PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
25971952-3	2015	Here, we review the most recent findings in human and mouse studies on PDE8B, a cAMP-specific PDE that appears to be highly expressed in the adrenal cortex and whose deficiency may underlie predisposition to BAH and possibly other human diseases.	Cyclic AMP	80-84	phosphodiesterase 8B	Mus musculus	71-76
26643407-4	2016	We have recently shown that PDE4B and PDE4C as well as PDE8A and PDE8B are expressed in rodent Leydig cells and that combined inhibition of PDE4 and PDE8 leads to dramatically increased steroid biosynthesis.	Steroids	186-193	phosphodiesterase 8B	Mus musculus	65-70
25971952-3	2015	Here, we review the most recent findings in human and mouse studies on PDE8B, a cAMP-specific PDE that appears to be highly expressed in the adrenal cortex and whose deficiency may underlie predisposition to BAH and possibly other human diseases.	bis(5-amidino-2-benzimidazolyl)methane ketone hydrate	208-211	phosphodiesterase 8B	Mus musculus	71-76
22232524-1	2012	Phosphodiesterase (PDE) 8A and PDE8B are high-affinity, cAMP-specific phosphodiesterases that are highly expressed in Leydig cells.	Cyclic AMP	56-60	phosphodiesterase 8B	Mus musculus	31-36
22946044-9	2012	Knockdown of the IBMX-insensitive PDE8B by shRNA in MIN6 cells increased the basal level of [cAMP](pm) and prevented the [cAMP](pm)-lowering effect of 2",5"-dideoxyadenosine after exposure to IBMX.	2',5'-dideoxyadenosine	151-173	phosphodiesterase 8B	Mus musculus	34-39
22946044-10	2012	Moreover, PDE8B-knockdown cells showed reduced glucose-induced [cAMP](pm) oscillations and loss of the normal pulsatile pattern of insulin secretion.	Glucose	47-54	phosphodiesterase 8B	Mus musculus	10-15
22232524-11	2012	Together these findings suggest that both PDE8A and PDE8B play essential roles to maintain low cAMP levels, thereby suppressing resting steroidogenesis by keeping CEH/HSL inactive and StAR protein expression low.	Cyclic AMP	95-99	phosphodiesterase 8B	Mus musculus	52-57
34875337-4	2022	We have investigated whether three PDE5i, sildenafil, tadalafil and vardenafil, cross-interacts with the high affinity cAMP-specific enzymes type 8A and 8B PDEs (PDE8A and PDE8B), in live, transfected mouse Leydig tumor (mLTC1) and human embryonic kidney (HEK293) cell lines in vitro.	Cyclic AMP	119-123	phosphodiesterase 8B	Mus musculus	172-177
21187369-0	2011	The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland.	Cyclic AMP	18-22	phosphodiesterase 8B	Mus musculus	32-52
21187369-3	2011	We demonstrate that PDE8B is highly enriched in mouse adrenal fasciculata cells, and show that PDE8B knockout mice have elevated urinary corticosterone as a result of adrenal hypersensitivity toward adrenocorticotropin.	Corticosterone	137-151	phosphodiesterase 8B	Mus musculus	20-25
21187369-3	2011	We demonstrate that PDE8B is highly enriched in mouse adrenal fasciculata cells, and show that PDE8B knockout mice have elevated urinary corticosterone as a result of adrenal hypersensitivity toward adrenocorticotropin.	Corticosterone	137-151	phosphodiesterase 8B	Mus musculus	95-100
21187369-5	2011	We also observed that the PDE8-selective inhibitor (PF-04957325) potentiates adrenocorticotropin stimulation of steroidogenesis by increasing cAMP-dependent protein kinase activity in both primary isolated adrenocortical cells and Y-1 cells.	PF-04957325	52-63	phosphodiesterase 8B	Mus musculus	26-30
21187369-8	2011	We conclude that PDE8B is a major regulator of one or more pools of cAMP that promote steroidogenesis via both short- and long-term mechanisms.	Cyclic AMP	68-72	phosphodiesterase 8B	Mus musculus	17-22
18431404-0	2008	A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex.	Cyclic AMP	2-6	phosphodiesterase 8B	Mus musculus	137-142