PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
12602512-4	2002	We have found that a cis-element for AP-1 binding is present in the enhancer region of the carbamoylphosphate synthetase (CPS) gene, and that the AP-1 binding site is involved in the suppression of CPS induction by dexamethasone in cultured hepatocytes and in the suppression of CPS expression in the liver of JVS mice.	Dexamethasone	215-228	carbamoyl-phosphate synthetase 1	Mus musculus	91-120
12602512-4	2002	We have found that a cis-element for AP-1 binding is present in the enhancer region of the carbamoylphosphate synthetase (CPS) gene, and that the AP-1 binding site is involved in the suppression of CPS induction by dexamethasone in cultured hepatocytes and in the suppression of CPS expression in the liver of JVS mice.	Dexamethasone	215-228	carbamoyl-phosphate synthetase 1	Mus musculus	122-125
12602512-4	2002	We have found that a cis-element for AP-1 binding is present in the enhancer region of the carbamoylphosphate synthetase (CPS) gene, and that the AP-1 binding site is involved in the suppression of CPS induction by dexamethasone in cultured hepatocytes and in the suppression of CPS expression in the liver of JVS mice.	Dexamethasone	215-228	carbamoyl-phosphate synthetase 1	Mus musculus	198-201
12602512-4	2002	We have found that a cis-element for AP-1 binding is present in the enhancer region of the carbamoylphosphate synthetase (CPS) gene, and that the AP-1 binding site is involved in the suppression of CPS induction by dexamethasone in cultured hepatocytes and in the suppression of CPS expression in the liver of JVS mice.	Dexamethasone	215-228	carbamoyl-phosphate synthetase 1	Mus musculus	198-201
11997094-6	2002	Citrin, ASS, CPS and Ornt1 showed similar patterns of developmental changes in the liver and small intestine, where they play a role in urea and arginine synthesis.	Urea	136-140	carbamoyl-phosphate synthetase 1	Mus musculus	13-16
11997094-6	2002	Citrin, ASS, CPS and Ornt1 showed similar patterns of developmental changes in the liver and small intestine, where they play a role in urea and arginine synthesis.	Arginine	145-153	carbamoyl-phosphate synthetase 1	Mus musculus	13-16
9862865-0	1999	Mice deficient in the urea-cycle enzyme, carbamoyl phosphate synthetase I, die during the early neonatal period from hyperammonemia.	Urea	22-26	carbamoyl-phosphate synthetase 1	Mus musculus	41-73
11136545-3	2000	We have found that all of the urea cycle enzyme genes are suppressed and that N-acetylglutamate, an allosteric activator of the first step enzyme of the urea cycle, carbamoyl phosphate synthetase I (CPS), is not deficient in the liver of JVS mice.	Urea	30-34	carbamoyl-phosphate synthetase 1	Mus musculus	199-202
11136545-3	2000	We have found that all of the urea cycle enzyme genes are suppressed and that N-acetylglutamate, an allosteric activator of the first step enzyme of the urea cycle, carbamoyl phosphate synthetase I (CPS), is not deficient in the liver of JVS mice.	N-acetylglutamic acid	78-95	carbamoyl-phosphate synthetase 1	Mus musculus	165-197
11136545-3	2000	We have found that all of the urea cycle enzyme genes are suppressed and that N-acetylglutamate, an allosteric activator of the first step enzyme of the urea cycle, carbamoyl phosphate synthetase I (CPS), is not deficient in the liver of JVS mice.	N-acetylglutamic acid	78-95	carbamoyl-phosphate synthetase 1	Mus musculus	199-202
11136545-3	2000	We have found that all of the urea cycle enzyme genes are suppressed and that N-acetylglutamate, an allosteric activator of the first step enzyme of the urea cycle, carbamoyl phosphate synthetase I (CPS), is not deficient in the liver of JVS mice.	Urea	153-157	carbamoyl-phosphate synthetase 1	Mus musculus	165-197
11136545-3	2000	We have found that all of the urea cycle enzyme genes are suppressed and that N-acetylglutamate, an allosteric activator of the first step enzyme of the urea cycle, carbamoyl phosphate synthetase I (CPS), is not deficient in the liver of JVS mice.	Urea	153-157	carbamoyl-phosphate synthetase 1	Mus musculus	199-202
9862865-3	1999	Carbamoyl phosphate synthetase I (CPSase I; EC 6.3.4.16) is located within the inner mitochondrial matrix and catalyzes the initial rate-limiting step of the urea cycle.	Urea	158-162	carbamoyl-phosphate synthetase 1	Mus musculus	0-32
9862865-3	1999	Carbamoyl phosphate synthetase I (CPSase I; EC 6.3.4.16) is located within the inner mitochondrial matrix and catalyzes the initial rate-limiting step of the urea cycle.	Urea	158-162	carbamoyl-phosphate synthetase 1	Mus musculus	34-42
9774647-1	1998	A single far-upstream enhancer is sufficient to confer hepatocyte-specific, glucocorticoid- and cyclic AMP-inducible periportal expression to the carbamoylphosphate synthetase I (CPS) gene.	Cyclic AMP	96-106	carbamoyl-phosphate synthetase 1	Mus musculus	146-177
9774647-1	1998	A single far-upstream enhancer is sufficient to confer hepatocyte-specific, glucocorticoid- and cyclic AMP-inducible periportal expression to the carbamoylphosphate synthetase I (CPS) gene.	Cyclic AMP	96-106	carbamoyl-phosphate synthetase 1	Mus musculus	179-182
8468725-4	1993	This stimulation with excess ammonia, which can also result from high-protein intake, is dependent on the presence of carbamoyl phosphate synthetase I, an enzyme in the liver and intestine but not in most tumors.	Ammonia	29-36	carbamoyl-phosphate synthetase 1	Mus musculus	118-150
8985169-2	1996	Addition of a synthetic glucocorticoid hormone, dexamethasone, caused increases in CPS and ASS mRNAs.	Dexamethasone	48-61	carbamoyl-phosphate synthetase 1	Mus musculus	83-86
8985169-3	1996	Further addition of oleic acid suppressed the induction of CPS and ASS mRNAs by dexamethasone.	Oleic Acid	20-30	carbamoyl-phosphate synthetase 1	Mus musculus	59-62
8985169-3	1996	Further addition of oleic acid suppressed the induction of CPS and ASS mRNAs by dexamethasone.	Dexamethasone	80-93	carbamoyl-phosphate synthetase 1	Mus musculus	59-62
8985169-7	1996	A study of the specificity of fatty acids revealed that long-chain fatty acids of more than 16 carbons chain length had a suppressive effect on the CPS mRNA level induced by dexamethasone and that the presence of double bonds enhanced the effect.	Fatty Acids	30-41	carbamoyl-phosphate synthetase 1	Mus musculus	148-151
8985169-7	1996	A study of the specificity of fatty acids revealed that long-chain fatty acids of more than 16 carbons chain length had a suppressive effect on the CPS mRNA level induced by dexamethasone and that the presence of double bonds enhanced the effect.	long-chain fatty acids	56-78	carbamoyl-phosphate synthetase 1	Mus musculus	148-151
8985169-7	1996	A study of the specificity of fatty acids revealed that long-chain fatty acids of more than 16 carbons chain length had a suppressive effect on the CPS mRNA level induced by dexamethasone and that the presence of double bonds enhanced the effect.	Carbon	95-102	carbamoyl-phosphate synthetase 1	Mus musculus	148-151
8985169-7	1996	A study of the specificity of fatty acids revealed that long-chain fatty acids of more than 16 carbons chain length had a suppressive effect on the CPS mRNA level induced by dexamethasone and that the presence of double bonds enhanced the effect.	Dexamethasone	174-187	carbamoyl-phosphate synthetase 1	Mus musculus	148-151
8985169-8	1996	The changes in gene expression of CPS, ASS and PEPCK caused by the fatty acids in the cultured hepatocytes were very similar to those observed in the liver of JVS mice.	Fatty Acids	67-78	carbamoyl-phosphate synthetase 1	Mus musculus	34-37
8940127-1	1996	The carbamoyl-phosphate synthetase I gene is expressed in the periportal region of the liver, where it is activated by glucocorticosteroids and glucagon (via cyclic AMP), and in the crypts of the intestinal mucosa.	Cyclic AMP	158-168	carbamoyl-phosphate synthetase 1	Mus musculus	4-36
8733888-6	1996	In SCAD-deficient mice we found depressed mRNA expression and enzyme activity for the urea cycle enzymes CPS and AS at 6 days of age, and found no apparent effects on expression of gluconeogenic enzymes PC or PEPCK.	Urea	86-90	carbamoyl-phosphate synthetase 1	Mus musculus	105-108
8921583-6	1996	Dexamethasone stimulated hepatocyte differentiation (expression of CPSI and glycogen accumulation) and large lumen formation of hepatocytes, but it did not change the commencement of differentiation.	Dexamethasone	0-13	carbamoyl-phosphate synthetase 1	Mus musculus	67-71
8468725-14	1993	CONCLUSIONS: We propose that the basis for these effects of a high-protein diet is the generation of excess carbamoyl phosphate in tissues containing carbamoyl phosphate synthetase I.	Carbamyl Phosphate	108-127	carbamoyl-phosphate synthetase 1	Mus musculus	150-182
1828177-0	1991	Inhibition of carbamoyl phosphate synthetase-I by dietary dehydroepiandrosterone.	Dehydroepiandrosterone	58-80	carbamoyl-phosphate synthetase 1	Mus musculus	14-46
1828177-7	1991	A protein of Mr approximately 160 K, which was identified as carbamoyl phosphate synthetase-I (CPS-I), was decreased markedly by DHEA action.	Dehydroepiandrosterone	129-133	carbamoyl-phosphate synthetase 1	Mus musculus	61-93
1828177-7	1991	A protein of Mr approximately 160 K, which was identified as carbamoyl phosphate synthetase-I (CPS-I), was decreased markedly by DHEA action.	Dehydroepiandrosterone	129-133	carbamoyl-phosphate synthetase 1	Mus musculus	95-100
1828177-10	1991	The specific activity of CPS-I also was significantly decreased by DHEA, but serum urea levels were normal.	Dehydroepiandrosterone	67-71	carbamoyl-phosphate synthetase 1	Mus musculus	25-30
1828177-12	1991	The findings of this study serve to demonstrate that: (i) hepatic protein levels are affected by DHEA treatment of mice and rats; (ii) liver CPS-I activity is decreased significantly by DHEA treatment, but serum urea levels remain within the normal range; and (iii) sex steroids and some of their precursors, when administered per os, also alter liver protein levels.	Dehydroepiandrosterone	186-190	carbamoyl-phosphate synthetase 1	Mus musculus	141-146
1828177-12	1991	The findings of this study serve to demonstrate that: (i) hepatic protein levels are affected by DHEA treatment of mice and rats; (ii) liver CPS-I activity is decreased significantly by DHEA treatment, but serum urea levels remain within the normal range; and (iii) sex steroids and some of their precursors, when administered per os, also alter liver protein levels.	Steroids	270-278	carbamoyl-phosphate synthetase 1	Mus musculus	141-146
35202247-7	2022	FMO3-deficient mice showed hepatic overexpression of carbamoylphosphate synthetase (CPS1), the rate-limiting gene of urea cycle, and increased hepatic urea levels, especially in mice of FVB (Friend leukemia virus B strain) background.	Urea	117-121	carbamoyl-phosphate synthetase 1	Mus musculus	84-88
35285892-0	2022	Regulation of the urea cycle by CPS1 O-GlcNAcylation in response to dietary restriction and aging.	Urea	18-22	carbamoyl-phosphate synthetase 1	Mus musculus	32-36
35285892-5	2022	CPS1 O-GlcNAcylation is reversed by calorie restriction and is sensitive to genetic and pharmacological manipulations of the O-GlcNAc pathway.	o-glcnac	125-133	carbamoyl-phosphate synthetase 1	Mus musculus	0-4
35285892-6	2022	High glucose stimulates CPS1 O-GlcNAcylation and inhibits CPS1 activity.	Glucose	5-12	carbamoyl-phosphate synthetase 1	Mus musculus	58-62
35285892-8	2022	Our results identify CPS1 O-GlcNAcylation as a key nutrient-sensing regulatory step in the urea cycle during aging and dietary restriction, implying a role for mitochondrial O-GlcNAcylation in nutritional regulation of longevity.	Urea	91-95	carbamoyl-phosphate synthetase 1	Mus musculus	21-25
35232986-7	2022	CPS1 hepatic expression was diminished in parallel with the increase of fibrosis, and its levels reverted up to normality after changing diet in CDA-HFD mice.	Cladribine	145-148	carbamoyl-phosphate synthetase 1	Mus musculus	0-4
33807173-7	2021	TMP significantly down-regulated KHK, GLO1, ATP5H, SOD, and DDAH1 and up-regulated DLD, Mup1, CPS1, Ces3b, PDI, and HYOU1 compared to the HFD-SP group.	Thymidine Monophosphate	0-3	carbamoyl-phosphate synthetase 1	Mus musculus	94-98
35038468-7	2022	Compared with WL-CPS-1, GLU-CPS-1 exhibited higher in vivo activity and enriched Odoribacter and Alloprevotella correlating with the gene expression of lipid metabolism, suggesting that the bioactivity of polysaccharides could be regulated by culture conditions.	Polysaccharides	205-220	carbamoyl-phosphate synthetase 1	Mus musculus	28-33
32359471-1	2020	The urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) catalyzes the initial step of the urea cycle; bi-allelic mutations typically present with hyperammonemia, vomiting, ataxia, lethargy progressing into coma, and death due to brain edema if ineffectively treated.	Urea	4-8	carbamoyl-phosphate synthetase 1	Mus musculus	22-54
6825836-2	1983	N-Acetyl-L-glutamate synthetase catalyzes the synthesis of N-acetyl-L-glutamate, an allosteric and essential activator of carbamoyl-phosphate synthetase I in the liver of ureotelic animals.	N-acetylglutamic acid	59-79	carbamoyl-phosphate synthetase 1	Mus musculus	122-154
32359471-1	2020	The urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) catalyzes the initial step of the urea cycle; bi-allelic mutations typically present with hyperammonemia, vomiting, ataxia, lethargy progressing into coma, and death due to brain edema if ineffectively treated.	Urea	4-8	carbamoyl-phosphate synthetase 1	Mus musculus	56-60
32359471-1	2020	The urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) catalyzes the initial step of the urea cycle; bi-allelic mutations typically present with hyperammonemia, vomiting, ataxia, lethargy progressing into coma, and death due to brain edema if ineffectively treated.	Urea	96-100	carbamoyl-phosphate synthetase 1	Mus musculus	22-54
32359471-1	2020	The urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) catalyzes the initial step of the urea cycle; bi-allelic mutations typically present with hyperammonemia, vomiting, ataxia, lethargy progressing into coma, and death due to brain edema if ineffectively treated.	Urea	96-100	carbamoyl-phosphate synthetase 1	Mus musculus	56-60
32359471-6	2020	Cps1-deficient mice treated with sAAVs survive long-term with markedly improved ammonia levels, diminished dysregulation of circulating amino acids, and increased hepatic CPS1 expression and activity.	Ammonia	80-87	carbamoyl-phosphate synthetase 1	Mus musculus	0-4
32359471-8	2020	This study demonstrates the first proof-of-principle that sAAV-mediated therapy is a viable, potentially clinically translatable approach to CPS1 deficiency, a devastating urea cycle disorder.	Urea	172-176	carbamoyl-phosphate synthetase 1	Mus musculus	141-145
26075008-0	2015	Ammonia-lowering activities and carbamoyl phosphate synthetase 1 (Cps1) induction mechanism of a natural flavonoid.	Flavonoids	105-114	carbamoyl-phosphate synthetase 1	Mus musculus	32-64
31016736-10	2019	Of urea cycle-related genes, arginase 1 (Arg1), ornithine transcarbamylase (Otc), and carbamoyl-phosphate synthase 1 (Cps1) expressions were up-regulated in Rev-erbalpha-/- mice.	Urea	3-7	carbamoyl-phosphate synthetase 1	Mus musculus	86-116
31016736-10	2019	Of urea cycle-related genes, arginase 1 (Arg1), ornithine transcarbamylase (Otc), and carbamoyl-phosphate synthase 1 (Cps1) expressions were up-regulated in Rev-erbalpha-/- mice.	Urea	3-7	carbamoyl-phosphate synthetase 1	Mus musculus	118-122
30843237-2	2019	When compared with mice that are highly repopulated with CPS1-proficient human hepatocytes, mice that are repopulated with CPS1-deficient human hepatocytes exhibited characteristic symptoms of human CPS1 deficiency including an 80% reduction in CPS1 metabolic activity, delayed clearance of an ammonium chloride infusion, elevated glutamine and glutamate levels, and impaired metabolism of [15 N]ammonium chloride into urea, with no other obvious phenotypic differences.	Glutamine	331-340	carbamoyl-phosphate synthetase 1	Mus musculus	123-127
30843237-2	2019	When compared with mice that are highly repopulated with CPS1-proficient human hepatocytes, mice that are repopulated with CPS1-deficient human hepatocytes exhibited characteristic symptoms of human CPS1 deficiency including an 80% reduction in CPS1 metabolic activity, delayed clearance of an ammonium chloride infusion, elevated glutamine and glutamate levels, and impaired metabolism of [15 N]ammonium chloride into urea, with no other obvious phenotypic differences.	Glutamic Acid	345-354	carbamoyl-phosphate synthetase 1	Mus musculus	123-127
30843237-2	2019	When compared with mice that are highly repopulated with CPS1-proficient human hepatocytes, mice that are repopulated with CPS1-deficient human hepatocytes exhibited characteristic symptoms of human CPS1 deficiency including an 80% reduction in CPS1 metabolic activity, delayed clearance of an ammonium chloride infusion, elevated glutamine and glutamate levels, and impaired metabolism of [15 N]ammonium chloride into urea, with no other obvious phenotypic differences.	Ammonium Chloride	396-413	carbamoyl-phosphate synthetase 1	Mus musculus	123-127
30843237-2	2019	When compared with mice that are highly repopulated with CPS1-proficient human hepatocytes, mice that are repopulated with CPS1-deficient human hepatocytes exhibited characteristic symptoms of human CPS1 deficiency including an 80% reduction in CPS1 metabolic activity, delayed clearance of an ammonium chloride infusion, elevated glutamine and glutamate levels, and impaired metabolism of [15 N]ammonium chloride into urea, with no other obvious phenotypic differences.	Urea	419-423	carbamoyl-phosphate synthetase 1	Mus musculus	123-127
30979808-1	2019	Carbamoyl phosphate synthetase-1 (CPS1) is the major mitochondrial urea cycle enzyme in hepatocytes.	Urea	67-71	carbamoyl-phosphate synthetase 1	Mus musculus	0-32
30979808-1	2019	Carbamoyl phosphate synthetase-1 (CPS1) is the major mitochondrial urea cycle enzyme in hepatocytes.	Urea	67-71	carbamoyl-phosphate synthetase 1	Mus musculus	34-38
29801986-1	2018	Carbamoyl phosphate synthetase 1 (CPS1) is a urea cycle enzyme that forms carbamoyl phosphate from bicarbonate, ammonia and ATP.	Urea	45-49	carbamoyl-phosphate synthetase 1	Mus musculus	0-32
29801986-1	2018	Carbamoyl phosphate synthetase 1 (CPS1) is a urea cycle enzyme that forms carbamoyl phosphate from bicarbonate, ammonia and ATP.	Urea	45-49	carbamoyl-phosphate synthetase 1	Mus musculus	34-38
29801986-1	2018	Carbamoyl phosphate synthetase 1 (CPS1) is a urea cycle enzyme that forms carbamoyl phosphate from bicarbonate, ammonia and ATP.	Carbamyl Phosphate	74-93	carbamoyl-phosphate synthetase 1	Mus musculus	0-32
29801986-1	2018	Carbamoyl phosphate synthetase 1 (CPS1) is a urea cycle enzyme that forms carbamoyl phosphate from bicarbonate, ammonia and ATP.	Carbamyl Phosphate	74-93	carbamoyl-phosphate synthetase 1	Mus musculus	34-38
29801986-1	2018	Carbamoyl phosphate synthetase 1 (CPS1) is a urea cycle enzyme that forms carbamoyl phosphate from bicarbonate, ammonia and ATP.	Bicarbonates	99-110	carbamoyl-phosphate synthetase 1	Mus musculus	0-32
29801986-1	2018	Carbamoyl phosphate synthetase 1 (CPS1) is a urea cycle enzyme that forms carbamoyl phosphate from bicarbonate, ammonia and ATP.	Bicarbonates	99-110	carbamoyl-phosphate synthetase 1	Mus musculus	34-38
29801986-1	2018	Carbamoyl phosphate synthetase 1 (CPS1) is a urea cycle enzyme that forms carbamoyl phosphate from bicarbonate, ammonia and ATP.	Ammonia	112-119	carbamoyl-phosphate synthetase 1	Mus musculus	0-32
29801986-1	2018	Carbamoyl phosphate synthetase 1 (CPS1) is a urea cycle enzyme that forms carbamoyl phosphate from bicarbonate, ammonia and ATP.	Ammonia	112-119	carbamoyl-phosphate synthetase 1	Mus musculus	34-38
29801986-1	2018	Carbamoyl phosphate synthetase 1 (CPS1) is a urea cycle enzyme that forms carbamoyl phosphate from bicarbonate, ammonia and ATP.	Adenosine Triphosphate	124-127	carbamoyl-phosphate synthetase 1	Mus musculus	0-32
29801986-1	2018	Carbamoyl phosphate synthetase 1 (CPS1) is a urea cycle enzyme that forms carbamoyl phosphate from bicarbonate, ammonia and ATP.	Adenosine Triphosphate	124-127	carbamoyl-phosphate synthetase 1	Mus musculus	34-38
29801986-2	2018	Bi-allelic mutations of the CPS1 gene result in a urea cycle disorder presenting with hyperammonemia, often with reduced citrulline, and without orotic aciduria.	Citrulline	121-131	carbamoyl-phosphate synthetase 1	Mus musculus	28-32
29426940-3	2018	In normal development, the ammonia metabolising enzymes carbamoylphosphate synthetase I (CPSI) and Glutamine synthetase (GS) begin to be expressed in separate hepatoblasts from E13.5 and E15.5 respectively and gradually increase in number thereafter.	Ammonia	27-34	carbamoyl-phosphate synthetase 1	Mus musculus	56-87
29426940-3	2018	In normal development, the ammonia metabolising enzymes carbamoylphosphate synthetase I (CPSI) and Glutamine synthetase (GS) begin to be expressed in separate hepatoblasts from E13.5 and E15.5 respectively and gradually increase in number thereafter.	Ammonia	27-34	carbamoyl-phosphate synthetase 1	Mus musculus	89-93
30549841-6	2017	Furthermore, the mRNA expression levels of carbamoyl phosphate synthetase 1 (Cpsl) and arginase I (Argl), in the urea cycle, were increased by OM-X  feeding.	Urea	113-117	carbamoyl-phosphate synthetase 1	Mus musculus	43-75
27052737-5	2016	Glucagon significantly stimulated ureagenesis, expression of SIRT3, SIRT5 and the activities of CPS1 and OCT but did not stimulate PGC-1alpha silencing hepatocytes in mice periportal hepatocytes.	Glucagon	0-8	carbamoyl-phosphate synthetase 1	Mus musculus	96-100
26934552-4	2016	Furthermore, portal/periportal induction of the rate limiting enzyme in ammonia detoxification, i.e. carbamoyl phosphate synthetase 1 was observed.	Ammonia	72-79	carbamoyl-phosphate synthetase 1	Mus musculus	101-133
30714172-7	2019	A parallel pattern was observed for carbamoylphosphate synthetase 1 and OTC enzyme expression and activities, which may act as pacemaker of this ammonia detoxification pathway.	Ammonia	145-152	carbamoyl-phosphate synthetase 1	Mus musculus	36-67
30724386-6	2019	In summary, we found that upregulation of hepatic GS reduced hyperammonemia in wild-type and Cps1-deficient mice, thus confirming a key role of GS in ammonia detoxification.	Ammonia	150-157	carbamoyl-phosphate synthetase 1	Mus musculus	93-97
30835861-1	2019	The enzyme carbamoyl phosphate synthetase 1 (CPS1; EC 6.3.4.16) forms carbamoyl phosphate from bicarbonate, ammonia, and adenosine triphosphate (ATP) and is activated allosterically by N-acetylglutamate.	Carbamyl Phosphate	11-30	carbamoyl-phosphate synthetase 1	Mus musculus	45-49
30835861-1	2019	The enzyme carbamoyl phosphate synthetase 1 (CPS1; EC 6.3.4.16) forms carbamoyl phosphate from bicarbonate, ammonia, and adenosine triphosphate (ATP) and is activated allosterically by N-acetylglutamate.	Bicarbonates	95-106	carbamoyl-phosphate synthetase 1	Mus musculus	11-43
30835861-1	2019	The enzyme carbamoyl phosphate synthetase 1 (CPS1; EC 6.3.4.16) forms carbamoyl phosphate from bicarbonate, ammonia, and adenosine triphosphate (ATP) and is activated allosterically by N-acetylglutamate.	Bicarbonates	95-106	carbamoyl-phosphate synthetase 1	Mus musculus	45-49
30835861-1	2019	The enzyme carbamoyl phosphate synthetase 1 (CPS1; EC 6.3.4.16) forms carbamoyl phosphate from bicarbonate, ammonia, and adenosine triphosphate (ATP) and is activated allosterically by N-acetylglutamate.	Ammonia	108-115	carbamoyl-phosphate synthetase 1	Mus musculus	11-43
30835861-1	2019	The enzyme carbamoyl phosphate synthetase 1 (CPS1; EC 6.3.4.16) forms carbamoyl phosphate from bicarbonate, ammonia, and adenosine triphosphate (ATP) and is activated allosterically by N-acetylglutamate.	Ammonia	108-115	carbamoyl-phosphate synthetase 1	Mus musculus	45-49
30835861-1	2019	The enzyme carbamoyl phosphate synthetase 1 (CPS1; EC 6.3.4.16) forms carbamoyl phosphate from bicarbonate, ammonia, and adenosine triphosphate (ATP) and is activated allosterically by N-acetylglutamate.	Adenosine	121-130	carbamoyl-phosphate synthetase 1	Mus musculus	11-43
30835861-1	2019	The enzyme carbamoyl phosphate synthetase 1 (CPS1; EC 6.3.4.16) forms carbamoyl phosphate from bicarbonate, ammonia, and adenosine triphosphate (ATP) and is activated allosterically by N-acetylglutamate.	Adenosine	121-130	carbamoyl-phosphate synthetase 1	Mus musculus	45-49
30835861-1	2019	The enzyme carbamoyl phosphate synthetase 1 (CPS1; EC 6.3.4.16) forms carbamoyl phosphate from bicarbonate, ammonia, and adenosine triphosphate (ATP) and is activated allosterically by N-acetylglutamate.	Adenosine Triphosphate	145-148	carbamoyl-phosphate synthetase 1	Mus musculus	11-43
30835861-1	2019	The enzyme carbamoyl phosphate synthetase 1 (CPS1; EC 6.3.4.16) forms carbamoyl phosphate from bicarbonate, ammonia, and adenosine triphosphate (ATP) and is activated allosterically by N-acetylglutamate.	Adenosine Triphosphate	145-148	carbamoyl-phosphate synthetase 1	Mus musculus	45-49
30835861-1	2019	The enzyme carbamoyl phosphate synthetase 1 (CPS1; EC 6.3.4.16) forms carbamoyl phosphate from bicarbonate, ammonia, and adenosine triphosphate (ATP) and is activated allosterically by N-acetylglutamate.	N-acetylglutamic acid	185-202	carbamoyl-phosphate synthetase 1	Mus musculus	11-43
30835861-1	2019	The enzyme carbamoyl phosphate synthetase 1 (CPS1; EC 6.3.4.16) forms carbamoyl phosphate from bicarbonate, ammonia, and adenosine triphosphate (ATP) and is activated allosterically by N-acetylglutamate.	N-acetylglutamic acid	185-202	carbamoyl-phosphate synthetase 1	Mus musculus	45-49
30835861-2	2019	The neonatal presentation of bi-allelic mutations of CPS1 results in hyperammonemia with reduced citrulline and is reported as the most challenging nitrogen metabolism disorder to treat.	Citrulline	97-107	carbamoyl-phosphate synthetase 1	Mus musculus	53-57
30835861-2	2019	The neonatal presentation of bi-allelic mutations of CPS1 results in hyperammonemia with reduced citrulline and is reported as the most challenging nitrogen metabolism disorder to treat.	Nitrogen	148-156	carbamoyl-phosphate synthetase 1	Mus musculus	53-57
30843237-2	2019	When compared with mice that are highly repopulated with CPS1-proficient human hepatocytes, mice that are repopulated with CPS1-deficient human hepatocytes exhibited characteristic symptoms of human CPS1 deficiency including an 80% reduction in CPS1 metabolic activity, delayed clearance of an ammonium chloride infusion, elevated glutamine and glutamate levels, and impaired metabolism of [15 N]ammonium chloride into urea, with no other obvious phenotypic differences.	Ammonium Chloride	294-311	carbamoyl-phosphate synthetase 1	Mus musculus	123-127
30865431-6	2019	Like PFOA, 10 mg/kg/d of PFO4DA decreased the urea cycle-related enzyme protein levels (e.g., carbamoyl phosphate synthetase 1) and serum ammonia content in a dose-dependent manner.	Perfluoro-3,5,7,9-butaoxadecanoic acid	25-31	carbamoyl-phosphate synthetase 1	Mus musculus	94-126
30865431-6	2019	Like PFOA, 10 mg/kg/d of PFO4DA decreased the urea cycle-related enzyme protein levels (e.g., carbamoyl phosphate synthetase 1) and serum ammonia content in a dose-dependent manner.	Urea	46-50	carbamoyl-phosphate synthetase 1	Mus musculus	94-126
26075008-0	2015	Ammonia-lowering activities and carbamoyl phosphate synthetase 1 (Cps1) induction mechanism of a natural flavonoid.	Flavonoids	105-114	carbamoyl-phosphate synthetase 1	Mus musculus	66-70
26075008-8	2015	A circadian clock-deficient mouse mutant, Clock (Delta19/Delta19) , was utilized to examine a requisite role of the circadian clock in mediating NOB induction of Cps1.	nobiletin	145-148	carbamoyl-phosphate synthetase 1	Mus musculus	162-166
26075008-10	2015	Compared with RC, HFD repressed the mRNA and protein expression of Cps1, encoding the rate-limiting enzyme of the urea cycle.	Urea	114-118	carbamoyl-phosphate synthetase 1	Mus musculus	67-71
26075008-12	2015	Expression of other urea cycle genes was also decreased by HFD relative to RC and again restored by NOB to varying degrees, which, in conjunction with Cps1 promoter reporter analysis, suggested a C/EBP-dependent mechanism for the co-induction of urea cycle genes by NOB.	Urea	20-24	carbamoyl-phosphate synthetase 1	Mus musculus	151-155
22753949-4	2012	CPS specifically increased Atg4C mRNA expression and induced oxidation of Atg4C protein by ROS generation.	ros	91-94	carbamoyl-phosphate synthetase 1	Mus musculus	0-3
24924744-5	2014	CPS1 was also detected in mouse serum upon acute challenge with Fas-ligand or acetaminophen and in hepatocytes upon hypoosmotic stress, independent of hepatocyte caspase activation.	ammonium ferrous sulfate	64-67	carbamoyl-phosphate synthetase 1	Mus musculus	0-4
24924744-5	2014	CPS1 was also detected in mouse serum upon acute challenge with Fas-ligand or acetaminophen and in hepatocytes upon hypoosmotic stress, independent of hepatocyte caspase activation.	Acetaminophen	78-91	carbamoyl-phosphate synthetase 1	Mus musculus	0-4
24924744-6	2014	Furthermore, CPS1 was observed in sera of mice chronically fed the hepatotoxin 3,5-diethoxycarbonyl-1,4-dihydrocollidine.	3,5-diethoxycarbonyl-1,4-dihydrocollidine	79-120	carbamoyl-phosphate synthetase 1	Mus musculus	13-17
25684186-9	2015	Analysis of the liver proteome of 4-week ethanol-fed rats and PIMT KO mice demonstrated elevated cytosolic CPS-1 and betaine homocysteine S-methyltransferase-1 when compared to their respective controls, and a significant reduction of carbonic anhydrase-III (CA-III) evident only in ethanol-fed rats.	Ethanol	41-48	carbamoyl-phosphate synthetase 1	Mus musculus	107-112
24703693-5	2014	We validated carbamoyl phosphate synthase 1 (CPS1), the rate-limiting enzyme in urea cycle, as a glutarylated protein and demonstrated that CPS1 is targeted by SIRT5 for deglutarylation.	Urea	80-84	carbamoyl-phosphate synthetase 1	Mus musculus	13-43
24703693-5	2014	We validated carbamoyl phosphate synthase 1 (CPS1), the rate-limiting enzyme in urea cycle, as a glutarylated protein and demonstrated that CPS1 is targeted by SIRT5 for deglutarylation.	Urea	80-84	carbamoyl-phosphate synthetase 1	Mus musculus	45-49
24703693-5	2014	We validated carbamoyl phosphate synthase 1 (CPS1), the rate-limiting enzyme in urea cycle, as a glutarylated protein and demonstrated that CPS1 is targeted by SIRT5 for deglutarylation.	Urea	80-84	carbamoyl-phosphate synthetase 1	Mus musculus	140-144
24703693-6	2014	We further showed that glutarylation suppresses CPS1 enzymatic activity in cell lines, mice, and a model of glutaric acidemia type I disease, the last of which has elevated glutaric acid and glutaryl-CoA.	glutaric acid	108-121	carbamoyl-phosphate synthetase 1	Mus musculus	48-52
24703693-6	2014	We further showed that glutarylation suppresses CPS1 enzymatic activity in cell lines, mice, and a model of glutaric acidemia type I disease, the last of which has elevated glutaric acid and glutaryl-CoA.	glutaryl-coenzyme A	191-203	carbamoyl-phosphate synthetase 1	Mus musculus	48-52
22753949-8	2012	Interestingly, we found that CPS induces autophagy of DP(dull) cells, and inhibition of CPS-induced autophagy by the 3-MA autophagic inhibitor induces apoptosis of DP(dull) cells, suggesting the presence of an interplay between autophagic survival and apoptotic cell death.	dp	54-56	carbamoyl-phosphate synthetase 1	Mus musculus	29-32
22753949-8	2012	Interestingly, we found that CPS induces autophagy of DP(dull) cells, and inhibition of CPS-induced autophagy by the 3-MA autophagic inhibitor induces apoptosis of DP(dull) cells, suggesting the presence of an interplay between autophagic survival and apoptotic cell death.	dp	164-166	carbamoyl-phosphate synthetase 1	Mus musculus	88-91
21540182-2	2011	Here, we demonstrate that IBMX and other oxypurines containing a 2,6-dione group interfere with the binding of glutamate to the active site of N-acetylglutamate synthetase (NAGS), thereby decreasing synthesis of N-acetylglutamate, the obligatory activator of carbamoyl phosphate synthase-1 (CPS1).	1-Methyl-3-isobutylxanthine	26-30	carbamoyl-phosphate synthetase 1	Mus musculus	259-289
22593623-3	2012	The mCPS total score was reliably related to high externalizing problems, low empathy, high anger and aggression, high impulsivity, high (violent) delinquency, and high alcohol/drug use.	Alcohols	169-176	carbamoyl-phosphate synthetase 1	Mus musculus	4-8
22402285-0	2012	Protein tyrosine nitration of mitochondrial carbamoyl phosphate synthetase 1 and its functional consequences.	Tyrosine	8-16	carbamoyl-phosphate synthetase 1	Mus musculus	44-76
22402285-5	2012	One of the major proteins nitrated by peroxynitrite was carbamoyl phosphate synthetase 1 (CPS1) as identified by LC-MS protein analysis and Western blotting.	Peroxynitrous Acid	38-51	carbamoyl-phosphate synthetase 1	Mus musculus	56-88
22402285-5	2012	One of the major proteins nitrated by peroxynitrite was carbamoyl phosphate synthetase 1 (CPS1) as identified by LC-MS protein analysis and Western blotting.	Peroxynitrous Acid	38-51	carbamoyl-phosphate synthetase 1	Mus musculus	90-94
22402285-6	2012	The band intensity of nitration normalized to CPS1 was increased in a peroxynitrite concentration-dependent manner.	Peroxynitrous Acid	70-83	carbamoyl-phosphate synthetase 1	Mus musculus	46-50
22402285-7	2012	In addition, CPS1 activity was decreased by treatment with peroxynitrite in a peroxynitrite concentration- and time-dependent manner.	Peroxynitrous Acid	59-72	carbamoyl-phosphate synthetase 1	Mus musculus	13-17
22402285-7	2012	In addition, CPS1 activity was decreased by treatment with peroxynitrite in a peroxynitrite concentration- and time-dependent manner.	Peroxynitrous Acid	78-91	carbamoyl-phosphate synthetase 1	Mus musculus	13-17
22402285-8	2012	The decreased CPS1 activity was not recovered by treatment with reduced glutathione, suggesting that the decrease of the CPS1 activity is due to tyrosine nitration rather than cysteine oxidation.	Glutathione	72-83	carbamoyl-phosphate synthetase 1	Mus musculus	121-125
22402285-8	2012	The decreased CPS1 activity was not recovered by treatment with reduced glutathione, suggesting that the decrease of the CPS1 activity is due to tyrosine nitration rather than cysteine oxidation.	Tyrosine	145-153	carbamoyl-phosphate synthetase 1	Mus musculus	14-18
22402285-8	2012	The decreased CPS1 activity was not recovered by treatment with reduced glutathione, suggesting that the decrease of the CPS1 activity is due to tyrosine nitration rather than cysteine oxidation.	Tyrosine	145-153	carbamoyl-phosphate synthetase 1	Mus musculus	121-125
22402285-9	2012	LC-MS analysis of in-gel digested samples, and a Popitam-based modification search located 5 out of 36 tyrosine residues in CPS1 that were nitrated.	Tyrosine	103-111	carbamoyl-phosphate synthetase 1	Mus musculus	124-128
22402285-10	2012	Taken together with previous findings regarding CPS1 structure and function, homology modeling of mouse CPS1 suggested that nitration at Y1450 in an alpha-helix of allosteric domain prevents activation of CPS1 by its activator, N-acetyl-l-glutamate.	N-acetylglutamic acid	228-248	carbamoyl-phosphate synthetase 1	Mus musculus	104-108
22402285-10	2012	Taken together with previous findings regarding CPS1 structure and function, homology modeling of mouse CPS1 suggested that nitration at Y1450 in an alpha-helix of allosteric domain prevents activation of CPS1 by its activator, N-acetyl-l-glutamate.	N-acetylglutamic acid	228-248	carbamoyl-phosphate synthetase 1	Mus musculus	104-108
22402285-11	2012	In conclusion, this study demonstrated the tyrosine nitration of CPS1 by peroxynitrite and its functional consequence.	Tyrosine	43-51	carbamoyl-phosphate synthetase 1	Mus musculus	65-69
22402285-11	2012	In conclusion, this study demonstrated the tyrosine nitration of CPS1 by peroxynitrite and its functional consequence.	Peroxynitrous Acid	73-86	carbamoyl-phosphate synthetase 1	Mus musculus	65-69
22402285-12	2012	Since CPS1 is responsible for ammonia removal in the urea cycle, nitration of CPS1 with attenuated function might be involved in some diseases and drug-induced toxicities associated with mitochondrial dysfunction.	Ammonia	30-37	carbamoyl-phosphate synthetase 1	Mus musculus	6-10
22402285-12	2012	Since CPS1 is responsible for ammonia removal in the urea cycle, nitration of CPS1 with attenuated function might be involved in some diseases and drug-induced toxicities associated with mitochondrial dysfunction.	Urea	53-57	carbamoyl-phosphate synthetase 1	Mus musculus	6-10
22402285-12	2012	Since CPS1 is responsible for ammonia removal in the urea cycle, nitration of CPS1 with attenuated function might be involved in some diseases and drug-induced toxicities associated with mitochondrial dysfunction.	Urea	53-57	carbamoyl-phosphate synthetase 1	Mus musculus	78-82
21540182-2	2011	Here, we demonstrate that IBMX and other oxypurines containing a 2,6-dione group interfere with the binding of glutamate to the active site of N-acetylglutamate synthetase (NAGS), thereby decreasing synthesis of N-acetylglutamate, the obligatory activator of carbamoyl phosphate synthase-1 (CPS1).	1-Methyl-3-isobutylxanthine	26-30	carbamoyl-phosphate synthetase 1	Mus musculus	291-295
21540182-2	2011	Here, we demonstrate that IBMX and other oxypurines containing a 2,6-dione group interfere with the binding of glutamate to the active site of N-acetylglutamate synthetase (NAGS), thereby decreasing synthesis of N-acetylglutamate, the obligatory activator of carbamoyl phosphate synthase-1 (CPS1).	oxypurines	41-51	carbamoyl-phosphate synthetase 1	Mus musculus	259-289
21540182-2	2011	Here, we demonstrate that IBMX and other oxypurines containing a 2,6-dione group interfere with the binding of glutamate to the active site of N-acetylglutamate synthetase (NAGS), thereby decreasing synthesis of N-acetylglutamate, the obligatory activator of carbamoyl phosphate synthase-1 (CPS1).	oxypurines	41-51	carbamoyl-phosphate synthetase 1	Mus musculus	291-295
21540182-2	2011	Here, we demonstrate that IBMX and other oxypurines containing a 2,6-dione group interfere with the binding of glutamate to the active site of N-acetylglutamate synthetase (NAGS), thereby decreasing synthesis of N-acetylglutamate, the obligatory activator of carbamoyl phosphate synthase-1 (CPS1).	2,2-Dimethyl-1,3-dioxane-4,6-dione	65-74	carbamoyl-phosphate synthetase 1	Mus musculus	259-289
21540182-2	2011	Here, we demonstrate that IBMX and other oxypurines containing a 2,6-dione group interfere with the binding of glutamate to the active site of N-acetylglutamate synthetase (NAGS), thereby decreasing synthesis of N-acetylglutamate, the obligatory activator of carbamoyl phosphate synthase-1 (CPS1).	2,2-Dimethyl-1,3-dioxane-4,6-dione	65-74	carbamoyl-phosphate synthetase 1	Mus musculus	291-295
21540182-2	2011	Here, we demonstrate that IBMX and other oxypurines containing a 2,6-dione group interfere with the binding of glutamate to the active site of N-acetylglutamate synthetase (NAGS), thereby decreasing synthesis of N-acetylglutamate, the obligatory activator of carbamoyl phosphate synthase-1 (CPS1).	Glutamic Acid	111-120	carbamoyl-phosphate synthetase 1	Mus musculus	259-289
21540182-2	2011	Here, we demonstrate that IBMX and other oxypurines containing a 2,6-dione group interfere with the binding of glutamate to the active site of N-acetylglutamate synthetase (NAGS), thereby decreasing synthesis of N-acetylglutamate, the obligatory activator of carbamoyl phosphate synthase-1 (CPS1).	Glutamic Acid	111-120	carbamoyl-phosphate synthetase 1	Mus musculus	291-295
21540182-2	2011	Here, we demonstrate that IBMX and other oxypurines containing a 2,6-dione group interfere with the binding of glutamate to the active site of N-acetylglutamate synthetase (NAGS), thereby decreasing synthesis of N-acetylglutamate, the obligatory activator of carbamoyl phosphate synthase-1 (CPS1).	N-acetylglutamic acid	143-160	carbamoyl-phosphate synthetase 1	Mus musculus	259-289
21540182-2	2011	Here, we demonstrate that IBMX and other oxypurines containing a 2,6-dione group interfere with the binding of glutamate to the active site of N-acetylglutamate synthetase (NAGS), thereby decreasing synthesis of N-acetylglutamate, the obligatory activator of carbamoyl phosphate synthase-1 (CPS1).	N-acetylglutamic acid	143-160	carbamoyl-phosphate synthetase 1	Mus musculus	291-295
20097174-4	2010	We identified carbamoyl phosphate synthetase 1 (CPS1), a key enzyme of the urea cycle that catalyzes condensation of ammonia with bicarbonate to form carbamoyl phosphate, as a target of SIRT5 by two-dimensional electrophoresis comparing mitochondrial proteins in livers of SIRT5 Tg and wild-type mice.	Bicarbonates	130-141	carbamoyl-phosphate synthetase 1	Mus musculus	14-46
21540182-6	2011	Among various oxypurines tested, only IBMX, xanthine, or uric acid significantly increased the apparent K(m) for glutamate and decreased velocity of NAGS, with little effect on CPS1.	Xanthine	44-52	carbamoyl-phosphate synthetase 1	Mus musculus	177-181
21540182-6	2011	Among various oxypurines tested, only IBMX, xanthine, or uric acid significantly increased the apparent K(m) for glutamate and decreased velocity of NAGS, with little effect on CPS1.	Uric Acid	57-66	carbamoyl-phosphate synthetase 1	Mus musculus	177-181
20097174-4	2010	We identified carbamoyl phosphate synthetase 1 (CPS1), a key enzyme of the urea cycle that catalyzes condensation of ammonia with bicarbonate to form carbamoyl phosphate, as a target of SIRT5 by two-dimensional electrophoresis comparing mitochondrial proteins in livers of SIRT5 Tg and wild-type mice.	Urea	75-79	carbamoyl-phosphate synthetase 1	Mus musculus	14-46
20097174-4	2010	We identified carbamoyl phosphate synthetase 1 (CPS1), a key enzyme of the urea cycle that catalyzes condensation of ammonia with bicarbonate to form carbamoyl phosphate, as a target of SIRT5 by two-dimensional electrophoresis comparing mitochondrial proteins in livers of SIRT5 Tg and wild-type mice.	Bicarbonates	130-141	carbamoyl-phosphate synthetase 1	Mus musculus	48-52
20097174-4	2010	We identified carbamoyl phosphate synthetase 1 (CPS1), a key enzyme of the urea cycle that catalyzes condensation of ammonia with bicarbonate to form carbamoyl phosphate, as a target of SIRT5 by two-dimensional electrophoresis comparing mitochondrial proteins in livers of SIRT5 Tg and wild-type mice.	Urea	75-79	carbamoyl-phosphate synthetase 1	Mus musculus	48-52
20097174-4	2010	We identified carbamoyl phosphate synthetase 1 (CPS1), a key enzyme of the urea cycle that catalyzes condensation of ammonia with bicarbonate to form carbamoyl phosphate, as a target of SIRT5 by two-dimensional electrophoresis comparing mitochondrial proteins in livers of SIRT5 Tg and wild-type mice.	Ammonia	117-124	carbamoyl-phosphate synthetase 1	Mus musculus	14-46
20097174-4	2010	We identified carbamoyl phosphate synthetase 1 (CPS1), a key enzyme of the urea cycle that catalyzes condensation of ammonia with bicarbonate to form carbamoyl phosphate, as a target of SIRT5 by two-dimensional electrophoresis comparing mitochondrial proteins in livers of SIRT5 Tg and wild-type mice.	Carbamyl Phosphate	14-33	carbamoyl-phosphate synthetase 1	Mus musculus	48-52
20097174-4	2010	We identified carbamoyl phosphate synthetase 1 (CPS1), a key enzyme of the urea cycle that catalyzes condensation of ammonia with bicarbonate to form carbamoyl phosphate, as a target of SIRT5 by two-dimensional electrophoresis comparing mitochondrial proteins in livers of SIRT5 Tg and wild-type mice.	Ammonia	117-124	carbamoyl-phosphate synthetase 1	Mus musculus	48-52
20097174-8	2010	Because ammonia generated during fasting is toxic, SIRT5 protein might play a protective role by converting ammonia to non-toxic urea through deacetylation and activation of CPS1.	Ammonia	108-115	carbamoyl-phosphate synthetase 1	Mus musculus	174-178
20097174-8	2010	Because ammonia generated during fasting is toxic, SIRT5 protein might play a protective role by converting ammonia to non-toxic urea through deacetylation and activation of CPS1.	Urea	129-133	carbamoyl-phosphate synthetase 1	Mus musculus	174-178
19272383-12	2009	CONCLUSIONS: YB-1 is a key regulator of ammonia detoxification by negatively regulating CPS1 expression via suppression of C/EBPalpha function.	Ammonia	40-47	carbamoyl-phosphate synthetase 1	Mus musculus	88-92
19797073-8	2009	In addition, we show that uracil starvation of the cps1-1 strain induces early markers of bradyzoite differentiation.	Uracil	26-32	carbamoyl-phosphate synthetase 1	Mus musculus	51-55
19797073-9	2009	Collectively, these results suggest that more effective immune control of chronic type II infection in the genetically susceptible B6 background is established by vaccination with the nonreplicating type I uracil auxotroph cps1-1 strain.	Uracil	206-212	carbamoyl-phosphate synthetase 1	Mus musculus	223-227
19268669-4	2009	RESULTS: Under normal circumstances, the urea cycle enzyme carbamoylphosphate synthetase I (CPS I) is present in the periportal, intermediate, and the first few layers of the perivenous zone.	Urea	41-45	carbamoyl-phosphate synthetase 1	Mus musculus	59-90
19268669-4	2009	RESULTS: Under normal circumstances, the urea cycle enzyme carbamoylphosphate synthetase I (CPS I) is present in the periportal, intermediate, and the first few layers of the perivenous zone.	Urea	41-45	carbamoyl-phosphate synthetase 1	Mus musculus	92-97
19410549-3	2009	Here, we show that SIRT5 localizes in the mitochondrial matrix and interacts with carbamoyl phosphate synthetase 1 (CPS1), an enzyme, catalyzing the initial step of the urea cycle for ammonia detoxification and disposal.	Urea	169-173	carbamoyl-phosphate synthetase 1	Mus musculus	82-114
19410549-3	2009	Here, we show that SIRT5 localizes in the mitochondrial matrix and interacts with carbamoyl phosphate synthetase 1 (CPS1), an enzyme, catalyzing the initial step of the urea cycle for ammonia detoxification and disposal.	Urea	169-173	carbamoyl-phosphate synthetase 1	Mus musculus	116-120
19410549-3	2009	Here, we show that SIRT5 localizes in the mitochondrial matrix and interacts with carbamoyl phosphate synthetase 1 (CPS1), an enzyme, catalyzing the initial step of the urea cycle for ammonia detoxification and disposal.	Ammonia	184-191	carbamoyl-phosphate synthetase 1	Mus musculus	82-114
19410549-3	2009	Here, we show that SIRT5 localizes in the mitochondrial matrix and interacts with carbamoyl phosphate synthetase 1 (CPS1), an enzyme, catalyzing the initial step of the urea cycle for ammonia detoxification and disposal.	Ammonia	184-191	carbamoyl-phosphate synthetase 1	Mus musculus	116-120
19410549-5	2009	During fasting, NAD in liver mitochondria increases, thereby triggering SIRT5 deacetylation of CPS1 and adaptation to the increase in amino acid catabolism.	NAD	16-19	carbamoyl-phosphate synthetase 1	Mus musculus	95-99
19410549-8	2009	These findings demonstrate SIRT5 plays a pivotal role in ammonia detoxification and disposal by activating CPS1.	Ammonia	57-64	carbamoyl-phosphate synthetase 1	Mus musculus	107-111
17291196-5	2007	The protective effect of CPS against acute hepatic injuries induced by alcohol was verified in NH mice that were fed with different dosages of CPS for 30 days and subsequently given an acute dose of alcohol orally.	Alcohols	71-78	carbamoyl-phosphate synthetase 1	Mus musculus	25-28
17291196-5	2007	The protective effect of CPS against acute hepatic injuries induced by alcohol was verified in NH mice that were fed with different dosages of CPS for 30 days and subsequently given an acute dose of alcohol orally.	Alcohols	199-206	carbamoyl-phosphate synthetase 1	Mus musculus	25-28
17291196-6	2007	As a result, CPS reduced both hepatic malondialdehyde and triacylglycerol levels, along with enhanced hepatic GSH (glutathione) levels, relative to the control.	Malondialdehyde	38-53	carbamoyl-phosphate synthetase 1	Mus musculus	13-16
17291196-6	2007	As a result, CPS reduced both hepatic malondialdehyde and triacylglycerol levels, along with enhanced hepatic GSH (glutathione) levels, relative to the control.	Triglycerides	58-73	carbamoyl-phosphate synthetase 1	Mus musculus	13-16
17291196-6	2007	As a result, CPS reduced both hepatic malondialdehyde and triacylglycerol levels, along with enhanced hepatic GSH (glutathione) levels, relative to the control.	Glutathione	110-113	carbamoyl-phosphate synthetase 1	Mus musculus	13-16
17291196-6	2007	As a result, CPS reduced both hepatic malondialdehyde and triacylglycerol levels, along with enhanced hepatic GSH (glutathione) levels, relative to the control.	Glutathione	115-126	carbamoyl-phosphate synthetase 1	Mus musculus	13-16
17291196-8	2007	The result indicates that CPS is capable of attenuating ethanol-induced hepatic injury.	Ethanol	56-63	carbamoyl-phosphate synthetase 1	Mus musculus	26-29
16790766-4	2006	Deletion of the CPS1 gene from a serotype D strain of C. neoformans resulted in a slight reduction of the capsule size as observed by using an India ink preparation.	chinese ink	143-152	carbamoyl-phosphate synthetase 1	Mus musculus	16-20
16790766-7	2006	A hyaluronan enzyme-linked immunosorbent assay method demonstrated that CPS1 is important for the synthesis of hyaluronan or its related polysaccharides in C. neoformans.	Hyaluronic Acid	2-12	carbamoyl-phosphate synthetase 1	Mus musculus	72-76
16108375-1	2005	Klebsiella pneumoniae was cultured followed by the preparation and immunoactivity elucidating of its polysaccharide (CPS).	Polysaccharides	101-115	carbamoyl-phosphate synthetase 1	Mus musculus	117-120
16108375-3	2005	Crude CPS was got by ethanol precipitation, then purified through the Ion-exchange and gel filtration, the purity of CPS was judged by the gel filtration and agarose gel electrophoresis.	Ethanol	21-28	carbamoyl-phosphate synthetase 1	Mus musculus	6-9
16111053-5	2005	In diabetic mice, the fasted and ad lib blood glucose after administering CPS orally 2h, 4h were lower than that of control group (P < 0.05 and P < 0.01 respectively).	Glucose	46-53	carbamoyl-phosphate synthetase 1	Mus musculus	74-77
16111053-5	2005	In diabetic mice, the fasted and ad lib blood glucose after administering CPS orally 2h, 4h were lower than that of control group (P < 0.05 and P < 0.01 respectively).	Deuterium	85-87	carbamoyl-phosphate synthetase 1	Mus musculus	74-77
16111053-5	2005	In diabetic mice, the fasted and ad lib blood glucose after administering CPS orally 2h, 4h were lower than that of control group (P < 0.05 and P < 0.01 respectively).	4h	89-91	carbamoyl-phosphate synthetase 1	Mus musculus	74-77
15261384-0	2004	Isolation and biological properties of polysaccharide CPS-1 from cultured Cordyceps militaris.	Polysaccharides	39-53	carbamoyl-phosphate synthetase 1	Mus musculus	54-59
15261384-3	2004	The structure of polysaccharide CPS-1 was elucidated by sugar analysis, Smith degradation, IR and 13C-NMR spectroscopy.	Polysaccharides	17-31	carbamoyl-phosphate synthetase 1	Mus musculus	32-37
15261384-3	2004	The structure of polysaccharide CPS-1 was elucidated by sugar analysis, Smith degradation, IR and 13C-NMR spectroscopy.	Sugars	56-61	carbamoyl-phosphate synthetase 1	Mus musculus	32-37
15261384-3	2004	The structure of polysaccharide CPS-1 was elucidated by sugar analysis, Smith degradation, IR and 13C-NMR spectroscopy.	13c	98-101	carbamoyl-phosphate synthetase 1	Mus musculus	32-37