PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 3998120-1 1985 In an examination of arginine-utilizing Mycoplasma species, simple fluorogenic and chromogenic tests were used to demonstrate high levels of arginine aminopeptidase activity in unwashed, unconcentrated broth and agar cultures in all strains of 5 species and low levels of activity in all strains of 14 species. Arginine 21-29 arginyl aminopeptidase Homo sapiens 141-164 6429060-1 1984 Bestatin is an inhibitor of leucine aminopeptidase and aminopeptidase B which potentiates various immune functions, such as delayed hypersensitivity and antibody formation, and inhibits tumor cell growth in animal models. ubenimex 0-8 arginyl aminopeptidase Homo sapiens 55-71 6714935-11 1984 Aminopeptidase 5 exhibited the properties alike aminopeptidase B with high specific hydrolytic activity against the 4-nitroanilides of lysine and arginine. 4-nitroanilides 116-131 arginyl aminopeptidase Homo sapiens 48-64 6714935-11 1984 Aminopeptidase 5 exhibited the properties alike aminopeptidase B with high specific hydrolytic activity against the 4-nitroanilides of lysine and arginine. Lysine 135-141 arginyl aminopeptidase Homo sapiens 48-64 6714935-11 1984 Aminopeptidase 5 exhibited the properties alike aminopeptidase B with high specific hydrolytic activity against the 4-nitroanilides of lysine and arginine. Arginine 146-154 arginyl aminopeptidase Homo sapiens 48-64 6526742-0 1984 Structure-activity relationships among derivatives of arphamenines, inhibitors of aminopeptidase B. arphamenines 54-66 arginyl aminopeptidase Homo sapiens 82-98 6142930-3 1984 Responses to iontophoretically applied L-glutamate desensitize rapidly and are antagonized by 2-amino-4-phosphonobutyric acid (2-APB). Glutamic Acid 39-50 arginyl aminopeptidase Homo sapiens 129-132 6142930-3 1984 Responses to iontophoretically applied L-glutamate desensitize rapidly and are antagonized by 2-amino-4-phosphonobutyric acid (2-APB). 2-amino-4-phosphonobutyric acid 94-125 arginyl aminopeptidase Homo sapiens 129-132 7056602-2 1982 By means of this method, several small molecular weight compounds, bestatin, amastatin, forphenicine, and esterastin, inhibiting enzymes located on the cell surface, aminopeptidase B and leucine aminopeptidase, aminopeptidase A, alkaline phosphatase, and esterase, were discovered. ubenimex 67-75 arginyl aminopeptidase Homo sapiens 166-182 6654760-0 1983 Arphamenines A and B, new inhibitors of aminopeptidase B, produced by bacteria. arphamenines a and b 0-20 arginyl aminopeptidase Homo sapiens 40-56 7056602-2 1982 By means of this method, several small molecular weight compounds, bestatin, amastatin, forphenicine, and esterastin, inhibiting enzymes located on the cell surface, aminopeptidase B and leucine aminopeptidase, aminopeptidase A, alkaline phosphatase, and esterase, were discovered. amastatin 77-86 arginyl aminopeptidase Homo sapiens 166-182 7056602-2 1982 By means of this method, several small molecular weight compounds, bestatin, amastatin, forphenicine, and esterastin, inhibiting enzymes located on the cell surface, aminopeptidase B and leucine aminopeptidase, aminopeptidase A, alkaline phosphatase, and esterase, were discovered. forphenicine 88-100 arginyl aminopeptidase Homo sapiens 166-182 7056602-2 1982 By means of this method, several small molecular weight compounds, bestatin, amastatin, forphenicine, and esterastin, inhibiting enzymes located on the cell surface, aminopeptidase B and leucine aminopeptidase, aminopeptidase A, alkaline phosphatase, and esterase, were discovered. esterastin 106-116 arginyl aminopeptidase Homo sapiens 166-182 7251498-0 1980 Isolation of alpha-aminoacyl arginines in screening of aminopeptidase B inhibitors. alpha-aminoacyl arginines 13-38 arginyl aminopeptidase Homo sapiens 55-71 6161918-2 1980 Porcine liver aminopeptidase B[EC 3.4.11.6] is highly specific for hydrolysis of beta-naphthylamides of basic L-amino acids; the Km values for L-arginine beta-naphthylamide and L-lysine beta-naphthylamide were 0.035 and 0.12 mM, respectively. 2-naphthylamide 81-100 arginyl aminopeptidase Homo sapiens 14-30 6161918-2 1980 Porcine liver aminopeptidase B[EC 3.4.11.6] is highly specific for hydrolysis of beta-naphthylamides of basic L-amino acids; the Km values for L-arginine beta-naphthylamide and L-lysine beta-naphthylamide were 0.035 and 0.12 mM, respectively. basic l-amino acids 104-123 arginyl aminopeptidase Homo sapiens 14-30 990309-7 1976 When bestatin, a specific inhibitor against aminopeptidase B and leucine aminopeptidase, was included in the assay system for the enzyme activities on the cell surface, the enzymes were commonly inhibited in all types of cells. ubenimex 5-13 arginyl aminopeptidase Homo sapiens 44-60 6161918-2 1980 Porcine liver aminopeptidase B[EC 3.4.11.6] is highly specific for hydrolysis of beta-naphthylamides of basic L-amino acids; the Km values for L-arginine beta-naphthylamide and L-lysine beta-naphthylamide were 0.035 and 0.12 mM, respectively. arginine beta-naphthylamide 143-172 arginyl aminopeptidase Homo sapiens 14-30 6161918-2 1980 Porcine liver aminopeptidase B[EC 3.4.11.6] is highly specific for hydrolysis of beta-naphthylamides of basic L-amino acids; the Km values for L-arginine beta-naphthylamide and L-lysine beta-naphthylamide were 0.035 and 0.12 mM, respectively. lysine-2-naphthylamide 177-204 arginyl aminopeptidase Homo sapiens 14-30 7451402-1 1980 An aminopeptidase B from porcine liver was purified about 2,000-fold by ammonium sulfate fractionation and a series of chromatographies on hydroxyapatite, DEAE-cellulose, Sephadex G-150, hydroxyapatite and DEAE-Sepharose columns. Ammonium Sulfate 72-88 arginyl aminopeptidase Homo sapiens 3-19 7451402-1 1980 An aminopeptidase B from porcine liver was purified about 2,000-fold by ammonium sulfate fractionation and a series of chromatographies on hydroxyapatite, DEAE-cellulose, Sephadex G-150, hydroxyapatite and DEAE-Sepharose columns. Durapatite 139-153 arginyl aminopeptidase Homo sapiens 3-19 7451402-1 1980 An aminopeptidase B from porcine liver was purified about 2,000-fold by ammonium sulfate fractionation and a series of chromatographies on hydroxyapatite, DEAE-cellulose, Sephadex G-150, hydroxyapatite and DEAE-Sepharose columns. DEAE-Cellulose 155-169 arginyl aminopeptidase Homo sapiens 3-19 7451402-1 1980 An aminopeptidase B from porcine liver was purified about 2,000-fold by ammonium sulfate fractionation and a series of chromatographies on hydroxyapatite, DEAE-cellulose, Sephadex G-150, hydroxyapatite and DEAE-Sepharose columns. Durapatite 187-201 arginyl aminopeptidase Homo sapiens 3-19 7451402-1 1980 An aminopeptidase B from porcine liver was purified about 2,000-fold by ammonium sulfate fractionation and a series of chromatographies on hydroxyapatite, DEAE-cellulose, Sephadex G-150, hydroxyapatite and DEAE-Sepharose columns. deae-sepharose 206-220 arginyl aminopeptidase Homo sapiens 3-19 850237-0 1977 Synthesis and structure-activity relationships of bestatin analogues, inhibitors of aminopeptidase B. ubenimex 50-58 arginyl aminopeptidase Homo sapiens 84-100 850237-1 1977 Stereoisomers and analogues of bestatin, [(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine, were synthesized and tested for aminopeptidase B and leucine aminopeptidase inhibiting activity. ubenimex 31-39 arginyl aminopeptidase Homo sapiens 129-145 931798-0 1976 Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. ubenimex 0-8 arginyl aminopeptidase Homo sapiens 26-42 993125-0 1976 Enhancement of delayed-type hypersensitivity by bestatin, an inhibitor of aminopeptidase B and leucine aminopeptidase. ubenimex 48-56 arginyl aminopeptidase Homo sapiens 74-90 4946182-0 1971 Aminopeptidase B in human gingival exudate as affected by reduced oral hygiene and sugar diet. Sugars 83-88 arginyl aminopeptidase Homo sapiens 0-16 5957133-0 1966 Purification of a mammalian peptidase selective for N-terminal arginine and lysine residues: aminopeptidase B. Arginine 63-71 arginyl aminopeptidase Homo sapiens 93-109 5957133-0 1966 Purification of a mammalian peptidase selective for N-terminal arginine and lysine residues: aminopeptidase B. Lysine 76-82 arginyl aminopeptidase Homo sapiens 93-109 32439717-0 2020 Detection and quantification of glycosylated queuosine modified tRNAs by acid denaturing and APB gels. Nucleoside Q 45-54 arginyl aminopeptidase Homo sapiens 93-96 32774412-7 2020 It has been identified that Wenxin granules combined with propafenone have better clinical efficacy than the use of propafenone alone in the treatment of APB (OR = 3.89, 95% CI (2.03, 7.44), P < 0.0001, low-dose propafenone; OR = 4.24, 95% CI (1.32, 13.60), P = 0.02, high-dose propafenone). Propafenone 116-127 arginyl aminopeptidase Homo sapiens 154-157 32774412-2 2020 Methods: A randomized controlled trial (RCT) of Wenxin granules and propafenone in the therapy of APB was systematically searched until June 1, 2019. Propafenone 68-79 arginyl aminopeptidase Homo sapiens 98-101 32774412-7 2020 It has been identified that Wenxin granules combined with propafenone have better clinical efficacy than the use of propafenone alone in the treatment of APB (OR = 3.89, 95% CI (2.03, 7.44), P < 0.0001, low-dose propafenone; OR = 4.24, 95% CI (1.32, 13.60), P = 0.02, high-dose propafenone). Propafenone 116-127 arginyl aminopeptidase Homo sapiens 154-157 32774412-7 2020 It has been identified that Wenxin granules combined with propafenone have better clinical efficacy than the use of propafenone alone in the treatment of APB (OR = 3.89, 95% CI (2.03, 7.44), P < 0.0001, low-dose propafenone; OR = 4.24, 95% CI (1.32, 13.60), P = 0.02, high-dose propafenone). Propafenone 58-69 arginyl aminopeptidase Homo sapiens 154-157 32774412-7 2020 It has been identified that Wenxin granules combined with propafenone have better clinical efficacy than the use of propafenone alone in the treatment of APB (OR = 3.89, 95% CI (2.03, 7.44), P < 0.0001, low-dose propafenone; OR = 4.24, 95% CI (1.32, 13.60), P = 0.02, high-dose propafenone). Propafenone 116-127 arginyl aminopeptidase Homo sapiens 154-157 31829605-0 2020 Diazepam prodrug stabilizes human aminopeptidase B during lyophilization. Diazepam 0-8 arginyl aminopeptidase Homo sapiens 34-50 32119997-10 2020 Calcium chelators BAPTA-AM or APB, a specific inhibitor of IP3R, improved cell viability. Calcium 0-7 arginyl aminopeptidase Homo sapiens 18-33 32140260-0 2020 2-Aminoethoxydiphenylborate (2-APB) inhibits release of phosphatidylserine-exposing extracellular vesicles from platelets. 2-aminoethoxydiphenyl borate 0-27 arginyl aminopeptidase Homo sapiens 31-34 32140260-0 2020 2-Aminoethoxydiphenylborate (2-APB) inhibits release of phosphatidylserine-exposing extracellular vesicles from platelets. Phosphatidylserines 56-74 arginyl aminopeptidase Homo sapiens 31-34 32140260-8 2020 These data suggest that there is a further target of 2-APB, independent of cytosolic Ca2+ signalling, PS exposure and calpain activity, that is required for PS-exposing EV release. Phosphatidylserines 102-104 arginyl aminopeptidase Homo sapiens 55-58 32140260-8 2020 These data suggest that there is a further target of 2-APB, independent of cytosolic Ca2+ signalling, PS exposure and calpain activity, that is required for PS-exposing EV release. Phosphatidylserines 157-159 arginyl aminopeptidase Homo sapiens 55-58 32140260-10 2020 Identifying the target of 2-APB, DPBA and DP3A may provide a new way to inhibit PS-exposing EV release from activated platelets and inhibit their contribution to thrombosis and inflammation. Phosphatidylserines 80-82 arginyl aminopeptidase Homo sapiens 28-31 32678179-10 2020 When the ER-bound IP3 receptors were blocked by 2-APB (40 microM), we observed a delayed transient rise in [Ca2+]i as a response to the caspofungin. Caspofungin 136-147 arginyl aminopeptidase Homo sapiens 50-53 32236862-1 2020 Aminopeptidase B (APB, EC 3.4.11.6) preferentially hydrolyzes basic amino acids of synthetic substrates and requires a physiological concentration of chloride anions for optimal activity. Amino Acids, Basic 62-79 arginyl aminopeptidase Homo sapiens 0-16 32236862-1 2020 Aminopeptidase B (APB, EC 3.4.11.6) preferentially hydrolyzes basic amino acids of synthetic substrates and requires a physiological concentration of chloride anions for optimal activity. Amino Acids, Basic 62-79 arginyl aminopeptidase Homo sapiens 18-21 32236862-1 2020 Aminopeptidase B (APB, EC 3.4.11.6) preferentially hydrolyzes basic amino acids of synthetic substrates and requires a physiological concentration of chloride anions for optimal activity. Chlorides 150-158 arginyl aminopeptidase Homo sapiens 0-16 32236862-1 2020 Aminopeptidase B (APB, EC 3.4.11.6) preferentially hydrolyzes basic amino acids of synthetic substrates and requires a physiological concentration of chloride anions for optimal activity. Chlorides 150-158 arginyl aminopeptidase Homo sapiens 18-21 31829605-9 2020 Of the permutations, an APB+AVF+trehalose combination resulted in minimum degradation with 71% retention of activity. pro-diazepam 28-31 arginyl aminopeptidase Homo sapiens 24-27 31829605-6 2020 In this study, we demonstrate the use of the substrate avizafone (AVF), a prodrug for diazepam, as a stabilizer to minimize inactivation of APB during lyophilization. pro-diazepam 55-64 arginyl aminopeptidase Homo sapiens 140-143 31829605-6 2020 In this study, we demonstrate the use of the substrate avizafone (AVF), a prodrug for diazepam, as a stabilizer to minimize inactivation of APB during lyophilization. pro-diazepam 66-69 arginyl aminopeptidase Homo sapiens 140-143 31998070-6 2019 The non-vanilloid agonist 2-aminoethoxydiphenyl borate (2-APB) differs from that of capsaicin in the TRPV1 channel opening mechanism activating all S512F-mutated TRPV1 channels. 2-aminoethoxydiphenyl borate 26-54 arginyl aminopeptidase Homo sapiens 58-61 30928100-0 2019 The effects of curcumin, mangiferin, resveratrol and other natural plant products on aminopeptidase B activity. Curcumin 15-23 arginyl aminopeptidase Homo sapiens 85-101 31840506-4 2020 By utilizing a poly(Br-acrylate-alkyne) macroagent comprising alkynyl and 2-bromopropionate groups, we prepared a series of APB surfaces based on polyacrylate-g-poly(ethylene oxide)/poly(pentafluorophenyl methacrylate) (PA-g-PEO/PPFMA) APBs to explore the influence of the content of the fluorinated segment and bioinspired topological polymer chemistry on their antifouling performance. poly(br-acrylate-alkyne) 15-39 arginyl aminopeptidase Homo sapiens 124-127 31840506-4 2020 By utilizing a poly(Br-acrylate-alkyne) macroagent comprising alkynyl and 2-bromopropionate groups, we prepared a series of APB surfaces based on polyacrylate-g-poly(ethylene oxide)/poly(pentafluorophenyl methacrylate) (PA-g-PEO/PPFMA) APBs to explore the influence of the content of the fluorinated segment and bioinspired topological polymer chemistry on their antifouling performance. alkynyl and 2-bromopropionate 62-91 arginyl aminopeptidase Homo sapiens 124-127 31840506-4 2020 By utilizing a poly(Br-acrylate-alkyne) macroagent comprising alkynyl and 2-bromopropionate groups, we prepared a series of APB surfaces based on polyacrylate-g-poly(ethylene oxide)/poly(pentafluorophenyl methacrylate) (PA-g-PEO/PPFMA) APBs to explore the influence of the content of the fluorinated segment and bioinspired topological polymer chemistry on their antifouling performance. polyacrylate-g-poly(ethylene oxide) 146-181 arginyl aminopeptidase Homo sapiens 124-127 31840506-4 2020 By utilizing a poly(Br-acrylate-alkyne) macroagent comprising alkynyl and 2-bromopropionate groups, we prepared a series of APB surfaces based on polyacrylate-g-poly(ethylene oxide)/poly(pentafluorophenyl methacrylate) (PA-g-PEO/PPFMA) APBs to explore the influence of the content of the fluorinated segment and bioinspired topological polymer chemistry on their antifouling performance. poly(pentafluorophenyl methacrylate) 182-218 arginyl aminopeptidase Homo sapiens 124-127 31840506-4 2020 By utilizing a poly(Br-acrylate-alkyne) macroagent comprising alkynyl and 2-bromopropionate groups, we prepared a series of APB surfaces based on polyacrylate-g-poly(ethylene oxide)/poly(pentafluorophenyl methacrylate) (PA-g-PEO/PPFMA) APBs to explore the influence of the content of the fluorinated segment and bioinspired topological polymer chemistry on their antifouling performance. pa-g-peo 220-228 arginyl aminopeptidase Homo sapiens 124-127 31840506-4 2020 By utilizing a poly(Br-acrylate-alkyne) macroagent comprising alkynyl and 2-bromopropionate groups, we prepared a series of APB surfaces based on polyacrylate-g-poly(ethylene oxide)/poly(pentafluorophenyl methacrylate) (PA-g-PEO/PPFMA) APBs to explore the influence of the content of the fluorinated segment and bioinspired topological polymer chemistry on their antifouling performance. ppfma 229-234 arginyl aminopeptidase Homo sapiens 124-127 31840506-4 2020 By utilizing a poly(Br-acrylate-alkyne) macroagent comprising alkynyl and 2-bromopropionate groups, we prepared a series of APB surfaces based on polyacrylate-g-poly(ethylene oxide)/poly(pentafluorophenyl methacrylate) (PA-g-PEO/PPFMA) APBs to explore the influence of the content of the fluorinated segment and bioinspired topological polymer chemistry on their antifouling performance. tert-butoxycarbonyl-trimethylsilylalanyl-prolyl-boro-methoxypropylglycine-pinanediol 236-240 arginyl aminopeptidase Homo sapiens 124-127 30837282-8 2019 Our results demonstrate that diazepam, which is practically insoluble, can be delivered intranasally with rapid and complete absorption by coadministering avizafone with aminopeptidase B. Diazepam 29-37 arginyl aminopeptidase Homo sapiens 170-186 31947967-4 2020 We first demonstrated that the TRPM7 inhibitors 2-aminoethyl diphenylborinate (2-APB), ginsenoside Rd (Gin Rd), and waixenicin A preferentially suppressed the viability of human embryonic kidney HEK293 overexpressing TRPM7 (HEK-M7) cells over wildtype HEK293 (WT-HEK). 2-aminoethyl diphenylborinate 48-77 arginyl aminopeptidase Homo sapiens 81-84 31654521-3 2020 OBJECTIVE: To review the effects of 2-Aminoethyldiphenyl borinate (2-APB), an organoboron compound, on the human body. Aligeron 36-65 arginyl aminopeptidase Homo sapiens 69-72 31654521-3 2020 OBJECTIVE: To review the effects of 2-Aminoethyldiphenyl borinate (2-APB), an organoboron compound, on the human body. organoboron 78-89 arginyl aminopeptidase Homo sapiens 69-72 31654521-7 2020 Additionally, reports show that 2-APB exerts effects on neurons, smooth muscle cells and cardiomyocytes, and it provides a cytoprotective effect by modulation and attenuation of reactive oxygen species. Oxygen 187-193 arginyl aminopeptidase Homo sapiens 34-37 31680972-7 2019 We show that co-application of either cannabidiol (CBD) or 2-APB, the activators of TRPV2 channels, together with doxorubicin leads to significantly higher accumulation of doxorubicin in BNL1 ME cells than in BNL1 ME cells that were exposed to doxorubicin alone. Doxorubicin 172-183 arginyl aminopeptidase Homo sapiens 61-64 31680972-7 2019 We show that co-application of either cannabidiol (CBD) or 2-APB, the activators of TRPV2 channels, together with doxorubicin leads to significantly higher accumulation of doxorubicin in BNL1 ME cells than in BNL1 ME cells that were exposed to doxorubicin alone. Doxorubicin 172-183 arginyl aminopeptidase Homo sapiens 61-64 31680972-8 2019 Moreover, we demonstrate that sub-effective doses of doxorubicin when co-applied with either 2-APB or CBD lead to a significant decrease in the number of living BNL1 ME cell and BNL1 ME cell colonies in comparison to application of doxorubicin alone. Doxorubicin 53-64 arginyl aminopeptidase Homo sapiens 95-98 31680972-9 2019 Finally, we demonstrate that the doxorubicin-mediated cell death is significantly more potent, requiring an order of magnitude lower dose, when co-applied with CBD than with 2-APB. Doxorubicin 33-44 arginyl aminopeptidase Homo sapiens 176-179 30928100-0 2019 The effects of curcumin, mangiferin, resveratrol and other natural plant products on aminopeptidase B activity. mangiferin 25-35 arginyl aminopeptidase Homo sapiens 85-101 30928100-0 2019 The effects of curcumin, mangiferin, resveratrol and other natural plant products on aminopeptidase B activity. Resveratrol 37-48 arginyl aminopeptidase Homo sapiens 85-101 30928100-4 2019 As the activities of LTA4H are reported to be inhibited by resveratrol, a polyphenolic molecule from red wine, the effect of this molecule was investigated on the Ap-B activity. Resveratrol 59-70 arginyl aminopeptidase Homo sapiens 163-167 30602948-6 2018 This effect was reduced by indomethacin (2 x 10-6 M), yohimbine (2 x 10-6 M) and 2-aminoethoxydiphenyl borate (2-APB) (5 x 10-5 M), but not by atropine (3.45 x 10-8 M) and cholesterol (2.5 mg/ml). 2-aminoethoxydiphenyl borate 81-109 arginyl aminopeptidase Homo sapiens 113-116 30429472-4 2018 Here, we present the cryo-electron microscopy structures of apo and sensitized human TRPV3, as well as several structures of TRPV3 in the presence of the common thermoTRPV agonist 2-aminoethoxydiphenyl borate (2-APB). 2-aminoethoxydiphenyl borate 180-208 arginyl aminopeptidase Homo sapiens 212-215 30602948-6 2018 This effect was reduced by indomethacin (2 x 10-6 M), yohimbine (2 x 10-6 M) and 2-aminoethoxydiphenyl borate (2-APB) (5 x 10-5 M), but not by atropine (3.45 x 10-8 M) and cholesterol (2.5 mg/ml). Atropine 143-151 arginyl aminopeptidase Homo sapiens 113-116 30602948-6 2018 This effect was reduced by indomethacin (2 x 10-6 M), yohimbine (2 x 10-6 M) and 2-aminoethoxydiphenyl borate (2-APB) (5 x 10-5 M), but not by atropine (3.45 x 10-8 M) and cholesterol (2.5 mg/ml). Cholesterol 172-183 arginyl aminopeptidase Homo sapiens 113-116 29373553-5 2018 Using this glioma model, here we analyze the effects of the phenolic compounds oleuropein and hydroxytyrosol in circulating RAS-regulating ASAP, APA, APN, APB and IRAP specific activities and the pro-inflammatory cytokines IL-6 and TNFalpha to understand the relationship between the antitumor and anti-inflammatory effects of hydroxytyrosol, but not oleuropein, and the components of the RAS. 3,4-dihydroxyphenylethanol 94-108 arginyl aminopeptidase Homo sapiens 155-158 29604959-3 2018 Cellular responses to nucleotides were insignificantly sensitive to bath Ca2+, pointing at a minor contribution of Ca2+ entry, and were suppressed by U73122 and 2-APB, implicating the phosphoinositide cascade in coupling P2Y receptors to Ca2+ release. Phosphatidylinositols 184-200 arginyl aminopeptidase Homo sapiens 163-166 30895246-6 2018 The Sr2+ (10 mM) and TRPV3 agonists (200 muM 2-aminoethoxydiphenyl borate [2-APB] and 200 muM carvacrol)-induced Ca2+ response was analyzed in human (n = 15, n = 16 and n = 16, respectively) and mouse oocytes (n = 15, n = 19 and n = 26, respectively). strontium cation 4-8 arginyl aminopeptidase Homo sapiens 77-80 30895246-6 2018 The Sr2+ (10 mM) and TRPV3 agonists (200 muM 2-aminoethoxydiphenyl borate [2-APB] and 200 muM carvacrol)-induced Ca2+ response was analyzed in human (n = 15, n = 16 and n = 16, respectively) and mouse oocytes (n = 15, n = 19 and n = 26, respectively). 2-aminoethoxydiphenyl borate 45-73 arginyl aminopeptidase Homo sapiens 77-80 29255188-3 2017 By using the state-of-art molecular simulations with polarization effect implicitly or explicitly included, we studied the permeation behavior of 2-aminoethoxydiphenyl borate (2-APB), a broad-spectrum modulator for a number of membrane proteins. 2-aminoethoxydiphenyl borate 146-174 arginyl aminopeptidase Homo sapiens 178-181 27692399-8 2017 Significant inhibition of the Ach-induced ATP release was also observed by the addition of 1muM atropine, 40muM 2-APB, 10muM CBX, and 100muM PPADS, whereas 30nM bafilomycin A1 did not affect the ATP release. Acetylcholine 30-33 arginyl aminopeptidase Homo sapiens 114-117 28710651-3 2017 After a urinary immunoassay screening which gave a positivity to amphetamines, general unknown gas chromatography-mass spectrometry (GC-MS) urine analysis identified 5-(2-methylaminopropyl)benzofuran (5-MAPB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), ethylphenidate, and ritalinic acid. 5-(2-methylaminopropyl)benzofuran 166-199 arginyl aminopeptidase Homo sapiens 204-207 27692399-8 2017 Significant inhibition of the Ach-induced ATP release was also observed by the addition of 1muM atropine, 40muM 2-APB, 10muM CBX, and 100muM PPADS, whereas 30nM bafilomycin A1 did not affect the ATP release. Adenosine Triphosphate 42-45 arginyl aminopeptidase Homo sapiens 114-117 28111173-16 2017 The InsP3R antagonists 2-aminoethoxydiphenyl borate (2-APB; 3muM) and xestospongin C (XeC; 50muM) dramatically reduced their frequency. 2-aminoethoxydiphenyl borate 23-51 arginyl aminopeptidase Homo sapiens 55-58 28249687-0 2017 Activation of endoplasmic reticulum calcium leak by 2-APB depends on the luminal calcium concentration. Calcium 36-43 arginyl aminopeptidase Homo sapiens 54-57 28249687-0 2017 Activation of endoplasmic reticulum calcium leak by 2-APB depends on the luminal calcium concentration. Calcium 81-88 arginyl aminopeptidase Homo sapiens 54-57 28249687-4 2017 Interestingly, this effect of 2-APB of reducing the [Ca2+]ER is auto-limited because depends on a replete ER Ca2+ store; a condition that thapsigargin does not require to decrease the [Ca2+]ER. Thapsigargin 138-150 arginyl aminopeptidase Homo sapiens 32-35 28196740-2 2017 To study its physiological role, pharmacological tools, like 2-aminoethyl diphenylborinate (2-APB), are used to impact SOCE. 2-aminoethyl diphenylborinate 61-90 arginyl aminopeptidase Homo sapiens 94-97 28196740-6 2017 The recently developed DPB162-AE is such a structural diphenylborinate isomer of 2-APB that selectively inhibits SOCE currents by blocking the functional coupling between STIM1 and Orai1. DPB162-AE 23-32 arginyl aminopeptidase Homo sapiens 83-86 28196740-6 2017 The recently developed DPB162-AE is such a structural diphenylborinate isomer of 2-APB that selectively inhibits SOCE currents by blocking the functional coupling between STIM1 and Orai1. diphenylborinate 54-70 arginyl aminopeptidase Homo sapiens 83-86 27502147-1 2016 Although 5-(2-aminopropyl)benzofuran (5-APB) and 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (phenazepam) are being used as recreational drugs, research on their dependence liability or mechanisms of action is lacking. 5-(2-aminopropyl)benzofuran 9-36 arginyl aminopeptidase Homo sapiens 40-43 27859755-2 2017 In this research, the achiral amphiphile 1-[11-(2-anthracenylmethoxy)-11-oxoundecyl]pyridinium bromide (2-APB), in which the hydrophobic anthracene and the hydrophilic pyridinium units are linked by alkyl chains, was found to form chiral supramolecular assemblies in a cooperative manner in the presence of iodide anion. 1-[11-(2-anthracenylmethoxy)-11-oxoundecyl]pyridinium bromide 41-102 arginyl aminopeptidase Homo sapiens 106-109 27859755-2 2017 In this research, the achiral amphiphile 1-[11-(2-anthracenylmethoxy)-11-oxoundecyl]pyridinium bromide (2-APB), in which the hydrophobic anthracene and the hydrophilic pyridinium units are linked by alkyl chains, was found to form chiral supramolecular assemblies in a cooperative manner in the presence of iodide anion. anthracene 137-147 arginyl aminopeptidase Homo sapiens 106-109 27859755-2 2017 In this research, the achiral amphiphile 1-[11-(2-anthracenylmethoxy)-11-oxoundecyl]pyridinium bromide (2-APB), in which the hydrophobic anthracene and the hydrophilic pyridinium units are linked by alkyl chains, was found to form chiral supramolecular assemblies in a cooperative manner in the presence of iodide anion. pyridine 84-94 arginyl aminopeptidase Homo sapiens 106-109 27859755-2 2017 In this research, the achiral amphiphile 1-[11-(2-anthracenylmethoxy)-11-oxoundecyl]pyridinium bromide (2-APB), in which the hydrophobic anthracene and the hydrophilic pyridinium units are linked by alkyl chains, was found to form chiral supramolecular assemblies in a cooperative manner in the presence of iodide anion. Iodides 307-319 arginyl aminopeptidase Homo sapiens 106-109 27859755-4 2017 By using the same method, 2-APB could assemble together with other pseudo-halogen anions (OCN- , SCN- , SeCN- ) that have similar anionic radius as iodide to form chiral structures. Halogens 74-81 arginyl aminopeptidase Homo sapiens 28-31 27859755-4 2017 By using the same method, 2-APB could assemble together with other pseudo-halogen anions (OCN- , SCN- , SeCN- ) that have similar anionic radius as iodide to form chiral structures. Iodides 148-154 arginyl aminopeptidase Homo sapiens 28-31 26508031-11 2016 Together, in ZR-75-1 cells, esculetin induced [Ca(2+)]i rises by releasing Ca(2+) from the ER and causing Ca(2+) influx through 2-APB-sensitive store-operated Ca(2+) entry. esculetin 28-37 arginyl aminopeptidase Homo sapiens 130-133 27373367-1 2016 2-Aminoethoxydiphenyl borate (2-APB) elicits potentiation current (Ip) on Ca(2+) release-activated Ca(2+) (CRAC) channels. 2-aminoethoxydiphenyl borate 0-28 arginyl aminopeptidase Homo sapiens 32-35 27373367-5 2016 On the contrary, large Cs(+) ions blocked the WT channels, while displayed large 2-APB induced Ip on pore-enlarged Orai1-V102C/A/G mutant channels, and the potentiation ratio was highest on Orai1-V102C with an intermediate pore size. Cesium 23-25 arginyl aminopeptidase Homo sapiens 83-86 27373367-6 2016 Furthermore, we showed that 2-APB potentiated Cs(+) current on constitutively active Orai1-V102C/A/G mutants independent of STIM1. Cesium 46-48 arginyl aminopeptidase Homo sapiens 30-33 26508031-6 2016 In ZR-75-1 cells, this Ca(2+) signal response was reduced by removing extracellular Ca(2+) and was inhibited by the store-operated Ca(2+) channel blocker 2-aminoethoxydiphenyl borate (2-APB). 2-aminoethoxydiphenyl borate 154-182 arginyl aminopeptidase Homo sapiens 186-189 26508031-14 2016 The natural coumarin derivative esculetin caused Ca(2+) influx via 2-APB-sensitive store-operated Ca(2+) entry and induced Ca(2+) release from the endoplasmic reticulum. coumarin 12-20 arginyl aminopeptidase Homo sapiens 69-72 26508031-14 2016 The natural coumarin derivative esculetin caused Ca(2+) influx via 2-APB-sensitive store-operated Ca(2+) entry and induced Ca(2+) release from the endoplasmic reticulum. esculetin 32-41 arginyl aminopeptidase Homo sapiens 69-72 25438992-8 2015 Pharmacological inhibition of TRPM7 channel with 2-aminoethoxydiphenyl borate (2-APB) showed a similar effect as TRPM7-siRNA. 2-aminoethoxydiphenyl borate 49-77 arginyl aminopeptidase Homo sapiens 81-84 26351197-5 2016 Individual factors influencing BPb values were, in the order of decreasing importance, Pb in ambient air (APb), alcohol consumption, age, and smoking. Lead 32-34 arginyl aminopeptidase Homo sapiens 106-109 26473577-1 2015 2-Aminoethoxydiphenylborate (2-APB) is a broad-spectrum modulator of various membrane proteins. 2-aminoethoxydiphenyl borate 0-27 arginyl aminopeptidase Homo sapiens 31-34 26473577-2 2015 Specifically, it exhibits concentration dependent modulation of calcium signaling through store-operated calcium (SOC) channels: low micromolar concentration of 2-APB stimulates SOC entry while a higher concentration induces complete inhibition. Calcium 64-71 arginyl aminopeptidase Homo sapiens 163-166 26352190-0 2015 Involvement of Phenylalanine 297 in the Construction of the Substrate Pocket of Human Aminopeptidase B. Phenylalanine 15-28 arginyl aminopeptidase Homo sapiens 86-102 26352190-1 2015 Aminopeptidase B (APB, EC 3.4.11.6) preferentially hydrolyzes the N-terminal basic amino acids of synthetic and peptide substrates and requires a physiological concentration of NaCl for optimal activity. Amino Acids, Basic 77-94 arginyl aminopeptidase Homo sapiens 0-16 26352190-1 2015 Aminopeptidase B (APB, EC 3.4.11.6) preferentially hydrolyzes the N-terminal basic amino acids of synthetic and peptide substrates and requires a physiological concentration of NaCl for optimal activity. Amino Acids, Basic 77-94 arginyl aminopeptidase Homo sapiens 18-21 26352190-1 2015 Aminopeptidase B (APB, EC 3.4.11.6) preferentially hydrolyzes the N-terminal basic amino acids of synthetic and peptide substrates and requires a physiological concentration of NaCl for optimal activity. Sodium Chloride 177-181 arginyl aminopeptidase Homo sapiens 0-16 26352190-1 2015 Aminopeptidase B (APB, EC 3.4.11.6) preferentially hydrolyzes the N-terminal basic amino acids of synthetic and peptide substrates and requires a physiological concentration of NaCl for optimal activity. Sodium Chloride 177-181 arginyl aminopeptidase Homo sapiens 18-21 26352190-4 2015 Molecular modeling suggests that Phe297 contributes to the construction of the substrate pocket of APB, which is wide enough to hold a chloride anion and allow the interaction of Gln169 with the N-terminal Arg residue of the substrate through bridging with the chloride anion. Chlorides 135-149 arginyl aminopeptidase Homo sapiens 99-102 26352190-4 2015 Molecular modeling suggests that Phe297 contributes to the construction of the substrate pocket of APB, which is wide enough to hold a chloride anion and allow the interaction of Gln169 with the N-terminal Arg residue of the substrate through bridging with the chloride anion. Arginine 206-209 arginyl aminopeptidase Homo sapiens 99-102 26352190-4 2015 Molecular modeling suggests that Phe297 contributes to the construction of the substrate pocket of APB, which is wide enough to hold a chloride anion and allow the interaction of Gln169 with the N-terminal Arg residue of the substrate through bridging with the chloride anion. Chlorides 261-275 arginyl aminopeptidase Homo sapiens 99-102 26352190-5 2015 These results indicate that Phe297 is crucial for the optimal enzymatic activity and chloride anion sensitivity of APB via formation of the optimal structure of the catalytic pocket. Chlorides 85-99 arginyl aminopeptidase Homo sapiens 115-118 25752528-9 2015 Consistent with the broad gating effect on TRPV1-4 channels, evidence from the present study hints that NA may share the same activation pathway as 2-aminoethoxydiphenyl borate (2-APB), a common agonist for these TRPV channels. 2-aminoethoxydiphenyl borate 148-176 arginyl aminopeptidase Homo sapiens 180-183 26876731-7 2016 Using (1)H-nuclear magnetic resonance to examine the solution structures of 2-APB and its analogs, we observed striking structural differences of the boron-containing compounds at neutral/basic as compared to acidic pH, suggesting that a pH-dependent configuration switch of 2-APB-based drugs may underlie their functionality. Boron 150-155 arginyl aminopeptidase Homo sapiens 78-81 26876731-7 2016 Using (1)H-nuclear magnetic resonance to examine the solution structures of 2-APB and its analogs, we observed striking structural differences of the boron-containing compounds at neutral/basic as compared to acidic pH, suggesting that a pH-dependent configuration switch of 2-APB-based drugs may underlie their functionality. Boron 150-155 arginyl aminopeptidase Homo sapiens 277-280 26712122-4 2016 In MT-2 T cells, APV-PEG3.4 kDa-FITC (APF) anti-HIV-1 activity was significantly reduced (160-fold, IC50 = 8064 nM) due to poor cell uptake, whereas it was restored (IC50 = 78.29 nM) and similar to APV (IC50 = 50.29 nM) with the addition of Bac7 to the NC (i.e., APV-PEG3.4 kDa-Bac7, APB). apv-peg3 17-25 arginyl aminopeptidase Homo sapiens 284-287 26712122-4 2016 In MT-2 T cells, APV-PEG3.4 kDa-FITC (APF) anti-HIV-1 activity was significantly reduced (160-fold, IC50 = 8064 nM) due to poor cell uptake, whereas it was restored (IC50 = 78.29 nM) and similar to APV (IC50 = 50.29 nM) with the addition of Bac7 to the NC (i.e., APV-PEG3.4 kDa-Bac7, APB). kda-fitc 28-36 arginyl aminopeptidase Homo sapiens 284-287 26712122-4 2016 In MT-2 T cells, APV-PEG3.4 kDa-FITC (APF) anti-HIV-1 activity was significantly reduced (160-fold, IC50 = 8064 nM) due to poor cell uptake, whereas it was restored (IC50 = 78.29 nM) and similar to APV (IC50 = 50.29 nM) with the addition of Bac7 to the NC (i.e., APV-PEG3.4 kDa-Bac7, APB). apf 38-41 arginyl aminopeptidase Homo sapiens 284-287 26712122-4 2016 In MT-2 T cells, APV-PEG3.4 kDa-FITC (APF) anti-HIV-1 activity was significantly reduced (160-fold, IC50 = 8064 nM) due to poor cell uptake, whereas it was restored (IC50 = 78.29 nM) and similar to APV (IC50 = 50.29 nM) with the addition of Bac7 to the NC (i.e., APV-PEG3.4 kDa-Bac7, APB). amprenavir 17-20 arginyl aminopeptidase Homo sapiens 284-287 26530501-3 2015 In Europe, frequently detected NPS are 4-bromo-2,5-dimethoxyphenethylamine (2C-B), 4-fluoroamphetamine (4-FA) and benzofurans (5-(2-aminopropyl)benzofuran (5-APB) or 6-(2-aminopropyl)benzofuran (6-APB)). 5-(2-aminopropyl)benzofuran 127-154 arginyl aminopeptidase Homo sapiens 158-161 26530501-3 2015 In Europe, frequently detected NPS are 4-bromo-2,5-dimethoxyphenethylamine (2C-B), 4-fluoroamphetamine (4-FA) and benzofurans (5-(2-aminopropyl)benzofuran (5-APB) or 6-(2-aminopropyl)benzofuran (6-APB)). 5-(2-aminopropyl)benzofuran 127-154 arginyl aminopeptidase Homo sapiens 197-200 26530501-5 2015 METHODS: In this paper, existing literature on the pharmacokinetics and pharmacodynamics of 2C-B, 4-FA and benzofurans (5-APB/6-APB) was reviewed. 2-(4-bromo-2,5-dimethoxyphenyl)ethylamine 92-96 arginyl aminopeptidase Homo sapiens 122-125 26530501-5 2015 METHODS: In this paper, existing literature on the pharmacokinetics and pharmacodynamics of 2C-B, 4-FA and benzofurans (5-APB/6-APB) was reviewed. 2-(4-bromo-2,5-dimethoxyphenyl)ethylamine 92-96 arginyl aminopeptidase Homo sapiens 128-131 26530501-5 2015 METHODS: In this paper, existing literature on the pharmacokinetics and pharmacodynamics of 2C-B, 4-FA and benzofurans (5-APB/6-APB) was reviewed. Benzofurans 107-118 arginyl aminopeptidase Homo sapiens 122-125 26530501-5 2015 METHODS: In this paper, existing literature on the pharmacokinetics and pharmacodynamics of 2C-B, 4-FA and benzofurans (5-APB/6-APB) was reviewed. Benzofurans 107-118 arginyl aminopeptidase Homo sapiens 128-131 26530501-6 2015 RESULTS: Our review showed that the clinical effects of 2C-B, 4-FA and benzofurans (5-APB/6-APB) are comparable with common illicit drugs like amphetamine and 3,4-methylenedioxymethamphetamine (MDMA). 2-(4-bromo-2,5-dimethoxyphenyl)ethylamine 56-60 arginyl aminopeptidase Homo sapiens 86-89 26530501-6 2015 RESULTS: Our review showed that the clinical effects of 2C-B, 4-FA and benzofurans (5-APB/6-APB) are comparable with common illicit drugs like amphetamine and 3,4-methylenedioxymethamphetamine (MDMA). 2-(4-bromo-2,5-dimethoxyphenyl)ethylamine 56-60 arginyl aminopeptidase Homo sapiens 92-95 26530501-6 2015 RESULTS: Our review showed that the clinical effects of 2C-B, 4-FA and benzofurans (5-APB/6-APB) are comparable with common illicit drugs like amphetamine and 3,4-methylenedioxymethamphetamine (MDMA). 4-fluoroamphetamine 62-66 arginyl aminopeptidase Homo sapiens 86-89 26530501-6 2015 RESULTS: Our review showed that the clinical effects of 2C-B, 4-FA and benzofurans (5-APB/6-APB) are comparable with common illicit drugs like amphetamine and 3,4-methylenedioxymethamphetamine (MDMA). 4-fluoroamphetamine 62-66 arginyl aminopeptidase Homo sapiens 92-95 26530501-6 2015 RESULTS: Our review showed that the clinical effects of 2C-B, 4-FA and benzofurans (5-APB/6-APB) are comparable with common illicit drugs like amphetamine and 3,4-methylenedioxymethamphetamine (MDMA). Benzofurans 71-82 arginyl aminopeptidase Homo sapiens 86-89 26530501-6 2015 RESULTS: Our review showed that the clinical effects of 2C-B, 4-FA and benzofurans (5-APB/6-APB) are comparable with common illicit drugs like amphetamine and 3,4-methylenedioxymethamphetamine (MDMA). Benzofurans 71-82 arginyl aminopeptidase Homo sapiens 92-95 25982558-1 2015 2-Aminoethoxydiphenyl borate (2-APB) has been recently identified as a common agonist of TWIK-related K(+) channel (TREK)/TRAAK channels, a subfamily of two-pore domain K(+) (K2P) channels. 2-aminoethoxydiphenyl borate 0-28 arginyl aminopeptidase Homo sapiens 32-35 25429871-0 2015 Acute 5-(2-aminopropyl)benzofuran (5-APB) intoxication and fatality: a case report with postmortem concentrations. 5-(2-aminopropyl)benzofuran 6-33 arginyl aminopeptidase Homo sapiens 37-40 25429871-6 2015 An alkaline drug screen detected 5-(2-aminopropyl)benzofuran (5-APB) which was subsequently confirmed and quantified by a specific GC-MS SIM analysis following solid-phase extraction. 5-(2-aminopropyl)benzofuran 33-60 arginyl aminopeptidase Homo sapiens 64-67 25530263-0 2015 The M1 family of vertebrate aminopeptidases: role of evolutionarily conserved tyrosines in the enzymatic mechanism of aminopeptidase B. Tyrosine 78-87 arginyl aminopeptidase Homo sapiens 118-134 25089200-0 2014 Drofenine: A 2-APB Analogue with Greater Selectivity for Human TRPV3. cycloadiphenine 0-9 arginyl aminopeptidase Homo sapiens 15-18 25308862-6 2014 The degree of stretching of the tethered copolymer chains gradually grows with the increase of aPA or aPB, while the degree of stretching of solvophobic block B decreases when the morphologies change from spherical to disk-like micelles and further to rod-like micelles. copolymer 41-50 arginyl aminopeptidase Homo sapiens 102-105 25308862-4 2014 When the repulsive interaction between block copolymers and nanoparticles aPA = aPB = 25, the nanoparticles are evenly distributed within the spherical micelles. copolymers 45-55 arginyl aminopeptidase Homo sapiens 80-83 25447185-0 2014 Fatal intoxication with 3-methyl-N-methylcathinone (3-MMC) and 5-(2-aminopropyl)benzofuran (5-APB). 5-(2-aminopropyl)benzofuran 63-90 arginyl aminopeptidase Homo sapiens 94-97 25089200-5 2014 Drofenine exhibited similar potency to the known TRPV3 agonists 2-aminoethoxydiphenylboronate (2-APB) and carvacrol in HEK-293 cells, but greater selectivity for TRPV3 based on a lack of activation of TRPA1, V1, V2, V4, or M8. cycloadiphenine 0-9 arginyl aminopeptidase Homo sapiens 97-100 25089200-7 2014 Drofenine activated TRPV3 via interactions with the residue, H426, which is required for TRPV3 activation by 2-APB. cycloadiphenine 0-9 arginyl aminopeptidase Homo sapiens 111-114 25089200-7 2014 Drofenine activated TRPV3 via interactions with the residue, H426, which is required for TRPV3 activation by 2-APB. (R)-N-(tert-butoxycarbonyl)-beta-phenyl-phenylalaninol 61-65 arginyl aminopeptidase Homo sapiens 111-114 23627317-1 2014 Two series of compounds (AB and APB) bearing substituted phenoxy groups at 2-position of benzimidazole nucleus through amino or phenyleneamino were synthesized and evaluated through PASS software for predicting the activity spectrum of each compound. benzimidazole 89-102 arginyl aminopeptidase Homo sapiens 32-35 24628114-7 2014 2-aminoethoxydiphenyl borate (2-APB) and high concentrations of caffeine selectively inhibited IP3R1 without affecting IP3 binding. 2-aminoethoxydiphenyl borate 0-28 arginyl aminopeptidase Homo sapiens 32-35 24628114-7 2014 2-aminoethoxydiphenyl borate (2-APB) and high concentrations of caffeine selectively inhibited IP3R1 without affecting IP3 binding. Inositol 1,4,5-Trisphosphate 95-98 arginyl aminopeptidase Homo sapiens 32-35 24412328-0 2014 Role of glutamine-169 in the substrate recognition of human aminopeptidase B. Glutamine 8-17 arginyl aminopeptidase Homo sapiens 60-76 24412328-1 2014 BACKGROUND: Aminopeptidase B (EC 3.4.11.6, APB) preferentially hydrolyzes N-terminal basic amino acids of synthetic and peptide substrates. Amino Acids, Basic 85-102 arginyl aminopeptidase Homo sapiens 12-28 24412328-1 2014 BACKGROUND: Aminopeptidase B (EC 3.4.11.6, APB) preferentially hydrolyzes N-terminal basic amino acids of synthetic and peptide substrates. Amino Acids, Basic 85-102 arginyl aminopeptidase Homo sapiens 43-46 24412328-2 2014 APB is involved in the production and maturation of peptide hormones and neurotransmitters such as miniglucagon, cholecystokinin and enkephalin by cleaving N-terminal basic amino acids in extended precursor proteins. Amino Acids, Basic 167-184 arginyl aminopeptidase Homo sapiens 0-3 24412328-3 2014 Therefore, the specificity for basic amino acids is crucial for the biological function of APB. Amino Acids, Basic 31-48 arginyl aminopeptidase Homo sapiens 91-94 24412328-4 2014 METHODS: Site-directed mutagenesis and molecular modeling of the S1 site were used to identify amino acid residues of the human APB responsible for the basic amino acid preference and enzymatic efficiency. Amino Acids, Basic 152-168 arginyl aminopeptidase Homo sapiens 128-131 24412328-6 2014 Substantial retardation of enzyme activity was observed toward Arg-MCA and substitution with Glu caused complete loss of enzymatic activity of APB. Arginine 63-66 arginyl aminopeptidase Homo sapiens 143-146 24412328-6 2014 Substantial retardation of enzyme activity was observed toward Arg-MCA and substitution with Glu caused complete loss of enzymatic activity of APB. Glutamic Acid 93-96 arginyl aminopeptidase Homo sapiens 143-146 24412328-7 2014 Substitution with Asn led to an increase in IC50 values of inhibitors that interact with the catalytic pocket of APB. Asparagine 18-21 arginyl aminopeptidase Homo sapiens 113-116 24412328-11 2014 CONCLUSION: Gln169 is crucial for obtaining optimal enzymatic activity and the unique basic amino acid preference of APB via maintaining the appropriate catalytic pocket structure and thus for its function as a processing enzyme of peptide hormones and neurotransmitters. Amino Acids, Basic 86-102 arginyl aminopeptidase Homo sapiens 117-120 23627317-6 2014 The compound with p-chlorophenoxy moiety was the most active from the APB series (mortality time 5.7+-0.4 min and paralysis time 3.1+-0.3 min) and equipotent to albendazole (mortality time 5.4+-0.1 min and paralysis time 2.8+-0.2 min) at concentration of 0.2%. chlorophenoxy 20-33 arginyl aminopeptidase Homo sapiens 70-73 24636300-9 2013 Both intervention treatments, EGTA and 2-APB, significantly reduced the 200 mM ethanol treatment-induced [Ca2+]i increase (2.32+/-0.08 reduced to 1.79+/-0.15 (t = 7.201, P less than 0.01) and 1.86+/-0.09 (t = 8.183, P less than 0.01) respectively). Ethanol 79-86 arginyl aminopeptidase Homo sapiens 41-44 24295715-7 2013 Ca2+ levels from neutrophils obtained after diclofenac treatment were further decreased after incubation with V+D or 2-APB, compared with those exposed to neither agent. Diclofenac 44-54 arginyl aminopeptidase Homo sapiens 119-122 24733836-0 2014 State-dependent block of Orai3 TM1 and TM3 cysteine mutants: insights into 2-APB activation. Cysteine 43-51 arginyl aminopeptidase Homo sapiens 77-80 24733836-2 2014 Of the three human Orai channel homologues, only Orai3 can be activated by high concentrations (>50 microM) of 2-aminoethyl diphenylborinate (2-APB). 2-aminoethyl diphenylborinate 114-143 arginyl aminopeptidase Homo sapiens 147-150 24733836-4 2014 Here we use cysteine scanning mutagenesis, thiol-reactive reagents, and patch-clamp analysis to define the residues that assist in formation of the 2-APB-activated Orai3 pore. Cysteine 12-20 arginyl aminopeptidase Homo sapiens 150-153 24733836-4 2014 Here we use cysteine scanning mutagenesis, thiol-reactive reagents, and patch-clamp analysis to define the residues that assist in formation of the 2-APB-activated Orai3 pore. Sulfhydryl Compounds 43-48 arginyl aminopeptidase Homo sapiens 150-153 24636300-10 2013 EGTA and 2-APB also increased the ethanol-treated cells" viability and reduced the ALT and AST leakage. Ethanol 34-41 arginyl aminopeptidase Homo sapiens 11-14 23733714-0 2013 Acute psychosis associated with recreational use of benzofuran 6-(2-aminopropyl)benzofuran (6-APB) and cannabis. benzofuran 6-(2-aminopropyl)benzofuran 52-90 arginyl aminopeptidase Homo sapiens 94-97 24331698-4 2013 The possible role of these two SOCs proteins in the ethanol-induced extracellular calcium influx and related liver cell injury was determined by treating the cell system with various channel blockers (EGTA, La3+, and 2-APB). Ethanol 52-59 arginyl aminopeptidase Homo sapiens 219-222 24331698-4 2013 The possible role of these two SOCs proteins in the ethanol-induced extracellular calcium influx and related liver cell injury was determined by treating the cell system with various channel blockers (EGTA, La3+, and 2-APB). Calcium 82-89 arginyl aminopeptidase Homo sapiens 219-222 23974726-5 2013 Using calcium imaging technology, we first found that SOC channels blockers, 1-[h-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole (SKF-96365) and 2-aminoethyldiphenyl borate (2-APB), inhibited LPS induced [Ca(2+)]i increase, which prompted us to speculate that SOC channels may be involved in LPS induced astrocyte activation. Calcium 6-13 arginyl aminopeptidase Homo sapiens 191-194 23974726-5 2013 Using calcium imaging technology, we first found that SOC channels blockers, 1-[h-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole (SKF-96365) and 2-aminoethyldiphenyl borate (2-APB), inhibited LPS induced [Ca(2+)]i increase, which prompted us to speculate that SOC channels may be involved in LPS induced astrocyte activation. 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole 145-154 arginyl aminopeptidase Homo sapiens 191-194 23733714-1 2013 INTRODUCTION: There is evidence from around Europe of the availability and use of 6-(2-aminopropyl)benzofuran (6-APB) as a recreational drug. 6-(2-aminopropyl)benzofuran 82-109 arginyl aminopeptidase Homo sapiens 113-116 23733714-3 2013 We describe here a case of acute toxicity associated with recreational use of legal high (6-APB) and cannabis, in which the comprehensive toxicological analysis confirmed the presence of a significant amount of 6-APB together with metabolites of both tetrahydrocannabinol and the synthetic cannabinoid receptor agonist (JWH-122). (4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone 320-327 arginyl aminopeptidase Homo sapiens 92-95 23733714-3 2013 We describe here a case of acute toxicity associated with recreational use of legal high (6-APB) and cannabis, in which the comprehensive toxicological analysis confirmed the presence of a significant amount of 6-APB together with metabolites of both tetrahydrocannabinol and the synthetic cannabinoid receptor agonist (JWH-122). (4-methyl-1-naphthyl)-(1-pentylindol-3-yl)methanone 320-327 arginyl aminopeptidase Homo sapiens 213-216 23040501-0 2012 Inhibition of the human epithelial calcium channel TRPV6 by 2-aminoethoxydiphenyl borate (2-APB). 2-aminoethoxydiphenyl borate 60-88 arginyl aminopeptidase Homo sapiens 92-95 23668206-1 2013 OBJECTIVE: To study the clinical significance of abnormal protein bands (APB) in multiple myeloma (MM) patients treated with bortezomib-based induction regimen and autologous stem cell transplantation (ASCT). Bortezomib 125-135 arginyl aminopeptidase Homo sapiens 73-76 23668206-7 2013 Patients who developed APB compared with those without APB, had a significantly higher CR plus very good partial response (VGPR) rates (100.0% vs 85.7%%, P=0.017) and CR rates (87.9% vs 62.9%) (P=0.03). Chromium 87-89 arginyl aminopeptidase Homo sapiens 23-26 23668206-11 2013 CONCLUSIONS: Patients who developed APB had a significantly better response to bortezomib-based induction regimen followed ASCT. Bortezomib 79-89 arginyl aminopeptidase Homo sapiens 36-39 23602525-0 2013 Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport. 2-aminoethyl diphenylborinate 69-98 arginyl aminopeptidase Homo sapiens 102-105 23602525-1 2013 2-Aminoethyl diphenylborinate (2-APB) is a known modulator of the IP3 receptor, the calcium ATPase SERCA, the calcium release-activated calcium channel Orai and TRP channels. 2-aminoethyl diphenylborinate 0-29 arginyl aminopeptidase Homo sapiens 33-36 23040501-9 2012 However, N-methyl-d-glucamine significantly diminished the inhibitory effect of 2-APB presumably through direct interaction with this compound. Meglumine 9-29 arginyl aminopeptidase Homo sapiens 82-85 22922232-0 2012 2-aminoethyl diphenyl borinate (2-APB) inhibits TRPM7 channels through an intracellular acidification mechanism. 2-aminoethyl diphenylborinate 0-30 arginyl aminopeptidase Homo sapiens 34-37 22646516-1 2012 BACKGROUND AND PURPOSE: Fenamate analogues, econazole and 2-aminoethoxydiphenyl borate (2-APB) are inhibitors of transient receptor potential melastatin 2 (TRPM2) channels and are used as research tools. Fenamates 24-32 arginyl aminopeptidase Homo sapiens 90-93 22646516-1 2012 BACKGROUND AND PURPOSE: Fenamate analogues, econazole and 2-aminoethoxydiphenyl borate (2-APB) are inhibitors of transient receptor potential melastatin 2 (TRPM2) channels and are used as research tools. 2-aminoethoxydiphenyl borate 58-86 arginyl aminopeptidase Homo sapiens 90-93 22922232-4 2012 Using patch clamp electrophysiology we find that in Jurkat T lymphocytes, 100-300 microM extracellular 2-APB reversibly inhibits TRPM7 channels when internal HEPES concentration is low (1 mM). HEPES 158-163 arginyl aminopeptidase Homo sapiens 105-108 22796571-6 2012 Both bis(2-hydroxy-3-tert-butyl-5-methyl-phenyl)methane(bis-phenol) and 2-aminoethoxydiphenylborate (2-APB) selectively inhibited SPCA1d (with IC(50) values of 0.13 muM and 0.18 mM, respectively), which were of 62- and 8.3-fold greater potency than the values for hSERCA2b (IC(50) values; 8.1 muM and 1.5mM, respectively). bisphenol A 56-66 arginyl aminopeptidase Homo sapiens 103-106 22796571-6 2012 Both bis(2-hydroxy-3-tert-butyl-5-methyl-phenyl)methane(bis-phenol) and 2-aminoethoxydiphenylborate (2-APB) selectively inhibited SPCA1d (with IC(50) values of 0.13 muM and 0.18 mM, respectively), which were of 62- and 8.3-fold greater potency than the values for hSERCA2b (IC(50) values; 8.1 muM and 1.5mM, respectively). 2-aminoethoxydiphenyl borate 72-99 arginyl aminopeptidase Homo sapiens 103-106 21924350-7 2012 Furthermore, EGF-mediated COX-2 activation was prevented by 2-aminoethoxydiphenyl borate (2-APB), a store-operated Ca(2+) channel inhibitor. 2-aminoethoxydiphenyl borate 60-88 arginyl aminopeptidase Homo sapiens 92-95 22472531-3 2012 A 600-800 nm thick glucose-responsive poly(acrylamide-co-3-acrylamidophenylboronic acid) (poly(acrylamide-co-3-APB)) film was polymerised on the quartz disc (12 mm in diameter and 0.25 mm thick) of the MARS. Glucose 21-28 arginyl aminopeptidase Homo sapiens 113-116 22472531-3 2012 A 600-800 nm thick glucose-responsive poly(acrylamide-co-3-acrylamidophenylboronic acid) (poly(acrylamide-co-3-APB)) film was polymerised on the quartz disc (12 mm in diameter and 0.25 mm thick) of the MARS. poly(acrylamide-co-3-acrylamidophenylboronic acid) 40-90 arginyl aminopeptidase Homo sapiens 113-116 22472531-5 2012 A linear relationship between the response of the MARS and the glucose concentration in the range 0-15 mM was observed, with the optimum response of the MARS sensor being obtained when the polymer films contained 20 mol% 3-APB. Glucose 63-70 arginyl aminopeptidase Homo sapiens 227-230 22472531-5 2012 A linear relationship between the response of the MARS and the glucose concentration in the range 0-15 mM was observed, with the optimum response of the MARS sensor being obtained when the polymer films contained 20 mol% 3-APB. Polymers 191-198 arginyl aminopeptidase Homo sapiens 227-230 22607572-10 2012 (iii) When the inositol triphosphate receptor (IP3R) calcium channel was blocked by 2-aminoethoxydiphenyl-borinate (2-APB), caspase-9 was completely inhibited, GRP78 and caspase-4 increased dramatically, and caspase-3 expression was not affected. 2-aminoethoxydiphenyl-borinate 84-114 arginyl aminopeptidase Homo sapiens 118-121 22369768-5 2012 2-APB (10-1000 muM) also inhibited responses to GABA at all concentrations used with an IC(50) value of 16.7 +- 5.4 muM (n=3-5) but had no significant effect on the activation, desensitisation or deactivation kinetics of the GABA responses. gamma-Aminobutyric Acid 48-52 arginyl aminopeptidase Homo sapiens 2-5 22119170-6 2012 2-aminoethoxydiphenyl borate (2-APB), the proved efficient antagonist of SOCs, dose-dependently suppressed the ethanol (200nM)-increased [Ca(2+)](i) content and protected against ethanol-induced viability loss and transaminase leakage. 2-aminoethoxydiphenyl borate 0-28 arginyl aminopeptidase Homo sapiens 32-35 22119170-6 2012 2-aminoethoxydiphenyl borate (2-APB), the proved efficient antagonist of SOCs, dose-dependently suppressed the ethanol (200nM)-increased [Ca(2+)](i) content and protected against ethanol-induced viability loss and transaminase leakage. Ethanol 111-118 arginyl aminopeptidase Homo sapiens 32-35 22119170-6 2012 2-aminoethoxydiphenyl borate (2-APB), the proved efficient antagonist of SOCs, dose-dependently suppressed the ethanol (200nM)-increased [Ca(2+)](i) content and protected against ethanol-induced viability loss and transaminase leakage. Ethanol 179-186 arginyl aminopeptidase Homo sapiens 32-35 21945734-10 2011 RESULTS: CRAC blockers, such as SKF-96365 (1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl) propoxy]ethyl-1H-imidazole), 2-aminoethoxydiphenyl borate (2-APB) and Diethylstilbestrol (DES), inhibited cell proliferations and SOCE in GBM cells. 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole 32-41 arginyl aminopeptidase Homo sapiens 150-153 21193399-2 2011 Recent studies indicate that the Orai3 subtype, in addition to being store-operated, is also activated in a store-independent manner by 2-aminoethyldiphenyl borate (2-APB), a small molecule with complex pharmacology. 2-aminoethyldiphenyl borate 136-163 arginyl aminopeptidase Homo sapiens 167-170 21237246-1 2011 Aminopeptidase B (Ap-B) catalyzes the cleavage of arginine and lysine residues at the N-terminus of various peptide substrates. Arginine 50-58 arginyl aminopeptidase Homo sapiens 0-16 21237246-1 2011 Aminopeptidase B (Ap-B) catalyzes the cleavage of arginine and lysine residues at the N-terminus of various peptide substrates. Arginine 50-58 arginyl aminopeptidase Homo sapiens 18-22 21237246-1 2011 Aminopeptidase B (Ap-B) catalyzes the cleavage of arginine and lysine residues at the N-terminus of various peptide substrates. Lysine 63-69 arginyl aminopeptidase Homo sapiens 0-16 21237246-1 2011 Aminopeptidase B (Ap-B) catalyzes the cleavage of arginine and lysine residues at the N-terminus of various peptide substrates. Lysine 63-69 arginyl aminopeptidase Homo sapiens 18-22 21237246-3 2011 Ap-B is a member of the M1 family of Zn(2+)-metallopeptidases that are characterized by two highly conserved motives, GXMEN (potential substrate binding site) and HEXXHX(18)E (Zn(2+)-binding site). Zinc 37-43 arginyl aminopeptidase Homo sapiens 0-4 21237246-7 2011 The S(328)A mutant mimics the sequence of bovine Ap-B Zn(2+)-binding site, which differs from those of other mammalian Ap-B. Zinc 54-60 arginyl aminopeptidase Homo sapiens 119-123 21987805-7 2011 Interestingly, a dimeric Orai3 stoichiometry was found both before and during application of 2-aminoethyldiphenyl borate (2-APB) to activate a nonselective cation conductance in its STIM1-independent mode. 2-aminoethyldiphenyl borate 93-120 arginyl aminopeptidase Homo sapiens 124-127 21865174-7 2011 G183A mutant channels also exhibited substantial outward currents but were active only in the presence of 2-aminoethoxydiphenyl borate (2-APB), irrespective of STIM1. 2-aminoethoxydiphenyl borate 106-134 arginyl aminopeptidase Homo sapiens 138-141 21483779-8 2011 Finally, the presence of an IP3-releasable Ca(2+) pool in hiPSC-CMs and its contribution to whole-cell [Ca(2+)](i) transients was demonstrated by the inhibitory effects induced by the IP3-receptor blocker 2-Aminoethoxydiphenyl borate (2-APB) and the phospholipase C inhibitor U73122. Inositol 1,4,5-Trisphosphate 28-31 arginyl aminopeptidase Homo sapiens 237-240 21044960-1 2010 The vanilloid transient receptor potential channel TRPV1 is a tetrameric six-transmembrane segment (S1-S6) channel that can be synergistically activated by various proalgesic agents such as capsaicin, protons, heat, or highly depolarizing voltages, and also by 2-aminoethoxydiphenyl borate (2-APB), a common activator of the related thermally gated vanilloid TRP channels TRPV1, TRPV2, and TRPV3. Capsaicin 190-199 arginyl aminopeptidase Homo sapiens 293-296 21266088-8 2011 Indeed, a 2-APB analogue where the boron-oxygen core is replaced by a carbon-phosphorus core is devoid of potentiating capacity (while retaining inhibition capacity), highlighting the key role of the boron-oxygen core present in borinate esters for the potentiation function. Oxygen 206-212 arginyl aminopeptidase Homo sapiens 12-15 21266088-8 2011 Indeed, a 2-APB analogue where the boron-oxygen core is replaced by a carbon-phosphorus core is devoid of potentiating capacity (while retaining inhibition capacity), highlighting the key role of the boron-oxygen core present in borinate esters for the potentiation function. borinate esters 229-244 arginyl aminopeptidase Homo sapiens 12-15 21266088-9 2011 However, dimesityl borinate ester, a 2-APB analogue with a terminal B-OH group showed an efficient inhibitory ability, without any potentiating capacity. dimesityl borinate ester 9-33 arginyl aminopeptidase Homo sapiens 39-42 21266088-12 2011 CONCLUSIONS: This study allows the discovery of new boron-oxygen core containing compounds with the same ability as 2-APB to both potentiate and inhibit the SOCE of different leukocyte cell lines. Boron 52-57 arginyl aminopeptidase Homo sapiens 118-121 21266088-12 2011 CONCLUSIONS: This study allows the discovery of new boron-oxygen core containing compounds with the same ability as 2-APB to both potentiate and inhibit the SOCE of different leukocyte cell lines. Oxygen 58-64 arginyl aminopeptidase Homo sapiens 118-121 21266088-5 2011 To identify novel SOCE effectors, we analyzed the effects of 2-aminoethyl diphenylborinate (2-APB) and its analogues. 2-aminoethyl diphenylborinate 61-90 arginyl aminopeptidase Homo sapiens 94-97 21266088-7 2011 RESULTS: A structure-function analysis allowed to discover that the boron-oxygen core present in 2-APB and in the borinate ester analogues is absolutely required for the dual effects on SOCE. Boron 68-73 arginyl aminopeptidase Homo sapiens 99-102 21266088-7 2011 RESULTS: A structure-function analysis allowed to discover that the boron-oxygen core present in 2-APB and in the borinate ester analogues is absolutely required for the dual effects on SOCE. Oxygen 74-80 arginyl aminopeptidase Homo sapiens 99-102 21266088-8 2011 Indeed, a 2-APB analogue where the boron-oxygen core is replaced by a carbon-phosphorus core is devoid of potentiating capacity (while retaining inhibition capacity), highlighting the key role of the boron-oxygen core present in borinate esters for the potentiation function. Boron 35-40 arginyl aminopeptidase Homo sapiens 12-15 21266088-8 2011 Indeed, a 2-APB analogue where the boron-oxygen core is replaced by a carbon-phosphorus core is devoid of potentiating capacity (while retaining inhibition capacity), highlighting the key role of the boron-oxygen core present in borinate esters for the potentiation function. Oxygen 41-47 arginyl aminopeptidase Homo sapiens 12-15 21266088-8 2011 Indeed, a 2-APB analogue where the boron-oxygen core is replaced by a carbon-phosphorus core is devoid of potentiating capacity (while retaining inhibition capacity), highlighting the key role of the boron-oxygen core present in borinate esters for the potentiation function. Carbon 70-76 arginyl aminopeptidase Homo sapiens 12-15 21266088-8 2011 Indeed, a 2-APB analogue where the boron-oxygen core is replaced by a carbon-phosphorus core is devoid of potentiating capacity (while retaining inhibition capacity), highlighting the key role of the boron-oxygen core present in borinate esters for the potentiation function. Phosphorus 77-87 arginyl aminopeptidase Homo sapiens 12-15 21266088-8 2011 Indeed, a 2-APB analogue where the boron-oxygen core is replaced by a carbon-phosphorus core is devoid of potentiating capacity (while retaining inhibition capacity), highlighting the key role of the boron-oxygen core present in borinate esters for the potentiation function. Boron 200-205 arginyl aminopeptidase Homo sapiens 12-15 21044960-1 2010 The vanilloid transient receptor potential channel TRPV1 is a tetrameric six-transmembrane segment (S1-S6) channel that can be synergistically activated by various proalgesic agents such as capsaicin, protons, heat, or highly depolarizing voltages, and also by 2-aminoethoxydiphenyl borate (2-APB), a common activator of the related thermally gated vanilloid TRP channels TRPV1, TRPV2, and TRPV3. 2-aminoethoxydiphenyl borate 261-289 arginyl aminopeptidase Homo sapiens 293-296 20872887-8 2010 This well-established pathway can be partially inhibited by 2-aminoethoxydiphenyl borate (2-APB), a blocker of SOCC. 2-aminoethoxydiphenyl borate 60-88 arginyl aminopeptidase Homo sapiens 92-95 19348797-9 2009 Propofol and 2-aminoethoxydiphenyl borate (2-APB) inhibited swelling in de-energized mitochondria but did not increase calcium retention capacity (CRC). 2-aminoethoxydiphenyl borate 13-41 arginyl aminopeptidase Homo sapiens 45-48 20054148-8 2010 Our study demonstrates that 2-APB/CPZ induces Ca(2+) entry which unlike ATP- or stretch-induced Ca(2+) entry in ATII cells does not activate exocytosis but an opposing endocytotic mechanism. capsazepine 34-37 arginyl aminopeptidase Homo sapiens 30-33 19429774-6 2009 The [Ca(2+)](i) increase was also abolished by pretreatment with 2-aminoethoxydiphenyl borate (2-APB), an inositol 1,4,5-trisphosphate (IP(3)) receptor antagonist. 2-aminoethoxydiphenyl borate 65-93 arginyl aminopeptidase Homo sapiens 97-100 19429774-6 2009 The [Ca(2+)](i) increase was also abolished by pretreatment with 2-aminoethoxydiphenyl borate (2-APB), an inositol 1,4,5-trisphosphate (IP(3)) receptor antagonist. Inositol 1,4,5-Trisphosphate 106-134 arginyl aminopeptidase Homo sapiens 97-100 19781676-7 2010 Finally, LIPUS-dependent osteoblast increase was abolished in the presence of the Ca(2+) chelator (BAPTA), the inositol 1,4,5-trisphosphate receptor antagonist (2-APB), and the selective P2Y(1) receptor antagonist (MRS2179). 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid 99-104 arginyl aminopeptidase Homo sapiens 163-166 19998500-5 2009 Flufenamic acid, a nonselective cation channel blocker, and 2-APB (2-aminoethoxydiphenyl borate) and La(3+), TRPM7 channel blockers, inhibited the slow waves. 2-aminoethoxydiphenyl borate 67-95 arginyl aminopeptidase Homo sapiens 62-65 19515901-4 2009 The inward current was reduced by La(3+), and the outward current was sensitive to 2-aminoethoxydiphenyl borate (2-APB), spermine, La(3+), and flufenamic acid. 2-aminoethoxydiphenyl borate 83-111 arginyl aminopeptidase Homo sapiens 115-118 19736974-1 2009 To elucidate a mechanism of prothrombotic effects of carbon nanotubes (CNTs), we report here that multiwalled CNTs activate blood platelets by inducing extracellular Ca(2+) influx that could be inhibited by calcium channel blockers SKF 96365 and 2-APB. Carbon 53-59 arginyl aminopeptidase Homo sapiens 248-251 19405998-2 2009 METHODS: The formation of 7-amino-methyl coumarin from specific substrates for APN (L-alanine-4-methyl-coumaryl-7-amide, APB (L-arginine-4-methyl-coumaryl-7-amide) and DPPIV (glycyl-L-proline-4-methyl-coumaryl-7-amide) was used to estimate the KM, Vmax and the effect of aminopeptidases inhibitors on the enzymes. 7-amino-methyl coumarin 26-49 arginyl aminopeptidase Homo sapiens 121-124 19405998-2 2009 METHODS: The formation of 7-amino-methyl coumarin from specific substrates for APN (L-alanine-4-methyl-coumaryl-7-amide, APB (L-arginine-4-methyl-coumaryl-7-amide) and DPPIV (glycyl-L-proline-4-methyl-coumaryl-7-amide) was used to estimate the KM, Vmax and the effect of aminopeptidases inhibitors on the enzymes. glycyl-l-proline-4-methyl-coumaryl-7-amide 175-217 arginyl aminopeptidase Homo sapiens 121-124 19100621-0 2009 2-Aminoethoxydiphenyl-borate (2-APB) increases excitability in pyramidal neurons. 2-aminoethoxydiphenyl borate 0-28 arginyl aminopeptidase Homo sapiens 32-35 19100621-3 2009 In this study, we have described the actions of the IP(3)R and store-operated Ca(2+) channel antagonist, 2-aminoethoxydiphenyl-borate (2-APB), on internal Ca(2+) release and plasma membrane excitability in neocortical and hippocampal pyramidal neurons. 2-aminoethoxydiphenyl borate 105-133 arginyl aminopeptidase Homo sapiens 137-140 19100621-4 2009 Specifically, we found that a dose of 2-APB (100 microM) sufficient for attenuating or blocking IP(3)-mediated internal Ca(2+) release also raised pyramidal neuron excitability. Inositol 1,4,5-Trisphosphate 96-101 arginyl aminopeptidase Homo sapiens 40-43 18651663-6 2008 Ionomycin mimicked the effect of Hcys while BAPTA-AM and 2-APB blocked the effect of Hcys on NC attachment. Homocysteine 85-89 arginyl aminopeptidase Homo sapiens 59-62 18957290-7 2008 Interestingly, the effect of caffeine and La(3+) but not nifedipine were diminished in the present of 2-APB. Caffeine 29-37 arginyl aminopeptidase Homo sapiens 104-107 18957290-7 2008 Interestingly, the effect of caffeine and La(3+) but not nifedipine were diminished in the present of 2-APB. lanthanum(3+) 42-48 arginyl aminopeptidase Homo sapiens 104-107 18822346-3 2008 We show that 2-APB (a blocker of store-operated Ca2+ entry) dramatically reduces glutamate-induced cell death in hippocampal organotypic slice cultures and that glutamate-induced toxicity is accompanied by an increase in TRPC1 expression. Glutamic Acid 81-90 arginyl aminopeptidase Homo sapiens 15-18 18822346-3 2008 We show that 2-APB (a blocker of store-operated Ca2+ entry) dramatically reduces glutamate-induced cell death in hippocampal organotypic slice cultures and that glutamate-induced toxicity is accompanied by an increase in TRPC1 expression. Glutamic Acid 161-170 arginyl aminopeptidase Homo sapiens 15-18 18494937-7 2008 2-aminoethoxydiphenyl borate (2-APB) attenuated both [Mg(2+)](i) load and depletion caused under Na(+)- and Ca(2+)-free conditions. 2-aminoethoxydiphenyl borate 0-28 arginyl aminopeptidase Homo sapiens 32-35 18485891-5 2008 2-Aminoethoxydiphenyl borate (2-APB) inhibited all menthol stimulations. 2-aminoethoxydiphenyl borate 0-28 arginyl aminopeptidase Homo sapiens 32-35 18485891-5 2008 2-Aminoethoxydiphenyl borate (2-APB) inhibited all menthol stimulations. Menthol 51-58 arginyl aminopeptidase Homo sapiens 32-35 18494937-7 2008 2-aminoethoxydiphenyl borate (2-APB) attenuated both [Mg(2+)](i) load and depletion caused under Na(+)- and Ca(2+)-free conditions. magnesium ion 54-60 arginyl aminopeptidase Homo sapiens 32-35 17627971-0 2007 2-APB protects against liver ischemia-reperfusion injury by reducing cellular and mitochondrial calcium uptake. Calcium 96-103 arginyl aminopeptidase Homo sapiens 2-5 18494937-0 2008 Na(+)-independent Mg(2+) transport sensitive to 2-aminoethoxydiphenyl borate (2-APB) in vascular smooth muscle cells: involvement of TRPM-like channels. magnesium ion 18-24 arginyl aminopeptidase Homo sapiens 80-83 18494937-0 2008 Na(+)-independent Mg(2+) transport sensitive to 2-aminoethoxydiphenyl borate (2-APB) in vascular smooth muscle cells: involvement of TRPM-like channels. 2-aminoethoxydiphenyl borate 48-76 arginyl aminopeptidase Homo sapiens 80-83 18204483-0 2008 Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). 2-aminoethoxydiphenyl borate 71-99 arginyl aminopeptidase Homo sapiens 103-106 18006838-6 2007 This Ca(2+)-sensing current can be inhibited by Gd(3+), 2-aminoethoxydiphenyl borate (2-APB), or intracellular Mg(2+), consistent with the TRPM7 current being activated. 2-aminoethoxydiphenyl borate 56-84 arginyl aminopeptidase Homo sapiens 88-91 17915188-6 2008 In addition, LPA caused an increase in the intracellular Ca(2+) concentration ([Ca(2+)](i)), which was inhibited by pretreatment with Ki16425 or 2-aminoethoxy-diphenylborate (2-APB), an inositol 1,4,5-triphosphate (IP(3)) receptor (IP(3)R) blocker. lysophosphatidic acid 13-16 arginyl aminopeptidase Homo sapiens 177-180 17915188-6 2008 In addition, LPA caused an increase in the intracellular Ca(2+) concentration ([Ca(2+)](i)), which was inhibited by pretreatment with Ki16425 or 2-aminoethoxy-diphenylborate (2-APB), an inositol 1,4,5-triphosphate (IP(3)) receptor (IP(3)R) blocker. 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid 134-141 arginyl aminopeptidase Homo sapiens 177-180 17915188-7 2008 The pretreatment of SaM-1 cells with U-73122, a phospholipase C (PLC) inhibitor, and 2-APB also inhibited the increase in IL-6 and IL-8 synthesis in response to LPA. lysophosphatidic acid 161-164 arginyl aminopeptidase Homo sapiens 87-90 18335445-2 2008 The incorporation of 3-acrylamide phenyl boronic acid (3-APB) into a hydrogel generates a suitably responsive and fully reversible holographic sensor for L-lactate. 3-acrylamide phenyl boronic acid 21-53 arginyl aminopeptidase Homo sapiens 57-60 18335445-2 2008 The incorporation of 3-acrylamide phenyl boronic acid (3-APB) into a hydrogel generates a suitably responsive and fully reversible holographic sensor for L-lactate. L-lactate 154-163 arginyl aminopeptidase Homo sapiens 57-60 17761776-5 2007 An IP(3)-dependent increase of [Ca(2+)](Nuc) was still observed after pretreatment with tetracaine to block Ca(2+) release from ryanodine receptors (RyRs), and the effect of IP(3) was partially reversed or prevented by the IP(3)R blockers heparin and 2-APB. Inositol 1,4,5-Trisphosphate 3-8 arginyl aminopeptidase Homo sapiens 253-256 17761776-5 2007 An IP(3)-dependent increase of [Ca(2+)](Nuc) was still observed after pretreatment with tetracaine to block Ca(2+) release from ryanodine receptors (RyRs), and the effect of IP(3) was partially reversed or prevented by the IP(3)R blockers heparin and 2-APB. Tetracaine 88-98 arginyl aminopeptidase Homo sapiens 253-256 17627971-3 2007 We have previously defined a novel pathway for mitochondrial Ca(2+) handling and now further characterize this pathway and investigate a novel Ca(2+)-channel inhibitor, 2-aminoethoxydiphenyl borate (2-APB), for preventing hepatic I/R injury. 2-aminoethoxydiphenyl borate 169-197 arginyl aminopeptidase Homo sapiens 201-204 17627971-10 2007 2-APB significantly reduced cellular damage determined by hematoxylin and eosin and terminal deoxynucleotidyl transferase dUTP-mediated nick-end labeling staining of liver tissue. Hematoxylin 58-69 arginyl aminopeptidase Homo sapiens 2-5 17627971-10 2007 2-APB significantly reduced cellular damage determined by hematoxylin and eosin and terminal deoxynucleotidyl transferase dUTP-mediated nick-end labeling staining of liver tissue. Eosine Yellowish-(YS) 74-79 arginyl aminopeptidase Homo sapiens 2-5 17627971-10 2007 2-APB significantly reduced cellular damage determined by hematoxylin and eosin and terminal deoxynucleotidyl transferase dUTP-mediated nick-end labeling staining of liver tissue. deoxyuridine triphosphate 122-126 arginyl aminopeptidase Homo sapiens 2-5 17594756-2 2007 Here, 2-aminoethoxydiphenyl borate (2-APB) is introduced as a novel and effective inhibitor of the HICC in HeLa cells. 2-aminoethoxydiphenyl borate 6-34 arginyl aminopeptidase Homo sapiens 38-41 16366656-1 2005 Aminoethoxydiphenyl borate (2-APB), 1, is a potent inhibitor of store-operated calcium entry channels (SOCCs). aminoethoxydiphenyl borate 0-26 arginyl aminopeptidase Homo sapiens 30-33 17115071-7 2007 The partial inhibitor of both ROCs and SOCs, Mg2+, and the SOC inhibitors, dextromethorphan, SKF-96365 (1-[beta-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenethyl]-1H-imidazole HCL) and 2-APB (2-aminoethoxydiphenyl borate), inhibited PLC activity at low concentrations of orexin-A, but were not as effective as TEA. 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole 93-102 arginyl aminopeptidase Homo sapiens 185-188 17130674-5 2006 2-APB [(2-aminoethoxy)diphenylborane], an inositol 1,4,5-trisphosphate (IP(3))-receptor antagonist, inhibited UTP-induced IL-6 mRNA expression; and the action of A23187, a Ca(2+) ionophore, resembled the action of UTP. 2-aminoethoxydiphenylborane 7-36 arginyl aminopeptidase Homo sapiens 2-5 17130674-5 2006 2-APB [(2-aminoethoxy)diphenylborane], an inositol 1,4,5-trisphosphate (IP(3))-receptor antagonist, inhibited UTP-induced IL-6 mRNA expression; and the action of A23187, a Ca(2+) ionophore, resembled the action of UTP. Inositol 42-50 arginyl aminopeptidase Homo sapiens 2-5 17130674-5 2006 2-APB [(2-aminoethoxy)diphenylborane], an inositol 1,4,5-trisphosphate (IP(3))-receptor antagonist, inhibited UTP-induced IL-6 mRNA expression; and the action of A23187, a Ca(2+) ionophore, resembled the action of UTP. ,4,5-trisphosphate 52-70 arginyl aminopeptidase Homo sapiens 2-5 17130674-5 2006 2-APB [(2-aminoethoxy)diphenylborane], an inositol 1,4,5-trisphosphate (IP(3))-receptor antagonist, inhibited UTP-induced IL-6 mRNA expression; and the action of A23187, a Ca(2+) ionophore, resembled the action of UTP. Uridine Triphosphate 110-113 arginyl aminopeptidase Homo sapiens 2-5 17130674-5 2006 2-APB [(2-aminoethoxy)diphenylborane], an inositol 1,4,5-trisphosphate (IP(3))-receptor antagonist, inhibited UTP-induced IL-6 mRNA expression; and the action of A23187, a Ca(2+) ionophore, resembled the action of UTP. Calcimycin 162-168 arginyl aminopeptidase Homo sapiens 2-5 17130674-5 2006 2-APB [(2-aminoethoxy)diphenylborane], an inositol 1,4,5-trisphosphate (IP(3))-receptor antagonist, inhibited UTP-induced IL-6 mRNA expression; and the action of A23187, a Ca(2+) ionophore, resembled the action of UTP. Uridine Triphosphate 214-217 arginyl aminopeptidase Homo sapiens 2-5 16906615-1 2006 In this study, 2-acrylamidophenylboronate (2-APB) was synthesised and its ability to bind with glucose was investigated both in solution and when integrated into a holographic sensor. 2-acrylamidophenylboronate 15-41 arginyl aminopeptidase Homo sapiens 45-48 16906615-1 2006 In this study, 2-acrylamidophenylboronate (2-APB) was synthesised and its ability to bind with glucose was investigated both in solution and when integrated into a holographic sensor. Glucose 95-102 arginyl aminopeptidase Homo sapiens 45-48 16906615-2 2006 Multiple forms of 2-APB, resulting from the neighbouring effect of the amido group with the boronic acid through an intramolecular B--O-coordinated interaction, were shown to exist in solution by using multinuclear NMR spectrometry. amido 71-76 arginyl aminopeptidase Homo sapiens 20-23 16906615-2 2006 Multiple forms of 2-APB, resulting from the neighbouring effect of the amido group with the boronic acid through an intramolecular B--O-coordinated interaction, were shown to exist in solution by using multinuclear NMR spectrometry. Boronic Acids 92-104 arginyl aminopeptidase Homo sapiens 20-23 16906615-4 2006 The complex formation of 2-APB with glucose and lactate was investigated in DMSO; 2-APB favours binding with glucose rather than lactate and generates a five-membered-ring complex. Glucose 36-43 arginyl aminopeptidase Homo sapiens 27-30 16906615-4 2006 The complex formation of 2-APB with glucose and lactate was investigated in DMSO; 2-APB favours binding with glucose rather than lactate and generates a five-membered-ring complex. Glucose 36-43 arginyl aminopeptidase Homo sapiens 84-87 16906615-4 2006 The complex formation of 2-APB with glucose and lactate was investigated in DMSO; 2-APB favours binding with glucose rather than lactate and generates a five-membered-ring complex. Lactic Acid 48-55 arginyl aminopeptidase Homo sapiens 27-30 16906615-4 2006 The complex formation of 2-APB with glucose and lactate was investigated in DMSO; 2-APB favours binding with glucose rather than lactate and generates a five-membered-ring complex. Lactic Acid 48-55 arginyl aminopeptidase Homo sapiens 84-87 16906615-4 2006 The complex formation of 2-APB with glucose and lactate was investigated in DMSO; 2-APB favours binding with glucose rather than lactate and generates a five-membered-ring complex. Dimethyl Sulfoxide 76-80 arginyl aminopeptidase Homo sapiens 27-30 16906615-4 2006 The complex formation of 2-APB with glucose and lactate was investigated in DMSO; 2-APB favours binding with glucose rather than lactate and generates a five-membered-ring complex. Dimethyl Sulfoxide 76-80 arginyl aminopeptidase Homo sapiens 84-87 16906615-4 2006 The complex formation of 2-APB with glucose and lactate was investigated in DMSO; 2-APB favours binding with glucose rather than lactate and generates a five-membered-ring complex. Glucose 109-116 arginyl aminopeptidase Homo sapiens 27-30 16906615-4 2006 The complex formation of 2-APB with glucose and lactate was investigated in DMSO; 2-APB favours binding with glucose rather than lactate and generates a five-membered-ring complex. Glucose 109-116 arginyl aminopeptidase Homo sapiens 84-87 16906615-4 2006 The complex formation of 2-APB with glucose and lactate was investigated in DMSO; 2-APB favours binding with glucose rather than lactate and generates a five-membered-ring complex. Lactic Acid 129-136 arginyl aminopeptidase Homo sapiens 27-30 16906615-5 2006 Furthermore, a 2-APB-based holographic sensor displayed a significant response to glucose with little interference from lactate, and with no dependence on pH in the physiological pH range. Glucose 82-89 arginyl aminopeptidase Homo sapiens 17-20 16906615-5 2006 Furthermore, a 2-APB-based holographic sensor displayed a significant response to glucose with little interference from lactate, and with no dependence on pH in the physiological pH range. Lactic Acid 120-127 arginyl aminopeptidase Homo sapiens 17-20 16906615-6 2006 These features suggest that the new ligand 2-APB is a potential candidate for the development of glucose-selective sensors. Glucose 97-104 arginyl aminopeptidase Homo sapiens 45-48 16974067-4 2006 The increase that occurred during the administration partially remained in the Ca(2+)-free medium and was blocked by 2-aminoethoxydiphenyl borate (2-APB), an IP(3)-receptor blocker, indicating that the source of Ca(2+) for the increase could be ascribed to the intracellular store. 2-aminoethoxydiphenyl borate 117-145 arginyl aminopeptidase Homo sapiens 149-152 16882691-4 2006 The endothelin-1-mediated spontaneous Ca2+ transients were abolished by application of 2-aminoethoxydiphenyl borate (2-APB), an antagonist of Ins(1,4,5)P3 receptors. 2-aminoethoxydiphenyl borate 87-115 arginyl aminopeptidase Homo sapiens 119-122 16882691-5 2006 Incubation of electrically-paced ventricular myocytes with a membrane-permeant Ins(1,4,5)P3 ester provoked the occurrence of spontaneous diastolic Ca2+ transients with the same characteristics and sensitivity to 2-APB as the events stimulated by endothelin-1. ins(1,4,5)p3 ester 79-97 arginyl aminopeptidase Homo sapiens 214-217 16765942-2 2006 We used the transient receptor potential channel (TRP) blocker, 2-aminoethoxydiphenyl borate (2-APB), to test the hypothesis that KCl activates additional Ca(2+) entry pathways. 2-aminoethoxydiphenyl borate 64-92 arginyl aminopeptidase Homo sapiens 96-99 16765942-3 2006 2-APB alone caused a transient weak increase in force, a sustained weak increase in basal [Ca(2+)](i) and myosin light chain phosphorylation, and inhibition of KCl-induced force, [Ca(2+)](i) and myosin light chain phosphorylation. Potassium Chloride 160-163 arginyl aminopeptidase Homo sapiens 2-5 16381797-5 2006 Inhibitors of IP(3)-dependent Ca(2+) signals, like 2-aminoethoxydiphenyl borate (2-APB) and U-73122, decreased activation of IL-6 gene expression as did Ca(2+) signals inhibitor BAPTA-AM, whereas ryanodine, a fast Ca(2+) transient inhibitor, had no effect on IL-6 induction. Inositol 1,4,5-Trisphosphate 14-19 arginyl aminopeptidase Homo sapiens 83-86 16381797-5 2006 Inhibitors of IP(3)-dependent Ca(2+) signals, like 2-aminoethoxydiphenyl borate (2-APB) and U-73122, decreased activation of IL-6 gene expression as did Ca(2+) signals inhibitor BAPTA-AM, whereas ryanodine, a fast Ca(2+) transient inhibitor, had no effect on IL-6 induction. 2-aminoethoxydiphenyl borate 51-79 arginyl aminopeptidase Homo sapiens 83-86 16636202-7 2006 Moreover, micromolar levels of 2-aminoethoxydiphenyl borate (2-APB) maximally increase TRPM6 but significantly inhibit TRPM7 channel activities; whereas millimolar concentrations of 2-APB potentiate TRPM6/7 and TRPM7 channel activities. 2-aminoethoxydiphenyl borate 31-59 arginyl aminopeptidase Homo sapiens 63-66 16636202-8 2006 Furthermore, Mg2+ and Ca2+ entry through TRPM6 is enhanced three- to fourfold by 2-APB. magnesium ion 13-17 arginyl aminopeptidase Homo sapiens 83-86 17395593-2 2007 However, TRPV2 responses to heat as well as to the nonselective agonist 2-aminoethoxydiphenyl borate (2-APB) have not been universally reproduced in other laboratories, leading to debate about the activation properties of this channel. 2-aminoethoxydiphenyl borate 72-100 arginyl aminopeptidase Homo sapiens 104-107 17095584-1 2007 2-aminoethoxydiphenyl borate (2-APB), a commonly used blocker of IP3-induced calcium ion release and of store-operated channels, inhibits gap junction conductance when applied to cultured cells. 2-aminoethoxydiphenyl borate 0-28 arginyl aminopeptidase Homo sapiens 32-35 17095584-1 2007 2-aminoethoxydiphenyl borate (2-APB), a commonly used blocker of IP3-induced calcium ion release and of store-operated channels, inhibits gap junction conductance when applied to cultured cells. Inositol 1,4,5-Trisphosphate 65-68 arginyl aminopeptidase Homo sapiens 32-35 17095584-1 2007 2-aminoethoxydiphenyl borate (2-APB), a commonly used blocker of IP3-induced calcium ion release and of store-operated channels, inhibits gap junction conductance when applied to cultured cells. Calcium 77-84 arginyl aminopeptidase Homo sapiens 32-35 16847098-9 2006 The exposure with SR Ca(2+) channel inhibitors (ryanodine and 2-APB) and phospholipase C inhibitor (U73122) significantly reduced RSD in both cell types but with a stronger effect in dystrophin-deficient SolC1(-) myotubes. RSD 130-133 arginyl aminopeptidase Homo sapiens 64-67 16960410-5 2006 In the increase groups, premature beats tended to increase in proportion to changes in THBs with age (APB: Y = 207.488 + 0.136 X, r = 0.848, P = 0.0303; VPB: Y = -27.594 + 0.028 X, r = 0.727, P = 0.1921). thbs 87-91 arginyl aminopeptidase Homo sapiens 102-105 16595904-1 2006 Bestatin is an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B. ubenimex 0-8 arginyl aminopeptidase Homo sapiens 60-76 16446505-3 2006 The analysis of amplitude and kinetics of the calcium increase in SolC1(-) and in SolD(+) myotubes during the exposure with SR Ca2+ channel inhibitors (ryanodine and 2-APB) suggested the presence of two mechanisms of SR calcium release: (1) a fast SR calcium release that depended on ryanodine receptors and (2) a slow SR calcium release mediated by IP3 receptors. Calcium 46-53 arginyl aminopeptidase Homo sapiens 168-171 16446505-3 2006 The analysis of amplitude and kinetics of the calcium increase in SolC1(-) and in SolD(+) myotubes during the exposure with SR Ca2+ channel inhibitors (ryanodine and 2-APB) suggested the presence of two mechanisms of SR calcium release: (1) a fast SR calcium release that depended on ryanodine receptors and (2) a slow SR calcium release mediated by IP3 receptors. Calcium 220-227 arginyl aminopeptidase Homo sapiens 168-171 16446505-3 2006 The analysis of amplitude and kinetics of the calcium increase in SolC1(-) and in SolD(+) myotubes during the exposure with SR Ca2+ channel inhibitors (ryanodine and 2-APB) suggested the presence of two mechanisms of SR calcium release: (1) a fast SR calcium release that depended on ryanodine receptors and (2) a slow SR calcium release mediated by IP3 receptors. Calcium 220-227 arginyl aminopeptidase Homo sapiens 168-171 16446505-3 2006 The analysis of amplitude and kinetics of the calcium increase in SolC1(-) and in SolD(+) myotubes during the exposure with SR Ca2+ channel inhibitors (ryanodine and 2-APB) suggested the presence of two mechanisms of SR calcium release: (1) a fast SR calcium release that depended on ryanodine receptors and (2) a slow SR calcium release mediated by IP3 receptors. Calcium 220-227 arginyl aminopeptidase Homo sapiens 168-171 16446505-6 2006 Upon incubation with pertussis toxin (PTX), an inhibitory effect similar to that of the IP3R inhibitor (2-APB) was observed on K+-evoked calcium release. Calcium 137-144 arginyl aminopeptidase Homo sapiens 106-109 16493832-1 2006 A solid source of "active" oxygen (acetylperoxyborate, APB), when dissolved in aqueous solution in the presence of a single-site microporous catalyst containing redox centres (Fe(III)AlPO-31, Mn(III)AlPO-5, Fe(III)AlPO-5), converts cyclohexane with high efficiency (ca. Oxygen 27-33 arginyl aminopeptidase Homo sapiens 55-58 16299551-6 2006 U73122 (phospholipase C inhibitor) and 2-APB (IP3 antagonist) were effective in inhibition of GF contraction. Inositol 1,4,5-Trisphosphate 46-49 arginyl aminopeptidase Homo sapiens 41-44 16099040-3 2005 In the absence of L-VOCC blockade, LOE 908 reduced the Ach-response to 49+/-7% (p<0.001, n=8) and SK and F 96365 to 3+/-2% (p<0.001, n=4) of control, whereas 2-APB transiently increased the response (peak effect: 130+/-11%; p<0.05, n=8). 1-[[(3~{S})-1,4-dioxaspiro[4.5]decan-3-yl]methyl]piperidine 35-38 arginyl aminopeptidase Homo sapiens 166-169 15447680-0 2004 Inhibition of glutamate-induced delayed calcium deregulation by 2-APB and La3+ in cultured cortical neurones. Glutamic Acid 14-23 arginyl aminopeptidase Homo sapiens 66-69 15488595-0 2004 The blocking of capacitative calcium entry by 2-aminoethyl diphenylborate (2-APB) and carboxyamidotriazole (CAI) inhibits proliferation in Hep G2 and Huh-7 human hepatoma cells. Calcium 29-36 arginyl aminopeptidase Homo sapiens 77-80 15488595-0 2004 The blocking of capacitative calcium entry by 2-aminoethyl diphenylborate (2-APB) and carboxyamidotriazole (CAI) inhibits proliferation in Hep G2 and Huh-7 human hepatoma cells. 2-aminoethyldiphenylborate 46-73 arginyl aminopeptidase Homo sapiens 77-80 15488595-6 2004 CAI (10 microM) and 2-APB (20 microM) completely blocked CCE in thapsigargin-treated Huh-7, and CAI and 2-APB inhibited cell proliferation with IC50 of 4.5 and 43 microM, respectively. Carbamylcholine 57-60 arginyl aminopeptidase Homo sapiens 22-25 15488595-6 2004 CAI (10 microM) and 2-APB (20 microM) completely blocked CCE in thapsigargin-treated Huh-7, and CAI and 2-APB inhibited cell proliferation with IC50 of 4.5 and 43 microM, respectively. Thapsigargin 64-76 arginyl aminopeptidase Homo sapiens 22-25 15558242-7 2004 This response was slightly attenuated by 2-aminoethyldiphenyl borate (2-APB), a D: -myo-inositol 1,4,5-trisphosphate (IP(3)) receptor blocker, and by genistein, a general tyrosine kinase inhibitor. 2-aminoethyldiphenyl borate 41-68 arginyl aminopeptidase Homo sapiens 72-75 15558242-7 2004 This response was slightly attenuated by 2-aminoethyldiphenyl borate (2-APB), a D: -myo-inositol 1,4,5-trisphosphate (IP(3)) receptor blocker, and by genistein, a general tyrosine kinase inhibitor. Genistein 150-159 arginyl aminopeptidase Homo sapiens 72-75 15447680-0 2004 Inhibition of glutamate-induced delayed calcium deregulation by 2-APB and La3+ in cultured cortical neurones. Calcium 40-47 arginyl aminopeptidase Homo sapiens 66-69 15447680-3 2004 Here, we report that the delayed Ca2+ entry in cortical neurones is diminished by 2-aminoethoxydiphenyl borate (2-APB: IC50 = 62 +/- 9 microm) and La3+ (IC50 = 7.2 +/- 3 microm), both known to inhibit transient receptor potential (TRP) and store-operated Ca2+ (SOC) channels. 2-aminoethoxydiphenyl borate 82-110 arginyl aminopeptidase Homo sapiens 114-117 15447680-7 2004 In basal Ca2+ entry experiments, La3+ and 2-APB modulated the rapid rise in [Ca2+]i caused by exposure of neurones to Ca2+ after pre-incubating in a calcium-free medium. Calcium 149-156 arginyl aminopeptidase Homo sapiens 44-47 15447680-9 2004 These results indicate that 2-APB and La3+ influence non-store-operated Ca2+ influx in cortical neurones and that this route of Ca2+ entry is involved in glutamate-induced delayed Ca2+ deregulation. Glutamic Acid 154-163 arginyl aminopeptidase Homo sapiens 30-33 15175387-4 2004 Here, we demonstrate that 2-aminoethoxydiphenyl borate (2-APB), a compound used to inhibit store-operated Ca2+ channels and IP3 receptors, produces robust activation of recombinant TRPV3 in human embryonic kidney 293 cells with an EC50 of 28 microm. 2-aminoethoxydiphenyl borate 26-54 arginyl aminopeptidase Homo sapiens 58-61 15170345-10 2004 To thoroughly understand the importance of this entire region, the work described here investigates the contribution of ApB residues Asn-16, Thr-17, and Ser-19 to toxin affinity and isoform selectivity. Asparagine 133-136 arginyl aminopeptidase Homo sapiens 120-123 15170345-11 2004 Our results demonstrate that residues within and proximal to the C terminus of the Arg-14 loop are important modulators of ApB affinity for Na(V) channels, indicating that the loop and channel site 3 are likely in close contact. Arginine 83-86 arginyl aminopeptidase Homo sapiens 123-126 14563670-8 2004 The phospholipase C inhibitor U-73122 and the SR inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] receptor blocker 2-aminoethoxydiphenyl borate (2-APB) inhibited tone in circular and sling muscles, demonstrating that continuous release of Ca(2+) from Ins(1,4,5)P(3)-sensitive stores is important in tone generation in both muscles. 2-aminoethoxydiphenyl borate 112-140 arginyl aminopeptidase Homo sapiens 144-147 14563670-11 2004 Depletion of SR Ca(2+) stores with CPA or inhibition of Ins(1,4,5)P(3)-mediated store release with either U-73122 or 2-APB inhibited AChC in both muscles. Inositol 1,4,5-Trisphosphate 56-70 arginyl aminopeptidase Homo sapiens 119-122 12153982-0 2002 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release. 2-aminoethoxydiphenyl borate 0-28 arginyl aminopeptidase Homo sapiens 32-35 12767897-0 2003 2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels. 2-aminoethoxydiphenyl borate 0-28 arginyl aminopeptidase Homo sapiens 32-35 12767897-0 2003 2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels. Inositol 1,4,5-Trisphosphate 49-77 arginyl aminopeptidase Homo sapiens 32-35 12767897-0 2003 2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels. Calcium 86-93 arginyl aminopeptidase Homo sapiens 32-35 12767897-1 2003 The action of 2-aminoethoxydiphenyl borate (2-APB) on Ca(2+) signalling in HeLa cells and cardiac myocytes was investigated. 2-aminoethoxydiphenyl borate 14-42 arginyl aminopeptidase Homo sapiens 46-49 12767897-2 2003 Consistent with other studies, we found that superfusion of cells with 2-APB rapidly inhibited inositol 1,4,5-trisphosphate (InsP(3))-mediated Ca(2+) release and store-operated Ca(2+) entry (SOC). Inositol 1,4,5-Trisphosphate 95-123 arginyl aminopeptidase Homo sapiens 73-76 12767897-2 2003 Consistent with other studies, we found that superfusion of cells with 2-APB rapidly inhibited inositol 1,4,5-trisphosphate (InsP(3))-mediated Ca(2+) release and store-operated Ca(2+) entry (SOC). inositol 1,4-bisphosphate 5-phosphorothioate 125-132 arginyl aminopeptidase Homo sapiens 73-76 12767897-3 2003 In addition to abrogating hormone-evoked Ca(2+) responses, 2-APB could antagonise Ca(2+) signals evoked by a membrane permeant InsP(3) ester. insp(3) ester 127-140 arginyl aminopeptidase Homo sapiens 61-64 12767897-8 2003 2-APB did not cause the mitochondria to depolarise, but it reduced the extent of mitochondrial calcium uptake. Calcium 95-102 arginyl aminopeptidase Homo sapiens 2-5 12153564-0 2002 Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB). 2-aminoethoxydiphenyl borate 34-62 arginyl aminopeptidase Homo sapiens 66-69 12153564-1 2002 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites. Adenosine Triphosphate 61-64 arginyl aminopeptidase Homo sapiens 2-5 12153564-2 2002 2-Aminoethoxydiphenyl Borate (2-APB) has been extensively used recently as a membrane permeable modulator of inositol-1,4,5-trisphosphate-sensitive Ca2+ channels and store-operated Ca2+ entry. 2-aminoethoxydiphenyl borate 0-28 arginyl aminopeptidase Homo sapiens 32-35 12153564-3 2002 Here, we report that 2-APB is also an inhibitor of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) Ca2+ pumps, and additionally increases ion leakage across the phospholipid bilayer. Phospholipids 161-173 arginyl aminopeptidase Homo sapiens 23-26 12153564-7 2002 2-APB decreases the affinity for Ca2+ binding to the ATPase by more than 20-fold, and also inhibits phosphoryl transfer from ATP (by 35%), without inhibiting nucleotide binding. Adenosine Triphosphate 53-56 arginyl aminopeptidase Homo sapiens 2-5 14706838-2 2004 In order to study interactions between these two channels, we used 2-aminoethoxydiphenyl borate (2-APB) as a regular SOC inhibitor. 2-aminoethoxydiphenyl borate 67-95 arginyl aminopeptidase Homo sapiens 99-102 14706838-3 2004 Surprisingly 2-APB reduced VRAC activity in a dose-dependent manner (IC(50)=122.8 microM), but not 2,2-diphenyltetrahydrofuran (a structural analog of 2-APB). vrac 27-31 arginyl aminopeptidase Homo sapiens 15-18 12685816-3 2003 For this purpose, 4-methoxy-2-naphthylamide of L-alanine for aminopeptidase N, 4-methoxy-2-naphthylamide of L-leucine for leucine aminopeptidase, 4-methoxy-2-naphthylamide of L-glutamic acid for aminopeptidase A and 4-methoxy-2-naphthylamide of L-arginine for aminopeptidase B were employed. 4-methoxy-2-naphthylamide 18-43 arginyl aminopeptidase Homo sapiens 260-276 12685816-3 2003 For this purpose, 4-methoxy-2-naphthylamide of L-alanine for aminopeptidase N, 4-methoxy-2-naphthylamide of L-leucine for leucine aminopeptidase, 4-methoxy-2-naphthylamide of L-glutamic acid for aminopeptidase A and 4-methoxy-2-naphthylamide of L-arginine for aminopeptidase B were employed. Alanine 47-56 arginyl aminopeptidase Homo sapiens 260-276 12685816-3 2003 For this purpose, 4-methoxy-2-naphthylamide of L-alanine for aminopeptidase N, 4-methoxy-2-naphthylamide of L-leucine for leucine aminopeptidase, 4-methoxy-2-naphthylamide of L-glutamic acid for aminopeptidase A and 4-methoxy-2-naphthylamide of L-arginine for aminopeptidase B were employed. Leucine 108-117 arginyl aminopeptidase Homo sapiens 260-276 12361732-1 2002 A sensitive and selective HPLC-MS-MS method was developed for the determination of trimebutine maleate (TM) and its major metabolites N-monodemethyltrimebutine (TM-MPB), N-didemethyltrimebutine (APB) and 3,4,5-trimethoxybenzoic acid (TMBA) in human plasma. Trimebutine 83-102 arginyl aminopeptidase Homo sapiens 195-198 12361732-1 2002 A sensitive and selective HPLC-MS-MS method was developed for the determination of trimebutine maleate (TM) and its major metabolites N-monodemethyltrimebutine (TM-MPB), N-didemethyltrimebutine (APB) and 3,4,5-trimethoxybenzoic acid (TMBA) in human plasma. Trimebutine 104-106 arginyl aminopeptidase Homo sapiens 195-198 12379177-1 2002 2-Aminoethoxydiphenyl borate (2-APB) is a putative, membrane-permeable inhibitor of inositol 1,4,5-trisphosphate (InsP(3)) receptors, but it is the case that little is known about its action at the InsP(3) receptor level. 2-aminoethoxydiphenyl borate 0-28 arginyl aminopeptidase Homo sapiens 32-35 12379177-1 2002 2-Aminoethoxydiphenyl borate (2-APB) is a putative, membrane-permeable inhibitor of inositol 1,4,5-trisphosphate (InsP(3)) receptors, but it is the case that little is known about its action at the InsP(3) receptor level. Inositol 1,4,5-Trisphosphate 84-112 arginyl aminopeptidase Homo sapiens 32-35 12153982-1 2002 Since its introduction to Ca2+ signaling in 1997, 2-aminoethoxydiphenyl borate (2-APB) has been used in many studies to probe for the involvement of inositol 1,4,5-trisphosphate receptors in the generation of Ca2+ signals. 2-aminoethoxydiphenyl borate 50-78 arginyl aminopeptidase Homo sapiens 82-85 10544041-1 1999 These studies were performed to evaluate the effect of 2-aminoethoxydiphenyl borate (2-APB), a novel membrane-permeable inositol 1,4,5-trisphosphate-receptor inhibitor on agonist-induced, spontaneous, and KCl-stimulated in vitro myometrial contractions. 2-aminoethoxydiphenyl borate 55-83 arginyl aminopeptidase Homo sapiens 87-90 11579153-0 2001 Potentiation and inhibition of Ca(2+) release-activated Ca(2+) channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP(3) receptors. 2-aminoethyldiphenyl borate 75-102 arginyl aminopeptidase Homo sapiens 106-109 11579153-2 2001 The effects of the IP(3)-receptor antagonist 2-aminoethyldiphenyl borate (2-APB) on the Ca(2+) release-activated Ca(2+) current (I(CRAC)) in Jurkat human T cells, DT40 chicken B cells and rat basophilic leukaemia (RBL) cells were examined. 2-aminoethyldiphenyl borate 45-72 arginyl aminopeptidase Homo sapiens 76-79 11918346-9 2001 2-APB had a different inhibitory effect on spontaneous and thapsigargin-induced Ba2+ influx in cells that transiently expressed individual TRP subtypes. Thapsigargin 59-71 arginyl aminopeptidase Homo sapiens 2-5 11918346-9 2001 2-APB had a different inhibitory effect on spontaneous and thapsigargin-induced Ba2+ influx in cells that transiently expressed individual TRP subtypes. N-methyl-valyl-amiclenomycin 80-84 arginyl aminopeptidase Homo sapiens 2-5 11918346-9 2001 2-APB had a different inhibitory effect on spontaneous and thapsigargin-induced Ba2+ influx in cells that transiently expressed individual TRP subtypes. Tryptophan 139-142 arginyl aminopeptidase Homo sapiens 2-5 10639416-5 2000 Of these transformants, only B16B6(Str(r))/tbpA(ap)B(ap) could grow in the presence of porcine transferrin as the sole iron source, achieving a growth rate similar to that of the B16B6 parent strain in the presence of human transferrin. Iron 119-123 arginyl aminopeptidase Homo sapiens 48-52 12119107-1 2002 Aminopeptidase B (APB) is a Zn(2+)-metalloexopeptidase, which selectively removes Arg and/or Lys residues from the N-terminus of several peptide substrates. Arginine 82-85 arginyl aminopeptidase Homo sapiens 0-16 12119107-1 2002 Aminopeptidase B (APB) is a Zn(2+)-metalloexopeptidase, which selectively removes Arg and/or Lys residues from the N-terminus of several peptide substrates. Arginine 82-85 arginyl aminopeptidase Homo sapiens 18-21 12119107-1 2002 Aminopeptidase B (APB) is a Zn(2+)-metalloexopeptidase, which selectively removes Arg and/or Lys residues from the N-terminus of several peptide substrates. Lysine 93-96 arginyl aminopeptidase Homo sapiens 0-16 12119107-1 2002 Aminopeptidase B (APB) is a Zn(2+)-metalloexopeptidase, which selectively removes Arg and/or Lys residues from the N-terminus of several peptide substrates. Lysine 93-96 arginyl aminopeptidase Homo sapiens 18-21 11579153-6 2001 At levels > or = 10 microM, 2-APB caused a transient enhancement of I(CRAC) followed by inhibition. crac 73-77 arginyl aminopeptidase Homo sapiens 33-36 11579153-8 2001 2-APB altered the kinetics of fast Ca(2+)-dependent inactivation of I(CRAC). crac 70-74 arginyl aminopeptidase Homo sapiens 2-5 11579153-14 2001 2-APB inhibited I(CRAC) more potently when applied extracellularly than intracellularly. crac 18-22 arginyl aminopeptidase Homo sapiens 2-5 11579153-24 2001 Potentiation of I(CRAC) by 2-APB may be a useful diagnostic feature for positive identification of putative CRAC channel genes, and provides a novel tool for exploring the physiological functions of store-operated channels. crac 18-22 arginyl aminopeptidase Homo sapiens 29-32 10544041-1 1999 These studies were performed to evaluate the effect of 2-aminoethoxydiphenyl borate (2-APB), a novel membrane-permeable inositol 1,4,5-trisphosphate-receptor inhibitor on agonist-induced, spontaneous, and KCl-stimulated in vitro myometrial contractions. Inositol 120-128 arginyl aminopeptidase Homo sapiens 87-90 10544041-3 1999 Confiriming its effects on intracellular calcium release, 2-APB inhibited phasic contractions in the absence of extracellular calcium. Calcium 41-48 arginyl aminopeptidase Homo sapiens 60-63 8820902-2 1996 The aminopeptidase expressed by the human metastatic HT1080 fibrosarcoma cells was effectively suppressed by actinonin A, bestatin, leuhistin and matlystatin A, which are capable of inhibiting the purified aminopeptidase N, but not by arphamenine B specific for aminopeptidase B. leuhistin 132-141 arginyl aminopeptidase Homo sapiens 262-278 8814645-6 1996 The hydrolysis of lysine-p-nitroanilide, an aminopeptidase B substrate, was also inhibited upon addition of acetaldehyde to Moni-Trol ES serum. lysine-p-nitroanilide 18-39 arginyl aminopeptidase Homo sapiens 44-60 8814645-6 1996 The hydrolysis of lysine-p-nitroanilide, an aminopeptidase B substrate, was also inhibited upon addition of acetaldehyde to Moni-Trol ES serum. Acetaldehyde 108-120 arginyl aminopeptidase Homo sapiens 44-60 8814645-6 1996 The hydrolysis of lysine-p-nitroanilide, an aminopeptidase B substrate, was also inhibited upon addition of acetaldehyde to Moni-Trol ES serum. moni-trol es 124-136 arginyl aminopeptidase Homo sapiens 44-60 10587315-3 1999 For this purpose, (4-aminomethyl)phenylazobenzoic acid (H-AMPB-OH) and (4-amino)phenylazobenzoic acid (H-APB-OH) were synthesized and used to cyclize a bis-cysteinyl-octapeptide giving monocyclic derivatives in which additional conformational restriction could be introduced by conversion to bicyclic structures with a disulphide bridge. (4-amino)phenylazobenzoic acid 71-101 arginyl aminopeptidase Homo sapiens 105-108 10587315-3 1999 For this purpose, (4-aminomethyl)phenylazobenzoic acid (H-AMPB-OH) and (4-amino)phenylazobenzoic acid (H-APB-OH) were synthesized and used to cyclize a bis-cysteinyl-octapeptide giving monocyclic derivatives in which additional conformational restriction could be introduced by conversion to bicyclic structures with a disulphide bridge. bis-cysteinyl-octapeptide 152-177 arginyl aminopeptidase Homo sapiens 105-108 10587315-3 1999 For this purpose, (4-aminomethyl)phenylazobenzoic acid (H-AMPB-OH) and (4-amino)phenylazobenzoic acid (H-APB-OH) were synthesized and used to cyclize a bis-cysteinyl-octapeptide giving monocyclic derivatives in which additional conformational restriction could be introduced by conversion to bicyclic structures with a disulphide bridge. disulphide 319-329 arginyl aminopeptidase Homo sapiens 105-108 9369345-9 1997 The order of potency for these agonists in the presence of phentolamine, propranolol, guanethidine and L-NNA was: 6-bromo-APB > SKF38393 > dopamine > LY171555. Propranolol 73-84 arginyl aminopeptidase Homo sapiens 122-125 9369345-9 1997 The order of potency for these agonists in the presence of phentolamine, propranolol, guanethidine and L-NNA was: 6-bromo-APB > SKF38393 > dopamine > LY171555. Guanethidine 86-98 arginyl aminopeptidase Homo sapiens 122-125 9369345-9 1997 The order of potency for these agonists in the presence of phentolamine, propranolol, guanethidine and L-NNA was: 6-bromo-APB > SKF38393 > dopamine > LY171555. Nitroarginine 103-108 arginyl aminopeptidase Homo sapiens 122-125 9369345-9 1997 The order of potency for these agonists in the presence of phentolamine, propranolol, guanethidine and L-NNA was: 6-bromo-APB > SKF38393 > dopamine > LY171555. Dopamine 145-153 arginyl aminopeptidase Homo sapiens 122-125 9049835-0 1997 Expression and retinoid modulation of N-arginine dibasic convertase and an aminopeptidase-B in human neuroblastoma cell lines. Retinoids 15-23 arginyl aminopeptidase Homo sapiens 75-91 8639500-2 1996 Anthopleurin B (ApB), a toxin produced by the sea anemone Anthopleura xanthogrammica, is the most potent of all known anemone toxins. anthopleurin B 0-14 arginyl aminopeptidase Homo sapiens 16-19 8639500-3 1996 Previous studies in this laboratory have both defined and revealed an important role for the cationic cluster of Arg-12, Arg-14, and Lys-49 in the expression of ApB"s biological activity. Arginine 113-116 arginyl aminopeptidase Homo sapiens 161-164 8639500-3 1996 Previous studies in this laboratory have both defined and revealed an important role for the cationic cluster of Arg-12, Arg-14, and Lys-49 in the expression of ApB"s biological activity. Arginine 121-124 arginyl aminopeptidase Homo sapiens 161-164 8639500-3 1996 Previous studies in this laboratory have both defined and revealed an important role for the cationic cluster of Arg-12, Arg-14, and Lys-49 in the expression of ApB"s biological activity. Lysine 133-136 arginyl aminopeptidase Homo sapiens 161-164 8639500-4 1996 In the present investigation, we explore the role of all remaining charged residues by producing and characterizing mutants of ApB at Asp-7, Asp-9, Lys-37, His-39, and His-34. Aspartic Acid 134-137 arginyl aminopeptidase Homo sapiens 127-130 8639500-4 1996 In the present investigation, we explore the role of all remaining charged residues by producing and characterizing mutants of ApB at Asp-7, Asp-9, Lys-37, His-39, and His-34. Aspartic Acid 141-144 arginyl aminopeptidase Homo sapiens 127-130 8639500-4 1996 In the present investigation, we explore the role of all remaining charged residues by producing and characterizing mutants of ApB at Asp-7, Asp-9, Lys-37, His-39, and His-34. Lysine 148-151 arginyl aminopeptidase Homo sapiens 127-130 8639500-4 1996 In the present investigation, we explore the role of all remaining charged residues by producing and characterizing mutants of ApB at Asp-7, Asp-9, Lys-37, His-39, and His-34. Histidine 156-159 arginyl aminopeptidase Homo sapiens 127-130 8639500-4 1996 In the present investigation, we explore the role of all remaining charged residues by producing and characterizing mutants of ApB at Asp-7, Asp-9, Lys-37, His-39, and His-34. Histidine 168-171 arginyl aminopeptidase Homo sapiens 127-130 7582896-7 1995 The solution structure of the major conformer of AP-B has been determined by two-dimensional 1H NMR at pH 4.5 and 25 degrees C. The core structure is a four-stranded, antiparallel beta-sheet (residues 2-4, 20-23, 34-37 and 45-48) and includes several beta-turns (6-9, 25-28, 30-33). Hydrogen 93-95 arginyl aminopeptidase Homo sapiens 49-53 7612595-3 1995 Previous investigations have suggested an important role for cationic residues in determination of toxin activity, and our single-site mutagenesis studies have indicated that isoform discrimination can be partially explained by the unique cationic residues Arg-12 and Lys-49 of anthopleurin B (ApB). Lysine 268-271 arginyl aminopeptidase Homo sapiens 294-297 8276803-6 1994 In this paper, we describe characterization of three mutants at each of two unique cationic sites of ApB, Arg-12 and Lys-49. Arginine 106-109 arginyl aminopeptidase Homo sapiens 101-104 7559728-8 1995 Bestatin was screened as an inhibitor of aminopeptidase B in 1976. ubenimex 0-8 arginyl aminopeptidase Homo sapiens 41-57 8143849-0 1994 Purification and characterization of a ubenimex (Bestatin)-sensitive aminopeptidase B-like enzyme from K562 human chronic myeloid leukemia cells. ubenimex 39-47 arginyl aminopeptidase Homo sapiens 69-85 7529692-2 1994 DPH increased significantly the motor threshold activation of ADM, APB, FDI and biceps. Phenytoin 0-3 arginyl aminopeptidase Homo sapiens 67-70 1684995-5 1991 From the present work, 3-allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepi ne (6-Br-APB) has been identified as a suitable candidate for further in vivo studies and resolution into its active and inactive enantiomers. 3-allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine 23-98 arginyl aminopeptidase Homo sapiens 105-108 8344358-2 1993 We show in this report that intact Jurkat T cells readily cleaved H-Arg-paranitroanilide, an aminopeptidase B (AP-B) substrate. h-arg-paranitroanilide 66-88 arginyl aminopeptidase Homo sapiens 93-109 8344358-2 1993 We show in this report that intact Jurkat T cells readily cleaved H-Arg-paranitroanilide, an aminopeptidase B (AP-B) substrate. h-arg-paranitroanilide 66-88 arginyl aminopeptidase Homo sapiens 111-115 8344358-3 1993 The identification of the hydrolyzing activity as AP-B was confirmed by its sensitivity to both arphamenine B and bestatin in the nanomolar range. arphamenine B 96-109 arginyl aminopeptidase Homo sapiens 50-54 8344358-3 1993 The identification of the hydrolyzing activity as AP-B was confirmed by its sensitivity to both arphamenine B and bestatin in the nanomolar range. ubenimex 114-122 arginyl aminopeptidase Homo sapiens 50-54 8344358-6 1993 Purified AP-B cleaved N-terminal basic amino acid-containing peptides such as thymopentin (H-Arg-Lys-Asp-Val-Tyr-OH), indicating that it might play a role in the regulation of the concentration of important soluble mediators of T cell activation. Amino Acids, Basic 33-49 arginyl aminopeptidase Homo sapiens 9-13 8344358-6 1993 Purified AP-B cleaved N-terminal basic amino acid-containing peptides such as thymopentin (H-Arg-Lys-Asp-Val-Tyr-OH), indicating that it might play a role in the regulation of the concentration of important soluble mediators of T cell activation. h-arg-lys-asp-val-tyr-oh 91-115 arginyl aminopeptidase Homo sapiens 9-13 8312389-1 1993 An aminopeptidase B from porcine skeletal muscle was successfully purified by ammonium sulphate fractionation and HPLC anion-exchange. Ammonium Sulfate 78-95 arginyl aminopeptidase Homo sapiens 3-19 8312389-2 1993 The purified aminopeptidase B eluted at 0.18 M NaCl, had a relative molecular mass of 76,000 Da and was markedly stimulated in the presence of 0.2 M chloride anion. Sodium Chloride 47-51 arginyl aminopeptidase Homo sapiens 13-29 8312389-2 1993 The purified aminopeptidase B eluted at 0.18 M NaCl, had a relative molecular mass of 76,000 Da and was markedly stimulated in the presence of 0.2 M chloride anion. Chlorides 149-163 arginyl aminopeptidase Homo sapiens 13-29 8312389-4 1993 The enzyme did not show endopeptidase activity and was very stable at pH above 6 and temperatures below 35 degrees C. However, the enzyme inactivated very fast when incubated at pH 5 or at 50-65 degrees C. Bestatin (50 microM) completely inhibited the aminopeptidase B activity while EDTA (5 mM) only inhibited 40% of its activity. ubenimex 206-214 arginyl aminopeptidase Homo sapiens 252-268 8312389-4 1993 The enzyme did not show endopeptidase activity and was very stable at pH above 6 and temperatures below 35 degrees C. However, the enzyme inactivated very fast when incubated at pH 5 or at 50-65 degrees C. Bestatin (50 microM) completely inhibited the aminopeptidase B activity while EDTA (5 mM) only inhibited 40% of its activity. Edetic Acid 284-288 arginyl aminopeptidase Homo sapiens 252-268 1417460-1 1992 (2S,3R)-3,7-Diamino-2-hydroxy-heptanoyl-Leu-Pro-OH [(2S,3R)-DAHHA-Leu-Pro-OH, 4], analogue of the N-terminal tripeptide of probestin, has been synthesized, and tested as inhibitor of AP-B, Leu-AP, AP-M, and enkephalin-degrading APs, and as analgesic. (2s,3r)-3,7-diamino-2-hydroxy-heptanoyl-leu-pro-oh 0-50 arginyl aminopeptidase Homo sapiens 183-187 1417460-1 1992 (2S,3R)-3,7-Diamino-2-hydroxy-heptanoyl-Leu-Pro-OH [(2S,3R)-DAHHA-Leu-Pro-OH, 4], analogue of the N-terminal tripeptide of probestin, has been synthesized, and tested as inhibitor of AP-B, Leu-AP, AP-M, and enkephalin-degrading APs, and as analgesic. (2s,3r)-dahha-leu-pro-oh 52-76 arginyl aminopeptidase Homo sapiens 183-187 1605710-0 1992 Synthesis and inhibitory activities against aminopeptidase B and enkephalin-degrading enzymes of ketomethylene dipeptide analogues of arphamenines. ketomethylene 97-110 arginyl aminopeptidase Homo sapiens 44-60 1605710-0 1992 Synthesis and inhibitory activities against aminopeptidase B and enkephalin-degrading enzymes of ketomethylene dipeptide analogues of arphamenines. Dipeptides 111-120 arginyl aminopeptidase Homo sapiens 44-60 1605710-0 1992 Synthesis and inhibitory activities against aminopeptidase B and enkephalin-degrading enzymes of ketomethylene dipeptide analogues of arphamenines. arphamenines 134-146 arginyl aminopeptidase Homo sapiens 44-60 34136753-5 2021 Moreover, increased RNPEP expression is associated with shorter survival in multiple myeloma patients previously treated with bortezomib-containing regimens. Bortezomib 126-136 arginyl aminopeptidase Homo sapiens 20-25 1649766-1 1991 The combination of aminophosphonobutyric plus kynurenic acids (APB/Kyn) was compared to aspartate with respect to its ability to block synaptic transmission from photoreceptors. Kynurenic Acid 46-61 arginyl aminopeptidase Homo sapiens 63-66 1649766-2 1991 Like aspartate, APB/Kyn blocks photoreceptor synaptic transmission, as monitored by the b- and d-waves of the electroretinogram, by the proximal negative response and M-wave of the proximal retina, and by the light-evoked increase in extracellular K+ concentration in the inner plexiform layer. Aspartic Acid 5-14 arginyl aminopeptidase Homo sapiens 16-19 1863202-0 1991 Synergistic inhibition of aminopeptidase B by penicillamine or cysteine and metallic salts. Penicillamine 46-59 arginyl aminopeptidase Homo sapiens 26-42 1863202-0 1991 Synergistic inhibition of aminopeptidase B by penicillamine or cysteine and metallic salts. Cysteine 63-71 arginyl aminopeptidase Homo sapiens 26-42 1863202-0 1991 Synergistic inhibition of aminopeptidase B by penicillamine or cysteine and metallic salts. metallic salts 76-90 arginyl aminopeptidase Homo sapiens 26-42 1863202-1 1991 The inhibition of aminopeptidase B by D- and L-penicillamine and D- and L-cysteine is reported. d- and l-penicillamine 38-60 arginyl aminopeptidase Homo sapiens 18-34 1863202-1 1991 The inhibition of aminopeptidase B by D- and L-penicillamine and D- and L-cysteine is reported. d- and l-cysteine 65-82 arginyl aminopeptidase Homo sapiens 18-34 33810334-9 2021 Hydrolysis analysis demonstrated that melflufen is a substrate for aminopeptidases LAP3, LTA4H, RNPEP, and ANPEP. melflufen 38-47 arginyl aminopeptidase Homo sapiens 96-101 1786199-6 1991 So it is suggested that one of the possible mechanisms responsible for the direct action of bestatin on the choriocarcinoma cells may be related to the inhibition of activity of LAP or AP-M rather than that of AP-B. ubenimex 92-100 arginyl aminopeptidase Homo sapiens 210-214 34450145-3 2021 The synthesized Fe3O4@CQD@AP-B(OH)2 was characterized by FE-SEM, EDS, XRD, VSM and ICP-OES analysis and its fluorescence property was studied. ferryl iron 16-21 arginyl aminopeptidase Homo sapiens 26-30 34436327-9 2021 The results showed that BCDA-3,4"-ODA/SiO2 MMMs had a larger permeation flux and higher separation factor than BCDA-1,3,3-APB/SiO2 MMMs. 5-bromo-4-chloroindoxyl acetate 111-115 arginyl aminopeptidase Homo sapiens 122-125 34436327-9 2021 The results showed that BCDA-3,4"-ODA/SiO2 MMMs had a larger permeation flux and higher separation factor than BCDA-1,3,3-APB/SiO2 MMMs. Silicon Dioxide 126-130 arginyl aminopeptidase Homo sapiens 122-125 34436327-11 2021 Based on the PSI performance, the optimal SiO2 content was 0.5 wt% for BCDA-3,4"-ODA/SiO2 MMMs and 5 wt% for BCDA-1,3,3-APB/SiO2 MMMs. Silicon Dioxide 42-46 arginyl aminopeptidase Homo sapiens 120-123 34136753-7 2021 We hypothesized that increased aminopeptidase B expression in aggressive myeloma clones may be used therapeutically toward elimination of the cells via the use of a novel peptide-drug conjugate, melphalan flufenamide (melflufen). Melphalan 195-204 arginyl aminopeptidase Homo sapiens 31-47 34136753-7 2021 We hypothesized that increased aminopeptidase B expression in aggressive myeloma clones may be used therapeutically toward elimination of the cells via the use of a novel peptide-drug conjugate, melphalan flufenamide (melflufen). flufenamide 205-216 arginyl aminopeptidase Homo sapiens 31-47 34136753-7 2021 We hypothesized that increased aminopeptidase B expression in aggressive myeloma clones may be used therapeutically toward elimination of the cells via the use of a novel peptide-drug conjugate, melphalan flufenamide (melflufen). melflufen 218-227 arginyl aminopeptidase Homo sapiens 31-47 34136753-8 2021 Melflufen, a substrate of aminopeptidase B, efficiently eliminates bortezomib-resistant myeloma cells in vitro and in vivo, and completely suppresses clonogenic myeloma growth in vitro at subphysiological concentrations. melflufen 0-9 arginyl aminopeptidase Homo sapiens 26-42 34136753-8 2021 Melflufen, a substrate of aminopeptidase B, efficiently eliminates bortezomib-resistant myeloma cells in vitro and in vivo, and completely suppresses clonogenic myeloma growth in vitro at subphysiological concentrations. Bortezomib 67-77 arginyl aminopeptidase Homo sapiens 26-42 34136753-9 2021 Thus, melflufen represents a novel treatment option that is able to eradicate drug-resistant myeloma clones characterized by elevated aminopeptidase B expression. melflufen 6-15 arginyl aminopeptidase Homo sapiens 134-150 2613395-0 1989 Bestatin, an inhibitor of aminopeptidase B, suppresses the proliferation and differentiation of human B-cells in vitro. ubenimex 0-8 arginyl aminopeptidase Homo sapiens 26-42 35093269-0 2022 The APB study: apixaban pharmacokinetics in bariatric patients before to 1 year after vertical sleeve gastrectomy or Roux-en-Y gastric bypass. apixaban 15-23 arginyl aminopeptidase Homo sapiens 4-7 2613395-1 1989 Bestatin, an inhibitor of aminopeptidase B, was examined for its effect on B-cell activation. ubenimex 0-8 arginyl aminopeptidase Homo sapiens 26-42 3680027-3 1987 Compared to ubenimex, p-hydroxyubenimex is more active against aminopeptidase B but less active against leucine aminopeptidase. p-Hydroxyubenimex 22-39 arginyl aminopeptidase Homo sapiens 63-79 3207677-0 1988 Inhibition of arginine aminopeptidase by bestatin and arphamenine analogues. arphamenine 54-65 arginyl aminopeptidase Homo sapiens 14-37 2827067-4 1987 As an example, it is shown that more than 90% of "bound" [3H]aminophosphonobutyrate [( 3H]APB) is displaced by cystine and should be interpreted as APB sequestration. [3h]aminophosphonobutyrate 57-83 arginyl aminopeptidase Homo sapiens 90-93 2827067-4 1987 As an example, it is shown that more than 90% of "bound" [3H]aminophosphonobutyrate [( 3H]APB) is displaced by cystine and should be interpreted as APB sequestration. [3h]aminophosphonobutyrate 57-83 arginyl aminopeptidase Homo sapiens 148-151 2827067-4 1987 As an example, it is shown that more than 90% of "bound" [3H]aminophosphonobutyrate [( 3H]APB) is displaced by cystine and should be interpreted as APB sequestration. Cystine 111-118 arginyl aminopeptidase Homo sapiens 90-93 2827067-4 1987 As an example, it is shown that more than 90% of "bound" [3H]aminophosphonobutyrate [( 3H]APB) is displaced by cystine and should be interpreted as APB sequestration. Cystine 111-118 arginyl aminopeptidase Homo sapiens 148-151 3184126-2 1988 Sulfur-containing amino acid and peptide analogues of bestatin [((2S,3R)-3-amino-2-hydroxy-4-phenyl-butanoyl)-L-leucine] (1) have been synthesized and evaluated as inhibitors of aminopeptidase M (AP-M), leucine aminopeptidase (LAP), and aminopeptidase B (AP-B). Sulfur 0-6 arginyl aminopeptidase Homo sapiens 237-253 3184126-2 1988 Sulfur-containing amino acid and peptide analogues of bestatin [((2S,3R)-3-amino-2-hydroxy-4-phenyl-butanoyl)-L-leucine] (1) have been synthesized and evaluated as inhibitors of aminopeptidase M (AP-M), leucine aminopeptidase (LAP), and aminopeptidase B (AP-B). Sulfur 0-6 arginyl aminopeptidase Homo sapiens 255-259 3184126-3 1988 The 2-thiolbestatin analogue (6) was found to be a potent inhibitor of all three aminopeptidases (AP-M, Ki = 4.4 microM; LAP, Ki = 0.55 microM; AP-B, Ki = 4.6 nM) but only a slightly better inhibitor of these aminopeptidases than the parent hydroxy-containing compound 1. 2-thiolbestatin 4-19 arginyl aminopeptidase Homo sapiens 144-148 3184126-5 1988 A thioamide analogue of bestatin (49) is a modest inhibitor of AP-M (Ki = 40 microM), LAP (Ki = 0.33 microM), and AP-B (Ki = 2.4 microM). Thioamides 2-11 arginyl aminopeptidase Homo sapiens 114-118 3184126-5 1988 A thioamide analogue of bestatin (49) is a modest inhibitor of AP-M (Ki = 40 microM), LAP (Ki = 0.33 microM), and AP-B (Ki = 2.4 microM). ubenimex 24-32 arginyl aminopeptidase Homo sapiens 114-118 3208081-7 1988 Pretreatment with the aminopeptidase B inhibitor, bestatin, increased pressor responses to AIII. ubenimex 50-58 arginyl aminopeptidase Homo sapiens 22-38 3583919-3 1987 OF4949-I and II inhibited aminopeptidase B from Ehrlich ascites carcinoma in a competitive way and the Ki value for both against L-arginine-beta-naphthylamide was 8 X 10(-9) M. Inhibition by I and II of various exopeptidases and endopeptidases was examined. arginine beta-naphthylamide 129-158 arginyl aminopeptidase Homo sapiens 26-42 3111463-0 1987 L-lysinethiol: a subnanomolar inhibitor of aminopeptidase B. l-lysinethiol 0-13 arginyl aminopeptidase Homo sapiens 43-59 3111463-1 1987 L-Lysinethiol was found to be an extremely potent inhibitor of aminopeptidase B (AP-B) with a Ki = 9.1 X 10(-10) M. L-leucinethiol was also a potent inhibitor of AP-B (kj = 1.3 X 10(-7) M), while the D-isomer was much less effective (Ki = 9.8 X 10(-5) M). l-lysinethiol 0-13 arginyl aminopeptidase Homo sapiens 63-79 3111463-1 1987 L-Lysinethiol was found to be an extremely potent inhibitor of aminopeptidase B (AP-B) with a Ki = 9.1 X 10(-10) M. L-leucinethiol was also a potent inhibitor of AP-B (kj = 1.3 X 10(-7) M), while the D-isomer was much less effective (Ki = 9.8 X 10(-5) M). l-lysinethiol 0-13 arginyl aminopeptidase Homo sapiens 81-85 3111463-1 1987 L-Lysinethiol was found to be an extremely potent inhibitor of aminopeptidase B (AP-B) with a Ki = 9.1 X 10(-10) M. L-leucinethiol was also a potent inhibitor of AP-B (kj = 1.3 X 10(-7) M), while the D-isomer was much less effective (Ki = 9.8 X 10(-5) M). l-lysinethiol 0-13 arginyl aminopeptidase Homo sapiens 162-166 3111463-1 1987 L-Lysinethiol was found to be an extremely potent inhibitor of aminopeptidase B (AP-B) with a Ki = 9.1 X 10(-10) M. L-leucinethiol was also a potent inhibitor of AP-B (kj = 1.3 X 10(-7) M), while the D-isomer was much less effective (Ki = 9.8 X 10(-5) M). (S)-2-Amino-4-methyl-pentane-1-thiol 116-130 arginyl aminopeptidase Homo sapiens 63-79 3111463-1 1987 L-Lysinethiol was found to be an extremely potent inhibitor of aminopeptidase B (AP-B) with a Ki = 9.1 X 10(-10) M. L-leucinethiol was also a potent inhibitor of AP-B (kj = 1.3 X 10(-7) M), while the D-isomer was much less effective (Ki = 9.8 X 10(-5) M). (S)-2-Amino-4-methyl-pentane-1-thiol 116-130 arginyl aminopeptidase Homo sapiens 81-85 3111463-1 1987 L-Lysinethiol was found to be an extremely potent inhibitor of aminopeptidase B (AP-B) with a Ki = 9.1 X 10(-10) M. L-leucinethiol was also a potent inhibitor of AP-B (kj = 1.3 X 10(-7) M), while the D-isomer was much less effective (Ki = 9.8 X 10(-5) M). (S)-2-Amino-4-methyl-pentane-1-thiol 116-130 arginyl aminopeptidase Homo sapiens 162-166 3111463-2 1987 A thiol-zinc interaction at the active site is postulated for AP-B. Sulfhydryl Compounds 2-7 arginyl aminopeptidase Homo sapiens 62-66 3748169-3 1986 It has recently become possible to examine the functional role of the ON-pathway in vision by selectively blocking it at the bipolar cell level using the glutamate neurotransmitter analogue 2-amino-4-phosphonobutyrate (APB)1. 2-amino-4-phosphonobutyric acid 190-217 arginyl aminopeptidase Homo sapiens 219-222