PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
29651981-18	2018	At 52 weeks, the mean total ZAN-BPD score was 11.3 [standard deviation (SD) 6.6] among those participants randomised to lamotrigine and 11.5 (SD 7.7) among those participants randomised to placebo (adjusted mean difference 0.1, 95% CI -1.8 to 2.0; p = 0.91).	Lamotrigine	120-131	zonadhesin	Homo sapiens	28-31
16303057-6	2005	Zlg is similar in adhesion domain content to mammalian zonadhesin; however, the domain order is altered.	antabactin	0-3	zonadhesin	Homo sapiens	55-65
22285433-2	2012	We have recently reported that alpha-ZAL and its major metabolite zearalanone (ZAN) are hydroxylated at the aromatic ring by microsomes from human liver in vitro, thereby forming two catechol metabolites each.	Zeranol	31-40	zonadhesin	Homo sapiens	79-82
29549516-12	2018	RESULTS: According to intention-to-treat, latent growth curve analyses, a significant change in total score of ZAN-BPD symptom severity was observed in the memantine group at 20 mg/daily across time, compared with placebo (p = 0.02).	Memantine	156-165	zonadhesin	Homo sapiens	111-114
22285433-2	2012	We have recently reported that alpha-ZAL and its major metabolite zearalanone (ZAN) are hydroxylated at the aromatic ring by microsomes from human liver in vitro, thereby forming two catechol metabolites each.	Zearalanone	66-77	zonadhesin	Homo sapiens	79-82
22285433-2	2012	We have recently reported that alpha-ZAL and its major metabolite zearalanone (ZAN) are hydroxylated at the aromatic ring by microsomes from human liver in vitro, thereby forming two catechol metabolites each.	catechol	183-191	zonadhesin	Homo sapiens	79-82
22285433-3	2012	Thus, the oxidative metabolism of alpha-ZAL and ZAN resembles that of the endogenous steroidal estrogens 17beta-estradiol (E2) and estrone (E1), which also give rise to two catechols each.	Estradiol	105-121	zonadhesin	Homo sapiens	34-51
22285433-3	2012	Thus, the oxidative metabolism of alpha-ZAL and ZAN resembles that of the endogenous steroidal estrogens 17beta-estradiol (E2) and estrone (E1), which also give rise to two catechols each.	Estrone	131-138	zonadhesin	Homo sapiens	34-51
22285433-3	2012	Thus, the oxidative metabolism of alpha-ZAL and ZAN resembles that of the endogenous steroidal estrogens 17beta-estradiol (E2) and estrone (E1), which also give rise to two catechols each.	Catechols	173-182	zonadhesin	Homo sapiens	34-51
22285433-5	2012	Here we report that hepatic microsomes from five species generate catechol metabolites of alpha-ZAL and ZAN, the highest amounts being formed by human liver microsomes, followed by rat, mouse, steer and swine.	catechol	66-74	zonadhesin	Homo sapiens	104-107
22285433-6	2012	The microsomal extracts and the individual catechols of alpha-ZAL, ZAN, E2 and E1 were found to induce oxidative DNA damage, as measured by the formation of 8-oxo-7,8-dihydro-2"-deoxyguanosine in a cell-free system.	Catechols	43-52	zonadhesin	Homo sapiens	67-70
22285433-6	2012	The microsomal extracts and the individual catechols of alpha-ZAL, ZAN, E2 and E1 were found to induce oxidative DNA damage, as measured by the formation of 8-oxo-7,8-dihydro-2"-deoxyguanosine in a cell-free system.	8-ohdg	157-192	zonadhesin	Homo sapiens	67-70
22285433-9	2012	Thus, some catechol metabolites of alpha-ZAL and ZAN are better pro-oxidants and poorer substrates of COMT than the catechols of E2 and E1.	catechol	11-19	zonadhesin	Homo sapiens	35-52
22285433-9	2012	Thus, some catechol metabolites of alpha-ZAL and ZAN are better pro-oxidants and poorer substrates of COMT than the catechols of E2 and E1.	Catechols	116-125	zonadhesin	Homo sapiens	35-52
21535995-7	2011	Only treatment with olanzapine 5-10 mg/d was associated with significantly greater mean change from baseline to endpoint in ZAN-BPD total score relative to placebo (-8.5 vs -6.8, respectively; P = .010; effect size = 0.29; 95% CI, 0.06-0.52).	Olanzapine	20-30	zonadhesin	Homo sapiens	124-127
21535995-8	2011	Response rates (response indicated by >= 50% decrease from baseline in ZAN-BPD total score) were significantly higher for olanzapine 5-10 mg/d (73.6%) versus olanzapine 2.5 mg/d (60.1%; P = .018) and versus placebo (57.8%; P = .006).	Olanzapine	125-135	zonadhesin	Homo sapiens	74-77
19636254-8	2009	Patients in the lamotrigine group had significantly greater reductions in the total Affective Lability Scale scores (P<0.05) and significantly greater reductions in scores on the affective instability item of the ZAN-BPD (P<0.05).	Lamotrigine	16-27	zonadhesin	Homo sapiens	216-219
19636254-9	2009	A secondary finding was that patients in the lamotrigine group had significantly greater reductions in scores on the ZAN-BPD impulsivity item (P = 0.001).	Lamotrigine	45-56	zonadhesin	Homo sapiens	117-120