PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
24124444-0	2013	A Ham1p-dependent mechanism and modulation of the pyrimidine biosynthetic pathway can both confer resistance to 5-fluorouracil in yeast.	Fluorouracil	112-126	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	2-7
29738539-2	2018	In the yeast Saccharomyces cerevisiae, overexpression of the HAM1 gene encoding inosine triphosphate pyrophosphatase confers resistance to both the purine analogue 6-N-hydroxylaminopurine (HAP) and the pyrimidine analogue 5-fluorouracil (5-FU) (Carlsson et al., 2013, PLoS One 8, e52094).	purine	148-154	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	61-65
29738539-2	2018	In the yeast Saccharomyces cerevisiae, overexpression of the HAM1 gene encoding inosine triphosphate pyrophosphatase confers resistance to both the purine analogue 6-N-hydroxylaminopurine (HAP) and the pyrimidine analogue 5-fluorouracil (5-FU) (Carlsson et al., 2013, PLoS One 8, e52094).	6-N-hydroxylaminopurine	164-187	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	61-65
29738539-2	2018	In the yeast Saccharomyces cerevisiae, overexpression of the HAM1 gene encoding inosine triphosphate pyrophosphatase confers resistance to both the purine analogue 6-N-hydroxylaminopurine (HAP) and the pyrimidine analogue 5-fluorouracil (5-FU) (Carlsson et al., 2013, PLoS One 8, e52094).	pyrimidine	202-212	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	61-65
29738539-2	2018	In the yeast Saccharomyces cerevisiae, overexpression of the HAM1 gene encoding inosine triphosphate pyrophosphatase confers resistance to both the purine analogue 6-N-hydroxylaminopurine (HAP) and the pyrimidine analogue 5-fluorouracil (5-FU) (Carlsson et al., 2013, PLoS One 8, e52094).	Fluorouracil	222-236	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	61-65
29738539-2	2018	In the yeast Saccharomyces cerevisiae, overexpression of the HAM1 gene encoding inosine triphosphate pyrophosphatase confers resistance to both the purine analogue 6-N-hydroxylaminopurine (HAP) and the pyrimidine analogue 5-fluorouracil (5-FU) (Carlsson et al., 2013, PLoS One 8, e52094).	Fluorouracil	238-242	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	61-65
29738539-6	2018	We found that HMS1, LOG1 (YJL055W), HAM1, and ATR1 confer resistance to both 5-FU and HAP, whereas ADE4, DUT1 and APT2 are specific for HAP resistance, and CPA1 and CPA2 specific for 5-FU resistance.	Fluorouracil	77-81	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	36-40
24124444-8	2013	In contrast, HAM1 and YJL055W confer 5-FU resistance in a ura2 mutant, and selectively inhibit incorporation into RNA of 5-FU but not uracil.	Fluorouracil	37-41	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	13-17
24124444-8	2013	In contrast, HAM1 and YJL055W confer 5-FU resistance in a ura2 mutant, and selectively inhibit incorporation into RNA of 5-FU but not uracil.	Fluorouracil	121-125	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	13-17
24124444-8	2013	In contrast, HAM1 and YJL055W confer 5-FU resistance in a ura2 mutant, and selectively inhibit incorporation into RNA of 5-FU but not uracil.	Uracil	134-140	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	13-17
24124444-10	2013	This suggests that HAM1 and YJL055W function together in mediating resistance to 5-FU.	Fluorouracil	81-85	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	19-23
24124444-11	2013	Ham1p encodes an inosine triphosphate pyrophosphatase that has been implicated in resistance to purine analogues.	purine	96-102	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	0-5
24124444-12	2013	Our results suggest that Ham1p could have a broader specificity that includes 5-FUTP and other pyrimidine analogoue triphosphates.	5-futp	78-84	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	25-30
24124444-12	2013	Our results suggest that Ham1p could have a broader specificity that includes 5-FUTP and other pyrimidine analogoue triphosphates.	pyrimidine	95-105	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	25-30
24124444-12	2013	Our results suggest that Ham1p could have a broader specificity that includes 5-FUTP and other pyrimidine analogoue triphosphates.	triphosphoric acid	116-129	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	25-30
19514135-6	2009	This indicates that genes ADE12, ADE13, AAH1, and HAM1 controlling processes of purine utilization and interconversion in yeast make the greatest contribution to the system of protection against the toxic and mutagenic action of the examined analogs.	purine	80-86	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	50-54
17899088-0	2007	Overexpression of HAM1 gene detoxifies 5-bromodeoxyuridine in the yeast Saccharomyces cerevisiae.	Bromodeoxyuridine	39-58	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	18-22
17899088-4	2007	One of such genes was found to encode Ham1 protein, which was originally identified as a possible triphosphatase for N-6-hydroxylaminopurine triphosphate.	n-6-hydroxylaminopurine triphosphate	117-153	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	38-42
17899088-5	2007	Consistent with this, overexpression of the HAM1 gene reversed growth arrest caused by BrdU, and blocked incorporation of BrdU into genomic DNA.	Bromodeoxyuridine	87-91	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	44-48
17899088-5	2007	Consistent with this, overexpression of the HAM1 gene reversed growth arrest caused by BrdU, and blocked incorporation of BrdU into genomic DNA.	Bromodeoxyuridine	122-126	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	44-48
17899088-7	2007	A crude extract from Ham1-overproducing cells showed a high activity to hydrolyze BrdUTP to BrdUMP and pyrophosphate in addition to abnormal purine nucleotides.	brdump	92-98	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	21-25
17899088-7	2007	A crude extract from Ham1-overproducing cells showed a high activity to hydrolyze BrdUTP to BrdUMP and pyrophosphate in addition to abnormal purine nucleotides.	diphosphoric acid	103-116	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	21-25
17899088-7	2007	A crude extract from Ham1-overproducing cells showed a high activity to hydrolyze BrdUTP to BrdUMP and pyrophosphate in addition to abnormal purine nucleotides.	purine	141-147	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	21-25
17899088-9	2007	These results demonstrate that Ham1 protein detoxifies abnormal pyrimidine as well as purine nucleotides.	pyrimidine	64-74	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	31-35
17899088-9	2007	These results demonstrate that Ham1 protein detoxifies abnormal pyrimidine as well as purine nucleotides.	Purine Nucleotides	86-104	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	31-35
9273315-3	1997	Haploid strains with the double mutation ham1 ade2 or ham1 ade5 were also incapable of growing on a medium with 6-N-hydroxylaminopurine (HAP) as a sole purine source.	6-N-hydroxylaminopurine	137-140	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	54-63
9273315-3	1997	Haploid strains with the double mutation ham1 ade2 or ham1 ade5 were also incapable of growing on a medium with 6-N-hydroxylaminopurine (HAP) as a sole purine source.	purine	129-135	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	41-45
9273315-3	1997	Haploid strains with the double mutation ham1 ade2 or ham1 ade5 were also incapable of growing on a medium with 6-N-hydroxylaminopurine (HAP) as a sole purine source.	purine	129-135	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	54-63
9918490-0	1998	Overexpression of the yeast HAM1 gene prevents 6-N-hydroxylaminopurine mutagenesis in Escherichia coli.	6-N-hydroxylaminopurine	47-70	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	28-32
9273315-3	1997	Haploid strains with the double mutation ham1 ade2 or ham1 ade5 were also incapable of growing on a medium with 6-N-hydroxylaminopurine (HAP) as a sole purine source.	6-N-hydroxylaminopurine	112-135	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	41-45
9273315-3	1997	Haploid strains with the double mutation ham1 ade2 or ham1 ade5 were also incapable of growing on a medium with 6-N-hydroxylaminopurine (HAP) as a sole purine source.	6-N-hydroxylaminopurine	112-135	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	54-63
9273315-3	1997	Haploid strains with the double mutation ham1 ade2 or ham1 ade5 were also incapable of growing on a medium with 6-N-hydroxylaminopurine (HAP) as a sole purine source.	6-N-hydroxylaminopurine	137-140	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	41-45
8789257-0	1996	HAM1, the gene controlling 6-N-hydroxylaminopurine sensitivity and mutagenesis in the yeast Saccharomyces cerevisiae.	6-N-hydroxylaminopurine	27-50	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	0-4
8789257-1	1996	The ham1 mutant of yeast Saccharomyces cerevisiae is sensitive to the mutagenic and lethal effects of the base analog, 6-N-hydroxylaminopurine (HAP).	6-N-hydroxylaminopurine	119-142	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	4-8
8789257-1	1996	The ham1 mutant of yeast Saccharomyces cerevisiae is sensitive to the mutagenic and lethal effects of the base analog, 6-N-hydroxylaminopurine (HAP).	6-N-hydroxylaminopurine	144-147	nucleoside triphosphate pyrophosphohydrolase HAM1	Saccharomyces cerevisiae S288C	4-8