PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
18996748-1	2009	Mannose-binding lectin (MBL), a pattern recognition innate immune molecule, selectively binds distinct chemical patterns, including carbohydrates expressed on Group B streptococcus (GBS).	Mannose	0-7	mannose-binding lectin (protein C) 2	Mus musculus	24-27
19193448-3	2009	However, MBL gene deficient mice displayed intact anti-acetylcholine receptor (AChR)-immune response and neuromuscular junction (NMJ) IgG and complement accumulation following AChR-immunization.	Acetylcholine	55-68	mannose-binding lectin (protein C) 2	Mus musculus	9-12
19819031-3	2009	Our study further discovered that infiltration of MBLs into the brain to bind with microglia was detected in the SNc of MPTP-treated mice, suggesting that the BBB compromise and MBL infiltration might be involved in the pathogenesis of MPTP-induced PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	120-124	mannose-binding lectin (protein C) 2	Mus musculus	50-53
19819031-3	2009	Our study further discovered that infiltration of MBLs into the brain to bind with microglia was detected in the SNc of MPTP-treated mice, suggesting that the BBB compromise and MBL infiltration might be involved in the pathogenesis of MPTP-induced PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	236-240	mannose-binding lectin (protein C) 2	Mus musculus	50-53
19819031-5	2009	Intravenous transplantation of MSCs into MPTP-treated mice led to recovery of BBB integrity, suppression of MBL infiltration at SNc and MBL expression in the liver, suppression of microglial activation and prevention of dopaminergic neuron death.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	41-45	mannose-binding lectin (protein C) 2	Mus musculus	108-111
19819031-5	2009	Intravenous transplantation of MSCs into MPTP-treated mice led to recovery of BBB integrity, suppression of MBL infiltration at SNc and MBL expression in the liver, suppression of microglial activation and prevention of dopaminergic neuron death.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	41-45	mannose-binding lectin (protein C) 2	Mus musculus	136-139
19749170-7	2009	These results demonstrate that MI/R-induced complement activation, inflammation, and subsequent tissue injury require both IgM and MBL.	r	34-35	mannose-binding lectin (protein C) 2	Mus musculus	131-134
19684159-2	2009	MBL can bind to sugar determinants of a wide variety of microorganisms, neutralize them and inhibit infection by complement activation through the lectin pathway and opsonization by collectin receptors.	Sugars	16-21	mannose-binding lectin (protein C) 2	Mus musculus	0-3
19684159-4	2009	The carbohydrate recognition domain (CRD) genes of mouse MBL-C (mMBL-C) were cloned and expressed in Escherichia coli.	Carbohydrates	4-16	mannose-binding lectin (protein C) 2	Mus musculus	57-62
19684159-4	2009	The carbohydrate recognition domain (CRD) genes of mouse MBL-C (mMBL-C) were cloned and expressed in Escherichia coli.	Carbohydrates	4-16	mannose-binding lectin (protein C) 2	Mus musculus	64-70
19684159-5	2009	Recombinant mMBL-C-CRD binds to Shigella flexneri 2a in a calcium-dependent manner and that interaction could be blocked by the anti-mMBL-C-CRD antibody.	Calcium	58-65	mannose-binding lectin (protein C) 2	Mus musculus	12-18
19684159-5	2009	Recombinant mMBL-C-CRD binds to Shigella flexneri 2a in a calcium-dependent manner and that interaction could be blocked by the anti-mMBL-C-CRD antibody.	Calcium	58-65	mannose-binding lectin (protein C) 2	Mus musculus	133-139
18996748-1	2009	Mannose-binding lectin (MBL), a pattern recognition innate immune molecule, selectively binds distinct chemical patterns, including carbohydrates expressed on Group B streptococcus (GBS).	Carbohydrates	132-145	mannose-binding lectin (protein C) 2	Mus musculus	24-27
17493687-3	2007	In these studies, we compared carbohydrate-dependent binding of mouse plasma MBL-A and MBL-C to mannan-sepharose beads and to intact bacteria isolated as pathogens from mice.	Sepharose	103-112	mannose-binding lectin (protein C) 2	Mus musculus	87-92
19565324-2	2009	First, a maltose-binding protein fused to DV2 C protein (MBP-C) was overproduced in E. coli.	Maltose	9-16	mannose-binding lectin (protein C) 2	Mus musculus	57-62
19180724-0	2008	The interaction of mannose binding lectin (MBL) with mannose containing glycopeptides and the resultant potential impact on invasive fungal infection.	Mannose	19-26	mannose-binding lectin (protein C) 2	Mus musculus	43-46
19180724-0	2008	The interaction of mannose binding lectin (MBL) with mannose containing glycopeptides and the resultant potential impact on invasive fungal infection.	Mannose	53-60	mannose-binding lectin (protein C) 2	Mus musculus	43-46
19180724-0	2008	The interaction of mannose binding lectin (MBL) with mannose containing glycopeptides and the resultant potential impact on invasive fungal infection.	Glycopeptides	72-85	mannose-binding lectin (protein C) 2	Mus musculus	43-46
19180724-1	2008	Mannnose-binding lectin (MBL) binds oligosaccharides on the surface of microorganisms to form complexes that activate the complement cascade and facilitate phagocytosis.	Oligosaccharides	36-52	mannose-binding lectin (protein C) 2	Mus musculus	0-23
19180724-1	2008	Mannnose-binding lectin (MBL) binds oligosaccharides on the surface of microorganisms to form complexes that activate the complement cascade and facilitate phagocytosis.	Oligosaccharides	36-52	mannose-binding lectin (protein C) 2	Mus musculus	25-28
19180724-2	2008	Teicoplanin and dalbavancin glycopeptide antibiotics possess N-acetyl glucosamine and mannose oligosaccharides that may bind MBL.	Teicoplanin	0-11	mannose-binding lectin (protein C) 2	Mus musculus	125-128
19180724-2	2008	Teicoplanin and dalbavancin glycopeptide antibiotics possess N-acetyl glucosamine and mannose oligosaccharides that may bind MBL.	dalbavancin glycopeptide antibiotics	16-52	mannose-binding lectin (protein C) 2	Mus musculus	125-128
19180724-2	2008	Teicoplanin and dalbavancin glycopeptide antibiotics possess N-acetyl glucosamine and mannose oligosaccharides that may bind MBL.	Acetylglucosamine	61-81	mannose-binding lectin (protein C) 2	Mus musculus	125-128
19180724-2	2008	Teicoplanin and dalbavancin glycopeptide antibiotics possess N-acetyl glucosamine and mannose oligosaccharides that may bind MBL.	mannose oligosaccharides	86-110	mannose-binding lectin (protein C) 2	Mus musculus	125-128
19180724-10	2008	Further, protein polyacrylamide gel electrophoresis studies suggested a potential MBL-drug interaction which may attenuate complement activation, opsonization and phagocytosis.	polyacrylamide	17-31	mannose-binding lectin (protein C) 2	Mus musculus	82-85
18183030-5	2008	In mice subjected to mild CCI (0.2 mm), MBL KO mice had almost two-fold increased acute CA3 cell degeneration at 6 h (P<0.01 versus WT).	CCI	26-29	mannose-binding lectin (protein C) 2	Mus musculus	40-43
17627761-8	2007	Most of the non-synonymous SNPs identified in Mbl1 and Mbl2 occurred in the carbohydrate-recognition domains (CRDs), and some resulted in altered residues close to known ligand binding sites.	Carbohydrates	76-88	mannose-binding lectin (protein C) 2	Mus musculus	55-59
17627761-10	2007	The miscoding SNPs found in the CRD regions of mouse Mbl1, Mbl2, Fcna and Fcnb may be associated with strain differences in glycan binding avidity and disposition of microbial or host ligands.	Polysaccharides	124-130	mannose-binding lectin (protein C) 2	Mus musculus	59-63
18271922-6	2008	However, the overall survival of BL/BLL patients who received cyclophosphamide, doxorubicin, vincristine, and prednisolone-related therapy (22%) was significantly lower than that of DLBCL patients (P = 0.01).	Cyclophosphamide	62-78	mannose-binding lectin (protein C) 2	Mus musculus	33-35
18271922-6	2008	However, the overall survival of BL/BLL patients who received cyclophosphamide, doxorubicin, vincristine, and prednisolone-related therapy (22%) was significantly lower than that of DLBCL patients (P = 0.01).	Doxorubicin	80-91	mannose-binding lectin (protein C) 2	Mus musculus	33-35
18271922-6	2008	However, the overall survival of BL/BLL patients who received cyclophosphamide, doxorubicin, vincristine, and prednisolone-related therapy (22%) was significantly lower than that of DLBCL patients (P = 0.01).	Vincristine	93-104	mannose-binding lectin (protein C) 2	Mus musculus	33-35
18271922-6	2008	However, the overall survival of BL/BLL patients who received cyclophosphamide, doxorubicin, vincristine, and prednisolone-related therapy (22%) was significantly lower than that of DLBCL patients (P = 0.01).	Prednisolone	110-122	mannose-binding lectin (protein C) 2	Mus musculus	33-35
17493687-3	2007	In these studies, we compared carbohydrate-dependent binding of mouse plasma MBL-A and MBL-C to mannan-sepharose beads and to intact bacteria isolated as pathogens from mice.	Carbohydrates	30-42	mannose-binding lectin (protein C) 2	Mus musculus	87-92
17493687-3	2007	In these studies, we compared carbohydrate-dependent binding of mouse plasma MBL-A and MBL-C to mannan-sepharose beads and to intact bacteria isolated as pathogens from mice.	Mannans	96-102	mannose-binding lectin (protein C) 2	Mus musculus	87-92
17493687-4	2007	After incubation of mouse plasma with intact bacteria, MBL-A and MBL-C were eluted with N-acetylglucosamine (GlcNAc) and identified in nonreducing SDS-PAGE using Western blot analysis and MBL-A or MBL-C specific monoclonal antibodies.	Acetylglucosamine	88-107	mannose-binding lectin (protein C) 2	Mus musculus	65-70
17493687-4	2007	After incubation of mouse plasma with intact bacteria, MBL-A and MBL-C were eluted with N-acetylglucosamine (GlcNAc) and identified in nonreducing SDS-PAGE using Western blot analysis and MBL-A or MBL-C specific monoclonal antibodies.	Acetylglucosamine	109-115	mannose-binding lectin (protein C) 2	Mus musculus	65-70
17493687-4	2007	After incubation of mouse plasma with intact bacteria, MBL-A and MBL-C were eluted with N-acetylglucosamine (GlcNAc) and identified in nonreducing SDS-PAGE using Western blot analysis and MBL-A or MBL-C specific monoclonal antibodies.	Sodium Dodecyl Sulfate	147-150	mannose-binding lectin (protein C) 2	Mus musculus	65-70
17493687-5	2007	GlcNAc eluates of plasma incubated with mannan-sepharose beads, Klebsiella oxytoca and Staphylococcus aureus contained similar bands (mainly approximately 50kDa) that were immunoreactive with MBL-C antibody.	Acetylglucosamine	0-6	mannose-binding lectin (protein C) 2	Mus musculus	192-197
17493687-5	2007	GlcNAc eluates of plasma incubated with mannan-sepharose beads, Klebsiella oxytoca and Staphylococcus aureus contained similar bands (mainly approximately 50kDa) that were immunoreactive with MBL-C antibody.	Mannans	40-46	mannose-binding lectin (protein C) 2	Mus musculus	192-197
17892207-3	2007	When MBL or ficolins binds to carbohydrates on the surface of microbes, conformational modifications of these molecules trigger to activate zymogens of MASPs, followed by consequential complement activation.	Carbohydrates	30-43	mannose-binding lectin (protein C) 2	Mus musculus	5-8
17485663-6	2007	In vitro studies have suggested that IgG-G0 antibodies gain the capacity to activate the complement pathway via mannose-binding lectin (MBL), which could contribute to antibody-mediated inflammation.	Mannose	112-119	mannose-binding lectin (protein C) 2	Mus musculus	136-139
17473913-0	2007	Mannose-binding lectin deficiency attenuates renal changes in a streptozotocin-induced model of type 1 diabetes in mice.	Streptozocin	64-78	mannose-binding lectin (protein C) 2	Mus musculus	0-22
17473913-3	2007	MATERIALS AND METHODS: In one group of wild-type mice and in one group of MBL double knockout mice we induced diabetes by the use of streptozotocin as a model of type 1 diabetes.	Streptozocin	133-147	mannose-binding lectin (protein C) 2	Mus musculus	74-77
16375860-3	2006	It inhibited uptake of [methyl-3H]thymidine by MBL2 and PU5 tumor cells but not uptake by S180 and L1210 cells.	[methyl-3h]thymidine	23-43	mannose-binding lectin (protein C) 2	Mus musculus	47-51
16619655-11	2006	The results suggest that the PPT may differentiate among patients better than the GOS, mRS, or mBL The PPT is a valid and reliable instrument for measuring functional status in patients with cerebral aneurysms.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	103-106	mannose-binding lectin (protein C) 2	Mus musculus	95-98
15972690-1	2005	The mannose-binding lectin (MBL), a circulating pattern recognition molecule, recognizes a wide range of infectious agents with resultant initiation of the complement cascade in an Ab-independent manner.	Mannose	4-11	mannose-binding lectin (protein C) 2	Mus musculus	28-31
16299314-4	2005	Complement activation is initiated by the classical, alternative, or lectin pathway, with the latter requiring mannose-binding lectin (MBL, also known as mannose-binding protein).	Mannose	111-118	mannose-binding lectin (protein C) 2	Mus musculus	135-138
16299314-5	2005	MBL is an oligomeric serum protein that recognizes carbohydrates decorating a broad range of infectious agents, including S. aureus.	Carbohydrates	51-64	mannose-binding lectin (protein C) 2	Mus musculus	0-3
15826378-1	2005	Small mannose-binding lectin (MBL)-associated protein (sMAP) is a component of the complex consisting of MBL and MBL-associated serine proteases (MASPs) in the lectin complement pathway.	Mannose	6-13	mannose-binding lectin (protein C) 2	Mus musculus	30-33
15882434-4	2005	Kidney damages, which were evaluated by levels of blood urea nitrogen (BUN) and creatinine, showed that MBL DKO mice were significantly protected compared with WT mice.	Urea	56-60	mannose-binding lectin (protein C) 2	Mus musculus	104-107
15882434-4	2005	Kidney damages, which were evaluated by levels of blood urea nitrogen (BUN) and creatinine, showed that MBL DKO mice were significantly protected compared with WT mice.	Nitrogen	61-69	mannose-binding lectin (protein C) 2	Mus musculus	104-107
15882434-4	2005	Kidney damages, which were evaluated by levels of blood urea nitrogen (BUN) and creatinine, showed that MBL DKO mice were significantly protected compared with WT mice.	Creatinine	80-90	mannose-binding lectin (protein C) 2	Mus musculus	104-107
15826378-1	2005	Small mannose-binding lectin (MBL)-associated protein (sMAP) is a component of the complex consisting of MBL and MBL-associated serine proteases (MASPs) in the lectin complement pathway.	Mannose	6-13	mannose-binding lectin (protein C) 2	Mus musculus	105-108
15826378-1	2005	Small mannose-binding lectin (MBL)-associated protein (sMAP) is a component of the complex consisting of MBL and MBL-associated serine proteases (MASPs) in the lectin complement pathway.	Mannose	6-13	mannose-binding lectin (protein C) 2	Mus musculus	105-108
12847554-2	2003	The first carbohydrate recognition subcomponent of the lectin pathway identified was mannan-binding lectin (MBL), hence the serine proteases were named MBL-associated serine proteases (MASPs) and numbered according to the sequence of their discovery.	Carbohydrates	10-22	mannose-binding lectin (protein C) 2	Mus musculus	85-106
15148336-3	2004	The mannose-binding lectin (MBL, also known as mannose-binding protein) is an oligomeric serum molecule that recognizes carbohydrates decorating a broad range of infectious agents including S. aureus.	Mannose	4-11	mannose-binding lectin (protein C) 2	Mus musculus	28-31
15148336-3	2004	The mannose-binding lectin (MBL, also known as mannose-binding protein) is an oligomeric serum molecule that recognizes carbohydrates decorating a broad range of infectious agents including S. aureus.	Carbohydrates	120-133	mannose-binding lectin (protein C) 2	Mus musculus	28-31
12847554-2	2003	The first carbohydrate recognition subcomponent of the lectin pathway identified was mannan-binding lectin (MBL), hence the serine proteases were named MBL-associated serine proteases (MASPs) and numbered according to the sequence of their discovery.	Carbohydrates	10-22	mannose-binding lectin (protein C) 2	Mus musculus	108-111
12847554-2	2003	The first carbohydrate recognition subcomponent of the lectin pathway identified was mannan-binding lectin (MBL), hence the serine proteases were named MBL-associated serine proteases (MASPs) and numbered according to the sequence of their discovery.	Carbohydrates	10-22	mannose-binding lectin (protein C) 2	Mus musculus	152-155
12471128-5	2002	Western blotting with polyclonal Abs against rat L-MBP demonstrated this protein in Triton X-100 extracts of the small intestine obtained from mice that had undergone systemic perfusion.	Octoxynol	84-96	mannose-binding lectin (protein C) 2	Mus musculus	49-54
12538708-1	2003	Mannose-binding lectin (MBL), a member of the collectin family, binds to carbohydrate structures on the surfaces of micro-organisms and may serve as a recognition molecule of the lectin pathway of complement activation.	Carbohydrates	73-85	mannose-binding lectin (protein C) 2	Mus musculus	0-22
12538708-1	2003	Mannose-binding lectin (MBL), a member of the collectin family, binds to carbohydrate structures on the surfaces of micro-organisms and may serve as a recognition molecule of the lectin pathway of complement activation.	Carbohydrates	73-85	mannose-binding lectin (protein C) 2	Mus musculus	24-27
30366943-5	2019	When introduced into dermis or bleomycin-injured lungs of mice, collectins MBL and SP-D were endocytosed and routed for lysosomal degradation by uPARAP-positive fibroblasts.	Bleomycin	31-40	mannose-binding lectin (protein C) 2	Mus musculus	75-78
12384422-8	2002	Mannose-binding lectin (MBL) complexed with MBL-associated serine proteases (MASPs) bound strongly to LPSs containing MHP and caused C4 activation.	lpss	102-106	mannose-binding lectin (protein C) 2	Mus musculus	0-22
12384422-8	2002	Mannose-binding lectin (MBL) complexed with MBL-associated serine proteases (MASPs) bound strongly to LPSs containing MHP and caused C4 activation.	lpss	102-106	mannose-binding lectin (protein C) 2	Mus musculus	24-27
12384422-8	2002	Mannose-binding lectin (MBL) complexed with MBL-associated serine proteases (MASPs) bound strongly to LPSs containing MHP and caused C4 activation.	lpss	102-106	mannose-binding lectin (protein C) 2	Mus musculus	44-47
12384422-8	2002	Mannose-binding lectin (MBL) complexed with MBL-associated serine proteases (MASPs) bound strongly to LPSs containing MHP and caused C4 activation.	Defensamide	118-121	mannose-binding lectin (protein C) 2	Mus musculus	0-22
12384422-8	2002	Mannose-binding lectin (MBL) complexed with MBL-associated serine proteases (MASPs) bound strongly to LPSs containing MHP and caused C4 activation.	Defensamide	118-121	mannose-binding lectin (protein C) 2	Mus musculus	24-27
12384422-8	2002	Mannose-binding lectin (MBL) complexed with MBL-associated serine proteases (MASPs) bound strongly to LPSs containing MHP and caused C4 activation.	Defensamide	118-121	mannose-binding lectin (protein C) 2	Mus musculus	44-47
11861391-6	2002	Indeed, we found loss of gag(85-93) in RMA, MBL-2, and EL-4G+ lymphoma cells, which share gag(85-93) as an immunodominant CTL epitope, induced to apoptosis by UV irradiation, mitomycin C, doxorubicin, or daunorubicin.	Glycosaminoglycans	25-28	mannose-binding lectin (protein C) 2	Mus musculus	44-49
9343171-5	1997	Late isolates were shown to be much more sensitive than early strains to neutralization by the mouse serum mannose-binding lectin (MBL) and rat lung surfactant protein D (SP-D) and bound greater levels of these lectins in enzyme-linked immunosorbent assays and Western blot analyses.	Mannose	107-114	mannose-binding lectin (protein C) 2	Mus musculus	131-134
7766991-4	1995	The structure of the mouse Mbl genes is similar to that of the rat and human MBP genes and shows homology to the other collectin genes, with the entire carbohydrate recognition domain being encoded in a single exon and all introns being in phase 1.	Carbohydrates	152-164	mannose-binding lectin (protein C) 2	Mus musculus	27-30
11309157-0	2001	Characterization and quantification of mouse mannan-binding lectins (MBL-A and MBL-C) and study of acute phase responses.	Mannans	45-51	mannose-binding lectin (protein C) 2	Mus musculus	79-84
11309157-6	2001	On sucrose density gradient centrifugation the sedimentation velocities of MBL-A and MBL-C were estimated at 7.3 S and 10.8 S, respectively.	Sucrose	3-10	mannose-binding lectin (protein C) 2	Mus musculus	85-90
10679100-5	2000	The two forms of mMBL could be separated both by ion-exchange and carbohydrate-affinity chromatography.	Carbohydrates	66-78	mannose-binding lectin (protein C) 2	Mus musculus	17-21
7894166-0	1994	The murine mannose-binding protein genes (Mbl 1 and Mbl 2) localize to chromosomes 14 and 19.	Mannose	11-18	mannose-binding lectin (protein C) 2	Mus musculus	52-57
1464467-6	1992	Poly(I,C)-LC treatment significantly increased antitumor effector cell functions in a variety of organs (including spleen, lungs, and peritoneum), as shown by increased killing of MBL-2 cells in vitro and increased tumor cell killing by natural killer cells and macrophages.	poly(i,c)-lc	0-12	mannose-binding lectin (protein C) 2	Mus musculus	180-185
34303873-6	2021	The addition of 5b and 5c restored meropenem efficacy against 42 MBL-producing Enterobacterales and Pseudomonas aeruginosa to satisfactory clinical levels.	Meropenem	35-44	mannose-binding lectin (protein C) 2	Mus musculus	65-68
34903857-5	2022	Crystallographic studies revealed a binding mode of the InCs to MBLs that, in some regards, mimics that predicted for intact carbapenems, including with respect to maintenance of the Zn(II)-bound hydroxyl, and in other regards mimics binding observed in MBL-carbapenem product complexes.	Carbapenems	258-268	mannose-binding lectin (protein C) 2	Mus musculus	254-257
34303873-8	2021	Further studies demonstrated that compounds 5b and 5c were non-competitive MBL inhibitors.	5C	51-53	mannose-binding lectin (protein C) 2	Mus musculus	75-78
35381393-9	2022	In the CCl4-induced liver fibrosis model, MBL-/- mice exhibited severer liver fibrosis accompanied by reduced senescent activated HSCs in liver tissue compared with WT mice, which could be inhibited by administrating pAAV-MBL.	Carbon Tetrachloride	7-11	mannose-binding lectin (protein C) 2	Mus musculus	42-45
35347767-8	2022	Additionally, MBL-deficient (MBL-/- ) mice exhibited decreased accumulation of pDC in lymph nodes, spleens, and skin lesions with reduced secretion of pDC-related cytokines compared with wild-type (WT) mice in the preliminary stage of psoriasis induced by imiquimod.	Imiquimod	256-265	mannose-binding lectin (protein C) 2	Mus musculus	29-32
2575605-1	1989	D-(+)-N1-Methyl-2-Br-LSD (MBL), which displays high affinity and selectivity for serotonin receptors in vitro, has been labeled with carbon-11 for localization of cerebral serotonin 5-HT2 receptors by positron emission tomography.	Carbon-11	133-142	mannose-binding lectin (protein C) 2	Mus musculus	26-29
35300210-1	2022	Background: Mannan-binding lectin (MBL) is a key molecule in innate immunity and activates the lectin complement pathway, which plays an important role in resisting Candida albicans (C. albicans) infection.	Mannans	12-18	mannose-binding lectin (protein C) 2	Mus musculus	35-38
2575605-2	1989	[11C]MBL was prepared from [11C]iodomethane and D-(+)-2-Br-LSD within 20 min from end of bombardment.	Carbon-11	1-4	mannose-binding lectin (protein C) 2	Mus musculus	5-8
2575605-2	1989	[11C]MBL was prepared from [11C]iodomethane and D-(+)-2-Br-LSD within 20 min from end of bombardment.	Carbon-11	28-31	mannose-binding lectin (protein C) 2	Mus musculus	5-8
2575605-2	1989	[11C]MBL was prepared from [11C]iodomethane and D-(+)-2-Br-LSD within 20 min from end of bombardment.	methyl iodide	32-43	mannose-binding lectin (protein C) 2	Mus musculus	5-8
2575605-2	1989	[11C]MBL was prepared from [11C]iodomethane and D-(+)-2-Br-LSD within 20 min from end of bombardment.	d-(+)-2-br-lsd	48-62	mannose-binding lectin (protein C) 2	Mus musculus	5-8
2575605-3	1989	The average specific activity of [11C]MBL was 2300 mCi/mumol and the average radiochemical yield was 17%, both at end of synthesis.	Carbon-11	34-37	mannose-binding lectin (protein C) 2	Mus musculus	38-41
2575605-5	1989	administration of [11C]MBL to mice paralleled the known density of serotonin 5-HT2 receptors.	Carbon-11	19-22	mannose-binding lectin (protein C) 2	Mus musculus	23-26
31089880-3	2019	To explain this extracellular ATP is a potent activator of the Nrlp3 inflammasome, which leads to the release of interleukin 1beta and interleukin 18, as well as several danger-associated molecular pattern molecules (DAMPs) that activate the mannan-binding lectin (MBL) pathway of the ComC, from cells of the innate immunity network.	Adenosine Triphosphate	30-33	mannose-binding lectin (protein C) 2	Mus musculus	242-263
6205090-10	1984	Several clones induced a rapid, specific elimination of 131I-labeled MBL-2 tumor cells from the peritoneal cavity after i.v.	Iodine-131	56-60	mannose-binding lectin (protein C) 2	Mus musculus	69-74
1268825-7	1976	Pyran slightly activated macrophages from nonsensitized mice to become cytotoxic for MBL-2 cells; activation was not T-cell dependent.	Pyrans	0-5	mannose-binding lectin (protein C) 2	Mus musculus	85-90
33442785-4	2021	Herein, co-encapsulated pegylated liposomal formulation of mitoxantrone (MIT) and berberine (BER) at an optimal ratio has been developed (MBL) with high encapsulation efficiency (EE) and drug loading in order to achieve the purpose of ratiometric loading and delivery.	Mitoxantrone	59-71	mannose-binding lectin (protein C) 2	Mus musculus	138-141
33442785-4	2021	Herein, co-encapsulated pegylated liposomal formulation of mitoxantrone (MIT) and berberine (BER) at an optimal ratio has been developed (MBL) with high encapsulation efficiency (EE) and drug loading in order to achieve the purpose of ratiometric loading and delivery.	Mitoxantrone	73-76	mannose-binding lectin (protein C) 2	Mus musculus	138-141
33442785-4	2021	Herein, co-encapsulated pegylated liposomal formulation of mitoxantrone (MIT) and berberine (BER) at an optimal ratio has been developed (MBL) with high encapsulation efficiency (EE) and drug loading in order to achieve the purpose of ratiometric loading and delivery.	Berberine	82-91	mannose-binding lectin (protein C) 2	Mus musculus	138-141
33442785-4	2021	Herein, co-encapsulated pegylated liposomal formulation of mitoxantrone (MIT) and berberine (BER) at an optimal ratio has been developed (MBL) with high encapsulation efficiency (EE) and drug loading in order to achieve the purpose of ratiometric loading and delivery.	Berberine	93-96	mannose-binding lectin (protein C) 2	Mus musculus	138-141
32790873-3	2020	OBJECTIVES: To evaluate the activity of carbapenems alone or combined with DMSA against MBL-producing Escherichia coli in a severe murine peritonitis model.	Carbapenems	40-51	mannose-binding lectin (protein C) 2	Mus musculus	88-91
32790873-3	2020	OBJECTIVES: To evaluate the activity of carbapenems alone or combined with DMSA against MBL-producing Escherichia coli in a severe murine peritonitis model.	Succimer	75-79	mannose-binding lectin (protein C) 2	Mus musculus	88-91
32790873-7	2020	Bacterial counts in peritoneal fluid and spleen were assessed at 24 h. RESULTS: DMSA in combination with each carbapenem caused a significant decrease in the MICs for all MBL-producing strains, in a concentration-dependent manner, but did not provide benefit against non-MBL strains.	Succimer	80-84	mannose-binding lectin (protein C) 2	Mus musculus	171-174
32790873-7	2020	Bacterial counts in peritoneal fluid and spleen were assessed at 24 h. RESULTS: DMSA in combination with each carbapenem caused a significant decrease in the MICs for all MBL-producing strains, in a concentration-dependent manner, but did not provide benefit against non-MBL strains.	Succimer	80-84	mannose-binding lectin (protein C) 2	Mus musculus	271-274
32790873-7	2020	Bacterial counts in peritoneal fluid and spleen were assessed at 24 h. RESULTS: DMSA in combination with each carbapenem caused a significant decrease in the MICs for all MBL-producing strains, in a concentration-dependent manner, but did not provide benefit against non-MBL strains.	Carbapenems	110-120	mannose-binding lectin (protein C) 2	Mus musculus	171-174
32790873-7	2020	Bacterial counts in peritoneal fluid and spleen were assessed at 24 h. RESULTS: DMSA in combination with each carbapenem caused a significant decrease in the MICs for all MBL-producing strains, in a concentration-dependent manner, but did not provide benefit against non-MBL strains.	Carbapenems	110-120	mannose-binding lectin (protein C) 2	Mus musculus	271-274
32790873-10	2020	CONCLUSIONS: DMSA restores the activity of carbapenems against MBL-producing strains, and its combination with carbapenems appears to be a promising strategy for the treatment of NDM-producing E. coli infections.	Succimer	13-17	mannose-binding lectin (protein C) 2	Mus musculus	63-66
32790873-10	2020	CONCLUSIONS: DMSA restores the activity of carbapenems against MBL-producing strains, and its combination with carbapenems appears to be a promising strategy for the treatment of NDM-producing E. coli infections.	Carbapenems	43-54	mannose-binding lectin (protein C) 2	Mus musculus	63-66
31930305-4	2020	OBJECTIVES: To evaluate meropenem in vitro activity against MBL-producing Enterobacteriaceae in zinc-depleted broth (Chelex-CAMHB, EDTA-CAMHB) and assess meropenem efficacy in murine infection models.	Meropenem	24-33	mannose-binding lectin (protein C) 2	Mus musculus	60-63
31930305-4	2020	OBJECTIVES: To evaluate meropenem in vitro activity against MBL-producing Enterobacteriaceae in zinc-depleted broth (Chelex-CAMHB, EDTA-CAMHB) and assess meropenem efficacy in murine infection models.	depleted broth	101-115	mannose-binding lectin (protein C) 2	Mus musculus	60-63
31930305-7	2020	RESULTS: All MBL-producing isolates (NDM, n = 25; VIM, n = 3; IMP, n = 2) examined were meropenem resistant in CAMHB and susceptible in zinc-depleted CAMHB (5- to 11-fold reduction), with zinc depletion having no impact on levofloxacin MICs.	Meropenem	88-97	mannose-binding lectin (protein C) 2	Mus musculus	13-16
30967639-1	2020	Mannose-binding lectin (MBL), an initiator of the lectin pathway (LP) of complement activation, is detrimental in ischemic stroke, as shown in clinical studies and rodent models.	leucylproline	66-68	mannose-binding lectin (protein C) 2	Mus musculus	0-22
30967639-1	2020	Mannose-binding lectin (MBL), an initiator of the lectin pathway (LP) of complement activation, is detrimental in ischemic stroke, as shown in clinical studies and rodent models.	leucylproline	66-68	mannose-binding lectin (protein C) 2	Mus musculus	24-27
30967639-7	2020	The induction of Mbl1 and Mbl2 (the MBL-A and MBL-C genes) expression 48 h after tMCAo was similar across genotypes.	tmcao	81-86	mannose-binding lectin (protein C) 2	Mus musculus	26-30
30967639-11	2020	WT and MBL-C-/- ischemic mice had higher LP activity in plasma and, accordingly, higher levels of C3 deposition in the brain than MBL-A-/- and MBL-/- mice.	leucylproline	41-43	mannose-binding lectin (protein C) 2	Mus musculus	7-12
30967639-11	2020	WT and MBL-C-/- ischemic mice had higher LP activity in plasma and, accordingly, higher levels of C3 deposition in the brain than MBL-A-/- and MBL-/- mice.	leucylproline	41-43	mannose-binding lectin (protein C) 2	Mus musculus	7-10
32153567-1	2020	Besides driving lectin pathway (LP) activation, the mannan-binding lectin (MBL)-associated serine proteases (MASPs) also play a key role in regulating the alternative pathway (AP).	Serine	91-97	mannose-binding lectin (protein C) 2	Mus musculus	52-73
32153567-1	2020	Besides driving lectin pathway (LP) activation, the mannan-binding lectin (MBL)-associated serine proteases (MASPs) also play a key role in regulating the alternative pathway (AP).	Serine	91-97	mannose-binding lectin (protein C) 2	Mus musculus	75-78
31591114-3	2019	In the current study, we evaluated the effect of zidebactam on the cefepime pharmacodynamic target time above MIC (T>MIC) exposure required for efficacy against a diverse group of carbapenem-resistant Enterobacteriaceae (CRE) secondary to MBL-production.	Cefepime	67-75	mannose-binding lectin (protein C) 2	Mus musculus	239-242
31260126-4	2019	In this study, we investigated the function of MBL on the course of experimental murine imiquimod (IMQ)-induced psoriasis.	Imiquimod	88-97	mannose-binding lectin (protein C) 2	Mus musculus	47-50
31260126-4	2019	In this study, we investigated the function of MBL on the course of experimental murine imiquimod (IMQ)-induced psoriasis.	Imiquimod	99-102	mannose-binding lectin (protein C) 2	Mus musculus	47-50
31260126-5	2019	Our data showed that MBL-deficient (MBL-/- ) mice exhibited attenuated skin damage characterized by greatly decreased erythema compared with wild-type control mice during the early stages of IMQ-induced psoriasis-like skin inflammation.	Imiquimod	191-194	mannose-binding lectin (protein C) 2	Mus musculus	21-24
3497112-9	1987	In contrast, in vitro sensitization of spleen cells from cured mice with mitomycin-C-treated MBL-2 lymphoma cells resulted in the generation of cytotoxic cells against MBL-2 lymphoma cells.	Mitomycin	73-84	mannose-binding lectin (protein C) 2	Mus musculus	93-98
3497112-9	1987	In contrast, in vitro sensitization of spleen cells from cured mice with mitomycin-C-treated MBL-2 lymphoma cells resulted in the generation of cytotoxic cells against MBL-2 lymphoma cells.	Mitomycin	73-84	mannose-binding lectin (protein C) 2	Mus musculus	168-173
3708572-4	1986	CY increased also the sensitivity of the residual MBL-2 tumor cells to Mo-mediated immunotherapy.	Cyclophosphamide	0-2	mannose-binding lectin (protein C) 2	Mus musculus	50-55
3871661-1	1985	Treatment of normal or MBL-2 tumor-bearing mice with cyclophosphamide (CY) caused severe suppression of myelopoiesis and macrophage (M phi) functions, both of which may limit further use of chemotherapy.	Cyclophosphamide	53-69	mannose-binding lectin (protein C) 2	Mus musculus	23-28
3871661-1	1985	Treatment of normal or MBL-2 tumor-bearing mice with cyclophosphamide (CY) caused severe suppression of myelopoiesis and macrophage (M phi) functions, both of which may limit further use of chemotherapy.	Cyclophosphamide	71-73	mannose-binding lectin (protein C) 2	Mus musculus	23-28
3871661-4	1985	Injection of MBL-2 tumor-bearing mice with MVE-2, at 3 days after Cy treatment, caused a decrease in tumor burden and a significant increase in median survival time as compared to treatment with CY alone.	Cysteine	66-68	mannose-binding lectin (protein C) 2	Mus musculus	13-18
3871661-4	1985	Injection of MBL-2 tumor-bearing mice with MVE-2, at 3 days after Cy treatment, caused a decrease in tumor burden and a significant increase in median survival time as compared to treatment with CY alone.	Cyclophosphamide	195-197	mannose-binding lectin (protein C) 2	Mus musculus	13-18
6605298-0	1983	Expression of H-2 and viral antigens and resistance to the antitumor lysis of tunicamycin-treated MBL-2 lymphoma cells.	Tunicamycin	78-89	mannose-binding lectin (protein C) 2	Mus musculus	98-103
6605298-2	1983	Treatment of the Moloney-virus-induced H-2b lymphoma target cells, MBL-2, with tunicamycin (TM), an inhibitor of the protein-N-linked glycosilation, was found to cause a loss of susceptibility to lysis by MSV-immune syngeneic effectors cells, while the same target cells remained fully sensitive to the lytic action of anti-H-2b-immune lymphocytes.	Tunicamycin	79-90	mannose-binding lectin (protein C) 2	Mus musculus	67-72
33179050-1	2021	BACKGROUND: Using murine models of infection, we previously reported the potent in vivo activity of carbapenems against MBL-producing Enterobacterales despite the observed resistance in vitro.	Carbapenems	100-111	mannose-binding lectin (protein C) 2	Mus musculus	120-123
33179050-8	2021	RESULTS: MBL-producing Enterobacterales strains were found to be cefepime, piperacillin/tazobactam and meropenem non-susceptible in conventional broth.	Cefepime	65-73	mannose-binding lectin (protein C) 2	Mus musculus	9-12
33179050-8	2021	RESULTS: MBL-producing Enterobacterales strains were found to be cefepime, piperacillin/tazobactam and meropenem non-susceptible in conventional broth.	Piperacillin, Tazobactam Drug Combination	75-98	mannose-binding lectin (protein C) 2	Mus musculus	9-12
33179050-8	2021	RESULTS: MBL-producing Enterobacterales strains were found to be cefepime, piperacillin/tazobactam and meropenem non-susceptible in conventional broth.	Meropenem	103-112	mannose-binding lectin (protein C) 2	Mus musculus	9-12
33179050-10	2021	In accordance with the MICs generated in zinc-limited broth, administration of a cefepime human-simulated regimen was associated with substantial bacterial reductions among mice infected with MBL-producing Enterobacterales.	Cefepime	81-89	mannose-binding lectin (protein C) 2	Mus musculus	192-195
32778549-3	2020	ANT2681 is being co-developed with meropenem as the partner beta-lactam as a novel combination therapy for infections caused by MBL-producing bacteria.	ant2681	0-7	mannose-binding lectin (protein C) 2	Mus musculus	128-131
32778549-3	2020	ANT2681 is being co-developed with meropenem as the partner beta-lactam as a novel combination therapy for infections caused by MBL-producing bacteria.	Meropenem	35-44	mannose-binding lectin (protein C) 2	Mus musculus	128-131
32778549-3	2020	ANT2681 is being co-developed with meropenem as the partner beta-lactam as a novel combination therapy for infections caused by MBL-producing bacteria.	beta-Lactams	60-71	mannose-binding lectin (protein C) 2	Mus musculus	128-131
31930305-10	2020	CONCLUSIONS: Results indicate that meropenem in vivo efficacy is best represented by the pharmacodynamic profile generated using MICs determined in zinc-depleted media for MBL-producing Enterobacteriaceae.	Meropenem	35-44	mannose-binding lectin (protein C) 2	Mus musculus	172-175
31578522-9	2019	We also discovered that ligation of mannose-binding lectin (MBL), which binds to glycans of the fungal wall to activate the complement cascade, was required for oncogenic progression, whereas deletion of MBL or C3 in the extratumoral compartment-or knockdown of C3aR in tumour cells-were both protective against tumour growth.	Polysaccharides	81-88	mannose-binding lectin (protein C) 2	Mus musculus	36-58
31578522-9	2019	We also discovered that ligation of mannose-binding lectin (MBL), which binds to glycans of the fungal wall to activate the complement cascade, was required for oncogenic progression, whereas deletion of MBL or C3 in the extratumoral compartment-or knockdown of C3aR in tumour cells-were both protective against tumour growth.	Polysaccharides	81-88	mannose-binding lectin (protein C) 2	Mus musculus	60-63
31089880-3	2019	To explain this extracellular ATP is a potent activator of the Nrlp3 inflammasome, which leads to the release of interleukin 1beta and interleukin 18, as well as several danger-associated molecular pattern molecules (DAMPs) that activate the mannan-binding lectin (MBL) pathway of the ComC, from cells of the innate immunity network.	Adenosine Triphosphate	30-33	mannose-binding lectin (protein C) 2	Mus musculus	265-268
30351498-5	2019	We here observed that genetic MBL ablation strongly sensitizes mice to sterile liver injury induced by carbon tetrachloride (CCl4 ).	Carbon Tetrachloride	103-123	mannose-binding lectin (protein C) 2	Mus musculus	30-33
30706943-0	2019	Mannan-binding lectin attenuates acetaminophen-induced hepatotoxicity by regulating CYP2E1 expression via ROS-dependent JNK/SP1 pathway.	Acetaminophen	33-46	mannose-binding lectin (protein C) 2	Mus musculus	0-21
30706943-0	2019	Mannan-binding lectin attenuates acetaminophen-induced hepatotoxicity by regulating CYP2E1 expression via ROS-dependent JNK/SP1 pathway.	Reactive Oxygen Species	106-109	mannose-binding lectin (protein C) 2	Mus musculus	0-21
30706943-3	2019	In the present study, we investigated the pathophysiological role of MBL in acetaminophen (APAP)-induced hepatotoxicity.	Acetaminophen	76-89	mannose-binding lectin (protein C) 2	Mus musculus	69-72
30706943-3	2019	In the present study, we investigated the pathophysiological role of MBL in acetaminophen (APAP)-induced hepatotoxicity.	Acetaminophen	91-95	mannose-binding lectin (protein C) 2	Mus musculus	69-72
30706943-4	2019	After APAP treatment, MBL-deficient (MBL-/- ) mice had significantly higher mortality and aggravated hepatic necrosis as well as elevated serum lactate dehydrogenase and alanine aminotransferase levels compared to control mice.	Acetaminophen	6-10	mannose-binding lectin (protein C) 2	Mus musculus	22-25
30706943-5	2019	The enhanced hepatotoxicity in MBL-/- mice was associated with increased concentration of APAP toxic metabolisms.	Acetaminophen	90-94	mannose-binding lectin (protein C) 2	Mus musculus	31-34
30706943-6	2019	Furthermore, we demonstrated here that genetic ablation of MBL resulted in excessive reactive oxygen species (ROS) production and enhanced c-Jun N-terminal kinase (JNK) activation, leading to up-regulated specificity protein 1 (SP1) nuclear expression, thus promoted CYP2E1 hepatic expression and consequently exacerbated APAP-induced liver injury in mice.	Reactive Oxygen Species	85-108	mannose-binding lectin (protein C) 2	Mus musculus	59-62
30706943-6	2019	Furthermore, we demonstrated here that genetic ablation of MBL resulted in excessive reactive oxygen species (ROS) production and enhanced c-Jun N-terminal kinase (JNK) activation, leading to up-regulated specificity protein 1 (SP1) nuclear expression, thus promoted CYP2E1 hepatic expression and consequently exacerbated APAP-induced liver injury in mice.	Reactive Oxygen Species	110-113	mannose-binding lectin (protein C) 2	Mus musculus	59-62
30706943-6	2019	Furthermore, we demonstrated here that genetic ablation of MBL resulted in excessive reactive oxygen species (ROS) production and enhanced c-Jun N-terminal kinase (JNK) activation, leading to up-regulated specificity protein 1 (SP1) nuclear expression, thus promoted CYP2E1 hepatic expression and consequently exacerbated APAP-induced liver injury in mice.	Acetaminophen	322-326	mannose-binding lectin (protein C) 2	Mus musculus	59-62
30457677-0	2019	Decreased nematode clearance and anti-phosphorylcholine-specific IgM responses in mannose-binding lectin-deficient mice.	Phosphorylcholine	38-55	mannose-binding lectin (protein C) 2	Mus musculus	82-104
30457677-9	2019	However, absence of MBL-A and/or MBL-C resulted in reduced IgM to phosphorylcholine, a constituent of filarial and bacterial antigens, suggesting that inability to form proficient antibody responses to this moiety leads to lack of microfilarial clearance and overall susceptibility to filariasis.	Phosphorylcholine	66-83	mannose-binding lectin (protein C) 2	Mus musculus	33-38
30713782-6	2019	Mechanistic studies revealed that MBL could interact directly with HSCs and inhibit HCC-induced HSCs activation via downregulating the extracellular signal-regulated kinase (ERK)/COX-2/PGE2 signaling pathway.	Dinoprostone	185-189	mannose-binding lectin (protein C) 2	Mus musculus	34-37
30008719-6	2018	The core oligosaccharide region of H. alvei LPS was identified as the main target for human and murine MBL, especially l-glycero-d-manno-heptose (Hep) and N-acetyl-d-glucosamine (GlcNAc) residues within the outer core region.	Oligosaccharides	9-24	mannose-binding lectin (protein C) 2	Mus musculus	103-106
30008719-6	2018	The core oligosaccharide region of H. alvei LPS was identified as the main target for human and murine MBL, especially l-glycero-d-manno-heptose (Hep) and N-acetyl-d-glucosamine (GlcNAc) residues within the outer core region.	glycero-manno-heptose	119-144	mannose-binding lectin (protein C) 2	Mus musculus	103-106
30008719-6	2018	The core oligosaccharide region of H. alvei LPS was identified as the main target for human and murine MBL, especially l-glycero-d-manno-heptose (Hep) and N-acetyl-d-glucosamine (GlcNAc) residues within the outer core region.	Acetylglucosamine	179-185	mannose-binding lectin (protein C) 2	Mus musculus	103-106
30008719-9	2018	The LPS core oligosaccharide-MBL interactions led to complement activation and also induced an anaphylactoid shock in mice.	Oligosaccharides	13-28	mannose-binding lectin (protein C) 2	Mus musculus	29-32
27165013-4	2017	In vitro surface plasmon resonance assay indicated that Polyman9 dose-dependently inhibits the binding to immobilized mannose residues of plasma mannose-binding lectin-C selectively over that of mannose-binding lectin-A.	Mannose	118-125	mannose-binding lectin (protein C) 2	Mus musculus	145-169
29892304-4	2018	Mannose-binding lectin (MBL)-associated serine proteases (MASPs), which are associated with humoral pattern recognition molecules (MBL or ficolins), are the enzymatic constituents of the LP and AP.	Mannose	0-7	mannose-binding lectin (protein C) 2	Mus musculus	24-27
29892304-4	2018	Mannose-binding lectin (MBL)-associated serine proteases (MASPs), which are associated with humoral pattern recognition molecules (MBL or ficolins), are the enzymatic constituents of the LP and AP.	Mannose	0-7	mannose-binding lectin (protein C) 2	Mus musculus	131-134
29892304-4	2018	Mannose-binding lectin (MBL)-associated serine proteases (MASPs), which are associated with humoral pattern recognition molecules (MBL or ficolins), are the enzymatic constituents of the LP and AP.	leucylproline	187-189	mannose-binding lectin (protein C) 2	Mus musculus	24-27
29892304-4	2018	Mannose-binding lectin (MBL)-associated serine proteases (MASPs), which are associated with humoral pattern recognition molecules (MBL or ficolins), are the enzymatic constituents of the LP and AP.	leucylproline	187-189	mannose-binding lectin (protein C) 2	Mus musculus	131-134
26442658-1	2016	Mannose-binding lectin (MBL) is a soluble lectin of the innate immune system that is produced by the liver and secreted into the circulation where it activates the lectin complement pathway, enhances phagocytosis of microorganisms by leukocytes, and modulates inflammation.	Mannose	0-7	mannose-binding lectin (protein C) 2	Mus musculus	24-27
28751823-5	2017	To test this hypothesis, we induced diabetes by injection of low-dose streptozotocin in MBL double-knockout (MBL/DKO) mice.	Streptozocin	70-84	mannose-binding lectin (protein C) 2	Mus musculus	88-91
27378476-2	2016	Here we tested whether the mannose-binding lectin (MBL2), an initiating factor of lectin complement pathway activation, plays a crucial role in STEC HUS.	Mannose	27-34	mannose-binding lectin (protein C) 2	Mus musculus	51-55
26969323-6	2016	The assay measures the inhibitor"s ability to interfere with the binding of murine MBL-A or MBL-C, or of human recombinant MBL, to mannose residues immobilized on the sensor chip surface.	Mannose	131-138	mannose-binding lectin (protein C) 2	Mus musculus	92-97
27441293-9	2016	CONCLUSION: Unlike previous observations with MBL-producing Enterobacteriaceae that showed discordance between in vitro resistance and in vivo efficacy in the murine infection model, we found that the efficacy of humanized cefepime and meropenem was generally concordant with the phenotypic profile of VIM-producing P. aeruginosa.	Cefepime	223-231	mannose-binding lectin (protein C) 2	Mus musculus	46-49
26442658-6	2016	Blocking MBL by administering mannans to mice increased C. albicans colonization.	Mannans	30-37	mannose-binding lectin (protein C) 2	Mus musculus	9-12
26696414-1	2016	Antagonists of mannose binding lectin (MBL) have shown a protective role against brain reperfusion damage after acute ischemic stroke.	Mannose	15-22	mannose-binding lectin (protein C) 2	Mus musculus	39-42
26696414-2	2016	Here we describe the design and streamlined synthesis of glycomimetic MBL antagonists based on a new tetravalent dendron scaffold.	dendron	113-120	mannose-binding lectin (protein C) 2	Mus musculus	70-73
26696414-3	2016	The dendron was developed by optimisation of a known polyester structure previously demonstrated to be very efficient for ligand presentation to MBL.	dendron	4-11	mannose-binding lectin (protein C) 2	Mus musculus	145-148
26696414-5	2016	The glycoconjugate constructs become stable to silica gel chromatography and to water solutions at physiological pH, while preserving water solubility and activity in an SPR assay against the murine MBL-C isoform.	Water	134-139	mannose-binding lectin (protein C) 2	Mus musculus	199-204
25548381-3	2015	The recognition molecules of the lectin pathway of complement activation, mannose-binding lectin (MBL), ficolins, and CL-11, bind to specific carbohydrates on pathogens, triggering complement activation through MBL-associated serine protease-2 (MASP-2).	Mannose	74-81	mannose-binding lectin (protein C) 2	Mus musculus	98-101
26977416-4	2016	The lectin pathway of the complement system, initiated by the carbohydrate-recognition molecule mannan-binding lectin (MBL), is linked to poor kidney prognosis in diabetes.	Carbohydrates	62-74	mannose-binding lectin (protein C) 2	Mus musculus	96-117
26977416-4	2016	The lectin pathway of the complement system, initiated by the carbohydrate-recognition molecule mannan-binding lectin (MBL), is linked to poor kidney prognosis in diabetes.	Carbohydrates	62-74	mannose-binding lectin (protein C) 2	Mus musculus	119-122
25293413-2	2015	Using mice deficient in C1q/mannose-binding lectin (MBL) or C3, we demonstrated an important role for these opsonins and/or the classical pathway C3 convertase in providing protection against mucosal injury and infection in a model of chronic dextran sulphate sodium (DSS)-induced colitis.	dextran sulphate sodium	243-266	mannose-binding lectin (protein C) 2	Mus musculus	24-50
25293413-2	2015	Using mice deficient in C1q/mannose-binding lectin (MBL) or C3, we demonstrated an important role for these opsonins and/or the classical pathway C3 convertase in providing protection against mucosal injury and infection in a model of chronic dextran sulphate sodium (DSS)-induced colitis.	dextran sulphate sodium	243-266	mannose-binding lectin (protein C) 2	Mus musculus	52-55
25293413-2	2015	Using mice deficient in C1q/mannose-binding lectin (MBL) or C3, we demonstrated an important role for these opsonins and/or the classical pathway C3 convertase in providing protection against mucosal injury and infection in a model of chronic dextran sulphate sodium (DSS)-induced colitis.	dss	268-271	mannose-binding lectin (protein C) 2	Mus musculus	24-50
25293413-2	2015	Using mice deficient in C1q/mannose-binding lectin (MBL) or C3, we demonstrated an important role for these opsonins and/or the classical pathway C3 convertase in providing protection against mucosal injury and infection in a model of chronic dextran sulphate sodium (DSS)-induced colitis.	dss	268-271	mannose-binding lectin (protein C) 2	Mus musculus	52-55
25482922-7	2015	Monoclonal antibody 3F8 inhibited C3 deposition on mannan-coated plates in MBL2 KI, but not wild-type, mice.	Mannans	51-57	mannose-binding lectin (protein C) 2	Mus musculus	75-79
26629697-2	2015	Our results showed that jacaric acid exhibited no significant cytotoxicity on the thioglycollate-elicited murine peritoneal macrophages as revealed by the neutral red uptake assay, but markedly increased their cytostatic activity on the T-cell lymphoma MBL-2 cells as measured by the fluorometric CyQuant  NF Cell Proliferation Assay Kit.	jacaric acid	24-36	mannose-binding lectin (protein C) 2	Mus musculus	253-258
25548381-3	2015	The recognition molecules of the lectin pathway of complement activation, mannose-binding lectin (MBL), ficolins, and CL-11, bind to specific carbohydrates on pathogens, triggering complement activation through MBL-associated serine protease-2 (MASP-2).	Mannose	74-81	mannose-binding lectin (protein C) 2	Mus musculus	211-214
25548381-3	2015	The recognition molecules of the lectin pathway of complement activation, mannose-binding lectin (MBL), ficolins, and CL-11, bind to specific carbohydrates on pathogens, triggering complement activation through MBL-associated serine protease-2 (MASP-2).	cl-11	118-123	mannose-binding lectin (protein C) 2	Mus musculus	211-214
25548381-3	2015	The recognition molecules of the lectin pathway of complement activation, mannose-binding lectin (MBL), ficolins, and CL-11, bind to specific carbohydrates on pathogens, triggering complement activation through MBL-associated serine protease-2 (MASP-2).	Carbohydrates	142-155	mannose-binding lectin (protein C) 2	Mus musculus	98-101
25548381-3	2015	The recognition molecules of the lectin pathway of complement activation, mannose-binding lectin (MBL), ficolins, and CL-11, bind to specific carbohydrates on pathogens, triggering complement activation through MBL-associated serine protease-2 (MASP-2).	Carbohydrates	142-155	mannose-binding lectin (protein C) 2	Mus musculus	211-214
24965651-8	2014	In mice infected with NDM-1-expressing Klebsiella pneumoniae, AMA efficiently restored meropenem activity, demonstrating that a combination of AMA and a carbapenem antibiotic has therapeutic potential to address the clinical challenge of MBL-positive carbapenem-resistant Gram-negative pathogens.	Carbapenems	153-163	mannose-binding lectin (protein C) 2	Mus musculus	238-241
25419660-0	2014	Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin.	Lysine	29-35	mannose-binding lectin (protein C) 2	Mus musculus	78-99
25419660-4	2014	Furthermore, loss of the terminal glucose units on the derivatized lysine residues in mouse embryonic fibroblasts lacking the LH3 protein leads to defective disulphide bonding and oligomerization of rat MBL-A, with a decrease in the proportion of the larger functional MBL oligomers.	Glucose	34-41	mannose-binding lectin (protein C) 2	Mus musculus	203-206
25419660-4	2014	Furthermore, loss of the terminal glucose units on the derivatized lysine residues in mouse embryonic fibroblasts lacking the LH3 protein leads to defective disulphide bonding and oligomerization of rat MBL-A, with a decrease in the proportion of the larger functional MBL oligomers.	Lysine	67-73	mannose-binding lectin (protein C) 2	Mus musculus	203-206
25419660-9	2014	Our data suggest that LH3 is commonly involved in biosynthesis of collagenous proteins and the glucosylation of galactosylhydroxylysines residues by LH3 is crucial for the formation of the functional high-molecular weight MBL oligomers.	galactosylhydroxylysine	112-136	mannose-binding lectin (protein C) 2	Mus musculus	222-225
25070856-2	2014	MBL, ficolins and collectin-11 are key LP pattern recognition molecules that associate with three serine proteases-MASP-1, MASP-2, and MASP-3-and with two MBL-associated proteins designated sMAP and MBL-associated protein of 44kDA (MAp44).	leucylproline	39-41	mannose-binding lectin (protein C) 2	Mus musculus	0-3
25070856-2	2014	MBL, ficolins and collectin-11 are key LP pattern recognition molecules that associate with three serine proteases-MASP-1, MASP-2, and MASP-3-and with two MBL-associated proteins designated sMAP and MBL-associated protein of 44kDA (MAp44).	leucylproline	39-41	mannose-binding lectin (protein C) 2	Mus musculus	155-158
25070856-2	2014	MBL, ficolins and collectin-11 are key LP pattern recognition molecules that associate with three serine proteases-MASP-1, MASP-2, and MASP-3-and with two MBL-associated proteins designated sMAP and MBL-associated protein of 44kDA (MAp44).	leucylproline	39-41	mannose-binding lectin (protein C) 2	Mus musculus	155-158
24965651-8	2014	In mice infected with NDM-1-expressing Klebsiella pneumoniae, AMA efficiently restored meropenem activity, demonstrating that a combination of AMA and a carbapenem antibiotic has therapeutic potential to address the clinical challenge of MBL-positive carbapenem-resistant Gram-negative pathogens.	Carbapenems	251-261	mannose-binding lectin (protein C) 2	Mus musculus	238-241
23936347-6	2013	Intradermal immunization with WTA elicited and augmented an anti-WTA IgG response in both WT and MBL KO mice.	5'-O-[(S)-ethoxy(hydroxy)phosphoryl]adenosine	30-33	mannose-binding lectin (protein C) 2	Mus musculus	97-100
24676774-13	2014	Argatroban protects WT mice, but not MBL knockout mice, emphasizing a role of MBL in local thrombus formation in acute ischemia/reperfusion.	argatroban	0-10	mannose-binding lectin (protein C) 2	Mus musculus	78-81
22079428-4	2012	Hyperglycemia was induced in wild-type (WT) C57BL/6 and MBL-null mice after streptozotocin administration.	Streptozocin	76-90	mannose-binding lectin (protein C) 2	Mus musculus	56-59
23884105-5	2013	These results suggest that mouse MBL-A and ficolin-A bind to LPS via its carbohydrate-recognition domain and fibrinogen-like domain, respectively, whereby cytokine production by LPS-mediated TLR4 in mBMMCs appears to be down-regulated, indicating that mouse MBL and ficolin may have an inhibitory function toward mouse TLR4-mediated excessive inflammation on the mast cells.	Carbohydrates	73-85	mannose-binding lectin (protein C) 2	Mus musculus	33-36
23350935-5	2013	We measured plasma MBL before and 7 weeks after inducing diabetes by streptozotocin.	Streptozocin	69-83	mannose-binding lectin (protein C) 2	Mus musculus	19-22
23350935-8	2013	The increase in MBL-C was associated with the increasing plasma glucose levels.	Glucose	64-71	mannose-binding lectin (protein C) 2	Mus musculus	16-21
23350935-13	2013	We demonstrate for the first time that MBL levels increase after induction of diabetes and in parallel with increasing plasma glucose.	Glucose	126-133	mannose-binding lectin (protein C) 2	Mus musculus	39-42
23032324-3	2012	We have recently shown that the lectin pathway-specific carbohydrate recognition subcomponent mannose-binding lectin plays an essential role in the pathophysiology of thrombosis and ischemia/reperfusion injury.	Carbohydrates	56-68	mannose-binding lectin (protein C) 2	Mus musculus	94-116
22156595-4	2012	In contrast, mannose-binding lectin (MBL)-null and MBL-associated serine protease (MASP)-1/-3 knockout (KO) mice had significantly decreased FeCl(3)-induced thrombogenesis.	ferric chloride	141-148	mannose-binding lectin (protein C) 2	Mus musculus	13-35
22156595-4	2012	In contrast, mannose-binding lectin (MBL)-null and MBL-associated serine protease (MASP)-1/-3 knockout (KO) mice had significantly decreased FeCl(3)-induced thrombogenesis.	ferric chloride	141-148	mannose-binding lectin (protein C) 2	Mus musculus	37-40
22156595-5	2012	Reconstitution with recombinant human (rh) MBL restored FeCl(3)-induced thrombogenesis in MBL-null mice to levels comparable to WT mice, suggesting a significant role of the MBL/MASP complex for in vivo coagulation.	ferric chloride	56-63	mannose-binding lectin (protein C) 2	Mus musculus	90-93
22156595-7	2012	In vitro, MBL/MASP complexes were captured on mannan-coated plates, and cleavage of a chromogenic thrombin substrate (S2238) was measured.	Mannans	46-52	mannose-binding lectin (protein C) 2	Mus musculus	10-13
21490619-4	2011	However, induction of skin inflammation by one topical application of DNFB following MBL2 inoculation in C57BL/6 mice resulted in progressive high-grade lymphoma.	Dinitrofluorobenzene	70-74	mannose-binding lectin (protein C) 2	Mus musculus	85-89
22645604-9	2012	In both strains, experimental type 1 diabetes was induced in wild-type (WT) and MBL-knockout (MBL-KO) mice by streptozotocin.	Streptozocin	110-124	mannose-binding lectin (protein C) 2	Mus musculus	80-83
21865552-1	2011	Mannose-binding lectin (MBL)-associated serine proteases (MASPs) are responsible for activation of the lectin complement pathway.	Mannose	0-7	mannose-binding lectin (protein C) 2	Mus musculus	24-27
21943708-7	2011	Furthermore, sera from MBL(-/-)/FCN A(-/-) mice lacked pro-Df and possessed only mature Df.	pro-df	55-61	mannose-binding lectin (protein C) 2	Mus musculus	23-26
22080095-1	2012	BACKGROUND: Mannose-binding lectin (MBL) is a pattern-recognition molecule, which functions as a first line of host defense.	Mannose	12-19	mannose-binding lectin (protein C) 2	Mus musculus	36-39
22080095-6	2012	RESULTS: Our study demonstrated that in vitro, MBL binds to pdmH1N1 and H9N2/G1 viruses, likely via the carbohydrate recognition domain of MBL.	Carbohydrates	104-116	mannose-binding lectin (protein C) 2	Mus musculus	47-50
22080095-6	2012	RESULTS: Our study demonstrated that in vitro, MBL binds to pdmH1N1 and H9N2/G1 viruses, likely via the carbohydrate recognition domain of MBL.	Carbohydrates	104-116	mannose-binding lectin (protein C) 2	Mus musculus	139-142
22505955-2	2011	Recent work has demonstrated that genetic-deficiency of Mannose-binding lectin(MBL) ameliorates reperfusion injury and improves outcome in the acute phase of stroke.	Mannose	56-63	mannose-binding lectin (protein C) 2	Mus musculus	79-82
21490619-6	2011	At 2 days after implantation, a 10-fold decrease in MBL2 cell apoptosis was detected in DNFB-treated ears compared with vehicle control.	Dinitrofluorobenzene	88-92	mannose-binding lectin (protein C) 2	Mus musculus	52-56
21294904-4	2011	The mortality of mice infected with a seasonal H1N1 influenza virus was evidently enhanced on transient blockage of MBL activity by simultaneous inoculation of mannan, whereas mannan inoculation had no effect on mice infected with a pandemic 2009 virus.	Mannans	160-166	mannose-binding lectin (protein C) 2	Mus musculus	116-119
21208161-3	2011	Activation of the CS via mannose binding lectin (MBL)-initiated lectin pathway is known to increase tissue damage in response to IR in muscle, myocardium and intestine tissue.	Cesium	18-20	mannose-binding lectin (protein C) 2	Mus musculus	25-47
21208161-3	2011	Activation of the CS via mannose binding lectin (MBL)-initiated lectin pathway is known to increase tissue damage in response to IR in muscle, myocardium and intestine tissue.	Cesium	18-20	mannose-binding lectin (protein C) 2	Mus musculus	49-52
20682699-0	2010	Mannan-binding lectin deficiency results in unusual antibody production and excessive experimental colitis in response to mannose-expressing mild gut pathogens.	Mannose	122-129	mannose-binding lectin (protein C) 2	Mus musculus	0-21
20709295-6	2010	Experiments in mice showed an MBL-dependent accelerated intravascular clearance of DENV or a WNV mutant with two N-linked glycans on its E protein, but not with wild-type WNV.	n-linked glycans	113-129	mannose-binding lectin (protein C) 2	Mus musculus	30-33
21182784-1	2010	BACKGROUND: Mannose-binding lectin (MBL), a pattern recognition innate immune molecule, inhibits influenza A virus infection in vitro.	Mannose	12-19	mannose-binding lectin (protein C) 2	Mus musculus	36-39
20438576-8	2010	For both implant systems, PCP showed statistically significantly higher mBL rates and number of sites with BL> or =3 mm compared with PHP (P<0.0001).	pcp	26-29	mannose-binding lectin (protein C) 2	Mus musculus	72-75
20438576-8	2010	For both implant systems, PCP showed statistically significantly higher mBL rates and number of sites with BL> or =3 mm compared with PHP (P<0.0001).	pcp	26-29	mannose-binding lectin (protein C) 2	Mus musculus	73-75