PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
20410832-4	2010	Among the 3 different subtypes of K(ATP) channels heterologously expressed in human embryonic kidney cells and Xenopus oocytes, iptakalim exhibits significant selectivity for SUR2B/Kir6.1 channels, mild effects on SUR2A/Kir6.2 channels, and fails to open SUR1/Kir6.2 channels.	N-(1-methylethyl)-1,1,2-trimethylpropylamine	128-137	potassium inwardly rectifying channel subfamily J member 8 L homeolog	Xenopus laevis	181-187
26725741-8	2016	Moreover, the residues (K707 and K1348) within the Walker A (WA) motifs of two nucleotide-binding domains (NBDs) were essential for SUR2B/Kir6.x (especially SUR2B/Kir6.1) channel activation by Na-azide, suggesting a key role for Mg-adenine nucleotide binding and/or hydrolysis in the SUR2B subunit.	na-azide	193-201	potassium inwardly rectifying channel subfamily J member 8 L homeolog	Xenopus laevis	163-169
26725741-8	2016	Moreover, the residues (K707 and K1348) within the Walker A (WA) motifs of two nucleotide-binding domains (NBDs) were essential for SUR2B/Kir6.x (especially SUR2B/Kir6.1) channel activation by Na-azide, suggesting a key role for Mg-adenine nucleotide binding and/or hydrolysis in the SUR2B subunit.	mg-adenine nucleotide	229-250	potassium inwardly rectifying channel subfamily J member 8 L homeolog	Xenopus laevis	163-169
17239259-9	2007	Also, stimulations of P2Y receptor by UTP or PKC by PDBu markedly depressed the K(+)-current response to KCOs in favor of Kir6.1, as previously observed with the responses to FSH and Ade.	Uridine Triphosphate	38-41	potassium inwardly rectifying channel subfamily J member 8 L homeolog	Xenopus laevis	122-128
17522344-10	2007	Finally, iptakalim inhibited Kir6.2/SUR1, but it activated Kir6.1/SUR2B (vascular-type), K(ATP) channels heterologously expressed in Xenopus oocytes.	N-(1-methylethyl)-1,1,2-trimethylpropylamine	9-18	potassium inwardly rectifying channel subfamily J member 8 L homeolog	Xenopus laevis	59-65
17239259-10	2007	These results suggest that the K(+)-current responses to FSH and Ade may be produced by the opening of a novel type of K(ATP) channel comprising SUR2A and Kir6.1.	Adenosine	65-68	potassium inwardly rectifying channel subfamily J member 8 L homeolog	Xenopus laevis	155-161
11788443-4	2002	Expression of Kir6.1 in Xenopus oocytes generated an additional K(+) current that was found to be sensitive to external barium and intracellular taurine and to changes in intracellular ATP concentrations.	Barium	120-126	potassium inwardly rectifying channel subfamily J member 8 L homeolog	Xenopus laevis	14-20
17239259-10	2007	These results suggest that the K(+)-current responses to FSH and Ade may be produced by the opening of a novel type of K(ATP) channel comprising SUR2A and Kir6.1.	Adenosine Triphosphate	121-124	potassium inwardly rectifying channel subfamily J member 8 L homeolog	Xenopus laevis	155-161
11788443-4	2002	Expression of Kir6.1 in Xenopus oocytes generated an additional K(+) current that was found to be sensitive to external barium and intracellular taurine and to changes in intracellular ATP concentrations.	Taurine	145-152	potassium inwardly rectifying channel subfamily J member 8 L homeolog	Xenopus laevis	14-20
11788443-4	2002	Expression of Kir6.1 in Xenopus oocytes generated an additional K(+) current that was found to be sensitive to external barium and intracellular taurine and to changes in intracellular ATP concentrations.	Adenosine Triphosphate	185-188	potassium inwardly rectifying channel subfamily J member 8 L homeolog	Xenopus laevis	14-20
9023770-5	1997	Oocytes injected with SUR1 and either Kir6.2 or Kir6.1 exhibited large inwardly rectifying K+ currents when cytosolic ATP levels were lowered by the metabolic inhibitors azide or FCCP.	Adenosine Triphosphate	118-121	potassium inwardly rectifying channel subfamily J member 8 L homeolog	Xenopus laevis	48-54
9023770-5	1997	Oocytes injected with SUR1 and either Kir6.2 or Kir6.1 exhibited large inwardly rectifying K+ currents when cytosolic ATP levels were lowered by the metabolic inhibitors azide or FCCP.	Azides	170-175	potassium inwardly rectifying channel subfamily J member 8 L homeolog	Xenopus laevis	48-54
9023770-5	1997	Oocytes injected with SUR1 and either Kir6.2 or Kir6.1 exhibited large inwardly rectifying K+ currents when cytosolic ATP levels were lowered by the metabolic inhibitors azide or FCCP.	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	179-183	potassium inwardly rectifying channel subfamily J member 8 L homeolog	Xenopus laevis	48-54