PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
15870270-0	2005	The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha.	Phosphatidylinositol 4,5-Diphosphate	32-69	ajuba LIM protein	Mus musculus	16-21
23105114-3	2012	Here, we show that the RA-induced commitment of P19 stem cells to neuronal progenitors is mediated by the CRABP-II/RAR path and that the FABP5/PPARbeta/delta path can inhibit the process through induction of the RAR repressors SIRT1 and Ajuba.	Tretinoin	23-25	ajuba LIM protein	Mus musculus	237-242
15870270-3	2005	Here we show that the LIM protein Ajuba contributes to the cellular regulation of PI(4,5)P2 levels by interacting with and activating the enzymatic activity of the PI(4)P 5-kinase (PIPKIalpha), the predominant enzyme in the synthesis of PI(4,5)P2, in a migration stimulus-regulated manner.	pi(4,5)p2	237-246	ajuba LIM protein	Mus musculus	34-39
15870270-4	2005	In migrating primary mouse embryonic fibroblasts (MEFs) from Ajuba(-/-) mice the level of PI(4,5)P2 was decreased with a corresponding increase in the level of the substrate PI(4)P.	(4,5)p2	92-99	ajuba LIM protein	Mus musculus	61-66
15870270-4	2005	In migrating primary mouse embryonic fibroblasts (MEFs) from Ajuba(-/-) mice the level of PI(4,5)P2 was decreased with a corresponding increase in the level of the substrate PI(4)P.	pi(4)p	174-180	ajuba LIM protein	Mus musculus	61-66
15870270-5	2005	Reintroduction of Ajuba into these cells normalized PI(4,5)P2 levels.	pi(4,5)p2	52-61	ajuba LIM protein	Mus musculus	18-23
15870270-6	2005	Localization of PI(4,5)P2 synthesis and PIPKIalpha in the leading lamellipodia and membrane ruffles, respectively, of migrating Ajuba(-/-) MEFs was impaired.	pi(4,5)p2	16-25	ajuba LIM protein	Mus musculus	128-133
15870270-6	2005	Localization of PI(4,5)P2 synthesis and PIPKIalpha in the leading lamellipodia and membrane ruffles, respectively, of migrating Ajuba(-/-) MEFs was impaired.	pipkialpha	40-50	ajuba LIM protein	Mus musculus	128-133
15870270-7	2005	In vitro, Ajuba dramatically activated the enzymatic activity of PIPKIalpha while inhibiting the activity of PIPKIIbeta.	pipkialpha	65-75	ajuba LIM protein	Mus musculus	10-15
15870270-8	2005	Thus, in addition to its effects upon Rac activity Ajuba can also influence cell migration through regulation of PI(4,5)P2 synthesis through direct activation of PIPKIalpha enzyme activity.	pi(4,5)p2	113-122	ajuba LIM protein	Mus musculus	51-56
15870270-3	2005	Here we show that the LIM protein Ajuba contributes to the cellular regulation of PI(4,5)P2 levels by interacting with and activating the enzymatic activity of the PI(4)P 5-kinase (PIPKIalpha), the predominant enzyme in the synthesis of PI(4,5)P2, in a migration stimulus-regulated manner.	pi(4,5)p2	82-91	ajuba LIM protein	Mus musculus	34-39