PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
3691813-5	1987	In UCP this C-terminal stretch represents a structural difference to the similarly folded ADP/ATP carrier which does not form a corresponding cleavage product.	Adenosine Diphosphate	90-93	uncoupling protein 1	Homo sapiens	3-6
3135798-0	1988	A study of GDP binding to purified thermogenin protein from brown adipose tissue.	Guanosine Diphosphate	11-14	uncoupling protein 1	Homo sapiens	35-46
3135798-2	1988	The binding of GDP to purified thermogenin protein was studied by using fluorescence spectroscopy and equilibrium dialysis.	Guanosine Diphosphate	15-18	uncoupling protein 1	Homo sapiens	31-42
3135798-4	1988	GDP binding to thermogenin diminished fluorescence emission in a concentration-dependent manner that exhibited saturation.	Guanosine Diphosphate	0-3	uncoupling protein 1	Homo sapiens	15-26
3135798-14	1988	The data are consistent with the existence of protonated and non-protonated forms of thermogenin protein that both bind GDP.	Guanosine Diphosphate	120-123	uncoupling protein 1	Homo sapiens	85-96
2495940-1	1989	Isolated uncoupling protein (UCP) can be cross-linked, by various disulfide-forming reagents, to dimers.	Disulfides	66-75	uncoupling protein 1	Homo sapiens	29-32
2495940-5	1989	In mitochondria, cross-linking of UCP with disulfide-forming agents is even more efficient than in isolated state.	Disulfides	43-52	uncoupling protein 1	Homo sapiens	34-37
2495940-13	1989	In order to localize the cysteine involved, cross-linked UCP was cleaved by BrCN.	Cysteine	25-33	uncoupling protein 1	Homo sapiens	57-60
2495940-15	1989	Limited trypsinolytic cleavage, previously shown to occur at Lys-292, removed cross-linking in UCP both in the solubilized and mitochondrially bound state.	Lysine	61-64	uncoupling protein 1	Homo sapiens	95-98
2495940-16	1989	The cleaved C-terminal peptide of 11 residues contains only cystein-304 which, thus, should be the only one (out of 7 cysteines in UCP) involved in the S-S bridge formation.	Cysteine	60-67	uncoupling protein 1	Homo sapiens	131-134
2495940-16	1989	The cleaved C-terminal peptide of 11 residues contains only cystein-304 which, thus, should be the only one (out of 7 cysteines in UCP) involved in the S-S bridge formation.	Cysteine	118-127	uncoupling protein 1	Homo sapiens	131-134
3691813-5	1987	In UCP this C-terminal stretch represents a structural difference to the similarly folded ADP/ATP carrier which does not form a corresponding cleavage product.	Adenosine Triphosphate	94-97	uncoupling protein 1	Homo sapiens	3-6
3304899-6	1987	The associations between UCP and both fasting and glucagon-stimulated CP are less pronounced, especially in patients with well-preserved beta-cell function.	Glucagon	50-58	uncoupling protein 1	Homo sapiens	25-28
3322892-4	1987	UCP clearance was higher in NIDDs than in controls.	nidds	28-33	uncoupling protein 1	Homo sapiens	0-3
34047728-4	2021	In this study, we first discovered that ZEA stimulated 3T3-L1 adipocyte browning by increasing the expression of specific markers (Cd137, Tbx1, Sirt1, Cidea, Ucp1, Tmem26, and Cited1), thereby reducing lipid accumulation.	Zeaxanthins	40-43	uncoupling protein 1	Homo sapiens	158-162
3941078-9	1986	The results suggest that ATP modulates the activity of thermogenin, while fatty acids can alter the relationship between ATP and thermogenin activity such that the protein appears to be activated at a higher cellular ATP level in the presence of fatty acids than in their absence.	Fatty Acids	74-85	uncoupling protein 1	Homo sapiens	129-140
3941078-9	1986	The results suggest that ATP modulates the activity of thermogenin, while fatty acids can alter the relationship between ATP and thermogenin activity such that the protein appears to be activated at a higher cellular ATP level in the presence of fatty acids than in their absence.	Adenosine Triphosphate	121-124	uncoupling protein 1	Homo sapiens	129-140
3941078-9	1986	The results suggest that ATP modulates the activity of thermogenin, while fatty acids can alter the relationship between ATP and thermogenin activity such that the protein appears to be activated at a higher cellular ATP level in the presence of fatty acids than in their absence.	Adenosine Triphosphate	121-124	uncoupling protein 1	Homo sapiens	129-140
3941078-9	1986	The results suggest that ATP modulates the activity of thermogenin, while fatty acids can alter the relationship between ATP and thermogenin activity such that the protein appears to be activated at a higher cellular ATP level in the presence of fatty acids than in their absence.	Fatty Acids	246-257	uncoupling protein 1	Homo sapiens	55-66
3941078-9	1986	The results suggest that ATP modulates the activity of thermogenin, while fatty acids can alter the relationship between ATP and thermogenin activity such that the protein appears to be activated at a higher cellular ATP level in the presence of fatty acids than in their absence.	Fatty Acids	246-257	uncoupling protein 1	Homo sapiens	129-140
6089979-8	1984	At the mitochondrial level, fatty acids appear to interact with an "uncoupling" protein (thermogenin or 32 000 relative mass protein) localized in the inner membrane that confers upon brown adipose mitochondria a unique sensitivity for fatty acid uncoupling.	Fatty Acids	28-39	uncoupling protein 1	Homo sapiens	89-100
6089979-8	1984	At the mitochondrial level, fatty acids appear to interact with an "uncoupling" protein (thermogenin or 32 000 relative mass protein) localized in the inner membrane that confers upon brown adipose mitochondria a unique sensitivity for fatty acid uncoupling.	Fatty Acids	28-38	uncoupling protein 1	Homo sapiens	89-100
3941078-1	1986	Presumptive evidence suggests that the brown fat mitochondrial uncoupling protein, thermogenin, is involved in the mechanism of stimulation of respiration by norepinephrine in the intact tissue.	Norepinephrine	158-172	uncoupling protein 1	Homo sapiens	83-94
3941078-8	1986	Their effect on thermogenin was monitored as the capacity of the cells for reverse electron transport from durohydroquinone.	duroquinol	107-123	uncoupling protein 1	Homo sapiens	16-27
3941078-9	1986	The results suggest that ATP modulates the activity of thermogenin, while fatty acids can alter the relationship between ATP and thermogenin activity such that the protein appears to be activated at a higher cellular ATP level in the presence of fatty acids than in their absence.	Adenosine Triphosphate	25-28	uncoupling protein 1	Homo sapiens	55-66
2868887-1	1985	The isolated uncoupling protein (UCP) from brown fat adipose tissue mitochondria has been reconstituted into artificial phospholipid vesicles.	Phospholipids	120-132	uncoupling protein 1	Homo sapiens	13-31
2868887-1	1985	The isolated uncoupling protein (UCP) from brown fat adipose tissue mitochondria has been reconstituted into artificial phospholipid vesicles.	Phospholipids	120-132	uncoupling protein 1	Homo sapiens	33-36
2868887-4	1985	H+ influx is inhibited to more than 90% by GTP addition, in the assay for UCP activity.	Guanosine Triphosphate	43-46	uncoupling protein 1	Homo sapiens	74-77
2868887-7	1985	Binding studies with GTP show that most of the active UCP are oriented with the binding site outside as in mitochondria, and that in GTP-loaded vesicles GTP is also bound at the outside.	Guanosine Triphosphate	21-24	uncoupling protein 1	Homo sapiens	54-57
2868887-7	1985	Binding studies with GTP show that most of the active UCP are oriented with the binding site outside as in mitochondria, and that in GTP-loaded vesicles GTP is also bound at the outside.	Guanosine Triphosphate	133-136	uncoupling protein 1	Homo sapiens	54-57
2868887-7	1985	Binding studies with GTP show that most of the active UCP are oriented with the binding site outside as in mitochondria, and that in GTP-loaded vesicles GTP is also bound at the outside.	Guanosine Triphosphate	133-136	uncoupling protein 1	Homo sapiens	54-57
6819159-1	1982	Thermogenin is the purine-nucleotide binding polypeptide in brown adipose tissue mitochondria (Mr 32 000) which confers upon these mitochondria the ability to produce heat.	purine	19-25	uncoupling protein 1	Homo sapiens	0-11
33750832-2	2021	We show that, in comparison to the 11 artiodactyl brains studied (from 11 species), the 5 cetacean brains (from 3 species), exhibit an expanded expression of uncoupling protein 1 (UCP1, UCPs being mitochondrial inner membrane proteins that dissipate the proton gradient to generate heat) in cortical neurons, immunolocalization of UCP4 within a substantial proportion of glia throughout the brain, and an increased density of noradrenergic axonal boutons (noradrenaline functioning to control concentrations of and activate UCPs).	Norepinephrine	456-469	uncoupling protein 1	Homo sapiens	158-178
33826782-0	2021	Fibroblast growth factor induced Ucp1 expression in preadipocytes requires PGE2 biosynthesis and glycolytic flux.	Dinoprostone	75-79	uncoupling protein 1	Homo sapiens	33-37
33826782-5	2021	Oxylipin measurement by LC-MS/MS in FGF8b conditioned media identified prostaglandin E2 as a putative mediator of FGF8b induced Ucp1 transcription.	Dinoprostone	71-87	uncoupling protein 1	Homo sapiens	128-132
33826782-6	2021	RNA interference and pharmacological inhibition of the prostaglandin E2 biosynthetic pathway confirmed that PGE2 is causally involved in the control over Ucp1 transcription.	Dinoprostone	55-71	uncoupling protein 1	Homo sapiens	154-158
33826782-6	2021	RNA interference and pharmacological inhibition of the prostaglandin E2 biosynthetic pathway confirmed that PGE2 is causally involved in the control over Ucp1 transcription.	Dinoprostone	108-112	uncoupling protein 1	Homo sapiens	154-158
33826782-9	2021	Thus, we conclude that paracrine FGFs co-regulate prostaglandin and glucose metabolism to induce Ucp1 expression in a Nrf1/Hes1-dependent manner in preadipocytes, revealing a novel regulatory network in control of Ucp1 expression in a formerly unrecognized cell type.	Prostaglandins	50-63	uncoupling protein 1	Homo sapiens	97-101
33826782-9	2021	Thus, we conclude that paracrine FGFs co-regulate prostaglandin and glucose metabolism to induce Ucp1 expression in a Nrf1/Hes1-dependent manner in preadipocytes, revealing a novel regulatory network in control of Ucp1 expression in a formerly unrecognized cell type.	Glucose	68-75	uncoupling protein 1	Homo sapiens	97-101
33841324-3	2021	In contrast to white adipocytes that store energy as triglycerides in unilocular lipid droplet, brown and brown-like or beige adipocytes utilize fatty acids (FAs) and glucose at a high rate mainly by uncoupling protein 1 (UCP1) action to uncouple mitochondrial proton gradient from ATP synthesis, dissipating energy as heat.	Fatty Acids	145-156	uncoupling protein 1	Homo sapiens	200-220
33841324-3	2021	In contrast to white adipocytes that store energy as triglycerides in unilocular lipid droplet, brown and brown-like or beige adipocytes utilize fatty acids (FAs) and glucose at a high rate mainly by uncoupling protein 1 (UCP1) action to uncouple mitochondrial proton gradient from ATP synthesis, dissipating energy as heat.	Fatty Acids	158-161	uncoupling protein 1	Homo sapiens	200-220
33841324-3	2021	In contrast to white adipocytes that store energy as triglycerides in unilocular lipid droplet, brown and brown-like or beige adipocytes utilize fatty acids (FAs) and glucose at a high rate mainly by uncoupling protein 1 (UCP1) action to uncouple mitochondrial proton gradient from ATP synthesis, dissipating energy as heat.	Glucose	167-174	uncoupling protein 1	Homo sapiens	200-220
33841324-3	2021	In contrast to white adipocytes that store energy as triglycerides in unilocular lipid droplet, brown and brown-like or beige adipocytes utilize fatty acids (FAs) and glucose at a high rate mainly by uncoupling protein 1 (UCP1) action to uncouple mitochondrial proton gradient from ATP synthesis, dissipating energy as heat.	Glucose	167-174	uncoupling protein 1	Homo sapiens	222-226
33841324-3	2021	In contrast to white adipocytes that store energy as triglycerides in unilocular lipid droplet, brown and brown-like or beige adipocytes utilize fatty acids (FAs) and glucose at a high rate mainly by uncoupling protein 1 (UCP1) action to uncouple mitochondrial proton gradient from ATP synthesis, dissipating energy as heat.	Adenosine Triphosphate	282-285	uncoupling protein 1	Homo sapiens	222-226
33887198-3	2021	A low isoleucine diet reprograms liver and adipose metabolism, increasing hepatic insulin sensitivity and ketogenesis and increasing energy expenditure, activating the FGF21-UCP1 axis.	Isoleucine	6-16	uncoupling protein 1	Homo sapiens	174-178
33556486-7	2021	When ER stress was reduced by the chemical chaperone tauroursodeoxycholic acid (TUDCA), the expression of the beige adipocytes marker uncoupling protein 1 (UCP1) was significantly enhanced in inguinal white adipose tissue (iWAT) and high fat diet (HFD)-induced abnormal metabolic phenotype was improved.	ursodoxicoltaurine	53-78	uncoupling protein 1	Homo sapiens	134-154
33556486-7	2021	When ER stress was reduced by the chemical chaperone tauroursodeoxycholic acid (TUDCA), the expression of the beige adipocytes marker uncoupling protein 1 (UCP1) was significantly enhanced in inguinal white adipose tissue (iWAT) and high fat diet (HFD)-induced abnormal metabolic phenotype was improved.	ursodoxicoltaurine	53-78	uncoupling protein 1	Homo sapiens	156-160
33556486-7	2021	When ER stress was reduced by the chemical chaperone tauroursodeoxycholic acid (TUDCA), the expression of the beige adipocytes marker uncoupling protein 1 (UCP1) was significantly enhanced in inguinal white adipose tissue (iWAT) and high fat diet (HFD)-induced abnormal metabolic phenotype was improved.	ursodoxicoltaurine	80-85	uncoupling protein 1	Homo sapiens	134-154
33556486-7	2021	When ER stress was reduced by the chemical chaperone tauroursodeoxycholic acid (TUDCA), the expression of the beige adipocytes marker uncoupling protein 1 (UCP1) was significantly enhanced in inguinal white adipose tissue (iWAT) and high fat diet (HFD)-induced abnormal metabolic phenotype was improved.	ursodoxicoltaurine	80-85	uncoupling protein 1	Homo sapiens	156-160
33252166-2	2021	Its ability to convert chemical energy in glucose and free fatty acids to heat is conferred by a unique protein, UCP-1.	Glucose	42-49	uncoupling protein 1	Homo sapiens	113-118
33252166-2	2021	Its ability to convert chemical energy in glucose and free fatty acids to heat is conferred by a unique protein, UCP-1.	Fatty Acids	59-70	uncoupling protein 1	Homo sapiens	113-118
33071240-5	2021	Ca2+-induced mitochondrial reactive oxygen species activate Ucp1.	Reactive Oxygen Species	27-50	uncoupling protein 1	Homo sapiens	60-64
33750832-2	2021	We show that, in comparison to the 11 artiodactyl brains studied (from 11 species), the 5 cetacean brains (from 3 species), exhibit an expanded expression of uncoupling protein 1 (UCP1, UCPs being mitochondrial inner membrane proteins that dissipate the proton gradient to generate heat) in cortical neurons, immunolocalization of UCP4 within a substantial proportion of glia throughout the brain, and an increased density of noradrenergic axonal boutons (noradrenaline functioning to control concentrations of and activate UCPs).	Norepinephrine	456-469	uncoupling protein 1	Homo sapiens	180-184
33479386-7	2021	In the browning experiment, pioglitazone, the PPAR-gamma agonist, increased UCP1 mRNA when compared to vehicle (p < 0.01).	Pioglitazone	28-40	uncoupling protein 1	Homo sapiens	76-80
33634052-1	2020	Brown adipose tissue (BAT) is a thermogenic organ owing to its unique expression of uncoupling protein 1 (UCP1), which is a proton channel in the inner mitochondrial membrane used to dissipate the proton gradient and uncouple the electron transport chain to generate heat instead of adenosine triphosphate.	Adenosine	283-292	uncoupling protein 1	Homo sapiens	84-104
33634052-1	2020	Brown adipose tissue (BAT) is a thermogenic organ owing to its unique expression of uncoupling protein 1 (UCP1), which is a proton channel in the inner mitochondrial membrane used to dissipate the proton gradient and uncouple the electron transport chain to generate heat instead of adenosine triphosphate.	Adenosine	283-292	uncoupling protein 1	Homo sapiens	106-110
33634052-5	2020	Here, we summarize the regulatory mechanisms underlying UCP1 expression, report the number of poly(A) signals identified or predicted in Ucp1 genes across species, and discuss the potential and caution in targeting UCP1 for enhancing thermogenesis and metabolic fitness.	Poly A	94-101	uncoupling protein 1	Homo sapiens	137-141
33479386-8	2021	Interestingly, 10, 100, and 1000 ng/ml CQ extract treatment on hWA significantly enhanced UCP1 expression in a dose-dependent manner when compared to pioglitazone treatment (p < 0.001 all).	Chloroquine	39-41	uncoupling protein 1	Homo sapiens	90-94
33479386-9	2021	In conclusion, CQ decreased waist and hip circumferences in obese humans and enhanced UCP1 mRNA in hWA suggestive of its action via browning of hWA.	Chloroquine	15-17	uncoupling protein 1	Homo sapiens	86-90
32368968-6	2021	The adaptive induction of white adipose tissues (WAT) to beige adipose tissues (beAT) showed the beneficial effects on glucose oxidation, ROS protection, and mitochondrial function preservation through the uncoupling protein 1 (UCP1)-independent thermogenesis of beAT.	Glucose	119-126	uncoupling protein 1	Homo sapiens	228-232
32368968-6	2021	The adaptive induction of white adipose tissues (WAT) to beige adipose tissues (beAT) showed the beneficial effects on glucose oxidation, ROS protection, and mitochondrial function preservation through the uncoupling protein 1 (UCP1)-independent thermogenesis of beAT.	ros	138-141	uncoupling protein 1	Homo sapiens	228-232
32859378-1	2020	Beige/brite adipocytes, which express high levels of uncoupling protein 1 (UCP1) to generate heat using stored triglycerides, are induced under specific stimuli such as cold exposure in inguinal white adipose tissue (iWAT).	Triglycerides	111-124	uncoupling protein 1	Homo sapiens	53-73
33246168-3	2021	Farnesol induced the expression of thermogenic factors such as uncoupling protein 1 (UCP1), peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1alpha), and PR domain zinc-finger protein 16 (PRDM16) together with the phosphorylation of AMP-activated protein kinase alpha (AMPKalpha) in brown adipose tissue and primary cultured brown adipocytes.	Farnesol	0-8	uncoupling protein 1	Homo sapiens	63-83
33246168-3	2021	Farnesol induced the expression of thermogenic factors such as uncoupling protein 1 (UCP1), peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1alpha), and PR domain zinc-finger protein 16 (PRDM16) together with the phosphorylation of AMP-activated protein kinase alpha (AMPKalpha) in brown adipose tissue and primary cultured brown adipocytes.	Farnesol	0-8	uncoupling protein 1	Homo sapiens	85-89
33055467-3	2020	The aim of this study was to identify the presence of UCP-1 in the sebaceous glands on the skin of the Sunda porcupine.	sunda porcupine	103-118	uncoupling protein 1	Homo sapiens	54-59
32859378-1	2020	Beige/brite adipocytes, which express high levels of uncoupling protein 1 (UCP1) to generate heat using stored triglycerides, are induced under specific stimuli such as cold exposure in inguinal white adipose tissue (iWAT).	Triglycerides	111-124	uncoupling protein 1	Homo sapiens	75-79
32569352-5	2020	Functionally, they respond to a plethora of stimuli to engage uncoupling protein 1 (UCP1)-dependent and independent thermogenic programs, thus improving systemic glucose homeostasis, lipid metabolism, and the clearance of branched-chain amino acids.	Amino Acids, Branched-Chain	222-248	uncoupling protein 1	Homo sapiens	84-88
32954822-0	2020	Role of creatine and creatine kinase in UCP1-independent adipocyte thermogenesis.	Creatine	8-16	uncoupling protein 1	Homo sapiens	40-44
32882342-0	2020	Decreased UCP-1 expression in beige adipocytes from adipose-derived stem cells of type 2 diabetes patients associates with mitochondrial ROS accumulation during obesity.	ros	137-140	uncoupling protein 1	Homo sapiens	10-15
32882342-11	2020	CONCLUSIONS: In summary, compromised UCP1 expression in beige adipocytes of T2DM patients may cause increase of mitochondrial ROS.	ros	126-129	uncoupling protein 1	Homo sapiens	37-41
33193083-10	2020	The autophagy inhibitor 3-methyladenine restored the reduced UCP1 protein level and thermogenic capacity caused by inhibiting FOXC2-AS1.	3-methyladenine	24-39	uncoupling protein 1	Homo sapiens	61-65
32569352-5	2020	Functionally, they respond to a plethora of stimuli to engage uncoupling protein 1 (UCP1)-dependent and independent thermogenic programs, thus improving systemic glucose homeostasis, lipid metabolism, and the clearance of branched-chain amino acids.	Amino Acids, Branched-Chain	222-248	uncoupling protein 1	Homo sapiens	62-82
33110450-5	2020	Results: Peroxisome proliferator activated receptor gamma- coactivator-1 alpha (PGC-1 alpha) and uncoupling protein 1 gene expression increased significantly in the normal weight group, but not in the overweight group, with norepinephrine treatment.	Norepinephrine	224-238	uncoupling protein 1	Homo sapiens	97-117
32088243-10	2020	Moreover, we demonstrate that SB interacted with rs3811791 of UCP1 was associated with T2DM, and PA interacted with rs3811791 of UCP1 was associated with the level of HOMA-IR, HDL-C, and TG.	Antimony	30-32	uncoupling protein 1	Homo sapiens	62-66
33071960-6	2020	Accumulating evidence links retinoid action to brown fat function and browning of WAT mainly via orchestrating a transcriptional BAT program in adipocytes including expression of key thermogenic genes such as uncoupling protein 1.	Retinoids	28-36	uncoupling protein 1	Homo sapiens	209-229
32927882-8	2020	cAMP treatment led to the downregulation of mitophagy through PKA in both types of adipocytes, resulting in more fragmented mitochondria and increased UCP1 levels.	Cyclic AMP	0-4	uncoupling protein 1	Homo sapiens	151-155
32439414-1	2020	Cold exposure activates brown and brown-like adipocytes that dissipate large amounts of glucose and fatty acids via uncoupling protein 1 (UCP1) to drive non-shivering thermogenesis (NST).	Glucose	88-95	uncoupling protein 1	Homo sapiens	116-136
32439414-1	2020	Cold exposure activates brown and brown-like adipocytes that dissipate large amounts of glucose and fatty acids via uncoupling protein 1 (UCP1) to drive non-shivering thermogenesis (NST).	Glucose	88-95	uncoupling protein 1	Homo sapiens	138-142
32439414-1	2020	Cold exposure activates brown and brown-like adipocytes that dissipate large amounts of glucose and fatty acids via uncoupling protein 1 (UCP1) to drive non-shivering thermogenesis (NST).	Fatty Acids	100-111	uncoupling protein 1	Homo sapiens	116-136
32439414-1	2020	Cold exposure activates brown and brown-like adipocytes that dissipate large amounts of glucose and fatty acids via uncoupling protein 1 (UCP1) to drive non-shivering thermogenesis (NST).	Fatty Acids	100-111	uncoupling protein 1	Homo sapiens	138-142
32647572-17	2020	Disrupting FABP7-mediated fatty acid metabolism can unlock UCP1-mediated thermogenesis, potentially making it possible to develop therapies to target thermogenesis.	Fatty Acids	26-36	uncoupling protein 1	Homo sapiens	59-63
32605639-10	2020	Pronounced activation of lipogenic gene expression in the liver and down-regulated expression of uncoupling protein-1 (UCP1) and peroxisome-proliferator-activated receptor-gamma co-activator-1alpha (PGC-1alpha) in brown adipose tissue (BAT) was observed in the olanzapine-only group.	Olanzapine	261-271	uncoupling protein 1	Homo sapiens	97-117
32248079-4	2020	RESULTS: All dual PPARalpha/gamma activators tested robustly increased uncoupling protein 1 (Ucp1) expression in both mouse and human adipocytes in vitro, with tesaglitazar leading to the largest Ucp1 induction.	tesaglitazar	160-172	uncoupling protein 1	Homo sapiens	196-200
32217148-0	2020	Oleoylethanolamide supplementation in obese patients newly diagnosed with non-alcoholic fatty liver disease: effects on metabolic parameters, anthropometric indices, and expression of PPAR-alpha, UCP1, and UCP2 genes.	oleoylethanolamide	0-18	uncoupling protein 1	Homo sapiens	196-200
32217148-2	2020	The objective of the present study was to examine the effects of OEA supplementation along with weight loss intervention on the expression of PPAR-alpha, uncoupling proteins 1and 2 (UCP1 and UCP2) genes in the peripheral blood mononuclear cells (PBMCs), metabolic parameters, and anthropometric indices among obese patients with NAFLD.	oleoylethanolamide	65-68	uncoupling protein 1	Homo sapiens	182-186
32088243-10	2020	Moreover, we demonstrate that SB interacted with rs3811791 of UCP1 was associated with T2DM, and PA interacted with rs3811791 of UCP1 was associated with the level of HOMA-IR, HDL-C, and TG.	Protactinium	97-99	uncoupling protein 1	Homo sapiens	129-133
32273338-6	2020	Consistently, the Gyk KD inhibited Ucp1 expression induced by treatment with the beta-adrenergic receptors (betaAR) agonist isoproterenol (Iso) in vitro and resulted in impaired uncoupled respiration.	Isoproterenol	124-137	uncoupling protein 1	Homo sapiens	35-39
32358195-6	2020	Selenium was selectively incorporated into regulatory sites on key metabolic proteins, including as selenocysteine-replacing cysteine at position 253 in uncoupling protein 1 (UCP1).	Selenium	0-8	uncoupling protein 1	Homo sapiens	153-173
32358195-6	2020	Selenium was selectively incorporated into regulatory sites on key metabolic proteins, including as selenocysteine-replacing cysteine at position 253 in uncoupling protein 1 (UCP1).	Selenium	0-8	uncoupling protein 1	Homo sapiens	175-179
32358195-6	2020	Selenium was selectively incorporated into regulatory sites on key metabolic proteins, including as selenocysteine-replacing cysteine at position 253 in uncoupling protein 1 (UCP1).	Selenocysteine	100-114	uncoupling protein 1	Homo sapiens	153-173
32358195-6	2020	Selenium was selectively incorporated into regulatory sites on key metabolic proteins, including as selenocysteine-replacing cysteine at position 253 in uncoupling protein 1 (UCP1).	Selenocysteine	100-114	uncoupling protein 1	Homo sapiens	175-179
32358195-6	2020	Selenium was selectively incorporated into regulatory sites on key metabolic proteins, including as selenocysteine-replacing cysteine at position 253 in uncoupling protein 1 (UCP1).	Cysteine	106-114	uncoupling protein 1	Homo sapiens	153-173
32358195-6	2020	Selenium was selectively incorporated into regulatory sites on key metabolic proteins, including as selenocysteine-replacing cysteine at position 253 in uncoupling protein 1 (UCP1).	Cysteine	106-114	uncoupling protein 1	Homo sapiens	175-179
32358195-8	2020	Remarkably, dietary selenium supplementation elevated facultative incorporation into UCP1, elevated energy expenditure through thermogenic adipose tissue, and protected against obesity.	Selenium	20-28	uncoupling protein 1	Homo sapiens	85-89
32273338-6	2020	Consistently, the Gyk KD inhibited Ucp1 expression induced by treatment with the beta-adrenergic receptors (betaAR) agonist isoproterenol (Iso) in vitro and resulted in impaired uncoupled respiration.	Isoproterenol	139-142	uncoupling protein 1	Homo sapiens	35-39
32273338-12	2020	Our findings suggest that Gyk stimulates Ucp1 expression via a mechanism that partially depends on the betaAR-cAMP-CREB pathway and on Gyk-mediated regulation of fatty acid metabolism.	Cyclic AMP	110-114	uncoupling protein 1	Homo sapiens	41-45
32273338-12	2020	Our findings suggest that Gyk stimulates Ucp1 expression via a mechanism that partially depends on the betaAR-cAMP-CREB pathway and on Gyk-mediated regulation of fatty acid metabolism.	Fatty Acids	162-172	uncoupling protein 1	Homo sapiens	41-45
32170654-1	2020	The main function of brown adipose tissue (BAT) is thermogenesis, a process mediated by uncoupling protein 1 (UCP1), which is located in the inner mitochondrial membrane and acts uncoupling oxidative phosphorylation from ATP production, thereby dissipating energy as heat.	Adenosine Triphosphate	221-224	uncoupling protein 1	Homo sapiens	88-108
32170654-1	2020	The main function of brown adipose tissue (BAT) is thermogenesis, a process mediated by uncoupling protein 1 (UCP1), which is located in the inner mitochondrial membrane and acts uncoupling oxidative phosphorylation from ATP production, thereby dissipating energy as heat.	Adenosine Triphosphate	221-224	uncoupling protein 1	Homo sapiens	110-114
32170654-8	2020	In addition, resveratrol seems to promote browning by activating peroxisome proliferator-activated receptor (PPAR), while the lack of changes in mitochondrial biogenesis suggests that probably the browning process occurs by direct resveratrol-mediated upregulation of ucp1 mRNA expression.	Resveratrol	231-242	uncoupling protein 1	Homo sapiens	268-272
31401979-5	2020	SA treatment of brown adipocytes induced the expression of brown-adipocyte activation-related genes such as Ucp1, Pgc-1alpha, and Prdm16.	sinapinic acid	0-2	uncoupling protein 1	Homo sapiens	108-112
32351999-6	2020	Sinapic acid increased the expression of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and UCP1.	sinapinic acid	0-12	uncoupling protein 1	Homo sapiens	126-130
31867674-7	2020	In TERT-hBA, UCP1 mRNA expression was stimulated 11.0-fold by dibutyryl cAMP (dbcAMP), 8.0-fold to 8.4-fold by isoproterenol (ISO; a pan-ADRB agonist), and 6.1-fold to 12.7-fold by dobutamine (ADRB1 agonist), whereas neither procaterol (ADRB2 agonist), CL314.432, or Mirabegron (ADRB3 agonists) affected UCP1.	Bucladesine	62-76	uncoupling protein 1	Homo sapiens	13-17
31867674-7	2020	In TERT-hBA, UCP1 mRNA expression was stimulated 11.0-fold by dibutyryl cAMP (dbcAMP), 8.0-fold to 8.4-fold by isoproterenol (ISO; a pan-ADRB agonist), and 6.1-fold to 12.7-fold by dobutamine (ADRB1 agonist), whereas neither procaterol (ADRB2 agonist), CL314.432, or Mirabegron (ADRB3 agonists) affected UCP1.	Isoproterenol	111-124	uncoupling protein 1	Homo sapiens	13-17
31867674-7	2020	In TERT-hBA, UCP1 mRNA expression was stimulated 11.0-fold by dibutyryl cAMP (dbcAMP), 8.0-fold to 8.4-fold by isoproterenol (ISO; a pan-ADRB agonist), and 6.1-fold to 12.7-fold by dobutamine (ADRB1 agonist), whereas neither procaterol (ADRB2 agonist), CL314.432, or Mirabegron (ADRB3 agonists) affected UCP1.	Isoproterenol	126-129	uncoupling protein 1	Homo sapiens	13-17
31867674-7	2020	In TERT-hBA, UCP1 mRNA expression was stimulated 11.0-fold by dibutyryl cAMP (dbcAMP), 8.0-fold to 8.4-fold by isoproterenol (ISO; a pan-ADRB agonist), and 6.1-fold to 12.7-fold by dobutamine (ADRB1 agonist), whereas neither procaterol (ADRB2 agonist), CL314.432, or Mirabegron (ADRB3 agonists) affected UCP1.	Dobutamine	181-191	uncoupling protein 1	Homo sapiens	13-17
31867674-7	2020	In TERT-hBA, UCP1 mRNA expression was stimulated 11.0-fold by dibutyryl cAMP (dbcAMP), 8.0-fold to 8.4-fold by isoproterenol (ISO; a pan-ADRB agonist), and 6.1-fold to 12.7-fold by dobutamine (ADRB1 agonist), whereas neither procaterol (ADRB2 agonist), CL314.432, or Mirabegron (ADRB3 agonists) affected UCP1.	Procaterol	225-235	uncoupling protein 1	Homo sapiens	13-17
31867674-7	2020	In TERT-hBA, UCP1 mRNA expression was stimulated 11.0-fold by dibutyryl cAMP (dbcAMP), 8.0-fold to 8.4-fold by isoproterenol (ISO; a pan-ADRB agonist), and 6.1-fold to 12.7-fold by dobutamine (ADRB1 agonist), whereas neither procaterol (ADRB2 agonist), CL314.432, or Mirabegron (ADRB3 agonists) affected UCP1.	cl314	253-258	uncoupling protein 1	Homo sapiens	13-17
32344721-9	2020	Additionally, THs can exert Ucp1-independent effects on thermogenesis, most likely through activation of exothermic metabolic pathways.	Thorium	14-17	uncoupling protein 1	Homo sapiens	28-32
31867674-9	2020	Selective knockdown of ADRB1 significantly attenuated ISO-induced UCP1 expression.	Isoproterenol	54-57	uncoupling protein 1	Homo sapiens	66-70
32149342-6	2020	Furthermore, there is a large overlap in their signaling pathways, as signaling events that raise cAMP or cGMP generally increase adipocyte lipolysis and cause changes that are commonly referred to as browning: increasing mitochondrial biogenesis, uncoupling protein 1 (UCP1) expression and respiration.	Cyclic GMP	106-110	uncoupling protein 1	Homo sapiens	270-274
32210919-3	2020	The canonical pathway of UCP1 activation includes lipolytic release of free fatty acids in response to an adrenergic signal.	Fatty Acids, Nonesterified	71-87	uncoupling protein 1	Homo sapiens	25-29
32210919-4	2020	Activating fatty acids overcome constitutive inhibition of UCP1 by the di- and triphosphate forms of purine nucleotides, i.e., ATP, ADP, GTP, and GDP.	Fatty Acids	11-22	uncoupling protein 1	Homo sapiens	59-63
32210919-4	2020	Activating fatty acids overcome constitutive inhibition of UCP1 by the di- and triphosphate forms of purine nucleotides, i.e., ATP, ADP, GTP, and GDP.	di- and triphosphate	71-91	uncoupling protein 1	Homo sapiens	59-63
32210919-4	2020	Activating fatty acids overcome constitutive inhibition of UCP1 by the di- and triphosphate forms of purine nucleotides, i.e., ATP, ADP, GTP, and GDP.	Purine Nucleotides	101-119	uncoupling protein 1	Homo sapiens	59-63
32210919-4	2020	Activating fatty acids overcome constitutive inhibition of UCP1 by the di- and triphosphate forms of purine nucleotides, i.e., ATP, ADP, GTP, and GDP.	Adenosine Triphosphate	127-130	uncoupling protein 1	Homo sapiens	59-63
32210919-4	2020	Activating fatty acids overcome constitutive inhibition of UCP1 by the di- and triphosphate forms of purine nucleotides, i.e., ATP, ADP, GTP, and GDP.	Adenosine Diphosphate	132-135	uncoupling protein 1	Homo sapiens	59-63
32210919-4	2020	Activating fatty acids overcome constitutive inhibition of UCP1 by the di- and triphosphate forms of purine nucleotides, i.e., ATP, ADP, GTP, and GDP.	Guanosine Triphosphate	137-140	uncoupling protein 1	Homo sapiens	59-63
32210919-4	2020	Activating fatty acids overcome constitutive inhibition of UCP1 by the di- and triphosphate forms of purine nucleotides, i.e., ATP, ADP, GTP, and GDP.	Guanosine Diphosphate	146-149	uncoupling protein 1	Homo sapiens	59-63
31721030-5	2020	Preadipocytes that were treated with polychlorinated biphenyl congener 126 (PCB126), followed by differentiation, were suppressed for their ability to activate UCP1 upon beta-adrenergic stimulation with norepinephrine (NE), demonstrating a block in the beiging response.	Polychlorinated Biphenyls	37-61	uncoupling protein 1	Homo sapiens	160-164
31721030-5	2020	Preadipocytes that were treated with polychlorinated biphenyl congener 126 (PCB126), followed by differentiation, were suppressed for their ability to activate UCP1 upon beta-adrenergic stimulation with norepinephrine (NE), demonstrating a block in the beiging response.	Norepinephrine	203-217	uncoupling protein 1	Homo sapiens	160-164
31721030-6	2020	Treatment of preadipocytes with another known endogenous AhR agonist, indoxyl sulfate (IS), followed by differentiation also blocked the NE-stimulated upregulation of UCP1.	Indican	70-85	uncoupling protein 1	Homo sapiens	167-171
31721030-6	2020	Treatment of preadipocytes with another known endogenous AhR agonist, indoxyl sulfate (IS), followed by differentiation also blocked the NE-stimulated upregulation of UCP1.	Indican	87-89	uncoupling protein 1	Homo sapiens	167-171
31965068-6	2020	UCP1 mRNA in SAT was negatively correlated with BMI, total abdominal fat area, visceral fat area, blood pressure, fasting glucose, insulin, HOMA-IR score, triglyceride, hsCRP, fasting leptin levels, and adipocyte size.	Triglycerides	155-167	uncoupling protein 1	Homo sapiens	0-4
32085605-8	2020	Moreover, gene expression analysis found that treatment with FLE resulted in upregulation of uncoupling protein 1 (UCP1) and carnitine palmitoyltransferase 1B (CPT1B) genes, which encode proteins favoring mitochondrial ATP production through oxidative phosphorylation and lipid beta-oxidation, respectively.	Adenosine Triphosphate	219-222	uncoupling protein 1	Homo sapiens	93-113
31965068-6	2020	UCP1 mRNA in SAT was negatively correlated with BMI, total abdominal fat area, visceral fat area, blood pressure, fasting glucose, insulin, HOMA-IR score, triglyceride, hsCRP, fasting leptin levels, and adipocyte size.	Glucose	122-129	uncoupling protein 1	Homo sapiens	0-4
31670603-1	2020	Our studies in primary human adipocytes show that naringenin, a citrus flavonoid, increases oxygen consumption rate and gene expression of uncoupling protein 1 (UCP1), glucose transporter type 4, and carnitine palmitoyltransferase 1beta (CPT1beta).	naringenin	50-60	uncoupling protein 1	Homo sapiens	139-159
31670603-1	2020	Our studies in primary human adipocytes show that naringenin, a citrus flavonoid, increases oxygen consumption rate and gene expression of uncoupling protein 1 (UCP1), glucose transporter type 4, and carnitine palmitoyltransferase 1beta (CPT1beta).	naringenin	50-60	uncoupling protein 1	Homo sapiens	161-165
31670603-1	2020	Our studies in primary human adipocytes show that naringenin, a citrus flavonoid, increases oxygen consumption rate and gene expression of uncoupling protein 1 (UCP1), glucose transporter type 4, and carnitine palmitoyltransferase 1beta (CPT1beta).	Flavonoids	71-80	uncoupling protein 1	Homo sapiens	139-159
31670603-1	2020	Our studies in primary human adipocytes show that naringenin, a citrus flavonoid, increases oxygen consumption rate and gene expression of uncoupling protein 1 (UCP1), glucose transporter type 4, and carnitine palmitoyltransferase 1beta (CPT1beta).	Flavonoids	71-80	uncoupling protein 1	Homo sapiens	161-165
31965068-8	2020	UCP1 mRNA in VAT was negatively correlated with visceral-to-subcutaneous fat ratio (VSR), fasting glucose, and triglyceride levels.	Glucose	98-105	uncoupling protein 1	Homo sapiens	0-4
31965068-8	2020	UCP1 mRNA in VAT was negatively correlated with visceral-to-subcutaneous fat ratio (VSR), fasting glucose, and triglyceride levels.	Triglycerides	111-123	uncoupling protein 1	Homo sapiens	0-4
31965068-11	2020	UCP1 mRNA expression in differentiated human white adipocytes was significantly reduced after incubation with thapsigargin, tunicamycin, homocysteine, TNF-alpha, or IL-beta, and significantly increased after incubation with exendin 4, dapagliflozin, and telmisartan.	Thapsigargin	110-122	uncoupling protein 1	Homo sapiens	0-4
31965068-11	2020	UCP1 mRNA expression in differentiated human white adipocytes was significantly reduced after incubation with thapsigargin, tunicamycin, homocysteine, TNF-alpha, or IL-beta, and significantly increased after incubation with exendin 4, dapagliflozin, and telmisartan.	Tunicamycin	124-135	uncoupling protein 1	Homo sapiens	0-4
31965068-11	2020	UCP1 mRNA expression in differentiated human white adipocytes was significantly reduced after incubation with thapsigargin, tunicamycin, homocysteine, TNF-alpha, or IL-beta, and significantly increased after incubation with exendin 4, dapagliflozin, and telmisartan.	Homocysteine	137-149	uncoupling protein 1	Homo sapiens	0-4
31965068-11	2020	UCP1 mRNA expression in differentiated human white adipocytes was significantly reduced after incubation with thapsigargin, tunicamycin, homocysteine, TNF-alpha, or IL-beta, and significantly increased after incubation with exendin 4, dapagliflozin, and telmisartan.	dapagliflozin	235-248	uncoupling protein 1	Homo sapiens	0-4
31965068-11	2020	UCP1 mRNA expression in differentiated human white adipocytes was significantly reduced after incubation with thapsigargin, tunicamycin, homocysteine, TNF-alpha, or IL-beta, and significantly increased after incubation with exendin 4, dapagliflozin, and telmisartan.	telmisartan	254-265	uncoupling protein 1	Homo sapiens	0-4
32085605-8	2020	Moreover, gene expression analysis found that treatment with FLE resulted in upregulation of uncoupling protein 1 (UCP1) and carnitine palmitoyltransferase 1B (CPT1B) genes, which encode proteins favoring mitochondrial ATP production through oxidative phosphorylation and lipid beta-oxidation, respectively.	Adenosine Triphosphate	219-222	uncoupling protein 1	Homo sapiens	115-119
31914415-3	2020	At the cellular level, thermogenesis is achieved through increased rates of futile cycling, which are observed in several systems, most notably the regulated uncoupling of oxidative phosphorylation from ATP generation by uncoupling protein 1, a tissue-specific protein present in mitochondria of brown adipose tissue (BAT).	Adenosine Triphosphate	203-206	uncoupling protein 1	Homo sapiens	221-241
32059055-6	2020	In recent years, it has become clear that multiple thermogenic mechanisms exist, based on ATP sinks centered on creatine, lipid, or calcium cycling, along with Fatty acid-mediated UCP1-independent leak pathways driven by the ADP/ATP carrier (AAC).	Fatty Acids	160-170	uncoupling protein 1	Homo sapiens	180-184
32028915-7	2020	RESULTS: Three SNPs of UCP1: rs7688743 (A allele, OR = 1.192, p = 0.013), rs3811787 (T allele, OR = 0.863, p = 0.023), and rs10011540 (G allele, OR = 1.368, p = 0.004) showed association with DR after the adjustment of glucose, but only rs10011540 was marginally significantly associated with DR when Bonferroni correction was strictly applied (padj = 0.048).	Glucose	219-226	uncoupling protein 1	Homo sapiens	23-27
32028915-10	2020	In patients with uncontrolled glucose, the rs3811787 of UCP1 (T allele, p = 0.017, OR = 0.467) and the rs591758 of UCP3 (C allele, p = 0.026, OR = 0.103) were associated with STDR.	Glucose	30-37	uncoupling protein 1	Homo sapiens	56-60
32028915-11	2020	While in those with well controlled glucose, only the rs7688743 of UCP1 showed a protective effect (A allele, p = 0.024, OR = 0.049).	Glucose	36-43	uncoupling protein 1	Homo sapiens	67-71
32188382-8	2020	CONCLUSION: Based on the above results, we deduced chlorogenic acid could improve blood lipid and liver function in obese, the mechanism may be related to PGC-1alpha/UCP-1 pathway.	Chlorogenic Acid	51-67	uncoupling protein 1	Homo sapiens	166-171
31294462-0	2020	Resveratrol and HIV-protease inhibitors control UCP1 expression through opposite effects on p38 MAPK phosphorylation in human adipocytes.	Resveratrol	0-11	uncoupling protein 1	Homo sapiens	48-52
31294462-10	2020	In contrast, low doses of resveratrol stimulated the activatable expression of UCP1 in a p38 MAPK-dependent manner and counteracted the LPV induced loss of UCP1.	Resveratrol	26-37	uncoupling protein 1	Homo sapiens	79-83
31294462-10	2020	In contrast, low doses of resveratrol stimulated the activatable expression of UCP1 in a p38 MAPK-dependent manner and counteracted the LPV induced loss of UCP1.	Resveratrol	26-37	uncoupling protein 1	Homo sapiens	156-160
31785208-9	2020	CONCLUSIONS: Apg plays a protective role against inflammation-induced suppression of adipocyte browning by dampening inflammation and activating COX2/PGE2 axis for UCP1 induction via EP4 activation.	Apigenin	13-16	uncoupling protein 1	Homo sapiens	164-168
33307890-8	2020	In BA, the thermogenic genes UCP1, PPARgamma, PGC1alpha and GADD45gamma were transcriptionally increased by Meth in a ROS-dependent manner.	Methamphetamine	108-112	uncoupling protein 1	Homo sapiens	29-33
33307890-8	2020	In BA, the thermogenic genes UCP1, PPARgamma, PGC1alpha and GADD45gamma were transcriptionally increased by Meth in a ROS-dependent manner.	Reactive Oxygen Species	118-121	uncoupling protein 1	Homo sapiens	29-33
31785208-9	2020	CONCLUSIONS: Apg plays a protective role against inflammation-induced suppression of adipocyte browning by dampening inflammation and activating COX2/PGE2 axis for UCP1 induction via EP4 activation.	Dinoprostone	150-154	uncoupling protein 1	Homo sapiens	164-168
31361970-6	2019	This could be prevented by guanosine 5"-diphosphate inhibition of UCP1.	Guanosine Diphosphate	27-51	uncoupling protein 1	Homo sapiens	66-70
30463471-3	2019	Primary environmental stimuli of UCP1 include cold-exposure and diet, leading to increased activity of the sympathetic nervous system and large amounts of lipid and glucose being oxidised by brown fat.	Glucose	165-172	uncoupling protein 1	Homo sapiens	33-37
31755337-4	2019	This study showed that an acetone precipitation method had advantages over conventional methods for eliminating lipid contaminants, achieving clear Western blot bands for WAT proteins, especially UCP1.	Acetone	26-33	uncoupling protein 1	Homo sapiens	196-200
31382214-0	2019	Elevated UCP1 levels are sufficient to improve glucose uptake in human white adipocytes.	Glucose	47-54	uncoupling protein 1	Homo sapiens	9-13
31469445-3	2019	Here, we demonstrate that melatonin activates transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1A (PGC1A) and uncoupling protein 1 (UCP1)-dependent lipid autophagy and a lipid browning program to elicit a catabolic state called "tumor slimming," thus suppressing tumor progression.	Melatonin	26-35	uncoupling protein 1	Homo sapiens	150-176
31469445-8	2019	Additional studies indicated that melatonin promoted "tumor slimming" and suppressed ccRCC progression through PGC1A/UCP1-mediated autophagy and lipid browning.	Melatonin	34-43	uncoupling protein 1	Homo sapiens	117-121
31469445-10	2019	These studies demonstrate that the novel "tumor slimming" pathway mediated by melatonin/PGC1A/UCP1 exhibits prognostic potential in ccRCC, thus revealing the significance of monitoring and manipulating this pathway for cancer therapy.	Melatonin	78-87	uncoupling protein 1	Homo sapiens	94-98
31264791-3	2019	Remarkably, Reside Lys126 formed hydrogen bond; residues Pro121, Val125, Tyr146, Tyr149 and Arg150 formed hydrophobic interaction, which are key amino acids within UCP1 site.	Hydrogen	33-41	uncoupling protein 1	Homo sapiens	164-168
31264791-6	2019	In vitro assay indicated ZINC 04660290 significantly increased the protein expression of UCP1 and decreased the fat droplet in a dose-dependent manner.	zinc 04660290	25-38	uncoupling protein 1	Homo sapiens	89-93
31251940-8	2019	Furthermore, Olaparib induced mitochondrial biogenesis in white adipocytes and enhanced UCP1 expression.	olaparib	13-21	uncoupling protein 1	Homo sapiens	88-92
31382214-3	2019	Here, we demonstrate in human white adipocytes that basal/resting glucose uptake is improved by solely elevating UCP1 protein levels.	Glucose	66-73	uncoupling protein 1	Homo sapiens	113-117
31382214-4	2019	Generating human white Simpson-Golabi-Behmel syndrome (SGBS) adipocytes with a stable knockout and overexpression of UCP1, we discovered that UCP1 overexpressing adipocytes significantly improve glucose uptake by 40%.	Glucose	195-202	uncoupling protein 1	Homo sapiens	142-146
31382214-8	2019	Collectively, our data demonstrate that elevating UCP1 levels is sufficient to improve human white adipocytes as a glucose sink without adverse cellular effects, thus not requiring the adrenergic controlled, complex network of browning which usually hampers translational efforts.	Glucose	115-122	uncoupling protein 1	Homo sapiens	50-54
31230192-1	2019	Brown and its related beige adipose tissue (BAT) play a definitive role in maintaining body temperature by producing heat through uncoupling protein 1 (UCP1), which acts by dissociating oxidative phosphorylation from ATP production, resulting in the release of heat.	Adenosine Triphosphate	217-220	uncoupling protein 1	Homo sapiens	130-150
31306668-5	2019	BAT is the only tissue that expresses uncoupling protein 1, conferring on this tissue high thermogenic capacity due to a low efficiency for mitochondrial ATP generation.	Adenosine Triphosphate	154-157	uncoupling protein 1	Homo sapiens	38-58
31215681-4	2019	Treatment with ATRA during the early and late stage of adipogenesis resulted in an increase in the expression level of Ucp1 and Cidea, genes highly expressed in brown adipocytes, on day 8 and day 12, respectively, whereas expression of Pgc-1alpha, another gene expressed during brown adipogenesis, was unaffected by ATRA.	Tretinoin	15-19	uncoupling protein 1	Homo sapiens	119-123
31215681-11	2019	SIGNIFICANCE OF THE STUDY: Significance of the study treatment with all-trans retinoic acid (ATRA) during the early and late stage of adipogenesis increased the expression of Ucp1 and Cidea, genes highly expressed in brown adipocytes, on day 8 and day 12.	Tretinoin	68-91	uncoupling protein 1	Homo sapiens	175-179
31215681-11	2019	SIGNIFICANCE OF THE STUDY: Significance of the study treatment with all-trans retinoic acid (ATRA) during the early and late stage of adipogenesis increased the expression of Ucp1 and Cidea, genes highly expressed in brown adipocytes, on day 8 and day 12.	Tretinoin	93-97	uncoupling protein 1	Homo sapiens	175-179
31235722-1	2019	Brown adipose tissue (BAT) is able to rapidly generate heat and metabolise macronutrients, such as glucose and lipids, through activation of mitochondrial uncoupling protein 1 (UCP1).	Glucose	99-106	uncoupling protein 1	Homo sapiens	177-181
31235722-5	2019	Stem cell-derived adipocytes exposed to caffeine (1 mM) showed increased UCP1 protein abundance and cell metabolism with enhanced oxygen consumption and proton leak.	Caffeine	40-48	uncoupling protein 1	Homo sapiens	73-77
31005563-2	2019	Metabolic reprogramming requires readily available bioenergetics substrates, such as glucose and fatty acids, to increase mitochondrial respiration and produce heat via the uncoupling protein 1 (UCP1).	Glucose	85-92	uncoupling protein 1	Homo sapiens	173-193
31005563-2	2019	Metabolic reprogramming requires readily available bioenergetics substrates, such as glucose and fatty acids, to increase mitochondrial respiration and produce heat via the uncoupling protein 1 (UCP1).	Glucose	85-92	uncoupling protein 1	Homo sapiens	195-199
31005563-2	2019	Metabolic reprogramming requires readily available bioenergetics substrates, such as glucose and fatty acids, to increase mitochondrial respiration and produce heat via the uncoupling protein 1 (UCP1).	Fatty Acids	97-108	uncoupling protein 1	Homo sapiens	173-193
31005563-2	2019	Metabolic reprogramming requires readily available bioenergetics substrates, such as glucose and fatty acids, to increase mitochondrial respiration and produce heat via the uncoupling protein 1 (UCP1).	Fatty Acids	97-108	uncoupling protein 1	Homo sapiens	195-199
31005563-7	2019	MAJOR CONCLUSIONS: Thermogenesis synchronizes fuel oxidation with an acute and transient increase of mitochondrial ROS that promotes the activation of redox-sensitive thermogenic signaling cascade and UCP1.	Reactive Oxygen Species	115-118	uncoupling protein 1	Homo sapiens	201-205
31230192-1	2019	Brown and its related beige adipose tissue (BAT) play a definitive role in maintaining body temperature by producing heat through uncoupling protein 1 (UCP1), which acts by dissociating oxidative phosphorylation from ATP production, resulting in the release of heat.	Adenosine Triphosphate	217-220	uncoupling protein 1	Homo sapiens	152-156
31114671-1	2019	Background: Uncoupling protein 1 (UCP1) is a mitochondral protein transporter that uncouples electron transport from ATP production.	Adenosine Triphosphate	117-120	uncoupling protein 1	Homo sapiens	12-32
31000437-5	2019	Mutation of the two succinylated lysines in UCP1 to acyl-mimetic glutamine and glutamic acid significantly decreases its stability and activity.	Lysine	33-40	uncoupling protein 1	Homo sapiens	44-48
31000437-5	2019	Mutation of the two succinylated lysines in UCP1 to acyl-mimetic glutamine and glutamic acid significantly decreases its stability and activity.	Glutamine	65-74	uncoupling protein 1	Homo sapiens	44-48
31000437-5	2019	Mutation of the two succinylated lysines in UCP1 to acyl-mimetic glutamine and glutamic acid significantly decreases its stability and activity.	Glutamic Acid	79-92	uncoupling protein 1	Homo sapiens	44-48
31114671-1	2019	Background: Uncoupling protein 1 (UCP1) is a mitochondral protein transporter that uncouples electron transport from ATP production.	Adenosine Triphosphate	117-120	uncoupling protein 1	Homo sapiens	34-38
30939798-6	2019	We found that in the cellular levels, FS treatment significantly increased UCP1 expression and BAT activity in human brown adipocytes.	Fluvastatin	38-40	uncoupling protein 1	Homo sapiens	75-79
30950462-4	2019	ZEA treated adipocytes demonstrated a brown-like pattern, with upregulated expression of uncoupling protein 1 (UCP1) and other brown adipocyte markers.	Zeaxanthins	0-3	uncoupling protein 1	Homo sapiens	89-109
30950462-4	2019	ZEA treated adipocytes demonstrated a brown-like pattern, with upregulated expression of uncoupling protein 1 (UCP1) and other brown adipocyte markers.	Zeaxanthins	0-3	uncoupling protein 1	Homo sapiens	111-115
30996144-6	2019	Although eAT exhibited a depot-specific upregulation in the immune-related pathways relative to mAT and sAT, high UCP1 expression in eAT was specifically associated with differential gene expression that functionally corresponded with downregulation in the production of reactive oxygen species and immune responses, including T cell homeostasis.	reactive	271-279	uncoupling protein 1	Homo sapiens	114-118
30996144-6	2019	Although eAT exhibited a depot-specific upregulation in the immune-related pathways relative to mAT and sAT, high UCP1 expression in eAT was specifically associated with differential gene expression that functionally corresponded with downregulation in the production of reactive oxygen species and immune responses, including T cell homeostasis.	oxygen species	280-294	uncoupling protein 1	Homo sapiens	114-118
30967578-7	2019	Thermogenesis potential resulted from PPARgamma stimulation, irisin and BMP7 can be activated in UCP1-dependent and the beige specific, creatine phosphate cycle mediated way.	Phosphocreatine	136-154	uncoupling protein 1	Homo sapiens	97-101
30635274-1	2019	Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1.	celastrol	0-9	uncoupling protein 1	Homo sapiens	75-79
30708100-3	2019	Using the Ucp1-2A-luciferase reporter animal model previously reported by us as a screening platform, a chemical compound Linifanib was identified as a potent inducer of UCP1 expression in primary inguinal adipocytes in vitro and in vivo.	N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea	122-131	uncoupling protein 1	Homo sapiens	10-14
30708100-3	2019	Using the Ucp1-2A-luciferase reporter animal model previously reported by us as a screening platform, a chemical compound Linifanib was identified as a potent inducer of UCP1 expression in primary inguinal adipocytes in vitro and in vivo.	N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea	122-131	uncoupling protein 1	Homo sapiens	170-174
30949296-10	2019	These data and the expression of UCP1 protein, indicated that SP pretreatment produced a bias toward brown adipocyte differentiation.	sp	62-64	uncoupling protein 1	Homo sapiens	33-37
30414927-3	2019	Recent molecular aspects of UCP1 structure provide support for the fatty acid cycling model of coupling, i.e. when UCP1 expels fatty acid anions in a uniport mode from the matrix, while uncoupling.	Fatty Acids	67-77	uncoupling protein 1	Homo sapiens	28-32
30414927-3	2019	Recent molecular aspects of UCP1 structure provide support for the fatty acid cycling model of coupling, i.e. when UCP1 expels fatty acid anions in a uniport mode from the matrix, while uncoupling.	Fatty Acids	67-77	uncoupling protein 1	Homo sapiens	115-119
30414927-3	2019	Recent molecular aspects of UCP1 structure provide support for the fatty acid cycling model of coupling, i.e. when UCP1 expels fatty acid anions in a uniport mode from the matrix, while uncoupling.	Fatty Acids	127-137	uncoupling protein 1	Homo sapiens	28-32
30414927-3	2019	Recent molecular aspects of UCP1 structure provide support for the fatty acid cycling model of coupling, i.e. when UCP1 expels fatty acid anions in a uniport mode from the matrix, while uncoupling.	Fatty Acids	127-137	uncoupling protein 1	Homo sapiens	115-119
30414927-8	2019	We discuss circumstances under which promotion of superoxide formation exceeds its attenuation by uncoupling in mitochondria and throughout point out areas of future research into UCP1 function.	Superoxides	50-60	uncoupling protein 1	Homo sapiens	180-184
31131187-6	2019	Further studies show that PLCL1 promotes tumor cell "slimming" and represses tumor progression through UCP1-mediated lipid browning, which consumes lipids without producing ATP energy.	Adenosine Triphosphate	173-176	uncoupling protein 1	Homo sapiens	103-107
29797089-3	2019	As an uncoupling protein, UCP1 transports H+ across the IMM in presence of long-chain fatty acids (FA), which makes brown fat mitochondria produce heat at the expense of ATP.	Adenosine Triphosphate	170-173	uncoupling protein 1	Homo sapiens	26-30
31089582-0	2019	Quercetin Upregulates Uncoupling Protein 1 in White/Brown Adipose Tissues through Sympathetic Stimulation (J Obes Metab Syndr 2018;27:102-9).	Quercetin	0-9	uncoupling protein 1	Homo sapiens	22-42
31089583-0	2019	Quercetin Upregulates Uncoupling Protein 1 in White/Brown Adipose Tissues through Sympathetic Stimulation (J Obes Metab Syndr 2018;27:102-9).	Quercetin	0-9	uncoupling protein 1	Homo sapiens	22-42
30759876-4	2019	This uncoupling protein 1 (UCP1)-mediated process requires input from sympathetic nerves releasing norepinephrine.	Norepinephrine	99-113	uncoupling protein 1	Homo sapiens	5-25
30759876-4	2019	This uncoupling protein 1 (UCP1)-mediated process requires input from sympathetic nerves releasing norepinephrine.	Norepinephrine	99-113	uncoupling protein 1	Homo sapiens	27-31
30450758-2	2019	Brown and beige (or brite) adipocytes express high levels of uncoupling protein 1 (Ucp1) to dissipate heat instead of generating ATP.	Adenosine Triphosphate	129-132	uncoupling protein 1	Homo sapiens	83-87
29797089-3	2019	As an uncoupling protein, UCP1 transports H+ across the IMM in presence of long-chain fatty acids (FA), which makes brown fat mitochondria produce heat at the expense of ATP.	long-chain fatty acids	75-97	uncoupling protein 1	Homo sapiens	26-30
30141101-1	2019	Fatty acids are essential contributors to adipocyte-based non-shivering thermogenesis by acting as activators of uncoupling protein 1 and serving as fuel for mitochondrial heat production.	Fatty Acids	0-11	uncoupling protein 1	Homo sapiens	113-133
30506905-7	2019	RESULTS: In hADSC, naringenin increased expression of the genes associated with thermogenesis and fat oxidation, including uncoupling protein 1 and adipose triglyceride lipase, and key factors associated with insulin sensitivity, including glucose transporter type 4, adiponectin, and carbohydrate-responsive element-binding protein (P &lt; 0.01).	naringenin	19-29	uncoupling protein 1	Homo sapiens	123-143
30411385-11	2018	Treatment with 17beta-estradiol during the early stage of brown adipogenesis enhanced the responsiveness to isoproterenol (Iso), an agonist for the beta-adrenergic receptor, on Ucp1 induction, whereas treatment during the late stage of brown adipogenesis decreased Ucp1 expression in unstimulated brown adipocytes.	Estradiol	15-31	uncoupling protein 1	Homo sapiens	177-181
30411385-0	2018	Role of estradiol and testosterone in Ucp1 expression in brown/beige adipocytes.	Estradiol	8-17	uncoupling protein 1	Homo sapiens	38-42
30411385-0	2018	Role of estradiol and testosterone in Ucp1 expression in brown/beige adipocytes.	Testosterone	22-34	uncoupling protein 1	Homo sapiens	38-42
30411385-6	2018	Treatment with 17beta-estradiol during the early stage of brown adipogenesis enhanced the responsiveness to Iso on Ucp1 induction, whereas treatment during the late stage of brown adipogenesis decreased Ucp1 expression in unstimulated brown adipocytes.	Estradiol	15-31	uncoupling protein 1	Homo sapiens	115-119
30411385-7	2018	Estradiol decreased Iso-induced Ucp1 expression during the early stage of beige adipogenesis.	Estradiol	0-9	uncoupling protein 1	Homo sapiens	32-36
30411385-11	2018	Treatment with 17beta-estradiol during the early stage of brown adipogenesis enhanced the responsiveness to isoproterenol (Iso), an agonist for the beta-adrenergic receptor, on Ucp1 induction, whereas treatment during the late stage of brown adipogenesis decreased Ucp1 expression in unstimulated brown adipocytes.	Estradiol	15-31	uncoupling protein 1	Homo sapiens	265-269
30411385-8	2018	Treatment with testosterone during the early stage of brown adipogenesis did not affect Ucp1 expression but increased the responsiveness to Iso on Ucp1 induction by the treatment during the late stage of brown adipogenesis.	Testosterone	15-27	uncoupling protein 1	Homo sapiens	147-151
30411385-11	2018	Treatment with 17beta-estradiol during the early stage of brown adipogenesis enhanced the responsiveness to isoproterenol (Iso), an agonist for the beta-adrenergic receptor, on Ucp1 induction, whereas treatment during the late stage of brown adipogenesis decreased Ucp1 expression in unstimulated brown adipocytes.	Isoproterenol	108-121	uncoupling protein 1	Homo sapiens	177-181
30411385-11	2018	Treatment with 17beta-estradiol during the early stage of brown adipogenesis enhanced the responsiveness to isoproterenol (Iso), an agonist for the beta-adrenergic receptor, on Ucp1 induction, whereas treatment during the late stage of brown adipogenesis decreased Ucp1 expression in unstimulated brown adipocytes.	Isoproterenol	108-121	uncoupling protein 1	Homo sapiens	265-269
30411385-11	2018	Treatment with 17beta-estradiol during the early stage of brown adipogenesis enhanced the responsiveness to isoproterenol (Iso), an agonist for the beta-adrenergic receptor, on Ucp1 induction, whereas treatment during the late stage of brown adipogenesis decreased Ucp1 expression in unstimulated brown adipocytes.	Isoproterenol	123-126	uncoupling protein 1	Homo sapiens	177-181
30411385-11	2018	Treatment with 17beta-estradiol during the early stage of brown adipogenesis enhanced the responsiveness to isoproterenol (Iso), an agonist for the beta-adrenergic receptor, on Ucp1 induction, whereas treatment during the late stage of brown adipogenesis decreased Ucp1 expression in unstimulated brown adipocytes.	Isoproterenol	123-126	uncoupling protein 1	Homo sapiens	265-269
30411385-12	2018	Estradiol decreased Iso-induced Ucp1 expression during the early stage of beige adipogenesis.	Estradiol	0-9	uncoupling protein 1	Homo sapiens	32-36
30411385-13	2018	Testosterone during the late stage of brown adipogenesis increased the responsiveness to Iso on Ucp1 induction.	Testosterone	0-12	uncoupling protein 1	Homo sapiens	96-100
30217511-2	2018	By dissipating the electrochemical H+ gradient, UCP1 uncouples respiration from ATP synthesis, which drives an increase in substrate oxidation via the TCA cycle flux that generates more heat.	Adenosine Triphosphate	80-83	uncoupling protein 1	Homo sapiens	48-52
30456392-4	2018	From the resulting model, we delineate that in brown adipocytes (1) free fatty acids are a significant contributor to extracellular acidification, (2) glycogen is the dominant glycolytic substrate source in the acute response to an adrenergic stimulus, and (3) the futile cycling of free fatty acids between lipolysis and re-esterification into triglyceride provides a mechanism for uncoupling protein 1-independent, non-shivering thermogenesis in brown adipocytes.	Glycogen	151-159	uncoupling protein 1	Homo sapiens	383-403
30217511-2	2018	By dissipating the electrochemical H+ gradient, UCP1 uncouples respiration from ATP synthesis, which drives an increase in substrate oxidation via the TCA cycle flux that generates more heat.	Trichloroacetic Acid	151-154	uncoupling protein 1	Homo sapiens	48-52
30217511-4	2018	UCP1 is regulated by beta-adrenergic receptors through the sympathetic nervous system and at the molecular activity level by nucleotides and fatty acid to meet thermogenesis needs.	Fatty Acids	141-151	uncoupling protein 1	Homo sapiens	0-4
30176958-0	2018	Programming mediated by fatty acids affects uncoupling protein 1 (UCP-1) in brown adipose tissue.	Fatty Acids	24-35	uncoupling protein 1	Homo sapiens	44-71
29668464-0	2018	Effects of alpha-(prazosin and yohimbine) and beta-receptors activity on cAMP generation and UCP1 gene expression in brown adipocytes.	Yohimbine	31-40	uncoupling protein 1	Homo sapiens	93-97
30233783-8	2018	Two cardiolipin-binding lysines (K175 and K269) of UCP1 may be crucial for this UCP1-cardiolipin recognition and UCP1 function.	Lysine	24-31	uncoupling protein 1	Homo sapiens	51-55
30233783-8	2018	Two cardiolipin-binding lysines (K175 and K269) of UCP1 may be crucial for this UCP1-cardiolipin recognition and UCP1 function.	Lysine	24-31	uncoupling protein 1	Homo sapiens	80-84
30233783-8	2018	Two cardiolipin-binding lysines (K175 and K269) of UCP1 may be crucial for this UCP1-cardiolipin recognition and UCP1 function.	Lysine	24-31	uncoupling protein 1	Homo sapiens	80-84
29859845-5	2018	There is strong evidence that UCP2 and UCP3, the UCP1 homologues expressed in the heart, protect against mitochondrial oxidative damage by reducing the production of ROS.	Reactive Oxygen Species	166-169	uncoupling protein 1	Homo sapiens	49-53
30176958-5	2018	There is much to discover yet about the role of different fatty acids on the development of BAT and the activation of UCP-1 during the fetal and the postnatal periods of life.	Fatty Acids	58-69	uncoupling protein 1	Homo sapiens	118-123
29796650-7	2018	The 5,10,15,20-tetra(N-methyl-4-pyridyl) porphyrin (TMPyP4) enhanced cellular expression of UCP1 and destabilized the G-quadruplex formed by the sequence from the promoter of UCP1.	tetra(4-N-methylpyridyl)porphine	52-58	uncoupling protein 1	Homo sapiens	92-96
30166563-3	2018	Here, we find that pan-HDACi TSA exerts paradoxical effects on brown fat gene expression, as it inhibits the expression of Ucp1, Ppargamma and Prdm16 in brown adipocytes, while promoting the expression of other brown fat-specific genes such as Pgc1alpha, Pgc1beta, Acox1 and Cidea.	trichostatin A	29-32	uncoupling protein 1	Homo sapiens	123-127
30030465-3	2018	Here we described that specific ablation of cAMP production in brown adipocytes led to reduced lipolysis, mitochondrial biogenesis, uncoupling protein 1 (Ucp1) expression, and consequently defective adaptive thermogenesis.	Cyclic AMP	44-48	uncoupling protein 1	Homo sapiens	154-158
30079236-1	2018	Brown adipose tissue (BAT) possesses a unique uncoupling protein (UCP1) which, when activated, enables the rapid generation of heat and the oxidation of lipids or glucose or both.	Glucose	163-170	uncoupling protein 1	Homo sapiens	66-70
29796650-7	2018	The 5,10,15,20-tetra(N-methyl-4-pyridyl) porphyrin (TMPyP4) enhanced cellular expression of UCP1 and destabilized the G-quadruplex formed by the sequence from the promoter of UCP1.	tetra(4-N-methylpyridyl)porphine	52-58	uncoupling protein 1	Homo sapiens	175-179
29868672-5	2018	Interestingly, EGCG elicited iWAT-preadipocyte-derived mature white adipocyte beiging via activating thermogenic gene Ucp1 expression and mitochondrial biogenesis.	epigallocatechin gallate	15-19	uncoupling protein 1	Homo sapiens	118-122
29744695-9	2018	H-89, a specific PKA inhibitor, abrogated bLF-induced UCP1 gene expression.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	0-4	uncoupling protein 1	Homo sapiens	54-58
29946343-9	2018	XN activated AMPK and in turn, XN-induced upregulation of UCP1, p-ACC, HSL, and ATGL was downregulated in the presence of dorsomorphin.	xanthohumol	0-2	uncoupling protein 1	Homo sapiens	58-62
29946343-9	2018	XN activated AMPK and in turn, XN-induced upregulation of UCP1, p-ACC, HSL, and ATGL was downregulated in the presence of dorsomorphin.	xanthohumol	31-33	uncoupling protein 1	Homo sapiens	58-62
29946343-9	2018	XN activated AMPK and in turn, XN-induced upregulation of UCP1, p-ACC, HSL, and ATGL was downregulated in the presence of dorsomorphin.	dorsomorphin	122-134	uncoupling protein 1	Homo sapiens	58-62
29744695-11	2018	These results suggest that bLF promotes UCP1 gene expression in brown adipocytes through the cAMP-PKA signaling pathway via the LRP1 receptor, leading to increased energy expenditure.	Cyclic AMP	93-97	uncoupling protein 1	Homo sapiens	40-44
29772784-5	2018	These responses of capsaicin are mediated through activation of TRPV1, which can then modulate processes such as browning of adipocytes, and activation of metabolic modulators including AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor alpha (PPARalpha), uncoupling protein 1 (UCP1), and glucagon-like peptide 1 (GLP-1).	Capsaicin	19-28	uncoupling protein 1	Homo sapiens	285-305
29638041-2	2018	Here, we report that L-rhamnose induced browning by elevating expression levels of beige-specific marker genes, including Cd137, Cited1, Tbx1, Prdm16, Tmem26, and Ucp1, in 3T3-L1 adipocytes.	Rhamnose	21-31	uncoupling protein 1	Homo sapiens	163-167
29785025-4	2018	CHRNA2 functioned selectively in uncoupling protein 1 (Ucp1)-positive beige adipocytes, increasing thermogenesis through a cAMP- and protein kinase A-dependent pathway.	Cyclic AMP	123-127	uncoupling protein 1	Homo sapiens	55-59
29547798-4	2018	RESULTS: Magnolol significantly enhanced expression of a core set of brown fat-specific marker genes (Ucp1, Cd137, Prdm16, Cidea, and Tbx1) and proteins (UCP1, PRDM16, and PGC-1alpha).	magnolol	9-17	uncoupling protein 1	Homo sapiens	102-106
29547798-4	2018	RESULTS: Magnolol significantly enhanced expression of a core set of brown fat-specific marker genes (Ucp1, Cd137, Prdm16, Cidea, and Tbx1) and proteins (UCP1, PRDM16, and PGC-1alpha).	magnolol	9-17	uncoupling protein 1	Homo sapiens	154-158
29772784-5	2018	These responses of capsaicin are mediated through activation of TRPV1, which can then modulate processes such as browning of adipocytes, and activation of metabolic modulators including AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor alpha (PPARalpha), uncoupling protein 1 (UCP1), and glucagon-like peptide 1 (GLP-1).	Capsaicin	19-28	uncoupling protein 1	Homo sapiens	307-311
29617639-3	2018	(2018) have recently added another interesting dimension to this by demonstrating that actinomyosin-mediated elasticity regulates the thermogenic capacity of UCP1+ adipocytes, opening up new ways by which UCP1-dependent thermogenesis can be stimulated.	actinomyosin	87-99	uncoupling protein 1	Homo sapiens	158-162
29617639-3	2018	(2018) have recently added another interesting dimension to this by demonstrating that actinomyosin-mediated elasticity regulates the thermogenic capacity of UCP1+ adipocytes, opening up new ways by which UCP1-dependent thermogenesis can be stimulated.	actinomyosin	87-99	uncoupling protein 1	Homo sapiens	205-209
29514884-6	2018	Free fatty acids released by lipolysis are direct activators of uncoupling protein 1-mediated leak respiration.	Fatty Acids, Nonesterified	0-16	uncoupling protein 1	Homo sapiens	64-84
29271697-2	2018	Fatty acids derived from lipid droplets within brown adipocytes acting on mitochondrial uncoupling protein 1 (UCP1) were long thought to be essential for non-shivering thermogenesis.	Fatty Acids	0-11	uncoupling protein 1	Homo sapiens	110-114
29212043-0	2018	Inhibition of mitochondrial UCP1 and UCP3 by purine nucleotides and phosphate.	Purine Nucleotides	45-63	uncoupling protein 1	Homo sapiens	28-32
29212043-0	2018	Inhibition of mitochondrial UCP1 and UCP3 by purine nucleotides and phosphate.	Phosphates	68-77	uncoupling protein 1	Homo sapiens	28-32
29212043-2	2018	In contrast to UCP1, the transport function and molecular mechanism of UCP3 regulation are poorly investigated, although it is generally agreed upon that UCP3, analogous to UCP1, transports protons, is activated by free fatty acids (FFAs) and is inhibited by purine nucleotides (PNs).	Fatty Acids, Nonesterified	215-231	uncoupling protein 1	Homo sapiens	173-177
29212043-2	2018	In contrast to UCP1, the transport function and molecular mechanism of UCP3 regulation are poorly investigated, although it is generally agreed upon that UCP3, analogous to UCP1, transports protons, is activated by free fatty acids (FFAs) and is inhibited by purine nucleotides (PNs).	purine	259-265	uncoupling protein 1	Homo sapiens	173-177
29212043-6	2018	Experiments with mutant proteins demonstrated that the conserved arginines in the PN-binding pocket are involved in the inhibition of UCP1 and UCP3 to different extents.	Arginine	65-74	uncoupling protein 1	Homo sapiens	134-138
29212043-7	2018	Fatty acids compete with all PNs bound to UCP1, but only with ATP bound to UCP3.	Fatty Acids	0-11	uncoupling protein 1	Homo sapiens	42-46
29212043-8	2018	We identified phosphate as a novel inhibitor of UCP3 and UCP1, which acts independently of PNs.	Phosphates	14-23	uncoupling protein 1	Homo sapiens	57-61
29217172-10	2018	Nobiletin-induced browning could be mediated by tight regulation of kinases, as nobiletin induced PKA and p-AMPK at the protein expression level, and inhibition of PKA and p-AMPK by H-89 and dorsomorphin, respectively, abolished expression of the thermogenic markers PGC-1alpha and UCP1.	nobiletin	0-9	uncoupling protein 1	Homo sapiens	282-286
29310935-0	2018	Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity.	Purine Nucleotides	31-49	uncoupling protein 1	Homo sapiens	60-80
29310935-4	2018	We measured the cellular concentration and the release of purine nucleotide metabolites to uncover a possible role of purine nucleotide degradation in uncoupling protein 1 activation.	Purine Nucleotides	118-135	uncoupling protein 1	Homo sapiens	151-171
29310935-11	2018	Pharmacological and genetic interference of purine metabolism altered uncoupling protein 1 mediated uncoupled respiration.	purine	44-50	uncoupling protein 1	Homo sapiens	70-90
29310935-12	2018	CONCLUSION: Adrenergic stimulation of brown adipocytes lowers the intracellular concentration of purine nucleotides, thereby contributing to uncoupling protein 1 activation.	Purine Nucleotides	97-115	uncoupling protein 1	Homo sapiens	141-161
29339762-3	2018	Treatment with capsaicin (100 muM) during brown adipogenesis enhanced lipid accumulation and the expression of Ucp1, a gene selectively expressed in brown adipocytes.	Capsaicin	15-24	uncoupling protein 1	Homo sapiens	111-115
29851009-0	2018	The Importance of Calcium Ions for Determining Mitochondrial Glycerol-3-Phosphate Dehydrogenase Activity When Measuring Uncoupling Protein 1 (UCP1) Function in Mitochondria Isolated from Brown Adipose Tissue.	Calcium	18-25	uncoupling protein 1	Homo sapiens	142-146
28986166-5	2018	RESULTS: The results showed that multilocular UCP1-positive adipocytes existed in sWAT samples from subjects after sildenafil treatment.	Sildenafil Citrate	115-125	uncoupling protein 1	Homo sapiens	46-50
28986166-6	2018	Compared to before treatment in both group as well as after treatment in placebo, sildenafil significantly decreased adipocyte size, increased the expressions of UCP1 protein and mRNA, mitochondrial density, and leak respiratory capacity in sWAT (p&lt;0.05).	Sildenafil Citrate	82-92	uncoupling protein 1	Homo sapiens	162-166
30454587-5	2018	UCP1 is innately inhibited by cytosolic adenosine triphosphate (ATP) and is likely activated by fatty acids released from triglycerides within the cells; this lipolysis is stimulated by norepinephrine released from the sympathetic nerves innervating the tissue.	Adenosine Triphosphate	40-62	uncoupling protein 1	Homo sapiens	0-4
30454587-5	2018	UCP1 is innately inhibited by cytosolic adenosine triphosphate (ATP) and is likely activated by fatty acids released from triglycerides within the cells; this lipolysis is stimulated by norepinephrine released from the sympathetic nerves innervating the tissue.	Adenosine Triphosphate	64-67	uncoupling protein 1	Homo sapiens	0-4
30454587-5	2018	UCP1 is innately inhibited by cytosolic adenosine triphosphate (ATP) and is likely activated by fatty acids released from triglycerides within the cells; this lipolysis is stimulated by norepinephrine released from the sympathetic nerves innervating the tissue.	Fatty Acids	96-107	uncoupling protein 1	Homo sapiens	0-4
30454587-5	2018	UCP1 is innately inhibited by cytosolic adenosine triphosphate (ATP) and is likely activated by fatty acids released from triglycerides within the cells; this lipolysis is stimulated by norepinephrine released from the sympathetic nerves innervating the tissue.	Triglycerides	122-135	uncoupling protein 1	Homo sapiens	0-4
30454587-5	2018	UCP1 is innately inhibited by cytosolic adenosine triphosphate (ATP) and is likely activated by fatty acids released from triglycerides within the cells; this lipolysis is stimulated by norepinephrine released from the sympathetic nerves innervating the tissue.	Norepinephrine	186-200	uncoupling protein 1	Homo sapiens	0-4
29851009-5	2018	This article provides easy-to-follow protocols to facilitate the measurement of mGPDH-dependent UCP1 activity in the presence of calcium for isolated brown adipose tissue mitochondria.	Calcium	129-136	uncoupling protein 1	Homo sapiens	96-100
29851009-4	2018	It was demonstrated that in isolated brown adipose tissue mitochondria (1) mGPDH enzyme activity is maximal at free calcium ion concentrations in the 350 nM-1 muM range, (2) that ROS production also peaks in the 10-100 nM range in the presence of a UCP1 inhibitory ligand (GDP) but wanes with further increasing calcium concentration, and (3) that oxygen consumption rates peak in the 10-100 nM range with rates being maintained at higher calcium concentrations.	ros	179-182	uncoupling protein 1	Homo sapiens	249-253
29131158-0	2017	UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis.	Calcium	54-61	uncoupling protein 1	Homo sapiens	0-4
29131158-2	2017	Here we report a robust UCP1-independent thermogenic mechanism in beige fat that involves enhanced ATP-dependent Ca2+ cycling by sarco/endoplasmic reticulum Ca2+-ATPase 2b (SERCA2b) and ryanodine receptor 2 (RyR2).	Adenosine Triphosphate	99-102	uncoupling protein 1	Homo sapiens	24-28
29136581-5	2017	RESULTS: Honokiol treatment induced browning by elevating expression levels of brown adipocyte-specific genes such as Cidea, Cox8, Fgf21, Pgc-1alpha, and Ucp1.	honokiol	9-17	uncoupling protein 1	Homo sapiens	154-158
29136581-8	2017	Honokiol-induced browning could be mediated by activation of ERK, as inhibition of ERK by FR180204 abolished expression of PGC-1alpha and UCP1.	honokiol	0-8	uncoupling protein 1	Homo sapiens	138-142
28073315-5	2017	ASCs derived from WAT were successfully differentiated in 3D poly(ethylene glycol) hydrogels into mature adipocytes with BAT phenotype and function, including high uncoupling protein 1 (UCP1) mRNA and protein expression and increased metabolic activity (basal oxygen consumption, proton leak, and maximum respiration).	Polyethylene Glycols	61-82	uncoupling protein 1	Homo sapiens	164-184
28827782-5	2017	In contrast, the depletion of calcium in the medium enhances adipogenesis and expression of brown adipocyte selective genes, such as UCP1.	Calcium	30-37	uncoupling protein 1	Homo sapiens	133-137
28416581-7	2017	Conversely, activating TRPM8 with menthol up-regulated UCP-1 expression and augmented uncoupled respiration predominantly in white adipocytes (browning), whereas streptomycin antagonized TRPM8-mediated calcium entry, downregulated UCP-1 expression, and mitigated uncoupled respiration; menthol was less capable of augmenting uncoupled respiration (thermogenesis) in brown adipocytes.	Menthol	34-41	uncoupling protein 1	Homo sapiens	55-60
28710335-0	2017	Uncoupling protein 1 controls reactive oxygen species in brown adipose tissue.	Reactive Oxygen Species	30-53	uncoupling protein 1	Homo sapiens	0-20
28673060-11	2017	s-UCP values less than or equal to 20 cm H2O had a sensitivity of 73.1% and a specificity of 93.0% for predicting SUI.	Water	41-44	uncoupling protein 1	Homo sapiens	2-5
28250021-9	2017	Consistently, the histamine receptor antagonist chlorpheniramine potently inhibited adipocyte UCP1 mRNA induction by mast cell CM.	Chlorpheniramine	48-64	uncoupling protein 1	Homo sapiens	94-98
28469599-14	2017	Surprisingly, TSHR activation in CM also significantly increased pre-BAT marker PRDM16; furthermore, TZD-ADM induced adipogenesis showed substantially increased BAT markers, PGC-1alpha and UCP1.	tzd-adm	101-108	uncoupling protein 1	Homo sapiens	189-193
28380374-0	2017	Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling.	Creatine	115-123	uncoupling protein 1	Homo sapiens	54-58
28380374-0	2017	Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling.	Creatine	115-123	uncoupling protein 1	Homo sapiens	72-76
28380374-7	2017	Despite the absence of UCP1 in the majority of epididymal beige adipocytes, these cells employ prominent creatine cycling as a UCP1-independent thermogenic mechanism.	Creatine	105-113	uncoupling protein 1	Homo sapiens	127-131
29117542-1	2017	We thought we knew how the heat-producing uncoupling protein 1 in brown adipose tissue was activated: by fatty acids released upon lipid droplet breakdown in the brown adipocytes.	Fatty Acids	105-116	uncoupling protein 1	Homo sapiens	42-62
29372106-10	2017	UCP1 and UCP3 are overexpressed in a large subgroup of non-small cell lung tumors and their expression coincides with increased glucose absorption, intensified glycolysis, and anaerobic glucose usage.	Glucose	128-135	uncoupling protein 1	Homo sapiens	0-4
29372106-10	2017	UCP1 and UCP3 are overexpressed in a large subgroup of non-small cell lung tumors and their expression coincides with increased glucose absorption, intensified glycolysis, and anaerobic glucose usage.	Glucose	186-193	uncoupling protein 1	Homo sapiens	0-4
28957413-7	2017	Mature TERT-hWA adipocytes underwent efficient rosiglitazone-induced "browning", as demonstrated by strongly increased expression of UCP1 and other brown adipocyte-enriched genes.	Rosiglitazone	47-60	uncoupling protein 1	Homo sapiens	133-137
28781081-1	2017	The mitochondrial uncoupling protein 1 (UCP1) generates heat by causing proton leak across the mitochondrial inner membrane that requires fatty acid (FA).	Fatty Acids	138-148	uncoupling protein 1	Homo sapiens	40-44
28781081-4	2017	According to the paramagnetic relaxation enhancement data and molecular dynamics simulation, the FA acyl chain appears to fit into the groove between H1 and H6 while the FA carboxylate group interacts with the basic residues near the matrix side of UCP1.	fa carboxylate	170-184	uncoupling protein 1	Homo sapiens	249-253
28827782-7	2017	Moreover, increased extracellular calcium solely after the induction phase of differentiation specifically suppresses gene expression of UCP1, PRDM16 and PGC1-alpha.	Calcium	34-41	uncoupling protein 1	Homo sapiens	137-141
28717127-0	2017	Experimental evidence reveals the UCP1 genotype changes the oxygen consumption attributed to non-shivering thermogenesis in humans.	Oxygen	60-66	uncoupling protein 1	Homo sapiens	34-38
28717127-3	2017	The uncoupling protein 1 (UCP1) gene enhances thermogenesis reaction in a physiological process by blocking ATP (adenosine triphosphate) synthesis on a mitochondrial membrane in brown adipose tissues.	Adenosine Triphosphate	108-111	uncoupling protein 1	Homo sapiens	4-24
28717127-3	2017	The uncoupling protein 1 (UCP1) gene enhances thermogenesis reaction in a physiological process by blocking ATP (adenosine triphosphate) synthesis on a mitochondrial membrane in brown adipose tissues.	Adenosine Triphosphate	108-111	uncoupling protein 1	Homo sapiens	26-30
28717127-3	2017	The uncoupling protein 1 (UCP1) gene enhances thermogenesis reaction in a physiological process by blocking ATP (adenosine triphosphate) synthesis on a mitochondrial membrane in brown adipose tissues.	Adenosine Triphosphate	113-135	uncoupling protein 1	Homo sapiens	4-24
28717127-3	2017	The uncoupling protein 1 (UCP1) gene enhances thermogenesis reaction in a physiological process by blocking ATP (adenosine triphosphate) synthesis on a mitochondrial membrane in brown adipose tissues.	Adenosine Triphosphate	113-135	uncoupling protein 1	Homo sapiens	26-30
28655922-6	2017	Treatment with either isoproterenol or Forskolin further induced the expression of Ucp1, suggesting that beta adrenergic receptor signalling in ciBAs could be functional for induction of thermogenic genes.	Isoproterenol	22-35	uncoupling protein 1	Homo sapiens	83-87
28655922-6	2017	Treatment with either isoproterenol or Forskolin further induced the expression of Ucp1, suggesting that beta adrenergic receptor signalling in ciBAs could be functional for induction of thermogenic genes.	Colforsin	39-48	uncoupling protein 1	Homo sapiens	83-87
28591028-1	2017	The aim of this study is to evaluate the effect of single-nucleotide polymorphisms (SNPs) of the PPARGC1A and UCP1 genes on impaired fasting glucose (IFG) or type 2 diabetes mellitus (T2DM) and the haplotype-based interaction between these genes.A cross-sectional study was conducted by cluster sampling in Henan province, China.	Glucose	141-148	uncoupling protein 1	Homo sapiens	110-114
28591028-3	2017	Kernel canonical correlation analysis (KCCA), a haplotype-based gene-gene interaction method, which can increase the biological interpretability and extract nonlinear characteristics of SNPs, was used to analyze the correlation and interaction between PPARGC1A and UCP1 genes.The age, BMI, total cholesterol and triglycerides were statistically different between 2 groups (P &lt;= .001).	Cholesterol	296-307	uncoupling protein 1	Homo sapiens	265-269
28591028-3	2017	Kernel canonical correlation analysis (KCCA), a haplotype-based gene-gene interaction method, which can increase the biological interpretability and extract nonlinear characteristics of SNPs, was used to analyze the correlation and interaction between PPARGC1A and UCP1 genes.The age, BMI, total cholesterol and triglycerides were statistically different between 2 groups (P &lt;= .001).	Triglycerides	312-325	uncoupling protein 1	Homo sapiens	265-269
28591028-6	2017	A haplotype-based gene-gene interaction was observed significantly (U = -6.28, P &lt; .001), indicating the possibility of an interaction between haplotype AAG of the PPARGC1A gene and haplotypes CTCG (odds ratio [OR] = 1.745, 95% confidence interval [95% CI] 1.069-2.847) and CTCA (OR = 0.239, 95% CI 0.060-0.958) of the UCP1 gene.Haplotype-based interaction between the PPARGC1A and UCP1 genes is associated with IFG or T2DM among residents in Henan, China.	ctcg	196-200	uncoupling protein 1	Homo sapiens	322-326
28591028-6	2017	A haplotype-based gene-gene interaction was observed significantly (U = -6.28, P &lt; .001), indicating the possibility of an interaction between haplotype AAG of the PPARGC1A gene and haplotypes CTCG (odds ratio [OR] = 1.745, 95% confidence interval [95% CI] 1.069-2.847) and CTCA (OR = 0.239, 95% CI 0.060-0.958) of the UCP1 gene.Haplotype-based interaction between the PPARGC1A and UCP1 genes is associated with IFG or T2DM among residents in Henan, China.	ctcg	196-200	uncoupling protein 1	Homo sapiens	385-389
28580291-5	2017	RESULTS: Unexpectedly, we found that beta3-adrenergically induced (by CL-316,243) glucose uptake was UCP1-independent.	Glucose	82-89	uncoupling protein 1	Homo sapiens	101-105
27916641-8	2017	UCP1 is certainly a unique mitochondrial transporter able to uncouple respiration from ADP phosphorylation in mitochondria.	Adenosine Diphosphate	87-90	uncoupling protein 1	Homo sapiens	0-4
27794497-2	2017	We entered this field in 1980 with the isolation of native UCP1 and then reported the amino acid sequence structure discovering a strong homology to the ADP/ATP carrier.	Adenosine Diphosphate	153-156	uncoupling protein 1	Homo sapiens	59-63
27794497-2	2017	We entered this field in 1980 with the isolation of native UCP1 and then reported the amino acid sequence structure discovering a strong homology to the ADP/ATP carrier.	Adenosine Triphosphate	157-160	uncoupling protein 1	Homo sapiens	59-63
27984203-0	2017	UCP1: A transporter for H+ and fatty acid anions.	Fatty Acids	31-41	uncoupling protein 1	Homo sapiens	0-4
27984203-3	2017	Classic biochemical studies revealed the general principle of adaptive thermogenesis: in the presence of long-chain fatty acids (FA), UCP1 increases the permeability of the inner mitochondrial membrane for H+, which makes brown fat mitochondria produce heat rather than ATP.	long-chain fatty acids	105-127	uncoupling protein 1	Homo sapiens	134-138
27984203-3	2017	Classic biochemical studies revealed the general principle of adaptive thermogenesis: in the presence of long-chain fatty acids (FA), UCP1 increases the permeability of the inner mitochondrial membrane for H+, which makes brown fat mitochondria produce heat rather than ATP.	Adenosine Triphosphate	270-273	uncoupling protein 1	Homo sapiens	134-138
27984203-10	2017	In addition to their transport function, long-chain FA competitively remove tonic inhibition of UCP1 by cytosolic purine nucleotides, thus enabling activation of the thermogenic H+ leak through UCP1 under physiological conditions.	Purine Nucleotides	114-132	uncoupling protein 1	Homo sapiens	96-100
28057583-6	2017	UCP1 has the same structural fold as other mitochondrial carriers and, in contrast to past claims, is a monomer, binding one purine nucleotide and three cardiolipin molecules tightly.	purine	125-131	uncoupling protein 1	Homo sapiens	0-4
28580291-8	2017	In contrast, we found that the marked glucose uptake-ameliorating effect of prolonged beta3-adrenergic treatment was UCP1 dependent.	Glucose	38-45	uncoupling protein 1	Homo sapiens	117-121
27622583-3	2017	Brown adipocytes trough their unique mitochondrial UCP1 protein burn glucose and lipids to perform thermogenesis in order to survive in cold environments.	Glucose	69-76	uncoupling protein 1	Homo sapiens	51-55
27750036-2	2017	We have characterized the human UCP1 (HsUCP1) recombinantly expressed in Saccharomyces cerevisiae and we demonstrate that HsUCP1 is activated by fatty acids and retinoids in a nucleotide sensitive manner just as its rodent orthologs.	Fatty Acids	145-156	uncoupling protein 1	Homo sapiens	32-36
27750036-2	2017	We have characterized the human UCP1 (HsUCP1) recombinantly expressed in Saccharomyces cerevisiae and we demonstrate that HsUCP1 is activated by fatty acids and retinoids in a nucleotide sensitive manner just as its rodent orthologs.	Retinoids	161-170	uncoupling protein 1	Homo sapiens	32-36
28318397-1	2017	OBJECTIVE: beta-Aminoisobutyric acid (BAIBA) has shown to modulate uncoupling protein (UCP)-1 expression, which is mainly expressed in white adipose tissue; however, no studies to date have analyzed its potential effect on the main uncoupling protein of skeletal muscle, UCP-3.	3-aminoisobutyric acid	11-36	uncoupling protein 1	Homo sapiens	67-93
28117414-0	2017	Piperine regulates UCP1 through the AMPK pathway by generating intracellular lactate production in muscle cells.	piperine	0-8	uncoupling protein 1	Homo sapiens	19-23
28620480-0	2017	Reduction of HbA1c levels by fucoxanthin-enriched akamoku oil possibly involves the thrifty allele of uncoupling protein 1 (UCP1): a randomised controlled trial in normal-weight and obese Japanese adults.	fucoxanthin	29-40	uncoupling protein 1	Homo sapiens	102-122
28620480-0	2017	Reduction of HbA1c levels by fucoxanthin-enriched akamoku oil possibly involves the thrifty allele of uncoupling protein 1 (UCP1): a randomised controlled trial in normal-weight and obese Japanese adults.	fucoxanthin	29-40	uncoupling protein 1	Homo sapiens	124-128
28620480-0	2017	Reduction of HbA1c levels by fucoxanthin-enriched akamoku oil possibly involves the thrifty allele of uncoupling protein 1 (UCP1): a randomised controlled trial in normal-weight and obese Japanese adults.	enriched akamoku oil	41-61	uncoupling protein 1	Homo sapiens	102-122
28620480-0	2017	Reduction of HbA1c levels by fucoxanthin-enriched akamoku oil possibly involves the thrifty allele of uncoupling protein 1 (UCP1): a randomised controlled trial in normal-weight and obese Japanese adults.	enriched akamoku oil	41-61	uncoupling protein 1	Homo sapiens	124-128
28620480-10	2017	We conclude that although Fx supplementation does not affect visceral fat areas, it may reduce HbA1c levels in those harbouring the thrifty allele of UCP1-3826A/G.	fucoxanthin	26-28	uncoupling protein 1	Homo sapiens	150-154
28158227-10	2017	Metformin treatment brought about a significant reduction of visceral fat mass compared to controls accompanied by an up-regulation of fat oxidation-related enzyme in the liver, UCP-1 in the brown adipose tissue and UCP-3 in the skeletal muscle.	Metformin	0-9	uncoupling protein 1	Homo sapiens	178-183
27740628-6	2017	Mechanistically, PTHrP activates both PKA/cAMP and Akt/Foxo pathways for Ucp1 expression in WAT.	Cyclic AMP	42-46	uncoupling protein 1	Homo sapiens	73-77
28117414-0	2017	Piperine regulates UCP1 through the AMPK pathway by generating intracellular lactate production in muscle cells.	Lactic Acid	77-84	uncoupling protein 1	Homo sapiens	19-23
28117414-6	2017	Increased level of lactate resulted in increased expression of mitochondrial uncoupling protein 1 (UCP1), which regulates energy expenditure, thermogenesis, and fat browning.	Lactic Acid	19-26	uncoupling protein 1	Homo sapiens	99-103
28117414-7	2017	Knock-down of AMPK blocked piperine-induced UCP1 up-regulation, demonstrating the required role of AMPK in this effect.	piperine	27-35	uncoupling protein 1	Homo sapiens	44-48
28117414-8	2017	Taken together, these results suggest that piperine leads to benign metabolic effects by activating the AMPK-p38 MAPK signaling pathway and UCP1 expression by activating intracellular lactate production in skeletal muscle.	piperine	43-51	uncoupling protein 1	Homo sapiens	140-144
27998096-2	2016	The proton transport activity of UCP1 and UCP2 requires activation by fatty acids.	Fatty Acids	70-81	uncoupling protein 1	Homo sapiens	33-37
29743989-7	2017	We applied this method for a quantitative characterization of the binding mechanism between mitochondrial uncoupling protein 1 (UCP1) and its inhibitor adenosine triphosphate (ATP).	Adenosine Triphosphate	152-174	uncoupling protein 1	Homo sapiens	128-132
29743989-7	2017	We applied this method for a quantitative characterization of the binding mechanism between mitochondrial uncoupling protein 1 (UCP1) and its inhibitor adenosine triphosphate (ATP).	Adenosine Triphosphate	176-179	uncoupling protein 1	Homo sapiens	128-132
27686967-0	2016	Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.	Sirolimus	0-9	uncoupling protein 1	Homo sapiens	67-87
27974179-0	2016	Browning of White Adipose Tissue with Roscovitine Induces a Distinct Population of UCP1+ Adipocytes.	Roscovitine	38-49	uncoupling protein 1	Homo sapiens	83-87
27974179-6	2016	Here, we report that roscovitine, a CDK inhibitor, prevents S273 phosphorylation and promotes formation of UCP1+ (brite) adipocytes in WAT.	Roscovitine	21-32	uncoupling protein 1	Homo sapiens	107-111
27686967-10	2016	Rapamycin also inhibited norepinephrine (NE)-induced lipolysis, the expression of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) and uncoupling protein (UCP)-1 in brown adipocytes.	Sirolimus	0-9	uncoupling protein 1	Homo sapiens	167-193
27091404-7	2016	Proton transport by UCP1 is activated by fatty acids and this ensures thermogenesis.	Fatty Acids	41-52	uncoupling protein 1	Homo sapiens	20-24
27933825-11	2016	NIR-triggered nanocomposites of UCP@SiO2:MB-NRs were significantly confirmed by improving ROS generation and further modifying folic acid (FA) to develop an active component targeting OECM-1 oral cancer cells.	Reactive Oxygen Species	90-93	uncoupling protein 1	Homo sapiens	32-35
27898069-2	2016	We observed that clozapine but not six other antipsychotic drugs reprogrammed the gene expression pattern of differentiating human adipocytes ex vivo, leading to an elevated expression of the browning marker gene UCP1, more and smaller lipid droplets and more mitochondrial DNA than in the untreated white adipocytes.	Clozapine	17-26	uncoupling protein 1	Homo sapiens	213-217
26916829-1	2016	It has been shown that oleuropein, a phenolic compound in the fruit and leaves of the olive tree (Olea europaea) induces mammalian uncoupling protein 1 (UCP1) expression via an increased secretion of noradrenaline and adrenaline.	Norepinephrine	200-213	uncoupling protein 1	Homo sapiens	153-157
27637001-9	2016	In parallel, EPA induced the expression of genes that typify beige adipocytes such as fat determination factor PR domain containing 16, uncoupling protein 1 and cell death-inducing DFFA-like effector A, T-Box protein 1 and CD137.	Eicosapentaenoic Acid	13-16	uncoupling protein 1	Homo sapiens	136-156
27933825-11	2016	NIR-triggered nanocomposites of UCP@SiO2:MB-NRs were significantly confirmed by improving ROS generation and further modifying folic acid (FA) to develop an active component targeting OECM-1 oral cancer cells.	Folic Acid	127-137	uncoupling protein 1	Homo sapiens	32-35
27933825-12	2016	Consequently, UCP@SiO2:MB-NRs-FA could highly produce ROS and undergo efficient PDT in vitro and in vivo.	Reactive Oxygen Species	54-57	uncoupling protein 1	Homo sapiens	14-17
27651074-2	2016	UCP was firstly transferred to aqueous phase using cationic surfactant cetyl trimethyl ammonium bromide (CTAB) via hydrophobic interaction without removing the existing oleic acid (OA).	Cetrimonium	71-103	uncoupling protein 1	Homo sapiens	0-3
27651074-2	2016	UCP was firstly transferred to aqueous phase using cationic surfactant cetyl trimethyl ammonium bromide (CTAB) via hydrophobic interaction without removing the existing oleic acid (OA).	Cetrimonium	105-109	uncoupling protein 1	Homo sapiens	0-3
27651074-2	2016	UCP was firstly transferred to aqueous phase using cationic surfactant cetyl trimethyl ammonium bromide (CTAB) via hydrophobic interaction without removing the existing oleic acid (OA).	Oleic Acid	169-179	uncoupling protein 1	Homo sapiens	0-3
27651074-2	2016	UCP was firstly transferred to aqueous phase using cationic surfactant cetyl trimethyl ammonium bromide (CTAB) via hydrophobic interaction without removing the existing oleic acid (OA).	Oleic Acid	181-183	uncoupling protein 1	Homo sapiens	0-3
27651074-4	2016	The final carboxyl functionalized UCP@CTAB@PSS@PAH@PAA was then conjugated with monoclonal antibody1 (AB1) of procalcitonin (PCT), resulting in successful detection of PCT antigens based on the immunochromatographic assay (ICA).	polyallylamine	47-50	uncoupling protein 1	Homo sapiens	34-42
27651074-4	2016	The final carboxyl functionalized UCP@CTAB@PSS@PAH@PAA was then conjugated with monoclonal antibody1 (AB1) of procalcitonin (PCT), resulting in successful detection of PCT antigens based on the immunochromatographic assay (ICA).	carbopol 940	51-54	uncoupling protein 1	Homo sapiens	34-42
27561621-2	2016	Brown adipocytes are responsible for performing non-shivering thermogenesis, which is exclusively mediated by uncoupling protein (UCP) -1 (a protein found in the inner mitochondrial membrane), the hallmark of BAT, responsible for the uncoupling of the proton leakage from the ATP production, therefore, generating heat (i.e. thermogenesis).	Adenosine Triphosphate	276-279	uncoupling protein 1	Homo sapiens	110-137
27218607-6	2016	SFN enhanced uncoupling protein 1 expression, a marker for brown adipocyte, leading to the decrease in cellular ATP.	Adenosine Triphosphate	112-115	uncoupling protein 1	Homo sapiens	13-33
27281219-0	2016	Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.	ros	27-30	uncoupling protein 1	Homo sapiens	92-96
27685940-0	2016	E2-EPF UCP Possesses E3 Ubiquitin Ligase Activity via Its Cysteine 118 Residue.	Cysteine	58-66	uncoupling protein 1	Homo sapiens	7-10
27685940-1	2016	Here, we show that E2-EPF ubiquitin carrier protein (UCP) elongated E3-independent polyubiquitin chains on the lysine residues of von Hippel-Lindau protein (pVHL) and its own lysine residues both in vitro and in vivo.	Lysine	111-117	uncoupling protein 1	Homo sapiens	53-56
27685940-1	2016	Here, we show that E2-EPF ubiquitin carrier protein (UCP) elongated E3-independent polyubiquitin chains on the lysine residues of von Hippel-Lindau protein (pVHL) and its own lysine residues both in vitro and in vivo.	Lysine	175-181	uncoupling protein 1	Homo sapiens	53-56
27685940-4	2016	The polyubiquitin chains appeared on the N-terminus of UCP in vivo, which indicated that the N-terminus of UCP contains target lysines for polyubiquitination.	Lysine	127-134	uncoupling protein 1	Homo sapiens	55-58
27685940-4	2016	The polyubiquitin chains appeared on the N-terminus of UCP in vivo, which indicated that the N-terminus of UCP contains target lysines for polyubiquitination.	Lysine	127-134	uncoupling protein 1	Homo sapiens	107-110
27685940-6	2016	A UCP mutant in which Cys118 was changed to alanine (UCPC118A) did not form a polyubiquitin chain but did strongly accumulate mono- and di-ubiquitin via auto-ubiquitination.	mono- and di-ubiquitin	126-148	uncoupling protein 1	Homo sapiens	2-5
27685940-8	2016	The mechanism of the polyubiquitin chain reaction of UCP may involve the transfer of ubiquitin from Cys95 to Cys118 by trans-thiolation, with polyubiquitin chains forming at Cys118 by reversible thioester bonding.	Cy5-benzyl thioester	195-204	uncoupling protein 1	Homo sapiens	53-56
27165993-8	2016	Significant negative correlations were found between UCP1 and total lipids, triglycerides, VLDLs, Total-Chol, and LDL values.	Triglycerides	76-89	uncoupling protein 1	Homo sapiens	53-57
27165993-8	2016	Significant negative correlations were found between UCP1 and total lipids, triglycerides, VLDLs, Total-Chol, and LDL values.	chol	104-108	uncoupling protein 1	Homo sapiens	53-57
27133810-5	2016	Increased expression of UCP-1 and other brown fat-specific markers was possibly mediated by chrysin-induced activation of AMPK based on the fact that inhibition of AMPK by dorsomorphin abolished expression of PR domain-containing 16, UCP-1, and PGC-1alpha while the activator 5-aminoimidazole-4-carboxamide ribonucleotide elevated expression of these brown marker proteins.	dorsomorphin	172-184	uncoupling protein 1	Homo sapiens	24-29
27133810-5	2016	Increased expression of UCP-1 and other brown fat-specific markers was possibly mediated by chrysin-induced activation of AMPK based on the fact that inhibition of AMPK by dorsomorphin abolished expression of PR domain-containing 16, UCP-1, and PGC-1alpha while the activator 5-aminoimidazole-4-carboxamide ribonucleotide elevated expression of these brown marker proteins.	dorsomorphin	172-184	uncoupling protein 1	Homo sapiens	234-239
27133810-5	2016	Increased expression of UCP-1 and other brown fat-specific markers was possibly mediated by chrysin-induced activation of AMPK based on the fact that inhibition of AMPK by dorsomorphin abolished expression of PR domain-containing 16, UCP-1, and PGC-1alpha while the activator 5-aminoimidazole-4-carboxamide ribonucleotide elevated expression of these brown marker proteins.	AICA ribonucleotide	276-321	uncoupling protein 1	Homo sapiens	24-29
27320865-5	2016	Furthermore, we confirmed that agrimol B dramatically inhibited 3T3-L1 adipocyte differentiation by reducing PPARgamma, C/EBPalpha, FAS, UCP-1, and apoE expression.	agrimol B	31-40	uncoupling protein 1	Homo sapiens	137-142
27045997-8	2016	Combinations of approaches to increase intracellular NAA levels showed additive effects on lipolysis and gene repression, nearly abolishing the expression of Ucp1, Cidea, Prdm16, and Ppara.	N-acetylaspartate	53-56	uncoupling protein 1	Homo sapiens	158-162
27508873-6	2016	Human BAT was sensitive to the purine nucleotide GDP, providing the first direct evidence that human BAT mitochondria have thermogenically functional UCP1.	purine	31-37	uncoupling protein 1	Homo sapiens	150-154
27508873-6	2016	Human BAT was sensitive to the purine nucleotide GDP, providing the first direct evidence that human BAT mitochondria have thermogenically functional UCP1.	Guanosine Diphosphate	49-52	uncoupling protein 1	Homo sapiens	150-154
27372851-4	2016	HYPOTHESIS: Recent evidence support a role of l-menthol cooling, mediated by TRPM8 receptor, on UCP1-dependent thermogenesis and BAT-like activity in classical WAT depots along with the recruitment of BAT at specific anatomical sites.	Menthol	46-55	uncoupling protein 1	Homo sapiens	96-100
27372851-7	2016	However, its role in l-menthol-induced UCP1-dependent thermogenic activity in BAT and WAT remains undetermined.	Menthol	21-30	uncoupling protein 1	Homo sapiens	39-43
26041126-0	2016	Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondria.	perfluorinated fatty acids	20-46	uncoupling protein 1	Homo sapiens	65-85
26041126-2	2016	The uncoupling protein 1 (UCP1) in brown adipose tissue is physiologically (re)activated by fatty acids, including octanoate.	Fatty Acids	92-103	uncoupling protein 1	Homo sapiens	4-24
26041126-2	2016	The uncoupling protein 1 (UCP1) in brown adipose tissue is physiologically (re)activated by fatty acids, including octanoate.	Fatty Acids	92-103	uncoupling protein 1	Homo sapiens	26-30
26041126-2	2016	The uncoupling protein 1 (UCP1) in brown adipose tissue is physiologically (re)activated by fatty acids, including octanoate.	octanoic acid	115-124	uncoupling protein 1	Homo sapiens	4-24
26041126-2	2016	The uncoupling protein 1 (UCP1) in brown adipose tissue is physiologically (re)activated by fatty acids, including octanoate.	octanoic acid	115-124	uncoupling protein 1	Homo sapiens	26-30
26041126-10	2016	Thus, metabolic effects of perfluorinated fatty acids could include direct brown adipose tissue (UCP1) activation.	perfluorinated fatty acids	27-53	uncoupling protein 1	Homo sapiens	97-101
26041126-12	2016	However, a possibility to utilize PFOA-/PFOS-like substances for activating UCP1 therapeutically in obesity-prone humans may also be envisaged.	perfluorooctanoic acid	34-38	uncoupling protein 1	Homo sapiens	76-80
26041126-12	2016	However, a possibility to utilize PFOA-/PFOS-like substances for activating UCP1 therapeutically in obesity-prone humans may also be envisaged.	perfluorooctane sulfonic acid	40-44	uncoupling protein 1	Homo sapiens	76-80
27124181-11	2016	Moreover, PGE2 induced expression of brown markers (UCP1 and PRDM16) in WAT and adipocytes, but not in pre-adipocytes, suggesting that PGE2 might induce the trans-differentiation of adipocytes towards beige/brite cells.	Dinoprostone	10-14	uncoupling protein 1	Homo sapiens	52-56
27124181-11	2016	Moreover, PGE2 induced expression of brown markers (UCP1 and PRDM16) in WAT and adipocytes, but not in pre-adipocytes, suggesting that PGE2 might induce the trans-differentiation of adipocytes towards beige/brite cells.	Dinoprostone	135-139	uncoupling protein 1	Homo sapiens	52-56
27027295-0	2016	Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.	Reactive Oxygen Species	14-17	uncoupling protein 1	Homo sapiens	79-83
27027295-4	2016	Remarkably, this process supports in vivo thermogenesis, as pharmacological depletion of mitochondrial ROS results in hypothermia upon cold exposure, and inhibits UCP1-dependent increases in whole-body energy expenditure.	Reactive Oxygen Species	103-106	uncoupling protein 1	Homo sapiens	163-167
27027295-7	2016	These studies identify mitochondrial ROS induction in brown adipose tissue as a mechanism that supports UCP1-dependent thermogenesis and whole-body energy expenditure, which opens the way to improved therapeutic strategies for combating metabolic disorders.	Reactive Oxygen Species	37-40	uncoupling protein 1	Homo sapiens	104-108
27529086-3	2016	Benefiting from the enhanced 808 nm-excited UCL intensity of the multilayer UCNPs, the unique photothermal properties of CuS and the pH-responsive drug release capacity of the PAA shell, such a nanoplatform design of UCNPs-CuS@PAA (labeled UCP) offers a new route to achieve 808 nm-excited UCL imaging guided chemo/photothermal combination therapy.	carbopol 940	176-179	uncoupling protein 1	Homo sapiens	240-243
27529086-3	2016	Benefiting from the enhanced 808 nm-excited UCL intensity of the multilayer UCNPs, the unique photothermal properties of CuS and the pH-responsive drug release capacity of the PAA shell, such a nanoplatform design of UCNPs-CuS@PAA (labeled UCP) offers a new route to achieve 808 nm-excited UCL imaging guided chemo/photothermal combination therapy.	cupric sulfide	223-226	uncoupling protein 1	Homo sapiens	240-243
27411014-6	2016	In vitro, glucocorticoids increased isoprenaline-stimulated respiration and UCP-1 in human primary brown adipocytes, but substantially decreased isoprenaline-stimulated respiration and UCP-1 in primary murine brown and beige adipocytes.	Isoproterenol	36-48	uncoupling protein 1	Homo sapiens	76-81
27411014-6	2016	In vitro, glucocorticoids increased isoprenaline-stimulated respiration and UCP-1 in human primary brown adipocytes, but substantially decreased isoprenaline-stimulated respiration and UCP-1 in primary murine brown and beige adipocytes.	Isoproterenol	145-157	uncoupling protein 1	Homo sapiens	185-190
27656399-8	2016	Injections of an miR-125b-5p mimic and LNA inhibitor directly into WAT inhibited and increased beta3-adrenoceptor-mediated induction of UCP1, respectively, and mitochondrial brite adipocyte marker expression and mitochondriogenesis.	mir-125b-5p	17-28	uncoupling protein 1	Homo sapiens	136-140
27071835-6	2016	Increased expression of PRDM16, UCP1, C/EBPbeta, and other brown fat-specific markers by limonene was possibly mediated by activation of beta3-adnergenic receptor (beta3-AR), as inhibition of beta3-AR inhibited up-regulation of brown fat-specific markers.	Limonene	89-97	uncoupling protein 1	Homo sapiens	32-36
26990063-4	2016	Our results show that acetate up-regulates adipocyte protein 2, peroxisomal proliferator-activated receptor-gamma coactivator-1alpha, and uncoupling protein-1 expression and affects the morphological changes of brown adipocytes during adipogenesis.	Acetates	22-29	uncoupling protein 1	Homo sapiens	138-158
26293504-2	2015	One promising approach has been the expansion of brown adipose tissues that express uncoupling protein (UCP) 1 and thus can uncouple mitochondrial respiration from ATP synthesis.	Adenosine Triphosphate	164-167	uncoupling protein 1	Homo sapiens	84-110
26855404-6	2016	Brown adipose tissue can have a significant impact on energy balance and glucose homeostasis through the action of uncoupling protein 1, dissipating chemical energy as heat following neuroendocrine stimulation.	Glucose	73-80	uncoupling protein 1	Homo sapiens	115-135
26775637-5	2016	Herein, we show that cPGI2 generates via its cognate cell-surface receptor IP-R, a cyclic AMP-signaling pathway involving PKA activity which in turn induces the expression of UCP1.	Cyclic AMP	83-93	uncoupling protein 1	Homo sapiens	175-179
26959981-0	2016	UCP1 and UCP3 Expression Is Associated with Lipid and Carbohydrate Oxidation and Body Composition.	Carbohydrates	54-66	uncoupling protein 1	Homo sapiens	0-4
26959981-12	2016	Multiple linear regression analysis showed that the UCP1 and UCP3 genes contributed to lipid and carbohydrate oxidation.	Carbohydrates	97-109	uncoupling protein 1	Homo sapiens	52-56
26959981-14	2016	CONCLUSIONS: UCP1 and UCP3 expression is associated with lipid and carbohydrate oxidation in patients submitted to bariatric surgery.	Carbohydrates	67-79	uncoupling protein 1	Homo sapiens	13-17
26808348-1	2016	Uncoupling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupling electron transport from ATP production.	Adenosine Triphosphate	135-138	uncoupling protein 1	Homo sapiens	0-26
28105413-2	2016	Through ubiquitous expression of uncoupling protein 1 (Ucp1) on the mitochondrial inner membrane, BAT displays uncoupling of fuel combustion and ATP production in order to dissipate energy as heat.	Adenosine Triphosphate	145-148	uncoupling protein 1	Homo sapiens	33-53
28105413-2	2016	Through ubiquitous expression of uncoupling protein 1 (Ucp1) on the mitochondrial inner membrane, BAT displays uncoupling of fuel combustion and ATP production in order to dissipate energy as heat.	Adenosine Triphosphate	145-148	uncoupling protein 1	Homo sapiens	55-59
26456563-6	2016	Increased expression of UCP1 and other brown adipocyte-specific markers was possibly mediated by curcumin-induced activation of AMP-activated protein kinase (AMPK) based on the fact that inhibition of AMPK by dorsomorphin abolished expression of PRDM16, UCP1 and peroxisome proliferator-activated receptor gamma co-activator 1-alpha while the activator 5-Aminoimidazole-4-carboxamide ribonucleotide elevated expression of these brown marker proteins.	Curcumin	97-105	uncoupling protein 1	Homo sapiens	24-28
26456563-6	2016	Increased expression of UCP1 and other brown adipocyte-specific markers was possibly mediated by curcumin-induced activation of AMP-activated protein kinase (AMPK) based on the fact that inhibition of AMPK by dorsomorphin abolished expression of PRDM16, UCP1 and peroxisome proliferator-activated receptor gamma co-activator 1-alpha while the activator 5-Aminoimidazole-4-carboxamide ribonucleotide elevated expression of these brown marker proteins.	Curcumin	97-105	uncoupling protein 1	Homo sapiens	254-258
26456563-6	2016	Increased expression of UCP1 and other brown adipocyte-specific markers was possibly mediated by curcumin-induced activation of AMP-activated protein kinase (AMPK) based on the fact that inhibition of AMPK by dorsomorphin abolished expression of PRDM16, UCP1 and peroxisome proliferator-activated receptor gamma co-activator 1-alpha while the activator 5-Aminoimidazole-4-carboxamide ribonucleotide elevated expression of these brown marker proteins.	dorsomorphin	209-221	uncoupling protein 1	Homo sapiens	24-28
26456563-6	2016	Increased expression of UCP1 and other brown adipocyte-specific markers was possibly mediated by curcumin-induced activation of AMP-activated protein kinase (AMPK) based on the fact that inhibition of AMPK by dorsomorphin abolished expression of PRDM16, UCP1 and peroxisome proliferator-activated receptor gamma co-activator 1-alpha while the activator 5-Aminoimidazole-4-carboxamide ribonucleotide elevated expression of these brown marker proteins.	dorsomorphin	209-221	uncoupling protein 1	Homo sapiens	254-258
26456563-6	2016	Increased expression of UCP1 and other brown adipocyte-specific markers was possibly mediated by curcumin-induced activation of AMP-activated protein kinase (AMPK) based on the fact that inhibition of AMPK by dorsomorphin abolished expression of PRDM16, UCP1 and peroxisome proliferator-activated receptor gamma co-activator 1-alpha while the activator 5-Aminoimidazole-4-carboxamide ribonucleotide elevated expression of these brown marker proteins.	AICA ribonucleotide	353-398	uncoupling protein 1	Homo sapiens	24-28
27642497-5	2016	UCP activation may affect cytochrome c and proapoptotic protein release from mitochondria by reducing ROS generation and apoptotic cell death.	Reactive Oxygen Species	102-105	uncoupling protein 1	Homo sapiens	0-3
26293504-5	2015	We adapted the biophysical properties of hyaluronic acid-based hydrogels to support the differentiation of white adipose tissue-derived multipotent stem cells (ADMSCs) into lipid-accumulating, UCP1-expressing beige adipose tissue.	Hyaluronic Acid	41-56	uncoupling protein 1	Homo sapiens	193-197
26370079-9	2015	Consistently, TLR4 activation by LPS abolished cAMP-induced up-regulation of uncoupling protein 1 (UCP1) in primary human adipocytes, which was reversed by silencing of C/EBP homologous protein (CHOP).	Cyclic AMP	47-51	uncoupling protein 1	Homo sapiens	77-97
26370079-9	2015	Consistently, TLR4 activation by LPS abolished cAMP-induced up-regulation of uncoupling protein 1 (UCP1) in primary human adipocytes, which was reversed by silencing of C/EBP homologous protein (CHOP).	Cyclic AMP	47-51	uncoupling protein 1	Homo sapiens	99-103
26322018-2	2015	In response to cold, both classical brown fat and the newly identified "beige" or "brite" cells are activated by beta-adrenergic signaling and catabolize stored lipids and carbohydrates to produce heat via UCP1.	Carbohydrates	172-185	uncoupling protein 1	Homo sapiens	206-210
26539163-3	2015	Expansion and/or stimulation of uncoupling protein-1 (UCP1)-positive adipose tissues have repeatedly demonstrated physiologically beneficial reductions in circulating glucose and lipids.	Glucose	167-174	uncoupling protein 1	Homo sapiens	32-58
26539163-6	2015	Recent developments in bioengineering, including novel hyaluronic acid-based hydrogels, have enabled non-immunogenic, functional tissue allografts that can be used to generate large quantities of UCP1-positive adipose tissue.	Hyaluronic Acid	55-70	uncoupling protein 1	Homo sapiens	196-200
26388708-4	2015	CLA supplementation also could increase the lipolysis and reduce the accumulation of fatty acids on the adipose tissue; the putative mechanisms involved may be its action in reducing the lipase lipoprotein activity and to increase the carnitine-palmitoil-transferase-1 (CAT-1) activity, its interaction with PPARgamma, and to raise the expression of UCP-1.	Linoleic Acids, Conjugated	0-3	uncoupling protein 1	Homo sapiens	350-355
25910810-5	2015	Under nonphosphorylating and phosphorylating conditions, UCP activity was significantly higher in mitochondria isolated from high glucose-treated cells.	Glucose	130-137	uncoupling protein 1	Homo sapiens	57-60
26179979-1	2015	OBJECTIVE: Brown adipose tissue (BAT) can generate heat by burning fatty acids, a process mediated by uncoupling protein 1 (UCP1).	Fatty Acids	67-78	uncoupling protein 1	Homo sapiens	102-122
26179979-1	2015	OBJECTIVE: Brown adipose tissue (BAT) can generate heat by burning fatty acids, a process mediated by uncoupling protein 1 (UCP1).	Fatty Acids	67-78	uncoupling protein 1	Homo sapiens	124-128
26451286-4	2015	While the gene expression profile and basal bioenergetics of 3T3-L1 adipocytes was typical of white adipocytes, they responded acutely to catecholamines by increasing oxygen consumption in an UCP1-dependent manner, and by increasing the expression of genes enriched in brown but not beige adipocytes.	Catecholamines	138-152	uncoupling protein 1	Homo sapiens	192-196
26038550-1	2015	Uncoupling protein 1 (UCP1) catalyzes fatty acid-activated, purine nucleotide-sensitive proton leak across the mitochondrial inner membrane of brown adipose tissue to produce heat, and could help combat obesity and metabolic disease in humans.	Fatty Acids	38-48	uncoupling protein 1	Homo sapiens	0-26
26038550-1	2015	Uncoupling protein 1 (UCP1) catalyzes fatty acid-activated, purine nucleotide-sensitive proton leak across the mitochondrial inner membrane of brown adipose tissue to produce heat, and could help combat obesity and metabolic disease in humans.	Purine Nucleotides	60-77	uncoupling protein 1	Homo sapiens	0-26
26038550-4	2015	Assessment of purified preparations by TLC reveal that UCP1 retains tightly bound cardiolipin, with a lipid phosphorus content equating to three molecules per protein, like the ADP/ATP carrier.	lipid phosphorus	102-118	uncoupling protein 1	Homo sapiens	55-59
25761413-9	2015	Resveratrol also induced beige adipogenesis in vivo along with the appearance of multiocular adipocytes, increased UCP1 expression and enhanced fatty acid oxidation.	Resveratrol	0-11	uncoupling protein 1	Homo sapiens	115-119
25928572-8	2015	However, subjects carrying the beta3-AR TrpTrp genotype and UCP1 AG genotype had higher TG levels than those carrying the Arg allele and AA genotype, respectively (P&lt;0.05), while controls carrying the beta3-AR Arg allele had significantly higher TC and apo AII concentrations than those carrying the TrpTrp genotype (P&lt;0.05).	Triglycerides	88-90	uncoupling protein 1	Homo sapiens	60-64
25928572-11	2015	CONCLUSIONS: The present study provides evidence that the beta3-AR Trp64Arg and UCP1 -3826 A&gt;G polymorphisms are associated with TG levels in overweight/obese Chinese subjects and that the two polymorphisms are also associated with certain lipid and apolipoprotein variations, depending on BMI.	Triglycerides	132-134	uncoupling protein 1	Homo sapiens	80-84
25433289-4	2015	In contrast, the thermogenic function of BAT allows high consumption of fatty acids because of the activity of uncoupling protein 1 in the internal mitochondrial membrane.	Fatty Acids	72-83	uncoupling protein 1	Homo sapiens	111-131
25871295-6	2015	Nutrigenomic studies reveal that fucoxanthin induces UCP1 in abdominal WAT mitochondria, leading to the oxidation of fatty acids and heat production in WAT.	fucoxanthin	33-44	uncoupling protein 1	Homo sapiens	53-57
25871295-6	2015	Nutrigenomic studies reveal that fucoxanthin induces UCP1 in abdominal WAT mitochondria, leading to the oxidation of fatty acids and heat production in WAT.	Fatty Acids	117-128	uncoupling protein 1	Homo sapiens	53-57
25789405-8	2015	In addition, it was suggested that the positively charged residues on TM2 domains of UCPs 1 and 2 were important for their chloride transport activity.	Chlorides	123-131	uncoupling protein 1	Homo sapiens	85-97
25385872-8	2015	During differentiation, dexamethasone (at 0.1, 1, and 10 muM) stimulated the expression of UCP1, CIDEA, and PPARGC1A in a concentration-dependent manner and enhanced by fourfold to sixfold the OCR of brown adipocytes.	Dexamethasone	24-37	uncoupling protein 1	Homo sapiens	91-95
25557764-8	2015	Thus an increase in Sirt4, Nrf2, Tfam, UCP1, eNOS, HO1 and STAT3 genes could profoundly affect mitochondrial function, cholesterol homeostasis, and fatty acid oxidation, suggesting that ASA could be beneficial beyond simply its ability to inhibit cyclooxygenase.	Fatty Acids	148-158	uncoupling protein 1	Homo sapiens	39-43
25557764-8	2015	Thus an increase in Sirt4, Nrf2, Tfam, UCP1, eNOS, HO1 and STAT3 genes could profoundly affect mitochondrial function, cholesterol homeostasis, and fatty acid oxidation, suggesting that ASA could be beneficial beyond simply its ability to inhibit cyclooxygenase.	Aspirin	186-189	uncoupling protein 1	Homo sapiens	39-43
25651169-3	2015	(2014) find that peripheral serotonin controls thermogenesis in adipose tissue by modulating beta-adrenergic stimulation of UCP-1, thereby affecting glucose homeostasis and weight gain.	Serotonin	28-37	uncoupling protein 1	Homo sapiens	124-129
25385872-9	2015	Isoprenaline (100 nM) significantly increased (P&lt;0.05) expression of UCP1 and OCR of brown adipocytes.	Isoproterenol	0-12	uncoupling protein 1	Homo sapiens	72-76
26749900-3	2015	Brown adipose cells produce heat by means of uncoupler protein 1 (UCP1) from fatty acids and sugar.	Fatty Acids	77-88	uncoupling protein 1	Homo sapiens	66-70
26012107-5	2015	In realization of calorigenic effect of catecholamines during long-term cold exposures it is participated following signaling pathway: catecholamines --&gt; beta-adrenergic receptors (AR) --&gt; adenylyl cyclase --&gt; cAMP --&gt; protein kinase A --&gt; p38 kinase --&gt; transcription factors --&gt; enhancement of UCP expression.	Catecholamines	40-54	uncoupling protein 1	Homo sapiens	317-320
26012107-5	2015	In realization of calorigenic effect of catecholamines during long-term cold exposures it is participated following signaling pathway: catecholamines --&gt; beta-adrenergic receptors (AR) --&gt; adenylyl cyclase --&gt; cAMP --&gt; protein kinase A --&gt; p38 kinase --&gt; transcription factors --&gt; enhancement of UCP expression.	Catecholamines	135-149	uncoupling protein 1	Homo sapiens	317-320
26012107-5	2015	In realization of calorigenic effect of catecholamines during long-term cold exposures it is participated following signaling pathway: catecholamines --&gt; beta-adrenergic receptors (AR) --&gt; adenylyl cyclase --&gt; cAMP --&gt; protein kinase A --&gt; p38 kinase --&gt; transcription factors --&gt; enhancement of UCP expression.	Cyclic AMP	219-223	uncoupling protein 1	Homo sapiens	317-320
26012107-6	2015	At acute cold exposure it was realized catecholamines --&gt; beta-AR --&gt; adenylyl cyclase --&gt; cAMP --&gt; protein kinase A --&gt; hormone sensitive lipase --&gt; free fatty acids --&gt; UCP --&gt; uncoupling oxidative phosphorylation.	Catecholamines	39-53	uncoupling protein 1	Homo sapiens	192-195
26012107-6	2015	At acute cold exposure it was realized catecholamines --&gt; beta-AR --&gt; adenylyl cyclase --&gt; cAMP --&gt; protein kinase A --&gt; hormone sensitive lipase --&gt; free fatty acids --&gt; UCP --&gt; uncoupling oxidative phosphorylation.	Cyclic AMP	100-104	uncoupling protein 1	Homo sapiens	192-195
26749900-3	2015	Brown adipose cells produce heat by means of uncoupler protein 1 (UCP1) from fatty acids and sugar.	Sugars	93-98	uncoupling protein 1	Homo sapiens	66-70
25308493-2	2015	We have demonstrated the conclusive evidence for the presence of UCP1 in thymus mitochondria and we have been able to demonstrate a GDP-sensitive UCP1-dependent proton leak in non-phosphorylating thymus mitochondria.	Guanosine Diphosphate	132-135	uncoupling protein 1	Homo sapiens	146-150
25308493-4	2015	We show how to measure GDP-sensitive UCP1-dependent oxygen consumption in non-phosphorylating thymus mitochondria and we show that increased reactive oxygen species production occurs on addition of GDP to non-phosphorylating thymus mitochondria.	Guanosine Diphosphate	23-26	uncoupling protein 1	Homo sapiens	37-41
25308493-4	2015	We show how to measure GDP-sensitive UCP1-dependent oxygen consumption in non-phosphorylating thymus mitochondria and we show that increased reactive oxygen species production occurs on addition of GDP to non-phosphorylating thymus mitochondria.	Oxygen	52-58	uncoupling protein 1	Homo sapiens	37-41
25308493-4	2015	We show how to measure GDP-sensitive UCP1-dependent oxygen consumption in non-phosphorylating thymus mitochondria and we show that increased reactive oxygen species production occurs on addition of GDP to non-phosphorylating thymus mitochondria.	Reactive Oxygen Species	141-164	uncoupling protein 1	Homo sapiens	37-41
25308493-4	2015	We show how to measure GDP-sensitive UCP1-dependent oxygen consumption in non-phosphorylating thymus mitochondria and we show that increased reactive oxygen species production occurs on addition of GDP to non-phosphorylating thymus mitochondria.	Guanosine Diphosphate	198-201	uncoupling protein 1	Homo sapiens	37-41
25308493-5	2015	We conclude that reactive oxygen species production rate can be used as a surrogate for detecting UCP1 catalyzed proton leak activity in thymus mitochondria.	Reactive Oxygen Species	17-40	uncoupling protein 1	Homo sapiens	98-102
25207999-5	2014	An especially significant finding is the induction by melatonin of white adipose tissue browning, which may be related to its effects against oxidative stress, uncoupling the mitochondrial bioenergetic process by enhancing the expression of uncoupled-protein-1 (UCP-1), which has been related to body weight reduction in experimental animals.	Melatonin	54-63	uncoupling protein 1	Homo sapiens	241-260
25224037-7	2014	These findings led to a model of UCP1 controlling mitochondrial ROS release and, presumably, being controlled by high membrane potential, as proposed in the canonical model of "mild uncoupling".	Reactive Oxygen Species	64-67	uncoupling protein 1	Homo sapiens	33-37
25224037-0	2014	Antioxidant properties of UCP1 are evolutionarily conserved in mammals and buffer mitochondrial reactive oxygen species.	Reactive Oxygen Species	96-119	uncoupling protein 1	Homo sapiens	26-30
25224037-4	2014	We show that the reduction of ROS by UCP1 activity also occurs in BAT mitochondria of the tenrec, suggesting that the antioxidative role of UCP1 is an ancient mammalian trait.	Reactive Oxygen Species	30-33	uncoupling protein 1	Homo sapiens	37-41
25224037-4	2014	We show that the reduction of ROS by UCP1 activity also occurs in BAT mitochondria of the tenrec, suggesting that the antioxidative role of UCP1 is an ancient mammalian trait.	Reactive Oxygen Species	30-33	uncoupling protein 1	Homo sapiens	140-144
25224037-5	2014	Our analysis shows that the quantity of UCP1 displays strong control over mitochondrial hydrogen peroxide release, whereas other factors, such as mild cold, nonshivering thermogenesis, oxidative capacity, and mitochondrial respiration, do not correlate.	Hydrogen Peroxide	88-105	uncoupling protein 1	Homo sapiens	40-44
25207999-5	2014	An especially significant finding is the induction by melatonin of white adipose tissue browning, which may be related to its effects against oxidative stress, uncoupling the mitochondrial bioenergetic process by enhancing the expression of uncoupled-protein-1 (UCP-1), which has been related to body weight reduction in experimental animals.	Melatonin	54-63	uncoupling protein 1	Homo sapiens	262-267
24789919-7	2014	Lactate controls Ucp1 expression independently of hypoxia-inducible factor-1alpha and PPARalpha pathways but requires active PPARgamma signaling.	Lactic Acid	0-7	uncoupling protein 1	Homo sapiens	17-21
24789919-8	2014	We demonstrate that the lactate effect on Ucp1 is mediated by intracellular redox modifications as a result of lactate transport through monocarboxylate transporters.	Lactic Acid	24-31	uncoupling protein 1	Homo sapiens	42-46
24789919-8	2014	We demonstrate that the lactate effect on Ucp1 is mediated by intracellular redox modifications as a result of lactate transport through monocarboxylate transporters.	Lactic Acid	111-118	uncoupling protein 1	Homo sapiens	42-46
25506549-4	2014	Both prostaglandins induce an oscillatory Ca(++) signaling coupled to ERK pathway and trigger a decrease in UCP1 expression and in oxygen consumption without altering mitochondriogenesis.	Prostaglandins	5-19	uncoupling protein 1	Homo sapiens	108-112
25122002-6	2014	UCP1 was clearly detectable in all samples analysed and its abundance was significantly reduced in the IUGR piglets that had received saline compared with controls, but was raised to the same amount as in controls in those IUGR females given leptin.	Sodium Chloride	134-140	uncoupling protein 1	Homo sapiens	0-4
24256707-3	2014	We investigated whether nebivolol is able to induce beta3AR-mediated lipolysis, uncoupling protein 1 (UCP1), and size-reduction in human adipocytes.	Nebivolol	24-33	uncoupling protein 1	Homo sapiens	80-100
24771016-0	2014	Triiodothyronine regulates distribution of thyroid hormone receptors by activating AMP-activated protein kinase in 3T3-L1 adipocytes and induces uncoupling protein-1 expression.	Triiodothyronine	0-16	uncoupling protein 1	Homo sapiens	145-165
24825887-0	2014	Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species.	Reactive Oxygen Species	70-93	uncoupling protein 1	Homo sapiens	18-38
24825887-5	2014	Here, we describe the involvement of Sestrin2 and reactive oxygen species (ROS) in regulation of Ucp1 expression.	Reactive Oxygen Species	50-73	uncoupling protein 1	Homo sapiens	97-101
24825887-5	2014	Here, we describe the involvement of Sestrin2 and reactive oxygen species (ROS) in regulation of Ucp1 expression.	Reactive Oxygen Species	75-78	uncoupling protein 1	Homo sapiens	97-101
24825887-9	2014	Consistently, ROS-suppressing antioxidant chemicals, such as butylated hydroxyanisole and N-acetylcysteine, inhibited cold- or cAMP-induced Ucp1 expression as well.	Reactive Oxygen Species	14-17	uncoupling protein 1	Homo sapiens	140-144
24825887-9	2014	Consistently, ROS-suppressing antioxidant chemicals, such as butylated hydroxyanisole and N-acetylcysteine, inhibited cold- or cAMP-induced Ucp1 expression as well.	Butylated Hydroxyanisole	61-85	uncoupling protein 1	Homo sapiens	140-144
24825887-9	2014	Consistently, ROS-suppressing antioxidant chemicals, such as butylated hydroxyanisole and N-acetylcysteine, inhibited cold- or cAMP-induced Ucp1 expression as well.	Acetylcysteine	90-106	uncoupling protein 1	Homo sapiens	140-144
24825887-9	2014	Consistently, ROS-suppressing antioxidant chemicals, such as butylated hydroxyanisole and N-acetylcysteine, inhibited cold- or cAMP-induced Ucp1 expression as well.	Cyclic AMP	127-131	uncoupling protein 1	Homo sapiens	140-144
24825887-10	2014	p38 MAPK, a signaling mediator required for cAMP-induced Ucp1 expression, was inhibited by either Sestrin2 overexpression or antioxidant treatments.	Cyclic AMP	44-48	uncoupling protein 1	Homo sapiens	57-61
24825887-11	2014	Taken together, these results suggest that Sestrin2 and antioxidants inhibit Ucp1 expression through suppressing ROS-mediated p38 MAPK activation, implying a critical role of ROS in proper BAT metabolism.	Reactive Oxygen Species	113-116	uncoupling protein 1	Homo sapiens	77-81
24825887-11	2014	Taken together, these results suggest that Sestrin2 and antioxidants inhibit Ucp1 expression through suppressing ROS-mediated p38 MAPK activation, implying a critical role of ROS in proper BAT metabolism.	Reactive Oxygen Species	175-178	uncoupling protein 1	Homo sapiens	77-81
24627558-7	2014	Cellular bioenergetics measurements confirm that attenuation of UCP-1 expression by PRR activation is accompanied by suppression of both basal and isoproterenol-stimulated oxygen consumption rates and isoproterenol-induced uncoupled respiration from proton leak; however, maximal respiration and ATP-coupled respiration are not changed.	Isoproterenol	147-160	uncoupling protein 1	Homo sapiens	64-69
24627558-7	2014	Cellular bioenergetics measurements confirm that attenuation of UCP-1 expression by PRR activation is accompanied by suppression of both basal and isoproterenol-stimulated oxygen consumption rates and isoproterenol-induced uncoupled respiration from proton leak; however, maximal respiration and ATP-coupled respiration are not changed.	Oxygen	172-178	uncoupling protein 1	Homo sapiens	64-69
24627558-7	2014	Cellular bioenergetics measurements confirm that attenuation of UCP-1 expression by PRR activation is accompanied by suppression of both basal and isoproterenol-stimulated oxygen consumption rates and isoproterenol-induced uncoupled respiration from proton leak; however, maximal respiration and ATP-coupled respiration are not changed.	Isoproterenol	201-214	uncoupling protein 1	Homo sapiens	64-69
24627558-7	2014	Cellular bioenergetics measurements confirm that attenuation of UCP-1 expression by PRR activation is accompanied by suppression of both basal and isoproterenol-stimulated oxygen consumption rates and isoproterenol-induced uncoupled respiration from proton leak; however, maximal respiration and ATP-coupled respiration are not changed.	Adenosine Triphosphate	296-299	uncoupling protein 1	Homo sapiens	64-69
24256707-0	2014	Nebivolol induces, via beta3 adrenergic receptor, lipolysis, uncoupling protein 1, and reduction of lipid droplet size in human adipocytes.	Nebivolol	0-9	uncoupling protein 1	Homo sapiens	61-81
25127353-4	2014	UCP-mediated proton currents require fatty acids (FAs) and are blocked by nucleotides, but the molecular basis of these processes is unknown.	Fatty Acids	37-48	uncoupling protein 1	Homo sapiens	0-3
25127353-4	2014	UCP-mediated proton currents require fatty acids (FAs) and are blocked by nucleotides, but the molecular basis of these processes is unknown.	Fatty Acids	50-53	uncoupling protein 1	Homo sapiens	0-3
24342393-4	2014	In the present study we demonstrated that human white adipocytes express the cold-sensing receptor TRPM8 which activation by menthol and icilin induced a rise in [Ca2+](i) and UCP1 expression, increased mitochondrial membrane potential, glucose uptake and heat production.	Menthol	125-132	uncoupling protein 1	Homo sapiens	176-180
24342393-4	2014	In the present study we demonstrated that human white adipocytes express the cold-sensing receptor TRPM8 which activation by menthol and icilin induced a rise in [Ca2+](i) and UCP1 expression, increased mitochondrial membrane potential, glucose uptake and heat production.	icilin	137-143	uncoupling protein 1	Homo sapiens	176-180
24256707-3	2014	We investigated whether nebivolol is able to induce beta3AR-mediated lipolysis, uncoupling protein 1 (UCP1), and size-reduction in human adipocytes.	Nebivolol	24-33	uncoupling protein 1	Homo sapiens	102-106
24314860-5	2014	Concomitantly, the polyphenols modulate signaling pathways including the adenosine-monophosphate-activated protein kinase, peroxisome proliferator activated receptor gamma, CCAAT/enhancer binding protein alpha, peroxisome proliferator activator receptor gamma activator 1-alpha, sirtuin 1, sterol regulatory element binding protein-1c, uncoupling proteins 1 and 2, and nuclear factor-kappaB that regulate adipogenesis, antioxidant and anti-inflammatory responses.	Polyphenols	19-30	uncoupling protein 1	Homo sapiens	290-363
23008094-3	2013	Primary cultures were treated with genipin, a proton leak inhibitor, guanosine diphosphate (GDP), an UCP inhibitor, and triiodothyronine (T3), an inducer of UCP gene expression.	Triiodothyronine	120-136	uncoupling protein 1	Homo sapiens	157-160
24196960-4	2013	Overexpressed UCP1 in bacterial membranes was extracted using mild detergents and reconstituted into phospholipid bilayers for biochemical studies.	Phospholipids	101-113	uncoupling protein 1	Homo sapiens	14-18
24196960-5	2013	UCP1 was folded in octyl glucoside, as indicated by its high helical content and binding to ATP, a known UCP1 proton transport inhibitor.	octyl-beta-D-glucoside	19-34	uncoupling protein 1	Homo sapiens	0-4
24196960-5	2013	UCP1 was folded in octyl glucoside, as indicated by its high helical content and binding to ATP, a known UCP1 proton transport inhibitor.	octyl-beta-D-glucoside	19-34	uncoupling protein 1	Homo sapiens	105-109
24196960-5	2013	UCP1 was folded in octyl glucoside, as indicated by its high helical content and binding to ATP, a known UCP1 proton transport inhibitor.	Adenosine Triphosphate	92-95	uncoupling protein 1	Homo sapiens	0-4
24196960-5	2013	UCP1 was folded in octyl glucoside, as indicated by its high helical content and binding to ATP, a known UCP1 proton transport inhibitor.	Adenosine Triphosphate	92-95	uncoupling protein 1	Homo sapiens	105-109
24196960-6	2013	Reconstituted UCP1 in phospholipid vesicles also exhibited highly helical structures and proton transport that is activated by fatty acids and inhibited by purine nucleotides.	Phospholipids	22-34	uncoupling protein 1	Homo sapiens	14-18
24196960-6	2013	Reconstituted UCP1 in phospholipid vesicles also exhibited highly helical structures and proton transport that is activated by fatty acids and inhibited by purine nucleotides.	Fatty Acids	127-138	uncoupling protein 1	Homo sapiens	14-18
24196960-6	2013	Reconstituted UCP1 in phospholipid vesicles also exhibited highly helical structures and proton transport that is activated by fatty acids and inhibited by purine nucleotides.	Purine Nucleotides	156-174	uncoupling protein 1	Homo sapiens	14-18
23008094-3	2013	Primary cultures were treated with genipin, a proton leak inhibitor, guanosine diphosphate (GDP), an UCP inhibitor, and triiodothyronine (T3), an inducer of UCP gene expression.	Triiodothyronine	138-140	uncoupling protein 1	Homo sapiens	157-160
23906633-6	2013	Here we show, using human patient samples from individuals with hereditary vitamin D resistant rickets, that the VDR directly inhibits the expression of uncoupling protein-1 (UCP1), the critical protein for uncoupling fatty acid oxidation in brown fat and burning energy.	Vitamin D	75-84	uncoupling protein 1	Homo sapiens	153-179
23906633-6	2013	Here we show, using human patient samples from individuals with hereditary vitamin D resistant rickets, that the VDR directly inhibits the expression of uncoupling protein-1 (UCP1), the critical protein for uncoupling fatty acid oxidation in brown fat and burning energy.	Fatty Acids	218-228	uncoupling protein 1	Homo sapiens	153-179
22727960-6	2013	EAT expression of UCP1 (r=0.50), COX-IV (r=0.37) and lipoprotein lipase (LPL) (r=0.58) positively associated with circulating levels of HDL-cholesterol (P &lt;= 0.05).	Cholesterol	140-151	uncoupling protein 1	Homo sapiens	18-22
23781029-8	2013	Finally, non-Pax3 lineage beige adipocytes are more responsive to cAMP-agonist-induced Ucp1 expression.	Cyclic AMP	66-70	uncoupling protein 1	Homo sapiens	87-91
23146742-4	2013	In this context, adipocytes can be converted, within white adipose tissue (WAT), into multilocular adipocytes expressing UCP1, a mitochondrial protein that plays a key role in heat production by uncoupling the activity of the respiratory chain from ATP synthesis.	Adenosine Triphosphate	249-252	uncoupling protein 1	Homo sapiens	121-125
23551955-1	2013	AIM: The aim of this study was to determine whether the use of transcervical balloon catheter (TCBC) for induction of labor (IOL) is a risk factor for cerebral palsy (CP) associated with umbilical cord prolapse (UCP-CP) in singleton pregnancies with cephalic presentation.	1,3,5-Trichloro-2-(chloromethyl)benzene	95-99	uncoupling protein 1	Homo sapiens	212-215
23551955-5	2013	Only TCBC was a risk factor significantly associated with UCP-CP after logistic regression analysis, yielding an odds ratio of 18.0 (95% confidence interval, 2.6-124; P = 0.003).	1,3,5-Trichloro-2-(chloromethyl)benzene	5-9	uncoupling protein 1	Homo sapiens	58-61
23551955-6	2013	Saline volumes of 80-150 mL were used for TCBC inflation in the four UCP-CP patients.	Sodium Chloride	0-6	uncoupling protein 1	Homo sapiens	69-72
23551955-7	2013	CONCLUSION: Use of TCBC with a saline volume &gt;= 80 mL was a significant risk factor for UCP-CP; however, the absolute risk of UCP-CP was estimated to be very low, approximately one in 7875 TCBC users.	1,3,5-Trichloro-2-(chloromethyl)benzene	19-23	uncoupling protein 1	Homo sapiens	91-94
23551955-7	2013	CONCLUSION: Use of TCBC with a saline volume &gt;= 80 mL was a significant risk factor for UCP-CP; however, the absolute risk of UCP-CP was estimated to be very low, approximately one in 7875 TCBC users.	1,3,5-Trichloro-2-(chloromethyl)benzene	19-23	uncoupling protein 1	Homo sapiens	129-132
23671714-9	2013	In agreement with the notion of a decrease in avUCP expression in response to heat stress, proton leak, which was likely mediated by UCP (that part which is GDP-inhibited and arachidonic acid-sensitive), was reduced in the heat-exposed group.	Guanosine Diphosphate	157-160	uncoupling protein 1	Homo sapiens	48-51
23671714-9	2013	In agreement with the notion of a decrease in avUCP expression in response to heat stress, proton leak, which was likely mediated by UCP (that part which is GDP-inhibited and arachidonic acid-sensitive), was reduced in the heat-exposed group.	Arachidonic Acid	175-191	uncoupling protein 1	Homo sapiens	48-51
23554809-0	2013	Synergism between cAMP and PPARgamma Signalling in the Initiation of UCP1 Gene Expression in HIB1B Brown Adipocytes.	Cyclic AMP	18-22	uncoupling protein 1	Homo sapiens	69-73
23302779-4	2013	The coculture with RAW264.7 (RAW) macrophages suppressed the induction of UCP1 mRNA expression by isoproterenol (ISO), a typical beta-adrenergic receptor agonist, in C3H10T1/2 (10T1/2) adipocytes.	Isoproterenol	98-111	uncoupling protein 1	Homo sapiens	74-78
23302779-4	2013	The coculture with RAW264.7 (RAW) macrophages suppressed the induction of UCP1 mRNA expression by isoproterenol (ISO), a typical beta-adrenergic receptor agonist, in C3H10T1/2 (10T1/2) adipocytes.	Isoproterenol	113-116	uncoupling protein 1	Homo sapiens	74-78
24432128-2	2013	In this study, we investigated whether fatty acid chain length had any bearing on the ability of glucose-O-omega-fatty acids to activate uncoupling protein 1.	glucose-o-omega-fatty acids	97-124	uncoupling protein 1	Homo sapiens	137-157
24432128-3	2013	Glucose-O-omega-saturated fatty acids of various chain lengths were synthesized and tested for their potential to activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, and the results were compared with equivalent non-modified fatty acid controls.	glucose-o-omega-saturated fatty acids	0-37	uncoupling protein 1	Homo sapiens	137-157
24432128-3	2013	Glucose-O-omega-saturated fatty acids of various chain lengths were synthesized and tested for their potential to activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, and the results were compared with equivalent non-modified fatty acid controls.	Guanosine Diphosphate	123-126	uncoupling protein 1	Homo sapiens	137-157
24432128-3	2013	Glucose-O-omega-saturated fatty acids of various chain lengths were synthesized and tested for their potential to activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, and the results were compared with equivalent non-modified fatty acid controls.	Oxygen	168-174	uncoupling protein 1	Homo sapiens	137-157
24432128-3	2013	Glucose-O-omega-saturated fatty acids of various chain lengths were synthesized and tested for their potential to activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, and the results were compared with equivalent non-modified fatty acid controls.	Fatty Acids	26-36	uncoupling protein 1	Homo sapiens	137-157
24432128-4	2013	Here we demonstrate that laurate (12C), palmitate (16C) and stearate (18C) could activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, whereas there was no activation with glucose-O-omega-laurate (12C), glucose-O-omega-palmitate (16C), glucose-O-omega-stearate (18C), glucose-O-omega-arachidate (20C) or arachidate alone.	Laurates	25-32	uncoupling protein 1	Homo sapiens	104-124
24432128-4	2013	Here we demonstrate that laurate (12C), palmitate (16C) and stearate (18C) could activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, whereas there was no activation with glucose-O-omega-laurate (12C), glucose-O-omega-palmitate (16C), glucose-O-omega-stearate (18C), glucose-O-omega-arachidate (20C) or arachidate alone.	5-(2-formyl-3-hydroxyphenoxy)pentanoic acid	34-37	uncoupling protein 1	Homo sapiens	104-124
24432128-4	2013	Here we demonstrate that laurate (12C), palmitate (16C) and stearate (18C) could activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, whereas there was no activation with glucose-O-omega-laurate (12C), glucose-O-omega-palmitate (16C), glucose-O-omega-stearate (18C), glucose-O-omega-arachidate (20C) or arachidate alone.	Palmitates	40-49	uncoupling protein 1	Homo sapiens	104-124
24432128-4	2013	Here we demonstrate that laurate (12C), palmitate (16C) and stearate (18C) could activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, whereas there was no activation with glucose-O-omega-laurate (12C), glucose-O-omega-palmitate (16C), glucose-O-omega-stearate (18C), glucose-O-omega-arachidate (20C) or arachidate alone.	16c	51-54	uncoupling protein 1	Homo sapiens	104-124
24432128-4	2013	Here we demonstrate that laurate (12C), palmitate (16C) and stearate (18C) could activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, whereas there was no activation with glucose-O-omega-laurate (12C), glucose-O-omega-palmitate (16C), glucose-O-omega-stearate (18C), glucose-O-omega-arachidate (20C) or arachidate alone.	Stearates	60-68	uncoupling protein 1	Homo sapiens	104-124
24432128-4	2013	Here we demonstrate that laurate (12C), palmitate (16C) and stearate (18C) could activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, whereas there was no activation with glucose-O-omega-laurate (12C), glucose-O-omega-palmitate (16C), glucose-O-omega-stearate (18C), glucose-O-omega-arachidate (20C) or arachidate alone.	18c	70-73	uncoupling protein 1	Homo sapiens	104-124
24432128-4	2013	Here we demonstrate that laurate (12C), palmitate (16C) and stearate (18C) could activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, whereas there was no activation with glucose-O-omega-laurate (12C), glucose-O-omega-palmitate (16C), glucose-O-omega-stearate (18C), glucose-O-omega-arachidate (20C) or arachidate alone.	Guanosine Diphosphate	90-93	uncoupling protein 1	Homo sapiens	104-124
24432128-4	2013	Here we demonstrate that laurate (12C), palmitate (16C) and stearate (18C) could activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, whereas there was no activation with glucose-O-omega-laurate (12C), glucose-O-omega-palmitate (16C), glucose-O-omega-stearate (18C), glucose-O-omega-arachidate (20C) or arachidate alone.	Oxygen	135-141	uncoupling protein 1	Homo sapiens	104-124
24432128-4	2013	Here we demonstrate that laurate (12C), palmitate (16C) and stearate (18C) could activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, whereas there was no activation with glucose-O-omega-laurate (12C), glucose-O-omega-palmitate (16C), glucose-O-omega-stearate (18C), glucose-O-omega-arachidate (20C) or arachidate alone.	5-(2-formyl-3-hydroxyphenoxy)pentanoic acid	254-257	uncoupling protein 1	Homo sapiens	104-124
24432128-4	2013	Here we demonstrate that laurate (12C), palmitate (16C) and stearate (18C) could activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, whereas there was no activation with glucose-O-omega-laurate (12C), glucose-O-omega-palmitate (16C), glucose-O-omega-stearate (18C), glucose-O-omega-arachidate (20C) or arachidate alone.	glucose-o-omega-palmitate	260-285	uncoupling protein 1	Homo sapiens	104-124
24432128-4	2013	Here we demonstrate that laurate (12C), palmitate (16C) and stearate (18C) could activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, whereas there was no activation with glucose-O-omega-laurate (12C), glucose-O-omega-palmitate (16C), glucose-O-omega-stearate (18C), glucose-O-omega-arachidate (20C) or arachidate alone.	16c	287-290	uncoupling protein 1	Homo sapiens	104-124
24432128-4	2013	Here we demonstrate that laurate (12C), palmitate (16C) and stearate (18C) could activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, whereas there was no activation with glucose-O-omega-laurate (12C), glucose-O-omega-palmitate (16C), glucose-O-omega-stearate (18C), glucose-O-omega-arachidate (20C) or arachidate alone.	glucose-o-omega-stearate	293-317	uncoupling protein 1	Homo sapiens	104-124
24432128-4	2013	Here we demonstrate that laurate (12C), palmitate (16C) and stearate (18C) could activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, whereas there was no activation with glucose-O-omega-laurate (12C), glucose-O-omega-palmitate (16C), glucose-O-omega-stearate (18C), glucose-O-omega-arachidate (20C) or arachidate alone.	glucose-o-omega-arachidate	325-351	uncoupling protein 1	Homo sapiens	104-124
24432128-4	2013	Here we demonstrate that laurate (12C), palmitate (16C) and stearate (18C) could activate GDP-inhibited uncoupling protein 1-dependent oxygen consumption in brown adipose tissue mitochondria, whereas there was no activation with glucose-O-omega-laurate (12C), glucose-O-omega-palmitate (16C), glucose-O-omega-stearate (18C), glucose-O-omega-arachidate (20C) or arachidate alone.	arachidic acid	341-351	uncoupling protein 1	Homo sapiens	104-124
24432128-6	2013	Our data further undermine the cofactor activation model of uncoupling protein 1 function but are compatible with the model that uncoupling protein 1 functions by flipping long-chain fatty acid anions.	long-chain fatty acid	172-193	uncoupling protein 1	Homo sapiens	129-149
23414455-1	2013	A tight regulation of proton transport in the inner mitochondrial membrane is crucial for physiological processes such as ATP synthesis, heat production, or regulation of the reactive oxygen species as proposed for the uncoupling protein family members (UCP).	Reactive Oxygen Species	175-198	uncoupling protein 1	Homo sapiens	254-257
23414455-3	2013	We and other research groups have shown previously that UCP1- and UCP2-mediated proton transport is inhibited by purine nucleotides.	Purine Nucleotides	113-131	uncoupling protein 1	Homo sapiens	56-60
23414455-7	2013	The comparison of recognition patterns obtained with anti-UCP1 antibody and ATP led to the conclusion that the ATP binding site can be accessed from both sides of the membrane.	Adenosine Triphosphate	111-114	uncoupling protein 1	Homo sapiens	58-62
23036787-0	2013	Uncoupling protein 1 dependent reactive oxygen species production by thymus mitochondria.	Reactive Oxygen Species	31-54	uncoupling protein 1	Homo sapiens	0-20
23036787-2	2013	As reactive oxygen species have been implicated in T-cell development, we set out to determine whether uncoupling protein 1 had the potential to regulate reactive oxygen species production in mitochondria isolated from thymus.	Reactive Oxygen Species	154-177	uncoupling protein 1	Homo sapiens	103-123
23036787-3	2013	This was achieved by inhibiting proton leak through uncoupling protein 1 using the purine nucleotide GDP and through ablation of uncoupling protein 1, measuring the amplex red sensitive reactive oxygen species production by mitochondria.	purine	83-89	uncoupling protein 1	Homo sapiens	52-72
23036787-3	2013	This was achieved by inhibiting proton leak through uncoupling protein 1 using the purine nucleotide GDP and through ablation of uncoupling protein 1, measuring the amplex red sensitive reactive oxygen species production by mitochondria.	Guanosine Diphosphate	101-104	uncoupling protein 1	Homo sapiens	52-72
23036787-3	2013	This was achieved by inhibiting proton leak through uncoupling protein 1 using the purine nucleotide GDP and through ablation of uncoupling protein 1, measuring the amplex red sensitive reactive oxygen species production by mitochondria.	Reactive Oxygen Species	186-209	uncoupling protein 1	Homo sapiens	129-149
23036787-4	2013	In this work we demonstrate, for the first time, that uncoupling protein 1 has the potential to regulate reactive oxygen species production in thymus mitochondria.	Reactive Oxygen Species	105-128	uncoupling protein 1	Homo sapiens	54-74
23302779-6	2013	By using a luciferase reporter assay system, the conditioned medium and TNF-alpha also suppressed the activity of the UCP1 promoter and transcriptional factors binding to the cAMP response element (CRE).	Cyclic AMP	175-179	uncoupling protein 1	Homo sapiens	118-122
23302779-7	2013	Importantly, PD98059, an ERK inhibitor, partially abrogated the suppression of UCP1 promoter activation and mRNA induction.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	13-20	uncoupling protein 1	Homo sapiens	79-83
23404793-6	2013	This ERRgamma-induced augmentation of UCP1 expression was independent of the presence of peroxisome proliferator-activated receptor coactivator-1 (PGC-1alpha) but was associated with increased rates of fatty acid oxidation in adrenergically stimulated cells.	Fatty Acids	202-212	uncoupling protein 1	Homo sapiens	38-42
23257779-7	2013	More specifically, overexpression of UCP-1 in stromal fibroblasts increases beta-oxidation, ketone body production and the release of ATP-rich vesicles, which "fuels" tumor growth by providing high-energy nutrients in a paracrine fashion to epithelial cancer cells.	Ketones	92-98	uncoupling protein 1	Homo sapiens	37-42
23676126-1	2013	Brown adipose tissue (BAT) dissipates energy stored in triglycerides as heat via the uncoupling protein UCP1.	Triglycerides	55-68	uncoupling protein 1	Homo sapiens	104-108
23554809-6	2013	We conclude that rosiglitazone and forskolin act together to synergistically activate the UCP1 promoter directly rather than by increasing PGC1alpha expression and by a mechanism involving cross-talk between the signalling systems regulating the CRE and PPRE on the promoters.	Colforsin	35-44	uncoupling protein 1	Homo sapiens	90-94
23554809-1	2013	Expression of the brown adipocyte-specific gene, uncoupling protein 1 (UCP1), is increased by both PPARgamma stimulation and cAMP activation through their ability to stimulate the expression of the PPAR coactivator PGC1alpha.	Cyclic AMP	125-129	uncoupling protein 1	Homo sapiens	71-75
23554809-2	2013	In HIB1B brown preadipocytes, combination of the PPARgamma agonist, rosiglitazone, and the cAMP stimulator forskolin synergistically increased UCP1 mRNA expression, but PGC1alpha expression was only increased additively by the two drugs.	Rosiglitazone	68-81	uncoupling protein 1	Homo sapiens	143-147
23554809-2	2013	In HIB1B brown preadipocytes, combination of the PPARgamma agonist, rosiglitazone, and the cAMP stimulator forskolin synergistically increased UCP1 mRNA expression, but PGC1alpha expression was only increased additively by the two drugs.	Cyclic AMP	91-95	uncoupling protein 1	Homo sapiens	143-147
23554809-2	2013	In HIB1B brown preadipocytes, combination of the PPARgamma agonist, rosiglitazone, and the cAMP stimulator forskolin synergistically increased UCP1 mRNA expression, but PGC1alpha expression was only increased additively by the two drugs.	Colforsin	107-116	uncoupling protein 1	Homo sapiens	143-147
23554809-3	2013	The PPARgamma antagonist, GW9662, and the PKA inhibitor, H89, both inhibited UCP1 expression stimulated by rosiglitazone and forskolin but PGC1alpha expression was not altered to the same extent.	2-chloro-5-nitrobenzanilide	26-32	uncoupling protein 1	Homo sapiens	77-81
23554809-3	2013	The PPARgamma antagonist, GW9662, and the PKA inhibitor, H89, both inhibited UCP1 expression stimulated by rosiglitazone and forskolin but PGC1alpha expression was not altered to the same extent.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	57-60	uncoupling protein 1	Homo sapiens	77-81
23554809-3	2013	The PPARgamma antagonist, GW9662, and the PKA inhibitor, H89, both inhibited UCP1 expression stimulated by rosiglitazone and forskolin but PGC1alpha expression was not altered to the same extent.	Rosiglitazone	107-120	uncoupling protein 1	Homo sapiens	77-81
23554809-3	2013	The PPARgamma antagonist, GW9662, and the PKA inhibitor, H89, both inhibited UCP1 expression stimulated by rosiglitazone and forskolin but PGC1alpha expression was not altered to the same extent.	Colforsin	125-134	uncoupling protein 1	Homo sapiens	77-81
23554809-4	2013	Reporter studies demonstrated that combined rosiglitazone and forskolin synergistically activated transcription from a full length 3.1 kbp UCP1 luciferase promoter construct, but the response was only additive and much reduced when a minimal 260 bp proximal UCP1 promoter was examined.	Rosiglitazone	44-57	uncoupling protein 1	Homo sapiens	139-143
23554809-4	2013	Reporter studies demonstrated that combined rosiglitazone and forskolin synergistically activated transcription from a full length 3.1 kbp UCP1 luciferase promoter construct, but the response was only additive and much reduced when a minimal 260 bp proximal UCP1 promoter was examined.	Rosiglitazone	44-57	uncoupling protein 1	Homo sapiens	258-262
23554809-4	2013	Reporter studies demonstrated that combined rosiglitazone and forskolin synergistically activated transcription from a full length 3.1 kbp UCP1 luciferase promoter construct, but the response was only additive and much reduced when a minimal 260 bp proximal UCP1 promoter was examined.	Colforsin	62-71	uncoupling protein 1	Homo sapiens	139-143
23554809-4	2013	Reporter studies demonstrated that combined rosiglitazone and forskolin synergistically activated transcription from a full length 3.1 kbp UCP1 luciferase promoter construct, but the response was only additive and much reduced when a minimal 260 bp proximal UCP1 promoter was examined.	Colforsin	62-71	uncoupling protein 1	Homo sapiens	258-262
23554809-6	2013	We conclude that rosiglitazone and forskolin act together to synergistically activate the UCP1 promoter directly rather than by increasing PGC1alpha expression and by a mechanism involving cross-talk between the signalling systems regulating the CRE and PPRE on the promoters.	Rosiglitazone	17-30	uncoupling protein 1	Homo sapiens	90-94
23063128-0	2012	Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria.	Fatty Acids	13-23	uncoupling protein 1	Homo sapiens	34-38
23033381-1	2012	PURPOSE: Uncoupling protein 1 (UCP1) reduces mitochondrial production of reactive oxygen species (ROS).	Reactive Oxygen Species	73-96	uncoupling protein 1	Homo sapiens	0-29
23033381-1	2012	PURPOSE: Uncoupling protein 1 (UCP1) reduces mitochondrial production of reactive oxygen species (ROS).	Reactive Oxygen Species	73-96	uncoupling protein 1	Homo sapiens	31-35
23033381-1	2012	PURPOSE: Uncoupling protein 1 (UCP1) reduces mitochondrial production of reactive oxygen species (ROS).	Reactive Oxygen Species	98-101	uncoupling protein 1	Homo sapiens	0-29
23033381-1	2012	PURPOSE: Uncoupling protein 1 (UCP1) reduces mitochondrial production of reactive oxygen species (ROS).	Reactive Oxygen Species	98-101	uncoupling protein 1	Homo sapiens	31-35
22952235-0	2012	Fatty acids change the conformation of uncoupling protein 1 (UCP1).	Fatty Acids	0-11	uncoupling protein 1	Homo sapiens	39-59
22952235-0	2012	Fatty acids change the conformation of uncoupling protein 1 (UCP1).	Fatty Acids	0-11	uncoupling protein 1	Homo sapiens	61-65
22952235-1	2012	UCP1 catalyzes proton leak across the mitochondrial inner membrane to disengage substrate oxidation from ATP production.	Adenosine Triphosphate	105-108	uncoupling protein 1	Homo sapiens	0-4
22952235-2	2012	It is well established that UCP1 is activated by fatty acids and inhibited by purine nucleotides, but precisely how this regulation occurs remains unsettled.	Fatty Acids	49-60	uncoupling protein 1	Homo sapiens	28-32
22952235-2	2012	It is well established that UCP1 is activated by fatty acids and inhibited by purine nucleotides, but precisely how this regulation occurs remains unsettled.	Purine Nucleotides	78-96	uncoupling protein 1	Homo sapiens	28-32
22952235-4	2012	Here, we present the first demonstration that fatty acids induce a conformational change in UCP1.	Fatty Acids	46-57	uncoupling protein 1	Homo sapiens	92-96
22952235-5	2012	Palmitate dramatically changed the binding kinetics of 2"/3"-O-(N-methylanthraniloyl)-GDP, a fluorescently labeled nucleotide analog, for UCP1.	Palmitates	0-9	uncoupling protein 1	Homo sapiens	138-142
22952235-5	2012	Palmitate dramatically changed the binding kinetics of 2"/3"-O-(N-methylanthraniloyl)-GDP, a fluorescently labeled nucleotide analog, for UCP1.	2"/3"-o-(n-methylanthraniloyl)-gdp	55-89	uncoupling protein 1	Homo sapiens	138-142
22952235-6	2012	Furthermore, palmitate accelerated the rate of enzymatic proteolysis of UCP1.	Palmitates	13-22	uncoupling protein 1	Homo sapiens	72-76
22952235-7	2012	The altered kinetics of both processes indicate that fatty acids change the conformation of UCP1, reconciling the apparent discrepancy between existing functional and ligand binding data.	Fatty Acids	53-64	uncoupling protein 1	Homo sapiens	92-96
22952235-8	2012	Our results provide a framework for how fatty acids and nucleotides compete to regulate the activity of UCP1.	Fatty Acids	40-51	uncoupling protein 1	Homo sapiens	104-108
23063128-2	2012	Upon activation by long-chain fatty acids (LCFAs), UCP1 increases the conductance of the inner mitochondrial membrane (IMM) to make BAT mitochondria generate heat rather than ATP.	long-chain fatty acids	19-41	uncoupling protein 1	Homo sapiens	51-55
23063128-2	2012	Upon activation by long-chain fatty acids (LCFAs), UCP1 increases the conductance of the inner mitochondrial membrane (IMM) to make BAT mitochondria generate heat rather than ATP.	lcfas	43-48	uncoupling protein 1	Homo sapiens	51-55
23063128-2	2012	Upon activation by long-chain fatty acids (LCFAs), UCP1 increases the conductance of the inner mitochondrial membrane (IMM) to make BAT mitochondria generate heat rather than ATP.	Adenosine Triphosphate	175-178	uncoupling protein 1	Homo sapiens	51-55
22531154-5	2012	In addition, we demonstrate that the cytoplasmic proteasome is required for UCP1 degradation from mitochondria that the process is inhibited by the proteasome inhibitor MG132 and that dissipation of the mitochondrial membrane potential inhibits degradation of UCP1.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	169-174	uncoupling protein 1	Homo sapiens	76-80
23043591-5	2012	In this study, we elucidated the association of three polymorphisms located in the UCP-1 promoter and coding region with DP among Korean stroke patients.	dp	121-123	uncoupling protein 1	Homo sapiens	83-88
23043591-8	2012	The results were analyzed using a multiple logistic regression model to evaluate the genetic associations: the UCP-1polymorphisms of normal versus those of DP subjects and those of normal versus those of non-DP subjects.	dp	156-158	uncoupling protein 1	Homo sapiens	111-116
23043591-11	2012	In addition, an analysis of the relationship among 2 SNPs of UCP-1 and lipid serum concentration showed that the serum level of HDL cholesterol was significantly higher in subjects with the A-3826G G allele in the normal group (p=0.032).	Cholesterol	132-143	uncoupling protein 1	Homo sapiens	61-66
23043591-13	2012	CONCLUSIONS: These results suggest that that the A-3826G and A-1766G UCP-1 polymorphisms, which are related to obesity, might be candidate genetic markers for the DP pattern in the TKM diagnosis system.	dp	163-165	uncoupling protein 1	Homo sapiens	69-74
22531154-5	2012	In addition, we demonstrate that the cytoplasmic proteasome is required for UCP1 degradation from mitochondria that the process is inhibited by the proteasome inhibitor MG132 and that dissipation of the mitochondrial membrane potential inhibits degradation of UCP1.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	169-174	uncoupling protein 1	Homo sapiens	260-264
22676960-6	2012	In this cell-based test system UCP1 displays native functional behaviour as it can be activated with fatty acids (palmitate) and inhibited with purine nucleotides guanosine-diphosphate (GDP).	Fatty Acids	101-112	uncoupling protein 1	Homo sapiens	31-35
22956852-6	2012	In addition, this effect was compensated by SIRT1 overexpression and accompanied by the modulation of neuronal UCP expression levels, further highlighting a cross-talk between beta-catenin and SIRT1 in the modulation of mutant polyQ cytoxicity.	polyglutamine	227-232	uncoupling protein 1	Homo sapiens	111-114
22676960-6	2012	In this cell-based test system UCP1 displays native functional behaviour as it can be activated with fatty acids (palmitate) and inhibited with purine nucleotides guanosine-diphosphate (GDP).	Palmitates	114-123	uncoupling protein 1	Homo sapiens	31-35
22676960-6	2012	In this cell-based test system UCP1 displays native functional behaviour as it can be activated with fatty acids (palmitate) and inhibited with purine nucleotides guanosine-diphosphate (GDP).	Purine Nucleotides	144-162	uncoupling protein 1	Homo sapiens	31-35
22676960-6	2012	In this cell-based test system UCP1 displays native functional behaviour as it can be activated with fatty acids (palmitate) and inhibited with purine nucleotides guanosine-diphosphate (GDP).	Guanosine Diphosphate	163-184	uncoupling protein 1	Homo sapiens	31-35
22676960-6	2012	In this cell-based test system UCP1 displays native functional behaviour as it can be activated with fatty acids (palmitate) and inhibited with purine nucleotides guanosine-diphosphate (GDP).	Guanosine Diphosphate	186-189	uncoupling protein 1	Homo sapiens	31-35
22796012-4	2012	Beige cells resemble white fat cells in having extremely low basal expression of UCP1, but, like classical brown fat, they respond to cyclic AMP stimulation with high UCP1 expression and respiration rates.	Cyclic AMP	134-144	uncoupling protein 1	Homo sapiens	167-171
21940996-8	2012	When redox status was subsequently increased (i.e., more reduced), UCP1-mediated uncoupling was more sensitive to GDP inhibition.	Guanosine Diphosphate	114-117	uncoupling protein 1	Homo sapiens	67-71
22611357-6	2012	These works revealed FX mediated induction of uncoupling protein-1 (UCP-1) in abdominal white adipose tissue (WAT) mitochondria, leading to the oxidation of fatty acids and heat production in WAT.	Fatty Acids	157-168	uncoupling protein 1	Homo sapiens	46-73
21561434-2	2012	The activity of UCP1 is modulated by GDP and fatty acids.	Guanosine Diphosphate	37-40	uncoupling protein 1	Homo sapiens	16-20
21561434-2	2012	The activity of UCP1 is modulated by GDP and fatty acids.	Fatty Acids	45-56	uncoupling protein 1	Homo sapiens	16-20
22075692-0	2012	Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes.	Triiodothyronine	0-16	uncoupling protein 1	Homo sapiens	25-30
22075692-7	2012	In this study, triiodothyronine (T(3)) treatment induced UCP-1 expression and mitochondrial biogenesis, accompanied by the induction of the CCAAT/enhancer binding protein, peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and nuclear respiratory factor-1 in differentiated human multipotent adipose-derived stem cells.	Triiodothyronine	15-31	uncoupling protein 1	Homo sapiens	57-62
22075692-7	2012	In this study, triiodothyronine (T(3)) treatment induced UCP-1 expression and mitochondrial biogenesis, accompanied by the induction of the CCAAT/enhancer binding protein, peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and nuclear respiratory factor-1 in differentiated human multipotent adipose-derived stem cells.	Triiodothyronine	33-37	uncoupling protein 1	Homo sapiens	57-62
22075692-10	2012	These findings indicate that T(3) is an active modulator, which induces energy utilization in white adipocytes through the regulation of UCP-1 expression and mitochondrial biogenesis.	Triiodothyronine	29-33	uncoupling protein 1	Homo sapiens	137-142
22260858-7	2012	Doenjang supplementation significantly reduced visceral fat and increased the free fatty acid concentrations in subjects with the G allele of the UCP-1 polymorphism, which suggests that doenjang may be related to increased free fatty acid levels caused by elevated lipolysis in these subjects.	doenjang	0-8	uncoupling protein 1	Homo sapiens	146-151
22260858-7	2012	Doenjang supplementation significantly reduced visceral fat and increased the free fatty acid concentrations in subjects with the G allele of the UCP-1 polymorphism, which suggests that doenjang may be related to increased free fatty acid levels caused by elevated lipolysis in these subjects.	Fatty Acids, Nonesterified	78-93	uncoupling protein 1	Homo sapiens	146-151
22260858-7	2012	Doenjang supplementation significantly reduced visceral fat and increased the free fatty acid concentrations in subjects with the G allele of the UCP-1 polymorphism, which suggests that doenjang may be related to increased free fatty acid levels caused by elevated lipolysis in these subjects.	Fatty Acids, Nonesterified	223-238	uncoupling protein 1	Homo sapiens	146-151
21433011-5	2011	Nutrigenomic studies reveal that fucoxanthin induces UCP1 in abdominal WAT mitochondria, leading to the oxidation of fatty acids and heat production in WAT.	fucoxanthin	33-44	uncoupling protein 1	Homo sapiens	53-57
22101429-3	2011	Acting via the beta(3)-adrenergic receptors, noradrenaline induces lipolysis in white adipocytes, whereas it stimulates the expression of thermogenic genes, such as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long-chain family member 1 (Acsl1), in brown adipocytes.	Norepinephrine	45-58	uncoupling protein 1	Homo sapiens	203-223
22101429-3	2011	Acting via the beta(3)-adrenergic receptors, noradrenaline induces lipolysis in white adipocytes, whereas it stimulates the expression of thermogenic genes, such as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long-chain family member 1 (Acsl1), in brown adipocytes.	Norepinephrine	45-58	uncoupling protein 1	Homo sapiens	225-229
21542606-12	2011	In this way, magnetic AFM tips could be functionalized with an ethylene diamine derivative of ATP which showed specific interaction with mitochondrial uncoupling protein 1 (UCP1) that had been purified and reconstituted in a mica-supported planar lipid bilayer.	ethylenediamine	63-79	uncoupling protein 1	Homo sapiens	173-177
21542606-12	2011	In this way, magnetic AFM tips could be functionalized with an ethylene diamine derivative of ATP which showed specific interaction with mitochondrial uncoupling protein 1 (UCP1) that had been purified and reconstituted in a mica-supported planar lipid bilayer.	Adenosine Triphosphate	94-97	uncoupling protein 1	Homo sapiens	173-177
21542606-12	2011	In this way, magnetic AFM tips could be functionalized with an ethylene diamine derivative of ATP which showed specific interaction with mitochondrial uncoupling protein 1 (UCP1) that had been purified and reconstituted in a mica-supported planar lipid bilayer.	mica	225-229	uncoupling protein 1	Homo sapiens	173-177
22649389-3	2011	By this process, UCP1 uncouples respiration from ATP synthesis and therefore provokes energy dissipation in the form of heat while, also stimulating high levels of fatty acid oxidation.	Adenosine Triphosphate	49-52	uncoupling protein 1	Homo sapiens	17-21
22649389-3	2011	By this process, UCP1 uncouples respiration from ATP synthesis and therefore provokes energy dissipation in the form of heat while, also stimulating high levels of fatty acid oxidation.	Fatty Acids	164-174	uncoupling protein 1	Homo sapiens	17-21
22393344-1	2011	BACKGROUND: Limited studies have shown inconsistent data about the association between the uncoupling protein 1 (UCP1) gene A-3826G polymorphism and high-density lipoprotein (HDL) cholesterol levels.	Cholesterol	180-191	uncoupling protein 1	Homo sapiens	91-111
22393344-1	2011	BACKGROUND: Limited studies have shown inconsistent data about the association between the uncoupling protein 1 (UCP1) gene A-3826G polymorphism and high-density lipoprotein (HDL) cholesterol levels.	Cholesterol	180-191	uncoupling protein 1	Homo sapiens	113-117
22393344-8	2011	CONCLUSIONS: The obesity status could have opposing impacts on the relationship between the G/G genotype and low HDL-cholesterolemia, providing insight into the need to consider the obesity levels when studying the association between the UCP-1 gene A-3826G polymorphism and HDL-cholesterol.	Cholesterol	117-128	uncoupling protein 1	Homo sapiens	239-244
21762777-8	2011	Hence, our findings are consistent with the notion that UCPs 2 and 3 are acutely activated by ROS, which then directly modulate the glutathionylation status of the UCP to decrease ROS emission and participate in cell signaling mechanisms.	Reactive Oxygen Species	94-97	uncoupling protein 1	Homo sapiens	56-59
21762777-8	2011	Hence, our findings are consistent with the notion that UCPs 2 and 3 are acutely activated by ROS, which then directly modulate the glutathionylation status of the UCP to decrease ROS emission and participate in cell signaling mechanisms.	Reactive Oxygen Species	180-183	uncoupling protein 1	Homo sapiens	56-59
21712825-3	2011	In addition, UCP suppress the generation of superoxide, a byproduct of mitochondrial electron transport and a major source of oxidative stress.	Superoxides	44-54	uncoupling protein 1	Homo sapiens	13-16
21433011-5	2011	Nutrigenomic studies reveal that fucoxanthin induces UCP1 in abdominal WAT mitochondria, leading to the oxidation of fatty acids and heat production in WAT.	Fatty Acids	117-128	uncoupling protein 1	Homo sapiens	53-57
21196229-5	2011	UCP1 uncouples adenosine-5"-triphosphate (ATP) synthesis from substrate oxidation in brown adipocytes.	Adenosine Triphosphate	15-40	uncoupling protein 1	Homo sapiens	0-4
21338923-3	2011	Screening of potential UCP1 regulators led to the identification of chromane derivatives that inhibit its proton conductance.	Chromans	68-76	uncoupling protein 1	Homo sapiens	23-27
21196229-5	2011	UCP1 uncouples adenosine-5"-triphosphate (ATP) synthesis from substrate oxidation in brown adipocytes.	Adenosine Triphosphate	42-45	uncoupling protein 1	Homo sapiens	0-4
20811644-8	2010	The flavonoid activates PPAR response element (PPRE) while suppressing LXRalpha response element (LXRE) in human hepatocytes, translating into the induction of PPAR-regulated fatty acid oxidation genes such as CYP4A11, ACOX, UCP1 and ApoAI, and inhibition of LXRalpha-regulated lipogenesis genes, such as FAS, ABCA1, ABCG1, and HMGR.	Flavonoids	4-13	uncoupling protein 1	Homo sapiens	225-229
21047682-6	2010	Alignment of the IML2 sequences revealed that UCP1, UCP2 and UCP3 share a basic amino acid in positions 163, 164 and 167, while only UCP2 and UCP3 contain a second basic residue in positions 168 and 171, respectively.	Amino Acids, Basic	74-90	uncoupling protein 1	Homo sapiens	46-50
21151149-2	2010	Its thermogenic potential is conferred by uncoupling protein-1, which "uncouples" adenosine triphosphate synthesis from energy substrate oxidation.	Adenosine Triphosphate	82-104	uncoupling protein 1	Homo sapiens	42-62
20935665-3	2010	BAT thermogenesis is triggered by the release of norepinephrine from its sympathetic nerve terminals, stimulating beta3-adrenoceptors that turns on a cascade of intracellular events ending in activation of uncoupling protein-1 (UCP-1).	Norepinephrine	49-63	uncoupling protein 1	Homo sapiens	206-233
20935665-4	2010	BAT also has sensory innervation that may function to monitor BAT lipolysis, a response necessary for activation of UCP-1 by fatty acids, or perhaps responding in a feedback manner to BAT temperature changes.	Fatty Acids	125-136	uncoupling protein 1	Homo sapiens	116-121
20935666-8	2010	UCP1 is an inner mitochondrial membrane protein that short circuits the mitochondrial proton gradient, so that oxygen consumption is no longer coupled to adenosine triphosphate synthesis.	Oxygen	111-117	uncoupling protein 1	Homo sapiens	0-4
20935666-8	2010	UCP1 is an inner mitochondrial membrane protein that short circuits the mitochondrial proton gradient, so that oxygen consumption is no longer coupled to adenosine triphosphate synthesis.	Adenosine Triphosphate	154-176	uncoupling protein 1	Homo sapiens	0-4
20811644-8	2010	The flavonoid activates PPAR response element (PPRE) while suppressing LXRalpha response element (LXRE) in human hepatocytes, translating into the induction of PPAR-regulated fatty acid oxidation genes such as CYP4A11, ACOX, UCP1 and ApoAI, and inhibition of LXRalpha-regulated lipogenesis genes, such as FAS, ABCA1, ABCG1, and HMGR.	Fatty Acids	175-185	uncoupling protein 1	Homo sapiens	225-229
20026010-3	2010	In the mitochondria of these organisms, UCP activity is revealed upon FFA-induced, PN-inhibited stimulation of resting respiration and a decrease in membrane potential, which are accompanied by a decrease in membranous ubiquinone (Q) reduction level.	Purine Nucleotides	83-85	uncoupling protein 1	Homo sapiens	40-43
20026010-3	2010	In the mitochondria of these organisms, UCP activity is revealed upon FFA-induced, PN-inhibited stimulation of resting respiration and a decrease in membrane potential, which are accompanied by a decrease in membranous ubiquinone (Q) reduction level.	Ubiquinone	219-229	uncoupling protein 1	Homo sapiens	40-43
20026010-6	2010	The action of reduced Q (QH2) could allow higher or complete activation of UCP.	q (qh2)	22-29	uncoupling protein 1	Homo sapiens	75-78
20388489-6	2010	Unlike the other members of the mitochondrial carrier superfamily, the eutherian uncoupling protein UCP1 has evolved to achieve its heat-generating capacity in the physiological context provided by the brown adipocyte and therefore it is activated by the low fatty acid concentrations generated by the noradrenaline-stimulated lipolysis.	Fatty Acids	259-269	uncoupling protein 1	Homo sapiens	100-104
20026010-8	2010	Here, we discuss the functional connection and physiological role of UCP and alternative oxidase, two main energy-dissipating systems in the plant-type mitochondrial respiratory chain of unicellular eukaryotes, including the control of cellular energy balance as well as preventive action against the production of reactive oxygen species.	Reactive Oxygen Species	315-338	uncoupling protein 1	Homo sapiens	69-72
20211596-1	2010	Uncoupling proteins (UCP1, UCP2 and UCP3) are important in regulating cellular fuel metabolism and as attenuators of reactive oxygen species production through strong or mild uncoupling.	Reactive Oxygen Species	117-140	uncoupling protein 1	Homo sapiens	21-25
20388489-6	2010	Unlike the other members of the mitochondrial carrier superfamily, the eutherian uncoupling protein UCP1 has evolved to achieve its heat-generating capacity in the physiological context provided by the brown adipocyte and therefore it is activated by the low fatty acid concentrations generated by the noradrenaline-stimulated lipolysis.	Norepinephrine	302-315	uncoupling protein 1	Homo sapiens	100-104
20399195-7	2010	Comparing basic medium composition, we find 125 mM sucrose optimal; an ionic medium (50-100 mM KCl) functions for wild-type but is detrimental for UCP1-/- mitochondria.	Potassium Chloride	95-98	uncoupling protein 1	Homo sapiens	147-151
20028987-2	2010	Examining precursors from the purest white adipose tissue depot (epididymal), we report here that chronic treatment with the peroxisome proliferator-activated receptor gamma agonist rosiglitazone promotes not only the expression of PGC-1alpha and mitochondriogenesis in these cells but also a norepinephrine-augmentable UCP1 gene expression in a significant subset of the cells, providing these cells with a genuine thermogenic capacity.	Rosiglitazone	182-195	uncoupling protein 1	Homo sapiens	320-324
20426850-9	2010	CONCLUSION: This work provides the first functional in vitro evidence that avian UCP regulates mitochondrial ROS production in situations of enhanced metabolic activity.	Reactive Oxygen Species	109-112	uncoupling protein 1	Homo sapiens	81-84
19444646-1	2010	Uncoupling protein 1 (UCP1), a 32-kDa protein located in the inner mitochondrial membrane, is abundant in brown adipose tissue, as a proton transporter in mitochondria inner membrane which uncouples oxidative metabolism from ATP synthesis and dissipates energy through the heat.	Adenosine Triphosphate	225-228	uncoupling protein 1	Homo sapiens	0-26
20388135-5	2010	Phytanic acid is an efficient inducer of the expression of uncoupler protein 1 (UCP1).	Phytanic Acid	0-13	uncoupling protein 1	Homo sapiens	80-84
20000716-6	2010	Interaction of reconstituted UCPs with GDP and GTP, inhibitors of the prototypic UCP1, was detected by near-UV CD and fluorescence spectroscopy, utilizing the sensitivity of these techniques to microenvironments around Trp residues close to the nucleotide binding site.	Guanosine Diphosphate	39-42	uncoupling protein 1	Homo sapiens	81-85
19816693-0	2010	Oxygen recovery up-regulates avian UCP and ANT in newly hatched ducklings.	Oxygen	0-6	uncoupling protein 1	Homo sapiens	35-38
20000716-6	2010	Interaction of reconstituted UCPs with GDP and GTP, inhibitors of the prototypic UCP1, was detected by near-UV CD and fluorescence spectroscopy, utilizing the sensitivity of these techniques to microenvironments around Trp residues close to the nucleotide binding site.	Guanosine Triphosphate	47-50	uncoupling protein 1	Homo sapiens	81-85
20000716-6	2010	Interaction of reconstituted UCPs with GDP and GTP, inhibitors of the prototypic UCP1, was detected by near-UV CD and fluorescence spectroscopy, utilizing the sensitivity of these techniques to microenvironments around Trp residues close to the nucleotide binding site.	Tryptophan	219-222	uncoupling protein 1	Homo sapiens	81-85
20338842-5	2010	Most notably, it captures the nonlinear rise in the proton leak rate at high membrane potential and the increase in this leak due to uncoupling protein (UCP) activation by ROS.	Reactive Oxygen Species	172-175	uncoupling protein 1	Homo sapiens	153-156
20338842-8	2010	Results suggest increasing mitochondrial density while decreasing UCP activity may be an effective way to increase glucose-stimulated insulin secretion while decreasing oxidative stress.	Glucose	115-122	uncoupling protein 1	Homo sapiens	66-69
19952371-4	2009	Furthermore, PKGI mediated the ability of nitric oxide (NO) and guanosine 3",5"-monophosphate (cGMP) to induce mitochondrial biogenesis and increase the abundance of UCP-1.	Nitric Oxide	42-54	uncoupling protein 1	Homo sapiens	166-171
19969105-3	2010	BAT cells can "burn" fatty acid energy substrates to generate heat because they possess large numbers of mitochondria in which oxidative phosphorylation is uncoupled from ATP production as a result of a transmembrane proton leak mediated by uncoupling protein 1 (UCP1).	Fatty Acids	21-31	uncoupling protein 1	Homo sapiens	241-261
19969105-3	2010	BAT cells can "burn" fatty acid energy substrates to generate heat because they possess large numbers of mitochondria in which oxidative phosphorylation is uncoupled from ATP production as a result of a transmembrane proton leak mediated by uncoupling protein 1 (UCP1).	Fatty Acids	21-31	uncoupling protein 1	Homo sapiens	263-267
19952371-4	2009	Furthermore, PKGI mediated the ability of nitric oxide (NO) and guanosine 3",5"-monophosphate (cGMP) to induce mitochondrial biogenesis and increase the abundance of UCP-1.	Cyclic GMP	64-93	uncoupling protein 1	Homo sapiens	166-171
19952371-4	2009	Furthermore, PKGI mediated the ability of nitric oxide (NO) and guanosine 3",5"-monophosphate (cGMP) to induce mitochondrial biogenesis and increase the abundance of UCP-1.	Cyclic GMP	95-99	uncoupling protein 1	Homo sapiens	166-171
19836315-1	2009	We describe here the development of a high-performance liquid chromatography (HPLC) method for quantitative determination of the ratio of isomers I and III of urinary coproporphyrin [the UCP I/(I+III) ratio], which is used for the diagnosis of Dubin-Johnson syndrome (DJS).	Coproporphyrins	167-181	uncoupling protein 1	Homo sapiens	187-190
19966534-0	2009	Low-calorie diet-induced reduction in serum HDL cholesterol is ameliorated in obese women with the -3826 G allele in the uncoupling protein-1 gene.	Cholesterol	48-59	uncoupling protein 1	Homo sapiens	121-141
18780286-4	2008	Hepatocyte or epidermal growth factor (EGF), or phorbol 12-myristate 13-acetate induced UCP expression following early induction of Egr-1 expression in HeLa cells.	Tetradecanoylphorbol Acetate	48-79	uncoupling protein 1	Homo sapiens	88-91
19556617-5	2009	In the retrospective study 103 non-diabetic patients showed a similar relationship between maximum glucose and UCP genotype (AA 6.8 (2.3) mmol/l; GA 7.8 (2.2) mmol/l; GG 9.2 (2.9) mmol/l; p = 0.0078).	Glucose	99-106	uncoupling protein 1	Homo sapiens	111-114
19539604-12	2009	Different from AAC the similarly structured uncoupling protein (UCP1) has no tightly bound CL, but CL addition lowers affinity of the inhibitory nucleotide binding that may contribute to the physiological regulation of the uncoupling activity by ATP.	Adenosine Triphosphate	246-249	uncoupling protein 1	Homo sapiens	64-68
19239631-4	2009	It increases expression of the uncoupling factor UCP1 and thereby causes a large stimulation of uncoupled respiration with resultant heat production, enhanced by cAMP.	Cyclic AMP	162-166	uncoupling protein 1	Homo sapiens	49-53
19753307-7	2009	Conversely, expression of the mitochondrial uncoupling protein 1 (UCP1) increased oxygen consumption and decreased tumor growth.	Oxygen	82-88	uncoupling protein 1	Homo sapiens	66-70
19746157-2	2009	In vivo and in vitro observations have correlated mitochondrial uncoupling protein-1 (UCP1) expression with reduced white adipose tissue triglyceride (TG) content.	Triglycerides	137-149	uncoupling protein 1	Homo sapiens	86-90
19746157-2	2009	In vivo and in vitro observations have correlated mitochondrial uncoupling protein-1 (UCP1) expression with reduced white adipose tissue triglyceride (TG) content.	Triglycerides	151-153	uncoupling protein 1	Homo sapiens	86-90
20403746-5	2009	UCP5 from oysters appears to be a close homolog of the mammalian brain mitochondrial carrier protein (BMCP1, or UCP5) and is the first full-length UCP described from a Lophotrochozoan invertebrate.	lophotrochozoan	168-183	uncoupling protein 1	Homo sapiens	0-3
19128480-2	2009	UCP1 is responsible for uncoupling mitochondrial proton transport from the production of ATP, thereby dissipating heat; it is essential for non-shivering thermogenesis (NST) in mammalian BAT.	Adenosine Triphosphate	89-92	uncoupling protein 1	Homo sapiens	0-4
18728005-8	2008	Oxygen consumption studies support a specific defect in proton leak due to attenuated uncoupling protein 1 expression.	Oxygen	0-6	uncoupling protein 1	Homo sapiens	86-106
18617684-4	2008	These cells can be expanded in culture, and their UCP1 mRNA expression is strongly increased by cell-permeating cAMP derivatives and a peroxisome-proliferator-activated receptor-gamma (PPARgamma) agonist.	Cyclic AMP	112-116	uncoupling protein 1	Homo sapiens	50-54
18195045-4	2008	Here we show the unexpected role of liver X receptor alpha (LXRalpha) as a direct transcriptional inhibitor of beta-adrenergic receptor-mediated, cyclic AMP-dependent Ucp1 gene expression through its binding to the critical enhancer region of the Ucp1 promoter.	Cyclic AMP	146-156	uncoupling protein 1	Homo sapiens	167-171
18287225-7	2008	The increased expression of UCP1 is likely an adaptive response to LTH, assuring adequate thermogenesis in the event of birth under oxygen-limiting conditions.	Oxygen	132-138	uncoupling protein 1	Homo sapiens	28-32
18305572-5	2008	The effects of norepinephrine (NE) and 9-cis retinoic acid (RA) on UCP expression were also investigated.	Alitretinoin	39-58	uncoupling protein 1	Homo sapiens	67-70
18305572-5	2008	The effects of norepinephrine (NE) and 9-cis retinoic acid (RA) on UCP expression were also investigated.	Tretinoin	60-62	uncoupling protein 1	Homo sapiens	67-70
18305572-7	2008	UCP1 expression in keratinocytes was synergistically upregulated by NE and RA treatment.	Tretinoin	75-77	uncoupling protein 1	Homo sapiens	0-4
18195045-4	2008	Here we show the unexpected role of liver X receptor alpha (LXRalpha) as a direct transcriptional inhibitor of beta-adrenergic receptor-mediated, cyclic AMP-dependent Ucp1 gene expression through its binding to the critical enhancer region of the Ucp1 promoter.	Cyclic AMP	146-156	uncoupling protein 1	Homo sapiens	247-251
18059613-5	2007	Fatty acids are also well recognized as activators of the prototypic UCP1 in brown adipose tissue.	Fatty Acids	0-11	uncoupling protein 1	Homo sapiens	69-73
18061577-2	2007	We have recently shown that expression of UCP1 in 3T3-L1 white adipocytes reduces the accumulation of triglycerides.	Triglycerides	102-115	uncoupling protein 1	Homo sapiens	42-46
17980348-5	2007	Interestingly, Cys28 substitution reduced ATP inhibitory effect on AtUCP1, while Tyr269Phe mutant exhibited 2.8-fold increase in sensitivity to ATP, in accordance with the reverse mutation Phe267Tyr of mammalian UCP1.	Adenosine Triphosphate	42-45	uncoupling protein 1	Homo sapiens	69-73
17676792-4	2007	These large temperature dependences below TC can be explained by the increase in polymer concentration in the uncrystallized phase C(p,UCP) with decreasing temperature.	Technetium	42-44	uncoupling protein 1	Homo sapiens	135-138
18850162-0	2007	UCP1 mRNA induction by RU486 in brown adipocytes is followed by marked induction of UCP1 protein levels.	Mifepristone	23-28	uncoupling protein 1	Homo sapiens	0-4
17576568-7	2007	This fatty acid sensitive proton leak is likely due to the expression of UCP1 in the liver of WA carp.	Fatty Acids	5-15	uncoupling protein 1	Homo sapiens	73-77
17452060-4	2007	Here we demonstrate that hyperglycemia-induced production of ROS is abrogated by inhibitors of mitochondrial metabolism, or by overexpression of uncoupling protein-1 or manganese superoxide dismutase.	Reactive Oxygen Species	61-64	uncoupling protein 1	Homo sapiens	145-165
17459509-7	2007	Mean 24-h UCP levels increased significantly from a baseline to at 36 months in the insulin sensitizers (IS) only group, in the IS plus sulfonylurea combination group and in IS plus insulin combination group (p&lt;0.001), whereas in the sulfonylurea only group, we could not find statistically significant changes (p=0.152).	Sulfonylurea Compounds	237-249	uncoupling protein 1	Homo sapiens	10-13
17459509-10	2007	Especially, IS plus sulfonylurea combination group resulted in greatest increase of 24-h UCP (DeltaC-peptide=51.19 microg/24h).	Sulfonylurea Compounds	20-32	uncoupling protein 1	Homo sapiens	89-92
17459509-11	2007	CONCLUSIONS: This study suggested that IS, in mono- or in combination, significantly improved pancreatic beta-cell function, especially when combined with sulfonylurea as evidenced by the increase of 24-h UCP.	Sulfonylurea Compounds	155-167	uncoupling protein 1	Homo sapiens	205-208
17909695-2	2007	Mitochondrial respiration may be uncoupled from ATP synthesis by a proton leak induced by the thermogenic uncoupling protein 1 (UCP1).	Adenosine Triphosphate	48-51	uncoupling protein 1	Homo sapiens	128-132
17676792-4	2007	These large temperature dependences below TC can be explained by the increase in polymer concentration in the uncrystallized phase C(p,UCP) with decreasing temperature.	Polymers	81-88	uncoupling protein 1	Homo sapiens	135-138
24351450-9	2007	During cold exposure, total power of the HRV, an index of the overall ANS activity, as well as the salivary cortisol concentration significantly increased in the children with homozygous (GG) for the UCP1 polymorphism while only cortisol response was found in the carriers of the wild-type (AA) and heterozygous (AG) alleles; however, the GG allele group showed a lower cold-induced thermogenesis compared to the AA + AG group.	Hydrocortisone	108-116	uncoupling protein 1	Homo sapiens	200-204
17584843-4	2007	While mitochondrial ROS generation may be important for regulation of mitochondrial uncoupling protein (UCP) activity and thus disruption of cellular energy metabolism, the NADPH oxidase associated ROS may alter parameters of signal transduction, insulin secretion, insulin action and cell proliferation or cell death.	Reactive Oxygen Species	20-23	uncoupling protein 1	Homo sapiens	104-107
18183781-4	2007	The discovery of mitochondrial uncoupling proteins (UCPs) opened a new field of investigation, emphasizing the role of UCP1 or thermogenin, which generates an energy dissipation as heat and diminishing the amount of formed ATP and ROS and forcing the cell that expresses the UCP1 to oxidize more nutrients to obtain energy.	Adenosine Triphosphate	223-226	uncoupling protein 1	Homo sapiens	119-123
18183781-4	2007	The discovery of mitochondrial uncoupling proteins (UCPs) opened a new field of investigation, emphasizing the role of UCP1 or thermogenin, which generates an energy dissipation as heat and diminishing the amount of formed ATP and ROS and forcing the cell that expresses the UCP1 to oxidize more nutrients to obtain energy.	Adenosine Triphosphate	223-226	uncoupling protein 1	Homo sapiens	127-138
18183781-4	2007	The discovery of mitochondrial uncoupling proteins (UCPs) opened a new field of investigation, emphasizing the role of UCP1 or thermogenin, which generates an energy dissipation as heat and diminishing the amount of formed ATP and ROS and forcing the cell that expresses the UCP1 to oxidize more nutrients to obtain energy.	ros	231-234	uncoupling protein 1	Homo sapiens	119-123
18183781-4	2007	The discovery of mitochondrial uncoupling proteins (UCPs) opened a new field of investigation, emphasizing the role of UCP1 or thermogenin, which generates an energy dissipation as heat and diminishing the amount of formed ATP and ROS and forcing the cell that expresses the UCP1 to oxidize more nutrients to obtain energy.	ros	231-234	uncoupling protein 1	Homo sapiens	127-138
17531095-5	2007	Ways in which PPARs may reduce oxidative stress involve modulation of mitochondrial uncoupling protein (UCP) expression (thus reducing reactive oxygen species, ROS), optimising forkhead box class O factor (FOXO) activity (by improving whole body insulin sensitivity) and suppressing NFkB (at the transcriptional level).	Reactive Oxygen Species	135-158	uncoupling protein 1	Homo sapiens	104-107
17531095-5	2007	Ways in which PPARs may reduce oxidative stress involve modulation of mitochondrial uncoupling protein (UCP) expression (thus reducing reactive oxygen species, ROS), optimising forkhead box class O factor (FOXO) activity (by improving whole body insulin sensitivity) and suppressing NFkB (at the transcriptional level).	Reactive Oxygen Species	160-163	uncoupling protein 1	Homo sapiens	104-107
17466497-5	2007	UCP-1 expression in aortic smooth muscle cells causes hypertension, enhanced superoxide anion production and decreased the availability of NO, suggesting that inefficient metabolism in blood vessels causes atherosclerosis without affecting cholesterol levels.	Superoxides	77-93	uncoupling protein 1	Homo sapiens	0-5
17466497-5	2007	UCP-1 expression in aortic smooth muscle cells causes hypertension, enhanced superoxide anion production and decreased the availability of NO, suggesting that inefficient metabolism in blood vessels causes atherosclerosis without affecting cholesterol levels.	Cholesterol	240-251	uncoupling protein 1	Homo sapiens	0-5
17381975-2	2007	The aim of this study was to analyse whether alterations in uncoupling protein (UCP) expression in white and brown adipose tissues (WAT and BAT, respectively) and in skeletal muscle may be responsible for the effect of trans-10, cis-12 CLA on the size of body fat depots in hamsters.	trans-10,cis-12-conjugated linoleic acid	219-239	uncoupling protein 1	Homo sapiens	80-83
24351450-9	2007	During cold exposure, total power of the HRV, an index of the overall ANS activity, as well as the salivary cortisol concentration significantly increased in the children with homozygous (GG) for the UCP1 polymorphism while only cortisol response was found in the carriers of the wild-type (AA) and heterozygous (AG) alleles; however, the GG allele group showed a lower cold-induced thermogenesis compared to the AA + AG group.	Hydrocortisone	229-237	uncoupling protein 1	Homo sapiens	200-204
17242157-0	2007	Polyunsaturated fatty acids activate human uncoupling proteins 1 and 2 in planar lipid bilayers.	Fatty Acids, Unsaturated	0-27	uncoupling protein 1	Homo sapiens	43-70
17242157-9	2007	The higher uncoupling protein (UCP)-dependent conductance in the presence of polyunsaturated FA is explained on the basis of the FA cycling hypothesis.	Fatty Acids, Unsaturated	77-95	uncoupling protein 1	Homo sapiens	31-34
17355127-7	2007	We took the mitochondrial uncoupling protein 1 (UCP1) as a model and showed that differential acetonitrile extraction of tryptic peptides combined with the use of polystirene Bio-Beads triggered high resolution of the MALDI-TOF identification of mitochondrial membrane proteins solubilized either with Triton-X100 or CHAPS detergents.	acetonitrile	94-106	uncoupling protein 1	Homo sapiens	48-52
17355127-7	2007	We took the mitochondrial uncoupling protein 1 (UCP1) as a model and showed that differential acetonitrile extraction of tryptic peptides combined with the use of polystirene Bio-Beads triggered high resolution of the MALDI-TOF identification of mitochondrial membrane proteins solubilized either with Triton-X100 or CHAPS detergents.	Peptides	129-137	uncoupling protein 1	Homo sapiens	48-52
17355127-7	2007	We took the mitochondrial uncoupling protein 1 (UCP1) as a model and showed that differential acetonitrile extraction of tryptic peptides combined with the use of polystirene Bio-Beads triggered high resolution of the MALDI-TOF identification of mitochondrial membrane proteins solubilized either with Triton-X100 or CHAPS detergents.	polystirene	163-174	uncoupling protein 1	Homo sapiens	48-52
17355127-7	2007	We took the mitochondrial uncoupling protein 1 (UCP1) as a model and showed that differential acetonitrile extraction of tryptic peptides combined with the use of polystirene Bio-Beads triggered high resolution of the MALDI-TOF identification of mitochondrial membrane proteins solubilized either with Triton-X100 or CHAPS detergents.	Octoxynol	302-313	uncoupling protein 1	Homo sapiens	48-52
17184177-2	2007	In endothelial cells, high-glucose treatment increases mitochondrial ROS and normalization of the ROS production by inhibitors of mitochondrial metabolism, or by overexpression of UCP-1 or MnSOD, prevents glucose-induced activation of PKC, formation of AGE, and accumulation of sorbitol, all of which are believed to be the main molecular mechanisms of diabetic complications.	Glucose	27-34	uncoupling protein 1	Homo sapiens	180-185
17397545-0	2007	The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study.	Glucose	121-128	uncoupling protein 1	Homo sapiens	4-24
17397545-0	2007	The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study.	Glucose	121-128	uncoupling protein 1	Homo sapiens	31-35
17184177-2	2007	In endothelial cells, high-glucose treatment increases mitochondrial ROS and normalization of the ROS production by inhibitors of mitochondrial metabolism, or by overexpression of UCP-1 or MnSOD, prevents glucose-induced activation of PKC, formation of AGE, and accumulation of sorbitol, all of which are believed to be the main molecular mechanisms of diabetic complications.	Glucose	205-212	uncoupling protein 1	Homo sapiens	180-185
17184177-2	2007	In endothelial cells, high-glucose treatment increases mitochondrial ROS and normalization of the ROS production by inhibitors of mitochondrial metabolism, or by overexpression of UCP-1 or MnSOD, prevents glucose-induced activation of PKC, formation of AGE, and accumulation of sorbitol, all of which are believed to be the main molecular mechanisms of diabetic complications.	Sorbitol	278-286	uncoupling protein 1	Homo sapiens	180-185
16860276-5	2006	Identification of mitochondrial uncoupling proteins UCP allowed further understanding of the mechanism of coupling or uncoupling of respiration to ADP phosphorylation.	Adenosine Diphosphate	147-150	uncoupling protein 1	Homo sapiens	52-55
16814247-0	2006	Fatty acid activation of the uncoupling proteins requires the presence of the central matrix loop from UCP1.	Fatty Acids	0-10	uncoupling protein 1	Homo sapiens	103-107
16814247-1	2006	Noradrenaline signals the initiation of brown fat thermogenesis and the fatty acids liberated by the hormone-stimulated lipolysis act as second messengers to activate the uncoupling protein UCP1.	Norepinephrine	0-13	uncoupling protein 1	Homo sapiens	190-194
16814247-1	2006	Noradrenaline signals the initiation of brown fat thermogenesis and the fatty acids liberated by the hormone-stimulated lipolysis act as second messengers to activate the uncoupling protein UCP1.	Fatty Acids	72-83	uncoupling protein 1	Homo sapiens	190-194
16814247-3	2006	The high affinity of UCP1 for fatty acids is a distinct feature of this uncoupling protein.	Fatty Acids	30-41	uncoupling protein 1	Homo sapiens	21-25
16814247-6	2006	Using protein chimeras, where the repeats had been swapped between UCP1 and UCP3, it has been shown that the central third of UCP1 is necessary and sufficient for the response of the protein to fatty acids.	Fatty Acids	194-205	uncoupling protein 1	Homo sapiens	67-71
16814247-6	2006	Using protein chimeras, where the repeats had been swapped between UCP1 and UCP3, it has been shown that the central third of UCP1 is necessary and sufficient for the response of the protein to fatty acids.	Fatty Acids	194-205	uncoupling protein 1	Homo sapiens	126-130
16814247-9	2006	We demonstrate that the presence of the second matrix loop is necessary for the high affinity activation of UCP1 by fatty acids.	Fatty Acids	116-127	uncoupling protein 1	Homo sapiens	108-112
16954335-7	2007	Finally, testosterone inhibited the transcription of pgc1alpha, the master factor involved in UCP1 expression and mitochondrial biogenesis.	Testosterone	9-21	uncoupling protein 1	Homo sapiens	94-98
16451125-0	2006	Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria.	Fatty Acids	11-21	uncoupling protein 1	Homo sapiens	84-104
16697409-3	2006	The mammalian uncoupling protein UCP1 is activated by fatty acids and inhibited by nucleotides.	Fatty Acids	54-65	uncoupling protein 1	Homo sapiens	33-37
16603126-5	2006	ZmPUMP was also used to investigate the importance of a histidine pair present in the second matrix loop of mammalian UCP1 and absent in plant UCPs.	Histidine	56-65	uncoupling protein 1	Homo sapiens	118-122
16626624-9	2006	We demonstrate that hUCP1 activity in the presence of fatty acids is comparable to the activity of UCP1 isolated from brown adipose tissue.	Fatty Acids	54-65	uncoupling protein 1	Homo sapiens	20-25
16626624-9	2006	We demonstrate that hUCP1 activity in the presence of fatty acids is comparable to the activity of UCP1 isolated from brown adipose tissue.	Fatty Acids	54-65	uncoupling protein 1	Homo sapiens	21-25
16806053-4	2006	Here we examine critically the evidence that UCP1, UCP2 and UCP3 are stimulated by ROS (superoxide) or ROS products (4-hydroxy-2-nonenal), and that the UCPs actually diminish oxidative damage.	Reactive Oxygen Species	83-86	uncoupling protein 1	Homo sapiens	45-49
16806053-4	2006	Here we examine critically the evidence that UCP1, UCP2 and UCP3 are stimulated by ROS (superoxide) or ROS products (4-hydroxy-2-nonenal), and that the UCPs actually diminish oxidative damage.	Superoxides	88-98	uncoupling protein 1	Homo sapiens	45-49
16806053-4	2006	Here we examine critically the evidence that UCP1, UCP2 and UCP3 are stimulated by ROS (superoxide) or ROS products (4-hydroxy-2-nonenal), and that the UCPs actually diminish oxidative damage.	Reactive Oxygen Species	103-106	uncoupling protein 1	Homo sapiens	45-49
16806053-4	2006	Here we examine critically the evidence that UCP1, UCP2 and UCP3 are stimulated by ROS (superoxide) or ROS products (4-hydroxy-2-nonenal), and that the UCPs actually diminish oxidative damage.	4-hydroxy-2-nonenal	117-136	uncoupling protein 1	Homo sapiens	45-49
16772444-7	2006	UCP excretion was associated with the GL after adjustment for body weight, protein, and fiber intake [mean UCP (95% CI) in GL tertiles 1-3: 6.19 (5.37, 7.14) vs. 7.82 (6.77, 9.02) vs. 7.76 (6.71, 8.97) nmol/d, P for difference 0.04].	glycylleucine	38-40	uncoupling protein 1	Homo sapiens	0-3
16772444-7	2006	UCP excretion was associated with the GL after adjustment for body weight, protein, and fiber intake [mean UCP (95% CI) in GL tertiles 1-3: 6.19 (5.37, 7.14) vs. 7.82 (6.77, 9.02) vs. 7.76 (6.71, 8.97) nmol/d, P for difference 0.04].	glycylleucine	123-125	uncoupling protein 1	Homo sapiens	0-3
16772444-7	2006	UCP excretion was associated with the GL after adjustment for body weight, protein, and fiber intake [mean UCP (95% CI) in GL tertiles 1-3: 6.19 (5.37, 7.14) vs. 7.82 (6.77, 9.02) vs. 7.76 (6.71, 8.97) nmol/d, P for difference 0.04].	glycylleucine	123-125	uncoupling protein 1	Homo sapiens	107-110
16772444-10	2006	The observed positive relation of UCP with GL appears to result largely from its association with the amount of CHO, whereas dietary GI may be relevant only at higher intake levels.	glycylleucine	43-45	uncoupling protein 1	Homo sapiens	34-37
16772444-10	2006	The observed positive relation of UCP with GL appears to result largely from its association with the amount of CHO, whereas dietary GI may be relevant only at higher intake levels.	CAV protocol	112-115	uncoupling protein 1	Homo sapiens	34-37
16707280-2	2006	Since mitochondrial electron transport is a major source of free radical production, it is possible that UCP activity might impact free radical production.	Free Radicals	60-72	uncoupling protein 1	Homo sapiens	105-108
16707280-2	2006	Since mitochondrial electron transport is a major source of free radical production, it is possible that UCP activity might impact free radical production.	Free Radicals	131-143	uncoupling protein 1	Homo sapiens	105-108
16707280-5	2006	If UCP function were to impact mitochondrial free radical production, then one would expect to find a link between UCP activity and aging.	Free Radicals	45-57	uncoupling protein 1	Homo sapiens	3-6
16707280-5	2006	If UCP function were to impact mitochondrial free radical production, then one would expect to find a link between UCP activity and aging.	Free Radicals	45-57	uncoupling protein 1	Homo sapiens	115-118
16730638-3	2006	In addition, we review the two proposed mechanisms for fatty acid dependent UCP 1 activity, namely (a) the flippase (flip-flop) model and (b) the cofactor/activation model, and the implication for these models of recent data showing that glucose-O-omega-palmitate cannot facilitate UCP 1 activity.	Fatty Acids	55-65	uncoupling protein 1	Homo sapiens	76-81
16730638-3	2006	In addition, we review the two proposed mechanisms for fatty acid dependent UCP 1 activity, namely (a) the flippase (flip-flop) model and (b) the cofactor/activation model, and the implication for these models of recent data showing that glucose-O-omega-palmitate cannot facilitate UCP 1 activity.	Fatty Acids	55-65	uncoupling protein 1	Homo sapiens	282-287
16730638-3	2006	In addition, we review the two proposed mechanisms for fatty acid dependent UCP 1 activity, namely (a) the flippase (flip-flop) model and (b) the cofactor/activation model, and the implication for these models of recent data showing that glucose-O-omega-palmitate cannot facilitate UCP 1 activity.	glucose-o-omega-palmitate	238-263	uncoupling protein 1	Homo sapiens	76-81
16730638-3	2006	In addition, we review the two proposed mechanisms for fatty acid dependent UCP 1 activity, namely (a) the flippase (flip-flop) model and (b) the cofactor/activation model, and the implication for these models of recent data showing that glucose-O-omega-palmitate cannot facilitate UCP 1 activity.	glucose-o-omega-palmitate	238-263	uncoupling protein 1	Homo sapiens	282-287
16451125-0	2006	Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria.	alkenal	35-42	uncoupling protein 1	Homo sapiens	84-104
16451125-4	2006	Activation of the proton conductance of UCP1 was synergistic: proton conductance in the presence of both palmitate and 4-HNE was significantly greater than the sum of the individual effects.	Palmitates	105-114	uncoupling protein 1	Homo sapiens	40-44
16451125-4	2006	Activation of the proton conductance of UCP1 was synergistic: proton conductance in the presence of both palmitate and 4-HNE was significantly greater than the sum of the individual effects.	4-hydroxy-2-nonenal	119-124	uncoupling protein 1	Homo sapiens	40-44
16451125-8	2006	These results show that reactive alkenals activate the proton conductance of UCP1 more strongly when fatty acids are also added, with implications for both mechanistic and physiological models of UCP1 activation.	alkenals	33-41	uncoupling protein 1	Homo sapiens	77-81
16451125-8	2006	These results show that reactive alkenals activate the proton conductance of UCP1 more strongly when fatty acids are also added, with implications for both mechanistic and physiological models of UCP1 activation.	alkenals	33-41	uncoupling protein 1	Homo sapiens	196-200
16451125-8	2006	These results show that reactive alkenals activate the proton conductance of UCP1 more strongly when fatty acids are also added, with implications for both mechanistic and physiological models of UCP1 activation.	Fatty Acids	101-112	uncoupling protein 1	Homo sapiens	77-81
16451125-8	2006	These results show that reactive alkenals activate the proton conductance of UCP1 more strongly when fatty acids are also added, with implications for both mechanistic and physiological models of UCP1 activation.	Fatty Acids	101-112	uncoupling protein 1	Homo sapiens	196-200
16766382-6	2006	Recent findings have shown an increase in uncoupling protein (UCP) activity with lower ROS levels, after CR stress.	Reactive Oxygen Species	87-90	uncoupling protein 1	Homo sapiens	62-65
16644673-4	2006	Using reduced MitoTracker Red probe, we confirmed that TNF-alpha increased mitochondrial ROS production, which was suppressed by overexpression of either uncoupling protein-1 (UCP)-1 or manganese superoxide dismutase (MnSOD).	Reactive Oxygen Species	89-92	uncoupling protein 1	Homo sapiens	154-182
16766382-9	2006	Thus, the decreased ROS production seen in both CR and longer lifespan may occur via up-regulation of free fatty acid stimulation of UCP activity.	Reactive Oxygen Species	20-23	uncoupling protein 1	Homo sapiens	133-136
16766382-9	2006	Thus, the decreased ROS production seen in both CR and longer lifespan may occur via up-regulation of free fatty acid stimulation of UCP activity.	Fatty Acids, Nonesterified	102-117	uncoupling protein 1	Homo sapiens	133-136
16034720-0	2005	Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes.	Aldosterone	0-11	uncoupling protein 1	Homo sapiens	21-41
16026418-11	2005	UCP 1 with other uncoupling proteins may have other functions in the control of body weight, sugar balance and formation of reactive oxygen species.	Sugars	93-98	uncoupling protein 1	Homo sapiens	0-5
16026418-11	2005	UCP 1 with other uncoupling proteins may have other functions in the control of body weight, sugar balance and formation of reactive oxygen species.	Reactive Oxygen Species	124-147	uncoupling protein 1	Homo sapiens	0-5
16641553-2	2006	In these cells, UCP1 acts as a proton carrier activated by free fatty acids and creates a shunt between complexes of the respiratory chain and ATP-synthase resulting in a futile proton cycling and dissipation of oxidation energy as heat.	Fatty Acids, Nonesterified	59-75	uncoupling protein 1	Homo sapiens	16-20
16641553-3	2006	Recent identification of new homologues to UCP1 expressed in brown and white adipose tissue, muscle, brain and other tissues together with the hypothesis that these novel uncoupling proteins (UCPs) may regulate thermogenesis and/or fatty acid metabolism and furthermore may protect against free radical oxygen species production have generated considerable optimism for rapid advances in the identification of new targets for pharmacological management of complex pathological syndromes such as obesity, type 2 diabetes or chronic inflammatory diseases.	Fatty Acids	232-242	uncoupling protein 1	Homo sapiens	43-47
16641553-3	2006	Recent identification of new homologues to UCP1 expressed in brown and white adipose tissue, muscle, brain and other tissues together with the hypothesis that these novel uncoupling proteins (UCPs) may regulate thermogenesis and/or fatty acid metabolism and furthermore may protect against free radical oxygen species production have generated considerable optimism for rapid advances in the identification of new targets for pharmacological management of complex pathological syndromes such as obesity, type 2 diabetes or chronic inflammatory diseases.	free radical oxygen	290-309	uncoupling protein 1	Homo sapiens	43-47
16034720-5	2005	Aldosterone dose-dependently inhibited expression of uncoupling protein-1 (UCP-1) by 30% (p &lt; 0.01).	Aldosterone	0-11	uncoupling protein 1	Homo sapiens	53-80
15964803-0	2005	Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.	Cyclic AMP	113-123	uncoupling protein 1	Homo sapiens	134-138
15964803-1	2005	The sympathetic nervous system regulates the activity and expression of uncoupling protein 1 (UCP1) through the three beta-adrenergic receptor subtypes and their ability to raise intracellular cyclic AMP (cAMP) levels.	Cyclic AMP	193-203	uncoupling protein 1	Homo sapiens	72-92
15964803-1	2005	The sympathetic nervous system regulates the activity and expression of uncoupling protein 1 (UCP1) through the three beta-adrenergic receptor subtypes and their ability to raise intracellular cyclic AMP (cAMP) levels.	Cyclic AMP	193-203	uncoupling protein 1	Homo sapiens	94-98
15964803-1	2005	The sympathetic nervous system regulates the activity and expression of uncoupling protein 1 (UCP1) through the three beta-adrenergic receptor subtypes and their ability to raise intracellular cyclic AMP (cAMP) levels.	Cyclic AMP	205-209	uncoupling protein 1	Homo sapiens	72-92
15964803-1	2005	The sympathetic nervous system regulates the activity and expression of uncoupling protein 1 (UCP1) through the three beta-adrenergic receptor subtypes and their ability to raise intracellular cyclic AMP (cAMP) levels.	Cyclic AMP	205-209	uncoupling protein 1	Homo sapiens	94-98
15964803-2	2005	Unexpectedly, we recently discovered that the cAMP-dependent regulation of multiple genes in brown adipocytes, including Ucp1, occurred through the p38 mitogen-activated protein kinases (MAPK) (W. Cao, K. W. Daniel, J. Robidoux, P. Puigserver, A. V. Medvedev, X. Bai, L. M. Floering, B. M. Spiegelman, and S. Collins, Mol.	Cyclic AMP	46-50	uncoupling protein 1	Homo sapiens	121-125
16180337-0	2005	Ectopic UCP1 gene expression in HepG2 cells affects ATP production.	Adenosine Triphosphate	52-55	uncoupling protein 1	Homo sapiens	8-12
16180337-3	2005	Therefore, the purpose of this experiment was to achieve an ectopic expression of UCP1 in HepG2 cells to significantly decrease the production of ATP.	Adenosine Triphosphate	146-149	uncoupling protein 1	Homo sapiens	82-86
16180337-4	2005	The UCP1 gene was transferred into the hepatic cells by using a calcium phosphate precipitation protocol.	calcium phosphate	64-81	uncoupling protein 1	Homo sapiens	4-8
16180337-7	2005	Transfected liver cells with UCP1 showed a decrease of 23% in ATP production in comparison with control cells without expression of UCP1 (2.23 vs. 2.90 RLU/pg protein, p=0.015).	Adenosine Triphosphate	62-65	uncoupling protein 1	Homo sapiens	29-33
16180337-8	2005	In conclusion, the ectopic expression of UCP1 decreased the production of ATP, possibly uncoupling the oxidative phosphorylation, which could be a novel approach for understanding thermogenic processes and eventually for energy metabolism and body weight management.	Adenosine Triphosphate	74-77	uncoupling protein 1	Homo sapiens	41-45
15757659-3	2005	Although lithium reduces the expression of genes common to both white and brown adipocytes [fatty acid binding protein aP2 (aP2/FABP) or peroxisome proliferating activated receptor gamma], genes expressed differentially in brown adipocytes, i.e., uncoupling protein 1, PPAR gamma coactivator-1alpha, and peroxisome proliferating activated receptor alpha, are particularly sensitive to lithium treatment-dependent downregulation.	Lithium	9-16	uncoupling protein 1	Homo sapiens	247-267
15888413-5	2005	We show that avian UCP protects yeast mitochondria against the deleterious impact of ROS, but without stimulation of superoxide dismutase activity.	Reactive Oxygen Species	85-88	uncoupling protein 1	Homo sapiens	19-22
15888413-6	2005	Avian UCP protein was specifically immunodetected and retinoic acid, which belongs to the carotenoid family, was found to trigger its activity.	Tretinoin	54-67	uncoupling protein 1	Homo sapiens	6-9
15888413-6	2005	Avian UCP protein was specifically immunodetected and retinoic acid, which belongs to the carotenoid family, was found to trigger its activity.	Carotenoids	90-100	uncoupling protein 1	Homo sapiens	6-9
15888413-7	2005	These data show that avian UCP basal activity protects against ROS damage.	Reactive Oxygen Species	63-66	uncoupling protein 1	Homo sapiens	27-30
15888413-8	2005	However, when activated by retinoic acid, avian UCP can also operate as the mammalian thermogenic UCP1.	Tretinoin	27-40	uncoupling protein 1	Homo sapiens	48-51
15888413-8	2005	However, when activated by retinoic acid, avian UCP can also operate as the mammalian thermogenic UCP1.	Tretinoin	27-40	uncoupling protein 1	Homo sapiens	98-102
15525551-1	2004	It is widely acknowledged that the function of the original uncoupling protein, UCP1, is uncoupling of substrate oxidation from ATP synthesis, and that its physiological purpose is thermogenesis.	Adenosine Triphosphate	128-131	uncoupling protein 1	Homo sapiens	80-84
15654920-10	2005	Furthermore, brown adipocytes are also target cells for rosiglitazone action since they show a high expression of peroxisome proliferator activated receptor gamma, and rosiglitazone increased the expression of the thermogenic uncoupling protein 1.	Rosiglitazone	56-69	uncoupling protein 1	Homo sapiens	226-246
15654920-10	2005	Furthermore, brown adipocytes are also target cells for rosiglitazone action since they show a high expression of peroxisome proliferator activated receptor gamma, and rosiglitazone increased the expression of the thermogenic uncoupling protein 1.	Rosiglitazone	168-181	uncoupling protein 1	Homo sapiens	226-246
16038477-10	2005	Stavudine caused a specific induction of UCP1 gene expression through direct interaction with a retinoic acid-dependent pathway.	Stavudine	0-9	uncoupling protein 1	Homo sapiens	41-45
16038477-10	2005	Stavudine caused a specific induction of UCP1 gene expression through direct interaction with a retinoic acid-dependent pathway.	Tretinoin	96-109	uncoupling protein 1	Homo sapiens	41-45
16075814-5	2005	UCP1 is only expressed in BAT through the synergistic action of norepinephrine (NE) and thyroid hormones in animals exposed to cold and to a lesser degree after meals.	Norepinephrine	64-78	uncoupling protein 1	Homo sapiens	0-4
15242813-3	2004	We did not identify an inhibition at the level of the adrenergic receptors, but a first site of inhibition was identified as the generation of cAMP by adenylyl cyclase; this led to inhibition of norepinephrine-induced expression of the uncoupling protein-1 (UCP1) gene and reduced norepinephrine-induced lipolysis as secondary effects.	Cyclic AMP	143-147	uncoupling protein 1	Homo sapiens	236-262
15313455-4	2004	Sympathetic nerve endings release noradrenaline (NA) in the proximity of brown fat cells, where noradrenaline activates G-protein-coupled beta-adrenergic receptors (AR) and by doing so initiates a cascade of metabolic events culminating in the activation of uncoupling protein 1 (UCP1).	Norepinephrine	34-47	uncoupling protein 1	Homo sapiens	258-278
15313455-4	2004	Sympathetic nerve endings release noradrenaline (NA) in the proximity of brown fat cells, where noradrenaline activates G-protein-coupled beta-adrenergic receptors (AR) and by doing so initiates a cascade of metabolic events culminating in the activation of uncoupling protein 1 (UCP1).	Norepinephrine	34-47	uncoupling protein 1	Homo sapiens	280-284
15313455-4	2004	Sympathetic nerve endings release noradrenaline (NA) in the proximity of brown fat cells, where noradrenaline activates G-protein-coupled beta-adrenergic receptors (AR) and by doing so initiates a cascade of metabolic events culminating in the activation of uncoupling protein 1 (UCP1).	Norepinephrine	96-109	uncoupling protein 1	Homo sapiens	258-278
15313455-4	2004	Sympathetic nerve endings release noradrenaline (NA) in the proximity of brown fat cells, where noradrenaline activates G-protein-coupled beta-adrenergic receptors (AR) and by doing so initiates a cascade of metabolic events culminating in the activation of uncoupling protein 1 (UCP1).	Norepinephrine	96-109	uncoupling protein 1	Homo sapiens	280-284
15313455-6	2004	It is found in the inner membrane of the mitochondrion, where uncoupling protein 1 uncouples the oxidation of fuel from adenosine triphosphate (ATP) production.	Adenosine Triphosphate	120-142	uncoupling protein 1	Homo sapiens	62-82
15338309-0	2004	The steroid RU486 induces UCP1 expression in brown adipocytes.	Steroids	4-11	uncoupling protein 1	Homo sapiens	26-30
15338309-0	2004	The steroid RU486 induces UCP1 expression in brown adipocytes.	Mifepristone	12-17	uncoupling protein 1	Homo sapiens	26-30
15338309-5	2004	In culture-grown, differentiated brown adipocytes, placed in a serum-free medium to exclude the presence of progesterone or glucocorticoids, RU486 stimulated UCP1 expression at both the mRNA and protein levels.	Mifepristone	141-146	uncoupling protein 1	Homo sapiens	158-162
15313455-6	2004	It is found in the inner membrane of the mitochondrion, where uncoupling protein 1 uncouples the oxidation of fuel from adenosine triphosphate (ATP) production.	Adenosine Triphosphate	144-147	uncoupling protein 1	Homo sapiens	62-82
15334664-5	2004	However, it caused a GDP-inhibition of state 4 respiration and a GDP-induced re-polarization of the inner mitochondrial membrane in the presence of fatty acids, in agreement with its expected physiological behavior as an uncoupling protein (UCP).	Guanosine Diphosphate	21-24	uncoupling protein 1	Homo sapiens	241-244
15334664-5	2004	However, it caused a GDP-inhibition of state 4 respiration and a GDP-induced re-polarization of the inner mitochondrial membrane in the presence of fatty acids, in agreement with its expected physiological behavior as an uncoupling protein (UCP).	Guanosine Diphosphate	65-68	uncoupling protein 1	Homo sapiens	241-244
15334664-5	2004	However, it caused a GDP-inhibition of state 4 respiration and a GDP-induced re-polarization of the inner mitochondrial membrane in the presence of fatty acids, in agreement with its expected physiological behavior as an uncoupling protein (UCP).	Fatty Acids	148-159	uncoupling protein 1	Homo sapiens	241-244
15242813-3	2004	We did not identify an inhibition at the level of the adrenergic receptors, but a first site of inhibition was identified as the generation of cAMP by adenylyl cyclase; this led to inhibition of norepinephrine-induced expression of the uncoupling protein-1 (UCP1) gene and reduced norepinephrine-induced lipolysis as secondary effects.	Norepinephrine	195-209	uncoupling protein 1	Homo sapiens	236-262
16120384-3	2004	In this context, the role of uncoupling proteins (UCPs) in modulating resting energy expenditure in response to elevated fatty acid flux associated with the "metabolic syndrome" is supported by clinical data as well as findings of elevated adipose tissue UCP expression.	Fatty Acids	121-131	uncoupling protein 1	Homo sapiens	50-53
15281018-11	2004	These results suggest that the GG type of the UCP-1 gene has a strong association with increased LDL cholesterol level and might be a significant risk factor for hyper-LDL cholesterolemia among Korean obese subjects.	Cholesterol	101-112	uncoupling protein 1	Homo sapiens	46-51
15274694-0	2004	Relationship between the in vitro-estimated utilizable crude protein and the Cornell Net Carbohydrate and Protein System crude protein fractions in feeds for ruminants.	Carbohydrates	89-101	uncoupling protein 1	Homo sapiens	44-68
15274694-1	2004	The objectives of this experiment were to study the regression relationship between the in vitro-estimated utilizable crude protein (uCP) and the Cornell Net Carbohydrate and Protein System (CNCPS) crude protein fractions, i.e. PA, PB1, PB2, PB3 and PC of feeds for ruminants, and the possibility of using CNCPS crude protein fractions for the estimation of uCP of feeds for ruminants.	Carbohydrates	158-170	uncoupling protein 1	Homo sapiens	107-131
15274694-1	2004	The objectives of this experiment were to study the regression relationship between the in vitro-estimated utilizable crude protein (uCP) and the Cornell Net Carbohydrate and Protein System (CNCPS) crude protein fractions, i.e. PA, PB1, PB2, PB3 and PC of feeds for ruminants, and the possibility of using CNCPS crude protein fractions for the estimation of uCP of feeds for ruminants.	Carbohydrates	158-170	uncoupling protein 1	Homo sapiens	133-136
15274694-4	2004	It was found that there was a significant multiple regression relationship between the uCP [g/kg dry matter (DM)] and the CNCPS crude protein fractions, i.e. PA (% DM), PB1 (% DM), PB2 (% DM), PB3 (% DM) and PC (% DM) of the feed samples.	Protactinium	158-160	uncoupling protein 1	Homo sapiens	87-90
15274694-4	2004	It was found that there was a significant multiple regression relationship between the uCP [g/kg dry matter (DM)] and the CNCPS crude protein fractions, i.e. PA (% DM), PB1 (% DM), PB2 (% DM), PB3 (% DM) and PC (% DM) of the feed samples.	dm	109-111	uncoupling protein 1	Homo sapiens	87-90
15274694-4	2004	It was found that there was a significant multiple regression relationship between the uCP [g/kg dry matter (DM)] and the CNCPS crude protein fractions, i.e. PA (% DM), PB1 (% DM), PB2 (% DM), PB3 (% DM) and PC (% DM) of the feed samples.	dm	164-166	uncoupling protein 1	Homo sapiens	87-90
15274694-4	2004	It was found that there was a significant multiple regression relationship between the uCP [g/kg dry matter (DM)] and the CNCPS crude protein fractions, i.e. PA (% DM), PB1 (% DM), PB2 (% DM), PB3 (% DM) and PC (% DM) of the feed samples.	dm	164-166	uncoupling protein 1	Homo sapiens	87-90
15274694-4	2004	It was found that there was a significant multiple regression relationship between the uCP [g/kg dry matter (DM)] and the CNCPS crude protein fractions, i.e. PA (% DM), PB1 (% DM), PB2 (% DM), PB3 (% DM) and PC (% DM) of the feed samples.	CHEMBL511942	193-196	uncoupling protein 1	Homo sapiens	87-90
15274694-4	2004	It was found that there was a significant multiple regression relationship between the uCP [g/kg dry matter (DM)] and the CNCPS crude protein fractions, i.e. PA (% DM), PB1 (% DM), PB2 (% DM), PB3 (% DM) and PC (% DM) of the feed samples.	dm	164-166	uncoupling protein 1	Homo sapiens	87-90
15274694-4	2004	It was found that there was a significant multiple regression relationship between the uCP [g/kg dry matter (DM)] and the CNCPS crude protein fractions, i.e. PA (% DM), PB1 (% DM), PB2 (% DM), PB3 (% DM) and PC (% DM) of the feed samples.	pc	208-210	uncoupling protein 1	Homo sapiens	87-90
15274694-4	2004	It was found that there was a significant multiple regression relationship between the uCP [g/kg dry matter (DM)] and the CNCPS crude protein fractions, i.e. PA (% DM), PB1 (% DM), PB2 (% DM), PB3 (% DM) and PC (% DM) of the feed samples.	dm	164-166	uncoupling protein 1	Homo sapiens	87-90
15274694-5	2004	uCP = (9.95 +/-2.73)PA + (2.92 +/- 1.36)PB(1) + (7.24 +/- 0.86)PB(2) + (8.20 +/- 3.33)PB(3) + (17.67 +/- 3.79) PC + (63.26 +/- 18.02), r2 = 0.90, n = 30, p &lt; 0.0001.	Protactinium	20-24	uncoupling protein 1	Homo sapiens	0-3
15274694-5	2004	uCP = (9.95 +/-2.73)PA + (2.92 +/- 1.36)PB(1) + (7.24 +/- 0.86)PB(2) + (8.20 +/- 3.33)PB(3) + (17.67 +/- 3.79) PC + (63.26 +/- 18.02), r2 = 0.90, n = 30, p &lt; 0.0001.	Lead	40-42	uncoupling protein 1	Homo sapiens	0-3
15274694-5	2004	uCP = (9.95 +/-2.73)PA + (2.92 +/- 1.36)PB(1) + (7.24 +/- 0.86)PB(2) + (8.20 +/- 3.33)PB(3) + (17.67 +/- 3.79) PC + (63.26 +/- 18.02), r2 = 0.90, n = 30, p &lt; 0.0001.	3.33)pb(3) +	81-93	uncoupling protein 1	Homo sapiens	0-3
14749278-5	2004	In these cells, UCP1 acts as a proton carrier activated by free fatty acids and creates a shunt between complexes of the respiratory chain and ATP synthase.	Fatty Acids, Nonesterified	59-75	uncoupling protein 1	Homo sapiens	16-20
15294045-11	2004	High-fat diets, which increase the mitochondrial supply of fatty acids, also up regulate UCP.	Fatty Acids	59-70	uncoupling protein 1	Homo sapiens	89-92
14871489-0	2004	Alkylsulfonates activate the uncoupling protein UCP1: implications for the transport mechanism.	Alkanesulfonates	0-15	uncoupling protein 1	Homo sapiens	48-52
14871489-1	2004	Fatty acids activate the uncoupling protein UCP1 by a still controversial mechanism.	Fatty Acids	0-11	uncoupling protein 1	Homo sapiens	44-48
14871489-4	2004	We show that undecanosulfonate activates UCP1 in respiring mitochondria under conditions identical to those required for the activation by fatty acids.	undecanosulfonate	13-30	uncoupling protein 1	Homo sapiens	41-45
14871489-4	2004	We show that undecanosulfonate activates UCP1 in respiring mitochondria under conditions identical to those required for the activation by fatty acids.	Fatty Acids	139-150	uncoupling protein 1	Homo sapiens	41-45
14871489-8	2004	The high activity observed in the absence of the two regulatory ligands is an indication that UCP1 displays an intrinsic proton conductance that is fatty acid-independent.	Fatty Acids	148-158	uncoupling protein 1	Homo sapiens	94-98
14871489-9	2004	We propose that the fatty acid uncoupling mediated by other members of the mitochondrial transporter family probably involves a carrier to pore transition and therefore has little in common with the activation of UCP1.	Fatty Acids	20-30	uncoupling protein 1	Homo sapiens	213-217
14749278-9	2004	In comparison to the established uncoupling and thermogenic activities of UCP1, UCP2 and UCP3 appear to be involved in the limitation of free radical levels in cells rather than in physiological uncoupling and thermogenesis.	Free Radicals	137-149	uncoupling protein 1	Homo sapiens	74-78
14518702-7	2003	Zidovudine-based HAART recipients (n=7) also displayed significant mtDNA depletion (34.45% of control, P=0.031), increased mitochondrial protein mass (5.7-fold of control, P=0.009), and markedly increased UCP1 (18-fold of control, P=0.009) mRNA.	Zidovudine	0-10	uncoupling protein 1	Homo sapiens	205-209
14758565-8	2004	It has now been shown to influence the abundance of UCP1 in the fetus, a role that may in part be regulated by the metabolically active thyroid hormone triiodothyronine.	Triiodothyronine	152-168	uncoupling protein 1	Homo sapiens	52-56
14514642-4	2003	Similarly, incubation of HMCs with 30 mmol/l glucose significantly increased mitochondrial membrane potential, intracellular ROS production, COX-2 protein expression, and PGE2 synthesis, and these events were completely suppressed by thenoyltrifluoroacetone or carbonyl cyanide m-chlorophenylhydrazone, inhibitors of mitochondrial metabolism, or by overexpression of uncoupling protein-1 or manganese superoxide dismutase.	Glucose	45-52	uncoupling protein 1	Homo sapiens	367-387
14514642-4	2003	Similarly, incubation of HMCs with 30 mmol/l glucose significantly increased mitochondrial membrane potential, intracellular ROS production, COX-2 protein expression, and PGE2 synthesis, and these events were completely suppressed by thenoyltrifluoroacetone or carbonyl cyanide m-chlorophenylhydrazone, inhibitors of mitochondrial metabolism, or by overexpression of uncoupling protein-1 or manganese superoxide dismutase.	Thenoyltrifluoroacetone	234-257	uncoupling protein 1	Homo sapiens	367-387
14514642-4	2003	Similarly, incubation of HMCs with 30 mmol/l glucose significantly increased mitochondrial membrane potential, intracellular ROS production, COX-2 protein expression, and PGE2 synthesis, and these events were completely suppressed by thenoyltrifluoroacetone or carbonyl cyanide m-chlorophenylhydrazone, inhibitors of mitochondrial metabolism, or by overexpression of uncoupling protein-1 or manganese superoxide dismutase.	Carbonyl Cyanide m-Chlorophenyl Hydrazone	261-301	uncoupling protein 1	Homo sapiens	367-387
12826670-2	2003	According to alternative hypotheses, mitochondrial uncoupling protein 1 (UCP1) is either a proton channel ("buffering model") or a fatty acid anion carrier ("fatty acid cycling").	Fatty Acids	131-141	uncoupling protein 1	Homo sapiens	73-77
12826670-2	2003	According to alternative hypotheses, mitochondrial uncoupling protein 1 (UCP1) is either a proton channel ("buffering model") or a fatty acid anion carrier ("fatty acid cycling").	Fatty Acids	157-168	uncoupling protein 1	Homo sapiens	73-77
12826670-4	2003	In this work, we demonstrate that planar bilayers reconstituted with UCP1 exhibit an increase in membrane conductivity exclusively in the presence of fatty acids.	Fatty Acids	150-161	uncoupling protein 1	Homo sapiens	69-73
12826670-7	2003	Direct application of transmembrane voltage and precise current measurements allowed determination of ATP-sensitive conductances at 0 and 150 mV as 11.5 and 54.3 pS, respectively, by reconstituting nearly 3 x 10(5) copies of UCP1.	Adenosine Triphosphate	102-105	uncoupling protein 1	Homo sapiens	225-229
14523556-3	2003	TRIAC is 10-50 times more potent than T3 at increasing the adrenergic induction of UCP-1 mRNA and D2 activities.	3,3',5-triiodothyroacetic acid	0-5	uncoupling protein 1	Homo sapiens	83-88
14523556-4	2003	TRIAC action on UCP-1 is exerted at the transcriptional level.	3,3',5-triiodothyroacetic acid	0-5	uncoupling protein 1	Homo sapiens	16-21
12807871-10	2003	The PPAR gamma agonist rosiglitazone potentiated the effect of PGC-1 alpha on UCP1 expression and fatty acid oxidation.	Rosiglitazone	23-36	uncoupling protein 1	Homo sapiens	78-82
14518702-8	2003	Elevated UCP1 mRNA expression was found to be associated with non-stavudine (zidovudine or abacavir), protease inhibitor (PI)-containing HAART (95-fold of non-stavudine, non-PI-containing HAART, P=0.006).	Stavudine	66-75	uncoupling protein 1	Homo sapiens	9-13
14518702-8	2003	Elevated UCP1 mRNA expression was found to be associated with non-stavudine (zidovudine or abacavir), protease inhibitor (PI)-containing HAART (95-fold of non-stavudine, non-PI-containing HAART, P=0.006).	Zidovudine	77-87	uncoupling protein 1	Homo sapiens	9-13
14518702-8	2003	Elevated UCP1 mRNA expression was found to be associated with non-stavudine (zidovudine or abacavir), protease inhibitor (PI)-containing HAART (95-fold of non-stavudine, non-PI-containing HAART, P=0.006).	abacavir	91-99	uncoupling protein 1	Homo sapiens	9-13
14518702-8	2003	Elevated UCP1 mRNA expression was found to be associated with non-stavudine (zidovudine or abacavir), protease inhibitor (PI)-containing HAART (95-fold of non-stavudine, non-PI-containing HAART, P=0.006).	Stavudine	159-168	uncoupling protein 1	Homo sapiens	9-13
14518702-10	2003	Increased UCP1 mRNA, a marker of brown adipose tissue phenotype, was associated with non-stavudine, PI-containing HAART, and may represent an adaptive response to the increased fatty acid flux associated with PI therapy, and may contribute to the increased resting energy expenditure reported in such patients.	Stavudine	89-98	uncoupling protein 1	Homo sapiens	10-14
14518702-10	2003	Increased UCP1 mRNA, a marker of brown adipose tissue phenotype, was associated with non-stavudine, PI-containing HAART, and may represent an adaptive response to the increased fatty acid flux associated with PI therapy, and may contribute to the increased resting energy expenditure reported in such patients.	Fatty Acids	177-187	uncoupling protein 1	Homo sapiens	10-14
14692599-5	2003	UCP3 is, like UCP1, able to uncouple respiration from ATP production.	Adenosine Triphosphate	54-57	uncoupling protein 1	Homo sapiens	14-18
12734183-0	2003	Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10.	Adenosine Triphosphate	96-99	uncoupling protein 1	Homo sapiens	51-67
12734183-3	2003	We show for the first time that ATP inhibits UCP1, -2, and -3 with similar affinities.	Adenosine Triphosphate	32-35	uncoupling protein 1	Homo sapiens	45-49
12734183-4	2003	The Ki values for ATP inhibition were 50 microm (UCP1), 70 microm (UCP2), and 120 microm (UCP3) at pH 7.2.	Adenosine Triphosphate	18-21	uncoupling protein 1	Homo sapiens	49-53
12734183-5	2003	These affinities for ATP are similar to those obtained with native UCP1 isolated from brown adipose tissue mitochondria (Ki = 65 microm at pH 7.2).	Adenosine Triphosphate	21-24	uncoupling protein 1	Homo sapiens	67-71
12753942-7	2003	CONCLUSIONS: The -3826 A-G polymorphism of the UCP1 gene is associated with an increase in BW of premenopausal women and with the 4-year changes in serum triglyceride and high-density lipoprotein levels in postmenopausal women.	Triglycerides	154-166	uncoupling protein 1	Homo sapiens	47-51
12839995-3	2003	In contrast, providing RAS2(val19) cells with the mammalian uncoupling protein UCP1 restores phosphorylating respiration and reduces ROS levels, but does not correct for PKA-dependent defects.	Reactive Oxygen Species	133-136	uncoupling protein 1	Homo sapiens	79-83
12951617-3	2003	The polymorphism -3826 A/G of the UCP1 alone or in conjunction with the mutation Trp64Arg of the adrenergic receptor b3 has been associated with obesity, diabetes mellitus and related diseases although with contradictory results.	trp64arg	81-89	uncoupling protein 1	Homo sapiens	34-38
12678439-1	2002	The uncoupling protein from brown adipose tissue (UCP1) is a mitochondrial proton transporter whose activity is inhibited by purine nucleotides.	Purine Nucleotides	125-143	uncoupling protein 1	Homo sapiens	50-54
12740453-12	2003	DISCUSSION: The strong correlation of UCP expression and decrease in IMTG levels suggests that triglyceride content plays an even more important role in the regulation of UCP gene expression than the circulating levels of free fatty acids or the achieved degree of weight loss.	Triglycerides	95-107	uncoupling protein 1	Homo sapiens	38-41
12740453-12	2003	DISCUSSION: The strong correlation of UCP expression and decrease in IMTG levels suggests that triglyceride content plays an even more important role in the regulation of UCP gene expression than the circulating levels of free fatty acids or the achieved degree of weight loss.	Triglycerides	95-107	uncoupling protein 1	Homo sapiens	171-174
12479871-0	2003	Substitutional mutations in the uncoupling protein-specific sequences of mitochondrial uncoupling protein UCP1 lead to the reduction of fatty acid-induced H+ uniport.	Fatty Acids	136-146	uncoupling protein 1	Homo sapiens	106-110
12479871-3	2003	The wild type UCP1 was associated with the FA-induced H+ uniport proportional to the added protein with a Km for lauric acid of 43 micro M and Vmax of 18 micro molmin(-1)(mg protein)(-1).	lauric acid	113-124	uncoupling protein 1	Homo sapiens	14-18
12733325-12	2002	My initial work helped to characterize a mitochondrial protein named uncoupling protein or UCP which is responsible for activation of fatty acid oxidation and heat production in brown adipocytes.	Fatty Acids	134-144	uncoupling protein 1	Homo sapiens	91-94
12646277-2	2003	The H(+) transport activity of UCP1 is activated by long-chain fatty acids and inhibited by purine nucleotides.	long-chain fatty acids	52-74	uncoupling protein 1	Homo sapiens	31-35
12646277-2	2003	The H(+) transport activity of UCP1 is activated by long-chain fatty acids and inhibited by purine nucleotides.	Purine Nucleotides	92-110	uncoupling protein 1	Homo sapiens	31-35
12646277-3	2003	While nucleotide binding has been well characterized, the interaction of fatty acid with UCP1 remains unknown.	Fatty Acids	73-83	uncoupling protein 1	Homo sapiens	89-93
12646277-5	2003	Fatty acids but not their esters competitively inhibit the binding of 2(")-O-dansyl GTP to UCP1.	Fatty Acids	0-11	uncoupling protein 1	Homo sapiens	91-95
12646277-5	2003	Fatty acids but not their esters competitively inhibit the binding of 2(")-O-dansyl GTP to UCP1.	2(")-o-dansyl gtp	70-87	uncoupling protein 1	Homo sapiens	91-95
12646277-6	2003	The fatty acid effect was enhanced at higher pH, suggesting the binding of fatty acid anion to UCP1.	Fatty Acids	4-14	uncoupling protein 1	Homo sapiens	95-99
12646277-6	2003	The fatty acid effect was enhanced at higher pH, suggesting the binding of fatty acid anion to UCP1.	fatty acid anion	75-91	uncoupling protein 1	Homo sapiens	95-99
12525862-5	2003	However, UCP-1 increases proton leakage across the inner membrane of brown adipocyte mitochondria and thereby dissipates proton motive force as heat instead of ATP synthesis.	Adenosine Triphosphate	160-163	uncoupling protein 1	Homo sapiens	9-14
12117300-7	2002	The half-life of UCP1 under basal conditions and in cells chronically exposed to NE was estimated from reductions in [35S]methionine-labelled immunoprecipitable UCP1 over 72 h. UCP1 t1/2 under basal conditions was 3.7+/-0.4 days, which was similar to the half-lives of labelled mitochondrial translation products (3.6+/-0.8 days).	Sulfur-35	118-121	uncoupling protein 1	Homo sapiens	17-21
12475182-0	2002	Opposite actions of testosterone and progesterone on UCP1 mRNA expression in cultured brown adipocytes.	Testosterone	20-32	uncoupling protein 1	Homo sapiens	53-57
12475182-0	2002	Opposite actions of testosterone and progesterone on UCP1 mRNA expression in cultured brown adipocytes.	Progesterone	37-49	uncoupling protein 1	Homo sapiens	53-57
12475182-2	2002	In the present work, we aimed to investigate the effects of the main physiological male and female sex hormones, i.e. testosterone, progesterone and 17-beta-estradiol, on the expression of uncoupling protein I (UCP1)--the main mediator of BAT thermogenesis--and on UCP2 and lipid accumulation in rodent brown adipocytes differentiated in culture.	Testosterone	118-130	uncoupling protein 1	Homo sapiens	211-215
12475182-2	2002	In the present work, we aimed to investigate the effects of the main physiological male and female sex hormones, i.e. testosterone, progesterone and 17-beta-estradiol, on the expression of uncoupling protein I (UCP1)--the main mediator of BAT thermogenesis--and on UCP2 and lipid accumulation in rodent brown adipocytes differentiated in culture.	Progesterone	132-144	uncoupling protein 1	Homo sapiens	211-215
12475182-2	2002	In the present work, we aimed to investigate the effects of the main physiological male and female sex hormones, i.e. testosterone, progesterone and 17-beta-estradiol, on the expression of uncoupling protein I (UCP1)--the main mediator of BAT thermogenesis--and on UCP2 and lipid accumulation in rodent brown adipocytes differentiated in culture.	Estradiol	149-166	uncoupling protein 1	Homo sapiens	211-215
12475182-3	2002	Testosterone-treated cells showed fewer and smaller lipid droplets than control cells and a dose-dependent inhibition of UCP1 mRNA expression, under adrenergic stimulation by norepinephrine (NE).	Testosterone	0-12	uncoupling protein 1	Homo sapiens	121-125
12475182-3	2002	Testosterone-treated cells showed fewer and smaller lipid droplets than control cells and a dose-dependent inhibition of UCP1 mRNA expression, under adrenergic stimulation by norepinephrine (NE).	Norepinephrine	175-189	uncoupling protein 1	Homo sapiens	121-125
12475182-5	2002	Progesterone- and 17-beta-estradiol-treated cells showed more and larger lipid droplets and progesterone stimulated NE-induced UCP1 mRNA expression at the lower concentration tested, but not at higher concentrations, suggesting that for brown adipocytes, this hormone is dose dependent.	Progesterone	0-12	uncoupling protein 1	Homo sapiens	127-131
12475182-5	2002	Progesterone- and 17-beta-estradiol-treated cells showed more and larger lipid droplets and progesterone stimulated NE-induced UCP1 mRNA expression at the lower concentration tested, but not at higher concentrations, suggesting that for brown adipocytes, this hormone is dose dependent.	Estradiol	18-35	uncoupling protein 1	Homo sapiens	127-131
12475182-5	2002	Progesterone- and 17-beta-estradiol-treated cells showed more and larger lipid droplets and progesterone stimulated NE-induced UCP1 mRNA expression at the lower concentration tested, but not at higher concentrations, suggesting that for brown adipocytes, this hormone is dose dependent.	Progesterone	92-104	uncoupling protein 1	Homo sapiens	127-131
12475182-7	2002	Interestingly, the specific progesterone receptor antagonist RU486 induced UCP1 and UCP2 mRNAs, including UCP1 mRNA expression in non-NE-treated brown adipocytes, suggesting a profound effect of this antiprogestagen on brown adipocyte thermogenic capacity.	Mifepristone	61-66	uncoupling protein 1	Homo sapiens	75-79
12475182-7	2002	Interestingly, the specific progesterone receptor antagonist RU486 induced UCP1 and UCP2 mRNAs, including UCP1 mRNA expression in non-NE-treated brown adipocytes, suggesting a profound effect of this antiprogestagen on brown adipocyte thermogenic capacity.	Mifepristone	61-66	uncoupling protein 1	Homo sapiens	106-110
12475182-8	2002	Thus, are conclude that testosterone, 17-beta-estradiol, progesterone and RU486 have distinct actions on brown adipocytes, thus modulating UCP1 and UCP2 mRNA expression and/or lipid accumulation, and that sex hormones are factors that may explain in part the gender-dependent BAT thermogenic response.	Testosterone	24-36	uncoupling protein 1	Homo sapiens	139-143
12475182-8	2002	Thus, are conclude that testosterone, 17-beta-estradiol, progesterone and RU486 have distinct actions on brown adipocytes, thus modulating UCP1 and UCP2 mRNA expression and/or lipid accumulation, and that sex hormones are factors that may explain in part the gender-dependent BAT thermogenic response.	Estradiol	38-55	uncoupling protein 1	Homo sapiens	139-143
12475182-8	2002	Thus, are conclude that testosterone, 17-beta-estradiol, progesterone and RU486 have distinct actions on brown adipocytes, thus modulating UCP1 and UCP2 mRNA expression and/or lipid accumulation, and that sex hormones are factors that may explain in part the gender-dependent BAT thermogenic response.	Progesterone	57-69	uncoupling protein 1	Homo sapiens	139-143
12475182-8	2002	Thus, are conclude that testosterone, 17-beta-estradiol, progesterone and RU486 have distinct actions on brown adipocytes, thus modulating UCP1 and UCP2 mRNA expression and/or lipid accumulation, and that sex hormones are factors that may explain in part the gender-dependent BAT thermogenic response.	Mifepristone	74-79	uncoupling protein 1	Homo sapiens	139-143
12044870-3	2002	Thus, the negative effect of TNF-alpha on UCP-1 mRNA expression at 4-5 h, under basal conditions or in cells treated with the PPAR gamma agonist, rosiglitazone, was reversed by the MEK1 inhibitor PD98059.	Rosiglitazone	146-159	uncoupling protein 1	Homo sapiens	42-47
12044870-3	2002	Thus, the negative effect of TNF-alpha on UCP-1 mRNA expression at 4-5 h, under basal conditions or in cells treated with the PPAR gamma agonist, rosiglitazone, was reversed by the MEK1 inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	196-203	uncoupling protein 1	Homo sapiens	42-47
12375271-4	2002	It has recently been demonstrated that the beta(3)-adrenergic receptor is the functionally relevant adrenergic receptor subtype in brown adipocytes and that its stimulation by noradrenaline (NA) modulates the expression of genes, such as uncoupling protein (UCP)-1 and inducible nitric oxide synthase (iNOS), involved in fat cell proliferation and differentiation.	Norepinephrine	176-189	uncoupling protein 1	Homo sapiens	238-264
12084707-8	2002	Transient transfection assay using luciferase reporter constructs also indicates that the two half-site CREs are involved in transcriptional regulation of Ucp1 in response to norepinephrine and cAMP.	Norepinephrine	175-189	uncoupling protein 1	Homo sapiens	155-159
12084707-8	2002	Transient transfection assay using luciferase reporter constructs also indicates that the two half-site CREs are involved in transcriptional regulation of Ucp1 in response to norepinephrine and cAMP.	Cyclic AMP	194-198	uncoupling protein 1	Homo sapiens	155-159
12084707-11	2002	Co-transfections with an Nfe2l2 expression vector and a luciferase reporter construct of the Ucp1 enhancer region provide additional evidence that Nfe2l2 is involved in the regulation of Ucp1 by cAMP-mediated signaling.	Cyclic AMP	195-199	uncoupling protein 1	Homo sapiens	93-97
12084707-11	2002	Co-transfections with an Nfe2l2 expression vector and a luciferase reporter construct of the Ucp1 enhancer region provide additional evidence that Nfe2l2 is involved in the regulation of Ucp1 by cAMP-mediated signaling.	Cyclic AMP	195-199	uncoupling protein 1	Homo sapiens	187-191
12208505-0	2002	Photoaffinity labeling of the uncoupling protein UCP1 with retinoic acid: ubiquinone favors binding.	Tretinoin	59-72	uncoupling protein 1	Homo sapiens	49-53
12208505-0	2002	Photoaffinity labeling of the uncoupling protein UCP1 with retinoic acid: ubiquinone favors binding.	Ubiquinone	74-84	uncoupling protein 1	Homo sapiens	49-53
12208505-1	2002	Retinoic acid is a potent activator of the uncoupling protein-1 (UCP1) both at the gene and mitochondrial level.	Tretinoin	0-13	uncoupling protein 1	Homo sapiens	43-69
12208505-4	2002	All-trans-retinoic acid binds to UCP1 with high affinity and the labeling is only partially protected by guanosine diphosphate.	Tretinoin	0-23	uncoupling protein 1	Homo sapiens	33-37
12208505-4	2002	All-trans-retinoic acid binds to UCP1 with high affinity and the labeling is only partially protected by guanosine diphosphate.	Guanosine Diphosphate	105-126	uncoupling protein 1	Homo sapiens	33-37
12208505-5	2002	Ubiquinone (UQ) has been described to be an obligatory cofactor for uncoupling protein function and we demonstrate that it greatly increases the affinity of UCP1 for retinoic acid.	Ubiquinone	0-10	uncoupling protein 1	Homo sapiens	157-161
12208505-5	2002	Ubiquinone (UQ) has been described to be an obligatory cofactor for uncoupling protein function and we demonstrate that it greatly increases the affinity of UCP1 for retinoic acid.	Ubiquinone	12-14	uncoupling protein 1	Homo sapiens	157-161
12208505-5	2002	Ubiquinone (UQ) has been described to be an obligatory cofactor for uncoupling protein function and we demonstrate that it greatly increases the affinity of UCP1 for retinoic acid.	Tretinoin	166-179	uncoupling protein 1	Homo sapiens	157-161
12010762-6	2002	Hence, on the one hand, trans-10, cis-12 inhibited uncoupling protein (UCP) 1 induction by norepinephrine (NE) and produced a decrease in leptin mRNA levels.	trans-10	24-32	uncoupling protein 1	Homo sapiens	51-77
12010762-6	2002	Hence, on the one hand, trans-10, cis-12 inhibited uncoupling protein (UCP) 1 induction by norepinephrine (NE) and produced a decrease in leptin mRNA levels.	cis-12	34-40	uncoupling protein 1	Homo sapiens	51-77
12010762-6	2002	Hence, on the one hand, trans-10, cis-12 inhibited uncoupling protein (UCP) 1 induction by norepinephrine (NE) and produced a decrease in leptin mRNA levels.	Norepinephrine	91-105	uncoupling protein 1	Homo sapiens	51-77
12010762-8	2002	On the other hand, cis-9, trans-11 enhanced the UCP1 elicited by NE, an effect reported earlier for polyunsaturated fatty acids and also observed here for linoleic acid.	cis-9	19-24	uncoupling protein 1	Homo sapiens	48-52
12010762-8	2002	On the other hand, cis-9, trans-11 enhanced the UCP1 elicited by NE, an effect reported earlier for polyunsaturated fatty acids and also observed here for linoleic acid.	trans-11	26-34	uncoupling protein 1	Homo sapiens	48-52
12010762-8	2002	On the other hand, cis-9, trans-11 enhanced the UCP1 elicited by NE, an effect reported earlier for polyunsaturated fatty acids and also observed here for linoleic acid.	Fatty Acids, Unsaturated	100-127	uncoupling protein 1	Homo sapiens	48-52
12010762-8	2002	On the other hand, cis-9, trans-11 enhanced the UCP1 elicited by NE, an effect reported earlier for polyunsaturated fatty acids and also observed here for linoleic acid.	Linoleic Acid	155-168	uncoupling protein 1	Homo sapiens	48-52
12010762-9	2002	These findings could explain, at least in part, the effects observed in vivo when feeding a CLA mixture supplemented diet as a result of the combined action of CLA isomers (reduction of adipogenesis and defective BAT thermogenesis that could be through trans-10, cis-12 and enhanced UCP1 thermogenic capacity through cis-9, trans-11).	Linoleic Acids, Conjugated	92-95	uncoupling protein 1	Homo sapiens	283-287
12010762-9	2002	These findings could explain, at least in part, the effects observed in vivo when feeding a CLA mixture supplemented diet as a result of the combined action of CLA isomers (reduction of adipogenesis and defective BAT thermogenesis that could be through trans-10, cis-12 and enhanced UCP1 thermogenic capacity through cis-9, trans-11).	Linoleic Acids, Conjugated	160-163	uncoupling protein 1	Homo sapiens	283-287
12117300-7	2002	The half-life of UCP1 under basal conditions and in cells chronically exposed to NE was estimated from reductions in [35S]methionine-labelled immunoprecipitable UCP1 over 72 h. UCP1 t1/2 under basal conditions was 3.7+/-0.4 days, which was similar to the half-lives of labelled mitochondrial translation products (3.6+/-0.8 days).	Methionine	122-132	uncoupling protein 1	Homo sapiens	17-21
12117300-7	2002	The half-life of UCP1 under basal conditions and in cells chronically exposed to NE was estimated from reductions in [35S]methionine-labelled immunoprecipitable UCP1 over 72 h. UCP1 t1/2 under basal conditions was 3.7+/-0.4 days, which was similar to the half-lives of labelled mitochondrial translation products (3.6+/-0.8 days).	Methionine	122-132	uncoupling protein 1	Homo sapiens	161-165
12117300-7	2002	The half-life of UCP1 under basal conditions and in cells chronically exposed to NE was estimated from reductions in [35S]methionine-labelled immunoprecipitable UCP1 over 72 h. UCP1 t1/2 under basal conditions was 3.7+/-0.4 days, which was similar to the half-lives of labelled mitochondrial translation products (3.6+/-0.8 days).	Methionine	122-132	uncoupling protein 1	Homo sapiens	161-165
12054495-1	2002	Until very recently, the uncoupling protein-1 (UCP1), present only in brown adipose tissue (BAT), was considered to be the only mitochondrial carrier protein that stimulated heat production by dissipating the proton gradient generated during respiration across the inner mitochondrial membrane and therefore uncoupling respiration from ATP synthesis.	Adenosine Triphosphate	336-339	uncoupling protein 1	Homo sapiens	25-45
12054495-1	2002	Until very recently, the uncoupling protein-1 (UCP1), present only in brown adipose tissue (BAT), was considered to be the only mitochondrial carrier protein that stimulated heat production by dissipating the proton gradient generated during respiration across the inner mitochondrial membrane and therefore uncoupling respiration from ATP synthesis.	Adenosine Triphosphate	336-339	uncoupling protein 1	Homo sapiens	47-51
11960973-4	2002	UCP1, found in the mitochondrial inner membrane in BAT, uncouples energy substrate oxidation from mitochondrial ATP production and hence results in the loss of potential energy as heat.	Adenosine Triphosphate	112-115	uncoupling protein 1	Homo sapiens	0-4
11875072-5	2002	As in rodents, PGC-1 is involved in the transcriptional regulation of the UCP1 gene in humans and mediates the effects of PPARalpha and PPARgamma agonists and retinoic acid.	Tretinoin	159-172	uncoupling protein 1	Homo sapiens	74-78
12032762-1	2002	Uncoupling protein 1 (UCP1) is uniquely expressed in brown adipose tissue (BAT) and generates heat by uncoupling respiration from ATP synthesis.	Adenosine Triphosphate	130-133	uncoupling protein 1	Homo sapiens	0-26
12032762-8	2002	However, transient transfection of a rodent brown adipocyte cell line shows that the isoproterenol (ISO) stimulation of the hUCP1 gene transcription is not significantly affected by this mutation.	Isoproterenol	85-98	uncoupling protein 1	Homo sapiens	124-129
12032762-8	2002	However, transient transfection of a rodent brown adipocyte cell line shows that the isoproterenol (ISO) stimulation of the hUCP1 gene transcription is not significantly affected by this mutation.	Isoproterenol	100-103	uncoupling protein 1	Homo sapiens	124-129
11709069-6	2001	Studies with intact brown adipocytes generated the currently accepted model, namely that fatty acids liberated by beta3-adrenergic receptor activation act as both self-regulating second messengers for UCP1 and substrates for fatty acid activation and oxidation.	Fatty Acids	89-100	uncoupling protein 1	Homo sapiens	201-205
11723122-4	2002	The relative molar expression of these subtypes was quantified through comparison with histidine-tagged UCP1 or UCP2 proteins engineered by expression in Escherichia coli.	Histidine	87-96	uncoupling protein 1	Homo sapiens	104-108
11723122-7	2002	These results were not due to nonspecific overexpression of mitochondrial protein since UCP1 activity was inhibited by GDP and because overexpression of another membrane carrier protein, the oxoglutarate malate carrier had no effect.	Guanosine Diphosphate	119-122	uncoupling protein 1	Homo sapiens	88-92
11742803-2	2002	Quiescent brown preadipocytes express high levels of UCP-1 mRNA in response to triiodothyronine (T3) and norepinephrine (NE).	Triiodothyronine	79-95	uncoupling protein 1	Homo sapiens	53-58
11742803-2	2002	Quiescent brown preadipocytes express high levels of UCP-1 mRNA in response to triiodothyronine (T3) and norepinephrine (NE).	Triiodothyronine	97-99	uncoupling protein 1	Homo sapiens	53-58
11742803-2	2002	Quiescent brown preadipocytes express high levels of UCP-1 mRNA in response to triiodothyronine (T3) and norepinephrine (NE).	Norepinephrine	105-119	uncoupling protein 1	Homo sapiens	53-58
11709069-6	2001	Studies with intact brown adipocytes generated the currently accepted model, namely that fatty acids liberated by beta3-adrenergic receptor activation act as both self-regulating second messengers for UCP1 and substrates for fatty acid activation and oxidation.	Fatty Acids	89-99	uncoupling protein 1	Homo sapiens	201-205
11709069-7	2001	Fatty acid concentration increases at the outset of thermogenesis, binding to UCP1 lowers the protonmotive force below that giving respiratory control and rapid thermogenesis proceeds.	Fatty Acids	0-10	uncoupling protein 1	Homo sapiens	78-82
11709075-1	2001	A role for uncoupling protein (UCP) 3 in fatty acid metabolism is reviewed within the context of our proposal, first put forward in 1998, that this homologue of UCP1 may be involved in the regulation of lipids as fuel substrate rather than in the mediation of thermogenesis.	Fatty Acids	41-51	uncoupling protein 1	Homo sapiens	161-165
11709078-1	2001	Two competing models of uncoupling protein (UCP) transport mechanism agree that fatty acids (FAs) are obligatory for uncoupling, but they disagree about which ion is transported.	Fatty Acids	80-91	uncoupling protein 1	Homo sapiens	44-47
11709078-1	2001	Two competing models of uncoupling protein (UCP) transport mechanism agree that fatty acids (FAs) are obligatory for uncoupling, but they disagree about which ion is transported.	Fatty Acids	93-96	uncoupling protein 1	Homo sapiens	44-47
11709078-4	2001	In the latter model, UCP transports the anionic FA head group from one side of the membrane to the other, and the cycle is completed by rapid flip-flop of protonated FAs across the bilayer.	Fatty Acids	166-169	uncoupling protein 1	Homo sapiens	21-24
11709078-5	2001	The head groups of the FA analogues, long-chain alkylsulphonates, are translocated by UCP, but they cannot induce uncoupling, because these strong acids cannot be protonated for the flip-flop part of the cycle.	long-chain alkylsulphonates	37-64	uncoupling protein 1	Homo sapiens	86-89
11729636-1	2001	Uncoupling protein (UCP) is a transporter family present in the mitochondrial inner membrane, and as its name suggests, it uncouples respiration from ATP synthesis by dissipating the transmembrane proton gradient as heat.	Adenosine Triphosphate	150-153	uncoupling protein 1	Homo sapiens	20-23
11696579-5	2001	Both the inhibition of eNOS and the changes in its post-translational modifications were reversed by antisense inhibition of glutamine:fructose-6-phosphate amidotransferase, the rate-limiting enzyme of the hexosamine pathway, or by blocking mitochondrial superoxide overproduction with uncoupling protein-1 (UCP-1) or manganese superoxide dismutase (MnSOD).	Glutamine	125-134	uncoupling protein 1	Homo sapiens	286-313
11696579-5	2001	Both the inhibition of eNOS and the changes in its post-translational modifications were reversed by antisense inhibition of glutamine:fructose-6-phosphate amidotransferase, the rate-limiting enzyme of the hexosamine pathway, or by blocking mitochondrial superoxide overproduction with uncoupling protein-1 (UCP-1) or manganese superoxide dismutase (MnSOD).	Hexosamines	206-216	uncoupling protein 1	Homo sapiens	286-313
11729636-4	2001	BAT thermogenesis by UCP-1, which has been studied most extensively, is controlled directly by sympathetic nerves principally through the beta-adrenergic action of norepinephrine.	Norepinephrine	164-178	uncoupling protein 1	Homo sapiens	21-26
11729636-8	2001	Long chain fatty acids and some of their metabolites are known to activate PPAR and thereby lead to abundant expression of UCP, which may also contribute to increase in energy expenditure and prevention of obesity.	long chain fatty acids	0-22	uncoupling protein 1	Homo sapiens	123-126
11729636-9	2001	The activity of UCP is suppressed by purine nucleotides but activated by fatty acids.	Purine Nucleotides	37-55	uncoupling protein 1	Homo sapiens	16-19
11729636-9	2001	The activity of UCP is suppressed by purine nucleotides but activated by fatty acids.	Fatty Acids	73-84	uncoupling protein 1	Homo sapiens	16-19
11729636-10	2001	Thus, fatty acids increase UCP-mediated thermogenesis by direct activation of UCP and also by increased gene expression, implying some specific fatty acids or their derivatives as an effective anti-obesity tool.	Fatty Acids	6-17	uncoupling protein 1	Homo sapiens	27-30
11729636-10	2001	Thus, fatty acids increase UCP-mediated thermogenesis by direct activation of UCP and also by increased gene expression, implying some specific fatty acids or their derivatives as an effective anti-obesity tool.	Fatty Acids	6-17	uncoupling protein 1	Homo sapiens	78-81
11729636-10	2001	Thus, fatty acids increase UCP-mediated thermogenesis by direct activation of UCP and also by increased gene expression, implying some specific fatty acids or their derivatives as an effective anti-obesity tool.	Fatty Acids	144-155	uncoupling protein 1	Homo sapiens	27-30
11798029-7	2001	UCP1 is regulated physiologically by fatty acids and purine nucleotides.	Fatty Acids	37-48	uncoupling protein 1	Homo sapiens	0-4
11798029-7	2001	UCP1 is regulated physiologically by fatty acids and purine nucleotides.	Purine Nucleotides	53-71	uncoupling protein 1	Homo sapiens	0-4
11798029-8	2001	Nucleotides maintain the proton conductance inhibited while fatty acids act as cytosolic second messengers of noradrenaline to active UCP1.	Fatty Acids	60-71	uncoupling protein 1	Homo sapiens	134-138
11798029-8	2001	Nucleotides maintain the proton conductance inhibited while fatty acids act as cytosolic second messengers of noradrenaline to active UCP1.	Norepinephrine	110-123	uncoupling protein 1	Homo sapiens	134-138
12561530-5	2001	The coupling of cell respiration with ADP phosphorylation is only partial in brown adipose tissue (BAT) mitochondria, where UCP causes a reentry of protons into the matrix and abolishes the electrochemical proton gradient.	Adenosine Diphosphate	38-41	uncoupling protein 1	Homo sapiens	124-127
11468281-5	2001	They are analogues of fatty acids, and they are transported by UCP1, UCP2, and UCP3.	Fatty Acids	22-33	uncoupling protein 1	Homo sapiens	63-67
11468281-6	2001	We show that undecanesulfonate and laurate are mutually competitive inhibitors, supporting the hypothesis that fatty acid anion is transported by UCP1.	undecanesulfonate	13-30	uncoupling protein 1	Homo sapiens	146-150
11468281-6	2001	We show that undecanesulfonate and laurate are mutually competitive inhibitors, supporting the hypothesis that fatty acid anion is transported by UCP1.	Laurates	35-42	uncoupling protein 1	Homo sapiens	146-150
11468281-6	2001	We show that undecanesulfonate and laurate are mutually competitive inhibitors, supporting the hypothesis that fatty acid anion is transported by UCP1.	fatty acid anion	111-127	uncoupling protein 1	Homo sapiens	146-150
11369767-0	2001	beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase.	Cyclic AMP	60-64	uncoupling protein 1	Homo sapiens	82-102
11369767-0	2001	beta-Adrenergic activation of p38 MAP kinase in adipocytes: cAMP induction of the uncoupling protein 1 (UCP1) gene requires p38 MAP kinase.	Cyclic AMP	60-64	uncoupling protein 1	Homo sapiens	104-108
11369767-2	2001	Here we show that the beta(3)-adrenergic receptor (beta(3)AR) stimulates p38 mitogen-activated protein kinase (p38 MAPK) via PKA in adipocytes and that cAMP-dependent transcription of the mitochondrial uncoupling protein 1 (UCP1) promoter by beta(3)AR requires p38 MAPK.	Cyclic AMP	152-156	uncoupling protein 1	Homo sapiens	224-228
11369767-7	2001	Treatment of primary brown adipocytes with CL or forskolin induced the expression of UCP1 mRNA levels (6.8- +/- 0.8-fold), and this response was eliminated by PKA inhibitors and SB202190.	Colforsin	49-58	uncoupling protein 1	Homo sapiens	85-89
11369767-8	2001	A similar stimulation of a 3.7-kilobase UCP1 promoter by CL and forskolin was also completely inhibited by PKA inhibitors and SB202190, indicating that these effects on UCP1 expression are transcriptional.	Colforsin	64-73	uncoupling protein 1	Homo sapiens	40-44
11369767-8	2001	A similar stimulation of a 3.7-kilobase UCP1 promoter by CL and forskolin was also completely inhibited by PKA inhibitors and SB202190, indicating that these effects on UCP1 expression are transcriptional.	Colforsin	64-73	uncoupling protein 1	Homo sapiens	169-173
11369767-8	2001	A similar stimulation of a 3.7-kilobase UCP1 promoter by CL and forskolin was also completely inhibited by PKA inhibitors and SB202190, indicating that these effects on UCP1 expression are transcriptional.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	126-134	uncoupling protein 1	Homo sapiens	40-44
11369767-8	2001	A similar stimulation of a 3.7-kilobase UCP1 promoter by CL and forskolin was also completely inhibited by PKA inhibitors and SB202190, indicating that these effects on UCP1 expression are transcriptional.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	126-134	uncoupling protein 1	Homo sapiens	169-173
11369767-11	2001	Together, these studies illustrate that p38 MAPK is an important downstream target of the beta-adrenergic/cAMP/PKA signaling pathway in adipocytes, and one of the functional consequences of this cascade is stimulation of UCP1 gene expression in brown adipocytes.	Cyclic AMP	106-110	uncoupling protein 1	Homo sapiens	221-225
11278377-1	2001	Fatty acids have been postulated to regulate uncoupling protein (UCP) gene expression in skeletal muscle in vivo.	Fatty Acids	0-11	uncoupling protein 1	Homo sapiens	45-63
11381268-3	2001	Like its close relatives UCP1 and UCP3, UCP2 uncouples proton entry in the mitochondrial matrix from ATP synthesis and is therefore a candidate gene for obesity.	Adenosine Triphosphate	101-104	uncoupling protein 1	Homo sapiens	25-29
11336791-10	2001	As H89 also abolished forskolin-induced UCP1 gene expression, and potentiated selective beta(3)-AR-induced cAMP production, H89 must be active downstream of cAMP.	Colforsin	22-31	uncoupling protein 1	Homo sapiens	40-44
11278377-1	2001	Fatty acids have been postulated to regulate uncoupling protein (UCP) gene expression in skeletal muscle in vivo.	Fatty Acids	0-11	uncoupling protein 1	Homo sapiens	65-68
11721329-3	2001	Mediated by beta-3 noradrenergic receptor and in the presence of triiodothyronine (T3), NE promotes the synthesis of the uncoupling protein 1 (UCP1).	Triiodothyronine	65-81	uncoupling protein 1	Homo sapiens	121-141
11725872-1	2001	Evidence has been provided that the plant uncoupling proteins (pUCP) play basic physiological roles similar to the other uncoupling protein subfamily members (mammalian UCP1,2,3,4 and BMCP) and are effective in the situations of slight uncoupling that leads to: (1) accelerated respiration and metabolic rates that are beneficial to plant growth and development; (2) decreased formation of reactive oxygen species in mitochondria; and, (3) mild thermogenesis, inevitably accompanying the previous two phenomena.	Reactive Oxygen Species	390-413	uncoupling protein 1	Homo sapiens	169-173
11171965-1	2001	Based on the discovery of coenzyme Q (CoQ) as an obligatory cofactor for H(+) transport by uncoupling protein 1 (UCP1) [Echtay, K. S., Winkler, E. &amp; Klingenberg, M. (2000) Nature (London) 408, 609-613] we show here that UCP2 and UCP3 are also highly active H(+) transporters and require CoQ and fatty acid for H(+) transport, which is inhibited by low concentrations of nucleotides.	Ubiquinone	38-41	uncoupling protein 1	Homo sapiens	91-111
11171965-1	2001	Based on the discovery of coenzyme Q (CoQ) as an obligatory cofactor for H(+) transport by uncoupling protein 1 (UCP1) [Echtay, K. S., Winkler, E. &amp; Klingenberg, M. (2000) Nature (London) 408, 609-613] we show here that UCP2 and UCP3 are also highly active H(+) transporters and require CoQ and fatty acid for H(+) transport, which is inhibited by low concentrations of nucleotides.	Ubiquinone	38-41	uncoupling protein 1	Homo sapiens	113-117
11171965-1	2001	Based on the discovery of coenzyme Q (CoQ) as an obligatory cofactor for H(+) transport by uncoupling protein 1 (UCP1) [Echtay, K. S., Winkler, E. &amp; Klingenberg, M. (2000) Nature (London) 408, 609-613] we show here that UCP2 and UCP3 are also highly active H(+) transporters and require CoQ and fatty acid for H(+) transport, which is inhibited by low concentrations of nucleotides.	Adenosine Monophosphate	148-151	uncoupling protein 1	Homo sapiens	91-111
11171965-1	2001	Based on the discovery of coenzyme Q (CoQ) as an obligatory cofactor for H(+) transport by uncoupling protein 1 (UCP1) [Echtay, K. S., Winkler, E. &amp; Klingenberg, M. (2000) Nature (London) 408, 609-613] we show here that UCP2 and UCP3 are also highly active H(+) transporters and require CoQ and fatty acid for H(+) transport, which is inhibited by low concentrations of nucleotides.	Adenosine Monophosphate	148-151	uncoupling protein 1	Homo sapiens	113-117
11171965-1	2001	Based on the discovery of coenzyme Q (CoQ) as an obligatory cofactor for H(+) transport by uncoupling protein 1 (UCP1) [Echtay, K. S., Winkler, E. &amp; Klingenberg, M. (2000) Nature (London) 408, 609-613] we show here that UCP2 and UCP3 are also highly active H(+) transporters and require CoQ and fatty acid for H(+) transport, which is inhibited by low concentrations of nucleotides.	Ubiquinone	291-294	uncoupling protein 1	Homo sapiens	91-111
11171965-1	2001	Based on the discovery of coenzyme Q (CoQ) as an obligatory cofactor for H(+) transport by uncoupling protein 1 (UCP1) [Echtay, K. S., Winkler, E. &amp; Klingenberg, M. (2000) Nature (London) 408, 609-613] we show here that UCP2 and UCP3 are also highly active H(+) transporters and require CoQ and fatty acid for H(+) transport, which is inhibited by low concentrations of nucleotides.	Ubiquinone	291-294	uncoupling protein 1	Homo sapiens	113-117
11171965-1	2001	Based on the discovery of coenzyme Q (CoQ) as an obligatory cofactor for H(+) transport by uncoupling protein 1 (UCP1) [Echtay, K. S., Winkler, E. &amp; Klingenberg, M. (2000) Nature (London) 408, 609-613] we show here that UCP2 and UCP3 are also highly active H(+) transporters and require CoQ and fatty acid for H(+) transport, which is inhibited by low concentrations of nucleotides.	Fatty Acids	299-309	uncoupling protein 1	Homo sapiens	91-111
11171965-1	2001	Based on the discovery of coenzyme Q (CoQ) as an obligatory cofactor for H(+) transport by uncoupling protein 1 (UCP1) [Echtay, K. S., Winkler, E. &amp; Klingenberg, M. (2000) Nature (London) 408, 609-613] we show here that UCP2 and UCP3 are also highly active H(+) transporters and require CoQ and fatty acid for H(+) transport, which is inhibited by low concentrations of nucleotides.	Fatty Acids	299-309	uncoupling protein 1	Homo sapiens	113-117
11171965-2	2001	CoQ is proposed to facilitate injection of H(+) from fatty acid into UCP.	Ubiquinone	0-3	uncoupling protein 1	Homo sapiens	69-72
11171965-2	2001	CoQ is proposed to facilitate injection of H(+) from fatty acid into UCP.	Fatty Acids	53-63	uncoupling protein 1	Homo sapiens	69-72
11171965-9	2001	In UCP2 as in UCP1, ATP is a stronger inhibitor than ADP, but in UCP3 ADP inhibits more strongly than ATP.	Adenosine Triphosphate	20-23	uncoupling protein 1	Homo sapiens	14-18
11239486-2	2001	The heat generation capacity is based on the uncoupling of respiration from ATP synthesis mediated by the uncoupling protein UCP1.	Adenosine Triphosphate	76-79	uncoupling protein 1	Homo sapiens	125-129
11239486-8	2001	Second, there exists a precise correlation between fatty acid sensitivity and the levels of UCP1.	Fatty Acids	51-61	uncoupling protein 1	Homo sapiens	92-96
11239486-10	2001	The regulation of UCP1 and UCP2 by retinoids and the lack of effects of fatty acids on UCP2 or UCP3 are starting to set differences among the new uncoupling proteins.	Retinoids	35-44	uncoupling protein 1	Homo sapiens	18-22
11257461-0	2001	Changes in UCP mRNA expression levels in brown adipose tissue and skeletal muscle after feeding a high-energy diet and relationships with leptin, glucose and PPARgamma.	Glucose	146-153	uncoupling protein 1	Homo sapiens	11-14
11341297-0	2001	GG-genotype in the promotor region of uncoupling-protein-1 gene is associated with lower level of dehydroepiandrosterone in type 2 diabetes.	Dehydroepiandrosterone	98-120	uncoupling protein 1	Homo sapiens	38-58
11721329-3	2001	Mediated by beta-3 noradrenergic receptor and in the presence of triiodothyronine (T3), NE promotes the synthesis of the uncoupling protein 1 (UCP1).	Triiodothyronine	65-81	uncoupling protein 1	Homo sapiens	143-147
11721329-3	2001	Mediated by beta-3 noradrenergic receptor and in the presence of triiodothyronine (T3), NE promotes the synthesis of the uncoupling protein 1 (UCP1).	Triiodothyronine	83-85	uncoupling protein 1	Homo sapiens	121-141
11721329-3	2001	Mediated by beta-3 noradrenergic receptor and in the presence of triiodothyronine (T3), NE promotes the synthesis of the uncoupling protein 1 (UCP1).	Triiodothyronine	83-85	uncoupling protein 1	Homo sapiens	143-147
10921912-2	2000	Uncoupling protein 1 (UCP1) is uniquely expressed in brown adipocytes and generates heat production by uncoupling respiration from ATP synthesis.	Adenosine Triphosphate	131-134	uncoupling protein 1	Homo sapiens	0-26
10921912-3	2000	The activatory effects of norepinephrine and retinoic acid (RA) on rodent ucp1 gene transcription have been well characterized.	Norepinephrine	26-40	uncoupling protein 1	Homo sapiens	74-78
10921912-3	2000	The activatory effects of norepinephrine and retinoic acid (RA) on rodent ucp1 gene transcription have been well characterized.	Tretinoin	45-58	uncoupling protein 1	Homo sapiens	74-78
10921912-3	2000	The activatory effects of norepinephrine and retinoic acid (RA) on rodent ucp1 gene transcription have been well characterized.	Tretinoin	60-62	uncoupling protein 1	Homo sapiens	74-78
10957931-9	2000	Until further information is available, treatment with imipramine or trazodone has been shown to offer effective relief of chest pain for subgroups of patients with UCP.	Imipramine	55-65	uncoupling protein 1	Homo sapiens	165-168
11004454-1	2000	According to the proton buffering model, introduced by Klingenberg, UCP1 conducts protons through a hydrophilic pathway lined with fatty acid head groups that buffer the protons as they move across the membrane.	Fatty Acids	131-141	uncoupling protein 1	Homo sapiens	68-72
11004454-5	2000	Because the carboxylate head group is translocated by UCP, and because the protonated FA rapidly diffuses across the membrane, this mechanism permits FA to behave as regulated cycling protonophores.	carboxylate	12-23	uncoupling protein 1	Homo sapiens	54-57
11004454-6	2000	Favoring the latter mechanism is the fact that the head group of long-chain alkylsulfonates, strong acid analogues of FA, is also translocated by UCP.	Alkanesulfonates	76-91	uncoupling protein 1	Homo sapiens	146-149
10957931-9	2000	Until further information is available, treatment with imipramine or trazodone has been shown to offer effective relief of chest pain for subgroups of patients with UCP.	Trazodone	69-78	uncoupling protein 1	Homo sapiens	165-168
10605819-4	1999	The coupling between respiration and ADP phosphorylation is only partial in brown adipose tissue (BAT) mitochondria, where the uncoupling protein UCP1 causes a reentry of protons into the matrix and abolishes the electrochemical proton gradient.	Adenosine Diphosphate	37-40	uncoupling protein 1	Homo sapiens	146-150
10702757-6	2000	GG carriers of the A--&gt;G variant of the UCP1 gene showed BMI-associated increases of cholesterol levels which were more marked than both AA (P=0.027) and AG (P=0.039) carriers.	Cholesterol	88-99	uncoupling protein 1	Homo sapiens	43-47
10997617-5	2000	Activity and expression of the three UCP"s are stimulated by several neuromediators and hormones such as noradrenaline, tri-iodothyronine and leptin.	Norepinephrine	105-118	uncoupling protein 1	Homo sapiens	37-40
10997617-5	2000	Activity and expression of the three UCP"s are stimulated by several neuromediators and hormones such as noradrenaline, tri-iodothyronine and leptin.	Triiodothyronine	120-137	uncoupling protein 1	Homo sapiens	37-40
10785338-0	2000	Effect of postnatal age and beta(3)-adrenergic agonist (Zeneca D7114) administration on uncoupling protein-1 abundance in the lamb	zeneca d7114	56-68	uncoupling protein 1	Homo sapiens	88-108
10608838-1	1999	The mechanism behind the distinctive non-Michaelis-Menten, bell-shaped kinetics of cAMP accumulation in brown adipocytes (which underlies the similar kinetics of UCP1 and beta(1)-adrenoreceptor gene expression) was investigated.	Cyclic AMP	83-87	uncoupling protein 1	Homo sapiens	162-166
10465291-6	1999	The increases in cAMP levels could adequately explain the increased cell proliferation in NE-stimulated preadipocytes and the NE-induced UCP1 gene expression in mature brown adipocytes.	Cyclic AMP	17-21	uncoupling protein 1	Homo sapiens	137-141
10653474-1	1999	The phenomena of fatty acid interaction with mitochondrial integral membrane proteins, namely uncoupling proteins (UCPs), are reviewed to emphasize the fatty acid cycling mechanism that has been suggested to explain the UCP function.	Fatty Acids	17-27	uncoupling protein 1	Homo sapiens	115-118
10653474-1	1999	The phenomena of fatty acid interaction with mitochondrial integral membrane proteins, namely uncoupling proteins (UCPs), are reviewed to emphasize the fatty acid cycling mechanism that has been suggested to explain the UCP function.	Fatty Acids	152-162	uncoupling protein 1	Homo sapiens	115-118
10653474-3	1999	Fatty acid interaction with the "classic" uncoupling protein (UCP1) from mitochondria of thermogenic brown adipose tissue (BAT) is well known.	Fatty Acids	0-10	uncoupling protein 1	Homo sapiens	62-66
10653474-4	1999	UCP1 is considered to mediate purine nucleotide-sensitive uniport of monovalent unipolar anions, including anionic fatty acids.	Purine Nucleotides	30-47	uncoupling protein 1	Homo sapiens	0-4
10653474-4	1999	UCP1 is considered to mediate purine nucleotide-sensitive uniport of monovalent unipolar anions, including anionic fatty acids.	anionic fatty acids	107-126	uncoupling protein 1	Homo sapiens	0-4
19649977-3	1999	UCP1 functions as a proton translocator regulated by fatty acids.	Fatty Acids	53-64	uncoupling protein 1	Homo sapiens	0-4
10566652-10	1999	Finally, the strong association between thyroid hormone and skeletal muscle UCP and the correlation between plasma free fatty acids and UCP expression in skeletal muscle indicate that these hormones/metabolites might influence UCP expression in humans as previously demonstrated in rodents.	Fatty Acids, Nonesterified	115-131	uncoupling protein 1	Homo sapiens	136-139
10566652-10	1999	Finally, the strong association between thyroid hormone and skeletal muscle UCP and the correlation between plasma free fatty acids and UCP expression in skeletal muscle indicate that these hormones/metabolites might influence UCP expression in humans as previously demonstrated in rodents.	Fatty Acids, Nonesterified	115-131	uncoupling protein 1	Homo sapiens	136-139
10409268-2	1999	In this study, primary brown adipocyte cultures were used to determine the role of beta-AR subtypes in mediating lipolysis and uncoupling protein-1 (UCP1) gene expression, elicited by the physiological neurohormone norepinephrine (NE).	Norepinephrine	215-229	uncoupling protein 1	Homo sapiens	127-153
10409268-3	1999	NE increased both lipolysis and UCP1 mRNA levels in brown adipocyte cultures; the beta(1)-receptor-selective antagonist CGP-20712A strongly antagonized the increase in UCP1 gene expression but had little effect on lipolysis.	CGP 20712A	120-130	uncoupling protein 1	Homo sapiens	168-172
10409268-4	1999	The beta(3)-receptor-selective agonist CL-316243 (CL) also increased lipolysis and UCP1 mRNA levels, yet CL was more potent in stimulating lipolysis than UCP1 gene expression.	disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate	39-48	uncoupling protein 1	Homo sapiens	83-87
10094571-6	1999	Retinoic acid (RA) has a specific effect on brown adipose tissue, because it activates transcription of the gene for uncoupling protein-1, responsible for brown fat thermogenesis.	Tretinoin	0-13	uncoupling protein 1	Homo sapiens	117-137
10364186-2	1999	We generated HeLa cells containing plasmids allowing doxycycline-inducible expression of uncoupling protein (UCP)-1.	Doxycycline	53-64	uncoupling protein 1	Homo sapiens	89-115
10364186-4	1999	In the presence of doxycycline, UCP-1 was expressed and oxygen consumption doubled.	Doxycycline	19-30	uncoupling protein 1	Homo sapiens	32-37
10412376-2	1999	One hour after administration of the beta 3-adrenoceptor agonist Trecadrine, a statistically significant increase in UCP1 messenger RNA (mRNA) expression in BAT was observed, whereas UCP2 and UCP3 in both BAT and gastrocnemius muscle were unaffected.	trecadrine	65-75	uncoupling protein 1	Homo sapiens	117-121
10071761-3	1999	Recent studies have shown that the sympathetic nervous system, via norepinephrine (beta-adrenoceptors) and cAMP, as well as thyroid hormones and PPAR gamma ligands seem to be major regulators of UCP expression.	Norepinephrine	67-81	uncoupling protein 1	Homo sapiens	195-198
10071761-3	1999	Recent studies have shown that the sympathetic nervous system, via norepinephrine (beta-adrenoceptors) and cAMP, as well as thyroid hormones and PPAR gamma ligands seem to be major regulators of UCP expression.	Cyclic AMP	107-111	uncoupling protein 1	Homo sapiens	195-198
9839442-7	1998	UCP-1 mediates a purine-nucleotide-sensitive uniport of monovalent unipolar anions, including fatty acids, that lead to fatty acid cycling and uncoupling.	purine	17-23	uncoupling protein 1	Homo sapiens	0-5
10645145-3	1999	The consequence of catecholamine activation of beta 3-AR is increased mobilization of fatty acids from triglyceride stores (lipolysis) in brown and white adipose tissue as well as increased fatty acid beta-oxidation and heat-production via UCP-1 (thermogenesis) in brown adipose tissue.	Catecholamines	19-32	uncoupling protein 1	Homo sapiens	240-245
9839442-7	1998	UCP-1 mediates a purine-nucleotide-sensitive uniport of monovalent unipolar anions, including fatty acids, that lead to fatty acid cycling and uncoupling.	Fatty Acids	94-105	uncoupling protein 1	Homo sapiens	0-5
9839442-7	1998	UCP-1 mediates a purine-nucleotide-sensitive uniport of monovalent unipolar anions, including fatty acids, that lead to fatty acid cycling and uncoupling.	Fatty Acids	94-104	uncoupling protein 1	Homo sapiens	0-5
9688604-2	1998	We studied pyruvate, alpha-ketoisovalerate, alpha-ketoisocaproate, and phenylpyruvate uniport via the uncoupling protein (UCP1) as a GDP-sensitive swelling in K+ salts induced by valinomycin or by monensin and carbonyl cyanide-p-(trifluoromethoxy)phenylhydrazone in Na+ salts.	Pyruvic Acid	11-19	uncoupling protein 1	Homo sapiens	122-126
9826220-0	1998	Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia.	Fatty Acids, Nonesterified	24-39	uncoupling protein 1	Homo sapiens	178-198
9826220-0	1998	Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia.	Glucose	51-58	uncoupling protein 1	Homo sapiens	178-198
9688604-2	1998	We studied pyruvate, alpha-ketoisovalerate, alpha-ketoisocaproate, and phenylpyruvate uniport via the uncoupling protein (UCP1) as a GDP-sensitive swelling in K+ salts induced by valinomycin or by monensin and carbonyl cyanide-p-(trifluoromethoxy)phenylhydrazone in Na+ salts.	alpha-ketoisovalerate	21-42	uncoupling protein 1	Homo sapiens	122-126
9688604-2	1998	We studied pyruvate, alpha-ketoisovalerate, alpha-ketoisocaproate, and phenylpyruvate uniport via the uncoupling protein (UCP1) as a GDP-sensitive swelling in K+ salts induced by valinomycin or by monensin and carbonyl cyanide-p-(trifluoromethoxy)phenylhydrazone in Na+ salts.	phenylpyruvic acid	71-85	uncoupling protein 1	Homo sapiens	122-126
9688604-2	1998	We studied pyruvate, alpha-ketoisovalerate, alpha-ketoisocaproate, and phenylpyruvate uniport via the uncoupling protein (UCP1) as a GDP-sensitive swelling in K+ salts induced by valinomycin or by monensin and carbonyl cyanide-p-(trifluoromethoxy)phenylhydrazone in Na+ salts.	Guanosine Diphosphate	133-136	uncoupling protein 1	Homo sapiens	122-126
9688604-2	1998	We studied pyruvate, alpha-ketoisovalerate, alpha-ketoisocaproate, and phenylpyruvate uniport via the uncoupling protein (UCP1) as a GDP-sensitive swelling in K+ salts induced by valinomycin or by monensin and carbonyl cyanide-p-(trifluoromethoxy)phenylhydrazone in Na+ salts.	k+ salts	159-167	uncoupling protein 1	Homo sapiens	122-126
9688604-2	1998	We studied pyruvate, alpha-ketoisovalerate, alpha-ketoisocaproate, and phenylpyruvate uniport via the uncoupling protein (UCP1) as a GDP-sensitive swelling in K+ salts induced by valinomycin or by monensin and carbonyl cyanide-p-(trifluoromethoxy)phenylhydrazone in Na+ salts.	Valinomycin	179-190	uncoupling protein 1	Homo sapiens	122-126
9688604-2	1998	We studied pyruvate, alpha-ketoisovalerate, alpha-ketoisocaproate, and phenylpyruvate uniport via the uncoupling protein (UCP1) as a GDP-sensitive swelling in K+ salts induced by valinomycin or by monensin and carbonyl cyanide-p-(trifluoromethoxy)phenylhydrazone in Na+ salts.	Monensin	197-205	uncoupling protein 1	Homo sapiens	122-126
9688604-2	1998	We studied pyruvate, alpha-ketoisovalerate, alpha-ketoisocaproate, and phenylpyruvate uniport via the uncoupling protein (UCP1) as a GDP-sensitive swelling in K+ salts induced by valinomycin or by monensin and carbonyl cyanide-p-(trifluoromethoxy)phenylhydrazone in Na+ salts.	carbonyl cyanide-p-(trifluoromethoxy)phenylhydrazone	210-262	uncoupling protein 1	Homo sapiens	122-126
9688604-2	1998	We studied pyruvate, alpha-ketoisovalerate, alpha-ketoisocaproate, and phenylpyruvate uniport via the uncoupling protein (UCP1) as a GDP-sensitive swelling in K+ salts induced by valinomycin or by monensin and carbonyl cyanide-p-(trifluoromethoxy)phenylhydrazone in Na+ salts.	na+ salts	266-275	uncoupling protein 1	Homo sapiens	122-126
9688604-7	1998	Consequently, we suggest that UCP1 might participate in futile cycling of unipolar ketocarboxylates under certain physiological conditions while expelling these anions from the matrix.	ketocarboxylates	83-99	uncoupling protein 1	Homo sapiens	30-34
9618150-4	1998	Transient transfection of dominant-negative form of phosphatidylinositol (PI) 3-kinase completely blocked the transactivation of the fusion gene UCP1-CAT induced by either IGF-I or insulin, although inhibition of p70S6kinase with rapamycin does not preclude transactivation of the UCP1 promoter by insulin.	Phosphatidylinositols	52-72	uncoupling protein 1	Homo sapiens	145-149
9618150-4	1998	Transient transfection of dominant-negative form of phosphatidylinositol (PI) 3-kinase completely blocked the transactivation of the fusion gene UCP1-CAT induced by either IGF-I or insulin, although inhibition of p70S6kinase with rapamycin does not preclude transactivation of the UCP1 promoter by insulin.	Phosphatidylinositols	52-72	uncoupling protein 1	Homo sapiens	281-285
9618150-2	1998	At physiological doses, either insulin-like growth factor I (IGF-I) or insulin turned out to be as potent as dibutyryl cAMP (dbcAMP) in increasing UCP1 gene transcription rate (1 h) and also UCP1 mRNA accumulation (3 h), their maximal effect (15-fold increase) reached upon treatment for 24 h. Upon treatment with either IGF-I or insulin for 48 h, a 7-fold increase in the UCP1 protein content relative to levels in the control cells was found, this induction being abolished in the presence of cycloheximide.	dibutyryl	109-118	uncoupling protein 1	Homo sapiens	147-151
9618150-4	1998	Transient transfection of dominant-negative form of phosphatidylinositol (PI) 3-kinase completely blocked the transactivation of the fusion gene UCP1-CAT induced by either IGF-I or insulin, although inhibition of p70S6kinase with rapamycin does not preclude transactivation of the UCP1 promoter by insulin.	Sirolimus	230-239	uncoupling protein 1	Homo sapiens	145-149
9618150-2	1998	At physiological doses, either insulin-like growth factor I (IGF-I) or insulin turned out to be as potent as dibutyryl cAMP (dbcAMP) in increasing UCP1 gene transcription rate (1 h) and also UCP1 mRNA accumulation (3 h), their maximal effect (15-fold increase) reached upon treatment for 24 h. Upon treatment with either IGF-I or insulin for 48 h, a 7-fold increase in the UCP1 protein content relative to levels in the control cells was found, this induction being abolished in the presence of cycloheximide.	Cyclic AMP	119-123	uncoupling protein 1	Homo sapiens	147-151
9618150-2	1998	At physiological doses, either insulin-like growth factor I (IGF-I) or insulin turned out to be as potent as dibutyryl cAMP (dbcAMP) in increasing UCP1 gene transcription rate (1 h) and also UCP1 mRNA accumulation (3 h), their maximal effect (15-fold increase) reached upon treatment for 24 h. Upon treatment with either IGF-I or insulin for 48 h, a 7-fold increase in the UCP1 protein content relative to levels in the control cells was found, this induction being abolished in the presence of cycloheximide.	Cyclic AMP	119-123	uncoupling protein 1	Homo sapiens	191-195
9618150-2	1998	At physiological doses, either insulin-like growth factor I (IGF-I) or insulin turned out to be as potent as dibutyryl cAMP (dbcAMP) in increasing UCP1 gene transcription rate (1 h) and also UCP1 mRNA accumulation (3 h), their maximal effect (15-fold increase) reached upon treatment for 24 h. Upon treatment with either IGF-I or insulin for 48 h, a 7-fold increase in the UCP1 protein content relative to levels in the control cells was found, this induction being abolished in the presence of cycloheximide.	Cyclic AMP	119-123	uncoupling protein 1	Homo sapiens	191-195
9618150-2	1998	At physiological doses, either insulin-like growth factor I (IGF-I) or insulin turned out to be as potent as dibutyryl cAMP (dbcAMP) in increasing UCP1 gene transcription rate (1 h) and also UCP1 mRNA accumulation (3 h), their maximal effect (15-fold increase) reached upon treatment for 24 h. Upon treatment with either IGF-I or insulin for 48 h, a 7-fold increase in the UCP1 protein content relative to levels in the control cells was found, this induction being abolished in the presence of cycloheximide.	Bucladesine	125-131	uncoupling protein 1	Homo sapiens	147-151
9618150-2	1998	At physiological doses, either insulin-like growth factor I (IGF-I) or insulin turned out to be as potent as dibutyryl cAMP (dbcAMP) in increasing UCP1 gene transcription rate (1 h) and also UCP1 mRNA accumulation (3 h), their maximal effect (15-fold increase) reached upon treatment for 24 h. Upon treatment with either IGF-I or insulin for 48 h, a 7-fold increase in the UCP1 protein content relative to levels in the control cells was found, this induction being abolished in the presence of cycloheximide.	Bucladesine	125-131	uncoupling protein 1	Homo sapiens	191-195
9618150-2	1998	At physiological doses, either insulin-like growth factor I (IGF-I) or insulin turned out to be as potent as dibutyryl cAMP (dbcAMP) in increasing UCP1 gene transcription rate (1 h) and also UCP1 mRNA accumulation (3 h), their maximal effect (15-fold increase) reached upon treatment for 24 h. Upon treatment with either IGF-I or insulin for 48 h, a 7-fold increase in the UCP1 protein content relative to levels in the control cells was found, this induction being abolished in the presence of cycloheximide.	Bucladesine	125-131	uncoupling protein 1	Homo sapiens	191-195
9618150-5	1998	Furthermore, transient transfection of dominant-negative form of p21-ras or treatment of cells with a mitogen-activated protein kinase kinase (MEK-1) inhibitor (PD098059) completely abolished insulin-induced UCP1-CAT transactivation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	161-169	uncoupling protein 1	Homo sapiens	208-212
9693744-5	1998	Fatty acid cycling was documented for UCP-1, PUMP and ADP/ATP carrier, and is predicted also for UCP-2 and UCP-3.	Fatty Acids	0-10	uncoupling protein 1	Homo sapiens	38-43
9693744-6	1998	UCP-1 mediates a purine nucleotide-sensitive uniport of monovalent unipolar anions, including anionic fatty acids.	Purine Nucleotides	17-34	uncoupling protein 1	Homo sapiens	0-5
9693744-6	1998	UCP-1 mediates a purine nucleotide-sensitive uniport of monovalent unipolar anions, including anionic fatty acids.	anionic fatty acids	94-113	uncoupling protein 1	Homo sapiens	0-5
9548581-8	1998	The only putative FA transport protein to be purified and reconstituted into phospholipid bilayers, the mitochondrial uncoupling protein (UCP1), was shown to transport the FA anion in response to FA flip-flop.	Phospholipids	77-89	uncoupling protein 1	Homo sapiens	138-142
9785103-1	1998	Mitochondrial uncoupling protein (UcP) contains two tryptophans buried in transmembrane alpha-helices: Trp-173 at the matrix end of fourth alpha-helix and Trp-280 on the sixth alpha-helix.	Tryptophan	52-63	uncoupling protein 1	Homo sapiens	34-37
9785103-1	1998	Mitochondrial uncoupling protein (UcP) contains two tryptophans buried in transmembrane alpha-helices: Trp-173 at the matrix end of fourth alpha-helix and Trp-280 on the sixth alpha-helix.	Tryptophan	103-106	uncoupling protein 1	Homo sapiens	34-37
9785103-1	1998	Mitochondrial uncoupling protein (UcP) contains two tryptophans buried in transmembrane alpha-helices: Trp-173 at the matrix end of fourth alpha-helix and Trp-280 on the sixth alpha-helix.	Tryptophan	155-158	uncoupling protein 1	Homo sapiens	34-37
9785103-2	1998	However, the steady-state emission of isolated UcP exhibited properties unusual for alpha-helices: maximum close to that of free tryptophan emission and low quantum yield of 0.04.	Tryptophan	129-139	uncoupling protein 1	Homo sapiens	47-50
9785103-6	1998	Analysis of UcP emission decays, measured by time-correlated-single-photon-counting, yielded components 0.4-0.6 ns, 2.2-3 ns and 9-10 ns (or alternatively 0.1, 1.5, 4.3 and 12.2 ns; or 0.1-0.3, 1.2, 3.7 and 10.5 ns), very similar to those of free tryptophan in water, where the longest component belongs to anionic form.	Tryptophan	247-257	uncoupling protein 1	Homo sapiens	12-15
9785103-6	1998	Analysis of UcP emission decays, measured by time-correlated-single-photon-counting, yielded components 0.4-0.6 ns, 2.2-3 ns and 9-10 ns (or alternatively 0.1, 1.5, 4.3 and 12.2 ns; or 0.1-0.3, 1.2, 3.7 and 10.5 ns), very similar to those of free tryptophan in water, where the longest component belongs to anionic form.	Water	261-266	uncoupling protein 1	Homo sapiens	12-15
9785103-7	1998	Hence, such an "anionic" conformation must exist in UcP, perhaps as a consequence of charge-transfer complexes between Trp-173 &amp; Lys-174 and Trp-280 &amp; Arg-276.	Tryptophan	119-122	uncoupling protein 1	Homo sapiens	52-55
9785103-7	1998	Hence, such an "anionic" conformation must exist in UcP, perhaps as a consequence of charge-transfer complexes between Trp-173 &amp; Lys-174 and Trp-280 &amp; Arg-276.	Adenosine Monophosphate	128-131	uncoupling protein 1	Homo sapiens	52-55
9785103-7	1998	Hence, such an "anionic" conformation must exist in UcP, perhaps as a consequence of charge-transfer complexes between Trp-173 &amp; Lys-174 and Trp-280 &amp; Arg-276.	Lysine	133-136	uncoupling protein 1	Homo sapiens	52-55
9785103-7	1998	Hence, such an "anionic" conformation must exist in UcP, perhaps as a consequence of charge-transfer complexes between Trp-173 &amp; Lys-174 and Trp-280 &amp; Arg-276.	Tryptophan	145-148	uncoupling protein 1	Homo sapiens	52-55
9785103-7	1998	Hence, such an "anionic" conformation must exist in UcP, perhaps as a consequence of charge-transfer complexes between Trp-173 &amp; Lys-174 and Trp-280 &amp; Arg-276.	Adenosine Monophosphate	154-157	uncoupling protein 1	Homo sapiens	52-55
9785103-7	1998	Hence, such an "anionic" conformation must exist in UcP, perhaps as a consequence of charge-transfer complexes between Trp-173 &amp; Lys-174 and Trp-280 &amp; Arg-276.	Arginine	159-162	uncoupling protein 1	Homo sapiens	52-55
9555947-6	1998	The importance of sequence variations at the UCP-1 gene locus as a common source of UCP-1 mRNA abundance variability was supported by allele-specific expression studies utilizing a newly identified polymorphism in exon 2 of the UCP-1 gene that predicts a substitution of alanine by threonine.	Alanine	271-278	uncoupling protein 1	Homo sapiens	45-50
9555947-6	1998	The importance of sequence variations at the UCP-1 gene locus as a common source of UCP-1 mRNA abundance variability was supported by allele-specific expression studies utilizing a newly identified polymorphism in exon 2 of the UCP-1 gene that predicts a substitution of alanine by threonine.	Alanine	271-278	uncoupling protein 1	Homo sapiens	84-89
9555947-6	1998	The importance of sequence variations at the UCP-1 gene locus as a common source of UCP-1 mRNA abundance variability was supported by allele-specific expression studies utilizing a newly identified polymorphism in exon 2 of the UCP-1 gene that predicts a substitution of alanine by threonine.	Alanine	271-278	uncoupling protein 1	Homo sapiens	84-89
9555947-6	1998	The importance of sequence variations at the UCP-1 gene locus as a common source of UCP-1 mRNA abundance variability was supported by allele-specific expression studies utilizing a newly identified polymorphism in exon 2 of the UCP-1 gene that predicts a substitution of alanine by threonine.	Threonine	282-291	uncoupling protein 1	Homo sapiens	45-50
9555947-6	1998	The importance of sequence variations at the UCP-1 gene locus as a common source of UCP-1 mRNA abundance variability was supported by allele-specific expression studies utilizing a newly identified polymorphism in exon 2 of the UCP-1 gene that predicts a substitution of alanine by threonine.	Threonine	282-291	uncoupling protein 1	Homo sapiens	84-89
9555947-6	1998	The importance of sequence variations at the UCP-1 gene locus as a common source of UCP-1 mRNA abundance variability was supported by allele-specific expression studies utilizing a newly identified polymorphism in exon 2 of the UCP-1 gene that predicts a substitution of alanine by threonine.	Threonine	282-291	uncoupling protein 1	Homo sapiens	84-89
9421389-0	1998	Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes.	2,4-thiazolidinedione	0-17	uncoupling protein 1	Homo sapiens	55-75
9421389-9	1998	Thus, cells of the brown fat lineage were detectable in all human adipose depots studied, and cultured human pre-adipocytes, particularly from the perirenal depot, showed a marked increase in UCP-1 expression in response to thiazolidinediones.	Thiazolidinediones	224-242	uncoupling protein 1	Homo sapiens	192-197
9389729-2	1997	UCP1 induces heat production by uncoupling respiration from ATP synthesis.	Adenosine Triphosphate	60-63	uncoupling protein 1	Homo sapiens	0-4
9597749-3	1998	Norepinephrine, released from sympathetic terminals and acting via beta-adrenoceptors and cAMP, is the main positive regulator of both UCP synthesis and activity.	Norepinephrine	0-14	uncoupling protein 1	Homo sapiens	135-138
9597749-3	1998	Norepinephrine, released from sympathetic terminals and acting via beta-adrenoceptors and cAMP, is the main positive regulator of both UCP synthesis and activity.	Cyclic AMP	90-94	uncoupling protein 1	Homo sapiens	135-138
8988019-6	1996	The transport inhibitors (GTP, GDP, ATP, and ADP) also inhibit this channel in a reversible way, showing that the channel activity is associated with UCP.	Guanosine Triphosphate	26-29	uncoupling protein 1	Homo sapiens	150-153
9271366-4	1997	Preincubation of BAT mitochondrial fractions with GDP, an inhibitor of UCP1, induced a rise in mitochondrial membrane potential (assessed by rhodamine 123 uptake) and H2O2 production.	Guanosine Diphosphate	50-53	uncoupling protein 1	Homo sapiens	71-75
9187360-1	1997	Fatty acid (FA) uniport via mitochondrial uncoupling protein (UcP) was detected fluorometrically with PBFI, potassium-binding benzofuran phthalate and SPQ, 6-methoxy-N-(3-sulfopropyl)-quinolinium, indicating K+ and H+, respectively.	Fatty Acids	0-10	uncoupling protein 1	Homo sapiens	62-65
9187360-1	1997	Fatty acid (FA) uniport via mitochondrial uncoupling protein (UcP) was detected fluorometrically with PBFI, potassium-binding benzofuran phthalate and SPQ, 6-methoxy-N-(3-sulfopropyl)-quinolinium, indicating K+ and H+, respectively.	potassium-binding benzofuran isophthalate	102-106	uncoupling protein 1	Homo sapiens	62-65
9187360-1	1997	Fatty acid (FA) uniport via mitochondrial uncoupling protein (UcP) was detected fluorometrically with PBFI, potassium-binding benzofuran phthalate and SPQ, 6-methoxy-N-(3-sulfopropyl)-quinolinium, indicating K+ and H+, respectively.	Potassium	108-117	uncoupling protein 1	Homo sapiens	62-65
9187360-1	1997	Fatty acid (FA) uniport via mitochondrial uncoupling protein (UcP) was detected fluorometrically with PBFI, potassium-binding benzofuran phthalate and SPQ, 6-methoxy-N-(3-sulfopropyl)-quinolinium, indicating K+ and H+, respectively.	benzofuran phthalate	126-146	uncoupling protein 1	Homo sapiens	62-65
9187360-1	1997	Fatty acid (FA) uniport via mitochondrial uncoupling protein (UcP) was detected fluorometrically with PBFI, potassium-binding benzofuran phthalate and SPQ, 6-methoxy-N-(3-sulfopropyl)-quinolinium, indicating K+ and H+, respectively.	6-methoxy-N-(3-sulfopropyl)quinolinium	151-154	uncoupling protein 1	Homo sapiens	62-65
9187360-1	1997	Fatty acid (FA) uniport via mitochondrial uncoupling protein (UcP) was detected fluorometrically with PBFI, potassium-binding benzofuran phthalate and SPQ, 6-methoxy-N-(3-sulfopropyl)-quinolinium, indicating K+ and H+, respectively.	6-methoxy-N-(3-sulfopropyl)quinolinium	156-195	uncoupling protein 1	Homo sapiens	62-65
9271366-4	1997	Preincubation of BAT mitochondrial fractions with GDP, an inhibitor of UCP1, induced a rise in mitochondrial membrane potential (assessed by rhodamine 123 uptake) and H2O2 production.	Rhodamine 123	141-154	uncoupling protein 1	Homo sapiens	71-75
9271366-4	1997	Preincubation of BAT mitochondrial fractions with GDP, an inhibitor of UCP1, induced a rise in mitochondrial membrane potential (assessed by rhodamine 123 uptake) and H2O2 production.	Hydrogen Peroxide	167-171	uncoupling protein 1	Homo sapiens	71-75
8988019-6	1996	The transport inhibitors (GTP, GDP, ATP, and ADP) also inhibit this channel in a reversible way, showing that the channel activity is associated with UCP.	Guanosine Diphosphate	31-34	uncoupling protein 1	Homo sapiens	150-153
8988019-6	1996	The transport inhibitors (GTP, GDP, ATP, and ADP) also inhibit this channel in a reversible way, showing that the channel activity is associated with UCP.	Adenosine Triphosphate	36-39	uncoupling protein 1	Homo sapiens	150-153
8988019-6	1996	The transport inhibitors (GTP, GDP, ATP, and ADP) also inhibit this channel in a reversible way, showing that the channel activity is associated with UCP.	Adenosine Diphosphate	45-48	uncoupling protein 1	Homo sapiens	150-153
8988019-12	1996	The Cl- channel can be blocked by 4,4"-diisothiocyanatostilbene-2,2"-disulfonic acid (DIDS) from the matrix side of UCP.	4,4"-diisothiocyanatostilbene-2,2"-disulfonic acid	34-84	uncoupling protein 1	Homo sapiens	116-119
8988019-12	1996	The Cl- channel can be blocked by 4,4"-diisothiocyanatostilbene-2,2"-disulfonic acid (DIDS) from the matrix side of UCP.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	86-90	uncoupling protein 1	Homo sapiens	116-119
8672485-4	1996	Previously, by using fluorescent 2"-O-dansyl (DANS) derivatives of purine nucleotides, a two-stage binding mechanism was unraveled with a slow transition from a loose into a tight conformational state in the isolated UCP [Huang, S.-G., &amp; Klingenberg, M. (1995) Biochemistry 34, 349-360].	2"-o-dansyl	33-44	uncoupling protein 1	Homo sapiens	217-220
8672485-4	1996	Previously, by using fluorescent 2"-O-dansyl (DANS) derivatives of purine nucleotides, a two-stage binding mechanism was unraveled with a slow transition from a loose into a tight conformational state in the isolated UCP [Huang, S.-G., &amp; Klingenberg, M. (1995) Biochemistry 34, 349-360].	Purine Nucleotides	67-85	uncoupling protein 1	Homo sapiens	217-220
8672485-4	1996	Previously, by using fluorescent 2"-O-dansyl (DANS) derivatives of purine nucleotides, a two-stage binding mechanism was unraveled with a slow transition from a loose into a tight conformational state in the isolated UCP [Huang, S.-G., &amp; Klingenberg, M. (1995) Biochemistry 34, 349-360].	Adenosine Monophosphate	237-240	uncoupling protein 1	Homo sapiens	217-220
8672485-11	1996	This allows DANSAMP to replace prebound ATP from UCP and relieve the inhibition of H+ transport by reversing the distribution of UCP from the tight into the loose conformational state.	dansamp	12-19	uncoupling protein 1	Homo sapiens	49-52
8672485-11	1996	This allows DANSAMP to replace prebound ATP from UCP and relieve the inhibition of H+ transport by reversing the distribution of UCP from the tight into the loose conformational state.	dansamp	12-19	uncoupling protein 1	Homo sapiens	129-132
8672485-11	1996	This allows DANSAMP to replace prebound ATP from UCP and relieve the inhibition of H+ transport by reversing the distribution of UCP from the tight into the loose conformational state.	Adenosine Triphosphate	40-43	uncoupling protein 1	Homo sapiens	129-132
8672485-13	1996	Titration with DANS nucleotides of UCP incorporated into phospholipid vesicles revealed that over 70% of binding sites had an affinity comparable with that for the isolated UCP while the remaining sites displayed substantially lower affinity, due to nonhomogeneity of the reconstituted system.	Phospholipids	57-69	uncoupling protein 1	Homo sapiens	35-38
8626410-13	1996	In micromolar doses, AzDA activated H+ translocation and inhibited Cl- and hexanesulfonate uniport through UCP.	12-(4-azido-2-nitrophenylamino)dodecanoic acid	21-25	uncoupling protein 1	Homo sapiens	107-110
8626410-7	1996	In this model, UCP does not transport H+ at all but rather enables fatty acids to act as cycling protonophores.	Fatty Acids	67-78	uncoupling protein 1	Homo sapiens	15-18
8605977-3	1996	It was also possible to label with [3H]AzHA the isolated uncoupling protein (UcP) of BAT mitochondria with a low stoichiometry--lower than one AzHA per dimeric UcP.	Tritium	36-38	uncoupling protein 1	Homo sapiens	77-80
8605977-4	1996	These results together with the observed competition (i.e. prevention of photolabelling) of various UcP anionic substrates with [3H]AzHA and its dodecanoic acid analogue, suggest the existence of the specific fatty acid binding site on UcP identical with the anion channel or anion translocating site.	Tritium	129-131	uncoupling protein 1	Homo sapiens	100-103
8605977-4	1996	These results together with the observed competition (i.e. prevention of photolabelling) of various UcP anionic substrates with [3H]AzHA and its dodecanoic acid analogue, suggest the existence of the specific fatty acid binding site on UcP identical with the anion channel or anion translocating site.	Tritium	129-131	uncoupling protein 1	Homo sapiens	236-239
8605977-4	1996	These results together with the observed competition (i.e. prevention of photolabelling) of various UcP anionic substrates with [3H]AzHA and its dodecanoic acid analogue, suggest the existence of the specific fatty acid binding site on UcP identical with the anion channel or anion translocating site.	azha	132-136	uncoupling protein 1	Homo sapiens	100-103
8605977-4	1996	These results together with the observed competition (i.e. prevention of photolabelling) of various UcP anionic substrates with [3H]AzHA and its dodecanoic acid analogue, suggest the existence of the specific fatty acid binding site on UcP identical with the anion channel or anion translocating site.	azha	132-136	uncoupling protein 1	Homo sapiens	236-239
8605977-4	1996	These results together with the observed competition (i.e. prevention of photolabelling) of various UcP anionic substrates with [3H]AzHA and its dodecanoic acid analogue, suggest the existence of the specific fatty acid binding site on UcP identical with the anion channel or anion translocating site.	lauric acid	145-160	uncoupling protein 1	Homo sapiens	100-103
8605977-4	1996	These results together with the observed competition (i.e. prevention of photolabelling) of various UcP anionic substrates with [3H]AzHA and its dodecanoic acid analogue, suggest the existence of the specific fatty acid binding site on UcP identical with the anion channel or anion translocating site.	lauric acid	145-160	uncoupling protein 1	Homo sapiens	236-239
8605977-4	1996	These results together with the observed competition (i.e. prevention of photolabelling) of various UcP anionic substrates with [3H]AzHA and its dodecanoic acid analogue, suggest the existence of the specific fatty acid binding site on UcP identical with the anion channel or anion translocating site.	Fatty Acids	209-219	uncoupling protein 1	Homo sapiens	100-103
8605977-4	1996	These results together with the observed competition (i.e. prevention of photolabelling) of various UcP anionic substrates with [3H]AzHA and its dodecanoic acid analogue, suggest the existence of the specific fatty acid binding site on UcP identical with the anion channel or anion translocating site.	Fatty Acids	209-219	uncoupling protein 1	Homo sapiens	236-239
8626410-1	1996	The protonophoretic function of uncoupling protein (UCP) is activated by fatty acids.	Fatty Acids	73-84	uncoupling protein 1	Homo sapiens	52-55
8626410-4	1996	265, 19303-19311, 1990), the fatty acid binding site is identical with the anion channel of UCP.	Fatty Acids	29-39	uncoupling protein 1	Homo sapiens	92-95
8626410-13	1996	In micromolar doses, AzDA activated H+ translocation and inhibited Cl- and hexanesulfonate uniport through UCP.	hexanesulfonate	75-90	uncoupling protein 1	Homo sapiens	107-110
8626410-16	1996	Photolabeling of mitochondria with [3H]AzDA resulted in a prominent 32 kDa band of UCP, and few other proteins were labeled.	Tritium	36-38	uncoupling protein 1	Homo sapiens	83-86
8626410-16	1996	Photolabeling of mitochondria with [3H]AzDA resulted in a prominent 32 kDa band of UCP, and few other proteins were labeled.	12-(4-azido-2-nitrophenylamino)dodecanoic acid	39-43	uncoupling protein 1	Homo sapiens	83-86
8626410-18	1996	The finding that fatty acid-induced H+ transport disappears along with anion transport supports the fatty acid-protonophore mechanism of H+ transport by UCP.	Fatty Acids	17-27	uncoupling protein 1	Homo sapiens	153-156
8626410-18	1996	The finding that fatty acid-induced H+ transport disappears along with anion transport supports the fatty acid-protonophore mechanism of H+ transport by UCP.	Fatty Acids	100-110	uncoupling protein 1	Homo sapiens	153-156
1420170-1	1992	The nucleotide binding site of the uncoupling protein (UCP) from brown adipose tissue was mapped by photoaffinity labeling with 2-azidoadenosine 5"-triphosphate (2-azido-ATP) and by affinity labeling with 3"-O-(5-fluoro-2,4-dinitrophenyl)adenosine 5"-triphosphate (FDNP-ATP).	2-azidoadenosine 5'-triphosphate	128-160	uncoupling protein 1	Homo sapiens	55-58
8680475-6	1996	Cell differentiation is also adrenergically promoted; at least the expression of the gene for the tissue-specific uncoupling protein thermogenin is controlled via beta 3 receptors and cAMP.	Cyclic AMP	184-188	uncoupling protein 1	Homo sapiens	133-144
7819218-10	1995	This is interpreted in terms of tight/loose UCP-nucleotide complexes, 100% tight complex for DANSGTP (as well GTP or ATP) but 40% loose complex for DANSATP.	Guanosine Triphosphate	97-100	uncoupling protein 1	Homo sapiens	44-47
7819218-15	1995	This is in line with the very strong pH dependence of nucleoside triphosphate affinity above pH 7 with a delta pKD/delta pH = -2 as an important regulatory mechanism for the H+ transport activity of UCP.	[[(2R,3S,4R,5S)-3,4-dihydroxy-5-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate	54-77	uncoupling protein 1	Homo sapiens	199-202
8180235-1	1994	In order to study the function of the brown-fat specific uncoupling protein thermogenin (UCP), the effect of certain sulfonates on [3H]GDP binding to the GDP-binding site of brown adipose tissue mitochondria was studied.	Tritium	132-134	uncoupling protein 1	Homo sapiens	76-87
8180235-1	1994	In order to study the function of the brown-fat specific uncoupling protein thermogenin (UCP), the effect of certain sulfonates on [3H]GDP binding to the GDP-binding site of brown adipose tissue mitochondria was studied.	Guanosine Diphosphate	135-138	uncoupling protein 1	Homo sapiens	76-87
8180235-1	1994	In order to study the function of the brown-fat specific uncoupling protein thermogenin (UCP), the effect of certain sulfonates on [3H]GDP binding to the GDP-binding site of brown adipose tissue mitochondria was studied.	Guanosine Diphosphate	135-138	uncoupling protein 1	Homo sapiens	89-92
8180235-1	1994	In order to study the function of the brown-fat specific uncoupling protein thermogenin (UCP), the effect of certain sulfonates on [3H]GDP binding to the GDP-binding site of brown adipose tissue mitochondria was studied.	Guanosine Diphosphate	154-157	uncoupling protein 1	Homo sapiens	76-87
8180235-4	1994	Also in KCl-medium, the affinity of GDP was high (approximately 3 microM), but both in a benzenesulfonate medium and in a para-aminobenzenesulfonate (sulfanilate) medium, the apparent affinity was lower (approximately 12 microM); as benzenesulfonate is well transported by thermogenin but sulfanilate is not, the reduction in affinity was unrelated to transport.	Guanosine Diphosphate	36-39	uncoupling protein 1	Homo sapiens	273-284
8180235-9	1994	It was concluded that these types of substrate for thermogenin-mediated transport may directly interact with the GDP-binding site, but that this effect could only partly explain the dependence of GDP potency on substrate species.	Guanosine Diphosphate	113-116	uncoupling protein 1	Homo sapiens	51-62
8180235-9	1994	It was concluded that these types of substrate for thermogenin-mediated transport may directly interact with the GDP-binding site, but that this effect could only partly explain the dependence of GDP potency on substrate species.	Guanosine Diphosphate	196-199	uncoupling protein 1	Homo sapiens	51-62
8163011-2	1994	Fatty acid binding site on isolated mitochondrial uncoupling protein (UcP) is demonstrated using EPR spectroscopy of 5-DOXYL-stearic acid (5-SASL), which also activated H+ transport in proteoliposomes containing UcP.	Fatty Acids	0-10	uncoupling protein 1	Homo sapiens	70-73
8163011-2	1994	Fatty acid binding site on isolated mitochondrial uncoupling protein (UcP) is demonstrated using EPR spectroscopy of 5-DOXYL-stearic acid (5-SASL), which also activated H+ transport in proteoliposomes containing UcP.	Fatty Acids	0-10	uncoupling protein 1	Homo sapiens	212-215
8163011-2	1994	Fatty acid binding site on isolated mitochondrial uncoupling protein (UcP) is demonstrated using EPR spectroscopy of 5-DOXYL-stearic acid (5-SASL), which also activated H+ transport in proteoliposomes containing UcP.	5-doxylstearic acid	117-137	uncoupling protein 1	Homo sapiens	70-73
8399375-13	1993	In brown adipose tissue, the special thermogenic organ of mammals, long-chain fatty acids promote operation of the unique natural uncoupling protein, thermogenin.	long-chain fatty acids	67-89	uncoupling protein 1	Homo sapiens	150-161
8468458-7	1993	These results show that an anti-rat UCP antibody can be used for immunohistochemical detection of UCP in human brown adipose tissue and that it provides a useful method for distinguishing between white and brown fat in paraffin-embedded samples.	Paraffin	219-227	uncoupling protein 1	Homo sapiens	36-39
7698343-1	1995	Competition of fatty acids (FA) and alkylsulfonates with 5-DOXYL-stearic acid (5-SASL) binding to isolated mitochondrial uncoupling protein (UcP) is demonstrated using EPR spectroscopy.	Fatty Acids	15-26	uncoupling protein 1	Homo sapiens	141-144
7698343-1	1995	Competition of fatty acids (FA) and alkylsulfonates with 5-DOXYL-stearic acid (5-SASL) binding to isolated mitochondrial uncoupling protein (UcP) is demonstrated using EPR spectroscopy.	Alkanesulfonates	36-51	uncoupling protein 1	Homo sapiens	141-144
7698343-1	1995	Competition of fatty acids (FA) and alkylsulfonates with 5-DOXYL-stearic acid (5-SASL) binding to isolated mitochondrial uncoupling protein (UcP) is demonstrated using EPR spectroscopy.	5-doxylstearic acid	57-77	uncoupling protein 1	Homo sapiens	141-144
7698343-1	1995	Competition of fatty acids (FA) and alkylsulfonates with 5-DOXYL-stearic acid (5-SASL) binding to isolated mitochondrial uncoupling protein (UcP) is demonstrated using EPR spectroscopy.	5-sasl	79-85	uncoupling protein 1	Homo sapiens	141-144
7698343-3	1995	Since alkylsulfonates are UcP substrates, it suggests that the FA binding site is located in the anion channel.	Alkanesulfonates	6-21	uncoupling protein 1	Homo sapiens	26-29
8163011-2	1994	Fatty acid binding site on isolated mitochondrial uncoupling protein (UcP) is demonstrated using EPR spectroscopy of 5-DOXYL-stearic acid (5-SASL), which also activated H+ transport in proteoliposomes containing UcP.	5-doxylstearic acid	117-137	uncoupling protein 1	Homo sapiens	212-215
8163011-2	1994	Fatty acid binding site on isolated mitochondrial uncoupling protein (UcP) is demonstrated using EPR spectroscopy of 5-DOXYL-stearic acid (5-SASL), which also activated H+ transport in proteoliposomes containing UcP.	5-sasl	139-145	uncoupling protein 1	Homo sapiens	70-73
8163011-2	1994	Fatty acid binding site on isolated mitochondrial uncoupling protein (UcP) is demonstrated using EPR spectroscopy of 5-DOXYL-stearic acid (5-SASL), which also activated H+ transport in proteoliposomes containing UcP.	5-sasl	139-145	uncoupling protein 1	Homo sapiens	212-215
7691596-1	1993	The uncoupling protein (UCP) of brown adipose tissue mitochondria is a specialized member of the family of evolutionarily related mitochondrial membrane transporters, which also includes the ADP/ATP translocator and the phosphate carrier.	Adenosine Diphosphate	191-194	uncoupling protein 1	Homo sapiens	24-27
7691596-1	1993	The uncoupling protein (UCP) of brown adipose tissue mitochondria is a specialized member of the family of evolutionarily related mitochondrial membrane transporters, which also includes the ADP/ATP translocator and the phosphate carrier.	Adenosine Triphosphate	195-198	uncoupling protein 1	Homo sapiens	24-27
7691596-1	1993	The uncoupling protein (UCP) of brown adipose tissue mitochondria is a specialized member of the family of evolutionarily related mitochondrial membrane transporters, which also includes the ADP/ATP translocator and the phosphate carrier.	Phosphates	220-229	uncoupling protein 1	Homo sapiens	24-27
1420170-1	1992	The nucleotide binding site of the uncoupling protein (UCP) from brown adipose tissue was mapped by photoaffinity labeling with 2-azidoadenosine 5"-triphosphate (2-azido-ATP) and by affinity labeling with 3"-O-(5-fluoro-2,4-dinitrophenyl)adenosine 5"-triphosphate (FDNP-ATP).	2-azidoadenosine 5'-triphosphate	162-173	uncoupling protein 1	Homo sapiens	55-58
1420170-1	1992	The nucleotide binding site of the uncoupling protein (UCP) from brown adipose tissue was mapped by photoaffinity labeling with 2-azidoadenosine 5"-triphosphate (2-azido-ATP) and by affinity labeling with 3"-O-(5-fluoro-2,4-dinitrophenyl)adenosine 5"-triphosphate (FDNP-ATP).	3"-o-(5-fluoro-2,4-dinitrophenyl)adenosine 5"-triphosphate	205-263	uncoupling protein 1	Homo sapiens	55-58
1420170-1	1992	The nucleotide binding site of the uncoupling protein (UCP) from brown adipose tissue was mapped by photoaffinity labeling with 2-azidoadenosine 5"-triphosphate (2-azido-ATP) and by affinity labeling with 3"-O-(5-fluoro-2,4-dinitrophenyl)adenosine 5"-triphosphate (FDNP-ATP).	fdnp-atp	265-273	uncoupling protein 1	Homo sapiens	55-58
1420170-4	1992	Like the natural ligands ATP and GTP, both analogs are capable of inhibiting the H+/OH- conductance of the UCP as measured in proteoliposomes with reconstituted UCP.	Adenosine Triphosphate	25-28	uncoupling protein 1	Homo sapiens	107-110
1420170-4	1992	Like the natural ligands ATP and GTP, both analogs are capable of inhibiting the H+/OH- conductance of the UCP as measured in proteoliposomes with reconstituted UCP.	Guanosine Triphosphate	33-36	uncoupling protein 1	Homo sapiens	107-110
1420170-4	1992	Like the natural ligands ATP and GTP, both analogs are capable of inhibiting the H+/OH- conductance of the UCP as measured in proteoliposomes with reconstituted UCP.	Guanosine Triphosphate	33-36	uncoupling protein 1	Homo sapiens	161-164
1420170-5	1992	2-azido-ATP was incorporated into UCP in mitochondria in the presence of carboxyatractylate, while FDNP-ATP was inserted into isolated UCP by prolonged incubation at room temperature under pH variation.	2-azidoadenosine 5'-triphosphate	0-11	uncoupling protein 1	Homo sapiens	34-37
1420170-5	1992	2-azido-ATP was incorporated into UCP in mitochondria in the presence of carboxyatractylate, while FDNP-ATP was inserted into isolated UCP by prolonged incubation at room temperature under pH variation.	Adenosine Triphosphate	8-11	uncoupling protein 1	Homo sapiens	34-37
1420170-10	1992	On the basis of published data that no tyrosine participates in nucleotide binding of the UCP, the probable residue reacting with FDNP-ATP is cysteine-253.	Adenosine Triphosphate	135-138	uncoupling protein 1	Homo sapiens	90-93
1420170-10	1992	On the basis of published data that no tyrosine participates in nucleotide binding of the UCP, the probable residue reacting with FDNP-ATP is cysteine-253.	Cysteine	142-150	uncoupling protein 1	Homo sapiens	90-93
34515626-8	2021	In contrast, a high-sucrose diet induced increased number of large-sized lipid droplets, increased CD68+ macrophage- and MCP-1-positive areas, and decreased UCP-1 positive area in the thoracic aortic PVAT (tPVAT).	Sucrose	20-27	uncoupling protein 1	Homo sapiens	157-162
2116978-0	1990	Norepinephrine-induced synthesis of the uncoupling protein thermogenin (UCP) and its mitochondrial targeting in brown adipocytes differentiated in culture.	Norepinephrine	0-14	uncoupling protein 1	Homo sapiens	59-70
2116978-0	1990	Norepinephrine-induced synthesis of the uncoupling protein thermogenin (UCP) and its mitochondrial targeting in brown adipocytes differentiated in culture.	Norepinephrine	0-14	uncoupling protein 1	Homo sapiens	72-75
2116978-3	1990	The synthesis of UCP was stimulated by norepinephrine at physiological concentrations and was observable already after 2 h. It was evident from immunoelectron microscopy that the newly synthesised protein was targeted to the mitochondrial inner membrane, demonstrating the functional competence of these cultured cells.	Norepinephrine	39-53	uncoupling protein 1	Homo sapiens	17-20
33798544-1	2021	Non-shivering thermogenesis in brown adipose tissue is mediated by uncoupling protein 1 (UCP1), which provides a carefully regulated proton re-entry pathway across the mitochondrial inner membrane operating in parallel to the ATP synthase and allowing respiration, and hence thermogenesis, to be released from the constraints of respiratory control.	Adenosine Triphosphate	226-229	uncoupling protein 1	Homo sapiens	67-87
33798544-1	2021	Non-shivering thermogenesis in brown adipose tissue is mediated by uncoupling protein 1 (UCP1), which provides a carefully regulated proton re-entry pathway across the mitochondrial inner membrane operating in parallel to the ATP synthase and allowing respiration, and hence thermogenesis, to be released from the constraints of respiratory control.	Adenosine Triphosphate	226-229	uncoupling protein 1	Homo sapiens	89-93
33798544-2	2021	In the 40 years since UCP1 was first described, an extensive, and frequently contradictory, literature has accumulated, focused on the acute physiological regulation of the protein by fatty acids, purine nucleotides and possible additional factors.	Fatty Acids	184-195	uncoupling protein 1	Homo sapiens	22-26
33798544-2	2021	In the 40 years since UCP1 was first described, an extensive, and frequently contradictory, literature has accumulated, focused on the acute physiological regulation of the protein by fatty acids, purine nucleotides and possible additional factors.	Purine Nucleotides	197-215	uncoupling protein 1	Homo sapiens	22-26
32858880-0	2020	Increased Risk of High Body Fat and Altered Lipid Metabolism Associated to Suboptimal Consumption of Vitamin A Is Modulated by Genetic Variants rs5888 (SCARB1), rs1800629 (UCP1) and rs659366 (UCP2).	Vitamin A	101-110	uncoupling protein 1	Homo sapiens	172-176
1378400-1	1992	An improved procedure for reincorporation of isolated uncoupling protein (UCP) from brown adipose tissue into phospholipid vesicles is reported and H+ uptake in K(+)-driven exchange diffusion quantitatively analyzed.	Phospholipids	110-122	uncoupling protein 1	Homo sapiens	74-77
1378400-2	1992	UCP is isolated and reconstituted with medium-length linear-chain alkyl polyoxyethylene.	alkyl polyoxyethylene	66-87	uncoupling protein 1	Homo sapiens	0-3
1378400-13	1992	The linear correlation of H(+)-transport inhibition to GTP binding demonstrates that all UCP molecules incorporated are equally active.	Guanosine Triphosphate	55-58	uncoupling protein 1	Homo sapiens	89-92
1378400-17	1992	By demonstrating that valinomycin-induced K+ and H+ fluxes reflect relaxation into the diffusion equilibrium state, the transport rate of UCP can be evaluated as a first-order rate, VH+/CH+, in which the rate, VH+, is related to H(+)-uptake capacity, CH+.	Valinomycin	22-33	uncoupling protein 1	Homo sapiens	138-141
1756853-2	1991	Recent studies have revealed that uncoupling by fatty acids in mitochondria is mediated by the ATP/ADP antiporter and, in brown fat, by thermogenin which is structurally very similar to the antiporter.	Fatty Acids	48-59	uncoupling protein 1	Homo sapiens	136-147
1860614-7	1991	UCP gene expression is strongly controlled at the level of transcription by signals that are activated after the stimulation of brown adipocytes by norepinephrine.	Norepinephrine	148-162	uncoupling protein 1	Homo sapiens	0-3
1860614-8	1991	The comparison of UCP gene with the genes encoding the adenine nucleotide translocator revealed the existence of structural and evolutionary homologies.	Adenine Nucleotides	55-73	uncoupling protein 1	Homo sapiens	18-21
2380264-14	1990	The primary structure of UCP is significantly homologous to the primary structure of the human T1 ADP/ATP carrier, particularly in the C-terminal extremity, which is supposed to contain a nucleotide-binding site in both proteins.	Adenosine Diphosphate	98-101	uncoupling protein 1	Homo sapiens	25-28
2380264-14	1990	The primary structure of UCP is significantly homologous to the primary structure of the human T1 ADP/ATP carrier, particularly in the C-terminal extremity, which is supposed to contain a nucleotide-binding site in both proteins.	Adenosine Triphosphate	102-105	uncoupling protein 1	Homo sapiens	25-28
34523169-4	2021	AO exposure significantly increases the expressions of beige-specific genes (Cidea, Cited1, Ppargc1alpha, Prdm16, Tbx1, Tmem26, and Ucp1) and brown-fat signature proteins (UCP1, PRDM16, and PGC-1alpha), and suppresses the expressions of lipogenic marker proteins while enhancing the protein levels of lipolysis in white adipocytes.	Acridine Orange	0-2	uncoupling protein 1	Homo sapiens	132-136
34718051-0	2021	Adipose tissue expression of UCP1 and PRDM16 genes and their association with postprandial triglyceride metabolism and glucose intolerance.	Triglycerides	91-103	uncoupling protein 1	Homo sapiens	29-33
34718051-0	2021	Adipose tissue expression of UCP1 and PRDM16 genes and their association with postprandial triglyceride metabolism and glucose intolerance.	Glucose	119-126	uncoupling protein 1	Homo sapiens	29-33
34718051-2	2021	Therefore, we planned to study the adipose tissue expression of UCP1 and PRDM 16 genes in subjects with glucose intolerance to find out its association with postprandial triglyceride (PPTg) measures and T2DM.	Glucose	104-111	uncoupling protein 1	Homo sapiens	64-68
34718051-8	2021	CONCLUSION: This study found downregulation of PRDM16 and UCP1 gene expression in SAT in subjects with glucose intolerance.	Glucose	103-110	uncoupling protein 1	Homo sapiens	58-62
34833103-4	2021	When EPS was applied, we found that co-culturing led to increases in UCP1 (p = 0.044; d = 1.29) and IL-6 (p = 0.097; d = 1.13) protein expression in the 3T3-L1 adipocytes.	eps	5-8	uncoupling protein 1	Homo sapiens	69-73
34331001-5	2021	RESULTS: The results showed that SVF cells obtained from NW or OIS subjects were able to differentiate into beige adipocytes according to an increased expression of beige biomarkers including UCP1, PDRM-16, PGC1alpha, CIDEA, and SHOX2 upon exposure to genistein.	Genistein	252-261	uncoupling protein 1	Homo sapiens	192-196
34523169-4	2021	AO exposure significantly increases the expressions of beige-specific genes (Cidea, Cited1, Ppargc1alpha, Prdm16, Tbx1, Tmem26, and Ucp1) and brown-fat signature proteins (UCP1, PRDM16, and PGC-1alpha), and suppresses the expressions of lipogenic marker proteins while enhancing the protein levels of lipolysis in white adipocytes.	Acridine Orange	0-2	uncoupling protein 1	Homo sapiens	172-176
34246002-2	2021	This study proposed a novel free RMnS generation method in ultrasound enhanced carbon nanotube (CNTs)/permanganate process (UCP) for organics removal.	Carbon	79-85	uncoupling protein 1	Homo sapiens	124-127
34572374-6	2021	Both db/db mice and humans given pioglitazone displayed increased expression of UCP-1, a marker typically associated with brown adipose tissue.	Pioglitazone	33-45	uncoupling protein 1	Homo sapiens	80-85
34465552-9	2021	RESULTS: Our data demonstrated that baicalin up-regulates the expression of UCP1 and PGC1a in a dose-dependent manner in vitro.	baicalin	36-44	uncoupling protein 1	Homo sapiens	76-80
34465552-10	2021	Baicalin also increases ERK phosphorylation, and the increased expression of UCP1 and PGC1a in adipocytes could be inhibited by an ERK inhibitor, U0126.	baicalin	0-8	uncoupling protein 1	Homo sapiens	77-81
34465552-10	2021	Baicalin also increases ERK phosphorylation, and the increased expression of UCP1 and PGC1a in adipocytes could be inhibited by an ERK inhibitor, U0126.	U 0126	146-151	uncoupling protein 1	Homo sapiens	77-81
34832860-6	2021	Furthermore, both UCP1-dependent proton leak and UCP1-independent, creatine-driven substrate cycle coupled thermogenesis were augmented upon BMP7 addition.	Creatine	67-75	uncoupling protein 1	Homo sapiens	49-53
34721992-0	2021	Betulinic acid decreases lipid accumulation in adipogenesis-induced human mesenchymal stem cells with upregulation of PGC-1alpha and UCP-1 and post-transcriptional downregulation of adiponectin and leptin secretion.	betulinic acid	0-14	uncoupling protein 1	Homo sapiens	133-138
34527816-0	2021	Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytes.	Pyruvaldehyde	0-13	uncoupling protein 1	Homo sapiens	59-79
34527816-0	2021	Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytes.	Isoproterenol	25-38	uncoupling protein 1	Homo sapiens	59-79
34527816-3	2021	Here, we show that MG negatively affects the expression of uncoupling protein 1 (UCP1), which is involved in thermogenesis and the regulation of systemic metabolism.	Pyruvaldehyde	19-21	uncoupling protein 1	Homo sapiens	59-79
34527816-3	2021	Here, we show that MG negatively affects the expression of uncoupling protein 1 (UCP1), which is involved in thermogenesis and the regulation of systemic metabolism.	Pyruvaldehyde	19-21	uncoupling protein 1	Homo sapiens	81-85
34527816-5	2021	We found that MG attenuated the increase in Ucp1 expression following treatment with isoproterenol in beige adipocytes.	Pyruvaldehyde	14-16	uncoupling protein 1	Homo sapiens	44-48
34527816-5	2021	We found that MG attenuated the increase in Ucp1 expression following treatment with isoproterenol in beige adipocytes.	Isoproterenol	85-98	uncoupling protein 1	Homo sapiens	44-48
34527816-6	2021	However, MG did not affect protein kinase A signaling, the core coordinator of isoproterenol-induced Ucp1 expression.	Isoproterenol	79-92	uncoupling protein 1	Homo sapiens	101-105
34527816-8	2021	We found that JNK inhibition, but not p38, recovered isoproterenol-stimulated Ucp1 expression under MG treatment.	Isoproterenol	53-66	uncoupling protein 1	Homo sapiens	78-82
34527816-8	2021	We found that JNK inhibition, but not p38, recovered isoproterenol-stimulated Ucp1 expression under MG treatment.	Pyruvaldehyde	100-102	uncoupling protein 1	Homo sapiens	78-82
34246002-3	2021	Taking ciprofloxacin as a target contaminant, the removal efficiency in the UCP process (9.78 s-1) was remarkably higher than that of the permanganate (0.71 s-1) and CNTs/permanganate (2.57 s-1) processes.	Ciprofloxacin	7-20	uncoupling protein 1	Homo sapiens	76-79
34246002-6	2021	In the UCP process, non-free radical modes including RMnS oxidation (49.8%) and electron transfer (23.5%) were the dominant processes for ciprofloxacin removal in the UCP process, and hydroxyl radical oxidation (13.2%), CNTs adsorption (5.5%), and PM oxidation (8.0%) also contributed to ciprofloxacin removal.	rmns	53-57	uncoupling protein 1	Homo sapiens	7-10
34246002-6	2021	In the UCP process, non-free radical modes including RMnS oxidation (49.8%) and electron transfer (23.5%) were the dominant processes for ciprofloxacin removal in the UCP process, and hydroxyl radical oxidation (13.2%), CNTs adsorption (5.5%), and PM oxidation (8.0%) also contributed to ciprofloxacin removal.	rmns	53-57	uncoupling protein 1	Homo sapiens	167-170
34246002-6	2021	In the UCP process, non-free radical modes including RMnS oxidation (49.8%) and electron transfer (23.5%) were the dominant processes for ciprofloxacin removal in the UCP process, and hydroxyl radical oxidation (13.2%), CNTs adsorption (5.5%), and PM oxidation (8.0%) also contributed to ciprofloxacin removal.	Ciprofloxacin	138-151	uncoupling protein 1	Homo sapiens	7-10
34453052-4	2021	Using a step-wise screening approach, we discover that the organophosphate insecticide chlorpyrifos suppresses UCP1 and mitochondrial respiration in BAT at concentrations as low as 1 pM.	Organophosphates	59-74	uncoupling protein 1	Homo sapiens	111-115
34246002-6	2021	In the UCP process, non-free radical modes including RMnS oxidation (49.8%) and electron transfer (23.5%) were the dominant processes for ciprofloxacin removal in the UCP process, and hydroxyl radical oxidation (13.2%), CNTs adsorption (5.5%), and PM oxidation (8.0%) also contributed to ciprofloxacin removal.	Ciprofloxacin	138-151	uncoupling protein 1	Homo sapiens	167-170
34453052-4	2021	Using a step-wise screening approach, we discover that the organophosphate insecticide chlorpyrifos suppresses UCP1 and mitochondrial respiration in BAT at concentrations as low as 1 pM.	Chlorpyrifos	87-99	uncoupling protein 1	Homo sapiens	111-115
34246002-6	2021	In the UCP process, non-free radical modes including RMnS oxidation (49.8%) and electron transfer (23.5%) were the dominant processes for ciprofloxacin removal in the UCP process, and hydroxyl radical oxidation (13.2%), CNTs adsorption (5.5%), and PM oxidation (8.0%) also contributed to ciprofloxacin removal.	Promethium	248-250	uncoupling protein 1	Homo sapiens	7-10
34246002-6	2021	In the UCP process, non-free radical modes including RMnS oxidation (49.8%) and electron transfer (23.5%) were the dominant processes for ciprofloxacin removal in the UCP process, and hydroxyl radical oxidation (13.2%), CNTs adsorption (5.5%), and PM oxidation (8.0%) also contributed to ciprofloxacin removal.	Ciprofloxacin	288-301	uncoupling protein 1	Homo sapiens	7-10
34246002-7	2021	Interestingly, CNTs could be well reused in the UCP process as more than 88.75% of ciprofloxacin was removed after five times reuse of CNTs.	Ciprofloxacin	83-96	uncoupling protein 1	Homo sapiens	48-51
34246002-8	2021	The UCP process provides a novel strategy for rapid contaminants removal in water treatment via continuous generation of free RMnS.	Water	76-81	uncoupling protein 1	Homo sapiens	4-7
34445344-6	2021	Rapamycin, as an mTOR inhibitor, blocked T3-induced autophagic suppression and UCP1 upregulation.	Sirolimus	0-9	uncoupling protein 1	Homo sapiens	79-83
34439844-0	2021	Mitochondrial Uncoupling Proteins (UCP1-UCP3) and Adenine Nucleotide Translocase (ANT1) Enhance the Protonophoric Action of 2,4-Dinitrophenol in Mitochondria and Planar Bilayer Membranes.	2,4-Dinitrophenol	124-141	uncoupling protein 1	Homo sapiens	35-39
34445344-8	2021	Most of the T3 effects, including mTOR activation, UCP1 upregulation, and OCR increase, were abrogated by intracellular Ca2+ chelation with BAPTA-AM.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	140-148	uncoupling protein 1	Homo sapiens	51-55
34445344-10	2021	Furthermore, edelfosine, a phospholipase C (PLC) inhibitor, prevented T3 from acting on (Ca2+)i, UCP1 abundance, Psim, and OCR.	edelfosine	13-23	uncoupling protein 1	Homo sapiens	97-101
34445344-11	2021	We suggest that short-term exposure of T3 induces UCP1 upregulation and mitochondrial activation due to PLC-mediated (Ca2+)i elevation in brown adipocytes.	Triiodothyronine	39-41	uncoupling protein 1	Homo sapiens	50-54
34384787-5	2021	Further detailed analysis involving chromatin immunoprecipitation and luciferase assays demonstrated that FoxP4 directly controls the levels of UCP1, a key regulator of thermogenesis that uncouples fatty acid oxidation from ATP production.	Fatty Acids	198-208	uncoupling protein 1	Homo sapiens	144-148
34197627-3	2021	cAMP stimulation of differentiated adipocytes led to elevated uptake of serine, cysteine, and glycine, in parallel with increased oxygen consumption, augmented UCP1-dependent proton leak, increased creatine-driven substrate cycle coupled respiration, and upregulation of thermogenesis marker genes and several respiratory complex subunits; these outcomes were impeded in the presence of the specific ASC-1 inhibitor, BMS-466442.	Cyclic AMP	0-4	uncoupling protein 1	Homo sapiens	160-164
34384787-5	2021	Further detailed analysis involving chromatin immunoprecipitation and luciferase assays demonstrated that FoxP4 directly controls the levels of UCP1, a key regulator of thermogenesis that uncouples fatty acid oxidation from ATP production.	Adenosine Triphosphate	224-227	uncoupling protein 1	Homo sapiens	144-148
35504266-8	2022	Results demonstrated that CM treatment improved the angiogenesis of vascularized eWATs (veWATs), and veWATs demonstrated decreased glycerol release but increased Ucp1 expression, compared to eWATs.	Cm	26-28	uncoupling protein 1	Homo sapiens	162-166
35614225-2	2022	IH results from the action of long-chain fatty acids on uncoupling protein 1 (UCP1) in brown fat2-6 and ADP/ATP carrier (AAC) in other tissues1,7-9, but the underlying mechanism is poorly understood.	Fatty Acids	41-52	uncoupling protein 1	Homo sapiens	56-76
35614225-2	2022	IH results from the action of long-chain fatty acids on uncoupling protein 1 (UCP1) in brown fat2-6 and ADP/ATP carrier (AAC) in other tissues1,7-9, but the underlying mechanism is poorly understood.	Fatty Acids	41-52	uncoupling protein 1	Homo sapiens	78-82
35614225-5	2022	Here we report the direct measurement of IH induced by DNP, FCCP and other common protonophores and find that it is dependent on AAC and UCP1.	2,4-Dinitrophenol	55-58	uncoupling protein 1	Homo sapiens	137-141
35614225-5	2022	Here we report the direct measurement of IH induced by DNP, FCCP and other common protonophores and find that it is dependent on AAC and UCP1.	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	60-64	uncoupling protein 1	Homo sapiens	137-141
35541900-10	2022	Impaired activation of mitophagy weakens the regulation effect of UCP1 on metastasis of TNBC, similar to the impairment of GSDME activation on the proliferation regulation of UCP1 on TNBC.	gsdme	123-128	uncoupling protein 1	Homo sapiens	175-179
35612892-0	2022	Berberine chloride (dual topoisomerase I and II inhibitor) modulate mitochondrial uncoupling protein (UCP1) in molecular docking and dynamic with in-vitro cytotoxic and mitochondrial ATP production.	berberine chloride	0-18	uncoupling protein 1	Homo sapiens	102-106
35612892-6	2022	The focus of this study was to determine the role of Berberine on mitochondrial uncoupling protein (UCP1), ATP production, and cytotoxic effect of HEK293T cell at a time and dose-dependent manner analysis by CCK8 assay.	Berberine	53-62	uncoupling protein 1	Homo sapiens	100-104
35612892-8	2022	In this study, berberine chloride significantly up-regulates UCP1 gene expression in brown adipocytes.	berberine chloride	15-33	uncoupling protein 1	Homo sapiens	61-65
35612892-12	2022	The first time, we used molecular docking and dynamic of Berberine with UCP1 gene in this study and revealed therapeutic potential of Berberine via modulation of mitochondrial UCP1 gene.	Berberine	57-66	uncoupling protein 1	Homo sapiens	72-76
35612892-12	2022	The first time, we used molecular docking and dynamic of Berberine with UCP1 gene in this study and revealed therapeutic potential of Berberine via modulation of mitochondrial UCP1 gene.	Berberine	57-66	uncoupling protein 1	Homo sapiens	176-180
35612892-12	2022	The first time, we used molecular docking and dynamic of Berberine with UCP1 gene in this study and revealed therapeutic potential of Berberine via modulation of mitochondrial UCP1 gene.	Berberine	134-143	uncoupling protein 1	Homo sapiens	72-76
35612892-12	2022	The first time, we used molecular docking and dynamic of Berberine with UCP1 gene in this study and revealed therapeutic potential of Berberine via modulation of mitochondrial UCP1 gene.	Berberine	134-143	uncoupling protein 1	Homo sapiens	176-180
35554517-8	2022	Succinate treatment of ASCs elevated the expression of several beige AT markers from controls and from patients with inactive disease, including uncoupling protein-1 (UCP1).	Succinic Acid	0-9	uncoupling protein 1	Homo sapiens	145-165
35554517-8	2022	Succinate treatment of ASCs elevated the expression of several beige AT markers from controls and from patients with inactive disease, including uncoupling protein-1 (UCP1).	Succinic Acid	0-9	uncoupling protein 1	Homo sapiens	167-171
35504660-1	2022	Canonical non-shivering thermogenesis (NST) in brown and beige fat relies on uncoupling protein 1 (UCP1)-mediated heat generation, although alternative mechanisms of NST have been identified, including sarcoplasmic reticulum (SR)-calcium cycling.	Calcium	230-237	uncoupling protein 1	Homo sapiens	99-103
35504660-11	2022	However, UCP1-independent pathways of thermogenesis, such as sarcoplasmic (SR) calcium cycling, have also been identified, but the regulatory mechanisms and functional significance of these pathways remain largely unexplored.	Calcium	79-86	uncoupling protein 1	Homo sapiens	9-13
35459786-4	2022	This study showed that the treatment with Capsaicin, an agonist of transient receptor potential vanilloid 1, directly activated adipocyte browning such as UCP1 expression, mitochondrial biogenesis, energy consumption rates, and glycerol recycling in ciBAs.	Capsaicin	42-51	uncoupling protein 1	Homo sapiens	155-159
35459786-6	2022	Capsaicin also activated UCP1 expression in immortalised human brown adipocytes but inhibited its expression in mesenchymal stem cell-derived adipocytes.	Capsaicin	0-9	uncoupling protein 1	Homo sapiens	25-29
35238380-2	2022	Heat is produced via UCP1-mediated uncoupling between oxidation of energy substrates and ATP synthesis.	Adenosine Triphosphate	89-92	uncoupling protein 1	Homo sapiens	21-25
35462937-13	2022	Notably, BzATP administration at stage 2 exerted a concentration-dependent inhibition on the enhanced expression of PRDM16, PGC-1alpha, and UCP-1 at D4.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	9-14	uncoupling protein 1	Homo sapiens	140-145
35392250-6	2022	UCP1 activity, and consequently DeltaPsi, were perturbed both by GDP, a well-recognized potent inhibitor of UCP1 and by the chemical uncoupler carbonyl cyanide m-chlorophenyl hydrazone (FCCP).	Guanosine Diphosphate	65-68	uncoupling protein 1	Homo sapiens	0-4
35407115-6	2022	In mature mIPA and hADSCs browning markers, including Ucp1, were up-regulated by EEs.	ees	81-84	uncoupling protein 1	Homo sapiens	54-58
35325306-11	2022	Compared with control group, quercetin group had a higher weight retention rate, a higher gene/protein expression of SIRT1, HSP60, UCP1, PPAR-gamma and VEGF-A, and a higher occurrence of peripheral adipose browning.	Quercetin	29-38	uncoupling protein 1	Homo sapiens	131-135
35178098-13	2022	In vitro experiments demonstrated that stigmasterol reduced lipid accumulation and TG levels in HepG2 cells, and the mechanism may have been related to the activation of the PPARgamma-UCP-1 signalling pathway.	Stigmasterol	39-51	uncoupling protein 1	Homo sapiens	184-189
35178098-13	2022	In vitro experiments demonstrated that stigmasterol reduced lipid accumulation and TG levels in HepG2 cells, and the mechanism may have been related to the activation of the PPARgamma-UCP-1 signalling pathway.	Thioguanine	83-85	uncoupling protein 1	Homo sapiens	184-189
35178098-15	2022	The effect of stigmasterol on the PPARgamma-UCP-1 signalling pathway in enhancing lipid metabolism may represent one of the mechanisms of the Renshen and Chaihu herb pair in the treatment of NAFLD.	Stigmasterol	14-26	uncoupling protein 1	Homo sapiens	44-49
35159714-9	2022	NLC-PUNI-KAA treated with maturing adipocytes decreased lipid accumulation and significantly increased the gene expression levels of fatty acid beta-oxidation (PPARgammaC1alpha, UCP-1 and PRDM-16) pathways when compared to free PUNI (5 mug/dL) treatment.	Fatty Acids	133-143	uncoupling protein 1	Homo sapiens	178-183
35327387-6	2022	UCP1 expression correlated only with norepinephrine levels and its metabolite.	Norepinephrine	37-51	uncoupling protein 1	Homo sapiens	0-4
35327387-10	2022	CONCLUSION: We demonstrate signs of UCP1-dependent norepinephrine-induced thermogenesis connected with higher expression of DIO2, PPARGC1A, CEBPB and PRDM16 in retroperitoneal VAT of PPGL and its relations to circulating HDLc and triglycerides levels.	Norepinephrine	51-65	uncoupling protein 1	Homo sapiens	36-40
35327387-10	2022	CONCLUSION: We demonstrate signs of UCP1-dependent norepinephrine-induced thermogenesis connected with higher expression of DIO2, PPARGC1A, CEBPB and PRDM16 in retroperitoneal VAT of PPGL and its relations to circulating HDLc and triglycerides levels.	Triglycerides	230-243	uncoupling protein 1	Homo sapiens	36-40
35204205-5	2022	This is due to compelling evidence that UCP2/3 fulfill other function(s) and the inability to reproduce findings that UCP1-3 use inducible leaks to control reactive oxygen species (ROS) production.	Reactive Oxygen Species	156-179	uncoupling protein 1	Homo sapiens	118-124
35204205-5	2022	This is due to compelling evidence that UCP2/3 fulfill other function(s) and the inability to reproduce findings that UCP1-3 use inducible leaks to control reactive oxygen species (ROS) production.	Reactive Oxygen Species	181-184	uncoupling protein 1	Homo sapiens	118-124
35204205-14	2022	Additionally, some showed that activating UCP1 or 3 can increase mitochondrial ROS production, even though there is still augmented protection from oxidative stress.	Reactive Oxygen Species	79-82	uncoupling protein 1	Homo sapiens	42-46
35091848-4	2022	Our testing showed that UCP1 functions as a proton transporter in the bacterial membrane, increasing its permeability, decrease ATP synthesis at neutral pH and reducing the viability of E. coli in markedly acidic environments.	Adenosine Triphosphate	128-131	uncoupling protein 1	Homo sapiens	24-28
35167092-2	2022	In brown adipocytes, mobilized fatty acids directly activate uncoupling protein 1, provide fuel for heat generation, and ligands of nuclear receptors that expand the thermogenic gene expression program.	Fatty Acids	31-42	uncoupling protein 1	Homo sapiens	61-81
35167100-5	2022	Methods for characterization described here include norepinephrine-induced thermogenic gene expression using qPCR; norepinephrine-induced mitochondrial uncoupling using the Seahorse XFe96 Analyzer, and norepinephrine-induced expression of UCP1 using the RNAscope  Technology.	Norepinephrine	202-216	uncoupling protein 1	Homo sapiens	239-243
35392250-6	2022	UCP1 activity, and consequently DeltaPsi, were perturbed both by GDP, a well-recognized potent inhibitor of UCP1 and by the chemical uncoupler carbonyl cyanide m-chlorophenyl hydrazone (FCCP).	Guanosine Diphosphate	65-68	uncoupling protein 1	Homo sapiens	108-112
35392250-6	2022	UCP1 activity, and consequently DeltaPsi, were perturbed both by GDP, a well-recognized potent inhibitor of UCP1 and by the chemical uncoupler carbonyl cyanide m-chlorophenyl hydrazone (FCCP).	mesoxalonitrile	143-159	uncoupling protein 1	Homo sapiens	0-4
35392250-6	2022	UCP1 activity, and consequently DeltaPsi, were perturbed both by GDP, a well-recognized potent inhibitor of UCP1 and by the chemical uncoupler carbonyl cyanide m-chlorophenyl hydrazone (FCCP).	m-chlorophenyl hydrazone	160-184	uncoupling protein 1	Homo sapiens	0-4
35392250-6	2022	UCP1 activity, and consequently DeltaPsi, were perturbed both by GDP, a well-recognized potent inhibitor of UCP1 and by the chemical uncoupler carbonyl cyanide m-chlorophenyl hydrazone (FCCP).	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	186-190	uncoupling protein 1	Homo sapiens	0-4
35392250-10	2022	We also found that ADP-altered complex II respiration in complex fashion probably involving decreased DeltaPsi due to ATP synthesis, a GDP-like nucleotide inhibition of UCP1, and allosteric enzyme action.	Adenosine Diphosphate	19-22	uncoupling protein 1	Homo sapiens	169-173
35392250-10	2022	We also found that ADP-altered complex II respiration in complex fashion probably involving decreased DeltaPsi due to ATP synthesis, a GDP-like nucleotide inhibition of UCP1, and allosteric enzyme action.	Guanosine Diphosphate	135-138	uncoupling protein 1	Homo sapiens	169-173