PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
28389464-3	2017	Through synthetic viability screening, we discovered that histone H4 K16 deacetylation drives the sensitivity of yeast cells to camptothecin and that inactivation of this pathway by mutating H4 K16 or the genes SIR1-4 suppresses much of the hypersensitivity of tof1  strains towards this agent.	Camptothecin	128-140	Sir1p	Saccharomyces cerevisiae S288C	211-215
15932939-2	2005	Here, we present the high-resolution crystal structures of the ORC interaction region (OIR) of Sir1p and that of the complex formed between the OIR and BAH domains.	bis(5-amidino-2-benzimidazolyl)methane ketone hydrate	152-155	Sir1p	Saccharomyces cerevisiae S288C	95-100
9872946-4	1999	The eight missense mutations all map within a 17-amino-acid segment of Sir1p, and this segment was also required for Sir1p"s interaction with Orc1p.	amino	49-54	Sir1p	Saccharomyces cerevisiae S288C	71-76
9872946-4	1999	The eight missense mutations all map within a 17-amino-acid segment of Sir1p, and this segment was also required for Sir1p"s interaction with Orc1p.	amino	49-54	Sir1p	Saccharomyces cerevisiae S288C	117-122
9753737-6	1998	However, two longer SIR1 transcripts were regulated reciprocally by carbon source.	Carbon	68-74	Sir1p	Saccharomyces cerevisiae S288C	20-24
28389464-4	2017	We show that disruption of rDNA or telomeric silencing does not mediate camptothecin resistance but that disruption of Sir1-dependent chromatin domains is sufficient to suppress camptothecin sensitivity in wild-type and tof1  cells.	Camptothecin	178-190	Sir1p	Saccharomyces cerevisiae S288C	119-123
27074556-3	2016	Ethanol-induced reactive oxygen species (ROS) and superoxide signals promoted growth rate during passages that was accompanied by increased expression of sirtuin proteins, Sir1, Sir2 and Sir3, and DNA-binding transcription regulator Rap1.	Ethanol	0-7	Sir1p	Saccharomyces cerevisiae S288C	172-176
27074556-3	2016	Ethanol-induced reactive oxygen species (ROS) and superoxide signals promoted growth rate during passages that was accompanied by increased expression of sirtuin proteins, Sir1, Sir2 and Sir3, and DNA-binding transcription regulator Rap1.	Superoxides	50-60	Sir1p	Saccharomyces cerevisiae S288C	172-176
19171939-10	2009	We propose that the functional specialization of Sir3, itself a paralog of Orc1, as a silencing protein was facilitated by the tandem duplication of the OIR domain in the Sir1 family, allowing distinct Sir1-Sir3 and Sir1-Orc1 interactions through OIR-BAH domain interactions.	bis(5-amidino-2-benzimidazolyl)methane ketone hydrate	251-254	Sir1p	Saccharomyces cerevisiae S288C	171-175
19171939-10	2009	We propose that the functional specialization of Sir3, itself a paralog of Orc1, as a silencing protein was facilitated by the tandem duplication of the OIR domain in the Sir1 family, allowing distinct Sir1-Sir3 and Sir1-Orc1 interactions through OIR-BAH domain interactions.	bis(5-amidino-2-benzimidazolyl)methane ketone hydrate	251-254	Sir1p	Saccharomyces cerevisiae S288C	202-206
19171939-10	2009	We propose that the functional specialization of Sir3, itself a paralog of Orc1, as a silencing protein was facilitated by the tandem duplication of the OIR domain in the Sir1 family, allowing distinct Sir1-Sir3 and Sir1-Orc1 interactions through OIR-BAH domain interactions.	bis(5-amidino-2-benzimidazolyl)methane ketone hydrate	251-254	Sir1p	Saccharomyces cerevisiae S288C	202-206