PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 18395095-1 2008 BACKGROUND & AIMS: Keratins 8 and 18 (K8/K18) are important hepatoprotective proteins. Adenosine Monophosphate 12-15 keratin 18 Mus musculus 45-48 18395095-8 2008 RESULTS: Compared with control animals, CCl(4) led to similar liver fibrosis but increased injury in K18 R89C mice. Cefaclor 40-43 keratin 18 Mus musculus 101-104 18395095-9 2008 In contrast, thioacetamide caused more severe liver injury and fibrosis in K18 R89C as compared with WT and nontransgenic mice and resulted in increased messenger RNA levels of collagen, tissue inhibitor of metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 13. Thioacetamide 13-26 keratin 18 Mus musculus 75-78 18395095-11 2008 CONCLUSIONS: Over expression of K18 R89C predisposes transgenic mice to thioacetamide- but not CCl(4)-induced liver fibrosis. Thioacetamide 72-85 keratin 18 Mus musculus 32-35 17340120-0 2007 Arsenite induced oxidative damage in mouse liver is associated with increased cytokeratin 18 expression. arsenite 0-8 keratin 18 Mus musculus 78-92 17340120-8 2007 Increased expression of CK18 was observed after exposure to SA. sodium arsenite 60-62 keratin 18 Mus musculus 24-28 17340120-9 2007 The addition of NAC impeded the oxidative effects of SA exposure, decreasing the production of thiobarbituric acid-reactive substances and significantly diminishing the up regulation of CK18 mRNA and protein. Acetylcysteine 16-19 keratin 18 Mus musculus 186-190 17340120-11 2007 Mice treated with intragastric single doses of 2.5 and 5 mg/kg of SA showed an increased expression of CK18. sodium arsenite 66-68 keratin 18 Mus musculus 103-107 17340120-12 2007 Results suggest that CK18 expression may be a sensible early biomarker of oxidative stress and damage induced by arsenite in vitro and in vivo. arsenite 113-121 keratin 18 Mus musculus 21-25 14691202-7 2004 Overexpression of alpha-fetoprotein, c-myc, cyclin D1, proliferation-associated protein PAG, and cytokeratin-18 were more dramatic in arsenic-induced HCC than spontaneous tumors. Arsenic 134-141 keratin 18 Mus musculus 97-111 17018877-9 2006 The expression of genes related to liver fibrosis, such as cytokeratin-18, was slightly increased by the high dose of ethanol, but was unchanged in the Maotai group. Ethanol 118-125 keratin 18 Mus musculus 59-73 16368122-5 2006 Arsenic/TPA treatment resulted in increased expression of alpha-fetoprotein, k-ras, c-myc, estrogen receptor-alpha, cyclin D1, cdk2na, plasminogen activator inhibitor-1, cytokeratin-8, cytokeratin-18, glutathione S-transferases and insulin-like growth factor binding proteins in liver and liver tumors from both male and female mice. Arsenic 0-7 keratin 18 Mus musculus 185-199 16368122-5 2006 Arsenic/TPA treatment resulted in increased expression of alpha-fetoprotein, k-ras, c-myc, estrogen receptor-alpha, cyclin D1, cdk2na, plasminogen activator inhibitor-1, cytokeratin-8, cytokeratin-18, glutathione S-transferases and insulin-like growth factor binding proteins in liver and liver tumors from both male and female mice. Tetradecanoylphorbol Acetate 8-11 keratin 18 Mus musculus 185-199 11839569-6 2002 Common bile duct ligation and cholic acid feeding significantly stimulated CK 8 and CK 18 mRNA and protein levels compared to controls, whereas UDCA had no effect. Cholic Acid 30-41 keratin 18 Mus musculus 84-89 12717381-4 2003 Here we tested the potential role of the K18 R89C mutation on Fas- or TNF-mediated apoptotic liver injury by injecting Fas antibody (Ab) or TNF-alpha plus actinomycin D into mice that overexpress wild-type (WT) human K18 (with intact filament network, termed TG2 mice) or into K18 R89C mice (with disrupted filament network). ammonium ferrous sulfate 62-65 keratin 18 Mus musculus 41-44 12717381-5 2003 K18 R89C mice are significantly more susceptible to Fas-mediated liver injury compared with nontransgenic and TG2 mice. ammonium ferrous sulfate 52-55 keratin 18 Mus musculus 0-3 12717381-9 2003 In conclusion, transgenic mouse K18 mutation and its consequent keratin filament disruption predispose hepatocytes to Fas- but not TNF-mediated apoptotic injury. ammonium ferrous sulfate 118-121 keratin 18 Mus musculus 32-35 11839569-8 2002 Our results show that potentially toxic bile acids induce hepatocytic CK 8 and CK 18 expression and phosphorylation whereas nontoxic UDCA has no effect on CKs. Bile Acids and Salts 40-50 keratin 18 Mus musculus 79-84 11809846-5 2002 When type I and II assembly partners were switched to give rise to mismatched polymers (K5-K18; K8-K14), the interfilament interactions, which determine the structural and mechanical properties of keratin polymers, were significantly altered. Polymers 78-86 keratin 18 Mus musculus 91-94 10625605-6 2000 This Alu element is likely responsible for at least part of the protective effects of the sequences flanking the K18. METHYL HYDROGEN (S)-ACETYLPHOSPHONATE 5-8 keratin 18 Mus musculus 113-116 10625605-8 2000 This Alu element is one component of the locus control region associated with the K18 gene. METHYL HYDROGEN (S)-ACETYLPHOSPHONATE 5-8 keratin 18 Mus musculus 82-85 9864372-7 1998 However, exposure of S52A-expressing mice to the hepatotoxins, griseofulvin or microcystin, which are associated with K18 ser52 and other keratin phosphorylation changes, resulted in more dramatic hepatotoxicity as compared with WT K18-expressing mice. Griseofulvin 63-75 keratin 18 Mus musculus 118-121 9864372-7 1998 However, exposure of S52A-expressing mice to the hepatotoxins, griseofulvin or microcystin, which are associated with K18 ser52 and other keratin phosphorylation changes, resulted in more dramatic hepatotoxicity as compared with WT K18-expressing mice. Griseofulvin 63-75 keratin 18 Mus musculus 232-235 9864372-7 1998 However, exposure of S52A-expressing mice to the hepatotoxins, griseofulvin or microcystin, which are associated with K18 ser52 and other keratin phosphorylation changes, resulted in more dramatic hepatotoxicity as compared with WT K18-expressing mice. microcystin 79-90 keratin 18 Mus musculus 118-121 9864372-7 1998 However, exposure of S52A-expressing mice to the hepatotoxins, griseofulvin or microcystin, which are associated with K18 ser52 and other keratin phosphorylation changes, resulted in more dramatic hepatotoxicity as compared with WT K18-expressing mice. microcystin 79-90 keratin 18 Mus musculus 232-235 10206734-0 1998 Bilirubin binding activity of cytokeratin 18 isolated from the porcine liver. Bilirubin 0-9 keratin 18 Mus musculus 30-44 10206734-1 1998 A porcine liver 40 kDa protein designated SBP40 isolated by affinity chromatography with agarose-linked spermine was identified as a porcine cytokeratin 18 on the basis of partial amino acid sequences of peptides derived by lysylendopeptidase digestion and by its reactivity with two commercially available preparations of monoclonal antibody. Sepharose 89-96 keratin 18 Mus musculus 141-155 10206734-1 1998 A porcine liver 40 kDa protein designated SBP40 isolated by affinity chromatography with agarose-linked spermine was identified as a porcine cytokeratin 18 on the basis of partial amino acid sequences of peptides derived by lysylendopeptidase digestion and by its reactivity with two commercially available preparations of monoclonal antibody. Spermine 104-112 keratin 18 Mus musculus 141-155 9657104-4 1998 In vivo 32P-labeled wt mice, subsequently injected with a lethal dose of MC-LR, showed hyperphosphorylation, disassembly, and reorganization of K8/K18, in particular K18, indicating high phosphate turnover on liver keratins in situ. Phosphorus-32 8-11 keratin 18 Mus musculus 147-150 9657104-4 1998 In vivo 32P-labeled wt mice, subsequently injected with a lethal dose of MC-LR, showed hyperphosphorylation, disassembly, and reorganization of K8/K18, in particular K18, indicating high phosphate turnover on liver keratins in situ. Phosphorus-32 8-11 keratin 18 Mus musculus 166-169 9657104-4 1998 In vivo 32P-labeled wt mice, subsequently injected with a lethal dose of MC-LR, showed hyperphosphorylation, disassembly, and reorganization of K8/K18, in particular K18, indicating high phosphate turnover on liver keratins in situ. cyanoginosin LR 73-78 keratin 18 Mus musculus 147-150 9657104-4 1998 In vivo 32P-labeled wt mice, subsequently injected with a lethal dose of MC-LR, showed hyperphosphorylation, disassembly, and reorganization of K8/K18, in particular K18, indicating high phosphate turnover on liver keratins in situ. cyanoginosin LR 73-78 keratin 18 Mus musculus 166-169 9657104-10 1998 Our study shows that K8/K18 filament assembly is regulated in vivo by serine phosphorylation. Serine 70-76 keratin 18 Mus musculus 24-27 7526151-1 1994 The differentiation of both embryonal carcinoma (EC) and embryonic stem (ES) cells can be triggered in culture by exposure to retinoic acid and results in the transcriptional induction of both the endogenous mouse keratin 18 (mK18) intermediate filament gene and an experimentally introduced human keratin 18 (K18) gene as well as a variety of other markers characteristic of extraembryonic endoderm. Tretinoin 126-139 keratin 18 Mus musculus 214-224 8522591-2 1995 To evaluate the function and potential disease association of K18, we examined the effects of mutating a highly conserved arginine (arg89) of K18. Arginine 122-130 keratin 18 Mus musculus 142-145 8522591-3 1995 Expression of K18 arg89-->his/cys and its normal K8 partner in cultured cells resulted in punctate staining as compared with the typical filaments obtained after expression of wild-type K8/18. Histidine 29-32 keratin 18 Mus musculus 14-17 8522591-3 1995 Expression of K18 arg89-->his/cys and its normal K8 partner in cultured cells resulted in punctate staining as compared with the typical filaments obtained after expression of wild-type K8/18. Cysteine 33-36 keratin 18 Mus musculus 14-17 8770877-9 1996 Here we show that mutant K18 expressing transgenic mice are highly susceptible to hepatotoxicity after acute administration of acetaminophen (400 mg/Kg) or chronic ingestion of griseofulvin (1.25% wt/wt of diet). Acetaminophen 127-140 keratin 18 Mus musculus 25-28 8770877-9 1996 Here we show that mutant K18 expressing transgenic mice are highly susceptible to hepatotoxicity after acute administration of acetaminophen (400 mg/Kg) or chronic ingestion of griseofulvin (1.25% wt/wt of diet). Griseofulvin 177-189 keratin 18 Mus musculus 25-28 7536860-7 1995 The response to the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate stimulation of the phosphorylation of CK 8 and CK 18 was also elicited in contrast to control hepatocytes. Tetradecanoylphorbol Acetate 35-72 keratin 18 Mus musculus 120-125 7526151-1 1994 The differentiation of both embryonal carcinoma (EC) and embryonic stem (ES) cells can be triggered in culture by exposure to retinoic acid and results in the transcriptional induction of both the endogenous mouse keratin 18 (mK18) intermediate filament gene and an experimentally introduced human keratin 18 (K18) gene as well as a variety of other markers characteristic of extraembryonic endoderm. Tretinoin 126-139 keratin 18 Mus musculus 226-230 7521318-7 1994 In vivo [32P]orthophosphate incorporation revealed that the shift of isoelectric forms toward more acidic spots was due to hyperphosphorylation of keratin D. Phosphorus-32 9-12 keratin 18 Mus musculus 147-156 7521318-7 1994 In vivo [32P]orthophosphate incorporation revealed that the shift of isoelectric forms toward more acidic spots was due to hyperphosphorylation of keratin D. Phosphates 13-27 keratin 18 Mus musculus 147-156 1283312-0 1992 Differential phosphorylation of CK8 and CK18 by 12-O-tetradecanoyl-phorbol-13-acetate in primary cultures of mouse hepatocytes. Tetradecanoylphorbol Acetate 48-85 keratin 18 Mus musculus 40-44 1283312-3 1992 Treatment of the hepatocytes with 150 nM 12-O-tetradecanoyl-phorbol-13-acetate (TPA) an activator of protein kinase C induced a transient increase in the level of phosphorylation of CK8 but not CK18. Tetradecanoylphorbol Acetate 41-78 keratin 18 Mus musculus 194-198 1283312-3 1992 Treatment of the hepatocytes with 150 nM 12-O-tetradecanoyl-phorbol-13-acetate (TPA) an activator of protein kinase C induced a transient increase in the level of phosphorylation of CK8 but not CK18. Tetradecanoylphorbol Acetate 80-83 keratin 18 Mus musculus 194-198 1581607-4 1992 Among these marker genes, keratin 18, has been shown to contain an AP-1 binding site, TGA(C/G)TCA, which is essential for high level, differentiation dependent expression and which is transactivated by Jun and Fos proteins. Trichloroacetic Acid 94-97 keratin 18 Mus musculus 26-36 35602059-2 2022 Here we infected K18-hACE2 transgenic mice with B.1, B.1.351/Beta, B.1.617.2/Delta and BA.1.1/Omicron isolates and demonstrated heterogeneous infectivity and pathogenesis. Barium 87-89 keratin 18 Mus musculus 17-20 33773662-8 2021 Ck18- and F4/80-positive cells (indicators of hepatocyte recovery) were reestablished and the number of alpha-SMA positive cells was normalized after long-term RESV treatment. Resveratrol 160-164 keratin 18 Mus musculus 0-4 34586649-0 2022 Therapeutic potential of melatonin and melatonergic drugs on K18-hACE2 mice infected with SARS-CoV-2. Melatonin 25-34 keratin 18 Mus musculus 61-64 34538222-8 2021 Importantly, vaccination with peptide 446-480 or with a cyclic version of peptide 446-488 containing a disulfide bridge between cysteines 480 and 488, protected humanized K18-hACE2 mice from a lethal dose of SARS-CoV-2 (62.5 and 75% of protection; P<0.01 and P<0.001, respectively). Cysteine 128-137 keratin 18 Mus musculus 171-174 2409315-2 1985 The antitumor effect of a subeffective dose of K-18 or an equivalent dose of melphalan alone was enhanced by local hyperthermia. Melphalan 77-86 keratin 18 Mus musculus 47-51 2485136-2 1988 After oral administration of 14C-melphalan and 14C-K-18 to ICR mice with subcutaneously transplanted Ehrlich carcinoma, K-18 was detected at the tumor site by autoradiogram after 48 hrs, but melphalan was not. 14c-melphalan 29-42 keratin 18 Mus musculus 120-124 2485136-2 1988 After oral administration of 14C-melphalan and 14C-K-18 to ICR mice with subcutaneously transplanted Ehrlich carcinoma, K-18 was detected at the tumor site by autoradiogram after 48 hrs, but melphalan was not. Melphalan 33-42 keratin 18 Mus musculus 120-124 2409315-4 1985 Local hyperthermia plus K-18 reduced the dose of melphalan required for tumor growth inhibition by melphalan alone. Melphalan 49-58 keratin 18 Mus musculus 24-28 2409315-4 1985 Local hyperthermia plus K-18 reduced the dose of melphalan required for tumor growth inhibition by melphalan alone. Melphalan 99-108 keratin 18 Mus musculus 24-28 32991915-7 2020 Furthermore, chronic exposure to arsenite led to lower H2A ubiquitination (ubH2A); histone H3 acetylation K18 (H3AcK18); and histone H4 acetylations K5, K8, K12, and K16 (H4tetraAck) in haploid spermatids from testicular tissues. arsenite 33-41 keratin 18 Mus musculus 106-109 33791699-2 2021 Here, we applied live bioluminescence imaging (BLI) to monitor the real-time effects of NAb treatment in prophylaxis and therapy of K18-hACE2 mice intranasally infected with SARS-CoV-2-nanoluciferase. nab 88-91 keratin 18 Mus musculus 132-135 32627038-9 2020 In addition, aspirin upregulated the levels of caspase-cleaved cytokeratin 18, increased the proportion of early apoptotic cells, decreased the levels of clusterin and heat shock protein 70 (HSP 70), upregulated the levels of miRNA-137 and inhibited epidermal growth factor receptor (EGFR) activation. Aspirin 13-20 keratin 18 Mus musculus 63-77 33330500-0 2020 Honokiol Inhibits Melanoma Growth by Targeting Keratin 18 in vitro and in vivo. honokiol 0-8 keratin 18 Mus musculus 47-57 33330500-7 2020 Our results showed that honokiol treatment significantly decreased KRT18 protein level and suppressed the tumor growth in melanoma cell-derived xenograft mice models. honokiol 24-32 keratin 18 Mus musculus 67-72 33330500-8 2020 Hence, KRT18 plays an oncogenic role in melanoma and honokiol can be an inhibitor for KRT18. honokiol 53-61 keratin 18 Mus musculus 7-12 33330500-8 2020 Hence, KRT18 plays an oncogenic role in melanoma and honokiol can be an inhibitor for KRT18. honokiol 53-61 keratin 18 Mus musculus 86-91 33195484-8 2020 Conversely, in CaCl2-induced AAA, K4/K9/K27/K36/K79 monomethylation and K9/K18/K56 acetylation were reduced in AAA tissues, whereas K27 di-/tri-methylation and K14 acetylation were upregulated. Calcium Chloride 15-20 keratin 18 Mus musculus 75-78 29895210-4 2018 Both DES and GEN induced three distinct populations of abnormal endometrial epithelial cells: luminal (SIX1+/P63-/CK14-/CK18+), basal (SIX1+/P63+/CK14+/CK18-), and mixed/bipotential (SIX1+/P63-/CK14+/CK18+), which were all established by early adulthood. Diethylstilbestrol 5-8 keratin 18 Mus musculus 120-124 29719117-4 2018 K8 and its partner K18 are the main beta-cell keratins, and knockout of K8 (K8-/- ) in mice causes mislocalization of glucose transporter 2, mitochondrial defects, reduced insulin content and altered systemic glucose/insulin control. Glucose 118-125 keratin 18 Mus musculus 19-22 29719117-4 2018 K8 and its partner K18 are the main beta-cell keratins, and knockout of K8 (K8-/- ) in mice causes mislocalization of glucose transporter 2, mitochondrial defects, reduced insulin content and altered systemic glucose/insulin control. Glucose 209-216 keratin 18 Mus musculus 19-22 29895210-4 2018 Both DES and GEN induced three distinct populations of abnormal endometrial epithelial cells: luminal (SIX1+/P63-/CK14-/CK18+), basal (SIX1+/P63+/CK14+/CK18-), and mixed/bipotential (SIX1+/P63-/CK14+/CK18+), which were all established by early adulthood. Diethylstilbestrol 5-8 keratin 18 Mus musculus 152-156 29895210-4 2018 Both DES and GEN induced three distinct populations of abnormal endometrial epithelial cells: luminal (SIX1+/P63-/CK14-/CK18+), basal (SIX1+/P63+/CK14+/CK18-), and mixed/bipotential (SIX1+/P63-/CK14+/CK18+), which were all established by early adulthood. Diethylstilbestrol 5-8 keratin 18 Mus musculus 152-156 29891447-5 2018 RESULTS: Compared with the control cells, the hepatocytes treated with ATRA showed a concentration-dependent decrease in AFP expression and increase in the expressions of ALB, CK18, TAT and ApoB. Tretinoin 71-75 keratin 18 Mus musculus 176-180 29350066-7 2018 In BBN group, hyperplastic lesions showed significantly more CK14 and significantly less CK18 staining ( P < 0.05 in each case). Butylhydroxybutylnitrosamine 3-6 keratin 18 Mus musculus 89-93 29785143-11 2018 Results: Pacritinib-treated mice had significantly (P<0.01) reduced fibrotic areas in liver compared to vehicle control and significantly (P<0.05) lower levels of CK18. 11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene 9-19 keratin 18 Mus musculus 169-173 25882495-5 2015 Keratin gene sequencing showed that KRT8 in CT26 cells had a 21-nucleotide deletion while K18 in IEC-6 cells had a 9-amino acid in-frame insertion. 9-amino acid 115-127 keratin 18 Mus musculus 90-93 27527870-6 2016 Ethanol caused both apoptotic and necrotic cell death which was demonstrated by the increase in active caspase-3, caspase-8, cleaved PARP, cleaved CK-18 and the secretion of high mobility group protein B1 (HMGB1). Ethanol 0-7 keratin 18 Mus musculus 147-152 26126491-2 2015 We screened a kinase inhibitor library, using A549 cells that are transduced with a lentivirus keratin 18 (K18) construct, to identify compounds that normalize filament disruption due to K18 Arg90Cys mutation at the conserved arginine. Arginine 226-234 keratin 18 Mus musculus 187-190 26126491-4 2015 Furthermore, PKC412 protected cultured A549 cells that express mutant or wild-type K18 and mouse livers of the K18 Arg90Cys-overexpressing transgenic mice from Fas-induced apoptosis. ammonium ferrous sulfate 160-163 keratin 18 Mus musculus 111-114 26434626-0 2015 Analysis of distinct molecular assembly complexes of keratin K8 and K18 by hydrogen-deuterium exchange. Hydrogen 75-83 keratin 18 Mus musculus 68-71 26434626-0 2015 Analysis of distinct molecular assembly complexes of keratin K8 and K18 by hydrogen-deuterium exchange. Deuterium 84-93 keratin 18 Mus musculus 68-71 24930437-10 2015 In HepG2/Hep3B cells, IL-6 treatment but not IL-1beta or TNF-alpha significantly increased K8 and K18 expression and elevated K18 levels were seen after turpentine injection. Turpentine 153-163 keratin 18 Mus musculus 126-129 24930437-12 2015 A K8 > K18 state occurs in ALD and predisposes to MDB formation. mdb 53-56 keratin 18 Mus musculus 10-13 24463813-4 2014 Fas-stimulation of K18-WT mice or isolated hepatocytes caused K18 degradation. ammonium ferrous sulfate 0-3 keratin 18 Mus musculus 19-25 24945595-3 2014 After 72 h of TSA treatment, MUCs acquired epithelial-like features, which were indicated by increased expression of epithelial markers such as Cdh1, Krt18, and Dsp. trichostatin A 14-17 keratin 18 Mus musculus 150-155 25226618-5 2014 Biseugenol-exposure tumors showed acquired epithelial features such as phosphorylation of E-cadherin, cytokeratin-18 and loss mesenchymal signature Snail, but not vimentin regulation. biseugenol 0-10 keratin 18 Mus musculus 102-116 24463813-3 2014 We found that K18-DE mice develop extensive Fas-mediated liver damage compared to wild-type mice overexpressing K18 (K18-WT). ammonium ferrous sulfate 44-47 keratin 18 Mus musculus 14-17 24463813-4 2014 Fas-stimulation of K18-WT mice or isolated hepatocytes caused K18 degradation. ammonium ferrous sulfate 0-3 keratin 18 Mus musculus 19-22 24463813-5 2014 By contrast, K18-DE livers or hepatocytes maintained intact keratins following Fas-stimulation, but showed hypo-phosphorylation at a major stress-kinase-related keratin 8 (K8) phosphorylation site. ammonium ferrous sulfate 79-82 keratin 18 Mus musculus 13-16 23108452-3 2013 The toxic effects of carbon tetrachloride (CCl(4)), 5-fluorouracil (5-FU), and arsanilic acid (Ars) were evaluated by measuring the expressions of Cytokeratin (CK18) and GATA binding protein 4 (GATA-4) and the activities of aspartate transaminase (AST), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP) during the hepatic differentiation process. Carbon Tetrachloride 21-41 keratin 18 Mus musculus 160-164 23828905-4 2013 Honokiol-treated tumors showed increased epithelial signatures such as E-cadherin, cytokeratin-18 and ER stress marker. honokiol 0-8 keratin 18 Mus musculus 83-97 23319235-8 2013 Ethanol-induced apoptosis, assessed by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling-positive nuclei and accumulation of cytokeratin-18 fragments in the liver, was independent of RIP3. Ethanol 0-7 keratin 18 Mus musculus 166-180 23302291-9 2013 delta-Tocotrienol also induced biomarkers of apoptosis such as Bax and activated caspase 3 along with an increase in plasma levels of CK18. tocotrienol, delta 0-17 keratin 18 Mus musculus 134-138 24120911-7 2014 Apoptotic markers DR5, CK8, CK18 RNA were increased in CA- and DDC-fed hs-RxralphaDeltaex4(-/-) mice. 3,5-diethoxycarbonyl-1,4-dihydrocollidine 63-66 keratin 18 Mus musculus 28-32 23405120-5 2013 As other MCs; uterine MCs (UtMCs) uniformly expressed the epithelial markers beta-catenin, ZO-1, E-cadherin, CD54, CD29, and CK18. mcs 22-25 keratin 18 Mus musculus 125-129 23108452-5 2013 In the CCl(4)-treated group, significant decreases (P < 0.05) of the marker expression were observed by more than 300 muM from day 10 in CK18 and by more than 400 muM of CCl(4) from day 22 in GATA-4, respectively. Cefaclor 7-10 keratin 18 Mus musculus 140-144 22449798-5 2012 Mallory-Denk bodies (MDBs) appeared in krt18-/- mice already at an early stage of intoxication in contrast to krt8-/- mice that did not display MDB formation when fed with DDC. mdb 21-24 keratin 18 Mus musculus 39-44 23045527-7 2012 We mapped a highly conserved "hydrophobic patch" ((1413)FLVI(1416)) in the CFTR C-terminus, known to determine plasmalemmal CFTR stability, as the K18-binding site. flvi 56-60 keratin 18 Mus musculus 147-150 22449798-8 2012 Chronically DDC-intoxicated krt18-/- and wt mice showed a similarly increased degree of steatohepatitis with hepatocyte ballooning and MDB formation. 3,5-diethoxycarbonyl-1,4-dihydrocollidine 12-15 keratin 18 Mus musculus 28-33 22449798-8 2012 Chronically DDC-intoxicated krt18-/- and wt mice showed a similarly increased degree of steatohepatitis with hepatocyte ballooning and MDB formation. mdb 135-138 keratin 18 Mus musculus 28-33 22449798-10 2012 krt18-/- mice developed MDBs whereas krt8-/- mice on the same genetic background did not, highlighting the significance of different structural properties of keratins. mdbs 24-28 keratin 18 Mus musculus 0-5 20034473-4 2010 Once immersed in the Lanford medium, EBs began to show typical hepatic features by day 17, including Alb, AFP, TTR, and AAT expression detected by RT-PCR, and ALB, AFP, and CK18 expression detected by immunostaining. lanford medium 21-35 keratin 18 Mus musculus 173-177 21494671-14 2011 Treatment of the K14-Cdx2 mice with 5"-Azacytidine elicited expression of BE-associated genes including Cdx1, Krt18, and Slc26a3/Dra, suggesting the phenotype could be advanced under certain conditions. Azacitidine 36-50 keratin 18 Mus musculus 110-115 20729838-3 2010 K18 undergoes dynamic O-linked N-acetylglucosamine glycosylation at Ser 30, 31 and 49. Acetylglucosamine 31-50 keratin 18 Mus musculus 0-3 20729838-3 2010 K18 undergoes dynamic O-linked N-acetylglucosamine glycosylation at Ser 30, 31 and 49. Serine 68-71 keratin 18 Mus musculus 0-3 20729838-5 2010 K18-Gly(-) mice are more susceptible to liver and pancreatic injury and apoptosis induced by streptozotocin or to liver injury by combined N-acetyl-D-glucosaminidase inhibition and Fas administration. Streptozocin 93-107 keratin 18 Mus musculus 0-3 20729838-5 2010 K18-Gly(-) mice are more susceptible to liver and pancreatic injury and apoptosis induced by streptozotocin or to liver injury by combined N-acetyl-D-glucosaminidase inhibition and Fas administration. ammonium ferrous sulfate 181-184 keratin 18 Mus musculus 0-3 21680703-5 2011 These results may be related to the opposing effects of prepubertal genistein diet on the expression of Rankl and CK5/CK18 ratio (marker of luminal epithelial cell differentiation) in the mammary gland and estrogen receptor (ER-alpha) and progesterone receptor (PgR) protein levels in the mammary tumor: these all were reduced in the WT mice or increased in Brca1(+/-) mice. Genistein 68-77 keratin 18 Mus musculus 118-122 20034473-4 2010 Once immersed in the Lanford medium, EBs began to show typical hepatic features by day 17, including Alb, AFP, TTR, and AAT expression detected by RT-PCR, and ALB, AFP, and CK18 expression detected by immunostaining. ethylbenzene 37-40 keratin 18 Mus musculus 173-177 19783637-0 2009 High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo. Acetaminophen 92-105 keratin 18 Mus musculus 38-48 19796649-3 2010 Furthermore, immunohistochemistry demonstrated profound overexpression of CK8 and CK18 proteins (CK8/18) in all basophilic foci, mixed cell type foci, HCAs and HCCs in B6C3F1 and C57BL/6J mice initiated with DEN. Diethylnitrosamine 208-211 keratin 18 Mus musculus 82-86 19783637-7 2009 The inhibition of APAP-induced apoptosis and K18 cleavage by the caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp(OMe) fluoromethyl ketone are associated with increased hepatic damage, by a shift to necrotic cell death only. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 83-139 keratin 18 Mus musculus 45-48 19205032-10 2009 Ethanol feeding also increased transferase-mediated dUTP-biotin nick-end labeling-positive cells, caspase-3 activity, and cytokeratin-18 staining in the liver. Ethanol 0-7 keratin 18 Mus musculus 122-136 19397691-0 2009 Keratin 18 provides resistance to Fas-mediated liver failure in mice. ammonium ferrous sulfate 34-37 keratin 18 Mus musculus 0-10 18697208-4 2008 MDB formation was compared using hematoxylin-and-eosin staining, or immunofluorescence staining with antibodies to K8/K18/ubiquitin, or biochemically by blotting with antibodies to transglutaminase-2/p62 proteins and to K8/K18/ubiquitin to detect keratin cross-linking. mdb 0-3 keratin 18 Mus musculus 118-121 18697208-4 2008 MDB formation was compared using hematoxylin-and-eosin staining, or immunofluorescence staining with antibodies to K8/K18/ubiquitin, or biochemically by blotting with antibodies to transglutaminase-2/p62 proteins and to K8/K18/ubiquitin to detect keratin cross-linking. mdb 0-3 keratin 18 Mus musculus 223-226 19010845-5 2008 RESULTS: ABT-737-treated tumors regressed by 48 hours (P < 0.01) compared with controls, correlating with increased cleaved cytokeratin 18 (P < 0.01; 6 and 24 hours) and increased intact cytokeratin 18 (P < 0.01; 24 hours). 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid 9-12 keratin 18 Mus musculus 127-141 19010845-5 2008 RESULTS: ABT-737-treated tumors regressed by 48 hours (P < 0.01) compared with controls, correlating with increased cleaved cytokeratin 18 (P < 0.01; 6 and 24 hours) and increased intact cytokeratin 18 (P < 0.01; 24 hours). 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid 9-12 keratin 18 Mus musculus 193-207 19010845-8 2008 CONCLUSIONS: ABT-737 caused tumor regression by apoptosis in H146 xenografts that mapped to a drug-specific, early increase in circulating cleaved cytokeratin 18 that subsequently declined. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid 13-16 keratin 18 Mus musculus 147-161