PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
25194819-7	2014	Galphas/cAMP/PKA activation inhibits ETAR-mediated beta-arrestin activation of angiogenic/metastatic Calcrl and Icam2 expression.	galphas	0-7	intercellular adhesion molecule 2	Homo sapiens	112-117
25636890-7	2015	In addition, PA down-regulated CD63, GRB-2, ICAM-2 and STAB-1 that are implicated in adhesion, migration and tube formation of endothelial cells.	panduratin A	13-15	intercellular adhesion molecule 2	Homo sapiens	44-50
25194819-7	2014	Galphas/cAMP/PKA activation inhibits ETAR-mediated beta-arrestin activation of angiogenic/metastatic Calcrl and Icam2 expression.	Cyclic AMP	8-12	intercellular adhesion molecule 2	Homo sapiens	112-117
23714211-0	2013	N-glycosylation of ICAM-2 is required for ICAM-2-mediated complete suppression of metastatic potential of SK-N-AS neuroblastoma cells.	Nitrogen	0-1	intercellular adhesion molecule 2	Homo sapiens	19-25
23714211-0	2013	N-glycosylation of ICAM-2 is required for ICAM-2-mediated complete suppression of metastatic potential of SK-N-AS neuroblastoma cells.	Nitrogen	0-1	intercellular adhesion molecule 2	Homo sapiens	42-48
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Leucine	199-202	intercellular adhesion molecule 2	Homo sapiens	444-450
22647882-4	2012	Upon human umbilical vein endothelial cells Castanospermine reduced the mean fluorescence intensity ratios of E-selectin (p=0.003), ICAM-1 (p<0.001), ICAM-2 (p=0.004) and PECAM-1 (p<0.001) but increased it for P-selectin (p<0.001).	castanospermine	44-59	intercellular adhesion molecule 2	Homo sapiens	153-159
22096380-7	2010	Expression of three common adhesion molecules, intercellular adhesion molecule-1 (ICAM1), ICAM2, and vascular cell adhesion molecule, was unchanged or slightly decreased by ethanol.	Ethanol	173-180	intercellular adhesion molecule 2	Homo sapiens	90-95
18951915-8	2009	A BHK cell line stably expressing pDC-SIGN binds to human ICAM-3 and ICAM-2 immunoadhesins in a calcium-dependent manner, and enhances the transmission of porcine reproductive and respiratory syndrome virus (PRRSV) to target cells in trans.	Calcium	96-103	intercellular adhesion molecule 2	Homo sapiens	69-75
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Hydrogen	271-279	intercellular adhesion molecule 2	Homo sapiens	444-450
18753140-5	2008	Like Motif-1 binding, the CD44 beta strand binds the shallow groove between strand beta5C and helix alpha1C and augments the beta sheet beta5C-beta7C from subdomain C. Two hydrophobic CD44 residues, Leu and Ile, are docked into a hydrophobic pocket with the formation of hydrogen bonds between Asn of the CD44 short loop and loop beta4C-beta5C from subdomain C. This binding mode resembles that of NEP (neutral endopeptidase 24.11) rather than ICAM-2.	Asparagine	294-297	intercellular adhesion molecule 2	Homo sapiens	444-450
18155766-6	2008	The interaction between DC-SIGN on dendritic cells and ICAM-2 on endothelial cells is strictly glycan-specific.	Polysaccharides	95-101	intercellular adhesion molecule 2	Homo sapiens	55-61
16857989-5	2006	We show that mutation of the serine phosphorylation site leads to inability of Mac-1 to become activated to bind the cellular ligands ICAM-1 and ICAM-2.	Serine	29-35	intercellular adhesion molecule 2	Homo sapiens	145-151
18209096-7	2008	Selective involvement of the LFA-1-ICAM-2 pathway was confirmed by the finding of increased ezrin phosphorylation at Tyr(353) that is known to be downstream of ICAM-2 and supports cell survival through Akt activation.	Tyrosine	117-120	intercellular adhesion molecule 2	Homo sapiens	35-41
18209096-7	2008	Selective involvement of the LFA-1-ICAM-2 pathway was confirmed by the finding of increased ezrin phosphorylation at Tyr(353) that is known to be downstream of ICAM-2 and supports cell survival through Akt activation.	Tyrosine	117-120	intercellular adhesion molecule 2	Homo sapiens	160-166
18076570-5	2007	The Motif-1 3(10) helix present in the FERM-ICAM-2 complex is absent in PSGL-1 given the absence of a critical Motif-1 alanine residue, and PSGL-1 reduces its contact area with subdomain C. Non-conserved positions are occupied by large residues Met9 and His8, which stabilize peptide conformation and enhance groove binding.	Alanine	119-126	intercellular adhesion molecule 2	Homo sapiens	44-50
17096550-4	2006	LFA-1 binding to ICAM-1 and ICAM-2 was strengthened in the slow loading regime by the addition of Mg(2+).	Magnesium	98-100	intercellular adhesion molecule 2	Homo sapiens	28-34
15545280-3	2005	The first N-linked glycan in ICAM-2 contacts an exposed tryptophan residue, defining a conserved glycan-W motif critical for the conformation of the integrin binding domain.	n-linked glycan	10-25	intercellular adhesion molecule 2	Homo sapiens	29-35
15920013-8	2005	ICAM-2-deficient cells show defective in vitro migration, as well as increased apoptosis in response to serum deprivation, anti-Fas antibody, or staurosporine.	Staurosporine	145-158	intercellular adhesion molecule 2	Homo sapiens	0-6
15545280-3	2005	The first N-linked glycan in ICAM-2 contacts an exposed tryptophan residue, defining a conserved glycan-W motif critical for the conformation of the integrin binding domain.	Tryptophan	56-66	intercellular adhesion molecule 2	Homo sapiens	29-35
15545280-3	2005	The first N-linked glycan in ICAM-2 contacts an exposed tryptophan residue, defining a conserved glycan-W motif critical for the conformation of the integrin binding domain.	Polysaccharides	19-25	intercellular adhesion molecule 2	Homo sapiens	29-35
15545280-3	2005	The first N-linked glycan in ICAM-2 contacts an exposed tryptophan residue, defining a conserved glycan-W motif critical for the conformation of the integrin binding domain.	Tungsten	104-105	intercellular adhesion molecule 2	Homo sapiens	29-35
15545280-5	2005	Experiments with soluble molecules having the N-terminal two domains of human ICAMs identified glycans of the high mannose type N-linked to the second domain of the dendritic cell-specific ICAM-grabbing nonintegrin lectin-ligands ICAM-2 and ICAM-3.	Polysaccharides	95-102	intercellular adhesion molecule 2	Homo sapiens	230-236
15545280-5	2005	Experiments with soluble molecules having the N-terminal two domains of human ICAMs identified glycans of the high mannose type N-linked to the second domain of the dendritic cell-specific ICAM-grabbing nonintegrin lectin-ligands ICAM-2 and ICAM-3.	Mannose	115-122	intercellular adhesion molecule 2	Homo sapiens	230-236
15377434-5	2004	RESULTS: DC-SIGN, a dendritic cell-specific adhesion receptor and a type II transmembrane mannose-binding C-type lectin, is very important in the function of dendritic cells (DC), both in mediating naive T cell interactions through ICAM-3 and as a rolling receptor that mediates the DC-specific ICAM-2-dependent migration processes.	Mannose	90-97	intercellular adhesion molecule 2	Homo sapiens	295-301
12234361-6	2002	C-type lectins such as DC-SIGN contain a lectin domain that recognizes in a Ca2+-dependent manner carbohydrates such as mannose-containing structures presented on the glycoproteins ICAM-2 and ICAM-3.	Carbohydrates	98-111	intercellular adhesion molecule 2	Homo sapiens	181-187
14970226-10	2004	Conversely, mutating the moderately conserved residue (Gly-346) abrogated gp120 binding but enhanced ICAM-2 and ICAM-3 binding.	Glycine	55-58	intercellular adhesion molecule 2	Homo sapiens	101-107
12527821-15	2002	On TNFalpha-activated HUVECs, NAAGA induced a significant decrease in the VCAM-1 expression level (P<0.0001) and totally reversed TNFalpha-induced overexpression of ICAM-1 (P=0.0069), ICAM-2 and ELAM-1 (P<0.0001), without interfering with baseline expression of these molecules.	isospaglumic acid	30-35	intercellular adhesion molecule 2	Homo sapiens	187-193
12234361-6	2002	C-type lectins such as DC-SIGN contain a lectin domain that recognizes in a Ca2+-dependent manner carbohydrates such as mannose-containing structures presented on the glycoproteins ICAM-2 and ICAM-3.	Mannose	120-127	intercellular adhesion molecule 2	Homo sapiens	181-187
10688433-9	1999	Calcium ionophore (1 microM) significantly increased Mac-1 and ICAM-1 expression at 6 and 24 h. L-selectin expression decreased at 6 and 24 h, but ICAM-2, ICAM-3, LFA-1, and CD29 expression did not show any significant change after calcium ionophore stimulation.	Calcium	0-7	intercellular adhesion molecule 2	Homo sapiens	147-153
11825565-2	2002	ICAM-2 induced tyrosine phosphorylation of ezrin and PI3K kinase membrane translocation, resulting in phosphatidylinositol 3,4,5 production, PDK-1 and AKT activation, and subsequent phosphorylation of AKT targets BAD, GSK3, and FKHR.	Tyrosine	15-23	intercellular adhesion molecule 2	Homo sapiens	0-6
11825565-2	2002	ICAM-2 induced tyrosine phosphorylation of ezrin and PI3K kinase membrane translocation, resulting in phosphatidylinositol 3,4,5 production, PDK-1 and AKT activation, and subsequent phosphorylation of AKT targets BAD, GSK3, and FKHR.	Phosphatidylinositols	102-122	intercellular adhesion molecule 2	Homo sapiens	0-6
9705328-7	1998	PtdIns(4, 5)P2 was shown to bind to cytoplasmic tails of ICAM-1 and ICAM-2, which are the first adhesion proteins demonstrated to interact with PtdIns(4,5)P2.	Phosphatidylinositol 4,5-Diphosphate	0-14	intercellular adhesion molecule 2	Homo sapiens	68-74
9705328-7	1998	PtdIns(4, 5)P2 was shown to bind to cytoplasmic tails of ICAM-1 and ICAM-2, which are the first adhesion proteins demonstrated to interact with PtdIns(4,5)P2.	Phosphatidylinositol 4,5-Diphosphate	144-157	intercellular adhesion molecule 2	Homo sapiens	68-74
9705328-6	1998	The calculated KD value was 3.3 x 10(-7) M. Phosphatidylinositol 4, 5-bisphosphate (PtdIns(4,5)P2) induced an interaction of ezrin and ICAM-1 and enhanced the interaction of ezrin and ICAM-2, but ICAM-3 did not bind ezrin even in the presence of PtdIns(4,5)P2.	Phosphatidylinositol 4,5-Diphosphate	44-82	intercellular adhesion molecule 2	Homo sapiens	184-190
9705328-6	1998	The calculated KD value was 3.3 x 10(-7) M. Phosphatidylinositol 4, 5-bisphosphate (PtdIns(4,5)P2) induced an interaction of ezrin and ICAM-1 and enhanced the interaction of ezrin and ICAM-2, but ICAM-3 did not bind ezrin even in the presence of PtdIns(4,5)P2.	Phosphatidylinositol 4,5-Diphosphate	84-97	intercellular adhesion molecule 2	Homo sapiens	184-190
9326242-0	1997	Retinoic acid induces aggregation of the acute promyelocytic leukemia cell line NB-4 by utilization of LFA-1 and ICAM-2.	Tretinoin	0-13	intercellular adhesion molecule 2	Homo sapiens	113-119
8590771-6	1995	Immunoprecipitation experiments using platelet lysates and anti-ICAM-2 monoclonal antibody demonstrated that ICAM-2 molecules had a molecular weight similar to p62 on SDS-PAGE.	Sodium Dodecyl Sulfate	167-170	intercellular adhesion molecule 2	Homo sapiens	109-115
7721764-9	1995	Phosphotyrosine immunoblotting experiments showed that the ICAM-2 peptide increased the phosphorylation of 150- and 35-kDa proteins.	Phosphotyrosine	0-15	intercellular adhesion molecule 2	Homo sapiens	59-65
8083366-3	1994	ICAM-2 isolated from platelets migrates as a band of 59,000 M(r) in reducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	Sodium Dodecyl Sulfate	77-99	intercellular adhesion molecule 2	Homo sapiens	0-6
8083366-3	1994	ICAM-2 isolated from platelets migrates as a band of 59,000 M(r) in reducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	polyacrylamide	100-114	intercellular adhesion molecule 2	Homo sapiens	0-6
8083366-8	1994	Activation of T lymphocytes with PMA stimulated binding to platelets that was Mg2+ dependent and could be specifically inhibited by mAbs to either ICAM-2 or leukocyte function-associated antigen-1.	Tetradecanoylphorbol Acetate	33-36	intercellular adhesion molecule 2	Homo sapiens	147-153
8083366-8	1994	Activation of T lymphocytes with PMA stimulated binding to platelets that was Mg2+ dependent and could be specifically inhibited by mAbs to either ICAM-2 or leukocyte function-associated antigen-1.	magnesium ion	78-82	intercellular adhesion molecule 2	Homo sapiens	147-153
7916295-3	1994	We observed that phorbol 12-myristate 13-acetate, Mn2+, cross-linking of CD3 or activating antibodies against LFA-1 enhanced LFA-1-mediated T cell adhesion to ICAM-2 and -3, although to a lesser extent than to ICAM-1.	Tetradecanoylphorbol Acetate	17-48	intercellular adhesion molecule 2	Homo sapiens	159-172
7916295-3	1994	We observed that phorbol 12-myristate 13-acetate, Mn2+, cross-linking of CD3 or activating antibodies against LFA-1 enhanced LFA-1-mediated T cell adhesion to ICAM-2 and -3, although to a lesser extent than to ICAM-1.	Manganese(2+)	50-54	intercellular adhesion molecule 2	Homo sapiens	159-172
1676048-2	1991	Immunoprecipitated, reduced ICAM-2 migrated as a broad band of Mr 60,000 in sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	Sodium Dodecyl Sulfate	76-98	intercellular adhesion molecule 2	Homo sapiens	28-34
1676048-2	1991	Immunoprecipitated, reduced ICAM-2 migrated as a broad band of Mr 60,000 in sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	polyacrylamide	99-113	intercellular adhesion molecule 2	Homo sapiens	28-34
1676048-9	1991	One of the two mAb, CBR-IC2/2, was found to totally inhibit binding of ICAM-2+ COS cells to purified lymphocyte function-associated antigen-1 (LFA-1).	carbonyl sulfide	79-82	intercellular adhesion molecule 2	Homo sapiens	71-77