PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
25662616-8	2015	MUPP1-PDZ4 protein was a monomer with a molar mass of 16.4 kDa in solution and had a melting point of 60.3 C. Using the sitting-drop vapor-diffusion method, MUPP1-PDZ4 protein crystals were obtained in a solution (pH 7.0) containing 2% (v/v) polyethylene glycol 400, 0.1 M imidazole, and 24% (w/v) polyethylene glycol monoethyl ether 5000.	polyethylene glycol 400	242-265	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	0-5
25662616-8	2015	MUPP1-PDZ4 protein was a monomer with a molar mass of 16.4 kDa in solution and had a melting point of 60.3 C. Using the sitting-drop vapor-diffusion method, MUPP1-PDZ4 protein crystals were obtained in a solution (pH 7.0) containing 2% (v/v) polyethylene glycol 400, 0.1 M imidazole, and 24% (w/v) polyethylene glycol monoethyl ether 5000.	polyethylene glycol 400	242-265	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	0-10
25662616-8	2015	MUPP1-PDZ4 protein was a monomer with a molar mass of 16.4 kDa in solution and had a melting point of 60.3 C. Using the sitting-drop vapor-diffusion method, MUPP1-PDZ4 protein crystals were obtained in a solution (pH 7.0) containing 2% (v/v) polyethylene glycol 400, 0.1 M imidazole, and 24% (w/v) polyethylene glycol monoethyl ether 5000.	imidazole	273-282	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	0-5
25662616-8	2015	MUPP1-PDZ4 protein was a monomer with a molar mass of 16.4 kDa in solution and had a melting point of 60.3 C. Using the sitting-drop vapor-diffusion method, MUPP1-PDZ4 protein crystals were obtained in a solution (pH 7.0) containing 2% (v/v) polyethylene glycol 400, 0.1 M imidazole, and 24% (w/v) polyethylene glycol monoethyl ether 5000.	imidazole	273-282	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	0-10
25662616-8	2015	MUPP1-PDZ4 protein was a monomer with a molar mass of 16.4 kDa in solution and had a melting point of 60.3 C. Using the sitting-drop vapor-diffusion method, MUPP1-PDZ4 protein crystals were obtained in a solution (pH 7.0) containing 2% (v/v) polyethylene glycol 400, 0.1 M imidazole, and 24% (w/v) polyethylene glycol monoethyl ether 5000.	polyethylene glycol monoethyl ether	298-333	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	0-5
25662616-8	2015	MUPP1-PDZ4 protein was a monomer with a molar mass of 16.4 kDa in solution and had a melting point of 60.3 C. Using the sitting-drop vapor-diffusion method, MUPP1-PDZ4 protein crystals were obtained in a solution (pH 7.0) containing 2% (v/v) polyethylene glycol 400, 0.1 M imidazole, and 24% (w/v) polyethylene glycol monoethyl ether 5000.	polyethylene glycol monoethyl ether	298-333	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	0-10
24118405-0	2015	Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz"s role in ethanol withdrawal and support its role in voluntary ethanol consumption.	Ethanol	72-79	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	6-10
24118405-0	2015	Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz"s role in ethanol withdrawal and support its role in voluntary ethanol consumption.	Ethanol	72-79	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	11-16
24118405-4	2015	Additionally, ethanol consumption is reduced up to 18% (P = 0.006) in Mpdz(+/-) , providing the first evidence implicating Mpdz in ethanol self-administration.	Ethanol	14-21	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	70-74
24118405-0	2015	Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz"s role in ethanol withdrawal and support its role in voluntary ethanol consumption.	Ethanol	72-79	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	57-61
24118405-4	2015	Additionally, ethanol consumption is reduced up to 18% (P = 0.006) in Mpdz(+/-) , providing the first evidence implicating Mpdz in ethanol self-administration.	Ethanol	14-21	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	123-127
24118405-4	2015	Additionally, ethanol consumption is reduced up to 18% (P = 0.006) in Mpdz(+/-) , providing the first evidence implicating Mpdz in ethanol self-administration.	Ethanol	131-138	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	70-74
24118405-0	2015	Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz"s role in ethanol withdrawal and support its role in voluntary ethanol consumption.	Ethanol	125-132	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	6-10
24118405-4	2015	Additionally, ethanol consumption is reduced up to 18% (P = 0.006) in Mpdz(+/-) , providing the first evidence implicating Mpdz in ethanol self-administration.	Ethanol	131-138	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	123-127
24118405-0	2015	Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz"s role in ethanol withdrawal and support its role in voluntary ethanol consumption.	Ethanol	125-132	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	11-16
17690246-10	2007	Osmotic initiators of MUPP1 expression included NaCl, sucrose, mannitol, sodium acetate, and choline chloride but not urea.	Sodium Chloride	48-52	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	22-27
25109596-0	2014	Mpdz expression in the caudolateral substantia nigra pars reticulata is crucially involved in alcohol withdrawal.	Alcohols	94-101	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	0-4
25109596-2	2014	Although manipulation of the Mpdz gene by homologous recombination and bacterial artificial chromosome transgenesis has suggested that its expression affects alcohol withdrawal risk, the potential confounding effects of linked genes and developmental compensation currently limit interpretation.	Alcohols	158-165	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	29-33
25109596-3	2014	Here, using RNA interference (RNAi), we directly test the impact of Mpdz expression on alcohol withdrawal severity and provide brain regional mechanistic information.	Alcohols	87-94	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	68-72
25109596-4	2014	Lentiviral-mediated delivery of Mpdz short hairpin RNA (shRNA) to the caudolateral substantia nigra pars reticulata (clSNr) significantly reduces Mpdz expression and exacerbates alcohol withdrawal convulsions compared with control mice that delivered a scrambled shRNA.	Alcohols	178-185	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	32-36
25109596-7	2014	Our results confirm that Mpdz is a quantitative trait gene for alcohol withdrawal and demonstrate that its expression in the clSNr is crucially involved in risk for alcohol withdrawal.	Alcohols	63-70	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	25-29
25109596-7	2014	Our results confirm that Mpdz is a quantitative trait gene for alcohol withdrawal and demonstrate that its expression in the clSNr is crucially involved in risk for alcohol withdrawal.	Alcohols	165-172	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	25-29
21762291-1	2012	Model studies in mice indicate that the severity of alcohol withdrawal is associated with polymorphic variation and expression of the MPDZ gene.	Alcohols	52-59	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	134-138
20608999-3	2010	Previously, we identified a quantitative trait locus (QTL) and gene (Mpdz, which encodes the multi-PDZ domain protein) on chromosome 4 with a large effect on alcohol withdrawal in mice.	Alcohols	158-165	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	69-73
19175764-1	2009	BACKGROUND: Mpdz gene variations are known contributors of acute alcohol withdrawal severity and seizures in mice.	Alcohols	65-72	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	12-16
18262506-3	2008	We recently identified Mpdz within this chromosomal region as a gene that influences alcohol and barbiturate withdrawal convulsions.	Alcohols	85-92	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	23-27
18262506-9	2008	These data suggest that allelic variation in Mpdz, or a linked gene, influences SB242084- and baclofen-enhanced convulsions.	6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline	80-88	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	45-49
18262506-9	2008	These data suggest that allelic variation in Mpdz, or a linked gene, influences SB242084- and baclofen-enhanced convulsions.	Baclofen	94-102	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	45-49
18262506-10	2008	Our results are consistent with the hypothesis that Mpdz"s effects on CNS hyperexcitability, including alcohol and barbiturate withdrawal, involve MPDZ interaction with 5-HT2C and/or GABAB receptors.	Alcohols	103-110	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	52-56
18262506-10	2008	Our results are consistent with the hypothesis that Mpdz"s effects on CNS hyperexcitability, including alcohol and barbiturate withdrawal, involve MPDZ interaction with 5-HT2C and/or GABAB receptors.	barbituric acid	115-126	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	52-56
17690246-10	2007	Osmotic initiators of MUPP1 expression included NaCl, sucrose, mannitol, sodium acetate, and choline chloride but not urea.	Sucrose	54-61	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	22-27
17690246-10	2007	Osmotic initiators of MUPP1 expression included NaCl, sucrose, mannitol, sodium acetate, and choline chloride but not urea.	Mannitol	63-71	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	22-27
17690246-10	2007	Osmotic initiators of MUPP1 expression included NaCl, sucrose, mannitol, sodium acetate, and choline chloride but not urea.	Sodium Acetate	73-87	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	22-27
17690246-10	2007	Osmotic initiators of MUPP1 expression included NaCl, sucrose, mannitol, sodium acetate, and choline chloride but not urea.	Choline	93-109	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	22-27
14960011-4	2004	Here, we report that MPDZ status cosegregates with withdrawal convulsion severity in lines of mice selectively bred for phenotypic differences in severity of acute withdrawal from alcohol [i.e., High Alcohol Withdrawal (HAW) and Low Alcohol Withdrawal (LAW) lines] or pentobarbital [High Pentobarbital Withdrawal (HPW) and Low Pentobarbital Withdrawal (LPW) lines].	Alcohols	180-187	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	21-25
14960011-4	2004	Here, we report that MPDZ status cosegregates with withdrawal convulsion severity in lines of mice selectively bred for phenotypic differences in severity of acute withdrawal from alcohol [i.e., High Alcohol Withdrawal (HAW) and Low Alcohol Withdrawal (LAW) lines] or pentobarbital [High Pentobarbital Withdrawal (HPW) and Low Pentobarbital Withdrawal (LPW) lines].	Alcohols	200-207	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	21-25
14960011-4	2004	Here, we report that MPDZ status cosegregates with withdrawal convulsion severity in lines of mice selectively bred for phenotypic differences in severity of acute withdrawal from alcohol [i.e., High Alcohol Withdrawal (HAW) and Low Alcohol Withdrawal (LAW) lines] or pentobarbital [High Pentobarbital Withdrawal (HPW) and Low Pentobarbital Withdrawal (LPW) lines].	Pentobarbital	268-281	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	21-25
14960011-4	2004	Here, we report that MPDZ status cosegregates with withdrawal convulsion severity in lines of mice selectively bred for phenotypic differences in severity of acute withdrawal from alcohol [i.e., High Alcohol Withdrawal (HAW) and Low Alcohol Withdrawal (LAW) lines] or pentobarbital [High Pentobarbital Withdrawal (HPW) and Low Pentobarbital Withdrawal (LPW) lines].	Pentobarbital	288-301	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	21-25
14960011-4	2004	Here, we report that MPDZ status cosegregates with withdrawal convulsion severity in lines of mice selectively bred for phenotypic differences in severity of acute withdrawal from alcohol [i.e., High Alcohol Withdrawal (HAW) and Low Alcohol Withdrawal (LAW) lines] or pentobarbital [High Pentobarbital Withdrawal (HPW) and Low Pentobarbital Withdrawal (LPW) lines].	Pentobarbital	327-340	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	21-25
14960011-5	2004	These analyses confirm that MPDZ status is associated with severity of alcohol and pentobarbital withdrawal convulsions.	Alcohols	71-78	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	28-32
14960011-5	2004	These analyses confirm that MPDZ status is associated with severity of alcohol and pentobarbital withdrawal convulsions.	Pentobarbital	83-96	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	28-32
14960011-7	2004	Our results show that MPDZ status is genetically correlated with seizure sensitivity to pentylenetetrazol, kainate and other chemiconvulsants.	Pentylenetetrazole	88-105	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	22-26
14960011-7	2004	Our results show that MPDZ status is genetically correlated with seizure sensitivity to pentylenetetrazol, kainate and other chemiconvulsants.	Kainic Acid	107-114	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	22-26
12682077-3	2003	MUPP1 PDZ domain 10 (PDZ 10) associates with Ser458-Ser-Val at the carboxyl-terminal tail of the 5-HT2C R.	Valine	56-59	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	0-5
12682077-7	2003	To investigate whether phosphorylation of these serines in the receptor regulates MUPP1 interaction, we used several approaches.	Serine	48-55	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	82-87
12682077-12	2003	Alkaline phosphatase treatment reverses the effect of serotonin, indicating that agonist-induced phosphorylation at Ser458 resulted in a loss of MUPP1 association and also revealed a significant amount of basal phosphorylation of the receptor.	Serotonin	54-63	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	145-150
11978849-9	2002	These analyses, and evidence using interval-specific congenic lines, show that alcohol withdrawal severity is genetically correlated with MPDZ status, indicating that MPDZ variants may influence alcohol withdrawal liability.	Alcohols	79-86	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	138-142
11978849-9	2002	These analyses, and evidence using interval-specific congenic lines, show that alcohol withdrawal severity is genetically correlated with MPDZ status, indicating that MPDZ variants may influence alcohol withdrawal liability.	Alcohols	79-86	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	167-171
11978849-9	2002	These analyses, and evidence using interval-specific congenic lines, show that alcohol withdrawal severity is genetically correlated with MPDZ status, indicating that MPDZ variants may influence alcohol withdrawal liability.	Alcohols	195-202	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	138-142
11978849-9	2002	These analyses, and evidence using interval-specific congenic lines, show that alcohol withdrawal severity is genetically correlated with MPDZ status, indicating that MPDZ variants may influence alcohol withdrawal liability.	Alcohols	195-202	multiple PDZ domain crumbs cell polarity complex component	Mus musculus	167-171