PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
15248753-3	2004	The Escherichia coli gene, codA, encodes cytosine deaminase and is introduced into cancer cells followed by administration of the prodrug 5-fluorocytosine (5-FC).	Flucytosine	138-154	plasmid maintenance protein CcdA	Escherichia coli	27-31
10080711-5	1999	As negative marker we used the Escherichia coli codA gene encoding cytosine deaminase, conferring upon the cells sensitivity to 5-flourocytosine (5-FC).	5-flourocytosine	128-144	plasmid maintenance protein CcdA	Escherichia coli	48-52
12700271-9	2003	K. pneumoniae differs from E. coli in having two cytosine deaminase genes, an intervening open reading frame between the codB and codA orthologs, and a different response to hypoxanthine which increased cod expression in K. pneumoniae but decreased it in E. coli.	Hypoxanthine	174-186	plasmid maintenance protein CcdA	Escherichia coli	130-134
26148515-5	2015	RESULTS: To prepare the deoxycytidine producing strain, we first deleted 3 degradation enzymes in the salvage pathway (deoA, udp, and deoD) and 4 enzymes involved in the branching pathway (dcd, cdd, codA and thyA) to completely eliminate degradation of deoxycytidine.	Deoxycytidine	24-37	plasmid maintenance protein CcdA	Escherichia coli	199-203
9785450-1	1998	The prodrug activation system formed by the E. coli codA gene encoding cytosine deaminase (CD) and 5-fluorocytosine (5-FC) developed for selective cancer chemotherapy suffers from a sensitivity limitation in many tumour cells.	Flucytosine	99-115	plasmid maintenance protein CcdA	Escherichia coli	52-56
9785450-1	1998	The prodrug activation system formed by the E. coli codA gene encoding cytosine deaminase (CD) and 5-fluorocytosine (5-FC) developed for selective cancer chemotherapy suffers from a sensitivity limitation in many tumour cells.	Flucytosine	117-121	plasmid maintenance protein CcdA	Escherichia coli	52-56
2673119-2	1989	Cytosine deaminase, encoded by the codA gene in Escherichia coli catalyzes the deamination of cytosine to uracil and ammonia.	Cytosine	94-102	plasmid maintenance protein CcdA	Escherichia coli	35-39
2673119-2	1989	Cytosine deaminase, encoded by the codA gene in Escherichia coli catalyzes the deamination of cytosine to uracil and ammonia.	Uracil	106-112	plasmid maintenance protein CcdA	Escherichia coli	35-39
2673119-2	1989	Cytosine deaminase, encoded by the codA gene in Escherichia coli catalyzes the deamination of cytosine to uracil and ammonia.	Ammonia	117-124	plasmid maintenance protein CcdA	Escherichia coli	35-39
2673119-5	1989	Derepression of codA expression was induced by starvation for either uracil or cytosine nucleotides.	Uracil	69-75	plasmid maintenance protein CcdA	Escherichia coli	16-20
2673119-5	1989	Derepression of codA expression was induced by starvation for either uracil or cytosine nucleotides.	Cytosine Nucleotides	79-99	plasmid maintenance protein CcdA	Escherichia coli	16-20
26090311-3	2015	The codA gene of Escherichia coli encodes cytosine deaminase that hydrolyzes 5-fluorocytosine (5-FC) into the cytotoxic compound 5 fluorouracil.	Flucytosine	77-93	plasmid maintenance protein CcdA	Escherichia coli	4-8
26090311-3	2015	The codA gene of Escherichia coli encodes cytosine deaminase that hydrolyzes 5-fluorocytosine (5-FC) into the cytotoxic compound 5 fluorouracil.	Fluorouracil	131-143	plasmid maintenance protein CcdA	Escherichia coli	4-8
25227763-2	2015	First, the translation rates of the expression module containing the Escherichia coli codA gene cloned under the control of the Pm promoter have been improved by using the T7 phage gene 10 ribosome binding site sequence and replacing the original GUG start codon by AUG. Second, to increase the time span in which cytosine deaminase may be produced by the bacteria in the presence of 5-fluorocytosine, a 5-fluorouracyl resistant Salmonella strain has been constructed by deleting its upp gene sequence.	Flucytosine	384-400	plasmid maintenance protein CcdA	Escherichia coli	86-90
25227763-2	2015	First, the translation rates of the expression module containing the Escherichia coli codA gene cloned under the control of the Pm promoter have been improved by using the T7 phage gene 10 ribosome binding site sequence and replacing the original GUG start codon by AUG. Second, to increase the time span in which cytosine deaminase may be produced by the bacteria in the presence of 5-fluorocytosine, a 5-fluorouracyl resistant Salmonella strain has been constructed by deleting its upp gene sequence.	5-fluorouracyl	404-418	plasmid maintenance protein CcdA	Escherichia coli	86-90
25234691-6	2014	We show that a codon-optimized variant of codA with three amino acid substitutions confers sensitivity to 5-fluorocytosine (5-FC) when expressed in the chloroplast under the control of endogenous promoter/5" UTR elements from the photosynthetic genes psaA or petA.	Flucytosine	108-122	plasmid maintenance protein CcdA	Escherichia coli	42-46
23955475-3	2013	We now developed a method based on counterselection by cytosine deaminase, encoded by the codA gene from Escherichia coli, in the presence of the fluorinated pyrimidine analogue 5-fluorocytosine (FC).	pyrimidine	158-168	plasmid maintenance protein CcdA	Escherichia coli	90-94
23955475-3	2013	We now developed a method based on counterselection by cytosine deaminase, encoded by the codA gene from Escherichia coli, in the presence of the fluorinated pyrimidine analogue 5-fluorocytosine (FC).	Flucytosine	178-194	plasmid maintenance protein CcdA	Escherichia coli	90-94
23955475-3	2013	We now developed a method based on counterselection by cytosine deaminase, encoded by the codA gene from Escherichia coli, in the presence of the fluorinated pyrimidine analogue 5-fluorocytosine (FC).	Flucytosine	196-198	plasmid maintenance protein CcdA	Escherichia coli	90-94
23955475-4	2013	The codA-encoded enzyme converts nontoxic FC to toxic 5-fluorouracil, which is channeled into the metabolism by the uracil phosphoribosyltransferase, encoded by the chromosomal upp gene of Gluconobacter.	Fluorouracil	54-68	plasmid maintenance protein CcdA	Escherichia coli	4-8