PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
15147897-3	2004	Our findings have demonstrated that the region from transmembrane segment (TM) 4 to the C-terminus of the GABA(A) receptor alpha1 subunit is crucial for the action of 5alpha-THDOC, but insufficient for the action of another neurosteroid allopregnanolone, suggesting that a specific region critical for neurosteroid action at GABA receptors exists in the domain between TM4 and the C-terminus of GABA receptor subunits.	tetrahydrodeoxycorticosterone	167-179	tropomyosin 4 S homeolog	Xenopus laevis	369-372
16622040-2	2006	Recently, it was shown that ethanol inhibition of NMDA receptors was reduced by mutation of residues in the transmembrane (TM) segment 3 of the NR1 subunit (F639A) or in TM4 of the NR2A subunit (A825W), suggesting putative ethanol binding sites.	Ethanol	28-35	tropomyosin 4 S homeolog	Xenopus laevis	170-173
10636871-4	2000	Biochemical ATPase assays demonstrated a large sodium-independent ATPase activity at pH 6.0 for the pump carrying the TM4 substitutions, whereas the control constructs exhibited little or no activity in the absence of sodium.	Sodium	47-53	tropomyosin 4 S homeolog	Xenopus laevis	118-121
10636871-8	2000	ATPase assays also revealed a 10-fold shift in vanadate sensitivity for the TM4 construct.	Vanadates	47-55	tropomyosin 4 S homeolog	Xenopus laevis	76-79
25969535-3	2015	Tryptophan substitution was poorly tolerated in all domains, with the greatest impact in TM1 and TM4.	Tryptophan	0-10	tropomyosin 4 S homeolog	Xenopus laevis	97-100
21326622-3	2010	In the present study, we investigated the proximity of A288 in TM3 to residues in TM4 from M404 to K411.	a288	55-59	tropomyosin 4 S homeolog	Xenopus laevis	82-85
21326622-8	2010	In addition, when HgCl(2) was coapplied with glycine, responses were changed in the A288C/Y406C, A288C/I409C, and A288C/Y410C double mutants, suggesting that agonist-induced rotation of TM4 allows A288C/Y406C and A288C/I409C to cross-link.	Glycine	45-52	tropomyosin 4 S homeolog	Xenopus laevis	186-189