PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
17827975-0	2007	The antifungal activity of RsAFP2, a plant defensin from raphanus sativus, involves the induction of reactive oxygen species in Candida albicans.	Reactive Oxygen Species	101-124	defensin-like protein 2	Raphanus sativus	27-33
17827975-4	2007	We show that RsAFP2 induces reactive oxygen species (ROS) in Candida albicans wild type in a dose-dependent manner, but not at all in an RsAFP2-resistant DeltagcsC.	Reactive Oxygen Species	28-51	defensin-like protein 2	Raphanus sativus	13-19
17827975-4	2007	We show that RsAFP2 induces reactive oxygen species (ROS) in Candida albicans wild type in a dose-dependent manner, but not at all in an RsAFP2-resistant DeltagcsC.	Reactive Oxygen Species	53-56	defensin-like protein 2	Raphanus sativus	13-19
17827975-1	2007	RsAFP2 (Raphanus sativus antifungal peptide 2), an antifungal plant defensin isolated from seed of R. sativus, interacts with glucosylceramides (GlcCer) in membranes of susceptible yeast and fungi and induces membrane permeabilization and fungal cell death.	Glucosylceramides	126-143	defensin-like protein 2	Raphanus sativus	0-6
17827975-6	2007	These findings indicate that upstream binding of RsAFP2 to GlcCer is needed for ROS production leading to yeast cell death.	Reactive Oxygen Species	80-83	defensin-like protein 2	Raphanus sativus	49-55
17827975-1	2007	RsAFP2 (Raphanus sativus antifungal peptide 2), an antifungal plant defensin isolated from seed of R. sativus, interacts with glucosylceramides (GlcCer) in membranes of susceptible yeast and fungi and induces membrane permeabilization and fungal cell death.	Glucosylceramides	126-143	defensin-like protein 2	Raphanus sativus	8-45
26592804-0	2016	The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilms.	Caspofungin	64-75	defensin-like protein 2	Raphanus sativus	32-38
17827975-7	2007	Moreover, the antioxidant ascorbic acid blocks RsAFP2-induced ROS generation, as well as RsAFP2 antifungal activity.	Ascorbic Acid	26-39	defensin-like protein 2	Raphanus sativus	47-53
17827975-7	2007	Moreover, the antioxidant ascorbic acid blocks RsAFP2-induced ROS generation, as well as RsAFP2 antifungal activity.	Ascorbic Acid	26-39	defensin-like protein 2	Raphanus sativus	89-95
17827975-7	2007	Moreover, the antioxidant ascorbic acid blocks RsAFP2-induced ROS generation, as well as RsAFP2 antifungal activity.	Reactive Oxygen Species	62-65	defensin-like protein 2	Raphanus sativus	47-53
8995418-5	1997	Two arginine substitution variants were found to be more active than wild-type Rs-AFP2 in media with high ionic strength.	Arginine	4-12	defensin-like protein 2	Raphanus sativus	79-86
22384976-0	2012	The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans.	Ceramides	95-104	defensin-like protein 2	Raphanus sativus	19-25
22384976-4	2012	Consistent with these genetic data, we demonstrated that RsAFP2 interacts with the cell wall of C. albicans, which also contains glucosylceramides, and activates the cell wall integrity pathway.	Glucosylceramides	129-146	defensin-like protein 2	Raphanus sativus	57-63
22384976-7	2012	Therefore, ceramide levels in C. albicans membranes were analysed following RsAFP2 treatment and, as expected, increased accumulation of phytoC24-ceramides in membranes of RsAFP2-treated C. albicans cells was detected.	Ceramides	11-19	defensin-like protein 2	Raphanus sativus	76-82
22384976-7	2012	Therefore, ceramide levels in C. albicans membranes were analysed following RsAFP2 treatment and, as expected, increased accumulation of phytoC24-ceramides in membranes of RsAFP2-treated C. albicans cells was detected.	Ceramides	11-19	defensin-like protein 2	Raphanus sativus	172-178
22384976-7	2012	Therefore, ceramide levels in C. albicans membranes were analysed following RsAFP2 treatment and, as expected, increased accumulation of phytoC24-ceramides in membranes of RsAFP2-treated C. albicans cells was detected.	phytoc24-ceramides	137-155	defensin-like protein 2	Raphanus sativus	172-178