PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
6171425-1	1981	Human thyroglobulin mRNA was isolated from Graves" goitres by size selection of total poly(A)-rich RNA in a sucrose gradient.	Sucrose	108-115	thyroglobulin	Homo sapiens	6-19
7307280-0	1981	Autoantibodies to thyroglobulin cross reacting with iodothyronines.	iodothyronines	52-66	thyroglobulin	Homo sapiens	18-31
7323647-2	1981	The crude Tgl was prepared from thyroid glands surgically removed for colloid goiter by ammonium sulphate fractionation.	Ammonium Sulfate	88-105	thyroglobulin	Homo sapiens	10-13
7323647-3	1981	Two purified Tgls were obtained by gel filtration on Sephadex G-200 (Tgl-200) and by preparative polyacrylamide gel electrophoresis (Tgl-PAGE).	sephadex	53-67	thyroglobulin	Homo sapiens	13-16
6114108-4	1981	Tg (3 X 10(-8) M) caused a significant reduction in the TSH- and TSI-stimulated adenylate cyclase activities, but did not influence stimulation with NaF (8 mM).	Thyrotropin	56-59	thyroglobulin	Homo sapiens	0-2
6114108-6	1981	Thus, Tg is an efficient inhibitor of basal and TSH- or TSI- stimulated adenylate cyclase activities, and might be involved in a short loop counterregulation of thyroid adenylate cyclase sensitivity in vivo.	Thyrotropin	48-51	thyroglobulin	Homo sapiens	6-8
7260125-1	1981	Properties of tryptophane and tyrosine fluorescence of intact and iodinated thyroglobulin from normal human thyroid and nodular euthyroid goiter were studied.	Tyrosine	30-38	thyroglobulin	Homo sapiens	76-89
6267713-1	1981	Thyroid peroxidase in involved in several steps of the biosynthesis of thyroid hormone utilizing H2O2: peroxidation of iodide to iodine, iodination of thyroglobulin (Tg) and coupling reaction leading to T4 and T3 formation.	Hydrogen Peroxide	97-101	thyroglobulin	Homo sapiens	151-164
6267713-1	1981	Thyroid peroxidase in involved in several steps of the biosynthesis of thyroid hormone utilizing H2O2: peroxidation of iodide to iodine, iodination of thyroglobulin (Tg) and coupling reaction leading to T4 and T3 formation.	Iodides	119-125	thyroglobulin	Homo sapiens	151-164
6267713-1	1981	Thyroid peroxidase in involved in several steps of the biosynthesis of thyroid hormone utilizing H2O2: peroxidation of iodide to iodine, iodination of thyroglobulin (Tg) and coupling reaction leading to T4 and T3 formation.	Iodine	129-135	thyroglobulin	Homo sapiens	151-164
7260125-2	1981	It has been shown that practically all (95%) tryptophane residues in "normal" thyroglobulin are in the inner regions of the globule.	Tryptophan	45-56	thyroglobulin	Homo sapiens	78-91
7260125-3	1981	In "pathological" thyroglobulin in the regions inaccessible for water there are located only 68% of trypthophanyls.	Water	64-69	thyroglobulin	Homo sapiens	18-31
7260125-3	1981	In "pathological" thyroglobulin in the regions inaccessible for water there are located only 68% of trypthophanyls.	trypthophanyls	100-114	thyroglobulin	Homo sapiens	18-31
7260125-4	1981	After iodination only in "pathological" thyroglobulin redistribution of tryptophan residues takes place on the surface and inside the globule.	Tryptophan	72-82	thyroglobulin	Homo sapiens	40-53
6185989-2	1981	After 4 days of culture and 1-hr labelling with 35S Met, Tgb specific radioactivity was 10 times higher in TSH-treated cells than in control cells.	Sulfur-35	48-51	thyroglobulin	Homo sapiens	57-60
7240667-0	1981	The effect of 131I for diagnostic purposes on serum thyroglobulin (hTg) levels in subjects with thyroidal disorders.	Iodine-131	14-18	thyroglobulin	Homo sapiens	52-65
7240667-1	1981	The concentration of serum thyroglobulin was measured in sera of subjects with various thyroid disorders, before and after the administration of tracer doses of 131I.	Iodine-131	161-165	thyroglobulin	Homo sapiens	27-40
6185989-2	1981	After 4 days of culture and 1-hr labelling with 35S Met, Tgb specific radioactivity was 10 times higher in TSH-treated cells than in control cells.	Thyrotropin	107-110	thyroglobulin	Homo sapiens	57-60
6185989-6	1981	ii) The relative amount of Tgb mRNA in the cytoplasm of TSH-treated cells was 3 times higher than in the control cells.	Thyrotropin	56-59	thyroglobulin	Homo sapiens	27-30
6185989-7	1981	This correlates with the fact that Tgb biosynthesis relative to total protein synthesis increased similarly, indicating that TSH controls relative Tgb biosynthesis by specifically regulating cytoplasmic Tgb mRNA content.	Thyrotropin	125-128	thyroglobulin	Homo sapiens	35-38
6185989-7	1981	This correlates with the fact that Tgb biosynthesis relative to total protein synthesis increased similarly, indicating that TSH controls relative Tgb biosynthesis by specifically regulating cytoplasmic Tgb mRNA content.	Thyrotropin	125-128	thyroglobulin	Homo sapiens	147-150
6185989-7	1981	This correlates with the fact that Tgb biosynthesis relative to total protein synthesis increased similarly, indicating that TSH controls relative Tgb biosynthesis by specifically regulating cytoplasmic Tgb mRNA content.	Thyrotropin	125-128	thyroglobulin	Homo sapiens	147-150
6257543-0	1980	Inhibition of thyrotropin-stimulated cyclic AMP accumulation by human thyroglobulin in human cultured thyroid cells.	Cyclic AMP	37-47	thyroglobulin	Homo sapiens	70-83
7439190-2	1980	The mixture of CNBr peptides obtained by treatment of porcine thyroglobulin with cyanogen bromide was separated into three fractions by Sephadex G-200 gel filtration in 1 M propionic acid.	Cyanogen Bromide	81-97	thyroglobulin	Homo sapiens	62-75
7439190-11	1980	It was shown that the number of thyroxine and triiodothyronine residues increased linearly with increasing thyroglobulin iodine content in the range 0.73-1.6% and reached six residues of thyroxine and two residues of triiodothyronine/mol protein for a thyroglobulin iodine content of 1.6% with no indication of saturation.	Thyroxine	32-41	thyroglobulin	Homo sapiens	107-120
7439190-11	1980	It was shown that the number of thyroxine and triiodothyronine residues increased linearly with increasing thyroglobulin iodine content in the range 0.73-1.6% and reached six residues of thyroxine and two residues of triiodothyronine/mol protein for a thyroglobulin iodine content of 1.6% with no indication of saturation.	Thyroxine	32-41	thyroglobulin	Homo sapiens	252-265
7439190-11	1980	It was shown that the number of thyroxine and triiodothyronine residues increased linearly with increasing thyroglobulin iodine content in the range 0.73-1.6% and reached six residues of thyroxine and two residues of triiodothyronine/mol protein for a thyroglobulin iodine content of 1.6% with no indication of saturation.	Triiodothyronine	46-62	thyroglobulin	Homo sapiens	107-120
7439190-11	1980	It was shown that the number of thyroxine and triiodothyronine residues increased linearly with increasing thyroglobulin iodine content in the range 0.73-1.6% and reached six residues of thyroxine and two residues of triiodothyronine/mol protein for a thyroglobulin iodine content of 1.6% with no indication of saturation.	Triiodothyronine	46-62	thyroglobulin	Homo sapiens	252-265
7439190-11	1980	It was shown that the number of thyroxine and triiodothyronine residues increased linearly with increasing thyroglobulin iodine content in the range 0.73-1.6% and reached six residues of thyroxine and two residues of triiodothyronine/mol protein for a thyroglobulin iodine content of 1.6% with no indication of saturation.	Iodine	121-127	thyroglobulin	Homo sapiens	107-120
7439190-11	1980	It was shown that the number of thyroxine and triiodothyronine residues increased linearly with increasing thyroglobulin iodine content in the range 0.73-1.6% and reached six residues of thyroxine and two residues of triiodothyronine/mol protein for a thyroglobulin iodine content of 1.6% with no indication of saturation.	Iodine	121-127	thyroglobulin	Homo sapiens	252-265
7439190-11	1980	It was shown that the number of thyroxine and triiodothyronine residues increased linearly with increasing thyroglobulin iodine content in the range 0.73-1.6% and reached six residues of thyroxine and two residues of triiodothyronine/mol protein for a thyroglobulin iodine content of 1.6% with no indication of saturation.	Thyroxine	187-196	thyroglobulin	Homo sapiens	107-120
7439190-11	1980	It was shown that the number of thyroxine and triiodothyronine residues increased linearly with increasing thyroglobulin iodine content in the range 0.73-1.6% and reached six residues of thyroxine and two residues of triiodothyronine/mol protein for a thyroglobulin iodine content of 1.6% with no indication of saturation.	Triiodothyronine	217-233	thyroglobulin	Homo sapiens	107-120
7439190-11	1980	It was shown that the number of thyroxine and triiodothyronine residues increased linearly with increasing thyroglobulin iodine content in the range 0.73-1.6% and reached six residues of thyroxine and two residues of triiodothyronine/mol protein for a thyroglobulin iodine content of 1.6% with no indication of saturation.	Iodine	266-272	thyroglobulin	Homo sapiens	107-120
7439190-12	1980	This result is at variance with previous findings on porcine thyroglobulin iodinated in vivo which suggested that the thyroxine content reached a plateau of three to four residues/molecule for an iodine content comprised between 0.7% and 1.1%.	Thyroxine	118-127	thyroglobulin	Homo sapiens	61-74
7380994-1	1980	We have studied human thyroglobulin of extremely low iodine content obtained from a goitrous cretin who had no measurable peroxidase activity in his thyroid gland.	Iodine	53-59	thyroglobulin	Homo sapiens	22-35
7230893-0	1980	[Labeling of thyroglobulin with iodine isotope 125].	Iodine	32-38	thyroglobulin	Homo sapiens	13-26
115215-5	1979	It was suggested that iodine and sulphur reflect the presence of thyroglobulin in the colloid of thyroid follicles.	Iodine	22-28	thyroglobulin	Homo sapiens	65-78
7416187-0	1980	Serum thyroglobulin levels predict total body iodine scan findings in patients with treated well-differentiated thyroid carcinoma.	Iodine	46-52	thyroglobulin	Homo sapiens	6-19
7371974-4	1980	Cylindrical thyroglobulin molecules (from PTU-exposed thyroids) were incubated in different media and the proportion of cylindrical and ovoid molecules after incubation was estimated in electron micrographs.	Phenylthiourea	42-45	thyroglobulin	Homo sapiens	12-25
6930757-5	1980	Evaluation of the present results suggests that an insufficient synthesis of thyroglobulin in the examined goitres induces an inadequate adaptation of the organism to iodine deficiency, which, in turn, decreases the thyroid hormone concentration in thyroid tissue and enhances goitrogenesis.	Iodine	167-173	thyroglobulin	Homo sapiens	77-90
6930757-6	1980	Considering the normal iodine content of the examined tissues, there obviously seems to be two intrathyroidal iodine pools, one of which supplies the body with thyroid hormones under pituitary stimulation even though its thyroglobulin pool is reduced, while a significant amount of the thyroidal iodine pool is bound in metabolically inert protein molecules and therefore increases the goitrogenic effect of iodine deficiency.	Iodine	110-116	thyroglobulin	Homo sapiens	221-234
6930757-6	1980	Considering the normal iodine content of the examined tissues, there obviously seems to be two intrathyroidal iodine pools, one of which supplies the body with thyroid hormones under pituitary stimulation even though its thyroglobulin pool is reduced, while a significant amount of the thyroidal iodine pool is bound in metabolically inert protein molecules and therefore increases the goitrogenic effect of iodine deficiency.	Iodine	110-116	thyroglobulin	Homo sapiens	221-234
7392641-0	1980	Effect of TSH stimulation on serum thyroglobulin in metastatic thyroid cancer.	Thyrotropin	10-13	thyroglobulin	Homo sapiens	35-48
476925-0	1979	Rapid analysis for iodotyrosines and iodothyronines in thyroglobulin by reversed-phase liquid chromatography.	Monoiodotyrosine	19-32	thyroglobulin	Homo sapiens	55-68
476925-0	1979	Rapid analysis for iodotyrosines and iodothyronines in thyroglobulin by reversed-phase liquid chromatography.	iodothyronines	37-51	thyroglobulin	Homo sapiens	55-68
227208-9	1979	We postulate that the fundamental defect in this gland is an impaired generation of c-AMP by the defective thyroid cell and deficiency of thyroglobulin formation resulting in inadequate thyroxine and triiodothyronine synthesis.	Thyroxine	186-195	thyroglobulin	Homo sapiens	138-151
227208-9	1979	We postulate that the fundamental defect in this gland is an impaired generation of c-AMP by the defective thyroid cell and deficiency of thyroglobulin formation resulting in inadequate thyroxine and triiodothyronine synthesis.	Triiodothyronine	200-216	thyroglobulin	Homo sapiens	138-151
482130-4	1979	Conversely, TSH maintained the initial Tgb mRNA level in cells cultured in its presence, and TSH concentrations 50 micronU/ml or 5 mU/ml gave identical results.	Thyrotropin	12-15	thyroglobulin	Homo sapiens	39-42
221458-5	1979	Although salts can inhibit or enhance thyroglobulin binding depending on the temperature or pH, conditions approaching those of the physiological state are not inhibitory; physiological conditions do inhibit thyrotropin binding to the same membrane preparations.	Salts	9-14	thyroglobulin	Homo sapiens	38-51
221458-6	1979	125I-Labeled thyroglobulin binding is poorly reversed by unlabeled thyroglobulin at all pH values and temperatures studied; excess unlabeled thyroglobulin can, however, readily prevent binding.	Iodine-125	0-4	thyroglobulin	Homo sapiens	13-26
221458-7	1979	At pH values greater than 6.0 and at 0 degrees C, the iodine content of thyroglobulin can affect binding, and the 27 S thyroid iodoprotein is relatively ineffective in preventing the binding of the 19 S species.	Iodine	54-60	thyroglobulin	Homo sapiens	72-85
397069-8	1979	2) Another method using human thyroglobulin conjugated with beta-D-galactosidase and silicone rod coated with human thyroglobulin was developed for the measurement of circulating (anti-human thyroglobulin) autoantibody.	Silicones	85-93	thyroglobulin	Homo sapiens	116-129
397069-8	1979	2) Another method using human thyroglobulin conjugated with beta-D-galactosidase and silicone rod coated with human thyroglobulin was developed for the measurement of circulating (anti-human thyroglobulin) autoantibody.	Silicones	85-93	thyroglobulin	Homo sapiens	116-129
115215-5	1979	It was suggested that iodine and sulphur reflect the presence of thyroglobulin in the colloid of thyroid follicles.	Sulfur	33-40	thyroglobulin	Homo sapiens	65-78
760516-5	1979	Substitution of levothyroxine for thyroglobulin was done in all patients and was associated with return to normal of serum triiodothyronine (T3) values in those tested.	Triiodothyronine	123-139	thyroglobulin	Homo sapiens	34-47
570542-2	1978	A small peak in the amino acid analysis of hog thyroglobulin was observed in the region reported for lysinoalanine and galactosamine.	Lysinoalanine	101-114	thyroglobulin	Homo sapiens	47-60
760516-5	1979	Substitution of levothyroxine for thyroglobulin was done in all patients and was associated with return to normal of serum triiodothyronine (T3) values in those tested.	Triiodothyronine	141-143	thyroglobulin	Homo sapiens	34-47
570542-2	1978	A small peak in the amino acid analysis of hog thyroglobulin was observed in the region reported for lysinoalanine and galactosamine.	Galactosamine	119-132	thyroglobulin	Homo sapiens	47-60
570542-5	1978	Approximately 5 moles of galactosamine were found per mole of thyroglobulin.	Galactosamine	25-38	thyroglobulin	Homo sapiens	62-75
78781-5	1978	Analysis by sucrose gradient centrifugation and double diffusion in agar gel showed that fluorescein dissociates thyroglobulin into 12S fragments and reduces its immunoreaction with autoantibodies.	Sucrose	12-19	thyroglobulin	Homo sapiens	113-126
78781-5	1978	Analysis by sucrose gradient centrifugation and double diffusion in agar gel showed that fluorescein dissociates thyroglobulin into 12S fragments and reduces its immunoreaction with autoantibodies.	Agar	68-72	thyroglobulin	Homo sapiens	113-126
78781-5	1978	Analysis by sucrose gradient centrifugation and double diffusion in agar gel showed that fluorescein dissociates thyroglobulin into 12S fragments and reduces its immunoreaction with autoantibodies.	Fluorescein	89-100	thyroglobulin	Homo sapiens	113-126
668129-2	1978	The sequential steps of the procedure include the adsorption of thyroglobulin (Tg) on polystyrene tubes and the binding of the antithyroglobulin antibody to solid phase followed by the fixation of labelled thyroglobulin.	Polystyrenes	86-97	thyroglobulin	Homo sapiens	64-77
204241-6	1978	Elevated serum thyroglobulin levels in all patients with hyperthyroidism fell to normal after surgical resection or radioiodine therapy.	Iodine-131	116-127	thyroglobulin	Homo sapiens	15-28
225342-1	1978	The effect of thyroglobulin (TG) on binding of TSH to thyroid plasma membranes was studied in vitro.	Thyrotropin	47-50	thyroglobulin	Homo sapiens	14-27
225342-1	1978	The effect of thyroglobulin (TG) on binding of TSH to thyroid plasma membranes was studied in vitro.	Thyrotropin	47-50	thyroglobulin	Homo sapiens	29-31
225342-5	1978	Incubation of TG with TSH did not show an interaction, as assessed by sucrose gradient centrifugation.	Thyrotropin	22-25	thyroglobulin	Homo sapiens	14-16
225342-8	1978	In the presence of very high concentrations of TSH, TG binding was increased.	Thyrotropin	47-50	thyroglobulin	Homo sapiens	52-54
225342-10	1978	Both [125I]TSH and [125I]TG binding were inhibited by 10 mM neuraminic acid.	Neuraminic Acids	60-75	thyroglobulin	Homo sapiens	25-27
627059-5	1978	The immunoprecipitable radioactivity reflects the binding capacity of the sample for 125I-labeled thyroglobulin.	Iodine-125	85-89	thyroglobulin	Homo sapiens	98-111
580134-0	1978	Iodoamino acid composition of poorly iodinated human thyroglobulin fractionated by isopycnic centrifugation.	iodoamino acid	0-14	thyroglobulin	Homo sapiens	53-66
580134-6	1978	It is shown here that, even after fractionation of poorly iodinated thyroglobulin, the synthesis of thyroid hormones is observed at a level of iodine content as low as 1.4 and 1.8 atoms per molecule of thyroglobulin.	Iodine	143-149	thyroglobulin	Homo sapiens	68-81
95912-1	1978	A subunit of succinylated (40:1 molar ratio, succinic anhydride:lysine residues) human thyroglobulin (Tg) was prepared by gel filtration on 6% and 4% agarose.	Lysine	64-70	thyroglobulin	Homo sapiens	87-100
95912-1	1978	A subunit of succinylated (40:1 molar ratio, succinic anhydride:lysine residues) human thyroglobulin (Tg) was prepared by gel filtration on 6% and 4% agarose.	Sepharose	150-157	thyroglobulin	Homo sapiens	87-100
594626-3	1977	The RIA of Tgl was applied as a screening test for the in vitro secretory activity of human thyroid cells under the influence of two herbicides of the heterocyclic group (Amitrol and Atrazin).	Amitriptyline	171-178	thyroglobulin	Homo sapiens	11-14
631380-15	1978	After a transient fluctuation caused by the operation, the serum Tg level in the patient increased progressively during 39 days after surgery with a concomitant increase in serum TSH; the levels at the 3rd, 6th and 9th day after surgery were 5,825 ng/ml, 7,910 ng/ml and 11,190 ng/ml, respectively.	Thyrotropin	179-182	thyroglobulin	Homo sapiens	65-67
631380-17	1978	Bovine TSH was administered to this patient at the 114th day, so as to study the effect of exogeneous TSH on serum Tg.	Thyrotropin	102-105	thyroglobulin	Homo sapiens	115-117
631380-21	1978	Despite complete removal of the thyroid gland, the increase in serum Tg after thyroidal stimulation with endogenous and exogenous TSH was observed in the patient.	Thyrotropin	130-133	thyroglobulin	Homo sapiens	69-71
631380-23	1978	These results indicate that the elevated serum Tg was released from metastatic tissue by TSH.	Thyrotropin	89-92	thyroglobulin	Homo sapiens	47-49
670715-6	1978	Ultracentrifugation of 125I-labelled Tg indicated that it had a sedimentation rate corresponding to 19 S.	Iodine-125	23-27	thyroglobulin	Homo sapiens	37-39
594626-3	1977	The RIA of Tgl was applied as a screening test for the in vitro secretory activity of human thyroid cells under the influence of two herbicides of the heterocyclic group (Amitrol and Atrazin).	Atrazine	183-190	thyroglobulin	Homo sapiens	11-14
849453-3	1977	The glycopeptide fraction from alpha1-acid glycoprotein is complex (i.e., the carbohydrate moiety contains mannose, galactose, N-acetylglucosamine, and sailic acid), as is one of the glycopeptide fractions from thyroglobulin (type I).	Glycopeptides	4-16	thyroglobulin	Homo sapiens	211-224
577211-0	1977	Triiodothyronine, thyroxine, and iodine in purified thyroglobulin from patients with Graves" disease.	Triiodothyronine	0-16	thyroglobulin	Homo sapiens	52-65
577211-0	1977	Triiodothyronine, thyroxine, and iodine in purified thyroglobulin from patients with Graves" disease.	Iodine	33-39	thyroglobulin	Homo sapiens	52-65
577211-4	1977	Results of analyses of Tg from six control patients and seven with Graves" disease, not receiving thiourea drugs or iodide, showed that the iodine content of Graves" disease Tg was not different from normal.	Iodine	140-146	thyroglobulin	Homo sapiens	174-176
577211-7	1977	In Tg from patients with treated Graves" disease, iodine, T(3), and T(4) were reduced, but the reduction in the latter was more substantial, resulting in a T(4)/T(3) molar ratio of 3.4+/-1.	Iodine	50-56	thyroglobulin	Homo sapiens	3-5
849453-4	1977	The glycopeptide fraction from ovalbumin and the type II glycopeptide fractions from thyroglobulin are simple (i.e., the carbohydrate moiety contains only mannose and N-acetylglucosamine).	Carbohydrates	121-133	thyroglobulin	Homo sapiens	85-98
849453-4	1977	The glycopeptide fraction from ovalbumin and the type II glycopeptide fractions from thyroglobulin are simple (i.e., the carbohydrate moiety contains only mannose and N-acetylglucosamine).	Acetylglucosamine	167-186	thyroglobulin	Homo sapiens	85-98
576578-5	1977	It is hypothesized that the intracellular accumulation of glycogen may be a result of a selective loss of the peptide portion of thyroglobulin, and may influence the degree of biochemical differentiation and the natural course of the tumors.	Glycogen	58-66	thyroglobulin	Homo sapiens	129-142
826326-0	1976	[Formation of iodotyrosines and iodothyronines in low iodinated human thyroglobulin fractionated by isopycnic ultracentrifugation].	Monoiodotyrosine	14-27	thyroglobulin	Homo sapiens	70-83
831387-4	1977	Increase of the iodine content was associated to the increase of the TG content: mean value was 0.16 mug 127I/100 mug TG in neonates who died within the first 20 hours after birth, 0.25 mug in neonates who survived 26 to 72 hours and 0.43 mug in neonates living more than 10 days.	Iodine	16-22	thyroglobulin	Homo sapiens	69-71
831387-4	1977	Increase of the iodine content was associated to the increase of the TG content: mean value was 0.16 mug 127I/100 mug TG in neonates who died within the first 20 hours after birth, 0.25 mug in neonates who survived 26 to 72 hours and 0.43 mug in neonates living more than 10 days.	Iodine	16-22	thyroglobulin	Homo sapiens	118-120
831387-6	1977	When the iodoamino acids were expressed in residues per molecule of TG, iodtyrosines, thyroxine and triiodothyronine increased with duration of survival.	iodoamino acids	9-24	thyroglobulin	Homo sapiens	68-70
884130-3	1977	In studying the solubility characteristics of thyroglobulin, it was found that the removal of sialic acid residues from either human or hog thyroglobulin by treatment with neuraminidase markedly decreased the solubility in salt solutions.	N-Acetylneuraminic Acid	94-105	thyroglobulin	Homo sapiens	46-59
884130-3	1977	In studying the solubility characteristics of thyroglobulin, it was found that the removal of sialic acid residues from either human or hog thyroglobulin by treatment with neuraminidase markedly decreased the solubility in salt solutions.	N-Acetylneuraminic Acid	94-105	thyroglobulin	Homo sapiens	140-153
884130-4	1977	On the other hand, naturally sialic acid-rich thyroglobulin obtained from human diffuse goiter was slightly more soluble than thyroglobulin in which sialic acid content was within the normal range.	N-Acetylneuraminic Acid	29-40	thyroglobulin	Homo sapiens	46-59
884130-4	1977	On the other hand, naturally sialic acid-rich thyroglobulin obtained from human diffuse goiter was slightly more soluble than thyroglobulin in which sialic acid content was within the normal range.	N-Acetylneuraminic Acid	149-160	thyroglobulin	Homo sapiens	46-59
884130-5	1977	However, the desialized preparations prepared from both normal and sialic acid-rich thyroglobulin showed markedly lower solubility and further, showed no significant difference in solubility between them.	sialic	67-73	thyroglobulin	Homo sapiens	84-97
884130-6	1977	These results indicate that the surface charge of thyroglobulin which influenced the salting-out property depends largely on the number of sialic acid residues in a thyroglobulin molecule, not on the degree of iodination of thyroglobulin.	N-Acetylneuraminic Acid	139-150	thyroglobulin	Homo sapiens	50-63
884130-6	1977	These results indicate that the surface charge of thyroglobulin which influenced the salting-out property depends largely on the number of sialic acid residues in a thyroglobulin molecule, not on the degree of iodination of thyroglobulin.	N-Acetylneuraminic Acid	139-150	thyroglobulin	Homo sapiens	165-178
884130-6	1977	These results indicate that the surface charge of thyroglobulin which influenced the salting-out property depends largely on the number of sialic acid residues in a thyroglobulin molecule, not on the degree of iodination of thyroglobulin.	N-Acetylneuraminic Acid	139-150	thyroglobulin	Homo sapiens	165-178
826326-0	1976	[Formation of iodotyrosines and iodothyronines in low iodinated human thyroglobulin fractionated by isopycnic ultracentrifugation].	iodothyronines	32-46	thyroglobulin	Homo sapiens	70-83
822669-0	1976	Role of galactose in the antigenic properties of thyroglobulin.	Galactose	8-17	thyroglobulin	Homo sapiens	49-62
1009934-0	1976	Maximal number of hormonogenic iodotyrosine residues in thyroglobulin iodinated by thyroid peroxidase.	Monoiodotyrosine	31-43	thyroglobulin	Homo sapiens	56-69
1009934-1	1976	Almost non-iodinated human goiter thyroglobulin has been iodinated in vitro by thyroid peroxidase to levels as high as 75 iodine atoms per mol of protein.	Iodine	122-128	thyroglobulin	Homo sapiens	34-47
1009934-4	1976	The iodine distribution obtained in vitro with human thyroglobulin strongly ressembles that obtained in vivo for rat thyroglobulin.	Iodine	4-10	thyroglobulin	Homo sapiens	53-66
1009934-5	1976	Thus the distribution of iodine seems to depend essentially on the structure of thyroglobulin and on the reactivity of the different tyrosine residues.	Iodine	25-31	thyroglobulin	Homo sapiens	80-93
1009934-10	1976	Maximal thyroxine content was found to be lower than approximately 3 mol/mol of thyroglobulin.	Thyroxine	8-17	thyroglobulin	Homo sapiens	80-93
947903-5	1976	The large oligomannosyl cores (approximately 7 to 8 mannosyl residues) were predominant in the glycopeptides from growing cells and were preferentially associated with neutral glycopeptides, similar to Unit A glycopeptides of thyroglobulin (mannose-N-acetylglucosamine unit).	mannosyl	15-23	thyroglobulin	Homo sapiens	226-239
822669-5	1976	It is thus shown that galactose in the terminal environment of the oligosaccharide chains of thyroglobulin is essential for the structural groups involved in the antigenic properties of thyroglobulin.	Galactose	22-31	thyroglobulin	Homo sapiens	93-106
822669-5	1976	It is thus shown that galactose in the terminal environment of the oligosaccharide chains of thyroglobulin is essential for the structural groups involved in the antigenic properties of thyroglobulin.	Galactose	22-31	thyroglobulin	Homo sapiens	186-199
822669-5	1976	It is thus shown that galactose in the terminal environment of the oligosaccharide chains of thyroglobulin is essential for the structural groups involved in the antigenic properties of thyroglobulin.	Oligosaccharides	67-82	thyroglobulin	Homo sapiens	93-106
822669-5	1976	It is thus shown that galactose in the terminal environment of the oligosaccharide chains of thyroglobulin is essential for the structural groups involved in the antigenic properties of thyroglobulin.	Oligosaccharides	67-82	thyroglobulin	Homo sapiens	186-199
1212459-3	1975	14C-radioactivity of 19S fraction (thyroglobulin) was shown to comprise about 25% of total radioactivity.	Carbon-14	0-3	thyroglobulin	Homo sapiens	35-48
60186-8	1976	The results indicate that sialic acid masks antigenic determinants in human thyroglobulin and that carbohydrates might be the determinants involved in the process of autoimmunization.	N-Acetylneuraminic Acid	26-37	thyroglobulin	Homo sapiens	76-89
964261-1	1976	Isopycnic centrifugation in RbCl was shown to be an effective method both for evaluating the iodine content of thyroglobulin labelled in vivo and for the fractionation of thyroglobulin molecules as a function of their iodine content.	Iodine	93-99	thyroglobulin	Homo sapiens	111-124
964261-3	1976	Based on these methods it was shown that iodination in vivo is a selective process, 19-S and poorly iodinated thyroglobulin having a higher reactivity toward iodine than 27-S and iodine-rich thyroglobulin.	Iodine	158-164	thyroglobulin	Homo sapiens	110-123
964261-8	1976	Among the pool of those newly iodinated thyroid proteins, 27-S molecules were reabsorbed faster than 19-S molecules and iodine-rich thyroglobulin molecules were reabsorbed faster than the iodine-poor ones.	Iodine	120-126	thyroglobulin	Homo sapiens	132-145
1243914-6	1975	The purification of anti-Tg was performed by affinity chromatography using Tg-Sepharose, as an immunoadsorbent.	Sepharose	78-87	thyroglobulin	Homo sapiens	25-27
1243914-6	1975	The purification of anti-Tg was performed by affinity chromatography using Tg-Sepharose, as an immunoadsorbent.	Sepharose	78-87	thyroglobulin	Homo sapiens	75-77
1243914-8	1975	The immunoadsorbent (Tg-Sepharose conjugate) was used in a column procedure for the isolation of anti-Tg from globulin fractions obtained from Hashimoto"s sera.	Sepharose	24-33	thyroglobulin	Homo sapiens	21-23
1243914-8	1975	The immunoadsorbent (Tg-Sepharose conjugate) was used in a column procedure for the isolation of anti-Tg from globulin fractions obtained from Hashimoto"s sera.	Sepharose	24-33	thyroglobulin	Homo sapiens	102-104
1243914-10	1975	The eluted materials contained a very small amount of Tg which was removed by Sephadex G-200 chromatography using the same elution buffer.	sephadex	78-92	thyroglobulin	Homo sapiens	54-56
1243915-18	1975	From these observations, it is concluded that MIF against Tg can easily be detected by the agarose plate technique and that cellular immunity may play a more important role in the initial phase of autoimmune thyroid diseases than the later phase, in which the serum levels of circulating antibodies are becoming predominant.	Sepharose	91-98	thyroglobulin	Homo sapiens	58-60
1201740-2	1975	Human thyroglobulin was purified by combined DEAE-cellulose and affinity chromatography using Sepharose 4B-bound Concanavalin A.	DEAE-Cellulose	45-59	thyroglobulin	Homo sapiens	6-19
1201740-2	1975	Human thyroglobulin was purified by combined DEAE-cellulose and affinity chromatography using Sepharose 4B-bound Concanavalin A.	Sepharose	94-106	thyroglobulin	Homo sapiens	6-19
3147-0	1975	Sialic acid in thyroglobulin.	N-Acetylneuraminic Acid	0-11	thyroglobulin	Homo sapiens	15-28
1159044-9	1975	The incomplete incorporation of carbohydrates into thyroglobulin in the "cold" nodule could be important for the maturation and migration of the molecule to the iodinating site of the cell	Carbohydrates	32-45	thyroglobulin	Homo sapiens	51-64
1212981-1	1975	The effect of excess iodide on hog thyroid gland has been examined with regard to the change in the chemical composition of thyroglobulin and in the accumulation of 27-S iodoprotein by the in vivo treatment of hogs with iodide for various lengths of time.	Iodides	21-27	thyroglobulin	Homo sapiens	124-137
1212981-2	1975	The iodine content of thyroglobulin was either unchanged by short term administration of excess iodide, or somewhat lowered.	Iodine	4-10	thyroglobulin	Homo sapiens	22-35
1212981-2	1975	The iodine content of thyroglobulin was either unchanged by short term administration of excess iodide, or somewhat lowered.	Iodides	96-102	thyroglobulin	Homo sapiens	22-35
1212981-3	1975	However, the iodine content as well as the total amount of thyroglobulin increased in the glands enlarged by prolonged treatment with iodide.	Iodides	134-140	thyroglobulin	Homo sapiens	59-72
1212981-6	1975	Monoiodotyrosine and diiodotyrosine increased in parallel with the increase in the iodine content (0.15 to 1.17%) caused by the iodide treatment, while thyroxine increased but reached a plateau at the level of three residues per mole of thyroglobulin, and no change was observed even in the proteins with the higher iodine content than 0.75%.	Iodides	128-134	thyroglobulin	Homo sapiens	237-250
1212981-8	1975	On the other hand, the amount of iodocompound released by the autoproteolysis, which may reflect hormone secretion, increased, possibly because of the marked increase in the iodine content of thyroglobulin.	Iodine	174-180	thyroglobulin	Homo sapiens	192-205
1190729-3	1975	With high iodide concentrations a highly iodinated thyroglobulin (40-50 iodine atoms) containing no thyroxine was obtained after 3 minutes of incubation.	Iodides	10-16	thyroglobulin	Homo sapiens	51-64
1190729-3	1975	With high iodide concentrations a highly iodinated thyroglobulin (40-50 iodine atoms) containing no thyroxine was obtained after 3 minutes of incubation.	Iodine	72-78	thyroglobulin	Homo sapiens	51-64
1190729-4	1975	If this highly iodinated goiter thyroglobulin was purified and reincubated with peroxidase and H2O2, thyroxine synthesis was again observed only after a lag period (2-3 min).	Hydrogen Peroxide	95-99	thyroglobulin	Homo sapiens	32-45
1190729-4	1975	If this highly iodinated goiter thyroglobulin was purified and reincubated with peroxidase and H2O2, thyroxine synthesis was again observed only after a lag period (2-3 min).	Thyroxine	101-110	thyroglobulin	Homo sapiens	32-45
1190729-6	1975	Depending of its concentration free diiodotyrosine exerts two opposite effects on the reaction catalyzed by thyroid peroxidase : at high concentration (10(-4) M) in inhibition of thyroglobulin iodination, and at low concentration (10(-7), 10(-8) M) a stimulating effect on thyroid hormones biosynthesis.	Diiodotyrosine	36-50	thyroglobulin	Homo sapiens	179-192
3147-3	1975	During electrophoresis in polyacrylamide gel at pH 9-5, it was noticed that sialic acid-poor thyroglobulin contains fewer low molecular weight fragments than sialic acid-rich thyroglobulin.	polyacrylamide	26-40	thyroglobulin	Homo sapiens	93-106
3147-5	1975	This phenomenon was interpreted as a result of lowered hydrophilia of these regions of the thyroglobulin molecule which contains tyrosine and its iodinated derivatives.	Tyrosine	129-137	thyroglobulin	Homo sapiens	91-104
4202122-0	1973	Neutral and amino sugar composition of thyroglobulin.	Amino Sugars	12-23	thyroglobulin	Homo sapiens	39-52
4105295-0	1970	[Degree of iodination and iodoamino acid composition of thyroglobulin in diffuse toxic goiter].	iodoamino acid	26-40	thyroglobulin	Homo sapiens	56-69
4778755-0	1973	Iodine exchange reactions of iodoamino acids and thyroglobulin in in vitro iodinating systems with peroxidases.	Iodine	0-6	thyroglobulin	Homo sapiens	49-62
4408388-0	1974	Thyroglobulin in serum after TSH stimulation in hyperthyroidism.	Thyrotropin	29-32	thyroglobulin	Homo sapiens	0-13
4105306-0	1971	Effect of freezing in methylmercaptoimidazole on the structure of thyroglobulin.	Methimazole	22-45	thyroglobulin	Homo sapiens	66-79
4971602-5	1968	Thyroglobulin molecules dried in sodium tungstosilicate on a carbon film as for electron microscopy retained their hemagglutination-inhibiting activity and 19S sedimentation constant when redissolved in physiological buffer.	Carbon	61-67	thyroglobulin	Homo sapiens	0-13
5435289-0	1970	Thyroglobulin-like substances with low iodine content in the serum of patients receiving antithyroid therapy.	Iodine	39-45	thyroglobulin	Homo sapiens	0-13
5439484-0	1970	Thyroglobulin iodoamino acids estimation after digestion with pronase and leucylaminopeptidase.	iodoamino acids	14-29	thyroglobulin	Homo sapiens	0-13
5917084-1	1966	Crystals of thyroglobulin have been obtained from ammonium sulfate solutions and have been examined by electron microscopy as shadowed carbon replicas.	Ammonium Sulfate	50-66	thyroglobulin	Homo sapiens	12-25
5694391-0	1968	Thyroglobulin-iodine in thyroid tumors.	Iodine	14-20	thyroglobulin	Homo sapiens	0-13
4880352-10	1968	Peptic hydrolysis of thyroglobulin releases virtually all of the iodothyronines but little of the iodotyrosines, in contrast with the action of pancreatin.	iodothyronines	65-79	thyroglobulin	Homo sapiens	21-34
4880352-10	1968	Peptic hydrolysis of thyroglobulin releases virtually all of the iodothyronines but little of the iodotyrosines, in contrast with the action of pancreatin.	Monoiodotyrosine	98-111	thyroglobulin	Homo sapiens	21-34
5917084-1	1966	Crystals of thyroglobulin have been obtained from ammonium sulfate solutions and have been examined by electron microscopy as shadowed carbon replicas.	Carbon	135-141	thyroglobulin	Homo sapiens	12-25
13198940-0	1954	Mucopolysaccharides bound to thyroglobulin; a histochemical and paper-electrophoretic investigation.	Glycosaminoglycans	0-19	thyroglobulin	Homo sapiens	29-42
4958529-0	1966	[In vitro metabolism of D-1-C14-glucosamine in the thyroid gland and biosynthesis of thyroglobulin].	d-1-c14-glucosamine	24-43	thyroglobulin	Homo sapiens	85-98
13527456-0	1957	[Localization of labeled thyroglobulin in thyroid structures in various periods after administration of radioiodine].	Iodine-131	104-115	thyroglobulin	Homo sapiens	25-38
5844217-1	1965	Experiments are described in which tanned red cells coated with a globulin fraction of human serum with a high titre of antibody to human thyroglobulin were agglutinated by saline extracts of human thyroid gland and thyroglobulin but not by other tissue extracts.	Sodium Chloride	173-179	thyroglobulin	Homo sapiens	138-151
14265528-0	1965	[CURRENT SUCCESSES OF THE PREVENTIVE IODINE TREATMENT OF ENDEMIC GOITER IN A GOITER REGION OF SLOVAKIA AND THE IMPROVEMENT OF GOITER CASES WITH THE USE OF THYROGLOBULIN].	Iodine	37-43	thyroglobulin	Homo sapiens	155-168
13488561-0	1957	[Effect of thyroglobulin and thyroxin on thyroid fixation of radioiodine].	Iodine-131	61-72	thyroglobulin	Homo sapiens	11-24
34040584-0	2021	Predictive Value of Thyroglobulin Changes for the Curative Effect of Radioiodine Therapy in Patients With Metastatic Differentiated Thyroid Carcinoma.	Iodine-131	69-80	thyroglobulin	Homo sapiens	20-33
14903690-0	1952	[Radioiodine labelled human thyroglobulin in the normal state and in Basedow"s disease].	Iodine-131	1-12	thyroglobulin	Homo sapiens	28-41
34014437-12	2021	CONCLUSIONS: Tg kinetics may help to predict 2-[18F]-FDG-PET/CT results in DTC patients with negative [131I]WBS and detectable Tg, especially in case of low-moderate Tg.	Fluorodeoxyglucose F18	53-56	thyroglobulin	Homo sapiens	13-15
13341056-0	1956	The effects of iodine on the ultraviolet absorbance spectra of thyroglobulin, casein and insulin.	Iodine	15-21	thyroglobulin	Homo sapiens	63-76
34042535-0	2021	Biotin Interference in Assays for Thyroid Hormones, Thyrotropin and Thyroglobulin.	Biotin	0-6	thyroglobulin	Homo sapiens	68-81
33716951-0	2020	Utility of Stimulated Thyroglobulin in Reclassifying Low Risk Thyroid Cancer Patients" Following Thyroidectomy and Radioactive Iodine Ablation: A 7-Year Prospective Trial.	radioactive iodine	115-133	thyroglobulin	Homo sapiens	22-35
33926848-6	2021	According to the 2015 American Thyroid Association guidelines, 18F-FDG PET/CT is recommended in the follow-up of high-risk patients with elevated serum thyroglobulin and negative 131I imaging, in the assessment of metastatic patients, for lesion detection and risk stratification and in predicting the response to therapy.	Fluorodeoxyglucose F18	63-70	thyroglobulin	Homo sapiens	152-165
34028418-2	2022	After 4 weeks of L-thyroxine withdrawal, stimulated serum thyroglobulin level was less than 0.1 ng/mL with positive thyroglobulin antibody.	Thyroxine	17-28	thyroglobulin	Homo sapiens	58-71
34028418-2	2022	After 4 weeks of L-thyroxine withdrawal, stimulated serum thyroglobulin level was less than 0.1 ng/mL with positive thyroglobulin antibody.	Thyroxine	17-28	thyroglobulin	Homo sapiens	116-129
33650064-1	2022	The current study aimed to identify correlative and regressive dependencies between the water iodine concentration and the levels of TSH (thyroid-stimulating hormone), thyroglobulin antibodies (TgAbs), and thyroid peroxidase (TPOAb) in the serum of 168 in patients (34 men and 134 women) with a hypothyroid form of Hashimoto"s thyroiditis who use water from the supply network and individual wells.	Water	88-93	thyroglobulin	Homo sapiens	168-181
33716951-1	2020	Context: Following total thyroidectomy and radioactive iodine (RAI) ablation, serum thyroglobulin levels should be undetectable to assure that patients are excellent responders and at very low risk of recurrence.	radioactive iodine	43-61	thyroglobulin	Homo sapiens	84-97
33716951-1	2020	Context: Following total thyroidectomy and radioactive iodine (RAI) ablation, serum thyroglobulin levels should be undetectable to assure that patients are excellent responders and at very low risk of recurrence.	Insulin, Short-Acting	63-66	thyroglobulin	Homo sapiens	84-97
33505608-1	2020	The purpose of the present study is to examine the diagnostic and predictive accuracy of the thyroglobulin (Tg) to thyroid stimulating hormone (TSH) and TSH/Tg ratios in normothyroid patients with differentiated thyroid cancer (DTC).	Thyrotropin	144-147	thyroglobulin	Homo sapiens	93-106
32794104-0	2021	Thyroglobulin doubling time offers a better threshold than thyroglobulin level for selecting optimal candidates to undergo localizing [18F]FDG PET/CT in non-iodine avid differentiated thyroid carcinoma.	Iodine	157-163	thyroglobulin	Homo sapiens	0-13
32794104-1	2021	PURPOSE: To investigate the potential role of serum thyroglobulin doubling time (TgDT) in predicting 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) PET/CT results in patients affected by differentiated thyroid carcinoma (DTC) who demonstrated a combination of positive Tg but a negative [131I] whole-body scan ([131I]-WBS).	Glucose	125-132	thyroglobulin	Homo sapiens	52-65
32713865-6	2020	The three patients had falsely elevated serum PTH and thyroglobulin levels owing to heterophile antibody interference associated with NK cell therapy that persisted for at least up to 12 months after the treatment and was confirmed by normalization of hormone levels after HBT treatment.	hbt	273-276	thyroglobulin	Homo sapiens	54-67
33581410-1	2021	Thyroglobulin (Tg) is a secreted iodoglycoprotein serving as the precursor for triiodothyronine and thyroxine hormones.	Triiodothyronine	79-95	thyroglobulin	Homo sapiens	0-13
33581410-1	2021	Thyroglobulin (Tg) is a secreted iodoglycoprotein serving as the precursor for triiodothyronine and thyroxine hormones.	Triiodothyronine	79-95	thyroglobulin	Homo sapiens	15-17
33581410-1	2021	Thyroglobulin (Tg) is a secreted iodoglycoprotein serving as the precursor for triiodothyronine and thyroxine hormones.	Thyroxine	100-109	thyroglobulin	Homo sapiens	0-13
33581410-1	2021	Thyroglobulin (Tg) is a secreted iodoglycoprotein serving as the precursor for triiodothyronine and thyroxine hormones.	Thyroxine	100-109	thyroglobulin	Homo sapiens	15-17
33581410-7	2021	Furthermore, we reveal mutation-specific changes in engagement with N-glycosylation components, suggesting distinct requirements for 1 Tg variant on dual engagement of both oligosaccharyltransferase complex isoforms for degradation.	Nitrogen	68-69	thyroglobulin	Homo sapiens	135-137
32935188-0	2020	18F-FDG-PET/CT indication in patients affected by differentiated thyroid cancer with elevated serum thyroglobulin and negative whole-body scanning after therapy with 131I.	Fluorodeoxyglucose F18	0-7	thyroglobulin	Homo sapiens	100-113
32601803-1	2020	AIMS: 18F-FDG PET/CT is the most accurate imaging modality in differentiated thyroid cancer (DTC) patients with either an aggressive histology, an absence of radioiodine uptake in neoplastic foci, or in the absence of imaging abnormalities in patients with an elevated serum thyroglobulin (Tg) level that progresses with time.	Fluorodeoxyglucose F18	6-13	thyroglobulin	Homo sapiens	275-288
32183608-12	2020	Maternal MMN supplement increased maternal UIC (p<0 001), decreased maternal Tg (p<0 001) and cord blood Tg (p<0.001) compared with FeFol.	2-deoxy-2-acetamido-mannitol	9-12	thyroglobulin	Homo sapiens	77-79
31352718-0	2020	The clinical meaning of pre- and post-ablation thyroglobulin levels at first radioiodine therapy in patients with papillary thyroid cancer.	Iodine-131	77-88	thyroglobulin	Homo sapiens	47-60
32538690-0	2020	An International Phase 2 Study of Pazopanib in Progressive and Metastatic Thyroglobulin Antibody Negative Radioactive Iodine Refractory Differentiated Thyroid Cancer.	pazopanib	34-43	thyroglobulin	Homo sapiens	74-87
32538690-0	2020	An International Phase 2 Study of Pazopanib in Progressive and Metastatic Thyroglobulin Antibody Negative Radioactive Iodine Refractory Differentiated Thyroid Cancer.	radioactive iodine	106-124	thyroglobulin	Homo sapiens	74-87
33025094-0	2020	Response to the letter to the editor "18F-FDG-PET/CT indication in patients affected by differentiated thyroid cancer with elevated serum thyroglobulin and negative whole-body scanning after therapy with 131I".	Fluorodeoxyglucose F18	38-45	thyroglobulin	Homo sapiens	138-151
32484287-9	2020	In women with normal prolactin levels, levothyroxine reduced also thyroglobulin antibody titers and increased 25-hydroxyvitamin D levels.	Thyroxine	39-52	thyroglobulin	Homo sapiens	66-79
32183608-12	2020	Maternal MMN supplement increased maternal UIC (p<0 001), decreased maternal Tg (p<0 001) and cord blood Tg (p<0.001) compared with FeFol.	2-deoxy-2-acetamido-mannitol	9-12	thyroglobulin	Homo sapiens	105-107
32183608-14	2020	CONCLUSION: Supplementing moderately iodine deficient women during pregnancy improved maternal iodine status and reduced Tg concentration.	Iodine	37-43	thyroglobulin	Homo sapiens	121-123
32576048-4	2020	Thyroglobulin is used as a biomarker in the long-term surveillance of patients with differentiated thyroid cancer, following total thyroidectomy and radioactive iodine ablation.	radioactive iodine	149-167	thyroglobulin	Homo sapiens	0-13
33082675-1	2020	Purpose of the Study: 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is used in the management of recurrent differentiated thyroid cancer (DTC) patients presented with rising thyroglobulin (Tg) or anti-Tg antibody (Atg) levels and negative whole-body I-131 scan (WBS).	Fluorodeoxyglucose F18	22-44	thyroglobulin	Homo sapiens	217-230
33082675-1	2020	Purpose of the Study: 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is used in the management of recurrent differentiated thyroid cancer (DTC) patients presented with rising thyroglobulin (Tg) or anti-Tg antibody (Atg) levels and negative whole-body I-131 scan (WBS).	Fluorodeoxyglucose F18	95-102	thyroglobulin	Homo sapiens	217-230
33354174-0	2020	Clinical efficacy of 177Lu-DOTATATE peptide receptor radionuclide therapy in thyroglobulin-elevated negative iodine scintigraphy: A "not-so-promising" result compared to GEP-NETs.	Iodine	109-115	thyroglobulin	Homo sapiens	77-90
33354174-1	2020	This study aimed at assessing the performance of 177Lu-DOTATATE-based peptide receptor radionuclide therapy (PRRT) in de-differentiated thyroid carcinoma thyroglobulin-elevated negative iodine scintigraphy (TENIS) in terms of clinical efficacy and outcome.	Iodine	186-192	thyroglobulin	Homo sapiens	154-167
31868128-1	2020	The thyroglobulin (TG) gene encodes a protein required for thyroid hormone synthesis and iodine storage.	Iodine	89-95	thyroglobulin	Homo sapiens	4-17
32219303-1	2020	BACKGROUND: The use of thyroglobuin (Tg) and thyroglobulin antibodies (TgAb) for detecting disease recurrence is well validated following total-thyroidectomy and radioiodine.	Iodine-131	162-173	thyroglobulin	Homo sapiens	45-58
32379488-0	2021	Role of Thyroglobulin Doubling Time in Differentiated Thyroid Cancer and Its Relationship with Demographic-Histopathologic Risk Factors and 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Parameters.	Fluorodeoxyglucose F18	140-162	thyroglobulin	Homo sapiens	8-21
32379488-1	2021	Background: Aim of this study was to investigate the relationship between thyroglobulin doubling time (TgDT) and basal risk factors and metabolic parameters derived from 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in differentiated thyroid cancer (DTC).	Fluorodeoxyglucose F18	170-192	thyroglobulin	Homo sapiens	74-87
32379488-1	2021	Background: Aim of this study was to investigate the relationship between thyroglobulin doubling time (TgDT) and basal risk factors and metabolic parameters derived from 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in differentiated thyroid cancer (DTC).	Fluorodeoxyglucose F18	194-197	thyroglobulin	Homo sapiens	74-87
32581401-9	2020	Patients with metastatic RAI accumulation showed a significantly higher frequency of pathological N1 (pN1) and serum thyroglobulin (Tg) > 1.5 ng/ml under TSH stimulation (p = 0.035 and p = 0.031, respectively).	Thyrotropin	154-157	thyroglobulin	Homo sapiens	117-130
32357947-5	2020	The present study clearly shows iodine deficiency in a group of 2nd trimester women as judged by measurement of serum thyroglobulin (a recently evaluated marker of iodine deficiency).	Iodine	32-38	thyroglobulin	Homo sapiens	118-131
32357947-5	2020	The present study clearly shows iodine deficiency in a group of 2nd trimester women as judged by measurement of serum thyroglobulin (a recently evaluated marker of iodine deficiency).	Iodine	164-170	thyroglobulin	Homo sapiens	118-131
31868128-1	2020	The thyroglobulin (TG) gene encodes a protein required for thyroid hormone synthesis and iodine storage.	Iodine	89-95	thyroglobulin	Homo sapiens	19-21
31910106-1	2020	Background: Literature to date has been inconclusive regarding the value of thyroglobulin (Tg) as a marker of iodine status in pregnant women.	Iodine	110-116	thyroglobulin	Homo sapiens	76-89
31910106-2	2020	This systematic review and meta-analysis is one of the first to assess whether Tg concentration accurately reflects iodine status among pregnant women.	Iodine	116-122	thyroglobulin	Homo sapiens	79-81
31910106-10	2020	The pooled mean (95% confidence interval [CI]) Tg concentration in iodine-deficient pregnant women was higher than that in iodine-sufficient pregnant women (10.73 mug/L [5.65-15.82] vs. 7.34 mug/L [2.20-12.47]); a comparison of the 95% CI showed that none of these values was significantly different.	Iodine	67-73	thyroglobulin	Homo sapiens	47-49
32032192-0	2020	Early detection of progressive disease using thyroglobulin doubling-time in metastatic differentiated thyroid carcinoma treated with radioactive iodine.	radioactive iodine	133-151	thyroglobulin	Homo sapiens	45-58
31865556-0	2020	Role of adjuvant therapy with radioactive iodine in patients with elevated serum thyroglobulin after neck reoperation due to recurrent papillary thyroid cancer: a monoinstitutional comparative study.	radioactive iodine	30-48	thyroglobulin	Homo sapiens	81-94
32243397-1	2020	Although serum thyroglobulin (Tg) is a reliable differentiated thyroid carcinoma (DTC) prognostic marker, its cutoff values can be affected by TSH stimulation status.	Thyrotropin	143-146	thyroglobulin	Homo sapiens	15-28
32990621-9	2020	After adjusting for age and gender, the association between thyroglobulin antibody and urinary iodine concentration was significant (beta: 0.002; p<0.05).	Iodine	95-101	thyroglobulin	Homo sapiens	60-73
31978980-0	2020	Optimization of Predictive Performance for the Therapeutic Response Using Iodine Scan-Corrected Serum Thyroglobulin in Patients with Differentiated Thyroid Carcinoma.	Iodine	74-80	thyroglobulin	Homo sapiens	102-115
32229438-1	2020	BACKGROUND AND OBJECTIVES: Thyroglobulin (Tg) is considered a sensitive indicator of iodine status for children and adults, but its usefulness for pregnant women is unknown.	Iodine	85-91	thyroglobulin	Homo sapiens	27-40
32092093-9	2020	Univariate analysis showed that tumor size >4 cm, presence of atypical mitoses, Ki-67 >5%, and thyroglobulin (Tg)-negative immunostaining were associated with a higher risk of PDTC-related death.	prolinedithiocarbamate	176-180	thyroglobulin	Homo sapiens	95-108
32229438-1	2020	BACKGROUND AND OBJECTIVES: Thyroglobulin (Tg) is considered a sensitive indicator of iodine status for children and adults, but its usefulness for pregnant women is unknown.	Iodine	85-91	thyroglobulin	Homo sapiens	42-44
32990621-11	2020	CONCLUSIONS: Excessive iodine in patients with thyroid tumors may affect thyroglobulin antibody, which may be an independent risk factor for papillary thyroid cancer.	Iodine	23-29	thyroglobulin	Homo sapiens	73-86
32229438-2	2020	The aim of this study was attempting to explore the relationship between Tg and iodine status and the association between elevated Tg and thyroid diseases.	Iodine	80-86	thyroglobulin	Homo sapiens	73-75
32163693-3	2020	In this regard, it was interesting for us to determine the possible effect of dopamine at its various concentrations in the blood on the levels of thyroglobulin and antibodies to thyroid antigens.	Dopamine	78-86	thyroglobulin	Homo sapiens	147-160
32229438-11	2020	Tg can be a functional biomarker of iodine deficient, thyroid nodules and goiter.	Iodine	36-42	thyroglobulin	Homo sapiens	0-2
32163693-6	2020	Higher concentrations of thyrotropin and thyroglobulin and lower concentrations of at-TG and at-TPO were shown with increasing dopamine levels from undetectable values to normative and excess levels.	Dopamine	127-135	thyroglobulin	Homo sapiens	41-54
31444962-1	2019	Background Differentiated thyroid carcinoma (DTC) has an excellent prognosis and the role of high-sensitive thyroglobulin measured during levothyroxine (ON-T4 hs-Tg) testing to discriminate patients with structural from not-evidence of disease (SED and NED, respectively) has been investigated.	Thyroxine	138-151	thyroglobulin	Homo sapiens	108-121
31782421-1	2019	We have developed new benign palladium nanoparticles able to catalyze the Suzuki-Miyaura cross-coupling reaction on human thyroglobulin (Tg), a naturally iodinated protein produced by the thyroid gland, in homogenates from patients" tissues.	Palladium	29-38	thyroglobulin	Homo sapiens	122-135
31444962-1	2019	Background Differentiated thyroid carcinoma (DTC) has an excellent prognosis and the role of high-sensitive thyroglobulin measured during levothyroxine (ON-T4 hs-Tg) testing to discriminate patients with structural from not-evidence of disease (SED and NED, respectively) has been investigated.	on-t4 hs-tg	153-164	thyroglobulin	Homo sapiens	108-121
31558473-8	2019	Thyroglobulin decrease >=30% from baseline was achieved by 76% and 14% of patients receiving sorafenib and placebo, respectively (P < 0.001).	Sorafenib	93-102	thyroglobulin	Homo sapiens	0-13
31558473-9	2019	Patients with >=30% thyroglobulin reduction had longer PFS than those without >=30% reduction [HR (95% CI): sorafenib = 0.61 (0.40-0.94), P = 0.022; placebo = 0.49 (0.29-0.85), P = 0.009].	Sorafenib	108-117	thyroglobulin	Homo sapiens	20-33
31861014-0	2019	Can the basal serum thyroglobulin level be used to predict the recombinant human TSH-stimulated thyroglobulin level in differentiated patients with thyroid cancer?	Thyrotropin	81-84	thyroglobulin	Homo sapiens	20-33
31546407-2	2019	We report a novel design to prepare molecular imprinting polymers (MIPs) on the surface of hemin-graphene nanosheets (H-GNs) for the recognition of thyroglobulin (Tg, 660 KD).	Graphite	91-105	thyroglobulin	Homo sapiens	148-161
31407180-0	2019	Postoperative Unstimulated Thyroglobulin for the Decision to Use Radioactive Iodine in Patients with Low- or Intermediate-Risk Papillary Thyroid Carcinoma.	radioactive iodine	65-83	thyroglobulin	Homo sapiens	27-40
31463692-0	2019	Reply to: Postoperative Unstimulated Thyroglobulin for the Decision to Use Radioactive Iodine in Patients with Low- or Intermediate-Risk Papillary Thyroid Carcinoma.	radioactive iodine	75-93	thyroglobulin	Homo sapiens	37-50
31861014-0	2019	Can the basal serum thyroglobulin level be used to predict the recombinant human TSH-stimulated thyroglobulin level in differentiated patients with thyroid cancer?	Thyrotropin	81-84	thyroglobulin	Homo sapiens	96-109
31484161-8	2019	In patients with detectable serum Tg or detectable Tg antibodies, the trend over time of these markers on levothyroxine treatment will dictate subsequent follow-up: a decreasing trend is reassuring, but an increasing trend should lead to imaging, starting with neck ultrasonography.	Thyroxine	106-119	thyroglobulin	Homo sapiens	34-36
31689890-0	2019	The Effects of Iodine Supplementation in Pregnancy on Iodine Status, Thyroglobulin Levels and Thyroid Function Parameters: Results from a Randomized Controlled Clinical Trial in a Mild-to-Moderate Iodine Deficiency Area.	Iodine	15-21	thyroglobulin	Homo sapiens	69-82
31454572-4	2019	Some compounds of PCBs, PBDEs, and NFRs showed strong binding affinity to the thyroid-stimulating hormone (TSH), thyroglobulin, thyroxine-binding globulin (TBG), gene expression of TH receptor alpha (TRalpha) and beta, and iodothyronine deiodinase I (ID1).	Polychlorinated Biphenyls	18-22	thyroglobulin	Homo sapiens	113-126
31454572-4	2019	Some compounds of PCBs, PBDEs, and NFRs showed strong binding affinity to the thyroid-stimulating hormone (TSH), thyroglobulin, thyroxine-binding globulin (TBG), gene expression of TH receptor alpha (TRalpha) and beta, and iodothyronine deiodinase I (ID1).	Halogenated Diphenyl Ethers	24-29	thyroglobulin	Homo sapiens	113-126
31317522-5	2019	Patient response to radioactive iodine (RAI) therapy was monitored by changes in serum thyroglobulin levels and imaging changes.	radioactive iodine	20-38	thyroglobulin	Homo sapiens	87-100
31317522-5	2019	Patient response to radioactive iodine (RAI) therapy was monitored by changes in serum thyroglobulin levels and imaging changes.	Insulin, Short-Acting	40-43	thyroglobulin	Homo sapiens	87-100
31484161-8	2019	In patients with detectable serum Tg or detectable Tg antibodies, the trend over time of these markers on levothyroxine treatment will dictate subsequent follow-up: a decreasing trend is reassuring, but an increasing trend should lead to imaging, starting with neck ultrasonography.	Thyroxine	106-119	thyroglobulin	Homo sapiens	51-53
29557257-4	2019	These techniques were used to model the relationship between thyroglobulin levels in individuals with differentiated thyroid cancer before and after treatment with radioactive iodine (I-131).	radioactive iodine	164-182	thyroglobulin	Homo sapiens	61-74
31525728-11	2019	Our results revealed that the thyroid Tregs was a distinct population of Tregs, which expressed high level of Tg.	tregs	38-43	thyroglobulin	Homo sapiens	110-112
31106856-7	2019	Although selenomethionine reduced thyroid peroxidase and thyroglobulin antibody titers in both treatment arms, these effects were stronger in testosterone-treated than in testosterone-untreated men.	Selenomethionine	9-25	thyroglobulin	Homo sapiens	57-70
31327159-5	2019	UM were diagnosed by: (i) biopsy/cytology and/or (ii) radioiodine (RAI) uptake associated to elevated thyroglobulin (Tg) levels and/or c) presence of one or more structural lesion/s with 18-FDG uptake in the PET/CT scan and elevated Tg levels.	Iodine-131	54-65	thyroglobulin	Homo sapiens	102-115
31327159-5	2019	UM were diagnosed by: (i) biopsy/cytology and/or (ii) radioiodine (RAI) uptake associated to elevated thyroglobulin (Tg) levels and/or c) presence of one or more structural lesion/s with 18-FDG uptake in the PET/CT scan and elevated Tg levels.	Iodine-131	67-70	thyroglobulin	Homo sapiens	102-115
31425569-5	2019	OBJECTIVE: The aim of this study was to determine the factors that influence long-term disease-specific survival and thyroglobulin levels in patients with DTC who have been previously treated with thyroidectomy and radioactive iodine (RAI) remnant ablation.	radioactive iodine	215-233	thyroglobulin	Homo sapiens	117-130
31425569-5	2019	OBJECTIVE: The aim of this study was to determine the factors that influence long-term disease-specific survival and thyroglobulin levels in patients with DTC who have been previously treated with thyroidectomy and radioactive iodine (RAI) remnant ablation.	Insulin, Short-Acting	235-238	thyroglobulin	Homo sapiens	117-130
31168052-0	2019	Author Correction: Effects of exogenous melatonin on clinical and pathological features of a human thyroglobulin-induced experimental autoimmune thyroiditis mouse model.	Melatonin	40-49	thyroglobulin	Homo sapiens	99-112
30971749-0	2019	Effects of exogenous melatonin on clinical and pathological features of a human thyroglobulin-induced experimental autoimmune thyroiditis mouse model.	Melatonin	21-30	thyroglobulin	Homo sapiens	80-93
30886364-3	2019	Upon thyroglobulin delivery from thyrocytes to the follicular lumen of the thyroid gland via the secretory pathway, multiple tyrosine residues can become iodinated to form mono-iodotyrosine (MIT) and/or di-iodotyrosine (DIT); however, selective tyrosine residues lead to preferential formation of T4 and T3 at distinct sites.	Tyrosine	125-133	thyroglobulin	Homo sapiens	5-18
30886364-3	2019	Upon thyroglobulin delivery from thyrocytes to the follicular lumen of the thyroid gland via the secretory pathway, multiple tyrosine residues can become iodinated to form mono-iodotyrosine (MIT) and/or di-iodotyrosine (DIT); however, selective tyrosine residues lead to preferential formation of T4 and T3 at distinct sites.	Monoiodotyrosine	172-189	thyroglobulin	Homo sapiens	5-18
30886364-3	2019	Upon thyroglobulin delivery from thyrocytes to the follicular lumen of the thyroid gland via the secretory pathway, multiple tyrosine residues can become iodinated to form mono-iodotyrosine (MIT) and/or di-iodotyrosine (DIT); however, selective tyrosine residues lead to preferential formation of T4 and T3 at distinct sites.	Monoiodotyrosine	191-194	thyroglobulin	Homo sapiens	5-18
30886364-3	2019	Upon thyroglobulin delivery from thyrocytes to the follicular lumen of the thyroid gland via the secretory pathway, multiple tyrosine residues can become iodinated to form mono-iodotyrosine (MIT) and/or di-iodotyrosine (DIT); however, selective tyrosine residues lead to preferential formation of T4 and T3 at distinct sites.	Diiodotyrosine	203-218	thyroglobulin	Homo sapiens	5-18
30886364-3	2019	Upon thyroglobulin delivery from thyrocytes to the follicular lumen of the thyroid gland via the secretory pathway, multiple tyrosine residues can become iodinated to form mono-iodotyrosine (MIT) and/or di-iodotyrosine (DIT); however, selective tyrosine residues lead to preferential formation of T4 and T3 at distinct sites.	Diiodotyrosine	220-223	thyroglobulin	Homo sapiens	5-18
30886364-3	2019	Upon thyroglobulin delivery from thyrocytes to the follicular lumen of the thyroid gland via the secretory pathway, multiple tyrosine residues can become iodinated to form mono-iodotyrosine (MIT) and/or di-iodotyrosine (DIT); however, selective tyrosine residues lead to preferential formation of T4 and T3 at distinct sites.	Tyrosine	181-189	thyroglobulin	Homo sapiens	5-18
30884464-4	2019	Oral administration of lenvatinib, a multi-target tyrosine kinase inhibitor, reduced the size of cervical and thoracic tumors and lowered serum thyroglobulin levels.	lenvatinib	23-33	thyroglobulin	Homo sapiens	144-157
30566234-3	2019	However, unlike the female bias in human thyroid autoimmunity, autoantibodies to thyroglobulin (TgAb) are reported to be similar in male and female NOD.H2h4 .	h2h4	152-156	thyroglobulin	Homo sapiens	81-94
30930852-0	2019	Outcome of Patients With Differentiated Thyroid Cancer Treated With 131-Iodine on the Basis of a Detectable Serum Thyroglobulin Level After Initial Treatment.	Iodine-131	68-78	thyroglobulin	Homo sapiens	114-127
30930852-1	2019	Background: In patients with differentiated thyroid cancer (DTC) and raising serum thyroglobulin (Tg) after total or near-total thyroidectomy and 131I remnant ablation an empiric 131I therapy may be considered.	Iodine-131	179-183	thyroglobulin	Homo sapiens	83-96
30648484-0	2019	Thyroglobulin Is Markedly Elevated in 6- to 24-Month-Old Infants at Both Low and High Iodine Intakes and Suggests a Narrow Optimal Iodine Intake Range.	Iodine	86-92	thyroglobulin	Homo sapiens	0-13
31363334-4	2019	Decision on postoperative I-131 ablation was based on tumor characteristics, postoperative thyroglobulin level, preablative whole body scintigraphy, and/or neck ultrasound.	Iodine-131	26-31	thyroglobulin	Homo sapiens	91-104
30454940-1	2019	AIMS: Recently published international guidelines recommended using the stimulated thyroglobulin (sTg) post-radioactive iodine (RAI) ablation, in conjunction with tumour stage, as a risk stratification factor.	radioactive iodine	108-126	thyroglobulin	Homo sapiens	83-96
30454940-1	2019	AIMS: Recently published international guidelines recommended using the stimulated thyroglobulin (sTg) post-radioactive iodine (RAI) ablation, in conjunction with tumour stage, as a risk stratification factor.	Insulin, Short-Acting	128-131	thyroglobulin	Homo sapiens	83-96
30208979-5	2019	Iodine: chronic exposure to excess iodine intake induces autoimmune thyroiditis, partly because highly-iodinated thyroglobulin (Tg) is more immunogenic.	Iodine	0-6	thyroglobulin	Homo sapiens	113-126
30208979-5	2019	Iodine: chronic exposure to excess iodine intake induces autoimmune thyroiditis, partly because highly-iodinated thyroglobulin (Tg) is more immunogenic.	Iodine	35-41	thyroglobulin	Homo sapiens	113-126
30382500-0	2019	An enhanced treatment effect can be expected from a higher serum thyroglobulin level after radioactive iodine therapy.	Iodine	103-109	thyroglobulin	Homo sapiens	65-78
30382500-1	2019	OBJECTIVE: The aim of this study was to investigate if increased serum thyroglobulin (Tg) levels after radioactive iodine (RAI) showed more therapeutic effects in patients with differentiated thyroid cancer (DTC).	radioactive iodine	103-121	thyroglobulin	Homo sapiens	71-84
30648484-0	2019	Thyroglobulin Is Markedly Elevated in 6- to 24-Month-Old Infants at Both Low and High Iodine Intakes and Suggests a Narrow Optimal Iodine Intake Range.	Iodine	131-137	thyroglobulin	Homo sapiens	0-13
30648484-3	2019	Thyroglobulin (Tg) is a sensitive marker of iodine intake in school-age children and adults and may be used to estimate the optimal iodine intake range in infancy.	Iodine	44-50	thyroglobulin	Homo sapiens	0-13
30648484-3	2019	Thyroglobulin (Tg) is a sensitive marker of iodine intake in school-age children and adults and may be used to estimate the optimal iodine intake range in infancy.	Iodine	132-138	thyroglobulin	Homo sapiens	0-13
30325815-1	2018	PET using the radiotracer F-fluorodeoxyglucose (FDG) was performed in a patient who presented with elevated thyroglobulin (Tg) levels several years after initial therapy of follicular thyroid carcinoma (oncocytic variant) and in whom high-dose radioiodine (I) failed to locate recurrent tumor or to decrease Tg levels.	f-fluorodeoxyglucose	26-46	thyroglobulin	Homo sapiens	108-121
32008523-1	2019	BACKGROUND: The detection of recurrence or metastasis might be challenging in patients, who underwent total thyroidectomy and radioactive iodine therapy for Differentiated Thyroid Carcinoma (DTC), with increased serum Thyroglobulin (Tg) levels and negative 131I whole body scan (131I-WBS) results.	radioactive iodine	126-144	thyroglobulin	Homo sapiens	218-231
30560716-0	2019	Radioiodine Uptake and Thyroglobulin-Guided Radioiodine Remnant Ablation in Patients with Differentiated Thyroid Cancer: A Prospective, Randomized, Open-Label, Controlled Trial.	Iodine-131	44-55	thyroglobulin	Homo sapiens	23-36
30325815-1	2018	PET using the radiotracer F-fluorodeoxyglucose (FDG) was performed in a patient who presented with elevated thyroglobulin (Tg) levels several years after initial therapy of follicular thyroid carcinoma (oncocytic variant) and in whom high-dose radioiodine (I) failed to locate recurrent tumor or to decrease Tg levels.	fluorescein-digalactoside	48-51	thyroglobulin	Homo sapiens	108-121
30416522-0	2018	Palmitic Acid Downregulates Thyroglobulin (Tg), Sodium Iodide Symporter (NIS), and Thyroperoxidase (TPO) in Human Primary Thyrocytes: A Potential Mechanism by Which Lipotoxicity Affects Thyroid?	Palmitic Acid	0-13	thyroglobulin	Homo sapiens	28-41
30416522-8	2018	Both the mRNA and protein levels of thyroglobulin, sodium iodide symporter, and thyroperoxidase were decreased following palmitic acid stimulation.	Palmitic Acid	121-134	thyroglobulin	Homo sapiens	36-49
30416522-9	2018	Consistently, upon palmitic acid stimulation, the secreted thyroglobulin levels in supernatants, 131I uptake, and extracellular thyroperoxidase activity were all decreased in a dose-dependent manner.	Palmitic Acid	19-32	thyroglobulin	Homo sapiens	59-72
30227620-4	2018	Thyroglobulin (Tg), the protein backbone for synthesis of thyroid hormones, is a heavily N-glycosylated protein, containing 20 putative N-glycosylated sites.	Nitrogen	89-90	thyroglobulin	Homo sapiens	0-13
30416522-10	2018	Our results demonstrated that upon palmitic acid stimulation, the expressions of the key molecules (thyroglobulin, sodium iodide symporter, and thyroperoxidase) were reduced and their activities were suppressed, which might lead to impaired thyroid hormone synthesis.	Palmitic Acid	35-48	thyroglobulin	Homo sapiens	100-113
30386048-2	2018	Clinicians are faced with therapeutic challenges when dealing with patients having thyroglobulin-elevated negative iodine scintigraphy (TENIS) syndrome (elevated serum thyroglobulin [Tg] levels but negative whole-body scans [WBSs]).	Iodine	115-121	thyroglobulin	Homo sapiens	83-96
30227620-4	2018	Thyroglobulin (Tg), the protein backbone for synthesis of thyroid hormones, is a heavily N-glycosylated protein, containing 20 putative N-glycosylated sites.	Nitrogen	89-90	thyroglobulin	Homo sapiens	15-17
30227620-4	2018	Thyroglobulin (Tg), the protein backbone for synthesis of thyroid hormones, is a heavily N-glycosylated protein, containing 20 putative N-glycosylated sites.	Nitrogen	136-137	thyroglobulin	Homo sapiens	0-13
30227620-4	2018	Thyroglobulin (Tg), the protein backbone for synthesis of thyroid hormones, is a heavily N-glycosylated protein, containing 20 putative N-glycosylated sites.	Nitrogen	136-137	thyroglobulin	Homo sapiens	15-17
30227620-5	2018	N-oligosaccharides play a role in Tg transport into the follicular lumen, where thyroid hormones are produced, and into thyrocytes, where hyposialylated Tg is degraded.	n-oligosaccharides	0-18	thyroglobulin	Homo sapiens	34-36
31168186-3	2018	Over the last few decades, thyroglobulin (Tg) has been established as the primary biochemical tumor marker for patients with DTC.	dtc	125-128	thyroglobulin	Homo sapiens	27-40
31168186-3	2018	Over the last few decades, thyroglobulin (Tg) has been established as the primary biochemical tumor marker for patients with DTC.	dtc	125-128	thyroglobulin	Homo sapiens	42-44
31168186-4	2018	Thyroglobulin can be measured during thyroid hormone therapy or after thyroid-stimulating hormone (TSH) stimulation, through thyroid hormone withdrawal or the use of human recombinant TSH.	Thyrotropin	70-97	thyroglobulin	Homo sapiens	0-13
31168186-4	2018	Thyroglobulin can be measured during thyroid hormone therapy or after thyroid-stimulating hormone (TSH) stimulation, through thyroid hormone withdrawal or the use of human recombinant TSH.	Thyrotropin	99-102	thyroglobulin	Homo sapiens	0-13
31168186-4	2018	Thyroglobulin can be measured during thyroid hormone therapy or after thyroid-stimulating hormone (TSH) stimulation, through thyroid hormone withdrawal or the use of human recombinant TSH.	Thyrotropin	184-187	thyroglobulin	Homo sapiens	0-13
30106632-12	2018	All 7 patients had high levels of thyroglobulin at diagnosis of metastatic DTC.	dtc	75-78	thyroglobulin	Homo sapiens	34-47
30118516-10	2018	In the subgroup analysis by risk group, TSH-stimulated serum Tg only predicted RAI-avid mLN in the low-risk group (cut-off = 1.0; HR: 5.3; p = 0.03).	Thyrotropin	40-43	thyroglobulin	Homo sapiens	61-63
30118516-11	2018	CONCLUSION: The incidence of RAI-avid mLN on postablation SPECT/CT was relatively high in both low- and intermediate-risk patients with PTC, and high preablation TSH-stimulated serum Tg level was a predictor of metastasis, especially in the low-risk group.	Thyrotropin	162-165	thyroglobulin	Homo sapiens	183-185
30118516-12	2018	A selective treatment approach should be considered in patients with high preablation TSH-stimulated serum Tg level.	Thyrotropin	86-89	thyroglobulin	Homo sapiens	107-109
29343651-12	2018	Pre-ablation serum Tg level may help patient selection and predict the response to outpatient 30 mCi RAI ablation among post total thyroidectomy non-metastatic DTC patients.	dtc	160-163	thyroglobulin	Homo sapiens	19-21
30283740-0	2018	Prognostic Value of Stimulated Thyroglobulin Levels at the Time of Radioiodine Administration in Differentiated Thyroid Cancer.	Iodine-131	67-78	thyroglobulin	Homo sapiens	31-44
29984794-1	2018	SUMMARY: Serum thyroglobulin (Tg) measurement during suppression with levothyroxine (LT4) using an ultrasensitive assay (OnT4-Tg) has been proposed as a replacement of TSH-stimulated Tg measurement (OffT4-Tg) in management of patients with differentiated thyroid cancer (DTC).	Thyroxine	70-83	thyroglobulin	Homo sapiens	15-28
29984794-1	2018	SUMMARY: Serum thyroglobulin (Tg) measurement during suppression with levothyroxine (LT4) using an ultrasensitive assay (OnT4-Tg) has been proposed as a replacement of TSH-stimulated Tg measurement (OffT4-Tg) in management of patients with differentiated thyroid cancer (DTC).	Thyroxine	85-88	thyroglobulin	Homo sapiens	15-28
28285430-0	2018	The sensitivity and specificity of thyroglobulin concentration using repeated measures of urinary iodine excretion.	Iodine	98-104	thyroglobulin	Homo sapiens	35-48
28285430-2	2018	The amount of thyroglobulin (Tg) in blood increases in iodine deficiency and also in iodine excess.	Iodine	55-61	thyroglobulin	Homo sapiens	14-27
28285430-2	2018	The amount of thyroglobulin (Tg) in blood increases in iodine deficiency and also in iodine excess.	Iodine	55-61	thyroglobulin	Homo sapiens	29-31
28285430-3	2018	Tg is considered as a sensitive index of iodine status in groups of children and adults, but its usefulness for individuals is unknown.	Iodine	41-47	thyroglobulin	Homo sapiens	0-2
28285430-4	2018	The aim of this study was to determine the diagnostic performance of Tg as an index of iodine status in individual adults.	Iodine	87-93	thyroglobulin	Homo sapiens	69-71
28285430-9	2018	Furthermore, receiver-operating characteristic (ROC) curves for Tg using the three measurements of urinary iodine were situated close to the chance line and the area under the curve ranged from 0.49 to 0.52.	Iodine	107-113	thyroglobulin	Homo sapiens	64-66
28285430-10	2018	CONCLUSIONS: The results from this cross-sectional study indicate that Tg has low sensitivity and specificity to repeated measures of urinary iodine excretion.	Iodine	142-148	thyroglobulin	Homo sapiens	71-73
28285430-11	2018	Further studies are still needed to investigate the usefulness of Tg as a biomarker of individual iodine status.	Iodine	98-104	thyroglobulin	Homo sapiens	66-68
29665748-0	2018	Low or Undetectable Basal Thyroglobulin Levels Obviate the Need for Neck Ultrasound in Differentiated Thyroid Cancer Patients After Total Thyroidectomy and 131I Ablation.	Iodine-131	156-160	thyroglobulin	Homo sapiens	26-39
29707123-10	2018	In early stage of DTC, post-therapeutic imaging (131I-pT-WBS and SPECT/CT) is an accurate method of detecting metastases, also in patients with stimulated serum Tg values &lt;=1 ng/ml.	dtc	18-21	thyroglobulin	Homo sapiens	161-163
30100941-0	2018	Response Prediction of Altered Thyroglobulin Levels After Radioactive Iodine Therapy Aided by Recombinant Human Thyrotropin in Patients with Differentiated Thyroid Cancer.	radioactive iodine	58-76	thyroglobulin	Homo sapiens	31-44
30100941-1	2018	Purpose: Thyroglobulin (Tg) may be released from damaged residual thyroid tissues after radioactive iodine (RAI) therapy in patients with differentiated thyroid carcinoma (DTC).	radioactive iodine	88-106	thyroglobulin	Homo sapiens	9-22
30100941-1	2018	Purpose: Thyroglobulin (Tg) may be released from damaged residual thyroid tissues after radioactive iodine (RAI) therapy in patients with differentiated thyroid carcinoma (DTC).	radioactive iodine	88-106	thyroglobulin	Homo sapiens	24-26
30100941-1	2018	Purpose: Thyroglobulin (Tg) may be released from damaged residual thyroid tissues after radioactive iodine (RAI) therapy in patients with differentiated thyroid carcinoma (DTC).	Insulin, Short-Acting	108-111	thyroglobulin	Homo sapiens	9-22
30100941-1	2018	Purpose: Thyroglobulin (Tg) may be released from damaged residual thyroid tissues after radioactive iodine (RAI) therapy in patients with differentiated thyroid carcinoma (DTC).	Insulin, Short-Acting	108-111	thyroglobulin	Homo sapiens	24-26
30100941-13	2018	Conclusions: Altered levels of serum Tg after RAI therapy, calculated as the ratioTg (D7Tg/D0Tg), significantly predicted an acceptable response in patients with DTC.	dtc	162-165	thyroglobulin	Homo sapiens	37-39
29860933-0	2018	Changing Trend of Thyroglobulin Antibodies in Patients With Differentiated Thyroid Cancer Treated With Total Thyroidectomy Without 131I Ablation.	Iodine-131	131-135	thyroglobulin	Homo sapiens	18-31
29860933-1	2018	BACKGROUND: Thyroglobulin (Tg) antibodies (TgAb) can interfere with Tg measurement and can be used as "Tg surrogate" in patients with differentiated thyroid cancer (DTC) treated with total thyroidectomy (TTx) and radioiodine remnant ablation (RRA).	Tetrodotoxin	204-207	thyroglobulin	Homo sapiens	12-25
29860933-1	2018	BACKGROUND: Thyroglobulin (Tg) antibodies (TgAb) can interfere with Tg measurement and can be used as "Tg surrogate" in patients with differentiated thyroid cancer (DTC) treated with total thyroidectomy (TTx) and radioiodine remnant ablation (RRA).	Iodine-131	213-224	thyroglobulin	Homo sapiens	12-25
29596381-8	2018	Increased thyroglobulin (Tg) and E-cadherin levels and appearance of membranous E-cadherin were evidenced in resveratrol-treated THJ-11T cells.	Resveratrol	109-120	thyroglobulin	Homo sapiens	10-23
29423055-1	2018	Aims: To investigate the association between angiogenetic activity of hyperplastic thymus and serum thyroglobulin (Tg) level in differentiated thyroid carcinoma patients with thyroglobulin (Tg)-elevated Negative Iodine Scintigraphy (TENIS) Syndrome.	Iodine	212-218	thyroglobulin	Homo sapiens	100-113
28593684-0	2018	Thyroglobulin level at week 16 of pregnancy is superior to urinary iodine concentration in revealing preconceptual and first trimester iodine supply.	Iodine	135-141	thyroglobulin	Homo sapiens	0-13
28593684-2	2018	Progress has recently occurred in establishing serum thyroglobulin (Tg) as an iodine status biomarker, but there is no accepted reference range for iodine sufficiency during pregnancy.	Iodine	78-84	thyroglobulin	Homo sapiens	53-66
28593684-2	2018	Progress has recently occurred in establishing serum thyroglobulin (Tg) as an iodine status biomarker, but there is no accepted reference range for iodine sufficiency during pregnancy.	Iodine	78-84	thyroglobulin	Homo sapiens	68-70
28593684-9	2018	Serum Tg concentration at week 16 of pregnancy showed negative relationship (p = .010) with duration of iodine supplementation and positive relationship (p = .008) with smoking, a known interfering factor of iodine metabolism, by multiple regression analysis.	Iodine	104-110	thyroglobulin	Homo sapiens	6-8
28593684-9	2018	Serum Tg concentration at week 16 of pregnancy showed negative relationship (p = .010) with duration of iodine supplementation and positive relationship (p = .008) with smoking, a known interfering factor of iodine metabolism, by multiple regression analysis.	Iodine	208-214	thyroglobulin	Homo sapiens	6-8
28593684-10	2018	Serum Tg at week 16 of pregnancy may be a promising biomarker of preconceptual and first trimester maternal iodine status, the critical early phase of foetal brain development.	Iodine	108-114	thyroglobulin	Homo sapiens	6-8
29423055-8	2018	Their stimulated Tg levels decreased after iodine ablation, but not drop back to normal.	Iodine	43-49	thyroglobulin	Homo sapiens	17-19
29440273-0	2018	Relationship between the dimerization of thyroglobulin and its ability to form triiodothyronine.	Triiodothyronine	79-95	thyroglobulin	Homo sapiens	41-54
29440273-2	2018	TG serves as the protein precursor in the synthesis of thyroid hormones tetraiodothyronine (T4) and triiodothyronine (T3).	Thyroxine	72-90	thyroglobulin	Homo sapiens	0-2
29440273-2	2018	TG serves as the protein precursor in the synthesis of thyroid hormones tetraiodothyronine (T4) and triiodothyronine (T3).	Triiodothyronine	100-116	thyroglobulin	Homo sapiens	0-2
29440273-2	2018	TG serves as the protein precursor in the synthesis of thyroid hormones tetraiodothyronine (T4) and triiodothyronine (T3).	Triiodothyronine	118-120	thyroglobulin	Homo sapiens	0-2
29440273-3	2018	The primary site for T3 synthesis in TG involves an iodotyrosine acceptor at the antepenultimate Tyr residue (at the extreme carboxyl terminus of the protein).	Monoiodotyrosine	52-64	thyroglobulin	Homo sapiens	37-39
29440273-3	2018	The primary site for T3 synthesis in TG involves an iodotyrosine acceptor at the antepenultimate Tyr residue (at the extreme carboxyl terminus of the protein).	Tyrosine	97-100	thyroglobulin	Homo sapiens	37-39
29440273-8	2018	T3 formation in TG, or the isolated carboxyl-terminal region, is inhibited by mutation of this antepenultimate residue, but we describe the first substitution mutation that actually increases T3 hormonogenesis by engineering a novel cysteine, 10 residues upstream of the antepenultimate residue, allowing for covalent association of the unique tail sequences, and that helps to bring residues Tyr2744 from apposed monomers into closer proximity.	Cysteine	233-241	thyroglobulin	Homo sapiens	16-18
29130586-1	2018	BACKGROUND: Fluorine-18 fluorodeoxyglucose positron emission tomography/CT (18 F-FDG PET/CT) has been widely accepted as an effective method for detecting recurrent papillary thyroid cancer (PTC) in patients with increased serum thyroglobulin (Tg) or Tg antibody (TgAb) levels and negative whole-body scintigraphy (WBS) results.	Fluorodeoxyglucose F18	12-42	thyroglobulin	Homo sapiens	229-242
29731797-0	2018	The Association between ocular problems and Serum Testosterone, Prolactin and Thyroglobulin concentrations in Delayed phase of Sulfur Mustard exposure.	Mustard Gas	127-141	thyroglobulin	Homo sapiens	78-91
29731797-11	2018	In the chronic phase of SM toxicity, some ocular surface problems are associated with alterations in the serum concentrations of testosterone, prolactin, and Tg.	Mustard Gas	24-26	thyroglobulin	Homo sapiens	158-160
29423055-1	2018	Aims: To investigate the association between angiogenetic activity of hyperplastic thymus and serum thyroglobulin (Tg) level in differentiated thyroid carcinoma patients with thyroglobulin (Tg)-elevated Negative Iodine Scintigraphy (TENIS) Syndrome.	Iodine	212-218	thyroglobulin	Homo sapiens	115-117
29423055-1	2018	Aims: To investigate the association between angiogenetic activity of hyperplastic thymus and serum thyroglobulin (Tg) level in differentiated thyroid carcinoma patients with thyroglobulin (Tg)-elevated Negative Iodine Scintigraphy (TENIS) Syndrome.	Iodine	212-218	thyroglobulin	Homo sapiens	175-188
29423055-1	2018	Aims: To investigate the association between angiogenetic activity of hyperplastic thymus and serum thyroglobulin (Tg) level in differentiated thyroid carcinoma patients with thyroglobulin (Tg)-elevated Negative Iodine Scintigraphy (TENIS) Syndrome.	Iodine	212-218	thyroglobulin	Homo sapiens	190-192
28620714-3	2017	Successful ablation was defined as the absence of visible iodine-131 (I-131) accumulation in the thyroid bed after whole-body scans and thyroglobulin levels &lt;2 ng/ml in a TSH-stimulated state after ablation.	Thyrotropin	174-177	thyroglobulin	Homo sapiens	136-149
28153798-4	2017	The iodination of the tyrosyl residues of TG preceeds TH biosynthesis, which depends on the interaction of iodide, TG, hydrogen peroxide (H2O2) and thyroid peroxidase (TPO) at the apical plasma membrane of thyrocytes.	cyclo(tyrosyl-tyrosyl)	22-29	thyroglobulin	Homo sapiens	42-44
28153798-4	2017	The iodination of the tyrosyl residues of TG preceeds TH biosynthesis, which depends on the interaction of iodide, TG, hydrogen peroxide (H2O2) and thyroid peroxidase (TPO) at the apical plasma membrane of thyrocytes.	cyclo(tyrosyl-tyrosyl)	22-29	thyroglobulin	Homo sapiens	115-117
28153798-4	2017	The iodination of the tyrosyl residues of TG preceeds TH biosynthesis, which depends on the interaction of iodide, TG, hydrogen peroxide (H2O2) and thyroid peroxidase (TPO) at the apical plasma membrane of thyrocytes.	Iodides	107-113	thyroglobulin	Homo sapiens	42-44
28153798-4	2017	The iodination of the tyrosyl residues of TG preceeds TH biosynthesis, which depends on the interaction of iodide, TG, hydrogen peroxide (H2O2) and thyroid peroxidase (TPO) at the apical plasma membrane of thyrocytes.	Hydrogen Peroxide	119-136	thyroglobulin	Homo sapiens	42-44
28153798-4	2017	The iodination of the tyrosyl residues of TG preceeds TH biosynthesis, which depends on the interaction of iodide, TG, hydrogen peroxide (H2O2) and thyroid peroxidase (TPO) at the apical plasma membrane of thyrocytes.	Hydrogen Peroxide	138-142	thyroglobulin	Homo sapiens	42-44
29412384-1	2017	OBJECTIVES: We sought to assess the relationship between stimulated thyroglobulin (sTg) before radioactive iodine therapy (RIT), and the dynamic risk stratification 1 year after treatment, and to establish the utility of the sTg as a predictor of response to therapy in these patients.	Ritonavir	123-126	thyroglobulin	Homo sapiens	68-81
29412384-1	2017	OBJECTIVES: We sought to assess the relationship between stimulated thyroglobulin (sTg) before radioactive iodine therapy (RIT), and the dynamic risk stratification 1 year after treatment, and to establish the utility of the sTg as a predictor of response to therapy in these patients.	estriol 3-glucuronide	83-86	thyroglobulin	Homo sapiens	68-81
28688088-0	2017	Early stimulated thyroglobulin for response prediction after recombinant human thyrotropin-aided radioiodine therapy.	Iodine-131	97-108	thyroglobulin	Homo sapiens	17-30
28688088-2	2017	However, due to the acute effect of I-131 on thyrocytes, Tg measured after radioiodine therapy (RIT) would not accurately reflect the thyroid tissue burden.	Iodine-131	75-86	thyroglobulin	Homo sapiens	57-59
28688088-2	2017	However, due to the acute effect of I-131 on thyrocytes, Tg measured after radioiodine therapy (RIT) would not accurately reflect the thyroid tissue burden.	Ritonavir	96-99	thyroglobulin	Homo sapiens	57-59
28688088-11	2017	CONCLUSIONS: Early stimulated Tg significantly predicted therapeutic response after rhTSH-aided RIT in patients with DTC.	dtc	117-120	thyroglobulin	Homo sapiens	30-32
29049252-1	2017	BACKGROUND: To assess the long-term prognostic value of F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with differentiated thyroid carcinoma (DTC) undergoing empiric radioiodine (RAI) therapy due to raising values of thyroglobulin (Tg).	fluorescein-digalactoside	78-81	thyroglobulin	Homo sapiens	267-280
28743746-6	2017	We present data suggesting that TSH-stimulated TG phosphorylation contributes to enhanced de novo T3 formation.	Thyrotropin	32-35	thyroglobulin	Homo sapiens	47-49
27629910-10	2017	Blood collected in K2-EDTA tubes, but not in PAXgene and Tempus tubes, showed significant changes in thyroglobulin mRNA levels following storage for 72 h at room temperature ( P = 0.0263).	k2-edta	19-26	thyroglobulin	Homo sapiens	101-114
28543974-0	2017	Neck Sonography and Suppressed Thyroglobulin Have High Sensitivity for Identifying Recurrent/Persistent Disease in Patients With Low-risk Thyroid Cancer Treated With Total Thyroidectomy and Radioactive Iodine Ablation, Making Stimulated Thyroglobulin Unnecessary.	radioactive iodine	190-208	thyroglobulin	Homo sapiens	31-44
28543974-1	2017	OBJECTIVES: Follow-up of patients with low-risk differentiated thyroid cancer treated with total thyroidectomy and radioiodine requires neck sonography and thyroglobulin (Tg).	Iodine-131	115-126	thyroglobulin	Homo sapiens	156-169
29264468-8	2017	The patient developed hypothyroidism 2 months after RAI administration; 6 months after RAI administration, her thyroglobulin (Tg) levels had fallen from a peak of 1976 ng/mL to 1.4 ng/mL.	Insulin, Short-Acting	87-90	thyroglobulin	Homo sapiens	111-124
28599610-0	2017	Re: "Thyroglobulin as a Functional Biomarker of Iodine Status in a Cohort Study of Pregnant Women in the United Kingdom" by Bath et al.	Iodine	48-54	thyroglobulin	Homo sapiens	5-18
28585147-1	2017	This study was to explore the optimal threshold of thyroid-stimulating hormone (TSH)-stimulated serum thyroglobulin (s-Tg) for patients who were to receive 18F-fluorodeoxyglucose (18F-FDG) PET/CT scan owing to clinical suspicion of differentiated thyroid cancer (DTC) recurrence but negative post-therapeutic 131I whole-body scan (131I-WBS).	Fluorodeoxyglucose F18	156-178	thyroglobulin	Homo sapiens	102-115
28704384-0	2017	Quantitative thyroglobulin response to radioactive iodine treatment in predicting radioactive iodine-refractory thyroid cancer with pulmonary metastasis.	radioactive iodine	39-57	thyroglobulin	Homo sapiens	13-26
28704384-0	2017	Quantitative thyroglobulin response to radioactive iodine treatment in predicting radioactive iodine-refractory thyroid cancer with pulmonary metastasis.	Iodine	51-57	thyroglobulin	Homo sapiens	13-26
28756810-0	2017	Serum Thyroglobulin-A Sensitive Biomarker of Iodine Nutrition Status and Affected by Thyroid Abnormalities and Disease in Adult Populations.	Iodine	45-51	thyroglobulin	Homo sapiens	6-19
28756810-1	2017	OBJECTIVE: To evaluate the usefulness of the thyroglobulin (Tg) level in adults as a nutritional biomarker of iodine status and to identify the factors related to the serum Tg level.	Iodine	110-116	thyroglobulin	Homo sapiens	45-58
28756810-1	2017	OBJECTIVE: To evaluate the usefulness of the thyroglobulin (Tg) level in adults as a nutritional biomarker of iodine status and to identify the factors related to the serum Tg level.	Iodine	110-116	thyroglobulin	Homo sapiens	60-62
28756810-5	2017	A multivariate linear regression analysis was used to assess iodine intake and other indeterminate factors associated with the serum Tg level.	Iodine	61-67	thyroglobulin	Homo sapiens	133-135
28756810-8	2017	The results of multivariate linear regression analysis indicate that excess and deficient iodine intake, goiter, thyroid nodule, hypothyroidism are significantly related with higher Tg level, and TgAb positivity is significantly related with lower serum Tg.	Iodine	90-96	thyroglobulin	Homo sapiens	182-184
28756810-9	2017	CONCLUSION: The serum Tg level reflects abnormal thyroid function and is a sensitive functional biomarker of iodine nutrition status.	Iodine	109-115	thyroglobulin	Homo sapiens	22-24
28505591-1	2017	BACKGROUND: Serum thyroglobulin (Tg) is associated with the presence of thyroid disease and has been proposed as a biomarker of iodine status.	Iodine	128-134	thyroglobulin	Homo sapiens	18-31
28505591-1	2017	BACKGROUND: Serum thyroglobulin (Tg) is associated with the presence of thyroid disease and has been proposed as a biomarker of iodine status.	Iodine	128-134	thyroglobulin	Homo sapiens	33-35
28505591-2	2017	Few studies have examined factors related to serum Tg in populations environmentally exposed to ionizing radiation and living in regions with endemic mild-to-moderate iodine deficiency.	Iodine	167-173	thyroglobulin	Homo sapiens	51-53
28505591-4	2017	We estimated the percent change (PC) in serum Tg associated with demographic factors, iodine-131 thyroid dose, and indicators of thyroid structure and function using linear regression.	Iodine	86-92	thyroglobulin	Homo sapiens	46-48
28505591-9	2017	Serum Tg levels were inversely associated with iodized salt intake (PC=-7.90, 95% confidence interval: -12.08, -3.52), and over the range of urinary iodine concentration, the odds of having elevated serum Tg showed a U-shaped curve with elevated Tg at low and high urinary iodine concentrations.	Salts	55-59	thyroglobulin	Homo sapiens	6-8
28505591-9	2017	Serum Tg levels were inversely associated with iodized salt intake (PC=-7.90, 95% confidence interval: -12.08, -3.52), and over the range of urinary iodine concentration, the odds of having elevated serum Tg showed a U-shaped curve with elevated Tg at low and high urinary iodine concentrations.	Iodine	149-155	thyroglobulin	Homo sapiens	6-8
28505591-9	2017	Serum Tg levels were inversely associated with iodized salt intake (PC=-7.90, 95% confidence interval: -12.08, -3.52), and over the range of urinary iodine concentration, the odds of having elevated serum Tg showed a U-shaped curve with elevated Tg at low and high urinary iodine concentrations.	Iodine	273-279	thyroglobulin	Homo sapiens	6-8
28505591-10	2017	CONCLUSION: Serum Tg may be a useful indicator of population iodine status and a non-specific biomarker of structural and functional thyroid abnormalities in epidemiological studies.	Iodine	61-67	thyroglobulin	Homo sapiens	18-20
28258491-0	2017	Stimulated thyroglobulin values above 5.6 ng/ml before radioactive iodine ablation treatment following levothyroxine withdrawal is associated with a 2.38-fold risk of relapse in Tg-ab negative subjects with differentiated thyroid cancer.	Thyroxine	103-116	thyroglobulin	Homo sapiens	11-24
28209262-0	2017	Biotin interferes with free thyroid hormone and thyroglobulin, but not TSH measurements using Beckman-Access immunoassays.	Biotin	0-6	thyroglobulin	Homo sapiens	48-61
28505591-0	2017	Factors associated with serum thyroglobulin in a Ukrainian cohort exposed to iodine-131 from the accident at the Chernobyl Nuclear Plant.	Iodine-131	77-87	thyroglobulin	Homo sapiens	30-43
28620499-0	2017	Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation.	Triiodothyronine	43-59	thyroglobulin	Homo sapiens	163-176
28620499-0	2017	Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation.	Thyroxine	64-73	thyroglobulin	Homo sapiens	163-176
28346249-0	2017	Usefulness of 68Ga-DOTA-RGD (alphavbeta3) PET/CT Imaging in Thyroglobulin Elevation With Negative Iodine Scintigraphy.	Iodine	98-104	thyroglobulin	Homo sapiens	60-73
28346249-1	2017	TENIS (thyroglobulin elevation with negative iodine scintigraphy) syndrome in patients with differentiated thyroid carcinoma is not a rare finding.	Iodine	45-51	thyroglobulin	Homo sapiens	7-20
28586450-0	2017	Letter to the Editor: What Is the Role of Serum Thyroglobulin Measurement in Patients With Differentiated Thyroid Cancer Treated Without Radioactive Iodine?	radioactive iodine	137-155	thyroglobulin	Homo sapiens	48-61
28585147-1	2017	This study was to explore the optimal threshold of thyroid-stimulating hormone (TSH)-stimulated serum thyroglobulin (s-Tg) for patients who were to receive 18F-fluorodeoxyglucose (18F-FDG) PET/CT scan owing to clinical suspicion of differentiated thyroid cancer (DTC) recurrence but negative post-therapeutic 131I whole-body scan (131I-WBS).	Fluorodeoxyglucose F18	183-187	thyroglobulin	Homo sapiens	102-115
28482079-0	2017	Letter to the Editor: "Postoperative Thyroglobulin and Neck Ultrasound in the Risk Restratification and Decision to Perform 131I Ablation".	Iodine-131	124-128	thyroglobulin	Homo sapiens	37-50
27909769-1	2017	AIM: To study the clinical yield of diagnostic whole body 131I scintigraphy (DxWBS) in the follow-up of differentiated thyroid carcinoma (DTC) patients in relation to stimulated thyroglobulin (sTg) in the initial post-ablation setting, as well as in the setting of repeated monitoring in course of further DTC follow-up.	Iodine-131	58-62	thyroglobulin	Homo sapiens	178-191
27909769-1	2017	AIM: To study the clinical yield of diagnostic whole body 131I scintigraphy (DxWBS) in the follow-up of differentiated thyroid carcinoma (DTC) patients in relation to stimulated thyroglobulin (sTg) in the initial post-ablation setting, as well as in the setting of repeated monitoring in course of further DTC follow-up.	dxwbs	77-82	thyroglobulin	Homo sapiens	178-191
28291505-6	2017	The serum TSH and Tg levels became lower, without replacement therapy, after the initiation of hemodialysis and iodine restriction, and there was a significant correlation between the serum TSH and Tg levels in the CKD 5 patients (p &lt; 0.05).	Iodine	112-118	thyroglobulin	Homo sapiens	18-20
28291505-7	2017	CONCLUSION: The high prevalence of reversible hypothyroidism and the TSH-dependent elevation of the serum Tg levels was suggested in Japanese patients with advanced CKD.	Thyrotropin	69-72	thyroglobulin	Homo sapiens	106-108
28482084-0	2017	Response to Letter: "Postoperative Thyroglobulin and Neck Ultrasound in the Risk Restratification and Decision to Perform 131I Ablation".	Iodine-131	122-126	thyroglobulin	Homo sapiens	35-48
27929713-0	2017	Postoperative Thyroglobulin and Neck Ultrasound in the Risk Restratification and Decision to Perform 131I Ablation.	Iodine-131	101-105	thyroglobulin	Homo sapiens	14-27
28290237-5	2017	SUMMARY: Chronic exposure to excess iodine intake induces autoimmune thyroiditis, partly because highly iodinated thyroglobulin (Tg) is more immunogenic.	Iodine	36-42	thyroglobulin	Homo sapiens	114-127
28377330-4	2017	In albumin free saline solution, thyroglobulin recovery rates depended on initial sample concentrations and on modalities of their conservation (in conventional storage tubes, recovery mean was 56% after 3 hours-storage at room temperature and 19% after 24 hours-storage for concentrations ranged from 2 to 183 mug/L; recovery was 95%, after 3 hours or 24 hours-storage at room temperature, for a concentration of 5,656 mug/L).	Sodium Chloride	16-22	thyroglobulin	Homo sapiens	33-46
28377330-7	2017	In conclusion, non-specific adsorption in storage tubes strongly contributes to uncertainty in thyroglobulin measurement in physiological saline solution.	Sodium Chloride	138-144	thyroglobulin	Homo sapiens	95-108
28079354-5	2017	The major proportion of iodine in the thyroid gland is bound to Thyroglobulin.	Iodine	24-30	thyroglobulin	Homo sapiens	64-77
29264493-4	2017	Laboratory studies showed an elevated thyroglobulin level of 35 ng/mL while on suppressive levothyroxine therapy.	Thyroxine	91-104	thyroglobulin	Homo sapiens	38-51
29264493-5	2017	During preparation for radioactive iodine ablation, thyroglobulin increased dramatically to 3490 ng/mL.	radioactive iodine	23-41	thyroglobulin	Homo sapiens	52-65
27929713-2	2017	Objective: The aim of this study was to evaluate the role of postoperative high-sensitive thyroglobulin (Tg) on L-thyroxine (LT4-HSTg) and postoperative neck ultrasound (US) in risk restratification and decision to perform RRA.	Thyroxine	112-123	thyroglobulin	Homo sapiens	90-103
27762729-0	2017	Thyroglobulin as a Functional Biomarker of Iodine Status in a Cohort Study of Pregnant Women in the United Kingdom.	Iodine	43-49	thyroglobulin	Homo sapiens	0-13
27732337-0	2017	Dried Blood Spot Thyroglobulin as a Biomarker of Iodine Status in Pregnant Women.	Iodine	49-55	thyroglobulin	Homo sapiens	17-30
27144920-0	2017	Thyroglobulin levels and thyroglobulin/thyrotropin ratio could predict the success of the ablative/therapeutic 131I in the differentiated thyroid cancers.	Iodine-131	111-115	thyroglobulin	Homo sapiens	0-13
27838902-5	2017	TGN levels for those males who were in third tertile of TCPY were statistically significantly lower (p &lt; 0.01) than for those who had their TCPY levels in first or second tertile.	3,5,6-trichloro-2-pyridinol	56-60	thyroglobulin	Homo sapiens	0-3
27838902-5	2017	TGN levels for those males who were in third tertile of TCPY were statistically significantly lower (p &lt; 0.01) than for those who had their TCPY levels in first or second tertile.	3,5,6-trichloro-2-pyridinol	143-147	thyroglobulin	Homo sapiens	0-3
28222819-0	2017	Reliability of thyroglobulin in serum compared with urinary iodine when assessing individual and population iodine nutrition status.	Iodine	108-114	thyroglobulin	Homo sapiens	15-28
27519283-0	2017	Gestation-specific changes in maternal thyroglobulin during pregnancy and lactation in an iodine-sufficient region in China: a longitudinal study.	Iodine	90-96	thyroglobulin	Homo sapiens	39-52
27144920-0	2017	Thyroglobulin levels and thyroglobulin/thyrotropin ratio could predict the success of the ablative/therapeutic 131I in the differentiated thyroid cancers.	Iodine-131	111-115	thyroglobulin	Homo sapiens	25-38
27144920-1	2017	BACKGROUND: Stimulated thyroglobulin (STg) levels in patients with differentiated thyroid carcinomas (DTCs) after total thyroidectomy (TT) and before radioactive iodine (131I) ablation/therapy (RIT) are predictive of therapeutic success but can be influenced by the thyroid-stimulating hormone (TSH) level.	Ritonavir	194-197	thyroglobulin	Homo sapiens	23-36
27144920-1	2017	BACKGROUND: Stimulated thyroglobulin (STg) levels in patients with differentiated thyroid carcinomas (DTCs) after total thyroidectomy (TT) and before radioactive iodine (131I) ablation/therapy (RIT) are predictive of therapeutic success but can be influenced by the thyroid-stimulating hormone (TSH) level.	Thyrotropin	266-293	thyroglobulin	Homo sapiens	23-36
27144920-1	2017	BACKGROUND: Stimulated thyroglobulin (STg) levels in patients with differentiated thyroid carcinomas (DTCs) after total thyroidectomy (TT) and before radioactive iodine (131I) ablation/therapy (RIT) are predictive of therapeutic success but can be influenced by the thyroid-stimulating hormone (TSH) level.	Thyrotropin	295-298	thyroglobulin	Homo sapiens	23-36
28090499-0	2017	Risk factors associated with high thyroglobulin level following radioactive iodine ablation, measured 12 months after treatment for papillary thyroid carcinoma.	radioactive iodine	64-82	thyroglobulin	Homo sapiens	34-47
27732337-1	2017	Context: Thyroglobulin (Tg) could be a sensitive biomarker of iodine nutrition in pregnant women (PW).	Iodine	62-68	thyroglobulin	Homo sapiens	9-22
28076008-8	2017	SPECT/CT has been documented to be of incremental value in the accurate anatomic localization and characterization of radioiodine uptake as false-positive findings, particularly in cases with discordant findings of a low serum thyroglobulin level but positive findings on radioiodine whole-body planar scintigrams.	Iodine-131	118-129	thyroglobulin	Homo sapiens	227-240
27902589-0	2016	Serum thyroglobulin reference intervals in regions with adequate and more than adequate iodine intake.	Iodine	88-94	thyroglobulin	Homo sapiens	6-19
27994688-0	2016	Iodine Uptake Patterns on Post-ablation Whole Body Scans are Related to Elevated Serum Thyroglobulin Levels After Radioactive Iodine Therapy in Patients with Papillary Thyroid Carcinoma.	Iodine	0-6	thyroglobulin	Homo sapiens	87-100
27994688-0	2016	Iodine Uptake Patterns on Post-ablation Whole Body Scans are Related to Elevated Serum Thyroglobulin Levels After Radioactive Iodine Therapy in Patients with Papillary Thyroid Carcinoma.	radioactive iodine	114-132	thyroglobulin	Homo sapiens	87-100
27994688-1	2016	PURPOSE: Serum thyroglobulin (Tg) level is frequently elevated shortly after radioactive iodine (RAI) ablation therapy.	radioactive iodine	77-95	thyroglobulin	Homo sapiens	15-28
27994688-1	2016	PURPOSE: Serum thyroglobulin (Tg) level is frequently elevated shortly after radioactive iodine (RAI) ablation therapy.	Insulin, Short-Acting	97-100	thyroglobulin	Homo sapiens	15-28
26668060-1	2016	Papillary thyroid cancer (PTC) patients treated with thyroidectomy and radioiodine remnant ablation (RRA) often have detectable TSH-stimulated thyroglobulin (Tg) levels without localizable disease after primary treatment.	Iodine-131	71-82	thyroglobulin	Homo sapiens	143-156
26668060-1	2016	Papillary thyroid cancer (PTC) patients treated with thyroidectomy and radioiodine remnant ablation (RRA) often have detectable TSH-stimulated thyroglobulin (Tg) levels without localizable disease after primary treatment.	Iodine-131	71-82	thyroglobulin	Homo sapiens	158-160
27902589-6	2016	Stepwise linear regression analyses showed that TgAb, thyroid volume, goiter, gender, age, and TSH levels were correlated with Tg.In adults from regions with adequate and more than adequate iodine intake, we found that Tg may be a suitable marker of iodine status; gender-specific Tg RI was unnecessary; there was no difference between Tg RIs in regions with adequate and more than adequate iodine intake; and the TSH criterion for selecting the Tg reference population could follow the local TSH reference rather than 0.5 to 2.0 mIU/L.	Thyrotropin	95-98	thyroglobulin	Homo sapiens	127-129
27902589-6	2016	Stepwise linear regression analyses showed that TgAb, thyroid volume, goiter, gender, age, and TSH levels were correlated with Tg.In adults from regions with adequate and more than adequate iodine intake, we found that Tg may be a suitable marker of iodine status; gender-specific Tg RI was unnecessary; there was no difference between Tg RIs in regions with adequate and more than adequate iodine intake; and the TSH criterion for selecting the Tg reference population could follow the local TSH reference rather than 0.5 to 2.0 mIU/L.	Thyrotropin	95-98	thyroglobulin	Homo sapiens	127-129
27902589-6	2016	Stepwise linear regression analyses showed that TgAb, thyroid volume, goiter, gender, age, and TSH levels were correlated with Tg.In adults from regions with adequate and more than adequate iodine intake, we found that Tg may be a suitable marker of iodine status; gender-specific Tg RI was unnecessary; there was no difference between Tg RIs in regions with adequate and more than adequate iodine intake; and the TSH criterion for selecting the Tg reference population could follow the local TSH reference rather than 0.5 to 2.0 mIU/L.	Thyrotropin	95-98	thyroglobulin	Homo sapiens	127-129
27902589-6	2016	Stepwise linear regression analyses showed that TgAb, thyroid volume, goiter, gender, age, and TSH levels were correlated with Tg.In adults from regions with adequate and more than adequate iodine intake, we found that Tg may be a suitable marker of iodine status; gender-specific Tg RI was unnecessary; there was no difference between Tg RIs in regions with adequate and more than adequate iodine intake; and the TSH criterion for selecting the Tg reference population could follow the local TSH reference rather than 0.5 to 2.0 mIU/L.	Thyrotropin	95-98	thyroglobulin	Homo sapiens	127-129
27751976-3	2016	Within 12 months of thyroidectomy and radioiodine ablation, thyroglobulin (Tg) levels were elevated.	Iodine-131	38-49	thyroglobulin	Homo sapiens	60-73
27751976-3	2016	Within 12 months of thyroidectomy and radioiodine ablation, thyroglobulin (Tg) levels were elevated.	Iodine-131	38-49	thyroglobulin	Homo sapiens	75-77
27751976-4	2016	Second radioiodine ablative dose was given, however, stimulated Tg levels showed an upward trend with negative iodine scan within 12 months.	Iodine-131	7-18	thyroglobulin	Homo sapiens	64-66
27751976-4	2016	Second radioiodine ablative dose was given, however, stimulated Tg levels showed an upward trend with negative iodine scan within 12 months.	Iodine	12-18	thyroglobulin	Homo sapiens	64-66
27033897-11	2016	CONCLUSION: 68Ga-DOTATOC PET/CT should be considered in the case of negative 18F-FDG PET/CT in radioiodine-negative DTC patients with elevated and rising thyroglobulin.	dtc	116-119	thyroglobulin	Homo sapiens	154-167
26801644-0	2016	Low postoperative nonstimulated thyroglobulin as a criterion for the indication of low radioiodine activity in patients with papillary thyroid cancer of intermediate risk "with higher risk features".	Iodine-131	87-98	thyroglobulin	Homo sapiens	32-45
27213699-0	2016	Commentary on the use of thyroglobulin as a biomarker for iodine status in adults.	Iodine	58-64	thyroglobulin	Homo sapiens	25-38
26833982-0	2016	Recombinant human thyrotropin-stimulated thyroglobulin level at the time of radioactive iodine ablation is an independent prognostic marker of differentiated thyroid carcinoma in the setting of prophylactic central neck dissection.	radioactive iodine	76-94	thyroglobulin	Homo sapiens	41-54
27824959-2	2016	In 10%-30% of patients with DTC after ablation therapy during the follow-up show a negative iodine-131 (131I) whole-body screening test (131I WBS) and increased serum thyroglobulin (Tg) level.	dtc	28-31	thyroglobulin	Homo sapiens	167-180
27824959-2	2016	In 10%-30% of patients with DTC after ablation therapy during the follow-up show a negative iodine-131 (131I) whole-body screening test (131I WBS) and increased serum thyroglobulin (Tg) level.	dtc	28-31	thyroglobulin	Homo sapiens	182-184
26851767-0	2016	Serum thyroglobulin as a biomarker of iodine deficiency in adult populations.	Iodine	38-44	thyroglobulin	Homo sapiens	6-19
26599499-10	2016	We propose that the major thyroglobulin endocytosis described in thyroid autonomous adenomas due to Rab7 increased expression, occurs via CDRs.	cdrs	138-142	thyroglobulin	Homo sapiens	26-39
27383190-1	2016	INTRODUCTION: PET/computed tomography (CT) using fluorine-18 fluorodeoxyglucose (F-FDG) has been used in the diagnosis of recurrence and metastases of differentiated thyroid cancer (DTC) in cases of negative whole-body scan (WBS) despite elevated concentrations of stimulated thyroglobulin (Tg).	Fluorodeoxyglucose F18	49-79	thyroglobulin	Homo sapiens	276-289
27383190-1	2016	INTRODUCTION: PET/computed tomography (CT) using fluorine-18 fluorodeoxyglucose (F-FDG) has been used in the diagnosis of recurrence and metastases of differentiated thyroid cancer (DTC) in cases of negative whole-body scan (WBS) despite elevated concentrations of stimulated thyroglobulin (Tg).	dtc	182-185	thyroglobulin	Homo sapiens	276-289
27493886-0	2016	Serum Thyroglobulin Concentration Is a Weak Marker of Iodine Status in a Pregnant Population with Iodine Deficiency.	Iodine	54-60	thyroglobulin	Homo sapiens	6-19
28530326-0	2016	[SERUM THYROGLOBULIN LEVELS AND ESTIMATED IODINE INTAKE IN ADULTS EXPOSED TO IODINE-DILUTED DESALINATED DRINKING WATER].	Iodine	77-83	thyroglobulin	Homo sapiens	7-20
28530326-0	2016	[SERUM THYROGLOBULIN LEVELS AND ESTIMATED IODINE INTAKE IN ADULTS EXPOSED TO IODINE-DILUTED DESALINATED DRINKING WATER].	Water	113-118	thyroglobulin	Homo sapiens	7-20
27455319-11	2016	Synthetic thyroxine use was associated with lower odds of having a UIC &lt; 50 mug/L (OR 0.32, p = 0.030)) and lower median thyroglobulin (-15.2 ng/mL, p = 0.001), compared with untreated participants.	Thyroxine	10-19	thyroglobulin	Homo sapiens	124-137
27493886-0	2016	Serum Thyroglobulin Concentration Is a Weak Marker of Iodine Status in a Pregnant Population with Iodine Deficiency.	Iodine	98-104	thyroglobulin	Homo sapiens	6-19
27493886-1	2016	OBJECTIVE: To assess the reliability of thyroglobulin (Tg) as a marker of iodine status during pregnancy.	Iodine	74-80	thyroglobulin	Homo sapiens	40-53
27493886-1	2016	OBJECTIVE: To assess the reliability of thyroglobulin (Tg) as a marker of iodine status during pregnancy.	Iodine	74-80	thyroglobulin	Homo sapiens	55-57
27493886-13	2016	Further studies in a larger patient cohort with differences in iodine status, as well as studies on Tg changes after improving iodine status in pregnant women, are needed in order to corroborate these results.	Iodine	127-133	thyroglobulin	Homo sapiens	100-102
27376428-8	2016	TSH:Tg levels were found to be significantly higher in patients with malignant thyroid diseases (0.24+-1 vs. 0.87+-3.4, p=0.024).	Thyrotropin	0-3	thyroglobulin	Homo sapiens	4-6
27376428-11	2016	However, a higher preoperative serum TSH:Tg ratio may hint at an increased risk for thyroid carcinoma.	Thyrotropin	37-40	thyroglobulin	Homo sapiens	41-43
27488338-0	2016	Elevated serum thyroglobulin levels at the time of ablative radioactive iodine therapy indicate a worse prognosis in thyroid cancer: an Australian retrospective cohort study.	radioactive iodine	60-78	thyroglobulin	Homo sapiens	15-28
27488338-2	2016	This study investigates whether thyroglobulin measured at the time of ablative radioactive iodine therapy predicts disease-free survival.	radioactive iodine	79-97	thyroglobulin	Homo sapiens	32-45
27488338-4	2016	Disease-free survival of patients with a significantly elevated stimulated thyroglobulin level (27.5 microg/l or higher) at the time of ablative radioactive iodine therapy was compared to that of patients without a significantly elevated thyroglobulin level using univariate analysis.	Iodine	157-163	thyroglobulin	Homo sapiens	75-88
27488338-7	2016	CONCLUSION: An elevated thyroglobulin level of 27.5 microg/l or higher at the time of ablative radioactive iodine therapy is a prognostic indicator for macroscopic disease recurrence in well-differentiated thyroid carcinoma.	radioactive iodine	95-113	thyroglobulin	Homo sapiens	24-37
27306607-0	2016	Thyroglobulin fluctuations in patients with iodine-refractory differentiated thyroid carcinoma on lenvatinib treatment - initial experience.	Iodine	44-50	thyroglobulin	Homo sapiens	0-13
27306607-0	2016	Thyroglobulin fluctuations in patients with iodine-refractory differentiated thyroid carcinoma on lenvatinib treatment - initial experience.	lenvatinib	98-108	thyroglobulin	Homo sapiens	0-13
27306607-2	2016	The corresponding role of serum thyroglobulin (Tg) in iodine-refractory DTC has not been investigated yet.	Iodine	54-60	thyroglobulin	Homo sapiens	32-45
27306607-2	2016	The corresponding role of serum thyroglobulin (Tg) in iodine-refractory DTC has not been investigated yet.	Iodine	54-60	thyroglobulin	Homo sapiens	47-49
27306607-2	2016	The corresponding role of serum thyroglobulin (Tg) in iodine-refractory DTC has not been investigated yet.	dtc	72-75	thyroglobulin	Homo sapiens	32-45
27306607-2	2016	The corresponding role of serum thyroglobulin (Tg) in iodine-refractory DTC has not been investigated yet.	dtc	72-75	thyroglobulin	Homo sapiens	47-49
27306607-10	2016	Initiation of lenvatinib in iodine-refractory DTC patients is associated with a significant reduction in serum Tg levels as a marker of treatment response.	lenvatinib	14-24	thyroglobulin	Homo sapiens	111-113
27306607-10	2016	Initiation of lenvatinib in iodine-refractory DTC patients is associated with a significant reduction in serum Tg levels as a marker of treatment response.	Iodine	28-34	thyroglobulin	Homo sapiens	111-113
27020734-1	2016	BACKGROUND: The management of patients with differentiated thyroid carcinoma (DTC) showing low levels of serum thyroglobulin autoantibodies (TgAb) and undetectable Tg after thyroidectomy is unsettled.	Thioguanine	141-143	thyroglobulin	Homo sapiens	111-124
27376428-9	2016	Although univariate analysis showed that the TSH:Tg ratio was a predictor for thyroid malignancy (OR 0.001; 95% CI, 0.01-0.125; p=0.007) in conjunction with FNAB, multivariate analysis failed to demonstrate any statistical significance for any factor except FNAB.	Thyrotropin	45-48	thyroglobulin	Homo sapiens	49-51
28856198-1	2016	OBJECTIVES: Thyroglobulin (Tg) measurements are used to monitor for residual thyroid tissue in patients with differentiated thyroid cancer (DTC) after thyroidectomy and radioiodine ablative therapy.	Iodine-131	169-180	thyroglobulin	Homo sapiens	12-25
26985823-6	2016	DEHP and its monoester, MEHP, both had an inhibitory influence on 3"-5"-cyclic adenosine monophosphate secretion from the cells, and MEHP also on thyroglobulin (Tg) secretion from the cells.	mono-(2-ethylhexyl)phthalate	24-28	thyroglobulin	Homo sapiens	146-159
26985823-6	2016	DEHP and its monoester, MEHP, both had an inhibitory influence on 3"-5"-cyclic adenosine monophosphate secretion from the cells, and MEHP also on thyroglobulin (Tg) secretion from the cells.	mono-(2-ethylhexyl)phthalate	24-28	thyroglobulin	Homo sapiens	161-163
27461690-0	2016	What is the role of florine-18 fluorodeoxyglucose/positron emission tomography/computed tomography imaging in well-differentiated thyroid cancers with negative iodine-131 scan high thyroglobulin and normal anti-thyroglobulin levels.	florine-18 fluorodeoxyglucose	20-49	thyroglobulin	Homo sapiens	181-194
26909485-1	2016	Thyroglobulin (Tg) is the major glycoprotein produced by the thyroid gland, where it serves as a template for thyroid hormone synthesis and as an intraglandular store of iodine.	Iodine	170-176	thyroglobulin	Homo sapiens	0-13
26929643-7	2016	In addition, the Tg levels in the (99m)Tc-MIBI(+)/(131)I(-) group were significantly higher than that in the (131)I(+)/(99m)Tc-MIBI group (P&lt;0.05).	RP-30	39-46	thyroglobulin	Homo sapiens	17-19
26929643-7	2016	In addition, the Tg levels in the (99m)Tc-MIBI(+)/(131)I(-) group were significantly higher than that in the (131)I(+)/(99m)Tc-MIBI group (P&lt;0.05).	RP-30	124-131	thyroglobulin	Homo sapiens	17-19
26929643-9	2016	The results of (99m)Tc-MIBI imaging showed good correlations with the Tg level.	RP-30	20-27	thyroglobulin	Homo sapiens	70-72
26909485-1	2016	Thyroglobulin (Tg) is the major glycoprotein produced by the thyroid gland, where it serves as a template for thyroid hormone synthesis and as an intraglandular store of iodine.	Iodine	170-176	thyroglobulin	Homo sapiens	15-17
27904869-10	2016	CONCLUSION: Dedicated head and neck 18F-FDG PET/CT protocol showed a higher diagnostic value, compared to CT scan and played an important role in detecting recurrent or metastatic lesions in post-surgical DTC patients with high serum Tg level and negative 131I WBS.	dtc	205-208	thyroglobulin	Homo sapiens	234-236
26054905-1	2016	A 54-year-old woman who had undergone total thyroidectomy and radioactive iodine treatment for papillary thyroid cancer presented with elevated stimulated thyroglobulin levels and negative I-131 scan.	radioactive iodine	62-80	thyroglobulin	Homo sapiens	155-168
26711165-2	2016	In patients with differentiated thyroid cancer of follicular origin, serum Tg levels become undetectable following total thyroidectomy and iodine-131 remnant ablation.	Iodine	139-145	thyroglobulin	Homo sapiens	75-77
26595189-1	2016	Thyroglobulin (Tg) is a vertebrate secretory protein synthesized in the thyrocyte endoplasmic reticulum (ER), where it acquires N-linked glycosylation and conformational maturation (including formation of many disulfide bonds), leading to homodimerization.	Nitrogen	128-129	thyroglobulin	Homo sapiens	0-13
26595189-1	2016	Thyroglobulin (Tg) is a vertebrate secretory protein synthesized in the thyrocyte endoplasmic reticulum (ER), where it acquires N-linked glycosylation and conformational maturation (including formation of many disulfide bonds), leading to homodimerization.	Disulfides	210-219	thyroglobulin	Homo sapiens	0-13
26153429-4	2016	For iodine-replete females, levels of both TSH and TGN increased with decrease in the levels of both UAB (p &lt; 0.01) and UAS (p &lt; 0.01).	Iodine	4-10	thyroglobulin	Homo sapiens	51-54
26164179-1	2016	PURPOSE: We investigated the potential value of TSH-stimulated serum thyroglobulin (sTg) to characterize subcentimeter-sized, F-FDG avid cervical lymph nodes (LNs) on 18PET/CT and their responsiveness to 131I ablation therapy (IAT) in patients with papillary thyroid cancer.	Thyrotropin	48-51	thyroglobulin	Homo sapiens	69-82
27034856-0	2016	A Case Report of Dramatically Increased Thyroglobulin after Lymph Node Biopsy in Thyroid Carcinoma after Total Thyroidectomy and Radioiodine.	Iodine-131	129-140	thyroglobulin	Homo sapiens	40-53
27034856-1	2016	Thyroglobulin (Tg) is an important modality for monitoring patients with thyroid cancers, especially after thyroidectomy followed by radioiodine (RAI).	Iodine-131	133-144	thyroglobulin	Homo sapiens	0-13
27034856-1	2016	Thyroglobulin (Tg) is an important modality for monitoring patients with thyroid cancers, especially after thyroidectomy followed by radioiodine (RAI).	Iodine-131	133-144	thyroglobulin	Homo sapiens	15-17
26884109-0	2016	Ongoing risk stratification for differentiated thyroid cancer (DTC) - stimulated serum thyroglobulin (Tg) before radioiodine (RAI) ablation, the most potent risk factor of cancer recurrence in M0 patients.	Iodine-131	126-129	thyroglobulin	Homo sapiens	87-100
26153429-4	2016	For iodine-replete females, levels of both TSH and TGN increased with decrease in the levels of both UAB (p &lt; 0.01) and UAS (p &lt; 0.01).	4-methyl-~{N}-(4-phenylbutyl)piperidine-1-carboxamide	101-104	thyroglobulin	Homo sapiens	51-54
26153429-4	2016	For iodine-replete females, levels of both TSH and TGN increased with decrease in the levels of both UAB (p &lt; 0.01) and UAS (p &lt; 0.01).	Phenindione	123-126	thyroglobulin	Homo sapiens	51-54
25393656-0	2015	A low postoperative nonstimulated serum thyroglobulin level excludes the presence of persistent disease in low-risk papillary thyroid cancer patients: implication for radioiodine indication.	Iodine-131	167-178	thyroglobulin	Homo sapiens	40-53
26550046-1	2015	OBJECTIVE: The aim of this study was to evaluate the value of thyroglobulin (Tg) kinetics during preparation of radioiodine ablation for prediction of initial radioiodine ablation failure in thyroid cancer patients.	Iodine-131	112-123	thyroglobulin	Homo sapiens	62-75
26550046-1	2015	OBJECTIVE: The aim of this study was to evaluate the value of thyroglobulin (Tg) kinetics during preparation of radioiodine ablation for prediction of initial radioiodine ablation failure in thyroid cancer patients.	Iodine-131	112-123	thyroglobulin	Homo sapiens	77-79
26550046-1	2015	OBJECTIVE: The aim of this study was to evaluate the value of thyroglobulin (Tg) kinetics during preparation of radioiodine ablation for prediction of initial radioiodine ablation failure in thyroid cancer patients.	Iodine-131	159-170	thyroglobulin	Homo sapiens	62-75
26550046-1	2015	OBJECTIVE: The aim of this study was to evaluate the value of thyroglobulin (Tg) kinetics during preparation of radioiodine ablation for prediction of initial radioiodine ablation failure in thyroid cancer patients.	Iodine-131	159-170	thyroglobulin	Homo sapiens	77-79
26550046-10	2015	CONCLUSIONS: Thyroglobulin kinetics on consecutive blood sampling during hormone withdrawal may be helpful in predicting patients with higher risk of treatment failure of initial radioiodine ablation therapy in thyroid cancer patients.	Iodine-131	179-190	thyroglobulin	Homo sapiens	13-26
26245764-0	2015	Serum thyroglobulin before and after iodization of salt: an 11-year DanThyr follow-up study.	Salts	51-55	thyroglobulin	Homo sapiens	6-19
26528830-1	2015	BACKGROUND: Thyroglobulin (Tg), a biomarker of iodine nutrition, can be measured on dried blood spots (DBS), which simplifies collection and transport in surveys.	Iodine	47-53	thyroglobulin	Homo sapiens	12-25
26528830-1	2015	BACKGROUND: Thyroglobulin (Tg), a biomarker of iodine nutrition, can be measured on dried blood spots (DBS), which simplifies collection and transport in surveys.	dbs	103-106	thyroglobulin	Homo sapiens	12-25
26245764-1	2015	OBJECTIVE: Our objective was to investigate individual serum thyroglobulin (Tg) changes in relation to iodine fortification (IF) and to clarify possible predictors of these changes.	Iodine	103-109	thyroglobulin	Homo sapiens	61-74
25644787-2	2015	Previously, we concluded that persistent exposure to low doses of PCB118 could severely damage the thyroidal structure, dramatically decrease the concentration of serum thyroid hormones and inhibit the pivotal gene expressions such as sodium/iodide symporter (NIS) and thyroglobulin (Tg).	2,3',4,4',5-pentachlorobiphenyl	66-72	thyroglobulin	Homo sapiens	269-282
26579570-0	2015	Melatonin in the thyroid gland: regulation by thyroid-stimulating hormone and role in thyroglobulin gene expression.	Melatonin	0-9	thyroglobulin	Homo sapiens	86-99
26579570-5	2015	Furthermore, exogenous melatonin increases thyroglobulin expression at mRNA and protein levels on cultured thyrocytes and this effect is not strictly mediated by the upregulation of TTF1 or, noteworthy, PAX8 transcription factors.	Melatonin	23-32	thyroglobulin	Homo sapiens	43-56
26579570-7	2015	Additionally, in the present study we show evidence for the involvement of melatonin in thyroid function by directly-regulating thyroglobulin gene expression in follicular cells.	Melatonin	75-84	thyroglobulin	Homo sapiens	128-141
25964171-3	2015	PATIENT FINDINGS: A patient with a history of T3N1b papillary thyroid carcinoma (PTC) previously treated with total thyroidectomy, left central and lateral neck dissection, and radioactive iodine presented with progressive elevations in serum thyroglobulin (Tg) from baseline of 0.2 to 0.6 mug/L.	Iodine	189-195	thyroglobulin	Homo sapiens	243-256
25895485-0	2015	Transient early increase in thyroglobulin levels post-radioiodine ablation in patients with differentiated thyroid cancer.	Iodine-131	54-65	thyroglobulin	Homo sapiens	28-41
26550375-5	2015	Furthermore, CMNa combined with adioiodine treatment significantly increased the percentage of thyroglobulin (Tg) reduction at 12 weeks after treatment (P&lt;0.05).	adioiodine	32-42	thyroglobulin	Homo sapiens	95-108
25980591-1	2015	OBJECTIVE: A diffuse hepatic uptake (DHU) on radioiodine whole-body scans (WBS) after (131)I therapy is caused by (131)I-labeled iodoproteins, particularly (131)I-labeled thyroglobulin (Tg).	1,3-Dicyclohexylurea	37-40	thyroglobulin	Homo sapiens	171-184
25980591-1	2015	OBJECTIVE: A diffuse hepatic uptake (DHU) on radioiodine whole-body scans (WBS) after (131)I therapy is caused by (131)I-labeled iodoproteins, particularly (131)I-labeled thyroglobulin (Tg).	Iodine-131	45-56	thyroglobulin	Homo sapiens	171-184
25998693-2	2015	Here, we determined Tg concentration by isoelectric focusing (IEF) on agarose gel using for detection a rabbit antiserum to human Tg termed FLX.	Sepharose	70-77	thyroglobulin	Homo sapiens	20-22
25998693-6	2015	However, in 5 of the 96 thyroid patients, and none of the 46 healthy subjects, Tg was undetectable by antiserum FLX and measurable by IRMA.	flx	112-115	thyroglobulin	Homo sapiens	79-81
25998693-8	2015	We hypothesize that the decreased binding of FLX to Tg may be the result of conformational change on the Tg molecule, a phenomenon apparently related to immunodeficiency in HIV-infected patients.	flx	45-48	thyroglobulin	Homo sapiens	52-54
25998693-8	2015	We hypothesize that the decreased binding of FLX to Tg may be the result of conformational change on the Tg molecule, a phenomenon apparently related to immunodeficiency in HIV-infected patients.	flx	45-48	thyroglobulin	Homo sapiens	105-107
26558235-10	2015	Among diabetic patients with cervical LN metastasis of DTC, the metformin subgroup (17.1 years) was associated with longer DFS than the nonmetformin subgroup (8.6 years) (HR 0.16, p = 0.021); metformin treatment was also associated with longer DFS in this subgroup in multivariate analysis after adjusting age, BMI, duration of diabetes, presence of tumor at resection margin, and serum thyroglobulin level at ablation (HR 0.03, p = 0.035).	Metformin	64-73	thyroglobulin	Homo sapiens	387-400
25895485-2	2015	Measurement of serum thyroglobulin (Tg) levels is used for assessing disease burden and identifying persistent-recurrent DTC.	dtc	121-124	thyroglobulin	Homo sapiens	21-34
25895485-2	2015	Measurement of serum thyroglobulin (Tg) levels is used for assessing disease burden and identifying persistent-recurrent DTC.	dtc	121-124	thyroglobulin	Homo sapiens	36-38
25895485-5	2015	Stimulation of Tg was achieved by thyroid hormone withdrawal to achieve serum thyroid stimulating hormone (TSH) &gt;=30 mU/L.	Thyrotropin	107-110	thyroglobulin	Homo sapiens	15-17
25524437-15	2015	Diagnostic whole-body iodine scan is indicated when serum anti-thyroglobulin Ab is high, or in cases of discordant findings between US and stimulated thyroglobulin levels, or when stimulated thyroglobulin levels are &gt;10 ng/ml (to evaluate for lung metastasis).	Iodine	22-28	thyroglobulin	Homo sapiens	63-76
25950720-0	2015	Subclinical Hypothyroidism and Elevated Thyroglobulin in Infants with Chronic Excess Iodine Intake.	Iodine	85-91	thyroglobulin	Homo sapiens	40-53
26458613-6	2015	The indicators that should raise the suspicion of false-positive radioiodine uptake to the attending physician include: (a) undetectable/low serum thyroglobulin level (although this may not be always the case, depending on the clinical setting), (b) a well-controlled disease with no other abnormal focus in the rest of the body,	Iodine-131	65-76	thyroglobulin	Homo sapiens	147-160
25763842-0	2015	Serum Thyroglobulin Measured With a Second-Generation Assay in Patients Undergoing Total Thyroidectomy Without Radioiodine Remnant Ablation: A Prospective Study.	Iodine-131	111-122	thyroglobulin	Homo sapiens	6-19
25524437-15	2015	Diagnostic whole-body iodine scan is indicated when serum anti-thyroglobulin Ab is high, or in cases of discordant findings between US and stimulated thyroglobulin levels, or when stimulated thyroglobulin levels are &gt;10 ng/ml (to evaluate for lung metastasis).	Iodine	22-28	thyroglobulin	Homo sapiens	150-163
25524437-15	2015	Diagnostic whole-body iodine scan is indicated when serum anti-thyroglobulin Ab is high, or in cases of discordant findings between US and stimulated thyroglobulin levels, or when stimulated thyroglobulin levels are &gt;10 ng/ml (to evaluate for lung metastasis).	Iodine	22-28	thyroglobulin	Homo sapiens	150-163
24844253-12	2015	CONCLUSION: Based on the retrospective analysis of 86 patients, 18F-FDG SPECT/CT has lower sensitivity in the diagnosis of DTC recurrence with elevated Tg and negative iodine-131scan to 18F-FDG PET/CT.	dtc	123-126	thyroglobulin	Homo sapiens	152-154
26085857-0	2015	Does (131)I Radioactivity Interfere with Thyroglobulin Measurement in Patients Undergoing Radioactive Iodine Therapy with Recombinant Human TSH?	radioactive iodine	90-108	thyroglobulin	Homo sapiens	41-54
25546193-0	2015	Thyroglobulin flare response after radioiodine ablation in 2 patients with differentiated thyroid cancer.	Iodine-131	35-46	thyroglobulin	Homo sapiens	0-13
25546193-2	2015	We describe 2 patients with papillary thyroid cancer who developed dramatic transient serum Tg level elevations within 1 week of I radioiodine (RAI) ablation without cancer recurrence on follow-up.	Iodine-131	131-142	thyroglobulin	Homo sapiens	92-94
25546193-2	2015	We describe 2 patients with papillary thyroid cancer who developed dramatic transient serum Tg level elevations within 1 week of I radioiodine (RAI) ablation without cancer recurrence on follow-up.	Iodine-131	144-147	thyroglobulin	Homo sapiens	92-94
25546193-4	2015	The pre-injection Tg level was 3.8 mug/L and increased to 3060 mug/L 3 days post-RAI.	Iodine-131	81-84	thyroglobulin	Homo sapiens	18-20
25546193-5	2015	In the second patient, the serum Tg level increased from 1.3 mug/L to 209.9 mug/L 7 days after RAI.	Iodine-131	95-98	thyroglobulin	Homo sapiens	33-35
25881600-1	2015	BACKGROUND: Postoperative preablative stimulated thyroglobulin (ps-Tg) has been evaluated in predicting prognosis and success of ablation regarding differentiated thyroid cancer (DTC); however, its relationship with recurrence risk and radioiodine decision-making remains uncertain, especially in Chinese DTC patients.	Iodine-131	236-247	thyroglobulin	Homo sapiens	49-62
25205448-0	2015	Adjuvant therapy with 131-iodine in patients with elevated serum thyroglobulin after reoperation due to papillary thyroid carcinoma lymph node metastases.	Iodine-131	22-32	thyroglobulin	Homo sapiens	65-78
25724214-2	2015	However, some patients have negative radioiodine whole-body scans and detectable serum thyroglobulin with biochemical radioiodine-refractory carcinoma and are candidates for treatment with a multikinase inhibitor, such as sorafenib.	Iodine-131	118-129	thyroglobulin	Homo sapiens	87-100
25724214-2	2015	However, some patients have negative radioiodine whole-body scans and detectable serum thyroglobulin with biochemical radioiodine-refractory carcinoma and are candidates for treatment with a multikinase inhibitor, such as sorafenib.	Sorafenib	222-231	thyroglobulin	Homo sapiens	87-100
25724214-10	2015	CONCLUSIONS: Few patients among thyroglobulin-positive/scan-negative patients are candidates for sorafenib, despite the significant survival differences from double-negative patients.	Sorafenib	97-106	thyroglobulin	Homo sapiens	32-45
25960959-3	2015	Thyroglobulin (Tg) is an important target in iodine-induced autoimmune response due to post-translational modifications of iodinated Tg, as suggested in animal models.	Iodine	45-51	thyroglobulin	Homo sapiens	0-13
25404419-0	2015	Serum thyroglobulin level after radioiodine therapy (Day 3) to predict successful ablation of thyroid remnant in postoperative thyroid cancer.	Iodine-131	32-43	thyroglobulin	Homo sapiens	6-19
25791536-5	2015	Study outcomes were 1) the cumulative dose of radioactive iodine (RAI) to achieve a disease-free state, defined as a stimulated serum thyroglobulin (Tg) level &amp;lt;2 ng/mL with negative Tg antibody and no tumor on a whole-body scan or cross-sectional imaging, and 2) the 5-year serum Tg level.	radioactive iodine	46-64	thyroglobulin	Homo sapiens	134-147
25663898-1	2015	The analysis of serum thyroglobulin (Tg) following thyroid-stimulating hormone (TSH) stimulation (sTg) has been recommended in the follow-up of differentiated thyroid carcinoma (DTC) patients, however, its routine use remains controversial.	Thyrotropin	51-78	thyroglobulin	Homo sapiens	22-35
25663898-1	2015	The analysis of serum thyroglobulin (Tg) following thyroid-stimulating hormone (TSH) stimulation (sTg) has been recommended in the follow-up of differentiated thyroid carcinoma (DTC) patients, however, its routine use remains controversial.	Thyrotropin	51-78	thyroglobulin	Homo sapiens	37-39
25663898-1	2015	The analysis of serum thyroglobulin (Tg) following thyroid-stimulating hormone (TSH) stimulation (sTg) has been recommended in the follow-up of differentiated thyroid carcinoma (DTC) patients, however, its routine use remains controversial.	Thyrotropin	80-83	thyroglobulin	Homo sapiens	22-35
25663898-1	2015	The analysis of serum thyroglobulin (Tg) following thyroid-stimulating hormone (TSH) stimulation (sTg) has been recommended in the follow-up of differentiated thyroid carcinoma (DTC) patients, however, its routine use remains controversial.	Thyrotropin	80-83	thyroglobulin	Homo sapiens	37-39
25404419-3	2015	Levels of TSH-stimulated Tg prior to ablation (stimTg) and serum Tg sampled immediately after RAI therapy (Day 3) were measured (immTg).	Thyrotropin	10-13	thyroglobulin	Homo sapiens	25-27
25720709-1	2015	OBJECTIVE: Fluorodeoxyglucose positron emission tomography/computed tomography imaging in the follow-up of patients with differentiated thyroid carcinoma who have high serum thyroglobulin, negative iodine-131 whole body scan and suppressed thyrotropin.	Fluorodeoxyglucose F18	11-29	thyroglobulin	Homo sapiens	174-187
25287273-2	2015	However, even in cases without these findings presumed to increase the Tg concentration in the previous studies, we previously reported that in some cases the Tg concentration in right heart blood (RHB) and left heart blood (LHB) exceeded the standard value for diagnosis (200 ng/mL) defined in previous studies and the Tg concentration in RHB was significantly higher than that in LHB.	rhb	198-201	thyroglobulin	Homo sapiens	159-161
25679071-1	2015	Fluorine-18-labeled 2-fluoro-2-deoxy-D-glucose positron emission tomography/computerized tomography ((18)F-FDG PET/CT) plays an important role in detecting differentiated thyroid carcinoma (DTC) metastases with elevated thyroglobulin (Tg) and negative radioiodine ((131)I) uptake.	Fluorine-18	0-11	thyroglobulin	Homo sapiens	220-233
25679071-1	2015	Fluorine-18-labeled 2-fluoro-2-deoxy-D-glucose positron emission tomography/computerized tomography ((18)F-FDG PET/CT) plays an important role in detecting differentiated thyroid carcinoma (DTC) metastases with elevated thyroglobulin (Tg) and negative radioiodine ((131)I) uptake.	Fluorodeoxyglucose F18	20-46	thyroglobulin	Homo sapiens	220-233
25569410-8	2015	Thyroglobulin and thyroid transcription factor 1 stains displayed a strong staining on paraffin block.	Paraffin	87-95	thyroglobulin	Homo sapiens	0-13
24832153-0	2015	Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival.	gvax	46-50	thyroglobulin	Homo sapiens	15-28
24832153-2	2015	Considering the paucity of information about thyroid autoimmunity in patients receiving cancer vaccines, we designed our study to assess the development of thyroglobulin antibodies (TgAbs) in patients treated with GVAX (vaccine made of a tumor cell type transfected with GM-CSF) and/or ipilimumab and correlated seroconversion with survival.	gvax	214-218	thyroglobulin	Homo sapiens	156-169
24832153-12	2015	This TgAbs seroconversion could be detected mainly by the in house assay, suggesting that the thyroglobulin epitopes recognized by the antibodies induced by GVAX are different from the epitopes seen in the classic form of Hashimoto thyroiditis.	gvax	157-161	thyroglobulin	Homo sapiens	94-107
25287273-2	2015	However, even in cases without these findings presumed to increase the Tg concentration in the previous studies, we previously reported that in some cases the Tg concentration in right heart blood (RHB) and left heart blood (LHB) exceeded the standard value for diagnosis (200 ng/mL) defined in previous studies and the Tg concentration in RHB was significantly higher than that in LHB.	rhb	198-201	thyroglobulin	Homo sapiens	159-161
25287273-2	2015	However, even in cases without these findings presumed to increase the Tg concentration in the previous studies, we previously reported that in some cases the Tg concentration in right heart blood (RHB) and left heart blood (LHB) exceeded the standard value for diagnosis (200 ng/mL) defined in previous studies and the Tg concentration in RHB was significantly higher than that in LHB.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	225-228	thyroglobulin	Homo sapiens	159-161
25287273-2	2015	However, even in cases without these findings presumed to increase the Tg concentration in the previous studies, we previously reported that in some cases the Tg concentration in right heart blood (RHB) and left heart blood (LHB) exceeded the standard value for diagnosis (200 ng/mL) defined in previous studies and the Tg concentration in RHB was significantly higher than that in LHB.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	225-228	thyroglobulin	Homo sapiens	159-161
25287273-2	2015	However, even in cases without these findings presumed to increase the Tg concentration in the previous studies, we previously reported that in some cases the Tg concentration in right heart blood (RHB) and left heart blood (LHB) exceeded the standard value for diagnosis (200 ng/mL) defined in previous studies and the Tg concentration in RHB was significantly higher than that in LHB.	rhb	340-343	thyroglobulin	Homo sapiens	159-161
25287273-2	2015	However, even in cases without these findings presumed to increase the Tg concentration in the previous studies, we previously reported that in some cases the Tg concentration in right heart blood (RHB) and left heart blood (LHB) exceeded the standard value for diagnosis (200 ng/mL) defined in previous studies and the Tg concentration in RHB was significantly higher than that in LHB.	rhb	340-343	thyroglobulin	Homo sapiens	159-161
25287273-2	2015	However, even in cases without these findings presumed to increase the Tg concentration in the previous studies, we previously reported that in some cases the Tg concentration in right heart blood (RHB) and left heart blood (LHB) exceeded the standard value for diagnosis (200 ng/mL) defined in previous studies and the Tg concentration in RHB was significantly higher than that in LHB.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	382-385	thyroglobulin	Homo sapiens	159-161
25287273-2	2015	However, even in cases without these findings presumed to increase the Tg concentration in the previous studies, we previously reported that in some cases the Tg concentration in right heart blood (RHB) and left heart blood (LHB) exceeded the standard value for diagnosis (200 ng/mL) defined in previous studies and the Tg concentration in RHB was significantly higher than that in LHB.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	382-385	thyroglobulin	Homo sapiens	159-161
25287273-7	2015	Tg is more readily diffused to heart blood (RHB, LHB) than to peripheral blood (IVB, IAB) because of the proximity of the heart to the thyroid gland.	rhb	44-47	thyroglobulin	Homo sapiens	0-2
25287273-7	2015	Tg is more readily diffused to heart blood (RHB, LHB) than to peripheral blood (IVB, IAB) because of the proximity of the heart to the thyroid gland.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	49-52	thyroglobulin	Homo sapiens	0-2
26028188-9	2015	CONCLUSION: Less than four months after 131I ablation is too early to perform radioiodine diagnostic whole body scintigraphy with concurrent TSH stimulated Tg measurement.	Thyrotropin	141-144	thyroglobulin	Homo sapiens	156-158
26396629-0	2014	Stimulated Serum Thyroglobulin Level at the Time of First Dose of Radioactive Iodine Therapy Is the Most Predictive Factor for Therapeutic Failure in Patients With Papillary Thyroid Carcinoma.	radioactive iodine	66-84	thyroglobulin	Homo sapiens	17-30
25536321-0	2015	The relationship between iodine intake and serum thyroglobulin in the general population.	Iodine	25-31	thyroglobulin	Homo sapiens	49-62
25536321-1	2015	The relationship is shown between a concentration of urinary iodine and serum thyroglobulin in population studies carried out on a general population that was randomly selected from the registry of the General Health Insurance Company (individuals aged 6-98 years, 1751 males, 2420 females).	Iodine	61-67	thyroglobulin	Homo sapiens	78-91
25536321-4	2015	Tg concentrations were dependent on gender (males&lt;females), age (thyroglobulin increased with age) and statistically significant negative relationship was observed between thyroglobulin and urinary iodine in individuals with urinary iodine &lt;300 microg/l and the age under 65 years.	Thioguanine	0-2	thyroglobulin	Homo sapiens	68-81
25536321-4	2015	Tg concentrations were dependent on gender (males&lt;females), age (thyroglobulin increased with age) and statistically significant negative relationship was observed between thyroglobulin and urinary iodine in individuals with urinary iodine &lt;300 microg/l and the age under 65 years.	Thioguanine	0-2	thyroglobulin	Homo sapiens	175-188
25536321-4	2015	Tg concentrations were dependent on gender (males&lt;females), age (thyroglobulin increased with age) and statistically significant negative relationship was observed between thyroglobulin and urinary iodine in individuals with urinary iodine &lt;300 microg/l and the age under 65 years.	Iodine	201-207	thyroglobulin	Homo sapiens	175-188
25536321-4	2015	Tg concentrations were dependent on gender (males&lt;females), age (thyroglobulin increased with age) and statistically significant negative relationship was observed between thyroglobulin and urinary iodine in individuals with urinary iodine &lt;300 microg/l and the age under 65 years.	Iodine	236-242	thyroglobulin	Homo sapiens	175-188
25536321-5	2015	Upper nonparametric tolerance limits of thyroglobulin in relation to iodine intake were calculated in subgroup of normal individuals (n=1858, thyroglobulin, urinary iodine, thyrotropin and free thyroxine were within the normal reference range).	Iodine	69-75	thyroglobulin	Homo sapiens	40-53
25536321-8	2015	In general, thyroglobulin serum concentrations higher than 40 microg/l should be an indicator for determining urinary iodine.	Iodine	118-124	thyroglobulin	Homo sapiens	12-25
25120245-1	2014	AIM: In the follow-up of differentiated thyroid cancer (DTC) after a successful total-near total thyroidectomy and I-131 ablation therapy, anti-thyroglobulin antibodies (anti-Tg) may be persistently or progressively increased in the patients with an undetectable serum thyroglobulin (Tg) level.	Iodine	1-2	thyroglobulin	Homo sapiens	144-157
25120245-1	2014	AIM: In the follow-up of differentiated thyroid cancer (DTC) after a successful total-near total thyroidectomy and I-131 ablation therapy, anti-thyroglobulin antibodies (anti-Tg) may be persistently or progressively increased in the patients with an undetectable serum thyroglobulin (Tg) level.	Iodine	1-2	thyroglobulin	Homo sapiens	175-177
25120245-1	2014	AIM: In the follow-up of differentiated thyroid cancer (DTC) after a successful total-near total thyroidectomy and I-131 ablation therapy, anti-thyroglobulin antibodies (anti-Tg) may be persistently or progressively increased in the patients with an undetectable serum thyroglobulin (Tg) level.	Iodine	1-2	thyroglobulin	Homo sapiens	269-282
25120245-1	2014	AIM: In the follow-up of differentiated thyroid cancer (DTC) after a successful total-near total thyroidectomy and I-131 ablation therapy, anti-thyroglobulin antibodies (anti-Tg) may be persistently or progressively increased in the patients with an undetectable serum thyroglobulin (Tg) level.	Iodine	1-2	thyroglobulin	Homo sapiens	284-286
25120245-3	2014	The aim of our study was clarifying the role of FDG-PET/CT in detecting recurrence/metastasis in patients with DTC with negative serum Tg and elevated anti-Tg level.	dtc	111-114	thyroglobulin	Homo sapiens	156-158
25120245-13	2014	CONCLUSION: The value of a persistently or progressively increased serum anti-Tg level in the follow-up of DTC in the prediction of recurrence/metastasis is controversial.	dtc	107-110	thyroglobulin	Homo sapiens	78-80
26396629-12	2014	CONCLUSIONS: A high preablation Tg level is the most significant predictor of therapeutic failure at the time of first HI-Rx in patients with PTC.	hi-rx	119-124	thyroglobulin	Homo sapiens	32-34
24762031-1	2014	BACKGROUND: Thyroglobulin, produced exclusively by the thyroid gland, has been proposed to be a more sensitive biomarker of iodine status than thyrotropin or the thyroid hormones triiodothyronine and thyroxine.	Iodine	124-130	thyroglobulin	Homo sapiens	12-25
25119656-6	2014	SUMMARY: RAI is not administered in many low-risk patients who can be reliably followed up with serum thyroglobulin determination on L-thyroxine treatment and neck ultrasonography.	Thyroxine	133-144	thyroglobulin	Homo sapiens	102-115
25988151-6	2014	The increase of thyroglobulin (TG) levels following thyroid removal referred the patient for radioiodine treatment.	Iodine-131	93-104	thyroglobulin	Homo sapiens	16-29
24820222-0	2014	Do negative 124I pretherapy positron emission tomography scans in patients with elevated serum thyroglobulin levels predict negative 131I posttherapy scans?	Iodine-131	133-137	thyroglobulin	Homo sapiens	95-108
24866576-1	2014	OBJECTIVE: In patients with differentiated thyroid cancer (DTC), the stimulated serum thyroglobulin (Tg) level at radioiodine ablation is a known predictive factor of persistent disease.	Iodine-131	114-125	thyroglobulin	Homo sapiens	86-99
24866576-1	2014	OBJECTIVE: In patients with differentiated thyroid cancer (DTC), the stimulated serum thyroglobulin (Tg) level at radioiodine ablation is a known predictive factor of persistent disease.	Iodine-131	114-125	thyroglobulin	Homo sapiens	101-103
24866576-3	2014	We aimed to assess the impact of both radioiodine preparation modalities and persistent tumor burden on stimulated Tg levels.	Iodine-131	38-49	thyroglobulin	Homo sapiens	115-117
24866576-11	2014	Also, Tg levels were lower in nonstructural disease than in structural disease in both rhTSH (3.8 vs 127.0 ng/ml, P&lt;0.01) and THW (13.0 vs 143.5 ng/ml, P&lt;0.0001) patients.	THW	129-132	thyroglobulin	Homo sapiens	6-8
24866576-13	2014	CONCLUSION: Both radioiodine preparation modalities and the burden of persistent tumor affect the stimulated Tg level at ablation.	Iodine-131	17-28	thyroglobulin	Homo sapiens	109-111
24762031-8	2014	The majority of studies (six of eight) reported that iodine-deficient pregnant women had a median Tg &gt;=13 mug/L.	Iodine	53-59	thyroglobulin	Homo sapiens	98-100
24762031-10	2014	In adults, the results were equivocal because iodine-deficient adults were reported to have median Tg values of either &lt;13 or &gt;=13 mug/L.	Iodine	46-52	thyroglobulin	Homo sapiens	99-101
24762031-11	2014	Only studies in school-aged children showed that iodine-sufficient children typically had a median Tg &lt;13 mug/L.	Iodine	49-55	thyroglobulin	Homo sapiens	99-101
24762031-2	2014	However, evidence on the usefulness of thyroglobulin (Tg) to assess iodine status has not been extensively reviewed, particularly in pregnant women and adults.	Iodine	68-74	thyroglobulin	Homo sapiens	39-52
24762031-2	2014	However, evidence on the usefulness of thyroglobulin (Tg) to assess iodine status has not been extensively reviewed, particularly in pregnant women and adults.	Iodine	68-74	thyroglobulin	Homo sapiens	54-56
24762031-3	2014	SUMMARY: An electronic literature search was conducted using the Cochrane CENTRAL, Web of Science, PubMed, and Medline to locate relevant studies on Tg as a biomarker of iodine status.	Iodine	170-176	thyroglobulin	Homo sapiens	149-151
25050783-5	2014	Although the mechanisms by which iodide induces thyroiditis are still unclear, several mechanisms have been proposed: (1) excess iodine induces the production of cytokines and chemokines that can recruit immunocompetent cells to the thyroid; (2) processing excess iodine in thyroid epithelial cells may result in elevated levels of oxidative stress, leading to harmful lipid oxidation and thyroid tissue injuries; and (3) iodine incorporation in the protein chain of thyroglobulin may augment the antigenicity of this molecule.	Iodine	129-135	thyroglobulin	Homo sapiens	467-480
25246834-0	2014	Clinical determinants of fluorodeoxyglucose positron emission tomography/computed tomography in differentiated thyroid cancer patients with elevated thyroglobulin and negative (131)iodine whole body scans after (131)iodine therapy.	Fluorodeoxyglucose F18	25-43	thyroglobulin	Homo sapiens	149-162
24385210-1	2014	BACKGROUND: Achieving an undetectable serum thyroglobulin (Tg) level (&lt;1.0 ng/mL) after surgical and radioiodine treatment for papillary thyroid cancer (PTC) is associated with low recurrence rates and has been termed biochemical remission.	Iodine-131	104-115	thyroglobulin	Homo sapiens	44-57
24385210-1	2014	BACKGROUND: Achieving an undetectable serum thyroglobulin (Tg) level (&lt;1.0 ng/mL) after surgical and radioiodine treatment for papillary thyroid cancer (PTC) is associated with low recurrence rates and has been termed biochemical remission.	Iodine-131	104-115	thyroglobulin	Homo sapiens	59-61
24565964-6	2014	The Tg concentration of the RHB in 19 (43%) cases and that of the LHB in 10 (23%) cases was higher than the standard value (200ng/ml) obtained in previous studies.	rhb	28-31	thyroglobulin	Homo sapiens	4-6
24997767-9	2014	Preablative and postablative TSH-stimulated thyroglobulin (Tg) and antibodies against thyroglobulin (TgAbs) were measured in both groups, and comparison did not reveal differences.	Thyrotropin	29-32	thyroglobulin	Homo sapiens	44-57
24599957-5	2014	We present evidence suggesting that disulfide maturation occurs within Tg monomers engaged in each of the adduct bands.	Disulfides	36-45	thyroglobulin	Homo sapiens	71-73
24565964-7	2014	In some cases, we found large differences between the Tg concentrations of RHB and LHB.	rhb	75-78	thyroglobulin	Homo sapiens	54-56
24565964-7	2014	In some cases, we found large differences between the Tg concentrations of RHB and LHB.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	83-86	thyroglobulin	Homo sapiens	54-56
24565964-8	2014	We suggest that Tg concentration can increase above the standard value and that a difference between the Tg concentration of RHB and LHB arises as a result of postmortem changes.	rhb	125-128	thyroglobulin	Homo sapiens	105-107
24565964-8	2014	We suggest that Tg concentration can increase above the standard value and that a difference between the Tg concentration of RHB and LHB arises as a result of postmortem changes.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	133-136	thyroglobulin	Homo sapiens	105-107
24565964-9	2014	Consequently, if there is a large difference between the Tg concentration of RHB and LHB, the concentration of Tg should not be used as a basis for forensic diagnosis.	rhb	77-80	thyroglobulin	Homo sapiens	57-59
24599957-6	2014	Moreover, the same Tg substrate molecules can form simultaneous mixed disulfides with both CaBP1/P5 and protein disulfide isomerase, although these are generally viewed as components of distinct oxidoreductase-chaperone protein complexes.	Disulfides	70-80	thyroglobulin	Homo sapiens	19-21
24765241-9	2014	The serum thyroglobulin level was significantly raised (more than 250 ng/mL) with thyroid stimulating hormone being 4.9 muIotaU/mL (even following an adequate period of levothyroxine withdrawal), indicating the functioning nature of the metastases.	Thyroxine	169-182	thyroglobulin	Homo sapiens	10-23
24251883-1	2014	BACKGROUND: The established paradigm for thyroglobulin (Tg) function is that of a high molecular weight precursor of the much smaller thyroid hormones, triiodothyronine (T3) and thyroxine (T4).	Triiodothyronine	152-168	thyroglobulin	Homo sapiens	41-54
24251883-1	2014	BACKGROUND: The established paradigm for thyroglobulin (Tg) function is that of a high molecular weight precursor of the much smaller thyroid hormones, triiodothyronine (T3) and thyroxine (T4).	Triiodothyronine	152-168	thyroglobulin	Homo sapiens	56-58
24251883-1	2014	BACKGROUND: The established paradigm for thyroglobulin (Tg) function is that of a high molecular weight precursor of the much smaller thyroid hormones, triiodothyronine (T3) and thyroxine (T4).	Triiodothyronine	170-172	thyroglobulin	Homo sapiens	41-54
24251883-1	2014	BACKGROUND: The established paradigm for thyroglobulin (Tg) function is that of a high molecular weight precursor of the much smaller thyroid hormones, triiodothyronine (T3) and thyroxine (T4).	Triiodothyronine	170-172	thyroglobulin	Homo sapiens	56-58
24251883-1	2014	BACKGROUND: The established paradigm for thyroglobulin (Tg) function is that of a high molecular weight precursor of the much smaller thyroid hormones, triiodothyronine (T3) and thyroxine (T4).	Thyroxine	178-187	thyroglobulin	Homo sapiens	41-54
24251883-1	2014	BACKGROUND: The established paradigm for thyroglobulin (Tg) function is that of a high molecular weight precursor of the much smaller thyroid hormones, triiodothyronine (T3) and thyroxine (T4).	Thyroxine	178-187	thyroglobulin	Homo sapiens	56-58
24338236-5	2014	We analyzed serum TSH-stimulated thyroglobulin (Tg) and RAI uptake at the time of RAI remnant ablation to compare surgical completeness in the two groups.	Thyrotropin	18-21	thyroglobulin	Homo sapiens	33-46
24338236-8	2014	In subgroup analysis of the robotic group by the period in which operations took place, TSH-stimulated Tg was significantly higher than in the open group in the first (13.28 +- 11.91 ng/ml) and second (10.45 +- 9.30 ng/ml) periods, but there was no significant difference in the third period (6.00 +- 6.26 ng/ml, P = 0.141).	Thyrotropin	88-91	thyroglobulin	Homo sapiens	103-105
24338236-9	2014	The RAI uptake rate at the first RAI ablation did not differ between the two groups, and TSH-stimulated Tg after RAI ablation was similar.	Thyrotropin	89-92	thyroglobulin	Homo sapiens	104-106
24741452-7	2014	Intermediate-risk patients with stimulated thyroglobulin (Tg) levels higher than 2.0 ng/mL showed a greater rate of radioactive iodine uptake on diagnostic WBS.	Iodine	128-134	thyroglobulin	Homo sapiens	43-56
24741452-7	2014	Intermediate-risk patients with stimulated thyroglobulin (Tg) levels higher than 2.0 ng/mL showed a greater rate of radioactive iodine uptake on diagnostic WBS.	Iodine	128-134	thyroglobulin	Homo sapiens	58-60
24067080-0	2014	Is empirical radioactive iodine therapy still a valid approach to patients with thyroid cancer and elevated thyroglobulin?	radioactive iodine	13-31	thyroglobulin	Homo sapiens	108-121
24067080-1	2014	BACKGROUND: At present, empirical radioactive iodine therapy is recommended for patients with thyroid cancer and elevated thyroglobulin (Tg) after initial therapy when neck ultrasonography (US), chest computed tomography (CT), and 18-fluorodeoxyglucose positron emission tomography (FDG-PET) do not reveal metastases.	radioactive iodine	34-52	thyroglobulin	Homo sapiens	122-135
24088547-6	2014	Controlled trials on infant neurodevelopment were lacking; gestational iodine supplementation reduced maternal thyroid volume and serum thyroglobulin and in some studies prevented a rise in serum thyroid-stimulating hormone.	Iodine	71-77	thyroglobulin	Homo sapiens	136-149
24264462-0	2013	Molecular assembly of thyroglobulin induced by in vitro nitric oxide treatments: implication its role in thyroid cells.	Nitric Oxide	56-68	thyroglobulin	Homo sapiens	22-35
24264462-3	2013	Here, we investigated the protein assembly that occur in thyroglobulin under mildly acidic conditions in the presence of nitric oxide.	Nitric Oxide	121-133	thyroglobulin	Homo sapiens	57-70
24264462-4	2013	Solution studies, size exclusion chromatography, dynamic light scattering and analytical ultracentrifugation, demonstrated the size changes of thyroglobulin oligomers after nitric oxide treatment.	Nitric Oxide	173-185	thyroglobulin	Homo sapiens	143-156
24037891-2	2013	OBJECTIVES: Our objectives were to determine whether stimulated Tg levels, measured at the time of remnant ablation performed under recombinant human TSH (rhTSH) stimulation, has value in predicting absence of detectable disease 1 year after radioiodine therapy and to compare the results obtained with this approach with a cohort of patients submitted to ablation after THW.	Thyrotropin	150-153	thyroglobulin	Homo sapiens	64-66
24037891-2	2013	OBJECTIVES: Our objectives were to determine whether stimulated Tg levels, measured at the time of remnant ablation performed under recombinant human TSH (rhTSH) stimulation, has value in predicting absence of detectable disease 1 year after radioiodine therapy and to compare the results obtained with this approach with a cohort of patients submitted to ablation after THW.	Iodine-131	242-253	thyroglobulin	Homo sapiens	64-66
24037891-11	2013	In the THW group, Tg at ablation also proved to have independent predictive value.	THW	7-10	thyroglobulin	Homo sapiens	18-20
24037891-12	2013	Using the same threshold (7.2 ng/mL), the negative predictive value of Tg was 95% in the THW group.	THW	89-92	thyroglobulin	Homo sapiens	71-73
23826916-2	2014	We hypothesized that Tg stimulated after surgery and immediately before radioiodine treatment (baseline-stimulated Tg) could be a good predictor of remission at 18-24 months.	Iodine-131	72-83	thyroglobulin	Homo sapiens	115-117
24761858-0	2014	Importance of postoperative stimulated thyroglobulin level at the time of 131I ablation therapy for differentiated thyroid cancer.	Iodine-131	74-78	thyroglobulin	Homo sapiens	39-52
24761858-1	2014	BACKGROUND: Serum thyroglobulin detection plays an essential role during the follow-up of thyroid cancer patients treated with total/near total thyroidectomy and radioiodine ablation.	Iodine-131	162-173	thyroglobulin	Homo sapiens	18-31
24761858-11	2014	In 9 of 11 patients with metastases (81.8%), stimulated serum Tg level at the time of radioiodine ablation therapy was over 10, however in 1 patient (9.1%) it was &lt; 2 ng/mL and in one patient it was 2-10 ng/mL (p = 0.005).	Iodine-131	86-97	thyroglobulin	Homo sapiens	62-64
24064687-0	2013	Iodine contributes to thyroid autoimmunity in humans by unmasking a cryptic epitope on thyroglobulin.	Iodine	0-6	thyroglobulin	Homo sapiens	87-100
24064687-2	2013	OBJECTIVE: Our aim was to correlate iodine intake, thyroid autoimmunity, and recognition of thyroglobulin (Tg) epitopes after implementation of iodine prophylaxis.	Iodine	144-150	thyroglobulin	Homo sapiens	92-105
23846819-2	2013	OBJECTIVE: To determine the prevalence of thyroid disorders in pregnant women in Belgium and to assess the association between iodine status and serum thyroglobulin (Tg).	Iodine	127-133	thyroglobulin	Homo sapiens	151-164
23939918-0	2013	Ultrasensitive serum thyroglobulin measurement is useful for the follow-up of patients treated with total thyroidectomy without radioactive iodine ablation.	radioactive iodine	128-146	thyroglobulin	Homo sapiens	21-34
24053974-10	2013	Iodine deficiency was associated with increased levels of TSH, TT3, TT4, and TGN.	Iodine	0-6	thyroglobulin	Homo sapiens	77-80
24847452-9	2013	Thyroglobulin (Tg) of iodine group remained stable, contrasting with the rise in the control group.	Iodine	22-28	thyroglobulin	Homo sapiens	0-13
23517405-0	2013	18-fluorodeoxyglucose positron emission tomography in the early diagnostic workup of differentiated thyroid cancer patients with a negative post-therapeutic iodine scan and detectable thyroglobulin.	18-fluorodeoxyglucose	0-21	thyroglobulin	Homo sapiens	184-197
24137351-1	2013	The present study was designed to investigate the association between response evaluation criteria in solid tumors (RECIST) 1.1 and 1.0, and to explore the utility of thyroglobulin (Tg) measurements in assessing tumor responses to sorafenib in patients with radioactive iodine (RAI)-refractory differentiated thyroid carcinoma (DTC).	Sorafenib	231-240	thyroglobulin	Homo sapiens	167-180
23820763-8	2013	Negative early/positive late TxWBS results in patients were found to be significantly correlated (P=0.007) with elevated serum levels of Tg and a high-risk for recurrence (P=0.003).	txwbs	29-34	thyroglobulin	Homo sapiens	137-139
23820763-10	2013	High-risk patients with elevated serum Tg levels should be considered for a late TxWBS, which can demonstrate a possible metastatic involvement that was not diagnosed or that was downstaged by early TxWBS.	txwbs	81-86	thyroglobulin	Homo sapiens	39-41
24024368-1	2013	OBJECTIVE: To deduce normal ranges of thyroglobulin of total population in iodine-replete region by determining the human serum thyroglobulin in normal population of part full iodine region.	Iodine	75-81	thyroglobulin	Homo sapiens	38-51
23190420-1	2013	OBJECTIVE: Serum thyroglobulin (Tg) has been associated with a number of thyroid disorders and has been proposed as an indicator of iodine deficiency in a population.	Iodine	132-138	thyroglobulin	Homo sapiens	17-30
23190420-1	2013	OBJECTIVE: Serum thyroglobulin (Tg) has been associated with a number of thyroid disorders and has been proposed as an indicator of iodine deficiency in a population.	Iodine	132-138	thyroglobulin	Homo sapiens	32-34
23584460-9	2013	In contrast, the distribution of postoperative Tg levels in the macroscopic ETE group was significantly higher than in the other groups (p &lt; 0.001).	ete	76-79	thyroglobulin	Homo sapiens	47-49
23190420-3	2013	Our objective was to evaluate baseline levels of Tg in relation to sociodemographic characteristics, iodine status and thyroid function for individuals exposed to I-131.	Iodine	101-107	thyroglobulin	Homo sapiens	49-51
23190420-3	2013	Our objective was to evaluate baseline levels of Tg in relation to sociodemographic characteristics, iodine status and thyroid function for individuals exposed to I-131.	Iodine-131	163-168	thyroglobulin	Homo sapiens	49-51
23190420-8	2013	RESULTS: In the fully adjusted model, percent change in Tg was significantly increased among females, smokers and subjects of older age and Tg increased with decreasing urinary iodine concentration, increasing serum TSH and increasing thyroid volume (P-values for trend &lt;0 0001), and presence of thyroid nodules (P &lt; 0 05).	Iodine	177-183	thyroglobulin	Homo sapiens	56-58
23190420-8	2013	RESULTS: In the fully adjusted model, percent change in Tg was significantly increased among females, smokers and subjects of older age and Tg increased with decreasing urinary iodine concentration, increasing serum TSH and increasing thyroid volume (P-values for trend &lt;0 0001), and presence of thyroid nodules (P &lt; 0 05).	Iodine	177-183	thyroglobulin	Homo sapiens	140-142
23190420-8	2013	RESULTS: In the fully adjusted model, percent change in Tg was significantly increased among females, smokers and subjects of older age and Tg increased with decreasing urinary iodine concentration, increasing serum TSH and increasing thyroid volume (P-values for trend &lt;0 0001), and presence of thyroid nodules (P &lt; 0 05).	Thyrotropin	216-219	thyroglobulin	Homo sapiens	56-58
23190420-8	2013	RESULTS: In the fully adjusted model, percent change in Tg was significantly increased among females, smokers and subjects of older age and Tg increased with decreasing urinary iodine concentration, increasing serum TSH and increasing thyroid volume (P-values for trend &lt;0 0001), and presence of thyroid nodules (P &lt; 0 05).	Thyrotropin	216-219	thyroglobulin	Homo sapiens	140-142
23190420-10	2013	CONCLUSIONS: In residents of Belarus, serum Tg is significantly related to presence of thyroid abnormalities as well as indicators of thyroid function and iodine deficiency and, therefore, could be used to characterize the iodine status and thyroid function of individuals in the context of epidemiological study.	Iodine	155-161	thyroglobulin	Homo sapiens	44-46
23190420-10	2013	CONCLUSIONS: In residents of Belarus, serum Tg is significantly related to presence of thyroid abnormalities as well as indicators of thyroid function and iodine deficiency and, therefore, could be used to characterize the iodine status and thyroid function of individuals in the context of epidemiological study.	Iodine	223-229	thyroglobulin	Homo sapiens	44-46
23455760-1	2013	UNLABELLED: Congenital hypothyroidism (CH) due to thyroglobulin (TG) deficit is an autosomal recessive disease (OMIM #274700) characterized by hypothyroidism, goiter, low serum TG, and a negative perchlorate discharge test.	perchlorate	196-207	thyroglobulin	Homo sapiens	50-63
23455760-1	2013	UNLABELLED: Congenital hypothyroidism (CH) due to thyroglobulin (TG) deficit is an autosomal recessive disease (OMIM #274700) characterized by hypothyroidism, goiter, low serum TG, and a negative perchlorate discharge test.	perchlorate	196-207	thyroglobulin	Homo sapiens	65-67
24024368-0	2013	[Study on normal ranges of thyroglobulin of total population in iodine-replete region of China].	Iodine	64-70	thyroglobulin	Homo sapiens	27-40
24024368-1	2013	OBJECTIVE: To deduce normal ranges of thyroglobulin of total population in iodine-replete region by determining the human serum thyroglobulin in normal population of part full iodine region.	Iodine	176-182	thyroglobulin	Homo sapiens	128-141
23567283-0	2013	Sustained and diffuse 131I avid bone metastases with low thyroglobulin levels in a patient with papillary thyroid carcinoma.	Iodine-131	22-26	thyroglobulin	Homo sapiens	57-70
23396140-6	2013	A Tg-specific tryptic peptide was purified by immunoaffinity extraction and analyzed by 2-dimensional LC-MS/MS.	Peptides	22-29	thyroglobulin	Homo sapiens	2-4
23463330-4	2013	Consecutive serum Tg measurements performed before the (18)F-FDG PET/CT examination were used for Tg-DT calculation.	Thymidine	101-103	thyroglobulin	Homo sapiens	98-100
23463330-10	2013	CONCLUSION: The accuracy of (18)F-FDG PET/CT significantly improves when the serum Tg level is above 5.5 ng/mL during levothyroxine treatment or when the Tg-DT is less than 1 year, independent of the absolute value.	Thyroxine	118-131	thyroglobulin	Homo sapiens	83-85
23463330-10	2013	CONCLUSION: The accuracy of (18)F-FDG PET/CT significantly improves when the serum Tg level is above 5.5 ng/mL during levothyroxine treatment or when the Tg-DT is less than 1 year, independent of the absolute value.	tg-dt	154-159	thyroglobulin	Homo sapiens	83-85
23489940-0	2013	Postoperative-stimulated serum thyroglobulin measured at the time of 131I ablation is useful for the prediction of disease status in patients with differentiated thyroid carcinoma.	Iodine-131	69-73	thyroglobulin	Homo sapiens	31-44
23489940-8	2013	CONCLUSION: Postoperative-stimulated Tg at the time of (131)I remnant ablation is a useful biochemical marker for the prediction of disease status in patients with DTC.	dtc	164-167	thyroglobulin	Homo sapiens	37-39
23164529-9	2013	In conclusion, our results confirm the genetic heterogeneity of TG defects and the pathophysiological importance of altered TG folding as a consequency of truncated TG proteins and missense mutations located in ACHE-like domain or that replace cysteine.	Cysteine	244-252	thyroglobulin	Homo sapiens	124-126
23067402-1	2013	BACKGROUND: Postsurgical thyrotropin (TSH)-stimulated serum thyroglobulin (Tg) level can be used to predict the likelihood of finding radioactive iodine (RAI) avid metastatic foci on postablation scanning.	radioactive iodine	134-152	thyroglobulin	Homo sapiens	60-73
23067402-1	2013	BACKGROUND: Postsurgical thyrotropin (TSH)-stimulated serum thyroglobulin (Tg) level can be used to predict the likelihood of finding radioactive iodine (RAI) avid metastatic foci on postablation scanning.	Insulin, Short-Acting	154-157	thyroglobulin	Homo sapiens	60-73
22978687-1	2013	BACKGROUND: The thyrotropin (TSH) level or duration of thyroid hormone withdrawal (THW) required to detect stimulated thyroglobulin (Tg) in differentiated thyroid cancer (DTC) monitoring is unknown.	THW	83-86	thyroglobulin	Homo sapiens	118-131
23444413-0	2013	Thyroglobulin in smoking mothers and their newborns at delivery suggests autoregulation of placental iodide transport overcoming thiocyanate inhibition.	Iodides	101-107	thyroglobulin	Homo sapiens	0-13
23444413-0	2013	Thyroglobulin in smoking mothers and their newborns at delivery suggests autoregulation of placental iodide transport overcoming thiocyanate inhibition.	thiocyanate	129-140	thyroglobulin	Homo sapiens	0-13
23345097-0	2013	Thyroglobulin is a sensitive measure of both deficient and excess iodine intakes in children and indicates no adverse effects on thyroid function in the UIC range of 100-299 mug/L: a UNICEF/ICCIDD study group report.	Iodine	66-72	thyroglobulin	Homo sapiens	0-13
23345097-3	2013	Thyroglobulin (Tg) may be a promising functional biomarker of both iodine deficiency and excess.	Iodine	67-73	thyroglobulin	Homo sapiens	0-13
23345097-3	2013	Thyroglobulin (Tg) may be a promising functional biomarker of both iodine deficiency and excess.	Iodine	67-73	thyroglobulin	Homo sapiens	15-17
23345097-4	2013	OBJECTIVES: Using a standardized dried blood spots-Tg assay in children, we evaluated the Tg response to both low- and high-iodine intake and estimated the population cutoff point for iodine deficiency or excess.	Iodine	124-130	thyroglobulin	Homo sapiens	90-92
23345097-9	2013	RESULTS: Over a range of iodine intakes from severely deficient to excessive, Tg concentrations showed a clear U-shaped curve.	Iodine	25-31	thyroglobulin	Homo sapiens	78-80
23345097-10	2013	Compared with iodine-sufficient children, there was a significantly higher prevalence of elevated Tg values in children with iodine deficiency (UIC &lt;100 mug/L) and iodine excess (UIC &gt;300 mug/L).	Iodine	14-20	thyroglobulin	Homo sapiens	98-100
23345097-10	2013	Compared with iodine-sufficient children, there was a significantly higher prevalence of elevated Tg values in children with iodine deficiency (UIC &lt;100 mug/L) and iodine excess (UIC &gt;300 mug/L).	Iodine	125-131	thyroglobulin	Homo sapiens	98-100
23158181-1	2012	BACKGROUND: The efficacy of radioactive iodine therapy (RAI) in patients who have an undetectable thyroglobulin (Tg) level after total thyroidectomy in well-differentiated papillary thyroid cancer (PTC) is questionable.	radioactive iodine	28-46	thyroglobulin	Homo sapiens	98-111
24186588-10	2013	The average level of Tg and iodine uptake after radicalisation was lower in Group I (Nav) than in Group II (3.32 +- 2.09 v. 4.58 +- 2.5 ng/mL, respectively, for Tg [p = 0.021] and 6.29 +- 3.38 v. 7.31 +- 2.29 ng/mL, respectively, for iodine uptake [p = 0.187]).	NAV	85-88	thyroglobulin	Homo sapiens	21-23
23067330-1	2012	BACKGROUND: Iodine-131 ((131)I) total-body scintigraphy is a commonly used post-thyroidectomy imaging procedure in the management of differentiated thyroid cancer (DTC), in particular in patients with an intermediate or high risk of persistent or recurrent disease, in combination with serum thyroglobulin (Tg) determinations and ultrasonography of the neck.	Iodine-131	12-22	thyroglobulin	Homo sapiens	292-305
23067330-1	2012	BACKGROUND: Iodine-131 ((131)I) total-body scintigraphy is a commonly used post-thyroidectomy imaging procedure in the management of differentiated thyroid cancer (DTC), in particular in patients with an intermediate or high risk of persistent or recurrent disease, in combination with serum thyroglobulin (Tg) determinations and ultrasonography of the neck.	Iodine-131	12-22	thyroglobulin	Homo sapiens	307-309
23050786-0	2012	Postoperative stimulated thyroglobulin of less than 1 ng/ml as a criterion to spare low-risk patients with papillary thyroid cancer from radioactive iodine ablation.	radioactive iodine	137-155	thyroglobulin	Homo sapiens	25-38
23166885-5	2012	Mean serum Tg levels after TSH stimulation were 1.57 +- 3.17 and 3.95 +- 10.14 ng/mL in the HS and CT groups, respectively, with significant between-group differences (P = 0.028).	hassio	92-94	thyroglobulin	Homo sapiens	11-13
23166885-5	2012	Mean serum Tg levels after TSH stimulation were 1.57 +- 3.17 and 3.95 +- 10.14 ng/mL in the HS and CT groups, respectively, with significant between-group differences (P = 0.028).	ct	99-101	thyroglobulin	Homo sapiens	11-13
23050786-1	2012	BACKGROUND: Stimulated thyroglobulin (Tg) &lt;=1 ng/mL after thyroidectomy (after L-thyroxine [L-T4] withdrawal or administration of recombinant human thyrotropin [rhTSH]) has been proposed as a criterion to spare patients with papillary thyroid cancer (PTC), who are at low risk of recurrence, from ablation with iodine-131 ((131)I).	Iodine-131	314-324	thyroglobulin	Homo sapiens	23-36
22791761-9	2012	Radioiodine-avid disease appears more amenable to cure, with 81% of patients achieving negative stimulated Tg after repeat I131 treatment and radio-assisted surgery.	Iodine-131	0-11	thyroglobulin	Homo sapiens	107-109
22576067-1	2012	BACKGROUND: In the follow-up of papillary thyroid cancer (PTC) patients treated with curative thyroidectomy and radioiodine ablation, raised thyroglobulin (Tg) predicts recurrence with reasonable sensitivity and specificity.	Iodine-131	112-123	thyroglobulin	Homo sapiens	141-154
22576067-1	2012	BACKGROUND: In the follow-up of papillary thyroid cancer (PTC) patients treated with curative thyroidectomy and radioiodine ablation, raised thyroglobulin (Tg) predicts recurrence with reasonable sensitivity and specificity.	Iodine-131	112-123	thyroglobulin	Homo sapiens	156-158
22791761-13	2012	In radioiodine-negative patients, there may be a higher likelihood of biochemical cure for those with lower preoperative detectable Tg levels.	Iodine-131	3-14	thyroglobulin	Homo sapiens	132-134
22780333-3	2012	METHODS: Serum Tg concentrations in patients with differentiated thyroid cancer, who had been thyroidectomized (Tx), received RAI-RA, and who were receiving levothyroxine to suppress serum thyrotropin (suppressed serum Tg), were retrospectively analyzed.	Thyroxine	157-170	thyroglobulin	Homo sapiens	15-17
22889978-5	2012	Three months after intravenous steroid therapy, the concentrations of thyroglobulin and thyroid peroxidase antibodies were retested and found to have decreased considerably.	Steroids	31-38	thyroglobulin	Homo sapiens	70-83
22853728-0	2012	Postradioiodine treatment whole-body scan in the era of 18-fluorodeoxyglucose positron emission tomography for differentiated thyroid carcinoma with elevated serum thyroglobulin levels.	postradioiodine	0-15	thyroglobulin	Homo sapiens	164-177
22853728-0	2012	Postradioiodine treatment whole-body scan in the era of 18-fluorodeoxyglucose positron emission tomography for differentiated thyroid carcinoma with elevated serum thyroglobulin levels.	18-fluorodeoxyglucose	56-77	thyroglobulin	Homo sapiens	164-177
22780333-3	2012	METHODS: Serum Tg concentrations in patients with differentiated thyroid cancer, who had been thyroidectomized (Tx), received RAI-RA, and who were receiving levothyroxine to suppress serum thyrotropin (suppressed serum Tg), were retrospectively analyzed.	Thyroxine	157-170	thyroglobulin	Homo sapiens	219-221
22780333-7	2012	RESULTS: The nadir -suppressed serum Tg was achieved by 6 months in 58% of the patients and by 12 months in 75% of the patients.	nadir	13-18	thyroglobulin	Homo sapiens	37-39
22780573-1	2012	BACKGROUND: Measurement of the serum thyroglobulin (Tg) level with TSH stimulation (sTg) is the cornerstone of monitoring for the recurrence or persistence of differentiated thyroid cancer (DTC) in patients who have undergone surgery and remnant ablation.	Thyrotropin	67-70	thyroglobulin	Homo sapiens	37-50
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	125-131	thyroglobulin	Homo sapiens	203-216
22663550-0	2012	Undetectable serum thyroglobulin levels in patients with medullary thyroid carcinoma after total thyroidectomy without radioiodine ablation.	Iodine-131	119-130	thyroglobulin	Homo sapiens	19-32
22498723-8	2012	The cotransduction of TTF-1 and Pax-8 gene, with resulting NIS-mediated radioiodine accumulation and TPO and Tg-mediated radioiodine organification and intracellular retention, may lead to effective radioiodine therapy of thyroid carcinoma.	Iodine-131	121-132	thyroglobulin	Homo sapiens	109-111
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodine-131	272-283	thyroglobulin	Homo sapiens	203-216
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodine-131	272-283	thyroglobulin	Homo sapiens	218-220
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	179-185	thyroglobulin	Homo sapiens	218-220
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	179-185	thyroglobulin	Homo sapiens	218-220
22498723-8	2012	The cotransduction of TTF-1 and Pax-8 gene, with resulting NIS-mediated radioiodine accumulation and TPO and Tg-mediated radioiodine organification and intracellular retention, may lead to effective radioiodine therapy of thyroid carcinoma.	Iodine-131	121-132	thyroglobulin	Homo sapiens	109-111
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Iodides	125-131	thyroglobulin	Homo sapiens	218-220
22498723-1	2012	Cotransfer of thyroid-specific transcription factor (TTF)-1 and Pax-8 gene to tumor cells, resulting in the re-expression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to non-iodide-concentrating tumor because the expression of iodide metabolism-associated proteins in thyroid are mediated by the thyroid transcription factor TTF-1 and Pax-8.	Sodium Iodide	172-185	thyroglobulin	Homo sapiens	218-220
21833035-5	2012	Although the NIS mRNA was not detected, the expression of mRNA and proteins of Tg and TPO in AdPax-8-infected F133 cells were activated by Pax-8.	adpax-8	93-100	thyroglobulin	Homo sapiens	79-81
21850699-1	2012	BACKGROUND: The purpose of this study was to assess the relationship between [(18) F]-fluorodeoxyglucose ((18) FDG)-positron emission tomography/CT ((18) FDG-PET/CT) and serum thyroglobulin (Tg) in patients with recurrent differentiated thyroid carcinoma (DTC).	Fluorodeoxyglucose F18	77-104	thyroglobulin	Homo sapiens	176-189
21850699-1	2012	BACKGROUND: The purpose of this study was to assess the relationship between [(18) F]-fluorodeoxyglucose ((18) FDG)-positron emission tomography/CT ((18) FDG-PET/CT) and serum thyroglobulin (Tg) in patients with recurrent differentiated thyroid carcinoma (DTC).	Fluorodeoxyglucose F18	77-104	thyroglobulin	Homo sapiens	191-193
21850699-8	2012	CONCLUSION: Although (18) FDG-PET/CT scans are more likely to be positive with pretest Tg levels &gt;=4.6 ng/mL, 11% of patients with DTC with a lower serum Tg level will still have a positive scan.	dtc	134-137	thyroglobulin	Homo sapiens	87-89
21850699-8	2012	CONCLUSION: Although (18) FDG-PET/CT scans are more likely to be positive with pretest Tg levels &gt;=4.6 ng/mL, 11% of patients with DTC with a lower serum Tg level will still have a positive scan.	dtc	134-137	thyroglobulin	Homo sapiens	157-159
22445893-0	2012	Thyroglobulin (Tg) activates MAPK pathway to induce thyroid cell growth in the absence of TSH, insulin and serum.	Thyrotropin	90-93	thyroglobulin	Homo sapiens	15-17
22445893-2	2012	However, we recently reported that thyroglobulin (Tg), a major product of the thyroid, also induces the growth of thyroid cells cultured in 0.2% serum in the absence of TSH and insulin.	Thyrotropin	169-172	thyroglobulin	Homo sapiens	35-48
22445893-2	2012	However, we recently reported that thyroglobulin (Tg), a major product of the thyroid, also induces the growth of thyroid cells cultured in 0.2% serum in the absence of TSH and insulin.	Thyrotropin	169-172	thyroglobulin	Homo sapiens	50-52
22445893-4	2012	The MEK-1/2 inhibitor PD98059 suppressed Tg-induced phosphorylation of ERK1/2 and reduced bromodeoxyuridine (BrdU) incorporation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	22-29	thyroglobulin	Homo sapiens	41-43
22445893-4	2012	The MEK-1/2 inhibitor PD98059 suppressed Tg-induced phosphorylation of ERK1/2 and reduced bromodeoxyuridine (BrdU) incorporation.	Bromodeoxyuridine	90-107	thyroglobulin	Homo sapiens	41-43
22445893-4	2012	The MEK-1/2 inhibitor PD98059 suppressed Tg-induced phosphorylation of ERK1/2 and reduced bromodeoxyuridine (BrdU) incorporation.	Bromodeoxyuridine	109-113	thyroglobulin	Homo sapiens	41-43
22445893-6	2012	The present results, together with the previous report, suggest that Tg utilizes multiple signaling cascades to induce thyroid cell growth independent of TSH/cAMP stimulation.	Thyrotropin	154-157	thyroglobulin	Homo sapiens	69-71
22614210-9	2012	The mean serum Tg level markedly declined further by 67.4% (range, 37.1%-90.2%) after repeated radioiodine therapy.	Iodine-131	95-106	thyroglobulin	Homo sapiens	15-17
22067268-3	2012	The recommended post-surgical follow-up of these patients is based upon periodical measurements of serum thyroglobulin (Tg) on levothyroxine therapy and neck ultrasound (US).	Thyroxine	127-140	thyroglobulin	Homo sapiens	105-118
22067268-3	2012	The recommended post-surgical follow-up of these patients is based upon periodical measurements of serum thyroglobulin (Tg) on levothyroxine therapy and neck ultrasound (US).	Thyroxine	127-140	thyroglobulin	Homo sapiens	120-122
22067268-10	2012	All the UP and 4/5 formerly DP patients showed undetectable Tg stimulation.	dp	28-30	thyroglobulin	Homo sapiens	60-62
21497873-8	2012	The stimulated Tg levels in the 2 groups became similar, however, after low-dose radioactive iodine treatment (0.44 ng/mL vs. 0.69 ng/mL, respectively; P = 0.341).	Iodine	93-99	thyroglobulin	Homo sapiens	15-17
22324291-2	2012	The labeling of myoglobin (17 kDa), transferrin (77 kDa), and thyroglobulin (670 kDa) proteins was accomplished in a single-step reaction with a commercially available bis(2,2"-bipyridine)-4"-methyl-4-carboxybipyridine-ruthenium N-succinimidyl ester-bis(hexafluorophosphate) (Ru-NHS ester).	ru-nhs ester	276-288	thyroglobulin	Homo sapiens	62-75
22170797-7	2012	RESULTS: Serum TG was the highest among hunters (P = 0.009) and settlement dwellers (P = 0.001), who were most markedly exposed to cold, even though they had the highest urinary iodine excretion (hunters, P &lt; 0.001; settlement dwellers, P &lt; 0.001).	Iodine	178-184	thyroglobulin	Homo sapiens	15-17
24900030-8	2012	Radioactive iodine ablation therapy was considered successful when follow-up (123)I whole body scan was negative and stimulated serum thyroglobulin level was less than 2.0 ng/mL.	radioactive iodine	0-18	thyroglobulin	Homo sapiens	134-147
21950769-9	2012	The independent predictors of survival were younger age, surgical dissection of neck lymph nodes (LNs) and low TSH-stimulated Tg level (&lt;400 mug/l) at the discovery of metastasis.	Thyrotropin	111-114	thyroglobulin	Homo sapiens	126-128
21497873-11	2012	CONCLUSION: With prophylactic CLND, the postoperative Tg level can significantly decrease.	clnd	30-34	thyroglobulin	Homo sapiens	54-56
23607201-2	2012	The aim of this study was to evaluate the relation between Tg level estimated on the third week after thyroidectomy and clinic-pathologic characteristics of DTC as a possible prognostic criterion used to mark the patients with radioiodine therapy indications.	Iodine-131	227-238	thyroglobulin	Homo sapiens	59-61
21971605-13	2012	CONCLUSION: Diagnostic accuracy of FDG PET in radioiodine negative thyroid cancer may vary depending on serum Tg levels at imaging.	Iodine-131	46-57	thyroglobulin	Homo sapiens	110-112
22773156-6	2012	The serum Tg level was measured under TSH stimulation prior to imaging.	Thyrotropin	38-41	thyroglobulin	Homo sapiens	10-12
22773156-9	2012	The results demonstrated that the range of predicted tumour mass was higher per serum Tg unit for iodine-positive lesions than for FDG-positive tumour lesions and was higher for follicular than for papillary thyroid carcinoma.	Iodine	98-104	thyroglobulin	Homo sapiens	86-88
22773156-10	2012	CONCLUSION: This study provides an approach to estimate the tumour mass and its 95% confidence intervals in DTC patients using the serum Tg level.	dtc	108-111	thyroglobulin	Homo sapiens	137-139
22784463-6	2012	Analysis of the TG gene of the affected twin revealed a compound heterozygous mutation, including a novel missense mutation G2687A, which is predicted to result in a glutamine to arginine substitution at codon 877, and a known nonsense mutation C7006T, predicted to result in an arginine to stop codon at codon 2317.	Arginine	179-187	thyroglobulin	Homo sapiens	16-18
22934199-2	2012	A 21-year-old Japanese man treated with levothyroxine for congenital hypothyroidism had an enlarged thyroid gland with undetectable serum thyroglobulin despite elevated serum TSH level.	Thyroxine	40-53	thyroglobulin	Homo sapiens	138-151
23050172-11	2012	Forty-three months following treatment with RAI, she has experienced complete resolution of her symptoms and continues to maintain persistently low-thyroglobulin levels of less than 100 ng/mL.	Insulin, Short-Acting	44-47	thyroglobulin	Homo sapiens	148-161
22814366-0	2012	Serum thyroglobulin level measured after thyroxine withdrawal is useful to predict further recurrence in whole body scan-negative papillary thyroid cancer patients after reoperation.	Thyroxine	41-50	thyroglobulin	Homo sapiens	6-19
23607201-6	2012	The postoperative level of Tg as TTM coefficient (ratio of postoperative Tg to daily L-thyroxin dose in mcg to body weight in kg) was higher in patients with unfavorable prognosis: (a) capsular invasion, (b) cervical lymph nodes metastases, (c) advanced disease stage, (d) high risk of recurrence.	Thyroxine	85-95	thyroglobulin	Homo sapiens	27-29
23607201-9	2012	Finally, the serum Tg level on the third week after thyroidectomy is a valuable prognostic criterion and can be used in DTC to determine the radioiodine therapy indications.	Iodine-131	141-152	thyroglobulin	Homo sapiens	19-21
22064080-1	2011	PURPOSE: Recent studies have shown that thyroglobulin (Tg) concentration is a useful tumor marker in follow-up of differentiated thyroid cancer (DTC) patients after thyroidectomy and subsequent radioiodine (I-131) therapy.	Iodine-131	194-205	thyroglobulin	Homo sapiens	40-53
22064080-1	2011	PURPOSE: Recent studies have shown that thyroglobulin (Tg) concentration is a useful tumor marker in follow-up of differentiated thyroid cancer (DTC) patients after thyroidectomy and subsequent radioiodine (I-131) therapy.	Iodine-131	207-212	thyroglobulin	Homo sapiens	40-53
21105043-3	2011	Negatively correlated with iodine levels, serum thyroglobulin (Tg) is a more sensitive biomarker of iodine deficiency than goiter.	Iodine	27-33	thyroglobulin	Homo sapiens	48-61
22136265-3	2011	Values for serum thyroglobulin (Tg) measurements when serum thyrotropin (TSH) is &gt;30 muU/mL, as a result of either recombinant TSH or L-thyroxine withdrawal, referred to here as stimulated Tg (STg), have been previously evaluated.	Thyroxine	137-148	thyroglobulin	Homo sapiens	17-30
21105043-3	2011	Negatively correlated with iodine levels, serum thyroglobulin (Tg) is a more sensitive biomarker of iodine deficiency than goiter.	Iodine	27-33	thyroglobulin	Homo sapiens	63-65
21105043-3	2011	Negatively correlated with iodine levels, serum thyroglobulin (Tg) is a more sensitive biomarker of iodine deficiency than goiter.	Iodine	100-106	thyroglobulin	Homo sapiens	48-61
21105043-3	2011	Negatively correlated with iodine levels, serum thyroglobulin (Tg) is a more sensitive biomarker of iodine deficiency than goiter.	Iodine	100-106	thyroglobulin	Homo sapiens	63-65
22165686-0	2011	Evaluation of radioiodine therapy in differentiated thyroid cancer subjects with elevated serum thyroglobulin and negative whole body scan using 131I with emphasize on the thallium scintigraphy in these subgroups.	Iodine-131	14-25	thyroglobulin	Homo sapiens	96-109
22332559-8	2011	RESULTS: TgAb led to underestimation of serum Tg values by 15%-50% in 8 patients with DTC.	dtc	86-89	thyroglobulin	Homo sapiens	9-11
22332559-9	2011	TgAb was correlated with the magnitude of underestimated serum Tg values in 3 patients with DTC, but not in the other 5 patients with DTC.	dtc	92-95	thyroglobulin	Homo sapiens	0-2
22332559-10	2011	CONCLUSION: TgAb underestimated serum Tg values in a dose-dependent manner in some patients with DTC, but not in others.	dtc	97-100	thyroglobulin	Homo sapiens	12-14
21816825-4	2011	Transition from partially mature to mature Tg occurs as a discrete "jump" in mobility by nonreducing SDS-PAGE, suggesting formation of at most a few final pairings of Cys residues that may be separated by significant intervening primary sequence.	Sodium Dodecyl Sulfate	101-104	thyroglobulin	Homo sapiens	43-45
21816825-4	2011	Transition from partially mature to mature Tg occurs as a discrete "jump" in mobility by nonreducing SDS-PAGE, suggesting formation of at most a few final pairings of Cys residues that may be separated by significant intervening primary sequence.	Cysteine	167-170	thyroglobulin	Homo sapiens	43-45
21816825-7	2011	Introduction of the Tg-C1245R mutation in the hinge (identical to that causing human goitrous hypothyroidism) inhibits this maturation, although the Cys-1245 partner remains unidentified.	Cysteine	149-152	thyroglobulin	Homo sapiens	20-22
21757724-7	2011	Using chromatin immunoprecipitation, we demonstrated that IRF-1 binds to the 5" TG promoter motif, and the transcription factor binding correlates with active chromatin structure and is marked by enrichment of mono-methylated Lys-4 residue of histone H3, a signature of active transcriptional enhancers.	Lysine	226-229	thyroglobulin	Homo sapiens	80-82
23326066-13	2011	CONCLUSION: Our findings suggest that retinoic acid therapy may induce radioiodine uptake and reduce serum thyroglobulin levels in some patients with DTC, but whether this results in clinically significant response can only be ascertained on long-term follow-up.	Tretinoin	38-51	thyroglobulin	Homo sapiens	107-120
21933495-12	2011	CONCLUSIONS: Although low, a cut-off Tg level of 1.3 ng/ml represents a simple indication for further investigation in patients receiving thyroxine after completion of treatment for thyroid cancer, in the absence of measurement of anti-Tg auto-antibodies.	Thyroxine	138-147	thyroglobulin	Homo sapiens	37-39
21461735-0	2011	Success of the postoperative 131I therapy in young Belarusian patients with differentiated thyroid cancer after Chernobyl depends on the radiation absorbed dose to the blood and the thyroglobulin level.	Iodine-131	29-33	thyroglobulin	Homo sapiens	182-195
23326066-13	2011	CONCLUSION: Our findings suggest that retinoic acid therapy may induce radioiodine uptake and reduce serum thyroglobulin levels in some patients with DTC, but whether this results in clinically significant response can only be ascertained on long-term follow-up.	dtc	150-153	thyroglobulin	Homo sapiens	107-120
21737629-0	2011	Response of thyroglobulin to radioiodine therapy in thyroglobulin-elevated negative iodine scintigraphy (TENIS) syndrome.	Iodine-131	29-40	thyroglobulin	Homo sapiens	12-25
21737629-0	2011	Response of thyroglobulin to radioiodine therapy in thyroglobulin-elevated negative iodine scintigraphy (TENIS) syndrome.	Iodine-131	29-40	thyroglobulin	Homo sapiens	52-65
21737629-0	2011	Response of thyroglobulin to radioiodine therapy in thyroglobulin-elevated negative iodine scintigraphy (TENIS) syndrome.	Iodine	34-40	thyroglobulin	Homo sapiens	12-25
21737629-0	2011	Response of thyroglobulin to radioiodine therapy in thyroglobulin-elevated negative iodine scintigraphy (TENIS) syndrome.	Iodine	34-40	thyroglobulin	Homo sapiens	52-65
21471170-10	2011	CONCLUSION: In patients with DTC, the cross analysis of postablation (131)I scintigraphy with neck and thorax SPECT-CT and stimulated serum Tg level enables early assessment of the risk of persistent or recurrent disease.	dtc	29-32	thyroglobulin	Homo sapiens	140-142
21272685-4	2011	There are no randomized studies to prove that this treatment prolongs life, although there is definite evidence of cell killing, because the serum thyroglobulin level frequently diminishes after radioiodine therapy.	Iodine-131	195-206	thyroglobulin	Homo sapiens	147-160
21378092-4	2011	Thus, physiological concentrations of Tg significantly suppress thyroid-specific gene expression and antagonize the TSH-mediated stimulation that induces expression of thyroid-specific genes.	Thyrotropin	116-119	thyroglobulin	Homo sapiens	38-40
21378092-7	2011	These results indicate that Tg is an essential autocrine regulator of physiological thyroid follicular function that counteracts the effects of TSH.	Thyrotropin	144-147	thyroglobulin	Homo sapiens	28-30
21385076-6	2011	SUMMARY: The acute onset of severe thyroid pain, rapid increase in serum Free Thyroxine Index, and thyroglobulin concentrations with a triiodothyronine to free thyroxine index ratio of &lt; 20 to 1 were compatible with an acute onset destructive thyroiditis, likely related to direct toxicity from the iodinated contrast material.	Triiodothyronine	135-151	thyroglobulin	Homo sapiens	99-112
21385076-6	2011	SUMMARY: The acute onset of severe thyroid pain, rapid increase in serum Free Thyroxine Index, and thyroglobulin concentrations with a triiodothyronine to free thyroxine index ratio of &lt; 20 to 1 were compatible with an acute onset destructive thyroiditis, likely related to direct toxicity from the iodinated contrast material.	Thyroxine	160-169	thyroglobulin	Homo sapiens	99-112
21191314-0	2011	Serum thyroglobulin predicts thyroid remnant ablation failure with 30 mCi iodine-131 treatment in patients with papillary thyroid carcinoma.	Iodine-131	74-84	thyroglobulin	Homo sapiens	6-19
22715205-7	2011	Four months after radioactive iodine therapy, thyroglobulin level is low and the patient remains to have no evidence of disease.	Iodine	30-36	thyroglobulin	Homo sapiens	46-59
21039721-0	2011	The value of detectable thyroglobulin in patients with differentiated thyroid cancer after initial 131I therapy.	Iodine-131	99-103	thyroglobulin	Homo sapiens	24-37
21412391-2	2011	AIM OF THE STUDY: To evaluate the association between moderately elevated stimulated thyroglobulin levels and the persistence of papillary thyroid carcinoma one year after thyroidectomy and radioiodine ablation.	Iodine-131	190-201	thyroglobulin	Homo sapiens	85-98
21349803-3	2011	Within the latter domain, recent interest has been focused on two areas: a) the role of iodinated peptides in thyroglobulin (Tg)--the molecular site of biosynthesis and storage of iodotyrosines and iodothyronines--in triggering an autoimmune cascade, and b) the role of iodine-induced apoptosis/necrosis of thyrocytes in the disease process.	Monoiodotyrosine	180-193	thyroglobulin	Homo sapiens	110-123
21349803-3	2011	Within the latter domain, recent interest has been focused on two areas: a) the role of iodinated peptides in thyroglobulin (Tg)--the molecular site of biosynthesis and storage of iodotyrosines and iodothyronines--in triggering an autoimmune cascade, and b) the role of iodine-induced apoptosis/necrosis of thyrocytes in the disease process.	iodothyronines	198-212	thyroglobulin	Homo sapiens	110-123
21349803-3	2011	Within the latter domain, recent interest has been focused on two areas: a) the role of iodinated peptides in thyroglobulin (Tg)--the molecular site of biosynthesis and storage of iodotyrosines and iodothyronines--in triggering an autoimmune cascade, and b) the role of iodine-induced apoptosis/necrosis of thyrocytes in the disease process.	Iodine	270-276	thyroglobulin	Homo sapiens	110-123
21149483-2	2011	The aim of this study was to evaluate the additional value of DxWBS to stimulated thyroglobulin measurement in high-risk patients.	dxwbs	62-67	thyroglobulin	Homo sapiens	82-95
21422690-3	2011	She was diagnosed with Evans syndrome associated with Graves" disease and treated with propylthiouracil without corticosteroids, which normalized her thyroglobulin level.	Propylthiouracil	87-103	thyroglobulin	Homo sapiens	150-163
21149483-6	2011	Of the patients with detectable thyroglobulin levels, the DxWBS results were negative in 65 and positive in only 8.	dxwbs	58-63	thyroglobulin	Homo sapiens	32-45
21149483-7	2011	The 6 patients positive for thyroglobulin antibody had negative DxWBS results.	dxwbs	64-69	thyroglobulin	Homo sapiens	28-41
21913492-2	2011	The major pathways in thyroid hormone biosynthesis begin with iodine metabolism which occurs in three sequential steps: active iodide transport into thyroid followed by iodide oxidation and subsequent iodination of tyrosyl residues of thyroglobulin (Tg) to produce idotyrosines monoidotyrosine (MIT) and diiodothyrosine (DIT) on Tg.	Iodine	62-68	thyroglobulin	Homo sapiens	235-248
21913492-2	2011	The major pathways in thyroid hormone biosynthesis begin with iodine metabolism which occurs in three sequential steps: active iodide transport into thyroid followed by iodide oxidation and subsequent iodination of tyrosyl residues of thyroglobulin (Tg) to produce idotyrosines monoidotyrosine (MIT) and diiodothyrosine (DIT) on Tg.	cyclo(tyrosyl-tyrosyl)	215-222	thyroglobulin	Homo sapiens	235-248
21913492-2	2011	The major pathways in thyroid hormone biosynthesis begin with iodine metabolism which occurs in three sequential steps: active iodide transport into thyroid followed by iodide oxidation and subsequent iodination of tyrosyl residues of thyroglobulin (Tg) to produce idotyrosines monoidotyrosine (MIT) and diiodothyrosine (DIT) on Tg.	idotyrosines monoidotyrosine	265-293	thyroglobulin	Homo sapiens	235-248
21913492-2	2011	The major pathways in thyroid hormone biosynthesis begin with iodine metabolism which occurs in three sequential steps: active iodide transport into thyroid followed by iodide oxidation and subsequent iodination of tyrosyl residues of thyroglobulin (Tg) to produce idotyrosines monoidotyrosine (MIT) and diiodothyrosine (DIT) on Tg.	2-Methyl-4-isothiazolin-3-one	295-298	thyroglobulin	Homo sapiens	235-248
21913492-2	2011	The major pathways in thyroid hormone biosynthesis begin with iodine metabolism which occurs in three sequential steps: active iodide transport into thyroid followed by iodide oxidation and subsequent iodination of tyrosyl residues of thyroglobulin (Tg) to produce idotyrosines monoidotyrosine (MIT) and diiodothyrosine (DIT) on Tg.	diiodothyrosine	304-319	thyroglobulin	Homo sapiens	235-248
21913492-2	2011	The major pathways in thyroid hormone biosynthesis begin with iodine metabolism which occurs in three sequential steps: active iodide transport into thyroid followed by iodide oxidation and subsequent iodination of tyrosyl residues of thyroglobulin (Tg) to produce idotyrosines monoidotyrosine (MIT) and diiodothyrosine (DIT) on Tg.	3,3'-diindolyl-2,2'-tetrasulfide	321-324	thyroglobulin	Homo sapiens	235-248
24899964-13	2010	The serum Tg level (TSH stimulated) was significantly different among groups A, B, and C (p = 0.0030).	Thyrotropin	20-23	thyroglobulin	Homo sapiens	10-12
21179279-4	2010	The patients were classified according to surveillance DxWBS findings and TSH-stimulated Tg levels 6 to 12 months after the initial RAI.	Thyrotropin	74-77	thyroglobulin	Homo sapiens	89-91
21088504-2	2010	After thyroidectomy and 131I ablation for differentiated thyroid cancer (DTC), serum thyroglobulin (Tg) became a sensitive marker of residual disease.	Iodine-131	24-28	thyroglobulin	Homo sapiens	85-98
21712915-11	2010	Our patient showed false positive (18)F Fluorodeoxyglucose (FDG) uptake in spinal cord at D11/12 and D12/L1 vertebral levels in FDG PET CT imaging performed as part of raised Thyroglobulin workup.	Fluorodeoxyglucose F18	40-58	thyroglobulin	Homo sapiens	175-188
21113746-0	2010	Role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in patients affected by differentiated thyroid carcinoma, high thyroglobulin level, and negative 131I scan: review of the literature.	Fluorodeoxyglucose F18	8-30	thyroglobulin	Homo sapiens	143-156
21712915-11	2010	Our patient showed false positive (18)F Fluorodeoxyglucose (FDG) uptake in spinal cord at D11/12 and D12/L1 vertebral levels in FDG PET CT imaging performed as part of raised Thyroglobulin workup.	Fluorodeoxyglucose F18	60-63	thyroglobulin	Homo sapiens	175-188
20080852-0	2010	Empiric high-dose 131-iodine therapy lacks efficacy for treated papillary thyroid cancer patients with detectable serum thyroglobulin, but negative cervical sonography and 18F-fluorodeoxyglucose positron emission tomography scan.	Iodine-131	18-28	thyroglobulin	Homo sapiens	120-133
20410234-4	2010	OBJECTIVE: To reveal new aspects of thyroglobulin pathophysiology through clinical, cellular, molecular, and genetic studies in a family presenting with CH due to TG mutations from Galicia, an iodine-deficient area of Spain.	Iodine	193-199	thyroglobulin	Homo sapiens	36-49
20410234-4	2010	OBJECTIVE: To reveal new aspects of thyroglobulin pathophysiology through clinical, cellular, molecular, and genetic studies in a family presenting with CH due to TG mutations from Galicia, an iodine-deficient area of Spain.	Iodine	193-199	thyroglobulin	Homo sapiens	163-165
20187016-0	2010	Application of post-surgical stimulated thyroglobulin for radioiodine remnant ablation selection in low-risk papillary thyroid carcinoma.	Iodine-131	58-69	thyroglobulin	Homo sapiens	40-53
20187016-1	2010	BACKGROUND: We present our ongoing experience in the use of postsurgical stimulated serum thyroglobulin (Stim-Tg) to assist in radioiodine remnant ablation (RRA) decision-making.	Iodine-131	127-138	thyroglobulin	Homo sapiens	90-103
21341506-6	2010	Stimulation of the lipopolysaccharide-pretreated thyroid gland with thyroid-stimulating hormone increases resorbtion of thyroglobulin and thyroid hormone production.	Thyrotropin	68-95	thyroglobulin	Homo sapiens	120-133
20561773-9	2010	In studies in which data were available for serum Tg levels during thyroid-stimulating hormone (TSH) suppression therapy or TSH withdrawal, 188 of 337 patients (56%) showed a decrease in serum Tg.	Thyrotropin	67-94	thyroglobulin	Homo sapiens	50-52
20561773-9	2010	In studies in which data were available for serum Tg levels during thyroid-stimulating hormone (TSH) suppression therapy or TSH withdrawal, 188 of 337 patients (56%) showed a decrease in serum Tg.	Thyrotropin	96-99	thyroglobulin	Homo sapiens	50-52
20561773-9	2010	In studies in which data were available for serum Tg levels during thyroid-stimulating hormone (TSH) suppression therapy or TSH withdrawal, 188 of 337 patients (56%) showed a decrease in serum Tg.	Thyrotropin	96-99	thyroglobulin	Homo sapiens	193-195
20561773-9	2010	In studies in which data were available for serum Tg levels during thyroid-stimulating hormone (TSH) suppression therapy or TSH withdrawal, 188 of 337 patients (56%) showed a decrease in serum Tg.	Thyrotropin	124-127	thyroglobulin	Homo sapiens	193-195
20561773-13	2010	However, considering that 44% of patients with DTC with elevated Tg and negative scan results showed spontaneous normalisation and a significant reduction in serum Tg without any specific treatment, (131)I therapy should be individualised according to clinical characteristics.	dtc	47-50	thyroglobulin	Homo sapiens	65-67
20561773-13	2010	However, considering that 44% of patients with DTC with elevated Tg and negative scan results showed spontaneous normalisation and a significant reduction in serum Tg without any specific treatment, (131)I therapy should be individualised according to clinical characteristics.	dtc	47-50	thyroglobulin	Homo sapiens	164-166
20087681-10	2010	We found multiple effects of excess iodine, including changing the immunogenicity of the thyroglobulin molecule and the upregulation of ICAM-1 and ROS in the thyrocyte itself.	Iodine	36-42	thyroglobulin	Homo sapiens	89-102
20399540-2	2010	In this study we investigated the utility for the detection of Tg and TSH-R mRNA by RT-PCR in patients with differentiated thyroid cancer (DTC) during treatment with levothyroxine.	Thyroxine	166-179	thyroglobulin	Homo sapiens	63-65
20399540-8	2010	Lower levels of Tg mRNA in patients with DTC without evidence of disease, although not significant, may indicate that small numbers of thyroid cells may be normally present in the circulation or may represent an ectopic transcription of messengers from blood cells.	dtc	41-44	thyroglobulin	Homo sapiens	16-18
20080852-1	2010	CONTEXT: Some patients with elevated serum thyroglobulin (Tg) but a negative diagnostic whole body scan (WBS) after initial therapy for differentiated thyroid carcinoma may benefit from empirical radioactive iodine (RAI) therapy.	radioactive iodine	196-214	thyroglobulin	Homo sapiens	43-56
20080852-1	2010	CONTEXT: Some patients with elevated serum thyroglobulin (Tg) but a negative diagnostic whole body scan (WBS) after initial therapy for differentiated thyroid carcinoma may benefit from empirical radioactive iodine (RAI) therapy.	radioactive iodine	196-214	thyroglobulin	Homo sapiens	58-60
20080852-1	2010	CONTEXT: Some patients with elevated serum thyroglobulin (Tg) but a negative diagnostic whole body scan (WBS) after initial therapy for differentiated thyroid carcinoma may benefit from empirical radioactive iodine (RAI) therapy.	Insulin, Short-Acting	216-219	thyroglobulin	Homo sapiens	43-56
20080852-1	2010	CONTEXT: Some patients with elevated serum thyroglobulin (Tg) but a negative diagnostic whole body scan (WBS) after initial therapy for differentiated thyroid carcinoma may benefit from empirical radioactive iodine (RAI) therapy.	Insulin, Short-Acting	216-219	thyroglobulin	Homo sapiens	58-60
20063339-0	2010	Photoassisted synthesis of luminescent mannose-Au nanodots for the detection of thyroglobulin in serum.	Mannose	39-46	thyroglobulin	Homo sapiens	80-93
20172468-6	2010	The best indicators for iodine deficiency in children are thyroid-stimulating hormone (TSH) in newborns and thyroglobulin (Tg) in older children.	Iodine	24-30	thyroglobulin	Homo sapiens	108-121
20063339-0	2010	Photoassisted synthesis of luminescent mannose-Au nanodots for the detection of thyroglobulin in serum.	Gold	47-49	thyroglobulin	Homo sapiens	80-93
20063339-1	2010	We have employed mannose-modified gold nanodots (Man-Au NDs) as a luminescence sensor for the detection of the thyroid-cancer marker thyroglobulin (Tg) in homogeneous solutions.	Mannose	17-24	thyroglobulin	Homo sapiens	133-146
19636213-0	2010	Low thyroglobulin concentrations after thyroidectomy increase the prognostic value of undetectable thyroglobulin levels on levo-thyroxine suppressive treatment in low-risk differentiated thyroid cancer.	Thyroxine	123-137	thyroglobulin	Homo sapiens	4-17
19636213-0	2010	Low thyroglobulin concentrations after thyroidectomy increase the prognostic value of undetectable thyroglobulin levels on levo-thyroxine suppressive treatment in low-risk differentiated thyroid cancer.	Thyroxine	123-137	thyroglobulin	Homo sapiens	99-112
19636213-1	2010	DESIGN: Recombinant human TSH-stimulated thyroglobulin (Tg) levels (rhTSH-Tg) are sufficient for early follow-up of low-risk differentiated thyroid cancer (DTC) patients after thyroidectomy and radioiodine (131I) remnant ablation (RAI).	Iodine-131	194-205	thyroglobulin	Homo sapiens	41-54
19636213-1	2010	DESIGN: Recombinant human TSH-stimulated thyroglobulin (Tg) levels (rhTSH-Tg) are sufficient for early follow-up of low-risk differentiated thyroid cancer (DTC) patients after thyroidectomy and radioiodine (131I) remnant ablation (RAI).	Iodine-131	207-211	thyroglobulin	Homo sapiens	41-54
19636213-3	2010	During long-term follow-up, Tg levels on levo-T4 (L-T4) suppressive treatment (suppressive-Tg) is sufficiently sensitive to avoid further evaluations in patients with undetectable rhTSH-Tg.	levo-t4	41-48	thyroglobulin	Homo sapiens	28-30
19636213-3	2010	During long-term follow-up, Tg levels on levo-T4 (L-T4) suppressive treatment (suppressive-Tg) is sufficiently sensitive to avoid further evaluations in patients with undetectable rhTSH-Tg.	levo-t4	41-48	thyroglobulin	Homo sapiens	91-93
19636213-3	2010	During long-term follow-up, Tg levels on levo-T4 (L-T4) suppressive treatment (suppressive-Tg) is sufficiently sensitive to avoid further evaluations in patients with undetectable rhTSH-Tg.	levo-t4	41-48	thyroglobulin	Homo sapiens	91-93
19636213-3	2010	During long-term follow-up, Tg levels on levo-T4 (L-T4) suppressive treatment (suppressive-Tg) is sufficiently sensitive to avoid further evaluations in patients with undetectable rhTSH-Tg.	Thyroxine	50-54	thyroglobulin	Homo sapiens	28-30
19636213-3	2010	During long-term follow-up, Tg levels on levo-T4 (L-T4) suppressive treatment (suppressive-Tg) is sufficiently sensitive to avoid further evaluations in patients with undetectable rhTSH-Tg.	Thyroxine	50-54	thyroglobulin	Homo sapiens	91-93
19636213-3	2010	During long-term follow-up, Tg levels on levo-T4 (L-T4) suppressive treatment (suppressive-Tg) is sufficiently sensitive to avoid further evaluations in patients with undetectable rhTSH-Tg.	Thyroxine	50-54	thyroglobulin	Homo sapiens	91-93
20353278-9	2010	According to the results of this prospective study, venous sampling for Tg may be a useful tool to localize recurrent or perhaps persistent DTC in the neck for patients who have no detectable disease on radioiodine scans or other imaging studies.	dtc	140-143	thyroglobulin	Homo sapiens	72-74
20026964-9	2010	CONCLUSION: These results indicate that the residual LN metastasis was relatively common in high-risk PTC patients receiving adjuvant I-131 therapy whose serum Tg levels remained detectable, and those lesions often had no I-131 accumulation.	Iodine-131	134-139	thyroglobulin	Homo sapiens	160-162
20953412-11	2010	Mean postoperative serum thyroglobulin level off levothyroxine was 5.4 ng/mL.	Thyroxine	49-62	thyroglobulin	Homo sapiens	25-38
20353278-9	2010	According to the results of this prospective study, venous sampling for Tg may be a useful tool to localize recurrent or perhaps persistent DTC in the neck for patients who have no detectable disease on radioiodine scans or other imaging studies.	Iodine-131	203-214	thyroglobulin	Homo sapiens	72-74
19633549-4	2009	Some mutated thyroglobulin may escape the rigorous chaperone control and reach the colloid, allowing a wide phenotypic spectrum that includes euthyroidism in an adequate iodine environment.	Iodine	170-176	thyroglobulin	Homo sapiens	13-26
20017617-2	2010	The interest in using recombinant human TSH (rhTSH) stimulation of fluoro-2-deoxy-D-glucose (FDG) with positron emission tomography (PET) has been shown, but mainly for patients with high serum thyroglobulin (Tg) concentration.	fluoro-2-deoxy-d-glucose	67-91	thyroglobulin	Homo sapiens	194-207
20001720-4	2009	SUMMARY: The benefits of I-131 remnant ablation include: [1] facilitating the interpretation of subsequent serum thyroglobulin levels, [2] increasing the sensitivity of detection of locoregional and/or metastatic disease on subsequent follow-up radioactive iodine whole-body scans, [3] maximizing the therapeutic effect of subsequent treatments, and [4] allowing a postablation scan to help identify additional sites of disease that were not identified on the preablation scan or when a preablation scan was not performed.	Iodine-131	25-30	thyroglobulin	Homo sapiens	113-126
19678746-0	2009	Results of rosiglitazone therapy in patients with thyroglobulin-positive and radioiodine-negative advanced differentiated thyroid cancer.	Rosiglitazone	11-24	thyroglobulin	Homo sapiens	50-63
20201435-1	2009	We have demonstrated a time-resolved luminescence (TRL) assay for the sensitive and selective detection of thyroglobulin (Tg), a thyroid cancer marker, in homogeneous solution using water-soluble alpha-D-mannose-conjugated Au nanodots (Man-Au NDs).	Water	182-187	thyroglobulin	Homo sapiens	107-120
20201435-1	2009	We have demonstrated a time-resolved luminescence (TRL) assay for the sensitive and selective detection of thyroglobulin (Tg), a thyroid cancer marker, in homogeneous solution using water-soluble alpha-D-mannose-conjugated Au nanodots (Man-Au NDs).	alpha-D-Mannose	196-211	thyroglobulin	Homo sapiens	107-120
20201435-1	2009	We have demonstrated a time-resolved luminescence (TRL) assay for the sensitive and selective detection of thyroglobulin (Tg), a thyroid cancer marker, in homogeneous solution using water-soluble alpha-D-mannose-conjugated Au nanodots (Man-Au NDs).	Gold	223-225	thyroglobulin	Homo sapiens	107-120
19772638-5	2009	RESULTS: The proteolytic potencies of cysteine cathepsins B, K, L and S towards thyroglobulin were analyzed under conditions simulating oxidizing versus reducing environments with neutral to acidic pH values.	Cysteine	38-46	thyroglobulin	Homo sapiens	80-93
19772638-9	2009	All analyzed cathepsins generated distinct fragments of thyroglobulin at extracellular versus endo-lysosomal conditions as demonstrated by SDS-PAGE followed by immunoblotting or N-terminal sequencing.	Sodium Dodecyl Sulfate	139-142	thyroglobulin	Homo sapiens	56-69
19772638-11	2009	CONCLUSION: The results revealed distinct cleavage patterns at all conditions analyzed, indicating compartment-specific processing of thyroglobulin by cysteine cathepsins.	Cysteine	151-159	thyroglobulin	Homo sapiens	134-147
19556382-0	2009	Thyroglobulin as a marker of iodine nutrition status in the general population.	Iodine	29-35	thyroglobulin	Homo sapiens	0-13
19556382-2	2009	In this prospective study of a mandatory iodization programme, we aimed to evaluate serum thyroglobulin (Tg) as a marker of iodine status in the population.	Iodine	124-130	thyroglobulin	Homo sapiens	90-103
19556382-2	2009	In this prospective study of a mandatory iodization programme, we aimed to evaluate serum thyroglobulin (Tg) as a marker of iodine status in the population.	Iodine	124-130	thyroglobulin	Homo sapiens	105-107
19556382-11	2009	CONCLUSION: We found serum Tg to be a suitable marker of iodine nutrition status in the population.	Iodine	57-63	thyroglobulin	Homo sapiens	27-29
19678746-6	2009	Unstimulated thyroglobulin levels after rosiglitazone treatment increased in five patients, remained stable in 12 patients, and decreased in three patients.	Rosiglitazone	40-53	thyroglobulin	Homo sapiens	13-26
19678746-11	2009	CONCLUSIONS: Our findings suggest that rosiglitazone therapy may induce radioiodine uptake and reduce serum thyroglobulin levels in some patients with differentiated thyroid cancer but this did not result in clinically significant response on long-term follow-up.	Rosiglitazone	39-52	thyroglobulin	Homo sapiens	108-121
18854619-7	2009	Six out of 11 patients showed significantly increased (above 50%) Tg levels just after RA therapy.	Radium	87-89	thyroglobulin	Homo sapiens	66-68
19415387-1	2009	BACKGROUND: Objectives were to analyze the relationship between a positive (18)F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) result and clinical and tumor factors in patients treated for differentiated thyroid cancer (DTC) and under suspicion of recurrence or metastasis, and to determine the diagnostic validity of PET in DTC patients with elevated serum thyroglobulin (Tg) and negative (131)I whole-body scan ((131)I-WBS).	Fluorodeoxyglucose F18	101-104	thyroglobulin	Homo sapiens	372-385
19415387-1	2009	BACKGROUND: Objectives were to analyze the relationship between a positive (18)F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) result and clinical and tumor factors in patients treated for differentiated thyroid cancer (DTC) and under suspicion of recurrence or metastasis, and to determine the diagnostic validity of PET in DTC patients with elevated serum thyroglobulin (Tg) and negative (131)I whole-body scan ((131)I-WBS).	Fluorodeoxyglucose F18	101-104	thyroglobulin	Homo sapiens	387-389
19415387-2	2009	METHODS: We studied 50 DTC patients with elevated serum Tg and negative WBS treated with total thyroidectomy and (131)I ablation.	dtc	23-26	thyroglobulin	Homo sapiens	56-58
18207685-8	2009	CONCLUSION: F-18 FDG PET/CT is suitable for the detection and precise localization of loco-regional recurrences and distant metastases of DTC in patients with elevated serum Tg but negative I-123 whole body scan.	dtc	138-141	thyroglobulin	Homo sapiens	174-176
19383064-1	2009	BACKGROUND: Recombinant human thyroid-stimulating hormone (Thyrogen; Genzyme Corporation, Cambridge, MA, USA) (rhTSH)-stimulated serum thyroglobulin (Tg) (stim-Tg) and (131)I whole-body scanning (WBS) have been reported to allow follow up of patients with thyroid cancer without the symptoms of thyroxine withdrawal and with equivalent diagnostic information to that obtained after thyroxine withdrawal.	Thyroxine	295-304	thyroglobulin	Homo sapiens	135-148
19383064-1	2009	BACKGROUND: Recombinant human thyroid-stimulating hormone (Thyrogen; Genzyme Corporation, Cambridge, MA, USA) (rhTSH)-stimulated serum thyroglobulin (Tg) (stim-Tg) and (131)I whole-body scanning (WBS) have been reported to allow follow up of patients with thyroid cancer without the symptoms of thyroxine withdrawal and with equivalent diagnostic information to that obtained after thyroxine withdrawal.	Thyroxine	382-391	thyroglobulin	Homo sapiens	135-148
19589101-8	2009	A negative interference is a more challenging problem because increases in Tg generally occur as the first sign of recurrence of DTC.	dtc	129-132	thyroglobulin	Homo sapiens	75-77
19589101-9	2009	Therefore, treatment using HBT tubes of all sera referred for Tg measurement should be considered in order to prevent both unwarranted investigations or therapy, and delayed diagnosis of recurrence in patients affected by DTC.	hbt	27-30	thyroglobulin	Homo sapiens	62-64
19589104-5	2009	Six months after thyroid ablation (i.e., thyroidectomy plus radioiodine) serum Tg was measured during TSH-suppressive thyroxine (T4) treatment (onT4-Tg).	Iodine-131	60-71	thyroglobulin	Homo sapiens	79-81
19589104-5	2009	Six months after thyroid ablation (i.e., thyroidectomy plus radioiodine) serum Tg was measured during TSH-suppressive thyroxine (T4) treatment (onT4-Tg).	Thyrotropin	102-105	thyroglobulin	Homo sapiens	79-81
19589104-14	2009	When onT4-Tg became detectable during follow-up, the evaluation of Tg slope in a 3-6 months period accurately discriminated patients with DTC recurrence from those without recurrence.	dtc	138-141	thyroglobulin	Homo sapiens	10-12
19509106-13	2009	In the presence of sufficient iodine supply, some patients with TG mutations are able to compensate the impaired hormonogenesis and generate thyroid hormone.	Iodine	30-36	thyroglobulin	Homo sapiens	64-66
19265500-2	2009	The aim of this study was to clarify these conflicting results by examining if prolonged high iodide exposition with or without interferon (IFN)-gamma has an effect on human primary thyroid cell proliferation, thyroglobulin (Tg) production, and intercellular adhesion molecule-1 (ICAM-1) and human leukocyte antigen (HLA)-DR expression.	Iodides	94-100	thyroglobulin	Homo sapiens	210-223
19033781-8	2008	CONCLUSION: Total body imaging with I-123 was more sensitive than I-131 TBI scanning for detecting residual or recurrent disease in patients with well-differentiated thyroid cancer presenting with low preoperative thyroglobulin levels.	Iodine-123	36-41	thyroglobulin	Homo sapiens	214-227
19033784-11	2008	After therapy, serum Tg levels decreased significantly in the group that initially showed accumulation of I-131 in DWS (P = 0.045).	Iodine-131	106-111	thyroglobulin	Homo sapiens	21-23
18363882-4	2008	The present study was undertaken to evaluate if post-thyroidectomy Tg values, measured before rhTSH-stimulated radioiodine ablation is of prognostic value in patients affected by DTC.	dtc	179-182	thyroglobulin	Homo sapiens	67-69
18801935-9	2008	CONCLUSIONS: Immunoaffinity peptide enrichment-tandem mass spectrometry can detect tryptic peptides of thyroglobulin at picomolar concentrations while also digesting the endogenous immunoglobulins that can potentially interfere with traditional immunoassays.	Peptides	91-99	thyroglobulin	Homo sapiens	103-116
19169488-5	2008	Anti-TG antibodies progressively decreased after surgery for metastatic lymph nodes resection followed by radioiodine therapy.	Iodine-131	106-117	thyroglobulin	Homo sapiens	5-7
18596923-1	2008	Thyroid hormonogenesis requires secretion of thyroglobulin, a protein comprising Cys-rich regions I, II, and III (referred to collectively as region I-II-III) followed by a cholinesterase-like (ChEL) domain.	Cysteine	81-84	thyroglobulin	Homo sapiens	45-58
18788923-5	2008	Before she was lost to followup the serum thyroglobulin (Tg) after recombinant TSH administration was 84 ng/ml (normal values &lt; 2 ng/ml) and there was no uptake on a radioiodine whole body scan.	Thyrotropin	79-82	thyroglobulin	Homo sapiens	42-55
18788923-5	2008	Before she was lost to followup the serum thyroglobulin (Tg) after recombinant TSH administration was 84 ng/ml (normal values &lt; 2 ng/ml) and there was no uptake on a radioiodine whole body scan.	Thyrotropin	79-82	thyroglobulin	Homo sapiens	57-59
19030653-2	2008	The measurement of serum thyroglobulin (sTg) under thyroid hormone suppression therapy the presence of serum thyroglobulin antibodies (sAbTg), the diagnostic whole body scan and cytology can give false negative results.	sabtg	135-140	thyroglobulin	Homo sapiens	25-38
18498765-4	2008	METHODS: We compared 6 different Tg immunometric assays in 53 treated DTC patients in whom serum Tg during TSH-suppression therapy was below an earlier established clinical decision limit of 3 pmol/l (2 ng/ml) by our routine Tg assay, which was one of these 6.	Thyrotropin	107-110	thyroglobulin	Homo sapiens	97-99
18498765-4	2008	METHODS: We compared 6 different Tg immunometric assays in 53 treated DTC patients in whom serum Tg during TSH-suppression therapy was below an earlier established clinical decision limit of 3 pmol/l (2 ng/ml) by our routine Tg assay, which was one of these 6.	Thyrotropin	107-110	thyroglobulin	Homo sapiens	97-99
18630997-0	2008	Rosiglitazone effect on radioiodine uptake in thyroid carcinoma patients with high thyroglobulin but negative total body scan: a correlation with the expression of peroxisome proliferator-activated receptor-gamma.	Rosiglitazone	0-13	thyroglobulin	Homo sapiens	83-96
18607401-3	2008	Long-term iodine exposure leads to increased iodination of thyroglobulin, which increases its antigenicity and initiates the autoimmune process in genetically susceptible individuals.	Iodine	10-16	thyroglobulin	Homo sapiens	59-72
18528186-1	2008	AIM: In differentiated thyroid carcinoma, persistent plasma thyroglobulin (Tg) is a specific marker for persistent or recurrent disease after thyroidectomy and radioiodine ablation.	Iodine-131	160-171	thyroglobulin	Homo sapiens	60-73
18528186-1	2008	AIM: In differentiated thyroid carcinoma, persistent plasma thyroglobulin (Tg) is a specific marker for persistent or recurrent disease after thyroidectomy and radioiodine ablation.	Iodine-131	160-171	thyroglobulin	Homo sapiens	75-77
18630997-0	2008	Rosiglitazone effect on radioiodine uptake in thyroid carcinoma patients with high thyroglobulin but negative total body scan: a correlation with the expression of peroxisome proliferator-activated receptor-gamma.	Iodine-131	24-35	thyroglobulin	Homo sapiens	83-96
18630997-1	2008	BACKGROUND: Thyroid carcinoma patients with high thyroglobulin (Tg) level but negative total body scan (TBS) are difficult to treat with radioiodine (RAI).	Iodine-131	137-148	thyroglobulin	Homo sapiens	49-62
18060877-1	2008	Thyroglobulin (Tg) is a large molecule containing 2750 amino acids with a molecular weight of 330 kD and twenty putative N-linked glycosylation sites.	Nitrogen	121-122	thyroglobulin	Homo sapiens	0-13
18630997-1	2008	BACKGROUND: Thyroid carcinoma patients with high thyroglobulin (Tg) level but negative total body scan (TBS) are difficult to treat with radioiodine (RAI).	Iodine-131	150-153	thyroglobulin	Homo sapiens	49-62
18631006-1	2008	A key issue in the mechanism of thyroglobulin (Tg) iodination by thyroperoxidase (TPO) is whether a TPO-bound iodine intermediate directly iodinates Tg-incorporated tyrosines (specific iodination) or whether reactive iodine species released from TPO effectuate Tg iodination (nonspecific iodination).	Iodine	110-116	thyroglobulin	Homo sapiens	32-45
18631006-1	2008	A key issue in the mechanism of thyroglobulin (Tg) iodination by thyroperoxidase (TPO) is whether a TPO-bound iodine intermediate directly iodinates Tg-incorporated tyrosines (specific iodination) or whether reactive iodine species released from TPO effectuate Tg iodination (nonspecific iodination).	Iodine	110-116	thyroglobulin	Homo sapiens	47-49
18631006-1	2008	A key issue in the mechanism of thyroglobulin (Tg) iodination by thyroperoxidase (TPO) is whether a TPO-bound iodine intermediate directly iodinates Tg-incorporated tyrosines (specific iodination) or whether reactive iodine species released from TPO effectuate Tg iodination (nonspecific iodination).	Iodine	110-116	thyroglobulin	Homo sapiens	149-151
18631006-1	2008	A key issue in the mechanism of thyroglobulin (Tg) iodination by thyroperoxidase (TPO) is whether a TPO-bound iodine intermediate directly iodinates Tg-incorporated tyrosines (specific iodination) or whether reactive iodine species released from TPO effectuate Tg iodination (nonspecific iodination).	Iodine	110-116	thyroglobulin	Homo sapiens	149-151
18631006-1	2008	A key issue in the mechanism of thyroglobulin (Tg) iodination by thyroperoxidase (TPO) is whether a TPO-bound iodine intermediate directly iodinates Tg-incorporated tyrosines (specific iodination) or whether reactive iodine species released from TPO effectuate Tg iodination (nonspecific iodination).	Tyrosine	165-174	thyroglobulin	Homo sapiens	32-45
18631006-1	2008	A key issue in the mechanism of thyroglobulin (Tg) iodination by thyroperoxidase (TPO) is whether a TPO-bound iodine intermediate directly iodinates Tg-incorporated tyrosines (specific iodination) or whether reactive iodine species released from TPO effectuate Tg iodination (nonspecific iodination).	Tyrosine	165-174	thyroglobulin	Homo sapiens	47-49
18631006-1	2008	A key issue in the mechanism of thyroglobulin (Tg) iodination by thyroperoxidase (TPO) is whether a TPO-bound iodine intermediate directly iodinates Tg-incorporated tyrosines (specific iodination) or whether reactive iodine species released from TPO effectuate Tg iodination (nonspecific iodination).	Tyrosine	165-174	thyroglobulin	Homo sapiens	149-151
18631006-1	2008	A key issue in the mechanism of thyroglobulin (Tg) iodination by thyroperoxidase (TPO) is whether a TPO-bound iodine intermediate directly iodinates Tg-incorporated tyrosines (specific iodination) or whether reactive iodine species released from TPO effectuate Tg iodination (nonspecific iodination).	Tyrosine	165-174	thyroglobulin	Homo sapiens	149-151
18631006-1	2008	A key issue in the mechanism of thyroglobulin (Tg) iodination by thyroperoxidase (TPO) is whether a TPO-bound iodine intermediate directly iodinates Tg-incorporated tyrosines (specific iodination) or whether reactive iodine species released from TPO effectuate Tg iodination (nonspecific iodination).	Iodine	217-223	thyroglobulin	Homo sapiens	32-45
18631006-1	2008	A key issue in the mechanism of thyroglobulin (Tg) iodination by thyroperoxidase (TPO) is whether a TPO-bound iodine intermediate directly iodinates Tg-incorporated tyrosines (specific iodination) or whether reactive iodine species released from TPO effectuate Tg iodination (nonspecific iodination).	Iodine	217-223	thyroglobulin	Homo sapiens	47-49
18631006-7	2008	Furthermore, knowledge of TPO structure, gained from X-ray crystallographic studies indicates that access of Tg-bound tyrosyl groups to the active site of TPO is not possible.	cyclo(tyrosyl-tyrosyl)	118-125	thyroglobulin	Homo sapiens	109-111
18465687-10	2008	CONCLUSIONS: Early treatment results of well differentiated thyroid cancer depend on the clinical stage, and postoperative serum thyroglobulin level measured after endogenous TSH stimulation.	Thyrotropin	175-178	thyroglobulin	Homo sapiens	129-142
17538522-0	2008	Fluorodeoxyglucose PET/CT in patients with differentiated thyroid cancer and elevated thyroglobulin after total thyroidectomy and (131)I ablation.	Fluorodeoxyglucose F18	0-18	thyroglobulin	Homo sapiens	86-99
17538522-1	2008	AIM: The aim of this study was to evaluate the role of 18F fluorodeoxyglucose-positron emission tomography (FDG-PET), differentiated thyroid carcinoma (DTC) treated with therapeutic (131)I because of elevated thyroglobulin (Tg) levels during follow up.	Fluorodeoxyglucose F18	59-77	thyroglobulin	Homo sapiens	209-222
18631008-1	2008	BACKGROUND: Thyroglobulin (Tg) is a large glycoprotein that is intimately involved in the biosynthesis of thyroxine and triiodothyronine.	Thyroxine	106-115	thyroglobulin	Homo sapiens	12-25
18631008-1	2008	BACKGROUND: Thyroglobulin (Tg) is a large glycoprotein that is intimately involved in the biosynthesis of thyroxine and triiodothyronine.	Thyroxine	106-115	thyroglobulin	Homo sapiens	27-29
18631008-1	2008	BACKGROUND: Thyroglobulin (Tg) is a large glycoprotein that is intimately involved in the biosynthesis of thyroxine and triiodothyronine.	Triiodothyronine	120-136	thyroglobulin	Homo sapiens	12-25
18631008-1	2008	BACKGROUND: Thyroglobulin (Tg) is a large glycoprotein that is intimately involved in the biosynthesis of thyroxine and triiodothyronine.	Triiodothyronine	120-136	thyroglobulin	Homo sapiens	27-29
18098308-6	2008	CONCLUSIONS: Stimulated thyroglobulin measurements prior to initial radioactive iodine treatment independently predict future stimulated thyroglobulin positivity in well-differentiated thyroid carcinoma.	radioactive iodine	68-86	thyroglobulin	Homo sapiens	137-150
18243140-5	2008	Furthermore, in cultured lymphocytes we compared changes in Tg mRNA expression following stimulation with TSH.	Thyrotropin	106-109	thyroglobulin	Homo sapiens	60-62
18243140-10	2008	The levels of Tg mRNA in the TSH-stimulated lymphocytes were noticeably increased in subjects with thyroid disease.	Thyrotropin	29-32	thyroglobulin	Homo sapiens	14-16
30764086-4	2008	The thyroid cells are the only source of Tg in the human body, therefore, the presence of Tg after total thyroidectomy and ablative 131I therapy indicates persistence or recurrence of DTC.	dtc	184-187	thyroglobulin	Homo sapiens	90-92
30764086-6	2008	Clinically, measurements of thyroid-stimulating hormone (TSH)-stimulated Tg after thyroid hormone withdrawal, or exogenous TSH administration in patients with undetectable serum Tg during thyroid hormone-suppression therapy, is recommended for revealing occult disease.	Thyrotropin	57-60	thyroglobulin	Homo sapiens	73-75
30764086-7	2008	Technically, the development of Tg assays with improved functional sensitivity enhances the value of Tg measurements, allowing us to measure Tg without any TSH stimulation during DTC with high negative predictive value.	Thyrotropin	156-159	thyroglobulin	Homo sapiens	32-34
18060877-1	2008	Thyroglobulin (Tg) is a large molecule containing 2750 amino acids with a molecular weight of 330 kD and twenty putative N-linked glycosylation sites.	Nitrogen	121-122	thyroglobulin	Homo sapiens	15-17
18060877-3	2008	Iodinated Tg is stored in the lumen of the thyroid follicles and is released in response to specific hormonal stimulation by thyroid stimulating hormone (TSH).	Thyrotropin	125-152	thyroglobulin	Homo sapiens	10-12
18060877-3	2008	Iodinated Tg is stored in the lumen of the thyroid follicles and is released in response to specific hormonal stimulation by thyroid stimulating hormone (TSH).	Thyrotropin	154-157	thyroglobulin	Homo sapiens	10-12
17952385-8	2008	Serum thyrotropin/thyroglobulin ratio might be a better index of evaluating iodine status.	Iodine	76-82	thyroglobulin	Homo sapiens	18-31
18042646-1	2008	CONTEXT: Dual oxidase 2 (DUOX2) is the catalytic core of the H(2)O(2) generator crucial for the iodination of thyroglobulin in thyroid hormone synthesis.	Water	61-66	thyroglobulin	Homo sapiens	110-123
18605946-6	2008	As a consequence, undetectable thyroglobulin during thyroxine treatment is sufficient evidence to forgo thyrotropin stimulation in many cases, if a highly sensitive assay is employed.	Thyroxine	52-61	thyroglobulin	Homo sapiens	31-44
18020914-7	2007	MAIN OUTCOMES: Amiodarone at 1-2 muM decreased the expression level of the sodium-iodide symporter (NIS) to nearly half, but did not affect genes participating in thyroid hormonogenesis (thyroid peroxidase, thyroglobulin, pendrin, and NADPH oxidase).	Amiodarone	15-25	thyroglobulin	Homo sapiens	207-220
17473819-8	2007	CONCLUSION: Technetium-99m-MIBI scan improves sensitivity of Tg measurement in patients with suspected metastases from DTC during the course of opotherapy and is a useful alternative to fluorodeoxyglucose-PET or other imaging techniques in patients with elevated serum Tg and negative (131)I-WBS.	technetium-99m-mibi	12-31	thyroglobulin	Homo sapiens	61-63
17473819-8	2007	CONCLUSION: Technetium-99m-MIBI scan improves sensitivity of Tg measurement in patients with suspected metastases from DTC during the course of opotherapy and is a useful alternative to fluorodeoxyglucose-PET or other imaging techniques in patients with elevated serum Tg and negative (131)I-WBS.	technetium-99m-mibi	12-31	thyroglobulin	Homo sapiens	269-271
18063080-9	2007	Mean postoperative serum thyroglobulin level after levothyroxine withdrawal was 5.5 ng/mL.	Thyroxine	51-64	thyroglobulin	Homo sapiens	25-38
18656705-3	2008	We examined the genomic region (11.5cM) containing the Tg gene by genotyping seven microsatellite markers and four SNPs located respectively at exon 10 (Ser715Ala), exon 12 (Met1009Val), exon 21 (Ala1483Ala) and exon 33 (Arg1980Trp) in 15 Tunisian multiplex families affected with AITD including Graves" disease (GD) and Hashimoto"s thyroiditis (HT) (members: 87; patients: 27 GD and 16 HT).	ala1483ala	196-206	thyroglobulin	Homo sapiens	55-57
17900225-0	2007	Recognition of thyroglobulin by T cells: the role of iodine.	Iodine	53-59	thyroglobulin	Homo sapiens	15-28
17561976-1	2007	BACKGROUND: In recent years serum thyroglobulin (Tg) measurement during thyroxine (T4) treatment and/or after stimulation by endogenous TSH or recombinant human TSH (rhTSH) has eclipsed other diagnostic procedures in managing patients with differentiated thyroid cancer (DTC).	Thyroxine	72-81	thyroglobulin	Homo sapiens	34-47
17561976-1	2007	BACKGROUND: In recent years serum thyroglobulin (Tg) measurement during thyroxine (T4) treatment and/or after stimulation by endogenous TSH or recombinant human TSH (rhTSH) has eclipsed other diagnostic procedures in managing patients with differentiated thyroid cancer (DTC).	Thyroxine	72-81	thyroglobulin	Homo sapiens	49-51
17561976-1	2007	BACKGROUND: In recent years serum thyroglobulin (Tg) measurement during thyroxine (T4) treatment and/or after stimulation by endogenous TSH or recombinant human TSH (rhTSH) has eclipsed other diagnostic procedures in managing patients with differentiated thyroid cancer (DTC).	Thyrotropin	136-139	thyroglobulin	Homo sapiens	34-47
17561976-1	2007	BACKGROUND: In recent years serum thyroglobulin (Tg) measurement during thyroxine (T4) treatment and/or after stimulation by endogenous TSH or recombinant human TSH (rhTSH) has eclipsed other diagnostic procedures in managing patients with differentiated thyroid cancer (DTC).	Thyrotropin	161-164	thyroglobulin	Homo sapiens	34-47
17561976-1	2007	BACKGROUND: In recent years serum thyroglobulin (Tg) measurement during thyroxine (T4) treatment and/or after stimulation by endogenous TSH or recombinant human TSH (rhTSH) has eclipsed other diagnostic procedures in managing patients with differentiated thyroid cancer (DTC).	Thyrotropin	161-164	thyroglobulin	Homo sapiens	49-51
17561976-2	2007	However, preoperative undetectable Tg was reported in up to 12% of patients affected by DTC and recurrences of DTC with no increase in serum Tg have also been described.	dtc	88-91	thyroglobulin	Homo sapiens	35-37
17561976-4	2007	AIM: We retrospectively evaluated the incidence of undetectable or reduced preoperative serum Tg in a group of 436 patients affected by DTC.	dtc	136-139	thyroglobulin	Homo sapiens	94-96
17561976-12	2007	CONCLUSIONS: Regardless of the method employed, 3.0-5.1% of patients with DTC showed undetectable or reduced preoperative Tg.	dtc	74-77	thyroglobulin	Homo sapiens	122-124
17900225-1	2007	Among known autoantigens, thyroglobulin (Tg) is unique in its capacity to store iodine, an element provided in our daily diet.	Iodine	80-86	thyroglobulin	Homo sapiens	26-39
17900225-1	2007	Among known autoantigens, thyroglobulin (Tg) is unique in its capacity to store iodine, an element provided in our daily diet.	Iodine	80-86	thyroglobulin	Homo sapiens	41-43
17900225-2	2007	Evolutionary pressure has sculpted Tg into a large molecular scaffolding to allow organification of iodide and its incorporation into thyroid hormones.	Iodides	100-106	thyroglobulin	Homo sapiens	35-37
17555505-9	2007	CONCLUSIONS: The use of a highly sensitive Tg assay may represent a useful diagnostic tool for improving the interpretation of Tg results during monitoring of DTC-treated patients for the early detection of recurrence and for optimizing the use of the more expensive rh-TSH test.	dtc	159-162	thyroglobulin	Homo sapiens	43-45
17532758-1	2007	CONTEXT: Thyroid dyshormonogenesis is associated with mutations in the thyroglobulin (TG) gene and characterized by normal organification of iodide and low serum TG.	Iodides	141-147	thyroglobulin	Homo sapiens	71-84
17532758-1	2007	CONTEXT: Thyroid dyshormonogenesis is associated with mutations in the thyroglobulin (TG) gene and characterized by normal organification of iodide and low serum TG.	Iodides	141-147	thyroglobulin	Homo sapiens	86-88
17426102-2	2007	AIM: The goal of the study is to compare the diagnostic values of seven methods for serum Tg measurement for detecting recurrent disease both during L-T4 treatment and after TSH stimulation.	Thyroxine	149-153	thyroglobulin	Homo sapiens	90-92
17910834-9	2007	CONCLUSIONS: 18F-FDG PET is a useful for detecting residual or recurrent DTC in patients with elevated Tg and negative 131I WBS.	dtc	73-76	thyroglobulin	Homo sapiens	103-105
17891252-0	2007	[Will the thyroglobulin assay with lower functional sensitivity whilst the patients are on L-T4 treatment replace the TSH-stimulated thyroglobulin assay in the follow-up of patients with differentiated thyroid cancer?].	Thyrotropin	118-121	thyroglobulin	Homo sapiens	133-146
17891252-1	2007	The author reviews the literature on the new assays for serum thyroglobulin (sTg) presenting lower functional sensitivity and demonstrates that its use, whilst the patients are taking L-T4, presents better results than sTg following TSH stimulation in the follow-up of patients with differentiated thyroid carcinoma.	Thyroxine	184-188	thyroglobulin	Homo sapiens	62-75
17891252-1	2007	The author reviews the literature on the new assays for serum thyroglobulin (sTg) presenting lower functional sensitivity and demonstrates that its use, whilst the patients are taking L-T4, presents better results than sTg following TSH stimulation in the follow-up of patients with differentiated thyroid carcinoma.	estriol 3-glucuronide	77-80	thyroglobulin	Homo sapiens	62-75
17376195-0	2007	Variable influences of iodine on the T-cell recognition of a single thyroglobulin epitope.	Iodine	23-29	thyroglobulin	Homo sapiens	68-81
17376195-1	2007	We have previously shown that iodotyrosyl formation within certain innocuous thyroglobulin (Tg) peptides confers on them immunopathogenic properties.	iodotyrosyl	30-41	thyroglobulin	Homo sapiens	77-90
17914113-8	2007	We observed a massive increase of thyroglobulin (Tg) concentrations in cases of DTC that started 36-48 h after SETA and did not occur in cases of ATC.	dtc	80-83	thyroglobulin	Homo sapiens	34-47
17956157-8	2007	Controlled trials of iodine supplementation in mildly iodine-deficient pregnant women suggest beneficial effects on maternal and newborn serum thyroglobulin and thyroid volume, but no effects on maternal and newborn total or free thyroid hormone concentrations.	Iodine	21-27	thyroglobulin	Homo sapiens	143-156
17426102-2	2007	AIM: The goal of the study is to compare the diagnostic values of seven methods for serum Tg measurement for detecting recurrent disease both during L-T4 treatment and after TSH stimulation.	Thyrotropin	174-177	thyroglobulin	Homo sapiens	90-92
17426102-11	2007	CONCLUSION: Using an assay with a lower functional sensitivity may give an earlier indication of the presence of Tg in the serum on L-T4 treatment and may be used to study the trend in serum Tg without performing any TSH stimulation.	Thyroxine	132-136	thyroglobulin	Homo sapiens	113-115
17684619-0	2007	[Diagnostic value of positron emission tomography/computed tomography with fluorine-18 fluordeoxyglucose in patients with differentiated thyroid gland carcinoma, high thyroglobulin serum levels and negative iodine whole body scan].	fluorine-18 fluordeoxyglucose	75-104	thyroglobulin	Homo sapiens	167-180
17256140-9	2007	Twenty-nine patients with a negative diagnostic scan were treated with 131I owing to a high serum thyroglobulin level (range 11.3-480 ng/ml).	Iodine-131	71-75	thyroglobulin	Homo sapiens	98-111
17848834-1	2007	We investigated the effect of therapeutic doses of radioiodine (RAI) on peripheral serum messenger thyroglobulin RNA (Tg mRNA) and serum thyroglobulin (sTg) in patients with multinodular goiter (MNG) preceded or not by treatment with recombinant human TSH (rhTSH).	Iodine-131	51-62	thyroglobulin	Homo sapiens	99-112
17560521-3	2007	Recent studies evaluating (18)F-2-fluoro-2-deoxy-D-glucose-positron-emission-tomography, with or without simultaneous computed tomography imaging, are encouraging for its potential utility in thyroid cancer in patients who have an elevated serum thyroglobulin level and a negative (131)I scan.	Fluorodeoxyglucose F18	32-58	thyroglobulin	Homo sapiens	246-259
17679169-5	2007	5-Aza increased TSH-R mRNA expression in both of the cell lines and decreased TPO, NIS, and Tg mRNA levels in the cancer cell line.	5-aza	0-5	thyroglobulin	Homo sapiens	92-94
17679169-7	2007	TSA treatment repressed NIS and Tg mRNA levels and made no change on other thyroid-specific genes that were investigated in the cancer cell line.	trichostatin A	0-3	thyroglobulin	Homo sapiens	32-34
17679169-9	2007	ATRA repressed the TSH-R mRNA levels in the normal thyroid cell line and increased the TPO and Tg mRNA levels slightly in both the cell lines.	Tretinoin	0-4	thyroglobulin	Homo sapiens	95-97
17327138-0	2007	Modifying effects of iodine on the immunogenicity of thyroglobulin peptides.	Iodine	21-27	thyroglobulin	Homo sapiens	53-66
17327138-1	2007	We have previously shown that iodotyrosyl formation within thyroglobulin (Tg) generates neoantigenic determinants that are immunopathogenic.	iodotyrosyl	30-41	thyroglobulin	Homo sapiens	59-72
17327138-1	2007	We have previously shown that iodotyrosyl formation within thyroglobulin (Tg) generates neoantigenic determinants that are immunopathogenic.	iodotyrosyl	30-41	thyroglobulin	Homo sapiens	74-76
17327138-2	2007	In the current study, we have examined iodination effects on three tyrosyl-containing Tg peptides that are immunogenic in their non-iodinated form.	cyclo(tyrosyl-tyrosyl)	67-74	thyroglobulin	Homo sapiens	86-88
17327138-6	2007	Our results demonstrate that iodotyrosyl formation can exert variable effects on the immunogenic behavior of Tg epitopes which may not always result in enhanced pathology.	iodotyrosyl	29-40	thyroglobulin	Homo sapiens	109-111
17327138-7	2007	These findings also suggest that variations in the iodine content of Tg may significantly alter the hierarchy of antigenic determinants, to which the immune system may or may not be tolerant.	Iodine	51-57	thyroglobulin	Homo sapiens	69-71
17600477-5	2007	5-Aza increased TSH-R mRNA expression in both of the cell lines and decreased TPO, NIS, and Tg mRNA levels in the cancer cell line.	5-aza	0-5	thyroglobulin	Homo sapiens	92-94
17600477-7	2007	TSA treatment repressed NIS and Tg mRNA levels, and made no differences on other thyroid specific genes investigated in the cancer cell line.	trichostatin A	0-3	thyroglobulin	Homo sapiens	32-34
17600477-9	2007	ATRA repressed the TSH-R mRNA levels in the normal thyroid cell line and increased the TPO and Tg mRNA levels slightly in both cell lines.	Tretinoin	0-4	thyroglobulin	Homo sapiens	95-97
17325586-8	2007	Tg was assessed in eight patients, in whom two responders showed increased radioiodine uptake or no change and decreased Tg level, as well as PR after ATRA-induced differentiation therapy.	Iodine-131	75-86	thyroglobulin	Homo sapiens	0-2
17103166-1	2007	PURPOSE: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a well-established method in the follow-up of patients with differentiated thyroid carcinoma (DTC), elevated thyroglobulin (Tg) and negative 131I scans.	Fluorodeoxyglucose F18	9-31	thyroglobulin	Homo sapiens	185-198
17103166-1	2007	PURPOSE: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a well-established method in the follow-up of patients with differentiated thyroid carcinoma (DTC), elevated thyroglobulin (Tg) and negative 131I scans.	Fluorodeoxyglucose F18	33-36	thyroglobulin	Homo sapiens	185-198
17279579-2	2007	Furthermore, a growing number of patients with DTC have elevated Tg levels but no detectable disease on radioiodine scanning or other imaging studies.	dtc	47-50	thyroglobulin	Homo sapiens	65-67
17279579-3	2007	The objective of this study was to determine whether a gradient in Tg protein level exists in patients with DTC.	dtc	108-111	thyroglobulin	Homo sapiens	67-69
17279579-11	2007	The Tg ratio between the internal jugular and antecubital veins was significantly higher in patients with recurrent or persistent DTC than in patients with primary tumors (P = .0196).	dtc	130-133	thyroglobulin	Homo sapiens	4-6
17279579-13	2007	The findings suggested that venous sampling for Tg may be used to localize DTC in some patients who have high or increasing serum Tg levels but negative radioiodine scans or imaging studies.	dtc	75-78	thyroglobulin	Homo sapiens	48-50
17279579-13	2007	The findings suggested that venous sampling for Tg may be used to localize DTC in some patients who have high or increasing serum Tg levels but negative radioiodine scans or imaging studies.	dtc	75-78	thyroglobulin	Homo sapiens	130-132
17892441-3	2007	Recently, thyroglobulin measured during thyroxine treatment was found to be adequate for thyroid carcinoma follow-up if functional sensitivity at 0.2-0.3 ng/mL was reached by assay methods.	Thyroxine	40-49	thyroglobulin	Homo sapiens	10-23
17097689-0	2007	Presence of beta-linked GalNAc residues on N-glycans of human thyroglobulin.	beta-linked galnac	12-30	thyroglobulin	Homo sapiens	62-75
17097689-0	2007	Presence of beta-linked GalNAc residues on N-glycans of human thyroglobulin.	n-glycans	43-52	thyroglobulin	Homo sapiens	62-75
17097689-1	2007	Hepatic asialoglycoprotein receptor, which may mediate the clearance of circulating thyroglobulin, is known to have a high affinity for GalNAc.	N-acetylgalactosaminuronic acid	136-142	thyroglobulin	Homo sapiens	84-97
17097689-6	2007	Peptide N-glycanase treatment of human desialylated thyroglobulin resulted in the complete loss of reactivity with W. floribunda lectin, indicating that the binding sites are exclusively on N-glycans.	n-glycans	190-199	thyroglobulin	Homo sapiens	52-65
17097689-10	2007	GalNAc-specific Dolichos biflorus lectin also bound human thyroglobulin weakly.	N-acetylgalactosaminuronic acid	0-6	thyroglobulin	Homo sapiens	58-71
17097689-13	2007	These results strongly indicate the presence of distinct GalNAc termini of N-glycans on human thyroglobulin.	N-acetylgalactosaminuronic acid	57-63	thyroglobulin	Homo sapiens	94-107
17097689-13	2007	These results strongly indicate the presence of distinct GalNAc termini of N-glycans on human thyroglobulin.	n-glycans	75-84	thyroglobulin	Homo sapiens	94-107
17505148-0	2007	Possible reasons for different pattern disappearance of thyroglobulin and thyroid peroxidase autoantibodies in patients with differentiated thyroid carcinoma following total thyroidectomy and iodine-131 ablation.	Iodine	192-198	thyroglobulin	Homo sapiens	56-69
17505148-1	2007	The purpose of this study was to reveal some possible factors for the differences between the pattern of disappearance of thyroglobulin autoantibodies (anti-Tg) and thyroid peroxidase autoantibodies (anti-TPO) in patients with differentiated thyroid carcinoma following thyroidectomy and iodine-131 ablation.	Iodine	288-294	thyroglobulin	Homo sapiens	122-135
17665659-8	2007	One patient had diffuse lung metastases with high thyroglobulin level 600 ng/ml wich decreased after iodine 131 therapy.	Iodine	101-107	thyroglobulin	Homo sapiens	50-63
17188145-0	2006	A phase II trial of rosiglitazone in patients with thyroglobulin-positive and radioiodine-negative differentiated thyroid cancer.	Rosiglitazone	20-33	thyroglobulin	Homo sapiens	51-64
16870170-1	2006	Synthesis of tri-iodothyronine (T(3)) and thyroxine (T(4)) follows a metabolic pathway that depends on the integrity of the thyroglobulin structure.	Triiodothyronine	13-30	thyroglobulin	Homo sapiens	124-137
16870170-1	2006	Synthesis of tri-iodothyronine (T(3)) and thyroxine (T(4)) follows a metabolic pathway that depends on the integrity of the thyroglobulin structure.	Triiodothyronine	32-36	thyroglobulin	Homo sapiens	124-137
16870170-1	2006	Synthesis of tri-iodothyronine (T(3)) and thyroxine (T(4)) follows a metabolic pathway that depends on the integrity of the thyroglobulin structure.	Thyroxine	42-51	thyroglobulin	Homo sapiens	124-137
16968789-1	2006	CONTEXT: Thyroglobulin (Tg) may be a valuable indicator of improving thyroid function in children after salt iodization.	Salts	104-108	thyroglobulin	Homo sapiens	9-22
17199438-6	2006	RESULTS: Serum Tg levels while the patients were off thyroxine therapy decreased spontaneously in 39.3% of the cases without further therapy.	Thyroxine	53-62	thyroglobulin	Homo sapiens	15-17
17201802-10	2007	TSH-stimulated Tg levels before ablation and 6 months after initial therapy were independent prognostic indicators for death.	Thyrotropin	0-3	thyroglobulin	Homo sapiens	15-17
17188145-8	2006	CONCLUSIONS: Our findings suggest that rosiglitazone treatment may induce radioiodine uptake in some patients with thyroglobulin-positive and radioiodine-negative differentiated thyroid cancer.	Rosiglitazone	39-52	thyroglobulin	Homo sapiens	115-128
17188145-8	2006	CONCLUSIONS: Our findings suggest that rosiglitazone treatment may induce radioiodine uptake in some patients with thyroglobulin-positive and radioiodine-negative differentiated thyroid cancer.	Iodine-131	74-85	thyroglobulin	Homo sapiens	115-128
17309186-14	2006	Serum Tg was increased in all patients with local lymph node and distant metastases, visualized by (131)I or by (99m)Tc-MIBI, but also in 18 patients with thyroid remnants only.	Technetium Tc 99m Sestamibi	117-124	thyroglobulin	Homo sapiens	6-8
17043633-0	2006	Value of thyroglobulin to 131I uptake ratio in selection of initial therapy dose of 131I in patients with differentiated thyroid carcinoma.	Iodine-131	84-88	thyroglobulin	Homo sapiens	9-22
17309186-14	2006	Serum Tg was increased in all patients with local lymph node and distant metastases, visualized by (131)I or by (99m)Tc-MIBI, but also in 18 patients with thyroid remnants only.	thyroid remnants	155-171	thyroglobulin	Homo sapiens	6-8
17309186-15	2006	CONCLUSION: (99m)Tc-MIBI scan has been reported to be a highly sensitive technique for the detection of DTC metastases that have lost the capability to uptake (131)I; the combined (99m)Tc-MIBI scintigraphy and serum Tg estimation appear to be an alternative method of radioiodine imaging in cases with DTC and elevated Tg.	Technetium Tc 99m Sestamibi	17-24	thyroglobulin	Homo sapiens	216-218
17309186-15	2006	CONCLUSION: (99m)Tc-MIBI scan has been reported to be a highly sensitive technique for the detection of DTC metastases that have lost the capability to uptake (131)I; the combined (99m)Tc-MIBI scintigraphy and serum Tg estimation appear to be an alternative method of radioiodine imaging in cases with DTC and elevated Tg.	Technetium Tc 99m Sestamibi	17-24	thyroglobulin	Homo sapiens	319-321
17309186-15	2006	CONCLUSION: (99m)Tc-MIBI scan has been reported to be a highly sensitive technique for the detection of DTC metastases that have lost the capability to uptake (131)I; the combined (99m)Tc-MIBI scintigraphy and serum Tg estimation appear to be an alternative method of radioiodine imaging in cases with DTC and elevated Tg.	dtc	104-107	thyroglobulin	Homo sapiens	216-218
17309186-15	2006	CONCLUSION: (99m)Tc-MIBI scan has been reported to be a highly sensitive technique for the detection of DTC metastases that have lost the capability to uptake (131)I; the combined (99m)Tc-MIBI scintigraphy and serum Tg estimation appear to be an alternative method of radioiodine imaging in cases with DTC and elevated Tg.	dtc	104-107	thyroglobulin	Homo sapiens	319-321
17063797-10	2006	Of all the hormones observed, thyroglobulin was the best indicator of iodine retention in the organism.	Iodine	70-76	thyroglobulin	Homo sapiens	30-43
17042689-6	2006	The redifferentiating effect of RA was evaluated by serum thyroglobulin (Tg) monitoring during RA treatment and qualitative analysis of iodine uptake on the post-therapeutic whole body scan.	Tretinoin	32-34	thyroglobulin	Homo sapiens	58-71
16891093-9	2006	The typical indication to performing with examination is the DTC patient previously treated by total thyroidectomy and 131Iodine ablative therapy, with increased serum thyroglobulin (Tg) or anti-thyroglobulin (TgAb) antibodies during follow-up but with negative 131Iodine whole body scintigraphy even obtained after high, therapeutic 131Iodine doses.	dtc	61-64	thyroglobulin	Homo sapiens	168-181
16936513-1	2006	It is well known that under physiological conditions, the Tg molecule is the substrate for the hormones triiodothyronine and thyroxine.	Triiodothyronine	104-120	thyroglobulin	Homo sapiens	58-60
16936513-1	2006	It is well known that under physiological conditions, the Tg molecule is the substrate for the hormones triiodothyronine and thyroxine.	Thyroxine	125-134	thyroglobulin	Homo sapiens	58-60
16936513-8	2006	Compared with the controls (sudden unnatural deaths: Tg 23.3+/-27.6 ng/mL), the raised Tg values in the TBI cases were usually accompanied by a reduction in the intensity of immunohistochemical reactions relating to TSH and Tg.	Thyrotropin	216-219	thyroglobulin	Homo sapiens	87-89
16936513-8	2006	Compared with the controls (sudden unnatural deaths: Tg 23.3+/-27.6 ng/mL), the raised Tg values in the TBI cases were usually accompanied by a reduction in the intensity of immunohistochemical reactions relating to TSH and Tg.	Thyrotropin	216-219	thyroglobulin	Homo sapiens	87-89
16891093-9	2006	The typical indication to performing with examination is the DTC patient previously treated by total thyroidectomy and 131Iodine ablative therapy, with increased serum thyroglobulin (Tg) or anti-thyroglobulin (TgAb) antibodies during follow-up but with negative 131Iodine whole body scintigraphy even obtained after high, therapeutic 131Iodine doses.	dtc	61-64	thyroglobulin	Homo sapiens	195-208
16550594-9	2006	Scintigraphy with Tc-99m depreotide could prove a useful adjunct to the armamentarium for the follow-up of PTC, especially in the setting of detectable serum Tg and negative I-131 WBS.	Depreotide	25-35	thyroglobulin	Homo sapiens	158-160
16921272-1	2006	The effect of pretreatment with the peroxisome proliferator-activated receptor (PPAR) agonist, rosiglitazone, on radioiodine uptake and serum thyroglobulin levels in a patient with radioiodine-resistant papillary thyroid cancer is described.	Rosiglitazone	95-108	thyroglobulin	Homo sapiens	142-155
16550594-2	2006	The objective of this study was to evaluate the usefulness of scintiscan with the newer synthetic somatostatin analogue Tc-99m depreotide, in the restaging of papillary thyroid carcinoma (PTC) with detectable serum thyroglobulin (Tg) levels and negative I-131 whole-body scan (WBS).	Depreotide	127-137	thyroglobulin	Homo sapiens	215-228
16959467-2	2006	In the last American and European Consensus Conferences, a surveillance guideline has been extended to the use of thyrotropin (TSH)-stimulated Tg levels for thyroidectomized patients without clinical evidence of residual tumor with Tg below 1 microg/l during TSH suppression.	Thyrotropin	127-130	thyroglobulin	Homo sapiens	143-145
16959467-2	2006	In the last American and European Consensus Conferences, a surveillance guideline has been extended to the use of thyrotropin (TSH)-stimulated Tg levels for thyroidectomized patients without clinical evidence of residual tumor with Tg below 1 microg/l during TSH suppression.	Thyrotropin	127-130	thyroglobulin	Homo sapiens	232-234
16940367-4	2006	This case is a rare exception to the rule of Tg production as a prerequisite for differentiated thyroid cancers to concentrate radioiodine.	Iodine-131	127-138	thyroglobulin	Homo sapiens	45-47
17128567-0	2006	Importance of thyroglobulin levels for diagnosis and monitoring of follicular thyroid carcinoma in an adolescent with severe iodine deficiency.	Iodine	125-131	thyroglobulin	Homo sapiens	14-27
17006838-12	2006	CONCLUSIONS: First thyroglobulin concentration, determined after thyroidectomy but before other treatment, is higher in patients with metastatic DTC than in patients without such metastases.	dtc	145-148	thyroglobulin	Homo sapiens	19-32
17006844-3	2006	MATERIAL AND METHODS: Between 1999 and 2005, 13-cis-retinoic acid was used in 11 patients with disseminated PTC and high serum level of thyroglobulin (Tg) before (131)I treatment (2 patients were treated twice - 13 treatment cycles in total).	Isotretinoin	45-65	thyroglobulin	Homo sapiens	136-149
17006838-13	2006	This indicates that Tg level may be used as an early marker of either residual or metastatic DTC (even if thyroid remnants are present).	dtc	93-96	thyroglobulin	Homo sapiens	20-22
16794517-0	2006	Efficacy of radioiodine therapy in the treatment of elevated serum thyroglobulin in patients with differentiated thyroid carcinoma and negative whole-body iodine scan.	Iodine-131	12-23	thyroglobulin	Homo sapiens	67-80
16794517-0	2006	Efficacy of radioiodine therapy in the treatment of elevated serum thyroglobulin in patients with differentiated thyroid carcinoma and negative whole-body iodine scan.	Iodine	17-23	thyroglobulin	Homo sapiens	67-80
16794517-1	2006	INTRODUCTION: In the management of patients with differentiated thyroid carcinoma, serum thyroglobulin levels are often well correlated with whole-body radioiodine scanning (WBS) results.	Iodine-131	152-163	thyroglobulin	Homo sapiens	89-102
16794517-10	2006	CONCLUSION: We recommend that in differentiated thyroid carcinoma patients with elevated thyroglobulin and negative WBS, at least one course of radioiodine therapy should be undertaken and if reduction or normalization of serum thyroglobulin is not achieved, repeated courses of radioiodine therapy are not logical and other therapeutic methods should be applied.	Iodine-131	144-155	thyroglobulin	Homo sapiens	89-102
16628280-1	2006	Thyroxine (T4) withdrawal or recombinant TSH is used for the stimulation of thyroglobulin (Tg), whole-body scanning (WBS) and iodine-131 treatment in patients with thyroid carcinoma.	Thyroxine	0-9	thyroglobulin	Homo sapiens	76-89
17100547-4	2006	The clinical sensitivity of Tg is greatest when endogenous TSH is elevated before radioiodine imaging.	Thyrotropin	59-62	thyroglobulin	Homo sapiens	28-30
17100547-4	2006	The clinical sensitivity of Tg is greatest when endogenous TSH is elevated before radioiodine imaging.	Iodine-131	82-93	thyroglobulin	Homo sapiens	28-30
16839256-4	2006	MAIN OUTCOME: TSH stimulated the expression of thyroglobulin, peroxidase, sodium iodide symporter, vascular endothelial growth factor (VEGF)-A, VEGF-B, and placental growth factor (PGF) but decreased that of VEGF-C by half.	Thyrotropin	14-17	thyroglobulin	Homo sapiens	47-60
17137035-2	2006	The measurement of serum thyroglobulin (Tg) is considered for the post-surgical/radioiodine follow-up of papillary/follicular carcinomas.	Iodine-131	80-91	thyroglobulin	Homo sapiens	25-38
16205897-0	2006	Short-term outcome of differentiated thyroid cancer patients receiving a second iodine-131 therapy on the basis of a detectable serum thyroglobulin level after initial treatment.	Iodine-131	80-90	thyroglobulin	Homo sapiens	134-147
15902358-0	2005	Initial experience in use of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography in thyroid carcinoma patients with elevated serum thyroglobulin but negative iodine-131 whole body scans.	Fluorodeoxyglucose F18	29-59	thyroglobulin	Homo sapiens	159-172
16676403-0	2006	Early sequential changes in serum thyroglobulin after radioiodine ablation for thyroid cancer: possible clinical implications for recombinant human thyrotropin-aided therapy.	Iodine-131	54-65	thyroglobulin	Homo sapiens	34-47
16676403-2	2006	Recently, the thyroglobulin (Tg) value measured during hypothyroidism just before 131I therapy (preablation Tg) has proved to be effective for predicting persistent/recurrent disease.	Iodine-131	82-86	thyroglobulin	Homo sapiens	14-27
16681439-0	2006	Thyroglobulin assay during thyroxine treatment in low-risk differentiated thyroid cancer management: comparison with recombinant human thyrotropin-stimulated assay and imaging procedures.	Thyroxine	27-36	thyroglobulin	Homo sapiens	0-13
16681439-2	2006	Undetectable thyrotropin (TSH)-stimulated serum TG after thyroid ablation (i.e., thyroidectomy and radioiodine) implies the absence of residual or relapsing DTC.	Iodine-131	99-110	thyroglobulin	Homo sapiens	48-50
16681439-3	2006	Recently, high-cost recombinant human TSH (rhTSH) was proposed for TG stimulation to avoid uncomfortable thyroxine (T(4)) withdrawal.	Thyroxine	105-114	thyroglobulin	Homo sapiens	67-69
16477365-12	2006	Normal triiodothyronine and low thyroxine concentrations are often observed in patients with thyroglobulin gene mutations.	Triiodothyronine	7-23	thyroglobulin	Homo sapiens	93-106
16477365-12	2006	Normal triiodothyronine and low thyroxine concentrations are often observed in patients with thyroglobulin gene mutations.	Thyroxine	32-41	thyroglobulin	Homo sapiens	93-106
16477365-13	2006	We considered that some patients with thyroglobulin abnormality might have high triiodothyronine levels.	Triiodothyronine	80-96	thyroglobulin	Homo sapiens	38-51
16037381-0	2005	Role of sulfated tyrosines of thyroglobulin in thyroid hormonosynthesis.	Tyrosine	17-26	thyroglobulin	Homo sapiens	30-43
16284441-3	2005	Despite the severity of her condition, oral administration of vitamin D3 (alphacalcido) has stalled both the tumor growth and further increases of serum thyroglobulin (Tg) level, and has led to a good preservation of quality of life for the last two years.	Cholecalciferol	62-72	thyroglobulin	Homo sapiens	153-166
16284441-3	2005	Despite the severity of her condition, oral administration of vitamin D3 (alphacalcido) has stalled both the tumor growth and further increases of serum thyroglobulin (Tg) level, and has led to a good preservation of quality of life for the last two years.	Cholecalciferol	62-72	thyroglobulin	Homo sapiens	168-170
16000286-0	2005	Is empiric 131I therapy justified for patients with positive thyroglobulin and negative 131I whole-body scanning results?	Iodine-131	11-15	thyroglobulin	Homo sapiens	61-74
16409424-8	2006	The patients with a higher serum thyroglobulin level generally respond better to thyroxine-suppressive therapy.	Thyroxine	81-90	thyroglobulin	Homo sapiens	33-46
16477365-0	2006	A novel compound heterozygous mutation in the thyroglobulin gene resulting in congenital goitrous hypothyroidism with high serum triiodothyronine levels.	Triiodothyronine	129-145	thyroglobulin	Homo sapiens	46-59
16133388-0	2005	Prognostic value of an increase in the serum thyroglobulin level at the time of the first ablative radioiodine treatment in patients with differentiated thyroid cancer.	Iodine-131	99-110	thyroglobulin	Homo sapiens	45-58
16133388-1	2005	PURPOSE: The aim of this study was to assess the prognostic factors for treatment efficacy, and in particular the increase in serum thyroglobulin (Tg) level at the time of the first ablative radioiodine treatment, in patients with differentiated thyroid carcinoma (DTC).	Iodine-131	191-202	thyroglobulin	Homo sapiens	132-145
16133388-1	2005	PURPOSE: The aim of this study was to assess the prognostic factors for treatment efficacy, and in particular the increase in serum thyroglobulin (Tg) level at the time of the first ablative radioiodine treatment, in patients with differentiated thyroid carcinoma (DTC).	Iodine-131	191-202	thyroglobulin	Homo sapiens	147-149
16483183-3	2005	After two doses of radioiodine, thyroglobulin (Tg) remained detectable following recombinant human TSH (rhTSH) stimulation.	Iodine-131	19-30	thyroglobulin	Homo sapiens	32-45
16260597-0	2005	Mixed-disulfide folding intermediates between thyroglobulin and endoplasmic reticulum resident oxidoreductases ERp57 and protein disulfide isomerase.	Disulfides	6-15	thyroglobulin	Homo sapiens	46-59
16260597-1	2005	We present the first identification of transient folding intermediates of endogenous thyroglobulin (Tg; a large homodimeric secretory glycoprotein of thyrocytes), which include mixed disulfides with endogenous oxidoreductases servicing Tg folding needs.	Disulfides	183-193	thyroglobulin	Homo sapiens	85-98
16260597-1	2005	We present the first identification of transient folding intermediates of endogenous thyroglobulin (Tg; a large homodimeric secretory glycoprotein of thyrocytes), which include mixed disulfides with endogenous oxidoreductases servicing Tg folding needs.	Disulfides	183-193	thyroglobulin	Homo sapiens	100-102
16260597-2	2005	Formation of disulfide-linked Tg adducts with endoplasmic reticulum (ER) oxidoreductases begins cotranslationally.	Disulfides	13-22	thyroglobulin	Homo sapiens	30-32
15972576-8	2005	TSH-stimulated Tg fell spontaneously to less than 0.5 ng/ml in 50% of group 2 and 5% of group 3 over 1.7-5.0 yr.	Thyrotropin	0-3	thyroglobulin	Homo sapiens	15-17
15972576-12	2005	2) Repeated TSH-stimulated studies are appropriate for patients at risk of recurrence, especially those with an rhTSH-Tg greater than 1 ng/ml.	Thyrotropin	12-15	thyroglobulin	Homo sapiens	118-120
15972576-13	2005	3) A single rhTSH-Tg less than 0.5 ng/ml without Tg antibody has an approximately 98% likelihood of identifying patients completely free of tumor, a large group in which TSH suppression to less than 0.1 mIU/liter and frequent imaging and TSH-stimulated Tg testing are unnecessary.	Thyrotropin	14-17	thyroglobulin	Homo sapiens	18-20
15972576-13	2005	3) A single rhTSH-Tg less than 0.5 ng/ml without Tg antibody has an approximately 98% likelihood of identifying patients completely free of tumor, a large group in which TSH suppression to less than 0.1 mIU/liter and frequent imaging and TSH-stimulated Tg testing are unnecessary.	Thyrotropin	170-173	thyroglobulin	Homo sapiens	18-20
16157530-3	2005	Serum Tg levels during thyroid hormone withdrawal (Tg-off) are usually well correlated with the results of DWBS.	dwbs	107-111	thyroglobulin	Homo sapiens	6-8
16157530-6	2005	Negative (131)I DWBS and a positive Tg test (DWBS(-) Tg(+)) are found in most of these cases.	dwbs	45-49	thyroglobulin	Homo sapiens	36-38
16157530-7	2005	Positive (131)I DWBS and a negative Tg test (DWBS(+) Tg(-)), though of uncommon occurrence, has also been demonstrated in a small but significant number of cases.	dwbs	45-49	thyroglobulin	Homo sapiens	36-38
16157530-7	2005	Positive (131)I DWBS and a negative Tg test (DWBS(+) Tg(-)), though of uncommon occurrence, has also been demonstrated in a small but significant number of cases.	dwbs	45-49	thyroglobulin	Homo sapiens	53-55
16187904-2	2005	We tested the hypothesis that long-term exposure to perchlorate at these levels may cause a situation analogous to iodine deficiency, thus causing increases in thyrotropin (TSH) and thyroglobulin (Tg) levels and decreased levels of free thyroxine (FT4), in either the mother during the early stages of gestation or the neonate at birth, or in the fetus cause growth retardation.	perchlorate	52-63	thyroglobulin	Homo sapiens	182-195
16187904-2	2005	We tested the hypothesis that long-term exposure to perchlorate at these levels may cause a situation analogous to iodine deficiency, thus causing increases in thyrotropin (TSH) and thyroglobulin (Tg) levels and decreased levels of free thyroxine (FT4), in either the mother during the early stages of gestation or the neonate at birth, or in the fetus cause growth retardation.	Iodine	115-121	thyroglobulin	Homo sapiens	182-195
16000286-3	2005	Serum Tg levels during thyroid hormone withdrawal usually are correlated well with the results of DWBS.	dwbs	98-102	thyroglobulin	Homo sapiens	6-8
16000286-4	2005	In general, Tg levels undetectable by DWBS suggest complete remission, whereas detectable or elevated Tg concentrations are suggestive of the presence of 131I uptake in local or distant metastases.	Iodine-131	154-158	thyroglobulin	Homo sapiens	102-104
16000286-13	2005	More significantly, a decrease in Tg levels was achieved in 63% of DTC patients with Tg+ DWBS-, suggesting that 131I therapy does have a therapeutic effect when the Tg level is considered an index of tumor burden.	dwbs	89-93	thyroglobulin	Homo sapiens	34-36
16000286-15	2005	Therefore, 131I therapy may be justified in patients with Tg levels of &gt; 10 microg/L and DWBS- and who are at high risk of any recurrence.	Iodine-131	11-15	thyroglobulin	Homo sapiens	58-60
16117196-3	2005	In this study, our objectives were to determine the predictive factors for the development of high Tg and negative DxWBS (Tg+/scan-) and to study the long-term course of the disease in patients with this condition.	dxwbs	115-120	thyroglobulin	Homo sapiens	122-124
15902358-1	2005	INTRODUCTION: This study aims to examine the usefulness of fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in thyroid carcinoma patients with elevated serum thyroglobulin (Tg) but negative iodine-131 (I-131) whole body scans.	Fluorodeoxyglucose F18	59-89	thyroglobulin	Homo sapiens	204-217
15902358-1	2005	INTRODUCTION: This study aims to examine the usefulness of fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in thyroid carcinoma patients with elevated serum thyroglobulin (Tg) but negative iodine-131 (I-131) whole body scans.	Fluorodeoxyglucose F18	91-94	thyroglobulin	Homo sapiens	204-217
16437964-11	2005	131I was administrated to 28 patients (3,7 GBq as ablative dose): 11 of this received further radioiodine treatments (mean 7,4 GBq) because of elevated serum thyroglobulin levels and presence of loco-regional or lung metastasis at diagnostic total body scan after 131I treatment.	Iodine-131	0-4	thyroglobulin	Homo sapiens	158-171
16075925-3	2005	In support of this, we recently found that intact Tg is present in orbital tissues of patients with GO, where it is complexed with glycosaminoglycans.	Glycosaminoglycans	131-149	thyroglobulin	Homo sapiens	50-52
16075925-5	2005	Biotin-labeled Tg bound to both skin and orbital fibroblasts in a saturable manner, with constants of dissociation of approximately 75 nmol/l for skin fibroblasts and approximately 40 nmol/I for orbital fibroblasts.	Biotin	0-6	thyroglobulin	Homo sapiens	15-17
16075925-6	2005	In an attempt to identify Tg binding sites, fibroblast extracts were blotted onto membranes that were incubated with biotin-labeled Tg, which bound especially to a protein migrating at approximately 300 kDa, present in both orbital and skin fibroblast extracts.	Biotin	117-123	thyroglobulin	Homo sapiens	26-28
16075925-6	2005	In an attempt to identify Tg binding sites, fibroblast extracts were blotted onto membranes that were incubated with biotin-labeled Tg, which bound especially to a protein migrating at approximately 300 kDa, present in both orbital and skin fibroblast extracts.	Biotin	117-123	thyroglobulin	Homo sapiens	132-134
16116831-6	2005	One of these low-thyroglobulin patients developed recurrent disease involving cervical lymph nodes, with positive radioiodine scan: thyroglobulin remained undetectable.	Iodine-131	114-125	thyroglobulin	Homo sapiens	17-30
16116831-6	2005	One of these low-thyroglobulin patients developed recurrent disease involving cervical lymph nodes, with positive radioiodine scan: thyroglobulin remained undetectable.	Iodine-131	114-125	thyroglobulin	Homo sapiens	132-145
15730423-6	2005	In 32 patients the serum Tg ranged from 1 to 10 ng/ml: for these patients, the 131I TBS showed uptake foci in 26 and pathology disclosed neoplastic foci in 28.	131i tbs	79-87	thyroglobulin	Homo sapiens	25-27
15730423-7	2005	In 48 patients the serum Tg level was above 10 ng/ml: for these patients, the 131I TBS showed uptake foci in 38 and pathology disclosed neoplastic foci in 46.	131i tbs	78-86	thyroglobulin	Homo sapiens	25-27
16201895-5	2005	Serum thyroglobulin plays a pivotal role in thyroid carcinoma management after thyroid ablation (i.e., surgery and radioiodine) but is of limited value before these treatments.	Iodine-131	115-126	thyroglobulin	Homo sapiens	6-19
15613412-0	2005	Serum thyroglobulin levels at the time of 131I remnant ablation just after thyroidectomy are useful for early prediction of clinical recurrence in low-risk patients with differentiated thyroid carcinoma.	Iodine-131	42-46	thyroglobulin	Homo sapiens	6-19
16335684-8	2005	Immunohistochemical staining for Tg was performed on formalin-fixed, paraffin-embedded sections with anti-Tg antibodies.	Formaldehyde	53-61	thyroglobulin	Homo sapiens	33-35
16335684-8	2005	Immunohistochemical staining for Tg was performed on formalin-fixed, paraffin-embedded sections with anti-Tg antibodies.	Paraffin	69-77	thyroglobulin	Homo sapiens	33-35
16201895-7	2005	PATIENTS AND METHODS: Our study was undertaken in patients affected by pT1 papillary thyroid carcinoma to evaluate the predictive value of post-surgery thyroglobulin assay on 1) restaging immediately after radioiodine treatment and 2) restaging at 12 months.	Iodine-131	206-217	thyroglobulin	Homo sapiens	152-165
15579184-3	2004	Comparison of (131)I uptake test and thyroglobulin (Tg) off levothyroxine (L-T4) performed before therapy with post-therapy scans, in order to evaluate the ability to predict inappropriate treatments.	Thyroxine	60-73	thyroglobulin	Homo sapiens	37-50
15701340-0	2005	[F-18-fluordeoxyglucose positron emission tomography on patients with differentiated thyroid cancer who present elevated human serum thyroglobulin levels and negative I-131 whole body scan].	Fluorine	1-2	thyroglobulin	Homo sapiens	133-146
15701340-1	2005	UNLABELLED: This study aimed to evaluate the role of Fluorine-18-fluorodeoxyglucose positron emission tomography (PET-FDG) in patients with elevated serum thyroglobulin (hTg) levels where thyroid cancer tissue does not concentrate radioiodine, rendering false-negative results on I-131 scanning.	Fluorodeoxyglucose F18	53-83	thyroglobulin	Homo sapiens	155-168
15701340-1	2005	UNLABELLED: This study aimed to evaluate the role of Fluorine-18-fluorodeoxyglucose positron emission tomography (PET-FDG) in patients with elevated serum thyroglobulin (hTg) levels where thyroid cancer tissue does not concentrate radioiodine, rendering false-negative results on I-131 scanning.	Iodine-131	231-242	thyroglobulin	Homo sapiens	155-168
15761561-5	2004	Thyroglobulin (Tg) under thyroxine use was detectable in all patients without antibodies at a cut-off &gt; 1 ng/ml, in 90% at &gt; 5 ng/ml and in 80% at &gt; 10 ng/ml, and after thyroxine withdrawal in 100% at a cut-off &gt; 5 ng/ml and in 94% at &gt; 10 ng/ml.	Thyroxine	25-34	thyroglobulin	Homo sapiens	0-13
15761561-5	2004	Thyroglobulin (Tg) under thyroxine use was detectable in all patients without antibodies at a cut-off &gt; 1 ng/ml, in 90% at &gt; 5 ng/ml and in 80% at &gt; 10 ng/ml, and after thyroxine withdrawal in 100% at a cut-off &gt; 5 ng/ml and in 94% at &gt; 10 ng/ml.	Thyroxine	25-34	thyroglobulin	Homo sapiens	15-17
15761561-5	2004	Thyroglobulin (Tg) under thyroxine use was detectable in all patients without antibodies at a cut-off &gt; 1 ng/ml, in 90% at &gt; 5 ng/ml and in 80% at &gt; 10 ng/ml, and after thyroxine withdrawal in 100% at a cut-off &gt; 5 ng/ml and in 94% at &gt; 10 ng/ml.	Thyroxine	178-187	thyroglobulin	Homo sapiens	0-13
15761561-5	2004	Thyroglobulin (Tg) under thyroxine use was detectable in all patients without antibodies at a cut-off &gt; 1 ng/ml, in 90% at &gt; 5 ng/ml and in 80% at &gt; 10 ng/ml, and after thyroxine withdrawal in 100% at a cut-off &gt; 5 ng/ml and in 94% at &gt; 10 ng/ml.	Thyroxine	178-187	thyroglobulin	Homo sapiens	15-17
15232654-0	2004	Treatment of iodine-negative thyroglobulin-positive thyroid cancer: differences in outcome in patients with macrometastases and patients with micrometastases.	Iodine	13-19	thyroglobulin	Homo sapiens	29-42
15579752-2	2004	We hypothesized that the basal and TSH-stimulated Tg levels in patients with metastatic thyroid carcinoma would reflect tumor volume, histological subtype, and location of metastatic lesions.	Thyrotropin	35-38	thyroglobulin	Homo sapiens	50-52
15765025-2	2004	The Tg level becomes a specific and very sensitive marker of DTC recurrence: it is usually evaluated after eradication of thyroid residual tissue (by thyroidectomy and radiometabolic therapy), in presence of high level of TSH (&gt;35 microU/ml) obtained with the suspension of therapy or after rec-TSH administration and in absence of anti-Tg antibodies.	Thyrotropin	222-225	thyroglobulin	Homo sapiens	4-6
15765025-2	2004	The Tg level becomes a specific and very sensitive marker of DTC recurrence: it is usually evaluated after eradication of thyroid residual tissue (by thyroidectomy and radiometabolic therapy), in presence of high level of TSH (&gt;35 microU/ml) obtained with the suspension of therapy or after rec-TSH administration and in absence of anti-Tg antibodies.	Thyrotropin	298-301	thyroglobulin	Homo sapiens	4-6
15765026-14	2004	In low-risk DTC patients serum Tg after TSH stimulation, together with ultrasound of the neck, should be used to monitor persistent disease, avoiding diagnostic TBS which has a poor sensitivity.	Thyrotropin	40-43	thyroglobulin	Homo sapiens	31-33
15666427-0	2004	Partial withdrawal of levothyroxine to stimulate serum thyroglobulin for thyroid cancer monitoring.	Thyroxine	22-35	thyroglobulin	Homo sapiens	55-68
15232654-13	2004	CONCLUSION: Radioiodine treatment may have a beneficial therapeutic effect in patients who have elevated levels of serum Tg and negative d-WBS.	Iodine-131	12-23	thyroglobulin	Homo sapiens	121-123
15325268-3	2004	The early increase in the Tg synthesis within 1h after stimulation apparently triggers UPR as it is evidenced by the activation of ATF6- and PERK-dependent pathways of UPR and subsequent expression of the UPR target genes, ER molecular chaperones.	Hydrogen	46-48	thyroglobulin	Homo sapiens	26-28
15181134-1	2004	UNLABELLED: The aim of our study was to evaluate and compare in thyroid cancer patients the predictive value for disease progression of thyroglobulin (Tg) levels measured under thyroid-stimulating hormone (TSH) stimulation, in the postoperative period just before (131)I ablative therapy and at the time of control 6-12 mo later.	Thyrotropin	206-209	thyroglobulin	Homo sapiens	136-149
15256244-3	2004	The management of patients with isolated elevated Tg levels is controversial in the presence of negative radio-iodine scans.	Iodine	111-117	thyroglobulin	Homo sapiens	50-52
14991244-1	2004	In this prospective study, we evaluated the diagnostic and prognostic value of (111)In-octreotide scintigraphy (SRS) in papillary and follicular thyroid carcinoma (DTC) with increasing thyroglobulin (Tg) levels but no response to treatment with (131)I. Twenty-three consecutive patients (13 female, 10 male; mean age 55 years, range 13-81 years) with progressive DTC were selected for the study.	Octreotide	87-97	thyroglobulin	Homo sapiens	185-198
14991244-1	2004	In this prospective study, we evaluated the diagnostic and prognostic value of (111)In-octreotide scintigraphy (SRS) in papillary and follicular thyroid carcinoma (DTC) with increasing thyroglobulin (Tg) levels but no response to treatment with (131)I. Twenty-three consecutive patients (13 female, 10 male; mean age 55 years, range 13-81 years) with progressive DTC were selected for the study.	Ditiocarb	164-167	thyroglobulin	Homo sapiens	185-198
15497927-6	2004	RESULTS: Tg mRNA and serum Tg were detected in twelve patients with differentiated thyroid cancer (DTC) after thyroidectomy and radioiodine therapy, however, there was no correlation with the clinical stage.	Iodine-131	128-139	thyroglobulin	Homo sapiens	9-11
15497927-6	2004	RESULTS: Tg mRNA and serum Tg were detected in twelve patients with differentiated thyroid cancer (DTC) after thyroidectomy and radioiodine therapy, however, there was no correlation with the clinical stage.	Iodine-131	128-139	thyroglobulin	Homo sapiens	27-29
15497927-10	2004	CONCLUSIONS: Our data suggests that RT-PCR detects Tg mRNA of extrathyroidal origin, from leukocytes or from metastasizing carcinoma cells under basal conditions or after TSH stimulation.	Thyrotropin	171-174	thyroglobulin	Homo sapiens	51-53
15096179-9	2004	More than half of them are located within the acetylcholinesterase-homologous domain of thyroglobulin, and overlap B-cell epitopes associated with autoimmune thyroid disease, while the others are located within cysteine-rich repeats.	Cysteine	211-219	thyroglobulin	Homo sapiens	88-101
15761510-6	2004	In patients with Tg &lt;1 ng/ml, 2.8% showed cervical lymph nodes Mt.	Leu-Thr	21-23	thyroglobulin	Homo sapiens	17-19
15283689-6	2004	Tg measurement in basal conditions during L-thyroxine suppression therapy and 5 days after recombinant human TSH stimulation was performed in 22 patients with DTC.	dtc	159-162	thyroglobulin	Homo sapiens	0-2
15226452-5	2004	Thyroglobulin is a promising new biochemical indicator for monitoring thyroid function after the introduction of iodized salt.	Salts	121-125	thyroglobulin	Homo sapiens	0-13
15640901-0	2004	[Usefulness of radioiodine scanning in patients with moderate/high risk differentiated thyroid carcinoma in whom thyroglobulin after thyroxin withdrawal is undetectable after initial treatment].	Iodine-131	15-26	thyroglobulin	Homo sapiens	113-126
14976143-0	2004	Histone deacetylase inhibitors restore radioiodide uptake and retention in poorly differentiated and anaplastic thyroid cancer cells by expression of the sodium/iodide symporter thyroperoxidase and thyroglobulin.	radioiodide	39-50	thyroglobulin	Homo sapiens	198-211
14976143-2	2004	Upon iodide uptake, thyroperoxidase catalyzes iodination of tyrosine residues in thyroglobulin, retaining iodide within thyroid follicles.	Iodides	5-11	thyroglobulin	Homo sapiens	81-94
14976143-2	2004	Upon iodide uptake, thyroperoxidase catalyzes iodination of tyrosine residues in thyroglobulin, retaining iodide within thyroid follicles.	Tyrosine	60-68	thyroglobulin	Homo sapiens	81-94
14976143-2	2004	Upon iodide uptake, thyroperoxidase catalyzes iodination of tyrosine residues in thyroglobulin, retaining iodide within thyroid follicles.	Iodides	106-112	thyroglobulin	Homo sapiens	81-94
14976143-8	2004	In an attempt to determine the mechanism by which these gene expressions occurred, we detected the inhibition of protein synthesis by cycloheximide, which up-regulated the expression of thyroperoxidase and thyroglobulin mRNA in HDACI-treated cells and down-regulated that of sodium/iodide symporter mRNA.	Cycloheximide	134-147	thyroglobulin	Homo sapiens	206-219
14976143-8	2004	In an attempt to determine the mechanism by which these gene expressions occurred, we detected the inhibition of protein synthesis by cycloheximide, which up-regulated the expression of thyroperoxidase and thyroglobulin mRNA in HDACI-treated cells and down-regulated that of sodium/iodide symporter mRNA.	hdaci	228-233	thyroglobulin	Homo sapiens	206-219
14976143-8	2004	In an attempt to determine the mechanism by which these gene expressions occurred, we detected the inhibition of protein synthesis by cycloheximide, which up-regulated the expression of thyroperoxidase and thyroglobulin mRNA in HDACI-treated cells and down-regulated that of sodium/iodide symporter mRNA.	Sodium Iodide	275-288	thyroglobulin	Homo sapiens	206-219
15051609-8	2004	One year after the introduction of IS, median urinary iodine and thyroglobulin concentrations had normalized, mean thyroid volume had decreased by 34%, and median thyrotropin and mean total thyroxine concentrations were improved.	iodized salt	35-37	thyroglobulin	Homo sapiens	65-78
15181134-1	2004	UNLABELLED: The aim of our study was to evaluate and compare in thyroid cancer patients the predictive value for disease progression of thyroglobulin (Tg) levels measured under thyroid-stimulating hormone (TSH) stimulation, in the postoperative period just before (131)I ablative therapy and at the time of control 6-12 mo later.	Thyrotropin	206-209	thyroglobulin	Homo sapiens	151-153
15233552-6	2004	Three parameters for assessment of RA effects were established: a) reduction of serum thyroglobulin levels; b) increment of the post-therapeutic dose radioiodine uptake; c) tumor size regression after therapy.	Tretinoin	35-37	thyroglobulin	Homo sapiens	86-99
15070908-8	2004	Tg increased over baseline during the first 4 months of AR by 17.0 +/- 4.6% and after 7 more months by 31.7 +/- 4.3% over baseline in the placebo group of both cohorts (P &lt; 0.0002).	Argon	56-58	thyroglobulin	Homo sapiens	0-2
15070908-11	2004	The rise in Tg with TSH and the reduction in Tg with L-T(4) provide evidence of target tissue response to TSH and further confirm the TSH rise as physiologically significant.	Thyrotropin	20-23	thyroglobulin	Homo sapiens	12-14
15070908-11	2004	The rise in Tg with TSH and the reduction in Tg with L-T(4) provide evidence of target tissue response to TSH and further confirm the TSH rise as physiologically significant.	Thyrotropin	106-109	thyroglobulin	Homo sapiens	12-14
15070908-11	2004	The rise in Tg with TSH and the reduction in Tg with L-T(4) provide evidence of target tissue response to TSH and further confirm the TSH rise as physiologically significant.	Thyrotropin	106-109	thyroglobulin	Homo sapiens	45-47
15070908-11	2004	The rise in Tg with TSH and the reduction in Tg with L-T(4) provide evidence of target tissue response to TSH and further confirm the TSH rise as physiologically significant.	Thyrotropin	106-109	thyroglobulin	Homo sapiens	12-14
15070908-11	2004	The rise in Tg with TSH and the reduction in Tg with L-T(4) provide evidence of target tissue response to TSH and further confirm the TSH rise as physiologically significant.	Thyrotropin	106-109	thyroglobulin	Homo sapiens	45-47
15118274-5	2004	Serum thyroglobulin (Tg) levels under thyroxine treatment of patients with lung metastases had to be over 1.5 ng/mL.	Thyroxine	38-47	thyroglobulin	Homo sapiens	6-19
15118274-5	2004	Serum thyroglobulin (Tg) levels under thyroxine treatment of patients with lung metastases had to be over 1.5 ng/mL.	Thyroxine	38-47	thyroglobulin	Homo sapiens	21-23
14751038-4	2003	Markedly high FNAB thyroglobulin (Tg) values were found in all metastatic CLN TC.	colostrinine	74-77	thyroglobulin	Homo sapiens	19-32
15611814-5	2004	Thus, thyroid iodide organification depends on TPO activity, which is modulated by the concentration of substrates (thyroglobulin and iodide) and cofactor (hydrogen peroxide).	thyroid iodide	6-20	thyroglobulin	Homo sapiens	116-129
15611814-5	2004	Thus, thyroid iodide organification depends on TPO activity, which is modulated by the concentration of substrates (thyroglobulin and iodide) and cofactor (hydrogen peroxide).	Iodides	14-20	thyroglobulin	Homo sapiens	116-129
15074368-5	2004	Iodine deficiency with high prevalence of goiter, low urinary iodine excretion and high serum thyroglobulin concentrations were recognized among pregnant women and their babies in Kayseri.	Iodine	0-6	thyroglobulin	Homo sapiens	94-107
14629818-5	2003	In patients with elevated thyroglobulin and negative scans with radioactive iodine, there is increasing evidence that positron emission tomography (PET) is helpful in locating the site of thyroglobulin production.	radioactive iodine	64-82	thyroglobulin	Homo sapiens	188-201
12915634-12	2003	After birth of the two affected siblings, genomic DNA sequencing identified the presence of compound heterozygous mutations of the Tg gene: the paternal mutation consists of a cytosine deletion at nucleotide 1143 in exon 9 (1143delC), resulting in a frameshift that generates a stop codon at position 382, and the maternal mutation is a guanine to adenine substitution at position 6725 in exon 38, creating the R2223H missense mutation in the acetylcholinesterase homology domain of Tg.	Guanine	337-344	thyroglobulin	Homo sapiens	131-133
14557483-0	2003	Correlation between the loss of thyroglobulin iodination and the expression of thyroid-specific proteins involved in iodine metabolism in thyroid carcinomas.	Iodine	117-123	thyroglobulin	Homo sapiens	32-45
14759077-0	2003	Three-week thyroxine withdrawal thyroglobulin stimulation screening test to detect low-risk residual/recurrent well-differentiated thyroid carcinoma.	Thyroxine	11-20	thyroglobulin	Homo sapiens	32-45
14759077-1	2003	Measurement of serum TSH-stimulated thyroglobulin (Tg) is recognized as a sensitive method for detecting residual/recurrent well-differentiated thyroid carcinoma (WDTC) in patients previously treated by surgery and radioactive iodine (RAI) ablation therapy.	Thyrotropin	21-24	thyroglobulin	Homo sapiens	36-49
14759077-1	2003	Measurement of serum TSH-stimulated thyroglobulin (Tg) is recognized as a sensitive method for detecting residual/recurrent well-differentiated thyroid carcinoma (WDTC) in patients previously treated by surgery and radioactive iodine (RAI) ablation therapy.	Thyrotropin	21-24	thyroglobulin	Homo sapiens	51-53
14759077-1	2003	Measurement of serum TSH-stimulated thyroglobulin (Tg) is recognized as a sensitive method for detecting residual/recurrent well-differentiated thyroid carcinoma (WDTC) in patients previously treated by surgery and radioactive iodine (RAI) ablation therapy.	radioactive iodine	215-233	thyroglobulin	Homo sapiens	36-49
14759077-1	2003	Measurement of serum TSH-stimulated thyroglobulin (Tg) is recognized as a sensitive method for detecting residual/recurrent well-differentiated thyroid carcinoma (WDTC) in patients previously treated by surgery and radioactive iodine (RAI) ablation therapy.	radioactive iodine	215-233	thyroglobulin	Homo sapiens	51-53
14759077-1	2003	Measurement of serum TSH-stimulated thyroglobulin (Tg) is recognized as a sensitive method for detecting residual/recurrent well-differentiated thyroid carcinoma (WDTC) in patients previously treated by surgery and radioactive iodine (RAI) ablation therapy.	Insulin, Short-Acting	235-238	thyroglobulin	Homo sapiens	36-49
14759077-1	2003	Measurement of serum TSH-stimulated thyroglobulin (Tg) is recognized as a sensitive method for detecting residual/recurrent well-differentiated thyroid carcinoma (WDTC) in patients previously treated by surgery and radioactive iodine (RAI) ablation therapy.	Insulin, Short-Acting	235-238	thyroglobulin	Homo sapiens	51-53
14588099-0	2003	Glycosaminoglycans provide a binding site for thyroglobulin in orbital tissues of patients with thyroid-associated ophthalmopathy.	Glycosaminoglycans	0-18	thyroglobulin	Homo sapiens	46-59
14588099-5	2003	Orbital tissue extracts from TAO patients that contained Tg were subjected to high-salt treatment, which resulted in separation of Tg from GAGs, as observed by column chromatography.	Salts	83-87	thyroglobulin	Homo sapiens	57-59
14588099-5	2003	Orbital tissue extracts from TAO patients that contained Tg were subjected to high-salt treatment, which resulted in separation of Tg from GAGs, as observed by column chromatography.	Salts	83-87	thyroglobulin	Homo sapiens	131-133
14588100-4	2003	In 5 patients, Tg levels increased to more than 2 times the starting Tg level over the study period and in 4 of these 5, there was recurrence of DTC.	dtc	145-148	thyroglobulin	Homo sapiens	15-17
14588100-6	2003	Our results suggest that serial measurements of low levels of Tg by ELISA in treated patients with DTC enable detection of recurrence (without using TSH stimulation) 6-12 months earlier than would have been possible using a conventional Tg immuno-radiometric assay (IRMA).	dtc	99-102	thyroglobulin	Homo sapiens	62-64
14588100-6	2003	Our results suggest that serial measurements of low levels of Tg by ELISA in treated patients with DTC enable detection of recurrence (without using TSH stimulation) 6-12 months earlier than would have been possible using a conventional Tg immuno-radiometric assay (IRMA).	Thyrotropin	149-152	thyroglobulin	Homo sapiens	62-64
14588101-5	2003	We measured Tg mRNA in 26 patients undergoing levothyroxine (LT(4)) suppressive therapy after total thyroidectomy for thyroid cancer and in 11 controls.	Thyroxine	46-59	thyroglobulin	Homo sapiens	12-14
14521888-0	2003	Technetium-99m tetrofosmin single photon emission computed tomography to detect metastatic papillary thyroid carcinoma in patients with elevated human serum thyroglobulin levels but negative I-131 whole body scan.	Technetium	0-10	thyroglobulin	Homo sapiens	157-170
14521888-0	2003	Technetium-99m tetrofosmin single photon emission computed tomography to detect metastatic papillary thyroid carcinoma in patients with elevated human serum thyroglobulin levels but negative I-131 whole body scan.	Tetrofosmin	15-26	thyroglobulin	Homo sapiens	157-170
14521888-1	2003	AIM: The aim of this study was to evaluate the effectiveness of technetium-99m tetrofosmin (Tc-99m TF) single photon emission computed tomography (SPECT) of the neck and chest to detect metastatic lesions in papillary thyroid carcinoma (PTC) after near total thyroidectomy and radioiodine (I-131) treatment in patients who present with elevated serum human thyroglobulin (hTg) levels but negative I-131 whole body scan (WBS).	Technetium-99	64-77	thyroglobulin	Homo sapiens	357-370
14521888-1	2003	AIM: The aim of this study was to evaluate the effectiveness of technetium-99m tetrofosmin (Tc-99m TF) single photon emission computed tomography (SPECT) of the neck and chest to detect metastatic lesions in papillary thyroid carcinoma (PTC) after near total thyroidectomy and radioiodine (I-131) treatment in patients who present with elevated serum human thyroglobulin (hTg) levels but negative I-131 whole body scan (WBS).	Tetrofosmin	79-90	thyroglobulin	Homo sapiens	357-370
14521888-1	2003	AIM: The aim of this study was to evaluate the effectiveness of technetium-99m tetrofosmin (Tc-99m TF) single photon emission computed tomography (SPECT) of the neck and chest to detect metastatic lesions in papillary thyroid carcinoma (PTC) after near total thyroidectomy and radioiodine (I-131) treatment in patients who present with elevated serum human thyroglobulin (hTg) levels but negative I-131 whole body scan (WBS).	Technetium	92-94	thyroglobulin	Homo sapiens	357-370
12915634-12	2003	After birth of the two affected siblings, genomic DNA sequencing identified the presence of compound heterozygous mutations of the Tg gene: the paternal mutation consists of a cytosine deletion at nucleotide 1143 in exon 9 (1143delC), resulting in a frameshift that generates a stop codon at position 382, and the maternal mutation is a guanine to adenine substitution at position 6725 in exon 38, creating the R2223H missense mutation in the acetylcholinesterase homology domain of Tg.	Adenine	348-355	thyroglobulin	Homo sapiens	131-133
12699436-1	2003	BACKGROUND: Serum thyroglobulin (Tg) measurement after TSH stimulation, by either thyroid hormone withdrawal or recombinant human TSH (rhTSH) administration, is the most sensitive method for early detection of patients with persistent or recurrent differentiated thyroid cancer (DTC) after total thyroidectomy and 131I ablation.	Thyrotropin	55-58	thyroglobulin	Homo sapiens	18-31
12843145-4	2003	With the current trend to treat some thyroid cancer patients with radioiodine on the basis of an elevated serum Tg result alone, this has the potential to result in unwarranted therapy.	Iodine-131	66-77	thyroglobulin	Homo sapiens	112-114
12843145-9	2003	After HBT treatment, Tg levels dropped to less than 1 ng/ml in 32 specimens (P &lt; 0.0000001), 20 of which fell to less than 0.1 ng/ml (P &lt; 0.00002).	hbt	6-9	thyroglobulin	Homo sapiens	21-23
12899791-1	2003	OBJECTIVE: To investigate the correlation between serum thyroglobulin (Tg) and thyroid stimulating hormone (TSH) in populations with non-toxic goiter.	Thyrotropin	79-106	thyroglobulin	Homo sapiens	56-69
12899791-1	2003	OBJECTIVE: To investigate the correlation between serum thyroglobulin (Tg) and thyroid stimulating hormone (TSH) in populations with non-toxic goiter.	Thyrotropin	79-106	thyroglobulin	Homo sapiens	71-73
12899791-1	2003	OBJECTIVE: To investigate the correlation between serum thyroglobulin (Tg) and thyroid stimulating hormone (TSH) in populations with non-toxic goiter.	Thyrotropin	108-111	thyroglobulin	Homo sapiens	56-69
12899791-1	2003	OBJECTIVE: To investigate the correlation between serum thyroglobulin (Tg) and thyroid stimulating hormone (TSH) in populations with non-toxic goiter.	Thyrotropin	108-111	thyroglobulin	Homo sapiens	71-73
12791623-9	2003	Median thyroglobulin was 24.5 (range: 0-328.8) micro g/L at baseline and fell significantly after the introduction of iodized salt to 6.2 (0-83.1) and 4.4 (0-47.1) micro g/L at 5 and 12 mo, respectively (P &lt; 0.0001).	Salts	126-130	thyroglobulin	Homo sapiens	7-20
12791623-10	2003	Regression of urinary iodine and thyroid volume on thyroglobulin was highly significant at baseline and at 5 mo (P &lt; 0.001).	Iodine	22-28	thyroglobulin	Homo sapiens	51-64
12791623-11	2003	CONCLUSION: Thyroglobulin, measured in dried whole blood spots, may be a valuable indicator of improving thyroid function in children after supplementation with iodized salt.	Salts	169-173	thyroglobulin	Homo sapiens	12-25
12782763-9	2003	In patients studied prospectively over a 12 month period, there was a significant correlation between detectable Tg mRNA in peripheral blood and the presence or absence of metastatic disease, as demonstrated by radioiodine scanning.	Iodine-131	211-222	thyroglobulin	Homo sapiens	113-115
12699443-15	2003	CONCLUSIONS: The incidences of FT4 concentrations more than 2SD below the control mean and of Tg &gt; 2SD above the control mean are significantly increased in hypothyroid mothers in iodlne-sufficient New England.	iodlne	183-189	thyroglobulin	Homo sapiens	94-96
12699443-17	2003	Indeed, concentrations for FT4, Tg and Tg antibodies for nonpregnant and pregnant controls in our iodine-replete area do not differ significantly from each other or from previously reported normative concentrations with the methods used.	Iodine	98-104	thyroglobulin	Homo sapiens	39-41
12699436-1	2003	BACKGROUND: Serum thyroglobulin (Tg) measurement after TSH stimulation, by either thyroid hormone withdrawal or recombinant human TSH (rhTSH) administration, is the most sensitive method for early detection of patients with persistent or recurrent differentiated thyroid cancer (DTC) after total thyroidectomy and 131I ablation.	Thyrotropin	130-133	thyroglobulin	Homo sapiens	18-31
12914294-0	2003	[Serum thyroglobulin measurement utility in the surveillance for iodine status].	Iodine	65-71	thyroglobulin	Homo sapiens	7-20
12856803-0	2003	F18-fluorodeoxyglucose positron emission tomography in detecting metastatic papillary thyroid carcinoma with elevated human serum thyroglobulin levels but negative I-131 whole body scan.	Fluorodeoxyglucose F18	0-22	thyroglobulin	Homo sapiens	130-143
12856803-4	2003	METHODS: The aim of this study is to evaluate the effectiveness of F18-fluorodeoxyglucose (FDG) positron emission tomography (PET) to detect metastatic lesions in patients with papillary thyroid carcinomas (PTC) after nearly total thyroidectomy and I-131 treatments who present with elevated human serum thyroglobulin (hTg) levels but negative 1-131 whole body scan (WBS).	Fluorodeoxyglucose F18	67-89	thyroglobulin	Homo sapiens	304-317
12856803-4	2003	METHODS: The aim of this study is to evaluate the effectiveness of F18-fluorodeoxyglucose (FDG) positron emission tomography (PET) to detect metastatic lesions in patients with papillary thyroid carcinomas (PTC) after nearly total thyroidectomy and I-131 treatments who present with elevated human serum thyroglobulin (hTg) levels but negative 1-131 whole body scan (WBS).	Fluorodeoxyglucose F18	91-94	thyroglobulin	Homo sapiens	304-317
12882712-5	2003	An elevated serum TG was found in both the communities with deficient iodine intake and excessive iodine intake.	Iodine	70-76	thyroglobulin	Homo sapiens	18-20
12914294-2	2003	The utility of serum thyroglobulin in the screening for the iodine deficiency disorder, excess iodine was analyzed, and advantages and limitations were also summarized.	Iodine	60-66	thyroglobulin	Homo sapiens	21-34
12882712-5	2003	An elevated serum TG was found in both the communities with deficient iodine intake and excessive iodine intake.	Iodine	98-104	thyroglobulin	Homo sapiens	18-20
12914294-3	2003	Serum thyroglobulin was more sensitive than serum thyrotropin in the feedback of iodine status and a useful indicator deserved to be recommend.	Iodine	81-87	thyroglobulin	Homo sapiens	6-19
12882712-9	2003	An increased serum TG was found in subjects of aged 50 in the community with deficient iodine intake.	Iodine	87-93	thyroglobulin	Homo sapiens	19-21
12641624-7	2003	MEASUREMENTS: We compared serum Tg levels measured at less than 3 months before the administration of therapeutic doses of 131I or DxWBS with the levels at 6-12 months after administration between two groups.	Iodine-131	123-127	thyroglobulin	Homo sapiens	32-34
12882712-10	2003	CONCLUSION: Serum TG level is affected by gender, amount of iodine intake, serum TSH level and thyroid volume.	Iodine	60-66	thyroglobulin	Homo sapiens	18-20
12882712-10	2003	CONCLUSION: Serum TG level is affected by gender, amount of iodine intake, serum TSH level and thyroid volume.	Thyrotropin	81-84	thyroglobulin	Homo sapiens	18-20
12641624-14	2003	CONCLUSIONS: This study revealed that the administration of therapeutic doses of 131I has a therapeutic effect, at least for palliation in short-term observation, considering the serum Tg level as an index of tumour burden, and that it can disclose previously undiagnosed lesion in some patients with differentiated thyroid cancer who show elevated thyroglobulin level but negative diagnostic 131I whole-body scan.	Iodine-131	81-85	thyroglobulin	Homo sapiens	185-187
12641624-0	2003	Effects of therapeutic doses of 131I in thyroid papillary carcinoma patients with elevated thyroglobulin level and negative 131I whole-body scan: comparative study.	Iodine-131	32-36	thyroglobulin	Homo sapiens	91-104
12641624-14	2003	CONCLUSIONS: This study revealed that the administration of therapeutic doses of 131I has a therapeutic effect, at least for palliation in short-term observation, considering the serum Tg level as an index of tumour burden, and that it can disclose previously undiagnosed lesion in some patients with differentiated thyroid cancer who show elevated thyroglobulin level but negative diagnostic 131I whole-body scan.	Iodine-131	81-85	thyroglobulin	Homo sapiens	349-362
12641624-1	2003	OBJECTIVE: Previous studies have shown a high rate of visualization of uptake and a decrease in serum thyroglobulin (Tg) after therapeutic doses of 131I in well-differentiated thyroid cancer patients with elevated thyroglobulinaemia but negative diagnostic 131I whole-body scan (DxWBS), but its therapeutic effect remains controversial.	Iodine-131	148-152	thyroglobulin	Homo sapiens	102-115
12641624-1	2003	OBJECTIVE: Previous studies have shown a high rate of visualization of uptake and a decrease in serum thyroglobulin (Tg) after therapeutic doses of 131I in well-differentiated thyroid cancer patients with elevated thyroglobulinaemia but negative diagnostic 131I whole-body scan (DxWBS), but its therapeutic effect remains controversial.	Iodine-131	148-152	thyroglobulin	Homo sapiens	117-119
12679418-4	2003	An undetectable serum Tg measured during thyroid hormone suppression of TSH (THST) is often misleading.	Thyrotropin	72-75	thyroglobulin	Homo sapiens	22-24
12641624-1	2003	OBJECTIVE: Previous studies have shown a high rate of visualization of uptake and a decrease in serum thyroglobulin (Tg) after therapeutic doses of 131I in well-differentiated thyroid cancer patients with elevated thyroglobulinaemia but negative diagnostic 131I whole-body scan (DxWBS), but its therapeutic effect remains controversial.	Iodine-131	257-261	thyroglobulin	Homo sapiens	117-119
12641624-1	2003	OBJECTIVE: Previous studies have shown a high rate of visualization of uptake and a decrease in serum thyroglobulin (Tg) after therapeutic doses of 131I in well-differentiated thyroid cancer patients with elevated thyroglobulinaemia but negative diagnostic 131I whole-body scan (DxWBS), but its therapeutic effect remains controversial.	dxwbs	279-284	thyroglobulin	Homo sapiens	102-115
12641624-1	2003	OBJECTIVE: Previous studies have shown a high rate of visualization of uptake and a decrease in serum thyroglobulin (Tg) after therapeutic doses of 131I in well-differentiated thyroid cancer patients with elevated thyroglobulinaemia but negative diagnostic 131I whole-body scan (DxWBS), but its therapeutic effect remains controversial.	dxwbs	279-284	thyroglobulin	Homo sapiens	117-119
12641624-2	2003	We evaluate the effect of therapeutic doses of 131I in patients with elevated thyroglobulin level but negative DxWBS.	Iodine-131	47-51	thyroglobulin	Homo sapiens	78-91
12641624-3	2003	DESIGN: Among papillary thyroid carcinoma patients who underwent total or near-total thyroidectomy and remnant ablation with radioiodine during 1996 to 2000 in our hospital, the patients who showed elevated serum Tg levels and no abnormal uptake in DxWBS were selected.	Iodine-131	125-136	thyroglobulin	Homo sapiens	213-215
12679418-4	2003	An undetectable serum Tg measured during thyroid hormone suppression of TSH (THST) is often misleading.	thst	77-81	thyroglobulin	Homo sapiens	22-24
12679418-5	2003	Eight studies show that 21% of 784 patients who had no clinical evidence of tumor with baseline serum Tg levels usually below 1 micro g/liter during THST had, in response to recombinant human TSH (rhTSH), a rise in serum Tg to more than 2 micro g/liter.	thst	149-153	thyroglobulin	Homo sapiens	102-104
12679418-5	2003	Eight studies show that 21% of 784 patients who had no clinical evidence of tumor with baseline serum Tg levels usually below 1 micro g/liter during THST had, in response to recombinant human TSH (rhTSH), a rise in serum Tg to more than 2 micro g/liter.	Thyrotropin	192-195	thyroglobulin	Homo sapiens	102-104
12679418-5	2003	Eight studies show that 21% of 784 patients who had no clinical evidence of tumor with baseline serum Tg levels usually below 1 micro g/liter during THST had, in response to recombinant human TSH (rhTSH), a rise in serum Tg to more than 2 micro g/liter.	Thyrotropin	192-195	thyroglobulin	Homo sapiens	221-223
12679418-8	2003	Ten studies comprising 1599 patients demonstrate that a TSH-stimulated Tg test using a Tg cutoff of 2 micro g/liter (either after thyroid hormone withdrawal or 72 h after rhTSH) is sufficiently sensitive to be used as the principal test in the follow-up management of low-risk patients with DTC and that the routine use of diagnostic whole body scanning in follow-up should be discouraged.	Thyrotropin	56-59	thyroglobulin	Homo sapiens	71-73
12679418-8	2003	Ten studies comprising 1599 patients demonstrate that a TSH-stimulated Tg test using a Tg cutoff of 2 micro g/liter (either after thyroid hormone withdrawal or 72 h after rhTSH) is sufficiently sensitive to be used as the principal test in the follow-up management of low-risk patients with DTC and that the routine use of diagnostic whole body scanning in follow-up should be discouraged.	Thyrotropin	56-59	thyroglobulin	Homo sapiens	87-89
12679418-8	2003	Ten studies comprising 1599 patients demonstrate that a TSH-stimulated Tg test using a Tg cutoff of 2 micro g/liter (either after thyroid hormone withdrawal or 72 h after rhTSH) is sufficiently sensitive to be used as the principal test in the follow-up management of low-risk patients with DTC and that the routine use of diagnostic whole body scanning in follow-up should be discouraged.	dtc	291-294	thyroglobulin	Homo sapiens	71-73
12679418-9	2003	On the basis of the foregoing, we propose a surveillance guideline using TSH-stimulated Tg levels for patients who have undergone total or near-total thyroidectomy and (131)I ablation for DTC and have no clinical evidence of residual tumor with a serum Tg below 1 micro g/liter during THST.	Thyrotropin	73-76	thyroglobulin	Homo sapiens	88-90
12679418-9	2003	On the basis of the foregoing, we propose a surveillance guideline using TSH-stimulated Tg levels for patients who have undergone total or near-total thyroidectomy and (131)I ablation for DTC and have no clinical evidence of residual tumor with a serum Tg below 1 micro g/liter during THST.	Thyrotropin	73-76	thyroglobulin	Homo sapiens	253-255
12679418-9	2003	On the basis of the foregoing, we propose a surveillance guideline using TSH-stimulated Tg levels for patients who have undergone total or near-total thyroidectomy and (131)I ablation for DTC and have no clinical evidence of residual tumor with a serum Tg below 1 micro g/liter during THST.	dtc	188-191	thyroglobulin	Homo sapiens	88-90
12679418-9	2003	On the basis of the foregoing, we propose a surveillance guideline using TSH-stimulated Tg levels for patients who have undergone total or near-total thyroidectomy and (131)I ablation for DTC and have no clinical evidence of residual tumor with a serum Tg below 1 micro g/liter during THST.	thst	285-289	thyroglobulin	Homo sapiens	88-90
12444888-1	2002	BACKGROUND: The detection of serum thyroglobulin (Tg) by immunoassay is widely used to detect residual, recurring or metastatic thyroid carcinoma tIssue in patients with differentiated thyroid cancer (DTC) after total thyroidectomy and radioiodine therapy.	Iodine-131	236-247	thyroglobulin	Homo sapiens	35-48
12665314-4	2003	The aim of this study is to evaluate the effectiveness of single photon emission computed tomography (SPECT) with technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI) in detecting metastatic lesions in patients with papillary thyroid carcinoma (PTC) after nearly total thyroidectomy and radioiodine (I-131) treatment who present with elevated serum human thyroglobulin (hTg) levels but negative I-131 whole body scan (WBS).	2-methoxyisobutylisonitrile	129-154	thyroglobulin	Homo sapiens	357-370
12665314-4	2003	The aim of this study is to evaluate the effectiveness of single photon emission computed tomography (SPECT) with technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI) in detecting metastatic lesions in patients with papillary thyroid carcinoma (PTC) after nearly total thyroidectomy and radioiodine (I-131) treatment who present with elevated serum human thyroglobulin (hTg) levels but negative I-131 whole body scan (WBS).	Technetium	156-158	thyroglobulin	Homo sapiens	357-370
12665314-4	2003	The aim of this study is to evaluate the effectiveness of single photon emission computed tomography (SPECT) with technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI) in detecting metastatic lesions in patients with papillary thyroid carcinoma (PTC) after nearly total thyroidectomy and radioiodine (I-131) treatment who present with elevated serum human thyroglobulin (hTg) levels but negative I-131 whole body scan (WBS).	2-methoxyisobutylisonitrile	163-167	thyroglobulin	Homo sapiens	357-370
12399280-8	2002	All measures of iodine intake were significantly related to serum thyroglobulin concentration (P &lt;or= 0.002), but only some measures of iodine intake were significantly related to the prevalence of thyroid nodules.	Iodine	16-22	thyroglobulin	Homo sapiens	66-79
12399280-11	2002	Serum thyroglobulin concentration appears to be a good marker of iodine status.	Iodine	65-71	thyroglobulin	Homo sapiens	6-19
12793603-6	2003	The iodine content in Tg was found to be 0.63 +/- 0.22% in very preterm neonates and was slightly but not significantly lower than that found in the thyroids of the older group (0.82 +/- 0.14%; p = 0.055).	Iodine	4-10	thyroglobulin	Homo sapiens	22-24
12793603-7	2003	The content of T4 and T3 per Tg molecule in the neonates was related to the iodine content.	Iodine	76-82	thyroglobulin	Homo sapiens	29-31
12629092-1	2003	The follow-up of patients with papillary and follicular thyroid carcinoma after thyroidectomy and radioiodine ablation is mainly based on serum thyroglobulin (Tg) level deter-mination.	Iodine-131	98-109	thyroglobulin	Homo sapiens	144-157
12629092-1	2003	The follow-up of patients with papillary and follicular thyroid carcinoma after thyroidectomy and radioiodine ablation is mainly based on serum thyroglobulin (Tg) level deter-mination.	Iodine-131	98-109	thyroglobulin	Homo sapiens	159-161
14530610-5	2003	CONCLUSION: Scintigraphy with [111In]octreotide and 201Tl is an alternative imaging method for the detection of residual disease in patients with a differentiated thyroid carcinoma having increased thyroglobulin levels and a negative radio-iodine total-body scan.	indium-111-octreotide	30-47	thyroglobulin	Homo sapiens	198-211
14530610-5	2003	CONCLUSION: Scintigraphy with [111In]octreotide and 201Tl is an alternative imaging method for the detection of residual disease in patients with a differentiated thyroid carcinoma having increased thyroglobulin levels and a negative radio-iodine total-body scan.	Thallium-201	52-57	thyroglobulin	Homo sapiens	198-211
12444888-1	2002	BACKGROUND: The detection of serum thyroglobulin (Tg) by immunoassay is widely used to detect residual, recurring or metastatic thyroid carcinoma tIssue in patients with differentiated thyroid cancer (DTC) after total thyroidectomy and radioiodine therapy.	Iodine-131	236-247	thyroglobulin	Homo sapiens	50-52
12703121-4	2002	The diagnosis place of radioiodine-131 knew significant changes following the introduction of the serum thyroglobulin measurement.	Iodine-131	23-34	thyroglobulin	Homo sapiens	104-117
12387814-0	2002	The hormonogenic tyrosine 5 of porcine thyroglobulin is sulfated.	Tyrosine	17-25	thyroglobulin	Homo sapiens	39-52
12387814-1	2002	Our previous results showed that sulfated tyrosines of thyroglobulin (Tg), the molecular support of thyroid hormonosynthesis, are involved in the hormonogenic process.	Tyrosine	42-51	thyroglobulin	Homo sapiens	55-68
12387814-1	2002	Our previous results showed that sulfated tyrosines of thyroglobulin (Tg), the molecular support of thyroid hormonosynthesis, are involved in the hormonogenic process.	Tyrosine	42-51	thyroglobulin	Homo sapiens	70-72
12387814-6	2002	Secreted Tg was purified and submitted to peptide sequence analysis which confirmed the known peptide sequence of the NH(2) extremity of Tg:NIFEYQV.	nifeyqv	140-147	thyroglobulin	Homo sapiens	9-11
12387814-6	2002	Secreted Tg was purified and submitted to peptide sequence analysis which confirmed the known peptide sequence of the NH(2) extremity of Tg:NIFEYQV.	nifeyqv	140-147	thyroglobulin	Homo sapiens	137-139
12387814-7	2002	The treatment of [35S]sulfate-labeled Tg by leucine aminopeptidase, which sequentially digested its amino-terminal extremity, released the same amino acids and further analysis by thin layer chromatography showed that the tyrosine was sulfated.	Sulfur-35	18-21	thyroglobulin	Homo sapiens	38-40
12387814-7	2002	The treatment of [35S]sulfate-labeled Tg by leucine aminopeptidase, which sequentially digested its amino-terminal extremity, released the same amino acids and further analysis by thin layer chromatography showed that the tyrosine was sulfated.	Sulfates	22-29	thyroglobulin	Homo sapiens	38-40
12387814-7	2002	The treatment of [35S]sulfate-labeled Tg by leucine aminopeptidase, which sequentially digested its amino-terminal extremity, released the same amino acids and further analysis by thin layer chromatography showed that the tyrosine was sulfated.	Tyrosine	222-230	thyroglobulin	Homo sapiens	38-40
12402382-4	2002	Six months later, a follow-up I(131) whole body scan showed continued radioactive iodine uptake in the retrosternal area and the serum thyroglobulin level remained continuously elevated with levothyroxine suppression therapy (22.3 and 36.4 ng/ml, 6 and 10 months after total thyroidectomy, respectively).	Thyroxine	191-204	thyroglobulin	Homo sapiens	135-148
12097194-17	2002	Using an ELISA approach, we found that Tg in OT from three TAO patients (P10, P11, and P12) contained thyroxine (T4) residues (mean T(4) CONTENT: 2.42 molecules per molecule of Tg), indicating that Tg had originated in the thyroid.	Thyroxine	102-111	thyroglobulin	Homo sapiens	39-41
12029550-5	2002	The thyroglobulin level was measured both during TSH-suppressive L-thyroxine therapy (Tg-on) and 4-6 weeks after L-thyroxine withdrawal (Tg-off, TSH&gt;20 mU/l).	Thyroxine	65-76	thyroglobulin	Homo sapiens	4-17
12029550-5	2002	The thyroglobulin level was measured both during TSH-suppressive L-thyroxine therapy (Tg-on) and 4-6 weeks after L-thyroxine withdrawal (Tg-off, TSH&gt;20 mU/l).	Thioguanine	86-88	thyroglobulin	Homo sapiens	4-17
12029550-5	2002	The thyroglobulin level was measured both during TSH-suppressive L-thyroxine therapy (Tg-on) and 4-6 weeks after L-thyroxine withdrawal (Tg-off, TSH&gt;20 mU/l).	Thyroxine	113-124	thyroglobulin	Homo sapiens	4-17
12029550-5	2002	The thyroglobulin level was measured both during TSH-suppressive L-thyroxine therapy (Tg-on) and 4-6 weeks after L-thyroxine withdrawal (Tg-off, TSH&gt;20 mU/l).	Thioguanine	137-139	thyroglobulin	Homo sapiens	4-17
12100079-2	2002	OBJECTIVE: We therefore analysed retrospectively the effects of radioiodine therapy on the course of serum thyroglobulin levels as a tumour marker in patients with progressive residual or metastatic differentiated thyroid carcinoma, with or without radioiodine accumulation on post-therapeutic whole body scintigraphy.	Iodine-131	64-75	thyroglobulin	Homo sapiens	107-120
12100079-10	2002	Absolute serum thyroglobulin levels and radiological follow-up revealed a favourable response of radioiodine therapy in the positive whole body scintigraphy group but not in the negative group.	Iodine-131	97-108	thyroglobulin	Homo sapiens	15-28
12193302-10	2002	In conclusion, these data suggest rhTSH-stimulated Tg testing without scan may be a useful tool in the follow-up of patients with low-risk thyroid cancer, and may serve to identify patients previously thought free of disease on the basis of undetectable Tg levels while undergoing THST.	thst	281-285	thyroglobulin	Homo sapiens	51-53
12097194-18	2002	Combining the results obtained in our previous and present study, we found a possible relation between the presence of Tg in OT and the previous treatment with radioiodine.	Iodine-131	160-171	thyroglobulin	Homo sapiens	119-121
12097194-22	2002	There was a relation between the presence of Tg in OT and the previous treatment with radioiodine.	Iodine-131	86-97	thyroglobulin	Homo sapiens	45-47
11863477-8	2002	RESULTS: Serum thyroglobulin level and thyroid volume at ultrasonography were positively associated with smoking habits (P&lt;.001); the association was stronger in the area with the lowest iodine intake (interaction: P&lt;.001 for thyroglobulin, P =.04 for thyroid volume).	Iodine	190-196	thyroglobulin	Homo sapiens	15-28
11916630-0	2002	Binding of heparin to human thyroglobulin (Tg) involves multiple binding sites including a region corresponding to a binding site of rat Tg.	Heparin	11-18	thyroglobulin	Homo sapiens	28-41
11916630-1	2002	OBJECTIVE: Binding of thyroglobulin (Tg) to heparin allows efficient Tg interaction with its endocytic receptor, megalin.	Heparin	44-51	thyroglobulin	Homo sapiens	22-35
11736644-0	2001	Hydrogen peroxide-induced production of a 40 kDa immunoreactive thyroglobulin fragment in human thyroid cells: the onset of thyroid autoimmunity?	Hydrogen Peroxide	0-17	thyroglobulin	Homo sapiens	64-77
12635359-6	2002	It was suggested that iodine increase the autoantigenic potency of thyroglobulin, a major pathogenic antigen in the induction of autoimmune thyroiditis.	Iodine	22-28	thyroglobulin	Homo sapiens	67-80
11736644-4	2001	In culture conditions allowing Tg synthesis and iodine organification by the cells, we found that bolus addition of increasing millimolar doses of H(2)O(2) induced a dose-response appearance of floating cells in the culture medium.	Hydrogen Peroxide	147-155	thyroglobulin	Homo sapiens	31-33
11694378-4	2001	Moreover, changes in morphological characteristics and production of Tg, T3 and T4 induced by addition of thyroid stimulating hormone (TSH) and epidermal growth factor (EGF) to medium in collagen gel culture were determined.	Thyrotropin	106-133	thyroglobulin	Homo sapiens	69-71
11505212-11	2001	Serum Tgb levels were under 10 ng.ml(-1) in 220 of the 242 patients (90%) following radioiodine ablation while not receiving L-thyroxine suppression.	Iodine-131	84-95	thyroglobulin	Homo sapiens	6-9
11488894-8	2001	Thirteen percent of men taking CBZ, 17% of men taking OCBZ, and 6% of control men had increased levels of thyroid peroxidase (TPO)-ab and/or thyroglobulin (TG)-ab, but these were not associated with altered serum thyroid hormone concentrations.	Carbamazepine	31-34	thyroglobulin	Homo sapiens	141-154
11488894-8	2001	Thirteen percent of men taking CBZ, 17% of men taking OCBZ, and 6% of control men had increased levels of thyroid peroxidase (TPO)-ab and/or thyroglobulin (TG)-ab, but these were not associated with altered serum thyroid hormone concentrations.	Oxcarbazepine	54-58	thyroglobulin	Homo sapiens	141-154
11517924-3	2001	The cysteine proteinases mediate the processing of thyroglobulin by limited extracellular proteolysis at the apical plasma membrane, thereby rapidly liberating thyroxine.	Thyroxine	160-169	thyroglobulin	Homo sapiens	51-64
11431154-3	2001	To identify the regions of Tg involved in this cell surface binding, we studied the binding of (125)I-labeled cyanogen bromide peptides from human Tg to cell surfaces of thyroid cells (inside-out follicles) and of CHO cells.	cyanogen bromide peptides	110-135	thyroglobulin	Homo sapiens	147-149
11517924-5	2001	We propose that thyroid stimulating hormone regulates extracellular proteolysis of thyroglobulin in that it enhances the rate of exocytosis of lysosomal proteins at the apical plasma membrane.	Thyrotropin	16-43	thyroglobulin	Homo sapiens	83-96
11396699-3	2001	Further action of TPO, hydrogen peroxide (H2O2), and iodinated Tg produce thyroxine (T4) and triiodothyronine (T3).	Thyroxine	74-83	thyroglobulin	Homo sapiens	63-65
11396699-3	2001	Further action of TPO, hydrogen peroxide (H2O2), and iodinated Tg produce thyroxine (T4) and triiodothyronine (T3).	Triiodothyronine	93-109	thyroglobulin	Homo sapiens	63-65
11396699-1	2001	The thyroid concentrates iodide from the serum and oxidizes it at the apical membrane, attaching it to tyrosyl residues within thyroglobulin (Tg) to make diiodotyrosine and monoiodotyrosine.	Iodides	25-31	thyroglobulin	Homo sapiens	127-140
11396699-3	2001	Further action of TPO, hydrogen peroxide (H2O2), and iodinated Tg produce thyroxine (T4) and triiodothyronine (T3).	Triiodothyronine	111-113	thyroglobulin	Homo sapiens	63-65
11396699-1	2001	The thyroid concentrates iodide from the serum and oxidizes it at the apical membrane, attaching it to tyrosyl residues within thyroglobulin (Tg) to make diiodotyrosine and monoiodotyrosine.	Iodides	25-31	thyroglobulin	Homo sapiens	142-144
11396701-11	2001	By contrast, in the central phase, iodine has direct effects on thymus development, the development and function of various immune cells (T cells, B cells macrophages and dendritic cells) and the antigenicity of thyroglobulin.	Iodine	35-41	thyroglobulin	Homo sapiens	212-225
11396699-1	2001	The thyroid concentrates iodide from the serum and oxidizes it at the apical membrane, attaching it to tyrosyl residues within thyroglobulin (Tg) to make diiodotyrosine and monoiodotyrosine.	cyclo(tyrosyl-tyrosyl)	103-110	thyroglobulin	Homo sapiens	127-140
11396699-1	2001	The thyroid concentrates iodide from the serum and oxidizes it at the apical membrane, attaching it to tyrosyl residues within thyroglobulin (Tg) to make diiodotyrosine and monoiodotyrosine.	cyclo(tyrosyl-tyrosyl)	103-110	thyroglobulin	Homo sapiens	142-144
11303631-13	2001	This study suggests that distant metastasis may occur at a serum Tg level of 2.3 ng/mL with thyroxine replacement.	Thyroxine	92-101	thyroglobulin	Homo sapiens	65-67
11396699-1	2001	The thyroid concentrates iodide from the serum and oxidizes it at the apical membrane, attaching it to tyrosyl residues within thyroglobulin (Tg) to make diiodotyrosine and monoiodotyrosine.	Diiodotyrosine	154-168	thyroglobulin	Homo sapiens	127-140
11396699-1	2001	The thyroid concentrates iodide from the serum and oxidizes it at the apical membrane, attaching it to tyrosyl residues within thyroglobulin (Tg) to make diiodotyrosine and monoiodotyrosine.	Diiodotyrosine	154-168	thyroglobulin	Homo sapiens	142-144
11396699-1	2001	The thyroid concentrates iodide from the serum and oxidizes it at the apical membrane, attaching it to tyrosyl residues within thyroglobulin (Tg) to make diiodotyrosine and monoiodotyrosine.	Monoiodotyrosine	173-189	thyroglobulin	Homo sapiens	127-140
11396699-1	2001	The thyroid concentrates iodide from the serum and oxidizes it at the apical membrane, attaching it to tyrosyl residues within thyroglobulin (Tg) to make diiodotyrosine and monoiodotyrosine.	Monoiodotyrosine	173-189	thyroglobulin	Homo sapiens	142-144
11303890-0	2001	Efficacy of high therapeutic doses of iodine-131 in patients with differentiated thyroid cancer and detectable serum thyroglobulin.	Iodine-131	38-48	thyroglobulin	Homo sapiens	117-130
11303890-2	2001	We evaluated the effect of so-called blind therapeutic doses of iodine-131 in patients with detectable Tg during suppressive levothyroxine treatment (Tg-on), and in patients with a negative diagnostic scintigram but detectable Tg during the hypothyroid phase (Tg-off).	Iodine-131	64-74	thyroglobulin	Homo sapiens	103-105
11158019-5	2001	Two hundred and eighty-nine patients were examined by both DxWBS and by measurement of the serum thyroglobulin (Tg) response to elevated TSH levels.	Thyrotropin	137-140	thyroglobulin	Homo sapiens	97-110
11158054-6	2001	In experiments in which the herpes simplex virus thymidine kinase (HSV-TK) gene was driven by the Tg promoter and the putative enhancer, HSV-TK expression and ganciclovir sensitivity were augmented.	Ganciclovir	159-170	thyroglobulin	Homo sapiens	98-100
11158019-5	2001	Two hundred and eighty-nine patients were examined by both DxWBS and by measurement of the serum thyroglobulin (Tg) response to elevated TSH levels.	Thyrotropin	137-140	thyroglobulin	Homo sapiens	112-114
11272097-7	2001	Tg endocytosis via megalin is facilitated by the interaction of Tg with cell surface heparan sulfate proteoglycans, which occurs via a carboxyl terminal heparin binding site of Tg functionally related with a major megalin binding site.	Heparin	153-160	thyroglobulin	Homo sapiens	0-2
11137035-0	2001	Effects of thyroglobulin and pendrin on iodide flux through the thyrocyte.	Iodides	40-46	thyroglobulin	Homo sapiens	11-24
11137035-3	2001	For example, whereas follicular thyroglobulin suppresses the gene expression and activity of the sodium iodide symporter (NIS), it increases pendrin gene expression.	Sodium Iodide	97-110	thyroglobulin	Homo sapiens	32-45
11137035-3	2001	For example, whereas follicular thyroglobulin suppresses the gene expression and activity of the sodium iodide symporter (NIS), it increases pendrin gene expression.	Nickel	122-125	thyroglobulin	Homo sapiens	32-45
11288978-3	2001	TSH dose-dependently increased T3 and Tg but not IL-6 levels in the conditioned medium.	Thyrotropin	0-3	thyroglobulin	Homo sapiens	38-40
11272097-7	2001	Tg endocytosis via megalin is facilitated by the interaction of Tg with cell surface heparan sulfate proteoglycans, which occurs via a carboxyl terminal heparin binding site of Tg functionally related with a major megalin binding site.	Heparin	153-160	thyroglobulin	Homo sapiens	64-66
11272097-7	2001	Tg endocytosis via megalin is facilitated by the interaction of Tg with cell surface heparan sulfate proteoglycans, which occurs via a carboxyl terminal heparin binding site of Tg functionally related with a major megalin binding site.	Heparin	153-160	thyroglobulin	Homo sapiens	64-66
11213579-1	2000	OBJECTIVES: The objective of this work has been to know the sensitivity of serum thyroglobulin and I-131 scintigraphy in the detection of thyroid remnants or metastases, and to evaluate the predictive value of serum thyroglobulin in the follow-up of differentiated thyroid cancer patients.	thyroid remnants	138-154	thyroglobulin	Homo sapiens	81-94
11669557-1	2001	The aim of this case-control study was to determine the utility of the evaluation of changes in serum thyroglobulin (Tg) levels before and after 1311 diagnostic total body scan (TBS) in patients with thyroid cancer to predict the efficacy of radioiodine ablation.	Iodine-131	242-253	thyroglobulin	Homo sapiens	102-115
11669557-1	2001	The aim of this case-control study was to determine the utility of the evaluation of changes in serum thyroglobulin (Tg) levels before and after 1311 diagnostic total body scan (TBS) in patients with thyroid cancer to predict the efficacy of radioiodine ablation.	Iodine-131	242-253	thyroglobulin	Homo sapiens	117-119
11669557-10	2001	This study supports the concept that by monitoring Tg levels in patients who undergo diagnostic TBS before radioiodine ablation it is possible to obtain useful information about the efficacy of 131I therapy.	Iodine-131	107-118	thyroglobulin	Homo sapiens	51-53
11669557-10	2001	This study supports the concept that by monitoring Tg levels in patients who undergo diagnostic TBS before radioiodine ablation it is possible to obtain useful information about the efficacy of 131I therapy.	Iodine-131	194-198	thyroglobulin	Homo sapiens	51-53
11078701-0	2000	15-Deoxy-Delta(12,14)-prostaglandin J(2) facilitates thyroglobulin production by cultured human thyrocytes.	15-deoxy-delta(12,14)-prostaglandin j	0-37	thyroglobulin	Homo sapiens	53-66
12182045-0	2001	[Prospective analysis of criteria for interpreting measurements of thyroglobulin serum concentration during conditions of endogenous TSH stimulation in serum of patients with differentiated thyroid carcinoma].	Thyrotropin	133-136	thyroglobulin	Homo sapiens	67-80
12182045-1	2001	The aim of this study was the assessment of diagnostic value of thyroglobulin serum measurement in patients with DTC during endogenous TSH stimulation.	Ditiocarb	113-116	thyroglobulin	Homo sapiens	64-77
12182045-1	2001	The aim of this study was the assessment of diagnostic value of thyroglobulin serum measurement in patients with DTC during endogenous TSH stimulation.	Thyrotropin	135-138	thyroglobulin	Homo sapiens	64-77
12182046-3	2001	All serum thyroglobulin assays can be falsified by presence of Tg autoantibodies, which are present in approximately 20% of DTC patients.	dtc	124-127	thyroglobulin	Homo sapiens	10-23
11193452-8	2000	The effect of 131I treatment was evaluated by means of changes in the number and size of metastatic shadows on chest CT and by serum thyroglobulin levels.	Iodine-131	14-18	thyroglobulin	Homo sapiens	133-146
11205668-7	2000	Increased thyroglobulin level led to 131I scanning, which showed focal retropharyngeal uptake.	Iodine-131	37-41	thyroglobulin	Homo sapiens	10-23
11155095-12	2000	Fourteen women with excessive thyroidal stimulation in the second trimester (defined as those with thyroglobulin (Tg) concentrations in the highest tertile and FTI in the lowest tertile) were found to have lower urine iodine concentrations and larger TV (both P &lt; 0.005) throughout pregnancy, and their neonates had higher cord TSH (P &lt; 0.05), Tg (P &lt; 0.05) and slightly larger TV (P = 0.06) as compared to the findings in 216 pregnant women without evidence of thyroid stimulation.	Iodine	218-224	thyroglobulin	Homo sapiens	114-116
10876005-0	2000	A new assay for thyroglobulin concentration in serum using monoclonal antibodies against synthetic peptides.	Peptides	99-107	thyroglobulin	Homo sapiens	16-29
11022845-0	2000	Cu2+-catalyzed oxidative degradation of thyroglobulin.	cupric ion	0-4	thyroglobulin	Homo sapiens	40-53
11022845-1	2000	Thyroglobulin (Tg) was subjected to metal-catalyzed oxidation, and the oxidative degradation was analyzed by SDS-polyacrylamide gel electrophoresis under reducing conditions.	Metals	36-41	thyroglobulin	Homo sapiens	0-13
11022845-1	2000	Thyroglobulin (Tg) was subjected to metal-catalyzed oxidation, and the oxidative degradation was analyzed by SDS-polyacrylamide gel electrophoresis under reducing conditions.	Metals	36-41	thyroglobulin	Homo sapiens	15-17
11022845-1	2000	Thyroglobulin (Tg) was subjected to metal-catalyzed oxidation, and the oxidative degradation was analyzed by SDS-polyacrylamide gel electrophoresis under reducing conditions.	Sodium Dodecyl Sulfate	109-112	thyroglobulin	Homo sapiens	0-13
11022845-1	2000	Thyroglobulin (Tg) was subjected to metal-catalyzed oxidation, and the oxidative degradation was analyzed by SDS-polyacrylamide gel electrophoresis under reducing conditions.	Sodium Dodecyl Sulfate	109-112	thyroglobulin	Homo sapiens	15-17
11022845-1	2000	Thyroglobulin (Tg) was subjected to metal-catalyzed oxidation, and the oxidative degradation was analyzed by SDS-polyacrylamide gel electrophoresis under reducing conditions.	polyacrylamide	113-127	thyroglobulin	Homo sapiens	0-13
11022845-1	2000	Thyroglobulin (Tg) was subjected to metal-catalyzed oxidation, and the oxidative degradation was analyzed by SDS-polyacrylamide gel electrophoresis under reducing conditions.	polyacrylamide	113-127	thyroglobulin	Homo sapiens	15-17
11022845-2	2000	In contrast to no effect of hydrogen peroxide (H2O2) alone on the Tg degradation, the inclusion of Cu2+ (30 microM), in combination with 2 mM H2O2, caused a remarkable degradation of Tg, time- and concentration-dependent.	cupric ion	99-103	thyroglobulin	Homo sapiens	66-68
11022845-2	2000	In contrast to no effect of hydrogen peroxide (H2O2) alone on the Tg degradation, the inclusion of Cu2+ (30 microM), in combination with 2 mM H2O2, caused a remarkable degradation of Tg, time- and concentration-dependent.	cupric ion	99-103	thyroglobulin	Homo sapiens	183-185
11022845-2	2000	In contrast to no effect of hydrogen peroxide (H2O2) alone on the Tg degradation, the inclusion of Cu2+ (30 microM), in combination with 2 mM H2O2, caused a remarkable degradation of Tg, time- and concentration-dependent.	Hydrogen Peroxide	142-146	thyroglobulin	Homo sapiens	183-185
11022845-3	2000	The action of Cu2+ was not mimicked by Fe2+, suggesting that Tg may interact selectively with Cu2+.	cupric ion	14-18	thyroglobulin	Homo sapiens	61-63
11022845-3	2000	The action of Cu2+ was not mimicked by Fe2+, suggesting that Tg may interact selectively with Cu2+.	cupric ion	94-98	thyroglobulin	Homo sapiens	61-63
11022845-4	2000	A similar degradation of Tg was also observed with Cu2+/ascorbate system, and the concentration of Cu2+ (5-10 microM), in combination with ascorbate, required for the effective degradation was smaller than that of Cu2+ (10-30 microM) in combination with H2O2.	cupric ion	51-55	thyroglobulin	Homo sapiens	25-27
11022845-4	2000	A similar degradation of Tg was also observed with Cu2+/ascorbate system, and the concentration of Cu2+ (5-10 microM), in combination with ascorbate, required for the effective degradation was smaller than that of Cu2+ (10-30 microM) in combination with H2O2.	Ascorbic Acid	56-65	thyroglobulin	Homo sapiens	25-27
11022845-4	2000	A similar degradation of Tg was also observed with Cu2+/ascorbate system, and the concentration of Cu2+ (5-10 microM), in combination with ascorbate, required for the effective degradation was smaller than that of Cu2+ (10-30 microM) in combination with H2O2.	cupric ion	99-103	thyroglobulin	Homo sapiens	25-27
11022845-4	2000	A similar degradation of Tg was also observed with Cu2+/ascorbate system, and the concentration of Cu2+ (5-10 microM), in combination with ascorbate, required for the effective degradation was smaller than that of Cu2+ (10-30 microM) in combination with H2O2.	Ascorbic Acid	139-148	thyroglobulin	Homo sapiens	25-27
11022845-4	2000	A similar degradation of Tg was also observed with Cu2+/ascorbate system, and the concentration of Cu2+ (5-10 microM), in combination with ascorbate, required for the effective degradation was smaller than that of Cu2+ (10-30 microM) in combination with H2O2.	cupric ion	99-103	thyroglobulin	Homo sapiens	25-27
11022845-4	2000	A similar degradation of Tg was also observed with Cu2+/ascorbate system, and the concentration of Cu2+ (5-10 microM), in combination with ascorbate, required for the effective degradation was smaller than that of Cu2+ (10-30 microM) in combination with H2O2.	Hydrogen Peroxide	254-258	thyroglobulin	Homo sapiens	25-27
11022845-7	2000	Moreover, the amount of carbonyl groups in Tg was increased as the concentration (3-100 microM) of Cu2+ was enhanced, while the formation of acid-soluble peptides was not remarkable in the presence of Cu2+ up to 200 microM.	cupric ion	99-103	thyroglobulin	Homo sapiens	43-45
11022845-8	2000	In further studies, Tg pretreated with heat or trichloroacetic acid seemed to be somewhat resistant to Cu2+-catalyzed oxidation, implying a possible involvement of protein conformation in the susceptibility to the oxidation.	Trichloroacetic Acid	47-67	thyroglobulin	Homo sapiens	20-22
11022845-8	2000	In further studies, Tg pretreated with heat or trichloroacetic acid seemed to be somewhat resistant to Cu2+-catalyzed oxidation, implying a possible involvement of protein conformation in the susceptibility to the oxidation.	cupric ion	103-107	thyroglobulin	Homo sapiens	20-22
11022845-9	2000	Based on these observations, it is proposed that Tg could be degraded non-enzymatically by Cu2+-catalyzed oxidation.	cupric ion	91-95	thyroglobulin	Homo sapiens	49-51
11141594-4	2000	Currently, use of radioiodine for ablation has been shown to decrease the risk of recurrence, increase the sensitivity of postablation whole-body scanning with radioiodine, and increase the sensitivity of serum thyroglobulin testing.	Iodine-131	18-29	thyroglobulin	Homo sapiens	211-224
11141594-11	2000	Therapeutic radioiodine is being given to patients with detectable thyroglobulin but negative (131)I whole-body scans with increasing frequency.	Iodine-131	12-23	thyroglobulin	Homo sapiens	67-80
10987366-0	2000	The thioredoxin boxes of thyroglobulin: possible implications for intermolecular disulfide bond formation in the follicle lumen.	Disulfides	81-90	thyroglobulin	Homo sapiens	25-38
10938686-4	2000	Two years after subtotal thyroidectomy and an ablative dose of iodine 131, the whole body scan showed abdominal mediastinal uptake with low serum thyroglobulin level.	Iodine	63-69	thyroglobulin	Homo sapiens	146-159
10987366-2	2000	Human thyroglobulin (hTG) has been shown to multimerize mainly by intermolecular disulfide cross-links.	Disulfides	81-90	thyroglobulin	Homo sapiens	6-19
10911555-3	2000	Thyroglobulin levels were increased in 5 subjects only, all with reduced iodine excretion.	Iodine	73-79	thyroglobulin	Homo sapiens	0-13
10792347-2	2000	The aim of this study is to evaluate the effect of embolization with concomitant radioiodine treatment on the serum thyroglobulin (Tg) level, pain and neurological symptoms in patients with large bone metastases from differentiated thyroid carcinoma.	Iodine-131	81-92	thyroglobulin	Homo sapiens	116-129
10792347-2	2000	The aim of this study is to evaluate the effect of embolization with concomitant radioiodine treatment on the serum thyroglobulin (Tg) level, pain and neurological symptoms in patients with large bone metastases from differentiated thyroid carcinoma.	Iodine-131	81-92	thyroglobulin	Homo sapiens	131-133
10792347-11	2000	CONCLUSIONS: This preliminary study suggests that embolization of bone metastases of differentiated thyroid carcinoma in combination with radioiodine treatment results in a significant initial reduction of serum Tg level compared to radioiodine treatment alone.	Iodine-131	138-149	thyroglobulin	Homo sapiens	212-214
10792347-11	2000	CONCLUSIONS: This preliminary study suggests that embolization of bone metastases of differentiated thyroid carcinoma in combination with radioiodine treatment results in a significant initial reduction of serum Tg level compared to radioiodine treatment alone.	Iodine-131	233-244	thyroglobulin	Homo sapiens	212-214
10875253-1	2000	Here, we studied the fragmentation of the prothyroid hormone, thyroglobulin (Tg), which occurs during thyroid hormone synthesis, a process which involves iodide, thyroperoxidase, and the H2O2-generating system, consisting of glucose and glucose oxidase.	Iodides	154-160	thyroglobulin	Homo sapiens	62-75
10875253-1	2000	Here, we studied the fragmentation of the prothyroid hormone, thyroglobulin (Tg), which occurs during thyroid hormone synthesis, a process which involves iodide, thyroperoxidase, and the H2O2-generating system, consisting of glucose and glucose oxidase.	Hydrogen Peroxide	187-191	thyroglobulin	Homo sapiens	62-75
10875253-1	2000	Here, we studied the fragmentation of the prothyroid hormone, thyroglobulin (Tg), which occurs during thyroid hormone synthesis, a process which involves iodide, thyroperoxidase, and the H2O2-generating system, consisting of glucose and glucose oxidase.	Glucose	225-232	thyroglobulin	Homo sapiens	62-75
11370541-4	2000	Thyroglobulin, being organ-specific, plays a major role as tumor marker and it is used essentially in the monitoring and follow-up of patients with differentiated thyroid carcinoma, both during L-thyroxine suppressive therapy and when it is discontinued or after recombinant TSH administration.	Thyroxine	194-205	thyroglobulin	Homo sapiens	0-13
11370541-4	2000	Thyroglobulin, being organ-specific, plays a major role as tumor marker and it is used essentially in the monitoring and follow-up of patients with differentiated thyroid carcinoma, both during L-thyroxine suppressive therapy and when it is discontinued or after recombinant TSH administration.	Thyrotropin	275-278	thyroglobulin	Homo sapiens	0-13
10787191-0	2000	Treating the patient with differentiated thyroid cancer with thyroglobulin-positive iodine-131 diagnostic scan-negative metastases: including comments on the role of serum thyroglobulin monitoring in tumor surveillance.	Iodine	84-90	thyroglobulin	Homo sapiens	61-74
10690866-9	2000	The association between iodine supplementation and high serum TSH in the neonates was further substantiated by an inverse correlation between thyroglobulin and TSH in cord blood (P &lt; 0.001), whereas no specific pattern was observed in the mothers.	Iodine	24-30	thyroglobulin	Homo sapiens	142-155
10783567-7	2000	Serum thyroglobulin (Tg) was significantly higher in 201Tl and/or 99mTc-MIBI positive group compared to that of negative group independent of 131I scan results.	2-methoxyisobutylisonitrile	71-76	thyroglobulin	Homo sapiens	6-19
10783567-7	2000	Serum thyroglobulin (Tg) was significantly higher in 201Tl and/or 99mTc-MIBI positive group compared to that of negative group independent of 131I scan results.	Iodine-131	142-146	thyroglobulin	Homo sapiens	6-19
10768565-9	2000	When Tg levels were high (&gt;10 pmol/L), local recurrence or metastases were always observed, providing the basis for additional high-dose 131I therapy.	Iodine-131	140-144	thyroglobulin	Homo sapiens	5-7
10690866-9	2000	The association between iodine supplementation and high serum TSH in the neonates was further substantiated by an inverse correlation between thyroglobulin and TSH in cord blood (P &lt; 0.001), whereas no specific pattern was observed in the mothers.	Thyrotropin	62-65	thyroglobulin	Homo sapiens	142-155
10690866-10	2000	High serum thyroglobulin was a marker of low iodine intake in both mothers and neonates.	Iodine	45-51	thyroglobulin	Homo sapiens	11-24
10718554-0	2000	Serum thyroglobulin levels after thyroxine withdrawal in patients with low risk papillary thyroid carcinoma.	Thyroxine	33-42	thyroglobulin	Homo sapiens	6-19
10718554-3	2000	Of the 35 patients who manifested a low-risk carcinoma, 9 (26%) exhibited elevated Tg concentrations (11-53 ng/mL) during thyroxine withdrawal after therapies, while clinical, scintigraphic, and radiographic studies at least 1 year later showed no evidence of tumor.	Thyroxine	122-131	thyroglobulin	Homo sapiens	83-85
10634383-11	2000	A 131I-TBS performed with 3.7 GBq in nine patients with a Tg level above 10 ng/mL, showed foci of uptake outside the thyroid bed in three patients; lung metastases were demonstrated by a CT scan in another patient, and palpable lymph node metastases were found in one patient.	131i-tbs	2-10	thyroglobulin	Homo sapiens	58-60
10757448-0	2000	Thyroglobulin in serum as an indicator of iodine status during pregnancy.	Iodine	42-48	thyroglobulin	Homo sapiens	0-13
10757448-12	2000	A significantly negative correlation was shown between serum thyroglobulin and urinary iodine concentrations during the second and third trimesters in the Swedish women (r= -0.8, p=0.01 and r= -0.5, p=0.03, respectively), and in the third trimester in the Sudanese women (r= -0.6, p=0.03).	Iodine	87-93	thyroglobulin	Homo sapiens	61-74
10757448-14	2000	It is concluded that serum thyroglobulin is a more sensitive indicator of iodine deficiency than serum thyrotropin during pregnancy.	Iodine	74-80	thyroglobulin	Homo sapiens	27-40
10826964-10	2000	Iodine plays an important role in the precise specificity of the disease-associated epitope, since T cells from patients with thyroiditis react with iodinated but not noniodinated human thyroglobulin.	Iodine	0-6	thyroglobulin	Homo sapiens	186-199
10634383-13	2000	The serum Tg level obtained after withdrawal of T4 treatment permits the selection of patients with a Tg level exceeding 10 ng/mL, for scanning with 3.7 GBq (100 mCi).	GBQ	153-156	thyroglobulin	Homo sapiens	10-12
10566646-13	1999	Eight of the nine patients studied with low and high TSH concentrations displayed greater amounts of circulating Tg mRNA after T4 withdrawal.	Thyrotropin	53-56	thyroglobulin	Homo sapiens	113-115
10566623-2	1999	The objectives of this study were to compare the effect of administered recombinant human TSH with thyroid hormone withdrawal on the results of radioiodine whole body scanning (WBS) and serum thyroglobulin (Tg) levels.	Thyrotropin	90-93	thyroglobulin	Homo sapiens	192-205
10566623-9	1999	In conclusion, recombinant human TSH administration is a safe and effective means of stimulating radioiodine uptake and serum Tg levels in patients undergoing evaluation for thyroid cancer persistence and recurrence.	Thyrotropin	33-36	thyroglobulin	Homo sapiens	126-128
10599717-0	1999	Levothyroxine suppression of thyroglobulin in patients with differentiated thyroid carcinoma.	Thyroxine	0-13	thyroglobulin	Homo sapiens	29-42
10700830-2	1999	Repeated 131I treatment effectively reduced serum thyroglobulin (Tg) level and tumour uptake of 131I, despite absence of any change in size of the treated tumour.	Iodine-131	9-13	thyroglobulin	Homo sapiens	50-63
10700830-2	1999	Repeated 131I treatment effectively reduced serum thyroglobulin (Tg) level and tumour uptake of 131I, despite absence of any change in size of the treated tumour.	Iodine-131	9-13	thyroglobulin	Homo sapiens	65-67
10537174-0	1999	Follicular thyroglobulin suppresses iodide uptake by suppressing expression of the sodium/iodide symporter gene.	Iodides	36-42	thyroglobulin	Homo sapiens	11-24
10537174-0	1999	Follicular thyroglobulin suppresses iodide uptake by suppressing expression of the sodium/iodide symporter gene.	Iodides	90-96	thyroglobulin	Homo sapiens	11-24
10524569-10	1999	The three tyrosine residues involved in thyroid hormones synthesis (amino acids 2554, 2568, and 2747) at the carbosyl termini of Tg, are encoded by exons 44, 45, and 48.	Tyrosine	10-18	thyroglobulin	Homo sapiens	129-131
10482377-3	1999	The present study was carried out to determine whether the oral administration of human thyroglobulin (hTg) would decrease the incidence of spontaneous and iodine-induced LT in the BB/Wor rat.	Iodine	156-162	thyroglobulin	Homo sapiens	88-101
10448091-0	1999	Sulfated tyrosines of thyroglobulin are involved in thyroid hormone synthesis.	Tyrosine	9-18	thyroglobulin	Homo sapiens	22-35
10448091-1	1999	Thyroid hormone synthesis is under the control of thyrotropin (TSH), which also regulates the sulfation of tyrosines in thyroglobulin (Tg).	Tyrosine	107-116	thyroglobulin	Homo sapiens	120-133
10439182-1	1999	Whole-body 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) positron emission tomography (PET) of a 54-year-old woman with a history of recurrent thyroid follicular cancer and an elevated thyroglobulin level showed significant FDG uptake in the thyroid bed and anterior mediastinum.	2-deoxy-2-[f-18]fluoro-d-glucose	11-43	thyroglobulin	Homo sapiens	178-191
10418587-14	1999	Serum thyroglobulin levels are most precise when patients are hypothyroid (high TSH) and may be unreliable in patients with antithyroglobulin antibodies.	Thyrotropin	80-83	thyroglobulin	Homo sapiens	6-19
10404792-0	1999	[18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography localizes residual thyroid cancer in patients with negative diagnostic (131)I whole body scans and elevated serum thyroglobulin levels.	Fluorodeoxyglucose F18	6-32	thyroglobulin	Homo sapiens	176-189
10404792-2	1999	We tested the hypothesis that all metastatic thyroid cancer lesions that did not concentrate iodine, but did produce thyroglobulin (Tg), could be localized by [18F]2-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET).	Fluorodeoxyglucose F18	164-190	thyroglobulin	Homo sapiens	117-130
10418587-2	1999	The purpose of this investigation was to determine the accuracy of serum thyroglobulin levels in predicting persistent or recurrent DTC in euthyroid and hypothyroid patients.	Ditiocarb	132-135	thyroglobulin	Homo sapiens	73-86
10418587-15	1999	We recommend TSH-stimulated thyroglobulin testing for all patients after total thyroidectomy for differentiated thyroid cancer of follicular cell origin regardless of patient age or risk group.	Thyrotropin	13-16	thyroglobulin	Homo sapiens	28-41
10418587-4	1999	One hundred fifteen patients had serum thyroglobulin levels measured when hypothyroid for radioiodine scanning or ablation.	Iodine-131	90-101	thyroglobulin	Homo sapiens	39-52
10403182-9	1999	Sequential iodination of low iodine human Tg shows three consensus sequences associated with early iodination and with T4 formation.	Iodine	29-35	thyroglobulin	Homo sapiens	42-44
10351986-5	1999	RT-PCR using intron-spanning primers was used to quantitatively amplify thyroglobulin mRNA, using the ABI PRISM 7700 Sequence Detection System with a fluorescent-labeled, thyroglobulin-specific oligonucleotide probe.	Oligonucleotides	194-209	thyroglobulin	Homo sapiens	72-85
10351986-5	1999	RT-PCR using intron-spanning primers was used to quantitatively amplify thyroglobulin mRNA, using the ABI PRISM 7700 Sequence Detection System with a fluorescent-labeled, thyroglobulin-specific oligonucleotide probe.	Oligonucleotides	194-209	thyroglobulin	Homo sapiens	171-184
10403191-4	1999	Thyroid weight and sialic acid content of thyroglobulin progressed with maturation.	N-Acetylneuraminic Acid	19-30	thyroglobulin	Homo sapiens	42-55
10403191-7	1999	T4 and T3 content of thyroglobulin was directly proportional to its degree of iodination and positively related to its sialic acid content.	N-Acetylneuraminic Acid	119-130	thyroglobulin	Homo sapiens	21-34
10403182-10	1999	Recent work has identified Tyr130 in beef Tg as donor of an outer iodothyronine ring, most likely to Tyr5, the most important hormonogenic site.	iodothyronine	66-79	thyroglobulin	Homo sapiens	42-44
10403189-7	1999	Since additional carbohydrate groups are added to the immature thyroglobulin, it appears that this recycling occurs via the Golgi compartment.	Carbohydrates	17-29	thyroglobulin	Homo sapiens	63-76
10229914-1	1999	Thyroglobulin (Tg) present in the serum of normal individuals and patients with thyroid disorders could be partly newly synthesized non-iodinated Tg and partly Tg containing iodine and hormone residues originating from the lumen of thyroid follicles.	Iodine	174-180	thyroglobulin	Homo sapiens	0-13
10229914-1	1999	Thyroglobulin (Tg) present in the serum of normal individuals and patients with thyroid disorders could be partly newly synthesized non-iodinated Tg and partly Tg containing iodine and hormone residues originating from the lumen of thyroid follicles.	Iodine	174-180	thyroglobulin	Homo sapiens	15-17
10401666-6	1999	We now show that follicular TG, 27S &gt; 19S &gt; 12S, counter-regulates TSH-increased thyroid-specific gene transcription by suppressing the expression of the TTF-1, TTF-2, and Pax-8 genes.	Thyrotropin	73-76	thyroglobulin	Homo sapiens	28-30
10229914-6	1999	Labeled anti-T4 and anti-T3 mAbs bound to adsorbed purified Tg in amounts related to its iodine content.	Iodine	89-95	thyroglobulin	Homo sapiens	60-62
10229914-9	1999	The patient with DTC, whose serum Tg contained T4 and T3, represented a case of hyperthyroidism caused by a metastatic follicular carcinoma.	dtc	17-20	thyroglobulin	Homo sapiens	34-36
10229914-11	1999	The presence of Tg with hormone residues in serum is occasional in GD and DTC but is a common and probably distinctive feature of ST.	dtc	74-77	thyroglobulin	Homo sapiens	16-18
10365673-5	1999	The Tg fold response to rhTSH (rhTSH-stimulated Tg/basal Tg) is an index of the tumor"s sensitivity to TSH.	Thyrotropin	26-29	thyroglobulin	Homo sapiens	4-6
10365673-5	1999	The Tg fold response to rhTSH (rhTSH-stimulated Tg/basal Tg) is an index of the tumor"s sensitivity to TSH.	Thyrotropin	26-29	thyroglobulin	Homo sapiens	48-50
10365673-5	1999	The Tg fold response to rhTSH (rhTSH-stimulated Tg/basal Tg) is an index of the tumor"s sensitivity to TSH.	Thyrotropin	26-29	thyroglobulin	Homo sapiens	48-50
10365673-6	1999	Normal thyroid remnant and well-differentiated thyroid tumors display a greater (&gt;10-fold) serum Tg response to TSH stimulation compared with less well-differentiated tumors (&lt;3-fold).	Thyrotropin	115-118	thyroglobulin	Homo sapiens	100-102
10365673-9	1999	Thyroglobulin autoantibodies are present in approximately 20% of all DTC patients and cause either underestimation or overestimation of serum Tg measurements made by immunometric assay (IMA) and radioimmunoassay (RIA) methods, respectively.	dtc	69-72	thyroglobulin	Homo sapiens	0-13
10365673-13	1999	The development of a low (&lt;1 ng/mL) serum Tg (on LT4 therapy) by the second postoperative year signifies a low 5-year recurrence risk whereas a rising serum Tg in the face of TSH suppression is an abnormal response consistent with recurrence.	Thyrotropin	178-181	thyroglobulin	Homo sapiens	45-47
10190023-7	1999	Asparagine or aspartic acid has been reported as the major N-terminal amino acid for thyroglobulins of several animal species whereas glutamic acid is the sole N-terminal amino acid for buffalo thyroglobulin.	Asparagine	0-10	thyroglobulin	Homo sapiens	85-98
10199792-0	1999	Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter.	Cysteine	10-18	thyroglobulin	Homo sapiens	56-69
10199792-0	1999	Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter.	Cysteine	10-18	thyroglobulin	Homo sapiens	115-128
10199792-9	1999	We first analyzed the carbohydrate residues of C1263R Tg and C1995S Tg.	Carbohydrates	22-34	thyroglobulin	Homo sapiens	54-56
10199792-9	1999	We first analyzed the carbohydrate residues of C1263R Tg and C1995S Tg.	Carbohydrates	22-34	thyroglobulin	Homo sapiens	68-70
10199792-13	1999	Our results suggest that missense mutations that replace cysteine with either arginine or serine cause an abnormal three-dimensional structure of Tg.	Cysteine	57-65	thyroglobulin	Homo sapiens	146-148
10199792-13	1999	Our results suggest that missense mutations that replace cysteine with either arginine or serine cause an abnormal three-dimensional structure of Tg.	Arginine	78-86	thyroglobulin	Homo sapiens	146-148
10199792-13	1999	Our results suggest that missense mutations that replace cysteine with either arginine or serine cause an abnormal three-dimensional structure of Tg.	Serine	90-96	thyroglobulin	Homo sapiens	146-148
10190023-7	1999	Asparagine or aspartic acid has been reported as the major N-terminal amino acid for thyroglobulins of several animal species whereas glutamic acid is the sole N-terminal amino acid for buffalo thyroglobulin.	Aspartic Acid	14-27	thyroglobulin	Homo sapiens	85-98
10190023-8	1999	As a glycoprotein, thyroglobulin contains 8-10% total carbohydrate with galactose, mannose, fucose, N-acetyl glucosamine and sialic acid residues.	Carbohydrates	54-66	thyroglobulin	Homo sapiens	19-32
10190023-8	1999	As a glycoprotein, thyroglobulin contains 8-10% total carbohydrate with galactose, mannose, fucose, N-acetyl glucosamine and sialic acid residues.	Galactose	72-81	thyroglobulin	Homo sapiens	19-32
10190023-8	1999	As a glycoprotein, thyroglobulin contains 8-10% total carbohydrate with galactose, mannose, fucose, N-acetyl glucosamine and sialic acid residues.	Mannose	83-90	thyroglobulin	Homo sapiens	19-32
10190023-8	1999	As a glycoprotein, thyroglobulin contains 8-10% total carbohydrate with galactose, mannose, fucose, N-acetyl glucosamine and sialic acid residues.	Fucose	92-98	thyroglobulin	Homo sapiens	19-32
10190023-8	1999	As a glycoprotein, thyroglobulin contains 8-10% total carbohydrate with galactose, mannose, fucose, N-acetyl glucosamine and sialic acid residues.	Acetylglucosamine	100-120	thyroglobulin	Homo sapiens	19-32
10190023-8	1999	As a glycoprotein, thyroglobulin contains 8-10% total carbohydrate with galactose, mannose, fucose, N-acetyl glucosamine and sialic acid residues.	N-Acetylneuraminic Acid	125-136	thyroglobulin	Homo sapiens	19-32
10190023-10	1999	In addition, human thyroglobulin has carbohydrate unit C. The occurrence of sulfate and phosphate as Gal-3-SO4 and Man-6-PO4, respectively, has been reported in few species.	Carbohydrates	37-49	thyroglobulin	Homo sapiens	19-32
10190023-10	1999	In addition, human thyroglobulin has carbohydrate unit C. The occurrence of sulfate and phosphate as Gal-3-SO4 and Man-6-PO4, respectively, has been reported in few species.	Sulfates	76-83	thyroglobulin	Homo sapiens	19-32
10190023-10	1999	In addition, human thyroglobulin has carbohydrate unit C. The occurrence of sulfate and phosphate as Gal-3-SO4 and Man-6-PO4, respectively, has been reported in few species.	Phosphates	88-97	thyroglobulin	Homo sapiens	19-32
10190023-10	1999	In addition, human thyroglobulin has carbohydrate unit C. The occurrence of sulfate and phosphate as Gal-3-SO4 and Man-6-PO4, respectively, has been reported in few species.	gal-3-so4	101-110	thyroglobulin	Homo sapiens	19-32
10727002-8	1999	This confirmatory study has clearly shown that 1) rhTSH administration significantly increases sensitivity of serum Tg measurement in patients on THST; and 2) by permitting sensitive diagnostic follow-up with serum Tg measurement and/or radioiodine WBS during THST, rhTSH administration improves patient comfort and quality of life compared to THST withdrawal.	thst	146-150	thyroglobulin	Homo sapiens	116-118
10543413-4	1999	In a highly differentiated thyroid carcinoma cell line of Hurthle cell origin (XTC), we tested the hypothesis that TSH would stimulate thyroglobulin secretion (a differentiated function) more than EGF, and EGF would stimulate invasion (a de-differentiated function) more than TSH.	Thyrotropin	115-118	thyroglobulin	Homo sapiens	135-148
10727002-5	1999	However, major limitations of serum Tg testing are interference by serum anti-Tg antibodies and decreased sensitivity during THST.	thst	125-129	thyroglobulin	Homo sapiens	36-38
10727004-3	1999	The Roundtable included a panel discussion centering on three major topics: 1) rationale for use of exogenous versus endogenous TSH stimulation of radioiodine uptake and thyroglobulin (Tg) production; 2) impact and use of rhTSH in diagnostic follow-up; and 3) role of rhTSH in radioablation.	Thyrotropin	128-131	thyroglobulin	Homo sapiens	170-183
9851791-4	1998	Thyroglobulin mRNA was amplified from peripheral blood of 77 patients who had undergone thyroidectomy for well differentiated thyroid cancer, 68 of whom while taking thyroid hormone for TSH suppression.	Thyrotropin	186-189	thyroglobulin	Homo sapiens	0-13
9851791-7	1998	Among patients taking T4, thyroglobulin mRNA was detected in 26 of 33 patients with either thyroid bed or metastatic iodine-avid tissue on most recent withdrawal scan (79%), whereas serum thyroglobulin was detected in 12 of these 33 patients (36%; P &lt; 0.001).	Iodine	117-123	thyroglobulin	Homo sapiens	26-39
9851791-8	1998	Thyroglobulin mRNA was detected in 7 of 35 patients (20%) with negative radioiodine scans, 12 of 19 patients (63%) with radioiodine uptake in the thyroid bed, and all 14 patients with metastases, including 2 patients with antithyroglobulin antibodies.	Iodine-131	72-83	thyroglobulin	Homo sapiens	0-13
9851791-8	1998	Thyroglobulin mRNA was detected in 7 of 35 patients (20%) with negative radioiodine scans, 12 of 19 patients (63%) with radioiodine uptake in the thyroid bed, and all 14 patients with metastases, including 2 patients with antithyroglobulin antibodies.	Iodine-131	120-131	thyroglobulin	Homo sapiens	0-13
9849814-0	1998	Analyses of the molecular forms of serum thyroglobulin from patients with Graves" disease, subacute thyroiditis or differentiated thyroid cancer by velocity sedimentation on sucrose gradient and Western blot.	Sucrose	174-181	thyroglobulin	Homo sapiens	41-54
9591591-1	1998	UNLABELLED: Determination of thyroglobulin (Tg) levels, determined under endogenous thyroid-stimulating hormone stimulation after withdrawal of L-thyroxin treatment (off-T4), has been proven to be the most sensitive method for evaluation of patients with recurrent malignancy or distant metastases.	Thyroxine	144-154	thyroglobulin	Homo sapiens	29-42
9687151-2	1998	We have shown previously that IFNgamma inhibited thyroglobulin (Tg) gene transcription, and that its action was mediated by an increase in intracellular calcium and inositol phosphates.	Inositol Phosphates	165-184	thyroglobulin	Homo sapiens	64-66
9687151-5	1998	Stimulation with TSH (10 mIU/l) and IFNgamma (500 IU/l) resulted in a twofold increase and a 60% reduction in the luciferase activity respectively, similar to the effect observed with the endogenous Tg gene.	Thyrotropin	17-20	thyroglobulin	Homo sapiens	199-201
9687151-9	1998	The turnover time of the nuclear protein lasted for only 4 h although the suppressive effect of IFNgamma on Tg gene transcription lasted for 48 h. The effect of IFNgamma was lost when the thyrocytes were co-treated with genistein, a specific tyrosine kinase inhibitor.	Genistein	220-229	thyroglobulin	Homo sapiens	108-110
9793053-4	1998	Thyroglobulin level, usually undetectable a few months after total thyroidectomy and metabolic irradiation with 131-iodine in patients without initial metastases, is absolutely necessary for interpreting the scintiscans.	Iodine-131	112-122	thyroglobulin	Homo sapiens	0-13
9790800-2	1998	Subsequent treatment with therapeutic doses of iodine-137 resulted in normalization of the elevated thyroglobulin level.	iodine-137	47-57	thyroglobulin	Homo sapiens	100-113
9717981-2	1998	Human Tg, the site of synthesis of thyroid hormones, thyroxine (T4) and triiodothyronine (T3), is one of the major autoantigens in autoimmune thyroiditis.	Thyroxine	53-62	thyroglobulin	Homo sapiens	6-8
9717981-2	1998	Human Tg, the site of synthesis of thyroid hormones, thyroxine (T4) and triiodothyronine (T3), is one of the major autoantigens in autoimmune thyroiditis.	Triiodothyronine	72-88	thyroglobulin	Homo sapiens	6-8
9717981-2	1998	Human Tg, the site of synthesis of thyroid hormones, thyroxine (T4) and triiodothyronine (T3), is one of the major autoantigens in autoimmune thyroiditis.	Triiodothyronine	90-92	thyroglobulin	Homo sapiens	6-8
9717982-5	1998	In the present study, we report that the binding of MoAb 42C3 to iodinated Tg is inhibited by T4, T3, reverse T3 (rT3), triiodothyroacetic acid (triac), diiodothyronine (T2), diiodotyrosine (DIT), but not by thyronine (TO) or tyrosine.	3,3',5-triiodothyroacetic acid	120-143	thyroglobulin	Homo sapiens	75-77
9717982-5	1998	In the present study, we report that the binding of MoAb 42C3 to iodinated Tg is inhibited by T4, T3, reverse T3 (rT3), triiodothyroacetic acid (triac), diiodothyronine (T2), diiodotyrosine (DIT), but not by thyronine (TO) or tyrosine.	3,3',5-triiodothyroacetic acid	145-150	thyroglobulin	Homo sapiens	75-77
9717982-5	1998	In the present study, we report that the binding of MoAb 42C3 to iodinated Tg is inhibited by T4, T3, reverse T3 (rT3), triiodothyroacetic acid (triac), diiodothyronine (T2), diiodotyrosine (DIT), but not by thyronine (TO) or tyrosine.	Diiodothyronines	153-168	thyroglobulin	Homo sapiens	75-77
9717982-5	1998	In the present study, we report that the binding of MoAb 42C3 to iodinated Tg is inhibited by T4, T3, reverse T3 (rT3), triiodothyroacetic acid (triac), diiodothyronine (T2), diiodotyrosine (DIT), but not by thyronine (TO) or tyrosine.	Diiodotyrosine	175-189	thyroglobulin	Homo sapiens	75-77
9717982-5	1998	In the present study, we report that the binding of MoAb 42C3 to iodinated Tg is inhibited by T4, T3, reverse T3 (rT3), triiodothyroacetic acid (triac), diiodothyronine (T2), diiodotyrosine (DIT), but not by thyronine (TO) or tyrosine.	Diiodotyrosine	191-194	thyroglobulin	Homo sapiens	75-77
9717982-5	1998	In the present study, we report that the binding of MoAb 42C3 to iodinated Tg is inhibited by T4, T3, reverse T3 (rT3), triiodothyroacetic acid (triac), diiodothyronine (T2), diiodotyrosine (DIT), but not by thyronine (TO) or tyrosine.	Thyronines	159-168	thyroglobulin	Homo sapiens	75-77
9717982-5	1998	In the present study, we report that the binding of MoAb 42C3 to iodinated Tg is inhibited by T4, T3, reverse T3 (rT3), triiodothyroacetic acid (triac), diiodothyronine (T2), diiodotyrosine (DIT), but not by thyronine (TO) or tyrosine.	Tyrosine	181-189	thyroglobulin	Homo sapiens	75-77
9653173-7	1998	In this report we show that follicular TG counter-regulates TSH-increased, thyroid-specific gene transcription by suppressing expression of the TTF-1, TTF-2, and Pax-8 genes.	Thyrotropin	60-63	thyroglobulin	Homo sapiens	39-41
9723881-1	1998	The binding of Ca2+ ions to bovine and human thyroglobulin (Tg) was demonstrated qualitatively by 45Ca overlay on polyvinylidene difluoride (PVDF) membranes.	polyvinylidene fluoride	114-139	thyroglobulin	Homo sapiens	45-58
9723881-1	1998	The binding of Ca2+ ions to bovine and human thyroglobulin (Tg) was demonstrated qualitatively by 45Ca overlay on polyvinylidene difluoride (PVDF) membranes.	polyvinylidene fluoride	114-139	thyroglobulin	Homo sapiens	60-62
9723881-1	1998	The binding of Ca2+ ions to bovine and human thyroglobulin (Tg) was demonstrated qualitatively by 45Ca overlay on polyvinylidene difluoride (PVDF) membranes.	polyvinylidene fluoride	141-145	thyroglobulin	Homo sapiens	45-58
9723881-1	1998	The binding of Ca2+ ions to bovine and human thyroglobulin (Tg) was demonstrated qualitatively by 45Ca overlay on polyvinylidene difluoride (PVDF) membranes.	polyvinylidene fluoride	141-145	thyroglobulin	Homo sapiens	60-62
9623499-0	1998	Iodine is essential for human T cell recognition of human thyroglobulin.	Iodine	0-6	thyroglobulin	Homo sapiens	58-71
9641890-0	1998	Positron emission tomography with F-18-deoxyglucose in patients with differentiated thyroid carcinoma, elevated thyroglobulin levels, and negative iodine scans.	f-18-deoxyglucose	34-51	thyroglobulin	Homo sapiens	112-125
9641890-1	1998	INTRODUCTION: In patients with differentiated thyroid carcinoma, elevated serum levels of thyroglobulin (hTg) may occur in spite of otherwise negative diagnostic procedures and in particular in spite of a negative iodine-131 scan.	Iodine	214-220	thyroglobulin	Homo sapiens	90-103
9514162-7	1998	Moreover, two-dimensional gel analysis showed that BiP associated especially well with intracellular Tg containing mispaired disulfide bonds, thought to represent early Tg folding intermediates.	Disulfides	125-134	thyroglobulin	Homo sapiens	101-103
9446787-0	1998	Role of multimerized porcine thyroglobulin in iodine storage.	Iodine	46-52	thyroglobulin	Homo sapiens	29-42
9446787-1	1998	Thyroglobulin (Tg), the prothyroid hormone, is stored in the lumen of the thyroid follicles as soluble dimers and tetramers and insoluble multimers, Soluble Tg is well characterized with regards to structure and role, but insoluble Tg (i-Tg) is not.	prothyroid hormone	24-42	thyroglobulin	Homo sapiens	0-13
9446787-1	1998	Thyroglobulin (Tg), the prothyroid hormone, is stored in the lumen of the thyroid follicles as soluble dimers and tetramers and insoluble multimers, Soluble Tg is well characterized with regards to structure and role, but insoluble Tg (i-Tg) is not.	prothyroid hormone	24-42	thyroglobulin	Homo sapiens	15-17
9446787-1	1998	Thyroglobulin (Tg), the prothyroid hormone, is stored in the lumen of the thyroid follicles as soluble dimers and tetramers and insoluble multimers, Soluble Tg is well characterized with regards to structure and role, but insoluble Tg (i-Tg) is not.	prothyroid hormone	24-42	thyroglobulin	Homo sapiens	157-159
9446787-1	1998	Thyroglobulin (Tg), the prothyroid hormone, is stored in the lumen of the thyroid follicles as soluble dimers and tetramers and insoluble multimers, Soluble Tg is well characterized with regards to structure and role, but insoluble Tg (i-Tg) is not.	prothyroid hormone	24-42	thyroglobulin	Homo sapiens	157-159
9446787-1	1998	Thyroglobulin (Tg), the prothyroid hormone, is stored in the lumen of the thyroid follicles as soluble dimers and tetramers and insoluble multimers, Soluble Tg is well characterized with regards to structure and role, but insoluble Tg (i-Tg) is not.	prothyroid hormone	24-42	thyroglobulin	Homo sapiens	157-159
9446787-2	1998	Here we show that i-Tg, multimerized through formation of disulfide and dityrosine bonds, has a higher iodine content than soluble Tg and no thyroid hormones.	Disulfides	58-67	thyroglobulin	Homo sapiens	20-22
9446787-2	1998	Here we show that i-Tg, multimerized through formation of disulfide and dityrosine bonds, has a higher iodine content than soluble Tg and no thyroid hormones.	dityrosine	72-82	thyroglobulin	Homo sapiens	20-22
9446787-2	1998	Here we show that i-Tg, multimerized through formation of disulfide and dityrosine bonds, has a higher iodine content than soluble Tg and no thyroid hormones.	Iodine	103-109	thyroglobulin	Homo sapiens	20-22
9588493-2	1998	Analysis of the Tg mRNA in the goiter of one of the siblings revealed a cytosine to thymine transition creating a stop codon at position 1510.	Cytosine	72-80	thyroglobulin	Homo sapiens	16-18
9588493-2	1998	Analysis of the Tg mRNA in the goiter of one of the siblings revealed a cytosine to thymine transition creating a stop codon at position 1510.	Thymine	84-91	thyroglobulin	Homo sapiens	16-18
9616241-9	1998	Factors identified as influencing response to 131I therapy included age, clinical stage, survival, recurrence, extent of surgery and the 1 month post-operative serum thyroglobulin (Tg) level.	Iodine-131	46-50	thyroglobulin	Homo sapiens	166-179
9616241-9	1998	Factors identified as influencing response to 131I therapy included age, clinical stage, survival, recurrence, extent of surgery and the 1 month post-operative serum thyroglobulin (Tg) level.	Iodine-131	46-50	thyroglobulin	Homo sapiens	181-183
9623499-1	1998	Here we describe for the first time that recognition by human T cells of human thyroglobulin depends upon its iodine content.	Iodine	110-116	thyroglobulin	Homo sapiens	79-92
9367184-6	1997	As a result, it was revealed that the Tg fraction eluted at higher ionic strength from a DEAE-cellulose column is apt to contain more of each iodoamino acid, as well as total content of iodine, larger negative zeta-potential, conforming to sialic acid content in the Tg molecule and to a higher content of di-sialo-bi-antennary complex and to high mannose type oligosaccharides.	DEAE-Cellulose	89-103	thyroglobulin	Homo sapiens	38-40
9344702-1	1997	A few synthetic peptides corresponding to amino acid sequences on human thyroglobulin (Tg) have been reported to induce moderate thyroiditis or activate mouse Tg (MTg)-primed T cells to transfer thyroiditis in mice susceptible to experimental autoimmune thyroiditis.	(Methylthio)acetic acid	163-166	thyroglobulin	Homo sapiens	72-85
9344702-1	1997	A few synthetic peptides corresponding to amino acid sequences on human thyroglobulin (Tg) have been reported to induce moderate thyroiditis or activate mouse Tg (MTg)-primed T cells to transfer thyroiditis in mice susceptible to experimental autoimmune thyroiditis.	(Methylthio)acetic acid	163-166	thyroglobulin	Homo sapiens	87-89
9367184-0	1997	Carbohydrate analysis of porcine thyroglobulin isoforms with different iodine contents.	Carbohydrates	0-12	thyroglobulin	Homo sapiens	33-46
9362367-1	1997	Thyroglobulin (Tg), the precursor of the thyroid hormones triiodothyronine (T3) and thyroxine (T4), is known to derive from thyroid epithelial cells.	Triiodothyronine	58-74	thyroglobulin	Homo sapiens	0-13
9362367-1	1997	Thyroglobulin (Tg), the precursor of the thyroid hormones triiodothyronine (T3) and thyroxine (T4), is known to derive from thyroid epithelial cells.	Triiodothyronine	58-74	thyroglobulin	Homo sapiens	15-17
9362367-1	1997	Thyroglobulin (Tg), the precursor of the thyroid hormones triiodothyronine (T3) and thyroxine (T4), is known to derive from thyroid epithelial cells.	Triiodothyronine	76-78	thyroglobulin	Homo sapiens	0-13
9362367-1	1997	Thyroglobulin (Tg), the precursor of the thyroid hormones triiodothyronine (T3) and thyroxine (T4), is known to derive from thyroid epithelial cells.	Triiodothyronine	76-78	thyroglobulin	Homo sapiens	15-17
9362367-1	1997	Thyroglobulin (Tg), the precursor of the thyroid hormones triiodothyronine (T3) and thyroxine (T4), is known to derive from thyroid epithelial cells.	Thyroxine	84-93	thyroglobulin	Homo sapiens	0-13
9362367-1	1997	Thyroglobulin (Tg), the precursor of the thyroid hormones triiodothyronine (T3) and thyroxine (T4), is known to derive from thyroid epithelial cells.	Thyroxine	84-93	thyroglobulin	Homo sapiens	15-17
9362367-6	1997	To test this hypothesis, co-cultures of hepatocytes and macrophages were incubated with Tg, which resulted in the release of thyroid hormones and in a significant increase in the activity of lipogenesis and of hepatocellular key enzymes of the hexose monophosphate shunt.	hexose monophosphate	244-264	thyroglobulin	Homo sapiens	88-90
9367184-0	1997	Carbohydrate analysis of porcine thyroglobulin isoforms with different iodine contents.	Iodine	71-77	thyroglobulin	Homo sapiens	33-46
9367184-1	1997	To further validate the relationship between thyroid hormone formation and the carbohydrate structure of thyroglobulin (Tg), we reinvestigated the relationship between the iodine content and the asparagine-linked oligosaccharide structures of porcine Tg.	Carbohydrates	79-91	thyroglobulin	Homo sapiens	105-118
9367184-6	1997	As a result, it was revealed that the Tg fraction eluted at higher ionic strength from a DEAE-cellulose column is apt to contain more of each iodoamino acid, as well as total content of iodine, larger negative zeta-potential, conforming to sialic acid content in the Tg molecule and to a higher content of di-sialo-bi-antennary complex and to high mannose type oligosaccharides.	iodoamino acid	142-156	thyroglobulin	Homo sapiens	38-40
9367184-1	1997	To further validate the relationship between thyroid hormone formation and the carbohydrate structure of thyroglobulin (Tg), we reinvestigated the relationship between the iodine content and the asparagine-linked oligosaccharide structures of porcine Tg.	Carbohydrates	79-91	thyroglobulin	Homo sapiens	120-122
9367184-6	1997	As a result, it was revealed that the Tg fraction eluted at higher ionic strength from a DEAE-cellulose column is apt to contain more of each iodoamino acid, as well as total content of iodine, larger negative zeta-potential, conforming to sialic acid content in the Tg molecule and to a higher content of di-sialo-bi-antennary complex and to high mannose type oligosaccharides.	Iodine	186-192	thyroglobulin	Homo sapiens	38-40
9367184-6	1997	As a result, it was revealed that the Tg fraction eluted at higher ionic strength from a DEAE-cellulose column is apt to contain more of each iodoamino acid, as well as total content of iodine, larger negative zeta-potential, conforming to sialic acid content in the Tg molecule and to a higher content of di-sialo-bi-antennary complex and to high mannose type oligosaccharides.	N-Acetylneuraminic Acid	240-251	thyroglobulin	Homo sapiens	38-40
9367184-6	1997	As a result, it was revealed that the Tg fraction eluted at higher ionic strength from a DEAE-cellulose column is apt to contain more of each iodoamino acid, as well as total content of iodine, larger negative zeta-potential, conforming to sialic acid content in the Tg molecule and to a higher content of di-sialo-bi-antennary complex and to high mannose type oligosaccharides.	Mannose	348-355	thyroglobulin	Homo sapiens	38-40
9367184-6	1997	As a result, it was revealed that the Tg fraction eluted at higher ionic strength from a DEAE-cellulose column is apt to contain more of each iodoamino acid, as well as total content of iodine, larger negative zeta-potential, conforming to sialic acid content in the Tg molecule and to a higher content of di-sialo-bi-antennary complex and to high mannose type oligosaccharides.	Oligosaccharides	361-377	thyroglobulin	Homo sapiens	38-40
9367184-7	1997	These results support the conclusion that iodine organification of the Tg molecule is correlated with asparagine-linked oligosaccharide completion.	Iodine	42-48	thyroglobulin	Homo sapiens	71-73
9367184-7	1997	These results support the conclusion that iodine organification of the Tg molecule is correlated with asparagine-linked oligosaccharide completion.	asparagine-linked oligosaccharide	102-135	thyroglobulin	Homo sapiens	71-73
9329400-0	1997	Thyroglobulin-like immunoreactivity within goitrous thyroid stroma after iodine overload.	Iodine	73-79	thyroglobulin	Homo sapiens	0-13
9330589-2	1997	Previous studies have shown a high rate of visualization of uptake and a decrease in Tg after one or more therapeutic doses of 131I.	Iodine-131	127-131	thyroglobulin	Homo sapiens	85-87
9287346-2	1997	The last stages of thyroglobulin maturation occur in the thyroid follicular lumen and include thyroid hormone formation and glycan completion.	Polysaccharides	124-130	thyroglobulin	Homo sapiens	19-32
9287346-6	1997	Peptides containing the mAb epitopes were obtained by immunoscreening cyanogen bromide-derived native human thyroglobulin peptides and a cDNA thyroglobulin expression library.	Cyanogen Bromide	70-86	thyroglobulin	Homo sapiens	108-121
9330589-5	1997	Their serum Tg while on L-thyroxine ranged between 2.4 and 1173 pmol/l.	Thyroxine	24-35	thyroglobulin	Homo sapiens	12-14
9211756-2	1997	Diagnostic iodine-131 whole-body scan (WBS) and serum thyroglobulin (Tg) are important tools to detect thyroid remnants after thyroidectomy and radioiodine therapy.	Iodine-131	144-155	thyroglobulin	Homo sapiens	54-67
9255147-13	1997	Liver uptake on scan related to the fraction of 131I-labeled thyroglobulin in the serum.	Iodine-131	48-52	thyroglobulin	Homo sapiens	61-74
9225783-8	1997	The possibility of a false-positive finding on radioiodine scans should be considered, particularly when the serum thyroglobulin level is not elevated.	Iodine-131	47-58	thyroglobulin	Homo sapiens	115-128
9292947-0	1997	Identification of a new thyroglobulin variant: a guanine-to-adenine transition resulting in the substitution of arginine 2510 by glutamine.	Guanine	49-56	thyroglobulin	Homo sapiens	24-37
9292947-0	1997	Identification of a new thyroglobulin variant: a guanine-to-adenine transition resulting in the substitution of arginine 2510 by glutamine.	Adenine	60-67	thyroglobulin	Homo sapiens	24-37
9292948-2	1997	Thyrotropin (TSH) and thyroglobulin (Tg) can be used as surveillance indicators for assessing iodine deficiency disorders.	Iodine	94-100	thyroglobulin	Homo sapiens	22-35
9211756-2	1997	Diagnostic iodine-131 whole-body scan (WBS) and serum thyroglobulin (Tg) are important tools to detect thyroid remnants after thyroidectomy and radioiodine therapy.	Iodine-131	144-155	thyroglobulin	Homo sapiens	69-71
9211756-9	1997	Six months after the postoperative radioiodine treatment (first visit), the sensitivity of WBS and Tg was 87% and 26% respectively.	Iodine-131	35-46	thyroglobulin	Homo sapiens	99-101
9211756-12	1997	Our data indicate that in early diagnosed thyroid cancer, serum Tg measured 6 months after the postoperative 131I ablative dose is less sensitive than WBS for the demonstration of persistence of residual thyroid tissue but provides predictive information on the disease course.	Iodine-131	109-113	thyroglobulin	Homo sapiens	64-66
9211756-13	1997	WBS(+) and Tg(-) patients are cured earlier and with less radioiodine than those who remain Tg(+).	Iodine-131	58-69	thyroglobulin	Homo sapiens	11-13
9212886-2	1997	VB5 was able to immunostain cytoplasmic thyroglobulin (Tg) in the acetone-fixed cancer cells when used in a labeled streptavidin-biotin method but not in a conventional indirect immunoperoxidase technique.	Acetone	66-73	thyroglobulin	Homo sapiens	40-53
9226201-1	1997	Serum thyroglobulin has been measured sequentially in 47 patients with differentiated thyroid cancer who had been treated by surgery and I-thyroxine, but no radioiodine (131I).	i-thyroxine	137-148	thyroglobulin	Homo sapiens	6-19
9212886-2	1997	VB5 was able to immunostain cytoplasmic thyroglobulin (Tg) in the acetone-fixed cancer cells when used in a labeled streptavidin-biotin method but not in a conventional indirect immunoperoxidase technique.	Biotin	129-135	thyroglobulin	Homo sapiens	40-53
9186272-8	1997	The TG cDNA constructs were transiently transfected in HTori 3 and COS-1 cells and protein expression was detected using a polyclonal anti-human-TG on fixed cells and after SDS-PAGE.	Sodium Dodecyl Sulfate	173-176	thyroglobulin	Homo sapiens	4-6
9112403-4	1997	TSH-stimulated cultured human thyroid cells exposed for 72 h to IL-1beta (0.0002-20 microg/liter = 1-105 IU/liter) exhibited a dose-dependent and reversible inhibition of thyroglobulin and cAMP release and a dose-dependent stimulation of cGMP and IL-6 release.	Thyrotropin	0-3	thyroglobulin	Homo sapiens	171-184
9186272-10	1997	The mannose structures detected on the proteins by lectins and localization after expression in the cells suggest that only the N-terminal TG fragment (containing the SP) is directed to the endoplasmatic reticulum but is unable to reach the Golgi complex.	Mannose	4-11	thyroglobulin	Homo sapiens	139-141
9186272-10	1997	The mannose structures detected on the proteins by lectins and localization after expression in the cells suggest that only the N-terminal TG fragment (containing the SP) is directed to the endoplasmatic reticulum but is unable to reach the Golgi complex.	Protein Sorting Signals	167-169	thyroglobulin	Homo sapiens	139-141
9163323-0	1997	A zinc-dependent DNA-binding activity co-operates with cAMP-responsive-element-binding protein to activate the human thyroglobulin enhancer.	Cyclic AMP	55-59	thyroglobulin	Homo sapiens	117-130
9041169-7	1997	There was significant radioactive iodine uptake in the thyroid bed and in a palpable right supraclavicular lymph node; this was associated with an increased serum thyroglobulin level.	radioactive iodine	22-40	thyroglobulin	Homo sapiens	163-176
9133699-0	1997	131I therapy for elevated thyroglobulin levels.	Iodine-131	0-4	thyroglobulin	Homo sapiens	26-39
9144857-5	1997	Another topic of interest is the administration of 131I therapy to patients whose serum thyroglobulin levels are abnormal but whose diagnostic 131I scans are negative.	Iodine-131	51-55	thyroglobulin	Homo sapiens	88-101
9144857-6	1997	Because the 131I scans after therapy are often abnormal in these patients and a reduction of serum thyroglobulin can occur, this approach seems effective.	Iodine-131	12-16	thyroglobulin	Homo sapiens	99-112
8902853-1	1996	We previously showed that thyroglobulin (Tg) glycosylation is enhanced 1.5-fold under thyrotropin (TSH) stimulation, corresponding to an increased number of oligosaccharide chains per molecule of Tg.	Oligosaccharides	157-172	thyroglobulin	Homo sapiens	26-39
8900403-1	1996	Previous studies indicate that when low iodine thyroglobulin (Tg) is iodinated enzymatically with thyroid peroxidase (TPO), the tyrosyl residues that are used for the formation of thyroid hormone (hormonogenic sites) are selected for early iodination.	cyclo(tyrosyl-tyrosyl)	128-135	thyroglobulin	Homo sapiens	47-60
8900403-1	1996	Previous studies indicate that when low iodine thyroglobulin (Tg) is iodinated enzymatically with thyroid peroxidase (TPO), the tyrosyl residues that are used for the formation of thyroid hormone (hormonogenic sites) are selected for early iodination.	cyclo(tyrosyl-tyrosyl)	128-135	thyroglobulin	Homo sapiens	62-64
8900403-3	1996	For this purpose, low iodine human Tg (2.0 atoms I per 660,000 dimer) was iodinated chemically with (125)I-(3) and enzymatically with TPO + 125I- to a matched low level of iodination (approximately 8 added I atoms per molecule).	Iodine	22-28	thyroglobulin	Homo sapiens	35-37
8900403-6	1996	From the sequence information and the known amino acid sequence of Tg, it was possible to define the location of the iodinated tyrosyl residues.	cyclo(tyrosyl-tyrosyl)	127-134	thyroglobulin	Homo sapiens	67-69
8900403-10	1996	Our observation that the same hormonogenic tyrosyl sites are iodinated by chemical as well as enzymatic iodination indicates that preferential iodination of hormonogenic sites is dependent primarily on the native structure of Tg.	cyclo(tyrosyl-tyrosyl)	43-50	thyroglobulin	Homo sapiens	226-228
8900403-11	1996	TPO plays a minor role, if any, in the selection of early tyrosyl iodination sites in Tg.	cyclo(tyrosyl-tyrosyl)	58-65	thyroglobulin	Homo sapiens	86-88
8900403-12	1996	Consistent with this conclusion was our finding that chemical iodination, as well as enzymatic iodination, led to formation of uniformly iodinated Tg, as determined by isopycnic centrifugation in rubidium chloride.	rubidium chloride	196-213	thyroglobulin	Homo sapiens	147-149
8900403-13	1996	However, we observed a slightly higher diiodotyrosine (DIT) content and a correspondingly lower monoiodotyrosine content in enzymatically iodinated Tg, compared to matched chemically iodinated Tg.	Monoiodotyrosine	96-112	thyroglobulin	Homo sapiens	148-150
8902853-1	1996	We previously showed that thyroglobulin (Tg) glycosylation is enhanced 1.5-fold under thyrotropin (TSH) stimulation, corresponding to an increased number of oligosaccharide chains per molecule of Tg.	Oligosaccharides	157-172	thyroglobulin	Homo sapiens	196-198
8902853-7	1996	The amount of lipid carriers appeared to be insufficiently increased but no component is a limiting step, suggesting that the turnover of dolichol derivatives may be increased under TSH control through their use by higher amounts of Tg.	Dolichols	138-146	thyroglobulin	Homo sapiens	233-235
8943171-8	1997	The thyroglobulin levels fell significantly over the 52-week follow-up period in the iodide group.	Iodides	85-91	thyroglobulin	Homo sapiens	4-17
8981932-5	1996	We have confirmed biochemically that most intrathyroidal thyroglobulin fails to reach the (Golgi) compartment where complex carbohydrate modification takes place.	Carbohydrates	124-136	thyroglobulin	Homo sapiens	57-70
8970514-1	1996	UNLABELLED: Serum thyroglobulin (Tg) is a suitable marker for differentiated thyroid carcinoma after total thyroid ablation by surgery and 131I therapy.	Iodine-131	139-143	thyroglobulin	Homo sapiens	18-31
8902853-1	1996	We previously showed that thyroglobulin (Tg) glycosylation is enhanced 1.5-fold under thyrotropin (TSH) stimulation, corresponding to an increased number of oligosaccharide chains per molecule of Tg.	Oligosaccharides	157-172	thyroglobulin	Homo sapiens	41-43
8790195-6	1996	In six patients with increasing human thyroglobulin levels, we found that 18FDG whole-body PET localized positive neck metastases of papillary thyroid carcinomas that were histologically confirmed after extirpation.	Fluorodeoxyglucose F18	74-79	thyroglobulin	Homo sapiens	38-51
8697622-3	1996	We hypothesize that if THAA arise through an immune response to iodothyronines carried by circulating thyroglobulin (hTg), THAA should be found together with autoantibodies against the peptide backbone of hTg (TPAA) close to the hormone-forming sites.	thaa	23-27	thyroglobulin	Homo sapiens	102-115
8754751-6	1996	After more extended digestion, it also acted as an exopeptidase, producing the dipeptide T4-Gln, corresponding to residues 5 and 6 of Tg.	dipeptide t4-gln	79-95	thyroglobulin	Homo sapiens	134-136
8754751-10	1996	We conclude that the N-terminus of Tg, which contains its major hormonogenic site, is particularly susceptible to hydrolysis by the endopeptidase cathepsin B and that cathepsin B additionally has an important exopeptidase action that allows it to release a T4 dipeptide that is then further degraded by LDPI to release free T4.	Dipeptides	260-269	thyroglobulin	Homo sapiens	35-37
8697622-3	1996	We hypothesize that if THAA arise through an immune response to iodothyronines carried by circulating thyroglobulin (hTg), THAA should be found together with autoantibodies against the peptide backbone of hTg (TPAA) close to the hormone-forming sites.	iodothyronines	64-78	thyroglobulin	Homo sapiens	102-115
8626858-9	1996	The results show that part of extracellular human TG undergoes multimerization, primarily by the formation of intermolecular disulfide bonds, thus allowing the storage of TG at excessively high, previously unknown, concentrations.	Disulfides	125-134	thyroglobulin	Homo sapiens	50-52
8652666-0	1996	Identification of a thyroid-specific and cAMP-responsive enhancer in the upstream sequences of the human thyroglobulin promoter.	Cyclic AMP	41-45	thyroglobulin	Homo sapiens	105-118
8626858-9	1996	The results show that part of extracellular human TG undergoes multimerization, primarily by the formation of intermolecular disulfide bonds, thus allowing the storage of TG at excessively high, previously unknown, concentrations.	Disulfides	125-134	thyroglobulin	Homo sapiens	171-173
8647316-9	1996	In the secondary culture the TSH-stimulated Tg production decreased from 253 ng/micrograms DNA (205-263) after 3 weeks to 18 ng/micrograms DNA (6-81), P &lt; 0.001, n = 6 after 12 weeks and TSH-stimulated cAMP production from 660 pmol/micrograms DNA (500-840) to 60 (40-200), P &lt; 0.001, n = 6.	Thyrotropin	29-32	thyroglobulin	Homo sapiens	44-46
8616533-0	1996	Hypothyroid patients showing shortened responsiveness to oral iodized oil have paradoxically low serum thyroglobulin and low thyroid reserve.	Oils	70-73	thyroglobulin	Homo sapiens	103-116
8616533-17	1996	We show that the serum TG/TSH ratio may be used as a predictive index of thyroid reserve and of positive response to iodine administration.	Thyrotropin	26-29	thyroglobulin	Homo sapiens	23-25
8616533-17	1996	We show that the serum TG/TSH ratio may be used as a predictive index of thyroid reserve and of positive response to iodine administration.	Iodine	117-123	thyroglobulin	Homo sapiens	23-25
8647316-9	1996	In the secondary culture the TSH-stimulated Tg production decreased from 253 ng/micrograms DNA (205-263) after 3 weeks to 18 ng/micrograms DNA (6-81), P &lt; 0.001, n = 6 after 12 weeks and TSH-stimulated cAMP production from 660 pmol/micrograms DNA (500-840) to 60 (40-200), P &lt; 0.001, n = 6.	Thyrotropin	190-193	thyroglobulin	Homo sapiens	44-46
8647316-7	1996	Furthermore, a preserved ability of TSH-stimulated production of Tg and cAMP in 12-week-old secondary and tertiary cultures was found.	Thyrotropin	36-39	thyroglobulin	Homo sapiens	65-67
8647316-9	1996	In the secondary culture the TSH-stimulated Tg production decreased from 253 ng/micrograms DNA (205-263) after 3 weeks to 18 ng/micrograms DNA (6-81), P &lt; 0.001, n = 6 after 12 weeks and TSH-stimulated cAMP production from 660 pmol/micrograms DNA (500-840) to 60 (40-200), P &lt; 0.001, n = 6.	Cyclic AMP	205-209	thyroglobulin	Homo sapiens	44-46
9092301-5	1996	The physicochemical characterization showed by polyacrylamide gel electrophoresis and immunoblotting that the purified Tg had for the major part the expected molecular size of 660 kDa with traces of lower molecular forms.	polyacrylamide	47-61	thyroglobulin	Homo sapiens	119-121
8777378-0	1996	The effect of oral administration of iodine to patients with goiter and hypothyroidism due to defective synthesis of thyroglobulin.	Iodine	37-43	thyroglobulin	Homo sapiens	117-130
9092301-6	1996	The amino acid composition was close to that demonstrated for the cDNA and the content of iodine was in keeping with a moderately to highly iodinated Tg.	Iodine	90-96	thyroglobulin	Homo sapiens	150-152
7744991-0	1995	Iodine-131 therapy for thyroid cancer patients with elevated thyroglobulin and negative diagnostic scan.	Iodine	0-6	thyroglobulin	Homo sapiens	61-74
8778159-14	1995	Our observations suggest the usefulness of ultrastructural thyroid evaluation and serial plasma thyroglobulin determinations to thoroughly evaluate the underlying pathogenetic mechanisms in amiodarone-associated thyrotoxicosis with apparently normal thyroid glands.	Amiodarone	190-200	thyroglobulin	Homo sapiens	96-109
15251584-1	1995	The introduction of the new assays for thyroglobulin (Tg) with a sensitivity of 1 to 3 mg/L has made it unnecessary to terminate thyroxine suppression therapy to determine Tg level.	Thyroxine	129-138	thyroglobulin	Homo sapiens	39-52
15251584-1	1995	The introduction of the new assays for thyroglobulin (Tg) with a sensitivity of 1 to 3 mg/L has made it unnecessary to terminate thyroxine suppression therapy to determine Tg level.	Thyroxine	129-138	thyroglobulin	Homo sapiens	54-56
15251584-7	1995	Monitoring the Tg level reliably detects early recurrent disease in patients who have undergone a surgical procedure for thyroid carcinoma and are receiving thyroxine suppression therapy.	Thyroxine	157-166	thyroglobulin	Homo sapiens	15-17
15251584-8	1995	Only those patients with Tg levels that exceed 3 to 5 mg/L or with clinical evidence of recurrence need to discontinue thyroxine treatment and have a 131 I scan.	Thyroxine	119-128	thyroglobulin	Homo sapiens	25-27
7793989-0	1995	Characterization of hormonogenic sites in an N-terminal, cyanogen bromide fragment of human thyroglobulin.	Cyanogen Bromide	57-73	thyroglobulin	Homo sapiens	92-105
7793989-3	1995	207, 302-306, 1986) that substantial thyroxine formation occurs on enzymatic iodination of a 171-residue, N-terminal cyanogen bromide (CNBr) fragment of human goiter thyroglobulin.	Thyroxine	37-46	thyroglobulin	Homo sapiens	166-179
7793989-3	1995	207, 302-306, 1986) that substantial thyroxine formation occurs on enzymatic iodination of a 171-residue, N-terminal cyanogen bromide (CNBr) fragment of human goiter thyroglobulin.	terminal	108-116	thyroglobulin	Homo sapiens	166-179
7793989-3	1995	207, 302-306, 1986) that substantial thyroxine formation occurs on enzymatic iodination of a 171-residue, N-terminal cyanogen bromide (CNBr) fragment of human goiter thyroglobulin.	Cyanogen Bromide	117-133	thyroglobulin	Homo sapiens	166-179
7793989-3	1995	207, 302-306, 1986) that substantial thyroxine formation occurs on enzymatic iodination of a 171-residue, N-terminal cyanogen bromide (CNBr) fragment of human goiter thyroglobulin.	Cyanogen Bromide	135-139	thyroglobulin	Homo sapiens	166-179
7793989-11	1995	Thus, while we have confirmed the finding that the N-terminal CNBr fragment of human goiter thyroglobulin is by itself capable of efficient thyroxine formation when enzymatically iodinated in vitro, we observed that the role of specific tyrosines in the hormone-forming process was different from that in intact thyroglobulin.	Thyroxine	140-149	thyroglobulin	Homo sapiens	92-105
7793989-11	1995	Thus, while we have confirmed the finding that the N-terminal CNBr fragment of human goiter thyroglobulin is by itself capable of efficient thyroxine formation when enzymatically iodinated in vitro, we observed that the role of specific tyrosines in the hormone-forming process was different from that in intact thyroglobulin.	Tyrosine	237-246	thyroglobulin	Homo sapiens	92-105
7749504-0	1995	Importance of the content and localization of tyrosine residues for thyroxine formation within the N-terminal part of human thyroglobulin.	Tyrosine	46-54	thyroglobulin	Homo sapiens	124-137
7749504-0	1995	Importance of the content and localization of tyrosine residues for thyroxine formation within the N-terminal part of human thyroglobulin.	Thyroxine	68-77	thyroglobulin	Homo sapiens	124-137
7749504-1	1995	Thyroxine (T4) is formed by coupling of iodinated tyrosine residues within thyroglobulin (TG).	Thyroxine	0-9	thyroglobulin	Homo sapiens	75-88
7749504-1	1995	Thyroxine (T4) is formed by coupling of iodinated tyrosine residues within thyroglobulin (TG).	Tyrosine	50-58	thyroglobulin	Homo sapiens	75-88
8855445-1	1996	It is known that a tyrosine free radical is produced during the hormonogenic iodination reaction of tyrosine residues on thyroglobulin.	Tyrosine	19-27	thyroglobulin	Homo sapiens	121-134
8855445-1	1996	It is known that a tyrosine free radical is produced during the hormonogenic iodination reaction of tyrosine residues on thyroglobulin.	Tyrosine	100-108	thyroglobulin	Homo sapiens	121-134
8855445-2	1996	In the hormonogenic region of thyroglobulin, phosphorylated tyrosine residues have been detected.	Tyrosine	60-68	thyroglobulin	Homo sapiens	30-43
8855445-6	1996	Our data may suggest a putative regulatory mechanism in thyroid hormone synthesis by phosphorylation of hormonogenic tyrosine residues on thyroglobulin.	Tyrosine	117-125	thyroglobulin	Homo sapiens	138-151
8530385-2	1995	Thyroglobulin (Tg) is the substrate for thyroid hormone biosynthesis, which requires tyrosine iodination and iodotyrosine coupling and occurs at the apical membrane of the thyrocytes.	Tyrosine	85-93	thyroglobulin	Homo sapiens	0-13
8530385-2	1995	Thyroglobulin (Tg) is the substrate for thyroid hormone biosynthesis, which requires tyrosine iodination and iodotyrosine coupling and occurs at the apical membrane of the thyrocytes.	Monoiodotyrosine	109-121	thyroglobulin	Homo sapiens	0-13
7549998-7	1994	In another subject, molecular studies revealed that exon 4 was missing from the major Tg transcript due to a cytosine to guanine transversion at position minus 3 in the acceptor splice site of intron 3.	Cytosine	109-117	thyroglobulin	Homo sapiens	86-88
7852510-3	1995	Thyroglobulin (Tg), the only iodoprotein found, had a normal monomer size (330 kilodaltons), but low content of hormone and iodine.	Iodine	124-130	thyroglobulin	Homo sapiens	0-13
7852510-3	1995	Thyroglobulin (Tg), the only iodoprotein found, had a normal monomer size (330 kilodaltons), but low content of hormone and iodine.	Iodine	124-130	thyroglobulin	Homo sapiens	15-17
7487672-2	1995	Changes in morphological characteristics and production of Tg, T3, and T4 induced by addition of thyroid stimulating hormone (TSH) to medium in collagen gel culture were also determined.	Thyrotropin	97-124	thyroglobulin	Homo sapiens	59-61
7487672-2	1995	Changes in morphological characteristics and production of Tg, T3, and T4 induced by addition of thyroid stimulating hormone (TSH) to medium in collagen gel culture were also determined.	Thyrotropin	126-129	thyroglobulin	Homo sapiens	59-61
7487672-6	1995	Only for normal thyroid cells did addition of TSH to medium induce increase the percentage of colonies producing Tg or T4 and morphological changes including an enlarged follicular lumen and increase in the height of columnar epithelium.	Thyrotropin	46-49	thyroglobulin	Homo sapiens	113-115
7822419-1	1995	Before secretion, newly synthesized thyroglobulin (Tg) folds via a series of intermediates: disulfide-linked aggregates and unfolded monomers--&gt;folded monomers--&gt;dimers.	Disulfides	92-101	thyroglobulin	Homo sapiens	36-49
7527742-0	1994	Tryptic peptides of human thyroglobulin: I. Immunoreactivity with murine monoclonal antibodies.	Peptides	8-16	thyroglobulin	Homo sapiens	26-39
7527743-0	1994	Tryptic peptides of human thyroglobulin: II.	Peptides	8-16	thyroglobulin	Homo sapiens	26-39
7527743-2	1994	Tryptic peptides of human thyroglobulin (Tg) were analysed by Western immunoblot for their reactivity to circulating autoantibodies from patients with Hashimoto"s thyroiditis (HT), Graves" disease (GD) and thyroid carcinoma, and from normal human controls.	Peptides	8-16	thyroglobulin	Homo sapiens	26-39
7549998-7	1994	In another subject, molecular studies revealed that exon 4 was missing from the major Tg transcript due to a cytosine to guanine transversion at position minus 3 in the acceptor splice site of intron 3.	Guanine	121-128	thyroglobulin	Homo sapiens	86-88
7952156-6	1994	In 28 patients with subnormal TSH, a normal TG value had a predictive value of 0.6 to exclude autonomous thyroid function.	Thyrotropin	30-33	thyroglobulin	Homo sapiens	44-46
7944754-5	1994	The data demonstrated a transient rise in the free thyroxine level associated with and followed by significant reductions in the free and total triiodothyronine, total thyroxine, thyroid-stimulating hormone, and thyroglobulin levels in the early postoperative period.	Thyroxine	51-60	thyroglobulin	Homo sapiens	212-225
8075781-0	1994	Effect of thyroxine administration on serum thyrotropin receptor antibody and thyroglobulin levels in patients with Graves" hyperthyroidism during antithyroid drug therapy.	Thyroxine	10-19	thyroglobulin	Homo sapiens	78-91
7925119-8	1994	This was confirmed by an analysis of the iodoamino acids of thyroglobulin, cathepsin-D (representing a secretory protein), and aminopeptidase-N (a membrane-integrated protein) by two-dimensional TLC, which revealed the presence of T3 and T4 only within the polypeptide chain of thyroglobulin.	iodoamino acids	41-56	thyroglobulin	Homo sapiens	60-73
7833657-0	1994	Effect of postoperative 131I treatment on thyroglobulin measurements in the follow-up of patients with thyroid cancer.	Iodine-131	24-28	thyroglobulin	Homo sapiens	42-55
8075781-3	1994	We therefore observed the changes of serum TR-ab, thyroglobulin (Tg) and thyroid hormone levels in response to administration of L-thyroxine (T4) in Graves" hyperthyroid patients during antithyroid drug therapy.	Thyroxine	129-140	thyroglobulin	Homo sapiens	50-63
8040191-12	1994	TSH effect and insulin effect on the incorporation of 3H-mannose into thyroglobulin as well as on the anionic residue content of the molecule were additive.	alpha-D-Mannose	54-64	thyroglobulin	Homo sapiens	70-83
7920005-0	1994	Radioiodine uptake as a function of stored iodine and thyroglobulin in thyroid follicles: in vitro quantitative imaging approach with secondary ion mass spectrometry (SIMS) microscopy in human nontoxic goiter.	Iodine-131	0-11	thyroglobulin	Homo sapiens	54-67
8020185-1	1994	Human thyroglobulin (Tg) was purified from thyroids of normal individuals and of patients with Graves" disease using gel filtration (Sephacryl S-400) and ion-exchange (DEAE) column chromatography.	sephacryl s-400	133-148	thyroglobulin	Homo sapiens	6-24
8020185-1	1994	Human thyroglobulin (Tg) was purified from thyroids of normal individuals and of patients with Graves" disease using gel filtration (Sephacryl S-400) and ion-exchange (DEAE) column chromatography.	2-diethylaminoethanol	168-172	thyroglobulin	Homo sapiens	6-24
8020185-2	1994	We isolated five protein peaks of Tg from the DEAE column, using a step gradient, characterized them for protein and iodine content, and assessed their immunological properties by reactivity to polyclonal and monoclonal antibodies (mAbs).	2-diethylaminoethanol	46-50	thyroglobulin	Homo sapiens	34-36
8020185-10	1994	The immunoreactivity of this mAb paralleled the iodine content of Tg.	Iodine	48-54	thyroglobulin	Homo sapiens	66-68
8020185-11	1994	This mAb might be useful for evaluating the role of iodine in the antigenicity of human Tg.	Iodine	52-58	thyroglobulin	Homo sapiens	88-90
8294995-7	1994	CONCLUSION: In patients treated with 131I, serum thyroglobulin assay was an excellent method to assess treatment.	Iodine-131	37-41	thyroglobulin	Homo sapiens	49-62
8137731-0	1994	Glycosylation of thyroglobulin secreted by porcine cells cultured in chamber system: thyrotropin controls the number of oligosaccharides and their anionic residues.	Oligosaccharides	120-136	thyroglobulin	Homo sapiens	17-30
8137731-2	1994	Radiolabeled-sugar (3H-mannose) was added to the basal medium on day 11 for 4 days and the glycosylation of thyroglobulin (Tg), the major glycoprotein secreted into the apical medium, was studied.	Sugars	12-18	thyroglobulin	Homo sapiens	108-121
8137731-3	1994	The incorporation of 3H-mannose per molecule of Tg was increased 1.5-fold by a 50 microU/ml minimal concentration of TSH.	alpha-D-Mannose	21-31	thyroglobulin	Homo sapiens	48-50
8137731-3	1994	The incorporation of 3H-mannose per molecule of Tg was increased 1.5-fold by a 50 microU/ml minimal concentration of TSH.	Thyrotropin	117-120	thyroglobulin	Homo sapiens	48-50
8126160-11	1994	Serum thyroglobulin levels markedly increased 3 h after ethanol injection.	Ethanol	56-63	thyroglobulin	Homo sapiens	6-19
7511888-0	1994	[Chemical iodination of hormonogenic tyrosine residues of human thyroglobulin is critical for the production of anti-thyroglobulin autoantibody and for the induction of experimental autoimmune thyroiditis in mice].	Tyrosine	37-45	thyroglobulin	Homo sapiens	64-77
7511888-0	1994	[Chemical iodination of hormonogenic tyrosine residues of human thyroglobulin is critical for the production of anti-thyroglobulin autoantibody and for the induction of experimental autoimmune thyroiditis in mice].	Tyrosine	37-45	thyroglobulin	Homo sapiens	117-130
8299583-0	1994	The number of oligosaccharides borne by porcine thyroglobulin is variable.	Oligosaccharides	14-30	thyroglobulin	Homo sapiens	48-61
8196170-3	1994	The results support the hypothesis that the increase in the diiodotyrosine residue in thyroglobulin inhibits further iodination by switching the catalytic cycle to oxidative coupling, to form thyroid hormones.	Diiodotyrosine	60-74	thyroglobulin	Homo sapiens	86-99
8196172-1	1994	The thyroglobulin (Tg) gene is a 300-kilobase (kb) single copy gene, containing at least 42 exons, mapped in man to chromosome 8 (8q24) and codes for a glycoprotein with a molecular weight 660,000, which functions as a matrix for the thyroid hormone (T4, T3) and iodothyronine synthesis.	iodothyronine	263-276	thyroglobulin	Homo sapiens	4-17
8196172-1	1994	The thyroglobulin (Tg) gene is a 300-kilobase (kb) single copy gene, containing at least 42 exons, mapped in man to chromosome 8 (8q24) and codes for a glycoprotein with a molecular weight 660,000, which functions as a matrix for the thyroid hormone (T4, T3) and iodothyronine synthesis.	iodothyronine	263-276	thyroglobulin	Homo sapiens	19-21
8031964-0	1994	Thyroglobulin is a more sensitive indicator of iodine deficiency than thyrotropin: development and evaluation of dry blood spot assays for thyrotropin and thyroglobulin in iodine-deficient geographical areas.	Iodine	47-53	thyroglobulin	Homo sapiens	0-13
8031964-9	1994	The results showed that serum thyroglobulin levels are a more sensitive indicator of iodine deficiency than thyrotropin; elevated thyroglobulin levels were found in 182/304 children in Zimbabwe compared with elevated thyrotropin level in 28/304 cases.	Iodine	85-91	thyroglobulin	Homo sapiens	30-43
8138749-11	1994	Total non-thyroglobulin-iodine, the only fraction comprising possible cell growth-regulating iodo-compounds, varied by a factor of &gt; 60 between different goitres and by a factor of &gt; 6 between different samples of the same goitre.	Iodine	24-30	thyroglobulin	Homo sapiens	10-23
8138749-8	1994	Total iodine concentration, as well as its sub-fractions, i.e. thyroglobulin-iodine and non-thyroglobulin-iodine, were significantly lower than in normal thyroids.	Iodine	77-83	thyroglobulin	Homo sapiens	63-76
8490927-12	1993	Thallium-201 scintigraphy was especially useful in cases in which iodine-131 scintigraphy was negative and quantitative thyroglobulin levels were elevated.	Thallium	0-8	thyroglobulin	Homo sapiens	120-133
8138749-8	1994	Total iodine concentration, as well as its sub-fractions, i.e. thyroglobulin-iodine and non-thyroglobulin-iodine, were significantly lower than in normal thyroids.	Iodine	77-83	thyroglobulin	Homo sapiens	63-76
8325944-0	1993	A nonsense mutation causes human hereditary congenital goiter with preferential production of a 171-nucleotide-deleted thyroglobulin ribonucleic acid messenger.	171-nucleotide	96-110	thyroglobulin	Homo sapiens	119-132
8325944-5	1993	The Tg mRNA from normal and goitrous thyroid tissue was first reverse transcribed and divided into five overlapping portions from positions 57-8448, and the resulting cDNAs were amplified by polymerase chain reaction and analyzed by agarose gel electrophoresis.	Sepharose	233-240	thyroglobulin	Homo sapiens	4-6
8132699-1	1994	7-Hydroxycoumarin (7-HC) was chemically conjugated by diazo coupling to carrier proteins such as bovine serum albumin (BSA), thyroglobulin and ovalbumin.	7-hydroxycoumarin	0-17	thyroglobulin	Homo sapiens	104-152
8132699-1	1994	7-Hydroxycoumarin (7-HC) was chemically conjugated by diazo coupling to carrier proteins such as bovine serum albumin (BSA), thyroglobulin and ovalbumin.	7-hydroxycoumarin	19-23	thyroglobulin	Homo sapiens	104-152
8132699-1	1994	7-Hydroxycoumarin (7-HC) was chemically conjugated by diazo coupling to carrier proteins such as bovine serum albumin (BSA), thyroglobulin and ovalbumin.	diazo	54-59	thyroglobulin	Homo sapiens	104-152
8269951-10	1993	Most cleavage sites occurred within the inserted sequences that disrupt the Cys-rich, tandem repeats of thyroglobulin and either contain or are located near exon-intron junctions.	Cysteine	76-79	thyroglobulin	Homo sapiens	104-117
7522534-0	1993	Iodine induced splitting of peptide bonds in human thyroglobulin.	Iodine	0-6	thyroglobulin	Homo sapiens	51-64
7522534-1	1993	Human thyroglobulin pretreated with iodine (1mM) at alkaline pH is split to small molecular weight fragments after reduction with dithiothreitol.	Iodine	36-42	thyroglobulin	Homo sapiens	6-19
7522534-1	1993	Human thyroglobulin pretreated with iodine (1mM) at alkaline pH is split to small molecular weight fragments after reduction with dithiothreitol.	Dithiothreitol	130-144	thyroglobulin	Homo sapiens	6-19
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	metaperiodate	34-43	thyroglobulin	Homo sapiens	14-16
8504765-1	1993	Thyroglobulin (Tg) molecules stored in thyroid follicle lumens are heterogeneous in terms of iodine and hormone contents.	Iodine	93-99	thyroglobulin	Homo sapiens	0-13
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	metaperiodate	34-43	thyroglobulin	Homo sapiens	126-128
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	metaperiodate	34-43	thyroglobulin	Homo sapiens	126-128
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	Dithiothreitol	45-59	thyroglobulin	Homo sapiens	14-16
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	Dithiothreitol	45-59	thyroglobulin	Homo sapiens	126-128
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	Dithiothreitol	45-59	thyroglobulin	Homo sapiens	126-128
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	Dithiothreitol	61-64	thyroglobulin	Homo sapiens	14-16
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	Dithiothreitol	61-64	thyroglobulin	Homo sapiens	126-128
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	Dithiothreitol	61-64	thyroglobulin	Homo sapiens	126-128
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	Sodium Dodecyl Sulfate	70-92	thyroglobulin	Homo sapiens	14-16
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	Sodium Dodecyl Sulfate	70-92	thyroglobulin	Homo sapiens	126-128
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	Sodium Dodecyl Sulfate	70-92	thyroglobulin	Homo sapiens	126-128
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	Sodium Dodecyl Sulfate	94-97	thyroglobulin	Homo sapiens	14-16
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	Sodium Dodecyl Sulfate	94-97	thyroglobulin	Homo sapiens	126-128
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	Sodium Dodecyl Sulfate	94-97	thyroglobulin	Homo sapiens	126-128
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	Dithiothreitol	199-202	thyroglobulin	Homo sapiens	14-16
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	Dithiothreitol	199-202	thyroglobulin	Homo sapiens	126-128
7688705-3	1993	When purified Tg was treated with periodate, dithiothreitol (DTT) and sodium dodecyl sulfate (SDS), immunoblotting of treated Tg with TCM-9 revealed an apparent enhancement of the staining only with DTT-treated Tg.	Dithiothreitol	199-202	thyroglobulin	Homo sapiens	126-128
7688705-4	1993	Furthermore, the DTT-treated Tg was shown to bind dose-dependently to plates coated with TCM-9.	Dithiothreitol	17-20	thyroglobulin	Homo sapiens	29-31
7688705-4	1993	Furthermore, the DTT-treated Tg was shown to bind dose-dependently to plates coated with TCM-9.	tcm-9	89-94	thyroglobulin	Homo sapiens	29-31
8099828-0	1993	Efficacy of thyroxine-suppressive therapy and its relation to serum thyroglobulin levels in solitary nontoxic thyroid nodules.	Thyroxine	12-21	thyroglobulin	Homo sapiens	68-81
8094490-4	1993	DNA sequencing showed a mis-sense mutation within thyroglobulin gene exon 10, resulting in a glutamine to histidine substitution.	Glutamine	93-102	thyroglobulin	Homo sapiens	50-63
8094490-4	1993	DNA sequencing showed a mis-sense mutation within thyroglobulin gene exon 10, resulting in a glutamine to histidine substitution.	Histidine	106-115	thyroglobulin	Homo sapiens	50-63
8212961-0	1993	Iodine induced alteration in immunological and biochemical properties of thyroglobulin.	Iodine	0-6	thyroglobulin	Homo sapiens	73-86
8212961-1	1993	The influence of iodine-iodide solution on the biochemical and immunological properties of human thyroglobulin (hTg) were studied.	Iodine	17-30	thyroglobulin	Homo sapiens	97-110
8463554-0	1993	Retinoic acid inhibits human thyroid peroxidase and thyroglobulin gene expression in cultured human thyrocytes.	Tretinoin	0-13	thyroglobulin	Homo sapiens	52-65
8463554-1	1993	The effect of retinoic acid (RA) on thyroid peroxidase (TPO) and thyroglobulin (Tg) gene expression was investigated in cultured human thyrocytes.	Tretinoin	14-27	thyroglobulin	Homo sapiens	80-82
8463554-1	1993	The effect of retinoic acid (RA) on thyroid peroxidase (TPO) and thyroglobulin (Tg) gene expression was investigated in cultured human thyrocytes.	Tretinoin	29-31	thyroglobulin	Homo sapiens	65-78
8463554-5	1993	Furthermore, RA inhibited forskolin and 8-Bromo-cyclic-AMP-induced TPO and Tg gene expression, suggesting a distal action site for these cAMP mediated gene expressions.	Tretinoin	13-15	thyroglobulin	Homo sapiens	75-77
8463554-5	1993	Furthermore, RA inhibited forskolin and 8-Bromo-cyclic-AMP-induced TPO and Tg gene expression, suggesting a distal action site for these cAMP mediated gene expressions.	Colforsin	26-35	thyroglobulin	Homo sapiens	75-77
8463554-5	1993	Furthermore, RA inhibited forskolin and 8-Bromo-cyclic-AMP-induced TPO and Tg gene expression, suggesting a distal action site for these cAMP mediated gene expressions.	8-Bromo Cyclic Adenosine Monophosphate	40-58	thyroglobulin	Homo sapiens	75-77
8463554-5	1993	Furthermore, RA inhibited forskolin and 8-Bromo-cyclic-AMP-induced TPO and Tg gene expression, suggesting a distal action site for these cAMP mediated gene expressions.	Cyclic AMP	137-141	thyroglobulin	Homo sapiens	75-77
8463554-9	1993	RA also inhibited TSH-induced Tg secretion in a dose dependent manner.	Tretinoin	0-2	thyroglobulin	Homo sapiens	30-32
8463554-11	1993	In conclusion, RA inhibits the synthesis of TPO and Tg via the suppression of thyroid-specific gene expression although the exact site of RA action on these genes in human thyroids remains to be further elucidated.	Tretinoin	15-17	thyroglobulin	Homo sapiens	52-54
8463554-12	1993	These results suggest that RA may play a regulatory role in Tg and TPO gene expression, subsequently resulting in the suppression of thyroid hormone synthesis.	Tretinoin	27-29	thyroglobulin	Homo sapiens	60-62
1446629-3	1992	This iodinated thyroglobulin contained thyroid hormones (T3 + T4) which involved 22.7% of the thyroglobulin iodine content.	Iodine	108-114	thyroglobulin	Homo sapiens	94-107
20732175-5	1993	DMSO also partially or totally abolished the inhibition of cyclic AMP (cAMP), thyroglobulin (Tg) and triiodothyronine (T(3)) production observed with 7.5, 15 or 30 mum-cisplatin.	Dimethyl Sulfoxide	0-4	thyroglobulin	Homo sapiens	78-91
20732175-5	1993	DMSO also partially or totally abolished the inhibition of cyclic AMP (cAMP), thyroglobulin (Tg) and triiodothyronine (T(3)) production observed with 7.5, 15 or 30 mum-cisplatin.	Dimethyl Sulfoxide	0-4	thyroglobulin	Homo sapiens	93-95
20732175-5	1993	DMSO also partially or totally abolished the inhibition of cyclic AMP (cAMP), thyroglobulin (Tg) and triiodothyronine (T(3)) production observed with 7.5, 15 or 30 mum-cisplatin.	Cisplatin	168-177	thyroglobulin	Homo sapiens	78-91
20732175-6	1993	In the presence of 75 mum-cisplatin, cAMP, Tg and T(3) secretion was always totally inhibited.	Cisplatin	26-35	thyroglobulin	Homo sapiens	43-45
1446629-2	1992	The long-term iodination of thyroglobulin secreted into the apical medium of thyroid cells cultured as monolayers on porous bottom chambers reached 5.87 +/- 1.66 atoms of iodine/mol thyroglobulin after 11 days incubation in the presence of TSH (0.1 mU/ml) and iodide (0.5 microM) in the basal medium.	Iodine	171-177	thyroglobulin	Homo sapiens	28-41
1446629-2	1992	The long-term iodination of thyroglobulin secreted into the apical medium of thyroid cells cultured as monolayers on porous bottom chambers reached 5.87 +/- 1.66 atoms of iodine/mol thyroglobulin after 11 days incubation in the presence of TSH (0.1 mU/ml) and iodide (0.5 microM) in the basal medium.	Thyrotropin	240-243	thyroglobulin	Homo sapiens	28-41
1446629-2	1992	The long-term iodination of thyroglobulin secreted into the apical medium of thyroid cells cultured as monolayers on porous bottom chambers reached 5.87 +/- 1.66 atoms of iodine/mol thyroglobulin after 11 days incubation in the presence of TSH (0.1 mU/ml) and iodide (0.5 microM) in the basal medium.	Iodides	260-266	thyroglobulin	Homo sapiens	28-41
1446629-3	1992	This iodinated thyroglobulin contained thyroid hormones (T3 + T4) which involved 22.7% of the thyroglobulin iodine content.	Iodine	108-114	thyroglobulin	Homo sapiens	15-28
1446629-9	1992	Our culture system makes it possible to demonstrate that this high iodide concentration in the basal medium did not increase apical iodide concentration above 10 microM but decreased apical thyroglobulin concentration.	Iodides	67-73	thyroglobulin	Homo sapiens	190-203
1446629-10	1992	The inhibitory effect of iodide on hormonogenesis cannot be due to a competition with tyrosine residues of thyroglobulin for their binding to thyroperoxidase although it could be related, at least in part, to a decrease in protein synthesis.	Tyrosine	86-94	thyroglobulin	Homo sapiens	107-120
1353499-3	1992	During the first 15 min after biosynthesis, Tg is found in transient aggregates with and without interchain disulfide bonds, which precede the formation of free monomers (and ultimately dimers) within the ER.	Disulfides	108-117	thyroglobulin	Homo sapiens	44-46
1281126-0	1992	Tyrosine iodination and iodotyrosyl coupling of the N-terminal thyroid hormone forming site of human thyroglobulin modulate its binding to auto- and monoclonal antibodies.	Tyrosine	0-8	thyroglobulin	Homo sapiens	101-114
1281126-0	1992	Tyrosine iodination and iodotyrosyl coupling of the N-terminal thyroid hormone forming site of human thyroglobulin modulate its binding to auto- and monoclonal antibodies.	iodotyrosyl	24-35	thyroglobulin	Homo sapiens	101-114
1328820-0	1992	Early adaptation of thyrotropin and thyroglobulin secretion to experimentally decreased iodine supply in man.	Iodine	88-94	thyroglobulin	Homo sapiens	36-49
1517370-12	1992	The TSH and TG alterations at birth in full-term healthy newborns, associated with similar alterations in maternal thyroid function, provide evidence for a common stimulatory factor, relative iodine deficiency.	Iodine	192-198	thyroglobulin	Homo sapiens	12-14
1510654-1	1992	Bovine and human thyroglobulin show two closely migrating bands in reducing SDS-PAGE.	Sodium Dodecyl Sulfate	76-79	thyroglobulin	Homo sapiens	17-30
1396689-4	1992	Porcine thyroglobulin was shown to carry the mannose 6-phosphate-(Man6P)-recognition marker on its N-linked glycans.	mannose-6-phosphate	45-64	thyroglobulin	Homo sapiens	8-21
1396689-4	1992	Porcine thyroglobulin was shown to carry the mannose 6-phosphate-(Man6P)-recognition marker on its N-linked glycans.	alpha-D-mannose 6-phosphate	66-71	thyroglobulin	Homo sapiens	8-21
1396689-4	1992	Porcine thyroglobulin was shown to carry the mannose 6-phosphate-(Man6P)-recognition marker on its N-linked glycans.	n-linked glycans	99-115	thyroglobulin	Homo sapiens	8-21
1357069-3	1992	The results show that suramin, at concentrations similar to serum levels obtainable during therapy, inhibited the proliferation of thyroid cells as well as the secretion of thyroglobulin.	Suramin	22-29	thyroglobulin	Homo sapiens	173-186
1397386-4	1992	The iodine content of Tg was significantly lower in the non-functioning tumor than in peripheral tissues.	Iodine	4-10	thyroglobulin	Homo sapiens	22-24
1397386-5	1992	Affinity with Lectins differed among Tg preparations, suggesting that the carbohydrate chain in the Tg was different in each nodule in a single individual.	Carbohydrates	74-86	thyroglobulin	Homo sapiens	37-39
1397386-5	1992	Affinity with Lectins differed among Tg preparations, suggesting that the carbohydrate chain in the Tg was different in each nodule in a single individual.	Carbohydrates	74-86	thyroglobulin	Homo sapiens	100-102
1353499-5	1992	Much of the Tg released from BiP by the addition of Mg-ATP was found in aggregates containing interchain disulfide bonds; other BiP-associated Tg represented non-covalent aggregates and unfolded free monomers.	Adenosine Triphosphate	52-58	thyroglobulin	Homo sapiens	12-14
1353499-5	1992	Much of the Tg released from BiP by the addition of Mg-ATP was found in aggregates containing interchain disulfide bonds; other BiP-associated Tg represented non-covalent aggregates and unfolded free monomers.	Disulfides	105-114	thyroglobulin	Homo sapiens	12-14
1353499-8	1992	Cycloheximide was used to reduced the ER concentration of Tg relative to chaperones, with subsequent removal of the drug in order to rapidly restore Tg synthesis.	Cycloheximide	0-13	thyroglobulin	Homo sapiens	58-60
1353499-8	1992	Cycloheximide was used to reduced the ER concentration of Tg relative to chaperones, with subsequent removal of the drug in order to rapidly restore Tg synthesis.	Cycloheximide	0-13	thyroglobulin	Homo sapiens	149-151
1321636-3	1992	After 72 h in culture, different concentrations of cisplatin (15, 30 and 75 microM) caused partial or total inhibition of cyclic AMP (cAMP), thyroglobulin (Tg) and tri-iodothyronine (T3) production, whereas thyroxine levels increased in the medium of thyrocytes cultured as follicles.	Cisplatin	51-60	thyroglobulin	Homo sapiens	141-154
1446262-5	1992	A major polarized secretion of thyroglobulin into the apical compartment was observed; it was increased in the presence of TSH as well as the thyroglobulin synthesis and mRNA level.	Thyrotropin	123-126	thyroglobulin	Homo sapiens	31-44
1446262-9	1992	In the culture chamber system, thyroglobulin was weakly iodinated (6 atoms of iodide per mole of thyroglobulin; in vivo up to 40 atoms per mole) but hormonogenesis efficiency was close to this one observed in vivo (40%).	Iodides	78-84	thyroglobulin	Homo sapiens	31-44
1446262-10	1992	Iodide concentrations higher than 0.5 microM daily added to the basal medium inhibited iodination of thyroglobulin and hormonosynthesis.	Iodides	0-6	thyroglobulin	Homo sapiens	101-114
1321636-3	1992	After 72 h in culture, different concentrations of cisplatin (15, 30 and 75 microM) caused partial or total inhibition of cyclic AMP (cAMP), thyroglobulin (Tg) and tri-iodothyronine (T3) production, whereas thyroxine levels increased in the medium of thyrocytes cultured as follicles.	Cisplatin	51-60	thyroglobulin	Homo sapiens	156-158
1321636-7	1992	Cisplatin also induced inhibition of the production of cAMP, Tg and T3.	Cisplatin	0-9	thyroglobulin	Homo sapiens	61-63
1575301-2	1992	The use of iodine 131 (131I) ablation as adjuvant therapy may facilitate follow-up of patients in whom serum thyroglobulin levels and 131I total body scans are used to detect metastatic disease.	Iodine-131	11-21	thyroglobulin	Homo sapiens	109-122
1575301-2	1992	The use of iodine 131 (131I) ablation as adjuvant therapy may facilitate follow-up of patients in whom serum thyroglobulin levels and 131I total body scans are used to detect metastatic disease.	Iodine-131	23-27	thyroglobulin	Homo sapiens	109-122
1534524-6	1992	The highest antibody titres against gentamicin found by the ELISA method were obtained when procedures were used where the carrier was serum albumin and thyroglobulin and as adjuvant complete Freund adjuvant was used.	Gentamicins	36-46	thyroglobulin	Homo sapiens	153-166
1628693-0	1992	Serum thyroglobulin level in patients with diffuse and nodular goiter, after therapeutic application of stable iodine.	Iodine	111-117	thyroglobulin	Homo sapiens	6-19
1370485-0	1992	Modulation of the carbohydrate moiety of thyroglobulin by thyrotropin and calcium in Fisher rat thyroid line-5 cells.	Carbohydrates	18-30	thyroglobulin	Homo sapiens	41-54
1370485-0	1992	Modulation of the carbohydrate moiety of thyroglobulin by thyrotropin and calcium in Fisher rat thyroid line-5 cells.	Calcium	74-81	thyroglobulin	Homo sapiens	41-54
1370485-1	1992	Thyroglobulin secreted in the medium by Fisher rat thyroid line-5 (FRTL-5) cells cultured in the presence of thyroid stimulating hormone (TSH) shows a slower electrophoretic mobility in sodium dodecyl sulfate-polyacrylamide gel electrophoresis and a higher density position in a CsCl gradient than thyroglobulin secreted by FRTL-5 cells cultured in the absence of TSH for 5-7 days.	Thyrotropin	109-136	thyroglobulin	Homo sapiens	0-13
1370485-1	1992	Thyroglobulin secreted in the medium by Fisher rat thyroid line-5 (FRTL-5) cells cultured in the presence of thyroid stimulating hormone (TSH) shows a slower electrophoretic mobility in sodium dodecyl sulfate-polyacrylamide gel electrophoresis and a higher density position in a CsCl gradient than thyroglobulin secreted by FRTL-5 cells cultured in the absence of TSH for 5-7 days.	Thyrotropin	138-141	thyroglobulin	Homo sapiens	0-13
1370485-1	1992	Thyroglobulin secreted in the medium by Fisher rat thyroid line-5 (FRTL-5) cells cultured in the presence of thyroid stimulating hormone (TSH) shows a slower electrophoretic mobility in sodium dodecyl sulfate-polyacrylamide gel electrophoresis and a higher density position in a CsCl gradient than thyroglobulin secreted by FRTL-5 cells cultured in the absence of TSH for 5-7 days.	Sodium Dodecyl Sulfate	186-208	thyroglobulin	Homo sapiens	0-13
1370485-1	1992	Thyroglobulin secreted in the medium by Fisher rat thyroid line-5 (FRTL-5) cells cultured in the presence of thyroid stimulating hormone (TSH) shows a slower electrophoretic mobility in sodium dodecyl sulfate-polyacrylamide gel electrophoresis and a higher density position in a CsCl gradient than thyroglobulin secreted by FRTL-5 cells cultured in the absence of TSH for 5-7 days.	polyacrylamide	209-223	thyroglobulin	Homo sapiens	0-13
1370485-1	1992	Thyroglobulin secreted in the medium by Fisher rat thyroid line-5 (FRTL-5) cells cultured in the presence of thyroid stimulating hormone (TSH) shows a slower electrophoretic mobility in sodium dodecyl sulfate-polyacrylamide gel electrophoresis and a higher density position in a CsCl gradient than thyroglobulin secreted by FRTL-5 cells cultured in the absence of TSH for 5-7 days.	Thyrotropin	364-367	thyroglobulin	Homo sapiens	0-13
1391595-0	1992	Analysis of carbohydrate residues on human thyroid peroxidase (TPO) and thyroglobulin (Tg) and effects of deglycosylation, reduction and unfolding on autoantibody binding.	Carbohydrates	12-24	thyroglobulin	Homo sapiens	72-85
1420807-4	1992	(1) T and/or B cells may react specifically to iodinated portions of thyroglobulin (Tg) so that severe iodine depletion renders Tg non-immunogenic.	Iodine	103-109	thyroglobulin	Homo sapiens	69-82
1628693-3	1992	Prior to the therapy females had elevated thyroglobulin serum concentrations, caused by existence of diffuse and nodular goiter, which reflected an increase in intraglandular turnover of thyroglobulin (192 +/- 140 mcg/L in GROUP A further treated with Thyral and 121 +/- 14.80 +/- mcg/L in GROUP B, whose patients received Vobenol, mean +/- SD).	vobenol	323-330	thyroglobulin	Homo sapiens	187-200
1752339-6	1991	The iodination level of cancer Tg with a very low iodine content (less than 0.1%) was low compared with the normal Tg level (obtained from normal thyroid tissue which contained about 0.4% iodine).	Iodine	50-56	thyroglobulin	Homo sapiens	31-33
1727828-4	1992	Gel electrophoresis in a 7.5% sodium dodecyl sulfate-polyacrylamide gel revealed a major band with the same mobility and immunoreactivity as normal 19S Tg.	Sodium Dodecyl Sulfate	30-52	thyroglobulin	Homo sapiens	152-154
1727828-4	1992	Gel electrophoresis in a 7.5% sodium dodecyl sulfate-polyacrylamide gel revealed a major band with the same mobility and immunoreactivity as normal 19S Tg.	polyacrylamide	53-67	thyroglobulin	Homo sapiens	152-154
1727828-5	1992	Hydrolysis of the patient"s Tg indicated that most of the radioactivity was mono- and diiodotyrosines.	mono- and diiodotyrosines	76-101	thyroglobulin	Homo sapiens	28-30
1727828-11	1992	We conclude that the finding of severely hyposialylated Tg is linked to a defect in iodotyrosine coupling seen in this patient with a possibly abnormal migration of Tg into the follicular lumen.	Monoiodotyrosine	84-96	thyroglobulin	Homo sapiens	56-58
1727828-11	1992	We conclude that the finding of severely hyposialylated Tg is linked to a defect in iodotyrosine coupling seen in this patient with a possibly abnormal migration of Tg into the follicular lumen.	Monoiodotyrosine	84-96	thyroglobulin	Homo sapiens	165-167
1493370-3	1992	We have investigated whether a palmitate conjugate of a human monoclonal antibody specific for thyroglobulin (TG) could function as a surrogate TG receptor on blood mononuclear cells separated into fractions enriched for T cells or depleted of T cells (non-T cells).	Palmitates	31-40	thyroglobulin	Homo sapiens	95-108
1493370-3	1992	We have investigated whether a palmitate conjugate of a human monoclonal antibody specific for thyroglobulin (TG) could function as a surrogate TG receptor on blood mononuclear cells separated into fractions enriched for T cells or depleted of T cells (non-T cells).	Palmitates	31-40	thyroglobulin	Homo sapiens	110-112
1493370-3	1992	We have investigated whether a palmitate conjugate of a human monoclonal antibody specific for thyroglobulin (TG) could function as a surrogate TG receptor on blood mononuclear cells separated into fractions enriched for T cells or depleted of T cells (non-T cells).	Palmitates	31-40	thyroglobulin	Homo sapiens	144-146
1468508-2	1992	The regulation of single steps in this pathway is unclear, but a possible basis for this transport appeared to be the presence of the lysosomal targetting, signal mannose-6-phosphate (M6P), on porcine thyroglobulin and the detection of the cation-dependent M6P-receptor on the apical cell surface and the Golgi-complex in thyrocytes.	mannose-6-phosphate	163-182	thyroglobulin	Homo sapiens	201-214
1468508-2	1992	The regulation of single steps in this pathway is unclear, but a possible basis for this transport appeared to be the presence of the lysosomal targetting, signal mannose-6-phosphate (M6P), on porcine thyroglobulin and the detection of the cation-dependent M6P-receptor on the apical cell surface and the Golgi-complex in thyrocytes.	mannose-6-phosphate	184-187	thyroglobulin	Homo sapiens	201-214
1769134-10	1991	Moderate elevation of serum Tg may be due to inadequate thyroxine suppression therapy, assessed by detectable TSH values measured in a sensitive assay.	Thyrotropin	110-113	thyroglobulin	Homo sapiens	28-30
1959601-3	1991	Tyrosine 130 in the mammalian thyroglobulin molecule is known to be an iodination site.	Tyrosine	0-8	thyroglobulin	Homo sapiens	30-43
1752339-6	1991	The iodination level of cancer Tg with a very low iodine content (less than 0.1%) was low compared with the normal Tg level (obtained from normal thyroid tissue which contained about 0.4% iodine).	Iodine	188-194	thyroglobulin	Homo sapiens	31-33
1752339-9	1991	These results suggest that the changes of iodine and thyroid hormone contents of Tg by in vitro iodination, has no significant effect on the immunological property of Tg molecule.	Iodine	42-48	thyroglobulin	Homo sapiens	81-83
1914236-2	1991	Autoantibodies to the thyrotropin (TSH) receptor from these patients, which had been initially characterized by their ability to stimulate adenylate cyclase and inhibit the binding of radiolabelled TSH to thyroid membrane preparations, were studied for their effects on thyroglobulin and thyroid peroxidase mRNA levels.	Thyrotropin	35-38	thyroglobulin	Homo sapiens	270-283
1915100-3	1991	Tg, which accumulates into the newly formed intrafollicular lumen (IL), was pulse labeled with [125I]iodide.	[125i]iodide	95-107	thyroglobulin	Homo sapiens	0-2
1915100-4	1991	Basal or TSH-activated Tg internalization, i.e. transfer from IL to cells, was assessed by measuring [125I]Tg in the cells and the IL; the IL fraction was collected after selective opening of lumina by a short treatment of RTF in a calcium-free medium.	Thyrotropin	9-12	thyroglobulin	Homo sapiens	23-25
1915100-6	1991	TSH caused a very rapid increase in the cellular uptake of labeled Tg; the endocytic index increased by a factor of 4-8.	Thyrotropin	0-3	thyroglobulin	Homo sapiens	67-69
1915100-9	1991	At 20 as well as 37 C, the action of TSH on Tg endocytosis was concentration dependent in the range of 0.05-10 mU/ml.	Thyrotropin	37-40	thyroglobulin	Homo sapiens	44-46
1915100-11	1991	The labeled Tg content of purified coated vesicles varied with the temperature of the chase-incubation and was increased in TSH-treated RTF.	Thyrotropin	124-127	thyroglobulin	Homo sapiens	12-14
1686772-0	1991	Hormone formation in the isolated fragment 1-171 of human thyroglobulin involves the couple tyrosine 5 and tyrosine 130.	Tyrosine	92-100	thyroglobulin	Homo sapiens	58-71
1686772-0	1991	Hormone formation in the isolated fragment 1-171 of human thyroglobulin involves the couple tyrosine 5 and tyrosine 130.	Tyrosine	107-115	thyroglobulin	Homo sapiens	58-71
1686772-1	1991	The 22 kDa fragment (Asn1-Met171) purified from iodine-poor human thyroglobulin (hTg) is capable by itself to synthesize thyroxine at Tyr5, the preferential hormonogenic acceptor site of the protein, after iodination in vitro.	Iodine	48-54	thyroglobulin	Homo sapiens	66-79
1686772-1	1991	The 22 kDa fragment (Asn1-Met171) purified from iodine-poor human thyroglobulin (hTg) is capable by itself to synthesize thyroxine at Tyr5, the preferential hormonogenic acceptor site of the protein, after iodination in vitro.	Thyroxine	121-130	thyroglobulin	Homo sapiens	66-79
1713250-0	1991	Identification of a thyroxine-containing self-epitope of thyroglobulin which triggers thyroid autoreactive T cells.	Thyroxine	20-29	thyroglobulin	Homo sapiens	57-70
1713250-3	1991	In vitro iodination of a Tg preparation which was deficient in in vivo organified iodine was first used to confirm our previous observation that these T cells recognize iodination-related epitopes in the Tg molecule.	Iodine	82-88	thyroglobulin	Homo sapiens	25-27
1713250-3	1991	In vitro iodination of a Tg preparation which was deficient in in vivo organified iodine was first used to confirm our previous observation that these T cells recognize iodination-related epitopes in the Tg molecule.	Iodine	82-88	thyroglobulin	Homo sapiens	204-206
1713250-4	1991	Affinity chromatography of tryptic peptides derived from normally iodinated human Tg revealed that these epitopes were exclusively located in thyroxine (T4) containing peptides.	Peptides	35-43	thyroglobulin	Homo sapiens	82-84
1713250-4	1991	Affinity chromatography of tryptic peptides derived from normally iodinated human Tg revealed that these epitopes were exclusively located in thyroxine (T4) containing peptides.	Thyroxine	142-151	thyroglobulin	Homo sapiens	82-84
1713250-4	1991	Affinity chromatography of tryptic peptides derived from normally iodinated human Tg revealed that these epitopes were exclusively located in thyroxine (T4) containing peptides.	Peptides	168-176	thyroglobulin	Homo sapiens	82-84
1668616-6	1991	TNF had no effect on either basal or TSH-stimulated cAMP generation, but significantly blunted TSH-stimulated Tg secretion.	Thyrotropin	95-98	thyroglobulin	Homo sapiens	110-112
2061316-10	1991	Inhibition of N-linked glycosylation by tunicamycin causes a complete block in intracellular Tg transport by inducing the formation of biologically irreversible aggregates, suggesting that glycosylation of Tg serves to prevent denaturation of the secretory protein within the ER lumen.	Nitrogen	14-15	thyroglobulin	Homo sapiens	93-95
2061316-10	1991	Inhibition of N-linked glycosylation by tunicamycin causes a complete block in intracellular Tg transport by inducing the formation of biologically irreversible aggregates, suggesting that glycosylation of Tg serves to prevent denaturation of the secretory protein within the ER lumen.	Nitrogen	14-15	thyroglobulin	Homo sapiens	206-208
2061316-10	1991	Inhibition of N-linked glycosylation by tunicamycin causes a complete block in intracellular Tg transport by inducing the formation of biologically irreversible aggregates, suggesting that glycosylation of Tg serves to prevent denaturation of the secretory protein within the ER lumen.	Tunicamycin	40-51	thyroglobulin	Homo sapiens	93-95
1663879-1	1991	Methimazole (1-methyl-2-mercaptoimidazole; MMI) increases thyroglobulin mRNA and thyroid peroxidase mRNA concentration in human thyroid cells and in FRTL-5 cells.	Methimazole	0-11	thyroglobulin	Homo sapiens	58-71
1663879-1	1991	Methimazole (1-methyl-2-mercaptoimidazole; MMI) increases thyroglobulin mRNA and thyroid peroxidase mRNA concentration in human thyroid cells and in FRTL-5 cells.	Methimazole	13-41	thyroglobulin	Homo sapiens	58-71
1954313-0	1991	The influence of iodine on the immunological properties of thyroglobulin and its immunological complexes.	Iodine	17-23	thyroglobulin	Homo sapiens	59-72
1874483-3	1991	ATA occurrence in children after iodine prophylaxis could confirm the hypothesis that thyroglobulin immunity is higher after iodine intake.	Amitrole	0-3	thyroglobulin	Homo sapiens	86-99
1874483-3	1991	ATA occurrence in children after iodine prophylaxis could confirm the hypothesis that thyroglobulin immunity is higher after iodine intake.	Iodine	33-39	thyroglobulin	Homo sapiens	86-99
1874483-3	1991	ATA occurrence in children after iodine prophylaxis could confirm the hypothesis that thyroglobulin immunity is higher after iodine intake.	Iodine	125-131	thyroglobulin	Homo sapiens	86-99
2005453-5	1991	Twenty-nine percent of patients evaluated after 131I ablative therapy had elevated serum thyroglobulin levels and localized neck and chest abnormalities on 201TI scan that were not seen on 131I studies.	Iodine-131	48-52	thyroglobulin	Homo sapiens	89-102
1786970-2	1991	Since it is difficult to isolate sufficient thyroglobulin from serum samples, in vivo radioiodinated serum thyroglobulin obtained after radioiodine administration was used.	Iodine-131	136-147	thyroglobulin	Homo sapiens	107-120
1786970-5	1991	More than 95% of metastatic serum thyroglobulin could be bound to concanavalin-A sepharose and be eluted with 0.5 M alpha-methyl mannoside.	Sepharose	81-90	thyroglobulin	Homo sapiens	34-47
1786970-5	1991	More than 95% of metastatic serum thyroglobulin could be bound to concanavalin-A sepharose and be eluted with 0.5 M alpha-methyl mannoside.	methylmannoside	116-138	thyroglobulin	Homo sapiens	34-47
1786970-8	1991	The metastatic serum thyroglobulin from follicular carcinoma of the thyroid thus appears to be 19 S thyroglobulin with near normal concanavalin-A binding sugars but altered surface charges.	Sugars	154-160	thyroglobulin	Homo sapiens	21-34
1783567-2	1991	A quantitative immunocytochemical method is described for measuring intracellular thyroglobulin in human thyrocytes grown in monolayer, based on the imidazole-enhanced 3,3"-diaminobenzidine/peroxidase reaction.	imidazole	149-158	thyroglobulin	Homo sapiens	82-95
1783567-2	1991	A quantitative immunocytochemical method is described for measuring intracellular thyroglobulin in human thyrocytes grown in monolayer, based on the imidazole-enhanced 3,3"-diaminobenzidine/peroxidase reaction.	3,3'-Diaminobenzidine	168-189	thyroglobulin	Homo sapiens	82-95
1826473-6	1991	The results indicate that the method described in the paper is suitable for the preparation of the complex gentamicin--bovine serum albumin and gentamicin--thyroglobulin.	Gentamicins	107-117	thyroglobulin	Homo sapiens	156-169
1826473-6	1991	The results indicate that the method described in the paper is suitable for the preparation of the complex gentamicin--bovine serum albumin and gentamicin--thyroglobulin.	Gentamicins	144-154	thyroglobulin	Homo sapiens	156-169
1954313-3	1991	Human Tg coated to polystyrene plates, incubated for 30 min with iodine-iodide solution at concentration from 1 to 200 microM at pH 9.0 lost its ability to bind aAbs.	Polystyrenes	19-30	thyroglobulin	Homo sapiens	6-8
1954313-3	1991	Human Tg coated to polystyrene plates, incubated for 30 min with iodine-iodide solution at concentration from 1 to 200 microM at pH 9.0 lost its ability to bind aAbs.	Iodine	65-78	thyroglobulin	Homo sapiens	6-8
1954313-5	1991	Tg epitope inactivation induced by iodine depended on the buffer pH and the presence of carbonate ions.	Iodine	35-41	thyroglobulin	Homo sapiens	0-2
1954313-5	1991	Tg epitope inactivation induced by iodine depended on the buffer pH and the presence of carbonate ions.	Carbonates	88-97	thyroglobulin	Homo sapiens	0-2
1954313-6	1991	The binding of rabbit Tg-antibodies to iodine pretreated Tg was only slightly changed.	Iodine	39-45	thyroglobulin	Homo sapiens	22-24
1954313-6	1991	The binding of rabbit Tg-antibodies to iodine pretreated Tg was only slightly changed.	Iodine	39-45	thyroglobulin	Homo sapiens	57-59
1954313-7	1991	Thyroglobulin preincubation with iodine solutions decreased aAbs binding from all tested sera (67) of patients with autoimmune thyroid disease (AITD).	Iodine	33-39	thyroglobulin	Homo sapiens	0-13
1954313-8	1991	Excess of iodide (0.2 M KJ) or equimolar concentration of diiodotyrosine protects the Tg molecule from iodine induced inactivation.	Iodides	10-16	thyroglobulin	Homo sapiens	86-88
1954313-8	1991	Excess of iodide (0.2 M KJ) or equimolar concentration of diiodotyrosine protects the Tg molecule from iodine induced inactivation.	Diiodotyrosine	58-72	thyroglobulin	Homo sapiens	86-88
1954313-8	1991	Excess of iodide (0.2 M KJ) or equimolar concentration of diiodotyrosine protects the Tg molecule from iodine induced inactivation.	Iodine	103-109	thyroglobulin	Homo sapiens	86-88
1954313-9	1991	Immunological complexes of Tg with aAbs dissociate at low iodine concentrations.	Iodine	58-64	thyroglobulin	Homo sapiens	27-29
1954313-10	1991	The results suggest that a product of iodine disproportionation reaction induces changes in the Tg molecule and Tg-aAb"s complexes leading to complex dissociation or epitope inactivation.	Iodine	38-44	thyroglobulin	Homo sapiens	96-98
1954313-10	1991	The results suggest that a product of iodine disproportionation reaction induces changes in the Tg molecule and Tg-aAb"s complexes leading to complex dissociation or epitope inactivation.	Iodine	38-44	thyroglobulin	Homo sapiens	112-114
1947763-2	1991	A high serum Tg value during thyroxine suppression therapy is indicative of metastatic disease, but the sensitivity is enhanced by the endogenous TSH response occurring when thyroxine medication is withheld.	Thyroxine	29-38	thyroglobulin	Homo sapiens	13-15
2040337-4	1991	During thyroxine (T4) treatment, the Tg level was undetectable in 98% of patients after total thyroid ablation, in 91% after total thyroidectomy and in 42% after lobectomy only.	Thyroxine	7-16	thyroglobulin	Homo sapiens	37-39
1999676-6	1991	TSH increased the amount of thyroglobulin secreted into the apical medium by five- to sixfold, whereas high basal iodide concentrations (greater than 5 mumol/l) inhibited thyroglobulin secretion by TSH-stimulated cells.	Iodides	114-120	thyroglobulin	Homo sapiens	171-184
1999676-6	1991	TSH increased the amount of thyroglobulin secreted into the apical medium by five- to sixfold, whereas high basal iodide concentrations (greater than 5 mumol/l) inhibited thyroglobulin secretion by TSH-stimulated cells.	Thyrotropin	0-3	thyroglobulin	Homo sapiens	28-41
1999676-12	1991	The maximal incorporation of iodine into thyroglobulin obtained was never higher than 3.5 atoms/mol.	Iodine	29-35	thyroglobulin	Homo sapiens	41-54
2226299-0	1990	Anionic complex-carbohydrate units of human thyroglobulin.	Carbohydrates	16-28	thyroglobulin	Homo sapiens	44-57
18411162-1	1991	In the normal thyroid, but not necessarily in the goitrous gland, the bulk of iodine is bound to thyroglobulin.	Iodine	78-84	thyroglobulin	Homo sapiens	97-110
2075087-1	1990	In the follow-up of thyroid cancer patients we sometimes observed discrepancies between elevated thyroglobulin levels and negative results of posttherapeutic or diagnostic scans 48 h and 72 h after oral application of 131I routinely.	Iodine-131	218-222	thyroglobulin	Homo sapiens	97-110
2226299-1	1990	Human thyroglobulin (hTG) contains sulfate in chondroitin 6-sulfate chains and in complex carbohydrates.	Sulfates	35-42	thyroglobulin	Homo sapiens	6-19
2226299-1	1990	Human thyroglobulin (hTG) contains sulfate in chondroitin 6-sulfate chains and in complex carbohydrates.	Chondroitin Sulfates	46-67	thyroglobulin	Homo sapiens	6-19
2226299-1	1990	Human thyroglobulin (hTG) contains sulfate in chondroitin 6-sulfate chains and in complex carbohydrates.	Carbohydrates	90-103	thyroglobulin	Homo sapiens	6-19
2167682-12	1990	In contrast, CPZ metabolites generated by the MPO system (in the absence of Cl-) induced polymerization of TG, as revealed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE).	Chlorpromazine	13-16	thyroglobulin	Homo sapiens	107-109
2121913-2	1990	Thyroglobulin levels were measured in 61 patients receiving L-thyroxine therapy after thyroidectomy, and again after suspension of therapy, before performing a whole-body scan with iodine-131.	Thyroxine	60-71	thyroglobulin	Homo sapiens	0-13
2121913-3	1990	The sensitivity, specificity, and accuracy of thyroglobulin levels, measured during L-thyroxine therapy, for diagnosis of tumor residue or metastases were then calculated and compared with results obtained by diagnostic whole-body scanning.	Thyroxine	84-95	thyroglobulin	Homo sapiens	46-59
2167217-0	1990	Interleukin-1 beta modulates thyrotropin-induced thyroglobulin mRNA transcription through 3",5"-cyclic adenosine monophosphate.	3",5"-cyclic adenosine monophosphate	90-126	thyroglobulin	Homo sapiens	49-62
2167217-12	1990	We conclude that IL-1 beta possesses hormonal action on TG gene transcription and its effect is mediated via cAMP.	Cyclic AMP	109-113	thyroglobulin	Homo sapiens	56-58
2167682-12	1990	In contrast, CPZ metabolites generated by the MPO system (in the absence of Cl-) induced polymerization of TG, as revealed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE).	Sodium Dodecyl Sulfate	126-149	thyroglobulin	Homo sapiens	107-109
2167682-12	1990	In contrast, CPZ metabolites generated by the MPO system (in the absence of Cl-) induced polymerization of TG, as revealed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE).	polyacrylamide	150-164	thyroglobulin	Homo sapiens	107-109
2167682-12	1990	In contrast, CPZ metabolites generated by the MPO system (in the absence of Cl-) induced polymerization of TG, as revealed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE).	Sodium Dodecyl Sulfate	186-189	thyroglobulin	Homo sapiens	107-109
2245825-0	1990	Occurrence of antithyroxine antibodies in rabbits immunized with iodine-poor human thyroglobulin.	Iodine	65-71	thyroglobulin	Homo sapiens	83-96
18411144-4	1990	Transcription of the thyroglobulin gene is controlled by cAMP through a pathway involving sequence motifs and trans-acting factors that differ from those identified so far in other systems.	Cyclic AMP	57-61	thyroglobulin	Homo sapiens	21-34
2129364-2	1990	The aim of this study was to examine the correlation between the increased TSH levels and Tg, and thyroid hormones in the serum in dependence of pathomorphological thyroid status and the patients" ages.	Thyrotropin	75-78	thyroglobulin	Homo sapiens	90-92
2354167-0	1990	Distribution of Gal alpha 1----3Gal beta 1----4GlcNAc residues on secreted mammalian glycoproteins (thyroglobulin, fibrinogen, and immunoglobulin G) as measured by a sensitive solid-phase radioimmunoassay.	1----3gal beta 1----4glcnac	26-53	thyroglobulin	Homo sapiens	100-113
2377490-0	1990	The poly (purine) poly (pyrimidine) sequence in the 5" end of the thyroglobulin gene used as a probe, identifies a DNA fingerprint in man.	poly (purine) poly (pyrimidine)	4-35	thyroglobulin	Homo sapiens	66-79
2345166-1	1990	Identification of "donor" tyrosine sites for hormonogenesis in thyroglobulin.	Tyrosine	26-34	thyroglobulin	Homo sapiens	63-76
2345166-2	1990	Thyroid hormonogenesis in thyroglobulin results in the conversion of an "acceptor" iodotyrosine to a hormone residue and a "donor" iodotyrosine to a dehydroalanine residue.	Monoiodotyrosine	83-95	thyroglobulin	Homo sapiens	26-39
2345166-2	1990	Thyroid hormonogenesis in thyroglobulin results in the conversion of an "acceptor" iodotyrosine to a hormone residue and a "donor" iodotyrosine to a dehydroalanine residue.	Monoiodotyrosine	131-143	thyroglobulin	Homo sapiens	26-39
2345166-2	1990	Thyroid hormonogenesis in thyroglobulin results in the conversion of an "acceptor" iodotyrosine to a hormone residue and a "donor" iodotyrosine to a dehydroalanine residue.	dehydroalanine	149-163	thyroglobulin	Homo sapiens	26-39
2312106-17	1990	Immunoreactivity for thyroglobulin in metastatic tumors was correlated with the 131I absorption.	Iodine-131	80-84	thyroglobulin	Homo sapiens	21-34
2360457-4	1990	Addition of TSH (10 mU/ml/day) to the culture medium increased the synthesis and release of TG.	Thyrotropin	12-15	thyroglobulin	Homo sapiens	92-94
2312106-18	1990	This finding indicated that immunostaining of thyroglobulin in metastatic tumors might be useful in the prediction of the effectiveness of 131I therapy.	Iodine-131	139-143	thyroglobulin	Homo sapiens	46-59
1969742-4	1990	Tgb RNA has been quantified with cytoplasmic dot blot hybridization and cAMP level with RIA method.	Cyclic AMP	72-76	thyroglobulin	Homo sapiens	0-3
2105202-0	1990	Inhibition of chondroitin sulfate incorporation into human thyroglobulin by p-nitrophenyl-beta-D-xylopyranoside.	Chondroitin Sulfates	14-33	thyroglobulin	Homo sapiens	59-72
2105202-0	1990	Inhibition of chondroitin sulfate incorporation into human thyroglobulin by p-nitrophenyl-beta-D-xylopyranoside.	4-nitrophenyl beta-D-xyloside	76-111	thyroglobulin	Homo sapiens	59-72
2105202-1	1990	Human thyroglobulin (TG) is unique among glycoproteins and TGs of other species in having a chondroitin sulfate chain.	Chondroitin Sulfates	92-111	thyroglobulin	Homo sapiens	6-19
2302248-0	1990	Characterization of the two oligosaccharides present in the preferential hormonogenic domain of human thyroglobulin.	Oligosaccharides	28-44	thyroglobulin	Homo sapiens	102-115
2137773-0	1990	Effects of deoxymannojirimycin and castanospermine on the polarized secretion of thyroglobulin.	1-Deoxynojirimycin	11-30	thyroglobulin	Homo sapiens	81-94
2137773-0	1990	Effects of deoxymannojirimycin and castanospermine on the polarized secretion of thyroglobulin.	castanospermine	35-50	thyroglobulin	Homo sapiens	81-94
2137773-6	1990	The structures of N-glycans borne by Tg, with and without drugs, were checked.	n-glycans	18-27	thyroglobulin	Homo sapiens	37-39
2137773-9	1990	With dMM, complex-type glycans of Tg were totally replaced by high mannose-type glycans, Man8-9GlcNAc; Cs induced the accumulation of glucosylated high mannose-type structures, Glc3Man7-9GlcNAc and Glc2Man8-9GlcNAc, but the action of this inhibitor was not total.	dimethylmyleran	5-8	thyroglobulin	Homo sapiens	34-36
2137773-9	1990	With dMM, complex-type glycans of Tg were totally replaced by high mannose-type glycans, Man8-9GlcNAc; Cs induced the accumulation of glucosylated high mannose-type structures, Glc3Man7-9GlcNAc and Glc2Man8-9GlcNAc, but the action of this inhibitor was not total.	Polysaccharides	23-30	thyroglobulin	Homo sapiens	34-36
2137773-9	1990	With dMM, complex-type glycans of Tg were totally replaced by high mannose-type glycans, Man8-9GlcNAc; Cs induced the accumulation of glucosylated high mannose-type structures, Glc3Man7-9GlcNAc and Glc2Man8-9GlcNAc, but the action of this inhibitor was not total.	castanospermine	103-105	thyroglobulin	Homo sapiens	34-36
1688407-6	1990	The binding of 5 mAbs to native human Tg was inhibited by thyroxine.	Thyroxine	58-67	thyroglobulin	Homo sapiens	38-40
1688408-10	1990	Naturally occurring Tg autoantibodies from healthy subjects recognized mainly thyroxine-containing cross-reactive determinants.	Thyroxine	78-87	thyroglobulin	Homo sapiens	20-22
34599677-10	2022	There was a negative association of iodine intake with Tg values among the study population.	Iodine	36-42	thyroglobulin	Homo sapiens	55-57
33768075-5	2021	After 6 cycles of erlotinib, thoracic CT showed a decrease in the dimensions of the primary pulmonary tumour, but an increase in the size and number of pulmonary metastases while blood tests showed elevated thyroglobulin.	Erlotinib Hydrochloride	18-27	thyroglobulin	Homo sapiens	207-220
34941104-10	2021	OUTCOMES: After complete treatment with surgery and radioiodine therapy, the serum thyroglobulin level was 10 ng/ml.	Iodine-131	52-63	thyroglobulin	Homo sapiens	83-96
34325091-0	2021	Highly sensitive electrochemical immunosensor using a protein-polyvinylidene fluoride nanocomposite for human thyroglobulin.	polyvinylidene fluoride	62-85	thyroglobulin	Homo sapiens	110-123
34325091-1	2021	The highly sensitive detection of serum thyroglobulin (Tg) is essential in the post-treatment follow-up of patients with differentiated thyroid cancer undergoing total or partial thyroidectomy and radioactive iodine ablation and requires sensitive, accurate and stable methods.	radioactive iodine	197-215	thyroglobulin	Homo sapiens	40-53
34325091-1	2021	The highly sensitive detection of serum thyroglobulin (Tg) is essential in the post-treatment follow-up of patients with differentiated thyroid cancer undergoing total or partial thyroidectomy and radioactive iodine ablation and requires sensitive, accurate and stable methods.	radioactive iodine	197-215	thyroglobulin	Homo sapiens	55-57
34325091-2	2021	This work proposes an electrochemical immunosensor for the detection of serum Tg antigen, making use of innovative nanocomposites including polyvinylidene fluoride (PVDF) microparticles coated with streptavidin (MP) and gold nanoparticles (AuNPs).	polyvinylidene fluoride	140-163	thyroglobulin	Homo sapiens	78-80
34325091-2	2021	This work proposes an electrochemical immunosensor for the detection of serum Tg antigen, making use of innovative nanocomposites including polyvinylidene fluoride (PVDF) microparticles coated with streptavidin (MP) and gold nanoparticles (AuNPs).	polyvinylidene fluoride	165-169	thyroglobulin	Homo sapiens	78-80
34325091-4	2021	Immobilization of biotin-labeled anti-thyroglobulin monoclonal antibodies was achieved by binding these to the polymer nanocomposite via streptavidin proteins.	Biotin	18-24	thyroglobulin	Homo sapiens	38-51
34325091-4	2021	Immobilization of biotin-labeled anti-thyroglobulin monoclonal antibodies was achieved by binding these to the polymer nanocomposite via streptavidin proteins.	Polymers	111-118	thyroglobulin	Homo sapiens	38-51
34787181-8	2021	Thyroglobulin was determined in 20% of the studies and reflected the pre-existing state of iodine.	Iodine	91-97	thyroglobulin	Homo sapiens	0-13
2151126-13	1990	These two proteins are highly immunogenic: the thyroglobulin due to its increased iodine content and the thyroid peroxidase because it is a membrane-bound antigen sequestered in thyroid follicles.	Iodine	82-88	thyroglobulin	Homo sapiens	47-60
33824601-0	2021	Value of 18F-FDG Hybrid PET/MR in Differentiated Thyroid Cancer Patients with Negative 131I Whole-Body Scan and Elevated Thyroglobulin Levels.	Fluorodeoxyglucose F18	9-16	thyroglobulin	Homo sapiens	121-134
33824601-2	2021	The relationship between 18F-FDG PET/MR and serum Tg levels was explored.	Fluorodeoxyglucose F18	25-32	thyroglobulin	Homo sapiens	50-52
34896620-0	2022	TSH stimulation of human thyroglobulin and thyroid peroxidase gene transcription is partially dependent on internalization.	Thyrotropin	0-3	thyroglobulin	Homo sapiens	25-38
34658559-1	2021	Thyroglobulin-elevated negative iodine scan (TENIS) syndrome represents a significant diagnostic and therapeutic challenge.	Iodine	32-38	thyroglobulin	Homo sapiens	0-13
34595070-8	2021	Unfortunately, her thyroglobulin continued to increase post-radioactive iodine (RAI) treatment, indicating persistent and/or recurrent thyroid cancer.	radioactive iodine	60-78	thyroglobulin	Homo sapiens	19-32
34441364-14	2021	A significant association was found between therapeutic approach, metabolic response, and final disease response evaluation, as well as a linear correlation between MTV and TLG with thyroglobulin level.	mtv	165-168	thyroglobulin	Homo sapiens	182-195
34441364-14	2021	A significant association was found between therapeutic approach, metabolic response, and final disease response evaluation, as well as a linear correlation between MTV and TLG with thyroglobulin level.	(5r)-3-Acetyl-4-Hydroxy-5-Methyl-5-[(1z)-2-Methylbuta-1,3-Dien-1-Yl]thiophen-2(5h)-One	173-176	thyroglobulin	Homo sapiens	182-195
34444680-0	2021	Reflection of Dietary Iodine in the 24 h Urinary Iodine Concentration, Serum Iodine and Thyroglobulin as Biomarkers of Iodine Status: A Pilot Study.	dietary iodine	14-28	thyroglobulin	Homo sapiens	88-101
34298840-0	2021	Pre-Therapeutic Measurements of Iodine Avidity in Papillary and Poorly Differentiated Thyroid Cancer Reveal Associations with Thyroglobulin Expression, Histological Variants and Ki-67 Index.	Iodine	32-38	thyroglobulin	Homo sapiens	126-139
34484748-0	2021	Intra-amniotic levothyroxine infusions in a case of fetal goiter due to novel Thyroglobulin gene variants.	Thyroxine	15-28	thyroglobulin	Homo sapiens	78-91
34262343-0	2021	Preablative Stimulated Thyroglobulin and Thyroglobulin Reduction Index as Decision-Making Markers for Second Radioactive Iodine Therapy in Patients with Structural Incomplete Response.	radioactive iodine	109-127	thyroglobulin	Homo sapiens	41-54
34262343-1	2021	Purpose: The aim of this study was to evaluate the value of preablative stimulated thyroglobulin (presTg) and thyroglobulin reduction index (TRI) to predict the different responses to second radioactive iodine (RAI) therapy in differentiated thyroid cancer (DTC) patients with structural incomplete response (SIR).	radioactive iodine	191-209	thyroglobulin	Homo sapiens	83-96
34262343-1	2021	Purpose: The aim of this study was to evaluate the value of preablative stimulated thyroglobulin (presTg) and thyroglobulin reduction index (TRI) to predict the different responses to second radioactive iodine (RAI) therapy in differentiated thyroid cancer (DTC) patients with structural incomplete response (SIR).	radioactive iodine	191-209	thyroglobulin	Homo sapiens	110-123
34262343-1	2021	Purpose: The aim of this study was to evaluate the value of preablative stimulated thyroglobulin (presTg) and thyroglobulin reduction index (TRI) to predict the different responses to second radioactive iodine (RAI) therapy in differentiated thyroid cancer (DTC) patients with structural incomplete response (SIR).	Insulin, Short-Acting	211-214	thyroglobulin	Homo sapiens	83-96
34262343-1	2021	Purpose: The aim of this study was to evaluate the value of preablative stimulated thyroglobulin (presTg) and thyroglobulin reduction index (TRI) to predict the different responses to second radioactive iodine (RAI) therapy in differentiated thyroid cancer (DTC) patients with structural incomplete response (SIR).	Insulin, Short-Acting	211-214	thyroglobulin	Homo sapiens	110-123
34107643-1	2021	BACKGROUND: To evaluate the value of preablative stimulated thyroglobulin (ps-Tg) before the first radioactive ablation iodine (RAI) treatment to predict the postoperative metastasis of DTC.	Iodine	120-126	thyroglobulin	Homo sapiens	60-73
34107643-1	2021	BACKGROUND: To evaluate the value of preablative stimulated thyroglobulin (ps-Tg) before the first radioactive ablation iodine (RAI) treatment to predict the postoperative metastasis of DTC.	Ditiocarb	186-189	thyroglobulin	Homo sapiens	60-73
35237910-0	2022	Value of stimulated pre-ablation thyroglobulin as a prognostic marker in patients with differentiated thyroid carcinoma treated with radioiodine.	Iodine-131	133-144	thyroglobulin	Homo sapiens	33-46
34066574-1	2021	We investigated whether an indication for (18F)FDG-PET/CT to detect FDG-avid persistent disease (PD) could be identified precisely using the extent of metastatic lymph nodes (MLNs) and serum thyroglobulin (Tg) in papillary thyroid cancer (PTC) patients.	Fluorodeoxyglucose F18	68-71	thyroglobulin	Homo sapiens	191-204
35412871-1	2022	BACKGROUND: The utility of serum thyroglobulin (Tg) measurement following partial thyroidectomy or total/near total thyroidectomy without radioactive iodine (RAI) for differentiated thyroid cancer (DTC) is unclear.	Insulin, Short-Acting	158-161	thyroglobulin	Homo sapiens	33-46
35096430-6	2022	Due to recurrent findings of residual thyroid tissue on whole-body scan imaging, the patient underwent radioactive iodine ablation therapy twice, with poor response to therapy, suggested by persistently elevated thyroglobulin levels.	radioactive iodine	103-121	thyroglobulin	Homo sapiens	212-225
35521710-1	2022	Objective To evaluate usefulness of (18F)fluorodeoxyglucose (FDG) PET/CT in patients with low detectable thyroglobulin levels suspicious for persistent or recurrent differentiated thyroid cancer (DTC).	Fluorodeoxyglucose F18	36-59	thyroglobulin	Homo sapiens	105-118
35571749-11	2022	Of interest, four studies reported that selenium supplementation reduced the incidence of thyroid dysfunction and permanent hypothyroidism during the postpartum period by reducing thyroid peroxidase and thyroglobulin antibody titres.	Selenium	40-48	thyroglobulin	Homo sapiens	203-216
33538049-0	2022	Thyroglobulin determination on silane-antibody functionalized interdigitated dielectrode surface to diagnose thyroid tumor.	dielectrode	77-88	thyroglobulin	Homo sapiens	0-13
35513447-0	2022	Thyroglobulin levels among iodine deficient pregnant women living in Northern Ireland.	Iodine	27-33	thyroglobulin	Homo sapiens	0-13
35513447-2	2022	Thyroglobulin (Tg) is a protein produced uniquely by the thyroid gland which appears to mount a U-shaped response to extremes of iodine status.	Iodine	129-135	thyroglobulin	Homo sapiens	0-13
35464061-1	2022	Background and Purpose: This study aimed to analyze the diagnostic ability of the combination of stimulated thyroglobulin (sTg) and antithyroglobulin antibody (TgAb) in predicting the efficacy and prognosis of radioactive iodine (131I) therapy (RAIT) in patients with differentiated thyroid carcinomas (DTCs) after total thyroidectomy (TT).	radioactive iodine	210-228	thyroglobulin	Homo sapiens	108-121
35256297-3	2022	18F-FDG PET/CT has a proven role in detecting recurrent disease or the metastatic workup of the thyroglobulin elevated negative radioiodine scan (TENIS) scenario.	Fluorodeoxyglucose F18	0-7	thyroglobulin	Homo sapiens	96-109
35083346-0	2022	Impact of 18F-FDG PET/CT on treatment of patients with differentiated thyroid carcinoma, negative 131I whole body scan and elevated serum thyroglobulin.	Fluorodeoxyglucose F18	10-17	thyroglobulin	Homo sapiens	138-151
35013249-1	2022	The thyroglobulin (TG) protein is essential to thyroid hormone synthesis, plays a vital role in the regulation of metabolism, development and growth and serves as intraglandular iodine storage.	Iodine	178-184	thyroglobulin	Homo sapiens	4-17
35083346-2	2022	The aim of this study was to assess the clinical impact of 18F-FDG PET/CT on the management of patients with differentiated thyroid carcinoma who had elevated serum thyroglobulin (Tg) and negative 131I whole body scan (WBS).	Fluorodeoxyglucose F18	59-66	thyroglobulin	Homo sapiens	165-178
35083346-5	2022	The diagnostic accuracy of 18F-FDG PET/CT was evaluated for the entire patient group and for those patients with stimulated serum thyroglobulin levels of less than 5, 5-10, and more than 10 pmol/L as well as for local recurrences and metastases sites.	Fluorodeoxyglucose F18	27-34	thyroglobulin	Homo sapiens	130-143
35083346-10	2022	Positive 18F-FDG PET/CT findings were directly correlated with stimulated serum thyroglobulin levels, 7.1% had Tg between 5-10, and 92.9% had Tg greater than 10 pmol/L.	Fluorodeoxyglucose F18	9-16	thyroglobulin	Homo sapiens	80-93
35083346-12	2022	Conclusion: 18F-FDG PET/CT is able to improve diagnostic accuracy and have management impact in a therapeutically relevant way in patients with differentiated thyroid carcinoma who present with rising thyroglobulin level, negative 131I WBS, and clinical suspicion of recurrent disease.	Fluorodeoxyglucose F18	12-19	thyroglobulin	Homo sapiens	201-214
2745934-6	1989	If a coupling defect was the cause of the disorder, iodotyrosines would have to cycle between the thyroid cell and thyroglobulin in the follicular lumen undergoing deiodination, and reorganification continually.	Monoiodotyrosine	52-65	thyroglobulin	Homo sapiens	115-128
2584351-15	1989	However, small amounts of functionally active Tg could be synthesized, iodinated, and immediately hydrolized, yielding mostly T3, owing to the intense tissue stimulation by TSH.	Thyrotropin	173-176	thyroglobulin	Homo sapiens	46-48
2760035-1	1989	Thyroglobulin from a human goiter, containing four atoms of iodine/molecule (660,000 daltons), was iodinated with Na 125I and KI in vitro to achieve a net addition of either 2 or 7.8 atoms of iodine/molecule.	Iodine	60-66	thyroglobulin	Homo sapiens	0-13
2760035-1	1989	Thyroglobulin from a human goiter, containing four atoms of iodine/molecule (660,000 daltons), was iodinated with Na 125I and KI in vitro to achieve a net addition of either 2 or 7.8 atoms of iodine/molecule.	Iodine	192-198	thyroglobulin	Homo sapiens	0-13
2760035-2	1989	After fractionation by high performance liquid chromatography, iodinated tryptic peptides from S-cyanoethylated 125I-thyroglobulin were purified, sequenced, characterized by [125I]iodoamino acid distribution, and localized within thyroglobulins primary structure based upon the published cDNA sequence, (Malthiery, Y., and Lissitsky, S. (1987) Eur.	Peptides	81-89	thyroglobulin	Homo sapiens	117-130
2760035-5	1989	The addition of 2 atoms of iodine/molecule of thyroglobulin produced iodotyrosyls at five principal sites, with no 125I-hormone formation.	Iodine	27-33	thyroglobulin	Homo sapiens	46-59
2760035-5	1989	The addition of 2 atoms of iodine/molecule of thyroglobulin produced iodotyrosyls at five principal sites, with no 125I-hormone formation.	iodotyrosyls	69-81	thyroglobulin	Homo sapiens	46-59
2753971-0	1989	Changes in serum thyroid hormone, thyrotropin and thyroglobulin concentrations during thyroxine therapy in patients with solitary thyroid nodules.	Thyroxine	86-95	thyroglobulin	Homo sapiens	50-63
2788696-5	1989	Both IL-1 alpha and beta inhibited TSH-induced Tg release at concentrations ranging from 0.01 to 10 U/ml.	Thyrotropin	35-38	thyroglobulin	Homo sapiens	47-49
2788696-9	1989	Both IL-1 alpha and beta inhibited TSH-induced Tg mRNA in a dose-responsive manner.	Thyrotropin	35-38	thyroglobulin	Homo sapiens	47-49
2788696-13	1989	These results demonstrate that IL-1 directly inhibits TSH-induced Tg gene expression and provide further support for a functional role of IL-1 as a local modulator of thyroid hormone synthesis.	Thyrotropin	54-57	thyroglobulin	Homo sapiens	66-68
2723027-8	1989	These results suggest that human thyroid cells contain four distinct TPO mRNAs and a single species of Tg mRNA, and the levels of all mRNAs are increased by TSH/cAMP stimulation.	Thyrotropin	157-160	thyroglobulin	Homo sapiens	103-105
2723027-8	1989	These results suggest that human thyroid cells contain four distinct TPO mRNAs and a single species of Tg mRNA, and the levels of all mRNAs are increased by TSH/cAMP stimulation.	Cyclic AMP	161-165	thyroglobulin	Homo sapiens	103-105
2541706-0	1989	cAMP-dependent binding of a trans-acting factor to the thyroglobulin promoter.	Cyclic AMP	0-4	thyroglobulin	Homo sapiens	55-68
2541706-1	1989	We have investigated the interaction of a nuclear factor(s) with the promoter region of the thyroglobulin (Tg) gene, which is only expressed in differentiated thyroid cells under the positive control of the pituitary hormone thyrotropin (TSH) via a cAMP-dependent pathway.	Cyclic AMP	249-253	thyroglobulin	Homo sapiens	92-105
2541706-1	1989	We have investigated the interaction of a nuclear factor(s) with the promoter region of the thyroglobulin (Tg) gene, which is only expressed in differentiated thyroid cells under the positive control of the pituitary hormone thyrotropin (TSH) via a cAMP-dependent pathway.	Cyclic AMP	249-253	thyroglobulin	Homo sapiens	107-109
2624667-2	1989	False positives in the ELISA for the detection of TMA due to interference by thyroglobulin antibodies (TGA) present in some test sera reacting with thyroglobulin (Tg) present as a contaminant in the thyroid microsomal preparation (TMP) appears to be common.	tmp	231-234	thyroglobulin	Homo sapiens	77-90
2624667-2	1989	False positives in the ELISA for the detection of TMA due to interference by thyroglobulin antibodies (TGA) present in some test sera reacting with thyroglobulin (Tg) present as a contaminant in the thyroid microsomal preparation (TMP) appears to be common.	tmp	231-234	thyroglobulin	Homo sapiens	148-161
2805343-1	1989	The value of serum thyroglobulin assay employing a kit manufactured by Diagnostic Products Corporation in the detection of recurrence of thyroid carcinoma in patients treated by thyroidectomy and ablative therapy was assessed by clinical follow-up and radioiodine scanning of 122 patients over a 2-year period.	Iodine-131	252-263	thyroglobulin	Homo sapiens	19-32
2546939-0	1989	Thyroglobulin-mediated one- and two-electron oxidations of glutathione and ascorbate in thyroid peroxidase systems.	Glutathione	59-70	thyroglobulin	Homo sapiens	0-13
2546939-0	1989	Thyroglobulin-mediated one- and two-electron oxidations of glutathione and ascorbate in thyroid peroxidase systems.	Ascorbic Acid	75-84	thyroglobulin	Homo sapiens	0-13
2546939-1	1989	The one- or two-electron oxidation of thyroglobulin by the thyroid peroxidase system was found to be regulated by the iodine content of thyroglobulin.	Iodine	118-124	thyroglobulin	Homo sapiens	38-51
2546939-1	1989	The one- or two-electron oxidation of thyroglobulin by the thyroid peroxidase system was found to be regulated by the iodine content of thyroglobulin.	Iodine	118-124	thyroglobulin	Homo sapiens	136-149
2546939-2	1989	The catalytic intermediate of thyroid peroxidase observed at steady state of the reaction was Compound I and II when the iodine content in thyroglobulin was 0.2 and 0.7%, respectively, apparent rate constants for the rate-limiting steps being estimated at 4.7 x 10(7) and 4.8 x 10(4) M-1 S-1.	Iodine	121-127	thyroglobulin	Homo sapiens	139-152
2546939-3	1989	The thyroglobulin-mediated oxidation of GSH occurred by way of two-electron transfer at 0.2% iodine content and by way of one-electron transfer at 0.7% iodine content.	Glutathione	40-43	thyroglobulin	Homo sapiens	4-17
2546939-3	1989	The thyroglobulin-mediated oxidation of GSH occurred by way of two-electron transfer at 0.2% iodine content and by way of one-electron transfer at 0.7% iodine content.	Iodine	93-99	thyroglobulin	Homo sapiens	4-17
2546939-3	1989	The thyroglobulin-mediated oxidation of GSH occurred by way of two-electron transfer at 0.2% iodine content and by way of one-electron transfer at 0.7% iodine content.	Iodine	152-158	thyroglobulin	Homo sapiens	4-17
2547614-2	1989	Thyroglobulin has been shown to be phosphorylated and to carry the mannose 6-phosphate (M6P) signal in terminal position.	mannose-6-phosphate	67-86	thyroglobulin	Homo sapiens	0-13
2547614-2	1989	Thyroglobulin has been shown to be phosphorylated and to carry the mannose 6-phosphate (M6P) signal in terminal position.	mannose-6-phosphate	88-91	thyroglobulin	Homo sapiens	0-13
2765955-1	1989	The following methods have been introduced at our institute: labeling of human thyroglobulin (H-Tg) with the radioiodine 125I by the lactoperoxidase method, radioimmunologic method for serum H-Tg determination by means of rabbit antiserum to H-Tg prepared at our institute, and radioimmunologic method for the determination of antibodies to thyroglobulin.	Iodine-131	109-120	thyroglobulin	Homo sapiens	79-92
2765955-1	1989	The following methods have been introduced at our institute: labeling of human thyroglobulin (H-Tg) with the radioiodine 125I by the lactoperoxidase method, radioimmunologic method for serum H-Tg determination by means of rabbit antiserum to H-Tg prepared at our institute, and radioimmunologic method for the determination of antibodies to thyroglobulin.	h-tg	94-98	thyroglobulin	Homo sapiens	79-92
3190232-1	1988	A series of low iodine human thyroglobulin samples derived from colloid-rich goiter tissue was examined by HPLC mapping of tryptic digests and compared to normal human thyroglobulin.	Iodine	16-22	thyroglobulin	Homo sapiens	29-42
2744218-5	1989	The inhibiting effect of amiodarone and propranolol on follicular production of cAMP, Tg and FT3 appears to result from several factors: (1) inhibition of thyroid 5"-deiodinase; (2) amiodarone high iodine content; (3) a quinidine-like effect of propranolol involving a membrane-stabilizing mechanism.	Amiodarone	25-35	thyroglobulin	Homo sapiens	86-88
2744218-5	1989	The inhibiting effect of amiodarone and propranolol on follicular production of cAMP, Tg and FT3 appears to result from several factors: (1) inhibition of thyroid 5"-deiodinase; (2) amiodarone high iodine content; (3) a quinidine-like effect of propranolol involving a membrane-stabilizing mechanism.	Propranolol	40-51	thyroglobulin	Homo sapiens	86-88
2541597-0	1989	Induction of peroxidase and thyroglobulin by TSH in cultured thyroid cells from patients with Basedow"s disease and its inhibition by actinomycin D.	Thyrotropin	45-48	thyroglobulin	Homo sapiens	28-41
2541597-0	1989	Induction of peroxidase and thyroglobulin by TSH in cultured thyroid cells from patients with Basedow"s disease and its inhibition by actinomycin D.	Dactinomycin	134-147	thyroglobulin	Homo sapiens	28-41
2495820-1	1989	Thyroglobulin is a large-size iodoglycoprotein specific to thyroid tissue and is the substrate for the synthesis of thyroid hormones, thyroxine and 3,5,3"-triiodothyronine.	Thyroxine	134-143	thyroglobulin	Homo sapiens	0-13
2495820-1	1989	Thyroglobulin is a large-size iodoglycoprotein specific to thyroid tissue and is the substrate for the synthesis of thyroid hormones, thyroxine and 3,5,3"-triiodothyronine.	3,5,3"-triiodothyronine	148-171	thyroglobulin	Homo sapiens	0-13
2531019-3	1989	This rapidly excreted fraction exhibits a low density on rubidium chloride gradients characteristic of poorly sialylated and poorly iodinated thyroglobulin, comigrating on rubidium chloride gradients with thyroglobulin isolated from tunicamycin treated glands.	Tunicamycin	233-244	thyroglobulin	Homo sapiens	142-155
2531019-3	1989	This rapidly excreted fraction exhibits a low density on rubidium chloride gradients characteristic of poorly sialylated and poorly iodinated thyroglobulin, comigrating on rubidium chloride gradients with thyroglobulin isolated from tunicamycin treated glands.	Tunicamycin	233-244	thyroglobulin	Homo sapiens	205-218
2491808-0	1989	Differential incorporation of sulfate into the chondroitin chain and complex carbohydrate chains of human thyroglobulin: studies in normal and neoplastic thyroid tissue.	Carbohydrates	77-89	thyroglobulin	Homo sapiens	106-119
2491808-1	1989	Human thyroglobulin (TG) is one of a growing number of glycoproteins that are known to contain sulfate.	Sulfates	95-102	thyroglobulin	Homo sapiens	6-19
2570483-10	1989	The basal release of immunodetectable Tg, as measured in a perifusion system, increased in response to thyroid stimulating hormone (TSH) (P less than 0.025) or TSH combined with theophylline (P less than 0.001).	Thyrotropin	103-130	thyroglobulin	Homo sapiens	38-40
2570483-10	1989	The basal release of immunodetectable Tg, as measured in a perifusion system, increased in response to thyroid stimulating hormone (TSH) (P less than 0.025) or TSH combined with theophylline (P less than 0.001).	Thyrotropin	132-135	thyroglobulin	Homo sapiens	38-40
2570483-10	1989	The basal release of immunodetectable Tg, as measured in a perifusion system, increased in response to thyroid stimulating hormone (TSH) (P less than 0.025) or TSH combined with theophylline (P less than 0.001).	Thyrotropin	160-163	thyroglobulin	Homo sapiens	38-40
2570483-10	1989	The basal release of immunodetectable Tg, as measured in a perifusion system, increased in response to thyroid stimulating hormone (TSH) (P less than 0.025) or TSH combined with theophylline (P less than 0.001).	Theophylline	178-190	thyroglobulin	Homo sapiens	38-40
2744218-3	1989	Amiodarone and propranolol induced a dose-dependent reduction or blocking of the follicular production of cyclic AMP (cAMP), thyroglobulin (Tg) and free triiodothyronine (FT3) under 200 microU/ml medium.	Amiodarone	0-10	thyroglobulin	Homo sapiens	125-138
2744218-3	1989	Amiodarone and propranolol induced a dose-dependent reduction or blocking of the follicular production of cyclic AMP (cAMP), thyroglobulin (Tg) and free triiodothyronine (FT3) under 200 microU/ml medium.	Amiodarone	0-10	thyroglobulin	Homo sapiens	140-142
2744218-3	1989	Amiodarone and propranolol induced a dose-dependent reduction or blocking of the follicular production of cyclic AMP (cAMP), thyroglobulin (Tg) and free triiodothyronine (FT3) under 200 microU/ml medium.	Propranolol	15-26	thyroglobulin	Homo sapiens	125-138
2744218-3	1989	Amiodarone and propranolol induced a dose-dependent reduction or blocking of the follicular production of cyclic AMP (cAMP), thyroglobulin (Tg) and free triiodothyronine (FT3) under 200 microU/ml medium.	Propranolol	15-26	thyroglobulin	Homo sapiens	140-142
2745931-8	1989	The rapid effect of prednisone suggests an impairement of proteolysis of thyroglobulin possibly due to a lysosomal action.	Prednisone	20-30	thyroglobulin	Homo sapiens	73-86
3179315-1	1988	The interaction between the carbohydrate and the amino acid residues in human thyroglobulin has been studied.	Carbohydrates	28-40	thyroglobulin	Homo sapiens	78-91
3179315-2	1988	Previous reports showed that the removal of the two terminal carbohydrates of the complex chains leads to an increase in thyroglobulin binding to thyroid membranes.	Carbohydrates	61-74	thyroglobulin	Homo sapiens	121-134
3179315-3	1988	In our study, after enzymatic release with glycosidases of the sugar moieties from thyroglobulin, a time-dependent decrease in tryptophan fluorescence has been observed.	Sugars	63-68	thyroglobulin	Homo sapiens	83-96
3179315-3	1988	In our study, after enzymatic release with glycosidases of the sugar moieties from thyroglobulin, a time-dependent decrease in tryptophan fluorescence has been observed.	Tryptophan	127-137	thyroglobulin	Homo sapiens	83-96
3190232-12	1988	These data confirm that the human thyroglobulin molecule is capable of forming at least limited amounts of thyroid hormone at iodine levels as low as 4 g.a.	Iodine	126-132	thyroglobulin	Homo sapiens	34-47
3221044-0	1988	Serum thyroglobulin concentration may be a clue to the mechanism of amiodarone-induced thyrotoxicosis.	Amiodarone	68-78	thyroglobulin	Homo sapiens	6-19
2464449-4	1988	Furthermore, using human thyroglobulin manifesting different levels of iodination, it was possible to show that sera with recognition pattern 1 recognized the iodination site of thyroglobulin and that this was inhibitable by thyroxine.	Thyroxine	225-234	thyroglobulin	Homo sapiens	25-38
2464449-4	1988	Furthermore, using human thyroglobulin manifesting different levels of iodination, it was possible to show that sera with recognition pattern 1 recognized the iodination site of thyroglobulin and that this was inhibitable by thyroxine.	Thyroxine	225-234	thyroglobulin	Homo sapiens	178-191
3251664-0	1988	TSH dependent elevation of serum thyroglobulin in reversible primary hypothyroidism.	Thyrotropin	0-3	thyroglobulin	Homo sapiens	33-46
3416427-0	1988	Nonisotopic "sandwich" immunoassay of thyroglobulin in serum by the biotin-streptavidin technique: evaluation and comparison with an immunoradiometric assay.	Biotin	68-74	thyroglobulin	Homo sapiens	38-51
3416427-1	1988	In this sequential assay, the thyroglobulin in serum binds to polystyrene beads coated with two mouse monoclonal antibodies.	Polystyrenes	62-73	thyroglobulin	Homo sapiens	30-43
3414314-2	1988	In the case of such a correlation serum thyroglobulin could be used to predict which goitres respond to thyroxine therapy and which require surgery.	Thyroxine	104-113	thyroglobulin	Homo sapiens	40-53
3251664-3	1988	In all of these 12 patients, thyroid function recovered spontaneously with only iodide restriction and the serum Tg levels declined concomitantly with the decrease in serum TSH concentrations, events suggesting the TSH dependency of this Tg elevation.	Thyrotropin	173-176	thyroglobulin	Homo sapiens	238-240
3251664-3	1988	In all of these 12 patients, thyroid function recovered spontaneously with only iodide restriction and the serum Tg levels declined concomitantly with the decrease in serum TSH concentrations, events suggesting the TSH dependency of this Tg elevation.	Thyrotropin	215-218	thyroglobulin	Homo sapiens	113-115
3251664-3	1988	In all of these 12 patients, thyroid function recovered spontaneously with only iodide restriction and the serum Tg levels declined concomitantly with the decrease in serum TSH concentrations, events suggesting the TSH dependency of this Tg elevation.	Thyrotropin	215-218	thyroglobulin	Homo sapiens	238-240
3221173-0	1988	Development of immunoradiometric assays for human thyroglobulin using monoclonal antibodies and the biotin/avidin system.	Biotin	100-106	thyroglobulin	Homo sapiens	50-63
3409477-0	1988	Monoiodotyrosine formation during thyroglobulin processing in Golgi vesicles.	Monoiodotyrosine	0-16	thyroglobulin	Homo sapiens	34-47
3409477-5	1988	It is concluded that in vitro, iodination can begin before exocytosis, in the smooth-surfaced vesicles derived from the golgi apparatus, as soon as N-acetylglucosamine is incorporated onto the pre-thyroglobulin molecule.	Acetylglucosamine	148-167	thyroglobulin	Homo sapiens	197-210
3378632-0	1988	Improvement in HPLC fractionation of thyroxine-containing thyroglobulin tryptic peptides by prior Accell ion-exchange column chromatography.	Thyroxine	37-46	thyroglobulin	Homo sapiens	58-71
3131116-0	1988	Metabolic labeling of human thyroglobulin with [35S]sulfate: incorporation into chondroitin 6-sulfate and endoglycosidase-F-susceptible carbohydrate units.	Sulfur-35	48-51	thyroglobulin	Homo sapiens	28-41
3131116-0	1988	Metabolic labeling of human thyroglobulin with [35S]sulfate: incorporation into chondroitin 6-sulfate and endoglycosidase-F-susceptible carbohydrate units.	Sulfates	52-59	thyroglobulin	Homo sapiens	28-41
3131116-0	1988	Metabolic labeling of human thyroglobulin with [35S]sulfate: incorporation into chondroitin 6-sulfate and endoglycosidase-F-susceptible carbohydrate units.	Chondroitin Sulfates	80-101	thyroglobulin	Homo sapiens	28-41
3131116-0	1988	Metabolic labeling of human thyroglobulin with [35S]sulfate: incorporation into chondroitin 6-sulfate and endoglycosidase-F-susceptible carbohydrate units.	Carbohydrates	136-148	thyroglobulin	Homo sapiens	28-41
3131116-2	1988	Labeled thyroglobulin was purified by ammonium sulfate precipitation, gel exclusion chromatography, and equilibrium density gradient centrifugation, the last of these specifically to remove proteoglycans.	Ammonium Sulfate	38-54	thyroglobulin	Homo sapiens	8-21
3131116-3	1988	[35S]Sulfate was found in thyroglobulin with low density, indicating that sulfate was incorporated into newly synthesized molecules before their iodination.	Sulfur-35	1-4	thyroglobulin	Homo sapiens	26-39
3131116-3	1988	[35S]Sulfate was found in thyroglobulin with low density, indicating that sulfate was incorporated into newly synthesized molecules before their iodination.	Sulfates	5-12	thyroglobulin	Homo sapiens	26-39
3131116-3	1988	[35S]Sulfate was found in thyroglobulin with low density, indicating that sulfate was incorporated into newly synthesized molecules before their iodination.	Sulfates	74-81	thyroglobulin	Homo sapiens	26-39
3131116-8	1988	Thus, human thyroglobulin contains sulfate in at least three types of carbohydrate units, 1) chondroitin 6-sulfate units, 2) complex units with no affinity for Concanavalin-A (tri- or tetraantennary forms), and 3) complex units with weak affinity for Concanavalin-A (biantennary forms).	Sulfates	35-42	thyroglobulin	Homo sapiens	12-25
3131116-8	1988	Thus, human thyroglobulin contains sulfate in at least three types of carbohydrate units, 1) chondroitin 6-sulfate units, 2) complex units with no affinity for Concanavalin-A (tri- or tetraantennary forms), and 3) complex units with weak affinity for Concanavalin-A (biantennary forms).	Carbohydrates	70-82	thyroglobulin	Homo sapiens	12-25
3131116-8	1988	Thus, human thyroglobulin contains sulfate in at least three types of carbohydrate units, 1) chondroitin 6-sulfate units, 2) complex units with no affinity for Concanavalin-A (tri- or tetraantennary forms), and 3) complex units with weak affinity for Concanavalin-A (biantennary forms).	Chondroitin Sulfates	93-114	thyroglobulin	Homo sapiens	12-25
3402664-1	1988	Hog thyroglobulin was treated with the monoclonal anti-thyroglobulin antibody, 16.3.2, which recognizes the thyroxine residues of thyroglobulin.	Thyroxine	108-117	thyroglobulin	Homo sapiens	4-17
3402664-1	1988	Hog thyroglobulin was treated with the monoclonal anti-thyroglobulin antibody, 16.3.2, which recognizes the thyroxine residues of thyroglobulin.	Thyroxine	108-117	thyroglobulin	Homo sapiens	55-68
3402664-1	1988	Hog thyroglobulin was treated with the monoclonal anti-thyroglobulin antibody, 16.3.2, which recognizes the thyroxine residues of thyroglobulin.	Thyroxine	108-117	thyroglobulin	Homo sapiens	55-68
3402664-2	1988	Size-exclusion high-performance liquid chromatography of the immune complexes indicated that there were 3.5 immunoreactable thyroxine residues/mol of 19 S thyroglobulin.	Thyroxine	124-133	thyroglobulin	Homo sapiens	155-168
3402664-6	1988	Based on the morphology of the immune complexes, we conclude that thyroxine residues are formed preferentially on the molecular surface and localized near both ends of the elongated molecule of 19 S thyroglobulin and possibly at one side of the middle of the molecule.	Thyroxine	66-75	thyroglobulin	Homo sapiens	199-212
3168324-1	1988	In vitro anti-thyroglobulin antibody (TgAb) production by unstimulated, thyroglobulin (Tg)-stimulated and pokeweed mitogen (PWM)-stimulated peripheral blood lymphocytes (PBL) from 44 patients with Hashimoto"s thyroiditis and 10 normal individuals was investigated using a biotin-avidin enzyme-linked immunosorbent assay.	Biotin	272-278	thyroglobulin	Homo sapiens	14-27
3378632-0	1988	Improvement in HPLC fractionation of thyroxine-containing thyroglobulin tryptic peptides by prior Accell ion-exchange column chromatography.	Peptides	80-88	thyroglobulin	Homo sapiens	58-71
3378632-1	1988	The isolation and purification of the peptides containing the hormonogenic tyrosyl residues in thyroglobulin is of great interest to the understanding of structure-function relationships in this iodoprotein.	cyclo(tyrosyl-tyrosyl)	75-82	thyroglobulin	Homo sapiens	95-108
2835260-8	1988	A significant correlation between the increased TG mRNA transcription and cAMP production was observed with Graves" IgG.	Cyclic AMP	74-78	thyroglobulin	Homo sapiens	48-50
2835260-9	1988	Thus the activation of the TG gene by Graves" IgG occurs in parallel with elevation of cAMP.	Cyclic AMP	87-91	thyroglobulin	Homo sapiens	27-29
3396754-0	1988	Colorimetry of dehydroalanine residues preserved as "lost side chains" in thyroglobulin.	dehydroalanine	15-29	thyroglobulin	Homo sapiens	74-87
3410144-3	1988	The iodine content of Tg was significantly higher in nodular tissue compared with periphery tissue.	Iodine	4-10	thyroglobulin	Homo sapiens	22-24
3410144-5	1988	On the nature of carbohydrate moiety as compared with normal tissue, oligosaccharides of Tg from the periphery tissues changed in a manner similar to that of tumor oligosaccharides.	Carbohydrates	17-29	thyroglobulin	Homo sapiens	89-91
3410144-5	1988	On the nature of carbohydrate moiety as compared with normal tissue, oligosaccharides of Tg from the periphery tissues changed in a manner similar to that of tumor oligosaccharides.	Oligosaccharides	69-85	thyroglobulin	Homo sapiens	89-91
3396754-1	1988	We developed a new assay method for dehydroalanine residues in thyroglobulin, which had been proposed to be the "lost side chains" during thyroid hormonogenesis.	dehydroalanine	36-50	thyroglobulin	Homo sapiens	63-76
3396754-2	1988	Thyroglobulin preparations were labeled with 4-aminothiophenol at 30 degrees C for 10 days.	4-aminothiophenol	45-62	thyroglobulin	Homo sapiens	0-13
3396754-7	1988	The results indicate that when one hormone residue is produced by the coupling of two iodotyrosine residues, the "lost side chain" is preserved as one dehydroalanine residue in the thyroglobulin molecule.	Monoiodotyrosine	86-98	thyroglobulin	Homo sapiens	181-194
3396754-7	1988	The results indicate that when one hormone residue is produced by the coupling of two iodotyrosine residues, the "lost side chain" is preserved as one dehydroalanine residue in the thyroglobulin molecule.	dehydroalanine	151-165	thyroglobulin	Homo sapiens	181-194
3276396-3	1988	Sensitivity of TG for the detection of metastases amounted to 83% under TSH stimulation and 50% under thyroxine (T4) treatment.	Thyrotropin	72-75	thyroglobulin	Homo sapiens	15-17
3358095-0	1988	Sensitive assay for thyroglobulin autoantibodies in serum employing polyethylene glycol for precipitation.	Polyethylene Glycols	68-87	thyroglobulin	Homo sapiens	20-33
3276396-3	1988	Sensitivity of TG for the detection of metastases amounted to 83% under TSH stimulation and 50% under thyroxine (T4) treatment.	Thyroxine	102-111	thyroglobulin	Homo sapiens	15-17
2828506-4	1988	Cholera toxin and 8-chloro-cyclic AMP increased the thyroglobulin mRNA content and thyroglobulin synthesis rate in the same ratio (approximately 3) as did thyrotrophin, showing that cyclic AMP mediates the effect of thyrotrophin on thyroglobulin gene expression.	8-chloro-cyclic adenosine monophosphate	18-37	thyroglobulin	Homo sapiens	52-65
3144412-1	1988	Normally iodinated thyroglobulin (Tg) contains low molecular weight hormone-rich peptides associated to the bulk of the molecule by disulfide bridges.	Disulfides	132-141	thyroglobulin	Homo sapiens	19-32
3144412-1	1988	Normally iodinated thyroglobulin (Tg) contains low molecular weight hormone-rich peptides associated to the bulk of the molecule by disulfide bridges.	Disulfides	132-141	thyroglobulin	Homo sapiens	34-36
3144412-2	1988	It is shown, with the assistance of in vitro iodination experiments using different iodine concentrations and various incubation times, that the proteolytic cleavage giving rise to the 26 K hormonopeptide in human Tg is part of a coupling reaction rather than iodination.	Iodine	84-90	thyroglobulin	Homo sapiens	214-216
2828506-0	1988	Thyrotrophin and cyclic AMP regulation of thyroglobulin gene expression in cultured porcine thyroid cells.	Cyclic AMP	17-27	thyroglobulin	Homo sapiens	42-55
2828506-1	1988	The effects of thyrotrophin, cholera toxin and 8-chloro-cyclic AMP on thyroglobulin gene expression in cultured porcine thyroid cells were compared.	8-chloro-cyclic adenosine monophosphate	47-66	thyroglobulin	Homo sapiens	70-83
3353172-6	1988	In nine treated children aged more than 2 yr, thyroid-stimulating hormone and Tg were increased after a brief period of decreased L-thyroxine dosage.	Thyroxine	130-141	thyroglobulin	Homo sapiens	78-80
2828506-4	1988	Cholera toxin and 8-chloro-cyclic AMP increased the thyroglobulin mRNA content and thyroglobulin synthesis rate in the same ratio (approximately 3) as did thyrotrophin, showing that cyclic AMP mediates the effect of thyrotrophin on thyroglobulin gene expression.	8-chloro-cyclic adenosine monophosphate	18-37	thyroglobulin	Homo sapiens	83-96
3361076-0	1988	Suppression of thyroglobulin secretion in amiodarone iodine-induced thyrotoxicosis.	amiodarone iodine	42-59	thyroglobulin	Homo sapiens	15-28
2828506-4	1988	Cholera toxin and 8-chloro-cyclic AMP increased the thyroglobulin mRNA content and thyroglobulin synthesis rate in the same ratio (approximately 3) as did thyrotrophin, showing that cyclic AMP mediates the effect of thyrotrophin on thyroglobulin gene expression.	8-chloro-cyclic adenosine monophosphate	18-37	thyroglobulin	Homo sapiens	83-96
2828506-4	1988	Cholera toxin and 8-chloro-cyclic AMP increased the thyroglobulin mRNA content and thyroglobulin synthesis rate in the same ratio (approximately 3) as did thyrotrophin, showing that cyclic AMP mediates the effect of thyrotrophin on thyroglobulin gene expression.	Cyclic AMP	27-37	thyroglobulin	Homo sapiens	52-65
2828506-4	1988	Cholera toxin and 8-chloro-cyclic AMP increased the thyroglobulin mRNA content and thyroglobulin synthesis rate in the same ratio (approximately 3) as did thyrotrophin, showing that cyclic AMP mediates the effect of thyrotrophin on thyroglobulin gene expression.	Cyclic AMP	27-37	thyroglobulin	Homo sapiens	83-96
2828506-4	1988	Cholera toxin and 8-chloro-cyclic AMP increased the thyroglobulin mRNA content and thyroglobulin synthesis rate in the same ratio (approximately 3) as did thyrotrophin, showing that cyclic AMP mediates the effect of thyrotrophin on thyroglobulin gene expression.	Cyclic AMP	27-37	thyroglobulin	Homo sapiens	83-96
3595540-0	1987	Digestion of thyroglobulin with purified thyroid lysosomes: preferential release of iodoamino acids.	iodoamino acids	84-99	thyroglobulin	Homo sapiens	13-26
3685869-1	1987	A new thyroglobulin (Tg) assay employing polyethylene glycol (PEG) for separation of free and antibody bound [125I]Tg is described.	Polyethylene Glycols	41-60	thyroglobulin	Homo sapiens	6-19
3685869-1	1987	A new thyroglobulin (Tg) assay employing polyethylene glycol (PEG) for separation of free and antibody bound [125I]Tg is described.	Polyethylene Glycols	41-60	thyroglobulin	Homo sapiens	21-23
3685869-1	1987	A new thyroglobulin (Tg) assay employing polyethylene glycol (PEG) for separation of free and antibody bound [125I]Tg is described.	Polyethylene Glycols	41-60	thyroglobulin	Homo sapiens	115-117
3685869-1	1987	A new thyroglobulin (Tg) assay employing polyethylene glycol (PEG) for separation of free and antibody bound [125I]Tg is described.	Polyethylene Glycols	62-65	thyroglobulin	Homo sapiens	6-19
3685869-1	1987	A new thyroglobulin (Tg) assay employing polyethylene glycol (PEG) for separation of free and antibody bound [125I]Tg is described.	Polyethylene Glycols	62-65	thyroglobulin	Homo sapiens	21-23
3685869-1	1987	A new thyroglobulin (Tg) assay employing polyethylene glycol (PEG) for separation of free and antibody bound [125I]Tg is described.	Polyethylene Glycols	62-65	thyroglobulin	Homo sapiens	115-117
3685869-2	1987	By choosing a suitable PEG concentration the non-specific precipitation of free [125I]Tg was kept low while both [125I]Tg bound to rabbit anti-Tg immunoglobulins and to human Tg autoantibodies were precipitated.	Polyethylene Glycols	23-26	thyroglobulin	Homo sapiens	86-88
3685869-2	1987	By choosing a suitable PEG concentration the non-specific precipitation of free [125I]Tg was kept low while both [125I]Tg bound to rabbit anti-Tg immunoglobulins and to human Tg autoantibodies were precipitated.	Polyethylene Glycols	23-26	thyroglobulin	Homo sapiens	119-121
3685869-2	1987	By choosing a suitable PEG concentration the non-specific precipitation of free [125I]Tg was kept low while both [125I]Tg bound to rabbit anti-Tg immunoglobulins and to human Tg autoantibodies were precipitated.	Polyethylene Glycols	23-26	thyroglobulin	Homo sapiens	119-121
3685869-2	1987	By choosing a suitable PEG concentration the non-specific precipitation of free [125I]Tg was kept low while both [125I]Tg bound to rabbit anti-Tg immunoglobulins and to human Tg autoantibodies were precipitated.	Polyethylene Glycols	23-26	thyroglobulin	Homo sapiens	119-121
3681445-0	1987	Therapeutic doses of iodine-131 reveal undiagnosed metastases in thyroid cancer patients with detectable serum thyroglobulin levels.	Iodine-131	21-31	thyroglobulin	Homo sapiens	111-124
3312242-6	1987	Labeled Tg was measured by double immunoprecipitation and by fluorography of polyacrylamide gel electrophoresis.	polyacrylamide	77-91	thyroglobulin	Homo sapiens	8-10
3312242-11	1987	It was stimulated threefold by TSH, increasing the Tg concentration in the apical compartment of the stimulated cell layer.	Thyrotropin	31-34	thyroglobulin	Homo sapiens	51-53
3427792-0	1987	Effect of prednisolone and salicylate on serum thyroglobulin level in patients with subacute thyroiditis.	Prednisolone	10-22	thyroglobulin	Homo sapiens	47-60
3427792-0	1987	Effect of prednisolone and salicylate on serum thyroglobulin level in patients with subacute thyroiditis.	Salicylates	27-37	thyroglobulin	Homo sapiens	47-60
3427792-3	1987	The serum levels of thyroglobulin (Tg) were elevated in both groups treated with salicylate and prednisolone (252 +/- SD 117 ng/ml and 233 +/- SD 157 ng/ml, respectively) at initial examination.	Salicylates	81-91	thyroglobulin	Homo sapiens	20-33
3427792-3	1987	The serum levels of thyroglobulin (Tg) were elevated in both groups treated with salicylate and prednisolone (252 +/- SD 117 ng/ml and 233 +/- SD 157 ng/ml, respectively) at initial examination.	Salicylates	81-91	thyroglobulin	Homo sapiens	35-37
3427792-3	1987	The serum levels of thyroglobulin (Tg) were elevated in both groups treated with salicylate and prednisolone (252 +/- SD 117 ng/ml and 233 +/- SD 157 ng/ml, respectively) at initial examination.	Prednisolone	96-108	thyroglobulin	Homo sapiens	20-33
3427792-3	1987	The serum levels of thyroglobulin (Tg) were elevated in both groups treated with salicylate and prednisolone (252 +/- SD 117 ng/ml and 233 +/- SD 157 ng/ml, respectively) at initial examination.	Prednisolone	96-108	thyroglobulin	Homo sapiens	35-37
3427792-4	1987	The serum level of Tg declined during the early phase with prednisolone treatment, and it reached normal values at the end of the early phase (17 +/- SD 15 ng/ml).	Prednisolone	59-71	thyroglobulin	Homo sapiens	19-21
3427792-5	1987	With salicylate treatment, the decline of levels of Tg was delayed and it was elevated (80 +/- SD 34 ng/ml) despite normal levels of thyroid hormones and ESR at the end of early phase.	Salicylates	5-15	thyroglobulin	Homo sapiens	52-54
3427792-6	1987	The serum level of Tg at the end of the early phase of prednisolone treated was significantly lower than that of salicylate treatment (P less than 0.01).	Prednisolone	55-67	thyroglobulin	Homo sapiens	19-21
3427792-7	1987	It is suggested that the effect of prednisolone on rapid decrease of Tg may be related to its inhibitory action of intrathyroid hydrolysis.	Prednisolone	35-47	thyroglobulin	Homo sapiens	69-71
3315639-4	1987	However, a positive correlation was observed between serum concentrations of Tg and thyroid stimulating hormone (TSH).	Thyrotropin	84-111	thyroglobulin	Homo sapiens	77-79
3315639-4	1987	However, a positive correlation was observed between serum concentrations of Tg and thyroid stimulating hormone (TSH).	Thyrotropin	113-116	thyroglobulin	Homo sapiens	77-79
3595540-1	1987	[131I]Thyroglobulin [( 131I]Tg), prepared by either enzymatic iodination of human goiter Tg in vitro or isolation from the thyroids of rats previously injected with 131I, was digested with a solubilized enzyme mixture prepared from purified hog thyroid lysosomes.	Thioguanine	28-30	thyroglobulin	Homo sapiens	6-19
3595540-1	1987	[131I]Thyroglobulin [( 131I]Tg), prepared by either enzymatic iodination of human goiter Tg in vitro or isolation from the thyroids of rats previously injected with 131I, was digested with a solubilized enzyme mixture prepared from purified hog thyroid lysosomes.	Thioguanine	89-91	thyroglobulin	Homo sapiens	6-19
3595540-1	1987	[131I]Thyroglobulin [( 131I]Tg), prepared by either enzymatic iodination of human goiter Tg in vitro or isolation from the thyroids of rats previously injected with 131I, was digested with a solubilized enzyme mixture prepared from purified hog thyroid lysosomes.	Iodine-131	1-5	thyroglobulin	Homo sapiens	6-19
3628022-0	1987	[131I-accumulating pulmonary and bone metastases of differentiated thyroid cancer with low serum thyroglobulin levels--an exception in tumor follow-up?].	Iodine-131	1-5	thyroglobulin	Homo sapiens	97-110
3628022-2	1987	A positive 131I scan of metastases in the follow-up of patients with differentiated thyroid carcinoma combined with a low serum thyroglobulin level is extremely rare.	Iodine-131	11-15	thyroglobulin	Homo sapiens	128-141
3808965-1	1986	Monoclonal mouse antibodies to human thyroglobulin were conjugated to the cyclic dianhydride of DTPA.	cyclic dianhydride	74-92	thyroglobulin	Homo sapiens	37-50
3558731-0	1987	Thyroxine and 3,5,3"-triiodothyronine content of thyroglobulin in thyroid needle aspirates in hyperthyroidism and hypothyroidism.	3,5,3"-triiodothyronine	14-37	thyroglobulin	Homo sapiens	49-62
3558731-4	1987	The iodothyronine content of Tg was, normal, T4 3.7 +/- 0.5 mol/mol, T3 0.28 +/- 0.04 mol/mol, T4/T3 13.7 +/- 1.4; hyperthyroidism, T4 3.8 +/- 1.0, T3 0.59 +/- 0.15, T4/T3 6.8 +/- 1.1; hypothyroidism, T4 3.3 +/- 0.5, T3 0.54 +/- 0.09, T4/T3 6.8 +/- 0.7.	iodothyronine	4-17	thyroglobulin	Homo sapiens	29-31
3558731-5	1987	The iodine content of Tg was 28 +/- 3.1 atoms/mol in the euthyroid subjects and 31 +/- 7.3 atoms/mol in hyperthyroid patients.	Iodine	4-10	thyroglobulin	Homo sapiens	22-24
2832304-0	1987	Control of thyroglobulin gene transcription by TSH and cAMP.	Thyrotropin	47-50	thyroglobulin	Homo sapiens	11-24
2832304-0	1987	Control of thyroglobulin gene transcription by TSH and cAMP.	Cyclic AMP	55-59	thyroglobulin	Homo sapiens	11-24
3568096-4	1987	The secretion of 3H-leucine-labeled thyroglobulin decreased linearly between 37 degrees and 20 degrees C; within this temperature range the activation energy for secretion, calculated from Arrhenius plots, was found to be 37 kcal/mol.	Tritium	17-19	thyroglobulin	Homo sapiens	36-49
3539312-1	1987	The effectiveness of an immunoperoxidase technique using four monoclonal antibodies (mAb) is compared to a technique using one polyclonal antibody (pAb) to detect human thyroglobulin (Tg) in paraffin sections of 55 thyroid carcinomas.	Paraffin	191-199	thyroglobulin	Homo sapiens	169-182
3539312-1	1987	The effectiveness of an immunoperoxidase technique using four monoclonal antibodies (mAb) is compared to a technique using one polyclonal antibody (pAb) to detect human thyroglobulin (Tg) in paraffin sections of 55 thyroid carcinomas.	Paraffin	191-199	thyroglobulin	Homo sapiens	184-186
3808965-1	1986	Monoclonal mouse antibodies to human thyroglobulin were conjugated to the cyclic dianhydride of DTPA.	Pentetic Acid	96-100	thyroglobulin	Homo sapiens	37-50
3782813-5	1986	3-Azido-N-ethylcarbazole (ANEC), the azido analog of 3-amino-N-ethylcarbazole, was conjugated to bovine serum albumin (BSA), human transferrin (TR), thyroglobulin (TH), poly-(lysine X tyrosine), and poly-(lysine X phenylalanine) using standard photolabeling procedures.	3-amino-9-ethylcarbazole	53-77	thyroglobulin	Homo sapiens	149-162
3782813-5	1986	3-Azido-N-ethylcarbazole (ANEC), the azido analog of 3-amino-N-ethylcarbazole, was conjugated to bovine serum albumin (BSA), human transferrin (TR), thyroglobulin (TH), poly-(lysine X tyrosine), and poly-(lysine X phenylalanine) using standard photolabeling procedures.	3-azido-N-ethylcarbazole	0-24	thyroglobulin	Homo sapiens	149-162
3698909-0	1986	Evidence, by in vitro enzymatic iodination of thyroglobulin, that the efficiency of coupling is determined by the initial iodide concentration.	Iodides	122-128	thyroglobulin	Homo sapiens	46-59
3782813-5	1986	3-Azido-N-ethylcarbazole (ANEC), the azido analog of 3-amino-N-ethylcarbazole, was conjugated to bovine serum albumin (BSA), human transferrin (TR), thyroglobulin (TH), poly-(lysine X tyrosine), and poly-(lysine X phenylalanine) using standard photolabeling procedures.	3-azido-N-ethylcarbazole	26-30	thyroglobulin	Homo sapiens	149-162
3745406-2	1986	The association of clinical and biological hypothyroidism with undetectable levels of serum thyroglobulin (Tg) and the presence of iodohistidines in the urine suggested the diagnosis of defective Tg gene expression.	iodohistidines	131-145	thyroglobulin	Homo sapiens	196-198
3745406-4	1986	Only minute amounts of Tg-related material was detected by RIA (0.28 and 0.17 mg/g tissue compared to 80-100 mg/g in normal thyroid tissue), by Sepharose 6B chromatography, and by sucrose density gradient centrifugation.	sepharose 6b	144-156	thyroglobulin	Homo sapiens	23-25
3745406-4	1986	Only minute amounts of Tg-related material was detected by RIA (0.28 and 0.17 mg/g tissue compared to 80-100 mg/g in normal thyroid tissue), by Sepharose 6B chromatography, and by sucrose density gradient centrifugation.	Sucrose	180-187	thyroglobulin	Homo sapiens	23-25
3726442-1	1986	Iodothyronine and iodine contents of Tg from patients with multinodular euthyroid goitre.	iodothyronine	0-13	thyroglobulin	Homo sapiens	37-39
3726442-1	1986	Iodothyronine and iodine contents of Tg from patients with multinodular euthyroid goitre.	Iodine	18-24	thyroglobulin	Homo sapiens	37-39
3726442-6	1986	Similar values were obtained if iodine and iodothyronines were measured in crude aspirate (after alkaline ashing and pronase hydrolysis, respectively) and related to the amount of Tg in aspirate measured by radioimmunoassay; thus avoiding the cumbersome purification of Tg.	Iodine	32-38	thyroglobulin	Homo sapiens	180-182
3726442-6	1986	Similar values were obtained if iodine and iodothyronines were measured in crude aspirate (after alkaline ashing and pronase hydrolysis, respectively) and related to the amount of Tg in aspirate measured by radioimmunoassay; thus avoiding the cumbersome purification of Tg.	iodothyronines	43-57	thyroglobulin	Homo sapiens	180-182
2878948-2	1986	Four h after start of the beta blockade median serum thyroglobulin (Tg) had decreased to 33 (range: 13-325) micrograms/l from 41 (range: 12-333) micrograms/l before start in the acebutolol treated group (p less than 0.05).	Acebutolol	178-188	thyroglobulin	Homo sapiens	53-66
2878948-3	1986	A significant decrease in serum Tg was also found in the oxprenolol-treated group [before start: 45 (24-423) micrograms/l and after 4h: 43 (18-363) micrograms/l (p less than 0.01)] and in the pindolol-treated group [before start: 154 (33-210) micrograms/l and after 4 h: 63 (19-157) micrograms/l (p less than 0.05) treated groups.	Oxprenolol	57-67	thyroglobulin	Homo sapiens	32-34
2878948-3	1986	A significant decrease in serum Tg was also found in the oxprenolol-treated group [before start: 45 (24-423) micrograms/l and after 4h: 43 (18-363) micrograms/l (p less than 0.01)] and in the pindolol-treated group [before start: 154 (33-210) micrograms/l and after 4 h: 63 (19-157) micrograms/l (p less than 0.05) treated groups.	4h	132-134	thyroglobulin	Homo sapiens	32-34
2878948-3	1986	A significant decrease in serum Tg was also found in the oxprenolol-treated group [before start: 45 (24-423) micrograms/l and after 4h: 43 (18-363) micrograms/l (p less than 0.01)] and in the pindolol-treated group [before start: 154 (33-210) micrograms/l and after 4 h: 63 (19-157) micrograms/l (p less than 0.05) treated groups.	Pindolol	192-200	thyroglobulin	Homo sapiens	32-34
2878948-4	1986	After 7 days treatment the decrease in serum Tg was significant [to 85 (34-182) micrograms/l (p less than 0.02)] only in the Pindolol-treated group.	Pindolol	125-133	thyroglobulin	Homo sapiens	45-47
3539581-0	1986	Analysis of thyroglobulin antibody synthesis by cultured peripheral blood lymphocytes from patients with Hashimoto"s thyroiditis using biotin-avidin solid phase enzyme immuno-assay.	Biotin	135-141	thyroglobulin	Homo sapiens	12-25
3024868-0	1986	Long-term effect of iodized oil on serum thyroglobulin levels in endemic goitre patients.	Oils	28-31	thyroglobulin	Homo sapiens	41-54
3698909-9	1986	Provided that initially nonlimiting noninhibiting H2O2 and iodide concentrations are used and that iodination and coupling are allowed to proceed to completion, the extent of coupling is a function of the degree of iodination of Tgb achieved, and its efficiency is determined not just by the native structure of Tgb, but also by the initial iodide concentration used.	Hydrogen Peroxide	50-54	thyroglobulin	Homo sapiens	229-232
3698909-9	1986	Provided that initially nonlimiting noninhibiting H2O2 and iodide concentrations are used and that iodination and coupling are allowed to proceed to completion, the extent of coupling is a function of the degree of iodination of Tgb achieved, and its efficiency is determined not just by the native structure of Tgb, but also by the initial iodide concentration used.	Iodides	59-65	thyroglobulin	Homo sapiens	229-232
3698909-9	1986	Provided that initially nonlimiting noninhibiting H2O2 and iodide concentrations are used and that iodination and coupling are allowed to proceed to completion, the extent of coupling is a function of the degree of iodination of Tgb achieved, and its efficiency is determined not just by the native structure of Tgb, but also by the initial iodide concentration used.	Iodides	341-347	thyroglobulin	Homo sapiens	229-232
3935423-0	1985	Thyroglobulin and thyroid hormones in patients on long-term treatment with phenytoin, carbamazepine, and valproic acid.	Phenytoin	75-84	thyroglobulin	Homo sapiens	0-13
3941162-0	1986	Serum thyroglobulin levels are elevated in newborns from iodine-deficient areas.	Iodine	57-63	thyroglobulin	Homo sapiens	6-19
3941162-3	1986	In the iodine-sufficient area, the mean cord serum Tg level was 25.8 ng/ml (median, 18.0; n = 183).	Iodine	7-13	thyroglobulin	Homo sapiens	51-53
3941162-4	1986	In the iodine-deficient areas, the serum Tg levels in newborns were significantly higher, with mean levels of 43.4 ng/ml (median, 29.7; n = 304; P less than 0.01) and 60.1 ng/ml (median, 48.0; n = 212; P less than 0.005), respectively.	Iodine	7-13	thyroglobulin	Homo sapiens	41-43
3941162-5	1986	The higher serum Tg level at birth was not entirely due to increased cord serum TSH levels, since newborns from the iodine-deficient areas with serum TSH levels at birth similar to those in infants from the control area had higher serum Tg levels.	Iodine	116-122	thyroglobulin	Homo sapiens	17-19
3941162-5	1986	The higher serum Tg level at birth was not entirely due to increased cord serum TSH levels, since newborns from the iodine-deficient areas with serum TSH levels at birth similar to those in infants from the control area had higher serum Tg levels.	Iodine	116-122	thyroglobulin	Homo sapiens	237-239
3941162-5	1986	The higher serum Tg level at birth was not entirely due to increased cord serum TSH levels, since newborns from the iodine-deficient areas with serum TSH levels at birth similar to those in infants from the control area had higher serum Tg levels.	Thyrotropin	150-153	thyroglobulin	Homo sapiens	17-19
3941162-7	1986	These data suggest that iodine availability, which affects the degree of thyroid Tg iodination, partially determines serum Tg levels at birth.	Iodine	24-30	thyroglobulin	Homo sapiens	81-83
3941162-7	1986	These data suggest that iodine availability, which affects the degree of thyroid Tg iodination, partially determines serum Tg levels at birth.	Iodine	24-30	thyroglobulin	Homo sapiens	123-125
2430684-1	1986	Thyroglobulin (Tg), isolated from soluble iodoproteins by ammonium sulphate fractionation, was enzymatically deglycosylated in vitro and analyzed by polyacrylamide gel electrophoresis, double immunodiffusion and non-commercial RIA.	Ammonium Sulfate	58-75	thyroglobulin	Homo sapiens	0-13
2430684-1	1986	Thyroglobulin (Tg), isolated from soluble iodoproteins by ammonium sulphate fractionation, was enzymatically deglycosylated in vitro and analyzed by polyacrylamide gel electrophoresis, double immunodiffusion and non-commercial RIA.	Ammonium Sulfate	58-75	thyroglobulin	Homo sapiens	15-17
2430684-1	1986	Thyroglobulin (Tg), isolated from soluble iodoproteins by ammonium sulphate fractionation, was enzymatically deglycosylated in vitro and analyzed by polyacrylamide gel electrophoresis, double immunodiffusion and non-commercial RIA.	polyacrylamide	149-163	thyroglobulin	Homo sapiens	0-13
2430684-1	1986	Thyroglobulin (Tg), isolated from soluble iodoproteins by ammonium sulphate fractionation, was enzymatically deglycosylated in vitro and analyzed by polyacrylamide gel electrophoresis, double immunodiffusion and non-commercial RIA.	polyacrylamide	149-163	thyroglobulin	Homo sapiens	15-17
2430684-3	1986	By PAAGE deglycosylated Tg (dTg) showed the appearance of a major band in the 12S region and three slower migrating bands corresponding to higher aggregates than 19S Tg.	1-(4-azido-2-methylphenyl)-3-(2-methylphenyl)guanidine	28-31	thyroglobulin	Homo sapiens	24-26
2430684-6	1986	The results demonstrate that the enzymatic deglycosylation release almost all the carbohydrates of goiter Tg and that the removal of the carbohydrates of Tg produces a loss of antigenic determinants of the molecule.	Carbohydrates	82-95	thyroglobulin	Homo sapiens	106-108
3956516-5	1986	Digestion of 35-SO4(2-)-thyroglobulin with endoglycosidase H removes 20 to 30% of the radioactivity, indicating that the high mannose carbohydrate side chains carry sulfate residues.	mannose carbohydrate	126-146	thyroglobulin	Homo sapiens	24-37
3956516-5	1986	Digestion of 35-SO4(2-)-thyroglobulin with endoglycosidase H removes 20 to 30% of the radioactivity, indicating that the high mannose carbohydrate side chains carry sulfate residues.	Sulfates	165-172	thyroglobulin	Homo sapiens	24-37
3956516-8	1986	Part of the sulfate is exposed and presumably located on the surface of the thyroglobulin molecule as suggested by the direct accessibility of 35-SO4(2-)-thyroglobulin to digestion with sulfatases.	Sulfates	12-19	thyroglobulin	Homo sapiens	76-89
3956516-8	1986	Part of the sulfate is exposed and presumably located on the surface of the thyroglobulin molecule as suggested by the direct accessibility of 35-SO4(2-)-thyroglobulin to digestion with sulfatases.	Sulfates	12-19	thyroglobulin	Homo sapiens	154-167
3956516-8	1986	Part of the sulfate is exposed and presumably located on the surface of the thyroglobulin molecule as suggested by the direct accessibility of 35-SO4(2-)-thyroglobulin to digestion with sulfatases.	35-so4	143-149	thyroglobulin	Homo sapiens	76-89
3956516-8	1986	Part of the sulfate is exposed and presumably located on the surface of the thyroglobulin molecule as suggested by the direct accessibility of 35-SO4(2-)-thyroglobulin to digestion with sulfatases.	35-so4	143-149	thyroglobulin	Homo sapiens	154-167
3956516-9	1986	The sulfate residues contribute to the anionic state of thyroglobulin.	Sulfates	4-11	thyroglobulin	Homo sapiens	56-69
3956516-10	1986	It is postulated that the sulfate residues operate in the regulation of thyroglobulin transport in the cell and in the tight packaging of thyroglobulin in the follicle lumen.	Sulfates	26-33	thyroglobulin	Homo sapiens	72-85
3956516-10	1986	It is postulated that the sulfate residues operate in the regulation of thyroglobulin transport in the cell and in the tight packaging of thyroglobulin in the follicle lumen.	Sulfates	26-33	thyroglobulin	Homo sapiens	138-151
3084458-2	1986	Treatment with steroids, propylthiouracil, propranolol, iodine, and plasmapheresis was associated with dramatic reduction in serum triiodothyronine (T3), serum thyroxine (T4), and thyroglobulin levels and prompt recovery of the patient.	Steroids	15-23	thyroglobulin	Homo sapiens	180-193
3084458-2	1986	Treatment with steroids, propylthiouracil, propranolol, iodine, and plasmapheresis was associated with dramatic reduction in serum triiodothyronine (T3), serum thyroxine (T4), and thyroglobulin levels and prompt recovery of the patient.	Propylthiouracil	25-41	thyroglobulin	Homo sapiens	180-193
3084458-2	1986	Treatment with steroids, propylthiouracil, propranolol, iodine, and plasmapheresis was associated with dramatic reduction in serum triiodothyronine (T3), serum thyroxine (T4), and thyroglobulin levels and prompt recovery of the patient.	Propranolol	43-54	thyroglobulin	Homo sapiens	180-193
3084458-2	1986	Treatment with steroids, propylthiouracil, propranolol, iodine, and plasmapheresis was associated with dramatic reduction in serum triiodothyronine (T3), serum thyroxine (T4), and thyroglobulin levels and prompt recovery of the patient.	Iodine	56-62	thyroglobulin	Homo sapiens	180-193
3910759-7	1985	The effect of L-thyroxine on the suppression of serum thyroglobulin levels appeared to be dose-dependent, as newborns from experimental criterium group a) (defined above) showed no suppression of serum thyroglobulin levels when under partial substitution with L-thyroxine (median 84 micrograms/l), whereas those in group b), i.e. with full L-thyroxine substitution showed a noticeable suppression of serum thyroglobulin (median 27 micrograms/l).	Thyroxine	14-25	thyroglobulin	Homo sapiens	54-67
3935423-0	1985	Thyroglobulin and thyroid hormones in patients on long-term treatment with phenytoin, carbamazepine, and valproic acid.	Carbamazepine	86-99	thyroglobulin	Homo sapiens	0-13
3935423-0	1985	Thyroglobulin and thyroid hormones in patients on long-term treatment with phenytoin, carbamazepine, and valproic acid.	Valproic Acid	105-118	thyroglobulin	Homo sapiens	0-13
2998424-4	1985	Elevated serum Tg (patient taking T4 in suppressive dose) was generally associated with tumours which had 131I concentrating function when stimulated by excess TSH.	Thyrotropin	160-163	thyroglobulin	Homo sapiens	15-17
4064348-8	1985	These Tg results were confirmed to be truly rather than falsely positive, since evidence of metastatic disease was obtained by whole body scan after the administration of therapeutic doses of 131I.	Iodine-131	192-196	thyroglobulin	Homo sapiens	6-8
3838997-6	1985	Before the coupling reaction, thyroglobulin was iodinated with chloramine-T and potassium iodide, followed by dialysis.	chloramine-T	63-75	thyroglobulin	Homo sapiens	30-43
4053410-1	1985	Subjects living in iodine deficient areas were reported to have elevated serum thyroglobulin (Tg) concentrations.	Iodine	19-25	thyroglobulin	Homo sapiens	79-92
4053410-1	1985	Subjects living in iodine deficient areas were reported to have elevated serum thyroglobulin (Tg) concentrations.	Iodine	19-25	thyroglobulin	Homo sapiens	94-96
4053410-3	1985	Discrepant results, however, were found when serum Tg concentrations were correlated either with serum TSH or with goitre size.	Thyrotropin	103-106	thyroglobulin	Homo sapiens	51-53
3838997-4	1985	Thyroglobulin with low thyroid hormone content was obtained from Grave"s and follicular adenoma tissues after propylthiouracil (PTU) therapy and L-T4 therapy, respectively.	Propylthiouracil	110-126	thyroglobulin	Homo sapiens	0-13
3838997-4	1985	Thyroglobulin with low thyroid hormone content was obtained from Grave"s and follicular adenoma tissues after propylthiouracil (PTU) therapy and L-T4 therapy, respectively.	Propylthiouracil	128-131	thyroglobulin	Homo sapiens	0-13
4086465-3	1985	The correlation between the Mini assay and Ordinary assay methods, and between the guaiacol and iodide assays by both methods were satisfactorily good, but the iodine content of thyroglobulin was found to be not directly correlated to the peroxidase activities.	Iodine	160-166	thyroglobulin	Homo sapiens	178-191
2991855-0	1985	An unusually long poly(purine)-poly(pyrimidine) sequence is located upstream from the human thyroglobulin gene.	poly(purine)	18-30	thyroglobulin	Homo sapiens	92-105
2991855-0	1985	An unusually long poly(purine)-poly(pyrimidine) sequence is located upstream from the human thyroglobulin gene.	poly(pyrimidine)	31-47	thyroglobulin	Homo sapiens	92-105
4028462-0	1985	Relationship between serum thyroglobulin and intrathyroidal stable iodine in human simple goitre.	Iodine	67-73	thyroglobulin	Homo sapiens	27-40
4028462-3	1985	To test the hypothesis that increased serum Tg could be related to the low intrathyroidal iodine concentration [I], the main cause of nontoxic goitre, these two variables were measured in 91 euthyroid goitrous patients and compared to serum free T3 and free T4 levels as well as thyroid weight.	Iodine	90-96	thyroglobulin	Homo sapiens	44-46
4028462-7	1985	These data suggest that, in simple goitre, increased serum Tg concentrations are partly related to the reduced concentration of iodine in goitre tissue (as are an increased T3/T4 ratio and the size of the goitre) and is not only the reflection of follicular necrosis.	Iodine	128-134	thyroglobulin	Homo sapiens	59-61
3838997-4	1985	Thyroglobulin with low thyroid hormone content was obtained from Grave"s and follicular adenoma tissues after propylthiouracil (PTU) therapy and L-T4 therapy, respectively.	Thyroxine	145-149	thyroglobulin	Homo sapiens	0-13
3838997-6	1985	Before the coupling reaction, thyroglobulin was iodinated with chloramine-T and potassium iodide, followed by dialysis.	Potassium Iodide	80-96	thyroglobulin	Homo sapiens	30-43
3838997-7	1985	The coupling reaction was carried out by incubating newly iodinated thyroglobulin with TPO, diiodotyrosine, a coupling stimulator, and a H2O2-generating system (glucose and glucose oxidase) for 20 min at 37 C. After thyroglobulin was digested with Pronase, the thyroid hormone content of the thyroid digest was measured by RIA.	Diiodotyrosine	92-106	thyroglobulin	Homo sapiens	68-81
3838997-7	1985	The coupling reaction was carried out by incubating newly iodinated thyroglobulin with TPO, diiodotyrosine, a coupling stimulator, and a H2O2-generating system (glucose and glucose oxidase) for 20 min at 37 C. After thyroglobulin was digested with Pronase, the thyroid hormone content of the thyroid digest was measured by RIA.	Hydrogen Peroxide	137-141	thyroglobulin	Homo sapiens	68-81
3838997-7	1985	The coupling reaction was carried out by incubating newly iodinated thyroglobulin with TPO, diiodotyrosine, a coupling stimulator, and a H2O2-generating system (glucose and glucose oxidase) for 20 min at 37 C. After thyroglobulin was digested with Pronase, the thyroid hormone content of the thyroid digest was measured by RIA.	Glucose	161-168	thyroglobulin	Homo sapiens	68-81
3971976-7	1985	We have also demonstrated (a) the hormonogenic tyrosine residue recently described in the mature protein, which is located four amino acids after the NH2-terminal Asn; (b) a prepeptide signal of thyroglobulin secretion comprising 19 amino acids preceding the Asn residue, the NH2-terminal residue of the mature protein and (c) a six-signal tripeptide (Asn-Xaa-Thr or Ser) of N-glycosylation of the chain.	Tyrosine	47-55	thyroglobulin	Homo sapiens	195-208
4022016-10	1985	Absorption of thyroiditis sera on thyroglobulin-Sepharose followed by immunoprecipitation abolished the anti-thyroglobulin components without affecting the binding of the 105,000-dalton polypeptide, if the sera contained antimicrosomal antibody.	Sepharose	48-57	thyroglobulin	Homo sapiens	34-47
3977926-0	1985	Cross-linking with dimethylsuberimidate to study thyroglobulin conformation.	Dimethyl Suberimidate	19-39	thyroglobulin	Homo sapiens	49-62
3977926-1	1985	The present investigation demonstrates that the cross-linking agent, dimethylsuberimidate, is an usefull tool to study thyroglobulin structure.	Dimethyl Suberimidate	69-89	thyroglobulin	Homo sapiens	119-132
4004811-0	1985	Structural basis for the reaction of 3,5,3"-tri-iodothyronine-specific antibodies with thyroxine-containing thyroglobulin.	3,5,3"-tri-iodothyronine	37-61	thyroglobulin	Homo sapiens	108-121
4004811-1	1985	A series of human autoantibodies against thyroglobulin (Tg) which exhibit different specificities for iodothyronines were studied.	iodothyronines	102-116	thyroglobulin	Homo sapiens	41-54
3839103-2	1985	Iodine and iodothyronine content of Tg was determined.	iodothyronine	11-24	thyroglobulin	Homo sapiens	36-38
3839103-5	1985	The intensity of the single bands depended on the iodothyronine content of Tg.	iodothyronine	50-63	thyroglobulin	Homo sapiens	75-77
3839103-7	1985	This typical change in microheterogeneity pattern could be confirmed by kinetic in vitro iodination and consecutive iodothyronine formation of low iodinated Tg (0.05% iodine).	iodothyronine	116-129	thyroglobulin	Homo sapiens	157-159
3839103-7	1985	This typical change in microheterogeneity pattern could be confirmed by kinetic in vitro iodination and consecutive iodothyronine formation of low iodinated Tg (0.05% iodine).	Iodine	167-173	thyroglobulin	Homo sapiens	157-159
3839103-9	1985	Even in desialylated Tg microheterogeneity is still dependent on iodine content.	Iodine	65-71	thyroglobulin	Homo sapiens	21-23
3839103-12	1985	In thyroid diseases without disturbance in Tg synthesis (endemic, diffuse and nodular goitre, Graves" disease) variations in relative intensity of single bands could be related to differences in iodine content.	Iodine	195-201	thyroglobulin	Homo sapiens	43-45
3971976-7	1985	We have also demonstrated (a) the hormonogenic tyrosine residue recently described in the mature protein, which is located four amino acids after the NH2-terminal Asn; (b) a prepeptide signal of thyroglobulin secretion comprising 19 amino acids preceding the Asn residue, the NH2-terminal residue of the mature protein and (c) a six-signal tripeptide (Asn-Xaa-Thr or Ser) of N-glycosylation of the chain.	prepeptide	174-184	thyroglobulin	Homo sapiens	195-208
3971976-7	1985	We have also demonstrated (a) the hormonogenic tyrosine residue recently described in the mature protein, which is located four amino acids after the NH2-terminal Asn; (b) a prepeptide signal of thyroglobulin secretion comprising 19 amino acids preceding the Asn residue, the NH2-terminal residue of the mature protein and (c) a six-signal tripeptide (Asn-Xaa-Thr or Ser) of N-glycosylation of the chain.	Asparagine	259-262	thyroglobulin	Homo sapiens	195-208
3971976-7	1985	We have also demonstrated (a) the hormonogenic tyrosine residue recently described in the mature protein, which is located four amino acids after the NH2-terminal Asn; (b) a prepeptide signal of thyroglobulin secretion comprising 19 amino acids preceding the Asn residue, the NH2-terminal residue of the mature protein and (c) a six-signal tripeptide (Asn-Xaa-Thr or Ser) of N-glycosylation of the chain.	tripeptide K-26	340-350	thyroglobulin	Homo sapiens	195-208
3971976-7	1985	We have also demonstrated (a) the hormonogenic tyrosine residue recently described in the mature protein, which is located four amino acids after the NH2-terminal Asn; (b) a prepeptide signal of thyroglobulin secretion comprising 19 amino acids preceding the Asn residue, the NH2-terminal residue of the mature protein and (c) a six-signal tripeptide (Asn-Xaa-Thr or Ser) of N-glycosylation of the chain.	asn-xaa-thr	352-363	thyroglobulin	Homo sapiens	195-208
3971976-7	1985	We have also demonstrated (a) the hormonogenic tyrosine residue recently described in the mature protein, which is located four amino acids after the NH2-terminal Asn; (b) a prepeptide signal of thyroglobulin secretion comprising 19 amino acids preceding the Asn residue, the NH2-terminal residue of the mature protein and (c) a six-signal tripeptide (Asn-Xaa-Thr or Ser) of N-glycosylation of the chain.	Serine	367-370	thyroglobulin	Homo sapiens	195-208
3917691-0	1985	Phosphorylated high mannose-type and hybrid-type oligosaccharide chains of human thyroglobulin isolated from malignant thyroid tissue.	Mannose	20-27	thyroglobulin	Homo sapiens	81-94
4005305-0	1985	In vitro synthesis of thyroxine in a low molecular weight polypeptide fragment from human thyroglobulin.	Thyroxine	22-31	thyroglobulin	Homo sapiens	90-103
4005305-1	1985	A peptide fragment of Mr 16 K was purified from the cyanogen bromide digest of human thyroglobulin either normally iodinated in vivo (0.21 % I) or highly iodinated in vitro (1.40 % I).	Cyanogen Bromide	52-68	thyroglobulin	Homo sapiens	85-98
4005305-3	1985	In contrast, after isolation from thyroglobulin and iodination in vitro, the peptide is capable of synthesizing thyroxine with a high efficiency.	Thyroxine	112-121	thyroglobulin	Homo sapiens	34-47
4005305-4	1985	It is concluded that the peptide described which probably represents a potential hormone forming site in the whole thyroglobulin molecule should constitute a valuable model to study the mechanism of thyroxine formation in vitro.	Thyroxine	199-208	thyroglobulin	Homo sapiens	115-128
3917691-3	1985	The possible meaning of the phosphorylated oligosaccharides was discussed in relation to the low thyroglobulin content in malignant thyroid tissue.	Oligosaccharides	43-59	thyroglobulin	Homo sapiens	97-110
3917691-0	1985	Phosphorylated high mannose-type and hybrid-type oligosaccharide chains of human thyroglobulin isolated from malignant thyroid tissue.	Oligosaccharides	49-64	thyroglobulin	Homo sapiens	81-94
3917691-1	1985	Structures of anionic oligosaccharides released by endo-beta-N-acetylglucosaminidase H from human thyroglobulin (19 S) purified from normal and malignant (papillary carcinoma) thyroid tissues were studied by sequential exoglycosidase digestion and lectin affinity chromatography.	Oligosaccharides	22-38	thyroglobulin	Homo sapiens	98-111
3917691-2	1985	It was revealed that sialylated hybrid-type oligosaccharides were present in thyroglobulin from normal thyroid tissue, whereas, in the case of thyroglobulin from malignant thyroid tissue, phosphorylated high-mannose type and hybrid-type oligosaccharides each containing one phosphate group in a diester linkage were present instead of sialylated oligosaccharides.	Oligosaccharides	44-60	thyroglobulin	Homo sapiens	77-90
3917691-2	1985	It was revealed that sialylated hybrid-type oligosaccharides were present in thyroglobulin from normal thyroid tissue, whereas, in the case of thyroglobulin from malignant thyroid tissue, phosphorylated high-mannose type and hybrid-type oligosaccharides each containing one phosphate group in a diester linkage were present instead of sialylated oligosaccharides.	Mannose	208-215	thyroglobulin	Homo sapiens	143-156
6495405-2	1984	The obtained experimental data permit supposing the existence of conformation changes in a thyroglobulin molecule under the iodine deficiency.	Iodine	124-130	thyroglobulin	Homo sapiens	91-104
3987701-9	1985	Moreover, Tg levels were high in 76% of the patients with metastases unable to take up radioiodine.	Iodine-131	87-98	thyroglobulin	Homo sapiens	10-12
4006972-1	1985	A monoclonal antibody to human thyroglobulin was radiolabelled with 123I NaI and shown to be a stable and biologically active reagent in vivo.	123i nai	68-76	thyroglobulin	Homo sapiens	31-44
3967888-1	1985	The human thyroglobulin gene was mapped by in situ hybridization whereby a 3H-labeled recombinant plasmid DNA containing a fragment of 2.3 kilobases of human thyroglobulin gene was hybridized to human chromosome preparations.	Tritium	75-77	thyroglobulin	Homo sapiens	10-23
3967888-1	1985	The human thyroglobulin gene was mapped by in situ hybridization whereby a 3H-labeled recombinant plasmid DNA containing a fragment of 2.3 kilobases of human thyroglobulin gene was hybridized to human chromosome preparations.	Tritium	75-77	thyroglobulin	Homo sapiens	158-171
6468384-0	1984	Structural changes of carbohydrate chains of human thyroglobulin accompanying malignant transformations of thyroid glands.	Carbohydrates	22-34	thyroglobulin	Homo sapiens	51-64
3983096-0	1985	[Effect of cryopreservation of thyroid parenchyma on iodoamino acid composition of thyroglobulin and its iodination].	iodoamino acid	53-67	thyroglobulin	Homo sapiens	83-96
3983096-1	1985	The content and distribution of iodoamino acids in thyroglobulin of the cryopreserved thyrotoxically-changed thyroid parenchyma were studied, as was thyroglobulin iodination.	iodoamino acids	32-47	thyroglobulin	Homo sapiens	51-64
3983096-5	1985	Thyroglobulin was isolated by gel filtration of the thyroid saline extract through a column packed with Sephadex G-200.	thyroid saline	52-66	thyroglobulin	Homo sapiens	0-13
3983096-5	1985	Thyroglobulin was isolated by gel filtration of the thyroid saline extract through a column packed with Sephadex G-200.	sephadex	104-118	thyroglobulin	Homo sapiens	0-13
3983096-6	1985	Thyroglobulin was iodinated with KI + I2 water solution, pH 9.2, at 37 C for 30 min.	ki + i2	33-40	thyroglobulin	Homo sapiens	0-13
3983096-6	1985	Thyroglobulin was iodinated with KI + I2 water solution, pH 9.2, at 37 C for 30 min.	Water	41-46	thyroglobulin	Homo sapiens	0-13
3983096-9	1985	Thyroglobulin iodoamino acid composition was determined by direct spectrophotometry.	iodoamino acid	14-28	thyroglobulin	Homo sapiens	0-13
3983096-12	1985	Cryopreservation of the thyroid parenchyma considerably affected iodine incorporation and formation of iodoamino acids in the thyroglobulin during its in vitro iodination.	iodoamino acids	103-118	thyroglobulin	Homo sapiens	126-139
6479331-1	1984	At moderate iodination levels (20 iodine at atoms/molecule), human thyroglobulin (hTgb) produces after reduction a thyroxinyl-peptide of 26 kDa which represents the N-terminal part of the protein.	Iodine	34-40	thyroglobulin	Homo sapiens	67-80
6743226-0	1984	Exposure of thyroxine residues in human thyroglobulin.	Thyroxine	12-21	thyroglobulin	Homo sapiens	40-53
6732810-1	1984	Thyroglobulin of very low iodine content has been prepared from a single non-toxic human goitre.	Iodine	26-32	thyroglobulin	Homo sapiens	0-13
6475061-6	1984	TG was highest in metastatic disease and practically uninfluenced by T4, i.e. by the endogenous TSH level.	Thyrotropin	96-99	thyroglobulin	Homo sapiens	0-2
6431749-3	1984	TG was purified by differential salt fractionation and DEAE-cellulose chromatography.	DEAE-Cellulose	55-69	thyroglobulin	Homo sapiens	0-2
6531150-0	1984	Time course of thyroglobulin autoantibodies in patients with differentiated thyroid carcinoma after radioiodine therapy.	Iodine-131	100-111	thyroglobulin	Homo sapiens	15-28
6743226-2	1984	Human thyroglobulin (Tg) could be adsorbed through one of its thyroxine (T4) residues by either of two T4-binding antibodies which had been covalently attached to Sepharose- CL4B .	Thyroxine	62-71	thyroglobulin	Homo sapiens	6-19
6713694-2	1984	PAS positive material, presumably thyroglobulin, was found in the interstitial network between follicles.	Protactinium	0-3	thyroglobulin	Homo sapiens	34-47
6743226-2	1984	Human thyroglobulin (Tg) could be adsorbed through one of its thyroxine (T4) residues by either of two T4-binding antibodies which had been covalently attached to Sepharose- CL4B .	Sepharose CL 4B	163-178	thyroglobulin	Homo sapiens	6-19
6695549-0	1984	Relationship between thyroid volume and serum thyroglobulin during long-term suppression with triiodothyronine in patients with diffuse non-toxic goitre.	Triiodothyronine	94-110	thyroglobulin	Homo sapiens	46-59
6427386-2	1984	Thyroglobulin levels were invariably high in patients with iodine fixing metastases.	Iodine	59-65	thyroglobulin	Homo sapiens	0-13
6680308-2	1983	The proteolysis of thyroglobulin was performed after partial cleavage of its carbohydrate moiety.	Carbohydrates	77-89	thyroglobulin	Homo sapiens	19-32
6486614-3	1984	False negative results are rare but have been reported and therefore, it is useful to repeat Tg measurement after TSH stimulation in patients with undetectable Tg levels during T4 treatment.	Thyrotropin	114-117	thyroglobulin	Homo sapiens	160-162
6667021-0	1983	Calcium-induced changes in thyroglobulin conformation.	Calcium	0-7	thyroglobulin	Homo sapiens	27-40
6667021-1	1983	Polyethylene glycol solutions (10% w/v) were used to detect the effect of mono- and divalent cations on some properties of thyroglobulin.	Polyethylene Glycols	0-19	thyroglobulin	Homo sapiens	123-136
6667021-2	1983	It is shown that in presence of 10% w/v polyethylene glycol in 0.01 M Tris-HCl, pH 7.5, calcium (less than 0.05 M) modifies the solubility, the sedimentation rate, and the Stokes" radius of thyroglobulin, while monovalent cations up to 0.6 M do not effect any of these properties.	Polyethylene Glycols	40-59	thyroglobulin	Homo sapiens	190-203
6667021-2	1983	It is shown that in presence of 10% w/v polyethylene glycol in 0.01 M Tris-HCl, pH 7.5, calcium (less than 0.05 M) modifies the solubility, the sedimentation rate, and the Stokes" radius of thyroglobulin, while monovalent cations up to 0.6 M do not effect any of these properties.	Calcium	88-95	thyroglobulin	Homo sapiens	190-203
6627204-4	1983	In some patients treated successfully with 131I, the thyroglobulin level remained elevated for several months before falling to within the normal range.	Iodine-131	43-47	thyroglobulin	Homo sapiens	53-66
6627204-10	1983	(2) Thyroglobulin levels correlate with tumor growth in most cases of tumor progression, even when changes in differentiation may have led to a loss of radioiodine uptake by the metastases.	Iodine-131	152-163	thyroglobulin	Homo sapiens	4-17
6641909-0	1983	Iodine-induced changes in thyroglobulin half-sized subunits.	Iodine	0-6	thyroglobulin	Homo sapiens	26-39
6628320-1	1983	Tunicamycin, an inhibitor of glycosylation, was incubated with ovine thyroid cells in culture to determine the role of glycosylation in the subsequent processing of thyroglobulin to form thyroid hormone.	Tunicamycin	0-11	thyroglobulin	Homo sapiens	165-178
6628320-5	1983	A low mol wt fragment of thyroglobulin was found after tunicamycin treatment, indicating increased susceptibility to or contact with proteases.	Tunicamycin	55-66	thyroglobulin	Homo sapiens	25-38
6688257-0	1983	Quantitative in situ hybridization of 3H-labeled complementary deoxyribonucleic acid (cDNA) to the messenger ribonucleic acid of thyroglobulin in human thyroid tissues.	Tritium	38-40	thyroglobulin	Homo sapiens	129-142
6688257-3	1983	Conditions for quantitative in situ hybridization of [3H]DNA complementary to the mRNA of Tgb are described.	Tritium	54-56	thyroglobulin	Homo sapiens	90-93
6349629-1	1983	Reduced and S-alkylated human thyroglobulin (hTgb), normally iodinated, was previously shown by SDS/PAGE to contain a small peptide (Mr 26 000) rich in thyroxine.	Thyroxine	152-161	thyroglobulin	Homo sapiens	30-43
6234970-1	1984	At moderate iodination levels (about 20 iodine atoms/mol) human thyroglobulin yields after reduction and alkylation a hormone (T4)-containing N-terminal peptide of 26K.	Iodine	40-46	thyroglobulin	Homo sapiens	64-77
6640494-0	1983	Synthesis of thyroglobulin in thyroid carcinoma patients after radioiodine therapy.	Iodine-131	63-74	thyroglobulin	Homo sapiens	13-26
6640494-1	1983	Endogenously radioiodinated thyroglobulin (Tg) and the serum concentration of Tg have been measured in patients with metastatic thyroid carcinoma after therapeutic doses of radioiodine.	Iodine-131	173-184	thyroglobulin	Homo sapiens	78-80
6630417-0	1983	Iodine content of serum thyroglobulin in normal individuals and patients with thyroid tumors.	Iodine	0-6	thyroglobulin	Homo sapiens	24-37
6630417-1	1983	We indirectly estimated the iodine content of serum thyroglobulin (TG) in normal individuals and patients with benign and malignant thyroid tumors.	Iodine	28-34	thyroglobulin	Homo sapiens	52-65
6630417-1	1983	We indirectly estimated the iodine content of serum thyroglobulin (TG) in normal individuals and patients with benign and malignant thyroid tumors.	Iodine	28-34	thyroglobulin	Homo sapiens	67-69
6630417-4	1983	The iodine content of the tumor TG was much less than that of normal TG in four of the five patients.	Iodine	4-10	thyroglobulin	Homo sapiens	32-34
6630417-5	1983	In patients with benign and malignant nodules, the iodine content of serum TG was lower than that of normal TG, and it was similar in patients with benign and malignant disease.	Iodine	51-57	thyroglobulin	Homo sapiens	75-77
6630417-6	1983	In normal individuals, serum TG was also poor in iodine, similar to the serum TG from the patients, and in the same position as TG with virtually no iodine.	Iodine	49-55	thyroglobulin	Homo sapiens	29-31
6630417-11	1983	Since the elevated serum TG found in patients with nodules also is poor in iodine, it must come directly from the tumor rather than from destruction of surrounding normal thyroid tissue.	Iodine	75-81	thyroglobulin	Homo sapiens	25-27
6639666-2	1983	After denaturation by glyoxal-DMSO treatment, the RNAs were analyzed on agarose gels, transferred onto nitrocellulose filters and hybridized with a [32P]-labelled thyroglobulin cDNA clone.	Phosphorus-32	149-152	thyroglobulin	Homo sapiens	163-176
6311200-1	1983	Homologous species specificity is demonstrated with bovine and human thyroglobulin in which the two terminal sugars of the B carbohydrate chain, sialic acid and galactose have been removed by enzymatic hydrolysis.	Sugars	109-115	thyroglobulin	Homo sapiens	69-82
6311200-1	1983	Homologous species specificity is demonstrated with bovine and human thyroglobulin in which the two terminal sugars of the B carbohydrate chain, sialic acid and galactose have been removed by enzymatic hydrolysis.	Carbohydrates	125-137	thyroglobulin	Homo sapiens	69-82
6311200-1	1983	Homologous species specificity is demonstrated with bovine and human thyroglobulin in which the two terminal sugars of the B carbohydrate chain, sialic acid and galactose have been removed by enzymatic hydrolysis.	N-Acetylneuraminic Acid	145-156	thyroglobulin	Homo sapiens	69-82
6311200-1	1983	Homologous species specificity is demonstrated with bovine and human thyroglobulin in which the two terminal sugars of the B carbohydrate chain, sialic acid and galactose have been removed by enzymatic hydrolysis.	Galactose	161-170	thyroglobulin	Homo sapiens	69-82
6349629-0	1983	Amino acid sequence around a hormonogenic tyrosine residue in the N-terminal region of human thyroglobulin after in vivo and in vitro iodination.	Tyrosine	42-50	thyroglobulin	Homo sapiens	93-106
6349629-1	1983	Reduced and S-alkylated human thyroglobulin (hTgb), normally iodinated, was previously shown by SDS/PAGE to contain a small peptide (Mr 26 000) rich in thyroxine.	Sodium Dodecyl Sulfate	96-99	thyroglobulin	Homo sapiens	30-43
6680308-3	1983	It was demonstrated that enzymatic removal of some thyroglobulin sialic acids results in increasing its resistance to proteolysis.	Sialic Acids	65-77	thyroglobulin	Homo sapiens	51-64
6680308-4	1983	Apparently, sialic acids are essential for maintaining an optimal thyroglobulin conformation for the action of proteases at hormonal biosynthesis from the reserve form.	Sialic Acids	12-24	thyroglobulin	Homo sapiens	66-79
6411392-10	1983	Mild thyroid hypofunction is common after mantle irradiation for Hodgkin"s disease and raised serum thyroglobulin levels are a sensitive indicator of TSH stimulation of the damaged thyroid gland.	Thyrotropin	150-153	thyroglobulin	Homo sapiens	100-113
6850505-6	1983	Those with TgAb and normal Tg values all had high Tg levels off thyroxine substitution.	Thyroxine	64-73	thyroglobulin	Homo sapiens	11-13
6883731-1	1983	IgG antibody to human thyroglobulin was labelled with 131Iodine (131I) and used to locate deposits of thyroid follicular and papillary tumours with a gamma camera.	Iodine-131	54-63	thyroglobulin	Homo sapiens	22-35
6883731-1	1983	IgG antibody to human thyroglobulin was labelled with 131Iodine (131I) and used to locate deposits of thyroid follicular and papillary tumours with a gamma camera.	Iodine-131	54-58	thyroglobulin	Homo sapiens	22-35
6343118-1	1983	Reduced and S-alkylated thyroglobulin (Tgb) from different species were shown by SDS-PAGE to contain small peptides (from 45-9 kDa) rich in thyroxine.	Sodium Dodecyl Sulfate	81-84	thyroglobulin	Homo sapiens	24-37
6343118-1	1983	Reduced and S-alkylated thyroglobulin (Tgb) from different species were shown by SDS-PAGE to contain small peptides (from 45-9 kDa) rich in thyroxine.	Sodium Dodecyl Sulfate	81-84	thyroglobulin	Homo sapiens	39-42
6343118-1	1983	Reduced and S-alkylated thyroglobulin (Tgb) from different species were shown by SDS-PAGE to contain small peptides (from 45-9 kDa) rich in thyroxine.	Thyroxine	140-149	thyroglobulin	Homo sapiens	24-37
6343118-1	1983	Reduced and S-alkylated thyroglobulin (Tgb) from different species were shown by SDS-PAGE to contain small peptides (from 45-9 kDa) rich in thyroxine.	Thyroxine	140-149	thyroglobulin	Homo sapiens	39-42
6838223-18	1983	At total iodine levels above 14 g.a./mol Tg in enzymatically treated samples there is selective incorporation of iodine into both the low-molecular-weight polypeptides and into thyroid hormone.	Iodine	113-119	thyroglobulin	Homo sapiens	41-43
6838223-1	1983	The distribution of iodine among the polypeptides of human goiter thyroglobulin (Tg) was examined.	Iodine	20-26	thyroglobulin	Homo sapiens	66-79
6838223-1	1983	The distribution of iodine among the polypeptides of human goiter thyroglobulin (Tg) was examined.	Iodine	20-26	thyroglobulin	Homo sapiens	81-83
6867597-2	1983	The previous preparation procedure for isolating the human thyroglobulin currently used in our laboratory, has some inconveniences as regards the low yield and the noxious influence of the ammonium sulfate precipitation upon its molecular integrity.	Ammonium Sulfate	189-205	thyroglobulin	Homo sapiens	59-72
6838223-2	1983	Tg was iodinated in vitro with 131I to levels of 2 to 84 gram atoms (g.a.	Iodine-131	31-35	thyroglobulin	Homo sapiens	0-2
6838223-6	1983	Iodination of these peptides increased sharply in the TPO-treated Tg as the level of total iodine/molecule rose.	Iodine	91-97	thyroglobulin	Homo sapiens	66-68
6838223-7	1983	Radioiodine was incorporated into these same gel regions in the chemically treated Tg, but only after much higher levels of total iodination were reached.	Iodine-131	0-11	thyroglobulin	Homo sapiens	83-85
6838223-15	1983	The addition of free DIT (a known coupling enhancer) to the [131I]Tg/TPO incubation increased both the production of T4 and the amount of iodine in the smaller polypeptides.	3,3'-diindolyl-2,2'-tetrasulfide	21-24	thyroglobulin	Homo sapiens	66-68
6838223-15	1983	The addition of free DIT (a known coupling enhancer) to the [131I]Tg/TPO incubation increased both the production of T4 and the amount of iodine in the smaller polypeptides.	Iodine	138-144	thyroglobulin	Homo sapiens	66-68
6838223-18	1983	At total iodine levels above 14 g.a./mol Tg in enzymatically treated samples there is selective incorporation of iodine into both the low-molecular-weight polypeptides and into thyroid hormone.	Iodine	9-15	thyroglobulin	Homo sapiens	41-43
6867597-5	1983	Thyroglobulin B grade is further submitted to preparative polyacrylamide gel electrophoresis for separating some thyroglobulin isomers as recognized by other groups using the analytical ultracentrifugation procedure.	polyacrylamide	58-72	thyroglobulin	Homo sapiens	0-13
6833229-0	1983	Effect of the complex carbohydrate moiety on the structure of thyroglobulin.	Carbohydrates	22-34	thyroglobulin	Homo sapiens	62-75
6844904-9	1983	TG is TSH-dependent and increases after withdrawal of T3 replacement therapy.	Thyrotropin	6-9	thyroglobulin	Homo sapiens	0-2
6847868-4	1983	On the other hand, a positive correlation was found between serum TSH and Tg levels (rs = 0.455; r = 0.421; P less than 0.01).	Thyrotropin	66-69	thyroglobulin	Homo sapiens	74-76
6353537-2	1983	The method is based on a "sandwich" using purified human thyroglobulin adsorbed to polystyrene microplates, human serum and anti-human IgG antiserum conjugated to alkaline phosphatase.	Polystyrenes	83-94	thyroglobulin	Homo sapiens	57-70
6186883-1	1983	Human iodothyronine-binding auto-antisera were used to define a thyroxyl containing antigenic site on thyroglobulin.	iodothyronine	6-19	thyroglobulin	Homo sapiens	102-115
6186883-1	1983	Human iodothyronine-binding auto-antisera were used to define a thyroxyl containing antigenic site on thyroglobulin.	thyroxyl	64-72	thyroglobulin	Homo sapiens	102-115
6186883-2	1983	The peptide sequences flanking the thyroxyl residue are important antigenic determinants of this region and only one such thyroxyl seems to be exposed on the thyroglobulin molecule.	thyroxyl	122-130	thyroglobulin	Homo sapiens	158-171
6847868-7	1983	Also, a direct correlation was noted between serum TSH and Tg levels.	Thyrotropin	51-54	thyroglobulin	Homo sapiens	59-61
7113586-1	1982	The hormone content of in vitro iodinated thyroglobulin is a constant fraction of the iodine content of the protein under most, but not all, experimental conditions.	Iodine	86-92	thyroglobulin	Homo sapiens	42-55
6187336-0	1982	Restricted antigenicity of thyroxyls in human thyroglobulin.	thyroxyls	27-36	thyroglobulin	Homo sapiens	46-59
7177824-4	1982	The destruction of thyroid residues with Iodine 131 in poor prognosis patients facilitates monitoring by means of Tg assays.	Iodine	41-47	thyroglobulin	Homo sapiens	114-116
6814409-3	1982	A significant correlation (r = 0.670, p less than 0.001) was found between serum thyroglobulin levels and quantitative 131I uptake in the neck and/or metastases in 42 patients in whom this was measured.	Iodine-131	119-123	thyroglobulin	Homo sapiens	81-94
7074544-0	1982	Disappearance rate of endogenously radioiodinated thyroglobulin and thyroxine after radioiodine treatment.	Iodine-131	84-95	thyroglobulin	Homo sapiens	50-63
7074544-1	1982	Endogenously radioiodinated thyroglobulin (tg) and thyroxine (T4), in the circulation following, therapeutic doses of radioiodine were studied in five patients with differentiated thyroid carcinoma.	Iodine-131	118-129	thyroglobulin	Homo sapiens	28-41
7113586-2	1982	In contrast, in vivo iodinated human thyroglobulin may contain as little as 10% or as much as 50% of its total iodine in the T4 molecules.	Iodine	111-117	thyroglobulin	Homo sapiens	37-50
7113586-4	1982	The mechanism of the apparent dissociation between iodination and coupling efficiency (i.e. percentage of total iodine present as iodothyronines) may be dilution of pre-existing high iodinated thyroglobulin stores by non-iodinated prethyroglobulin.	iodothyronines	130-144	thyroglobulin	Homo sapiens	193-206
6896112-0	1982	A prospective study of the differential changes in serum thyroglobulin and its autoantibodies during propylthiouracil or radioiodine therapy of patients with Graves" disease.	Propylthiouracil	101-117	thyroglobulin	Homo sapiens	57-70
6896112-0	1982	A prospective study of the differential changes in serum thyroglobulin and its autoantibodies during propylthiouracil or radioiodine therapy of patients with Graves" disease.	Iodine-131	121-132	thyroglobulin	Homo sapiens	57-70
6896112-4	1982	Serum Tg showed a steady increase during the first weeks after radioiodine treatment, but fell to lower levels after one year.	Iodine-131	63-74	thyroglobulin	Homo sapiens	6-8
6896112-5	1982	PTU caused only minor changes in the serum Tg concentration.	Propylthiouracil	0-3	thyroglobulin	Homo sapiens	43-45
6858557-1	1983	Naturally occurring euthyroid goitres in man and goitres produced in experimental animals by iodine deficiency or goitrogen feeding both have in common a thyroglobulin of low iodine content.	Iodine	93-99	thyroglobulin	Homo sapiens	154-167
6858557-1	1983	Naturally occurring euthyroid goitres in man and goitres produced in experimental animals by iodine deficiency or goitrogen feeding both have in common a thyroglobulin of low iodine content.	Iodine	175-181	thyroglobulin	Homo sapiens	154-167
6858557-11	1983	As an alternative to Marine"s hypothesis of colloid goitre formation we suggest that inhibition of endocytosis, e g by goitrogens of the lithium type, could cause colloid and thyroglobulin accumulation in human iodine deficiency goitre.	Lithium	137-144	thyroglobulin	Homo sapiens	175-188
6858557-11	1983	As an alternative to Marine"s hypothesis of colloid goitre formation we suggest that inhibition of endocytosis, e g by goitrogens of the lithium type, could cause colloid and thyroglobulin accumulation in human iodine deficiency goitre.	Iodine	211-217	thyroglobulin	Homo sapiens	175-188