PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
1826753-5	1991	Morphine (4 mg/kg, s.c.) administered 30 min prior completely blocked the response produced by ET-1.	Morphine	0-8	endothelin 1	Mus musculus	95-99
1826753-7	1991	The effect of big-ET-1[1-38], but not ET-1, was blocked by pretreatment with the enzyme inhibitor phosphoramidon (10 mg/kg, s.c., 30 min prior), implying that the big-ET-1[1-38] must first be enzymatically cleaved, presumably to ET-1, in order to elicit the abdominal constriction response.	phosphoramidon	98-112	endothelin 1	Mus musculus	18-22
2274119-0	1990	Effect of endothelins on cytosolic free calcium concentration in neuroblastoma NG108-15 and NCB-20 cells.	Calcium	40-47	endothelin 1	Mus musculus	10-21
1963807-2	1990	The vasoconstrictor peptide endothelin-1 caused a fast, transient rise in guanosine 3":5"-cyclic monophosphate (cyclic GMP) levels in a neuronal cell line (mouse neuroblastoma x rat glioma hybrid cells 108CC15).	Cyclic GMP	74-110	endothelin 1	Mus musculus	28-40
1875787-6	1991	The antagonism of ET-1-induced abdominal constriction by morphine was blocked by naloxone (1.0 mg/kg, s.c.) or by 24 h pretreatment with beta-funaltrexamine (beta-FNA; 8.84 micrograms, i.c.v.).	Morphine	57-65	endothelin 1	Mus musculus	18-22
1875787-6	1991	The antagonism of ET-1-induced abdominal constriction by morphine was blocked by naloxone (1.0 mg/kg, s.c.) or by 24 h pretreatment with beta-funaltrexamine (beta-FNA; 8.84 micrograms, i.c.v.).	Naloxone	81-89	endothelin 1	Mus musculus	18-22
1875787-6	1991	The antagonism of ET-1-induced abdominal constriction by morphine was blocked by naloxone (1.0 mg/kg, s.c.) or by 24 h pretreatment with beta-funaltrexamine (beta-FNA; 8.84 micrograms, i.c.v.).	beta-funaltrexamine	137-156	endothelin 1	Mus musculus	18-22
1875787-6	1991	The antagonism of ET-1-induced abdominal constriction by morphine was blocked by naloxone (1.0 mg/kg, s.c.) or by 24 h pretreatment with beta-funaltrexamine (beta-FNA; 8.84 micrograms, i.c.v.).	beta-funaltrexamine	158-166	endothelin 1	Mus musculus	18-22
32858189-7	2020	Overexpressed ET-1 promoted p16INK4a-positive senescent chondrocytes accumulation and cartilage degradation in TET-1 mice.	tetramethylenedisulfotetramine	111-114	endothelin 1	Mus musculus	14-18
2155611-1	1990	Vasoactive intestinal contractor peptide (VIC), a novel member of the endothelin family, stimulated a rapid increase in the intracellular Ca2+ concentration in fura-2-loaded Swiss 3T3 cells.	Fura-2	160-166	endothelin 1	Mus musculus	70-80
32858189-9	2020	Intriguingly, ROS scavenger, Vitamin C, could rescue ET-1-induced chondrocyte senescence in vitro associated with restoration of mitochondrial dynamics.	ros	14-17	endothelin 1	Mus musculus	53-57
32858189-9	2020	Intriguingly, ROS scavenger, Vitamin C, could rescue ET-1-induced chondrocyte senescence in vitro associated with restoration of mitochondrial dynamics.	Ascorbic Acid	29-38	endothelin 1	Mus musculus	53-57
34958971-11	2022	The mice implanted with the bio-mimicking M2-PCL nanofibers effectively inhibited toll like receptors signaling induced NF-kB and IRF-5 and their target genes such as Edn-1, IL-6, iNOS, TNF-alpha, etc.	polycaprolactone	45-48	endothelin 1	Mus musculus	167-172
33032098-10	2020	In mouse mesenteric arteries, sulforaphane reduced contraction evoked by potassium (p < 0.001), phenylephrine and endothelin 1 (all p < 0.001).	sulforaphane	30-42	endothelin 1	Mus musculus	114-126
34977503-6	2022	Mice pretreated with a GlyT1-A, which increases synaptic glycine levels, exhibited smaller stroke volume, reduced cell death, and minimized behavioral deficits following stroke induction by either photothrombosis or endothelin-1.	Glycine	57-64	endothelin 1	Mus musculus	216-228
34868457-18	2021	Furthermore, Tempol or Go 6983 pretreatment decreased ET-1, iNOS, and p-PKC expression and increased eNOS expression in HUVECs.	tempol	13-19	endothelin 1	Mus musculus	54-58
34868457-18	2021	Furthermore, Tempol or Go 6983 pretreatment decreased ET-1, iNOS, and p-PKC expression and increased eNOS expression in HUVECs.	2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide	23-30	endothelin 1	Mus musculus	54-58
34868457-19	2021	Conclusion: ROS mediate the vasoconstrictor response within the cold-induced vascular response, and ROS in blood vessel tissues rather than nerve fibers are involved in vasoconstriction via the ROS/RhoA/ROCK1 and ROS/PKC/ET-1 pathways in VSMCs and endothelial cells.	Reactive Oxygen Species	12-15	endothelin 1	Mus musculus	221-225
34868457-19	2021	Conclusion: ROS mediate the vasoconstrictor response within the cold-induced vascular response, and ROS in blood vessel tissues rather than nerve fibers are involved in vasoconstriction via the ROS/RhoA/ROCK1 and ROS/PKC/ET-1 pathways in VSMCs and endothelial cells.	Reactive Oxygen Species	100-103	endothelin 1	Mus musculus	221-225
34355294-5	2021	We found in controls that adenine feeding and UUO caused marked upregulations of endothelin-1 (ET-1) gene expression in endothelial and in tubular cells and a strong upregulation of ETA-receptor (ETA-R) gene expression in interstitial and mesangial cells, while the gene expression of ETB-receptor (ETB-R) did not change.	Adenine	26-33	endothelin 1	Mus musculus	81-93
34840823-8	2021	Bosentan inhibited ET-1 expression in plasma (P < 0.05) and RPE/choroid/sclera complexes at P28 in rd10 mice.	Bosentan	0-8	endothelin 1	Mus musculus	19-23
34355294-5	2021	We found in controls that adenine feeding and UUO caused marked upregulations of endothelin-1 (ET-1) gene expression in endothelial and in tubular cells and a strong upregulation of ETA-receptor (ETA-R) gene expression in interstitial and mesangial cells, while the gene expression of ETB-receptor (ETB-R) did not change.	Adenine	26-33	endothelin 1	Mus musculus	95-99
34355294-9	2021	In summary, our findings suggest that adenine feeding and UUO activate endothelin signaling in interstitial cells which is due to upregulated ETA-R expression and enhanced renal ET-1 production Our data also suggest that the activation of endothelin signaling in interstitial cells has less impact for the development of experimentally induced fibrosis.	Adenine	38-45	endothelin 1	Mus musculus	178-182
34343209-6	2021	ET-1 induced a slow contraction of non-activated HSCs, which was inhibited by the non-muscle myosin II inhibitor blebbistatin, the calmodulin inhibitor W-7, and the ETA receptor antagonist ambrisentan.	blebbistatin	113-125	endothelin 1	Mus musculus	0-4
34343209-6	2021	ET-1 induced a slow contraction of non-activated HSCs, which was inhibited by the non-muscle myosin II inhibitor blebbistatin, the calmodulin inhibitor W-7, and the ETA receptor antagonist ambrisentan.	W 7	152-155	endothelin 1	Mus musculus	0-4
34343209-6	2021	ET-1 induced a slow contraction of non-activated HSCs, which was inhibited by the non-muscle myosin II inhibitor blebbistatin, the calmodulin inhibitor W-7, and the ETA receptor antagonist ambrisentan.	ambrisentan	189-200	endothelin 1	Mus musculus	0-4
34343209-10	2021	ET-1-induced contraction was not affected by amlodipine, a VDCC blocker, whereas it was partly reduced by Gd3+ and amiloride, non-selective cation channel blockers.	ganglioside, GD3	106-110	endothelin 1	Mus musculus	0-4
34343209-10	2021	ET-1-induced contraction was not affected by amlodipine, a VDCC blocker, whereas it was partly reduced by Gd3+ and amiloride, non-selective cation channel blockers.	Amiloride	115-124	endothelin 1	Mus musculus	0-4
35193162-6	2022	ABSTRACT: Increased extracellular magnesium concentration has been shown to attenuate the endothelin-1-induced contractile response via the release of nitric oxide (NO) from the endothelium in proximal pulmonary arteries (PAs) of chronic hypoxic mice.	Magnesium	34-43	endothelin 1	Mus musculus	90-102
35468098-8	2022	RESULTS: ET-1 was positively correlated with HbA1c, creatinine levels, and duration of disease, and negatively correlated with AMS/ht2.	Creatinine	52-62	endothelin 1	Mus musculus	9-13
35413222-8	2022	These findings suggest the ET-1/ETA signaling pathway contributes to in renal iron trafficking in a murine model of iron overload.	Iron	78-82	endothelin 1	Mus musculus	27-35
35413222-8	2022	These findings suggest the ET-1/ETA signaling pathway contributes to in renal iron trafficking in a murine model of iron overload.	Iron	116-120	endothelin 1	Mus musculus	27-35
34089101-3	2021	AAV-mediated dON expression markedly decreased endothelin-1 induced cardiomyocyte hypertrophy in vitro and resulted in efficient expression of these dONs in the heart of adult mice as evidenced by fluorescent in situ hybridization.	CHEMBL2031461	0-3	endothelin 1	Mus musculus	47-59
34089101-3	2021	AAV-mediated dON expression markedly decreased endothelin-1 induced cardiomyocyte hypertrophy in vitro and resulted in efficient expression of these dONs in the heart of adult mice as evidenced by fluorescent in situ hybridization.	Diazooxonorleucine	13-16	endothelin 1	Mus musculus	47-59
34719652-8	2021	Additionally, real-time PCR analysis indicated that administration of HC-067047 and RN-1734 reversed the FPI-induced increase in mRNA levels of endogenous causal factors for BBB disruption, including matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor-A (VEGF-A), and endothelin-1 (ET-1).	HC-067047	70-79	endothelin 1	Mus musculus	287-299
34719652-8	2021	Additionally, real-time PCR analysis indicated that administration of HC-067047 and RN-1734 reversed the FPI-induced increase in mRNA levels of endogenous causal factors for BBB disruption, including matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor-A (VEGF-A), and endothelin-1 (ET-1).	HC-067047	70-79	endothelin 1	Mus musculus	301-305
34719652-8	2021	Additionally, real-time PCR analysis indicated that administration of HC-067047 and RN-1734 reversed the FPI-induced increase in mRNA levels of endogenous causal factors for BBB disruption, including matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor-A (VEGF-A), and endothelin-1 (ET-1).	RN 1734	84-91	endothelin 1	Mus musculus	287-299
34719652-8	2021	Additionally, real-time PCR analysis indicated that administration of HC-067047 and RN-1734 reversed the FPI-induced increase in mRNA levels of endogenous causal factors for BBB disruption, including matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor-A (VEGF-A), and endothelin-1 (ET-1).	RN 1734	84-91	endothelin 1	Mus musculus	301-305
34719652-10	2021	Treatment with HC-067047 and RN-1734 inhibited the increase in mRNA levels of MMP-9, VEGF-A, and ET-1 in cultured astrocytes subjected to in vitro FPI.	HC-067047	15-24	endothelin 1	Mus musculus	97-101
34719652-10	2021	Treatment with HC-067047 and RN-1734 inhibited the increase in mRNA levels of MMP-9, VEGF-A, and ET-1 in cultured astrocytes subjected to in vitro FPI.	RN 1734	29-36	endothelin 1	Mus musculus	97-101
35466825-0	2022	Endothelin-1 down-regulated vascular endothelial growth factor A is involved in trichloroethene-induced kidney injury.	Trichloroethylene	80-95	endothelin 1	Mus musculus	0-12
35466825-2	2022	This study aimed to investigate the role of endothelin-1 (ET-1)/vascular endothelial-derived growth factor-A (VEGF-A) in trichloroethylene (TCE)-induced renal injury.	Trichloroethylene	140-143	endothelin 1	Mus musculus	44-56
35466825-2	2022	This study aimed to investigate the role of endothelin-1 (ET-1)/vascular endothelial-derived growth factor-A (VEGF-A) in trichloroethylene (TCE)-induced renal injury.	Trichloroethylene	140-143	endothelin 1	Mus musculus	58-62
35466825-8	2022	The results showed that TCE-sensitized mouse kidneys were damaged and accompanied by increased serum ET-1.	Trichloroethylene	24-27	endothelin 1	Mus musculus	101-105
35466825-9	2022	After treatment with CGS 35066, the inhibitor of endothelin converting enzyme-1 (ECE-1), kidney ET-1, TNF-alpha and VCAM-1 levels decreased, and renal function improved in TCE+CGS 35066-sensitized positive mice.	CGS 35066	21-30	endothelin 1	Mus musculus	96-100
35129370-6	2022	The increased sodium retention is associated with altered expression of glucocorticoid and mineralocorticoid receptors, increased serum aldosterone, and increased medullary endothelin-1 compared to control (CNTL) mice.	Sodium	14-20	endothelin 1	Mus musculus	173-185
35193162-6	2022	ABSTRACT: Increased extracellular magnesium concentration has been shown to attenuate the endothelin-1-induced contractile response via the release of nitric oxide (NO) from the endothelium in proximal pulmonary arteries (PAs) of chronic hypoxic mice.	Nitric Oxide	151-163	endothelin 1	Mus musculus	90-102
2473319-2	1989	The ET-1 induced constrictions in mice were prevented by indomethacin.	Indomethacin	57-69	endothelin 1	Mus musculus	4-8
2551284-0	1989	Cyclosporine increases endothelin-1 binding site density in cardiac cell membranes.	Cyclosporine	0-12	endothelin 1	Mus musculus	23-35
2551284-2	1989	Cyclosporine-treated mice were used to investigate whether a cyclosporine dose regime which produces cardiac fibrosis and calcification alters the density of the specific binding sites for the endothelial-derived vasoconstrictor polypeptide, endothelin-1.	Cyclosporine	61-73	endothelin 1	Mus musculus	242-254
2551284-4	1989	This increase in endothelin-1 binding site density could contribute to the cytotoxic effects of cyclosporine.	Cyclosporine	96-108	endothelin 1	Mus musculus	17-29
2558572-2	1989	ET specifically binds to a single class of high-affinity receptors in MC3T3-E1 cells and induces phospholipase C activation with the production of two second messengers, inositol trisphosphate and 1,2-diacylglycerol, and a biphasic increase in intracellular free Ca2+ concentration ([Ca2+]i), which consists of an initial transient increase and an ensuing sustained plateau, as measured with a fluorescent indicator, fura-2.	inositol 1,2,3-trisphosphate	170-192	endothelin 1	Mus musculus	0-2
2558572-2	1989	ET specifically binds to a single class of high-affinity receptors in MC3T3-E1 cells and induces phospholipase C activation with the production of two second messengers, inositol trisphosphate and 1,2-diacylglycerol, and a biphasic increase in intracellular free Ca2+ concentration ([Ca2+]i), which consists of an initial transient increase and an ensuing sustained plateau, as measured with a fluorescent indicator, fura-2.	1,2-diacylglycerol	197-215	endothelin 1	Mus musculus	0-2
2558572-2	1989	ET specifically binds to a single class of high-affinity receptors in MC3T3-E1 cells and induces phospholipase C activation with the production of two second messengers, inositol trisphosphate and 1,2-diacylglycerol, and a biphasic increase in intracellular free Ca2+ concentration ([Ca2+]i), which consists of an initial transient increase and an ensuing sustained plateau, as measured with a fluorescent indicator, fura-2.	Fura-2	417-423	endothelin 1	Mus musculus	0-2
2558572-4	1989	The ET-stimulated production of inositol trisphosphate is not abolished by removal of extracellular Ca2+, indicating that ET-stimulated phospholipase C activation is not a consequence of an increase in Ca2+ influx across the plasma membrane.	inositol 1,2,3-trisphosphate	32-54	endothelin 1	Mus musculus	4-6
2558572-4	1989	The ET-stimulated production of inositol trisphosphate is not abolished by removal of extracellular Ca2+, indicating that ET-stimulated phospholipase C activation is not a consequence of an increase in Ca2+ influx across the plasma membrane.	inositol 1,2,3-trisphosphate	32-54	endothelin 1	Mus musculus	122-124
2558572-6	1989	A protein kinase C activator phorbol 12,13-dibutyrate mimics these effects of ET.	Phorbol 12,13-Dibutyrate	29-53	endothelin 1	Mus musculus	78-80
2558572-7	1989	The results demonstrate that ET activates the inositol lipid signaling pathway and induces mobilization of Ca2+ from both extra- and intracellular pools and activation of protein kinase C in osteoblastic MC3T3-E1 cells.	Inositol	46-54	endothelin 1	Mus musculus	29-31
33711514-10	2021	Mice treated with terazosin had a significant decrease in serum creatinine, urinary Kim-1 levels, HIF-1alpha, apoptosis, and downstream Adrab1 genes including Ece1, Edn1, pMAPK14 with increased cell proliferation.	Terazosin	18-27	endothelin 1	Mus musculus	165-169
33838160-5	2021	The effect of endothelin-1 on astrocyte sonic hedgehog expression was suppressed by an ETB antagonist BQ788, but was unchanged by the ETA antagonist FR139317.	BQ 788	102-107	endothelin 1	Mus musculus	14-26
33624556-5	2021	Untreated HbSS mice exhibited increased proteinuria, elevated plasma endothelin-1 (ET-1), and reduced urine concentrating ability compared to HbAA mice.	hbss	10-14	endothelin 1	Mus musculus	69-81
33624556-5	2021	Untreated HbSS mice exhibited increased proteinuria, elevated plasma endothelin-1 (ET-1), and reduced urine concentrating ability compared to HbAA mice.	hbss	10-14	endothelin 1	Mus musculus	83-87
33624556-6	2021	Hydroxyurea reduced proteinuria and plasma ET-1 levels in HbSS mice.	Hydroxyurea	0-11	endothelin 1	Mus musculus	43-47
33624556-6	2021	Hydroxyurea reduced proteinuria and plasma ET-1 levels in HbSS mice.	hbss	58-62	endothelin 1	Mus musculus	43-47
33421591-5	2021	Notably, ET-1 administration increased spinal glutamate acid decarboxylases (GAD65/67) expression via initiating HDAC5 nuclear exportation and increased the acetylation of histone 3 at lysine 9 (Acetyl-H3K9) in the promotor regions of spinal Gad1 and Gad2 genes.	Glutamic Acid	46-55	endothelin 1	Mus musculus	9-13
33421591-5	2021	Notably, ET-1 administration increased spinal glutamate acid decarboxylases (GAD65/67) expression via initiating HDAC5 nuclear exportation and increased the acetylation of histone 3 at lysine 9 (Acetyl-H3K9) in the promotor regions of spinal Gad1 and Gad2 genes.	Lysine	185-191	endothelin 1	Mus musculus	9-13
33421591-5	2021	Notably, ET-1 administration increased spinal glutamate acid decarboxylases (GAD65/67) expression via initiating HDAC5 nuclear exportation and increased the acetylation of histone 3 at lysine 9 (Acetyl-H3K9) in the promotor regions of spinal Gad1 and Gad2 genes.	acetyl-h3k9	195-206	endothelin 1	Mus musculus	9-13
33727850-0	2021	Endothelin-1/Endothelin Receptor Type A-Angiopoietins/Tie-2 Pathway in Regulating the Cross Talk Between Glomerular Endothelial Cells and Podocytes in Trichloroethylene-Induced Renal Immune Injury.	Trichloroethylene	151-168	endothelin 1	Mus musculus	0-12
33727850-10	2021	In TCE sensitized positive mouse, the downregulation of Ang-1, pTie-2 and the upregulation of Ang-2 were mediated by ET-1/ETAR but not ET-1/ETBR.	Trichloroethylene	3-6	endothelin 1	Mus musculus	117-121
34039912-3	2021	ET-1 has been shown to stimulate the release of aldosterone.	Aldosterone	48-59	endothelin 1	Mus musculus	0-4
33786807-6	2021	Conversely, treatment of ferulic acid against the ETRA to counteract the ET1-mediated vasoconstriction for 30 days prevented reductions of density and diameter of hippocampal capillaries as well as ameliorated Abeta plaque deposition and spatial memory deficit at 7 months old in AD mice.	ferulic acid	25-37	endothelin 1	Mus musculus	73-76
33711514-12	2021	Inhibition of Adra1b with terazosin abrogated Ece1, Edn1, and contrast-induced Fsp-1, Mmp-2, Mmp-9 expression, and caspase-3/7 activity in HK-2 cells.	Terazosin	26-35	endothelin 1	Mus musculus	52-56
33469864-9	2021	This pro-fibrotic effect was also negated by RGD (Arg-Gly-Asp)-peptide magnetic nanoparticles target delivery of ET-1 small interfering RNA to ECs in mice.	arg-gly-asp)-peptide	50-70	endothelin 1	Mus musculus	113-117
33154104-4	2021	In anesthetized mice, mast cell degranulation induced by Compound 48/80 (C48/80) or stabilization by cromolyn enhanced or repressed, respectively, the dose-dependent vasopressor responses to big ET-1 in wild-type (WT) mice but not in mMCP-4 knockout mice in a chymase inhibitor (TY-51469)-sensitive fashion.	Cromolyn Sodium	101-109	endothelin 1	Mus musculus	195-199
33154104-6	2021	Furthermore, C48/80 or cromolyn markedly increased or abolished, respectively, ET-1 (1-31) conversion from exogenous big ET-1 in WT mice peritoneal fluid-isolated mast cells, in vitro.	Cromolyn Sodium	23-31	endothelin 1	Mus musculus	79-83
33154104-6	2021	Furthermore, C48/80 or cromolyn markedly increased or abolished, respectively, ET-1 (1-31) conversion from exogenous big ET-1 in WT mice peritoneal fluid-isolated mast cells, in vitro.	Cromolyn Sodium	23-31	endothelin 1	Mus musculus	121-125
33542786-5	2021	Furthermore, we found that HTHQ treatment significantly decreased soluble endoglin (sEng), endothelin-1 (ET-1), and activin A and restored vascular endothelial growth factor (VEGF) in preeclamptic mice.	1-O-hexyl-2,3,5-trimethylhydroquinone	27-31	endothelin 1	Mus musculus	91-103
33542786-5	2021	Furthermore, we found that HTHQ treatment significantly decreased soluble endoglin (sEng), endothelin-1 (ET-1), and activin A and restored vascular endothelial growth factor (VEGF) in preeclamptic mice.	1-O-hexyl-2,3,5-trimethylhydroquinone	27-31	endothelin 1	Mus musculus	105-109
32535962-1	2021	BACKGROUND: Endothelin-1 (EDN1) can evoke histamine-independent pruritus in mammals and is upregulated in the lesional epidermis of atopic dermatitis (AD).	Histamine	42-51	endothelin 1	Mus musculus	12-24
32535962-1	2021	BACKGROUND: Endothelin-1 (EDN1) can evoke histamine-independent pruritus in mammals and is upregulated in the lesional epidermis of atopic dermatitis (AD).	Histamine	42-51	endothelin 1	Mus musculus	26-30
32535962-9	2021	Histologically, the number of infiltrated dermal cells, the epidermal EDN1 expression, and the number of intraepidermal nerve fibers were significantly inhibited upon bosentan application.	Bosentan	167-175	endothelin 1	Mus musculus	70-74
33639057-9	2021	Propofol exerts effect in inhibiting ET-1 and fibronectin expression and the formation of ROS induced by Ag II.	Propofol	0-8	endothelin 1	Mus musculus	37-41
32891972-7	2021	In addition, enzyme-linked immunosorbent assay analysis showed La(NO3)3 could ameliorate the dysfunction of vascular endothelium with declined endothelin-1 and increased prostacyclin.	la(no3)3	63-71	endothelin 1	Mus musculus	143-155
33082140-8	2020	Similarly, rosiglitazone increased miR-98 and reversed nicotine-induced increases in NGF, FN1, and ET-1.	Rosiglitazone	11-24	endothelin 1	Mus musculus	99-103
33361535-8	2021	GABA-salt also reduced diet-induced reductions in the levels of eNOS, phosphorylated eNOS, VSMC proliferation and medial thickening in mouse aortic tissues, and attenuated Endothelin-1 levels in salt treated VSMCs.	gamma-Aminobutyric Acid	0-4	endothelin 1	Mus musculus	172-184
33361535-8	2021	GABA-salt also reduced diet-induced reductions in the levels of eNOS, phosphorylated eNOS, VSMC proliferation and medial thickening in mouse aortic tissues, and attenuated Endothelin-1 levels in salt treated VSMCs.	Salts	5-9	endothelin 1	Mus musculus	172-184
33361535-8	2021	GABA-salt also reduced diet-induced reductions in the levels of eNOS, phosphorylated eNOS, VSMC proliferation and medial thickening in mouse aortic tissues, and attenuated Endothelin-1 levels in salt treated VSMCs.	Salts	195-199	endothelin 1	Mus musculus	172-184
33355986-9	2021	Notably, B16 melanoma cells treated with 10 nmol/L ET-1 exhibited significantly higher melanin synthesis, tyrosinase activity, TYR and TRP-1 mRNA expression levels compared with untreated cells.	Melanins	87-94	endothelin 1	Mus musculus	51-55
33355986-9	2021	Notably, B16 melanoma cells treated with 10 nmol/L ET-1 exhibited significantly higher melanin synthesis, tyrosinase activity, TYR and TRP-1 mRNA expression levels compared with untreated cells.	Tyrosine	127-130	endothelin 1	Mus musculus	51-55
33082140-8	2020	Similarly, rosiglitazone increased miR-98 and reversed nicotine-induced increases in NGF, FN1, and ET-1.	Nicotine	55-63	endothelin 1	Mus musculus	99-103
32763311-0	2020	Local renal complement activation mediates immune kidney injury by inducing endothelin-1 signalling and inflammation in trichloroethylene-sensitised mice.	Trichloroethylene	120-137	endothelin 1	Mus musculus	76-88
33339328-7	2020	The expressions of the adhesion molecules, intercellular adhesion molecule and vascular cell adhesion molecule, and endothelin-1 were increased by HFD and were decreased by ECE and PPB.	PPB	181-184	endothelin 1	Mus musculus	116-128
32946866-4	2020	In the formalin test, ET1 reduced both neurogenic and inflammatory phase of nociception induced by the aldehyde.	Formaldehyde	7-15	endothelin 1	Mus musculus	22-25
32946866-4	2020	In the formalin test, ET1 reduced both neurogenic and inflammatory phase of nociception induced by the aldehyde.	Aldehydes	103-111	endothelin 1	Mus musculus	22-25
32946866-5	2020	Similarly, ET1 strongly reduced paw licking response in the capsaicin test, the abdominal stretching in the writhing test and the carrageenan-induced thermal hyperalgesia.	Capsaicin	60-69	endothelin 1	Mus musculus	11-14
32946866-5	2020	Similarly, ET1 strongly reduced paw licking response in the capsaicin test, the abdominal stretching in the writhing test and the carrageenan-induced thermal hyperalgesia.	Carrageenan	130-141	endothelin 1	Mus musculus	11-14
33069239-5	2020	In contrast, administration of specific endothelin-1 inhibitors (BQ610 and BQ788) significantly inhibited progression of these diseases accompanied with reduced T cell responses to the respective antigens.	BQ 610	65-70	endothelin 1	Mus musculus	40-52
33069239-5	2020	In contrast, administration of specific endothelin-1 inhibitors (BQ610 and BQ788) significantly inhibited progression of these diseases accompanied with reduced T cell responses to the respective antigens.	BQ 788	75-80	endothelin 1	Mus musculus	40-52
32763311-10	2020	Our research uncovered a novel role of local renal complement activation during immune kidney injury after TCE sensitisation through induction of ET-1 signalling and inflammation.	Trichloroethylene	107-110	endothelin 1	Mus musculus	146-150
32437627-2	2020	Additionally, we have shown that the endothelin-1 (ET-1) gene is targeted by both PER1 and aldosterone.	Aldosterone	91-102	endothelin 1	Mus musculus	37-49
32561219-8	2020	FPI-induced expression levels of ET-1 and ETB receptors were reduced by bosentan, but not by ambrisentan.	Bosentan	72-80	endothelin 1	Mus musculus	33-37
32561219-9	2020	In cultured mouse astrocytes and brain microvessel endothelial cells, ET-1 (100 nM) increased prepro--ET-1 mRNA, which was inhibited by bosentan, but not by ambrisentan.	Bosentan	136-144	endothelin 1	Mus musculus	70-74
32561219-9	2020	In cultured mouse astrocytes and brain microvessel endothelial cells, ET-1 (100 nM) increased prepro--ET-1 mRNA, which was inhibited by bosentan, but not by ambrisentan.	Bosentan	136-144	endothelin 1	Mus musculus	102-106
32437627-2	2020	Additionally, we have shown that the endothelin-1 (ET-1) gene is targeted by both PER1 and aldosterone.	Aldosterone	91-102	endothelin 1	Mus musculus	51-55
32437627-3	2020	We hypothesized that ET-1 would exhibit a sex-specific response to HS/DOCP treatment in PER1 KO.	Hydrogen	67-69	endothelin 1	Mus musculus	21-25
32437627-3	2020	We hypothesized that ET-1 would exhibit a sex-specific response to HS/DOCP treatment in PER1 KO.	DESOXYCORTICOSTERONE PIVALATE	70-74	endothelin 1	Mus musculus	21-25
32437627-7	2020	Finally, siRNA-mediated knockdown of PER1 in mouse cortical collecting duct cells (mpkCCDc14) resulted in increased ET-1 mRNA expression and peptide secretion in response to aldosterone treatment.	Aldosterone	174-185	endothelin 1	Mus musculus	116-120
32437627-8	2020	These data suggest that PER1 is a negative regulator of ET-1 expression in response to HS/DOCP, revealing a novel mechanism for the regulation of renal Na handling in response to HS/DOCP treatment.	DESOXYCORTICOSTERONE PIVALATE	90-94	endothelin 1	Mus musculus	56-60
32437627-8	2020	These data suggest that PER1 is a negative regulator of ET-1 expression in response to HS/DOCP, revealing a novel mechanism for the regulation of renal Na handling in response to HS/DOCP treatment.	DESOXYCORTICOSTERONE PIVALATE	182-186	endothelin 1	Mus musculus	56-60
31957020-9	2020	Treatment with endothelin-1 (100 nM) decreased angiopoietin-1 production in cultured astrocytes and the effect was inhibited by BQ788 (1 muM).	BQ 788	128-133	endothelin 1	Mus musculus	15-27
32849906-5	2020	The results also showed that treatment with LP-YS4 significantly reduced the serum concentrations of ET-1, SP, and IL-10 while significantly increasing those of SS, VIP, and IL-2 in colitis mice (P < 0.05).	lp-ys4	44-50	endothelin 1	Mus musculus	101-105
32407295-9	2020	Lowering Abeta42 reversed the DIO deficit in the eNOS/cGMP/PKG pathway and decreased endothelin-1.	UNII-042A8N37WH	9-16	endothelin 1	Mus musculus	85-97
32393148-11	2020	Direct stimulation of GC-1 (BAY-602770) offset disparate mTORC1 activation between PKG1alphaWT and PKG1alphaCS/CS after PO, and blocked ET-1 stimulated mTORC1 in TSC2S1365A expressing myocytes.	bay-602770	28-38	endothelin 1	Mus musculus	136-140
32487560-6	2020	Water-loaded endothelin A receptor knockout mice, compared with control mice, had markedly enhanced urine volume and reduced urine osmolality associated with increased urinary endothelin-1 and PGE2 excretion, increased cyclooxygenase-2 protein expression, and decreased inner medullary aquaporin-2 protein content.	Water	0-5	endothelin 1	Mus musculus	176-188
31970838-6	2020	Troglitazone blunted ET-1-induced contraction of UtA in hypoxic and normoxic dams equivalently.	troglitazone	0-12	endothelin 1	Mus musculus	21-25
32052660-9	2020	On the other hand, carvedilol significantly reduced the heart weight, FBG, serum insulin, IR index, serum endothelin-1, cardiac DAG, left ventricular thickness, right ventricular fibrosis, and degeneration of cardiac myofibrils.	Carvedilol	19-29	endothelin 1	Mus musculus	106-118
32572011-7	2020	The use of antioxidants and several antagonists revealed that ET-1 effect on senescence and fibrosis depended on ROS production and activation of PI3K-AKT-GSK pathway.	ros	113-116	endothelin 1	Mus musculus	62-66
31970838-7	2020	Immunohistological analysis revealed enhanced staining for ET-1 receptors in the placental labyrinthine zone in hypoxic compared to normoxic dams.	zinc oxide-non-eugenol cement	91-108	endothelin 1	Mus musculus	59-63
31770577-8	2020	Results showed that PA significantly increased ROS generation and the levels of pro-apoptotic protein Bax, and decreased the levels of anti-apoptotic protein Bcl-2 and the mRNA expression and secretion of endothelin-1.	Palmitic Acid	20-22	endothelin 1	Mus musculus	205-217
31923844-5	2020	As compared to the wild type (WT) mice, cerulein treatment in KC mice resulted in significantly higher levels of ECE-1, ET-1, ETAR and ETBR, transcripts in the pancreas.	Ceruletide	40-48	endothelin 1	Mus musculus	120-124
31770577-12	2020	In conclusion, liraglutide ameliorates the PA-induced oxidative stress, apoptosis, and endothelin-1 secretion dysfunction in mouse IMECs through GLP-1R/PKA and GTPCH1/eNOS signaling pathways.	Palmitic Acid	43-45	endothelin 1	Mus musculus	87-99
31752395-0	2019	The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver.	Bile Acids and Salts	22-31	endothelin 1	Mus musculus	65-77
31948482-7	2020	RESULTS: The response of thoracic aorta to phenylephrine and endothelin-1 was increased in Ang II-infused Cyp1b1+/+ mice compared to intact Cyp1b1-/- or castrated Cyp1b1+/+ and Cyp1b1-/- mice; these effects of Ang II were restored by treatment with 6beta-OHT.	4,17 beta-dihydroxy-4-androstene-3-one	249-258	endothelin 1	Mus musculus	61-73
31735744-5	2019	Nicotine reportedly increases the occurrence of abdominal aortic aneurysms by activating endothelin-1 (ET-1), angiotensinogen and the angiotensin II type 1 (AT1) receptor, leading to an increase in neutrophil elastase, oxidative stress, and matrix metalloproteinase (MMP)-2 expression, which causes vascular wall weakness and damage.	Nicotine	0-8	endothelin 1	Mus musculus	89-101
31735744-5	2019	Nicotine reportedly increases the occurrence of abdominal aortic aneurysms by activating endothelin-1 (ET-1), angiotensinogen and the angiotensin II type 1 (AT1) receptor, leading to an increase in neutrophil elastase, oxidative stress, and matrix metalloproteinase (MMP)-2 expression, which causes vascular wall weakness and damage.	Nicotine	0-8	endothelin 1	Mus musculus	103-107
31735744-6	2019	Immunohistological analyses have indicated that isoflavone significantly inhibits the activation of ET-1, angiotensinogen and the AT1 receptor in nicotine-administered mice.	Isoflavones	48-58	endothelin 1	Mus musculus	100-104
31735744-6	2019	Immunohistological analyses have indicated that isoflavone significantly inhibits the activation of ET-1, angiotensinogen and the AT1 receptor in nicotine-administered mice.	Nicotine	146-154	endothelin 1	Mus musculus	100-104
31695563-10	2019	Results: 20 (S)-ginsenoside Rg3 significantly decreased the UI scores and UI ratios in all the three GU models, and it demonstrated antiulcer effects by decreasing the ET-1 and NOS2 levels and increasing the NO, superoxide dismutase, EGF, and epidermal growth factor receptor levels.	ginsenoside Rg3	12-31	endothelin 1	Mus musculus	168-172
31442451-5	2019	FK506-mediated inhibition of the calcineurin-NFAT pathway in the HL-1 cells selectively inhibited the stimulatory effect of the conditioned medium derived from ET-1-pre-stimulated endothelial cells on cardiomyocyte fetal gene expression.	Tacrolimus	0-5	endothelin 1	Mus musculus	160-164
30926169-0	2019	Aldosterone induced up-expression of ICAM-1 and ET-1 in pancreatic islet endothelium may associate with progression of T2D.	Aldosterone	0-11	endothelin 1	Mus musculus	48-52
31310581-5	2019	In aggregate, we conclude that ET-1 signaling is not implicated in the development of visceral AT inflammation but promotes glucose intolerance, thus representing an important therapeutic target for glycemic dysregulation in conditions characterized by hyperendothelinemia.	Glucose	124-131	endothelin 1	Mus musculus	31-35
31111864-2	2019	Although endothelin-1 (ET-1) plays an important role in vascular inflammation and reactive oxygen species production, the individual effect of ET-1 in atherogenesis remains unclear.	Oxygen	91-97	endothelin 1	Mus musculus	9-21
31111864-2	2019	Although endothelin-1 (ET-1) plays an important role in vascular inflammation and reactive oxygen species production, the individual effect of ET-1 in atherogenesis remains unclear.	Oxygen	91-97	endothelin 1	Mus musculus	23-27
31281522-8	2019	During early stages of tumor progression concurrent use of CORM-A1 and DETA/NO demonstrated vasoprotective ability (decreased endothelin-1, sICAM and sE-selectin plasma level) and downregulated platelets activation (decreased bound of fibrinogen and vWf to platelets) as well as inhibited EMT process.	DEET	71-75	endothelin 1	Mus musculus	126-138
31422694-6	2019	Additionally, we report that smooth muscle-specific Bbs1 knockout mice demonstrate enhanced ET-1 (endothelin-1)-induced contractility of mesenteric arteries-an effect reversed by blockade of the AT1 (angiotensin type 1 receptor) with losartan.	Losartan	234-242	endothelin 1	Mus musculus	98-110
31248984-5	2019	ET-1 has been reported to mediate superoxide formation in the vascular system via NADPH oxidase (NOX) and to regulate the actin cytoskeleton of cancer cell lines via the cofilin pathway.	Superoxides	34-44	endothelin 1	Mus musculus	0-4
31025223-8	2019	Moreover, CBS and CLS inhibitors did not alter the endothelin-1 levels possibly suggesting that endothelin-1 may act as upstream mediator of H2S.	Hydrogen Sulfide	141-144	endothelin 1	Mus musculus	96-108
31025223-9	2019	It is concluded that RIPC may stimulate the release endothelin-1, which may activate CBS and CLS to increase the levels of H2S and latter may increase the expression of Nrf2 to decrease oxidative stress and prevent vascular dementia.	Hydrogen Sulfide	123-126	endothelin 1	Mus musculus	52-64
31234522-1	2019	(1) Background: Angiotensin II (Ang II) and endothelin 1 (ET-1) generate reactive oxygen species (ROS) that can activate cyclooxygenase (COX).	Reactive Oxygen Species	73-96	endothelin 1	Mus musculus	44-56
31234522-1	2019	(1) Background: Angiotensin II (Ang II) and endothelin 1 (ET-1) generate reactive oxygen species (ROS) that can activate cyclooxygenase (COX).	Reactive Oxygen Species	73-96	endothelin 1	Mus musculus	58-62
31234522-1	2019	(1) Background: Angiotensin II (Ang II) and endothelin 1 (ET-1) generate reactive oxygen species (ROS) that can activate cyclooxygenase (COX).	Reactive Oxygen Species	98-101	endothelin 1	Mus musculus	44-56
31234522-1	2019	(1) Background: Angiotensin II (Ang II) and endothelin 1 (ET-1) generate reactive oxygen species (ROS) that can activate cyclooxygenase (COX).	Reactive Oxygen Species	98-101	endothelin 1	Mus musculus	58-62
31234522-3	2019	We hypothesized that COX and TPRs are upstream requirements for the generation of vascular ROS by ET-1.	Reactive Oxygen Species	91-94	endothelin 1	Mus musculus	98-102
31234522-8	2019	(4) Conclusion: Activation of vascular TPRs by COX products are required for ET-1 to increase vascular contractions and ROS generation from NADPH oxidase and reduce ROS metabolism by SOD.	Reactive Oxygen Species	120-123	endothelin 1	Mus musculus	77-81
31234522-8	2019	(4) Conclusion: Activation of vascular TPRs by COX products are required for ET-1 to increase vascular contractions and ROS generation from NADPH oxidase and reduce ROS metabolism by SOD.	Reactive Oxygen Species	165-168	endothelin 1	Mus musculus	77-81
31022427-3	2019	In this study, our results showed that pregnancy CBNPs exposure induced the persistent pathological changes in the cerebral cortex tissues and impaired cerebrovascular function of mice manifested by significant alterations of endothelin-1, endothelial nitric oxide synthase, vascular endothelial growth factor-A and ATP-binding cassette transporter G1.	cbnps	49-54	endothelin 1	Mus musculus	226-238
30926169-10	2019	We next determined that aldosterone increased expression of ICAM-1 and ET-1 in both mRNA and protein levels in islet endothelium in vitro.	Aldosterone	24-35	endothelin 1	Mus musculus	71-75
30926169-12	2019	Our results showed that aldosterone can up-regulate the expression levels of ICAM-1 and ET-1 through MR.	Aldosterone	24-35	endothelin 1	Mus musculus	88-92
30926764-2	2019	In this study, STZ-diabetic ETBR-/- mice was characterized by increased serum creatinine and urinary albumin, enhanced glomerulosclerosis, and upregulated ET-1 expression compared with STZ-diabetic WT mice.	Streptozocin	15-18	endothelin 1	Mus musculus	155-159
30926764-4	2019	In addition, ET-1 was over-expressed in ETBR-/- GENs and was regulated by NF-kapapB pathway.	Genistein	48-52	endothelin 1	Mus musculus	13-17
30926764-5	2019	ET-1/ETBR suppressed NF-kappaB to modulate ET-1 in GENs.	Genistein	51-55	endothelin 1	Mus musculus	0-4
30926764-5	2019	ET-1/ETBR suppressed NF-kappaB to modulate ET-1 in GENs.	Genistein	51-55	endothelin 1	Mus musculus	43-47
30926764-8	2019	These results suggest that in HG-exposed ETBR-/- GENs, suppression of ET-1 binding to ETBR activated NF-kappaB pathway, thus to secrete large amount of ET-1.	Genistein	49-53	endothelin 1	Mus musculus	70-74
30926764-8	2019	These results suggest that in HG-exposed ETBR-/- GENs, suppression of ET-1 binding to ETBR activated NF-kappaB pathway, thus to secrete large amount of ET-1.	Genistein	49-53	endothelin 1	Mus musculus	152-156
30926764-9	2019	Due to the communication between GENs and mesangial cells in diabetes, ET-1 binding to ETAR in mesangial cell promoted RhoA/ROCK pathway, thus to accelerate mesangial cell proliferation and ECM accumulation.	Genistein	33-37	endothelin 1	Mus musculus	71-75
32309625-8	2019	Interestingly, ET-1 levels were negatively associated with some biomarkers (platelet factor 4, beta = -0.148, P = 0.0003; triglycerides, beta = -0.095, P = 0.041) and positively with other biomarkers: albumin (beta = 0.035, P = 0.006) and IL-lbeta (beta = 0.082, P = 0.012).	Triglycerides	122-135	endothelin 1	Mus musculus	15-19
30949450-9	2019	Furthermore, CQ significantly affected the transcription and secretion of platelet-derived growth factor (PDGF)-AB/BB (upregulated) and Endothelin-1 (EDN1, downregulated), both modulators of perivascular cell (PC) behavior.	Chloroquine	13-15	endothelin 1	Mus musculus	136-148
30949450-9	2019	Furthermore, CQ significantly affected the transcription and secretion of platelet-derived growth factor (PDGF)-AB/BB (upregulated) and Endothelin-1 (EDN1, downregulated), both modulators of perivascular cell (PC) behavior.	Chloroquine	13-15	endothelin 1	Mus musculus	150-154
30911541-10	2019	Conclusions: Treatment with Macitentan is associated with significant lower vertebral bone mass and therefore the secondary effect of dual antagonists to endothelin-1 receptors on the skeleton should be monitored and investigated in clinical practice.	macitentan	28-38	endothelin 1	Mus musculus	154-166
30623723-1	2019	The inner medullary collecting duct (IMCD) produces very high levels of endothelin-1 (ET-1) that acts as an autocrine inhibitor of IMCD Na+ and water reabsorption.	Water	144-149	endothelin 1	Mus musculus	72-84
30623723-1	2019	The inner medullary collecting duct (IMCD) produces very high levels of endothelin-1 (ET-1) that acts as an autocrine inhibitor of IMCD Na+ and water reabsorption.	Water	144-149	endothelin 1	Mus musculus	86-90
31685770-3	2019	GE (100 microg/mL) completely inhibited tumor necrosis factor-alpha-induced endothelin-1, monocyte chemoattractant protein-1, interleukin-1beta, and intercellular adhesion molecule-1 gene expression in cultured endothelial cells.	Germanium	0-2	endothelin 1	Mus musculus	76-88
31884664-4	2019	In this study, we analyzed mRNA expression levels of the endothelin signaling family in wild-type mice after a puncture of the eye, intravitreal PBS injections, or light-induced photoreceptor degeneration.	Lead	145-148	endothelin 1	Mus musculus	57-67
30622665-12	2018	Filtered water treatment restored the activity of antioxidant enzymes, downregulated ET-1, and Ang II in the serum of mice.	Water	9-14	endothelin 1	Mus musculus	85-89
31270306-10	2019	These results revealed that TCDD directly induces cardiotoxicity in the postnatal period represented by progressive hypertrophy in which ANP, beta-MHC, and ET-1 have potentials to mediate the cardiac hypertrophy and heart failure.	Polychlorinated Dibenzodioxins	28-32	endothelin 1	Mus musculus	156-160
30185506-5	2018	Rapamycin, an mTORC1 inhibitor, and bosentan, an EDN1 antagonist, eliminated the difference in renal function between TSC1fl/fl and Fibro-TSC1-/- mice after LPS injection.	Bosentan	36-44	endothelin 1	Mus musculus	49-53
30185506-6	2018	Rapamycin restored LPS-induced up-regulation of EDN1, endothelin converting enzyme-1 (ECE1), and p-JNK in TSC1-knockdown mouse embryonic fibroblasts (MEFs).	Sirolimus	0-9	endothelin 1	Mus musculus	48-52
30185506-7	2018	SP600125, a Jun-amino-terminal kinase (JNK) inhibitor, attenuated LPS-induced enhancement of EDN1 and ECE1 in TSC1-knockdown MEFs without a change in phospho-S6 ribosomal protein (p-S6) level.	pyrazolanthrone	0-8	endothelin 1	Mus musculus	93-97
30198212-5	2018	Vehicle and ABT-627-treated mice displayed significant upregulation of endothelin-1 (ET-1) in the IR compared to contralateral kidney at both 24 h and 10 days post-IR (P &lt; 0.001).	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	12-15	endothelin 1	Mus musculus	71-83
30227623-5	2018	Besides, catalpol co-administrated with LPS increased BMECs survival, decreased their endothelin-1, TNF-Alpha and IL-6 secretion, improved transmembrane electrical resistance in a time-dependent manner, and in addition increased the fluorescein sodium permeability coefficient of BMECs.	lps	40-43	endothelin 1	Mus musculus	86-98
30198212-5	2018	Vehicle and ABT-627-treated mice displayed significant upregulation of endothelin-1 (ET-1) in the IR compared to contralateral kidney at both 24 h and 10 days post-IR (P &lt; 0.001).	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	12-15	endothelin 1	Mus musculus	85-89
29658585-4	2018	The HSP90 inhibitors geldanamycin and 17-demethoxygeldanamycin (17-DMAG) significantly amplified HSP27 induction stimulated by ET-1 in a dose-dependent manner.	geldanamycin	21-33	endothelin 1	Mus musculus	127-131
30020318-0	2018	Curcumin exerts anti-inflammatory and vasoprotective effects through amelioration of NFAT-dependent endothelin-1 production in mice with acute Chagas cardiomyopathy.	Curcumin	0-8	endothelin 1	Mus musculus	100-112
29947534-0	2018	Vitamin D upregulates endothelin-1, ETBR, eNOS mRNA expression and attenuates vascular remodelling and ischemia in kidney fibrosis model in mice.	Vitamin D	0-9	endothelin 1	Mus musculus	22-34
29947534-1	2018	We examined the upregulation of ET-1/ETBR/eNOS signaling in renoprotective effect of vitamin D in kidney fibrosis model in mice using unilateral ureteral obstruction (UUO).	Vitamin D	85-94	endothelin 1	Mus musculus	32-36
29947534-10	2018	Vitamin D treatment also increased ET-1, ETBR and eNOS mRNA expressions.	Vitamin D	0-9	endothelin 1	Mus musculus	35-39
29947534-11	2018	Our in vitro study demonstrated Calcitriol induced ET-1 and eNOS mRNA expressions upregulation in HUVEC under normoxic and hypoxic condition.	Calcitriol	32-42	endothelin 1	Mus musculus	51-55
29947534-12	2018	Meanwhile, siRNA for ET-1 inhibited the upregulation of eNOS mRNA expression after Calcitriol treatment.	Calcitriol	83-93	endothelin 1	Mus musculus	21-25
29947534-13	2018	Vitamin D ameliorates kidney fibrosis through attenuating vascular remodeling and ischemia with upregulating ET-1/ETBR and eNOS expression.	Vitamin D	0-9	endothelin 1	Mus musculus	109-113
29947539-0	2018	Endothelial-derived endothelin-1 promotes pulmonary vascular remodeling in bleomycin-induced pulmonary fibrosis.	Bleomycin	75-84	endothelin 1	Mus musculus	20-32
29947539-8	2018	Compared to Wild type mice, bleomycin-induced VEETKO mice had lower ET-1 peptide levels (15.4 pg/mg vs. 31.2 pg/mg, p&lt;0.01).	Bleomycin	28-37	endothelin 1	Mus musculus	68-72
29947539-12	2018	In conclusion, endothelial-derived endothelin-1 promotes pulmonary vascular remodeling secondary to bleomycin-induced pulmonary fibrosis.	Bleomycin	100-109	endothelin 1	Mus musculus	35-47
29947543-0	2018	Endothelin-1 inhibition improves the mBDNF/proBDNF ratio in endothelial cells and HT22 neurons under high glucose/palmitate growth conditions.	Glucose	106-113	endothelin 1	Mus musculus	0-12
29947543-0	2018	Endothelin-1 inhibition improves the mBDNF/proBDNF ratio in endothelial cells and HT22 neurons under high glucose/palmitate growth conditions.	Palmitates	114-123	endothelin 1	Mus musculus	0-12
29658585-4	2018	The HSP90 inhibitors geldanamycin and 17-demethoxygeldanamycin (17-DMAG) significantly amplified HSP27 induction stimulated by ET-1 in a dose-dependent manner.	17-demethoxygeldanamycin	38-62	endothelin 1	Mus musculus	127-131
29316834-5	2018	ET-1 and ETB receptors were increased at 2-7 days after FPI, which was accompanied by extravasation of Evans blue (EB) and brain edema.	Evans Blue	103-113	endothelin 1	Mus musculus	0-4
29316834-5	2018	ET-1 and ETB receptors were increased at 2-7 days after FPI, which was accompanied by extravasation of Evans blue (EB) and brain edema.	Evans Blue	115-117	endothelin 1	Mus musculus	0-4
29947533-1	2018	The endothelin (ET) and prorenin/renin/prorenin receptor (PRR) systems have opposing physiological effects on collecting duct (CD) salt and water reabsorption.	Salts	131-135	endothelin 1	Mus musculus	4-14
29947533-1	2018	The endothelin (ET) and prorenin/renin/prorenin receptor (PRR) systems have opposing physiological effects on collecting duct (CD) salt and water reabsorption.	Water	140-145	endothelin 1	Mus musculus	4-14
29554596-6	2018	The treatment with quercetin also inhibited zymosan-induced depletion of reduced glutathione (GSH) levels, TNFalpha and IL-1beta production, and gp91phox, prepro-endothelin-1 (preproET-1), and cyclooxygenase-2 mRNA expression.	Quercetin	19-28	endothelin 1	Mus musculus	155-174
29554596-6	2018	The treatment with quercetin also inhibited zymosan-induced depletion of reduced glutathione (GSH) levels, TNFalpha and IL-1beta production, and gp91phox, prepro-endothelin-1 (preproET-1), and cyclooxygenase-2 mRNA expression.	Quercetin	19-28	endothelin 1	Mus musculus	176-186
29554596-6	2018	The treatment with quercetin also inhibited zymosan-induced depletion of reduced glutathione (GSH) levels, TNFalpha and IL-1beta production, and gp91phox, prepro-endothelin-1 (preproET-1), and cyclooxygenase-2 mRNA expression.	Zymosan	44-51	endothelin 1	Mus musculus	155-174
29554596-6	2018	The treatment with quercetin also inhibited zymosan-induced depletion of reduced glutathione (GSH) levels, TNFalpha and IL-1beta production, and gp91phox, prepro-endothelin-1 (preproET-1), and cyclooxygenase-2 mRNA expression.	Zymosan	44-51	endothelin 1	Mus musculus	176-186
29658585-4	2018	The HSP90 inhibitors geldanamycin and 17-demethoxygeldanamycin (17-DMAG) significantly amplified HSP27 induction stimulated by ET-1 in a dose-dependent manner.	17-(dimethylaminoethylamino)-17-demethoxygeldanamycin	64-71	endothelin 1	Mus musculus	127-131
29658585-5	2018	In addition, onalespib (another HSP90 inhibitor) significantly strengthened the ET-1-induced HSP27 protein levels.	(2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone	13-22	endothelin 1	Mus musculus	80-84
29658585-7	2018	Onalespib and 17-DMAG significantly enhanced the ET-1-induced phosphorylation of SAPK/JNK.	(2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone	0-9	endothelin 1	Mus musculus	49-53
29658585-7	2018	Onalespib and 17-DMAG significantly enhanced the ET-1-induced phosphorylation of SAPK/JNK.	17-(dimethylaminoethylamino)-17-demethoxygeldanamycin	14-21	endothelin 1	Mus musculus	49-53
29658585-8	2018	In addition, SP600125, a SAPK/JNK inhibitor, notably reduced the amplification by onalespib of ET-1-induced HSP27.	pyrazolanthrone	13-21	endothelin 1	Mus musculus	95-99
29658585-8	2018	In addition, SP600125, a SAPK/JNK inhibitor, notably reduced the amplification by onalespib of ET-1-induced HSP27.	(2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone	82-91	endothelin 1	Mus musculus	95-99
29756391-4	2018	We recently demonstrated that application of exogenous ET-1 increased NHE activity in murine PASMCs via a mechanism requiring Rho kinase (ROCK).	pasmcs	93-99	endothelin 1	Mus musculus	55-59
29485160-2	2018	Mice treated with a high concentration of Kuding tea polyphenols (HKTP) had lower serum levels of interleukin-6 (IL-6), IL-12, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), motilin (MOT), substance P (SP), and endothelin-1 (ET-1), and higher serum levels of somatostatin (SS) and vasoactive intestinal peptide (VIP) than did the mice in the control group.	Polyphenols	53-64	endothelin 1	Mus musculus	235-247
29363240-0	2018	Magnesium attenuates endothelin-1-induced vasoreactivity and enhances vasodilatation in mouse pulmonary arteries: Modulation by chronic hypoxic pulmonary hypertension.	Magnesium	0-9	endothelin 1	Mus musculus	21-33
29363240-14	2018	Our data showed that removal of extracellular magnesium suppressed vasoreactivity of PAs to both ET-1 and ACh.	Magnesium	46-55	endothelin 1	Mus musculus	97-101
29363240-14	2018	Our data showed that removal of extracellular magnesium suppressed vasoreactivity of PAs to both ET-1 and ACh.	Protactinium	85-88	endothelin 1	Mus musculus	97-101
29363240-15	2018	A high concentration of magnesium (4.8 mm) inhibited ET-1-induced vasoconstriction in endothelium-intact or endothelium-disrupted PAs of normoxic and CH-treated mice, and enhanced the ACh-induced production of NO in PAs of normoxic mice.	Magnesium	24-33	endothelin 1	Mus musculus	53-57
29363240-15	2018	A high concentration of magnesium (4.8 mm) inhibited ET-1-induced vasoconstriction in endothelium-intact or endothelium-disrupted PAs of normoxic and CH-treated mice, and enhanced the ACh-induced production of NO in PAs of normoxic mice.	Protactinium	130-133	endothelin 1	Mus musculus	53-57
29363240-17	2018	Hence, in this study we demonstrated that increasing the magnesium concentration can attenuate the ET-1-induced contractile response and improve vasodilatation via release of NO from the endothelium.	Magnesium	57-66	endothelin 1	Mus musculus	99-103
29353219-7	2018	When TSH levels declined to normal in these subjects after levothyroxine therapy, serum endothelin-1 levels were significantly reduced.	Thyroxine	59-72	endothelin 1	Mus musculus	88-100
29485160-2	2018	Mice treated with a high concentration of Kuding tea polyphenols (HKTP) had lower serum levels of interleukin-6 (IL-6), IL-12, tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), motilin (MOT), substance P (SP), and endothelin-1 (ET-1), and higher serum levels of somatostatin (SS) and vasoactive intestinal peptide (VIP) than did the mice in the control group.	hktp	66-70	endothelin 1	Mus musculus	235-247
29191928-6	2018	Costimulation of wild-type PASMCs with PDGF (platelet-derived growth factor) and the NEP substrate, ET-1 (endothelin-1), increased Rac and Rho activity, and decreased SM-protein levels mimicking the NEP knock-out phenotype.	pasmcs	27-33	endothelin 1	Mus musculus	100-104
29191928-6	2018	Costimulation of wild-type PASMCs with PDGF (platelet-derived growth factor) and the NEP substrate, ET-1 (endothelin-1), increased Rac and Rho activity, and decreased SM-protein levels mimicking the NEP knock-out phenotype.	pasmcs	27-33	endothelin 1	Mus musculus	106-118
29384055-6	2018	ET-1 activates the sphingosine kinase/sphingosine-1-phosphate (SphK/S1P) pathway.	sphingosine 1-phosphate	38-61	endothelin 1	Mus musculus	0-4
29996135-0	2018	Palmitic Acid Increases Endothelin-1 Expression in Vascular Endothelial Cells through the Induction of Endoplasmic Reticulum Stress and Protein Kinase C Signaling.	Palmitic Acid	0-13	endothelin 1	Mus musculus	24-36
29996135-6	2018	Moreover, the mRNA expression of ET-1 was significantly increased in cultured HAECs in response to acute (&lt; 24 h) and chronic (12-16 days) treatments with palmitic acid (PA), one of the most abundant saturated fatty acids in obesity.	Palmitic Acid	158-171	endothelin 1	Mus musculus	33-37
29996135-6	2018	Moreover, the mRNA expression of ET-1 was significantly increased in cultured HAECs in response to acute (&lt; 24 h) and chronic (12-16 days) treatments with palmitic acid (PA), one of the most abundant saturated fatty acids in obesity.	Palmitic Acid	173-175	endothelin 1	Mus musculus	33-37
29996135-6	2018	Moreover, the mRNA expression of ET-1 was significantly increased in cultured HAECs in response to acute (&lt; 24 h) and chronic (12-16 days) treatments with palmitic acid (PA), one of the most abundant saturated fatty acids in obesity.	Fatty Acids	203-224	endothelin 1	Mus musculus	33-37
29996135-7	2018	We found that the induction of ET-1 expression by PA was abolished by pretreating the cells with the endoplasmic reticulum (ER) stress inhibitor 4-phenylbutyric acid or the protein kinase C (PKC) inhibitor Go 6850.	Palmitic Acid	50-52	endothelin 1	Mus musculus	31-35
29996135-7	2018	We found that the induction of ET-1 expression by PA was abolished by pretreating the cells with the endoplasmic reticulum (ER) stress inhibitor 4-phenylbutyric acid or the protein kinase C (PKC) inhibitor Go 6850.	4-phenylbutyric acid	145-165	endothelin 1	Mus musculus	31-35
29996135-7	2018	We found that the induction of ET-1 expression by PA was abolished by pretreating the cells with the endoplasmic reticulum (ER) stress inhibitor 4-phenylbutyric acid or the protein kinase C (PKC) inhibitor Go 6850.	bisindolylmaleimide I	206-213	endothelin 1	Mus musculus	31-35
29996135-8	2018	CONCLUSION: Our findings demonstrate for the first time that PA increases ET-1 expression in endothelial cells through the induction of ER stress and the activation of PKC, providing novel mechanistic insights into the pathogenesis of obesity-associated hypertension and cardiovascular diseases.	Palmitic Acid	61-63	endothelin 1	Mus musculus	74-78
28515175-0	2017	Role for reactive oxygen species in flow-stimulated inner medullary collecting duct endothelin-1 production.	Reactive Oxygen Species	9-32	endothelin 1	Mus musculus	84-96
29870994-7	2018	Arteriolar O2 - was increased further by ET-1 and contractions to ET-1 reduced by PEG-SOD in both groups whereas H2O2 unchanged by ET-1 and contractions were reduced by PEG-catalase selectively in diabetic mice.	Oxygen	11-13	endothelin 1	Mus musculus	66-70
29870994-7	2018	Arteriolar O2 - was increased further by ET-1 and contractions to ET-1 reduced by PEG-SOD in both groups whereas H2O2 unchanged by ET-1 and contractions were reduced by PEG-catalase selectively in diabetic mice.	Polyethylene Glycols	82-85	endothelin 1	Mus musculus	41-45
29870994-7	2018	Arteriolar O2 - was increased further by ET-1 and contractions to ET-1 reduced by PEG-SOD in both groups whereas H2O2 unchanged by ET-1 and contractions were reduced by PEG-catalase selectively in diabetic mice.	Polyethylene Glycols	82-85	endothelin 1	Mus musculus	66-70
29870994-7	2018	Arteriolar O2 - was increased further by ET-1 and contractions to ET-1 reduced by PEG-SOD in both groups whereas H2O2 unchanged by ET-1 and contractions were reduced by PEG-catalase selectively in diabetic mice.	Polyethylene Glycols	82-85	endothelin 1	Mus musculus	66-70
29870994-9	2018	Sulindac normalized the Wnt signaling proteins, arteriolar O2 -, H2O2 and ET-1 contractions while doubling microvascular catalase and SOD2 expression in diabetic mice.	Sulindac	0-8	endothelin 1	Mus musculus	74-78
29870994-10	2018	CONCLUSION: Increased ROS, notably H2O2 contributes to enhanced afferent arteriolar responses to ET-1 in diabetes, which is closely associated with Wnt signaling.	Reactive Oxygen Species	22-25	endothelin 1	Mus musculus	97-101
29870994-10	2018	CONCLUSION: Increased ROS, notably H2O2 contributes to enhanced afferent arteriolar responses to ET-1 in diabetes, which is closely associated with Wnt signaling.	Hydrogen Peroxide	35-39	endothelin 1	Mus musculus	97-101
28807695-5	2017	In addition, the oxysterols not only induced the abca1 and abcg1 in HL-1 cells but also enhanced the expression of endothelin-1 and transforming growth factor-beta, which have already been identified as important factors in doxorubicin-induced cardiotoxicity.	Doxorubicin	224-235	endothelin 1	Mus musculus	115-163
28470405-0	2017	Arsenic-mediated hyperpigmentation in skin via NF-kappa B/endothelin-1 signaling in an originally developed hairless mouse model.	Arsenic	0-7	endothelin 1	Mus musculus	58-70
28470405-8	2017	Coexposure of primary normal human epithelial melanocytes to arsenic and ET-1 activated their proliferation and melanin synthesis with increased levels of MITF-M and ET-1 receptor expression.	Arsenic	61-68	endothelin 1	Mus musculus	166-170
28470405-9	2017	Our results suggest that interaction between keratinocytes and melanocytes in the skin through ET-1 and its receptor contributes to arsenic-mediated skin pigmentation, a hallmark of arsenicosis.	Arsenic	132-139	endothelin 1	Mus musculus	95-99
28575410-10	2017	In coronary arterioles from TAC mice, the endothelial nitric oxide (NO)-mediated dilation to acetylcholine (ACh) was reversed to vasoconstriction and the vasoconstriction to ET-1 was augmented.	Nitric Oxide	54-66	endothelin 1	Mus musculus	174-178
28575410-10	2017	In coronary arterioles from TAC mice, the endothelial nitric oxide (NO)-mediated dilation to acetylcholine (ACh) was reversed to vasoconstriction and the vasoconstriction to ET-1 was augmented.	Acetylcholine	93-106	endothelin 1	Mus musculus	174-178
28575410-11	2017	Inhibition of ROCK by H-1152 alleviated oxidative stress and abolished enhanced vasoconstriction to ET-1.	2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine	22-28	endothelin 1	Mus musculus	100-104
29870994-7	2018	Arteriolar O2 - was increased further by ET-1 and contractions to ET-1 reduced by PEG-SOD in both groups whereas H2O2 unchanged by ET-1 and contractions were reduced by PEG-catalase selectively in diabetic mice.	Oxygen	11-13	endothelin 1	Mus musculus	41-45
29870994-7	2018	Arteriolar O2 - was increased further by ET-1 and contractions to ET-1 reduced by PEG-SOD in both groups whereas H2O2 unchanged by ET-1 and contractions were reduced by PEG-catalase selectively in diabetic mice.	Oxygen	11-13	endothelin 1	Mus musculus	66-70
29089036-0	2017	Uric acid causes kidney injury through inducing fibroblast expansion, Endothelin-1 expression, and inflammation.	Uric Acid	0-9	endothelin 1	Mus musculus	70-82
29089036-17	2017	Determination of allopurinol attenuated kidney injury was based on reduction of fibroblast cell number, inflammation mediators and ppET-1 expression with reduction of TGF-beta1 and alpha-SMA protein expression.	Allopurinol	17-28	endothelin 1	Mus musculus	131-137
28515175-5	2017	Global NO synthase (NOS) inhibition [NG-nitro-l-arginine methyl ester (l-NAME)] reduced the ET-1 flow response; however, pharmacological inhibition of NOS1 or NOS2, inhibition of NOS3 siRNA, inhibition of arginase inhibition, removal of media l-Arg, or inhibition of NO-dependent signaling pathways (PKG, guanylyl cyclase, or NF-kappaB) did not affect the ET-1 flow response.	NG-Nitroarginine Methyl Ester	37-69	endothelin 1	Mus musculus	92-96
28515175-5	2017	Global NO synthase (NOS) inhibition [NG-nitro-l-arginine methyl ester (l-NAME)] reduced the ET-1 flow response; however, pharmacological inhibition of NOS1 or NOS2, inhibition of NOS3 siRNA, inhibition of arginase inhibition, removal of media l-Arg, or inhibition of NO-dependent signaling pathways (PKG, guanylyl cyclase, or NF-kappaB) did not affect the ET-1 flow response.	NG-Nitroarginine Methyl Ester	71-77	endothelin 1	Mus musculus	92-96
28515175-5	2017	Global NO synthase (NOS) inhibition [NG-nitro-l-arginine methyl ester (l-NAME)] reduced the ET-1 flow response; however, pharmacological inhibition of NOS1 or NOS2, inhibition of NOS3 siRNA, inhibition of arginase inhibition, removal of media l-Arg, or inhibition of NO-dependent signaling pathways (PKG, guanylyl cyclase, or NF-kappaB) did not affect the ET-1 flow response.	NG-Nitroarginine Methyl Ester	71-77	endothelin 1	Mus musculus	356-360
28515175-5	2017	Global NO synthase (NOS) inhibition [NG-nitro-l-arginine methyl ester (l-NAME)] reduced the ET-1 flow response; however, pharmacological inhibition of NOS1 or NOS2, inhibition of NOS3 siRNA, inhibition of arginase inhibition, removal of media l-Arg, or inhibition of NO-dependent signaling pathways (PKG, guanylyl cyclase, or NF-kappaB) did not affect the ET-1 flow response.	Arginine	243-248	endothelin 1	Mus musculus	92-96
28515175-10	2017	Taken together, these data suggest that NOX4-derived ROS in general, and possibly superoxide in particular, are involved in flow-stimulated IMCD ET-1 production.	Reactive Oxygen Species	53-56	endothelin 1	Mus musculus	145-149
28515175-10	2017	Taken together, these data suggest that NOX4-derived ROS in general, and possibly superoxide in particular, are involved in flow-stimulated IMCD ET-1 production.	Superoxides	82-92	endothelin 1	Mus musculus	145-149
28539637-6	2017	The combined down-regulation of ETBR and ET1 had no additional anxiogenic effect compared to knocking down the ETBR gene alone, suggesting that BLA ET1 acts through ETBRs to regulate anxiety-like behaviors.	etbrs	165-170	endothelin 1	Mus musculus	148-151
28704616-4	2017	Systemically administered endothelin-1 (ET-1) or bradykinin (BK) inhibited platelet aggregation in a similar fashion in 8- to 10-week-old ApoE-/- and WT mice, but not in the ApoE-/- mice at 18-20 weeks of age, although both peptides maintained their capacity to increase plasma levels of the PGI2.	Epoprostenol	292-296	endothelin 1	Mus musculus	26-38
28234672-8	2017	N(omega)-Nitro-L-arginine methyl ester abrogated relaxation responses, and the Ednra/Ednrb mRNA ratio was decreased in eET-1/smPpargamma-/-, which could indicate that nitric oxide production was enhanced by ET-1 stimulation of endothelin type B receptors.	Nitric Oxide	167-179	endothelin 1	Mus musculus	120-124
28234672-15	2017	Paradoxically, ET-1 overexpression preserved endothelial function in smPpargamma-/- mice, presumably by enhancing nitric oxide through stimulation of endothelin type B receptors.	Nitric Oxide	114-126	endothelin 1	Mus musculus	15-19
28342550-4	2017	Using calcium imaging we found that SGCs in intact, freshly isolated NG and Sup-CG are highly sensitive to ET-1, with threshold concentration at 0.1nM.	Calcium	6-13	endothelin 1	Mus musculus	107-111
28450948-6	2017	Furthermore, FCQS was also able to increase the serum levels of motilin, endothelin-1, vasoactive intestinal peptide and acetylcholinesterase compared with the control group.	fcqs	13-17	endothelin 1	Mus musculus	73-85
28216625-12	2017	However, if comorbid with obesity, endothelin-1-modulated, prostanoid-mediated renal arterial dysfunction becomes apparent.	Prostaglandins	59-69	endothelin 1	Mus musculus	35-47
28120456-7	2017	Because vitamin D-induced hypercalcaemia increases the renal expression of endothelin (ET)-1, we hypothesized that ET-1 mediates the effects of hypercalcaemia on renal sodium and water handling.	Vitamin D	8-17	endothelin 1	Mus musculus	75-92
28120456-7	2017	Because vitamin D-induced hypercalcaemia increases the renal expression of endothelin (ET)-1, we hypothesized that ET-1 mediates the effects of hypercalcaemia on renal sodium and water handling.	Sodium	168-174	endothelin 1	Mus musculus	75-92
27701898-1	2017	The present study investigated whether endothelin-1 acts via ETA or ETB receptors to mediate superoxide anion-induced pain and inflammation.	Superoxides	93-109	endothelin 1	Mus musculus	39-51
27894808-10	2017	BA ameliorated the reduction of endothelial nitric oxide synthase (eNOS) expression, leading to the inhibition of intracellular adhesion molecule 1 (ICAM-1) and endothelin 1 (ET-1) expression.	betulinic acid	0-2	endothelin 1	Mus musculus	161-173
27894808-10	2017	BA ameliorated the reduction of endothelial nitric oxide synthase (eNOS) expression, leading to the inhibition of intracellular adhesion molecule 1 (ICAM-1) and endothelin 1 (ET-1) expression.	betulinic acid	0-2	endothelin 1	Mus musculus	175-179
29216624-7	2017	Aortic rings from ApoE-/- mice also exhibited enhanced contractions to ET-1 (Rmax ~30%, p&lt;0.01), which were attenuated in sildenafil-treated ApoE-/- mice.	Sildenafil Citrate	125-135	endothelin 1	Mus musculus	71-75
27919002-1	2017	BACKGROUND: Our previous study showed that the mu-opioid receptor agonist fentanyl citrate inhibits endothelin-1-and bradykinin-mediated pain responses in mice orthotopically inoculated with melanoma cells.	Fentanyl	74-90	endothelin 1	Mus musculus	100-113
27919002-4	2017	Thus, the present study was conducted to determine whether fentanyl citrate affects bradykinin-induced endothelin-1 secretion in B16-BL6 melanoma cells.	Fentanyl	59-75	endothelin 1	Mus musculus	103-115
27919002-7	2017	RESULTS: Fentanyl citrate inhibited bradykinin-induced endothelin-1 secretion.	Fentanyl	9-25	endothelin 1	Mus musculus	55-67
27919002-8	2017	The inhibitory effect of fentanyl citrate on the secretion of endothelin-1 was attenuated by the mu-opioid receptor antagonist naloxone methiodide.	Fentanyl	25-41	endothelin 1	Mus musculus	62-74
27919002-8	2017	The inhibitory effect of fentanyl citrate on the secretion of endothelin-1 was attenuated by the mu-opioid receptor antagonist naloxone methiodide.	N-methylnaloxone	127-146	endothelin 1	Mus musculus	62-74
27919002-10	2017	CONCLUSION: These results suggest that fentanyl citrate regulates bradykinin-induced endothelin-1 secretion through mu-opioid receptors in melanoma cells.	Fentanyl	39-55	endothelin 1	Mus musculus	85-97
27612006-10	2017	In SS mouse lung or in hemin-treated HPAECs, activation of PPARgamma with RSG attenuated reductions in PPARgamma and increases in miR-27a, ET-1, and markers of endothelial dysfunction.	Rosiglitazone	74-77	endothelin 1	Mus musculus	139-143
27905299-3	2016	This study tested the hypothesis that blunting the vascular influence of ET-1, either through endothelin ETA receptor blockade (ABT-627) or vascular endothelial cell deletion of ET-1 (VEET KO), would improve recovery of renal perfusion and repair of injury following a severe ischemic insult in mice (45 min unilateral renal ischemia).	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	128-131	endothelin 1	Mus musculus	73-77
27640146-7	2016	ET-1-treated PbN-infected mice exhibited neurological signs, hypothermia, and behavioral alterations characteristic of ECM, dying 4 to 8 dpi.	3-aminodiphenyleneiodium	137-140	endothelin 1	Mus musculus	0-4
27496868-9	2016	CONCLUSIONS: Stimulation of IP3Rs with ET-1 induces Ca(2+ )release from the SR which is tunnelled to mitochondria via mitochondrial RyR leading to stimulation of mitochondrial ATP production.	Adenosine Triphosphate	176-179	endothelin 1	Mus musculus	39-43
27573019-6	2016	Tubacin, an inhibitor of HDAC6, antagonized PlGF-mediated repression of DNM3os/pre-miR-199a2 transcription with a concomitant reduction in ET-1 levels in cultured endothelial cells.	tubacin	0-7	endothelin 1	Mus musculus	139-143
27573019-8	2016	Delivery of tubacin to BK-SS mice significantly attenuated plasma ET-1 and PlGF levels.	tubacin	12-19	endothelin 1	Mus musculus	66-70
27496868-5	2016	Both ET-1 and isoproterenol induced an increase in mitochondrial Ca(2+ )(Ca(2 +) m) but only ET-1 led to an increase in ATP concentration.	Adenosine Triphosphate	120-123	endothelin 1	Mus musculus	93-97
27760895-7	2016	Moreover, endophilin A2 increase VSMCs proliferation induced by endothelin-1 or hypo-osmolarity.	vsmcs	33-38	endothelin 1	Mus musculus	64-76
26883974-8	2016	HT22 cells synthesize high levels of ET-1 in normal conditions, which was reduced with palmitate and bosentan as well as low and high glucose conditions.	Palmitates	87-96	endothelin 1	Mus musculus	37-41
27062279-11	2016	In P1 arteries, constriction to thrombin or A23187 was inhibited by endothelial-denudation, by ET-1 receptor antagonists (BQ123 plus BQ788) or by inhibition of endothelin-converting enzyme (phosphoramidon or SM19712).	Calcimycin	44-50	endothelin 1	Mus musculus	95-99
27496868-6	2016	ET-1-induced effects were prevented by cell treatment with the IP3 antagonist 2-aminoethoxydiphenyl borate and absent in myocytes from transgenic mice expressing an IP3 chelating protein (IP3 sponge).	Inositol 1,4,5-Trisphosphate	63-66	endothelin 1	Mus musculus	0-4
27496868-6	2016	ET-1-induced effects were prevented by cell treatment with the IP3 antagonist 2-aminoethoxydiphenyl borate and absent in myocytes from transgenic mice expressing an IP3 chelating protein (IP3 sponge).	2-aminoethoxydiphenyl borate	78-106	endothelin 1	Mus musculus	0-4
27496868-6	2016	ET-1-induced effects were prevented by cell treatment with the IP3 antagonist 2-aminoethoxydiphenyl borate and absent in myocytes from transgenic mice expressing an IP3 chelating protein (IP3 sponge).	Inositol 1,4,5-Trisphosphate	165-168	endothelin 1	Mus musculus	0-4
27496868-6	2016	ET-1-induced effects were prevented by cell treatment with the IP3 antagonist 2-aminoethoxydiphenyl borate and absent in myocytes from transgenic mice expressing an IP3 chelating protein (IP3 sponge).	Inositol 1,4,5-Trisphosphate	165-168	endothelin 1	Mus musculus	0-4
27496868-7	2016	Furthermore, ET-1-induced mitochondrial Ca(2+) uptake was insensitive to the mitochondrial Ca(2+ )uniporter inhibitor Ru360, however was attenuated by RyRs type 1 inhibitor dantrolene.	Dantrolene	173-183	endothelin 1	Mus musculus	13-17
26883974-8	2016	HT22 cells synthesize high levels of ET-1 in normal conditions, which was reduced with palmitate and bosentan as well as low and high glucose conditions.	Bosentan	101-109	endothelin 1	Mus musculus	37-41
26883974-8	2016	HT22 cells synthesize high levels of ET-1 in normal conditions, which was reduced with palmitate and bosentan as well as low and high glucose conditions.	Glucose	134-141	endothelin 1	Mus musculus	37-41
26883974-9	2016	Decreased ET-1 levels were associated with greater activation of NLRP3 and IL-1beta in normal glucose.	Glucose	94-101	endothelin 1	Mus musculus	10-14
26546722-1	2016	AIMS: Endothelin-1 (ET-1) is an autocrine inhibitor of collecting duct (CD) Na(+) and water reabsorption.	Water	86-91	endothelin 1	Mus musculus	6-18
27280426-1	2016	The collecting duct endothelin-1 (ET-1), endothelin B (ETB) receptor, and nitric oxide synthase-1 (NOS1) pathways are critical for regulation of fluid-electrolyte balance and blood pressure control during high-salt feeding.	Salts	210-214	endothelin 1	Mus musculus	20-32
26546722-1	2016	AIMS: Endothelin-1 (ET-1) is an autocrine inhibitor of collecting duct (CD) Na(+) and water reabsorption.	Water	86-91	endothelin 1	Mus musculus	20-24
26546722-2	2016	CD ET-1 production is increased by a high salt diet and is important in promoting a natriuretic response.	Salts	42-46	endothelin 1	Mus musculus	3-7
26546722-3	2016	The mechanisms by which a high salt diet enhances CD ET-1 are being uncovered.	Salts	31-35	endothelin 1	Mus musculus	53-57
26546722-4	2016	In particular, elevated tubule fluid flow, as occurs in salt loading, enhances CD ET-1 synthesis.	Salts	56-60	endothelin 1	Mus musculus	82-86
26546722-7	2016	KEY FINDINGS: Flow or hyperosmolality (using NaCl, mannitol or urea) individually caused an ~2-fold increase in ET-1 mRNA, while flow and hyperosmolality together increased ET-1 mRNA by ~14 fold.	Sodium Chloride	45-49	endothelin 1	Mus musculus	112-116
26546722-7	2016	KEY FINDINGS: Flow or hyperosmolality (using NaCl, mannitol or urea) individually caused an ~2-fold increase in ET-1 mRNA, while flow and hyperosmolality together increased ET-1 mRNA by ~14 fold.	Mannitol	51-59	endothelin 1	Mus musculus	112-116
26546722-7	2016	KEY FINDINGS: Flow or hyperosmolality (using NaCl, mannitol or urea) individually caused an ~2-fold increase in ET-1 mRNA, while flow and hyperosmolality together increased ET-1 mRNA by ~14 fold.	Urea	63-67	endothelin 1	Mus musculus	112-116
26546722-11	2016	These findings may be relevant to explaining high salt diet induction of CD ET-1 production.	Salts	50-54	endothelin 1	Mus musculus	76-80
27102411-0	2016	c-Src tyrosine kinase mediates high glucose-induced endothelin-1 expression.	Glucose	36-43	endothelin 1	Mus musculus	52-64
27189971-4	2016	GW0742 prevented the increase in both arterial blood pressure and plasma noradrenaline levels and the higher reduction of blood pressure after ganglionic blockade, whereas it reduced the mesenteric arterial remodeling and the hyper-responsiveness to vasoconstrictors (AngII and endothelin-1) in AngII-infused mice.	GW0742	0-6	endothelin 1	Mus musculus	278-290
26775567-0	2016	Aldosterone alters the chromatin structure of the murine endothelin-1 gene.	Aldosterone	0-11	endothelin 1	Mus musculus	57-69
26775567-2	2016	Paradoxically, aldosterone also induces transcription of the endothelin-1 (Edn1) gene to increase protein (ET-1) levels, which inhibits sodium reabsorption.	Aldosterone	15-26	endothelin 1	Mus musculus	61-73
26775567-2	2016	Paradoxically, aldosterone also induces transcription of the endothelin-1 (Edn1) gene to increase protein (ET-1) levels, which inhibits sodium reabsorption.	Aldosterone	15-26	endothelin 1	Mus musculus	75-79
26775567-2	2016	Paradoxically, aldosterone also induces transcription of the endothelin-1 (Edn1) gene to increase protein (ET-1) levels, which inhibits sodium reabsorption.	Aldosterone	15-26	endothelin 1	Mus musculus	107-111
26775567-2	2016	Paradoxically, aldosterone also induces transcription of the endothelin-1 (Edn1) gene to increase protein (ET-1) levels, which inhibits sodium reabsorption.	Sodium	136-142	endothelin 1	Mus musculus	61-73
26775567-2	2016	Paradoxically, aldosterone also induces transcription of the endothelin-1 (Edn1) gene to increase protein (ET-1) levels, which inhibits sodium reabsorption.	Sodium	136-142	endothelin 1	Mus musculus	75-79
26775567-2	2016	Paradoxically, aldosterone also induces transcription of the endothelin-1 (Edn1) gene to increase protein (ET-1) levels, which inhibits sodium reabsorption.	Sodium	136-142	endothelin 1	Mus musculus	107-111
26775567-3	2016	AIMS: Here we investigated changes in the chromatin structure of the Edn1 gene of collecting duct cell lines in response to aldosterone treatment.	Aldosterone	124-135	endothelin 1	Mus musculus	69-73
26791973-2	2016	Nitric oxide (NO) deficiency increases endothelin-1 (ET-1) production, and this increased ET-1 may contribute to the pathophysiology of NO deficiency-induced FGR.	Nitric Oxide	0-12	endothelin 1	Mus musculus	39-51
26791973-2	2016	Nitric oxide (NO) deficiency increases endothelin-1 (ET-1) production, and this increased ET-1 may contribute to the pathophysiology of NO deficiency-induced FGR.	Nitric Oxide	0-12	endothelin 1	Mus musculus	53-57
26791973-2	2016	Nitric oxide (NO) deficiency increases endothelin-1 (ET-1) production, and this increased ET-1 may contribute to the pathophysiology of NO deficiency-induced FGR.	Nitric Oxide	0-12	endothelin 1	Mus musculus	90-94
27190058-7	2016	Inhibition of PICK1 by using FSC231 abolished ET-1-induced and ionomycin-induced NFATc3 nuclear import, but it did not alter ET-1-mediated Ca(2+) responses, suggesting that PICK1 acts downstream of Ca(2+) influx.	FSC 231	29-35	endothelin 1	Mus musculus	46-50
27102411-4	2016	In this study, we aimed to elucidate whether high glucose-activated c-Src signaling plays a role in the regulation of ET-1 expression.	Glucose	50-57	endothelin 1	Mus musculus	118-122
27102411-10	2016	Chemical inhibition or silencing of c-Src significantly decreased the high-glucose augmented ET-1 expression in cultured ECs.	Glucose	75-82	endothelin 1	Mus musculus	93-97
26769087-2	2016	Interestingly, oral administration of dietary raffinose family oligosaccharides (RFOs) at 400 and 800 mg/kg bw significantly reduced the impact of l-carnitine on the serum total cholesterol, triglycerides, high- and low-density lipoproteins, alanine aminotransferase, aspartate amino-transferase, NO, endothelin-1 and C-reactive protein.	Raffinose	46-55	endothelin 1	Mus musculus	301-313
26961876-5	2016	Our results support this novel concept based on attenuated scratching behavior in response to histaminergic (histamine, compound 48/80, endothelin-1), not non-histaminergic (chloroquine) pruritogens in Trpv4 keratinocyte-specific and inducible knock-out mice.	Histamine	94-103	endothelin 1	Mus musculus	136-148
27082116-9	2016	In particular, our data show that the involvement of endothelin-1 pathway in thyroxine-induced cardiac hypertrophy/dysfunction seems to be model-dependent and should be carefully interpreted.	Thyroxine	77-86	endothelin 1	Mus musculus	53-65
26769087-2	2016	Interestingly, oral administration of dietary raffinose family oligosaccharides (RFOs) at 400 and 800 mg/kg bw significantly reduced the impact of l-carnitine on the serum total cholesterol, triglycerides, high- and low-density lipoproteins, alanine aminotransferase, aspartate amino-transferase, NO, endothelin-1 and C-reactive protein.	Oligosaccharides	63-79	endothelin 1	Mus musculus	301-313
26769087-2	2016	Interestingly, oral administration of dietary raffinose family oligosaccharides (RFOs) at 400 and 800 mg/kg bw significantly reduced the impact of l-carnitine on the serum total cholesterol, triglycerides, high- and low-density lipoproteins, alanine aminotransferase, aspartate amino-transferase, NO, endothelin-1 and C-reactive protein.	rfos	81-85	endothelin 1	Mus musculus	301-313
26653747-0	2016	Potentiation of endothelin-1-induced prostaglandin E2 formation by Ni(2+) and Sr(2+) in murine osteoblastic MC3T3-E1 cells.	Dinoprostone	37-53	endothelin 1	Mus musculus	16-28
26568405-5	2016	This study investigates the effect of methamphetamine on endothelin-1 (ET-1) release in mouse brain endothelial cells by ELISA.	Methamphetamine	38-53	endothelin 1	Mus musculus	57-69
26568405-5	2016	This study investigates the effect of methamphetamine on endothelin-1 (ET-1) release in mouse brain endothelial cells by ELISA.	Methamphetamine	38-53	endothelin 1	Mus musculus	71-75
26568405-10	2016	Methamphetamine treatment of mouse brain endothelial cells resulted in ET-1 release and a transient increase in ET-1 message.	Methamphetamine	0-15	endothelin 1	Mus musculus	71-75
26568405-10	2016	Methamphetamine treatment of mouse brain endothelial cells resulted in ET-1 release and a transient increase in ET-1 message.	Methamphetamine	0-15	endothelin 1	Mus musculus	112-116
26561980-0	2016	Endothelin-1 contributes to  the progression of renal injury  in sickle cell disease via reactive  oxygen species.	Reactive Oxygen Species	89-113	endothelin 1	Mus musculus	0-12
26810570-3	2016	Pre-treatment of mice with TA (25 or 50 g/kg/day) significantly ameliorated hepatic morphology and coefficient values and reduced the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), the concentrations of malondialdehyde (MDA) and serum levels of endothelin-1 (ET-1).	Tannins	27-29	endothelin 1	Mus musculus	281-293
26653747-0	2016	Potentiation of endothelin-1-induced prostaglandin E2 formation by Ni(2+) and Sr(2+) in murine osteoblastic MC3T3-E1 cells.	Nickel(2+)	67-73	endothelin 1	Mus musculus	16-28
26653747-0	2016	Potentiation of endothelin-1-induced prostaglandin E2 formation by Ni(2+) and Sr(2+) in murine osteoblastic MC3T3-E1 cells.	strontium cation	78-84	endothelin 1	Mus musculus	16-28
26653747-3	2016	In this study we have demonstrated, that Ni(2+) and Sr(2+) potentiate endothelin-1 induced prostaglandin E2 formation in the osteoblastic cell line, MC3T3-E1, even in the absence of extracellular calcium.	Nickel(2+)	41-47	endothelin 1	Mus musculus	70-82
26653747-3	2016	In this study we have demonstrated, that Ni(2+) and Sr(2+) potentiate endothelin-1 induced prostaglandin E2 formation in the osteoblastic cell line, MC3T3-E1, even in the absence of extracellular calcium.	strontium cation	52-58	endothelin 1	Mus musculus	70-82
26653747-3	2016	In this study we have demonstrated, that Ni(2+) and Sr(2+) potentiate endothelin-1 induced prostaglandin E2 formation in the osteoblastic cell line, MC3T3-E1, even in the absence of extracellular calcium.	Dinoprostone	91-107	endothelin 1	Mus musculus	70-82
26400543-2	2015	Aldosterone also stimulates endothelin-1 (ET-1) production that acts within the CD to inhibit Na reabsorption via a negative feedback mechanism.	Cadmium	80-82	endothelin 1	Mus musculus	28-40
26539823-10	2015	In the CCl4 model, 9 weeks treatment with BAR501 effectively protected against development of endothelial dysfunction by increasing liver CSE expression and activity and by reducing endothelin (ET)-1 gene expression.	6-ethyl-3,7-dihydroxycholan-24-ol	42-48	endothelin 1	Mus musculus	182-199
27832660-1	2016	BACKGROUND/AIMS: ET-1 has independent effects on blood pressure regulation in vivo, it is involved in tubular water and salt excretion, promotes constriction of smooth muscle cells, modulates sympathetic nerve activity, and activates the liberation of nitric oxide.	Water	110-115	endothelin 1	Mus musculus	17-21
27832660-1	2016	BACKGROUND/AIMS: ET-1 has independent effects on blood pressure regulation in vivo, it is involved in tubular water and salt excretion, promotes constriction of smooth muscle cells, modulates sympathetic nerve activity, and activates the liberation of nitric oxide.	Salts	120-124	endothelin 1	Mus musculus	17-21
27832660-1	2016	BACKGROUND/AIMS: ET-1 has independent effects on blood pressure regulation in vivo, it is involved in tubular water and salt excretion, promotes constriction of smooth muscle cells, modulates sympathetic nerve activity, and activates the liberation of nitric oxide.	Nitric Oxide	252-264	endothelin 1	Mus musculus	17-21
26400543-2	2015	Aldosterone also stimulates endothelin-1 (ET-1) production that acts within the CD to inhibit Na reabsorption via a negative feedback mechanism.	Cadmium	80-82	endothelin 1	Mus musculus	42-46
26400543-3	2015	We tested the hypothesis that this renal aldosterone-endothelin feedback system regulates electrolyte balance and BP by comparing the effect of a high-salt (NaCl) diet and mineralocorticoid stimulation in control and CD-specific ET-1 knockout (CD ET-1 KO) mice.	Cadmium	217-219	endothelin 1	Mus musculus	229-233
26400543-5	2015	CD ET-1 KO mice consumed more high-salt diet and saline and had greater urine output than controls.	Salts	35-39	endothelin 1	Mus musculus	3-7
26400543-5	2015	CD ET-1 KO mice consumed more high-salt diet and saline and had greater urine output than controls.	Sodium Chloride	49-55	endothelin 1	Mus musculus	3-7
26400543-6	2015	CD ET-1 KO mice exhibited increased BP and greater fluid retention and body weight than controls on a high-salt diet.	Salts	107-111	endothelin 1	Mus musculus	3-7
26400543-7	2015	DOCP with high-salt feeding further increased BP in CD ET-1 KO mice, and by the end of the study the CD ET-1 KO mice were substantially hypernatremic.	deoxycortone pivalate	0-4	endothelin 1	Mus musculus	55-59
26400543-7	2015	DOCP with high-salt feeding further increased BP in CD ET-1 KO mice, and by the end of the study the CD ET-1 KO mice were substantially hypernatremic.	deoxycortone pivalate	0-4	endothelin 1	Mus musculus	104-108
26400543-9	2015	We conclude that local ET-1 production in the CD is required for the appropriate renal response to Na loading and that lack of local ET-1 results in abnormal fluid and electrolyte handling when challenged with a high-salt diet and with DOCP treatment.	Cadmium	46-48	endothelin 1	Mus musculus	23-27
26400543-9	2015	We conclude that local ET-1 production in the CD is required for the appropriate renal response to Na loading and that lack of local ET-1 results in abnormal fluid and electrolyte handling when challenged with a high-salt diet and with DOCP treatment.	deoxycortone pivalate	236-240	endothelin 1	Mus musculus	133-137
26246053-9	2015	Finally, we demonstrated that intraplantar injection of potassium superoxide induces the mRNA expression of prepro-endothelin-1 in the paw skin and spinal cord.	potassium superoxide	56-76	endothelin 1	Mus musculus	115-127
26101346-3	2015	We now generated a tamoxifen-inducible endothelium-restricted EDN1 overexpressing transgenic mouse (ieET-1) using Cre/loxP technology.	Tamoxifen	19-28	endothelin 1	Mus musculus	62-66
26460070-12	2015	Our studies provide a potential therapeutic approach whereby fenofibrate-induced miR-301a/miR-454 expression can ameliorate PH and lung fibrosis by reduction in ET-1 and PAI-1 levels in SCD.	Fenofibrate	61-72	endothelin 1	Mus musculus	161-165
26104290-2	2015	Our transgenic mice with ET-1 overexpression in the endothelial cells (TET-1) showed more severe blood-brain barrier (BBB) breakdown, neuronal apoptosis, and glial reactivity after 2-hour transient middle cerebral artery occlusion (tMCAO) with 22-hour reperfusion and more severe cognitive deficits after 30 minutes tMCAO with 5 months reperfusion.	tmcao	232-237	endothelin 1	Mus musculus	25-29
26104290-2	2015	Our transgenic mice with ET-1 overexpression in the endothelial cells (TET-1) showed more severe blood-brain barrier (BBB) breakdown, neuronal apoptosis, and glial reactivity after 2-hour transient middle cerebral artery occlusion (tMCAO) with 22-hour reperfusion and more severe cognitive deficits after 30 minutes tMCAO with 5 months reperfusion.	tmcao	316-321	endothelin 1	Mus musculus	25-29
25660617-2	2015	In a murine doxorubicin cardiotoxicity model, increased endothelin-1 (ET-1) expression and cardioprotective effects of the dual ET-1 blocker bosentan were demonstrated.	Doxorubicin	12-23	endothelin 1	Mus musculus	56-68
25733239-2	2015	Because activation of thromboxane prostanoid receptors (TP-Rs) can generate ROS, which can generate ET-1, we tested the hypothesis that chronic kidney disease induces cyclooxygenase-2 whose products activate TP-Rs to enhance ET-1 and ROS generation and contractions.	Reactive Oxygen Species	76-79	endothelin 1	Mus musculus	100-104
25733239-8	2015	RRM doubled the ET-1-induced cellular and mitochondrial ROS generation (P&lt;0.05).	Reactive Oxygen Species	56-59	endothelin 1	Mus musculus	16-20
25733239-10	2015	In conclusion, RRM leads to microvascular remodeling and enhanced ET-1-induced cellular and mitochondrial ROS and contractions that are mediated by cyclooxygenase-2 products activating TP-Rs.	Reactive Oxygen Species	106-109	endothelin 1	Mus musculus	66-70
25848038-0	2015	Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade.	Superoxides	56-66	endothelin 1	Mus musculus	0-12
25848038-9	2015	We conclude that endothelin-1 is critical for maintaining normal contractile function, for controlling superoxide and Mmp9 levels, and for ensuring that the myocardium has sufficient collagen to prevent overstretching.	Superoxides	103-113	endothelin 1	Mus musculus	17-29
25659899-5	2015	ET-1 increased superoxide production and the detection of protoporphyrin IX fluorescence, suggesting oxidant conditions might impair heme biosynthesis by ferrochelatase.	Heme	133-137	endothelin 1	Mus musculus	0-4
25587122-1	2015	Collecting duct-derived endothelin (ET)-1 is an autocrine inhibitor of Na(+) and water reabsorption; its deficiency causes hypertension and water retention.	Water	81-86	endothelin 1	Mus musculus	24-41
25587122-1	2015	Collecting duct-derived endothelin (ET)-1 is an autocrine inhibitor of Na(+) and water reabsorption; its deficiency causes hypertension and water retention.	Water	140-145	endothelin 1	Mus musculus	24-41
25564230-6	2015	Simvastatin restored baseline levels of nitric oxide (NO), NO-, and KATP channel-mediated dilations and endothelin-1-induced contractions.	Simvastatin	0-11	endothelin 1	Mus musculus	104-116
25934765-5	2015	We found that a omega-3 fatty acid diet: (i) normalizes red cell membrane omega-6/omega-3 ratio; (ii) reduces neutrophil count; (iii) decreases endothelial activation by targeting endothelin-1 and (iv) improves left ventricular outflow tract dimensions.	Fatty Acids, Omega-3	16-34	endothelin 1	Mus musculus	180-192
25934765-5	2015	We found that a omega-3 fatty acid diet: (i) normalizes red cell membrane omega-6/omega-3 ratio; (ii) reduces neutrophil count; (iii) decreases endothelial activation by targeting endothelin-1 and (iv) improves left ventricular outflow tract dimensions.	Fatty Acids, Omega-3	16-23	endothelin 1	Mus musculus	180-192
25572710-12	2015	As expected, TNF-alpha increased ET-1 and ETA expression in a dose-dependent manner; furthermore, application of the TNF-alpha inhibitor CAY10500 partially inhibited hypoxia-induced ET-1 and ETA expression.	cay10500	137-145	endothelin 1	Mus musculus	33-37
25572710-12	2015	As expected, TNF-alpha increased ET-1 and ETA expression in a dose-dependent manner; furthermore, application of the TNF-alpha inhibitor CAY10500 partially inhibited hypoxia-induced ET-1 and ETA expression.	cay10500	137-145	endothelin 1	Mus musculus	182-186
25659899-3	2015	ALA treatment of BPA attenuated ET-1-induced increases in mitochondrial superoxide (detected by MitoSox), STAT3 phosphorylation, and decreases in miR204 and SOD2 expression.	Aminolevulinic Acid	0-3	endothelin 1	Mus musculus	32-36
25659899-3	2015	ALA treatment of BPA attenuated ET-1-induced increases in mitochondrial superoxide (detected by MitoSox), STAT3 phosphorylation, and decreases in miR204 and SOD2 expression.	bisphenol A	17-20	endothelin 1	Mus musculus	32-36
25659899-3	2015	ALA treatment of BPA attenuated ET-1-induced increases in mitochondrial superoxide (detected by MitoSox), STAT3 phosphorylation, and decreases in miR204 and SOD2 expression.	Superoxides	72-82	endothelin 1	Mus musculus	32-36
25659899-4	2015	Because ALA increases BPA protoporphyrin IX (a stimulator of guanylate cyclase) and cGMP-mediated protein kinase G (PKG) activity, the effects of the PKG activator 8-bromo-cGMP were examined and found to also attenuate the ET-1-induced increase in superoxide.	Aminolevulinic Acid	8-11	endothelin 1	Mus musculus	223-227
25659899-5	2015	ET-1 increased superoxide production and the detection of protoporphyrin IX fluorescence, suggesting oxidant conditions might impair heme biosynthesis by ferrochelatase.	Superoxides	15-25	endothelin 1	Mus musculus	0-4
25659899-5	2015	ET-1 increased superoxide production and the detection of protoporphyrin IX fluorescence, suggesting oxidant conditions might impair heme biosynthesis by ferrochelatase.	protoporphyrin IX	58-75	endothelin 1	Mus musculus	0-4
25667044-5	2015	For similar affinities, rmMCP-4 showed a higher activity toward the fluorogenic substrate and a higher ability to process Big ET-1 as compared to recombinant CMA1 (chymase activity (kcat/KM in muM(-1)s(-1)): 2.29 x 10(-4)vs. 6.41 x 10(-6); ET-1 (1-31) production: 2.19 x 10(-3)vs. 6.57 x 10(-5)), and both of these activities of mouse and human chymase were sensitive to TY-51469.	rmmcp-4	24-31	endothelin 1	Mus musculus	126-130
25667044-5	2015	For similar affinities, rmMCP-4 showed a higher activity toward the fluorogenic substrate and a higher ability to process Big ET-1 as compared to recombinant CMA1 (chymase activity (kcat/KM in muM(-1)s(-1)): 2.29 x 10(-4)vs. 6.41 x 10(-6); ET-1 (1-31) production: 2.19 x 10(-3)vs. 6.57 x 10(-5)), and both of these activities of mouse and human chymase were sensitive to TY-51469.	rmmcp-4	24-31	endothelin 1	Mus musculus	240-244
25660617-2	2015	In a murine doxorubicin cardiotoxicity model, increased endothelin-1 (ET-1) expression and cardioprotective effects of the dual ET-1 blocker bosentan were demonstrated.	Doxorubicin	12-23	endothelin 1	Mus musculus	70-74
25660617-2	2015	In a murine doxorubicin cardiotoxicity model, increased endothelin-1 (ET-1) expression and cardioprotective effects of the dual ET-1 blocker bosentan were demonstrated.	Bosentan	141-149	endothelin 1	Mus musculus	128-132
25660617-9	2015	In summary, our results demonstrate strong cardioprotective effects of blocking ET-1 receptors against the doxorubicin-related cardiomyopathy and provide evidence to potential underlying signaling pathways.	Doxorubicin	107-118	endothelin 1	Mus musculus	80-84
25056869-9	2015	Likewise, NaHS also restored level of eNOS, CD31, VE-cadherin and ET-1 and maintains endothelial function in Hcy treated cells.	sodium bisulfide	10-14	endothelin 1	Mus musculus	66-70
25399435-9	2015	Loss of ET-1 decreased PASMC proliferation and migration and increased apoptosis under normoxic and hypoxic conditions.	pasmc	23-28	endothelin 1	Mus musculus	8-12
25399435-1	2015	Endothelin-1 (ET-1) increases pulmonary vascular tone through direct effects on pulmonary artery smooth muscle cells (PASMC) via membrane-bound ET-1 receptors.	pasmc	118-123	endothelin 1	Mus musculus	0-12
25399435-1	2015	Endothelin-1 (ET-1) increases pulmonary vascular tone through direct effects on pulmonary artery smooth muscle cells (PASMC) via membrane-bound ET-1 receptors.	pasmc	118-123	endothelin 1	Mus musculus	14-18
25399435-1	2015	Endothelin-1 (ET-1) increases pulmonary vascular tone through direct effects on pulmonary artery smooth muscle cells (PASMC) via membrane-bound ET-1 receptors.	pasmc	118-123	endothelin 1	Mus musculus	144-148
24607776-2	2014	Endothelin-1 (ET-1) and angiotensin II (Ang II) are important modifiers of vascular disease, partly through increased activity of NADPH oxidase and vasoconstrictor prostanoids.	Prostaglandins	164-175	endothelin 1	Mus musculus	14-18
25230003-5	2015	We hypothesize that the administration of BQ-123 post LPS exposure will dismantle a positive feedback loop observed with pro-inflammatory cytokines upstream of ET-1.	cyclo(Trp-Asp-Pro-Val-Leu)	42-48	endothelin 1	Mus musculus	160-164
26509263-9	2015	The metabolomics results suggest that ET-1 overexpression on top of eNOS knockout is associated with a functional recovery of mitochondria (rescue effect in beta-oxidation of fatty acids) and an increase in antioxidative properties (normalization of monounsaturated fatty acids levels).	Fatty Acids	175-186	endothelin 1	Mus musculus	38-42
26509263-9	2015	The metabolomics results suggest that ET-1 overexpression on top of eNOS knockout is associated with a functional recovery of mitochondria (rescue effect in beta-oxidation of fatty acids) and an increase in antioxidative properties (normalization of monounsaturated fatty acids levels).	Fatty Acids, Monounsaturated	250-277	endothelin 1	Mus musculus	38-42
25389292-10	2014	Additionally, we show that fenofibrate, a PPARalpha agonist, increased the expression of miR-199a2 and DNM3os; the former was responsible for reduced expression of HIF-1alpha and ET-1.	Fenofibrate	27-38	endothelin 1	Mus musculus	179-183
25389292-11	2014	In vivo studies of fenofibrate-fed Berkeley sickle mice resulted in increased levels of miR-199a2 and reduced levels of ET-1 in lung tissues.	Fenofibrate	19-30	endothelin 1	Mus musculus	120-124
25389292-12	2014	Our studies provide a potential therapeutic approach whereby fenofibrate-induced miR-199a2 expression can ameliorate PH by reduction of ET-1 levels.	Fenofibrate	61-72	endothelin 1	Mus musculus	136-140
25391901-4	2015	Given that ET-1 stimulates NO production in the CD, we hypothesized that shear stress-induced NO production is downstream of shear stress-induced ENaC activation and ET-1 production in a negative feedback loop.	Cadmium	48-50	endothelin 1	Mus musculus	11-15
25391901-4	2015	Given that ET-1 stimulates NO production in the CD, we hypothesized that shear stress-induced NO production is downstream of shear stress-induced ENaC activation and ET-1 production in a negative feedback loop.	Cadmium	48-50	endothelin 1	Mus musculus	166-170
24607776-2	2014	Endothelin-1 (ET-1) and angiotensin II (Ang II) are important modifiers of vascular disease, partly through increased activity of NADPH oxidase and vasoconstrictor prostanoids.	Prostaglandins	164-175	endothelin 1	Mus musculus	0-12
24607776-3	2014	Since the renin-angiotensin and endothelin systems become activated with age, we hypothesized that aging affects NADPH oxidase- and prostanoid-dependent contractions to ET-1 and Ang II.	Prostaglandins	132-142	endothelin 1	Mus musculus	169-184
25016214-4	2014	Microarray studies from lung homogenates of mice exposed to only 3h of hypoxia revealed endothelin-1 (ET-1) and connective tissue growth factor (CTGF) as the most upregulated genes, and the mitogen-activated protein kinase (MAPK) pathway as the most differentially regulated pathway.	Tritium	65-67	endothelin 1	Mus musculus	88-100
25010841-7	2014	Furthermore, the decrease in ET-1 gene expression induced by re-feeding was blocked by pre-treatment with hexamethonium and atropine.	Hexamethonium	106-119	endothelin 1	Mus musculus	29-33
25010841-7	2014	Furthermore, the decrease in ET-1 gene expression induced by re-feeding was blocked by pre-treatment with hexamethonium and atropine.	Atropine	124-132	endothelin 1	Mus musculus	29-33
24759959-8	2014	RESULTS: MGO prevented the insulin-dependent activation of the IRS1/protein kinase Akt/endothelial nitric oxide synthase (eNOS) pathway, thereby blunting nitric oxide (NO) production, while extracellular signal-regulated kinase (ERK1/2) activation and endothelin-1 (ET-1) release were increased by MGO in MAECs.	Pyruvaldehyde	9-12	endothelin 1	Mus musculus	252-264
24915635-4	2014	NEW METHOD: We have modified the ET1 ischemia model to target the anterior forelimb motor cortex (aFMC) and show that this generates a reproducible focal ischemic injury in mice with consistent behavioral deficits.	afmc	98-102	endothelin 1	Mus musculus	33-36
24287977-0	2014	Upregulation of COX-2/PGE2 by ET-1 mediated through Ca2+-dependent signals in mouse brain microvascular endothelial cells.	Dinoprostone	22-26	endothelin 1	Mus musculus	30-34
24287977-2	2014	The deleterious effects of ET-1 on brain endothelial cells may aggravate brain inflammation mediated through the upregulation of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) system.	Dinoprostone	154-170	endothelin 1	Mus musculus	27-31
24287977-2	2014	The deleterious effects of ET-1 on brain endothelial cells may aggravate brain inflammation mediated through the upregulation of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) system.	Dinoprostone	172-176	endothelin 1	Mus musculus	27-31
24287977-8	2014	Finally, upregulation of COX-2 by ET-1 promoted PGE2 biosynthesis and release in these cells.	Dinoprostone	48-52	endothelin 1	Mus musculus	34-38
24287977-10	2014	Understanding the mechanisms of COX-2/PGE2 system upregulated by ET-1 on brain microvascular endothelial cells may provide rational therapeutic interventions for brain injury and inflammatory diseases.	Dinoprostone	38-42	endothelin 1	Mus musculus	65-69
24590287-4	2014	Here, we determined that podocyte-specific activation of TGF-beta signaling in transgenic mice and BALB/c mice with Adriamycin-induced glomerulosclerosis is associated with endothelin-1 (EDN1) release by podocytes, which mediates mitochondrial oxidative stress and dysfunction in adjacent endothelial cells via paracrine EDN1 receptor type A (EDNRA) activation.	Doxorubicin	116-126	endothelin 1	Mus musculus	173-185
24708674-8	2014	RESULTS: In normal fibroblasts, ET-1 activated c-Abl and protein kinase C (PKC)-delta and induced Fli1 phosphorylation at threonine 312, leading to the decreased DNA binding of Fli1, a potent repressor of the COL1A2 gene, and the increase in type I collagen expression.	Threonine	122-131	endothelin 1	Mus musculus	32-36
24291048-8	2014	PGE(2) was more potent than salbutamol in opposing submaximal pre-contraction to all constrictors tested, and only PGE(2) opposed maximal pre-contraction with endothelin-1.	Prostaglandins E	115-118	endothelin 1	Mus musculus	159-171
24722437-5	2014	Stimulation of primary mouse podocytes with endothelin-1 elicited rapid calcium transients mediated by endothelin type A receptors (ETARs) and endothelin type B receptors (ETBRs).	Calcium	72-79	endothelin 1	Mus musculus	44-56
24590287-4	2014	Here, we determined that podocyte-specific activation of TGF-beta signaling in transgenic mice and BALB/c mice with Adriamycin-induced glomerulosclerosis is associated with endothelin-1 (EDN1) release by podocytes, which mediates mitochondrial oxidative stress and dysfunction in adjacent endothelial cells via paracrine EDN1 receptor type A (EDNRA) activation.	Doxorubicin	116-126	endothelin 1	Mus musculus	187-191
24239798-0	2014	Intermittent hypoxia-induced increases in reactive oxygen species activate NFATc3 increasing endothelin-1 vasoconstrictor reactivity.	Reactive Oxygen Species	42-65	endothelin 1	Mus musculus	93-105
24632840-10	2014	This was associated with a shift towards procontractile ETB signaling in sFlt-1-treated mice, possibly explaining the increased ET-1-induced prostaglandin-mediated vasoconstriction.	etb	56-59	endothelin 1	Mus musculus	128-132
24632840-10	2014	This was associated with a shift towards procontractile ETB signaling in sFlt-1-treated mice, possibly explaining the increased ET-1-induced prostaglandin-mediated vasoconstriction.	Prostaglandins	141-154	endothelin 1	Mus musculus	128-132
24632840-13	2014	The cyclooxygenase-thromboxane signaling route downstream of ET-1 might be a possible target to prevent BP elevation during VEGF inhibition.	Thromboxanes	19-30	endothelin 1	Mus musculus	61-65
24730033-7	2014	The amount of lactate release by ET-1 was lower in Na(x)-/- mice than in wild-type mice.	Lactic Acid	14-21	endothelin 1	Mus musculus	33-37
24523936-4	2014	We therefore hypothesized that blocking the pro-apoptotic TNF-alpha pathway using pentoxifylline could prevent the deleterious effect of the lack of ET-1 in a model for heart failure.	Pentoxifylline	82-96	endothelin 1	Mus musculus	149-153
24586188-4	2014	In the current work we provide direct evidence that the enzyme, which complements CathA action towards ET-1 is a retinoid-inducible lysosomal serine carboxypeptidase 1 (Scpep1), a CathA homolog with previously unknown biological function.	Retinoids	113-121	endothelin 1	Mus musculus	103-107
25863042-4	2014	Recently, there has been considerable interest in the protective role of folic acid (FA) against congenital anomalies via increasing the expression of ET-1.	Folic Acid	73-83	endothelin 1	Mus musculus	151-155
24244514-6	2013	Our results demonstrate that exposure to hypoxia (10% O2) for 3-weeks increased levels of miR-27a and ET-1 in the lungs of C57BL/6 mice and reduced PPARgamma levels.	Oxygen	54-56	endothelin 1	Mus musculus	102-106
24129228-6	2013	The mRNA expression of ET-1 was analyzed by RT-PCR and agarose gel.	Sepharose	55-62	endothelin 1	Mus musculus	23-27
23959559-6	2013	ET1 infusion increased mean arterial pressure and attenuated the blood flow increase produced by neural activity (whisker stimulation) or neocortical application of the endothelium-dependent vasodilator acetylcholine but not A23187.	Acetylcholine	203-216	endothelin 1	Mus musculus	0-3
23887640-4	2013	ET-1-induced reactive oxygen species and inflammation may contribute to atherosclerosis progression and AAA development.	Reactive Oxygen Species	13-36	endothelin 1	Mus musculus	0-4
23959559-7	2013	The cerebrovascular effects of ET1 were abrogated by the ET(A) receptor antagonist BQ123 and were not related to vascular oxidative stress.	cyclo(Trp-Asp-Pro-Val-Leu)	83-88	endothelin 1	Mus musculus	31-34
23959559-9	2013	Furthermore, in vitro studies demonstrated that ET1 suppresses endothelial nitric oxide (NO) production, assessed by its metabolite nitrite, an effect associated with Rho-associated protein kinase-dependent changes in the phosphorylation state of endothelial NO synthase.	Nitric Oxide	75-87	endothelin 1	Mus musculus	48-51
23959559-9	2013	Furthermore, in vitro studies demonstrated that ET1 suppresses endothelial nitric oxide (NO) production, assessed by its metabolite nitrite, an effect associated with Rho-associated protein kinase-dependent changes in the phosphorylation state of endothelial NO synthase.	Nitrites	132-139	endothelin 1	Mus musculus	48-51
23864254-9	2013	In conclusion, administration of CS after reperfusion, but not prior to ischemia, attenuates IIRI by downregulating ET-1 and suppressing sustained MC activation.	Cromolyn Sodium	33-35	endothelin 1	Mus musculus	116-120
22290536-10	2013	In fact, cAMP inhibited ET-1-stimulated TNF-alpha and IL-1beta expressions in adipocytes.	Cyclic AMP	9-13	endothelin 1	Mus musculus	24-28
23698114-0	2013	Endothelin-1 inhibits sodium reabsorption by ET(A) and ET(B) receptors in the mouse cortical collecting duct.	Sodium	22-28	endothelin 1	Mus musculus	0-12
23698114-2	2013	Our previous studies demonstrated that the endothelin-1 gene (edn1) is an early response gene to the action of aldosterone.	Aldosterone	111-122	endothelin 1	Mus musculus	43-55
23698114-2	2013	Our previous studies demonstrated that the endothelin-1 gene (edn1) is an early response gene to the action of aldosterone.	Aldosterone	111-122	endothelin 1	Mus musculus	62-66
23698114-3	2013	Because aldosterone and endothelin-1 (ET-1) have opposing actions on Na reabsorption (JNa) in the kidney, we postulated that stimulation of ET-1 by aldosterone acts as a negative feedback mechanism, acting locally within the CD.	Aldosterone	8-19	endothelin 1	Mus musculus	140-144
23698114-3	2013	Because aldosterone and endothelin-1 (ET-1) have opposing actions on Na reabsorption (JNa) in the kidney, we postulated that stimulation of ET-1 by aldosterone acts as a negative feedback mechanism, acting locally within the CD.	Cadmium	225-227	endothelin 1	Mus musculus	24-36
23698114-3	2013	Because aldosterone and endothelin-1 (ET-1) have opposing actions on Na reabsorption (JNa) in the kidney, we postulated that stimulation of ET-1 by aldosterone acts as a negative feedback mechanism, acting locally within the CD.	Cadmium	225-227	endothelin 1	Mus musculus	140-144
23698114-5	2013	In contrast, ET-1 increases Na and water excretion through its binding to receptors in the CD.	Water	35-40	endothelin 1	Mus musculus	13-17
23698114-5	2013	In contrast, ET-1 increases Na and water excretion through its binding to receptors in the CD.	Cadmium	91-93	endothelin 1	Mus musculus	13-17
23698114-6	2013	To date, direct measurement of the quantitative effect of ET-1 on transepithelial JNa in the isolated in vitro microperfused mouse CD has not been determined.	Cadmium	131-133	endothelin 1	Mus musculus	58-62
23940720-7	2013	Correspondingly, NOX1 gene silencing abolished ET-1-induced O2 - production and increased CD38-ADP-ribosylcyclase activity in CAMs, while activation of NOX1 by overexpression of Rac1 or Vav2 or administration of exogenous O2 - significantly increased CD38 internalization in CAMs.	Superoxides	60-62	endothelin 1	Mus musculus	47-51
23940720-7	2013	Correspondingly, NOX1 gene silencing abolished ET-1-induced O2 - production and increased CD38-ADP-ribosylcyclase activity in CAMs, while activation of NOX1 by overexpression of Rac1 or Vav2 or administration of exogenous O2 - significantly increased CD38 internalization in CAMs.	Superoxides	222-224	endothelin 1	Mus musculus	47-51
23940720-7	2013	Correspondingly, NOX1 gene silencing abolished ET-1-induced O2 - production and increased CD38-ADP-ribosylcyclase activity in CAMs, while activation of NOX1 by overexpression of Rac1 or Vav2 or administration of exogenous O2 - significantly increased CD38 internalization in CAMs.	cams	126-130	endothelin 1	Mus musculus	47-51
23895583-5	2013	RESULTS: Linear regression analysis showed that the level of serum UA had a significant positive correlation with serum endothelin-1 and the percentage of collagen I positive area, but a negative correlation with serum nitric oxide (NO) and NO/endothelin-1 ratio.	Uric Acid	67-69	endothelin 1	Mus musculus	120-132
23895583-5	2013	RESULTS: Linear regression analysis showed that the level of serum UA had a significant positive correlation with serum endothelin-1 and the percentage of collagen I positive area, but a negative correlation with serum nitric oxide (NO) and NO/endothelin-1 ratio.	Uric Acid	67-69	endothelin 1	Mus musculus	244-256
23670300-10	2013	ET-1-induced oxidative stress measured by dihydroethidium staining (P&lt;0.05) and NADPH oxidase activity assessed with lucigenin chemiluminescence (P&lt;0.05) were blunted by CSF1 deficiency.	dihydroethidium	42-57	endothelin 1	Mus musculus	0-4
23670300-10	2013	ET-1-induced oxidative stress measured by dihydroethidium staining (P&lt;0.05) and NADPH oxidase activity assessed with lucigenin chemiluminescence (P&lt;0.05) were blunted by CSF1 deficiency.	10,10'-dimethyl-9,9'-biacridinium	120-129	endothelin 1	Mus musculus	0-4
23279852-6	2013	Topical treatment with EDN1 receptor (EDNRB) antagonist BQ788 abrogated UV-induced melanocyte activation and recapitulated the phenotype seen in EDN1(ep-/-)  mice.	BQ 788	56-61	endothelin 1	Mus musculus	23-27
23279852-6	2013	Topical treatment with EDN1 receptor (EDNRB) antagonist BQ788 abrogated UV-induced melanocyte activation and recapitulated the phenotype seen in EDN1(ep-/-)  mice.	BQ 788	56-61	endothelin 1	Mus musculus	145-149
23656416-6	2013	Furthermore, this oxygen effect was curtailed by the ET-1/ETA receptor antagonist BQ-123.	Oxygen	18-24	endothelin 1	Mus musculus	53-57
23656416-6	2013	Furthermore, this oxygen effect was curtailed by the ET-1/ETA receptor antagonist BQ-123.	cyclo(Trp-Asp-Pro-Val-Leu)	82-88	endothelin 1	Mus musculus	53-57
23540699-3	2013	PLCepsilon small interfering RNA (siRNA) in ventricular myocytes decreases endothelin-1 (ET-1)-dependent elevation of nuclear calcium and activation of nuclear protein kinase D (PKD).	Calcium	126-133	endothelin 1	Mus musculus	75-87
22109832-9	2013	Melatonin improved the impairment of endothelial damage and reduced loss of SIRT1 and eNOS decreasing p53 and ET-1 expression.	Melatonin	0-9	endothelin 1	Mus musculus	110-114
23343326-0	2013	Up-regulation of COX-2/PGE2 by endothelin-1 via MAPK-dependent NF-kappaB pathway in mouse brain microvascular endothelial cells.	Dinoprostone	23-27	endothelin 1	Mus musculus	31-43
23343326-2	2013	The deleterious effects of ET-1 on endothelial cells may aggravate brain inflammation mediated through the regulation of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) system in various cell types.	Dinoprostone	146-162	endothelin 1	Mus musculus	27-31
23343326-2	2013	The deleterious effects of ET-1 on endothelial cells may aggravate brain inflammation mediated through the regulation of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) system in various cell types.	Dinoprostone	164-168	endothelin 1	Mus musculus	27-31
23343326-8	2013	Finally, up-regulation of COX-2 by ET-1 promoted PGE2 release in these cells.	Dinoprostone	49-53	endothelin 1	Mus musculus	35-39
23343326-9	2013	CONCLUSIONS: These results suggested that in mouse bEnd.3 cells, activation of NF-kappaB by ETB-dependent MAPK cascades is essential for ET-1-induced up-regulation of COX-2/PGE2 system.	Dinoprostone	173-177	endothelin 1	Mus musculus	137-141
23343326-10	2013	Understanding the mechanisms of COX-2 expression and PGE2 release regulated by ET-1/ETB system on brain microvascular endothelial cells may provide rationally therapeutic interventions for brain injury or inflammatory diseases.	Dinoprostone	53-57	endothelin 1	Mus musculus	79-83
23590158-9	2013	Finally, the hypoxia-induced pulmonary overexpression of endothelin-1 mRNA was markedly reduced by creatine + D-ribose.	Creatine	99-107	endothelin 1	Mus musculus	57-69
23160444-8	2013	SUMMARY: In the collecting duct, the ET1/nitric oxide pathways are intimately linked, and deletion of collecting duct ET1, ETB receptor or NOS1beta results in a salt-sensitive phenotype, which is at least partially dependent on dysregulation of sodium and water reabsorption.	Nitric Oxide	41-53	endothelin 1	Mus musculus	37-40
23160444-8	2013	SUMMARY: In the collecting duct, the ET1/nitric oxide pathways are intimately linked, and deletion of collecting duct ET1, ETB receptor or NOS1beta results in a salt-sensitive phenotype, which is at least partially dependent on dysregulation of sodium and water reabsorption.	Salts	161-165	endothelin 1	Mus musculus	118-121
23160444-8	2013	SUMMARY: In the collecting duct, the ET1/nitric oxide pathways are intimately linked, and deletion of collecting duct ET1, ETB receptor or NOS1beta results in a salt-sensitive phenotype, which is at least partially dependent on dysregulation of sodium and water reabsorption.	Sodium	245-251	endothelin 1	Mus musculus	118-121
23160444-8	2013	SUMMARY: In the collecting duct, the ET1/nitric oxide pathways are intimately linked, and deletion of collecting duct ET1, ETB receptor or NOS1beta results in a salt-sensitive phenotype, which is at least partially dependent on dysregulation of sodium and water reabsorption.	Water	256-261	endothelin 1	Mus musculus	118-121
23108654-7	2012	These data suggest that, in DOCA-salt hypertension in mice, cytochrome P450 1B1 plays a pivotal role in cardiovascular dysfunction, renal damage, and inflammation, and increased levels of catecholamines, vasopressin, and endothelin-1, consequent to generation of reactive oxygen species and activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, and cellular-Src independent of eicosanoids.	Desoxycorticosterone Acetate	28-32	endothelin 1	Mus musculus	221-233
24335996-3	2013	We show that GRAF3-deficient mice exhibit significant hypertension and increased pressor responses to angiotensin II and endothelin-1; these effects are prevented by treatment with the Rho-kinase inhibitor, Y27632.	Y 27632	207-213	endothelin 1	Mus musculus	121-133
23108654-7	2012	These data suggest that, in DOCA-salt hypertension in mice, cytochrome P450 1B1 plays a pivotal role in cardiovascular dysfunction, renal damage, and inflammation, and increased levels of catecholamines, vasopressin, and endothelin-1, consequent to generation of reactive oxygen species and activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, and cellular-Src independent of eicosanoids.	Salts	33-37	endothelin 1	Mus musculus	221-233
23108654-3	2012	DOCA-salt increased systolic blood pressure, cardiac and renal cytochrome P450 1B1 activity, and plasma levels of catecholamines, vasopressin, and endothelin-1 in wild-type (Cyp1b1(+/+)) mice that were minimized in Cyp1b1(-/-) mice.	doca-salt	0-9	endothelin 1	Mus musculus	147-159
23018104-4	2012	In the present study, we showed that pretreatment with GW3965, a specific ligand of LXR, significantly attenuated lipopolysaccharide (LPS)-induced ET-1 in mice plasma.	GW 3965	55-61	endothelin 1	Mus musculus	147-151
22483687-6	2012	While scratching and wipe responses to ET-1 (30 pmol) were potentiated by BQ-788 (an ET(B) receptor antagonist) and reduced by co-injection of BQ-788 plus BQ-123 (an ET(A) receptor antagonist), BQ-123 alone inhibited scratching responses only.	BQ 788	74-80	endothelin 1	Mus musculus	39-43
22326502-10	2012	SIGNIFICANCE: These results demonstrate that endogenous GPER inhibits ET-1-induced vasoconstriction, an effect that may be associated with reduced VSMC Ca(2+) sensitivity.	vsmc	147-151	endothelin 1	Mus musculus	70-74
22483687-6	2012	While scratching and wipe responses to ET-1 (30 pmol) were potentiated by BQ-788 (an ET(B) receptor antagonist) and reduced by co-injection of BQ-788 plus BQ-123 (an ET(A) receptor antagonist), BQ-123 alone inhibited scratching responses only.	BQ 788	143-149	endothelin 1	Mus musculus	39-43
22326502-1	2012	AIMS: An increase in intracellular vascular smooth muscle cell calcium concentration (VSMC [Ca(2+)](i)) is essential for endothelin-1 (ET-1)-induced vasoconstriction.	Calcium	63-70	endothelin 1	Mus musculus	121-133
22483687-6	2012	While scratching and wipe responses to ET-1 (30 pmol) were potentiated by BQ-788 (an ET(B) receptor antagonist) and reduced by co-injection of BQ-788 plus BQ-123 (an ET(A) receptor antagonist), BQ-123 alone inhibited scratching responses only.	cyclo(Trp-Asp-Pro-Val-Leu)	155-161	endothelin 1	Mus musculus	39-43
22326502-1	2012	AIMS: An increase in intracellular vascular smooth muscle cell calcium concentration (VSMC [Ca(2+)](i)) is essential for endothelin-1 (ET-1)-induced vasoconstriction.	Calcium	63-70	endothelin 1	Mus musculus	135-139
22483687-6	2012	While scratching and wipe responses to ET-1 (30 pmol) were potentiated by BQ-788 (an ET(B) receptor antagonist) and reduced by co-injection of BQ-788 plus BQ-123 (an ET(A) receptor antagonist), BQ-123 alone inhibited scratching responses only.	cyclo(Trp-Asp-Pro-Val-Leu)	194-200	endothelin 1	Mus musculus	39-43
22326502-1	2012	AIMS: An increase in intracellular vascular smooth muscle cell calcium concentration (VSMC [Ca(2+)](i)) is essential for endothelin-1 (ET-1)-induced vasoconstriction.	vsmc	86-90	endothelin 1	Mus musculus	121-133
22326502-1	2012	AIMS: An increase in intracellular vascular smooth muscle cell calcium concentration (VSMC [Ca(2+)](i)) is essential for endothelin-1 (ET-1)-induced vasoconstriction.	vsmc	86-90	endothelin 1	Mus musculus	135-139
22820168-0	2012	Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection.	Formaldehyde	119-127	endothelin 1	Mus musculus	19-31
22326502-8	2012	Despite the more potent vasoconstriction to ET-1, GPER deficiency was associated with a marked reduction in the ET-1-stimulated VSMC [Ca(2+)](i) increase, suggesting an increase in myofilament force sensitivity to [Ca(2+)](i).	vsmc	128-132	endothelin 1	Mus musculus	112-116
22525377-0	2012	Renal, retinal and cardiac changes in type 2 diabetes are attenuated by macitentan, a dual endothelin receptor antagonist.	macitentan	72-82	endothelin 1	Mus musculus	91-101
22820168-4	2012	MAIN METHODS: The current study assesses the effects of ET-1 over-expression specifically targeted to astrocytes (GET-1) or endothelial cells (TET-1) on the expression of pain-like behaviors induced by a model of inflammatory pain, consisting of a formalin injection into the hind paw.	Formaldehyde	248-256	endothelin 1	Mus musculus	56-60
23181126-5	2012	Pretreatment with systemically administered naloxone significantly reduced the number of scratches, while co-injection of naloxone substantially augmented the effect of ET-1.	Naloxone	122-130	endothelin 1	Mus musculus	169-173
23293787-4	2012	Finally, increasing doses of the MEK inhibitors, PD98,059 or U0126,were incubated with mIMCD-3 cells and the ET-1 dependent nitrite production determined.	U 0126	61-66	endothelin 1	Mus musculus	109-113
23293787-4	2012	Finally, increasing doses of the MEK inhibitors, PD98,059 or U0126,were incubated with mIMCD-3 cells and the ET-1 dependent nitrite production determined.	Nitrites	124-131	endothelin 1	Mus musculus	109-113
23293787-6	2012	ET-1 also stimulates nitrite production by mIMCD-3 cells (basal: 54.5+-26 pmol/mg pr/hvs ET-1: 221+-28 pmol/mg pr/h; N=4) via the ETB receptor (BQ788+ET-1: 83.7+-27 pmol/mg pr/h);however, ET-1 does not regulate NOS1 or NOS3 expression.	Nitrites	21-28	endothelin 1	Mus musculus	0-4
23293787-8	2012	SIGNIFICANCE: Although the mouse IMCD-3 cells only express the NOS1beta splice variant, ET-1 did regulate mouse IMCD nitrite production.	Nitrites	117-124	endothelin 1	Mus musculus	88-92
23181126-6	2012	Co-injection of nor-Binaltorphimine (nor-BNI), a KOR antagonist, significantly increased the number of scratches induced by ET-1.	norbinaltorphimine	16-35	endothelin 1	Mus musculus	124-128
23181126-6	2012	Co-injection of nor-Binaltorphimine (nor-BNI), a KOR antagonist, significantly increased the number of scratches induced by ET-1.	norbinaltorphimine	37-44	endothelin 1	Mus musculus	124-128
23293787-1	2012	AIMS: To determine if endothelin-1 (ET-1) stimulates the phosphorylation of ERK1/2 in the mouse inner medullary collecting duct (IMCD), and if this in turn upregulates nitric oxide (NO) production.	Nitric Oxide	168-180	endothelin 1	Mus musculus	22-34
23293787-1	2012	AIMS: To determine if endothelin-1 (ET-1) stimulates the phosphorylation of ERK1/2 in the mouse inner medullary collecting duct (IMCD), and if this in turn upregulates nitric oxide (NO) production.	Nitric Oxide	168-180	endothelin 1	Mus musculus	36-40
22257795-5	2012	ET-1-induced rise in [Ca]i involves the newly described stromal-interaction molecule-1/orai1 pathway to increase store-operated calcium entry.	Calcium	128-135	endothelin 1	Mus musculus	0-4
22775220-9	2012	KEY FINDINGS: beta-CPX (10 mg/kg) significantly suppressed skin pigmentation and mRNA expression of cyclooxygenase-2, ET-1 receptors, low-affinity neurotrophin receptor, PGE(2) receptor (EP1), melanocortin 1 receptor (MC1R), tyrosinase (Tyr), tyrosinase-related protein (Tyrp) 1 and microphthalmia transcription factor.	Beta-Cryptoxanthin	14-22	endothelin 1	Mus musculus	118-122
22775220-10	2012	beta-CPX (10 microg/ml) suppressed melanogenesis induced by PGE(2), MSH and ET-1.	Beta-Cryptoxanthin	0-8	endothelin 1	Mus musculus	76-80
22747786-4	2012	OBJECTIVE: The goal of this study was to examine whether ET-1-induced COX-2 expression and prostaglandin E2 (PGE2) release were mediated through a c-Src-dependent transactivation of epidermal growth factor receptor (EGFR) pathway in brain microvascular endothelial cells (bEnd.3 cells).	Dinoprostone	91-107	endothelin 1	Mus musculus	57-61
22747786-4	2012	OBJECTIVE: The goal of this study was to examine whether ET-1-induced COX-2 expression and prostaglandin E2 (PGE2) release were mediated through a c-Src-dependent transactivation of epidermal growth factor receptor (EGFR) pathway in brain microvascular endothelial cells (bEnd.3 cells).	Dinoprostone	109-113	endothelin 1	Mus musculus	57-61
22747786-11	2012	Ultimately, upregulation of COX-2 by ET-1 promoted PGE2 biosynthesis and release in bEnd.3 cells.	Dinoprostone	51-55	endothelin 1	Mus musculus	37-41
22747786-13	2012	Understanding the mechanisms of COX-2 expression and PGE2 release regulated by ET-1/ETB system on brain microvascular endothelial cells may provide rational therapeutic interventions for brain injury and inflammatory diseases.	Dinoprostone	53-57	endothelin 1	Mus musculus	79-83
22689747-8	2012	CIH markedly increased endothelin 1 in cerebral blood vessels, whereas cerebrovascular dysfunction and oxidative stress were abrogated by neocortical application of the endothelin type A receptor antagonist BQ123.	cih	0-3	endothelin 1	Mus musculus	23-35
22689747-9	2012	These data demonstrate for the first time that CIH alters key regulatory mechanisms of the cerebral circulation through endothelin 1 and NADPH oxidase-derived radicals.	cih	47-50	endothelin 1	Mus musculus	120-132
22209709-1	2012	Aldosterone stimulates the endothelin-1 gene (Edn1) in renal collecting duct (CD) cells by a mechanism involving the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR).	Aldosterone	0-11	endothelin 1	Mus musculus	46-50
22209709-2	2012	The goal of the present study was to determine if the synthetic glucocorticoid dexamethasone affected Edn1 gene expression and to characterize GR binding patterns to an element in the Edn1 promoter.	Dexamethasone	79-92	endothelin 1	Mus musculus	102-106
22209709-3	2012	Dexamethasone (1muM) induced a 4-fold increase in Edn1 mRNA in mIMCD-3 inner medullary CD cells.	Dexamethasone	0-13	endothelin 1	Mus musculus	50-54
22209709-3	2012	Dexamethasone (1muM) induced a 4-fold increase in Edn1 mRNA in mIMCD-3 inner medullary CD cells.	Cadmium	66-68	endothelin 1	Mus musculus	50-54
22209709-5	2012	RU486 inhibition of GR completely blocked dexamethasone action on Edn1.	Dexamethasone	42-55	endothelin 1	Mus musculus	66-70
22209709-9	2012	The results indicate that dexamethasone acts on Edn1 exclusively through GR and not MR.	Dexamethasone	26-39	endothelin 1	Mus musculus	48-52
22209709-10	2012	DNA affinity purification studies revealed that either dexamethasone or aldosterone resulted in GR binding to the same hormone response element in the Edn1Edn1 promoter.	Dexamethasone	55-68	endothelin 1	Mus musculus	151-159
22209709-10	2012	DNA affinity purification studies revealed that either dexamethasone or aldosterone resulted in GR binding to the same hormone response element in the Edn1Edn1 promoter.	Aldosterone	72-83	endothelin 1	Mus musculus	151-159
22473360-5	2012	A lower concentration of tungstate (0.1 mM) induced voltage-dependent activation of the vascular BKalphabeta(1) channel without reducing current amplitude, and consistently exerted a vasodilatory action on wild-type but not on beta(1)-knockout mouse arteries pre-contracted with endothelin-1.	tungstate	25-34	endothelin 1	Mus musculus	279-291
22357920-1	2012	Collecting duct (CD) endothelin-1 (ET-1) is an important autocrine inhibitor of Na and water transport.	Water	87-92	endothelin 1	Mus musculus	21-33
22357920-1	2012	Collecting duct (CD) endothelin-1 (ET-1) is an important autocrine inhibitor of Na and water transport.	Water	87-92	endothelin 1	Mus musculus	35-39
22357920-2	2012	CD ET-1 production is stimulated by extracellular fluid volume expansion and tubule fluid flow, suggesting a mechanism coupling CD Na delivery and ET-1 synthesis.	cd na	128-133	endothelin 1	Mus musculus	3-7
22357920-4	2012	Flow with 300 mosmol/l NaCl increased ET-1 mRNA to 65% above that observed under static conditions.	Sodium Chloride	23-27	endothelin 1	Mus musculus	38-42
22357920-5	2012	Increasing perfusate osmolarity to 450 mosmol/l with NaCl or Na acetate increased ET-1 mRNA to ~184% compared with no flow, which was not observed when osmolarity was increased using mannitol or urea.	Sodium Chloride	53-57	endothelin 1	Mus musculus	82-86
22357920-5	2012	Increasing perfusate osmolarity to 450 mosmol/l with NaCl or Na acetate increased ET-1 mRNA to ~184% compared with no flow, which was not observed when osmolarity was increased using mannitol or urea.	na acetate	61-71	endothelin 1	Mus musculus	82-86
22357920-5	2012	Increasing perfusate osmolarity to 450 mosmol/l with NaCl or Na acetate increased ET-1 mRNA to ~184% compared with no flow, which was not observed when osmolarity was increased using mannitol or urea.	Urea	195-199	endothelin 1	Mus musculus	82-86
22357920-7	2012	Inhibition of epithelial Na channel (ENaC) with amiloride or benzamil abolished the flow response, suggesting involvement of ENaC in flow-regulated ET-1 synthesis.	Amiloride	48-57	endothelin 1	Mus musculus	148-152
22357920-7	2012	Inhibition of epithelial Na channel (ENaC) with amiloride or benzamil abolished the flow response, suggesting involvement of ENaC in flow-regulated ET-1 synthesis.	benzamil	61-69	endothelin 1	Mus musculus	148-152
22442497-9	2012	The TRPV1 agonist SA13353 attenuated whereas TRPV1 antagonist capsazepine mimicked cold stress- or ET-1-induced cardiac anomalies.	capsazepine	62-73	endothelin 1	Mus musculus	99-103
22209709-0	2012	Dexamethasone stimulates endothelin-1 gene expression in renal collecting duct cells.	Dexamethasone	0-13	endothelin 1	Mus musculus	25-37
22209709-1	2012	Aldosterone stimulates the endothelin-1 gene (Edn1) in renal collecting duct (CD) cells by a mechanism involving the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR).	Aldosterone	0-11	endothelin 1	Mus musculus	27-39
22257795-6	2012	Sensitization of contractile proteins to calcium during ET-1-induced contraction of vascular smooth muscle cells includes activation of p63Rho guanine nucleotide exchange factor and increase in O-GlcNAcylation, a form of posttranslational modification.	Calcium	41-48	endothelin 1	Mus musculus	56-60
22490719-0	2012	[Effect of liver X receptor agonist T0901317 on endothelin-1 induced murine HL-1 cardiomyocytes hypertrophy].	T0901317	36-44	endothelin 1	Mus musculus	48-60
22320712-7	2012	Treatment with the non-selective ET(A)/ET(B) receptor antagonist bosentan, and selective ET(A) or ET(B) receptor antagonists BQ-123 or BQ-788, respectively, inhibited ET-1- and ovalbumin-induced neutrophil migration to the peritoneal cavity.	Bosentan	65-73	endothelin 1	Mus musculus	167-172
22320712-7	2012	Treatment with the non-selective ET(A)/ET(B) receptor antagonist bosentan, and selective ET(A) or ET(B) receptor antagonists BQ-123 or BQ-788, respectively, inhibited ET-1- and ovalbumin-induced neutrophil migration to the peritoneal cavity.	cyclo(Trp-Asp-Pro-Val-Leu)	125-131	endothelin 1	Mus musculus	167-172
22320712-7	2012	Treatment with the non-selective ET(A)/ET(B) receptor antagonist bosentan, and selective ET(A) or ET(B) receptor antagonists BQ-123 or BQ-788, respectively, inhibited ET-1- and ovalbumin-induced neutrophil migration to the peritoneal cavity.	BQ 788	135-141	endothelin 1	Mus musculus	167-172
22320712-9	2012	The ET-1- and ovalbumin-induced neutrophil recruitment were reduced in TNFR1 deficient mice, and by treatments targeting CXCL1 or CXC chemokine receptor 2 (CXCR2); further, treatment with bosentan, BQ-123, or BQ-788 inhibited ET-1- and antigen-induced production of TNFalpha and CXCL1.	Bosentan	188-196	endothelin 1	Mus musculus	4-8
22320712-9	2012	The ET-1- and ovalbumin-induced neutrophil recruitment were reduced in TNFR1 deficient mice, and by treatments targeting CXCL1 or CXC chemokine receptor 2 (CXCR2); further, treatment with bosentan, BQ-123, or BQ-788 inhibited ET-1- and antigen-induced production of TNFalpha and CXCL1.	Bosentan	188-196	endothelin 1	Mus musculus	226-230
22320712-9	2012	The ET-1- and ovalbumin-induced neutrophil recruitment were reduced in TNFR1 deficient mice, and by treatments targeting CXCL1 or CXC chemokine receptor 2 (CXCR2); further, treatment with bosentan, BQ-123, or BQ-788 inhibited ET-1- and antigen-induced production of TNFalpha and CXCL1.	cyclo(Trp-Asp-Pro-Val-Leu)	198-204	endothelin 1	Mus musculus	4-8
22320712-9	2012	The ET-1- and ovalbumin-induced neutrophil recruitment were reduced in TNFR1 deficient mice, and by treatments targeting CXCL1 or CXC chemokine receptor 2 (CXCR2); further, treatment with bosentan, BQ-123, or BQ-788 inhibited ET-1- and antigen-induced production of TNFalpha and CXCL1.	BQ 788	209-215	endothelin 1	Mus musculus	4-8
23029469-9	2012	Our results indicate that ET-1 can modulate pH homeostasis in PASMCs via a signaling pathway that includes Rho kinase and that, in contrast to systemic vascular smooth muscle, activation of PKC does not appear to be an important regulator of PASMC pH(i).	pasmc	62-67	endothelin 1	Mus musculus	26-30
23163110-5	2012	METHODS: We developed a protocol for non-radioactive in situ hybridization for the mRNA of the two endothelin receptors on paraffin-embedded tissue using digoxigenin-labeled RNA probes.	Paraffin	123-131	endothelin 1	Mus musculus	99-109
23163110-5	2012	METHODS: We developed a protocol for non-radioactive in situ hybridization for the mRNA of the two endothelin receptors on paraffin-embedded tissue using digoxigenin-labeled RNA probes.	Digoxigenin	154-165	endothelin 1	Mus musculus	99-109
21918182-2	2012	Compromise of ET-1 signaling or ETB receptors in the CD cause sodium retention and increase blood pressure.	Cadmium	53-55	endothelin 1	Mus musculus	14-18
21918182-2	2012	Compromise of ET-1 signaling or ETB receptors in the CD cause sodium retention and increase blood pressure.	Sodium	62-68	endothelin 1	Mus musculus	14-18
21918182-6	2012	ET-1 significantly decreased ENaC open probability in CD isolated from wild-type (WT) and CD ETA KO mice but not CD ETB KO and CD ETA/B KO mice.	Cadmium	54-56	endothelin 1	Mus musculus	0-4
21918182-6	2012	ET-1 significantly decreased ENaC open probability in CD isolated from wild-type (WT) and CD ETA KO mice but not CD ETB KO and CD ETA/B KO mice.	Cadmium	90-92	endothelin 1	Mus musculus	0-4
21918182-6	2012	ET-1 significantly decreased ENaC open probability in CD isolated from wild-type (WT) and CD ETA KO mice but not CD ETB KO and CD ETA/B KO mice.	Cadmium	90-92	endothelin 1	Mus musculus	0-4
23029469-7	2012	We found that application of exogenous ET-1 increased pH(i) and NHE activity in PASMCs and that the ET-1-induced augmentation of NHE was prevented in PASMCs pretreated with an inhibitor of Rho kinase, but not inhibitors of PKC.	pasmcs	80-86	endothelin 1	Mus musculus	39-43
23029469-7	2012	We found that application of exogenous ET-1 increased pH(i) and NHE activity in PASMCs and that the ET-1-induced augmentation of NHE was prevented in PASMCs pretreated with an inhibitor of Rho kinase, but not inhibitors of PKC.	pasmcs	150-156	endothelin 1	Mus musculus	39-43
23029469-7	2012	We found that application of exogenous ET-1 increased pH(i) and NHE activity in PASMCs and that the ET-1-induced augmentation of NHE was prevented in PASMCs pretreated with an inhibitor of Rho kinase, but not inhibitors of PKC.	pasmcs	150-156	endothelin 1	Mus musculus	100-104
23029469-9	2012	Our results indicate that ET-1 can modulate pH homeostasis in PASMCs via a signaling pathway that includes Rho kinase and that, in contrast to systemic vascular smooth muscle, activation of PKC does not appear to be an important regulator of PASMC pH(i).	pasmcs	62-68	endothelin 1	Mus musculus	26-30
21926265-8	2011	Treatment with RSG attenuated hypoxia-induced activation of HIF-1alpha, NF-kappaB activation, and ET-1 signaling pathway components.	Rosiglitazone	15-18	endothelin 1	Mus musculus	98-102
21926265-9	2011	Similarly, treatment with chetomin or CAPE prevented hypoxia-induced increases in HPAEC ET-1 mRNA and protein levels.	chetomin	26-34	endothelin 1	Mus musculus	88-92
21852551-11	2011	In intact SAN preparations, IP(3)R agonists, endothelin-1 and IP(3)-butyryloxymethyl ester both increased intracellular Ca(2+) and the pacemaker firing rate, whereas the IP(3)R antagonist, 2-aminoethoxydiphenyl borate decreased Ca(2+) and the firing rate.	2-aminoethoxydiphenyl borate	189-217	endothelin 1	Mus musculus	45-57
21885830-5	2011	METHODS AND RESULTS: We find that p63RhoGEF is present across SM tissues and demonstrate that silencing of the endogenous p63RhoGEF in mouse portal vein inhibits contractile force induced by endothelin-1 to a greater extent than the predominantly Galpha(12/13)-mediated thromboxane analog U46619.	galpha	247-253	endothelin 1	Mus musculus	191-203
21885830-5	2011	METHODS AND RESULTS: We find that p63RhoGEF is present across SM tissues and demonstrate that silencing of the endogenous p63RhoGEF in mouse portal vein inhibits contractile force induced by endothelin-1 to a greater extent than the predominantly Galpha(12/13)-mediated thromboxane analog U46619.	Thromboxanes	270-281	endothelin 1	Mus musculus	191-203
21885830-8	2011	This reinforces the results based on endothelin-1, because phenylephrine is thought to act exclusively through Galpha(q/11).	Phenylephrine	59-72	endothelin 1	Mus musculus	37-49
20815727-6	2011	ET-1 and dHAND protein levels were significantly increased in vitamin B12-supplemented embryos compared to the RA-exposed group in embryonic branchial region.	Vitamin B 12	62-73	endothelin 1	Mus musculus	0-4
21622531-4	2011	CN(+) similarly promoted podocyte apoptosis, and apoptosis induced by either angiotensin II or endothelin-1 was blocked by FK506.	Tacrolimus	123-128	endothelin 1	Mus musculus	95-107
20815727-6	2011	ET-1 and dHAND protein levels were significantly increased in vitamin B12-supplemented embryos compared to the RA-exposed group in embryonic branchial region.	Tretinoin	111-113	endothelin 1	Mus musculus	0-4
20815727-7	2011	CONCLUSIONS: These results suggest that vitamin B12 may prevent RA-induced craniofacial abnormalities via prevention of an RA-induced decrease of ET-1 and dHAND protein levels in the branchial region during the organogenic period.	Vitamin B 12	40-51	endothelin 1	Mus musculus	146-150
20815727-7	2011	CONCLUSIONS: These results suggest that vitamin B12 may prevent RA-induced craniofacial abnormalities via prevention of an RA-induced decrease of ET-1 and dHAND protein levels in the branchial region during the organogenic period.	Tretinoin	123-125	endothelin 1	Mus musculus	146-150
20942830-12	2011	The pEC(50) for endothelin-1 was about 6.9-fold higher in the HFD compared with SD group.	SD 0006	80-82	endothelin 1	Mus musculus	16-28
21482739-6	2011	The ET-A receptor-specific antagonist BQ123 significantly attenuated autoantibody-induced hypertension, proteinuria, and renal damage in pregnant mice, demonstrating that autoantibody-induced ET-1 production contributes to pathophysiology.	cyclo(Trp-Asp-Pro-Val-Leu)	38-43	endothelin 1	Mus musculus	192-196
21536328-8	2011	Only half of the microglial cells that responded to ATP also responded to endothelin-1, serotonin and histamine.	Adenosine Triphosphate	52-55	endothelin 1	Mus musculus	74-86
21547665-6	2011	In the experiment to assess prevention of endothelin-1-induced sudden death in mice, compound 5b showed comparable activity to bosentan, and 30 was more potent than bosentan.	Bosentan	165-173	endothelin 1	Mus musculus	42-54
21451422-1	2011	BACKGROUND: The cardiac nitric oxide and endothelin-1 (ET-1) systems are closely linked and play a critical role in cardiac physiology.	Nitric Oxide	24-36	endothelin 1	Mus musculus	55-59
21156825-7	2011	Telmisartan inhibited 9,11-dideoxy-11alpha,9alpha-epoxymethanoprostaglandin F(2alpha) (U46619)- or endothelin-1-induced contractions.	Telmisartan	0-11	endothelin 1	Mus musculus	99-111
21687504-5	2011	When analyzing S1P-induced vasoconstriction in mouse basilar artery, we observed that JTE-013 inhibited not only the effect of S1P, but also the effect of U46619, endothelin-1 or high KCl; JTE-013 strongly inhibited responses to S1P in S1P(2) receptor knockout mice.	JTE 013	86-93	endothelin 1	Mus musculus	163-175
21068089-7	2011	Poly(I:C)-induced EDN1, ECE1 and MX2 was not blocked in mice with the type I IFN receptor deleted.	Poly I-C	0-9	endothelin 1	Mus musculus	18-22
21068089-8	2011	However, poly(I:C)-induced EDN1 and ECE1, but not poly(I:C)-induced ICAM-1 expression was blocked in mice with the TLR3 signalling protein TRIF/TICAM-1 deleted.	Poly I-C	9-17	endothelin 1	Mus musculus	27-31
21068089-8	2011	However, poly(I:C)-induced EDN1 and ECE1, but not poly(I:C)-induced ICAM-1 expression was blocked in mice with the TLR3 signalling protein TRIF/TICAM-1 deleted.	Poly I-C	9-18	endothelin 1	Mus musculus	27-31
20813769-5	2011	RESULTS: ET-1 constricted AA stronger than EA in ETB(-/-) and ETB(+/+) mice.	etb	49-52	endothelin 1	Mus musculus	9-13
20813769-5	2011	RESULTS: ET-1 constricted AA stronger than EA in ETB(-/-) and ETB(+/+) mice.	etb	62-65	endothelin 1	Mus musculus	9-13
20813769-6	2011	Results in AA: ET-1 induced similar constrictions in ETB(-/-) and ETB(+/+) mice.	etb	53-56	endothelin 1	Mus musculus	15-19
20813769-6	2011	Results in AA: ET-1 induced similar constrictions in ETB(-/-) and ETB(+/+) mice.	etb	66-69	endothelin 1	Mus musculus	15-19
20813769-10	2011	Results in EA: ET-1 constricted EA stronger in ETB(+/+) compared to ETB(-/-).	etb	47-50	endothelin 1	Mus musculus	15-19
20813769-13	2011	L-NAME decreased basal diameter in ETB(+/+), but not in ETB(-/-) mice and increased the ET-1 response similarly in both groups.	NG-Nitroarginine Methyl Ester	0-6	endothelin 1	Mus musculus	88-92
21062919-1	2011	AIMS: Binary transgenic (BT) mice with doxycycline (DOX)-suppressible cardiac-specific overexpression of endothelin-1 (ET-1) exhibit progressive heart failure (HF), QRS prolongation, and death following DOX withdrawal.	Doxycycline	39-50	endothelin 1	Mus musculus	105-117
21062919-1	2011	AIMS: Binary transgenic (BT) mice with doxycycline (DOX)-suppressible cardiac-specific overexpression of endothelin-1 (ET-1) exhibit progressive heart failure (HF), QRS prolongation, and death following DOX withdrawal.	Doxycycline	39-50	endothelin 1	Mus musculus	119-123
21062919-1	2011	AIMS: Binary transgenic (BT) mice with doxycycline (DOX)-suppressible cardiac-specific overexpression of endothelin-1 (ET-1) exhibit progressive heart failure (HF), QRS prolongation, and death following DOX withdrawal.	Doxycycline	52-55	endothelin 1	Mus musculus	105-117
21062919-1	2011	AIMS: Binary transgenic (BT) mice with doxycycline (DOX)-suppressible cardiac-specific overexpression of endothelin-1 (ET-1) exhibit progressive heart failure (HF), QRS prolongation, and death following DOX withdrawal.	Doxycycline	52-55	endothelin 1	Mus musculus	119-123
21062919-1	2011	AIMS: Binary transgenic (BT) mice with doxycycline (DOX)-suppressible cardiac-specific overexpression of endothelin-1 (ET-1) exhibit progressive heart failure (HF), QRS prolongation, and death following DOX withdrawal.	Doxycycline	203-206	endothelin 1	Mus musculus	105-117
21062919-1	2011	AIMS: Binary transgenic (BT) mice with doxycycline (DOX)-suppressible cardiac-specific overexpression of endothelin-1 (ET-1) exhibit progressive heart failure (HF), QRS prolongation, and death following DOX withdrawal.	Doxycycline	203-206	endothelin 1	Mus musculus	119-123
21051538-4	2011	Here, we show that the phenylephrine-induced complex-1 (PEX1), also known as zinc finger transcription factor ZFP260, is essential for cardiomyocyte response to ET-1 as evidenced in cardiomyocytes with PEX1 knockdown.	Phenylephrine	23-36	endothelin 1	Mus musculus	161-165
22053184-8	2011	Thus, over-expression of endothelial ET-1 in TET-1 mice may contribute to increased glutamate-induced neurotoxicity on neuronal cells and water accumulation in inner retina leading to edema.	Glutamic Acid	84-93	endothelin 1	Mus musculus	37-41
21893986-8	2011	In this article, the molecular biology of ET-1 and its receptors in the control of renal vasculature tonicity, glomerular function, and management of water and salt reabsorption is discussed.	Water	150-155	endothelin 1	Mus musculus	42-46
21893986-8	2011	In this article, the molecular biology of ET-1 and its receptors in the control of renal vasculature tonicity, glomerular function, and management of water and salt reabsorption is discussed.	Salts	160-164	endothelin 1	Mus musculus	42-46
21893992-2	2011	ET-1 has the potential to act as an autocrine regulator of CD function since ET-1 is secreted abluminally and ET receptors are located primarily on the basolateral side of the CD cell.	Cadmium	59-61	endothelin 1	Mus musculus	0-4
21893992-2	2011	ET-1 has the potential to act as an autocrine regulator of CD function since ET-1 is secreted abluminally and ET receptors are located primarily on the basolateral side of the CD cell.	Cadmium	59-61	endothelin 1	Mus musculus	77-81
21893992-2	2011	ET-1 has the potential to act as an autocrine regulator of CD function since ET-1 is secreted abluminally and ET receptors are located primarily on the basolateral side of the CD cell.	Cadmium	176-178	endothelin 1	Mus musculus	0-4
21893992-3	2011	A large number of in vitro studies have supported this notion of an autocrine function for ET-1, demonstrating that the peptide, largely through activation of the ET(B) receptor, inhibits both sodium (Na) and water reabsorption in the CD.	Sodium	193-199	endothelin 1	Mus musculus	91-95
21893992-3	2011	A large number of in vitro studies have supported this notion of an autocrine function for ET-1, demonstrating that the peptide, largely through activation of the ET(B) receptor, inhibits both sodium (Na) and water reabsorption in the CD.	Water	209-214	endothelin 1	Mus musculus	91-95
21893992-3	2011	A large number of in vitro studies have supported this notion of an autocrine function for ET-1, demonstrating that the peptide, largely through activation of the ET(B) receptor, inhibits both sodium (Na) and water reabsorption in the CD.	Cadmium	235-237	endothelin 1	Mus musculus	91-95
21893992-4	2011	The physiologic relevance of these findings has been confirmed in vivo wherein mice with CD-specific knockout of ET-1 are hypertensive on a normal Na diet and develop worsened hypertension associated with Na retention when placed on a high-Na diet.	Cadmium	89-91	endothelin 1	Mus musculus	113-117
21893992-7	2011	The mechanisms by which ET-1 exerts its effects on CD Na and water reabsorption are being increasingly understood.	cd na	51-56	endothelin 1	Mus musculus	24-28
21893992-7	2011	The mechanisms by which ET-1 exerts its effects on CD Na and water reabsorption are being increasingly understood.	Water	61-66	endothelin 1	Mus musculus	24-28
21893992-9	2011	In addition, nitric oxide is an important modulator of ET-1 actions on the ENaC, although the mechanism by which this occurs remains to be determined.	Nitric Oxide	13-25	endothelin 1	Mus musculus	55-59
21893992-10	2011	ET-1 reduces CD water reabsorption by inhibition of vasopressin-stimulated adenylyl cyclase activity through G(i) and protein kinase C-dependent pathways, leading to a reduction in cellular cAMP levels.	Cadmium	13-15	endothelin 1	Mus musculus	0-4
21893992-10	2011	ET-1 reduces CD water reabsorption by inhibition of vasopressin-stimulated adenylyl cyclase activity through G(i) and protein kinase C-dependent pathways, leading to a reduction in cellular cAMP levels.	Water	16-21	endothelin 1	Mus musculus	0-4
21893992-10	2011	ET-1 reduces CD water reabsorption by inhibition of vasopressin-stimulated adenylyl cyclase activity through G(i) and protein kinase C-dependent pathways, leading to a reduction in cellular cAMP levels.	Cyclic AMP	190-194	endothelin 1	Mus musculus	0-4
22053184-8	2011	Thus, over-expression of endothelial ET-1 in TET-1 mice may contribute to increased glutamate-induced neurotoxicity on neuronal cells and water accumulation in inner retina leading to edema.	Water	138-143	endothelin 1	Mus musculus	37-41
21602610-3	2011	However, in the presence of S1P (10(-6) M), the BSM contractions induced by acetylcholine (ACh) and endothelin-1 (ET-1) were significantly augmented: both the ACh and ET-1 concentration-response curves were significantly shifted to the left.	Acetylcholine	76-89	endothelin 1	Mus musculus	167-171
21602610-3	2011	However, in the presence of S1P (10(-6) M), the BSM contractions induced by acetylcholine (ACh) and endothelin-1 (ET-1) were significantly augmented: both the ACh and ET-1 concentration-response curves were significantly shifted to the left.	Acetylcholine	91-94	endothelin 1	Mus musculus	167-171
21602610-3	2011	However, in the presence of S1P (10(-6) M), the BSM contractions induced by acetylcholine (ACh) and endothelin-1 (ET-1) were significantly augmented: both the ACh and ET-1 concentration-response curves were significantly shifted to the left.	Acetylcholine	159-162	endothelin 1	Mus musculus	100-112
21041306-3	2010	In previous studies, we found that endothelin-1, but not bradykinin, inhibited GIRK channels, even though both of them hydrolyze PIP(2) in cardiac myocytes, showing receptor specificity.	Phosphatidylinositol 4,5-Diphosphate	129-135	endothelin 1	Mus musculus	35-47
20197249-7	2010	Interestingly, ET-1 and MMP-9 transcriptional effects could be recreated by exposure to CO and NO, but not NO(2) or SOAs.	Carbon Monoxide	88-90	endothelin 1	Mus musculus	15-19
20690805-1	2010	We investigated the effects of the endothelin-1 (ET-1) receptor dual antagonist (Bosentan ) on the inflammatory cytokines and the chemoattractant molecules associated with breast cancer growth and the development of tumor infiltration in bone explants.	Bosentan	81-89	endothelin 1	Mus musculus	35-47
20690805-1	2010	We investigated the effects of the endothelin-1 (ET-1) receptor dual antagonist (Bosentan ) on the inflammatory cytokines and the chemoattractant molecules associated with breast cancer growth and the development of tumor infiltration in bone explants.	Bosentan	81-89	endothelin 1	Mus musculus	49-53
20703215-3	2010	In opossum kidney cells the acid stimulatory effect and the ability of endothelin-1 (ET-1) to stimulate NaDC-1 activity are both blocked by the endothelin B (ET(B)) receptor antagonist, BQ788.	endothelin b	144-156	endothelin 1	Mus musculus	85-89
20703215-3	2010	In opossum kidney cells the acid stimulatory effect and the ability of endothelin-1 (ET-1) to stimulate NaDC-1 activity are both blocked by the endothelin B (ET(B)) receptor antagonist, BQ788.	BQ 788	186-191	endothelin 1	Mus musculus	85-89
20809048-5	2010	In a separate line of investigation, we have shown that blockade of endothelin-1 (ET-1) action through the use of an endothelin-converting enzyme-1 (ECE-1) inhibitor, an established commercially available endothelin receptor antagonist or a novel quinolone-derived endothelin receptor antagonist synthesized by our group also prevents preterm labor and delivery in a mouse model.	Quinolones	247-256	endothelin 1	Mus musculus	68-80
20809048-5	2010	In a separate line of investigation, we have shown that blockade of endothelin-1 (ET-1) action through the use of an endothelin-converting enzyme-1 (ECE-1) inhibitor, an established commercially available endothelin receptor antagonist or a novel quinolone-derived endothelin receptor antagonist synthesized by our group also prevents preterm labor and delivery in a mouse model.	Quinolones	247-256	endothelin 1	Mus musculus	82-86
20860668-0	2010	Lipoxin A(4) attenuates zymosan-induced arthritis by modulating endothelin-1 and its effects.	lipoxin A4	0-9	endothelin 1	Mus musculus	64-76
20860668-0	2010	Lipoxin A(4) attenuates zymosan-induced arthritis by modulating endothelin-1 and its effects.	Zymosan	24-31	endothelin 1	Mus musculus	64-76
21063150-0	2010	Knockout of endothelin-1 in vascular endothelial cells protects against insulin resistance induced by high-salt diet in mice.	Salts	107-111	endothelin 1	Mus musculus	12-24
21063150-3	2010	Here we investigate the potential role of endothelial cell-derived ET-1 in mediating insulin resistance induced by high-salt diet.	Salts	120-124	endothelin 1	Mus musculus	67-71
20427706-1	2010	Endothelins (ETs), potent endothelium-derived mediators, stimulate formation of nitric oxide, which, in turn, protects against suicidal erythrocyte death or eryptosis, characterized by phosphatidylserine exposure at the erythrocyte surface and triggered by increase in cytosolic Ca(2+) ([Ca(2+)](i)).	Nitric Oxide	80-92	endothelin 1	Mus musculus	0-11
20427706-4	2010	Energy depletion increased [Ca(2+)](i) and phosphatidylserine-exposure, effects significantly blunted by ET1 (IC(50) approximately 100 nM) and the ETB receptor-agonist sarafotoxin 6c (IC(50) approximately 10 nM) but not by ET2 and ET3.	Phosphatidylserines	43-61	endothelin 1	Mus musculus	105-108
20234380-4	2010	Contractile responses to endothelin-1 were significantly enhanced in MCA from ApoE(-/-) mice compared with WT mice (P&lt;0.01), an effect absent in cilostazol-treated ApoE(-/-) mice.	Cilostazol	148-158	endothelin 1	Mus musculus	25-37
21053276-7	2010	ET-1 induced an increase in the percentage of spindle cells was also inhibited by U0126.	U 0126	82-87	endothelin 1	Mus musculus	0-4
20497976-6	2010	Diabetes mellitus increased cardiac ET-1 expression in wild-type mice, leading to mitochondrial disruption and myofibril disarray through the generation of superoxide.	Superoxides	156-166	endothelin 1	Mus musculus	36-40
20516393-0	2010	Rosiglitazone attenuates endothelin-1-induced vasoconstriction by upregulating endothelial expression of endothelin B receptor.	Rosiglitazone	0-13	endothelin 1	Mus musculus	25-37
20516393-3	2010	The present study aimed to examine the molecular mechanism for the anti-vasoconstrictive effects of rosiglitazone in response to endothelin (ET) 1.	Rosiglitazone	100-113	endothelin 1	Mus musculus	129-146
20308920-9	2010	The blunted endothelin-1 contractile response of small arteries found in transgenic+salt mice was partially restored by ET(A)RA and completely prevented by dual ET(A/B)R antagonism.	Salts	84-88	endothelin 1	Mus musculus	12-24
20181666-10	2010	Furthermore, increases observed in gene expression in amiloride binding protein 1, vascular cell adhesion molecule-1, and endothelin 1 could explain the salt-sensitive hypertension that can follow AKI.	Salts	153-157	endothelin 1	Mus musculus	122-134
20628431-5	2010	Although ABT-627 was devoid of any effect in TGF mice, it virtually abolished the ET-1-induced contraction and NO release in wild-type (WT) littermates.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	9-12	endothelin 1	Mus musculus	82-86
20200406-3	2010	We report here that several broad-spectrum HDAC inhibitors, including TSA and SAHA, suppressed the LPS-induced mRNA expression of the proinflammatory mediators Edn-1, Ccl-7/MCP-3, and Il-12p40 but amplified the expression of the proatherogenic factors Cox-2 and Pai-1/serpine1 in primary mouse BMM.	trichostatin A	70-73	endothelin 1	Mus musculus	160-165
20308920-9	2010	The blunted endothelin-1 contractile response of small arteries found in transgenic+salt mice was partially restored by ET(A)RA and completely prevented by dual ET(A/B)R antagonism.	Radium	125-127	endothelin 1	Mus musculus	12-24
20200406-3	2010	We report here that several broad-spectrum HDAC inhibitors, including TSA and SAHA, suppressed the LPS-induced mRNA expression of the proinflammatory mediators Edn-1, Ccl-7/MCP-3, and Il-12p40 but amplified the expression of the proatherogenic factors Cox-2 and Pai-1/serpine1 in primary mouse BMM.	Vorinostat	78-82	endothelin 1	Mus musculus	160-165
20308920-12	2010	CONCLUSION: Transgenic+salt mice with endothelin-1 overexpression have structural alterations of mesenteric resistance vessels, endothelial dysfunction due to reduced nitric oxide bioavailability, a reduced responsiveness to endothelin-1, and enhanced vascular NADPH oxidase activity.	Salts	23-27	endothelin 1	Mus musculus	38-50
20308920-12	2010	CONCLUSION: Transgenic+salt mice with endothelin-1 overexpression have structural alterations of mesenteric resistance vessels, endothelial dysfunction due to reduced nitric oxide bioavailability, a reduced responsiveness to endothelin-1, and enhanced vascular NADPH oxidase activity.	Salts	23-27	endothelin 1	Mus musculus	225-237
20308920-12	2010	CONCLUSION: Transgenic+salt mice with endothelin-1 overexpression have structural alterations of mesenteric resistance vessels, endothelial dysfunction due to reduced nitric oxide bioavailability, a reduced responsiveness to endothelin-1, and enhanced vascular NADPH oxidase activity.	Nitric Oxide	167-179	endothelin 1	Mus musculus	38-50
20308920-15	2010	The present study provides the first in-vivo demonstration that endothelin-1 overexpression when associated with high-salt intake results in enhanced endothelial dysfunction and vascular remodeling of resistance vessels, and contributes to elevated BP, via ET(A)R and ET(B)R.	Salts	118-122	endothelin 1	Mus musculus	64-76
20093625-6	2010	Although (-)-epicatechin significantly reduced F(2)-isoprostane, superoxide, and endothelin-1 production (P&lt;0.05 versus control ApoE(-/-) mice), it had no significant effect on lesion size.	Catechin	9-24	endothelin 1	Mus musculus	81-93
20631886-10	2010	The potency of I(K(Ado)) inhibition by GqPCRs was different with that observed in acetylcholine-activated GIRK currents (I(K(ACh))) (endothelin-1&gt;phenylephrine&gt;bradykinin).	Acetylcholine	82-95	endothelin 1	Mus musculus	133-145
20631886-10	2010	The potency of I(K(Ado)) inhibition by GqPCRs was different with that observed in acetylcholine-activated GIRK currents (I(K(ACh))) (endothelin-1&gt;phenylephrine&gt;bradykinin).	Phenylephrine	149-162	endothelin 1	Mus musculus	133-145
20042899-8	2010	Low dose of ET-1 could potentiate cinnamaldehyde-induced nociception.	cinnamaldehyde	34-48	endothelin 1	Mus musculus	12-16
19767294-11	2010	The selective ET(B) endothelin receptor antagonist BQ788 abolished the downregulation of BMPER expression by endothelin-1.	BQ 788	51-56	endothelin 1	Mus musculus	109-121
19726735-7	2010	Edn1, Apoa1, and Cited1 were primarily regulated by PGR-A as verified by additional RT-PCR analyses, suppression by the PGR antagonist RU486, and the lack of induction by protein kinase A, protein kinase C, or epidermal growth factor (EGF)-like factors pathways.	Mifepristone	135-140	endothelin 1	Mus musculus	0-4
19909737-6	2010	Enzyme-linked immunosorbent assay and radio-immunity assay showed that treatment with neferine alleviated bleomycin-induced increase of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and endothelin-1 in plasma or in tissue.	Bleomycin	106-115	endothelin 1	Mus musculus	229-241
19707218-8	2009	Therefore, ET-1-induced AQP-4 expression and cerebral water accumulation are the key factors in brain edema associated with acute water intoxication.	Water	54-59	endothelin 1	Mus musculus	11-15
20141403-4	2010	Either the removal of prior serum and heparin deprivation or NO synthase inhibition by L-NAME unmasked an inhibitory effect of TGFbeta1 on ET-1 production.	NG-Nitroarginine Methyl Ester	87-93	endothelin 1	Mus musculus	139-143
20141403-5	2010	Indomethacin abolished the TGFbeta1 inhibitory action on L-NAME-increased ET-1 production.	Indomethacin	0-12	endothelin 1	Mus musculus	74-78
20141403-5	2010	Indomethacin abolished the TGFbeta1 inhibitory action on L-NAME-increased ET-1 production.	NG-Nitroarginine Methyl Ester	57-63	endothelin 1	Mus musculus	74-78
20141403-7	2010	This increase in PGI(2) partly accounts for the inhibitory action of TGFbeta1 on ET-1 secretion.	Epoprostenol	17-23	endothelin 1	Mus musculus	81-85
20039876-8	2010	Intracellular Ca(2+) release in response to endothelin-1 was measured by using Fluo-4.	Fluo 4	79-85	endothelin 1	Mus musculus	44-56
20039876-12	2010	Moreover, blebbistatin impaired silicone wrinkle formation, reduced collagen gel contraction and blocked endothelin-1-induced intracellular Ca(2+) release.	blebbistatin	10-22	endothelin 1	Mus musculus	105-117
19858408-5	2009	[Ala1, 3,11,15]-endothelin 1, an ETB agonist, increased ARNA that was greater than that induced by ET-1 in WT mice only.	arna	56-60	endothelin 1	Mus musculus	16-28
19858408-6	2009	[Ala1, 3,11,15]-endothelin 1-induced increases in ARNA were abolished by chelerythrine, a protein kinase C inhibitor, but not by H89, a protein kinase A inhibitor.	ala1, 3,11,15	1-14	endothelin 1	Mus musculus	16-28
19858408-6	2009	[Ala1, 3,11,15]-endothelin 1-induced increases in ARNA were abolished by chelerythrine, a protein kinase C inhibitor, but not by H89, a protein kinase A inhibitor.	chelerythrine	73-86	endothelin 1	Mus musculus	16-28
19858408-8	2009	Substance P release from the renal pelvis was increased by [Ala1, 3,11,15]-endothelin 1 in WT mice only, and the increase was abolished by chelerythrine but not by H89.	ala1, 3,11,15]	60-74	endothelin 1	Mus musculus	75-87
19858408-10	2009	Our data show that ET1 increases ARNA via activation of ETB, whereas ETA counterbalances ETB in WT but not in TRPV1-null mutant mice, suggesting that TRPV1 mediates ETB-dependent increases in ARNA, diuresis, and natriuresis possibly via the protein kinase C pathway.	arna	33-37	endothelin 1	Mus musculus	19-22
20921820-6	2010	RESULTS: Thirty-six genes, including Edn1 and Agpt2, were identified as candidate responsive genes in irradiated mouse bone marrow treated with Zn-yeast by showing a greater than three-fold change compared with control (no irradiation and no Zn-yeast) mice.	Zinc	144-146	endothelin 1	Mus musculus	37-41
20921820-6	2010	RESULTS: Thirty-six genes, including Edn1 and Agpt2, were identified as candidate responsive genes in irradiated mouse bone marrow treated with Zn-yeast by showing a greater than three-fold change compared with control (no irradiation and no Zn-yeast) mice.	Zinc	242-244	endothelin 1	Mus musculus	37-41
19707218-9	2009	The V(2) receptor antagonist, OPC-31260, may be one of the effective drugs for the early treatment of ET-1-induced cytotoxic edema and brain injury.	mozavaptan	30-39	endothelin 1	Mus musculus	102-106
19806261-7	2009	This disruption of the ET-1 axis was confirmed in an ex vivo mouse aortic ring model, and resulted in endothelial cell proliferation that could be abrogated by ETAR-siRNA and the selective ETAR-antagonist BQ-123.	cyclo(Trp-Asp-Pro-Val-Leu)	205-211	endothelin 1	Mus musculus	23-27
19940641-2	2009	The purpose of this study was to determine the responsiveness of PPV in in vivo BALB/c mouse to intraportal injections of the 3 major vasoconstrictors of angiotensin II, norepinephrine, and endothelin-1 in comparison with that in Sprague-Dawley rats.	DOP protocol	65-68	endothelin 1	Mus musculus	190-202
19106220-0	2009	Endogenous aldosterone contributes to acute angiotensin II-stimulated plasminogen activator inhibitor-1 and preproendothelin-1 expression in heart but not aorta.	Aldosterone	11-22	endothelin 1	Mus musculus	108-126
19564617-3	2009	We provide evidence that at least 3 different molecular pathways contribute to the transduction of itch responses to different pruritogens: 1) histamine requires the function of both PLCbeta3 and the TRPV1 channel; 2) serotonin, or a selective agonist, alpha-methyl-serotonin (alpha-Me-5-HT), requires the presence of PLCbeta3 but not TRPV1, and 3) endothelin-1 (ET-1) does not require either PLCbeta3 or TRPV1.	Serotonin	218-227	endothelin 1	Mus musculus	349-361
19564617-3	2009	We provide evidence that at least 3 different molecular pathways contribute to the transduction of itch responses to different pruritogens: 1) histamine requires the function of both PLCbeta3 and the TRPV1 channel; 2) serotonin, or a selective agonist, alpha-methyl-serotonin (alpha-Me-5-HT), requires the presence of PLCbeta3 but not TRPV1, and 3) endothelin-1 (ET-1) does not require either PLCbeta3 or TRPV1.	Serotonin	218-227	endothelin 1	Mus musculus	363-367
19403649-3	2009	We recently found reduced renal vascular reactivity to angiotensin II (ANG II), endothelin-1 (ET-1), and norepinephrine (NE) in the presence of the broad ADPR cyclase inhibitor nicotinamide.	Niacinamide	177-189	endothelin 1	Mus musculus	80-92
19403649-3	2009	We recently found reduced renal vascular reactivity to angiotensin II (ANG II), endothelin-1 (ET-1), and norepinephrine (NE) in the presence of the broad ADPR cyclase inhibitor nicotinamide.	Niacinamide	177-189	endothelin 1	Mus musculus	94-98
19202571-1	2009	BACKGROUND: Ingestion by mice of dextran sodium sulfate (DSS) induces colonic vasoconstriction and inflammation, with some of the effects potentially mediated by the vasoconstrictor endothelin-1 (ET-1).	dextran sodium sulfate	33-55	endothelin 1	Mus musculus	182-194
19202571-1	2009	BACKGROUND: Ingestion by mice of dextran sodium sulfate (DSS) induces colonic vasoconstriction and inflammation, with some of the effects potentially mediated by the vasoconstrictor endothelin-1 (ET-1).	dextran sodium sulfate	33-55	endothelin 1	Mus musculus	196-200
19202571-1	2009	BACKGROUND: Ingestion by mice of dextran sodium sulfate (DSS) induces colonic vasoconstriction and inflammation, with some of the effects potentially mediated by the vasoconstrictor endothelin-1 (ET-1).	dss	57-60	endothelin 1	Mus musculus	182-194
19202571-1	2009	BACKGROUND: Ingestion by mice of dextran sodium sulfate (DSS) induces colonic vasoconstriction and inflammation, with some of the effects potentially mediated by the vasoconstrictor endothelin-1 (ET-1).	dss	57-60	endothelin 1	Mus musculus	196-200
19202571-2	2009	METHODS: In this study, mice given 5% 40 kD DSS for 5-6 days had elevated colonic immunostaining for ET-1 and platelet endothelial cell adhesion molecule-1 (PECAM-1).	dss	44-47	endothelin 1	Mus musculus	101-105
19202571-5	2009	Daily administration of the endothelin converting enzyme inhibitor SM-19712 (15 mg/kg) attenuated DSS-induced increases in colonic immunostaining of ET-1 and PECAM-1.	SM 19712	67-75	endothelin 1	Mus musculus	149-153
19202571-5	2009	Daily administration of the endothelin converting enzyme inhibitor SM-19712 (15 mg/kg) attenuated DSS-induced increases in colonic immunostaining of ET-1 and PECAM-1.	dss	98-101	endothelin 1	Mus musculus	149-153
19179430-9	2009	Conversely, antagonism of ET-1/endothelin-A receptors with BQ-123 reduced ABP significantly and comparably in both genotypes (by approximately 11 mm Hg).	cyclo(Trp-Asp-Pro-Val-Leu)	59-65	endothelin 1	Mus musculus	26-30
19564617-3	2009	We provide evidence that at least 3 different molecular pathways contribute to the transduction of itch responses to different pruritogens: 1) histamine requires the function of both PLCbeta3 and the TRPV1 channel; 2) serotonin, or a selective agonist, alpha-methyl-serotonin (alpha-Me-5-HT), requires the presence of PLCbeta3 but not TRPV1, and 3) endothelin-1 (ET-1) does not require either PLCbeta3 or TRPV1.	Histamine	143-152	endothelin 1	Mus musculus	349-361
19564617-3	2009	We provide evidence that at least 3 different molecular pathways contribute to the transduction of itch responses to different pruritogens: 1) histamine requires the function of both PLCbeta3 and the TRPV1 channel; 2) serotonin, or a selective agonist, alpha-methyl-serotonin (alpha-Me-5-HT), requires the presence of PLCbeta3 but not TRPV1, and 3) endothelin-1 (ET-1) does not require either PLCbeta3 or TRPV1.	Histamine	143-152	endothelin 1	Mus musculus	363-367
19106220-5	2009	Ang II-stimulated PAI-1 (P &lt; 0.001) and ppET-1 expression (P = 0.01) was diminished in the heart of AS(-/-) mice; treatment with aldosterone for 4 h or 7 d restored PAI-1 and ppET-1 mRNA responsiveness to Ang II in the heart.	Aldosterone	132-143	endothelin 1	Mus musculus	43-49
19106220-5	2009	Ang II-stimulated PAI-1 (P &lt; 0.001) and ppET-1 expression (P = 0.01) was diminished in the heart of AS(-/-) mice; treatment with aldosterone for 4 h or 7 d restored PAI-1 and ppET-1 mRNA responsiveness to Ang II in the heart.	Aldosterone	132-143	endothelin 1	Mus musculus	178-184
19106220-9	2009	Endogenous aldosterone contributes to the acute stimulatory effect of Ang II on PAI-1 and ppET-1 mRNA expression in the heart; renin activity correlates with basal profibrotic gene expression in the kidney.	Aldosterone	11-22	endothelin 1	Mus musculus	90-96
19230825-4	2009	Increased ET-1 level was observed in the TET-1 brain infarct core after transient MCAO.	tetramethylenedisulfotetramine	41-44	endothelin 1	Mus musculus	10-14
19230825-9	2009	Taken together, endothelial ET-1 over-expression and ETA receptor activation contributes to the increased oxidative stress, water accumulation and BBB breakdown after transient MCAO leading to more severe neurological deficit and increased infarct.	Water	124-129	endothelin 1	Mus musculus	28-32
19150882-6	2009	GEE-mediated increases in vascular ROS were attenuated by Tempol-treatment, as were MMP-2 and TIMP-2; whereas BQ-123 ameliorated GEE-induced vascular expression of MMP-9, MMP-2, ROS, and ET-1.	glycine ethyl ester	0-3	endothelin 1	Mus musculus	187-191
19162127-6	2009	The stimulatory effect of ET-1 on IL-6 secretion was abolished by actinomycin D and ET-1 induced an increase in IL-6 mRNA levels.	Dactinomycin	66-79	endothelin 1	Mus musculus	26-30
19162127-7	2009	ET-1 was able to enhance the IL-6 promoter activity and its stimulatory effect was inhibited by GF109203X, U0126, salicylate, dominant negative CREB and mithramycin A.	U 0126	107-112	endothelin 1	Mus musculus	0-4
19162127-7	2009	ET-1 was able to enhance the IL-6 promoter activity and its stimulatory effect was inhibited by GF109203X, U0126, salicylate, dominant negative CREB and mithramycin A.	Salicylates	114-124	endothelin 1	Mus musculus	0-4
19162127-7	2009	ET-1 was able to enhance the IL-6 promoter activity and its stimulatory effect was inhibited by GF109203X, U0126, salicylate, dominant negative CREB and mithramycin A.	mithramycin A	153-166	endothelin 1	Mus musculus	0-4
19074677-9	2009	The ET(A) receptor antagonist atrasentan completely abolished responses to ET-1 in aorta and mesenteric vessels, whereas the ERK1/2 inhibitor PD-98059 abrogated increased contractions to ET-1 in arteries from TNF-alpha-infused IL-10(-/-) mice.	Atrasentan	30-40	endothelin 1	Mus musculus	75-79
19074677-9	2009	The ET(A) receptor antagonist atrasentan completely abolished responses to ET-1 in aorta and mesenteric vessels, whereas the ERK1/2 inhibitor PD-98059 abrogated increased contractions to ET-1 in arteries from TNF-alpha-infused IL-10(-/-) mice.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	142-150	endothelin 1	Mus musculus	187-191
19074677-11	2009	These data demonstrate that IL-10 counteracts ET(A)-mediated vascular responses to ET-1, as well as activation of the ERK1/2 pathway.	et(a)	46-51	endothelin 1	Mus musculus	83-87
18987301-5	2009	The pressor responses to big endothelin-1 were significantly reduced by the neutral endopeptidase inhibitor thiorphan (dl-3-mercapto-2-benzylpropanoylglycine) (1 mg/kg) or the endothelin-converting enzyme inhibitor CGS 35066 [alpha-[(S)-(phosphonomethyl)amino]-3-dibenzofuranopropanoic acid] (0.1 mg/kg).	Thiorphan	108-117	endothelin 1	Mus musculus	29-41
18987301-5	2009	The pressor responses to big endothelin-1 were significantly reduced by the neutral endopeptidase inhibitor thiorphan (dl-3-mercapto-2-benzylpropanoylglycine) (1 mg/kg) or the endothelin-converting enzyme inhibitor CGS 35066 [alpha-[(S)-(phosphonomethyl)amino]-3-dibenzofuranopropanoic acid] (0.1 mg/kg).	mercapto-2-benzylpropanoylglycine)	124-158	endothelin 1	Mus musculus	29-41
18987301-8	2009	Finally, intravenous administration of big endothelin-1 induced Suc-Val-Pro-Phe(P)-(OPh)(2)-sensitive increases in plasma-immunoreactive levels of endothelin-1 (1-31) and endothelin-1.	suc-val-pro-phe	64-79	endothelin 1	Mus musculus	43-55
18987301-8	2009	Finally, intravenous administration of big endothelin-1 induced Suc-Val-Pro-Phe(P)-(OPh)(2)-sensitive increases in plasma-immunoreactive levels of endothelin-1 (1-31) and endothelin-1.	suc-val-pro-phe	64-79	endothelin 1	Mus musculus	147-159
18987301-8	2009	Finally, intravenous administration of big endothelin-1 induced Suc-Val-Pro-Phe(P)-(OPh)(2)-sensitive increases in plasma-immunoreactive levels of endothelin-1 (1-31) and endothelin-1.	suc-val-pro-phe	64-79	endothelin 1	Mus musculus	147-159
18987301-5	2009	The pressor responses to big endothelin-1 were significantly reduced by the neutral endopeptidase inhibitor thiorphan (dl-3-mercapto-2-benzylpropanoylglycine) (1 mg/kg) or the endothelin-converting enzyme inhibitor CGS 35066 [alpha-[(S)-(phosphonomethyl)amino]-3-dibenzofuranopropanoic acid] (0.1 mg/kg).	cysteinylglycine	215-218	endothelin 1	Mus musculus	29-41
18987301-5	2009	The pressor responses to big endothelin-1 were significantly reduced by the neutral endopeptidase inhibitor thiorphan (dl-3-mercapto-2-benzylpropanoylglycine) (1 mg/kg) or the endothelin-converting enzyme inhibitor CGS 35066 [alpha-[(S)-(phosphonomethyl)amino]-3-dibenzofuranopropanoic acid] (0.1 mg/kg).	alpha-[(s)-(phosphonomethyl)amino]-3-dibenzofuranopropanoic acid	226-290	endothelin 1	Mus musculus	29-41
18987301-6	2009	In contrast, the responses to endothelin-1 (1-31) were abolished by thiorphan but unaffected by CGS 35066.	Thiorphan	68-77	endothelin 1	Mus musculus	30-42
18987301-7	2009	In addition, Suc-Val-Pro-Phe(P)(OPh)(2) (20-40 mg/kg) reduced, by more than 60%, the hemodynamic response to big endothelin-1 but not to endothelin-1 (1-31) and endothelin-1.	suc-val-pro-phe	13-28	endothelin 1	Mus musculus	113-125
19033447-0	2009	Endothelin-1 inhibits thick ascending limb transport via Akt-stimulated nitric oxide production.	Nitric Oxide	72-84	endothelin 1	Mus musculus	0-12
18524861-9	2008	The effect of IL-1beta on ET-1 release could be partially inhibited by pretreatment of IMCD-3 cells with an inhibitor of NF-kappaB activation (BAY 11-7082).	3-(4-methylphenylsulfonyl)-2-propenenitrile	143-154	endothelin 1	Mus musculus	26-30
18756537-0	2009	Connexin43 is involved in the effect of endothelin-1 on astrocyte proliferation and glucose uptake.	Glucose	84-91	endothelin 1	Mus musculus	40-52
18756537-1	2009	In previous studies, we showed that endothelin-1 increased astrocyte proliferation and glucose uptake.	Glucose	87-94	endothelin 1	Mus musculus	36-48
18756537-11	2009	In conclusion, our results indicate that connexin43 participates in the effects of endothelin-1 on glucose uptake and proliferation in astrocytes.	Glucose	99-106	endothelin 1	Mus musculus	83-95
19033447-1	2009	Endothelin-1 inhibits sodium reabsorption in the thick ascending limb (THAL) via stimulation of nitric oxide (NO) production.	Nitric Oxide	96-108	endothelin 1	Mus musculus	0-12
19033447-7	2009	Wortmannin (150 nmol/liter), a PI3K inhibitor, reduced endothelin-1-stimulated NO by 83% (0.49 +/- 0.13 versus 3.31 +/- 0.49 fluorescence units/min for endothelin-1 alone; p &lt; 0.006; n = 5).	Wortmannin	0-10	endothelin 1	Mus musculus	55-67
19033447-7	2009	Wortmannin (150 nmol/liter), a PI3K inhibitor, reduced endothelin-1-stimulated NO by 83% (0.49 +/- 0.13 versus 3.31 +/- 0.49 fluorescence units/min for endothelin-1 alone; p &lt; 0.006; n = 5).	Wortmannin	0-10	endothelin 1	Mus musculus	152-164
18632188-2	2008	The intraplantar injection of BQ-123, but not BQ-788, significantly inhibited carrageenan-, PAF-, ET-1- and bradykinin-induced paw edema formation.	cyclo(Trp-Asp-Pro-Val-Leu)	30-36	endothelin 1	Mus musculus	98-102
18758502-8	2008	The combined ETA/ETB-receptor antagonist LU 302872 abolished inflammation and interstitial fibrosis in L-NAME-treated ET1tg mice.	LU 224332	41-50	endothelin 1	Mus musculus	118-121
18758502-8	2008	The combined ETA/ETB-receptor antagonist LU 302872 abolished inflammation and interstitial fibrosis in L-NAME-treated ET1tg mice.	NG-Nitroarginine Methyl Ester	103-109	endothelin 1	Mus musculus	118-121
18758504-1	2008	Endothelin-1 (ET-1) is implicated in the development of endothelial dysfunction through the generation of reactive oxygen species by NADPH oxidase activation.	Reactive Oxygen Species	106-129	endothelin 1	Mus musculus	0-12
18758504-1	2008	Endothelin-1 (ET-1) is implicated in the development of endothelial dysfunction through the generation of reactive oxygen species by NADPH oxidase activation.	Reactive Oxygen Species	106-129	endothelin 1	Mus musculus	14-18
18758504-8	2008	Overnight exposure of aortic rings to ET-1 resulted in a statistically significant endothelial dysfunction characterized by a reduced maximal relaxation response to ACh compared with that of untreated rings (Emax 57% +/- 3% versus 82% +/- 4%).	Acetylcholine	165-168	endothelin 1	Mus musculus	38-42
18758506-5	2008	In our previous work, we have shown that blockade of ET-1 synthesis through the use of the metalloproteinase inhibitor phosphoramidon results in control of preterm labor.	phosphoramidon	119-133	endothelin 1	Mus musculus	53-57
19967049-0	2008	Expression of endothelin-1 and its receptors in Cisplatin-induced acute renal failure in mice.	Cisplatin	48-57	endothelin 1	Mus musculus	14-26
19967049-3	2008	This study was, therefore, undertaken to investigate changes in renal expression of ET-1 and its receptors in nephrotoxic ARF induced by cisplatin.	Cisplatin	137-146	endothelin 1	Mus musculus	84-88
19967049-6	2008	Three days after treatment, ET-1 transcript in cisplatin-treated mice was thirteen times higher than that in controls, whereas ET-1 peptide was increased by 1.5-fold.	Cisplatin	47-56	endothelin 1	Mus musculus	28-32
18632188-10	2008	Our findings indicate that ET(A), but not ET(B), selective ET-1 antagonists are capable of preventing the acute inflammatory responses induced by carrageenan, PAF, BK and ET-1.	Carrageenan	146-157	endothelin 1	Mus musculus	59-63
18523267-9	2008	Moreover, histamine release upon stimulation of BMMCs with endothelin-1 was reduced in K(Ca)3.1(-/-) cells.	Histamine	10-19	endothelin 1	Mus musculus	59-71
18387943-10	2008	Finally, we show that 1,2-dioleoyl-sn-glycerol mimics the effect of PMA to drive PKCdelta to caveolae and increase PKCdelta-Tyr(311) phosphorylation, whereas G protein-coupled receptor agonists such as norepinephrine and endothelin-1 do not.	1,2-Dioleoyl-sn-glycerol	22-46	endothelin 1	Mus musculus	221-233
18387943-11	2008	These results suggest that norepinephrine and endothelin-1 increase 1,2-dioleoyl-sn-glycerol accumulation and activate PKCdelta exclusively in non-caveolae membranes.	1,2-Dioleoyl-sn-glycerol	68-92	endothelin 1	Mus musculus	46-58
18516094-0	2008	DOCA-salt treatment enhances responses to endothelin-1 in murine corpus cavernosum.	Desoxycorticosterone Acetate	0-4	endothelin 1	Mus musculus	42-54
18516094-0	2008	DOCA-salt treatment enhances responses to endothelin-1 in murine corpus cavernosum.	Salts	5-9	endothelin 1	Mus musculus	42-54
18516095-5	2008	Valsartan, an angiotensin receptor blocker (ARB), abolished the hypertension in CD ET-1 KO mice during normal Na intake.	Valsartan	0-9	endothelin 1	Mus musculus	83-87
18516095-8	2008	Spironolactone, an aldosterone antagonist, also normalized blood pressure in CD ET-1 KO mice during normal Na intake, whereas high-Na intake + spironolactone raised blood pressure only in CD ET-1 KO animals.	Spironolactone	0-14	endothelin 1	Mus musculus	80-84
18516095-8	2008	Spironolactone, an aldosterone antagonist, also normalized blood pressure in CD ET-1 KO mice during normal Na intake, whereas high-Na intake + spironolactone raised blood pressure only in CD ET-1 KO animals.	Spironolactone	143-157	endothelin 1	Mus musculus	191-195
18516102-6	2008	Pretreatment with the ETB-receptor antagonist BQ788 (1 micromol/L) was able to significantly attenuate ET-1-mediated apoptosis in RGC-5 cells.	BQ 788	46-51	endothelin 1	Mus musculus	103-107
18443239-6	2008	Moreover, overexpressing a dominant negative form of RGS4 diminished the inhibitory effects of atrial natriuretic peptide on endothelin-1-stimulated inositol 1,4,5-triphosphate production, [(3)H]leucine incorporation, and atrial natriuretic peptide gene expression.	Inositol 1,4,5-Trisphosphate	149-176	endothelin 1	Mus musculus	125-137
18391099-5	2008	N(G)-nitro-l-arginine methyl ester increased BP in control mice by 30 mm Hg and 10 mm Hg in collecting duct-specific deletion of endothelin-1 knockout mice, thereby abolishing the difference in systolic BP between the groups.	NG-Nitroarginine Methyl Ester	0-34	endothelin 1	Mus musculus	129-141
18391099-13	2008	These data demonstrate that collecting duct-derived endothelin-1 is important in the following: (1) chronic N(G)-nitro-l-arginine methyl ester-induced hypertension; (2) full expression of pressure-dependent changes in sodium excretion; and (3) control of inner medullary NOS1 and NOS3 activity.	NG-Nitroarginine Methyl Ester	108-142	endothelin 1	Mus musculus	52-64
18391099-13	2008	These data demonstrate that collecting duct-derived endothelin-1 is important in the following: (1) chronic N(G)-nitro-l-arginine methyl ester-induced hypertension; (2) full expression of pressure-dependent changes in sodium excretion; and (3) control of inner medullary NOS1 and NOS3 activity.	Sodium	218-224	endothelin 1	Mus musculus	52-64
18212270-5	2008	When AHR KO mice residing at 1632 m were exposed to the partial pressure of inspired oxygen (PIO(2)) at sea level for 11 days, blood pressure declined to levels measured at 225 m. Although plasma ET-1 in AHR KO mice was significantly elevated at 1632 m and decreased at 225 m and sea level PIO(2), pulmonary prepro-ET-1 mRNA was significantly reduced at 1632 m and decreased further at 225 m and sea level PIO(2).	Oxygen	85-91	endothelin 1	Mus musculus	196-200
18275971-2	2008	In adult mouse ventricular cardiomyocytes loaded with indo-1, ET-1 induced a sustained negative inotropic effect (NIE) in association with decreases in Ca(2+) transients.	Indomethacin	54-58	endothelin 1	Mus musculus	62-66
18275971-4	2008	A nonselective protein kinase C (PKC) inhibitor, GF109203X, inhibited the ET-1-induced decreases in Ca(2+) transients and cell shortening in concentration-dependent manners, whereas a selective Ca(2+)-dependent PKC inhibitor, Go6976, did not affect the ET-1-induced effects.	bisindolylmaleimide I	49-58	endothelin 1	Mus musculus	74-78
18275971-4	2008	A nonselective protein kinase C (PKC) inhibitor, GF109203X, inhibited the ET-1-induced decreases in Ca(2+) transients and cell shortening in concentration-dependent manners, whereas a selective Ca(2+)-dependent PKC inhibitor, Go6976, did not affect the ET-1-induced effects.	bisindolylmaleimide I	49-58	endothelin 1	Mus musculus	253-257
18275971-4	2008	A nonselective protein kinase C (PKC) inhibitor, GF109203X, inhibited the ET-1-induced decreases in Ca(2+) transients and cell shortening in concentration-dependent manners, whereas a selective Ca(2+)-dependent PKC inhibitor, Go6976, did not affect the ET-1-induced effects.	Go 6976	226-232	endothelin 1	Mus musculus	74-78
18275971-5	2008	A phospholipase Cbeta inhibitor, U73122, and an inhibitor of phospholipase D, C(2)-ceramide, partially, but significantly, attenuated the ET-1-induced effects.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	33-39	endothelin 1	Mus musculus	138-142
18275971-5	2008	A phospholipase Cbeta inhibitor, U73122, and an inhibitor of phospholipase D, C(2)-ceramide, partially, but significantly, attenuated the ET-1-induced effects.	(2)-ceramide	79-91	endothelin 1	Mus musculus	138-142
18275971-7	2008	Taken together, these results indicate that activation of a Ca(2+)-independent PKC isozyme by 1,2-DAG, which is generated by phospholipase Cbeta and phospholipase D activation and inactivated by phosphorylation via DAG kinase, is responsible for the ET-1-induced decreases in Ca(2+) transients and cell shortening in mouse ventricular cardiomyocytes.	1,2-diacylglycerol	94-101	endothelin 1	Mus musculus	250-254
18026125-6	2008	JTE-013 inhibited not only S1P-induced vasoconstriction, but also KCl-, U46619- and endothelin-1-induced constriction.	JTE 013	0-7	endothelin 1	Mus musculus	84-96
18172614-2	2008	In the presence of SEA0400, a specific inhibitor of the Na+-Ca2+ exchanger, endothelin-1 produced positive inotropy.	SEA 0400	19-26	endothelin 1	Mus musculus	76-88
18172614-3	2008	Endothelin-1, when applied to cardiomyocytes in the presence of SEA0400, did not change the peak amplitude of the Ca2+ transient but increased intracellular pH and Ca2+ sensitivity of contractile proteins.	SEA 0400	64-71	endothelin 1	Mus musculus	0-12
18172614-4	2008	On the other hand, in the presence of dimethylamiloride (DMA), a specific inhibitor of the Na+-H+ exchanger, endothelin-1 produced negative inotropy.	5-dimethylamiloride	38-55	endothelin 1	Mus musculus	109-121
18172614-4	2008	On the other hand, in the presence of dimethylamiloride (DMA), a specific inhibitor of the Na+-H+ exchanger, endothelin-1 produced negative inotropy.	5-dimethylamiloride	57-60	endothelin 1	Mus musculus	109-121
18172614-5	2008	In cardiomyocytes, in the presence of DMA, endothelin-1 produced a decrease in peak amplitude of the Ca2+ transient.	5-dimethylamiloride	38-41	endothelin 1	Mus musculus	43-55
18172614-6	2008	In the presence of both DMA and SEA0400, endothelin-1 produced neither positive nor negative inotropy.	SEA 0400	32-39	endothelin 1	Mus musculus	41-53
17975115-4	2008	TCDD induced mRNA expression of genes associated with ECM remodeling (matrix metalloproteinase 9 and 13, preproendothelin-1 [preproET-1]), cardiac hypertrophy (atrial natriuretic peptide, beta-myosin heavy chain, osteopontin), and aryl hydrocarbon receptor (AHR) activation (cytochrome P4501A1, AHR repressor).	Polychlorinated Dibenzodioxins	0-4	endothelin 1	Mus musculus	105-123
17975115-4	2008	TCDD induced mRNA expression of genes associated with ECM remodeling (matrix metalloproteinase 9 and 13, preproendothelin-1 [preproET-1]), cardiac hypertrophy (atrial natriuretic peptide, beta-myosin heavy chain, osteopontin), and aryl hydrocarbon receptor (AHR) activation (cytochrome P4501A1, AHR repressor).	Polychlorinated Dibenzodioxins	0-4	endothelin 1	Mus musculus	125-135
18270470-6	2008	BQ-123 (3 and 10 nmol/site) inhibited licking induced by ET-1 (10 pmol/site).	cyclo(Trp-Asp-Pro-Val-Leu)	0-6	endothelin 1	Mus musculus	57-61
18584528-9	2008	An increase in Isc was caused by chloride ion (Cl(-)) secretion because Isc induced by ET-1 was blocked by bumetanide and Cl(- -) free conditions.	Chlorides	33-41	endothelin 1	Mus musculus	87-91
18584528-9	2008	An increase in Isc was caused by chloride ion (Cl(-)) secretion because Isc induced by ET-1 was blocked by bumetanide and Cl(- -) free conditions.	Bumetanide	107-117	endothelin 1	Mus musculus	87-91
17898123-2	2007	In this context, whether ET-1 modulates hydroxyl radical (*OH) formation and the function of ROS/*OH in obesity is not known.	Hydroxyl Radical	40-56	endothelin 1	Mus musculus	25-29
17898123-4	2007	Hydroxyl radical formation was detected ex vivo using terephthalic acid in intact aortic rings and the involvement of ROS in ET-1-mediated vasoreactivity was analyzed using the antioxidant EPC-K1, a combination of alpha-tocopherol and ascorbic acid.	Reactive Oxygen Species	118-121	endothelin 1	Mus musculus	125-129
17885093-0	2007	The inducible nitric-oxide synthase modulates endothelin-1-dependent release of prostacyclin and inhibition of platelet aggregation ex vivo in the mouse.	Epoprostenol	80-92	endothelin 1	Mus musculus	46-58
17913832-0	2007	Role of prostaglandins in collecting duct-derived endothelin-1 regulation of blood pressure and water excretion.	Prostaglandins	8-22	endothelin 1	Mus musculus	50-62
17913832-0	2007	Role of prostaglandins in collecting duct-derived endothelin-1 regulation of blood pressure and water excretion.	Water	96-101	endothelin 1	Mus musculus	50-62
17913832-2	2007	In vitro studies have implicated cyclooxygenase (COX) metabolites, and particularly PGE(2), as important mediators of CD ET-1 effects.	Dinoprostone	84-90	endothelin 1	Mus musculus	121-125
17913832-5	2007	During normal salt and water intake, urinary PGE(2) excretion was unexpectedly increased in CD ET-1 KO mice compared with controls.	Water	23-28	endothelin 1	Mus musculus	95-99
17913832-5	2007	During normal salt and water intake, urinary PGE(2) excretion was unexpectedly increased in CD ET-1 KO mice compared with controls.	Prostaglandins E	45-48	endothelin 1	Mus musculus	95-99
17913832-14	2007	Furthermore, the increased PGE(2) in CD ET-1 KO mice partly compensates for loss of ET-1 with respect to maintaining urinary water excretion, but not in blood pressure control.	Prostaglandins E	27-30	endothelin 1	Mus musculus	40-44
17885093-5	2007	Systemically administered endothelin-1 (ET-1) triggered an increase in plasma levels of 6-keto prostaglandin F(1alpha) (6-keto PGF(1alpha)) in WT and eNOS-/- but not in iNOS-/- mice.	6-keto prostaglandin f	88-110	endothelin 1	Mus musculus	26-38
17885093-5	2007	Systemically administered endothelin-1 (ET-1) triggered an increase in plasma levels of 6-keto prostaglandin F(1alpha) (6-keto PGF(1alpha)) in WT and eNOS-/- but not in iNOS-/- mice.	6-keto prostaglandin f	88-110	endothelin 1	Mus musculus	40-44
17885093-5	2007	Systemically administered endothelin-1 (ET-1) triggered an increase in plasma levels of 6-keto prostaglandin F(1alpha) (6-keto PGF(1alpha)) in WT and eNOS-/- but not in iNOS-/- mice.	6-keto pgf	120-130	endothelin 1	Mus musculus	26-38
17885093-5	2007	Systemically administered endothelin-1 (ET-1) triggered an increase in plasma levels of 6-keto prostaglandin F(1alpha) (6-keto PGF(1alpha)) in WT and eNOS-/- but not in iNOS-/- mice.	6-keto pgf	120-130	endothelin 1	Mus musculus	40-44
17885093-9	2007	In another series of experiments, ET-1 (0.1 nmol/kg) significantly increased 8-isoprostane plasma levels in WT but not in iNOS-/- mice.	8-epi-prostaglandin F2alpha	77-90	endothelin 1	Mus musculus	34-38
17885093-10	2007	Finally, a 3-week treatment with anti-oxidants inhibited the capacity of ET-1 to significantly increase plasma 6-keto PGF(1alpha) in WT mice.	6-keto pgf	111-121	endothelin 1	Mus musculus	73-77
17885093-11	2007	We show for the first time that iNOS is involved in the control of ET-1-induced prostacyclin release and related inhibition of platelet aggregation in the murine model.	Epoprostenol	80-92	endothelin 1	Mus musculus	67-71
17693463-3	2007	Using available kinetic data, we construct a mathematical model of the IP3 signal production system after stimulation by a hypertrophic alpha-adrenergic agonist (endothelin-1) in the mouse atrial cardiac myocyte.	Inositol 1,4,5-Trisphosphate	71-74	endothelin 1	Mus musculus	162-174
17766485-3	2007	Because similar protocols in mice increase tissue and plasma markers of oxidative stress, we hypothesized that IH-C generation of reactive oxygen species (ROS) contributes to the development of ET-1-dependent hypertension in IH-C rats.	Reactive Oxygen Species	130-153	endothelin 1	Mus musculus	194-198
17825250-4	2007	Y27632, a specific inhibitor of Rho-kinase, significantly suppressed the IL-6 synthesis induced by ET-1 as well as the MYPT-1 phosphorylation.	Y 27632	0-6	endothelin 1	Mus musculus	99-103
17825250-5	2007	Fasudil, another inhibitor of Rho-kinase, reduced the ET-1-stimulated IL-6 synthesis.	fasudil	0-7	endothelin 1	Mus musculus	54-58
17825250-6	2007	Y27632 as well as fasudil attenuated the ET-1-induced phosphorylation of p38 MAP kinase but not p44/p42 MAP kinase.	Y 27632	0-6	endothelin 1	Mus musculus	41-45
17825250-6	2007	Y27632 as well as fasudil attenuated the ET-1-induced phosphorylation of p38 MAP kinase but not p44/p42 MAP kinase.	fasudil	18-25	endothelin 1	Mus musculus	41-45
17766485-3	2007	Because similar protocols in mice increase tissue and plasma markers of oxidative stress, we hypothesized that IH-C generation of reactive oxygen species (ROS) contributes to the development of ET-1-dependent hypertension in IH-C rats.	Reactive Oxygen Species	155-158	endothelin 1	Mus musculus	194-198
17616645-8	2007	In "model" slices in which the [Ca(2+)](i) was constantly maintained at an elevated level by pretreatment of slices with caffeine and ryanodine, the addition of ET increased bronchiole and arteriole contraction.	Caffeine	121-129	endothelin 1	Mus musculus	161-163
17974986-4	2007	In addition, cardiac-specific overexpression of endothelin-1 in mice resulted in a cardiomyopathy resembling the phenotype following doxorubicin administration.	Doxorubicin	133-144	endothelin 1	Mus musculus	48-60
17974986-5	2007	We therefore hypothesized that endothelin-1 is involved in the pathogenesis of doxorubicin cardiotoxicity.	Doxorubicin	79-90	endothelin 1	Mus musculus	31-43
17974986-9	2007	In vitro investigations confirmed the regulation of endothelin-1 by doxorubicin and indicated that the doxorubicin-mediated increase of endothelin-1 expression involves epidermal growth factor receptor signaling via the MEK1/2-ERK1/2 cascade, which was further confirmed by immunoblotting studies in the left ventricle of treated animals.	Doxorubicin	68-79	endothelin 1	Mus musculus	52-64
17974986-9	2007	In vitro investigations confirmed the regulation of endothelin-1 by doxorubicin and indicated that the doxorubicin-mediated increase of endothelin-1 expression involves epidermal growth factor receptor signaling via the MEK1/2-ERK1/2 cascade, which was further confirmed by immunoblotting studies in the left ventricle of treated animals.	Doxorubicin	103-114	endothelin 1	Mus musculus	52-64
17974986-9	2007	In vitro investigations confirmed the regulation of endothelin-1 by doxorubicin and indicated that the doxorubicin-mediated increase of endothelin-1 expression involves epidermal growth factor receptor signaling via the MEK1/2-ERK1/2 cascade, which was further confirmed by immunoblotting studies in the left ventricle of treated animals.	Doxorubicin	103-114	endothelin 1	Mus musculus	136-148
17616645-3	2007	In comparison with acetylcholine (ACh) or serotonin (5-HT), ET induced a stronger and long-lasting contraction of both bronchioles and arterioles.	Serotonin	42-51	endothelin 1	Mus musculus	60-62
17616645-8	2007	In "model" slices in which the [Ca(2+)](i) was constantly maintained at an elevated level by pretreatment of slices with caffeine and ryanodine, the addition of ET increased bronchiole and arteriole contraction.	Ryanodine	134-143	endothelin 1	Mus musculus	161-163
17641672-9	2007	Decreased Ca(2+) transients and cell shortening induced by ET-1 were markedly attenuated by the specific Na(+)/Ca(2+) exchange inhibitor SEA0400.	SEA 0400	137-144	endothelin 1	Mus musculus	59-63
17391658-9	2007	Ang II-induced collagen expression was inhibited by BQ123, suggesting that adventitial ET-1 plays a significant role in regulating the extracellular matrix.	cyclo(Trp-Asp-Pro-Val-Leu)	52-57	endothelin 1	Mus musculus	87-91
17660396-8	2007	In the presence of l-NAME, ET(A) receptor inhibition attenuated ET-1 vasoconstriction in both groups, whereas ET(B) inhibition abolished this response only in control hearts.	NG-Nitroarginine Methyl Ester	19-25	endothelin 1	Mus musculus	64-68
17877911-0	2007	Endothelin-1 inhibits outward potassium currents in mouse outer sulcus cells.	Potassium	30-39	endothelin 1	Mus musculus	0-12
17877911-3	2007	We investigated the electrical properties and the effects of endothelin-1 (ET-1) on the outward potassium currents in mouse outer sulcus cells using a whole-cell patch clamp technique.	Potassium	96-105	endothelin 1	Mus musculus	61-73
17877911-3	2007	We investigated the electrical properties and the effects of endothelin-1 (ET-1) on the outward potassium currents in mouse outer sulcus cells using a whole-cell patch clamp technique.	Potassium	96-105	endothelin 1	Mus musculus	75-79
17877911-7	2007	Application of ET-1 caused a decrease of outward potassium currents within seconds, whereas treatment with BQ123, a competitive inhibitor of the ET type-A receptor, counteracted the inhibitory effect of ET-1.	Potassium	49-58	endothelin 1	Mus musculus	15-19
17877911-7	2007	Application of ET-1 caused a decrease of outward potassium currents within seconds, whereas treatment with BQ123, a competitive inhibitor of the ET type-A receptor, counteracted the inhibitory effect of ET-1.	cyclo(Trp-Asp-Pro-Val-Leu)	107-112	endothelin 1	Mus musculus	203-207
17877911-8	2007	These results suggest that ET-1 inhibits outward potassium currents through the activation of ET type-A receptor.	Potassium	49-58	endothelin 1	Mus musculus	27-31
17669376-3	2007	Bromodeoxyuridine labeling of proliferating cells in the subventricular zone was elevated by about 50% in endothelin-1-treated mice, and cells reactive for doublecortin, a marker for immature neurons, were similarly increased in number.	Bromodeoxyuridine	0-17	endothelin 1	Mus musculus	106-118
17391658-10	2007	NADPH oxidase inhibitors and superoxide scavengers significantly decreased Ang II-induced ET-1 mRNA and peptide expression, superoxide production as well as collagen expression.	Superoxides	29-39	endothelin 1	Mus musculus	90-94
17341678-10	2007	Treatment of mice with bosentan (endothelin-1 receptor antagonist) normalized the coronary perfusion pressure, demonstrating that the elevated endothelin-1 release was sufficient to account for the increased coronary perfusion pressure.	Bosentan	23-31	endothelin 1	Mus musculus	33-45
17952651-5	2007	Moreover, the CB(1), CB(2), and TRVP1 receptors are expressed on microvascular endothelial cells, and their activation by 2-AG counteracts endothelin (ET-1)-induced cerebral microvascular responses (namely, Ca(2+) mobilization and cytoskeleton rearrangement).	cb(1)	14-19	endothelin 1	Mus musculus	139-149
17952651-5	2007	Moreover, the CB(1), CB(2), and TRVP1 receptors are expressed on microvascular endothelial cells, and their activation by 2-AG counteracts endothelin (ET-1)-induced cerebral microvascular responses (namely, Ca(2+) mobilization and cytoskeleton rearrangement).	cb(1)	14-19	endothelin 1	Mus musculus	151-155
17952651-5	2007	Moreover, the CB(1), CB(2), and TRVP1 receptors are expressed on microvascular endothelial cells, and their activation by 2-AG counteracts endothelin (ET-1)-induced cerebral microvascular responses (namely, Ca(2+) mobilization and cytoskeleton rearrangement).	cb(2)	21-26	endothelin 1	Mus musculus	151-155
17952651-5	2007	Moreover, the CB(1), CB(2), and TRVP1 receptors are expressed on microvascular endothelial cells, and their activation by 2-AG counteracts endothelin (ET-1)-induced cerebral microvascular responses (namely, Ca(2+) mobilization and cytoskeleton rearrangement).	glyceryl 2-arachidonate	122-126	endothelin 1	Mus musculus	139-149
17952651-5	2007	Moreover, the CB(1), CB(2), and TRVP1 receptors are expressed on microvascular endothelial cells, and their activation by 2-AG counteracts endothelin (ET-1)-induced cerebral microvascular responses (namely, Ca(2+) mobilization and cytoskeleton rearrangement).	glyceryl 2-arachidonate	122-126	endothelin 1	Mus musculus	151-155
17952651-6	2007	This suggests that the functional interaction between 2-AG and ET-1 may provide a potential alternative pathway for abrogating ET-1-inducible vasoconstriction after brain injury and play a role in the neuroprotective effects exerted by 2-AG, as a potent vasodilator.	glyceryl 2-arachidonate	54-58	endothelin 1	Mus musculus	127-131
17952651-6	2007	This suggests that the functional interaction between 2-AG and ET-1 may provide a potential alternative pathway for abrogating ET-1-inducible vasoconstriction after brain injury and play a role in the neuroprotective effects exerted by 2-AG, as a potent vasodilator.	glyceryl 2-arachidonate	236-240	endothelin 1	Mus musculus	63-67
17952651-6	2007	This suggests that the functional interaction between 2-AG and ET-1 may provide a potential alternative pathway for abrogating ET-1-inducible vasoconstriction after brain injury and play a role in the neuroprotective effects exerted by 2-AG, as a potent vasodilator.	glyceryl 2-arachidonate	236-240	endothelin 1	Mus musculus	127-131
17142347-1	2007	Deoxycorticosterone acetate (DOCA)-salt hypertension has an important endothelin-1 (ET-1)-dependent component.	Desoxycorticosterone Acetate	0-27	endothelin 1	Mus musculus	70-82
17521429-4	2007	RESULTS: CD ET-1 KO IMCD had enhanced AVP-stimulated cAMP accumulation.	Cyclic AMP	53-57	endothelin 1	Mus musculus	12-16
17521429-7	2007	Differential V2 receptor or G-protein activity was not involved since CD ET-1 KO IMCD had increased cAMP accumulation in response to forskolin and/or cholera toxin.	Cyclic AMP	100-104	endothelin 1	Mus musculus	73-77
17521429-7	2007	Differential V2 receptor or G-protein activity was not involved since CD ET-1 KO IMCD had increased cAMP accumulation in response to forskolin and/or cholera toxin.	Colforsin	133-142	endothelin 1	Mus musculus	73-77
17521429-10	2007	CONCLUSION: ET-1 deficiency increases IMCD AC5/6 content, an effect that may synergize with acute ET-1 inhibition of AVP-stimulated cAMP accumulation.	Cyclic AMP	132-136	endothelin 1	Mus musculus	12-16
17521429-10	2007	CONCLUSION: ET-1 deficiency increases IMCD AC5/6 content, an effect that may synergize with acute ET-1 inhibition of AVP-stimulated cAMP accumulation.	Cyclic AMP	132-136	endothelin 1	Mus musculus	98-102
16807013-4	2007	Intra-tumor expression of both ET-1 mRNA and ET-1 protein were significantly upregulated compared to normal tissue, and local administration of the ET-A receptor selective antagonist, BQ-123 (100 microM) significantly elevated withdrawal thresholds, indicating the induction of an antinociceptive effect.	cyclo(Trp-Asp-Pro-Val-Leu)	184-190	endothelin 1	Mus musculus	31-35
17448648-11	2007	), endothelin-1 (100 pmol, intranasally) or the ET(B) receptor agonist IRL-1620 (100 pmol, intranasally) showed a marked increase in airway reactivity to carbachol.	Carbachol	154-163	endothelin 1	Mus musculus	3-15
17350626-0	2007	(-)-Epigallocatechin gallate suppresses endothelin-1-induced interleukin-6 synthesis in osteoblasts: inhibition of p44/p42 MAP kinase activation.	epigallocatechin gallate	0-28	endothelin 1	Mus musculus	40-52
17350626-2	2007	In the present study, we investigated the effect of (-)-epigallocatechin gallate (EGCG), one of the major flavonoids containing in green tea, on ET-1-induced IL-6 synthesis in osteoblasts and the underlying mechanism.	epigallocatechin gallate	52-80	endothelin 1	Mus musculus	145-149
17350626-2	2007	In the present study, we investigated the effect of (-)-epigallocatechin gallate (EGCG), one of the major flavonoids containing in green tea, on ET-1-induced IL-6 synthesis in osteoblasts and the underlying mechanism.	epigallocatechin gallate	82-86	endothelin 1	Mus musculus	145-149
17350626-3	2007	EGCG significantly reduced the synthesis of IL-6 stimulated by ET-1 in MC3T3-E1 cells as well primary cultured mouse osteoblasts.	epigallocatechin gallate	0-4	endothelin 1	Mus musculus	63-67
17350626-4	2007	SB203580, a specific inhibitor of p38 MAP kinase, but not SP600125, a specific SAPK/JNK inhibitor, suppressed ET-1-stimulated IL-6 synthesis.	SB 203580	0-8	endothelin 1	Mus musculus	110-114
17350626-6	2007	On the other hand, EGCG suppressed the phosphorylation of p44/p42 MAP kinase induced by ET-1.	epigallocatechin gallate	19-23	endothelin 1	Mus musculus	88-92
17350626-8	2007	The phosphorylation of MEK1/2 and Raf-1 induced by ET-1 or TPA were also inhibited by EGCG.	epigallocatechin gallate	86-90	endothelin 1	Mus musculus	51-55
17350626-9	2007	These results strongly suggest that EGCG inhibits ET-1-stimulated synthesis of IL-6 via suppression of p44/p42 MAP kinase pathway in osteoblasts, and the inhibitory effect is exerted at a point between PKC and Raf-1 in the ET-1 signaling cascade.	epigallocatechin gallate	36-40	endothelin 1	Mus musculus	50-54
17350626-9	2007	These results strongly suggest that EGCG inhibits ET-1-stimulated synthesis of IL-6 via suppression of p44/p42 MAP kinase pathway in osteoblasts, and the inhibitory effect is exerted at a point between PKC and Raf-1 in the ET-1 signaling cascade.	epigallocatechin gallate	36-40	endothelin 1	Mus musculus	223-227
17194566-8	2007	In addition, significant PGE2 production was detected after IL-18 or ET-1 (via ET(A) receptors) injection in naive mice.	Dinoprostone	25-29	endothelin 1	Mus musculus	69-73
17379641-6	2007	Stimulation of IP3 production by phenylephrine or endothelin-1 had a positive chronotropic effect that could be reversed by U73122 and 2-APB.	Inositol 1,4,5-Trisphosphate	15-18	endothelin 1	Mus musculus	50-62
17379641-6	2007	Stimulation of IP3 production by phenylephrine or endothelin-1 had a positive chronotropic effect that could be reversed by U73122 and 2-APB.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	124-130	endothelin 1	Mus musculus	50-62
17395629-0	2007	Cell-type specific interaction of endothelin and the nitric oxide system: pattern of prepro-ET-1 expression in kidneys of L-NAME treated prepro-ET-1 promoter-lacZ-transgenic mice.	NG-Nitroarginine Methyl Ester	122-128	endothelin 1	Mus musculus	92-96
17395629-0	2007	Cell-type specific interaction of endothelin and the nitric oxide system: pattern of prepro-ET-1 expression in kidneys of L-NAME treated prepro-ET-1 promoter-lacZ-transgenic mice.	NG-Nitroarginine Methyl Ester	122-128	endothelin 1	Mus musculus	144-148
17395629-1	2007	Nitric oxide (NO) and endothelin-1 (ET-1) are known to play a major role in renal and vascular pathophysiology and exhibit a close interaction with ET-1, stimulating NO production; NO in turn inhibits ET-1 expression.	Nitric Oxide	0-12	endothelin 1	Mus musculus	148-152
17395629-1	2007	Nitric oxide (NO) and endothelin-1 (ET-1) are known to play a major role in renal and vascular pathophysiology and exhibit a close interaction with ET-1, stimulating NO production; NO in turn inhibits ET-1 expression.	Nitric Oxide	0-12	endothelin 1	Mus musculus	148-152
17395629-4	2007	Bluo-Gal staining of tissue sections revealed intracellular blue particles as indicators of prepro-ET-1 promoter activity.	5-BROMO-3-INDOLYL-beta-D-GALACTOPYRANOSIDE	0-8	endothelin 1	Mus musculus	99-103
17395629-8	2007	Bluo-Gal staining of kidney sections revealed intracellular blue particles as indicators of prepro-ET-1 promoter activity in tubular and vascular endothelium and glomerular cells.	5-BROMO-3-INDOLYL-beta-D-GALACTOPYRANOSIDE	0-8	endothelin 1	Mus musculus	99-103
17568972-8	2007	Pharmacological investigations led us to demonstrate that the significant difference in [Ca(2+)]( i ) peak amplitude during the ET-1 action was associated with decreased calcium influx involving L-type voltage-sensitive calcium channels, whereas calcium release from intracellular stores and implication of phospholipase C were not affected by the reduced expression of Cx43.	Calcium	170-177	endothelin 1	Mus musculus	128-132
17568972-8	2007	Pharmacological investigations led us to demonstrate that the significant difference in [Ca(2+)]( i ) peak amplitude during the ET-1 action was associated with decreased calcium influx involving L-type voltage-sensitive calcium channels, whereas calcium release from intracellular stores and implication of phospholipase C were not affected by the reduced expression of Cx43.	Calcium	220-227	endothelin 1	Mus musculus	128-132
17521429-1	2007	BACKGROUND: Endothelin-1 (ET-1) inhibition of vasopressin (AVP)-stimulated water reabsorption by the inner medullary collecting duct (IMCD) is associated with reduced cAMP accumulation.	Water	75-80	endothelin 1	Mus musculus	12-24
17521429-1	2007	BACKGROUND: Endothelin-1 (ET-1) inhibition of vasopressin (AVP)-stimulated water reabsorption by the inner medullary collecting duct (IMCD) is associated with reduced cAMP accumulation.	Water	75-80	endothelin 1	Mus musculus	26-30
17521429-1	2007	BACKGROUND: Endothelin-1 (ET-1) inhibition of vasopressin (AVP)-stimulated water reabsorption by the inner medullary collecting duct (IMCD) is associated with reduced cAMP accumulation.	Cyclic AMP	167-171	endothelin 1	Mus musculus	12-24
17521429-1	2007	BACKGROUND: Endothelin-1 (ET-1) inhibition of vasopressin (AVP)-stimulated water reabsorption by the inner medullary collecting duct (IMCD) is associated with reduced cAMP accumulation.	Cyclic AMP	167-171	endothelin 1	Mus musculus	26-30
17351652-8	2007	The ET(A) receptor antagonist BQ123 significantly reduced scratching evoked by ET-1 and IRL 1620, suggesting that both agonists caused scratching via an ET(A) receptor-dependent mechanism.	cyclo(Trp-Asp-Pro-Val-Leu)	30-35	endothelin 1	Mus musculus	79-83
17142347-1	2007	Deoxycorticosterone acetate (DOCA)-salt hypertension has an important endothelin-1 (ET-1)-dependent component.	Desoxycorticosterone Acetate	0-27	endothelin 1	Mus musculus	84-88
17142347-1	2007	Deoxycorticosterone acetate (DOCA)-salt hypertension has an important endothelin-1 (ET-1)-dependent component.	Desoxycorticosterone Acetate	29-33	endothelin 1	Mus musculus	70-82
17142347-1	2007	Deoxycorticosterone acetate (DOCA)-salt hypertension has an important endothelin-1 (ET-1)-dependent component.	Desoxycorticosterone Acetate	29-33	endothelin 1	Mus musculus	84-88
17142347-1	2007	Deoxycorticosterone acetate (DOCA)-salt hypertension has an important endothelin-1 (ET-1)-dependent component.	Salts	35-39	endothelin 1	Mus musculus	70-82
17142347-1	2007	Deoxycorticosterone acetate (DOCA)-salt hypertension has an important endothelin-1 (ET-1)-dependent component.	Salts	35-39	endothelin 1	Mus musculus	84-88
17438402-9	2007	When VSMC caveolae were disrupted in control arteries using the cholesterol acceptor methyl-beta-cyclodextrin, there was a similar impairment in constriction to endothelin-1 or alpha2-AR stimulation, but not alpha1-AR activation.	vsmc	5-9	endothelin 1	Mus musculus	161-173
17438402-9	2007	When VSMC caveolae were disrupted in control arteries using the cholesterol acceptor methyl-beta-cyclodextrin, there was a similar impairment in constriction to endothelin-1 or alpha2-AR stimulation, but not alpha1-AR activation.	Cholesterol	64-75	endothelin 1	Mus musculus	161-173
17438402-9	2007	When VSMC caveolae were disrupted in control arteries using the cholesterol acceptor methyl-beta-cyclodextrin, there was a similar impairment in constriction to endothelin-1 or alpha2-AR stimulation, but not alpha1-AR activation.	methyl-beta-cyclodextrin	85-109	endothelin 1	Mus musculus	161-173
17334537-10	2007	In vitro, pre-incubation with ET-1 (0.1 microM) 4 h before infection enhanced the uptake of the parasites by peritoneal macrophages, and this effect was abrogated when macrophages were pre-treated with bosentan (1 microM) 15 min before incubation with ET-1.	Bosentan	202-210	endothelin 1	Mus musculus	30-34
17334537-10	2007	In vitro, pre-incubation with ET-1 (0.1 microM) 4 h before infection enhanced the uptake of the parasites by peritoneal macrophages, and this effect was abrogated when macrophages were pre-treated with bosentan (1 microM) 15 min before incubation with ET-1.	Bosentan	202-210	endothelin 1	Mus musculus	252-256
17287431-3	2007	It was hypothesized that vascular effects of ET-1 may be antagonized by an increase of the endothelial counterpart of ET-1, nitric oxide (NO), which is produced by the endothelial NO synthase (eNOS).	Nitric Oxide	124-136	endothelin 1	Mus musculus	45-49
17414227-6	2007	In addition, the I/R-induced increase in renal endothelin-1 (ET-1) content was suppressed by preischemic treatment with EIPA, reflecting the difference in immunohistochemical ET-1 localization in necrotic tubular epithelium.	ethylisopropylamiloride	120-124	endothelin 1	Mus musculus	47-59
17414227-6	2007	In addition, the I/R-induced increase in renal endothelin-1 (ET-1) content was suppressed by preischemic treatment with EIPA, reflecting the difference in immunohistochemical ET-1 localization in necrotic tubular epithelium.	ethylisopropylamiloride	120-124	endothelin 1	Mus musculus	61-65
17414227-6	2007	In addition, the I/R-induced increase in renal endothelin-1 (ET-1) content was suppressed by preischemic treatment with EIPA, reflecting the difference in immunohistochemical ET-1 localization in necrotic tubular epithelium.	ethylisopropylamiloride	120-124	endothelin 1	Mus musculus	175-179
17287431-3	2007	It was hypothesized that vascular effects of ET-1 may be antagonized by an increase of the endothelial counterpart of ET-1, nitric oxide (NO), which is produced by the endothelial NO synthase (eNOS).	Nitric Oxide	124-136	endothelin 1	Mus musculus	118-122
17068292-5	2006	In primary cultures of JG cells, calcium-dependent inhibitors of renin release (angiotensin II, endothelin-1, thapsigargin) suppressed renin secretion, which was paralleled by decreases in intracellular cAMP levels [cAMP].	Calcium	33-40	endothelin 1	Mus musculus	96-108
17068292-5	2006	In primary cultures of JG cells, calcium-dependent inhibitors of renin release (angiotensin II, endothelin-1, thapsigargin) suppressed renin secretion, which was paralleled by decreases in intracellular cAMP levels [cAMP].	Cyclic AMP	203-207	endothelin 1	Mus musculus	96-108
17068292-5	2006	In primary cultures of JG cells, calcium-dependent inhibitors of renin release (angiotensin II, endothelin-1, thapsigargin) suppressed renin secretion, which was paralleled by decreases in intracellular cAMP levels [cAMP].	Cyclic AMP	216-220	endothelin 1	Mus musculus	96-108
16925845-3	2006	Folinic acid at concentrations of 1.0 and 0.1 mm significantly increased ET-1 and dHAND protein expression levels compared to retinoic acid-exposed values in embryonic branchial areas.	Leucovorin	0-12	endothelin 1	Mus musculus	73-77
16925845-4	2006	Folinic acid also increased ET-1 and dHAND mRNA levels in the same region.	Leucovorin	0-12	endothelin 1	Mus musculus	28-32
16925845-0	2006	Prevention of retinoic acid-induced early craniofacial abnormalities by folinic acid and expression of endothelin-1/dHAND in the branchial arches in mouse.	Tretinoin	14-27	endothelin 1	Mus musculus	103-115
16925845-5	2006	The present results suggest that folinic acid may prevent retinoic acid-induced craniofacial abnormalities via increasing ET-1 and dHAND levels in the branchial region during the organogenic period.	Leucovorin	33-45	endothelin 1	Mus musculus	122-126
16925845-5	2006	The present results suggest that folinic acid may prevent retinoic acid-induced craniofacial abnormalities via increasing ET-1 and dHAND levels in the branchial region during the organogenic period.	retinoic	58-66	endothelin 1	Mus musculus	122-126
16908774-7	2006	Terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling analysis reveals greater abundance of apoptotic nuclei in the ET-1-deficient hearts.	deoxyuridine triphosphate	47-51	endothelin 1	Mus musculus	132-136
16877529-5	2006	The present study used isolated arteries and VSMCs to investigate the role of the EGFR ligand heparin binding-epidermal growth factor (HB-EGF) in ET-1-induced transactivation of EGFR, intracellular calcium mobilization, and VSMCs contraction.	Calcium	198-205	endothelin 1	Mus musculus	146-150
16877529-10	2006	The ET-1-induced calcium peak was reduced by 30% in VSMCs from wa2 mice and from HB-EGF-/- mice.	Calcium	17-24	endothelin 1	Mus musculus	4-8
16877529-13	2006	Pretreatment of mouse VSMCs with batimastat, a metalloproteinase inhibitor, significantly attenuated ET-1-induced [Ca(2+)](i) response in wild-type cells.	batimastat	33-43	endothelin 1	Mus musculus	101-105
16766656-10	2006	Prostaglandin E(2) (PGE(2)) production was induced by IL-15, IFN-gamma, or ET-1.	Prostaglandins E	20-23	endothelin 1	Mus musculus	75-79
16766656-7	2006	Consistent with this finding, IFN-gamma and ET-1 induced dose- and time-dependent mechanical hypernociception that was inhibited by BQ123 or indomethacin but not BQ788 (an ET(B) receptor antagonist).	cyclo(Trp-Asp-Pro-Val-Leu)	132-137	endothelin 1	Mus musculus	44-48
16870175-5	2006	We found that CpG dinucleotides within a short region in intron 1 of the gene have dramatically higher levels of methylation in Et1-non-expressing fibroblasts and chondrocytes as compared to the Et1-expressing mouse cell line, mIMCD-3.	Dinucleoside Phosphates	18-31	endothelin 1	Mus musculus	128-131
16816106-7	2006	Another class of LPS-inducible genes, which included Ccl2, Ccl7, and Edn1, was suppressed by TSA, an effect most likely mediated by PU.1 degradation.	trichostatin A	93-96	endothelin 1	Mus musculus	69-73
16766656-14	2006	Therefore, our results demonstrate the sequential mechanical hypernociceptive effect of IL-15 --&gt; IFN-gamma --&gt; ET-1 --&gt; PGE(2) and suggest that these molecules may be targets of therapeutic intervention in antigen-induced hypernociception.	Prostaglandins E	130-133	endothelin 1	Mus musculus	118-122
16766656-7	2006	Consistent with this finding, IFN-gamma and ET-1 induced dose- and time-dependent mechanical hypernociception that was inhibited by BQ123 or indomethacin but not BQ788 (an ET(B) receptor antagonist).	Indomethacin	141-153	endothelin 1	Mus musculus	44-48
16741003-1	2006	We have discovered that endothelin-1 (ET-1) vasoconstriction is significantly enhanced in aortas of young (8-16-week-old) apolipoprotein E-deficient (ApoE-/-) mice devoid of atherosclerotic lesions (maximum response expressed as a percentage of the mean response to 100 mM KCl (E(MAX)) = 55.7% +/- 19.5% KCl, n = 5) compared to age-matched C57BL/6/J control animals (E(MAX) = 12.6% +/- 2.5% KCl, n = 8), indicating that alterations in the endothelin system may contribute to disease progression, at least in this animal model.	Potassium Chloride	304-307	endothelin 1	Mus musculus	38-42
16766656-10	2006	Prostaglandin E(2) (PGE(2)) production was induced by IL-15, IFN-gamma, or ET-1.	Dinoprostone	0-18	endothelin 1	Mus musculus	75-79
16740998-6	2006	The maximal contraction to ET-1 was strong and significantly greater in the femoral (105 +/- 7% KCl) and renal artery (62 +/- 7% KCl) than in the carotid artery or the aorta (P &lt; 0.05).	Potassium Chloride	96-99	endothelin 1	Mus musculus	27-31
16740998-6	2006	The maximal contraction to ET-1 was strong and significantly greater in the femoral (105 +/- 7% KCl) and renal artery (62 +/- 7% KCl) than in the carotid artery or the aorta (P &lt; 0.05).	Potassium Chloride	129-132	endothelin 1	Mus musculus	27-31
16741003-1	2006	We have discovered that endothelin-1 (ET-1) vasoconstriction is significantly enhanced in aortas of young (8-16-week-old) apolipoprotein E-deficient (ApoE-/-) mice devoid of atherosclerotic lesions (maximum response expressed as a percentage of the mean response to 100 mM KCl (E(MAX)) = 55.7% +/- 19.5% KCl, n = 5) compared to age-matched C57BL/6/J control animals (E(MAX) = 12.6% +/- 2.5% KCl, n = 8), indicating that alterations in the endothelin system may contribute to disease progression, at least in this animal model.	Potassium Chloride	273-276	endothelin 1	Mus musculus	24-36
16415072-10	2006	The ET-1-induced response in Cav-1(-/-) cells was mediated by the ET(B) receptor, as shown using the ET(B) receptor antagonist BQ-788 and the ET(A) receptor antagonist BQ-123.	bulaquine	127-129	endothelin 1	Mus musculus	4-8
16415076-3	2006	Recombinant full-length adiponectin suppressed the ET-1-induced increase in cell surface area and [(3)H]leucine incorporation into cultured cardiomyocytes compared with cells treated with ET-1 alone.	Leucine	104-111	endothelin 1	Mus musculus	51-55
16415076-6	2006	Transfection of siRNA for alpha(2)-catalytic subunits of AMPK reduced the inhibitory effects of adiponectin on ET-1-induced cellular hypertrophy and ERK1/2 phosphorylation.	alpha(2)	26-34	endothelin 1	Mus musculus	111-115
16741057-8	2006	LU208075 treatment normalized the upregulated expression of ET-1 and adrenomedullin, as well as the deficit in MIFI, but did not affect the increased ETRA and ETRB expression or the elevated plasma glucose levels found in nontreated animals.	ambrisentan	0-8	endothelin 1	Mus musculus	60-83
16741066-4	2006	ET-1 caused dose-dependent scratching bouts, which, like the responses to histamine and compound 48/80, occurred mainly during the first 5 to 10 mins of injection, but fewer episodes were also seen up to 35 mins.	Histamine	74-83	endothelin 1	Mus musculus	0-4
16741003-1	2006	We have discovered that endothelin-1 (ET-1) vasoconstriction is significantly enhanced in aortas of young (8-16-week-old) apolipoprotein E-deficient (ApoE-/-) mice devoid of atherosclerotic lesions (maximum response expressed as a percentage of the mean response to 100 mM KCl (E(MAX)) = 55.7% +/- 19.5% KCl, n = 5) compared to age-matched C57BL/6/J control animals (E(MAX) = 12.6% +/- 2.5% KCl, n = 8), indicating that alterations in the endothelin system may contribute to disease progression, at least in this animal model.	Potassium Chloride	273-276	endothelin 1	Mus musculus	38-42
16741003-1	2006	We have discovered that endothelin-1 (ET-1) vasoconstriction is significantly enhanced in aortas of young (8-16-week-old) apolipoprotein E-deficient (ApoE-/-) mice devoid of atherosclerotic lesions (maximum response expressed as a percentage of the mean response to 100 mM KCl (E(MAX)) = 55.7% +/- 19.5% KCl, n = 5) compared to age-matched C57BL/6/J control animals (E(MAX) = 12.6% +/- 2.5% KCl, n = 8), indicating that alterations in the endothelin system may contribute to disease progression, at least in this animal model.	Potassium Chloride	304-307	endothelin 1	Mus musculus	24-36
16741003-1	2006	We have discovered that endothelin-1 (ET-1) vasoconstriction is significantly enhanced in aortas of young (8-16-week-old) apolipoprotein E-deficient (ApoE-/-) mice devoid of atherosclerotic lesions (maximum response expressed as a percentage of the mean response to 100 mM KCl (E(MAX)) = 55.7% +/- 19.5% KCl, n = 5) compared to age-matched C57BL/6/J control animals (E(MAX) = 12.6% +/- 2.5% KCl, n = 8), indicating that alterations in the endothelin system may contribute to disease progression, at least in this animal model.	Potassium Chloride	304-307	endothelin 1	Mus musculus	24-36
16741003-1	2006	We have discovered that endothelin-1 (ET-1) vasoconstriction is significantly enhanced in aortas of young (8-16-week-old) apolipoprotein E-deficient (ApoE-/-) mice devoid of atherosclerotic lesions (maximum response expressed as a percentage of the mean response to 100 mM KCl (E(MAX)) = 55.7% +/- 19.5% KCl, n = 5) compared to age-matched C57BL/6/J control animals (E(MAX) = 12.6% +/- 2.5% KCl, n = 8), indicating that alterations in the endothelin system may contribute to disease progression, at least in this animal model.	Potassium Chloride	304-307	endothelin 1	Mus musculus	38-42
16741003-8	2006	Therefore, this protective prevention of enhanced ET-1 vasoconstriction in ApoE-/- mice by atorvastatin was independent of its lipid-lowering properties.	Atorvastatin	91-103	endothelin 1	Mus musculus	50-54
16741017-1	2006	Phosphatidylinositol 4,5-bisphosphate (PIP2) is a key down-stream substrate of the endothelin signaling pathway and plays a role in regulating protein function at the membrane-cytoskeletal interface.	Phosphatidylinositol 4,5-Diphosphate	0-37	endothelin 1	Mus musculus	83-93
16741017-1	2006	Phosphatidylinositol 4,5-bisphosphate (PIP2) is a key down-stream substrate of the endothelin signaling pathway and plays a role in regulating protein function at the membrane-cytoskeletal interface.	Phosphatidylinositol 4,5-Diphosphate	39-43	endothelin 1	Mus musculus	83-93
16384872-13	2006	ET-1 stimulated the release of hepatocyte growth factor, VEGF, PGE(2), and IL-6 from gastric myofibroblasts.	Prostaglandins E	63-66	endothelin 1	Mus musculus	0-4
16384872-16	2006	ET-1 also stimulates migration and proliferation of gastric myofibroblasts and enhances the release of growth factors, angiogenic factors, and PGE(2).	Prostaglandins E	143-146	endothelin 1	Mus musculus	0-4
15815585-0	2005	Endothelin-1 overexpression leads to further water accumulation and brain edema after middle cerebral artery occlusion via aquaporin 4 expression in astrocytic end-feet.	Water	45-50	endothelin 1	Mus musculus	0-12
16340664-2	2006	This review discusses recent developments in understanding the role of the medullary endothelin-1 system in regulating renal salt and water excretion and systemic blood pressure.	Salts	125-129	endothelin 1	Mus musculus	85-97
16340664-4	2006	Endothelin-1 in vitro can inhibit sodium or water transport in the collecting duct and thick ascending limb through autocrine pathways.	Sodium	34-40	endothelin 1	Mus musculus	0-12
16340664-4	2006	Endothelin-1 in vitro can inhibit sodium or water transport in the collecting duct and thick ascending limb through autocrine pathways.	Water	44-49	endothelin 1	Mus musculus	0-12
16340664-6	2006	These effects of endothelin-1 are partially mediated by nitric oxide and cyclooxygenase metabolites which are produced by most medullary cells.	Nitric Oxide	56-68	endothelin 1	Mus musculus	17-29
16340664-7	2006	Mice with collecting duct-specific knockout of the endothelin-1 gene have impaired sodium excretion in response to sodium loading and have hypertension which worsens with high salt intake.	Sodium	83-89	endothelin 1	Mus musculus	51-63
16340664-7	2006	Mice with collecting duct-specific knockout of the endothelin-1 gene have impaired sodium excretion in response to sodium loading and have hypertension which worsens with high salt intake.	Sodium	115-121	endothelin 1	Mus musculus	51-63
16340664-7	2006	Mice with collecting duct-specific knockout of the endothelin-1 gene have impaired sodium excretion in response to sodium loading and have hypertension which worsens with high salt intake.	Salts	176-180	endothelin 1	Mus musculus	51-63
16340664-11	2006	SUMMARY: Medullary endothelin-1 regulates renal sodium and water transport and medullary blood flow.	Sodium	48-54	endothelin 1	Mus musculus	19-31
16340664-11	2006	SUMMARY: Medullary endothelin-1 regulates renal sodium and water transport and medullary blood flow.	Water	59-64	endothelin 1	Mus musculus	19-31
16340664-13	2006	Medullary endothelin-1 is fundamentally important in physiologic regulation of renal sodium and water excretion and maintenance of normal systemic blood pressure.	Sodium	85-91	endothelin 1	Mus musculus	10-22
16373854-3	2005	After 3 weeks of CH (10% O2) exposure, we found that the isolated intra-pulmonary artery (PA) constrictor response to ET-1 was significantly increased in wild-type (wt) mice.	Superoxides	25-27	endothelin 1	Mus musculus	118-122
16373854-4	2005	The administration of Cu/Zn superoxide dismutase (SOD) markedly reduced the CH-enhanced maximal PA constrictor response to ET-1, demonstrating the contribution of superoxide to CH-enhanced PA constrictor responses.	Superoxides	28-38	endothelin 1	Mus musculus	123-127
16373854-4	2005	The administration of Cu/Zn superoxide dismutase (SOD) markedly reduced the CH-enhanced maximal PA constrictor response to ET-1, demonstrating the contribution of superoxide to CH-enhanced PA constrictor responses.	Protactinium	96-98	endothelin 1	Mus musculus	123-127
16373854-5	2005	Using mice that are completely deficient in gp91phox (a subunit protein of the superoxide producing nicotinamide adenine dinucleotide phosphate [NADPH] oxidase), we found that CH-enhanced PA constriction to ET-1 was completely blocked (decreases in mean [+/- SE] maximal isometric tension from 5.43 +/- 0.35 to 3.33 +/- 0.19 mN; n = 7; p &lt; 0.01).	NAD	100-133	endothelin 1	Mus musculus	207-211
16373854-5	2005	Using mice that are completely deficient in gp91phox (a subunit protein of the superoxide producing nicotinamide adenine dinucleotide phosphate [NADPH] oxidase), we found that CH-enhanced PA constriction to ET-1 was completely blocked (decreases in mean [+/- SE] maximal isometric tension from 5.43 +/- 0.35 to 3.33 +/- 0.19 mN; n = 7; p &lt; 0.01).	Protactinium	188-190	endothelin 1	Mus musculus	207-211
16373854-7	2005	The addition of ET-1 further increased superoxide production.	Superoxides	39-49	endothelin 1	Mus musculus	16-20
16373854-10	2005	Our results demonstrate that the CH-enhanced PA constrictor response to ET-1 is mediated by NADPH oxidase (gp91phox)-derived superoxide overproduction that may contribute to the pathogenesis of CH-induced PH.	Superoxides	125-135	endothelin 1	Mus musculus	72-76
16107552-2	2005	Genetic deletion of the AhR results in cardiac hypertrophy that is mediated primarily by endothelin-1 (ET-1); ET-1 has been implicated in the elevation of reactive oxygen species (ROS) in the heart, which are thought to contribute to several cardiovascular disorders, including cardiac hypertrophy.	Reactive Oxygen Species	155-178	endothelin 1	Mus musculus	110-114
16107552-2	2005	Genetic deletion of the AhR results in cardiac hypertrophy that is mediated primarily by endothelin-1 (ET-1); ET-1 has been implicated in the elevation of reactive oxygen species (ROS) in the heart, which are thought to contribute to several cardiovascular disorders, including cardiac hypertrophy.	Reactive Oxygen Species	180-183	endothelin 1	Mus musculus	110-114
16107552-3	2005	Thus, we tested the novel hypothesis that ET-1 induces ROS in AhR null mice via ET(A) receptor activation.	Reactive Oxygen Species	55-58	endothelin 1	Mus musculus	42-46
16107552-6	2005	Then, to elucidate whether ET-1 mediated the increase in ROS, mice were chronically treated with 100 ng/kg/day of the ET(A) receptor antagonist BQ-123.	Reactive Oxygen Species	57-60	endothelin 1	Mus musculus	27-31
16107552-6	2005	Then, to elucidate whether ET-1 mediated the increase in ROS, mice were chronically treated with 100 ng/kg/day of the ET(A) receptor antagonist BQ-123.	cyclo(Trp-Asp-Pro-Val-Leu)	144-150	endothelin 1	Mus musculus	27-31
16107552-9	2005	These findings demonstrate that ET-1 activation of ET(A) receptors mediates an increase in ROS that is associated with cardiac hypertrophy in AhR null mice.	Reactive Oxygen Species	91-94	endothelin 1	Mus musculus	32-36
16107552-10	2005	In addition, the ET-1-mediated increase in ROS appears to be initiated via increased NAD(P)H oxidase activity.	Reactive Oxygen Species	43-46	endothelin 1	Mus musculus	17-21
15928212-1	2005	Collecting duct (CD)-specific knockout (KO) of endothelin-1 (ET-1) causes hypertension, impaired ability to excrete a Na load, and enhanced CD sensitivity to the hydrosmotic effects of vasopressin (AVP).	Cadmium	17-19	endothelin 1	Mus musculus	47-59
15928212-1	2005	Collecting duct (CD)-specific knockout (KO) of endothelin-1 (ET-1) causes hypertension, impaired ability to excrete a Na load, and enhanced CD sensitivity to the hydrosmotic effects of vasopressin (AVP).	Cadmium	17-19	endothelin 1	Mus musculus	61-65
16116085-8	2005	This ET-1 effect was blocked by BQ788, a specific inhibitor of the ETB receptor, and by the expression of a carboxyl-terminal peptide of Galpha q but not Galpha i.	BQ 788	32-37	endothelin 1	Mus musculus	5-9
16116085-10	2005	Moreover, the inhibitory effect of ET-1 was suppressed by the c-Jun N-terminal kinase (JNK) inhibitor SP600125 and the expression of the JNK-binding domain of JNK-interacting protein-1, a specific inhibitor of the JNK pathway.	pyrazolanthrone	102-110	endothelin 1	Mus musculus	35-39
16566828-6	2006	TEZ administration prevented the hyperoxia-induced increases in G (13.1 +/- 1.7 vs. 9.6 +/- 0.3 cmH2O/l, p &lt; 0.05) and H (59 +/- 9 vs. 41 +/- 5 cmH2O/l, p &lt; 0.05) and inhibited the lung responses to ET-1.	N-(2,1,3-Benzothiadiazol-5-yl)acetamide	0-3	endothelin 1	Mus musculus	205-209
16298080-0	2006	Endothelin-1 enhances capsaicin-evoked intracellular Ca2+ response via activation of endothelin a receptor in a protein kinase Cepsilon-dependent manner in dorsal root ganglion neurons.	Capsaicin	22-31	endothelin 1	Mus musculus	0-12
16298080-3	2006	The current study investigated the effects of endothelin-1 on the capsaicin-evoked intracellular Ca2+ response of cultured adult mice dorsal root ganglion neurons.	Capsaicin	66-75	endothelin 1	Mus musculus	46-58
16298080-7	2006	Endothelin-1 (10 nM) enhanced an increase in [Ca2+]i by capsaicin (10 nM) from 87.6+/-11.6 nM to 414.8+/-62.3 nM (71 of 156 neurons).	Capsaicin	56-65	endothelin 1	Mus musculus	0-12
16298080-8	2006	The inhibition of endothelin A receptor (BQ-123) significantly suppressed the enhancing effect of endothelin-1.	cyclo(Trp-Asp-Pro-Val-Leu)	41-47	endothelin 1	Mus musculus	98-110
16298080-9	2006	In addition, a nonselective protein kinase C inhibitor (bisindolylmaleimide I) significantly suppressed the enhancing effect of endothelin-1.	bisindolylmaleimide I	56-77	endothelin 1	Mus musculus	128-140
16298080-13	2006	Our results indicate that endothelin-1 enhances the response of dorsal root ganglion neurons to capsaicin in a protein kinase Cepsilon-dependent manner.	Capsaicin	96-105	endothelin 1	Mus musculus	26-38
16267240-9	2005	Neuronal death caused by a "penumbral" model of stroke, using intracortical endothelin-1 microinjection, was attenuated by tBHQ administration to Nrf2(+/+), but not to Nrf2(-/-) mice, confirming the Nrf2-specific action of tBHQ in vivo.	2-tert-butylhydroquinone	123-127	endothelin 1	Mus musculus	76-88
16107552-0	2005	Endothelin-1-mediated increase in reactive oxygen species and NADPH Oxidase activity in hearts of aryl hydrocarbon receptor (AhR) null mice.	Reactive Oxygen Species	34-57	endothelin 1	Mus musculus	0-12
16020630-7	2005	Plasma renin activity and endothelin-1 plasma levels as well as thiobarbituric acid-reactive substance levels in kidneys were significantly lower in WD mice treated with lacidipine than in untreated ones.	lacidipine	170-180	endothelin 1	Mus musculus	26-38
16103083-7	2005	To test the hypothesis that the endothelin axis is important in lung metastasis, lung metastatic bladder carcinoma cells were injected in mice treated with the endothelin receptor-specific antagonist, atrasentan, thereby blocking engagement of the up-regulated ET-1 ligand with its cognate receptor.	Atrasentan	201-211	endothelin 1	Mus musculus	261-265
15815585-9	2005	Our current data suggest that astrocytic ET-1 has deleterious effects on water homeostasis, cerebral edema and BBB integrity, which contribute to more severe ischemic brain injury.	Water	73-78	endothelin 1	Mus musculus	41-45
15933266-0	2005	Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice.	Inositol 1,4,5-Trisphosphate	86-114	endothelin 1	Mus musculus	0-12
15557017-5	2005	In ASM cells isolated from cd38(-/-) mice, the intracellular calcium responses to acetylcholine and endothelin-1 were significantly lower than in controls.	Calcium	61-68	endothelin 1	Mus musculus	100-112
15855633-6	2005	Both Y27632, which inhibits Rho kinase-dependent stress fiber formation, and jasplakinolide, an F-actin stabilizer, decreased NF-kappaB and Ap-1 activity and reduced ET-1 expression.	Y 27632	5-11	endothelin 1	Mus musculus	166-170
15855633-6	2005	Both Y27632, which inhibits Rho kinase-dependent stress fiber formation, and jasplakinolide, an F-actin stabilizer, decreased NF-kappaB and Ap-1 activity and reduced ET-1 expression.	jasplakinolide	77-91	endothelin 1	Mus musculus	166-170
15834283-13	2005	Contractions to endothelin-1 were not significantly influenced by preincubation with the ETB receptor antagonist BQ-788, but were completely blunted by preincubation with the ETA receptor antagonist BQ-123 in all animals.	cyclo(Trp-Asp-Pro-Val-Leu)	199-205	endothelin 1	Mus musculus	16-28
15975530-7	2005	BQ-610 partially inhibited responses to ET-1 in mesenteric veins from DOCA-salt and SHAM mice while BQ-788 did not affect responses to ET-1.	BQ 610	0-6	endothelin 1	Mus musculus	40-44
15975530-7	2005	BQ-610 partially inhibited responses to ET-1 in mesenteric veins from DOCA-salt and SHAM mice while BQ-788 did not affect responses to ET-1.	doca-salt	70-79	endothelin 1	Mus musculus	40-44
15975530-9	2005	Responses to ET-1 in mesenteric arteries were completely inhibited by BQ-610 while BQ-788 did not affect arterial responses.	BQ 610	70-76	endothelin 1	Mus musculus	13-17
15632412-1	2005	In vitro studies suggest that endothelin-1 (ET-1) inhibits vasopressin (AVP)-stimulated water permeability in the collecting duct (CD).	Water	88-93	endothelin 1	Mus musculus	30-42
15632412-1	2005	In vitro studies suggest that endothelin-1 (ET-1) inhibits vasopressin (AVP)-stimulated water permeability in the collecting duct (CD).	Water	88-93	endothelin 1	Mus musculus	44-48
15632412-6	2005	CD suspensions from CD ET-1 KO mice had enhanced AVP- and forskolin-stimulated cAMP accumulation.	Cadmium	0-2	endothelin 1	Mus musculus	23-27
15632412-6	2005	CD suspensions from CD ET-1 KO mice had enhanced AVP- and forskolin-stimulated cAMP accumulation.	Colforsin	58-67	endothelin 1	Mus musculus	23-27
15632412-6	2005	CD suspensions from CD ET-1 KO mice had enhanced AVP- and forskolin-stimulated cAMP accumulation.	Cyclic AMP	79-83	endothelin 1	Mus musculus	23-27
15632412-7	2005	These data indicate that CD ET-1 KO increases renal sensitivity to the urinary concentrating effects of AVP and suggest that ET-1 functions as a physiological autocrine regulator of AVP action in the CD.	Cadmium	25-27	endothelin 1	Mus musculus	28-32
15557017-6	2005	Pretreatment of ASM cells with a cADPR antagonist resulted in attenuated intracellular calcium responses to endothelin-1 in cells isolated from wild-type mice, but not in those isolated from the cd38(-/-) mice.	Calcium	87-94	endothelin 1	Mus musculus	108-120
15838332-3	2004	Endothelin-1 produced a potent vasoconstriction [EC50: 0.49 nM (0.18-1.3 nM), n = 5], and the maximum response was 11 +/- 2.9% KCl response.	Potassium Chloride	127-130	endothelin 1	Mus musculus	0-12
15647116-7	2005	Six hours I/R (1 hour bilateral hindlimb ischemia and 6 hours of reperfusion) and the continuous infusion of endothelin-1 (ET-1) further aggravated the hypoxia in HbsO2.	hbso2	163-168	endothelin 1	Mus musculus	109-121
15647116-7	2005	Six hours I/R (1 hour bilateral hindlimb ischemia and 6 hours of reperfusion) and the continuous infusion of endothelin-1 (ET-1) further aggravated the hypoxia in HbsO2.	hbso2	163-168	endothelin 1	Mus musculus	123-127
15647116-10	2005	Animals after 6.0 h I/R and continuous infusion of ET-1 revealed higher NAD(P)H autofluorescence compared with 3.0 h I/R animals.	nad(p)h	72-79	endothelin 1	Mus musculus	51-55
15854389-10	2005	CONCLUSION: CIH enhances the expression of HIF-1alpha and its target gene products VEGF and ET-1, and therefore affects the cardiovascular system.	cih	12-15	endothelin 1	Mus musculus	92-96
15838304-4	2004	TET mouse lines were further characterized for ET-1 over-expression in the brain.	tetramethylenedisulfotetramine	0-3	endothelin 1	Mus musculus	47-51
15838304-7	2004	In situ hybridization and immunocytochemical analyses showed that the increased ET-1 mRNA and peptide expressions were detected in endothelial cells of cerebral vessels of TET mice.	tetramethylenedisulfotetramine	172-175	endothelin 1	Mus musculus	80-84
15838304-9	2004	However, after transient middle cerebral artery occlusion, TET mice showed a more severe neurological deficit, and larger infarct size and volume, suggesting that over-expressing ET-1 in endothelial cells is deleterious to neuronal survival under ischemic conditions.	tetramethylenedisulfotetramine	59-62	endothelin 1	Mus musculus	179-183
15838304-10	2004	Our present TET model will serve as an ideal model for studying the role of endothelial ET- 1 in the pathogenesis of ischemic stroke.	tetramethylenedisulfotetramine	12-15	endothelin 1	Mus musculus	88-93
15838261-8	2004	Guanosine triphosphate binding was stimulated by morphine and endothelin-1 in non-tolerant mice and not in morphine-tolerant mice; however, guanosine triphosphate binding was stimulated by BQ123 in morphine-tolerant mice and was unaffected in non-tolerant mice.	Guanosine Triphosphate	0-22	endothelin 1	Mus musculus	62-74
15838353-0	2004	Inhibitory effects of a selective endothelin-A receptor antagonist YM598 on endothelin-1-induced potentiation of nociception in formalin-induced and prostate cancer-induced pain models in mice.	Formaldehyde	128-136	endothelin 1	Mus musculus	76-88
15838353-2	2004	In the present study, we investigated the effects of a selective endothelin-A receptor antagonist, YM598, on the nociception potentiated by ET-1 in formalin-induced and cancer inoculation-induced pain models in mice.	N-(6-methoxy-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl)-2-phenylethenesulfonamide	99-104	endothelin 1	Mus musculus	140-144
15838353-5	2004	ET-1 (10 pmol/paw) potentiated these responses, and single oral administration of YM598 (0.3-3 mg/kg) significantly inhibited this ET-1-induced potentiation of nociception and paw edema.	N-(6-methoxy-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl)-2-phenylethenesulfonamide	82-87	endothelin 1	Mus musculus	131-135
15838353-0	2004	Inhibitory effects of a selective endothelin-A receptor antagonist YM598 on endothelin-1-induced potentiation of nociception in formalin-induced and prostate cancer-induced pain models in mice.	N-(6-methoxy-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl)-2-phenylethenesulfonamide	67-72	endothelin 1	Mus musculus	76-88
15838353-7	2004	Both YM598 and atrasentan (0.3-3 mg/kg) significantly inhibited the ET-1-induced potentiation of nociception.	N-(6-methoxy-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl)-2-phenylethenesulfonamide	5-10	endothelin 1	Mus musculus	68-72
15838353-7	2004	Both YM598 and atrasentan (0.3-3 mg/kg) significantly inhibited the ET-1-induced potentiation of nociception.	Atrasentan	15-25	endothelin 1	Mus musculus	68-72
15327783-4	2004	ETAR blockade by BQ123 in mouse embryo culture has revealed that ET-1/ETAR signaling is critical for dHAND and Dlx6 expression in the mandibular arch mesenchyme around embryonic day (E)8.75-E9.0 and becomes dispensable by E9.5.	cyclo(Trp-Asp-Pro-Val-Leu)	17-22	endothelin 1	Mus musculus	65-69
15083534-9	2004	Furthermore, the ET-1- and ET-3-induced inhibition of K(+) current and migration was abrogated by diclofenac.	Diclofenac	98-108	endothelin 1	Mus musculus	17-21
15072961-4	2004	Results showed that in the abdominal aorta ET-1 induced a concentration-dependent contraction (EC(50): 1.4 nM) with maximum reaching 89.5 +/- 4.9% (10 nM) of that induced by 60 mM K(+) [with nitric oxide synthase (NOS) inhibitor N(omega)-nitro-l-arginine methyl ester (l-NAME)].	NG-Nitroarginine Methyl Ester	229-267	endothelin 1	Mus musculus	43-47
15072961-4	2004	Results showed that in the abdominal aorta ET-1 induced a concentration-dependent contraction (EC(50): 1.4 nM) with maximum reaching 89.5 +/- 4.9% (10 nM) of that induced by 60 mM K(+) [with nitric oxide synthase (NOS) inhibitor N(omega)-nitro-l-arginine methyl ester (l-NAME)].	NG-Nitroarginine Methyl Ester	269-275	endothelin 1	Mus musculus	43-47
15072961-8	2004	Meanwhile, the ET(A) antagonist BQ-123 (1 microM) completely inhibited the maximum ET-1 (10 nM) contractile response.	et(a)	15-20	endothelin 1	Mus musculus	83-87
15072961-8	2004	Meanwhile, the ET(A) antagonist BQ-123 (1 microM) completely inhibited the maximum ET-1 (10 nM) contractile response.	cyclo(Trp-Asp-Pro-Val-Leu)	32-38	endothelin 1	Mus musculus	83-87
15072961-9	2004	Furthermore, we found that in the abdominal aorta that had not been treated with l-NAME, ET-1-induced contraction significantly decreased.	NG-Nitroarginine Methyl Ester	81-87	endothelin 1	Mus musculus	89-93
15314687-0	2004	Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention.	Sodium	74-80	endothelin 1	Mus musculus	37-49
15314687-1	2004	In vitro studies suggest that collecting duct-derived (CD-derived) endothelin-1 (ET-1) can regulate renal Na reabsorption; however, the physiologic role of CD-derived ET-1 is unknown.	Cadmium	55-57	endothelin 1	Mus musculus	67-79
15314687-1	2004	In vitro studies suggest that collecting duct-derived (CD-derived) endothelin-1 (ET-1) can regulate renal Na reabsorption; however, the physiologic role of CD-derived ET-1 is unknown.	Cadmium	55-57	endothelin 1	Mus musculus	81-85
15314687-1	2004	In vitro studies suggest that collecting duct-derived (CD-derived) endothelin-1 (ET-1) can regulate renal Na reabsorption; however, the physiologic role of CD-derived ET-1 is unknown.	Cadmium	156-158	endothelin 1	Mus musculus	167-171
15314687-7	2004	Amiloride or furosemide reduced BP in CD ET-1 KO mice on a normal or high-Na diet and prevented excessive Na retention in salt-loaded CD ET-1 KO mice.	Amiloride	0-9	endothelin 1	Mus musculus	41-45
15314687-7	2004	Amiloride or furosemide reduced BP in CD ET-1 KO mice on a normal or high-Na diet and prevented excessive Na retention in salt-loaded CD ET-1 KO mice.	Amiloride	0-9	endothelin 1	Mus musculus	137-141
15314687-7	2004	Amiloride or furosemide reduced BP in CD ET-1 KO mice on a normal or high-Na diet and prevented excessive Na retention in salt-loaded CD ET-1 KO mice.	Furosemide	13-23	endothelin 1	Mus musculus	41-45
15314687-7	2004	Amiloride or furosemide reduced BP in CD ET-1 KO mice on a normal or high-Na diet and prevented excessive Na retention in salt-loaded CD ET-1 KO mice.	Furosemide	13-23	endothelin 1	Mus musculus	137-141
15314687-7	2004	Amiloride or furosemide reduced BP in CD ET-1 KO mice on a normal or high-Na diet and prevented excessive Na retention in salt-loaded CD ET-1 KO mice.	Benzo(a)pyrene	32-34	endothelin 1	Mus musculus	41-45
15314687-7	2004	Amiloride or furosemide reduced BP in CD ET-1 KO mice on a normal or high-Na diet and prevented excessive Na retention in salt-loaded CD ET-1 KO mice.	Salts	122-126	endothelin 1	Mus musculus	137-141
15314687-8	2004	These studies indicate that CD-derived ET-1 is an important physiologic regulator of renal Na excretion and systemic BP.	Cadmium	28-30	endothelin 1	Mus musculus	39-43
15314687-8	2004	These studies indicate that CD-derived ET-1 is an important physiologic regulator of renal Na excretion and systemic BP.	Benzo(a)pyrene	117-119	endothelin 1	Mus musculus	39-43
15083534-10	2004	In the presence of diclofenac, ET-1 only reduced the K(+) current amplitude by 10.6 +/- 1.1%, and slowed B-16 cell migration by only 10.8 +/- 8.9%.	Diclofenac	19-29	endothelin 1	Mus musculus	31-35
15067320-6	2004	NGF expression, cardiac sympathetic innervation, and norepinephrine concentration were specifically reduced in endothelin-1-deficient mouse hearts, but not in angiotensinogen-deficient mice.	Norepinephrine	53-67	endothelin 1	Mus musculus	111-123
15273750-0	2004	Effect of cholinergic and adrenergic receptor blockade on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis in awake mice.	Nitric Oxide	119-131	endothelin 1	Mus musculus	85-97
14764893-5	2004	We used the alpha-myosin heavy chain promoter to drive expression of Cre and were able to obtain 75% reduction in ET-1 mRNA in cardiac myocytes isolated from these mice at baseline and after stimulation, in vivo, for 24 h with tri-iodothyronine (T3).	Triiodothyronine	227-244	endothelin 1	Mus musculus	114-118
14764893-5	2004	We used the alpha-myosin heavy chain promoter to drive expression of Cre and were able to obtain 75% reduction in ET-1 mRNA in cardiac myocytes isolated from these mice at baseline and after stimulation, in vivo, for 24 h with tri-iodothyronine (T3).	Triiodothyronine	246-248	endothelin 1	Mus musculus	114-118
15273750-2	2004	Atropine reduced, while hexamethonium completely abolished the arrhythmogenic effect of endothelin-1 during nitric oxide synthase inhibition.	Hexamethonium	24-37	endothelin 1	Mus musculus	88-100
14718401-5	2004	Myocardial ET-1 peptide levels were significantly increased in binary transgenic (BT, ET+/tTA+) compared with nonbinary transgenic (NBT, ET+/tTA-; ET-/tTA+; ET-/tTA-) or DOX-treated BT littermates (40.1+/-4.7 versus 2.6+/-1.2 fmol/mL, P&lt;0.003).	Nitroblue Tetrazolium	132-135	endothelin 1	Mus musculus	11-15
14718401-5	2004	Myocardial ET-1 peptide levels were significantly increased in binary transgenic (BT, ET+/tTA+) compared with nonbinary transgenic (NBT, ET+/tTA-; ET-/tTA+; ET-/tTA-) or DOX-treated BT littermates (40.1+/-4.7 versus 2.6+/-1.2 fmol/mL, P&lt;0.003).	tta	90-93	endothelin 1	Mus musculus	11-15
14718401-5	2004	Myocardial ET-1 peptide levels were significantly increased in binary transgenic (BT, ET+/tTA+) compared with nonbinary transgenic (NBT, ET+/tTA-; ET-/tTA+; ET-/tTA-) or DOX-treated BT littermates (40.1+/-4.7 versus 2.6+/-1.2 fmol/mL, P&lt;0.003).	tta	141-144	endothelin 1	Mus musculus	11-15
14718401-5	2004	Myocardial ET-1 peptide levels were significantly increased in binary transgenic (BT, ET+/tTA+) compared with nonbinary transgenic (NBT, ET+/tTA-; ET-/tTA+; ET-/tTA-) or DOX-treated BT littermates (40.1+/-4.7 versus 2.6+/-1.2 fmol/mL, P&lt;0.003).	tta	141-144	endothelin 1	Mus musculus	11-15
14718401-5	2004	Myocardial ET-1 peptide levels were significantly increased in binary transgenic (BT, ET+/tTA+) compared with nonbinary transgenic (NBT, ET+/tTA-; ET-/tTA+; ET-/tTA-) or DOX-treated BT littermates (40.1+/-4.7 versus 2.6+/-1.2 fmol/mL, P&lt;0.003).	Doxycycline	170-173	endothelin 1	Mus musculus	11-15
14718401-5	2004	Myocardial ET-1 peptide levels were significantly increased in binary transgenic (BT, ET+/tTA+) compared with nonbinary transgenic (NBT, ET+/tTA-; ET-/tTA+; ET-/tTA-) or DOX-treated BT littermates (40.1+/-4.7 versus 2.6+/-1.2 fmol/mL, P&lt;0.003).	benzothiazole	82-84	endothelin 1	Mus musculus	11-15
12947345-1	2003	BACKGROUND: We have previously shown that endothelial injury by cyclosporin A (CyA) is associated with an increased endothelin-1 (ET-1) release.	Cyclosporine	64-77	endothelin 1	Mus musculus	116-128
15106802-6	2004	bolus injection of N(omega)-nitro-L-arginine methyl ester (L-NAME) resulted in a significantly higher blood pressure increase in ET-1 transgenic mice, as compared to non-transgenic littermates.	NG-Nitroarginine Methyl Ester	19-57	endothelin 1	Mus musculus	129-133
15106802-6	2004	bolus injection of N(omega)-nitro-L-arginine methyl ester (L-NAME) resulted in a significantly higher blood pressure increase in ET-1 transgenic mice, as compared to non-transgenic littermates.	NG-Nitroarginine Methyl Ester	59-65	endothelin 1	Mus musculus	129-133
15106802-9	2004	Pretreatment with dexamethasone abolished the higher blood pressure increase after L-NAME in ET-1 transgenic mice.	Dexamethasone	18-31	endothelin 1	Mus musculus	93-97
15106802-9	2004	Pretreatment with dexamethasone abolished the higher blood pressure increase after L-NAME in ET-1 transgenic mice.	NG-Nitroarginine Methyl Ester	83-89	endothelin 1	Mus musculus	93-97
12970111-2	2003	Adenosine is known to protect the heart from excessive catecholamine exposure, reduce production of endothelin-1, and attenuate the activation of the renin-angiotensin system.	Adenosine	0-9	endothelin 1	Mus musculus	100-112
12951660-0	2003	Endothelin-1 increases 2-arachidonoyl glycerol (2-AG) production in astrocytes.	glyceryl 2-arachidonate	23-46	endothelin 1	Mus musculus	0-12
12951660-0	2003	Endothelin-1 increases 2-arachidonoyl glycerol (2-AG) production in astrocytes.	glyceryl 2-arachidonate	48-52	endothelin 1	Mus musculus	0-12
12951660-2	2003	Recent studies indicate that endothelin-1, a neuropeptide upregulated during brain injury, increases levels of the endocannabinoid anandamide, a lipid with neuroprotective properties, in astrocytes in primary cultures.	Endocannabinoids	115-130	endothelin 1	Mus musculus	29-41
12951660-2	2003	Recent studies indicate that endothelin-1, a neuropeptide upregulated during brain injury, increases levels of the endocannabinoid anandamide, a lipid with neuroprotective properties, in astrocytes in primary cultures.	anandamide	131-141	endothelin 1	Mus musculus	29-41
12951660-6	2003	We also demonstrate that endothelin-1 increases 2-AG production by 5-fold in these cells, a response that requires extracellular calcium and endothelin-1(A) receptor engagement.	Calcium	129-136	endothelin 1	Mus musculus	25-37
12943527-5	2003	RESULTS: SP600125, a specific inhibitor of SAPK/JNK, markedly reduced ET-1-stimulated HSP27 accumulation.	pyrazolanthrone	9-17	endothelin 1	Mus musculus	70-74
12943527-7	2003	SP600125 reduced the ET-1-increased level of HSP27 mRNA.	pyrazolanthrone	0-8	endothelin 1	Mus musculus	21-25
12943527-8	2003	Calphostin C and Go 6976, inhibitors of protein kinase C, reduced the ET-1-induced phosphorylation of SAPK/JNK.	calphostin C	0-12	endothelin 1	Mus musculus	70-74
12943527-8	2003	Calphostin C and Go 6976, inhibitors of protein kinase C, reduced the ET-1-induced phosphorylation of SAPK/JNK.	Go 6976	17-24	endothelin 1	Mus musculus	70-74
12943527-10	2003	A combination of SP600125 and p38 MAP kinase inhibitor such as SB203580 and PD169316 additively reduced the ET-1-stimulated accumulation of HSP27.	pyrazolanthrone	17-25	endothelin 1	Mus musculus	108-112
12943527-10	2003	A combination of SP600125 and p38 MAP kinase inhibitor such as SB203580 and PD169316 additively reduced the ET-1-stimulated accumulation of HSP27.	SB 203580	63-71	endothelin 1	Mus musculus	108-112
12943527-10	2003	A combination of SP600125 and p38 MAP kinase inhibitor such as SB203580 and PD169316 additively reduced the ET-1-stimulated accumulation of HSP27.	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole	76-84	endothelin 1	Mus musculus	108-112
12950721-10	2003	Pretreatment with pertussis toxin (PTX) or perfusion of cells with the protein kinase C (PKC) inhibitor H-7 abolished the inhibitory effect of ET-1 on the K+ current.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	104-107	endothelin 1	Mus musculus	143-147
12947345-1	2003	BACKGROUND: We have previously shown that endothelial injury by cyclosporin A (CyA) is associated with an increased endothelin-1 (ET-1) release.	Cyclosporine	64-77	endothelin 1	Mus musculus	130-134
12947345-1	2003	BACKGROUND: We have previously shown that endothelial injury by cyclosporin A (CyA) is associated with an increased endothelin-1 (ET-1) release.	Cyclosporine	79-82	endothelin 1	Mus musculus	116-128
12947345-1	2003	BACKGROUND: We have previously shown that endothelial injury by cyclosporin A (CyA) is associated with an increased endothelin-1 (ET-1) release.	Cyclosporine	79-82	endothelin 1	Mus musculus	130-134
12947345-2	2003	We now sought to determine, in an animal model of angiogenesis, if inhibiting the effect of ET-1 on endothelial cells (ECs) would reverse the CyA-mediated endothelial injury in an animal model of angiogenesis.	Cyclosporine	142-145	endothelin 1	Mus musculus	92-96
12871754-1	2003	In neonatal mouse right ventricles, endothelin-1 (ET-1, 1-300 nM) induced a dose-dependent increase in twitch contractions and the dose-response curve was shifted to the right by BQ-123 (10 microM), an endothelin ET(A) receptor antagonist.	cyclo(Trp-Asp-Pro-Val-Leu)	179-185	endothelin 1	Mus musculus	36-48
12871754-1	2003	In neonatal mouse right ventricles, endothelin-1 (ET-1, 1-300 nM) induced a dose-dependent increase in twitch contractions and the dose-response curve was shifted to the right by BQ-123 (10 microM), an endothelin ET(A) receptor antagonist.	cyclo(Trp-Asp-Pro-Val-Leu)	179-185	endothelin 1	Mus musculus	50-54
12871754-5	2003	KB-R7943 (30 microM) almost completely suppressed the positive inotropic effect of ET-1.	2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate	0-8	endothelin 1	Mus musculus	83-87
12895429-5	2003	ET-1 produced dose-dependent contraction of aorta from eNOS+/+ mice that was increased twofold following acute inhibition of all NOS isoforms with N(G)-nitro-L-arginine (L-NNA).	Nitroarginine	147-168	endothelin 1	Mus musculus	0-4
12839867-9	2003	ET-1, but not ET-3, inhibited the TNFalpha-induced expression of iNOS protein and mRNA as well as nitrite production.	Nitrites	98-105	endothelin 1	Mus musculus	0-4
12839867-13	2003	The inhibitory effect of ET-1 was not affected by bisindolylmaleimide, SB 203580 or indomethacin, inhibitors of protein kinase C, p38-MAP kinase and cyclooxygenase, respectively, and was not associated with cAMP production.	bisindolylmaleimide	50-69	endothelin 1	Mus musculus	25-29
12839867-13	2003	The inhibitory effect of ET-1 was not affected by bisindolylmaleimide, SB 203580 or indomethacin, inhibitors of protein kinase C, p38-MAP kinase and cyclooxygenase, respectively, and was not associated with cAMP production.	Cyclic AMP	207-211	endothelin 1	Mus musculus	25-29
12839867-14	2003	However, the effect of ET-1 was partially reversed by wortmannin, suggesting the involvement of PI3 kinase in the transduction signal of ET-1.	Wortmannin	54-64	endothelin 1	Mus musculus	137-141
12895429-5	2003	ET-1 produced dose-dependent contraction of aorta from eNOS+/+ mice that was increased twofold following acute inhibition of all NOS isoforms with N(G)-nitro-L-arginine (L-NNA).	Nitroarginine	170-175	endothelin 1	Mus musculus	0-4
12750265-7	2003	In ovarian carcinoma xenografts, in which the ET-1/ET(A)R autocrine pathway is overexpressed, tumor growth was significantly inhibited in ABT-627-treated mice compared with control.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	138-141	endothelin 1	Mus musculus	46-50
12490547-6	2003	Compared with their wild-type littermates, aortic rings of Epo transgenic animals exhibited a marked reduction in vascular reactivity to ET-1 and big ET-1, but this effect was abrogated upon preincubation with the NO synthase inhibitor N-nitro-L-arginine methyl ester (L-NAME).	n-nitro-l-arginine methyl ester	236-267	endothelin 1	Mus musculus	137-141
12910311-0	2003	Arrhythmogenic effects of endothelin-1 under conditions of NO-synthase blockade with L-NAME in NMRI mice.	NG-Nitroarginine Methyl Ester	85-91	endothelin 1	Mus musculus	26-38
12571099-4	2003	Endothelin-1 (ET-1) signaling regulates the branchial arch enhancer and is required for dHAND expression in the branchial arches.	dhand	88-93	endothelin 1	Mus musculus	0-12
12571099-4	2003	Endothelin-1 (ET-1) signaling regulates the branchial arch enhancer and is required for dHAND expression in the branchial arches.	dhand	88-93	endothelin 1	Mus musculus	14-18
12584267-0	2003	Increase in nitric oxide bioavailability improves endothelial function in endothelin-1 transgenic mice.	Nitric Oxide	12-24	endothelin 1	Mus musculus	74-86
12584267-3	2003	We thus hypothesized that vascular ET-1 effects may be antagonized by increased activity of other regulatory systems, such as the increase in bioavailability of the endothelial counterpart of ET-1, nitric oxide (NO).	Nitric Oxide	198-210	endothelin 1	Mus musculus	35-39
12584267-6	2003	RESULTS: Maximum endothelium-dependent relaxation was enhanced in ET-1 transgenic mice (93+/-3% vs 84+/-4% for wild-type littermates; P&lt;0.05) and was inhibited by preincubation with L-NAME in both ET-transgenic mice and wild-type littermates (11+/-5% vs 9+/-4% maximum relaxation, respectively).	NG-Nitroarginine Methyl Ester	185-191	endothelin 1	Mus musculus	66-70
12584267-10	2003	Correspondingly, urinary nitrate/nitrite excretion was significantly elevated in ET-1 transgenic mice.	Nitrates	25-32	endothelin 1	Mus musculus	81-85
12584267-10	2003	Correspondingly, urinary nitrate/nitrite excretion was significantly elevated in ET-1 transgenic mice.	Nitrites	33-40	endothelin 1	Mus musculus	81-85
12490547-6	2003	Compared with their wild-type littermates, aortic rings of Epo transgenic animals exhibited a marked reduction in vascular reactivity to ET-1 and big ET-1, but this effect was abrogated upon preincubation with the NO synthase inhibitor N-nitro-L-arginine methyl ester (L-NAME).	n-nitro-l-arginine methyl ester	236-267	endothelin 1	Mus musculus	150-154
12473537-7	2003	We found that enalapril administration ameliorated the increased expression of ET-1 mRNA in the obstructed kidney by 44% (P &lt; 0.02).	Enalapril	14-23	endothelin 1	Mus musculus	79-83
12616338-6	2003	in the injected paw, both effects being inhibited by the coadministration of ET-1 with endothelin type A (ET(A)) receptor antagonist, BQ-123 (0.3-10 nmol), but not with endothelin type B (ET(B)) receptor antagonist, BQ-788 (10 nmol).	cyclo(Trp-Asp-Pro-Val-Leu)	134-140	endothelin 1	Mus musculus	77-81
12616338-6	2003	in the injected paw, both effects being inhibited by the coadministration of ET-1 with endothelin type A (ET(A)) receptor antagonist, BQ-123 (0.3-10 nmol), but not with endothelin type B (ET(B)) receptor antagonist, BQ-788 (10 nmol).	BQ 788	216-222	endothelin 1	Mus musculus	77-81
12616338-7	2003	Moreover, the licking behavior induced by ET-1 was dose-dependently inhibited by the prototypical micro -opioid agonist, morphine.	Morphine	121-129	endothelin 1	Mus musculus	42-46
12616338-10	2003	This effect is inhibited by BQ-123 (10 nmol) but not by BQ-788 (10 nmol).Thus, local ET-1 induces nocifensive behavior and thermal hyperalgesia acting through ET(A) receptors.	cyclo(Trp-Asp-Pro-Val-Leu)	28-34	endothelin 1	Mus musculus	85-89
12409963-6	2002	Similarly, contractions to endothelin-1 were largely blocked by meclofenamate and were increased in the aorta of obese mice.	Meclofenamic Acid	64-77	endothelin 1	Mus musculus	27-39
12388321-0	2002	Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells.	Calcium	23-30	endothelin 1	Mus musculus	0-12
12388321-4	2002	ET-1 caused an increase in As4.1 cell intracelluar Ca(2+) concentration ([Ca(2+)](i)) mediated by the ET(A) receptor as its antagonist, BQ-123, abolished the response.	cyclo(Trp-Asp-Pro-Val-Leu)	136-142	endothelin 1	Mus musculus	0-4
12388321-7	2002	ET-1 dose dependently increased total inositol phosphates with an EC(50) of 2.1 nM.	Inositol Phosphates	38-57	endothelin 1	Mus musculus	0-4
12193121-6	2002	The ECE inhibitor CGS35066 (10 microM) inhibited contractions induced by big ET-1 (4.8-fold rightward shift of dose-response curve; P&lt;0.05), but not those induced by either ET-1(1-21) or ET-1(1-31).	CGS 35066	18-26	endothelin 1	Mus musculus	77-81
12193136-5	2002	Forskolin, a potent stimulator which stimulates adenylate cyclase and increases the intracellular cAMP level, partially inhibited insulin-stimulated glucose uptake in 3T3-L1 cells, but had no significant impact on the effect of ET-1.	Colforsin	0-9	endothelin 1	Mus musculus	228-232
12372435-4	2002	ET-1 gene expression increases significantly, parallel to the increase in beta-casein gene expression, in epithelial cell lines (HC11) of mouse mammary gland after hormonal stimulation by addition of dexamethazone and prolactin.	Dexamethasone	200-213	endothelin 1	Mus musculus	0-4
12193121-8	2002	The NEP inhibitor CGS24592 (10 microM) inhibited contractions induced by ET-1(1-31) (6.2-fold rightward shift; P&lt;0.05) but not ET-1(1-21) or big ET-1.	CGS 24592	18-26	endothelin 1	Mus musculus	73-77
12193144-0	2002	Effect of aging on gene expression rates of endothelin-1 and endothelin-2/vasoactive intestinal contractor in ethanol-induced gastric mucosal injury of the mouse.	Ethanol	110-117	endothelin 1	Mus musculus	44-56
12193144-1	2002	To elucidate the physiological roles of endothelin-1 (ET-1) and endothelin-2 (ET-2)/vasoactive intestinal contractor (VIC) in gastric injury of mice, we measured the gene expression rates of ET-1 and ET-2/VIC in gastric injury induced by ethanol in young (8 weeks) and old (&gt;33 weeks) mice.	Ethanol	238-245	endothelin 1	Mus musculus	191-195
12193144-4	2002	The gene expression of ET-1 tended to increase after 1 h and to decrease by 4 h of ethanol exposure in both young and old mice.	Ethanol	83-90	endothelin 1	Mus musculus	23-27
11907647-0	2002	Renal damage and salt-dependent hypertension in aged transgenic mice overexpressing endothelin-1.	Salts	17-21	endothelin 1	Mus musculus	84-96
12058957-4	2002	These effects of ET-1(1-31) and ET-1 were significantly inhibited by an ETA receptor antagonist, BQ-123, but not by an ETB receptor antagonist, BQ-788.	cyclo(Trp-Asp-Pro-Val-Leu)	97-103	endothelin 1	Mus musculus	17-21
12058957-4	2002	These effects of ET-1(1-31) and ET-1 were significantly inhibited by an ETA receptor antagonist, BQ-123, but not by an ETB receptor antagonist, BQ-788.	cyclo(Trp-Asp-Pro-Val-Leu)	97-103	endothelin 1	Mus musculus	32-36
11827700-8	2002	Treatment with darusentan normalized vascular structure, NO-mediated relaxation to acetylcholine and contractions to endothelin-1 and serotonin without affecting blood pressure or plasma cholesterol levels.	darusentan	15-25	endothelin 1	Mus musculus	117-129
11907647-9	2002	It thus appears that mild, chronic overproduction of ET-1 does not primarily cause hypertension but triggers damaging changes in the kidney which lead to the susceptibility to salt-induced hypertension.	Salts	176-180	endothelin 1	Mus musculus	53-57
11916961-8	2002	Endothelin-1, a peptide known to act on astrocytes, enhanced the production of anandamide, without affecting the levels of other acylethanolamides.	anandamide	79-89	endothelin 1	Mus musculus	0-12
11916961-8	2002	Endothelin-1, a peptide known to act on astrocytes, enhanced the production of anandamide, without affecting the levels of other acylethanolamides.	acylethanolamides	129-146	endothelin 1	Mus musculus	0-12
11972308-0	2002	Endothelin-1 stimulates glucose transport in murine 3T3 adipocyte lineage, but not in human subcutaneous fat cells.	Glucose	24-31	endothelin 1	Mus musculus	0-12
11755124-0	2001	Tissue- and time-dependent effects of endothelin-1 on insulin-stimulated glucose uptake.	Glucose	73-80	endothelin 1	Mus musculus	38-50
11848301-2	2002	endothelin-1 (ET-1) and phenylephrine are receptor agonists that share the signal transduction acting through acceleration of phosphoinositide hydrolysis in the heart.	Phosphatidylinositols	126-142	endothelin 1	Mus musculus	0-12
11848301-2	2002	endothelin-1 (ET-1) and phenylephrine are receptor agonists that share the signal transduction acting through acceleration of phosphoinositide hydrolysis in the heart.	Phosphatidylinositols	126-142	endothelin 1	Mus musculus	14-18
12397601-4	2002	SP600125, an inhibitor of JNK, markedly reduced the ET-1-induced VEGF synthesis.	pyrazolanthrone	0-8	endothelin 1	Mus musculus	52-56
12397601-5	2002	A combination of SP600125 and SB203580 additively reduced the ET-1-stimulated VEGF synthesis.	pyrazolanthrone	17-25	endothelin 1	Mus musculus	62-66
12397601-5	2002	A combination of SP600125 and SB203580 additively reduced the ET-1-stimulated VEGF synthesis.	SB 203580	30-38	endothelin 1	Mus musculus	62-66
12397601-6	2002	SP600125 suppressed the ET-1-induced phosphorylation of JNK, while having no effect on the phosphorylation of p38 MAP kinase elicited by ET-1.	pyrazolanthrone	0-8	endothelin 1	Mus musculus	24-28
11755124-1	2001	Hyperendothelinaemia is associated with various insulin-resistant states, e.g., diabetes, obesity and heart failure, but whether endothelin-1 (ET-1) has a direct effect on insulin-mediated glucose uptake is unclear because the interpretation of in vivo metabolic studies is complicated by ET-1 effects on muscle blood flow and insulin secretion.	Glucose	189-196	endothelin 1	Mus musculus	143-147
11755124-4	2001	ET-1 had no effect on basal (non-insulin-mediated) glucose transport, but there was evidence of a tissue- and time-dependent inhibitory effect of ET-1 on insulin-stimulated glucose uptake.	Glucose	173-180	endothelin 1	Mus musculus	146-150
11755124-5	2001	Specifically, ET-1 10 nM had a transient (0.5 h) inhibitory effect on glucose uptake in 3T3 cells (C(I-150) [dose of insulin required to increase glucose uptake by 50%, relative to control 100%] increased from 89 +/- 14 nM to 270 +/- 12 nM at 30 mins, P &lt; 0.05) but no effect on insulin sensitivity in L6 myoblasts (C(I-150) was 56 +/- 14 nM [control], 43 +/- 14 [30 mins] and 26 +/- 16 [2 h]).	Glucose	70-77	endothelin 1	Mus musculus	14-18
11755124-5	2001	Specifically, ET-1 10 nM had a transient (0.5 h) inhibitory effect on glucose uptake in 3T3 cells (C(I-150) [dose of insulin required to increase glucose uptake by 50%, relative to control 100%] increased from 89 +/- 14 nM to 270 +/- 12 nM at 30 mins, P &lt; 0.05) but no effect on insulin sensitivity in L6 myoblasts (C(I-150) was 56 +/- 14 nM [control], 43 +/- 14 [30 mins] and 26 +/- 16 [2 h]).	Glucose	146-153	endothelin 1	Mus musculus	14-18
11755124-6	2001	In conclusion, the inhibitory effect of ET-1 on insulin-stimulated glucose uptake is transient and occurs in 3T3-L1 adipocytes but not skeletal muscle-derived cells, perhaps reflecting tissue differences in ET(A)-receptor signaling.	Glucose	67-74	endothelin 1	Mus musculus	40-44
11701442-0	2001	Inhibition by adenylyl cyclase-cAMP system of ET-1-induced HSP27 in osteoblasts.	Cyclic AMP	31-35	endothelin 1	Mus musculus	46-50
11726808-2	2001	Here we studied ET-1-induced changes in intracellular calcium (Ca2+in) in Fura-2 loaded mouse neuroblastoma-rat dorsal root ganglion hybrid cells (ND7/104).	Calcium	54-61	endothelin 1	Mus musculus	16-20
11726808-2	2001	Here we studied ET-1-induced changes in intracellular calcium (Ca2+in) in Fura-2 loaded mouse neuroblastoma-rat dorsal root ganglion hybrid cells (ND7/104).	Fura-2	74-80	endothelin 1	Mus musculus	16-20
11701442-2	2001	In the present study, we investigated the effect of the adenylyl cyclase-cAMP system on ET-1-stimulated induction of HSP27 in MC3T3-E1 cells.	Cyclic AMP	73-77	endothelin 1	Mus musculus	88-92
11701442-3	2001	Dibutyryl-cAMP (DBcAMP) dose dependently inhibited the HSP27 accumulation stimulated by ET-1.	Bucladesine	0-14	endothelin 1	Mus musculus	88-92
11701442-3	2001	Dibutyryl-cAMP (DBcAMP) dose dependently inhibited the HSP27 accumulation stimulated by ET-1.	Bucladesine	16-22	endothelin 1	Mus musculus	88-92
11701442-4	2001	Forskolin and cholera toxin significantly suppressed the ET-1-stimulated accumulation of HSP27.	Colforsin	0-9	endothelin 1	Mus musculus	57-61
11701442-6	2001	Forskolin reduced the p38 MAP kinase phosphorylation induced by ET-1 or 12-O-tetradecanoylphorbol-13-acetate (TPA).	Colforsin	0-9	endothelin 1	Mus musculus	64-68
11701442-7	2001	PGE(1), an extracellular agonist that activates cAMP production, reduced the ET-1-induced HSP27 accumulation.	Alprostadil	0-6	endothelin 1	Mus musculus	77-81
11701442-7	2001	PGE(1), an extracellular agonist that activates cAMP production, reduced the ET-1-induced HSP27 accumulation.	Cyclic AMP	48-52	endothelin 1	Mus musculus	77-81
11701442-8	2001	In addition, the phosphorylation of p38 MAP kinase induced by ET-1 or TPA was suppressed by PGE(1).	Prostaglandins E	92-95	endothelin 1	Mus musculus	62-66
11701442-9	2001	Forskolin, DBcAMP, and PGE(1) suppressed the ET-1-stimulated increase in the mRNA level for HSP27.	Colforsin	0-9	endothelin 1	Mus musculus	45-49
11701442-9	2001	Forskolin, DBcAMP, and PGE(1) suppressed the ET-1-stimulated increase in the mRNA level for HSP27.	Bucladesine	11-17	endothelin 1	Mus musculus	45-49
11701442-9	2001	Forskolin, DBcAMP, and PGE(1) suppressed the ET-1-stimulated increase in the mRNA level for HSP27.	Prostaglandins E	23-26	endothelin 1	Mus musculus	45-49
11701442-10	2001	These results indicate that the adenylyl cyclase-cAMP system has an inhibitory role in ET-1-stimulated HSP27 induction in osteoblasts and that the effect is exerted at the point between PKC and p38 MAP kinase in osteoblasts.	Cyclic AMP	49-53	endothelin 1	Mus musculus	87-91
11431455-0	2001	Captopril improves retinal neovascularization via endothelin-1.	Captopril	0-9	endothelin 1	Mus musculus	50-62
11359784-6	2001	In addition, the ET(A)-selective antagonist FR139317 inhibited ET-1-induced leptin expression more potently than did the ET(B)-selective antagonist BQ788.	FR 139317	44-52	endothelin 1	Mus musculus	63-67
11560932-5	2001	In whole cell patch clamp experiments, we found that ET-1 treatment induced a dose-dependent decrease in amiloride-sensitive currents.	Amiloride	105-114	endothelin 1	Mus musculus	53-57
11431455-13	2001	At P17, there was a 6.2-fold suppression in ET-1 expression in captopril-treated animals when compared with the oxygen only-treated animals.	Captopril	63-72	endothelin 1	Mus musculus	44-48
11431455-15	2001	ET-1 expression is increased from P7 to P17, altered by hyperoxic exposure and relative hypoxic recovery and modulated by captopril in a mouse model of OIR.	Captopril	122-131	endothelin 1	Mus musculus	0-4
11078372-10	2000	Indomethacin (10 mg/kg), a nonselective cyclooxygenase inhibitor, abolished the inhibitory effect of ET-1.	Indomethacin	0-12	endothelin 1	Mus musculus	101-105
11181435-9	2001	An ETB-selective antagonist (BQ-788) or knockout of the B2 receptor gene (in B2 knockout mice) abolishes the platelet inhibitory properties of endothelin-1 and bradykinin, respectively.	BQ 788	29-35	endothelin 1	Mus musculus	143-155
11181435-12	2001	The inhibitory properties of endothelin-1 require the activation of COX-2 and the subsequent generation of prostacyclin.	Epoprostenol	107-119	endothelin 1	Mus musculus	29-41
11230349-1	2001	Estradiol inhibits endothelin-1 synthesis, an effect that may contribute to the cardiovascular protective effects of estradiol.	Estradiol	0-9	endothelin 1	Mus musculus	19-31
11230349-1	2001	Estradiol inhibits endothelin-1 synthesis, an effect that may contribute to the cardiovascular protective effects of estradiol.	Estradiol	117-126	endothelin 1	Mus musculus	19-31
11230349-4	2001	Treatment of porcine coronary artery endothelial cells for 4 to 24 hours with 0.001 to 1 micromol/L of estradiol, 2-hydroxyestradiol, or 2-methoxyestradiol concentration-dependently inhibited basal as well as serum-induced (2.5%), TNFalpha-induced (10 ng/mL), angiotensin II-induced (100 nmol/L), and thrombin-induced (4 U/mL) endothelin-1 synthesis.	Estradiol	103-112	endothelin 1	Mus musculus	327-339
11230349-4	2001	Treatment of porcine coronary artery endothelial cells for 4 to 24 hours with 0.001 to 1 micromol/L of estradiol, 2-hydroxyestradiol, or 2-methoxyestradiol concentration-dependently inhibited basal as well as serum-induced (2.5%), TNFalpha-induced (10 ng/mL), angiotensin II-induced (100 nmol/L), and thrombin-induced (4 U/mL) endothelin-1 synthesis.	2-hydroxyestradiol	114-132	endothelin 1	Mus musculus	327-339
11230349-4	2001	Treatment of porcine coronary artery endothelial cells for 4 to 24 hours with 0.001 to 1 micromol/L of estradiol, 2-hydroxyestradiol, or 2-methoxyestradiol concentration-dependently inhibited basal as well as serum-induced (2.5%), TNFalpha-induced (10 ng/mL), angiotensin II-induced (100 nmol/L), and thrombin-induced (4 U/mL) endothelin-1 synthesis.	2-Methoxyestradiol	137-155	endothelin 1	Mus musculus	327-339
11230349-6	2001	As compared with estradiol, its metabolites were more potent in inhibiting endothelin-1 secretion and mitogen activated protein kinase activity.	Estradiol	17-26	endothelin 1	Mus musculus	75-87
11230349-7	2001	The inhibitory effects of 2-hydroxyestradiol and 2-methoxyestradiol on endothelin-1 release and mitogen-activated protein kinase activity were not blocked by ICI182780 (50 micromol/L), an estrogen receptor antagonist.	2-hydroxyestradiol	26-44	endothelin 1	Mus musculus	71-83
11230349-7	2001	The inhibitory effects of 2-hydroxyestradiol and 2-methoxyestradiol on endothelin-1 release and mitogen-activated protein kinase activity were not blocked by ICI182780 (50 micromol/L), an estrogen receptor antagonist.	2-Methoxyestradiol	49-67	endothelin 1	Mus musculus	71-83
11230349-8	2001	Our findings indicate that the estradiol metabolites 2-hydroxyestradiol and 2-methoxyestradiol potently inhibit endothelin-1 synthesis by means of an estrogen receptor-independent mechanism.	2-hydroxyestradiol	53-71	endothelin 1	Mus musculus	112-124
11230349-8	2001	Our findings indicate that the estradiol metabolites 2-hydroxyestradiol and 2-methoxyestradiol potently inhibit endothelin-1 synthesis by means of an estrogen receptor-independent mechanism.	2-Methoxyestradiol	76-94	endothelin 1	Mus musculus	112-124
11116115-7	2000	In wild-type mice, both ET(A) and ET(B) receptors were found to be involved in the pressor effect of ET-1, as confirmed by the significant and specific antagonism induced by either BQ-123 (ET(A) antagonist) or BQ-788 (ET(B) antagonist).	cyclo(Trp-Asp-Pro-Val-Leu)	181-187	endothelin 1	Mus musculus	101-105
11078341-1	2000	Experiments were carried out in mutant 129/SvEv mice lacking the endothelin-A (ET(A))-receptor to determine whether endothelin-1 (ET-1), acting as a messenger for oxygen constriction, is responsible for closure of the ductus arteriosus at birth.	Oxygen	163-169	endothelin 1	Mus musculus	130-134
11078341-6	2000	We conclude that ET-1 mediates the ductus constriction to oxygen.	Oxygen	58-64	endothelin 1	Mus musculus	17-21
11500953-0	2001	Stimulatory effect of endothelin-1 on Na-dependent phosphate transport and its signaling mechanism in osteoblast-like cells.	Phosphates	51-60	endothelin 1	Mus musculus	22-34
11500953-2	2001	In the present study, we investigated the effect of ET-1 on inorganic phosphate (Pi) transport in osteoblast-like cells, which is now considered to be important for the initiation of bone matrix calcification.	Phosphates	60-79	endothelin 1	Mus musculus	52-56
11500953-5	2001	BQ123, a selective antagonist for ET(A) receptor, suppressed the ET-1-induced Pi transport, but BQ788, a selective antagonist for ET(B) receptor, had no effect.	cyclo(Trp-Asp-Pro-Val-Leu)	0-5	endothelin 1	Mus musculus	65-69
11500953-6	2001	The inhibition of phosphoinositide hydrolysis by phospholipase C (PLC) partially attenuated the Pi transport by ET-1.	Phosphatidylinositols	18-34	endothelin 1	Mus musculus	112-116
11500953-7	2001	Propranolol, which inhibits phosphatidic acid phosphohydrolase, also suppressed ET-1-induced Pi transport.	Propranolol	0-11	endothelin 1	Mus musculus	80-84
11500953-9	2001	Calphostin C, a protein kinase C (PKC) inhibitor, significantly blunted the stimulatory effect of ET-1 on Pi transport.	calphostin C	0-12	endothelin 1	Mus musculus	98-102
11500953-12	2001	In conclusion, the results of the present study indicate that in MC3T3-E1 osteoblast-like cells, ET-1 acting through ET receptor links to a stimulation of Pi transport via activation of PKC through both phosphoinositide and phosphatidylcholine hydrolyses.	Phosphatidylinositols	203-219	endothelin 1	Mus musculus	97-101
11500953-12	2001	In conclusion, the results of the present study indicate that in MC3T3-E1 osteoblast-like cells, ET-1 acting through ET receptor links to a stimulation of Pi transport via activation of PKC through both phosphoinositide and phosphatidylcholine hydrolyses.	Phosphatidylcholines	224-243	endothelin 1	Mus musculus	97-101
11243417-0	2001	KB-R7943, a selective Na+/Ca2+ exchange inhibitor, protects against ischemic acute renal failure in mice by inhibiting renal endothelin-1 overproduction.	2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate	0-8	endothelin 1	Mus musculus	125-137
11116115-7	2000	In wild-type mice, both ET(A) and ET(B) receptors were found to be involved in the pressor effect of ET-1, as confirmed by the significant and specific antagonism induced by either BQ-123 (ET(A) antagonist) or BQ-788 (ET(B) antagonist).	BQ 788	210-216	endothelin 1	Mus musculus	101-105
11078372-12	2000	The selective ET(B) antagonist, BQ-788 (0.5 nmol/kg), did not modify the elevation of blood pressure produced by the ET-1; however, it did abrogate dose-dependently the inhibitory effect of ET-1 on platelet aggregation.	BQ 788	32-38	endothelin 1	Mus musculus	190-194
11078372-14	2000	The mechanism whereby ET-1 exerts this effect, is partially indirect and requires at least the production and the release of prostanoids (possibly PGI2) into the blood stream.	Prostaglandins	125-136	endothelin 1	Mus musculus	22-26
11078388-4	2000	Chronic LU135252 treatment completely prevented activation of renal ACE activity (13.3 +/- 0.3 His-Leu/mg protein nmol/l, p &lt; 0.05) independent of ACE mRNA expression or renal ET-1 protein levels.	darusentan	8-16	endothelin 1	Mus musculus	179-183
11078372-11	2000	The selective ET(A) antagonist, BQ-123 (1 nmol/kg), abolished the in vivo pressor effect of exogenous ET-1, without affecting its anti-aggregatory activity.	cyclo(Trp-Asp-Pro-Val-Leu)	32-38	endothelin 1	Mus musculus	102-106
10889466-7	2000	Calphostin C, a specific PKC inhibitor, suppressed the VEGF secretion by ET-1.	calphostin C	0-12	endothelin 1	Mus musculus	73-77
10938240-5	2000	Hypothalamic levels of ET-1 and the catecholamine metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) were both increased in wild-type mice subjected to intruder stress, whereas MHPG levels were not significantly affected in ET-1-knockout mice.	Methoxyhydroxyphenylglycol	176-180	endothelin 1	Mus musculus	23-27
10938240-6	2000	Furthermore, immunohistochemical analysis showed that ET-1 and tyrosine hydroxylase, an enzyme in the catecholamine synthesis pathway, were colocalized within certain neurons of the hypothalamus and amygdala.	Catecholamines	102-115	endothelin 1	Mus musculus	54-83
10938240-7	2000	Our findings suggest that ET-1 modulates central coordination of stress responses in close association with catecholamine metabolism.	Catecholamines	108-121	endothelin 1	Mus musculus	26-30
10903961-3	2000	Osteoblast-like MC3T3-E1 cells stimulated by endothelin-1, melittin, ionomycin or arachidonic acid showed diminished prostaglandin E(2) (PGE(2)) production upon pretreatment with econazole.	Dinoprostone	117-135	endothelin 1	Mus musculus	45-57
10903961-3	2000	Osteoblast-like MC3T3-E1 cells stimulated by endothelin-1, melittin, ionomycin or arachidonic acid showed diminished prostaglandin E(2) (PGE(2)) production upon pretreatment with econazole.	Prostaglandins E	137-140	endothelin 1	Mus musculus	45-57
10903961-3	2000	Osteoblast-like MC3T3-E1 cells stimulated by endothelin-1, melittin, ionomycin or arachidonic acid showed diminished prostaglandin E(2) (PGE(2)) production upon pretreatment with econazole.	Econazole	179-188	endothelin 1	Mus musculus	45-57
10889466-4	2000	The stimulatory effect was dose-dependent in the range between 0.1 nM and 0.1 micro;M. BQ123, an antagonist of endothelin(A) (ET(A)) receptor, inhibited the ET-1-induced VEGF secretion.	cyclo(Trp-Asp-Pro-Val-Leu)	87-92	endothelin 1	Mus musculus	157-161
10889466-5	2000	The ET-1-induced VEGF secretion was suppressed by SB203580 and PD169316, inhibitors of p38 MAP kinase, but not PD98059, an inhibitor of the upstream kinase that activates p44/p42 MAP kinase.	SB 203580	50-58	endothelin 1	Mus musculus	4-8
10889466-5	2000	The ET-1-induced VEGF secretion was suppressed by SB203580 and PD169316, inhibitors of p38 MAP kinase, but not PD98059, an inhibitor of the upstream kinase that activates p44/p42 MAP kinase.	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole	63-71	endothelin 1	Mus musculus	4-8
11121595-0	2000	Endothelin-1 is involved in the growth promotion of vascular smooth muscle cells by hyaluronic acid.	Hyaluronic Acid	84-99	endothelin 1	Mus musculus	0-12
11121595-6	2000	ET-1 reversed the reduction of CD44 expression by phosphoramidon.	phosphoramidon	50-64	endothelin 1	Mus musculus	0-4
11121595-7	2000	Because CD44 is a receptor for HA, we investigated the effects of phosphoramidon, BQ-123 or ET-1 on the mitogenic activity of HA in VSMC.	vsmc	132-136	endothelin 1	Mus musculus	92-96
11121595-10	2000	ET-1 reversed the suppression of oHA-induced proliferation by phosphoramidon.	10-oxohexadecanoic acid	33-36	endothelin 1	Mus musculus	0-4
11121595-10	2000	ET-1 reversed the suppression of oHA-induced proliferation by phosphoramidon.	phosphoramidon	62-76	endothelin 1	Mus musculus	0-4
11121595-12	2000	Thus it is suggested that the CD44-inducing activity of ET-1 is responsible for its stimulating effect on oHA-dependent growth of VSMC.	10-oxohexadecanoic acid	106-109	endothelin 1	Mus musculus	56-60
11121595-12	2000	Thus it is suggested that the CD44-inducing activity of ET-1 is responsible for its stimulating effect on oHA-dependent growth of VSMC.	vsmc	130-134	endothelin 1	Mus musculus	56-60
10900237-5	2000	Angiotensin II and endothelin-1 were weakly efficacious (15% of maximum phenylephrine contraction), as were UK14,304, clonidine, histamine, and adenosine.	Phenylephrine	72-85	endothelin 1	Mus musculus	19-31
10696096-1	2000	Endothelin-1 causes ET(A) receptor-mediated enhancement of capsaicin-induced nociception in mice.	Capsaicin	59-68	endothelin 1	Mus musculus	0-12
10822063-7	2000	Endothelin-1 (300 nM) translocated protein kinase C from cytosol to membrane, suggesting activation of protein kinase C. Further, a selective protein kinase C inhibitor, bisindolylmaleimide I (10 microM), inhibited the endothelin-1-induced negative inotropy.	bisindolylmaleimide I	170-191	endothelin 1	Mus musculus	0-12
10822063-7	2000	Endothelin-1 (300 nM) translocated protein kinase C from cytosol to membrane, suggesting activation of protein kinase C. Further, a selective protein kinase C inhibitor, bisindolylmaleimide I (10 microM), inhibited the endothelin-1-induced negative inotropy.	bisindolylmaleimide I	170-191	endothelin 1	Mus musculus	219-231
10822063-3	2000	The endothelin-1-induced negative inotropy was antagonized by a selective endothelin ET(A) receptor antagonist, BQ-123 (cyclo ?Asp-Pro-Val-Leu-Trp-; 3, 10 microM).	cyclo(Trp-Asp-Pro-Val-Leu)	112-118	endothelin 1	Mus musculus	4-16
10822063-3	2000	The endothelin-1-induced negative inotropy was antagonized by a selective endothelin ET(A) receptor antagonist, BQ-123 (cyclo ?Asp-Pro-Val-Leu-Trp-; 3, 10 microM).	emodepside	120-125	endothelin 1	Mus musculus	4-16
10822063-3	2000	The endothelin-1-induced negative inotropy was antagonized by a selective endothelin ET(A) receptor antagonist, BQ-123 (cyclo ?Asp-Pro-Val-Leu-Trp-; 3, 10 microM).	asp-pro-val-leu-trp	127-146	endothelin 1	Mus musculus	4-16
10690956-5	2000	ET-1 (100 nmol/L) stimulated insulin secretion from islets incubated at 8.3, 11.1, 16.7, and 25 mmol/L glucose (P &lt; .05).	Glucose	103-110	endothelin 1	Mus musculus	0-4
10855694-4	2000	Furthermore, several studies have shown that ET-1 stimulates the formation of inositol phosphates, the synthesis of DNA, the mobilization of calcium from extra- and intracellular pools, the activation of phospholipase D, and the stimulation of tyrosine phosphorylation in osteoblast-like (MC3T3-E1 and UMR-106) cells.	Inositol Phosphates	78-97	endothelin 1	Mus musculus	45-49
10855694-4	2000	Furthermore, several studies have shown that ET-1 stimulates the formation of inositol phosphates, the synthesis of DNA, the mobilization of calcium from extra- and intracellular pools, the activation of phospholipase D, and the stimulation of tyrosine phosphorylation in osteoblast-like (MC3T3-E1 and UMR-106) cells.	Calcium	141-148	endothelin 1	Mus musculus	45-49
10855694-4	2000	Furthermore, several studies have shown that ET-1 stimulates the formation of inositol phosphates, the synthesis of DNA, the mobilization of calcium from extra- and intracellular pools, the activation of phospholipase D, and the stimulation of tyrosine phosphorylation in osteoblast-like (MC3T3-E1 and UMR-106) cells.	Tyrosine	244-252	endothelin 1	Mus musculus	45-49
10690956-9	2000	We also studied the relative role of protein kinase C (PKC) and a Wortmannin-sensitive pathway for ET-1-induced insulin secretion using 12-O-tetradecanoyl phorbol-13-acetate (TPA), Calphostin C, and Wortmannin, respectively.	Wortmannin	66-76	endothelin 1	Mus musculus	99-103
10690956-11	2000	Furthermore, the insulinotropic effect of ET-1 at 16.7 mmol/L glucose was counteracted by the PKC inhibitor Calphostin C (P &lt; .05) and by downregulation of PKC by 24 hours of exposure of islets to TPA (0.5 micromol/L, P &lt; .05).	Glucose	62-69	endothelin 1	Mus musculus	42-46
10690956-11	2000	Furthermore, the insulinotropic effect of ET-1 at 16.7 mmol/L glucose was counteracted by the PKC inhibitor Calphostin C (P &lt; .05) and by downregulation of PKC by 24 hours of exposure of islets to TPA (0.5 micromol/L, P &lt; .05).	calphostin C	108-120	endothelin 1	Mus musculus	42-46
10690956-11	2000	Furthermore, the insulinotropic effect of ET-1 at 16.7 mmol/L glucose was counteracted by the PKC inhibitor Calphostin C (P &lt; .05) and by downregulation of PKC by 24 hours of exposure of islets to TPA (0.5 micromol/L, P &lt; .05).	Tetradecanoylphorbol Acetate	200-203	endothelin 1	Mus musculus	42-46
10600794-5	1999	Both staurosporine and calphostin C, inhibitors of protein kinase C (PKC), suppressed the ET-1-induced HSP 27 accumulation.	Staurosporine	5-18	endothelin 1	Mus musculus	90-94
10600794-11	1999	Calphostin C and U-73122, a phospholipase C inhibitor, suppressed the ET-1-induced phosphorylation of p38 MAP kinase.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	17-24	endothelin 1	Mus musculus	70-74
10600794-12	1999	U-73122 and propranolol, a phosphatidic acid phosphohydrolase inhibitor, reduced the ET-1-stimulated HSP 27 accumulation.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	0-7	endothelin 1	Mus musculus	85-89
10600794-5	1999	Both staurosporine and calphostin C, inhibitors of protein kinase C (PKC), suppressed the ET-1-induced HSP 27 accumulation.	calphostin C	23-35	endothelin 1	Mus musculus	90-94
10600794-12	1999	U-73122 and propranolol, a phosphatidic acid phosphohydrolase inhibitor, reduced the ET-1-stimulated HSP 27 accumulation.	Propranolol	12-23	endothelin 1	Mus musculus	85-89
10600794-10	1999	SB-203580, an inhibitor of p38 MAP kinase, reduced the ET-1-stimulated HSP 27 accumulation.	SB 203580	0-9	endothelin 1	Mus musculus	55-59
10600794-13	1999	SB-203580 suppressed the ET-1-stimulated increase in the mRNA levels for HSP 27.	SB 203580	0-9	endothelin 1	Mus musculus	25-29
10600794-11	1999	Calphostin C and U-73122, a phospholipase C inhibitor, suppressed the ET-1-induced phosphorylation of p38 MAP kinase.	calphostin C	0-12	endothelin 1	Mus musculus	70-74
10601144-0	1999	Disruption of ET-1 gene enhances pulmonary responses to methacholine via functional mechanism in knockout mice.	Methacholine Chloride	56-68	endothelin 1	Mus musculus	14-18
10626068-12	1999	In ET-1+/- mice, PCO2 tended to be higher and PO2 was significantly lower than corresponding values in ET-1+/+ mice.	pco2	17-21	endothelin 1	Mus musculus	3-7
10626068-12	1999	In ET-1+/- mice, PCO2 tended to be higher and PO2 was significantly lower than corresponding values in ET-1+/+ mice.	PO-2	46-49	endothelin 1	Mus musculus	3-7
10601144-6	1999	In the physiological study, enhanced responses in lung elastance and resistance to methacholine administration were observed in Edn1(+/-) mice, whereas there was no difference in serotonin responsiveness.	Methacholine Chloride	83-95	endothelin 1	Mus musculus	128-132
10601144-8	1999	These findings suggest that ET-1 gene disruption is involved in methacholine pulmonary hyperresponsiveness via functional mechanism, but not airway remodeling, in mice.	Methacholine Chloride	64-76	endothelin 1	Mus musculus	28-32
10534471-7	1999	Oral bosentan, a mixed ET-1 receptor antagonist, was administered after virus inoculation in doses of 0 (control group), 10, or 100 mg. kg(-1).	Bosentan	5-13	endothelin 1	Mus musculus	23-27
10516105-9	1999	Calphostin C inhibited 73% of ET-1-induced Gardos activation and 84% of the ET-1-induced membrane protein kinase C activity.	calphostin C	0-12	endothelin 1	Mus musculus	30-34
10516105-9	1999	Calphostin C inhibited 73% of ET-1-induced Gardos activation and 84% of the ET-1-induced membrane protein kinase C activity.	calphostin C	0-12	endothelin 1	Mus musculus	76-80
10221543-4	1999	PD98059, a specific inhibitor of the upstream kinase that activates p42/p44 MAP kinase, suppressed endothelin-1-induced IL-6 synthesis as well as endothelin-1-activated p42/p44 MAP kinase.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	endothelin 1	Mus musculus	99-111
10221543-6	1999	Calphostin C, a highly specific inhibitor of protein kinase C, suppressed endothelin-1-stimulated p42/p44 MAP kinase activation as well as endothelin-1-induced IL-6 synthesis.	calphostin C	0-12	endothelin 1	Mus musculus	74-86
10516191-10	1999	We conclude that ET-1 mediates the DA constrictor response to O(2).	o(2)	62-66	endothelin 1	Mus musculus	17-21
10221543-4	1999	PD98059, a specific inhibitor of the upstream kinase that activates p42/p44 MAP kinase, suppressed endothelin-1-induced IL-6 synthesis as well as endothelin-1-activated p42/p44 MAP kinase.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	endothelin 1	Mus musculus	146-158
10221543-6	1999	Calphostin C, a highly specific inhibitor of protein kinase C, suppressed endothelin-1-stimulated p42/p44 MAP kinase activation as well as endothelin-1-induced IL-6 synthesis.	calphostin C	0-12	endothelin 1	Mus musculus	139-151
10082482-5	1999	ET-1-induced increase in cyclin D1 protein, and cdk4 kinase activity was not significantly inhibited by an inhibitor of the mitogen-activated protein kinase kinase 1/2, PD98059, nor by the protein kinase C inhibitor calphostin C, whereas ET-1-induced upregulation of cyclin D1 protein and cdk4 kinase activity was significantly inhibited by the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	169-176	endothelin 1	Mus musculus	0-4
10221345-0	1999	Responses of blood pressure and catecholamine metabolism to high salt loading in endothelin-1 knockout mice.	Salts	65-69	endothelin 1	Mus musculus	81-93
10221345-3	1999	In the present study, we used this mouse model to examine the degree to which ET-1 contributes to the responses of blood pressure and catecholamine metabolism to high salt loading.	Catecholamines	134-147	endothelin 1	Mus musculus	78-82
10221345-3	1999	In the present study, we used this mouse model to examine the degree to which ET-1 contributes to the responses of blood pressure and catecholamine metabolism to high salt loading.	Salts	167-171	endothelin 1	Mus musculus	78-82
10075711-2	1999	This report studies the effect of ET-1 on regulating glucose transport in 3T3-L1 adipocytes.	Glucose	53-60	endothelin 1	Mus musculus	34-38
10075711-3	1999	ET-1, but not angiotensin II, stimulated glucose uptake in a dose-dependent manner with an EC50 value of 0.29 nM and a 2.47-fold stimulation at 100 nM.	Glucose	41-48	endothelin 1	Mus musculus	0-4
10075711-4	1999	ET-1 stimulated glucose uptake in differentiated 3T3-L1 cells but had no effect in undifferentiated cells, although ET-1 stimulated phosphatidylinositol hydrolysis to a similar degree in both.	Glucose	16-23	endothelin 1	Mus musculus	0-4
10075711-4	1999	ET-1 stimulated glucose uptake in differentiated 3T3-L1 cells but had no effect in undifferentiated cells, although ET-1 stimulated phosphatidylinositol hydrolysis to a similar degree in both.	Phosphatidylinositols	132-152	endothelin 1	Mus musculus	116-120
10075711-7	1999	The effect of ET-1 on glucose uptake was blocked by A-216546, an antagonist selective for the ETA receptor.	Glucose	22-29	endothelin 1	Mus musculus	14-18
10075711-7	1999	The effect of ET-1 on glucose uptake was blocked by A-216546, an antagonist selective for the ETA receptor.	A 216546	52-60	endothelin 1	Mus musculus	14-18
10075711-8	1999	ET-1 treatment did not induce phosphorylation of insulin receptor beta-subunit, insulin receptor substrate-1, or Akt but stimulated the tyrosyl phosphorylation of a 75-kDa protein.	cyclo(tyrosyl-tyrosyl)	136-143	endothelin 1	Mus musculus	0-4
10075711-9	1999	Genistein (100 microM), an inhibitor of tyrosine kinases, inhibited ET-1-stimulated glucose uptake.	Genistein	0-9	endothelin 1	Mus musculus	68-72
10075711-9	1999	Genistein (100 microM), an inhibitor of tyrosine kinases, inhibited ET-1-stimulated glucose uptake.	Glucose	84-91	endothelin 1	Mus musculus	68-72
10075711-10	1999	Our results show that ET-1 stimulates GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes via activation of ETA receptor.	Glucose	62-69	endothelin 1	Mus musculus	22-26
10221345-5	1999	During the normal diet, renal ET-1 levels in Edn1+/- mice were approximately 50% lower than ET-1 levels in wild-type mice, whereas the high salt diet decreased renal ET-1 levels by about 50% in both Edn1+/- and wild-type mice.	Salts	140-144	endothelin 1	Mus musculus	199-203
10221345-9	1999	We conclude that physiological changes in ET-1 production do not affect the responses of blood pressure and catecholamine metabolism to salt loading, although the renal ET-1 content is decreased by salt loading.	Salts	198-202	endothelin 1	Mus musculus	169-173
10082482-5	1999	ET-1-induced increase in cyclin D1 protein, and cdk4 kinase activity was not significantly inhibited by an inhibitor of the mitogen-activated protein kinase kinase 1/2, PD98059, nor by the protein kinase C inhibitor calphostin C, whereas ET-1-induced upregulation of cyclin D1 protein and cdk4 kinase activity was significantly inhibited by the phosphatidylinositol 3-kinase inhibitor LY294002.	calphostin C	216-228	endothelin 1	Mus musculus	0-4
10082482-5	1999	ET-1-induced increase in cyclin D1 protein, and cdk4 kinase activity was not significantly inhibited by an inhibitor of the mitogen-activated protein kinase kinase 1/2, PD98059, nor by the protein kinase C inhibitor calphostin C, whereas ET-1-induced upregulation of cyclin D1 protein and cdk4 kinase activity was significantly inhibited by the phosphatidylinositol 3-kinase inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	385-393	endothelin 1	Mus musculus	0-4
10082482-6	1999	In contrast, ET-1-induced activation of cdk2 kinase was significantly inhibited by PD98059, calphostin C, and LY294002.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	83-90	endothelin 1	Mus musculus	13-17
10082482-6	1999	In contrast, ET-1-induced activation of cdk2 kinase was significantly inhibited by PD98059, calphostin C, and LY294002.	calphostin C	92-104	endothelin 1	Mus musculus	13-17
10082482-6	1999	In contrast, ET-1-induced activation of cdk2 kinase was significantly inhibited by PD98059, calphostin C, and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	endothelin 1	Mus musculus	13-17
10432173-0	1999	Acetoacetate and beta-hydroxybutyrate differentially regulate endothelin-1 and vascular endothelial growth factor in mouse brain microvascular endothelial cells.	acetoacetic acid	0-12	endothelin 1	Mus musculus	62-74
10082482-7	1999	ET-1 increased 3H-thymidine uptake in a time-dependent fashion (0 hours, 4216+/-264 cpm per well; 8 hours, 5025+/-197 cpm per well; 16 hours, 9239+/-79 cpm per well, P&lt;0.001 versus 0 hours).	3h-thymidine	15-27	endothelin 1	Mus musculus	0-4
10432173-0	1999	Acetoacetate and beta-hydroxybutyrate differentially regulate endothelin-1 and vascular endothelial growth factor in mouse brain microvascular endothelial cells.	3-Hydroxybutyric Acid	17-37	endothelin 1	Mus musculus	62-74
10432173-13	1999	In contrast, AcAc increases the production of the potent vasoconstrictor, endothelin-1.	acetoacetic acid	13-17	endothelin 1	Mus musculus	74-86
10082482-8	1999	ET-1-induced increase in 3H-thymidine uptake was significantly inhibited by PD98059, calphostin C, and LY294002.	3h-thymidine	25-37	endothelin 1	Mus musculus	0-4
10082482-8	1999	ET-1-induced increase in 3H-thymidine uptake was significantly inhibited by PD98059, calphostin C, and LY294002.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	76-83	endothelin 1	Mus musculus	0-4
10082482-8	1999	ET-1-induced increase in 3H-thymidine uptake was significantly inhibited by PD98059, calphostin C, and LY294002.	calphostin C	85-97	endothelin 1	Mus musculus	0-4
10082482-8	1999	ET-1-induced increase in 3H-thymidine uptake was significantly inhibited by PD98059, calphostin C, and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	endothelin 1	Mus musculus	0-4
10189964-2	1999	In particular, hormones such as angiotensin II, endothelin 1, norepinephrine and prostaglandin F2 alpha which bind to and activate cardiomyocyte membrane receptors coupled to the Gq class of GTP binding proteins have been implicated in the development and ultimate decompensation of cardiac hypertrophy.	Norepinephrine	62-76	endothelin 1	Mus musculus	48-60
10189964-2	1999	In particular, hormones such as angiotensin II, endothelin 1, norepinephrine and prostaglandin F2 alpha which bind to and activate cardiomyocyte membrane receptors coupled to the Gq class of GTP binding proteins have been implicated in the development and ultimate decompensation of cardiac hypertrophy.	Guanosine Triphosphate	191-194	endothelin 1	Mus musculus	48-60
9756539-5	1998	ET-1 also decreased in the deposition of calcium by MC3T3-E1 cells in a dose-dependent manner and it had an inhibitory effect even at 10(-11) M. The rank order of potency of ETs was ET-1 = ET-2 &gt; ET-3.	Calcium	41-48	endothelin 1	Mus musculus	0-4
9767170-8	1998	On the other hand, resting RSNA, RSNA range, and maximum RSNA were significantly greater in ET-1 deficient mice, and thus MAP-RSNA relationship was upwards reset.	rsna	27-31	endothelin 1	Mus musculus	92-96
9767170-8	1998	On the other hand, resting RSNA, RSNA range, and maximum RSNA were significantly greater in ET-1 deficient mice, and thus MAP-RSNA relationship was upwards reset.	rsna	33-37	endothelin 1	Mus musculus	92-96
9767170-8	1998	On the other hand, resting RSNA, RSNA range, and maximum RSNA were significantly greater in ET-1 deficient mice, and thus MAP-RSNA relationship was upwards reset.	rsna	33-37	endothelin 1	Mus musculus	92-96
9767170-8	1998	On the other hand, resting RSNA, RSNA range, and maximum RSNA were significantly greater in ET-1 deficient mice, and thus MAP-RSNA relationship was upwards reset.	rsna	33-37	endothelin 1	Mus musculus	92-96
9861441-3	1998	The endothelin 1 stimulation of the mouse stomach tone was abolished by the specific serotonin antagonist methizergid.	Serotonin	85-94	endothelin 1	Mus musculus	4-16
9861441-6	1998	Complete reduction of Ca++ from the extracellular solution with a simultaneous depletion of calcium stores abolished endothelin 1 depolarization of BC3H1 cells.	Calcium	92-99	endothelin 1	Mus musculus	117-129
9756539-7	1998	ET-1 enhanced the rate of production of inositol 1,4, 5-trisphosphate (IP3) in MC3T3-E1 cells, but it had no effect on the rate of production of cAMP.	Inositol 1,4,5-Trisphosphate	40-69	endothelin 1	Mus musculus	0-4
9767170-10	1998	These results indicate that endogenous ET-1 participates in the central chemoreception of CO2 and reflex control of the RSNA.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	90-93	endothelin 1	Mus musculus	39-43
9767170-10	1998	These results indicate that endogenous ET-1 participates in the central chemoreception of CO2 and reflex control of the RSNA.	rsna	120-124	endothelin 1	Mus musculus	39-43
9756539-7	1998	ET-1 enhanced the rate of production of inositol 1,4, 5-trisphosphate (IP3) in MC3T3-E1 cells, but it had no effect on the rate of production of cAMP.	Inositol 1,4,5-Trisphosphate	71-74	endothelin 1	Mus musculus	0-4
9756539-8	1998	Taken together, our data indicate that ET-1 might inhibit the mineralization of osteoblastic cells via an interaction with the ETA receptor, with generation of IP3 as the intracellular signal.	Inositol 1,4,5-Trisphosphate	160-163	endothelin 1	Mus musculus	39-43
9761426-8	1998	We conclude that endothelin-1 increases cyclooxygenase 2 protein expression and prostaglandin E2 production via mainly endothelin ET(B) receptors and partly endothelin ET(A) receptors in macrophages; however, lipopolysaccharide increases both cyclooxygenase 2 protein expression and prostaglandin E2 production in pacrophages without involving endothelin ET(A) or ET(B) receptor-mediated processes.	Dinoprostone	283-299	endothelin 1	Mus musculus	17-29
9481485-4	1998	BQ123, a selective antagonist of endothelinA (ETA) receptor, inhibited the ET-1-induced IL-6 secretion.	cyclo(Trp-Asp-Pro-Val-Leu)	0-5	endothelin 1	Mus musculus	75-79
9476873-0	1998	Airway hyperresponsiveness to methacholine in mutant mice deficient in endothelin-1.	Methacholine Chloride	30-42	endothelin 1	Mus musculus	71-83
9476873-5	1998	Unexpectedly, airway responsiveness to methacholine was markedly enhanced in ET-1(+/-) heterozygous mice as compared with ET-1(+/+) wild-type mice (EC200 RL: 1.8 +/- 0.1 versus 21.6 +/- 5.6 mg/ml, p &lt; 0.002).	Methacholine Chloride	39-51	endothelin 1	Mus musculus	77-81
9476873-6	1998	Pretreatment with the nitric oxide (NO) synthase inhibitor Ng-monomethyl-L-arginine (L-NMMA) significantly enhanced methacholine responsiveness in ET-1(+/+) wild-type mice, but not in ET-1(+/-) heterozygous mice.	Nitric Oxide	22-34	endothelin 1	Mus musculus	147-151
9476873-6	1998	Pretreatment with the nitric oxide (NO) synthase inhibitor Ng-monomethyl-L-arginine (L-NMMA) significantly enhanced methacholine responsiveness in ET-1(+/+) wild-type mice, but not in ET-1(+/-) heterozygous mice.	Nitric Oxide	22-34	endothelin 1	Mus musculus	184-188
9476873-6	1998	Pretreatment with the nitric oxide (NO) synthase inhibitor Ng-monomethyl-L-arginine (L-NMMA) significantly enhanced methacholine responsiveness in ET-1(+/+) wild-type mice, but not in ET-1(+/-) heterozygous mice.	omega-N-Methylarginine	59-83	endothelin 1	Mus musculus	147-151
9476873-6	1998	Pretreatment with the nitric oxide (NO) synthase inhibitor Ng-monomethyl-L-arginine (L-NMMA) significantly enhanced methacholine responsiveness in ET-1(+/+) wild-type mice, but not in ET-1(+/-) heterozygous mice.	omega-N-Methylarginine	85-91	endothelin 1	Mus musculus	147-151
9476873-6	1998	Pretreatment with the nitric oxide (NO) synthase inhibitor Ng-monomethyl-L-arginine (L-NMMA) significantly enhanced methacholine responsiveness in ET-1(+/+) wild-type mice, but not in ET-1(+/-) heterozygous mice.	omega-N-Methylarginine	85-91	endothelin 1	Mus musculus	184-188
9476873-6	1998	Pretreatment with the nitric oxide (NO) synthase inhibitor Ng-monomethyl-L-arginine (L-NMMA) significantly enhanced methacholine responsiveness in ET-1(+/+) wild-type mice, but not in ET-1(+/-) heterozygous mice.	Methacholine Chloride	116-128	endothelin 1	Mus musculus	147-151
9476873-9	1998	These findings suggest that the gene encoding ET-1 may be potentially involved in the etiology of airway hyperreactivity, and that the decrease in ET-1 concentration is associated with AHR to methacholine.	Methacholine Chloride	192-204	endothelin 1	Mus musculus	46-50
9476873-9	1998	These findings suggest that the gene encoding ET-1 may be potentially involved in the etiology of airway hyperreactivity, and that the decrease in ET-1 concentration is associated with AHR to methacholine.	Methacholine Chloride	192-204	endothelin 1	Mus musculus	147-151
9761426-8	1998	We conclude that endothelin-1 increases cyclooxygenase 2 protein expression and prostaglandin E2 production via mainly endothelin ET(B) receptors and partly endothelin ET(A) receptors in macrophages; however, lipopolysaccharide increases both cyclooxygenase 2 protein expression and prostaglandin E2 production in pacrophages without involving endothelin ET(A) or ET(B) receptor-mediated processes.	Dinoprostone	80-96	endothelin 1	Mus musculus	17-29
9698200-0	1998	Effects of endothelin-1 on capsaicin-induced nociception in mice.	Capsaicin	27-36	endothelin 1	Mus musculus	11-23
9698200-1	1998	The influence of endothelin-1 on nociception induced by capsaicin was assessed in the mouse hindpaw.	Capsaicin	56-65	endothelin 1	Mus musculus	17-29
9698200-2	1998	Local endothelin-1 injection (1 to 20 pmol/paw) 30 min prior to ipsilateral injection of capsaicin (0.1 microg/paw) increased, in a graded fashion, the time spent licking the injected paw.	Capsaicin	89-98	endothelin 1	Mus musculus	6-18
9698200-3	1998	Maximal hyperalgesia was obtained with 10 pmol/paw of endothelin-1 (capsaicin-induced hindpaw licking time increased from 43 +/- 3 s to 114 +/- 7 s, n = 6), but no hyperalgesia was evident following 30 pmol/paw of endothelin-1.	Capsaicin	68-77	endothelin 1	Mus musculus	54-66
9698200-3	1998	Maximal hyperalgesia was obtained with 10 pmol/paw of endothelin-1 (capsaicin-induced hindpaw licking time increased from 43 +/- 3 s to 114 +/- 7 s, n = 6), but no hyperalgesia was evident following 30 pmol/paw of endothelin-1.	Capsaicin	68-77	endothelin 1	Mus musculus	214-226
9698200-9	1998	Therefore, local endothelin-1 exerts a dual influence in this model: at low doses it causes endothelin ET(A) receptor-mediated hyperalgesia (i.e., it potentiates capsaicin-induced nociception), whereas at higher doses it induces an anti-hyperalgesic effect against 5-HT which seems to be mediated via distinct endothelin ET (possibly ET(B)) receptors.	Capsaicin	162-171	endothelin 1	Mus musculus	17-29
9492062-3	1998	ET-1, ET-2, beta-ET, and S6b rapidly stimulated prostaglandin E2 production within 5 min, whereas ET-3, S6a, and S6c did not.	Dinoprostone	48-64	endothelin 1	Mus musculus	0-4
9492062-4	1998	ET-1, ET-2, beta-ET, S6b, and S6a induced prostaglandin synthesis after 3 h of incubation.	Prostaglandins	42-55	endothelin 1	Mus musculus	0-4
10392719-6	1998	The inhibition of this stimulation by the selective endothelin B receptor antagonist BQ-788 (N-cis-2,6-dimethylpiperidinocarbonyl-L-alpha-methylleucyl-D -1-methoxycarbonyltryptophanyl-D-norleucine) suggested that the three endothelins all signal through the endothelin B receptor.	BQ 788	85-91	endothelin 1	Mus musculus	223-234
9595487-7	1998	Immunoreactivity to ET-1 and ET-3 was preferentially localized in the rough endoplasmic reticulum and cytoplasmic vesicles of the ICs and along the plasma membrane of the ICs and in the MCs apposed to the ICs.	mcs	186-189	endothelin 1	Mus musculus	20-33
9595499-5	1998	ET-1 production was significantly increased in the heart of THM because both ET-1 mRNA expression and peptide levels were significantly higher than in controls.	Thymidine	60-63	endothelin 1	Mus musculus	0-4
9595537-5	1998	This LPS-induced upregulation of ET-1 and AM expression is greatly potentiated by D-galactosamine (D-GalN), although D-GalN alone could not induce ET-1 and AM gene expression.	Galactosamine	82-97	endothelin 1	Mus musculus	33-37
9595537-5	1998	This LPS-induced upregulation of ET-1 and AM expression is greatly potentiated by D-galactosamine (D-GalN), although D-GalN alone could not induce ET-1 and AM gene expression.	Galactosamine	82-97	endothelin 1	Mus musculus	33-44
9595542-0	1998	Systemic and renal response to salt loading in endothelin-1 knockout mice.	Salts	31-35	endothelin 1	Mus musculus	47-59
9595542-2	1998	In this study we examined responses to salt loading in ET-1 knockout mice to investigate whether ET-1 is involved in the pathophysiology of salt-sensitive hypertension.	Salts	140-144	endothelin 1	Mus musculus	97-101
9595542-6	1998	A high-salt diet caused a significant decrease in renal ET-1 levels by about 50% in both groups.	Salts	7-11	endothelin 1	Mus musculus	56-60
9595542-10	1998	We conclude that changes in ET-1 production within a physiologic range do not affect salt sensitivity, although renal ET-1 content is decreased by salt loading.	Salts	147-151	endothelin 1	Mus musculus	118-122
9595499-5	1998	ET-1 production was significantly increased in the heart of THM because both ET-1 mRNA expression and peptide levels were significantly higher than in controls.	Thymidine	60-63	endothelin 1	Mus musculus	77-81
9595543-2	1998	BQ-123 (10(-7) M) or BQ-788 (10(-7) M) abolished the vasoconstriction induced by ET-1 in the arterial mesenteric and renal vasculatures without affecting that of norepinephrine (NE).	cyclo(Trp-Asp-Pro-Val-Leu)	0-6	endothelin 1	Mus musculus	81-85
9595543-2	1998	BQ-123 (10(-7) M) or BQ-788 (10(-7) M) abolished the vasoconstriction induced by ET-1 in the arterial mesenteric and renal vasculatures without affecting that of norepinephrine (NE).	BQ 788	21-27	endothelin 1	Mus musculus	81-85
9267689-1	1997	We previously reported that endothelin-1 (ET-1) stimulates phosphatidylcholine-hydrolyzing phospholipase D independently of phosphoinositide hydrolysis in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	59-78	endothelin 1	Mus musculus	28-40
9595543-3	1998	In the venous mesenteric vasculature, only BQ-123 reduced the response to ET-1 but not to NE.	cyclo(Trp-Asp-Pro-Val-Leu)	43-49	endothelin 1	Mus musculus	74-78
9457649-11	1997	The ET-1-induced inhibition of JCl was prevented by protein kinase C inhibitors (staurosporine or GF 109203) and was reproduced by diacylglycerol analogues (OAG and DiC8).	Staurosporine	81-94	endothelin 1	Mus musculus	4-8
9457649-11	1997	The ET-1-induced inhibition of JCl was prevented by protein kinase C inhibitors (staurosporine or GF 109203) and was reproduced by diacylglycerol analogues (OAG and DiC8).	gf 109203	98-107	endothelin 1	Mus musculus	4-8
9457649-11	1997	The ET-1-induced inhibition of JCl was prevented by protein kinase C inhibitors (staurosporine or GF 109203) and was reproduced by diacylglycerol analogues (OAG and DiC8).	Diglycerides	131-145	endothelin 1	Mus musculus	4-8
9457649-11	1997	The ET-1-induced inhibition of JCl was prevented by protein kinase C inhibitors (staurosporine or GF 109203) and was reproduced by diacylglycerol analogues (OAG and DiC8).	1-oleoyl-2-acetylglycerol	157-160	endothelin 1	Mus musculus	4-8
9457649-11	1997	The ET-1-induced inhibition of JCl was prevented by protein kinase C inhibitors (staurosporine or GF 109203) and was reproduced by diacylglycerol analogues (OAG and DiC8).	1,2-dioctanoylglycerol	165-169	endothelin 1	Mus musculus	4-8
9350030-5	1997	Addition of ET-1 to the cells produced a concentration-dependent increase in intracellular calcium release.	Calcium	91-98	endothelin 1	Mus musculus	12-16
9357861-5	1997	Exposure of mice bearing the 2.5-kb PPET-1/LUC transgene to hypoxia (10% O2 for 24 h) increased LUC expression sixfold in pulmonary tissue but only twofold in other tissues.	Oxygen	73-75	endothelin 1	Mus musculus	36-42
9357861-7	1997	These data are consistent with the hypothesis that hypoxic induction of the PPET-1 gene leads to increased pulmonary production of ET-1 in diseases associated with low O2 tension.	Oxygen	168-170	endothelin 1	Mus musculus	76-82
9299470-4	1997	Appropriate application of 5-azacytidine enhanced these tendencies and induced slow contraction by endothelin-1 and phenylephrine.	Azacitidine	27-40	endothelin 1	Mus musculus	99-111
9267689-1	1997	We previously reported that endothelin-1 (ET-1) stimulates phosphatidylcholine-hydrolyzing phospholipase D independently of phosphoinositide hydrolysis in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	59-78	endothelin 1	Mus musculus	42-46
9267689-3	1997	Cyclo-D-Trp-D-Asp-Pro-D-Val-Leu (BQ123), a selective ETA receptor antagonist, significantly inhibited the ET-1-induced formation of inositol phosphates in a dose-dependent manner in the range between 22 nmol/L (IC50) and 2.2 mumol/L (IC50 x 100).	cyclo(Trp-Asp-Pro-Val-Leu)	0-31	endothelin 1	Mus musculus	106-110
9216943-6	1997	No dose of BQ-123 blocked ET-1-induced constriction, whereas pretreatment with each dose of BQ-788 significantly inhibited ET-1-induced responses.	BQ 788	92-98	endothelin 1	Mus musculus	123-127
9267689-3	1997	Cyclo-D-Trp-D-Asp-Pro-D-Val-Leu (BQ123), a selective ETA receptor antagonist, significantly inhibited the ET-1-induced formation of inositol phosphates in a dose-dependent manner in the range between 22 nmol/L (IC50) and 2.2 mumol/L (IC50 x 100).	cyclo(Trp-Asp-Pro-Val-Leu)	33-38	endothelin 1	Mus musculus	106-110
9267689-3	1997	Cyclo-D-Trp-D-Asp-Pro-D-Val-Leu (BQ123), a selective ETA receptor antagonist, significantly inhibited the ET-1-induced formation of inositol phosphates in a dose-dependent manner in the range between 22 nmol/L (IC50) and 2.2 mumol/L (IC50 x 100).	Inositol Phosphates	132-151	endothelin 1	Mus musculus	106-110
9267689-4	1997	On the contrary, N-cis-2,6-dimethylpiperidinocarbonyl-L-gamma MeLeu-D-Trp(COOMe)-D-Nle-ONa (BQ788), a selective ETB receptor antagonist, had no effect on the ET-1-induced formation of inositol phosphates in the range between 1.2 nmol/L (IC50) and 120 nmol/L (IC50 x 100).	-d-trp	67-73	endothelin 1	Mus musculus	158-162
9267689-4	1997	On the contrary, N-cis-2,6-dimethylpiperidinocarbonyl-L-gamma MeLeu-D-Trp(COOMe)-D-Nle-ONa (BQ788), a selective ETB receptor antagonist, had no effect on the ET-1-induced formation of inositol phosphates in the range between 1.2 nmol/L (IC50) and 120 nmol/L (IC50 x 100).	BQ 788	92-97	endothelin 1	Mus musculus	158-162
9267689-5	1997	BQ123 significantly suppressed the ET-1-induced formation of choline dose-dependently, however, BQ788 did not affect the choline formation.	cyclo(Trp-Asp-Pro-Val-Leu)	0-5	endothelin 1	Mus musculus	35-39
9267689-5	1997	BQ123 significantly suppressed the ET-1-induced formation of choline dose-dependently, however, BQ788 did not affect the choline formation.	Choline	61-68	endothelin 1	Mus musculus	35-39
9267689-6	1997	BQ123 also inhibited the ET-1-induced release of arachidonic acid, but BQ788 had little effect.	cyclo(Trp-Asp-Pro-Val-Leu)	0-5	endothelin 1	Mus musculus	25-29
9267689-6	1997	BQ123 also inhibited the ET-1-induced release of arachidonic acid, but BQ788 had little effect.	Arachidonic Acid	49-65	endothelin 1	Mus musculus	25-29
9267689-7	1997	The results strongly suggest that ETA receptor mediates the three intracellular signaling pathways of ET-1: (1) phosphoinositide hydrolysis by phospholipase C; (2) phosphatidylcholine hydrolysis by phospholipase D; (3) arachidonic acid release in osteoblast-like cells.	Phosphatidylinositols	112-128	endothelin 1	Mus musculus	102-106
9267689-7	1997	The results strongly suggest that ETA receptor mediates the three intracellular signaling pathways of ET-1: (1) phosphoinositide hydrolysis by phospholipase C; (2) phosphatidylcholine hydrolysis by phospholipase D; (3) arachidonic acid release in osteoblast-like cells.	Phosphatidylcholines	164-183	endothelin 1	Mus musculus	102-106
9267689-7	1997	The results strongly suggest that ETA receptor mediates the three intracellular signaling pathways of ET-1: (1) phosphoinositide hydrolysis by phospholipase C; (2) phosphatidylcholine hydrolysis by phospholipase D; (3) arachidonic acid release in osteoblast-like cells.	Arachidonic Acid	219-235	endothelin 1	Mus musculus	102-106
9416772-0	1997	Selective and non-selective ET antagonists reveal an ET(A)/ET(B) receptor mediated ET-1-induced antinociceptive effect in PAG area of mice.	pag	122-125	endothelin 1	Mus musculus	83-87
9276135-0	1997	Endothelins potentiate formalin-induced nociception and paw edema in mice.	Formaldehyde	23-31	endothelin 1	Mus musculus	0-11
9276135-2	1997	The first phase of nociception (0-5 min after injection) was significantly potentiated by simultaneous injection of either ET-1 (10 or 30 pmol/paw) or ET-3 (10 pmol/paw), but not of the selective ET3 receptor agonist sarafotoxin S6c (SRTX-c; up to 30 pmol/paw).	sarafotoxin	217-228	endothelin 1	Mus musculus	123-127
9276135-2	1997	The first phase of nociception (0-5 min after injection) was significantly potentiated by simultaneous injection of either ET-1 (10 or 30 pmol/paw) or ET-3 (10 pmol/paw), but not of the selective ET3 receptor agonist sarafotoxin S6c (SRTX-c; up to 30 pmol/paw).	s6c	229-232	endothelin 1	Mus musculus	123-127
9276135-3	1997	All three peptides potentiated the second phase (10-30 min after injection) of formalin-induced nociception (at 3-30, 1-30, and 10-30 pmol/paw for ET-1, ET-3, and SRTX-c, respectively), whereas only ET-1 (10 or 30 pmol/paw) effectively enhanced edema caused by formalin (30 min after injection).	Formaldehyde	79-87	endothelin 1	Mus musculus	199-203
9276135-6	1997	Thus, ET-1 potentiates formalin-induced nociception and edema in the mouse.	Formaldehyde	23-31	endothelin 1	Mus musculus	6-10
9057095-0	1997	Involvement of phospholipase D activation in endothelin-1-induced release of arachidonic acid in osteoblast-like cells.	Arachidonic Acid	77-93	endothelin 1	Mus musculus	45-57
9057095-3	1997	In the present study, we investigated the role of phospholipase D activation in ET-1 stimulated arachidonic acid release and prostaglandin E2 (PGE2) synthesis in osteoblast-like MC3T3-E1 cells.	Arachidonic Acid	96-112	endothelin 1	Mus musculus	80-84
9057095-3	1997	In the present study, we investigated the role of phospholipase D activation in ET-1 stimulated arachidonic acid release and prostaglandin E2 (PGE2) synthesis in osteoblast-like MC3T3-E1 cells.	Dinoprostone	125-141	endothelin 1	Mus musculus	80-84
9057095-4	1997	ET-1 stimulated arachidonic acid dose-dependently in the range between 0.1 nM and 0.1 microM.	Arachidonic Acid	16-32	endothelin 1	Mus musculus	0-4
9057095-5	1997	Propranolol, an inhibitor of phosphatidic acid phosphohydrolase, significantly inhibited the ET-1-induced arachidonic acid release in a dose-dependent manner as well as the ET-1-induced diacylglycerol formation.	Propranolol	0-11	endothelin 1	Mus musculus	93-97
9057095-5	1997	Propranolol, an inhibitor of phosphatidic acid phosphohydrolase, significantly inhibited the ET-1-induced arachidonic acid release in a dose-dependent manner as well as the ET-1-induced diacylglycerol formation.	Propranolol	0-11	endothelin 1	Mus musculus	173-177
9057095-5	1997	Propranolol, an inhibitor of phosphatidic acid phosphohydrolase, significantly inhibited the ET-1-induced arachidonic acid release in a dose-dependent manner as well as the ET-1-induced diacylglycerol formation.	Arachidonic Acid	106-122	endothelin 1	Mus musculus	93-97
9057095-5	1997	Propranolol, an inhibitor of phosphatidic acid phosphohydrolase, significantly inhibited the ET-1-induced arachidonic acid release in a dose-dependent manner as well as the ET-1-induced diacylglycerol formation.	Diglycerides	186-200	endothelin 1	Mus musculus	173-177
9057095-6	1997	1,6-bis-(cyclohexyloxyminocarbonylamino)-hexane (RHC-80267), an inhibitor of diacylglycerol lipase, significantly suppressed the ET-1-induced arachidonic acid release.	1,6-bis-(cyclohexyloxyminocarbonylamino)-hexane	0-47	endothelin 1	Mus musculus	129-133
9057095-6	1997	1,6-bis-(cyclohexyloxyminocarbonylamino)-hexane (RHC-80267), an inhibitor of diacylglycerol lipase, significantly suppressed the ET-1-induced arachidonic acid release.	1,6-bis(cyclohexyloximinocarbonyl)hexane	49-58	endothelin 1	Mus musculus	129-133
9057095-6	1997	1,6-bis-(cyclohexyloxyminocarbonylamino)-hexane (RHC-80267), an inhibitor of diacylglycerol lipase, significantly suppressed the ET-1-induced arachidonic acid release.	Arachidonic Acid	142-158	endothelin 1	Mus musculus	129-133
9057095-7	1997	The pretreatment with propranolol and RHC-80267 also inhibited the ET-1-induced PGE2 synthesis.	Propranolol	22-33	endothelin 1	Mus musculus	67-71
9057095-7	1997	The pretreatment with propranolol and RHC-80267 also inhibited the ET-1-induced PGE2 synthesis.	Dinoprostone	80-84	endothelin 1	Mus musculus	67-71
9057095-8	1997	These results strongly suggest that phosphatidylcholine hydrolysis by phospholipase D is involved in the arachidonic acid release induced by ET-1 in osteoblast-like cells.	Phosphatidylcholines	36-55	endothelin 1	Mus musculus	141-145
9057095-8	1997	These results strongly suggest that phosphatidylcholine hydrolysis by phospholipase D is involved in the arachidonic acid release induced by ET-1 in osteoblast-like cells.	Arachidonic Acid	105-121	endothelin 1	Mus musculus	141-145
9416772-1	1997	The injection of endothelin-1 (ET-1) (2 pmol) into the dorsolateral periaqueductal gray area (PAG) of mice produces antinociceptive effect as underscored by increases in the latency time for the reaction to a hot plate.	pag	94-97	endothelin 1	Mus musculus	17-29
9416772-1	1997	The injection of endothelin-1 (ET-1) (2 pmol) into the dorsolateral periaqueductal gray area (PAG) of mice produces antinociceptive effect as underscored by increases in the latency time for the reaction to a hot plate.	pag	94-97	endothelin 1	Mus musculus	31-35
9416772-4	1997	In addition, since ET-antagonists lowered per se the control reaction time of the mice when administered alone to the PAG area, we would suggest that endogenous ET-1 acting within the PAG area contributes to the suppression of pain.	pag	118-121	endothelin 1	Mus musculus	161-165
9416772-4	1997	In addition, since ET-antagonists lowered per se the control reaction time of the mice when administered alone to the PAG area, we would suggest that endogenous ET-1 acting within the PAG area contributes to the suppression of pain.	pag	184-187	endothelin 1	Mus musculus	161-165
8978503-4	1996	ET-1, ET-2, and ET-3 were equipotent in suppressing the CNP-induced cGMP response, suggesting that this effect was mediated by ETB receptors.	Cyclic GMP	68-72	endothelin 1	Mus musculus	0-4
8886411-19	1996	In contrast, in tissues taken from virus-infected mice at day 4 post-inoculation, BQ-123 caused a marked 9.6 fold rightward shift in the concentration-effect curve to endothelin-1 (n = 4).	cyclo(Trp-Asp-Pro-Val-Leu)	82-88	endothelin 1	Mus musculus	167-179
8877285-11	1996	In addition, ET-1 transiently enhanced 86Rb(+)-efflux from 86Rb(+)-prelabelled islets both in the presence (p &lt; 0.001) and in the absence (p &lt; 0.001) of extracellular Ca2+ suggesting that ET-1 does not elicit insulin secretion by inhibition of the potassium permeability.	Rubidium-86	39-46	endothelin 1	Mus musculus	194-198
8877285-11	1996	In addition, ET-1 transiently enhanced 86Rb(+)-efflux from 86Rb(+)-prelabelled islets both in the presence (p &lt; 0.001) and in the absence (p &lt; 0.001) of extracellular Ca2+ suggesting that ET-1 does not elicit insulin secretion by inhibition of the potassium permeability.	Potassium	254-263	endothelin 1	Mus musculus	13-17
8922737-15	1996	Endothelin-1 (1 nM) caused similar potentiations of standard EFS-induced contractions in tracheal segments from control (13 +/- 2% Cmax, n = 23) and virus-inoculated mice at day 2 (13 +/- 1% Cmax, n = 5), day 4 (16 +/- 5% Cmax, n = 6), and day 8 (13 +/- 3% Cmax, n = 8) post-inoculation.	cmax	131-135	endothelin 1	Mus musculus	0-12
8922737-15	1996	Endothelin-1 (1 nM) caused similar potentiations of standard EFS-induced contractions in tracheal segments from control (13 +/- 2% Cmax, n = 23) and virus-inoculated mice at day 2 (13 +/- 1% Cmax, n = 5), day 4 (16 +/- 5% Cmax, n = 6), and day 8 (13 +/- 3% Cmax, n = 8) post-inoculation.	cmax	191-195	endothelin 1	Mus musculus	0-12
8922737-18	1996	However, simultaneous pre-incubation with BQ-123 (3 microM) and BQ-788 (1 microM) prevented endothelin-1-evoked potentiations, indicative of a role for both ETA and ETB receptors in this system.	cyclo(Trp-Asp-Pro-Val-Leu)	42-48	endothelin 1	Mus musculus	92-104
8922737-18	1996	However, simultaneous pre-incubation with BQ-123 (3 microM) and BQ-788 (1 microM) prevented endothelin-1-evoked potentiations, indicative of a role for both ETA and ETB receptors in this system.	BQ 788	64-70	endothelin 1	Mus musculus	92-104
8877285-5	1996	ET-1 (1 nmol/l-1 mumol/l) dose-dependently stimulated insulin secretion from islets incubated in the presence of 16.7 mmol/l glucose (p &lt; 0.05).	Glucose	125-132	endothelin 1	Mus musculus	0-4
8877285-6	1996	The effect of ET-1 is glucose-dependent since no potentiation was found at 3.3 mmol/l glucose.	Glucose	22-29	endothelin 1	Mus musculus	14-18
8877285-6	1996	The effect of ET-1 is glucose-dependent since no potentiation was found at 3.3 mmol/l glucose.	Glucose	86-93	endothelin 1	Mus musculus	14-18
8877285-7	1996	Furthermore, ET-1 induced a large, transient increase in glucose-stimulated insulin secretion during islet perifusion in the presence (p &lt; 0.001), but not in the absence, of extracellular Ca2+.	Glucose	57-64	endothelin 1	Mus musculus	13-17
8877285-8	1996	The rate of 45Ca(2+)-efflux from 45Ca(2+)-prelabelled islets was transiently stimulated by ET-1 during perifusion at 16.7 mmol/l glucose in the presence of extracellular Ca2+ (p &lt; 0.001).	Glucose	129-136	endothelin 1	Mus musculus	91-95
8877285-11	1996	In addition, ET-1 transiently enhanced 86Rb(+)-efflux from 86Rb(+)-prelabelled islets both in the presence (p &lt; 0.001) and in the absence (p &lt; 0.001) of extracellular Ca2+ suggesting that ET-1 does not elicit insulin secretion by inhibition of the potassium permeability.	Rubidium-86	39-46	endothelin 1	Mus musculus	13-17
8807579-1	1996	We have recently described that endothelins-1 to -3 equipotently inhibit cAMP stimulated renin secretion from cultured mouse juxtaglomerular cells by a process involving phospholipase C activation.	Cyclic AMP	73-77	endothelin 1	Mus musculus	32-51
8770164-2	1996	It has been suggested that medullary ET-1 may affect water and sodium absorption along the collecting ducts in an autocrine fashion.	Water	53-58	endothelin 1	Mus musculus	37-41
8770164-2	1996	It has been suggested that medullary ET-1 may affect water and sodium absorption along the collecting ducts in an autocrine fashion.	Sodium	63-69	endothelin 1	Mus musculus	37-41
8635230-2	1996	Endothelin-1 (endothelin) stimulates phosphoinositide hydrolysis in a dose-dependent manner.	Phosphatidylinositols	37-53	endothelin 1	Mus musculus	0-12
8635230-7	1996	This is blocked by both phorbol 12-myristate 13-acetate (PMA) pretreatment to downregulate PKC and the PKC inhibitor chelerythrine, arguing that PKCepsilon plays a critical role in endothelin receptor-dependent increases in intracellular calcium.	chelerythrine	117-130	endothelin 1	Mus musculus	181-191
8635230-7	1996	This is blocked by both phorbol 12-myristate 13-acetate (PMA) pretreatment to downregulate PKC and the PKC inhibitor chelerythrine, arguing that PKCepsilon plays a critical role in endothelin receptor-dependent increases in intracellular calcium.	Calcium	238-245	endothelin 1	Mus musculus	181-191
8635230-12	1996	Thus, these studies identify a functional role for PKCepsilon as a mediator of endothelin receptor-dependent increases in cytosolic calcium and MAPK activity in AT-1 cells.	Calcium	132-139	endothelin 1	Mus musculus	79-89
8826508-5	1996	Prazosin, an alpha 1-adrenergic blocking agent, also prevented the ET-1 antinociceptive effect.	Prazosin	0-8	endothelin 1	Mus musculus	67-71
8882619-9	1996	Endothelin-1 was a potent spasmogen in isolated tracheal airway smooth muscle preparations from control mice (ED70 = concentration producing 70% of contraction induced by 10 microM carbachol = 6.3 nM (95% confidence limits, 4.0-10; n = 6 mice)).	Carbachol	181-190	endothelin 1	Mus musculus	0-12
8882619-11	1996	However, simultaneous treatment with BQ-123 (3 microM) and BQ-788 (1 microM) resulted in a 10 fold rightward shift in the concentration-effect curve to endothelin-1 (ED70 = 60 nM, (44-90; n = 6 mice, P &lt; 0.05)), indicating that contraction was mediated via both ETA and ETB receptors.	cyclo(Trp-Asp-Pro-Val-Leu)	37-43	endothelin 1	Mus musculus	152-164
8882619-11	1996	However, simultaneous treatment with BQ-123 (3 microM) and BQ-788 (1 microM) resulted in a 10 fold rightward shift in the concentration-effect curve to endothelin-1 (ED70 = 60 nM, (44-90; n = 6 mice, P &lt; 0.05)), indicating that contraction was mediated via both ETA and ETB receptors.	BQ 788	59-65	endothelin 1	Mus musculus	152-164
8882619-14	1996	In the presence of the ETB receptor-selective-antagonist, BQ-788 (1 microM), the potency and maximum response to endothelin-1 were similar in preparations from control and virus-inoculated mice at all time points investigated.	BQ 788	58-64	endothelin 1	Mus musculus	113-125
8882619-15	1996	However, unlike control responses, endothelin-1-induced contractions in preparations from virus-infected mice were significantly inhibited by the ETA receptor-selective antagonist, BQ-123.	cyclo(Trp-Asp-Pro-Val-Leu)	181-187	endothelin 1	Mus musculus	35-47
8882619-16	1996	For example, at day 4 post-inoculation, the contractile response to 30 nM endothelin-1, in the presence of BQ-123 (3 microM), was only 20 +/- 12% (n = 6 mice, P &lt; 0.05) of that produced in control preparations under similar conditions.	cyclo(Trp-Asp-Pro-Val-Leu)	107-113	endothelin 1	Mus musculus	74-86
8882619-17	1996	However, at day 19 post-inoculation, contraction evoked by 30 nM endothelin-1 in the presence of BQ-123 (3 microM), was similar to that in preparations from control mice.	cyclo(Trp-Asp-Pro-Val-Leu)	97-103	endothelin 1	Mus musculus	65-77
8603696-0	1996	Streptozotocin, an inducer of NAD+ decrease, attenuates M-potassium current inhibition by ATP, bradykinin, angiotensin II, endothelin 1 and acetylcholine in NG108-15 cells.	Streptozocin	0-14	endothelin 1	Mus musculus	123-135
8603696-0	1996	Streptozotocin, an inducer of NAD+ decrease, attenuates M-potassium current inhibition by ATP, bradykinin, angiotensin II, endothelin 1 and acetylcholine in NG108-15 cells.	NAD	30-34	endothelin 1	Mus musculus	123-135
8603696-0	1996	Streptozotocin, an inducer of NAD+ decrease, attenuates M-potassium current inhibition by ATP, bradykinin, angiotensin II, endothelin 1 and acetylcholine in NG108-15 cells.	Potassium	58-67	endothelin 1	Mus musculus	123-135
8603696-1	1996	The M-potassium current was inhibited by bath application of 100 micron ATP, 10 nM bradykinin, 100 nM angiotensin II and 100 nM endothelin 1 as well as by 10 micron acetylcholine in an m1-muscarinic acetylcholine receptor-transformed NG108-15 cell line.	Potassium	6-15	endothelin 1	Mus musculus	128-140
8635230-2	1996	Endothelin-1 (endothelin) stimulates phosphoinositide hydrolysis in a dose-dependent manner.	Phosphatidylinositols	37-53	endothelin 1	Mus musculus	14-24
8635230-5	1996	Using quantitative fluorescence microscopy with fura 2, we examined the effects of endothelin on intracellular calcium.	Calcium	111-118	endothelin 1	Mus musculus	83-93
8635230-6	1996	In electrically driven myocytes, endothelin induces a rapid and transient increase in the amplitude of the calcium transient.	Calcium	107-114	endothelin 1	Mus musculus	33-43
8635230-7	1996	This is blocked by both phorbol 12-myristate 13-acetate (PMA) pretreatment to downregulate PKC and the PKC inhibitor chelerythrine, arguing that PKCepsilon plays a critical role in endothelin receptor-dependent increases in intracellular calcium.	Tetradecanoylphorbol Acetate	24-55	endothelin 1	Mus musculus	181-191
8635230-7	1996	This is blocked by both phorbol 12-myristate 13-acetate (PMA) pretreatment to downregulate PKC and the PKC inhibitor chelerythrine, arguing that PKCepsilon plays a critical role in endothelin receptor-dependent increases in intracellular calcium.	Tetradecanoylphorbol Acetate	57-60	endothelin 1	Mus musculus	181-191
8531124-2	1995	In vitro, L-754,142 is a potent antagonist of ET-1-induced phosphatidyl inositol hydrolysis in Chinese hamster ovary cells expressing cloned human endothelin receptors (IC50: hETA = 0.35 nM; hETB = 26 nM) and of ET-1 induced contractions in rabbit iliac artery rings (pA2 = 7.74) and rat aortic rings (pA2 = 8.7).	l-754	10-15	endothelin 1	Mus musculus	46-50
8531124-3	1995	In vivo, L-754,142 is a potent and specific antagonist of exogenously administered ET-1 or big ET-1, L-754,142 fully protects against ET-1-induced lethality in mice (AD50 = 0.26 mg/kg i.v.).	l-754	9-14	endothelin 1	Mus musculus	83-87
8531124-2	1995	In vitro, L-754,142 is a potent antagonist of ET-1-induced phosphatidyl inositol hydrolysis in Chinese hamster ovary cells expressing cloned human endothelin receptors (IC50: hETA = 0.35 nM; hETB = 26 nM) and of ET-1 induced contractions in rabbit iliac artery rings (pA2 = 7.74) and rat aortic rings (pA2 = 8.7).	Phosphatidylinositols	59-80	endothelin 1	Mus musculus	46-50
8531124-3	1995	In vivo, L-754,142 is a potent and specific antagonist of exogenously administered ET-1 or big ET-1, L-754,142 fully protects against ET-1-induced lethality in mice (AD50 = 0.26 mg/kg i.v.).	l-754	9-14	endothelin 1	Mus musculus	95-99
8531124-3	1995	In vivo, L-754,142 is a potent and specific antagonist of exogenously administered ET-1 or big ET-1, L-754,142 fully protects against ET-1-induced lethality in mice (AD50 = 0.26 mg/kg i.v.).	l-754	9-14	endothelin 1	Mus musculus	95-99
8577203-5	1995	ET-1 and ET-3 produced central depressive effects demonstrated by depressive behavior signs, decrease of the spontaneous and amphetamine-stimulated motor activity, and prolongation of the hexobarbital-induced narcosis.	Hexobarbital	188-200	endothelin 1	Mus musculus	0-4
8577203-5	1995	ET-1 and ET-3 produced central depressive effects demonstrated by depressive behavior signs, decrease of the spontaneous and amphetamine-stimulated motor activity, and prolongation of the hexobarbital-induced narcosis.	Amphetamine	125-136	endothelin 1	Mus musculus	0-4
7781681-7	1995	In contrast, at 100, 300 nM and 1 microM, BQ-123 shifted the curve to endothelin-1 to the right only 2-, 5- and 6-fold, respectively.	cyclo(Trp-Asp-Pro-Val-Leu)	42-48	endothelin 1	Mus musculus	70-82
7781681-10	1995	Preincubation with phosphoramidon (100 microM) reduced responses to big-endothelin-1, but not endothelin-1.	phosphoramidon	19-33	endothelin 1	Mus musculus	72-84
7530742-8	1995	In BMMC, the histamine and serotonin release induced by ET-1 (10(-6) M) was inhibited by an ETA-R-specific antagonist (cyclic [D-Asp-Pro-D-Val-Leu-D-Trp]) in a dose-dependent manner, with complete inhibition at an antagonist concentration of 10(-8) M. ET-1 stimulated leukotriene C4 biosynthesis up to 4.5-fold in BMMC cultured in the presence of IL-4.	bmmc	3-7	endothelin 1	Mus musculus	252-256
7530742-4	1995	ET-1 induced a very rapid (&lt; or = 1 min) and dose-dependent release of histamine and serotonin from BMMC cultured in the presence of both IL-3 and IL-4.	Histamine	74-83	endothelin 1	Mus musculus	0-4
7530742-4	1995	ET-1 induced a very rapid (&lt; or = 1 min) and dose-dependent release of histamine and serotonin from BMMC cultured in the presence of both IL-3 and IL-4.	Serotonin	88-97	endothelin 1	Mus musculus	0-4
7530742-5	1995	The effect of ET-1 was quantitatively comparable with IgE/Ag-induced mediator release and comprised up to 20% and 16% of total cellular histamine and serotonin, respectively.	Histamine	136-145	endothelin 1	Mus musculus	14-18
7530742-5	1995	The effect of ET-1 was quantitatively comparable with IgE/Ag-induced mediator release and comprised up to 20% and 16% of total cellular histamine and serotonin, respectively.	Serotonin	150-159	endothelin 1	Mus musculus	14-18
7530742-6	1995	In BMMC grown with KL or KL plus IL-3, a substantial effect of ET-1 on amine release was only observed when IL-4 had been included in the culture medium.	Amines	71-76	endothelin 1	Mus musculus	63-67
7530742-8	1995	In BMMC, the histamine and serotonin release induced by ET-1 (10(-6) M) was inhibited by an ETA-R-specific antagonist (cyclic [D-Asp-Pro-D-Val-Leu-D-Trp]) in a dose-dependent manner, with complete inhibition at an antagonist concentration of 10(-8) M. ET-1 stimulated leukotriene C4 biosynthesis up to 4.5-fold in BMMC cultured in the presence of IL-4.	bmmc	3-7	endothelin 1	Mus musculus	56-60
7530742-8	1995	In BMMC, the histamine and serotonin release induced by ET-1 (10(-6) M) was inhibited by an ETA-R-specific antagonist (cyclic [D-Asp-Pro-D-Val-Leu-D-Trp]) in a dose-dependent manner, with complete inhibition at an antagonist concentration of 10(-8) M. ET-1 stimulated leukotriene C4 biosynthesis up to 4.5-fold in BMMC cultured in the presence of IL-4.	Histamine	13-22	endothelin 1	Mus musculus	56-60
7530742-8	1995	In BMMC, the histamine and serotonin release induced by ET-1 (10(-6) M) was inhibited by an ETA-R-specific antagonist (cyclic [D-Asp-Pro-D-Val-Leu-D-Trp]) in a dose-dependent manner, with complete inhibition at an antagonist concentration of 10(-8) M. ET-1 stimulated leukotriene C4 biosynthesis up to 4.5-fold in BMMC cultured in the presence of IL-4.	Histamine	13-22	endothelin 1	Mus musculus	252-256
7530742-8	1995	In BMMC, the histamine and serotonin release induced by ET-1 (10(-6) M) was inhibited by an ETA-R-specific antagonist (cyclic [D-Asp-Pro-D-Val-Leu-D-Trp]) in a dose-dependent manner, with complete inhibition at an antagonist concentration of 10(-8) M. ET-1 stimulated leukotriene C4 biosynthesis up to 4.5-fold in BMMC cultured in the presence of IL-4.	Serotonin	27-36	endothelin 1	Mus musculus	56-60
7530742-8	1995	In BMMC, the histamine and serotonin release induced by ET-1 (10(-6) M) was inhibited by an ETA-R-specific antagonist (cyclic [D-Asp-Pro-D-Val-Leu-D-Trp]) in a dose-dependent manner, with complete inhibition at an antagonist concentration of 10(-8) M. ET-1 stimulated leukotriene C4 biosynthesis up to 4.5-fold in BMMC cultured in the presence of IL-4.	Serotonin	27-36	endothelin 1	Mus musculus	252-256
7530742-8	1995	In BMMC, the histamine and serotonin release induced by ET-1 (10(-6) M) was inhibited by an ETA-R-specific antagonist (cyclic [D-Asp-Pro-D-Val-Leu-D-Trp]) in a dose-dependent manner, with complete inhibition at an antagonist concentration of 10(-8) M. ET-1 stimulated leukotriene C4 biosynthesis up to 4.5-fold in BMMC cultured in the presence of IL-4.	cyclic [d-asp-pro-d-val-leu-d-trp	119-152	endothelin 1	Mus musculus	56-60
7530742-8	1995	In BMMC, the histamine and serotonin release induced by ET-1 (10(-6) M) was inhibited by an ETA-R-specific antagonist (cyclic [D-Asp-Pro-D-Val-Leu-D-Trp]) in a dose-dependent manner, with complete inhibition at an antagonist concentration of 10(-8) M. ET-1 stimulated leukotriene C4 biosynthesis up to 4.5-fold in BMMC cultured in the presence of IL-4.	cyclic [d-asp-pro-d-val-leu-d-trp	119-152	endothelin 1	Mus musculus	252-256
7530742-8	1995	In BMMC, the histamine and serotonin release induced by ET-1 (10(-6) M) was inhibited by an ETA-R-specific antagonist (cyclic [D-Asp-Pro-D-Val-Leu-D-Trp]) in a dose-dependent manner, with complete inhibition at an antagonist concentration of 10(-8) M. ET-1 stimulated leukotriene C4 biosynthesis up to 4.5-fold in BMMC cultured in the presence of IL-4.	Leukotrienes	268-279	endothelin 1	Mus musculus	56-60
7530742-10	1995	Peritoneal cells (containing 2 to 3% serosal mast cells) obtained from BALB/c mice released 87 +/- 2% of histamine within 1 min after challenge with ET-1.	Histamine	105-114	endothelin 1	Mus musculus	149-153
7530742-11	1995	Our results demonstrate that ET-1 can directly act as a histamine and serotonin secretagogue and as a stimulator of leukotriene C4 production in mast cells.	Histamine	56-65	endothelin 1	Mus musculus	29-33
7530742-11	1995	Our results demonstrate that ET-1 can directly act as a histamine and serotonin secretagogue and as a stimulator of leukotriene C4 production in mast cells.	Serotonin	70-79	endothelin 1	Mus musculus	29-33
7530742-11	1995	Our results demonstrate that ET-1 can directly act as a histamine and serotonin secretagogue and as a stimulator of leukotriene C4 production in mast cells.	Leukotriene C4	116-130	endothelin 1	Mus musculus	29-33
7952880-13	1994	Endothelin-1-induced contractions in control preparations were only marginally inhibited by the ETA receptor-selective antagonist BQ-123 (in the presence of 3 micro M BQ-123; EC50 for contraction, 5.9 nM [4.1-8.5]; maximum contraction, 82 +/- 4%Cmax; n = 4).	cyclo(Trp-Asp-Pro-Val-Leu)	130-136	endothelin 1	Mus musculus	0-12
7735683-14	1995	At 0.1 nM, endothelin-1 exerted no direct contractile effect, but significantly increased the standard EFS-induced contraction of 20%Cmax, by 7 +/- 2%Cma, (i.e. 1.35 fold, n = 5, P&lt;0.05).	cmax	133-137	endothelin 1	Mus musculus	11-23
7859925-1	1994	We examined the effect of endothelin-1 (ET-1) on phosphatidylcholine-hydrolyzing phospholipase D activity in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	49-68	endothelin 1	Mus musculus	26-38
7859925-1	1994	We examined the effect of endothelin-1 (ET-1) on phosphatidylcholine-hydrolyzing phospholipase D activity in osteoblast-like MC3T3-E1 cells.	Phosphatidylcholines	49-68	endothelin 1	Mus musculus	40-44
7859925-2	1994	ET-1 stimulated the formation of choline (EC50 10 nM) as well as that of inositol phosphates (EC50 1.2 nM).	Choline	33-40	endothelin 1	Mus musculus	0-4
7859925-2	1994	ET-1 stimulated the formation of choline (EC50 10 nM) as well as that of inositol phosphates (EC50 1.2 nM).	Inositol Phosphates	73-92	endothelin 1	Mus musculus	0-4
7859925-4	1994	Staurosporine enhanced the ET-1-induced formation of choline.	Staurosporine	0-13	endothelin 1	Mus musculus	27-31
7859925-4	1994	Staurosporine enhanced the ET-1-induced formation of choline.	Choline	53-60	endothelin 1	Mus musculus	27-31
7539768-0	1995	Mechanism of histamine release by endothelin-1 distinct from that by antigen in mouse bone marrow-derived mast cells.	Histamine	13-22	endothelin 1	Mus musculus	34-46
7539768-1	1995	The mechanisms of endothelin-1-induced histamine release were examined and compared with those responsible for antigen-induced release by using passively sensitized mouse bone marrow-derived mast cells and various drugs that may influence histamine release.	Histamine	39-48	endothelin 1	Mus musculus	18-30
7539768-2	1995	The following results were obtained: (1) Although islet-activating protein potently inhibited endothelin-1-induced histamine release, it did not affect the antigen-induced release.	Histamine	115-124	endothelin 1	Mus musculus	94-106
7539768-3	1995	(2) Histamine release induced by endothelin-1 was relatively more sensitive to ethylenediaminetetraacetic acid than that induced by antigen, although extracellular Ca2+ is a requisite for both types of the release.	Histamine	4-13	endothelin 1	Mus musculus	33-45
7539768-3	1995	(2) Histamine release induced by endothelin-1 was relatively more sensitive to ethylenediaminetetraacetic acid than that induced by antigen, although extracellular Ca2+ is a requisite for both types of the release.	Edetic Acid	79-110	endothelin 1	Mus musculus	33-45
7539768-6	1995	These results indicate and/or suggest that some biological events induced by endothelin-1 leading to histamine release are different from those involved in the histamine release induced by antigen.	Histamine	101-110	endothelin 1	Mus musculus	77-89
7533727-0	1994	Endothelin-1, one of the most potent histamine releasers in mouse peritoneal mast cells.	Histamine	37-46	endothelin 1	Mus musculus	0-12
7533727-1	1994	Whether endothelin-1 or -3 is capable of inducing histamine release from the peritoneal mast cells of BALB/c mice was investigated in vitro and compared to the release induced by compound 48/80.	Histamine	50-59	endothelin 1	Mus musculus	8-26
7533727-2	1994	In contrast to the mouse bone marrow-derived mast cells, which originated from the same strain and have been reported upon previously, the (both crude and purified) peritoneal mast cells potently secreted histamine in response to either endothelin-1 or endothelin-3 in a concentration-dependent fashion.	Histamine	205-214	endothelin 1	Mus musculus	237-249
7533727-3	1994	Even at a concentration as low as 10 nM, endothelin-1 induced a histamine release of more than 50% from the peritoneal mast cells.	Histamine	64-73	endothelin 1	Mus musculus	41-53
7533727-4	1994	Cyclo(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123), an endothelin ETA receptor antagonist, markedly suppressed not only the histamine released induced by endothelin-1 but also that due to endothelin-3 at a similarly low concentration range.	emodepside	0-5	endothelin 1	Mus musculus	145-157
7533727-4	1994	Cyclo(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123), an endothelin ETA receptor antagonist, markedly suppressed not only the histamine released induced by endothelin-1 but also that due to endothelin-3 at a similarly low concentration range.	d-asp-pro-d-val-leu-d-trp	6-31	endothelin 1	Mus musculus	145-157
7533727-4	1994	Cyclo(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123), an endothelin ETA receptor antagonist, markedly suppressed not only the histamine released induced by endothelin-1 but also that due to endothelin-3 at a similarly low concentration range.	cyclo(Trp-Asp-Pro-Val-Leu)	34-40	endothelin 1	Mus musculus	145-157
7533727-4	1994	Cyclo(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123), an endothelin ETA receptor antagonist, markedly suppressed not only the histamine released induced by endothelin-1 but also that due to endothelin-3 at a similarly low concentration range.	Histamine	115-124	endothelin 1	Mus musculus	145-157
7533727-5	1994	Treatment with islet-activating protein (IAP) for 3 h, an inactivator of guanosine triphosphate (GTP) (Gi)-protein, markedly reduced the histamine release induced by endothelin-1.	Guanosine Triphosphate	73-95	endothelin 1	Mus musculus	166-178
7533727-5	1994	Treatment with islet-activating protein (IAP) for 3 h, an inactivator of guanosine triphosphate (GTP) (Gi)-protein, markedly reduced the histamine release induced by endothelin-1.	Guanosine Triphosphate	97-100	endothelin 1	Mus musculus	166-178
7533727-5	1994	Treatment with islet-activating protein (IAP) for 3 h, an inactivator of guanosine triphosphate (GTP) (Gi)-protein, markedly reduced the histamine release induced by endothelin-1.	Histamine	137-146	endothelin 1	Mus musculus	166-178
7533727-7	1994	On the other hand, treatment with O-O"-bis(2-aminophenyl)ethyleneglycol-N,N,N",N"-tetraacetic acid, tetraacetoxymethyl ester (BAPTA-AM), an intracellular calcium chelating agent, completely inhibited the release induced by both endothelin-1 and compound 48/80.	o-o"-bis(2-aminophenyl)ethyleneglycol-n,n,n",n"-tetraacetic acid	34-98	endothelin 1	Mus musculus	228-240
7533727-7	1994	On the other hand, treatment with O-O"-bis(2-aminophenyl)ethyleneglycol-N,N,N",N"-tetraacetic acid, tetraacetoxymethyl ester (BAPTA-AM), an intracellular calcium chelating agent, completely inhibited the release induced by both endothelin-1 and compound 48/80.	tetraacetoxymethyl ester	100-124	endothelin 1	Mus musculus	228-240
7533727-7	1994	On the other hand, treatment with O-O"-bis(2-aminophenyl)ethyleneglycol-N,N,N",N"-tetraacetic acid, tetraacetoxymethyl ester (BAPTA-AM), an intracellular calcium chelating agent, completely inhibited the release induced by both endothelin-1 and compound 48/80.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	126-134	endothelin 1	Mus musculus	228-240
7533727-8	1994	These results indicate that endothelin-1 is one of the most potent histamine releasers in mouse peritoneal mast cells discovered so far.	Histamine	67-76	endothelin 1	Mus musculus	28-40
7952880-13	1994	Endothelin-1-induced contractions in control preparations were only marginally inhibited by the ETA receptor-selective antagonist BQ-123 (in the presence of 3 micro M BQ-123; EC50 for contraction, 5.9 nM [4.1-8.5]; maximum contraction, 82 +/- 4%Cmax; n = 4).	cyclo(Trp-Asp-Pro-Val-Leu)	167-173	endothelin 1	Mus musculus	0-12
7952880-13	1994	Endothelin-1-induced contractions in control preparations were only marginally inhibited by the ETA receptor-selective antagonist BQ-123 (in the presence of 3 micro M BQ-123; EC50 for contraction, 5.9 nM [4.1-8.5]; maximum contraction, 82 +/- 4%Cmax; n = 4).	cmax	245-249	endothelin 1	Mus musculus	0-12
7522171-0	1994	Endothelin-1 induces release of histamine and leukotriene C4 from mouse bone marrow-derived mast cells.	Histamine	32-41	endothelin 1	Mus musculus	0-12
7837829-0	1994	L-NAME augments the antinociceptive effects of intracerebroventricularly applied ET-1 and ET-3.	NG-Nitroarginine Methyl Ester	0-6	endothelin 1	Mus musculus	81-85
7522171-0	1994	Endothelin-1 induces release of histamine and leukotriene C4 from mouse bone marrow-derived mast cells.	Leukotriene C4	46-60	endothelin 1	Mus musculus	0-12
7522171-3	1994	Endothelin-1 at 1-100 nM concentration dependently induced release of histamine and immunoreactive leukotriene C4 from BMMC, while endothelin-3 at up to 100 nM did not stimulate the release of either mediator.	Histamine	70-79	endothelin 1	Mus musculus	0-12
7522171-3	1994	Endothelin-1 at 1-100 nM concentration dependently induced release of histamine and immunoreactive leukotriene C4 from BMMC, while endothelin-3 at up to 100 nM did not stimulate the release of either mediator.	Leukotriene C4	99-113	endothelin 1	Mus musculus	0-12
7522171-4	1994	Time course experiments revealed that the release of histamine and immunoreactive leukotriene C4 induced by endothelin-1 occurred rapidly, reaching near maximal levels within 20 s and 2 min, respectively, after the stimulation, while histamine release induced by antigen, at the concentration which induced an extent of release similar to that induced by 100 nM endothelin-1, required comparatively prolonged incubation (approximately 10 min for submaximal levels).	Histamine	53-62	endothelin 1	Mus musculus	108-120
7522171-4	1994	Time course experiments revealed that the release of histamine and immunoreactive leukotriene C4 induced by endothelin-1 occurred rapidly, reaching near maximal levels within 20 s and 2 min, respectively, after the stimulation, while histamine release induced by antigen, at the concentration which induced an extent of release similar to that induced by 100 nM endothelin-1, required comparatively prolonged incubation (approximately 10 min for submaximal levels).	Histamine	53-62	endothelin 1	Mus musculus	362-374
7522171-4	1994	Time course experiments revealed that the release of histamine and immunoreactive leukotriene C4 induced by endothelin-1 occurred rapidly, reaching near maximal levels within 20 s and 2 min, respectively, after the stimulation, while histamine release induced by antigen, at the concentration which induced an extent of release similar to that induced by 100 nM endothelin-1, required comparatively prolonged incubation (approximately 10 min for submaximal levels).	Leukotriene C4	82-96	endothelin 1	Mus musculus	108-120
7522171-4	1994	Time course experiments revealed that the release of histamine and immunoreactive leukotriene C4 induced by endothelin-1 occurred rapidly, reaching near maximal levels within 20 s and 2 min, respectively, after the stimulation, while histamine release induced by antigen, at the concentration which induced an extent of release similar to that induced by 100 nM endothelin-1, required comparatively prolonged incubation (approximately 10 min for submaximal levels).	Leukotriene C4	82-96	endothelin 1	Mus musculus	362-374
7522171-4	1994	Time course experiments revealed that the release of histamine and immunoreactive leukotriene C4 induced by endothelin-1 occurred rapidly, reaching near maximal levels within 20 s and 2 min, respectively, after the stimulation, while histamine release induced by antigen, at the concentration which induced an extent of release similar to that induced by 100 nM endothelin-1, required comparatively prolonged incubation (approximately 10 min for submaximal levels).	Histamine	234-243	endothelin 1	Mus musculus	108-120
7522171-5	1994	Cyclo(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123), a selective antagonist of endothelin ETA receptors, not only dissociated [125I]endothelin-1 specifically bound to BMMC but also inhibited the release of both mediators from endothelin-1-induced cells.	emodepside	0-5	endothelin 1	Mus musculus	122-134
7522171-5	1994	Cyclo(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123), a selective antagonist of endothelin ETA receptors, not only dissociated [125I]endothelin-1 specifically bound to BMMC but also inhibited the release of both mediators from endothelin-1-induced cells.	emodepside	0-5	endothelin 1	Mus musculus	216-228
7522171-5	1994	Cyclo(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123), a selective antagonist of endothelin ETA receptors, not only dissociated [125I]endothelin-1 specifically bound to BMMC but also inhibited the release of both mediators from endothelin-1-induced cells.	d-asp-pro-d-val-leu-d-trp	6-31	endothelin 1	Mus musculus	122-134
7522171-5	1994	Cyclo(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123), a selective antagonist of endothelin ETA receptors, not only dissociated [125I]endothelin-1 specifically bound to BMMC but also inhibited the release of both mediators from endothelin-1-induced cells.	cyclo(Trp-Asp-Pro-Val-Leu)	34-40	endothelin 1	Mus musculus	122-134
7522171-5	1994	Cyclo(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123), a selective antagonist of endothelin ETA receptors, not only dissociated [125I]endothelin-1 specifically bound to BMMC but also inhibited the release of both mediators from endothelin-1-induced cells.	cyclo(Trp-Asp-Pro-Val-Leu)	34-40	endothelin 1	Mus musculus	216-228
8205118-4	1994	Three compounds, (2,3-dimercapto-1-propanol (DMP), toluene-3,4-dithiol (TDT) and 8-mercaptoquinoline (8-MQ)), which inhibited ECE in in vitro studies, exhibited inhibitory activity towards big ET-1-induced sudden death in mice, while EDTA did not.	dithiol	51-70	endothelin 1	Mus musculus	193-197
8179600-3	1994	In this study, however, BQ123 inhibited ET-1-induced transients of cytosolic Ca2+ concentrations ([Ca2+]i) in an apparently noncompetitive manner in mouse L cell stably expressing cloned human ETA receptor.	cyclo(Trp-Asp-Pro-Val-Leu)	24-29	endothelin 1	Mus musculus	40-44
8205118-4	1994	Three compounds, (2,3-dimercapto-1-propanol (DMP), toluene-3,4-dithiol (TDT) and 8-mercaptoquinoline (8-MQ)), which inhibited ECE in in vitro studies, exhibited inhibitory activity towards big ET-1-induced sudden death in mice, while EDTA did not.	8-mercaptoquinoline	81-100	endothelin 1	Mus musculus	193-197
8205118-4	1994	Three compounds, (2,3-dimercapto-1-propanol (DMP), toluene-3,4-dithiol (TDT) and 8-mercaptoquinoline (8-MQ)), which inhibited ECE in in vitro studies, exhibited inhibitory activity towards big ET-1-induced sudden death in mice, while EDTA did not.	8-mercaptoquinoline	102-106	endothelin 1	Mus musculus	193-197
8205118-6	1994	Big ET-1-induced hemoconcentration was inhibited by pretreatment with 8-MQ or EDTA but not with DMP or TDT.	8-mercaptoquinoline	70-74	endothelin 1	Mus musculus	4-8
8205118-6	1994	Big ET-1-induced hemoconcentration was inhibited by pretreatment with 8-MQ or EDTA but not with DMP or TDT.	Edetic Acid	78-82	endothelin 1	Mus musculus	4-8
8205118-7	1994	The elevation of immunoreactive ET-1 (IR-ET-1) in plasma after administration of big ET-1 was inhibited by pretreatment with the three compounds but not by EDTA.	Edetic Acid	156-160	endothelin 1	Mus musculus	32-36
8205118-9	1994	Taking into consideration the in vitro results, more selective chelating activity of the compounds towards Zn2+ rather than Ca2+ and Mg2+ may contribute to the inhibition of big ET-1-induced responses in vivo.	Zinc	107-111	endothelin 1	Mus musculus	178-182
8205118-9	1994	Taking into consideration the in vitro results, more selective chelating activity of the compounds towards Zn2+ rather than Ca2+ and Mg2+ may contribute to the inhibition of big ET-1-induced responses in vivo.	magnesium ion	133-137	endothelin 1	Mus musculus	178-182
8425480-4	1993	Like epidermal growth factor, ET-1 caused about a 6-fold increase in progesterone production.	Progesterone	69-81	endothelin 1	Mus musculus	30-34
8255123-5	1993	ET-1 inhibited acetic acid-induced writhings with ED50 = 1.9 (1.1-2.7) pmol/mouse.	Acetic Acid	15-26	endothelin 1	Mus musculus	0-4
8510826-2	1993	The antinociceptive effects of ET-1 were attenuated significantly by pretreatment with naloxone and the delta receptor-selective antagonist naltrindole.	Naloxone	87-95	endothelin 1	Mus musculus	31-35
8510826-2	1993	The antinociceptive effects of ET-1 were attenuated significantly by pretreatment with naloxone and the delta receptor-selective antagonist naltrindole.	naltrindole	140-151	endothelin 1	Mus musculus	31-35
8510826-3	1993	The antinociceptive effects of ET-1 were also significantly attenuated by pretreatment with verapamil, an L-type Ca(2+)-channel blocker.	Verapamil	92-101	endothelin 1	Mus musculus	31-35
8027928-1	1994	Pretreatment with diltiazem at a dose of 2 mg kg-1 intravenously protected against sudden death induced by intravenous administration of endothelin-1 (ET-1, 5 nmol kg-1), with an apparent decrease in the plasma immunoreactive-ET-1 (IR-ET-1) in mice.	Diltiazem	18-27	endothelin 1	Mus musculus	137-149
8027928-1	1994	Pretreatment with diltiazem at a dose of 2 mg kg-1 intravenously protected against sudden death induced by intravenous administration of endothelin-1 (ET-1, 5 nmol kg-1), with an apparent decrease in the plasma immunoreactive-ET-1 (IR-ET-1) in mice.	Diltiazem	18-27	endothelin 1	Mus musculus	151-155
8027928-1	1994	Pretreatment with diltiazem at a dose of 2 mg kg-1 intravenously protected against sudden death induced by intravenous administration of endothelin-1 (ET-1, 5 nmol kg-1), with an apparent decrease in the plasma immunoreactive-ET-1 (IR-ET-1) in mice.	Diltiazem	18-27	endothelin 1	Mus musculus	226-230
8027928-1	1994	Pretreatment with diltiazem at a dose of 2 mg kg-1 intravenously protected against sudden death induced by intravenous administration of endothelin-1 (ET-1, 5 nmol kg-1), with an apparent decrease in the plasma immunoreactive-ET-1 (IR-ET-1) in mice.	Diltiazem	18-27	endothelin 1	Mus musculus	226-230
8027928-4	1994	Furthermore, in anaesthetized rats, diltiazem inhibited ET-1-induced decreases in renal blood flow and increased renal accumulation of IR-ET-1.	Diltiazem	36-45	endothelin 1	Mus musculus	138-142
8368264-1	1993	We tested the effects of endothelin-1 (ET-1) on intracellular calcium concentration ([Ca2+]i) of cultured M-1 mouse cortical collecting duct cells.	Calcium	62-69	endothelin 1	Mus musculus	25-37
8368264-1	1993	We tested the effects of endothelin-1 (ET-1) on intracellular calcium concentration ([Ca2+]i) of cultured M-1 mouse cortical collecting duct cells.	Calcium	62-69	endothelin 1	Mus musculus	39-43
8368264-3	1993	At a concentration of extracellular calcium ([Ca2+]o) of 1 mM, ET-1 (10(-12) to 10(-7) M) increased [Ca2+]i.	Calcium	36-43	endothelin 1	Mus musculus	63-67
8368264-6	1993	In the absence of extracellular Ca2+ (1 mM EGTA) ET-1 also elicited a Ca2+ peak, indicating participation of Ca2+ release from intracellular stores in the initial Ca2+ peak.	Egtazic Acid	43-47	endothelin 1	Mus musculus	49-53
8368264-9	1993	We conclude that ET-1 mediates an increase in [Ca2+]i by Ca2+ release from intracellular stores and activation of a nickel- and nifedipine-sensitive Ca2+ entry mechanism.	Nickel	116-122	endothelin 1	Mus musculus	17-21
8368264-9	1993	We conclude that ET-1 mediates an increase in [Ca2+]i by Ca2+ release from intracellular stores and activation of a nickel- and nifedipine-sensitive Ca2+ entry mechanism.	Nifedipine	128-138	endothelin 1	Mus musculus	17-21
8425480-7	1993	The results of this study demonstrate that MA-10 cells possess high affinity binding sites for ET-1 and that ET-1 stimulates progesterone production and protooncogene expression, but not mitosis in this cell line.	Progesterone	125-137	endothelin 1	Mus musculus	109-113
1625506-4	1992	The opioid receptor antagonist naloxone did not antagonize, and the cyclooxygenase inhibitors indomethacin and diclofenac slightly inhibited the ET-1 effect.	Indomethacin	94-106	endothelin 1	Mus musculus	145-149
1639010-0	1992	Endothelin-1 actions on resorption, collagen and noncollagen protein synthesis, and phosphatidylinositol turnover in bone organ cultures.	Phosphatidylinositols	84-104	endothelin 1	Mus musculus	0-12
1639010-1	1992	The effects of endothelin-1 (ET) on several tissues are mediated by prostaglandins.	Prostaglandins	68-82	endothelin 1	Mus musculus	15-27
1494299-0	1992	Effects of intracerebroventricular endothelin-1 on CNS and cerebral hypoxia/ischemia and their modification by cinnarizine.	Cinnarizine	111-122	endothelin 1	Mus musculus	35-47
1494299-12	1992	Cinnarizine attenuated the appearance of barrel-rolling, did not antagonize disturbances in motor activity and reversed the antinociceptive effect of ET-1.	Cinnarizine	0-11	endothelin 1	Mus musculus	150-154
1494299-13	1992	In hypobaric hypoxia and decapitation cinnarizine antagonized the effects of 5 pmol/mouse ET-1 and potentiated that of 1.25 pmol/mouse.	Cinnarizine	38-49	endothelin 1	Mus musculus	90-94
1494299-14	1992	The pharmacological modification of the ET-1 effects by cinnarizine strongly suggests that the CNS actions of ET-1 might be due to multiple mechanisms triggered by an increased influx of extracellular Ca2+ into the brain cells.	Cinnarizine	56-67	endothelin 1	Mus musculus	40-44
1494299-14	1992	The pharmacological modification of the ET-1 effects by cinnarizine strongly suggests that the CNS actions of ET-1 might be due to multiple mechanisms triggered by an increased influx of extracellular Ca2+ into the brain cells.	Cinnarizine	56-67	endothelin 1	Mus musculus	110-114
1504742-6	1992	ET-1 (0.5 pmol/paw) also inhibited paw oedema (3-4 h) caused by zymosan (500 micrograms/paw).	Zymosan	64-71	endothelin 1	Mus musculus	0-4
1323477-1	1992	In permeabilized C6 glioma cells and NIH 3T3 cells, the peptide endothelin 1 (ET-1) in combination with GTP gamma S stimulates the formation of inositol phosphates.	Inositol Phosphates	144-163	endothelin 1	Mus musculus	64-76
1625506-4	1992	The opioid receptor antagonist naloxone did not antagonize, and the cyclooxygenase inhibitors indomethacin and diclofenac slightly inhibited the ET-1 effect.	Diclofenac	111-121	endothelin 1	Mus musculus	145-149
1625506-5	1992	The calcium overload blocker cinnarizine antagonized the antinociceptive effect of ET-1, suggesting that the ET-1 effect might be Ca(2+)-mediated.	Cinnarizine	29-40	endothelin 1	Mus musculus	83-87
1625506-5	1992	The calcium overload blocker cinnarizine antagonized the antinociceptive effect of ET-1, suggesting that the ET-1 effect might be Ca(2+)-mediated.	Cinnarizine	29-40	endothelin 1	Mus musculus	109-113
1579051-0	1992	Big endothelin-1-induced sudden death is inhibited by phosphoramidon in mice.	phosphoramidon	54-68	endothelin 1	Mus musculus	4-16
12106434-3	1992	In the present study, it will be shown that ET-1 and ET-3 markedly stimulate the release of arachidonic acid (AA) from cultured astrocytes from the mouse striatum (EC50=3 and 7 nM for ET-1 and ET-3, respectively), mesencephalon and cerebral cortex.	Arachidonic Acid	92-108	endothelin 1	Mus musculus	44-57
12106434-3	1992	In the present study, it will be shown that ET-1 and ET-3 markedly stimulate the release of arachidonic acid (AA) from cultured astrocytes from the mouse striatum (EC50=3 and 7 nM for ET-1 and ET-3, respectively), mesencephalon and cerebral cortex.	Arachidonic Acid	92-108	endothelin 1	Mus musculus	184-197
12106311-3	1992	In astrocytes, endothelins induce changes in the concentration of several second messengers (calcium, diacylglycerol, arachidonic acid, cAMP) known to be involved in the regulation of gap junction channels.	Calcium	93-100	endothelin 1	Mus musculus	15-26
12106311-3	1992	In astrocytes, endothelins induce changes in the concentration of several second messengers (calcium, diacylglycerol, arachidonic acid, cAMP) known to be involved in the regulation of gap junction channels.	Diglycerides	102-116	endothelin 1	Mus musculus	15-26
12106311-3	1992	In astrocytes, endothelins induce changes in the concentration of several second messengers (calcium, diacylglycerol, arachidonic acid, cAMP) known to be involved in the regulation of gap junction channels.	Arachidonic Acid	118-134	endothelin 1	Mus musculus	15-26
12106311-3	1992	In astrocytes, endothelins induce changes in the concentration of several second messengers (calcium, diacylglycerol, arachidonic acid, cAMP) known to be involved in the regulation of gap junction channels.	Cyclic AMP	136-140	endothelin 1	Mus musculus	15-26
12106311-7	1992	In the absence of extracellular calcium, the effects of endothelins were largely prevented, suggesting that second messengers linked to the activation of phospholipases C and/or A2, which both are dependent on external calcium, could be involved in the uncoupling mechanism.	Calcium	219-226	endothelin 1	Mus musculus	56-67
1579051-4	1992	A metalloproteinase inhibitor, phosphoramidon, although failing to inhibit sudden death induced by ET-1, suppressed bET-1-induced lethality and elevation of plasma IR-ET-1 probably due to an inhibition of the enzymatic conversion of bET-1 to ET-1.	phosphoramidon	31-45	endothelin 1	Mus musculus	117-121
1579051-4	1992	A metalloproteinase inhibitor, phosphoramidon, although failing to inhibit sudden death induced by ET-1, suppressed bET-1-induced lethality and elevation of plasma IR-ET-1 probably due to an inhibition of the enzymatic conversion of bET-1 to ET-1.	phosphoramidon	31-45	endothelin 1	Mus musculus	117-121
1667686-1	1991	Biotinylated derivatives of endothelin (ET)-1 were prepared by chemical modification of ET-1 with sulfosuccinimidyl 6-(biotinamido) hexanoate.	sulfosuccinimidyl 6-(biotinamido)hexanoate	98-141	endothelin 1	Mus musculus	28-45
1718168-0	1991	Endothelin 1 increases cell calcium in mouse collecting tubule cells.	Calcium	28-35	endothelin 1	Mus musculus	0-12
1865355-5	1991	These results suggest that peak Ca++i responses to ET-1 involve mobilization of Ca++ from inositol phosphate-sensitive intracellular stores and influx of extracellular Ca++ through nonclassical Ca++ channels, whereas plateau responses are mediated by Ca++ influx through dihydropyridine-sensitive, voltage-gated channels.	Inositol Phosphates	90-108	endothelin 1	Mus musculus	51-55
1865355-5	1991	These results suggest that peak Ca++i responses to ET-1 involve mobilization of Ca++ from inositol phosphate-sensitive intracellular stores and influx of extracellular Ca++ through nonclassical Ca++ channels, whereas plateau responses are mediated by Ca++ influx through dihydropyridine-sensitive, voltage-gated channels.	1,4-dihydropyridine	271-286	endothelin 1	Mus musculus	51-55
2059205-0	1991	SK&amp;F 96365, a receptor-mediated calcium entry inhibitor, inhibits calcium responses to endothelin-1 in NG108-15 cells.	amicloral	0-6	endothelin 1	Mus musculus	91-103
2059205-0	1991	SK&amp;F 96365, a receptor-mediated calcium entry inhibitor, inhibits calcium responses to endothelin-1 in NG108-15 cells.	Calcium	36-43	endothelin 1	Mus musculus	91-103
2059205-1	1991	Endothelin-1 increases intracellular Ca2+ in NG108-15 cells by mobilizing Ca2+ from internal stores and by activating Ca2+ entry through dihydropyridine-sensitive, voltage-gated channels and another, unidentified route.	1,4-dihydropyridine	137-152	endothelin 1	Mus musculus	0-12
2059205-2	1991	Since SK&amp;F 96365 has recently been reported to inhibit receptor-mediated Ca2+ entry in other systems, we examined its effect on intracellular Ca2+ responses to endothelin-1, measured with the fluorescent Ca2+ indicator fura-2, in NG108-15 cells.	amicloral	6-12	endothelin 1	Mus musculus	164-176
2059205-3	1991	SK&amp;F 96365 (30 microM) reduced both dihydropyridine-insensitive (peak) and dihydropyridine-sensitive (plateau) components of intracellular Ca2+ responses to 5 nM endothelin-1.	1,4-dihydropyridine	79-94	endothelin 1	Mus musculus	166-178
2059205-4	1991	In the presence of 100 nM nimodipine, which blocks dihydropyridine-sensitive channels, SK&amp;F 96365 caused concentration-dependent inhibition of Ca2+ responses to 5 nM endothelin-1, with half-maximal inhibition at 16 microM.	Nimodipine	26-36	endothelin 1	Mus musculus	170-182