PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 2427448-0 1986 [Volume replacement with a new hydroxyethyl starch preparation (3 percent HES 200/0.5) in heart surgery]. Hydroxyethyl starch 31-50 ribosome binding protein 1 Homo sapiens 74-77 2482677-0 1989 [Effects of low molecular weight hydroxyethyl starch (HES 40) in comparison with Ringer solution on oxygen tension in skeletal muscles of infected patients]. Hydroxyethyl starch 33-52 ribosome binding protein 1 Homo sapiens 54-57 2482677-0 1989 [Effects of low molecular weight hydroxyethyl starch (HES 40) in comparison with Ringer solution on oxygen tension in skeletal muscles of infected patients]. Oxygen 100-106 ribosome binding protein 1 Homo sapiens 54-57 3263155-8 1988 PaO2 increased significantly (P less than 0.05) compared with preinfusion or the control group (infused with same dose of HES). pao2 0-4 ribosome binding protein 1 Homo sapiens 122-125 2447539-1 1987 The usefulness of 99Tcm hydroxyethyl starch (99Tcm HES) has been evaluated for visualization of lymphatic channels and lymph nodes. Hydroxyethyl starch 24-43 ribosome binding protein 1 Homo sapiens 51-54 2427448-1 1986 In a randomized study including 55 patients undergoing elective aorto-coronary bypass surgery efficacy of a low concentrated hydroxyethylstarch (3% HES 200/0.5) was tested after extracorporeal circulation (ECC). hydroxyethylstarch 125-143 ribosome binding protein 1 Homo sapiens 148-151 2427448-6 1986 EVLW-measurement demonstrated the lowest increase in lung water after infusion of HES; simultaneously pulmonary gas exchange was less compromised in comparison to the other infusion groups. Water 58-63 ribosome binding protein 1 Homo sapiens 82-85 2423457-0 1986 [Reactions of critically ill patients to volume therapy with hydroxyethyl starch (6% HES 450/0.7)]. Hydroxyethyl starch 61-80 ribosome binding protein 1 Homo sapiens 85-88 2422795-1 1986 Currently, the frequency of granulocyte donation is limited by the prolonged circulation of hydroxyethyl starch (HES). Hydroxyethyl starch 92-111 ribosome binding protein 1 Homo sapiens 113-116 6208407-1 1984 Three adult dialysis patients developed ascites after having received repeatedly the plasma substitute hydroxyethyl starch (HES 40/0.5). Hydroxyethyl starch 103-122 ribosome binding protein 1 Homo sapiens 124-127 6165740-3 1981 Gel filtration of Sepharose CL-4B revealed that aliquots of urine collected 1 hour after injection contained polymer fragments of HES 350/0.60 with values of Kav ranging between 0.88 and 0.84, and possessed a Stokes radius (r = 32A) similar to that of Dextran 20 (M-W 22 700). Sepharose CL 4B 18-33 ribosome binding protein 1 Homo sapiens 130-133 6165740-4 1981 Polymer fragments of HES 350/0.60 excreted 6 to 48 hours after dosing, however, possessed a Kav ranging between 0.78 and 0.73 with a Stokes radius (r = 45A) similar to that of Dextran 40 (M-W 41 000). Dextrans 176-186 ribosome binding protein 1 Homo sapiens 21-24 6165740-7 1981 This study, in conjunction with our previous investigation of the changes in circulating HES 350/0.60, define the basic differences between clearance and excretion of the dextrans and of the rapidly degraded species of HES. Dextrans 171-179 ribosome binding protein 1 Homo sapiens 89-92 67228-0 1977 [Volume changes of extravascular lung water by plasma expander (HES) infusion]. Water 38-43 ribosome binding protein 1 Homo sapiens 64-67 6161272-4 1980 Intact GG are obtained by beta-propiolactone treatment, acidification at pH or precipitation with polyethylenglycol-hydroxyethylstarch (PEG/HES). polyethylenglycol-hydroxyethylstarch 98-134 ribosome binding protein 1 Homo sapiens 140-143 93347-1 1979 A low-molecular-weight preparation of hydroxyethyl starch (LMW-HES) may serve as a desirable substitute for the erythrocyte sedimenting agents presently employed to improve neutrophil yields in centrifugation and gravity leukapheresis. Hydroxyethyl starch 38-57 ribosome binding protein 1 Homo sapiens 63-66 31357893-4 2019 Based on it, this paper builds HES-TG100-115-CDM-PEG micelles with tumor microenvironment responsiveness that simultaneously loaded sorafenib and TG100-115 to synergistically treat liver cancer. Chlorphenamidine 45-48 ribosome binding protein 1 Homo sapiens 31-34 33304917-9 2020 Besides, overweight/obesity and alcohol drinking were associated with lower HES scores. Alcohols 32-39 ribosome binding protein 1 Homo sapiens 76-79 32689756-1 2020 Objective: To investigate the effect of 6% hydroxyethyl starch 130/0.4(HES) on protein in severe trauma orthopedic patients after acute hemodilution. Hydroxyethyl starch 43-62 ribosome binding protein 1 Homo sapiens 71-74 32689756-14 2020 HES could bind to Trp-214 residue in HSA at a molecular ration of 1:1. Tryptophan 18-21 ribosome binding protein 1 Homo sapiens 0-3 32689756-16 2020 HES could bind to Trp-214 amino acid residue in HSA and form the complex at a molecular ratio of 1:1. Tryptophan 18-21 ribosome binding protein 1 Homo sapiens 0-3 32289433-4 2020 In this research, we tried to identify whether regulating E2F1/RRBP1 pathway could inhibit the proliferation and metastasis of HepG2 cells induced by high glucose. Glucose 155-162 ribosome binding protein 1 Homo sapiens 63-68 53917-2 1975 The addition of HES alone or in combination with either etiocholanolone or dexamethasone, resulted in a significant increase in the numbers of leukocytes (granulocytes) harvested by continuous and noncontinuous flow centrifugation. Dexamethasone 75-88 ribosome binding protein 1 Homo sapiens 16-19 33963301-0 2021 Correction: RRBP1 rewires cisplatin resistance in oral squamous cell carcinoma by regulating Hippo pathway. Cisplatin 26-35 ribosome binding protein 1 Homo sapiens 12-17 31357893-4 2019 Based on it, this paper builds HES-TG100-115-CDM-PEG micelles with tumor microenvironment responsiveness that simultaneously loaded sorafenib and TG100-115 to synergistically treat liver cancer. Polyethylene Glycols 49-52 ribosome binding protein 1 Homo sapiens 31-34 31357893-4 2019 Based on it, this paper builds HES-TG100-115-CDM-PEG micelles with tumor microenvironment responsiveness that simultaneously loaded sorafenib and TG100-115 to synergistically treat liver cancer. Sorafenib 132-141 ribosome binding protein 1 Homo sapiens 31-34 31357893-8 2019 These findings reveal that HES-TG100-115-CDM-PEG micelles are a promising drug delivery system in clinical comprehensive therapy of liver cancer. Chlorphenamidine 41-44 ribosome binding protein 1 Homo sapiens 27-30 31357893-8 2019 These findings reveal that HES-TG100-115-CDM-PEG micelles are a promising drug delivery system in clinical comprehensive therapy of liver cancer. Polyethylene Glycols 45-48 ribosome binding protein 1 Homo sapiens 27-30 31223113-6 2019 Baicalin (200 mug/mL) significantly promoted the apoptosis of keratinocytes, arrested the S phase, inhibited the mRNA expression of ki67, increased the Fas and caspase-3 levels, down-regulated the protein expression of Jagged 1, and up-regulated the Notch 1 and Hes protein levels. baicalin 0-8 ribosome binding protein 1 Homo sapiens 262-265 31824950-5 2019 Similarly, hES cells require methionine (Met) to maintain the Met-SAM (S-adenosyl methionine) cycle of 1-carbon metabolism also for H3K4me3 formation. Methionine 29-39 ribosome binding protein 1 Homo sapiens 11-14 31824950-5 2019 Similarly, hES cells require methionine (Met) to maintain the Met-SAM (S-adenosyl methionine) cycle of 1-carbon metabolism also for H3K4me3 formation. Methionine 41-44 ribosome binding protein 1 Homo sapiens 11-14 31824950-5 2019 Similarly, hES cells require methionine (Met) to maintain the Met-SAM (S-adenosyl methionine) cycle of 1-carbon metabolism also for H3K4me3 formation. Methionine 62-65 ribosome binding protein 1 Homo sapiens 11-14 31824950-5 2019 Similarly, hES cells require methionine (Met) to maintain the Met-SAM (S-adenosyl methionine) cycle of 1-carbon metabolism also for H3K4me3 formation. adenosyl-methionine 1,4-butanedisulfonate 71-92 ribosome binding protein 1 Homo sapiens 11-14 31824950-5 2019 Similarly, hES cells require methionine (Met) to maintain the Met-SAM (S-adenosyl methionine) cycle of 1-carbon metabolism also for H3K4me3 formation. Carbon 103-111 ribosome binding protein 1 Homo sapiens 11-14 31824950-5 2019 Similarly, hES cells require methionine (Met) to maintain the Met-SAM (S-adenosyl methionine) cycle of 1-carbon metabolism also for H3K4me3 formation. H-2K(K) antigen 132-139 ribosome binding protein 1 Homo sapiens 11-14 31824950-6 2019 H3K4me3 is needed specifically to regulate and maintain both mES and hES cell proliferation and their pluripotent states. H-2K(K) antigen 0-7 ribosome binding protein 1 Homo sapiens 69-72 31824950-8 2019 Furthermore, since ES cells are derived from their progenitor cells in preimplantation blastocysts, they serve as models of 1-carbon metabolism in these precursors of all mammalian tissues and organs. Carbon 124-132 ribosome binding protein 1 Homo sapiens 19-21 31824950-10 2019 These 1-carbon metabolism challenges result in altered epigenetic DNA and histone modifications in ES progenitor cells and the tissues and organs to which they develop. Carbon 6-14 ribosome binding protein 1 Homo sapiens 99-101 30940724-6 2019 Cleaved NOTCH1, HES1 (Hes family BHLH transcription factor 1), and c-MYC protein expression levels are elevated in two enzalutamide-resistant cell lines, MR49F and C4-2R, indicating NOTCH signaling activation. enzalutamide 119-131 ribosome binding protein 1 Homo sapiens 22-25 30152680-1 2018 We report two new regioregular and regioirregular model copolymer acceptors based on selenophene and perylenetetracarboxylic diimide moieties, respectively, named RR-P(SePDI) and RI-P(SePDI), which were synthesized to study how regioregularity impacts the properties of resulting polymers. copolymer 56-65 ribosome binding protein 1 Homo sapiens 163-174 30152680-1 2018 We report two new regioregular and regioirregular model copolymer acceptors based on selenophene and perylenetetracarboxylic diimide moieties, respectively, named RR-P(SePDI) and RI-P(SePDI), which were synthesized to study how regioregularity impacts the properties of resulting polymers. Polymers 280-288 ribosome binding protein 1 Homo sapiens 163-174 30684972-4 2019 METHODS: We investigated the expression of RRBP1 protein by immunohistochemistry on paraffin-embedded surgical specimens from one hundred thirty patients with endometrioid-type endometrial carcinoma. Paraffin 84-92 ribosome binding protein 1 Homo sapiens 43-48 30152680-1 2018 We report two new regioregular and regioirregular model copolymer acceptors based on selenophene and perylenetetracarboxylic diimide moieties, respectively, named RR-P(SePDI) and RI-P(SePDI), which were synthesized to study how regioregularity impacts the properties of resulting polymers. Selenophene 85-96 ribosome binding protein 1 Homo sapiens 163-174 28485785-0 2017 Study on the influence of metformin on castration-resistant prostate cancer PC-3 cell line biological behavior by its inhibition on PLCepsilon gene-mediated Notch1/Hes and androgen receptor signaling pathway. Metformin 26-35 ribosome binding protein 1 Homo sapiens 164-167 28645575-6 2017 Treatment with acetaminophen significantly elevated the levels of inflammatory cytokines by hES-HLCs. Acetaminophen 15-28 ribosome binding protein 1 Homo sapiens 92-95 28645575-7 2017 Moreover, three human immune cell lines, Jurkat, THP-1, and NK92MI, were activated when cultured in conditioned medium obtained from acetaminophen-treated hES-HLCs. Acetaminophen 133-146 ribosome binding protein 1 Homo sapiens 155-158 28485785-1 2017 OBJECTIVE: To study the regulation of metformin on the biological behaviors of the castration-resistant prostate cancer (CRPC) PC-3 cell such as proliferation, invasion, apoptosis through influencing Notch1/Hes and androgen receptor (AR) signaling pathway activity by its inhibition on the expression of PLCepsilon gene. Metformin 38-47 ribosome binding protein 1 Homo sapiens 207-210 28485785-10 2017 CONCLUSIONS: Metformin can regulate the biological behaviors of CRPC PC-3 cell line such as proliferation, invasion, migration and apoptosis through influencing Notch1/Hes and AR signaling pathway activity by its inhibition on the expression of PLCepsilon gene. Metformin 13-22 ribosome binding protein 1 Homo sapiens 168-171 27447629-6 2016 Moreover, the RRBP1 expression is induced by chemotherapeutic drug paclitaxel or adriamycin in human hepatocellular carcinoma cells and accompanied with the increased expression of La autoantigen (La), which binds to RRBP1 IRES element and facilitates translation initiation. Paclitaxel 67-77 ribosome binding protein 1 Homo sapiens 14-19 27447629-6 2016 Moreover, the RRBP1 expression is induced by chemotherapeutic drug paclitaxel or adriamycin in human hepatocellular carcinoma cells and accompanied with the increased expression of La autoantigen (La), which binds to RRBP1 IRES element and facilitates translation initiation. Doxorubicin 81-91 ribosome binding protein 1 Homo sapiens 14-19 29404138-6 2016 We herein report a patient with "complex undefined HES" who had disease resistant to corticosteroids, but who had a significant response after treatment with imatinib. Imatinib Mesylate 158-166 ribosome binding protein 1 Homo sapiens 51-55 27800134-13 2016 CONCLUSIONS: The obtained results indicate that RSM is an effective method for the optimization of culture conditions for hES gene expression in E. coli. (2s)-2-(Acetylamino)-N-Methyl-4-[(R)-Methylsulfinyl]butanamide 48-51 ribosome binding protein 1 Homo sapiens 122-125 26069023-3 2016 Here, we describe a simple and efficient method for the cryopreservation of hES/hiPS cells that is based on a conventional slow freezing method that uses a combination of Pronase/EDTA for Stem and CP-5E [final concentrations: 6 % hydroxyethyl starch, 5 % DMSO, and 5 % ethylene glycol in saline]. Edetic Acid 179-183 ribosome binding protein 1 Homo sapiens 76-79 26769970-9 2016 In addition, GCNF also showed a regulatory gene pattern that is different from RA treatment during hES cell differentiation. Radium 79-81 ribosome binding protein 1 Homo sapiens 99-102 26069023-3 2016 Here, we describe a simple and efficient method for the cryopreservation of hES/hiPS cells that is based on a conventional slow freezing method that uses a combination of Pronase/EDTA for Stem and CP-5E [final concentrations: 6 % hydroxyethyl starch, 5 % DMSO, and 5 % ethylene glycol in saline]. cp-5e 198-203 ribosome binding protein 1 Homo sapiens 76-79 26069023-3 2016 Here, we describe a simple and efficient method for the cryopreservation of hES/hiPS cells that is based on a conventional slow freezing method that uses a combination of Pronase/EDTA for Stem and CP-5E [final concentrations: 6 % hydroxyethyl starch, 5 % DMSO, and 5 % ethylene glycol in saline]. Hydroxyethyl starch 232-251 ribosome binding protein 1 Homo sapiens 76-79 26069023-3 2016 Here, we describe a simple and efficient method for the cryopreservation of hES/hiPS cells that is based on a conventional slow freezing method that uses a combination of Pronase/EDTA for Stem and CP-5E [final concentrations: 6 % hydroxyethyl starch, 5 % DMSO, and 5 % ethylene glycol in saline]. Dimethyl Sulfoxide 257-261 ribosome binding protein 1 Homo sapiens 76-79 26069023-3 2016 Here, we describe a simple and efficient method for the cryopreservation of hES/hiPS cells that is based on a conventional slow freezing method that uses a combination of Pronase/EDTA for Stem and CP-5E [final concentrations: 6 % hydroxyethyl starch, 5 % DMSO, and 5 % ethylene glycol in saline]. Ethylene Glycol 271-286 ribosome binding protein 1 Homo sapiens 76-79 26069023-3 2016 Here, we describe a simple and efficient method for the cryopreservation of hES/hiPS cells that is based on a conventional slow freezing method that uses a combination of Pronase/EDTA for Stem and CP-5E [final concentrations: 6 % hydroxyethyl starch, 5 % DMSO, and 5 % ethylene glycol in saline]. Sodium Chloride 290-296 ribosome binding protein 1 Homo sapiens 76-79 26069023-4 2016 CP-5E is highly effective for the cryopreservation of small cell clumps produced by hES/hiPS colony detachment in the presence of Pronase and EDTA (Pronase/EDTA for Stem , a formulation containing multiple digestive enzymes from Streptomyces griseus). cp-5e 0-5 ribosome binding protein 1 Homo sapiens 85-88 26323587-1 2015 The present study is the first to demonstrate the anticancer effects of a hexane extract from the brown algae Sargassum serratifolium (HES) on human cancer cell lines, including glioblastoma U87MG, cervical cancer HeLa and gastric cancer MKN-28 cells, as well as liver cancer SK-HEP 1 cells. Hexanes 74-80 ribosome binding protein 1 Homo sapiens 135-138 27247576-8 2016 Exposure of hES cells to lovastatin led to a minor decrease in the expression of SSEA-3 and a significant reduction in CD133 expression. Lovastatin 25-35 ribosome binding protein 1 Homo sapiens 12-15 27247576-11 2016 In conclusion, lovastatin reduced the heterogeneity of hES cells and impaired their differentiation potential. Lovastatin 15-25 ribosome binding protein 1 Homo sapiens 55-58 26159831-2 2015 It has previously been determined that oxygen regulates human embryonic stem (hES) cell glycolytic and amino acid metabolism, but the effects on mitochondria are as yet unknown. Oxygen 39-45 ribosome binding protein 1 Homo sapiens 78-81 26159831-4 2015 In response to extended physiological oxygen culture, MEL2 hES cells displayed reduced mtDNA content, mitochondrial mass and expression of metabolic genes TFAM, NRF1, PPARa and MT-ND4. Oxygen 38-44 ribosome binding protein 1 Homo sapiens 59-62 26159831-5 2015 Furthermore, MEL2 hES cell glucose consumption, lactate production and amino acid turnover were elevated under physiological oxygen. Glucose 27-34 ribosome binding protein 1 Homo sapiens 18-21 26159831-5 2015 Furthermore, MEL2 hES cell glucose consumption, lactate production and amino acid turnover were elevated under physiological oxygen. Lactic Acid 48-55 ribosome binding protein 1 Homo sapiens 18-21 26159831-5 2015 Furthermore, MEL2 hES cell glucose consumption, lactate production and amino acid turnover were elevated under physiological oxygen. Oxygen 125-131 ribosome binding protein 1 Homo sapiens 18-21 26159831-8 2015 Here we report the first incidence of metabolic dysfunction in a hES cell population, defined as a failure to respond to oxygen concentration through the modulation of metabolism, demonstrating that hES cells can be perturbed during culture despite exhibiting the defining characteristics of pluripotent cells. Oxygen 121-127 ribosome binding protein 1 Homo sapiens 65-68 26159831-9 2015 Collectively, these data reveal a central role for oxygen in the regulation of hES cell metabolism and mitochondrial function, whereby physiological oxygen promotes glucose flux and suppresses mitochondrial biogenesis and gene expression. Oxygen 51-57 ribosome binding protein 1 Homo sapiens 79-82 26159831-9 2015 Collectively, these data reveal a central role for oxygen in the regulation of hES cell metabolism and mitochondrial function, whereby physiological oxygen promotes glucose flux and suppresses mitochondrial biogenesis and gene expression. Oxygen 149-155 ribosome binding protein 1 Homo sapiens 79-82 26159831-9 2015 Collectively, these data reveal a central role for oxygen in the regulation of hES cell metabolism and mitochondrial function, whereby physiological oxygen promotes glucose flux and suppresses mitochondrial biogenesis and gene expression. Glucose 165-172 ribosome binding protein 1 Homo sapiens 79-82 23295012-5 2014 Manipulation of Notch signaling can boost or suppress neural differentiation of hES cell derivatives, suggesting that Notch signaling may underlie the PA6-mediated neural induction. (R)-2-(Formyloxy)-3-(Phosphonooxy)propyl Pentanoate 151-154 ribosome binding protein 1 Homo sapiens 80-83 24838295-3 2015 However, to what extent MMC affects the karyotypic stability of hES cells is not clear. Mitomycin 24-27 ribosome binding protein 1 Homo sapiens 64-67 24838295-9 2015 Therefore, MMC-feeder and MMC-induced genomic variation present an important safety problem that would limit such hES from being applied for future clinic use and drug screening. Mitomycin 11-14 ribosome binding protein 1 Homo sapiens 114-117 26170169-10 2015 These results highlight key differences between direct and indirect exposure of hES cells across a trophoblast barrier to metal toxins. Metals 122-127 ribosome binding protein 1 Homo sapiens 80-83 25458454-12 2014 HES 130/0.4 coload reduced the incidence, the duration of longest hypotension, the need for ephedrine and the adverse maternal effects. Ephedrine 92-101 ribosome binding protein 1 Homo sapiens 0-3 23295012-9 2014 This study suggested the potential of utilizing PA6 coculture to imitate the embryonic niche for hES cell neural induction via Notch signaling and a high application potential of BMSC-involved protocol, which can yield a whole lineage of human neural cells to promote endogenous regeneration in the hippocampus upon transplantation for potential therapy of ischemic stroke. (R)-2-(Formyloxy)-3-(Phosphonooxy)propyl Pentanoate 48-51 ribosome binding protein 1 Homo sapiens 97-100 22668504-5 2012 Moreover, we isolated and identified 20-hydroxyecdysone (20-HES) as a marker component in FAJN. Ecdysterone 37-55 ribosome binding protein 1 Homo sapiens 60-63 23318453-11 2013 Ectopic expression of RRBP1 alleviated apoptosis that was induced by the ER-stress agent tunicamycin, 2-deoxy-D-glucose (2DG) or doxorubicin via enhancing GRP78 protein expression. Tunicamycin 89-100 ribosome binding protein 1 Homo sapiens 22-27 23318453-11 2013 Ectopic expression of RRBP1 alleviated apoptosis that was induced by the ER-stress agent tunicamycin, 2-deoxy-D-glucose (2DG) or doxorubicin via enhancing GRP78 protein expression. Deoxyglucose 102-119 ribosome binding protein 1 Homo sapiens 22-27 23318453-11 2013 Ectopic expression of RRBP1 alleviated apoptosis that was induced by the ER-stress agent tunicamycin, 2-deoxy-D-glucose (2DG) or doxorubicin via enhancing GRP78 protein expression. Deoxyglucose 121-124 ribosome binding protein 1 Homo sapiens 22-27 23318453-11 2013 Ectopic expression of RRBP1 alleviated apoptosis that was induced by the ER-stress agent tunicamycin, 2-deoxy-D-glucose (2DG) or doxorubicin via enhancing GRP78 protein expression. Doxorubicin 129-140 ribosome binding protein 1 Homo sapiens 22-27 23623797-6 2013 Addition of sucrose to HES decreases free volume, but the effect of trehalose is not detectable above experimental error. Sucrose 12-19 ribosome binding protein 1 Homo sapiens 23-26 23623797-7 2013 Addition of sorbitol or glycerol to HES/trehalose base formulations appears to significantly decrease free volume, consistent with the positive impact of such additions on pharmaceutical stability (i.e., degradation) in the glassy state. Sorbitol 12-20 ribosome binding protein 1 Homo sapiens 36-39 23623797-7 2013 Addition of sorbitol or glycerol to HES/trehalose base formulations appears to significantly decrease free volume, consistent with the positive impact of such additions on pharmaceutical stability (i.e., degradation) in the glassy state. Glycerol 24-32 ribosome binding protein 1 Homo sapiens 36-39 23623797-10 2013 Global mobility as measured by enthalpy relaxation times, increases as disaccharides, particularly sucrose, are added to HES. Disaccharides 71-84 ribosome binding protein 1 Homo sapiens 121-124 23623797-10 2013 Global mobility as measured by enthalpy relaxation times, increases as disaccharides, particularly sucrose, are added to HES. Sucrose 99-106 ribosome binding protein 1 Homo sapiens 121-124 25477962-2 2014 In this study we investigated the effects of the small molecular agent NU6140 (inhibits CDK2 and cyclin A interaction) on human embryonic stem (hES) cells and embryonal carcinoma-derived (hEC) cells via the expression of transcription factors responsible for pluripotency. 4-(6-cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide 71-77 ribosome binding protein 1 Homo sapiens 144-147 25477962-4 2014 Both hES and hEC cells responded to NU6140 treatment by induced apoptosis and a decreased expression of NANOG, OCT4, and SOX2 in surviving cells. 4-(6-cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide 36-42 ribosome binding protein 1 Homo sapiens 5-8 25477962-5 2014 A higher sensitivity to NU6140 application in hES than hEC cells was detected. 4-(6-cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide 24-30 ribosome binding protein 1 Homo sapiens 46-49 25477962-6 2014 NU6140 treatment arrested hES and hEC cells in the G2 phase and inhibited entry into the M phase as evidenced by no significant increase in histone 3 phosphorylation. 4-(6-cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide 0-6 ribosome binding protein 1 Homo sapiens 26-29 25477962-7 2014 When embryoid bodies (EBs) formed from NU6104 treated hES cells were compared to EBs from untreated hES cells differences in ectodermal, endodermal, and mesodermal lineages were found. nu6104 39-45 ribosome binding protein 1 Homo sapiens 54-57 24028740-4 2013 RESULTS: In this study, we evaluated the stability of various references during retinoic acid-induced (2 microM) differentiation of hES cells. Tretinoin 80-93 ribosome binding protein 1 Homo sapiens 132-135 23926905-11 2013 iii) CHEST randomized ICU patients to receive saline or 6% HES 130/0.4 for fluid resuscitation. Sodium Chloride 46-52 ribosome binding protein 1 Homo sapiens 6-9 23005914-5 2012 By tailoring the peptide displayed to cells and the substrate mechanical properties, a hydrogel was generated that binds hES cell surface glycosaminoglycans (GAGs) and functions robustly in a defined culture medium to support long-term hES cell self-renewal. Glycosaminoglycans 138-156 ribosome binding protein 1 Homo sapiens 121-124 23005914-5 2012 By tailoring the peptide displayed to cells and the substrate mechanical properties, a hydrogel was generated that binds hES cell surface glycosaminoglycans (GAGs) and functions robustly in a defined culture medium to support long-term hES cell self-renewal. Glycosaminoglycans 138-156 ribosome binding protein 1 Homo sapiens 236-239 23005914-5 2012 By tailoring the peptide displayed to cells and the substrate mechanical properties, a hydrogel was generated that binds hES cell surface glycosaminoglycans (GAGs) and functions robustly in a defined culture medium to support long-term hES cell self-renewal. Glycosaminoglycans 158-162 ribosome binding protein 1 Homo sapiens 121-124 23005914-5 2012 By tailoring the peptide displayed to cells and the substrate mechanical properties, a hydrogel was generated that binds hES cell surface glycosaminoglycans (GAGs) and functions robustly in a defined culture medium to support long-term hES cell self-renewal. Glycosaminoglycans 158-162 ribosome binding protein 1 Homo sapiens 236-239 23091637-11 2012 CONCLUSIONS: hES-derived OPCs transplanted 2 hours after contusive SCI survive and differentiate into OLs that produce MBP. N-biotin-C-Co4(mu3-O)4(Py)4(H2O)4-beta-alanine 102-105 ribosome binding protein 1 Homo sapiens 13-16 22227454-7 2012 By using the SDIA method, we induced dopaminergic (DA) neurons by coculturing HLA-G1-H1 hES cells with the mouse stromal cell line PA6. sdia 13-17 ribosome binding protein 1 Homo sapiens 88-91 22158523-4 2012 HUVEC cell migration and tube-formation assays suggested that MC-mediated endostatin gene has significant anti-migration and anti-tube-formation capacity than that in pcDNA-hES. Methylcholanthrene 62-64 ribosome binding protein 1 Homo sapiens 173-176 22464164-10 2012 CONCLUSION: HES 130/0.4 preload reduced the incidence of hypotension, the duration of longest hypotension, and the need for ephedrine during spinal anaesthesia for elective caesarean section. Ephedrine 124-133 ribosome binding protein 1 Homo sapiens 12-15 21744479-9 2012 The HES2 and HES5 gene promoters were found to be heavily methylated in most neuroblastoma lines, and HES gene expression could be induced through treatment with decitabine. Decitabine 162-172 ribosome binding protein 1 Homo sapiens 4-7 21744479-12 2012 HES gene expression appears to be regulated epigenetically and could be induced with decitabine. Decitabine 85-95 ribosome binding protein 1 Homo sapiens 0-3 20735361-3 2011 The hES-T3 cells with normal female karyotype were first differentiated into EBs (embryoid bodies) and then induced to generate the T3pi (pancreatic islet-like cell clusters derived from T3 cells), which expressed pancreatic islet cell-specific markers of insulin, glucagon and somatostatin. t3pi 132-136 ribosome binding protein 1 Homo sapiens 4-7 21857015-8 2011 In blunt trauma (n=42), there was no difference in study fluid requirements, but the HES group required significantly more blood products [packed red blood cell volumes 2943 (1628) vs 1473 (1071) ml, P=0.005] and was more severely injured than the saline group (median injury severity score 29.5 vs 18; P=0.01). Sodium Chloride 248-254 ribosome binding protein 1 Homo sapiens 85-88 21857015-9 2011 Haemodynamic data were similar, but, in the penetrating group, plasma lactate concentrations were lower over the first 4 h (P=0.029) and on day 1 with HES than with saline [2.1 (1.4) vs 3.2 (2.2) mmol litre-1; P=0.017]. Lactic Acid 70-77 ribosome binding protein 1 Homo sapiens 151-154 21857015-14 2011 CONCLUSIONS: In penetrating trauma, HES provided significantly better lactate clearance and less renal injury than saline. Lactic Acid 70-77 ribosome binding protein 1 Homo sapiens 36-39 21284604-2 2011 Previously, we reported that PLD1 (phospholipase D1) plays an important role in cAMP-induced decidualization of hES cells. Cyclic AMP 80-84 ribosome binding protein 1 Homo sapiens 112-115 20735361-3 2011 The hES-T3 cells with normal female karyotype were first differentiated into EBs (embryoid bodies) and then induced to generate the T3pi (pancreatic islet-like cell clusters derived from T3 cells), which expressed pancreatic islet cell-specific markers of insulin, glucagon and somatostatin. Glucagon 265-273 ribosome binding protein 1 Homo sapiens 4-7 20952347-9 2010 Furthermore we saw a significant decrease in platelet function in the HES 200/0.5 group when performing the multiplate-analysis (ADP-and COL-test). Adenosine Diphosphate 129-132 ribosome binding protein 1 Homo sapiens 70-73 21431516-3 2011 In our hands, trypsinizing hES into single cells and plating them on gelatin coated plates in a DMEM medium supplemented with serum replacement media and FGF2 with either PDGF AB or EGF will induce differentiation of hES and selectively enhance the survival of MSCs over hES. dmem medium 96-107 ribosome binding protein 1 Homo sapiens 217-220 21431516-3 2011 In our hands, trypsinizing hES into single cells and plating them on gelatin coated plates in a DMEM medium supplemented with serum replacement media and FGF2 with either PDGF AB or EGF will induce differentiation of hES and selectively enhance the survival of MSCs over hES. dmem medium 96-107 ribosome binding protein 1 Homo sapiens 27-30 21431516-3 2011 In our hands, trypsinizing hES into single cells and plating them on gelatin coated plates in a DMEM medium supplemented with serum replacement media and FGF2 with either PDGF AB or EGF will induce differentiation of hES and selectively enhance the survival of MSCs over hES. dmem medium 96-107 ribosome binding protein 1 Homo sapiens 217-220 20367256-6 2010 In addition, treatment with dimethyl sulfoxide further increased the transfection efficiency of hES cells. Dimethyl Sulfoxide 28-46 ribosome binding protein 1 Homo sapiens 96-99 20952347-11 2010 The gelatin-group and the HES 200/0.5 needed significantly more aprotinine than the HES 130/0.4 group. Iniprol 64-74 ribosome binding protein 1 Homo sapiens 26-29 20043754-1 2010 Human embryonic stem (hES) cell differentiation into dopamine neurons is considered a promising strategy for cell replacement therapy in Parkinson"s disease, yet the functional properties of hES cell-derived dopamine neurons remain poorly defined. Dopamine 53-61 ribosome binding protein 1 Homo sapiens 22-25 20043754-2 2010 The objective of this study was to characterize intracellular calcium (Ca(2+)) and sub-plasma membrane cyclic AMP-signaling properties in hES cell-derived dopamine neurons. Calcium 62-69 ribosome binding protein 1 Homo sapiens 138-141 20043754-2 2010 The objective of this study was to characterize intracellular calcium (Ca(2+)) and sub-plasma membrane cyclic AMP-signaling properties in hES cell-derived dopamine neurons. Cyclic AMP 103-113 ribosome binding protein 1 Homo sapiens 138-141 20043754-2 2010 The objective of this study was to characterize intracellular calcium (Ca(2+)) and sub-plasma membrane cyclic AMP-signaling properties in hES cell-derived dopamine neurons. Dopamine 155-163 ribosome binding protein 1 Homo sapiens 138-141 20512122-1 2010 We report a fully defined synthetic polymer coating, poly[2-(methacryloyloxy)ethyl dimethyl-(3-sulfopropyl)ammonium hydroxide] (PMEDSAH), which sustains long-term human embryonic stem (hES) cell growth in several different culture media, including commercially available defined media. Polymers 36-43 ribosome binding protein 1 Homo sapiens 185-188 20043754-3 2010 We found that hES cell-derived dopamine neurons and neural progenitors raised Ca(2+) from intra- and extracellular compartments in response to depolarization, glutamate, ATP, and dopamine D(2) receptor activation, while undifferentiated hES cells only mobilized Ca(2+) from intracellular stores in response to ATP and D(2) receptor-induced activation. Dopamine 31-39 ribosome binding protein 1 Homo sapiens 14-17 20043754-3 2010 We found that hES cell-derived dopamine neurons and neural progenitors raised Ca(2+) from intra- and extracellular compartments in response to depolarization, glutamate, ATP, and dopamine D(2) receptor activation, while undifferentiated hES cells only mobilized Ca(2+) from intracellular stores in response to ATP and D(2) receptor-induced activation. Dopamine 31-39 ribosome binding protein 1 Homo sapiens 237-240 20043754-3 2010 We found that hES cell-derived dopamine neurons and neural progenitors raised Ca(2+) from intra- and extracellular compartments in response to depolarization, glutamate, ATP, and dopamine D(2) receptor activation, while undifferentiated hES cells only mobilized Ca(2+) from intracellular stores in response to ATP and D(2) receptor-induced activation. Glutamic Acid 159-168 ribosome binding protein 1 Homo sapiens 14-17 20043754-3 2010 We found that hES cell-derived dopamine neurons and neural progenitors raised Ca(2+) from intra- and extracellular compartments in response to depolarization, glutamate, ATP, and dopamine D(2) receptor activation, while undifferentiated hES cells only mobilized Ca(2+) from intracellular stores in response to ATP and D(2) receptor-induced activation. Adenosine Triphosphate 170-173 ribosome binding protein 1 Homo sapiens 14-17 20043754-3 2010 We found that hES cell-derived dopamine neurons and neural progenitors raised Ca(2+) from intra- and extracellular compartments in response to depolarization, glutamate, ATP, and dopamine D(2) receptor activation, while undifferentiated hES cells only mobilized Ca(2+) from intracellular stores in response to ATP and D(2) receptor-induced activation. Adenosine Triphosphate 310-313 ribosome binding protein 1 Homo sapiens 14-17 20043754-4 2010 Interestingly, we also found that hES cell-derived dopamine neurons in addition to primary ventral midbrain dopamine neurons were more prone to release Ca(2+) from intracellular stores than non-dopamine neurons following treatment with the neuropeptide neurotensin. Dopamine 51-59 ribosome binding protein 1 Homo sapiens 34-37 20043754-5 2010 Furthermore, hES cell-derived dopamine neurons showed cAMP elevations in response to forskolin and 3-isobutyl-methylxanthine, similar to primary dopamine neurons. Dopamine 30-38 ribosome binding protein 1 Homo sapiens 13-16 20043754-5 2010 Furthermore, hES cell-derived dopamine neurons showed cAMP elevations in response to forskolin and 3-isobutyl-methylxanthine, similar to primary dopamine neurons. Cyclic AMP 54-58 ribosome binding protein 1 Homo sapiens 13-16 20043754-5 2010 Furthermore, hES cell-derived dopamine neurons showed cAMP elevations in response to forskolin and 3-isobutyl-methylxanthine, similar to primary dopamine neurons. Colforsin 85-94 ribosome binding protein 1 Homo sapiens 13-16 20043754-5 2010 Furthermore, hES cell-derived dopamine neurons showed cAMP elevations in response to forskolin and 3-isobutyl-methylxanthine, similar to primary dopamine neurons. 1-Methyl-3-isobutylxanthine 99-124 ribosome binding protein 1 Homo sapiens 13-16 20043754-6 2010 Taken together, these results unravel the temporal sequence by which hES cells acquire Ca(2+) and cAMP signaling competence during dopamine differentiation. Cyclic AMP 98-102 ribosome binding protein 1 Homo sapiens 69-72 20043754-6 2010 Taken together, these results unravel the temporal sequence by which hES cells acquire Ca(2+) and cAMP signaling competence during dopamine differentiation. Dopamine 131-139 ribosome binding protein 1 Homo sapiens 69-72 20512122-1 2010 We report a fully defined synthetic polymer coating, poly[2-(methacryloyloxy)ethyl dimethyl-(3-sulfopropyl)ammonium hydroxide] (PMEDSAH), which sustains long-term human embryonic stem (hES) cell growth in several different culture media, including commercially available defined media. poly(2-(methacryloyloxy)ethyl dimethyl-(3-sulfopropyl)ammonium hydroxide) 53-126 ribosome binding protein 1 Homo sapiens 185-188 19907998-4 2010 Induction of undifferentiated hES cells with RA stimulates expression of epithelial genes such as K18 and p63. Tretinoin 45-47 ribosome binding protein 1 Homo sapiens 30-33 20014103-4 2010 Compared with the conventional slow-freezing method which uses 10% DMSO as a freezing solution and then cultured in the presence of ROCK inhibitor at the first day of culture, we found out that hES cell recovery was significantly enhanced by around 30 % (P < 0.05) by the new freezing solution. Dimethyl Sulfoxide 67-71 ribosome binding protein 1 Homo sapiens 194-197 20408727-2 2009 The authors observed that hES cells attach and grow poorly on Matrigel adsorbed onto polystyrene, while they proliferate when exposed to Matrigel adsorbed onto glass or oxygen plasma treated polystyrene (e.g., "tissue culture" treated polystyrene). Polystyrenes 85-96 ribosome binding protein 1 Homo sapiens 26-29 20408727-2 2009 The authors observed that hES cells attach and grow poorly on Matrigel adsorbed onto polystyrene, while they proliferate when exposed to Matrigel adsorbed onto glass or oxygen plasma treated polystyrene (e.g., "tissue culture" treated polystyrene). Polystyrenes 191-202 ribosome binding protein 1 Homo sapiens 26-29 20408727-2 2009 The authors observed that hES cells attach and grow poorly on Matrigel adsorbed onto polystyrene, while they proliferate when exposed to Matrigel adsorbed onto glass or oxygen plasma treated polystyrene (e.g., "tissue culture" treated polystyrene). Polystyrenes 191-202 ribosome binding protein 1 Homo sapiens 26-29 20408727-3 2009 Furthermore, hES cells grown on the Matrigel-coated tissue culture polystyrene are less likely to differentiate than those grown on the Matrigel-coated glass. Polystyrenes 67-78 ribosome binding protein 1 Homo sapiens 13-16 19448900-3 2009 Here we describe a stirred system with commercial dextran-based microcarriers coated with denatured collagen to scale-up hES cell production. Dextrans 50-57 ribosome binding protein 1 Homo sapiens 121-124 19260014-4 2009 Recently, it has been discovered that an inhibitor of Rho kinase (ROCKi; Y-27632) increases the survival rate of dissociated, single hES cells. Y 27632 73-80 ribosome binding protein 1 Homo sapiens 133-136 18393629-2 2009 Here, we report that ceramide, a bioactive sphingolipid, selectively eliminates hES cells differentially expressing nestin and Tuj1. Ceramides 21-29 ribosome binding protein 1 Homo sapiens 80-83 19056770-6 2009 RESULTS: The use of Y-27632 and Accutase significantly increases the survival of single hES cells after thawing compared with a control group (P < 0.01). Yttrium 20-21 ribosome binding protein 1 Homo sapiens 88-91 19056770-8 2009 Even in the presence of Y-27632, hES cells deficient in cell-cell interaction undergo apoptosis. Y 27632 24-31 ribosome binding protein 1 Homo sapiens 33-36 19252484-3 2009 Here we report that the synergistic action of two inhibitors of SMAD signaling, Noggin and SB431542, is sufficient to induce rapid and complete neural conversion of >80% of hES cells under adherent culture conditions. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 91-99 ribosome binding protein 1 Homo sapiens 176-179 19252484-7 2009 Noggin/SB431542-based neural induction should facilitate the use of hES and hiPS cells in regenerative medicine and disease modeling and obviate the need for protocols based on stromal feeders or embryoid bodies. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 7-15 ribosome binding protein 1 Homo sapiens 68-71 18393629-2 2009 Here, we report that ceramide, a bioactive sphingolipid, selectively eliminates hES cells differentially expressing nestin and Tuj1. Sphingolipids 43-55 ribosome binding protein 1 Homo sapiens 80-83 18393629-4 2009 Ceramide-resistant hES cells express higher levels of the messenger RNA for ceramide-metabolizing enzymes that convert ceramide into pro-mitogenic metabolites. Ceramides 0-8 ribosome binding protein 1 Homo sapiens 19-22 18393629-4 2009 Ceramide-resistant hES cells express higher levels of the messenger RNA for ceramide-metabolizing enzymes that convert ceramide into pro-mitogenic metabolites. Ceramides 76-84 ribosome binding protein 1 Homo sapiens 19-22 18393629-4 2009 Ceramide-resistant hES cells express higher levels of the messenger RNA for ceramide-metabolizing enzymes that convert ceramide into pro-mitogenic metabolites. Ceramides 119-127 ribosome binding protein 1 Homo sapiens 19-22 18393629-5 2009 Based on these findings, we conducted long-term studies to determine whether liposomal ceramide can be used to maintain undifferentiated hES cells free of feeder cells. Ceramides 87-95 ribosome binding protein 1 Homo sapiens 137-140 18393629-6 2009 We continuously cultured hES cells on matrigel for 4 months with liposomal ceramide in a feeder cell-free system. Ceramides 75-83 ribosome binding protein 1 Homo sapiens 25-28 18393629-7 2009 Human ES cells treated with liposomal ceramide maintained their pluripotent state as determined by in vivo and in vitro differentiation studies and contained no chromosomal abnormalities. Ceramides 38-46 ribosome binding protein 1 Homo sapiens 6-8 18393629-8 2009 In conclusion, our findings suggest that exposure to ceramide provides a viable strategy to prevent premature hES cell differentiation and to maintain pluripotent stem cell populations in the absence of feeder cells. Ceramides 53-61 ribosome binding protein 1 Homo sapiens 110-113 18940855-2 2008 Recently, it has been reported that Rho-associated kinase inhibitor Y-27632 markedly reduced dissociation-induced apoptosis of human embryonic stem (hES) cells, and is expected as a novel supplement for hES cell maintenance or differentiation inductions; however, the effects of the chemical are still to be determined in model animals. Y 27632 68-75 ribosome binding protein 1 Homo sapiens 149-152 19077254-5 2008 RESULTS: Our results demonstrate that Lysophosphatidic Acid (LPA) and Sphingosine-1-phosphate (S1P) receptors are functionally expressed in hES-NEP cells and are coupled to multiple cellular signaling pathways. lysophosphatidic acid 38-59 ribosome binding protein 1 Homo sapiens 140-143 19077254-5 2008 RESULTS: Our results demonstrate that Lysophosphatidic Acid (LPA) and Sphingosine-1-phosphate (S1P) receptors are functionally expressed in hES-NEP cells and are coupled to multiple cellular signaling pathways. lysophosphatidic acid 61-64 ribosome binding protein 1 Homo sapiens 140-143 19077254-11 2008 These findings establish human ES cell-derived NEP cells as a model system for studying the role of lysophospholipids in neural progenitors. Lysophospholipids 100-117 ribosome binding protein 1 Homo sapiens 31-33 19006455-2 2008 The aim of this study was to increase the freeze-thaw survival rate of hES cells by utilizing the ROCK inhibitor Y-27632. Y 27632 113-120 ribosome binding protein 1 Homo sapiens 71-74 19006455-3 2008 hES cell colonies were first treated with Y-27632, followed by collagenase IV and TrypLE Select dissociation whereupon small clumps were slow frozen using 90% Knockout serum replacement and 10% dimethyl sulfoxide. Y 27632 42-49 ribosome binding protein 1 Homo sapiens 0-3 19006455-3 2008 hES cell colonies were first treated with Y-27632, followed by collagenase IV and TrypLE Select dissociation whereupon small clumps were slow frozen using 90% Knockout serum replacement and 10% dimethyl sulfoxide. Dimethyl Sulfoxide 194-212 ribosome binding protein 1 Homo sapiens 0-3 19006455-5 2008 Our results show that the use of Y-27632 significantly increases the survival of hES cells after thawing compared with that of the control group. Y 27632 33-40 ribosome binding protein 1 Homo sapiens 81-84 19006455-7 2008 We have concluded that conventional slow freezing with Y-27632 treatment is efficient and convenient for the cryopreservation of hES cells. Y 27632 55-62 ribosome binding protein 1 Homo sapiens 129-132 18940855-2 2008 Recently, it has been reported that Rho-associated kinase inhibitor Y-27632 markedly reduced dissociation-induced apoptosis of human embryonic stem (hES) cells, and is expected as a novel supplement for hES cell maintenance or differentiation inductions; however, the effects of the chemical are still to be determined in model animals. Y 27632 68-75 ribosome binding protein 1 Homo sapiens 203-206 18940855-3 2008 Here, we demonstrated the effect of Y-27632 on cynomolgus monkey ES (cyES) cells. Y 27632 36-43 ribosome binding protein 1 Homo sapiens 65-67 18339212-3 2008 Recently, HES 130/0.4 (6% hydroxyethyl starch, Voluven; Fresenius Kabi, Bad Homburg, Germany) was developed, which demonstrated improved pharmacokinetics and a favourable safety profile in adults compared with hydroxyethyl starch products with a less rapid metabolization. Hydroxyethyl starch 26-45 ribosome binding protein 1 Homo sapiens 10-13 18339212-3 2008 Recently, HES 130/0.4 (6% hydroxyethyl starch, Voluven; Fresenius Kabi, Bad Homburg, Germany) was developed, which demonstrated improved pharmacokinetics and a favourable safety profile in adults compared with hydroxyethyl starch products with a less rapid metabolization. Hydroxyethyl starch 210-229 ribosome binding protein 1 Homo sapiens 10-13 18543426-1 2008 The paper provides the results of a complex experimental and clinical study of the effects of infusion solutions of hydroxyethyl starch (HES 200/0.5--Refortan and HES 130/0.4--Voluven) on hemostatic and systemic hemodynamic parameters in patients operated on for neurosurgical pathology of the brain. Hydroxyethyl starch 116-135 ribosome binding protein 1 Homo sapiens 137-140 18288110-2 2008 Here we show that pancreatic endoderm derived from human embryonic stem (hES) cells efficiently generates glucose-responsive endocrine cells after implantation into mice. Glucose 106-113 ribosome binding protein 1 Homo sapiens 73-76 18288110-5 2008 Finally, in a test of therapeutic potential, we demonstrate that implantation of hES cell-derived pancreatic endoderm protects against streptozotocin-induced hyperglycemia. Streptozocin 135-149 ribosome binding protein 1 Homo sapiens 81-84 18288110-6 2008 Together, these data provide definitive evidence that hES cells are competent to generate glucose-responsive, insulin-secreting cells. Glucose 90-97 ribosome binding protein 1 Homo sapiens 54-57 18447646-3 2008 Using lentivirus (LV)-mediated gene transfer and a tetracycline-controlled trans-repressor (TR), we first established in hES cells a doxycycline (DOX)-inducible expression system of green fluorescent protein (GFP) to probe its reversibility and kinetics. Tetracycline 51-63 ribosome binding protein 1 Homo sapiens 121-124 18447646-3 2008 Using lentivirus (LV)-mediated gene transfer and a tetracycline-controlled trans-repressor (TR), we first established in hES cells a doxycycline (DOX)-inducible expression system of green fluorescent protein (GFP) to probe its reversibility and kinetics. Doxycycline 133-144 ribosome binding protein 1 Homo sapiens 121-124 18447646-3 2008 Using lentivirus (LV)-mediated gene transfer and a tetracycline-controlled trans-repressor (TR), we first established in hES cells a doxycycline (DOX)-inducible expression system of green fluorescent protein (GFP) to probe its reversibility and kinetics. Doxycycline 146-149 ribosome binding protein 1 Homo sapiens 121-124 18447646-4 2008 Upon the addition of DOX, the percentage of GFP(+) hES cells increased time dependently: The time at which 50% of all green cells appeared (T(50)(on)) was 119.5+/-3.2 h; upon DOX removal, GFP expression declined with a half-time (T(50)(off)) of 127.7+/-3.9 h and became completely silenced at day 8. Doxycycline 21-24 ribosome binding protein 1 Homo sapiens 51-54 18447646-4 2008 Upon the addition of DOX, the percentage of GFP(+) hES cells increased time dependently: The time at which 50% of all green cells appeared (T(50)(on)) was 119.5+/-3.2 h; upon DOX removal, GFP expression declined with a half-time (T(50)(off)) of 127.7+/-3.9 h and became completely silenced at day 8. Doxycycline 175-178 ribosome binding protein 1 Homo sapiens 51-54 18447646-7 2008 DOX-induced expression of the Kir2.1 channels in mES and hES cells led to robust expression of the inwardly rectifying potassium (K(+)) current and thereby hyperpolarized the resting membrane potential (RMP). Doxycycline 0-3 ribosome binding protein 1 Homo sapiens 57-60 18447646-7 2008 DOX-induced expression of the Kir2.1 channels in mES and hES cells led to robust expression of the inwardly rectifying potassium (K(+)) current and thereby hyperpolarized the resting membrane potential (RMP). Potassium 119-128 ribosome binding protein 1 Homo sapiens 57-60 17573914-2 2008 Therefore, we have studied the differences in the level of chromatin condensation in pluripotent and all-trans retinoic acid-differentiated hES cells. Tretinoin 111-124 ribosome binding protein 1 Homo sapiens 140-143 17529971-2 2007 Here we show that application of a selective Rho-associated kinase (ROCK) inhibitor, Y-27632, to hES cells markedly diminishes dissociation-induced apoptosis, increases cloning efficiency (from approximately 1% to approximately 27%) and facilitates subcloning after gene transfer. Y 27632 85-92 ribosome binding protein 1 Homo sapiens 97-100 18536648-3 2008 We have optimized current ES cell culture methods by growing mES cells in suspension in a defined medium. 2-(N-morpholino)ethanesulfonic acid 61-64 ribosome binding protein 1 Homo sapiens 26-28 17529971-3 2007 Furthermore, dissociated hES cells treated with Y-27632 are protected from apoptosis even in serum-free suspension (SFEB) culture and form floating aggregates. Y 27632 48-55 ribosome binding protein 1 Homo sapiens 25-28 17529971-4 2007 We demonstrate that the protective ability of Y-27632 enables SFEB-cultured hES cells to survive and differentiate into Bf1(+) cortical and basal telencephalic progenitors, as do SFEB-cultured mouse ES cells. Y 27632 46-53 ribosome binding protein 1 Homo sapiens 76-79 17529971-4 2007 We demonstrate that the protective ability of Y-27632 enables SFEB-cultured hES cells to survive and differentiate into Bf1(+) cortical and basal telencephalic progenitors, as do SFEB-cultured mouse ES cells. Y 27632 46-53 ribosome binding protein 1 Homo sapiens 77-79 17236576-3 2006 Under screening pressure by ampicillin and kanamycin simultaneously, E. coli BL21 (DE3) was cotransformed with pET28a/hES and pGEX-1lambdaT/predhPK-5 and induced with IPTG to express the recombinant proteins. Isopropyl Thiogalactoside 167-171 ribosome binding protein 1 Homo sapiens 118-121 18453264-1 2007 In this chapter, we introduce a co-culture protocol for human embryonic stem (hES) cell differentiation in which dopamine (DA) neurons with midbrain-specific markers are efficiently derived. Dopamine 113-121 ribosome binding protein 1 Homo sapiens 78-81 18453264-1 2007 In this chapter, we introduce a co-culture protocol for human embryonic stem (hES) cell differentiation in which dopamine (DA) neurons with midbrain-specific markers are efficiently derived. Dopamine 123-125 ribosome binding protein 1 Homo sapiens 78-81 15454007-2 2004 METHODS: Lipofectamine-mediated hES gene was transferred into Tca8113 cells, selected with Blasticidin S; The stable transfected cells were inoculated in BALB/c mice, and then the growth of xenografts was observed. Lipofectamine 9-22 ribosome binding protein 1 Homo sapiens 32-35 17266792-4 2006 Surprisingly, our results showed that immediately after post-thaw washing, the overwhelming majority of hES cells were viable (approximately 98%), as assessed by the trypan blue exclusion test. Trypan Blue 166-177 ribosome binding protein 1 Homo sapiens 104-107 17283875-1 2006 OBJECTIVE: To evaluate the effectiveness and safety of hydroxyethyl starch (HES 130/ 0.4, 60 g/L) in resuscitation during shock stage of burns. Hydroxyethyl starch 55-74 ribosome binding protein 1 Homo sapiens 76-79 16828117-6 2006 Accumulation of small particles of iron-oxide (SPIO) in hES was assessed by Prussian blue staining and electron microscopy. ferric oxide 35-45 ribosome binding protein 1 Homo sapiens 56-59 16374523-4 2006 Surprisingly, our results showed that immediately after post-thaw washing, the overwhelming majority of hES cells were viable (approximately 98%), as assessed by the trypan blue exclusion test. Trypan Blue 166-177 ribosome binding protein 1 Homo sapiens 104-107 16374523-7 2006 The vast majority of low temperature-exposed hES colonies gradually underwent cell death upon incubation for a further 90 min at 37 degrees C. Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end-labeling (TUNEL) assay confirmed apoptosis-induced nuclear DNA fragmentation in frozen-thawed hES cells after incubation at 37 degrees C for 90 min. deoxyuridine triphosphate 196-200 ribosome binding protein 1 Homo sapiens 45-48 16374523-7 2006 The vast majority of low temperature-exposed hES colonies gradually underwent cell death upon incubation for a further 90 min at 37 degrees C. Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end-labeling (TUNEL) assay confirmed apoptosis-induced nuclear DNA fragmentation in frozen-thawed hES cells after incubation at 37 degrees C for 90 min. deoxyuridine triphosphate 196-200 ribosome binding protein 1 Homo sapiens 304-307 15920225-1 2005 In Canada, hydroxyethyl starch 264/0.45 (HES 264/0.45; molar weight 264 kDa, molar substitution 0.45) has largely replaced albumin as the colloidal fluid of choice for perioperative intravascular volume expansion. Hydroxyethyl starch 11-30 ribosome binding protein 1 Homo sapiens 41-44 15630682-2 2005 Incorporation of 5-bromo-2-deoxyuridine (BrdU) within newly-synthesized DNA, followed by immunocytochemical staining was used as a means of detecting mitotically-active cells within hES colonies. Bromodeoxyuridine 17-39 ribosome binding protein 1 Homo sapiens 182-185 15519186-6 2004 The use of HES 130/0.4 resulted in marked decrease in RBC aggregation (aggregation index (AI) before and after circulation was 23.5+/-3.8 and 18+/-2.9, respectively), no significant differences being found when compared with Ringer"s lactate group. Lactic Acid 234-241 ribosome binding protein 1 Homo sapiens 11-14 16828117-6 2006 Accumulation of small particles of iron-oxide (SPIO) in hES was assessed by Prussian blue staining and electron microscopy. spio 47-51 ribosome binding protein 1 Homo sapiens 56-59 16828117-6 2006 Accumulation of small particles of iron-oxide (SPIO) in hES was assessed by Prussian blue staining and electron microscopy. ferric ferrocyanide 76-89 ribosome binding protein 1 Homo sapiens 56-59 16828117-13 2006 Prussian blue and electron microscopy have revealed numerous iron particles in the cytoplasm of hES. ferric ferrocyanide 0-13 ribosome binding protein 1 Homo sapiens 96-99 16828117-13 2006 Prussian blue and electron microscopy have revealed numerous iron particles in the cytoplasm of hES. Iron 61-65 ribosome binding protein 1 Homo sapiens 96-99 16451351-4 2006 While basic information for hES can be derived from mES, such information does not correspond on a one-to-one basis. 2-(N-morpholino)ethanesulfonic acid 52-55 ribosome binding protein 1 Homo sapiens 28-31 16898227-5 2006 The resultant hES-derived hepatocytes metabolized the loaded ammonia and lidocaine at 7.8% and 23.6%, respectively. Ammonia 61-68 ribosome binding protein 1 Homo sapiens 14-17 16898227-5 2006 The resultant hES-derived hepatocytes metabolized the loaded ammonia and lidocaine at 7.8% and 23.6%, respectively. Lidocaine 73-82 ribosome binding protein 1 Homo sapiens 14-17 17071251-0 2006 Clinical experience of hydroxyethyl starch (10% HES 200/0.5) in cerebral perfusion pressure protocol for severe head injury. Hydroxyethyl starch 23-42 ribosome binding protein 1 Homo sapiens 48-51 17071251-1 2006 BACKGROUND: The present study was undertaken to evaluate 10% hydroxyethyl starch (HES 200/0.5) with regard to its clinical outcome and safety in the treatment of severe head injury. Hydroxyethyl starch 61-80 ribosome binding protein 1 Homo sapiens 82-85 15715675-2 2005 The purpose of this study was to assess the developmental potential of hES cells to replace the selectively lost midbrain dopamine (DA) neurons in Parkinson"s disease. Dopamine 122-130 ribosome binding protein 1 Homo sapiens 71-74 15715675-2 2005 The purpose of this study was to assess the developmental potential of hES cells to replace the selectively lost midbrain dopamine (DA) neurons in Parkinson"s disease. Dopamine 132-134 ribosome binding protein 1 Homo sapiens 71-74 15715675-6 2005 Furthermore, hES cell-derived DA neurons demonstrated functionality in vitro, releasing DA in response to KCl-induced depolarization and reuptake of DA. Potassium Chloride 106-109 ribosome binding protein 1 Homo sapiens 13-16 15715675-6 2005 Furthermore, hES cell-derived DA neurons demonstrated functionality in vitro, releasing DA in response to KCl-induced depolarization and reuptake of DA. Dopamine 30-32 ribosome binding protein 1 Homo sapiens 13-16 15454007-2 2004 METHODS: Lipofectamine-mediated hES gene was transferred into Tca8113 cells, selected with Blasticidin S; The stable transfected cells were inoculated in BALB/c mice, and then the growth of xenografts was observed. blasticidin S 91-104 ribosome binding protein 1 Homo sapiens 32-35 14684604-3 2004 The levels of human chorionic gonadotropin (hCG), progesterone, and estradiol-17beta in medium from hES cell-derived EBs grown in suspension culture for 1 wk were higher than unconditioned culture medium or medium from undifferentiated hES cells or spontaneously differentiated hES cell colonies. Estradiol 68-84 ribosome binding protein 1 Homo sapiens 100-103 15190785-2 2004 METHODS: To transfect hES gene into Tca8113 cells, lipofectamin was complexed with plasmid encoding hES gene, and blasticidin S antibiotic was adopted to select Tca8113--hES cell clone. lipofectamin 51-63 ribosome binding protein 1 Homo sapiens 22-25 15190785-2 2004 METHODS: To transfect hES gene into Tca8113 cells, lipofectamin was complexed with plasmid encoding hES gene, and blasticidin S antibiotic was adopted to select Tca8113--hES cell clone. lipofectamin 51-63 ribosome binding protein 1 Homo sapiens 100-103 15190785-2 2004 METHODS: To transfect hES gene into Tca8113 cells, lipofectamin was complexed with plasmid encoding hES gene, and blasticidin S antibiotic was adopted to select Tca8113--hES cell clone. lipofectamin 51-63 ribosome binding protein 1 Homo sapiens 100-103 15190785-2 2004 METHODS: To transfect hES gene into Tca8113 cells, lipofectamin was complexed with plasmid encoding hES gene, and blasticidin S antibiotic was adopted to select Tca8113--hES cell clone. blasticidin S 114-125 ribosome binding protein 1 Homo sapiens 22-25 15190785-4 2004 RESULTS: Transfected by hES, the transfergenic Tca8113 cells could grow and proliferate in RPMI--1640 culture medium containing blasticidin S antibiotic. rpmi--1640 91-101 ribosome binding protein 1 Homo sapiens 24-27 15190785-4 2004 RESULTS: Transfected by hES, the transfergenic Tca8113 cells could grow and proliferate in RPMI--1640 culture medium containing blasticidin S antibiotic. blasticidin S 128-141 ribosome binding protein 1 Homo sapiens 24-27 14618246-10 2003 Serum sodium concentrations increased with HYPER-HES and HYPER-DEX to maximal values of 150+/-3 mmol/l and 149+/-4 mmol/l, respectively (baseline 141+/-3 mmol/l, 141+/-1 mmol/l) CONCLUSIONS: Compared to isotonic saline solution, preoperative volume replacement with hyperoncotic colloids improves haemodynamic conditions during the pre-bypass period in patients with normal left ventricular function undergoing coronary artery bypass grafting. Sodium 6-12 ribosome binding protein 1 Homo sapiens 49-52 14998970-9 2004 When in vitro differentiation of hES cells was induced by retinoic acid, three embryonic germ layer cells were identified by RT-PCR or indirect immunocytochemistry. Tretinoin 58-71 ribosome binding protein 1 Homo sapiens 33-36 15319521-4 2004 RESULTS: We found that isoproterenol provokes, similar to the mouse ES cell system, a strong positive chronotropic effect with an EC50 of around 10(-8) M. Moreover, isoproterenol stimulated with a higher EC50 value the slow field potential amplitude, FP(slow), indicating a stimulation of Ca2+ channels in ventricular-like ES cell-derived cardiomyocytes which is shown to be clearly independent from frequency modulation. Isoproterenol 23-36 ribosome binding protein 1 Homo sapiens 1-3 15319521-4 2004 RESULTS: We found that isoproterenol provokes, similar to the mouse ES cell system, a strong positive chronotropic effect with an EC50 of around 10(-8) M. Moreover, isoproterenol stimulated with a higher EC50 value the slow field potential amplitude, FP(slow), indicating a stimulation of Ca2+ channels in ventricular-like ES cell-derived cardiomyocytes which is shown to be clearly independent from frequency modulation. Isoproterenol 23-36 ribosome binding protein 1 Homo sapiens 68-70 15536184-8 2004 When transplanted into 6-hydroxydopamine-treated animals, hES-derived dopaminergic cells integrated into the rat striatum. Oxidopamine 23-40 ribosome binding protein 1 Homo sapiens 58-61 14561891-3 2003 Here we examine the use of biodegradable polymer scaffolds for promoting hES cell growth and differentiation and formation of 3D structures. Polymers 41-48 ribosome binding protein 1 Homo sapiens 73-76 14561891-4 2003 We show that complex structures with features of various committed embryonic tissues can be generated, in vitro, by using early differentiating hES cells and further inducing their differentiation in a supportive 3D environment such as poly(lactic-co-glycolic acid)/poly(L-lactic acid) polymer scaffolds. poly(l-lactic acid) polymer 266-293 ribosome binding protein 1 Homo sapiens 144-147 14561891-5 2003 We found that hES cell differentiation and organization can be influenced by the scaffold and directed by growth factors such as retinoic acid, transforming growth factor beta, activin-A, or insulin-like growth factor. Tretinoin 129-142 ribosome binding protein 1 Homo sapiens 14-17 10548199-9 1999 MEASUREMENTS AND MAIN RESULTS: Standard hemodynamic measurements and echocardiographic data demonstrated that HS-HES and HS induced a higher increase in left ventricular end-diastolic area than HES. Hydrogen 110-112 ribosome binding protein 1 Homo sapiens 113-116 12878617-0 2003 Plasma substitution effects of a new hydroxyethyl starch HES 130/0.4 compared with HES 200/0.5 during and after extended acute normovolaemic haemodilution. Hydroxyethyl starch 37-56 ribosome binding protein 1 Homo sapiens 57-60 10984015-2 2000 We compared the pharmacodynamics and tolerability of ACS with those ofhydroxyethyl starch (HES) in 32 patients (American Society of Anesthesiologists physical status I and II) undergoing elective surgery. Starch 83-89 ribosome binding protein 1 Homo sapiens 91-94 10608543-3 1999 The aim of this study was to compare the effects of posttrauma resuscitation with hydroxyethyl starch (HES) (molecular mass, 250 kDa) or gelatine (molecular mass, 30 kDa), the hypothesis being that HES would reduce capillary leak. Hydroxyethyl Starch Derivatives 82-101 ribosome binding protein 1 Homo sapiens 103-106 10608543-3 1999 The aim of this study was to compare the effects of posttrauma resuscitation with hydroxyethyl starch (HES) (molecular mass, 250 kDa) or gelatine (molecular mass, 30 kDa), the hypothesis being that HES would reduce capillary leak. Hydroxyethyl Starch Derivatives 82-101 ribosome binding protein 1 Homo sapiens 198-201 11810130-0 2001 Decreased circulating levels of von Willebrand factor after intravenous administration of a rapidly degradable hydroxyethyl starch (HES 200/0.5/6) in healthy human subjects. Hydroxyethyl Starch Derivatives 111-130 ribosome binding protein 1 Homo sapiens 132-135 11810130-7 2001 MEASUREMENT AND RESULTS: The infusion of HES resulted in decreased circulating levels of von Willebrand factor antigen (from 85+/-8% to 59+/-6% after HES vs from 80+/-7% to 69+/-8% after albumin, p<0.05) and ristocetin cofactor activity (from 93+/-4 to 67+/-4% after HES vs from 79+/-5 to 75+/-5% after albumin, p<0.01). Ristocetin 211-221 ribosome binding protein 1 Homo sapiens 41-44 10548199-10 1999 In the HS-HES and HS groups, systemic vascular resistances decreased significantly and end-systolic area tended to decrease. Hydrogen 7-9 ribosome binding protein 1 Homo sapiens 10-13 10548199-13 1999 A major increase in cardiac index was observed after hypertonic solutions infusion, from 2.9 +/- 0.3 to 4.1 +/- 0.4 L/min/m2 in the HS-HES group and from 2.7 +/- 0.3 to 3.8 +/- 0.4 L/min/m2 in the HS group. Hydrogen 132-134 ribosome binding protein 1 Homo sapiens 135-138 1623322-5 1992 After processing 13 cycles of 400 ml whole blood/HES-citrate-volume a total yield of 9.20 +/- 2.80 x 10(9) white cells were collected in volumes of 125 ml. Citric Acid 53-60 ribosome binding protein 1 Homo sapiens 49-52 9014063-1 1996 Hydroxyethyl starch 120 (HES 120/0.7, Plasmafusin) is the smallest medium molecular weight HES preparation used as a plasma substitute for all clinical purposes. Hydroxyethyl starch 0-19 ribosome binding protein 1 Homo sapiens 25-28 9014063-1 1996 Hydroxyethyl starch 120 (HES 120/0.7, Plasmafusin) is the smallest medium molecular weight HES preparation used as a plasma substitute for all clinical purposes. Hydroxyethyl starch 0-19 ribosome binding protein 1 Homo sapiens 91-94 9834964-1 1998 The polypeptide, poly-l-tyrosine (PTYR) was incorporated into hydroxyethyl starch (HES) microspheres to modify the surface hydrophobicity in order to allow subsequent radioiodination and assessment of uptake into the intestinal mucosa following oral administration. DL-Tyrosine 17-32 ribosome binding protein 1 Homo sapiens 83-86 9834964-1 1998 The polypeptide, poly-l-tyrosine (PTYR) was incorporated into hydroxyethyl starch (HES) microspheres to modify the surface hydrophobicity in order to allow subsequent radioiodination and assessment of uptake into the intestinal mucosa following oral administration. Phosphotyrosine 34-38 ribosome binding protein 1 Homo sapiens 83-86 9834964-1 1998 The polypeptide, poly-l-tyrosine (PTYR) was incorporated into hydroxyethyl starch (HES) microspheres to modify the surface hydrophobicity in order to allow subsequent radioiodination and assessment of uptake into the intestinal mucosa following oral administration. Hydroxyethyl starch 62-81 ribosome binding protein 1 Homo sapiens 83-86 9834964-7 1998 HES/PTYR was polymerized as films to facilitate contact angle measurement. Phosphotyrosine 4-8 ribosome binding protein 1 Homo sapiens 0-3 9834964-10 1998 The hydrophobicity of the HES microsphere system could be increased by the incorporation of polytyrosine thereby paving the way to radioiodinate the microspheres and perform uptake studies in an animal model. polytyrosine 92-104 ribosome binding protein 1 Homo sapiens 26-29 9553245-2 1998 Aside from gelatin and dextran, modified starch (hydroxyethyl starch, HES) is currently the first-choice means. Starch 41-47 ribosome binding protein 1 Homo sapiens 70-73 1724191-4 1990 With LMWH 4 patients (4.1%) displayed a positive fibrinogen uptake test (1 patient with HES). Heparin, Low-Molecular-Weight 5-9 ribosome binding protein 1 Homo sapiens 88-91 1724191-5 1990 With UFH 5 patients (5%) demonstrated a positive uptake (3 patients with HES). Heparin 5-8 ribosome binding protein 1 Homo sapiens 73-76 34695489-3 2022 METHODS: We differentiated hES-TEPs by mimicking developmental queues with FGF8, Retinoic Acid, Sonic Hedgehog, Noggin and BMP4. Tretinoin 81-94 ribosome binding protein 1 Homo sapiens 27-30 33762722-0 2021 RRBP1 rewires cisplatin resistance in oral squamous cell carcinoma by regulating Hippo pathway. Cisplatin 14-23 ribosome binding protein 1 Homo sapiens 0-5 33762722-4 2021 RESULTS: From the common set of dysregulated genes from both the analysis, RRBP1 was identified to be upregulated in both early and late cisplatin-resistant cells with respect to the sensitive counterpart. Cisplatin 137-146 ribosome binding protein 1 Homo sapiens 75-80 33762722-6 2021 Genetic (knockout) or pharmacological (Radezolid, represses expression of RRBP1) inhibition of RRBP1 restores cisplatin-mediated cell death in chemo-resistant OSCC. Cisplatin 110-119 ribosome binding protein 1 Homo sapiens 74-79 33762722-6 2021 Genetic (knockout) or pharmacological (Radezolid, represses expression of RRBP1) inhibition of RRBP1 restores cisplatin-mediated cell death in chemo-resistant OSCC. Cisplatin 110-119 ribosome binding protein 1 Homo sapiens 95-100 33762722-8 2021 The PDC xenograft data suggests that knockout of RRBP1 induces cisplatin-mediated cell death and facilitates a significant reduction of tumour burden. Cisplatin 63-72 ribosome binding protein 1 Homo sapiens 49-54 33762722-9 2021 CONCLUSION: Overall, our data suggests that (I) RRBP1 is a major driver of cisplatin-resistance in OSCC, (II) RRBP1 regulates YAP1 expression to mediate cisplatin-resistance, (III) Radezolid represses RRBP1 expression and (IV) targeting RRBP1 reverses cisplatin-induced chemoresistance in advanced OSCC. Cisplatin 75-84 ribosome binding protein 1 Homo sapiens 48-53 33762722-9 2021 CONCLUSION: Overall, our data suggests that (I) RRBP1 is a major driver of cisplatin-resistance in OSCC, (II) RRBP1 regulates YAP1 expression to mediate cisplatin-resistance, (III) Radezolid represses RRBP1 expression and (IV) targeting RRBP1 reverses cisplatin-induced chemoresistance in advanced OSCC. Cisplatin 153-162 ribosome binding protein 1 Homo sapiens 110-115 33762722-9 2021 CONCLUSION: Overall, our data suggests that (I) RRBP1 is a major driver of cisplatin-resistance in OSCC, (II) RRBP1 regulates YAP1 expression to mediate cisplatin-resistance, (III) Radezolid represses RRBP1 expression and (IV) targeting RRBP1 reverses cisplatin-induced chemoresistance in advanced OSCC. Cisplatin 153-162 ribosome binding protein 1 Homo sapiens 110-115 33762722-9 2021 CONCLUSION: Overall, our data suggests that (I) RRBP1 is a major driver of cisplatin-resistance in OSCC, (II) RRBP1 regulates YAP1 expression to mediate cisplatin-resistance, (III) Radezolid represses RRBP1 expression and (IV) targeting RRBP1 reverses cisplatin-induced chemoresistance in advanced OSCC. Cisplatin 153-162 ribosome binding protein 1 Homo sapiens 110-115 33762722-9 2021 CONCLUSION: Overall, our data suggests that (I) RRBP1 is a major driver of cisplatin-resistance in OSCC, (II) RRBP1 regulates YAP1 expression to mediate cisplatin-resistance, (III) Radezolid represses RRBP1 expression and (IV) targeting RRBP1 reverses cisplatin-induced chemoresistance in advanced OSCC. radezolid 181-190 ribosome binding protein 1 Homo sapiens 110-115 33762722-9 2021 CONCLUSION: Overall, our data suggests that (I) RRBP1 is a major driver of cisplatin-resistance in OSCC, (II) RRBP1 regulates YAP1 expression to mediate cisplatin-resistance, (III) Radezolid represses RRBP1 expression and (IV) targeting RRBP1 reverses cisplatin-induced chemoresistance in advanced OSCC. radezolid 181-190 ribosome binding protein 1 Homo sapiens 110-115 33762722-9 2021 CONCLUSION: Overall, our data suggests that (I) RRBP1 is a major driver of cisplatin-resistance in OSCC, (II) RRBP1 regulates YAP1 expression to mediate cisplatin-resistance, (III) Radezolid represses RRBP1 expression and (IV) targeting RRBP1 reverses cisplatin-induced chemoresistance in advanced OSCC. radezolid 181-190 ribosome binding protein 1 Homo sapiens 110-115 33762722-9 2021 CONCLUSION: Overall, our data suggests that (I) RRBP1 is a major driver of cisplatin-resistance in OSCC, (II) RRBP1 regulates YAP1 expression to mediate cisplatin-resistance, (III) Radezolid represses RRBP1 expression and (IV) targeting RRBP1 reverses cisplatin-induced chemoresistance in advanced OSCC. Cisplatin 153-162 ribosome binding protein 1 Homo sapiens 110-115 33762722-9 2021 CONCLUSION: Overall, our data suggests that (I) RRBP1 is a major driver of cisplatin-resistance in OSCC, (II) RRBP1 regulates YAP1 expression to mediate cisplatin-resistance, (III) Radezolid represses RRBP1 expression and (IV) targeting RRBP1 reverses cisplatin-induced chemoresistance in advanced OSCC. Cisplatin 153-162 ribosome binding protein 1 Homo sapiens 110-115 33762722-9 2021 CONCLUSION: Overall, our data suggests that (I) RRBP1 is a major driver of cisplatin-resistance in OSCC, (II) RRBP1 regulates YAP1 expression to mediate cisplatin-resistance, (III) Radezolid represses RRBP1 expression and (IV) targeting RRBP1 reverses cisplatin-induced chemoresistance in advanced OSCC. Cisplatin 153-162 ribosome binding protein 1 Homo sapiens 110-115 34695489-3 2022 METHODS: We differentiated hES-TEPs by mimicking developmental queues with FGF8, Retinoic Acid, Sonic Hedgehog, Noggin and BMP4. tetraethylpyrazine 31-35 ribosome binding protein 1 Homo sapiens 27-30 35533849-4 2022 RRP consisted of glucose, galacturonic acid, mannose, rhamnose, galactose, arabinose, xylose, and glucuronic acid (molar ratio: 7.78:7.59:4.23:3.22:3.15:1.65:1.00), with Mw of 327.92 kDa. Glucose 17-24 ribosome binding protein 1 Homo sapiens 0-3 34429755-0 2021 Metformin mitigates PLCepsilon gene expression and modulates the Notch1/Hes and androgen receptor signaling pathways in castration-resistant prostate cancer xenograft models. Metformin 0-9 ribosome binding protein 1 Homo sapiens 72-75 34376038-7 2021 The impact of propranolol on gene expression (Notch and Hes) was evaluated using real-time polymerase chain reaction (RT-PCR, whereas protein levels of Notch1 and Hes1 were measured using Western blotting (WB), simultaneously. Propranolol 14-25 ribosome binding protein 1 Homo sapiens 56-59 35533849-4 2022 RRP consisted of glucose, galacturonic acid, mannose, rhamnose, galactose, arabinose, xylose, and glucuronic acid (molar ratio: 7.78:7.59:4.23:3.22:3.15:1.65:1.00), with Mw of 327.92 kDa. Mannose 45-52 ribosome binding protein 1 Homo sapiens 0-3 35533849-4 2022 RRP consisted of glucose, galacturonic acid, mannose, rhamnose, galactose, arabinose, xylose, and glucuronic acid (molar ratio: 7.78:7.59:4.23:3.22:3.15:1.65:1.00), with Mw of 327.92 kDa. Rhamnose 54-62 ribosome binding protein 1 Homo sapiens 0-3 35533849-4 2022 RRP consisted of glucose, galacturonic acid, mannose, rhamnose, galactose, arabinose, xylose, and glucuronic acid (molar ratio: 7.78:7.59:4.23:3.22:3.15:1.65:1.00), with Mw of 327.92 kDa. Galactose 64-73 ribosome binding protein 1 Homo sapiens 0-3 35533849-4 2022 RRP consisted of glucose, galacturonic acid, mannose, rhamnose, galactose, arabinose, xylose, and glucuronic acid (molar ratio: 7.78:7.59:4.23:3.22:3.15:1.65:1.00), with Mw of 327.92 kDa. Arabinose 75-84 ribosome binding protein 1 Homo sapiens 0-3 35533849-4 2022 RRP consisted of glucose, galacturonic acid, mannose, rhamnose, galactose, arabinose, xylose, and glucuronic acid (molar ratio: 7.78:7.59:4.23:3.22:3.15:1.65:1.00), with Mw of 327.92 kDa. Xylose 86-92 ribosome binding protein 1 Homo sapiens 0-3 35533849-4 2022 RRP consisted of glucose, galacturonic acid, mannose, rhamnose, galactose, arabinose, xylose, and glucuronic acid (molar ratio: 7.78:7.59:4.23:3.22:3.15:1.65:1.00), with Mw of 327.92 kDa. Glucuronic Acid 98-113 ribosome binding protein 1 Homo sapiens 0-3 35533849-6 2022 Furthermore, RRP induced apoptosis by activating the caspase family of proteins and mediating the reactive oxygen species (ROS)-mediated mitochondrial pathway. Reactive Oxygen Species 98-121 ribosome binding protein 1 Homo sapiens 13-16 35533849-6 2022 Furthermore, RRP induced apoptosis by activating the caspase family of proteins and mediating the reactive oxygen species (ROS)-mediated mitochondrial pathway. Reactive Oxygen Species 123-126 ribosome binding protein 1 Homo sapiens 13-16 35577556-9 2022 In the late-luteal phase, the proteins SPTAN1, GOLGB1, TP53BP1, MATR3, RRBP1 and SRRT were upregulated by pioglitazone. Pioglitazone 106-118 ribosome binding protein 1 Homo sapiens 71-76