PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
12783875-9	2003	Metabolic labeling studies showed that overexpression of maCER1 caused a decrease in the incorporation of radiolabeled dihydrosphingosine into ceramide and complex sphingolipids but led to a concomitant increase in sphingosine-1-P (S1P) in HeLa cells.	safingol	119-137	alkaline ceramidase 1	Mus musculus	57-63
29056331-2	2017	With a mouse model deficient in the alkaline ceramidase (Acer1) gene, we demonstrate that ACER1 plays a key role in the homeostasis of the epidermis and its appendages by controlling the metabolism of ceramides.	Ceramides	201-210	alkaline ceramidase 1	Mus musculus	57-62
29056331-2	2017	With a mouse model deficient in the alkaline ceramidase (Acer1) gene, we demonstrate that ACER1 plays a key role in the homeostasis of the epidermis and its appendages by controlling the metabolism of ceramides.	Ceramides	201-210	alkaline ceramidase 1	Mus musculus	90-95
29056331-3	2017	Loss of Acer1 elevated the levels of various ceramides and sphingoid bases in the skin and caused progressive hair loss in mice.	Ceramides	45-54	alkaline ceramidase 1	Mus musculus	8-13
29056331-3	2017	Loss of Acer1 elevated the levels of various ceramides and sphingoid bases in the skin and caused progressive hair loss in mice.	sphingoid bases	59-74	alkaline ceramidase 1	Mus musculus	8-13
29056331-5	2017	These results suggest that ACER1 plays a key role in maintaining the homeostasis of HFSCs, and thereby the hair follicle structure and function, by regulating the metabolism of ceramides in the epidermis.	Ceramides	177-186	alkaline ceramidase 1	Mus musculus	27-32
27126290-4	2016	Acer1-deficient (Acer1(-/-) ) mice showed elevated levels of ceramide in the skin, aberrant hair shaft cuticle formation and cyclic alopecia.	Ceramides	61-69	alkaline ceramidase 1	Mus musculus	17-27
12783875-6	2003	In vitro biochemical characterization determined that maCER1 hydrolyzed D-erythro-ceramide exclusively but not D-erythro-dihydroceramide or D-ribo-phytoceramide.	d-erythro-ceramide	72-90	alkaline ceramidase 1	Mus musculus	54-60
12783875-7	2003	Similar to other alkaline ceramidases, maCER1 had an alkaline pH optimum of 8.0, and it was activated by Ca2+ but inhibited by Zn2+,Cu2+, and Mn2+.	Zinc	127-131	alkaline ceramidase 1	Mus musculus	39-45
12783875-9	2003	Metabolic labeling studies showed that overexpression of maCER1 caused a decrease in the incorporation of radiolabeled dihydrosphingosine into ceramide and complex sphingolipids but led to a concomitant increase in sphingosine-1-P (S1P) in HeLa cells.	Ceramides	143-151	alkaline ceramidase 1	Mus musculus	57-63
12783875-7	2003	Similar to other alkaline ceramidases, maCER1 had an alkaline pH optimum of 8.0, and it was activated by Ca2+ but inhibited by Zn2+,Cu2+, and Mn2+.	cupric ion	132-136	alkaline ceramidase 1	Mus musculus	39-45
12783875-9	2003	Metabolic labeling studies showed that overexpression of maCER1 caused a decrease in the incorporation of radiolabeled dihydrosphingosine into ceramide and complex sphingolipids but led to a concomitant increase in sphingosine-1-P (S1P) in HeLa cells.	Sphingolipids	164-177	alkaline ceramidase 1	Mus musculus	57-63
12783875-7	2003	Similar to other alkaline ceramidases, maCER1 had an alkaline pH optimum of 8.0, and it was activated by Ca2+ but inhibited by Zn2+,Cu2+, and Mn2+.	Manganese(2+)	142-146	alkaline ceramidase 1	Mus musculus	39-45
12783875-10	2003	Mass measurement showed that overexpression of maCER1 selectively lowered the cellular levels of D-erythro-C24:1-ceramide, but not other ceramide species and caused an increase in the levels of S1P.	d-erythro-c24:1-ceramide	97-121	alkaline ceramidase 1	Mus musculus	47-53
12783875-8	2003	maCER1 was also inhibited by sphingosine, one of its products.	Sphingosine	29-40	alkaline ceramidase 1	Mus musculus	0-6
12783875-10	2003	Mass measurement showed that overexpression of maCER1 selectively lowered the cellular levels of D-erythro-C24:1-ceramide, but not other ceramide species and caused an increase in the levels of S1P.	Ceramides	113-121	alkaline ceramidase 1	Mus musculus	47-53
12783875-11	2003	Taken together, these data suggest that maCER1 is a novel alkaline ceramidase with a stringent substrate specificity and that maCER1 is selectively expressed in skin and may have a role in regulating the levels of bioactive lipids ceramide and S1P, as well as complex sphingolipids.	Ceramides	231-239	alkaline ceramidase 1	Mus musculus	40-46
12783875-11	2003	Taken together, these data suggest that maCER1 is a novel alkaline ceramidase with a stringent substrate specificity and that maCER1 is selectively expressed in skin and may have a role in regulating the levels of bioactive lipids ceramide and S1P, as well as complex sphingolipids.	Ceramides	231-239	alkaline ceramidase 1	Mus musculus	126-132
12783875-11	2003	Taken together, these data suggest that maCER1 is a novel alkaline ceramidase with a stringent substrate specificity and that maCER1 is selectively expressed in skin and may have a role in regulating the levels of bioactive lipids ceramide and S1P, as well as complex sphingolipids.	Sphingolipids	268-281	alkaline ceramidase 1	Mus musculus	40-46
12783875-11	2003	Taken together, these data suggest that maCER1 is a novel alkaline ceramidase with a stringent substrate specificity and that maCER1 is selectively expressed in skin and may have a role in regulating the levels of bioactive lipids ceramide and S1P, as well as complex sphingolipids.	Sphingolipids	268-281	alkaline ceramidase 1	Mus musculus	126-132
35063864-6	2022	We showed that COS significantly suppressed the abnormal expression of these genes, including ceramide glucosyltransferase (CGT), sphingolipid 4-desaturase (DEGS2), alkaline ceramidase (ACER1), sphingosine kinase 2 (SPHK2), lysophosphatidylcholine acyltransferase (LPCAT1), and aromatic-L-amino-acid (DDC).	carbonyl sulfide	15-18	alkaline ceramidase 1	Mus musculus	186-191