PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
20078778-3	2010	In this article, we provide genetic evidence that the primary genes involved in lignin biosynthesis in Arabidopsis, CAD-C and CAD-D, act as essential components of defence to virulent and avirulent strains of the bacterial pathogen Pseudomonas syringae pv.	Lignin	80-86	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	116-121
17467016-26	2007	By contrast, AtCAD7 and AtCAD8 [surprisingly now currently TAIR-annotated as probable mannitol dehydrogenases, but for which there is still no biochemical or other evidence for same] displayed gene expression patterns largely resembling those of AtCAD4/5, i.e. indicative perhaps of a quite minor role in monolignol/lignin formation.	monolignol	305-315	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	246-254
17467016-26	2007	By contrast, AtCAD7 and AtCAD8 [surprisingly now currently TAIR-annotated as probable mannitol dehydrogenases, but for which there is still no biochemical or other evidence for same] displayed gene expression patterns largely resembling those of AtCAD4/5, i.e. indicative perhaps of a quite minor role in monolignol/lignin formation.	Lignin	316-322	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	246-254
17467016-27	2007	Lastly, AtCAD1 (At1g72680), AtCAD6 (At4g37970) and AtCAD9 (At4g39330), which lacked detectable CAD catalytic activities in vitro, were also expressed predominantly in vascular (lignin-forming) tissues.	Lignin	177-183	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	10-13
15937231-1	2005	During lignin biosynthesis in angiosperms, coniferyl and sinapyl aldehydes are believed to be converted into their corresponding alcohols by cinnamyl alcohol dehydrogenase (CAD) and by sinapyl alcohol dehydrogenase (SAD), respectively.	Lignin	7-13	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	173-176
17559892-1	2007	The lignin deficient double mutant of cinnamyl alcohol dehydrogenase (CAD, cad-4, cad-5 or cad-c, cad-d) in Arabidopsis thaliana [Sibout, R., Eudes, A., Mouille, G., Pollet, B., Lapierre, C., Jouanin, L., Seguin, A., 2005.	Lignin	4-10	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	75-80
17559892-1	2007	The lignin deficient double mutant of cinnamyl alcohol dehydrogenase (CAD, cad-4, cad-5 or cad-c, cad-d) in Arabidopsis thaliana [Sibout, R., Eudes, A., Mouille, G., Pollet, B., Lapierre, C., Jouanin, L., Seguin, A., 2005.	Lignin	4-10	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	75-78
17559892-1	2007	The lignin deficient double mutant of cinnamyl alcohol dehydrogenase (CAD, cad-4, cad-5 or cad-c, cad-d) in Arabidopsis thaliana [Sibout, R., Eudes, A., Mouille, G., Pollet, B., Lapierre, C., Jouanin, L., Seguin, A., 2005.	Lignin	4-10	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	82-85
16633561-2	2006	In Arabidopsis thaliana, the two isoforms, AtCAD5 and AtCAD4, are the catalytically most active being viewed as mainly involved in the formation of guaiacyl/syringyl lignins.	guaiacyl	148-156	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	54-60
16633561-2	2006	In Arabidopsis thaliana, the two isoforms, AtCAD5 and AtCAD4, are the catalytically most active being viewed as mainly involved in the formation of guaiacyl/syringyl lignins.	Lignin	166-173	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	54-60
16633561-4	2006	Both AtCAD5 and AtCAD4 are dimers with two zinc ions per subunit and belong to the Zn-dependent medium chain dehydrogenase/reductase (MDR) superfamily, on the basis of their overall 2-domain structures and distribution of secondary structural elements.	Zinc	83-85	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	16-22
15937231-1	2005	During lignin biosynthesis in angiosperms, coniferyl and sinapyl aldehydes are believed to be converted into their corresponding alcohols by cinnamyl alcohol dehydrogenase (CAD) and by sinapyl alcohol dehydrogenase (SAD), respectively.	coniferyl and sinapyl aldehydes	43-74	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	173-176
15937231-1	2005	During lignin biosynthesis in angiosperms, coniferyl and sinapyl aldehydes are believed to be converted into their corresponding alcohols by cinnamyl alcohol dehydrogenase (CAD) and by sinapyl alcohol dehydrogenase (SAD), respectively.	Alcohols	129-137	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	173-176
15937231-2	2005	This work clearly shows that CAD-C and CAD-D act as the primary genes involved in lignin biosynthesis in the floral stem of Arabidopsis thaliana by supplying both coniferyl and sinapyl alcohols.	Lignin	82-88	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	29-32
15937231-2	2005	This work clearly shows that CAD-C and CAD-D act as the primary genes involved in lignin biosynthesis in the floral stem of Arabidopsis thaliana by supplying both coniferyl and sinapyl alcohols.	Lignin	82-88	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	39-42
15937231-2	2005	This work clearly shows that CAD-C and CAD-D act as the primary genes involved in lignin biosynthesis in the floral stem of Arabidopsis thaliana by supplying both coniferyl and sinapyl alcohols.	coniferyl and sinapyl alcohols	163-193	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	29-32
15937231-2	2005	This work clearly shows that CAD-C and CAD-D act as the primary genes involved in lignin biosynthesis in the floral stem of Arabidopsis thaliana by supplying both coniferyl and sinapyl alcohols.	coniferyl and sinapyl alcohols	163-193	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	39-42
15937231-3	2005	An Arabidopsis CAD double mutant (cad-c cad-d) resulted in a phenotype with a limp floral stem at maturity as well as modifications in the pattern of lignin staining.	Lignin	150-156	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	15-18
15937231-3	2005	An Arabidopsis CAD double mutant (cad-c cad-d) resulted in a phenotype with a limp floral stem at maturity as well as modifications in the pattern of lignin staining.	Lignin	150-156	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	34-37
15937231-3	2005	An Arabidopsis CAD double mutant (cad-c cad-d) resulted in a phenotype with a limp floral stem at maturity as well as modifications in the pattern of lignin staining.	Lignin	150-156	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	40-43
15937231-7	2005	In addition, molecular complementation of the double mutant by tissue-specific expression of CAD derived from various species suggests different abilities of these genes/proteins to produce syringyl-lignin moieties but does not indicate a requirement for any specific SAD gene.	Lignin	199-205	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	93-96
25822199-8	2015	Functional annotation noted down-regulation of UDP-glycosyl transferase, 4-coumarate CoA ligase 8, cinnamyl alcohol dehydrogenase 4 (CAD4), ACC synthase and ACC oxidase which are the important enzymes of phenylpropanoid, lignin and ethylene (ET) biosynthetic pathway respectively.	phenylpropanoid	204-219	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	99-131
14745009-4	2004	AtCAD5 used all five substrates effectively, whereas AtCAD4 (of lower overall catalytic capacity) poorly used sinapyl aldehyde; the corresponding 270-fold decrease in k(enz) resulted from higher K(m) and lower k(cat) values, respectively.	sinapyl aldehyde	110-126	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	53-59
12805615-5	2003	Among nine AtCAD genes, we have identified the two distinct paralogs AtCAD-C and AtCAD-D, which share 75% identity and are likely to be involved in lignin biosynthesis in other plants.	Lignin	148-154	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	69-76
35522042-7	2022	The med5a/5b ref8-1 cadc cadd plants are viable, but lignin analysis demonstrated that they continue to synthesize p-hydroxyphenyl lignin despite being mutated for the CADs typically considered to be required for monolignol biosynthesis.	p-hydroxyphenyl lignin	115-137	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	20-24
25822199-8	2015	Functional annotation noted down-regulation of UDP-glycosyl transferase, 4-coumarate CoA ligase 8, cinnamyl alcohol dehydrogenase 4 (CAD4), ACC synthase and ACC oxidase which are the important enzymes of phenylpropanoid, lignin and ethylene (ET) biosynthetic pathway respectively.	Lignin	221-227	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	99-131
25822199-8	2015	Functional annotation noted down-regulation of UDP-glycosyl transferase, 4-coumarate CoA ligase 8, cinnamyl alcohol dehydrogenase 4 (CAD4), ACC synthase and ACC oxidase which are the important enzymes of phenylpropanoid, lignin and ethylene (ET) biosynthetic pathway respectively.	ethylene	232-240	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	99-131
25822199-8	2015	Functional annotation noted down-regulation of UDP-glycosyl transferase, 4-coumarate CoA ligase 8, cinnamyl alcohol dehydrogenase 4 (CAD4), ACC synthase and ACC oxidase which are the important enzymes of phenylpropanoid, lignin and ethylene (ET) biosynthetic pathway respectively.	ethylene	242-244	GroES-like zinc-binding alcohol dehydrogenase family protein	Arabidopsis thaliana	99-131