PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
9017510-7	1996	Analysis of Western blots using polyclonal antibodies to OSBP showed that specific [3H]25-OH chol binding in the absence of LY295427 was present only in fractions containing OSBP.	Tritium	84-86	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	57-61
9869656-0	1999	Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol.	Sphingomyelins	110-123	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	47-72
9869656-0	1999	Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol.	Sphingomyelins	110-123	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	74-78
9869656-0	1999	Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol.	25-hydroxycholesterol	139-160	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	47-72
9869656-0	1999	Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol.	25-hydroxycholesterol	139-160	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	74-78
9869656-3	1999	The role of oxysterol binding protein (OSBP), a high affinity receptor for 25-hydroxycholesterol, in activation of SM synthesis was assessed by overexpression in CHO-K1 cells.	25-hydroxycholesterol	75-96	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	12-37
9869656-3	1999	The role of oxysterol binding protein (OSBP), a high affinity receptor for 25-hydroxycholesterol, in activation of SM synthesis was assessed by overexpression in CHO-K1 cells.	25-hydroxycholesterol	75-96	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	39-43
9869656-3	1999	The role of oxysterol binding protein (OSBP), a high affinity receptor for 25-hydroxycholesterol, in activation of SM synthesis was assessed by overexpression in CHO-K1 cells.	Samarium	115-117	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	12-37
9869656-3	1999	The role of oxysterol binding protein (OSBP), a high affinity receptor for 25-hydroxycholesterol, in activation of SM synthesis was assessed by overexpression in CHO-K1 cells.	Samarium	115-117	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	39-43
9869656-4	1999	When compared to mock transfected controls, three CHO-K1 clones overexpressing OSBP by 10- to 15-fold displayed a 2- to 3-fold enhancement of [3H]serine incorporation into sphingomyelin when treated with 25-hydroxycholesterol.	Tritium	143-145	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	79-83
9869656-4	1999	When compared to mock transfected controls, three CHO-K1 clones overexpressing OSBP by 10- to 15-fold displayed a 2- to 3-fold enhancement of [3H]serine incorporation into sphingomyelin when treated with 25-hydroxycholesterol.	Serine	146-152	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	79-83
9869656-4	1999	When compared to mock transfected controls, three CHO-K1 clones overexpressing OSBP by 10- to 15-fold displayed a 2- to 3-fold enhancement of [3H]serine incorporation into sphingomyelin when treated with 25-hydroxycholesterol.	Sphingomyelins	172-185	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	79-83
9869656-4	1999	When compared to mock transfected controls, three CHO-K1 clones overexpressing OSBP by 10- to 15-fold displayed a 2- to 3-fold enhancement of [3H]serine incorporation into sphingomyelin when treated with 25-hydroxycholesterol.	25-hydroxycholesterol	204-225	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	79-83
9869656-5	1999	Closer examination of one of these clones (CHO-OSBP cells) revealed a >8.5-fold stimulation of sphingomyelin synthesis after a 6-h treatment with 25-hydroxycholesterol compared to 3.5-fold in controls, slightly higher basal levels of sphingomyelin synthesis, and a more rapid response to 25-hydroxycholesterol.	cho	43-46	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	47-51
9869656-5	1999	Closer examination of one of these clones (CHO-OSBP cells) revealed a >8.5-fold stimulation of sphingomyelin synthesis after a 6-h treatment with 25-hydroxycholesterol compared to 3.5-fold in controls, slightly higher basal levels of sphingomyelin synthesis, and a more rapid response to 25-hydroxycholesterol.	Sphingomyelins	98-111	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	47-51
9869656-5	1999	Closer examination of one of these clones (CHO-OSBP cells) revealed a >8.5-fold stimulation of sphingomyelin synthesis after a 6-h treatment with 25-hydroxycholesterol compared to 3.5-fold in controls, slightly higher basal levels of sphingomyelin synthesis, and a more rapid response to 25-hydroxycholesterol.	25-hydroxycholesterol	149-170	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	47-51
9869656-5	1999	Closer examination of one of these clones (CHO-OSBP cells) revealed a >8.5-fold stimulation of sphingomyelin synthesis after a 6-h treatment with 25-hydroxycholesterol compared to 3.5-fold in controls, slightly higher basal levels of sphingomyelin synthesis, and a more rapid response to 25-hydroxycholesterol.	Sphingomyelins	237-250	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	47-51
9869656-5	1999	Closer examination of one of these clones (CHO-OSBP cells) revealed a >8.5-fold stimulation of sphingomyelin synthesis after a 6-h treatment with 25-hydroxycholesterol compared to 3.5-fold in controls, slightly higher basal levels of sphingomyelin synthesis, and a more rapid response to 25-hydroxycholesterol.	25-hydroxycholesterol	291-312	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	47-51
9813079-0	1998	Differential effects of sphingomyelin hydrolysis and cholesterol transport on oxysterol-binding protein phosphorylation and Golgi localization.	Sphingomyelins	24-37	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	78-103
9813079-0	1998	Differential effects of sphingomyelin hydrolysis and cholesterol transport on oxysterol-binding protein phosphorylation and Golgi localization.	Cholesterol	53-64	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	78-103
9813079-3	1998	After sphingomyelinase treatment, restoration of OSBP phosphorylation closely paralleled resynthesis of SM and down-regulation of cholesterol ester synthesis.	Cholesterol Esters	130-147	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	49-53
9813079-7	1998	Cyclodextrin and U18666A also caused OSBP translocation to the Golgi apparatus, suggesting that OSBP movement is coupled to changes in the cholesterol content of the plasma membrane or Golgi apparatus.	Cyclodextrins	0-12	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	37-41
9813079-7	1998	Cyclodextrin and U18666A also caused OSBP translocation to the Golgi apparatus, suggesting that OSBP movement is coupled to changes in the cholesterol content of the plasma membrane or Golgi apparatus.	Cyclodextrins	0-12	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	96-100
9813079-7	1998	Cyclodextrin and U18666A also caused OSBP translocation to the Golgi apparatus, suggesting that OSBP movement is coupled to changes in the cholesterol content of the plasma membrane or Golgi apparatus.	3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one	17-24	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	37-41
9813079-7	1998	Cyclodextrin and U18666A also caused OSBP translocation to the Golgi apparatus, suggesting that OSBP movement is coupled to changes in the cholesterol content of the plasma membrane or Golgi apparatus.	3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one	17-24	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	96-100
9813079-7	1998	Cyclodextrin and U18666A also caused OSBP translocation to the Golgi apparatus, suggesting that OSBP movement is coupled to changes in the cholesterol content of the plasma membrane or Golgi apparatus.	Cholesterol	139-150	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	96-100
9813079-8	1998	These results identify OSBP as a potential target of SM turnover and cholesterol mobilization at the plasma membrane and/or Golgi apparatus.	Cholesterol	69-80	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	23-27
9487139-5	1998	[32P]Phosphate pulse-chase and immunoprecipitation experiments showed that BFA inhibited phosphorylation of OSBP, but not its rate of dephosphorylation.	Brefeldin A	75-78	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	108-112
9487139-8	1998	OSBP was phosphorylated in vitro by the Golgi enriched fraction of CHO-K1 cells or rat liver by a staurosporine- and BFA-insensitive kinase.	Staurosporine	98-111	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-4
9487139-8	1998	OSBP was phosphorylated in vitro by the Golgi enriched fraction of CHO-K1 cells or rat liver by a staurosporine- and BFA-insensitive kinase.	Brefeldin A	117-120	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-4
9487139-10	1998	Furthermore, dephosphorylation of OSBP by staurosporine did not affect 25-hydroxycholesterol-mediated localization to the Golgi apparatus.	Staurosporine	42-55	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	34-38
9337870-0	1997	Altered regulation of cholesterol and cholesteryl ester synthesis in Chinese-hamster ovary cells overexpressing the oxysterol-binding protein is dependent on the pleckstrin homology domain.	Cholesterol	22-33	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	116-141
9337870-0	1997	Altered regulation of cholesterol and cholesteryl ester synthesis in Chinese-hamster ovary cells overexpressing the oxysterol-binding protein is dependent on the pleckstrin homology domain.	Cholesterol Esters	38-55	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	116-141
9337870-1	1997	Oxysterol-binding protein (OSBP) is a high-affinity receptor for a variety of oxysterols, such as 25-hydroxycholesterol, that down-regulate cholesterol synthesis and stimulate cholesterol esterification.	Oxysterols	78-88	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-25
9337870-1	1997	Oxysterol-binding protein (OSBP) is a high-affinity receptor for a variety of oxysterols, such as 25-hydroxycholesterol, that down-regulate cholesterol synthesis and stimulate cholesterol esterification.	Oxysterols	78-88	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	27-31
9337870-1	1997	Oxysterol-binding protein (OSBP) is a high-affinity receptor for a variety of oxysterols, such as 25-hydroxycholesterol, that down-regulate cholesterol synthesis and stimulate cholesterol esterification.	25-hydroxycholesterol	98-119	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-25
9337870-1	1997	Oxysterol-binding protein (OSBP) is a high-affinity receptor for a variety of oxysterols, such as 25-hydroxycholesterol, that down-regulate cholesterol synthesis and stimulate cholesterol esterification.	25-hydroxycholesterol	98-119	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	27-31
9337870-1	1997	Oxysterol-binding protein (OSBP) is a high-affinity receptor for a variety of oxysterols, such as 25-hydroxycholesterol, that down-regulate cholesterol synthesis and stimulate cholesterol esterification.	Cholesterol	108-119	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-25
9337870-1	1997	Oxysterol-binding protein (OSBP) is a high-affinity receptor for a variety of oxysterols, such as 25-hydroxycholesterol, that down-regulate cholesterol synthesis and stimulate cholesterol esterification.	Cholesterol	108-119	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	27-31
9337870-1	1997	Oxysterol-binding protein (OSBP) is a high-affinity receptor for a variety of oxysterols, such as 25-hydroxycholesterol, that down-regulate cholesterol synthesis and stimulate cholesterol esterification.	Cholesterol	140-151	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-25
9337870-1	1997	Oxysterol-binding protein (OSBP) is a high-affinity receptor for a variety of oxysterols, such as 25-hydroxycholesterol, that down-regulate cholesterol synthesis and stimulate cholesterol esterification.	Cholesterol	140-151	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	27-31
9337870-2	1997	To examine a potential role for OSBP in regulating cholesterol metabolism, we stably overexpressed this protein in Chinese-hamster ovary (CHO)-K1 cells.	Cholesterol	51-62	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	32-36
9337870-3	1997	Compared with mock-transfected controls, several cell lines overexpressing wild-type OSBP (CHO-OSBP) displayed a 50% decrease in cholesteryl ester synthesis when cultured in medium with delipidated serum, 25-hydroxycholesterol or low-density lipoprotein (LDL).	Cholesterol Esters	129-146	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	85-89
11861666-0	2002	ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism.	Cholesterol	65-76	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	19-44
11441133-1	2001	Oxysterol binding protein (OSBP) translocation between Golgi and vesicular/cytoplasmic compartments is affected by conditions that alter cholesterol and sphingomyelin homeostasis, indicating a role in lipid and sterol regulation in this organelle.	Cholesterol	137-148	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-25
11441133-1	2001	Oxysterol binding protein (OSBP) translocation between Golgi and vesicular/cytoplasmic compartments is affected by conditions that alter cholesterol and sphingomyelin homeostasis, indicating a role in lipid and sterol regulation in this organelle.	Cholesterol	137-148	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	27-31
11441133-1	2001	Oxysterol binding protein (OSBP) translocation between Golgi and vesicular/cytoplasmic compartments is affected by conditions that alter cholesterol and sphingomyelin homeostasis, indicating a role in lipid and sterol regulation in this organelle.	Sterols	3-9	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	27-31
11441133-2	2001	In this study, we show that OSBP dissociation from the Golgi apparatus was inhibited when LDL cholesterol efflux from lysosomes was blocked in Niemann-Pick C (NPC) or U18666A [3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one]-treated fibroblasts.	Cholesterol	94-105	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	28-32
11441133-2	2001	In this study, we show that OSBP dissociation from the Golgi apparatus was inhibited when LDL cholesterol efflux from lysosomes was blocked in Niemann-Pick C (NPC) or U18666A [3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one]-treated fibroblasts.	3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one	167-174	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	28-32
11441133-2	2001	In this study, we show that OSBP dissociation from the Golgi apparatus was inhibited when LDL cholesterol efflux from lysosomes was blocked in Niemann-Pick C (NPC) or U18666A [3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one]-treated fibroblasts.	3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one	176-226	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	28-32
11441133-5	2001	However, OSBP in the Golgi apparatus was progressively dephosphorylated (as assessed by a molecular mass shift on SDS-PAGE) in U18666A-treated fibroblasts or Chinese hamster ovary cells as a result of combined inhibition of LDL cholesterol transport and de novo cholesterol synthesis.	Sodium Dodecyl Sulfate	114-117	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	9-13
11441133-5	2001	However, OSBP in the Golgi apparatus was progressively dephosphorylated (as assessed by a molecular mass shift on SDS-PAGE) in U18666A-treated fibroblasts or Chinese hamster ovary cells as a result of combined inhibition of LDL cholesterol transport and de novo cholesterol synthesis.	Cholesterol	228-239	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	9-13
11441133-5	2001	However, OSBP in the Golgi apparatus was progressively dephosphorylated (as assessed by a molecular mass shift on SDS-PAGE) in U18666A-treated fibroblasts or Chinese hamster ovary cells as a result of combined inhibition of LDL cholesterol transport and de novo cholesterol synthesis.	Cholesterol	262-273	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	9-13
11441133-6	2001	In vivo phosphopeptide mapping and mutagenesis of OSBP was used to identify the cholesterol-sensitive phosphorylation sites at serines 381, 384, and 387 that were responsible for the altered mobility on SDS-PAGE.	Cholesterol	80-91	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	50-54
11441133-6	2001	In vivo phosphopeptide mapping and mutagenesis of OSBP was used to identify the cholesterol-sensitive phosphorylation sites at serines 381, 384, and 387 that were responsible for the altered mobility on SDS-PAGE.	Serine	127-134	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	50-54
11441133-6	2001	In vivo phosphopeptide mapping and mutagenesis of OSBP was used to identify the cholesterol-sensitive phosphorylation sites at serines 381, 384, and 387 that were responsible for the altered mobility on SDS-PAGE.	Sodium Dodecyl Sulfate	203-206	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	50-54
11441133-7	2001	NPC-1 protein-mediated release of LDL-derived cholesterol and de novo biosynthesis regulates OSBP localization and phosphorylation.	Cholesterol	46-57	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	93-97
11441133-8	2001	This indicates that OSBP responds to or senses altered cellular sterol content and transport.	Sterols	64-70	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	20-24
9869656-11	1999	Results from overexpressing cells show that OSBP potentiates the stimulatory effects of 25-hydroxycholesterol on sphingomyelin synthesis.	25-hydroxycholesterol	88-109	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	44-48
9869656-11	1999	Results from overexpressing cells show that OSBP potentiates the stimulatory effects of 25-hydroxycholesterol on sphingomyelin synthesis.	Sphingomyelins	113-126	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	44-48
9869656-12	1999	25-Hydroxycholesterol promotes translocation of OSBP to the Golgi apparatus where it appears to stimulate conversion of ceramide to sphingomyelin.	25-hydroxycholesterol	0-21	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	48-52
9869656-12	1999	25-Hydroxycholesterol promotes translocation of OSBP to the Golgi apparatus where it appears to stimulate conversion of ceramide to sphingomyelin.	Ceramides	120-128	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	48-52
9869656-12	1999	25-Hydroxycholesterol promotes translocation of OSBP to the Golgi apparatus where it appears to stimulate conversion of ceramide to sphingomyelin.	Sphingomyelins	132-145	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	48-52
9806908-0	1998	Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25-hydroxycholesterol.	Cholesterol	0-11	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	22-47
9806908-0	1998	Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25-hydroxycholesterol.	Cholesterol	0-11	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	49-53
9806908-0	1998	Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25-hydroxycholesterol.	Sphingomyelins	158-171	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	49-53
9806908-0	1998	Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25-hydroxycholesterol.	25-hydroxycholesterol	185-206	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	49-53
9806908-2	1998	The potential role of oxysterols and oxysterol binding protein (OSBP) in mediating the coregulation of cholesterol and SM was examined using Chinese hamster ovary (CHO) and cholesterol auxotrophic, sterol regulatory defective (SRD) 6 cells.	Cholesterol	103-114	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	37-62
9806908-2	1998	The potential role of oxysterols and oxysterol binding protein (OSBP) in mediating the coregulation of cholesterol and SM was examined using Chinese hamster ovary (CHO) and cholesterol auxotrophic, sterol regulatory defective (SRD) 6 cells.	Cholesterol	103-114	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	64-68
9806908-2	1998	The potential role of oxysterols and oxysterol binding protein (OSBP) in mediating the coregulation of cholesterol and SM was examined using Chinese hamster ovary (CHO) and cholesterol auxotrophic, sterol regulatory defective (SRD) 6 cells.	Cholesterol	173-184	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	64-68
9806908-6	1998	Lack of 25-hydroxycholesterol activation of SM synthesis in cholesterol-starved SRD 6 and lovastatin-treated CHO-K1 cells was correlated with dephosphorylation of OSBP.	Lovastatin	90-100	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	163-167
9806908-8	1998	Unlike CHO 7 cells, where OSBP was observed in small vesicles and the cytoplasm, OSBP in cholesterol-starved SRD 6 cells was constitutively localized in the Golgi apparatus.	Cholesterol	89-100	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	81-85
9806908-11	1998	Low-density lipoprotein (LDL) supplementation of CHO-K1 cells caused the redistribution of OSBP to the cytoplasm and small vesicles, and this effect was blocked by pharmacological agents ?3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one and progesterone?, which inhibited LDL cholesterol efflux from lysosomes.	3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one	188-238	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	91-95
9806908-11	1998	Low-density lipoprotein (LDL) supplementation of CHO-K1 cells caused the redistribution of OSBP to the cytoplasm and small vesicles, and this effect was blocked by pharmacological agents ?3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one and progesterone?, which inhibited LDL cholesterol efflux from lysosomes.	Progesterone	243-255	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	91-95
9806908-11	1998	Low-density lipoprotein (LDL) supplementation of CHO-K1 cells caused the redistribution of OSBP to the cytoplasm and small vesicles, and this effect was blocked by pharmacological agents ?3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one and progesterone?, which inhibited LDL cholesterol efflux from lysosomes.	Cholesterol	278-289	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	91-95
9806908-12	1998	The results showed that localization of OSBP between the Golgi apparatus and a cytoplasmic/vesicular compartment was responsive to changes in cholesterol content and trafficking.	Cholesterol	142-153	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	40-44
9806908-13	1998	In cholesterol depleted SRD 6 cells, this was accompanied by dephosphorylation of OSBP and attenuation of 25-hydroxycholesterol activation of SM synthesis.	Cholesterol	3-14	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	82-86
9487139-0	1998	Inhibition of phosphorylation of the oxysterol binding protein by brefeldin A.	Brefeldin A	66-77	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	37-62
9487139-1	1998	Oxysterol binding protein (OSBP), a high affinity receptor for 25-hydroxycholesterol that localizes to a Golgi/vesicular compartment, migrated on SDS-PAGE as a doublet of 96 and 101 kDa.	25-hydroxycholesterol	63-84	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-25
9487139-1	1998	Oxysterol binding protein (OSBP), a high affinity receptor for 25-hydroxycholesterol that localizes to a Golgi/vesicular compartment, migrated on SDS-PAGE as a doublet of 96 and 101 kDa.	25-hydroxycholesterol	63-84	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	27-31
9487139-1	1998	Oxysterol binding protein (OSBP), a high affinity receptor for 25-hydroxycholesterol that localizes to a Golgi/vesicular compartment, migrated on SDS-PAGE as a doublet of 96 and 101 kDa.	Sodium Dodecyl Sulfate	146-149	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-25
9487139-1	1998	Oxysterol binding protein (OSBP), a high affinity receptor for 25-hydroxycholesterol that localizes to a Golgi/vesicular compartment, migrated on SDS-PAGE as a doublet of 96 and 101 kDa.	Sodium Dodecyl Sulfate	146-149	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	27-31
9487139-4	1998	Treatment of overexpressing and control cells with brefeldin A (BFA) caused dephosphorylation of OSBP that coincided with disruption of the Golgi apparatus.	Brefeldin A	51-62	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	97-101
9487139-4	1998	Treatment of overexpressing and control cells with brefeldin A (BFA) caused dephosphorylation of OSBP that coincided with disruption of the Golgi apparatus.	Brefeldin A	64-67	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	97-101
9337870-3	1997	Compared with mock-transfected controls, several cell lines overexpressing wild-type OSBP (CHO-OSBP) displayed a 50% decrease in cholesteryl ester synthesis when cultured in medium with delipidated serum, 25-hydroxycholesterol or low-density lipoprotein (LDL).	Cholesterol Esters	129-146	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	91-99
9337870-3	1997	Compared with mock-transfected controls, several cell lines overexpressing wild-type OSBP (CHO-OSBP) displayed a 50% decrease in cholesteryl ester synthesis when cultured in medium with delipidated serum, 25-hydroxycholesterol or low-density lipoprotein (LDL).	25-hydroxycholesterol	205-226	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	85-89
9337870-3	1997	Compared with mock-transfected controls, several cell lines overexpressing wild-type OSBP (CHO-OSBP) displayed a 50% decrease in cholesteryl ester synthesis when cultured in medium with delipidated serum, 25-hydroxycholesterol or low-density lipoprotein (LDL).	25-hydroxycholesterol	205-226	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	91-99
9337870-4	1997	CHO-OSBP cells showed a 40-60% decrease in acyl-CoA:cholesterol acyltransferase activity and mRNA, a 50% elevation in mRNA for three sterol-regulated genes [LDL receptor, 3-hydroxy-3-methylgluraryl (HMG)-CoA reductase and HMG-CoA synthase], and an 80% increase in [14C]acetate incorporation into cholesterol.	Carbon-14	265-268	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-8
9337870-4	1997	CHO-OSBP cells showed a 40-60% decrease in acyl-CoA:cholesterol acyltransferase activity and mRNA, a 50% elevation in mRNA for three sterol-regulated genes [LDL receptor, 3-hydroxy-3-methylgluraryl (HMG)-CoA reductase and HMG-CoA synthase], and an 80% increase in [14C]acetate incorporation into cholesterol.	Acetates	269-276	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-8
9337870-4	1997	CHO-OSBP cells showed a 40-60% decrease in acyl-CoA:cholesterol acyltransferase activity and mRNA, a 50% elevation in mRNA for three sterol-regulated genes [LDL receptor, 3-hydroxy-3-methylgluraryl (HMG)-CoA reductase and HMG-CoA synthase], and an 80% increase in [14C]acetate incorporation into cholesterol.	Cholesterol	52-63	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-8
9337870-5	1997	CHO-K1 cells overexpressing two OSBP mutants with a complete or N-terminal deletion of the pleckstrin homology (PH) domain had cholesterol esterification and synthesis rates that were similar to those shown by mock-transfected controls.	Cholesterol	127-138	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	32-36
9337870-7	1997	CHO-K1 cells overexpressing OSBP have pronounced alterations in cholesterol esterification and synthesis, indicating a potential role for this receptor in cholesterol homoeostasis.	Cholesterol	64-75	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	28-32
9017510-7	1996	Analysis of Western blots using polyclonal antibodies to OSBP showed that specific [3H]25-OH chol binding in the absence of LY295427 was present only in fractions containing OSBP.	25-oh	87-92	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	57-61
9017510-7	1996	Analysis of Western blots using polyclonal antibodies to OSBP showed that specific [3H]25-OH chol binding in the absence of LY295427 was present only in fractions containing OSBP.	chol	93-97	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	57-61
9017510-8	1996	However, enhanced [3H]25-OH chol binding in the presence of LY295427 was evident in distinct fractions after immunodepletion of both the 90-100 kDa form of OSBP and a 170 kDa protein; and specific binding of a radioiodinated analog of LY295427 was detected in select fractions lacking [3H]25-OH chol binding in the absence of LY295427.	Tritium	19-21	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	156-160
9017510-8	1996	However, enhanced [3H]25-OH chol binding in the presence of LY295427 was evident in distinct fractions after immunodepletion of both the 90-100 kDa form of OSBP and a 170 kDa protein; and specific binding of a radioiodinated analog of LY295427 was detected in select fractions lacking [3H]25-OH chol binding in the absence of LY295427.	25-oh chol	22-32	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	156-160
9017510-8	1996	However, enhanced [3H]25-OH chol binding in the presence of LY295427 was evident in distinct fractions after immunodepletion of both the 90-100 kDa form of OSBP and a 170 kDa protein; and specific binding of a radioiodinated analog of LY295427 was detected in select fractions lacking [3H]25-OH chol binding in the absence of LY295427.	LY 295427	60-68	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	156-160
9017510-8	1996	However, enhanced [3H]25-OH chol binding in the presence of LY295427 was evident in distinct fractions after immunodepletion of both the 90-100 kDa form of OSBP and a 170 kDa protein; and specific binding of a radioiodinated analog of LY295427 was detected in select fractions lacking [3H]25-OH chol binding in the absence of LY295427.	25-oh	22-27	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	156-160
9017510-8	1996	However, enhanced [3H]25-OH chol binding in the presence of LY295427 was evident in distinct fractions after immunodepletion of both the 90-100 kDa form of OSBP and a 170 kDa protein; and specific binding of a radioiodinated analog of LY295427 was detected in select fractions lacking [3H]25-OH chol binding in the absence of LY295427.	chol	28-32	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	156-160
22875984-0	2012	Multisite phosphorylation of oxysterol-binding protein regulates sterol binding and activation of sphingomyelin synthesis.	Sphingomyelins	98-111	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	29-54
26601944-0	2016	Oxysterol-binding Protein Activation at Endoplasmic Reticulum-Golgi Contact Sites Reorganizes Phosphatidylinositol 4-Phosphate Pools.	phosphatidylinositol 4-phosphate	94-126	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-25
26601944-1	2016	Oxysterol-binding protein (OSBP) exchanges cholesterol and phosphatidylinositol 4-phosphate (PI-4P) at contact sites between the endoplasmic reticulum (ER) and the trans-Golgi/trans-Golgi network.	Cholesterol	43-54	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-25
26601944-1	2016	Oxysterol-binding protein (OSBP) exchanges cholesterol and phosphatidylinositol 4-phosphate (PI-4P) at contact sites between the endoplasmic reticulum (ER) and the trans-Golgi/trans-Golgi network.	Cholesterol	43-54	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	27-31
26601944-1	2016	Oxysterol-binding protein (OSBP) exchanges cholesterol and phosphatidylinositol 4-phosphate (PI-4P) at contact sites between the endoplasmic reticulum (ER) and the trans-Golgi/trans-Golgi network.	phosphatidylinositol 4-phosphate	59-91	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-25
26601944-1	2016	Oxysterol-binding protein (OSBP) exchanges cholesterol and phosphatidylinositol 4-phosphate (PI-4P) at contact sites between the endoplasmic reticulum (ER) and the trans-Golgi/trans-Golgi network.	phosphatidylinositol 4-phosphate	59-91	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	27-31
26601944-2	2016	25-Hydroxycholesterol (25OH) competitively inhibits this exchange reaction in vitro and causes the constitutive localization of OSBP at the ER/Golgi interface and PI-4P-dependent recruitment of ceramide transfer protein (CERT) for sphingomyelin synthesis.	25-hydroxycholesterol	0-21	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	128-132
26601944-2	2016	25-Hydroxycholesterol (25OH) competitively inhibits this exchange reaction in vitro and causes the constitutive localization of OSBP at the ER/Golgi interface and PI-4P-dependent recruitment of ceramide transfer protein (CERT) for sphingomyelin synthesis.	25-hydroxycholesterol	23-27	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	128-132
26601944-2	2016	25-Hydroxycholesterol (25OH) competitively inhibits this exchange reaction in vitro and causes the constitutive localization of OSBP at the ER/Golgi interface and PI-4P-dependent recruitment of ceramide transfer protein (CERT) for sphingomyelin synthesis.	Sphingomyelins	231-244	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	128-132
26601944-4	2016	Treatment of fibroblasts or Chinese hamster ovary (CHO) cells with 25OH caused a 50-70% reduction in Golgi-associated immunoreactive PI-4P that correlated with Golgi localization of OSBP.	25-hydroxycholesterol	67-71	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	182-186
26601944-5	2016	In contrast, 25OH caused an OSBP-dependent enrichment in Golgi PI-4P that was detected with a pleckstrin homology domain probe.	25-hydroxycholesterol	13-17	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	28-32
26601944-7	2016	The PI-4P and sterol binding activities of OSBP were both required for 25OH activation of sphingomyelin synthesis, suggesting that 25OH must be exchanged for PI-4P to be concentrated at contact sites.	Sterols	14-20	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	43-47
26601944-7	2016	The PI-4P and sterol binding activities of OSBP were both required for 25OH activation of sphingomyelin synthesis, suggesting that 25OH must be exchanged for PI-4P to be concentrated at contact sites.	25-hydroxycholesterol	71-75	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	43-47
26601944-7	2016	The PI-4P and sterol binding activities of OSBP were both required for 25OH activation of sphingomyelin synthesis, suggesting that 25OH must be exchanged for PI-4P to be concentrated at contact sites.	Sphingomyelins	90-103	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	43-47
26601944-7	2016	The PI-4P and sterol binding activities of OSBP were both required for 25OH activation of sphingomyelin synthesis, suggesting that 25OH must be exchanged for PI-4P to be concentrated at contact sites.	25-hydroxycholesterol	131-135	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	43-47
26601944-8	2016	We propose a model wherein 25OH activation of OSBP promotes the binding and retention of PI-4P at ER-Golgi contact sites.	25-hydroxycholesterol	27-31	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	46-50
22875984-1	2012	The endoplasmic reticulum (ER)-Golgi sterol transfer activity of oxysterol-binding protein (OSBP) regulates sphingomyelin (SM) synthesis, as well as post-Golgi cholesterol efflux pathways.	Sphingomyelins	108-121	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	65-90
22875984-1	2012	The endoplasmic reticulum (ER)-Golgi sterol transfer activity of oxysterol-binding protein (OSBP) regulates sphingomyelin (SM) synthesis, as well as post-Golgi cholesterol efflux pathways.	Sphingomyelins	108-121	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	92-96
22875984-1	2012	The endoplasmic reticulum (ER)-Golgi sterol transfer activity of oxysterol-binding protein (OSBP) regulates sphingomyelin (SM) synthesis, as well as post-Golgi cholesterol efflux pathways.	Sphingomyelins	123-125	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	65-90
22875984-1	2012	The endoplasmic reticulum (ER)-Golgi sterol transfer activity of oxysterol-binding protein (OSBP) regulates sphingomyelin (SM) synthesis, as well as post-Golgi cholesterol efflux pathways.	Sphingomyelins	123-125	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	92-96
22875984-3	2012	In this paper, we report that phosphorylation on two serine-rich motifs, S381-S391 (site 1) and S192, S195, S200 (site 2), specifically controls OSBP activity at the ER.	Serine	53-59	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	145-149
22875984-4	2012	A phosphomimetic of the SM/cholesterol-sensitive phosphorylation site 1 (OSBP-S5E) had increased in vitro cholesterol and 25-hydroxycholesterol-binding capacity, and cholesterol extraction from liposomes, but reduced transfer activity.	Cholesterol	27-38	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	73-77
22875984-4	2012	A phosphomimetic of the SM/cholesterol-sensitive phosphorylation site 1 (OSBP-S5E) had increased in vitro cholesterol and 25-hydroxycholesterol-binding capacity, and cholesterol extraction from liposomes, but reduced transfer activity.	Cholesterol	106-117	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	73-77
22875984-4	2012	A phosphomimetic of the SM/cholesterol-sensitive phosphorylation site 1 (OSBP-S5E) had increased in vitro cholesterol and 25-hydroxycholesterol-binding capacity, and cholesterol extraction from liposomes, but reduced transfer activity.	Hydroxycholesterols	125-143	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	73-77
22875984-4	2012	A phosphomimetic of the SM/cholesterol-sensitive phosphorylation site 1 (OSBP-S5E) had increased in vitro cholesterol and 25-hydroxycholesterol-binding capacity, and cholesterol extraction from liposomes, but reduced transfer activity.	Cholesterol	106-117	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	73-77
22875984-5	2012	Phosphatidylinositol 4-phosphate (PI(4)P) and cholesterol competed for a common binding site on OSBP; however, direct binding of PI(4)P was not affected by site 1 phosphorylation.	phosphatidylinositol 4-phosphate	0-32	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	96-100
22875984-5	2012	Phosphatidylinositol 4-phosphate (PI(4)P) and cholesterol competed for a common binding site on OSBP; however, direct binding of PI(4)P was not affected by site 1 phosphorylation.	phosphatidylinositol 4-phosphate	34-40	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	96-100
22875984-5	2012	Phosphatidylinositol 4-phosphate (PI(4)P) and cholesterol competed for a common binding site on OSBP; however, direct binding of PI(4)P was not affected by site 1 phosphorylation.	Cholesterol	46-57	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	96-100
22875984-8	2012	This study identifies phosphorylation regulation of sterol and VAP-A binding by OSBP in the ER, and PI(4)P as an alternate ligand that could be exchanged for sterol in the Golgi apparatus.	Sterols	52-58	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	80-84
16571669-2	2006	One mechanism for regulation of this metabolic interface involves oxysterol binding protein (OSBP) via high-affinity binding to oxysterol regulators of cholesterol homeostasis and activation of SM synthesis at the Golgi apparatus.	Oxysterols	66-75	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	93-97
20881054-0	2010	Oxysterol binding protein-dependent activation of sphingomyelin synthesis in the golgi apparatus requires phosphatidylinositol 4-kinase IIalpha.	Sphingomyelins	50-63	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-25
20881054-0	2010	Oxysterol binding protein-dependent activation of sphingomyelin synthesis in the golgi apparatus requires phosphatidylinositol 4-kinase IIalpha.	Phosphatidylinositols	106-126	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-25
20881054-2	2010	One aspect of coordinate regulation occurs in the Golgi apparatus where oxysterol binding protein (OSBP) mediates sterol-dependent activation of ceramide transport protein (CERT) activity and SM synthesis.	Sterols	75-81	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	99-103
20881054-4	2010	Cell fractionation experiments revealed that Golgi/endosome-enriched membranes from 25-hydroxycholesterol-treated Chinese hamster ovary cells had increased activity of a sterol-sensitive PI4K that was blocked by small interfering RNA silencing of OSBP.	Hydroxycholesterols	87-105	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	247-251
20881054-4	2010	Cell fractionation experiments revealed that Golgi/endosome-enriched membranes from 25-hydroxycholesterol-treated Chinese hamster ovary cells had increased activity of a sterol-sensitive PI4K that was blocked by small interfering RNA silencing of OSBP.	Sterols	99-105	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	247-251
20881054-5	2010	Consistent with this sterol-requirement, OSBP silencing also reduced the cholesterol content of endosome/trans-Golgi network (TGN) fractions containing PI4KIIalpha.	Sterols	21-27	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	41-45
20881054-5	2010	Consistent with this sterol-requirement, OSBP silencing also reduced the cholesterol content of endosome/trans-Golgi network (TGN) fractions containing PI4KIIalpha.	Cholesterol	73-84	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	41-45
20881054-8	2010	The presence of OSBP, CERT, and PI4KIIalpha in the TGN of oxysterol-stimulated cells suggests that OSBP couples sterol binding or transfer activity with regulation of PI4KIIalpha activity, leading to CERT recruitment to the TGN and increased SM synthesis.	Oxysterols	58-67	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	16-20
20881054-8	2010	The presence of OSBP, CERT, and PI4KIIalpha in the TGN of oxysterol-stimulated cells suggests that OSBP couples sterol binding or transfer activity with regulation of PI4KIIalpha activity, leading to CERT recruitment to the TGN and increased SM synthesis.	Oxysterols	58-67	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	99-103
20881054-8	2010	The presence of OSBP, CERT, and PI4KIIalpha in the TGN of oxysterol-stimulated cells suggests that OSBP couples sterol binding or transfer activity with regulation of PI4KIIalpha activity, leading to CERT recruitment to the TGN and increased SM synthesis.	Sphingomyelins	242-244	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	99-103
18450749-3	2008	One potential regulator is OSBP (oxysterol-binding protein), which is implicated in the integration of sterol sensing/transport with sphingomyelin synthesis and cell signaling.	Sterols	36-42	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	27-31
18450749-3	2008	One potential regulator is OSBP (oxysterol-binding protein), which is implicated in the integration of sterol sensing/transport with sphingomyelin synthesis and cell signaling.	Sphingomyelins	133-146	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	27-31
18450749-3	2008	One potential regulator is OSBP (oxysterol-binding protein), which is implicated in the integration of sterol sensing/transport with sphingomyelin synthesis and cell signaling.	Sphingomyelins	133-146	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	33-58
18450749-5	2008	Suppression of OSBP in Chinese hamster ovary cells by RNA interference resulted in increased ABCA1 protein expression and cholesterol efflux activity following induction with oxysterols or the synthetic LXR agonist TO901317.	Cholesterol	122-133	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	15-19
18450749-5	2008	Suppression of OSBP in Chinese hamster ovary cells by RNA interference resulted in increased ABCA1 protein expression and cholesterol efflux activity following induction with oxysterols or the synthetic LXR agonist TO901317.	Oxysterols	175-185	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	15-19
18450749-9	2008	Sphingomyelin synthesis was suppressed in OSBP-depleted cells treated with 25-hydroxycholesterol but not TO901317 or 22-hydroxycholesterol and did not correlate with ABCA1 stabilization.	Sphingomyelins	0-13	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	42-46
18450749-9	2008	Sphingomyelin synthesis was suppressed in OSBP-depleted cells treated with 25-hydroxycholesterol but not TO901317 or 22-hydroxycholesterol and did not correlate with ABCA1 stabilization.	25-hydroxycholesterol	75-96	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	42-46
18450749-9	2008	Sphingomyelin synthesis was suppressed in OSBP-depleted cells treated with 25-hydroxycholesterol but not TO901317 or 22-hydroxycholesterol and did not correlate with ABCA1 stabilization.	T0901317	105-113	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	42-46
18450749-10	2008	Moreover, co-transfection experiments revealed that reduction of ABCA1 protein by OSBP was prevented by a mutation in the sterol-binding domain but not by mutations that abrogated interaction with the Golgi apparatus or endoplasmic reticulum.	Sterols	122-128	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	82-86
17350617-0	2007	Characterization of the sterol-binding domain of oxysterol-binding protein (OSBP)-related protein 4 reveals a novel role in vimentin organization.	Sterols	24-30	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	49-99
17350617-1	2007	Oxysterol-binding protein (OSBP) and OSBP-related protein 4 (ORP4; also designated OSBP2 and HLM) are implicated in sterol-transport and/or sensing via binding to protein partners.	Sterols	3-9	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	27-31
16571669-2	2006	One mechanism for regulation of this metabolic interface involves oxysterol binding protein (OSBP) via high-affinity binding to oxysterol regulators of cholesterol homeostasis and activation of SM synthesis at the Golgi apparatus.	Cholesterol	152-163	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	66-91
16571669-2	2006	One mechanism for regulation of this metabolic interface involves oxysterol binding protein (OSBP) via high-affinity binding to oxysterol regulators of cholesterol homeostasis and activation of SM synthesis at the Golgi apparatus.	Cholesterol	152-163	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	93-97
16571669-4	2006	RNA interference (RNAi) experiments in Chinese hamster ovary (CHO)-K1 cells revealed that OSBP and vesicle-associated membrane protein-associated protein (VAP) were required for stimulation of CERT-dependent ceramide transport and SM synthesis by 25-hydroxycholesterol and cholesterol depletion in response to cyclodextrin.	Ceramides	208-216	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	90-94
16571669-4	2006	RNA interference (RNAi) experiments in Chinese hamster ovary (CHO)-K1 cells revealed that OSBP and vesicle-associated membrane protein-associated protein (VAP) were required for stimulation of CERT-dependent ceramide transport and SM synthesis by 25-hydroxycholesterol and cholesterol depletion in response to cyclodextrin.	25-hydroxycholesterol	247-268	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	90-94
16571669-4	2006	RNA interference (RNAi) experiments in Chinese hamster ovary (CHO)-K1 cells revealed that OSBP and vesicle-associated membrane protein-associated protein (VAP) were required for stimulation of CERT-dependent ceramide transport and SM synthesis by 25-hydroxycholesterol and cholesterol depletion in response to cyclodextrin.	Cholesterol	257-268	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	90-94
16571669-4	2006	RNA interference (RNAi) experiments in Chinese hamster ovary (CHO)-K1 cells revealed that OSBP and vesicle-associated membrane protein-associated protein (VAP) were required for stimulation of CERT-dependent ceramide transport and SM synthesis by 25-hydroxycholesterol and cholesterol depletion in response to cyclodextrin.	Cyclodextrins	310-322	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	90-94
16571669-6	2006	Activation of ER-to-Golgi ceramide transport in CHO-K1 cells required interaction of OSBP with the ER and Golgi apparatus, OSBP-dependent Golgi translocation of CERT, and enhanced CERT-VAP interaction.	Ceramides	26-34	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	85-89
16571669-6	2006	Activation of ER-to-Golgi ceramide transport in CHO-K1 cells required interaction of OSBP with the ER and Golgi apparatus, OSBP-dependent Golgi translocation of CERT, and enhanced CERT-VAP interaction.	Ceramides	26-34	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	123-127
16571669-7	2006	Regulation of CERT by OSBP, sterols, and VAP reveals a novel mechanism for integrating sterol regulatory signals with ceramide transport and SM synthesis in the Golgi apparatus.	Ceramides	118-126	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	22-26
16571669-7	2006	Regulation of CERT by OSBP, sterols, and VAP reveals a novel mechanism for integrating sterol regulatory signals with ceramide transport and SM synthesis in the Golgi apparatus.	Sphingomyelins	141-143	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	22-26