PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
291922-5	1979	Finally, the compactin-induced inhibition of DNA synthesis could be completely reversed within minutes by the addition of mevalonate, the product of the HMG CoA reductase reaction.	Mevalonic Acid	122-132	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	153-170
2471016-6	1989	Hepatic cholesterol synthesis, measured as acetate incorporation into cholesterol and hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase activity, was also lowered in the doxazosin-treated hamsters.	Doxazosin	173-182	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	86-138
291922-7	1979	These data demonstrate that HMG CoA reductase activity, and therefore the production of mevalonate, plays an essential role in the synthesis of DNA specifically during the S phase of the cell cycle.	Mevalonic Acid	88-98	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	28-45
25701719-4	2015	In animals that are sensitive to dietary cholesterol such as Golden Syrian hamsters, feedback regulation occurs mainly at the level of transcription of hepatic HMG-CoA reductase (3-hydroxy-3-methylglutaryl coenzyme A reductase).	Cholesterol	41-52	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	160-177
26593426-4	2016	Furthermore, the antidyslipidemia effect of epiberberine on key genes involved in cholesterol biosynthesis, uptake, conversion and elimination such as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), low density lipoprotein receptor (LDL receptor), 7-alpha-hydroxylase (CYP7A1) and apical sodium dependent bile acid transporter (ASBT) were investigated.	epiberberine	44-56	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	151-191
26593426-4	2016	Furthermore, the antidyslipidemia effect of epiberberine on key genes involved in cholesterol biosynthesis, uptake, conversion and elimination such as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), low density lipoprotein receptor (LDL receptor), 7-alpha-hydroxylase (CYP7A1) and apical sodium dependent bile acid transporter (ASBT) were investigated.	epiberberine	44-56	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	193-198
26593426-6	2016	Epiberberine inhibited HMGCR mRNA and protein expressions and slightly reduced the protein level of ASBT, as well as dramatically up-regulated mRNA and protein expressions of CYP7A1 and LDL receptor.	epiberberine	0-12	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	23-28
25701719-4	2015	In animals that are sensitive to dietary cholesterol such as Golden Syrian hamsters, feedback regulation occurs mainly at the level of transcription of hepatic HMG-CoA reductase (3-hydroxy-3-methylglutaryl coenzyme A reductase).	Cholesterol	41-52	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	179-226
25547428-5	2015	Further investigation has suggested that the mRNA and protein expression of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) in the liver of hamsters was down-regulated by high-dosage coptisine treatment (p < 0.05); mRNA and protein expression of low-density lipoprotein receptor (LDLR) and cholesterol 7alpha-hydroxylase (CYP7A1) were dramatically up-regulated by coptisine administration.	coptisine	185-194	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	76-117
25547428-5	2015	Further investigation has suggested that the mRNA and protein expression of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) in the liver of hamsters was down-regulated by high-dosage coptisine treatment (p < 0.05); mRNA and protein expression of low-density lipoprotein receptor (LDLR) and cholesterol 7alpha-hydroxylase (CYP7A1) were dramatically up-regulated by coptisine administration.	coptisine	185-194	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	119-124
25547428-5	2015	Further investigation has suggested that the mRNA and protein expression of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) in the liver of hamsters was down-regulated by high-dosage coptisine treatment (p < 0.05); mRNA and protein expression of low-density lipoprotein receptor (LDLR) and cholesterol 7alpha-hydroxylase (CYP7A1) were dramatically up-regulated by coptisine administration.	coptisine	369-378	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	76-117
25547428-5	2015	Further investigation has suggested that the mRNA and protein expression of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR) in the liver of hamsters was down-regulated by high-dosage coptisine treatment (p < 0.05); mRNA and protein expression of low-density lipoprotein receptor (LDLR) and cholesterol 7alpha-hydroxylase (CYP7A1) were dramatically up-regulated by coptisine administration.	coptisine	369-378	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	119-124
25547428-7	2015	Taken together, our results demonstrate that a high dosage of coptisine could inhibit cholesterol synthesis via suppressing the HMGCR expression and promoting the use and excretion of cholesterol via up-regulating LDLR and CYP7A1 expression.	coptisine	62-71	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	128-133
21394808-1	2011	Currently used hypolipidemic drugs, Fluvastatin and Atorvastatin, act via inhibiting the rate-limiting enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase of the mevalonate pathway.	Fluvastatin	36-47	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	110-168
25218494-6	2015	However, supplementation with GOH counteracted the hyperlipidemia by inhibiting HMG CoA reductase and suppressing lipogenesis.	5-[2-Cyclopropyl-5-(1h-Pyrrol-1-Yl)-1,3-Oxazol-4-Yl]-1h-1,2,3,4-Tetrazole	30-33	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	80-97
21394808-1	2011	Currently used hypolipidemic drugs, Fluvastatin and Atorvastatin, act via inhibiting the rate-limiting enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase of the mevalonate pathway.	Atorvastatin	52-64	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	110-168
21394808-1	2011	Currently used hypolipidemic drugs, Fluvastatin and Atorvastatin, act via inhibiting the rate-limiting enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase of the mevalonate pathway.	Mevalonic Acid	176-186	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	110-168
18166149-0	2008	Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters.	Resveratrol	0-11	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	41-58
21470496-0	2011	Glycyrrhizic acid attenuates the expression of HMG-CoA reductase mRNA in high fructose diet induced dyslipidemic hamsters.	Glycyrrhizic Acid	0-17	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	47-64
21470496-0	2011	Glycyrrhizic acid attenuates the expression of HMG-CoA reductase mRNA in high fructose diet induced dyslipidemic hamsters.	Fructose	78-86	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	47-64
21470496-1	2011	We investigated the hypolipidemic effect of glycyrrhizic acid (GA) focused on the mRNA expression and hepatic HMG-CoA reductase (HMGR) activity in hamsters fed a high-fat diet.	Glycyrrhizic Acid	44-61	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	110-127
21470496-7	2011	These results indicate that GA treatment reduces plasma cholesterol by down-regulating hepatic HMGR mRNA expression in hamsters fed a high fructose-fat diet.	Fructose	139-147	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	95-99
18166149-6	2008	Real-time PCR analysis revealed that HMGR mRNA expression was significantly lower in the resveratrol group than in the control group.	Resveratrol	89-100	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	37-41
18166149-7	2008	These results indicate that dietary resveratrol reduces serum cholesterol by down-regulating hepatic HMGR mRNA expression in hamsters fed a high-fat diet.	Resveratrol	36-47	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	101-105
15170109-6	2004	Fractions showing relatively high HMG-CoA reductase inhibition were further purified through Sephadex LH-20 column chromatography and C18 preparative HPLC, and the inhibitory compounds were identified as genistein, daidzein, and glycitein.	Genistein	204-213	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	34-51
8835365-1	1995	The present study analyses the effects of simvastatin, a specific inhibitor of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA reductase) in male Syrian hamsters fed a standard diet or a diet supplemented with 0.12% cholesterol and 20% coconut oil.	Simvastatin	42-53	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	122-139
11912545-2	2002	Here, we investigated whether hepatic lipoprotein overproduction can be ameliorated by treatment with a hydroxymethyl glutaryl conenzyme A (HMG-CoA) reductase inhibitor, atorvastatin, using a series of ex vivo experiments.	Atorvastatin	170-182	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	104-158
10405006-9	1999	The activities of hepatic HMGCoA reductase, the rate-limiting enzyme for cholesterol synthesis, increased (+125%, p=0.06); hepatic cholesterol 7alpha-hydroxylase, the rate-limiting enzyme for bile acid synthesis, decreased (-85%); and the hepatic LDL receptor mass also decreased (-44%).	Cholesterol	73-84	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	26-42
9763219-0	1998	Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4"-(6-allyl-ethyl-amino-hexyloxy)-2"-fluoro-phenyl]-(4-bromophenyl)-me thanone (Ro 48-8071): comparison to simvastatin.	Ro 48-8071	242-252	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	19-66
9763219-0	1998	Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4"-(6-allyl-ethyl-amino-hexyloxy)-2"-fluoro-phenyl]-(4-bromophenyl)-me thanone (Ro 48-8071): comparison to simvastatin.	Simvastatin	269-280	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	19-66
9763219-3	1998	This trait is attributed to increased levels of oxysterols, produced upon partial inhibition of OSC, that suppress HMGR and other sterol-responsive genes.	Oxysterols	48-58	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	115-119
9763219-4	1998	The OSC inhibitor [4"-(6-allyl-ethyl-amino-hexyloxy)-2"-fluoro-phenyl]-(4-bromopheny l)-methanone (Ro 48-8071) was shown earlier to lower low-density lipoprotein (LDL) cholesterol in hamsters with no increase in hepatic HMGR, in contrast to simvastatin.	Ro 48-8071	99-109	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	220-224
9763219-6	1998	Using RNase protection and radioimmunoprecipitation assays, we found that, in the absence of LDL in the culture medium, both HMGR mRNA levels and synthesis were reduced with concentrations of Ro 48-8071 inhibiting cholesterol synthesis by 50-75%, whereas LDL uptake was either reduced or unchanged.	ro 48	192-197	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	125-129
9763219-6	1998	Using RNase protection and radioimmunoprecipitation assays, we found that, in the absence of LDL in the culture medium, both HMGR mRNA levels and synthesis were reduced with concentrations of Ro 48-8071 inhibiting cholesterol synthesis by 50-75%, whereas LDL uptake was either reduced or unchanged.	Cholesterol	214-225	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	125-129
9763219-7	1998	In contrast, simvastatin, at concentrations inhibiting cholesterol synthesis by the same 50-75%, increased both HMGR mRNA levels and synthesis, as well as LDL uptake.	Simvastatin	13-24	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	112-116
9763219-7	1998	In contrast, simvastatin, at concentrations inhibiting cholesterol synthesis by the same 50-75%, increased both HMGR mRNA levels and synthesis, as well as LDL uptake.	Cholesterol	55-66	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	112-116
9763219-9	1998	Still, simvastatin markedly increased both HMGR mRNA levels and synthesis in cells incubated in the presence of LDL, leaving LDL uptake unaffected.	Simvastatin	7-18	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	43-47
9016820-0	1997	Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level.	Mevalonic Acid	66-76	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	101-148
8835365-5	1995	All elevated biochemical changes and morphological alterations were prevented or reversed by coadministration of mevalonate, the product of the HMG-CoA reductase.	Mevalonic Acid	113-123	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	144-161
8835365-7	1995	The toxicity of simvastatin could indeed result from the low basal activity of HMG-CoA reductase in hamster liver coupled with a prolonged inhibition of mevalonate synthesis.	Simvastatin	16-27	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	79-96
7605373-1	1995	3-Hydroxy-3-methylglutaryl-CoA (HMG CoA) reductase inhibitors are the drugs most commonly prescribed in the US to lower blood cholesterol.	Cholesterol	126-137	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	0-50
1720835-10	1991	When determined under optimal conditions, i.e., after prior dephosphorylation, the hepatic microsomal HMG-CoA reductase activity was lowered by 10-25% in the doxazosin-treated animals.	Doxazosin	158-167	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	102-119
1720835-11	1991	However, if HMG-CoA reductase was determined under conditions to prevent phosphorylation and dephosphorylation of the enzyme, representing the in situ expressed activity, the activity in the doxazosin-treated animals was 40% lower than in the controls.	Doxazosin	191-200	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	12-29
1720835-12	1991	These results indicate that the plasma lipid-lowering effect of doxazosin is largely due to its interference with hepatic lipid metabolism and that one of the effects is a lowering of hepatic cholesterol synthesis, probably due to an increase in the phosphorylation grade of HMG-CoA reductase.	Doxazosin	64-73	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	275-292
8301233-14	1993	It is possible that increases in hepatic HMG-CoA reductase provide cholesterol that allows for the increased production of lipoproteins and elevations in serum lipid levels that may be beneficial to the body"s host defense.	Cholesterol	67-78	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	41-58
8424783-3	1993	We have examined protein isoprenylation, subcellular distribution of SMGs, cytosolic Ca2+ changes and insulin secretion in HIT-T15 cells after treatment with lovastatin, which inhibits the production of isoprenoids by blocking mevalonate production by 3-hydroxy-3-methylglutaryl-CoA reductase.	Lovastatin	158-168	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	252-292
1546367-0	1992	Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis in Syrian hamster C100 cells by mevinolin, 25-hydroxycholesterol, and mevalonate: the role of posttranscriptional control.	Lovastatin	104-113	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	14-61
1546367-0	1992	Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis in Syrian hamster C100 cells by mevinolin, 25-hydroxycholesterol, and mevalonate: the role of posttranscriptional control.	25-hydroxycholesterol	115-136	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	14-61
1546367-0	1992	Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis in Syrian hamster C100 cells by mevinolin, 25-hydroxycholesterol, and mevalonate: the role of posttranscriptional control.	Mevalonic Acid	142-152	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	14-61
1546367-2	1992	In this study the effects of the oxysterol 25-hydroxycholesterol and mevalonate on the mRNA level and rate of synthesis for HMG-CoA reductase were evaluated in C100 cells treated with mevinolin, a competitive inhibitor of HMG-CoA reductase.	oxysterol 25-hydroxycholesterol	33-64	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	124-141
1546367-2	1992	In this study the effects of the oxysterol 25-hydroxycholesterol and mevalonate on the mRNA level and rate of synthesis for HMG-CoA reductase were evaluated in C100 cells treated with mevinolin, a competitive inhibitor of HMG-CoA reductase.	Mevalonic Acid	69-79	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	124-141
1546367-2	1992	In this study the effects of the oxysterol 25-hydroxycholesterol and mevalonate on the mRNA level and rate of synthesis for HMG-CoA reductase were evaluated in C100 cells treated with mevinolin, a competitive inhibitor of HMG-CoA reductase.	Lovastatin	184-193	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	124-141
1546367-2	1992	In this study the effects of the oxysterol 25-hydroxycholesterol and mevalonate on the mRNA level and rate of synthesis for HMG-CoA reductase were evaluated in C100 cells treated with mevinolin, a competitive inhibitor of HMG-CoA reductase.	Lovastatin	184-193	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	222-239
1546367-3	1992	The addition of 25-hydroxycholesterol to the cell culture medium resulted in a fourfold decrease in both the rate of synthesis and mRNA level for HMG-CoA reductase.	25-hydroxycholesterol	16-37	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	146-163
1546367-6	1992	Degradation of HMG-CoA reductase was rapid in the presence (t1/2 = 1.34 h) or absence (t1/2 = 1.17 h) of mevinolin and was not changed significantly by adding either 25-hydroxycholesterol, alone (t1/2 = 1.30 h) or both 25-hydroxycholesterol and mevalonate (t1/2 = 1.30 h) to mevinolin-treated cells.	Lovastatin	105-114	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	15-32
1546367-6	1992	Degradation of HMG-CoA reductase was rapid in the presence (t1/2 = 1.34 h) or absence (t1/2 = 1.17 h) of mevinolin and was not changed significantly by adding either 25-hydroxycholesterol, alone (t1/2 = 1.30 h) or both 25-hydroxycholesterol and mevalonate (t1/2 = 1.30 h) to mevinolin-treated cells.	25-hydroxycholesterol	166-187	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	15-32
1546367-6	1992	Degradation of HMG-CoA reductase was rapid in the presence (t1/2 = 1.34 h) or absence (t1/2 = 1.17 h) of mevinolin and was not changed significantly by adding either 25-hydroxycholesterol, alone (t1/2 = 1.30 h) or both 25-hydroxycholesterol and mevalonate (t1/2 = 1.30 h) to mevinolin-treated cells.	25-hydroxycholesterol	219-240	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	15-32
1546367-6	1992	Degradation of HMG-CoA reductase was rapid in the presence (t1/2 = 1.34 h) or absence (t1/2 = 1.17 h) of mevinolin and was not changed significantly by adding either 25-hydroxycholesterol, alone (t1/2 = 1.30 h) or both 25-hydroxycholesterol and mevalonate (t1/2 = 1.30 h) to mevinolin-treated cells.	Mevalonic Acid	245-255	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	15-32
1546367-6	1992	Degradation of HMG-CoA reductase was rapid in the presence (t1/2 = 1.34 h) or absence (t1/2 = 1.17 h) of mevinolin and was not changed significantly by adding either 25-hydroxycholesterol, alone (t1/2 = 1.30 h) or both 25-hydroxycholesterol and mevalonate (t1/2 = 1.30 h) to mevinolin-treated cells.	Lovastatin	275-284	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	15-32
1546367-7	1992	This study demonstrates that mevalonate and 25-hydroxycholesterol act synergistically in the presence of mevinolin to achieve a greater degree of suppression in the rate of HMG-CoA reductase synthesis than can be accounted for by their individual effects on HMG-CoA reductase mRNA.	Mevalonic Acid	29-39	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	173-190
1546367-7	1992	This study demonstrates that mevalonate and 25-hydroxycholesterol act synergistically in the presence of mevinolin to achieve a greater degree of suppression in the rate of HMG-CoA reductase synthesis than can be accounted for by their individual effects on HMG-CoA reductase mRNA.	Mevalonic Acid	29-39	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	258-275
1546367-7	1992	This study demonstrates that mevalonate and 25-hydroxycholesterol act synergistically in the presence of mevinolin to achieve a greater degree of suppression in the rate of HMG-CoA reductase synthesis than can be accounted for by their individual effects on HMG-CoA reductase mRNA.	25-hydroxycholesterol	44-65	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	173-190
1546367-7	1992	This study demonstrates that mevalonate and 25-hydroxycholesterol act synergistically in the presence of mevinolin to achieve a greater degree of suppression in the rate of HMG-CoA reductase synthesis than can be accounted for by their individual effects on HMG-CoA reductase mRNA.	25-hydroxycholesterol	44-65	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	258-275
1546367-7	1992	This study demonstrates that mevalonate and 25-hydroxycholesterol act synergistically in the presence of mevinolin to achieve a greater degree of suppression in the rate of HMG-CoA reductase synthesis than can be accounted for by their individual effects on HMG-CoA reductase mRNA.	Lovastatin	105-114	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	173-190
1546367-7	1992	This study demonstrates that mevalonate and 25-hydroxycholesterol act synergistically in the presence of mevinolin to achieve a greater degree of suppression in the rate of HMG-CoA reductase synthesis than can be accounted for by their individual effects on HMG-CoA reductase mRNA.	Lovastatin	105-114	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	258-275
1546367-8	1992	In addition, the data suggest that mevalonate affects the synthesis of HMG-CoA reductase at a yet unidentified posttranscriptional control site.	Mevalonic Acid	35-45	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	71-88
35470867-4	2022	Moreover, sinapic acid intervention increased the activations of PPAR-gamma, CPT-1, and CYP7A1 and decreased the activations of FAS, ACC1, SREBP1, SREBP2, and HMGCR in the livers of HFD hamsters.	sinapinic acid	10-22	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	159-164