PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 11136139-7 2001 The 4-hour CST results were significantly different between study groups, with a normal response in 100% of control patients vs 30% of etomidate patients (p = 0.004). Etomidate 135-144 cystatin 12, pseudogene Homo sapiens 11-14 11209968-1 2000 The idea of replacing 17beta-oestradiol (E2) and progesterone (P) in preterm infants is based on the observation that during pregnancy E2 and P plasma concentrations rise in the mother and the fetus by a factor of 100. Progesterone 49-61 cystatin 12, pseudogene Homo sapiens 135-143 11151401-12 2000 This is because of the higher incidence of adverse events among E2/NETA-treated patients, which also results in a higher continuation rate among tibolone-treated patients. tibolone 145-153 cystatin 12, pseudogene Homo sapiens 64-71 10782199-2 2000 The TWA concentrations of the hydrocarbons detected by CST/GC analysis were summed for comparison with the TWA concentration obtained from the direct-reading PID. Hydrocarbons 30-42 cystatin 12, pseudogene Homo sapiens 55-58 10782199-6 2000 Based on the linear regression analyses, the response of the portable PID was highly correlated to the CST/GC results for hydrocarbon mixtures encountered during various painting tasks. Hydrocarbons 122-133 cystatin 12, pseudogene Homo sapiens 103-106 10746893-11 2000 The antioxidant effect also reached a plateau at concentrations of 50 microM of E2 and 1 mM of alpha-tocopherol; gamma-tocopherol and melatonin did not reach a plateau at any dose tested. alpha-Tocopherol 95-111 cystatin 12, pseudogene Homo sapiens 80-88 10769699-0 2000 Effect of E-2-(4"-methoxybenzylidene)-1-benzosuberone on the 7,12-dimethylbenz[alpha]anthracene-induced onco/suppressor gene action in vivo. 7,12-dimethylbenz[alpha]anthracene 61-95 cystatin 12, pseudogene Homo sapiens 10-13 10853242-2 2000 The primary stimulus that comprises this integrative hormonal prostaglandin-leukocytic mechanism is a suppression of local progesterone action with further inhibition of perivascular prostaglandine dehydrogenase and sharp increase of E2 and F2 prostaglandine content in uteroplacentary mechanism bed. Prostaglandins 62-75 cystatin 12, pseudogene Homo sapiens 234-243 10853242-2 2000 The primary stimulus that comprises this integrative hormonal prostaglandin-leukocytic mechanism is a suppression of local progesterone action with further inhibition of perivascular prostaglandine dehydrogenase and sharp increase of E2 and F2 prostaglandine content in uteroplacentary mechanism bed. Progesterone 123-135 cystatin 12, pseudogene Homo sapiens 234-243 10579798-9 2000 Therefore, the ratio of estradiol to dihydrotestosterone concentration (E2/DHT) in prostate increased with age. Estradiol 24-33 cystatin 12, pseudogene Homo sapiens 72-78 10579798-9 2000 Therefore, the ratio of estradiol to dihydrotestosterone concentration (E2/DHT) in prostate increased with age. Dihydrotestosterone 37-56 cystatin 12, pseudogene Homo sapiens 72-78 11479950-5 1999 E2 and MPA in combination with doxorubin showed a synergistic inhibition effect on OVCAR-3 cell growth, which suggested that both of them could reverse the doxorubin resistance of OVCAR-3 cell line. Doxorubicin 156-165 cystatin 12, pseudogene Homo sapiens 0-10 11479950-6 1999 The inhibition effect of Verapamil combined with doxorubin was obviously weaker than that of E2 and MPA. Verapamil 25-34 cystatin 12, pseudogene Homo sapiens 93-103 11479950-7 1999 CONCLUSIONS: E2 and MPA could reverse the doxorubin resistance of OVCAR-3 cell line and their inhibition were more obvious than that of verapamil, which suggested that E2 and MPA may be used clinically for adjuvant chemotherapy. Verapamil 136-145 cystatin 12, pseudogene Homo sapiens 168-178 10510460-4 1999 E-2 displaced [3H]-DPN binding in CHOmu and SH-SY5Y cells with pKi values of 7.82+/-0.11 and 8.43+/-0.13 respectively. Tritium 15-17 cystatin 12, pseudogene Homo sapiens 0-3 10510460-4 1999 E-2 displaced [3H]-DPN binding in CHOmu and SH-SY5Y cells with pKi values of 7.82+/-0.11 and 8.43+/-0.13 respectively. NAD 19-22 cystatin 12, pseudogene Homo sapiens 0-3 10224068-2 1999 The cyclooxygenase-derived endoperoxide, prostaglandin H2, can undergo rearrangement to highly reactive gamma-ketoaldehyde secoprostanoids (levuglandin E2 and D2). endoperoxide 27-39 cystatin 12, pseudogene Homo sapiens 152-161 10319084-4 1999 Moreover, the production of AII is interrelated with the vasodilator substances bradykinin, nitric oxide, and prostaglandins E2 and I2 (prostacyclin). Epoprostenol 136-148 cystatin 12, pseudogene Homo sapiens 125-134 10422913-9 1999 Androstendione correlated positively with both E2 and E1 and testosterone postmenopausally. Androstenedione 0-14 cystatin 12, pseudogene Homo sapiens 47-56 10100178-2 1999 Insulin sensitivity with the use of continuous combined 17-beta estradiol/norethisterone acetate (E2/NETA) preparations has not been examined before in postmenopausal women. Norethindrone Acetate 74-96 cystatin 12, pseudogene Homo sapiens 98-105 10100178-11 1999 Total cholesterol decreased by 12% and 8% in women treated with high dose and low dose E2/NETA (p < 0.02), respectively, and remained unchanged within the P group. Cholesterol 6-17 cystatin 12, pseudogene Homo sapiens 87-94 10100178-14 1999 The effects of E2/NETA on other parameters of carbohydrate and lipid metabolism are neutral or favorable. Carbohydrates 46-58 cystatin 12, pseudogene Homo sapiens 15-22 10224068-2 1999 The cyclooxygenase-derived endoperoxide, prostaglandin H2, can undergo rearrangement to highly reactive gamma-ketoaldehyde secoprostanoids (levuglandin E2 and D2). Prostaglandin H2 41-57 cystatin 12, pseudogene Homo sapiens 152-161 10224068-2 1999 The cyclooxygenase-derived endoperoxide, prostaglandin H2, can undergo rearrangement to highly reactive gamma-ketoaldehyde secoprostanoids (levuglandin E2 and D2). gamma-ketoaldehyde 104-122 cystatin 12, pseudogene Homo sapiens 152-161 10224068-2 1999 The cyclooxygenase-derived endoperoxide, prostaglandin H2, can undergo rearrangement to highly reactive gamma-ketoaldehyde secoprostanoids (levuglandin E2 and D2). secoprostanoids 123-138 cystatin 12, pseudogene Homo sapiens 152-161 10027598-1 1998 Decidualization of human endometrial stromal (ES) cells in vitro is induced by cAMP analogues and ligands that elevate cellular cAMP levels in a manner resembling the gonadotrophins, prostaglandin E2 and relaxin (RLX). Cyclic AMP 79-83 cystatin 12, pseudogene Homo sapiens 197-211 9861326-7 1998 Periodic fluctuations were detected (by cluster analysis) in LH, E2 and P data series established by frequent sample collections in both the control and naltrexone cycles. Naltrexone 153-163 cystatin 12, pseudogene Homo sapiens 65-73 9649469-3 1998 Immunodominant sites on E2p have been localized to the inner of the two lipoyl domains, where the essential cofactor lipoic acid is attached covalently. Thioctic Acid 117-128 cystatin 12, pseudogene Homo sapiens 24-27 9705753-9 1998 E1-2,3-Q and E2-2,3-Q react regioselectively and quantitatively to form 2-OHE1(E2)-1-SR and 2-OHE1(E 2)-4-SR, in which the 1-isomers are always the major products. -ohe1 73-78 cystatin 12, pseudogene Homo sapiens 99-102 9705753-9 1998 E1-2,3-Q and E2-2,3-Q react regioselectively and quantitatively to form 2-OHE1(E2)-1-SR and 2-OHE1(E 2)-4-SR, in which the 1-isomers are always the major products. -ohe1 93-98 cystatin 12, pseudogene Homo sapiens 99-102 9651338-1 1998 Apolipoprotein (apo) E2 is often associated with low levels of low density lipoprotein (LDL) cholesterol and high levels of plasma triglycerides in humans. Cholesterol 93-104 cystatin 12, pseudogene Homo sapiens 21-23 9651338-1 1998 Apolipoprotein (apo) E2 is often associated with low levels of low density lipoprotein (LDL) cholesterol and high levels of plasma triglycerides in humans. Triglycerides 131-144 cystatin 12, pseudogene Homo sapiens 21-23 9383273-12 1997 A pretreatment with dexa, E2, and D3 significantly increased the mitogenic response of HOCs to DHT. Dexamethasone 20-24 cystatin 12, pseudogene Homo sapiens 26-36 9674635-3 1998 In VSMCs, both E2 and DHT had a biphasic effect on [3H]thymidine incorporation into DNA: low concentrations (0.3 nmol/L for E2, 3 nmol/L for DHT) stimulated [3H]thymidine incorporation (+35% and +41%, respectively), whereas high concentrations (30 nmol/L for E2, 300 nmol/L for DHT) inhibited [3H]thymidine incorporation (-40%). Tritium 52-54 cystatin 12, pseudogene Homo sapiens 15-25 9674635-3 1998 In VSMCs, both E2 and DHT had a biphasic effect on [3H]thymidine incorporation into DNA: low concentrations (0.3 nmol/L for E2, 3 nmol/L for DHT) stimulated [3H]thymidine incorporation (+35% and +41%, respectively), whereas high concentrations (30 nmol/L for E2, 300 nmol/L for DHT) inhibited [3H]thymidine incorporation (-40%). Thymidine 55-64 cystatin 12, pseudogene Homo sapiens 15-25 9674635-3 1998 In VSMCs, both E2 and DHT had a biphasic effect on [3H]thymidine incorporation into DNA: low concentrations (0.3 nmol/L for E2, 3 nmol/L for DHT) stimulated [3H]thymidine incorporation (+35% and +41%, respectively), whereas high concentrations (30 nmol/L for E2, 300 nmol/L for DHT) inhibited [3H]thymidine incorporation (-40%). Tritium 158-160 cystatin 12, pseudogene Homo sapiens 15-25 9674635-3 1998 In VSMCs, both E2 and DHT had a biphasic effect on [3H]thymidine incorporation into DNA: low concentrations (0.3 nmol/L for E2, 3 nmol/L for DHT) stimulated [3H]thymidine incorporation (+35% and +41%, respectively), whereas high concentrations (30 nmol/L for E2, 300 nmol/L for DHT) inhibited [3H]thymidine incorporation (-40%). Thymidine 161-170 cystatin 12, pseudogene Homo sapiens 15-25 9674635-3 1998 In VSMCs, both E2 and DHT had a biphasic effect on [3H]thymidine incorporation into DNA: low concentrations (0.3 nmol/L for E2, 3 nmol/L for DHT) stimulated [3H]thymidine incorporation (+35% and +41%, respectively), whereas high concentrations (30 nmol/L for E2, 300 nmol/L for DHT) inhibited [3H]thymidine incorporation (-40%). Dihydrotestosterone 141-144 cystatin 12, pseudogene Homo sapiens 15-25 9674635-3 1998 In VSMCs, both E2 and DHT had a biphasic effect on [3H]thymidine incorporation into DNA: low concentrations (0.3 nmol/L for E2, 3 nmol/L for DHT) stimulated [3H]thymidine incorporation (+35% and +41%, respectively), whereas high concentrations (30 nmol/L for E2, 300 nmol/L for DHT) inhibited [3H]thymidine incorporation (-40%). Tritium 158-160 cystatin 12, pseudogene Homo sapiens 15-25 9674635-3 1998 In VSMCs, both E2 and DHT had a biphasic effect on [3H]thymidine incorporation into DNA: low concentrations (0.3 nmol/L for E2, 3 nmol/L for DHT) stimulated [3H]thymidine incorporation (+35% and +41%, respectively), whereas high concentrations (30 nmol/L for E2, 300 nmol/L for DHT) inhibited [3H]thymidine incorporation (-40%). Thymidine 161-170 cystatin 12, pseudogene Homo sapiens 15-25 9674635-5 1998 In VSMCs, high concentrations of E2 and DHT inhibited platelet-derived growth factor (PDGF)-or insulin-like growth factor (IGF-1)-induced DNA synthesis (-50% to 80%), whereas PDGF- or IGF-1-dependent DNA synthesis in E304 cells was further increased by E2. vsmcs 3-8 cystatin 12, pseudogene Homo sapiens 33-43 9417770-4 1998 While estradiol (E 2 ) and estriol (E 3 ; a relatively weak natural estrogen) readily induced vascular responses [median effective dose (ED 50 ) <10 -9 mol], much higher amounts of xenoestrogens were required. Estradiol 6-15 cystatin 12, pseudogene Homo sapiens 17-20 9383273-12 1997 A pretreatment with dexa, E2, and D3 significantly increased the mitogenic response of HOCs to DHT. hocs 87-91 cystatin 12, pseudogene Homo sapiens 26-36 9383273-12 1997 A pretreatment with dexa, E2, and D3 significantly increased the mitogenic response of HOCs to DHT. Dihydrotestosterone 95-98 cystatin 12, pseudogene Homo sapiens 26-36 9322624-6 1997 Interleukin-1 receptor antagonist inhibited interleukin-1 alpha- and interleukin-1 beta-induced prostaglandin formation, with 50% inhibitory concentration values of 30 ng/ml for prostaglandin E2 and 90 ng/ml for prostaglandin F2 alpha. Prostaglandins 96-109 cystatin 12, pseudogene Homo sapiens 192-201 9374479-6 1997 Treatment of hGHE2t protein by beta-mercaptoethanol, but not by heat and SDS, significantly reduced its reactivity to the antibodies of patient sera, suggesting that intermolecular and/or intramolecular disulfide bonds are important for its ability to recognize its specific antibody and that the E2 protein contains discontinuous antigenic epitope(s). Mercaptoethanol 31-51 cystatin 12, pseudogene Homo sapiens 16-18 9374479-6 1997 Treatment of hGHE2t protein by beta-mercaptoethanol, but not by heat and SDS, significantly reduced its reactivity to the antibodies of patient sera, suggesting that intermolecular and/or intramolecular disulfide bonds are important for its ability to recognize its specific antibody and that the E2 protein contains discontinuous antigenic epitope(s). Disulfides 203-212 cystatin 12, pseudogene Homo sapiens 16-18 9105568-4 1997 In the E2/NETA group, after 12 months hormone replacement therapy (HRT), the HDL2 cholesterol concentration decreased by 17% (P < 0.01) and the HDL3 cholesterol remained unchanged. Cholesterol 82-93 cystatin 12, pseudogene Homo sapiens 7-14 9105568-4 1997 In the E2/NETA group, after 12 months hormone replacement therapy (HRT), the HDL2 cholesterol concentration decreased by 17% (P < 0.01) and the HDL3 cholesterol remained unchanged. Cholesterol 152-163 cystatin 12, pseudogene Homo sapiens 7-14 9105568-7 1997 In the E2/MPA group the HDL2 and HDL3 cholesterol levels were both reduced by 6% (P < 0.05) and the HDL3a, HDL3b and HDL3c concentrations decreased by 14, 12 and 17% during the E2/MPA phase compared with baseline (P < 0.01). Cholesterol 38-49 cystatin 12, pseudogene Homo sapiens 7-13 9618948-4 1997 We observed a low positive correlation, conserving the concentration of thiocyanates in mothers and E2 and Prl. Thiocyanates 72-84 cystatin 12, pseudogene Homo sapiens 100-110 9079642-9 1997 Using site-directed mutagenesis we demonstrate that an arginine at position 304 of the hE2 protein is responsible for the recognition of specific base pairs at this position. Arginine 55-63 cystatin 12, pseudogene Homo sapiens 87-90 9815674-0 1997 Effect of aspirin on prostaglandin E2 and leukotriene B4 production in human colonic mucosa from cancer patients. Aspirin 10-17 cystatin 12, pseudogene Homo sapiens 35-56 7694896-2 1993 Immunodominant sites on E2p have been localized to the inner lipoyl domain, which serves as a covalent attachment site for the essential cofactor, lipoic acid. Thioctic Acid 147-158 cystatin 12, pseudogene Homo sapiens 24-27 9020517-5 1997 The lowest IC50 values were found for VPA (52 +/- 7 and 86 +/- 11 microM for thick and thin fibers, respectively), which in vivo caused the highest rate of exencephaly among the three compounds tested, ( +/- )-4-en-VPA exhibited intermediate values (150 +/- 30 and 300 +/- 40 microM), whereas the highest IC50 values were found for E-2-en-VPA (260 +/- 42 and 430 +/- 40 microM). Valproic Acid 38-41 cystatin 12, pseudogene Homo sapiens 332-335 7626463-8 1995 TDS changed weekly and delivering both E2 and levonorgestrel (L-NG) at daily dosages of 38.4 (+/- 7.5) and 28.8 (+/- 7.2) micrograms/10 cm2 per day respectively, showed ovulation suppression. Levonorgestrel 62-66 cystatin 12, pseudogene Homo sapiens 39-60 10057440-0 1994 E2 and E3 transitions from quadrupole-octupole coupled states in 144Nd. octupole 38-46 cystatin 12, pseudogene Homo sapiens 0-9 8264651-1 1994 Two phorbol ester-inducible elements (beta E2 and beta E3) within the human T-cell receptor beta gene enhancer each contain consensus binding sites for the Ets and core binding factor (CBF) transcription factor families. Phorbol Esters 4-17 cystatin 12, pseudogene Homo sapiens 43-57 8917688-3 1996 Epithelial cells exposed to ROFA for 24 hr secreted substantially increased amounts of the prostaglandin H synthase (PHS) products prostaglandins E2 and F2 alpha. rofa 28-32 cystatin 12, pseudogene Homo sapiens 146-161 8917688-3 1996 Epithelial cells exposed to ROFA for 24 hr secreted substantially increased amounts of the prostaglandin H synthase (PHS) products prostaglandins E2 and F2 alpha. Prostaglandins 91-104 cystatin 12, pseudogene Homo sapiens 146-161 8862941-0 1996 The effect of 5-aminosalicylate and para-aminosalicylate on the synthesis of prostaglandin E2 and leukotriene B4 in isolated colonic mucosal cells. Mesalamine 14-31 cystatin 12, pseudogene Homo sapiens 91-112 8862941-0 1996 The effect of 5-aminosalicylate and para-aminosalicylate on the synthesis of prostaglandin E2 and leukotriene B4 in isolated colonic mucosal cells. para-aminosalicylate 36-56 cystatin 12, pseudogene Homo sapiens 91-112 7706304-8 1995 Competitive inhibition studies carried out with apolipoprotein E (isoforms E2, E3, and E4), transthyretin, vitronectin, and alpha 1-antichymotrypsin indicate that the complex apoJ.A beta 1-40 cannot be dissociated by any of these competitors at physiologic concentrations. beta 1-40 182-191 cystatin 12, pseudogene Homo sapiens 75-89 7755950-2 1995 Platelets were treated with beta E2, alpha E2, P, or ethanol vehicle for 30 min at 37 degrees C. In males, both beta E2 and P at 10(-5) mol/L reduced the AVP-induced rise in [Ca2+]i, to 72 +/- 3% (mean +/- SEM) and 53 +/- 3%, respectively. Ethanol 53-60 cystatin 12, pseudogene Homo sapiens 117-125 8063615-1 1994 An in vitro assay system for predicting the estradiol (E2) sensitivity of clinical cancer cells was applied to 54 patients with breast carcinoma to compare the responses to E2 and tamoxifen (TAM) with the estrogen receptor (ER) status. Tamoxifen 191-194 cystatin 12, pseudogene Homo sapiens 173-189 8180677-7 1994 Compared to control conditions, the basal serum estrogen (estrone and E2) and progesterone (P4) concentrations markedly increased (p < 0.001) following oral E2 or E2/P4 treatments. Progesterone 78-90 cystatin 12, pseudogene Homo sapiens 166-171 7694896-3 1993 However, it is not clear whether the presence of lipoic acid is necessary for autoimmune recognition of human E2p. Thioctic Acid 49-60 cystatin 12, pseudogene Homo sapiens 110-113 8328127-1 1993 Prostaglandin E-2 (PGE-2) is an oxytocic agent in suppository form with vasodilatory effects similar to prostaglandin E-1 (PGE-1). Dinoprostone 19-24 cystatin 12, pseudogene Homo sapiens 14-17 8262004-4 1993 The current understanding is shaped by the thesis that the concerted central actions of E2 and P are mediated by a host of regulatory peptides produced locally in the hypothalamus, and steroids, in general, augment the production and release of both inhibitory and excitatory peptides in a timely fashion to facilitate the preovulatory LHRH discharge. Steroids 185-193 cystatin 12, pseudogene Homo sapiens 88-96 1479572-4 1992 This priming effect of 1,25-(OH)2D3 was augmented by the addition of E2 and Te at physiologic concentrations, but not by that of P. E2, P and Te at physiologic concentrations enhanced IL-1 beta production by HL-60 cells that were pretreated with 1,25(OH)2D3 and stimulated by LPS. Calcitriol 23-35 cystatin 12, pseudogene Homo sapiens 69-78 8424775-1 1993 The dihydrolipoamide acetyltransferase subunit (E2p) of mammalian pyruvate dehydrogenase complex has two highly conserved lipoyl domains each modified with a lipoyl cofactor bound in amide linkage to a specific lysine residue. Amides 15-20 cystatin 12, pseudogene Homo sapiens 48-51 8424775-1 1993 The dihydrolipoamide acetyltransferase subunit (E2p) of mammalian pyruvate dehydrogenase complex has two highly conserved lipoyl domains each modified with a lipoyl cofactor bound in amide linkage to a specific lysine residue. Lysine 211-217 cystatin 12, pseudogene Homo sapiens 48-51 8435211-3 1993 Here we report on the effect of E2 and tamoxifen (TAM) on IGF-II mRNA and protein expression in the ER+T61 human breast cancer xenograft. Tamoxifen 50-53 cystatin 12, pseudogene Homo sapiens 32-48 8468347-3 1993 By indirect immunofluorescence, E2 and E1 were localized to the Golgi region of all three cell types, and their distribution was disrupted by treatment with BFA or nocodazole. Nocodazole 164-174 cystatin 12, pseudogene Homo sapiens 32-41 1542261-8 1992 Thus, the heterozygote apo E-3/E-2 pattern may be related to the accumulation of beta-VLDL in persons with a very high apo B production rate. beta-vldl 81-90 cystatin 12, pseudogene Homo sapiens 31-34 1326711-0 1992 New clues into the etiology of osteoporosis: the effects of prostaglandins (E2 and F2 alpha) on bone. Prostaglandins 60-74 cystatin 12, pseudogene Homo sapiens 76-91 1326711-2 1992 Prostaglandins (E2 and F2 alpha) at precise concentrations, have been observed to be involved in bone formation. Prostaglandins 0-14 cystatin 12, pseudogene Homo sapiens 16-31 1326711-5 1992 The association between these hormones and prostaglandins (E2 and F2 alpha) explains the physiological mechanism whereby estradiol can be effective for the treatment of osteoporosis. Prostaglandins 43-57 cystatin 12, pseudogene Homo sapiens 59-74 1326711-5 1992 The association between these hormones and prostaglandins (E2 and F2 alpha) explains the physiological mechanism whereby estradiol can be effective for the treatment of osteoporosis. Estradiol 121-130 cystatin 12, pseudogene Homo sapiens 59-74 1326711-7 1992 Mechanisms related to this interaction between various hormones and the effect of prostaglandins (E2 and F2 alpha) on bone formation are discussed. Prostaglandins 82-96 cystatin 12, pseudogene Homo sapiens 98-113 1316682-3 1992 The ionophore carboxyl cyanide m-chlorophenyl-hydrazone was used to show that the E2/NS1 glycoprotein resided in the endoplasmic reticulum. carboxyl cyanide m-chlorophenyl-hydrazone 14-55 cystatin 12, pseudogene Homo sapiens 82-101 1663365-1 1991 The two long-chain alkylamines RO 31-4493 and RO 31-4639 inhibit in a concentration-dependent manner the zymosan-induced release of arachidonic acid, the conversion of arachidonic acid into thromboxane, prostaglandin E2 and D2 and the uptake and incorporation of exogenously added arachidonate into membrane lipids of liver macrophages. alkylamines 19-30 cystatin 12, pseudogene Homo sapiens 217-226 1735482-9 1992 (2) Endometrial total E2 and P receptor levels increased in all women 2.9 to 19.2-fold after tamoxifen. Tamoxifen 93-102 cystatin 12, pseudogene Homo sapiens 22-39 1730809-8 1992 Intraluteal application of PGF2 alpha stimulated OXT, E2, and P release. Dinoprost 27-31 cystatin 12, pseudogene Homo sapiens 54-71 1343873-1 1992 E-2-en-valproate is a major metabolite present in the blood of humans treated with valproate. Valproic Acid 7-16 cystatin 12, pseudogene Homo sapiens 0-3 1663365-1 1991 The two long-chain alkylamines RO 31-4493 and RO 31-4639 inhibit in a concentration-dependent manner the zymosan-induced release of arachidonic acid, the conversion of arachidonic acid into thromboxane, prostaglandin E2 and D2 and the uptake and incorporation of exogenously added arachidonate into membrane lipids of liver macrophages. Zymosan 105-112 cystatin 12, pseudogene Homo sapiens 217-226 1663365-1 1991 The two long-chain alkylamines RO 31-4493 and RO 31-4639 inhibit in a concentration-dependent manner the zymosan-induced release of arachidonic acid, the conversion of arachidonic acid into thromboxane, prostaglandin E2 and D2 and the uptake and incorporation of exogenously added arachidonate into membrane lipids of liver macrophages. Arachidonic Acid 132-148 cystatin 12, pseudogene Homo sapiens 217-226 1653615-6 1991 The results suggest, that in the process of enzyme operation vanadate interacts with the unliganded E form of Ca(2+)-ATPase, occupying probably an intermediate position between the E2 and E1 forms, with the formation of an E2 Van complex, that imposes the inhibition on the Ca(2+)-ATPase activity. Vanadates 61-69 cystatin 12, pseudogene Homo sapiens 181-190 1936317-13 1991 Hence, administration of exogenous E2 and P appears to be a viable simpler alternative to the combined administration of GnRH-a and exogenous E2 and P, which avoids the side effects and the cost of GnRH-a. gnrh-a 198-204 cystatin 12, pseudogene Homo sapiens 35-43 1936317-13 1991 Hence, administration of exogenous E2 and P appears to be a viable simpler alternative to the combined administration of GnRH-a and exogenous E2 and P, which avoids the side effects and the cost of GnRH-a. gnrh-a 198-204 cystatin 12, pseudogene Homo sapiens 142-150 1660487-3 1991 An enhanced production of prostaglandin E2 and thromboxane B2 was detected in monocytes from HIV-positive drug users whether or not they had been previously stimulated with zymosan. Zymosan 173-180 cystatin 12, pseudogene Homo sapiens 40-61 2086575-9 1990 The authors postulate that the hyperestrogenism in this patient was due to increased aromatization of the precursor substrates, testosterone in the testes, and androstenedione in the adrenals to E2 and E1 in the testes and adrenals, respectively. Androstenedione 160-175 cystatin 12, pseudogene Homo sapiens 195-204 1935402-2 1991 The results showed: (1) the serum E2, E3, P, E2/P and Es/P values did not differ significantly between the two groups; (2) the amniotic fluid E2 and E3 concentrations were significantly higher for women in active labor and more evident in those with normal uterine activity, but the progesterone concentration did not vary significantly among the three groups. Progesterone 283-295 cystatin 12, pseudogene Homo sapiens 142-151 1902845-14 1991 LH release in response to exogenous GnRH revealed marked initial responses which did not decrease until day 20, but remained suppressed (8% of basal) after withdrawal of E2 and P. Luteinizing Hormone 0-2 cystatin 12, pseudogene Homo sapiens 170-178 1921737-3 1991 The results show that both E2 and Org OD 14 reduce bone resorption, as indicated by the decreases in the urinary hydroxyproline/creatinine and calcium/creatinine ratios in 2-h fasting urine. Hydroxyproline 113-127 cystatin 12, pseudogene Homo sapiens 27-43 1921737-3 1991 The results show that both E2 and Org OD 14 reduce bone resorption, as indicated by the decreases in the urinary hydroxyproline/creatinine and calcium/creatinine ratios in 2-h fasting urine. Creatinine 128-138 cystatin 12, pseudogene Homo sapiens 27-43 1921737-3 1991 The results show that both E2 and Org OD 14 reduce bone resorption, as indicated by the decreases in the urinary hydroxyproline/creatinine and calcium/creatinine ratios in 2-h fasting urine. Calcium 143-150 cystatin 12, pseudogene Homo sapiens 27-43 1921737-3 1991 The results show that both E2 and Org OD 14 reduce bone resorption, as indicated by the decreases in the urinary hydroxyproline/creatinine and calcium/creatinine ratios in 2-h fasting urine. Creatinine 151-161 cystatin 12, pseudogene Homo sapiens 27-43 1863925-2 1991 Inhibition of the ubiquitous enzyme cyclooxygenase by the nonsteroidal anti-inflammatory drugs including the salicylates prevents the production of endoperoxides, which are pro-inflammatory, and prostaglandins E2 and I2, which sensitize peripheral pain receptors. Salicylates 109-120 cystatin 12, pseudogene Homo sapiens 210-219 2231758-2 1990 We now report that both E2 and tamoxifen (TMX) significantly decreased the fluidity of MCF7 and MDA-MB-436 cellular membranes. Tamoxifen 42-45 cystatin 12, pseudogene Homo sapiens 24-40 1719019-4 1991 In the presence of E2 and P, a 10- to 15-fold increase in IGFBP-2 was detected in the conditioned medium beginning after about 7 days in culture, when cells decidualized and steroid-mediated prolactin secretion began. Steroids 174-181 cystatin 12, pseudogene Homo sapiens 19-27 1706350-9 1991 In the presence of E2 and progesterone, there was an enhancement in the amount of IGFBP-3 and a marked enhancement of IGFBP-2 in the conditioned media, suggesting sex steroid-dependence of IGFBP-2 and, to a lesser extent, IGFBP-3 protein synthesis. Steroids 167-174 cystatin 12, pseudogene Homo sapiens 19-38 2281118-1 1990 Prostaglandins of the E series, primarily E2 and E1, have the greatest activity in bone. Prostaglandins 0-14 cystatin 12, pseudogene Homo sapiens 42-51 2089394-0 1990 New N-substituted derivatives of E-2"- and E-3"-hydroxystilbazoles-(4) of potential antimicrobial activity. Nitrogen 0-1 cystatin 12, pseudogene Homo sapiens 33-36 2288648-2 1990 E2 and P at physiologic concentrations enhanced IL-1 beta and TNF production by monocytes from donors with lower control levels (without steroids added) of IL-1 beta and TNF. Steroids 137-145 cystatin 12, pseudogene Homo sapiens 0-8 2142871-2 1990 Although the stimulatory action of classical estrogens (E2 and estrone) is well known, we have found a potent mitogenic effect of the adrenal estrogen androst-5-ene-3 beta,17 beta-diol (delta 5-diol) at concentrations within the range of those found in the serum of adult women, thus suggesting that delta 5-diol might be the most important estrogen in women. Dehydroepiandrosterone 151-164 cystatin 12, pseudogene Homo sapiens 56-70 2163890-1 1990 A conformational transition between E2 and E1 forms of Na, K-ATPase induced by different nucleotides has been studied under steady state conditions using the enzyme labelled with 5-iodoacetamidofluorescein. 5-iodoacetamidofluorescein 179-205 cystatin 12, pseudogene Homo sapiens 36-67 2163366-3 1990 Zymosan stimulation also caused the release of very small quantities of prostaglandins E2 and F2 alpha, and thromboxane B2. Zymosan 0-7 cystatin 12, pseudogene Homo sapiens 87-102 2187198-2 1990 The major antigens recognized by the antibodies are the E2 components of the 2-oxo acid dehydrogenase complexes, all of which possess covalently attached lipoic acid cofactors. Thioctic Acid 154-165 cystatin 12, pseudogene Homo sapiens 56-58 2112478-3 1990 With or without hyperlipidaemia, the apo E-2/2 phenotype was associated with increased bile acid formation (mean increase compared with 32 normolipidaemic controls, 43%; P less than 0.025). Bile Acids and Salts 87-96 cystatin 12, pseudogene Homo sapiens 41-44 1963697-7 1990 Moreover, they release prostaglandin F2 alpha and E2 from human endometrium or early pregnancy decidua and reduce the metabolism of these eicosanoids. Eicosanoids 138-149 cystatin 12, pseudogene Homo sapiens 37-52 2313199-4 1990 Using preformed plates, pH 5.0-6.0 (LKB, Bromma) after rehydration with 6 M urea and dextran T-10, the IPG focusing pattern of the common isoforms (E2, E3, E4) was found to be equivalent to conventional IEF with the added resolution of the E4 disialo form. dextran t-10 85-97 cystatin 12, pseudogene Homo sapiens 148-159 34247005-3 2021 The degradation rate constants were determined to be 0.20, 0.22 and 0.15 min-1 for BPA, E2 and EE2, respectively. bisphenol A 83-86 cystatin 12, pseudogene Homo sapiens 88-98 2398626-3 1990 The frequency of apo E-4 was higher and that of E-2 was lower in the CCU group than in the control group. cis,cis-Muconic acid 69-72 cystatin 12, pseudogene Homo sapiens 48-51 35489259-5 2022 Hydrophobic interactions were dominant in the non-covalent interactions between (E)-2-octenal/(Z)-2-penten-1-ol and pea protein, whereas hydrogen bonding was dominant in the non-covalent interactions between hexanal and pea protein. cis-2-Penten-1-ol 94-111 cystatin 12, pseudogene Homo sapiens 80-85 34082140-13 2021 In summary, E2 and TNFalpha engaged in an ERalpha-dependent positive crosstalk in lung adenocarcinoma cells, consequently increasing NFkappaB activation, cisplatin tolerance and cell migration and worsening prognosis. Cisplatin 154-163 cystatin 12, pseudogene Homo sapiens 12-27 34461224-10 2021 Simvastatin also inhibited E2 downstream signaling, including ERK and AKT pathways, E2/ER transcriptional activity and E2-responsive genes. Simvastatin 0-11 cystatin 12, pseudogene Homo sapiens 84-89 34461224-10 2021 Simvastatin also inhibited E2 downstream signaling, including ERK and AKT pathways, E2/ER transcriptional activity and E2-responsive genes. Estradiol 27-29 cystatin 12, pseudogene Homo sapiens 84-89 34461224-15 2021 Thus, our data suggest that simvastatin modulates several E2/ER signaling targets with potential implications in leiomyoma therapy and beyond. Simvastatin 28-39 cystatin 12, pseudogene Homo sapiens 58-63 34679678-3 2021 CST/Met (-) depleted reduced and oxidized glutathione in hepatocyte-derived cells, increased prostaglandin-endoperoxide synthase 2 expression, and promoted reactive oxygen species accumulation and lipid peroxidation, as well as necrotic cell death. Glutathione 42-53 cystatin 12, pseudogene Homo sapiens 0-3 34679678-3 2021 CST/Met (-) depleted reduced and oxidized glutathione in hepatocyte-derived cells, increased prostaglandin-endoperoxide synthase 2 expression, and promoted reactive oxygen species accumulation and lipid peroxidation, as well as necrotic cell death. Oxygen 165-171 cystatin 12, pseudogene Homo sapiens 0-3 35489259-5 2022 Hydrophobic interactions were dominant in the non-covalent interactions between (E)-2-octenal/(Z)-2-penten-1-ol and pea protein, whereas hydrogen bonding was dominant in the non-covalent interactions between hexanal and pea protein. Hydrogen 137-145 cystatin 12, pseudogene Homo sapiens 80-85 35149470-5 2022 The aroma recombination and omission experiment further revealed that compounds such as (E)-2-decenal, linalool, 2-furanmethanol, 2-pentylfuran, (E,E)-2,4-heptadienal, nonanal, (E)-2-nonenal, and 1-octen-3-one were the major reason for the odor difference between human milk and infant formula. nonanal 168-175 cystatin 12, pseudogene Homo sapiens 88-93 35149470-5 2022 The aroma recombination and omission experiment further revealed that compounds such as (E)-2-decenal, linalool, 2-furanmethanol, 2-pentylfuran, (E,E)-2,4-heptadienal, nonanal, (E)-2-nonenal, and 1-octen-3-one were the major reason for the odor difference between human milk and infant formula. 1-octen-3-one 196-209 cystatin 12, pseudogene Homo sapiens 88-93 34985191-6 2022 RESULTS: CST stimulated glycogen accumulation in fed and fasted liver and in primary hepatocytes. Glycogen 24-32 cystatin 12, pseudogene Homo sapiens 9-12 35596169-9 2022 Additionally, multivariable analysis in 165 patients whose serum E2 and 25OHD levels were measured showed that both low E2 levels (< 10 pg/mL) and lower 25OHD levels were independently associated with osteoporosis. Estradiol 120-122 cystatin 12, pseudogene Homo sapiens 65-77 35596169-9 2022 Additionally, multivariable analysis in 165 patients whose serum E2 and 25OHD levels were measured showed that both low E2 levels (< 10 pg/mL) and lower 25OHD levels were independently associated with osteoporosis. 25ohd 153-158 cystatin 12, pseudogene Homo sapiens 65-77 34985191-7 2022 CST reduced plasma NE and EPI levels. Epinephrine 26-29 cystatin 12, pseudogene Homo sapiens 0-3 34985191-8 2022 CST also directly stimulated glycogenesis and inhibited NE and EPI-induced glycogenolysis in hepatocytes. Epinephrine 63-66 cystatin 12, pseudogene Homo sapiens 0-3 2719600-3 1989 Whereas the lower cholesterol levels in carriers of the epsilon-2 allele can, at least in part, be attributed to the grossly deficient binding of apo E-2 to the apo B,E receptor, apo E-3 and E-4 bind to the same degree. Cholesterol 18-29 cystatin 12, pseudogene Homo sapiens 150-153 35074437-7 2022 Of considerable recent interest is how E2 and E3 might switch their functional partnerships via UBE2O, which suggests an emerging significance on how UBE2O might influence E2-E3 pairing. Estradiol 172-174 cystatin 12, pseudogene Homo sapiens 39-48 35074437-7 2022 Of considerable recent interest is how E2 and E3 might switch their functional partnerships via UBE2O, which suggests an emerging significance on how UBE2O might influence E2-E3 pairing. e3 175-177 cystatin 12, pseudogene Homo sapiens 39-48 35213517-2 2022 METHODS: REPLENISH evaluated oral estradiol/progesterone (E2/P4) for the treatment of moderate to severe vasomotor symptoms (VMS) in postmenopausal women with a uterus. Estradiol 34-43 cystatin 12, pseudogene Homo sapiens 58-63 35213517-2 2022 METHODS: REPLENISH evaluated oral estradiol/progesterone (E2/P4) for the treatment of moderate to severe vasomotor symptoms (VMS) in postmenopausal women with a uterus. Progesterone 44-56 cystatin 12, pseudogene Homo sapiens 58-63 2507743-1 1989 Prostaglandin E2 and prostacyclin (prostaglandin I2) produce hyperalgesia in animals and humans. Epoprostenol 35-51 cystatin 12, pseudogene Homo sapiens 14-33 35401926-7 2022 Compared with H2O2-stimulated KGN cells, COS significantly increased the levels of E2 and P4 and decreased SA-beta-gal protein expression. Hydrogen Peroxide 14-18 cystatin 12, pseudogene Homo sapiens 83-92 35401926-7 2022 Compared with H2O2-stimulated KGN cells, COS significantly increased the levels of E2 and P4 and decreased SA-beta-gal protein expression. carbonyl sulfide 41-44 cystatin 12, pseudogene Homo sapiens 83-92 35356686-1 2022 This investigation is focused on the synthesis of two halo-functionalized crystalline Schiff base (imine) compounds: (E)-2-methoxy-6-(((3-(trifluoromethyl)phenyl)imino)methyl)phenol (MFIP) and (E)-1-(((2-fluorophenyl)imino)methyl)naphthalen-2-ol (FPIN) by the condensation reaction of substituted benzaldehydes and substituted aniline. Schiff Bases 86-97 cystatin 12, pseudogene Homo sapiens 117-122 35356686-1 2022 This investigation is focused on the synthesis of two halo-functionalized crystalline Schiff base (imine) compounds: (E)-2-methoxy-6-(((3-(trifluoromethyl)phenyl)imino)methyl)phenol (MFIP) and (E)-1-(((2-fluorophenyl)imino)methyl)naphthalen-2-ol (FPIN) by the condensation reaction of substituted benzaldehydes and substituted aniline. Imines 99-104 cystatin 12, pseudogene Homo sapiens 117-122 35356686-1 2022 This investigation is focused on the synthesis of two halo-functionalized crystalline Schiff base (imine) compounds: (E)-2-methoxy-6-(((3-(trifluoromethyl)phenyl)imino)methyl)phenol (MFIP) and (E)-1-(((2-fluorophenyl)imino)methyl)naphthalen-2-ol (FPIN) by the condensation reaction of substituted benzaldehydes and substituted aniline. mfip 183-187 cystatin 12, pseudogene Homo sapiens 117-122 35356686-1 2022 This investigation is focused on the synthesis of two halo-functionalized crystalline Schiff base (imine) compounds: (E)-2-methoxy-6-(((3-(trifluoromethyl)phenyl)imino)methyl)phenol (MFIP) and (E)-1-(((2-fluorophenyl)imino)methyl)naphthalen-2-ol (FPIN) by the condensation reaction of substituted benzaldehydes and substituted aniline. fpin 247-251 cystatin 12, pseudogene Homo sapiens 117-122 35356686-1 2022 This investigation is focused on the synthesis of two halo-functionalized crystalline Schiff base (imine) compounds: (E)-2-methoxy-6-(((3-(trifluoromethyl)phenyl)imino)methyl)phenol (MFIP) and (E)-1-(((2-fluorophenyl)imino)methyl)naphthalen-2-ol (FPIN) by the condensation reaction of substituted benzaldehydes and substituted aniline. Benzaldehydes 297-310 cystatin 12, pseudogene Homo sapiens 117-122 35356686-1 2022 This investigation is focused on the synthesis of two halo-functionalized crystalline Schiff base (imine) compounds: (E)-2-methoxy-6-(((3-(trifluoromethyl)phenyl)imino)methyl)phenol (MFIP) and (E)-1-(((2-fluorophenyl)imino)methyl)naphthalen-2-ol (FPIN) by the condensation reaction of substituted benzaldehydes and substituted aniline. aniline 327-334 cystatin 12, pseudogene Homo sapiens 117-122 34994841-7 2022 Delaying therapy by >= 7 days resulted in increased CST in 47.5%, 58.5%, and 58.9% of nvAMD, DME, and RVO cases, respectively, with a significant correlation between the length of treatment delay and the increase in CST (Spearman"s rho: 0.196; p < 0.001). dimethylethylsilylimidazole 93-96 cystatin 12, pseudogene Homo sapiens 52-55 2542604-3 1989 High-pressure liquid chromatography analysis showed that the radioactivity released from [3H]arachidonate-labeled transformed cells was contained in free arachidonate and in the cyclooxygenase products prostaglandin E2 and prostaglandin F2 alpha; no lipoxygenase products were identified. 3h]arachidonate 90-105 cystatin 12, pseudogene Homo sapiens 216-262 2542604-3 1989 High-pressure liquid chromatography analysis showed that the radioactivity released from [3H]arachidonate-labeled transformed cells was contained in free arachidonate and in the cyclooxygenase products prostaglandin E2 and prostaglandin F2 alpha; no lipoxygenase products were identified. Arachidonic Acid 93-105 cystatin 12, pseudogene Homo sapiens 216-262 2547112-10 1989 In additional experiments the number of normal and abnormal dividing HeLa cells were greatly reduced when simultaneously exposed to E2 and 2-/4-hydroxylase-inhibitor alpha-naphthoflavone. alpha-naphthoflavone 166-186 cystatin 12, pseudogene Homo sapiens 132-140 3655744-15 1987 Between the E2 and E1 genes, there is a stretch of seven amino acids, five of which are arginines, which may serve as cleavage sites for a trypsin-like protease. Arginine 88-97 cystatin 12, pseudogene Homo sapiens 12-21 2538787-5 1989 Progesterone increased significantly above baseline in the E2 and progesterone group (P less than .01), but did not change in the conjugated estrogens and medroxyprogesterone acetate users. Progesterone 0-12 cystatin 12, pseudogene Homo sapiens 59-84 2537176-4 1989 We found that FSH, forskolin, and cAMP all stimulated secretion of E2 and P in a dose-dependent manner in both developmental groups. Colforsin 19-28 cystatin 12, pseudogene Homo sapiens 67-75 2537176-4 1989 We found that FSH, forskolin, and cAMP all stimulated secretion of E2 and P in a dose-dependent manner in both developmental groups. Cyclic AMP 34-38 cystatin 12, pseudogene Homo sapiens 67-75 2537352-0 1989 Eicosanoids in skin of patients with atopic dermatitis: prostaglandin E2 and leukotriene B4 are present in biologically active concentrations. Eicosanoids 0-11 cystatin 12, pseudogene Homo sapiens 70-91 2835101-2 1988 The present work compares the effects of several ligands (phosphatase substrates, MgCl2, RbCl and inorganic phosphate) and temperature on the phosphatase activity and the E2(Rb) occluded conformation of Na+/K+-ATPase. Phosphates 98-117 cystatin 12, pseudogene Homo sapiens 171-177 2835101-4 1988 At 20 degrees C, in the presence of 1 mM RbCl and no Mg2+, acetyl phosphate did not affect E2(Rb); with 3 mM MgCl2, acetyl phosphate stimulated a release of Rb from E2(Rb) both in the presence and absence of RbCl in the incubation mixture. acetyl phosphate 116-132 cystatin 12, pseudogene Homo sapiens 165-171 2832160-0 1988 Pertussis toxin abolishes the inhibitory effects of prostaglandins E1, E2, I2 and F2 alpha on hormone-induced cAMP accumulation in cultured hepatocytes. Cyclic AMP 110-114 cystatin 12, pseudogene Homo sapiens 71-90 3282729-4 1988 Captopril therapy was associated with an increase in plasma renin activity, a decrease in plasma aldosterone and an increase in the urinary excretion of prostaglandin E2 and kallikrein, independent of changes in urine output. Captopril 0-9 cystatin 12, pseudogene Homo sapiens 167-184 3181488-2 1988 Estrogenic and antiestrogenic effects were evaluated in vitro by measuring changes in prostaglandin (PG) output provoked by estradiol (E2), CC, and mixtures of E2 and CC; progestagenic effects were tested with E2 17 beta-dehydrogenase activity and glycogen accumulation as end points. Prostaglandins 86-99 cystatin 12, pseudogene Homo sapiens 160-169 3181488-2 1988 Estrogenic and antiestrogenic effects were evaluated in vitro by measuring changes in prostaglandin (PG) output provoked by estradiol (E2), CC, and mixtures of E2 and CC; progestagenic effects were tested with E2 17 beta-dehydrogenase activity and glycogen accumulation as end points. Prostaglandins 101-103 cystatin 12, pseudogene Homo sapiens 160-169 3051134-0 1988 Effects of estradiol-17 beta and progesterone on the synthesis of prostaglandin F2 alpha, prostaglandin E2 and prostaglandin I2 by fibroblasts from human endometrium in vitro. Estradiol 11-28 cystatin 12, pseudogene Homo sapiens 104-127 3051134-0 1988 Effects of estradiol-17 beta and progesterone on the synthesis of prostaglandin F2 alpha, prostaglandin E2 and prostaglandin I2 by fibroblasts from human endometrium in vitro. Progesterone 33-45 cystatin 12, pseudogene Homo sapiens 104-127 2898291-3 1988 Prostaglandins E2 and I2 cause hyperalgesia to bradykinin and histamine, and they increase oedema formation. Histamine 62-71 cystatin 12, pseudogene Homo sapiens 15-24 3120517-2 1987 Lipoxygenase and cyclooxygenase-derived substrates possessing an w-6 hydroxyl moiety (15-HETE, 13-HODD and HHT) were metabolized to corresponding keto derivatives at a rate comparable to that for prostaglandins E2 and F2 alpha. Tungsten 65-66 cystatin 12, pseudogene Homo sapiens 211-226 3120517-2 1987 Lipoxygenase and cyclooxygenase-derived substrates possessing an w-6 hydroxyl moiety (15-HETE, 13-HODD and HHT) were metabolized to corresponding keto derivatives at a rate comparable to that for prostaglandins E2 and F2 alpha. 6 hydroxyl 67-77 cystatin 12, pseudogene Homo sapiens 211-226 3120517-2 1987 Lipoxygenase and cyclooxygenase-derived substrates possessing an w-6 hydroxyl moiety (15-HETE, 13-HODD and HHT) were metabolized to corresponding keto derivatives at a rate comparable to that for prostaglandins E2 and F2 alpha. 15-hydroxy-5,8,11,13-eicosatetraenoic acid 86-93 cystatin 12, pseudogene Homo sapiens 211-226 3120517-2 1987 Lipoxygenase and cyclooxygenase-derived substrates possessing an w-6 hydroxyl moiety (15-HETE, 13-HODD and HHT) were metabolized to corresponding keto derivatives at a rate comparable to that for prostaglandins E2 and F2 alpha. Homoharringtonine 107-110 cystatin 12, pseudogene Homo sapiens 211-226 3104011-3 1987 In epithelial cell cultures, the increases in PGF2 alpha output obtained with mixtures of E2 and AA were about 2.5-fold greater than the sum of the increases elicited by E2 or AA alone. Dinoprost 46-50 cystatin 12, pseudogene Homo sapiens 90-99 3029159-7 1987 The increases with E2 and T were reduced significantly by tamoxifen and cyproterone acetate, respectively, suggesting receptor mediation of the steroid effects. Tamoxifen 58-67 cystatin 12, pseudogene Homo sapiens 19-27 3029159-7 1987 The increases with E2 and T were reduced significantly by tamoxifen and cyproterone acetate, respectively, suggesting receptor mediation of the steroid effects. Cyproterone Acetate 72-91 cystatin 12, pseudogene Homo sapiens 19-27 3029159-7 1987 The increases with E2 and T were reduced significantly by tamoxifen and cyproterone acetate, respectively, suggesting receptor mediation of the steroid effects. Steroids 144-151 cystatin 12, pseudogene Homo sapiens 19-27 3109442-0 1987 [Synthesis of (8Z,11Z,14Z)-eicosatrien-5-ynoic (5,6-dehydroarachidonic) acid and its transformation into [5,6-3H]arachidonic acid and [5,6-3H]prostaglandins E2 and F2 alpha]. (8z,11z,14z)-eicosatrien-5-ynoic (5,6-dehydroarachidonic) acid 14-76 cystatin 12, pseudogene Homo sapiens 157-172 3017804-0 1986 Effects of topical 5-aminosalicylic acid and prednisolone on prostaglandin E2 and leukotriene B4 levels determined by equilibrium in vivo dialysis of rectum in relapsing ulcerative colitis. Mesalamine 19-40 cystatin 12, pseudogene Homo sapiens 75-96 3121931-8 1987 When mixtures of E2 and AA were added to the cultures of epithelial cells the increase in PGF2 alpha output was 2.5-fold greater than the sum of the increases elicited by E2 or AA alone. Dinoprost 90-94 cystatin 12, pseudogene Homo sapiens 17-26 3017804-0 1986 Effects of topical 5-aminosalicylic acid and prednisolone on prostaglandin E2 and leukotriene B4 levels determined by equilibrium in vivo dialysis of rectum in relapsing ulcerative colitis. Prednisolone 45-57 cystatin 12, pseudogene Homo sapiens 75-96 3017804-5 1986 Luminal concentrations of prostaglandin E2 and leukotriene B4 were positively correlated to disease activity and significantly decreased among the prednisolone-treated patients. Prednisolone 147-159 cystatin 12, pseudogene Homo sapiens 40-61 3512896-4 1986 Prostaglandin E2 and kallikrein were shown to be involved in the formation of the second- and third-type renal response to excessive salt. Salts 133-137 cystatin 12, pseudogene Homo sapiens 14-31 3758383-9 1986 The steroid-impregnated polysiloxane vaginal ring and cylinder system provided continuous and sustained hormone release, morphologically and endocrinologically normal endometrium, serum levels of E2 and P within the normal range for the entire menstrual cycle, and a convenient and physiologic therapeutic alternative to oral, vaginal, or intramuscular steroid replacement. Siloxanes 24-36 cystatin 12, pseudogene Homo sapiens 196-204 3558772-4 1986 Moreover, plasma levels of P, E2 and PRL in post-danazol cycles were similar to those found in control cycles and fell within the normal range in all cases except for one patient having hyperprolactinaemia. Danazol 49-56 cystatin 12, pseudogene Homo sapiens 30-40 3009450-13 1986 3) In vesicles containing choline, K+, Na+, or Li+, the rate of E2(T1)----E1Na increases in the order given. Choline 26-33 cystatin 12, pseudogene Homo sapiens 64-78 2937655-5 1986 In hMG-treated women, there were significant correlations between serum E2 and P concentrations and the number of the mature follicles observed before ovulation (both P less than 0.01). Menotropins 3-6 cystatin 12, pseudogene Homo sapiens 72-80 3758383-9 1986 The steroid-impregnated polysiloxane vaginal ring and cylinder system provided continuous and sustained hormone release, morphologically and endocrinologically normal endometrium, serum levels of E2 and P within the normal range for the entire menstrual cycle, and a convenient and physiologic therapeutic alternative to oral, vaginal, or intramuscular steroid replacement. Steroids 4-11 cystatin 12, pseudogene Homo sapiens 196-204 3637156-6 1986 Incubation of the native PDC in the presence of [2-14C]pyruvate leads to rapid uptake of radiolabel, presumably as acetyl groups, into both E2 and protein X. [2-14c]pyruvate 48-63 cystatin 12, pseudogene Homo sapiens 140-156 3968538-5 1985 [3H]Mannose-labelled E1, E2, GP59(E1) and GP43(E2) were digested with Pronase and the glycopeptides separated by gel filtration. Tritium 1-3 cystatin 12, pseudogene Homo sapiens 42-50 3864641-3 1985 Synthesis of PGE2 by oestrogen-positive and malignant tumours was significantly higher than by oestrogen-negative tumours, suggesting a correlation between prostaglandin E2 and receptor status. Dinoprostone 13-17 cystatin 12, pseudogene Homo sapiens 170-185 2948019-6 1986 Hydrophobic labeling of Ca-ATPase in sarcoplasmic reticulum vesicles with the photoactivable reagent trifluoromethyl-[125I]iodophenyl-diazirine indicated that E2 and E2V states are more exposed to the membrane phase than E1 and E1P (Ca2+-occluded) states. trifluoromethyl-[125i]iodophenyl-diazirine 101-143 cystatin 12, pseudogene Homo sapiens 159-169 3931686-8 1985 Immunoreactive peaks that co-migrated with dihomoprostaglandins E2 and F2 alpha were identified with antisera against prostaglandin E2 and prostaglandin F2 alpha, respectively. dihomoprostaglandins e2 43-66 cystatin 12, pseudogene Homo sapiens 132-161 3924118-3 1985 Other prostaglandins (I2, E2, D2) also activate cyclase without the addition of GTP. Prostaglandins 6-20 cystatin 12, pseudogene Homo sapiens 26-32 3924118-3 1985 Other prostaglandins (I2, E2, D2) also activate cyclase without the addition of GTP. Iodine 22-25 cystatin 12, pseudogene Homo sapiens 26-32 3968538-5 1985 [3H]Mannose-labelled E1, E2, GP59(E1) and GP43(E2) were digested with Pronase and the glycopeptides separated by gel filtration. Mannose 4-11 cystatin 12, pseudogene Homo sapiens 42-50 3968538-7 1985 GP43(E2) contained glycopeptides in three size classes, R1.5, R2.1 and R2.7; E2 contained these and size class R3.3. Glycopeptides 19-32 cystatin 12, pseudogene Homo sapiens 0-8 7350188-5 1980 Significant negative correlations were noted between Ca:Cr and percent ideal weight and between Ca:Cr and E2 and E1 concentrations. Chromium 99-101 cystatin 12, pseudogene Homo sapiens 106-115 6321597-1 1983 A procedure using high performance liquid chromatography (HPLC) is described for the separation of major primary cyclooxygenase metabolites (prostacyclin metabolite-6ketoPGF1 alpha, thromboxane B2, and prostaglandins F2 alpha, E2, and D2), leukotrienes (C4, B4, and D4), monohydroxyeicosatetraenoic acids (15-, 11-, 12-, and 5HETEs), and free arachidonic acid. Epoprostenol 141-153 cystatin 12, pseudogene Homo sapiens 217-237 6402032-3 1983 On incubation with [3H]arachidonic acid we identified, using TLC radiochromatography and several solvent systems, prostaglandins F2 alpha and E2 and, predominantly, thromboxane B2 which could not be attributed to platelet contamination. [3h]arachidonic acid 19-39 cystatin 12, pseudogene Homo sapiens 129-144 6402386-6 1983 Our observations suggest that serum E2 and hCG levels will reflect the apparent adequacy of luteal function during hMG/hCG treatment cycles. Menotropins 115-118 cystatin 12, pseudogene Homo sapiens 36-46 7279985-0 1981 New N-substituted derivatives of E-2"- and E-3"- hydroxystilbazoles-(4) of potential antimicrobial activity. Nitrogen 0-1 cystatin 12, pseudogene Homo sapiens 33-36 6111633-2 1981 Production of prostaglandins F2 alpha, E2, and D2 was similar to that observed for the endometrium of women with normal periods (range 5--50 ml; median 11 ml). Prostaglandins 14-28 cystatin 12, pseudogene Homo sapiens 29-49 7328474-5 1981 The reason for the negative glucose load test with negative CST was probably related to hemodynamic changes induced by intra-amniotic bleeding following a bloody amniocentesis, and not to the lack of fetal energy substate. Glucose 28-35 cystatin 12, pseudogene Homo sapiens 60-63 6387908-5 1984 Leydig cells after exposure to E2 or hCG showed the highest fluorescence intensity; this intensity was reduced by treatment with Tamoxifen. Tamoxifen 129-138 cystatin 12, pseudogene Homo sapiens 31-40 7093235-6 1982 By contrast, the products of PE2 cleavage (E2 and E3) contained sialyl glycopeptides similar to those found in mature virus (S1, S2, and S3). Glycopeptides 71-84 cystatin 12, pseudogene Homo sapiens 43-52 7413989-3 1980 In eyes which the AH inflow rate had been accelerated by prior administration of acetylcholine plus eserine, PGE1, E2 and F2 alpha caused a lowering of the inflow rate as well as vascular dilatation. Acetylcholine 81-94 cystatin 12, pseudogene Homo sapiens 115-130 7414024-0 1980 Haemoglobin J Rovigo 53 alpha (E-2) aspartic acid alanin. aspartic acid alanin 36-56 cystatin 12, pseudogene Homo sapiens 12-34 7363143-1 1980 The effects on neuromuscular blockade by d-tubocurarine and succinylcholine of inhibition of prostaglandin biosynthesis by indomethacin and of intra-arterial administration of prostoglandins E2 and F2 alpha, before and after inhibition of prostoglandin biosynthesis, were evaluated in the cat sciatic-tibialis preparation. prostoglandin 176-189 cystatin 12, pseudogene Homo sapiens 191-206 7363143-7 1980 However, both prostaglandin E2 and F2 alpha may induce transmitter release at the neuromuscular junction that may be enhanced by indomethacin, thus antagonizing the non-depolarizing blockade of d-tubocurarine and potentiating the depolarizing blockade of succinylcholine. Indomethacin 129-141 cystatin 12, pseudogene Homo sapiens 28-43 7363143-7 1980 However, both prostaglandin E2 and F2 alpha may induce transmitter release at the neuromuscular junction that may be enhanced by indomethacin, thus antagonizing the non-depolarizing blockade of d-tubocurarine and potentiating the depolarizing blockade of succinylcholine. Tubocurarine 194-208 cystatin 12, pseudogene Homo sapiens 28-43 6934685-9 1980 A slow rise in the plasma concentrations of the E2 and F2 alpha metabolites was found some hours following initiation of treatment, possibly indicating an increased endogenous prostaglandin biosynthesis, probably secondary to the stimulated uterine contractility. Prostaglandins 176-189 cystatin 12, pseudogene Homo sapiens 48-63 7386260-0 1980 Radioimmunoassay of the main urinary metabolite of prostaglandin F2 alpha in normal subjects after oral administration of prostaglandins E2 and F2 alpha. Dinoprost 51-73 cystatin 12, pseudogene Homo sapiens 137-152 573262-4 1979 The yields of disulfated disaccharide (b-2) and monosulfated disaccharides (e-2-1 and e-2-3) indicated that 2-O-sulfates in L-iduronic acid residues of heparin were more libile than 6-O-sulfates in glucosamine residues to the dilute acid treatment, whereas the opposite was the case for the solvolysis. 2-o-sulfates 108-120 cystatin 12, pseudogene Homo sapiens 86-91 7363143-7 1980 However, both prostaglandin E2 and F2 alpha may induce transmitter release at the neuromuscular junction that may be enhanced by indomethacin, thus antagonizing the non-depolarizing blockade of d-tubocurarine and potentiating the depolarizing blockade of succinylcholine. Succinylcholine 255-270 cystatin 12, pseudogene Homo sapiens 28-43 492624-4 1979 Direct interference of danazol in the assays for E2 and T was excluded by in vitro experiments. Danazol 23-30 cystatin 12, pseudogene Homo sapiens 49-57 387146-0 1979 Effects of prostaglandins E2 and I2 on human lymphocyte transformation in the presence and absence of inhibitors of prostaglandin biosynthesis. Prostaglandins 11-24 cystatin 12, pseudogene Homo sapiens 26-35 156321-5 1979 The initial E2 and E3 serum concentrations were lower in women treated with dexamethasone than in controls, while T serum levels did not display any difference. Dexamethasone 76-89 cystatin 12, pseudogene Homo sapiens 12-20 573262-4 1979 The yields of disulfated disaccharide (b-2) and monosulfated disaccharides (e-2-1 and e-2-3) indicated that 2-O-sulfates in L-iduronic acid residues of heparin were more libile than 6-O-sulfates in glucosamine residues to the dilute acid treatment, whereas the opposite was the case for the solvolysis. Iduronic Acid 124-139 cystatin 12, pseudogene Homo sapiens 86-91 573262-4 1979 The yields of disulfated disaccharide (b-2) and monosulfated disaccharides (e-2-1 and e-2-3) indicated that 2-O-sulfates in L-iduronic acid residues of heparin were more libile than 6-O-sulfates in glucosamine residues to the dilute acid treatment, whereas the opposite was the case for the solvolysis. Heparin 152-159 cystatin 12, pseudogene Homo sapiens 86-91 687504-3 1978 3 Arachidonic acid, prostaglandins E2 and FSalpha, as measured by GC--MS, were significantly elevated at 24 h. Radioimmunoassay also showed increased PGF2alpha-like concentrations. Dinoprost 150-159 cystatin 12, pseudogene Homo sapiens 35-49 680407-0 1978 Stimulatory effects of prostaglandins E-1, E-2, and F-2-alpha on glucagon and insulin release in vitro. Glucagon 65-73 cystatin 12, pseudogene Homo sapiens 43-46 368707-0 1978 [Morphology of parietal cells of the stomach body after oral administration of methyl ester 15 s-15 methyloprostaglandin E-2 (m-PGE-2S)]. methyl ester 79-91 cystatin 12, pseudogene Homo sapiens 121-124 405188-1 1977 Various PG synthesis inhibitors potentiate the effects of PGE1, E2 and F2 alpha on isolated sphincter, dilator and ciliary muscles of the cat when added to the bath or injected intravenously. pg 8-10 cystatin 12, pseudogene Homo sapiens 64-79 340159-1 1978 In 12 patients requiring therapy with mechanical ventilation for acute respiratory failure, total static compliance (Cst) increased from 29 +/- 4 ml/cm H2O at a tidal volume (TV) of 5 ml/kg to 42 +/- 7 ml/cm H2O at a TV of 15 ml/kg. Water 152-155 cystatin 12, pseudogene Homo sapiens 117-120 340159-1 1978 In 12 patients requiring therapy with mechanical ventilation for acute respiratory failure, total static compliance (Cst) increased from 29 +/- 4 ml/cm H2O at a tidal volume (TV) of 5 ml/kg to 42 +/- 7 ml/cm H2O at a TV of 15 ml/kg. Water 208-211 cystatin 12, pseudogene Homo sapiens 117-120 340159-2 1978 Similarly, Cst increased from 42 +/- 7 ml/cm H2O to 52 +/- 8 ml/cm H2O between 0 and 6 cm H2O of positive end-expiratory pressure (PEEP). Water 45-48 cystatin 12, pseudogene Homo sapiens 11-14 340159-2 1978 Similarly, Cst increased from 42 +/- 7 ml/cm H2O to 52 +/- 8 ml/cm H2O between 0 and 6 cm H2O of positive end-expiratory pressure (PEEP). Water 67-70 cystatin 12, pseudogene Homo sapiens 11-14 340159-2 1978 Similarly, Cst increased from 42 +/- 7 ml/cm H2O to 52 +/- 8 ml/cm H2O between 0 and 6 cm H2O of positive end-expiratory pressure (PEEP). Water 67-70 cystatin 12, pseudogene Homo sapiens 11-14 913699-4 1977 The mass spectrum showed molecular ions at m/e 342, 416 and 504 which correspond to the TMSi derivatives of Estrone (E-1), Estradiol (E-2) and Estriol (E-3) respectively. Estrone 108-115 cystatin 12, pseudogene Homo sapiens 134-137 913699-4 1977 The mass spectrum showed molecular ions at m/e 342, 416 and 504 which correspond to the TMSi derivatives of Estrone (E-1), Estradiol (E-2) and Estriol (E-3) respectively. Estradiol 123-132 cystatin 12, pseudogene Homo sapiens 134-137 6255891-4 1980 Prostaglandins (E2 and F2 alpha) did not influence the level of cAMP in lymphocytes affected previously by lectins (PHA and Con A), except Con A+PGF2 alpha scheme. Prostaglandins 0-14 cystatin 12, pseudogene Homo sapiens 16-31 192613-11 1977 At iodide equilibrium, thryotropin, prostaglandins E1 and E2 and long-acting thyroid stimulator (LATS), induce a fast release of iodide. Iodides 3-9 cystatin 12, pseudogene Homo sapiens 58-95 192613-11 1977 At iodide equilibrium, thryotropin, prostaglandins E1 and E2 and long-acting thyroid stimulator (LATS), induce a fast release of iodide. thryotropin 23-34 cystatin 12, pseudogene Homo sapiens 58-95 192613-11 1977 At iodide equilibrium, thryotropin, prostaglandins E1 and E2 and long-acting thyroid stimulator (LATS), induce a fast release of iodide. Iodides 129-135 cystatin 12, pseudogene Homo sapiens 58-95 1250539-5 1976 Release of P and E2 into the medium was significantly increased by the addition of hCG and PGF2alpha in some cases. Dinoprost 91-100 cystatin 12, pseudogene Homo sapiens 11-19 59814-10 1976 The presence of the complete carbohydrate moiety is crucial for the cleavage of NVP 68 into the envelope proteins E2 and E3 and, thus, for virus maturation. Carbohydrates 29-41 cystatin 12, pseudogene Homo sapiens 114-123 1159039-5 1975 Peak plasma E-2 level was 188.2 +/- 42.1 pg/ml in the control cycle and 74.4 +/- 15.3 pg/ml during paramethasone treatment (P is less than 0.05). Paramethasone 99-112 cystatin 12, pseudogene Homo sapiens 12-15 1159039-12 1975 These results suggest that: 1) Paramethasone may block E-2 synthesis at the ovarian level and , 2) Ovulation may still occur even in the presence of E-2 and LH plasma concentrations lower than those occurring in the normal menstrual cycle. Paramethasone 31-44 cystatin 12, pseudogene Homo sapiens 55-58 805673-3 1975 The prostaglandin generated and released in the kidney is predominantly E-2. Prostaglandins 4-17 cystatin 12, pseudogene Homo sapiens 72-75 805673-5 1975 Endogenous prostaglandin E-2 production contributes to the regulation of blood pressure by (1) opposing the vasoconstrictor and antidiuretic actions of circulating pressor hormones; (2) braking the release of norepinephrine from vasoconstrictor nerves; and (3) participating in the control extracellular fluid volume through its renal hemodynamic actions. Norepinephrine 209-223 cystatin 12, pseudogene Homo sapiens 25-28 1117058-1 1975 Ingestion of a single tablet containing 2 mg micronized 17beta-estradiol (E-2) produced marked increases in the serum concentrations of E-2 and estrone (E-1) in 9 postmenopausal women. Estradiol 56-72 cystatin 12, pseudogene Homo sapiens 74-77 163841-1 1975 Specific receptor binding of estradiol (E-2) and dihydrotestosterone (DHT) was studied in human myometrial tissue and in human mammary cancer tissue. Estradiol 29-38 cystatin 12, pseudogene Homo sapiens 40-43 163841-2 1975 The inhibition of binding for E-2 and DHT by E-2, testosterone (T), DHT, dehydroepiandosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), androstendione (A) and 5-androstene-3beta, 17beta-diol (Adiol) was tested with the use of dextran-coated charcoal separation of bound and free E-2, respectively, and DHT. Testosterone 50-62 cystatin 12, pseudogene Homo sapiens 30-33 163841-2 1975 The inhibition of binding for E-2 and DHT by E-2, testosterone (T), DHT, dehydroepiandosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), androstendione (A) and 5-androstene-3beta, 17beta-diol (Adiol) was tested with the use of dextran-coated charcoal separation of bound and free E-2, respectively, and DHT. Dihydrotestosterone 38-41 cystatin 12, pseudogene Homo sapiens 45-48 163841-2 1975 The inhibition of binding for E-2 and DHT by E-2, testosterone (T), DHT, dehydroepiandosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), androstendione (A) and 5-androstene-3beta, 17beta-diol (Adiol) was tested with the use of dextran-coated charcoal separation of bound and free E-2, respectively, and DHT. Dihydrotestosterone 38-41 cystatin 12, pseudogene Homo sapiens 45-48 163841-2 1975 The inhibition of binding for E-2 and DHT by E-2, testosterone (T), DHT, dehydroepiandosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), androstendione (A) and 5-androstene-3beta, 17beta-diol (Adiol) was tested with the use of dextran-coated charcoal separation of bound and free E-2, respectively, and DHT. Dehydroepiandrosterone 73-94 cystatin 12, pseudogene Homo sapiens 30-33 163841-2 1975 The inhibition of binding for E-2 and DHT by E-2, testosterone (T), DHT, dehydroepiandosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), androstendione (A) and 5-androstene-3beta, 17beta-diol (Adiol) was tested with the use of dextran-coated charcoal separation of bound and free E-2, respectively, and DHT. Dehydroepiandrosterone 96-100 cystatin 12, pseudogene Homo sapiens 30-33 163841-2 1975 The inhibition of binding for E-2 and DHT by E-2, testosterone (T), DHT, dehydroepiandosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), androstendione (A) and 5-androstene-3beta, 17beta-diol (Adiol) was tested with the use of dextran-coated charcoal separation of bound and free E-2, respectively, and DHT. Dehydroepiandrosterone Sulfate 103-133 cystatin 12, pseudogene Homo sapiens 30-33 1208380-2 1975 The yield of previtamins and, consequently, vitamins D was higher with the use of erythemic lamps with luminophore E-2 and luminophore E-3 than with the use of lamps PRK-2. Vitamin D 44-54 cystatin 12, pseudogene Homo sapiens 115-118 1077783-0 1975 Effect of prostaglandins (E2 and A2) on the enzymatic reaction of human renin in isolated homologous system and with added normal and hypertensive plasma. Prostaglandins 10-24 cystatin 12, pseudogene Homo sapiens 26-35 1117058-1 1975 Ingestion of a single tablet containing 2 mg micronized 17beta-estradiol (E-2) produced marked increases in the serum concentrations of E-2 and estrone (E-1) in 9 postmenopausal women. Estradiol 56-72 cystatin 12, pseudogene Homo sapiens 136-139 1117058-1 1975 Ingestion of a single tablet containing 2 mg micronized 17beta-estradiol (E-2) produced marked increases in the serum concentrations of E-2 and estrone (E-1) in 9 postmenopausal women. Estrone 144-151 cystatin 12, pseudogene Homo sapiens 74-77 33884811-9 2021 Simultaneously, the concentration of macromolecular organic substances in the EPS of the excess sludge increased from 40.6 mg g-1 to 54.6 mg g-1, while the CST increased from 15 s to 17 s after ozone treatment. Ozone 194-199 cystatin 12, pseudogene Homo sapiens 156-159 163841-2 1975 The inhibition of binding for E-2 and DHT by E-2, testosterone (T), DHT, dehydroepiandosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), androstendione (A) and 5-androstene-3beta, 17beta-diol (Adiol) was tested with the use of dextran-coated charcoal separation of bound and free E-2, respectively, and DHT. Androstenedione 144-158 cystatin 12, pseudogene Homo sapiens 30-33 163841-2 1975 The inhibition of binding for E-2 and DHT by E-2, testosterone (T), DHT, dehydroepiandosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), androstendione (A) and 5-androstene-3beta, 17beta-diol (Adiol) was tested with the use of dextran-coated charcoal separation of bound and free E-2, respectively, and DHT. 5-androstene-3beta 167-185 cystatin 12, pseudogene Homo sapiens 30-33 163841-2 1975 The inhibition of binding for E-2 and DHT by E-2, testosterone (T), DHT, dehydroepiandosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), androstendione (A) and 5-androstene-3beta, 17beta-diol (Adiol) was tested with the use of dextran-coated charcoal separation of bound and free E-2, respectively, and DHT. 17beta-diol 187-198 cystatin 12, pseudogene Homo sapiens 30-33 163841-2 1975 The inhibition of binding for E-2 and DHT by E-2, testosterone (T), DHT, dehydroepiandosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), androstendione (A) and 5-androstene-3beta, 17beta-diol (Adiol) was tested with the use of dextran-coated charcoal separation of bound and free E-2, respectively, and DHT. Dextrans 234-241 cystatin 12, pseudogene Homo sapiens 30-33 163841-2 1975 The inhibition of binding for E-2 and DHT by E-2, testosterone (T), DHT, dehydroepiandosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), androstendione (A) and 5-androstene-3beta, 17beta-diol (Adiol) was tested with the use of dextran-coated charcoal separation of bound and free E-2, respectively, and DHT. Dihydrotestosterone 68-71 cystatin 12, pseudogene Homo sapiens 30-33 163841-3 1975 The percentage of binding inhibition was calculated with reference to the inhibition obtained with nafoxidine in a molar concentration ratio of 1,000 for E-2 binding, respectively, with cyproterone acetate in a molar concentration ratio of 10,000 for DHT binding. Nafoxidine 99-109 cystatin 12, pseudogene Homo sapiens 154-157 163841-6 1975 A 50% inhibition of E-2 binding, in myometrial as well as in tumor tissue, required a molar concentration ratio of 40 for Adiol, of more than 2,000 for DHEA. Dehydroepiandrosterone 152-156 cystatin 12, pseudogene Homo sapiens 20-23 163841-8 1975 With regard to DHT binding, Adiol is more active than E-2 and less active than T. Of the substances tested Adiol is therefore the only one which exerts a significant inhibiting influence at a molar ratio not far beyond the physiological range. Androstenediol 107-112 cystatin 12, pseudogene Homo sapiens 54-57 125040-13 1975 A positive correlation was found between LH levels and both E2 and E1 concentrations in the patients with PCO. Luteinizing Hormone 41-43 cystatin 12, pseudogene Homo sapiens 60-69 1170202-2 1975 Synthesis of derivatives of aldgarose, a component of aldgamycin E-2. aldgarose 28-37 cystatin 12, pseudogene Homo sapiens 65-68 33881860-0 2021 Copper-Catalyzed Lactamization of (E)-2-(2-Bromophenyl)-3-arylacrylamides for the Synthesis of (E)-3-Arylideneindolin-2-ones. Copper 0-6 cystatin 12, pseudogene Homo sapiens 34-39 33881860-1 2021 A copper-catalyzed, ligand-free intramolecular C-N coupling of (E)-2-(2-bromophenyl)-3-arylacrylamides has been developed. Copper 2-8 cystatin 12, pseudogene Homo sapiens 63-68 33912037-7 2021 In addition, 3"-SL could reverse the increased levels of inflammatory markers such as nitrite, prostaglandin E2, inducible nitric oxide synthase, cyclooxygenase-2, IL-1beta, and IL-6 in IL-1beta-stimulated chondrocytic cells. 3'-sialyllactose 13-18 cystatin 12, pseudogene Homo sapiens 109-144 33631667-2 2021 Furthermore, the human body secretes various malodorous compounds as waste products of metabolism, including trans-2-nonenal ((E)-2-nonenal), the amount of which increases with aging. malodorous 45-55 cystatin 12, pseudogene Homo sapiens 126-131 33650791-7 2021 Particularly, we observed that sirtinol interferes with E2/ERalpha and IGF1R (insulin growth factor 1 receptor) pathways by decreasing receptors expression. sirtinol 31-39 cystatin 12, pseudogene Homo sapiens 56-66 31132367-8 2021 The physiological/therapeutic doses of E2/EE2 that activated p38 were most effectively challenged by R-eq at >=fM concentrations. r-eq 101-105 cystatin 12, pseudogene Homo sapiens 39-45 33288957-2 2021 Various combinations of E2 and E3 enzymes accomplish chain formation by forging isopeptide bonds between the C terminus of their transiently linked donor ubiquitin and a specific nucleophilic amino acid on the acceptor ubiquitin, yet it is unknown whether the fundamental feature of most acceptors-the lysine side chain-affects catalysis. Lysine 302-308 cystatin 12, pseudogene Homo sapiens 24-33 32657203-2 2020 The enzyme galactosylceramide (cerebroside) sulphotransferase (CST) catalyses the transfer of a sulphate group from 3"-phosphoadenosine-5"-phosphosulphate (PAPS) to cerebrosides producing sulphatides. Galactosylceramides 11-29 cystatin 12, pseudogene Homo sapiens 63-66 33306780-10 2021 Amplifex Diene derivatized E2 and estrone (E1) was found to be stable for over 6 months, both refrigerated and frozen. amplifex diene 0-14 cystatin 12, pseudogene Homo sapiens 27-45 33343296-4 2020 Here we investigated the biophysical and molecular properties of TauQ336H in living cells by the employment of the conformational Tau biosensor CST. tauq336h 65-73 cystatin 12, pseudogene Homo sapiens 144-147 32657203-2 2020 The enzyme galactosylceramide (cerebroside) sulphotransferase (CST) catalyses the transfer of a sulphate group from 3"-phosphoadenosine-5"-phosphosulphate (PAPS) to cerebrosides producing sulphatides. Cerebrosides 31-42 cystatin 12, pseudogene Homo sapiens 63-66 32657203-2 2020 The enzyme galactosylceramide (cerebroside) sulphotransferase (CST) catalyses the transfer of a sulphate group from 3"-phosphoadenosine-5"-phosphosulphate (PAPS) to cerebrosides producing sulphatides. Sulfates 96-104 cystatin 12, pseudogene Homo sapiens 63-66 32657203-2 2020 The enzyme galactosylceramide (cerebroside) sulphotransferase (CST) catalyses the transfer of a sulphate group from 3"-phosphoadenosine-5"-phosphosulphate (PAPS) to cerebrosides producing sulphatides. 3"-phosphoadenosine-5"-phosphosulphate 116-154 cystatin 12, pseudogene Homo sapiens 63-66 32657203-2 2020 The enzyme galactosylceramide (cerebroside) sulphotransferase (CST) catalyses the transfer of a sulphate group from 3"-phosphoadenosine-5"-phosphosulphate (PAPS) to cerebrosides producing sulphatides. PAPS 156-160 cystatin 12, pseudogene Homo sapiens 63-66 32657203-2 2020 The enzyme galactosylceramide (cerebroside) sulphotransferase (CST) catalyses the transfer of a sulphate group from 3"-phosphoadenosine-5"-phosphosulphate (PAPS) to cerebrosides producing sulphatides. Cerebrosides 165-177 cystatin 12, pseudogene Homo sapiens 63-66 32657203-2 2020 The enzyme galactosylceramide (cerebroside) sulphotransferase (CST) catalyses the transfer of a sulphate group from 3"-phosphoadenosine-5"-phosphosulphate (PAPS) to cerebrosides producing sulphatides. Sulfoglycosphingolipids 188-199 cystatin 12, pseudogene Homo sapiens 63-66 32657203-4 2020 To identify competitive CST inhibitors, we synthesised and investigated analogues of the substrate galactosylceramide with variations at the anomeric position, the acyl substituent and the carbohydrate moiety, and investigated their structure-activity relationships. Galactosylceramides 99-117 cystatin 12, pseudogene Homo sapiens 24-27 32657203-5 2020 While most of the compounds behaved as substrates, alpha-galactosylceramide 16 was identified as the first competitive CST inhibitor. alpha-galactosylceramide 51-75 cystatin 12, pseudogene Homo sapiens 119-122 32757462-5 2020 In the presence of cycloheximide, E2 and G1 treatment counteracted PFKFB3 degradation over time, whereas E2-induced PFKFB3 stabilization was abolished by the GPER antagonist G15. Cycloheximide 19-32 cystatin 12, pseudogene Homo sapiens 34-43 32740481-1 2020 OBJECTIVE: To examine responder rates and vasomotor symptom-free days with oral 17beta-estradiol/progesterone (E2/P4; TX-001HR) versus placebo in the REPLENISH trial. Estradiol 80-96 cystatin 12, pseudogene Homo sapiens 111-116 32740481-1 2020 OBJECTIVE: To examine responder rates and vasomotor symptom-free days with oral 17beta-estradiol/progesterone (E2/P4; TX-001HR) versus placebo in the REPLENISH trial. Progesterone 97-109 cystatin 12, pseudogene Homo sapiens 111-116 32500111-11 2020 We measured and confirmed ultra-low E2 and E1 concentrations in sera from patients on the aromatase inhibitors letrozole or exemestane. Letrozole 111-120 cystatin 12, pseudogene Homo sapiens 36-45 30817238-5 2020 Results showed that the best Fe2+/H2O2 was equal to 0.8 corresponding to 2.1 s of CST, 2.1 1013 m kg-1 of SRF and 3.1% of DS. ammonium ferrous sulfate 29-33 cystatin 12, pseudogene Homo sapiens 82-85 30817238-5 2020 Results showed that the best Fe2+/H2O2 was equal to 0.8 corresponding to 2.1 s of CST, 2.1 1013 m kg-1 of SRF and 3.1% of DS. Hydrogen Peroxide 34-38 cystatin 12, pseudogene Homo sapiens 82-85 30817238-7 2020 Results showed that performing Fenton process with a concentration of H2O2 and Fe2+ of, respectively, 6000 and 5000 mg L-1 the SRF and CST could be reduced up to 88% and 76%, respectively, and a DS equal to 3.1% could be obtained. Hydrogen Peroxide 70-74 cystatin 12, pseudogene Homo sapiens 135-138 30817238-7 2020 Results showed that performing Fenton process with a concentration of H2O2 and Fe2+ of, respectively, 6000 and 5000 mg L-1 the SRF and CST could be reduced up to 88% and 76%, respectively, and a DS equal to 3.1% could be obtained. ammonium ferrous sulfate 79-83 cystatin 12, pseudogene Homo sapiens 135-138 30817238-7 2020 Results showed that performing Fenton process with a concentration of H2O2 and Fe2+ of, respectively, 6000 and 5000 mg L-1 the SRF and CST could be reduced up to 88% and 76%, respectively, and a DS equal to 3.1% could be obtained. Deuterium 195-197 cystatin 12, pseudogene Homo sapiens 135-138 32120219-8 2020 A reasonable catalytic pathway of E2 and HA involving MnO2 nanozyme was proposed. manganese dioxide 54-58 cystatin 12, pseudogene Homo sapiens 34-43 32500111-11 2020 We measured and confirmed ultra-low E2 and E1 concentrations in sera from patients on the aromatase inhibitors letrozole or exemestane. exemestane 124-134 cystatin 12, pseudogene Homo sapiens 36-45 32167275-6 2020 A modified field emission theory of graphene with curves of ln(I/E^3/2)~1/E and ln(I/E^3)~1/E^2 in high- and low field regimes respectively has been used to analyze the phenomenon. Graphite 36-44 cystatin 12, pseudogene Homo sapiens 92-95 32167275-7 2020 The graphene"s line current density of 2-dimensional structure and its special energy dispersion relation at K state of Dirac point makes the curves of ln(I/E^3/2)~1/E and ln(I/E^3)~1/E^2 to show an up-bending features, which lead to the improvement of the field electron emission tunneling efficiency as the applied electric field increases. Graphite 4-12 cystatin 12, pseudogene Homo sapiens 184-187 31081545-7 2019 In comparison, the six-element model with all the viscoelastic parameters performed the best and was determined to predict TVB-N content with correlation coefficient in the prediction set (RP ) of 0.891 and root mean squared error in the prediction set (RMSEP) of 1.467 mg/100 g. Based on the results of parameter combinations, combination (E2 , E3 , E1 , eta1 , eta2 ) from the six-element model performed the best, which was comparatively inferior to all the viscoelastic parameters of the six-element model. tvb-n 123-128 cystatin 12, pseudogene Homo sapiens 341-353 31263248-1 2020 The effect of nomegestrol acetate/estradiol (NOMAC/E2) on clitoral and uterine vascularization has never been evaluated. nomegestrol acetate 14-33 cystatin 12, pseudogene Homo sapiens 45-53 31263248-1 2020 The effect of nomegestrol acetate/estradiol (NOMAC/E2) on clitoral and uterine vascularization has never been evaluated. Estradiol 34-43 cystatin 12, pseudogene Homo sapiens 45-53 31931141-17 2020 Decreased enrichment in the TCA cycle of E2 and E3 astrocytes is suggestive of increased oxidation and non-glucose derived anaplerosis, which could be fueling mitochondrial ATP production. TCA 11a 28-31 cystatin 12, pseudogene Homo sapiens 41-50 31931141-17 2020 Decreased enrichment in the TCA cycle of E2 and E3 astrocytes is suggestive of increased oxidation and non-glucose derived anaplerosis, which could be fueling mitochondrial ATP production. Glucose 107-114 cystatin 12, pseudogene Homo sapiens 41-50 31931141-17 2020 Decreased enrichment in the TCA cycle of E2 and E3 astrocytes is suggestive of increased oxidation and non-glucose derived anaplerosis, which could be fueling mitochondrial ATP production. Adenosine Triphosphate 173-176 cystatin 12, pseudogene Homo sapiens 41-50 31579960-7 2020 H89 blocked the regulation of Genistein on the secretion of E2 and P4 , and alleviated the ascending of Star and Cyp19a1 elicited by Genistein. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 0-3 cystatin 12, pseudogene Homo sapiens 60-69 31579960-7 2020 H89 blocked the regulation of Genistein on the secretion of E2 and P4 , and alleviated the ascending of Star and Cyp19a1 elicited by Genistein. Genistein 30-39 cystatin 12, pseudogene Homo sapiens 60-69 31364889-6 2019 Minimal increases of potential clinical importance were observed in total cholesterol, triglycerides, and glucose at month 12 with E2/P4 (1-4%, 6-11%, and 1%, respectively) and placebo (3%, 7%, and 2%, respectively). Cholesterol 74-85 cystatin 12, pseudogene Homo sapiens 131-136 31364889-6 2019 Minimal increases of potential clinical importance were observed in total cholesterol, triglycerides, and glucose at month 12 with E2/P4 (1-4%, 6-11%, and 1%, respectively) and placebo (3%, 7%, and 2%, respectively). Triglycerides 87-100 cystatin 12, pseudogene Homo sapiens 131-136 31364889-6 2019 Minimal increases of potential clinical importance were observed in total cholesterol, triglycerides, and glucose at month 12 with E2/P4 (1-4%, 6-11%, and 1%, respectively) and placebo (3%, 7%, and 2%, respectively). Glucose 106-113 cystatin 12, pseudogene Homo sapiens 131-136 31913228-1 2020 OBJECTIVE: The aim of the study was to evaluate the effect of a single-capsule 17beta-estradiol/progesterone (E2/P4), TX-001HR, on endometrial safety, to report on amenorrhea and bleeding patterns of users, and to identify predictors of amenorrhea. Estradiol 79-95 cystatin 12, pseudogene Homo sapiens 110-115 31913228-1 2020 OBJECTIVE: The aim of the study was to evaluate the effect of a single-capsule 17beta-estradiol/progesterone (E2/P4), TX-001HR, on endometrial safety, to report on amenorrhea and bleeding patterns of users, and to identify predictors of amenorrhea. Progesterone 96-108 cystatin 12, pseudogene Homo sapiens 110-115 31614463-6 2019 Our findings suggest a hypothetical positive feedback loop between E2/ERalpha and HSF1 signaling, which may support the growth of estrogen-dependent tumors. Estrogens 130-138 cystatin 12, pseudogene Homo sapiens 67-77 29783993-3 2018 Despite this fact, the antiviral properties of CST, one of such flavonoids, against the influenza virus has not been reported. Flavonoids 64-74 cystatin 12, pseudogene Homo sapiens 47-50 30708032-14 2019 Moreover, the enhanced values of E2/testosterone and the level of DHT in serum were also strongly inhibited in CS group compared with those in BPH groups. Cesium 111-113 cystatin 12, pseudogene Homo sapiens 33-48 30945546-3 2019 Indeed, certain aldehydes, such as hexanal, E-2-nonenal, and E, E-2,4-decadienal, serve as key odorants in a range of our foods and drinks. Aldehydes 16-25 cystatin 12, pseudogene Homo sapiens 44-47 30945546-3 2019 Indeed, certain aldehydes, such as hexanal, E-2-nonenal, and E, E-2,4-decadienal, serve as key odorants in a range of our foods and drinks. Aldehydes 16-25 cystatin 12, pseudogene Homo sapiens 64-67 25905374-3 2000 The diversity and complexity of the actions of testosterone (and its metabolites E2 and DHT) and DHEA on the vasculature reflect the multiple cellular targets in the vessel wall, differences between species, gender, concomitant disease and, most importantly, level/dosage of testosterone exposure. Testosterone 47-59 cystatin 12, pseudogene Homo sapiens 81-91 25905374-3 2000 The diversity and complexity of the actions of testosterone (and its metabolites E2 and DHT) and DHEA on the vasculature reflect the multiple cellular targets in the vessel wall, differences between species, gender, concomitant disease and, most importantly, level/dosage of testosterone exposure. Testosterone 275-287 cystatin 12, pseudogene Homo sapiens 81-91 30325391-3 2018 A stereoselective 5-exo-trig Mizoroki-Heck reaction of the acyloxy iodoalkenes generates the target E-2(3H)-furanones. 5-exo-trig 18-28 cystatin 12, pseudogene Homo sapiens 100-103 30325391-3 2018 A stereoselective 5-exo-trig Mizoroki-Heck reaction of the acyloxy iodoalkenes generates the target E-2(3H)-furanones. acyloxy iodoalkenes 59-78 cystatin 12, pseudogene Homo sapiens 100-103 29803496-8 2018 We observed that water CST extracts are rich in phenolic content, whereas for CTA the olive oil was the elective extraction solvent. Water 17-22 cystatin 12, pseudogene Homo sapiens 23-26 29803496-9 2018 As expected, water CST extracts were the most effective in reducing hydrogen peroxide-induced oxidative stress in both cell lines and in vitro assays. Water 13-18 cystatin 12, pseudogene Homo sapiens 19-22 29803496-9 2018 As expected, water CST extracts were the most effective in reducing hydrogen peroxide-induced oxidative stress in both cell lines and in vitro assays. Hydrogen Peroxide 68-85 cystatin 12, pseudogene Homo sapiens 19-22 29803496-10 2018 Furthermore, both CST and CTA water extracts reduced the LDH activity in HCT116 cells challenged with hydrogen peroxide and LPS-induced MDA levels in rat colon specimens. Hydrogen Peroxide 102-119 cystatin 12, pseudogene Homo sapiens 18-21 30678022-8 2019 %MEHP was associated positively with FSH (beta = 0.118) and LH (beta = 0.099), but negatively with TEST/LH (beta = -0.086) and TEST/E2 (beta = -0.109). mono-(2-ethylhexyl)phthalate 1-5 cystatin 12, pseudogene Homo sapiens 127-134 31622061-7 2019 Taking into account these results, the oligonucleotide primers specific to genotypes I1, I2, I3 and E1, E2, E3 were designed. Oligonucleotides 39-54 cystatin 12, pseudogene Homo sapiens 89-110 30524952-7 2018 We report that significant changes in metabolites induced by E2 and SFN were associated with differences in glycolysis and energy metabolism, and also amino acid, purine, and folic acid metabolism. purine 163-169 cystatin 12, pseudogene Homo sapiens 61-71 30524952-7 2018 We report that significant changes in metabolites induced by E2 and SFN were associated with differences in glycolysis and energy metabolism, and also amino acid, purine, and folic acid metabolism. Folic Acid 175-185 cystatin 12, pseudogene Homo sapiens 61-71 30500143-2 2018 Cox proportional hazards models were used to compare AMC risk for (1) ADA, ETN, and UST (separately) vs CST/topical, and (2) ADA vs other biologic therapies (ETN, UST, and IFX combined). 7-amino-4-methylcoumarin 53-56 cystatin 12, pseudogene Homo sapiens 104-107 29326052-3 2018 Our study was aimed to analyse the effect of female sex hormones (oestrogen - E2 and progesterone - Pg) on cough sensitivity measured by inhalation of capsaicin in follicular and luteal phases of menstrual cycle, characterized by significantly different concentrations of sex hormones. Capsaicin 151-160 cystatin 12, pseudogene Homo sapiens 78-102 30270563-4 2018 Our results showed that salidroside significantly inhibited the production of nitric oxide and prostaglandin E-2, as well as suppressed the expression of inducible nitric oxide synthase and cyclooxygenase-2 in IL-1beta-stimulated chondrocytes ( P < .05). rhodioloside 24-35 cystatin 12, pseudogene Homo sapiens 109-112 29687179-11 2018 Adjusting for TBW, CST resulted in a 27.8% reduction in OT (44-min savings, p < 0.001) compared to SST. tbw 14-17 cystatin 12, pseudogene Homo sapiens 19-22 28101853-7 2017 For a better understanding, the CST Microwave Studio software, based on the finite element method (FEM), was applied to simulate the absorption characteristics of the structures on the graphene substrate. Graphite 185-193 cystatin 12, pseudogene Homo sapiens 32-35 29327779-5 2018 To overcome these problems, ethyl-2,5-dihydroxybenzoate (E-2,5-DHB), a drug that promotes bone formation and inhibits bone resorption, was used. Ethyl 2,5-dihydroxybenzoate 28-55 cystatin 12, pseudogene Homo sapiens 57-60 29327779-6 2018 E-2,5-DHB-incorporating titanium (Ti) implants using poly(lactic-co-glycolic acid) (PLGA) coating for local delivery of E-2,5-DHB were developed and the effects on bone healing of femoral defects were evaluated in an osteoporotic model. Polylactic Acid-Polyglycolic Acid Copolymer 53-82 cystatin 12, pseudogene Homo sapiens 0-3 29327779-6 2018 E-2,5-DHB-incorporating titanium (Ti) implants using poly(lactic-co-glycolic acid) (PLGA) coating for local delivery of E-2,5-DHB were developed and the effects on bone healing of femoral defects were evaluated in an osteoporotic model. Polylactic Acid-Polyglycolic Acid Copolymer 53-82 cystatin 12, pseudogene Homo sapiens 120-123 28485628-3 2017 The primary purposes of the study were to evaluate whether a 12-month-treatment with the combined OC containing micronized estradiol (1.5 mg, E2) plus nomegestrol acetate (2.5 mg, NOMAC) (E2/NOMAC) interfere on anthropometric indices (AI), body composition (BC) and psychological status (PS). 2-n-octyl-4-isothiazolin-3-one 98-100 cystatin 12, pseudogene Homo sapiens 188-196 28485628-3 2017 The primary purposes of the study were to evaluate whether a 12-month-treatment with the combined OC containing micronized estradiol (1.5 mg, E2) plus nomegestrol acetate (2.5 mg, NOMAC) (E2/NOMAC) interfere on anthropometric indices (AI), body composition (BC) and psychological status (PS). nomegestrol acetate 151-170 cystatin 12, pseudogene Homo sapiens 188-196 29416786-11 2018 This study has paved a foundation for elucidating TAM anti-breast cancer mechanisms in E2/ER-dependent and independent pathways. Tamoxifen 50-53 cystatin 12, pseudogene Homo sapiens 87-92 28213978-6 2017 Finally, the inhibitory effect of E2 and DHT on RANKL membrane association was counteracted by the MMP inhibitor NNGH, and the effect of E2 (and not DHT) was antagonized by the Src inhibitor SU6656. NNGH 113-117 cystatin 12, pseudogene Homo sapiens 34-44 28863192-8 2017 In cells treated with calcium blocker (BATPA), the inhibitory effect of E2/ERbeta on ISO-induced Ca2+ influx and hypertrophic effects were totally blocked suggesting that E2/ERbeta inhibited calcineurin activity to activate I-1 protein and suppress PP1, then induce PLB protein phosphorylation and activation, resulting in Ca2+ reuptake into sarcoplasmic reticulum through SR Ca2+ cycling modification. batpa 39-44 cystatin 12, pseudogene Homo sapiens 171-180 29338386-11 2017 CONCLUSIONS: This is the first report to demonstrate, on a molecular level, that E2/ERalpha signaling facilitates bilirubin metabolism in regenerating liver. Bilirubin 114-123 cystatin 12, pseudogene Homo sapiens 81-91 28863192-7 2017 Furthermore, by testing with the calcineurin inhibitor (CsA), it was confirmed that calcineurin acted as a key mediator for the anti-hypertrophic effect of E2/ERbeta. Cyclosporine 56-59 cystatin 12, pseudogene Homo sapiens 156-165 27459535-3 2016 HYPOTHESIS: Because E2 stimulates GH secretion, putatively via the nuclear estrogen receptor-alpha and E2 and GH fall with menopause, we postulated that diminished endogenous E2 contributes to low GH output in older women. Estradiol 20-22 cystatin 12, pseudogene Homo sapiens 103-112 28863192-8 2017 In cells treated with calcium blocker (BATPA), the inhibitory effect of E2/ERbeta on ISO-induced Ca2+ influx and hypertrophic effects were totally blocked suggesting that E2/ERbeta inhibited calcineurin activity to activate I-1 protein and suppress PP1, then induce PLB protein phosphorylation and activation, resulting in Ca2+ reuptake into sarcoplasmic reticulum through SR Ca2+ cycling modification. batpa 39-44 cystatin 12, pseudogene Homo sapiens 72-81 27940299-4 2017 Moreover, like E2 and G1, Cd leads to a rapid activation of ERK/AKT, and then nuclear translocation of NF-kappaB, increased expression of cyclin A and D1, and secretion of IL-8, all of which are significantly attenuated by GPER blockage or knock-down in both WRO and FRO cells. Cadmium 26-28 cystatin 12, pseudogene Homo sapiens 15-24 27997350-1 2017 OBJECTIVE: Serum concentrations of estradiol (E2) and testosterone (testo) measured by mass spectrometry-based assays should remain below the 95th centile measured at 9.3 pg/mL for E2 and 0.26 ng/mL for testo in normal postmenopausal women in order to avoid the risk of non-physiological systemic exposure to elevated serum concentrations of these two sex steroids. Estradiol 35-44 cystatin 12, pseudogene Homo sapiens 181-189 28761337-8 2017 The extents of LAA, E2, E3, and E4 were found to be significantly correlated with the PFT parameters (r=-0.53, -0.43, -0.48, and -0.25), with forced expiratory volume in 1 second (FEV1; -0.81, -0.62, -0.75, and -0.40), and with diffusing capacity of the lungs for carbon monoxide (cDLco), respectively. Carbon Monoxide 264-279 cystatin 12, pseudogene Homo sapiens 20-34 28761337-8 2017 The extents of LAA, E2, E3, and E4 were found to be significantly correlated with the PFT parameters (r=-0.53, -0.43, -0.48, and -0.25), with forced expiratory volume in 1 second (FEV1; -0.81, -0.62, -0.75, and -0.40), and with diffusing capacity of the lungs for carbon monoxide (cDLco), respectively. cdlco 281-286 cystatin 12, pseudogene Homo sapiens 20-34 27757837-9 2017 Our results show that the overexpressed ERbeta not only attenuated the effects of fenofibrate to induce the levels of apoptosis protein such as Cyt.c, Caspase 9 and Caspase 3 but also inhibited the levels of survival protein such Bcl-xL, p-Bad, cyclin A and cyclin E. All these effects of E2/ERbeta resulted in the enhancement of mitochondria dependent apoptotic pathway and the attenuation of cell proliferation. Fenofibrate 82-93 cystatin 12, pseudogene Homo sapiens 289-298 27757837-12 2017 The E2/ERbeta further inhibited the fenofibrate-induced nuclear translocation of PPARalpha. Fenofibrate 36-47 cystatin 12, pseudogene Homo sapiens 4-13 28504268-4 2017 In high external magnetic fields, we observe a universal Faraday rotation angle equal to the fine structure constant alpha=e2/2hc (in SI units) when a linearly polarized THz radiation of a certain frequency passes through the two surfaces of a strained HgTe 3D TI. thz 170-173 cystatin 12, pseudogene Homo sapiens 117-125 27250495-1 2017 This study aimed at evaluation of a relationship between blood selenium concentration (Se-B) and blood cystatin C concentration (CST) in a randomly selected population of healthy children, environmentally exposed to lead and cadmium. Selenium 63-71 cystatin 12, pseudogene Homo sapiens 129-132 28618990-1 2017 BACKGROUND: Research on Chromogranin A (CGA) and its derived fragments convincingly demonstrated the multifunctional activity of the 21 amino acid peptide named Catestatin (CST: human CGA352-372, bovine CGA344-364, rat CGA367-387). amino acid peptide 136-154 cystatin 12, pseudogene Homo sapiens 173-176 28618990-4 2017 RESULTS: CST is mainly known as an inhibitor of the nicotinic-dependent Catecholamine (CA) release, and an anti-hypertensive peptide, but its role includes a modulation of antioxidant and immune defense, epidermal function, and adipose tissue homeostasis. Catecholamines 72-85 cystatin 12, pseudogene Homo sapiens 9-12 27345158-6 2016 CONCLUSIONS: Low-dose E2/NETA showed a significantly higher increase in BMD compared to tibolone. tibolone 88-96 cystatin 12, pseudogene Homo sapiens 22-29 25797375-10 2015 Administration of estradienedione resulted in an increase of E2 and S-1 in an increase of cortisol. estradienedione 18-33 cystatin 12, pseudogene Homo sapiens 61-71 27312786-4 2016 Here, the effect of the E2/ERalpha-dependent upregulation of neuroglobin (NGB), an antiapoptotic globin, on the reduced sensitivity of breast cancer cells to paclitaxel-induced apoptosis has been evaluated in ERalpha-containing MCF-7 cells. Paclitaxel 158-168 cystatin 12, pseudogene Homo sapiens 24-34 27312786-6 2016 NGB displays a pivotal role in the E2/ERalpha-induced antiapoptotic pathway to abrogate paclitaxel-induced cell death in stable NGB-silenced MCF-7 cell clones. Paclitaxel 88-98 cystatin 12, pseudogene Homo sapiens 35-45 27271044-4 2016 Stimulation of HBE or 16HBE14o- cells with E2 or G1, a specific agonist of GPER, attenuated the nucleotide-evoked increases in [Ca(2+)]i, whereas this effect was reversed by G15, a GPER-specific antagonist. 16hbe14o 22-30 cystatin 12, pseudogene Homo sapiens 43-51 27322147-1 2016 Prostaglandin E-2 (PGE-2) promotes tumor angiogenesis via paracrine secretion of pro-angiogenic growth factors, such as vascular endothelial growth factor (VEGF). Dinoprostone 19-24 cystatin 12, pseudogene Homo sapiens 14-17 27847626-10 2016 Pearson"s correlation analysis revealed a positive correlation of TBARS with CST (r = 0.29; p = 0.038) and CAT (r = 0.31; p = 0.04). Thiobarbituric Acid Reactive Substances 66-71 cystatin 12, pseudogene Homo sapiens 77-80 27847626-12 2016 On univariate analysis with logMAR visual acuity as dependent variable, a significant increase in visual acuity was observed with increase in independent variables TBARS (B = 0.22; p = 0.004), NO (B = 0.006; p < 0.001), CST (B = 0.005; p < 0.001) and CAT (B = 0.005; p < 0.001). Thiobarbituric Acid Reactive Substances 164-169 cystatin 12, pseudogene Homo sapiens 223-226 27847626-13 2016 On multivariate linear regression analysis with logMAR visual acuity as dependent variable and adjusting for other factors like duration of diabetes and HbA1c, it was observed that increase in independent variables TBARS (B = 0.07), NO (B = 0.001) and CST (B = 0.004) independently predict increase in logMAR visual acuity (p < 0.001). Thiobarbituric Acid Reactive Substances 215-220 cystatin 12, pseudogene Homo sapiens 252-255 25786660-2 2015 Comparative studies on structural analogs (E2, E3, and E4) provided significant insight into the structural and functional role of the amide N-H and IHB segment in the selective recognition of fluoride ions. Amides 135-140 cystatin 12, pseudogene Homo sapiens 43-57 25786660-2 2015 Comparative studies on structural analogs (E2, E3, and E4) provided significant insight into the structural and functional role of the amide N-H and IHB segment in the selective recognition of fluoride ions. Fluorides 193-201 cystatin 12, pseudogene Homo sapiens 43-57 26204554-2 2015 All of these processes can be modulated by cyclic adenosine monophosphate-elevating prostaglandins E2 and I2 (also known as prostacyclin). Cyclic AMP 43-73 cystatin 12, pseudogene Homo sapiens 99-108 26204554-2 2015 All of these processes can be modulated by cyclic adenosine monophosphate-elevating prostaglandins E2 and I2 (also known as prostacyclin). Epoprostenol 124-136 cystatin 12, pseudogene Homo sapiens 99-108 26379944-6 2015 Thus, we conclude that high E2/oocyte ratio adversely affects live birth rate in women undergoing IVF treated with GnRH-a long protocol. gnrh-a 115-121 cystatin 12, pseudogene Homo sapiens 28-37 27016131-6 2016 In addition, E2 and G1 stimulated intracellular calcium modulation and phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 within seconds and minutes in CAFs, respectively. Calcium 48-55 cystatin 12, pseudogene Homo sapiens 13-22 27559381-1 2016 (Aminoferrocenyl)(ferrocenyl)carbene(pentacarbonyl)tungsten(0) (CO)5W=C(NHFc)Fc (W(CO) 5 ( E -2)) is synthesized by nucleophilic substitution of the ethoxy group of (CO)5W=C(OEt)Fc (M(CO) 5 (1 (Et) )) by ferrocenyl amide Fc-NH(-) (Fc = ferrocenyl). ferrocenyl)carbene(pentacarbonyl)tungsten 18-59 cystatin 12, pseudogene Homo sapiens 91-95 27559381-1 2016 (Aminoferrocenyl)(ferrocenyl)carbene(pentacarbonyl)tungsten(0) (CO)5W=C(NHFc)Fc (W(CO) 5 ( E -2)) is synthesized by nucleophilic substitution of the ethoxy group of (CO)5W=C(OEt)Fc (M(CO) 5 (1 (Et) )) by ferrocenyl amide Fc-NH(-) (Fc = ferrocenyl). ferrocenyl 6-16 cystatin 12, pseudogene Homo sapiens 91-95 27559381-2 2016 W(CO) 5 ( E -2) thermally and photochemically eliminates bulky E-1,2-diferrocenylimine ( E -3) via a formal 1,2-H shift from the N to the carbene C atom. co) 2-5 cystatin 12, pseudogene Homo sapiens 10-14 27559381-2 2016 W(CO) 5 ( E -2) thermally and photochemically eliminates bulky E-1,2-diferrocenylimine ( E -3) via a formal 1,2-H shift from the N to the carbene C atom. e-1,2-diferrocenylimine 63-86 cystatin 12, pseudogene Homo sapiens 10-14 27559381-2 2016 W(CO) 5 ( E -2) thermally and photochemically eliminates bulky E-1,2-diferrocenylimine ( E -3) via a formal 1,2-H shift from the N to the carbene C atom. carbene 138-145 cystatin 12, pseudogene Homo sapiens 10-14 25968070-4 2015 Prx1 and Prx6 are multifunctional proteins important for cell protection against oxidative stress, but also work together to facilitate production of prostaglandins E2 and D2 (PGE2 and PGD2). Dinoprostone 176-180 cystatin 12, pseudogene Homo sapiens 165-174 25744245-7 2015 Additionally, in vitro administration of E2 and G1 increased the number of tumor nodules, tumor grade, and tumor index in a urethane-induced adenocarcinoma model. Urethane 124-132 cystatin 12, pseudogene Homo sapiens 41-50 24908069-5 2015 Endometrial stromal cells (ESCs) and endometrial glandular cells (EGCs) within the endometrium show morphological changes when exposed to E2 and P4. egcs 66-70 cystatin 12, pseudogene Homo sapiens 138-147 25747128-10 2015 CONCLUSION(S): Our results demonstrate that PFOS and perfluorooctanesulfonic acid may be associated with decreased production of E2 and P in reproductive age women. perfluorooctane sulfonic acid 44-48 cystatin 12, pseudogene Homo sapiens 129-137 25747128-10 2015 CONCLUSION(S): Our results demonstrate that PFOS and perfluorooctanesulfonic acid may be associated with decreased production of E2 and P in reproductive age women. perfluorooctane sulfonic acid 53-81 cystatin 12, pseudogene Homo sapiens 129-137 25675114-2 2015 We have previously shown that estrogen 17beta-estradiol (E2) transrepresses bile salt export pump (BSEP) through an interaction between estrogen receptor (ER)-alpha and farnesoid X receptor (FXR) and transrepression of BSEP by E2/ERalpha is an etiological contributing factor to intrahepatic cholestasis of pregnancy. Estradiol 39-55 cystatin 12, pseudogene Homo sapiens 227-237 25675114-2 2015 We have previously shown that estrogen 17beta-estradiol (E2) transrepresses bile salt export pump (BSEP) through an interaction between estrogen receptor (ER)-alpha and farnesoid X receptor (FXR) and transrepression of BSEP by E2/ERalpha is an etiological contributing factor to intrahepatic cholestasis of pregnancy. Bile Acids and Salts 76-85 cystatin 12, pseudogene Homo sapiens 227-237 25651915-7 2015 SSeo also reduced TNF-alpha-induced production of pro-inflammatory mediators such as nitric oxide and prostaglandin E2 and inhibited inducible nitric oxide synthase and cyclooxygenase-2 expression in HASMCs. sseo 0-4 cystatin 12, pseudogene Homo sapiens 116-164 26007631-10 2015 E2/NOMAC showed statistically significantly favourable results on haemostatic markers and had a neutral effect on carbohydrate and lipid metabolism when compared with EE/LNG. Carbohydrates 114-126 cystatin 12, pseudogene Homo sapiens 0-8 24481325-7 2014 Furthermore, TAM, E2, and G1 promoted CAF proliferation and cell-cycle progression, both of which were blocked by GPER interference, the selective GPER antagonist G15, the epidermal growth factor receptor (EGFR) inhibitor AG1478, and the ERK1/2 inhibitor U0126. U 0126 255-260 cystatin 12, pseudogene Homo sapiens 18-28 25632479-2 2014 The three dihydrostilbenes (PA-82, GA-23, DO-07) were in vitro tested to evaluate their capability to scavenge the stable radical 1,1-diphenyl-2-picrylhydrazyl (DPPH), and to decrease thromboxane B2 (TxB2) and prostaglandin E2 (PGE2) release in human whole blood samples. 1,2-dihydrostilbene 10-26 cystatin 12, pseudogene Homo sapiens 224-241 24694340-7 2014 The associations between E2 and free E2 and cortical porosity remained significant after further adjustment for height, weight, physical activity, calcium intake, and smoking. Calcium 147-154 cystatin 12, pseudogene Homo sapiens 25-39 24816529-13 2014 Both E2 and GH replacements reduced hepatic CHO levels and increased the formation of cholesterol esters and triacylglycerols. Cholesterol Esters 86-104 cystatin 12, pseudogene Homo sapiens 5-14 24816529-13 2014 Both E2 and GH replacements reduced hepatic CHO levels and increased the formation of cholesterol esters and triacylglycerols. Triglycerides 109-125 cystatin 12, pseudogene Homo sapiens 5-14 24338848-2 2014 These modifiers are reversibly attached via an isopeptide bond to lysine side chains of their target proteins by the action of specific E1, E2, and E3 enzymes. Lysine 66-72 cystatin 12, pseudogene Homo sapiens 140-150 24440569-6 2014 E2 and ICI also induced phosphorylation of extracellular regulated protein kinases 1 and 2 (ERK1/2), and suppression of ERK1/2 phosphorylation by U0126 profoundly impeded calpain activation triggered by estrogenic and antiestrogenic stimulations indicating implication of ERK1/2 in the GPR30-mediated action. U 0126 146-151 cystatin 12, pseudogene Homo sapiens 0-10 23832170-1 2014 This study aims to compare the effects of low-dose emidrate estradiol/drospirenone (E2/DRSP) vs low-dose emidrate estradiol/dydrogesterone (E2/DG) combination on the mean amplitude of glycemic excursions (MAGE) value in postmenopausal women affected by metabolic syndrome (MS). drospirenone 70-82 cystatin 12, pseudogene Homo sapiens 84-91 23832170-1 2014 This study aims to compare the effects of low-dose emidrate estradiol/drospirenone (E2/DRSP) vs low-dose emidrate estradiol/dydrogesterone (E2/DG) combination on the mean amplitude of glycemic excursions (MAGE) value in postmenopausal women affected by metabolic syndrome (MS). Dydrogesterone 124-138 cystatin 12, pseudogene Homo sapiens 140-145 23677028-5 2014 Administration of E2 and P4 (0.1mgkg(-1) diluted in 0.1mL of mineral oil, every 48h over 30 days) resulted in a recovery of overall prostate structure, as evidenced by increased epithelial height, mass and prostatic secretory activity, without leading the appearance of significant lesions. Mineral Oil 61-72 cystatin 12, pseudogene Homo sapiens 18-27 24934729-6 2014 E2, E3 and E4 significantly inhibited nitric oxide generation from lipopolysaccharide (LPS)-stimulated spleen macrophages, while E1, E3 and E4 led to significant inhibition of LPS-induced tumour necrosis factor-alpha. Nitric Oxide 38-50 cystatin 12, pseudogene Homo sapiens 0-13 25462070-4 2014 The E2/ER-mediated SOD2 up-regulation results in minimized ROS generation, which highly favors healthy cardiovascular function. ros 59-62 cystatin 12, pseudogene Homo sapiens 4-9 23809501-11 2013 CONCLUSION(S): Early initiation of GnRH-a cotreatment results in a more stable endocrine profile, with more physiological levels of E2 and LH during the follicular phase. gnrh-a 35-41 cystatin 12, pseudogene Homo sapiens 132-141 23859654-5 2013 Airway levels of cys-leukotrienes and leukotriene B4 (LTB4) are both significantly elevated in I5/hE2 mice. cys-leukotrienes 17-33 cystatin 12, pseudogene Homo sapiens 98-101 23859654-5 2013 Airway levels of cys-leukotrienes and leukotriene B4 (LTB4) are both significantly elevated in I5/hE2 mice. Leukotriene B4 38-52 cystatin 12, pseudogene Homo sapiens 98-101 23859654-7 2013 More importantly, the loss of leukotrienes led to an unexpectedly significant decrease in collagen deposition (i.e., pulmonary fibrosis) that accompanied elevated levels of IL-4/-13 and TGF-beta in the lungs of I5/hE2 mice. Leukotrienes 30-42 cystatin 12, pseudogene Homo sapiens 214-217 23954500-2 2013 To document the possibility of achieving this therapeutic objective, we have measured individual 24h serum E2 and testosterone concentrations in women with vulvovaginal atrophy (VVA) receiving daily intravaginal administration of a clinically effective dose of 6.5mg prasterone (dehydroepiandrosterone, DHEA). vva 178-181 cystatin 12, pseudogene Homo sapiens 107-126 23718638-4 2013 Mechanistically, the data obtained from biochemical analyses revealed that (i) Delta(9)-THC up-regulates ERbeta, a repressor of ERalpha, inhibiting the expression of E2/ERalpha-regulated genes that promote cell growth and that (ii) Delta(9)-THC induction of ERbeta modulates E2/ERalpha signaling in the absence of direct interaction with the E2 ligand binding site. Dronabinol 79-91 cystatin 12, pseudogene Homo sapiens 166-176 23718638-5 2013 Therefore, the data presented support the concept that Delta(9)-THC"s antiestrogenic activities are mediated by the ERbeta disruption of E2/ERalpha signaling. delta(9) 55-63 cystatin 12, pseudogene Homo sapiens 137-147 23718638-5 2013 Therefore, the data presented support the concept that Delta(9)-THC"s antiestrogenic activities are mediated by the ERbeta disruption of E2/ERalpha signaling. Dronabinol 64-67 cystatin 12, pseudogene Homo sapiens 137-147 23762435-5 2013 Incubation of estrogens with lactoperoxidase (LPO) and H2O2 resulted in formation of respective quinone methides (E1(E2)-QM). Hydrogen Peroxide 55-59 cystatin 12, pseudogene Homo sapiens 114-119 26583858-10 2013 Although the principal relations between the EDD and CST for hydrogen bonding (HB) and stacking interactions are similar, the real-space consequences are rather different. Hydrogen 61-69 cystatin 12, pseudogene Homo sapiens 53-56 23762435-5 2013 Incubation of estrogens with lactoperoxidase (LPO) and H2O2 resulted in formation of respective quinone methides (E1(E2)-QM). quinone 96-103 cystatin 12, pseudogene Homo sapiens 114-119 23762435-6 2013 Subsequent addition of adenine to the assay mixture lead to trapping of E1(E2)-QM, resulting in formation of adenine adducts of estrogens, E1(E2)-9-N-Ade. Adenine 23-30 cystatin 12, pseudogene Homo sapiens 72-77 23762435-6 2013 Subsequent addition of adenine to the assay mixture lead to trapping of E1(E2)-QM, resulting in formation of adenine adducts of estrogens, E1(E2)-9-N-Ade. Adenine 23-30 cystatin 12, pseudogene Homo sapiens 139-147 23762435-6 2013 Subsequent addition of adenine to the assay mixture lead to trapping of E1(E2)-QM, resulting in formation of adenine adducts of estrogens, E1(E2)-9-N-Ade. Adenine 109-116 cystatin 12, pseudogene Homo sapiens 72-77 23762435-6 2013 Subsequent addition of adenine to the assay mixture lead to trapping of E1(E2)-QM, resulting in formation of adenine adducts of estrogens, E1(E2)-9-N-Ade. Adenine 109-116 cystatin 12, pseudogene Homo sapiens 139-147 23762435-7 2013 Targeted ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) based metabolomic analysis of the breast tissue extracts showed the presence of adenine adducts of estrogens, E1(E2)-9-N-Ade, along with other estrogen related metabolites. Adenine 167-174 cystatin 12, pseudogene Homo sapiens 197-205 23762435-7 2013 Targeted ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) based metabolomic analysis of the breast tissue extracts showed the presence of adenine adducts of estrogens, E1(E2)-9-N-Ade, along with other estrogen related metabolites. Nitrogen 206-207 cystatin 12, pseudogene Homo sapiens 197-205 23762435-7 2013 Targeted ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) based metabolomic analysis of the breast tissue extracts showed the presence of adenine adducts of estrogens, E1(E2)-9-N-Ade, along with other estrogen related metabolites. Adenine 208-211 cystatin 12, pseudogene Homo sapiens 197-205 23441755-0 2013 Low prostaglandin E2 and cyclooxygenase expression in nasal mucosa fibroblasts of aspirin-intolerant asthmatics. Aspirin 82-89 cystatin 12, pseudogene Homo sapiens 18-39 23507363-4 2013 When mag-MFMIP beads were used as dispersed solid-phase extraction (SPE) adsorbents in water samples, the recoveries of estriol (E3), bisphenol A (BPA), E2 and ethynylestradiol (EE) were 72.2 - 92.1%, 89.3 - 96.0%, 93.3 - 102% and 89.7 - 95.9%, respectively with relative standard deviation (RSD) lower than 7.0%. mag-mfmip 5-14 cystatin 12, pseudogene Homo sapiens 153-176 23615640-13 2013 A decrease in cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol was induced by E2/NA but not by E2. Cholesterol 14-25 cystatin 12, pseudogene Homo sapiens 120-125 22377968-2 2012 However, it is unknown if 17beta-estradiol (E(2)) treatment is sufficient to inhibit cell proliferation and cell migration in human colon cancer cells. Estradiol 26-42 cystatin 12, pseudogene Homo sapiens 44-48 22913669-7 2013 Indoleamine 2,3-dioxygenase (IDO) and prostaglandin E-2 (PGE) were identified as key mechanisms of action involved in the mesoangioblast suppression of T-cell proliferation. Dinoprostone 57-60 cystatin 12, pseudogene Homo sapiens 52-55 23448447-4 2013 Among them, CYP1B1 predominantly catalyzes the C4-position of E2 and forms carcinogenic 4-hydroxy-E2 (4-OHE2), whereas CYP1A1 and CYP1A2 convert E2 to noncarcinogenic 2-hydroxy-E2. 4-ohe2 102-108 cystatin 12, pseudogene Homo sapiens 62-100 23128637-3 2013 Without polymer addition, the CST was 160 s for a BR of 0.75 compared with 355 s for the biosolids alone. Polymers 8-15 cystatin 12, pseudogene Homo sapiens 30-33 23128637-4 2013 The optimum polymer dose (OPD), defined as the polymer dose yielding CST of 20 s, was reduced from 20.6 g kg(-1) dry solids for the biosolids alone to 16.3 and 12.6 g kg(-1) when BR was 0.75 and 1.5, respectively. Polymers 12-19 cystatin 12, pseudogene Homo sapiens 69-72 23448447-4 2013 Among them, CYP1B1 predominantly catalyzes the C4-position of E2 and forms carcinogenic 4-hydroxy-E2 (4-OHE2), whereas CYP1A1 and CYP1A2 convert E2 to noncarcinogenic 2-hydroxy-E2. 2-hydroxy-e2 167-179 cystatin 12, pseudogene Homo sapiens 62-100 23074235-11 2012 The estrogen antagonist, hydroxytamoxifen, the active metabolite of tamoxifen, reduced IGF1R protein levels and both E2- and IGF-II-induced cell proliferation. hydroxytamoxifen 25-41 cystatin 12, pseudogene Homo sapiens 117-131 23074235-11 2012 The estrogen antagonist, hydroxytamoxifen, the active metabolite of tamoxifen, reduced IGF1R protein levels and both E2- and IGF-II-induced cell proliferation. Tamoxifen 32-41 cystatin 12, pseudogene Homo sapiens 117-131 24052849-0 2012 Facile Iodine-Catalyzed Michael Addition of Indoles to alpha,alpha"-Bis(arylmethylene)cyclopentanones: An Efficient Synthesis of E-2-(3-Indolylphenylmethyl)-5-phenylmethylenecyclopentanones. Iodine 7-13 cystatin 12, pseudogene Homo sapiens 129-132 24052849-0 2012 Facile Iodine-Catalyzed Michael Addition of Indoles to alpha,alpha"-Bis(arylmethylene)cyclopentanones: An Efficient Synthesis of E-2-(3-Indolylphenylmethyl)-5-phenylmethylenecyclopentanones. Indoles 44-51 cystatin 12, pseudogene Homo sapiens 129-132 24052849-0 2012 Facile Iodine-Catalyzed Michael Addition of Indoles to alpha,alpha"-Bis(arylmethylene)cyclopentanones: An Efficient Synthesis of E-2-(3-Indolylphenylmethyl)-5-phenylmethylenecyclopentanones. alpha,alpha"-bis(arylmethylene)cyclopentanones 55-101 cystatin 12, pseudogene Homo sapiens 129-132 24052849-1 2012 Iodine-catalyzed reaction of indoles with alpha,alpha"-bis(arylmethylene)cyclopentanones afforded one diastereomer of the corresponding Michael adducts, namely, E-2-(3-indolylphenylmethyl)-5-phenylmethylenecyclopentanones, in a good yield. Iodine 0-6 cystatin 12, pseudogene Homo sapiens 161-164 24052849-1 2012 Iodine-catalyzed reaction of indoles with alpha,alpha"-bis(arylmethylene)cyclopentanones afforded one diastereomer of the corresponding Michael adducts, namely, E-2-(3-indolylphenylmethyl)-5-phenylmethylenecyclopentanones, in a good yield. Indoles 29-36 cystatin 12, pseudogene Homo sapiens 161-164 24052849-1 2012 Iodine-catalyzed reaction of indoles with alpha,alpha"-bis(arylmethylene)cyclopentanones afforded one diastereomer of the corresponding Michael adducts, namely, E-2-(3-indolylphenylmethyl)-5-phenylmethylenecyclopentanones, in a good yield. alpha,alpha"-bis(arylmethylene)cyclopentanones 42-88 cystatin 12, pseudogene Homo sapiens 161-164 22571223-8 2012 Acute testosterone (TEST) and estradiol/testosterone (E2/TEST) ratios were associated with PHH and outcome. Testosterone 40-52 cystatin 12, pseudogene Homo sapiens 54-61 22445438-10 2012 Erythromycin coadministration also resulted in increased mean C(max) and AUC(0-24 h) of both E2 and DNG. Erythromycin 0-12 cystatin 12, pseudogene Homo sapiens 93-103 22657566-6 2012 A significant positive correlation was found between ghrelin and each of E2 and BMD (at one or more of the three sites assessed) in all subjects, as well as, in peri- and postmenopausal women, whereas a significant negative correlation was found between ghrelin and FSH. Ghrelin 53-60 cystatin 12, pseudogene Homo sapiens 73-83 22357947-8 2012 Consistently, CST peptides blocked various stages of nAChR signal transduction, such as nicotine- or acetylcholine-evoked inward current, rise in intracellular Ca(2+) and catecholamine secretion in or from neuron-differentiated PC12 cells, in the same rank order. Nicotine 88-96 cystatin 12, pseudogene Homo sapiens 14-17 22357947-8 2012 Consistently, CST peptides blocked various stages of nAChR signal transduction, such as nicotine- or acetylcholine-evoked inward current, rise in intracellular Ca(2+) and catecholamine secretion in or from neuron-differentiated PC12 cells, in the same rank order. Acetylcholine 101-114 cystatin 12, pseudogene Homo sapiens 14-17 22357947-8 2012 Consistently, CST peptides blocked various stages of nAChR signal transduction, such as nicotine- or acetylcholine-evoked inward current, rise in intracellular Ca(2+) and catecholamine secretion in or from neuron-differentiated PC12 cells, in the same rank order. Catecholamines 171-184 cystatin 12, pseudogene Homo sapiens 14-17 22121121-7 2012 In low moisture content aprotic solvents, vitamin K (a quinone) is reduced in two one-electron chemically reversible steps to form first a radical anion (semiquinone, at E(1)) and then at more negative potentials a dianion is formed (at E(2)). Vitamin K 42-51 cystatin 12, pseudogene Homo sapiens 237-241 22121121-7 2012 In low moisture content aprotic solvents, vitamin K (a quinone) is reduced in two one-electron chemically reversible steps to form first a radical anion (semiquinone, at E(1)) and then at more negative potentials a dianion is formed (at E(2)). quinone 55-62 cystatin 12, pseudogene Homo sapiens 237-241 22121121-8 2012 The dianion is especially prone to strong hydrogen-bonding interactions with trace water present in the organic solvents, resulting in a shift in the formal reduction potential of E(2) to more positive potentials as more water is added to the solvent. Hydrogen 42-50 cystatin 12, pseudogene Homo sapiens 180-184 22121121-8 2012 The dianion is especially prone to strong hydrogen-bonding interactions with trace water present in the organic solvents, resulting in a shift in the formal reduction potential of E(2) to more positive potentials as more water is added to the solvent. Water 83-88 cystatin 12, pseudogene Homo sapiens 180-184 22121121-8 2012 The dianion is especially prone to strong hydrogen-bonding interactions with trace water present in the organic solvents, resulting in a shift in the formal reduction potential of E(2) to more positive potentials as more water is added to the solvent. Water 221-226 cystatin 12, pseudogene Homo sapiens 180-184 22058158-2 2012 We have shown that CST directly influences the basal performance of the vertebrate heart where CST dose dependently induced a nitric oxide-cGMP-dependent cardiosuppression and counteracted the effects of adrenergic stimulation through a noncompetitive antagonism. Nitric Oxide 126-138 cystatin 12, pseudogene Homo sapiens 19-22 22058158-2 2012 We have shown that CST directly influences the basal performance of the vertebrate heart where CST dose dependently induced a nitric oxide-cGMP-dependent cardiosuppression and counteracted the effects of adrenergic stimulation through a noncompetitive antagonism. Nitric Oxide 126-138 cystatin 12, pseudogene Homo sapiens 95-98 22058158-2 2012 We have shown that CST directly influences the basal performance of the vertebrate heart where CST dose dependently induced a nitric oxide-cGMP-dependent cardiosuppression and counteracted the effects of adrenergic stimulation through a noncompetitive antagonism. Cyclic GMP 139-143 cystatin 12, pseudogene Homo sapiens 19-22 22058158-2 2012 We have shown that CST directly influences the basal performance of the vertebrate heart where CST dose dependently induced a nitric oxide-cGMP-dependent cardiosuppression and counteracted the effects of adrenergic stimulation through a noncompetitive antagonism. Cyclic GMP 139-143 cystatin 12, pseudogene Homo sapiens 95-98 22058158-9 2012 In ventricular extracts, CST increased S-nitrosylation of both phospholamban and beta-arrestin, suggesting an additional mechanism for intracellular calcium modulation and beta-adrenergic responsiveness. Calcium 149-156 cystatin 12, pseudogene Homo sapiens 25-28 22058158-11 2012 Our results are of importance in relation to the putative application of CST as a cardioprotective agent against stress, including excessive sympathochromaffin overactivation. sympathochromaffin 141-159 cystatin 12, pseudogene Homo sapiens 73-76 22492571-5 2012 DTTs for the CST were classified into 3 types: type A, the CST was preserved around the hematoma; type B, the CST was interrupted around the hematoma; and type C, the CST did not reach the hematoma. Dithiothreitol 0-4 cystatin 12, pseudogene Homo sapiens 13-16 22492571-5 2012 DTTs for the CST were classified into 3 types: type A, the CST was preserved around the hematoma; type B, the CST was interrupted around the hematoma; and type C, the CST did not reach the hematoma. Dithiothreitol 0-4 cystatin 12, pseudogene Homo sapiens 59-62 22492571-5 2012 DTTs for the CST were classified into 3 types: type A, the CST was preserved around the hematoma; type B, the CST was interrupted around the hematoma; and type C, the CST did not reach the hematoma. Dithiothreitol 0-4 cystatin 12, pseudogene Homo sapiens 59-62 22492571-5 2012 DTTs for the CST were classified into 3 types: type A, the CST was preserved around the hematoma; type B, the CST was interrupted around the hematoma; and type C, the CST did not reach the hematoma. Dithiothreitol 0-4 cystatin 12, pseudogene Homo sapiens 59-62 22285433-4 2012 As these catechol metabolites are believed to mediate the carcinogenicity of E2 and E1 by causing oxidative DNA damage and DNA adducts, their methylation by catechol-O-methyltransferase (COMT) is an important inactivation pathway. catechol 9-17 cystatin 12, pseudogene Homo sapiens 77-86 22285433-6 2012 The microsomal extracts and the individual catechols of alpha-ZAL, ZAN, E2 and E1 were found to induce oxidative DNA damage, as measured by the formation of 8-oxo-7,8-dihydro-2"-deoxyguanosine in a cell-free system. Catechols 43-52 cystatin 12, pseudogene Homo sapiens 72-81 22285433-6 2012 The microsomal extracts and the individual catechols of alpha-ZAL, ZAN, E2 and E1 were found to induce oxidative DNA damage, as measured by the formation of 8-oxo-7,8-dihydro-2"-deoxyguanosine in a cell-free system. 8-ohdg 157-192 cystatin 12, pseudogene Homo sapiens 72-81 22285433-9 2012 Thus, some catechol metabolites of alpha-ZAL and ZAN are better pro-oxidants and poorer substrates of COMT than the catechols of E2 and E1. catechol 11-19 cystatin 12, pseudogene Homo sapiens 129-138 22285433-9 2012 Thus, some catechol metabolites of alpha-ZAL and ZAN are better pro-oxidants and poorer substrates of COMT than the catechols of E2 and E1. Catechols 116-125 cystatin 12, pseudogene Homo sapiens 129-138 22178669-9 2012 In contrast, it was confirmed that the binding of monomeric vanadate (H(2)VO(4)(2-); V(1)) to the calcium pump is favoured only for the E2 and E2P conformations of the ATPase, whereas no significant amount of vanadate is bound to the E1 and E1P conformations. Vanadates 60-68 cystatin 12, pseudogene Homo sapiens 136-146 22178669-9 2012 In contrast, it was confirmed that the binding of monomeric vanadate (H(2)VO(4)(2-); V(1)) to the calcium pump is favoured only for the E2 and E2P conformations of the ATPase, whereas no significant amount of vanadate is bound to the E1 and E1P conformations. Calcium 98-105 cystatin 12, pseudogene Homo sapiens 136-146 22574217-5 2012 Seventy-one genes (42 downregulated and 29 upregulated) were identified as significantly differentially expressed in response to BPA, among which 43 genes were found to be affected exclusively by BPA compared with E2 and TCDD. bisphenol A 129-132 cystatin 12, pseudogene Homo sapiens 214-225 22837658-5 2012 Not previously described, the presence of CD4+ T(Reg) in CSF was higher in women than in men, which could account for the sexual dimorphism in the incidence of MS. A direct correlation between plasma oestradiol (E2) and IL-2 levels was observed, in line with a putative circuit of E2 and perforin expression by CD4+ T(Reg) playing a role in MS. Also, serum IFN-alpha was higher in females, with direct correlation with serum E2 levels. Estradiol 200-210 cystatin 12, pseudogene Homo sapiens 281-296 22016410-6 2011 DT tractography was used to asses the integrity of the CST, corpus callosum, and the major long-range association tracts. Thymidine 0-2 cystatin 12, pseudogene Homo sapiens 55-58 21903908-2 2011 Using DTT with FSL tools, we conducted an investigation of the anatomic location and somatotopic arrangement of the CST at the CP in the human brain. Dithiothreitol 6-9 cystatin 12, pseudogene Homo sapiens 116-119 22066891-10 2011 CONCLUSIONS: The monophasic COC NOMAC/E2 had less influence on haemostasis, lipids and carbohydrate metabolism than the COC LNG/EE. Carbohydrates 87-99 cystatin 12, pseudogene Homo sapiens 32-40 22109378-11 2011 There was a negative correlation between the scores of SDS, HAMD and the level of E2 and T in the erosion group. Sodium Dodecyl Sulfate 55-58 cystatin 12, pseudogene Homo sapiens 82-90 21469181-4 2011 Physiologic premenopausal concentrations of 17beta-estradiol (E(2)) significantly decelerated telomere attrition in MSCs and chondrocytes while postmenopausal E(2) concentration had no significant effects. Estradiol 44-60 cystatin 12, pseudogene Homo sapiens 62-66 21469181-5 2011 The estrogen agonist-antagonist tamoxifen did not affect telomere biology, but inhibited the E(2) -stimulated reduction in telomere shortening. Tamoxifen 32-41 cystatin 12, pseudogene Homo sapiens 93-97 21556420-1 2011 Iron(II) complexes of Z- and E-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine (Z-2 and E-2, respectively) exhibited visible light photoisomerization from Z-2 to E-2, both in solution and in solid phases. Iron 0-4 cystatin 12, pseudogene Homo sapiens 29-32 21820977-3 2011 The synthesized magnetic molecularly imprinted polymers for E2 (E2-MMIPs) showed quick separation, large adsorption capacity, high selectivity and fast binding kinetics for E2. Polymers 47-55 cystatin 12, pseudogene Homo sapiens 64-72 21820977-3 2011 The synthesized magnetic molecularly imprinted polymers for E2 (E2-MMIPs) showed quick separation, large adsorption capacity, high selectivity and fast binding kinetics for E2. Polymers 47-55 cystatin 12, pseudogene Homo sapiens 60-62 21521748-9 2011 Concentration-response studies on female islets from healthy controls and type 2 diabetic subjects showed that both E2 and G-1 displayed important antidiabetic actions by improving glucose-stimulated insulin release while suppressing glucagon and somatostatin secretion. Glucose 181-188 cystatin 12, pseudogene Homo sapiens 116-126 21521748-9 2011 Concentration-response studies on female islets from healthy controls and type 2 diabetic subjects showed that both E2 and G-1 displayed important antidiabetic actions by improving glucose-stimulated insulin release while suppressing glucagon and somatostatin secretion. Glucagon 234-242 cystatin 12, pseudogene Homo sapiens 116-126 21556420-1 2011 Iron(II) complexes of Z- and E-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine (Z-2 and E-2, respectively) exhibited visible light photoisomerization from Z-2 to E-2, both in solution and in solid phases. Iron 0-4 cystatin 12, pseudogene Homo sapiens 81-84 21556420-1 2011 Iron(II) complexes of Z- and E-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine (Z-2 and E-2, respectively) exhibited visible light photoisomerization from Z-2 to E-2, both in solution and in solid phases. Iron 0-4 cystatin 12, pseudogene Homo sapiens 81-84 21073189-3 2011 Under appropriate deposition conditions, Ag nanowires grow from E2 and cross over to E1, forming a E1/(molecule or polymer)/Ag nanowire (NW)/E2 junction. Polymers 115-122 cystatin 12, pseudogene Homo sapiens 64-87 21421664-0 2011 Comparison of a 24-day and a 21-day pill regimen for the novel combined oral contraceptive, nomegestrol acetate and 17beta-estradiol (NOMAC/E2): a double-blind, randomized study. Estradiol 116-132 cystatin 12, pseudogene Homo sapiens 134-142 20739760-15 2010 We have also observed that the frequency of genotype E2/E3 and E2/E4 was significantly higher in patients with normal total serum cholesterol level compared to patients with abnormal cholesterol (P=0.003 OR 2.4 95% CI; 1.3-4.6). Cholesterol 130-141 cystatin 12, pseudogene Homo sapiens 63-68 20965217-1 2010 In 1997, we identified a novel peptide, catestatin (CST: bovine chromogranin A [CHGA]344-364: RSMRLSFRARGYGFRGPGLQL; human CHGA352-372: SSMKLSFRARGYGFRGPGPQL), which is a potent inhibitor of nicotinic-cholinergic-stimulated catecholamine secretion. Catecholamines 224-237 cystatin 12, pseudogene Homo sapiens 52-55 20965217-3 2010 Utilizing systematic polymorphism discovery at the human CHGA locus we discovered three human variants of CST: G364S, P370L, and R374Q that showed differential potencies towards the inhibition of catecholamine secretion. Catecholamines 196-209 cystatin 12, pseudogene Homo sapiens 106-109 20534765-3 2010 OBJECTIVE: We evaluated age and dose-related differences in E2 and DHT levels in response to graded doses of testosterone enanthate in young and older men. testosterone enanthate 109-131 cystatin 12, pseudogene Homo sapiens 60-70 20534765-11 2010 CONCLUSIONS: During im testosterone administration, E2 and DHT levels exhibit saturable increases with dose. Testosterone 23-35 cystatin 12, pseudogene Homo sapiens 52-62 21678670-9 2011 RESULTS: Significantly lesser microleakage score (P < 0.01) and longer resin tag penetration (P < 0.001) observed in EST (mean score 0.5 +/- 0.53) & (12.19 +/- 1.93 microm) when compared to CST (mean score 1.75 +/- 0.89) & (5.96 +/- 1.84 microm) and FT (mean score 1.5 +/- 0.53) & (6.76 +/- 1.82 microm) which showed more microleakage and short resin tags. Adenosine Monophosphate 154-157 cystatin 12, pseudogene Homo sapiens 200-203 20956467-4 2010 METHODS: T47D breast cancer cells were stimulated with 17beta-estradiol (E(2)) or bovine serum albumin (BSA)-E(2) and measured for (18)F-FDG uptake, lactate release, and mitochondrial hexokinase activity. Estradiol 55-71 cystatin 12, pseudogene Homo sapiens 73-77 20956467-13 2010 Immunoblots displayed rapid phosphorylation of PI3K and Akt within minutes of E(2) treatment, and the specific PI3K inhibitors wortmannin and LY294002 abolished the ability of E(2) to elevate (18)F-FDG uptake. Wortmannin 127-137 cystatin 12, pseudogene Homo sapiens 78-82 20956467-13 2010 Immunoblots displayed rapid phosphorylation of PI3K and Akt within minutes of E(2) treatment, and the specific PI3K inhibitors wortmannin and LY294002 abolished the ability of E(2) to elevate (18)F-FDG uptake. Wortmannin 127-137 cystatin 12, pseudogene Homo sapiens 176-180 20956467-13 2010 Immunoblots displayed rapid phosphorylation of PI3K and Akt within minutes of E(2) treatment, and the specific PI3K inhibitors wortmannin and LY294002 abolished the ability of E(2) to elevate (18)F-FDG uptake. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 142-150 cystatin 12, pseudogene Homo sapiens 78-82 20956467-13 2010 Immunoblots displayed rapid phosphorylation of PI3K and Akt within minutes of E(2) treatment, and the specific PI3K inhibitors wortmannin and LY294002 abolished the ability of E(2) to elevate (18)F-FDG uptake. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 142-150 cystatin 12, pseudogene Homo sapiens 176-180 20956467-13 2010 Immunoblots displayed rapid phosphorylation of PI3K and Akt within minutes of E(2) treatment, and the specific PI3K inhibitors wortmannin and LY294002 abolished the ability of E(2) to elevate (18)F-FDG uptake. Fluorine 196-197 cystatin 12, pseudogene Homo sapiens 176-180 20739760-15 2010 We have also observed that the frequency of genotype E2/E3 and E2/E4 was significantly higher in patients with normal total serum cholesterol level compared to patients with abnormal cholesterol (P=0.003 OR 2.4 95% CI; 1.3-4.6). Cholesterol 183-194 cystatin 12, pseudogene Homo sapiens 63-68 20507366-1 2010 AIM: We sought to determine whether triclosan (2,4,4"-trichloro-2"-hydroxydiphenylether), an extensively used anti-plaque agent with broad-spectrum anti-microbial activity, with reported anti-inflammatory effects via inhibition of prostaglandin E2 and interleukin 1 (IL-1)beta, could also more broadly suppress multiple inflammatory gene pathways responsible for the pathogenesis of gingivitis and periodontitis. Triclosan 36-45 cystatin 12, pseudogene Homo sapiens 245-265 20116404-1 2010 In 1997, we identified a novel peptide, catestatin (CST: bovine chromogranin A [CHGA](344-364): RSMRLSFRARGYGFRGPGLQL; human CHGA(352-372): SSMKLSFRARGYGFRGPGPQL), which is a potent inhibitor of nicotinic-cholinergic-stimulated catecholamine secretion. Catecholamines 228-241 cystatin 12, pseudogene Homo sapiens 52-55 20116404-3 2010 Utilizing systematic polymorphism discovery at the human CHGA locus we discovered three human variants of CST: G(364)S, P(370)L, and R(374)Q that showed differential potencies towards the inhibition of catecholamine secretion. Catecholamines 202-215 cystatin 12, pseudogene Homo sapiens 106-109 20371658-3 2010 Whereas this cancer occurs predominantly in postmenopausal women lacking estrogen production by ovaries, the conversion of adrenal androgen-estrogen precursors to estradiol (E(2)), estrone (E(1)), and its sulfate (E(1)-S) has been well documented in peripheral tissues. Estradiol 163-172 cystatin 12, pseudogene Homo sapiens 174-178 20507366-1 2010 AIM: We sought to determine whether triclosan (2,4,4"-trichloro-2"-hydroxydiphenylether), an extensively used anti-plaque agent with broad-spectrum anti-microbial activity, with reported anti-inflammatory effects via inhibition of prostaglandin E2 and interleukin 1 (IL-1)beta, could also more broadly suppress multiple inflammatory gene pathways responsible for the pathogenesis of gingivitis and periodontitis. Triclosan 47-87 cystatin 12, pseudogene Homo sapiens 245-265 19377875-2 2010 Both E2 and PRL resulted in prolonged ERalpha serine-118 phosphorylation, but used different signaling pathways to achieve this end. Serine 46-52 cystatin 12, pseudogene Homo sapiens 5-15 19453300-5 2009 The results established that E2 and TX increased glutamate transporter function and reversed Mn-induced glutamate uptake inhibition, primarily via the up-regulation of glutamate/aspartate transporter (GLAST). Glutamic Acid 49-58 cystatin 12, pseudogene Homo sapiens 29-38 19935720-5 2010 The selective Adora1 antagonist, DPCPX, reduced proliferation, establishing Adora1 as a mediator of E2/ERalpha-dependent breast cancer growth. 1,3-dipropyl-8-cyclopentylxanthine 33-38 cystatin 12, pseudogene Homo sapiens 100-110 19556341-6 2009 These findings show, for the first time, that tyrosine phosphorylation processes play a key role in the rapid changes induced by E2 in aromatase enzymatic activity, revealing the existence of a short nongenomic autocrine loop between E2 and aromatase in breast cancer cells. Tyrosine 46-54 cystatin 12, pseudogene Homo sapiens 234-250 19848195-6 2009 CONCLUSIONS: QXTYR shows favorable effect in depressing blood pressure of menopausal women with hypertension, it can reduce blood pressure variability, improve the symptoms of the menopause syndrome, blood lipid metabolism and plasma levels of Hs-CRP, E2, and Ang II in patients, suggesting that its mechanism may be related to the functional regulation of sympathetic-vagus nerve and neuro-endocrine-immune system, and also the inhibition on the circulatory renin-angiotensin-aldosterone system activity. qxtyr 13-18 cystatin 12, pseudogene Homo sapiens 252-266 19453300-10 2009 Furthermore, the present study is the first to show that both E2 and TX effectively reverse Mn-induced glutamate transport inhibition by restoring its expression and activity, thus offering a potential therapeutic modality in neurodegenerative disorders characterized by altered glutamate homeostasis. Glutamic Acid 103-112 cystatin 12, pseudogene Homo sapiens 62-71 19453300-10 2009 Furthermore, the present study is the first to show that both E2 and TX effectively reverse Mn-induced glutamate transport inhibition by restoring its expression and activity, thus offering a potential therapeutic modality in neurodegenerative disorders characterized by altered glutamate homeostasis. Glutamic Acid 279-288 cystatin 12, pseudogene Homo sapiens 62-71 18256205-9 2008 The estimated K(i) values of vorozole for E2 4- and 2-hydroxylation were 7.26 and 6.84 microM, respectively. vorozole 29-37 cystatin 12, pseudogene Homo sapiens 42-53 19240034-1 2009 The human pyruvate dehydrogenase complex (PDC) is a 9.5-megadalton catalytic machine that employs three catalytic components, i.e. pyruvate dehydrogenase (E1p), dihydrolipoyl transacetylase (E2p), and dihydrolipoamide dehydrogenase (E3), to carry out the oxidative decarboxylation of pyruvate. Pyruvic Acid 10-18 cystatin 12, pseudogene Homo sapiens 191-194 19360821-3 2009 Thus, if one reacts such solutions with transition-metal ions, quaternary M/Sn/E(1)/E(2) anions are obtained, which exhibit coordination by different ternary chalcogenidostannate ligands. Metals 51-56 cystatin 12, pseudogene Homo sapiens 84-88 19360821-3 2009 Thus, if one reacts such solutions with transition-metal ions, quaternary M/Sn/E(1)/E(2) anions are obtained, which exhibit coordination by different ternary chalcogenidostannate ligands. chalcogenidostannate 158-178 cystatin 12, pseudogene Homo sapiens 84-88 19360821-4 2009 The electronic excitation energies of the corresponding alkali metal salts lie between the E(g) values of compounds containing either M/Sn/E(1) or M/Sn/E(2) anions. Metals 63-68 cystatin 12, pseudogene Homo sapiens 152-156 19402404-9 2009 Further investigation suggested that CST was affected by soluble PN, soluble PN/PS, and particle sizes of sludge flocs, but was affected slightly by total PN, PS, or PN/PS in the whole sludge flocs and other fractions (except slime). Polysaccharides 80-82 cystatin 12, pseudogene Homo sapiens 37-40 19402404-9 2009 Further investigation suggested that CST was affected by soluble PN, soluble PN/PS, and particle sizes of sludge flocs, but was affected slightly by total PN, PS, or PN/PS in the whole sludge flocs and other fractions (except slime). Polysaccharides 159-161 cystatin 12, pseudogene Homo sapiens 37-40 19402404-9 2009 Further investigation suggested that CST was affected by soluble PN, soluble PN/PS, and particle sizes of sludge flocs, but was affected slightly by total PN, PS, or PN/PS in the whole sludge flocs and other fractions (except slime). Polysaccharides 159-161 cystatin 12, pseudogene Homo sapiens 37-40 19373615-8 2009 Thus, MCF-7 cells retain their mitogenic and metabolic response to E2 and LB downregulates E2-stimulated growth via the formation of antiproliferative 2-OHE1 and accelerated conversion of mitogenic 16alpha-OHE1 to antimitogenic E3. 2-hydroxyestrone 151-157 cystatin 12, pseudogene Homo sapiens 67-76 19373615-8 2009 Thus, MCF-7 cells retain their mitogenic and metabolic response to E2 and LB downregulates E2-stimulated growth via the formation of antiproliferative 2-OHE1 and accelerated conversion of mitogenic 16alpha-OHE1 to antimitogenic E3. 16-hydroxyestrone 198-210 cystatin 12, pseudogene Homo sapiens 67-76 18806686-3 2008 The aim of the study was to investigate the effects of intranasal E2 with norethisterone (E2/NET) versus oral E2/NET acetate on IGF-I, IGF binding protein 3, and insulin resistance in postmenopausal women. Norethindrone 74-88 cystatin 12, pseudogene Homo sapiens 90-96 18683931-1 2008 Combining information from time-resolved X-ray and neutron scattering with theoretical calculations has revealed the elegant mechanism whereby hydrogen crystalline silicotitanate (H-CST; H2Ti2SiO7 x 1.5 H2O) achieves its remarkable ion-exchange selectivity for cesium. Hydrogen 143-151 cystatin 12, pseudogene Homo sapiens 182-185 18683931-1 2008 Combining information from time-resolved X-ray and neutron scattering with theoretical calculations has revealed the elegant mechanism whereby hydrogen crystalline silicotitanate (H-CST; H2Ti2SiO7 x 1.5 H2O) achieves its remarkable ion-exchange selectivity for cesium. Water 203-206 cystatin 12, pseudogene Homo sapiens 182-185 18683931-1 2008 Combining information from time-resolved X-ray and neutron scattering with theoretical calculations has revealed the elegant mechanism whereby hydrogen crystalline silicotitanate (H-CST; H2Ti2SiO7 x 1.5 H2O) achieves its remarkable ion-exchange selectivity for cesium. Cesium 261-267 cystatin 12, pseudogene Homo sapiens 182-185 18683931-2 2008 Rather than a simple ion-for-ion displacement reaction into favorable sites, which has been suggested by static structural studies of ion-exchanged variants of CST, Cs(+) exchange proceeds via a two-step process mediated by conformational changes in the framework. Cesium 165-170 cystatin 12, pseudogene Homo sapiens 160-163 18683931-4 2008 Here we show that these interactions induce a subtle conformational rearrangement in CST that unlocks the preferred Cs site and increases the overall capacity and selectivity for ion exchange. Cesium 116-118 cystatin 12, pseudogene Homo sapiens 85-88 18486173-11 2008 Both E2 and NIF produced significant relaxation in HSV rings contracted by direct activation of PKC in Krebs" solution. krebs 103-108 cystatin 12, pseudogene Homo sapiens 5-15 18708377-3 2008 This report presents the reproducibility of measurements of androstenedione (A), testosterone (T), estrone (E(1)), and estradiol (E(2)), using breast adipose tissue samples obtained from women undergoing surgical resection for a variety of pathologic conditions. Estradiol 119-128 cystatin 12, pseudogene Homo sapiens 130-134 21468177-2 2009 Ubiquitin (Ub) is covalently attached to the lysine residue of the substrate proteins and activation and attachment of Ub to a target protein is mediated by the action of three enzymes (i.e., E1, E2, and E3). Lysine 45-51 cystatin 12, pseudogene Homo sapiens 196-206 19045417-13 2008 In epsilon(i)(E) spectra of nc-Si we have observed that not only the optical transition E(1) peak reduced but it tends to disappear and to form with E(2) only a single broad peak centered at around 4.3 eV. Silicon 31-33 cystatin 12, pseudogene Homo sapiens 149-153 18544561-5 2008 When MCF-7 cells were exposed to E2 and BPA in combination with the specific kinase inhibitors pyrazolopyrimidine and 2"-amino-3"-methoxyflavone, reductions in micronucleus frequencies occurred. 1H-pyrazolo[4,3-d]pyrimidine 95-113 cystatin 12, pseudogene Homo sapiens 33-43 18544561-5 2008 When MCF-7 cells were exposed to E2 and BPA in combination with the specific kinase inhibitors pyrazolopyrimidine and 2"-amino-3"-methoxyflavone, reductions in micronucleus frequencies occurred. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 118-144 cystatin 12, pseudogene Homo sapiens 33-43 18829517-4 2008 RESULTS: Letrozole suppressed pretreatment tumor levels of E(2), E(1), and E(1)S by 97.6%, 90.7%, and 90.1%, respectively. Letrozole 9-18 cystatin 12, pseudogene Homo sapiens 59-63 18829517-7 2008 Letrozole consistently suppressed each plasma estrogen fraction below the levels recorded for anastrozole: E(2) (average suppression by 95.2% versus 92.8%; P = 0.018), E(1) (98.8% suppression versus 96.3%; P = 0.003), and E(1)S (98.9% suppression versus 95.3%; P = 0.003). Letrozole 0-9 cystatin 12, pseudogene Homo sapiens 107-111 18519947-1 2008 We report that in endothelial cells, the angiogenic effect of 17beta-estradiol (E2) is inhibited by the estrogen receptor (ER) antagonist ICI or the NO synthase (NOS) inhibitor 7-nitroindazole via downregulation of hTERT, the telomerase catalytic subunit, suggesting that E2 and NO are involved in controlling hTERT transcription. Estradiol 62-78 cystatin 12, pseudogene Homo sapiens 272-281 18519947-1 2008 We report that in endothelial cells, the angiogenic effect of 17beta-estradiol (E2) is inhibited by the estrogen receptor (ER) antagonist ICI or the NO synthase (NOS) inhibitor 7-nitroindazole via downregulation of hTERT, the telomerase catalytic subunit, suggesting that E2 and NO are involved in controlling hTERT transcription. Estradiol 80-82 cystatin 12, pseudogene Homo sapiens 272-281 18519947-1 2008 We report that in endothelial cells, the angiogenic effect of 17beta-estradiol (E2) is inhibited by the estrogen receptor (ER) antagonist ICI or the NO synthase (NOS) inhibitor 7-nitroindazole via downregulation of hTERT, the telomerase catalytic subunit, suggesting that E2 and NO are involved in controlling hTERT transcription. 7-nitroindazole 177-192 cystatin 12, pseudogene Homo sapiens 272-281 17599049-5 2007 Insertion of a response element or a relatively strong Sp1 cluster to recruit ER upstream of the core promoters caused a switch to activation by E2/ER that was inhibited by Tam. Tamoxifen 173-176 cystatin 12, pseudogene Homo sapiens 145-150 18375896-12 2008 CONCLUSION: Letrozole reduces plasma E2 and E1S levels to a significantly greater extent than anastrozole in postmenopausal women taking AIs as part of their adjuvant therapy for hormone receptor-positive breast cancer. Letrozole 12-21 cystatin 12, pseudogene Homo sapiens 37-47 18304284-14 2008 The statistically significant higher FSFI scores in the tibolone group, when compared to the E2/NETA group, may be because of tibolone"s combined estrogenic and androgenic properties. tibolone 126-134 cystatin 12, pseudogene Homo sapiens 93-100 18525138-2 2008 Therefore, it seems that combined DTT/fMRI would allow more accurate evaluation of the state of the CST. Dithiothreitol 34-37 cystatin 12, pseudogene Homo sapiens 100-103 17084844-5 2007 RESULTS: Oral E2/NETA reduced ADMA concentrations (-7.4%; 95% confidence interval (CI) -10.4 to -4.4%), while intranasal E2/NET had no effect (-0.8%; 95% CI -3.7 to 2.1%) after 52 weeks. N,N-dimethylarginine 30-34 cystatin 12, pseudogene Homo sapiens 14-21 17084844-8 2007 CONCLUSIONS: Oral administration of E2/NETA reduced ADMA and SDMA concentrations, whereas intranasal administration did not. N,N-dimethylarginine 52-56 cystatin 12, pseudogene Homo sapiens 36-43 17084844-8 2007 CONCLUSIONS: Oral administration of E2/NETA reduced ADMA and SDMA concentrations, whereas intranasal administration did not. symmetric dimethylarginine 61-65 cystatin 12, pseudogene Homo sapiens 36-43 16842799-9 2007 Furthermore, a significant decrease in serum RANTES was observed at the end of 3 months only in the E2/NETA and the raloxifene group (E2/NETA baseline 8690.6+/-3880.0 pg/ml, 3 months 6894.0+/-1720.0 pg/ml, p=0.007; raloxifene baseline 9042.4+/-3765.6 pg/ml, 3 months 6718.1+/-2366.2 pg/ml, p=0.011). Raloxifene Hydrochloride 116-126 cystatin 12, pseudogene Homo sapiens 134-141 17763261-6 2007 The ratio of HDL cholesterol (week 52 to baseline) was 0.944 for 1EV/2DNG and 0.929 for E2/NETA (geometric means). Cholesterol 17-28 cystatin 12, pseudogene Homo sapiens 88-95 17763261-8 2007 HDL2 cholesterol increased by 0.3 +/- 34.4% (1EV/2DNG) and decreased by 6.2 +/- 34.3% (E2/NETA; treatment difference NS); HDL3 cholesterol decreased by 4.4 +/- 19.9% (1EV/2DNG) and 8.2 +/- 17.7% (E2/NETA; treatment difference NS). Cholesterol 5-16 cystatin 12, pseudogene Homo sapiens 87-94 17458902-0 2007 IGF-I plus E2 induces proliferation via activation of ROS-dependent ERKs and JNKs in human breast carcinoma cells. ros 54-57 cystatin 12, pseudogene Homo sapiens 11-13 17458902-1 2007 Induction of 17beta-estradiol (E2) and insulin-like growth factor-I (IGF-I) has been detected in breast carcinoma, however the interaction between E2 and IGF-I in the proliferation of breast carcinoma cells is still unclear. Estradiol 13-29 cystatin 12, pseudogene Homo sapiens 31-33 17458902-1 2007 Induction of 17beta-estradiol (E2) and insulin-like growth factor-I (IGF-I) has been detected in breast carcinoma, however the interaction between E2 and IGF-I in the proliferation of breast carcinoma cells is still unclear. Estradiol 13-29 cystatin 12, pseudogene Homo sapiens 147-149 17458902-4 2007 E2/IGF-I-induced proliferation was blocked by chemical inhibitors of ERKs (PD98059) and JNKs (SP600125). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 75-82 cystatin 12, pseudogene Homo sapiens 0-8 17458902-4 2007 E2/IGF-I-induced proliferation was blocked by chemical inhibitors of ERKs (PD98059) and JNKs (SP600125). pyrazolanthrone 94-102 cystatin 12, pseudogene Homo sapiens 0-8 17458902-5 2007 An increase in the expression of c-Jun protein was detected in E2/IGF-I-treated MCF-7 cells, and this was inhibited by PD98059 and SP600125. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 119-126 cystatin 12, pseudogene Homo sapiens 63-71 17458902-5 2007 An increase in the expression of c-Jun protein was detected in E2/IGF-I-treated MCF-7 cells, and this was inhibited by PD98059 and SP600125. pyrazolanthrone 131-139 cystatin 12, pseudogene Homo sapiens 63-71 17458902-7 2007 An increase in peroxide production was detected in E2/IGF-I-treated cells, and N-acetyl-L-cysteine (NAC) and Tiron (TIR) addition significantly inhibited E2/IGF-I-induced cell proliferation with blocking of the phosphorylation of ERKs and JNKs, and the expression of c-Jun protein. Peroxides 15-23 cystatin 12, pseudogene Homo sapiens 51-59 17458902-7 2007 An increase in peroxide production was detected in E2/IGF-I-treated cells, and N-acetyl-L-cysteine (NAC) and Tiron (TIR) addition significantly inhibited E2/IGF-I-induced cell proliferation with blocking of the phosphorylation of ERKs and JNKs, and the expression of c-Jun protein. Peroxides 15-23 cystatin 12, pseudogene Homo sapiens 154-162 17458902-7 2007 An increase in peroxide production was detected in E2/IGF-I-treated cells, and N-acetyl-L-cysteine (NAC) and Tiron (TIR) addition significantly inhibited E2/IGF-I-induced cell proliferation with blocking of the phosphorylation of ERKs and JNKs, and the expression of c-Jun protein. 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt 109-114 cystatin 12, pseudogene Homo sapiens 154-162 17458902-8 2007 Additionally, 3-OH flavone, baicalein, and quercetin showed effective inhibitory activities against E2/IGF-I-induced proliferation through suppressing proliferative events such as phosphorylation of IRS-1, ERKs, and JNKs proteins, and induction of c-Jun protein and colony formation. 3-oh flavone 14-26 cystatin 12, pseudogene Homo sapiens 100-108 17458902-8 2007 Additionally, 3-OH flavone, baicalein, and quercetin showed effective inhibitory activities against E2/IGF-I-induced proliferation through suppressing proliferative events such as phosphorylation of IRS-1, ERKs, and JNKs proteins, and induction of c-Jun protein and colony formation. baicalein 28-37 cystatin 12, pseudogene Homo sapiens 100-108 17458902-8 2007 Additionally, 3-OH flavone, baicalein, and quercetin showed effective inhibitory activities against E2/IGF-I-induced proliferation through suppressing proliferative events such as phosphorylation of IRS-1, ERKs, and JNKs proteins, and induction of c-Jun protein and colony formation. Quercetin 43-52 cystatin 12, pseudogene Homo sapiens 100-108 17458902-9 2007 These results indicate that IGF-I interacts with E2 to promote the proliferation of breast carcinoma cells via ROS-dependent MAPK activation and c-Jun protein expression. ros 111-114 cystatin 12, pseudogene Homo sapiens 49-51 17458902-10 2007 The structure-related inhibition of E2/IGF-I-induced proliferative events by flavonoids is elucidated. Flavonoids 77-87 cystatin 12, pseudogene Homo sapiens 36-44 17802803-3 2007 The latter increased significantly in Group 1 and insignificantly in Group 2 and did not differ from the normal values in Group 3, at the same time the concentration of E-2 elevated in Groups 1 and 2, rather than in Group 3; the level of DEAS-S increased in Groups 2 and 3 irrespective of the duration of use. Dehydroepiandrosterone Sulfate 238-244 cystatin 12, pseudogene Homo sapiens 169-172 17317046-9 2007 AEs related to the gastrointestinal system were more frequent with oral E2/NETA, and episodes of spotting and bleeding were more frequent with transdermal E2/NETA. aes 0-3 cystatin 12, pseudogene Homo sapiens 72-79 17467203-1 2007 OBJECTIVES: The aim of this study was to demonstrate that the therapeutic efficacy of an estradiol 1mg/drospirenone 2mg (E2/DRSP) preparation is superior to a placebo in postmenopausal Korean women with hot flushes and other climacteric symptoms, and to demonstrate that this treatment is both safe and tolerable. Estradiol 89-98 cystatin 12, pseudogene Homo sapiens 121-128 17467203-1 2007 OBJECTIVES: The aim of this study was to demonstrate that the therapeutic efficacy of an estradiol 1mg/drospirenone 2mg (E2/DRSP) preparation is superior to a placebo in postmenopausal Korean women with hot flushes and other climacteric symptoms, and to demonstrate that this treatment is both safe and tolerable. drospirenone 103-115 cystatin 12, pseudogene Homo sapiens 121-128 17416530-5 2007 The most potent inhibitor among the benzimidazole analogues was (E)-2-(4-trifluoromethylstyryl)-1-methylbenzimidazole with a K(i) value of 430 nM. benzimidazole 36-49 cystatin 12, pseudogene Homo sapiens 64-69 17530099-1 2007 OBJECTIVE: To compare the effects of standard and low dose of 17beta-estradiol/norethisterone acetate (E2/NETA) on body composition and leptin in postmenopausal women at risk of body mass index (BMI) -and waist girth (WG) related cardiovascular and metabolic disease. Estradiol 62-78 cystatin 12, pseudogene Homo sapiens 103-110 17230531-2 2007 Evidence collected in our laboratories has shown that 4-OHE1(E2) are enzymatically oxidized to E1(E2)-3,4-quinones [E1(E2)-3,4-Q], which have the potential to damage DNA by forming predominantly depurinating adducts, 4-OHE1(E2)-1-N3Ade and 4-OHE1(E2)-1-N7Gua, leading to the accumulation of mutations and probably cell transformation. 4-hydroxyestrone 54-60 cystatin 12, pseudogene Homo sapiens 95-103 17230531-2 2007 Evidence collected in our laboratories has shown that 4-OHE1(E2) are enzymatically oxidized to E1(E2)-3,4-quinones [E1(E2)-3,4-Q], which have the potential to damage DNA by forming predominantly depurinating adducts, 4-OHE1(E2)-1-N3Ade and 4-OHE1(E2)-1-N7Gua, leading to the accumulation of mutations and probably cell transformation. 4-hydroxyestrone 54-60 cystatin 12, pseudogene Homo sapiens 116-124 17230531-2 2007 Evidence collected in our laboratories has shown that 4-OHE1(E2) are enzymatically oxidized to E1(E2)-3,4-quinones [E1(E2)-3,4-Q], which have the potential to damage DNA by forming predominantly depurinating adducts, 4-OHE1(E2)-1-N3Ade and 4-OHE1(E2)-1-N7Gua, leading to the accumulation of mutations and probably cell transformation. ,4-quinones 103-114 cystatin 12, pseudogene Homo sapiens 116-124 17230531-2 2007 Evidence collected in our laboratories has shown that 4-OHE1(E2) are enzymatically oxidized to E1(E2)-3,4-quinones [E1(E2)-3,4-Q], which have the potential to damage DNA by forming predominantly depurinating adducts, 4-OHE1(E2)-1-N3Ade and 4-OHE1(E2)-1-N7Gua, leading to the accumulation of mutations and probably cell transformation. ,4-q 124-128 cystatin 12, pseudogene Homo sapiens 95-103 17230531-2 2007 Evidence collected in our laboratories has shown that 4-OHE1(E2) are enzymatically oxidized to E1(E2)-3,4-quinones [E1(E2)-3,4-Q], which have the potential to damage DNA by forming predominantly depurinating adducts, 4-OHE1(E2)-1-N3Ade and 4-OHE1(E2)-1-N7Gua, leading to the accumulation of mutations and probably cell transformation. 4-hydroxyestrone 217-223 cystatin 12, pseudogene Homo sapiens 95-103 17230531-2 2007 Evidence collected in our laboratories has shown that 4-OHE1(E2) are enzymatically oxidized to E1(E2)-3,4-quinones [E1(E2)-3,4-Q], which have the potential to damage DNA by forming predominantly depurinating adducts, 4-OHE1(E2)-1-N3Ade and 4-OHE1(E2)-1-N7Gua, leading to the accumulation of mutations and probably cell transformation. 4-hydroxyestrone 217-223 cystatin 12, pseudogene Homo sapiens 116-124 17230531-2 2007 Evidence collected in our laboratories has shown that 4-OHE1(E2) are enzymatically oxidized to E1(E2)-3,4-quinones [E1(E2)-3,4-Q], which have the potential to damage DNA by forming predominantly depurinating adducts, 4-OHE1(E2)-1-N3Ade and 4-OHE1(E2)-1-N7Gua, leading to the accumulation of mutations and probably cell transformation. )-1-n3ade 226-235 cystatin 12, pseudogene Homo sapiens 95-103 17230531-2 2007 Evidence collected in our laboratories has shown that 4-OHE1(E2) are enzymatically oxidized to E1(E2)-3,4-quinones [E1(E2)-3,4-Q], which have the potential to damage DNA by forming predominantly depurinating adducts, 4-OHE1(E2)-1-N3Ade and 4-OHE1(E2)-1-N7Gua, leading to the accumulation of mutations and probably cell transformation. )-1-n3ade 226-235 cystatin 12, pseudogene Homo sapiens 116-124 17230531-2 2007 Evidence collected in our laboratories has shown that 4-OHE1(E2) are enzymatically oxidized to E1(E2)-3,4-quinones [E1(E2)-3,4-Q], which have the potential to damage DNA by forming predominantly depurinating adducts, 4-OHE1(E2)-1-N3Ade and 4-OHE1(E2)-1-N7Gua, leading to the accumulation of mutations and probably cell transformation. 4-hydroxyestrone 217-223 cystatin 12, pseudogene Homo sapiens 95-103 17230531-2 2007 Evidence collected in our laboratories has shown that 4-OHE1(E2) are enzymatically oxidized to E1(E2)-3,4-quinones [E1(E2)-3,4-Q], which have the potential to damage DNA by forming predominantly depurinating adducts, 4-OHE1(E2)-1-N3Ade and 4-OHE1(E2)-1-N7Gua, leading to the accumulation of mutations and probably cell transformation. 4-hydroxyestrone 217-223 cystatin 12, pseudogene Homo sapiens 116-124 17230531-9 2007 These results demonstrate that MCF-10F cells oxidize 4-OHE2 to E1(E2)-3,4-Q, which react with DNA to form the depurinating N3Ade and N7Gua adducts. 4-hydroxyestradiol 53-59 cystatin 12, pseudogene Homo sapiens 63-71 17570247-3 2007 These, in turn, are oxidized to the quinones, E(2)-3,4-quinone (E(2)-3,4-Q) and E(2)-2,3-Q, which can react with DNA. Quinones 36-44 cystatin 12, pseudogene Homo sapiens 46-52 17570247-3 2007 These, in turn, are oxidized to the quinones, E(2)-3,4-quinone (E(2)-3,4-Q) and E(2)-2,3-Q, which can react with DNA. Quinones 36-44 cystatin 12, pseudogene Homo sapiens 64-70 17570247-10 2007 Depurinating adducts, as well as GSH conjugates, were obtained when E(2)-3,4-Q was incubated with CYP1B1 or control microsomes in a 30-minute reaction, further demonstrating that GSH is present in these recombinant enzyme preparations. Glutathione 179-182 cystatin 12, pseudogene Homo sapiens 68-74 17362937-5 2007 Bisulfite sequencing revealed that E2 and Tam up-regulate expression via demethylation of cytosine in the cytosine-guanosine dinucleotide island of CXCR4 and CXCL12 promoters. hydrogen sulfite 0-9 cystatin 12, pseudogene Homo sapiens 35-45 17362937-5 2007 Bisulfite sequencing revealed that E2 and Tam up-regulate expression via demethylation of cytosine in the cytosine-guanosine dinucleotide island of CXCR4 and CXCL12 promoters. Cytosine 90-98 cystatin 12, pseudogene Homo sapiens 35-45 17362937-5 2007 Bisulfite sequencing revealed that E2 and Tam up-regulate expression via demethylation of cytosine in the cytosine-guanosine dinucleotide island of CXCR4 and CXCL12 promoters. cytosine-guanosine dinucleotide 106-137 cystatin 12, pseudogene Homo sapiens 35-45 17254854-10 2007 hFOB converted androstenedione into E2 and testosterone (TST). hfob 0-4 cystatin 12, pseudogene Homo sapiens 36-55 17254854-10 2007 hFOB converted androstenedione into E2 and testosterone (TST). Androstenedione 15-30 cystatin 12, pseudogene Homo sapiens 36-55 17270221-1 2007 The immortalized human breast epithelial MCF-10F cell line, although estrogen receptor alpha negative, develops cell proliferating activities and invasiveness indicative of neoplastic transformation, after treatment with 17-beta-estradiol (E-2). Estradiol 221-238 cystatin 12, pseudogene Homo sapiens 240-243 17291108-2 2007 The crystal structure of the selective Cs+ ion exchanger D1.6H0.4Ti2SiO7.D2.66H0.34O1.5, known as crystalline silicotitanate or CST, has been determined in both native (D-CST) and in the Cs+-exchanged forms ((Cs, D)-CST) from angle-dispersive and time-of-flight neutron diffraction studies. Cesium 39-41 cystatin 12, pseudogene Homo sapiens 128-131 17302458-6 2007 The carbon spectrum showed two peaks in the carbonyl carbon region of nearly equal intensities at -151.6 degrees C, with E-2 (48%) absorbing downfield of the major Z-2 (52%). Carbon 4-10 cystatin 12, pseudogene Homo sapiens 121-124 17291108-2 2007 The crystal structure of the selective Cs+ ion exchanger D1.6H0.4Ti2SiO7.D2.66H0.34O1.5, known as crystalline silicotitanate or CST, has been determined in both native (D-CST) and in the Cs+-exchanged forms ((Cs, D)-CST) from angle-dispersive and time-of-flight neutron diffraction studies. Cesium 39-41 cystatin 12, pseudogene Homo sapiens 171-174 17291108-2 2007 The crystal structure of the selective Cs+ ion exchanger D1.6H0.4Ti2SiO7.D2.66H0.34O1.5, known as crystalline silicotitanate or CST, has been determined in both native (D-CST) and in the Cs+-exchanged forms ((Cs, D)-CST) from angle-dispersive and time-of-flight neutron diffraction studies. Cesium 39-41 cystatin 12, pseudogene Homo sapiens 171-174 17291108-2 2007 The crystal structure of the selective Cs+ ion exchanger D1.6H0.4Ti2SiO7.D2.66H0.34O1.5, known as crystalline silicotitanate or CST, has been determined in both native (D-CST) and in the Cs+-exchanged forms ((Cs, D)-CST) from angle-dispersive and time-of-flight neutron diffraction studies. cesium cation 39-42 cystatin 12, pseudogene Homo sapiens 128-131 17291108-2 2007 The crystal structure of the selective Cs+ ion exchanger D1.6H0.4Ti2SiO7.D2.66H0.34O1.5, known as crystalline silicotitanate or CST, has been determined in both native (D-CST) and in the Cs+-exchanged forms ((Cs, D)-CST) from angle-dispersive and time-of-flight neutron diffraction studies. cesium cation 39-42 cystatin 12, pseudogene Homo sapiens 171-174 17291108-2 2007 The crystal structure of the selective Cs+ ion exchanger D1.6H0.4Ti2SiO7.D2.66H0.34O1.5, known as crystalline silicotitanate or CST, has been determined in both native (D-CST) and in the Cs+-exchanged forms ((Cs, D)-CST) from angle-dispersive and time-of-flight neutron diffraction studies. cesium cation 39-42 cystatin 12, pseudogene Homo sapiens 171-174 17291108-3 2007 The final fully exchange Cs+ form transformed from D-CST with unit cell parameters a = 11.0704(3) A c = 11.8917(5) A and space group P42/mbc, to one with a = 7.8902(1) A c = 11.9051(4) A and space group P42/mcm. cesium cation 25-28 cystatin 12, pseudogene Homo sapiens 53-56 17291108-4 2007 Rietveld structure refinements of both D-CST and (Cs, D)-CST suggest the transition, and ultimately the selectivity, is driven by changes in the positions of water molecules, in response to the initial introduction of Cs+. Water 158-163 cystatin 12, pseudogene Homo sapiens 41-44 17291108-4 2007 Rietveld structure refinements of both D-CST and (Cs, D)-CST suggest the transition, and ultimately the selectivity, is driven by changes in the positions of water molecules, in response to the initial introduction of Cs+. Water 158-163 cystatin 12, pseudogene Homo sapiens 57-60 17291108-4 2007 Rietveld structure refinements of both D-CST and (Cs, D)-CST suggest the transition, and ultimately the selectivity, is driven by changes in the positions of water molecules, in response to the initial introduction of Cs+. cesium cation 218-221 cystatin 12, pseudogene Homo sapiens 41-44 17291108-4 2007 Rietveld structure refinements of both D-CST and (Cs, D)-CST suggest the transition, and ultimately the selectivity, is driven by changes in the positions of water molecules, in response to the initial introduction of Cs+. cesium cation 218-221 cystatin 12, pseudogene Homo sapiens 57-60 17291108-5 2007 The changes in water position appear to disrupt the D-O-O-D dihedral associated with the CST framework in space group P42/mbc which ultimately leads to the structural transition. Water 15-20 cystatin 12, pseudogene Homo sapiens 89-92 17291108-6 2007 The new geometric arrangement of the water-deuteroxyl network in (Cs, D)-CST suggests that Dwater-Ddeuteroxyl repulsion forced by Cs+ exchange drives the structural transformation. Water 37-42 cystatin 12, pseudogene Homo sapiens 73-76 17291108-6 2007 The new geometric arrangement of the water-deuteroxyl network in (Cs, D)-CST suggests that Dwater-Ddeuteroxyl repulsion forced by Cs+ exchange drives the structural transformation. cesium cation 130-133 cystatin 12, pseudogene Homo sapiens 73-76 17006379-10 2006 Preincubation of THP-1 cells with an ER antagonist, ICI 182780, significantly attenuated the inhibitory effects of E2 and raloxifene. Fulvestrant 52-62 cystatin 12, pseudogene Homo sapiens 115-132 17106250-8 2006 The effect of the EGFR inhibitor AG1517 revealed that E2 and tamoxifen were both equally dependent on EGFR for activation of ERK. AG 1517 33-39 cystatin 12, pseudogene Homo sapiens 54-70 17085380-6 2006 RESULTS: Compared with E2/dienogest and the control group, tibolone treatment was associated with more improvement of sexual performance, including sexual desire, sexual arousal and satisfaction. tibolone 59-67 cystatin 12, pseudogene Homo sapiens 23-35 17203148-2 2006 E-2-Hexenal and E,E-2,4-hexadienal were found to undergo rapid isomerization to produce Z-2-hexenal and a ketene-type compound (probably E-hexa-1,3-dien-1-one), respectively. z-2-hexenal 88-99 cystatin 12, pseudogene Homo sapiens 0-3 17203148-2 2006 E-2-Hexenal and E,E-2,4-hexadienal were found to undergo rapid isomerization to produce Z-2-hexenal and a ketene-type compound (probably E-hexa-1,3-dien-1-one), respectively. z-2-hexenal 88-99 cystatin 12, pseudogene Homo sapiens 18-21 17203148-2 2006 E-2-Hexenal and E,E-2,4-hexadienal were found to undergo rapid isomerization to produce Z-2-hexenal and a ketene-type compound (probably E-hexa-1,3-dien-1-one), respectively. ketene 106-112 cystatin 12, pseudogene Homo sapiens 0-3 17203148-2 2006 E-2-Hexenal and E,E-2,4-hexadienal were found to undergo rapid isomerization to produce Z-2-hexenal and a ketene-type compound (probably E-hexa-1,3-dien-1-one), respectively. ketene 106-112 cystatin 12, pseudogene Homo sapiens 18-21 17203148-2 2006 E-2-Hexenal and E,E-2,4-hexadienal were found to undergo rapid isomerization to produce Z-2-hexenal and a ketene-type compound (probably E-hexa-1,3-dien-1-one), respectively. e-hexa-1,3-dien-1-one 137-158 cystatin 12, pseudogene Homo sapiens 0-3 17203148-2 2006 E-2-Hexenal and E,E-2,4-hexadienal were found to undergo rapid isomerization to produce Z-2-hexenal and a ketene-type compound (probably E-hexa-1,3-dien-1-one), respectively. e-hexa-1,3-dien-1-one 137-158 cystatin 12, pseudogene Homo sapiens 18-21 17203148-6 2006 Although photolysis appears to be an important atmospheric degradation pathway for E-2-hexenal and E,E-2,4-hexadienal, the reversible nature of the photolytic process means that gas phase reactions with OH and NO(3) radicals are ultimately responsible for the atmospheric removal of these compounds. no(3) radicals 210-224 cystatin 12, pseudogene Homo sapiens 83-86 17203148-6 2006 Although photolysis appears to be an important atmospheric degradation pathway for E-2-hexenal and E,E-2,4-hexadienal, the reversible nature of the photolytic process means that gas phase reactions with OH and NO(3) radicals are ultimately responsible for the atmospheric removal of these compounds. no(3) radicals 210-224 cystatin 12, pseudogene Homo sapiens 101-104 16671666-2 2006 Iodine-catalyzed isomerization experiments and computational modeling studies show that the equilibrated system consists predominantly of E-1 and E-2, with E-2 in moderate excess, and with no detectable amounts of the Z (cis) diastereoisomers. Iodine 0-6 cystatin 12, pseudogene Homo sapiens 146-149 16894405-0 2006 Effects of bisphosphonates on prostaglandin E2 and thromboxane B2 production in human whole blood and monocytes stimulated by lipopolysaccharide and A23187. Calcimycin 149-155 cystatin 12, pseudogene Homo sapiens 44-65 16478764-7 2006 RESULTS: Mean total E2 and E2 per mature follicle were significantly higher in clomiphene group without a difference in mean number of mature follicles >18 mm and ovulation rate. Clomiphene 79-89 cystatin 12, pseudogene Homo sapiens 20-29 16671666-1 2006 The possible competition of Z/E versus hydrogen-shift isomerization in (E)-5-phenyl-3-penten-2-one (E-1) and (E)-5-phenyl-4-penten-2-one (E-2) was studied, both experimentally and theoretically. Hydrogen 39-47 cystatin 12, pseudogene Homo sapiens 138-141 16671666-1 2006 The possible competition of Z/E versus hydrogen-shift isomerization in (E)-5-phenyl-3-penten-2-one (E-1) and (E)-5-phenyl-4-penten-2-one (E-2) was studied, both experimentally and theoretically. (e)-5-phenyl-4-penten-2-one 109-136 cystatin 12, pseudogene Homo sapiens 138-141 16541422-4 2006 RESULTS: mRNAs of both enzymes were detected in all prostate cancer cell lines examined, and the synthesis of estrone (E(1)) and estradiol (E(2)) was also confirmed in these cell lines. Estradiol 129-138 cystatin 12, pseudogene Homo sapiens 140-144 16402924-8 2006 Progesterone (Pg), E2 and EGF incubated under the same conditions had a stimulatory effect on [3H]-thymidine incorporation into MCF-7 cells, whereas TGF-beta2 inhibited this parameter. Tritium 95-97 cystatin 12, pseudogene Homo sapiens 19-29 16494924-1 2006 Since natural estrogens such as 17beta-estradiol (E2) and estrone (E1) are excreted daily by humans, E2 and E1, which are classified as inevitable endocrine-disrupting chemicals, are always present in sewage wastewater. Estradiol 32-48 cystatin 12, pseudogene Homo sapiens 101-110 16494924-1 2006 Since natural estrogens such as 17beta-estradiol (E2) and estrone (E1) are excreted daily by humans, E2 and E1, which are classified as inevitable endocrine-disrupting chemicals, are always present in sewage wastewater. Estrone 58-65 cystatin 12, pseudogene Homo sapiens 101-110 16704542-7 2006 RESULTS: High concentrations of E2 and UDCA prevented DCA-induced decrease in cell viability, increase in enzyme activity and apoptosis evaluated both by 4",6-diamidino-2-phenylindole dihydrochloride (DAPI) and TdT-mediated dUTP nick-end labeling (TUNEL) assays. 4",6-diamidino-2-phenylindole dihydrochloride 154-199 cystatin 12, pseudogene Homo sapiens 32-43 16704542-7 2006 RESULTS: High concentrations of E2 and UDCA prevented DCA-induced decrease in cell viability, increase in enzyme activity and apoptosis evaluated both by 4",6-diamidino-2-phenylindole dihydrochloride (DAPI) and TdT-mediated dUTP nick-end labeling (TUNEL) assays. DAPI 201-205 cystatin 12, pseudogene Homo sapiens 32-43 16704542-7 2006 RESULTS: High concentrations of E2 and UDCA prevented DCA-induced decrease in cell viability, increase in enzyme activity and apoptosis evaluated both by 4",6-diamidino-2-phenylindole dihydrochloride (DAPI) and TdT-mediated dUTP nick-end labeling (TUNEL) assays. deoxyuridine triphosphate 224-228 cystatin 12, pseudogene Homo sapiens 32-43 16464079-1 2006 We report the first structural data for bis(diarylamine) "bipolarons": we have isolated and crystallographically characterized salts of the dications obtained by two-electron oxidation of E-4,4"-bis[di(p-anisyl)amino]stilbene and E,E-2,5-bis{4-[di(p-anisyl)amino]styryl}-3,4-di(n-butoxy)thiophene, [1](2+) and [2](2+) respectively. bis(diarylamine) " 40-58 cystatin 12, pseudogene Homo sapiens 232-235 16402924-8 2006 Progesterone (Pg), E2 and EGF incubated under the same conditions had a stimulatory effect on [3H]-thymidine incorporation into MCF-7 cells, whereas TGF-beta2 inhibited this parameter. Thymidine 99-108 cystatin 12, pseudogene Homo sapiens 19-29 16862219-9 2006 In models of ischemia-reperfusion, E2/ER is antiapoptotic for cardiomyocytes, exerting the protective actions via PI3K and p38 MAP kinases and suppressing the generation of reactive oxygen species. Reactive Oxygen Species 173-196 cystatin 12, pseudogene Homo sapiens 35-40 16838069-8 2006 Antiparallel purine motif oligonucleotides targeted at E-1 or E-2 selectively formed strong triplex DNA (K(d) approximately 10(-7) M) at 37 degrees C. Transfection of tie-1 reporter constructs with triplex DNA at E-1, but not E-2, specifically inhibited tie-1 promoter activity by up to 75% compared with control oligonucleotides in endothelial cells. purine 13-19 cystatin 12, pseudogene Homo sapiens 62-65 16838069-8 2006 Antiparallel purine motif oligonucleotides targeted at E-1 or E-2 selectively formed strong triplex DNA (K(d) approximately 10(-7) M) at 37 degrees C. Transfection of tie-1 reporter constructs with triplex DNA at E-1, but not E-2, specifically inhibited tie-1 promoter activity by up to 75% compared with control oligonucleotides in endothelial cells. Oligonucleotides 26-42 cystatin 12, pseudogene Homo sapiens 62-65 16174721-9 2005 RESULTS: The mean (95% confidence interval) of the time-average free testosterone levels during TTP treatment was 7.5 (4.9-9.9) pg/ml; 26.0 (17.2-34.6) pmol/liter (with E2), and 6.9 (4.9-8.8) pg/ml; 23.9 (17.2-30.5) pmol/liter (with E2 and MPA). Testosterone 69-81 cystatin 12, pseudogene Homo sapiens 233-243 16294275-12 2005 In co-cultures, where MG-63 or SaOS-2 cells were present, E2 and Te inhibited osteoclast formation in a dose-dependent manner. Magnesium 22-24 cystatin 12, pseudogene Homo sapiens 58-67 16294275-14 2005 The effects of E2 and Te on osteoclast formation and bone resorption were completely antagonized by an E2 receptor (ER) antagonist, ICI 182,780, and an androgen receptor (AR) antagonist, flutamide, suggesting ER- and AR-mediated mechanisms, respectively, in these cultures. Flutamide 187-196 cystatin 12, pseudogene Homo sapiens 15-24 16209479-1 2005 [structure: see text] New conjunctive reagents E-2 and Z-3 can be used, after transmetalation, in Negishi couplings with vinyl and aryl iodides. aryl iodides 131-143 cystatin 12, pseudogene Homo sapiens 47-58 16303616-0 2005 Captopril effect on prostaglandin E2, thromboxane B2 and proteinuria in lupus nephritis patients. Captopril 0-9 cystatin 12, pseudogene Homo sapiens 34-52 15878502-2 2005 When in vitro binding studies using AD brain homogenates were carried out with a series of styrylpyridine derivatives, (E)-2-Bromo-5-(4-dimethylaminostyryl)pyridine (7) with a dimethylamino group showed the highest binding affinity. Dimethyl amidogen 136-149 cystatin 12, pseudogene Homo sapiens 119-124 16533015-2 2005 Monoclonal antibodies (MAb) to 4-OHE1(E2)-2-N-acetylcysteine [4-OHE1(E2)-2-NAcCys] were developed and characterized by immunological and spectroscopic studies. -2-n-acetylcysteine 41-60 cystatin 12, pseudogene Homo sapiens 31-40 16533015-2 2005 Monoclonal antibodies (MAb) to 4-OHE1(E2)-2-N-acetylcysteine [4-OHE1(E2)-2-NAcCys] were developed and characterized by immunological and spectroscopic studies. -2-n-acetylcysteine 41-60 cystatin 12, pseudogene Homo sapiens 62-71 16533015-12 2005 Capillary electrophoresis (CE) with field-amplified sample stacking in absorbance detection mode and laser-induced low temperature luminescence measurements were used to identify and quantitate the 4-OHE1(E2)-2-NAcCys conjugates and related compounds released from the affinity column. -naccys 210-217 cystatin 12, pseudogene Homo sapiens 198-207 15893312-3 2005 The effect of E2 was sensitive to Iberiotoxin, Charybdotoxin and TEA and can be elicited in the presence of the anti-estrogen ICI 182780 or be mimicked by the membrane impermeant form E2/BSA. iberiotoxin 34-45 cystatin 12, pseudogene Homo sapiens 184-190 15893312-3 2005 The effect of E2 was sensitive to Iberiotoxin, Charybdotoxin and TEA and can be elicited in the presence of the anti-estrogen ICI 182780 or be mimicked by the membrane impermeant form E2/BSA. Charybdotoxin 47-60 cystatin 12, pseudogene Homo sapiens 184-190 15940067-6 2005 RESULTS: Mean FA values of ALS patients in the ROIs along the DTT-CST (bulbar-onset: 0.574, limb-onset: 0.594) were significantly lower than those of controls (DTT-CST: 0.629) (p<0.05). Dithiothreitol 62-65 cystatin 12, pseudogene Homo sapiens 66-69 16104691-1 2005 Cyclohexynes can be generated efficiently from 1-cyclohexenyliodonium salts with acetate or other bases via the E2 and E1 mechanism. 1-cyclohexenyliodonium salts 47-75 cystatin 12, pseudogene Homo sapiens 112-121 16104691-1 2005 Cyclohexynes can be generated efficiently from 1-cyclohexenyliodonium salts with acetate or other bases via the E2 and E1 mechanism. Acetates 81-88 cystatin 12, pseudogene Homo sapiens 112-121 15688382-7 2005 Incubation of HCA-7 cancer cells for 24-96 hr with either stilbene derivative (1-50 microM) decreased prostaglandin E-2 (PGE-2) production, but only resveratrol decreased COX-2 protein expression. Stilbenes 58-66 cystatin 12, pseudogene Homo sapiens 116-119 23674952-4 2005 RESULTS: In comparison to placebo, after both, two and eight months administration of Maca-GO capsules to EPMW, level of FSH significantly (P<0.05) decreased with a simultaneous significant (P<0.05) increase in the LH level, resulting in significant (P<0.05) increase in both E2 and PG, after eight months of Maca-GO treatment only. maca-go 86-93 cystatin 12, pseudogene Homo sapiens 285-294 15878502-2 2005 When in vitro binding studies using AD brain homogenates were carried out with a series of styrylpyridine derivatives, (E)-2-Bromo-5-(4-dimethylaminostyryl)pyridine (7) with a dimethylamino group showed the highest binding affinity. azastilbene 91-105 cystatin 12, pseudogene Homo sapiens 119-124 15878502-4 2005 (E)-2-Iodo-5-(4-dimethylaminostyryl)pyridine, the iodo derivative of compound 7, also stained senile plaques in human AD sections. iodo 50-54 cystatin 12, pseudogene Homo sapiens 0-5 15823831-8 2005 Baseline values of estrone sulfate (E1S), around 1.0-1.1 nmol/l, were increased to 44.7 nmol/l by E2/NETA and to only 1.7 nmol/l by tibolone (p < 0.001). estrone sulfate 19-34 cystatin 12, pseudogene Homo sapiens 98-105 15823831-8 2005 Baseline values of estrone sulfate (E1S), around 1.0-1.1 nmol/l, were increased to 44.7 nmol/l by E2/NETA and to only 1.7 nmol/l by tibolone (p < 0.001). Estrone 36-39 cystatin 12, pseudogene Homo sapiens 98-105 15991845-2 2005 MATERIALS AND METHODS: The study of the E2 and F2alpha (prostaglandins levels in the blood and mucous coat of the stomach was conducted in 20 patients with stomach ulcer, 15 patients with osteoarthritis taking diclofenac and 16 patients taking celecoxib. Prostaglandins 56-70 cystatin 12, pseudogene Homo sapiens 40-54 15745935-9 2005 CONCLUSIONS: We conclude that in elderly men dependent on DHEAS levels, 44-72% of E2 and 34-54% of E1 originate directly or indirectly from the testes. Dehydroepiandrosterone Sulfate 58-63 cystatin 12, pseudogene Homo sapiens 82-91 15193722-3 2004 The extractables have been identified as acetic acid, butyric acid, and E-2-ethyl-2-hexenoic acid (E-EHA) by LC/UV, LC/MS and NMR. e-eha 99-104 cystatin 12, pseudogene Homo sapiens 72-75 15571401-6 2004 These results are interpreted as indicating the presence of two species, namely Z- and E-2-(carboxymethylene)-1,2-dihydropyridines (2-13), resulting from conjugate 1,4-addition of H(2)O to 2-4. Water 180-185 cystatin 12, pseudogene Homo sapiens 87-90 15579793-8 2004 Overall per treatment group, serum E2 and inhibin B concentrations significantly increased only in the two highest FSH-CTP dose groups, reaching peak concentrations at d 3 in the 30-microg group and at d 5 in the 60-microg group. Cytidine Triphosphate 119-122 cystatin 12, pseudogene Homo sapiens 35-51 15491151-7 2004 Conversion of all of the lipoyl groups in the E2 60mer to the oxidized form (E2(ox)) greatly reduced k(cat) and the K(m) of PDK2 for ATP. Adenosine Triphosphate 133-136 cystatin 12, pseudogene Homo sapiens 77-83 15172088-6 2004 The E2/NETA group developed a significant lowering of total cholesterol, HDL, and LDL, but no significant changes of TG levels. Cholesterol 60-71 cystatin 12, pseudogene Homo sapiens 4-11 15225808-8 2004 Using ovalbumin bound to E2 (Ov-E2) linked to Eu (Eu-Ov-E2), to assess specific membrane binding sites, we observed that membranal binding was down regulated by JKF by 70-80%. membranal 121-130 cystatin 12, pseudogene Homo sapiens 25-27 15157572-11 2004 The estrogen receptor antagonist 4-hydroxytamoxifen could attenuate these inhibitive effects of both E2 and ZEA. hydroxytamoxifen 33-51 cystatin 12, pseudogene Homo sapiens 101-111 15157572-12 2004 Interestingly, Both E2 and ZEA could promote basal and TCDD-induced CYP1B1 activity but with no effect on CYP1B1 mRNA expression. Polychlorinated Dibenzodioxins 55-59 cystatin 12, pseudogene Homo sapiens 20-30 15225808-1 2004 In cultured human vascular smooth muscle cells (VSMC), estradiol-17beta (E2) induced a biphasic effect on DNA synthesis, i.e., stimulation at low concentrations and inhibition at high concentrations. vsmc 48-52 cystatin 12, pseudogene Homo sapiens 73-75 15167309-6 2004 Similarly, both treatments increased the active MMP-2 fraction, although only the raloxifene-associated increase acquired significance (raloxifene baseline: 24.9 +/- 8.6 ng/mL; 6 months: 31.6 +/- 15.3 ng/mL, P = 0.045) (E2/NETA baseline: 21.7 +/- 5.7 ng/mL; 6 months: 27.4 +/- 5.8 ng/mL, P = 0.128). Raloxifene Hydrochloride 82-92 cystatin 12, pseudogene Homo sapiens 220-227 15225808-8 2004 Using ovalbumin bound to E2 (Ov-E2) linked to Eu (Eu-Ov-E2), to assess specific membrane binding sites, we observed that membranal binding was down regulated by JKF by 70-80%. membranal 121-130 cystatin 12, pseudogene Homo sapiens 29-34 15225808-1 2004 In cultured human vascular smooth muscle cells (VSMC), estradiol-17beta (E2) induced a biphasic effect on DNA synthesis, i.e., stimulation at low concentrations and inhibition at high concentrations. Estradiol 55-71 cystatin 12, pseudogene Homo sapiens 73-75 15225808-8 2004 Using ovalbumin bound to E2 (Ov-E2) linked to Eu (Eu-Ov-E2), to assess specific membrane binding sites, we observed that membranal binding was down regulated by JKF by 70-80%. membranal 121-130 cystatin 12, pseudogene Homo sapiens 53-58 14979720-8 2004 These were found to be (a) the cytoplasmic Na(+) and K(+) binding sites, via changes in Na(+) or K(+) concentration or their dissociation constants, (b) ATP phosphorylation (as a substrate), via a change in its rate constant, and (c) the position of the E(2)<==>E(1) equilibrium. Adenosine Triphosphate 153-156 cystatin 12, pseudogene Homo sapiens 254-258 15252669-8 2004 In the case of diboranes 4, 5 and 1-(dimesitylboryl)-8-(diphenylboryl)naphthalene (6), two distinct waves are observed at E(1/2)-2.14 and -2.56 V for 4, E(1/2)-2.26 and -2.78 V for 5, and E(1/2)-2.41 and -2.84 V for 6. diborane 15-24 cystatin 12, pseudogene Homo sapiens 122-130 15252669-8 2004 In the case of diboranes 4, 5 and 1-(dimesitylboryl)-8-(diphenylboryl)naphthalene (6), two distinct waves are observed at E(1/2)-2.14 and -2.56 V for 4, E(1/2)-2.26 and -2.78 V for 5, and E(1/2)-2.41 and -2.84 V for 6. diborane 15-24 cystatin 12, pseudogene Homo sapiens 153-161 15252669-8 2004 In the case of diboranes 4, 5 and 1-(dimesitylboryl)-8-(diphenylboryl)naphthalene (6), two distinct waves are observed at E(1/2)-2.14 and -2.56 V for 4, E(1/2)-2.26 and -2.78 V for 5, and E(1/2)-2.41 and -2.84 V for 6. 1-(dimesitylboryl)-8-(diphenylboryl)naphthalene 34-81 cystatin 12, pseudogene Homo sapiens 122-130 15252669-8 2004 In the case of diboranes 4, 5 and 1-(dimesitylboryl)-8-(diphenylboryl)naphthalene (6), two distinct waves are observed at E(1/2)-2.14 and -2.56 V for 4, E(1/2)-2.26 and -2.78 V for 5, and E(1/2)-2.41 and -2.84 V for 6. 1-(dimesitylboryl)-8-(diphenylboryl)naphthalene 34-81 cystatin 12, pseudogene Homo sapiens 153-161 15065771-8 2004 Nevertheless, the use of beta-damascenone seems to be more convenient because this compound appears in beer in higher concentrations than E-2-nonenal, thus making it easier to measure. beta-damascenone 25-41 cystatin 12, pseudogene Homo sapiens 138-141 15116840-3 2004 This trend for E2 and NP is similar to that obtained by other researchers for moderately hydrophobic compounds including polycyclic aromatic hydrocarbons with three or four rings. Polycyclic Aromatic Hydrocarbons 121-153 cystatin 12, pseudogene Homo sapiens 15-24 14749051-2 2004 The present study was designed to investigate whether porcine mammary gland was a source of E(2), and to test the influence of individual and combined effects of exogenous progesterone and estradiol benzoate (EB) on the secretion of E(2). estradiol 3-benzoate 189-207 cystatin 12, pseudogene Homo sapiens 233-237 14749051-8 2004 Increased concentrations of plasma E(2) collected only from P(4)-treated animals suggested that progesterone activated enzymes involved in steroidogenesis in porcine mammary gland, or those utilized in its metabolism. Progesterone 96-108 cystatin 12, pseudogene Homo sapiens 35-39 14559847-2 2003 We report here our novel findings that human CYP3A7 has a distinct high catalytic activity for the NADPH-dependent 16alpha-hydroxylation of estrone (E(1); at 10 nM to 200 microM substrate concentrations) but not for the 16alpha-hydroxylation of 17beta-estradiol (E(2)). NADP 99-104 cystatin 12, pseudogene Homo sapiens 263-267 14993044-9 2003 Using a formulation of E2 that rapidly delivers the steroid, a necessary condition for acute therapy of an ongoing stroke, we demonstrated that 100 mg E2/kg could protect brain tissue for up to 3 h after the onset of the stroke. Steroids 52-59 cystatin 12, pseudogene Homo sapiens 151-156 14602769-8 2003 Subjects with FEI, c-bioE(2), and E(2) levels below the median showed higher rates of bone loss at the lumbar spine and the femoral neck as well as higher speed-of-sounds decrease at the calcaneus with respect to men with FEI, c-bioE(2), and E(2) levels above the median. c-bioe 227-233 cystatin 12, pseudogene Homo sapiens 34-38 15638395-7 2004 The results suggested that E2 and P were required to convert ALA to PpIX in epithelial cells and increased PpIX concentration in a time-dependent fashion. 5-amino levulinic acid 61-64 cystatin 12, pseudogene Homo sapiens 27-35 15638395-7 2004 The results suggested that E2 and P were required to convert ALA to PpIX in epithelial cells and increased PpIX concentration in a time-dependent fashion. protoporphyrin IX 68-72 cystatin 12, pseudogene Homo sapiens 27-35 15638395-7 2004 The results suggested that E2 and P were required to convert ALA to PpIX in epithelial cells and increased PpIX concentration in a time-dependent fashion. protoporphyrin IX 107-111 cystatin 12, pseudogene Homo sapiens 27-35 14559847-2 2003 We report here our novel findings that human CYP3A7 has a distinct high catalytic activity for the NADPH-dependent 16alpha-hydroxylation of estrone (E(1); at 10 nM to 200 microM substrate concentrations) but not for the 16alpha-hydroxylation of 17beta-estradiol (E(2)). Estrone 140-147 cystatin 12, pseudogene Homo sapiens 263-267 14559847-6 2003 Enzyme kinetic analysis showed that the maximal velocity and substrate-binding affinity (1/K(m)) for CYP3A7-mediated 16alpha-hydroxylation of E(1) were both approximately 10 times higher than those for E(2), thereby giving the maximal velocity:K(m) ratio of >100 times higher for the 16alpha-hydroxylation of E(1) than for E(2). 16alpha 117-124 cystatin 12, pseudogene Homo sapiens 202-206 14559847-6 2003 Enzyme kinetic analysis showed that the maximal velocity and substrate-binding affinity (1/K(m)) for CYP3A7-mediated 16alpha-hydroxylation of E(1) were both approximately 10 times higher than those for E(2), thereby giving the maximal velocity:K(m) ratio of >100 times higher for the 16alpha-hydroxylation of E(1) than for E(2). 16alpha 117-124 cystatin 12, pseudogene Homo sapiens 326-330 12532375-7 2003 The ring design, with respect to the position of the steroid layer(s), affected the release of P and E2 from the vaginal rings. Steroids 53-60 cystatin 12, pseudogene Homo sapiens 95-103 14517261-4 2003 Here we show that a strictly conserved E2 asparagine residue is critical for catalysis of E2- and E2/RING E3-dependent isopeptide bond formation, but dispensable for upstream and downstream reactions of Ub thiol ester formation. Estradiol 39-41 cystatin 12, pseudogene Homo sapiens 90-108 14517261-4 2003 Here we show that a strictly conserved E2 asparagine residue is critical for catalysis of E2- and E2/RING E3-dependent isopeptide bond formation, but dispensable for upstream and downstream reactions of Ub thiol ester formation. Asparagine 42-52 cystatin 12, pseudogene Homo sapiens 90-108 12785865-1 2003 (E)-2"-Fluoromethylene-2"-deoxycitidine-5"-diphosphate (FMCDP) is a potent time-dependent inactivator of the enzyme Ribonucleotide Reductase, which operates by destructing an essential tyrosil radical and performing a covalent addition to an active site residue. fmcdp 56-61 cystatin 12, pseudogene Homo sapiens 0-5 12785865-1 2003 (E)-2"-Fluoromethylene-2"-deoxycitidine-5"-diphosphate (FMCDP) is a potent time-dependent inactivator of the enzyme Ribonucleotide Reductase, which operates by destructing an essential tyrosil radical and performing a covalent addition to an active site residue. tyrosil radical 185-200 cystatin 12, pseudogene Homo sapiens 0-5 12547830-2 2003 Recently, we noticed the ends of loop E-2 are linked by an ion pair between residues Arg-177 and Asp-190, near the highly conserved disulfide bond. Arginine 85-88 cystatin 12, pseudogene Homo sapiens 38-41 12547830-2 2003 Recently, we noticed the ends of loop E-2 are linked by an ion pair between residues Arg-177 and Asp-190, near the highly conserved disulfide bond. Aspartic Acid 97-100 cystatin 12, pseudogene Homo sapiens 38-41 12547830-2 2003 Recently, we noticed the ends of loop E-2 are linked by an ion pair between residues Arg-177 and Asp-190, near the highly conserved disulfide bond. Disulfides 132-141 cystatin 12, pseudogene Homo sapiens 38-41 12547830-8 2003 Our results indicate that the loop E-2 ion pair is important for rhodopsin stability and thus suggest that retinitis pigmentosa observed in patients with Asp-190 mutations may in part be the result of thermally unstable rhodopsin proteins. Aspartic Acid 154-157 cystatin 12, pseudogene Homo sapiens 35-38 12774850-5 2003 The aspirin effects were apparently unrelated to prostaglandin biosynthesis inhibition, since although these cells were found to express high levels of cyclooxygenase 1 (COX-1) and low levels of COX-2 proteins, they did not produce any measurable net amounts of prostaglandins, based on both utilization of radiolabelled arachidonic acid and the radioimmunoassay of prostaglandins E2 and F2 alpha. Aspirin 4-11 cystatin 12, pseudogene Homo sapiens 381-396 12696901-8 2003 Under the catalysis of a Pd(0) complex, the halohydroxylation products, that is, E-2-halo-1-phenylsulfinyl-1-alken-3-ols, can undergo Sonogashira, Suzuki, and Negishi cross-coupling reactions leading to Z-2-substituted-1-phenylsulfonyl-1-alken-3-ols. pd(0) 25-30 cystatin 12, pseudogene Homo sapiens 81-84 12696901-8 2003 Under the catalysis of a Pd(0) complex, the halohydroxylation products, that is, E-2-halo-1-phenylsulfinyl-1-alken-3-ols, can undergo Sonogashira, Suzuki, and Negishi cross-coupling reactions leading to Z-2-substituted-1-phenylsulfonyl-1-alken-3-ols. sonogashira 134-145 cystatin 12, pseudogene Homo sapiens 81-84 12696901-8 2003 Under the catalysis of a Pd(0) complex, the halohydroxylation products, that is, E-2-halo-1-phenylsulfinyl-1-alken-3-ols, can undergo Sonogashira, Suzuki, and Negishi cross-coupling reactions leading to Z-2-substituted-1-phenylsulfonyl-1-alken-3-ols. z-2-substituted-1-phenylsulfonyl-1-alken-3-ols 203-249 cystatin 12, pseudogene Homo sapiens 81-84 12463531-6 2002 Intracellular glutathione concentration in the oocytes cultured in the medium containing both E2 and EGF was also significantly higher (12.1 pmol per oocyte) than that of oocytes cultured in the medium with E2 or EGF alone or without both. Glutathione 14-25 cystatin 12, pseudogene Homo sapiens 94-104 12751748-0 2003 Formation of prostaglandin E2, leukotriene B4 and 8-isoprostane in alveolar macrophages by ultrafine particles of elemental carbon. Carbon 124-130 cystatin 12, pseudogene Homo sapiens 27-45 12466387-3 2002 In this study, we report that estradiol (E(2)) and IL-1beta exert a synergistic stimulatory action on RANTES (regulated upon activation, normal T cell expressed, and secreted) expression by endometriotic cells. Estradiol 30-39 cystatin 12, pseudogene Homo sapiens 41-46 12580508-1 2003 The analysis of E-2-nonenal is of considerable interest for the brewery industry as this compound is claimed to be responsible for a paper/cardboard unpleasant flavour. cardboard 139-148 cystatin 12, pseudogene Homo sapiens 16-19 12553013-4 2002 Both E2 and Z (30 nM; 24 h) suppressed PTP gamma by approximately 56% in MCF-7 cells and these effects were completely blocked by 1 mM of ICI. ici 138-141 cystatin 12, pseudogene Homo sapiens 5-13 12553013-6 2002 Interestingly, both E2 and Z suppressed PTP gamma by approximately 45% in MDA-MB-231 cells transfected with ER alpha, and these effects were completely blocked by 100 nM of ICI. ici 173-176 cystatin 12, pseudogene Homo sapiens 20-28 12062679-1 2002 Polymyxins B(1), E(1) (colistin A) and E(2) (colistin B) were subjected to degradation in aqueous solutions of different pH values (1.4, 3.4, 5.4 and 7.4) and at different temperatures (37, 50 and 60 degrees C) in order to investigate the characteristics of decomposition. Colistin b 45-55 cystatin 12, pseudogene Homo sapiens 39-43 12450317-6 2002 Forskolin-induced increase in E2 and P4 production was attenuated by CRH. Colforsin 0-9 cystatin 12, pseudogene Homo sapiens 30-39 12163134-4 2002 E(2), E(1) and 16alpha-hydroxyestrone (16alpha-OHE(1)) were not pro-oxidants and were rather weak antioxidants, while the 2- and 4-hydroxyestrogens demonstrated both properties inducing DNA strand breaks damage as well as inhibiting lipid peroxidation. 16-hydroxyestrone 39-50 cystatin 12, pseudogene Homo sapiens 0-4 12440482-3 2002 Lysis resulted from poreformation in the RBC membranes and was completely prevented by concurrent exposure to Congo red We demonstrate that human serum, purified ApoE from human plasma, and recombinant isoforms of ApoE neutralize the Abeta(25-35) cytotoxicity: the E2 and E4 isoforms were marginally more effective than E3. UNII-042A8N37WH 234-239 cystatin 12, pseudogene Homo sapiens 265-274 11821457-7 2002 Treatment with anastrozole suppressed plasma levels of E(1), E(2), and E(1)S by a mean of 81.0%, 84.9%, and 93.5%, respectively, whereas treatment with letrozole caused a corresponding decrease of 84.3%, 87.8% and 98.0%, respectively. Anastrozole 15-26 cystatin 12, pseudogene Homo sapiens 61-65 11973443-1 2002 OBJECTIVE: Two prospective multicenter, double-blind, randomized, controlled trials were conducted to examine the safety and efficacy of three once-a-week continuous combined 17beta-estradiol/levonorgestrel (E2/LNG) transdermal systems (E2 0.045 mg/day with 0.015, 0.030, and 0.040 mg/day LNG) for the treatment of vasomotor symptoms and prevention of estrogen-induced endometrial hyperplasia in healthy, postmenopausal women. Levonorgestrel 192-206 cystatin 12, pseudogene Homo sapiens 208-214 11908961-3 2002 The structures of these molecules were determined by interpretation of 1H and 13C NMR spectra, and they were shown to be closely related to the previously reported cyclotheonamides E (1), E2, and E3 (2). 13c 78-81 cystatin 12, pseudogene Homo sapiens 188-198 11908961-3 2002 The structures of these molecules were determined by interpretation of 1H and 13C NMR spectra, and they were shown to be closely related to the previously reported cyclotheonamides E (1), E2, and E3 (2). cyclotheonamides 164-180 cystatin 12, pseudogene Homo sapiens 188-198 11731181-1 2001 OBJECTIVES: to compare the patterns of a 17 beta-estradiol (E(2)) gel containing 0.6 mg/g (1.5 mg E(2) per day, Gelestra); with the transdermal delivery system (Estraderm TTS 50) applied every 3 days over a 14-day period to women in spontaneous or surgical menopause. Estradiol 41-58 cystatin 12, pseudogene Homo sapiens 60-64 11857093-2 2002 We hypothesized that the retention of Ca (calcium) and P (phosphorus) would be improved by an E2 and Prog replacement. Calcium 42-49 cystatin 12, pseudogene Homo sapiens 94-105 11857093-2 2002 We hypothesized that the retention of Ca (calcium) and P (phosphorus) would be improved by an E2 and Prog replacement. Phosphorus 55-56 cystatin 12, pseudogene Homo sapiens 94-105 11857093-2 2002 We hypothesized that the retention of Ca (calcium) and P (phosphorus) would be improved by an E2 and Prog replacement. Phosphorus 58-68 cystatin 12, pseudogene Homo sapiens 94-105 11300910-2 2001 The rate-surfactant profiles for the HO(-)- and AcO(-)-catalyzed ring closure of two ethyl hydantoates, E2 and E3, to hydantoins with three cetyltrimethylammonium salts (CTAX, X = Br(-), Cl(-), or AcO(-)) are measured in 0.02 and 0.2 M acetate buffers 50% base with starting pH 4.65. ethyl hydantoates 85-102 cystatin 12, pseudogene Homo sapiens 104-113 11552294-4 2001 In a competitive binding assay, E2 and DES showed inhibition of 17 beta-[3H]estradiol binding to the rat uterus ER with an IC50 of 1.0 nM and 0.5 nM, respectively. beta-[3h]estradiol 67-85 cystatin 12, pseudogene Homo sapiens 32-42 11444108-10 2001 In vitro exposure to iron significantly enhanced lipid peroxidation in hepatic homogenates from untreated, melatonin-treated, or E2-injected hamsters; in the hepatic homogenates of hamsters given both E2 and melatonin, ferrous sulfate failed to augment lipid peroxidation. Iron 21-25 cystatin 12, pseudogene Homo sapiens 201-217 11248142-7 2001 On combining E2 with either BPA or o,p"-DDT at approximately equieffective concentrations corresponding to molar mixture ratios between 1:20,000 and 1:100,000 (E2:BPA or o,p"-DDT), substantial modulations of the effects of E2 became discernible. o,p'-DDT 35-43 cystatin 12, pseudogene Homo sapiens 160-166 11522337-5 2001 Moreover, this study demonstrates that adrenal androgen, androstenedione, is converted to estrone (E(1)) and estradiol (E(2)) in synoviocytes by aromatase which is positively regulated by glucocorticoids such as dexamethasone. Androstenedione 57-72 cystatin 12, pseudogene Homo sapiens 120-124 11522337-5 2001 Moreover, this study demonstrates that adrenal androgen, androstenedione, is converted to estrone (E(1)) and estradiol (E(2)) in synoviocytes by aromatase which is positively regulated by glucocorticoids such as dexamethasone. Estradiol 109-118 cystatin 12, pseudogene Homo sapiens 120-124 11522337-5 2001 Moreover, this study demonstrates that adrenal androgen, androstenedione, is converted to estrone (E(1)) and estradiol (E(2)) in synoviocytes by aromatase which is positively regulated by glucocorticoids such as dexamethasone. Dexamethasone 212-225 cystatin 12, pseudogene Homo sapiens 120-124 11543655-6 2001 These Fabs, which share the same complementarity-determining region DNA sequences, had higher affinity than other anti-HCV/E2 Fabs but showed no NOB activity even at the highest concentrations. FAB protocol 6-10 cystatin 12, pseudogene Homo sapiens 119-125 11543655-7 2001 Binding of Fabs to HCV/E2 caused conformational changes modifying Fab-binding patterns and reducing, with a negative synergistic effect, Fab-mediated NOB activity. FAB protocol 11-15 cystatin 12, pseudogene Homo sapiens 19-25 11543655-7 2001 Binding of Fabs to HCV/E2 caused conformational changes modifying Fab-binding patterns and reducing, with a negative synergistic effect, Fab-mediated NOB activity. nitrosobenzene 150-153 cystatin 12, pseudogene Homo sapiens 19-25 11389924-9 2001 Co-addition of 1 nM E2 and 5 ng/ml EGF for 24 h reduced [methyl-(3)H]thymidine incorporation, when data are compared to E2- or EGF-treated cultures. Thymidine 69-78 cystatin 12, pseudogene Homo sapiens 20-28 11273848-7 2001 LDL cholesterol in men with the E2 allele was significantly lower in drinkers than in nondrinkers but was significantly higher in drinkers than in nondrinkers in men with the E4 allele. Cholesterol 4-15 cystatin 12, pseudogene Homo sapiens 32-34 11273848-10 2001 Multiple linear regression models showed a negative association (P < 0.05) between alcohol and LDL cholesterol in men with the E2 allele but a positive association in men with the E4 allele. Alcohols 86-93 cystatin 12, pseudogene Homo sapiens 130-132 11273848-10 2001 Multiple linear regression models showed a negative association (P < 0.05) between alcohol and LDL cholesterol in men with the E2 allele but a positive association in men with the E4 allele. Cholesterol 102-113 cystatin 12, pseudogene Homo sapiens 130-132 11300910-2 2001 The rate-surfactant profiles for the HO(-)- and AcO(-)-catalyzed ring closure of two ethyl hydantoates, E2 and E3, to hydantoins with three cetyltrimethylammonium salts (CTAX, X = Br(-), Cl(-), or AcO(-)) are measured in 0.02 and 0.2 M acetate buffers 50% base with starting pH 4.65. Hydantoins 118-128 cystatin 12, pseudogene Homo sapiens 104-113 11300910-2 2001 The rate-surfactant profiles for the HO(-)- and AcO(-)-catalyzed ring closure of two ethyl hydantoates, E2 and E3, to hydantoins with three cetyltrimethylammonium salts (CTAX, X = Br(-), Cl(-), or AcO(-)) are measured in 0.02 and 0.2 M acetate buffers 50% base with starting pH 4.65. cetyltrimethylammonium salts 140-168 cystatin 12, pseudogene Homo sapiens 104-113 11300910-2 2001 The rate-surfactant profiles for the HO(-)- and AcO(-)-catalyzed ring closure of two ethyl hydantoates, E2 and E3, to hydantoins with three cetyltrimethylammonium salts (CTAX, X = Br(-), Cl(-), or AcO(-)) are measured in 0.02 and 0.2 M acetate buffers 50% base with starting pH 4.65. CAV protocol 48-51 cystatin 12, pseudogene Homo sapiens 104-113