PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34297995-0	2021	Melatonin promotes in vitro maturation of vitrified-warmed mouse GV oocytes potentially by modulating MAD2 protein expression of SAC component through MTRs.	Melatonin	0-9	MAD2 mitotic arrest deficient-like 1	Mus musculus	102-106
10706629-5	2000	The ERbeta-MAD2 interaction was identified by screening of a yeast two-hybrid system vascular endothelial cell library with ERbeta and confirmed with glutathione S-transferase-fusion protein interaction studies.	Glutathione	150-161	MAD2 mitotic arrest deficient-like 1	Mus musculus	11-15
34297995-8	2021	However, when MT or ramelteon (MTRs agonist) were added (group wise) to warming and maturation media, the maturation rate of GV oocytes was significantly increased, the normal proportion of the spindle morphology increased, and the expression level of MAD2 increased in their resulting MI oocytes compared to the vitrification group.	ramelteon	20-29	MAD2 mitotic arrest deficient-like 1	Mus musculus	252-256
3182109-3	1988	MAD2 cross-reacts to varying degrees with anthracycline compounds such as some DXR analogues and derivatives, but does not recognize anthracene and anthraquinone structures, with the exception of weakly reacting Mitoxantrone.	Anthracyclines	42-55	MAD2 mitotic arrest deficient-like 1	Mus musculus	0-4
3182109-3	1988	MAD2 cross-reacts to varying degrees with anthracycline compounds such as some DXR analogues and derivatives, but does not recognize anthracene and anthraquinone structures, with the exception of weakly reacting Mitoxantrone.	Mitoxantrone	212-224	MAD2 mitotic arrest deficient-like 1	Mus musculus	0-4
3182109-4	1988	MAD2 and the panel of MAbs which are at present being purified may become a tool for studying the relevance of different domains of the anthracyclin molecule in terms of biologic activity.	anthracyclin	136-148	MAD2 mitotic arrest deficient-like 1	Mus musculus	0-4
33634101-9	2020	Additionally, the appearance of gammaH2AX and the significantly increased expression of Aurora B and MAD2L1 suggested that administration of relatively high doses of eCG caused Aurora B-mediated SAC activation triggered by ROS-induced DNA damage in early mouse IVF-derived embryos for self-correction of aneuploidy formation.	Reactive Oxygen Species	223-226	MAD2 mitotic arrest deficient-like 1	Mus musculus	101-107
31264311-2	2019	Our previous experiments suggested that reactive oxygen species (ROS) can activate Mad2, a key protein in the spindle assembly checkpoint (SAC), and delay the first mitotic, providing time to prevent the formation of embryonic aneuploidy.	Reactive Oxygen Species	40-63	MAD2 mitotic arrest deficient-like 1	Mus musculus	83-87
31817479-7	2019	Furthermore, deletion of MAD2 increases growth on fluconazole, and fluconazole treatment elevates whole chromosome loss rates in the mad2 /  strain, suggesting that CaMad2 may be important for preventing fluconazole resistance via aneuploidy.	Fluconazole	50-61	MAD2 mitotic arrest deficient-like 1	Mus musculus	25-29
31817479-7	2019	Furthermore, deletion of MAD2 increases growth on fluconazole, and fluconazole treatment elevates whole chromosome loss rates in the mad2 /  strain, suggesting that CaMad2 may be important for preventing fluconazole resistance via aneuploidy.	Fluconazole	67-78	MAD2 mitotic arrest deficient-like 1	Mus musculus	133-137
31817479-7	2019	Furthermore, deletion of MAD2 increases growth on fluconazole, and fluconazole treatment elevates whole chromosome loss rates in the mad2 /  strain, suggesting that CaMad2 may be important for preventing fluconazole resistance via aneuploidy.	Fluconazole	67-78	MAD2 mitotic arrest deficient-like 1	Mus musculus	133-137
32668252-4	2020	Through longitudinal monitoring and multi-omics analysis in mice, we found distinct effects of protein, sugar, and fat dietary components, with dietary sugars increasing Mad2l1 expression and tumor proliferation.	Sugars	152-158	MAD2 mitotic arrest deficient-like 1	Mus musculus	170-176
32620073-9	2020	MTX increased the rate of abnormal chromosome alignment and affected the regulation of chromosome separation via disrupting the spindle morphology and reducing the mRNA expressions of MAD2 and Sgo1.	Methotrexate	0-3	MAD2 mitotic arrest deficient-like 1	Mus musculus	184-188
31606408-8	2019	C12 treatment reduced the interpolar distance between the two spindle poles, increased the chromosome congression index, inhibited chromosome movement, and increased the level of mitotic checkpoint complex proteins BubR1 and Mad2.	(Z)-14-methylpentadec-2-enoic acid	0-3	MAD2 mitotic arrest deficient-like 1	Mus musculus	225-229
31264311-2	2019	Our previous experiments suggested that reactive oxygen species (ROS) can activate Mad2, a key protein in the spindle assembly checkpoint (SAC), and delay the first mitotic, providing time to prevent the formation of embryonic aneuploidy.	Reactive Oxygen Species	65-68	MAD2 mitotic arrest deficient-like 1	Mus musculus	83-87
17229934-7	2007	2-ME sustained MAD2L1 expression at the centromeres and increased the number of meiosis I-blocked oocytes in a dose-dependent manner.	2-Methoxyestradiol	0-4	MAD2 mitotic arrest deficient-like 1	Mus musculus	15-21
21464947-8	2011	Mitotic check point control by mitotic arrest deficient-like 1 (MAD2L1) also was perturbed in Lmna(Dhe/+) cells.	Dihydroergotamine	99-102	MAD2 mitotic arrest deficient-like 1	Mus musculus	64-70
19904549-4	2010	However, we have subsequently discovered that all PICH-directed siRNA oligonucleotides that abolish the SAC also reduce Mad2 mRNA and protein expression.	Oligonucleotides	70-86	MAD2 mitotic arrest deficient-like 1	Mus musculus	120-124
21216274-5	2011	RESULTS: Mad2(+/-) HPCs were protected from cytotoxic effects in vivo of a cell-cycle-specific agent, Ara-C, events consistent with Mad2(+/-) HPCs being in a slow or noncycling state, but not from recovery of functional HPC after treatment with non-cycle-specific cyclophosphamide or sublethal irradiation.	Cytarabine	102-107	MAD2 mitotic arrest deficient-like 1	Mus musculus	9-13
21216274-5	2011	RESULTS: Mad2(+/-) HPCs were protected from cytotoxic effects in vivo of a cell-cycle-specific agent, Ara-C, events consistent with Mad2(+/-) HPCs being in a slow or noncycling state, but not from recovery of functional HPC after treatment with non-cycle-specific cyclophosphamide or sublethal irradiation.	Cytarabine	102-107	MAD2 mitotic arrest deficient-like 1	Mus musculus	132-136
21216274-5	2011	RESULTS: Mad2(+/-) HPCs were protected from cytotoxic effects in vivo of a cell-cycle-specific agent, Ara-C, events consistent with Mad2(+/-) HPCs being in a slow or noncycling state, but not from recovery of functional HPC after treatment with non-cycle-specific cyclophosphamide or sublethal irradiation.	Cyclophosphamide	264-280	MAD2 mitotic arrest deficient-like 1	Mus musculus	9-13
15563594-6	2004	By using UBR60 cells, which carry tetracycline-regulated expression of BRCA1, we demonstrated that BRCA1 binds to transcription factor OCT-1 and up-regulates the transcription of MAD2.	Tetracycline	34-46	MAD2 mitotic arrest deficient-like 1	Mus musculus	179-183
16322543-7	2005	These effects are SAC-mediated as, in oocytes depleted of the majority of Mad2 by morpholino antisense, securin and cyclin B are destabilised and 15% of oocytes undergo PBE.	Morpholinos	82-92	MAD2 mitotic arrest deficient-like 1	Mus musculus	74-78
15361829-8	2004	Our results suggest that budesonide exerts its effects of chemoprevention through growth arrest via Mad2/3 and through apoptosis via Bim/Blk and, by inference, caspase-8/9.	Budesonide	25-35	MAD2 mitotic arrest deficient-like 1	Mus musculus	100-106
11479202-3	2001	Suppression of Mad2 was also observed in aryl hydrocarbon receptor-deficient mouse embryonic fibroblasts, suggesting that TCDD suppresses Mad2 by a novel TCDD receptor signaling mechanism.	Polychlorinated Dibenzodioxins	122-126	MAD2 mitotic arrest deficient-like 1	Mus musculus	15-19
11479202-3	2001	Suppression of Mad2 was also observed in aryl hydrocarbon receptor-deficient mouse embryonic fibroblasts, suggesting that TCDD suppresses Mad2 by a novel TCDD receptor signaling mechanism.	Polychlorinated Dibenzodioxins	122-126	MAD2 mitotic arrest deficient-like 1	Mus musculus	138-142