PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
12842914-7	2003	Furthermore, PKC delta formed a complex with Dishevelled, and the activation of PKC delta by phorbol ester was sufficient for Dishevelled translocation and JNK activation.	Phorbol Esters	93-106	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	156-159
20585507-10	2010	By single cell analysis we found that the response of AMPK and JNK to hyperosmolar sorbitol is all-or-none (digital) in character, and that initial graded responses of both protein kinases are converted into digital during the critical period of cytochrome c release.	Sorbitol	83-91	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	63-66
11516948-3	2001	We experimentally assessed the response of JNK to a physiological stimulus (progesterone) and a pathological stress (hyperosmolar sorbitol) in Xenopus laevis oocytes, a cell type that is well-suited to the quantitative analysis of cell signaling.	Progesterone	76-88	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	43-46
11516948-3	2001	We experimentally assessed the response of JNK to a physiological stimulus (progesterone) and a pathological stress (hyperosmolar sorbitol) in Xenopus laevis oocytes, a cell type that is well-suited to the quantitative analysis of cell signaling.	Sorbitol	130-138	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	43-46
11516948-5	2001	RESULTS: The responses of JNK to both progesterone and sorbitol were found to be essentially all-or-none.	Progesterone	38-50	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	26-29
11516948-5	2001	RESULTS: The responses of JNK to both progesterone and sorbitol were found to be essentially all-or-none.	Sorbitol	55-63	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	26-29
11516948-8	2001	JNK also exhibited hysteresis, a form of biochemical memory, in its response to sorbitol.	Sorbitol	80-88	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	0-3
26459765-0	2015	Perfluoroheptanoic acid affects amphibian embryogenesis by inducing the phosphorylation of ERK and JNK.	pfhpa	0-23	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	99-102
26459765-7	2015	In addition, immunoblotting revealed that PFHpA significantly increased the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), while PFHxA slightly increased these, as compared with the control.	pfhpa	42-47	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	143-166
26459765-7	2015	In addition, immunoblotting revealed that PFHpA significantly increased the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), while PFHxA slightly increased these, as compared with the control.	pfhpa	42-47	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	168-171
26459765-8	2015	These results suggest that PFHxA and PFHpA are developmental toxicants and teratogens, with PFHpA producing more severe effects on liver and heart development through the induction of ERK and JNK phosphorylation.	perfluorohexanoic acid	27-32	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	192-195
26459765-8	2015	These results suggest that PFHxA and PFHpA are developmental toxicants and teratogens, with PFHpA producing more severe effects on liver and heart development through the induction of ERK and JNK phosphorylation.	pfhpa	37-42	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	192-195
26459765-8	2015	These results suggest that PFHxA and PFHpA are developmental toxicants and teratogens, with PFHpA producing more severe effects on liver and heart development through the induction of ERK and JNK phosphorylation.	pfhpa	92-97	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	192-195
11970895-0	2002	Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation.	dapper	0-6	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	64-67
11970895-4	2002	Dapper also inhibits activation by Dishevelled of c-Jun N-terminal kinase (JNK), a component of beta-catenin-independent Frizzled signaling.	dapper	0-6	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	50-73
11970895-4	2002	Dapper also inhibits activation by Dishevelled of c-Jun N-terminal kinase (JNK), a component of beta-catenin-independent Frizzled signaling.	dapper	0-6	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	75-78
11029471-9	2001	Thus, progesterone can stimulate JNK activation both through the MEK/p42 MAPK pathway and through MEK/p42 MAPK-independent pathways.	Progesterone	6-18	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	33-36
26270962-0	2015	Xenopus Pkdcc1 and Pkdcc2 Are Two New Tyrosine Kinases Involved in the Regulation of JNK Dependent Wnt/PCP Signaling Pathway.	pcp	103-106	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	85-88
24780839-8	2014	In conclusion, PMA exerted its anti-cancer effects via the activation of pro-apoptotic JNK/p53 and inhibition of pro-proliferative E2F1/AR in prostate cancer cells including CRPC cells.	Tetradecanoylphorbol Acetate	15-18	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	87-90
17060633-4	2006	Although JNK activity is not required for the glycogen synthase kinase-3-mediated degradation of beta-catenin, inhibition of the maternal JNK signaling by morpholino-antisense oligos causes hyperdorsalization of Xenopus embryos and ectopic expression of the Wnt/beta-catenin target genes.	Morpholinos	155-165	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	138-141
14751548-2	2004	We examined the role of Mos, Mek, PI-3 kinase and c-Jun N-terminal kinase (JNK) in progesterone stimulation of GVBD.	Progesterone	83-95	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	75-78
16331688-4	2006	We show that cell-cycle progression and activation of MAPK and JNK mediated by the oncogenic Met receptor, Tpr-Met, are dependent on its kinase activity and the presence of the twin phosphotyrosine (Y482 & Y489) residues in its C-terminus, but that the recruitment of Grb2 and Shc adaptor proteins is dispensable, implicating other signaling molecules.	Phosphotyrosine	182-197	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	63-66
16331688-4	2006	We show that cell-cycle progression and activation of MAPK and JNK mediated by the oncogenic Met receptor, Tpr-Met, are dependent on its kinase activity and the presence of the twin phosphotyrosine (Y482 & Y489) residues in its C-terminus, but that the recruitment of Grb2 and Shc adaptor proteins is dispensable, implicating other signaling molecules.	Adenosine Monophosphate	205-208	mitogen-activated protein kinase 8 L homeolog	Xenopus laevis	63-66