PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
29352744-1	2018	ADP-dependent glucokinase (ADPGK) is an alternative novel glucose phosphorylating enzyme in a modified glycolysis pathway of hyperthermophilic Archaea.	Glucose	58-65	ADP dependent glucokinase	Homo sapiens	27-32
29352744-2	2018	In contrast to classical ATP-dependent hexokinases, ADPGK utilizes ADP as a phosphoryl group donor.	Adenosine Triphosphate	25-28	ADP dependent glucokinase	Homo sapiens	52-57
29352744-3	2018	Here, we present a crystal structure of archaeal ADPGK from Methanocaldococcus jannaschii in complex with an inhibitor, 5-iodotubercidin, d-glucose, inorganic phosphate, and a magnesium ion.	5-iodotubercidin	120-136	ADP dependent glucokinase	Homo sapiens	49-54
29352744-3	2018	Here, we present a crystal structure of archaeal ADPGK from Methanocaldococcus jannaschii in complex with an inhibitor, 5-iodotubercidin, d-glucose, inorganic phosphate, and a magnesium ion.	Glucose	138-147	ADP dependent glucokinase	Homo sapiens	49-54
29352744-3	2018	Here, we present a crystal structure of archaeal ADPGK from Methanocaldococcus jannaschii in complex with an inhibitor, 5-iodotubercidin, d-glucose, inorganic phosphate, and a magnesium ion.	Phosphates	149-168	ADP dependent glucokinase	Homo sapiens	49-54
29352744-3	2018	Here, we present a crystal structure of archaeal ADPGK from Methanocaldococcus jannaschii in complex with an inhibitor, 5-iodotubercidin, d-glucose, inorganic phosphate, and a magnesium ion.	Magnesium	176-185	ADP dependent glucokinase	Homo sapiens	49-54
29352744-6	2018	In addition, we demonstrate that 5-iodotubercidin inhibits human ADPGK-dependent T cell activation-induced reactive oxygen species (ROS) release and downstream gene expression, and as such it may serve as a model compound for further screening for hADPGK-specific inhibitors.	5-iodotubercidin	33-49	ADP dependent glucokinase	Homo sapiens	65-70
29352744-6	2018	In addition, we demonstrate that 5-iodotubercidin inhibits human ADPGK-dependent T cell activation-induced reactive oxygen species (ROS) release and downstream gene expression, and as such it may serve as a model compound for further screening for hADPGK-specific inhibitors.	Reactive Oxygen Species	107-130	ADP dependent glucokinase	Homo sapiens	65-70
29352744-6	2018	In addition, we demonstrate that 5-iodotubercidin inhibits human ADPGK-dependent T cell activation-induced reactive oxygen species (ROS) release and downstream gene expression, and as such it may serve as a model compound for further screening for hADPGK-specific inhibitors.	Reactive Oxygen Species	132-135	ADP dependent glucokinase	Homo sapiens	65-70
26555263-2	2016	ADP-dependent glucokinase (ADPGK) catalyzes glucose-6-phosphate production, utilizing ADP as a phosphoryl donor in contrast to the more well characterized ATP-requiring hexokinases.	Glucose-6-Phosphate	44-63	ADP dependent glucokinase	Homo sapiens	0-25
26555263-2	2016	ADP-dependent glucokinase (ADPGK) catalyzes glucose-6-phosphate production, utilizing ADP as a phosphoryl donor in contrast to the more well characterized ATP-requiring hexokinases.	Glucose-6-Phosphate	44-63	ADP dependent glucokinase	Homo sapiens	27-32
26555263-2	2016	ADP-dependent glucokinase (ADPGK) catalyzes glucose-6-phosphate production, utilizing ADP as a phosphoryl donor in contrast to the more well characterized ATP-requiring hexokinases.	Adenosine Diphosphate	0-3	ADP dependent glucokinase	Homo sapiens	27-32
26555263-2	2016	ADP-dependent glucokinase (ADPGK) catalyzes glucose-6-phosphate production, utilizing ADP as a phosphoryl donor in contrast to the more well characterized ATP-requiring hexokinases.	Adenosine Triphosphate	155-158	ADP dependent glucokinase	Homo sapiens	0-25
26555263-2	2016	ADP-dependent glucokinase (ADPGK) catalyzes glucose-6-phosphate production, utilizing ADP as a phosphoryl donor in contrast to the more well characterized ATP-requiring hexokinases.	Adenosine Triphosphate	155-158	ADP dependent glucokinase	Homo sapiens	27-32
26555263-5	2016	Both the unliganded and the AMP-bound ADPGK structures are in the "open" conformation.	Adenosine Monophosphate	28-31	ADP dependent glucokinase	Homo sapiens	38-43
26555263-6	2016	The structures reveal the presence of a disulfide bond between conserved cysteines that is positioned at the nucleotide-binding loop of eukaryotic ADPGK.	Disulfides	40-49	ADP dependent glucokinase	Homo sapiens	147-152
26555263-6	2016	The structures reveal the presence of a disulfide bond between conserved cysteines that is positioned at the nucleotide-binding loop of eukaryotic ADPGK.	Cysteine	73-82	ADP dependent glucokinase	Homo sapiens	147-152
26555263-7	2016	The AMP-bound ADPGK structure defines the nucleotide-binding site with one of the disulfide bond cysteines coordinating the AMP with its main chain atoms, a nucleotide-binding motif that appears unique to eukaryotic ADPGKs.	Adenosine Monophosphate	4-7	ADP dependent glucokinase	Homo sapiens	14-19
26555263-7	2016	The AMP-bound ADPGK structure defines the nucleotide-binding site with one of the disulfide bond cysteines coordinating the AMP with its main chain atoms, a nucleotide-binding motif that appears unique to eukaryotic ADPGKs.	Disulfides	82-91	ADP dependent glucokinase	Homo sapiens	14-19
26555263-7	2016	The AMP-bound ADPGK structure defines the nucleotide-binding site with one of the disulfide bond cysteines coordinating the AMP with its main chain atoms, a nucleotide-binding motif that appears unique to eukaryotic ADPGKs.	Cysteine	97-106	ADP dependent glucokinase	Homo sapiens	14-19
26555263-7	2016	The AMP-bound ADPGK structure defines the nucleotide-binding site with one of the disulfide bond cysteines coordinating the AMP with its main chain atoms, a nucleotide-binding motif that appears unique to eukaryotic ADPGKs.	Adenosine Monophosphate	124-127	ADP dependent glucokinase	Homo sapiens	14-19
26555263-9	2016	ADPGK is substrate inhibited by high glucose concentration and shows high specificity for glucose, with no activity for other sugars, as determined by NMR spectroscopy, including 2-deoxyglucose, the glucose analogue used for tumor detection by positron emission tomography.	Glucose	37-44	ADP dependent glucokinase	Homo sapiens	0-5
26555263-9	2016	ADPGK is substrate inhibited by high glucose concentration and shows high specificity for glucose, with no activity for other sugars, as determined by NMR spectroscopy, including 2-deoxyglucose, the glucose analogue used for tumor detection by positron emission tomography.	Glucose	90-97	ADP dependent glucokinase	Homo sapiens	0-5
26555263-9	2016	ADPGK is substrate inhibited by high glucose concentration and shows high specificity for glucose, with no activity for other sugars, as determined by NMR spectroscopy, including 2-deoxyglucose, the glucose analogue used for tumor detection by positron emission tomography.	Sugars	126-132	ADP dependent glucokinase	Homo sapiens	0-5
26555263-9	2016	ADPGK is substrate inhibited by high glucose concentration and shows high specificity for glucose, with no activity for other sugars, as determined by NMR spectroscopy, including 2-deoxyglucose, the glucose analogue used for tumor detection by positron emission tomography.	Deoxyglucose	179-193	ADP dependent glucokinase	Homo sapiens	0-5
26555263-9	2016	ADPGK is substrate inhibited by high glucose concentration and shows high specificity for glucose, with no activity for other sugars, as determined by NMR spectroscopy, including 2-deoxyglucose, the glucose analogue used for tumor detection by positron emission tomography.	Glucose	90-97	ADP dependent glucokinase	Homo sapiens	0-5
23168256-0	2012	T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation.	Reactive Oxygen Species	107-130	ADP dependent glucokinase	Homo sapiens	34-59
23168256-4	2012	The ADPGK-driven increase in glycolytic metabolism coincides with TCR-induced glucose uptake, downregulation of mitochondrial respiration, and deviation of glycolysis toward mitochondrial glycerol-3-phosphate dehydrogenase(GPD) shuttle; i.e., a metabolic shift to aerobic glycolysis similar to the Warburg effect.	Glucose	78-85	ADP dependent glucokinase	Homo sapiens	4-9
29784881-0	2018	Structural basis for ADP-dependent glucokinase inhibition by 8-bromo-substituted adenosine nucleotide.	8-bromo-substituted adenosine nucleotide	61-101	ADP dependent glucokinase	Homo sapiens	21-46
29784881-2	2018	In contrast to canonical hexokinases, which use ATP, ADP-dependent glucokinase (ADPGK) catalyzes noncanonical phosphorylation of glucose to glucose 6-phosphate using ADP as a phosphate donor.	Adenosine Triphosphate	48-51	ADP dependent glucokinase	Homo sapiens	53-78
29784881-2	2018	In contrast to canonical hexokinases, which use ATP, ADP-dependent glucokinase (ADPGK) catalyzes noncanonical phosphorylation of glucose to glucose 6-phosphate using ADP as a phosphate donor.	Adenosine Triphosphate	48-51	ADP dependent glucokinase	Homo sapiens	80-85
29784881-2	2018	In contrast to canonical hexokinases, which use ATP, ADP-dependent glucokinase (ADPGK) catalyzes noncanonical phosphorylation of glucose to glucose 6-phosphate using ADP as a phosphate donor.	Glucose	129-136	ADP dependent glucokinase	Homo sapiens	53-78
29784881-2	2018	In contrast to canonical hexokinases, which use ATP, ADP-dependent glucokinase (ADPGK) catalyzes noncanonical phosphorylation of glucose to glucose 6-phosphate using ADP as a phosphate donor.	Glucose	129-136	ADP dependent glucokinase	Homo sapiens	80-85
29784881-2	2018	In contrast to canonical hexokinases, which use ATP, ADP-dependent glucokinase (ADPGK) catalyzes noncanonical phosphorylation of glucose to glucose 6-phosphate using ADP as a phosphate donor.	Glucose-6-Phosphate	140-159	ADP dependent glucokinase	Homo sapiens	53-78
29784881-2	2018	In contrast to canonical hexokinases, which use ATP, ADP-dependent glucokinase (ADPGK) catalyzes noncanonical phosphorylation of glucose to glucose 6-phosphate using ADP as a phosphate donor.	Glucose-6-Phosphate	140-159	ADP dependent glucokinase	Homo sapiens	80-85
29784881-2	2018	In contrast to canonical hexokinases, which use ATP, ADP-dependent glucokinase (ADPGK) catalyzes noncanonical phosphorylation of glucose to glucose 6-phosphate using ADP as a phosphate donor.	Adenosine Diphosphate	53-56	ADP dependent glucokinase	Homo sapiens	80-85
29784881-2	2018	In contrast to canonical hexokinases, which use ATP, ADP-dependent glucokinase (ADPGK) catalyzes noncanonical phosphorylation of glucose to glucose 6-phosphate using ADP as a phosphate donor.	Phosphates	150-159	ADP dependent glucokinase	Homo sapiens	53-78
29784881-2	2018	In contrast to canonical hexokinases, which use ATP, ADP-dependent glucokinase (ADPGK) catalyzes noncanonical phosphorylation of glucose to glucose 6-phosphate using ADP as a phosphate donor.	Phosphates	150-159	ADP dependent glucokinase	Homo sapiens	80-85
29784881-6	2018	Here, we show that 8-bromo-substituted adenosine nucleotide inhibits human ADPGK.	8-bromo-substituted adenosine nucleotide	19-59	ADP dependent glucokinase	Homo sapiens	75-80
29784881-7	2018	By solving the crystal structure of archaeal ADPGK in complex with 8-bromoadenosine phosphate (8-Br-AMP) at 1.81 A resolution, we identified the mechanism of inhibition.	8-bromoadenosine phosphate	67-93	ADP dependent glucokinase	Homo sapiens	45-50
29784881-7	2018	By solving the crystal structure of archaeal ADPGK in complex with 8-bromoadenosine phosphate (8-Br-AMP) at 1.81 A resolution, we identified the mechanism of inhibition.	8-Bromoadenosine 5'-monophosphate	95-103	ADP dependent glucokinase	Homo sapiens	45-50
29784881-8	2018	We observed that 8-Br-AMP is a competitive inhibitor of ADPGK and that the bromine substitution induces marked structural changes within the protein"s active site by engaging crucial catalytic residues.	8-Bromoadenosine 5'-monophosphate	17-25	ADP dependent glucokinase	Homo sapiens	56-61
29784881-8	2018	We observed that 8-Br-AMP is a competitive inhibitor of ADPGK and that the bromine substitution induces marked structural changes within the protein"s active site by engaging crucial catalytic residues.	Bromine	75-82	ADP dependent glucokinase	Homo sapiens	56-61
27173608-4	2016	ADP, one of the cycling reaction products, was distinguished from IDP by using the nucleotide selectivity of the ADP-GK.	Adenosine Diphosphate	0-3	ADP dependent glucokinase	Homo sapiens	113-119
23799003-3	2013	The hypothesis we tested is that ADPGK utilises ADP to phosphorylate glucose under conditions where ATP becomes limiting, such as hypoxia.	Glucose	69-76	ADP dependent glucokinase	Homo sapiens	33-38
23799003-3	2013	The hypothesis we tested is that ADPGK utilises ADP to phosphorylate glucose under conditions where ATP becomes limiting, such as hypoxia.	Adenosine Triphosphate	100-103	ADP dependent glucokinase	Homo sapiens	33-38
23799003-11	2013	However, oxygen consumption rates were generally lower in the ADPGK knockouts, in some cases markedly so.	Oxygen	9-15	ADP dependent glucokinase	Homo sapiens	62-67
22219026-4	2012	Recombinant human ADPGK was confirmed to catalyse ADP-dependent glucose phosphorylation in vitro, with an apparent K (M) for glucose of 0.29 mM.	Glucose	64-71	ADP dependent glucokinase	Homo sapiens	18-23
22219026-4	2012	Recombinant human ADPGK was confirmed to catalyse ADP-dependent glucose phosphorylation in vitro, with an apparent K (M) for glucose of 0.29 mM.	Glucose	125-132	ADP dependent glucokinase	Homo sapiens	18-23
22219026-10	2012	Thus, human ADPGK catalyses ADP-dependent phosphorylation of glucose in vitro, but despite its high expression in human tumour cell lines it appears not to make a quantifiable contribution to glycolysis under the conditions evaluated.	Glucose	61-68	ADP dependent glucokinase	Homo sapiens	12-17