PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
19454312-1	2009	AIM OF THE STUDY: Total flavonids of Polygonatum(P) odoratum (TFP) were tested for anti-diabetic activity in streptozotocin (STZ)-induced diabetic mice and alloxan-induced diabetic rats.	Streptozocin	109-123	tripartite motif-containing 39	Mus musculus	18-60
34644302-1	2021	Mitochondrial trifunctional protein (TFP) is a membrane-associated heterotetramer that catalyzes three of the four reactions needed to chain-shorten long-chain fatty acids inside the mitochondria.	Fatty Acids	160-171	tripartite motif-containing 39	Mus musculus	37-40
19454312-1	2009	AIM OF THE STUDY: Total flavonids of Polygonatum(P) odoratum (TFP) were tested for anti-diabetic activity in streptozotocin (STZ)-induced diabetic mice and alloxan-induced diabetic rats.	Streptozocin	125-128	tripartite motif-containing 39	Mus musculus	18-60
19454312-1	2009	AIM OF THE STUDY: Total flavonids of Polygonatum(P) odoratum (TFP) were tested for anti-diabetic activity in streptozotocin (STZ)-induced diabetic mice and alloxan-induced diabetic rats.	Alloxan	156-163	tripartite motif-containing 39	Mus musculus	18-60
19454312-3	2009	In our study, TFP was extracted by 70% ethanol and purified by macroreticular resin.	Ethanol	39-46	tripartite motif-containing 39	Mus musculus	14-17
19454312-4	2009	The experiments were designed to detect the anti-diabetic activity of TFP by determination of blood glucose (BG) using one touch gluco-meter and insulin levels by using a radioimmunoassay kit in streptozotocin (STZ)-induced diabetic mice and alloxan-induced diabetic rats and alpha-amylase inhibitory activity by alpha-amylase inhibition assay in vitro.	Blood Glucose	94-107	tripartite motif-containing 39	Mus musculus	70-73
19454312-4	2009	The experiments were designed to detect the anti-diabetic activity of TFP by determination of blood glucose (BG) using one touch gluco-meter and insulin levels by using a radioimmunoassay kit in streptozotocin (STZ)-induced diabetic mice and alloxan-induced diabetic rats and alpha-amylase inhibitory activity by alpha-amylase inhibition assay in vitro.	Streptozocin	211-214	tripartite motif-containing 39	Mus musculus	70-73
19454312-4	2009	The experiments were designed to detect the anti-diabetic activity of TFP by determination of blood glucose (BG) using one touch gluco-meter and insulin levels by using a radioimmunoassay kit in streptozotocin (STZ)-induced diabetic mice and alloxan-induced diabetic rats and alpha-amylase inhibitory activity by alpha-amylase inhibition assay in vitro.	Alloxan	242-249	tripartite motif-containing 39	Mus musculus	70-73
19454312-5	2009	RESULTS: TFP had beneficial effects on regulation of blood glucose.	Glucose	59-66	tripartite motif-containing 39	Mus musculus	9-12
19454312-6	2009	Daily administration with 50-200 mg/kg body weight of TFP for 9 days can reduce significantly hyperglycemia in STZ-induced diabetic mice.	Streptozocin	111-114	tripartite motif-containing 39	Mus musculus	54-57
19454312-7	2009	Thirtieth day administration with TFP (50-200 mg/kg body weight) also decreased significantly fasting blood glucose in alloxan-induced diabetic rats.	thirtieth	0-9	tripartite motif-containing 39	Mus musculus	34-37
19454312-7	2009	Thirtieth day administration with TFP (50-200 mg/kg body weight) also decreased significantly fasting blood glucose in alloxan-induced diabetic rats.	Glucose	108-115	tripartite motif-containing 39	Mus musculus	34-37
19454312-10	2009	TFP also could increase significantly the insulin level in alloxan-induced type 2 diabetic rats (P<0.05) compared with control.	Alloxan	59-66	tripartite motif-containing 39	Mus musculus	0-3
1674871-1	1991	The results from the present study using the sensitive and progressively DOX resistant L1210 model system demonstrated that the effects of TFP are not due to redistribution of DOX to the nucleus, and modulation of cytotoxicity is related to effects on DOX-induced DNA strand breaks.	Doxorubicin	73-76	tripartite motif-containing 39	Mus musculus	139-142
34644302-2	2021	TFP is known to be heavily modified by acetyllysine and succinyllysine post-translational modifications (PTMs), many of which are targeted for reversal by the mitochondrial sirtuin deacylases SIRT3 and SIRT5.	N-epsilon-Acetyl-L-lysine	39-51	tripartite motif-containing 39	Mus musculus	0-3
34644302-9	2021	However, the presence of liposomes strongly abrogated the acylation reaction between succinyl-CoA and TFP lysine residues.	succinyl-coenzyme A	85-97	tripartite motif-containing 39	Mus musculus	102-105
34644302-2	2021	TFP is known to be heavily modified by acetyllysine and succinyllysine post-translational modifications (PTMs), many of which are targeted for reversal by the mitochondrial sirtuin deacylases SIRT3 and SIRT5.	Succinyllysine	56-70	tripartite motif-containing 39	Mus musculus	0-3
34644302-9	2021	However, the presence of liposomes strongly abrogated the acylation reaction between succinyl-CoA and TFP lysine residues.	Lysine	106-112	tripartite motif-containing 39	Mus musculus	102-105
34644302-10	2021	Thus, TFP in the membrane-bound state may be protected against lysine acylation.	Lysine	63-69	tripartite motif-containing 39	Mus musculus	6-9
34644302-4	2021	Here, we mapped the known SIRT3/SIRT5-targeted lysine residues onto the recently solved TFP crystal structure which revealed that many of the target sites are involved in substrate channeling within the TFPalpha subunit.	Lysine	47-53	tripartite motif-containing 39	Mus musculus	88-91
24080545-3	2014	In this study, we demonstrate that the type IV pilus (Tfp) is important in the resistance of PA to the antibacterial effects of SP-A.	Protactinium	93-95	tripartite motif-containing 39	Mus musculus	54-57
35526824-12	2022	The mTFP based reporter assay showed decrease in the gene expression of mTFP in the TMPyP4 treated cells as compared to the untreated and further affirmed the formation of stable G-quadruplex structures in the HPGQ motifs in vivo.	tetra(4-N-methylpyridyl)porphine	84-90	tripartite motif-containing 39	Mus musculus	4-8
35526824-12	2022	The mTFP based reporter assay showed decrease in the gene expression of mTFP in the TMPyP4 treated cells as compared to the untreated and further affirmed the formation of stable G-quadruplex structures in the HPGQ motifs in vivo.	tetra(4-N-methylpyridyl)porphine	84-90	tripartite motif-containing 39	Mus musculus	72-76
2567212-1	1989	The effects of activators and inhibitors of protein kinase C (phorbol esters and H-7) and antagonist to calmodulin (TFP) on polyamine transport in murine leukemia (L1210) cells are investigated.	Polyamines	124-133	tripartite motif-containing 39	Mus musculus	116-119
6381970-10	1984	However, the liver glycogen levels in TFP plus endotoxin-treated mice were markedly higher than that in mice given endotoxin alone.	Glycogen	19-27	tripartite motif-containing 39	Mus musculus	38-41
29483294-2	2018	In Clostridium difficile, c-di-GMP negatively regulates flagellum biosynthesis and swimming motility and promotes the production of type IV pili (TFP), biofilm formation, and surface motility in vitro Flagella have been identified as colonization factors in C. difficile, but the role of TFP in adherence to host cells and in colonization of the mammalian gut is unknown.	bis(3',5')-cyclic diguanylic acid	26-34	tripartite motif-containing 39	Mus musculus	146-149
29483294-2	2018	In Clostridium difficile, c-di-GMP negatively regulates flagellum biosynthesis and swimming motility and promotes the production of type IV pili (TFP), biofilm formation, and surface motility in vitro Flagella have been identified as colonization factors in C. difficile, but the role of TFP in adherence to host cells and in colonization of the mammalian gut is unknown.	bis(3',5')-cyclic diguanylic acid	26-34	tripartite motif-containing 39	Mus musculus	288-291
29483294-4	2018	Using TFP-null mutants, we demonstrate that adherence to epithelial cells is partially mediated by TFP and that this TFP-mediated adherence requires c-di-GMP regulation.	bis(3',5')-cyclic diguanylic acid	149-157	tripartite motif-containing 39	Mus musculus	6-9
29483294-7	2018	Together these data indicate that TFP and their positive regulation by c-di-GMP promote attachment of C. difficile to the intestinal epithelium and contribute to persistence of C. difficile in the host intestine.	bis(3',5')-cyclic diguanylic acid	71-79	tripartite motif-containing 39	Mus musculus	34-37
19801409-1	2009	In Pseudomonas aeruginosa, cyclic AMP (cAMP) signaling regulates the transcription of hundreds of genes encoding diverse virulence factors, including the type II secretion system (T2SS) and type III secretion system (T3SS) and their associated toxins, type IV pili (TFP), and flagella.	Cyclic AMP	27-37	tripartite motif-containing 39	Mus musculus	266-269
24107297-4	2013	Two Tfp subunits, PilE and PilQ, are identified as the ligands for TNF-alpha and IL-8 in a glycan-dependent manner, and their deletion results in decreased virulence and increased survival in a mouse model.	Polysaccharides	91-97	tripartite motif-containing 39	Mus musculus	4-7
21646450-2	2011	We have recently shown that strains of C. perfringens move across the surface of agar plates by a unique type IV pilus (TFP)-mediated social motility that had not been previously described.	Agar	81-85	tripartite motif-containing 39	Mus musculus	120-123
23213260-4	2012	Moreover, although Trim39 loss inhibited etoposide-induced apoptosis in p53-negative cells, apoptosis was enhanced by Trim39 knockdown in p53-positive cells.	Etoposide	41-50	tripartite motif-containing 39	Mus musculus	19-25
22351764-4	2012	Inhibition of autolysosomal protein degradation by bafilomycin A(1) also increased Col-I protein levels and colocalization of Col-I with LC3, an autophagy marker, or LAMP-1, a lysosome marker, whereas treatment with TFP, an inducer of autophagy, resulted in decreased Col-I protein levels induced by TGF-beta1, without alterations in Col-I alpha1 mRNA.	bafilomycin A	51-64	tripartite motif-containing 39	Mus musculus	216-219
19801409-1	2009	In Pseudomonas aeruginosa, cyclic AMP (cAMP) signaling regulates the transcription of hundreds of genes encoding diverse virulence factors, including the type II secretion system (T2SS) and type III secretion system (T3SS) and their associated toxins, type IV pili (TFP), and flagella.	Cyclic AMP	39-43	tripartite motif-containing 39	Mus musculus	266-269