PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
16603734-6	2006	These data establish genetically that either HGPRT or XPRT is absolutely essential for purine acquisition, parasite viability, and parasite infectivity of mouse macrophages, that all exogenous purines are funneled to hypoxanthine and/or xanthine by L. donovani, and that the purine sources within the macrophage to which the parasites have access are HGPRT or XPRT substrates.	purine	87-93	xanthine phosphoribosyltransferase	Leishmania donovani	54-58
16603734-0	2006	A conditional mutant deficient in hypoxanthine-guanine phosphoribosyltransferase and xanthine phosphoribosyltransferase validates the purine salvage pathway of Leishmania donovani.	purine	134-140	xanthine phosphoribosyltransferase	Leishmania donovani	85-119
16603734-6	2006	These data establish genetically that either HGPRT or XPRT is absolutely essential for purine acquisition, parasite viability, and parasite infectivity of mouse macrophages, that all exogenous purines are funneled to hypoxanthine and/or xanthine by L. donovani, and that the purine sources within the macrophage to which the parasites have access are HGPRT or XPRT substrates.	Purines	193-200	xanthine phosphoribosyltransferase	Leishmania donovani	360-364
16603734-2	2006	Previous efforts to generate an L. donovani strain deficient in both hypoxanthine-guanine phosphoribosyl-transferase (HGPRT) and xanthine phosphoribosyltransferase (XPRT) using gene replacement approaches were not successful, lending indirect support to the hypothesis that either HGPRT or XPRT is crucial for purine salvage by the parasite.	purine	310-316	xanthine phosphoribosyltransferase	Leishmania donovani	165-169
16603734-6	2006	These data establish genetically that either HGPRT or XPRT is absolutely essential for purine acquisition, parasite viability, and parasite infectivity of mouse macrophages, that all exogenous purines are funneled to hypoxanthine and/or xanthine by L. donovani, and that the purine sources within the macrophage to which the parasites have access are HGPRT or XPRT substrates.	purine	193-199	xanthine phosphoribosyltransferase	Leishmania donovani	360-364
16603734-3	2006	We now report the genetic confirmation of this hypothesis through the construction of a conditional delta hgprt/delta xprt mutant strain that exhibits an absolute requirement for 2"-deoxycoformycin, an inhibitor of the leishmanial adenine aminohydrolase enzyme, and either adenine or adenosine as a source of purine.	Pentostatin	179-197	xanthine phosphoribosyltransferase	Leishmania donovani	118-122
10567419-3	1999	To investigate the enzyme at the molecular and biochemical level, a cDNA encoding the L. donovani XPRT was isolated by functional complementation of a purine auxotroph of Escherichia coli that also harbors deficiencies in the prokaryotic phosphoribosyltransferase (PRT) activities.	purine	151-157	xanthine phosphoribosyltransferase	Leishmania donovani	98-102
16603734-3	2006	We now report the genetic confirmation of this hypothesis through the construction of a conditional delta hgprt/delta xprt mutant strain that exhibits an absolute requirement for 2"-deoxycoformycin, an inhibitor of the leishmanial adenine aminohydrolase enzyme, and either adenine or adenosine as a source of purine.	Adenine	231-238	xanthine phosphoribosyltransferase	Leishmania donovani	118-122
10567419-11	1999	Kinetic analysis revealed that the XPRT preferentially phosphoribosylated xanthine but could also recognize hypoxanthine and guanine.	Xanthine	74-82	xanthine phosphoribosyltransferase	Leishmania donovani	35-39
10567419-11	1999	Kinetic analysis revealed that the XPRT preferentially phosphoribosylated xanthine but could also recognize hypoxanthine and guanine.	Hypoxanthine	108-120	xanthine phosphoribosyltransferase	Leishmania donovani	35-39
10567419-11	1999	Kinetic analysis revealed that the XPRT preferentially phosphoribosylated xanthine but could also recognize hypoxanthine and guanine.	Guanine	125-132	xanthine phosphoribosyltransferase	Leishmania donovani	35-39
29233758-1	2018	Among all PRT enzymes of purine salvage pathway in Leishmania, XPRT (Xanthine phosphoribosyl transferase) is unique in its substrate specificity and their non-existence in human.	purine	25-31	xanthine phosphoribosyltransferase	Leishmania donovani	63-67
29233758-1	2018	Among all PRT enzymes of purine salvage pathway in Leishmania, XPRT (Xanthine phosphoribosyl transferase) is unique in its substrate specificity and their non-existence in human.	purine	25-31	xanthine phosphoribosyltransferase	Leishmania donovani	69-104
29233758-3	2018	Analysis of the 3D model of L. donovani XPRT (Ld-XPRT) revealed that Ile 209, Glu 215 and Tyr 208 may be responsible for the altered substrate specificity of Ld-XPRT.	Isoleucine	69-72	xanthine phosphoribosyltransferase	Leishmania donovani	40-44
29233758-3	2018	Analysis of the 3D model of L. donovani XPRT (Ld-XPRT) revealed that Ile 209, Glu 215 and Tyr 208 may be responsible for the altered substrate specificity of Ld-XPRT.	Isoleucine	69-72	xanthine phosphoribosyltransferase	Leishmania donovani	49-53
29233758-3	2018	Analysis of the 3D model of L. donovani XPRT (Ld-XPRT) revealed that Ile 209, Glu 215 and Tyr 208 may be responsible for the altered substrate specificity of Ld-XPRT.	Isoleucine	69-72	xanthine phosphoribosyltransferase	Leishmania donovani	49-53
29233758-3	2018	Analysis of the 3D model of L. donovani XPRT (Ld-XPRT) revealed that Ile 209, Glu 215 and Tyr 208 may be responsible for the altered substrate specificity of Ld-XPRT.	Glutamic Acid	78-81	xanthine phosphoribosyltransferase	Leishmania donovani	40-44
29233758-3	2018	Analysis of the 3D model of L. donovani XPRT (Ld-XPRT) revealed that Ile 209, Glu 215 and Tyr 208 may be responsible for the altered substrate specificity of Ld-XPRT.	Glutamic Acid	78-81	xanthine phosphoribosyltransferase	Leishmania donovani	49-53
29233758-3	2018	Analysis of the 3D model of L. donovani XPRT (Ld-XPRT) revealed that Ile 209, Glu 215 and Tyr 208 may be responsible for the altered substrate specificity of Ld-XPRT.	Glutamic Acid	78-81	xanthine phosphoribosyltransferase	Leishmania donovani	49-53
29233758-3	2018	Analysis of the 3D model of L. donovani XPRT (Ld-XPRT) revealed that Ile 209, Glu 215 and Tyr 208 may be responsible for the altered substrate specificity of Ld-XPRT.	Tyrosine	90-93	xanthine phosphoribosyltransferase	Leishmania donovani	40-44
29233758-3	2018	Analysis of the 3D model of L. donovani XPRT (Ld-XPRT) revealed that Ile 209, Glu 215 and Tyr 208 may be responsible for the altered substrate specificity of Ld-XPRT.	Tyrosine	90-93	xanthine phosphoribosyltransferase	Leishmania donovani	49-53
29233758-3	2018	Analysis of the 3D model of L. donovani XPRT (Ld-XPRT) revealed that Ile 209, Glu 215 and Tyr 208 may be responsible for the altered substrate specificity of Ld-XPRT.	Tyrosine	90-93	xanthine phosphoribosyltransferase	Leishmania donovani	49-53
29233758-6	2018	In kinetic analysis, Ld-XPRT could phosphoribosylate xanthine, hypoxanthine and guanine with Km values of 7.27, 8.13, 8.48muM and kcat values of 2.24, 1.82, 1.19min-1 respectively.	phosphoribosylate xanthine	35-61	xanthine phosphoribosyltransferase	Leishmania donovani	24-28
29233758-6	2018	In kinetic analysis, Ld-XPRT could phosphoribosylate xanthine, hypoxanthine and guanine with Km values of 7.27, 8.13, 8.48muM and kcat values of 2.24, 1.82, 1.19min-1 respectively.	Hypoxanthine	63-75	xanthine phosphoribosyltransferase	Leishmania donovani	24-28
29233758-6	2018	In kinetic analysis, Ld-XPRT could phosphoribosylate xanthine, hypoxanthine and guanine with Km values of 7.27, 8.13, 8.48muM and kcat values of 2.24, 1.82, 1.19min-1 respectively.	Guanine	80-87	xanthine phosphoribosyltransferase	Leishmania donovani	24-28
29233758-9	2018	Four compounds are bi-substrate analogues and show competitive inhibition with both the substrates (Xanthine and PRPP) of Ld-XPRT.	Xanthine	100-108	xanthine phosphoribosyltransferase	Leishmania donovani	125-129
29233758-9	2018	Four compounds are bi-substrate analogues and show competitive inhibition with both the substrates (Xanthine and PRPP) of Ld-XPRT.	Phosphoribosyl Pyrophosphate	113-117	xanthine phosphoribosyltransferase	Leishmania donovani	125-129
29233758-11	2018	Two Ld-XPRT inhibitors (dGDP and cGMP), which also have ability to inhibit Leishmanial HGPRT, are predicted as potential drug candidates as it can inhibit both the important enzymes of the purine salvage pathway.	Cyclic GMP	33-37	xanthine phosphoribosyltransferase	Leishmania donovani	7-11
29233758-11	2018	Two Ld-XPRT inhibitors (dGDP and cGMP), which also have ability to inhibit Leishmanial HGPRT, are predicted as potential drug candidates as it can inhibit both the important enzymes of the purine salvage pathway.	purine	189-195	xanthine phosphoribosyltransferase	Leishmania donovani	7-11
20363738-5	2010	281, 16084-16089) that establishes that L. donovani salvages purines primarily through hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and xanthine phosphoribosyltransferase (XPRT).	Purines	61-68	xanthine phosphoribosyltransferase	Leishmania donovani	146-180