PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
24844815-1	2014	Cytosolic acetyl-CoA is involved in the synthesis of a variety of compounds, including waxes, sterols and rubber, and is generated by the ATP citrate lyase (ACL).	Acetyl Coenzyme A	10-20	acetone-cyanohydrin lyase	Arabidopsis thaliana	138-155
28532507-4	2017	However, two enzymes acting upstream of HMGR have not been characterized in dandelion latex: ATP citrate lyase (ACL), which provides the acetyl-CoA utilized in the MVA pathway, and acetoacetyl-CoA thiolase (AACT), which catalyzes the first step in the pathway to produce acetoacetyl-CoA.	Acetyl Coenzyme A	137-147	acetone-cyanohydrin lyase	Arabidopsis thaliana	112-115
28532507-7	2017	RESULTS: The spatial and temporal expression profiles of T. brevicorniculatum ACL and AACT revealed their pivotal role in the synthesis of precursors necessary for isoprenoid biosynthesis in latex.	Terpenes	164-174	acetone-cyanohydrin lyase	Arabidopsis thaliana	78-81
28532507-8	2017	The overexpression of A. thaliana ACL and AACT and HMGR in T. brevicorniculatum latex resulted in the accumulation of all three enzymes, increased the corresponding enzymatic activities and ultimately increased sterol levels by ~5-fold and pentacyclic triterpene and cis-1,4-isoprene levels by ~2-fold.	Sterols	211-217	acetone-cyanohydrin lyase	Arabidopsis thaliana	34-37
28532507-8	2017	The overexpression of A. thaliana ACL and AACT and HMGR in T. brevicorniculatum latex resulted in the accumulation of all three enzymes, increased the corresponding enzymatic activities and ultimately increased sterol levels by ~5-fold and pentacyclic triterpene and cis-1,4-isoprene levels by ~2-fold.	Triterpenes	252-262	acetone-cyanohydrin lyase	Arabidopsis thaliana	34-37
28532507-8	2017	The overexpression of A. thaliana ACL and AACT and HMGR in T. brevicorniculatum latex resulted in the accumulation of all three enzymes, increased the corresponding enzymatic activities and ultimately increased sterol levels by ~5-fold and pentacyclic triterpene and cis-1,4-isoprene levels by ~2-fold.	cis-1,4-isoprene	267-283	acetone-cyanohydrin lyase	Arabidopsis thaliana	34-37
30055263-6	2018	We further uncovered that the transfer of [14C]MeNA from the root to leaf was significantly increased in both MES2 knockdown and NaMT1-overexpressing lines, suggesting that both NaMT1 and MES2 fine-tune the long-distance transport of MeNA, which is ultimately utilized for NAD production.	NAD	273-276	acetone-cyanohydrin lyase	Arabidopsis thaliana	110-114
30055263-6	2018	We further uncovered that the transfer of [14C]MeNA from the root to leaf was significantly increased in both MES2 knockdown and NaMT1-overexpressing lines, suggesting that both NaMT1 and MES2 fine-tune the long-distance transport of MeNA, which is ultimately utilized for NAD production.	NAD	273-276	acetone-cyanohydrin lyase	Arabidopsis thaliana	188-192
30055263-7	2018	Abiotic stress (salt, abscisic acid, and mannitol) treatments, which are known to exacerbate NAD degradation, induce the expression of NaMT1 but suppress MES2 expression, suggesting that MeNA may play a role in stress adaption.	Salts	16-20	acetone-cyanohydrin lyase	Arabidopsis thaliana	154-158
30055263-7	2018	Abiotic stress (salt, abscisic acid, and mannitol) treatments, which are known to exacerbate NAD degradation, induce the expression of NaMT1 but suppress MES2 expression, suggesting that MeNA may play a role in stress adaption.	Abscisic Acid	22-35	acetone-cyanohydrin lyase	Arabidopsis thaliana	154-158
30055263-7	2018	Abiotic stress (salt, abscisic acid, and mannitol) treatments, which are known to exacerbate NAD degradation, induce the expression of NaMT1 but suppress MES2 expression, suggesting that MeNA may play a role in stress adaption.	Mannitol	41-49	acetone-cyanohydrin lyase	Arabidopsis thaliana	154-158
24844815-1	2014	Cytosolic acetyl-CoA is involved in the synthesis of a variety of compounds, including waxes, sterols and rubber, and is generated by the ATP citrate lyase (ACL).	Acetyl Coenzyme A	10-20	acetone-cyanohydrin lyase	Arabidopsis thaliana	157-160
24844815-1	2014	Cytosolic acetyl-CoA is involved in the synthesis of a variety of compounds, including waxes, sterols and rubber, and is generated by the ATP citrate lyase (ACL).	Waxes	87-92	acetone-cyanohydrin lyase	Arabidopsis thaliana	138-155
24844815-1	2014	Cytosolic acetyl-CoA is involved in the synthesis of a variety of compounds, including waxes, sterols and rubber, and is generated by the ATP citrate lyase (ACL).	Waxes	87-92	acetone-cyanohydrin lyase	Arabidopsis thaliana	157-160
24844815-2	2014	Plants over-expressing ACL were generated in an effort to understand the contribution of ACL activity to the carbon flux of acetyl-CoA to metabolic pathways occurring in the cytosol.	Carbon	109-115	acetone-cyanohydrin lyase	Arabidopsis thaliana	23-26
24844815-2	2014	Plants over-expressing ACL were generated in an effort to understand the contribution of ACL activity to the carbon flux of acetyl-CoA to metabolic pathways occurring in the cytosol.	Carbon	109-115	acetone-cyanohydrin lyase	Arabidopsis thaliana	89-92
24844815-2	2014	Plants over-expressing ACL were generated in an effort to understand the contribution of ACL activity to the carbon flux of acetyl-CoA to metabolic pathways occurring in the cytosol.	Acetyl Coenzyme A	124-134	acetone-cyanohydrin lyase	Arabidopsis thaliana	23-26
24844815-2	2014	Plants over-expressing ACL were generated in an effort to understand the contribution of ACL activity to the carbon flux of acetyl-CoA to metabolic pathways occurring in the cytosol.	Acetyl Coenzyme A	124-134	acetone-cyanohydrin lyase	Arabidopsis thaliana	89-92
24844815-4	2014	Increasing the ACL activity via the over-expression of the ACLA and ACLB subunits reversed the phenotypes associated with PHB synthesis while maintaining polymer synthesis.	Polymers	154-161	acetone-cyanohydrin lyase	Arabidopsis thaliana	15-18
24844815-6	2014	Over-expression of ACL in Arabidopsis was associated with a 30% increase in wax on stems, while over-expression of a chimeric homomeric ACL in the laticifer of roots of dandelion led to a four- and two-fold increase in rubber and triterpene content, respectively.	Triterpenes	230-240	acetone-cyanohydrin lyase	Arabidopsis thaliana	19-22
24844815-6	2014	Over-expression of ACL in Arabidopsis was associated with a 30% increase in wax on stems, while over-expression of a chimeric homomeric ACL in the laticifer of roots of dandelion led to a four- and two-fold increase in rubber and triterpene content, respectively.	Triterpenes	230-240	acetone-cyanohydrin lyase	Arabidopsis thaliana	136-139
24844815-7	2014	Synthesis of PHB and over-expression of ACL also changed the amount of the cutin monomer octadecadien-1,18-dioic acid, revealing an unsuspected link between cytosolic acetyl-CoA and cutin biosynthesis.	OCTADECA-2,4-DIENEDIOIC ACID	89-117	acetone-cyanohydrin lyase	Arabidopsis thaliana	40-43
24844815-7	2014	Synthesis of PHB and over-expression of ACL also changed the amount of the cutin monomer octadecadien-1,18-dioic acid, revealing an unsuspected link between cytosolic acetyl-CoA and cutin biosynthesis.	Acetyl Coenzyme A	167-177	acetone-cyanohydrin lyase	Arabidopsis thaliana	40-43
24844815-8	2014	Together, these results reveal the complexity of ACL regulation and its central role in influencing the carbon flux to metabolic pathways using cytosolic acetyl-CoA, including wax and polyisoprenoids.	Carbon	104-110	acetone-cyanohydrin lyase	Arabidopsis thaliana	49-52
24844815-8	2014	Together, these results reveal the complexity of ACL regulation and its central role in influencing the carbon flux to metabolic pathways using cytosolic acetyl-CoA, including wax and polyisoprenoids.	Acetyl Coenzyme A	154-164	acetone-cyanohydrin lyase	Arabidopsis thaliana	49-52
12376641-11	2002	Taken together, these results indicate that ACL, encoded by the ACLA and ACLB genes of Arabidopsis, generates cytosolic acetyl-CoA.	Acetyl Coenzyme A	120-130	acetone-cyanohydrin lyase	Arabidopsis thaliana	44-47
16889651-6	2006	The upregulation of two ABA-induced genes (At5g06760, RAB18) and the downregulation of two ABA-repressed genes (AtCLC-A, ACL) are enhanced in the phs1-3 mutant compared with the wild-type.	Abscisic Acid	24-27	acetone-cyanohydrin lyase	Arabidopsis thaliana	121-124
16889651-6	2006	The upregulation of two ABA-induced genes (At5g06760, RAB18) and the downregulation of two ABA-repressed genes (AtCLC-A, ACL) are enhanced in the phs1-3 mutant compared with the wild-type.	Abscisic Acid	91-94	acetone-cyanohydrin lyase	Arabidopsis thaliana	121-124
15608338-0	2005	Reverse genetic characterization of cytosolic acetyl-CoA generation by ATP-citrate lyase in Arabidopsis.	Acetyl Coenzyme A	46-56	acetone-cyanohydrin lyase	Arabidopsis thaliana	71-88
15608338-4	2005	Plants with even moderately reduced ACL activity have a complex, bonsai phenotype, with miniaturized organs, smaller cells, aberrant plastid morphology, reduced cuticular wax deposition, and hyperaccumulation of starch, anthocyanin, and stress-related mRNAs in vegetative tissue.	Starch	212-218	acetone-cyanohydrin lyase	Arabidopsis thaliana	36-39
15608338-4	2005	Plants with even moderately reduced ACL activity have a complex, bonsai phenotype, with miniaturized organs, smaller cells, aberrant plastid morphology, reduced cuticular wax deposition, and hyperaccumulation of starch, anthocyanin, and stress-related mRNAs in vegetative tissue.	Anthocyanins	220-231	acetone-cyanohydrin lyase	Arabidopsis thaliana	36-39
15608338-6	2005	These data indicate that ACL is required for normal growth and development and that no other source of acetyl-CoA can compensate for ACL-derived acetyl-CoA.	Acetyl Coenzyme A	145-155	acetone-cyanohydrin lyase	Arabidopsis thaliana	133-136
15608338-7	2005	Exogenous malonate, which feeds into the carboxylation pathway of acetyl-CoA metabolism, chemically complements the morphological and chemical alterations associated with reduced ACL expression, indicating that the observed metabolic alterations are related to the carboxylation pathway of cytosolic acetyl-CoA metabolism.	malonic acid	10-18	acetone-cyanohydrin lyase	Arabidopsis thaliana	179-182
15608338-8	2005	The observations that limiting the expression of the cytosolic enzyme ACL reduces the accumulation of cytosolic acetyl-CoA-derived metabolites and that these deficiencies can be alleviated by exogenous malonate indicate that ACL is a nonredundant source of cytosolic acetyl-CoA.	Acetyl Coenzyme A	112-122	acetone-cyanohydrin lyase	Arabidopsis thaliana	70-73
15608338-8	2005	The observations that limiting the expression of the cytosolic enzyme ACL reduces the accumulation of cytosolic acetyl-CoA-derived metabolites and that these deficiencies can be alleviated by exogenous malonate indicate that ACL is a nonredundant source of cytosolic acetyl-CoA.	Acetyl Coenzyme A	112-122	acetone-cyanohydrin lyase	Arabidopsis thaliana	225-228
15608338-8	2005	The observations that limiting the expression of the cytosolic enzyme ACL reduces the accumulation of cytosolic acetyl-CoA-derived metabolites and that these deficiencies can be alleviated by exogenous malonate indicate that ACL is a nonredundant source of cytosolic acetyl-CoA.	malonic acid	202-210	acetone-cyanohydrin lyase	Arabidopsis thaliana	70-73
15608338-8	2005	The observations that limiting the expression of the cytosolic enzyme ACL reduces the accumulation of cytosolic acetyl-CoA-derived metabolites and that these deficiencies can be alleviated by exogenous malonate indicate that ACL is a nonredundant source of cytosolic acetyl-CoA.	malonic acid	202-210	acetone-cyanohydrin lyase	Arabidopsis thaliana	225-228
15608338-8	2005	The observations that limiting the expression of the cytosolic enzyme ACL reduces the accumulation of cytosolic acetyl-CoA-derived metabolites and that these deficiencies can be alleviated by exogenous malonate indicate that ACL is a nonredundant source of cytosolic acetyl-CoA.	Acetyl Coenzyme A	267-277	acetone-cyanohydrin lyase	Arabidopsis thaliana	70-73
15608338-8	2005	The observations that limiting the expression of the cytosolic enzyme ACL reduces the accumulation of cytosolic acetyl-CoA-derived metabolites and that these deficiencies can be alleviated by exogenous malonate indicate that ACL is a nonredundant source of cytosolic acetyl-CoA.	Acetyl Coenzyme A	267-277	acetone-cyanohydrin lyase	Arabidopsis thaliana	225-228
11171137-1	2000	ATP citrate lyase (ACL) catalyses the ATP-dependent reaction between citrate and CoA to form oxaloacetate and acetyl-CoA.	Adenosine Triphosphate	0-3	acetone-cyanohydrin lyase	Arabidopsis thaliana	19-22
11171137-1	2000	ATP citrate lyase (ACL) catalyses the ATP-dependent reaction between citrate and CoA to form oxaloacetate and acetyl-CoA.	Citric Acid	4-11	acetone-cyanohydrin lyase	Arabidopsis thaliana	19-22
11171137-1	2000	ATP citrate lyase (ACL) catalyses the ATP-dependent reaction between citrate and CoA to form oxaloacetate and acetyl-CoA.	Oxaloacetic Acid	93-105	acetone-cyanohydrin lyase	Arabidopsis thaliana	0-17
11171137-1	2000	ATP citrate lyase (ACL) catalyses the ATP-dependent reaction between citrate and CoA to form oxaloacetate and acetyl-CoA.	Oxaloacetic Acid	93-105	acetone-cyanohydrin lyase	Arabidopsis thaliana	19-22
11171137-1	2000	ATP citrate lyase (ACL) catalyses the ATP-dependent reaction between citrate and CoA to form oxaloacetate and acetyl-CoA.	Acetyl Coenzyme A	110-120	acetone-cyanohydrin lyase	Arabidopsis thaliana	0-17
11171137-1	2000	ATP citrate lyase (ACL) catalyses the ATP-dependent reaction between citrate and CoA to form oxaloacetate and acetyl-CoA.	Acetyl Coenzyme A	110-120	acetone-cyanohydrin lyase	Arabidopsis thaliana	19-22
11171137-7	2000	Our results indicate that ACL generates the cytosolic pool of acetyl-CoA, which is the substrate required for the biosynthesis of a variety of phytochemicals, including cuticular waxes and flavonoids.	Acetyl Coenzyme A	62-72	acetone-cyanohydrin lyase	Arabidopsis thaliana	26-29
11171137-7	2000	Our results indicate that ACL generates the cytosolic pool of acetyl-CoA, which is the substrate required for the biosynthesis of a variety of phytochemicals, including cuticular waxes and flavonoids.	Waxes	179-184	acetone-cyanohydrin lyase	Arabidopsis thaliana	26-29
11171137-7	2000	Our results indicate that ACL generates the cytosolic pool of acetyl-CoA, which is the substrate required for the biosynthesis of a variety of phytochemicals, including cuticular waxes and flavonoids.	Flavonoids	189-199	acetone-cyanohydrin lyase	Arabidopsis thaliana	26-29