleukin 1 beta	Mus musculus	32-49
11956484-1	2002	PURPOSE: We investigated the participation of nitric oxide in ifosfamide induced hemorrhagic cystitis in mice, and the involvement of tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta in the induction of nitric oxide production in this model.	Nitric Oxide	215-227	interleukin 1 beta	Mus musculus	172-194
11956484-9	2002	of the TNF-alpha and IL-1beta synthesis inhibitor pentoxifylline.	Pentoxifylline	50-64	interleukin 1 beta	Mus musculus	21-29
11956484-16	2002	The induction of inducible nitric oxide synthase in the urothelium appears to depend on the synergistic effect of IL-1beta and TNF-alpha.	nitric	27-33	interleukin 1 beta	Mus musculus	114-122
11943809-2	2002	Activation of P2X(7) purinoceptors by ATP or 3"-O-(4-benzoyl)-benzoyl ATP (BzATP) induces the formation of cytolytic pores and provokes release of interleukin-1beta from immune cells.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	45-73	interleukin 1 beta	Mus musculus	147-164
11943809-2	2002	Activation of P2X(7) purinoceptors by ATP or 3"-O-(4-benzoyl)-benzoyl ATP (BzATP) induces the formation of cytolytic pores and provokes release of interleukin-1beta from immune cells.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	75-80	interleukin 1 beta	Mus musculus	147-164
11943809-9	2002	Finally, ADP and AMP stimulated the release of interleukin-1beta from ATP-primed mouse and human microglial cells.	Adenosine Diphosphate	9-12	interleukin 1 beta	Mus musculus	47-64
11943809-0	2002	ADP and AMP induce interleukin-1beta release from microglial cells through activation of ATP-primed P2X7 receptor channels.	Adenosine Monophosphate	8-11	interleukin 1 beta	Mus musculus	19-36
11943809-9	2002	Finally, ADP and AMP stimulated the release of interleukin-1beta from ATP-primed mouse and human microglial cells.	Adenosine Monophosphate	17-20	interleukin 1 beta	Mus musculus	47-64
11943809-2	2002	Activation of P2X(7) purinoceptors by ATP or 3"-O-(4-benzoyl)-benzoyl ATP (BzATP) induces the formation of cytolytic pores and provokes release of interleukin-1beta from immune cells.	Adenosine Triphosphate	38-41	interleukin 1 beta	Mus musculus	147-164
11943809-9	2002	Finally, ADP and AMP stimulated the release of interleukin-1beta from ATP-primed mouse and human microglial cells.	Adenosine Triphosphate	70-73	interleukin 1 beta	Mus musculus	47-64
11923614-7	2002	RESULTS: Inosine downregulated the LPS-induced expression of TNF-alpha, IL-1beta, IL-6 and MIP-2 and tended to reduce MIP-1alpha, whereas it enhanced the production of IL-4.	Inosine	9-16	interleukin 1 beta	Mus musculus	72-80
11908924-8	2002	Treatment of RST mice with the glucocorticoid receptor antagonist RU486 restored IL-1 beta mRNA expression at day 1.	Mifepristone	66-71	interleukin 1 beta	Mus musculus	81-90
12021104-1	2002	The expression of IL-1beta in the NOD mouse pancreas was examined following disease acceleration with cyclophosphamide (Cy).	Cyclophosphamide	102-118	interleukin 1 beta	Mus musculus	18-26
12021104-1	2002	The expression of IL-1beta in the NOD mouse pancreas was examined following disease acceleration with cyclophosphamide (Cy).	Cyclophosphamide	120-122	interleukin 1 beta	Mus musculus	18-26
12021104-4	2002	At day 0 (Cy group), IL-1beta was expressed in selective intraislet macrophages but showed an increase from day 7 onwards in macrophages, a few beta cells, and somatostatin cells.	Cyclophosphamide	10-12	interleukin 1 beta	Mus musculus	21-29
12021104-6	2002	In the Cy group a proportion of macrophages coexpressed IL-1beta and inducible nitric oxide synthase (iNOS).	Cyclophosphamide	7-9	interleukin 1 beta	Mus musculus	56-64
12197773-11	2002	Cytokines IL-1beta, IL-2, and IFN-gamma in the BIO supernatants of cells cultured in the presence of NS + NT had a significantly higher response than the control vessel.	ns + nt	101-108	interleukin 1 beta	Mus musculus	10-18
11880505-3	2002	In addition, we show that minocycline not only prevents MPTP-induced activation of microglia but also the formation of mature interleukin-1beta and the activation of NADPH-oxidase and inducible nitric oxide synthase (iNOS), three key microglial-derived cytotoxic mediators.	Minocycline	26-37	interleukin 1 beta	Mus musculus	126-143
11857482-0	2002	Modulation of goldfish testicular testosterone production in vitro by tumor necrosis factor alpha, interleukin-1beta, and macrophage conditioned media.	Testosterone	34-46	interleukin 1 beta	Mus musculus	99-116
11867742-3	2002	A single oral administration of SAHA to mice dose-dependently reduced circulating TNF-alpha, IL-1-beta, IL-6, and IFN-gamma induced by lipopolysaccharide (LPS).	Vorinostat	32-36	interleukin 1 beta	Mus musculus	93-102
11751881-1	2002	Formation of these oxidized phospholipids in response to interleukin-1beta.	Phospholipids	28-41	interleukin 1 beta	Mus musculus	57-74
11891437-7	2002	This is surprising because NMDA leads to an increase in endogenous IL-1beta synthesis.	N-Methylaspartate	27-31	interleukin 1 beta	Mus musculus	67-75
11748220-6	2002	Antisense oligonucleotide suppression of zfm1 protein synthesis mimicked the stimulatory effects of IL-1 beta and TNF alpha on SMC proliferation and expression of the chemokine MCP-1 and the vascular cell adhesion molecule-1.	Oligonucleotides	10-25	interleukin 1 beta	Mus musculus	100-109
11850347-0	2002	Crucial role of interleukin-1beta and nitric oxide synthase in silica-induced inflammation and apoptosis in mice.	Silicon Dioxide	63-69	interleukin 1 beta	Mus musculus	16-33
11850347-1	2002	Crystalline silica stimulates macrophages in vitro to release interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and nitric oxide (NO) and induces apoptosis of macrophages.	Silicon Dioxide	12-18	interleukin 1 beta	Mus musculus	62-79
11850347-1	2002	Crystalline silica stimulates macrophages in vitro to release interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and nitric oxide (NO) and induces apoptosis of macrophages.	Silicon Dioxide	12-18	interleukin 1 beta	Mus musculus	81-89
11850347-4	2002	Both NO release and apoptosis could be inhibited by neutralizing anti-IL-1beta antibody or the NO synthase (NOS) inhibitor N(G)-nitro-L-arginine-methyl ester (L-NAME), demonstrating the requirement for IL-1beta-mediated NO release in silica-induced apoptosis.	NG-Nitroarginine Methyl Ester	123-157	interleukin 1 beta	Mus musculus	202-210
11850347-4	2002	Both NO release and apoptosis could be inhibited by neutralizing anti-IL-1beta antibody or the NO synthase (NOS) inhibitor N(G)-nitro-L-arginine-methyl ester (L-NAME), demonstrating the requirement for IL-1beta-mediated NO release in silica-induced apoptosis.	NG-Nitroarginine Methyl Ester	159-165	interleukin 1 beta	Mus musculus	202-210
11706016-4	2002	The objective of the present study was to test the hypothesis that IL-1beta, IL-18, and/or caspase-1 activation contribute directly to macrophage cell death induced by LPS and ATP.	Adenosine Triphosphate	176-179	interleukin 1 beta	Mus musculus	67-75
11840449-12	2002	IFNgamma production by T cell clones was highly sensitive to ASA-mediated suppression, whereas IL-1beta production by lipopolysaccharide-stimulated monocytes responded primarily to dexamethasone.	Dexamethasone	181-194	interleukin 1 beta	Mus musculus	95-103
11840456-9	2002	Vitamin E treatment of the transgenic animals led to a significant decrease in the levels of interleukin-(IL-1beta) but not tumor necrosis factor alpha.	Vitamin E	0-9	interleukin 1 beta	Mus musculus	106-114
11853703-1	2002	The effects of an important new anti-inflammatory agent, the selective cyclooxygenase-2 inhibitor celecoxib, on bone resorption and osteoclastogenesis elicited by the inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), the endotoxin lipopolysaccharide (LPS), and the systemic hormones 1alpha,25-dihydroxyvitamin D(3) and parathyroid hormone were examined in vitro.	Celecoxib	98-107	interleukin 1 beta	Mus musculus	190-207
11853703-1	2002	The effects of an important new anti-inflammatory agent, the selective cyclooxygenase-2 inhibitor celecoxib, on bone resorption and osteoclastogenesis elicited by the inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), the endotoxin lipopolysaccharide (LPS), and the systemic hormones 1alpha,25-dihydroxyvitamin D(3) and parathyroid hormone were examined in vitro.	Celecoxib	98-107	interleukin 1 beta	Mus musculus	209-217
11853703-4	2002	Celecoxib (0.1 microM) completely inhibited the calcium release induced by IL-1beta, TNF-alpha, and LPS.	Celecoxib	0-9	interleukin 1 beta	Mus musculus	75-83
11853703-4	2002	Celecoxib (0.1 microM) completely inhibited the calcium release induced by IL-1beta, TNF-alpha, and LPS.	Calcium	48-55	interleukin 1 beta	Mus musculus	75-83
11853703-8	2002	These results indicate that, under certain conditions, cyclooxygenase-2-dependent prostaglandin synthesis is critical for the bone resorption induced by IL-1beta, TNF-alpha, and LPS, and for the osteoclastogenesis induced by these pro-inflammatory molecules and calciotropic hormones.	Prostaglandins	82-95	interleukin 1 beta	Mus musculus	153-161
11856644-12	2002	Consistent with decreased osteoclastogenesis, raloxifene inhibited the mRNA expression of interleukin (IL)-1beta and IL-6 at a low concentration, but not at a high concentration, whereas 17beta-estradiol had similar effects on IL-6 and inhibited IL-1beta at both concentrations.	Raloxifene Hydrochloride	46-56	interleukin 1 beta	Mus musculus	90-112
11856644-12	2002	Consistent with decreased osteoclastogenesis, raloxifene inhibited the mRNA expression of interleukin (IL)-1beta and IL-6 at a low concentration, but not at a high concentration, whereas 17beta-estradiol had similar effects on IL-6 and inhibited IL-1beta at both concentrations.	Raloxifene Hydrochloride	46-56	interleukin 1 beta	Mus musculus	246-254
11860279-1	2002	Activation of purinergic P2X7 receptors, principally by extracellular ATP, promotes the processing and release of the cytokine interleukin-1beta (IL-1beta) and induces cell death in activated microglia and macrophages.	Adenosine Triphosphate	70-73	interleukin 1 beta	Mus musculus	127-144
11828002-10	2002	Finally, reconstitution of full-length FADD in the FADD(-/-) MEFs completely reversed the enhanced activation of NF-kappa B elicited by either LPS or IL-1 beta.	fadd	39-43	interleukin 1 beta	Mus musculus	150-159
11828002-10	2002	Finally, reconstitution of full-length FADD in the FADD(-/-) MEFs completely reversed the enhanced activation of NF-kappa B elicited by either LPS or IL-1 beta.	fadd(-/-) mefs	51-65	interleukin 1 beta	Mus musculus	150-159
12067102-2	2002	On processing bone metabolism, PGE2 accelerated production of IL-1beta in fetal mouse osteoblast and stimulated physiological activation substance, IL-1beta.	Dinoprostone	31-35	interleukin 1 beta	Mus musculus	62-70
11860156-8	2002	The present work investigated the possibility that the action of IL1beta in the Dyn system might release prostaglandins so that the Dyn and nociceptin antianalgesic systems would overlap at these points.	Prostaglandins	105-119	interleukin 1 beta	Mus musculus	65-72
12067102-2	2002	On processing bone metabolism, PGE2 accelerated production of IL-1beta in fetal mouse osteoblast and stimulated physiological activation substance, IL-1beta.	Dinoprostone	31-35	interleukin 1 beta	Mus musculus	148-156
12067102-3	2002	The novel class of Src tyrosine kinase inhibitors, Herbimycin A (HERB) and HHI reduced COX-2 mRNA levels as well as PGE2 production induced by IL-1beta, TNF-alpha and IL-6.	herbimycin	51-63	interleukin 1 beta	Mus musculus	143-151
12067102-3	2002	The novel class of Src tyrosine kinase inhibitors, Herbimycin A (HERB) and HHI reduced COX-2 mRNA levels as well as PGE2 production induced by IL-1beta, TNF-alpha and IL-6.	Dinoprostone	116-120	interleukin 1 beta	Mus musculus	143-151
12365794-12	2002	At days 11 and 14, a proportion of Fas-positive intra-islet macrophages co-expressed interleukin-1beta and inducible nitric oxide synthase.	ammonium ferrous sulfate	35-38	interleukin 1 beta	Mus musculus	85-102
11989721-3	2002	NTL was able to induce the expression of IL-1beta, TNF-alpha, and immunoreactive nitric oxide synthase (NOS) in both splenocytes and macrophages in vivo after 10-day consecutive peritoneal injections of 5 mg NTL x kg(-1) x day(-1) in the mouse.	Netilmicin	0-3	interleukin 1 beta	Mus musculus	41-49
12365794-15	2002	Interleukin-1beta in intra-islet macrophages may induce Fas and inducible nitric oxide synthase expression in an autocrine and paracrine manner and mediate beta cell destruction or even death of some macrophages and T cells.	ammonium ferrous sulfate	56-59	interleukin 1 beta	Mus musculus	0-17
12210732-7	2002	On the other hand, IL-1beta, a Th1 proinflammatory cytokine, dramatically increases nitrite and nitrate levels, as well as inducible nitric oxide synthase (iNOS) transcripts and also upregulates islet ICAM-1 expression as well as circulating ICAM-1 levels.	Nitrites	84-91	interleukin 1 beta	Mus musculus	19-27
11743653-3	2002	Judging from the expression of various inflammatory cytokine genes in TNF+/+ and TNF-/- mice, the residual tumor promoting activity of TPA in TNF-/- mice may be dependent on expression of IL-1alpha and IL-1beta genes.	Tetradecanoylphorbol Acetate	135-138	interleukin 1 beta	Mus musculus	202-210
12210732-7	2002	On the other hand, IL-1beta, a Th1 proinflammatory cytokine, dramatically increases nitrite and nitrate levels, as well as inducible nitric oxide synthase (iNOS) transcripts and also upregulates islet ICAM-1 expression as well as circulating ICAM-1 levels.	Nitrates	96-103	interleukin 1 beta	Mus musculus	19-27
11709312-0	2001	Activation by 9-(R)-[2-(phosphonomethoxy)propyl]adenine of chemokine (RANTES, macrophage inflammatory protein 1alpha) and cytokine (tumor necrosis factor alpha, interleukin-10 [IL-10], IL-1beta) production.	9-(r)-[2-(phosphonomethoxy)propyl]adenine	14-55	interleukin 1 beta	Mus musculus	185-193
12437026-4	2002	IL-1beta production in response to other microbial stimulators, such as Pansorbin, Sansorbin, insoluble peptidoglycan, and Taxol, was also potentiated by rCTB.	pansorbin	72-81	interleukin 1 beta	Mus musculus	0-8
12437026-4	2002	IL-1beta production in response to other microbial stimulators, such as Pansorbin, Sansorbin, insoluble peptidoglycan, and Taxol, was also potentiated by rCTB.	sansorbin	83-92	interleukin 1 beta	Mus musculus	0-8
12437026-4	2002	IL-1beta production in response to other microbial stimulators, such as Pansorbin, Sansorbin, insoluble peptidoglycan, and Taxol, was also potentiated by rCTB.	Paclitaxel	123-128	interleukin 1 beta	Mus musculus	0-8
12481156-3	2002	METHODS: The effects of prazosin, an alpha1/alpha2-adrenergic receptor antagonist, on the production of interleukin (IL)-1beta and IL-10 induced by LPS was studied in mice selected for their paw preference.	Prazosin	24-32	interleukin 1 beta	Mus musculus	104-126
12481156-6	2002	Prazosin, 10 mg/kg, injected intraperitoneally half an hour before LPS, reduced plasma levels of IL-1beta and abolished the effect of lateralization.	Prazosin	0-8	interleukin 1 beta	Mus musculus	97-105
12907841-6	2002	Plasma corticosterone (CORT) rose from basal levels of 99 to 831 nmol/l in knockout mice upon IL-1beta stimulation, whereas in wild-type mice CORT levels rose from 112 to 841 nmol/l.	Corticosterone	7-21	interleukin 1 beta	Mus musculus	94-102
12907841-6	2002	Plasma corticosterone (CORT) rose from basal levels of 99 to 831 nmol/l in knockout mice upon IL-1beta stimulation, whereas in wild-type mice CORT levels rose from 112 to 841 nmol/l.	Corticosterone	23-27	interleukin 1 beta	Mus musculus	94-102
11709312-5	2001	Using the in vitro test system of mouse macrophages and lymphocytes, it has been found that PMPA stimulates macrophage secretion of interleukin-1beta (IL-1beta), IL-10, and tumor necrosis factor alpha.	Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination	92-96	interleukin 1 beta	Mus musculus	132-149
11709312-5	2001	Using the in vitro test system of mouse macrophages and lymphocytes, it has been found that PMPA stimulates macrophage secretion of interleukin-1beta (IL-1beta), IL-10, and tumor necrosis factor alpha.	Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination	92-96	interleukin 1 beta	Mus musculus	151-159
11502543-4	2001	Pretreatment with CLI significantly improved survival in a dose-dependent manner (CLI, at 160, 300, and 440 mg/kg) and significantly lowered the peak concentrations of tumor necrosis factor alpha and interleukin-1beta (IL-1beta) in serum.	Clindamycin	18-21	interleukin 1 beta	Mus musculus	200-217
11723025-6	2001	Valsartan attenuated the expression of MCP-1, TNF-alpha, IL-6, IL-1beta, and infiltration of leukocytes and macrophages in the injured arteries; however, these effects of valsartan were less prominent in Agtr2- mice.	Valsartan	0-9	interleukin 1 beta	Mus musculus	63-71
11699591-4	2001	Furthermore, a reverse transcription-PCR assay revealed that SAA 10 microg/ml could induce mRNA accumulation of tumour necrosis factor-alpha, interleukin (IL)-1beta and IL-6 as well as iNOS.	saa	61-64	interleukin 1 beta	Mus musculus	142-164
11729116-8	2001	Analysis of cytokine levels in colon homogenates showed a significant decrease in TNF-alpha, IL-6, and IL-1beta after rhIL-18BPa treatment but no effect on interferon gamma.	18bpa	123-128	interleukin 1 beta	Mus musculus	103-111
11606625-7	2001	Low and high doses of curcumin significantly lowered oxidized proteins and interleukin-1beta, a proinflammatory cytokine elevated in the brains of these mice.	Curcumin	22-30	interleukin 1 beta	Mus musculus	75-92
11602679-7	2001	Activation of central benzodiazepine receptors preceded the IL1beta step because flumazenil inhibited Dyn but not IL1beta antianalgesia.	Flumazenil	81-91	interleukin 1 beta	Mus musculus	60-67
11602679-8	2001	On the other hand, [1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide], an antagonist for peripheral benzodiazepine receptors that have also recently been detected in brain tissue, inhibited IL1beta antianalgesia; these latter benzodiazepine receptors formed a separate step after the flumazenil-sensitive benzodiazepine receptor step.	1-(2-chlorophenyl)-n-methyl	20-47	interleukin 1 beta	Mus musculus	214-221
11602679-8	2001	On the other hand, [1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide], an antagonist for peripheral benzodiazepine receptors that have also recently been detected in brain tissue, inhibited IL1beta antianalgesia; these latter benzodiazepine receptors formed a separate step after the flumazenil-sensitive benzodiazepine receptor step.	methylpropyl)-3-isoquinolinecarboxamide	53-92	interleukin 1 beta	Mus musculus	214-221
11578781-4	2001	Knowledge of cellular mechanisms and high throughput screens of a pharmacologically focused chemical library allowed the discovery of novel pyridazine-based compounds that are cell permeable ligand modulators of gene regulating protein kinases involved in the induction of iNOS and IL-1 beta in activated glia.	pyridazine	140-150	interleukin 1 beta	Mus musculus	282-291
11582579-7	2001	The protein kinase C (PKC) inhibitor H7 and the phosphatidylinositol 3-kinase (PI3-kinase) inhibitor wortmannin inhibited induction of IL-1beta and IL-6 expression, which suggests that radiation-induced IL-1beta and IL-6 expression is achieved by PKC- and PI3-kinase-mediated signaling.	Wortmannin	101-111	interleukin 1 beta	Mus musculus	135-143
11582579-7	2001	The protein kinase C (PKC) inhibitor H7 and the phosphatidylinositol 3-kinase (PI3-kinase) inhibitor wortmannin inhibited induction of IL-1beta and IL-6 expression, which suggests that radiation-induced IL-1beta and IL-6 expression is achieved by PKC- and PI3-kinase-mediated signaling.	Wortmannin	101-111	interleukin 1 beta	Mus musculus	203-211
11683585-3	2001	In this regard, we found that the characteristic decrease in IL-1beta production after LPS stimulation could be abrogated by treatment of macrophages with the protein kinase inhibitor staurosporine.	Staurosporine	184-197	interleukin 1 beta	Mus musculus	61-69
11683585-6	2001	Staurosporine also mediated an enhancement of LPS-induced IL-1beta promoter activity measured in RAW 264.7 cells transiently transfected with an IL-1beta reporter plasmid.	Staurosporine	0-13	interleukin 1 beta	Mus musculus	58-66
11683585-6	2001	Staurosporine also mediated an enhancement of LPS-induced IL-1beta promoter activity measured in RAW 264.7 cells transiently transfected with an IL-1beta reporter plasmid.	Staurosporine	0-13	interleukin 1 beta	Mus musculus	145-153
11683585-7	2001	This increase paralleled the enhancement of IL-1beta mRNA by staurosporine both in intensity and time after LPS stimulation, suggesting that the negative regulation of IL-1beta is exerted primarily at the level of transcription.	Staurosporine	61-74	interleukin 1 beta	Mus musculus	44-52
11683585-7	2001	This increase paralleled the enhancement of IL-1beta mRNA by staurosporine both in intensity and time after LPS stimulation, suggesting that the negative regulation of IL-1beta is exerted primarily at the level of transcription.	Staurosporine	61-74	interleukin 1 beta	Mus musculus	168-176
11683585-8	2001	This regulation may be at least partially due to an observed inhibition of nitric oxide production by staurosporine in LPS-activated macrophages, which was correlated with enhanced IL-1beta production.	Staurosporine	102-115	interleukin 1 beta	Mus musculus	181-189
11478964-5	2001	When MPACs were exposed to Jararhagin treated with EDTA, TNF-alpha and IL-1beta production was sustained throughout the culture period and IL-6 production was observed.	mpacs	5-10	interleukin 1 beta	Mus musculus	71-79
11478964-6	2001	TNF-alpha, IL-6 and IL-1beta mRNA were detected 4h after stimulation with either native or EDTA-treated jararhagin.	Edetic Acid	91-95	interleukin 1 beta	Mus musculus	20-28
11502543-4	2001	Pretreatment with CLI significantly improved survival in a dose-dependent manner (CLI, at 160, 300, and 440 mg/kg) and significantly lowered the peak concentrations of tumor necrosis factor alpha and interleukin-1beta (IL-1beta) in serum.	Clindamycin	18-21	interleukin 1 beta	Mus musculus	219-227
11683374-10	2001	In vitro inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPPIX) in RAW 264.7 macrophages markedly attenuated tumor necrosis factor-alpha (TNF-alpha), but strongly increased interleukin-1beta (IL-1beta) release in RAW 264.7 macrophages in vitro.	tin protoporphyrin IX	73-79	interleukin 1 beta	Mus musculus	190-207
11592385-12	2001	Furthermore, the gene expression of IL-1alpha, IL-1beta, TNFalpha, and IL-6, as well as the production of IL-1beta and IL-6, were inhibited by triptolide in the LPS-treated mouse macrophages.	triptolide	143-153	interleukin 1 beta	Mus musculus	47-55
11592385-12	2001	Furthermore, the gene expression of IL-1alpha, IL-1beta, TNFalpha, and IL-6, as well as the production of IL-1beta and IL-6, were inhibited by triptolide in the LPS-treated mouse macrophages.	triptolide	143-153	interleukin 1 beta	Mus musculus	106-114
11554785-3	2001	A subset of the genes examined (e.g., G-CSF, MIP-2, iNOS, and IL-1 beta, and GM-CSF) was upregulated &gt;3-20-fold by both LPS and paclitaxel in the DA-3 cell line, while IP-10 mRNA was induced by paclitaxel, but not by LPS.	Paclitaxel	131-141	interleukin 1 beta	Mus musculus	62-71
11554785-3	2001	A subset of the genes examined (e.g., G-CSF, MIP-2, iNOS, and IL-1 beta, and GM-CSF) was upregulated &gt;3-20-fold by both LPS and paclitaxel in the DA-3 cell line, while IP-10 mRNA was induced by paclitaxel, but not by LPS.	Paclitaxel	197-207	interleukin 1 beta	Mus musculus	62-71
11591114-1	2001	IL-1beta(-/-) mice manifest an impaired contact hypersensitivity response to the hapten trinitrochlorobenzene, with the principle defect expressed during the sensitization phase of this response.	Picryl Chloride	88-109	interleukin 1 beta	Mus musculus	0-8
11591114-3	2001	In addition, the delivery of epicutaneously applied fluorescein isothiocyanate to draining lymph nodes was decreased in IL-1beta(-/-) mice.	Fluorescein-5-isothiocyanate	52-78	interleukin 1 beta	Mus musculus	120-128
11342558-11	2001	Furthermore, SOCS-1 also suppressed the cellular effects that require the combined presence of IL-1 beta and IFN-gamma: induction of nitric oxide production and apoptosis.	Nitric Oxide	133-145	interleukin 1 beta	Mus musculus	95-104
11520053-2	2001	Oral administration of LL-Z1271alpha to LPS-challenged mice caused significant lowering in the IL-1beta levels in peritoneal cavity.	LL-Z 1271alpha	23-36	interleukin 1 beta	Mus musculus	95-103
11342558-4	2001	As described previously IFN-gamma, in combination with IL-1 beta, also induces inducible NO synthase expression and apoptosis (Dupraz, P., Cottet, S., Hamburger, F., Dolci, W., Felley-Bosco, E., and Thorens, B.	dupraz	127-133	interleukin 1 beta	Mus musculus	55-64
11401957-9	2001	Significantly, Pa neither increased IL-1beta nor induced behavioral changes in mice, but did induce the anti-inflammatory cytokine IL-10.	Protactinium	15-17	interleukin 1 beta	Mus musculus	36-44
11683374-10	2001	In vitro inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPPIX) in RAW 264.7 macrophages markedly attenuated tumor necrosis factor-alpha (TNF-alpha), but strongly increased interleukin-1beta (IL-1beta) release in RAW 264.7 macrophages in vitro.	tin protoporphyrin IX	73-79	interleukin 1 beta	Mus musculus	209-217
11758808-0	2001	Immunoexpression of interleukin-1beta in pancreatic islets of NOD mice during cyclophosphamide-accelerated diabetes: co-localization in macrophages and endocrine cells and its attenuation with oral nicotinamide.	Cyclophosphamide	78-94	interleukin 1 beta	Mus musculus	20-37
11683374-10	2001	In vitro inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPPIX) in RAW 264.7 macrophages markedly attenuated tumor necrosis factor-alpha (TNF-alpha), but strongly increased interleukin-1beta (IL-1beta) release in RAW 264.7 macrophages in vitro.	tin protoporphyrin IX	50-71	interleukin 1 beta	Mus musculus	190-207
11683374-10	2001	In vitro inhibition of HO-1 enzymatic activity by tin protoporphyrin IX (SnPPIX) in RAW 264.7 macrophages markedly attenuated tumor necrosis factor-alpha (TNF-alpha), but strongly increased interleukin-1beta (IL-1beta) release in RAW 264.7 macrophages in vitro.	tin protoporphyrin IX	50-71	interleukin 1 beta	Mus musculus	209-217
11426330-3	2001	Intravenous inoculation of M5076 into mice caused a marked increase in gene expression of interleukin-1beta, tumor necrosis factor-alpha and intercellular adhesion molecule-1 in the liver, whereas intravenous treatment with NF-kappaB decoy ODN reduced M5076-induced transactivation of these genes.	m5076	27-32	interleukin 1 beta	Mus musculus	90-136
11349028-5	2001	Both accumulation of pro-IL-1beta protein and expression of IL-1beta mRNA in macrophages by stimulation with BcLPS-3 were much weaker than by stimulation with SaeLPS.	saelps	159-165	interleukin 1 beta	Mus musculus	25-33
11508496-2	2001	This study demonstrates the involvement of the sphingomyelin cascade in IL-1beta signal transduction in the P2 membrane fraction of the mouse cerebral cortex.	Sphingomyelins	47-60	interleukin 1 beta	Mus musculus	72-80
11508496-7	2001	The results obtained here lead to the conclusion that the action of IL-1beta in the CNS is mediated by the IL-1 type I receptor and activation of neutral sphingomyelinase as the initiating enzyme of the sphingomyelin cascade.	Sphingomyelins	154-167	interleukin 1 beta	Mus musculus	68-76
11758808-0	2001	Immunoexpression of interleukin-1beta in pancreatic islets of NOD mice during cyclophosphamide-accelerated diabetes: co-localization in macrophages and endocrine cells and its attenuation with oral nicotinamide.	Niacinamide	198-210	interleukin 1 beta	Mus musculus	20-37
11758808-15	2001	Exposure of NOD mice to oral nicotinamide was associated with a considerably reduced expression of interleukin-1beta cells within the islet at day 11 (p = 0.002).	Niacinamide	29-41	interleukin 1 beta	Mus musculus	99-116
11758808-16	2001	We conclude that cylophosphamide treatment enhances the expression of interleukin-1beta in selective macrophages, somatostatin and beta cells during the course of the disease.	cylophosphamide	17-32	interleukin 1 beta	Mus musculus	70-87
11758808-21	2001	Oral nicotinamide may attenuate intra-islet expression of interleukin-1beta and thus inducible nitric oxide synthase during prevention of Type 1 diabetes in this animal model.	Niacinamide	5-17	interleukin 1 beta	Mus musculus	58-75
11285013-1	2001	Low doses of lipopolysaccharide, tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), or exposure to a stressor (restraint) increased plasma corticosterone levels.	Corticosterone	162-176	interleukin 1 beta	Mus musculus	75-93
11345969-3	2001	Neurogenic insults (e.g., footshock, forced swim, restraint) and a systemic stressor (intraperitoneal interleukin-1beta treatment) likewise provoked a greater rise of plasma corticosterone in the BALB/cByJ mice.	Corticosterone	174-188	interleukin 1 beta	Mus musculus	102-119
11399517-9	2001	In addition, nigericin markedly enhanced the release of IL-1 beta in unprimed mice but not in macrophages from IFN-gamma primed mice.	Nigericin	13-22	interleukin 1 beta	Mus musculus	56-65
11399517-11	2001	Furthermore, treatment with the IL-1 beta converting enzyme (ICE) specific reversible inhibitor YVAD-CHO resulted in a sharp dose- and time-dependent inhibition of IL-1 beta secretion in the serum, whereas the other cytokines were not affected.	tyrosyl-valyl-alanyl-aspartal	96-104	interleukin 1 beta	Mus musculus	32-41
11383749-5	2001	Minocycline- and saline-treated mice subjected to traumatic brain injury were compared with respect to neurological function, lesion volume, and interleukin-1beta production.	Minocycline	0-11	interleukin 1 beta	Mus musculus	145-162
11383749-9	2001	Caspase-1 activity, quantified by measuring mature interleukin-1beta production by enzyme-linked immunosorbent assay, was considerably increased in mice that underwent TBI, and this increase was significantly diminished in minocycline-treated mice.	Minocycline	223-234	interleukin 1 beta	Mus musculus	51-68
11329499-8	2001	RESULTS: Ethanol exposure upregulated basal gene expression of IL-1 beta, TNF-alpha, IL-6, and iNOS in the distal ileum, but similar effects of ethanol on the liver were not observed.	Ethanol	9-16	interleukin 1 beta	Mus musculus	63-72
11290372-4	2001	We also demonstrated that a low dose of Db-cAMP, forskolin or dexamethasone inhibited the production of tumor necrosis factor-alpha and interleukin-1 beta by macrophages stimulated by zymosan.	db-cAMP	40-47	interleukin 1 beta	Mus musculus	136-154
11290372-4	2001	We also demonstrated that a low dose of Db-cAMP, forskolin or dexamethasone inhibited the production of tumor necrosis factor-alpha and interleukin-1 beta by macrophages stimulated by zymosan.	Colforsin	49-58	interleukin 1 beta	Mus musculus	136-154
11290372-4	2001	We also demonstrated that a low dose of Db-cAMP, forskolin or dexamethasone inhibited the production of tumor necrosis factor-alpha and interleukin-1 beta by macrophages stimulated by zymosan.	Dexamethasone	62-75	interleukin 1 beta	Mus musculus	136-154
11290372-4	2001	We also demonstrated that a low dose of Db-cAMP, forskolin or dexamethasone inhibited the production of tumor necrosis factor-alpha and interleukin-1 beta by macrophages stimulated by zymosan.	Zymosan	184-191	interleukin 1 beta	Mus musculus	136-154
11275011-5	2001	Dysidotronic acid inhibited the production of tumor necrosis factor alpha and interleukin-1 beta as well as the production of nitric oxide, prostaglandin E(2) and leukotriene B(4).	dysidotronic acid	0-17	interleukin 1 beta	Mus musculus	78-96
11285013-1	2001	Low doses of lipopolysaccharide, tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), or exposure to a stressor (restraint) increased plasma corticosterone levels.	Corticosterone	162-176	interleukin 1 beta	Mus musculus	95-104
11238717-6	2001	)-induced plasma interleukin-6 peaked at 2 h post injection, which is earlier than the peak time of the Abeta(1-42)-induced brain interleukin-6, tumor necrosis factor-alpha and interleukin-1beta levels, which was 4, 4 and 24 h, respectively.	UNII-042A8N37WH	104-109	interleukin 1 beta	Mus musculus	177-194
11231946-9	2001	Colonic IL-1beta was elevated in DSS-treated MT1-bGH-TG and WT, but IL-1beta mRNA abundance correlated with disease only in WT.	dss	33-36	interleukin 1 beta	Mus musculus	8-16
11094054-2	2001	Treatment of murine macrophages with lipopolysaccharide, interleukin-1beta, and tumor necrosis factor-alpha increased PLAA levels at early time points (2-30 min), which correlated with an up-regulation in cytosolic PLA2 and PGE2 levels.	Dinoprostone	224-228	interleukin 1 beta	Mus musculus	57-74
11174465-4	2001	The results showed that anisodamine significantly suppressed Stx1-induced tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-8 production.	anisodamine	24-35	interleukin 1 beta	Mus musculus	115-132
11181061-5	2001	Both IL-1 beta and (IL-1 beta + IFN-gamma) impaired glucose-stimulated insulin release and reduced the insulin content of wt islets, while (IL-1 beta + IFN-gamma) reduced glucose oxidation rates and cell viability.	Glucose	52-59	interleukin 1 beta	Mus musculus	5-14
11181061-5	2001	Both IL-1 beta and (IL-1 beta + IFN-gamma) impaired glucose-stimulated insulin release and reduced the insulin content of wt islets, while (IL-1 beta + IFN-gamma) reduced glucose oxidation rates and cell viability.	Glucose	52-59	interleukin 1 beta	Mus musculus	20-29
11181061-5	2001	Both IL-1 beta and (IL-1 beta + IFN-gamma) impaired glucose-stimulated insulin release and reduced the insulin content of wt islets, while (IL-1 beta + IFN-gamma) reduced glucose oxidation rates and cell viability.	Glucose	52-59	interleukin 1 beta	Mus musculus	20-29
11181061-6	2001	IL-1 beta exposure to iNOS -/- islets impaired glucose-stimulated insulin release, increased insulin accumulation and reduced the insulin content, without any increase in cell death.	Glucose	47-54	interleukin 1 beta	Mus musculus	0-9
11181061-8	2001	Our data suggest that IL-1 beta may inhibit glucose-stimulated insulin release by pathways that are not NO-dependent and not related to glucose metabolism or cell death.	Glucose	44-51	interleukin 1 beta	Mus musculus	22-31
11161459-0	2001	The modulatory role played by TNF-alpha and IL-1 beta in the inflammatory responses induced by carrageenan in the mouse model of pleurisy.	Carrageenan	95-106	interleukin 1 beta	Mus musculus	44-53
11161459-2	2001	injection of the cytokines TNF-alpha and IL-1beta and their specific antibodies in the early (4 h) and late (48 h) inflammatory responses caused by injection of carrageenan (Cg) into the mouse pleural cavity.	Carrageenan	161-172	interleukin 1 beta	Mus musculus	41-49
11161459-2	2001	injection of the cytokines TNF-alpha and IL-1beta and their specific antibodies in the early (4 h) and late (48 h) inflammatory responses caused by injection of carrageenan (Cg) into the mouse pleural cavity.	Carrageenan	174-176	interleukin 1 beta	Mus musculus	41-49
11161459-3	2001	The antibodies against TNF-alpha and IL-1beta, when injected 30 min prior to Cg, reduced, in a graded and significant manner, both exudation and cell migration in the early (4 h) phase, while they potentiated or had no effect in the late (48 h) phase of Cg response.	Carrageenan	77-79	interleukin 1 beta	Mus musculus	37-45
11161459-3	2001	The antibodies against TNF-alpha and IL-1beta, when injected 30 min prior to Cg, reduced, in a graded and significant manner, both exudation and cell migration in the early (4 h) phase, while they potentiated or had no effect in the late (48 h) phase of Cg response.	Carrageenan	254-256	interleukin 1 beta	Mus musculus	37-45
11161459-6	2001	injection of TNF-alpha or IL-1beta, 5 min prior to Cg, caused graded increase in the exudation of the early (4 h) and late (48 h) phases of the Cg-induced inflammatory responses.	Carrageenan	51-53	interleukin 1 beta	Mus musculus	26-34
11161459-6	2001	injection of TNF-alpha or IL-1beta, 5 min prior to Cg, caused graded increase in the exudation of the early (4 h) and late (48 h) phases of the Cg-induced inflammatory responses.	Carrageenan	144-146	interleukin 1 beta	Mus musculus	26-34
11161459-8	2001	These findings extend previous results and demonstrate that the pro-inflammatory cytokines TNF-alpha and IL-1beta have a critical role in controlling both cell migration and exudation caused by injection of Cg in the mouse pleural cavity.	Carrageenan	207-209	interleukin 1 beta	Mus musculus	105-113
11174465-4	2001	The results showed that anisodamine significantly suppressed Stx1-induced tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-8 production.	anisodamine	24-35	interleukin 1 beta	Mus musculus	134-142
11169027-13	2001	However, secretion of mIL-1beta increased significantly with F6 HPS (80.6%, P &lt; 0.01) as well as with F60S (76.6%, P &lt; 0.02) compared with Cuprophan.	cuprammonium cellulose	145-154	interleukin 1 beta	Mus musculus	22-31
11246703-5	2001	IL-1beta secretion was blocked by the caspase-1 inhibitor, Z-VAD-FMK, indicating that caspase-1 is involved in not only the induction of apoptosis but also the IL-1beta secretion from A. actinomycetemcomitans-infected J774.1 cells.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	59-68	interleukin 1 beta	Mus musculus	0-8
11246703-5	2001	IL-1beta secretion was blocked by the caspase-1 inhibitor, Z-VAD-FMK, indicating that caspase-1 is involved in not only the induction of apoptosis but also the IL-1beta secretion from A. actinomycetemcomitans-infected J774.1 cells.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	59-68	interleukin 1 beta	Mus musculus	160-168
11158262-4	2001	IL-1beta-activated mouse primary astrocytes were treated with 10(-6) M dexamethasone, and IL-1 receptors were studied at the mRNA and protein levels.	Dexamethasone	71-84	interleukin 1 beta	Mus musculus	0-8
11169027-16	2001	Secretion of mIL-1beta is impaired in PD and HD patients treated with Cuprophan.	cuprammonium cellulose	70-79	interleukin 1 beta	Mus musculus	13-22
11169027-17	2001	This impaired ability to secrete active mIL-1beta seems to be independent of ICE activity and is normalized when HD-patients are switched from Cuprophan to low- or high-flux polysulfon.	cuprammonium cellulose	143-152	interleukin 1 beta	Mus musculus	40-49
11169027-17	2001	This impaired ability to secrete active mIL-1beta seems to be independent of ICE activity and is normalized when HD-patients are switched from Cuprophan to low- or high-flux polysulfon.	polysulfon	174-184	interleukin 1 beta	Mus musculus	40-49
11549843-5	2001	Two phosphatidylinositol (PI) 3-kinase-specific inhibitors, wortmannin and LY294002, inhibited IL-1 beta-induced synthesis of PKC-epsilon.	Phosphatidylinositols	4-24	interleukin 1 beta	Mus musculus	95-104
11244300-0	2001	Dorsal and ventral medullary catecholamine cell groups contribute differentially to systemic interleukin-1beta-induced hypothalamic pituitary adrenal axis responses.	Catecholamines	29-42	interleukin 1 beta	Mus musculus	93-110
11244300-2	2001	However, although it is understood that catecholamine inputs are important in initiating mPVN CRH cell responses to IL-1beta, the contributions of distinct brainstem catecholamine cell groups are not known.	Catecholamines	40-53	interleukin 1 beta	Mus musculus	116-124
11244300-5	2001	First we confirmed that PVN 6-hydroxydopamine lesions, which selectively depleted catecholaminergic terminals, significantly reduced IL-1beta-induced mPVN CRH cell activation.	Oxidopamine	28-45	interleukin 1 beta	Mus musculus	133-141
11244300-10	2001	These studies provide novel evidence that both the NTS and VLM catecholamine cells have important, but differential, contributions to the generation of IL-1beta-induced HPA axis responses.	Catecholamines	63-76	interleukin 1 beta	Mus musculus	152-160
11016935-4	2001	In response to ATP, however, pro-IL-1 beta produced by the P2X(7)R(-/-) cells is not externalized or activated by caspase-1.	Adenosine Triphosphate	15-18	interleukin 1 beta	Mus musculus	33-42
11016935-5	2001	Nigericin, an alternate secretion stimulus, promotes release of 17-kDa IL-1 beta from P2X(7)R(-/-) macrophages.	Nigericin	0-9	interleukin 1 beta	Mus musculus	71-80
11549843-5	2001	Two phosphatidylinositol (PI) 3-kinase-specific inhibitors, wortmannin and LY294002, inhibited IL-1 beta-induced synthesis of PKC-epsilon.	Wortmannin	60-70	interleukin 1 beta	Mus musculus	95-104
11549843-5	2001	Two phosphatidylinositol (PI) 3-kinase-specific inhibitors, wortmannin and LY294002, inhibited IL-1 beta-induced synthesis of PKC-epsilon.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	interleukin 1 beta	Mus musculus	95-104
11119551-3	2001	A correlation between the severity of arthritis, the number of GBS in the joints, and local interleukin-6 and interleukin-1beta production was evident.	gbs	63-66	interleukin 1 beta	Mus musculus	110-127
11113291-0	2000	The interaction between IL-1beta and morphine: possible mechanism of the deficiency of morphine-induced analgesia in diabetic mice.	Morphine	87-95	interleukin 1 beta	Mus musculus	24-32
11197748-7	2000	Interleukin-1beta (IL-1beta) production of peritoneal macrophages stimulated by LPS was significantly higher in the bon narine treated group.	narine	120-126	interleukin 1 beta	Mus musculus	0-17
11197748-7	2000	Interleukin-1beta (IL-1beta) production of peritoneal macrophages stimulated by LPS was significantly higher in the bon narine treated group.	narine	120-126	interleukin 1 beta	Mus musculus	19-27
11475007-5	2001	The results revealed that melatonin up-regulated the level of gene expression of transforming growth factor-beta (TGF-beta), macrophage-colony stimulating factor (M-CSF), tumor necrosis factor-alpha (TNF-alpha) and stem cell factor (SCF) in PEC, and the level of gene expression of interleukin-1beta (IL-1beta), M-CSF, TNF-alpha, interferon-gamma (IFN-gamma) and SCF in splenocytes.	Melatonin	26-35	interleukin 1 beta	Mus musculus	282-299
11475007-5	2001	The results revealed that melatonin up-regulated the level of gene expression of transforming growth factor-beta (TGF-beta), macrophage-colony stimulating factor (M-CSF), tumor necrosis factor-alpha (TNF-alpha) and stem cell factor (SCF) in PEC, and the level of gene expression of interleukin-1beta (IL-1beta), M-CSF, TNF-alpha, interferon-gamma (IFN-gamma) and SCF in splenocytes.	Melatonin	26-35	interleukin 1 beta	Mus musculus	301-309
11475007-6	2001	5-Methoxytryptamine augmented the level of gene expression of TGF-beta, M-CSF and SCF in PEC, and the level of gene expression of IL-1beta, TNF-alpha, IFN-gamma, M-CSF and SCF in splenocytes.	5-Methoxytryptamine	0-19	interleukin 1 beta	Mus musculus	130-138
11475007-7	2001	5-Methoxytryptophol elevated the level of gene expression of TNF-alpha, IL-1beta, TGF-beta and M-CSF in PEC, and the level of gene expression of inducible nitric oxide synthase (iNOS), IL-1beta, M-CSF, TNF-alpha, IFN-gamma and SCF in splenocytes.	methoxytryptophol	0-19	interleukin 1 beta	Mus musculus	72-80
11475007-7	2001	5-Methoxytryptophol elevated the level of gene expression of TNF-alpha, IL-1beta, TGF-beta and M-CSF in PEC, and the level of gene expression of inducible nitric oxide synthase (iNOS), IL-1beta, M-CSF, TNF-alpha, IFN-gamma and SCF in splenocytes.	methoxytryptophol	0-19	interleukin 1 beta	Mus musculus	185-193
11113053-7	2000	However, simultaneous addition of IL-1beta, interferon-gamma, and TNF-alpha or the chemokines to cultures resulted in the induction of iNOS, high levels of nitrite, and a marked trypanocidal activity.	Nitrites	156-163	interleukin 1 beta	Mus musculus	34-42
11133345-3	2000	The present study investigated the kinetics and in situ localization of induced IL-1 beta expression in mouse skin following topical exposure to the contact allergen oxazolone.	Oxazolone	166-175	interleukin 1 beta	Mus musculus	80-89
11113291-2	2000	Some factor(s) derived from mononuclear cells, e.g. interleukin-1beta (IL-1beta), may be responsible for the diminished analgesic effect of morphine in diabetic mice.	Morphine	140-148	interleukin 1 beta	Mus musculus	52-69
11133345-6	2000	Following topical exposure of mice to oxazolone for 5-15 min, upregulation of IL-1 beta mRNA was observed in the epidermis, dermis, hair follicles, and sebaceous glands; at 90 min and beyond the pattern of IL-1 beta mRNA expression declined toward control.	Oxazolone	38-47	interleukin 1 beta	Mus musculus	78-87
11113291-2	2000	Some factor(s) derived from mononuclear cells, e.g. interleukin-1beta (IL-1beta), may be responsible for the diminished analgesic effect of morphine in diabetic mice.	Morphine	140-148	interleukin 1 beta	Mus musculus	71-79
11133345-6	2000	Following topical exposure of mice to oxazolone for 5-15 min, upregulation of IL-1 beta mRNA was observed in the epidermis, dermis, hair follicles, and sebaceous glands; at 90 min and beyond the pattern of IL-1 beta mRNA expression declined toward control.	Oxazolone	38-47	interleukin 1 beta	Mus musculus	206-215
11133345-8	2000	Following exposure to oxazolone, cutaneous IL-1 beta protein expression was elevated at 30 min, decreased at 1 h, and fell below the limit of detection of the assay at 2 h before returning to constitutive levels at 4 and 24 h. IL-1 beta protein levels in vehicle-treated mice, naive mice, and mice treated with the respiratory allergen trimellitic anhydride were unchanged over this time period.	Oxazolone	22-31	interleukin 1 beta	Mus musculus	43-52
11113291-10	2000	The diminished analgesic effect of morphine in diabetes was attenuated further with IL-1beta at a dose of 1 ng/mouse (i.c.v.).	Morphine	35-43	interleukin 1 beta	Mus musculus	84-92
11133345-8	2000	Following exposure to oxazolone, cutaneous IL-1 beta protein expression was elevated at 30 min, decreased at 1 h, and fell below the limit of detection of the assay at 2 h before returning to constitutive levels at 4 and 24 h. IL-1 beta protein levels in vehicle-treated mice, naive mice, and mice treated with the respiratory allergen trimellitic anhydride were unchanged over this time period.	Oxazolone	22-31	interleukin 1 beta	Mus musculus	227-236
11113291-11	2000	These results suggest that the decreased analgesic effect of morphine in diabetes may be related to IL-1beta.	Morphine	61-69	interleukin 1 beta	Mus musculus	100-108
11093734-2	2000	Pretreatment with TNF-alpha or interleukin-1beta (IL-1beta), which activated NF-kappaB in the liver, dramatically prevented TNF-alpha-induced liver-cell apoptosis in D-galactosamine (GalN)-sensitized mice, but not anti-Fas antibody-induced hepatotoxicity.	Galactosamine	166-181	interleukin 1 beta	Mus musculus	31-48
11125308-4	2000	However, following stimulation with lipopolysaccharide or phorbol myristate acetate/calcium ionophore, peritoneal cells from H2(b) mice synthesised significantly more IL-1 beta, TNF-alpha, TNFR and IFN-gamma protein and IFN-gamma mRNA than cells from congenic H2(k) or H2(d) mice.	Tetradecanoylphorbol Acetate	58-83	interleukin 1 beta	Mus musculus	167-176
11125308-4	2000	However, following stimulation with lipopolysaccharide or phorbol myristate acetate/calcium ionophore, peritoneal cells from H2(b) mice synthesised significantly more IL-1 beta, TNF-alpha, TNFR and IFN-gamma protein and IFN-gamma mRNA than cells from congenic H2(k) or H2(d) mice.	Calcium	84-91	interleukin 1 beta	Mus musculus	167-176
11093734-2	2000	Pretreatment with TNF-alpha or interleukin-1beta (IL-1beta), which activated NF-kappaB in the liver, dramatically prevented TNF-alpha-induced liver-cell apoptosis in D-galactosamine (GalN)-sensitized mice, but not anti-Fas antibody-induced hepatotoxicity.	Galactosamine	166-181	interleukin 1 beta	Mus musculus	50-58
11093734-2	2000	Pretreatment with TNF-alpha or interleukin-1beta (IL-1beta), which activated NF-kappaB in the liver, dramatically prevented TNF-alpha-induced liver-cell apoptosis in D-galactosamine (GalN)-sensitized mice, but not anti-Fas antibody-induced hepatotoxicity.	Galactosamine	183-187	interleukin 1 beta	Mus musculus	31-48
11093734-2	2000	Pretreatment with TNF-alpha or interleukin-1beta (IL-1beta), which activated NF-kappaB in the liver, dramatically prevented TNF-alpha-induced liver-cell apoptosis in D-galactosamine (GalN)-sensitized mice, but not anti-Fas antibody-induced hepatotoxicity.	Galactosamine	183-187	interleukin 1 beta	Mus musculus	50-58
11192935-6	2000	Cultured lung fibroblasts also express COX-2 activity after stimulation with IL-1beta which is highly sensitive to inhibition with paracetamol.	Acetaminophen	131-142	interleukin 1 beta	Mus musculus	77-85
11146392-11	2000	CX-659S inhibited the expression of mRNA for proinflammatory cytokines IL-1 beta and TNF-alpha in vivo.	CX 659S	0-7	interleukin 1 beta	Mus musculus	71-80
10967106-0	2000	Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma -mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells.	Nitrites	133-140	interleukin 1 beta	Mus musculus	41-58
10967106-5	2000	Inducible nitric oxide synthase mRNA accumulation and nitrite production, which required the simultaneous presence of IL-1beta and IFN-gamma, were also suppressed by approximately 70%, and these cells were more resistant to cytokine-induced apoptosis as compared with parental cells.	Nitrites	54-61	interleukin 1 beta	Mus musculus	118-126
10967106-6	2000	The decrease in glucose-stimulated insulin secretion induced by IL-1beta and IFN-gamma was however not prevented.	Glucose	16-23	interleukin 1 beta	Mus musculus	64-72
11102411-3	2000	Trovafloxacin inhibited the production of tumour necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6 and IL-8 by PBMCs after stimulation with either LPS or LTA by 83%.	trovafloxacin	0-13	interleukin 1 beta	Mus musculus	84-101
11102411-3	2000	Trovafloxacin inhibited the production of tumour necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6 and IL-8 by PBMCs after stimulation with either LPS or LTA by 83%.	trovafloxacin	0-13	interleukin 1 beta	Mus musculus	103-111
11102411-7	2000	Reverse transcription- polymerase chain reaction studies of the mechanisms determining cytokine down-regulation demonstrated that trovafloxacin reduced TNF-alpha, IL-1beta and IL-6 mRNA to levels similar to those of unstimulated cells.	trovafloxacin	130-143	interleukin 1 beta	Mus musculus	163-171
10944484-6	2000	In addition, splenic cytokine mRNA for IL-12 p40, tumor necrosis factor-alpha, and IL-1beta were lower in infected mice fed n-3 PUFA-containing diets than in mice fed the olive oil ethyl esters control diet.	pufa	128-132	interleukin 1 beta	Mus musculus	83-91
11067935-5	2000	Treatment of a mouse macrophage cell line with LPS, synthetic lipid A, IL-2, IL-15, IL-1beta, IFN-gamma, or TNF-alpha significantly increased TLR2 mRNA expression, whereas TLR4 mRNA expression remained constant.	Lipid A	62-69	interleukin 1 beta	Mus musculus	84-92
11342394-5	2000	In a first series of experiments, the possible regulation of corticosterone production by interleukin (IL)-1beta and peripheral catecholamines during restraint was assessed using a pharmacological approach in mice.	Corticosterone	61-75	interleukin 1 beta	Mus musculus	90-112
11342394-11	2000	The present data show that the stress-induced production of corticosterone was modulated by both peripheral catecholamines and IL-1beta.	Corticosterone	60-74	interleukin 1 beta	Mus musculus	127-135
11012620-4	2000	Clarithromycin significantly inhibited the production of IL-1beta and TNF-alpha in the lung (P&lt;0.01).	Clarithromycin	0-14	interleukin 1 beta	Mus musculus	57-65
11040184-8	2000	Anti-IL-16 mAb treatment significantly reduced TNBS-induced weight loss (P&lt; 0.001), mucosal ulceration (P&lt;0.05), myeloperoxidase activity (P&lt; 0.001), and TNBS-mediated increases in mucosal levels of IL-1beta (P&lt;0.05) and tumor necrosis factor alpha (P&lt;0.01).	Trinitrobenzenesulfonic Acid	47-51	interleukin 1 beta	Mus musculus	208-216
10960082-0	2000	Induction of COX-2 and PGE(2) biosynthesis by IL-1beta is mediated by PKC and mitogen-activated protein kinases in murine astrocytes.	Dinoprostone	23-29	interleukin 1 beta	Mus musculus	46-54
10960082-2	2000	In the present study, we examined whether prostaglandin E(2) (PGE(2)) production after IL-1beta stimulation is dependent upon activation of protein kinases in astroglial cells.	Dinoprostone	42-60	interleukin 1 beta	Mus musculus	87-95
10960082-2	2000	In the present study, we examined whether prostaglandin E(2) (PGE(2)) production after IL-1beta stimulation is dependent upon activation of protein kinases in astroglial cells.	Dinoprostone	62-68	interleukin 1 beta	Mus musculus	87-95
10960082-3	2000	Astrocyte cultures stimulated with IL-1beta or the phorbol ester, PMA significantly increased PGE(2) secretion.	Tetradecanoylphorbol Acetate	66-69	interleukin 1 beta	Mus musculus	35-43
10960082-3	2000	Astrocyte cultures stimulated with IL-1beta or the phorbol ester, PMA significantly increased PGE(2) secretion.	Dinoprostone	94-100	interleukin 1 beta	Mus musculus	35-43
10960082-4	2000	The stimulatory action of IL-1beta on PGE(2) production was totally abolished by NS-398, a specific inhibitor of cyclo-oxygenase-2 activity, as well as by the protein synthesis inhibitor cycloheximide, and the glucocorticoid dexamethasone.	Dinoprostone	38-44	interleukin 1 beta	Mus musculus	26-34
10975997-2	2000	We hypothesised that this may be due to the different capacities of the M phis studied commonly (resident, thioglycollate-elicited) to produce prostaglandin E(2)(PGE(2)) and leukotriene B(4)(LTB(4)) which inhibit and stimulate, respectively, tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) production.	Thioglycolates	107-121	interleukin 1 beta	Mus musculus	287-305
10975997-2	2000	We hypothesised that this may be due to the different capacities of the M phis studied commonly (resident, thioglycollate-elicited) to produce prostaglandin E(2)(PGE(2)) and leukotriene B(4)(LTB(4)) which inhibit and stimulate, respectively, tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) production.	Thioglycolates	107-121	interleukin 1 beta	Mus musculus	307-316
11189447-4	2000	The [Ca2+]i inhibitor BAPTA dose dependently inhibited HSP70- but not LPS-induced NF-kappaB activity and subsequent augmentation of proinflammatory cytokine TNF-alpha, IL-1beta, and IL-6 production.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	22-27	interleukin 1 beta	Mus musculus	168-176
10960082-4	2000	The stimulatory action of IL-1beta on PGE(2) production was totally abolished by NS-398, a specific inhibitor of cyclo-oxygenase-2 activity, as well as by the protein synthesis inhibitor cycloheximide, and the glucocorticoid dexamethasone.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	81-87	interleukin 1 beta	Mus musculus	26-34
10960082-4	2000	The stimulatory action of IL-1beta on PGE(2) production was totally abolished by NS-398, a specific inhibitor of cyclo-oxygenase-2 activity, as well as by the protein synthesis inhibitor cycloheximide, and the glucocorticoid dexamethasone.	Cycloheximide	187-200	interleukin 1 beta	Mus musculus	26-34
10960082-4	2000	The stimulatory action of IL-1beta on PGE(2) production was totally abolished by NS-398, a specific inhibitor of cyclo-oxygenase-2 activity, as well as by the protein synthesis inhibitor cycloheximide, and the glucocorticoid dexamethasone.	Dexamethasone	225-238	interleukin 1 beta	Mus musculus	26-34
10960082-7	2000	In that case the expression of the protein remained high at least up to 12 h. Treatment of cells with protein kinase C inhibitors (H-7, bisindolylmaleimide and calphostin C) inhibited IL-1beta stimulation of PGE(2).	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	131-134	interleukin 1 beta	Mus musculus	184-192
10960082-7	2000	In that case the expression of the protein remained high at least up to 12 h. Treatment of cells with protein kinase C inhibitors (H-7, bisindolylmaleimide and calphostin C) inhibited IL-1beta stimulation of PGE(2).	bisindolylmaleimide	136-155	interleukin 1 beta	Mus musculus	184-192
10960082-7	2000	In that case the expression of the protein remained high at least up to 12 h. Treatment of cells with protein kinase C inhibitors (H-7, bisindolylmaleimide and calphostin C) inhibited IL-1beta stimulation of PGE(2).	calphostin C	160-172	interleukin 1 beta	Mus musculus	184-192
10960082-7	2000	In that case the expression of the protein remained high at least up to 12 h. Treatment of cells with protein kinase C inhibitors (H-7, bisindolylmaleimide and calphostin C) inhibited IL-1beta stimulation of PGE(2).	Prostaglandins E	208-211	interleukin 1 beta	Mus musculus	184-192
10960082-9	2000	The ablation of the effects of PMA and IL-1beta on PGE(2) production, likely results from down-regulation of phorbol ester sensitive-PKC isoenzymes.	Prostaglandins E	51-54	interleukin 1 beta	Mus musculus	39-47
10960082-9	2000	The ablation of the effects of PMA and IL-1beta on PGE(2) production, likely results from down-regulation of phorbol ester sensitive-PKC isoenzymes.	Phorbol Esters	109-122	interleukin 1 beta	Mus musculus	39-47
10960082-12	2000	Interestingly, the inhibition of ERK kinase with PD 98059, as well as the inhibition of p38 MAPK with SB 203580, prevented IL-1beta-induced PGE(2) release.	SB 203580	102-111	interleukin 1 beta	Mus musculus	123-131
10960082-12	2000	Interestingly, the inhibition of ERK kinase with PD 98059, as well as the inhibition of p38 MAPK with SB 203580, prevented IL-1beta-induced PGE(2) release.	Prostaglandins E	140-143	interleukin 1 beta	Mus musculus	123-131
10960082-13	2000	ERK1/2 activation by IL-1beta was sensitive to inhibition by the PKC inhibitor bisindolylmaleimide suggesting that ERK phosphorylation is a downstream signal of PKC activation.	bisindolylmaleimide	79-98	interleukin 1 beta	Mus musculus	21-29
10960082-14	2000	These results suggest key roles for PKC as well as for ERK1/2 and p38 MAP kinase cascades in the biosynthesis of PGE(2), likely by regulating the induction of cyclo-oxygenase-2, in IL-1beta-stimulated astroglial cells.	Prostaglandins E	113-116	interleukin 1 beta	Mus musculus	181-189
10884590-6	2000	1 cells, a murine macrophage cell line, was used to study the effects of RA on the production of NO, TNFalpha and IL-1beta.	Tretinoin	73-75	interleukin 1 beta	Mus musculus	114-122
10884590-10	2000	IL-1beta protein production measured by both ELISA and bioassay decreased with RA treatment.	Tretinoin	79-81	interleukin 1 beta	Mus musculus	0-8
11011247-7	2000	RESULTS: TNBS induced severe macroscopic and histologic lesions, with high mucosal MPO, IL-1B and TNFalpha mRNA concentrations.	Trinitrobenzenesulfonic Acid	9-13	interleukin 1 beta	Mus musculus	88-93
10893447-2	2000	We report here an alteration at the complex dinucleotide repeat (TC)n sequence in the interleukin 1-beta gene locus by polymerase chain reaction (PCR)-based assay in mouse melanoma as well as in various cancer cells, which may provide a simple, rapid, non-radioactive screening assay for cancer detection.	Dinucleoside Phosphates	44-56	interleukin 1 beta	Mus musculus	86-104
10934225-3	2000	The B(1) receptor agonist des-Arg(9)bradykinin (DABK), although inactive in saline- or IL-8-treated mice, caused marked neutrophil rolling, adhesion, and emigration 24 h after challenge with IL-1beta (when the cellular response to IL-1beta had subsided).	des-arg	26-33	interleukin 1 beta	Mus musculus	191-199
10934225-3	2000	The B(1) receptor agonist des-Arg(9)bradykinin (DABK), although inactive in saline- or IL-8-treated mice, caused marked neutrophil rolling, adhesion, and emigration 24 h after challenge with IL-1beta (when the cellular response to IL-1beta had subsided).	des-arg	26-33	interleukin 1 beta	Mus musculus	231-239
10945857-5	2000	to CD-1 mice, serum levels of both TNF-alpha and IL-1beta transiently increased, and peaked at 2 h. After the peak responses of TNF-alpha and IL-1beta, serum levels of nitrite and nitrate increased until at least 8 h. Pretreatment of the mice with cerivastatin (20 mg/kg i.p.	Nitrites	168-175	interleukin 1 beta	Mus musculus	49-57
10945857-5	2000	to CD-1 mice, serum levels of both TNF-alpha and IL-1beta transiently increased, and peaked at 2 h. After the peak responses of TNF-alpha and IL-1beta, serum levels of nitrite and nitrate increased until at least 8 h. Pretreatment of the mice with cerivastatin (20 mg/kg i.p.	cerivastatin	248-260	interleukin 1 beta	Mus musculus	49-57
11028556-9	2000	The results indicate that rmIL-10 treatment restores depressed immune response (splenocyte proliferation, IFN-gamma, IL-1beta in males after hemorrhagic shock.	rmil-10	26-33	interleukin 1 beta	Mus musculus	117-125
11011247-9	2000	CONCLUSION: PPARgamma agonist decreases the intensity of TNBS induced colitis through normalization of IL-1B and TNFalpha expression.	Trinitrobenzenesulfonic Acid	57-61	interleukin 1 beta	Mus musculus	103-108
10929076-11	2000	Young mice fed the vitamin E-supplemented diet had significantly lower IL-1beta (day 7) and TNF-alpha production (day 5) compared with those fed the control diet.	Vitamin E	19-28	interleukin 1 beta	Mus musculus	71-79
10871427-11	2000	Sodium selenite at this dose increased the production of proinflammatory cytokines, tumor necrosis factor alpha and interleukin-1 beta, in lipopolysaccharide-stimulated splenic macrophages.	Sodium	0-6	interleukin 1 beta	Mus musculus	116-134
10903769-7	2000	Stimulation of dendritic cells with heparan sulfate induced release of TNF-alpha, IL-1beta, and IL-6, although the maturation of dendritic cells was independent of these cytokines.	Heparitin Sulfate	36-51	interleukin 1 beta	Mus musculus	82-90
10898798-5	2000	By ELISA, MPACs from 10-week-old NODs showed a small but highly significant (p&lt;0.003) increase in IL-1beta and a large significant decrease (p&lt;0.008) in IL-6 compared to 5-week-old NODs.	mpacs	10-15	interleukin 1 beta	Mus musculus	101-109
10936515-0	2000	Dexamethasone inhibits IL-1 beta gene expression in LPS-stimulated RAW 264.7 cells by blocking NF-kappa B/Rel and AP-1 activation.	Dexamethasone	0-13	interleukin 1 beta	Mus musculus	23-32
10899117-2	2000	dsRNA [polyinosinic:polycytidylic acid (poly IC)]-stimulated inducible nitric oxide synthase, interleukin (IL)-1alpha and IL-1beta mRNA expression, nitrite formation and IL-1 release are attenuated in RAW264.7 cells stably expressing dominant negative (dn) mutants of PKR.	Poly C	20-38	interleukin 1 beta	Mus musculus	122-130
10936515-1	2000	In the present study, the mechanism by which dexamethasone (DEX) inhibited IL-1beta gene expression in bacterial lipopolysaccharide (LPS)-activated RAW 264.7 cells was investigated.	Dexamethasone	45-58	interleukin 1 beta	Mus musculus	75-83
10936515-8	2000	We found that the inhibition of IL-1beta production by DEX is not related to p38, which is important in the IL-1beta induction.	Dexamethasone	55-58	interleukin 1 beta	Mus musculus	32-40
10936515-8	2000	We found that the inhibition of IL-1beta production by DEX is not related to p38, which is important in the IL-1beta induction.	Dexamethasone	55-58	interleukin 1 beta	Mus musculus	108-116
10936515-9	2000	These results suggest that DEX may inhibit IL-1beta gene expression by a mechanism involving the blocking of LPS-induced NF-kappaB/Rel and AP-1 activation.	Dexamethasone	27-30	interleukin 1 beta	Mus musculus	43-51
10936515-1	2000	In the present study, the mechanism by which dexamethasone (DEX) inhibited IL-1beta gene expression in bacterial lipopolysaccharide (LPS)-activated RAW 264.7 cells was investigated.	Dexamethasone	60-63	interleukin 1 beta	Mus musculus	75-83
10936515-3	2000	Since the promoter in IL-1beta gene contains binding motifs for NF-kappaB/Rel, AP-1, NF-IL6, and CREB/ATF, which appear to be important in LPS-mediated IL-1beta induction, the effects of DEX on the activation of these transcription factors were examined.	Dexamethasone	187-190	interleukin 1 beta	Mus musculus	22-30
10865171-3	2000	In the RAW cells, IL-1beta, TNF-alpha and prostaglandin E(2) were strongly induced by the OLs and LPS.	N-biotin-C-Co4(mu3-O)4(Py)4(H2O)4-beta-alanine	90-93	interleukin 1 beta	Mus musculus	18-26
10914500-5	2000	In contrast, clasto-lactacystin beta-lactone, a specific inhibitor of the proteasome, caused a dose-dependent stabilization of intracellular pIL-1beta, and this led to a corresponding increase in mIL-1beta and pIL-1beta but not LDH release into culture supernatants.	clasto-lactacystin beta-lactone	13-44	interleukin 1 beta	Mus musculus	196-205
10799447-9	2000	Furthermore, peritoneal macrophages from silicone- and pristane-treated mice produced higher levels of interleukin-1beta (IL-1beta) and IL-6 than those from PBS-treated mice after lipopolysaccharide stimulation.	Silicones	41-49	interleukin 1 beta	Mus musculus	103-120
10835336-9	2000	Cycloheximide pretreatment suggested that hypoxia-induced downregulation of IL-1beta expression did not require de novo protein synthesis.	Cycloheximide	0-13	interleukin 1 beta	Mus musculus	76-84
10828279-8	2000	Chronic As exposures produced 2-10 fold elevation of serum interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha levels, with greater increases seen by repeated injections than by oral exposure, and again, MT-null mice had higher serum cytokines than WT mice after As exposure.	Arsenic	8-10	interleukin 1 beta	Mus musculus	59-76
10799905-10	2000	Finally, PGE2 pretreatment synergistically stimulated LPS-induced expression of IL-1beta and IL-6 genes in mouse macrophages.	Dinoprostone	9-13	interleukin 1 beta	Mus musculus	80-88
10837804-6	2000	We report here that in addition to suppressing iNOS production, 15d-PGJ(2) also decreases the production of tumor necrosis factor alpha (TNFalpha), interleukin-1 beta (IL-1beta) and cyclooxygenase-2 (COX-2) in LPS-stimulated BV-2 microglial cells, thereby acting as a general inhibitor of microglial activation.	15d-pgj	64-71	interleukin 1 beta	Mus musculus	148-166
10837804-6	2000	We report here that in addition to suppressing iNOS production, 15d-PGJ(2) also decreases the production of tumor necrosis factor alpha (TNFalpha), interleukin-1 beta (IL-1beta) and cyclooxygenase-2 (COX-2) in LPS-stimulated BV-2 microglial cells, thereby acting as a general inhibitor of microglial activation.	15d-pgj	64-71	interleukin 1 beta	Mus musculus	168-176
10799447-9	2000	Furthermore, peritoneal macrophages from silicone- and pristane-treated mice produced higher levels of interleukin-1beta (IL-1beta) and IL-6 than those from PBS-treated mice after lipopolysaccharide stimulation.	Silicones	41-49	interleukin 1 beta	Mus musculus	122-130
10799447-9	2000	Furthermore, peritoneal macrophages from silicone- and pristane-treated mice produced higher levels of interleukin-1beta (IL-1beta) and IL-6 than those from PBS-treated mice after lipopolysaccharide stimulation.	pristane	55-63	interleukin 1 beta	Mus musculus	103-120
10799447-9	2000	Furthermore, peritoneal macrophages from silicone- and pristane-treated mice produced higher levels of interleukin-1beta (IL-1beta) and IL-6 than those from PBS-treated mice after lipopolysaccharide stimulation.	pristane	55-63	interleukin 1 beta	Mus musculus	122-130
10768925-7	2000	LPS-stimulated expression of interleukin-1beta and tumor necrosis factor alpha genes in the cells was inhibited by addition of CD14 antisense oligonucleotide.	Oligonucleotides	142-157	interleukin 1 beta	Mus musculus	29-78
10779799-0	2000	Kinetics and mechanism of ATP-dependent IL-1 beta release from microglial cells.	Adenosine Triphosphate	26-29	interleukin 1 beta	Mus musculus	40-49
10779799-3	2000	Addition of extracellular ATP to LPS-primed microglia caused a burst of release of a large amount of processed IL-1 beta.	Adenosine Triphosphate	26-29	interleukin 1 beta	Mus musculus	111-120
10779799-5	2000	In LPS-treated cells, ATP slightly increased the synthesis of pro-IL-1 beta.	Adenosine Triphosphate	22-25	interleukin 1 beta	Mus musculus	66-75
10779799-6	2000	Optimal ATP concentration for IL-1 beta secretion was between 3 and 5 mM, but significant release could be observed at concentrations as low as 1 mM.	Adenosine Triphosphate	8-11	interleukin 1 beta	Mus musculus	30-39
10779799-7	2000	At all ATP concentrations IL-1 beta release could be inhibited by increasing the extracellular K+ concentration.	Adenosine Triphosphate	7-10	interleukin 1 beta	Mus musculus	26-35
10779799-8	2000	ATP-dependent IL-1 beta release was also inhibited by 90 and 60% by the caspase inhibitors YVAD and DEVD, respectively.	Adenosine Triphosphate	0-3	interleukin 1 beta	Mus musculus	14-23
10779799-8	2000	ATP-dependent IL-1 beta release was also inhibited by 90 and 60% by the caspase inhibitors YVAD and DEVD, respectively.	DEVD	100-104	interleukin 1 beta	Mus musculus	14-23
10835296-4	2000	Our results demonstrate that PBN cotreatment prevents the generation of nitrite by RIN-5F cells induced by treatment with tumor necrosis factor-alpha, interleukin 1beta, and interferon-gamma in a dose-dependent fashion.	phenyl-N-tert-butylnitrone	29-32	interleukin 1 beta	Mus musculus	151-168
10752532-4	2000	Exposure of HPMC to acetaldehyde, formaldehyde, glyoxal, methylglyoxal, furaldehyde, but not to 5-hydroxymethyl-furfural, resulted in dose-dependent inhibition of cell growth, viability, and interleukin-1beta (IL-1beta)-stimulated IL-6 release; for several GDP, this suppression was significantly greater compared with L929 cells.	hydroxypropylmethylcellulose-lactose matrix	12-16	interleukin 1 beta	Mus musculus	191-208
10752532-4	2000	Exposure of HPMC to acetaldehyde, formaldehyde, glyoxal, methylglyoxal, furaldehyde, but not to 5-hydroxymethyl-furfural, resulted in dose-dependent inhibition of cell growth, viability, and interleukin-1beta (IL-1beta)-stimulated IL-6 release; for several GDP, this suppression was significantly greater compared with L929 cells.	hydroxypropylmethylcellulose-lactose matrix	12-16	interleukin 1 beta	Mus musculus	210-218
10752532-4	2000	Exposure of HPMC to acetaldehyde, formaldehyde, glyoxal, methylglyoxal, furaldehyde, but not to 5-hydroxymethyl-furfural, resulted in dose-dependent inhibition of cell growth, viability, and interleukin-1beta (IL-1beta)-stimulated IL-6 release; for several GDP, this suppression was significantly greater compared with L929 cells.	Acetaldehyde	20-32	interleukin 1 beta	Mus musculus	191-208
10752532-4	2000	Exposure of HPMC to acetaldehyde, formaldehyde, glyoxal, methylglyoxal, furaldehyde, but not to 5-hydroxymethyl-furfural, resulted in dose-dependent inhibition of cell growth, viability, and interleukin-1beta (IL-1beta)-stimulated IL-6 release; for several GDP, this suppression was significantly greater compared with L929 cells.	Acetaldehyde	20-32	interleukin 1 beta	Mus musculus	210-218
10752532-4	2000	Exposure of HPMC to acetaldehyde, formaldehyde, glyoxal, methylglyoxal, furaldehyde, but not to 5-hydroxymethyl-furfural, resulted in dose-dependent inhibition of cell growth, viability, and interleukin-1beta (IL-1beta)-stimulated IL-6 release; for several GDP, this suppression was significantly greater compared with L929 cells.	Pyruvaldehyde	57-70	interleukin 1 beta	Mus musculus	191-208
10752532-4	2000	Exposure of HPMC to acetaldehyde, formaldehyde, glyoxal, methylglyoxal, furaldehyde, but not to 5-hydroxymethyl-furfural, resulted in dose-dependent inhibition of cell growth, viability, and interleukin-1beta (IL-1beta)-stimulated IL-6 release; for several GDP, this suppression was significantly greater compared with L929 cells.	Pyruvaldehyde	57-70	interleukin 1 beta	Mus musculus	210-218
10752532-4	2000	Exposure of HPMC to acetaldehyde, formaldehyde, glyoxal, methylglyoxal, furaldehyde, but not to 5-hydroxymethyl-furfural, resulted in dose-dependent inhibition of cell growth, viability, and interleukin-1beta (IL-1beta)-stimulated IL-6 release; for several GDP, this suppression was significantly greater compared with L929 cells.	Furaldehyde	72-83	interleukin 1 beta	Mus musculus	191-208
10752532-4	2000	Exposure of HPMC to acetaldehyde, formaldehyde, glyoxal, methylglyoxal, furaldehyde, but not to 5-hydroxymethyl-furfural, resulted in dose-dependent inhibition of cell growth, viability, and interleukin-1beta (IL-1beta)-stimulated IL-6 release; for several GDP, this suppression was significantly greater compared with L929 cells.	Furaldehyde	72-83	interleukin 1 beta	Mus musculus	210-218
10773364-6	2000	STZ induced a low production of interleukin (IL)-2 mRNAs, a mild increase in IL-1alpha and IL-6 mRNAs production, and a dramatic increase in IFN-gamma, IL-1beta, TNF-alpha, IL-12 and IL-2 receptor mRNAs, which correlated with positive PLN responses.	Streptozocin	0-3	interleukin 1 beta	Mus musculus	152-160
10753947-3	2000	Sequential activation with the cytokines IFN-gamma and either tumor necrosis factor-alpha or interleukin-1beta resulted in the induction of iNOS and production of nitrite (20 nM/min) but failed to elicit nitrosation of extracellular 2,3-diaminonapthalene.	Nitrites	163-170	interleukin 1 beta	Mus musculus	93-110
10753947-3	2000	Sequential activation with the cytokines IFN-gamma and either tumor necrosis factor-alpha or interleukin-1beta resulted in the induction of iNOS and production of nitrite (20 nM/min) but failed to elicit nitrosation of extracellular 2,3-diaminonapthalene.	2,3-diaminonaphthalene	233-254	interleukin 1 beta	Mus musculus	93-110
10835296-4	2000	Our results demonstrate that PBN cotreatment prevents the generation of nitrite by RIN-5F cells induced by treatment with tumor necrosis factor-alpha, interleukin 1beta, and interferon-gamma in a dose-dependent fashion.	Nitrites	72-79	interleukin 1 beta	Mus musculus	151-168
10708595-4	2000	Our data clearly demonstrated that in LPS-treated macrophages, cAMP elevator (CTx and 8-bromo-cAMP) could increase IL-1Ra and IL-10 gene expression, while mRNAs of IL-1alpha, IL-12, IL-6, and MIF were decreased and other cytokines like IL-1beta, and IFN-gamma did not give a definite tendency.	camp elevator	63-76	interleukin 1 beta	Mus musculus	236-244
10708595-4	2000	Our data clearly demonstrated that in LPS-treated macrophages, cAMP elevator (CTx and 8-bromo-cAMP) could increase IL-1Ra and IL-10 gene expression, while mRNAs of IL-1alpha, IL-12, IL-6, and MIF were decreased and other cytokines like IL-1beta, and IFN-gamma did not give a definite tendency.	8-Bromo Cyclic Adenosine Monophosphate	86-98	interleukin 1 beta	Mus musculus	236-244
10648469-7	2000	At a dose of 100 mg/kg, NO-aspirin caused a 40%-80% reduction of interleukin (IL)-1beta, IL-12, IL-18, interferon (IFN)-gamma, and tumor necrosis factor alpha production without affecting cytokine messenger RNA expression.	Aspirin	27-34	interleukin 1 beta	Mus musculus	65-87
10683464-1	2000	Porphyromonas gingivalis strain 381 lipid A showed lower activity in inducing interleukin (IL)-1alpha and IL-1beta production and cytokine mRNA expression than synthetic Escherichia coli lipid A (compound 506) in alveolar macrophages of C57BL/6 mice.	Lipid A	36-43	interleukin 1 beta	Mus musculus	106-114
10683464-3	2000	A calmodulin (CaM) antagonist, W-7, inhibited IL-1beta production and its mRNA expression induced by P. gingivalis lipid A but not compound 506 in alveolar macrophages.	Lipid A	115-122	interleukin 1 beta	Mus musculus	46-54
10683495-9	2000	Mice pretreated with 5,7-dihydroxytryptamine to deplete brain serotonin ate less, but, nevertheless, displayed similar hypophagic responses to mIL-1beta or LPS.	5,7-Dihydroxytryptamine	21-44	interleukin 1 beta	Mus musculus	143-152
10808527-1	2000	Involvement of the sphingomyelin cascade in Interleukin 1 beta (IL-1) signal transduction pathway in membrane fraction P2 of the murine brain cortex, was found.	Sphingomyelins	19-32	interleukin 1 beta	Mus musculus	44-62
10808527-2	2000	A key role of the membrane enzyme neutral sphingomyelinase (nSMase) in triggering the sphingomyelin pathway for IL-1 beta, was confirmed.	Sphingomyelins	42-55	interleukin 1 beta	Mus musculus	112-121
10808527-5	2000	It appears that the IL-1 beta effects on the CNS are realized via IL-1 receptor type I and activation of the nSMase as an initiating enzyme of the sphingomyelin cascade.	Sphingomyelins	147-160	interleukin 1 beta	Mus musculus	20-29
10686416-3	2000	Eight hours after LPS injection the DNA binding activity of these complexes is still elevated while induction by IL-1beta returns to baseline levels within 4 h. By immunohistochemistry, using an antibody specific for the tyrosine phosphorylated, activated form of STAT-1, we show that this induction occurs in sensory neurons.	Tyrosine	221-229	interleukin 1 beta	Mus musculus	113-121
10704249-5	2000	These data suggest that nSMase, a key enzyme of the sphingomyelin signal transduction pathway, might be involved in IL-1beta signalling in the brain and that activation of the enzyme requires the IL-1 receptor type 1.	Sphingomyelins	52-65	interleukin 1 beta	Mus musculus	116-124
10841036-0	2000	Dietary docosahexaenoic acid but not eicosapentaenoic acid suppresses lipopolysaccharide-induced interleukin-1 beta mRNA induction in mouse spleen leukocytes.	Docosahexaenoic Acids	8-28	interleukin 1 beta	Mus musculus	97-115
10841036-3	2000	IL-1beta mRNA induction upon lipopolysaccharide (LPS) stimulation in spleen leukocytes in the DHA diet group was significantly lower than in the BT diet group, but the EPA diet was without any significant effect.	Docosahexaenoic Acids	94-97	interleukin 1 beta	Mus musculus	0-8
10841036-3	2000	IL-1beta mRNA induction upon lipopolysaccharide (LPS) stimulation in spleen leukocytes in the DHA diet group was significantly lower than in the BT diet group, but the EPA diet was without any significant effect.	tallow	145-147	interleukin 1 beta	Mus musculus	0-8
10841036-5	2000	Thus, dietary EPA and DHA inhibited arachidonate metabolism similarly but had different effects on IL-1beta mRNA induction in mouse spleen leukocytes.	Eicosapentaenoic Acid	14-17	interleukin 1 beta	Mus musculus	99-107
10841036-5	2000	Thus, dietary EPA and DHA inhibited arachidonate metabolism similarly but had different effects on IL-1beta mRNA induction in mouse spleen leukocytes.	Docosahexaenoic Acids	22-25	interleukin 1 beta	Mus musculus	99-107
10648469-8	2000	NO-aspirin prevented Fas, Fas ligand, and IL-2 receptor up-regulation on spleen lymphocytes and Fas ligand on hepatocytes and caused the S-nitrosylation/inhibition of IL-1beta-converting enzyme-like cysteine proteases (caspases) involved in the processing and maturation of IL-1beta and IL-18.	Aspirin	3-10	interleukin 1 beta	Mus musculus	167-175
10648469-8	2000	NO-aspirin prevented Fas, Fas ligand, and IL-2 receptor up-regulation on spleen lymphocytes and Fas ligand on hepatocytes and caused the S-nitrosylation/inhibition of IL-1beta-converting enzyme-like cysteine proteases (caspases) involved in the processing and maturation of IL-1beta and IL-18.	Aspirin	3-10	interleukin 1 beta	Mus musculus	274-282
10633169-6	2000	These cells modulate the nociceptive response induced by zymosan and acetic acid via release of tumour necrosis factor alpha (TNF-alpha), interleukin 1beta and interleukin 8.	Zymosan	57-64	interleukin 1 beta	Mus musculus	138-155
10714561-2	2000	The present study was designed to characterize the effects of glucoprivation induced by 2-DG administration on concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6 in the blood and interferon-gamma (IFN-gamma), IL-2, and IL-4 in vitro production by partially purified T splenocytes in BDF1 mice.	Deoxyglucose	88-92	interleukin 1 beta	Mus musculus	170-187
10714561-6	2000	The amount of 2-DG injected was associated with an increase in TNF-alpha, IL-1beta, and IL-6 concentrations in the blood of mice after one or three injections of 2-DG (p&lt;0.05).	Deoxyglucose	14-18	interleukin 1 beta	Mus musculus	74-82
10633169-6	2000	These cells modulate the nociceptive response induced by zymosan and acetic acid via release of tumour necrosis factor alpha (TNF-alpha), interleukin 1beta and interleukin 8.	Acetic Acid	69-80	interleukin 1 beta	Mus musculus	138-155
10633169-8	2000	In conclusion, our results suggest that the nociceptive activity of zymosan and acetic acid in the writhing model is due to the release of TNF-alpha, interleukin 1beta and interleukin 8 by resident peritoneal macrophages and mast cells.	Zymosan	68-75	interleukin 1 beta	Mus musculus	150-167
10633169-8	2000	In conclusion, our results suggest that the nociceptive activity of zymosan and acetic acid in the writhing model is due to the release of TNF-alpha, interleukin 1beta and interleukin 8 by resident peritoneal macrophages and mast cells.	Acetic Acid	80-91	interleukin 1 beta	Mus musculus	150-167
10683375-0	2000	IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytes.	ammonium ferrous sulfate	55-58	interleukin 1 beta	Mus musculus	11-19
11213468-3	2000	However, the addition of combinations of these reagents decreased these levels in RAW264.7 cells, but enhanced them in VSMC that had been stimulated with IL-1 beta.	vsmc	119-123	interleukin 1 beta	Mus musculus	154-163
10632101-6	2000	Pups pretreated with interleukin (IL)-1beta, IL-6, IL-9, or tumor necrosis factor-alpha developed significantly larger ibotenate-induced cortical and white matter damage than controls; IL-4 did not produce such an effect.	Ibotenic Acid	119-128	interleukin 1 beta	Mus musculus	21-43
10594073-7	1999	In contrast, the induction of these genes that was quite selective to the cells of the BBB in response to intramuscularly turpentine insult was completely abolished in IL-1beta-deficient mice.	Turpentine	122-132	interleukin 1 beta	Mus musculus	168-176
10695925-8	2000	DHA-Et also decreased the expression of interferon-gamma, interleukin (IL)-6, IL-1beta, and IL-2 mRNA in ears.	dha-et	0-6	interleukin 1 beta	Mus musculus	78-86
10859483-6	2000	The age-related differences in the IL-1beta concentrations in the plasma and hippocampus and [(125)I]IL-1alpha binding in the hippocampus in response to LPS administration were abolished by ODX.	odx	190-193	interleukin 1 beta	Mus musculus	35-43
10859483-10	2000	CONCLUSIONS: Our data suggest the involvement of testosterone (or gonadal product) in plasma and hippocampal IL-1beta regulation in relation to age, and demonstrate the importance of the gonadal development in mediating the effects of infectious challenge on the brain and immune function.	Testosterone	49-61	interleukin 1 beta	Mus musculus	109-117
10623445-7	2000	In contrast, IL-1beta and IL-6 production by Mbeta from young males was suppressed and IL-10 production enhanced following trauma-haemorrhage, whereas Mstraight phi from aged males produced elevated levels of IL-1beta and IL-6 and suppressed levels of IL-10 following trauma-haemorrhage.	mbeta	45-50	interleukin 1 beta	Mus musculus	13-21
10794493-6	2000	In in vivo studies the degree of thymic atrophy and the increases in serum level of ACTH and corticosterone induced by intraperitoneal IL-1beta injection were much less in STR/N mice than those in controls.	Corticosterone	93-107	interleukin 1 beta	Mus musculus	135-143
10594073-9	1999	These results indicate that IL-1beta has an obligatory role in the activation of NF-kappaB molecules and PGs within endothelial cells of the BBB in an experimental model of intramuscularly turpentine-induced inflammation but not during endotoxemia.	Prostaglandins	105-108	interleukin 1 beta	Mus musculus	28-36
10594073-9	1999	These results indicate that IL-1beta has an obligatory role in the activation of NF-kappaB molecules and PGs within endothelial cells of the BBB in an experimental model of intramuscularly turpentine-induced inflammation but not during endotoxemia.	Turpentine	189-199	interleukin 1 beta	Mus musculus	28-36
10497256-6	1999	PGE(2) appears to act primarily at the level of translation or protein stability, because TNF-alpha and IL-6 mRNA levels were only modestly decreased at high PGE(2) concentrations; concomitantly with this inhibition, PGE(2) up-regulated the levels of IL-1beta mRNA.	Prostaglandins E	0-3	interleukin 1 beta	Mus musculus	251-259
12567492-4	1999	MTT method was used to study 10(-9) mol/L-10(-13) mol/L IL-1 beta effect on both normal and adenoma cells growth.	monooxyethylene trimethylolpropane tristearate	0-3	interleukin 1 beta	Mus musculus	56-65
10540190-8	1999	LPS-induced production of IL-1beta was also affected by BZL.	benzonidazole	56-59	interleukin 1 beta	Mus musculus	26-34
10674423-3	1999	Interleukin-1beta- and tumor necrosis factor alpha-immunopositive microglia were localized with thioflavine-positive (fibrillar) Abeta deposits.	thioflavin T	96-107	interleukin 1 beta	Mus musculus	0-17
10600336-6	1999	On the other hand, treatment with linomide significantly increased the levels of IL-1beta (mice and less in rats), IL-6 (rats), and TNF-alpha (mice) in serum samples collected 2 h following injection with LPS.	roquinimex	34-42	interleukin 1 beta	Mus musculus	81-89
10613412-10	1999	In mice fed 500 IU vit-E diets, the serum IL-6, IL-10, IL-12 and TNF-alpha levels were significantly lower and serum IL-1beta was significantly higher compared to 75 IU-vit-E-fed mice in CO/FO or both.	Vitamin E	19-24	interleukin 1 beta	Mus musculus	117-125
10570287-8	1999	RNase-mapping analysis indicated that IL-1alpha, IL-1beta, IL-1Ra, and IL-6 mRNA levels are constitutively elevated in thioglycolate-elicited IkappaBepsilon-null macrophages in contrast to GM-CSF, G-CSF, and IFN-gamma, which remain undetectable.	Thioglycolates	119-132	interleukin 1 beta	Mus musculus	49-57
10612569-1	1999	OBJECTIVE: We previously observed increased expression of interleukin-1beta, platelet-derived growth factor-A, and insulin-like growth factor-I in bronchoalveolar lavage (BAL) cells during the development of pulmonary fibrosis after an intraperitoneal administration of bleomycin in mice.	Bleomycin	270-279	interleukin 1 beta	Mus musculus	58-75
10575665-5	1999	The production of three cytokines, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6, was greater for lipopolysaccharide-stimulated macrophages from mice fed the glutamine-enriched diet.	Glutamine	179-188	interleukin 1 beta	Mus musculus	64-82
10493498-6	1999	A single application of TPA and okadaic acid increased IL-1alpha and IL-1beta gene expression in TNF-/- mice.	Tetradecanoylphorbol Acetate	24-27	interleukin 1 beta	Mus musculus	69-77
10493498-6	1999	A single application of TPA and okadaic acid increased IL-1alpha and IL-1beta gene expression in TNF-/- mice.	Okadaic Acid	32-44	interleukin 1 beta	Mus musculus	69-77
10510443-3	1999	Cyclosporin A and FK506 (at 1 microM) also significantly inhibited nitrite production induced by recombinant murine interferon-gamma (rIFNgamma) and recombinant murine interleukin-1beta (rIL-1beta) in J774 and VSMC, respectively.	Cyclosporine	0-13	interleukin 1 beta	Mus musculus	168-185
10484338-0	1999	Endotoxin-mediated nitric oxide synthesis inhibits IL-1beta gene transcription in ANA-1 murine macrophages.	Nitric Oxide	19-31	interleukin 1 beta	Mus musculus	51-59
10484338-1	1999	On the basis of previous work demonstrating nitric oxide (NO)-mediated inhibition of nuclear factor-kappaB (NF-kappaB) DNA binding, we hypothesized that NO downregulates NF-kappaB-dependent interleukin-1beta (IL-1beta) production in an ANA-1 macrophage model of lipopolysaccharide (LPS) stimulation.	Nitric Oxide	44-56	interleukin 1 beta	Mus musculus	190-207
10484338-1	1999	On the basis of previous work demonstrating nitric oxide (NO)-mediated inhibition of nuclear factor-kappaB (NF-kappaB) DNA binding, we hypothesized that NO downregulates NF-kappaB-dependent interleukin-1beta (IL-1beta) production in an ANA-1 macrophage model of lipopolysaccharide (LPS) stimulation.	Nitric Oxide	44-56	interleukin 1 beta	Mus musculus	209-217
10484338-6	1999	Repletion of NO by addition of an S-nitrosothiol restored IL-1beta protein synthesis, mRNA levels, gene transcription, promoter activity, and NF-kappaB DNA binding to levels noted in the presence of LPS alone.	S-Nitrosothiols	34-48	interleukin 1 beta	Mus musculus	58-66
10477606-7	1999	Although activation of BMCMC induced the expression of mRNAs for the inflammatory cytokines IL-1beta, IL-4, IL-6, TNF-alpha, and the chemokine lymphotactin, mRNAs for IL-1beta, TNF-alpha, and lymphotactin were down-modulated in the presence of alpha-MSH.	bmcmc	23-28	interleukin 1 beta	Mus musculus	92-100
10477606-7	1999	Although activation of BMCMC induced the expression of mRNAs for the inflammatory cytokines IL-1beta, IL-4, IL-6, TNF-alpha, and the chemokine lymphotactin, mRNAs for IL-1beta, TNF-alpha, and lymphotactin were down-modulated in the presence of alpha-MSH.	bmcmc	23-28	interleukin 1 beta	Mus musculus	167-175
10510443-3	1999	Cyclosporin A and FK506 (at 1 microM) also significantly inhibited nitrite production induced by recombinant murine interferon-gamma (rIFNgamma) and recombinant murine interleukin-1beta (rIL-1beta) in J774 and VSMC, respectively.	Tacrolimus	18-23	interleukin 1 beta	Mus musculus	168-185
10510443-3	1999	Cyclosporin A and FK506 (at 1 microM) also significantly inhibited nitrite production induced by recombinant murine interferon-gamma (rIFNgamma) and recombinant murine interleukin-1beta (rIL-1beta) in J774 and VSMC, respectively.	Nitrites	67-74	interleukin 1 beta	Mus musculus	168-185
10499156-2	1999	Changes in the content of striatal interleukins (IL-1 beta and IL-6) and serum corticosterone in relation to deterioration of the dopaminergic system induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; a dopaminergic neurotoxin; 20 mg/kg i.p., four administrations/12 h) in C57BL/6J mice were investigated.	1-phenyl-1,2,3,6-tetrahydropyridine	172-205	interleukin 1 beta	Mus musculus	49-58
10530874-2	1999	We show here, by using mouse macrophages in primary culture, that pre-treatment with dexamethasone inhibits bacteria-induced IL-1beta expression as mRNA and cellular pro-IL-1beta in parallel, consistent with an effect primarily on transcriptional activation.	Dexamethasone	85-98	interleukin 1 beta	Mus musculus	125-133
10530874-2	1999	We show here, by using mouse macrophages in primary culture, that pre-treatment with dexamethasone inhibits bacteria-induced IL-1beta expression as mRNA and cellular pro-IL-1beta in parallel, consistent with an effect primarily on transcriptional activation.	Dexamethasone	85-98	interleukin 1 beta	Mus musculus	170-178
10441776-6	1999	Noni-ppt was also capable of stimulating the release of several mediators from murine effector cells, including tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-10, IL-12 p70, interferon-gamma (IFN-gamma) and nitric oxide (NO), but had no effect on IL-2 and suppressed IL-4 release.	noni-ppt	0-8	interleukin 1 beta	Mus musculus	154-171
10479401-9	1999	When tested with the 314 bp LIF-promoter construct, incubation of stromal cells with IL-1beta (500 U/ml) resulted in a 1.57-fold stimulation, with TNF-alpha (500 U/ml) in 2.06-fold stimulation, and with 8BrcAMP (0.5 mM) in a 3.	8-Bromo Cyclic Adenosine Monophosphate	203-210	interleukin 1 beta	Mus musculus	85-93
10464143-0	1999	Interleukin 1beta protects mice from Fas-mediated hepatocyte apoptosis and death.	ammonium ferrous sulfate	37-40	interleukin 1 beta	Mus musculus	0-17
10464143-2	1999	The aim of this study was to determine whether interleukin (IL)-1beta regulates the Fas-mediated apoptotic process of differentiated hepatocytes in vivo.	ammonium ferrous sulfate	84-87	interleukin 1 beta	Mus musculus	47-69
10464143-7	1999	IL-1beta affected neither hepatic distribution of anti-Fas antibody nor Fas expression levels on hepatocytes but significantly suppressed Fas-induced activation of hepatic caspase 3-like protease.	ammonium ferrous sulfate	55-58	interleukin 1 beta	Mus musculus	0-8
10464143-8	1999	Suppression of Fas-induced activation of the caspase by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine.	ammonium ferrous sulfate	15-18	interleukin 1 beta	Mus musculus	56-64
10464143-8	1999	Suppression of Fas-induced activation of the caspase by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine.	Galactosamine	105-120	interleukin 1 beta	Mus musculus	56-64
10464143-8	1999	Suppression of Fas-induced activation of the caspase by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine.	Uridine	174-181	interleukin 1 beta	Mus musculus	56-64
10464143-9	1999	CONCLUSIONS: These results suggest that IL-1beta suppresses Fas-mediated hepatocyte apoptosis by inducing molecule(s) that suppress the apoptosis control machinery upstream of caspase 3.	ammonium ferrous sulfate	60-63	interleukin 1 beta	Mus musculus	40-48
10495773-8	1999	Cd produced dose- and time-dependent increases in neutrophils (7x), along with a marked elevation of serum IL-1 beta (6x) and TNF-alpha (20x) levels.	Cadmium	0-2	interleukin 1 beta	Mus musculus	107-116
10419885-0	1999	Hyaluronate-enhanced hematopoiesis: two different receptors trigger the release of interleukin-1beta and interleukin-6 from bone marrow macrophages.	hyaluronate	0-11	interleukin 1 beta	Mus musculus	83-100
10426794-6	1999	Interleukin (IL)-1beta production of peritoneal macrophages in the auraptene-treated mice at all doses was significantly higher than that in the control group (P &lt; 0.05-0.001).	aurapten	67-76	interleukin 1 beta	Mus musculus	0-22
10433805-4	1999	In RIN5F cells, the activity of iNOS induced by IL-1beta (10 pM, 24 h), was significantly reduced by glucagon (1000 nM), which raises cyclic AMP, and by forskolin (1-10 microM), a non specific activator of adenylate cyclase.	Glucagon	101-109	interleukin 1 beta	Mus musculus	48-56
10433805-4	1999	In RIN5F cells, the activity of iNOS induced by IL-1beta (10 pM, 24 h), was significantly reduced by glucagon (1000 nM), which raises cyclic AMP, and by forskolin (1-10 microM), a non specific activator of adenylate cyclase.	Cyclic AMP	134-144	interleukin 1 beta	Mus musculus	48-56
10433805-4	1999	In RIN5F cells, the activity of iNOS induced by IL-1beta (10 pM, 24 h), was significantly reduced by glucagon (1000 nM), which raises cyclic AMP, and by forskolin (1-10 microM), a non specific activator of adenylate cyclase.	Colforsin	153-162	interleukin 1 beta	Mus musculus	48-56
10477397-1	1999	Combinations of cytokines, including interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma), induce nitric oxide (NO) production and cell death in pancreatic islet cells.	Nitric Oxide	107-119	interleukin 1 beta	Mus musculus	37-54
10477397-1	1999	Combinations of cytokines, including interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma), induce nitric oxide (NO) production and cell death in pancreatic islet cells.	Nitric Oxide	107-119	interleukin 1 beta	Mus musculus	56-64
10477397-6	1999	Following a 24 hours exposure to IL-1beta or IL-1beta + IFN-gamma, pancreatic islets isolated from IRF-1-/- mice presented a 30-50% reduction in medium nitrite accumulation and inducible NO-synthase (iNOS) expression.	Nitrites	152-159	interleukin 1 beta	Mus musculus	33-41
10477397-6	1999	Following a 24 hours exposure to IL-1beta or IL-1beta + IFN-gamma, pancreatic islets isolated from IRF-1-/- mice presented a 30-50% reduction in medium nitrite accumulation and inducible NO-synthase (iNOS) expression.	Nitrites	152-159	interleukin 1 beta	Mus musculus	45-53
10453013-12	1999	Synergistic activation of the IL-1beta promoter by these IRF proteins and PU.1 was found to require PU.1 serine 148.	Serine	105-111	interleukin 1 beta	Mus musculus	30-38
10413302-1	1999	We previously demonstrated that the addition of proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma) caused induction of mRNAs for inducible nitric oxide (NO) synthase and GTP cyclohydrolase I, a rate-limiting enzyme for 5,6,7,8-tetrahydrobiopterin (BH4) biosynthesis, and produced their end-products, NO and BH4, in osteoblastic cells.	Nitric Oxide	185-197	interleukin 1 beta	Mus musculus	104-121
10413302-1	1999	We previously demonstrated that the addition of proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma) caused induction of mRNAs for inducible nitric oxide (NO) synthase and GTP cyclohydrolase I, a rate-limiting enzyme for 5,6,7,8-tetrahydrobiopterin (BH4) biosynthesis, and produced their end-products, NO and BH4, in osteoblastic cells.	sapropterin	265-292	interleukin 1 beta	Mus musculus	104-121
10413302-1	1999	We previously demonstrated that the addition of proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma) caused induction of mRNAs for inducible nitric oxide (NO) synthase and GTP cyclohydrolase I, a rate-limiting enzyme for 5,6,7,8-tetrahydrobiopterin (BH4) biosynthesis, and produced their end-products, NO and BH4, in osteoblastic cells.	sapropterin	294-297	interleukin 1 beta	Mus musculus	104-121
10413302-1	1999	We previously demonstrated that the addition of proinflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma) caused induction of mRNAs for inducible nitric oxide (NO) synthase and GTP cyclohydrolase I, a rate-limiting enzyme for 5,6,7,8-tetrahydrobiopterin (BH4) biosynthesis, and produced their end-products, NO and BH4, in osteoblastic cells.	sapropterin	353-356	interleukin 1 beta	Mus musculus	104-121
10668636-8	1999	Testosterone and 17beta-estradiol inhibited IL-1beta mRNA expression only in cells derived from young mice.	Testosterone	0-12	interleukin 1 beta	Mus musculus	44-52
10668636-8	1999	Testosterone and 17beta-estradiol inhibited IL-1beta mRNA expression only in cells derived from young mice.	Estradiol	17-33	interleukin 1 beta	Mus musculus	44-52
10462192-8	1999	Mice in which cerebral norepinephrine was depleted with DSP-4 or 6-hydroxydopamine also displayed the usual hypophagia in response to mIL-1beta and LPS.	Norepinephrine	23-37	interleukin 1 beta	Mus musculus	134-143
10462192-8	1999	Mice in which cerebral norepinephrine was depleted with DSP-4 or 6-hydroxydopamine also displayed the usual hypophagia in response to mIL-1beta and LPS.	Oxidopamine	65-82	interleukin 1 beta	Mus musculus	134-143
10441776-6	1999	Noni-ppt was also capable of stimulating the release of several mediators from murine effector cells, including tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-10, IL-12 p70, interferon-gamma (IFN-gamma) and nitric oxide (NO), but had no effect on IL-2 and suppressed IL-4 release.	noni-ppt	0-8	interleukin 1 beta	Mus musculus	173-181
10419651-0	1999	Interleukin 1beta mediates the effect of high D-glucose on the secretion of TNF-alpha by mouse uterine epithelial cells.	Glucose	46-55	interleukin 1 beta	Mus musculus	0-17
10383397-2	1999	Previously we reported that 3-deazaadenosine (DZA), a potent inhibitor and substrate for S-adenosylhomocysteine hydrolase inhibits bacterial lipopolysaccharide-induced transcription of tumor necrosis factor-alpha and interleukin-1beta in mouse macrophage RAW 264.7 cells.	3-deazaadenosine	28-44	interleukin 1 beta	Mus musculus	217-234
10383397-2	1999	Previously we reported that 3-deazaadenosine (DZA), a potent inhibitor and substrate for S-adenosylhomocysteine hydrolase inhibits bacterial lipopolysaccharide-induced transcription of tumor necrosis factor-alpha and interleukin-1beta in mouse macrophage RAW 264.7 cells.	3-deazaadenosine	46-49	interleukin 1 beta	Mus musculus	217-234
10391869-3	1999	Stimulation of PBMCs by SEB or TSST-1 was effectively blocked by pentoxifylline (10 mM), as evidenced by the inhibition of TNF-alpha, interleukin 1beta (IL-1beta), gamma interferon (IFN-gamma), and T-cell proliferation.	Pentoxifylline	65-79	interleukin 1 beta	Mus musculus	134-151
10391869-3	1999	Stimulation of PBMCs by SEB or TSST-1 was effectively blocked by pentoxifylline (10 mM), as evidenced by the inhibition of TNF-alpha, interleukin 1beta (IL-1beta), gamma interferon (IFN-gamma), and T-cell proliferation.	Pentoxifylline	65-79	interleukin 1 beta	Mus musculus	153-161
10389841-7	1999	The ceramide effect on cell viability mimicked the effect of the cytokines TNF-alpha, IL-1beta, and IFN-gamma, reported stimulators of sphingomyelin hydrolysis.	Ceramides	4-12	interleukin 1 beta	Mus musculus	86-94
10389841-7	1999	The ceramide effect on cell viability mimicked the effect of the cytokines TNF-alpha, IL-1beta, and IFN-gamma, reported stimulators of sphingomyelin hydrolysis.	Sphingomyelins	135-148	interleukin 1 beta	Mus musculus	86-94
10419651-5	1999	Macrophages of the RAW 264.7 cell line were found to secrete more interleukin (IL)-1beta (but not TNF-alpha) when cultured in high D-glucose.	Glucose	131-140	interleukin 1 beta	Mus musculus	66-88
10362533-3	1999	IL-1beta (5 ng/ml, 24h) also induced significant binding to [3H]-des-Arg10-kallidin with a dissociation constant (Kd) of 2.95 nM and a maximal binding density (Bmax) of 670 sites/cell.	Tritium	61-63	interleukin 1 beta	Mus musculus	0-8
10393514-7	1999	IL-1beta levels in the hippocampus, hypothalamus, adrenal gland and plasma were elevated to comparable levels in the saline-LPS and LPS-LPS groups after 4 days of treatment.	Sodium Chloride	117-123	interleukin 1 beta	Mus musculus	0-8
10393514-9	1999	Increases in IL-1beta concentrations were seen in all tissues following one endotoxin challenge in the saline-LPS group following the 8-day treatment regimen, while increases were significantly attenuated in the hypothalamus, adrenal gland and plasma in LPS-LPS for 8 days.	Sodium Chloride	103-109	interleukin 1 beta	Mus musculus	13-21
10393514-10	1999	The sustained increases in tissue levels of IL-1beta following 4-day endotoxin treatment appears to have functional consequences since [125I]IL-1alpha binding was significantly decreased in the LPS-saline group compared with the saline-saline group.	Sodium Chloride	198-204	interleukin 1 beta	Mus musculus	44-52
10393514-10	1999	The sustained increases in tissue levels of IL-1beta following 4-day endotoxin treatment appears to have functional consequences since [125I]IL-1alpha binding was significantly decreased in the LPS-saline group compared with the saline-saline group.	Sodium Chloride	229-235	interleukin 1 beta	Mus musculus	44-52
10393514-10	1999	The sustained increases in tissue levels of IL-1beta following 4-day endotoxin treatment appears to have functional consequences since [125I]IL-1alpha binding was significantly decreased in the LPS-saline group compared with the saline-saline group.	Sodium Chloride	229-235	interleukin 1 beta	Mus musculus	44-52
10373405-7	1999	Furthermore, we demonstrated the increased expression of the two NF-kappaB target genes IL-6 and IL-1beta in OAA-exposed mice and a transient OAA-induced accumulation of TNFalpha in vitro.	oleoylanilide	109-112	interleukin 1 beta	Mus musculus	97-105
10501514-0	1999	Glycerol-induced seizure: involvement of IL-1beta and glutamate.	Glycerol	0-8	interleukin 1 beta	Mus musculus	41-49
10501514-6	1999	These results are consistent with previous data suggesting a modulatory effect of IL-1beta on glutamate release in hippocampus.	Glutamic Acid	94-103	interleukin 1 beta	Mus musculus	82-90
10362533-4	1999	Des-Arg10-kallidin (10 microM), a BDKRB1 agonist, increased intracellular calcium ion ([Ca2+]i) in IL-1beta (5 ng/ml, 24 h)-exposed cells, an increase not observed in the cells not exposed to IL-1beta.	Calcium	74-81	interleukin 1 beta	Mus musculus	99-107
10386913-8	1999	However, compared to age-matched PBS controls, centrally administered IL-1beta depressed food intake more in aged mice than in adults.	Lead	33-36	interleukin 1 beta	Mus musculus	70-78
10342859-11	1999	Collectively, these data demonstrate that COX-2, but not COX-1, is required for the gonadotropin induction of ovarian PG levels; that COX-2-related prostanoids are required for stabilization of the cumulus oophorum during ovulation; and that ovulation can be restored in the COX-2(-/-) animals by simultaneous treatment with gonadotropins and PGE2 or interleukin-1beta.	Prostaglandins	148-159	interleukin 1 beta	Mus musculus	351-368
10442858-7	1999	DEM completely inhibited an increase of serum IL-1beta level by LPS, whereas BSO failed to inhibit it.	diethyl maleate	0-3	interleukin 1 beta	Mus musculus	46-54
10330034-3	1999	Treatment with lisofylline inhibited hyperoxia-associated increases in tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 in the lungs as well as decreased the levels of hyperoxia-induced serum-oxidized free fatty acids.	lisofylline	15-26	interleukin 1 beta	Mus musculus	100-117
10320804-7	1999	In PLA2-IIA-deficient mice, indoxam also suppressed the elevation of plasma IL-1beta, IL-6 and NO, and prolonged survival after LPS challenge.	indoxam	28-35	interleukin 1 beta	Mus musculus	76-84
10228013-2	1999	In this study, we examined the role of p38 MAPK in the regulation of the IL-1beta cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580.	imidazole	139-148	interleukin 1 beta	Mus musculus	73-81
10210733-6	1999	Pretreatment of RAW 264 macrophages with alendronate augmented the LPS-stimulated release of IL-1beta and increased the binding of NF-kappaB to DNA in an electrophoretic mobility shift assay.	Alendronate	41-52	interleukin 1 beta	Mus musculus	93-101
10410269-10	1999	Stimulation with CM increased nitrite production in 3T3 fibroblasts, which was significantly inhibited by antibodies against interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and iNOS inhibitor, L-NMMA.	Nitrites	30-37	interleukin 1 beta	Mus musculus	125-143
10410269-10	1999	Stimulation with CM increased nitrite production in 3T3 fibroblasts, which was significantly inhibited by antibodies against interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and iNOS inhibitor, L-NMMA.	Nitrites	30-37	interleukin 1 beta	Mus musculus	145-154
10228013-2	1999	In this study, we examined the role of p38 MAPK in the regulation of the IL-1beta cytokine gene in monocytic cell lines using the bicyclic imidazole SB203580.	SB 203580	149-157	interleukin 1 beta	Mus musculus	73-81
10228013-3	1999	Addition of SB203580 30 min before stimulation of monocytes with LPS inhibited IL-1beta protein and steady state message in a dose-dependent manner in both RAW264.7 and J774 cell lines.	SB 203580	12-20	interleukin 1 beta	Mus musculus	79-87
10102685-3	1999	Exposure of islets isolated from C57BL/6 mice to IL-1beta for 24 h in vitro resulted in an induction of iNOS mRNA expression, an increase in nitrite formation, and a decrease in insulin release and proinsulin biosynthesis as compared with untreated C57BL/6 islets.	Nitrites	141-148	interleukin 1 beta	Mus musculus	49-57
10428652-5	1999	In contrast, LC migration provoked by similar exposure of mice to IL-1beta (the action of which is dependent upon the de novo synthesis of TNF-alpha) was inhibited by DEX as was the arrival of DC in draining lymph nodes induced by this cytokine.	Dexamethasone	167-170	interleukin 1 beta	Mus musculus	66-74
10194539-2	1999	IL-1beta is released by activated macrophages resident within islets, and its cytotoxic actions include a stimulation of nitric oxide (NO) production and the initiation of apoptosis.	Nitric Oxide	121-133	interleukin 1 beta	Mus musculus	0-8
10344468-12	1999	Bone resorption stimulated by conditioned media from zymosan treated macrophages after 3 h was inhibited by 60-75% in the presence of anti IL-1alpha, 0-20% by anti IL-1beta, and completely by antisera neutralizing both IL-1alpha and IL-1beta.	Zymosan	53-60	interleukin 1 beta	Mus musculus	164-172
10344468-12	1999	Bone resorption stimulated by conditioned media from zymosan treated macrophages after 3 h was inhibited by 60-75% in the presence of anti IL-1alpha, 0-20% by anti IL-1beta, and completely by antisera neutralizing both IL-1alpha and IL-1beta.	Zymosan	53-60	interleukin 1 beta	Mus musculus	233-241
10067824-13	1999	Treatment of Leydig cells with 0.2 ng/ml interleukin-1beta inhibited (Bu)2cAMP-induced EST expression, which was overcome by the addition of 5-DHT.	Dihydrotestosterone	141-146	interleukin 1 beta	Mus musculus	41-58
10066912-9	1999	injection of IL-1beta; (ii) significantly greater increases in body temperature and physical activity after i. p. saline; and (iii) a significantly greater hyperthermia (but a similar increase in activity) during cage-switch stress.	Sodium Chloride	114-120	interleukin 1 beta	Mus musculus	13-21
10452106-0	1999	Inhibitory effects of nitric oxide and interleukin-10 on production of tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 in mouse alveolar macrophages.	Nitric Oxide	22-34	interleukin 1 beta	Mus musculus	100-118
10088668-3	1999	In this report, we describe the sequential effects of IL-4 and IL-10 on the production of interleukin-6 (IL-6) induced by IL-1beta in mouse primary astrocytes and compare these effects to those of the synthetic glucocorticoid agonist, dexamethasone.	Dexamethasone	235-248	interleukin 1 beta	Mus musculus	122-130
10088668-9	1999	Therefore, we conclude that IL-10 and dexamethasone have rapid immunosuppressive effects on the astrocyte response to IL-1beta stimulation, whereas IL-4, which has a delayed action, acts as an immune inducer.	Dexamethasone	38-51	interleukin 1 beta	Mus musculus	118-126
10024595-4	1999	Preinjection of mice with anti-murine TNF-alpha (anti-mTNF-alpha) or anti-murine IL-1beta (anti-mIL-1beta) 30 min prior to administration of Shigella sonicate abolished their enhanced response to PTZ at 7 h. Mean convulsion scores were reduced by anti-mTNF-alpha from 1.2 to 0.8 (P = 0.017) and by anti-mIL-1beta from 1.3 to 0.7 (P = 0.008).	Pentylenetetrazole	196-199	interleukin 1 beta	Mus musculus	81-89
10024595-4	1999	Preinjection of mice with anti-murine TNF-alpha (anti-mTNF-alpha) or anti-murine IL-1beta (anti-mIL-1beta) 30 min prior to administration of Shigella sonicate abolished their enhanced response to PTZ at 7 h. Mean convulsion scores were reduced by anti-mTNF-alpha from 1.2 to 0.8 (P = 0.017) and by anti-mIL-1beta from 1.3 to 0.7 (P = 0.008).	Pentylenetetrazole	196-199	interleukin 1 beta	Mus musculus	96-105
10452106-5	1999	SMT inhibited LPS-induced nitric oxide release and increased IL-1 beta and IL-6 secretions in AM, but the TNF alpha levels remained unchanged.	S-Methylisothiourea hemisulfate	0-3	interleukin 1 beta	Mus musculus	61-70
10452106-8	1999	CONCLUSION: Both endogenous and exogenous nitric oxide and IL-10 had inhibitory effects on the LPS-induced TNF alpha, IL-1 beta, and IL-6 secretions in mouse AM.	Nitric Oxide	42-54	interleukin 1 beta	Mus musculus	118-127
9949322-8	1999	By using an in vivo approach, sensitization of the skin with trinitrochlorbenzene, but not with ovalbumin, resulted in an early induction of IL-1beta, IL-12p40, and IFN-gamma mRNA in LNCs, whereas IL-18 was induced by both.	trinitrochlorbenzene	61-81	interleukin 1 beta	Mus musculus	141-149
10208603-0	1999	Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	109-113	interleukin 1 beta	Mus musculus	54-71
9989930-2	1999	IL-1beta and TNF-alpha inhibited insulin release and glucose utilization and oxidation.	Glucose	53-60	interleukin 1 beta	Mus musculus	0-8
9989930-5	1999	On the other hand, nitric oxide was a factor of the deleterious effects of IL-1beta, TNF-alpha, and ST on pancreatic islets.	Nitric Oxide	19-31	interleukin 1 beta	Mus musculus	75-83
9880559-2	1999	Ceramide and ceramide-activated enzymes have been implicated in responses to bacterial lipopolysaccharide (LPS) and the proinflammatory cytokines tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1).	Ceramides	0-8	interleukin 1 beta	Mus musculus	184-201
10075017-3	1999	When cocultured with IL-1beta, TGF-beta showed growth-promoting activity that could be antagonized by adding the phosphatidyl choline-dependent phospholipase C (PC-PLC) inhibitor, D609.	Phosphatidylcholines	113-133	interleukin 1 beta	Mus musculus	21-29
10075017-3	1999	When cocultured with IL-1beta, TGF-beta showed growth-promoting activity that could be antagonized by adding the phosphatidyl choline-dependent phospholipase C (PC-PLC) inhibitor, D609.	tricyclodecane-9-yl-xanthogenate	180-184	interleukin 1 beta	Mus musculus	21-29
9880559-2	1999	Ceramide and ceramide-activated enzymes have been implicated in responses to bacterial lipopolysaccharide (LPS) and the proinflammatory cytokines tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1).	Ceramides	13-21	interleukin 1 beta	Mus musculus	184-201
9987822-4	1999	Compound 27c also dose dependently inhibited LPS-primed ATP-induced IL-1 beta release in mice.	Adenosine Triphosphate	56-59	interleukin 1 beta	Mus musculus	68-77
9887049-5	1999	Administration of the alpha-adrenergic antagonist phentolamine before endotoxemia did not alter lung neutrophil accumulation as measured by myeloperoxidase (MPO) levels but did result in significant increases in IL-1beta, TNF-alpha, and MIP-2 mRNA expression by lung neutrophils compared with endotoxemia alone.	Phentolamine	50-62	interleukin 1 beta	Mus musculus	212-220
9878816-0	1999	The role of interleukin-6 in the activation of the hypothalamo-pituitary-adrenocortical axis and brain indoleamines by endotoxin and interleukin-1 beta.	indolamine	103-115	interleukin 1 beta	Mus musculus	133-151
9914554-2	1999	We investigated the effects of the cytochrome P450 pathway in IL-1beta-induced calcium release from cultured mouse calvaria in vitro in the presence of clotrimazole, a cytochrome P450 inhibitor, or L-N(G)-arginine methyl ester, a nitric oxide synthase inhibitor.	Calcium	79-86	interleukin 1 beta	Mus musculus	62-70
10072717-7	1999	Verapamil treatment reduced the expression of cardiac NOS2 protein and the mRNAs for NOS2, TNF-alpha, and IL-1beta.	Verapamil	0-9	interleukin 1 beta	Mus musculus	106-114
10704073-1	1999	This study was designed to examine the influence of a macrolide antibiotic, roxithromycin (RXM), on the production of pro-inflammatory cytokines, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha.	Macrolides	54-63	interleukin 1 beta	Mus musculus	146-168
10704073-1	1999	This study was designed to examine the influence of a macrolide antibiotic, roxithromycin (RXM), on the production of pro-inflammatory cytokines, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha.	Roxithromycin	76-89	interleukin 1 beta	Mus musculus	146-168
9987683-10	1999	Of great interest, treatment of CIA with prednisolone/IL-10 markedly reduced IL-1 beta and enhanced IL-10 production by synovial tissue.	Prednisolone	41-53	interleukin 1 beta	Mus musculus	77-86
10503944-11	1999	These findings suggest that troglitazone prevents the development of Type 1 diabetes in the MLDSTZ model by suppressing insulitis associated with decreasing TNF alpha production from intraperitoneal exudate cells and the subsequent TNF alpha and IL-1beta-induced beta cell damage.	Troglitazone	28-40	interleukin 1 beta	Mus musculus	246-254
10625061-6	1999	In addition, we demonstrate an in vivo functional interaction between interleukin-1beta converting enyzme-like caspases and free radical production pathways, implicating free radical production as a downstream mediator of the caspase cell death cascade.	Free Radicals	124-136	interleukin 1 beta	Mus musculus	70-87
10625061-6	1999	In addition, we demonstrate an in vivo functional interaction between interleukin-1beta converting enyzme-like caspases and free radical production pathways, implicating free radical production as a downstream mediator of the caspase cell death cascade.	Free Radicals	170-182	interleukin 1 beta	Mus musculus	70-87
9914554-2	1999	We investigated the effects of the cytochrome P450 pathway in IL-1beta-induced calcium release from cultured mouse calvaria in vitro in the presence of clotrimazole, a cytochrome P450 inhibitor, or L-N(G)-arginine methyl ester, a nitric oxide synthase inhibitor.	Clotrimazole	152-164	interleukin 1 beta	Mus musculus	62-70
9814993-6	1998	However, the in vivo inhibition of LPS-induced IL-1beta by UCN was reversed by cyanoketone, indicating that the increase of endogenous glucocorticoids might be more important in IL-1beta inhibition than in TNF inhibition by UCN.	Cyanoketone	79-90	interleukin 1 beta	Mus musculus	47-55
10100728-3	1998	The immunohistochemical analysis of lung tissue sections after silica instillation demonstrated the increased alveolar and interstitial tissue expression of all surface antigens and cytokines studied, mainly Mac-1, F4/80 antigens, TNF-alpha and IL-1beta, which were occasionally observed in normal uninjected and saline-treated mice.	Silicon Dioxide	63-69	interleukin 1 beta	Mus musculus	245-253
10100728-4	1998	These findings show that, after silica instillation, the expression of surface phenotypical markers of lung macrophages increased, and this change was concomitantly associated with an increased expression of the cytokines TNF-alpha and IL-1beta.	Silicon Dioxide	32-38	interleukin 1 beta	Mus musculus	236-244
9878594-17	1998	However, IL-1beta release was significantly increased in CAP/DNFB mice over O/DNFB by 18-fold and by over 30-fold compare to O/O controls.	Dinitrofluorobenzene	61-65	interleukin 1 beta	Mus musculus	9-17
9878594-17	1998	However, IL-1beta release was significantly increased in CAP/DNFB mice over O/DNFB by 18-fold and by over 30-fold compare to O/O controls.	Dinitrofluorobenzene	78-82	interleukin 1 beta	Mus musculus	9-17
9878126-8	1998	Expression of mRNAs for IL-1alpha and IL-1beta was observed in the large intestine of mice which received distilled water containing 3% DSS for 5 days.	Water	116-121	interleukin 1 beta	Mus musculus	38-46
9878126-8	1998	Expression of mRNAs for IL-1alpha and IL-1beta was observed in the large intestine of mice which received distilled water containing 3% DSS for 5 days.	Dextran Sulfate	136-139	interleukin 1 beta	Mus musculus	38-46
9780184-0	1998	Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme).	Nitric Oxide	0-12	interleukin 1 beta	Mus musculus	22-30
9780270-3	1998	In contrast, cortisone-treated animals had, first, an altered clearance of conidia and delayed cytokine production and inflammatory cell recruitment; second, an invasive process in lungs, recruitment of PMNL, and release of IL-6 and IL-1beta; and third, widespread tissue necrosis, sustained release of IL-6 and IL-1beta, further increases in PMNL trafficking but no monocyte recruitment, respiratory failure, and 100% mortality within 5 days.	Cortisone	13-22	interleukin 1 beta	Mus musculus	233-241
9780270-3	1998	In contrast, cortisone-treated animals had, first, an altered clearance of conidia and delayed cytokine production and inflammatory cell recruitment; second, an invasive process in lungs, recruitment of PMNL, and release of IL-6 and IL-1beta; and third, widespread tissue necrosis, sustained release of IL-6 and IL-1beta, further increases in PMNL trafficking but no monocyte recruitment, respiratory failure, and 100% mortality within 5 days.	Cortisone	13-22	interleukin 1 beta	Mus musculus	312-320
9780184-4	1998	Activated RAW264.7 cells released four to five times more IL-1beta, but not TNF-alpha, in the presence of the NO synthase inhibitor N(G)-monomethyl-L-arginine.	omega-N-Methylarginine	132-158	interleukin 1 beta	Mus musculus	58-66
9751175-0	1998	Interleukin-1 beta and tumor necrosis factor-alpha suppress dexamethasone induction of glutamine synthetase in primary mouse astrocytes.	Dexamethasone	60-73	interleukin 1 beta	Mus musculus	0-50
9751175-4	1998	As the glucocorticoid receptor has been shown to interact with transcription factors that may also be activated by the proinflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), we hypothesized that IL-1beta or TNF-alpha might oppose the induction of glutamine synthetase by dexamethasone.	Dexamethasone	316-329	interleukin 1 beta	Mus musculus	145-162
9751175-4	1998	As the glucocorticoid receptor has been shown to interact with transcription factors that may also be activated by the proinflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), we hypothesized that IL-1beta or TNF-alpha might oppose the induction of glutamine synthetase by dexamethasone.	Dexamethasone	316-329	interleukin 1 beta	Mus musculus	164-172
9751175-4	1998	As the glucocorticoid receptor has been shown to interact with transcription factors that may also be activated by the proinflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), we hypothesized that IL-1beta or TNF-alpha might oppose the induction of glutamine synthetase by dexamethasone.	Dexamethasone	316-329	interleukin 1 beta	Mus musculus	240-248
9751175-7	1998	We also found that IL-1beta and TNF-alpha inhibited the induction of glutamine synthetase mRNA by dexamethasone, and that the induction of enzymatic activity was similarly prevented by IL-1beta.	Dexamethasone	98-111	interleukin 1 beta	Mus musculus	19-27
9917862-2	1998	Previous data support the hypothesis that during inflammation, interleukin (IL)-1 beta and IL-6 are involved in fever, in activation of the hypothalamic-pituitary-adrenal (HPA) axis, and in the induction of eicosanoids.	Eicosanoids	207-218	interleukin 1 beta	Mus musculus	63-86
9917862-9	1998	IL-1 beta KO mice showed deficiency in IL-6 following turpentine, but not LPS, injection.	Turpentine	54-64	interleukin 1 beta	Mus musculus	0-9
9917862-3	1998	Most of the pathophysiologic effects of IL-1 beta and Il-6 are mediated by prostaglandins (PGs), modulated by other cytokines, and antagonized by glucocorticoids (GC), a final product of the HPA axis.	Prostaglandins	75-89	interleukin 1 beta	Mus musculus	40-49
9917862-3	1998	Most of the pathophysiologic effects of IL-1 beta and Il-6 are mediated by prostaglandins (PGs), modulated by other cytokines, and antagonized by glucocorticoids (GC), a final product of the HPA axis.	Prostaglandins	91-94	interleukin 1 beta	Mus musculus	40-49
9665390-3	1998	Thioglycollate-elicited peritoneal macrophages cultured in medium alone or in medium supplemented with MDP(Lysyl)GDP (1-100 microg per ml) expressed neither mRNA transcripts for inducible nitric oxide synthase, interleukin-1beta, and tumor necrosis factor-alpha, nor cytokine proteins and nitric oxide activity.	Thioglycolates	0-14	interleukin 1 beta	Mus musculus	211-228
9917863-1	1998	Bacterial lipopolypolysaccharide (LPS)-induced fever involves induction of the proinflammatory cytokines interleukin (IL)-1 alpha, IL-1 beta, tumor necrosis factor-alpha (TNF-alpha), and IL-6, both in the periphery and in the brain.	lipopolypolysaccharide	10-32	interleukin 1 beta	Mus musculus	131-140
9767461-0	1998	Interleukin-1beta partially alleviates cyclosporin A-induced suppression of IgG1 isotype response to thyroglobulin in BALB/c mice in vivo.	Cyclosporine	39-52	interleukin 1 beta	Mus musculus	0-17
9707511-10	1998	However, when VT-fed mice were also challenged with an oral dose of VT equivalent to daily intake at 2 h prior to RNA isolation, vigorous mRNA responses were observed for IL-1beta, IL-6, TNF-alpha, IL-12p40, IL-12p35, IL-2, IFN-gamma, IL-4, and IL-10.	deoxynivalenol	14-16	interleukin 1 beta	Mus musculus	171-179
9697050-0	1998	Roxithromycin down-modulates antigen-presenting and interleukin-1 beta-producing abilities of murine Langerhans cells.	Roxithromycin	0-13	interleukin 1 beta	Mus musculus	52-70
9854510-9	1998	The expression of mRNA of transforming growth factor-beta was suppressed by CY seven days after the injection, and expressions of mRNA of IL-1 beta and TNF-alpha were augmented by the administration of CY 1 to 3 hours after the administration of ONO-4007.	ONO 4007	246-254	interleukin 1 beta	Mus musculus	138-147
9770326-1	1998	Sphingomyelin hydrolysis is induced in myeloid cell-lines by tumour necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta), and interferon gamma (IFN-gamma).	Sphingomyelins	0-13	interleukin 1 beta	Mus musculus	103-121
9770326-1	1998	Sphingomyelin hydrolysis is induced in myeloid cell-lines by tumour necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1beta), and interferon gamma (IFN-gamma).	Sphingomyelins	0-13	interleukin 1 beta	Mus musculus	123-131
9688477-9	1998	The levels of both TNF-alpha and IL-1beta were high in the peritoneum of carrageenan-sensitized mice, suggesting that the increased serum TNF-alpha did not emanate from the peritoneum.	Carrageenan	73-84	interleukin 1 beta	Mus musculus	33-41
9651388-4	1998	269, 15195-15203) reported that potassium depletion of lipopolysaccharide-stimulated mouse macrophages induced by the potassium ionophore, nigericin, leads to the rapid release of mature interleukin-1beta (IL-1beta).	Potassium	32-41	interleukin 1 beta	Mus musculus	187-204
9651388-4	1998	269, 15195-15203) reported that potassium depletion of lipopolysaccharide-stimulated mouse macrophages induced by the potassium ionophore, nigericin, leads to the rapid release of mature interleukin-1beta (IL-1beta).	Potassium	32-41	interleukin 1 beta	Mus musculus	206-214
9651388-4	1998	269, 15195-15203) reported that potassium depletion of lipopolysaccharide-stimulated mouse macrophages induced by the potassium ionophore, nigericin, leads to the rapid release of mature interleukin-1beta (IL-1beta).	Nigericin	139-148	interleukin 1 beta	Mus musculus	187-204
9651388-4	1998	269, 15195-15203) reported that potassium depletion of lipopolysaccharide-stimulated mouse macrophages induced by the potassium ionophore, nigericin, leads to the rapid release of mature interleukin-1beta (IL-1beta).	Nigericin	139-148	interleukin 1 beta	Mus musculus	206-214
9700679-7	1998	These data suggest that central pathways involved in the IL-1 beta-induced activation of the HPA axis and OT cells are, at least in part, dependent upon prostaglandin synthesis.	Prostaglandins	153-166	interleukin 1 beta	Mus musculus	57-66
9700679-0	1998	Indomethacin attenuates oxytocin and hypothalamic-pituitary-adrenal axis responses to systemic interleukin-1 beta.	Indomethacin	0-12	interleukin 1 beta	Mus musculus	95-113
9696057-0	1998	Effects of repeated systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice on interleukin-1beta and nerve growth factor in the striatum.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	47-91	interleukin 1 beta	Mus musculus	110-127
9700679-4	1998	Intra-arterial administration of IL-1 beta (1 pg/kg) to otherwise untreated animals produced a prominent release of ACTH into the plasma, substantial c-fos expression in paraventricular medial parvocellular (mPVN) corticotropin releasing factor (CRF) cells, supraoptic (SON) and paraventricular nucleus (PVN) OT cells, area postrema cells, NTS and VLM catecholamine cells and cells of the central amygdala.	Catecholamines	352-365	interleukin 1 beta	Mus musculus	33-42
9696057-0	1998	Effects of repeated systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice on interleukin-1beta and nerve growth factor in the striatum.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	93-97	interleukin 1 beta	Mus musculus	110-127
9676895-6	1998	In addition to the behavioral variations, IL-1beta dose-dependently increased plasma ACTH and corticosterone concentrations, and also induced several central monoamine alterations.	Corticosterone	94-108	interleukin 1 beta	Mus musculus	42-50
9575306-18	1998	On the basis of these results, together with those reported previously and the known actions of histamine, we propose that an elevation of HDC activity and generation of histamine occur in skeletal muscle following muscle contraction possibly as a result of induction by IL-1beta and that the histamine may be involved in fatigue in skeletal muscle as part of a defence mechanism preventing damage to the muscle.	Histamine	170-179	interleukin 1 beta	Mus musculus	271-279
9575306-18	1998	On the basis of these results, together with those reported previously and the known actions of histamine, we propose that an elevation of HDC activity and generation of histamine occur in skeletal muscle following muscle contraction possibly as a result of induction by IL-1beta and that the histamine may be involved in fatigue in skeletal muscle as part of a defence mechanism preventing damage to the muscle.	Histamine	170-179	interleukin 1 beta	Mus musculus	271-279
9609731-1	1998	Cytomix, a mixture of interferon-gamma, tumor necrosis factor-alpha, and interleukin-1beta, induces nitric oxide (NO) production in lung epithelial cell lines.	Nitric Oxide	100-112	interleukin 1 beta	Mus musculus	73-90
9575306-18	1998	On the basis of these results, together with those reported previously and the known actions of histamine, we propose that an elevation of HDC activity and generation of histamine occur in skeletal muscle following muscle contraction possibly as a result of induction by IL-1beta and that the histamine may be involved in fatigue in skeletal muscle as part of a defence mechanism preventing damage to the muscle.	Histamine	96-105	interleukin 1 beta	Mus musculus	271-279
9676895-6	1998	In addition to the behavioral variations, IL-1beta dose-dependently increased plasma ACTH and corticosterone concentrations, and also induced several central monoamine alterations.	monoamine	158-167	interleukin 1 beta	Mus musculus	42-50
9676895-7	1998	In particular, IL-1beta increased the utilization of norepinephrine (NE) within the paraventricular nucleus, arcuate nucleus/median eminence, locus coeruleus, and prefrontal cortex, while the turnover of dopamine (DA) was evident in the arcuate nucleus/median eminence.	Norepinephrine	53-67	interleukin 1 beta	Mus musculus	15-23
9676895-7	1998	In particular, IL-1beta increased the utilization of norepinephrine (NE) within the paraventricular nucleus, arcuate nucleus/median eminence, locus coeruleus, and prefrontal cortex, while the turnover of dopamine (DA) was evident in the arcuate nucleus/median eminence.	Dopamine	204-212	interleukin 1 beta	Mus musculus	15-23
9676895-7	1998	In particular, IL-1beta increased the utilization of norepinephrine (NE) within the paraventricular nucleus, arcuate nucleus/median eminence, locus coeruleus, and prefrontal cortex, while the turnover of dopamine (DA) was evident in the arcuate nucleus/median eminence.	Dopamine	214-216	interleukin 1 beta	Mus musculus	15-23
9654136-1	1998	Proinflammatory cytokines, a combination of IL-1beta, TNF-alpha, and IFN-gamma, caused mRNA expression of GTP cyclohydrolase I (GTP-CH), the rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, and of inducible nitric oxide synthase (iNOS) in a well-characterized osteoblastic clone MC3T3-E1 cell line.	sapropterin	165-184	interleukin 1 beta	Mus musculus	44-52
9565638-0	1998	Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion.	Turpentine	156-166	interleukin 1 beta	Mus musculus	133-141
9654136-1	1998	Proinflammatory cytokines, a combination of IL-1beta, TNF-alpha, and IFN-gamma, caused mRNA expression of GTP cyclohydrolase I (GTP-CH), the rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, and of inducible nitric oxide synthase (iNOS) in a well-characterized osteoblastic clone MC3T3-E1 cell line.	sapropterin	186-189	interleukin 1 beta	Mus musculus	44-52
9704862-5	1998	administration of LcS has been shown to induce the production of several cytokines, such as IFN-gamma, IL-1beta and TNF-alpha, in the thoracic cavity of mice, resulting in the inhibition of tumour growth and increased survival.	lcs	18-21	interleukin 1 beta	Mus musculus	103-111
9565638-4	1998	Fever development upon injection with turpentine was suppressed in IL-1beta as well as IL-1alpha/beta KO mice, but not in IL-1alpha KO mice, whereas IL-1ra KO mice showed an elevated response.	Turpentine	38-48	interleukin 1 beta	Mus musculus	67-75
9565638-7	1998	In IL-1beta KO mice treated with turpentine, the induction of cyclooxygenase-2 (EC 1.14.99.1) in the diencephalon was suppressed, whereas it was enhanced in IL-1ra KO mice.	Turpentine	33-43	interleukin 1 beta	Mus musculus	3-11
9565638-8	1998	We also found that glucocorticoid induction 8 h after turpentine treatment was suppressed in IL-1beta but not IL-1alpha KO mice.	Turpentine	54-64	interleukin 1 beta	Mus musculus	93-101
9564823-8	1998	injection of 100 ng IL-1beta increased plasma ACTH and corticosterone levels after 1 h (P &lt; 0.02).	Corticosterone	55-69	interleukin 1 beta	Mus musculus	20-28
9629243-6	1998	IL-1 beta and acute stress caused a comparable increase in corticosterone levels in adult mice.	Corticosterone	59-73	interleukin 1 beta	Mus musculus	0-9
9629243-7	1998	In newborn mice, however, IL-1 beta, but not restraint or cold stress, stimulated corticosterone output.	Corticosterone	82-96	interleukin 1 beta	Mus musculus	26-35
9629243-8	1998	Thus, IL-1 beta can elicit a corticosterone response during the postnatal stress-hyporesponsive period.	Corticosterone	29-43	interleukin 1 beta	Mus musculus	6-15
9629243-9	1998	Furthermore, when the corticosterone levels attained following IL-1 beta administration were compared to the basal levels of the hormone at a given age, the increase in plasma corticosterone levels was several fold higher in newborn than in adult animals.	Corticosterone	22-36	interleukin 1 beta	Mus musculus	63-72
9629243-9	1998	Furthermore, when the corticosterone levels attained following IL-1 beta administration were compared to the basal levels of the hormone at a given age, the increase in plasma corticosterone levels was several fold higher in newborn than in adult animals.	Corticosterone	176-190	interleukin 1 beta	Mus musculus	63-72
9629244-3	1998	Here we report that the administration to mice of a low dose of IL-1 beta during the first days of life results in a decreased dopamine content in the hypothalamus in adulthood.	Dopamine	127-135	interleukin 1 beta	Mus musculus	64-73
9629244-4	1998	We also show that the dopamine content of the superior cervical sympathetic ganglia was reduced in adult mice that were treated with IL-1 beta at birth.	Dopamine	22-30	interleukin 1 beta	Mus musculus	133-142
9629247-2	1998	The effect of interleukin-1 beta (IL-1 beta) on glucose blood levels serves as an example.	Glucose	48-55	interleukin 1 beta	Mus musculus	14-32
9629247-2	1998	The effect of interleukin-1 beta (IL-1 beta) on glucose blood levels serves as an example.	Glucose	48-55	interleukin 1 beta	Mus musculus	34-43
9629247-3	1998	Although IL-1 beta stimulates glucocorticoid output and decreases hepatic glycogen content, hypoglycemia is concomitantly detected in adult and newborn mice.	Glycogen	74-82	interleukin 1 beta	Mus musculus	9-18
9659467-5	1998	RESULTS: Interleukin-1 beta (IL-1 beta) induced nitrite production by VSMCs in a time-dependent manner.	Nitrites	48-55	interleukin 1 beta	Mus musculus	9-27
9662416-0	1998	Modulation of IL-1beta, IL-6 and TNF-alpha secretion and mRNA expression by the trichothecene vomitoxin in the RAW 264.7 murine macrophage cell line.	Trichothecenes	80-93	interleukin 1 beta	Mus musculus	14-22
9662416-0	1998	Modulation of IL-1beta, IL-6 and TNF-alpha secretion and mRNA expression by the trichothecene vomitoxin in the RAW 264.7 murine macrophage cell line.	deoxynivalenol	94-103	interleukin 1 beta	Mus musculus	14-22
9580629-3	1998	Inhibition of PC-PLC by the specific inhibitor tricyclodecan-9-yl-xanthogenate (D609) before LPS reduced the release of interleukin-1 beta, interleukin-6 and nitric oxide (NO) in vivo.	tricyclodecan-9-yl-xanthogenate	47-78	interleukin 1 beta	Mus musculus	120-138
9580629-3	1998	Inhibition of PC-PLC by the specific inhibitor tricyclodecan-9-yl-xanthogenate (D609) before LPS reduced the release of interleukin-1 beta, interleukin-6 and nitric oxide (NO) in vivo.	tricyclodecane-9-yl-xanthogenate	80-84	interleukin 1 beta	Mus musculus	120-138
9579511-9	1998	Interleukin-1beta was upregulated even with saline instillation but could not be detected in the supernatant of the cell culture.	Sodium Chloride	44-50	interleukin 1 beta	Mus musculus	0-17
9529499-9	1998	Both continuous metronidazole and aztreonam reduced lung MPO concentration (P &lt; 0.05) and TNF-alpha and IL-1 beta mRNA expression (P &lt; 0.05) compared with those in saline controls.	Metronidazole	16-29	interleukin 1 beta	Mus musculus	107-116
9529499-9	1998	Both continuous metronidazole and aztreonam reduced lung MPO concentration (P &lt; 0.05) and TNF-alpha and IL-1 beta mRNA expression (P &lt; 0.05) compared with those in saline controls.	Aztreonam	34-43	interleukin 1 beta	Mus musculus	107-116
9659467-5	1998	RESULTS: Interleukin-1 beta (IL-1 beta) induced nitrite production by VSMCs in a time-dependent manner.	Nitrites	48-55	interleukin 1 beta	Mus musculus	29-38
9659467-5	1998	RESULTS: Interleukin-1 beta (IL-1 beta) induced nitrite production by VSMCs in a time-dependent manner.	vsmcs	70-75	interleukin 1 beta	Mus musculus	9-27
9659467-5	1998	RESULTS: Interleukin-1 beta (IL-1 beta) induced nitrite production by VSMCs in a time-dependent manner.	vsmcs	70-75	interleukin 1 beta	Mus musculus	29-38
9659467-6	1998	The addition of the mouse monocyte cell line J774 to IL-1 beta-stimulated VSMCs further increased nitrite production in a monocyte number-dependent manner.	Nitrites	98-105	interleukin 1 beta	Mus musculus	53-62
9659467-8	1998	Addition of tumor necrosis factor-alpha (TNF-alpha) also enhanced IL-1 beta-induced nitrite production by VSMCs, but TNF-alpha showed no effect in the presence of monocytes.	Nitrites	84-91	interleukin 1 beta	Mus musculus	66-75
9659467-8	1998	Addition of tumor necrosis factor-alpha (TNF-alpha) also enhanced IL-1 beta-induced nitrite production by VSMCs, but TNF-alpha showed no effect in the presence of monocytes.	vsmcs	106-111	interleukin 1 beta	Mus musculus	66-75
9659467-9	1998	Coculture of monocytes and VSMCs in the presence of IL-1 beta secreted substantial amounts of TNF-alpha.	vsmcs	27-32	interleukin 1 beta	Mus musculus	52-61
9462694-6	1998	The addition of either 100 microg/ml mannan or paraformaldehyde (PFA)-fixed 1-DMM-treated B16M cells to cultured HSE for a period of 12 h significantly (P &lt; 0.01) increased the release of IL-1beta from the HSE compared to that liberated by the HSE incubated with either basal medium or PFA-fixed untreated B16M cells.	paraform	47-63	interleukin 1 beta	Mus musculus	191-199
9510087-10	1998	Quinacrine, and to a lesser extent chloroquine, has an inhibitory effect on the lipopolysaccharide- or zymosan-induced expression of interleukin 1beta and tumor necrosis factor alpha, both at the mRNA and protein levels.	Quinacrine	0-10	interleukin 1 beta	Mus musculus	133-182
9510087-10	1998	Quinacrine, and to a lesser extent chloroquine, has an inhibitory effect on the lipopolysaccharide- or zymosan-induced expression of interleukin 1beta and tumor necrosis factor alpha, both at the mRNA and protein levels.	Chloroquine	35-46	interleukin 1 beta	Mus musculus	133-182
9510087-10	1998	Quinacrine, and to a lesser extent chloroquine, has an inhibitory effect on the lipopolysaccharide- or zymosan-induced expression of interleukin 1beta and tumor necrosis factor alpha, both at the mRNA and protein levels.	Zymosan	103-110	interleukin 1 beta	Mus musculus	133-182
9613682-6	1998	The peritoneal lavage fluid (PLF) of SCF- mice also showed a marked increase in IL-1beta following zymosan administration, whereas local IL-6 and TNF-alpha production were not affected.	Zymosan	99-106	interleukin 1 beta	Mus musculus	80-88
9500698-9	1998	Gadolinium chloride and liposome-encapsulated dichloromethylene diphosphonate lowered LPS-mediated HO-1 mRNA accumulation (by about 50%); in these groups hepatic levels of interleukin (IL)-1beta were decreased, by more than 75%.	gadolinium chloride	0-19	interleukin 1 beta	Mus musculus	172-194
9500698-9	1998	Gadolinium chloride and liposome-encapsulated dichloromethylene diphosphonate lowered LPS-mediated HO-1 mRNA accumulation (by about 50%); in these groups hepatic levels of interleukin (IL)-1beta were decreased, by more than 75%.	Clodronic Acid	46-77	interleukin 1 beta	Mus musculus	172-194
9462694-6	1998	The addition of either 100 microg/ml mannan or paraformaldehyde (PFA)-fixed 1-DMM-treated B16M cells to cultured HSE for a period of 12 h significantly (P &lt; 0.01) increased the release of IL-1beta from the HSE compared to that liberated by the HSE incubated with either basal medium or PFA-fixed untreated B16M cells.	paraform	65-68	interleukin 1 beta	Mus musculus	191-199
9462694-6	1998	The addition of either 100 microg/ml mannan or paraformaldehyde (PFA)-fixed 1-DMM-treated B16M cells to cultured HSE for a period of 12 h significantly (P &lt; 0.01) increased the release of IL-1beta from the HSE compared to that liberated by the HSE incubated with either basal medium or PFA-fixed untreated B16M cells.	dimethylmyleran	78-81	interleukin 1 beta	Mus musculus	191-199
9462694-6	1998	The addition of either 100 microg/ml mannan or paraformaldehyde (PFA)-fixed 1-DMM-treated B16M cells to cultured HSE for a period of 12 h significantly (P &lt; 0.01) increased the release of IL-1beta from the HSE compared to that liberated by the HSE incubated with either basal medium or PFA-fixed untreated B16M cells.	paraform	289-292	interleukin 1 beta	Mus musculus	191-199
9570551-7	1998	The specific p38 inhibitor SB203580 abrogated the mycoplasma-induced IL-6, IL-1beta, and TNF-alpha synthesis.	SB 203580	27-35	interleukin 1 beta	Mus musculus	75-83
9498792-5	1998	Proteolysis of pro-IL-1 beta initiates within 7.5 min of ATP addition; 17-kDa mature IL-1 beta is observed first intracellularly and subsequently extracellularly.	Adenosine Triphosphate	57-60	interleukin 1 beta	Mus musculus	19-28
9498792-7	1998	Macrophages exposed to ATP continuously or only for a 15-min pulse release IL-1 alpha, IL-1 beta, and lactate dehydrogenase (LDH).	Adenosine Triphosphate	23-26	interleukin 1 beta	Mus musculus	87-96
9498792-9	1998	Ethacrynic acid and DIDS (4,4"-diisothiocyanato-stilbene-2,2"-disulfonic acid) block ATP-induced proteolysis of pro-IL-1 beta and prevent release of pro-IL-1 alpha/beta and LDH; they do not inhibit ATP-induced K+ (86Rb+) efflux.	Ethacrynic Acid	0-15	interleukin 1 beta	Mus musculus	116-125
9498792-9	1998	Ethacrynic acid and DIDS (4,4"-diisothiocyanato-stilbene-2,2"-disulfonic acid) block ATP-induced proteolysis of pro-IL-1 beta and prevent release of pro-IL-1 alpha/beta and LDH; they do not inhibit ATP-induced K+ (86Rb+) efflux.	dids (4,4"-diisothiocyanato-stilbene-2,2"-disulfonic acid	20-77	interleukin 1 beta	Mus musculus	116-125
9498792-9	1998	Ethacrynic acid and DIDS (4,4"-diisothiocyanato-stilbene-2,2"-disulfonic acid) block ATP-induced proteolysis of pro-IL-1 beta and prevent release of pro-IL-1 alpha/beta and LDH; they do not inhibit ATP-induced K+ (86Rb+) efflux.	Adenosine Triphosphate	85-88	interleukin 1 beta	Mus musculus	116-125
9498792-12	1998	These results indicate that ATP stimulates externalization of both IL-1 alpha and IL-1 beta.	Adenosine Triphosphate	28-31	interleukin 1 beta	Mus musculus	82-91
9446682-2	1998	To investigate the possibility of enhancing the immunogenicity of recombinant antigens delivered by live-attenuated Salmonella strains, we inserted an oligonucleotide coding for the nonapeptide from murine IL-1beta into the genes of three model proteins: LamB, MalE, and flagellin.	Oligonucleotides	151-166	interleukin 1 beta	Mus musculus	206-214
9493504-4	1998	Interleukin (IL)-1beta appears to be critically involved in fever caused by some routes of infection/inflammation (e.g. localized inflammation with turpentine).	Turpentine	148-158	interleukin 1 beta	Mus musculus	0-22
9666341-7	1998	IL-1 beta completely inhibited cAMP-stimulated testosterone production and P450c17 mRNA expression.	Cyclic AMP	31-35	interleukin 1 beta	Mus musculus	0-9
9666341-7	1998	IL-1 beta completely inhibited cAMP-stimulated testosterone production and P450c17 mRNA expression.	Testosterone	47-59	interleukin 1 beta	Mus musculus	0-9
9498792-0	1998	Post-translational processing of murine IL-1: evidence that ATP-induced release of IL-1 alpha and IL-1 beta occurs via a similar mechanism.	Adenosine Triphosphate	60-63	interleukin 1 beta	Mus musculus	98-107
9498792-2	1998	Externalization and proteolytic processing of pro-IL-1 beta can be initiated by extracellular ATP.	Adenosine Triphosphate	94-97	interleukin 1 beta	Mus musculus	50-59
9570551-8	1998	The selective MAPK/extracellular signal-regulated kinase 1 (MEK-1) inhibitor PD-98059 blocked both IL-1beta and TNF-alpha but not IL-6 production by RAW 264.7 cells in response to LAMPf.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	77-85	interleukin 1 beta	Mus musculus	99-107
9551941-6	1998	IL-1beta was detected only in a neutrophil-rich fraction of the IPNMC, but not in T and B lymphocytes positively selected from the IPNMC.	ipnmc	64-69	interleukin 1 beta	Mus musculus	0-8
9551941-7	1998	Cyclophosphamide (CTX)-treated neutropenic mice expressed significantly less IL-1beta in IPNMC after hemorrhage or endotoxemia compared with CTX-untreated controls.	Cyclophosphamide	0-16	interleukin 1 beta	Mus musculus	77-85
9551941-7	1998	Cyclophosphamide (CTX)-treated neutropenic mice expressed significantly less IL-1beta in IPNMC after hemorrhage or endotoxemia compared with CTX-untreated controls.	ipnmc	89-94	interleukin 1 beta	Mus musculus	77-85
9782309-10	1998	Ribavirin, a synthetic guanosine analogue prolonged survival to MHV-3 infection, inhibited production and transcription of the macrophage pro-inflammatory cytokines IL-1 beta and TNF-alpha and Th2 cytokines while preserving Th1 cytokine production.	Ribavirin	0-9	interleukin 1 beta	Mus musculus	165-174
9666273-8	1998	It was found that THC suppressed IL-12, IL-15 and IL-6 and increased IL-1 alpha, IL-1 beta, and TNF alpha in all of the stimulated cultures.	Dronabinol	18-21	interleukin 1 beta	Mus musculus	81-90
9634927-5	1998	For example, 24 h treatment of acinar cells with IL-6 or IFN-gamma did not alter basal or carbachol-stimulated protein (beta-hexosaminidase) secretion, whereas a combination of IL-1 alpha and IL-1 beta decreased carbachol-stimulated beta-hexosaminidase secretion by 80%.	Carbachol	212-221	interleukin 1 beta	Mus musculus	192-201
9528718-10	1998	Injection of IL-6, TNFalpha and IL-1beta in mice markedly decreased the phosphate serum levels.	Phosphates	72-81	interleukin 1 beta	Mus musculus	32-40
9458919-6	1998	In IL-1 beta +/+ mice, both LPS and turpentine increased leptin mRNA and circulating leptin.	Turpentine	36-46	interleukin 1 beta	Mus musculus	3-12
9458919-9	1998	We conclude that IL-1 beta is essential for leptin induction by both LPS and turpentine in mice, but IL-6 is not.	Turpentine	77-87	interleukin 1 beta	Mus musculus	17-26
9458784-6	1998	By ELISA, stimulated MPACs showed a significant increase in IL-1 beta (P &lt; 0.03) and IL-6 (P &lt; 0.01) release into supernatants by 10 min that paralleled the time course of amylase release.	mpacs	21-26	interleukin 1 beta	Mus musculus	60-69
9458784-9	1998	This study shows that MPACs synthesize IL-1 beta and IL-6 and release these cytokines from their granules after alpha- and beta-adrenergic stimulation.	mpacs	22-27	interleukin 1 beta	Mus musculus	39-48
10474025-6	1998	Finally, proliferation of B16F10 cells in the presence of several doses of CsA did not vary and CsA increased the amount of IL-1beta mRNA expression.	Cyclosporine	96-99	interleukin 1 beta	Mus musculus	124-132
9430501-6	1998	Furthermore, L-NAME inhibited the cutaneous reactions caused by both interleukin-1beta and tumor necrosis factor-alpha, putative mediators of the late-phase edema in the biphasic cutaneous reaction.	NG-Nitroarginine Methyl Ester	13-19	interleukin 1 beta	Mus musculus	69-118
9546746-6	1998	Persistent overexpression of both IL-1beta and TNFalpha were found at 2 and 16 weeks in the lungs of silica-exposed mice compared with air-sham control mice.	Silicon Dioxide	101-107	interleukin 1 beta	Mus musculus	34-42
9427519-12	1997	That dexamethasone inhibited the expression of ICE, suggests that corticosteroids regulate the secretion of IL-1beta by microglial cells, in part, by regulating the expression of ICE.	Dexamethasone	5-18	interleukin 1 beta	Mus musculus	108-116
9657065-2	1997	We have shown previously that both tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1-beta) inhibit 8-bromo-cAMP-(8-Br-cAMP)-stimulated steroidogenesis in mouse Leydig cells.	8-Bromo Cyclic Adenosine Monophosphate	118-130	interleukin 1 beta	Mus musculus	79-97
9657065-2	1997	We have shown previously that both tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1-beta) inhibit 8-bromo-cAMP-(8-Br-cAMP)-stimulated steroidogenesis in mouse Leydig cells.	8-Bromo Cyclic Adenosine Monophosphate	118-130	interleukin 1 beta	Mus musculus	99-108
9657065-2	1997	We have shown previously that both tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1-beta) inhibit 8-bromo-cAMP-(8-Br-cAMP)-stimulated steroidogenesis in mouse Leydig cells.	8-br	132-136	interleukin 1 beta	Mus musculus	79-97
9657065-2	1997	We have shown previously that both tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1-beta) inhibit 8-bromo-cAMP-(8-Br-cAMP)-stimulated steroidogenesis in mouse Leydig cells.	8-br	132-136	interleukin 1 beta	Mus musculus	99-108
9657065-2	1997	We have shown previously that both tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1-beta) inhibit 8-bromo-cAMP-(8-Br-cAMP)-stimulated steroidogenesis in mouse Leydig cells.	Cyclic AMP	126-130	interleukin 1 beta	Mus musculus	79-97
9657065-2	1997	We have shown previously that both tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1-beta) inhibit 8-bromo-cAMP-(8-Br-cAMP)-stimulated steroidogenesis in mouse Leydig cells.	Cyclic AMP	126-130	interleukin 1 beta	Mus musculus	99-108
9421737-5	1997	Treatment of mice with rolipram completely suppressed both TNF-alpha and IL-1 beta production in intestinal tracts, induced by H. nana challenge infection.	Rolipram	23-31	interleukin 1 beta	Mus musculus	73-82
9352880-1	1997	BACKGROUND &amp; AIMS: During severe pancreatitis, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha are produced in large quantities.	Adenosine Monophosphate	12-15	interleukin 1 beta	Mus musculus	51-73
9486113-5	1997	It was found that like anti-TNF-alpha, anti-IL-1 beta administered systemically to mice (by intraperitoneal injection), prior to skin sensitization with the contact allergen oxazolone, resulted in a marked inhibition of DC accumulation in draining lymph nodes.	Oxazolone	174-183	interleukin 1 beta	Mus musculus	44-53
9361908-4	1997	administration of 50 mg/kg of oligonucleotide, significant increases in the splenic mRNA levels of IL-6, IL-12p40, IL-1 beta, and IL-1Ra and serum levels of IL-6, IL-12, MIP-1 beta, and MCP-1 were observed.	Oligonucleotides	30-45	interleukin 1 beta	Mus musculus	115-124
9298129-5	1997	Levels of intracellular interleukin-1 beta, as determined by flowcytometry, were also increased 1 h after acetone treatment or tape stripping.	Acetone	106-113	interleukin 1 beta	Mus musculus	24-42
9338609-6	1997	The levels of interleukin (IL-)6 were elevated and those of IL-1beta were decreased in mice consuming Quil-A-supplemented diets.	Quil A	102-108	interleukin 1 beta	Mus musculus	60-68
9339387-12	1997	Benzydamine, therapeutically administered at 20 mg/kg s.c., significantly reduced TNF alpha and IL-1 beta production induced by LPS both in serum and lungs and it was shown to inhibit TNF-dependent cytoxicity on L929 cells.	Benzydamine	0-11	interleukin 1 beta	Mus musculus	96-105
9284114-5	1997	In an additional experiment, we observed that chloramphenicol clearly inhibited P-LPS-stimulated expression of the CD14, IL-1beta, and IL-6 genes in calvarial cells.	Chloramphenicol	46-61	interleukin 1 beta	Mus musculus	121-129
9242654-5	1997	Exogenous addition or enforced expression of type IIA sPLA2 significantly increased IL-1beta/TNFalpha-initiated PGE2 generation, which was accompanied by increased expression of both cPLA2 and COX-2 and suppressed by inhibitors of these enzymes.	Dinoprostone	112-116	interleukin 1 beta	Mus musculus	84-92
9278346-10	1997	To test this hypothesis, IL-1beta-activated myoblasts were loaded with 6-carboxy-2",7"-dichlorodihydrofluorescein diacetate, di(acetoxymethylester) (DCFH), a marker for oxidative stress.	DCFH	149-153	interleukin 1 beta	Mus musculus	25-33
9242654-3	1997	Kinetic and pharmacological studies showed that delayed PGE2 generation by this cell line in response to interleukin (IL)-1beta and tumor necrosis factor alpha (TNFalpha) was dependent upon cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX)-2.	Dinoprostone	56-60	interleukin 1 beta	Mus musculus	105-127
9378493-2	1997	Chlorpromazine and dexamethasone protect mice against lethal endotoxaemia by decreasing circulating concentrations of TNF-alpha and IL-1 beta.	Chlorpromazine	0-14	interleukin 1 beta	Mus musculus	132-141
9378493-2	1997	Chlorpromazine and dexamethasone protect mice against lethal endotoxaemia by decreasing circulating concentrations of TNF-alpha and IL-1 beta.	Dexamethasone	19-32	interleukin 1 beta	Mus musculus	132-141
9378493-9	1997	In conclusion, chlorpromazine inhibits TNF-alpha and IL-1 beta production in mice at concentrations that cannot be reached in humans, thus precluding its usage in clinical anti-cytokine strategies.	Chlorpromazine	15-29	interleukin 1 beta	Mus musculus	53-62
9249578-1	1997	Interleukin (IL)-1 beta-deficient (IL-1 beta -/-) mice exhibited decreased zymosan-induced lethality and reduced production of IL-6 compared with wild-type controls (IL-1 beta +/+).	Zymosan	75-82	interleukin 1 beta	Mus musculus	35-44
9249578-2	1997	In addition, IL-1 beta -/- mice had a diminished cellular infiltrate (33%) in the peritoneal cavity after zymosan.	Zymosan	106-113	interleukin 1 beta	Mus musculus	13-22
9249578-4	1997	The induction of corticosterone was only slightly reduced (14%) in IL-1 beta -/- mice.	Corticosterone	17-31	interleukin 1 beta	Mus musculus	67-76
9249578-9	1997	Our results demonstrate that IL-1 beta plays a significant, although not exclusive, role in the physiological and cytokine responses to zymosan-mediated inflammation.	Zymosan	136-143	interleukin 1 beta	Mus musculus	29-38
9166662-0	1997	Treatment with neutralizing antibodies specific for IL-1beta prevents cyclophosphamide-induced diabetes in nonobese diabetic mice.	Cyclophosphamide	70-86	interleukin 1 beta	Mus musculus	52-60
9222544-19	1997	The above data support the notion that induction of lipocortin by dexamethasone plays a major role in the inhibition by dexamethasone of inflammatory hyperalgesia evoked by carrageenin, bradykinin and the cytokines TNF alpha, IL-1 beta and IL-6, and provides additional evidence that the biological activity of lipocortin resides within the peptide lipocortin-1(2-26).	Dexamethasone	66-79	interleukin 1 beta	Mus musculus	226-235
9222544-19	1997	The above data support the notion that induction of lipocortin by dexamethasone plays a major role in the inhibition by dexamethasone of inflammatory hyperalgesia evoked by carrageenin, bradykinin and the cytokines TNF alpha, IL-1 beta and IL-6, and provides additional evidence that the biological activity of lipocortin resides within the peptide lipocortin-1(2-26).	Dexamethasone	120-133	interleukin 1 beta	Mus musculus	226-235
9245558-2	1997	In vitro studies suggest that M phi Ao can be induced by IL-1 beta via interleukin-1 beta-converting enzyme (ICE, a cysteine protease), prostanoids, or reactive oxygen/nitrogen.	Prostaglandins	136-147	interleukin 1 beta	Mus musculus	57-66
9245558-2	1997	In vitro studies suggest that M phi Ao can be induced by IL-1 beta via interleukin-1 beta-converting enzyme (ICE, a cysteine protease), prostanoids, or reactive oxygen/nitrogen.	reactive oxygen/nitrogen	152-176	interleukin 1 beta	Mus musculus	57-66
9195135-0	1997	S-methyl-L-thiocitrulline counteracts interleukin 1 beta induced suppression of pancreatic islet function in vitro, but does not protect against multiple low-dose streptozotocin-induced diabetes in vivo.	S-methylthiocitrulline	0-25	interleukin 1 beta	Mus musculus	38-56
9217070-5	1997	Astrocytes comprising the new GL were positive for anti-IL-1beta.	gl	30-32	interleukin 1 beta	Mus musculus	56-64
9217070-9	1997	These data suggest that upregulation of IL-1beta in astrocytes and interaction of IL-1beta with the neural IL-1 receptor are important for reconstruction of the GL following prenatal lesion in the murine brain.	gl	161-163	interleukin 1 beta	Mus musculus	40-48
9217070-9	1997	These data suggest that upregulation of IL-1beta in astrocytes and interaction of IL-1beta with the neural IL-1 receptor are important for reconstruction of the GL following prenatal lesion in the murine brain.	gl	161-163	interleukin 1 beta	Mus musculus	82-90
9467754-8	1997	IL-1 beta alone significantly stimulated the antibody production and adding NaBu to this IL-1 beta-supplemented culture caused a further increase.	sethoxydim	76-80	interleukin 1 beta	Mus musculus	89-98
9195135-4	1997	S-methyl-L-thiocitrulline alone did not affect the islet glucose oxidation rate, but all concentrations of S-methyl-L-thiocitrulline prevented IL-1 beta induced suppression of the islet glucose metabolism.	S-methylthiocitrulline	107-132	interleukin 1 beta	Mus musculus	143-152
9195135-4	1997	S-methyl-L-thiocitrulline alone did not affect the islet glucose oxidation rate, but all concentrations of S-methyl-L-thiocitrulline prevented IL-1 beta induced suppression of the islet glucose metabolism.	Glucose	186-193	interleukin 1 beta	Mus musculus	143-152
9127007-5	1997	However, at high concentrations of LPS or Taxol, a CD14-independent pathway of activation is observed: this pathway leads to minimal IP-10 gene induction, even though induction of TNF-alpha and IL-1beta occurs.	Paclitaxel	42-47	interleukin 1 beta	Mus musculus	194-202
9195135-6	1997	IL-1 beta caused a more than 10-fold increase in medium nitrite production, an indication of nitric oxide production, which was blocked by S-methyl-L-thiocitrulline.	Nitrites	56-63	interleukin 1 beta	Mus musculus	0-9
9195135-6	1997	IL-1 beta caused a more than 10-fold increase in medium nitrite production, an indication of nitric oxide production, which was blocked by S-methyl-L-thiocitrulline.	Nitric Oxide	93-105	interleukin 1 beta	Mus musculus	0-9
9195135-6	1997	IL-1 beta caused a more than 10-fold increase in medium nitrite production, an indication of nitric oxide production, which was blocked by S-methyl-L-thiocitrulline.	S-methylthiocitrulline	139-164	interleukin 1 beta	Mus musculus	0-9
9195135-8	1997	The efficacy of S-methyl-L-thiocitrulline, NG-monomethyl-L-arginine and aminoguanidine in counteracting IL-1 beta induced nitrite formation was also compared.	S-methylthiocitrulline	16-41	interleukin 1 beta	Mus musculus	104-113
9195135-8	1997	The efficacy of S-methyl-L-thiocitrulline, NG-monomethyl-L-arginine and aminoguanidine in counteracting IL-1 beta induced nitrite formation was also compared.	pimagedine	72-86	interleukin 1 beta	Mus musculus	104-113
9195135-8	1997	The efficacy of S-methyl-L-thiocitrulline, NG-monomethyl-L-arginine and aminoguanidine in counteracting IL-1 beta induced nitrite formation was also compared.	Nitrites	122-129	interleukin 1 beta	Mus musculus	104-113
9127007-7	1997	These data suggest the existence of two pathways of activation by both LPS and Taxol: one that is CD14 dependent and leads to induction of TNF-alpha, IL-1beta, and IP-10 gene induction, and a CD14-independent pathway that results in the induction of TNF-alpha and IL-1beta, with minimal induction of IP-10.	Paclitaxel	79-84	interleukin 1 beta	Mus musculus	150-158
9127007-7	1997	These data suggest the existence of two pathways of activation by both LPS and Taxol: one that is CD14 dependent and leads to induction of TNF-alpha, IL-1beta, and IP-10 gene induction, and a CD14-independent pathway that results in the induction of TNF-alpha and IL-1beta, with minimal induction of IP-10.	Paclitaxel	79-84	interleukin 1 beta	Mus musculus	264-272
9119995-4	1997	Treatment of mice with the alpha-adrenergic receptor antagonist phentolamine prevented not only the elevation in mRNA levels of IL-1beta, TNF-alpha, and TGF-beta1, the increase in IL-1beta protein, but also the activation of nuclear factor (NF)-KB and cyclic AMP response element binding protein, which occurred in lung cells of untreated animals during the first hour after hemorrhage.	Phentolamine	64-76	interleukin 1 beta	Mus musculus	128-136
9096130-3	1997	We report here that treating striatal astrocytes in primary culture with IL-1beta for 22-24 hr enhances the ATP-evoked release of arachidonic acid (AA) with no effect on the ATP-induced accumulation of inositol phosphates.	Adenosine Triphosphate	108-111	interleukin 1 beta	Mus musculus	73-81
9096130-3	1997	We report here that treating striatal astrocytes in primary culture with IL-1beta for 22-24 hr enhances the ATP-evoked release of arachidonic acid (AA) with no effect on the ATP-induced accumulation of inositol phosphates.	Arachidonic Acid	130-146	interleukin 1 beta	Mus musculus	73-81
9096130-5	1997	Indeed, P2Y2 antisense oligonucleotides reduce the ATP-evoked release of AA only from IL-1beta-treated astrocytes.	Oligonucleotides	23-39	interleukin 1 beta	Mus musculus	86-94
9096130-5	1997	Indeed, P2Y2 antisense oligonucleotides reduce the ATP-evoked release of AA only from IL-1beta-treated astrocytes.	Adenosine Triphosphate	51-54	interleukin 1 beta	Mus musculus	86-94
10851453-11	1997	Bone marrow granulocyte-macrophage colony forming units (CFU-GM) from mice treated with IL-1 beta demonstrated increased ex-vivo resistance to cisplatin, without altering its sensitivity to high specific activity 3H-thymidine (a measure of cell fraction in S-phase).	Cisplatin	143-152	interleukin 1 beta	Mus musculus	88-97
9159493-3	1997	After inducing the endogenous NO production with interleukin 1beta (IL-1beta) and interferon-gamma (IFN-gamma) the superoxide anion release was significantly reduced, which was reversed by the inhibition of the NO synthase.	Superoxides	115-131	interleukin 1 beta	Mus musculus	49-66
9159493-3	1997	After inducing the endogenous NO production with interleukin 1beta (IL-1beta) and interferon-gamma (IFN-gamma) the superoxide anion release was significantly reduced, which was reversed by the inhibition of the NO synthase.	Superoxides	115-131	interleukin 1 beta	Mus musculus	68-76
9119995-5	1997	In contrast, treatment before hemorrhage with the beta-adrenergic receptor antagonist propranolol was associated with increases in mRNA levels for IL-1beta, TNF-alpha, and TGF-beta1, which were greater than those present in untreated hemorrhaged mice, and did not prevent hemorrhage-associated increases in lung IL-1beta protein.	Propranolol	86-97	interleukin 1 beta	Mus musculus	147-155
9119995-5	1997	In contrast, treatment before hemorrhage with the beta-adrenergic receptor antagonist propranolol was associated with increases in mRNA levels for IL-1beta, TNF-alpha, and TGF-beta1, which were greater than those present in untreated hemorrhaged mice, and did not prevent hemorrhage-associated increases in lung IL-1beta protein.	Propranolol	86-97	interleukin 1 beta	Mus musculus	312-320
9119995-4	1997	Treatment of mice with the alpha-adrenergic receptor antagonist phentolamine prevented not only the elevation in mRNA levels of IL-1beta, TNF-alpha, and TGF-beta1, the increase in IL-1beta protein, but also the activation of nuclear factor (NF)-KB and cyclic AMP response element binding protein, which occurred in lung cells of untreated animals during the first hour after hemorrhage.	Phentolamine	64-76	interleukin 1 beta	Mus musculus	180-188
9812850-0	1997	[Protective effect of interleukin-1 beta on acetaminophen induced liver damage in mice].	Acetaminophen	44-57	interleukin 1 beta	Mus musculus	22-40
9106264-6	1997	The addition of 8-bromo-cyclic AMP, but not 8-bromo-cyclic GMP, was found to further enhance the expression of iNOS activity induced by IL-1 beta and IFN-gamma co-stimulation.	8-Bromo Cyclic Adenosine Monophosphate	16-34	interleukin 1 beta	Mus musculus	136-145
9812850-1	1997	In the model of liver damage induced by acetaminophen of mice, injection of interleukin-1 beta (IL-1 beta, i.p.	Acetaminophen	40-53	interleukin 1 beta	Mus musculus	76-94
9812850-4	1997	Treatment with IL-1 beta of different doses (10,000, 30,000 or 50,000 U/kg) 12 h before the administration of acetaminophen could reduce the leakages of transaminases in a dose dependent manner and decrease the mortality of mice.	Acetaminophen	110-123	interleukin 1 beta	Mus musculus	15-24
9812850-6	1997	Further experiments showed that IL-1 beta could increase the content of reduced glutathione (GSH) in normal liver and reverse the decline of GSH and the increase of GSSG induced by acetaminophen.	Glutathione	80-91	interleukin 1 beta	Mus musculus	32-41
9812850-6	1997	Further experiments showed that IL-1 beta could increase the content of reduced glutathione (GSH) in normal liver and reverse the decline of GSH and the increase of GSSG induced by acetaminophen.	Glutathione	93-96	interleukin 1 beta	Mus musculus	32-41
9812850-6	1997	Further experiments showed that IL-1 beta could increase the content of reduced glutathione (GSH) in normal liver and reverse the decline of GSH and the increase of GSSG induced by acetaminophen.	Glutathione	141-144	interleukin 1 beta	Mus musculus	32-41
9812850-6	1997	Further experiments showed that IL-1 beta could increase the content of reduced glutathione (GSH) in normal liver and reverse the decline of GSH and the increase of GSSG induced by acetaminophen.	Glutathione Disulfide	165-169	interleukin 1 beta	Mus musculus	32-41
9812850-6	1997	Further experiments showed that IL-1 beta could increase the content of reduced glutathione (GSH) in normal liver and reverse the decline of GSH and the increase of GSSG induced by acetaminophen.	Acetaminophen	181-194	interleukin 1 beta	Mus musculus	32-41
9812850-7	1997	IL-1 beta could also reduce malondiadehyde (MDA) content enhanced by acetaminophen.	malondiadehyde	28-42	interleukin 1 beta	Mus musculus	0-9
9812850-7	1997	IL-1 beta could also reduce malondiadehyde (MDA) content enhanced by acetaminophen.	Acetaminophen	69-82	interleukin 1 beta	Mus musculus	0-9
9812850-8	1997	The above results indicate that the preventive effect of IL-1 beta against liver damage due to acetaminophen may be mediated through IL-1 beta receptor by increasing glutathione synthesis and decreasing lipid peroxidation of the liver.	Acetaminophen	95-108	interleukin 1 beta	Mus musculus	57-66
9812850-8	1997	The above results indicate that the preventive effect of IL-1 beta against liver damage due to acetaminophen may be mediated through IL-1 beta receptor by increasing glutathione synthesis and decreasing lipid peroxidation of the liver.	Acetaminophen	95-108	interleukin 1 beta	Mus musculus	133-142
9812850-8	1997	The above results indicate that the preventive effect of IL-1 beta against liver damage due to acetaminophen may be mediated through IL-1 beta receptor by increasing glutathione synthesis and decreasing lipid peroxidation of the liver.	Glutathione	166-177	interleukin 1 beta	Mus musculus	57-66
9812850-8	1997	The above results indicate that the preventive effect of IL-1 beta against liver damage due to acetaminophen may be mediated through IL-1 beta receptor by increasing glutathione synthesis and decreasing lipid peroxidation of the liver.	Glutathione	166-177	interleukin 1 beta	Mus musculus	133-142
9029121-5	1997	Accordingly, the levels of mature IL-1 beta produced in response to turpentine did not differ between wild-type and ICE -/- mice.	Turpentine	68-78	interleukin 1 beta	Mus musculus	34-43
9122256-9	1997	The IL-1beta-deficient mice also responded to LPS challenge with significantly higher serum corticosterone and with lower serum tumor necrosis factor type alpha levels than the wild-type mice.	Corticosterone	92-106	interleukin 1 beta	Mus musculus	4-12
9122256-10	1997	The data suggest that, in the redundant cascade of proinflammatory cytokines, IL-1beta plays an important but not obligatory role in fever induction by LPS or IL-1alpha, as well as in the induction of serum tumor necrosis factor type alpha and corticosterone responses either by LPS or by IL-1alpha or IL-1beta.	Corticosterone	244-258	interleukin 1 beta	Mus musculus	78-86
9038318-6	1997	Antisense oligodeoxynucleotide (ODN) to mannose receptor (MR) mRNA inhibited the expression and function of MR in macrophages as determined by Western blot analysis and 125I-labeled mannose-bovine serum albumin (BSA) binding, and also inhibited the elevation of cytokine IL-1beta, IL-6, and GM-CSF mRNA levels induced by C. albicans attachment.	Oligodeoxyribonucleotides	10-30	interleukin 1 beta	Mus musculus	271-279
9038318-6	1997	Antisense oligodeoxynucleotide (ODN) to mannose receptor (MR) mRNA inhibited the expression and function of MR in macrophages as determined by Western blot analysis and 125I-labeled mannose-bovine serum albumin (BSA) binding, and also inhibited the elevation of cytokine IL-1beta, IL-6, and GM-CSF mRNA levels induced by C. albicans attachment.	Mannose	40-47	interleukin 1 beta	Mus musculus	271-279
9029121-6	1997	In contrast, following zymosan-induced peritonitis, the levels of mature IL-1 beta were significantly lower in ICE -/- mice.	Zymosan	23-30	interleukin 1 beta	Mus musculus	73-82
9029121-8	1997	The reduced production of zymosan-induced mature IL-1 beta in ICE -/- mice was also observed from cultured peritoneal or spleen cells.	Zymosan	26-33	interleukin 1 beta	Mus musculus	49-58
9029121-9	1997	Our results demonstrate that in turpentine-induced tissue necrosis, precursor IL-1 beta is processed by non-ICE proteases, but in complement-mediated inflammation, ICE participates in the processing of the IL-1 beta precursor.	Turpentine	32-42	interleukin 1 beta	Mus musculus	78-87
9003009-6	1997	In DSS mice, IL-1 beta mRNA was elevated in the fed group (954 +/- 155%; P &lt; 0.001), but was suppressed in fasted animals (71.1 +/- 11%).	Dextran Sulfate	3-6	interleukin 1 beta	Mus musculus	13-22
9003009-10	1997	By in situ hybridization, IL-1 beta mRNA was localized to the lamina propria of colonic mucosa in fed DSS animals, but was not detectable in other groups.	Dextran Sulfate	102-105	interleukin 1 beta	Mus musculus	26-35
9195019-11	1997	(2) TCDD failed to change the mRNA expression of TGF-alpha, TGF-beta and TNF-alpha, but led to an increase of IL-1 beta mRNA expression in liver, lung and thymus.	Polychlorinated Dibenzodioxins	4-8	interleukin 1 beta	Mus musculus	110-119
9195019-12	1997	The results show that the TCDD induced IL-1 beta mRNA increase is at least as sensitive a marker as the induction of CYP1A isoforms.	Polychlorinated Dibenzodioxins	26-30	interleukin 1 beta	Mus musculus	39-48
9112083-10	1997	Prednisolone inhibited edematous reactions caused by both IL-1 beta and TNF-alpha.	Prednisolone	0-12	interleukin 1 beta	Mus musculus	58-67
9112083-12	1997	Proinflammatory cytokines, such as IL-1 beta and TNF-alpha, participate in the development of the biphasic cutaneous reaction, especially in its later phase, in mice, and prednisolone inhibits the reaction by suppressing the action of cytokines, at least in part.	Prednisolone	171-183	interleukin 1 beta	Mus musculus	35-44
9014475-3	1996	Marked increase in IL-1 beta and IL-6 was detected in cultured glomeruli of NTN in mice throughout the experiments from disease induction.	ISONICOTINAMIDINE	76-79	interleukin 1 beta	Mus musculus	19-28
8954964-5	1996	These results suggest that, of the three PLA2s expressed in BMMC, type II sPLA2 is the critical enzyme that is coupled with COX-2-dependent PGD2 generation elicited by IgE/Ag in the presence of IL-10 + IL-1beta.	Prostaglandin D2	140-144	interleukin 1 beta	Mus musculus	202-210
9050745-2	1996	CsA caused a dose-related inhibition of interleukin 1beta(IL-1beta) production in both normal and athymic mice, confirming earlier conclusions that this effect is not T cell dependent (ED50s 40 and 53 mg/kg p.o., respectively).	Cyclosporine	0-3	interleukin 1 beta	Mus musculus	40-57
9050745-2	1996	CsA caused a dose-related inhibition of interleukin 1beta(IL-1beta) production in both normal and athymic mice, confirming earlier conclusions that this effect is not T cell dependent (ED50s 40 and 53 mg/kg p.o., respectively).	Cyclosporine	0-3	interleukin 1 beta	Mus musculus	58-66
9050745-8	1996	The present findings support the authors" original hypothesis, that the inhibitory mechanism of CsA on IL-1beta is not mediated via T cells.	Cyclosporine	96-99	interleukin 1 beta	Mus musculus	103-111
9010679-4	1996	TNF and IL-6 were significantly reduced in serum 2 h and 24 h respectively after CLP, interleukin-1 beta (IL-1 beta) was reduced in liver 4 h after CLP, nitric oxide (NO) and serum amyloid A (SAA) were significantly reduced 8 and 24 h respectively after CLP.	Nitric Oxide	153-165	interleukin 1 beta	Mus musculus	86-104
9010679-4	1996	TNF and IL-6 were significantly reduced in serum 2 h and 24 h respectively after CLP, interleukin-1 beta (IL-1 beta) was reduced in liver 4 h after CLP, nitric oxide (NO) and serum amyloid A (SAA) were significantly reduced 8 and 24 h respectively after CLP.	Nitric Oxide	153-165	interleukin 1 beta	Mus musculus	106-115
9010680-4	1996	We found in erythroid cells, originated from the bone marrow precursors obtained from phenylhydrazine-treated mouse, the expression of the following cytokine genes: IL-1 alpha and IL-1 beta, IL-4, IL-6, GM-CSF, gamma-IFN and TGF-beta.	phenylhydrazine	86-101	interleukin 1 beta	Mus musculus	180-189
9088945-1	1997	Nitric oxide has been shown to mediate beta-cell destruction in rodent islets exposed to interleukin 1 beta in culture.	Nitric Oxide	0-12	interleukin 1 beta	Mus musculus	89-107
9003387-0	1996	Cross-linking of the high-affinity IgE receptor induces the expression of cyclo-oxygenase 2 and attendant prostaglandin generation requiring interleukin 10 and interleukin 1 beta in mouse cultured mast cells.	Prostaglandins	106-119	interleukin 1 beta	Mus musculus	160-178
8931762-4	1996	With LPS stimulation, IL-1 beta was elevated in the presence of 500 and 1000 ng/ml of CPA at 1 day and 500, 1000 and 5000 ng/ml at 2 days and 3 days.	cyclopiazonic acid	86-89	interleukin 1 beta	Mus musculus	22-31
8703029-4	1996	The exposure of BMMC to cycloheximide 0.5 h before the addition of the three exogenous cytokines inhibited by approximately 50% the level of IL-6 mRNA generated but did not inhibit the effects of KL + IL-10, indicating that IL-1beta induces the synthesis of a protein that stabilizes IL-6 mRNA.	bmmc	16-20	interleukin 1 beta	Mus musculus	224-232
8956977-4	1996	Semiquantitative reverse transcriptase-polymerase chain reaction analysis revealed that PTX at this dose reduced the mRNA levels for tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 in peripheral blood mononuclear cells (PBMC) of mice with EAE.	Pentoxifylline	88-91	interleukin 1 beta	Mus musculus	168-191
8898726-7	1996	Pretreatment with the anti-inflammatory agent dexamethasone (DEX) reduces the increases of both IL-1 beta and LIF mRNAs following axotomy.	Dexamethasone	46-59	interleukin 1 beta	Mus musculus	96-105
8898726-7	1996	Pretreatment with the anti-inflammatory agent dexamethasone (DEX) reduces the increases of both IL-1 beta and LIF mRNAs following axotomy.	Dexamethasone	61-64	interleukin 1 beta	Mus musculus	96-105
8898726-10	1996	DEX treatment blocks this IL-1 beta-mediated increase in LIF mRNA.	Dexamethasone	0-3	interleukin 1 beta	Mus musculus	26-35
8987109-0	1996	Effects of a 33 residue interleukin-1 beta peptide and the antioxidant PQQ on interleukin-1 beta-mediated inhibition of glucose-stimulated insulin release from cultured mouse pancreatic islets.	PQQ Cofactor	71-74	interleukin 1 beta	Mus musculus	78-96
8987109-0	1996	Effects of a 33 residue interleukin-1 beta peptide and the antioxidant PQQ on interleukin-1 beta-mediated inhibition of glucose-stimulated insulin release from cultured mouse pancreatic islets.	Glucose	120-127	interleukin 1 beta	Mus musculus	24-42
8987109-0	1996	Effects of a 33 residue interleukin-1 beta peptide and the antioxidant PQQ on interleukin-1 beta-mediated inhibition of glucose-stimulated insulin release from cultured mouse pancreatic islets.	Glucose	120-127	interleukin 1 beta	Mus musculus	78-96
8987109-1	1996	Interleukin-1 beta (IL-1 beta) significantly inhibits insulin secretion from glucose stimulated islet cells.	Glucose	77-84	interleukin 1 beta	Mus musculus	0-18
8987109-1	1996	Interleukin-1 beta (IL-1 beta) significantly inhibits insulin secretion from glucose stimulated islet cells.	Glucose	77-84	interleukin 1 beta	Mus musculus	20-29
8703029-5	1996	The stabilization of IL-6 mRNA was inhibited by the addition of actinomycin D at 0.5 but not 3 h after BMMC were stimulated with IL-1beta in combination with KL + IL-10, suggesting that once transcribed, the stabilizing protein is long-lived.	Dactinomycin	64-77	interleukin 1 beta	Mus musculus	129-137
8912886-4	1996	In the joints of CII-immunized mice, IL-1beta and IL-10 mRNA were found in the absence of IL-5 or IFN-gamma.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	17-20	interleukin 1 beta	Mus musculus	37-45
8937427-6	1996	Pretreatment with Zn2+ prior to lipopolysaccharide (LPS) infusion induced an increased heat shock protein 70 and metallothionein expression in the lungs, liver, and kidneys and increased plasma levels of TNF alpha, IL-1 beta, IL-6, and TxB2 as opposed to untreated controls.	Zinc	18-22	interleukin 1 beta	Mus musculus	215-224
8824228-4	1996	We now report that BALB/cJ BMMC stimulated with KL + IL-10 + IL-1beta also exhibit the biphasic release of [3H]arachidonic acid with an immediate phase over the first 10 min followed by a delayed phase from 2 to 7 h. The delayed phase of arachidonic acid release and of PGD2 generation was inhibited by heparin, which concomitantly released a phospholipase (PL) A2 from the cells into the supernatant.	Tritium	108-110	interleukin 1 beta	Mus musculus	61-69
8824228-4	1996	We now report that BALB/cJ BMMC stimulated with KL + IL-10 + IL-1beta also exhibit the biphasic release of [3H]arachidonic acid with an immediate phase over the first 10 min followed by a delayed phase from 2 to 7 h. The delayed phase of arachidonic acid release and of PGD2 generation was inhibited by heparin, which concomitantly released a phospholipase (PL) A2 from the cells into the supernatant.	Arachidonic Acid	111-127	interleukin 1 beta	Mus musculus	61-69
8824228-4	1996	We now report that BALB/cJ BMMC stimulated with KL + IL-10 + IL-1beta also exhibit the biphasic release of [3H]arachidonic acid with an immediate phase over the first 10 min followed by a delayed phase from 2 to 7 h. The delayed phase of arachidonic acid release and of PGD2 generation was inhibited by heparin, which concomitantly released a phospholipase (PL) A2 from the cells into the supernatant.	Arachidonic Acid	238-254	interleukin 1 beta	Mus musculus	61-69
8824228-4	1996	We now report that BALB/cJ BMMC stimulated with KL + IL-10 + IL-1beta also exhibit the biphasic release of [3H]arachidonic acid with an immediate phase over the first 10 min followed by a delayed phase from 2 to 7 h. The delayed phase of arachidonic acid release and of PGD2 generation was inhibited by heparin, which concomitantly released a phospholipase (PL) A2 from the cells into the supernatant.	Heparin	303-310	interleukin 1 beta	Mus musculus	61-69
8824228-6	1996	Transcripts for type IIA PLA2, as assessed by reverse transcription-polymerase chain reaction, were progressively induced in BALB/cJ BMMC treated for 2 to 7 h with KL + IL-10 + IL-1beta; the induction of these transcripts was down-regulated by 10(-6) M dexamethasone.	Dexamethasone	253-266	interleukin 1 beta	Mus musculus	177-185
8903509-3	1996	Tumor necrosis factor-alpha, interleukin 1beta, and nerve growth factor, for example, induce sphingomyelin hydrolysis to ceramide.	Sphingomyelins	93-106	interleukin 1 beta	Mus musculus	29-46
8903509-3	1996	Tumor necrosis factor-alpha, interleukin 1beta, and nerve growth factor, for example, induce sphingomyelin hydrolysis to ceramide.	Ceramides	121-129	interleukin 1 beta	Mus musculus	29-46
8943722-7	1996	However, IL-1 beta, IL-2 and TNF-alpha mRNA levels of lymph node cells from CD4- mice could be upregulated by phorbol myristate acetate in vitro.	Tetradecanoylphorbol Acetate	110-135	interleukin 1 beta	Mus musculus	9-18
8703029-4	1996	The exposure of BMMC to cycloheximide 0.5 h before the addition of the three exogenous cytokines inhibited by approximately 50% the level of IL-6 mRNA generated but did not inhibit the effects of KL + IL-10, indicating that IL-1beta induces the synthesis of a protein that stabilizes IL-6 mRNA.	Cycloheximide	24-37	interleukin 1 beta	Mus musculus	224-232
8895611-5	1996	PGE2 decreased in ibuprofen-treated groups (P &lt; 0.05 versus control, IL-1beta groups).	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	72-80
8809022-3	1996	An increase in intracellular ROS is also demonstrated after growth factor [platelet-derived growth factor (PDGF) or epidermal growth factor (EGF)] or cytokine [tumour necrosis factor-alpha (TNF-alpha) or interleukin (IL)-1 beta] stimulation of NIH 3T3 cells.	Reactive Oxygen Species	29-32	interleukin 1 beta	Mus musculus	204-227
8895611-5	1996	PGE2 decreased in ibuprofen-treated groups (P &lt; 0.05 versus control, IL-1beta groups).	Ibuprofen	18-27	interleukin 1 beta	Mus musculus	72-80
8784134-8	1996	However, after induction of astrocyte iNOS activity with interferon gamma plus lipopolysaccharide or interleukin-1 beta, oxygen-glucose deprivation-induced neuronal injury was markedly enhanced and nitric oxide synthase inhibitors became protective.	oxygen-glucose	121-135	interleukin 1 beta	Mus musculus	101-119
8897766-5	1996	At the present time, it is nuclear how IL-1 beta causes brain injury, but several possible mechanisms include 1) stimulation of an inflammatory response through the activation of glia or the induction of other cytokines and/or endothelial adhesion molecules and 2) release of free radicals through stimulation of arachidonic acid metabolism and/or nitric oxide synthase activity.	Arachidonic Acid	313-329	interleukin 1 beta	Mus musculus	39-48
8931104-7	1996	To determine the inhibitory mechanism of KE-298, we studied the effect of KE-298 on IL-1 beta and TNF-alpha production in mice.	esonarimod	74-80	interleukin 1 beta	Mus musculus	84-93
8931104-8	1996	We found that KE-298 inhibited bacterial lipopolysaccharide (LPS)-induced IL-1 beta production at doses of 50 and 100 mg/kg.	esonarimod	14-20	interleukin 1 beta	Mus musculus	74-83
8931104-11	1996	KE-298 also inhibited the DTH reaction to type II collagen and LPS-induced IL-1 beta production in a dose-related fashion.	esonarimod	0-6	interleukin 1 beta	Mus musculus	75-84
8662965-0	1996	Long exposure to high glucose concentration impairs the responsive expression of gamma-glutamylcysteine synthetase by interleukin-1beta and tumor necrosis factor-alpha in mouse endothelial cells.	Glucose	22-29	interleukin 1 beta	Mus musculus	118-135
8830984-2	1996	The combination of interleukin-1 beta (IL-1) and tumor necrosis factor alpha (TNF) stimulated NO production, PGE2 production, and bone resorption.	Dinoprostone	109-113	interleukin 1 beta	Mus musculus	19-37
8683156-2	1996	The release of 17-kDa IL-1 beta from LPS-activated BALB/c macrophages occurred rapidly after the addition of C57/B1-derived allogeneic CTLs; within 30 min of coculture, mature IL-1 beta was observed in the medium, and maximum release was achieved within 4 h. CTL-induced post-translational processing was efficient, and &gt;80% of newly synthesized pro-IL-1 beta was released into the medium as the 17-kDa species.	17-kda	15-21	interleukin 1 beta	Mus musculus	22-31
8683156-2	1996	The release of 17-kDa IL-1 beta from LPS-activated BALB/c macrophages occurred rapidly after the addition of C57/B1-derived allogeneic CTLs; within 30 min of coculture, mature IL-1 beta was observed in the medium, and maximum release was achieved within 4 h. CTL-induced post-translational processing was efficient, and &gt;80% of newly synthesized pro-IL-1 beta was released into the medium as the 17-kDa species.	17-kda	15-21	interleukin 1 beta	Mus musculus	176-185
8683156-2	1996	The release of 17-kDa IL-1 beta from LPS-activated BALB/c macrophages occurred rapidly after the addition of C57/B1-derived allogeneic CTLs; within 30 min of coculture, mature IL-1 beta was observed in the medium, and maximum release was achieved within 4 h. CTL-induced post-translational processing was efficient, and &gt;80% of newly synthesized pro-IL-1 beta was released into the medium as the 17-kDa species.	17-kda	15-21	interleukin 1 beta	Mus musculus	176-185
8683156-4	1996	In contrast, extracellular ATP promoted mature IL-1 beta release from both macrophage populations.	Adenosine Triphosphate	27-30	interleukin 1 beta	Mus musculus	47-56
8683156-6	1996	An analogue of tenidap, CP-100,829, was more effective as an inhibitor of both IL-1 beta post-translational processing and anion transport.	cp-100	24-30	interleukin 1 beta	Mus musculus	79-88
8781557-2	1996	Prostaglandins E1, E2, and F2 alpha suppressed beta-cell proliferation and long-term insulin secretion, thus mimicking the effects of IL-1 beta.	Alprostadil	0-17	interleukin 1 beta	Mus musculus	134-143
8675313-6	1996	The body temperature decrease by Orn-L was suppressed by anti-interleukin-1beta (IL-1beta) antibody preadministration.	orn-l	33-38	interleukin 1 beta	Mus musculus	81-89
8646768-3	1996	Cultures treated with TNF-alpha (alone or in combination with IL-1 beta) showed several mesenchymal cells with numerous irregularly shaped membrane-bordered cavities containing thick bundled tannic-acid-positive fibrillar structures that resembled loosened collagen fibrils, whereas cells exposed to IL-1 beta alone did not exhibit such changes.	Tannins	191-202	interleukin 1 beta	Mus musculus	62-71
8675173-2	1996	Mouse treatment for 4 hours with 5 microg/kg IL-1beta significantly increased OVA-FITC uptake by HSE.	ova-fitc	78-86	interleukin 1 beta	Mus musculus	45-53
8675173-4	1996	In vitro exposure of mouse HSE to 100 pg/mL LPS or 1 ng/mL IL-1beta for 6 hours significantly (P &lt; .01) increased OVA-FITC uptake.	ova-fitc	117-125	interleukin 1 beta	Mus musculus	59-67
8675173-8	1996	Flow cytometric analysis showed a significant HSE heterogeneity in mannose receptor-mediated endocytosis in response to IL-1beta treatment: type I endothelial cells (EC-I, defined by their small size and high cytoplasmic density) significantly (P &lt; .01) increased OVA-FITC uptake compared with type II endothelial cells (EC-II, defined by their large size and low cytoplasmic density).	ec	166-168	interleukin 1 beta	Mus musculus	120-128
8675173-8	1996	Flow cytometric analysis showed a significant HSE heterogeneity in mannose receptor-mediated endocytosis in response to IL-1beta treatment: type I endothelial cells (EC-I, defined by their small size and high cytoplasmic density) significantly (P &lt; .01) increased OVA-FITC uptake compared with type II endothelial cells (EC-II, defined by their large size and low cytoplasmic density).	ova-fitc	267-275	interleukin 1 beta	Mus musculus	120-128
8632179-0	1996	Interleukin-1 beta induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures.	Prostaglandins	27-40	interleukin 1 beta	Mus musculus	0-18
8632179-3	1996	In cultured mouse astrocytes we observed increased production of prostaglandin E2 (PGE2) after stimulation with either interleukin-1 beta (IL-1 beta) or the protein kinase C activator phorbol 12-myristate 13-acetate (TPA).	Dinoprostone	65-81	interleukin 1 beta	Mus musculus	119-137
8632179-7	1996	Relative to IL-1 beta, the greater increases in PGE2 production and cyclooxygenase activity caused by TPA correlated with a greater induction of PGHS-2 mRNA.	Tetradecanoylphorbol Acetate	102-105	interleukin 1 beta	Mus musculus	12-21
8632179-3	1996	In cultured mouse astrocytes we observed increased production of prostaglandin E2 (PGE2) after stimulation with either interleukin-1 beta (IL-1 beta) or the protein kinase C activator phorbol 12-myristate 13-acetate (TPA).	Dinoprostone	65-81	interleukin 1 beta	Mus musculus	139-148
8632179-3	1996	In cultured mouse astrocytes we observed increased production of prostaglandin E2 (PGE2) after stimulation with either interleukin-1 beta (IL-1 beta) or the protein kinase C activator phorbol 12-myristate 13-acetate (TPA).	Dinoprostone	83-87	interleukin 1 beta	Mus musculus	119-137
8632179-3	1996	In cultured mouse astrocytes we observed increased production of prostaglandin E2 (PGE2) after stimulation with either interleukin-1 beta (IL-1 beta) or the protein kinase C activator phorbol 12-myristate 13-acetate (TPA).	Dinoprostone	83-87	interleukin 1 beta	Mus musculus	139-148
8632179-4	1996	This increase in PGE2 content was blocked by pretreatment with dexamethasone and correlated with increases in cyclooxygenase activity measured at 4 h. Northern blots revealed concomitant increases in PGHS-2 mRNA levels that peaked at 2 h and were dependent on the dosage of IL-1 beta.	Dinoprostone	17-21	interleukin 1 beta	Mus musculus	274-283
8632179-4	1996	This increase in PGE2 content was blocked by pretreatment with dexamethasone and correlated with increases in cyclooxygenase activity measured at 4 h. Northern blots revealed concomitant increases in PGHS-2 mRNA levels that peaked at 2 h and were dependent on the dosage of IL-1 beta.	Dexamethasone	63-76	interleukin 1 beta	Mus musculus	274-283
8632179-5	1996	Dexamethasone inhibited this induction of PGHS-2 mRNA by IL-1 beta.	Dexamethasone	0-13	interleukin 1 beta	Mus musculus	57-66
8832581-0	1996	Interleukin-1 beta and tumor necrosis factor-alpha inhibit the release of [3H]-noradrenaline from mice isolated atria.	Tritium	75-78	interleukin 1 beta	Mus musculus	0-50
8832581-0	1996	Interleukin-1 beta and tumor necrosis factor-alpha inhibit the release of [3H]-noradrenaline from mice isolated atria.	Norepinephrine	79-92	interleukin 1 beta	Mus musculus	0-50
8832581-5	1996	The inhibitory effect of interleukin-1 beta was also abolished by the cyclooxygenase inhibitor, diclofenac (1 mumol/l) suggesting that the action of interleukin-1 beta might be mediated through the formation of prostaglandins.	Diclofenac	96-106	interleukin 1 beta	Mus musculus	25-43
8832581-5	1996	The inhibitory effect of interleukin-1 beta was also abolished by the cyclooxygenase inhibitor, diclofenac (1 mumol/l) suggesting that the action of interleukin-1 beta might be mediated through the formation of prostaglandins.	Diclofenac	96-106	interleukin 1 beta	Mus musculus	149-167
8832581-5	1996	The inhibitory effect of interleukin-1 beta was also abolished by the cyclooxygenase inhibitor, diclofenac (1 mumol/l) suggesting that the action of interleukin-1 beta might be mediated through the formation of prostaglandins.	Prostaglandins	211-225	interleukin 1 beta	Mus musculus	25-43
8832581-5	1996	The inhibitory effect of interleukin-1 beta was also abolished by the cyclooxygenase inhibitor, diclofenac (1 mumol/l) suggesting that the action of interleukin-1 beta might be mediated through the formation of prostaglandins.	Prostaglandins	211-225	interleukin 1 beta	Mus musculus	149-167
8832581-8	1996	The ability of interleukin-1 beta and tumor necrosis factor-alpha to inhibit noradrenaline release suggests that mediators of the immune system produced locally may modulate the activity of the sympathetic nervous system.	Norepinephrine	77-90	interleukin 1 beta	Mus musculus	15-65
8723762-1	1996	Microglia rapidly respond to lipoplysaccharide (LPS) by transformation from resting to active states and secretion of several neuro- and immuno-regulators including tumour necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), and interleukin 6 (IL-6).	lipoplysaccharide	29-46	interleukin 1 beta	Mus musculus	207-225
8613473-1	1996	We have examined H2O2 production by in vitro enriched hepatic sinusoidal endothelium (HSE) during interleukin-1 beta (IL-1 beta) stimulation and B16 melanoma cell adhesion.	Hydrogen Peroxide	17-21	interleukin 1 beta	Mus musculus	98-116
8613473-1	1996	We have examined H2O2 production by in vitro enriched hepatic sinusoidal endothelium (HSE) during interleukin-1 beta (IL-1 beta) stimulation and B16 melanoma cell adhesion.	Hydrogen Peroxide	17-21	interleukin 1 beta	Mus musculus	118-127
8613473-3	1996	Under IL-1 beta treatment there was a 6-fold increase in endothelial cells producing H2O2 (67%) and a 4-fold augmentation in the Kupffer cell population (86%).	Hydrogen Peroxide	85-89	interleukin 1 beta	Mus musculus	6-15
8613473-5	1996	In contrast to the homogeneity of Kupffer cells, H2O2 production intensity was largely heterogeneous in IL-1 beta-activated HSE.	Hydrogen Peroxide	49-53	interleukin 1 beta	Mus musculus	104-113
8613473-7	1996	The addition of increasing concentration of IL-1 beta to HSE for 4 h caused the progressive activation of H2O2 production by treated cells.	Hydrogen Peroxide	106-110	interleukin 1 beta	Mus musculus	44-53
8613473-8	1996	The addition of 80 M excess of IL-1 receptor antagonist (IL-1 Ra) 10 min before IL-1 beta treatment abrogated IL-1 beta-mediated enhancement of H2O2.	Hydrogen Peroxide	144-148	interleukin 1 beta	Mus musculus	80-89
8613473-8	1996	The addition of 80 M excess of IL-1 receptor antagonist (IL-1 Ra) 10 min before IL-1 beta treatment abrogated IL-1 beta-mediated enhancement of H2O2.	Hydrogen Peroxide	144-148	interleukin 1 beta	Mus musculus	110-119
8613473-12	1996	Preincubation of B16 melanoma cells in the presence of 5 micrograms/ml anti-mouse IL-1 beta neutralizing antibody reduced the melanoma cell-induced HSE production of H2O2 by 80%.	Hydrogen Peroxide	166-170	interleukin 1 beta	Mus musculus	82-91
8723762-1	1996	Microglia rapidly respond to lipoplysaccharide (LPS) by transformation from resting to active states and secretion of several neuro- and immuno-regulators including tumour necrosis factor alpha (TNF-alpha), interleukin 1 beta (IL-1 beta), and interleukin 6 (IL-6).	lipoplysaccharide	29-46	interleukin 1 beta	Mus musculus	227-236
8780996-4	1996	As regards cytokine release, amiodarone caused an increase in interleukin-1 (IL-1) alpha, IL-1 beta, and tumor necrosis factor (TNF) alpha release from alveolar macrophages but not from marrow macrophages and monocytes.	Amiodarone	29-39	interleukin 1 beta	Mus musculus	90-99
8852950-8	1996	Northern blot analysis determined that IL-1 beta induced PGHS-2 expression by 30 minutes and mRNA levels were maximal by 1-2 h. Cycloheximide potentiated the accumulation of PGHS-2 mRNA linearly up to 8 h. Dexamethasone, an inhibitor of the induction of PGHS-2, inhibited IL-1 beta-induced PGHS-2 mRNA expression and also suppressed IL-1 beta-stimulated formation of TRAP-positive MNC.	Dexamethasone	206-219	interleukin 1 beta	Mus musculus	272-281
8666901-0	1996	Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone.	trinitrochlorobenzone	73-94	interleukin 1 beta	Mus musculus	18-26
8666901-4	1996	In contrast, IL-1beta-deficient mice showed defective contact hypersensitivity responses to topically applied trinitrochlorobenzene (TNCB).	Picryl Chloride	110-131	interleukin 1 beta	Mus musculus	13-21
8666901-4	1996	In contrast, IL-1beta-deficient mice showed defective contact hypersensitivity responses to topically applied trinitrochlorobenzene (TNCB).	Picryl Chloride	133-137	interleukin 1 beta	Mus musculus	13-21
8613229-3	1996	When myocytes were treated with interleukin-1beta (5 ng/mL), nitrite levels increased, and this effect was inhibited 80% by the specific iNOS inhibitor aminoguanidine.	Nitrites	61-68	interleukin 1 beta	Mus musculus	32-49
8613229-3	1996	When myocytes were treated with interleukin-1beta (5 ng/mL), nitrite levels increased, and this effect was inhibited 80% by the specific iNOS inhibitor aminoguanidine.	pimagedine	152-166	interleukin 1 beta	Mus musculus	32-49
8613229-15	1996	Thus, our data suggest that (1) interleukin-1beta is the primary cytokine in myocyte iNOS regulation and acts predominantly at the transcriptional level; (2) interleukin stimulation of iNOS mRNA and protein is coupled to a tyrosine kinase-mediated signaling pathway; and (3) protein kinase C and cAMP can modify interleukin signaling by decreasing and increasing iNOS, respectively.	Cyclic AMP	296-300	interleukin 1 beta	Mus musculus	32-49
8852950-0	1996	Involvement of prostaglandin endoperoxide H synthase-2 in osteoclast-like cell formation induced by interleukin-1 beta.	Prostaglandins	15-28	interleukin 1 beta	Mus musculus	100-118
8852950-1	1996	Interleukin-1 beta (IL-1 beta) stimulates osteoclast-like cell formation via prostaglandin E2 (PGE2) production.	Dinoprostone	77-93	interleukin 1 beta	Mus musculus	0-18
8852950-1	1996	Interleukin-1 beta (IL-1 beta) stimulates osteoclast-like cell formation via prostaglandin E2 (PGE2) production.	Dinoprostone	77-93	interleukin 1 beta	Mus musculus	20-29
8852950-1	1996	Interleukin-1 beta (IL-1 beta) stimulates osteoclast-like cell formation via prostaglandin E2 (PGE2) production.	Dinoprostone	95-99	interleukin 1 beta	Mus musculus	0-18
8852950-1	1996	Interleukin-1 beta (IL-1 beta) stimulates osteoclast-like cell formation via prostaglandin E2 (PGE2) production.	Dinoprostone	95-99	interleukin 1 beta	Mus musculus	20-29
8852950-4	1996	We report here that IL-1 beta induces PGE2 production in bone marrow culture induced by a PGHS-2-dependent mechanism.	Dinoprostone	38-42	interleukin 1 beta	Mus musculus	20-29
8852950-5	1996	IL-1 beta stimulated the formation of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells (MNC) and the production of PGE2 in mouse bone marrow cultures.	Dinoprostone	139-143	interleukin 1 beta	Mus musculus	0-9
8852950-7	1996	Cycloheximide (CHX) suppressed IL-1 beta-induced PGE2 production, suggesting that the production of PGE2 induced by IL-1 beta required de novo protein synthesis.	Cycloheximide	0-13	interleukin 1 beta	Mus musculus	31-40
8852950-9	1996	Furthermore NS-398, as a selective PGHS-2 inhibitor, completely inhibited IL-1 beta-induced TRAP-positive MNC formation.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	12-18	interleukin 1 beta	Mus musculus	74-83
8852950-7	1996	Cycloheximide (CHX) suppressed IL-1 beta-induced PGE2 production, suggesting that the production of PGE2 induced by IL-1 beta required de novo protein synthesis.	Cycloheximide	0-13	interleukin 1 beta	Mus musculus	116-125
8852950-7	1996	Cycloheximide (CHX) suppressed IL-1 beta-induced PGE2 production, suggesting that the production of PGE2 induced by IL-1 beta required de novo protein synthesis.	Cycloheximide	15-18	interleukin 1 beta	Mus musculus	31-40
8852950-10	1996	Moreover, IL-1 beta-induced PGHS-2 mRNA expression and formation of TRAP-positive MNC were inhibited by calphostin C, a selective inhibitor of protein kinase C (PKC).	calphostin C	104-116	interleukin 1 beta	Mus musculus	10-19
8852950-7	1996	Cycloheximide (CHX) suppressed IL-1 beta-induced PGE2 production, suggesting that the production of PGE2 induced by IL-1 beta required de novo protein synthesis.	Cycloheximide	15-18	interleukin 1 beta	Mus musculus	116-125
8852950-7	1996	Cycloheximide (CHX) suppressed IL-1 beta-induced PGE2 production, suggesting that the production of PGE2 induced by IL-1 beta required de novo protein synthesis.	Dinoprostone	49-53	interleukin 1 beta	Mus musculus	31-40
8852950-7	1996	Cycloheximide (CHX) suppressed IL-1 beta-induced PGE2 production, suggesting that the production of PGE2 induced by IL-1 beta required de novo protein synthesis.	Dinoprostone	49-53	interleukin 1 beta	Mus musculus	116-125
8852950-11	1996	These results indicate that IL-1 beta-induced formation of osteoclast-like cells requires PKC activation, induction of PGHS-2, and subsequent prostaglandin synthesis by this enzyme.	Prostaglandins	142-155	interleukin 1 beta	Mus musculus	28-37
8852950-7	1996	Cycloheximide (CHX) suppressed IL-1 beta-induced PGE2 production, suggesting that the production of PGE2 induced by IL-1 beta required de novo protein synthesis.	Dinoprostone	100-104	interleukin 1 beta	Mus musculus	31-40
8596046-0	1996	Prostaglandin E2 stimulates osteoclast formation via endogenous IL-1 beta expressed through protein kinase A.	Dinoprostone	0-16	interleukin 1 beta	Mus musculus	64-73
8852950-7	1996	Cycloheximide (CHX) suppressed IL-1 beta-induced PGE2 production, suggesting that the production of PGE2 induced by IL-1 beta required de novo protein synthesis.	Dinoprostone	100-104	interleukin 1 beta	Mus musculus	116-125
8852950-8	1996	Northern blot analysis determined that IL-1 beta induced PGHS-2 expression by 30 minutes and mRNA levels were maximal by 1-2 h. Cycloheximide potentiated the accumulation of PGHS-2 mRNA linearly up to 8 h. Dexamethasone, an inhibitor of the induction of PGHS-2, inhibited IL-1 beta-induced PGHS-2 mRNA expression and also suppressed IL-1 beta-stimulated formation of TRAP-positive MNC.	Cycloheximide	128-141	interleukin 1 beta	Mus musculus	39-48
8852950-8	1996	Northern blot analysis determined that IL-1 beta induced PGHS-2 expression by 30 minutes and mRNA levels were maximal by 1-2 h. Cycloheximide potentiated the accumulation of PGHS-2 mRNA linearly up to 8 h. Dexamethasone, an inhibitor of the induction of PGHS-2, inhibited IL-1 beta-induced PGHS-2 mRNA expression and also suppressed IL-1 beta-stimulated formation of TRAP-positive MNC.	Cycloheximide	128-141	interleukin 1 beta	Mus musculus	272-281
8852950-8	1996	Northern blot analysis determined that IL-1 beta induced PGHS-2 expression by 30 minutes and mRNA levels were maximal by 1-2 h. Cycloheximide potentiated the accumulation of PGHS-2 mRNA linearly up to 8 h. Dexamethasone, an inhibitor of the induction of PGHS-2, inhibited IL-1 beta-induced PGHS-2 mRNA expression and also suppressed IL-1 beta-stimulated formation of TRAP-positive MNC.	Cycloheximide	128-141	interleukin 1 beta	Mus musculus	272-281
8852950-8	1996	Northern blot analysis determined that IL-1 beta induced PGHS-2 expression by 30 minutes and mRNA levels were maximal by 1-2 h. Cycloheximide potentiated the accumulation of PGHS-2 mRNA linearly up to 8 h. Dexamethasone, an inhibitor of the induction of PGHS-2, inhibited IL-1 beta-induced PGHS-2 mRNA expression and also suppressed IL-1 beta-stimulated formation of TRAP-positive MNC.	Dexamethasone	206-219	interleukin 1 beta	Mus musculus	39-48
8852950-8	1996	Northern blot analysis determined that IL-1 beta induced PGHS-2 expression by 30 minutes and mRNA levels were maximal by 1-2 h. Cycloheximide potentiated the accumulation of PGHS-2 mRNA linearly up to 8 h. Dexamethasone, an inhibitor of the induction of PGHS-2, inhibited IL-1 beta-induced PGHS-2 mRNA expression and also suppressed IL-1 beta-stimulated formation of TRAP-positive MNC.	Dexamethasone	206-219	interleukin 1 beta	Mus musculus	272-281
8596046-2	1996	PGE2 induced IL-1 beta gene expression in the primed calvarial cells.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	13-22
8596046-3	1996	IL-1 beta gene expression was also induced in a dose-dependent manner by forskolin and dibutyryl cAMP.	Colforsin	73-82	interleukin 1 beta	Mus musculus	0-9
8596046-3	1996	IL-1 beta gene expression was also induced in a dose-dependent manner by forskolin and dibutyryl cAMP.	Bucladesine	87-101	interleukin 1 beta	Mus musculus	0-9
8596046-4	1996	PGE2-induced IL-1 beta gene expression was markedly inhibited by H-89, a potent inhibitor of protein kinase A.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	13-22
8596046-4	1996	PGE2-induced IL-1 beta gene expression was markedly inhibited by H-89, a potent inhibitor of protein kinase A.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	65-69	interleukin 1 beta	Mus musculus	13-22
8596046-7	1996	The presence of the IL-1 beta gene product in the conditioned medium of 1 alpha,25-(OH)2D3-primed calvarial cells treated with PGE2 was proved by the results of an immunoprecipitation assay using anti-mouse IL-1 beta Ab.	Dinoprostone	127-131	interleukin 1 beta	Mus musculus	20-29
8596046-8	1996	The addition of anti-mouse IL-1 beta Ab to 1 alpha,25-(OH)2D3 primed calvarial cell cultures markedly inhibited PGE2-stimulated osteoclast formation.	Dinoprostone	112-116	interleukin 1 beta	Mus musculus	27-36
8596046-9	1996	The stimulatory effect of conditioned medium of primed calvarial cells treated with PGE2 on osteoclast formation was also inhibited by anti-IL-1 beta Ab pretreatment.	Dinoprostone	84-88	interleukin 1 beta	Mus musculus	140-149
7499244-1	1995	In view of the observations that the calcium ionophores, A23187 and ionomycin, enhance the processing and secretion of interleukin-1 (IL-1 alpha) and IL-1 beta from macrophages, and IL-1 alpha processing is mediated by calpain, a calcium-dependent protease, we evaluated the possibility that calpain might also play a role in the processing of IL-1 beta.	Calcium	37-44	interleukin 1 beta	Mus musculus	150-159
8729089-3	1996	The present study further documents the ability of n-3 fatty acids to inhibit cytokine formation, and in part defines the mechanism of the inhibition of production of interleukin-1 beta (IL-1 beta) by dietary n-3 fatty acid.	Fatty Acids, Omega-3	51-66	interleukin 1 beta	Mus musculus	167-185
8729089-3	1996	The present study further documents the ability of n-3 fatty acids to inhibit cytokine formation, and in part defines the mechanism of the inhibition of production of interleukin-1 beta (IL-1 beta) by dietary n-3 fatty acid.	Fatty Acids, Omega-3	51-66	interleukin 1 beta	Mus musculus	187-196
8729089-3	1996	The present study further documents the ability of n-3 fatty acids to inhibit cytokine formation, and in part defines the mechanism of the inhibition of production of interleukin-1 beta (IL-1 beta) by dietary n-3 fatty acid.	Fatty Acids, Omega-3	51-65	interleukin 1 beta	Mus musculus	167-185
8729089-3	1996	The present study further documents the ability of n-3 fatty acids to inhibit cytokine formation, and in part defines the mechanism of the inhibition of production of interleukin-1 beta (IL-1 beta) by dietary n-3 fatty acid.	Fatty Acids, Omega-3	51-65	interleukin 1 beta	Mus musculus	187-196
9011765-2	1996	Levels of IL-1 beta were measured by ELISA in plasma and tissues of mice sacrificed after the administration of LPS or saline.	Sodium Chloride	119-125	interleukin 1 beta	Mus musculus	10-19
9011765-5	1996	In saline-treated mice, adrenalectomy increased IL-1 alpha and IL-1 beta gene expression in the hypothalamus and IL-1 alpha gene expression in the hippocampus and striatum.	Sodium Chloride	3-9	interleukin 1 beta	Mus musculus	63-72
8920166-5	1996	Progesterone (10(-7) M) modestly (40%) reduced the levels of IL-6 mRNA and protein during culture, whereas LPS dramatically (8-fold) and rapidly induced IL-6 and IL-1 beta mRNAs and proteins.	lps	107-110	interleukin 1 beta	Mus musculus	162-171
8920166-9	1996	After LPS injection, IL-1 beta immunopositive cells were dispersed in the myometrium and mesometrial deciduum.	lps	6-9	interleukin 1 beta	Mus musculus	21-30
8618163-3	1996	Macrophage exposure to polymethylmethacrylate particles led to a 9-fold increase in release of tumor necrosis factor alpha (p &lt; 0.01), but did not lead to a significant increase in release of prostaglandin E2, interleukin-1 alpha, or interleukin-1 beta when compared to unexposed cells.	Polymethyl Methacrylate	23-45	interleukin 1 beta	Mus musculus	237-255
8560494-7	1995	We conclude that the IC-21 cell line may represent a suitable model for studying the role of stimulated cytokine gene expression in inflammation and that the early events in the pulmonary inflammatory response to the inhalation of NO2 do not involve stimulated release of TNF-alpha, IL-1 beta or MIP-1 alpha/MIP-1 beta from macrophages.	Nitrogen Dioxide	231-234	interleukin 1 beta	Mus musculus	283-292
8541225-8	1995	An NO synthase inhibitor, L-NG-monomethy-L-arginine (0.5 mM) or aminoguanidine (0.5 mM) abolished increases in NO production induced by combinations of IFN-gamma and TNF-alpha, and IFN-gamma, TNF-alpha and IL-1 beta completely without effects on number of viable cells.	l-ng-monomethy-l-arginine	26-51	interleukin 1 beta	Mus musculus	206-215
8541225-8	1995	An NO synthase inhibitor, L-NG-monomethy-L-arginine (0.5 mM) or aminoguanidine (0.5 mM) abolished increases in NO production induced by combinations of IFN-gamma and TNF-alpha, and IFN-gamma, TNF-alpha and IL-1 beta completely without effects on number of viable cells.	pimagedine	64-78	interleukin 1 beta	Mus musculus	206-215
8786636-5	1995	As regards to the cytokine release, amiodarone caused an increase in interleukin (IL)-1 alpha, IL-1 beta and tumor necrosis factor (TNF) alpha release from macrophages.	Amiodarone	36-46	interleukin 1 beta	Mus musculus	95-104
8890921-4	1996	Hydrocortisone of 1 and 10 mumol/l suppressed TNF-alpha mRNA levels and the TNF-alpha content of beta TC1 cells exposed to IL-1 beta, whereas neither cyclosporin nor FK-506 altered the TNF-alpha content.	Hydrocortisone	0-14	interleukin 1 beta	Mus musculus	123-132
8548860-7	1995	Hydroquinone also inhibits the processing of pre-interleukin-1 beta by interleukin-1 beta convertase.	hydroquinone	0-12	interleukin 1 beta	Mus musculus	49-67
8548860-8	1995	The addition of 2 microM hydroquinone to B1 cells that undergo autocrine stimulation by interleukin-1 beta resulted in the cessation of autocrine cell growth and interleukin-1 beta secretion into the culture medium, as determined by Western immunoblots of the culture supernatants.	hydroquinone	25-37	interleukin 1 beta	Mus musculus	88-106
8548860-8	1995	The addition of 2 microM hydroquinone to B1 cells that undergo autocrine stimulation by interleukin-1 beta resulted in the cessation of autocrine cell growth and interleukin-1 beta secretion into the culture medium, as determined by Western immunoblots of the culture supernatants.	hydroquinone	25-37	interleukin 1 beta	Mus musculus	162-180
8538168-5	1995	IL-1 beta enhanced wound tensile strength (WTS) in TB-irradiated mice, while TGF-beta enhanced WTS in HB-irradiated mice.	Terbium	51-53	interleukin 1 beta	Mus musculus	0-9
8597057-2	1995	Pretreatment of mice with interleukin-1 beta (IL-1) resulted in elevated levels of nitrite/nitrate in serum and rendered mice insensitive towards TNF toxicity.	Nitrites	83-90	interleukin 1 beta	Mus musculus	26-44
8597057-2	1995	Pretreatment of mice with interleukin-1 beta (IL-1) resulted in elevated levels of nitrite/nitrate in serum and rendered mice insensitive towards TNF toxicity.	Nitrates	91-98	interleukin 1 beta	Mus musculus	26-44
8615853-0	1995	Auranofin inhibits the induction of interleukin 1 beta and tumor necrosis factor alpha mRNA in macrophages.	Auranofin	0-9	interleukin 1 beta	Mus musculus	36-54
8615853-2	1995	We demonstrate here that auranofin (AF) (0.1-3 microM), but neither the hydrophilic gold compounds aurothiomalate (ATM) and aurothioglucose nor methotrexate or D-penicillamine, inhibits the induction of interleukin 1 beta and tumor necrosis factor (TNF) alpha mRNA and protein by either zymosan, lipopolysaccharide (LPS), or various bacteria in mouse macrophages.	Auranofin	25-34	interleukin 1 beta	Mus musculus	203-221
8615853-3	1995	The auranofin-mediated inhibition of the induction of TNF-alpha mRNA was stronger than that of interleukin (IL) 1 beta mRNA.	Auranofin	4-13	interleukin 1 beta	Mus musculus	95-118
7499244-1	1995	In view of the observations that the calcium ionophores, A23187 and ionomycin, enhance the processing and secretion of interleukin-1 (IL-1 alpha) and IL-1 beta from macrophages, and IL-1 alpha processing is mediated by calpain, a calcium-dependent protease, we evaluated the possibility that calpain might also play a role in the processing of IL-1 beta.	Calcium	37-44	interleukin 1 beta	Mus musculus	344-353
7499244-1	1995	In view of the observations that the calcium ionophores, A23187 and ionomycin, enhance the processing and secretion of interleukin-1 (IL-1 alpha) and IL-1 beta from macrophages, and IL-1 alpha processing is mediated by calpain, a calcium-dependent protease, we evaluated the possibility that calpain might also play a role in the processing of IL-1 beta.	Calcimycin	57-63	interleukin 1 beta	Mus musculus	150-159
7499244-1	1995	In view of the observations that the calcium ionophores, A23187 and ionomycin, enhance the processing and secretion of interleukin-1 (IL-1 alpha) and IL-1 beta from macrophages, and IL-1 alpha processing is mediated by calpain, a calcium-dependent protease, we evaluated the possibility that calpain might also play a role in the processing of IL-1 beta.	Calcimycin	57-63	interleukin 1 beta	Mus musculus	344-353
7499244-1	1995	In view of the observations that the calcium ionophores, A23187 and ionomycin, enhance the processing and secretion of interleukin-1 (IL-1 alpha) and IL-1 beta from macrophages, and IL-1 alpha processing is mediated by calpain, a calcium-dependent protease, we evaluated the possibility that calpain might also play a role in the processing of IL-1 beta.	Ionomycin	68-77	interleukin 1 beta	Mus musculus	150-159
7499244-1	1995	In view of the observations that the calcium ionophores, A23187 and ionomycin, enhance the processing and secretion of interleukin-1 (IL-1 alpha) and IL-1 beta from macrophages, and IL-1 alpha processing is mediated by calpain, a calcium-dependent protease, we evaluated the possibility that calpain might also play a role in the processing of IL-1 beta.	Ionomycin	68-77	interleukin 1 beta	Mus musculus	344-353
7503324-3	1995	Mice deficient in IL-1 beta had normal circadian rhythm of Tb but were less active than their control counterparts.	Terbium	59-61	interleukin 1 beta	Mus musculus	18-27
7473187-6	1995	In vivo administration of EtOH caused substantial decreases in the SRBC-induced expression of interleukin (IL)-1-beta, IL-2 and IL-4 mRNA in the spleen, as indicated by reverse transcription-polymerase chain reaction.	Ethanol	26-30	interleukin 1 beta	Mus musculus	94-117
8590986-3	1995	administration of interleukin-1 beta (IL-1 beta) attenuates naloxone-precipitated withdrawal jumps in morphine-dependent mice, and the effect was partly mediated by the corticotropin-releasing factor.	Naloxone	60-68	interleukin 1 beta	Mus musculus	18-36
8590986-3	1995	administration of interleukin-1 beta (IL-1 beta) attenuates naloxone-precipitated withdrawal jumps in morphine-dependent mice, and the effect was partly mediated by the corticotropin-releasing factor.	Naloxone	60-68	interleukin 1 beta	Mus musculus	38-47
8590986-3	1995	administration of interleukin-1 beta (IL-1 beta) attenuates naloxone-precipitated withdrawal jumps in morphine-dependent mice, and the effect was partly mediated by the corticotropin-releasing factor.	Morphine	102-110	interleukin 1 beta	Mus musculus	18-36
8590986-3	1995	administration of interleukin-1 beta (IL-1 beta) attenuates naloxone-precipitated withdrawal jumps in morphine-dependent mice, and the effect was partly mediated by the corticotropin-releasing factor.	Morphine	102-110	interleukin 1 beta	Mus musculus	38-47
8590986-4	1995	To elucidate further other possible mechanisms involved in the inhibitory effect of IL-1 beta on morphine withdrawal jumping behaviour, in this study, we examined the involvement of the prostaglandin-synthesis pathway, because prostaglandins have been shown to mediate the several central effects of IL-1.	Morphine	97-105	interleukin 1 beta	Mus musculus	84-93
8590986-12	1995	was significantly blocked by pretreatment with sodium salicylate (a cyclo-oxygenase inhibitor, 10 ng or 30 ng/mouse) administered intracisternally 15 min before IL-1 beta, while i.c.	Sodium Salicylate	47-64	interleukin 1 beta	Mus musculus	161-170
8590986-22	1995	These results indicate that the prostaglandin-synthesis pathway is, at least in part, involved in the inhibitory effect of IL-1 beta on naloxone-precipitated withdrawal jumps in morphine-dependent mice, and that the prostaglandin synthesized in the brain suppresses the morphine withdrawal jumping behaviour via the EP3-receptor, but not via the EP1-, EP2-, IP- or FP-receptor.	Prostaglandins	32-45	interleukin 1 beta	Mus musculus	123-132
8590986-22	1995	These results indicate that the prostaglandin-synthesis pathway is, at least in part, involved in the inhibitory effect of IL-1 beta on naloxone-precipitated withdrawal jumps in morphine-dependent mice, and that the prostaglandin synthesized in the brain suppresses the morphine withdrawal jumping behaviour via the EP3-receptor, but not via the EP1-, EP2-, IP- or FP-receptor.	Naloxone	136-144	interleukin 1 beta	Mus musculus	123-132
8590986-22	1995	These results indicate that the prostaglandin-synthesis pathway is, at least in part, involved in the inhibitory effect of IL-1 beta on naloxone-precipitated withdrawal jumps in morphine-dependent mice, and that the prostaglandin synthesized in the brain suppresses the morphine withdrawal jumping behaviour via the EP3-receptor, but not via the EP1-, EP2-, IP- or FP-receptor.	Morphine	178-186	interleukin 1 beta	Mus musculus	123-132
8590986-22	1995	These results indicate that the prostaglandin-synthesis pathway is, at least in part, involved in the inhibitory effect of IL-1 beta on naloxone-precipitated withdrawal jumps in morphine-dependent mice, and that the prostaglandin synthesized in the brain suppresses the morphine withdrawal jumping behaviour via the EP3-receptor, but not via the EP1-, EP2-, IP- or FP-receptor.	Morphine	270-278	interleukin 1 beta	Mus musculus	123-132
7473187-6	1995	In vivo administration of EtOH caused substantial decreases in the SRBC-induced expression of interleukin (IL)-1-beta, IL-2 and IL-4 mRNA in the spleen, as indicated by reverse transcription-polymerase chain reaction.	srbc	67-71	interleukin 1 beta	Mus musculus	94-117
7499497-4	1995	The enhanced release of IL-1 beta caused by ME or LPS was partially blocked by naloxone.	Naloxone	79-87	interleukin 1 beta	Mus musculus	24-33
7673730-9	1995	The results from Cl2MBP-liposome-treated mice also suggested that splenic macrophages were the primary producers of LPS-induced IL-1 beta, IL-6, IL-12 (p40), and IL-1 receptor antagonist (IL-1ra) mRNA, but not IL-10 and TNF-alpha mRNA.	cl2mbp	17-23	interleukin 1 beta	Mus musculus	128-137
7499497-1	1995	In the present study, functional interactions between [Met5]-enkephalin (ME), naloxone and lipopolysaccharide (LPS) on interleukin-1 beta (IL-1 beta) immunostaining and secretion have been assessed in mixed brain cell cultures from embryonic day 17 mice.	Naloxone	78-86	interleukin 1 beta	Mus musculus	119-137
7593555-8	1995	Production of nitrite by CM-exposed RAW 264.7 cells was blocked by inhibitors of NOS (L-N-methylarginine or aminoguanidine) or by antibodies to murine IFN-gamma or IL-1 beta.	Nitrites	14-21	interleukin 1 beta	Mus musculus	164-173
7653558-3	1995	Microinjection of RX-77368 (30 ng) into the right DVC with mIL-1 beta microinjected either into the right (100, 250 pg) or into the left (100, 500 pg) DVC inhibited gastric contractility for 30-120 min postinjection.	cyqualon	50-53	interleukin 1 beta	Mus musculus	59-69
7650365-2	1995	One such lipid, ceramide, generated from membrane sphingomyelin following stimulation with TNF-alpha, IL-1 beta, or IFN-gamma, activates ceramide-activated kinase (CAK).	Ceramides	16-24	interleukin 1 beta	Mus musculus	102-111
7650365-2	1995	One such lipid, ceramide, generated from membrane sphingomyelin following stimulation with TNF-alpha, IL-1 beta, or IFN-gamma, activates ceramide-activated kinase (CAK).	Sphingomyelins	50-63	interleukin 1 beta	Mus musculus	102-111
8527742-3	1995	Administration of IL-2 (5.0 micrograms kg-1) induced a slight but statistically significant increase in glutamine concentrations in both brain areas, while similar administration of IL-1 beta (20 micrograms kg-1) significantly reduced the hippocampal levels of glutamine, glutamic acid and GABA.	Glutamine	261-270	interleukin 1 beta	Mus musculus	182-191
8527742-3	1995	Administration of IL-2 (5.0 micrograms kg-1) induced a slight but statistically significant increase in glutamine concentrations in both brain areas, while similar administration of IL-1 beta (20 micrograms kg-1) significantly reduced the hippocampal levels of glutamine, glutamic acid and GABA.	Glutamic Acid	272-285	interleukin 1 beta	Mus musculus	182-191
8527742-3	1995	Administration of IL-2 (5.0 micrograms kg-1) induced a slight but statistically significant increase in glutamine concentrations in both brain areas, while similar administration of IL-1 beta (20 micrograms kg-1) significantly reduced the hippocampal levels of glutamine, glutamic acid and GABA.	gamma-Aminobutyric Acid	290-294	interleukin 1 beta	Mus musculus	182-191
7579150-5	1995	Following stimulation with dibutyryl-cyclic AMP or interferon-gamma in combination with either lipopolysaccharide or interleukin-1 beta, there was a marked increase in NF1 mRNA and protein expression.	Bucladesine	27-47	interleukin 1 beta	Mus musculus	117-135
7664775-6	1995	Finally, LPS-triggered IL-1 beta secretion by XS cells is blocked almost completely by the ICE inhibitor acetyl-Tyr-Val-Ala-Asp-CH2OC(O)-[2,6-(CF3)2]Ph.	acetyl-tyr-val-ala-asp-ch2oc	105-133	interleukin 1 beta	Mus musculus	23-32
8581523-3	1995	TNF alpha and IL-1 beta reached a peak concentrations at 3 and 6 h respectively after zymosan injection.	Zymosan	86-93	interleukin 1 beta	Mus musculus	14-23
8581523-7	1995	Prednisolone inhibited IL-1 beta at 72 h post-zymosan.	Prednisolone	0-12	interleukin 1 beta	Mus musculus	23-32
8581523-7	1995	Prednisolone inhibited IL-1 beta at 72 h post-zymosan.	Zymosan	46-53	interleukin 1 beta	Mus musculus	23-32
7631887-0	1995	Corticosterone regulates behavioral effects of lipopolysaccharide and interleukin-1 beta in mice.	Corticosterone	0-14	interleukin 1 beta	Mus musculus	70-88
7608192-8	1995	Mutagenesis of the mature IL-1 beta sequence revealed that a region of basic amino acids may play an important role in the optimal secretion of mature IL-1 beta in P388D1 cells, but not in Jurkat cells.	Amino Acids, Basic	71-88	interleukin 1 beta	Mus musculus	26-35
7608192-8	1995	Mutagenesis of the mature IL-1 beta sequence revealed that a region of basic amino acids may play an important role in the optimal secretion of mature IL-1 beta in P388D1 cells, but not in Jurkat cells.	Amino Acids, Basic	71-88	interleukin 1 beta	Mus musculus	151-160
8569283-0	1995	Age-dependent stimulation or inhibition of calcium release from bone cultures by interleukin-1 beta.	Calcium	43-50	interleukin 1 beta	Mus musculus	81-99
7631887-4	1995	Chronic replacement with a 15-mg corticosterone pellet abrogated the enhanced susceptibility of adrenalectomized animals to 200 ng of IL-1 beta but had only partial protective effects on their response to 400 ng of IL-1 beta and LPS.	Corticosterone	33-47	interleukin 1 beta	Mus musculus	134-143
7631887-4	1995	Chronic replacement with a 15-mg corticosterone pellet abrogated the enhanced susceptibility of adrenalectomized animals to 200 ng of IL-1 beta but had only partial protective effects on their response to 400 ng of IL-1 beta and LPS.	Corticosterone	33-47	interleukin 1 beta	Mus musculus	215-224
7590611-2	1995	We have investigated the effect of type I diabetes mellitus and insulin treatment on tissue levels of IL-1 beta using streptozotocin (STZ)-treated mouse as an animal model.	Streptozocin	134-137	interleukin 1 beta	Mus musculus	102-111
7476020-0	1995	Expression of interleukin 1 alpha, interleukin 1 beta and interleukin 1 receptor antagonist mRNA in mouse brain: regulation by bacterial lipopolysaccharide (LPS) treatment.	bacterial lipopolysaccharide	127-155	interleukin 1 beta	Mus musculus	35-91
7590611-4	1995	For example, IL-1 beta levels (as measured by ELISA) were markedly decreased in the liver and spleen of the STZ diabetic mice.	Streptozocin	108-111	interleukin 1 beta	Mus musculus	13-22
7597700-3	1995	Specifically, IL-1 beta and IL-6 mRNA levels increased in spleen and PP following exposure to VT.	deoxynivalenol	94-96	interleukin 1 beta	Mus musculus	14-23
7621081-5	1995	In contrast, when challenged with turpentine, which causes localized inflammation and tissue injury, the IL-1 beta mutant mice exhibited an impaired acute-phase inflammatory response and were completely resistant to fever development and anorexia.	Turpentine	34-44	interleukin 1 beta	Mus musculus	105-114
7648334-5	1995	Dantrolene and azumolene decreased IL-1 alpha by 56.6 and 65.4%, respectively, (p &lt; .05) and IL-1 beta by 51.7 and 69.7%, respectively (p &lt; .05).	Dantrolene	0-10	interleukin 1 beta	Mus musculus	96-105
7556877-0	1995	Interleukin-1 beta-induced stimulation of insulin release in mouse pancreatic islets is related to diacylglycerol production and protein kinase C activation.	Diglycerides	99-113	interleukin 1 beta	Mus musculus	0-18
7637154-0	1995	[Milrinone suppresses TNF-alpha and IL-1 beta release in mouse peritoneal macrophages].	Milrinone	1-10	interleukin 1 beta	Mus musculus	36-45
7637154-2	1995	We studied whether milrinone suppresses TNF-alpha and IL-1 beta releases from mouse peritoneal macrophages.	Milrinone	19-28	interleukin 1 beta	Mus musculus	54-63
7637154-5	1995	Release of IL-1 beta was not suppressed with 25 microM of milrinone, but it was suppressed with 250 microM of milrinone.	Milrinone	110-119	interleukin 1 beta	Mus musculus	11-20
7667201-0	1995	Effect of liposomal and free bisphosphonates on the IL-1 beta, IL-6 and TNF alpha secretion from RAW 264 cells in vitro.	Diphosphonates	29-44	interleukin 1 beta	Mus musculus	52-61
7671998-0	1995	Intracisternal administration of interleukin-1 beta attenuates naloxone-precipitated withdrawal in morphine-dependent mice.	Naloxone	63-71	interleukin 1 beta	Mus musculus	33-51
7671998-0	1995	Intracisternal administration of interleukin-1 beta attenuates naloxone-precipitated withdrawal in morphine-dependent mice.	Morphine	99-107	interleukin 1 beta	Mus musculus	33-51
7671998-1	1995	The effect of central administration of interleukin-1 beta on naloxone-precipitated withdrawal in morphine-dependent mice was studied.	Naloxone	62-70	interleukin 1 beta	Mus musculus	40-58
7671998-1	1995	The effect of central administration of interleukin-1 beta on naloxone-precipitated withdrawal in morphine-dependent mice was studied.	Morphine	98-106	interleukin 1 beta	Mus musculus	40-58
7671998-4	1995	administration of interleukin-1 beta (0.01-1 ng/5 microliters per mouse) to morphine-dependent mice 30 min prior to the injection of naloxone (10 mg/kg i.p.)	Morphine	76-84	interleukin 1 beta	Mus musculus	18-36
7671998-7	1995	These results suggest that centrally administered interleukin-1 beta could attenuate naloxone-precipitated withdrawal in morphine-dependent mice via interleukin-1 receptors in the brain.	Naloxone	85-93	interleukin 1 beta	Mus musculus	50-68
7671998-7	1995	These results suggest that centrally administered interleukin-1 beta could attenuate naloxone-precipitated withdrawal in morphine-dependent mice via interleukin-1 receptors in the brain.	Morphine	121-129	interleukin 1 beta	Mus musculus	50-68
7704969-4	1995	After 2 days of treatment, misoprostol reduced renal cortical interleukin-1 beta (IL-1 beta) mRNA levels compared to vehicle-treated controls (0.19 +/- 0.06 (misoprostol) vs 0.50 +/- 0.04 (vehicle) densitometry units; P &lt; 0.005).	Misoprostol	27-38	interleukin 1 beta	Mus musculus	62-80
7704969-4	1995	After 2 days of treatment, misoprostol reduced renal cortical interleukin-1 beta (IL-1 beta) mRNA levels compared to vehicle-treated controls (0.19 +/- 0.06 (misoprostol) vs 0.50 +/- 0.04 (vehicle) densitometry units; P &lt; 0.005).	Misoprostol	27-38	interleukin 1 beta	Mus musculus	82-91
7704969-5	1995	A similar reduction in cortical IL-1 beta mRNA levels was found in left kidneys harvested from MRL-lpr/lpr mice following 2 days of treatment with misoprostol compared to right kidneys harvested from the same animal prior to the first dose of PGE1 analog (0.12 +/- .05 (left) vs 0.39 +/- 0.18 (right) densitometry units; P &lt; 0.05).	Misoprostol	147-158	interleukin 1 beta	Mus musculus	32-41
7704969-5	1995	A similar reduction in cortical IL-1 beta mRNA levels was found in left kidneys harvested from MRL-lpr/lpr mice following 2 days of treatment with misoprostol compared to right kidneys harvested from the same animal prior to the first dose of PGE1 analog (0.12 +/- .05 (left) vs 0.39 +/- 0.18 (right) densitometry units; P &lt; 0.05).	Alprostadil	243-247	interleukin 1 beta	Mus musculus	32-41
7704969-7	1995	Time-course studies indicated that IL-1 beta mRNA levels were decreased within 24 hr of initiating misoprostol therapy.	Misoprostol	99-110	interleukin 1 beta	Mus musculus	35-44
7704969-8	1995	This reduction in IL-1 beta mRNA levels was transient because levels were not reduced after 1 week of treatment with the PGE1 analog.	Alprostadil	121-125	interleukin 1 beta	Mus musculus	18-27
7648334-0	1995	Calcium antagonists decrease plasma and tissue concentrations of tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-1 alpha in a mouse model of endotoxin.	Calcium	0-7	interleukin 1 beta	Mus musculus	94-112
7648334-5	1995	Dantrolene and azumolene decreased IL-1 alpha by 56.6 and 65.4%, respectively, (p &lt; .05) and IL-1 beta by 51.7 and 69.7%, respectively (p &lt; .05).	azumolene	15-24	interleukin 1 beta	Mus musculus	96-105
7695923-4	1995	Hemorrhaged mice treated with the oxygen radical scavenger dimethylthiourea (DMTU) had decreased levels of mRNA for IL-1 beta in pulmonary mononuclear cells, compared with hemorrhaged controls (P &lt; 0.05).	Oxygen	34-40	interleukin 1 beta	Mus musculus	116-125
7695923-4	1995	Hemorrhaged mice treated with the oxygen radical scavenger dimethylthiourea (DMTU) had decreased levels of mRNA for IL-1 beta in pulmonary mononuclear cells, compared with hemorrhaged controls (P &lt; 0.05).	1,3-dimethylthiourea	59-75	interleukin 1 beta	Mus musculus	116-125
7695923-4	1995	Hemorrhaged mice treated with the oxygen radical scavenger dimethylthiourea (DMTU) had decreased levels of mRNA for IL-1 beta in pulmonary mononuclear cells, compared with hemorrhaged controls (P &lt; 0.05).	1,3-dimethylthiourea	77-81	interleukin 1 beta	Mus musculus	116-125
7695923-5	1995	In hemorrhaged mice depleted of xanthine oxidase (XO) by a tungsten-enriched diet, pulmonary mononuclear cell mRNA levels for IL-1 beta and TNF-alpha were significantly decreased (P &lt; 0.01 and 0.05, respectively), compared with cells from hemorrhaged control mice fed a normal diet.	Tungsten	59-67	interleukin 1 beta	Mus musculus	126-135
7695923-6	1995	Similarly, mRNA transcripts for IL-1 beta and TNF-alpha among pulmonary mononuclear cells from hemorrhaged mice treated with allopurinol, an inhibitor of XO, were also significantly reduced (P &lt; 0.05 and 0.001, respectively), compared with hemorrhaged control mice not treated with allopurinol.	Allopurinol	125-136	interleukin 1 beta	Mus musculus	32-41
7695923-6	1995	Similarly, mRNA transcripts for IL-1 beta and TNF-alpha among pulmonary mononuclear cells from hemorrhaged mice treated with allopurinol, an inhibitor of XO, were also significantly reduced (P &lt; 0.05 and 0.001, respectively), compared with hemorrhaged control mice not treated with allopurinol.	Allopurinol	285-296	interleukin 1 beta	Mus musculus	32-41
7695923-7	1995	Our results indicate that XO-derived oxygen radicals contribute to the increased expression of mRNA for IL-1 beta and TNF-alpha, which occurs among pulmonary mononuclear cell populations immediately after hemorrhage.	Reactive Oxygen Species	37-52	interleukin 1 beta	Mus musculus	104-113
7706480-7	1995	Measured by nitrite production, transfected HIT, and NIT-1 cells exhibited a more than 10-fold decrease in IL-1 beta sensitivity.	Nitrites	12-19	interleukin 1 beta	Mus musculus	107-116
7890375-5	1995	PCR analysis revealed that interleukin 6 (IL-6) and IL-1 beta gene expression occurs in brain of HCN-treated mice but not in brains of saline-treated controls.	Hydrogen Cyanide	97-100	interleukin 1 beta	Mus musculus	52-61
7876552-5	1995	Injection of ATP 2 h after LPS led to the rapid extracellular release of IL-1 beta, IL-1 alpha, lactate dehydrogenase, and beta-N-acetylglucosaminidase.	Adenosine Triphosphate	13-16	interleukin 1 beta	Mus musculus	73-82
7536360-7	1995	Additionally, cadmium exposure increased IL-1 alpha, IL-1 beta, TNF-alpha, MIP-2, IL-6, and ICAM-1 mRNA transcripts in the liver.	Cadmium	14-21	interleukin 1 beta	Mus musculus	53-62
7536171-1	1995	Interleukin-1 beta (IL-1 beta) has been suggested to mediate beta-cell destruction in insulin-dependent diabetes mellitus (IDDM) by inducing nitric oxide production.	Nitric Oxide	141-153	interleukin 1 beta	Mus musculus	0-18
7536171-1	1995	Interleukin-1 beta (IL-1 beta) has been suggested to mediate beta-cell destruction in insulin-dependent diabetes mellitus (IDDM) by inducing nitric oxide production.	Nitric Oxide	141-153	interleukin 1 beta	Mus musculus	20-29
7536171-10	1995	However, after incubation with IL-1 beta in vitro, both NOD and NMRI islets responded with a marked increase in nitric oxide production.	Nitric Oxide	112-124	interleukin 1 beta	Mus musculus	31-40
7822802-0	1995	Inhibition of mature IL-1 beta production in murine macrophages and a murine model of inflammation by WIN 67694, an inhibitor of IL-1 beta converting enzyme.	WIN 67694	102-111	interleukin 1 beta	Mus musculus	21-30
7844376-6	1995	Chlorpromazine also significantly reduced IL-1 beta and soluble TNF receptor-P75.	Chlorpromazine	0-14	interleukin 1 beta	Mus musculus	42-51
7822802-3	1995	In activated murine peritoneal macrophages, WIN 67694 inhibited the release of mature IL-1 beta with an IC50 of 1.8 microM without any effect on the release of IL-1 alpha, IL-6, or TNF-alpha.	WIN 67694	44-53	interleukin 1 beta	Mus musculus	86-95
7822802-5	1995	In vivo, WIN 67694 was also able to inhibit selectively the release of IL-1 beta in a dose-dependent manner in a subcutaneous tissue chamber implant model of inflammation.	WIN 67694	9-18	interleukin 1 beta	Mus musculus	71-80
7723245-6	1995	In contrast, pre-incubating calvariae with either anti-IL-1 beta or IL-1 beta RA did not alter basal calcium efflux but completely blocked the beta 2m induced calcium efflux.	Radium	78-80	interleukin 1 beta	Mus musculus	68-77
7723245-6	1995	In contrast, pre-incubating calvariae with either anti-IL-1 beta or IL-1 beta RA did not alter basal calcium efflux but completely blocked the beta 2m induced calcium efflux.	Calcium	159-166	interleukin 1 beta	Mus musculus	55-64
7723245-6	1995	In contrast, pre-incubating calvariae with either anti-IL-1 beta or IL-1 beta RA did not alter basal calcium efflux but completely blocked the beta 2m induced calcium efflux.	Calcium	159-166	interleukin 1 beta	Mus musculus	68-77
7723245-8	1995	Thus, the beta 2m-induced calcium efflux observed in neonatal mouse calvariae is dependent on interleukin-1 beta but not prostaglandins.	Calcium	26-33	interleukin 1 beta	Mus musculus	94-112
7536045-7	1995	A possible role for ovarian steroids in the modulation of IL-1 beta expression in the endometrium is suggested by the increase in IL-1 beta mRNA that occurs in late secretory endometrium and by the induction of IL-1 by estrogen and progesterone in the mouse uterus.	Steroids	28-36	interleukin 1 beta	Mus musculus	58-67
7740051-0	1995	IL-1 beta and TNF alpha modulate delta 9-tetrahydrocannabinol-induced catalepsy in mice.	Dronabinol	33-61	interleukin 1 beta	Mus musculus	0-9
7740051-2	1995	Recombinant IL-1 beta (400 ng/mouse, IV) and TNF alpha (500 ng/mouse, IV) were effective in potentiating the cataleptic effect of low-dose THC (10 micrograms/mouse, IV).	Dronabinol	139-142	interleukin 1 beta	Mus musculus	12-21
7740051-4	1995	Anti-IL-1 beta and anti-TNF alpha antibodies were effective in attenuating high-dose (75 micrograms/mouse) THC-induced catalepsy.	Dronabinol	107-110	interleukin 1 beta	Mus musculus	5-14
7536045-7	1995	A possible role for ovarian steroids in the modulation of IL-1 beta expression in the endometrium is suggested by the increase in IL-1 beta mRNA that occurs in late secretory endometrium and by the induction of IL-1 by estrogen and progesterone in the mouse uterus.	Steroids	28-36	interleukin 1 beta	Mus musculus	130-139
7536045-7	1995	A possible role for ovarian steroids in the modulation of IL-1 beta expression in the endometrium is suggested by the increase in IL-1 beta mRNA that occurs in late secretory endometrium and by the induction of IL-1 by estrogen and progesterone in the mouse uterus.	Progesterone	232-244	interleukin 1 beta	Mus musculus	58-67
18475654-6	1995	Forskolin, for example, induced expression PDGF B chain mRNA to a level ranging from 25% to 200% of the level induced by LPS in 6 h. In contrast, cAMP-inducers enhance the expression of IL-1beta and TNF-alpha mRNAs, but only in the presence of LPS.	Colforsin	0-9	interleukin 1 beta	Mus musculus	186-194
18475654-6	1995	Forskolin, for example, induced expression PDGF B chain mRNA to a level ranging from 25% to 200% of the level induced by LPS in 6 h. In contrast, cAMP-inducers enhance the expression of IL-1beta and TNF-alpha mRNAs, but only in the presence of LPS.	Cyclic AMP	146-150	interleukin 1 beta	Mus musculus	186-194
7987845-0	1994	Combined interleukin-1 beta/interleukin-6 treatment in mice: synergistic myelostimulatory activity and myelorestorative effect after cyclophosphamide-induced myelosuppression.	Cyclophosphamide	133-149	interleukin 1 beta	Mus musculus	9-27
7799917-13	1995	UV cross-linking and sodium dodecyl sulfate-polyacrylamide electrophoresis identified an IL1 beta -UNF1-specific binding factor approximately 85 to 90 kDa in size.	Sodium Dodecyl Sulfate	21-43	interleukin 1 beta	Mus musculus	89-103
7799917-13	1995	UV cross-linking and sodium dodecyl sulfate-polyacrylamide electrophoresis identified an IL1 beta -UNF1-specific binding factor approximately 85 to 90 kDa in size.	polyacrylamide	44-58	interleukin 1 beta	Mus musculus	89-103
7660807-8	1995	In mice without restraint stress, both the suppressive factor in serum and in lymph node were found to be induced in dose-dependent manner by icv injection of IL-1 beta.	icv	142-145	interleukin 1 beta	Mus musculus	159-168
7987845-7	1994	Furthermore, combined treatment with IL-1 beta/IL-6 accelerated and potentiated the recovery of myeloid cells after cyclophosphamide injection, whereas the single regimen treatment was not effective.	Cyclophosphamide	116-132	interleukin 1 beta	Mus musculus	37-46
7834243-6	1994	The level of interleukin-1b (IL-1b) measured by ELISA was the highest in the amoeba infected group without silica injection and the lowest in the amoeba infected group with silica administration.	Silicon Dioxide	107-113	interleukin 1 beta	Mus musculus	13-27
7798624-1	1994	Acute disruption of the permeability barrier by either tape stripping or acetone treatment and chronic disruption by feeding an essential fatty acid-deficient diet increase the mRNA levels of tumor necrosis factor-alpha (TNF alpha), interleukin (IL)-1 alpha, IL-1 beta, IL-1ra, and granulocyte/macrophage-colony-stimulating factor in murine epidermis.	Fatty Acids, Essential	128-148	interleukin 1 beta	Mus musculus	259-268
7528993-4	1994	Northern blot analysis using cDNA for mouse liver iNOS as a probe showed that IL-1 beta induced expression of iNOS mRNA and stimulated NOx production in a dose- and time-dependent manner.	nicotine 1-N-oxide	135-138	interleukin 1 beta	Mus musculus	78-87
7834243-6	1994	The level of interleukin-1b (IL-1b) measured by ELISA was the highest in the amoeba infected group without silica injection and the lowest in the amoeba infected group with silica administration.	Silicon Dioxide	107-113	interleukin 1 beta	Mus musculus	29-34
7834243-6	1994	The level of interleukin-1b (IL-1b) measured by ELISA was the highest in the amoeba infected group without silica injection and the lowest in the amoeba infected group with silica administration.	Silicon Dioxide	173-179	interleukin 1 beta	Mus musculus	13-27
7834243-6	1994	The level of interleukin-1b (IL-1b) measured by ELISA was the highest in the amoeba infected group without silica injection and the lowest in the amoeba infected group with silica administration.	Silicon Dioxide	173-179	interleukin 1 beta	Mus musculus	29-34
8051418-5	1994	Previously, ATP was shown to promote the release and proteolytic maturation of IL-1 beta from LPS-stimulated murine peritoneal macrophages.	Adenosine Triphosphate	12-15	interleukin 1 beta	Mus musculus	79-88
7828414-3	1994	However the addition of IL-1 alpha, IL1-beta and gamma IFN (3.3 x 10(-8) gl-1) caused a significant (P &lt; 0.01) inhibition of EPO stimulated thymidine incorporation.	Thymidine	143-152	interleukin 1 beta	Mus musculus	36-44
7868298-5	1994	In a cell-free system, suramin prevents the binding of IL-1 alpha and IL-1 beta to murine and human recombinant soluble type I IL-1 receptors.	Suramin	23-30	interleukin 1 beta	Mus musculus	70-79
7704934-0	1994	Potential role for phosphatidic acid in mediating the inflammatory responses to TNF alpha and IL-1 beta.	Phosphatidic Acids	19-36	interleukin 1 beta	Mus musculus	94-103
7704934-5	1994	Intracellular PA species, which may have intracellular signaling functions, are rapidly induced in P388 monocytic leukemia cells by TNF alpha, IL-1 beta, or LPS.	Phosphatidic Acids	14-16	interleukin 1 beta	Mus musculus	143-152
7704934-8	1994	Lisofylline [(R)-1-(5-hydroxyhexyl)-3,7-dimethylxanthine; LSF] selectively inhibits generation of selected species of PA in P388 cells induced by TNF alpha, IL-1 beta or LPS.	lisofylline	0-11	interleukin 1 beta	Mus musculus	157-166
7704934-8	1994	Lisofylline [(R)-1-(5-hydroxyhexyl)-3,7-dimethylxanthine; LSF] selectively inhibits generation of selected species of PA in P388 cells induced by TNF alpha, IL-1 beta or LPS.	lisofylline	13-56	interleukin 1 beta	Mus musculus	157-166
8051418-6	1994	Tenidap, a new anti-inflammatory and antiarthritic agent, inhibited the release and maturation of IL-1 beta induced in vitro by ATP treatment of murine peritoneal macrophages.	Adenosine Triphosphate	128-131	interleukin 1 beta	Mus musculus	98-107
7520256-3	1994	However, following activation of inducible NOS in astrocytes by interleukin-1 beta plus interferon-gamma, NMDA but not kainate neurotoxicity was markedly potentiated.	N-Methylaspartate	106-110	interleukin 1 beta	Mus musculus	64-82
7932187-8	1994	These results showed THC treatment had no effect on the level of ETX-induced intracellular promature IL1 alpha and IL1 beta proteins; however, a THC-induced increase and prolongation of release of promature IL1 alpha and mature IL1 beta were observed.	Dronabinol	145-148	interleukin 1 beta	Mus musculus	228-236
7932187-10	1994	These results suggest THC augments the ETX-induced processing of IL1 beta and release of IL1 alpha rather than increasing the cellular production of IL1 protein.	Dronabinol	22-25	interleukin 1 beta	Mus musculus	65-73
9397943-13	1994	IL-1beta alone in concentrations of 0.1, 1 and 10 ng/ml inhibited testosterone formation by 45%, 62% and 91%, respectively, in the presence of TNF-alpha (10 ng/ml), IL-1beta in a concentration as low as 0.1 ng/ml completely blocked hCG-induced testosterone formation.	Testosterone	66-78	interleukin 1 beta	Mus musculus	0-8
8048078-5	1994	Intraperitoneal administration of recombinant IL-1 beta (0.4 U) or TNF alpha (10 ng) resulted in an enhanced peritoneal inflammatory response compared to phosphate-buffered saline-injected control animals measured 20 hr following injection of SRBC.	Phosphate-Buffered Saline	154-179	interleukin 1 beta	Mus musculus	46-55
8048078-5	1994	Intraperitoneal administration of recombinant IL-1 beta (0.4 U) or TNF alpha (10 ng) resulted in an enhanced peritoneal inflammatory response compared to phosphate-buffered saline-injected control animals measured 20 hr following injection of SRBC.	srbc	243-247	interleukin 1 beta	Mus musculus	46-55
8029644-0	1994	IFN-gamma inhibits internalization of soluble aminated beta-1,3-D-glucan by macrophages and thereby down-regulates the glucan induced release of TNF-alpha and IL-1 beta.	(1----3)-beta-d-glucan	55-72	interleukin 1 beta	Mus musculus	159-168
8029644-0	1994	IFN-gamma inhibits internalization of soluble aminated beta-1,3-D-glucan by macrophages and thereby down-regulates the glucan induced release of TNF-alpha and IL-1 beta.	Glucans	66-72	interleukin 1 beta	Mus musculus	159-168
8003032-2	1994	TNF alpha, IL-1 beta, and LPS caused a dose- and time-dependent increase of nitrite (NO2-), the stable metabolite of nitric oxide (NO), in conditioned media over 48 hours, while IFN gamma had a minimal effect.	Nitrites	76-83	interleukin 1 beta	Mus musculus	11-20
8003032-2	1994	TNF alpha, IL-1 beta, and LPS caused a dose- and time-dependent increase of nitrite (NO2-), the stable metabolite of nitric oxide (NO), in conditioned media over 48 hours, while IFN gamma had a minimal effect.	Nitrogen Dioxide	85-88	interleukin 1 beta	Mus musculus	11-20
8003032-2	1994	TNF alpha, IL-1 beta, and LPS caused a dose- and time-dependent increase of nitrite (NO2-), the stable metabolite of nitric oxide (NO), in conditioned media over 48 hours, while IFN gamma had a minimal effect.	Nitric Oxide	117-129	interleukin 1 beta	Mus musculus	11-20
8195155-0	1994	Interleukin-1 beta maturation and release in response to ATP and nigericin.	Adenosine Triphosphate	57-60	interleukin 1 beta	Mus musculus	0-18
8195155-0	1994	Interleukin-1 beta maturation and release in response to ATP and nigericin.	Nigericin	65-74	interleukin 1 beta	Mus musculus	0-18
8195155-3	1994	The potassium-proton ionophore nigericin and ATP are known to promote the maturation and release of IL-1 beta from LPS-stimulated cells.	Nigericin	31-40	interleukin 1 beta	Mus musculus	100-109
8195155-3	1994	The potassium-proton ionophore nigericin and ATP are known to promote the maturation and release of IL-1 beta from LPS-stimulated cells.	Adenosine Triphosphate	45-48	interleukin 1 beta	Mus musculus	100-109
8195155-5	1994	Like nigericin, the ionophores A204 and lasalocid induced the release and maturation of IL-1 beta.	Nigericin	5-14	interleukin 1 beta	Mus musculus	88-97
8195155-5	1994	Like nigericin, the ionophores A204 and lasalocid induced the release and maturation of IL-1 beta.	A 204	31-35	interleukin 1 beta	Mus musculus	88-97
8195155-5	1994	Like nigericin, the ionophores A204 and lasalocid induced the release and maturation of IL-1 beta.	Lasalocid	40-49	interleukin 1 beta	Mus musculus	88-97
8195155-9	1994	Post-translational maturation and release of IL-1 beta began immediately after ATP addition.	Adenosine Triphosphate	79-82	interleukin 1 beta	Mus musculus	45-54
8195155-10	1994	The majority of the 17-kDa mature IL-1 beta produced within the first 30 min of treatment was recovered extracellularly; in contrast, during this same time period the 35-kDa IL-1 beta precursor and the cytoplasmic marker enzyme lactate dehydrogenase and the lysosomal enzyme beta-N-acetylglucosaminidase remained cell-associated.	17-kda	20-26	interleukin 1 beta	Mus musculus	34-43
8195155-11	1994	ATP, therefore, promoted both the proteolytic maturation of IL-1 beta and the release of the biologically active species in the absence of cell lysis.	Adenosine Triphosphate	0-3	interleukin 1 beta	Mus musculus	60-69
8195155-13	1994	ADP was less active than ATP at initiating the post-translational maturation and release of IL-1 beta and AMP, GTP, and UTP were totally inactive, ATP, nigericin, A204, and lasalocid promoted a rapid and complete loss of the potassium analog 86Rb+ from cells that were preloaded with this cation; valinomycin-treated cells released only a portion of the radiolabeled cation.	Adenosine Diphosphate	0-3	interleukin 1 beta	Mus musculus	92-101
8195155-13	1994	ADP was less active than ATP at initiating the post-translational maturation and release of IL-1 beta and AMP, GTP, and UTP were totally inactive, ATP, nigericin, A204, and lasalocid promoted a rapid and complete loss of the potassium analog 86Rb+ from cells that were preloaded with this cation; valinomycin-treated cells released only a portion of the radiolabeled cation.	Adenosine Triphosphate	25-28	interleukin 1 beta	Mus musculus	92-101
8195155-13	1994	ADP was less active than ATP at initiating the post-translational maturation and release of IL-1 beta and AMP, GTP, and UTP were totally inactive, ATP, nigericin, A204, and lasalocid promoted a rapid and complete loss of the potassium analog 86Rb+ from cells that were preloaded with this cation; valinomycin-treated cells released only a portion of the radiolabeled cation.	Nigericin	152-161	interleukin 1 beta	Mus musculus	92-101
8195155-13	1994	ADP was less active than ATP at initiating the post-translational maturation and release of IL-1 beta and AMP, GTP, and UTP were totally inactive, ATP, nigericin, A204, and lasalocid promoted a rapid and complete loss of the potassium analog 86Rb+ from cells that were preloaded with this cation; valinomycin-treated cells released only a portion of the radiolabeled cation.	A 204	163-167	interleukin 1 beta	Mus musculus	92-101
8195155-13	1994	ADP was less active than ATP at initiating the post-translational maturation and release of IL-1 beta and AMP, GTP, and UTP were totally inactive, ATP, nigericin, A204, and lasalocid promoted a rapid and complete loss of the potassium analog 86Rb+ from cells that were preloaded with this cation; valinomycin-treated cells released only a portion of the radiolabeled cation.	Lasalocid	173-182	interleukin 1 beta	Mus musculus	92-101
8195155-13	1994	ADP was less active than ATP at initiating the post-translational maturation and release of IL-1 beta and AMP, GTP, and UTP were totally inactive, ATP, nigericin, A204, and lasalocid promoted a rapid and complete loss of the potassium analog 86Rb+ from cells that were preloaded with this cation; valinomycin-treated cells released only a portion of the radiolabeled cation.	Potassium	225-234	interleukin 1 beta	Mus musculus	92-101
8195155-13	1994	ADP was less active than ATP at initiating the post-translational maturation and release of IL-1 beta and AMP, GTP, and UTP were totally inactive, ATP, nigericin, A204, and lasalocid promoted a rapid and complete loss of the potassium analog 86Rb+ from cells that were preloaded with this cation; valinomycin-treated cells released only a portion of the radiolabeled cation.	Rubidium-86	242-247	interleukin 1 beta	Mus musculus	92-101
8195155-13	1994	ADP was less active than ATP at initiating the post-translational maturation and release of IL-1 beta and AMP, GTP, and UTP were totally inactive, ATP, nigericin, A204, and lasalocid promoted a rapid and complete loss of the potassium analog 86Rb+ from cells that were preloaded with this cation; valinomycin-treated cells released only a portion of the radiolabeled cation.	Valinomycin	297-308	interleukin 1 beta	Mus musculus	92-101
8195155-14	1994	Agents that promoted the maturation and release of IL-1 beta from LPS-stimulated macrophages, therefore, shared an ability to mobilize intracellular potassium.	Potassium	149-158	interleukin 1 beta	Mus musculus	51-60
8195155-16	1994	These data suggest that ATP and nigericin induce a net decrease in intracellular levels of K+ which is necessary for activation of the post-translational maturation of IL-1 beta.	Adenosine Triphosphate	24-27	interleukin 1 beta	Mus musculus	168-177
8195155-16	1994	These data suggest that ATP and nigericin induce a net decrease in intracellular levels of K+ which is necessary for activation of the post-translational maturation of IL-1 beta.	Nigericin	32-41	interleukin 1 beta	Mus musculus	168-177
8048000-0	1994	Enhanced survival from cecal ligation and puncture with pentoxifylline is associated with altered neutrophil trafficking and reduced interleukin-1 beta expression but not inhibition of tumor necrosis factor synthesis.	Pentoxifylline	56-70	interleukin 1 beta	Mus musculus	133-151
8048000-6	1994	Pentoxifylline reduced IL-1 beta mRNA expression in lung and peritoneal macrophages but not TNF mRNA or immunoreactive TNF in the serum.	Pentoxifylline	0-14	interleukin 1 beta	Mus musculus	23-32
8048000-10	1994	Pentoxifylline treatment reduced lung neutrophil sequestration and IL-1 beta mRNA levels and increased cell recruitment in the peritoneum.	Pentoxifylline	0-14	interleukin 1 beta	Mus musculus	67-76
7948748-0	1994	TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide.	Nitric Oxide	124-136	interleukin 1 beta	Mus musculus	62-71
7948748-4	1994	In parallel with NO production, IL-1 beta+IFN-gamma+TNF-alpha impaired islet function, as judged by decreased islet DNA and insulin content, decreased glucose metabolism and decreased glucose-induced insulin release.	Glucose	151-158	interleukin 1 beta	Mus musculus	32-51
9397943-13	1994	IL-1beta alone in concentrations of 0.1, 1 and 10 ng/ml inhibited testosterone formation by 45%, 62% and 91%, respectively, in the presence of TNF-alpha (10 ng/ml), IL-1beta in a concentration as low as 0.1 ng/ml completely blocked hCG-induced testosterone formation.	Testosterone	244-256	interleukin 1 beta	Mus musculus	0-8
9397943-13	1994	IL-1beta alone in concentrations of 0.1, 1 and 10 ng/ml inhibited testosterone formation by 45%, 62% and 91%, respectively, in the presence of TNF-alpha (10 ng/ml), IL-1beta in a concentration as low as 0.1 ng/ml completely blocked hCG-induced testosterone formation.	Testosterone	244-256	interleukin 1 beta	Mus musculus	165-173
7518332-1	1994	Cytokine-specific alterations of monoamine activity were evident in the hypothalamus, hippocampus and prefrontal cortex 2 h following peripheral administration of recombinant interleukin (IL)-1 beta, IL-2 and IL-6 (200 ng, i.p.)	monoamine	33-42	interleukin 1 beta	Mus musculus	175-198
7521274-5	1994	Both CsA and FK506 (at 1 mumol/L) significantly inhibited nitrite production induced by recombinant murine interleukin-1 beta (rIL-1 beta).	Nitrites	58-65	interleukin 1 beta	Mus musculus	107-125
8168150-5	1994	Expression of cytokine mRNAs including TNF-alpha, IL-1 beta, IL-6, and GM-CSF was also enhanced by the treatment with DT-5461a.	DT 5461	118-126	interleukin 1 beta	Mus musculus	50-59
7509602-3	1994	Stimulation with cytomix, a combination of interleukin-1 beta, tumor necrosis factor-alpha, and interferon-gamma, elevated nitrite levels by 873% in the culture supernatants and enhanced the conversion of arginine to citrulline by 273% at 24 h. An increased number of cells stained for iNOS and an increase in iNOS mRNA was also observed.	Arginine	205-213	interleukin 1 beta	Mus musculus	43-90
7521274-5	1994	Both CsA and FK506 (at 1 mumol/L) significantly inhibited nitrite production induced by recombinant murine interleukin-1 beta (rIL-1 beta).	Cyclosporine	5-8	interleukin 1 beta	Mus musculus	107-125
7521274-5	1994	Both CsA and FK506 (at 1 mumol/L) significantly inhibited nitrite production induced by recombinant murine interleukin-1 beta (rIL-1 beta).	Tacrolimus	13-18	interleukin 1 beta	Mus musculus	107-125
7509602-3	1994	Stimulation with cytomix, a combination of interleukin-1 beta, tumor necrosis factor-alpha, and interferon-gamma, elevated nitrite levels by 873% in the culture supernatants and enhanced the conversion of arginine to citrulline by 273% at 24 h. An increased number of cells stained for iNOS and an increase in iNOS mRNA was also observed.	cytomix	17-24	interleukin 1 beta	Mus musculus	43-90
7509602-3	1994	Stimulation with cytomix, a combination of interleukin-1 beta, tumor necrosis factor-alpha, and interferon-gamma, elevated nitrite levels by 873% in the culture supernatants and enhanced the conversion of arginine to citrulline by 273% at 24 h. An increased number of cells stained for iNOS and an increase in iNOS mRNA was also observed.	Nitrites	123-130	interleukin 1 beta	Mus musculus	43-90
8186192-9	1994	THP and DHA markedly decreased the levels of TNF-alpha and IL-1 beta in the circulation of mice following LPS injection.	Tetrahydropapaveroline	0-3	interleukin 1 beta	Mus musculus	59-68
8186192-9	1994	THP and DHA markedly decreased the levels of TNF-alpha and IL-1 beta in the circulation of mice following LPS injection.	Apomorphine	8-11	interleukin 1 beta	Mus musculus	59-68
7509602-3	1994	Stimulation with cytomix, a combination of interleukin-1 beta, tumor necrosis factor-alpha, and interferon-gamma, elevated nitrite levels by 873% in the culture supernatants and enhanced the conversion of arginine to citrulline by 273% at 24 h. An increased number of cells stained for iNOS and an increase in iNOS mRNA was also observed.	Citrulline	217-227	interleukin 1 beta	Mus musculus	43-90
7901310-1	1993	Taxol is a potent, microtubule-stabilizing, antineoplastic drug that induces interleukin-1-beta (IL-1-beta) and tumor necrosis factor-alpha (TNF-alpha) release by thioglycolate-elicited mouse peritoneal macrophages.	Paclitaxel	0-5	interleukin 1 beta	Mus musculus	77-95
7512249-0	1993	Interferon-gamma and interleukin-1 beta induce nitric oxide formation from primary mouse astrocytes.	Nitric Oxide	47-59	interleukin 1 beta	Mus musculus	21-39
7512249-2	1993	We demonstrate by immunoprecipitation and nitrite formation that interleukin-1 beta (IL1 beta) plus interferon-gamma (INF gamma) induce the expression of nitric oxide synthase in primary cultures of murine cortical astrocytes.	Nitrites	42-49	interleukin 1 beta	Mus musculus	65-83
7512249-2	1993	We demonstrate by immunoprecipitation and nitrite formation that interleukin-1 beta (IL1 beta) plus interferon-gamma (INF gamma) induce the expression of nitric oxide synthase in primary cultures of murine cortical astrocytes.	Nitrites	42-49	interleukin 1 beta	Mus musculus	85-93
8399089-11	1993	Interestingly, we observed a progressive increase of the LPS-induced IL-1 beta gene expression and secretion among macrophages harvested from mice receiving the dietary supplement of saturated fatty acids.	Fatty Acids	183-204	interleukin 1 beta	Mus musculus	69-78
7901310-1	1993	Taxol is a potent, microtubule-stabilizing, antineoplastic drug that induces interleukin-1-beta (IL-1-beta) and tumor necrosis factor-alpha (TNF-alpha) release by thioglycolate-elicited mouse peritoneal macrophages.	Paclitaxel	0-5	interleukin 1 beta	Mus musculus	97-106
7901310-1	1993	Taxol is a potent, microtubule-stabilizing, antineoplastic drug that induces interleukin-1-beta (IL-1-beta) and tumor necrosis factor-alpha (TNF-alpha) release by thioglycolate-elicited mouse peritoneal macrophages.	Thioglycolates	163-176	interleukin 1 beta	Mus musculus	77-95
7901310-1	1993	Taxol is a potent, microtubule-stabilizing, antineoplastic drug that induces interleukin-1-beta (IL-1-beta) and tumor necrosis factor-alpha (TNF-alpha) release by thioglycolate-elicited mouse peritoneal macrophages.	Thioglycolates	163-176	interleukin 1 beta	Mus musculus	97-106
8368299-4	1993	The impaired responses to mIL-1 beta in the aged mice were normalized by either injection of the glucocorticoid receptor antagonist RU-38486 or by injection of an antiserum to lipocortin-1 or its purified immunoglobulin G fraction.	Mifepristone	132-140	interleukin 1 beta	Mus musculus	26-36
7506289-0	1993	Interleukin-1 beta induces nitric oxide production by a mouse pituitary tumour cell line (AtT20/D16).	Nitric Oxide	27-39	interleukin 1 beta	Mus musculus	0-18
7506289-2	1993	Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3-(NOx) in a time-dependent manner and both NOx and cyclic GMP formation were stimulated in a dose-dependent manner by IL-1 beta.	Nitrogen Dioxide	56-61	interleukin 1 beta	Mus musculus	0-18
7506289-2	1993	Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3-(NOx) in a time-dependent manner and both NOx and cyclic GMP formation were stimulated in a dose-dependent manner by IL-1 beta.	Nitrogen Dioxide	56-61	interleukin 1 beta	Mus musculus	20-29
7506289-2	1993	Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3-(NOx) in a time-dependent manner and both NOx and cyclic GMP formation were stimulated in a dose-dependent manner by IL-1 beta.	Nitrogen Dioxide	56-61	interleukin 1 beta	Mus musculus	182-191
7506289-2	1993	Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3-(NOx) in a time-dependent manner and both NOx and cyclic GMP formation were stimulated in a dose-dependent manner by IL-1 beta.	punky blue	61-66	interleukin 1 beta	Mus musculus	0-18
7506289-2	1993	Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3-(NOx) in a time-dependent manner and both NOx and cyclic GMP formation were stimulated in a dose-dependent manner by IL-1 beta.	punky blue	61-66	interleukin 1 beta	Mus musculus	20-29
7506289-2	1993	Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3-(NOx) in a time-dependent manner and both NOx and cyclic GMP formation were stimulated in a dose-dependent manner by IL-1 beta.	punky blue	61-66	interleukin 1 beta	Mus musculus	182-191
7506289-2	1993	Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3-(NOx) in a time-dependent manner and both NOx and cyclic GMP formation were stimulated in a dose-dependent manner by IL-1 beta.	nicotine 1-N-oxide	66-69	interleukin 1 beta	Mus musculus	0-18
7506289-2	1993	Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3-(NOx) in a time-dependent manner and both NOx and cyclic GMP formation were stimulated in a dose-dependent manner by IL-1 beta.	nicotine 1-N-oxide	66-69	interleukin 1 beta	Mus musculus	20-29
7506289-2	1993	Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3-(NOx) in a time-dependent manner and both NOx and cyclic GMP formation were stimulated in a dose-dependent manner by IL-1 beta.	nicotine 1-N-oxide	107-110	interleukin 1 beta	Mus musculus	0-18
7506289-2	1993	Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3-(NOx) in a time-dependent manner and both NOx and cyclic GMP formation were stimulated in a dose-dependent manner by IL-1 beta.	nicotine 1-N-oxide	107-110	interleukin 1 beta	Mus musculus	182-191
7506289-2	1993	Interleukin-1 beta (IL-1 beta) stimulated production of NO2-/NO3-(NOx) in a time-dependent manner and both NOx and cyclic GMP formation were stimulated in a dose-dependent manner by IL-1 beta.	Cyclic GMP	115-125	interleukin 1 beta	Mus musculus	182-191
7506289-3	1993	IL-1 beta-induced NOx production and intracellular cyclic GMP formation were similarly blocked by an NO synthase inhibitor, NG-monomethyl-L-arginine (LNMMA), whose effect was reversed by L-arginine, but not by D-arginine.	nicotine 1-N-oxide	18-21	interleukin 1 beta	Mus musculus	0-9
7506289-3	1993	IL-1 beta-induced NOx production and intracellular cyclic GMP formation were similarly blocked by an NO synthase inhibitor, NG-monomethyl-L-arginine (LNMMA), whose effect was reversed by L-arginine, but not by D-arginine.	omega-N-Methylarginine	124-148	interleukin 1 beta	Mus musculus	0-9
7506289-3	1993	IL-1 beta-induced NOx production and intracellular cyclic GMP formation were similarly blocked by an NO synthase inhibitor, NG-monomethyl-L-arginine (LNMMA), whose effect was reversed by L-arginine, but not by D-arginine.	omega-N-Methylarginine	150-155	interleukin 1 beta	Mus musculus	0-9
7506289-3	1993	IL-1 beta-induced NOx production and intracellular cyclic GMP formation were similarly blocked by an NO synthase inhibitor, NG-monomethyl-L-arginine (LNMMA), whose effect was reversed by L-arginine, but not by D-arginine.	Arginine	138-148	interleukin 1 beta	Mus musculus	0-9
7506289-3	1993	IL-1 beta-induced NOx production and intracellular cyclic GMP formation were similarly blocked by an NO synthase inhibitor, NG-monomethyl-L-arginine (LNMMA), whose effect was reversed by L-arginine, but not by D-arginine.	D-Arginine	210-220	interleukin 1 beta	Mus musculus	0-9
7506289-4	1993	Dexamethasone inhibited IL-1 beta-induced NOx production in a dose-dependent manner.	Dexamethasone	0-13	interleukin 1 beta	Mus musculus	24-33
7506289-4	1993	Dexamethasone inhibited IL-1 beta-induced NOx production in a dose-dependent manner.	nicotine 1-N-oxide	42-45	interleukin 1 beta	Mus musculus	24-33
8368299-6	1993	Resting plasma corticosterone concentrations were significantly elevated in the aged and adult mice, whereas injection of mIL-1 beta significantly raised plasma corticosterone concentrations in all animals.	Corticosterone	161-175	interleukin 1 beta	Mus musculus	122-132
8354640-10	1993	Treatment of rats with ebselen inhibited by 33-65% PMNL migration to the mTNF alpha inflamed joints, and to dermal inflammation induced by zymosan activated serum (ZAS; containing C5adesArg), endotoxin (LPS), mIL-1 beta and mTNF alpha.	ebselen	23-30	interleukin 1 beta	Mus musculus	209-234
8260598-5	1993	Additionally, culture in the presence of actinomycin D (Act D) showed differential stabilities of the IL-1 alpha and IL-1 beta RNAs in these cells.	Dactinomycin	41-54	interleukin 1 beta	Mus musculus	117-126
8477669-2	1993	To determine the role of cytokines in mediating these changes, we studied the effects of endotoxin (LPS), tumor necrosis factor-alpha (TNF) and interleukin-1 beta (IL-1) on cholesterol and TG metabolism in C57Bl/6 (LPS-sensitive) mice and in C3H/HeJ (LPS-resistant) mice whose macrophages do not produce TNF and IL-1 in response to LPS.	Cholesterol	173-184	interleukin 1 beta	Mus musculus	144-162
8514850-3	1993	In murine bone marrow-derived macrophages, we found that soluble hyaluronic acid stimulated IL-1 beta, TNF alpha, and insulin-like growth factor-1 (IGF-1) mRNA transcript expression as well as IGF-1 protein synthesis.	Hyaluronic Acid	65-80	interleukin 1 beta	Mus musculus	92-101
8514850-4	1993	Monoclonal antibodies to the hyaluronic acid receptor CD44 blocked the effects of hyaluronic acid on IL-1 beta, TNF alpha, and IGF-1 expression.	Hyaluronic Acid	29-44	interleukin 1 beta	Mus musculus	101-110
8365826-5	1993	TA-383 inhibited the production of IL-6 by murine synovial fibroblasts stimulated with recombinant interleukin 1 (IL-1) beta in a dose-dependent manner (0.1-10 microM).	2-(4-chlorophenyl)-4,5-diphenyl-2-imidazoline hydrochloride	0-6	interleukin 1 beta	Mus musculus	114-124
8213352-6	1993	The effects of three anti-inflammatory or immunosuppressive drugs, prednisolone, indomethacin and cyclosporin A, on IL-1 beta and PGE2 production in zymosan and Bordetella-pertussis-vaccine (BPV)-challenged tissue chambers were also examined.	Prednisolone	67-79	interleukin 1 beta	Mus musculus	116-125
8384577-6	1993	Prostaglandin F2 alpha level in the supernatant was significantly increased, whereas that of IL-1 beta was reduced after incubation with Lipiodol.	Ethiodized Oil	137-145	interleukin 1 beta	Mus musculus	93-102
8384577-7	1993	CONCLUSIONS: Lipiodol may elevate PGF2 alpha level and reduce IL-1 beta level in the peritoneal cavity, and this drug may increase the PR of ICR mice.	Ethiodized Oil	13-21	interleukin 1 beta	Mus musculus	62-71
7694632-7	1993	Analysis of (C57BL/6JxBALB/cBy)F1 hybrids, which are shown in this report to be sensitive to bleomycin-induced fibrosis, revealed a high IL-1 beta mRNA level, similar to that in the resistant parent.	Bleomycin	93-102	interleukin 1 beta	Mus musculus	137-146
8213352-6	1993	The effects of three anti-inflammatory or immunosuppressive drugs, prednisolone, indomethacin and cyclosporin A, on IL-1 beta and PGE2 production in zymosan and Bordetella-pertussis-vaccine (BPV)-challenged tissue chambers were also examined.	Indomethacin	81-93	interleukin 1 beta	Mus musculus	116-125
8213352-6	1993	The effects of three anti-inflammatory or immunosuppressive drugs, prednisolone, indomethacin and cyclosporin A, on IL-1 beta and PGE2 production in zymosan and Bordetella-pertussis-vaccine (BPV)-challenged tissue chambers were also examined.	Cyclosporine	98-111	interleukin 1 beta	Mus musculus	116-125
8213352-7	1993	Oral treatment with prednisolone and cyclosporin A of zymosan-challenged animals showed a dose-dependent reduction of IL-1 beta concentrations, but no effect of indomethacin.	Prednisolone	20-32	interleukin 1 beta	Mus musculus	118-127
8213352-7	1993	Oral treatment with prednisolone and cyclosporin A of zymosan-challenged animals showed a dose-dependent reduction of IL-1 beta concentrations, but no effect of indomethacin.	Cyclosporine	37-50	interleukin 1 beta	Mus musculus	118-127
8213352-7	1993	Oral treatment with prednisolone and cyclosporin A of zymosan-challenged animals showed a dose-dependent reduction of IL-1 beta concentrations, but no effect of indomethacin.	Zymosan	54-61	interleukin 1 beta	Mus musculus	118-127
8213352-9	1993	In drug-treated BPV-challenged animals, prednisolone and cyclosporin A also showed a dose-dependent reduction of IL-1 beta, while indomethacin was again ineffective.	bromopyruvate	16-19	interleukin 1 beta	Mus musculus	113-122
8213352-9	1993	In drug-treated BPV-challenged animals, prednisolone and cyclosporin A also showed a dose-dependent reduction of IL-1 beta, while indomethacin was again ineffective.	Prednisolone	40-52	interleukin 1 beta	Mus musculus	113-122
8213352-9	1993	In drug-treated BPV-challenged animals, prednisolone and cyclosporin A also showed a dose-dependent reduction of IL-1 beta, while indomethacin was again ineffective.	Cyclosporine	57-70	interleukin 1 beta	Mus musculus	113-122
8383862-3	1993	Dibutyryl cyclic AMP also caused a persistent expression of the IL-1 beta gene, although it differed from X rays in that it coincidentally induced expression of the c-fos gene, which was not induced by X rays.	Bucladesine	0-20	interleukin 1 beta	Mus musculus	64-73
8425189-0	1993	Combined interleukin 1 beta/interleukin 2 treatment in mice: synergistic myelostimulatory activity and protection against cyclophosphamide-induced myelosuppression.	Cyclophosphamide	122-138	interleukin 1 beta	Mus musculus	9-41
8446594-3	1993	Ac-Tyr-Val-Ala-Asp-amino-4-methyl coumarin, patterned after site 2 of human pIL-1 beta, is a fluorogenic substrate for mICE, while the tetrapeptide aldehyde Ac-Tyr-Val-Ala-Asp-CHO is a potent inhibitor (Ki = 3 nM) that prevents generation and release of mature IL-1 beta by PECs (IC50 = 7 microM).	ac-tyr-val-ala-asp-amino-4-methyl coumarin	0-42	interleukin 1 beta	Mus musculus	77-86
8425189-6	1993	Combined IL-1 beta/IL-2 treatment dampened the decrease and accelerated the recovery of myeloid cells after cyclophosphamide injection, whereas the single cytokine regimen was not effective.	Cyclophosphamide	108-124	interleukin 1 beta	Mus musculus	9-18
8437110-6	1993	In vitro addition of interleukin (IL)-6, IL-1 beta or interferon-gamma (0.5-50 U/ml) attenuated the suppression of the PFC response in cells from morphine-treated mice, whereas higher doses (100 U/ml) restored completely the PFC response to control levels.	Morphine	146-154	interleukin 1 beta	Mus musculus	41-50
8425476-7	1993	In time-course studies, significant stimulation of the conversion of androstenedione to estrogens by hIL-1 beta could be detected as early as after 4 h of treatment and persisted for at least 24 h. Human IL-1 alpha stimulated the conversion of androstenedione to estrogens to an extent similar to that of hIL-1 beta, whereas the effects of murine IL-1 beta on aromatase activity were inconsistent.	Androstenedione	69-84	interleukin 1 beta	Mus musculus	102-111
8425476-7	1993	In time-course studies, significant stimulation of the conversion of androstenedione to estrogens by hIL-1 beta could be detected as early as after 4 h of treatment and persisted for at least 24 h. Human IL-1 alpha stimulated the conversion of androstenedione to estrogens to an extent similar to that of hIL-1 beta, whereas the effects of murine IL-1 beta on aromatase activity were inconsistent.	Androstenedione	244-259	interleukin 1 beta	Mus musculus	102-111
8476228-6	1993	This study indicates that oligomeric ellagitannins, which consist of tellimagrandin I or II, casuarictin or their related structure units, have antitumor activity and induce IL-1 beta.	Hydrolyzable Tannins	37-50	interleukin 1 beta	Mus musculus	174-183
8424175-0	1993	Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta.	Sphingomyelins	18-31	interleukin 1 beta	Mus musculus	99-108
8424175-3	1993	In intact EL4 thymoma cells, IL-1 beta similarly stimulated a rapid decrease of sphingomyelin and an elevation of ceramide, and enhanced ceramide-activated protein kinase activity.	Sphingomyelins	80-93	interleukin 1 beta	Mus musculus	29-38
8424175-3	1993	In intact EL4 thymoma cells, IL-1 beta similarly stimulated a rapid decrease of sphingomyelin and an elevation of ceramide, and enhanced ceramide-activated protein kinase activity.	Ceramides	114-122	interleukin 1 beta	Mus musculus	29-38
8424175-6	1993	Thus, IL-1 beta signals through the sphingomyelin pathway.	Sphingomyelins	36-49	interleukin 1 beta	Mus musculus	6-15
8476228-6	1993	This study indicates that oligomeric ellagitannins, which consist of tellimagrandin I or II, casuarictin or their related structure units, have antitumor activity and induce IL-1 beta.	tellimagrandin I	69-85	interleukin 1 beta	Mus musculus	174-183
8476228-6	1993	This study indicates that oligomeric ellagitannins, which consist of tellimagrandin I or II, casuarictin or their related structure units, have antitumor activity and induce IL-1 beta.	casuarictin	93-104	interleukin 1 beta	Mus musculus	174-183
7685182-4	1993	The capacity to produce interleukin 1-beta and TNF-alpha of peritoneal macrophages and also that to produce IL-6 of spleen cells were significantly enhanced by the in vivo administration of rhG-CSF in CY-treated mice.	Cyclophosphamide	201-203	interleukin 1 beta	Mus musculus	24-42
8136460-2	1993	We have presently studied the effect of aminoguanidine (AG), which has recently been reported to inhibit generation of NO induced by the cytokine interleukin-1 beta.	pimagedine	40-54	interleukin 1 beta	Mus musculus	146-164
8418915-6	1993	Treatment of murine decidual explants with LPS, IL-1 beta, and TNF resulted in significant increases in the production of prostaglandin E2 (PGE2) and IL-6.	Dinoprostone	122-138	interleukin 1 beta	Mus musculus	48-57
8418915-6	1993	Treatment of murine decidual explants with LPS, IL-1 beta, and TNF resulted in significant increases in the production of prostaglandin E2 (PGE2) and IL-6.	Dinoprostone	140-144	interleukin 1 beta	Mus musculus	48-57
7912536-8	1993	Examination of cellular mRNA levels in LPS and Taxol-activated macrophages by Northern blot analysis revealed increased expression of Interleukin-1 beta, and tumor necrosis factor-alpha cytokine mRNAs.	Paclitaxel	47-52	interleukin 1 beta	Mus musculus	134-185
1451948-10	1992	Culture of islets obtained from NOD mice in the presence of the cytokine interleukin-1 beta induced a similar pattern of glucose metabolism as seen earlier in IgG or phosphate-buffered saline treated control NOD mice.	Glucose	121-128	interleukin 1 beta	Mus musculus	73-91
22217835-6	1992	LPS treatment resulted in a 47-fold increase in interleukin-1beta (IL-1beta) mRNA in TIMs.	tims	85-89	interleukin 1 beta	Mus musculus	48-65
22217835-6	1992	LPS treatment resulted in a 47-fold increase in interleukin-1beta (IL-1beta) mRNA in TIMs.	tims	85-89	interleukin 1 beta	Mus musculus	67-75
22217835-11	1992	In vitro, LPS treatment of TIMs resulted in marked induction of IL-1beta mRNA expression.	tims	27-31	interleukin 1 beta	Mus musculus	64-72
1431103-2	1992	Murine IL-1 beta is initially synthesized as an inactive 33-kDa pro-molecule that is activated by proteolytic cleavage between Asp-117 and Val-118 to generate the 17-kDa mature IL-1 beta protein.	Aspartic Acid	127-130	interleukin 1 beta	Mus musculus	7-16
1425428-10	1992	IL-1 beta also increased steady state levels of 7.5- and 0.9-kilobase IGF-I mRNA transcripts in total RNA extracted from cultured calvaria at 24 h. The cyclooxygenase inhibitor indomethacin (1 microM) inhibited IL-1 beta-induced prostaglandin E2 (PGE2) production and inhibited resorption and release of IGF-I from calvaria.	Indomethacin	177-189	interleukin 1 beta	Mus musculus	0-9
1425428-10	1992	IL-1 beta also increased steady state levels of 7.5- and 0.9-kilobase IGF-I mRNA transcripts in total RNA extracted from cultured calvaria at 24 h. The cyclooxygenase inhibitor indomethacin (1 microM) inhibited IL-1 beta-induced prostaglandin E2 (PGE2) production and inhibited resorption and release of IGF-I from calvaria.	Indomethacin	177-189	interleukin 1 beta	Mus musculus	211-220
1425428-10	1992	IL-1 beta also increased steady state levels of 7.5- and 0.9-kilobase IGF-I mRNA transcripts in total RNA extracted from cultured calvaria at 24 h. The cyclooxygenase inhibitor indomethacin (1 microM) inhibited IL-1 beta-induced prostaglandin E2 (PGE2) production and inhibited resorption and release of IGF-I from calvaria.	Dinoprostone	229-245	interleukin 1 beta	Mus musculus	0-9
1425428-10	1992	IL-1 beta also increased steady state levels of 7.5- and 0.9-kilobase IGF-I mRNA transcripts in total RNA extracted from cultured calvaria at 24 h. The cyclooxygenase inhibitor indomethacin (1 microM) inhibited IL-1 beta-induced prostaglandin E2 (PGE2) production and inhibited resorption and release of IGF-I from calvaria.	Dinoprostone	247-251	interleukin 1 beta	Mus musculus	0-9
7688612-1	1993	Human recombinant IL-1 beta injected intraperitoneally into CBA mice dose-dependently induced leukocytosis, stimulated phagocytosis and reduced tetrazolium nitroblue by peritoneal leukocytes, colony formation by bone marrow cells, enhanced Con A and IL-2-induced proliferation and IL-2 production in thymocytes and splenocytes.	Tetrazolium Salts	144-155	interleukin 1 beta	Mus musculus	18-27
7688612-2	1993	Recombinant IL-1 beta restored bone marrow cell proliferation reduced after 5-fluorouracil treatment and significantly increased the survival rates of lethally irradiated mice.	Fluorouracil	76-90	interleukin 1 beta	Mus musculus	12-21
1473014-4	1992	Administration of IRAP largely prevented the effects of IL-1 alpha or IL-1 beta on the elevation of plasma corticosterone and the concomitant increase in hypothalamic norepinephrine metabolism, but failed to alter the responses to LPS.	Corticosterone	107-121	interleukin 1 beta	Mus musculus	70-79
1473014-4	1992	Administration of IRAP largely prevented the effects of IL-1 alpha or IL-1 beta on the elevation of plasma corticosterone and the concomitant increase in hypothalamic norepinephrine metabolism, but failed to alter the responses to LPS.	Norepinephrine	167-181	interleukin 1 beta	Mus musculus	70-79
1431103-2	1992	Murine IL-1 beta is initially synthesized as an inactive 33-kDa pro-molecule that is activated by proteolytic cleavage between Asp-117 and Val-118 to generate the 17-kDa mature IL-1 beta protein.	Valine	139-142	interleukin 1 beta	Mus musculus	7-16
1431103-2	1992	Murine IL-1 beta is initially synthesized as an inactive 33-kDa pro-molecule that is activated by proteolytic cleavage between Asp-117 and Val-118 to generate the 17-kDa mature IL-1 beta protein.	Valine	139-142	interleukin 1 beta	Mus musculus	177-186
1425926-0	1992	Selective and differential binding of interleukin (IL)-1 alpha, IL-1 beta, IL-2 and IL-6 to glycosaminoglycans.	Glycosaminoglycans	92-110	interleukin 1 beta	Mus musculus	64-73
1425926-1	1992	The binding of interleukin (IL)-1 alpha, IL-1 beta, IL-2 and IL-6 to acidic polysaccharides was investigated by affinity chromatography of the recombinant, radioiodinated interleukins on columns of immobilized polysaccharide.	Polysaccharides	76-91	interleukin 1 beta	Mus musculus	41-50
1425926-1	1992	The binding of interleukin (IL)-1 alpha, IL-1 beta, IL-2 and IL-6 to acidic polysaccharides was investigated by affinity chromatography of the recombinant, radioiodinated interleukins on columns of immobilized polysaccharide.	Polysaccharides	76-90	interleukin 1 beta	Mus musculus	41-50
1425926-4	1992	IL-1 alpha and IL-1 beta showed differential binding, with only the latter binding to hyaluronic acid.	Hyaluronic Acid	86-101	interleukin 1 beta	Mus musculus	15-24
1451948-10	1992	Culture of islets obtained from NOD mice in the presence of the cytokine interleukin-1 beta induced a similar pattern of glucose metabolism as seen earlier in IgG or phosphate-buffered saline treated control NOD mice.	Phosphate-Buffered Saline	166-191	interleukin 1 beta	Mus musculus	73-91
1382293-2	1992	In BMMCs sensitized with IgE anti-trinitrophenyl, CsA inhibited trinitrophenylated bovine serum albumin-induced increases in mRNA for IL-1 beta, tumor necrosis factor alpha (TNF-alpha), and IL-6 in a dose-related manner (IC50 values of 4, 65, and 130 nM, respectively).	Cyclosporine	50-53	interleukin 1 beta	Mus musculus	134-143
1356126-4	1992	Toward this end, the ability of taxol to induce TNF-alpha mRNA and five other genes (IL-1 beta, IP-10, D3, D7, and D8) associated with LPS-activation of macrophages was examined by Northern blot analysis.	Paclitaxel	32-37	interleukin 1 beta	Mus musculus	85-94
1382293-6	1992	That CsA inhibited IL-1 beta mRNA accumulation in IgE-activated BMMCs with an IC50 similar to that for inhibition of calcineurin activity, whereas the IC50 values were approximately 20-fold higher for the inhibition of TNF-alpha and IL-6 mRNA, suggests that the induction of TNF-alpha and IL-6 is less dependent upon calcineurin activity than is the induction of IL-1 beta.	Cyclosporine	5-8	interleukin 1 beta	Mus musculus	19-28
1382293-6	1992	That CsA inhibited IL-1 beta mRNA accumulation in IgE-activated BMMCs with an IC50 similar to that for inhibition of calcineurin activity, whereas the IC50 values were approximately 20-fold higher for the inhibition of TNF-alpha and IL-6 mRNA, suggests that the induction of TNF-alpha and IL-6 is less dependent upon calcineurin activity than is the induction of IL-1 beta.	Cyclosporine	5-8	interleukin 1 beta	Mus musculus	363-372
1500719-0	1992	IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin.	Nigericin	93-102	interleukin 1 beta	Mus musculus	0-9
1382324-0	1992	Dimethylnitrosamine (DMN)-induced IL-1 beta, TNF-alpha, and IL-6 inflammatory cytokine expression.	Dimethylnitrosamine	0-19	interleukin 1 beta	Mus musculus	34-43
1382324-0	1992	Dimethylnitrosamine (DMN)-induced IL-1 beta, TNF-alpha, and IL-6 inflammatory cytokine expression.	Dimethylnitrosamine	21-24	interleukin 1 beta	Mus musculus	34-43
1382324-8	1992	IL-1 beta, IL-6, and TNF-alpha serum activities were observed within 2 hr of DMN exposure and returned to vehicle control levels by 3 days even though DMN exposure was maintained.	Dimethylnitrosamine	77-80	interleukin 1 beta	Mus musculus	0-9
1382324-10	1992	A rapid induction of IL-1 beta transcripts (within 1 hr) in both vehicle and DMN-treated animals was observed by solution hybridization.	Dimethylnitrosamine	77-80	interleukin 1 beta	Mus musculus	21-30
1382324-12	1992	These results demonstrated that DMN exposure in vivo induced: (1) the expression of serum-borne cytokine activities, and (2) IL-1 beta transcription in liver tissue.	Dimethylnitrosamine	32-35	interleukin 1 beta	Mus musculus	125-134
1500719-4	1992	The calcium ionophore A23187 and the detergent saponin caused complete release of nonprocessed 35-kDa pro-IL-1 beta and liberation into the extracellular medium of the cytoplasmic marker enzyme LDH and the lysosomal enzyme beta-N-acetylglucosaminidase.	Calcium	4-11	interleukin 1 beta	Mus musculus	106-115
1500719-4	1992	The calcium ionophore A23187 and the detergent saponin caused complete release of nonprocessed 35-kDa pro-IL-1 beta and liberation into the extracellular medium of the cytoplasmic marker enzyme LDH and the lysosomal enzyme beta-N-acetylglucosaminidase.	Calcimycin	22-28	interleukin 1 beta	Mus musculus	106-115
1500719-4	1992	The calcium ionophore A23187 and the detergent saponin caused complete release of nonprocessed 35-kDa pro-IL-1 beta and liberation into the extracellular medium of the cytoplasmic marker enzyme LDH and the lysosomal enzyme beta-N-acetylglucosaminidase.	Saponins	47-54	interleukin 1 beta	Mus musculus	106-115
1500719-6	1992	Importantly, incubation of the murine macrophages with the potassium/proton ionophore nigericin led to a quantitative conversion of pro-IL-1 beta to a 17-kDa species.	Nigericin	86-95	interleukin 1 beta	Mus musculus	136-145
1500719-7	1992	The N-terminus of this nigericin-derived product possessed the amino acid sequence expected for mature biologically active IL-1 beta.	Nigericin	23-32	interleukin 1 beta	Mus musculus	123-132
1500719-9	1992	Complete release of mature IL-1 beta required concentrations of nigericin in excess of 2 microM and a minimum of 10 min of treatment.	Nigericin	64-73	interleukin 1 beta	Mus musculus	27-36
1500719-10	1992	Mature 17-kDa IL-1 beta was observed within the nigericin-treated cells before their lysis.	Nigericin	48-57	interleukin 1 beta	Mus musculus	14-23
1500719-11	1992	Nigericin"s effect was not limited to mouse peritoneal macrophages, inasmuch as the ionophore also induced release and proteolytic maturation of IL-1 beta produced by LPS-stimulated human peripheral blood monocytes.	Nigericin	0-9	interleukin 1 beta	Mus musculus	145-154
1500719-12	1992	Treatment of macrophages with LPS and nigericin, therefore, results in a unique series of intracellular events that promote formation of mature 17-kDa IL-1 beta.	Nigericin	38-47	interleukin 1 beta	Mus musculus	151-160
1612727-4	1992	Inhibition was apparent in normal and D-galactosamine (GalN)-sensitized mice and occurred at the pretranslational level, as splenic TNF and interleukin-1 beta mRNAs were present in lower amounts in LPS-stimulated mice pretreated with Rs-DPLA.	Galactosamine	38-53	interleukin 1 beta	Mus musculus	140-158
1612727-4	1992	Inhibition was apparent in normal and D-galactosamine (GalN)-sensitized mice and occurred at the pretranslational level, as splenic TNF and interleukin-1 beta mRNAs were present in lower amounts in LPS-stimulated mice pretreated with Rs-DPLA.	Galactosamine	55-59	interleukin 1 beta	Mus musculus	140-158
1612727-4	1992	Inhibition was apparent in normal and D-galactosamine (GalN)-sensitized mice and occurred at the pretranslational level, as splenic TNF and interleukin-1 beta mRNAs were present in lower amounts in LPS-stimulated mice pretreated with Rs-DPLA.	Rs-DPLA	234-241	interleukin 1 beta	Mus musculus	140-158
1588038-9	1992	In vivo expression in the spleen of 10 cytokine genes was also examined, and mRNA encoding IL-1 beta and IL-6 were significantly elevated in splenocytes of anilide-treated mice.	Anilides	156-163	interleukin 1 beta	Mus musculus	91-100
1602402-10	1992	IL-1 alpha and IL-1 beta increased cerebral concentrations of MHPG, 5-HIAA and tryptophan, but not DOPAC.	Methoxyhydroxyphenylglycol	62-66	interleukin 1 beta	Mus musculus	15-24
1602402-10	1992	IL-1 alpha and IL-1 beta increased cerebral concentrations of MHPG, 5-HIAA and tryptophan, but not DOPAC.	Hydroxyindoleacetic Acid	68-74	interleukin 1 beta	Mus musculus	15-24
1602402-10	1992	IL-1 alpha and IL-1 beta increased cerebral concentrations of MHPG, 5-HIAA and tryptophan, but not DOPAC.	Tryptophan	79-89	interleukin 1 beta	Mus musculus	15-24
1535517-3	1992	The two test agents counteracted the initial stimulatory actions of IL-1 beta on both islet glucose-induced insulin release and glucose oxidation rates.	Glucose	92-99	interleukin 1 beta	Mus musculus	68-77
1374912-8	1992	In contrast, blocking interleukin 1 beta gene expression by antisense oligonucleotide treatment had no effect on proliferation.	Oligonucleotides	70-85	interleukin 1 beta	Mus musculus	22-40
1560050-3	1992	We report here that nanomolar concentrations of STAR strongly potentiated (20- to 30-fold) the production of IL-2 or IL-4, when EL 4-6.1 cells were induced by IL-1 alpha (or IL-1 beta) alone.	Staurosporine	48-52	interleukin 1 beta	Mus musculus	174-183
1596738-6	1992	Central IL-1 beta administration was also more potent than IP injection in inhibiting overnight food and water intake.	Water	105-110	interleukin 1 beta	Mus musculus	8-17
1596738-9	1992	This comparison suggests that the IL-1 beta stimulation of serum corticosterone and IL-6 and inhibition of food and water intake are events more centrally mediated than the IL-1 beta-induced hypoglycemia.	Corticosterone	65-79	interleukin 1 beta	Mus musculus	34-43
1731791-0	1992	Interleukin-1 beta induces nitric oxide production and inhibits the activity of aconitase without decreasing glucose oxidation rates in isolated mouse pancreatic islets.	Nitric Oxide	27-39	interleukin 1 beta	Mus musculus	0-18
1731791-1	1992	The aim of this investigation was to further characterize the process of interleukin-1 beta (IL-1 beta) induced nitric oxide production in isolated pancreatic islets.	Nitric Oxide	112-124	interleukin 1 beta	Mus musculus	73-91
1731791-1	1992	The aim of this investigation was to further characterize the process of interleukin-1 beta (IL-1 beta) induced nitric oxide production in isolated pancreatic islets.	Nitric Oxide	112-124	interleukin 1 beta	Mus musculus	93-102
1731791-2	1992	It was found that both IL-1 beta and nitroprusside increased islet nitrite production.	Nitrites	67-74	interleukin 1 beta	Mus musculus	23-32
1731791-6	1992	The islets responded to IL-1 beta with an increased nitrite production and a decreased activity of aconitase, whereas the islet glucose oxidation rates were not decreased.	Nitrites	52-59	interleukin 1 beta	Mus musculus	24-33
1577194-8	1992	Uterus from ovariectomized mice contained little or no cytokine activity, and systemic administration of estrogen or progesterone resulted in the induction of IL-1 alpha and IL-1 beta mRNA expression.	Progesterone	117-129	interleukin 1 beta	Mus musculus	174-183
1540091-5	1992	Burned mice that received either interleukin 1 beta or indomethacin alone demonstrated tumor necrosis factor and interleukin 6 production and survival intermediate between the interleukin 1 beta-indomethacin-treated group and the vehicle control group.	Indomethacin	55-67	interleukin 1 beta	Mus musculus	176-194
1540091-5	1992	Burned mice that received either interleukin 1 beta or indomethacin alone demonstrated tumor necrosis factor and interleukin 6 production and survival intermediate between the interleukin 1 beta-indomethacin-treated group and the vehicle control group.	Indomethacin	195-207	interleukin 1 beta	Mus musculus	33-51
1540091-5	1992	Burned mice that received either interleukin 1 beta or indomethacin alone demonstrated tumor necrosis factor and interleukin 6 production and survival intermediate between the interleukin 1 beta-indomethacin-treated group and the vehicle control group.	Indomethacin	195-207	interleukin 1 beta	Mus musculus	176-194
1729371-4	1992	Although the suppression of IL-1 beta mRNA accumulation by N-(6-amonohexyl)-5-chloro-1-napthalene-sulfonamide or bis-(o-amonophenoxy)ethane-N,N,N"N"-tetraacetic acid occurred even if the antagonist was added after LPS, the potentiation of IP-10 mRNA levels required the use of the agent before or along with the LPS stimulus.	n-(6-amonohexyl)-5-chloro-1-napthalene-sulfonamide	59-109	interleukin 1 beta	Mus musculus	28-37
1535517-4	1992	Furthermore, cycloheximide, an inhibitor of protein synthesis, could also prevent the early IL-1 beta-induced stimulation of insulin release.	Cycloheximide	13-26	interleukin 1 beta	Mus musculus	92-101
1535517-5	1992	When islets were exposed for 1 hr to IL-1 beta and studied after 12 hr, there was a 75% inhibition of glucose induced insulin release, a 50% decrease in glucose oxidation rates and a 30% decrease in (pro)insulin biosynthesis.	Glucose	102-109	interleukin 1 beta	Mus musculus	37-46
1535517-9	1992	Mouse islets exposed for 2 hr to IL-1 beta and studied after 12 hr presented a 50% decrease in the glucose-induced insulin release.	Glucose	99-106	interleukin 1 beta	Mus musculus	33-42
1814758-0	1991	Enhanced sensitivity to anorexia and consumption of drinking water induced by interleukin-1 beta in obese yellow mice.	Water	61-66	interleukin 1 beta	Mus musculus	78-96
1727430-2	1992	After in vitro activation by lipopolysaccharide acid (LPS), these macrophages hyperexpress IL-1 beta mRNA and hyperproduce IL-1 protein in comparison with +/+ controls.	lipopolysaccharide acid	29-52	interleukin 1 beta	Mus musculus	91-100
1727430-2	1992	After in vitro activation by lipopolysaccharide acid (LPS), these macrophages hyperexpress IL-1 beta mRNA and hyperproduce IL-1 protein in comparison with +/+ controls.	lps	54-57	interleukin 1 beta	Mus musculus	91-100
1727430-4	1992	The hyperexpression of IL-1 beta mRNA in sg/sg macrophages is present whatever the duration of LPS stimulation, even for periods as short as 15 min, although it reaches a maximum after 4 h of stimulation.	lps	95-98	interleukin 1 beta	Mus musculus	23-32
1796759-10	1991	GN also inhibited the resorption elicited by thyroxine (1 microM) and interleukin-1 beta (10 nM) but not by 1,25-dihydroxyvitamin D3 (30 pM).	gallium nitrate	0-2	interleukin 1 beta	Mus musculus	70-88
1916897-4	1991	The down-regulation of IL-1 beta by cycloheximide was not apparent for IL-1 alpha mRNA, which had a two- to three-fold increase in the LPS-stimulated cycloheximide-treated macrophages.	Cycloheximide	36-49	interleukin 1 beta	Mus musculus	23-32
1793052-3	1991	When Arg in position 4 of DuP118 was replaced by Glu (Glu-4), proteoglycan-synthesis-inhibitory activity was reduced to 20% and proteoglycan-degrading activity to 2% of that induced by native IL-1 beta.	Arginine	5-8	interleukin 1 beta	Mus musculus	192-201
1793052-3	1991	When Arg in position 4 of DuP118 was replaced by Glu (Glu-4), proteoglycan-synthesis-inhibitory activity was reduced to 20% and proteoglycan-degrading activity to 2% of that induced by native IL-1 beta.	dup118	26-32	interleukin 1 beta	Mus musculus	192-201
1793052-3	1991	When Arg in position 4 of DuP118 was replaced by Glu (Glu-4), proteoglycan-synthesis-inhibitory activity was reduced to 20% and proteoglycan-degrading activity to 2% of that induced by native IL-1 beta.	Glutamic Acid	49-52	interleukin 1 beta	Mus musculus	192-201
1793052-3	1991	When Arg in position 4 of DuP118 was replaced by Glu (Glu-4), proteoglycan-synthesis-inhibitory activity was reduced to 20% and proteoglycan-degrading activity to 2% of that induced by native IL-1 beta.	Glutamic Acid	54-57	interleukin 1 beta	Mus musculus	192-201
1916897-4	1991	The down-regulation of IL-1 beta by cycloheximide was not apparent for IL-1 alpha mRNA, which had a two- to three-fold increase in the LPS-stimulated cycloheximide-treated macrophages.	Cycloheximide	150-163	interleukin 1 beta	Mus musculus	23-32
1916897-6	1991	Cycloheximide-treated LPS-stimulated macrophages demonstrated a significant increase in transcriptional activity for TNF, but not IL-1 beta, by nuclear run-on transcription assays and an increase in the amount of the nuclear binding factor NFKB when compared to LPS controls.	Cycloheximide	0-13	interleukin 1 beta	Mus musculus	130-139
1916897-8	1991	Therefore, the differential expression of TNF and IL-1 beta mRNA in cycloheximide-treated macrophages involves both transcriptional and post-transcriptional regulatory mechanisms.	Cycloheximide	68-81	interleukin 1 beta	Mus musculus	50-59
1676876-0	1991	Influence of azelastine on IL-1 beta generation in vitro and IL-1 beta-induced effect in vivo.	azelastine	13-23	interleukin 1 beta	Mus musculus	27-36
1832112-3	1991	Brief exposure (1-2 h) of rat and mouse pancreatic islets to 10 ng/ml recombinant interleukin-1 beta induced an 70-80% inhibition of insulin response to glucose after 12 h. These effects were completely counteracted by co-incubation with 100 ng/ml interleukin-1 receptor antagonist protein.	Glucose	153-160	interleukin 1 beta	Mus musculus	82-100
1826703-0	1991	Formation of intrachain disulfide bonds gives rise to two different forms of the murine IL-1 beta precursor.	Disulfides	24-33	interleukin 1 beta	Mus musculus	88-97
1826703-11	1991	These data indicate that murine macrophages contain two populations of the IL-1 beta precursor, one of which can undergo a disulfide-mediated protein folding; they also suggest that oxidation of -SH groups may be critical for the proteolytic processing of the IL-1 beta precursor.	Disulfides	123-132	interleukin 1 beta	Mus musculus	75-84
1826365-7	1991	These results with IL-1ra K145D demonstrate the importance of the region surrounding the corresponding Asp-145 residue in IL-1 beta for triggering the biological response to IL-1.	Aspartic Acid	103-106	interleukin 1 beta	Mus musculus	122-131
2025252-1	1991	Interleukin-1 (IL-1) alpha and beta dose-dependently stimulated the release of 45Ca and the formation of prostaglandin E2 (PGE2) and PGI2 in cultured mouse calvarial bones, with IL-1 beta being the most potent agonist.	Dinoprostone	105-121	interleukin 1 beta	Mus musculus	178-187
2025252-1	1991	Interleukin-1 (IL-1) alpha and beta dose-dependently stimulated the release of 45Ca and the formation of prostaglandin E2 (PGE2) and PGI2 in cultured mouse calvarial bones, with IL-1 beta being the most potent agonist.	Dinoprostone	123-127	interleukin 1 beta	Mus musculus	178-187
2025252-1	1991	Interleukin-1 (IL-1) alpha and beta dose-dependently stimulated the release of 45Ca and the formation of prostaglandin E2 (PGE2) and PGI2 in cultured mouse calvarial bones, with IL-1 beta being the most potent agonist.	Epoprostenol	133-137	interleukin 1 beta	Mus musculus	178-187
2025252-2	1991	Bradykinin (BK; 10 nmol/l) synergistically potentiated the effect of IL-1 alpha (10 pg/ml) and IL-1 beta (5 pg/ml) both on 45Ca release and on biosynthesis of PGE2 and PGI2.	Dinoprostone	159-163	interleukin 1 beta	Mus musculus	95-104
2025252-2	1991	Bradykinin (BK; 10 nmol/l) synergistically potentiated the effect of IL-1 alpha (10 pg/ml) and IL-1 beta (5 pg/ml) both on 45Ca release and on biosynthesis of PGE2 and PGI2.	Epoprostenol	168-172	interleukin 1 beta	Mus musculus	95-104
1993481-0	1991	Reduction of biological activity of murine recombinant interleukin-1 beta by selective deamidation at asparagine-149.	Asparagine	102-112	interleukin 1 beta	Mus musculus	55-73
1993481-2	1991	Treatment with 0.1 M Tris, pH 8.5, at 37 degrees C for 35 h converted the pI 8.7 form to the pI 8.1 form by the selective deamidation of an asparagine residue (Asn149) in the mIL-1 beta molecule.	Tromethamine	21-25	interleukin 1 beta	Mus musculus	175-185
1993481-2	1991	Treatment with 0.1 M Tris, pH 8.5, at 37 degrees C for 35 h converted the pI 8.7 form to the pI 8.1 form by the selective deamidation of an asparagine residue (Asn149) in the mIL-1 beta molecule.	Asparagine	140-150	interleukin 1 beta	Mus musculus	175-185
1655098-4	1991	However, when the cells were incubated with PGE1 alone or with IL-1 beta, LTB4 or LTC4 and CaI A23187, these effects were not observed.	Alprostadil	44-48	interleukin 1 beta	Mus musculus	63-72
1655098-4	1991	However, when the cells were incubated with PGE1 alone or with IL-1 beta, LTB4 or LTC4 and CaI A23187, these effects were not observed.	Calcimycin	95-101	interleukin 1 beta	Mus musculus	63-72
1992764-12	1991	Pretreatment with 4 mg/kg dexamethasone significantly decreased Kupffer cell expression of TNF and IL-1 alpha (about 80% and 60% suppression, respectively) but had less effect on IL-1 beta expression (about 30% suppression).	Dexamethasone	26-39	interleukin 1 beta	Mus musculus	179-188
1676876-1	1991	The effects of the novel antiasthmatic/antiallergic compound azelastine on IL-1 beta were investigated in vitro and in vivo.	azelastine	61-71	interleukin 1 beta	Mus musculus	75-84
1991858-0	1991	Involvement of PGE synthesis in the effect of intermittent pressure and interleukin-1 beta on bone resorption.	Prostaglandins E	15-18	interleukin 1 beta	Mus musculus	72-90
1873493-6	1991	Treatment of mice with ibuprofen or with chlorpromazine, both known to counteract some of the toxic effects of IL-1 in vivo, could protect from IL-1 beta induced mortality.	Ibuprofen	23-32	interleukin 1 beta	Mus musculus	144-153
1873493-6	1991	Treatment of mice with ibuprofen or with chlorpromazine, both known to counteract some of the toxic effects of IL-1 in vivo, could protect from IL-1 beta induced mortality.	Chlorpromazine	41-55	interleukin 1 beta	Mus musculus	144-153
1684549-5	1991	At the same concentration, isoproterenol increases the accumulation of IL-1 alpha and IL-1 beta mRNAs.	Isoproterenol	27-40	interleukin 1 beta	Mus musculus	86-95
1991858-4	1991	IL-1 beta-treated cells showed significantly elevated levels of PGE, bone resorption, and OC-like cell formation, as compared with unstimulated cells.	Prostaglandins E	64-67	interleukin 1 beta	Mus musculus	0-9
2114361-6	1990	The addition of antibodies specific for murine interleukin-1 beta to cocultures of Kupffer cells and T lymphocytes eliminated the antigen-stimulated incorporation of [3H]thymidine, indicating a requirement for interleukin-1.	3h]thymidine	167-179	interleukin 1 beta	Mus musculus	47-65
1850645-1	1991	Interleukin 1 beta (IL-1 beta) plasmid DNA was isolated and purified with alkaline lysis method and equilibrium centrifugation in cesium chloride.	cesium chloride	130-145	interleukin 1 beta	Mus musculus	0-18
1850645-1	1991	Interleukin 1 beta (IL-1 beta) plasmid DNA was isolated and purified with alkaline lysis method and equilibrium centrifugation in cesium chloride.	cesium chloride	130-145	interleukin 1 beta	Mus musculus	20-29
1850645-2	1991	IL-1 beta plasmid RNA was cut by restriction endonucleases EcoRI and XbaI, and after that it was 1 loaded in 0.75% low-melting-temperature agarose and underwent electrophoresis.	Sepharose	139-146	interleukin 1 beta	Mus musculus	0-9
2172382-5	1990	PGE2 and dBcAMP not only potentiated LPS-induced IL-1 beta mRNA levels but were also able to stimulate modest accumulation of IL-1 beta mRNA in the absence of LPS.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	126-135
2172382-5	1990	PGE2 and dBcAMP not only potentiated LPS-induced IL-1 beta mRNA levels but were also able to stimulate modest accumulation of IL-1 beta mRNA in the absence of LPS.	Bucladesine	9-15	interleukin 1 beta	Mus musculus	49-58
2172382-5	1990	PGE2 and dBcAMP not only potentiated LPS-induced IL-1 beta mRNA levels but were also able to stimulate modest accumulation of IL-1 beta mRNA in the absence of LPS.	Bucladesine	9-15	interleukin 1 beta	Mus musculus	126-135
1832187-3	1991	We have tried to map the domain of IL-1 beta by assessing the receptor interaction of synthetic octapeptide acid amides representing overlapping segments of the IL-1 beta primary sequence.	octapeptide acid amides	96-119	interleukin 1 beta	Mus musculus	35-44
2265245-5	1990	The incorporation of 75Se-selenomethionine into circulating platelets as a measure of platelet production was about 2.3 times higher in IL-1 beta-treated mice than in control mice.	75se-selenomethionine	21-42	interleukin 1 beta	Mus musculus	136-145
2172382-0	1990	cAMP differentially regulates expression of mRNA encoding IL-1 alpha and IL-1 beta in murine peritoneal macrophages.	Cyclic AMP	0-4	interleukin 1 beta	Mus musculus	73-82
2172382-4	1990	This effect was due to elevation of intracellular cAMP because other agents known to elevate cAMP levels (e.g., cholera toxin, forskolin, 1-isomethyl-3-isobutylxanthine) had the same selective effect on IL-1 beta mRNA levels.	Cyclic AMP	50-54	interleukin 1 beta	Mus musculus	203-212
2172382-4	1990	This effect was due to elevation of intracellular cAMP because other agents known to elevate cAMP levels (e.g., cholera toxin, forskolin, 1-isomethyl-3-isobutylxanthine) had the same selective effect on IL-1 beta mRNA levels.	Cyclic AMP	93-97	interleukin 1 beta	Mus musculus	203-212
2172382-4	1990	This effect was due to elevation of intracellular cAMP because other agents known to elevate cAMP levels (e.g., cholera toxin, forskolin, 1-isomethyl-3-isobutylxanthine) had the same selective effect on IL-1 beta mRNA levels.	1-isomethyl-3-isobutylxanthine	138-168	interleukin 1 beta	Mus musculus	203-212
2172382-5	1990	PGE2 and dBcAMP not only potentiated LPS-induced IL-1 beta mRNA levels but were also able to stimulate modest accumulation of IL-1 beta mRNA in the absence of LPS.	Dinoprostone	0-4	interleukin 1 beta	Mus musculus	49-58
1698759-0	1990	Modulation of the proliferative response of murine thymocytes stimulated by IL-1, and enhancement of IL-1 beta secretion from mononuclear phagocytes by tetracyclines.	Tetracyclines	152-165	interleukin 1 beta	Mus musculus	101-110
1698759-5	1990	LPS-stimulated monocytes secreted significantly more IL-1 beta in the presence of minocycline (P less than 0.01, 2-way analysis of variance).	Minocycline	82-93	interleukin 1 beta	Mus musculus	53-62
1698759-7	1990	Loss of viability could only be associated with enhanced IL-1 beta release by monocytes with 50 mg/l minocycline.	Minocycline	101-112	interleukin 1 beta	Mus musculus	57-66
2166677-3	1990	This effect of IL-1 beta was blocked by concurrent application of 100 nM Lys-D-Pro-Thr, a tripeptide analogue of IL-1 beta.	tripeptide K-26	90-100	interleukin 1 beta	Mus musculus	15-24
1698759-8	1990	Although tetracycline enhanced IL-1 beta secretion in four of the five replicate experiments, this did not prove significant owing to the large error variance between individual monocyte cultures.	Tetracycline	9-21	interleukin 1 beta	Mus musculus	31-40
1693530-9	1990	SDS-PAGE of the immunoprecipitates showed radioactive bands corresponding to the expected Mr resulting from complex formation between 125I-IL-1 beta and these two proteins.	Sodium Dodecyl Sulfate	0-3	interleukin 1 beta	Mus musculus	139-148
1693530-10	1990	Treatment of purified plasma alpha 2M and C3 with trypsin or activation with methylamine, which causes cleavage of the internal thiol ester and the appearance of free thiol groups in these proteins, mediated binding of 125I-IL-1 beta to alpha 2M and C3b.	methylamine	77-88	interleukin 1 beta	Mus musculus	224-233
1693530-10	1990	Treatment of purified plasma alpha 2M and C3 with trypsin or activation with methylamine, which causes cleavage of the internal thiol ester and the appearance of free thiol groups in these proteins, mediated binding of 125I-IL-1 beta to alpha 2M and C3b.	thiol ester	128-139	interleukin 1 beta	Mus musculus	224-233
1693530-10	1990	Treatment of purified plasma alpha 2M and C3 with trypsin or activation with methylamine, which causes cleavage of the internal thiol ester and the appearance of free thiol groups in these proteins, mediated binding of 125I-IL-1 beta to alpha 2M and C3b.	Sulfhydryl Compounds	128-133	interleukin 1 beta	Mus musculus	224-233
1693530-11	1990	The results suggest that cleavage of the internal thiol ester in C3 and alpha 2M makes these plasma proteins susceptible to binding of 125I-IL-1 beta and that free thiol groups do play a role in the formation of 125I-IL-1 beta plasma protein complexes.	Sulfhydryl Compounds	50-55	interleukin 1 beta	Mus musculus	140-149
2166677-3	1990	This effect of IL-1 beta was blocked by concurrent application of 100 nM Lys-D-Pro-Thr, a tripeptide analogue of IL-1 beta.	tripeptide K-26	90-100	interleukin 1 beta	Mus musculus	113-122
2129785-1	1990	Recombinant Interleukin-1 beta (rIL-1 beta) induced dose-dependent synthesis of PGE2 and activation of both cell-associated and soluble phospholipase A2 (PLA2) in cultured mouse peritoneal macrophages.	Dinoprostone	80-84	interleukin 1 beta	Mus musculus	12-30
1965393-9	1990	Periodontal fibroblasts responded to mechanical stress and interleukin-1 beta with significant elevations of PGE as early as 15 min, whereas the MC3T3-E1 cells required 2 h to produce significant elevations for mechanical stress and 15 min for interleukin-1 beta.	Prostaglandins E	109-112	interleukin 1 beta	Mus musculus	59-77
2168227-1	1990	Recombinant IL-1-beta, which is capable of stimulating the pituitary-adrenal axis to secrete corticosterone, was paired with environmental cues in either a taste aversion or odor conditioning procedure.	Corticosterone	93-107	interleukin 1 beta	Mus musculus	12-21
33821300-5	2021	RESULTS: DEX significantly inhibited LPS-induced increases in the lung weight/body weight ratio and lung wet/dry weight ratio, decreased inflammatory cell infiltration, and decreased the production of proinflammatory factors, such as interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor alpha (TNF-alpha)in the lungs.	Dexmedetomidine	9-12	interleukin 1 beta	Mus musculus	234-251
2104887-10	1990	Our results suggest that activated macrophages possess a novel processing independent, possibly calcium-dependent, mechanism that allows for the release of the precursor forms of IL-1 alpha and IL-1 beta.	Calcium	96-103	interleukin 1 beta	Mus musculus	194-203
33822229-12	2021	PTC923-treated mice showed a reduction in inflammatory mediators, especially IL-6 and IL-1b.	sepiapterin	0-6	interleukin 1 beta	Mus musculus	86-91
33812168-9	2021	In ApoE-/- mice, EPA reduced aortic expression of Il1b by 44% (p = 0.04) and Tnf by 49% (p = 0.04), with similar inverse correlations between EPA levels and both Il1b (r = -0.63, p = 0.009) and Tnf (r = -0.50, p = 0.04).	Eicosapentaenoic Acid	17-20	interleukin 1 beta	Mus musculus	50-54
33812168-9	2021	In ApoE-/- mice, EPA reduced aortic expression of Il1b by 44% (p = 0.04) and Tnf by 49% (p = 0.04), with similar inverse correlations between EPA levels and both Il1b (r = -0.63, p = 0.009) and Tnf (r = -0.50, p = 0.04).	Eicosapentaenoic Acid	17-20	interleukin 1 beta	Mus musculus	162-166
33761044-6	2021	Albicanol treatment also inhibited the secretion of inflammatory TNF-a and IL-1b.	albicanol	0-9	interleukin 1 beta	Mus musculus	75-80
31736980-5	2019	We also demonstrated that prophylactic oral administration of OLT1177 led to marked reduction (~2- to 3-fold) in the protein levels of IL-1beta and IL-18, as well as, IL-6 and TNFalpha, in the spinal cord of EAE mice.	nesosteine	62-69	interleukin 1 beta	Mus musculus	135-143
33809593-9	2021	Linolenic and linoleic acid significantly attenuated LPS-induced formation of reactive nitrogen species and interleukin-1 beta mRNA expression in J774A.1 cells.	linolenic	0-9	interleukin 1 beta	Mus musculus	108-126
33809593-9	2021	Linolenic and linoleic acid significantly attenuated LPS-induced formation of reactive nitrogen species and interleukin-1 beta mRNA expression in J774A.1 cells.	Linoleic Acid	14-27	interleukin 1 beta	Mus musculus	108-126
32796132-10	2020	The levels of the proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha and the enzyme MMP9 were reduced by JWH015.	JHW 015	130-136	interleukin 1 beta	Mus musculus	44-61
33031879-3	2021	An in vitro HaCaT inflammation model treated with dictamnine, which efficiently scavenged the reactive oxygen species (ROS) and mitochondrial ROS (mROS), and it reduced interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) expression, NLRP3 inflammasome activation, and NF-kappaB expression.	dictamnine	50-60	interleukin 1 beta	Mus musculus	169-186
32795892-7	2020	Meanwhile, CZ incubation markedly decreased the expression of pro-inflammatory cytokines including tumor necrosis factor alpha (TNF-alpha), interleukin-1beta (IL-1beta).	Chlorzoxazone	11-13	interleukin 1 beta	Mus musculus	140-157
30966861-5	2019	In addition, the small molecule kaempferol (Ka) protected mice against LPS- and SNCA-induced neurodegeneration by inhibiting NLRP3 inflammasome activation as evidenced by the fact that Ka reduced cleaved CASP1 expression and disrupted NLRP3-PYCARD-CASP1 complex assembly with concomitant decreased IL1B secretion.	kaempferol	32-42	interleukin 1 beta	Mus musculus	298-302
25676413-7	2015	Alcohol induced liver damage, elevated collagen content, and increased expression of nuclear factor kappa-light-chain-enhancer of activated B cells and inflammatory markers (tumour necrosis factor-alpha, interferon-gamma, interleukin-1beta, inducible nitric oxide synthase, cyclooxygenases-2, and transforming growth factor-beta).	Alcohols	0-7	interleukin 1 beta	Mus musculus	222-239
29576797-4	2018	We found that ALE inhibited IL-1beta secretion from NLRP3 inflammasome activated bone marrow derived macrophages but not that secreted by NLRC4 and AIM2 inflammasomes activation.	Epinephrine	14-17	interleukin 1 beta	Mus musculus	28-36
27784235-9	2016	RESULTS: Genistein suppressed the expressions of IL-1beta, IL-6 and TNF-alpha in the serum.	Genistein	9-18	interleukin 1 beta	Mus musculus	49-57
29752615-12	2018	Simvastatin reduced plasma levels of presepsin, IL-1beta, and IL-6.	Simvastatin	0-11	interleukin 1 beta	Mus musculus	48-56
24030525-7	2013	DSS-treated ClC-2 mice had increased claudin-2 expression, greater loss of occludin in the membrane, increased association of occludin with caveolin-1, and significantly increased tumor necrosis factor-alpha and interleukin-1beta messenger RNA.	dss	0-3	interleukin 1 beta	Mus musculus	212-229
34763041-8	2022	Expression of the inflammatory factors, such as tumor necrosis factor-alpha, interleukin-1beta (IL-1beta), IL-6, monocyte chemoattractant protein-1, and intercellular adhesion molecule 1, was significantly reduced in CBBP-treated cholestatic mice.	phosphon	217-221	interleukin 1 beta	Mus musculus	77-94
25431838-6	2015	Gain- and loss-of-function studies demonstrate that NEFA-induced CGI-58 suppression activates FOXO1 to augment IL-1beta transcription by dampening insulin signalling through induction of SOCS3 (suppressor of cytokine signalling 3) expression.	Fatty Acids, Nonesterified	52-56	interleukin 1 beta	Mus musculus	111-119
34409550-8	2022	Emodin also inhibited the expression of NLRP3 and reduced the levels of pro-inflammatory factors, including interleukin-1 beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha).	Emodin	0-6	interleukin 1 beta	Mus musculus	108-126
34736722-10	2022	Pregabalin and gabapentin increased HO-1, arginase-1, and endogenous opioid precursor preproenkephalin gene expression and decreased the expression of glial markers, interleukin-1beta, and inducible nitric oxide synthase.	Pregabalin	0-10	interleukin 1 beta	Mus musculus	166-183
34913079-12	2022	WLGO treatment also reduced the concentration and mRNA expression levels of proinflammatory cytokines, including interleukin-1beta, interleukin-6 and tumor necrosis factor alpha, in DSS-induced UC model mice and lipopolysaccharide-treated Caco-2 cells.	wlgo	0-4	interleukin 1 beta	Mus musculus	113-130
34601084-7	2022	RESULTS: FTF-EtOH suppressed CS-induced overproduction of inflammatory factors (e.g., tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta)), and upregulation of the content of intracellular MDA in the lung homogenate of mice.	Ethanol	13-17	interleukin 1 beta	Mus musculus	130-147
34601084-7	2022	RESULTS: FTF-EtOH suppressed CS-induced overproduction of inflammatory factors (e.g., tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta)), and upregulation of the content of intracellular MDA in the lung homogenate of mice.	Cesium	29-31	interleukin 1 beta	Mus musculus	130-147
34736722-10	2022	Pregabalin and gabapentin increased HO-1, arginase-1, and endogenous opioid precursor preproenkephalin gene expression and decreased the expression of glial markers, interleukin-1beta, and inducible nitric oxide synthase.	Gabapentin	15-25	interleukin 1 beta	Mus musculus	166-183
34551359-8	2022	QS-BD treatment promoted respiratory bursts and upregulated the expression of interleukin-1beta and tumour necrosis factor-alpha in the murine leukemic monocyte/macrophage cell line RAW264.7.	qs-bd	0-5	interleukin 1 beta	Mus musculus	78-95
34938384-8	2021	Finally, ceftriaxone treatment increased the expression of the tight junction proteins zona occludens-1(ZO-1) and occludin in the colon, decreased the expression of the inflammation-related proteins TLR4, MyD88, and NF-kappaB in the colon, and decreased the serum concentration of the proinflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumour necrosis factor-alpha (TNF-alpha).	Ceftriaxone	9-20	interleukin 1 beta	Mus musculus	311-328
34364883-9	2022	Gene expression analysis identified upregulation of Mxa, Il1b, Tnfa, Il6, Il12, Il23, Il17 and Ifng in TG>WT>KO following IMQ treatment.	Imiquimod	122-125	interleukin 1 beta	Mus musculus	57-61
34951571-11	2022	Moreover, treatment with STS reduced eosinophil necrosis, the infiltration of inflammatory cells, plasma levels of LDH, high mobility group protein B1, interleukin-1beta and tumor necrosis factor-alpha, and protein expression of these cytokines at 3 days.	tanshinone II A sodium sulfonate	25-28	interleukin 1 beta	Mus musculus	152-169
34949747-7	2022	In addition, GBP significantly stimulated mRNA expression levels of immune-associated genes including interleukin-1beta (IL-1beta), IL-2, IL-4, IL-6, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), Toll-like receptor 4 (TLR-4), and cyclooxygenase-2 (COX-2) in CY-treated mice.	Cyclophosphamide	283-285	interleukin 1 beta	Mus musculus	102-119
34961984-6	2022	Our findings indicated that, in the EAE spinal cord, tibolone reversed the astrocytic and microglial reaction, and reduced the hyperexpression of TLR4 and HMGB1, as well as NLR family pyrin domain containing 3-caspase 1-interleukin-1beta inflammasome activation.	tibolone	53-61	interleukin 1 beta	Mus musculus	220-237
34871838-7	2022	Additionally, Omarigliptin mitigated inflammatory response by inhibiting the expression of pro-inflammatory mediators, including interleukin-1beta (IL-1beta), interleukin-12 (IL-12), and macrophage chemoattractant protein-1 (MCP-1) in LPS-challenged BEAS-2B cells.	2-(2,5-difluorophenyl)-5-(2-(methylsulfonyl)-2,6-dihydropyrrolo(3,4-c)pyrazol-5(4H)-yl)tetrahydro-2H-pyran-3-amine	14-26	interleukin 1 beta	Mus musculus	129-146
34757175-6	2022	On day 4, PMSX-exposed mice also exhibited significant increases in interleukin-1 beta, tumor necrosis factor-alpha, and chemokine C-X-C motif ligands-3 and -5 mRNA, and monocyte chemoattractant protein-1 protein.	pmsx	10-14	interleukin 1 beta	Mus musculus	68-86
34964214-7	2022	In the DSS + DB group of male animals, disease activity index, myeloperoxidase activity, nitrite level, plasma lipopolysaccharides, interleukin-1beta, histological score, % fibrotic area, % TUNEL positive cells were significantly increased.	Dextran Sulfate	7-10	interleukin 1 beta	Mus musculus	132-149
34910341-10	2022	The expression levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), IL-6, and inducible nitric oxide synthase (iNOs) were down-regulated after infection in caffeine-treated mice.	Caffeine	184-192	interleukin 1 beta	Mus musculus	66-83
34908863-12	2021	Furthermore, in cultured dorsal root ganglion neurons, estrogen at physiological concentration elevated intracellular Mg2+, and downregulated phospho-p65, tumor necrosis factor-alpha and interleukin-1 beta exclusively in the presence of extracellular Mg2+.	magnesium ion	251-255	interleukin 1 beta	Mus musculus	187-205
34792426-7	2021	However, Tan IIA treatment markedly downregulated the expression levels of beta-hexosaminidase, histamine, tumor necrosis factor (TNF-alpha), interleukin 1beta (IL-1beta), IL-4, and IL-5 in IgE/HSA-induced cells.	tanshinone	9-16	interleukin 1 beta	Mus musculus	142-159
34806937-0	2021	Stigmasterol alleviates interleukin-1beta-induced chondrocyte injury by down-regulatingsterol regulatory element binding transcription factor 2 to regulateferroptosis.	Stigmasterol	0-12	interleukin 1 beta	Mus musculus	24-41
34747306-9	2021	The MPO activity and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and NLR family pyrin domain-containing 3) levels were also significantly reduced after DEX treatment compared with those in the ALI mice.	Dexmedetomidine	180-183	interleukin 1 beta	Mus musculus	74-91
34802285-7	2021	RESULTS: MTX increased activity level of serum enzymes (alanine aminotransferase and aspartate aminotransferase), lipid peroxidation marker (malondialdehyde), and inflammatory factors including interleukin-1 beta, tumor necrosis factor-alpha, and nitric oxide.	Methotrexate	9-12	interleukin 1 beta	Mus musculus	194-212
34749292-16	2021	GSDMD-/- attenuated interleukin-1beta (IL-1beta) level and peritoneal fibrosis induced by dextrose peritoneal dialysate treatment in pericytes in vivo.	Glucose	90-98	interleukin 1 beta	Mus musculus	20-37
33907040-6	2021	The results revealed that rutin pretreatment reduced the expression of the proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 and increased the secretion of interleukin-10.	Rutin	26-31	interleukin 1 beta	Mus musculus	130-147
34187277-13	2021	These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling.Abbreviation: Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1beta: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-alpha: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine.	tetrahydrocurcumin	29-32	interleukin 1 beta	Mus musculus	380-398
34537380-13	2021	The CB2 agonist HU308 strongly inhibited mBMDM M1-type polarization following stimulation with either IL-1beta or conditioned medium from IL-1beta-treated mFLS, which was characterized by reductions in Il1b, Mmp1b, and Il6 and increases in Cd206 gene expression.	HU 308	16-21	interleukin 1 beta	Mus musculus	202-206
34537380-14	2021	Cannabidiol similarly inhibited IL-1beta-induced mBMDM M1 polarization via a reduction in Il1b and an increase in Cd206 and Il4 gene expression.	Cannabidiol	0-11	interleukin 1 beta	Mus musculus	90-94
34400214-6	2021	Exposure to LPS increased interleukin-1 beta (IL-1beta), IL-6, and tumor necrosis factor alpha (TNF-alpha) in mice and HK-2 cells, but were reduced after Ala treatment.	alamandine	154-157	interleukin 1 beta	Mus musculus	26-44
34176379-6	2021	Ang II increased the expression of inflammatory cytokines tumor necross factor alpha and interleukin 1 beta and profibrotic factors transforming growth factor beta 1 and fibronectin in the heart, with was reduced by LEC treatment.	4-NITROPHENYL-N-ACETYL-BETA-D-GLUCOSAMINIDE	216-219	interleukin 1 beta	Mus musculus	89-107
34782991-13	2022	RESULTS: The results showed that low doses of Dex suppress NLRP3 and interleukin-1beta in both terms.	Dexmedetomidine	46-49	interleukin 1 beta	Mus musculus	69-86
34784929-6	2021	RESULTS: Compared with CS plus LPS-exposed mice, mice in the PJH-treated group showed significantly decreased inflammatory cells count and reduced inflammatory cytokines including interleukin-1 beta (IL-1beta), IL-6 and tumor necrosis factor alpha (TNF-alpha) levels in broncho-alveolar lavage fluid (BALF) and lung tissue.	N-Methylnicotinamide	61-64	interleukin 1 beta	Mus musculus	180-198
34571395-0	2021	Interaction of epigallocatechin-gallate and chlorhexidine with Streptococcus mutans stimulated odontoblast-like cells: Cytotoxicity, Interleukin-1beta and co-species proteomic analyses.	epigallocatechin gallate	15-39	interleukin 1 beta	Mus musculus	133-150
34747290-3	2021	It was suggested that the oleradazine can significantly inhibit the inflammatory factors, interleukin 1beta and nitric oxide in lipopolysaccharide-stimulated RAW 264.7 cells by enzyme-linked immunosorbent assays.	oleradazine	26-37	interleukin 1 beta	Mus musculus	90-107
34829903-5	2021	Compared to mice treated with only BLM, the administration of rGas6 reduced the secretion of proinflammatory cytokines, including tumor necrosis factor-alpha, interleukin-1beta, and macrophage inflammatory protein-2, and increased the secretion of hepatocyte growth factor in bronchoalveolar lavage (BAL) fluid.	rgas6	62-67	interleukin 1 beta	Mus musculus	159-176
34571395-0	2021	Interaction of epigallocatechin-gallate and chlorhexidine with Streptococcus mutans stimulated odontoblast-like cells: Cytotoxicity, Interleukin-1beta and co-species proteomic analyses.	Chlorhexidine	44-57	interleukin 1 beta	Mus musculus	133-150
34743632-9	2021	RESULTS: Compared with the dMCAO group, artesunate significantly improved neurological deficit scores and infarct volumes and ameliorated inflammation by reducing neutrophil infiltration, suppressing microglial activation, and downregulating tumor necrosis factor-alpha and interleukin-1beta expression.	Artesunate	40-50	interleukin 1 beta	Mus musculus	274-291
34649343-11	2021	Meanwhile, Andro-S effectively inhibited inflammatory response (interleukin 1beta and myeloperoxidase) induced by LPS.	andro-s	11-18	interleukin 1 beta	Mus musculus	64-81
34474343-9	2021	Furthermore, PC potently suppressed LPS-stimulated overproduction of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta) and IL-6 in RAW 264.7 macrophages.	pc	13-15	interleukin 1 beta	Mus musculus	154-171
34353430-6	2021	KHG26700 significantly attenuated the expression of several pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6, in these cells, as well as the LPS-induced increases in NLRP3, NF-kappaB, and phospho-IkBalpha levels.	khg26700	0-8	interleukin 1 beta	Mus musculus	127-144
34500036-8	2021	Microglia in the hippocampus of the 5xFAD-FMT mice were activated, which caused the elevation of pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1beta).	5xfad-fmt	36-45	interleukin 1 beta	Mus musculus	157-174
34624602-7	2021	RESULTS: Ablation of Gstp decreased total S-glutathionylation and attenuated HDM-induced allergic airways disease and interleukin-1beta-mediated inflammation.	gstp	21-25	interleukin 1 beta	Mus musculus	118-135
34666120-11	2021	Minocycline also inhibited the activation of microglia/macrophages, infiltration of neutrophils, and production of inflammatory mediators, including tumor necrosis factor alpha and interleukin-1beta.	Minocycline	0-11	interleukin 1 beta	Mus musculus	181-198
34624602-8	2021	Gstp deletion or inhibition by TLK199 decreased the interleukin-1beta-stimulated secretion of pro-inflammatory mediators and lactate by epithelial cells.	Lactic Acid	125-132	interleukin 1 beta	Mus musculus	52-69
34764855-8	2021	by TFP for 4 weeks was able to reduce the levels of plasma tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in accompany with lower levels of plasma glucose and insulin in obese mice receiving HFD for 16 weeks when compared those in obese mice without TFP treatment.	Trifluoperazine	3-6	interleukin 1 beta	Mus musculus	103-120
34652342-10	2021	The levels of Nos2, Il1b, Tnf, and Il6 were decreased while Il10 and Hmox1 mRNA levels were significantly up-regulated upon LPS stimulation of TCW pretreated RAW264.7 macrophages.	Tolcapone	143-146	interleukin 1 beta	Mus musculus	20-24
34951178-7	2021	The levels of cysteinyl aspartate specific proteinase-1(caspase-1), interleukin-1beta(IL-1beta), and IL-18 in the supernatant of J774 A.1 mononuclear phagocytes were detected to evaluate the effect of LRH flavonoids on the pyroptosis of mononuclear phagocytes in mice induced by the combination of lipopolysaccharide(LPS) and adenosine triphosphate(ATP).	Adenosine	326-335	interleukin 1 beta	Mus musculus	68-85
34778302-13	2021	The inflammatory cytokines and chemokines, such as TNFalpha, IL1b, IL-6, and CXCL1, were also kept in check in responder AstroRx-treated mice and were not upregulated as in the sham-injected mice (P < 0.05).	astrorx	121-128	interleukin 1 beta	Mus musculus	61-65
34679730-6	2021	Simultaneously, ZER attenuated the inflammatory response via significantly reducing the levels of pro-inflammatory factors, including interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) in serum.	Cerium	16-19	interleukin 1 beta	Mus musculus	134-151
34745126-3	2021	Aspartate promotes interleukin-1beta (IL-1beta) secretion in M1 macrophages.	Aspartic Acid	0-9	interleukin 1 beta	Mus musculus	19-36
34684576-7	2021	Oral gavage with ASTX inhibited osteoclastic formation and the expression of receptor activator of nuclear factor (NF)-kappaB ligand, 8-OHdG, gamma-H2AX, cyclooxygenase 2, and interleukin-1beta in the periodontium of STZ-injected mice.	Streptozocin	217-220	interleukin 1 beta	Mus musculus	176-193
34684576-7	2021	Oral gavage with ASTX inhibited osteoclastic formation and the expression of receptor activator of nuclear factor (NF)-kappaB ligand, 8-OHdG, gamma-H2AX, cyclooxygenase 2, and interleukin-1beta in the periodontium of STZ-injected mice.	astaxanthine	17-21	interleukin 1 beta	Mus musculus	176-193
34628369-10	2021	Collectively, our novel findings for first time showed that, Schisandrin B suppressed NLRP3 inflammasome activation-mediated interleukin-1beta (IL-1beta) level and pyroptosis in intestinal epithelial cells of colitis model through the activation of AMPK/Nrf2 dependent signaling-ROS-induced mitochondrial damage, which may be a significant therapeutic approach in the treatment of acute colitis.	schizandrin B	61-74	interleukin 1 beta	Mus musculus	125-142
34588910-9	2021	ASPP 092 treatment also modulated the expressions of inflammatory cytokines including Tumor Necrosis Factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-10 (IL-10), interleukin-1beta (IL-1beta), and Matrix metalloproteinase-13 (MMP-13).	(3S)-7-(3,4-dihydroxyphenyl)-1-phenyl-(1E)-1-hepten-3-ol	0-8	interleukin 1 beta	Mus musculus	173-190
34600581-8	2021	The effect of shikonin on expression of interleukin-6, interleukin-1beta and tumor necrosis factor-alpha was measured by enzyme linked immunosorbent assay.	shikonin	14-22	interleukin 1 beta	Mus musculus	55-72
34600581-13	2021	Meanwhile, shikonin suppressed tumor necrosis factor-alpha-induced invasion, adhesion and migration of fibroblast like synoviocytes and reduced the expression of interleukin-6, interleukin-1beta and tumor necrosis factor-alpha.	shikonin	11-19	interleukin 1 beta	Mus musculus	177-194
34705177-0	2021	Effect of Tilorone on the Dynamics of Viral Load and the Levels of Interferons and Interleukin-1beta in the Lung Tissue and Blood Serum of Mice with Experimental Influenza.	Tilorone	10-18	interleukin 1 beta	Mus musculus	83-100
34303280-4	2021	As a result, (-)-SYR significantly reduced lipopolysaccharide (LPS)-induced production of interleukin - 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), interleukin -1 beta (IL-1beta), cycloxygenase-2 (COX-2), and nitric oxide (NO) in BV2 microglia cells.	syringaresinol	17-20	interleukin 1 beta	Mus musculus	155-174
34255249-8	2021	Moreover, kojic acid decreased neuroinflammation by inhibiting Toll-like receptor 4, phosphorylated nuclear factor-kappaB, tumor necrosis factor-alpha, interleukin 1-beta (TLR-4, p-NFkappaB, TNFalpha, and IL-1beta, respectively), and glial cells.	kojic acid	10-20	interleukin 1 beta	Mus musculus	152-170
34684537-4	2021	In RAW264.7 cells, 4,5-diCQA pretreatment significantly inhibited lipopolysaccharide-induced expression of nitric oxide, prostaglandin E2, nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6, without inducing cytotoxicity.	4,5-dicaffeoyl quinic acid	19-28	interleukin 1 beta	Mus musculus	209-226
34329731-6	2021	Oxysophoridine abolished Abeta-induced increase of mRNA expression, secretion, and protein expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin 1beta (IL-1beta) in BV-2 cells.	oxysophoridine	0-14	interleukin 1 beta	Mus musculus	149-166
34560074-8	2022	In RNA-seq analyses of SDS-treated skin, the expression levels of Il1b in CCR2-deficient mice were highly downregulated compared with those in wild-type mice.	Sodium Dodecyl Sulfate	23-26	interleukin 1 beta	Mus musculus	66-70
34076707-3	2021	This study aims to investigate the effects of FSTL1 in ovalbumin (OVA)-induced mice and macrophages on nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3)/interleukin-1beta (IL-1beta) signaling pathway.	Leucine	133-140	interleukin 1 beta	Mus musculus	171-188
34537189-7	2022	More importantly, transfection of keratinocytes with dsDNA synergized with TNF-alpha or H2O2 to induce STING-dependent activation of NF-kappaB and subsequent expression of Il1b, Ccl20, and Cxcl10.	Hydrogen Peroxide	88-92	interleukin 1 beta	Mus musculus	172-176
34576099-5	2021	Exposure of isolated macrophages to MC-LR was found to directly upregulate macrophage activation markers Tnf and Il1b.	cyanoginosin LR	36-41	interleukin 1 beta	Mus musculus	113-117
34552579-8	2021	Meanwhile, MIF ingestion reduced (p < 0.05) the colonic interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) concentrations and increased the superoxide dismutase and catalase activities and Shannon and Simpson indices in DSS-challenged mice.	Dextran Sulfate	273-276	interleukin 1 beta	Mus musculus	56-73
34500784-3	2021	The effects of 6-MC on the production and levels of pro-inflammatory cytokines (interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha) and inflammatory mediators (nitric oxide (NO), prostaglandin E2 (PGE2)) in LPS-stimulated RAW 264.7 cells were examined.	6-methylcoumarin	15-19	interleukin 1 beta	Mus musculus	79-102
34571925-6	2021	Moreover, ALA suppressed CdCl2-induced glial fibrillary acidic protein (GFAP), nuclear factor-kappa b (NF-kappaB), and interleukin-1beta (IL-1beta) in the mouse brain.	alpha-Linolenic Acid	10-13	interleukin 1 beta	Mus musculus	119-136
34571925-6	2021	Moreover, ALA suppressed CdCl2-induced glial fibrillary acidic protein (GFAP), nuclear factor-kappa b (NF-kappaB), and interleukin-1beta (IL-1beta) in the mouse brain.	Cadmium Chloride	25-30	interleukin 1 beta	Mus musculus	119-136
34531308-5	2021	Moreover, in AbetaO-injected male mice, a 2-week administration of SAR439883 in diet dose-dependently ameliorated the AbetaO-induced cognitive impairment in both Y-maze and Morris Water Maze, prevented loss of synaptic proteins, and reduced levels of the proinflammatory cytokine interleukin-1beta In both mouse models, these effects were associated with a dose-dependent inhibition of brain PKR activity as measured by both PKR occupancy and partial lowering of peIF2alpha levels.	sar439883	67-76	interleukin 1 beta	Mus musculus	280-297
33510091-4	2021	The results showed that: (1) VX-765 inhibited spinal cord injury-induced caspase-1 activation and interleukin-1beta and interleukin-18 secretion.	belnacasan	29-35	interleukin 1 beta	Mus musculus	98-115
33510091-9	2021	These findings suggest that VX-765 can reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1beta/interleukin-18.	belnacasan	28-34	interleukin 1 beta	Mus musculus	149-166
34577821-2	2021	The triggering of MSU leads to increased production of inflammatory cytokines, such as interleukin-1beta, which in turn lead to the formation of macromolecular complexes, referred to as inflammasomes.	Uric Acid	18-21	interleukin 1 beta	Mus musculus	87-104
34452266-4	2021	RESULTS AND CONCLUSION: Compared with sham (no PB), the treated group showed significant reduction in serum levels of interleukin-1beta, interleukin-6, interleukin-12, interleukin-17, and tumour necrosis factor-alpha, accompanied by a 3-fold increase in survival duration, which suggests PB islet-protective effects, post transplantation.	Probucol	288-290	interleukin 1 beta	Mus musculus	118-135
34376811-2	2022	Although MSU crystal-triggered NLRP3 inflammasome activation and interleukin 1beta (IL-1beta) release are known to have key roles in gouty arthritis, recent studies revealed that MSU crystal-induced necrosis also plays a critical role in this process.	Uric Acid	9-12	interleukin 1 beta	Mus musculus	65-82
34376811-2	2022	Although MSU crystal-triggered NLRP3 inflammasome activation and interleukin 1beta (IL-1beta) release are known to have key roles in gouty arthritis, recent studies revealed that MSU crystal-induced necrosis also plays a critical role in this process.	Uric Acid	179-182	interleukin 1 beta	Mus musculus	65-82
34272410-7	2021	Comp23 treatment attenuated the ex vivo permeability of colonic sacs, the clinical symptoms, and mucosal expression of Tgfb1, Il1b, Il6 and Il10 of DSS-treated mice.	dss	148-151	interleukin 1 beta	Mus musculus	126-130
34506597-6	2021	24 hours following the final injury, rmTBI causes an upregulation in mRNA levels of NLRP3, caspase-1, the apoptosis-associated speck-like protein containing a CARD (ASC), nuclear factor kappa B (NF-kappaB), interleukin-1Beta (IL-1beta), interleukin 18 (IL-18), nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1).	rmtbi	37-42	interleukin 1 beta	Mus musculus	207-224
34541001-12	2021	Moreover, PIH administration inhibited proinflammatory polarization and reduced interleukin-1 beta and tumor necrosis factor alpha in ICH mice.	pyridoxal isonicotinoyl hydrazone	10-13	interleukin 1 beta	Mus musculus	80-98
34198045-0	2021	The novel piperazino-enaminone JOAB-40 reduced colitis severity in mice via inhibition tumor necrosis factor-alpha and interleukin-1beta.	piperazino-enaminone	10-30	interleukin 1 beta	Mus musculus	119-136
34198045-0	2021	The novel piperazino-enaminone JOAB-40 reduced colitis severity in mice via inhibition tumor necrosis factor-alpha and interleukin-1beta.	joab-40	31-38	interleukin 1 beta	Mus musculus	119-136
34250696-13	2021	Rosmarinic acid downregulated the cytokines like interleukin-6, tumor necrosis factor-alpha, interleukin-1beta; inflammatory parameter includes prostaglandin E2 , cyclooxygenase-2, and inducible nitric oxide synthase at a dose-dependently.	rosmarinic acid	0-15	interleukin 1 beta	Mus musculus	93-110
34589820-8	2021	Further, CPA suppressed expression of brain-derived neurotrophic factor (BDNF) and pro-inflammatory cytokine interleukin-1 beta in the hippocampus.	cpa	9-12	interleukin 1 beta	Mus musculus	109-127
34497527-7	2021	We found that clemastine ameliorated PND and reduced the expression levels of inflammatory factors such as tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta).	Clemastine	14-24	interleukin 1 beta	Mus musculus	151-169
34156157-6	2021	Moreover, Atractylenolide III downregulated the expression levels of the inflammatory factors interleukin-1beta and tumor necrosis factor-alpha, and greatly suppressed the levels of the pro-oxidant markers, reactive oxygen species and malondialdehyde, while enhancing the expression levels of the antioxidant enzymes catalase, superoxide dismutase and glutathione peroxidase.	atractylenolide III	10-29	interleukin 1 beta	Mus musculus	94-111
34124763-5	2021	BEOV administration significantly decreased the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) both in the hippocampus of APPswe/PS1E9 mice and in the Abeta-stimulated BV2 microglia.	beov	0-4	interleukin 1 beta	Mus musculus	121-138
34162163-4	2021	The results showed that varying doses of TH-GLs can significantly improve colon lesions caused by DSS, reduce histological scores, increase mucus secretion, extend colon length, increase weight, and inhibit the occurrence of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), Interleukin-1beta (IL-1beta), and Interleukin- 6 (IL-6).	th-gls	41-47	interleukin 1 beta	Mus musculus	327-344
34209652-6	2021	We further reveal that DON exposure increased the intracellular reactive oxygen species level, reduced the mitochondrial membrane potential and ATP, and upregulated Tnfalpha (tumor necrosis factor alpha), Il6 (interleukin 6), and Il1beta (interleukin 1 beta) gene expression.	deoxynivalenol	23-26	interleukin 1 beta	Mus musculus	239-257
34358312-11	2021	Rutin co-administration also caused a significant (P < 0.001) increase in tumor necrosis factor-alpha, interleukin-6, and immunoglobulin M levels, while interleukin-1beta and immunoglobulin G decreased significantly (P < 0.001) compared with parasitized control.	Rutin	0-5	interleukin 1 beta	Mus musculus	153-170
34261702-8	2021	Blocking CTLA4 and IL1B with the specific mAbs significantly suppressed tumor progression and metastasis in the mouse models resistant to anti-PD1 therapy, and the therapeutic efficacy was optimized by blocking cyclooxygenases with aspirin.	Aspirin	232-239	interleukin 1 beta	Mus musculus	19-23
34168409-10	2021	The inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta, were induced in the DSS-treated mice, in which the depletion of EZH2 could reverse this effect.	dss	123-126	interleukin 1 beta	Mus musculus	84-101
34071363-5	2021	In addition, the expression of two prototypic inflammatory enzymes, cyclooxygenase-2 and inducible nitric oxide synthase, and transcription of some pro-inflammatory cytokines (Tnf, Il6, Il1b, Il10) were significantly lower in TauCl-treated mice than vehicle-treated control mice.	N-chlorotaurine	226-231	interleukin 1 beta	Mus musculus	186-190
34234834-8	2021	KXS protected against DOX-induced neuroinflammation by decreasing levels of proinflammatory cytokines interleukin-6, interleukin-12p70, and tumor necrosis factor-alpha in both serum and brain and interleukin-1beta in the brain, increasing the anti-inflammatory cytokines interleukin-4 in the serum and interleukin-10 in the hippocampus, and inhibiting the astrocytic hyperplasia and microglial polarization in the hippocampus.	Doxorubicin	22-25	interleukin 1 beta	Mus musculus	196-213
34423275-1	2021	Nucleotide-binding domain leucine-rich repeat family pyrin domain containing 3 (NLRP3) inflammasome complex regulates the caspase-1 activity and subsequent processing of interleukin-1beta (IL-1beta).	Leucine	26-33	interleukin 1 beta	Mus musculus	170-187
35415762-9	2022	Inhibition of ER stress by 4-PBA decreased the expression of vital proinflammatory cytokines, tumor necrosis factor alpha, and interleukin-1 beta; and suppressed the activation of retinal microglial cells and nuclear factor-kappa B (NF-kappaB).	4-phenylbutyric acid	27-32	interleukin 1 beta	Mus musculus	127-145
34188435-8	2021	Tumor necrosis factor alpha (TNF-alpha) and interleukin-1-beta (IL-1beta) levels were statistically significantly reduced after administration of forskolin eye drops compared to I/R alone.	Colforsin	146-155	interleukin 1 beta	Mus musculus	44-62
34193671-13	2021	BB treatment considerably reduced the cytokines include tumor necrosis factor-alpha (TNF-alpha), interleukin-18 (IL-18), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and inflammatory parameters such as transforming growth factor beta 1 (TGF-beta1), prostaglandin E2 (PGE2), nuclear kappa B factor (NF-kappaB) and cycloxgenase-2 (COX-2) in DMBA/croton-induced skin cancer mice.	boeravinone B	0-2	interleukin 1 beta	Mus musculus	121-138
35452774-9	2022	Anti-inflammatory test indicated that steroidal alkaloids could decrease the expression of cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1beta), and tumor necrosis factor alpha (TNF-alpha) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells at a concentration of 5.0 mug/ml in vitro, comparable to DXM.	Alkaloids	48-57	interleukin 1 beta	Mus musculus	117-134
35278152-12	2022	The transfection of miR-629-3p mimics inhibited 16HBE cells" viability, and promoted the apoptosis and the secretion of chemokines CCL11, CCL26, CCL-2/MCP-1, IL-1b, and IL-6 of 16HBE cells, whereas inhibiting miR-629-3p had the opposite effects.	mir-629-3p	20-30	interleukin 1 beta	Mus musculus	158-163
35088269-7	2022	Additionally, ACR treatment caused an inflammatory response via nuclear factor-kappa B (NF-kappaB) activation and increased the protein expression of NOD-like receptor protein-3 (NLRP3), consequently activating the NLRP3 inflammasome constituents, including cysteinyl aspartate specific proteinase 1 (Caspase-1), apoptosis-associated speck-like protein containing CARD (ASC), N domain gasdermin D (N-GSDMD), interleukin-1beta (IL-1beta), and IL-18.	Acrylamide	14-17	interleukin 1 beta	Mus musculus	408-425
34122726-8	2021	In addition, melatonin treatment remarkably reduced the inflammatory cytokines of interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNFalpha), and transforming growth factor beta (TGFbeta) in vivo and in vitro.	Melatonin	13-22	interleukin 1 beta	Mus musculus	82-99
34065421-8	2021	Pathway analysis showed IL10 signaling as a major contributing pathway to the altered immunophenotype after Rapamycin treatment compared to vehicle with significantly lower cytokines Tnfa, Il1b, and Il6, while regulators of mitochondrial content Pgc1a, Tfam, and Ho1 remained elevated.	Sirolimus	108-117	interleukin 1 beta	Mus musculus	189-193
35588841-4	2022	Mice fed with NCD or HFD both showed insulin resistance (IR) after PS exposure accompanied by increased plasma lipopolysaccharide and pro-inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-1beta.	Polystyrenes	67-69	interleukin 1 beta	Mus musculus	201-218
35446130-8	2022	Additionally, the retinas of the TatCARD treated mice exhibited a significant decline in the concentration of interleukin-1 beta (IL-1beta) concomitant with modulation of several inflammatory cytokines in the retina and RPE-choroid tissues, as measured by ELISA and cytokine array, respectively.	tatcard	33-40	interleukin 1 beta	Mus musculus	110-128
35338958-10	2022	In addition, ManNAc administration attenuated podocyte cell death and suppressed the activation of Nucleotide leukin-rich polypeptide 3 (NLRP3), caspase-1, and interleukin-1beta (IL-1beta), and the cleavage of gasdermin-D (GSDMD).	N-acetylmannosamine	13-19	interleukin 1 beta	Mus musculus	160-177
35122975-12	2022	The levels of inflammatory factors, including tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 were significantly reduced after quercetin administration.	Quercetin	144-153	interleukin 1 beta	Mus musculus	75-92
35306095-9	2022	LL95 treatment reversed the LPS-induced increase in hippocampal levels of reactive oxygen species and tumor necrosis factor-alpha, and of interleukin-1beta to a lesser extent.	ll95	0-4	interleukin 1 beta	Mus musculus	138-155
35314251-9	2022	In I/R mice, PCA pPoCo attenuated lipid peroxidation, inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, interleukin-6), and myeloperoxidase activity.	ppoco	17-22	interleukin 1 beta	Mus musculus	107-124
35596224-12	2022	Mechanistically, intestinal tissue obtained from mice fed with stool from BBR treated AOM/DSS mice demonstrated a decreased expression of inflammatory cytokines including interleukin 1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), C-C motif chemokine 1 (Ccl1), Ccl6, and C-X-C motif ligand (Cxcl9).	Dextran Sulfate	90-93	interleukin 1 beta	Mus musculus	171-188
35614939-7	2022	Furthermore, high-dose OCA induced cholesterol accumulation in livers via the upregulation of genes involved in cholesterol acquisition and downregulation of genes regulating cholesterol degradation in liver, leading to the production of interleukin -1beta and an FXR-mediated inflammatory response.	obeticholic acid	23-26	interleukin 1 beta	Mus musculus	238-256
35605433-4	2022	The results showed that DMF suppressed the activation of NLRP3 inflammasome activation in lipopolysaccharide-primed murine bone marrow-derived macrophages upon ATP or nigericin treatment, as evidenced by reduced cleavage of pro-caspase-1, release of mature interleukin-1beta (IL-1beta) and generation of gasdermin D N-terminal fragment (GSDMD-NT).	Dimethyl Fumarate	24-27	interleukin 1 beta	Mus musculus	257-274
35546374-7	2022	L. gasseri CCFM1201 significantly reduced G. vaginalis in mice (p < 0.05), inhibited sialidase activity, modulated tumor necrosis factor-alpha and interleukin-1beta expression, and reduced myeloperoxidase activity (p < 0.05).	ccfm1201	11-19	interleukin 1 beta	Mus musculus	147-164
35614939-7	2022	Furthermore, high-dose OCA induced cholesterol accumulation in livers via the upregulation of genes involved in cholesterol acquisition and downregulation of genes regulating cholesterol degradation in liver, leading to the production of interleukin -1beta and an FXR-mediated inflammatory response.	Cholesterol	175-186	interleukin 1 beta	Mus musculus	238-256
35614939-8	2022	Conclusion: The high-dose OCA induced FXR-dependent hepatic injury via cholesterol accumulation and interleukin -1beta pathway in the NAFLD mice.	obeticholic acid	26-29	interleukin 1 beta	Mus musculus	100-118
35545052-7	2022	Small interfering RNA (siRNA-based) silencing of each of these genes suppresses lipopolysaccharide- and ATP-induced inflammasome activation, as determined by interleukin-1beta release from primary cultured murine microglia.	Adenosine Triphosphate	104-107	interleukin 1 beta	Mus musculus	158-175
35614939-7	2022	Furthermore, high-dose OCA induced cholesterol accumulation in livers via the upregulation of genes involved in cholesterol acquisition and downregulation of genes regulating cholesterol degradation in liver, leading to the production of interleukin -1beta and an FXR-mediated inflammatory response.	Cholesterol	35-46	interleukin 1 beta	Mus musculus	238-256
35421705-5	2022	Taurine supplementation decreased the expressions of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) in LPS-challenged neutrophils and monocytes and reduced the formation of neutrophil extracellular traps by restricting reactive oxygen species.	Taurine	0-7	interleukin 1 beta	Mus musculus	94-111
35507968-4	2022	METHODS: PCCL was orally administered at a dose of 20 mg kg-1 for 7 days and its protective effect on 5-FU-induced IM (5-FU, 50 mg kg-1 for 5 days) was evaluated by monitoring changes in body weight, degree of diarrhea, levels of tissue inflammatory factors (tumor necrosis factor alpha, interleukin 6, and interleukin 1beta levels), apoptosis rates, and the expression levels of caspase-3, Bax and Bcl-2.	pccl	9-13	interleukin 1 beta	Mus musculus	307-324
35513246-10	2022	HIF-2alpha, ZIP8, and interleukin-1beta could upregulate matrix-degrading enzymes in chondrocytes and FLS, and the rhodanine derivatives inhibited these effects.	Rhodanine	115-124	interleukin 1 beta	Mus musculus	22-39
35192424-6	2022	Enzyme-linked immunosorbent assays and Western blotting revealed that inflammatory cytokine (interleukin-1beta, interleukin-18 and C-C motif chemokine ligand 5) expression was induced by H2O2 treatment and that circ_0007059 repressed H2O2-induced inflammation.	Hydrogen Peroxide	187-191	interleukin 1 beta	Mus musculus	93-110
35192424-6	2022	Enzyme-linked immunosorbent assays and Western blotting revealed that inflammatory cytokine (interleukin-1beta, interleukin-18 and C-C motif chemokine ligand 5) expression was induced by H2O2 treatment and that circ_0007059 repressed H2O2-induced inflammation.	Hydrogen Peroxide	234-238	interleukin 1 beta	Mus musculus	93-110
35574050-5	2023	Further, CTP-MSCs inhibited extracellular matrix degradation in interleukin-1beta-induced chondrocytes.	Cytidine Triphosphate	9-12	interleukin 1 beta	Mus musculus	64-81
35549989-2	2022	The results showed that the overexpression of lincRNA-EPS was able to reduce the levels of interleukin-6, tumor necrosis factor-alpha and interleukin-1beta stimulated in the OGD-treated Neuro-2a (N-2a) cells.	lincrna-eps	46-57	interleukin 1 beta	Mus musculus	138-155
35218798-5	2022	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-1beta (IL-1beta), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-kappaB) and signal transducer and activator of transcription 3 (STAT3) pathways.	psb	13-16	interleukin 1 beta	Mus musculus	143-160
35149295-8	2022	Evidently, Icariin prevented the neutrophilia/lymphopenia caused by CYP, and markedly improved the antioxidant enzymes level including superoxide dismutase, glutathione sulfo-transferase, catalase, glutathione level and reduced Malondialdehyde level, myeloperoxidase activity and nitric oxide, and also decreased the production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) in bladder.	icariin	11-18	interleukin 1 beta	Mus musculus	375-393
35487253-5	2022	Ethanol-induced acute gastric ulcer was restored by OCT alone at doses of 2.5 mg/kg, or combined with OME as indicated by markedly reducing Gastrin, Il-6 and Il1b expression through induction of Muc5ac and Occludin, significantly improving hyperacidity and gastric bleeding.	Ethanol	0-7	interleukin 1 beta	Mus musculus	158-162
35248848-7	2022	HT suppressed expression levels of NLRP3, caspase-1, and ASC mRNA and downregulated interleukin-18 and interleukin-1beta levels in the DSS group (P < 0.01).	dss	135-138	interleukin 1 beta	Mus musculus	103-120
35611788-11	2022	Gene expression of proinflammatory cytokines and their receptors were largely stable across groups, although SS-31 treatment led to greater mRNA expression of IL1B, TNF, and TNFRSF12A.	arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide	109-114	interleukin 1 beta	Mus musculus	159-163
35373399-9	2022	Moreover, SI treatment significantly suppressed nuclear factor kappa B p65, nitric oxide synthase, and cyclooxygenase 2 activation, as well as the pro-inflammatory cytokines (Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta)) release in the hippocampus of CSD-treated mice.	Isoflavones	10-12	interleukin 1 beta	Mus musculus	242-259
35487253-5	2022	Ethanol-induced acute gastric ulcer was restored by OCT alone at doses of 2.5 mg/kg, or combined with OME as indicated by markedly reducing Gastrin, Il-6 and Il1b expression through induction of Muc5ac and Occludin, significantly improving hyperacidity and gastric bleeding.	Octreotide	52-55	interleukin 1 beta	Mus musculus	158-162
35487253-5	2022	Ethanol-induced acute gastric ulcer was restored by OCT alone at doses of 2.5 mg/kg, or combined with OME as indicated by markedly reducing Gastrin, Il-6 and Il1b expression through induction of Muc5ac and Occludin, significantly improving hyperacidity and gastric bleeding.	Omeprazole	102-105	interleukin 1 beta	Mus musculus	158-162
35089476-3	2022	In this study, we aimed to investigate the contribution of US to AX incorporation to compensate for the limited incorporation of AX, and regulation of the pro-inflammatory factor interleukin-1beta (IL-1beta) by AX.	astaxanthine	211-213	interleukin 1 beta	Mus musculus	179-196
35383532-9	2022	In conclusion, the dual GLP-1/GIP receptor agonist, AP5, can effectively improve diabetic symptoms and exert therapeutic effects on DCM via activating the AMPK/PI3K/Akt pathway, reducing the ROS production, oxidative stress and inflammatory markers in the rodent DCM model.Abbreviation: Diabetes mellitus, DM; diabetic cardiomyopathy, DCM; streptozotocin, STZ; glucagon-like peptide-1, GLP-1; malondialdehyde, MDA; glucose-dependent insulinotropic polypeptide, GIP; creatine kinase, CK; diabetic cardiomyopathy, DCM; serum superoxide dismutase; SOD; total superoxide disumutase, T-SOD; Methyl Thiazolyl Tetrazolium, MTT; lactate dehydrogenase; LDH; Adenosine Monophosphate-Activated Protein Kinase, AMPK; Dulbecco"s modified Eagle medium, DMEM; Fetal Bovine Serum, FBS; Reactive Oxygen Species, ROS; Glyceraldehyde-phosphate dehydrogenase, GAPDH; Surface Plasmon Resonance, SPR; Ethylene Diamine Tetraacetic Acid, EDTA; Interleukin-1beta, IL-1beta; Phosphoinositol 3-kinase, PI3K; Tumor necrosis factor, TNF-alpha; Renin-angiotensin-aldosterone system, RAAS; Glucose transporter, GLUT; Dipeptidyl peptidase-IV, DPP-IV; oxygen free radicals, OFR.	ap5	52-55	interleukin 1 beta	Mus musculus	920-937
35217279-7	2022	RESULTS: The results showed that SYQ treatment obviously attenuated LPS-induced intestinal injury and reduced the production of tumor necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta), and interleukin 6 (IL-6).	(S)-N-(1-cyclopropylethyl)-6-methylpicolinamide	33-36	interleukin 1 beta	Mus musculus	169-186
35447899-4	2022	The content of interleukin-1beta in the FFA group was 89.3 +- 3.6 ng/mL, while that in the H-Fx group was reduced to 53.8 +- 2.8 ng/mL.	Fatty Acids, Nonesterified	40-43	interleukin 1 beta	Mus musculus	15-32
35167638-6	2022	Pb(Ac)2 exposure significantly increased cellular oxidative damage and the levels of pro-inflammatory cytokines (interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha (TNF-alpha), ionized calcium binding adaptor molecule 1 (Iba1) and pro-apoptotic proteins (caspase 3, caspase 9 and Bax), while downregulating the expression of Bcl-2 in the brain.	pb(ac)2	0-7	interleukin 1 beta	Mus musculus	112-135
35405969-2	2022	In LPS-stimulated RAW264.7 cells, a 100 microg/mL dose of SCLE significantly reduced the production of nitric oxide (NO), interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and prostaglandin E2 (PGE2).	scle	58-62	interleukin 1 beta	Mus musculus	122-139
35093323-11	2022	Treatment with loureirin B inhibited the elevation of inflammatory factors (interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha), transforming growth factor-beta1 (TGF-beta1), and Pin1 induced by TAC.	loureirin B	15-26	interleukin 1 beta	Mus musculus	76-93
35308280-4	2022	LP-KFY05 could also reduce tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1beta) levels in sera and renal tissues of thrombotic mice.	lp-kfy05	0-8	interleukin 1 beta	Mus musculus	94-112
35093323-11	2022	Treatment with loureirin B inhibited the elevation of inflammatory factors (interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha), transforming growth factor-beta1 (TGF-beta1), and Pin1 induced by TAC.	tac	210-213	interleukin 1 beta	Mus musculus	76-93
35530143-7	2022	Measurement of interleukin-1beta release, lactic dehydrogenase activity, and real-time propidium iodide staining further revealed that silica induced pyroptosis of macrophages.	Silicon Dioxide	135-141	interleukin 1 beta	Mus musculus	15-32
35268775-6	2022	Furthermore, RPP-2a exhibited significant macrophage activation activity by increasing the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and the expression of inducible nitric oxide synthase (iNOS) and cytokines at the transcriptional level in RAW264.7 cells.	rpp-2a	13-19	interleukin 1 beta	Mus musculus	187-204
35074592-8	2022	The tissue levels of tumor necrosis factor-alpha, interleukin-1beta, and NFKB were also significantly higher with CsA treatment.	Cyclosporine	114-117	interleukin 1 beta	Mus musculus	50-67
35163768-7	2022	Buspirone attenuated the induction of interleukin-1beta and interleukin-6 expression by rotenone, and this was paralleled by the upregulation of arginase-1, brain-derived neurotrophic factor (BDNF), and activity-dependent neuroprotective protein (ADNP) in the midbrain, striatum, prefrontal cortex, amygdala, and hippocampus.	Buspirone	0-9	interleukin 1 beta	Mus musculus	38-55
35138518-7	2022	The serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1-beta (IL-1beta) and interleukin-6 (IL-6) were significantly decreased by TP in HFD-fed mice.	tp	148-150	interleukin 1 beta	Mus musculus	61-79
35181718-9	2022	Moreover, bone marrow derived macrophages isolated from P2X4-deficient mice revealed a reduced ATP-mediated release of CCL-2, CC chemokine ligand 5 (CCL-5), Interleukin-1beta (IL-1beta) and IL-6.	Adenosine Triphosphate	95-98	interleukin 1 beta	Mus musculus	157-174
35099982-7	2022	Moreover, these surface-engineered Au nanoparticles were found to be suitable in subsiding key pro-inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta).	Gold	35-37	interleukin 1 beta	Mus musculus	197-214
35163768-7	2022	Buspirone attenuated the induction of interleukin-1beta and interleukin-6 expression by rotenone, and this was paralleled by the upregulation of arginase-1, brain-derived neurotrophic factor (BDNF), and activity-dependent neuroprotective protein (ADNP) in the midbrain, striatum, prefrontal cortex, amygdala, and hippocampus.	Rotenone	88-96	interleukin 1 beta	Mus musculus	38-55
35145506-6	2022	Our results showed that diet of beta-carotin and green tea powder reduced the joint swelling and pain in mice with gout, reduced the levels of serum uric acid (UA) and three types of pro-inflammatory cytokines, i.e., interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), improved the gut microbiota profile, and reduced the metabolic levels of purines and pyrimidines.	beta Carotene	32-44	interleukin 1 beta	Mus musculus	217-234
35090386-7	2022	RESULTS: Omega-3 FAs inhibited CLP-induced intestinal injury and ameliorated LPS-induced intestinal epithelial cell injury by down-regulating miR-1-3p, as evidenced by decreased levels of tumor necrosis factor-alpha, interleukin-1beta (IL-1beta) and IL-6, in addition to diminished levels of reactive oxygen species, malondialdehyde levels and superoxide dismutase activity.	Fatty Acids, Omega-3	9-20	interleukin 1 beta	Mus musculus	217-234
35023338-7	2022	Importantly, 1 mg Se/kg BW/day SeNPs alleviated the microglial ramification index as well as solidity changes and decreased the interleukin-1beta secretion induced by F by suppressing the p-STAT3 nuclear translocation (P < 0.01).	Fluorides	167-168	interleukin 1 beta	Mus musculus	128-145
35178419-7	2021	In vitro immunostimulating assays indicated that DCP activates RAW264.7 cells, thus markedly promoting macrophage proliferation and phagocytosis and increasing the levels of nitric oxide, interferon-gamma, interleukin-6, and interleukin-1beta.	dcp	49-52	interleukin 1 beta	Mus musculus	225-242
35161266-8	2022	ETL dose-dependently reduced the production of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) in LPS-induced RAW264.7 cells, in a dose-dependent manner.	etl	0-3	interleukin 1 beta	Mus musculus	125-142
35127716-7	2021	In addition, sevoflurane mediated cleavage of gasdermin D (GSDMD) but not gasdermin E (GSDME), promoted the biosynthesis of downstream interleukin-1beta and interleukin-18, and increased beta-amyloid (Abeta) deposition and tau phosphorylation.	Sevoflurane	13-24	interleukin 1 beta	Mus musculus	135-152
35041781-18	2022	Likewise, only Reg-WPS induced an increase in proinflammatory cytokines, tumor necrosis factor-alpha and interleukin-1beta compared with either control or Occ-WPS groups.	reg-wps	15-22	interleukin 1 beta	Mus musculus	105-122
35046793-11	2021	Under low-glucose and hypoxic conditions, CGS21680 treatment promoted macrophage M2 polarization, increased the expression of PPARgamma, P65, and interleukin-10 (IL-10) and suppressed the expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta).	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	42-50	interleukin 1 beta	Mus musculus	246-263
35069768-8	2022	Additionally, the hippocampal cytokines interleukin-18 (IL-18) and interleukin-1 beta (IL-1beta) contents were reduced in the liquiritin-treated group.	liquiritin	126-136	interleukin 1 beta	Mus musculus	67-85
35006394-5	2022	RESULTS: Ex vivo imaging and endoscopy in L2-IL1B mice showed that the CXCR4-targeted MK007 accumulated mostly in the dysplastic lesions with a mean target-to-background ratio > 2.	mk007	86-91	interleukin 1 beta	Mus musculus	45-49
35237418-8	2022	ZOL upregulated the expression of interleukin-1beta, a proinflammatory cytokine.	tiletamine, zolazepam drug combination	0-3	interleukin 1 beta	Mus musculus	34-51