PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23435447-1	2013	UNLABELLED: Deficiency of 17beta-hydroxysteroid dehydrogenase type 3 (17betaHSD3), an enzyme converting androstenedione (A) to testosterone (T), is a rare cause of autosomal recessive 46,XY disorder of sexual development (DSD).	Androstenedione	104-119	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	26-80
25298885-2	2014	The enzyme 17beta-hydroxysteroid-dehydrogenase type 3 (17betaHSD3) is present almost exclusively in the testicles and converts Delta 4-androstenodione (Delta4) to testosterone.	delta 4-androstenodione	127-150	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	11-65
25298885-2	2014	The enzyme 17beta-hydroxysteroid-dehydrogenase type 3 (17betaHSD3) is present almost exclusively in the testicles and converts Delta 4-androstenodione (Delta4) to testosterone.	Testosterone	163-175	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	11-65
23881245-3	2013	Human HSD11B1L, which was characterized as a unidirectional NADP(+)-dependent cortisol dehydrogenase, appears to be specifically expressed in the brain.	NADP	60-67	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	6-14
23435447-1	2013	UNLABELLED: Deficiency of 17beta-hydroxysteroid dehydrogenase type 3 (17betaHSD3), an enzyme converting androstenedione (A) to testosterone (T), is a rare cause of autosomal recessive 46,XY disorder of sexual development (DSD).	Testosterone	127-139	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	26-80
22512907-1	2012	We have previously reported the discovery of a new class of potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) derived from benzylidene oxazolidinedione and thiazolidinedione scaffolds.	benzylidene oxazolidinedione	151-179	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	81-136
23132791-4	2013	It inhibits adione-stimulated proliferation of 17beta-HSD3-expressing androgen receptor-positive LNCaP(HSD3) prostate cancer cells in vitro.	Androstenedione	12-18	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	54-58
22512907-1	2012	We have previously reported the discovery of a new class of potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) derived from benzylidene oxazolidinedione and thiazolidinedione scaffolds.	2,4-thiazolidinedione	184-201	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	81-136
19436836-10	2009	SCDR10B can catalyze the dehydrogenation of cortisol in the presence of NADP(+), and therefore it is a hydroxysteroid dehydrogenase.	Hydrocortisone	44-52	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	0-7
22137341-1	2012	Novel and potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) were identified based on oxazolidinedione and thiazolidinedione derivatives, starting from a high-throughput screening hit, 5-(3-bromo-4-hydroxybenzyl)-3-(4-methoxyphenyl)-1,3-thiazol-2-one.	2,4-thiazolidinedione	134-151	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	31-86
22137341-1	2012	Novel and potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) were identified based on oxazolidinedione and thiazolidinedione derivatives, starting from a high-throughput screening hit, 5-(3-bromo-4-hydroxybenzyl)-3-(4-methoxyphenyl)-1,3-thiazol-2-one.	5-(3-bromo-4-hydroxybenzyl)-3-(4-methoxyphenyl)-1,3-thiazol-2-one	212-277	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	31-86
21300150-1	2011	17beta-Hydroxysteroid dehydrogenase type 3 and 5 (17beta-HSD3 and 17beta-HSD5) catalyze testosterone biosynthesis and thereby constitute therapeutic targets for androgen-related diseases or endocrine-disrupting chemicals.	Testosterone	88-100	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	0-61
20005209-4	2010	The database was screened using pharmacophores of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3), which catalyzes the last step of testosterone synthesis in testicular Leydig cells and plays an essential role during male sexual development.	Testosterone	141-153	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	50-105
18775469-1	2009	17beta-Hydroxysteroid dehydrogenase type 3 (17beta-HSD3) is expressed at high levels in the testes and seminal vesicles but has also been shown to be present in prostate tissue, suggesting its potential involvement in both gonadal and non-gonadal testosterone biosynthesis.	Testosterone	247-259	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	0-55
21741247-1	2011	17Beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) is a steroidogenic enzyme that catalyzes the transformation of 4-androstene-3,17-dione (Delta4-dione) into androgen testosterone (T).	Androstenedione	120-143	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	0-55
21741247-1	2011	17Beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) is a steroidogenic enzyme that catalyzes the transformation of 4-androstene-3,17-dione (Delta4-dione) into androgen testosterone (T).	Testosterone	173-185	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	0-55
18786604-9	2009	Adione-stimulated proliferation of LNCaP[17beta-HSD3] cells was inhibited in the presence of either STX2171 or STX2624.	Androstenedione	0-6	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	35-52
19436836-10	2009	SCDR10B can catalyze the dehydrogenation of cortisol in the presence of NADP(+), and therefore it is a hydroxysteroid dehydrogenase.	NADP	72-79	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	0-7
26277760-1	2015	17beta-Hydroxysteroid dehydrogenase type 3 (17beta-HSD3) is a key enzyme involved in the biosynthesis of testosterone and dihydrotestosterone.	Testosterone	105-117	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	0-55
28182747-1	2017	In the fight against androgen-sensitive prostate cancer, the enzyme 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) is an attractive therapeutic target considering its key role in the formation of androgenic steroids.	Steroids	217-225	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	68-123
17466011-1	2007	OBJECTIVE: 17beta-hydroxysteroid dehydrogenase type 3 isoenzyme (17beta-HSD3) is required to produce testosterone for male sex differentiation.	Testosterone	101-113	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	11-76
16797984-0	2006	Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-hydroxyphenyl ketones as potential inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3).	4-hydroxyphenyl ketones	96-119	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	147-202
15924334-2	2005	METHODS: In an effort to evaluate new therapies which could inhibit gonadal or non-gonadal testosterone biosynthesis, we developed high throughput biochemical and cellular screening assays to identify inhibitors of 17beta-hydroxysteroid dehydrogenase type III (17beta-HSD3), the enzyme catalyzing the conversion of androstenedione (AdT) to testosterone.	Testosterone	91-103	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	215-272
15924334-2	2005	METHODS: In an effort to evaluate new therapies which could inhibit gonadal or non-gonadal testosterone biosynthesis, we developed high throughput biochemical and cellular screening assays to identify inhibitors of 17beta-hydroxysteroid dehydrogenase type III (17beta-HSD3), the enzyme catalyzing the conversion of androstenedione (AdT) to testosterone.	Androstenedione	315-330	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	215-272
15924334-2	2005	METHODS: In an effort to evaluate new therapies which could inhibit gonadal or non-gonadal testosterone biosynthesis, we developed high throughput biochemical and cellular screening assays to identify inhibitors of 17beta-hydroxysteroid dehydrogenase type III (17beta-HSD3), the enzyme catalyzing the conversion of androstenedione (AdT) to testosterone.	Androstenedione	332-335	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	215-272
15924334-2	2005	METHODS: In an effort to evaluate new therapies which could inhibit gonadal or non-gonadal testosterone biosynthesis, we developed high throughput biochemical and cellular screening assays to identify inhibitors of 17beta-hydroxysteroid dehydrogenase type III (17beta-HSD3), the enzyme catalyzing the conversion of androstenedione (AdT) to testosterone.	Testosterone	340-352	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	215-272
15745934-4	2005	Due to an increased basal serum ratio of androstenedione/testosterone, 17 beta-hydroxysteroid dehydrogenase type 3 (17 beta-HSD 3) deficiency was initially suspected.	Androstenedione	41-56	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	71-129
15745934-4	2005	Due to an increased basal serum ratio of androstenedione/testosterone, 17 beta-hydroxysteroid dehydrogenase type 3 (17 beta-HSD 3) deficiency was initially suspected.	Testosterone	57-69	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	71-129
28774765-1	2017	17beta-Hydroxysteroid dehydrogenase type 3 (17beta-HSD3) converts the inactive Delta4-androstenedione (A) to testosterone (T).	Testosterone	109-121	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	0-55
28267564-1	2017	17beta-Hydroxysteroid dehydrogenase type 3 (17beta-HSD3) is expressed almost exclusively in the testes and specifically converts the weak androgenic androstenedione to active testosterone (T) in the presence of NADPH.	Androstenedione	149-164	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	0-55
28267564-1	2017	17beta-Hydroxysteroid dehydrogenase type 3 (17beta-HSD3) is expressed almost exclusively in the testes and specifically converts the weak androgenic androstenedione to active testosterone (T) in the presence of NADPH.	Testosterone	175-187	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	0-55
28254377-1	2017	17beta-Hydroxysteroid dehydrogenase type 3 (17beta-HSD3) is a major player in human endocrinology, being one of the most important enzymes involved in testosterone production.	Testosterone	151-163	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	0-55
26956191-1	2017	17beta-Hydroxysteroid dehydrogenase type 3 (17beta-HSD3) is expressed almost exclusively in the testis and converts Delta4-androstene-3,17-dione to testosterone.	Testosterone	148-160	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	0-55
26277760-1	2015	17beta-Hydroxysteroid dehydrogenase type 3 (17beta-HSD3) is a key enzyme involved in the biosynthesis of testosterone and dihydrotestosterone.	Dihydrotestosterone	122-141	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	0-55
25064799-1	2015	Deficiency of 17beta-hydroxysteroid dehydrogenase type3 (17beta-HSD3) isoenzyme which catalyzes the synthesis of testosterone from Delta4-androstenedione, is the cause of 46, XY disorders of sex development (DSD).	Testosterone	113-125	hydroxysteroid 11-beta dehydrogenase 1 like	Homo sapiens	14-68