PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34817067-0	2022	The S-adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening.	sinefungin	32-42	trimethylguanosine synthase 1	Homo sapiens	56-83
18039666-6	2008	We also show that production of the short Tgs1 isoform is inhibited by MG132, suggesting that it results from proteasomal limited processing of the full-length Tgs1 protein.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	71-76	trimethylguanosine synthase 1	Homo sapiens	42-46
18039666-6	2008	We also show that production of the short Tgs1 isoform is inhibited by MG132, suggesting that it results from proteasomal limited processing of the full-length Tgs1 protein.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	71-76	trimethylguanosine synthase 1	Homo sapiens	160-164
34817067-0	2022	The S-adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening.	sinefungin	32-42	trimethylguanosine synthase 1	Homo sapiens	84-88
34817067-4	2022	Here, we show that treatment with the S-adenosylmethionine analog sinefungin inhibits TGS1 activity, increases the hTR levels and promotes telomere lengthening in different cell types.	sinefungin	66-76	trimethylguanosine synthase 1	Homo sapiens	86-90
29527542-5	2018	Indeed, we have identified a group of pri-miRNAs (whose mature miRNAs were found induced during quiescence) modified with a 2,2,7-trimethylguanosine (TMG)-cap by the trimethylguanosine synthase 1 (TGS1) protein and transported to the cytoplasm by the Exportin-1 (XPO1) protein.	N(2),N(2),7-trimethylguanosine	124-148	trimethylguanosine synthase 1	Homo sapiens	166-195
35484160-0	2022	TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance.	N(2),N(2),7-trimethylguanosine	14-39	trimethylguanosine synthase 1	Homo sapiens	0-4
35484160-2	2022	Using human lung cancer cells and tumor organoids we show that formation of the 2,2,7-trimethylguanosine (TMG) cap structure at the human telomerase RNA 5" end by the Trimethylguanosine Synthase 1 (TGS1) is central for recruiting telomerase to telomeres and engaging Cajal bodies in telomere maintenance.	N(2),N(2),7-trimethylguanosine	80-104	trimethylguanosine synthase 1	Homo sapiens	167-196
35484160-2	2022	Using human lung cancer cells and tumor organoids we show that formation of the 2,2,7-trimethylguanosine (TMG) cap structure at the human telomerase RNA 5" end by the Trimethylguanosine Synthase 1 (TGS1) is central for recruiting telomerase to telomeres and engaging Cajal bodies in telomere maintenance.	N(2),N(2),7-trimethylguanosine	80-104	trimethylguanosine synthase 1	Homo sapiens	198-202
35484160-2	2022	Using human lung cancer cells and tumor organoids we show that formation of the 2,2,7-trimethylguanosine (TMG) cap structure at the human telomerase RNA 5" end by the Trimethylguanosine Synthase 1 (TGS1) is central for recruiting telomerase to telomeres and engaging Cajal bodies in telomere maintenance.	N(2),N(2),7-trimethylguanosine	106-109	trimethylguanosine synthase 1	Homo sapiens	167-196
35484160-2	2022	Using human lung cancer cells and tumor organoids we show that formation of the 2,2,7-trimethylguanosine (TMG) cap structure at the human telomerase RNA 5" end by the Trimethylguanosine Synthase 1 (TGS1) is central for recruiting telomerase to telomeres and engaging Cajal bodies in telomere maintenance.	N(2),N(2),7-trimethylguanosine	106-109	trimethylguanosine synthase 1	Homo sapiens	198-202
35484160-3	2022	TGS1 depletion or inhibition by the natural nucleoside sinefungin impairs telomerase recruitment to telomeres leading to Exonuclease 1 mediated generation of telomere 3" end protrusions that engage in RAD51-dependent, homology directed recombination and the activation of key features of the ALT pathway.	sinefungin	55-65	trimethylguanosine synthase 1	Homo sapiens	0-4
29527542-5	2018	Indeed, we have identified a group of pri-miRNAs (whose mature miRNAs were found induced during quiescence) modified with a 2,2,7-trimethylguanosine (TMG)-cap by the trimethylguanosine synthase 1 (TGS1) protein and transported to the cytoplasm by the Exportin-1 (XPO1) protein.	N(2),N(2),7-trimethylguanosine	124-148	trimethylguanosine synthase 1	Homo sapiens	197-201
29527542-5	2018	Indeed, we have identified a group of pri-miRNAs (whose mature miRNAs were found induced during quiescence) modified with a 2,2,7-trimethylguanosine (TMG)-cap by the trimethylguanosine synthase 1 (TGS1) protein and transported to the cytoplasm by the Exportin-1 (XPO1) protein.	N(2),N(2),7-trimethylguanosine	150-153	trimethylguanosine synthase 1	Homo sapiens	166-195
29527542-5	2018	Indeed, we have identified a group of pri-miRNAs (whose mature miRNAs were found induced during quiescence) modified with a 2,2,7-trimethylguanosine (TMG)-cap by the trimethylguanosine synthase 1 (TGS1) protein and transported to the cytoplasm by the Exportin-1 (XPO1) protein.	N(2),N(2),7-trimethylguanosine	150-153	trimethylguanosine synthase 1	Homo sapiens	197-201
27236791-3	2016	A trimethylguanosine synthase was engineered to introduce alkyne, azido, or 4-vinylbenzyl moieties to the 5"-cap.	Alkynes	58-64	trimethylguanosine synthase 1	Homo sapiens	2-29
28584122-4	2017	Moreover, these quiescence-induced primary miRNAs (pri-miRNAs) are modified with a 2,2,7-trimethylguanosine (TMG)-cap, which is known to bind Exportin-1, and knockdown of Exportin-1 or trimethylguanosine synthase 1, responsible for (TMG)-capping, inhibits their biogenesis.	N(2),N(2),7-trimethylguanosine	109-112	trimethylguanosine synthase 1	Homo sapiens	185-214
27236791-3	2016	A trimethylguanosine synthase was engineered to introduce alkyne, azido, or 4-vinylbenzyl moieties to the 5"-cap.	3',5-diazido-2',3'-dideoxyuridine	66-71	trimethylguanosine synthase 1	Homo sapiens	2-29
27236791-3	2016	A trimethylguanosine synthase was engineered to introduce alkyne, azido, or 4-vinylbenzyl moieties to the 5"-cap.	4-vinylbenzyl	76-89	trimethylguanosine synthase 1	Homo sapiens	2-29
24664183-2	2014	A trimethylguanosine synthase was engineered to transfer a terminal azido moiety to the 5"-cap which could be further modified using strain-promoted azide-alkyne cycloaddition (SPAAC).	3',5-diazido-2',3'-dideoxyuridine	68-73	trimethylguanosine synthase 1	Homo sapiens	2-29
26074133-1	2015	Trimethylguanosine Synthase catalyses transfer of two methyl groups to the m(7)G cap of RNA polymerase II transcribed snRNAs, snoRNAs, and telomerase RNA TLC1 to form a 2,2,7-trimethylguanosine cap.	N(2),N(2),7-trimethylguanosine	169-193	trimethylguanosine synthase 1	Homo sapiens	0-27
24664183-2	2014	A trimethylguanosine synthase was engineered to transfer a terminal azido moiety to the 5"-cap which could be further modified using strain-promoted azide-alkyne cycloaddition (SPAAC).	Azides	149-154	trimethylguanosine synthase 1	Homo sapiens	2-29
24664183-2	2014	A trimethylguanosine synthase was engineered to transfer a terminal azido moiety to the 5"-cap which could be further modified using strain-promoted azide-alkyne cycloaddition (SPAAC).	Alkynes	155-161	trimethylguanosine synthase 1	Homo sapiens	2-29
24664183-2	2014	A trimethylguanosine synthase was engineered to transfer a terminal azido moiety to the 5"-cap which could be further modified using strain-promoted azide-alkyne cycloaddition (SPAAC).	spaac	177-182	trimethylguanosine synthase 1	Homo sapiens	2-29
20360394-1	2010	Yeast and human Tgs1 are orthologous RNA cap (guanine-N2) methyltransferases that convert m(7)G caps into the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal snRNAs.	N(2),N(2),7-trimethylguanosine	110-134	trimethylguanosine synthase 1	Homo sapiens	16-20
20360394-1	2010	Yeast and human Tgs1 are orthologous RNA cap (guanine-N2) methyltransferases that convert m(7)G caps into the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal snRNAs.	N(2),N(2),7-trimethylguanosine	136-139	trimethylguanosine synthase 1	Homo sapiens	16-20
19386620-2	2009	The Trimethylguanosine Synthase 1 (TGS1) mediates this conversion of the 7-methylguanosine-cap to the 2,2,7-trimethylguanosine (m(3)G)-cap during maturation of the RNPs.	7-methylguanosine	73-90	trimethylguanosine synthase 1	Homo sapiens	4-33
19926722-5	2010	hTgs1 utilizes a broad range of m(7)G nucleotides, including mono-, di-, tri-, and tetraphosphate derivatives as well as cap dinucleotides with triphosphate or tetraphosphate bridges.	mono-, di-, tri-, and tetraphosphate	61-97	trimethylguanosine synthase 1	Homo sapiens	0-5
19926722-5	2010	hTgs1 utilizes a broad range of m(7)G nucleotides, including mono-, di-, tri-, and tetraphosphate derivatives as well as cap dinucleotides with triphosphate or tetraphosphate bridges.	Dinucleoside Phosphates	125-138	trimethylguanosine synthase 1	Homo sapiens	0-5
19926722-5	2010	hTgs1 utilizes a broad range of m(7)G nucleotides, including mono-, di-, tri-, and tetraphosphate derivatives as well as cap dinucleotides with triphosphate or tetraphosphate bridges.	triphosphoric acid	144-156	trimethylguanosine synthase 1	Homo sapiens	0-5
19926722-5	2010	hTgs1 utilizes a broad range of m(7)G nucleotides, including mono-, di-, tri-, and tetraphosphate derivatives as well as cap dinucleotides with triphosphate or tetraphosphate bridges.	tetraphosphate	83-97	trimethylguanosine synthase 1	Homo sapiens	0-5
19926722-7	2010	Methylation of benzyl(7)G and ethyl(7)G nucleotides by hTgs1 and GlaTgs2 underscored the importance of guanine N7 alkylation in providing a key pi-cation interaction in the methyl acceptor site.	Guanine	103-110	trimethylguanosine synthase 1	Homo sapiens	55-60
19386620-2	2009	The Trimethylguanosine Synthase 1 (TGS1) mediates this conversion of the 7-methylguanosine-cap to the 2,2,7-trimethylguanosine (m(3)G)-cap during maturation of the RNPs.	7-methylguanosine	73-90	trimethylguanosine synthase 1	Homo sapiens	35-39
19386620-2	2009	The Trimethylguanosine Synthase 1 (TGS1) mediates this conversion of the 7-methylguanosine-cap to the 2,2,7-trimethylguanosine (m(3)G)-cap during maturation of the RNPs.	N(2),N(2),7-trimethylguanosine	102-126	trimethylguanosine synthase 1	Homo sapiens	4-33
19386620-2	2009	The Trimethylguanosine Synthase 1 (TGS1) mediates this conversion of the 7-methylguanosine-cap to the 2,2,7-trimethylguanosine (m(3)G)-cap during maturation of the RNPs.	N(2),N(2),7-trimethylguanosine	102-126	trimethylguanosine synthase 1	Homo sapiens	35-39
19386620-4	2009	In order to understand the structural organization of human TGS1 as well as substrate binding and recognition we solved the crystal structure of the active TGS1 methyltransferase domain containing both, the minimal substrate m(7)GTP and the reaction product S-adenosyl-L-homocysteine (AdoHcy).	(7)gtp	226-232	trimethylguanosine synthase 1	Homo sapiens	60-64
19386620-4	2009	In order to understand the structural organization of human TGS1 as well as substrate binding and recognition we solved the crystal structure of the active TGS1 methyltransferase domain containing both, the minimal substrate m(7)GTP and the reaction product S-adenosyl-L-homocysteine (AdoHcy).	(7)gtp	226-232	trimethylguanosine synthase 1	Homo sapiens	156-160
19386620-4	2009	In order to understand the structural organization of human TGS1 as well as substrate binding and recognition we solved the crystal structure of the active TGS1 methyltransferase domain containing both, the minimal substrate m(7)GTP and the reaction product S-adenosyl-L-homocysteine (AdoHcy).	Sulfur	62-63	trimethylguanosine synthase 1	Homo sapiens	156-160
19386620-4	2009	In order to understand the structural organization of human TGS1 as well as substrate binding and recognition we solved the crystal structure of the active TGS1 methyltransferase domain containing both, the minimal substrate m(7)GTP and the reaction product S-adenosyl-L-homocysteine (AdoHcy).	S-Adenosylhomocysteine	260-283	trimethylguanosine synthase 1	Homo sapiens	156-160
19386620-4	2009	In order to understand the structural organization of human TGS1 as well as substrate binding and recognition we solved the crystal structure of the active TGS1 methyltransferase domain containing both, the minimal substrate m(7)GTP and the reaction product S-adenosyl-L-homocysteine (AdoHcy).	S-Adenosylhomocysteine	285-291	trimethylguanosine synthase 1	Homo sapiens	156-160
18775984-0	2008	Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways.	N(2),N(2),7-trimethylguanosine	107-131	trimethylguanosine synthase 1	Homo sapiens	56-83
18775984-1	2008	Trimethylguanosine synthase (Tgs1) is the enzyme that converts standard m(7)G caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal small nuclear RNAs.	N(2),N(2),7-trimethylguanosine	90-114	trimethylguanosine synthase 1	Homo sapiens	0-27
18775984-1	2008	Trimethylguanosine synthase (Tgs1) is the enzyme that converts standard m(7)G caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal small nuclear RNAs.	N(2),N(2),7-trimethylguanosine	90-114	trimethylguanosine synthase 1	Homo sapiens	29-33
18775984-1	2008	Trimethylguanosine synthase (Tgs1) is the enzyme that converts standard m(7)G caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal small nuclear RNAs.	N(2),N(2),7-trimethylguanosine	116-119	trimethylguanosine synthase 1	Homo sapiens	0-27
18775984-1	2008	Trimethylguanosine synthase (Tgs1) is the enzyme that converts standard m(7)G caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal small nuclear RNAs.	N(2),N(2),7-trimethylguanosine	116-119	trimethylguanosine synthase 1	Homo sapiens	29-33